bluuebunny/crossref_metadata_2025 huggingface dataset:
USO DE BLOCKCHAIN NA ADMINISTRAÇÃO PÚBLICA: probidade, transparência e eficiência
Authors: Gonçalves da Silva Lucas , Ribeiro Cardoso Henrique , Aragão Costa Camilla Ellen
Published: December 2024

O presente trabalho se propõe a investigar se a utilização da tecnologia blockchain pode tornar a Administração Pública mais transparente, eficiente e proba. Para alcançar esse intento, busca-se, de forma específica, realizar um breve retrospecto em relação à procura por uma administração pública mais transparente e eficiente; destacar como as tecnologias de informação e comunicação têm impactado a Administração Pública; conceituar a blockchain e detalhar suas dinâmicas; e, por fim, avaliar se as dinâmicas da blockchain podem tornar a Administração Pública mais transparente, eficiente e proba. Quanto à metodologia, o método utilizado é o hipotético-dedutivo, com instrumentos bibliográficos e documentais, em uma pesquisa de natureza exploratória e qualitativa, fundamentada em uma abordagem temática histórico-evolutiva e dogmática. O trabalho lida com as seguintes hipóteses: a demonstração dos problemas da Administração Pública servirá para expor quais desafios devem ser enfrentados; o estudo da introdução de tecnologias no âmbito da Administração Pública ajudará a compreender as tendências atuais da administração; a compreensão da blockchain permitirá descrever como a aplicação dessa tecnologia pode ocorrer na Administração Pública; o entendimento da blockchain fornecerá insights sobre como a certificação digital das transações pode promover uma Administração Pública mais afinada com os seus propósitos.
CYBERVIGILÂNCIA, DADOS E VIOLAÇÕES DE DIREITOS HUMANOS
Authors: Cardoso Squeff Tatiana , Bolzan de Morais Jose Luis
Published: December 2024

A cibernetização da vida tem permitido que atos diários ordinários sejam mapeados, coletados, analisados e armazenados em ambiente digital. Diante desse quadro, tem-se que os dados pessoais transformaram-se em verdadeiros ativos na sociedade em rede hodierna, os quais, caso não sejam devidamente manipulados pelo Estado, podem ensejar a violação de direitos humanos. Em vista disso, essa investigação busca expor essa nova cyberrealidade e a importância dos dados, debatendo-se, em seguida, a/o coleta/processamento/uso incorreto de dados pessoais pelo Estado, questionando a existência de requisitos a serem seguidos pelas autoridades nacionais ao fazê-la/o. Para tanto, desde um estudo dedutivo, realiza-se um estudo de caso, explorando-se a recente decisão da Corte Europeia de Direitos Humanos no caso The Big Brother Watch et al. vs. Reino. Ademais, frisa-se que os objetivos serão analisados desde os métodos descritivo, explicativo e analítico, sendo desenvolvidos também desde as técnicas bibliográfica e documental de pesquisa, selecionadas qualitativamente desde as palavras-chave deste texto.
Desenvolvimento, validação e confiabilidade de uma escala de dor aguda pós-operatória em asininos (equus asinus)
Authors:   , Oliveira Maria Gláucia Carlos de
Published: December 2024

Este estudo teve como objetivo identificar os comportamentos de jumentos indicativos de dor aguda e a partir desses comportamentos refinar e validar uma escala para avaliar dor aguda nesses animais. Quarenta e quatro jumentos adultos foram submetidos à castração após sedação com xilazina endovenosa (IV), indução com éter gliceril-guaiacol e tiopental IV, bloqueio anestésico local e manutenção com isoflurano. Os animais foram monitorados por vídeos que foram assistidos para registro de toda linguagem corporal expressada pelos jumentos. A escala foi construída a partir desses vídeos, associado a comportamentos álgicos descritos para equinos, seguido de validação de conteúdo. A escala foi avaliada por três avaliadores cegos e um observador padrão-ouro, por meio de vídeos editados referentes ao pré-operatório e pós-operatório, que compreendeu: três a quatro horas após a recuperação anestésica, entre 5 e 6 horas após a recuperação anestésica (2 horas após o resgate analgésico com flunixin - 1,1 mg / kg, dipirona - 10 mg / kg e morfina - 0,2 mg / kg IV) e 24 horas após a cirurgia. A validade de conteúdo, sensibilidade, especificidade e a capacidade de resposta dos comportamentos foram utilizados para refinar a escala. A confiabilidade intra e interobservador foi determinada pelo coeficiente Kappa ponderado, validade de critério pela comparação da escala proposta com a escala visual analógica (VAS), consistência interna pelo coeficiente α de Cronbach, correlação item-total pelo coeficiente de Spearman e escore de resgate analgésico pelas características operacionais do receptor curva e índice de Youden. O principal comportamento relacionado a dor nos jumentos foi a elevação do membro pélvico. A escala apresentou confiabilidade intraobservador muito boa (0,88 - 0,96), confiabilidade interobservador variou de boa a moderada (0,56 - 0,66), mostrou responsividade para todos os itens, boa validade de critério. EVA (0,75), consistência interna aceitável (0,64), e exceto pela posição do pescoço e direção da cabeça, correlação item-total adequada e de acordo com a análise de componentes principais, boa associação entre os itens. A precisão do ponto de resgate analgésico foi excelente (área sob a curva = 0,91). O escore de resgate analgésico foi ≥ 3 de 11 pontos. A UFERSA-Unesp pode diagnosticar e quantificar a dor aguda em jumentos submetidos à castração, pois o instrumento é confiável e válido, com um escore analgésico de intervenção definido
Ecologia de pequenos mamíferos (Didelphimorphia e Rodentia) em uma área de Caatinga do Rio Grande do Norte
Authors:   , Pereira Viviane Morlanes
Published: December 2024

