bluuebunny/crossref_metadata_2025 huggingface dataset:
DIW1 encoding a clade I PP2C phosphatase negatively regulates drought tolerance by de‐phosphorylating TaSnRK1.1 in wheat
Authors: Wang Jingyi , Li Chaonan , Li Long , Gao Lifeng , Hu Ge , Zhang Yanfei , Reynolds Matthew P. , Zhang Xueyong , Jia Jizeng , Mao Xinguo , Jing Ruilian
Published: May 2023

Drought seriously impacts wheat production (Triticum aestivum L.), while the exploitation and utilization of genes for drought tolerance are insufficient. Leaf wilting is a direct reflection of drought tolerance in plants. Clade A PP2Cs are abscisic acid (ABA) co‐receptors playing vital roles in the ABA signaling pathway, regulating drought response. However, the roles of other clade PP2Cs in drought tolerance, especially in wheat, remain largely unknown. Here, we identified a gain‐of‐function drought‐induced wilting 1 (DIW1) gene from the wheat Aikang 58 mutant library by map‐based cloning, which encodes a clade I protein phosphatase 2C (TaPP2C158) with enhanced protein phosphatase activity. Phenotypic analysis of overexpression and CRISPR/Cas9 mutant lines demonstrated that DIW1/TaPP2C158 is a negative regulator responsible for drought resistance. We found that TaPP2C158 directly interacts with TaSnRK1.1 and de‐phosphorylates it, thus inactivating the TaSnRK1.1–TaAREB3 pathway. TaPP2C158 protein phosphatase activity is negatively correlated with ABA signaling. Association analysis suggested that C‐terminal variation of TaPP2C158 changing protein phosphatase activity is highly correlated with the canopy temperature, and seedling survival rate under drought stress. Our data suggest that the favorable allele with lower phosphatase activity of TaPP2C158 has been positively selected in Chinese breeding history. This work benefits us in understanding the molecular mechanism of wheat drought tolerance, and provides elite genetic resources and molecular markers for improving wheat drought tolerance.
Sufficient mesh polyhedral intralesional injection for treatment of keloids
Authors: Jiang Liya , Zhuang Jun , Su Xueshang , Zheng Qiaoyuan , Hu Jintian
Published: May 2023

Background

The recurrence of keloids after intralesional injections is significant, and a review of the literature shows an inconsistent range of success rates. In this study, the modified medical proportion and intralesional injection method were intended to enhance the treatment effect.

Methods

Twenty patients completed the study. Regional block anesthesia (lidocaine, ropivacaine) was performed. Triamcinolone acetonide (40 mg/mL), 5‐fluorouracil (25 mg/mL), and ropivacaine (7.5 mg/mL) were configured in a ratio of 2:1:4 and applied on the lesion by reticular injection (horizontal fan‐shaped stratified and vertical shaking pressurized injection). The minimum volume of injection per square centimeter was approximately 3.5 mL. The outcome indicators were the Vancouver Scar Scale (VSS), Visual Analogue Scale (VAS), treatment frequency.

Results

The patients had an 82% ± 7% average reduction in VSS scores and 89% ± 13% and 93% ± 10% reductions in VAS scores of pain and pruritus, respectively, after an average of 2.5 ± 0.7 injections administered within 1 year.

Conclusion

The sufficient mesh polyhedral intralesional injection can achieve excellent results for the treatment of keloid scars.
The pennate diatom Pseudo‐nitzschia multistriata as a model for diatom life cycles, from the laboratory to the sea
Authors: Ferrante Maria Immacolata , Broccoli Andrea , Montresor Marina
Published: May 2023

Phytoplankton dynamics are regulated by external cues, such as light and nutrients, as well as by biotic interactions and endogenous controls linked to life cycle characteristics. The planktonic pennate diatom Pseudo‐nitzschia multistriata, with a heterothallic mating system with two opposite mating types (MTs), represents a model for the study of diatom life cycles. P. multistriata is a toxic species, able to produce the neurotoxin domoic acid. First described in Japan in 1993, it was detected at the long‐term monitoring station MareChiara (Gulf of Naples, Italy) in 1995. Since then, P. multistriata has been reported from several worldwide coastal sites. A large body of knowledge has been produced on its ecology, genetic diversity, and life cycle characteristics. The availability of these data, the ecological relevance of the Pseudo‐nitzschia genus, and its controllable life cycle with a short generation time made it an ideal species to develop a genetic model system for diatoms. To enable functional studies, a 59 Mb genome sequence and several transcriptomic data were produced, and genetic transformation was optimized. These tools allowed the discovery of the first mating‐type determining gene for diatoms. Gene expression studies and metabolomics analyses defined genes and molecules underpinning different phases of the process of sexual reproduction. This model system, developed to explore the genetics of diatom life cycles, offers the opportunity to parallel experimental observations in the laboratory using in situ meta‐omics analyses along space and time, empowering knowledge on the biology and ecology of the genus.
Daytime affect and sleep EEG activity: A data‐driven exploration
Authors: Zhang Jin‐Xiao , ten Brink Maia , Yan Yan , Goldstein‐Piekarski Andrea , Krause Adam J. , Manber Rachel , Kreibig Sylvia , Gross James J.
Published: May 2023

