bluuebunny/crossref_metadata_2025 huggingface dataset:
Uncommon toxic epidermal necrolysis -like presentation of cutaneous lupus erythematosus: A series of 6 cases
Authors: Rajagopal Varun , Bains Anupama , Kannan Karthick , Bhardwaj Abhishek , Elhence Poonam
Published: May 2024

TEN like Lupus erythematosus is an uncommon life-threatening variant of Lupus erythematosus. It is usually associated with flares of systemic lupus erythematosus and also because of widespread skin erosions, it can cause acute skin failure. It is often confused with drug induced TEN, however the management of both the diseases is different and hence correct diagnosis becomes crucial. In this study we aimed to assess the clinical characteristics and outcome of TEN like LE in the Indian population. All patients satisfying ACR/EULAR 2019 criteria for SLE and clinically diagnosed with TEN like LE were retrospectively reviewed. A total of 6 patients were identified. All patients were female. Except 1 patient who presented de-novo, the others had pre-existing symptoms of connective tissue disease. Half of the patients had palmoplantar involvement. Mucosal involvement was only mild. Majority had systemic involvement in the form of nephritis followed by arthralgia, autoimmune hepatitis and autoimmune hemolytic anemia.
I married a Traveller: An Interpretative Phenomenological Analysis of the lived experiences of women marrying into the Travelling community and its impact to their identity
Authors: Johnson Kayleigh , Ncube Mvikeli , Fido Dean
Published: May 2024

Policy developments associated with increased lifestyle-related regulations have compelled Travellers to re-assess their social worlds and adapt accordingly. Adopting a social constructionist epistemological stance, this qualitative study drew upon the Identity Process Theory, alongside Interpretative Phenomenological Analysis (IPA) as a broad framework to (1) explore the way in which non-Traveller women experience a sense of community integration upon marrying into the Traveller community, (2) to explicate the extent to which their experiences of integration impact upon their own identity, and (3) to develop an understanding of how these lived experiences inform the changes within Traveller culture through the process of integration. Semi-structured interviews were conducted with six women aged between 28–42 years living within the UK. Guided by the principles of IPA, three superordinate themes, each consisting of two subordinate themes emerged from the analysis: ‘Joining the culture’, ‘Cultural Clashes’, and ‘Changes to the self’. The findings highlighted that participant’s experienced interpersonal conflict and continuous negotiations between continuity and discontinuity, that had either positive or negative impacts to their individual identity. This paper has important implications for professionals who aim to provide support and enhance the overall wellbeing of individuals living between these two contrasting cultures.
A numerical model simulating cyclic behavior of high-strength steel
Authors: Cho EunSeon , Han Sang Whan
Published: May 2024

High-strength steel (HSS) can effectively and economically design structural members that withstand large forces induced by extreme events such as earthquakes. To evaluate the seismic performance of HSS members and structures using nonlinear finite element (FE) analyses, using an accurate material model is important, which can simulate the inelastic cyclic behavior of the HSS. The peculiar material behavior of HSS needs to be considered in the model. This study used a combined hardening model to construct the material model. The configuration of the model and the constituent model parameter values are determined to precisely simulate the low-cycle fatigue (LCF) behavior of HSS. An efficient particle swarm optimization (PSO) algorithm is used to determine parameter values with LCF test data of 54 individual HSS coupons. In additions, to conveniently determine the model parameter values with only monotonic tensile test data instead of conducting expensive LCT tests, empirical equations are proposed. It is shown that the LCF curves of HSS can be accurately simulated using the constructed material model with the proposed equations.
Seismic response of structures with friction pendulum inerter system (FPIS) under near-fault earthquakes
Authors: Xue Zhang , Jinjie Men , Qiang Rong
Published: May 2024

Near-fault ground motions with high acceleration peaks and long-period velocity pulses pose a serious threat to the reliability of engineering structures. To reduce the displacement of isolation layer and improve the seismic performance of superstructure under the near-fault ground motions, a composite isolation system, which is composed of friction pendulum system (FPS) and inerter system, namely FPIS, was used in this paper. Based on D’Alembert’s principle, the nonlinear motion equations of a base-isolated structure with FPIS were established. The damping effect of two different mechanical layouts of FPIS subsystems, i.e, series-parallel inerter system-I-FPS(SPIS-I-FPS) or series-parallel inerter system-II-FPS(SPIS-II-FPS), were investigated in this study. The strong nonlinearity of FPIS was considered, and the inerter system parameters were designed based on the principle of maximum damping enhancement. The fourth-order Runge-Kutta approach was used to solve the dynamic response of a multi-degree-of-freedom system under seismic excitations. The effectiveness of FPIS was verified by comparing the isolation layer displacement and the acceleration of superstructure calculated by MATLAB with the friction pendulum system and viscous damper (FPS-VD). The nonlinear time history analysis results indicate that within a certain additional damping range, the SPIS-I-FPS subsystem performs effectively than SPIS-II-FPS in reducing the superstructure acceleration and isolation layer displacement. To increase the energy dissipation efficiency of structures, it is recommended to increase the design parameters of the inerter system and control the friction coefficient of FPS within the range of 0.05∼0.10.
In Brief
Authors: Muzzerall Parker , Liu Sophie X. , Uscola Colter J. , van Stee Elena G.
Published: May 2024