Os pequenos mamíferos (Didelphimorphia e Rodentia) formam o grupo ecológico mais
diversificado de mamíferos do Brasil e, sua abundância, distribuição e diversidade estão
diretamente relacionadas com variações espaço-temporais no clima e na disponibilidade de
recursos. A Caatinga é um ecossistema semiárido neotropical exclusivamente brasileiro,
caracterizado por altas temperaturas e um regime sazonal e irregular de chuvas. No entanto há
pouca informação sobre o efeito que o déficit hídrico e a sazonalidade na disponibilidade de
recursos têm sobre a composição, estrutura e dinâmica das comunidades de pequenos
mamíferos neste bioma. O presente estudo se divide em dois capítulos: o primeiro capítulo,
apresenta dados sobre as densidades populacionais; e os padrões temporais em relação com a
sazonalidade. E o segundo capítulo apresenta dados aparentes de sobrevivência e
recrutamento para Gracilinanus agilis; e avaliou se eles diferem entre sexo e estado
reprodutivo, e se eles são dependentes do efeito da chuva. Para o estudo foi utilizado o
método de captura-marcação-recaptura através do uso de 115 armadilhas em vivo (modelos
Sherman e Tomahawk), colocadas no solo e no sub-bosque, ao longo de cinco anos e nove
meses sucessivos entre junho de 2014 a fevereiro de 2020. A área de estudo localiza-se em
um fragmento de 8,25 ha de mata nativa de Caatinga, situada na Estação Experimental da
Universidade Federal Rural do Semi-Árido, Mossoró-RN
Produtividade e teor de óleo de cultivares de girassol sob fertirrigação nitrogenada em duas safras agrícolas
Authors:   , Souza Almir Rogerio Evangelista de
Published: December 2024

O girassol (Helianthus annuus L.) por sua ampla adaptação e utilização tem emergido no
cenário mundial com significativo potencial econômico, principalmente na produção de
aquênios e óleo. A expansão de áreas cultivadas com girassol em diversos países em
condições semiárido tem exigido práticas adequadas de manejo de fertilização, assegurando
produtividades e rentabilidades satisfatórias. As adubações nitrogenadas associadas à
cultivares mais produtivas têm sido relatados com atenção especial, uma vez que, esses são
componentes indispensáveis no sucesso do investimento. Neste sentido, foram conduzidos
experimentos em duas safras agrícolas em fevereiro/maio de 2016 e 2017, para avaliar a
produtividade de aquênios e óleo e a responsividade econômica de cultivares de girassol
fertirrigadas com doses de nitrogênio no semiárido nordestino, Mossoró-RN. As parcelas
foram constituídas por cinco doses (0, 30, 60, 90, 120 kg ha-1) de adubação nitrogenada e nas
subparcelas quatro cultivares de girassol (Aguará 06, Altis 99, Multissol e BRS 122). As
doses de nitrogênio influenciaram positivamente o número, massa, produtividade de aquênios
e óleo, com exceção para o teor de óleo das cultivares de girassol, nas duas safras agrícolas. A
dose de N para a máxima produtividade de aquênios, para a Multissol e BRS 122 foi de 81,8 e
86,6 kg ha-1 e para Altis 99 e Aguará 06 na dose de 120 kg ha-1 de N, respectivamente, na
safra agrícola de 2016. Em 2017, a Multissol e BRS 122 na dose de 100,7 e 92,8 kg ha-1 e
para a Altis 99 e a Aguará 06, com 120 kg ha-1 de N. A dose de máxima eficiência econômica
de N é de 60 e 70 kg ha-1, para as cultivares Multissol e BRS 122. Para a produtividade de
óleo, as doses máximas de 78,0 e 86,7 kg ha-1 de N, para as cultivares BRS 122 e Aguará 06, a
Multissol e Altis 99 na dose de 120 kg ha-1 de N, na safra de 2016. Em 2017 a BRS 122 e
Multissol obtiveram na dose de 88,6 e 99,1 kg ha-1 de N, e a Altis 99 e a Aguará 06 com 120
kg ha-1. A cultivar Aguará 06, obteve maior produtividade de aquênios e rendimento de óleo
nas duas safras agrícolas. A margem líquida correspondeu ao aumento das doses de
nitrogênio, atingindo uma margem líquida máxima de R$ 366,89 ha-1 na dose de 81 kg ha-1 de
N para a ‘BRS122’; para a ‘Multissol’ foi de R$ 577,41 ha-1 com 118 kg ha-1 de N. Para a
‘Aguará 06’ (R$ 2.124,00 ha-1) e ‘Altis 99’ (R$ 976,66 ha-1) na dose de 120 kg ha-1 de N, na
safra de 2016. Na safra de 2017, a ‘BRS 122’obteve R$ 190,90 ha-1 na dose de 83,0 kg ha-1 de
N e a ‘Multissol’ alcançou R$ 657,50 na dose de 85,0 kg ha-1 de N; as cultivares ‘Aguará 06’
(R$ 1.078,00 ha-1) e ‘Altis 99’ (R$ 957,14 ha-1) na dose de 120 kg ha-1 de N. A taxa de
retorno e o índice de lucratividade foram positivos para todas as cultivares nas safras
agrícolas
Produção e qualidade da batata doce em respostas a doses de nitrogênio e potássio e lâminas de irrigação
Authors:   , Sarmento Diogenes Henrique Abrantes
Published: December 2024

