bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of extended-spectrum beta-lactamase-producing E. coli and Klebsiella spp in effluents of different hospitals sewage in Biratnagar, Nepal
Authors: Mahato Sanjay , Mahato Ajay , Pokharel Elina , Tamrakar Ankita
Published: August 2019

ObjectiveThis study was aimed to determine prevalence and resistance pattern like multidrug resistant (MDR) or ESBL nature of E. coli and Klebsiella spp from various sewage drain samples with an idea to deliver baseline information that could be utilized for defining guidelines for the treatment of hospital sewages.ResultsOf 10 sewage samples analyzed, 7 (70%) contained E. coli while 6 (60%) contained Klebsiella. Except one sample, all positive samples contained both E. coli and Klebsiella spp. E. coli isolates were resistant to ampicillin, amoxicillin, cefoxitin, cefuroxime, and cefpodoxime; while 85.7% were resistant to amoxicillin/clavulanate, ceftazidime, cefotaxime and ceftriaxone. 71.4%, 57.1%, 42.9%, and 28.6% were resistant to aztreonam, trimethoprim/sulfamethoxazole, nitrofurantoin, and gentamicin. Most were sensitive to chloramphenicol, ofloxacin, ciprofloxacin, and azithromycin. 85.7% and 57.1% of E. coli were MDR and ESBL isolates respectively. Klebsiella were resistant to ampicillin, amoxicillin, and amoxicillin/clavulanate. 83.4% of Klebsiella were resistant to cefoxitin. 66.7% of strains were resistant to cefuroxime, ceftazidime, cefotaxime, ceftriaxone, and cefpodoxime. Klebsiella showed 50% resistant to aztreonam and trimethoprim/sulfamethoxazole, while 33.3% were resistant to chloramphenicol, nitrofurantoin, ofloxacin, and ciprofloxacin. Klebsiella were sensitive to azithromycin and gentamicin. 66.7% and 33.3% of Klebsiella were MDR and ESBL isolates respectively.
Risk Factors Associated with Silicosis among Zambian Copper Mine Workers: A Retrospective Case Record Review
Authors: Zimba Japhet , Dambe Rosalia , Siulapwa Yolam , Musonda Patrick
Published: August 2019

Background: Silicosis is the most important occupational disease worldwide and is regarded as a major public health challenge in developing countries. The disease is mainly related to exposure to crystalline silica dust, and once the disease has been established, no treatment exists. There is less focus on other factors that are related to one acquiring the disease among the people at greater risk of developing silicosis. The main aim of this study was to assess the risk factors associated with developing silicosis among Konkola Copper Mine workers in Zambia.
Methods: A retrospective case review study was used, consisting of 168 Konkola Copper Mine Workers. A data extraction checklist was used to collect data on miners from the occupational hygiene silicosis registers. Data was analyzed using STATA version 12.0; a quantile-quantile plot was used to test for normality of continuous variables such as age and a chi-squared test was used to ascertain association with development of silicosis. Adjustment for the effect of other factors was computed using an investigator led stepwise multiple logistic regression method.
Results: For each year increase in length of service, Konkola Copper Miners are 1.95 times more likely to develop silicosis adjusting for other factors such as business unit, job category (95% CI 1.92-1.99, p=0.033). Miners working in the production areas were highly susceptible to developing silicosis compared to those working in other areas. Within the production area, miners working underground represented 38% of silicosics, while those working at open pit only had 10%. Miners belonging to Konkola and Nchanga business unit were 5.42 and 5.96 times more likely to develop silicosis compared to those working in other units respectively.
Conclusions: As a result of the statistical analysis, our findings suggest that the factors considered best predictors of silicosis were length of service, business unit and the job category to which the miners belonged to (P-values 0.033, 0.001, <0.001 respectively). There is need to reduce the length of service that individuals work underground, strengthen control measures regarding utilization of personal protective equipment, health education programs, frequent job rotations (for unskilled labour) and adherence to periodical medical examinations.
Pregnancy outcome of patients with septic shock complicating pregnancy: a retrospective study
Authors: Li Manyu , Yin Jie
Published: August 2019

Background: To detect the maternal and neonatal outcomes of late pregnant patients complicated with sepsis shock. Methods: The medical records of all late pregnant patients (>=28 weeks) complicated with septic shock during January 2011 and November 2018 in Peking Union Medical College Hospital were retrospectively reviewed. Pertinent literature was identified by searching PubMed and EMBASE. Results: A total 9 patients with an average age of 26.11±6.9 years were included in this study. And the mean gestational age at diagnosis of septic shock was 33 weeks plus 1 day. 87.5% of patients accepted emergency delivery ,in which cesarean section was the main delivery mode. 7 patients underwent emergency delivery (including 3 cases of fetal death) and 3 cases of live births (including 1 case of mild neonatal asphyxia). The total maternal mortality rate was 33.3 percent,and neonatal death rate was 55.6%. Only 1 patient continued pregnancy after disease recovery. 15 published case reports were reviewed. The reported maternal and perinatal death rates were 20% and 46.7% respectively. 2 patients could continue pregnancy after treatment. Group A streptococcus was considered as the main pathogenic bacteria. Conclusions: Late pregnancy complicated with septic shock was associated with high maternal and fetal mortality. Emergency delivery was advised in most of patients. And cesarean section was the main mode of delivery.
Mediating Effects of Metacognitive Learning Strategies in the Relationship between Learning-related Emotions and Academic Self-efficacy with Academic Performance in Medical Students
Authors: Hayat Ali Asghar , Shatery Karim , Amini Mitra , Shokrpour Nasrin
Published: August 2019

