bluuebunny/crossref_metadata_2025 huggingface dataset:
Aptidão cardiorrespiratória durante o teste cardiopulmonar de esforço de indivíduos com amputação unilateral de membro inferior
Authors: Costa Roberto Miranda Ramos , Castro Patrícia Marques Aroso Lisboa de , Santos Mauro Augusto dos , Mainenti Míriam Raquel Meira , Lopes Agnaldo José , Vigário Patrícia dos Santos
Published: November 2021

Introdução: A amputação de membros inferiores impacta na mobilidade dos indivíduos, podendo levar a uma baixa aptidão cardiorrespiratória. O consumo máximo de oxigênio (VO2máx) é tradicionalmente utilizado para descrever a aptidão cardiorrespiratória. Contudo, a sua obtenção nem sempre é viável em populações com limitações funcionais e, por isso, análises em níveis submáximos de esforço podem ser uma estratégia eficiente. Objetivo: Testar a hipótese de que indivíduos com amputação unilateral de membro inferior possuem aptidão cardiorrespiratória menor em diferentes intensidades de esforço comparados a indivíduos sem amputação. Métodos: Estudo seccional com 6 indivíduos com amputação de membro inferior e 10 indivíduos sem amputação. A aptidão cardiorrespiratória foi investigada pelo teste de esforço cardiopulmonar, sendo considerados: VO2pico absoluto e relativo, limiar ventilatório 1 (LV1) e Ponto Ótimo Cardiorrespiratório (POC). Resultados: Os indivíduos amputados apresentaram menor VO2pico absoluto e relativo que os não amputados. O valor absoluto do POC, o tempo e a carga, não se diferiram entre os grupos, porém o grupo com amputação apresentou o POC em um maior percentual do VO2pico (p = 0,007) e em um menor VO2 relativo e absoluto (p = 0,004 e p = 0,009, respectivamente). No LV1, não houve diferença entre os grupos no tempo, carga e percentual do VO2pico, contudo os amputados apresentaram menor VO2 relativo e absoluto (p = 0,046 e p = 0,032, respectivamente). Conclusão: Indivíduos com amputação de membro inferior apresentaram menor aptidão cardiorrespiratória em diferentes intensidades de esforço quando comparados com indivíduos sem amputação, porém apresentaram a maior eficiência entre os sistemas respiratório e circulatório em um maior %VO2pico.
Paradigmas no ensino da ciência contemporânea: grilhões inconscientes?
Authors: Sacramento Marvyn de Santana do , Souza Carlos Eduardo , Moreira Jackeline Barbosa , Vitavar Lorena Mariel González
Published: November 2021

Avanços na tecnologia modificaram diversos aspectos da comunicação, e isso inclui o meio científico. O formato de apresentação do conteúdo, divulgação, disponibilidade e velocidade de compartilhamento são exemplos da discrepância entre o antigo modelo de disseminação das informações científicas e o atual. No entanto, a forma de ensinar a pesquisa científica no ensino superior (que permeia desde a iniciação científica até o doutorado) ainda cultiva ideias retrógradas que dificultam o real aprendizado sobre as necessidades para fazer e transmitir ciência com qualidade. O objetivo desse artigo é questionar alguns dos equívocos no ensino da pesquisa e da escrita científica. Afinal, as repercussões de tais aspectos podem se apresentar como barreiras para o aprendizado e/ou afasta os autores da publicação dos seus estudos. Portanto, se o desenvolvimento da ciência e a construção de uma sociedade cientificamente alfabetizada é realmente um propósito, precisamos rever a forma como ensinamos pesquisa.
O exercício físico pode contribuir no tratamento do câncer de mama?
Authors: Santana Robson Santos , Silva Wasly Santana , Petto Jefferson
Published: November 2021

O câncer é uma das principais causas de morte no mundo, com mais de 9 milhões de óbitos em 2018 [1,2]. No Brasil, estima-se que entre 2020 e 2022 ocorrerão 625 mil novos casos de câncer, e desses, 65 mil serão pelo câncer de mama [2].
O câncer de mama é o que mais mata mulheres no Brasil [2]. Apesar de sua incidência ser maior em países desenvolvidos, a mortalidade relativa é superior nos países em desenvolvimento [3]. Entre as causas estão: acesso ao serviço de saúde qualificado, políticas de saúde para mulheres com câncer e educação em saúde para a população...
Obtención de curvas de motores de inducción usando un circuito equivalente de parámetros variables
Authors: Gallo Omar Dionisio , Ferreyra Diego Martìn
Published: November 2021

Este estudio trata sobre la graficación de las curvas características, en función de la velocidad, de motores asincrónicos trifásicos de potencias inferiores a 450 kW.
Se usa el circuito equivalente convencional, los datos de ensayos o del fabricante y se procesa la información con lenguaje Python de programación; se calculan impedancias variables, se aplican hipótesis simplificativas, recomendaciones de normas y estimaciones de pérdidas.
Se presentan las devoluciones del programa y algunas de las curvas obtenidas, entre los momentos de arranque y el funcionamiento en vacío. Se agregan las devoluciones bajo distintos estados de carga normalizados y los valores de exigencias eléctricas y magnéticas.
Se pretende aportar un método alternativo para el estudio de motores trifásicos de inducción, con toda la desviación que esto puede incluir, aplicando los principios tradicionales de análisis teórico, los resultados prácticos de los ensayos y un lenguaje moderno de programación.
Pengaruh Aplikasi PPA Kader terhadap Pengetahuan Kader tentang Deteksi Dini Stunting
Authors: Febrina Fika Kristi , Antarsih Novita Rina
Published: November 2021