A batata doce vem sendo destacada como alimento saudável, sendo indicada em dietas

de baixas calorias na alimentação humana sem restrições. Ela é cultivada em todas as

regiões brasileiras, com maior presença na região Nordeste e Sudeste. O nitrogênio e o

potássio são os dois macronutrientes mais importantes, que tem como função,

armazenar energia na fotossíntese e respiração, assim como, energia para reações de

síntese de proteínas e fixação biológica de nitrogênio. Devido à restrição de água para

uso nos perímetros irrigados e a procura de novas culturas que requer lâminas de

irrigação menores e tenham valores de comercialização compatíveis estudou-se o

comportamento da cultura da batata doce em um Neossolo Quartzarênico submetida a

diferentes lâminas de irrigação, determinada em relação a ETc estimada (L1: 452 mm

(60% da ETc), L2: 568 mm (80% da ETc), L3: 684mm (100% ETc) e L4: 801 mm

(120% da ETc)), até 138 dias após o plantio, sendo destes 104 mm para todos os

tratamentos nos primeiros 15 dias e entre os 121 e 165 dias, choveu 392 mm. Em cada

Lâmina de irrigação estudou-se doses de N ou K utilizando o delineamento em blocos

casualizados com quatro repetições. As doses de Nitrogênio (N) foram: N1 - 10, N2 -

40, N3 - 75, N4 -110 e N5 -150 kg ha-1 e as de Potássio (K): K1 - 0; K2 - 50; K3 - 100;

K4 - 150 e K5 - 200 kg ha-1 de K2O). Os Nutrientes foram aplicados em fertirrigação. A

fonte de N foi o nitrato de cálcio e de K foi o cloreto de potássio, aplicados a partir do

vigésimo dia após o plantio (DAP) para todos os tratamentos, como fonte de fósforo

aplicou o MAP. As variáveis analisadas foram: produtividade total e comercial, numero

de tubérculos, massa média de tubérculos, e de qualidade (Firmeza, Sólidos Solúveis e

Amido). Recomenda-se a aplicação da lâmina L1, 60% da ETc estimada para a cultura

da batata doce, e dose de 40 kg ha-1 de Nitrogênio. A qualidade da batata não foi

alterada com as doses de N e lâminas de irrigação. O teor de amido teve aumento em

resposta a dose de N dependente da lâmina de irrigação aplicada. Houve resposta

positiva de produção ao aumento da dose de K
Influence of the retropreparation ultrasonic insert type on the adhesive union of fiberglass posts within the root canal
Authors: Gabriella Gulden Lobo  , Gabriela Carvalho da Rosa  , Marcelo Munhoz  , Francisco Montagner  , Vicente Castelo Branco Leitune  , Tiago André Fontoura de Melo
Published: December 2024

To assess the displacement resistance of cemented fiberglass posts within the root canal, based on the type of ultrasonic retropreparation insert used during endodontic surgery. Material and methods: Thirty primary bovine incisor roots, measuring 17 mm in length, underwent endodontic treatment. After a seven-day period, the teeth were debrided and prepared to receive 13 mm posts. The roots were randomly divided into three groups, depending on the type of ultrasonic retropreparation insert used: GC – no retropreparation (control); GL – smooth insert; GD – diamond insert. The posts were cemented using RelyX U200® within the root canal. Subsequently, the roots were immersed in distilled water for 15 days and then sectioned to create specimens with an average thickness of 1.87 mm in each of the root thirds (cervical and middle). These specimens were subjected to a push-out test. Following the test, the fractured samples were examined under a stereomicroscope to determine the fracture pattern. The data obtained were analyzed using a one-way Anova test and non-parametric t-test (α = 0.05). Results: There were no statistically significant differences in the cervical third when comparing the tested ultrasonic inserts. However, in the analysis of the middle third, the use of a smooth ultrasonic insert had a significant impact on the adhesion of the intraradicular post (P < 0.05). Conclusion: The application of a smooth ultrasonic insert during endodontic retropreparation significantly influenced the displacement resistance of intraradicular fiberglass posts cemented in the middle third of the canal. In the cervical third, the type of ultrasonic retropreparation insert used did not affect post retention.
Perfil do comportamento de saúde de pacientes infantis durante a pandemia de covid-19
Authors: Priscila Kulek Sampaio  , Mariana Perotta  , Cristiano Miranda de Araújo  , Thalita de Paris Matos  , Bianca Lopes Cavalcante Leão  , Michelle Nascimento Meger
Published: December 2024

Determinar o perfil de comportamento de saúde, ante a pandemia de covid-19, das famílias de um grupo de crianças atendidas na clínica odontológica de uma universidade privada. Material e métodos: Estudo prospectivo, transversal, de caráter quantitativo exploratório, realizado com os pais ou responsáveis pelas crianças que procuraram atendimento na clínica odontológica de uma universidade, no primeiro semestre de 2022. A coleta de dados envolveu um questionário que constou dos dados de identificação do responsável e da criança, questões sobre impacto da pandemia em hábitos alimentares, alterações da rotina, postura em relação a consultas, hábitos de saúde bucal e vacinação contra covid-19 das crianças. Resultados: A amostra contou com 33 crianças com idade entre 4 e 12 anos, sendo a maioria (54,5%) do sexo masculino. Quanto à saúde bucal, a maioria das crianças não teve dor de dente (75,8%), não relatou lesões de cárie (57,6%), não teve traumatismo dentário (84,8%) e conseguiu manter os hábitos de higiene bucal (78,8%). Em 78,8% das famílias houve alguém que se contaminou com o coronavírus, visto que 39,3% das crianças foram contaminadas e, destas, 23,1% foram assintomáticas. Considerando a vacinação contra a covid-19, 69,7% das crianças foram vacinadas mesmo 60% dos pais afirmando não se sentirem seguros. Conclusão: A amostra caracterizou-se em sua maioria por famílias que conseguiram manter a saúde bucal das crianças, vivenciaram a contaminação pelo coronavírus e vacinaram as crianças.
Prevalência dos erros radiográficos durante o tratamento endodôntico realizados por alunos da Universidade do Sul de Santa Catarina
Authors: Fernando Guimarães Godinho  , Daniela Peressoni Vieira Schuldt  , Lincon Hideo Nomura  , Daniela de Rossi Figueiredo  , Josiane de Almeida  , Beatriz Serrato Coelho
Published: December 2024