Recognition of the factors affecting the medical students’ academic success is one of the most important challenges and concerns in medical schools. Hence, this study aimed to investigate the mediating effect of metacognitive learning strategies in the relationship between learning-related emotions and academic self-efficacy with academic performance in medical students. Methods: The present study was carried out on 279 students of medicine studying in Shiraz University of Medical Sciences. The students filled out three questionnaires: academic emotions (AEQ), metacognitive learning strategies, and academic self-efficacy questionnaires. The data were analyzed using SPSS and Smart PLS3. Results: The results of structural equation modeling revealed that the students’ self-efficacy has an impact on their positive emotions and metacognitive learning strategies, and these in turn affect the students’ academic performance. Moreover, positive emotions influence the metacognitive learning strategies which in turn mediate the effect of positive emotions on the academic performance. Discussion: The results of this study revealed that metacognitive strategies can play a mediating role in the students’ self-efficacy, positive emotions, and academic performance. Therefore, in case we can strengthen the students’ self-efficacy and their positive academic emotions, their performance will improve.
Robotic, laparoscopic or open hemihepatectomy for giant liver hemangiomas of over 10 cm in diameter
Authors: Hu Minggen , Chen Kuang , Zhang Xuan , Li Chenggang , Song Dongda , Liu Rong
Published: August 2019

Background To evaluate the clinical efficacy of robotic, laparoscopic, and open hemihepatectomy for giant liver hemangiomas. Methods From April 2011 to April 2017, consecutive patients who underwent hemihepatectomy for giant liver hemangiomas were included into this study. According to the type of operation, these patients were divided into the robotic hemihepatectomy (RH) group, the laparoscopic hemihepatectomy (LH) group, and the open hemihepatectomy (OH) group. The perioperative and short-term postoperative outcomes were compared among the three groups. The study was reported following the STROCSS criteria. Results There were no significant differences in age, sex, tumor location, body surface area (BSA), future liver remnant volume (FLR), standard liver volume (SLV), liver hemangioma volume, FLR/SLV, resected normal liver volume / resected volume, hepatic disease, rates of blood transfusion, liver function after 24 hours of surgery, operative morbidity and mortality among the three groups. Compared with patients in the RH group (n=19), and the LH group (n=13), patients in the OH group (n=25) had significantly longer postoperative hospital stay (P< 0.05), time to oral intake (P < 0.05), time to get-out-of-bed (P < 0.05), a higher VAS score after 24 hours of surgery (P < 0.05) and a shorter operative time (P < 0.05). There were no significant differences in these postoperative outcomes (P>0.05) between the RH group and the LH group. When the setup time in the RH group was excluded, the operative time of the RH group was significantly shorter than the LH group (P<0.05). There was no significant difference in the operative time between the RH group and the OH group (P>0.05). The intraoperative blood loss of the RH group was the least among the three groups (P<0.05) and the intraoperative blood loss of the LH group was less than the OH group (P<0.05). Discussion Robotic, laparoscopic, and open hemihepatectomy were safe and efficacious treatments for giant liver hemangiomas. Robotic and laparoscopic hemihepatectomy were significantly better than open hemihepatectomy in intraoperative blood loss, postoperative recovery and pain score. Compared with laparoscopic hemihepatectomy, robotic hemihepatectomy resulted in significantly less intraoperative blood loss and shorter operative time.
Cause and Predictors of Neonatal Mortality among Neonates admitted to Neonatal Intensive Care Units of Public Hospitals in eastern Ethiopia: Facilities based Prospective follow-up study
Authors: Desalew Assefa , Sintayehu Yitagesu , Teferi Nardos , Amare Firehiwot , Geda Bifitu , Worku Teshager , Abera Kebebush , Asefaw Abiyot
Published: August 2019

Background: The first month is the most crucial period for child survival. Neonatal mortality is stagnated in sub-Saharan Africa including Ethiopia. And the trend in reduction is slower than infant and child mortality. The facilities-based cause and predictor of neonatal death in the neonatal intensive care unit were not well documented in this study setting. Hence the aim of this study was to determine the cause and predictors of neonatal mortality among neonates admitted in neonatal intensive care units in eastern Ethiopia.
Method: Facilities-based prospective follow-up study was conducted among neonates admitted in neonatal intensive care units of public hospitals in eastern Ethiopia from November to December 2018. Data were collected using pre-tested, structured questionnaire and follow-up checklist. The main outcomes, cause of death was set by senior pediatricians and residents. Epi-Data 3.1 and SPSS 25 version software were used for entry and analysis. Binary logistic regression was used to find out the predictors of facilities-based neonatal mortality.
Result: The proportion of facilities-based neonatal mortality was 20%. The top five cause of death was a complication of prematurity 49%, birth asphyxia 37.8%, infection 32.6%, meconium aspiration syndrome 17.3% and congenital malformation 6.1%. Low birth weight, preterm births, length of stay, low 5 th minutes Apgar score, hyperthermia and initiation of feeding were predictors of neonatal death among Neonates admitted in neonatal intensive care units in public hospitals, eastern Ethiopia.
Conclusion
In summary, the proportion of facilities-based Neonatal death was unacceptably high. The main causes of death were preventable and treatable. Hence, early detection, anticipating high-risk newborns and timely intervention is very essential. Furthermore, early initiation of feeding and a better referral linkage to tertiary facilities could contribute for reduction of neonatal death in this setting.
Keywords: Facilities based study, Neonatal mortality, predictors, NICU, Ethiopia
Reliability of Standardized Reporting System of acute appendicitis in adults at low-dose 320-rows CT
Authors: Mahankali Shravan , Razek Ahmed Abdel , abubacker shefeek , chavan venugopal naik
Published: August 2019