Stunting is a growth disorder due to a lack of nutritional intake for a long time. Data from the World Health Organization (WHO), the prevalence of stunting in Indonesia is the third highest in Southeast Asia. The PPA Kader application is one solution in helping to overcome the stunting problem because cadres can get information on nutritional status assessments so fast and can detect stunting early. PPA Kader application for monitoring the growth is an android-based application based on the Z-Score value (BB/U, TB/U, BMI/U, and BB/TB), an imaginative and provocative medium for health education. To find out the effect of the PPA Kader application on the knowledge of village health workers about early stunting detection. This research was using pre-experimental research in one group pre-test post-test design. The research sample is 35 respondents taken from the village health worker population at the Integrated Services Post (Posyandu) in the area of the Public Health Center (Puskesmas) in Balik Bukit District with purposive sampling technique. This research was conducted from March to April. The intervention in this study was carried out using the PPA Kader application in which there was an educational explanation video about stunting. The data in this study were obtained through questionnaires that have been prepared for the pre-test and post-test to find out the knowledge of village health workers about early detection of stunting. Statistical test knowledge in this study is using Wilcoxon test. PPA Kader application can increase knowledge (p=0.000) of village health workers about early detection of stunting. The PPA Kader application affects the knowledge level of village health workers in the target area of the Balik Bukit District Health Center.
Perkembangan Motorik dan Psikososial dengan Stunting pada Anak Prasekolah
Authors: Pangaribuan Helena , Mangemba Dg. , Musaidah Musaidah , Appulembang Imelda
Published: November 2021

Stunting is a global problem faced by the world and often occurs in children aged 3 – 5 years. The negative impact that will be caused by stunting in the 3-5 year age period in the long term is the disruption of children's psychosocial and motoric development. This study aims to see the relationship between motor and psychosocial development with stunting in preschool children (3 – 5 years) at the Baluse Health Center, Sigi Regency. The research design used was a cross-sectional study that assessed the relationship between motor and psychosocial development and stunting in preschool children (aged 3 – 5 years). The population used in this study were all preschool children (aged 3 – 5 years) with stunting in the Puskemas Baluse. The number of samples was 25 respondents who met the criteria for the research sample. The research was carried out at the Baluse Health Center, Sigi Regency from October 5 to 20, 2020. The research instrument used a questionnaire to measure the motoric and psychosocial development of children, while the measurement of stunting used microtoise and children's scales. The closeness and strength of the relationship between the two variables in this study used the Chi-Square statistical test. The results showed that most of the motor and psychosocial developments were in the abnormal category. The test of the relationship between motor and psychosocial development and stunting was carried out using the Chi-Square statistical test. The results showed that the P-value = 0.016 is smaller than the alpha value of 0.05, this indicates that stunting has a significant relationship with the motoric and psychosocial development of children. This study concludes that stunting has a relationship with motor and psychosocial development of children aged 3 – 5 years. Stunting children mostly have an abnormal motor and psychosocial development.
Analisis Ketahanan Pangan dan Karakteristik Rumah Tangga dengan Kejadian Stunting
Authors: Sihite Nathasa Weisdania , Nazarena Yunita , Ariska Firda , Terati Terati
Published: November 2021

Stunting is a condition of chronic growth failure experienced by toddlers that can cause children to experience difficulties in achieving optimal growth and development according to their age. Stunting can be minimized if the factors that affect stunting in the region can be controlled properly. Many factors are thought to influence the incidence of stunting, one of which is food security. If food insecurity occurs in a household, this can increase the proportion of stunting events that are increasing which can directly increase the national stunting incidence rate and will continue to be a major health problem in Indonesia. Indonesia. The purpose of this study was to analyze the relationship between household food security and household social factors with the incidence of stunting. The research was conducted in Palembang City, precisely at the 11 Ilir Health Center in Palembang. The research method used is a cross-sectional design. The determination of the research sample was carried out by purposive sampling based on the inclusion and exclusion criteria of the sample that had been determined in this study. The research sample was toddlers aged 0 – 59 months totaling 40 people. Analysis of the data used is chi-square with = 0.05. In this study, it was found that there was a significant relationship between household food security (p = 0.031), and household size (p = 0.000) with the incidence of stunting, while for the variable mother's age (p = 0.393) and mother's education level (p = 0.283) is known to have no significant relationship with the incidence of stunting. Household food security is directly related to the incidence of stunting, families in households who are not food insecure tend to have children under five who are classified as stunting, this is due to the lack of nutritional intake received both in terms of quantity and quality and does not meet the nutritional adequacy standard for stunting toddlers. It is hoped that to reduce the incidence of stunting, the government needs to add a local food-based work program in reducing the incidence of stunting.
Dual Role Conflict and Social Support on the Performance of Women Entrepreneurs with Disabilities During the Covid-19 Pandemic (An Initial Research)
Authors: Handayani Penny , Evienia Benedicta , Wijayanti Sri Hapsari , Widyani Regina , Frenicha Frenicha
Published: November 2021

