bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Predictive Models for COVID-19: Systematic Study (Preprint)
Authors: Schwab Patrick , DuMont Schütte August , Dietz Benedikt , Bauer Stefan
Published: October 2020

BACKGROUND

COVID-19 is a rapidly emerging respiratory disease caused by SARS-CoV-2. Due to the rapid human-to-human transmission of SARS-CoV-2, many health care systems are at risk of exceeding their health care capacities, in particular in terms of SARS-CoV-2 tests, hospital and intensive care unit (ICU) beds, and mechanical ventilators. Predictive algorithms could potentially ease the strain on health care systems by identifying those who are most likely to receive a positive SARS-CoV-2 test, be hospitalized, or admitted to the ICU.

OBJECTIVE

The aim of this study is to develop, study, and evaluate clinical predictive models that estimate, using machine learning and based on routinely collected clinical data, which patients are likely to receive a positive SARS-CoV-2 test or require hospitalization or intensive care.

METHODS

Using a systematic approach to model development and optimization, we trained and compared various types of machine learning models, including logistic regression, neural networks, support vector machines, random forests, and gradient boosting. To evaluate the developed models, we performed a retrospective evaluation on demographic, clinical, and blood analysis data from a cohort of 5644 patients. In addition, we determined which clinical features were predictive to what degree for each of the aforementioned clinical tasks using causal explanations.

RESULTS

Our experimental results indicate that our predictive models identified patients that test positive for SARS-CoV-2 a priori at a sensitivity of 75% (95% CI 67%-81%) and a specificity of 49% (95% CI 46%-51%), patients who are SARS-CoV-2 positive that require hospitalization with 0.92 area under the receiver operator characteristic curve (AUC; 95% CI 0.81-0.98), and patients who are SARS-CoV-2 positive that require critical care with 0.98 AUC (95% CI 0.95-1.00).

CONCLUSIONS

Our results indicate that predictive models trained on routinely collected clinical data could be used to predict clinical pathways for COVID-19 and, therefore, help inform care and prioritize resources.
Machine Learning Methods for the Diagnosis of Chronic Obstructive Pulmonary Disease in Healthy Subjects: Retrospective Observational Cohort Study (Preprint)
Authors: Muro Shigeo , Ishida Masato , Horie Yoshiharu , Takeuchi Wataru , Nakagawa Shunki , Ban Hideyuki , Nakagawa Tohru , Kitamura Tetsuhisa
Published: October 2020

BACKGROUND

Airflow limitation is a critical physiological feature in chronic obstructive pulmonary disease (COPD), for which long-term exposure to noxious substances, including tobacco smoke, is an established risk. However, not all long-term smokers develop COPD, meaning that other risk factors exist.

OBJECTIVE

This study aimed to predict the risk factors for COPD diagnosis using machine learning in an annual medical check-up database.

METHODS

In this retrospective observational cohort study (ARTDECO [Analysis of Risk Factors to Detect COPD]), annual medical check-up records for all Hitachi Ltd employees in Japan collected from April 1998 to March 2019 were analyzed. Employees who provided informed consent via an opt-out model were screened and those aged 30 to 75 years without a prior diagnosis of COPD/asthma or a history of cancer were included. The database included clinical measurements (eg, pulmonary function tests) and questionnaire responses. To predict the risk factors for COPD diagnosis within a 3-year period, the Gradient Boosting Decision Tree machine learning (XGBoost) method was applied as a primary approach, with logistic regression as a secondary method. A diagnosis of COPD was made when the ratio of the prebronchodilator forced expiratory volume in 1 second (FEV1) to prebronchodilator forced vital capacity (FVC) was <0.7 during two consecutive examinations.

RESULTS

Of the 26,101 individuals screened, 1213 met the exclusion criteria, and thus, 24,815 individuals were included in the analysis. The top 10 predictors for COPD diagnosis were FEV1/FVC, smoking status, allergic symptoms, cough, pack years, hemoglobin A1c, serum albumin, mean corpuscular volume, percent predicted vital capacity, and percent predicted value of FEV1. The areas under the receiver operating characteristic curves of the XGBoost model and the logistic regression model were 0.956 and 0.943, respectively.

CONCLUSIONS

Using a machine learning model in this longitudinal database, we identified a number of parameters as risk factors other than smoking exposure or lung function to support general practitioners and occupational health physicians to predict the development of COPD. Further research to confirm our results is warranted, as our analysis involved a database used only in Japan.
Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD
Authors: Chen Jing , Hamm L. Lee , Bundy Joshua D. , Kumbala Damodar R. , Bodana Shirisha , Chandra Sehgal , Chen Chung-Shiuan , Starcke Charlton C. , Guo Yajun , Schaefer Caroline M. , Lustigova Eva , Mahone Erin , Vadalia Aarti M. , Livingston Terra , Obst Katherine , Hernandez Jesus , Bokhari Syed Rizwan , Kleinpeter Myra , Alper Arnold B. , Lukitsch Ivo , He Hua , Nieman David C. , He Jiang
Published: October 2020

Background and objectives

Endothelial dysfunction is common among patients with CKD. We tested the efficacy and safety of combination treatment with sodium nitrite and isoquercetin on biomarkers of endothelial dysfunction in patients with CKD.

