bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Bio-Cement Reinforced with Eggshell Composites
Authors: Rosmamuhamadani R.
Published: May 2024

Eggshells are an interesting inorganic compound with a chemical composition and crystallographic structure similar to that of CaCO3. This study aims to acquire a better understanding of the use of eggshells, which are commercially incorporated into cement mixtures, to increase the mechanical strength of cement-eggshell composite. The cement mixture was prepared by incorporating different compositions (5, 10, and 15 wt.%) of eggshell powder. The raw eggshells were cleaned, crushed, dried, sieved into small pieces, and mixed with the cement according to the desired composition. Analysis of the eggshell powder showed similar peaks to CaCO3, indicating that eggshells can be used as a calcium source. The results indicated that the addition of 10 wt.% finely ground eggshell powder improved the compressive and flexural strength of the cement mix. It was also found that eggshell powder can potentially be used as a filler, as it exhibited the highest water absorption at 15 wt.%. The use of eggshells as a reinforcing component in environmentally friendly cement mixes has the potential to improve the environment by reducing waste, the need for conventional cement resources, and the pollution caused by excessive cement mining.
Analisis Peran Moderasi Perceived Value pada Hubungan antara Kepuasan Pengguna dan Niat Penggunaan E-wallet DANA
Authors: Santika Harfian Bunga , Jadmiko Purbo
Published: May 2024

Penggunaan dompet digital semakin meluas dalam perilaku konsumen saat ini. Penelitian ini bertujuan untuk memperoleh pemahaman mendalam dan menganalisis hubungan antara nilai yang dirasakan (perceived value) dan niat untuk terus menggunakan layanan Dana e-wallet di Kota Padang. Survei dilakukan dengan melibatkan 72 responden. Data yang dikumpulkan bersifat kuantitatif melalui teknik survei. Analisis data dilakukan menggunakan Moderated Regression Analysis (MRA). Temuan penelitian menunjukkan bahwa tingkat kepuasan pengguna terhadap nilai yang dirasakan secara positif berkorelasi dengan niat untuk terus menggunakan layanan, dan bahwa nilai yang dirasakan memiliki pengaruh yang signifikan terhadap niat pengguna untuk terus menggunakan Dana e-wallet di Kota Padang. Implikasi dari penelitian ini adalah pentingnya memperhatikan nilai yang dirasakan oleh pengguna dalam mengembangkan strategi pemasaran dan pengembangan layanan e-wallet, terutama di pasar Kota Padang yang berkembang pesat. Dengan memahami faktor-faktor yang mempengaruhi niat pengguna, perusahaan dapat meningkatkan retensi pelanggan dan kesetiaan merek dalam ekosistem dompet digital.
Exploring the influence of climate oscillations on groundwater: Review of observational studies
Authors:   Department of Civil and Environmental Engineering, School of Engineering, Universidad de las Américas Puebla, San Andrés Cholula, Puebla, Mexico, Guevara-Polo David-Eduardo , Patiño-Gomez Carlos ,   Department of Civil and Environmental Engineering, School of Engineering, Universidad de las Américas Puebla, San Andrés Cholula, Puebla, Mexico, Corona-Vasquez Benito ,   Department of Civil and Environmental Engineering, School of Engineering, Universidad de las Américas Puebla, San Andrés Cholula, Puebla, Mexico
Published: May 2024

Groundwater is critical for society’s adaptation to climate variability and change but simultaneously, is threatened by them. This paper reviews the linkages between climate oscillations and groundwater, focusing on studies reported in the Scopus database that use wavelet analysis. A total of 27 records published since 2009, covering North America, Europe, and Asia, have been analysed. El Niño Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), Arctic Oscillation, and the Pacific Decadal Oscillation (PDO) show important effects on groundwater levels in North America. In Europe, NAO is the most dominant, while in Asia, distinct climate indices impact groundwater levels at different periodicities. The hydrogeological features of the aquifers condition the magnitude of the response of groundwater to the climate signal and there is conflicting evidence concerning the effects of land-use change and human activities on detecting climate signals in aquifers. Further research must focus on understanding the effect of human activities in the climate signal perception in aquifers, unravelling the physical mechanisms underlying the propagation of climate signals through aquifers, developing predictive models to support water management decisions, and finding alternative methods to assess this influence in regions with limited observational data. The interaction between the atmosphere and groundwater is of critical relevance for the achievement of water security and this review contributes to synthesizing our current understanding of this relationship.
Concentración de fluoruros en aguas subterráneas de los Altos de Jalisco, México
Authors:   Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlán, Jalisco, México, Castañeda Villanueva Aldo Antonio
Published: May 2024

