bluuebunny/crossref_metadata_2025 huggingface dataset:
348. IDENTIFYING NOVEL MOLECULAR SUBTYPES OF ESOPHAGEAL ADENOCARCINOMA USING LASER CAPTURE MICRODISSECTED RNA-SEQ SAMPLES
Authors: Wilson Gavin , Cotton James , Allison Frances , Bach Yvonne , Allen Jonathan , Darling Gail , Elimova Elena , Kalimuthu Sangeetha , Yeung Jonathan
Published: August 2023

Background

Treatment options for esophageal adenocarcinoma (EAC) are limited by a lack of disease stratification methods. In other cancers, gene expression profiling has been successfully used to identify prognostically-relevant and treatment-susceptible molecular subtypes. Previous efforts to subtype EAC have been hindered by low biopsy and resection tumour cellularity. We hypothesize that laser-capture microdissection (LCM) tumour cell enrichment will permit the classification EAC tumours into multiple molecular subtypes that will be important for future therapeutic strategies.

Methods

Treatment naïve patient samples (N = 52) were collected from primary biopsies (N = 37), resections (N = 10) and metastatic biopsies (N = 5). Samples were laser-capture microdissected to enrich tumour cells followed by total RNA-seq. Gene expression was quantified using salmon and non-negative matrix factorization with 10 components was used to identify gene expression programs. The components identified were validated on a publicly available normal tissue cohort (N = 13 esophagus, gastric, intestinal, Barrett’s samples) and the TCGA EAC cohort (N = 80). We applied NMF with 4 components to the normal tissue (K = cohort) to identify normal tissue gene signatures to validate our RNA-seq data.

Results

We verified that our RNA-seq samples were depleted for normal tissue using the four NMF signatures from normal tissue cohort and, as expected, our samples were depleted for gene expression from the gastric and esophagus tissues compared to TCGA. Next, we explored the gene expression programs from our tumour samples and identified seven tumour-intrinsic components and three tumour microenvironmental components. The top 50 genes from each tumour intrinsic components were used with consensus cluster plus to identify K = 6 subtypes (Figure 1). Interestingly, two of these subtypes would be difficult to separate from normal tissue contamination without the use of LCM.

Conclusion

We have successfully used LCM to deplete normal tissue gene expression from our esophageal adenocarcinoma cohort and identified six molecular subtypes. We are currently evaluating the treatment and clinical implications of these subtypes and aiming to accumulate an additional (N = 50) EAC RNA-seq samples.
370. TRANSMEDIASTINAL ESOPHAGECTOMY IS USEFUL FOR ESOPHAGOGASTRIC JUNCTION CANCER
Authors: Miwa Yoshiyuki , Yagi Koichi , Atsumi Shinichiro , Okamoto Asami , Oya Syuichiro , Urabe Masayuki , Sakamoto Kei , Okumura Yasuhiro , Yajima Sho , Sachiyo Nomura , Yasuyuki Seto
Published: August 2023

Background

The extent of surgical resection and lymph node dissection in esophagogastric junction cancer depends on the localization of the tumor center and the length of esophageal invasion. We developed Robot assisted-transmediastinal esophagectomy (TME) and have been applied for thoracic esophageal cancer. Since 2018, we also applied TME for esophagogastric junction (EGJ) cancer with esophageal involvement according to our determined indications, and examined its safety and usefulness.

Methods

Our indication of esophagetomy for EGJ cancer is, i) squamous cell carcinoma, ii) differentiated adenocarcinoma with≧3 cm esophageal involvement, iii) poorly differentiated with≧2 cm. Since 2018, we applied TME for all of these cases.

Our operation procedure is following; upper thoracic paraesophageal LNs and recurrent nerve LNs are dissected by left-side cervical mediastinoscopic approach. Lower mediastinal LN is dissected by laparoscopic approach. Subcarinal LNs and main bronchus LNs are dissected by transhiatal robotic approach. When robot is not used, these LNs are dissected mediastionscopically. Reconstruction is done by gastric tube through posterior mediastinal route.

