bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacillus velezensis LG37: Transcriptome profiling and functional verification of GlnK and NmtA in ammonia (NH4+) assimilation
Authors: Liu Guangxin , V Sarath Babu , Dong Yanjun , Zhao Lijuan , Li Xinfeng , Tu Jiagang , He Jin , Lin Li
Published: September 2019

Background In recent years, interest in Bacillus velezensis has increased considerably due to its ability in many industrial water treatment bioremediation processes that including aquaculture practice as probiotics. In this study, we isolated and assessed the transcriptome genes expression levels under different nitrogen source from a new Bacillus velezensis LG37 strain isolated from the aquaculture pond water. Since the Bacillus species are determined to exhibit heterogeneity, and the underlying molecular mechanisms remain poorly understood in ammonia nitrogen assimilation, where ammonia nitrogen considered as toxic to aquatics.Results Here, a total of 812 differentially expressed genes (DEGs) from the transcriptomic sequencing of LG37 grown with ammonia or glutamine, from which 56 genes obtained with Fold Change ≥ 2 through BLAST NCBI and UniProt database that displayed 27 DEGs potentially involved in NH4+ assimilation. Among them, the relative expression level of the two-component regulatory system glnK/glnL were significantly upregulated in the transcriptomic profile, and the same was authenticated for their consistency by RT-qPCR along with six other genes. In addition, the transcriptome and relative expression analysis showed that the transporter (amtB) gene of LG37 was not in favor of ammonia transport even in the highest ammonia concentrations. Besides, CRISPR-Cas9 knockout (Δ) and overexpression (OE) LG37 mutants of glnK evidenced the exclusion of amtB regulation, suggesting an involvement of alternative transporter. Moreover, the transcriptomic data exhibited a novel ammonium transporter nmtA that expressed significantly in the expanding ammonia concentrations. Subsequently, OEnmtA and ΔnmtA LG37 strains showed a unique expression pattern compared to that of wild-LG37 strain.Conclusion Based on the transcriptome data, regulation of nitrogen related genes were promptly screened from the newly isolated LG37 strain to analyse the key regulating factors during ammonia assimilation. The novel NmtA transporter of LG37 became apparent in ammonia transport instead of AmtB, which transport ammonium nitrogen in other Bacillus strains, with the aid of the genomic editing tools. The validated NmtA and other transcriptome predicted data would shed a new light on the assimilation mechanism of ammonia, and the isolate can be broadly applicable to facilitate the removal of ammonium nitrogen.
Patient attitudes towards faecal sampling for gut microbiome studies and clinical care reveal positive engagement and room for improvement
Authors: Bolte Laura A. , Klaassen Marjolein A.Y. , Collij Valerie , Vila Arnau Vich , Fu Jingyuan , Meulen Taco A. van der , de Haan Jacco J. , Versteegen Gerbrig J. , Dotinga Aafje , Zhernakova Alexandra , Wijmenga Cisca , Weersma Rinse K. , Imhann Floris
Published: September 2019

Background: Faecal sample collection is crucial for gut microbiome research and its clinical applications. However, while patients and healthy volunteers are routinely asked to provide stool samples, their attitudes towards sampling remain largely unknown. Here we investigate the attitudes of 780 Dutch patients, including participants in a large Inflammatory Bowel Disease (IBD) gut microbiome cohort, and population controls, to identify barriers to sample collection and provide recommendations for gut microbiome researchers and clinicians. Methods: We sent questionnaires to 660 IBD patients and 112 patients with other disorders who had previously been approached to participate in gut microbiome studies. We also conducted 478 brief interviews with participants in our general population cohort who had collected stool samples. Statistical analysis of the data was performed using R. Results: 97.4% of respondents reported that they had willingly participated in stool sample collection for gut microbiome research, and most respondents (82.9%) and interviewees (95.6%) indicated willingness to participate again, with motivations for participating being mainly altruistic (57.0%). Responses indicated that storing stool samples in the home freezer for a prolonged time was the main barrier to participation (52.6%), but clear explanations of the sampling procedures and their purpose increased willingness to collect and freeze samples (P=0.046, P=0.003). Conclusions: To account for participant concerns, gut microbiome researchers establishing cohorts and clinicians trying new faecal tests should provide clear instructions, explain the rationale behind their protocol, consider providing a small freezer, and inform patients about study outcomes. By assessing the attitudes to, motives for and barriers to participation in faecal sample collection, we can provide important information that will contribute to the success of gut microbiome research and its near-future clinical applications.
Pregnancy Outcomes of Patients with Acute Fatty Liver of Pregnancy
Authors: Chang Lingzhi , Wang Ming , Liu Haixia , Meng Qinghua , Yu Hongwei , Wu Yu-mei , Zhu Yunxia
Published: September 2019

