bluuebunny/crossref_metadata_2025 huggingface dataset:
Ejecta, Rings, and Dust in SN 1987A with JWST MIRI/MRS
Authors: Jones O. C. , Kavanagh P. J. , Barlow M. J. , Temim T. , Fransson C. , Larsson J. , Blommaert J. A. D. L. , Meixner M. , Lau R. M. , Sargent B. , Bouchet P. , Hjorth J. , Wright G. S. , Coulais A. , Fox O. D. , Gastaud R. , Glasse A. , Habel N. , Hirschauer A. S. , Jaspers J. , Krause O. , Lenkić L. , Nayak O. , Rest A. , Tikkanen T. , Wesson R. , Colina L. , van Dishoeck E. F. , Güdel M. , Henning Th. , Lagage P.-O. , Östlin G. , Ray T. P. , Vandenbussche B.
Published: November 2023

Supernova (SN) 1987A is the nearest supernova in ∼400 yr. Using the JWST MIRI Medium Resolution Spectrograph, we spatially resolved the ejecta, equatorial ring (ER), and outer rings in the mid-infrared 12,927 days (35.4 yr) after the explosion. The spectra are rich in line and dust continuum emission, both in the ejecta and the ring. The broad emission lines (280–380 km s−1 FWHM) that are seen from all singly-ionized species originate from the expanding ER, with properties consistent with dense post-shock cooling gas. Narrower emission lines (100–170 km s−1 FWHM) are seen from species originating from a more extended lower-density component whose high ionization may have been produced by shocks progressing through the ER or by the UV radiation pulse associated with the original supernova event. The asymmetric east–west dust emission in the ER has continued to fade, with constant temperature, signifying a reduction in dust mass. Small grains in the ER are preferentially destroyed, with larger grains from the progenitor surviving the transition from SN into SNR. The ER dust is fit with a single set of optical constants, eliminating the need for a secondary featureless hot dust component. We find several broad ejecta emission lines from [Ne ii], [Ar ii], [Fe ii], and [Ni ii]. With the exception of [Fe ii] 25.99 μm, these all originate from the ejecta close to the ring and are likely to be excited by X-rays from the interaction. The [Fe ii] 5.34 to 25.99 μm line ratio indicates a temperature of only a few hundred K in the inner core, which is consistent with being powered by 44 Ti decay.
CWISE J105512.11+544328.3: A Nearby Y Dwarf Spectroscopically Confirmed with Keck/NIRES
Authors: Robbins Grady , Meisner Aaron M. , Schneider Adam C. , Burgasser Adam J. , Kirkpatrick J. Davy , Gagné Jonathan , Hsu Chih-Chun , Moranta Leslie , Casewell Sarah , Marocco Federico , Gerasimov Roman , Faherty Jacqueline K. , Kuchner Marc J. , Caselden Dan , Cushing Michael C. , Alejandro Sherelyn ,   The Backyard Worlds: Planet 9 Collaboration,   The Backyard Worlds: Cool Neighbors Collaboration
Published: November 2023

Y dwarfs, the coolest known spectral class of brown dwarfs, overlap in mass and temperature with giant exoplanets, providing unique laboratories for studying low-temperature atmospheres. However, only a fraction of Y dwarf candidates have been spectroscopically confirmed. We present Keck/NIRES near-infrared spectroscopy of the nearby (d ≈ 6–8 pc) brown dwarf CWISE J105512.11+544328.3. Although its near-infrared spectrum aligns best with the Y0 standard in the J band, no standard matches well across the full YJHK wavelength range. The CWISE J105512.11+544328.3 NH3-H = 0.427 ± 0.0012 and CH4-J = 0.0385 ± 0.0007 absorption indices and absolute Spitzer [4.5] magnitude of 15.18 ± 0.22 are also indicative of an early-Y dwarf rather than a late-T dwarf. CWISE J105512.11+544328.3 additionally exhibits the bluest Spitzer [3.6]−[4.5] color among all spectroscopically confirmed Y dwarfs. Despite this anomalously blue Spitzer color given its low luminosity, CWISE J105512.11+544328.3 does not show other clear kinematic or spectral indications of low metallicity. Atmospheric model comparisons yield a log(g) ≤ 4.5 and T
eff ≈ 500 ± 150 K for this source. We classify CWISE J105512.11+544328.3 as a Y0 (pec) dwarf, adding to the remarkable diversity of the Y-type population. JWST spectroscopy would be crucial to understanding the origin of this Y dwarf’s unusual preference for low-gravity models and blue 3–5 μm color.
CAHA/PPAK Integral-field Spectroscopic Observations of M81. II. Testing Photoionization Models in a Spatially Resolved LINER
Authors: Li Zongnan , Li Zhiyuan , García-Benito Rubén , Jin Yifei
Published: November 2023

The origin of the low-ionization nuclear emission-line region (LINER) prevalent in local galaxies and its relationship with supermassive black holes have been debated for decades. We perform a comprehensive evaluation of traditional photoionization models against the circumnuclear ionized gas in M81, for which recent CAHA/PPAK integral-field spectroscopic observations reveal a LINER characteristic out to a galactocentric radius of ∼1 kpc. Constructed with the photoionization code cloudy, the models have the novel aspect of their primary parameters being well constrained by extensive observations of a prototypical low-luminosity active galactic nucleus (LLAGN) and an old stellar bulge in M81. Additionally, these models incorporate a reasonably broad range of uncertain nebular properties. It is found that the integrated photoionization by the LLAGN and hot, low-mass stars distributed in the bulge can roughly reproduce the observed radial intensity distributions of the Hα, Hβ, and [N ii] lines, with the bulge stars dominating the ionizing flux at radii ≳200 pc. However, the models generally fail to reproduce a similarly declining profile of the [O iii] line or an accordingly flat profile of the [O iii]/Hβ ratio. This clearly points to a deficiency of ionizing photons in the outer regions despite an extended photoionization source. The discrepancy might be alleviated if much of the observed [O iii] line arose from a bulge-filling, low-density gas surrounding a denser, Hα-emitting disk, or by a higher AGN luminosity in the recent past. The case of M81 has important implications for the ionization mechanism of LINERs and low-ionization emission-line regions in general.
Constraining the AGN Luminosity Function from JWST with the X-Ray Background
Authors: Padmanabhan Hamsa , Loeb Abraham
Published: November 2023