La principal fuente de abastecimiento de agua potable en la mayoría de las regiones administrativas del estado de Jalisco (México) son los acuíferos subterráneos, que en muchos casos son de origen hidrotermal, los cuales se caracterizan por la presencia de compuestos químicos potencialmente nocivos para la salud humana y animal. El área de estudio de este trabajo se ubica en el noreste del estado de Jalisco, comprendiendo 10 municipios en dos regiones administrativas. El presente estudio tiene como objetivo determinar la tendencia de la concentración de flúor en pozos profundos que abastecen de agua potable a los municipios del área de estudio, a partir de dos evaluaciones realizadas durante los años 2021 y 2022. En los resultados se puede observar una tendencia creciente en la concentración de flúor de la mayoría de los pozos analizados en los periodos estudiados, las mayores concentraciones se reportan en las localidades de: Tepatitlán, Arandas, Mexticacán y San Miguel el Alto, así como en los municipios de Valle de Guadalupe y Cañadas de Obregón, representando el uso de estas fuentes como agua potable un mayor riesgo para la salud de la población local, ratificándose así mismo, una tendencia creciente en la concentración de fluoruros en las aguas subterráneas extraídas del área de estudio, una posible causa es la continua disminución en el nivel dinámico de extracción que presentan la mayoría de los pozos evaluados. Es necesario implementar programas y estrategias para garantizar la sostenibilidad de este recurso vital en esta y otras regiones del país.
О ПРИЧИНАХ ВОЗНИКНОВЕНИЯ ХАЗАРСКОГО ГОРОДА В ДЕЛЬТЕ ВОЛГИ
Authors: Васильев Дмитрий Викторович
Published: May 2024

В статье рассматривается авторское видение причин возникновения города в дельте Волги в хазарское время. В качестве основной причины декларируется необходимость перевалки товаров с морских судов на речные в ходе торговли по Каспийско-Волжскому торговому пути. Прослеживается изменение маршрутов движения товаров по Волжскому пути в VIII– IX вв. (в обход дельты Волги) и в X в. (через дельту Волги) в связи с изменением начальной точки этих маршрутов – Дамаска в ранний период и Багдада в поздний. Второй причиной возникновения города в дельте Волги называется наличие здесь кочевой ставки хазарских каганов, название которой по-русски звучит как «Белая». Ассоциируя это название с цветовым обозначением стран света в тюркской культуре, автор предполагает, что изначально «Белая» или западная ставка как центр Хазарии соответствовала западной ставке Тюркского каганата. Тем самым декларируется политическая преемственность Хазарии по отношению к Тюркскому каганату. Высказывается предположение, что первоначальное местоположение «Белой» ставки соответствует окрестностям села Семибугры в центральной части дельты Волги, а превращение её в полноценный город археологически прослеживается на Самосдельском городище в западной части дельты, куда она была перенесена в X в. в результате трансгрессии Каспия.
Mining as a Sustainable Development: Social License vs. State license
Authors: Salas Obed Vargas , Curo Helen Mayte Cayte , Salinas María de los Angeles Aquije , López Ricardo Enrique Grundy
Published: May 2024

Objective: The purpose of this study is to investigate mining activity as a sustainable development, based on the social license and the state license, with the aim of systematizing literature on obtaining the license to operate.
 
Theoretical Framework: This topic presents the main concepts and theories that support the research. Thus, the Social License to Operate and social conflicts stand out, providing a solid basis for understanding the context of the research.
 
Method: The methodology includes the review of previous research indexed in the Scopus and Web of Science databases. To do this, search strings were applied, using the Boolean operators AND, OR and NOT and applying pre-established search and screening criteria.
 
Results and Discussion: The main finding of the research is that Social License to Operate must have effective communication between the community and the business sector, so that possible changes related to the needs of the interest groups involved are considered in the future.
 
Implications of the research: the practical and theoretical implications of this research are that the qualities of the Social License to Operate have the possibility of varying social relations as long as environmental issues are addressed by the private sector and by policies. public.
 
Originality/Value: It contributes to the literature by showing that the Social License to Operate is gaining importance in scientific research, so that researchers open academic debate.
Advertising as An Influencing Factor on Consumer Behavior
Authors: Farooq Samiya , Maqbool Adeel
Published: May 2024

Objectives: The objective of this study is to examine the role of advertising as a management strategy in contemporary business environments. It aims to explore how advertising interacts with customers and influences both internal and external organizational processes and activities. Additionally, the study seeks to address misconceptions surrounding advertising's purpose and societal impact, particularly regarding its perceived manipulation of consumers for monetary gain.
 
Methods: This study employs a qualitative approach to investigate the role of advertising in modern business practices. It involves a comprehensive review of literature and existing research to analyze the relationship between advertising, consumer behavior, and organizational management strategies.
 
Results: The analysis reveals that advertising serves as a crucial management tool for businesses, facilitating interaction with customers and driving organizational processes. Contrary to misconceptions, advertising is not solely aimed at manipulating consumers for profit but also serves to fulfill customer needs for information about brands, services, and products. Additionally, the study finds that factors such as age, income, and satisfaction with promoted goods after purchase do not significantly influence the impact of advertisements on consumer purchasing decisions.
 
Conclusion: In conclusion, advertising plays a multifaceted role in contemporary business environments, serving as both a communication tool and a management strategy. While it is often misunderstood and criticized for its perceived manipulative nature, advertising remains a fundamental aspect of modern marketing practices. By understanding the complexities of advertising's influence on consumer behavior, businesses can develop more effective marketing strategies and better serve their customers' needs.
National Economic Stimulus Policy to Reduce Non-Performing Loan Risk on Msme Debtors Affected by Covid-19 Disturbing Banking Performance and National Financial System
Authors: Zubaedah Rahmi , Zarkasyi Wahyudin , Hilmi Indah Laily
Published: May 2024

Purpose: This study aims to analyze the effectiveness of stimulus policies implemented by The Financial Services Authority (OJK) in response to the current pandemic, specifically in aiding MSME debtors impacted by Covid-19 and mitigating the occurrence of bad credit.
 