Design, setting, participants, & measurements

This randomized, double-blind, placebo-controlled phase 2 pilot trial enrolled 70 patients with predialysis CKD. Thirty-five were randomly assigned to combination treatment with sodium nitrite (40 mg twice daily) and isoquercetin (225 mg once daily) for 12 weeks, and 35 were randomly assigned to placebo. The primary outcome was mean change in flow-mediated vasodilation over the 12-week intervention. Secondary and safety outcomes included biomarkers of endothelial dysfunction, inflammation, and oxidative stress as well as kidney function, methemoglobin, and adverse events. Intention-to-treat analysis was conducted.

Results

Baseline characteristics, including age, sex, race, cigarette smoking, history of hypertension and diabetes, use of renin-angiotensin system blockers, BP, fasting glucose, lipid profile, kidney function, urine albumin-creatinine ratio, and endothelial biomarkers, were comparable between groups. Over the 12-week intervention, flow-mediated vasodilation increased 1.1% (95% confidence interval, −0.1 to 2.3) in the treatment group and 0.3% (95% confidence interval, −0.9 to 1.5) in the placebo group, and net change was 0.8% (95% confidence interval, −0.9 to 2.5). In addition, changes in biomarkers of endothelial dysfunction (vascular adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, vWf, endostatin, and asymmetric dimethylarginine), inflammation (TNF-α, IL-6, C-reactive protein, IL-1 receptor antagonist, and monocyte chemoattractant protein-1), and oxidative stress (oxidized LDL and nitrotyrosines) were not significantly different between the two groups. Furthermore, changes in eGFR, urine albumin-creatinine ratio, methemoglobin, and adverse events were not significantly different between groups.

Conclusions

This randomized phase 2 pilot trial suggests that combination treatment with sodium nitrite and isoquercetin did not significantly improve flow-mediated vasodilation or other endothelial function biomarkers but also did not increase adverse events compared with placebo among patients with CKD.

Clinical Trial registry name and registration number:

Nitrite, Isoquercetin, and Endothelial Dysfunction (NICE), NCT02552888
Glycoprotein hormone receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
Authors: Costagliola Sabine , Dias James A. , Gershengorn Marvin , Pawson Adam J. , Segaloff Deborah L. , Themmen Axel P.N. , Vassart Gilbert
Published: October 2020

Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].
СОВЕРШЕНСТВОВАНИЕ МОДЕЛИ БТИЗ ДЛЯ ИНТЕГРАЦИИ В ПРОГРАММУ СХЕМОТЕХНИЧЕСКОГО МОДЕЛИРОВАНИЯ
Authors: Кокин С.А. , Мальков С.В. , Осипов Е.О. , Перминов Д.В.
Published: October 2020

Усовершенствована модель БТИЗ, для которой решены проблемы сходимости математических алгоритмов при схемотехническом моделировании. В целях повышения точности моделирования электрофизических характеристик внесены дополнения в формульные описания компактной модели.
МЕТОД ПОВЫШЕНИЯ ТОЧНОСТИ СХЕМОТЕХНИЧЕСКОГО МОДЕЛИРОВАНИЯ НА ОСНОВЕ УЧЕТА LDE-ПАРАМЕТРОВ ДЛЯ ТЕХНОЛОГИИ 28 НМ
Authors: Надин А.С. , Тюрин А.В. , Шипицин Д.С.
Published: October 2020

В данной работе предложено решение (методология) по повышению точности моделирования и прогнозирования работы схемы в субмикронных технологиях 90 нм и ниже, способное корректно учитывать LDE-параметры на этапе pre-layout-моделирования.
АРХИТЕКТУРА SPICE-МОДЕЛЕЙ УЛЬТРАСОВРЕМЕННЫХ ГЛУБОКО-СУБМИКРОННЫХ МОП-ТРАНЗИСТОРОВ
Authors: Шипицин Д.С. , Потупчик А.Г. , Шемякин А.В.
Published: October 2020

Произведены обзор и анализ особенностей архитектуры SPICE-моделей МОП-транзисторов, выполненных по глубоко-субмикронным нормам проектирования (45 нм и менее). Рассмотрены подходы к учету статистических компонентов модели, а также основных, с точки зрения влияния на электрофизическое поведение МОП-транзистора, эффектов близости (LDE).
СОЗДАНИЕ ОТЕЧЕСТВЕННОЙ ПЛАТФОРМЫ САПР ДЛЯ ПРОЕКТИРОВАНИЯ СВЧ-УСТРОЙСТВ И ПОЛУПРОВОДНИКОВЫХ ИС
Authors: Бабак Л.И. , Коколов А.А.
Published: October 2020

Предлагается проект отечественной платформы САПР для проектирования СВЧ-устройств и полупроводниковых ИС. Использование унифицированных решений позволяет обеспечить совместимость САПР СВЧ для различных проектных задач, уменьшить затраты и время на разработку, облегчить эксплуатацию и освоение.
La perspectiva estudiantil sobre la reforma universitaria en cuatro instituciones públicas mexicanas
Authors: Rodríguez Lagunas Javier , Hernández Vázquez Juan Manuel
Published: October 2020

