bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacology and Adverse Events of Emergency-Use Authorized Medication in Moderate to Severe COVID-19
Authors: Hsu Jen-Yu , Mao Yan-Chiao , Liu Po-Yu , Lai Kuo-Lung
Published: September 2021

Some effective drugs have been approved or issued an Emergency Use Authorization for the treatment of COVID-19 in hospitalized patients, but post-market surveillance is warranted to monitor adverse events. We reviewed clinical trials and case reports in patients with moderate-to-severe COVID-19 infection who received remdesivir, baricitinib, tocilizumab, or sarilumab. The drug-specific pharmacokinetics, toxicity, and drug interactions are summarized in this study. Remdesivir and baricitinib are small-molecule drugs that are mainly metabolized by the kidneys, while tocilizumab and sarilumab are monoclonal antibody drugs with metabolic pathways that are currently not fully understood. The most common adverse events of these drugs are alterations in liver function, but serious adverse events have rarely been attributed to them. Only a few studies have reported that remdesivir might be cardiotoxic and that baricitinib might cause thromboembolism. Biological agents such as baricitinib, tocilizumab, and sarilumab could inhibit the pathway of inflammatory processes, leading to immune dysregulation, so the risk of secondary infection should be assessed before prescribing. Further recognition of the pathogenic mechanism and risk factors of adverse events is essential for optimizing treatment strategies.
Histological Changes in Renal, Hepatic and Cardiac Tissues of Wistar Rats after 6 Weeks Treatment with Bipyridine Gold (III) Complex with Dithiocarbamate Ligands
Authors: Badar Ahmed , Ahmed Ayesha , Al-Tamimi Dalal M. , Isab Anvarhusein A. , Altaf Muhammad , Ahmed Sania
Published: September 2021

Bipyridine gold (III) dithiocarbamate compounds are Gold-III complexes with promising cytotoxic properties. In this study, the subacute toxicity of a Gold (III) complex with dithiocarbamate ligand was evaluated. In the acute toxicity component, an initial LD50 (38.46 mg/kg) was calculated by the administration of 50, 100, 200, 400, and 800 mg/kg of the compound to five groups of rats, respectively (n = 4 each). The sixth group was the control. The sub-acute toxicity component comprised the control group A (n = 6) and the study groups B (n = 10) and C (n = 4), which were administered 1 mL distilled water, 1/10 LD50 (3.8 mg/kg), and 1/5 LD50 (7.6 mg/kg), respectively, daily for 6 weeks. The alive animals were then sacrificed. Autopsy; preservation of renal, hepatic and cardiac tissue in buffered formalin; histopathological processing; microscopic evaluation; and comparison with the controls were sequentially conducted. In the subacute toxicity study at dosages of 3.8 mg/kg and 7.6 mg/kg, the renal tubules remained unaffected with no necrosis or vacuolization. Mild to moderate renal interstitial, hepatic capsular, lobular and portal inflammation along with mild focal hepatic vacuolization were present. At 3.8 mg/kg, the cardiac muscle fibers were unremarkable in 80% (n = 8) of the specimens, with mild focal hyalinization in 20% (n = 2) of the specimens. The same was observed in 50% (n = 2) of the specimens at 7.6 mg/kg. Variable congestion was evident in all of the groups. In the subacute toxicity study, the absence of renal tubular necrosis or vacuolization, the presence of mild inflammatory hepatic and renal alterations, and predominantly unremarkable cardiac muscle fibers suggest that Bipyridine gold (III)-dithiocarbamate is safe in animal studies and is a potential candidate for clinical trials.
How Microgels Can Improve the Impact of Organ-on-Chip and Microfluidic Devices for 3D Culture: Compartmentalization, Single Cell Encapsulation and Control on Cell Fate
Authors: Argentiere Simona , Siciliano Pietro Aleardo , Blasi Laura
Published: September 2021

The Organ-on-chip (OOC) devices represent the new frontier in biomedical research to produce micro-organoids and tissues for drug testing and regenerative medicine. The development of such miniaturized models requires the 3D culture of multiple cell types in a highly controlled microenvironment, opening new challenges in reproducing the extracellular matrix (ECM) experienced by cells in vivo. In this regard, cell-laden microgels (CLMs) represent a promising tool for 3D cell culturing and on-chip generation of micro-organs. The engineering of hydrogel matrix with properly balanced biochemical and biophysical cues enables the formation of tunable 3D cellular microenvironments and long-term in vitro cultures. This focused review provides an overview of the most recent applications of CLMs in microfluidic devices for organoids formation, highlighting microgels’ roles in OOC development as well as insights into future research.
Modeling the Producibility of 3D Printing in Polylactic Acid Using Artificial Neural Networks and Fused Filament Fabrication
Authors: Meiabadi Mohammad Saleh , Moradi Mahmoud , Karamimoghadam Mojtaba , Ardabili Sina , Bodaghi Mahdi , Shokri Manouchehr , Mosavi Amir H.
Published: September 2021