Results

Between January 2018 and March 2023, 36 patients was performed TME for EGJ cancer. In these, robot was used in 24 patients. Median operation time and amount of blood loss were 429 minutes and 170 mL. Pathological metastasis of thoracic paratracheal LNs; right recurrent nerve LNs, left recurrent nerve LNs and tracheobronchial LNs was detected in 2(5.5%), 1(2.7%) and 1(2.7%) patients, respectively. Anastomotic leakage was occurred in 2(5.5%) patients, but recovered conservatively. Recurrent laryngeal nerve (RLN) palsy severe more than Clavien-Dindo (CD) grade III was not occurred. Postoperative complications≧C-D IIIb was occurred in 1(2.7%) patient.

Conclusion

TME for EGJ cancer seems to be safe, especially can avoid intra-mediastinal anastomosis and severe complication associated with leakage. It might be more widely accepted when RLN palsy could be reduced. Recuurent nerve LNs dissection is main cause of RLN palsy, and not recommended in the algorism of LN dissection for EGJ cancer because the frequency of metastasis is low, so TME without recurrent nerve LNs dissection could be the option for EGJ cancer.
418. A TALE OF SIXTEEN ESOPHAGEAL DUPLICATION CYSTS AND ITS MANAGEMENT STRATEGIES
Authors: Jethani Manish M , Mistry Rajesh
Published: August 2023

Background

Esophageal duplication cysts are rare entities with a spectrum of clinical presentation. Adults are usually asymptomatic. Surgical management is preferred. We present our experience of management of 16 esophageal duplication cysts.

Methods

A retrospective cohort analysis of all esophageal duplication cyst patients was performed at our centre from January 2012 to December 2022. Variables collected include patient demographics, operative techniques, morbidity and mortality. Study data was collected using electronic medical records at our centre and follow-up data was taken physically or telephonically. A total of 16 patients of esophageal duplication cyst were identified, out of which 81.25% (13) underwent surgical excision, 6.25% (1) underwent endoscopic aspiration and 12.5% (2) were conserved with expectant management due to co-morbidities.

Results

Out of 16 patients, 50% (8) were in the lower esophagus, 37.5% (6) were in mid third esophagus and 12.5% (2) were in upper esophagus. The patient population was composed of 75% (12) males and 25% (4) females, and mean age was 47.5 years (27–76). 81.25% (13) patients were symptomatic; common symptoms included chest pain/discomfort, breathlessness, and coughing. The mean size of cyst was 6.4 cm (range: 3-10 cm). 81.25% (13) patients underwent surgery out of which 62.5% (10) underwent VATS/Robotic and 18.75% (3) underwent thoracotomy. The mean hospital stay was 4 days (range: 2–10 days). Two (15.4%) patients developed Clavein-Dindo grade III complication, for which pigtail insertion was done. The most common histopathology found was ciliated columnar epithelium in 61.5% (8) patients.

Conclusion

Esophageal duplication cysts remain rare in adults and are frequently located in the distal esophagus. Various surgical techniques may successfully be employed in the treatment of this pathology. Minimally invasive procedures have a shorter hospital stay.
427. CAN WE OPTIMIZE THE RECOMMENDATIONS FOR FOLLOW-UP OF BARRETT’S ESOPHAGUS THROUGH CRITICAL ANALYSIS OF RISK FACTORS IN A SPECIFIC POPULATION?
Authors: Szachnowicz Sergio , Gallon Eduardo , Duarte Andre Fonseca , Lopes Letícia Nobre , Cirlinas Alexandra Messa , Marques Sergio Barbosa , Moura Eduardo H G , Sallum Rubens A A , Cecconello Ivan
Published: August 2023

Introduction

Barrett’s esophagus (BE) affects approximately 3 million people in Brazil with its incidence has been increasing in recent years. In this pathology, the genetically unstable metaplastic epithelium leads to risks of progression to dysplasia and esophageal adenocarcinoma (EAC). In a scenario where most EACs arise in the presence of BE, it is necessary to study the epidemiological risk factors associated with this evolution to implement optimized surveillance recommendations.

