bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengelolaan Wakaf Produktif Dalam Bentuk Usaha Perikanan di Pondok Tidar Kota Magelang
Authors: Syamsuri Syamsuri , Bahrudin Bahrudin
Published: August 2022

Pesantren sebagai lembaga pendidikan Islam yang berdiri dan didirikan bersama masyarakat untuk masyarakat dan oleh masyarakat. Sehingga keberadaan dan orientasi pesantren sangat erat dengan mashlahah dan manfaat untuk masyarakat pada umumnya. Dalam prespektif ekonomi, pengelolaan harta wakaf di pesantren merupakan salah satu instrument yang mampu menyelesaikan masalah social ekonomi masyarakat. Walau bagaimanapun, dalam pelaksanaannya masih didapati beberapa nadzir yang belum mampu mengembangkan bahkan mengelolanya untuk memberdayakan masyarakat sekitar.Penelitian ini bertujuan untuk menjelaskan bagaimana wakaf produktif dikelola dan dikembangkan oleh Pondok Tidar. Pondok Tidar dipilih sebagai tempat penelitian dengan menggunakan purposive sampling, karena dampak mauquf alaihnya yang telah diwujudkan melalui pemberian beasiswa kepada para santri yang dhuafa’, mengelola dan mengembangkan wakaf produktif yang dianggap berisko tinggi yaitu perikanan yang berbasis aset wakaf. Penelitian ini mengunakan metode kualitatif yang disajikan secara diskriptif analitik, dianalisa secara “triangulasi” dan sumber data  melalui dokumentasi, observasi dan wawancara.Akhirnya penelitian ini mendapati bahwa PondokTidar telah melaksanakan prinsip-prinsip pemberdayaan ekonomi, baik dari segi perencanaan, pengorganisasian, pengelolaan sumberdaya manusia, kepemimpinan dan pengawasan, maka Pondok Tidar telah berhasil dalam mengelola dan mengembangkan wakaf secara produktif. Akan tetapi dalam pelaksanannya, Pondok Tidar mendapati beberapa hambatan yaitu personil SDM yang terbatas, pemahaman masyarakat tentang wakaf produktif. Dengan adanya penelitian ini diharapkan instisusi wakaf lebih kreatif dan inovatif dalam mengembangkan asset wakaf yang ada secara produktif dengan cara mengoptimalkan potensi yang ada baik dari SDM maupun kearifan local.
THE EXISTENCE OF THE SHIDDIQIYAH ORDER OF KALIBAGOR KEBUMEN AND ITS SOCIO-RELIGIOUS INFLUENCE
Authors: Fuadi Moh Ashif , Annuroni Ahmad Mudhofir , Fauziyah Ika Maula Nur
Published: August 2022

Penelitian ini membahas tentang kemunculan tarekat shiddiqiyyah di Desa Kalibagor Kabupaten Kebumen. Permasalahan yang akan dibahas adalah tentang sejarah, dinamika penyebaran, dan pengaruhnya dalam masyarakat. Berdasarkan permasalahan yang ada, penelitian ini tergolong penelitian sejarah yang secara metodologis dimulai dari pemilihan topik, pengumpulan sumber, verifikasi sumber, interpretasi data dan historiografi. Adapun metode penggalian data adalah observasi, Interwiew dan dokumentasi dengan menitikberatkan pada sumber primer berupa buku tarekat shiddiqiyyah, Interwiew, dan penelitian terdahulu. Penelitian ini menghasilkan kesimpulan bahwa Tarekat Shiddiqiyyah Kalibagor dibawa oleh Kiai Ja’far Shodiq, seorang khodamul ulum sepulangnya dari Pesantren Shiddiqiyyah Ploso Jombang. Masa perkembangan tarekat dimulai dengan berdirinya pesantren Mambā’ul Mubasysyirīn Majma’al Bahroin pada tahun 2001, yang menjadi pusat kegiatan shiddiqiyyah seperti kautsaran dan khalwat. Vonis tarekat ghoiru mu’tabar dan klaim sesat shiddiqiyyah di Kalibagor menjadi cair atas penjelasan dan bukti sanad tarekat. Eksistensi shiddiqiyyah Kalibagor mampu memberikan dampak positif terhadap perkembangan sosial keagamaan seperti dalam pendidikan pesantren, rutinan dzikir kautsaran bersama dan kegiatan santunan anak yatim membawa pengaruh masyarakat lebih agamis. [This research discusses the emergence of shiddiqiyyah orders in Kalibagor Village, Kebumen Regency. The issues that will be discussed are history, the dynamics of its spread, and its influence on society. Based on existing problems, this research is classified as historical research that methodologically starts from topic selection, source collection, verification, interpretation, and historiography. While the method of extracting data through observation, interviews, and documentation by focusing on the primary source in the form of shiddiqiyyah order books, interviews, and previous research. This research resulted in the conclusion that the Kalibagor shiddiqiyyah order was brought by Kiai Ja'far Shodiq, a khodamul ulum, after returning from the Shiddiqiyyah Pesantren Ploso Jombang, the period of development of the order began the establishment of the Mambā'ul Mubasysyirīn Majma'al Bahrain pesantren in 2001 which became the center of shiddiqiyyah activities such as kautsaran and khalwat, the verdict of the ghairu mu'tabar order and the false claims of shiddiqiyyah in Kalibagor became liquid on the explanation and evidence of the order sanad (transmission). The existence of shiddiqiyyah Kalibagor can have a positive impact on the development of religious society is realized in pesantren education, routine dhikr kautsaran together, and orphan compensation activities bring the influence of a more religious society.]
KONSEP MUQASAH PADA PEMBIAYAAN MURABAHAH DALAM PERSPEKTIF FATWA DSN-MUI
Authors: Sup Devid Frastiawan Amir , Suhendi Ifandi
Published: August 2022

