bluuebunny/crossref_metadata_2025 huggingface dataset:
When COVID-19 Enters in a Community Setting: An Exploratory Qualitative Study of Community Perspectives on COVID-19 Affecting Mental Well-Being
Authors: Ali Naureen Akber , Feroz Anam Shahil , Ali Noshaba , Feroz Ridah , Meghani Salima Nazim , Saleem Sarah
Published: August 2020

Background: The COVID-19 pandemic has certainly resulted in an increased level of anxiety and fear among the general population related to its management and infection spread. Due to the current unprecedented situation the normal routine life of every individual has been hindered which may cause florid mental distress. Considering the relevance of present circumstances we explored perceptions and attitudes of community members towards COVID-19 pandemic and its impact on their mental well-being. Methods: We conducted an exploratory qualitative study using a purposive sampling approach, at two communities of Karachi, Pakistan. In-depth interviews were conducted with community members including, young adults, middle-age adults, and older adults of both genders. Study data was analyzed manually using the conventional content analysis technique. Results: A total of 27 in-depth interviews were conducted, between May and June, 2020. Three overarching themes were identified: (I) Impact of COVID-19 on mental health of the general communities; (II) Current coping mechanisms to adapt to the new reality; and (III) Recommendations to address mental health of communities. Generally community members underwent increased anxiety and fear due to the contagious nature of the virus. Alongside, social, financial and religious repercussions of the pandemic have also heightened psychological distress among community members. However, community members were able to point out some of the coping mechanisms such as getting closer to God, connecting with family, participating in mental health sessions and resetting lives by indulging in diverse activities. Simultaneously, they also recommended the need of remote mental health services for elders and continuous efforts by the government to address mental health needs of the community at larger scale.Conclusion: COVID-19-associated mental health consequences have hit every individual in the society. The study finding has the potentialto guide the development of context-specific innovative mental health programs to overcome the pandemic repercussions.
Early coronary angiography and percutaneous coronary intervention for out of hospital cardiac arrest survivors without ST-segment elevation: a systematic review and meta-analysis
Authors: Huang Po , Liu Qingquan , Guo Yuhong , Li Bo , Fang Xiaolei
Published: August 2020

Objective: The meta-analysis aims to identify whether out of hospital cardiac arrest (OHCA) survivors of non ST-segment elevation (NSTE) can benefit from early coronary angiography (CAG) and percutaneous coronary intervention (PCI).Methods: The relevant studies from MEDLINE, Cochrane Library, Embase were searched by two independent investigators using a variety of keywords. Stata software (version 12.0, Stata Corp LP, College Station, TX, USA) was used for statistical analysis. Results: A total of 12 studies (9 observational studies, 1 cohort study and 2 randomized control trials) were identified and incorporated into the meta-analysis. For overall analysis, the strategy of early angiography was associated with decreased short-term (hospital discharged) mortality (RR=0.72, 95% CI=0.56-0.93, P=0.000) and long-term (follow up) mortality (RR=0.84, 95% CI=0.71-0.99, P=0.007). However, when analyzed in the subgroup of randomized controlled study, the strategy of early angiography didn’t have survival benefit in the randomized controlled study group for short-term mortality (RR=1.12, 95% CI=0.89-1.41, P=0.331) and long-term mortality (RR=1.06, 95% CI=0.85-1.32, P=0.572). Meanwhile, our analysis found that, if early CAG performed, PCI followed by CAG is not associated with hospital discharged mortality (RR=1.14, 95% CI=0.96-1.37, P=0.132) compared with CAG alone. No significant differences between the groups were found in the remaining secondary endpoints.Conclusion: Due to the observational nature of the studies available, we may consider that early CAG and PCI is not be recommended for patients with NSTE OHCA.
CDK5/CAMK2-DRP1-AMPK-Mediated Mitochondrial Fission is Required for Imatinib Resistance of CML Cells
Authors: Lu Ziyuan , Tang Jiaming , Li Yuling , Liang Guohua , Chen Xiaoyun , Luo Bing , Qu Qian
Published: August 2020

Background: In chronic myeloid leukemia (CML), resistance to tyrosine kinase inhibitors (TKIs) is still a serious clinical challenge, especially in the context of multi-resistance BCR-ABL mutations, such as T315I. Increasing evidence has demonstrated that mitochondrial fission plays an important role in cancer stem cell maintenance and drug resistance. Therefore, as a vital fission-related protein, DRP1 serves as a novel target for cancer treatment. However, whether DRP1 inhibition could overcome imatinib resistance in CML remains unknown.Methods: We used bioinformatic analysis and a confocal microscopy experimental approach to investigate whether mitochondrial fission could be involved in drug resistance in CML. Next, we applied biological and metabolic detection methods to reveal the roles of DPR1 in autophagy, apoptosis, and mitochondrial respiration in CML cells and determine whether coupling imatinib with DRP1 inhibition has a synergetic anti-leukemic effect on both drug-sensitive and drug-resistant CML cells. Results: Resistant CML cells displayed fragmented mitochondria and were accompanied by overexpression of active DRP1 compared with their sensitive counterparts. Furthermore, blocking DRP1 decreased mitochondrial respiration via the CDK5/CAMK2-DRP1-AMPK signaling pathway. Additionally, DRP1 inhibition perturbed the balance between mitochondrial-dependent apoptosis and autophagy, which led to cell death. Finally, combination treatment with imatinib and DRP1 inhibition exhibited a synergetic anti-leukemic effect on both drug-sensitive and drug-resistant CML cells (including CML cells carrying T315I mutation) in in vitro or in vivo experiments.Conclusions: Combination treatment with imatinib and DRP1 inhibition may represent a promising strategy to overcome CML drug resistance.
OrtSuite – a flexible pipeline for annotation of ecosystem processes and prediction of putative microbial interactions
Authors: Saraiva João Pedro , Gomes Marta , Kallies René , Vogt Carsten , Chatzinotas Antonis , Stadler Peter , Dias Oscar , Rocha Ulisses
Published: August 2020