Background: Limited data exists regarding the pregnancy and infant outcomes of Acute Fatty Liver of Pregnancy (AFLP).Methods: Retrospectively collect the mothers with AFLP and without AFLP in our center from 1/2008 to 6/2018.The primary assessment was to analyze and compare the frequency of negative maternal and fetal outcomes. The secondary assessment was to identify the predictors of negative maternal and fetal outcomes. Results: Compared to 220 matched mothers, 55 AFLP mothers were younger (P<0.001 ), fewer pregnancies(P=0.033),with more pregnancy induced hypertension(P<0.001), twins(P=0.002), fetal growth restriction(P=0.044) and fetus male (P<0.001). 3 (5.5%) of AFLP patients were diagnosed in the postpartum period. The mean gestational ages were 35.25±5.80 weeks at diagnosis of AFLP before delivery and Jaundice(89.1%), nausea or vomitting(58.2%), anorexia(49.1%), fatigue(45.5%) and like cold drinks(30.9%) were the main prodromal symptoms. The median duration from diagnosis to delivery was 1.55±4.62 days and 75%(39/52) patients terminate the pregnancy at the day of diagnosis. 78.8%(41/52) patients received cesearean section for terminating the pregnancy. 53.6%(22/41) patients received preventive plasma transfusion before the surgery and no one received artificial liver support during the treatment. In comparison, higher frequency of 16 maternal complications, severe negative outcomes (27.3% vs. 0.9%) and newborn asphyxia (24.6% vs.0.9%) were observed in AFLP population. 3 mothers (mortality rates: 5.5% ) died of multiple organ system failure and 6 fetal/infant (death rates: 9.8%) died of distress. When compared to those without negative outcomes, younger mothers(P=0.042),more singleton rates (p=0.041),increased mean value of ALT(P=0.011) and T-Bilirubin(P=0.014), decreased prothrombin activity(P=0.011) were predictors of the negative fetal outcomes. Although no statistical significance for the small sample size, the occurence of refractory postpartum hemorrhage (0% vs.31.3% ), hysterectomy(0% vs.12.5% ), negative marternal outcomes (16.7% vs.56.3% ) were significantly decreased in patients with postpartum hemorrhage exceeded 500ml. Conclusions: Several symptoms were found to be the main prodromal symptoms of AFLP. Higher frequency of adverse maternal and fetal outcomes was observed in mothers with AFLP than common people.We found five potential risk factors of negative fetal outcome. Intrauterine balloon pressure might prevent further postpartum bleeding , but need further verification.
ATLANTIS: An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in patients with metastatic urothelial cancer
Authors: Fulton Ben , Jones Robert , Powles Thomas , Crabb Simon , Paul James , Birtle Alison , Chowdhury Simon , Hussain Syed , Morris Anna , Soulis Eileen , Morrison Paula
Published: September 2019

Background Metastatic urothelial cancer (UC) is the eighth most common cause of cancer death in the UK. Standard first-line treatment, for most patients, is cytotoxic chemotherapy. Although UC is initially sensitive to chemotherapy, relapse is almost inevitable after which outcomes are poor, with median overall survival 8 months. There is, therefore, an urgent need for novel therapies to improve outcomes for this patient group.Methods ATLANTIS is a randomised phase II, adaptive design trial of maintenance therapy in biomarker defined subgroups of patients with advanced UC. The primary end-point is progression-free survival (PFS) and the study involves over 30 UK cancer centres. Discussion ATLANTIS is the first study in the UK to employ a precision medicine approach to UC patients for maintenance treatment. Agents with positive efficacy signal will proceed to randomised phase III trials to confirm activity of novel biologically stratified therapies in UC.
Paracetamol (acetaminophen) route in palliative care (PC) patients: Intravenous versus subcutaneous route pharmacokinetics study protocol for a randomized pilot trial = ParaSCIVPallia
Authors: Vernant Marine , Lepoupet Marie , Creveuil Christian , Alix Antoine , Gourio Charlotte , Peyro-Saint-Paul Laure , Lelong-Boulouard Veronique , Guillaumé Cyril
Published: September 2019

Background :Among palliative care patients, the subcutaneous route is often an alternative to the intravenous route, yet pharmacological and clinical data are lacking. Many French palliative teams are now empirically using paracetamol by the subcutaneous route, but there are no data to support this practice. Aim :Compare pharmacokinetic parameters between the intravenous and subcutaneous routes for PC patients. Design : A randomized, open, crossover study in two palliative care centres. The primary endpoints are AUC0-t, AUC0-∞, Cmax, and Vd et t1/2. All adverse events will be reported for a safety analysis. Setting/participants 20 adult palliative care patients with an IV device, having spontaneous pain, not related to care, with a numeric pain rate scale > 3/10, or having a systematic prescription of paracetamol in the usual treatment. They also have to meet all eligibility criteria. Conclusion : First pilot study comparing paracetamol intravenous versus subcutaneous route pharmacokinetics.
Intra-eruptive trachyte-phonolite transition: Natural evidence and experimental constraints on the role of crystal mushes
Authors: Brenna Marco , Pontesilli Alessio , Mollo Silvio , Masotta Matteo , Cronin Shane J. , Smith Ian E.M. , Moufti Mohammed Rashad Hassan , Scarlato Piergiorgio
Published: September 2019