We predict the X-ray background (XRB) expected from the population of quasars detected by the James Webb Space Telescope spectroscopic surveys over the redshift range z ∼ 4–7. We find that the measured UV emissivities imply a ∼10 times higher unresolved XRB than constrained by current experiments. We illustrate the difficulty of simultaneously matching the faint end of the quasar luminosity function and the XRB constraints. We discuss possible origins and consequences of this discrepancy.
First record of the genus Camptotheca (Nyssaceae) in Vietnam and the lectotypification of C. acuminata
Authors: Zhu Zhen-Hua , Trinh Ngoc Bon , Hoang Thanh Son , Li Bo
Published: November 2023

As a primary source of anticancer camptothecin, Camptotheca (Nyssaceae) is an economically valuable genus and has long been recorded as endemic to China. Here, Camptotheca is reported as a new record to the flora of Vietnam with the discovery of a wild population of C. acuminata from Lai Chau Province of northern Vietnam. Based on the consultation of relevant literature and type specimens of C. acuminata, a lectotype of the species is designated. Photographic illustrations, morphological description and a distribution map of C. acuminata is provided, and a key to all known species of Nyssaceae in Vietnam is presented, too.
Comparison of seven complete mitochondrial genomes from Lamprologus and Neolamprologus (Chordata, Teleostei, Perciformes) and the phylogenetic implications for Cichlidae
Authors: Wang Jiachen , Tai Jingzhe , Zhang Wenwen , He Ke , Lan Hong , Liu Hongyi
Published: November 2023

In this study, mitochondrial genomes (mitogenomes) of seven cichlid species (Lamprologus kungweensis, L. meleagris, L. ornatipinnis, Neolamprologus brevis, N. caudopunctatus, N. leleupi, and N. similis) are characterized for the first time. The newly sequenced mitogenomes contained 37 typical genes [13 protein-coding genes (PCGs), two ribosomal RNA genes (rRNAs) and 22 transfer RNA genes (tRNAs)]. The mitogenomes were 16,562 ~ 16,587 bp in length with an A + T composition of 52.1~58.8%. The cichlid mitogenomes had a comparable nucleotide composition, A + T content was higher than the G + C content. The AT-skews of most mitogenomes were inconspicuously positive and the GC-skews were negative, indicating higher occurrences of C than G. Most PCGs started with the conventional start codon, ATN. There was no essential difference in the codon usage patterns of these seven species. Using Ka/Ks, we found the fastest-evolving gene were atp8. But the results of p-distance indicated that the fastest-evolving gene was nad6. Phylogenetic analysis revealed that L. meleagris did not cluster with Lamprologus species, but with species from the genus Neolamprologus. The novel information obtained about these mitogenomes will contribute to elucidating the complex relationships among cichlid species.
Going deeper and further: a range and depth extension for the deep-sea feather star Paratelecrinus cubensis (Carpenter, 1881) (Comatulida, Atelecrinidae), first record from the Western Pacific
Authors: Mei Zijie , Sha Zhongli , Sun Shao’e
Published: November 2023

A specimen belonging to the deep-sea feather-star family Atelecrinidae was collected in April 2018 at the Kocebu Guyot at 1294 m deep. Based on its morphological characters, the specimen was identified as Paratelecrinus cubensis (Carpenter, 1881). This species of feather star is restricted to the deep sea and was known only from 12 records from the Bahamas and Cuba at depths of 567–892 m. The data represent the first record from the Western Pacific Ocean and the deepest record known, extending the depth where this feather star has been found to beyond 1000 m. The morphological characteristics of the Kocebu Guyot specimen were essentially identical to the morphology of the neotype, with a slight difference in the dorsal spine at the end of the cirri. The phylogenetic analysis based on the mitochondrial cytochrome c oxidase subunit I (COI), 16S rRNA genes, 28S rRNA genes, and 18S rRNA genes reveal a close relationship of P. cubensis with P. wyvilli. Results of our molecular phylogenetic analysis are consistent with our morphological identifications. Our find extends the known geographical distribution of the feather star P. cubensis to the Western Pacific Ocean and provide insights into deep-sea biodiversity in the Kocebu Guyot.
Quelle science pour quel socialisme ? Pratiques et représentations de la science dans le socialisme européen
Authors: Prochasson Christophe
Published: November 2023

Les études ayant mis en évidence les liens qu’ont entretenus science et socialisme ne se comptent plus. On rouvre ici le dossier en mettant en avant trois configurations qui guidèrent cette rencontre. Sans réduire l’histoire des rapports entre science et socialisme à une succession d’étapes, chacune marquée par des formes différentes de lucidité scientifique, il est possible de distinguer trois paradigmes : le premier appartient à la sphère physico-mathématique, le deuxième est attaché aux sciences naturelles, le troisième se confond presque avec la sociologie.
Artistes au travail – Témoignages de comédiennes et comédiens professionnels
Authors: La direction du numéro
Published: November 2023