Background: The exponential increase in high-throughput sequencing data and the development of computational sciences and bioinformatics pipelines has advanced our understanding of microbial community composition and distribution in complex ecosystems. Despite these advances, the identification of microbial interactions from genomic data remains a major bottleneck. To address this challenge, we present OrtSuite, a flexible workflow to predict putative microbial interactions based on genomic content. Results: OrtSuite combines ortholog clustering strategies with genome annotation based on a user-defined set of functions allowing for hypothesis-driven data analysis. OrtSuit allows users to install and run all workflow components and analyze the generated outputs using a simple pipeline consisting of 23 bash commands and one R command. Annotation is based on a two-stage process. First, only a subset of sequences from each ortholog cluster are aligned to all sequences in the Ortholog-Reaction Association database (ORAdb). Next, all sequences from clusters that meet a user-defined identity threshold are aligned to all sequence sets in ORAdb to which they had a hit. This approach results in a decrease in time needed for functional annotation. Further, OrtSuit identifies putative interspecies interactions based on their individual genomic content based on constrains given by the users. Additional control is afforded to the user at several stages of the workflow: 1) The construction of ORAdb only needs to be performed once for each specific process also allowing manual curation; 2) The identity and sequence similarity thresholds used during the annotation stage can be adjusted; and 3) Constraints related to pathway reaction composition and known species contributions to ecosystem processes can be defined. Conclusions: OrtSuit is an easy to use workflow that allows for rapid functional annotation based on a user curated database. Further, this novel workflow allows the identification of interspecies interactions through user-defined constrains. Due to its low computational demands, for small datasets (e.g. maximum 100 genomes) OrtSuit can run on a personal computer. For larger datasets (> 100 genomes), we suggest the use of computer clusters. OrtSuit is an open-source software available at https://github.com/mdsufz/OrtSuit .
Study on the COVID-19 infection status, prevention and control strategies among entry people in Shenzhen
Authors: Wang Jing-Zhong , Zou Xuan , Xu Zi-Qian , Wang Hai-Rui , Wang Bi-Xin , He Jian-Fan
Published: August 2020

Background The COVID-19 confirmed cases overseas continue to rise for months, while people overseas prefer to return at present. It is risky to have a large number of infected imported cases which may cause COVID-19 spread to China and even lead to outbreak again. In order to prevent imported infection, Shenzhen implemented the losed-loop management strategy by taking nucleic acid testing (NAT) for severe acute respiratory syndromes coronavirus 2 (SARS-CoV-2) and medical observation for 14 days among individuals who have epidemic history (Hong Kong, Macao, Taiwan province and other countries) within 14 days. Our study described the status of COVID-19 infection among entry people in Shenzhen, and also evaluated the effect of closed-loop management strategy.Methods A total of 86,844 people overseas entered Shenzhen from January 1 to April 18, 2020, and there were 39 imported cases. We made a descriptive study by analyzing the entry time, reported time, local confirmed cases in origin countries, and the number of entry people from abroad. The NAT were completed in Shenzhen center for disease control and prevention (CDC), ten district-level CDCs, as well as fever clinics.Results The infection rate of entry people was 4.49‰ (95% CI: 3.26‰ − 6.05‰). Most of the entry people or imported cases have Chinese nationality. The number of entry people and imported cases in Nanshan and Futian districts were larger than others. 15.73% of the entry people came from the US, and 12.67% came from the UK. 14 imported cases (35.9%) came from the UK, 9 (23.08%) came from the US. The imported risks from the US and UK in Shenzhen were higher than other countries or regions. According to the 14-days’ incubation period and the number of entry people, individuals from the US since Mar 9 were the high-risk population. Accordingly, entry people from the UK since Mar 13 were the high-risk population. It is important to evaluate the imported risk by analyzing local confirmed cases status in origin countries or regions and the number of entry people from these countries or regions to Shenzhen. The distribution of entry time and report time for imported cases in Shenzhen were similar. So it is important to prevent and control COVID-19 imported infection by taking NAT and medical observation at port.Conclusions It is effective to implement closed-loop management strategy for individuals who have epidemic history (Hong Kong, Macao, Taiwan province and other countries) within 14 days. In order to control COVID-19 outbreak, we need the collaboration and cooperation at the global, national, and subnational levels to prevent, detect, and respond effectively.
Determinants of Exclusive Breast Feeding Practice among HIV Positive Mothers in North East Ethiopia: A mixed method study
Authors: Girma Yonas Bizuwork , Minda Abebe , Hailu Awraris , Zegeye Betregiorgis Hailu
Published: August 2020