Polylactic acid (PLA) is a highly applicable material that is used in 3D printers due to some significant features such as its deformation property and affordable cost. For improvement of the end-use quality, it is of significant importance to enhance the quality of fused filament fabrication (FFF)-printed objects in PLA. The purpose of this investigation was to boost toughness and to reduce the production cost of the FFF-printed tensile test samples with the desired part thickness. To remove the need for numerous and idle printing samples, the response surface method (RSM) was used. Statistical analysis was performed to deal with this concern by considering extruder temperature (ET), infill percentage (IP), and layer thickness (LT) as controlled factors. The artificial intelligence method of artificial neural network (ANN) and ANN-genetic algorithm (ANN-GA) were further developed to estimate the toughness, part thickness, and production-cost-dependent variables. Results were evaluated by correlation coefficient and RMSE values. According to the modeling results, ANN-GA as a hybrid machine learning (ML) technique could enhance the accuracy of modeling by about 7.5, 11.5, and 4.5% for toughness, part thickness, and production cost, respectively, in comparison with those for the single ANN method. On the other hand, the optimization results confirm that the optimized specimen is cost-effective and able to comparatively undergo deformation, which enables the usability of printed PLA objects.
Optimization of Electrochemical Visualization of Latent Fingerprints with Poly(Neutral Red) on Brass Surfaces
Authors: Broncová Gabriela , Slaninová Tereza , Trchová Miroslava , Prokopec Vadim , Matějka Pavel , Shishkanova Tatiana V.
Published: September 2021

This study is focused on the visualization of latent fingerprints on brass surfaces using the method of electrochemical deposition of a polymer film based on poly(neutral red) (PNR). The experiment included (i) optimization of conditions of electrochemical deposition of PNR on brass surfaces, (ii) ATR-FTIR spectroscopic characterization of PNR-modified substrates, and (iii) identification of characteristic details on visualized fingerprints on fired brass cartridges. For electrochemical visualization, it is necessary to keep in mind both kind and “story” substrates. Experimental findings showed that electrochemical visualization carried out on brass plates is a step forward before known findings described in the literature and gives simultaneously a new approach for criminalists in the fight against crime.
A Study on the Hydrolysis of Urea Contained in Wastewater and Continuous Recovery of Ammonia by an Enzymatic Membrane Reactor
Authors: Yahya Mukhtar Nuhu , Gökçekuş Hüseyin , Orhon Derin , Keskinler Bülent , Karagunduz Ahmet , Omwene Philip Isaac
Published: September 2021

1. Background: Urea is the main product of the nitrogenous breakdown of protein metabolism in mammals. In this study, process intensification for enzymatic hydrolysis of urea by urease enzyme (jack bean urease) was examined in a membrane reactor. 2. Methods: Batch and continuous enzymatic hydrolysis reactions were performed at different substrate concentrations to determine the digestibility and affinity of the substrate with that of the enzyme. The hydrolysate samples were obtained by an optimized continuous enzyme membrane reactor (EMR) coupled with an ultra-filtration membrane (250 kDa). Feed concentration varied from 100 to 500 mg/L. Laboratory experiments were conducted at room temperature (20 ± 1 °C), with a flow rate of 20 mL/min, urease concentration of 0.067 g/L, ionic strength (I = 0, 0.01, 0.05), and ammonium nitrogen addition of (0, 100 mg/L, 200 mg/L, 500 mg/L). Moreover, the effect of ionic strength, ammonium nitrogen concentration, feed concentration, and enzyme concentration on urea hydrolysis was examined. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDAX) analysis were used to identify the physicochemical properties as well as the elemental composition of the Ultra-Filtration membrane used in this study. 3. Results: The study revealed that higher ionic strength and higher concentrations of NH4SO2 and ammonium nitrogen (NH3-N) inhibithydrolysis of urea by reducing the urease enzyme activity in the system over time. 4. Conclusions: Herein, a sustainable alternative for the conversion of urea to ammonia by utilizing urease in an EMR was demonstrated.
MADURACIÓN DEL FRUTO Y MORFOMETRÍA DE SEMILLAS DE Genipa americana L. EN EL DEPARTAMENTO DEL QUINDÍO
Authors: Ramírez-Morales Sandra Viviana , Orozco-Cardona Andrés Felipe
Published: September 2021

Se evaluó el estado de maduración del fruto y la variabilidad morfométrica de las semillas de Genipa americana procedentes de 6 poblaciones de la zona cálida del departamento del Quindío. Se colectaron 60 frutos maduros de los cuales se tomaron 600 semillas para evaluar su morfometría. El estudio se desarrolló en el laboratorio de Biotecnología del Centro de Estudios e Investigaciones de Biodiversidad y Biotecnología de la Universidad del Quindío (CIBUQ). Se valoraron características organolépticas y morfométricas en los frutos; además de los caracteres: Peso, largo, ancho, grosor, relación largo-ancho, volumen y forma en las semillas, siguiendo la metodología de Iglesias, Mora y Casas (2005), con algunas modificaciones. Se calculó el coeficiente y factor de variación y se realizó un análisis de componentes principales mediante el programa Matlab (Versión 7.0). Se encontró que los frutos de la especie presentan variación en tamaño, peso y número de semillas; alto coeficiente y factor de variación en la forma de las semillas, varianza del 38% en el primer componente principal y alta variabilidad intrapoblacional en volumen, peso y largo de las semillas. Los frutos y semillas de la especie presentan medidas superiores a lo reportado por otros autores. Es probable que factores genéticos afecten el tamaño peso y forma de la semilla; aunque la variación proviene principalmente de factores ambientales, que asimismo influencian la sobre vivencia, el crecimiento y la reproducción.
CONCEPTO DE CLASE DE EDUCACIÓN FÍSICA EN LOS ESTUDIANTES DEL PROGRAMA DE LICENCIATURA EN EDUCACIÓN FÍSICA DE LA UNIVERSIDAD DEL QUINDÍO
Authors: López-García Jorge Alberto , Murillo Johanna Andrea , Sánchez-Cadavid Jairo Antonio , Posada-Molina Mauricio , Galíndez Jhon Hermógenes
Published: September 2021