Aim: To assess reliability of standardized reporting system of acute appendicitis at low-dose 320-rows CT.

Methods: Retrospective analysis CT of 78 patients with pathologically proven acute appendicitis. The study was performed at low-dose 320-rows CT. The image analysis was performed by 2 radiologists according to standardized reporting system of acute appendicitis.

Results: There was excellent overall of inter-observer agreement of both observers for standardized reporting system of acute appendicitis ( K = 0.89, 95% CI = 0.87-0.92, P = 0.001). There was good inter-observer agreement for visualization of appendix (K = 0.78, P = 0.001), tip diameter ( K = 0.75, P = 0.001), and single wall thickness of appendix ( K =0.77, P = 0.001). There was excellent inter-observer agreement for outer to outer wall diameter ( K = 0.82 , P = 0.001), mucosal hyper-enhancement ( K =0.80, P = 0.001), appendicolith ( K = 0.86, P = 0.001), gas in appendix ( K = 0.82, P = 0.001), surrounding fat stranding ( K = 0.81, P = 0.001), focal cecal thickening ( K = 0.85, P = 0.001), peri-appendiceal air ( K = 0.87, P = 0.001), peri-appendicular fluid collection, phlegmon, or abscess ( K = 0.82, P = 0.001), and right ovary cyst ( K = 0.83, P = 0.001).

Conclusion: we concluded that excellent reliability of standardized reporting system of acute appendicitis in adults using low-dose 320-rows CT.
Adolescent pregnancy and parenting: Perceptions of healthcare providers
Authors: Govender Desiree , Naidoo Saloshni , Taylor Myra
Published: August 2019

Background

Adolescent pregnancy and parenting have attracted much attention as global public health and social concerns. Several studies have reported the prevalence of adverse maternal and child health outcomes due to adolescent pregnancy and it has been highlighted that the care rendered by healthcare providers plays a pivotal role in the health and well-being of pregnant and parenting adolescents. However, a dearth of available literature suggests that the role of healthcare providers as a source of sexual-related and reproductive health information is limited, regarding adolescent women in general.

Aim

The aim of this study was to explore healthcare providers’ perceptions of adolescent pregnancy and parenting.

Methods

A descriptive qualitative study was conducted at a district hospital in the Ugu district in KwaZulu-Natal, South Africa. Healthcare providers rendering care to pregnant and parenting adolescents were recruited from the maternity, antenatal, paediatrics, psychology, dietetics, physiotherapy and social work departments, as well as from the HIV/AIDS, STIs and TB (HAST) programme. The sample comprised 33 healthcare providers who were individually interviewed. The data were analysed using thematic analysis.

Results

The healthcare providers acknowledged that adolescent pregnancy is a problematic issue in Ugu district. Furthermore, they felt that the postpartum sexual-related and reproductive health of adolescent mothers was not given priority. In the healthcare providers’ view, the problems experienced by pregnant and parenting adolescents were school dropout, financial constraints, breakdown of relationships, abandonment, stigmatisation, parenting and child rearing difficulties, and both physical and mental health problems. Some of the participants were of the opinion that healthcare services were not channelled towards pregnant and parenting adolescents

Conclusion

The findings will contribute to existing literature on adolescent pregnancy as perceptions of adolescent pregnancy and parenting were elicited from a diverse group of healthcare providers. When appropriately disseminated, the findings will assist relevant healthcare providers, administrators in healthcare institutions, policy makers, and officials of the Department of Health and the Department of Education in South Africa to address the lack of appropriate care for pregnant and parenting adolescents. Our findings also highlight the need for a multidisciplinary approach to the care of pregnant and parenting adolescents.
Cost of incorrect application of antithrombotic prophylaxis prior to invasive procedures
Authors: Cuevas María Victoria , Martínez-Sancho Ignacio , Arribas Jana , García-Díaz Covadonga , Cuevas Beatriz
Published: August 2019

Background

We analyze the cost of an incorrect application, by the hematologist, of bridging anticoagulation in patients with low-risk atrial fibrillation (AF) needing interruption of treatment prior to a scheduled invasive procedure. Although not recommended, bridging therapy is widely used, resulting in avoidable costs and increased workload.