Objective

Evaluate the epidemiological risk factors involved in the development of dysplasia and adenocarcinoma from BE in a specific population and propose an appropriate suggestion on how to carry out the follow-up according to these factors.

Methodology

A retrospective cross-sectional study was conducted in a tertiary center with patients with BE followed in this center. Patients with BE who presented adenocarcinoma and/or dysplasia were compared to those who did not, considering the variables gender, age, smoking, BMI, ethnicity, and extent of Barrett’s. Logistic regression was performed to measure the odds ratio (OR) between risk factors for the outcome of adenocarcinoma and the outcome of dysplasia. Finally, the presence of proven epidemiological risk factors in this population was correlated with the time of development of EAC from BE.

Results

There was a statistically significant difference between smoking, race, gender, extent of Barrett’s, and age among patients that presented adenocarcinoma and not. Smokers and ex-smokers had a 4.309 times higher risk of developing adenocarcinoma, and the extent of Barrett’s increased this risk by 1.193 times per centimeter. Among the group that presented dysplasia compared to the group that did not, smoking, the extent of Barrett’s, and age were statistically significant, with the extent of Barrett’s increasing the risk of developing dysplasia by 1.128 times per centimeter and age increased the risk of this outcome by 1.023 per year. Patients without risk factors did not develop EAC in less than 12 months, even if they had dysplasia before.

Conclusion

The study confirmed a higher risk of developing dysplasia and adenocarcinoma in specific epidemiological groups, which can redirect follow-up in patients with BE in a more cost-effective manner.
439. ACUTE GASTRIC VOLVULUS—LATE OCCURRENCE AFTER HIATAL HERNIA REPAIR WITH MESH
Authors: Brandalise Andre , Lorenzetti Claudia , Coelho-Neto João
Published: August 2023

Video presentation of acute gastric volvulus in one patient with previous history of a giant recurrent hiatal hernia, corrected with synthetic absorbable mesh one year prior to the event.

The video contains the first surgery, follow-up studies, the intra operative findings (mesh status) and resolution. It raises the question whether, in extremely large hiatal hernias, specially recurred ones, adjuvant techniques should be associated.

https://www.dropbox.com/s/tkj2vt35cd3pn91/Acute%20Gastric%20Volvulus.mov?dl=0.
462. MAJOR PATHOLOGIC RESPONSE IN ESOPHAGEAL ADENOCARCINOMA: SHOULD WE ADOPT A NEW PARADIGM IN DEFINING RESPONSE TO TREATMENTS?
Authors: Sciuto Maria Elisa , Capovilla Giovanni , Scarton Alessia , Tagkalos Evangelos , Uzun Eren , Moletta Lucia , Hadzijusufovic Edin , Provenzano Luca , Salvador Renato , Pierobon Elisa Sefora , Zanchettin Gianpietro , Berlth Felix , Lang Hauke , Grimminger Peter P , Valmasoni Michele
Published: August 2023

Background

Incidence of adenocarcinoma (ADC) of the esophagus is arising in Western countries and it is still burdened by a significant mortality. A complete primary tumor regression after neoadjuvant treatment is associated with improved long-term survival, however this favorable response is rarely achieved. The primary endpoint of this study was to determine whether the survival benefit associated with a complete tumor regression could be achieved also with a major, albeit subtotal, tumor response.

Methods

We evaluated all consecutive patients who underwent esophagectomy for cancer at 2 high-volume centers. Inclusion criteria were histologically confirmed ADC involving the thoracic esophagus or Siewert I and II cancers, treated by neoadjuvant chemotherapy (CT) or chemoradiotherapy (CRT) and surgery. Pathological tumor response was quantified using the Mandard score. Kaplan-Maier plots were used to estimate overall survival (OS) according to the TRG.