Background: Exclusive breast feeding (EBF) of Human Immune Virus (HIV) exposed infants for the first six months is strongly recommended and vital for protecting them against common childhood illnesses including diarrhea and pneumonia. Despite its benefit, EBF practice is low in developing countries including Ethiopia. There is a paucity of evidence for factors associated with EBF among HIV positive mothers. Objectives: To assess exclusive breast feeding practice and its associated factors among HIV positive mothers attending Prevention of mother to child transmission and Anti-retroviral therapy clinics in public Health facilities of Debre Birhan town Amhara National Regional State, Ethiopia from February 01, 2020 to Apr 30, 2020Methods: Facility based convergent mixed methods design was used to conduct the study in public Health facilities of Debre Birhan town. Structured interviewer-administered questionnaires were used to collect data from 432 participants selected by systematic random sampling technique. Epi info version 7 and SPSS version 20 were used for data entry and analysis respectively. Descriptive and inferential statistics were computed during the analysis. Two focus group discussions and 25 in-depth interviews and observational checklist were held to collect data on barriers for exclusive breast feeding practice and thematic analysis was used to identify important insights on the study topic. Bivariate and multivariate logistic regression were conducted to select candidate variable and determine adjusted effect of independent variables respectively using p-value less than 0.05. The output from multivariate logistic regression were reported with 95% confidence interval.Results: The prevalence of exclusive breast feeding, mixed feeding and exclusive formula feeding practice were 89.8%, 6.9% and 3.2% respectively. Having information about EBF (No=0.02, 95% CI; 0.01, 0.12), time taking from home to workplace (less than 30 min=4.96, 95% CI; 1.17, 20.95), disclosing HIV status (No= 0.09, 95% CI; 0.02, 0.37), place of residence (urban=5.37, 95% CI; 1.12, 25.77), living with mother/mother in-law (No=6.03, 95% CI; 1.26, 28.86), knowledge about EBF (poor knowledge=0.06, 95% CI; 0.01, 0.34) were main factors for exclusive breast feeding practice. Poor counseling, non-disclosure of HIV status and pressure from mother/mother in-law were the commonly raised reasons by FGD and IDI participants for non-exclusive breast feeding practice. Conclusions: Majority of HIV positive mothers were practicing exclusive breast feeding for the first six month. Strengthening information dissemination, providing quality health services and empowering mothers through integrated interventions help to promote exclusive breast feeding practice among mothers living with HIV.
Combinatorial therapeutic plan for COVID-19 treatment armed up with antiviral, antiparasitic, cell-entry inhibitor, and immune-boosters
Authors: Chattopadhyay Nabanita Roy , Chatterjee Koustav , Banerjee Antara , Choudhuri Tathagata
Published: August 2020

SARS-CoV-2, or novel coronavirus, is causing the fatal and contagious coronavirus disease-2019 (COVID-19) affecting thousands of people every single day. Researchers are continuously searching for any possible cure and/or vaccine, but no conclusive report is available till date. Like many others, we realize that a rapid, immediate, and elaborate strategy must be adopted to protect mankind. To avoid the time-loss due to clinical trials, we have tested some FDA-approved drugs to combat COVID-19. We accessed information from public databases and publications, and studied the mechanism of infection of SARS-CoV-2 and the interactions of various drugs with SARS-CoV-2 proteins in silico. We found a few antivirals and antiparasitic drugs to interact with important SARS-CoV-2 proteins. Particularly Galidesivir, Remdesivir, and Pirodavir are the chosen antiviral drugs; and Proguanil, Mefloquine, and Artesunate are the chosen antiparasitic drugs. In addition, inhibitors to prevent host-cell entry and a few supportive immuneboosters can be used in different combinations. Our study proposes a four-way attack to this fatal virus for the possible management of COVID-19 armed up with an antiviral, an antiparasitic drug, a cell-entry inhibitor, and a few supportive immune-boosters, which can be used in different combinations in different groups of people.
MAP3K1 Expression is Associated With Progression and Poor Prognosis of Hormone Receptor-Positive, HER2-Negative Early-Stage Breast Cancer
Authors: Kuo Sung-Hsin , Wei Ming-Feng , Lee Yi-Hsuan , Yang Wen-Chi , Yang Shi-Yi , Lin Jui-Chueh , Huang Chiun-Sheng
Published: August 2020

Background: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) participates in the MAPK signal transduction pathway, responding to a number of mitogenic and metabolic stimuli, which may be related to breast cancer susceptibility and progression. In this study, we assessed whether overexpression of MAP3K1 promotes proliferation, migration, and invasion of breast cancer cells, and thus, affects the prognosis of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early-stage breast cancer. Methods: Two HR-positive, HER2-negative breast cancer cell lines (MCF7 and T-47D), both overexpressing MAP3K1, were transfected with MAP3K1 short hairpin RNA plasmids (shMAP3K1) and their proliferation, migration, and invasion were examined. We assessed whether shMAP3K1 affects the cell cycle and levels of downstream signaling molecules, such as ERK and NF-κB, as well as sensitizes cells in both cell lines to chemotherapeutic and hormonal agents. A total of 161 patients with HR-positive, HER2-negative T1-T2 breast cancer and 0 to 3 nodal metastases were included. The expression of MAP3K1 and phospho (p)-ERK proteins was assessed by immunohistochemistry. Results: In both cell lines (MCF7 and T-47D), shMAP3K1 significantly reduced cell growth, migration, and invasion by downregulating MMP-9 and blocking the G2/M phase of the cell cycle and its regulatory molecule cyclin B1. Besides, shMAP3K1 downregulated ERK- and NF-κB-dependent gene transcription, and enhanced sensitivities of both cell lines to doxorubicin, docetaxel, and tamoxifen. Patients with MAP3K1 overexpression exhibited significantly poor 9-year disease-free survival (DFS; 72.6% vs. 88.5%, p = 0.022) and overall survival (OS; 83.8% vs. 96.2%, p = 0.012) relative to those without MAP3K1 overexpression. Furthermore, the p-ERK expression was significantly associated with MAP3K1 expression (p < 0.001) and correlated with a poor 9-year DFS (p = 0.033) and OS (p = 0.023). Conclusions: Our results indicate that overexpression of MAP3K1 plays a major role in poor prognosis of HR-positive, HER2-negative early-stage breast cancer.
Work-Related and Personal Factors Associated With Mental Well-Being During the COVID-19 Response: Survey of Health Care and Other Workers
Authors: Evanoff Bradley A , Strickland Jaime R , Dale Ann Marie , Hayibor Lisa , Page Emily , Duncan Jennifer G , Kannampallil Thomas , Gray Diana L
Published: August 2020

Background

The response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created an unprecedented disruption in work conditions. This study describes the mental health and well-being of workers both with and without clinical exposure to patients with coronavirus disease (COVID-19).

Objective

The aim of this study is to measure the prevalence of stress, anxiety, depression, work exhaustion, burnout, and decreased well-being among faculty and staff at a university and academic medical center during the SARS-CoV-2 pandemic and describe work-related and personal factors associated with their mental health and well-being.