Generational wealth, the speed of science, and women telling stories: A snapshot of new research.
Navigating the Hypervisibility and Invisibility of Mixed-Race Families
Authors: Johnson Katherine
Published: May 2024

U.S. multiracial families are paradoxically regarded as representatives of a post-racial ideal and as anomalies that challenge assumptions. Here, Black-White couples discuss the pressures they feel to “perform” family when facing racial surveillance and erasure.
Why Believe Conspiracy Theories?
Authors: Jordan Meggan M. , Whitmer Jennifer M.
Published: May 2024

Beliefs, even conspiratorial ones, do not occur in a vacuum: they reflect social conditions and fulfill important identity needs, including access to social connection and playfulness; distinction, purpose, and legitimacy; and a sense of certainty, justice, and order.
Grieving Overdose
Authors: Campbell Emily B.
Published: May 2024

Emily B. Campbell on using grief to fuel social and political action.
See It Through My Eyes
Authors: Alfaro Andrea Román
Published: May 2024

Andrea Román Alfaro on seeing a Peruvian shantytown through the lens(es) of its children.
Overlooked Consequences
Authors: Taylor Catherine J.
Published: May 2024

Catherine J. Taylor on life under restrictive abortion laws.
Scotus Rewriting the History of Race in America
Authors: Nelson Robert L.
Published: May 2024

Robert L. Nelson on the racial ideology of a conservative-majority court.
Glue embolization of ruptured pseudoaneurysm secondary to reversible cerebral vasoconstriction syndrome: An illustrative case
Authors: Tshibangu Mpuekela , McGuire Laura Stone , Theiss Peter , Alaraj Ali
Published: May 2024

Background

Reversible cerebral vasoconstriction syndrome (RCVS) is an increasingly recognized condition characterized by thunderclap headache with or without other neurological deficits and diffuse vasoconstriction of cerebral arteries. Altered cerebrovascular tone may produce hemorrhage or stroke.

Methods

A retrospective review of patients with RCVS at our institution (2000–2023) yielded one case of pseudoaneurysm secondary to RCVS.

Results

Diagnostic cerebral angiogram demonstrated diffuse multifocal segmental narrowing consistent with RCVS and a left M4 pseudoaneurysm in proximity to the cortical hemorrhage. The pseudoaneurysm was treated with branch vessel sacrifice using nBCA glue in a 1 : 3 ratio with ethiodized oil. After securing the source of hemorrhage, the patient received an intra-arterial infusion of Verapamil.

Conclusion

This unique presentation of pseudoaneurysm secondary to RCVS in this patient highlights the impact of hemodynamic alteration as a possible source of bleeding and demonstrates a potential management strategy. Endovascular management with nBCA glue embolization successfully treated this lesion.
Digital disparities beyond the stably housed: Researching global homelessness and mobile media
Authors: Humphry Justine , Hartmann Maren , Marler Will , Lowis David
Published: May 2024

As the study of mobile media and communication matures, an important expansion in focus is to explore the experiences of people and communities living on the peripheries of social and economic power. In this special issue, we ask what happens when the stability of the “home” is pulled out from under our assumptions of mobile media and communication, as well as what happens when we shift our attention to the Global South. Additionally, mobility has a special relation to homelessness and, in turn, to media that is mobile. It enters both as a resource and a liability for the unstably housed in contexts around the globe. Tackling this combination of mobility, media, and homelessness, this special issue asks: What kind of opportunity is a mobile device for those who lack stable shelter? How do different experiences and drivers of homelessness interact with the possibilities of mobile media? What are communities and institutions doing to provide assistance to those at risk of, or experiencing, homelessness through mobile technologies? The articles gathered in this issue draw attention to homelessness as a set of diverse experiences with significant consequences for well-being and unique connections to mobile media. The authors challenge the taken-for-granted focus on the stably housed by studying those without access to the same basic need. We take an international perspective on contemporary homelessness to foreground its global existence and diverse expressions across a range of national contexts, and to challenge the predominant focus on North America and Western Europe in existing literature.
Music and Visual Imagery: Electroencephalographic Evidence of General and Modality-Specific Activity Patterns
Authors: Pérez-Acosta Gabriela , Yanez-Suarez Oscar , Porta-García Miguel Ángel , Díaz José-Luis
Published: May 2024