Results

Overall, 424 patients were recruited in the study period, 236 received CT and 188 CRT. The median follow-up time was 55 months. TRG 1 and 2 showed comparable OS curves both in the CT group (p = 0.76) and in the CRT group (p = 0.82) (Figure 1). TRG 1–2 were associated with a significantly improved OS compared to TRG 3–5 after CT (p = 0.004) and CRT (p = 0.0003). The trend was confirmed in the whole cohort, with TRG 1 and 2 patients showing comparable 5-years OS proportions (70% vs. 65%, p = 0.52) and a significantly improved survival compared to TRG 3–5 (p < 0.0001).

Conclusion

Tumor regression after neoadjuvant treatment is significantly associated with long term survival irrespective of the adopted regimen. The long-term survival was comparable between TRG 1 and TRG 2 patients after CT and CRT and in the overall population. This finding allowed us to define the criterion of major tumor response, which includes both TRG 1 and 2 patients, potentially creating a homogeneous and larger subgroup of subjects to be evaluated in future clinical trials.
463. THE IMPACT OF PATHOLOGICAL TUMOR RESPONSE FOLLOWING NEOADJUVANT CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR ESOPHAGEAL ADENOCARCINOMA. A RETROSPECTIVE MULTICENTER COHORT STUDY
Authors: Scarton Alessia , Capovilla Giovanni , Tagkalos Evangelos , Uzun Eren , Moletta Lucia , Hadzijusufovic Edin , Provenzano Luca , Salvador Renato , Pierobon Elisa Sefora , Zanchettin Gianpietro , Berlth Felix , Grimminger Peter P , Valmasoni Michele
Published: August 2023

Background

Two multimodal strategies are available for the treatment of esophageal cancer: neoadjuvant chemotherapy (CT) and chemoradiotherapy (CTRT). The higher rate of pathological complete response (pCR) after CTRT is an argument to support this treatment. However, previous studies have failed to demonstrate a survival benefit of CTRT for adenocarcinoma (ADC) and the correlation between pathological tumor response (pTR) and survival is unclear.

Methods

This multicenter retrospective cohort study included data from 2 high-volume centers. Only patients with ADC who underwent CT or CTRT and surgery between 2012 and 2019 were included. The correlation between pTR and survival after both treatments was evaluated using Kaplan–Meier analysis. The 5-year overall (OS) and disease-free survivals (DFS) of patients showing pCR after the 2 treatments were compared. pTR was assessed using the Mandard tumor regression grade (TRG).

Results

Overall, 424 patients were included, 236 received CT and 188 CTRT. The incidence of pCR was 12.7% in the CT group and 26.1% after CTRT (p = 0.0005). At 5-years the OS rate after CT was 85.6% for TRG1 patients, 75.5% for TRG2, 57% for TRG3 and 42% for TRG4–5 (p = 0.004). After CTRT it was 72.8% for TRG1, 60.8% for TRG2, 39% for TRG3 and 27% for TRG4–5 (p = 0.0003) (figure 1). The OS of patients with pCR was not significantly different after CT and CTRT (p = 0.65). The 5-years DFS of pCR patients was higher in the CT group (86% vs. 70%, p = 0.05).

Conclusion

Despite a lower rate of pCR, both OS and, especially, DFS of pCR patients were improved after CT compared to CTRT. TRG showed to be significantly associated with survival in both treatment groups. The effectiveness of long-term disease control after CT and CTRT should be further analyzed in ADC.
471. MINIMALLY INVASIVE ESOPHAGECTOMY WITH RESECTION OF THE DESCENDING AORTA DUE TO SUSPECTED TUMOR INFILTRATION
Authors: Menéndez Miriam , Bruna Marcos , Vaqué Javier , Del Olmo Nuria García , Navarro Fernando Mingol , Nieto Marta
Published: August 2023

Background

Classically, esophageal neoplasms have had a poor survival, considering those T4b tumors that infiltrate the aorta, airways or vertebrae to be unresectable despite not having distant disease. With the advancement of surgical techniques, the improvement of neoadjuvant/adjuvant systemic treatments and the multidisciplinary approach to this pathology, these barriers of unresectability are gradually being broken.