During the COVID-19 pandemic, many female entrepreneurs are trying to maintain their household financial cycles from the businesses they own. Therefore, they need social support from their family and environment to maintain the business performance that they had built before the COVID-19 pandemic. This research is the initial research of a large umbrella of research with the topic of Analysis of the Effect of Multiple Role Conflicts on Performance Women Entrepreneurs During the COVID-19 Pandemic with Social Support as Moderating Variable. This study examines the picture of dual role conflict and social support on the performance of women entrepreneurs with disabilities during the Covid-19 pandemic. The outputs are expected to help women entrepreneurs with disabilities maintain their business performance by reducing dual role conflicts and getting social support from the surrounding environment. Data collection was carried out with a qualitative approach with snowball sampling which was taken through interviews with six selected respondents. The characteristics of the sample are: 1) Female: married and (was) married, has at least 1 child, 2) Have a business/entrepreneurship for at least the last 6 months, 3) People with hearing disabilities, and 4) Domiciled on the island of Java. Based on the results of the study, the effect of multiple roles on the performance of women entrepreneurs was slightly felt in families with children aged over 12 years, while housewives who had children under 12 years had a considerable influence. The performance of women entrepreneurs during the Covid-19 pandemic has increased, this is due to declining economic conditions. While forms of social support that help women entrepreneurs to maintain their performance as entrepreneurs during the Covid-19 pandemic are instrumental support, informational support, emotional support, and positive assessments obtained from family and friends. Social support is the main thing for women entrepreneurs to overcome dual role conflicts in their families, the social support they get comes from the family so that dual role conflicts in the family do not occur in women entrepreneurs.
Exploring Ethnic and Gender Equity Enrollment and Achievement Patterns in High School CTE Career Pathways in Mississippi
Authors: Finch Dustin D. , Owen, Ph.D.* Sean , Thames Cliff , Alexander Ben
Published: November 2021

This study, a post hoc observational one, attempted to understand how to continue promoting equitable opportunities in career and technical education (CTE) for the state of Mississippi. We explored the enrollment patterns of Mississippi secondary CTE students by career cluster and career pathways associated with STEM careers over the last five years. Additionally, the enrollment patterns were compared to statewide enrollment patterns by gender and ethnicity. Also, we examined the proficiency results of students on the statewide CTE assessment by gender and ethnicity. Our secondary CTE student enrollment results are like previous reports of underrepresentation of nontraditional students in STEM-related career fields. Additionally, similar results were found when looking at the statewide CTE assessment data. However, there is an indication that CTE and non-CTE leaders effectively recruit underrepresented populations to STEM-related career pathways in the state of Mississippi, but more work is needed to allow access to all students.
Zola and the Science of Painting
Authors: Lethbridge Robert
Published: November 2021

The article explores a paradox in Zola's writing: the resistance to advances in scientific theory by the author of Du Progrès dans les sciences et dans la poésie (1864), as the first of many such assimilations of scientific progress and artistic trends. This is exemplified by the challenge posed to his Naturalist aesthetic by Michel-Eugène Chevreul's seminal De la loi du contraste simultané des couleurs (1839), popularised during the period of Zola's most sustained art criticism. This radical revision of the science of optics is increasingly accommodated in contemporary painting, from 1880 onwards, at the very moment of Zola's disenchantment with Impressionism. Although L'Œuvre, his novel of 1886, is set in the Second Empire (consistent with the historical limits of Les Rougon-Macquart), Zola inserts into his narrative the theory of complementary colours, the awkward anachronism notwithstanding, to explain his fictional painter's creative impotence. In relation to the latter, the article looks in detail at the genesis and textual details of a key passage in the novel in which Zola's irony at the expense of Chevreul's theories is almost explicit. At least as telling is his response to unsolicited advice about them: ‘J’ai plus de confiance dans l'observation directe que dans la théorie’. One could hardly conjure up a more succinct summary of Zola's unreconstructed approach to the science of painting which simultaneously testifies to his own principles of representation.
De L'œil du savant au regard impudique dans La Curée
Authors: Campmas Aude
Published: November 2021

La Curée is a novel about financial excesses and sexual appetites. A problem arises for Zola: how to describe sexual acts and avoid censorship? Zola's strategy is to portray sexuality in a slightly indirect way. He uses a scientific gaze as an alibi to describe human sexuality. This article demonstrates how Zola combines references to botany and fairground anatomy for this purpose. Botany allows Zola to write about sexuality in a way that is both explicit and indirect. In addition, the naturalistic method of observation offers a ‘neutral’ scientific perspective of sexuality. Finally, references to anatomical Venuses allow the pseudo-pedagogical observation of the naked female body. Therefore, an indecent, voyeuristic gaze reveals itself behind science as alibi, behind the naturalist gaze.
Émile Zola and the Literary Language of Climate Change
Authors: Ungelenk Johannes
Published: November 2021

On 7 February 1861, John Tyndall, professor of natural philosophy, delivered a historical lecture: he could prove that different gases absorb heat to a very different degree, which implies that the temperate conditions provided for by the Earth's atmosphere are dependent on its particular composition of gases. The theoretical foundation of climate science was laid.