Pembahasan tentang potongan angsuran, termasuk dalam definisi lain cashback atau potongan harga dalam pembiayaan murabahah, secara definitif, pelaksanaan, dan sistem pencatatannya, sudah lazim dikenal dengan sebutan muqasah. Mengenai pembiayaan murabahah, MUI telah membentuk DSN yang di antara tugasnya adalah mengeluarkan fatwa atas jenis-jenis kegiatan keuangan dan produk keuangan syariah, sekaligus mengawasi penerapan fatwa yang telah dikeluarkannya melalui DPS. Penelitian ini bertujuan untuk mendeskripsikan konsep muqasah pada pembiayaan murabahah dalam perspektif Fatwa DSN-MUI. Penelitian ini menggunakan metodologi kualitatif, deskriptif, dan kepustakaan. Hasil yang didapat, muqasah dalam pembiayaan murabahah dimungkinkan dapat terjadi dalam tiga kondisi, yaitu diskon dalam murabahah (Fatwa DSN No: 16/DSN-MUI/IX/2000), potongan pelunasan dalam murabahah (Fatwa DSN No: 23/DSN-MUI/III/2002), dan potongan tagihan murabahah (Fatwa DSN No: 46/DSN-MUI/II/2005). Adapaun metode dalam pemberiannya adalah diberikan pada saat pelunasan, yaitu LKS mengurangi piutang murabahah dan keuntungan murabahah, atau diberikan setelah pelunasan, yaitu LKS menerima pelunasan piutang dari nasabah dan kemudian membayarkan potongan pelunasannya kepada nasabah. [The discussion on installment discounts, including in other definitions of cashback or price discounts in murabaha financing, definitively, its implementation, and its accounting system, is commonly known as muqasah. Regarding murabaha financing, MUI has established a DSN whose duties include issuing fatwas on types of financial activities and Islamic financial products, as well as supervising the implementation of fatwas that have been issued through DPS. This research aims to describe the concept of muqasah in murabahah financing in the perspective of Fatwa DSN-MUI. This research used qualitative, descriptive, and literature methodology. The results obtained, muqasah in murabaha financing is possible in three conditions, namely discounts in murabaha (Fatwa DSN No: 16/DSN-MUI/IX/2000), repayment discounts in murabaha (Fatwa DSN No: 23/DSN-MUI/ III/2002), and discounts on murabaha installment (Fatwa DSN No: 46/DSN-MUI/II/2005). The method of giving it is given at the time of settlement, i.e. LKS reduces murabahah receivables and murabahah profits, or it is given after settlement, i.e. LKS receives repayment of receivables from the customer and then pays the repayment discount to the customer.]
Infrastruktur sebagai Dakwah: Muhammadiyah dan Bentuk Lain Dakwah
Authors: Haganta Karunia , Arrasy Firas , Nisa Muria Khusnun
Published: August 2022

Berbagai kajian yang dilakukan terhadap dakwah masih didominasi oleh dakwah dalam bentuk lisan maupun tulisan. Penggunaan media atau suatu tindakan juga sudah memperoleh perhatian sebagai bagian dari dakwah, meski masih belum sebanding dengan dakwah lisan dan tulisan. Artikel ini mengangkat pembangunan fasilitas publik yang dilakukan organisasi Muhammadiyah sebagai bentuk dakwah. Pembangunan fasilitas publik ini kerap dianggap sekadar wujud filantropi. Penulis melihat bahwa pembangunan fasilitas publik adalah bagian dari dakwah yang dilakukan Muhammadiyah. Dengan perspektif komunikasi dari James W. Carey dan komunikasi profetik, proses komunikasi tidak hanya dilihat dalam bentuk lisan, tulisan, atau gestur/tindakan, tetapi juga bentuk lain seperti materi, dalam konteks artikel ini adalah infrastruktur fasilitas publik, yang ditujukan sebagai pengamalan nilai-nilai profetik, termasuk di dalamnya adalah dakwah. Perspektif infrastruktur puitis dari Brian Larkin memungkinkan infrastruktur tidak hanya dilihat dari aspek fungsionalnya saja, tetapi juga aspek politisnya, termasuk nilai-nilai yang dibawa lewat pembangunan infrastruktur. Muhammadiyah dengan nilai Islam modern menerapkan dakwah Islam modern lewat fasilitas publik sesuai kebutuhan masyarakat, pendidikan campuran agama dan sains, dan Kawasan Tanpa Rokok (KTR). [Various studies conducted on da'wah are still dominated by da'wah in oral and written form. The use of media or an action has also received attention as part of da'wah, although it is still not comparable to oral and written da'wah. This article discusses the construction of public facilities by the Muhammadiyah organization as a form of da'wah. The construction of public facilities is often seen as just a form of philanthropy. We see that the construction of public facilities is part of the da'wah carried out by Muhammadiyah. With the communication perspective of James W. Carey and prophetic communication, the communication process is not only seen in the form of spoken, written, or gesture/action, but also other forms such as material, in the context of this article is the infrastructure of public facilities, which are intended as the practice of prophetic values, including da'wah. Brian Larkin's poetic infrastructure perspective allows infrastructure not only to be seen from the functional aspect, but also from the political aspect, including the values brought through infrastructure development. Muhammadiyah with modern Islamic values applies modern Islamic da'wah through public facilities according to community needs, education that is a mixture of religion and science, and Non-Smoking Areas (KTR).]
Implementasi Metode Ritme Otak untuk Meningkatkan Kualitas Menghafal Al-Qur’an di Rumah Tahfidz Assaubari Ponorogo
Authors: Hidayatusahiro Fatkul , Al Baqi Safiruddin
Published: August 2022