Methods

This is a 68-year-old patient, a 1-pack-a-day smoker, who presented squamous cell carcinoma 30 cm from the dental arch treated with chemoradiotherapy according to the CROSS scheme. After surgery at another center, there is suspicion of infiltration of the descending aorta, for which he was referred to our center.

The case is discussed in a multidisciplinary committee and a decision is made to place TEVAR in the first stage and surgical resection of the lesion in a second stage.

Results

The patient underwent surgery performing a three-stage esophagectomy (McKeown) using prone thoracoscopy without selective intubation, through which a regulated esophagectomy was performed with total lymphadenectomy and en bloc resection along with the anterior wall of the descending aorta where there was suspicion of tumor infiltration, exposing the aortic prosthesis (Photo 2). The prosthesis is covered to isolate it from possible sources of infection with a patch of pericardium fixed with loose sutures to the aortic wall and biological glue. It was reconstructed using a mediastinal gastroplasty with cervical circular mechanical anastomosis. Postoperative period marked by cervical leakage that was resolved by conservative treatment.

Conclusion

Resection using a minimally invasive approach of an aortic patch in cases of suspected tumor infiltration in esophageal neoplasms without systemic disease may be a safe therapeutic option as long as it is performed in centers specialized in complex esophageal resections and with a multidisciplinary team that also involves cardiac surgeons. The oncological prognosis must be evaluated in the long term, but achieving R0 resections should not be worse than in locally advanced resectable tumors.
474. MANOMETRIC IDENTIKIT OF A FUNCTIONING AND EFFECTIVE FUNDOPLICATION IN THE HIGH-RESOLUTION MANOMETRY ERA
Authors: Santangelo Matteo , Capovilla Giovanni , Vittori Arianna , Forattini Francesca , Provenzano Luca , Nicoletti Loredana , Costantini Andrea , Moletta Lucia , Valmasoni Michele , Costantini Mario , Savarino Edoardo Vincenzo , Salvador Renato
Published: August 2023

Background

Assessing patients following Laparoscopic Fundoplication (LF) can be challenging. Functional information provided by pathophysiological testing—which can shed light on the cause of recurrent symptoms—could be key to clinical decision making. The value of performing High-Resolution Manometry (HRM) after LF is still unclear and debated. We sought to establish the HRM parameters indicative of a functioning fundoplication, and whether HRM could distinguish it from a tight or defective one.

Methods

We studied patients with gastroesophageal reflux disease (GERD) who underwent laparoscopic Nissen (LN) or Toupet (LT) fundoplication between 2010–2022. HRM and pH monitoring were performed before and 6 months after surgery. LF failure was defined as GerdQ score ≥ 8 and abnormal 24 h-pH study or just abnormal 24 h-pH study. The study population was divided into 5 groups: LN and LT patients with normal pH monitoring (LNpH- and LTpH-, respectively); LN and LT patients with pathological pH monitoring (LNpH+ and LTpH+ groups, respectively); and patients with postoperative severe dysphagia (Dysphagia group). The novel Hiatal Morphology (HM) classification was applied, envisaging 3 subtypes: HM1 (normal morphology); HM2 (intrathoracic fundoplication); and HM3 (slipped fundoplication).

Results

We recruited 132 patients: 46 in the LNpH- group, 51 in the LTpH- group, 15 in the LNpH+ group, 7 in the LTpH+ group, and 5 in the Dysphagia group (Figure 1). Eight patients with GerdQ score ≥ 8 and normal 24 h-pH findings were excluded. At univariate analysis, postoperative lower esophageal sphincter (LES) basal pressure (p = 0.011), total and abdominal LES length (p = 0.014, p < 0.001) were correlated with LF failure. At multivariate analysis, postoperative abdominal LES length (p = 0.001) and HM2 (p < 0.001) were independently associated with surgical failure. Integrated relaxation pressure (IRP) was significantly higher in the Dysphagia group than in the LNpH- group.