El objetivo de este estudio fue el de indagar acerca del concepto de “Clase de educación física” que tienen los estudiantes del programa de Licenciatura en Educación Física y Deportes de la Universidad del Quindío el cual, partiendo de la comprensión de ese concepto de clase en los estudiantes que cursan los semestres del I al III de nuestro programa, servirá de referente teórico para apalancar los procesos académicos de nuestro programa o plan curricular, en especial en la búsqueda de ese estado del arte que siempre nos tiene en deuda y sobre todo acerca de la concepción que presenta para nuestros estudiantes la clase de educación física. Este proyecto se enmarca en el terreno de los jóvenes universitarios, ya que la población que hace parte de este estudio está en edades entre los 15 a los 19 años de edad, por lo tanto las nociones o interpretaciones respecto al concepto que tienen los estudiantes frente a la clase de Educación Física, ayuda al rompimiento de concepción es tradicionales de la clase y permite la puesta en discusión de otras miradas que permita pensarse la clase de otra manera. En un contexto como lo es la Universidad y en las edades en que se desarrolló el estudio, se hace de vital importancia y actual, permitir el repensar las practicas y reconocer los imaginarios de los jóvenes de nuestra región en campo de la educación física y los deportes que toman la decisión de participar de nuestro proyecto de vida académico.
ESTRUCTURA DE LAS REDES SOCIALES DE LA POBLACIÓN MAYOR DE 60 AÑOS EN CONTEXTOS URBANOS DE POBREZA, DEL DEPARTAMENTO DEL QUINDÍO
Authors: Quintana-Urrea Leonardo Iván , Gómez-Santos César Augusto
Published: September 2021

El propósito de este artículo es presentar los resultados de la investigación del proyecto Redes sociales de la población mayor de 60 años en contextos urbanos de pobreza del departamento del Quindío que enfatiza en la identificación y análisis de la estructura de las redes sociales y las condiciones de vida que presenta esta población, en relación con su tamaño; distancia física, social y psicológica; frecuencia y tipos de contactos; reciprocidad. Desde estos presupuestos, es posible concluir que las redes sociales del Adulto Mayor Pobre en contextos urbanos, juegan un rol determinante en relación con el apoyo que reciben las personas mayores, de parte tanto de la red familiar comodelanofamiliar.Losdatosdemuestranqueunagrancantidaddeellossonreceptoresdealgúntipodeayuday son excepcionales los casos en que, teniendo vínculos con familiares o con amigos y vecinos, no obtienen apoyo. Lo cual demuestra cómo la solidaridad y el soporte mutuo reemplazan o mitigan la ausencia de los recursos necesarios quelespermitanaccederalosbienesyserviciosquerequierenparasubsistir.Seconfirmaquelasmujeressonlasque mayor cantidad de apoyo reciben; pero que también son ellas las que más ayudas dan dentro de las redes sociales familiares,lasnofamiliaresylaredformal.
PEDAGOGICAL TRADE AS A MAEN OF EFFECTIVE REALIZATION OF TEACHING ON BASIS OF RESEARCHES
Authors: Divinska Natalia
Published: September 2021

Role of the research students’ activities of as a factor of modernization of contemporary education is stressed in the article, and its positive impact on the whole educational process was defined, and the educational experience was highlighted.Based on the analysis of scientific, pedagogical and methodological literature and current educational experience of organization of students’ research work in the universities of Ukraine, the nature and content of the concept of the students’ readiness to research work are stated. Also the components and conditions of their formation were systematized, the phenomenon of pedagogical skills of higher school teachers’, its characteristics and structure were observed.It’s proved that at the current state of higher teacher’ education development is to be analyzed and modified while professional training systems of teaching staff in Ukraine. Such an analysis, of course, allows preserving all of the valuable long-term teaching  practice  of  professional  psycho-pedagogical  disciplines  teaching  in  our country and enriches its valuable achievements the methods of high school, which were influenced by new educational trends.For successful operation in higher teacher education institution the lecturer is required to navigate quickly and switch attention, to assess the situation from different sides, using a set of techniques and methods of influence, using the educational equipment effectively, perceive phenomena and processes of reality to be able to respond to the real situation, analyze ratio "goal - means - results" due to the situation chosen, to form a creative atmosphere, to be a leader, to overcome the language barrier, to be a speaker and organizer, a director-producer, an actor, to play with the audience. All this is possible due to realization of conditions of effective pedagogical skills formation, because any modern technology in the hands of a lecturer with different pedagogical skill levels will produce a different result.Analysis conducted, it shows that further studies requires the elaboration of the questions of the essence and structure of teacher’s readiness to research activity, conditions for the formation of readiness of students to research activities and implementation of research in the educational process of higher educational institutions of Ukraine.
INDIVIDUALLY-DIFFERENTIATED APPROACH TO PERSONAL DEVELOPMENT STUDENTS IN THE PROCESS OF ETNODYZAYNERSKOYI
Authors: Rudenchenko Alla
Published: September 2021