The generation of silica undersaturated phonolite from silica saturated trachytes is uncommon, as it implies the crossing of the thermal barrier and critical plane of silica undersaturation. Nevertheless, a co-genetic suite displaying compositional transition from benmoreite-trachyte to phonolite has been observed within the Al Shaatha pyroclastic sequence in the Harrat Rahat Volcanic Field (Kingdom of Saudi Arabia). We performed crystallization experiments on benmoreite and trachyte starting compositions to simulate the pressure-temperature-volatile conditions that generated the observed liquid line of descent. The experimental conditions were 200–500 MPa, 850–1150 °C, 0–10 wt% H2O, 0.0–0.5 wt% CO2, and NNO+2 oxygen buffer. The experimental mineral assemblage consists of clinopyroxene, feldspar, and titanomagnetite, as well as glass in variable proportions. The degree of crystallinity of hydrous runs is lower than that of anhydrous ones at analogous pressure and temperature conditions. Clinopyroxene crystallizes with compositions diopside-augite and augite-hedenbergite, respectively, at 500 and 200 MPa. The saturation of feldspar is primarily controlled by temperature and volatile content, with the more potassic composition equilibrating at low temperature (850–900 °C) and anhydrous (for benmoreite) or hydrous (for trachyte) conditions. At low pressure (200 MPa), temperatures below 850 °C, and anhydrous conditions, the degree of crystallization is extremely high (>90%), and the residual glass obtained from trachyte experiments is characterized by peralkaline and sodic affinity. This finding is consistent with natural eruptive products containing interstitial phonolitic glass within an anorthoclase framework. The shift from trachyte to phonolite is therefore interpreted as the result of open system interaction between trachytic magma and intercumulus phonolitic melt, as well as of dissolution of anorthoclase from a crystal mush.
Chemical and textural relations of britholite- and apatite-group minerals from hydrothermal REE mineralization at the Rodeo de los Molles deposit, Central Argentina
Authors: Lorenz Melanie , Altenberger Uwe , Trumbull Robert B. , Lira Raúl , López de Luchi Mónica , Günter Christina , Eidner Sascha
Published: September 2019

Britholite group minerals (REE,Ca)5[(Si,P)O4]3(OH,F) are widespread rare-earth minerals in alkaline rocks and their associated metasomatic zones, where they usually are minor accessory phases. An exception is the REE deposit Rodeo de los Molles, Central Argentina, where fluorbritholite-(Ce) (FBri) is the main carrier of REE and is closely intergrown with fluorapatite (FAp). These minerals reach an abundance of locally up to 75 modal% (FBri) and 20 modal% (FAp) in the vein mineralizations. The Rodeo de los Molles deposit is hosted by a fenitized monzogranite of the Middle Devonian Las Chacras-Potrerillos batholith. The REE mineralization consists of fluorbritholite-(Ce), britholite-(Ce), fluorapatite, allanite-(Ce), and REE fluorcarbonates, and is associated with hydrothermal fluorite, quartz, albite, zircon, and titanite. The REE assemblage takes two forms: irregular patchy shaped REE-rich composites and discrete cross-cutting veins. The irregular composites are more common, but here fluorbritholite-(Ce) is mostly replaced by REE carbonates. The vein mineralization has more abundant and better-preserved britholite phases.

The majority of britholite grains at Rodeo de los Molles are hydrothermally altered, and alteration is strongly enhanced by metamictization, which is indicated by darkening of the mineral, loss of birefringence, porosity, and volume changes leading to polygonal cracks in and around altered grains. A detailed electron microprobe study of apatite-britholite minerals from Rodeo de los Molles revealed compositional variations in fluorapatite and fluorbritholite-(Ce) consistent with the coupled substitution of REE3+ + Si4+ = Ca2+ + P5+ and a compositional gap of ~4 apfu between the two phases, which we interpret as a miscibility gap. Micrometer-scale intergrowths of fluorapatite in fluorbritholite-(Ce) minerals and vice versa are chemically characterized here for the first time and interpreted as exsolution textures that formed during cooling below the proposed solvus.
Electrical conductivity studies on silica phases and the effects of phase transformation
Authors: Amulele George M. , Lanati Anthony W. , Clark Simon M.
Published: September 2019

Starting with the same sample, the electrical conductivities of quartz and coesite have been measured at pressures of 1, 6, and 8.7 GPa, respectively, over a temperature range of 373–1273 K in a multi-anvil high-pressure system. Results indicate that the electrical conductivity in quartz increases with pressure as well as when the phase change from quartz to coesite occurs, while the activation enthalpy decreases with increasing pressure. Activation enthalpies of 0.89, 0.56, and 0.46 eV, were determined at 1, 6, and 8.7 GPa, respectively, giving an activation volume of –0.052 ± 0.006 cm3/mol. FTIR and composition analysis indicate that the electrical conductivities in silica polymorphs is controlled by substitution of silicon by aluminum with hydrogen charge compensation. Comparing with electrical conductivity measurements in stishovite, reported by Yoshino et al. (2014), our results fall within the aluminum and water content extremes measured in stishovite at 12 GPa. The resulting electrical conductivity model is mapped over the magnetotelluric profile obtained through the tectonically stable Northern Australian Craton. Given their relative abundances, these results imply potentially high electrical conductivities in the crust and mantle from contributions of silica polymorphs.

The main results of this paper are as follows:The electrical conductivity of silica polymorphs is determined by impedance spectroscopy up to 8.7 GPa.The activation enthalpy decreases with increasing pressure indicating a negative activation volume across the silica polymorphs.The electrical conductivity results are consistent with measurements observed in stishovite at 12 GPa.
Anomalous phase ordering of a quenched ferromagnetic superfluid
Authors: Williamson Lewis , Blackie Blair
Published: September 2019

Coarsening dynamics, the canonical theory of phase ordering following
a quench across a symmetry breaking phase transition, is thought to be
driven by the annihilation of topological defects. Here we show that
this understanding is incomplete. We simulate the dynamics of an
isolated spin-1 condensate quenched into the easy-plane ferromagnetic
phase and find that the mutual annihilation of spin vortices does not
take the system to the equilibrium state. A nonequilibrium background of
long wavelength spin waves remain at the Berezinskii-Kosterlitz-Thouless
temperature, an order of magnitude hotter than the equilibrium
temperature. The coarsening continues through a second much slower scale
invariant process with a length scale that grows with time as
t^{1/3}t1/3.
This second regime of coarsening is associated with spin wave energy
transport from low to high wavevectors, bringing about the the eventual
equilibrium state. The transport displays features of a spin wave energy
cascade, providing a potential profitable connection with the emerging
field of spin wave turbulence. Strongly coupling the system to a
reservoir destroys the second regime of coarsening, allowing the system
to thermalise following the annihilation of vortices.
Methodological support for estimating the level of internal communications efficiency at an enterprise
Authors: Demchenko Hanna
Published: September 2019