Menghafal Al-Qur’an bagi banyak orang adalah hal yang sulit karena banyak orang yang tidak tahu metodenya. Maka dari itu, untuk mempermudah cara cepat menghafal Al-Qur’an dan mengurangi ketidakmampuan para penghafal dalam menghafal Al-Qur’an, lembaga pendidikan masyarakat ingin membantu kepada seorang penghafal Al-Qur’an dalam melakukan kegiatan menghafal Al-Qur’an dengan memberikan solusi menggunakan Metode Ritme Otak agar lebih mudah, cepat, sistematis dan praktis. Guru memiliki peran penting dalam melaksanakan pendidikan. Urgensi penelitian yang dilakukan terhadap PAI adalah sebagai jembatan bahwa seorang guru mampu dan siap berperan dalam menjalankan peranannya, bahwa membaca atau menghafal Al-Qur’an merupakan ibadah yang paling agung, modal utama dalam mempelajari agama dan berdakwah, ikut serta dalam menjaga kemurnian Al-Qur’an, tadabbur dan tafakkur atas kebesahan Allah SWT.
EFFECTIVENESS OF USING THE TIKTOK APPLICATION AS A DIGITAL DAKWAH MEDIA FOR GENERATION Z (STUDY OF TIKTOK ACCOUNTS @Basyasman00)
Authors: Rochmah Nur Hafifah
Published: August 2022

Abstract: In this modern era, the existence of the use of social media has a significant influence on people's daily lives, especially Generation Z. This paper aims to determine the extent of the role of the Tiktok application as one of the platforms favored by Generation Z on the spread of values. Islamic valuesthrough the creator of the da'wah Husain Basyaiban. This research is included in the type of library research with a qualitative descriptive approach. The research data was obtained through direct observation on the TikTok account @Basyasman00 as well as documentation on uploaded posts to see the activities of netizens including the number of followers, likes, comments, shares and video views. Furthermore, the data collected was analyzed using a content analysis approach (content analysis). The results show that da'wah through the TikTok application is quite effective in reaching generation Z. The TikTok application is a surefire way to spread Islamic values today, especially for generation Z because of the great interest in knowledge about religion which is presented in a unique, interesting, and interesting way. and contemporary. The content that is in great demand by Gen Z is about solving the current issues that are booming as well as light topics that are closely related to the daily lives of teenagers. Keywords: TikTok, Generation Z, Digital Da'wah, Husain Basyaiban.
MORAL MESSAGE OF L.A. LIGHTS ADVERTISEMENT “JANGAN MAU DIADU, JANGAN MAU DIPECAH”
Authors: Assiddiki Rifki , Faristiana Andhita Risko
Published: August 2022

ABSTRACT: The purpose of this research is to determine the moral message and to find out the meaning of denotation, connotation, and to find out the myth of L.A. Cigarette advertising. The data collection technique used a semiotic analysis research method from Roland Barthes. The results of the analysis of the data found indicate that the moral message contained in this study reflects the life of a person, both from the lower middle class or the upper middle class, must be able to face problems and not leave problems and not leave problems but solve problems so that they will be resolved soon. The meaning of denotations, connotations, and myths in this study is that each individual must have an attitude of solidarity, responsibility, reciprocal forgiveness, be oneself, regret actions when making mistakes, dare to take risks, and be confident.Keywords: Moral Message, Advertising, LA Lights
KEBERHASILAN IBU SINGLE PARENT DALAM MENGATASI KENAKALAN ANAK AKIBAT PUTUS SEKOLAH DI DESA MADIGONDO KECAMATAN TAKERAN KABUPATEN MAGETAN
Authors: Shofiani Imas
Published: August 2022

Fenomena single parent yang terdapat di Desa Madigondo, Kecamatan Takeran, Kabupaten Magetan, mengharuskan seorang Ibu memiliki peran ganda yaitu selain mengurus dan membesarkan seorang anak, juga sebagai pencari nafkah, pendidik, dan pelindung. Ditambah lagi dengan keadaan anak yang mengetahui ketidakhadiran seorang ayah dan memasuki usia remaja. Penelitian ini menjelaskan (1) bentuk-bentuk kenakalan anak akibat putus sekolah yang diasuh oleh ibu single parent, (2) upaya ibu single parent dalam mengatasi kenakalan anak akibat putus sekolah, dan (3) bentuk keberhasilan ibu single parent dalam mengatasi kenakalan anak akibat putus sekolah di Desa Madigondo, Kecamatan Takeran, Kabupaten Magetan. Dengan fokus tersebut, dapat ditemukan bentuk-bentuk kenakalan anak akibat putus sekolah, upaya Ibu single parent dan keberhasilannya dalam mengatasi kenakalan anak akibat putus sekolah di Desa Madigondo, Kecamatan Takeran, Kabupaten Magetan. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Hasil penelitian menunjukkan (1) bentuk-bentuk kenakalan anak akibat putus sekolah dapat dan tidak dapat digolongkan pada pelanggaran hukum, (2) usaha Ibu single parent dalam mengatasi kenakalan anak dikelompokkan menjadi pencegahan, pengentasan, pembetulan, dan penjagaan yang diterapkan di lingkungan keluarga, masyarakat dan sekolah, (3) bentuk keberhasilan Ibu single parent dalam mengatasi kenakalan anak akibat putus sekolah dapat dilihat dari perubahan perilaku untuk menjadi lebih baik.
Morphine and dexamethasone-incorporated cocktail regimen for postoperative pain in patients undergoing primary total knee arthroplasty: a randomized controlled trial
Authors: Gong Ying , Gong Jian , Li Yuancheng , Liu Shi , Xu Cui
Published: August 2022