The article analyzes the need to introduce based on humanistic principles, innovation, personality-oriented educational model that would reflect the features of modern social and cultural space. Organization of scientific and educational process in higher educational institutions of art should be based on modern developments in the field of art education and art pedagogy, active use of the traditions of folk culture. The use of multiple intelligence theory of American psychologist Howard Gardner, will allow to increase the quality level of education, strengthen the relationship with the educational process practitioners and make spiritual component in the educational process of students of art schools. New Millennium and the current difficult socio- economic situation need to develop new conceptual models of learning and education. This model of education can be developed based on a new integrative philosophical and psycho-pedagogical field of scientific knowledge. Socio-economic and spiritual changes occurring in our country need most complete development of man as the highest social value.
THEORETICAL ASPECTS OF INFORMATIONAL-COMMUNICATIVE TECHNOLOGIES USING WHILE UPGRADING OF PRIMARY SCHOOL TEACHERS’ QUALIFICATION
Authors: Kolizhuk Anna
Published: September 2021

The state of education in the country affects the lives of its people, their wellbeing and personal development. Today the role of education is quite different from the one in previous centuries. Preparation for life and work in a rapidly changing environment comes at the forefront.Education should focus on active, developing technologies, aimed on to development of logical thinking operations (analysis, synthesis, comparison, systematization, generalization, specification, etc.); ability to learn, to make decisions quickly, and to adapt to the conditions of life and labor.Education should be aimed to prospect development of the society. It means that educational institutions must use the latest information technologies. Creation of functional information environment is the main task of modern society. So, the main task is the computerization of educational institutions. Accordingly the teacher’s role in this process is changing. And therefore there is the urgent need of teacher accordance with the new requirements of society. One of the ways of elaboration of this question is the active use of information and communication technologies, which provide wide opportunities for development of professional competence of teachers.The article discusses the role of information and communication technologies in the modern educational process, the state of development of teachers’ skills of using ICT in the system of continuous pedagogical education, organizational and pedagogical conditions for the success of this process.
KEY CONCEPTS OF SELF-CONCEPTION OF ACADEMICIAN NELLY NYCHKALO
Authors: Semenoh Olena
Published: September 2021

On the basis of research and reflection on Nelly G. Nychkalo the article outlines the key concepts of "working man", "a man of culture", "patriotic person" in terms of professional development and self-identity. According to V. Kremen reasons, the concept of self-conception is considered to indicate the mental representation of himself, displaying of meta-individual world of personality in her consciousness and imaginations of himself on which she gives birth to a new sovereign image, determines the prospects of her own potential. Ideas of Zyazyun are taken into account, who set in the center of educational mastery "I"-Concept, experience, communication, personality, its orientation, affect, will and intelligence. Attention is focused on intelligence, intelligence, spiritual elitism, open personality Nelly Nychkalo man as standard pedagogical work.It was found that the characteristics of the concept "man of work" N.Nychkalo enriches by the analysis of the concepts of "human capital", "continuous education", "quality lifelong education", which mostly provides professional competitiveness, creates a need for constant self-identity through formal, non-formal and informal education. It is proved that a person of culture is spiritually rich, humane, creative person, dedicated by her work and captured by it, has developed the desire to do Good, Truth, Hope. We consider the concept of "patriotic man," moral values and spiritual content of which make the culture of the nation.
GENETICS OF PHOBIC DISORDERS
Authors: Pomohaibo V. , Berezan O. , Petrushov A.
Published: September 2021

At present time, on the basis of genome-wide association studies (GWAS), several authors found linkage of phobic disorders with certain regions of chromosomes – 3q26 (agoraphobia), 14q13 (specific phobias), 16q21 (social phobias), 16q22 (social phobias) and 4q31-q34 (phobic disorders). We propose 19 genes that are localized in these regions and are expressed in the brain: PRKCI, CLDN11, EIF5A2, TNIK, CLCN3, CPE, GLRB, GRIA2, NEK1, NPY2R, NPY5R, RAPGEF2,  TRIM2, SMAD1, ADGRG1, BEAN1, CDH8, DOK4 and KATNB1. Therefore, these genes may be investigated as candidate genes of phobic disorders.

Various sources propose 26 potential candidate genes of phobic disorders. Finnish geneticist J. Donner carries out a meta-analysis to study the 8 most probable among them and corroborates statistical validity only for 4 genes: ALAD, CDH2, EPB41L4A and GAD1. First three genes are involved in the social phobias, and fourth is involved in whole phobic disorders.

Phobias are heterogeneous and multifactorial diseases. To understand the biological mechanisms of such disorders, to create effective methods for their prevention and treatment, there are needed further intensive molecular genetic studies of these disorders on sufficiently large samples and corroborating these results by other authors.
Análisis químico proximal de granos y harina de Pajuro (Erythrina edulis) para elaborar bebidas proteicas
Authors: Espinoza Córdova Gaby , Rojas Rosario , Espinoza Montesinos Francisco
Published: September 2021

El  presente  trabajo  contribuye  en dar a conocer al Pajuro proveniente de   Oxapampa   como   una   buena fuente   de   proteína   vegetal   con el  fin  de  fomentar  su  consumo  y ayudar   a   reducir   los   niveles   de desnutrición   de   la   población.   El objetivo   de   esta   investigación   es conocer   la   composición   químico- proximal de los granos y la harina de Pajuro  proveniente  de  la  provincia de   Oxapampa   y,   a   base   de   la última,  proponer  la  elaboración  de una  bebida  proteica  con  sabor  a chocolate degustada y evaluada por un  panel  de  cata  no  entrenado.  La metodología empleada fue de diseño experimental, de tipo preexpeimental con un nivel de estudio de caso con una sola medición. Como conclusión se pudo determinar que los granos de Pajuro (Erythrina edulis) y la harina de este en base seca están compuestos por       carbohidratos,       proteínas, cenizas,  fibra  y  grasa,  y  es  rica  en oligoelementos   y   macrominerales beneficiosos para las personas.
SITUAÇÃO DA LEISHMANIOSE VISCERAL CANINA (LVC) NO ESTADO DE SÃO PAULO.
Authors: Jabur Lot Rodrigues Nássarah , Prestes Di Pietro Benetton Rafaella , Neuwirt Oliveira Natalie , Manzini Suzane , Langoni Helio
Published: September 2021