It has long been thought that links between affect and sleep are bidirectional. However, few studies have directly assessed the relationships between: (1) pre‐sleep affect and sleep electroencephalogram (EEG) activity; and (2) sleep EEG activity and post‐sleep affect. This study aims to systematically explore the correlations between pre‐/post‐sleep affect and EEG activity during sleep. In a community sample of adults (n = 51), we measured participants' positive and negative affect in the evening before sleep and in the next morning after sleep. Participants slept at their residence for 1 night of EEG recording. Using Fourier transforms, the EEG power at each channel was estimated during rapid eye movement sleep and non‐rapid eye movement sleep for the full range of sleep EEG frequencies. We first present heatmaps of the raw correlations between pre‐/post‐sleep affect and EEG power during rapid eye movement and non‐rapid eye movement sleep. We then thresholded the raw correlations with a medium effect size |r| ≥ 0.3. Using a cluster‐based permutation test, we identified a significant cluster indicating a negative correlation between pre‐sleep positive affect and EEG power in the alpha frequency range during rapid eye movement sleep. This result suggests that more positive affect during the daytime may be associated with less fragmented rapid eye movement sleep that night. Overall, our exploratory results lay the foundation for confirmatory research on the relationship between daytime affect and sleep EEG activity.
The rate of adaptive molecular evolution in wild and domesticated Saccharomyces cerevisiae populations
Authors: Raas Maximilian W. D. , Dutheil Julien Y.
Published: May 2023

Through its fermentative capacities, Saccharomyces cerevisiae was central in the development of civilisation during the Neolithic period, and the yeast remains of importance in industry and biotechnology, giving rise to bona fide domesticated populations. Here, we conduct a population genomic study of domesticated and wild populations of S. cerevisiae. Using coalescent analyses, we report that the effective population size of yeast populations decreased since the divergence with S. paradoxus. We fitted models of distributions of fitness effects to infer the rate of adaptive () and non‐adaptive () non‐synonymous substitutions in protein‐coding genes. We report an overall limited contribution of positive selection to S. cerevisiae protein evolution, albeit with higher rates of adaptive evolution in wild compared to domesticated populations. Our analyses revealed the signature of background selection and possibly Hill–Robertson interference, as recombination was found to be negatively correlated with and positively correlated with . However, the effect of recombination on was found to be labile, as it is only apparent after removing the impact of codon usage bias on the synonymous site frequency spectrum and disappears if we control for the correlation with , suggesting that it could be an artefact of the decreasing population size. Furthermore, the rate of adaptive non‐synonymous substitutions is significantly correlated with the residue solvent exposure, a relation that cannot be explained by the population's demography. Together, our results provide a detailed characterisation of adaptive mutations in protein‐coding genes across S. cerevisiae populations.
The philosophical way of life as sub‐creation
Authors: Kramer Eli
Published: May 2023

Richard Shusterman's Philosophy and the Art of Writing suggests something vital about the tension between philosophical discourses that cannot capture or be the full meaning of living a life in relation to wisdom, and lived philosophies that cannot do away with discourses to deepen a lived experience beyond them: that philosophy as “an embodied way of life” is a sub‐creation that emerges from the tension between them. This paper uses several different moments and ideas from Philosophy and the Art of Writing as points of departure for further inquiry. Some “memories,” repurposed, reorganized, and manipulated, take up these starting points to further the investigation. The present work was a spiritual exercise for the author and, one hopes, will be for the reader in what it means to practice philosophy as a way of life. By doing so, we may find more forgiveness and appreciation for our philosophical vocation that creates something more than what we say or are now.
Simulated microgravity altered the proliferation, apoptosis, and extracellular matrix formation of L929 fibroblasts and the transforming growth factor‐β1/Smad3 signaling pathway
Authors: Yue Yuan , Yang Jia‐Qi , Lu Sheng‐Yu , Ge Jun , Nie Hong‐Yun , Liu Kai‐Ge , Liu Fei , Li Hao , Yan Hong‐Feng , Zhang Tao , Sun Pei‐Ming , Sun Hong‐Wei , Yang Jian‐Wu , Zhou Jin‐Lian , Cui Yan
Published: May 2023

Exposure to microgravity can adversely affect the fitness of astronauts. The integrity of the skin plays a crucial role in protecting against mechanical forces and infections, fluid imbalance, and thermal dysregulation. In brief, the skin wound may cause unknown challenges to the implementation of space missions. Wound healing is a physiological process that relies on the synergistic action of inflammatory cells, extracellular matrix (ECM), and various growth factors to maintain the integrity of skin after trauma. Fibroblasts are present almost throughout the entire process of wound repair, especially in the scar formation at the endpoint of wound healing. However, there is limited knowledge about the extent to which fibroblasts are affected by the lack of gravity during wound healing. In this study, we utilized the rotary cell culture system, a ground‐based facility that mimics the weightless condition, to study the alterations of L929 fibroblast cells under simulated microgravity (SMG). Our results demonstrated that the SM condition exerted negative influences on the proliferation and ECM formation of the L929 fibroblast. Whereas, the apoptosis of fibroblast was significantly upregulated upon exposure to SMG conditions. Moreover, the transforming growth factor‐β1/Smad3 (TGF‐β1/smad3) signaling pathway of L929 fibroblast related to wound repair was also altered significantly under a weightless environment. Overall, our study provided evidence that fibroblasts are strongly sensitive to SMG and elucidated the potential value of the TGF‐β1/Smad3 signaling pathway modulating wound healing in the future practice of space medicine.
Characterization of the novel KIR3DL3*116 allele identified in a Chinese Han individual
Authors: Yang Zhichao , Chen Hao , Deng Zhihui
Published: May 2023