Ten years later, on the other side of the Channel, a young and ambitious author was working on a comprehensive literary analysis of the French era under the Second Empire. Émile Zola had probably not heard or read of Tyndall's discovery. However, the article makes the case for reading Zola's Rougon-Macquart as an extensive story of climate change. Zola's literary attempts to capture the defining characteristic of the Second Empire led him to the insight that its various milieus were all part of the same ‘climate’: that of an all-encompassing warming. Zola suggests that this climate is man-made: the economic success of the Second Empire is based on heating, in a literal and metaphorical sense, as well as on stoking the steam-engines and creating the hypertrophic atmosphere of the hothouse that enhances life and maximises turnover and profit. In contrast to Tyndall and his audience, Zola sensed the catastrophic consequences of this warming: the Second Empire was inevitably moving towards a final débâcle, i.e. it was doomed to perish in local and ‘global’ climate catastrophes.

The article foregrounds the supplementary status of Tyndall's physical and Zola's literary knowledge. As Zola's striking intuition demonstrates, literature appears to have a privileged approach to the phenomenon of man-induced climate change.
‘Awakening the echoes of the ancient faith’: the National Pilgrimages to Iona
Authors: Grenier Katherine Haldane
Published: November 2021

This article examines two pilgrimages to Iona held by the Scottish Roman Catholic Church in 1888 and 1897, the first pilgrimages held in Scotland since the Reformation. It argues that these religious journeys disrupted the calendar of historic commemorations of Victorian Scotland, many of which emphasized the centrality of Presbyterianism to Scottish nationality. By holding pilgrimages to “the mother-church of religion in Scotland” and celebrating mass in the ruins of the Cathedral there, Scottish Catholics challenged the prevailing narrative of Scottish religious history, and asserted their right to control the theological understanding of the island and its role in a “national” religious history. At the same time, Catholics’ veneration of St. Columba, a figure widely admired by Protestant Scots, served as a means of highlighting their own Scottishness. Nonetheless, some Protestant Scots responded to the overt Catholicity of the pilgrimages by questioning the genuineness of “pilgrimages” which so closely resembled tourist excursions, and by scheduling their own, explicitly Protestant, journeys to Iona.
‘Magnus's vision of a resurgent Scotland was elusive as a unicorn’: Scottish Nationalism in Eric Linklater's Magnus Merriman
Authors: Gilbert Adam
Published: November 2021

Eric Linklater's 1934 novel Magnus Merriman is recognised as a comic triumph for its satirical treatment of the Scottish Renaissance and the associated contemporary Scottish nationalist movement. This article argues that Magnus Merriman has deceptive depth because Linklater offers frequently profound insights into a compelling point in Scottish cultural and political history. The misadventures of the eponymous Magnus have strong parallels with Linklater's own belated entry into the Scottish Literary Renaissance and his disastrous attempt at standing for parliament as a Scottish nationalist candidate. The novel showcases Linklater's idiosyncratic political doctrine of ‘small nationalism’, and his unflattering portrayal of the National Party of Scotland is coloured by his disillusionment with it. The doomed poem written by Magnus, ‘ The Returning Sun’, symbolises the Scottish Renaissance, reflecting its shortcomings and the difficulty of forming a unified Scottish cultural identity. The character of Magnus himself embodies the lack of a single, coherent Scottish identity as a Scottish Renaissance anti-hero. Magnus's political and literary disappointments mean Linklater gives a pessimistic assessment of the relative failure of the Scottish Renaissance and the nationalist movement of the period. Linklater's irreverent examination of Scottish nationalism retains contemporary relevance. Magnus Merriman is more than just a hilarious comedy and represents a significant contribution to Scottish literature.
The Relationship Between Queen Bee Syndrome, Glass Ceiling and Resilience: Female Teachers | Kraliçe Arı Sendromu, Cam Tavan ve Yılmazlık Arasındaki İlişki: Kadın Öğretmenler
Authors: APAYDIN Çiğdem , GÖKGÜL Merve , ALAN AYDINER Ayşegül , EMİR Oktay
Published: November 2021

This research aims to reveal the relationship between queen bee syndrome, glass ceiling and resilience. Accordingly, answer to the question regarding the female teachers’ views on the factors that affect queen bee syndrome, glass ceiling and resilience. The research tested the theoretical model which shows the relationship between queen bee syndrome, glass ceiling and resilience and the factors were modeled. The model was modified by removing the dimensions of family life, self confidence and stereotyped biases related to the glass ceiling. Having a relational survey model, the research used stratified sampling method to determine the target population. The research sample held a total of 377 female teachers working in public schools in Antalya province. This research deployed “Queen Bee Syndrome”, “Glass Ceiling” and “Resilience” scales developed by the researchers. SPSS 13.00 and LISREL 8.70 statistical package programs were used during data analysis. The research findings suggested that female teachers were free from any no solidarity behavior. A significant relationship was identified across queen bee syndrome, glass ceiling and resilience. There was also found a high relationship between queen bee syndrome and glass ceiling but a low and positive correlation between queen bee syndrome and resilience. A negative and low relationship was noted between resilience and glass ceiling.
ANALISIS BUTIR SOAL EVALUASI TEMA 1 KELAS 4 SDN PLUMBUNGAN MENGGUNAKAN PROGRAM ANATES
Authors: Mochammad Noor Akhmadi
Published: November 2021