Este artículo muestra las percepciones del alumnado sobre los procesos de reforma educativa en cuatro universidades públicas: Universidad Autónoma Metropolitana (UAM), Universidad Autónoma de Nayarit (UAN), Universidad Autónoma de Tlaxcala (UATx) y Universidad Autónoma de Chiapas (UNACH), en particular referidos al currículo escolar, las prácticas docentes, el sentido de la formación profesional, la infraestructura y servicios universitarios, así como la participación estudiantil en las reformas educativas. Todo ello a propósito de las reformas sugeridas por las políticas hacia la educación superior. Se buscó explorar lo anterior con el análisis de cinco índices, construidos a partir de información de la encuesta RUPA 2014. Los resultados encontrados ayudan a comprender cómo participan del cambio los estudiantes universitarios y el modo en que las universidades públicas lo hacen suyo; se hacen aportes en torno a las dificultades que se presentan en el cambio educativo, tanto para las instituciones como para la comunidad universitaria.
La formación del profesorado ante los desafíos de la diversidad en Angola
Authors: Ndembele Suzana , Hernández de la Torre Elena
Published: October 2020

La formación de calidad para atender a la diversidad debe ser una de las prioridades políticas de un país frente al desafío de la equidad en una enseñanza para todos. El objetivo de este estudio es conocer las necesidades formativas del profesorado de enseñanza primaria de Angola para responder a la diversidad. La muestra se compone de 40 profesores de Angola, 20 de la provincia de Benguela y 20 de Namibe. Se utilizó un cuestionario con cinco categorías y cinco profesores de la provincia de Benguela participaron en un grupo focal. Los resultados apuntan a la necesidad de formación en inclusión educativa, metodologías abiertas y la utilización de medios didácticos en clase, lo que contribuiría a un cambio de actitud del profesorado en relación con el alumnado y la atención a la diversidad. La inclusión educativa es un proceso inacabado y un objetivo impostergable hacia una educación equitativa.
La voz de los estudiantes en riesgo de abandono escolar
Authors: Garrido-Miranda José Miguel , Polanco Madariaga Monserrat Norma
Published: October 2020

La exclusión escolar, en sus dimensiones de abandono y fracaso escolar, es una preocupación de los sistemas educativos debido al impacto negativo que tiene sobre niñas, niños y jóvenes provenientes de los sectores más vulnerables de la sociedad. Si bien, las investigaciones dan cuentan de diversas variables relacionadas con aspectos subjetivos, contextuales y sistémicos que afectan al estudiante que fracasa o deserta, poco se sabe sobre los significados y sentido de esta exclusión o sus factores desde la óptica de los propios estudiantes. Este trabajo informa de un estudio hermenéutico-interpretativo sobre la configuración y valoración de la figura del profesor que construyen estudiantes en riesgo de abandono escolar. A partir de entrevistas etnográficas semiestructuradas aplicadas a 49 estudiantes, emergen características relacionadas con actitudes y prácticas que llevan a los estudiantes analizados a construir una imagen dicotómica de lo que es un buen o un mal profesor.
Estado del ambiente de la Bahía San Julián, departamento Magallanes, Santa Cruz, Argentina
Authors: Pereyra Ginestar Blanca , Scavuzzo Viviana , Collm Natalia , Baudino Mario , Moscardi Carla
Published: October 2020

En la costa patagónica meridional, la bahía San Julián es un excelente espacio para las actividades recreativas y deportes náuticos. La zona de estudio abarca ambas márgenes, la costa occidental que tiene un mayor desarrollo de actividades urbanas y la costa oriental con menor actividad humana. Se releva parte de la información ambiental de la Bahía de San Julián con el propósito de evaluar su calidad ambiental a través de los sedimentos y el agua.Los sedimentos mareales actúan como entrampadores de los metales pesados y en función de su concentración pueden constituir zonas de contaminación relevantes. Conjuntamente, se analizan la presencia de hidrocarburos totales en agua. Se han realizado análisis bacteriológicos en el agua marina y se han registrado los parámetros fisico-químicos de la misma. Los censos de aves marinas y playeras por especie completan la investigación. Los resultados obtenidos indican que los valores de concentración para el Pb, Cu y Zn están por debajo de los rangos máximos permitidos de acuerdo a la normativa nacional e internacional vigente. No se ha detectado la presencia de hidrocarburos totales en aguas. En todas las estaciones, el muestreo bacteriológico acusó la presencia de bacterias coliformes totales especialmente en las zonas con impacto antrópico directo por la descarga de efluentes cloacales. Este tipo de disturbios influyen sobre la diversidad de aves ya que el gradiente basado en la disminución en la riqueza y un aumento en la abundancia, ocurre en la zona de los efluentes cloacales, especialmente en las especies generalistas y omnívoras como Larus dominicanus. La información está sistematizada en un SIG a partir del cual se generaron mapas temáticos.
Prevalence Of Work Related Musculoskeletal And Psychological Problems Among Female Bus Conductors In Karad.
Authors: Apurva Girish Mehta  , Dr. Smita Chandrakant Patil  , Dr. Chandrakant Babaso Patil  , Dr. Khushboo Trishant Chotai
Published: October 2020