En octobre 2022 a lieu une rencontre à l’ESAT La Bulle Bleue de Montpellier entre les comédiennes et les comédiens M.-C. Alperine, M. Baiche, M. Blot, M. Brunie, A. Caillaud, T. Cantin, A. Chaigne, M. Colardeau, J. Colombo, L. Deleaz, G. Drouadaine, J.-P. Escalle, A. Esperito Santo, E. Folcher, F. Foulon, A. Frédéric, S. Frick, A. Gélis, S. Henocque, F. Hugot, C. Langlais, S. Lemaire, M. Le Pesquer, E. Le Tareau, L. Loviconi, A. Marin, D. N’Gaide, J.-N. Papera, M. Pelletier, K. Perez, L. Perrier, C. Podeur, P. Poli, J.-C. Pouliquen, S. Robic, S. Roussel, N. Sadji, M. Sicret, F. Spiry, R. Stéphane et R. Zmirou. Les artistes échangent autour de leur pratique artistique, sur ce qui les rassemble et les problèmes qu’ils rencontrent dans l’exercice de leur métier.
Pratiques artistiques et handicap. Les ESAT : des environnements capacitants, à quelles conditions ?
Authors: Combes-Joret Monique
Published: November 2023

A partir d’une étude de cas d’un des ESAT (Etablissement et services d’accompagnement par le travail) qui a formé et accompagné des travailleurs handicapés dans la professionnalisation dans le spectacle vivant, notre objectif dans cet article est d’éclairer la spécificité de ces activités artistiques, ici le théâtre, et de questionner leurs potentiels capacitants – capacité à développer les capabilités des personnes en situation de handicap accompagnées. Nous mettons en évidence les apports majeurs de ces pratiques ainsi que les tensions qu’elles peuvent générer. Cet exercice nous conduit à opérer une première différenciation entre la pratique de théâtre « professionnelle » (avec ses exigences spécifiques) et la pratique « amateure » s’appuyant sur le théâtre comme activité de soutien.
Exploration des interactions entre le TDAH, la régulation émotionnelle et les conduites addictives. Étude de deux jeunes adultes
Authors: Camus Charron Marjorie , Duriez Nathalie
Published: November 2023

Il existe un lien étroit entre le TDAH, la dysrégulation émotionnelle et les addictions. Les consommateurs de substances, TDAH et non-TDAH, perçoivent des effets positifs à la consommation sur leurs émotions et leur humeur. Le TDAH augmente le risque de développer des difficultés liées à l’usage de substances psychoactives, probablement du fait d’un mauvais contrôle des impulsions et des émotions et en vue d’une automédication des symptômes. À l’âge adulte, la persistance du TDAH est souvent associée à une prévalence plus élevée de polydépendance. Nous pensons que la prise en charge de ces patients, dès le plus jeune âge, sur le plan des symptômes du TDAH, dont la régulation émotionnelle semble être une composante, constitue un renforcement émotionnel et minore les symptômes du TDAH. L’incidence des troubles sur les proches des personnes touchées invite à impliquer l’entourage et les parents, sur un versant psychoéducatif et de soutien. Un traitement efficace de cette population comorbide nécessite une approche multimodale qui s’attaquera à la fois au TDAH et aux troubles émotionnels, ainsi qu’aux tendances addictives.
Les mesures de protection de l’enfant illicitement déplacé et le risque grave de danger : comparaison de l’office des juges américains et européens
Authors: Chalas Christelle
Published: November 2023

En application de la Convention de La Haye du 25 octobre 1980, il ne pèse pas d’obligation sur la juridiction américaine saisie d’une demande de retour de l’enfant illicitement déplacé d’examiner toutes les mesures de protection possibles lorsqu’elle envisage de refuser le retour sur le fondement d’un risque grave de danger auquel l’enfant serait exposé en cas de retour. La juridiction de refuge a la faculté (« discretion ») de refuser le retour d’un enfant en cas de risque grave de danger et rien dans la convention ne lui impose, ni ne lui interdit, de prendre en considération les mesures de protection susceptibles de parer au danger ou de l’atténuer. En imposant une telle obligation aux juridictions saisies d’une demande de retour, la juridiction d’appel a indûment accordé un poids excessif à l’objectif de retour de l’enfant enlevé alors que la convention de La Haye de 1980 poursuit d’autres objectifs, dont celui de protéger l’enfant.
Pour une approche décoloniale du droit international privé
Authors: Brachotte Sandrine
Published: November 2023

Le présent article présente l’approche décoloniale du droit international privé qui a fait récemment son entrée dans la liste des sujets pressants pour la discipline, non seulement dans les pays colonisés mais aussi en Europe. En France, le sujet n’est peut-être pas encore abordé comme tel, mais est au moins apparu dans une thèse défendue à l’école de droit de Sciences Po Paris en mai 2022, intitulée « The Conflict of Laws and Non-secular Worldviews: A Proposal for Inclusion » (Le droit international privé et les visions du monde non laïques : une proposition d’inclusion). Cette thèse préconise notamment de revisiter le principe de l’autonomie de la volonté, la reconnaissance, et la compétence internationale pour les rendre plus perméables des visions du monde non occidentales. Après avoir proposé une description de la pensée décoloniale et du courant de décolonisation du droit international privé, cette contribution résume les points essentiels de la thèse à cet égard, et identifie les questions plus larges qu’elles posent au droit international privé, spécialement quant aux notions de « droit », d’« étranger », et de « conflit ».
Les conflits de juridictions à l’épreuve de l’individualisme
Authors: Lenglart Elie
Published: November 2023