Program anates digunakan untuk mengetahui ciri-ciri butir soal evaluasi tema 1 kelas 4. Pada penilitian ini pengumpulan data menggunakan Teknik dokumen dengan pendekatan dekriptif kuantitatif. Alat tes berupa soal evaluasi tema 1 kelas 4 berjumlah 20 soal berupa dokumen tes pilihan ganda. Soal evaluasi tema 1 kelas 4 direspon oleh 20 siswa dengan menggunakan aplikasi program anates versi 4.0.9 dengan jumlah 20 dokumen . Setelah dilakukan analisis, hasil yang didapat menunjukkan indeks daya pembeda dikategorikan tinggi karena jumlah butir soal yang bisa digunakan untuk membedakan kelompok atas dan bawah adalah 50%. Tingkat kesukaran butir soal kategori sedang dengan nilai prosentase sebesar 64%. Validitas tes sebesar 80% kategori sangat tinggi. Reliabilitas butir soal sangat tinggi dengan nilai indeks sebesar 0.80. Efektifitas distraktor pada soal evaluasi Penilaian Tengah Semester Tema 1 Kelas IV hanya 40 % yang berfungsi dengan baik.

Kata Kunci: Karakteristik Butir, Soal Evaluasi PTS, Program Anates
AN ANALYSIS OF FEMINISM IN MERRY RIANA : MIMPI SEJUTA DOLAR MOVIE
Authors: Fitri Apriyanti  , Rahmi Aulia Nurdini
Published: November 2021

In literary works, films cannot be separated from life, one of which discusses the issue of discrimination against women, a phenomenon that continues to be actively debated in society and gave birth to the feminism movement. Feminism can also appear through films, one of which is Merry Riana. Therefore, this paper aims to find out what is meant by feminism and how feminism is reflected in films and associated with liberal feminism. This study uses a qualitative method with sources from the original Merry Riana video. The writer uses data collection techniques from online sources. The data were collected by watching the film and understanding the film's dialogue several times and making observations to strengthen the analysis using the semiotic theory by Charles Sanders Pierce. The results of this study indicate that: (1) 8 data indicate the presence of elements of feminism in Merry Riana's action. (2) Feminism is shown through Signs, Objects and Interpreters. (3) In liberal feminism, it proves that women are not only focused on the private sphere, but can also be in the public sphere.

Key words: Literature, Movie, Merry Riana, Feminism
PENGEMBANGAN MEDIA FLASHCARD PADA MATERI TATA SURYA KELAS VII DI MTSN 11 JOMBANG
Authors: Nur Izzatun Nikmah  , Andri Wahyu Wijayadi
Published: November 2021

Penelitian ini bertujuan untuk mendeskripsikan proses pengembangan media flashcard pada materi tata surya kelas VII di MTsN 11 Jombang berdasarkan prosedur pengembangan ADDIE dan mendeskripsikan produk hasil pengembangan setelah proses validasi. Penelitian pengembangan ini menggunakan model pengembangan ADDIE, yaitu Analisis, Rancangan, Pengembangan, Implementasi, dan  Evaluasi. Penelitian pengembangan yang dilakukan tanpa adanya tahap implementasi dikarenakan pandemi Covid-19. Data hasil penelitian yang diperoleh dianalisis secara deskriptif kuantitatif. Hasil pengembangan media flashcard pada materi tata surya kelas VII di MTsN 11 Jombang setelah proses validasi diperoleh kriteria sangat valid dengan persentase 95,4%. Berdasarkan hasil uji validitas media flashcard ini valid digunakan dalam proses pembelajaran.

Kata kunci: Media Flashcard, Model ADDIE, Tata Surya
The Development of Lectora Inspire Media Based on Jombang Local Culture for
Authors: Debiya Lenon , Asmarani Ratih
Published: November 2021

Process in SD level requires learning media to attract students' enthusiasm for learning. activities in classroom can follow the development without reducing moral education and student creativity. Introduction of local culture is necessary in the learning process so that students can understand the culture around them. This study to determine the development of media by Lectora inspire with cultural in country for the fourth grade of SD, and to find the quality of media in learning SD. This research was carried out at SD Kepanjen 2 Jombang in May 2020/2021 using R&D (Research and Development) but refers to design of ADDIE and its acronym is Analyze, Design, Development, Implementation, and Evaluation. The subjects of the media trial were 20 from class IV-A SD Kepanjen 2 Jombang. The research instrument used a validation sheet and questionnaire with quantitative data analysis techniques and qualitative data. The results of the study in validity percentage is 94.775%. (very valid also worthy of use without improvement), with each material expert rating of 91.55% (very valid also eligible to be used without improvement), and media experts of 98% (very valid also eligible to be used without improvement). The product trial from students obtained an overall percentage assessment of 90.45% (very interesting), while the educator's assessment of 91.7% Lectora inspire-assisted learning media was very interesting and very suitable for use in elementary learning. So it can be concluded that the interactive media developed is very valid and can also be used in learning.
Exclusion and Inequality in Late Working Life: National Country Context: UK
Authors: Alden Sarah , Foster Liam , Walker Alan
Published: November 2021