A Endodontia é uma das áreas odontológicas que mais necessitam de radiografias transoperatórias. Alguns dos itens usados durante o tratamento podem dificultar a realização de uma radiografia de qualidade, podendo acarretar um tratamento inadequado e prognóstico desfavorável. Objetivo: Determinar a prevalência de erros em radiografias periapicais durante o tratamento endodôntico realizados por acadêmicos de Odontologia da Universidade do Sul de Santa Catarina – Campus Pedra Branca. Material e métodos: Foram avaliadas 2.211 radiografias periapicais digitais de 226 prontuários de pacientes que realizaram tratamento endodôntico no segundo semestre de 2017 e durante os anos de 2018 e 2019. Analisaram-se os seguintes erros radiográficos: posicionamento incorreto do filme, angulação vertical, angulação horizontal, aparecimento de meia-lua ou halo, corte de estrutura dental, erro de dissociação e erro no uso de posicionador. Registraram-se a região e o dente tratado, a etapa do tratamento em que a radiografia foi realizada e a fase do aluno. Os dados foram tabulados, as variáveis qualitativas apresentadas por meio de percentuais e os testes de associação foram feitos mediante o Qui-quadrado de Pearson, com valor de p ≤0,05. Resultados: Das radiografias analisadas, 64,7% (1431) foram consideradas inadequadas, ou seja, possuíam pelo menos um erro radiográfico; o erro mais prevalente foi angulação vertical incorreta, com 41,9% (600). Conclusão: Realizar radiografias periapicais durante os tratamentos endodônticos é um procedimento relativamente difícil, por isso necessita de reforço constante das técnicas e maior treinamento dos acadêmicos, haja vista mais da metade da amostra apresentar erros radiográficos.
Multiple diastemas closure with minimally invasive veneers: a 12-month follow-up
Authors: Sérgio Kiyoshi Ishikiriama  , Karin Cristina da Silva Modena  , Rafael Massunari Maenosono  , Bella Luna Colombini Ishikiriama  , Adilson Yoshio Furuse  , Constantino Fernandes Neto
Published: December 2024

Multiple diastemas commonly cause esthetical complaints, especially in high demanding patients that frequently have sound teeth. Objective: The aim of the present clinical report is to describe the treatment of multiple diastemas with surgical crown lengthening and minimally invasive lithium disilicate veneers. Case report: During clinical evaluation, it was observed multiple well distributed diastemas in anterior superior teeth and a reduced length of the central incisors. Initially, crown lengthening surgery was performed to restore adequate width-to-length ratio to central incisors. After healing, impressions were taken, and study cast models revealed the need for slight reduction of proximal surfaces to remove retentive areas and provide good adaptation for laminate veneers. After a conservative preparation, impressions were taken with addition silicone and cast models were sent to a laboratory. Lithium disilicate laminate veneers were fabricated by the heat press technique. Cementation protocol was performed with light-activated resin-cement, which was carefully chosen in terms of color and fluorescence. Conclusion: Multiple diastemas can be successfully treated with minimal restorative interventions involving little or no preparation; however, a careful evaluation must be conducted in order to remove retentive areas. Furthermore, teeth width-length ratio must also be considered when planning such esthetic restorations.
Remoção de dente impulsionado para o seio maxilar durante a exodontia: relato de caso
Authors: Letícia Thais Otaviano  , Gabriela Bohneberger  , Érica Sabrina Zuppa  , Eleonor Álvaro Garbin Júnior  , Natasha Magro Érnica  , Geraldo Luiz Griza  , Ricardo Augusto Conci
Published: December 2024

O seio maxilar caracteriza-se por um espaço pneumatizado localizado no terço médio da face. O deslocamento de corpos estranhos para o interior do seio maxilar é uma complicação rara, que resulta de iatrogenias durante exodontias, traumas, entre outros. A presença deles nessa região pode provocar um processo inflamatório e desencadear sinusites. Objetivo: Relatar um caso referente à remoção de um corpo estranho deslocado para o interior do seio maxilar. Relato de caso: Paciente do sexo masculino, 29 anos, foi encaminhado ao Hospital Universitário do Oeste do Paraná por causa de episódios de sinusite recorrente. Ao exame físico extraoral, constatou-se ausência de anormalidades. Ao exame físico intraoral, apresentava discreto aumento de volume em fundo de sulco maxilar esquerdo de coloração normal, com dor à palpação, além de ausência dos elementos 27 e 28. Realizaram-se radiografia panorâmica e tomografia computadorizada, observando imagem sugestiva de elemento dentário em seio maxilar esquerdo. O tratamento instituído foi a remoção do corpo estranho (elemento 27), sob anestesia geral, pelo acesso de Caldwell-Luc. No acompanhamento pós-operatório de 60 dias, evidenciou-se ausência de sinais ou sintomas de sinusite. Conclusão: O diagnóstico nem sempre é fácil, portanto, o uso de exames de imagem é fundamental para o auxílio no diagnóstico e correto planejamento cirúrgico, minimizando sequelas e proporcionando melhor prognóstico.
Mechanism of Benzoinum in the Treatment of Ischemic Stroke Based on
Network Pharmacology and Molecular Docking
Authors: Ma Rong , Lu Danni , Xie Qian
Published: December 2024

Object:

Benzoinum is a traditional Chinese medicine used to treat ischemic stroke. However,
the mechanism of action of benzoinum for treating ischemic stroke still remains unclear. This
study aims to elucidate the mechanism of benzoinum for treating ischemic stroke based on network
pharmacology and molecular docking, which will explore its key targets and provide a basis and new
treatment ideas for its clinical application.