Method: The research adopts a normative approach combined with both statutory and empirical juridical methodologies to examine the implementation of stimulus policies by OJK, particularly focusing on the provisions outlined in POJK Number: 11/POJK.03/2020.
 
Results and conclusion: The findings reveal that the economic stimulus policy introduced by the government has the potential to assist MSME debtors adversely affected by Covid-19 and alleviate the burden of bad loans. The extension of credit restructuring until March 2022 provided by this policy is identified as a key factor in facilitating increased lending activities and fostering accelerated national economic growth.
 
Research implications: This study contributes to the understanding of the efficacy of stimulus measures in addressing economic challenges posed by the pandemic, particularly in the context of MSMEs. It underscores the importance of timely and targeted interventions in supporting vulnerable sectors and safeguarding financial stability.
 
Originality/value: By combining normative and empirical juridical approaches, this research offers a comprehensive analysis of the implementation of stimulus policies by OJK and their impact on MSME debtors. The identification of specific provisions, such as credit restructuring extensions, provides valuable insights for policymakers, financial regulators, and stakeholders involved in formulating effective economic recovery strategies.
Asbab Al-Wurud as an Approach to Understanding the Purpose of Hadith (Maqasid Al-Sunnah) in a Wasatiyyah and Balanced Way that is Practiced in Contemporary Society
Authors: Masruri Muhammad , Sahimi Mohd Shafiq , Karim Abdul , Ahmad Shakila binti
Published: May 2024

Objective: The understanding and implementation of the Hadith, as the second main source in Islam, should align with the intended purpose and message delivered by the Hadith to its audience. To preserve the peace of humanity, one of these qualities involves being balanced, moderate, and not extreme. Currently, there are still a significant number of Muslims who excessively adhere to the Hadith of the Prophet, exhibit harsh behavior from a liberal perspective, or solely rely on logical reasoning.
 
Theoretical framework: This article seeks to elucidate the application of maqasid al-Sunnah in the interpretation of the Hadith of the Prophet SAW, employing the methodologies established by renowned scholars as well as the method of asbab al-wurud in a balanced and moderate manner.
 
Method: This article uses content analysis to examine discussions on the method of asbab al-wurud as an approach to maqasid al-sunnah. This method is used to interpret hadith in a comprehensive and balanced way.
 
Results and Discussion: Attaining equilibrium and unity in life is one of the primary objectives of the observance of the Hadith of the Prophet. To achieve this objective, it is necessary to comprehend the Nabawi Hadith in a straightforward and equitable manner, aligning with its intended purpose and objective. The understanding and interpretation of a hadith, as well as its transmission to the listener, can be obtained by consulting the scholarly opinions of the Salf al-Salih and considering the asbab al-Wurud.
 
Conclusion: The concept of maqasid al-sunnah, when understood through the lens of the ultimate hadith and the application of the method of asbab al-wurud, allows for a more comprehensive and balanced comprehension of a hadith. This approach ensures that the hadith is interpreted in a manner that is in line with the conditions of the current times and places, and is accepted by all Muslims. This strategy enables the effective management and regulation of extreme, excessively literal, and radical comprehension, resulting in the attainment of peace and well-being for all of humanity.
Contrast-induced encephalopathy with acute stroke symptomatic: a case report
Authors: Corona Andrea , Zehnder Joanna Meret , Kajdi-Schwab Marie-Elisabeth , Meyer Matthias , Caporale Christina Michaela , Sardo Salvatore , Porta Francesca Margherita
Published: May 2024

Background:

Contrast-induced encephalopathy (CIE) is an infrequent complication of contrast media administration. It is usually transient but occasionally leads to permanent neurological deficits and death.

Case Presentation:

We report here a case of nonionic iodized CIE after an urgent coronary angiography, in a 62-year-old woman who developed symptoms of acute stroke. Although diagnostic challenge and under not specific but supportive therapy the symptoms resolved completely within 72 hours without further complications.

Conclusion:

CIE is a rare entity whose frequency is dependent on the increasing use of diagnostic/interventional procedures with contrast media. The exclusion of more common complications of such procedures should be prompt. The clinical scenario is challenging and should be considered, in particular in high-risk patients. The course is generally benign and requires supportive therapy.
A case report on Creutzfeldt-Jacob disease: early diagnosis through multidisciplinary lens
Authors: Parvin Hena , Dutta Anwesha , Hazra Subhrajit
Published: May 2024

Background:

Creutzfeldt Jacob disease is a rapidly progressive neurodegenerative disorder, which is invariably fatal and results in death within 1 year of onset. The patient presents with a variety of non-specific neuropsychiatric symptoms, such as myoclonus, cerebellar symptoms, visual impairment, and behavioral abnormalities. The symptoms are rapidly progressive and cause early functional impairment in the patient.

Case Presentation:

In this report, we discussed a case of 49-year-old male presented with multiple neuropsychiatric symptoms. After a series of extensive diagnostic examinations and follow-up, the patient was diagnosed as having probable sporadic Creutzfeldt-Jakob disease based on 2018 Centres for Disease Control and Prevention criteria, with key findings of myoclonus, behavioral and cerebellar problems, visual abnormalities, abnormal hyperintensity signals on diffusion-weighted magnetic resonance imaging and characteristic electroencephalogram waves. CSF 14-3-3 protein was significantly high.