The novel KIR3DL3*116 allele differs from the closest allele KIR3DL3*00902 by a single missense mutation.
Semantic similarity measure of natural language text through machine learning and a keyword‐aware cross‐encoder‐ranking summarizer—A case study using UCGIS GIS&T body of knowledge
Authors: Tian Yuanyuan , Li Wenwen , Wang Sizhe , Gu Zhining
Published: May 2023

Initiated by the University Consortium of Geographic Information Science (UCGIS), the GIS&T Body of Knowledge (BoK) is a community‐driven endeavor to define, develop, and document geospatial topics related to geographic information science and technologies (GIS&T). In recent years, GIS&T BoK has undergone rigorous development in terms of its topic re‐organization and content updating, resulting in a new digital version of the project. While the BoK topics provide useful materials for researchers and students to learn about GIS, the semantic relationships among the topics, such as semantic similarity, should also be identified so that a better and automated topic navigation can be achieved. Currently, the related topics are either defined manually by editors or authors, which may result in an incomplete assessment of topic relationships. To address this challenge, our research evaluates the effectiveness of multiple natural language processing (NLP) techniques in extracting semantics from text, including both deep neural networks and traditional machine learning approaches. Besides, a novel text summarization—KACERS (Keyword‐Aware Cross‐Encoder‐Ranking Summarizer)—is proposed to generate a semantic summary of scientific publications. By identifying the semantic linkages among key topics, this work guides the future development and content organization of the GIS&T BoK project. It also offers a new perspective on the use of machine learning techniques for analyzing scientific publications and demonstrates the potential of the KACERS summarizer in semantic understanding of long text documents.
THEMIS increases TCR signaling in CD4
+
CD8
+
thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1
Authors: Choi Seeyoung , Lee Jan , Hatzihristidis Teri , Gaud Guillaume , Dutta Avik , Arya Awadhesh , Clubb Lauren M. , Stamos Daniel B. , Markovics Adrienn , Mikecz Katalin , Love Paul E.
Published: May 2023

The T cell lineage–restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. In the SHP1 activation model, THEMIS is proposed to enhance the activity of the tyrosine phosphatase SHP1 (encoded by
Ptpn6
), thereby dampening T cell antigen receptor (TCR) signaling and preventing the inappropriate negative selection of CD4
+
CD8
+
thymocytes by positively selecting ligands. In contrast, in the SHP1 inhibition model, THEMIS is proposed to suppress SHP1 activity, rendering CD4
+
CD8
+
thymocytes more sensitive to TCR signaling initiated by low-affinity ligands to promote positive selection. We sought to resolve the controversy regarding the molecular function of THEMIS. We found that the defect in positive selection in

Themis
−/−

thymocytes was ameliorated by pharmacologic inhibition of SHP1 or by deletion of
Ptpn6
and was exacerbated by SHP1 overexpression. Moreover, overexpression of SHP1 phenocopied the

Themis
−/−

developmental defect, whereas deletion of
Ptpn6
,
Ptpn11
(encoding SHP2), or both did not result in a phenotype resembling that of
Themis
deficiency. Last, we found that thymocyte negative selection was not enhanced but was instead impaired in the absence of THEMIS. Together, these results provide evidence favoring the SHP1 inhibition model, supporting a mechanism whereby THEMIS functions to enhance the sensitivity of CD4
+
CD8
+
thymocytes to TCR signaling, enabling positive selection by low-affinity, self-ligand–TCR interactions.
In lonely mice, astrocytes turn inhibitory
Authors: Ferrarelli Leslie K.
Published: May 2023

Social deprivation in mice switches the role of astrocytes from supporting to inhibiting cognition.
Latent Tuberculosis Infection and Associated Factors in Patients with Systemic Lupus Erythematosus: a Multicenter, Cross-Sectional Study
Authors: Zhang Lifan , Ma Yanan , Jiang Nan , Zou Xiaoqing , Zhang Yueqiu , Zhang Fengchun , Zeng Xiaofeng , Zhao Yan , Liu Shengyun , Zuo Xiaoxia , Wu Huaxiang , Wu Lijun , Li Hongbin , Zhang Zhiyi , Chen Sheng , Zhu Ping , Zhang Miaojia , Qi Wencheng , Liu Yi , Liu Huaxiang , Shi Xiaochun , Liu Xiaoqing
Published: May 2023

The burden of tuberculosis and systemic lupus erythematosus in China ranks among the top three in the world. Therefore, active screening for LTBI and preventive intervention in SLE patients are of great significance in China.
Comprehensive, Comparative Evaluation of 35 Manual SARS-CoV-2 Serological Assays
Authors: Dimech Wayne , Curley Shannon , Subissi Lorenzo , Ströher Ute , Perkins Mark D. , Cunningham Jane
Published: May 2023

The markets have been flooded with hundreds of SARS-CoV-2 serology tests, and although there are many published reports on their performance, comparative reports are far fewer and tend to be limited to only a few tests. In this report, we comparatively assessed 35 rapid diagnostic tests or microtiter plate enzyme immunoassays (EIAs) using a large set of samples from individuals with a history of mild to moderate COVID-19, commensurate with the target population for serosurveillance, which included serum samples from individuals previously infected, at undetermined time periods, with other seasonal human coronaviruses, Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-1.
Design and rationale for the Japanese Registry of Rivaroxaban Effectiveness & Safety for the Prevention of Recurrence in Patients with Deep Vein Thrombosis and Pulmonary Embolism (J’xactly) study
Authors: Okumura Yasuo , Fukuda Ikuo , Nakamura Mashio , Yamada Norikazu , Takayama Morimasa , Maeda Hideaki , Yamashita Takeshi , Ikeda Takanori , Mo Makoto , Yamazaki Tsutomu , Hirayama Atsushi
Published: May 2023

Introduction

Rivaroxaban, a factor Xa inhibitor used as a direct oral anticoagulant, is beneficial over warfarin in terms of food–drug interactions and the need for therapeutic monitoring in patients with acute venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Because there is little data regarding VTE treatment in Japan, a real-world survey of Japanese patients being treated with rivaroxaban for VTE is needed.