Conclusion

This study generated reference HRM values for an effective LF and confirms that using HRM to assess the abdominal portion of the neo-sphincter and abnormal hiatal morphology (HM2) improves the clinical assessment of recurrent symptoms. HRM can distinguish patients with a well-functioning wrap from those developing recurrent GERD due to an ineffective wrap. Postoperative IRP also correlated significantly with the onset of dysphagia after surgery.
481. ROBOTIC THORACIC DISSECTION IN DISTAL ESOPHAGEAL CANCER TREATMENT
Authors: Bianchi Edno Tales , Azevedo Beatriz , Namur Guilhemer , Kruger Jaime
Published: August 2023

We show a robotic dissection with hook with lymphadenectomy and ressection en bloc of a distal esophageal tumor https://drive.google.com/file/d/1qnVnH3DTTv-uqnJRV3337sITqyZyX25K/view?usp=sharing.
Lifetime healthcare expenditures across socioeconomic groups in Sweden
Authors: Fledsberg Stephanie , Svensson Mikael , Johansson Naimi
Published: August 2023

Background

Individuals of lower socioeconomic status generally have higher healthcare expenditures than individuals of higher socioeconomic status. However, little is known about how expenditures are distributed across socioeconomic groups over a lifetime, once accounting for differences in life expectancy. This study describes how lifetime healthcare expenditures are distributed across age, sex and socioeconomic groups in Sweden while adjusting for differences in life expectancy.

Methods

Healthcare utilization from 2016 were linked to demographic and socioeconomic data for a random sample of individuals aged 20 and above in the four largest Swedish regions (n = 440 659). Mortality data were used to estimate income- and sex-specific survival rates. Expected lifetime healthcare expenditures were estimated by combining survival rates with mean healthcare expenditures over age, by sex, and income quintile.

Results

We find that expected lifetime healthcare expenditures are highest among the first (lowest) income quintile despite their evident lower life expectancy. Expected lifetime expenditures were 17.9% (16.8%) higher in the first income quintile compared to the fifth (highest) quintile for women (men). Individuals in the first income quintile had higher expected lifetime expenditures for all care categories except for primary care.

Conclusion

We conclude that despite a lower life expectancy, the quintile of the lowest socioeconomic status still had higher lifetime healthcare expenditures.
Adams v Lindsell [1818] EWHC KB J59; (1818) 1 B & Ald 681; (1818) 106 ER 250
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Adams v Lindsell (1818) 106 ER 250. The document also includes supporting commentary from author Nicola Jackson.
Dickinson v Dodds (1876) 2 Ch D 463
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Dickinson v Dodds (1876) 2 Ch D 463. The document also includes supporting commentary from author Nicola Jackson.
Balfour v Balfour [1919] 2 KB 571 including commentary on Merritt v Merritt [1970] EWCA Civ 6; [1970] 1 WLR 1211.
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Balfour v Balfour [1919] 2 KB 571. The document also includes supporting commentary from author Nicola Jackson.
Chappell & Co. Ltd v Nestlé Co. Ltd [1960] AC 87
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Chappell & Co. Ltd v Nestlé Co. Ltd [1960] AC 87. The document also includes supporting commentary from author Nicola Jackson.
Williams v Roffey Bros & Nicholls (Contractors) Ltd [1991] 1 QB 1
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Williams v Roffey Bros & Nicholls (Contractors) Ltd [1991] 1 QB 1. The document also includes supporting commentary from author Nicola Jackson.
Krell v Henry [1903] 2 KB 740
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Krell v Henry [1903] 2 KB 740. The document also includes supporting commentary from author Nicola Jackson.
Attorney General v Blake & another [2000] UKHL 45; [2001] 1 AC 268
Authors: Jackson Nicola
Published: August 2023