Methods

Observational retrospective study. We recorded demographic and clinical data including age, sex, type of procedure, use of bridging therapy with low molecular weight heparin (LMWH), and hemorrhagic complications within 30 days of acenocoumarol withdrawal.

Results

Acenocoumarol was stopped in 161 patients, 97 (60%) were male and 64 (40%) female. Average age was 76,11 ± 8,45 years. Procedures included: minor surgical intervention 58 (36%), colonoscopy 61 (38%), gastroscopy 11 (7%), breast biopsy 4 (2.5%), prostate biopsy 4 (2.5%), infiltration 5 (3%), and other 18 (11%). All patients received bridging anticoagulation with LMWH (40mg enoxaparin per day) 3 days before and 3 days after the procedure (6 doses). We used a total of 966 doses, at €4.5 per unit, resulted in €4,347 of total cost. No complications occurred in 156 patients (97%). Hemorrhage was observed in 5 cases: 1 major hemorrhage needing 6 days of hospital stay and transfusion, and 4 minor hemorrhages (2 patients needed Emergency attendance and 2 required hospital admission for 3 and 2 days, respectively). The cost of Emergency care was €237.36, and the cost of hospital stay was €6860.81 (€623.71 per day, for 11 days). The total cost of the incorrect application of the protocol was €11445.17.

Conclusion

Guidelines about bridging anticoagulation in low risk AF patients undergoing scheduled invasive procedures were not followed. This practice increments the complications and supposes an increase in costs besides to an inadequate use of the human resources.
Prognostic value of IGFBP7 in solid tumors: a meta analysis of 1,305 patients
Authors: Chen Borong , Huang Heqing , Xu Jiuhua , Li Lulu , Ye Weipeng , Zhu Zhipeng , Zeng Junjie , Li Jiayi , Huang Zhengjie
Published: August 2019

Background : Insulin-like growth factor-binding protein 7 (IGFBP7) has been detected to act as a cancer suppressor gene in different types of human carcinoma. Previous studies have presented controversial evidences between the expression of IGFBP7 and prognosis in solid tumors. A comprehensive meta-analysis was performed to investigate the prognostic role of IGFBP7 expression. Methods: The studies were identified through extensive electronic search of Web of Science, PubMed and Embase up to Jun 2019. The pooled hazard ratios (HR) with corresponding 95% confidence intervals (CI) for overall survival (OS) were calculated through univariate analysis and multivariate analysis to investigate the prognostic value of IGFBP7 expression . Heterogeneity, publication bias and subgroup analyses were also performed. Results: Seven eligible studies including 1,305 patients were extracted in this analysis. The pooled hazard ratio of univariable analysis for OS (HR = 0.60; 95% CI, 0.54–0.66, P < 0.001). The pooled hazard ratio of multivariate analysis for OS (HR = 0.57; 95% CI, 0.50–0.64, P < 0.001). In addition, subgroup analysis showed that low IGFBP7 expression was significantly associated with poor prognosis in patients with digestive system cancer. Conclusions: Low-expression of IGFBP7 was correlated strongly with worse OS, which indicated that IGFBP7 might be a new biomarker for prognosis prediction and a promising therapeutic target in solid tumors. Keywords: IGFBP7, prognosis, meta-analysis
The frequency and impact of admission hyperglycemia on short term outcome of acute stroke patients admitted to Tikur Anbessa teaching hospital, Addis Ababa, Ethiopia
Authors: Zewde Yared Zenebe , Mengesha Abenet Tafesse , Gebreyes Yeweyenhareg Feleke , Naess Halvor
Published: August 2019

Background:- Although acute stroke accompanied by hyperglycemia is often associated with worse prognosis, the relationship between hyperglycemia and stroke outcome has not been studied in Ethiopian patients. As better understanding of this potentially adverse influence on stroke outcome would provide guidance for stroke management and acute care. This study aimed to determine frequency of admission hyperglycemia and its impact on thirty day functional outcome and case fatality among acute stroke patients in an urban setting in Ethiopia.
Methods:- From July to December 2016, we collected information on 103 consecutive first ever acute stroke patients admitted within 72 hours of symptom onset to Tertiary hospital in Ethiopia. We obtained demographic, clinical and neuro-imaging data including capillary blood glucose at admission. National Institute of Health Stroke Scale and modified Rankin Scale were used to assess the baseline stroke severity and the degree of disability at thirty day.
Results:- A total of 103 first ever acute stroke patients were enrolled with, mean age = 55.5+ 15.3 years, 64.1% male, 65% under the age of 65 years, and 31.1% were farmers by occupation . Fifty one (49.5%) patients had a documented hyperglycemia at admission with median National Institute of Health Stroke Scale score of 14 and 3(2.9%) of them were later diagnosed with diabetes mellitus. The mean modified Rankin score at 30-day was 3.6 + 1.45 while 34 (79.1%) of hyperglycemic stroke survivors scored between 3 and 5. Older age >65 years (p = 0.037), admission hyperglycemia (p = 0.04) and stroke severity (p <0.001) were significantly correlated with poor functional outcome.
Conclusions:- High blood glucose on admission was significantly associated with sever disability in acute stroke patients, independent of the presence of diabetes mellitus. By establishing the negative impact of admission hyperglycemia on the neurological outcome, this study suggests that achieving normal blood glucose in the early stages of stroke could have a favorable impact on improved neurological outcome and quality of life for stroke patients. The study provides a rationale for acute stroke management that addresses the potentially adverse consequences of hyperglycemia at the time of presentation in an urban Ethiopian setting.
Exploración y análisis de las competencias informacionales de los futuros maestros y maestras de educación primaria (Exploration and analysis of the informational competences of future teachers of primary education)
Authors: Quintero Ordoñez Belén , Reche Urbano Eloísa , González López Ignacio
Published: August 2019

