bluuebunny/crossref_metadata_2025 huggingface dataset:
Permanencias en los discursos frente a prácticas de cuidado de sí en salud en el género masculino
Authors: González Montes Luz Andrea
Published: November 2022

Objetivo: Comprender los significados sobre el cuidado de sí en salud de un grupo de hombres pertenecientes al mismo tronco familiar en tres generaciones diferentes en la ciudad de Manizales, desde un análisis intergeneracional. Materiales y métodos: Estudio cualitativo, método biográfico desde una perspectiva intergeneracional con historias de vida temáticas, realizado entre 2015 y 2016. Unidad de trabajo: Tres hombres de diferentes generaciones (hijo, padre, abuelo). Unidad de análisis: los discursos producidos en torno al cuidado de sí en salud. Resultados: Los significados sobre el cuidado de sí en salud se construyen a partir de las experiencias de vida de los sujetos en el entramado sociocultural en el cual están inmersos. En el análisis de discursos en las tres generaciones surgieron tres ejes nodales alrededor de las prácticas de conservación u omisión de cuidado de la salud: los discursos que permanecieron; los que presentaron cambios y por último los que se encontraron en tensión. En este artículo se analizan los discursos que permanecieron en las tres generaciones estudiadas alrededor del objeto del estudio. Conclusiones: El estudio permitió evidenciar como a lo largo de los diferentes momentos históricos prevalecen significados y comportamientos que tienen su arraigo en la cultura y que permean en gran medida los estilos de vida adoptados por este grupo de hombres.
Antecedentes de adherencia a tratamiento en pacientes hipertensos de un centro de salud chileno
Authors: Mena Díaz Fernanda Carolina , Nazar Gabriela , Mendoza Parra Sara
Published: November 2022

Objetivo: Esta investigación se propuso analizar el rol predictor de variables sociodemográficas, antecedentes de salud, autoeficacia y estrés en la adherencia al tratamiento de pacientes con hipertensión arterial de un centro de salud de atención primaria chileno. Materiales y Método: Estudio de abordaje cuantitativo de tipo correlacional realizado desde marzo a agosto del 2017. La muestra estuvo constituida por 141 pacientes hipertensos, seleccionada de forma aleatoria e intencionada. Se crearon instrumentos para recoger información sociodemográfica y antecedentes de salud, y se utilizaron las escalas Cuestionario de Conductas de Salud de Miller, SEMCD-S del Stanford Patient Education Research Center y subescala de estrés del DASS-21 de Lovibond y Lovibond para medir adherencia, autoeficacia y estrés respectivamente. Para el análisis de datos se utilizaron medidas de tendencia central y dispersión, comparación entre grupos, análisis de correlación y regresión lineal múltiple con apoyo de los programas SPSS versión 21 y R. Resultados: La adherencia total se relacionó de manera débil pero significativa con autoeficacia (r=,224) y de manera negativa con estrés (r=-,170*). La edad, el no consumo de cigarrillos y el conocimiento de que la enfermedad es una condición crónica resultaron ser predictoras de adherencia al tratamiento. Conclusión: Los resultados refuerzan la importancia de variables personales como predictoras de conductas de salud y el rol de la información y educación en la adherencia al tratamiento de personas con hipertensión. Se exploran las implicancias prácticas de estos hallazgos para el funcionamiento del programa cardiovascular.
Profitability of cabbage production by smallholder farmers in the Eastern Cape Province, South Africa
Authors: Mdoda L. , Obi A. , Mzuyanda C. , Jiba P.
Published: November 2022

Cabbage is one of the most cultivated vegetable crops that are used as a staple crop because of its affordability and nutritional value. Improving profit efficiency in vegetable farming is important for both economic, livelihood, and to certain extent - food security. The crop plays a significant role in reducing the poverty levels of the previously disadvantaged in different parts of South Africa.  We argue that cabbage is mostly grown by smallholder farmers whose technical efficiency is not well known. It is for this reason that we take measures towards developing empirical evidence on technical efficiency to enhance its production and advancement. The study estimated technical efficiency and factors of technical inefficiency among smallholder irrigation producers of cabbage. A total of 150 growers were selected from a list of vegetable farmers from Eastern Cape Municipalities using a multi-stage sampling. A stochastic production frontier model was employed while correcting for heteroscedasticity in stochastic and inefficiency error terms. Gross margin was used to determine the profitability of smallholder cabbage farming. The study findings revealed that farming is practiced by the elderly who mainly had primary education. There were increasing returns from cabbage farming and farmer average technical efficiency of about 78%. This implies 21.16% inefficiency level, indicating that there are reserves available to raise revenues through refining practical and allocative competencies of farmers. Farm size (Area), seed and capital were production-increasing variables while fertilizer and labour used were reducing farm returns of cabbage production. Sources of farmer technical inefficiency were age, farm experience, years spent in school, access to extension services, household size and transportation to markets. The provision of formal skills development training and resources for farmers could improve the technical and managerial capacities of farmers.
Nexus between the invisibility of agricultural extension services and rural livelihoods development: Assertions from rural farming communities
Authors: Qwabe Q.N. , Swanepoel J.W. , Van Niekerk J.A. , Zwane E.L.
Published: November 2022