Le constat est généralement partagé qui fait de l’individualisme l’un des traits spécifiques de notre modernité juridique. Reposant sur une conception du monde particulière conférant à l’individu une primauté irréductible dans la description et de l’évaluation du réel, la doctrine individualiste emporte d’importantes conséquences dans l’ensemble des branches du droit, et le droit international privé n’y fait évidemment pas exception. Si son influence en matière de conflit de lois semble aisément perceptible, l’incidence de cette tendance dans le domaine des conflits de juridictions ne doit pas être sous-estimer. Celle-ci se laisse en effet déjà percevoir sur le terrain de la détermination de la compétence internationale des juridictions françaises, cela par la mise à disposition de l’individu des divers fors disponibles ainsi que par la tendance à l’extension du choix volontaire de for donnant aux intérêts individuels. Elle se fait également ressentir au stade de la circulation des décisions étrangères en imposant de garantir la reconnaissance des statuts individuels aux conditions les plus libérales qui soient, traduisant ainsi la réorganisation de l’ensemble du système autour de l’individu.
Les trois couronnes d’Henri III : note de lecture sur l’œuvre du professeur Ordine
Authors: López-López Raúl
Published: November 2023

Nuccio Ordine son œuvre Trois couronnes pour un roi. La compagnie d’Enrique III et ses mystères , décrypte les significations de la compagnie d’Henri III et reconstitue le panorama culturel et historique d’une époque à travers sa littérature, ses images, sa numismatique, son héraldique, ses ballets, ses marques typographiques, ses compagnies et ses emblèmes. L’ouvrage du professeur Ordine révèle le sens de l’entreprise du roi Henri III à la lumière des dialogues italiens de Giordano Bruno et montre l’importance qu’elle eut pour le philosophe Balet Comique de la Royne et ses séjours en France et en Angleterre.
Identification and validation of aging-related genes and their classification models based on myelodysplastic syndromes
Authors: Gu Xiao-Li , Yu Li , Du Yu , Yang Xiu-Peng , Xu Yong-Gang
Published: November 2023

Background

Myelodysplastic syndrome is a malignant clonal disorder of hematopoietic stem cells (HSC) with both myelodysplastic problems and hematopoietic disorders. The greatest risk factor for the development of MDS is advanced age, and aging causes dysregulation and decreased function of the immune and hematopoietic systems. However, the mechanisms by which this occurs remain to be explored. Therefore, we explore the association between MDS and aging genes through a classification model and use bioinformatics analysis tools to explore the relationship between MDS aging subtypes and the immune microenvironment.

Methods

The dataset of MDS in the paper was obtained from the GEO database, and aging-related genes were taken from HAGR. Specific genes were screened by three machine learning algorithms. Then, artificial neural network (ANN) models and Nomogram models were developed to validate the effectiveness of the methods. Finally, aging subtypes were established, and the correlation between MDS and the immune microenvironment was analyzed using bioinformatics analysis tools. Weighted correlation network analysis (WGCNA) and single cell analysis were also added to validate the consistency of the result analysis.

Results

Seven core genes associated with ARG were screened by differential analysis, enrichment analysis and machine learning algorithms for accurate diagnosis of MDS. Subsequently, two subtypes of senescent expressions were identified based on ARG, illustrating that different subtypes have different biological and immune functions. The cell clustering results obtained from manual annotation were validated using single cell analysis, and the expression of 7 pivotal genes in MDS was verified by flow cytometry and RT-PCR.

Discussion

The findings demonstrate a key role of senescence in the immunological milieu of MDS, giving new insights into MDS pathogenesis and potential treatments. The findings also show that aging plays an important function in the immunological microenvironment of MDS, giving new insights into the pathogenesis of MDS and possible immunotherapy.
Machine learning-based approach for efficient prediction of diagnosis, prognosis and lymph node metastasis of papillary thyroid carcinoma using adhesion signature selection
Authors: Sun Shuo , Cai Xiaoni , Shao Jinhai , Zhang Guimei , Liu Shan , Wang Hongsheng
Published: November 2023

The association between adhesion function and papillary thyroid carcinoma (PTC) is increasingly recognized; however, the precise role of adhesion function in the pathogenesis and prognosis of PTC remains unclear. In this study, we employed the robust rank aggregation algorithm to identify 64 stable adhesion-related differentially expressed genes (ARDGs). Subsequently, using univariate Cox regression analysis, we identified 16 prognostic ARDGs. To construct PTC survival risk scoring models, we employed Lasso Cox and multivariate + stepwise Cox regression methods. Comparative analysis of these models revealed that the Lasso Cox regression model (LPSRSM) displayed superior performance. Further analyses identified age and LPSRSM as independent prognostic factors for PTC. Notably, patients classified as low-risk by LPSRSM exhibited significantly better prognosis, as demonstrated by Kaplan-Meier survival analyses. Additionally, we investigated the potential impact of adhesion feature on energy metabolism and inflammatory responses. Furthermore, leveraging the CMAP database, we screened 10 drugs that may improve prognosis. Finally, using Lasso regression analysis, we identified four genes for a diagnostic model of lymph node metastasis and three genes for a diagnostic model of tumor. These gene models hold promise for prognosis and disease diagnosis in PTC.
Detect Lane Line for Self-Driving Car Using Hue Saturation Lightness and Hue Saturation Value Color Transformation
Authors: Kadhim Hussam Jaafar , Abbas Amal Hussein
Published: November 2023