Methods and analysis

The Japanese Registry of Rivaroxaban Effectiveness & Safety for the Prevention of Recurrence in Patients with Deep Vein Thrombosis and Pulmonary Embolism has been established to investigate the clinical outcomes of rivaroxaban for the initial treatment and prevention of symptomatic recurrent VTE in Japanese patients with acute symptomatic/asymptomatic VTE. 150 institutions in Japan will enrol patients in the study; the target enrolment is 1000. All patients will be followed up two times a year for at least 18 months and up to 3 years after their enrolment. The primary outcome is symptomatic recurrent VTE occurring during the study period. The principal safety outcome is clinically relevant bleeding (ie, major bleeding or clinically relevant non-major bleeding) occurring during treatment. A clinical events committee will adjudicate all outcomes.

Ethics and dissemination

The study protocol has been approved by the Nihon University Itabashi Hospital, Clinical Research Ethics Committee and all local institutional ethics committees of the participating hospitals. Findings of the study will be presented in scientific sessions and will be published in peer-reviewed journals.

Trial registration number

NCT03091621
Numerical modeling of ice–seabed interaction in layered soil: stiff over soft clay
Authors: Hashemi Seyedhossein , Shiri Hodjat
Published: May 2023

This study presents a numerical investigation of free field ice gouging in layered cohesive seabeds comprising stiff over soft clay. A three-dimensional, half-space, dynamic large deformation finite element analysis was conducted using the Coupled Eulerian Lagrangian approach. To simulate the seabed, a Tresca soil model with the strain rate and strain-softening effects was coded into a user subroutine. The accuracy of the model was verified by comparing its results with those of published experimental studies. Additionally, a comprehensive parametric study was conducted to examine the effect of various ice gouging scenarios and seabed soil parameters on the subgouge soil deformation and the ice keel reaction forces. Our findings revealed that an interactive response occurs between the soil layers and the ice keel that may cause the peak subgouge soil deformation and keel reaction magnitudes to differ from those observed under uniform soil condition. The developed model was found to be an efficient tool for free field ice gouging analysis in cohesive layered seabeds.
On the Shared Transportation Problem: Computational Hardness and Exact Approach
Authors: Davot Tom , Giroudeau Rodolphe , König Jean-Claude
Published: May 2023

In our modern societies, a certain number of people do not own a car, by choice or by obligation. For some trips, there is no or few alternatives to the car. One way to make these trips possible for these people is to be transported by others who have already planned their trips. We propose to model this problem using as path-finding problem in a list edge-colored graph. This problem is a generalization of the [Formula: see text]-path problem, studied by Böhmová et al. We consider two optimization functions: minimizing the number of color changes and minimizing the number of colors. We study for the previous problems, the classic complexity (polynomial-case, NP-completeness, hardness of approximation) and parameter complexity (W[2]-hardness) even in restricted cases. We also propose a lower bound for exact algorithm. On the positive side we provide a polynomial-time approximation algorithm and a FPT algorithm.
Drawing Simultaneously Embedded Graphs with Few Bends
Authors: Grilli Luca , Hong Seok-Hee , Kratochvíl Jan , Rutter Ignaz
Published: May 2023

We study the problem of drawing simultaneously embedded graphs with few bends. We show that for any simultaneous embedding with fixed edges (SEFE) of two graphs, there exists a corresponding drawing realizing this embedding such that common edges are drawn as straight-line segments and each exclusive edge has a constant number of bends. If the common graph is biconnected and induced, a straight-line drawing exists. This yields the first efficient testing algorithm for simultaneous geometric embedding (SGE) for a non-trivial class of graphs.
A MacDowell–Mansouri-type formulation for conformally flat Einstein manifolds
Authors: Rosales-Quintero J. E.
Published: May 2023

We study a pure connection formulation plus algebraic constraints in four spacetime dimensions where the gauge group [Formula: see text]. We show that the action has, as particular cases, the MacDowell–Mansouri and the Stelle–West formulations for gravity. Also, under adequate specification of the constraint terms, we obtain a subset of Einstein manifolds that are torsionless conformally flat manifolds.
Innovation, Economic Growth, and Inequalities: A Panel Dynamic Threshold Analysis for Dynamic Economies
Authors: Khan Sabreen , Pazir Dil
Published: May 2023

This study reinforces the minimal empirical work on the nonlinear relationship between innovative activities, economic growth, and income distribution. Meanwhile, this study assesses panel data of 40 developing economies from 1996 to 2020, wielding the newly developed threshold model by Seo and Shin (2016). Firstly, the empirical findings hold that there exists a nonlinear relationship between the variables. So, by regressing Innovation on economic growth, this study acquires a threshold value of 0.36% of R&D. Hence, indicating above the threshold value of 0.36, the economic growth will revamp. Secondly, regressing R&D on GINI, this study obtains a threshold value of 0.27% of R&D. So, above the threshold value of 0.25, the income inequality will topple down. In contrast, below the threshold level of Innovation will cause both economic growth and income inequality to exacerbate. All in all, the empirical findings of this study suggest that it is plausible to argue that governments and policymakers in developing economies should lavish more on Innovation because higher innovation activities result in inclusive growth.
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner
Authors: Salvi Pooja S. , Shaughnessy Matthew P. , Sumigray Kaelyn D. , Cowles Robert A.
Published: May 2023