Conclusion:

Sporadic CJD is a rare and fatal rapidly progressive neurodegenerative disorder, that claims prompt and precise diagnosis to help clinicians distinguish it from potentially treatable neuropsychiatric disorders. This aspect elevates the significance of our report, as it aids not only the medical professionals but also the affected families. Early diagnosis enables the family to prepare for the disease course and appropriate management strategies.
The Exploration of Age Related Mirna in Saliva Based On Massively Parellel Sequencing: A Pilot Study
Authors:   School Of Basic And Clinical Medicine, Fang Chen
Published: May 2024

Age determination is one of the key components of forensic science research.
A Comparison of Enhancement and Visualization Techniques of Friction Ridge Bloodstain Patterns on Various Textiles
Authors:   Staffordshire University, School Of Justice, Security And Sustainability College, Kowalske Zack
Published: May 2024

This study investigates the feasibility of observing identifiable friction ridge patterns within a blood medium on common clothing textiles
Educación Somática y experiencia creativa. El títere de Moshé Feldenkrais
Authors: Macías Ordóñez Sylvia , Martínez Contreras Rayénari
Published: May 2024

El ensayo esboza los rasgos más relevantes de la vida de Moshé Feldenkrais para explicar, a partir de un contexto histórico y biográfico, en qué consiste su legado, cómo se inscribe dentro del campo de la Educación Somática y cómo se ha relacionado con las artes escénicas. En la segunda parte, nos centramos en el trabajo con títeres de la compañía Teatro Rodante; en específico, en el títere que representa al creador del Método Feldenkrais. Abordamos el proceso creativo de esta obra en pequeño formato, así como su difusión videográfica, el significado que tiene este producto artístico para la comunidad de practicantes de dicho método en México y más allá, así como su valor como medio de divulgación entre el público en general.
Somatic Education and creative experience. The case of Moshe Feldenkrais’ puppetAbstractThe essay outlines relevant features of Moshe Feldenkrais’ life in order to discuss his legacy within the field of Somatic Education, and how it relates to the performing arts. Focusing on the puppet work of the Teatro Rodante company, we describe a small-format piece in which the main character is the creator of the Feldenkrais Method. We discuss the relevance of this case study for the community of Feldenkrais practitioners in Mexico and elsewhere, and its value as a way of reaching a wider audience by means of a video broadcast.
Recibido: 23 de agosto 2023Aceptado: 29 de noviembre de 2023
Analisis Tantangan dan Peluang Perkembangan Globalisasi Ekonomi dalam Hukum Bisnis Di Indonesia
Authors: Hasibuan Nelson , Hasiholan Sihaloho  , Subhan Zein  , Mario Alberto Manodohon
Published: May 2024

Globalisasi sebagai pertumbuhan cepat yang saling ketergantungan dan koneksi di dunia perdagangan dan keuangan. Globalisasi tidak hanya terbatas pada fenomena perdagangan dan aliran keuangan yang berkembang dengan kian meluas saja, ini karena adanya kecenderungan lain yang didorong komunikasi. Bagaimana
tantangan dan peluang perkembangan globalisasi ekonomi dalam hukum bisnis di Indonesia? 1) Regulasi persaingan usaha, hukum bisnis mengatur persaingan usaha yang adil dan melarang praktik bisnis yang merugikan konsumen atau pesaing. Ini memastikan bahwa pasar tetap sehat dan mencegah monopoli yang merugikan ekonomi. Kontrak dan hukum kontrak. 2) Hukum bisnis mengatur pembuatan, interpretasi, dan penegakan kontrak. Ini memberikan kepastian hukum bagi pihak yang terlibat dalam transaksi bisnis dan memungkinkan kontraktor untuk mengandalkan pemenuhan kontrak. 3) Pengaturan perbankan dan keuangan, pengaturan dan pengawasan terhadap keseluruhan kegiatan keuangan tersebut harus dilakukan secara berintegritas. 4) Perlindungan Hak Kekayaan Intelektual (HKI).
Hukum bisnis melindungi hak cipta, paten, merek dagang, dan desain industri yang mendorong inovasi dan penciptaan barang dan jasa baru. Ini memberikan insentif kepada perusahaan dan individu untuk berinvestasi dalam penelitian dan pengembangan.
PEMIDANAAN TERHADAP PELAKU TINDAK PIDANA PEMALSUAN KARTU KREDIT (STUDI PUTUSAN No.345/PID.SUS/2021/PNY-YK)
Authors: Setiawan R Andhika Prameswara , Ganarsih Yenti
Published: May 2024

The crime of credit card forgery committed by Faisal Umar Firmansyah Bin Farid Firmansyah, namely  the act of buying another person's CC (Credit Card) without the knowledge of the owner at a price of IDR 80,000 per credit card and purchasing 9 (nine) cellphones by checking whether registered in the KLARNA application and if registered and have a balance then the purchase will continue and if there is no balance in the KLARNA application then fill it in advance for every $1000 USA at a price of IDR 3,000,000 to IDR 5,000,000 .Research with Decision Study No.345/Pid.sus/2021/Pn.Yyk. and there is a formulation of the problem: 1. Is the court's decision against the convict's actions Credit Card Counterfeiting according to Ps. 32 paragraph (1) jo. Ps 48 paragraph (1) Law no. 19 of 2016 concerning Amendments to Law no. 11 of 2008 concerning Electronic Information and Transactions? This study uses a normative research type that is descriptive analytical, using literature or secondary data which consists of primary legal materials and secondary legal materials obtained from literature studies and analyzed qualitatively using deductive logic, as well as drawing conclusions. The conclusions from this study are that 1. The Court's decision given to the Defendant of the Crime of Credit Card Counterfeiting is not appropriate based on Article 32 paragraph (1) jo. Ps 48 paragraph (1) Law no. 19 of 2016 concerning Amendments to Law no. 11 of 2008 concerning Information and Electronic Transactions, and 2. Judge's Decision No. 345/Pid.Sus/2021/PN Yyk which imposes a criminal sanction of 6 (six) months in prison is not in accordance with the purpose of sentencing.
An Unusual Case Report of Cotard’s Syndrome with Depressive Delusions
Authors: Das Amlan , Ghosh Soumitra , Bora Kavery
Published: May 2024