Self-driving vehicles require the ability to perceive and understand their surroundings, just like human drivers. It entails navigating efficiently on roads, obeying traffic signs and signals, and avoiding collisions with other vehicles and pedestrians. To address the challenges associated with object detection in self-driving cars, an effort was made to demonstrate lane detection using the OpenCV library. To achieve this goal, the well-established probabilistic Hough transform technique is used for line detection. Before applying Hough transforms, several pre-processing techniques are used, including converting the image to grayscale, camera calibration, and implementing a masking filter. In addition, edge detection is performed using the edge detection method. The study also indicates a preference for the use of HSL (Hue, Saturation, and Lightness) and HSV (Hue, Saturation, Value) color spaces. When HSL is applied, white lines appear purer and brighter, resulting in superior performance compared to using HSV specifically to detect white. This algorithm proved particularly effective in detecting straight lanes, which achieved an accuracy ratio of 96.06%. By incorporating these methodologies, the lane detection algorithm implemented with the OpenCV library addresses the challenges of self-driving vehicles, providing them with improved perception capabilities similar to human drivers.
Design and Development of Sign Language Learning Application for Special Needs Students Based on Android Using Flutter
Authors: Dony Novaliendry  , M. Fadilah Putra Pratama  , Khairi Budayawan  , Yasdinul Huda  , Wan Mohd Yusof Rahiman
Published: November 2023

Sign language is a communication system used by individuals with hearing impairments to interact and convey messages without using verbal sounds. Sign language has its own unique grammatical structure and vocabulary, enabling sign language users to express ideas and emotions through facial expressions, hand movements, and body positions. In this research, we explore important aspects of sign language, including its uniqueness, complexity, and diversity across different countries and cultures. We also discuss the role of sign language in facilitating communication, education, and social inclusion for the deaf community. This research highlights the significance of introducing and developing sign language competence among the general public, educators, and professionals in the fields of healthcare and social services. The development of the sign language learning media utilizes the Multimedia Development Life Cycle method. The main application used in creating the sign language learning media is Flutter, along with supporting applications such as Adobe Illustrator 2020 and Adobe Photoshop CC 2019. The features included in this application are finger alphabet signs, number signs, video tutorials for numbers and letter signs, quizzes, and learning objectives.
A Qualitative Exploration of Students' Perception of Care When Learning Online
Authors: Al-Freih Maha , Robinson Heather
Published: November 2023

The dramatic shift to remote learning due to the COVID-19 pandemic has highlighted certain global challenges associated with online learning, including our need to better understand the nature of caring relationships in online learning. In the present study, Noddings's care-centered model of education was applied to explore students' perception of care and caring behaviors in online courses and the design and pedagogical practices associated with a sense of being cared for based on interviews with 14 online learners. Findings from this study support the notion that online learning environments are robust enough to allow for caring relations to emerge. However, the analysis of student data pointed to a possible missing element in Noddings's model when applied to online learning, namely “anticipating.” Further, the study highlighted the critical role played by instructors' competencies in designing collaborative learning activities and feedback processes in the enactment of care ethics when teaching online. A discussion of findings and their implications for online teaching is provided.
Dynamic 3D culture promotes lymphoid tissue maturation and allows the study of Chronic Lymphocyitc Leukemia cells dissemination in vitro
Authors: Barozzi D. , Scagnoli F. , Mantegazza F. , Barbaglio F. , Ribezzi D. , Farè S. , Vergani B. , Berno V. , Ghia P. , Scielzo C.
Published: November 2023

Not available.
Design and fabrication of an intestinal phantom
Authors: Signorello P. , Cacopardo L. , Guazzelli N. , Nicolai I. , Ahluwalia A.
Published: November 2023

Not available.
Global 3R approach and bioreactors in biomedical research
Authors: Calvillo L.
Published: November 2023

Not available.
GENESIS-Guidance, Education, Networking, and Empowerment-based Smart Initiative for Students research in health care: A research modeling experience from a newly established medical college
Authors: Nathani Priyansh , Goyal Shreya , Junnarkar Yash , Prajapati Khushi
Published: November 2023

The importance of undergraduate medical research has been undermined in Indian medical education. Various studies show there is a drastic difference between the research output of Indian medical graduates in comparison to Western counterparts. With all the challenges identified, a student-oriented research committee was formed –Guidance, Education, Networking, and Empowerment-based Smart Initiative for Students (GENESIS) research in health care – A research modeling experience from a newly established medical college. The structure was established to serve the needs of students in the field of research. Problems were identified with the help of a survey, and steps were taken to address the issues through its 4-pronged strategy that includes conducting regular journal clubs. Journal clubs follow a peer-to-peer learning strategy and provide an open stage for discussion. Second, a research tracker which helps in increasing the sustainability of a research project. The third strategy includes a research live matchmaker which helps in bridging the gap between the students and the faculties. Lastly, involving alumni in the initiative will help students get guidance and acts as a gateway to opportunities at the national level. For maintaining the integrity and sustainability of the initiative, the involvement of students from all the batches is made sure. Inputs from faculties and administration are taken on a regular basis. Interinstitutional collaborations and regular assessment and evaluation are done to ensure positive outcomes. With its focus on peer-to-peer mentoring and attempt to eliminate the barriers for research enthusiasts, GENESIS has the potential to make a lasting impact in promoting research culture in colleges.
Linear fractional self-maps of the unit ball
Authors: Pilla Michael R.
Published: November 2023

Determining the range of complex maps plays a fundamental role in the study of several complex variables and operator theory. In particular, one is often interested in determining when a given holomorphic function is a self-map of the unit ball. In this paper, we discuss a class of maps in
$\mathbb {C}^N$
that generalize linear fractional maps. We then proceed to determine precisely when such a map is a self-map of the unit ball. In particular, we take a novel approach, obtaining numerous new results about this class of maps along the way.
The Sullivan dictionary and Bowen–Series maps
Authors: Mj Mahan , Mukherjee Sabyasachi
Published: November 2023

The Sullivan dictionary between Kleinian groups and rational dynamics describes striking similarities between the fields, both in terms of the objects of study as well as the techniques used. We give an expository account of a recent bridge between the two sides of the dictionary by describing a framework for combining a Fuchsian group with a complex polynomial into a single dynamical system on the Riemann sphere.
The Challenges in Conducting Economic Evaluations for Rehabilitation Technologies
Authors: Chan Brian Chun-Fai
Published: November 2023

Background

Health technology assessment (HTA) is an important evidentiary component in the decision-making process for the adoption of new healthcare technologies to the healthcare system. Economic evidence is an important consideration in HTAs. Recent systematic reviews in rehabilitation have shown a limited number of economic evaluations and high levels of uncertainty in the results. It is unclear whether there are challenges related to the field of rehabilitation and the technologies used in rehabilitation that inhibit the development of economic evidence.