Systematic analysis of the level of communication efficiency at an enterprise ensures its increased performance. Thus, it helps to establish long-term partnership relations with contact audiences and to form consumer loyalty in the external environment. As for the internal environment of an enterprise, the analysis of communication processes can reveal the “unformalized” relations between management and subordinates, determine the degree of autonomy of the individual units, evaluate the effectiveness of the feedback between the components of the management structure. It thus helps to establish effective communication processes within the enterprise. Therefore, assessing the effectiveness of communication processes at an enterprise is of particular significance. In view of this, the purpose of the article is to develop a methodological support for estimating the level of internal communications efficiency at the enterprise. The system of indicators for the internal communications assessment has been proposed, which includes quantitative and qualitative indicators and makes it possible to comprehensively assess the state and the level of internal communications efficiency. In order to assess the level of internal communications effectiveness, the methodological approach is proposed, which is based on the use of expert methods, taking into account logical rules for constructing functions of each element attribute and the process of internal communications. This methodological approach may be used at the industrial enterprises in order to determine the level of internal communications efficiency at the operating departments or at the enterprise as a whole.
Optical and Radar Data Analysis for Land Use Land Cover Mapping in Peru
Authors: Haack Barry , Mahabir Ron
Published: September 2019

This analysis determined the best individual band and combinations of various numbers of bands for land use land cover mapping for three sites in Peru. The data included Landsat Thematic Mapper (TM) optical data, PALSAR L-band dual-polarized radar, and derived radar texture images. Spectral signatures were first obtained for each site class and separability between classes determined using divergence measures. Results show that the best single band for analysis was a TM band, which was different for each site. For two of the three sites, the second best band was a radar texture image from a large window size. For all sites the best three bands included two TM bands and a radar texture image. The original PALSAR bands were of limited value. Finally upon further analysis it was determined that no more than six bands were needed for viable classification at each study site.
Egyszülős családok és politikák Magyarországon és Európában
Authors: Judit Monostori
Published: September 2019

Az egyszülős családok szegénységi kockázata minden országban lényegesen meghaladja a társadalmi átlagot és a gyermeket nevelő, párkapcsolaton alapuló családok kockázati mutatóját is. Mit tehet ilyenkor az állam? Milyen mértékben tud segíteni ezeknek a családoknak? Milyen mértékben akarja segíteni őket? Tanulmányunkban ezekkel a kérdésekkel foglalkozunk. Rámutatunk arra, hogy az egyszülős családok Európa egyetlen országában sem preferált csoportjai a társadalompolitika különböző területeinek. Ennek részben ideológiai okai vannak, azaz az európai politikák próbálják elkerülni annak a látszatát, hogy támogatják, ha csak egy szülő neveli a gyermekeket. Másrészt erős a visszaélésektől való félelem is, azaz, hogy a gyermeket nevelők ’csak papíron élnek külön’, hogy állami transzferekre tegyenek szert. Magyarországon az elmúlt években lényegesen növekedett a párkapcsolaton alapuló és az egyszülős gyermekes családok szegénységi mutatói közötti távolság. Ennek az az oka, hogy míg az előbbi csoport esetében az állami újraelosztás jelentősen tudta csökkenteni a szegénységnek kitett csoportok arányát, addig az egyszülős családok szegénységi kockázata nem változott. Írásunkban áttekintjük, hogy hogyan járulnak hozzá ehhez a férfiak és a nők munkaerőpiaci helyzetének különbségei, az apaság intézményének alakulása, a gyermekellátórendszer működése és az állami redisztribúció.
Delivering Anger Management Treatment through a Web-Based Intervention Supplemented with Brief Coaching: A Pilot Study (Preprint)
Authors: Mackintosh Margaret-Anne , Greene Carolyn J , Glassman Lisa H , Willis Emy A , Schaper Kim M , Morland Leslie A
Published: September 2019

BACKGROUND

Dysregulated anger as part of posttraumatic stress disorder (PTSD) can disrupt interpersonal functioning and negatively impact mental and physical health. However, many individuals are not able or willing to access clinic-based services. Self-management interventions, such as web-based programs, can reach those who need treatment but are not obtaining care from clinics.

OBJECTIVE

This paper describes a pilot study investigating a self-directed web-based anger management intervention, combined with brief clinician-level support, for veterans.

METHODS

The Anger and Irritability Management Skills (AIMS) course is an eight-session cognitive-behavioral program. This intervention was augmented with weekly phone-based coaching to enhance treatment engagement. Six males living on the Hawaiian Islands enrolled in the study.

RESULTS

Results broadly supported the feasibility, efficacy, and usability of the AIMS intervention with briefing coaching. Four of the six (67%) participants completed the study. Three of these four (75%) demonstrated statistically significant reductions in anger symptoms. AIMS received high usability ratings. Participants reported phone coaching to be helpful in completing the intervention and learning anger management skills. Individuals who terminated treatment early had higher anger and mental health scores at baseline compared to those who completed the intervention.