A leishmaniose visceral (LV) é uma enfermidade zoonótica transmitida pelo vetor flebotomíneo Lutzomyia longipalpis, conhecido popularmente como ‘’mosquito-palha’’. No meio urbano, o principal reservatório é o cão doméstico. Apresenta-se em plena expansão pelo estado de São Paulo, com 76 munícipios com transmissão canina e humana, 54 municípios silenciosos receptivos vulneráveis, no ano de 2015, e com treze casos humanos e dois óbitos registrados no primeiro trimestre do ano de 2019. O diagnóstico da Leishmaniose Visceral Canina (LVC) pode ser realizado através de técnicas indiretas ou diretas. O protocolo oficial utiliza a triagem pela técnica Dual Plath Platform (DPP) e a confirmação pela técnica de ensaio imunocromático (ELISA). O tratamento é realizado com o medicamento MillteforanTM, o qual possibilita apenas a cura clínica do animal. A eutanásia, por sua vez, permanece como medida de controle controversa. A prevenção continua figurando como a melhor solução para a transmissão dessa doença.
EDUCAÇÃO SANITÁRIA COM FOCO NA SEGURANÇA DE ALIMENTOS: UMA ABORDAGEM PARA CRIANÇAS
Authors: Nunes de Moraes Gustavo , Fwu Shing Teng , Rosa Rodrigues de Souza Carolina , Costa Danelon Giovanni , Tiemi Hioka Luciana , Teston Campanha Rafaela , Vizzuso Maria Helena , Barbosa da Silva Juliana , Rocha Gabrielle dos Santos , Santiago Velame Marise , Pereira Juliano Gonçalves
Published: September 2021

As doenças transmitidas por alimentos (DTAs) são definidas como enfermidades infecciosas ou tóxicas causadas pelo consumo de alimentos ou água contaminados. Na atualidade, são consideradas um dos maiores problemas mundiais de saúde pública. Dentro do contexto das DTAs, a higiene pessoal e a manipulação inadequada de alimentos no ambiente doméstico têm sido apontadas como importantes fatores de risco para a ocorrência de surtos. Baseado nestas considerações, o presente projeto de extensão universitária foi desenvolvido no intuito de instruir crianças em idade escolar sobre a importância da higiene pessoal e da manipulação adequada de alimentos, de modo que estas disseminem a informação a seus pais e familiares. O projeto foi instituido em uma escola pública do município de Botucatu-SP e atingiu 491 crianças de 5 a 11 anos. As atividades foram aplicadas em três ações prioritárias, sendo elas: 1) Palestra introdutória lúdica e interativa; 2) Gincana com brincadeiras e atividades formativas práticas e; 3) Entrega de certificados de participação e uma cartilha contendo informações e jogos com enfoque nos assuntos abordados, de modo a possibilitar a disseminação das informações para os familiares e amigos dos participantes. Os alunos demonstraram grande interesse pelo assunto, enfatizando a importância dessa abordagem nas escolas. Foi possível promover, portando, educação em saúde de forma prazerosa, de modo a evitar doenças relacionadas à precária higiene pessoal e à manipulação incorreta de alimentos.
ABORDAGEM DA LEISHMANIOSE VISCERAL CANINA (LVC) POR MÉDICOS VETERINÁRIOS
Authors: Santos Ed Wilson , Aoun Moustapha Nathalia , Hoffman Bueno Magdanelo Esther Ligia Laura , Negrão Multari Júlia , Tellaroli Giovanna
Published: September 2021

A Leishmaniose visceral canina (LVC) é uma zoonose de extrema importância na saúde pública, de distribuição mundial, com 90% dos casos registrados no Brasil. É causada pelo protozoário gênero Leishmania e tem como principal hospedeiro o cão doméstico. Para que ocorra a transmissão, é obrigatória a presença do vetor, mosquito hematófago Lutzomyia sp. O diagnóstico da doença é bastante difícil, já que 60 a 80% dos animais soropositivos são assintomáticos e as manifestações clínicas são muito inespecíficas. Após mudanças realizadas pelo Ministério da Saúde, atualmente é permitido realizar o tratamento dos animais positivos para LVC, no qual o medicamento mais aceito é a miltefosina, porém, independente do tratamento, o melhor método contra a LVC é a prevenção. No presente trabalho foi produzido um questionário através da plataforma Google Forms com 14 perguntas englobando a Leishmaniose. Foram coletadas 65 respostas de médicos veterinários de diferentes idades e estados do Brasil.  80% dos veterinários disseram indicar o tratamento do animal em caso de leishmaniose confirmada, enquanto 3,08% ainda indicam a eutanásia. Embora não recomendados, ainda se nota o uso de anfotericina B e antimoniais pentavalentes nos protocolos de tratamento, porém a maioria (75,4%) opta pelo uso da miltefosina, recomendada. A vacinação, embora aceita pela maioria dos veterinários (95,38%), ainda é uma prática pouco utilizada devido à baixa disponibilidade do produto nas clínicas, somente 47,69% tem no consultório. Dentre os veterinários, 95,4% indicam o uso de coleiras de deltametrina 4% como prevenção. Uma boa atuação do médico veterinário é de suma importância para o efeito controle da LV.
Sufism Between Asceticism and Jihad: A Conceptual and Historical Review
Authors: Suratman Junizar . , Fatarib Husnul , Saharuddin Desmadi
Published: September 2021