Work related musculoskeletal problems and its impacts are present worldwide and   currently musculoskeletal problem is mostly affected by transportation services mostly buses. In buses, among conductors and bus drivers most affected are the lady conductors. There are about 33% reserved for the female bus conductors job. Due to this reservation, there are many females working in MSRTC (Maharashtra State Road Transport Corporation). They have to work minimum 8-10 hours per day with less period of rest. Therefore, they have to face many musculoskeletal and psychological problems due to their work schedule which begins from early morning to late night. Our objective is to study the prevalence of work related musculoskeletal and psychological problems among female bus conductors in Karad. Study was conducted using a sample size of 48 female bus conductors for a period of 6 months. The inclusion criteria was female bus conductors who were having more than 5 years of working experience and exclusion criteria was the subjects with musculoskeletal problems detected prior to joining their recruited duties and subjects who were not willing to participateWe found that most of the females are suffering from discomfort in lower back 88% followed by head and neck 56%, Psychologically, 60% from mild depression, 44% from stress and 40% from moderate anxiety suffered.  From this study, it can be concluded that these female bus conductors suffer  from  work  related  musculoskeletal  such  as  discomfort  in  major  body  parts  and  psychological  problems  such  as depression, anxiety and stress.
FORMAÇÃO DE PROFESSORES CONTRA O DUALISMO DA PELE DE ONAGRO
Authors: Rossi Rafael
Published: October 2020

O presente texto é instrumento por meio do qual abordamos a importância dos conhecimentos clássicos na constituição da formação de professores. Para atingir este objetivo, partimos da dinâmica entre apropriação e objetivação a partir das contribuições da ontologia lukacsiana. Abordamos o conto “A Pele de Onagro” de Balzac como recurso para demonstrar a tese de que a apropriação dos conhecimentos clássicos numa orientação crítica ontológica é indispensável para uma ampliação e aprofundamento da concepção de mundo e de sociedade dos alunos e não o seu rebaixamento. Isto demanda um esforço teórico e ao mesmo tempo prático. Teórico no sentido de compreender os aspectos formativos dos seres humanos ao longo da dinâmica de reprodução social e, também, no que se refere à identificação das formas mais desenvolvidas do conhecimento. Ao mesmo tempo e indissociavelmente está o desafio prático em concretizar ações educacionais que possibilitem a elevação do nível intelectual dos alunos.
A ARITMÉTICA NA SEÇÃO PARA PEQUENOS MATHEMÁTICOS DA REVISTA O ECHO
Authors: Kuhn Malcus Cassiano , Britto Silvio Luiz Martins , Bayer Arno
Published: October 2020

O tema deste artigo é a Matemática em revista veiculada por colégio jesuíta do Rio Grande do Sul, no século XX. O objetivo é analisar os conhecimentos aritméticos nos problemas recreativos da seção Para Pequenos Mathemáticos da revista O Echo. Como o tema se insere na História da Educação Matemática no estado gaúcho, este estudo qualitativo e documental se ampara na história cultural, para análise da revista editada pelo Colégio Anchieta de Porto Alegre, no século passado. O público-alvo do Echo era a comunidade escolar e a mocidade católica brasileira, pois não havia revistas para os jovens estudantes, com conteúdos religiosos e morais e de formação geral. Nos problemas recreativos analisados, observaram-se conhecimentos aritméticos relacionados com operações fundamentais, critérios de divisibilidade, progressões, permutações e arranjos simples, evidenciando-se o raciocínio lógico e charadas. Os editores buscavam despertar o interesse e a curiosidade da mocidade estudiosa, contribuindo para circulação da revista e formação da juventude católica nos colégios onde a mesma circulava.
TRAJETÓRIAS DE FORMAÇÃO DA JUVENTUDE TRABALHADORA BRASILEIRA: DAS PROMESSAS ÀS INCERTEZAS
Authors: Da Silva José Humberto , Segnini Liliana Rolfsen Petrilli
Published: October 2020

: O presente artigo analisa os investimentos pessoais e financeiros, bem como os arranjos construídos pelos jovens, desde a educação básica ao ensino superior, na perspectiva da garantia do acesso ao emprego e, por conseguinte, uma mudança de posição na estrutura social vigente. O caminho metodológico adotado aglutinou método, técnicas e instrumentos de pesquisa numa abordagem que articula dados quantitativos (acompanhamento das trajetórias in loco) e qualitativos, a partir de diferentes fontes de dados que informam dados educacionais e de emprego no Brasil. Os primeiros investimentos e arranjos realizados, na perspectiva da obtenção deste emprego, foram centrados nos esforços para que esses jovens conseguissem a conclusão do ensino médio, em seguida os cursos de qualificação profissional e, por fim, o acesso ao ensino superior privado. A relação entre trabalho e educação ganha centralidade nas trajetórias pesquisadas. Por meio dos percursos analisados, constatou-se que há um forte discurso em favor da educação como sendo, se não a única, a principal estratégia de mobilidade social ascendente.
Síndrome compartimental abdominal
Authors: Sáez Sáez Ana , De la Fuente Fernández Enrique , Saenz Casco Luis Vicente , Ramos Meca María Asunción
Published: October 2020

El síndrome compartimental abdominal (SCA) se define como la disfunción orgánica causada por la hipertensión intraabdominal (HIA). Ambas son complicaciones frecuentes en pacientes graves ingresados en las unidades de cuidados intensivos (UCI). Las manifestaciones clínicas asociadas suelen ser inespecíficas, por lo que dichas entidades deben ser sospechadas ante pacientes críticos con factores de riesgo. El diagnóstico de la HIA se realiza midiendo de forma indirecta la presión intraabdominal (PIA), generalmente por medio de una sonda vesical. El tratamiento consiste en medidas de soporte, y en algunos casos es necesaria la descompresión abdominal quirúrgica. En esta revisión se presenta la fisiopatología de ambas entidades, así como el enfoque diagnóstico y terapéutico.
El cambio de nombre en el derecho argentino. implicancias registrales y notariales
Authors: Ferrari María Celeste
Published: October 2020