Extending Working Lives (EWLs hereafter) is an important policy goal across many Western countries. This document traces how policy developments have formed the existing EWLs agenda in the UK context. It explores the interrelationship between demographic shifts, policy reform, changing organisational and cultural practices, and technological drivers across groups with diverse life course trajectories. It needs to be borne in mind that UK development is influenced by wider, global influences and shared experiences, such as the OECD level shift toward later retirement pathways. There are also imminent political and cultural changes taking place in the UK which will have an ongoing influence on EWLs, such as the European Union exit. Section 7 provides an overview of the development and framing of policies relevant to EWL, as well as levels of participation. Section 8 focuses on macro national regime characteristics and socio-demographic characteristics across subgroups of older people. Section 9 goes into greater detail on the main inequalities which have a negative impact on EWLs and Section 12 draws on the key policies that impact on EWLs, with consideration of the main inequalities within this.
POLEMIK PENYIARAN PUBLIK DI INDONESIA: POTRET KONDISI TVRI
Authors: COMMED Jurnal
Published: November 2021

Public service broadcasting (PBS) has a central role in the terminology of the democratic broadcasting system. The role of PBS institutions is aspired to be an information balancing institution by bringing democratic values, plurality, and maintenance the cultural values of society. In Some Countries, Public broadcasting are not always in ideal conditions. Some Problems in internal and pressure from external are the factors that often hinder it. This article try to seeks the picture of condition of PBS in Indonesia, especially TVRI. The discussion is doing by tracing the history of birth and development, the problems present, and the challenges of the future that facing TVRI. This article uses a qualitative descriptive approach by using literature review method. The collecting of data doing by use literature review technique on relevant sources.
Automated Individual Cattle Identification Using Video Data: A Unified Deep Learning Architecture Approach
Authors: Qiao Yongliang , Clark Cameron , Lomax Sabrina , Kong He , Su Daobilige , Sukkarieh Salah
Published: November 2021

Individual cattle identification is a prerequisite and foundation for precision livestock farming. Existing methods for cattle identification require radio frequency or visual ear tags, all of which are prone to loss or damage. Here, we propose and implement a new unified deep learning approach to cattle identification using video analysis. The proposed deep learning framework is composed of a Convolutional Neural Network (CNN) and Bidirectional Long Short-Term Memory (BiLSTM) with a self-attention mechanism. More specifically, the Inception-V3 CNN was used to extract features from a cattle video dataset taken in a feedlot with rear-view. Extracted features were then fed to a BiLSTM layer to capture spatio-temporal information. Then, self-attention was employed to provide a different focus on the features captured by BiLSTM for the final step of cattle identification. We used a total of 363 rear-view videos from 50 cattle at three different times with an interval of 1 month between data collection periods. The proposed method achieved 93.3% identification accuracy using a 30-frame video length, which outperformed current state-of-the-art methods (Inception-V3, MLP, SimpleRNN, LSTM, and BiLSTM). Furthermore, two different attention schemes, namely, additive and multiplicative attention mechanisms were compared. Our results show that the additive attention mechanism achieved 93.3% accuracy and 91.0% recall, greater than multiplicative attention mechanism with 90.7% accuracy and 87.0% recall. Video length also impacted accuracy, with video sequence length up to 30-frames enhancing identification performance. Overall, our approach can capture key spatio-temporal features to improve cattle identification accuracy, enabling automated cattle identification for precision livestock farming.
A Performance-Based Wind Engineering Framework for Engineered Building Systems Subject to Hurricanes
Authors: Ouyang Zhicheng , Spence Seymour M.J.
Published: November 2021

Over the past decade, significant research efforts have been dedicated to the development of performance-based wind engineering (PBWE). Notwithstanding these efforts, frameworks that integrate the damage assessment of the structural and envelope system are still lacking. In response to this need, the authors have recently proposed a PBWE framework that holistically treats envelope and structural damages through progressive multi-demand fragility models that capture the inherent coupling in the demands and damages. Similar to other PBWE methodologies, this framework is based on describing the hurricane hazard through a nominal straight and stationary wind event with constant rainfall and one-hour duration. This study aims to develop a PBWE framework based on a full description of the hurricane hazard in which the entire evolution of the storm track and time-dependent wind/rain fields is simulated. Hurricane-induced pressures impacting the building envelope are captured through the introduction of a non-stationary/-straight/-Gaussian wind pressure model. Time-dependent wind-driven rain is modeled through a computational fluid dynamics Eulerian multiphase framework with interpolation schemes for the rapid computation of wind-driven rain intensities over the building surface. Through the development of a conditional stochastic simulation algorithm, the envelope performance is efficiently characterized through probabilistic metrics associated with rare events of design interest. The framework is demonstrated through analyzing a 45-story archetype building located in Miami, FL, for which the envelope performance is estimated in terms of a suite of probabilistic damage and loss metrics. A comparative study is carried out in order to provide insights into the differences that can occur due to the use of nominal hurricane models.
Earthquake Damage Reduction in Timber Frame Houses Using Small-Size Fluid Damper
Authors: Nakamura Yutaka , Fujii Hinako
Published: November 2021