Cotard’s Syndrome, also known as nihilistic delusion or Cotard’s delusion, is an exceptionally rare psychiatric condition characterized by delusional beliefs ranging from a sense of being dead to the conviction of bodily decay or nonexistence. This case report of a male patient, aged 21 years, with Cotard’s Syndrome highlights the difficulties in diagnosis, the course of therapy, and the clinical ramifications of this illness. The patient exhibited symptoms of severe depression along with nihilistic delusions, expressing the belief that he was deceased and experiencing bodily decay. Nihilistic delusions and depressed symptoms compatible with Cotard’s syndrome in the setting of major depressive disorder were found during the patient’s mental state evaluation, despite the absence of a serious physical disease or drug addiction. Treatment consisted of antidepressant and antipsychotic medication, along with individual psychotherapy sessions focusing on cognitive restructuring. Over time, the patient demonstrated gradual improvement in delusional beliefs and depressive symptoms, highlighting the importance of comprehensive psychiatric evaluation and individualized treatment planning.
Advocacy for neonates: Will respiratory syncytial virus monoclonal antibodies and maternal vaccine be made available in India?
Authors: Varikkottil Mohamed Muneer , Ajith Divya , Pournami Femitha , Prabhakar Jyothi , Jain Naveen
Published: May 2024

Respiratory syncytial virus (RSV)-related morbidity in children has been widely described. Research has led to the availability of palivizumab for decades in high-income countries. Ongoing research underlines the high priority given to this conundrum. Nirsevimab, a long-acting monoclonal antibody, and a maternal vaccine have been developed and approved for RSV. Neither of these are available in India. Improving the survival of extreme preterm neonates in our country should parallel other strategies to protect them from diseases that affect these high-risk neonates. This case series comprises sick RSV-infected infants from our centre over a single season. Of 187 young infants who presented to the Neonatology Department with features of viral lower respiratory infections, 9 (4.8%) required intensive care. All of them were positive for RSV by nasopharyngeal polymerase chain reaction. A total of 25 (13%) required hospitalisation. Preterm infants presented with apnea or severe respiratory distress. All 9 in the intensive care unit required respiratory support, and 8 needed invasive ventilation. The median duration of hospital stay for these infants was 18 (7–37) days. This report is an appeal to stakeholders towards making these evidence-based prophylactic methods available in India. A preventable problem in high-risk neonates could be reduced. Improving neonatal survival and outcomes calls for our country to be at par with high-income countries for RSV prevention. RSV-related morbidity is an endemic conundrum with a high disease burden. We could take prompt action, akin to efforts taken during the COVID-19 pandemic.
T-Shaped Nickel Metalloradical Bearing a Phenalenyl-Based Tridentate Ligand
Authors: Noguchi Hikaru , Kodama Takuya , Kikkawa Soichi , Yamazoe Seiji , Tobisu Mamoru
Published: May 2024

A T-shaped nickel(I) complex 1 bearing a phenalenyl-based tridentate ligand was synthesized. The electronic and spin struc-tures of 1 were elucidated through electronic absorption spectra, ESR, and XAFS measurements. Additionally, the metallo-radical reactivity of 1 toward diphenyl disulfide and alkyl halides was also demonstrated.
GlyCombo enables rapid, complete glycan composition identification across diverse glycomic sample types
Authors: Kelly Maia I , Ashwood Christopher
Published: May 2024

Glycans are sugar-based polymers found to modify biomolecules including lipids and proteins, as well as occur unconjugated as free polysaccharides. Due to their ubiquitous cellular presentation, glycans mediate crucial biological processes and are frequently sought after as biomarkers for a wide range of diseases. Identification of glycans present in samples acquired with mass spectrometry (MS) is a cornerstone of glycomics research, thus, the ability to rapidly identify glycans in each acquisition is integral to glycomics analysis pipelines. Here we introduce GlyCombo (https://github.com/Protea-Glycosciences/GlyCombo), an open-source, freely available software tool designed to rapidly assign monosaccharide combinations to observed and fragmented precursors in an MS experiment. GlyCombo was evaluated across six diverse datasets, demonstrating MS vendor, derivatization, and glycan-type neutrality. Compositional assignments using GlyCombo are shown to be faster than the current, predominant approach, GlycoMod, a closed-source web application. Finally, the comprehensiveness of glycan feature identification is exhibited in Skyline, a software that requires pre-defined transitions that are derived from GlyCombo output files.
Characterization of Monoclonal Antibody Charge Variants under Near-Native Separation Conditions using Nanoflow Sheath Liquid Capillary Electrophoresis-Mass Spectrometry
Authors: van der Zon Annika A.M. , Höchsmann Alisa , Bos Tijmen S. , Neusüß Christian , Somsen Govert W. , Jooß Kevin , Haselberg Rob , Gargano Andrea F.G.
Published: May 2024

