bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of atmospheric refraction on detecting elevated sources with beamforming algorithms
Authors: Goldman Geoffrey H.
Published: September 2022

Classical beamforming algorithms are based on rectilinear propagation of signals that are corrupted by additive noise. However, sound waves propagating in the atmosphere are refracted by temperature and wind gradients and distorted by turbulence and scattering from the ground. These effects can reduce the performance of acoustic systems. To investigate these effects, a simulation capability is used to propagate signals from elevated sources to an array of microphones near the ground. Detection algorithms based on four standard beamforming algorithms, implemented with either no model mismatch error or model mismatch errors generated by atmospheric refraction, are tested. The results are evaluated using the area under the receiver operating characteristic curve statistic. The analysis shows no significant improvement in detection performance when refraction effects are included in the beamforming algorithms over a wide range of frequencies. Any small performance improvements achieved by incorporating refraction effects into the beamforming algorithms are overwhelmed by the negative effects of atmospheric turbulence and rough surface scattering. For the selected scenario, incorporating refraction effects into the beamformers is over-engineering. These results demonstrate some of the limitations of developing new signal processing algorithms or array designs for atmospheric acoustic systems.
Balancing neuronal circuits
Authors: Blumenstock Sonja , Dudanova Irina
Published: September 2022

Correcting synaptic defects in development delays Huntington’s disease symptoms in older mice
In Other Journals
Authors: Scanlon Seth Thomas , Nusinovich Yevgeniya , Jiang Di , Lopez Bianca , Smith H. Jesse , Lavine Marc S. , Stajic Jelena
Published: September 2022

Editors’ selections from the current scientific literature
Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret Model
Authors: Pulit-Penaloza Joanna A. , Belser Jessica A. , Sun Xiangjie , Pappas Claudia , Brock Nicole , Kieran Troy J. , Ritter Jana M. , Seixas Josilene N. , Jones Joyce , Basu Thakur Poulami , Pusch Elizabeth , Wang Li , Tumpey Terrence M. , Wentworth David E. , Zhou Bin , Maines Taronna R.
Published: September 2022

Continued surveillance and risk assessment of emerging SARS-CoV-2 variants are critical for pandemic response and preparedness. As such,
in vivo
evaluations are indispensable for early detection of variants with enhanced virulence and transmission.
Supplemental Material: Climatic influence on the expression of strike-slip faulting
Authors: Reitman Nadine G. , al. et
Published: September 2022

Supplemental methods, figures, and tables, as well as plots of each data set showing the b value calculation 
Supplemental Material: Resetting of zircon inclusions in garnet: Implications for elastic thermobarometry
Authors: Campomenosi Nicola , al. et
Published: September 2022

 Additional data and analytical details. 
The Factor of Australia in British Foreign Policy
Authors: Godovanyuk K. A.
Published: September 2022

The Australian component of UK foreign policy in the context of the changing world order is outlined. It is highlighted that, in a value and ideological sense and due to the common Anglo-Saxon identity, London assigns Canberra a key role in the coalition of like-minded countries (“network of liberty”); in geostrategic terms, it perceives Australia as a platform to expand the UK influence in the Indo-Pacific. At present, the “special” partnership between the two countries is underpinned by a number of new agreements, including a “historical” trade deal aimed at strengthening economic ties and in-depth political, diplomatic, and defense cooperation, based on a new military alliance, AUKUS. At the same time, the traditional pragmatism inherent in the foreign policy of Australia, which positions itself as a reliable international actor, is being replaced by increasing military–political and economic dependence, which plays into the hands of London. Coming closer with Australia also allows Britain to present itself as the key extraregional player in the system of anti-Chinese alliances in the Indo-Pacific, with Washington and Canberra in the forefront.
European Culture: Centripetal and Centrifugal Forces
Authors: Gromyko Al. A.
Published: September 2022

The main features of the transformation of European culture in the modern world are explored. Chronologically, this study is based on the idea of the general humanistic foundations of European culture since the 1980s. The author describes its state during the Cold War, and then analyzes the search for its new meanings, including the concept of the “new Middle Ages” and the theme of fear. Another dimension of the research is the role of the Age of Enlightenment in the history of European culture and its later development in the context of liberalism, consumerism, and individualism. Contemporary European culture is characterized as an overlap of premodern, modern, and postmodern. The problem of Westernization and standardization of culture is dwelt upon together with the shift to different currents of postmaterialism and neo-avant-garde art.
The Influence of NATO Regional Missile Defense on European Security
Authors: Krivolapov O. O.
Published: September 2022