Agricultural extension is one of the essential services that are offered by the South African Department of Agriculture, Land Reform, and Rural Development (DALRRD), to facilitate agricultural development in rural communities. The significance of agricultural extension is that it offers new knowledge to farmers and allows space for growth through various interventions such as agrarian transformation and improving livelihoods through the promotion of agriculture as a vehicle for ‘pro-poor’ economic growth. However, there is a concern that extension services are invisible in resource-restricted and previously marginalised rural communities. The study presented in this paper examined farmer’s experiences with extension practitioners and the impact of a lack of extension services on the development of impoverished rural communities. The researchers adopted a qualitative design wherein six focus group discussions were held to gather data from the farmers. Data were analyzed using ATLAS.ti22, a computer-assisted qualitative data analysis software (CAQDAS). Four themes of extension services that have a direct linkage to livelihood development, namely, the impact on rural livelihoods, production challenges, marketability, and economic impact, and the invisibility of extension services, were the central point of discussion.
Contralateral Cortical Subarachnoid Hemorrhage as a Manifestation of Hyperperfusion Syndrome after Carotid Artery Stenting
Authors: Kim Seung Min , Kang SangJoon , Shin Dong-Hyeon , Ahn Sung-Ho
Published: November 2022

Cerebral hyperperfusion syndrome is a rare but serious complication of carotid revascularization, and characterized by ipsilateral headache, hypertension, seizures, and focal neurological deficits. Therefore, treatment strategies are directed towards regulation of blood pressure and limitation of rises in cerebral perfusion to prevent cerebral edema or hemorrhage, especially during several days after carotid endarterctomy or stenting. We report the unique case of a patient who suffered from contralateral cortical subarachnoid hemorrhage after carotid artery stenting, despite of well-controlled blood pressure.
Posterior Reversible Encephalopathy Syndrome in a Patient with Intoxication of Arisaema amurense
Authors: Kim Hong Jun , Ko Jihee , Kim Minju , Kang Chul-Hoo , Kang Ji-Hoon , Kang Sa-Yoon , Kim Joong-Goo
Published: November 2022

Arisaema amurense is well-known as a poisonous plant. Its toxicity is probably due to calcium oxalate crystal, which provokes the painful oropharyngeal edema, hypersalivation, aphonia, oral ulceration, airway obstruction and hypocalcemia. Posterior reversible encephalopathy syndrome (PRES) is a disorder manifesting as neurological symptoms such as headache, encephalopathy, seizures and visual disturbance with reversible cerebral edema usually involving the bilateral posterior portion of the cerebral hemispheres. Here we report a case of PRES following ingestion of Arisaema amurense.
Rereading Oral Communication Skills in English Language Acquisition: The Unspoken Spoken English
Authors: Robert R. , Meenakshi S.
Published: November 2022

Globalization has had a profound effect on all aspects of society. These extraordinary vicissitudes befall those who have a strong desire to achieve something in their lives. One of the vicissitudes which the current society faces in this globalised world is enhancement in English communication skills. When people clearly convey their thoughts and opinions to others, they achieve their intended objectives of the goal. Since English is a lingua franca of the world, English communication skills are essential at the present time, and mastery of these skills is necessary to succeed in one's chosen field. It is also very evident that, in a globalised world, speaking is the most important of the four language skills. Language classroom is a great setting for learning effective communication skills, especially speaking skills. To help English language learners (ELLs) speak more fluently, teachers must be aware of their challenges and use a variety of teaching strategies, so that ELLs may considerably improve their speaking skills. This paper emphasises the value of learning the foundations of the English-speaking skills. It also explains the role played by several strategies and instructional materials in imparting English speaking skills for EFL/ESL students. Finally, this research offers some useful suggestions for teachers on how to incorporate a variety of activities that encourage ELLs to improve their oral communication skills in English classes.
Regional peculiarities of disability due to uterine cancer
Authors: Idrisova Lilya S. , Suleymanov Elkhan A. , Shurgaya Marina A. , Puzin Sergey N.
Published: November 2022