Monoclonal antibodies (mAbs) undergo multiple post-translational modifications (PTMs), e.g., charge variants, oxidation, etc., during production and storage, necessitating evaluation of the resulting PTMs as critical quality attributes (CQA) for protein quality and safety. Charge variants PTMs can be separated using capillary zone electrophoresis (CZE). The CZE EACA method developed by He et al. (2011) with UV detection is applied routinely in the pharmaceutical industry for analyzing charge variants. However, the method cannot be directly hyphenated with mass spectrometry (MS), preventing direct identification of separated charge variants due to the non-volatile background electrolyte (BGE), which hinders reliable charge variant identification. This study presents a CZE-UV/MS method using a neutral static capillary coating of hydroxypropyl methylcellulose combined with a volatile BGE at pH 5.0 to allow MS-compatible mAb charge variant separations. The effect of several parameters, including pH and concentration of BGE, voltage, and injected mAb concentrations in terms of separation performance on a panel of mAbs was investigated. The final method was tested with mAbs of IgG subclasses (IgG1 and IgG4) with different pI (7.4-9.2), and degrees of heterogeneity. Basic and acidic variants were separated from the parent mAb using a BGE of 50 mM acetic acid adjusted at pH 5.0. A linear correlation in relative charge variant abundance was obtained between our method and the EACA method. CZE-MS coupling was done using the nanoCEasy, a low-flow sheath liquid interface, and allowed the identification and quantitation of various low-abundance variants (<10% relative abundance with respect to the main compound). This method uses volatile buffers and operates at pH closer to non-denaturing conditions (pH 5.0), allowing for flexibility in hyphenation with MS. This method can be a useful tool for in-depth charge variants characterization of mAbs.
Fueling from the Electrochemistry of Halide Solid Electrolytes
Authors: Stamenkovic Branimir , Meng Ying Shirley , Moreau Philippe , GAUBICHER Joel
Published: May 2024

Unveiling the electrochemistry of solid-state Li2ZrCl6 halide electrolyte, we reveal its dual function as both an ion conductor and a supplementary electron source/sink. This groundbreaking discovery leads to a remarkable long-term enhancement of the specific capacity of industry-relevant heavily loaded LiFePO4 electrodes by several tens of percent, while significantly amplifying that of Si-based or anode-less full cells through effective compensation for side reactions. We show that these effects can potentially be tuned by adjusting the initial xLiCl-ZrCl4 composition of the solid electrolyte (SE), which may thus become a new and mighty parameter for balancing the two electrodes.
The Influence of Electron Donors on the Charge Transfer Dynamics of Carbon Nanodots in Photocatalytic Systems
Authors: Macpherson Stuart , Lawson Takashi , Abfalterer Anna , Andrich Paolo , Lage Ava , Reisner Erwin , Euser Tijmen , Stranks Samuel , Gentleman Alexander
Published: May 2024

Carbon nanodots are nanosized light-harvesters emerging as sustainable next-generation photosensitizers in photocatalytic reactions. Despite their ever-increasing potential applications, the intricate details underlying their photoexcited charge carrier dynamics are yet to be elucidated. In this study, nitrogen-doped graphitic carbon nanodots (NgCNDs) are selectively excited in the presence of methyl viologen (MV2+, redox mediator) and different electron donors, namely ascorbic acid (AA) and ethylenediaminetetraacetic acid (EDTA). The consequent formation of the methyl viologen radical cation (MV·+) is investigated, and the excited charge carrier dynamics of the photocatalytic system are understood on a 0.1 ps to 1 ms time range, providing spectroscopic evidence of oxidative or reductive quenching mechanisms experienced by optically excited NgCNDs (NgCNDs*) depending on the electron donor implemented. In the presence of AA, NgCNDs* undergo oxidative quenching by MV2+ to form MV·+, but is short-lived due to dehydroascorbic acid, a product of photoinduced hole quenching of oxidized NgCNDs. The EDTA-mediated reductive quenching of NgCNDs* is observed to be at least two orders of magnitude slower due to screening by EDTA-MV2+ complexes, but the MV·+ population is stable due to the irreversibly oxidized EDTA preventing a back reaction. In general, our methodology provides a distinct solution with which to study charge transfer dynamics in photocatalytic systems on an extended time range spanning 10 orders of magnitude. This approach generates a mechanistic understanding to select and develop suitable electron donors to promote photocatalytic reactions.
Systems genetics analysis of human body fat distribution genes identifies adipocyte processes
Authors: Reed Jordan N , Huang Jiansheng , Li Yong , Ma Lijiang , Banka Dhanush , Wabitsch Martin , Wang Tianfang , Ding Wen , Björkegren Johan LM , Civelek Mete
Published: May 2024