The problem of missile defense is considered by Russian researchers, first of all, as part of the strategic stability problem in relations between Russia and the United States. At the same time, the impact of regional missile defense (theater missile defense) on regional security remains largely unexplored. The US and NATO leadership continue to claim that Russia has deployed intermediate-range missiles in the European part of the country. As a response to this step, in addition to other measures of regional deterrence towards Russia, it is planned to strengthen NATO’s regional missile defense system. The purpose of this article is to determine the potential impact of enhancing NATO’s theater missile defense on regional security. The answer to this question is important for understanding the prospects for European security. This article provides a critical analysis of Western experts’ scenarios of actions of Russia and NATO around the Baltic countries the place and role of theater missile defense in these scenarios and compares the doctrinal guidelines of the United States and Russia regarding regional nonnuclear deterrence. There are situations in which NATO’s enhanced regional missile defense could strengthen regional deterrence, and there are situations where this is less likely. Taking into account the doctrinal guidelines of both sides, conclusions are drawn about the destabilizing potential of NATO’s regional missile defense enhancement and that, in strengthening regional stability, there is no alternative to arms control and transparency regimes.
Subglottic stenosis masquerading as asthma in a young adult: an overlooked and delayed diagnosis
Authors: Whittet Carys , Morris Simon , Pope Laysan
Published: September 2022

An otherwise fit young woman presented with a 10-year history of non-progressive wheeze and ‘noisy breathing’. She had previously been diagnosed with teenage-onset asthma but had been unresponsive to inhaled corticosteroids and bronchodilators. A dysfunctional breathing disorder had been considered a possible diagnosis by several general practitioners, and there were no features to suggest systemic conditions. The patient had undergone an otherwise apparently uncomplicated intubation general anaesthetic for a gastroenterological investigation 13 years earlier. An outpatient flexible endoscopic examination of the upper aerodigestive tract demonstrated an isolated subglottic stenosis which was characterised by cross-sectional imaging. Microlaryngoscopy confirmed a smooth subglottic stenosis which was dilated using a minimally invasive balloon dilatation technique to good clinical effect.
Does persistent precarious employment affect health outcomes among working age adults? A systematic review and meta-analysis
Authors: Pulford Andrew , Thapa Alekh , Thomson Rachel M , Guilding Annette , Green Michael James , Leyland Alastair , Popham Frank , Katikireddi Srinivasa Vittal
Published: September 2022

Objective

To evaluate the impact of persistent precarious employment (lasting 12+ months) on the health of working age adults, compared with more stable employment. Persistent precarity reflects a shift towards less secure forms of employment and may be particularly important for health.

Methods

Nine databases were systematically searched to identify quantitative studies that assessed the relationship between persistent precarious employment and health outcomes. Risk of bias (RoB) was assessed using an adaptation of the Effective Public Health Practice Project tool. Narrative synthesis and random effects meta-analysis were conducted. Certainty of evidence was assessed using the Grades of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Results

Of 12 940 records screened, 50 studies met the inclusion criteria and 29 were included in meta-analyses. RoB was generally high (n=18). The most reported outcome domain was mental health; with evidence also reported relating to general health, physical health,and health behaviours. Of GRADE assessed outcomes, persistent precarious employment was associated with increased risk of poor self-rated health (OR 1.53, 95% CI 1.09 to 2.14, I2=80%) and mental health symptoms (OR 1.44, 95% CI 1.23 to 1.70, I2=65%). The association with all-cause mortality was imprecisely estimated (OR 1.10, 5% CI 0.91 to 1.33, I2=73%). There was very low GRADE certainty across all outcomes.

Conclusions

Persistent precarious employment is associated with poorer health, particularly for outcomes with short time lags, though associations are small and causality is highly uncertain. Further research using more robust methods is needed but given potential health harms of persistent precarious employment, exploration of precautionary labour regulations and employment policies is warranted.
Patient-facing digital tools for delivering genetic services: a systematic review
Authors: Lee Whiwon , Shickh Salma , Assamad Daniel , Luca Stephanie , Clausen Marc , Somerville Cherith , Tafler Abby , Shaw Angela , Hayeems Robin , Bombard Yvonne
Published: September 2022

This study systematically reviewed the literature on the impact of digital genetics tools on patient care and system efficiencies. MEDLINE and Embase were searched for articles published between January 2010 and March 2021. Studies evaluating the use of patient-facing digital tools in the context of genetic service delivery were included. Two reviewers screened and extracted patient-reported and system-focused outcomes from each study. Data were synthesised using a descriptive approach. Of 3226 unique studies identified, 87 were included. A total of 70 unique digital tools were identified. As a result of using digital tools, 84% of studies reported a positive outcome in at least one of the following patient outcomes: knowledge, psychosocial well-being, behavioural/management changes, family communication, decision-making or level of engagement. Digital tools improved workflow and efficiency for providers and reduced the amount of time they needed to spend with patients. However, we identified a misalignment between study purpose and patient-reported outcomes measured and a lack of tools that encompass the entire genetic counselling and testing trajectory. Given increased demand for genetic services and the shift towards virtual care, this review provides evidence that digital tools can be used to efficiently deliver patient-centred care. Future research should prioritise development, evaluation and implementation of digital tools that can support the entire patient trajectory across a range of clinical settings. PROSPERO registration numberCRD42020202862.
Identifying racial disparities in hereditary hemorrhagic telangiectasia
Authors: Yusuf Hamzah , Rasheed Amna , Kim Helen , Conrad Miles B , Hetts Steven W
Published: September 2022

Background

Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant disorder characterized by recurrent epistaxis (nose bleeds), mucosal telangiectasias (spider veins), and arteriovenous malformations. Although HHT affects all racial groups, few studies have explored racial disparities among patients with HHT.