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Attorney General v Blake & another [2000] UKHL 45; [2001] 1 AC 268. The document also includes supporting commentary from author Nicola Jackson.
Essential Cases: Equity & Trusts
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in McPhail v Doulton, Re Baden’s Deed Trusts (No 1) [1971] AC 424, House of Lords. The document also includes supporting commentary from author Derek Whayman.
Pitt v Holt, Futter v Futter [2013] UKSC 26, Supreme Court
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Pitt v Holt, Futter v Futter [2013] UKSC 26, Supreme Court. The document also includes supporting commentary from author Derek Whayman.
Cowan v Scargill [1985] Ch 270, Chancery Division
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Cowan v Scargill [1985] Ch 270, Chancery Division. The document also includes supporting commentary from author Derek Whayman.
Jones v Kernott [2011] UKSC 53, Supreme Court
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Jones v Kernott [2011] UKSC 53, Supreme Court. The document also includes supporting commentary from author Derek Whayman.
Williams v Central Bank of Nigeria [2014] UKSC 10, Supreme Court
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Williams v Central Bank of Nigeria [2014] UKSC 10, Supreme Court. The document also includes supporting commentary from author Derek Whayman.
Re Montagu’s Settlement Trusts [1987] Ch 264, Chancery Division
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Re Montagu’s Settlement Trusts [1987] Ch 264, Chancery Division. The document also includes supporting commentary from author Derek Whayman.
Armitage v Nurse [1998] Ch 241, Court of Appeal
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Armitage v Nurse [1998] Ch 241, Court of Appeal. The document also includes supporting commentary from author Derek Whayman.
Federal Republic of Brazil v Durant International Corporation [2015] UKPC 35, Privy Council
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Federal Republic of Brazil v Durant International Corporation [2015] UKPC 35, Privy Council. The document also includes supporting commentary from author Derek Whayman.
Co-operative Insurance Society Ltd v Argyll Stores (Holdings) Ltd [1998] AC 1, House of Lords
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Co-operative Insurance Society Ltd v Argyll Stores (Holdings) Ltd [1998] AC 1, House of Lords. The document also includes supporting commentary from author Derek Whayman.
American Cyanamid Co v Ethicon Ltd (No 1) [1975] AC 396, House of Lords
Authors: Whayman Derek
Published: August 2023