Excess abdominal fat is a sexually dimorphic risk factor for cardio-metabolic disease and is approximated by the waist-to-hip ratio adjusted for body mass index (WHRadjBMI). Whereas this trait is highly heritable, few causal genes are known. We aimed to identify novel drivers of WHRadjBMIusing systems genetics. We used two independent cohorts of adipose tissue gene expression and constructed sex- and depot-specific Bayesian networks to model gene-gene interactions from 8,492 genes. Using key driver analysis, we identified genes that, in silico and putatively in vitro, regulate many others. 51–119 key drivers in each network were replicated in both cohorts. In other cell types, 23 of these genes are found in crucial adipocyte pathways: Wnt signaling or mitochondrial function. We overexpressed or down-regulated seven key driver genes in human subcutaneous pre-adipocytes. Key driver genesANAPC2andRSPO1inhibited adipogenesis, whereasPSME3increased adipogenesis.RSPO1increased Wnt signaling activity. In differentiated adipocytes, MIGA1 and UBR1 down-regulation led to mitochondrial dysfunction. These five genes regulate adipocyte function, and we hypothesize that they regulate fat distribution.
Investigating the effect of instruction designed according to the ARCS model enriched with web 2.0 tools on students' mathematics achievement and motivation
Authors: Huriye Yavuzkan , Tušba Yelken , Figen Kiliç
Published: May 2024

This study aimed to investigate the effect of instruction designed according to the ARCS model enriched with Web 2.0 tools on the mathematics achievement and motivation of secondary school students and to examine student opinions regarding the applied instruction process. A mixed-methods approach was employed in the study since both quantitative and qualitative data were collected. To support quantitative data with qualitative data, a sequential explanatory design was chosen from mixed-methods designs. The research was conducted in the 2022–2023 academic year with the participation of 40 7th grade students enrolled in a public school in Niğde province. The research process was planned for 10 weeks, including a pretest administration in the first week, an eight-week intervention, and a posttest administration in the last week. In the experimental group, a mathematics instruction plan designed according to the ARCS model enriched with Web 2.0 tools was implemented, while in the control group, only the existing mathematics instruction plan was implemented. Quantitative data were collected using the ratio, proportion and percentage achievement tests and the mathematics motivation scale. Qualitative data were collected through focus group interviews with experimental group students. Data analysis was conducted, which included independent samples t-tests, paired samples t-tests, MANOVAs, and content analysis. The findings obtained from this study revealed that teaching with the ARCS model enriched with Web 2.0 tools had a positive effect on students' academic achievement. When the sub-dimensions of motivation were analyzed, no significant difference was found between the groups in the posttest motivation scores, but most of the participant students in the focus group interviews expressed positive opinions about the process and mentioned the effectiveness of the process. This study provides important information about the effectiveness of integrating Web 2.0 tools into the ARCS model in secondary school mathematics education in terms of the effectiveness of the teaching process and its contributions to students' achievement.
Chemical and sensory evaluations of energy bar made from purple sweet
potatoes and tapioca flour with the addition of Sidempuan salak
(Salacca sumatrana (Becc.)) fruit
Authors: Siregar N.S. , Julianti E. , Silalahi J. , Sinaga H.
Published: May 2024

Sidempuan salak is a local fruit originating from South Tapanuli, North Sumatra. This
fruit has a unique taste of sweet, sour and slightly astringent. This fruit can be consumed
fresh or processed into several products, such as flour, drinks and sweets. This study
aimed to develop a food-based energy bar from Sidempuan salak fruit (Salacca sumatrana
(Becc.)). Energy bar formulation was done by blending purple sweet potato flour, tapioca
flour, glucose syrup, egg albumen, coconut oil, salt, and dried salak fruit powder at 0 g as
the control, 100 g (bar 1), 150 g (bar 2) and 200 g (bar 3). The chemical characteristic
analysis showed that the control energy bars (CEB) per 100 g consisted of 63.17 g of
carbohydrates, 1.95 g of protein, 13.42 g of fat, 6.40 mg of vitamin C, 248.05 mg of
potassium and 381.24 kcal. Energy bar salak 1 (EBS1) had 377.44 kcal with a
composition of 68.34 g carbohydrates, 1.71 g protein, 10.81 g fat, 8.00 mg vitamin C and
347.05 mg potassium. Energy bar salak 2 (EBS2) contained 375.49 kcal with 71.48 g
carbohydrate, 1.84 g protein, 9.12 g fat, 5.77 mg vitamin C and 368.42 mg potassium.
Energy bar salak 3 (EBS3) showed 369.40 kcal with 74.54 g carbohydrates, 1.92 g
protein, 7.07 g fat, 9.96 mg vitamin C and 410.24 mg potassium. Based on sensory
evaluation, the untrained panellists indicated that ESB3 was the most preferred, even
though EBS1 and EBS2 were also very much acceptable. In conclusion, energy bars
containing salak (EBS1, EBS2, EBS3) were lower in calories than the control energy bars
due to the lower addition of flour. From the data obtained, salak has a good potential to be
used as an additional ingredient to develop energy bars.
Purchasing Behaviour and Trends of Cash and Carry Customers in District Bagh, Azad Jammu and Kashmir
Authors: Munsab Safia , Anwar Muhammad Masood , Fatima Gulzar
Published: May 2024