En el presente trabajo se tratarán los nuevos paradigmas legislativos y jurisprudenciales sobre la cuestión del cambio de nombre en Argentina y más específicamente en la provincia de Córdoba, enfocado en el interés del notario para la certera identificación de los sujetos otorgantes de actos jurídicos, contribuyendo a la seguridad de los negocios y evitando fraudes. Se establecerá la normativa vigente, los diferentes supuestos, procedimientos y registros encargados de asentar y emitir la documentación modificada.  Palabras claves: nombre – fe de conocimiento – identidad de género
La importancia de la indización de una revista científica
Authors: A Lozano , R J Saranz
Published: October 2020

Las ciencias, por estos tiempos, han alcanzado un desarrollo logarítmico, con avances científicos que han cambiado el modo de vida de los pueblos en distintas latitudes de nuestro planeta. Las investigaciones, en nuestro caso en el campo de las ciencias biológicas, están al alcance de nuestras manos como nunca ha ocurrido.
“Climate justice” and the Paris climate agreement in the light of greenhouse gas emissions reduction targets
Authors: Todic Dragoljub
Published: October 2020

The aim of the paper is to identify common elements and differences in the
policies of the countries towards the achievement of the Paris Agreement on
Climate (PAC) targets. The introductory part of the paper highlights the
complexity, characteristics and importance of climate change as a global
problem, and suggests the methodological approach. The central part of the
paper is devoted to addressing the theoretical and normative aspects of
?climate justice?. The issue of ?equitable? participation of countries in
the fight against climate change (so-called climate justice) is discussed,
and, above all, the participation of states in reducing greenhouse gas (GHG)
emissions. The relationship of countries to climate change is considered by
assessing their share of global GHG emissions and the climate vulnerability
index, on the one hand, and the targets they have set for reducing GHG
emissions under the PAC, on the other. Countries are grouped into five
groups: countries surrounding the Republic of Serbia (RS), countries whose
emission indicators are similar to those of the RS, countries with the
largest GHG emissions, countries with the smallest GHG emissions, and
countries most vulnerable to climate change. In conclusion, it can be said
that a double discrepancy (the discrepancy between the global target and the
national targets and within the national targets) exists. In addition,
certain common elements in the national targets for reducing GHG emissions
also exist. However, due to the lack of uniformity in the way the GHG
emission reduction targets are indicated, drawing firm conclusions is not
reliable. At the same time, this leaves some room for a more flexible
relationship in defining the national goals of the RS, with reservations
about the obligations associated with the EU membership candidacy.
France and the concept of European sovereignism at the integration crossroad
Authors: Kovacevic Maja , Vukasovic Dejana
Published: October 2020

The article examines the politics of French presidents towards European
integration, with the focus on President Macron's proposals concerning
European sovereignism. The authors apply the Liberal Intergovernmentalism,
which models the EU reforms as a three-stage process in which states first
define preferences, then engage in interstate bargaining, and finally design
common institutions. The main thesis of this article is that France has
relatively stable preferences - augmenting its power through European
integration, which is also translated into Macron's politics, despite
seemingly paradoxical proposals on further delegation of competences to the
EU. France is refusing the status quo in the Union divided on key issues,
and strongly advocate a Europe of concentric circles. The high intensity of
French preferences for the EU reforms is demonstrated through the
alternative coalition?s projects, such as the European Intervention
Initiative or redefinition of its relations with Russia. Contrary to common
interpretations of France as the weaker partner in the Franco-German axis
after the Bing Bang enlargement and Eurozone crisis, the authors' thesis is
that France is regaining a stronger role at the integration crossroad. In
the context of the uncertain future of the transatlantic partnership,
China's rise and the threat of further EU marginalization in contemporary
international relations, France is determined to have the ?balancing power?
status on the global stage. Based on its military and diplomatic power, as
well as large geographic influence, France is offering a strong alliance to
Germany, which has no serious alternative. The authors conclude that this
alliance would provide an opportunity for both countries to further project
their power, and create a new context for inevitable re-opening of the
?German question?.
“Mini-Schengen” as an opportunity for new regional economic integration
Authors: Rapaic Stevan
Published: October 2020

The paper analyses the idea of ?Mini-Schengen? as a new opportunity for
resolving disputes between the countries of the Western Balkans and as
economic and political integration. The main advantages of membership in
?Mini-Schengen? are the removal of customs and all other barriers in
intraregional trade, which would enable domestic companies to place their
products throughout the region with the lowest possible logistic costs while
maximizing protection for their products and market access opportunities.
Doubts about what exactly ?Mini-Schengen? should assume and which countries
of the Western Balkans would be members of this union are still numerous. In
this paper, the author provided answers to some main issues about this
possible integration. The paper analyses the macroeconomic situation in
Albania, North Macedonia, and Serbia, anticipating which countries would
achieve the greatest benefit for their economy in the case of the
establishment of ?Mini-Schengen?. Political consequences of the
?Mini-Schengen? are also analysed to provide an answer to which countries
would achieve the greatest political benefit from this association, and
which would suffer certain political damage. The author concludes that the
main conception of ?Mini-Schengen? is to create a single labour market,
which would maintain a low minimum wage in Serbia and ensure stability in
the influx of labour in order to keep the existing foreign investors and
attract new ones.
Negation and asymmetry: What is left of negative utilitarism
Authors: Krstic Predrag
Published: October 2020