Antibiotic-induced microbial depletion of the murine small intestine results in a state of potentiated serotonin activity through reduced epithelial expression of the serotonin transporter. Specifically, serotonin-dependent mechanisms lead to increased intestinal surface area and intestinal stem cell proliferation. Furthermore, the absence of endogenous serotonin leads to blunting of small intestinal villi, suggesting that serotonin signaling is required for epithelial homeostasis.
2EPV‐ApproCom: Enhanced Effective, Private, and Verifiable Approximate Similarity Computation with Server Aided over Scalable Datasets for IoT
Authors: Qiu Shuo , Shi Yanfeng , Liu Yanan , Yan Hao , Zhang Zheng
Published: May 2023

In big data analytics, Jaccard similarity is a widely used block for scalable similarity computation. It is broadly applied in the Internet of Things (IoT) applications, such as credit system, social networking, epidemic tracking, and so on. However, with the increasing privacy concerns of user’s sensitive data for IoT, it is intensively desirable and necessary to investigate privacy‐preserving Jaccard similarity computing over two users’ datasets. To boost the efficiency and enhance the security, we propose two methods to measure Jaccard similarity over private sets of two users under the assistance of an untrusted cloud server in this paper. Concretely, by leveraging an effective Min‐Hash algorithm on encrypted datasets, our protocols output an approximate similarity, which is very close to the exact value, without leaking any additional privacy to the cloud. Our first solution is under a semihonest cloud server, and our enhanced solution introduced the consistency-check mechanism to achieve verifiability in malicious model. For efficiency, the first solution only need about 6 minutes for billion‐element sets. Furthermore, as far as we know, the consistency-check mechanism is proposed for the first time to achieve an effective verifiable approximate similarity computation.
Forest Health Consumption Satisfaction Evaluation with IPA and Factor Analysis
Authors: Liu Bin , Wang Runyu , Lv Jiehua
Published: May 2023

To evaluate the current status of forest health and consumption of the elderly, this work used the questionnaire survey method to collect 587 valid questionnaires about the status of forest health and consumption of the elderly in the capital cities of the three northeastern provinces. This work constructs an importance performance analysis (IPA) quartile and factor analysis satisfaction evaluation system by processing the satisfaction and importance distribution data of the three dimensions of infrastructure, leisure and entertainment, and medical rehabilitation. First, this work extracts four common satisfaction factors based on factor analysis. They are satisfaction of forest characteristic physiotherapy entertainment project, satisfaction of forest rehabilitation basic service project, satisfaction of forest rehabilitation infrastructure construction project, and satisfaction of forest health culture consumption project. Secondly, by calculating the factor scores, it can be found that the forest health consumption satisfaction of the elderly population in the three northeastern provinces is the highest in Shenyang, followed by the Northeast, Harbin is slightly lower than the Northeast, and Changchun is the lowest. At present, the elderly population in the capital cities of the three northeastern provinces is relatively satisfied with the supply of forest sanitation services, and only Shenyang has a driving effect on the comprehensive satisfaction of the capital cities in the three northeastern provinces. It was found that Shenyang’s satisfaction with forest characteristic physiotherapy and entertainment projects and forest health cultural consumption projects and Harbin’s satisfaction with forest reclamation basic service projects and forest reclamation infrastructure construction projects have positive effects on forest reclamation infrastructure construction projects of the three provincial capital cities in Northeast China. However, Changchun City showed opposite effects on the four satisfaction factors. Finally, based on the in-depth analysis of the conclusions, this work puts forward suggestions for the development of the forest health industry and its aging market in the three northeastern provinces.
MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive Pulmonary Disease
Authors: Fang Chun , Kang Baoguo , Zhao Pan , Ran Jing , Wang Lifang , Zhao Lingqiong , Luo Hangyu , Tao Ling
Published: May 2023

The aim of our study was to examine the production of monocyte chemoattractant protein (MCP-4) and eotaxin-3 during the onset and progression of COPD. The expression levels of MCP-4 and eotaxin-3 were evaluated in COPD samples and healthy controls using immunostaining and ELISA. The relationship between the clinic pathological features in the participants and the expression of MCP-4 and eotaxin-3 were evaluated. The association of MCP-4/eotaxin-3 production in COPD patients was also determined. The results revealed enhanced production of MCP-4 and eotaxin-3 in COPD patients especially the cases with AECOPD in both bronchial biopsies and bronchial washing fluid samples. Furthermore, the expression signatures of MCP-4/eotaxin-3 show high AUC values in distinguishing COPD patients and healthy volunteers and AECOPD and stable COPD cases, respectively. Additionally, the number of MCP-4/eotaxin-3 positive cases was notably increased in AECOPD patients compared to those with stable COPD. Moreover, the expression of MCP-4 and eotaxin-3 was positively correlated in COPD and AECOPD cases. In addition, the levels of MCP-4 and eotaxin-3 could be increased in HBEs stimulated with LPS, which is a risk factor of COPD. Moreover, MCP-4 and eotaxin-3 may exert their regulatory functions in COPD by regulating CCR2, 3, and 5. These data indicated that MCP-4 and eotaxin-3 were potential markers for the clinical course of COPD, which could provide guidance for accurate diagnosis and treatment for this disease in future clinical practice.
Pounding Mitigation Design and Real-Time Hybrid Simulation for a Novel Viscous Damper Applied in Bridges
Authors: Ding Yong , Zhang Yifei , Xu Guoshan
Published: May 2023