Purpose: Consumer behavior is much broad and complex concept in Economics. Not only income but other factors shape the consumption pattern in different regions, countries and even in cities. The main objective of this research is to identify and analyze the factors that influence purchasing behavior of cash and carry consumers during purchasing
Design/Methodology/Approach: This study uses different variables as independent variables and purchasing behavior as dependent variables also some intermediate variables that influences purchasing behavior of people. The sample is collecting and analyzing of 200 respondents in the city of District Bagh Azad Kashmir. Convenient Sampling technique uses to collect data and Statistical Package for Social Sciences (SPSS) is use for analysis. Reliability Analysis and Regression Analysis (RA) are use for analysis and hypothesis testing.
Findings: According to results people change their behaviour moderately during purchasing, A numbers of customer purchase according to environment, Facilities, advertisement, distance and awareness. However some customer purchase only planned products. This study concludes that some variables including in the study have significant and positive impact and some have negative impact on purchasing behavior. A small number of variables have insignificant relationship with purchasing behavior. Researcher only mentions significant variables.
Implications/Originality/Value: So it is concluded that seller behavior, packing, Geography, store environment and brands change the plan purchasing of consumer
Phase relations between Na3Nd(BO3)2, Na3Nd2(BO3)3, NdBO3 and their luminescence properties
Authors: Kuznetsov A.B. , Jamous A.Y. , Svetlichnyi V.A. , Kokh K.A.
Published: May 2024

The Na3Nd(BO3)2-NdBO3 phase diagram was investigated by the solid-state synthesis and DSC methods. Na3Nd(BO3)2, Na3Nd2(BO3)3 and NdBO3 were grown by spontaneous crystallization from the Na2O- B2O3-NaF flux. Typical Nd3+ luminescence of 4F3/2  4I9/2 and 4F3/24I11/2 electron transitions at 875 nm and 1054 nm were registered. Maximum integral intensity of the luminescence was observed for Na3Nd2(BO3)3 crystals, more than twice that of NdBO3, Na3Nd(BO3)2.
A combined cross-sectional analysis and case-control study evaluating tick-borne encephalitis vaccination coverage, disease and vaccine effectiveness in children and adolescents, Switzerland, 2005 to 2022
Authors: Zens Kyra D , Altpeter Ekkehardt , Wymann Monica N , Mack Annora , Baer Nora B , Haile Sarah R , Steffen Robert , Fehr Jan S , Lang Phung
Published: May 2024

Background

Tick-borne encephalitis (TBE) is a severe, vaccine-preventable viral infection of the central nervous system. Symptoms are generally milder in children and adolescents than in adults, though severe disease does occur. A better understanding of the disease burden and duration of vaccine-mediated protection is important for vaccination recommendations.

Aim

To estimate TBE vaccination coverage, disease severity and vaccine effectiveness (VE) among individuals aged 0–17 years in Switzerland.

Methods

Vaccination coverage between 2005 and 2022 was estimated using the Swiss National Vaccination Coverage Survey (SNVCS), a nationwide, repeated cross-sectional study assessing vaccine uptake. Incidence and severity of TBE between 2005 and 2022 were determined using data from the Swiss disease surveillance system and VE was calculated using a case–control analysis, matching TBE cases with SNVCS controls.

Results

Over the study period, vaccination coverage increased substantially, from 4.8% (95% confidence interval (CI): 4.1–5.5%) to 50.1% (95% CI: 48.3–52.0%). Reported clinical symptoms in TBE cases were similar irrespective of age. Neurological involvement was less likely in incompletely (1–2 doses) and completely (≥ 3 doses) vaccinated cases compared with unvaccinated ones. For incomplete vaccination, VE was 66.2% (95% CI: 42.3–80.2), whereas VE for complete vaccination was 90.8% (95% CI: 87.7–96.4). Vaccine effectiveness remained high, 83.9% (95% CI: 69.0–91.7) up to 10 years since last vaccination.

Conclusions

Even children younger than 5 years can experience severe TBE. Incomplete and complete vaccination protect against neurological manifestations of the disease. Complete vaccination offers durable protection up to 10 years against TBE.
The Leader of Public Opinion in the Conditions of Full-Scale War (on the Example of Masha Efrosinina)
Authors: Afanasiev Illia , Arutiunian Anastaciia
Published: May 2024

This article examines changes in the behavior of Ukrainian TV presenter Masha Efrosinina associated with the Russian-Ukrainian war. Before the full-scale war, Masha Efrosinina was known as a positive, optimistic, and kindhearted personality. She often spoke about happiness and well-being, engaged in charity, and supported women. During the war, Efrosinina’s behavior changed drastically. This influencer became more emotional, often expressing anger, aggression, and outrage. She did not shy away from expressing her position on the war and called on Russian citizens to take to the streets to protest putin’s anti-Ukrainian aggression. The authors of the article explain Efrosinina’s change in behavior as a result of the traumatic wartime events. The war caused her severe stress, which led to changes in her emotional and psychological state and behavior. In addition, the authors of the article argue that the war significantly strengthened Efrosinina’s leadership qualities. The TV presenter became a public activist and the initiator of many charitable projects. In this way, the article traces the impact of traumatic wartime events on the personality and public behavior of media personalities, creating new qualities and opportunities to influence public opinion.
PENGARUH KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA
Authors: Pramuswara Novita Andika , Haerudin Haerudin
Published: May 2024

The purpose of this research is to assess the extent to which students' understanding of mathematical concepts influences their ability to solve mathematical problems. This study was conducted at one of the junior high schools (SMPN) in Karawang Regency, using a quantitative approach and non-experimental method. The research subjects involved 34 students from class VII A, selected using purposive sampling technique. Data collection was carried out through two test instruments consisting of a set of descriptive questions covering indicators of both mathematical conceptual understanding and mathematical problem-solving skills. Simple linear regression analysis was employed in data processing for this research. The results obtained indicate, at a 95% confidence level, a significant influence of mathematical conceptual understanding on mathematical problem-solving abilities.