There is a substantial corpus of evidence about the shared brain mechanism between imagery and perception. However, the psychophysiological exploration concerning possible mechanisms underlying modality-independent mental imagery and how much it involves or depends on other cognitive processes, such as attention and memory, is still scant. To address this, we performed an electroencephalographic (EEG) study to compare brain activity related to auditory/musical and visual imagery to identify shared and specific activity patterns. The electrical brain activity of 12 musicians was measured while they perceived or imagined either auditory or visual stimuli with two levels of complexity. Mean power differences were calculated between tasks and conditions for alpha, beta, and gamma bands. For the alpha band, an increase in mean relative power was observed in occipital and parietal areas throughout the paradigm. Regarding level of complexity of the imagery tasks, same-modality contrasts (i.e., auditory simple vs. auditory complex) showed small-magnitude differences in power that were only significant for a few locations along the midline. However, when comparing across imagery modalities (i.e., auditory simple vs. visual simple), the significantly different locations increased in number and were mainly distributed in central and occipital regions, where differences were positive for mean alpha power and negative for beta and gamma bands. With respect to resting (baseline) power, the main differences were observed as a wider distribution of beta power increments in relation to visual imagery tasks, and similarities were identified for both auditory and visual imagery tasks as an increase in gamma power in right frontal locations, increased frontal and pre-frontal beta power, and some bilateral parietal increased beta power. These results seem to support the hypothesis that mental imagery, to some extent, involves areas related to memory retrieval, attention, semantic processing, and motor preparation, in addition to the primary areas corresponding to each sensory modality.
Understanding Students’ Mobile Technology Usage Behavior During COVID-19 Through Use & Gratification and Theory of Planned Behavior
Authors: Warraich Nosheen Fatima , Irfan Momina , Ali Irfan
Published: May 2024

The main purpose of the study was to validate the Use and Gratification (U&G) theory and examine the effect of U&G (entertainment, information seeking, and socializing) on the theory of planned behavior (Perceived behavioral control and attitude toward behavior) among students regarding mobile technology usage in COVID-19. Quantitative research design was employed for conducting the study. Data was collected using the survey method. The population consisted of students currently enrolled in a public sector university in Lahore. A questionnaire in online form was used for collecting data from students. SPSS software was used for descriptive analysis and SmartPLS was used for path analysis and hypotheses testing. The study identified that there was an insignificant impact of getting entertainment on students’ attitudes and their perceived control toward mobile technology use during the COVID-19 pandemic. Findings showed that students used mobile technology for information seeking and socializing as there was a significant impact of information seeking and socializing on their attitude toward the use of mobile technology. Current study provides insight into the usage behavior of students regarding mobile technology during the COVID-19 pandemic. It also provides, how mobile technology motivators (getting entertainment, information seeking, and socializing) work for mobile technology usage behavior in crises, especially COVID-19 pandemic. Findings are helpful for government authorities in decision-making regarding the provision of information through mobile technology during emergencies.
Buyer-Backed Purchase Order and Advance Payment Discount Financing Under Carbon Trade Revenue-Sharing Contract
Authors: Cao Guozhao , Zhang Yanqing
Published: May 2024

The promotion of low-carbon production is a crucial aspect of sustainable development, and carbon trading has proven to be an effective means of achieving this goal. However, the limited capital hinders small and medium-sized enterprises (SMEs) from achieving low-carbon production. Thus, this paper examines a low-carbon supply chain comprising a financially constrained manufacturer and a well-funded retailer. We propose a game-theoretical model that addresses the financial constraints of the manufacturer through buyer-backed purchase order financing (BPOF) or advance payment discount (APD) with carbon trading revenue-sharing contracts. We investigate the determination of pricing and carbon emission reduction strategies by firms utilizing diverse financing models. We find that the total amount of carbon emission reduction increases with the manufacturer’s carbon trade revenue-sharing ratio. The financing rate of BPOF has a negative impact on the amount of carbon emission reduction, while the discount rate of APD will not affect either the carbon emission reduction or the revenue of the supply chain. Among the two financing strategies, APD is optimal for maximizing profit and promoting low-carbon development throughout the supply chain.
Understanding the Unique Factors Affecting South Asian International (SAI) Student Transitions into PhD Programs in the US: An Interpretative Phenomenological Analysis
Authors: Asif Muhammad Zaka , Jain Chaitya , Dolan Erin L.
Published: May 2024

International students comprise over 50% of the graduate student population in the life sciences in the US, over 70% of whom are Asian. Research that aims to understand international students’ experiences has often treated Asian students as a monolith, discounting significant cultural and historical differences between regions in Asia that may affect students’ motivations for pursuing graduate degrees, their experiences in graduate school, and their identities as scientists in training. To begin to understand the experiences of SAI students as they transition to PhD programs in the sciences, we conducted an exploratory study in which we interviewed 10 SAI students and 12 US native students during the first six months of their doctoral programs. We performed a content analysis of the interview data with the aim of identifying factors that shaped students’ doctoral transitions. We then selected factors that were distinctive to SAI students. Finally, we carried out an interpretative phenomenological analysis to understand and describe the following factors that SAI students experienced as influencing their doctoral transitions: prior exposure to research; opportunities for networking; challenges with and affordances for acculturation; attitudes toward and understanding of mental health issues; financial affordances and constraints of pursuing a PhD, and barriers to communication. The results of this work have the potential to be useful to graduate programs seeking to ease SAI students’ transition to doctoral programs.
Clinical Disease Measures in Palmoplantar Pustulosis: A Scoping Review
Authors: Tan Alice J. , Archila Marjorie , Mita Carol , Edelen Maria O. , Noe Megan H.
Published: May 2024

Background

Palmoplantar pustulosis (PPP) is a rare, relapsing, disease characterized by pustules, pain, and fissuring. PPP is often combined with psoriasis, most commonly palmar plantar psoriasis, in clinical trials which further complicates our understanding of treatment response.

Objective

The objective of this scoping review is to describe all outcome measures (clinician-reported & patient-reported) used in previous PPP clinical trials.