CONCLUSIONS

The AIMS intervention with brief clinician-level coaching performed well across several indicators, including feasibility, usability, treatment engagement, and initial efficacy. Results highlight the utility of self-management interventions along the continuum of care.

CLINICALTRIAL

pilot study
Beliefs and Information Seeking in Patients With Cancer in Southwest China: Survey Study (Preprint)
Authors: Xie Juan , Xie Shi , Cheng Ying , He Zhe
Published: September 2019

BACKGROUND

Although previous studies have reported the cancer information-seeking behaviors among patients in high-income countries, the cancer information-seeking practices of patients living in low- and middle-income areas are less known.

OBJECTIVE

This study investigated the beliefs and information-seeking patterns of cancer patients in southwest China.

METHODS

A questionnaire was designed, and data were collected in two hospitals (N=285) in southwest China. Statistical analyses included bivariate analyses and regressions.

RESULTS

Patients’ attitudes towards cancer fatalism were significantly influenced by marital status (P<.001), education (P<.001), and household income (P<.001). Moreover, endorsing fatalistic belief was positively associated with age (r=0.35, P<.001). The regression model showed that younger patients (odds ratio [OR] 0.96, 95% CI 0.93-0.99) and those with higher education (OR 1.75, 95% CI 1.09-2.81) were more likely to seek information. Additionally, patients who were less confident in getting information were more likely to find information (OR 1.70, 95% CI 1.15-2.52), while fatalism belief was not significant in the regression (OR 0.65, 95% CI 0.22-1.95).

CONCLUSIONS

This study explored the information-seeking patterns of cancer patients in southwest China. It was found that many Chinese people endorsed cancer fatalism. These pessimistic beliefs about the potential to prevent and to cure cancer correlate with rather than cause cancer-related information seeking. However, self-efficacy about the confidence in finding needed cancer information was a significant predictor of information-seeking.
Evaluating the Feasibility of Frequent Cognitive Assessment Using the Mezurio Smartphone App: Observational and Interview Study in Adults With Elevated Dementia Risk (Preprint)
Authors: Lancaster Claire , Koychev Ivan , Blane Jasmine , Chinner Amy , Wolters Leona , Hinds Chris
Published: September 2019

BACKGROUND

By enabling frequent, sensitive, and economic remote assessment, smartphones will facilitate the detection of early cognitive decline at scale. Previous studies have sustained participant engagement with remote cognitive assessment over a week; extending this to a period of 1 month clearly provides a greater opportunity for measurement. However, as study durations are increased, the need to understand how participant burden and scientific value might be optimally balanced also increases.

OBJECTIVE

This study explored the little but often approach to assessment employed by the Mezurio app when prompting participants to interact every day for over a month. Specifically, this study aimed to understand whether this extended duration of remote study is feasible, and which factors promote sustained participant engagement over such periods.

METHODS

A total of 35 adults (aged 40-59 years) with no diagnosis of cognitive impairment were prompted to interact with the Mezurio smartphone app platform for up to 36 days, completing short, daily episodic memory tasks in addition to optional executive function and language tests. A subset (n=20) of participants completed semistructured interviews focused on their experience of using the app.

RESULTS

Participants complied with 80% of the daily learning tasks scheduled for subsequent tests of episodic memory, with 88% of participants still actively engaged by the final task. A thematic analysis of the participants’ experiences highlighted schedule flexibility, a clear user interface, and performance feedback as important considerations for engagement with remote digital assessment.

CONCLUSIONS

Despite the extended study duration, participants demonstrated high compliance with the schedule of daily learning tasks and were extremely positive about their experiences. Long durations of remote digital interaction are therefore definitely feasible but only when careful attention is paid to the design of the users’ experience.
Desarrollo de la mujer escritora en Inglaterra, siglos XVIII y XIX: contribución de las bibliotecas circulantes para la inclusión femenina en la economía del libro
Authors: Salomão Amanda Christina , Alentejo Eduardo da Silva
Published: September 2019

Artículo sobre la escritura femenina en el contexto de las bibliotecas circulantes inglesas de finales del siglo XVIII a mediados del XIX. Analiza las condiciones socioeconómicas que fomentaron el desarrollo de la mujer como escritora. En específico, considera la contribución de esas bibliotecas –entendidas como establecimientos dedicados a alquilar libros– en el proceso de expansión de las posibilidades de la inclusión femenina en la economía del libro. Con abordaje cualitativo, adopta la investigación bibliográfica y documental, orientada por los estudios de la bibliografía textual. Se infiere que las posibilidades de participación de las mujeres como autoras aumentaron gracias a las bibliotecas circulantes.
Descripción de un libro del siglo XVI que formó parte del acervo original del Colegio de la Compañía de Jesús de Pátzcuaro
Authors: Aceves Ávila Roberto
Published: September 2019

Artículo que describe un libro del teólogo jesuita español Francisco de Ribera sobre los comentarios a los 12 profetas menores del Antiguo Testamento, impreso en Salamanca, España, en 1587. Es uno de los ejemplares más antiguos perteneciente a la biblioteca del Colegio de la Compañía de Jesús de Pátzcuaro, en Michoacán, y hasta ahora no había sido registrado. Este trabajo se inserta en una investigación más amplia sobre impresos religiosos y cultura escrita en México. La descripción y el análisis de su importancia en el contexto de una biblioteca de la época es una aportación al conocimiento del patrimonio bibliográfico del país y contribuye a la mejor comprensión de la historia cultural mexicana durante el siglo XVI.
Representação, identidade e a emergência de uma nova discursividade política: minorias sexuais e de gênero na série Merlí
Authors: Budag Fernanda Elouise , Scabin Nara Lya Cabral
Published: September 2019