Methods

All faculty, staff, and postdoctoral fellows of a university, including its medical school, were invited in April 2020 to complete an online questionnaire measuring stress, anxiety, depression, work exhaustion, burnout, and decreased well-being. We examined associations between these outcomes and factors including work in high-risk clinical settings and family/home stressors.

Results

There were 5550 respondents (overall response rate of 34.3%). Overall, 34% of faculty and 14% of staff (n=915) were providing clinical care, while 61% of faculty and 77% of staff were working from home. Among all workers, anxiety (prevalence ratio 1.37, 95% CI 1.09-1.73), depression (prevalence ratio 1.28, 95% CI 1.03-1.59), and high work exhaustion (prevalence ratio 1.24, 95% CI 1.13-1.36) were independently associated with community or clinical exposure to COVID-19. Poor family-supportive behaviors by supervisors were also associated with these outcomes (prevalence ratio 1.40, 95% CI 1.21-1.62; prevalence ratio 1.69, 95% CI 1.48-1.92; and prevalence ratio 1.54, 95% CI 1.44-1.64, respectively). Age <40 years and a greater number of family/home stressors were also associated with these poorer outcomes. Among the subset of clinicians, caring for patients with COVID-19 and working in high-risk clinical settings were additional risk factors.

Conclusions

Our findings suggest that the pandemic has had negative effects on the mental health and well-being of both clinical and nonclinical employees. Mitigating exposure to COVID-19 and increasing supervisor support are modifiable risk factors that may protect mental health and well-being for all workers.
Markers of Oxidative Stress in the Saliva of Type 2 Diabetic Patients (Preprint)
Authors: Olayanju Olatunde , Okwor Chika Juiet , Odok Jr Gabriel Nku , Odok Jr Gabriel Nku , Awah Nnaemeka Elvis , Edem Fabian Victory
Published: August 2020

BACKGROUND

Diabetes mellitus is associated with increased prevalence of oral diseases. Reactive oxygen species have been implicated in the development of these diseases. The saliva contains a balanced proportion of protective antioxidants and reactive oxygen species, disrupting this balance favours disease development. However, level of salivary markers of oxidative stress has not been sufficiently studied in the diabetics.

OBJECTIVE

Thus, this study aimed to measure salivary H2O2, NO and MDA in diabetic patients in comparison to non-diabetic controls.

METHODS

A total of 166 adults comprising of 95 Type 2 diabetic patients and 71 healthy non-diabetic controls were recruited for this study. About 3 ml of unstimulated saliva samples were collected from participants after rinsing their mouth with clean water. Levels of H2O2, NO and MDA were measured in all saliva samples using spectrophotometry. Data was analysed using t-test, logistic regression and receiver operating characteristics (ROC) with statistical significance set at p<0.05.

RESULTS

Salivary H2O2 (p=0.024) and NO (p=0.002) were significantly higher in the diabetic patients when compared to the healthy non-diabetic control group. Binary logistic regression showed that patients with Type 2 diabetic mellitus are more likely to have elevated salivary H2O2 (OR= 1.013; p=0.025) and NO (OR=1.016; p=0.003) levels. ROC analysis showed statistically significant performance of salivary NO levels in distinguishing between T2DM patients and healthy controls.

CONCLUSIONS

Higher levels of salivary H2O2 and NO could be a pointer to the high prevalence of oral diseases in diabetes mellitus. This calls for increased attention to oral health in diabetes management.
Descriptive Review of Online Information Resources for People With Stroke: Protocol for a Scoping Review (Preprint)
Authors: Inglis-Jassiem Gakeemah , Grimmer Karen , Conradie Thandi , Louw Quinette
Published: August 2020

BACKGROUND

People with stroke and their caregivers experience numerous information needs; internet-based resources may offer cost-effective ways to improve access to information about this condition and its management, including the availability of resources and support. The quality of online health information is, therefore, an important consideration for both developers and consumers of these online resources.

OBJECTIVE

This study aims to map and evaluate the content, readability, understandability, design, and quality characteristics of freely available online information resources (ie, websites) that empower people with stroke and their caregivers with information and self-help strategies poststroke.

METHODS

This descriptive review will follow the five systematic and rigorous methodological steps that are recommended for scoping reviews, which include the following: (1) identifying the research question, (2) identifying relevant studies, (3) selecting the studies, (4) charting the data, and (5) collating, summarizing, and reporting the results. Data will then be synthesized and analyzed thematically.

RESULTS

As of February 2021, the scoping review is in the data extraction stage. Data will be synthesized, and the first results are expected to be submitted for publication in an open-access peer-reviewed journal in August 2021. In addition, we will develop an accessible summary of the results for stakeholder meetings. Ethical approval is not required for this review, as it will only include publicly available information.

CONCLUSIONS

This study is novel and will evaluate the typology, content, and design-related criteria, including accessibility, aesthetics, navigability, interactivity, privacy, and data protection, of online information resources for stroke. The review will be limited to online resources published in English.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/23174
Thinking on the Planning and Construction of Battalion Area in Military Academies (Note)
Authors: Man Sun Jia , Yu Shang Shan , Jun Ji Hai
Published: August 2020

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Em briga de marido e mulher, o Poder Público mete a colher: mídia, mobilizações coletivas e estratégias de visibilização da violência doméstica em Portugal e no Brasil
Authors: Silva Edilson Márcio Almeida da
Published: August 2020