Background
This study was conducted to evaluate the pain-reducing efficacy and safety of morphine and dexamethasone-incorporated cocktail regimen in patients undergoing total knee arthroplasty (TKA).
Methods
This study enrolled 213 patients and randomly assigned them to one of three groups. Group I patients were injected with morphine, dexamethasone, bupivacaine, flurbiprofen axetil, and normal saline. Patients in group II were injected with dexamethasone, bupivacaine, flurbiprofen axetil, and normal saline. Patients in control group were administered bupivacaine, flurbiprofen axetil, and normal saline. To compare the pain-controlling efficiency, the visual analog scale (VAS) score, active and passive range of movement (ROM), rescue analgesia use, and 1-min walking distances were recorded and evaluated. Indicators of inflammation include serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) levels, and white blood cells count (WBC) were tested and compared. The following side effects were monitored: headache, dizziness, nausea, vomiting, wound leakage and wound infection.
Results
Group I patients had the lowest VAS and the highest active and passive ROM. In Group I, the VAS reduced from day one to four, but the ROM increased. Group II patients had a smaller reduction in VAS and a smaller increase in ROM, compared with the patients in control group. Patients in group I required the least rescue analgesia use in the first 48 hours postoperative and demonstrated the best walking abilities on postoperative day 2 and day 4. Indicators of inflammation were similar in all enrolled individuals. Following side effects were not recorded: headache, dizziness, nausea, and vomiting. Wound leakage was observed in four patients in group I (two patients) and group II (two patients). No wound infection symptoms were detected.
Conclusions
Morphine and dexamethasone-incorporated cocktail regimen efficiently reduced postoperative pain in patients undergoing primary TKA.
Trial registration:
Randomized controlled trial ISRCTN25027558, registered retrospectively on 27/02/2022. ( https://www.isrctn.com/ISRCTN25027558 )
Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi-Mgahinga and Queen Elizabeth in Western Uganda
Authors: Ochieng James Robert , Bachs Marta Planellas , Nsubuga Anthony , Rwego Innocent B. , Kisakye John Joseph M. , Riba Laura Muro , Figueres Jesus Muro
Published: August 2022

Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that share identical home ranges with livestock and serve as parasite link between livestock and humans. This study evaluates the prevalence of CAT in dogs in the Bwindi-Mgahinga and Queen Elizabeth conservation areas. This information will be useful to evaluate the possible role of dogs in the transmission cycle of Trypanosoma species in livestock and wild animals. Trypanosome tests using microhaematocrit centrifugation/dark ground microscopy technique (MHCT) followed by conventional polymerase chain reaction (cPCR) were performed in blood samples collected from identified indigenous dogs (n = 124). Four (3.23 %) out of 124 dogs were positive for CAT. One dog was positive with Trypanosoma congolense and three with T. vivax. There was no significant statistical difference in CAT prevalence rate in relation to dog’s age, sex and site (P > 0.05). This study reports what we believe is the first-time detection of T. congolense and T. vivax in the indigenous dogs found in the Bwindi-Mgahinga and Queen Elizabeth conservation areas in western Uganda. The noticed T. congolense and T. vivax could be responsible for both canine and animal trypanosomiasis and represents a serious threat to the livestock industry. Therefore, there is a need for continuous trypanosomiasis surveillance and integrated management in contiguity to wildlife reserves.
Quantum Error Mitigation by Pauli Check Sandwiching
Authors: Gonzales Alvin , Shaydulin Ruslan , Saleem Zain , Suchara Martin
Published: August 2022

We describe and analyze an error mitigation technique that uses multiple pairs of parity checks to detect the presence of errors. Each pair of checks uses one ancilla qubit to detect a component of the error operator and represents one layer of the technique. We build on the results on extended flag gadgets and put it on a firm theoretical foundation. We prove that this technique can recover the noiseless state under the assumption of noise not affecting the checks. The method does not incur any encoding overhead and instead chooses the checks based on the input circuit. We provide an algorithm for obtaining such checks for an arbitrary target circuit. Since the method applies to any circuit and input state, it can be easily combined with other error mitigation techniques. We evaluate the performance of the proposed methods using extensive numerical simulations on 1,850 random input circuits composed of Clifford gates and non-Clifford single-qubit rotations, a class of circuits encompassing most commonly considered variational algorithm circuits. We observe average improvements in fidelity of 34 percentage points with six layers of checks.
Polyamide membrane pretreatment combined with UPLC–MS/MS for the determination of industrial dyes in grain and meat products
Authors: He Yahui , Liu Xinyu , Zhu Yao , Liu Yajie , Li Lu , Wang Jing , El-Aty A. M. Abd
Published: August 2022

Herein, ultra-performance liquid chromatography-tandem four-stage mass spectrometry (UPLC–MS/MS) combined with a novel polyamide membrane extraction was used to rapidly determine industrial dyes in grain and meat products. Polyamide was used as an adsorbent in the membrane. When the sample was treated by the polyamide membrane, the industrial dyes were absorbed by the N-propyl Ethylenediamine (PSA) into the polyamide membrane, while most other ingredients were passed through the membrane. Then, the industrial dyes were eluted from the polyamide membrane by different solvents to be analyzed by UPLC–MS/MS. The novel pretreat method will reduce the time of the whole process to less than 30 minutes. The recovery of the dye was between 71% and 126%, and the precision was between 3 and 13. The results showed that the polyamide membrane can be used as a pretreatment method for detecting multicomponent industrial dyes in grain and meat products, which is rapid, simple, reliable and accurate.
Highly water-dispersed composite of cellulose nanofibers and boron nitride nanosheets
Authors: E Songfeng , Zhao Ruixia , Ning Doudou , Ma Qin , Geng Bo , Liu Jiayi , Lu Zhaoqing
Published: August 2022