El objetivo del estudio es explorar el nivel de conocimientos y habilidades que presentan los futuros maestros y maestras de la etapa de Educación Primaria sobre aspectos claves de las competencias informacionales, en concreto, para la búsqueda, evaluación y procesamiento de la información y la comunicación del conocimiento, así como el grado de importancia que para ellos tiene la adquisición de estas destrezas. Por medio de un diseño de carácter descriptivo no experimental basado en técnicas de encuesta, se contó con la participación del 70.58% del alumnado del Centro de Magisterio Sagrado Corazón de la Universidad de Córdoba (España), al cual se le implementó un protocolo de valoración escalar al comienzo del segundo semestre del curso 2018-2019. Evidenciada la normalidad de los datos obtenidos, los resultados revelan que los diferentes elementos que definen las competencias informacionales son percibidos por este alumnado como importantes, destacando los que configuran el procesamiento de la información. Por otro lado, cuando se le solicita su nivel de destreza en los mismos, la valoración disminuye significativamente en todos los casos, resaltando lo relativo a la comunicación del conocimiento. Todo ello ha dado lugar a la identificación de una serie de necesidades de formación que son claves para la gestión de las citadas competencias en su programa curricular
Estudio de caso sobre el desarrollo de habilidades metacognitivas en estudiantes con necesidades educativas especiales por medio de ambientes de aprendizaje basados en la Web para la enseñanza de la Ciencias Sociales (A Case Study on The Development of Metacognitive Skills In Students With Special Educational Needs Through Web-Based Learning Environments For Teaching Social Sciences)
Authors: Mendoza Lucero , Huertas Adriana , Ugarte José
Published: August 2019

La presente investigación tuvo como objetivo implementar una estrategia para la enseñanza de las Ciencias Sociales fundamentada en la metacognición en un Ambiente de Aprendizaje Basado en la Web - AABW que promueva el desarrollo de habilidades metacognitivas y el avance del logro académico en estudiantes con Necesidades Educativas Especiales -NEE. Para el desarrollo de la investigación se realizó un estudio de caso con 4 estudiantes (3 hombres y 1 una mujer) de grado noveno con NEE de un colegio público de la ciudad de Bogotá, Colombia. El estudio se implementó a partir de cuatro fases; en la primera, se proyectó el problema de investigación, se sustentó teóricamente y se establecieron los aspectos metodológicos.
The problems of development of the tourism industry in Georgia
Authors: Devadze Anzor , Prokopenko Olha , Zhuravka Fedir
Published: August 2019

Recently, there has been a sharp increase in the number of foreign tourists and revenues from international tourism in Georgia. At the same time, it was noted that the country’s tourism potential is not being used effectively enough, and the main reason for this is the insufficient development of the infrastructure of the tourism industry. The main problems that hamper the development of international tourism in the country are identified. In order to enhance the competitiveness of the tourism industry in Georgia and to achieve its significant improvement, the relevant strategic objectives have been developed.
Local authorities and tourism: the role of regional tourist products in Poland
Authors: Sanetra Bożena , Sanetra-Półgrabi Sabina
Published: August 2019

The article indicates the role of local authorities in influencing the development of tourism, including the creation of regional tourism products. The aim of paper is to define and characterize the capabilities of local authorities concerning the development of tourism, including legal, organizational, investment and promotional instruments. Also, the importance of regional tourism products was substantiated, including their structure, conditions and approaches to creation as well, as their role in regional development. The article is an introduction to in-depth research on the importance of regional tourism products in providing social and cultural security.
Qualidade de vida dos cirurgiões-dentistas do Distrito Federal, Brasil
Authors: Pereira Letícia Diniz Santos Vieira , Santos Maria Teresa Botti Rodrigues
Published: August 2019

Qualidade de Vida; Organização Mundial da Saúde; Questionários
O Programa de Educação pelo Trabalho para a Saúde como porta de entrada para o protagonismo da docência na saúde
Authors: Castardeli Edson , Castardeli Carmen , Pinto Tiago Rocha
Published: August 2019

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Alterações craniofaciais, posturais e temporomandibulares associadas à respiração bucal em escolares de 7 a 13 anos
Authors: Finck Nathalia Silveira , Santos Neto Edson Theodoro dos , Araújo Maria Teresa Martins de , Pacheco Maria Christina Thomé
Published: August 2019

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Hipertensão arterial em escolares de 7 a 10 anos: um estudo de casos persistentes de alteração de pressão arterial em Santa Maria de Jetibá/ES
Authors: Nascimento Larissa Rangel , Monteiro Lorenna Narducci , Pereira Taisa Sabrina Silva , Mill José Geraldo , Molina Maria del Carmen Bisi
Published: August 2019