Methods

A search was conducted in Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) for clinical trials and prospective cohort studies performed in adults with PPP, with an intervention and pre-determined outcomes collected at pre specified time points.

Results

The initial search identified 1839 records, of which 69 met our inclusion criteria. The studies were published between 1970–2023 and included a total of 3301 patients. The most common primary study outcome was the clinician-reported Palmoplantar Pustulosis Psoriasis Area Severity Index (ppPASI) ( n = 39, 56.5%) and an endpoint of 12 weeks ( n = 23, 33.3%). Other common clinician reported outcomes identified were pustule count ( n = 26, 37.7%) and the Physician Global Assessment ( n = 16, 23.2%) The majority of studies ( n = 43, 62.3%) did not include any patient reported outcome measures. Of those that did include patient reported outcome measures, the Dermatology Life Quality Index was most utilized ( n = 17, 24.6%), followed by symptoms-specific instruments measuring pain ( n = 11, 15.9%) and itch ( n = 6, 8.7%).

Conclusions

While the clinician-reported ppPASI has become the standard primary outcome in PPP clinical trials, there is still considerable heterogeneity and lack of specificity in the patient reported outcomes used.
Fusion-harboring mast cells can explain molecular positivity in flow cytometric MRD-negative core-binding factor AML
Authors: Cook Jacqueline A. , Lott Loren , Perry Jenna , Eckel Ashley M. , Xu Dongbin , Hudson Chad A. , Wells Denise A. , Loken Michael R. , Menssen Andrew J.
Published: May 2024

Molecular measurable residual disease can persist in core-binding factor acute myeloid leukemia in otherwise disease-free patients. Utilizing cell sorting followed by fluorescent in situ hybridization, we show that detection is due to mast cells.
The DEP1 Mutation Improves Stem Lodging Resistance and Biomass Saccharification by Affecting Cell Wall Biosynthesis in Rice
Authors: Wang Ye , Wang Meihan , Yan Xia , Chen Kaixuan , Tian Fuhao , Yang Xiao , Cao Liyu , Ruan Nan , Dang Zhengjun , Yin Xuelin , Huang Yuwei , Li Fengcheng , Xu Quan
Published: May 2024

Background

Plant cell walls have evolved precise plasticity in response to environmental stimuli. The plant heterotrimeric G protein complexes could sense and transmit extracellular signals to intracellular signaling systems, and activate a series of downstream responses. dep1 (Dense and Erect Panicles 1), the gain-of-function mutation of DEP1 encoding a G protein γ subunit, confers rice multiple improved agronomic traits. However, the effects of DEP1 on cell wall biosynthesis and wall-related agronomic traits remain largely unknown.

Results

In this study, we showed that the DEP1 mutation affects cell wall biosynthesis, leading to improved lodging resistance and biomass saccharification. The DEP1 is ubiquitously expressed with a relatively higher expression level in tissues rich in cell walls. The CRISPR/Cas9 editing mutants of DEP1 (dep1-cs) displayed a significant enhancement in stem mechanical properties relative to the wild-type, leading to a substantial improvement in lodging resistance. Cell wall analyses showed that the DEP1 mutation increased the contents of cellulose, hemicelluloses, and pectin, and reduced lignin content and cellulose crystallinity (CrI). Additionally, the dep1-cs seedlings exhibited higher sensitivity to cellulose biosynthesis inhibitors, 2,6-Dichlorobenzonitrile (DCB) and isoxaben, compared with the wild-type, confirming the role of DEP1 in cellulose deposition. Moreover, the DEP1 mutation-mediated alterations of cell walls lead to increased enzymatic saccharification of biomass after the alkali pretreatment. Furthermore, the comparative transcriptome analysis revealed that the DEP1 mutation substantially altered expression of genes involved in carbohydrate metabolism, and cell wall biosynthesis.

Conclusions

Our findings revealed the roles of DEP1 in cell wall biosynthesis, lodging resistance, and biomass saccharification in rice and suggested genetic modification of DEP1 as a potential strategy to develop energy rice varieties with high lodging resistance.
MR-GGI: accurate inference of gene–gene interactions using Mendelian randomization
Authors: Oh Wonseok , Jung Junghyun , Joo Jong Wha J.
Published: May 2024

Background

Researchers have long studied the regulatory processes of genes to uncover their functions. Gene regulatory network analysis is one of the popular approaches for understanding these processes, requiring accurate identification of interactions among the genes to establish the gene regulatory network. Advances in genome-wide association studies and expression quantitative trait loci studies have led to a wealth of genomic data, facilitating more accurate inference of gene–gene interactions. However, unknown confounding factors may influence these interactions, making their interpretation complicated. Mendelian randomization (MR) has emerged as a valuable tool for causal inference in genetics, addressing confounding effects by estimating causal relationships using instrumental variables. In this paper, we propose a new statistical method, MR-GGI, for accurately inferring gene–gene interactions using Mendelian randomization.