Dadas as transformações relativas a produção, armazenamento e fluxo de informações no mundo contemporâneo, a visibilidade dos fenômenos sociais encontra-se, não raro, relacionada ao modo como estes são tratados pela mídia. Por consequência, considerada a especificidade de sua participação na definição do que é socialmente relevante, a mídia contribui de forma decisiva para o agendamento das políticas públicas nas mais diversas áreas, inclusive na de segurança. A fim de discutir a capacidade de “agendamento” dos veículos de comunicação sobre os formuladores de políticas públicas, tomar-se-á como exemplo o processo de criminalização da violência doméstica  em Portugal, procurando assinalar a importância estratégica da mídia na sua visibilização e, por corolário, na sua construção como um dos principais problemas públicos do país. O objetivo geral do trabalho é, ainda que de forma sucinta, estabelecer uma perspectiva comparativa e contrastiva com o que, a esse respeito, se verifica no Brasil.
Políticas de philia como traduções das turbulentas sociabilidades escolares: a circulação do reconhecimento como referência na constituição dos laços políticos
Authors: Resende José Manuel
Published: August 2020

O artigo pretende desenvolver o conceito de políticas de amizade com o propósito de analisar suas consequências na construção das sociabilidades escolares, em particular, as vias sinuosas e tensionais da produção do reconhecimento de si e dos outros nas escolas secundárias portuguesas. Quais são os limites das políticas de philia, experimentadas na escola, na constituição dos laços políticos entre os atores que habitam essas arenas públicas? Que efeitos produzem as políticas de philia nos processos de reconhecimento do outro, num momento em que a exploração e a experimentação da individuação são uma marca da modernidade contemporânea? Exploramos no artigo um esboço de itinerários para questionar os dilemas dos processos de reconhecimento nos estabelecimentos de ensino.
Encontros com Licia do Prado Valladares: biografia, trajetória acadêmica e reflexões metodológicas sobre o seu trabalho de campo na Rocinha em 1967-1968
Authors: Cunha Juliana Blasi , Valladares Licia Do Prado , Mesquita Wania Amélia Belchior , Silva Luciane Soares da
Published: August 2020

Quase cinquenta anos após seu precursor trabalho de campo na Rocinha, Licia do Prado Valladares revisitou memórias, diários de campo e fotografias, abordando as relações com seus interlocutores, negociações, erros e dúvidas de seu primeiro trabalho de campo. Em uma palestra no Programa de Pós-Graduação em Sociologia Política da Universidade Estadual do Norte Fluminense em abril de 2016, a partir das memórias dessa experiência passada, Licia elaborou algumas reflexões metodológicas em que buscou destacar que as informações que se constroem dependem, no final das contas, do comportamento do pesquisador e das relações que desenvolve com o grupo pesquisado. Pouco tempo após essa palestra, realizamos uma entrevista com a autora sobre sua biografia e, posteriormente, o nosso diálogo se aprofundou no decorrer de mais quatro encontros, resultando no presente artigo. O texto aborda, portanto, aspectos da biografia da autora, o contexto de produção de sua pesquisa e, através da transcrição de parte de sua palestra, as reflexões sobre a relação estabelecida por ela com seus interlocutores.
Politização da cultura e participação social entre Brasil e Argentina: territórios e memórias em disputa
Authors: Gonçalves Renata De Sá , Infantino Julieta
Published: August 2020

Os artigos reunidos neste dossiê1 buscam problematizar, a partir de situações empíricas de pesquisa especialmente no Brasil e na Argentina, como as produções culturais de diversos grupos sociais, nesses dois países, renovam e mobilizam memórias, conhecimentos e recursos políticos, culturais, organizativos, econômicos e identitários, dando visibilidade a novas disputas dentro do espaço público. Neste campo de negociações, os setores historicamente subalternizados, jovens da “periferia” urbana (ADERALDO, 2017), grupos indígenas (CRESPO, 2013a), artistas populares (MOREL, 2011), grupos étnicos (VASSALLO; CICALO, 2015; BITTER, 2015) acionam e se organizam coletivamente por meio de associações e projetos “culturais” em resposta a políticas e projetos de modernização de cidades e territórios.
O WAYFINDING NO AMBIENTE CONSTRUÍDO HOSPITALAR
Authors: Rangel Márcia Moreira , Mont’Alvão Cláudia
Published: August 2020

O artigo apresenta o wayfinding a partir de conceitos teóricos básicos e estudos complementares, o crescente o interesse pelo wayfinding no Brasil e dados gerais da tese de doutorado com o tema cor-informação no wayfinding de hospitais. Aponta a importância das diversas variáveis do wayfinding nos projetos do ambiente construído.
Integrated skin transcriptomics and serum multiplex assays reveal novel mechanisms of wound healing in diabetic foot ulcers
Authors: Admin Ada , Theocharidis Georgios , Baltzis Dimitrios , Roustit Matthieu , Tellechea Ana , Dangwal Seema , Khetani Radhika S. , Shu Bin , Zhao Wanni , Fu Jianfang , Bhasin Swati , Kafanas Antonios , Hui Daniel , Sui Shannan Ho , Patsopoulos Nikolaos A. , Bhasin Manoj , Veves Aristidis
Published: August 2020

Non-healing diabetic foot ulceration (DFU) is characterized by low grade
chronic inflammation, both locally and systemically. We prospectively followed
a group of DFU patients who either healed or developed non-healing chronic DFU.
Serum and forearm skin analysis, both at protein expression and transcriptomic
level, indicated that increased expression of factors such as IFNγ, VEGF and sVCAM-1 were
associated with DFU healing. Furthermore, foot skin single-cell RNA-seq
analysis showed multiple fibroblast cell clusters and increased inflammation in
the dorsal skin of Diabetes Mellitus (DM) patients and DFU specimens when
compared to controls. In addition, in myeloid cells of DM and DFU patients
upstream regulator analysis, we observed inhibition of IL-13 and IFNγ and dysregulation of
biological processes that included cell movement of monocytes, migration of
dendritic cells and chemotaxis of antigen presenting cells pointing to an impaired
migratory profile of immune cells in diabetic skin. The SLCO2A1 and CYP1A1 genes,
which were up-regulated at the forearm of Non-Healers, were mainly expressed by
the vascular endothelial cell cluster almost exclusively in DFU indicating a
potential important role in wound healing. These results from integrated
protein and transcriptome analyses identified individual genes and pathways
that can potentially be targeted for enhancing DFU healing
ANALISIS PENGARUH BUDAYA ORGANISASI TERHADAP EFEKTIFITAS INTEGRATED ACADEMIC INFORMATION SYSTEM (IRAISE) UIN SUSKA RIAU
Authors: Syaifullah Syaifullah , Ozi Ozi Saputra , Hasdi Hasdi radiles
Published: August 2020