BACKGROUND: The federal project Fight against oncological diseases for 20182024 has been launched in Russia within the framework of the national project Healthcare. There is significant regional variability in the level and severity of malignant neoplasms (MN), which determines the relevance of studying and monitoring the characteristics of health disorders due to MN in the regions. Disability, as the most important indicator of population health, makes the judgment of the effectiveness of treatment, rehabilitation, and preventive measures possible.
AIMS: To analyze the dynamics and structure of the disability of the female population due to uterine cancer in the Chechen Republic
MATERIALS AND METHODS: Units of observation included newly recognized disabled (NRD) and repeated recognized disabled (RRD) due to uterine cancer during the year. The object of the study included a combination of NRD and RRD due to uterine cancer in the Chechen Republic. The analysis was conducted by three age groups of the adult population (young, middle, and old). This epidemiological, retrospective, and evaluative study was conducted from 2014 to 2020 using documentary, data copying, statistical, and graphical research methods.
RESULTS: The age structure of disability due to uterine cancer revealed 218 (65.5%) elderly, 87 (26.1%) middle-aged, and 28 (8.4%) young females with disabilities. The dynamics by 2020 established that the contingent of young people with disabilities has not significantly changed, with decreased middle-aged and increased elderly females (p=0.0070). The third and second group of disabilities was more often established during the repeated (66.1%) and new (45.6%) examinations, respectively. Concurrently, the proportion of disabled people who were assigned to the first disability group was higher in the RRD cohort. Persistent dysfunctions of the blood system and immune system (100%) in disabled people were accompanied by various types of capacity limitations, with the predominance first degree of their severity. Moreover, a violation of the ability to work of the second degree was diagnosed with a large proportion in the young age segment of the disabled.
CONCLUSION: Within the framework of the project Fight against oncological diseases for 20182024, considering the regional features of the dynamics and structure of the disability of the female population is necessary due to uterine cancer in the Chechen Republic. The presented results of epidemiological and clinical-expert diagnostics should be used in the development of priority areas of anticancer medical and social activities for the prevention of disability (primary and secondary) due to oncogynecological diseases at the regional healthcare level.
Large earthquake occurrence affected by small stress changes
Authors: Rydelek Paul A. , Sacks I. Selwyn
Published: November 2022

Many observations suggest that relatively small changes in stress may trigger or inhibit earthquakes. This result is surprising because the perturbing stress is only a small fraction of the stress drop from the affected earthquake. We investigate this phenomenon by simulating the earthquake fault with a numerical model that is physically realistic. A fault is not homogeneous, and therefore, the failure criteria will vary over the surface of the fault. We model fault heterogeneity as simple Coulomb failure on smaller but mostly uniform areas that comprise the fault. As a result of multiple (and repeated) failures over these small areas, the fault can have a very uneven stored stress. We show that it is possible for small changes in confining stress of a few tenths of a bar to advance or retard the occurrence of large earthquakes by decades. Because such stress changes can be generated by nearby earthquakes, and over much longer time scales by postseismic strain diffusion from large distant earthquakes, estimates of the probabilities of earthquake occurrence must take into account these stress perturbations in order to be reliable.
Formulation, Cure Kinetics, and Performance of Vinyl Ester Photolithography Resins for Digital Light Processing
Authors:   , McLaughlin Jaclyn Alexandra , Magenau Andrew J. D. , Palmese Giuseppe Raffaello
Published: November 2022

The expansion of additive manufacturing (AM) technology is currently limited by the poor performance characteristics of existing materials. Available photocurable acrylate-based resins often to do achieve sufficient properties required for engineering materials or end-use products. Moreover, the proprietary formulations of these systems are not conducive to systematic study. Photocurable vinyl ester (VE) resins containing various reactive diluents (RDs) are investigated in this work to address these challenges. five resins are renowned for their low viscosity, rapid rates of cure, and high thermomechanical performance characteristics. It was found that the processability, printability, copolymerization kinetics, thermal properties, and mechanical performance of printed five thermosets were highly reliant on the type of RD that was used. DMA experiments revealed the Tg of these systems remained well over 100 °C. Additionally, room temperature storage and flexural moduli were measured to be above 2 GPa for all printed materials, which are desirable characteristics for high performance thermosets. Based on the results of these experiments, para-methyl styrene was determined to be the most effective RD for future consideration in five photolithography resin systems.
The Great Equalizer
Authors:   , Wrye Taylor P. , Kiosoglous Cameron
Published: November 2022

This exploratory case study aimed to understand how the sudden and abrupt transition to distance education due to the SARS-CoV-2 pandemic of 2020 highlighted the vast differences in levels of readiness for adopting distance education among the public-school districts throughout the State of Connecticut. It explores the reasons behind the inequities in the implementation of distance learning in public school districts. To develop a more detailed understanding of the problem, the research employs the exploratory approach to identify the contributing factors that render some districts more successful than others in their rollout of distance learning for their students. The experiences of school and district administrators as well their familiarity with advanced learning technologies are utilized. The basis of this study's conceptual framework consists of three streams: the history of public education delivery, perception and familiarity with modern learning, and modern learning and delivery modalities. The guiding research questions are as follows: 1. What defines distance learning in Connecticut public schools? 2. What factors contributed to the adaptation of distance learning from an administrative perspective? 3. What is the current perception of distance learning from critical stakeholders?
Metodología para el análisis estratégico cuantitativo en proyectos a partir del análisis de riesgos
Authors: Salgado Delio , Awad Gabriel
Published: November 2022

Este artículo propone una metodología para la construcción de una matriz de análisis de debilidades, oportunidades, fortalezas y amenazas en la formulación y evaluación de proyectos, con base en estudios cuantitativos de riesgo. Se parte de una revisión de literatura para obtener una descripción del análisis de debilidades, oportunidades, fortalezas y amenazas y sus usos, así como las herramientas en los estudios de riesgos de los proyectos. Luego se muestra un marco metodológico para la construcción de análisis de debilidades, oportunidades, fortalezas y amenazas cuantitativos y los apartados necesarios para llevar a cabo el análisis, el cual se valida con un caso de aplicación. Se concluye que, mediante análisis cuantitativos de riesgos en los proyectos, se puede reducir la subjetividad en la construcción de la matriz estratégica de debilidades, oportunidades, fortalezas y amenazas.
Governance and performance model for agricultural cooperatives
Authors: Silva Fabiana Ferreira da , Baggio Daniel Knebel , Santos David Ferreira Lopes
Published: November 2022