The beginning of the paper is dedicated to Popper?s general understanding of
the scientific method, in which the moment of refutation stands out. The
second part of the paper presents the application of that model to the field
of ethics and ?public policy,? in the form of a suggestion to be called
later ?negative utilitarianism.?. Then, attention is focused on the
objections addressed to negative utilitarianism, primarily when it comes to
the ?repugnantconclusion? that brings it closer to promortalism and
anti-natalism. In the final part, the author strives to defend what remains
of the intuition that motivates negative utilitarianism by its reduction to
a principle, and not to a complete theory or a comprehensive conception.
Reality, fundamentality, grounding (and cognate notions)
Authors: Popovic Sasa
Published: October 2020

The notion of grounding is one of the central notions in the debates
concerning ontological dependence in contemporary metaphysics and
metametaphysics. In this paper we have carried out a comparative analysis of
grounding, supervenience, reality, fundamentality, and cognate notions, and
we have demonstrated what their role should be in the context of
neo-Aristotelian hierarchical ontologies and the project of metaphysical
foundationalism. We have also sketched out some basic outlines of what Kit
Fine calls ?the pure logic of ground? by establishing certain formal
desiderata which grounding ought to meet in order to successfully carry out
its specific ontologico- explanatory role. It is finally shown that grounding
suffers from similar problems and shortcomings as supervenience, and that a
satisfactory solution of those problems cannot be found by looking to
metaphysical primitivism according to which grounding is a sui generis,
primitive and unanalysable notion which is nonetheless essential for
metaphysics. Even though grounding might turn out to be an ?essentially
contested concept?, in the end we suggest how the aforementioned problems
might be met by means of holistic considerations of grounding within the
broader context of the entire (meta)metaphysical theory.
The relation between the beauty and the sublime in Hartmann′s aesthetics
Authors: Grubor Nebojsa
Published: October 2020

The text examines the relationship between the beauty and the sublime in
Hartmann?s aesthetics. According to the basic assumption of Hartmann?s
aesthetics, the sublime, like all other aesthetic values, are subordinated
to the beauty. The text shows that the relationship between the beauty and
the sublime in Hartmann?s aesthetics is complex and that beauty formally
includes the sublime, but that the sublime in terms of fixing aesthetic
content is the core of aesthetic issues.
Optimization and CFD analysis of a shell-and-tube heat exchanger with a multi segmental baffle
Authors: Aydin Ahmet , Yaşsar Halit , Engin Tahsin , Buyukkaya Ekrem
Published: October 2020

The shell-and-tube type heat exchangers have long been widely used in many fields of industry. These types of heat exchangers are generally easy to design, manufacturing, and maintenance, but require relatively large spaces to install. Therefore, the optimization of such heat exchangers from thermal and economical points of view is of particular interest. In this article, an optimization procedure based on the minimum total cost (initial investment plus operational costs) has been applied. Then the flow analysis of the optimized heat exchanger has been carried out to reveal possible flow field and temperature distribution inside the equipment using CFD. The experimental results were compared with CFD analyses results. It has been concluded that the baffles play an important role in the development of the shell side flow field. This prompted us to investigate new baffle geometries without compromising from the overall thermal performance. It has been found that the heat exchanger with the new baffle design gives rise to considerably lower pressure drops in the shell side, which in turn reducing operating cost. The new baffle design is particularly well suited for shell-and-tube heat exchangers, where a viscous fluid-flows through shell side with/out phase change.
Thermodynamic performance analysis of supercritical CO2 Brayton cycle
Authors: Yang Xiaoping , Cai Zhuodi
Published: October 2020

The supercritical CO2 is used as working fluid for power system cycle. This paper presents thermodynamic performance analysis results on supercritical CO2 Brayton cycle. Based on the assumptions of the relevant initial parameters, the mathematical models of compressor, turbine, recuperator and heater are constructed, and the thermal efficiency of regenerative Brayton cycle and recompression Brayton cycle are calculated and analyzed. The results reveal that the efficiency of the recompression cycle is higher than that of the simple regenerative cycle. The effects of inlet temperature, inlet pressure of the main compressor and inlet temperature, inlet pressure of the turbine on the thermodynamic performance of the recompression cycle are studied, and the influencing mechanism is explained. The results show that the cycle efficiency decreases with the increase of the inlet temperature of the main compressor. There exists an optimum inlet pressure in the main compressor to maximize the cycle efficiency. The cycle efficiency of the system increases with the increase of the inlet temperature and pressure of the turbine. When the inlet temperature of the turbine exceeds 600?, the thermal efficiency of the cycle can reach more than 50%.
Classification of retrofit measures for residential buildings according to the global cost
Authors: Stojiljkovic Mirko , Vuckovic Goran , Ignjatovic Marko
Published: October 2020

Data-driven black-box surrogate models are widely used in research related to buildings energy efficiency. They are based on machine learning techniques, learn from available data, and act as a replacement for or an addition to complex and computationally intensive knowledge-based models. Surrogate models can predict energy demand, indoor air temperature, or occupants behavior, explore search space in optimization problems, learn control rules, etc. This paper analyzes surrogate models that classify building retrofit measures directly according to the global cost. In addition, they quantify the importance of each variable for the classification process. The models are based on random forest classifiers, which are fast and powerful ensemble learners. They can be applied to effectively reduce search spaces when optimizing energy renovation measures or to rapidly identify projects that deserve financial support. This approach is applied to two residential buildings and three scenarios of price development. The training process uses a small share of retrofit options assessed with standard calculations of the heating and cooling demands, as well as the global cost. The results show very high classification performance, even when the models are trained with small and imbalanced training sets. The obtained recall, precision, and F-score values are mostly above 95%, except for extremely small training sets.
In vivo reporter assays uncover changes in enhancer activity caused by type 2 diabetes associated SNPs
Authors: Admin Ada , Eufrásio Ana , Perrod Chiara , Duque Marta , J.Ferreira Fábio , Galhardo Mafalda , Bessa José
Published: October 2020