Timber frame structures are common traditional methods of housing construction, which use squared-off timber beams, columns, and walls as lateral load-bearing members. The seismic performance of timber frame houses can be secured by the load-bearing capacity of erected braces and walls; however, past major earthquakes have caused severe damage to earthquake-resistant timber frame houses. This study investigates the effect of small-size fluid dampers on the earthquake damage reduction in a timber frame house through earthquake response analyses. A detailed analytical model was generated based on an actual two-story timber frame house, which was designed for the highest seismic grade using the latest Japanese standards. Time-history response analyses were carried out for the analytical model subjected to the 2016 Kumamoto earthquake with and without small-size fluid dampers. The small-size fluid damper is equipped with a relief mechanism for the damping force, and its damping property can be expressed using the Maxwell model. Four or seven fluid dampers were installed in the first story of the model to investigate their effect on the earthquake damage reduction. The results of the earthquake response analyses show that the four and seven fluid dampers can reduce the maximum first-story drift angle by approximately one-third and half, respectively. The dampers suppress the residual deformation, control the elongation of the fundamental period during the response, and restrain the amplitude growth. A small-size fluid damper has an equivalent quake resistance to a conventional structural wall with a wall ratio of 3 plus.
The Dynamics of Aerotaxis in a Simple Eukaryotic Model
Authors: Biondo Marta , Panuzzo Cristina , Ali Shahzad M. , Bozzaro Salvatore , Osella Matteo , Bracco Enrico , Pergolizzi Barbara
Published: November 2021

In aerobic organisms, oxygen is essential for efficient energy production, and it acts as the last acceptor of the mitochondrial electron transport chain and as regulator of gene expression. However, excessive oxygen can lead to production of deleterious reactive oxygen species. Therefore, the directed migration of single cells or cell clumps from hypoxic areas toward a region of optimal oxygen concentration, named aerotaxis, can be considered an adaptive mechanism that plays a major role in biological and pathological processes. One relevant example is the development of O2 gradients when tumors grow beyond their vascular supply, leading frequently to metastasis. In higher eukaryotic organisms, aerotaxis has only recently begun to be explored, but genetically amenable model organisms suitable to dissect this process remain an unmet need. In this regard, we sought to assess whether Dictyostelium cells, which are an established model for chemotaxis and other motility processes, could sense oxygen gradients and move directionally in their response. By assessing different physical parameters, our findings indicate that both growing and starving Dictyostelium cells under hypoxic conditions migrate directionally toward regions of higher O2 concentration. This migration is characterized by a specific pattern of cell arrangement. A thickened circular front of high cell density (corona) forms in the cell cluster and persistently moves following the oxygen gradient. Cells in the colony center, where hypoxia is more severe, are less motile and display a rounded shape. Aggregation-competent cells forming streams by chemotaxis, when confined under hypoxic conditions, undergo stream or aggregate fragmentation, giving rise to multiple small loose aggregates that coordinately move toward regions of higher O2 concentration. By testing a panel of mutants defective in chemotactic signaling, and a catalase-deficient strain, we found that the latter and the pkbR1null exhibited altered migration patterns. Our results suggest that in Dictyostelium, like in mammalian cells, an intracellular accumulation of hydrogen peroxide favors the migration toward optimal oxygen concentration. Furthermore, differently from chemotaxis, this oxygen-driven migration is a G protein-independent process.
Long Non-Coding RNA Lacuna Regulates Neuronal Differentiation of Neural Stem Cells During Brain Development
Authors: Ninou Elpinickie , Michail Artemis , Politis Panagiotis K.
Published: November 2021

Although long non-coding RNAs (lncRNAs) is one of the most abundant classes of RNAs encoded within the mammalian genome and are highly expressed in the adult brain, they remain poorly characterized and their roles in the brain development are not well understood. Here we identify the lncRNA Lacuna (also catalogued as NONMMUT071331.2 in NONCODE database) as a negative regulator of neuronal differentiation in the neural stem/progenitor cells (NSCs) during mouse brain development. In particular, we show that Lacuna is transcribed from a genomic locus near to the Tbr2/Eomes gene, a key player in the transition of intermediate progenitor cells towards the induction of neuronal differentiation. Lacuna RNA expression peaks at the developmental time window between E14.5 and E16.5, consistent with a role in neural differentiation. Overexpression experiments in ex vivo cultured NSCs from murine cortex suggest that Lacuna is sufficient to inhibit neuronal differentiation, induce the number of Nestin+ and Olig2+ cells, without affecting proliferation or apoptosis of NSCs. CRISPR/dCas9-KRAB mediated knockdown of Lacuna gene expression leads to the opposite phenotype by inducing neuronal differentiation and suppressing Nestin+ and Olig2+ cells, again without any effect on proliferation or apoptosis of NSCs. Interestingly, despite the negative action of Lacuna on neurogenesis, its knockdown inhibits Eomes transcription, implying a simultaneous, but opposite, role in facilitating the Eomes gene expression. Collectively, our observations indicate a critical function of Lacuna in the gene regulation networks that fine tune the neuronal differentiation in the mammalian NSCs.
The Dysferlin Transcript Containing the Alternative Exon 40a is Essential for Myocyte Functions
Authors: Ballouhey Océane , Courrier Sébastien , Kergourlay Virginie , Gorokhova Svetlana , Cerino Mathieu , Krahn Martin , Lévy Nicolas , Bartoli Marc
Published: November 2021