The main goal of this article is to offer a performance model based on the principles and practices of corporate governance applied to agricultural cooperatives. The research uses a quantitative approach based on a survey of agricultural cooperatives established in Brazil. The procedures focused on the descriptive analysis of empirical results, the use factor, and discriminant analysis. Factor analysis reported two dimensions of governance (reliability and transparency) and three of performance (financial control, profitability, and sustainability). The discriminant analysis allowed us to distinguish cooperatives with the best governance practices and those with the best performance. This study presents a performance model based on structured governance principles and practices.
Thermo-economic feasibility analysis of trilateral-cycle power generators for waste heat recovery-to-power applications
Authors: AJIMOTOKAN Habeeb A. , AYUBA Isiaka , IBRAHIM Hassan K.
Published: November 2022

The trilateral cycle (TLC), a promising alternative waste heat recovery-to-power cycle, is receiving increasing attention due to feats such as the high thermal match between the exergy of the heat source temperature profiles and its working fluid. Although the TLC has neither been broadly applied nor commercialised because of its thermo-economic feasibility considerations. This study examined the thermo-economic analysis of different TLC power generator configurations; i.e., the saturated subcritical simple (non-recuperative) and recuperative cycles using n-pentane as the working fluid for low-grade waste heat recovery-to-power generation. Based on the thermodynamic and economic analyses, the feasibility analysis models of the cycles were established using Aspen Plus, considering efficiency, cost, and expected operating and capacity factors. Furthermore, the capacity factor, specific investment cost (SIC), and payback period (PBP), among other, were used to evaluate the cycle design configurations and sizes. The SICs of the simple and recuperative TLCs were 3,683.88 $/kW and 4,220.41 $/kW, and their PBPs were 8.43 years and 8.55 years, respectively. The simple TLC had a lower investment ratio of 0.24 compared to an investment ratio of 0.28 for the recuperative TLC. These economic values suggest that the simple TLC is more cost-effective when compared with the recuperative TLC because the recuperation process does not recompense the associated cost, making it unattractive.
Desafíos geopolíticos y nuevos dilemas para las políticas industriales
Authors: Stezano Federico , Casalet Mónica
Published: November 2022

Este trabajo se inserta en la temática de los nuevos procesos técnicos y productivos a la luz de distintas estrategias nacionales para impulsar su crecimiento en la manufactura y la sociedad. En este marco, el objetivo del trabajo es discutir las posibilidades de las nuevas políticas públicas de desarrollo de nuevas tecnologías digitales en la actual coyuntura global. Subrayando las posibilidades de posicionamiento de Latinoamérica desde una transformación digital basada en el desarrollo y formación de capacidades y talentos.
Para alcanzar dicho objetivo, el trabajo sintetiza los desafíos socioeconómicos que impone el fenómeno de la creciente digitalización, sus beneficios y obstáculos y las respuestas adoptadas por distintos países industrializados y emergentes para promover el avance de las tecnologías digitales y su incorporación tecno productiva y social. En segundo término, el trabajo revisa los hechos críticos de coyuntura actual que determinan opciones de rumbos de transformación digital a nivel global: los escenarios pospandemia, los reposicionamientos geopolíticos influidos por la invasión de Rusia a Ucrania y las estrategias de los países industrializados en busca del liderazgo tecnológico global.
El trabajo concluye que la situación actual de crisis e incertidumbre económica y política impiden prever los caminos futuros de incorporación de nuevas tecnologías digitales. En la búsqueda por el liderazgo tecnológico global, los países industrializados adoptan nuevas tecnologías avanzadas (no sólo las digitales), alentando a los sectores privados a asumir riesgos crecientes de asimilación de esas tecnologías y avanzan en nuevos esquemas institucionales y de regulación. En este escenario, el desafío de los países latinoamericanos reside en localizar nichos tecnológicos donde insertarse desde el apoyo a la formación de talentos y capacidades en la economía y la sociedad para dinamizar la adopción de las nuevas tecnologías desde la acción coordinada de los distintos grupos de la sociedad, las empresas y el Estado.
On the material shock-wave acceleration in a system of plates with the decreasing acoustic hardness
Authors: Fedorov S.V. , Starshikova A.S. , Lyushnin S.A.
Published: November 2022