Methods

We performed a retrospective chart review of HHT patients who were seen at a single academic center between July 1, 2014 and January 1, 2022. The primary outcomes of this study were the Epistaxis Severity Score (ESS) and the presence of pulmonary, cerebral, gastrointestinal, spinal, and hepatic arteriovenous malformations (AVMs). We analyzed racial differences using t-tests and analysis of variance (ANOVA) for continuous variables, and chi-squared tests for categorical variables. We then performed multivariable linear and logistic regressions on outcomes.

Results

Our review identified 35 Asian, 6 Black or African American, 72 Hispanic or Latino, and 244 White or Caucasian patients who met the inclusion criteria. Through an analysis of variance model, race/ethnicity was not significantly associated with ESS. Two univariable logistic regression models between race and both pulmonary and brain AVMs showed that race was associated with the incidence of pulmonary AVMs (p<0.01), with Asian patients at a 2.3-fold increased risk of pulmonary AVMs compared with White patients (p=0.03). Race was also associated with the incidence of cerebral AVMs (p<0.01) with Hispanic or Latino patients at a 4.8-fold increased risk compared with White patients (p<0.01).

Conclusion

Patients who identified as Asian may have higher rates of pulmonary AVMs while patients identifying as Hispanic or Latino may have more cerebral AVMs. The correlations may be important for identifying risk factors in certain patient populations.
Braids for unoriented Pretzel links
Authors: del Pozo Manglano Ángel , Manchón Pedro M. G.
Published: September 2022

We give a procedure that provides, given any unoriented pretzel link [Formula: see text], a braid whose closure is [Formula: see text]. Moreover, we give a specific braid word in terms of the entries of the pretzel link.
EFFECTS OF NON-REDUNDANCY AMONG TIES ON RECOMBINANT CAPABILITIES
Authors: ZHAO JIANYU , FU CHENG
Published: September 2022

This study explores the impacts of non-redundancy among ties in collaboration and knowledge networks on diverse recombinant capabilities by examining the moderating effects of both knowledge similarity and knowledge complementarity. By using 3,293 patent data in the graphene field of China, we found that non-redundancy among ties in a collaboration network positively affected both recombinant creation capability and recombinant reuse capability. However, non-redundancy among ties in a knowledge network was found to favour recombinant creation capability but hinder recombinant reuse capability. Moreover, the effects of non-redundancy among ties in different networks on recombinant capabilities depended on knowledge similarity and knowledge complementarity. These findings not only reveal the role of non-redundancy among ties on recombinant capabilities, but also highlight the significance of knowledge similarity and knowledge complementarity in the relationship between non-redundancy among ties and recombinant capabilities, thereby providing fresh insights into how to improve organisational recombinant capabilities
Aβ Protein Detector Based on AAO Confined Self-Assembly System
Authors: Xu Chao , Lu Mengyang , Xu Weiran , Xiong Xudong , Fan Zhao , Wang Yongqian
Published: September 2022

With the advent of the aging of the world’s population, the number of patients suffering from Alzheimer’s disease (AD) is increasing year by year, and how to diagnose early and treat AD has become a problem for the world. After decades of hard work, people have made a series of breakthroughs in the pathogenesis of AD. One of the most widely accepted is that there is a large amount of amyloid-[Formula: see text] protein deposition in the body of AD patients. This also provides us with a new idea for early diagnosis of AD. In this paper, a confined self-assembly system based on AAO/ZnS is constructed to specifically respond to amyloid-[Formula: see text] protein. The obtained samples were characterized by FESEM, XPS and UV–Vis. This system specifically recognizes A[Formula: see text] protein by modifying the tryptophan enantiomers. The experimental results show that the samples synthesized under the self-assembly system of modified D-Trp have higher response sensitivity to amyloid-[Formula: see text] protein. This provides a new idea for the self-assembly system based on the limited space of the nano-biomimetic channel in biological detection, and also shows great potential in improving the sensitivity of the biodetector.
Lidstone interpolation II. Two variables
Authors: Waldschmidt Michel
Published: September 2022

According to Lidstone’s interpolation theory, an entire function of a single variable of exponential type [Formula: see text] is determined by it derivatives of even order at [Formula: see text] and [Formula: see text]. In a previous paper, we gave a survey of this classical univariate theory. Here, we generalize it to two variables. Multivariate Lidstone interpolation will be the topic of a forthcoming paper.
Complete decomposition of dihedral groups with application to key exchange protocol
Authors: Wong Denis C. K.
Published: September 2022

In this work, we perform an investigation on the hardness of finding complete decompositions of dihedral groups and show an application of complete decomposition by constructing a Diffie–Hellman-type key exchange protocol.
Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma
Authors: Huang Guimei , Wang Jiayi , Li Lei , Gao Yuan , Yan Yijie
Published: September 2022