Results

MR-GGI applies one gene as the exposure and another as the outcome, using causal cis-single-nucleotide polymorphisms as instrumental variables in the inverse-variance weighted MR model. Through simulations, we have demonstrated MR-GGI's ability to control type 1 error and maintain statistical power despite confounding effects. MR-GGI performed the best when compared to other methods using the F1 score on the DREAM5 dataset. Additionally, when applied to yeast genomic data, MR-GGI successfully identified six clusters. Through gene ontology analysis, we have confirmed that each cluster in our study performs distinct functional roles by gathering genes with specific functions.

Conclusion

These findings demonstrate that MR-GGI accurately inferences gene–gene interactions despite the confounding effects in real biological environments.
Exploring agro-morphological and fiber traits diversity in cotton (G. barbadense L.)
Authors: Salama Ehab A. A. , Farid Mona A. , El-Mahalawy Youssef A. , El-Akheder A. A. A. , Aboshosha Ali A. , Fayed Aysam M. , Yehia W. M. B. , Lamlom Sobhi F.
Published: May 2024

Cotton (Gossypium barbadense L.) is a leading fiber and oilseed crop globally, but genetic diversity among breeding materials is often limited. This study analyzed genetic variability in 14 cotton genotypes from Egypt and other countries, including both cultivated varieties and wild types, using agro-morphological traits and genomic SSR markers. Field experiments were conducted over two seasons to evaluate 12 key traits related to plant growth, yield components, and fiber quality. Molecular diversity analysis utilized 10 SSR primers to generate DNA profiles. The Molecular diversity analysis utilized 10 SSR primers to generate DNA profiles. Data showed wide variation for the morphological traits, with Egyptian genotypes generally exhibiting higher means for vegetative growth and yield parameters. The top-performing genotypes for yield were Giza 96, Giza 94, and Big Black Boll genotypes, while Giza 96, Giza 92, and Giza 70 ranked highest for fiber length, strength, and fineness. In contrast, molecular profiles were highly polymorphic across all genotypes, including 82.5% polymorphic bands out of 212. Polymorphism information content was high for the SSR markers, ranging from 0.76 to 0.86. Genetic similarity coefficients based on the SSR data varied extensively from 0.58 to 0.91, and cluster analysis separated genotypes into two major groups according to geographical origin. The cotton genotypes displayed high diversity in morphology and genetics, indicating sufficient variability in the germplasm. The combined use of physical traits and molecular markers gave a thorough understanding of the genetic diversity and relationships between Egyptian and global cotton varieties. The SSR markers effectively profiled the genotypes and can help select ideal parents for enhancing cotton through hybridization and marker-assisted breeding.
Epitranscriptome insights into Riccia fluitans L. (Marchantiophyta) aquatic transition using nanopore direct RNA sequencing
Authors: Maździarz Mateusz , Krawczyk Katarzyna , Kurzyński Mateusz , Paukszto Łukasz , Szablińska-Piernik Joanna , Szczecińska Monika , Sulima Paweł , Sawicki Jakub
Published: May 2024

Background

Riccia fluitans, an amphibious liverwort, exhibits a fascinating adaptation mechanism to transition between terrestrial and aquatic environments. Utilizing nanopore direct RNA sequencing, we try to capture the complex epitranscriptomic changes undergone in response to land-water transition.

Results

A significant finding is the identification of 45 differentially expressed genes (DEGs), with a split of 33 downregulated in terrestrial forms and 12 upregulated in aquatic forms, indicating a robust transcriptional response to environmental changes. Analysis of N6-methyladenosine (m6A) modifications revealed 173 m6A sites in aquatic and only 27 sites in the terrestrial forms, indicating a significant increase in methylation in the former, which could facilitate rapid adaptation to changing environments. The aquatic form showed a global elongation bias in poly(A) tails, which is associated with increased mRNA stability and efficient translation, enhancing the plant’s resilience to water stress. Significant differences in polyadenylation signals were observed between the two forms, with nine transcripts showing notable changes in tail length, suggesting an adaptive mechanism to modulate mRNA stability and translational efficiency in response to environmental conditions. This differential methylation and polyadenylation underline a sophisticated layer of post-transcriptional regulation, enabling Riccia fluitans to fine-tune gene expression in response to its living conditions.

Conclusions

These insights into transcriptome dynamics offer a deeper understanding of plant adaptation strategies at the molecular level, contributing to the broader knowledge of plant biology and evolution. These findings underscore the sophisticated post-transcriptional regulatory strategies Riccia fluitans employs to navigate the challenges of aquatic versus terrestrial living, highlighting the plant’s dynamic adaptation to environmental stresses and its utility as a model for studying adaptation mechanisms in amphibious plants.
Effect of GP visits in the compliance of preventive services: a cross-sectional study in Europe
Authors: Ares-Blanco Sara , López-Rodríguez Juan A. , Polentinos-Castro Elena , del Cura-González Isabel
Published: May 2024

Background

Performing cardiovascular and cancer screenings in target populations can reduce mortality. Visiting a General Practitioner (GP) once a year is related to an increased likelihood of preventive care. The aim of this study was to analyse the influence of visiting a GP in the last year on the delivery of preventive services based on sex and household income.

Methods

Cross-sectional study using data collected from the European Health Interview Survey 2013–2015 of individuals aged 40–74 years from 29 European countries. The variables included: sociodemographic factors (age, sex, and household income (HHI) quintiles [HHI 1: lowest income, HHI 5: more affluent]), lifestyle factors, comorbidities, and preventive care services (cardiometabolic, influenza vaccination, and cancer screening). Descriptive statistics, bivariate analyses and multilevel models (level 1: citizen, level 2: country) were performed.