No pano de fundo de nossas discussões, o que nos move é o interesse em investigar as dimensões da potencialidade de geração de reconhecimento, por parte de atores sociais, das representações construídas pela série ficcional Merlí, produção catalã disponível no Brasil desde 2016 via plataforma de streaming Netflix. Olhamos para esse objeto empírico, sobretudo, a partir dos conceitos de análise de discurso (CHARAUDEAU, 2010), visando estudar as  representações sobre gênero e sexualidade presentes na obra. De modo distinto de muitos produtos midiáticos, que por vezes acabam por produzir mais invisibilidades, sustentamos a tese de que Merlí tensiona representações correntes de grupos minoritários, em sintonia com uma discursividade política emergente na contemporaneidade – um “novo imaginário político”, nas palavras de Fraser (2006).
Pengembangan Majalah Biologi Berbasis Al-Qur'an Hadist Pada Mata Pelajaran Biologi Untuk Peserta Didik Kelas X Di Tingkat SMA/MA
Authors: Sri Anggoro Bambang , Bidayati Haka Nukhbatul , Hawani Hawani
Published: September 2019

The problem in this study is that there is no teaching material that is associated with the hadith Qur’an in  the  school  that  has  Islamic  nuances,  the teaching material used more material and a few of picture as help from the materials, study aims develop magazine learning media feasibility, attractiveness  in  the  cognitive  domain  of  student.  This   type   of   research   is   a   development   research  (Research  and  Development),  using  the  development procedure of Borg ang Gall up to step 7, the data obtained will be analyzed with deccriptive percentages and qualitative data. The result of the study showed that the hadist learning media based on the biological magazine of the Qur’an was very suitable to used as ,learning meddia for class X students. This can be seen from the percentage of media expert validation of 82,8%, material expert validation 87,5%, linguits by 83%, and religious experts by 87,5%, teacher responses by 84,56%, and students’ responses by 81,8%. From the Reselt of study it can be concluded that the biological learning media based on the hadith Qur’an with viral material is very feasible to be used as medic learning in SMA/MA

Key Words: Biology, Bio Magazine, Hadith Qur'an

Abstrak : Masalah dalam penelitian ini adalah belum adanya bahan ajar yang berkaitan dengan Al-Qur’an hadist disekolah yang buansa islam. Bahan ajar yang digunakan lebih banyak menyajikan berupa materi dan minim gambar sebagai pembantu  dari materi tersebut. Penelitian bertujuan untuk mengembangkan media pembelajaran majalah, kelayakan, kemenarikan dalam ranah kognitif peserta didik Jenis penelitian ini merupakan penelitian pengembangan (Reseaarch and Developmwnt) dengan menggunakan prosedur pengembangan Borg and Gall sampai dengan langkah 7, data yang diperoleh akan dianalisis dengan deksriptif persentase dan data kualitatif. Hasil penelitian menunjukkan bahwa media pembelajaran majalah biologi berbasis Alquran hadist sangat layak digunakan media pembelajaran peerta didik kelas X. Hal ini dapat dilihat dari hasil persentase validasi ahli media sebesar 82,8%, validasi ahli materi sebesar 90,45%, ahli bahasa diperoleh 83%, ahli agama sebesar 87,5%, respon pendidik sebesar 84,56%, meunjukkan kriteria sangat menarik, dan respn peserta didik sebesar 81,8%. Dari hasil penelitian dapat disimpulkan bahwa media pembelajarn majalah biologi berbasis Alquran hadist dengan materi virus sangat layak digunakan sebagai media pembelajaran di SMA/MA di Lampung.

Kata kunci : Al-Qur’an Hadist, Biologi, Majalah Bio
PERCEPTIONS OF SERVICE-ORIENTATION AND TRUST OF TAX OFFICERS BETWEEN MILLENIALS, X, AND BABY BOOMERS
Authors: Tjondro Elisa , Santosa Kezia Gabriel , Prayitno Nathasa
Published: September 2019

The purpose of this study is to examine differences in perceptions of generations related to service-orientation and trust to tax officers. Changes traditional paradigm of the relationship between tax officers and taxpayers from “cops and robbers” to "clients" cause the research in perception of service-orientation and trust to tax officers to be necessary in order to improve voluntary tax compliance. This study also explains perceptions of tax fairness in three perspectives which are vertical equity, horizontal equity, exchange equity. The survey was conducted in 2018 with 165 self-employment individual taxpayers consisting of three generations, Millennials, X, and Baby Boomers from two types of work, retail/production and services business. This study uses quota sampling to collect respondents and use ANOVA statistical tests. The results of the study indicate differences in perceptions regarding service-orientation between generations. However, there are no differences in perception related trust to tax officers between generations. This research also found that Millenials, X, and Baby Boomer have different perceptions of vertical equity, horizontal equity, and exchange equity
INVESTOR BEHAVIOR IN DETERMINING INVESTMENT ON REAL ASSET
Authors: Yuniningsih Yuniningsih , Taufiq Muhamad
Published: September 2019