Objective. We aimed to explore the effect of blood lipid parameters on the risk of primary open-angle glaucoma (POAG) by meta-analysis. Methods. The databases of PubMed, Scopus, CNKI, and Wanfang were systematically searched from inception to April 2022, and the relevant research literature was obtained, screened, and analyzed. Results. A total of 15 studies were included in this meta-analysis, including 11 reporting dyslipidemia and risk of POAG and 5 reporting specific lipid level and risk of POAG. Dyslipidemia increased the risk of POAG with an odd ratio (OR) of 1.25 (95% CI: 1.23, 1.26). Total triglyceride and total cholesterol were not related to the prevalence of POAG, but high-density lipoprotein cholesterol was significantly negatively correlated with the risk of POAG with an OR of 0.96 (95% CI: 0.94, 0.99). Conclusion. Dyslipidemia is a risk factor for POAG. Given the small sample size and significant interstudy heterogeneity, additional studies are needed to establish this conclusion.
Influence of Future Material Nano‐ZrO2 and Graphene on the Mechanical Properties of Al Composites
Authors: Umar MD. , Muraliraja R. , Shaisundaram V. S. , Wayessa Shiferaw Garoma
Published: September 2022

Recent developments in mechanical applications have led to the development of metal matrix composites, which represent the future of composite structures. Al7010 aluminium alloy matrix with nano‐ZrO2 and graphene particle reinforced composite is created in this experiment. By adopting the stir casting procedure in two different casting, 2 percent reinforcement of zirconium dioxide and 1 percent of graphene is included in the composite materials. The composite’s metallurgical and mechanical characteristics are studied. The SEM image demonstrates uniform dispersion of the particles in the alloy matrix. The manufactured material’s ability to gather particulate matter is clearly found in SEM and EDS. The addition of zirconia particles works together to prevent the alloy matrix from dislocating, which increases the base material’s hardness as well as its tensile resistance. Similar results are also found in graphene‐casting material. Results from tensile tests reveal that adding nano‐zirconium dioxide particle (ZrO2) and graphene boosts the material’s tensile and hardness strength. In terms of the ultimate tensile strength (UTS), the Al7010/2% ZrO2 composite had a 6% increase and Al7010/1% graphene had a 5.5% increase above the Al7010 alloy. Compared to Al7010 alloy, the microhardness of Al7010/ZrO2 is 17.64% greater and Al7010/1% graphene is 14% greater.
The Prediction Value of D-Dimer on Prognosis in Intensive Care Unit among Old Patients ( ≥65 Years): A 9-Year Single-Center Retrospective Study of 9261 Cases
Authors: Lian Hui , Cai Huacong , Zhang Hongmin , Ding Xin , Wang Xiaoting , Zhang Shuyang
Published: September 2022

Background. D-dimer (DD) has been indicated as a potential indicator due to its connection with the prognosis of the COVID-19 pandemic. Aging is linked to elevated DD levels in coagulation activation. However, few studies have investigated the correlation of DD with prognosis, especially in the old population. Therefore, this study aims at investigating the correlation of DD with prognosis in shock and perioperative populations over 65 years of age. Methods. We analyzed 9261 old patients admitted to intensive care units (ICUs) with either confirmed shock or in perioperative period of high-risk surgery, with 8813 of them had DD levels determined on admission. In-hospital mortality, length of ICU stay and ventilation time (VT) associated variables were assessed using generalized linear models. Results. Although DD levels had no positive correlations with in-hospital mortality (RR, 1.006; 95% CI, 0.998-1.014) and length of ICU stay (RR, 1.012; 95% CI, 0.997-1.028) in Model 3, they were strongly correlated with VT (RR, 1.577; 95% CI, 1.024-2.064). Higher DD levels in females (RR, 1.804; 95% CI, 1.116-2.602), those who used antibiotics (RR, 1.736; 95% CI, 1.092-2.453), those with surgery (RR, 1.640; 95% CI, 1.273-2.114), and those with shock (RR, 1.740; 95% CI, 1.001-2.687) had stronger correlation with longer VT than the counterparts. While patients who were between 65 and 74 years old (RR, 1.023; 95% CI, 1.003–1.043), with no use of antibiotics (RR, 1.007; 95% CI, 1.001–1.013) nor shock (RR, 1.011; 95% CI, 1.002–1.021), but had undergone surgical procedures (RR, 1.030; 95% CI, 1.012–1.048) were correlated with a longer ICU length of stay. Conclusion. DD levels at ICU admission are highly related to increased VT and length of ICU stay in the old population with either confirmed shock or after high-risk surgery, indicating the strong potential of DD as a marker with prognostic utility for all ICU patients in the future.
Data Management and Service Mode of Library Based on Data Mining Algorithm
Authors: Zhang Jingjing , Chi Yang
Published: September 2022