In this work, a composite of cellulose nanofibers (CNFs) and boron nitride nanosheets (BNNSs) with high dispersity in water is prepared via the combination of ball-milling and high-pressure homogenization, which is then transformed into paper-like film by vacuum assisted filtering and drying. The obtained CNF/BNNS dispersions can stably exist over 30 days without the observation of sediments. CNFs as a medium of ball-milling can protect the exfoliated BNNSs from being reaggregation and severely destroyed in violent collisions, and the BNNSs and CNFs can promote their exfoliation with each other. The hydrophilicity and electrostatic repulsion of CNFs, as well as the strong interfacial interactions and stereo-hindrance effects between one-dimensional (1D) CNFs and two-dimensional (2D) BNNSs are the reasons for the high dispersity of the composite in water, which in turn results in the favorable mechanical properties of the formed films. Although the introduction of BNNSs lowers the stress, strain, and toughness of the neat CNF films, but increases their modulus due to the stiffness of BNNSs. However, the thermal conductivities of the homogenized samples are inferior to the unhomogenized ones, as the decreased lateral sizes and excellent dispersibility of BNNSs are unfavorable to the formation of connective path of thermal conduction.
Ranolazine attenuates brain inflammation in a rat model of type 2 diabetes
Authors: Cassano Velia , Tallarico Martina , Armentaro Giuseppe , De Sarro Caterina , Iannone Michelangelo , Leo Antonio , Russo Emilio , Citraro Rita , De Sarro Giovambattista , Hribal Marta Letizia , Sciacqua Angela
Published: August 2022

Recent studies suggest a pathogenetic association between metabolic disturbances, including type 2 diabetes (T2DM), and cognitive decline and indicate that T2DM may represent a risk factor for Alzheimer disease (AD). There are several experimental evidence that ranolazine, an antianginal drug, may act as a neuroprotective drug. The aim of the present study was to evaluate the effects of ranolazine on hippocampal neurodegeneration and astrocytes activation, in a T2DM rat model. Diabetes was induced by high fat diet (HFD) and streptozotocin (STZ) injection. Metformin, a widely employed hypoglycemic drug, has been used as positive control. Animals were divided into the following groups: HFD/STZ + Ranolazine, HFD/STZ + Metformin, HFD/STZ + Vehicle, NCD + Vehicle, NCD + Ranolazine, and NCD + Metformin. The presence of neurodegeneration was evaluated, in hippocampal cornus ammonis 1 (CA1) region, by cresyl violet staining histological methods, while astrocytes activation was assessed by Western blot analysis. Staining with cresyl violet highlighted a decrease in neuronal density and cell volume in the hippocampal CA1 area in of the diabetic HFD/STZ + Vehicle rats Ranolazine and Metformin both improved T2DM-induced neuronal loss and neuronal damage. Moreover, there was an increased expression of GFAP in HFD/STZ + Vehicle group, compared to either NCD and HFD/STZ animals receiving ranolazine or metformin. In conclusion, in the present study, we provided insights on the mechanisms through which ranolazine may counteract cognitive decline in diabetic patients.
The prognostic effect of chemosensitivity on brain metastases in small-cell lung cancer: A retrospective analysis
Authors: Ma Jintao , Meng Chunliu , Tian Jia , Ren Kai , Yan Meng , Xu Liming , Zhao Lujun , Wang Ping
Published: August 2022

Purpose: To investigate the prognostic differences between small-cell lung cancer (SCLC) patients with different chemosensitivity to first line chemotherapy who developed brain metastasis as first site of progression. Methods: Patients with brain metastases (BMs) after first-line treatment of SCLC in our hospital admitted from January 2012 to October 2020 were retrospectively analyzed. According to the time interval between the completion of first-line chemotherapy and the onset of BMs (TFI), the patients were divided into chemo-sensitive group (TFI ≥ 90 days, n = 145) and chemo-resistant group (TFI ＜ 90 days, n = 97). Survival time after the onset of brain metastasis (BM-OS), which was calculated from the diagnosis of brain metastases and overall survival (OS), which was calculated from the diagnosis of small-cell lung cancer, were analyzed in this study. Survival curves were plotted using Kaplan-Meier method and differences between groups were compared using the log-rank test. The Chi-square test or Fisher’s exact test was used to compare categorical variables. Results: In total, the median BM-OS and OS were 8.4 months and 18.2 months respectively. The median BM-OS in chemo-sensitive group was 8.8 months and it was 8.0 months in the chemo-resistant group (P = 0.538); and the median OS was 22.0 months and 15.6 months, respectively (P = 0.001). In patients without extracranial progression (n = 193), the median BM-OS in chemo-sensitive and chemo-resistant group were 9.4 months and 9.7 months (P = 0.947), and the median OS were 22.7 months and 16.3 months, respectively (P = 0.017). In patients with extracranial progression (n = 49), the median BM-OS were 5.4 months and 4.2 months (P = 0.161), and the median OS were 17.6 months and 12.3 months, respectively (P = 0.002). Conclusions: After the development of brain metastasis as the first site of progression following chemotherapy in small cell lung cancer, the prognosis of chemo-sensitive patients not necessarily superior to chemo-resistant patients, especially in patients without extracranial progression.
Abnormal Peripheral Blood Cell Counts in Neurofibromatosis Type 1
Authors: Nobeyama Yoshimasa , Yasuda Ken-ichi , Asahina Akihiko
Published: August 2022