Methods:

Targets associated with ischemic stroke were retrieved from the Genecards database using
the keywords "Ischemic stroke" and "Cerebral ischemia." Network pharmacology analysis was conducted,
and a network diagram encompassing drugs, components, targets, and diseases was constructed.
The analysis was performed using the Intelligent Network Pharmacology Platform Unique
for Traditional Chinese Medicine (INPUT). PPI enrichment analysis was utilized to identify key
target genes; GO and KEGG enrichment analyses were carried out to ascertain the primary biological
processes, molecular functions, cellular components, and pathways involved. A target network diagram
was generated to identify the most enriched targets. The interaction between compounds and
targets was determined via molecular docking.

Results:

A total of 65 active ingredients from benzoinum were identified as potentially effective for
the treatment of ischemic stroke. Potential active substances, oleanolic acid, 2,3,5,7-
Tetrahydroxyflavone, naphthalene, eucalyptol, and benzoic acid were ranked according to their degree
values. In addition, 226 targets were found to be involved in the process. The PPI topology
analysis revealed that the core targets included TP53, JUN, STAT3, AKT1, PIK3CA, RELA,
MAPK1, MAPK3, TNF, and CXCL8. GO enrichment analysis yielded 6807 entries, with 5589 entries
in BP, 385 entries in CC, and 833 entries in MF. KEGG enrichment analysis resulted in 290
entries, primarily related to lipid and atherosclerosis, PI3K-Akt pathway, chemical carcinogenesis
receptor activation, IL-17 pathway, and TNF pathway. Molecular docking also demonstrated the
interactions between the principal compounds and their respective targets.

Conclusion:

Benzoinum appears to exert therapeutic effects on ischemic stroke through multiple
components, targets, and pathways, with a primary association with its anti-inflammatory properties.
However, further experimental validation is recommended to more accurately define its active constituents
and mechanisms of action.
Effectiveness and Safety of Metformin, Teneligliptin, and Glimepiride Combination Therapy in Type 2 Diabetes: A Quasi Experimental Clinical Trial
Authors: Manchi Rajesh Kumar , Chenchula Santenna , Haritha Manchi
Published: December 2024

Introduction:

Type 2 Diabetes Mellitus (T2DM) accounts for more than 95% of all
diabetes cases and is a leading cause of disability and death. This study aimed to evaluate the effectiveness
and safety of a combination therapy involving metformin, teneligliptin, and
glimepiride in patients diagnosed with T2DM.

Methods:

The present quasi-experimental clinical trial involved 300 adult T2DM patients. They
were divided into three groups: Group 1 (Metformin; n=100), Group 2 (Metformin + Teneligliptin;
n=100), and Group 3 (Metformin + Teneligliptin +; n=100). Along with demographic
data, we collected information on HbA1c, FBS, and PPBS levels, as well as fasting insulin, CPeptide,
HOMA-IR, QUICKI-IR, and lipid, renal, and hepatic profiles at baseline and after 3, 6,
and 12 months. Data analysis was performed using SPSS 21.0 software.

Results:

A total of 300 patients participated in the study. At the end of 12 months, triple-drug
therapy achieved significant glycemic control (HbA1c: 6.56±0.50%; P<0.0001) and reduced
FBS (7.6±1.41 mg/dl; P<0.0001), PPBS (9.39±2.14 mg/dl; P<0.0001), and fasting insulin
(11.26±2.5 IU; P<0.0001), C-peptide (2.01±2.29 ng/ml; P<0.0001), and insulin resistance by
HOMA-IR (3.74±0.7; P<0.0001). Favorable lipid profiles (P<0.0001) were noted versus other
groups. Despite renal and hepatic profile variations, values remained within the normal range.

Conclusion:

The combination of teneligliptin with metformin and glimepiride in T2DM patients
demonstrated significant improvements in glycaemic control, reduced insulin resistance, and
positive effects on lipid, renal, and hepatic profiles. Importantly, the therapy did not result in serious
adverse drug reactions, such as hypoglycemia. We need more RCTs to substantiate these
findings.
The Multifaceted Role of the Polyphenol Curcumin: A Focus on Type 2 Diabetes Mellitus
Authors: Campagna Roberto , Cecati Monia , Vignini Arianna
Published: December 2024

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by
chronic hyperglycemia, which often co-exists with other metabolic impairments. This condition
can damage various tissues and organs, resulting in the development of severe complications,
both microvascular, such as retinopathy, nephropathy, and neuropathy, and macrovascular, responsible
for an increased risk of cardiovascular diseases. Curcumin is the main bioactive molecule
found in the rhizomes of turmeric. Many studies have reported curcumin to exhibit antioxidant,
anti-inflammatory, anti-infectious, and anti-cancer properties; thus, there is an increasing
interest in exploiting these properties in order to prevent the rise or the progression of T2DM, as
well as its possible associated conditions. In this review, we have presented the current state-ofart
regarding the clinical trials that have involved curcumin administration and analyzed the possible
mechanisms by which curcumin might exert the beneficial effects observed in literature.
The Effect of Coffee Consumption on Individuals with Acute Stress Disorder
Authors:   Gajayana Malang University, Dwiputri Masayu Nandhia , Ramadhani Aji Fajar ,   State University of Surabaya
Published: December 2024