Data management for large-scale data library services with mining procedures improves the availability and readiness of heterogeneous sources. The heterogeneous data sources are assimilated as a single entity through mining procedures to meet the data demands. This article introduces connectivity-persistent data mining method (CDMM) to improve the data handling precision with boosting availability. The proposed method relies on federated learning for identifying the service demands, thereby providing data mining. The learning paradigm accumulates information on shared data library existence over various services. Based on the availability, further mining demands are forwarded to the data management system. If the existence verified by the federated learning is adaptable, then sharing-enabled mining is endorsed for the connected users. The data management then augments several heterogeneous shared libraries to meet the mining requirements. This process is reversible based on the service mode and existence. Therefore, the proposed method improves data availability with less mining and access time and fewer failures.
Development of a Novel Inflammatory-Associated Gene Signature and Immune Infiltration Patterns in Intervertebral Disc Degeneration
Authors: Lan Tao , Hu Zhihao , Guo Weizhuang , Yan Bin , Zhang Yuantao
Published: September 2022

Background. Both inflammatory factors and immune response play important roles in the pathogenesis of intervertebral disc degeneration (IDD). However, a comprehensive analysis of interaction between inflammatory response-associated genes (IRGs) and immune microenvironment in patients with IDD remains lacking. Hence, the current research is aimed at investigating the correlations between IRG signatures and immune cells in the progression of IDD. Methods. The expression profiles (GSE27494 and GSE41883) and IRGs were downloaded from the Gene Expression Omnibus (GEO) database and Molecular Signature Database (MSigDB), respectively. Weighted gene coexpression network analysis (WGCNA) and differential expression analysis were used to identify the pivotal modules and common differentially expressed genes (DEGs) associated with IDD. Subsequently, we retrieved differentially expressed IRGs (DE-IRGs) by intersecting IRGs and DEGs for enrichment analysis. Next, LASSO regression analyses were performed to screen optimal marker genes for IDD prediction. Additionally, we validated differences DE-IRGs between IDD patients and controls in GSE150408. Finally, the infiltration alteration of immune cells was evaluated by the CIBERSORT, and the correlation between diagnostic markers and infiltrating immune cells was analyzed. Results. A total of 10 upregulated differentially expressed inflammatory genes were identified that were obviously related to progression of IDD. Functional analysis results revealed that DE-IRGs were mainly enriched in signaling pathways TNF, IL-17, NOD-like receptor, and NF-kappa B pathway. A five-gene signature that consisted of IL-1β, LIF, LYN, NAMPT, and SLC7A2 was constructed by the LASSO Cox regression. IL1B, LYN, and NAMPT were further validated as optimal candidate genes in the pathophysiology of IDD. In addition, there was a remarkable immune cell infiltration difference between the healthy and IDD groups. The proportions for dendritic cells activated, mast cells activated, and neutrophils in the IDD group were significantly higher than those in the normal group, while the proportion of some cells was lower than that of the normal group, such as T cell CD4 memory resting, NK cells activated, and macrophage M0. Furthermore, correlation analysis indicated IL-1β, LYN, and NAMPT were closely implicated with immune cell infiltration in IDD development. Conclusions. We explored an association between inflammatory response-associated signature and immune infiltration in IDD and validated that IL-1β, LYN, and NAMPT might serve as biomarkers and therapeutic targets for IDD in the future.
Explore on Online English Listening Evaluation System Using the Genetic Algorithm
Authors: Yin Shiyu , Xu Jin , Ge Liying
Published: September 2022

Testing is a good teaching tool. The online testing system can realize automatic aggregation, scoring, statistics, and analysis of test questions, which saves a lot of time and money for the organizers and participants, and is an effective means to promote the modernization of education in China. The purpose of implementing English intelligence is to allow teachers and students to make better use of their strengths in the English learning process and to improve English teaching based on the results of quantitative analysis of intelligence, which will play a positive role in promoting quality language education in secondary schools, thus truly reducing the burden on teachers and students. The genetic algorithm is an intelligent algorithm based on natural selection and genetic variation in the world of bionic organisms. It has the remarkable advantages of simplicity and generality, robustness, parallel processing, efficiency, and practicality, and has been widely used in automation and other fields with good results. The method can effectively overcome the traditional problems of slow grouping speed, low success rate, and poor grouping quality. The system is scientific, reasonable, and practical and can meet the needs of users to the maximum extent.
The Role of Mitochondrial Quality Control in Anthracycline-Induced Cardiotoxicity: From Bench to Bedside
Authors: Li Yukun , Lin Rong , Peng Xiaodong , Wang Xuesi , Liu Xinmeng , Li Linling , Bai Rong , Wen Songnan , Ruan Yanfei , Chang Xing , Tang Ribo , Liu Nian
Published: September 2022