To obtain the high-speed metal particles in simulating the impact of meteoroids and fragments of space debris on the spacecraft protective screens, shock-wave acceleration of thin metal plates is used at their collision with the impact element accelerated by a light-gas ballistic installation. Such an element is provided at the front end with an insert of layers with acoustic stiffness decreasing outwards. The effect of increasing speed of a plate accelerated by the plate impact is considered, when an intermediate system of plates with monotonically decreasing acoustic impedance is installed between it and the impact element, which values are between the impact element and the accelerated plate impedances. Based on numerical simulation in the framework of a plane one-dimensional problem of continuum mechanics, the shock-wave acceleration of an aluminum plate was studied in its direct collision with a tantalum impact element, as well as in the presence of one intermediate plate of copper or two intermediate plates of copper and titanium between them. An increase in the coefficient of accelerated plate raising speed relative to the impact element speed was registered with an increase in the number of intermediate plates. Using acoustic approximation, an analytical solution to the problem of plate acceleration in the presence of a system of the infinite number of infinitely thin plates with the continuously decreasing acoustic impedance between it and the impact element was obtained.
Experience in creating the oil production tubing with thermal insulation based on basalt and glass fibers
Authors: Komkov M.A. , Tarasov V.A.
Published: November 2022

The paper presents results of design, development, manufacturing technologies, and experimental studies of prototypes of the multilayer tubing with thermal insulation from short basalt fibers and an outer shell of wound glass fiber. New multilayer tube was designed with hardening of the composite outer layer in the section exposed to hydraulic tongs impact during installation and tubes’ lowering into the oil wells. It was demonstrated that high-temperature and low-density thermal insulation of the tubes could be provided with the short basalt superthin fibers by grinding and cleaning them from impurities using the liquid method. Thermal and strength tests of the tube samples with the shortened regular part were made on the certified equipment and showed permissible temperature on the coating outer surface with more than twice higher safety margin of the fiberglass shell regarding tension and torsion.
DEVELOPMENT OF MICROCAPSULES BASED ON COMBINED ANTIDIABETIC SUBSTANCE: PHARMACOLOGICAL CHARACTERISTICS
Authors: Giyoszoda A. , Stepanova E. F. , Veselova O. F. , Storozhenko S. E.
Published: November 2022

The comparative assessment results of the hypoglycemic activity of a combined preparation containing microcapsules with a phytocomposition consisting of Glycyrrhiza glabra L. extracts, a dry extract of Galega officinalis L., Mentha piperita L., and gliclazide, are discussed in the article. Methods for obtaining microcapsules with an original PEG-6000 shell are described.

The aim of the study was to develop an optimal technology for obtaining microcapsules with a PEG-6000 shell containing a combined antidiabetic substance, and conduct its detailed pharmacological study on the model of type 2 diabetes mellitus, to conduct a detailed comparative pharmacological study of a microencapsulated antidiabetic composition with a shell based on PEG-6000, including gliclazide and a sum of phytoextracts on the model of type 2 diabetes mellitus.

Materials and methods. As the main objects of the study, microcapsules with a PEG-6000 shell were obtained using methyl miristate as the base liquid. The capsules contained the amount of plant extracts in their composition: a dry extract of Glycyrrhiza glabra L., a dry extract of Galega officinalis L., a dry extract of Mentha piperita L., and gliclazide. The study of a hypoglycemic activity was carried out after a single administration of drugs to the animals with alloxan-induced type 2 diabetes mellitus. The cumulative effect assessment of the drugs was carried out within 14 days with a test for the resistance to oral glucose on days 7 and 14.

Results. Microcapsules with the original shell were obtained by dispersion in a liquid-liquid system with the adjustment of some technological stages. The effect of the drugs under study on the glycemic profile in the rats with an experimental model of type 2 diabetes mellitus was investigated. A comparative evaluation of the pharmacological effect was carried out with a separate and combined use of microencapsulated preparations.

Conclusion. The rationality of combining phytocomponents and a synthetic antidiabetic agent in microcapsules has been proven. The obtained results testify to the rationality of plant extracts combination and a synthetic hypoglycemic agent – gliclazide in microcapsules.
ADAPTATION OF “DRIED BLOOD DROP” METHOD FOR THERAPEUTIC DRUG MONITORING
Authors: Petrov V. I. , Anikeev I. S. , Zayachnikova T. E. , Strygin A. V. , Dotsenko A. M.
Published: November 2022

To control the concentration of drugs with a narrow therapeutic range, and to conduct effective and safe treatments, Therapeutic Drug Monitoring (TDM) is carried out. However, to date, the implementation of TDM is associated with various difficulties, for the solution of which more convenient and less invasive methods for collecting biological material are being developed.

The aim of the study was to develop protocols for the collection and storage of “dried blood spot” (DBS) samples, as well as protocols for the validation methods for the quantitative determination of drugs in whole blood, using this technology for subsequent therapeutic drug monitoring.

Materials and methods. To analyze a “dried blood spot” method in detail and to identify the characteristic features of taking and storing biosamples, a collection and analysis of scientific literature over the past 10 years has been conducted. The search for literature materials has been carried out from open and accessible sources located in the scientific libraries of institutions, in electronic databases and search engines: Elibrary, PubMed, Scopus, Cyberleninka, Medline, ScienceDirect, Web of Science, Google Scholar. Primary protocols for taking, storing and analyzing samples of the “dried blood drop” have been prepared. To obtain the adequate quality samples, the developed protocols have been tested and optimized at the stages of selection and storage. By high-performance liquid chromatography with mass spectrometric detection (HPLC-MS/MS), using a “dried blood drop” as a sample preparation, drug validation protocols have been optimized to ensure that acceptable validation characteristics were achieved, and subsequent Therapeutic Drug Monitoring was performed.