Caffeine, or the consumption of coffee with antioxidant content, has many benefits, one of which is reducing symptom stress in individuals. Research purposes This is to know the influence of consuming coffee against declining symptoms of stress in individuals with Stress Acute Disorder who experienced​ traumatic incidents. Research methods This quantitative approach experiment uses one group pre-test - post-test design. Pre-test and post-test will be measured using the Acute Stress Disorder Scale (ASDS) in individuals diagnosed with the Stress Acute Disorder. There are eight types of acute sex: men and women aged 20-25 years. Treatment is done by giving the subjects two glasses of coffee daily with a dose of 10 mg or equivalent with 25-35 ml of liquid espresso. The paired sample t-test showed results that the mean for the average result is 32,750 marks. This is the difference between the average values pre-test and post-test with a Sig of 0.000 (p < 0.50). The results of the paired sample t-test are known as t value = 55,499. This matter is worth positive because the average pre-test score is taller than the mean post-test score, meaning fewer stress symptoms exist in individuals with Stress Acute Disorder.
Evaluation of the Effect of Different Doses of X-Ray Irradiation on the Physicochemical and Microbiological Profiles of Liberica Green Coffee Beans
Authors:   Universitas Brawijaya, Khairunnisa Meutia Irdina , Kartika Annisa Aurora ,   Universitas Brawijaya, Sunarharum Wenny Bekti ,   Universitas Brawijaya, Mahatmanto Tunjung ,   Universitas Brawijaya
Published: December 2024

Liberica coffee has significant potential for cultivation and trade in Indonesia. The coffee trade requires effective post-harvest processing to maintain commodity quality. X-ray irradiation offers several advantages as a post-harvest processing method. However, research on X-ray irradiation remains limited. This study was designed to determine the effect of different doses of X-ray irradiation on the microbiological and physicochemical characteristics of Liberica green coffee beans and to identify the optimal dose for treatment. The research employed a randomized block design (RBD) method with five different doses of X-ray irradiation: 0 kGy, 2.7 kGy, 5.4 kGy, 7.2 kGy, and 10.8 kGy. The results indicated that varying doses of X-ray irradiation had no discernible effect on the color, water, protein, and fat content of Liberica green coffee beans. However, differences in the X-ray irradiation dose significantly affected the degree of acidity (pH), caffeine content, total sugar, antioxidants, and phenol levels in the beans. Additionally, there was a decrease in the Total Plate Count (TPC) with increasing doses of X-ray irradiation. The best treatment achieved was at an irradiation dose of 7.2 kGy.
¿Amas tu IA?: Un ensayo sobre las influencias de la ontología cristiana y confuciana en la creatividad, la tecnología y el arte mediático.
Authors: Park Lisa SoYoung
Published: December 2024

Este artículo examina la orientación antropocéntrica y la visión crítica de la tecnología tal como se trazan en la doctrina teológica del cristianismo, en comparación con la perspectiva antropocósmica y facilitadora –pero menos crítica– establecida a través del confucianismo. Luego examina cómo estas distintas visiones del mundo tradicionales son amplificadas por los medios de comunicación masiva de nuestro entorno contemporáneo, los cuales pueden influir en el desarrollo y la recepción de la inteligencia artificial hoy en día en diferentes ubicaciones geográficas. A través de esta comparación, este artículo invita a los lectores a localizar las influencias invisibles que restringen nuestras suposiciones a priori al explorar y articular perspectivas culturales previamente ocluidas dentro del contexto del arte de los medios. A partir de ahí, el ámbito del arte de los nuevos medios es propuesto como un espacio y contexto propicio en el que se pueden observar, discutir y experimentar tales inclinaciones, con vistas a expandir y diversificar colectivamente las teorías y los discursos en el mundo del arte de los medios dominantes.
Modelo de gobierno de TI para centros de servicios compartidos del sector energético
Authors: Mazó Pozuelo Hernando Antonio , Torrado Castro Dairon Jesús
Published: December 2024

The Shared Services Centers (SSC) are presented as a business model based on a collaborative strategy that allows separating and centralizing activities, thus optimizing time and resources. In Colombia, the growth trends of these SSCs have significantly increased. This study analyzes the structure of the components of IT Governance models for Shared Services Centers in the energy sector through a quantitative approach with descriptive scope. It begins with a state-of-the-art review of the SSCs and the issues they face, followed by a description of the IT governance model elements, including components such as Processes, Organizational Structures, Principles, Policies and Reference Frameworks, Culture, Ethics and Behavior, People, Skills and Competences, and Services, Infrastructure and Applications.
Phenolic and volatile compounds, total protein content, antioxidant and antidiabetic activities of leaves of Palicourea padifolia (Rubiaceae)
Authors: Infante-Rodríguez Dennis Adrián , Aguilar-Méndez Mario J. , Landa-Cansigno Cristina , Juaréz-Trujillo Naida , Vásquez-Morales Suria Gisela , Valenzuela-González Jorge E. , Kiel-Martínez Ana Luisa , Monribot-Villanueva Juan Luis , Guerrero-Analco José Antonio
Published: December 2024