Results

242,212 subjects were included, 53.7% were female. The proportion of subjects who received any cardiometabolic screening (92.4%) was greater than cancer screening (colorectal cancer: 44.1%, gynaecologic cancer: 40.0%) and influenza vaccination. Individuals who visited a GP in the last year were more prone to receive preventive care services (cardiometabolic screening: adjusted OR (aOR): 7.78, 95% CI: 7.43–8.15; colorectal screening aOR: 1.87, 95% CI: 1.80–1.95; mammography aOR: 1.76, 95% CI: 1.69–1.83 and Pap smear test: aOR: 1.89, 95% CI:1.85–1.94). Among those who visited a GP in the last year, the highest ratios of cardiometabolic screening and cancer screening benefited those who were more affluent. Women underwent more blood pressure measurements than men regardless of the HHI. Men were more likely to undergo influenza vaccination than women regardless of the HHI. The highest differences between countries were observed for influenza vaccination, with a median odds ratio (MOR) of 6.36 (under 65 years with comorbidities) and 4.30 (over 65 years with comorbidities), followed by colorectal cancer screening with an MOR of 2.26.

Conclusions

Greater adherence to preventive services was linked to individuals who had visited a GP at least once in the past year. Disparities were evident among those with lower household incomes who visited a GP. The most significant variability among countries was observed in influenza vaccination and colorectal cancer screening.
Sex difference in the associations among risk factors with gastroesophageal reflux disease in a large Taiwanese population study
Authors: Lin Chien-Chieh , Geng Jiun-Hung , Wu Pei-Yu , Huang Jiun-Chi , Hu Huang-Ming , Chen Szu-Chia , Kuo Chao-Hung
Published: May 2024

Background

Gastroesophageal reflux disease (GERD) is a common global health issue. Previous studies have revealed a higher prevalence of GERD in females than in males, however few studies have investigated sex differences in the risk factors associated with GERD. Therefore, the aim of this population-based study was to examine sex differences in the risk factors for GERD in a large cohort of over 120,000 Taiwanese participants.

Methods

We enrolled 121,583 participants (male: 43,698; female: 77,885; mean age 49.9 ± 11.0 years) from the Taiwan Biobank. The presence of GERD was ascertained using self-reported questionnaires. Sex differences in the risk factors associated with GERD were examined using multivariable logistic regression analysis.

Results

The overall prevalence of GERD was 13.7%, including 13.0% in the male participants and 14.1% in the female participants (p < 0.001). Multivariable analysis showed that older age, hypertension, smoking history, alcohol history, low fasting glucose, and low uric acid were significantly associated with GERD in the male participants. In the female participants, older age, diabetes, hypertension, smoking history, alcohol history, low systolic blood pressure, low fasting glucose, high hemoglobin, high total cholesterol, low high-density lipoprotein cholesterol (HDL-C), low low-density lipoprotein cholesterol, and low uric acid were significantly associated with GERD. Significant interactions were found between sex and age (p < 0.001), diabetes (p < 0.001), smoking history (p < 0.001), fasting glucose (p = 0.002), triglycerides (p = 0.001), HDL-C (p = 0.001), and estimated glomerular filtration rate (p = 0.002) on GERD.

Conclusions

Our results showed a higher prevalence of GERD among females compared to males. Furthermore, sex differences were identified in the risk factors associated with GERD, and older age, diabetes, smoking history, and low HDL-C were more closely related to GERD in females than in males.
The association between ultra-processed food and common pregnancy adverse outcomes: a dose-response systematic review and meta-analysis
Authors: Talebi Sepide , Mehrabani Sanaz , Ghoreishy Seyed Mojtaba , Wong Alexei , Moghaddam Aliasghar , Feyli Peyman Rahimi , Amirian Parsa , Zarpoosh Mahsa , Kermani Mohammad Ali Hojjati , Moradi Sajjad
Published: May 2024

Objectives

Given the increasing incidence of negative outcomes during pregnancy, our research team conducted a dose-response systematic review and meta-analysis to investigate the relationship between ultra-processed foods (UPFs) consumption and common adverse pregnancy outcomes including gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) infants. UPFs are described as formulations of food substances often modified by chemical processes and then assembled into ready-to-consume hyper-palatable food and drink products using flavors, colors, emulsifiers, and other cosmetic additives. Examples include savory snacks, reconstituted meat products, frozen meals that have already been made, and soft drinks.

Methods

A comprehensive search was performed using the Scopus, PubMed, and Web of Science databases up to December 2023. We pooled relative risk (RR) and 95% confidence intervals (CI) using a random-effects model.