Behavior in determining investment is influenced by factors from the fundamental side or individual psychology. This study aims to determine how psychological factors influence investor behavior in determining future investments. This research is a field experimental study using questionnaire data. The variables used in investment decision making include loss aversion, regret aversion and illusion of control bias with 15 total indicators. The sample is an investor in the real asset field and the data is processed using the Structural Equation Model (SEM) with the AMOS program. The results showed that psychological factors both loss aversion and illusion of control bias had a significant effect on investment decisions in a positive direction. While regret aversion has a significant effect with negative direction with investment decisions. Novelty in this study, that psychological factors in behavior finance not only affect securities investors but also real asset investors.
Análise do saldo do Regime Geral da Previdência Social no Brasil: afinal, existe déficit ou superávit?
Authors: Quintanilha Dayane Ferreira , Profeta Graciela Aparecida , Mérida Simone Manhães Arêas
Published: September 2019

O debate acerca das políticas públicas de assistência social no Brasil tem-se tornado cada vez maisconstante e intenso. Entre os principais pontos dessa discussão está a previdência social, tema constantementedebatido, principalmente a partir da Constituição Federal de 1988. Apesar da importância do sistema de proteçãosocial para a subsistência de muitos cidadãos, e consequentemente, para a economia brasileira, há divergênciassobre o assunto, principalmente no meio acadêmico, tendo em vista que existem basicamente dois grupos depesquisadores com visões contrárias quanto ao saldo do RGPS, ou seja, ao fato de este possuir superávit oudéficit. Este artigo objetivou expor e elucidar os argumentos levantados por ambos os grupos que norteiam taldiscussão, bem como verificar o saldo do RGPS, com base na Constituição Federal de 1988 e na Lei do Plano deCusteio da Previdência Social. Para alcançar os objetivos propostos, realizou-se uma revisão de literatura, bemcomo a apuração do saldo do fluxo de caixa do RGPS, no período de 2002 a 2014. Os resultados indicaram quea previdência social brasileira foi superavitária no período analisado, com uma média positiva de 27 bilhões dereais. A conclusão alcançada é que, atendendo ao disposto no artigo 195 da CF de 1988 e na Lei do Plano deCusteio da Seguridade Social, o saldo é superavitário e, a depender da metodologia de apuração do RGPS, estepode ser deficitário ou superavitário e, assim, influenciar o comportamento dos cidadãos e do Governo.
Revisitando o modelo processual de análise de políticas públicas com base nas relações entre Estado e Sociedade
Authors: Ferreira Patrícia Aparecida , Alencar Edgard , Pereira José Roberto
Published: September 2019

O trabalho procura discorrer sobre alguns aspectos transversais na análise de política pública sob aperspectiva do modelo processual (ciclo de política pública), tais como: instituições, fragmentação,descentralização, participação, saber técnico e saber local. O modelo processual é enfocado não apenas comouma sistematização de fases administrativas (formulação, implementação e avaliação), mas considerados aspectosde diferentes naturezas. Portanto, este trabalho propõe que o modelo processual seja compreendido como umaconstrução social, na qual as políticas emergem de um processo interativo entre Estado e Sociedade. Além disso,rompe-se com a ideia de que a análise de políticas públicas abrange apenas preceitos da perspectivatecnoburocrática, mas, sobretudo, instiga iniciativas de formação da esfera pública e emancipação social, servindocomo referência para a gestão social de políticas públicas.
Enraizamento social do mercado no Brasil: uma abordagem a partir da economia política institucionalista e dos intérpretes do Brasil
Authors: Aguilar Filho Hélio Afonso de
Published: September 2019

O presente trabalho aborda uma categoria central na análise econômica, o mercado. Assume, com baseno referencial teórico da economia política institucionalista, dois pressupostos: 1º) que os mercados sãoinstituições enraizadas histórica e socialmente e 2º) que a noção de mercado livre, tão importante para oliberalismo ortodoxo, é insustentável, dado que a abrangência do mercado é também uma construção social quemuda conforme a época e a interação das forças políticas. Uma análise mais específica do enraizamento dessainstituição e das suas determinações políticas será feita observando-se as formulações dos chamados Intérpretesdo Brasil. Com essa literatura buscar-se-á mostrar que no Brasil, os mercados se desenvolveram apropriados porgrupos de interesses, acarretando distorções em seus mecanismos de incentivos. Várias razões são apresentadaspara essa apropriação, incluindo desde a influência do patrimonialismo herdado de Portugal até a dependênciaeconômica do país. O presente trabalho, contudo, segue a interpretação mais recente que identifica a estruturaextremamente desigual e excludente da distribuição de riqueza como a causa das distorções no funcionamentodo mercado.
PREDICTION OF NUSSELT NUMBER OF RECTANGULAR FINS USING ARTIFICIAL NEURAL NETWORK MODEL
Authors: AYLİ Ece
Published: September 2019

Pasif ısı transferi iyileştirme metodlarında ısı transferi kat sayısı ve Nusselt sayısını maximize ederken, basınç düşümünü minimize eden yaklaşımı tespit edebilmek için bir çok parametrenin optimizasyonunun yapılması gerekmektedir. Bu sebepten ötürü, deneysel ve sayısal çalışmalara bağlı olarak ampirik korelasyonlar elde edilmektedir. Bu çalışmada dikdörtgensel finlerin ısı transferi davranışı deneysel ve yapay sinir ağları metodları ile ortaya konmuştur. Yapay sinir ağları metodolojisi ile elde edilen sonuçlar korelasyon ile kıyaslanmıştır.  Ayrıca, tanımlanan problem için yapay sinir ağı uygulamasında farklı eğitim algoritmalarının ve katman sayısının sonuçlar üzerindeki etkisi araştırılmıştır. Elde edilen sonuçlara göre YSA yöntemi, korelasyon yönteminden daha hızlı ve daha doğru sonuç vermektedir. Diğer yandan YSA yaklaşımının doğruluğunun arttırılması için uygun eğitim algoritmasının seçimi, uygun katman sayısının tespiti yani uygun mimarinin elde edilmesi önem arz etmektedir.  Tanımlanan bu problem için, 10-5-1 ağına sahip Bayesian Regularization algoritması %7.6 ortalama yüzde hata ve 0.029 RMSE ile iyi senaryo olarak belirlenmiştir. Maximum ortalama hata %56.3 ile  Levenberg- Marquardt algoritmasında 10-12-1 ağı ile elde edilmiştir.
The Evolution of Cathedral Planning on the Baltic Sea Southern Cast during the 13th – 14th Centuries in Context of European Building Traditions
Authors: Ozola Silvija
Published: September 2019