Budaya Organisasi merupakan suatu perekat sosial yang ada dalam organisasi, mengandung nilai, kebiasaan serta kepercayaan. Organisasi memiliki dampak secara langsung terhadap teknologi informasi melalui budaya organisasi. Saat ini di UIN SUSKA Riau sudah mengaplikasikan sebuah sistem informasi berbasis web yang dibangun untuk perorganisasian akademik untuk mempermudah pekerjaan. Namun walaupun sudah dibangun aplikasi berbasis web masih ada yang lalai. Oleh karena itu perlu diketahui budaya Mahasiswa yang menyebabkan kelalaian. Budaya tersebut akan digunakan sebagai pengukur efektifitas terhadap sistem informasi. Pada penelitian ini dilakukan penerapan Organiztional Culture Assesment Instrument serta Delone dan Mclean untuk budaya mahasiswa terhadap efektifitas. Dari hasil perhitungan budaya mahasiswa saat ini menggunakan tools Excel didapat hasil yaitu Clan yang menekankan kepada focus kerja sama tim, komitmen dan bersifat kekeluargaan sebesar 25.61 dan untuk diharapkan tetap budaya Clan sebesar 27.10. Hasil perhitungan di tolls SmartPLS 3 dari perhitungan budaya dan efektifitas menyatakan bahwa budaya organisasi tidak berpengaruh terhadap efektifitas sistem informasi iRaise kerena budaya Clan lebih memfokuskan pada kinerja tim, komitmen dan bersifat kekeluargaan kerena hal itu apabila salah satu anggota tim berhalangan maka pekerjaan tidak bisa diteruskan dan hal itu menyebabkan produktifitas yang kurang baik dan membuat pekeraan menjadi terlambat. Kata kunci: Budaya Organisasi, Delone dan Mclean, Efektifitas, ,Organiztional Culture Assesment Instrument, Smart PLS 3.
PENERAPAN ASSOCIATION RULE MINING UNTUK ANALISIS PENEMPATAN TATA LETAK BUKU DI PERPUSTAKAAN MENGGUNAKAN ALGORITMA APRIORI
Authors: M. Afdal M. Afdal , Rosadi Muhammad
Published: August 2020

Perpustakaan adalah sebagai gedung yang memiliki koleksi bahan pustaka (buku, majalah danmedia lainnya) yang ditata atau diatur dengan cara tertentu agar mudah dimanfaatkan oleh pengguna secara cepat dan tepat. Perpustakaan Soeman Hs memiliki 60.583 judul dan 335.745 buku. Berdasarkan hasil wawancara dalam melakukan penempatan buku diperpustakaan, buku diletakan berdasarkan kategori buku yang telah diberikan penomoran yang disebut dewey decimal classification (DDC). Namun, dalam penempatan buku belum diatur dengan melihat tingkat keseringan pengunjung dalam meminjam buku tersebut. Selain itu, pengujung kesulitan dalam mencari kembali keberadaan buku yang sering dipinjam. Untuk mengatasi masalah tersebut, maka pada tugas akhir ini penulis akan mencari buku yang sering dipinjam secara bersamaan oleh pengunjung, dengan menganalisa data transaksi peminjamaan buku menggunakan metode association rule mining. Tugas akhir ini menggunakan Algoritma Apriori. Dari data 11.550 transaksi peminjaman buku selama 3 tahun yang telah diproses menghasilkan 4 rules dengan kombinasi item terbesar adalah kategori buku agama dan ilmu sosial sering dipinjam secara bersamaan dengan nilai support 11,71% dan confidence 41,43%. Selain itu, kategori buku teknologi dan ilmu sosial sering dipinjam secara bersamaan dengan nilai support 13,8% dan confidence 40,75%. Berdasarkan hasil tersebut disaran kepada pustakawan untuk menempatkan buku-buku tersebut pada rak yang berdekatan berdasarkan kategori buku.
SISTEM INFORMASI PENJADWALAN CERAMAH MENGGUNAKAN ALGORITMA GREEDY
Authors: Mawarni Suci Ayu , Zarnelly Zarnelly , Marsal Arif
Published: August 2020

Salah satu organisasi kemasyarakatan yang berbasis kegiatan keagamaan di Indonesia adalah Majelis Dakwah Islamiyah (MDI) yang terletak di jakarta utara dan kota pekanbaru adalah lembaga dakwah yang mengemban amanat yang menjalankan dakwah Dinayah (agama), Insaniyah (kemanusiaan) dakwah Wathoniah (Patriotik). waktu yang dibutuhkan untuk membuat jadwal ceramah pada bulan ramadhan adalah lima bulan. Saat ini di MDI Pekanbaru terdapat 800 masjid/musalah dan 1088 mubaligh/mubalighah dan waktu yang dibutuhkan untuk membuat jadwal khutbah jum’at mubaligh adalah satu bulan untuk menyusun 4 bulan jadwal. Terdapat 407 masjid/musalah dan  499 mubaligh. serta harus memperhatikan empat buah kriteria, yaitu: (1) usia mubaligh; (2) kemampuan mubaligh; (3) alamat mubaligh, (4) tingkat kedisiplinan mubaligh. Penelitian ini membuat sistem informasi penjadwalan ceramah yang bisa menyusun jadwal secara otomatis menggunakan algoritma greedy untuk mengatasi permasalahan yang ada dan dapat membantu sekretaris dalam menyusun jadwal ceramah mubaligh, dengan waktu yang lebih cepat serta meminimalisir tingkat kesalahan dalam membuat jadwal (Jadwal Bentrok) antara tempat yang satu dengan tempat yang lain. Pendekatan analisis dan desain yang digunakan dalam penelitian ini adalah object oriented analysis and design (OOAD) dengan bantuan model unified modelling language (UML). Berdasarkan hasil pengujian blackbox, semua fitur-fitur di sistem ini berjalan 100%. User acceptence test menunjukkan bahwa tingkat penerimaan pengguna terhadap sistem adalah 98%.
Desarrollo y evaluación de un nuevo fertilizante nitrogenado de liberación lenta: complejo de inclusión de urea con ácido esteárico
Authors: Lucia Alejandro , Bárcena Alejandra , Costa María Lorenza , Graciano Corina
Published: August 2020