In the picture of ordinary people, Sufism teaches Zuhud and distances itself from the world in theory and practice. But this is different from reality. Sufism orders in the archipelago also appeared in the vanguard to fight and repel the invaders. The history of Islamic civilization records a series of resistance movements led by Sheikh Sufism with his followers to fight against the Dutch colonialists. For this to become evident to us, we must examine some of their words and actions: Abu Hamid Al-Ghazali wrote his book (Reviving the Sciences of Religion) during the period of the Crusaders victory over the Levant, and the author remembered everything from the works of hearts and did not remember to write a chapter on jihad. We conducted literature studies and verified and interpreted the descriptions in the literature. With a descriptive analysis, the approach is obtained. The conceptual ambiguity that afflicted Sufism regarding the concepts of jihad and the application of Islamic law" played a major role in the emergence of some analyses that suggest Sufism playing a safe alternative to extremist Islamic movements. Therefore, in this article, we try to answer a complex question, which is the degree of The link between the Sufi orders and the concepts of jihad and the application of Islamic law, and is it possible for the Sufi orders to adopt a form of political violence to implement their goals?
Thematic Analysis: Human Resource Management in Verses of The Qur'an
Authors: Sutrisno Andri , Mudarris Mudarris
Published: September 2021

Human resource management is a process of managing human resources or a potential within humans to realize desired goals in groups. In the Qur'an, it is explained that man is the creation of Allah Almighty. Who is perfect from other beings. Management science is part of the social film, so it is very closely related to human resources. The most influential actor in the management process is the man himself. So that human resource management becomes critical in success to achieve the goals aspired by each group. Islam is a religion that provides various solutions for human affairs, especially in the process of human resource management in its holy book, the Qur'an. Thus in this article, researchers use literature research that examines and analyzes books related to human resource management from the perspective of Quranic verses. So it can be concluded that in the management of human resources in the verses of the Qur'an, there are four processes, namely planning, selection and placement, development, and compensation.
Enabling experimental greenhouse for high-tech application
Authors: Rodríguez-Franco Martín Eduardo , Maldonado-Ruelas Víctor Arturo , Villalobos-Piña Francisco Javier , Ortiz-Medina Raúl Arturo
Published: September 2021

This work exposes the conditioning of the zenith greenhouse of the Polytechnic University of Aguascalientes for its conformation as a high-tech entity, through the adaptation of sensors, actuators and a controller, which ensure the supervision of the environmental conditions inside, mainly established by the variables of temperature and humidity. The development and application of a computer graphical interface is presented as an intuitive tool for monitoring and controlling the field devices used, and therefore, the environmental conditions provided or recorded from their activation. Likewise, the use of the open communication standard OPC is demonstrated as an alternative for effective interaction between the LabVIEW software, from which the management interface was developed, and the PLC, used as the system controller. The results achieved provide proof of the adequate operation of the devices adapted in the greenhouse installation, the compilation of the information associated with the performance of their task and the manipulation of their operation or reading, from the graphical interface developed for this purpose.
Systemic review of the context of external financing of MSMEs in Mexico
Authors: Jiménez-Rico Artemio , Gutiérrez-Rangel Héctor Fabián , Galván-Zavala Karina
Published: September 2021

MSMEs are a key component for the economic and social development of countries, in Mexico they generate approximately 70% of jobs and contribute around 35% of GDP. There is great empirical evidence that shows that the lack of financing affects the economic growth of companies. Microenterprises are those that face the most external financing restrictions and indicate that high interest rates are their main limitation for not accessing external financing, therefore, they are the most affected in their economic growth. The objective of this research is to carry out a systemic review of the context of external financing of MSMEs in Mexico. The results infer that it is urgent to implement adequate public policies to strengthen the financial system and facilitate access to external financing under the best conditions for MSMEs to improve their competitiveness and economic growth.
Business empowerment of women in the Mypes. Francisco I. Madero Case
Authors: Trejo-Encarnación Patricia , Hernández-Gómez Diana , Blancas-Olvera Zoraida
Published: September 2021

Objectives. The objective of this work is to focus on the presence of women in the Mypes of the Municipality of Francisco I Madero, their impact on the social, economic and family environment. Methodology. A quantitative instrument is used to evaluate and analyze the management of women as directors of the Mypes of the municipality and make a contrast with the operation of their male counterpart. Contribution. The contribution of this document is the exploration of the female gender in the management of companies, to investigate if there is inequality and inequality of gender and to inquire about the business empowerment of women and their entrepreneurial capacity to direct, control and achieve the profitability of Mypes.
Wall thickness determination study for a plastic injection barrell due to the internal pressure
Authors: RODRÍGUEZ-DAHMLOW Jesús E. , CONTRERAS-LOPÉZ David , FUENTES-RAMÍREZ Rosalba , MURILLO-YAÑEZ Luis E.
Published: September 2021