Many single nucleotide polymorphisms
(SNPs) associated to type 2 diabetes overlap with putative endocrine
pancreatic enhancers, suggesting that these SNPs modulate enhancer activity and
consequently, gene expression. We performed in vivo
mosaic transgenesis assays in zebrafish to quantitatively test the
enhancer activity of type 2 diabetes-associated loci. Six out of ten tested sequences are endocrine pancreatic
enhancers. The risk variant of two sequences decreased enhancer activity, while
in another two incremented it. One of the latter (rs13266634) locates in a SLC30A8
exon, encoding a tryptophan-to-arginine substitution that decreases SLC30A8
function, being the canonical explanation for type 2 diabetes risk association.
However, other type 2 diabetes associated SNPs that truncate SLC30A8, confer
protection to this disease, contradicting this explanation. Here, we clarify
this incongruence showing that rs13266634 boosts the activity of an overlapping
enhancer, suggesting a SLC30A8 gain-of-function as the cause for the increased
risk for the disease. We further dissected the functionality of this enhancer
finding a single nucleotide mutation sufficient to impair its activity.
Overall, this work assesses in vivo the importance of disease-associated
SNPs in the activity of endocrine pancreatic enhancers, including a poorly
explored case where a coding SNP modulates the activity of an enhancer.
”Hårt arbete har gjort mig till den jag är”– pengar och moraliskt värde som pedagogiska aspekter i två Kalle Anka-album
Authors: Wallner Lars
Published: October 2020

Kalle Anka & Co har hyllats för sitt berättande och sina karaktärer, samtidigt som serien kritiserats för att vara förmedlare av kulturimperialism. Denna artikel diskuterar två seriealbum skapade för användning i svensk grundskola, sammansättningar av tidigare publicerade serier. Då dessa samlingar är tänkta att användas i skola så kan samlingarna också förväntas gestalta värderingar i linje med detta. Som centrum för handlingen, eller för karaktärsmotivation, är pengar den enskilt mest förekommande faktorn i dessa berättelser. Nio berättelser har valts ut och analyseras utifrån 1) hur fattiga och rika karaktärer porträtteras genom bild och text och 2) hur pengar och materialism konstrueras som moraliska värden. Analysen visar hur värden om materialism och pengar representeras av olika karaktärer: Joakim von Anka (rikedom, snålhet), Kalle Anka (lättja, slösaktighet) och Knattarna (godhet, arbetsiver). Som representanter för barnläsaren skildras Knattarna som goda arbetare, där arbetet är sin egen belöning och essentiellt för god karaktär. Dock kan rikedom som kommer från hårt arbete (till exempel Joakims) associeras med omoral om inte pengarna används till goda syften. Vidare gestaltas vissa karaktärer som intrinsikalt fattiga, vilket kan ses som problematiskt om det inte diskuteras tillsammans med unga läsare. Här kan läraren vara avgörande för elevers möjlighet till texttolkning.
English abstract
“Hard work made me who I am”– money and moral value as pedagogical aspects of two Donald Duck albums.
Donald Duck & Co have been simultaneously celebrated for vivid stories and characters, and criticized as being conveyors of cultural imperialism. This article discusses two comic albums collecting previously published comics for use in Swedish elementary school. As these collections are designed for schools, they can be expected to impart certain school values. As plot device, or as basis for character motivation, money is the single most common factor in a majority of the stories. Therefore, nine stories have been analysed, focusing primarily on 1) character portrayal through image and text, and 2) how money and materialism are constructed as moral values. The analysis shows how values of materialism and money are displayed differently, represented by different characters: Scrooge McDuck (wealth, greed), Donald Duck (sloth, wastefulness), and Huey, Dewey and Louie (goodness, hard-working). As representatives of the child reader, the nephews show a love of hard work essential to good moral character. However, wealth that comes from hard work (Scrooge’s wealth) could also be immoral if it is not spent properly (or at all). Moreover, certain characters are constructed as intrinsically poor and hopeless, which is problematic. Here, the teacher could be vital for students’ possibilities of interpreting the texts.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS LECTORA INSPIRE PADA MATERI LAPORAN HARGA POKOK
Authors: Rahmawati Nurvia Dwi , Susilowibowo Joni
Published: October 2020