Cardiotoxicity is the major side effect of anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin), though being the most commonly used chemotherapy drugs and the mainstay of therapy in solid and hematological neoplasms. Advances in the field of cardio-oncology have expanded our understanding of the molecular mechanisms underlying anthracycline-induced cardiotoxicity (AIC). AIC has a complex pathogenesis that includes a variety of aspects such as oxidative stress, autophagy, and inflammation. Emerging evidence has strongly suggested that the loss of mitochondrial quality control (MQC) plays an important role in the progression of AIC. Mitochondria are vital organelles in the cardiomyocytes that serve as the key regulators of reactive oxygen species (ROS) production, energy metabolism, cell death, and calcium buffering. However, as mitochondria are susceptible to damage, the MQC system, including mitochondrial dynamics (fusion/fission), mitophagy, mitochondrial biogenesis, and mitochondrial protein quality control, appears to be crucial in maintaining mitochondrial homeostasis. In this review, we summarize current evidence on the role of MQC in the pathogenesis of AIC and highlight the therapeutic potential of restoring the cardiomyocyte MQC system in the prevention and intervention of AIC.
Improve Performances of Wireless Sensor Networks for Data Transfer Based on Fuzzy Clustering and Huffman Compression
Authors: Molk Ali Mohammad Norouzzadeh Gil , Ghoreishi Seyed Mohsen , Ghasemi Fatemeh , Elyasi Iraj
Published: September 2022

In today’s world, the main challenge is to save use energy optimally. The IoT devices generate a large amount of data for wide applications. Considering the application perspective in the IoT market, in one instance of the IoT technology, that is a wireless sensor network, factors like energy, storage capacity, computation power, and limitations of communication bandwidth resources are the reason for using data fusion. Data fusion and aggregation in wireless sensor networks (WSNs) such that minimum energy is consumed are an essential issue. In most clustering models, data aggregation is carried out by the cluster-head (CH). In the proposed algorithm, data aggregation in the cluster-head is carried out using the lossless cascode Huffman compression algorithm. Due to the correlation among data of nodes, the data sensed by each node is compared with the data of the cluster-head node; after removing redundancy, the coded data is transmitted to the main node. The CH node is selected by an algorithm based on fuzzy logic according to the residual energy of the node and the distance of the node from the sink node. Various fuzzy type-I systems of Mamdani and Takagi-Sugeno and type-II systems are used. In this paper, the CH selection algorithms are evaluated using three scenarios in terms of the number of live nodes, received packets and CHs, proper distribution rate, and other parameters of the LEACH protocol, network lifetime, and network energy. In the following, to demonstrate the performance of this new algorithm, simulations are performed in MATLAB based on the proposed method. The results show that the proposed compression algorithm in environments with high data correlation improves the compression rate by 8% compared to the conventional Huffman compression, while in environments with low data correlation, these two algorithms perform almost the same. This compression helps reduce the energy consumption of the network.
Short-Term Power Prediction of a Photovoltaic Power Station Based on the SSA-CEEMDAN-FCN Model
Authors: Qu Zhaoyang , Qin Shaohua , Xiong Genxin , Zhu Xinpo , Ling Fan , Wang Yukun , Kong Juan
Published: September 2022

Photovoltaic power generation is greatly affected by weather factors. To improve the prediction accuracy of photovoltaic power generation, complete ensemble empirical mode decomposition with an adaptive noise algorithm (CEEMDAN) is proposed to preprocess the power sequence. Then, the full convolutional network (FCN) model optimized based on the sparrow search algorithm (SSA) is used to predict the short-term photovoltaic power. SSA can more reasonably determine the parameters of FCN and improve the prediction performance of FCN. Therefore, the FCN model optimized by the SSA algorithm is used to establish prediction models for subsequences and predict each subsequence, respectively. Finally, the predicted value of each subsequence is superimposed. Taking the actual data of a photovoltaic power station in Jiangsu province of China as an example, by comparing some different common prediction models, it is proved that the proposed method is reasonable and feasible.
Design and Implementation of Financial Management System Based on Computer Network Technology
Authors: Yan Jianwei
Published: September 2022

At present, financial management systems have been applied in many universities. University’s usage of the financial management system to achieve ideal results in formulating financial plans, strengthening financial control, and improving the efficiency of financial management. The healthy and long-term development of a university is inseparable from scientific financial management methods. With the rapid development of computer technology, the use of financial management tools is an effective way to improve the quality of financial management. The article applies computer network technology to the financial management system. The main functions of the financial management part and the accounting management part of the system are set as data recording and data statistics display. The financial management system combines the financial management of the university with the informatization of the industry, which realizes the computerization of accounting, and replaces the traditional manual financial mode. The results show that the average response time, data throughput per second, and number of requests per second of the transformed system are higher than those of the untransformed traditional system, and the ratio is about 5% higher. This shows that the financial management system constructed by the computer network technology can play a certain role in the operation of the university.
Data Analysis of the Effect of Different Nanomaterials on Antislide Pile Performance in Railway Landslides
Authors: Guo Kai , Zheng Mingxin , Ren Yongjiang
Published: September 2022