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Perfil epidemiológico dos casos novos de câncer infanto-juvenil em hospital de referência no Espírito Santo, Brasil, de 1986 a 2010
Authors: Zouain-Figueiredo Gláucia Perini , Zandonade Eliana , Amorim Maria Helena Costa , Figueiredo Lucas Zouain , Binda Letícia Apelfeler
Published: August 2019

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Tuberculose e a questão social: uma revisão sistemática de estudos brasileiros
Authors: Sales Carolina Maia Martins , Nunes Gabriela Ferreira , Rogério Wesley , Castro Tiago , Santos Bárbara Reis , Maciel Ethel Leonor Nóia
Published: August 2019

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Prevalência de hipotensão ortostática na população geral de adultos e de idosos
Authors: Velten Ana Paula Costa , Mill José Geraldo
Published: August 2019

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Educação versus gestão: impasses da Educação Permanente em Saúde
Authors: Mattedi Juliane Pereira Pimenta , Quintanilha Bruna Ceruti , Wandekoken Kallen Dettmann , Dalbello-Araujo Maristela
Published: August 2019

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Avaliação da satisfação e percepção de mudanças entre usuários de um programa de alcoolismo
Authors: Vieira Camila Barcelos , Cardoso Lorena Silveira , Siqueira Marluce Mechelli de
Published: August 2019

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Traumatismo dentário: prevalência em adolescentes de 15 a 19 anos no município de Santa Teresa/ES, Brasil
Authors: Campos Denise Maria Kroeff de Souza , De Almeida Eliete Rodrigues , Miotto Maria Helena Monteiro de Barros , Barcellos Ludmila Awad , Campos Fernanda de Souza
Published: August 2019

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Uso de suplementos de ácido fólico e ferro em gestantes de uma unidade de saúde do Paraná
Authors: Murakami Patricia Yumiko , Höfelmann Doroteia Aparecida
Published: August 2019

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Perfil epidemiológico da doença inflamatória pélvica nas mulheres atendidas nos centros de estratégia saúde da família na cidade de Montes Claros/MG
Authors: Gontijo Lucília Silva , Fonseca Alice de Oliveira Dias , Bispo Kamilla Silva
Published: August 2019

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Qualidade da água em serviços de alimentação de um bairro da zona rural de São Luís, Maranhão, Brasil
Authors: Mouchrek Adenilde Nascimento , Carvalho Eulália Cristina Costa de
Published: August 2019

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Curta SUS: avaliação sobre um projeto de cinema e educação popular na promoção à Saúde Pública
Authors: Coutinho Chenya Valença , Dias Gustavo Ávila
Published: August 2019

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Componentes para diagnóstico de Síndrome Metabólica pelo NCEP-ATP III em uma população afro-brasileira
Authors: Maurer Patrícia , Gullich Angelica Aparecida da Costa , Retamoso Vanessa Rosa , Freitas Eva Ribeiro Villanova de , Bruno Jamila Benvegnu , Berro Lyana Feijoo , Oliveira Ana Claudia Colombo de , Moresco Rafael Noal , Sauzem Patricia Dutra , Manfredini Vanusa , Machado Michel Mansur , Piccoli Jacqueline da Costa Escobar
Published: August 2019

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Avaliação das atitudes dos profissionais do Consultório na Rua frente ao uso e abuso de álcool e outras drogas
Authors: Davel Juliana Oliveira , Do Amaral Tatiana Rodrigues , Siqueira Marluce Mechelli de
Published: August 2019

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Concordância entre parâmetros antropométricos de obesidade na avaliação do risco cardiovascular em uma amostra de funcionários do setor de alimentação coletiva
Authors: Ferriani Lara Onofre , Martins Lisandra Vanessa , Pizetta Letícia Calvi , Silva Daniela Alves
Published: August 2019

Agreement between anthropometric parameters of obesity in cardiovascular risk assessment in food service workers
Fratura de agulha de sutura encontrada em espaço parafaríngeo Fracture of suture needle found in parapharyngeal space
Authors: Gross Dayane Jaqueline , Martins Luciana Dorochenko , Andreis Jéssica Daniela , Bortoluzzi Marcelo Carlos , Gonçalves Ramon César Godoy
Published: August 2019

Introduction: Among the specialties, the maxillofacial surgery is one in which the professional is more exposed to accidents and complications. Thus, once the surgery is indicated, it is important to have a detailed surgical planning based on the physical examination and imaging examinations, in order to avoid iatrogenies. Objective: To report an atypical and rare case of suture needle fracture aftersuturing in minor oral surgery. Case report: Female patient, with the presence of a suture needle in parapharyngeal space, removed by surgical procedure under general anesthesia. Conclusion: The patient progresses well, without complications. Thus, if a fracture occurs, secondary complications can be avoided by promptly sending the patient to a specialized hospital to prevent the movement offragments in deeper tissue regions.
Structure and Sequence Based Analysis of Pullulanases: Understanding Dual Catalytic Mechanism
Authors: Vashishtha Shubham , Barwal Tushar S. , Bansal Saurabh
Published: August 2019

Background:

Starch processing requires a combination of enzymes with other chemical
and physical processes, which increases cost and time. Enzymes used in these processes have a
characteristic (α/β)8 barrel domain architecture, although, show variable activity. Pullulanase type
1 and isoamylase act on α-1-6 linkage, amylase on α-1-4 linkage whereas pullulanase type 2 acts
on both α-1-6, and α-1-4 linkages of starch.