La fertilización nitrogenada a gran escala y con productos o dosis inadecuados produce contaminación del suelo y napas, como así también la eutrofización de cuerpos de agua y la contaminación del aire, llevando a la formación de lluvias ácidas. En sitios marginales para la producción agropecuaria y forestal, los ambientes son más frágiles y el riesgo de contaminación es mayor que en aquellos con mejor aptitud productiva. La utilización de fertilizantes nitrogenados de liberación lenta pueden contribuir a aportar a los cultivos la dosis de nitrógeno necesaria para no disminuir la fertilidad de los suelos, y en consecuencia, disminuir la lixiviación de formas inorgánicas de nitrógeno y la contaminación ambiental asociada.

Realizamos la síntesis y descripción de los complejos de inclusión de urea con ácido esteárico (CIU). El objetivo fue corroborar que los microorganismos del suelo o las enzimas ureasas libres, son capaces de producir la ureólisis, es decir, la liberación del amonio de la urea cuando ésta se encuentra formando parte del CIU. Evaluamos que los cristales de CIU, que presentan muy baja solubilidad en agua, pueden ser fuente de nutrientes para las plantas, es decir, que en contacto con el suelo, liberan amonio y nitrato que son las formas minerales en que las plantas pueden absorber el nitrógeno. Además, la estructura tridimensional de los cristales de CIU pueden ser utilizados para incorporar otros nutrientes o moléculas orgánicas en su estructura, como hormonas, funguicidas o insecticidas, las que serían liberadas paulatinamente, a medida que las ureasas del suelo producen la ruptura de la urea y de los cristales de CIU.
Descobrindo a língua: as relações entre fala e escrita no processo de aquisição da linguagem
Authors: Santos Willamy Matos dos
Published: August 2020

A Associação Brasileira de Linguística (Abralin), durante o período da pandemia, em 2020, promoveu uma série de mesas-redondas, transmitidas ao vivo pelo canal da associação no YouTube. O objetivo desta resenha é apresentar a mesa redonda: A criança e o uso da língua: fala, escrita e suas relações na aquisição da linguagem, que abordou o emprego da língua pela criança enquanto falante e escrevente. No primeiro momento, o professor Lourenço Chacon apresentou dados não convencionais da escrita infantil de modo a observar a relação fala/oralidade e escrita/letramento. Em seguida, a professora Marlete Diedrich explorou a aquisição da linguagem como uma experiência de significação a partir de uma perspectiva enunciativa, baseada nos postulados de Benveniste (2005). Por fim, a professora Gabriela Maria de Oliveira-Codinhoto apresentou uma proposta funcionalista de textos infantis com ênfase na frequência de utilização de orações relativas em produções textuais de crianças.
Expressões manuais e não manuais da Libras sob o olhar de pesquisadores da UFPR
Authors: Silva Lídia
Published: August 2020

A mesa redonda intitulada Aspectos fonético-fonológicos da Libras apresentada no evento Abralin ao Vivo contou com a participação de André Nogueira Xavier, Thiago Steven dos Santos e Elisane Conceição Alecrim. A mesa deu um panorama dos estudos que estão sendo desenvolvidos sobre articuladores manuais e não manuais no Programa de Pós Graduação em Letras da Universidade Federal do Paraná (UFPR). Em vista disso, os apresentadores abordaram tópicos de interesse da fonética-fonologia a partir de dados da Libras. Mostrou-se que, do ponto de vista articulatório, predominam expressões não manuais lexicais produzidas por mais de um articulador (nas partes inferiores da face) e sem mudanças em sua configuração durante a realização do sinal. Discutiu-se, também, a respeito da variação dos recursos manuais e não manuais utilizados para expressão de intensidade em Libras e sobre a variação do parâmetro configuração de mão que persiste em diferentes modelos teóricos.
O SÍNODO DA AMAZÔNIA – UM ACONTECIMENTO DEFINIDOR
Authors: Carvalho Neto Joviniano Soares de
Published: August 2020

O artigo analisa o Sínodo da Amazônia, promovido pela Igreja Católica, em Roma, de 6 a 27 de outubro de 2019. Contém apresentação do significado e relevância; análise em 3 partes: o projeto da Igreja para o Sínodo, a cobertura da mídia impressa, e a posição final do Papa; a conclusão, que inclui o Sínodo na política proposta pelo Papa Francisco de novo modelo civilizatório e conversão da própria Igreja.
Prevalência de hiperidrose primária e fatores associados em uma capital do nordeste do Brasil: estudo baseado em população
Authors: Lima Sonia Oliveira , Jesus Carla Viviane Freitas de , Ferrari Yasmim Anayr Costa , Santos Rafael Silva , Dias Edna Santos , Menezes Lorenna Oliveira , Silva Rute Nascimento da , Andrade Renata Lima Batalha de , Carvalho Felipe Mendes de Andrade de , Santana Vanessa Rocha de
Published: August 2020