Dysferlinopathies are a group of muscular dystrophies caused by recessive mutations in the DYSF gene encoding the dysferlin protein. Dysferlin is a transmembrane protein involved in several muscle functions like T-tubule maintenance and membrane repair. In 2009, a study showed the existence of fourteen dysferlin transcripts generated from alternative splicing. We were interested in dysferlin transcripts containing the exon 40a, and among them the transcript 11 which contains all the canonical exons and exon 40a. This alternative exon encodes a protein region that is cleaved by calpains during the muscle membrane repair mechanism. Firstly, we tested the impact of mutations in exon 40a on its cleavability by calpains. We showed that the peptide encoded by the exon 40a domain is resistant to mutations and that calpains cleaved dysferlin in the first part of DYSF exon 40a. To further explore the implication of this transcript in cell functions, we performed membrane repair, osmotic shock, and transferrin assay. Our results indicated that dysferlin transcript 11 is a key factor in the membrane repair process. Moreover, dysferlin transcript 11 participates in other cell functions such as membrane protection and vesicle trafficking. These results support the need to restore the dysferlin transcript containing the alternative exon 40a in patients affected with dysferlinopathy.
Crosstalk Between Inflammatory Signaling and Methylation in Cancer
Authors: Das Dipanwita , Karthik Nandini , Taneja Reshma
Published: November 2021

Inflammation is an intricate immune response against infection and tissue damage. While the initial immune response is important for preventing tumorigenesis, chronic inflammation is implicated in cancer pathogenesis. It has been linked to various stages of tumor development including transformation, proliferation, angiogenesis, and metastasis. Immune cells, through the production of inflammatory mediators such as cytokines, chemokines, transforming growth factors, and adhesion molecules contribute to the survival, growth, and progression of the tumor in its microenvironment. The aberrant expression and secretion of pro-inflammatory and growth factors by the tumor cells result in the recruitment of immune cells, thus creating a mutual crosstalk. The reciprocal signaling between the tumor cells and the immune cells creates and maintains a successful tumor niche. Many inflammatory factors are regulated by epigenetic mechanisms including DNA methylation and histone modifications. In particular, DNA and histone methylation are crucial forms of transcriptional regulation and aberrant methylation has been associated with deregulated gene expression in oncogenesis. Such deregulations have been reported in both solid tumors and hematological malignancies. With technological advancements to study genome-wide epigenetic landscapes, it is now possible to identify molecular mechanisms underlying altered inflammatory profiles in cancer. In this review, we discuss the role of DNA and histone methylation in regulation of inflammatory pathways in human cancers and review the merits and challenges of targeting inflammatory mediators as well as epigenetic regulators in cancer.
Origin of the Functional Distinctiveness of NF-κB/p52
Authors: Ghosh Gourisankar , Wang Vivien Ya-Fan
Published: November 2021

The transcription regulators of the NF-κB family have emerged as a critical factor affecting the function of various adult tissues. The NF-κB family transcription factors are homo- and heterodimers made up of five monomers (p50, p52, RelA, cRel and RelB). The family is distinguished by sequence homology in their DNA binding and dimerization domains, which enables them to bind similar DNA response elements and participate in similar biological programs through transcriptional activation and repression of hundreds of genes. Even though the family members are closely related in terms of sequence and function, they all display distinct activities. In this review, we discuss the sequence characteristics, protein and DNA interactions, and pathogenic involvement of one member of family, NF-κB/p52, relative to that of other members. We pinpoint the small sequence variations within the conserved region that are mostly responsible for its distinct functional properties.
Neuromuscular Development and Disease: Learning From in vitro and in vivo Models
Authors: Fralish Zachary , Lotz Ethan M. , Chavez Taylor , Khodabukus Alastair , Bursac Nenad
Published: November 2021

The neuromuscular junction (NMJ) is a specialized cholinergic synaptic interface between a motor neuron and a skeletal muscle fiber that translates presynaptic electrical impulses into motor function. NMJ formation and maintenance require tightly regulated signaling and cellular communication among motor neurons, myogenic cells, and Schwann cells. Neuromuscular diseases (NMDs) can result in loss of NMJ function and motor input leading to paralysis or even death. Although small animal models have been instrumental in advancing our understanding of the NMJ structure and function, the complexities of studying this multi-tissue system in vivo and poor clinical outcomes of candidate therapies developed in small animal models has driven the need for in vitro models of functional human NMJ to complement animal studies. In this review, we discuss prevailing models of NMDs and highlight the current progress and ongoing challenges in developing human iPSC-derived (hiPSC) 3D cell culture models of functional NMJs. We first review in vivo development of motor neurons, skeletal muscle, Schwann cells, and the NMJ alongside current methods for directing the differentiation of relevant cell types from hiPSCs. We further compare the efficacy of modeling NMDs in animals and human cell culture systems in the context of five NMDs: amyotrophic lateral sclerosis, myasthenia gravis, Duchenne muscular dystrophy, myotonic dystrophy, and Pompe disease. Finally, we discuss further work necessary for hiPSC-derived NMJ models to function as effective personalized NMD platforms.