Objective:

This article focusses on elucidating the importance of sequence and structural-based
differences in pullulanase, that may lead to its dual catalytic nature.

Methods:

Initially, sequences and structures of pullulanase type 1, pullulanase type 2, amylase and
isoamylase were retrieved from the database (NCBI and PDB). Homology modelling using
SWISS-MODEL and PHYRE2 was carried out for predicting the structure of the enzymes with
unavailable structures. Further, the modelled structures were validated using ANOLEA, Verify 3D
and PROCHECK, structures with high confidence value were selected and used for analysis.
Finally, the selected structures were compared by using PDBefold, and their domain alignment and
analysis was performed manually using Pymol.

Results:

Modelled structures of pullulanase and isoamylase were validated and selected based on
the confidence score. Comparative analysis of complete structures low similarity between the
enzymes, although, domain analysis showed good similarity. Moreover, alignment of catalytic site
residues showed high similarities with the change in orientation of critical site residues (HIS 242,
ASP 347 and GLN 375).

Conclusion:

The change in orientation of active site residues along with the absence or presence of
few residues might play a crucial role in imparting dual functionality.
Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts
Authors: Deep Aakash , Verma Mitali , Marwaha Rakesh K. , Sharma Arun K. , Kumari Beena
Published: August 2019

Aim:

The objective behind this present work is the development and characterization of
silver nanoparticles from Dalbergia sissoo leaf extracts and the analysis of anticancer activity.

Methods:

Silver nanoparticles were prepared by using the aqueous solution of Dalbergia sisoo
leaf extract and silver nitrate. The formation of nanoparticles was determined by the color change
during the preparation of plant extract to metal ion in a fixed ratio. The prepared nanoparticles
were then characterized by TEM, FTIR, DLS, XRD, and SEM. Silver nanoparticles were also
evaluated for anticancer activity.

Results:

Synthesized silver nanoparticles were having good anticancer activity against MCF 7
cancer cell line as compared to the standard drug Doxorubicin.

Conclusion:

The particle size of nanoparticles was found to lie in the range of 10 to 50 nm.
Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis
Authors: Kundu Paromita , Singh Deepika , Singh Abhalaxmi , Sahoo Sanjeeb K.
Published: August 2019

The panorama of cancer treatment has taken a considerable leap over the last decade with the
advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an
emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single
probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the
same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the
way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific
biological system. This review presents an overview of the nano theranostics approach in cancer management
and a series of different nanomaterials used in theranostics and the possible challenges with future directions.
Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease
Authors: Singh Anurag K. , Singh Santosh K. , Nandi Manmath K. , Mishra Gaurav , Maurya Anand , Rai Arati , Rai Gopal K. , Awasthi Rajendra , Sharma Bhupesh , Kulkarni Giriraj T.
Published: August 2019

Berberine (a protoberberine isoquinoline alkaloid) has shown promising pharmacological activities, including analgesic, anti-inflammatory, anticancer, antidiabetic, anti-hyperlipidemic, cardioprotective, memory enhancement, antidepressant, antioxidant, anti-nociceptive, antimicrobial, anti- HIV and cholesterol-lowering effects. It is used in the treatment of the neurodegenerative disorder. It has strong evidence to serve as a potent phytoconstituent in the treatment of various neurodegenerative disorders such as AD. It limits the extracellular amyloid plaques and intracellular neurofibrillary tangles. It has also lipid-glucose lowering ability, hence can be used as a protective agent in atherosclerosis and AD. However, more detailed investigations along with safety assessment of berberine are warranted to clarify its role in limiting various risk factors and AD-related pathologies. This review highlights the pharmacological basis to control oxidative stress, neuroinflammation and protective effect of berberine in AD, which will benefit to the biological scientists in understanding and exploring the new vistas of berberine in combating Alzheimer’s disease.
Production of Citric Acid from the Fermentation of Pineapple Waste by Aspergillus niger
Authors: Ayeni Augustine. O. , Daramola Michael O. , Taiwo Olugbenga , Olanrewaju Omowonuola I. , Oyekunle Daniel T. , Sekoai Patrick T. , Elehinafe Francis B.
Published: August 2019

Background:

Citric acid, aside its uses as a cleaning agent, has varied applications in the chemical, pharmaceutical, and food industries. A biotechnological fermentation process is one of the easiest ways to satisfy the demands for this useful commodity.

Methods:

The fermentation of pineapple waste byAspergillus nigerfor the production of citric acid was investigated in this study. STATISTICA 8 release 7 (Statsoft, Inc. USA) statistical software was used for the design of experiments, evaluation, and optimization of the process using the central composite design (CCD), a response surface methodology approach. Lower-upper limits of the design for the operating parameters were temperature (25-35oC), fermentation time (35-96 h), pH (3-6), methanol concentration (1-7%) and glucose (15-85 g/L). Twenty-seven duplicated experimental runs were generated for the CCD route.