Background and Aims: Information on the chemical composition and biological activities of Palicourea padifolia is scarce. This study aimed to 1) measure the total content of nutrients, macroelements, proteins, and secondary metabolites, 2) conduct metabolomic analyses on phenolic and volatile compounds, and 3) assess the antioxidant and antidiabetic activities from the leaves of this species.
Methods: The total content of nutrients and macroelements was determined by spectroscopic, spectrometric, and spectrophotometric approaches. The total content of alkaloids, terpenes, phenols, flavonoids, tannins, and proteins was determined by spectrophotometric approaches. Volatile and phenolic compounds were identified by gas and liquid chromatography, respectively, coupled to mass spectrometers. The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, and the antidiabetic potential was determined by the inhibition of α-glucosidase.
Key results: The leaves of P. padifolia were rich in Ca, Na, and Mg and exhibited a low protein content. The leaf methanolic extract (LME) contained high levels of alkaloids, phenols, and terpenes, while flavonoids were present at low concentrations. The major phenolic compounds identified were chlorogenic acid, scopoletin, trans-cinnamic acid, and (-)-epicatechin. In addition, a leaf petroleum ether extract (LPE) contained mainly phytol, palmitic acid, (Z)-7-tetradecenal, octadecanoic acid and linoleic acid. The leaves exhibited a high antioxidant capacity, inhibiting DPPH and ABTS radicals, and the LME showed low inhibition of α-glucosidase enzyme.
Conclusions: Palicourea padifolia leaves had a rich composition of cations such as Ca, Na, and Mg. In addition, the LME contained alkaloids, terpenes, lipids, and phenolics, which support the potent antioxidant capacity. In contrast, the LME exhibited a low inhibition of the α-glucosidase enzyme.
Assessing the Effect of Project-Based Learning on Managerial Skills in Relation to Student Creativity
Authors: Falah Apria Nur Eka , Soeryanto Soeryanto , Agung Achmad Imam , Rijanto Tri , Pramono Aditya
Published: December 2024

Enhancing managerial skills and creativity is crucial for students in technical fields in the rapidly evolving industry. This study explores the impact of project-based learning (PBL) on students' managerial skills and creativity in CNC machining engineering. The research employs a factorial exposure design, focusing on three key variables: project-based learning as the independent variable, managerial skills as the dependent variable, and creativity as a mediating variable. Data were collected using a Likert scale and analyzed through linear regression techniques. The research involved two classes from grade 11 in the machining engineering department of SMK YPI Darussalam 1 Cerme, which engaged in PBL activities. The findings reveal that project-based learning significantly influences students' managerial skills and creativity. While PBL's effect on managerial skills remains substantial, even when creativity is considered a mediating variable, creativity itself does not significantly mediate this relationship. This suggests that while PBL effectively enhances managerial abilities, it also promotes creativity in students, contributing to a richer educational experience. These results highlight the effectiveness of PBL as a pedagogical approach in the CNC machining curriculum. Although creativity does not moderate the relationship between PBL and managerial skills, PBL is valuable in developing both technical skills and creative potential, thus preparing students to meet future industry challenges effectively.
Composition and dynamics of bladder, vaginal and bowel microbiota during three trimesters in healthy pregnant women
Authors: Naboka Yu. L. , Vorobyeva N. V. , Gudima I. A. , Sinyavskaya T. G. , Ismailov R. S. , Naber K. G. , Kogan M. I.
Published: December 2024

Introduction. The microbiota dynamics of the core biotopes during pregnancy are hardly studied, although changes in these compartments have an important role in both the functioning of the female organism and foetal development.

Objective. To study the dynamics and interactions of changes in bladder, vaginal and bowel microbiota in healthy pregnant women over three trimesters (TRI-1, 2, 3).

Materials & Methods. Study design: a single-centre comparative observational longitudinal study. Thirty out of first-time 220 pregnant women were selected for screening at the antenatal clinic from 2021 to 2022. All pregnant women underwent sampling at T-1, 2, 3: mid-stream bladder urine samples, posterior vaginal swabs and faecal masses were collected for culture study. After a special pre-culture preparation, samples were examined on an expanded set of nutrient media (n = 13) using special cultivation (aerobic-anaerobic) conditions. Based on the research results, identification frequencies (IDFs), microbial load values (MLVs) and microbial co-occurrence coefficients between the different biotopes were estimated.

Results. Culture study revealed various bacteria in each biotope investigated during all TRIs. In the urine, aerobes and anaerobes were observed from TRI-1 to TRI-3 with different IDFs, but no taxa showed a stable IDFs. In the vagina, IDFs of bacteria were similar to urinary. The bowel microbiota was the most stable biotope remained almost unchanged during pregnancy. In the urine and vagina, mean MLVs of most aerobes and anaerobes did not change significantly throughout pregnancy. In the bowel, MLVs were consistently higher than in the urine and vaginal swabs. According to the co-occurrence analysis bladder-vagina and bladder-bowel biotopes showed significantly more interconnections between microorganisms in all TRIs.

Conclusion. The observed microbiota structure during all TRIs is associated with uncomplicated gestation. These results will be valuable for studying changes of microbiota in complicated pregnancies.
Assessment of novel biomarkers of renal dysfunction associated with lower urinary tract symptoms in men with benign prostatic hyperplasia
Authors: Startsev V. Yu. , Dudarev V. A.
Published: December 2024

Introduction. The problem of diagnostics and treatment of patients with complex lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) remains highly relevant. Clinical diagnostic methods do not always allow timely prediction of changes in renal, upper and lower urinary tract function with different types of treatment intervention. The search for potential biomarkers allowing minimally invasive assessment of the bladder and renal function condition seems to be a promising direction of scientific research.

Objective. To identify potential urine and serum biomarkers allowing to assess renal function in patients with LUTS/BPH.

Materials & methods. The study included 69 patients with LUTS/BPH and subsequently divided them into two groups. Group 1 included 48 patients with moderate LUTS who received combination therapy with alpha-1 adrenergic blockers (AABs) and 5-alpha reductase inhibitors (5ARIs). Group 2 included 21 patients with severe LUTS/BPH. Patients of group 2 underwent surgical treatment: transurethral resection of the prostate. In addition to standard research methods (IPSS, voiding diaries, laboratory, urodynamic and radiation techniques), to search for potential biomarkers in serum and urine, concentrations of: insulin-like growth factor binding protein-7 (IGFBP7), B-Cross Laps, Cystatin C, OPN, trefoil factor (TFF3), uromodulin, Clusterin, lactate dehydrogenase (LDH). The follow-up period for patients was 12 months.