Results

Our analysis (encompassing 54 studies with 552,686 individuals) revealed a significant association between UPFs intake and increased risks of GDM (RR = 1.19; 95% CI: 1.10, 1.27; I2 = 77.5%; p < 0.001; studies = 44; number of participants = 180,824), PE (RR = 1.28; 95% CI: 1.03, 1.59; I2 = 80.0%; p = 0.025; studies = 12; number of participants = 54,955), while no significant relationships were found for PTB, LBW and SGA infants. Importantly, a 100 g increment in UPFs intake was related to a 27% increase in GDM risk (RR = 1.27; 95% CI: 1.07, 1.51; I2 = 81.0%; p = 0.007; studies = 9; number of participants = 39,812). The non-linear dose-response analysis further indicated a positive, non-linear relationship between UPFs intake and GDM risk Pnonlinearity = 0.034, Pdose-response = 0.034), although no such relationship was observed for PE (Pnonlinearity = 0.696, Pdose-response = 0.812).

Conclusion

In summary, both prior to and during pregnancy, chronic and excessive intake of UPFs is associated with an increased risk of GDM and PE. However, further observational studies, particularly among diverse ethnic groups with precise UPFs consumption measurement tools, are imperative for a more comprehensive understanding.
The association between increased fetal movements in the third trimester and perinatal outcomes; a systematic review and meta-analysis
Authors: Hantoushzadeh Sedigheh , Gargari Omid Kohandel , Jamali Marzieh , Farrokh Fatemeh , Eshraghi Nasim , Asadi Fatemeh , Mirzamoradi Masoumeh , Razavi Seyed Jafar , Ghaemi Marjan , Aski Sudabeh Kazemi , Panhi Zahra , Habibi Gholam Reza
Published: May 2024

Background

Fetal movement monitoring is one of the strategies used to assess the fetus’s health. Until now, most studies focused on the decreased fetal movement and neonatal outcome, although this systematic review and meta-analysis is designed to assess the association between increased fetal movements (IFM) with perinatal outcomes.

Method

The electronic databases including PubMed, Scopus, Web of Science, and EMBASE were systematically searched for studies investigating the perinatal outcome of women with increased fetal movements from inception to July 2023. Following that, a random-effect meta-analysis model was used to obtain the combined diagnostic and predictive parameters including perinatal mortality (still birth and early neonatal mortality), operative delivery, Apgar score, neonatal resuscitation at birth and NICU Admission.

Results

After the initial screening, seven studies examining the association between increased third trimester fetal movement and various perinatal outcomes were included. Meta-analysis revealed a significant reduction in the risk of cesarean delivery among patients with IFM compared to controls, suggesting a potential protective effect during childbirth. However, no statistically significant difference was observed in birth weight, small or large for gestational age births, neonatal intensive care unit admission, maternal age, umbilical cord around the neck, gestational diabetes mellitus, and hypertension, indicating that IFM may not be a major predictor of adverse perinatal outcomes or maternal conditions. Notably, IFM was significantly associated with a higher likelihood of labor induction.

Conclusion

The findings suggest that IFM may have a protective effect against cesarean delivery. Additionally, IFM does not appear to be significantly associated with maternal age, umbilical cord around the neck, gestational diabetes mellitus and hypertension. However, the observed significant association with labor induction warrants further investigation.
Dietary supplement intake in women with breast cancer before and after diagnosis: results from the SUCCESS C trial
Authors: Hauner Dagmar , Mang Anna , Donik Lara , Schederecker Florian , Meyer Dorothy , Rack Brigitte , Janni Wolfgang , Hauner Hans
Published: May 2024

Background

There is little evidence that dietary supplements are beneficial for patients with breast cancer; therefore, they are usually not recommended by treatment guidelines. The aim of the present analysis was to assess the prevalence of dietary supplement (DS) intake among women before and after a breast cancer diagnosis.

Methods

Participants in the SUCCESS C lifestyle intervention study, a randomized controlled trial in women with newly diagnosed intermediate- to high-risk breast cancer, completed two questionnaires on dietary supplement intake 24 months (QS1) and 48 months (QS2) after beginning the lifestyle intervention. The study was registered on 12.17.2008 under the EU Clinical Trials Register https://www.clinicaltrialsregister.eu/, trial registration number: 2008-005453-38. The questionnaires collected data on DS intake during the 5-year period prediagnosis (QS1) and in the period postdiagnosis (QS2). Multivariate logistic regression models were fitted to examine differences in DS intake between the two intervention groups. The groups were then pooled to examine differences in DS use between the prediagnostic and postdiagnostic period.

Results

A total of 320 questionnaires from 58.5% of intervention group completers and 416 questionnaires from 46.6% of low-level intervention group completers were included in the analysis. Overall, 20.2% of all respondents reported taking DS prior to their diagnosis. After a cancer diagnosis, the percentage of women taking DS significantly increased to 56.4% (p for time effect < 0.0001). No differences in DS intake between the intervention groups were observed. Single or combined preparations of vitamins and minerals/trace elements were the most frequently reported supplements. Notably, a 9-fold increase in vitamin D intake was reported postdiagnosis, where the proportion of women increased from 3.8 to 34.5%.