Methods

In this study, economic evaluations in rehabilitation were reviewed. This was followed by a summary of the latest evidence on the challenges of conducting HTA for medical devices and the relationship with rehabilitation technologies. Finally, several considerations are suggested to improve the HTA of technologies that target rehabilitation. A literature review of Google Scholar and PubMed was conducted to identify reviews in economic evaluations in rehabilitation. A recent review on the barriers to HTA of medical devices in general was also examined to identify similar concerns with rehabilitation technologies.

Results

The challenges identified include the lack of high-quality studies, the interaction between the technology and the user, the short product life cycle, and estimation of efficacy in technologies with multiple target populations.

Conclusion

Overall, many of the challenges in evaluating medical devices also apply to rehabilitation interventions. Further research and discussion on these issues are necessary to increase the clinical evidence for rehabilitation technologies, strengthen the development of HTAs, and facilitate the use of technologies to improve the health of individuals requiring rehabilitation.
PREPARATION AND EXPERIMENTAL STUDY (IN VITRO) OF PURANDAR VATI
Authors: A. Tupe Kadambari , Deshmukh Ashvini Y.
Published: November 2023

Objective To prepare and evaluate the antimicrobial effect of Purandar vati (An Ayurvedic traditional formulation )against some of the bacterial stains. Method, Purandar vati was prepared using the classical reference of
Bhaishajyaratnavali. Parada (Mercury) and Gandhaara (sulphur) were purified and then triturated to form Kajjali. Then raw drugs of Triphala and trikatu were converted into powder form, and all the ingredients were mixed
and triturated with the help of aja dughdha (goat milk) and tablets were formed. The final product of Purandara
vati was dried and stored. Antimicrobial activity of Purandar vati against streptococcus pneumonia and morxella
catarrahlis bacteria was evaluated using the agar cup diffusion method. Result: Purandar vati shows a significant
antibacterial spectrum against streptococcus pneumonia and morxella catarrahlis. Conclusion: This study shows
that Purandara vati has antimicrobial potency and it can be clinically used for infectious respiratory disorders.
GODHOOM & YAVA PINDA CHIKITSHA IN PRASRAMSINI YONI VYAPD (SECOND DEGREE UTERINE PROLAPSE WITH CYSTORECTOCELE)
Authors: Kumari Nisha , Kapil Soni , Bhardwaj Anil
Published: November 2023

In modern era due to altered lifestyle and working motherhood, the rest needed for women during menstruation & during puerperal period is not available. Acharyas have been mentioned the importance of Rajahswalacharya and Sutika Paricharya in our classics. Protrusion of the pelvic organs into or out of the vaginal canal is known as Pelvic Organ Prolapse. It results from weakening or damage to pelvic supporting structures that maintain pel-vic organs' position in-situ. The problem unmasks after delivery and with age progression, due to injury/ laxity of pelvic supporting structures. Anything that increases intra-abdominal pressure can lead to pelvic organ prolapse e.g., chronic constipation, heavy weightlifting& strenuous exercises. Acharya Sushruta has mentioned that Prasramsini Yonivyapda occurs due to chronic irritation & difficult labor. Clinical features of Prasramsini Yonivyapda are Pitta and Vata dominant. According to WHO estimation the global prevalence of uterine pro-lapse is 2-20%. A non-surgical approach to relieve the symptoms is need of hour as surgical management is not a good option for a female of reproductive age group. Moreover, recto cystocele corrected by colpoperineorraphy sometimes doesn’t provide sustainable results. A female patient aged 42 years came to PTSR OPD with com-plaints of something coming out of her vagina for 6 months, heaviness and pain in lower back for 6 months. SthanikChikitsa (Local treatment) was advocated to her for three consecutive cycles after clearance of menses. Yoni Purana was done with medicated Yava, Godhuma Pind (by inserting in vagina) after local Snehan and Sve-dana. Pre and post POP-Q scale were used to assess the results. Patients got relief in her symptoms through this Ayurvedic approach.
A CLINICAL STUDY ON ‘RASNADI PANCHDASHAKAM KWATHA’ IN THE MANAGEMENT OF AMAVATA (RHEUMATOID ARTHRITIS)
Authors: Kumawat Megha , Kumar Mishra Pramod , Sharma Brahmanand
Published: November 2023