Objetivo: Avaliar a prevalência de hiperidrose primária (HP) e fatores associados em uma amostrapopulacional de uma capital do nordeste brasileiro. Métodos: Estudo transversal com amostras populacionaisde cinco bairros aleatórios de uma capital do nordeste brasileiro. Questionário validado "Diagnóstico dahiperidrose primária". Resultados: De 1330 indivíduos, 34,2% homens e 65,8% mulheres. A prevalência deHP foi de 17% entre os homens, 14,9% entre mulheres e teve valor global de 15,9%. A idade média dosentrevistados foi de 25,9 ± 10,2 anos. A idade de início ocorreu principalmente entre 0 e 19 anos de idade.Tanto o suor bilateral como a piora dos sintomas com estresse apresentaram valores significativos (p<0,05).A transpiração foi principalmente bilateral, pelo menos uma vez por semana e agravada com o estresse(p<0,05). Conclusão: A prevalência de HP na população amostrada foi de 15,9%, semelhante em ambos ossexos e, na maioria dos casos, bilateral. O início dos sintomas ocorreu principalmente durante a infância eadolescência, com implicações negativas nas atividades diárias, e os sintomas primários de hiperidrose sãoexacerbados com o estresse.
Elaboração e aplicação de um modelo de visita pós-anestésica em um hospital de ensino de Belém - PA
Authors: Melo Williams Barbosa , Balieiro Anthony Benny da Rocha , Da Costa Marcio Lima , Farias Flavia Moura Gaia , Lobato Isabela Sousa , Esteves Jordana de Castro , Mesquita Fernando Monteiro , Júnior Antônio José Malcher Gillet , Barbosa Ana Luiza Souza , Pires Carla Andréa Avelar
Published: August 2020

Objetivo: Elaborar e validar um modelo de atendimento pós-anestésico em um hospital oncológico de Belém-PA. Métodos:  É estudo descritivos seccional. Os participantes da pesquisa são residentes e médicos de anestesiologia do Hospital ensino de Belém-PA. O trabalho contou com três fases, sendo a primeira uma submissão de um modelo piloto de visita pós-anestésica para avaliação por anestesiologistas, a fim de receber críticas para a confecção de um modelo sugerido de visita pós-anestésica. Na segunda, o modelo sugerido foi submetido a aplicação e avaliação pelos residentes. Já na terceira fase, o modelo sugerido de visita pós-anestésica foi submetido a avaliação pelos mesmos anestesiologistas, a fim de detectar melhora ou não. Resultados: Avaliações dos anestesiologistas foram boas para ambos os modelos, além de ter ficado evidente que o momento de aplicação de uma visita pós-anestésica deve ser ainda no expediente, deste modo evita-se que o paciente receba alta hospitalar antes da visita pós-anestésica. Conclusão: Ter um modelo de visita pós-anestésica é uma boa forma de melhorar a experiência do paciente com a anestesia e tornar os hospitais mais organizados e padronizados.
Atualizações sobre a imunização contra o sarampo no Brasil: uma revisão sistemática
Authors: Rodrigues Bruna Larissa Pinto , De Souza Larissa Ribeiro , Soares Neiva Maria dos Santos , Da Silva Karini de Nazaré Silva , Celestino Júnior Aluísio Ferreira
Published: August 2020

Objetivo: Analisar a produção científica acerca dos aspectos envolvidos no processo de imunização contra o sarampo no Brasil. Métodos: Estudo descritivo exploratório, realizado por meio de revisão sistemática da literatura, operacionalizada conforme o protocolo Preferred Reporting Itens for Systematic Reviews and Meta-Analyses (PRISMA). O levantamento de estudos bibliográficos foi realizado em bases de dados indexadas como LILACS, SciELO e MEDLINE. Resultados: O levantamento bibliográfico localizou 429 resultados. A análise das publicações resultou na amostra de 5 artigos, levantados pelos critérios estabelecidos. No período avaliado neste estudo, é possível identificar lacunas importantes na cobertura vacinal em vários locais do território nacional. As estratégias adotadas para enfrentamento do sarampo estão centradas em campanhas de vacinação, que apesar de serem comprovadamente eficazes, não têm tido a adesão necessária e há limitações que se enquadram na esteira de investimentos governamentais que poderiam impulsionar esta adesão. Considerações finais: As evidências permitiram identificar que a incompletude vacinal verificada tem como causa fatores diversos que precisam ser melhor dimensionados por novos estudos e devidamente enfrentados com estratégias consistentes que resultem em um controle mais rigoroso da enfermidade.
The rationale behind Ayurveda Codes of Conduct (Aachar Rasayana) in COVID-19 like new disorders
Authors: Sumod Khedekar  , Renu Bharat Rathi  , Bharat J. Rathi  , Amit Deshmukh
Published: August 2020

In the Pandemic of COVID-19, the Whole world is severely affected in many areas, including the health sector. Ayurveda being a holistic science also explains similar condition thousand years back with their aetiology, sign and symptoms and effective management. Such communicable diseases are described under headings such as Janapadodhwansa, Aupasargicvyadhi etc. with their effective management such as Rejuvenation (Rasayana) therapy, Panchakarma procedures, following codes of right conducts (SadvritaaPalan, AacharRasayana). Till date, there is no established protocol for the management of COVID- 19 like disorders, the only option left with us is a preventive aspect, and that is the first aim of Ayurveda. To make body and mind healthy and capable of fighting against any disease, is possible by following principles of Ayurveda. AacharaRasayana is advised for the same purpose, which is a code of conduct aimed in providing excellent mental, physical, social and spiritual health without having any medicine. Due to the change in lifestyle and not following the codes of conduct, we are becoming more prone to various diseases. Therefore, it must be implemented in the community to obtain the full span of life without disease. This article explains the Ayurvedic view ofAacharRasayana as a Preventive aspect in COVID- 19 like diseases.