Results & Conclusion:

The optimal operating conditions were validated at 38 g/L of glucose concentration, 3% (v/v) of methanol, 50 h of fermentation time, pH of 4.3 and temperature of 30oC which yielded15.51 g/L citric acid. The statistical significance of the model was evaluated using a one-way analysis of variance. The validated predicted response values obtained from the statistical model showed close relationships with the experimental data.
Parents Knowledge and Awareness of their Children’s Oral Health in Riyadh, Saudi Arabia
Authors: Hamasha Abed A-H. , Rasheed Salman J. , Aldosari Mohammed M. , Rajion Zainul
Published: August 2019

Objective:

To assess the parents’ knowledge and awareness of their children’s oral health in Riyadh, Saudi Arabia.

Methods:

The study was a cross-sectional analytical study of Saudi parents. A self-administered questionnaire was collected from 324 parents in public parks and malls. In addition to the demographic questions, parents’ knowledge about the number of primary teeth, tooth brushing, best time of dental visits, the meaning of plaque and calculus, the importance of fluoride, the relationship between primary and permanent teeth and the effect of oral health on general health were questioned. Data analysis included descriptive statistics and one-way analysis of variance and Bonferroni tests to assess differences in the mean number of correct answers among demographic categories. A p-value of 0.05 was set at a significant level.

Results:

The percentages of correct answers ranged from 26% to 75% depending on the type of questions. Only 26-28% could identify the number of primary teeth and the duration of teeth brushing. About one-third of parents knew the time of the first dental visit and the definition of plaque and calculus. Between 63-75% of parents believed that primary teeth can affect permanent teeth and mouth problems can affect general health. On average, 59.2% of participants provide incorrect answers about their children’s oral health. The numbers of correct answers were significantly increased by increasing education and income.

Conclusion:

Parents' knowledge and awareness of oral health among Saudi parents were poor. Special attention should be given to parents with low socioeconomic status who need to be educated about children oral health more.
A Rare Case of Co-occurrence of Emphysematous Cystitis and Emphysematous Myositis in a Haemodialysis Patient
Authors: Y.J. Anupama , S. Chandrasekhar
Published: August 2019

Urosepsis presents an unusual diagnostic challenge in chronic dialysis patients who often are anuric. This leads to atypical presentations, delayed diagnosis and poor outcome. Here we present a case of an elderly diabetic patient with chronic kidney disease on maintenance haemodialysis who presented with lower limb pain initially and had no urinary complaints. The evaluation revealed the presence of extensive emphysematous pyelonephritis, cystitis and myositis. The unusual presentation is discussed along with a relevant review of the literature.
Investigation of THz Radiation from Longitudinal Optical Phonon- Plasmon Coupling in p-i-n Diodes
Authors: The Nguyen P.
Published: August 2019

Background:

Terahertz radiation (THz) in infrared domain at room temperature has
many applications in science and technology, especially in the technology of analyzing and processing
image. This paper introduces a relatively simple method to investigate the Terahertz radiation
from the coupling of Longitudinal Optical (LO) phonon and coherent plasmon in p-i-n diode
structure. The frequency spectra are found from the Fast Fourier Transform (FFT) of the voltage
between two neighboring points in the insulating region of this diode. Numerical calculations have
been applied for GaAs semiconductor device with the photo-excited carrier density ranging from
17 1.0×10 cm-3 to 18 3.0×10 cm-3 and the insulating layer size of 500 nm.

Methods:

In order to study of the coupling of LO phonon in p-i-n diode based on the EMC simulations,
the equation of density vibration is solved simultaneously with the simulation of carrier dynamics,
this is performed with spatial resolution of 1A° and time resolution of 0.20 fs . We solve
the Poisson’s equation to derive the potentials along the x-axis in both cases with and without
taking into account the coupling. The frequency spectrum derived from the FFT of the voltage of
two layers separated by a distance 10 nm in insulating layer (i).

Results:

The frequency spectrum derived from the Fourier transform of the voltage between two
neighboring points with and without LO phonon–plasmon coupling is shown. We can easily observe
the existence of the modes which are close to the frequency values of bulk semiconductor. It
should be noted that, our calculations are reasonable agreement with experiments measured by the
Ibanez et al in Phys. Rev. B 69 (7), 075314 (2004).

Conclusion:

In this paper, we present a relatively simple approach to investigate the THz radiation
from the coupling of LO phonon-plasmon in p-i-n diode structure by taking the FFT of the voltage
of two neighboring points in insulating semiconductor region. The voltage is calculated through
the electric potentials which relate to the charge density via Poisson’s equation. Numerical calculations
have been performed for GaAs semiconductor device with carrier density ranging from
17 1.0×10 cm-3 to 18 3.0×10 cm-3. Our simulations calculations show that with appropriate photoexcited
carrier density, two strong coupling LO phonon-plasmon coherent modes are appear.
Synthesis, Characterization andin vivoEvaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin
Authors: Parashar Ashish K. , Patel Preeti , Gupta Arun K. , Jain Neetesh K. , Kurmi Balak Das
Published: August 2019

Background:

The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin.

Methods:

For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared.

Results:

PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances.

Conclusion:

Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.