The use of Plastics is a very common activity nowadays, there are many different types of Injection Machines varying in size, the capacity of the material to inject, one of the main machines classifications is due to the injection pressure. One of the things to consider when the designing process is carried out is the factor of safety, this factor helps designers to avoid possible failures in mechanical elements of mechanisms, it provides a safety margin that aims to protect against any unexpected incident. The advantage of Simulation is that allows us to predict the behavior of elements under stress. In the Injection Process, barrels are elements subject to high pressure. This encourages analyzing wall thickness to find a suitable barrel wall thickness. The present study is focused on the design of the wall thickness, seeking reduce machining time that are required when producing the barrels that may be needed and to select the proper commercial barrel size reducing material waste.
Effect of induction heating on Vickers and Knoop hardness of 1045 steel heat treated
Authors: MARTÍNEZ-VÁZQUEZ J. Merced , RODRÍGUEZ-ORTIZ Gabriel , HORTELANO-CAPETILLO J. Gregorio , PÉREZ-PÉREZ Arnulfo
Published: September 2021

AISI 1045 steel is a steel of medium carbon, widely used in machinery, the automotive industry, and the food industry, among others. Therefore, to fulfill its purpose, it is necessary to improve its mechanical resistance, wear resistance and resistance to fatigue through different surface heat treatments. Variables such as heating time and hence speed affect the thickness of the hardened layer and the microstructural characteristics of the area affected by heat treatment. The inspection of the transformation of phases during the treatment and the thickness of the boundary layer is generated by determining the hardness of the material, whose procedure is subject to the ASTM E92-17 and E384-17standards, which establish the methodology to be followed. Therefore, the objective of this work is to quantify the effect of three heating times at 1123 K on the hardening of AISI 1045 steel and the regularity of the hardened layer to ensure its functionality as a component subjected to friction, in addition to developing a table of equivalences between the Knoop (HK), Vickers (HK) and Rockwell C (HRC) hardness scales.
Statistical evolution of clinical laboratories in patients admitted to the CECCS with SARS-COV-2
Authors: Yañez Vargas Juan Israel , Prieto García Daniela , Doñate Álvarez Andrea Abigail , Domínguez Joel Quintanilla
Published: September 2021

The evolution of the SARS-CoV-2 Virus in recent months in the world and especially in Mexico has also created changes in the patient’s treatment and their laboratory studies, as is the case of patients admitted to the CECCS in Salamanca, Guanajuato, in which after months of caring for COVID-19 patients, new relevant laboratory studies were added (Ferritin and D-Dimer), therefore updates were made in statistical analyzes, and day-to-day behavior. The study is based on updating and cleaning the database, taking a sample of more patients with COVID-19, statistical analysis including admission tables, Body Mass Index, Variance, Normalization, relationship between the first day and the last day of patients who died and lived. The main idea of the work is to learn with more detail those laboratories that contain information to study in the future if there is a relationship between any medication supplied with the improvement or aggravation of the patient.
Parametric design applied to die cutting machine
Authors: Jara-Ruiz Ricardo , De La Cruz Jesús , Rodríguez-Franco Martín Eduardo , Delgado-Guerrero Sergio Humberto
Published: September 2021

In this paper, the particularities of applying parameterization in industrial machines corresponding to the manufacturing area are exposed and analyzed. For its development, the parameterized design of a die cutting machine is proposed as an object of study, which is formulated from the main elements considered of importance in the principle of operation, being necessary to carry out a prior investigation to analyze it and how the parameterization process influences. Parameterization is a quality of the components to adapt flexibly to the needs of the industry or sector, facilitating the redesign and manufacturing process, allowing the desired dimensional update or adjustment to be carried out only to the central component and the others are automatically adapted. Attending to the current needs and trends of the fourth industrial revolution, as well as establishing the benefits of this type of flexible design processes to expand their implementation to different industrial machines such as robot configurations.
Comparative study of P25/BiOCl mixtures as photocatalysts in Acid Orange 7 degradation
Authors: MENDEZ-ALVARADO Lorena , RIVERA-FLORES Miguel A. , SANDOVAL Miguel A. , FUENTES Rosalba
Published: September 2021

Objectives. Among strategies used to improve the photocatalytic properties of titanium dioxide (TiO2), coupled semiconductor has been widely studied. Bismuth oxychloride (BiOCl) semiconductor has been highlighted, specially, with hierarchical structures (3D), because it has been shown to have higher performance in the photodegradation of organic dyes in wastewater. Therefore, in this work the degradation efficiency of acid orange 7 (AO7) was studied using TiO2 (P25 Degussa), synthesized BiOCl with hierarchical structure, and mixtures of them as photocatalysts. Methodology. BiOCl was synthesized by the solvothermal method. The BiOCl was characterized by different techniques such as X-ray diffraction (XRD) and scanning electron microscopy (SEM). In addition, the pore distribution and the surface area were determined. Photocatalytic experiments were carried out with a photocatalyst dose of 1 g‧L-1, initial dye concentration of 50 mg‧L-1, and UV light illumination. Contribution. The interaction of P25 Degussa with BiOCl microspheres (75/25, respectively) improved the photocatalytic degradation achieving a 50% degradation efficiency.
Synergies: University-Museum Collaborations
Authors: Rende Kathryn , Teeter Stephanie Dawn , Owen Lewis
Published: September 2021

The purpose of this report is to provide documentation of the University-Museums Synergies Initiative between a Department of Marine, Earth, and Atmospheric Sciences and a Museum of Natural Sciences.The goals of this initiative were to 1)identify specific projects and opportunities might be developed to strengthen the collaboration between institutions and 2) gain a betterunderstanding of MEAS researchers’ and Museum employees' perspectives onuniversity-museum partnerships.
Statûya Zimên û Polîtîkayên Partîyan li Kurdistana Iraqê. Mînakên Guhertoyên Behdînî û Hewramî
Authors: SHEYHOLİSLAMİ Jaffer
Published: September 2021