Introduction:
Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant disease characterized by neurofibromas with infiltration of mast cells. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR) and basophil-to-lymphocyte ratio (BLR) are examined as markers for various diseases. However, these parameters have not yet been assessed for NF1. This study therefore examined these parameters in NF1 patients.
Methods
We recruited 153 NF patients (78 males, 75 females) and 51 control patients (31 males, 20 females). Complete blood counts were performed, then NLR, LMR, PLR and BLR were calculated.
Results
Neutrophil count was significantly higher in male NF1 patients than in male controls. Lymphocyte count was significantly lower in NF1 patients than in controls for both sexes. Monocyte count was significantly higher in male NF1 patients than in male controls. Basophil count was significantly higher in male NF1 patients than in male controls. NLR, PLR and BLR were significantly higher in NF1 patients than in controls for both sexes. LMR was significantly lower in NF1 patients than in controls for both sexes.
Conclusion
NF1 shows high NLR, PLR and BLR and low lymphocyte count and LMR.
Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice
Authors: Gonzaga Beatriz Matheus Souza , Horita Samuel Iwao Maia , Beghini Daniela Gois , Gomes Fabiana , Nisimura Líndice Mitie , Santos Isabele Barbieri , Estato Vanessa , Araújo-Jorge Tania Cremonini , Garzoni Luciana Ribeiro
Published: August 2022

Central nervous system alterations was described in Chagas disease in both human and experimental models, leading to meningoencephalitis, stroke and cognitive impairment. Recently, our group demonstrated that acute infection by Trypanossoma cruzi leads to cerebral microvasculophaty in mice with endothelial dysfunction, capillary rarefaction, increased rolling and leukocyte adhesion. Only benznidazole and nifurtimox are available for clinical treatment, they have an efficiency of 80% in the acute phase and less than 20% in chronic phase. However, the effect of these drugs on brain microcirculation has not yet been evaluated. We hypothesized that early treatment with benznidazole could protect brain microcirculation during acute experimental Chagas disease. Swiss Webster mice were inoculated with 104 trypomastigotes forms of T. cruzi, and after 24 h they were treated with 50 or 100 mg/kg/day of benznidazole for 14 consecutive days. In untreated infected mice, we observed cerebral microvascular rarefaction, increase in leukocyte rolling and adhesion, reduced cerebral blood flow, and increased CD3 + and F4-80 + cells in brain tissue. Early treatment with benznidazole at 100mg/kg/day and 50mg/kg/day prevented the occurrence of the alterations mentioned. Here, we show that BZ is able to protect the microcirculation and reduced brain inflammation in acute experimental Chagas disease.
Estimates of Prevalence, Time-Trend, and Association of Smoking in Adults Living with HIV, HBV, and HCV (NHANES 1999–2018)
Authors: Yang Jie , Lin Jin-Long , Liu Jing , Jiang Xiao-Wen , Zhang Hao , Peng Lei
Published: August 2022

Although the smoking rate of HIV, HBV or HCV infected people is much higher than that of the general population, smoking cessation interventions have long been ineffective. Therefore, further understanding of the underlying social reasons behind the poor behavior of this population is needed. We aimed to examine the estimates of prevalence, time-trend, and association of smoking among people living with HIV, HBV, or HCV. This cohort was composed of 32,115 individuals from the National Health and Nutrition Examination Survey (NHANES 1999–2018). All adults aged 21–59 who self-reported smoking status and had been tested for HIV, HBV, and HCV were included in this analysis. The time trend analysis of smoking and quitting rates in different years of survey follow-up and different infected populations. Multivariable logistic regression analysis was used to identify the risk factors related to smoking behavior of HIV|HBV|HCV infected people. Overall, the smoking rates of the people infected HIV|HBV|HCV were 1.35–1.93 times higher from 1999 to 2018. Compared to smokers without HIV&HBV&HCV, smokers living with HIV|HBV|HCV were more likely to be older (aged 30–39, 9.92, 6.07 to 16.21; aged 40–49, OR = 3.51, CI = 2.49 to 4.94), more males (1.99, 1.54 to 2.55), lower education level (1.78, 1.39 to 2.29), lower economic level (2.05, 1.59 to 2.65), unemployed (1.63, 1.21 to 2.20), suffering depression (1.35, 1.05 to 1.72), and drug users (7.65, 5.04 to 11.59). Taken together, studies have shown that complex psychosocial characteristics and behavioral factors, including individual economic status, mental diseases (such as depression) and illegal drug use (such as marijuana and heroin) hinder their efforts to quit smoking. Therefore, it is very important to take targeted smoking cessation interventions to meet the unique situation and needs of this special group.
Establishment and Validation of the Nomogram Model for Mortality Risk in Patients with Dangerous Upper Gastrointestinal Bleeding
Authors: Liu Zhou , Zhang Liang , Bai Wen-hui , Cheng Li , Zhan Li-ying , Wang Pei-xue , Jiang Gui-jun , Dong Wei-guo
Published: August 2022

Objective A Nomogram model was established to predict the mortality risk for patients with dangerous upper gastrointestinal bleeding (DUGIB), aimed at identifying those high-risk one who required emergency treatment. Methods Collected the clinical data of 256 DUGIB patients who were admitted to Intensive Care Unit (ICU) of Renmin Hospital of Wuhan University from January 2020 to April 2022. A total of 179 patients admitted to ICU were treated as training cohort, while 77 patients who were admitted to ICU of East Campus were considered validation cohort. Multivariate logistic regression analysis was performed to determine the independent risk factors, and R packages were used to construct nomogram model. The prediction accuracy and identification ability were evaluated by receiver operating characteristic curve (ROC), C index and calibration curve. Furthermore, the clinical value of the model was evaluated by decision curve analysis (DCA). Simultaneously, the model was externally validated. Results A total of 256 patients diagnosed with DUGIB were included, among which 67 patients (19.14%) eventually died. Multivariate logistic regression analysis suggested that hematemesis, urea nitrogen level, emergency endoscopy, AIMS65 score, GBS and Rockall score were all independent risk factors. ROC curve analysis showed the area under the curve (AUC) of training cohort was 0.980 (95% CI : 0.962~0.997), while validation cohort was 0.790 (95% CI : 0.685~0.895). The calibration curves for both training and validation cohorts were then tested by Hosmer-Lemeshow Goodness ( P =0.778, P =0.516). To summarize, the Nomogram prediction model was of great clinical value. Conclusion The nomogram was proven to be an effective tool for the risk stratification of DUGIB patients, and was also helpful for the early identification and intervention, especially in ICU.
A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for Osimertinib
Authors: Yin Yanchao , Shu Yamin , Zhu Junru , Li Feie , Li Juan
Published: August 2022