Results. The features of the collection, storage and analysis of the “dried blood spot” samples have been revealed. Such characteristics as a spot volume effect, a hematocrit effect, a droplet uniformity, which can affect the results of a quantitative HPLC-MS/MS analysis, have been determined. For a successful use of the new methods, appropriate protocols for taking samples of “dried blood spot” from the finger of adult patients and from the heel of newborns, as well as protocols for validating methods for the quantitative determination of drugs from these samples, have been developed.

Conclusion. The application of the “dried blood spot” method using newly developed protocols for taking, storing and analyzing biological samples, relieves the existing constraints in conducting TDM, and can later become a promising method for conducting preclinical and clinical studies.
SAFETY STUDY OF ROMIPLOSTIM BIOSIMILAR
Authors: Afanasyeva A. N. , Saparova V. B. , Karal-Ogly D. D. , Mukhametzyanova E. I. , Kurkin D. V. , Kalatanova A. V. , Makarenko I. E. , Khokhlov A. L. , Lugovik I. A.
Published: November 2022

Idiopathic thrombocytopenic purpura is a chronic autoimmune hematological disease caused by an increased destruction of platelets and associated thrombocytopenia, for the treatment of which the imported drug romiplostim is used. Сreation of the drug biosimilar provides a reduction in the cost of therapy and an access for the treatment to more patients.

The aim of the study was to compare the safety indicators of the reference drug and its biosimilar in vivo and in vitro.

Materials and methods. In the in vitro study, a model of “complement-dependent cytotoxicity” induced by the complement was formed on the 32D hTPOR clone 63-cell line, followed by a cell viability measurement with the CellTitter Glo® kit. An in vivo part of the study was carried out on Javanese macaque monkeys (Macaca fascicularis). During the experiment, the clinical condition, mortality, appetite of the animals, their body weight, body temperature, respiratory rate were assessed, the clinical parameters of blood and urine of the animals were also monitored, and the hemostasis indicators were additionally measured.

Results. In the in vitro experiment, the original drug romiplostim and its biosimilar GP40141 were compared in terms of EC50 values. The indicatirs did not show complement-dependent cytotoxicity. According to the in vivo results, no deviations were recorded in the clinical status of the animals and their feed intake, and no lethality was fixed out in the groups either. For all the parameters studied (body weight and temperature, respiratory rate, clinical urinalysis, clinical and biochemical blood tests, coagulation hemostasis), GP40141 and romiplostim, when administered at the doses equivalent to 10 toxic doses (TDs), had comparable effects.

Conclusion. In the comparison of safety performance both in vitro and in vivo, the original drug romiplostim and its biosimilar GP40141 showed similar results.
La tomografía de coherencia óptica en el diagnóstico y evolución de la coroidopatía lúpica. Reporte de caso
Authors: Barriga-Salaverry Guillermo
Published: November 2022

El lupus eritematoso sistémico (LES) es una enfermedad autoinmune que afecta múltiples órganos incluidos los ojos. Entre las manifestaciones oculares del LES se encuentra la coroidopatía lúpica (CL), afección poco frecuente, pero de importantes repercusiones visuales si no se trata oportunamente. Se presenta el caso de una paciente de 41 años que desarrolló una CL durante la reducción de su terapia corticoesteroidea para el LES, estudiada con angiofluoresceinografía retiniana y tomografía de coherencia óptica (OCT) para el diagnóstico y seguimiento de su compromiso ocular. Tanto las fugas del colorante como los desprendimientos serosos de retina cedieron con el tratamiento de altas dosis de prednisona, pero recurrieron en dos oportunidades a pesar del control de la enfermedad de fondo. Se enfatizan las características clínicas para permitir su reconocimiento, resaltando el uso de la OCT para su diagnóstico y seguimiento luego del tratamiento.
Remote teaching and inclusive education: approximations with Universal Design for Learning
Authors: Costa-Renders Elizabete Cristina , Sous Debora de Lourdes da Silva , Bresciani Ana Carolina Valverde
Published: November 2022

This article results from the approximation between two researches in the area of education: a scientific initiation research with promotion of FAPESP and a master’s survey at PPGE/USCS. Both were based on the paradigm of inclusion and the principles of the Universal Design for Learning and were carried out in the context of the closure of schools due to the COVID-19 pandemic between 2020 and 2021. The objective was to promote an interface between UDL principles and the curriculum approach in emergency remote teaching. It was empirical investigations that combined narrative research and development research and as instrument were held wheels of conversations with teachers working in the great ABC Paulista. Among the results, stands out the fact that remote teaching places light on the great social and educational inequality in Brazil, evidenced, for example, by the development of asynchronous remote teaching in printed material, something contradictory in a digital society. In addition to this need to remove digital barriers, in remote teaching it was necessary to extend the degree of influence of the learner in the teaching process and the UDL supported teachers, as it minimizes the need for curricular adaptation.
Impacto del aislamiento social en el incremento de la frecuencia y grado de la depresión en los adultos mayores del Centro de salud Jesús Poderoso durante la pandemia de Covid 19 periodo de junio 2020 - junio 2021
Authors:   , Zevallos Del Pino Paola
Published: November 2022