Results. The study noted that IGFBP7, Cystatin C, TFF3 in the blood serum, as well as LDH, Clusterin in the urine are associated with the severity of LUTS/BPH. Serum biomarker levels were initially higher in patients with severe LUTS compared to patients with moderate LUTS (group 1). The levels of these substrates decreased in patients of all groups during treatment (conservative therapy, surgical interventions for BPH). When assessing urinary biomarkers, the greatest decrease in Clusterin level by the end of follow-up was registered in group 1 patients, the least pronounced in group 2 patients. The initial value of LDH was twice higher in group 2 vs group 1 and progressively decreased after surgical treatment of bladder outlet obstruction.

Conclusion. Biomarkers used to assess renal dysfunction in the development of LUTS/BPH are a promising area of scientific research. Panels of new markers will enable to predict renal dysfunction in patients with moderate-to-severe LUTS, which will improve the quality of medical care for this category of patients.
Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics
Authors: Petrov S. B. , Arnautov A. V. , Nikulina K. A. , Reva S. A. , Tsaregorodtseva A. D. , Tikhonova Yu. A.
Published: December 2024

Introduction. Testicular germ cell tumor (GCT) is a rare pathology that accounts for about 1% of all malignant neoplasms in men, while cryptorchidism is one of the main risk factors. We present a clinical case of a GCT of an undescended testicle in patient with bilateral cryptorchidism and male to female sexual characteristics.

Objective. To present a rare clinical case of testicular GCT in a patient with disorder of sex development (DSD).

Clinical case. A 32-year-old patient with a history of bilateral cryptorchidism with a large neoplasm of the right undescended testis was detected during examination at the Department of Andrology and Oncourology No. 6 of the Pavlov State Medical University. Based on MRI scans, a cavity formation interpreted as an enlarged left seminal vesicle was fixed to the lower pole of the right testicle. Bilateral removal of the left and right testicles (tumour-affected) was performed. The seminal duct was detected from the lower pole of the formation, passing into a blindly ending soft tissue cavity formation (in shape and structure resembling a uterus) — its removal was performed. Histological examination showed that the neoplasm was a typical seminoma of the right testicle, pT2. The soft tissue cavity was represented by a rudimentary uterus with fallopian tubes. Adjuvant chemotherapy was performed.

Conclusion. We demonstrate a rare clinical case of a GCT of the undescended testis in a patient with bilateral cryptorchidism, DSD (46, XY), and Müllerian duct persistence syndrome. These nosologies require early diagnosis and treatment.
Robot-assisted partial nephrectomy in difficult renal masses using isolated combined ‘drug & cold’ ischemia in situ
Authors: Oganyan V. A. , Karelskaya N. A. , Monakov D. M. , Demidova V. S. , Lebedeva A. N. , Gritskevich A. A.
Published: December 2024

The paper presents the results of surgical treatment of 14 patients with renal masses undergone partial nephrectomy on the Da Vinci Si and Da Vinci Xi robotic systems using ‘drug & cold’ ischemia. The advantages of the original technique, such as long-term safe renal ischemia, nephron sparing, minimal blood loss with no hemotransfusions and short length of hospital stay were presented.
Chinese Clinical Named Entity Recognition With Segmentation Synonym Sentence Synthesis Mechanism: Algorithm Development and Validation
Authors: Tang Jian , Huang Zikun , Xu Hongzhen , Zhang Hao , Huang Hailing , Tang Minqiong , Luo Pengsheng , Qin Dong
Published: December 2024

Background

Clinical named entity recognition (CNER) is a fundamental task in natural language processing used to extract named entities from electronic medical record texts. In recent years, with the continuous development of machine learning, deep learning models have replaced traditional machine learning and template-based methods, becoming widely applied in the CNER field. However, due to the complexity of clinical texts, the diversity and large quantity of named entity types, and the unclear boundaries between different entities, existing advanced methods rely to some extent on annotated databases and the scale of embedded dictionaries.

Objective

This study aims to address the issues of data scarcity and labeling difficulties in CNER tasks by proposing a dataset augmentation algorithm based on proximity word calculation.

Methods

We propose a Segmentation Synonym Sentence Synthesis (SSSS) algorithm based on neighboring vocabulary, which leverages existing public knowledge without the need for manual expansion of specialized domain dictionaries. Through lexical segmentation, the algorithm replaces new synonymous vocabulary by recombining from vast natural language data, achieving nearby expansion expressions of the dataset. We applied the SSSS algorithm to the Robustly Optimized Bidirectional Encoder Representations from Transformers Pretraining Approach (RoBERTa) + conditional random field (CRF) and RoBERTa + Bidirectional Long Short-Term Memory (BiLSTM) + CRF models and evaluated our models (SSSS + RoBERTa + CRF; SSSS + RoBERTa + BiLSTM + CRF) on the China Conference on Knowledge Graph and Semantic Computing (CCKS) 2017 and 2019 datasets.

Results

Our experiments demonstrated that the models SSSS + RoBERTa + CRF and SSSS + RoBERTa + BiLSTM + CRF achieved F1-scores of 91.30% and 91.35% on the CCKS-2017 dataset, respectively. They also achieved F1-scores of 83.21% and 83.01% on the CCKS-2019 dataset, respectively.

Conclusions

The experimental results indicated that our proposed method successfully expanded the dataset and remarkably improved the performance of the model, effectively addressing the challenges of data acquisition, annotation difficulties, and insufficient model generalization performance.