Background
Osimertinib was a third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), which approved by the US Food and Drug Administration (FDA) in 2015 for treatment of non-small cell lung cancer (NSCLC). Our study was to explore the adverse events (AEs) caused by osimertinib through data mining of the US FDA Adverse Event Reporting System (FAERS), and provide reference for clinical safety.
Methods
Data of osimertinib were collected from the FAERS database covering the period from first quarter of 2016 to the fourth quarter of 2021. Disproportionality analyses was employed to quantify the associated AE signals of osimertinib and detect the risk signals from the data in the FAERS database. ROR was used to detect the risk signals from the data in the FAERS database. The definition relied on system organ class (SOCs) and preferred terms (PTs) by the Medical Dictionary for Regulatory Activities (MedDRA).
Results
Totally, 9704338 reports were collected from the FAERS database, 10804 reports of osimertinib were identified as the ‘primary suspected (PS)’ AEs. Osimertinib induced AEs occurred in 27 organ systems. 68 significant disproportionality PTs satisfying with the four algorithms were retained at the same time. Unexpected significant AEs such as scrotal volvulus, hepatic function abnormal, VTEs might also occur. The median onset time of osimertinib-associated AEs was 58 days (interquartile range [IQR] 14–212 days), and the majority of the AEs occurred within the first 30 days after osimertinib initiation.
Conclusion
Our study found significant new AEs signals of osimertinib and might provide support for clinical monitoring and risk identification of osimertinib.
Effect of Zn(II) on pramlintide: structural kink, fibril formation, antifungal activity
Authors: Dudek Dorota , Dzien Emilia , Watly Joanna , Matera-Witkiewicz Agnieszka , Mikolajczyk Aleksandra , Hajda Agata , Olesiak-Banska Joanna , Rowinska-Zyrek Magdalena
Published: August 2022

The antimicrobial properties of amylin, a polypeptide secreted by the pancreas, are far less known than its antidiabetic function. Among the studied amylin analogues, the coordination of zinc(II) enhances the antifungal properties of pramlintide, a non-fibrillating therapeutic analogue of amylin; binding at the N-terminal amino group and His18 imidazole, it induces a kink in the peptide structure, which, in turn, triggers a fibrillization process of the complex, resulting in an amyloid structure most likely responsible for the disruption of the fungal cell.
A Novel HVgP and OLBP approach in Distributed Transaction Partitioning
Authors: R.D.Bharati R.D.Bharati , V.Z.Attar V.Z.Attar
Published: August 2022

Data partitioning acts an important role in Online Transaction Processing (OLTP) to enhance their performance and scalability. Partitioning is important in OLTP based systems due to the increase of user populations and online transactions. Nowadays, providing scalable and reliable data organization is the main aim of database researchers. This work presented an innovative data partitioning approach and optimized load balancing for scalable transactions. Initially, the Hybrid Vertical-graph partitioning (HVgP) approach is utilized for appropriate data partitioning. After the process of data partitioning, the partitions efficiency and the average workload parameters are computed and their corresponding weight factor is computed. Subsequently, Optimized Improved Load Balancing (OLBP) algorithm is utilized for scalable OLTP data transactions on distributed database. Here, the estimated weight factor is updated for effective load balancing with data partitions. The presented approach is appropriate for various online data transaction applications. The quality of the presented approach is examined using TPC-E OLTP benchmark dataset. The performance of the improved approach is examined with the different existing approaches and proved the significant enhancement in different performance metrics like Throughput, Response time, distributed transactions, and CPU utilization.
Parallel Social Group Optimization (Psgo): Performance and Its Application to Routing in Wmn’s
Authors: Sharma Bhanu , Singh Amar
Published: August 2022

This paper proposes a new multi-population-based social optimization technique called Parallel Social Group Optimization (PSGO). The algorithm is inspired by the learning behaviour of humans in different groups. In this algorithm, we consider the complete process of human interaction within the group and outside the group. We implement the proposed algorithm in MATLAB and tested it on 30 standard benchmark functions. For performance analysis purposes, we compare the PSGO algorithm with other recent 16 algorithms. The PSGO algorithm outperformed the other 16 algorithms on 4 standard benchmark functions. None of the other algorithms could match this performance. In addition, for functions f1,f2, f3,f4,f5, and f7of standard benchmark functions it produced the best performance but this performance was equalled by a few other algorithms also. Further, we propose a PSGO-based dynamic route evaluation approach for Wireless Mesh Networks (WMNs). We implemented the PSGO-based routing approach in MATLAB and compared it with 9 soft computing and hard computing-based approaches namely AODV, DSR, ACO, BBO, BAT, Firefly, BBBC, GA, and SGO. On over 1500 dynamic node network situations, the PSGO-based routing technique outscored all other 9 algorithms.
The Effect of Coriander Oil Addition to Goat Feed on the Technological Properties of the Resultant Milk; Rayeb as a Product Model
Authors: Abd-Rabou Hagar S. , Mahmoud Hanem M. , Matloup O. H. , Sallam S. M. , Elazab M.A.
Published: August 2022