Conclusion

A 3-fold increase in the reported intake of dietary supplements was seen in women after a breast cancer diagnosis. These observations underscore the need to incorporate patient education surrounding the use of dietary supplements in a treatment care plan, particularly addressing the negligible benefits as well as the potential risks and treatment interactions.
Facilitators and barriers of HPV vaccination: a qualitative study in rural Georgia
Authors: Petagna Courtney N. , Perez Stephen , Hsu Erica , Greene Brenda M. , Banner Ionie , Bednarczyk Robert A. , Escoffery Cam
Published: May 2024

Introduction

Human papillomavirus (HPV) vaccination protects against HPV-associated cancers and genital warts. Healthy People 2030 goal for HPV vaccine uptake is 80%, but as of 2021, only 58.5% of adolescents are up to date in Georgia. The purpose of the study is to assess the attitudes, vaccine practices, facilitators, and barriers to receiving the HPV vaccine in southwest Georgia.

Methods

We conducted 40 semi-structured interviews in the United States from May 2020-Feburary 2022 with three different audiences (young adults, parents, and providers and public health professionals) guided by the P3 (patient-, provider-, practice-levels) Model. The audiences were recruited by multiple methods including fliers, a community advisory board, Facebook ads, phone calls or emails to schools and health systems, and snowball sampling. Young adults and parents were interviewed to assess their perceived benefits, barriers, and susceptibility of the HPV vaccine. Providers and public health professionals were interviewed about facilitators and barriers of patients receiving the HPV vaccine in their communities. We used deductive coding approach using a structured codebook, two coders, analyses in MAXQDA, and matrices.

Results

Out of the 40 interviews: 10 young adults, 20 parents, and 10 providers and public health professionals were interviewed. Emerging facilitator themes to increase the uptake of the HPV vaccine included existing knowledge (patient level) and community outreach, providers’ approach to the HPV vaccine recommendations and use of educational materials in addition to counseling parents or young adults (provider level) and immunization reminders (practice level). Barrier themes were lack of knowledge around HPV and the HPV vaccine (patient level), need for strong provider recommendation and discussing the vaccine with patients (provider level), and limited patient reminders and health education information around HPV vaccination (practice level). Related to socio-ecology, the lack of transportation and culture of limited discussion about vaccination in rural communities and the lack of policies facilitating the uptake of the HPV vaccine (e.g., school mandates) were described as challenges.

Conclusion

These interviews revealed key themes around education, knowledge, importance of immunization reminders, and approaches to increasing the HPV vaccination in rural Georgia. This data can inform future interventions across all levels (patient, provider, practice, policy, etc.) to increase HPV vaccination rates in rural communities.
Neurodevelopmental outcomes following possible serious bacterial infection in early infancy in Karachi, Pakistan: a prospective cohort study
Authors: Farheen Nudrat , Shahid Shahira , Lalani Kiran Ramzan Ali , Azam Iqbal , Khalid Farah , Fatima Batool , Islam Mohammad Shahidul , Saha Samir K. , Qazi Shamim Ahmad , Jehan Fyezah , Nisar Muhammad Imran
Published: May 2024

Background

Pakistan reports a significant burden of neonatal mortality, with infections as one of the major causes. We aim to assess the long-term impact of early infancy infections on neurodevelopmental outcomes during later childhood.

Methods

We conducted a prospective follow-up study of the cohort enrolled at the Karachi site of the Aetiology of Neonatal Infection in South Asia (ANISA) during 2019–2020. Children with a possible serious bacterial infection (based on the WHO IMCI algorithm) at early infancy were assessed for neurodevelopment at 6–9 years of age and compared with healthy controls. The Ten Questions (TQS) questionnaire, Strengths and Difficulties Questionnaire (SDQ), and Parent’s Evaluation of Developmental Stage Assessment Level (PEDS: DM-AL) neurodevelopmental assessment tools, were administered and scored by the research staff who were blinded to the child’s exposure status. Generalized Structural Equation Modelling (GSEM) was employed to verify relationships and associations among developmental milestones, anthropometry, and sociodemographic variables.

Results

A total of 398 children (241 cases and 157 controls) completed neurodevelopmental and growth assessments. Cases had a significantly higher rate of abnormal TQS scores (54.5% vs. 35.0%, p-value 0.001), greater delays in motor milestones (21.2% vs. 12.1%, p-value 0.02), lower fine motor skills (78.4 ± 1.4 vs. 83.2 ± 1.5, p-value 0.02). The receptive language skills were well-developed in both groups. According to the logistic regression model, exposure to infection during the first 59 days of life was associated with delayed TQS milestones (β = -0.6, 95% CI -1.2,-0.04), TQS hearing domain (β = -0.3, 95% CI: -1.2 to 0.7), PEDS: DM-AL fine motor domain (β = -1.3, 95% CI: -4.4 to 1.7), PEDS: DM-AL receptive language development (β = -1.1, 95% CI: -3.7 to 1.4) and child anthropometric measurements such as weight and height (β = -0.2, 95% CI: -0.4 to 0.01 and β = -0.2, 95% CI: -0.4 to -0.01, respectively). Early pSBI exposure was positively associated with PEDS: DM-AL self-help domain (β = 0.6, 95% CI: -1.2 to 2.4) and SDQ-P overall score (β = 0.02, 95% CI: -0.3 to 0.3).

Conclusion

Children exposed to PSBI during early infancy have higher rates of abnormal development, motor delays, and lower fine motor skills during later childhood in Pakistan. Socioeconomic challenges and limited healthcare access contribute to these challenges, highlighting the need for long-term follow-ups with integrated neurodevelopment assessments.