Objetivos del estudio: Determinar si existe un incremento en la frecuencia y el grado de la depresión durante el aislamiento social en los Adultos Mayores del Centro de Salud Jesús Poderoso debido a la pandemia por COVID 19. Metodología: Se realizará un estudió teniendo un enfoque cualitativo, de tipo Observacional longitudinal descriptivo, la población estará conformada por los Adultos Mayores del Centro de Salud Jesús Poderoso. Se realizará un muestreo por conveniencia. Se aplicará un cuestionario para evaluar cualitativamente la gravedad de los síntomas y valorar los cambios del paciente deprimido, la escala de Hamilton para Depresión (HDRS) y la versión abreviada de la Escala de Depresión Geriátrica Yesavage (Geriatric Depression Scale, GDS). Para la recolección de la información en este proceso, se utilizará la base de datos en una hoja de cálculo de Microsoft Excel 2016 Windows 10. En el estudio se respetarán los principios éticos de confidencialidad y contará con la aprobación de los consentimientos informados de los participantes.
Probabilistic assessment of cereal-rye impacts on regional crop yield and soil carbon
Authors: Rai Teerath , Lee Nicole , II Martin Williams , Davis Adam , Villamil Marِía B. , Dokoohaki Hamze
Published: November 2022

Field research for exploring the impact of winter cover crops (WCCs) integration into cropping systems is resource intensive, time consuming and offers limited application beyond the study area. To bridge this gap, we used the APSIM model, to simulate corn (Zea mays L.) – rye – corn – rye and corn – rye – soybean (Glycine max L.) – rye rotations in comparison to corn – corn and corn – soybean rotations across the state of Illinois at a spatial resolution of 5 km × 5 km from 2000–2020 to study the impact of WCCs on soil organic carbon (SOC) dynamics and crop production. By propagating the uncertainty in model simulations associated with initial conditions, weather, soil, and management practices, we estimated the probability and the expected value of change in crop yield and SOC following WCC integration. Our results suggest that integrating cereal rye into the crop rotations did not incur any yield penalties, and on the contrary, imparted greater yield stability for corn across the state. It was found that the areas with low probability of increase in SOC (p < 0.75) respond equally well for soil carbon sequestration through long-term adoption of WCCs. Furthermore, the average simulated soil carbon sequestration rate was found to be higher than 0.4% as set by Lima Paris Action Agenda to meet sustainable development goals. This study presents the most complete uncertainty accounting of WCC benefits across broad region and provides greater insight into the spatiotemporal variability of WCCs benefits for increasing WCC adoption rate.
Improvised Dynamic Round-Robin Scheduling for Optimum Resource Utilization in Cloud Systems
Authors: Aradhya Suvarna N , Priya Rashmi
Published: November 2022

Task Scheduling for optimum utilization of resources (CPU, Memory, Bandwidth, etc.) implies executing maximum number of tasks using minimum of resources. In large scale Cloud Computing and its associated architectures (Fog/Edge/IoT) used for new business models to provide uninterrupted services with intermittent connections to cloud servers, resource optimization plays a critical role as it determines the quality of service (QoS) offered to customers. Consequently, task scheduling for parallel processing is fundamental to understanding Resource Utilization, Inter-Process Communication, Network Latency, Load Balancing, Job Migration and Fault Tolerance. In this paper, an effort is made to explore, optimize and analyse usage of computing resources through implementation of scheduling algorithms on a cloud scenario. The results are construed with respect to several performance indicators that affect the QoS.
Uncertainty in child custody cases after parental separation: context and decision-making process
Authors: Mendes Josimar Antônio de Alcântara , Ormerod Thomas
Published: November 2022

Context factors (e.g., a family’s developmental crisis) can affect the child custody decision-making process and the child’s best interests after parental separation. But what are these context factors, and how can they vary across different cultures and legal systems? This paper reports a cross-cultural qualitative study funded by the Brazilian Ministry of Education and was carried out under a Naturalistic Decision-making approach. This study addresses context factors that impact the decision-making of experienced legal actors working in child custody cases. Interviews were conducted with 73 legal actors (judges, prosecutors, lawyers, psychologists and social workers) in Brazil and England. The data gathered were analysed employing a reflexive thematic analysis that generated seven themes addressing how uncertainty is structured by context factors in child custody cases after parental separation. The themes generated encompassed three domains (‘family’, ‘family court’ and ‘legal-psychosocial’) that draw attention to the sources of uncertainty in child custody cases, especially to the role of contextual players (family and children) in the child custody decision-making process.
Areas of enduring COVID-19 prevalence: drivers of prevalence and mitigating strategies.
Authors: Lewis Catherine , Johnson Sheena , Hartwig Angelique , Ubido Janet , Coleman Anna , Gartland Nicola , Kamal Atiya , Gaokar Amit , Armitage Chris , Fishwick David , Tongeren Martie van
Published: November 2022