Goat milk is an essential alternative milk resource for those suffering from cow and buffalo milk allergies and is considered a nutrient protein source for children and neonates. This paper aims to answer the question: Does adding crude coriander oil to goats' food affect the quality of their milk and the properties of their products? Study the chemical, rheological, and microbiological properties and the acceptability of probiotic goat's rayeb milk. Two coriander oil concentrations were used in the study; a low level of 0.95% (T1) and a high level of 1.9% (T2). The results declared that coriander oil did not affect the coagulation time, which was almost six hours for all batches. At the same time, the apparent viscosity decreased significantly (p ≤ 0.05) in T2 with the high oil level. Moreover, treatments showed a significant (p ≤ 0.05) increase in the content of monounsaturated fatty acids and a decrease in polyunsaturated fatty acids. Low-level oil supplementation showed the best rayeb properties, surpassing the control treatment in most properties and higher sensory scores.
First documented case of thrombolysis in a teaching hospital in Ghana: challenges to early intervention in acute infarctive stroke in developing countries
Authors: Duodu F. , Pekyi-Boateng Prince , Agbinko-Djobalar Babbel , Mends David Brodie , Nkromah Kodwo , Adjei Patrick , Akpalu Albert
Published: August 2022

Background
We report a case of an elderly woman who developed an Ischemic stroke. Thrombolytic therapy was successful as evidenced by functional and neurological improvement. This is the first well-documented case of such intervention in Korle-Bu Teaching Hospital (KBTH), Stroke unit.
Case Information:
Our patient is a 64-year-old woman who is known to have hypertension and diabetes. She had been relatively well until she developed an ischemic stroke. Five days prior to this, she had experienced two episodes of Transient Ischemic Attacks (TIA). Thrombolytic therapy was successful with Tenecteplase given at 4.5 hours post-episode. MRS (Modified Ranking Scale) and NHISS (National Health Institute of Stroke Scale) pre thrombolysis were 4 and 10 respectively. NHISS 2hrs post thrombolysis was 4. MRS and NHISS 24hrs post thrombolysis were 0 and 1 respectively. We sought to identify why only a few cases of thrombolytic therapies are carried out in developing countries, and we found that the strict eligibility for the initiation of therapy was the main barrier.
Conclusion
In acute infarctive stroke management, intervention is time-dependent, as thrombolysis has been shown to prevent permanent disability if instituted early enough. We believe that many more individuals may benefit from thrombolytic therapy if more studies are carried out with systematic reviews of case reports and research, factoring in key challenges met in middle to low-income countries.
Orthostatic hypotension is associated with malnutrition diagnosed by GLIM in elderly hypertensive patients
Authors: Zhang Qizhe , Shen Shanshan , Guan Huilan , Zhang Jingmei , Chen Xujiao
Published: August 2022

Background:Orthostatic Hypotension (OH) and malnutrition, are common health problems in elderly hypertensive patients. This study aimed to analyze the relationship between malnutrition and OH in elderly hypertensive patients. Methods:This is a cross-sectional single-center study. All participants underwent a Comprehensive Geriatric Assessment (CGA), in which malnutrition was defined according to the Global Leadership Initiative on Malnutrition (GLIM) criteria based on four different methods of diagnosing muscle mass loss. Furthermore, the accuracy of these methods was verified by Receiver Operating Characteristic (ROC) analysis. Univariate and multivariate logistic regression analyses were used to identify risk factors for OH in elderly hypertensive patients. Results: For GLIM criteria, when Fat-Free Mass Index (FFMI) was the gold standard for muscle mass loss, the Area Under ROC Curve (AUC) values for Upper Arm Circumference (UAC), Calf Circumference (CC), and Hand Grip Strength (HGS) were 0.784, 0.805, and 0.832, with moderate accuracy in diagnosing malnutrition. Multivariate analysis showed that females, Diabetes Mellitus (DM), diuretics, and malnutrition diagnosed by GLIM-UAC were risk factors for OH in elderly hypertensive patients. Conclusions: Prompt detection of malnutrition in the elderly and attention to changes in UAC may be critical. Similarly, we should strengthen medication and disease management in elderly hypertensive patients.
On the Political Economy of Conflicts in the Middle East and Africa
Authors: Parent Olivier , Zouache Abdallah
Published: August 2022

In this paper, we aim to identify the main factors that explain the occurrence and intensity of armed conflicts in a specific region, the Middle East and North Africa. We extend the linear Bayesian Model Averaging procedure to allow for the outcome, conflict intensity, to be measured on an ordered scale. Our research led us to expand the traditional dichotomous outcome, war versus peace, into a conflict intensity measure dissociating the state of peace from four different levels of violence. We provide strong evidence that not only demographical, institutional and socio-economic but also, environmental factors must be considered when analyzing conflict intensity. Those factors being innately intertwined, we advise policy makers not to rely on a particular theory to assess policy decisions. By paying special attention to neighboring states’ characteristics, our results reveal that political economy factors, historical legacy, climate and access to natural resources are key in identifying conflict severity. Finally, we show that model averaging predictions for ordered categorical outcomes improve upon the existing out-of-sample conflict prediction techniques.JEL Codes: O11, O15, C11, C52
Characterizations of type 1 subdiagonal algebras and an application
Authors: Zhang Ruihan , Ji Guoxing
Published: August 2022

Let A be a maximal subdiagonal algebra in a σ-finite von Neumann algebra M with respect to a faithful normal conditional expectation Φ. We consider the characterizations for A to be a type 1 subdiagonal algebra in the sense that every right invariant subspace in noncommutative H2 space is of Beurling type. As an application, we give a necessary and sufficient condition that a nest subalgebra AlgN with an injective nest N is a type 1 subdiagonal algebra in a factor von Neumann algebra M.MSC Classification: 46L52 , 47L75 , 46K50 , 46J15