Engineering geological conditions in our country are complex and diverse. Many high-rise buildings, bridges, and launch towers are inevitably built on high and steep slopes. Heavy rain, earthquake, human engineering activities, and other factors lead to frequent landslides, soil creep deformation, and overall sliding, resulting in a certain bending moment and flexural deformation of foundation piles, may cause damage to the substructure and foundation pile failure, and then endanger the safety of the superstructure. In the past, bridge pile group foundation was used in bridge pile foundation engineering to improve the impact situation, but the stress environment of bridge pile foundation in landslide is obviously different from that of bridge pile foundation in the flat area. The large deformation of soil in front of the pile will easily cause the phenomenon of soil sliding and peeling, which will increase the technical difficulty of antislide pile construction. Based on this, this study firstly briefly introduces the relevant theories and technologies of railway landslide antislide pile technology and then establishes the static model of railway landslide antislide piles with different nanomaterials. Finally, the reinforcement technology of different nanomaterial antislide piles for railway landslide is expounded, which can provide guarantee for the application of different nanomaterial antislide piles for railway landslide. The results show that the preloading is carried out according to 1/10 of the design load to reduce the void between the soils. After the load is maintained for 2 hours, the load is unloaded to 0, and good skid resistance can be obtained.
A Method of Improving College Students’ Physical Fitness Test Based on Fuzzy Comprehensive Evaluation of Information Fusion
Authors: Chang Liang , Zhang Xinghua
Published: September 2022

For the evaluation of college students’ physical health, the

t

-test, one-way ANOVA test, fuzzy comprehensive evaluation, and other methods were used to establish the models of back generation test, ANOVA, and fuzzy comprehensive evaluation; and Matlab, Excel, VBA, and other software programming were used to derive the significant influence of body weight on college students’ physical health, no significant difference of students’ physical health in different places of birth and the comprehensive score of college students’ physical health. The results such as the comprehensive score of health evaluation were used to analyze the physical health test results of college students in Zhuzhou city colleges and universities in the context of the promulgation of the new Student Physical Health Standard and several higher school sports policies by using the fuzzy comprehensive evaluation method to comprehensively grasp the physical health condition of students and provide reference for school sports reform and students’ physical exercise. Conclusion. The current situation of physical health of college students in Zhuzhou City is less satisfactory, and most of the students’ physical test results are concentrated in the passing area, with fewer students with excellent and good proportions. The policy changes, system construction, implementation, and students’ attitudes were analyzed, and solution measures were proposed to intervene in time to turn the situation around and improve students’ physical health.
Syphilis-Associated Proteinuria and Hepatitis in the Setting of Human Immunodeficiency Virus (HIV) Co-Infection
Authors: Jain Hanish , Singh Garima , Asiago-Reddy Elizabeth
Published: September 2022

Syphilis has long been known as “the great imitator”, mimicking a wide variety of diseases, and often its diagnosis is delayed or missed. It remains an important public health issue that continues to occur at high rates among patients with HIV. We report a case of a 52-year-old man who presented with a constellation of unusual symptoms highlighting that syphilis should be included in the differential diagnosis in patients with HIV presenting with abnormal liver enzymes, rash, proteinuria, conjunctivitis, and/or sexual risk factors.
miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair
Authors: Cheng Yu-Wen , Lin Chien-Ju , Kuo Shih-Hsun , Lieu Ann-Shung , Chai Chee-Yin , Tsai Hung-Pei , Kwan Aij-Lie
Published: September 2022

Background. Glioblastoma multiforme (GBM) is one of the most deadly and recalcitrant illnesses of the neurocentral nervous system in humans. MicroRNAs (miRNAs) are a class of noncoding RNAs that play important roles in the regulation of gene expression and biological processes, including radiosensitivity. In this study, we demonstrated the relationship between miR-3059-3p and radiation in GBM. Materials and Methods. Radioresistant (RR) cells were obtained by exposing GBM8401 cells to 80 Gy radiation in 20 weekly 4 Gy fractions. miR-3059-3p mRNA and DNA replication helicase/nuclease 2 (DNA2) protein expressions were detected using real-time polymerase chain reaction and immunoblotting. Using flow cytometry, colony formation and apoptosis were identified using miR-3059-3p mimic, miR-3059-3p inhibitor, DNA2 siRNA, and DNA2 plasmid. Immunoblotting was used to detect DNA repair proteins. Results. Low levels of miR-3059-3p and high levels of DNA2 were observed in RR cells. Colony formation and apoptosis assays revealed that miR-3059-3p targeted DNA2 to regulate radioresistance. Immunoblotting revealed that miR-3059-3p regulated the homologous recombination (HR) pathway (Rad51 and Rad52) but not the nonhomologous end joining pathway (ku70 and ku80). Conclusion. Downregulation of DNA2 via miR-3059-3p enhanced the radiosensitivity of GBM cells through the inhibition of the HR pathway.
Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells
Authors: Cao Xiankun , Wang Xin , Rong Kewei , Liu Kexin , Yang Xiao , Zhou Tangjun , Zhang Pu , Guo Jiadong , Ma Hui , Qin An , Zhao Jie
Published: September 2022