Ev xebat statûya du guhertoyên zimanî yên Kurdistana Iraqê dide ber hev: Behdînî û Hewramî. Hikumeta Heremî ya Kurdistanê (HHK) herdu guhertoyan wekî guhertoyên Kurdî dibîne. Lê, herçiqas herdu guhertoyan ji bo perwerdeya bi zimanê zikmakî û naskirina resmî hewl dabin jî, tenê Behdînî karîye mafên zimên bi dest bixe. Ji bo lêkolîna sedemêm muhtemel yên newekhevîya statûya van herdu guhertoyan, vê xebatê polîtîkaya krîtîk ya zimên (critical language policy) û nêrîna dîrokî ya sazûmanî (historical construction approach) bi kar anîne. Vê gotarê ev herdu guherto ji çend alîyan ve dane ber hev: wekî zimannasî, pêvajoya pêşketina dîrokî, kevneşopîya nivîskî, têgihîştin û tevger, mobîlîzasyona etnozimanî, demografî û rewşa sosyo-ekonomîk, û wekî dawî sîyaset û hêza sîyasî ya civatan.
Addition to the studies of land molluscs of Armenia
Authors: Gural-Sverlova N. V. , Amiryan A. L. , Gural R. I.
Published: September 2021

In 2015-2016 land molluscs from 43 localities in Ararat Region, Vayots Dzor Region and Kotayk Region as well as in Yerevan were investigated. The introduced species Monacha fruticola and Oxychilus cf. filicum were first discovered on the territory of Armenia. One new locality of the rare species Orculella ruderalis , listed in the Red Book of Armenia, was found. Some pecularities of the intraspecific variability of the shells of O. ruderalis and Pseudochondrula tetrodon were described.
Development of a Double Row Tractor Operated Yam Minisett Planter
Authors:   Automotive and Refrigeration Engineering, Takoradi Technical University, Takoradi, Ghana., Arkoh A. K. , Bobobee E. Y. H. ,   Agricultural and Biosystems Engineering, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Addo A. ,   Agricultural and Biosystems Engineering, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Published: September 2021

Drudgery in manual yam minisett planting was identified as a major constraint facing yam cultivation in Ghana. The main objective of the study was to develop a double row yam minisett (DRYM) planter using Finite Element Analysis (FEA). A potato planter was adopted and modified to suit the design of DRYM planter. The main task was to perform 3D modeling of the planter major components using FEA method. Analysis of systems (ANSYS) software was used for FEA. Minisett and soil physical properties were factored into the design processes. Total deformation and equivalent (Von-Mises) stress were 0.442 mm and 7.37 MPa for hopper; 0.01 mm and 9.18 MPa for ridger bottom and that of furrow opener were 1.8-0.6 mm and 6.27 MPa, respectively. Maximum total deformation and equivalent (Von-Mises) stress were below material specification of 50 mm and 250 MPa for structural steel, and 20 mm and, 440 MPa for mild steel, respectively. The study concluded that the entire design was within the material property and permissible stress limits of the materials used. Yam planter development will enhance farmer satisfaction.
Digital Eco-system Development Proved its Sustainable Success under the Technology Covid-19 Disruption: Asia’s Silicon Valley Singapore Global ICT Power House South Korea
Authors:   Associate Professor- School of Communication Arts, Sukhothai Thammathirat Open University, Thailand., Intaratat Kamolrat
Published: September 2021

The study of “Digital Eco-system Development Proved Its Sustainable Success under the Technology & Covid-19 Disruption: Asia’s Silicon Valley (Singapore) & Global ICT Power House (South Korea) ” has its objectives under the context of COVID-19 pandemic and technology disruption as follow; 1)to study the scenario of digital eco-system development of Singapore and South Korea; 2) to study the government’s policy of Singapore and South Korea in its digital eco-system development; and 3) to propose the best Practices of digital eco-system development of Singapore and South Korea for further development in other countries. The qualitative research with document study and e-interview among 25 key informants from all of the relevant stakeholders: the policy, the private sector, and the marginal workers. Narrative description was used. Findings found Best Practices of digital eco-system development from both countries which aligned with most of the findings such as the Boston Consulting Group (2020) and others could be applied in other countries as follow; 1) The strong leadership and concrete and achievable vision from top management of both countries. Holistic, inclusive and sustainable development is the dominant flagship of both countries : The Skill Future of Singapore, and the Digital New Deal of South Korea; 2) The Partnership model with integrated strategy under the Win& Win Principle with clear innovation goals at all levels: “the Skills Future of Singapore” from Engineer Good Program to the last mile people in the Touch Community Services; and the 1) the Meister High schools 2) the Digital Upskill by each own company; 3) the Tax Credit, Tax Incentive measures; 4) the Training Levy Grant system; and 5) the SME Training Consortiums of South Korea. 3)The broad perspective and agile way of working. According to a study by Boston Consulting Group, effective 'Agile leadership' was found to have an impact on all the successful digital transformation projects. Leaders must manage change with a broader mindset and apply agile behavior broadly across the eco-system: Asia’s Silicon Valley” with its fully back up mission of “A Smart Nation”; and the “Korean New Deal” with its futuristic of digital eco-system as its national eco-system composed of its main Digital New Deal composed of the Green New Deal and the Human New Deal overarching social safety net, climate change and economic growth under the sustainable and inclusive development.