When the actual displacement of viscous damper exceeds the stroke limit, excessive pounding force may be generated, resulting in damage to the damper. To address this issue, a novel viscous damper with variable stiffness, simple processing, and good economy is proposed. First, the load-displacement relation of the novel viscous damper is established through theoretical analysis and experimental studies. Second, numerical simulations and a series of parametric analyses are conducted to analyze the pounding mitigation effect of the proposed damper. Third, real-time hybrid simulation (RTHS) for considering the pounding effect of the novel viscous damper is presented. Finally, design recommendations for the pounding mitigation design of the novel viscous damper are given. The results show that the novel viscous damper effectively reduces the amplitudes of the pounding force and acceleration by 25% and 24%, respectively. The Fourier power of acceleration decreases in the region from 0.6 Hz to 3.3 Hz. The results of RTHS demonstrate that the real-time hybrid testing system can effectively simulate the pounding effect of the proposed damper. However, the normalized error peak value of velocity between RTHS and the reference result exceeds 10%, indicating that the proposed damper considering the pounding effect imposes new requirements to the real-time hybrid testing method.
Supplemental Table S2 from Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma
Authors: Kelly William , Diaz Duque Adolfo Enrique , Michalek Joel , Konkel Brandon , Caflisch Laura , Chen Yidong , Pathuri Sarath Chand , Madhusudanannair-Kunnuparampil Vinu , Floyd John , Brenner Andrew
Published: May 2023

Exosome (50-120nm N=24) Size and Concentration Analysis
Origen social, competencias lingüísticas y patrones de publicación científica en Argentina, Brasil y Chile
Authors: Almeida Ana Maria , Baranger Denis , Piovani Juan Ignacio
Published: May 2023

En este artículo se analizan las  condiciones de adquisición de  competencia lingüística en lenguainglesa y el uso de idiomas extranjeros en las publicaciones de investigadores de Argentina, Brasil y Chile. El análisis se basa en los resultados de una encuesta cross-national realizada a muestras de investigadores integrados al núcleo central del sistema científico de cada país. En relación con el foco principal del artículo, se abordan las modalidades de adquisición de la competencia lingüística y su relación con factores sociodemográficos, como el origen social, y con la trayectoriaformativa. Por otra parte, se analiza la relación entre las competencias  lingüísticas y la publicación científica, y se explora el lugar de las disciplinas en el uso de idiomas extranjeros. Los  resultados ponen en evidencia que existe una asociación entre el origen social, la trayectoria formativa, lasmodalidades de adquisición de  competencias en inglés y el nivel de dichas competencias. Sin embargo, e independientemente de su dominio de la lengua, la mayoría de los  investigadores de los tres países publica en inglés y, en todo caso, su nivel de competencia tiene incidencia en las estrategias de escritura (autónomas, colaborativas o por traducción profesional). En términoscomparativos, los científicos brasileños son los que más publican en inglés, aunque en el caso chileno la menor proporción de publicaciones en esta lengua podría deberse al mayor peso que tienen en su muestra los  investigadores de ciencias sociales y humanas, toda vez que, en estasdisciplinas, al menos en América Latina, el inglés no ha adquirido un estatus de lingua franca equivalente al de las ciencias naturales.
Duelos e intelectuais no Brasil (1886-1892)
Authors: Severo Marconi
Published: May 2023

Durante os anos finais do Império e o início da República, o duelo foi  vivenciado como uma moda por um pequeno grupo de homens cultos e socialmente bem-colocados. A sua  análise permite apreender as relações estabelecidas entre as classes sociais e o modo como recursos alternativos à esfera estatal, sobretudo no que se refere ao uso da violência privada,  podiam ser mobilizados para resolver pendências pessoais. Embora potencialmente letal, o duelo serviu menos para reparar a honra  supostamente ferida do que como um meio empregado para aumentar e  assegurar a coesão do grupo mediante sua distinção social.
Circulación situada e idiomas de publicación de las élites académicas del Cono Sur
Authors: Beigel Fernanda , Bringel Breno
Published: May 2023

Este artículo analiza la relación entre  las autopercepciones de los  investigadores acerca del valor de la publicación en inglés y la diversidad de prácticas de circulación que se observan en su trayectoria completa de publicaciones. Para ello, nos  basamos metodológicamente en una encuesta trinacional realizada con la élite académica de Argentina, Brasil y Chile y en la observación empírica de una muestra de currículums de investigadores de estos tres países. La contribución del texto apunta en una doble dirección: en términos  conceptuales, proponemos el concepto de “circulación situada” como  alternativa a perspectivas lineales y tradicionales de la internacionalización; en el terreno empírico, mostramos  cómo la bibliodiversidad en las  trayectorias académicas y la multi-escalaridad de la circulación de esos académicos  proyecta una mirada  compleja en los tres casos. Como consecuencia, los hallazgos nos  permiten ir más allá de las visiones habituales sobre el inglés como idioma de publicación y avanzar en el debate sobre el dinamismo del proceso de circulación y sus anclajes socio-institucionales.
Jovens ciganos no ensino médio em Portugal: fatores-chave para a continuidade e o sucesso escolar
Authors: Mendes Maria Manuela , Magano Olga , Pinheiro Sara , Mourão Susana
Published: May 2023