Abstrak: Penelitian pengembangan ini mempunyai tujuan untuk menghasilkan produk, menganalisis kelayakan serta respon peserta didik terhadap media pembelajaran interaktif berbasis lectora inspire pada materi laporan harga pokok di SMK Negeri 2 Tuban. Jenis penelitian ini ialah penelitian pengembangan dengan menggunakan model pengembangan ADDIE yang dimodifikasi oleh Branch. Penelitian ini menggunakan data kualitatif dan kuantitatif dengan instrumen pengumpulan data berupa angket terbuka dan angket tertutup. Teknis analisis data yang digunakan berupa analisis deskriptif yang berkaitan dengan aspek efektivitas melalui angket. Media pembelajaran interaktif ini divalidasi oleh dua ahli materi dan satu ahli media, serta diiujicobakan kepada 20 peserta didik kelas XII Akuntansi SMK Negeri 2 Tuban. Hasil akhir validasi ahli materi sejumlah 89,13% dengan kategori “sangat layak”, validasi ahli media sejumlah 84,89% dengan kategori “sangat layak”, serta mendapat skor dari respon peserta didik sejumlah 94,22% dengan kategori “sangat memahami”. Sehingga dapat dinyatakan jika media pembelajaran ini sangat layak dipergunakan pada proses pembelajaran.Kata Kunci: media pembelajaran interaktif, lectora inspire, laporan harga pokok Abstract: This development research has the purpose to produce products, analyze the feasibility and response of students to interactive learning media based on Lectora inspire on the subject matter cost price report at SMK Negeri 2 Tuban. This type of research is development research using the ADDIE development model modified by Branch. This study uses qualitative and quantitative data with data collection instruments in the form of open questionnaires and closed questionnaires. Technical analysis of the data used in the form of descriptive analysis related to the aspect of effectiveness through the questionnaire. This interactive learning media was validated by two material experts and one media expert, and was trialled to 20 students of class XII Accounting of SMK Negeri 2 Tuban. The final result of material expert validation was 89,13% with the category "very worthy", the validation of media experts was 84.89% with the category "very worthy", and received a score of 94.22% in the responses of students in the "very understanding" category. So, it can be stated if the interactive learning media is very decent when used in the learning process.Keywords: interactive learning media, lectora inspire, cost price report
Islam and Counseling: Model of Practice in Matrilineal System of The Minangkabau Culture
Authors: Yusri Fadhilla , Afrida Yeni
Published: October 2020

Islam and counseling are related to each other in their application. Islam determines counseling as a way to help one another between human beings. Counseling utilizes Islam as an approach to counseling services. Counseling is an unfamiliar thing to Minangkabau as one of the matrilineal communities. The philosophy of matrilineal community in Minangkabau is adat basandi syara’, syara’ basandi kitabiullah. This philosophy is based on the majority of Minangkabau as Moslem. The combination of Islam with counseling can be a gateway to counseling as a part of the matrilineal community in Minangkabau. Islam dan konseling saling terkait dalam penerapannya. Islam mengartikan konseling sebagai cara untuk saling membantu antar sesama manusia. Konseling memanfaatkan Islam sebagai pendekatan layanan konseling. Penyuluhan merupakan hal yang asing bagi Minangkabau sebagai salah satu komunitas matrilineal. Filosofi masyarakat matrilineal di Minangkabau adalah adat basandi syara ', syara' basandi kitabiullah. Filosofi ini didasarkan pada mayoritas Minangkabau sebagai Muslim. Perpaduan Islam dengan konseling dapat menjadi pintu gerbang konseling sebagai bagian dari komunitas matrilineal di Minangkabau
A fenomenologia materialista de Alain Badiou: um programa de pesquisa para as Ciências da Religião | The materialist phenomenology of Alain Badiou: a research program for Religious Studies
Authors: Zabatiero Júlio Paulo Tavares Mantovani
Published: October 2020

A fenomenologia clássica da religião continua sendo um tema importante de debate na pesquisa sobre religiões no Brasil. A sua contribuição é reconhecida, mas os seus limites epistêmicos e epistemológicos são destacados sem, porém, que se ofereça um caminho alternativo para a sua renovação. Neste ensaio serão apresentados os aspectos principais da fenomenologia materialista de Alain Badiou, descrita no segundo volume de sua trilogia “Ser e Evento”, como uma alternativa metodológica e epistemológica viável a uma nova fenomenologia da religião. A obra de Badiou é extensa e internacionalmente reconhecida, mas pouco utilizada no Brasil, especialmente no campo das ciências das religiões. A sua apresentação visa, portanto, dar continuidade ao debate metodológico e epistemológico desse campo de pesquisa. O artigo tem início com uma breve discussão a respeito das críticas recentes à fenomenologia clássica da religião, seguida pela apresentação da fenomenologia materialista de Badiou (também nomeada de fenomenologia calculada ou fenomenologia objetiva), encerrando com uma aplicação concreta dessa fenomenologia ao tema da relação entre religião e esfera pública.
A CRITICAL DISCOURSE ANALYSIS OF AN ESSAY: EMPLOYING RUTH WODAK’S MODEL
Authors: Ali Ameer , Soomro Mohammad Ibrahim
Published: October 2020

Critical Discourse Analysis demystifies power mechanisms operating in different kinds of discourse. It sets forth hidden discourses and meanings for common people. Besides, the current research assignment has studied Bernard Lewis’ essay: The Roots of Muslim Rage using Ruth Wodak’s Discourse Historical Model (2004). Moreover, the researchers have employed purposive sampling as a research design to collect the data. The research is qualitative as it answers the research questions using Wodak’s model. The purpose of this research was to expose hermeneutic interpretations of orientalist discourse that reflect implausible thinking about Muslims. However, much work has been done on discourse of orientalism, yet from Wodak’s point of view much work is to be done; hence, the current research paper has also contributed to the field of critical discourse analysis. The subjectification of the Muslims through oriental norms is the main theme in Lewis’ essay as revealed by analysing lexical and syntactic units. Thus, the current research has concluded the findings in accordance with the research questions and research objectives.