Intervertebral disc (IVD) degeneration (IVDD) is a characteristic of the dominating pathological processes of nucleus pulposus (NP) cell senescence, abnormal synthesis and irregular distribution of extracellular matrix (ECM), and tumor necrosis factor-α (TNF-α) induced inflammation. Nowadays, IVD acid environment variation which accelerates the pathological processes mentioned above arouses researchers’ attention. KAN0438757 (KAN) is an effective inhibitor of selective metabolic kinase phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) that has both energy metabolism reprogramming and anti-inflammatory effects. Therefore, a potential therapeutic benefit of KAN lies in its ability to inhibit the development of IVDD. This study examined in vitro KAN toxicity in NP primary cells (NPPs). Moreover, KAN influenced tumor necrosis factor-α (TNF-α) induced ECM anabolism and catabolism; the inflammatory signaling pathway activation and the energy metabolism phenotype were also examined in NPPs. Furthermore, KAN’s therapeutic effect was investigated in vivo using the rat tail disc puncture model. Phenotypically speaking, the KAN treatment partially rescued the ECM degradation and glycolysis energy metabolism phenotypes of NPPs induced by TNF-α. In terms of mechanism, KAN inhibited the activation of MAPK and NF-κB inflammatory signaling pathways induced by TNF-α and reprogramed the energy metabolism. For the therapeutic aspect, the rat tail disc puncture model demonstrated that KAN has a significant ameliorated effect on the progression of IVDD. To sum up, our research successfully authenticated the potential therapeutic effect of KAN on IVDD and declaimed its mechanisms of both novel energy metabolism reprogramming and conventional anti-inflammation effect.
Impact of Multiplicative Noise on the Exact Solutions of the Fractional‐Stochastic Boussinesq‐Burger System
Authors: Mohammed Wael W. , Al-Askar Farah M. , El-Morshedy M.
Published: September 2022

In this paper, we consider the fractional‐stochastic Boussinesq‐Burger system (FSBBS) generated by the multiplicative Brownian motion. The Jacobi elliptic function techniques are used to create creative elliptic, hyperbolic, and rational fractional‐stochastic solutions for FSBBS. Furthermore, we draw 2D and 3D graphs by using the MATLAB Package for some obtained solutions of FSBBS to discuss the influence of the Brownian motion on these solutions. Finally, we indicate that the Brownian motion stabilizes the solutions of FSBBS around zero.
Design of Urban Garden Landscape Visualization System Based on GIS and Remote Sensing Technology
Authors: Zhang Wenpeng
Published: September 2022

Urban green ecological space is an important manifestation of the environmental characteristics of a green city. The research results show that the urban green ecological space has obvious cooling and humidity effects, which are very important for reducing the urban heat island effect. Remote sensing technology describes the slow-release effects of urban green parks in different seasons from the two perspectives of thermal slow-release intensity and thermal slow-release distance. In this paper, UAV remote sensing is used to extract the internal and external factors of the urban green environment characteristics and to identify the main factors that affect the slow-release heat effect and seasonal changes of the urban green environment. In addition, it analyzes the factors that affect the urban environmental temperature within the environmental temperature slow-release range of urban green space, establishes a model to predict the environmental temperature within the thermal slow-release range outside the park, and realizes the largest thermal slow release in the urban greening ecological space. These are new technologies created in the context of digitization, which include image understanding and synthesis, which involve the use of computer graphics and image processing technology to convert data into graphics or images displayed on the screen to achieve an interactive process.
The Coffee Processing Method Had a More Pronounced Effect than Location and Production Systems on the Overall Quality of Kaffa Biosphere Reserve Coffees
Authors: Alemayehu Tassew Addis , Berecha Yadessa Gezahegn , Debela Bote Adugna , Obso Taye Kufa
Published: September 2022

A comprehensive examination of the physical and cup quality of Kafa Biosphere Reserve coffees was essential to identify the inherent qualities of the coffees in connection with the area’s soil physical and chemical characteristics. As a result, preliminary coffee quality data was acquired from bean physical and cup quality examination of coffees derived through a three-stage nested design combining districts (Gimbo, Gawata, and Decha), coffee production systems (forest, semiforest, and garden), and coffee processing methods (wet, semiwet, and dry). Representative soil samples were collected according to the sampling structure and analyzed following the standard procedures. Multiple factor analysis and Pearson’s correlation coefficient analysis were applied to the collected data. According to the results of multiple factor analysis, the Gimbo and Decha districts are not significantly different from each other in terms of coffee quality. However, they are substantially different from the Gawata district in terms of coffee quality. Similarly, within each district, there are no clear differences in coffee production systems. However, the production systems of districts varied significantly. The coffee processing method had a pronounced effect on the overall quality and preliminary grade, physical and raw quality variables of coffee. Screen retention (14) was correlated with soil iron, but it was related negatively to boron and sodium contents. A significant and positive relationship was observed between green coffee bean moisture content and soil potassium, calcium, magnesium, boron, sodium, organic carbon, silicon content, and soil pH. A positive and significant relationship between soil molybdenum and the coffee quality variable was observed across the studied districts whereas most soil micronutrients, specifically, zinc, sulfur, and manganese, were significantly and negatively related to the organoleptic qualities of the coffees. Further investigation that includes the effects of elevation is recommended in future studies.