Apesar de em Portugal existirem políticas públicas de combate às desigualdades, incluindo as escolares, a origem socioeconômica, o gênero e a pertença étnica dos estudantes  continuam a ter um impacto incontornável nos percursos escolares. Os ciganos são dos mais afetados por essas desigualdades, reveladas pelas ainda salientes taxas de abandono escolar precoce e por retenções e insucesso escolar. Tendo por base os resultados derivados de entrevistas semidiretivas, o objetivo do artigo consiste em compreender os fatores-chave determinantes nas trajetórias de continuidade escolar dos ciganos no ensino médio. Os resultados revelam jovens tendencialmente mais escolarizados que as gerações anteriores, evidenciando-se a importância do contexto familiar, mas também a agencialidade e a resiliência.
Mobilidade e cidade: epistemologia e pesquisa
Authors: Souza Candice Vidal e
Published: May 2023

O artigo explora a mobilidade,  tratando das características  epistemológicas e das implicações metodológicas de algumas novidades que o chamado mobilities turn tem trazido para a pesquisa social, notadamente para a investigação de processos urbanos. Reflete-se sobre a dimensão inovadora dos estudos atuais em mobilidades, os quais se expandem para além da sociologia e da antropologia e se situam sobretudo na geografia. Em seguida, é  considerada a definição do social e de espaço-tempo epistemologicamente compatível como a virada da mobilidade. Por fim, as consequências dessas posições para a pesquisa em cidades são exploradas para se  concluir que elementos da tradição de pesquisas urbanas convergem para esta cena do presente, revelando afinidades epistemológicas e  conceituais com modos contemporâneos de pensar a cidade.
O retorno do recalcado: Estado e universo literário
Authors: Stella Marcello Giovanni Pocai
Published: May 2023

Resenha de Pomoción cultural y tradución: Férias Internacionales del libro e invitados de honor, Peter Lang, Berna, 2021, de M. Maria Carmen Villarino Pardo et al.
Lei do desmanche, PCC e mercados
Authors: Feltran Gabriel , Rocha Rafael , Maldonado Janaina , Zambon Gregório , Gobbi Fernanda de
Published: May 2023

No estado de São Paulo, as  notificações de roubos e furtos de veículos cresceram entre 2003 e 2014. Desde então, esse tipo de crime tem diminuído. O que explicaria essa  oscilação? Combinando experiências etnográficas e dados quantitativos, o artigo propõe um quadro analítico composto por três hipóteses  explicativas: (i) a implementação da “Lei do Desmanche”; (ii) as  transformações nas dinâmicas do Primeiro Comando da Capital e (iii) as mudanças econômicas associadas à indústria automobilística. Nossos  resultados sugerem que a  implementação da “Lei do Desmanche”, regulando o mercado  ilegal de autopeças, teve efeitos decisivos na diminuição da subtração veicular. As demais hipóteses sugerem efeitos acessórios que também  merecem atenção.
From the scrapyard to the ELV center: when the old car becomes a global resource
Authors: Jacquot Sébastien , Morelle Marie
Published: May 2023

This article focuses on the structuring  of the end-of-life vehicle processing and recycling (ELV processing) sector in France. First, it traces the emergence  and the structuring of scrapyards. It then analyses the gradual introduction of regulations aimed at curbing informality in the sector, and at promoting the development of a  circular economy. Scrapyards, which have now become “ELV recycling centers”, are gradually absorbed into a capitalist and highly technical  apparatus, in the name of a “green economy”. The article proposes to  discuss the value of end-of-life  vehicles, which are often considered as a source of pollution and waste, but  can also be a source of parts and materials, at the intersection of  national and transnational formal and informal circulations.
Formações de Estado, políticas de circulação e infraestrutura crítica: uma entrevista com Finn Stepputat
Authors: Pinho Isabela , Maldonado Janaina , Mano Apoena
Published: May 2023

Entrevista com Finn Stepputat, que ocupa, desde 2003, a posição de Pesquisador Senior no Instituto Dinamarquês de Estudos Internacionais.
Validation of Chronocancer camilosantanai† Santana, Tavares, Martins, Melo & Pinheiro (Crustacea, Decapoda, Brachyura) from the Romualdo Formation, Araripe Sedimentary Basin, Brazil
Authors: Santana William Ricardo Amâncio , Tavares Marcos Domingos Siqueira , Martins Carlos Antônio Muniz , Melo José Patrício Pereira , Pinheiro Allysson Pontes
Published: May 2023

Santana et al. (2022) described a new genus and species of fossil crab, Chronocancer camilosantanai, from carbonate concretions of the Romualdo Formation of the Araripe Sedimentary Basin. The journal in which the description appeared was published online only and the new name did not include a ZooBank registration number (LSID), as required for validation of new names in electronic-only publications. The present note serves to validate the name Chronocancer camilosantanai by fulfilling the ICZN conditions for nomenclatural availability. The date and authorship of the specific name, accordingly, are those of this note, not Santana et al. (2022).
Não há desvio sobre o vazio: a produção do espaço pela desvalorização, atualização e transformação de elementos existentes
Authors: Castro Laura Fonseca de
Published: May 2023