In Rome, Emperor Constantin I started to build the most ancient cathedral – the five-nave
Archbasilica of St. John in Lateran, but the Lateran Palace was given as a present to Bishop of Rome for his residence. Perimeter building blocks set up the building complex. In Europe, during the 6th–9th centuries numerous rulers proclaimed Christianity as the only religion in the country. The Church strengthened its impact on the society and governmental administration. In Rome, like in Jerusalem, a religious centre was created,
but in the middle of the 8th century, a city-state Vatican was founded, and on one of hills, the Pope’s residence was placed. Christians organized structures governed by Bishops and founded Catholic church-states – bishoprics. In the late 12th century, subjugation of the lands populated by the Balts and the Finno-Ugric tribes began. Bishoprics and cult centres were founded, and residences for Bishops and Canonical Chapters were envisaged. The bishopric main building was the cathedral. In Europe during lots of centuries evolution of the cathedral building-type happened. In the Balts and Finno-Ugric lands cathedrals were affected by local building traditions. The origins of the Riga Cathedral (Latvian: Rīgas Doms) can be found in 1201–1202, when the bishopric centre
from Üxküll was moved to the newly-founded Riga, where the Bishop’s residence was built on a geopolitically and strategically convenient place. The most important centres to look for inspirations were Braunschweig, Westfalen, Köln, Lübeck, Ratzeburg, Bremen, Hamburg. Research problem: interpretations of sacral building typology and terminology application cause difficulties in the research of historical building plans. Research topicality: evolution of the cathedral building-type and impact of cathedral building complexes on formation and planning of medieval urban structures during the 13th and
14th century. Goal of the research: analyse planning of historical structure in urban centres of bishoprics to determine significance of cathedrals as architectural dominances in spatial composition of towns. Research novelty: this research is based on Latvian historians and archaeologists’ former studies. Nevertheless, opportunities provided by the analysis of urban planning and cartographic materials have been used, and created building due to local construction traditions has been assessed in the European context. Results: study of architecture, layout formation and structure of cathedrals on the southern Baltic Seacoast lands during the 13th and 14th centuries. Main methods applied: this study is based on research and analysis of archive documents, projects and cartographic materials of urban planning, as well as study of published literature and inspection of buildings in nature.
Comparison of mixing performances of T, Y and arrow-shaped micromixers using Villermaux-Dushman protocol at low Reynolds number
Authors: Okwundu Onyeka , Fuseini Mohammed , El-Shazly Ahmed , Elkady Marwa
Published: September 2019

Mixing performance is commonly assessed using the Villermaux? ?Dushman protocol. Mixing in passive mixers may need to be at very low Reynolds number (Re). This study is aimed at comparing the mixing performances of T, Y and arrow-shaped micromixers using the Villermaux?Dushman protocol at Re < 100. The mixing performance test was run at flow rates of 500 to 1 mL h-1 with the pressure drop measurement. Based on UV absorbance values and experimental mixing times of mixed fluids from the three micromixers, the order of mixing performance at Re > 26.5 was Y < T < arrow-shaped micromixers. At lower Re values, the order of performance based on the absorbance and the experimental mixing times, became inconsistent. However, the comparison of mixing performance based on predicted mixing time gave consistent order of performance at all Re values. The instability in UV absorbance of mixed reagents in Villermaux?Dushman protocol was noted as the major cause of the reported inconsistency at very low Re. The inadequacy of Villermaux? ?Dushman protocol at low Re was verified via facile solvent extraction test. A more reliable technique should be used to assess the mixing performance of micromixers at very low Re and on-line UV measurement should be adopted for the Villermaux?Dushman experiment.
Trabajo social y el enfoque sostenible 2030
Authors: Álvarez Santana Carmita Leonor
Published: September 2019

Recepción: 22/ 07/ 2019

Aceptación: 12/ 08/ 2019

Publicación: 07/ 09/2019

La actual investigación tiene como propósito la revisión del trabajo social y el enfoque sostenible, esto permite conocer la tendencia del trabajo social como factor cooperativo en la consolidación de los objetivos de desarrollo sostenible, siendo pertinente diseñar políticas públicas que permitan promover acciones concretas en tal fin, para tal fin se ha empleado la revisión documental de 25 referencias bibliográficas, siendo el 99% pertenecientes a trabajos publicados en revistas arbitradas indizadas, para lo cual se aplicó la técnica de análisis de contenido para  analizar los significados presentes en los documentos. Entre los principales aportes, se tiene que el trabajo social debe redescubrir su esencia desde la visión sujeto – sujeto como medio de contribución eficaz de cara al   2030, siendo que la formación de los nuevos profesionales de trabajo social, debe contar con las aristas necesarias para una formación compleja que les permita tener una visión global de ciudadanía planetaria.

 