Background: UK local authorities that experience sustained high levels of COVID-19 are described as areas of enduring prevalence (1). This research was carried out to investigate reasons for sustained high prevalence, along with mitigation strategies employed by Directors of Public Health, who lead public health teams.
Methods: Interviews were conducted with Directors of Public Health in 19 local authority areas across England, between July and November 2021. This included nine areas identified as areas of enduring prevalence and ten ‘comparison’ areas.
Results: The research suggests that health inequalities influence the wider picture of prevalence rates of COVID-19. Structural factors including deprivation, employment, and housing, due to the disproportionate impact on specific groups, converged with demographic factors including ethnicity and age, and vaccination rates, and were identified as key drivers of enduring prevalence. There are key differences in these drivers both within local authorities, and to a lesser extent, between areas of enduring prevalence and their comparison areas.
Conclusions: The research suggests that existing health inequalities influenced the wider picture of prevalence rates of COVID-19. Participants advised that more research is needed on the effectiveness of mitigation strategies, and to better understand the factors that drive prevalence. This would include an assessment of how these factors to combine to predict transmission, how this varies between different areas, and the relative importance of each
factor.
Risk factors of pulmonary complications in the patients with COVID-19: A case-control study
Authors: Eslamian Mohammad , Talebzadeh Hamid , Fasahat Amirhossein , Ghasemi Maryam , Seifnezhad Arsham , Zefreh Hamidreza , Sheikhbahaei Erfan , Parchami Koorosh , Nazemroaya Behzad , Tarrahi Mohammad Javad , Firouzfar Alireza , Esfahanian Fatemeh
Published: November 2022

Background
Pneumothorax (PTX), pneumomediastinum (PM), and emphysema (EM) are complications of SARS-CoV-2 infections. Studying these situations' risk factors, complications, and prognosis is essential for early diagnosis during a pandemic.
Methods
We performed a case-control study of patients diagnosed with coronavirus pneumonia complicated with PTX, PM, and EM compared with patients without these complications to evaluate the risk factors for the incidence and prognosis of patients with pulmonary complications of COVID-19. We used parametric, non-parametric, and regression tests to analyze the data.
Results
We enrolled 162 patients (81 complicated, 81 uncomplicated). A past medical history of diabetes mellitus (DM), hyperlipidemia (HLP), lung disease, and ischemic heart disease (IHD) was not associated with PTX, PM, and EM in COVID 19 pneumonia (p-value > 0.05). The mortality rate was higher in the case group (69% vs. 15%). Among ventilator modes, 46.2% of intubated patients in the case group had synchronized intermittent mandatory ventilation (SIMV) for their ventilation. ESR, CRP, D-dimer, LDH, WBC, and troponin significantly increased, and lymphocytes decreased in complicated COVID compared to control groups (p-value < 0.05).
Conclusion
The nature of SARS-CoV-2 predisposes patients to PTX and other pulmonary complications. In practice, we could predict the complications and severity of COVID-19 pneumonia from some specific laboratory data.
Condylar motion analysis - a controlled, blinded clinical study on the interindividual reproducibility of standardized evaluation of computer- recorded condylar movements
Authors: Ahlers M. Oliver , Petersen Tim , Katzer Lukasz D. , Türp Jens C. , Jakstat Holger A.
Published: November 2022

Objectives

The present study investigated to what extent systematic evaluation of electronic condylar motion recordings based on the Diagnostic Criteria for Dysfunction (DCD) leads to reproducible results in different examiners.

Methods

The study was based on the anonymized condylar motion recordings of 20 patients. These were recruited consecutively from the examinations in a center specializing in diagnosing and managing craniomandibular/temporomandibular disorders (CMD/TMD). Four trained practitioners independently evaluated the identical movement recordings of all patients after calibration. The evaluation was based on the previously published evaluation system. The CMDtrace software was used to record the results. The findings were then compared, and the matching values were determined (Fleiss' Kappa).

Results

The evaluation, according to Fleiss' Kappa, showed that the consistency of the assessment of the findings among the examiners is excellent (mean value 0.88, p < 0.00001).

Conclusion

The study shows that calibrated dentists achieved reproducible results using this evaluation system and computer-assisted reporting.

Clinical Relevance

Good reproducibility confirms the reliability of clinical motion analysis. The ambiguities uncovered and eliminated in the study should avoid misunderstandings in the future. Both factors establish the prerequisites for applying condylar motion analysis in clinical practice.
Aryl-to-Alkyl Radical Relay Heck Reaction of Amides with Vinyl Arenes
Authors: Du Yujia , Sheng Xiaxin , Li Junhua , chen Jiaming , Yang Sen , chen ming
Published: November 2022

A palladium-catalyzed aryl-to-alkyl radical relay Heck reaction of amides at α-C(sp3)-H sites with vinyl arenes is described. This process displays a broad substrate scope with respect to both amide and alkene components and provides access to a diverse classes of more complex molecules. The reaction is proposed to proceed via a hybrid palladium-radical mechanism. The core of the strategy is the fast oxidative addition of aryl iodide and fast 1,5-HAT overcome the slow oxidative addition of alkyl halides, and photoexcitation effect suppress the undesired β-H elimination. It is anticipated that this approach would inspire the discovery of new palladium-catalyzed alkyl-heck methods.