O artigo propõe o desvio (détournement) situacionista como método para a produção de espaço na cidade contemporânea. O desvio usurpa ou copia elementos existentes sem fazer referência a seus proprietários, desvalorizando, atualizando e transformando sua materialidade em um conjunto novo e crítico. Manifestações do desvio em diferentes mídias são analisadas cronologicamente para organizar o processo de formação do conceito, desde as práticas do cinema do Letrismo, das metagrafias e textos da Internacional Letrista e das artes plásticas da Bauhaus Imaginista até sua sistematização como método no “Manual do desvio”, aplicado no cotidiano da Internacional Situacionista. Percebemos o espaço arquitetônico e urbano como suporte a ser desviado, que pode ter suas intenções de projeto e significados históricos subvertidos em ações coletivas.
Notas para uma história do urbanismo labiríntico
Authors: Perniola Mario , Lopes Ana Carolina Fróes Ribeiro , Andrade Carlos Roberto Monteiro de
Published: May 2023

O artigo discute a estrutura labiríntica enquanto expressão da relação dialética existente entre a cidade e os modos de vida das sociedades. Os argumentos são pautados na análise de três diferentes conceitos de labirinto: o místico-religioso, o iluminista e o “unitário”. Enquanto os dois primeiros conceitos ligam-se à interpretação classicista de labirinto, presentes na passagem do cotidiano medieval para o cotidiano burguês, relacionando aspectos de uniformidade, homogeneidade, simetria, ordem e disciplina, o “unitário” liga-se às condições orgânicas e qualitativas da vida natural, na ausência de qualquer divisão funcional do espaço, e num modo de vida baseado na livre expressão dos sentidos humanos.
Bright Lights, Big City. Luces de Gamonal y derecho a la ciudad
Authors: Rojo José Manuel
Published: May 2023

Analiza el fenómeno de reestructuración autoritaria y mercantil del espacio urbano y a la desaparición de los lugares públicos y de los intercambios directos entre los individuos que ocupan estos espacios. Fenómeno mundial que encuentra resistencias e intensas luchas locales donde la revuelta ha recuperado su pulso, revitalizando luchas y formas de luchar e inventando otras nuevas, con la asamblea y el diálogo libre como eje fundamental, la solidaridad y la espontaneidad. El caso de la revuelta del barrio burgalés de Gamonal, ubicado en la ciudad de Burgos en España, es uno de los ejemplos cuidadosamente tratado entre muchas revueltas urbanas alrededor del mundo.
Política habitacional em cidades médias paulistas: entre o social e o mercado
Authors: Damasceno Bárbara Caetano , Goulart Jefferson Oliveira
Published: May 2023

Resumo: A política habitacional dominante no período 2000-2020 registra esvaziamento das ações das esferas estaduais e municipais de governo, com protagonismo do Programa Minha Casa Minha Vida. O PMCMV destinou expressivo volume de recursos à habitação social, mas seu formato institucional inclui notável influência dos agentes privados. A política habitacional em quatro cidades médias do interior paulista revela uma transição que se consumou no paradoxo entre redução da oferta de habitação social e crescente produção mercadológica. Com volume inédito de produção e um discurso vago do direito à moradia, intensifica-se a financeirização da política habitacional em escala nacional. Tal modelo reduziu a política habitacional à produção de moradias e reforçou profundas desigualdades socioespaciais nas formas de expansão urbana dessas cidades.
Corpo, veridicção e testemunho em Memórias do Cárcere, de Graciliano Ramos
Authors: Oliveira Gustavo Maciel de
Published: May 2023

No presente artigo, trataremos de uma questão referente à dimensão veridictória dos discursos, ainda a ser mais explorada em semiótica, a nosso ver: a imbricação (neutralização?) entre regimes subjetivos e objetivos de veridicção presente no discurso autobiográfico. Nossa discussão se dará a partir da obra Memórias do Cárcere (1953), de Graciliano Ramos, que traz inúmeras questões sobre o seu estatuto de “realidade”. Esse desiderato se dará em diálogo com autores como Jacques Fontanille, mormente em sua obra Corpo e sentido; Izidoro Blikstein, e sua noção de verdade subjetiva; e Wander Melo Miranda, em seu trabalho Corpos escritos, dedicado à temática na obra de Graciliano Ramos em estudo. O intento deste artigo é o de mostrar que a peculiaridade veridictória do texto do escritor alagoano é afirmada não pela via de uma enunciação objetivante (mais da ordem do “registro”, da adequação aos fatos), mas pela dimensão estética de sua obra, pela imbricação entre o memorial e o literário e pela força figurativa do sensível e da estesia. Esses elementos nos poriam em face de uma narração mais do devir de um sofrimento, do simulacro de quem “sentiu na pele” a dor, do que de um relato documental dos acontecimentos vividos na cadeia.
Sobre a natureza da narrativa cinematográfica
Authors: Lotman Iúri
Published: May 2023

O ensaio Sobre a natureza da narrativa cinematográfica, de 1993, é um dos últimos trabalhos de Iúri Lotman que concentra suas reflexões sobre a arte cinematográfica, tema ao qual ainda em 1973 o semioticista havia dedicado o livro A semiótica do cinema e os problemas da estética cinematográfica (na tradução lusitana, Estética e semiótica do cinema). Segundo Lotman, a arte cinematográfica imita a estrutura de uma língua natural e, portanto, é uma arte essencialmente narrativa que elabora sua própria linguagem (cinelinguagem). Dentro de uma obra cinematográfica, vista como um texto, é possível destacar frases, tempos verbais e até mesmo rimas e anáforas. Lotman aponta ainda a dualidade complexa do enredo cinematográfico, composto por duas camadas: a “literária” – recontável em palavras e que, em certo sentido, coincide com o roteiro – e a camada puramente cinematográfica, que pode ser imaginada visualmente, mas não pode ser re-expressa em palavras.