The disease Amavata can concern the result of a combination of Ama and Vata due to Mandagni. According to the
clinical features, Amavata very closely resembles the Rheumatoid Arthritis. According to modern science,
Amavata considered an autoimmune condition known as Rheumatoid Arthritis (RA), results in chronic joint inflammation. The prevalence of RA is 0.8% globally. According to a survey of community prevalence, women
experience the condition at a 3:1 ratio to men. Without regard of sex, religion and other factors like occupation, a
total of 40 individuals with the defining signs and symptoms of Amavata were chosen for this research trial. In the
present clinical practice, Rasnadipanchdashakam Kwatha was given orally, 20 ml twice a day for 45 days. Results
revealed statistically substantial reductions in Sandhishoola 61.76%, Sandhishotha 42.16%, and Sandhijadyata
49.41%. Additionally, results for Angmarda 52.11%, Aruchi 51.38%, Trishna 51.61%, Alasya 63.01%, Gaurava
50%, Jwara 58.92%, Apaka 59.42%. The overall results of the study were 53.97%.
A COMPARATIVE PHARMACEUTICO-ANALYTICAL STUDY OF DHANANJAYADI
VATI AND ITS MODIFIED LOZENGES
Authors: Mudukannanavara Srikantha , s pai Nayana , fernades Rohan
Published: November 2023

Vati Kalpana is one of the secondary preparations in Ayurvedic pharmaceutics. According to acharya Vagbhata,
it is considered as an outcome of Kalka Kalpana1
. Dhananjayadi Vati is a formulation mentioned in
Yogaratnakara under Kasa Chikitsa. Modification of classical and development of new dosage forms is currentday trend to fulfil needs like palatability, cost effectiveness and global acceptance of the product. Lozenges are
one of the popular palatable solid dosage forms containing one or more medicaments in a flavored and sweetened
base. In the present study an attempt was made to modify Vati into lozenges form and comparative pharmaceutico
analytical study was carried out for understanding of each dosage was discussed.
A CLINICAL STUDY TO EVALUATE THE EFFECT OF SET OF PRANAYAMA AND
BREATHING EXERCISES IN POST COVID-19 PATIENTS
Authors: S Kamatar Vijayalaxmi , Dhanya B.S Srinidhi , Kumar Shetty Sandesh
Published: November 2023

Although there had been enormous development in the field of medical science presently, the importance of ancient methods of preventing diseases could not be ignored even in 21st century. Communicable diseases continue
to be a major public health problem in India. The root-cause of Janapadodhwansha is Adharma which in this context means non-performance of one’s duties with honesty or as per rules of the nature or country. Adharma arises
due to Pragnaparadha (intellectual errors occurring knowingly). Janapadodhwansha can be prevented and controlled by using Panchakarma i.e., purification procedures like vamana (emesis), virechana (purgation), vasti
(medicated enema) and nasya (using medicines through nasal route), rasayana and obeying the sadavritta (code of
conduct). COVID-19 is a great nightmare to mankind. Recent studies suggest that 75.4% patients had abnormal
pulmonary function tests even after the discharge from hospital. These changes may also affect the quality of life
of the individuals. Improving the lung capacity may help in normalizing the pulmonary functions.
In this regard pranayama and deep breathing techniques plays a great role to restore lung capacity in COVID-19
recovery process. Pranayama improves overall performance of the body.
A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF JEERAKAWLEHA AND YASTIMADHU CHOORNA IN THE MANAGEMENT OF ASRUGDARA
Authors: Sawale Dipali , Jawale Veena
Published: November 2023

Women is endowed with energy of procreation for which menarche is the first step. Menstrual cycle commences
with this and ends with menopause and having normal menstruation depicts the wellbeing of female. In normal
menstruation the duration of menstruation is about 4-5 days, and the amount of blood loss is estimated to be 20-
80ml with an average 35 ml. Due to pradirana(excessive excretion) of raja (menstrual blood), it is named as pradara/asrugdara. Asrugdara characterized by excessive prolonged menstrual or intermenstrual bleeding due to
Pradirana (excessive excretion) of raja (Menstrual blood), it is named as Pradara and or Asrugdara. As heavy
menstrual bleeding is a debilitating disorder, the woman requires rapid, safe and effective treatment. In ayurvedic
classicc a variety of treatments in the management of asrugdarahas been described. Out of them, the subject is
selected to compare efficacy of Jeerakavaleha mentioned by Yogratnakara, with effect of Yastimadhu choornamentioned by Bhavaprakasha which is already proved in the previous study. Jeerakavaleha has Gerbhashyashodhaka, stambhaka, raktapittahara property.
REVIEW ARTICLE ON VISHGHANA PROPERTY OF MANJISTHA
Authors: sharma Kritica , Kapoor Ritu , Adlakha Manoj
Published: November 2023

Poisoning being the major health problem in modern era which is increasing day by day. There are different
sources from where people are consuming poison directly or indirectly. According to Ayurvedic point of view,
there are different types of poison like Sthavar Visha, Jangam Visha, Gara Visha, Dushi Visha. So, after taking
such poison shows harmful effect in human health which leads different kinds of diseases to death. So, to protect
from such kinds of poisoning Ayurveda has mentioned different types of detoxifying Dravyas that help to diminish or destroy the poisonous effect in human body. The Concept of Ayurvedic Vishaghna mahakashaya explained
by Acharya Charaka has the properties of detoxifying action. As per Ayurved classics, it is included in the
Vishaghna gana (Anti poisonous drugs) and is an important constituent of several Agada (Anti-poisonous formulations). Agada, one of the modalities used for treatment of poisoning is a combination of different herbs. Manjistha, as a single and multiple preparations are available which indicates its utility in many poisonings. Manjistha
is not only used as Vishaghna (anti poisonous) drug, but it has multiple therapeutic values, which are discussed in
the article. Selection of all logical references are done and collection, correlation and explanation as per requirement. It can be useful for diseases which come under area of any field of toxicity. Hence, we can prevent and treat
many toxicological disorders.
GENETICS IN AYURVEDA W.S.R. TO DEVELOPMENTAL ANATOMICAL DEFORMITIES AND THEIR PREVENTION -A REVIEW
Authors: Sharma Khushboo , lakhiwal Pooja , Sharma Mahendra
Published: November 2023

Medical science hasn't been able to reduce the prevalence of congenital malformations despite improvements in
diagnostic methods and therapeutic approaches. This is something that the traditional Indian medical system of
Ayurveda has placed a lot of emphasis on and has proposed a number of countermeasures. In Ayurveda, Sahaja
Roga, Kulaja Roga, Adibala Pravritta Roga, and Janmabala Pravritta Roga all go into great detail about the idea
of congenital diseases. It has been made clear what the prenatal causes, safeguards, and disease categories are. In
Ayurvedic texts, the significance of the Shad-Garbhakara Bhavas (six pro-creative factors), including Matrija
(maternal), Pitrija (paternal), Atmaja (soul), Rasaja (nutritional), Satmyaja (wholesomeness), and Sattvaja (psyche/mind), is discussed. It is thought that for healthy progeny, these pro-creative factors must come together. In
order to raise healthy children, it is important to consider one's own physical, mental, social, and spiritual wellbeing as well as the mother's diet during pregnancy and one's own adherence to a wholesome routine.
ROLE OF SWASTHVRITTA IN SPORTS MEDICINE
Authors: Kumari Dhaker Santara , Kumar Mishra Pramod , Sharma Brahmanand , Rajpurohit Hemant , Rangani Nupur
Published: November 2023

Ayurveda is an ancient Indian medical system. Sports medicine is a discipline of medicine that deals with physical fitness as well as the treatment and prevention of sports and exercise-related injuries. Direct references of this
neither mentioned in ancient nor in modern medicine. Sportsmen's basic needs are to maintain fitness throughout
events and to have increased physical and mental stamina. Sports medicine has two objectives. The primary goal
is to improve the athlete's fitness, and the secondary goal is to treat the athlete's athletic injuries. So, without a
doubt, prevention is better than treatment in the case of athletes. When it comes to prevention, Ayurveda may play
a major role, as the first goal of Ayurveda is "Prevention of Health." Ayurveda is one of the world’s oldest holistic
healing systems, which is based on the thought that health and wellness depend on a fine equilibrium between the
mind, body and spirit. Ayurveda can make some possible contributions to this field of sports medicine. We certainly do not find direct references to sports medicine in Ayurvedic samhitas, but after much close observation
and precise interpretation of Ayurvedic texts, we discovered an idea about how to deal with sports medicine.
Vyayama (exercise), Abhyanga (massage), Yoga Asanas, Dhyana (meditation), Rasayana (Rejuvenation therapy),
Dincharya (Daily regimen) and other Ayurvedic procedures can provide the best results in sports medicine.
AN OBSERVATIONAL STUDY TO ASSESS THE MANASIKA BHAVA W.S.R. TO
GURUVYADHITA AND LAGHUVYADHITA – A REVIEW ARTICLE
Authors: Santhoshini R , G. Bhat Vijayendra , Kamath T Shrilatha
Published: November 2023

Understanding Mental Health plays a major role in a clinical setup which enables a clinician in arriving at proper
diagnosis, planning suitable treatment, assessing the mental status of the patient during the treatment to decide the
rate of recovery and analyze the true prognosis of the condition. The capacity to withstand adversity in life is different for each individual based on the kind of Sattva developed during pregnancy or nurtured during the lifetime.
Sattva can be most accurately measured when an individual experiences a threat to life, as based on the Sattva
Bala the road to recovery or perish gets decided. Therefore, to enhance the overall success rate of any intervention, an initial understanding of these individuals through Manasika Bhava assessment is essential. People categorised as Guruvyadhita showed more positive Manasika Bhava when compared to people categorised as
Laghuvyadhita. Similarly, people categorised as Laghuvyadhita showed more of negative Manasika Bhava than
the people categorised as Guruvyadhita. Better Sattva Guna is indicative of exhibiting better coping skills. A vital
part of diagnosis, treatment, and understanding the prognosis of the patient is played by Sattva assessment and
must be carried out as a routine protocol in a clinical set up.
APPLIED ASPECT OF SATVAVAJAYA CHIKITSA
Authors: Singh Rita , Singjh C. B. , Kumar Yogesh , Kumar Ajay , Singh Shailendra
Published: November 2023

The human being is a tripod having three pillars, Satva (mind), Atma (soul) and Sharira (body). Here, Satva is a connecting link between Atma and Sharira, which is otherwise called Manas. It has an immense influence on the health and ill health of the individual. ‘Prasanna’ Manah is a sign of a healthy life.
In Ayurvedic contexts, Chikitsa is classified into two parts based on resources (Vyapashraya Bheden): 1. Daivvyapashray Chikitsa 2. Yuktivyapashray Chikitsa. Daivvyapashray Chikitsa refers to Mantra, Ausadhi, Mani, Mangala, Bali, Upahara, Home, Niyam, Prayashchita, Upvasa, Swastyayanapatha, Pranipata, Gamana etc. Yuktivyapashrya Chikitsa refers to Samsodhana (Vamanadi) and Upshamana (Pachanadi). In another context, Acharya Charak and Acharya Vagbhat explained Trividham Ausdham as; 1. Daivvyapashray Chikitsa, 2. Yuktivyapashrya Chikitsa 3. Satvavajaya Chikitsa. Their Satvavajaya Chikitsa further explained, "Aiming to control the mind or is a method of restraining the mind from unwholesome objects.” Satvavajaya Chikitsa is that typical Ayurvedic approach that prevents the impaired Dhi, Dhriti and Smriti and brings them back to a normal state. Hence, it plays a significant role in maintaining a harmonious state between these three factors, ultimately leading to a happy and healthy state of the individual.