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in American Cyanamid Co v Ethicon Ltd (No 1) [1975] AC 396, House of Lords. The document also includes supporting commentary from author Derek Whayman.
Internationale Handelsgesellschaft mbH v Einfuhr- und Vorratsstelle für Getreide und Futtermittel (Case 11/70), EU:C:1970:114, [1970] ECR 1125, 17 December 1970
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Internationale Handelsgesellschaft mbH v Einfuhr- und Vorratsstelle für Getreide und Futtermittel (Case 11/70), EU:C:1970:114, [1970] ECR 1125, 17 December 1970. The document also includes supporting commentary from author Noreen O'Meara.
Foster and others v British Gas plc (Case C-188/89), EU:C:1990:313, [1990] ECR I-3313, 12 July 1990
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Foster and others v British Gas plc (Case C-188/89), EU:C:1990:313, [1990] ECR I-3313, 12 July 1990. The document also includes supporting commentary from author Noreen O'Meara.
Foto-Frost v Hauptzollamt Lübeck-Ost (Case C-314/85), EU:C:1987:452, [1987] ECR 4199, 22 October 1987
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Foto-Frost v Hauptzollamt Lübeck-Ost (Case C-314/85), EU:C:1987:452, [1987] ECR 4199, 22 October 1987. The document also includes supporting commentary from author Noreen O'Meara.
Germany v Parliament and Council (‘Tobacco Advertising I’) (Case C-376/98), EU:C:2000:544, [2000] ECR I-8419, 5 October 2000
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Germany v Parliament and Council (‘Tobacco Advertising I’) (Case C-376/98), EU:C:2000:544, [2000] ECR I-8419, 5 October 2000. The document also includes supporting commentary from author Noreen O'Meara.
Commission v Poland (Case C-619/18), EU:C:2019:531, [2008] ECR I-6351, 24 June 2019
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Commission v Poland (Case C-619/18), EU:C:2019:531, [2008] ECR I-6351, 24 June 2019. The document also includes supporting commentary from author Noreen O'Meara.
Inuit Tapiriit Kanatami and others v European Parliament and Council of the European Union (Cases T-18/10 and C-583/11 P ‘Inuit I’), EU:T:2011:419, 6 September 2011/ EU:C:2013:625, 3 October 2013
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Inuit Tapiriit Kanatami and others v European Parliament and Council of the European Union (Cases T-18/10 and C-583/11 P ‘Inuit I’), EU:T:2011:419, 6 September 2011/ EU:C:2013:625, 3 October 2013. The document also includes supporting commentary from author Noreen O'Meara.
Procureur du Roi v Benoît and Gustave Dassonville (Case 8/74), EU:C:1974:82, [1974] ECR 837, 11 July 1974
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Procureur du Roi v Benoît and Gustave Dassonville (Case 8/74), EU:C:1974:82, [1974] ECR 837, 11 July 1974. The document also includes supporting commentary from author Noreen O'Meara.
Blaise Baheten Metock and others v Minister for Justice, Equality and Law Reform (Case C-127/08), EU:C:2008:449, [2008] ECR I-6241, 25 July 2008
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Blaise Baheten Metock and others v Minister for Justice, Equality and Law Reform (Case C-127/08), EU:C:2008:449, [2008] ECR I-6241, 25 July 2008. The document also includes supporting commentary from author Noreen O'Meara.
Commission v Italy (‘Trailers’) (Case C-110/05), EU:C:2009:66, [2009] ECR I-519, 10 February 2009
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Commission v Italy (‘Trailers’) (Case C-110/05), EU:C:2009:66, [2009] ECR I-519, 10 February 2009. The document also includes supporting commentary from author Noreen O'Meara.
María Martínez Sala v Freistaat Bayern (Case C-85/96), EU:C:1998:217, [1998] ECR I-2691, 12 May 1998
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in María Martínez Sala v Freistaat Bayern (Case C-85/96), EU:C:1998:217, [1998] ECR I-2691, 12 May 1998. The document also includes supporting commentary from author Noreen O'Meara.
Association belge des Consommateurs Test-Achats and others v Council (Case C-236/09), EU:C:2011:100, [2011] ECR I-773, 1 March 2011
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Association belge des Consommateurs Test-Achats and others v Council (Case C-236/09), EU:C:2011:100, [2011] ECR I-773, 1 March 2011. The document also includes supporting commentary from author Noreen O'Meara.
Aranyosi and Căldăraru (Joined cases C-404/15 and C-659/15 PPU), EU:C:2016:198, 5 April 2016
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Aranyosi and Căldăraru (Joined Cases C-404/15 and C-659/15 PPU), EU:C:2016:198, 5 April 2016. The document also includes supporting commentary from author Noreen O'Meara.
R.O. (Case C-327/18 PPU), EU:C:2018:733, 19 September 2018
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R.O. (Case C-327/18 PPU), EU:C:2018:733, 19 September 2018. The document also includes supporting commentary from author Noreen O'Meara.
Wightman and others v Secretary of State for Exiting the European Union (Case C-621/18), EU:C:2018:999, 10 December 2018
Authors: O'Meara Noreen
Published: August 2023

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Wightman and others (Case C-621/18), EU:C:2018:999, 10 December 2018. The document also includes supporting commentary from author Noreen O'Meara.
Bernstein of Leigh v Skyviews & General Ltd [1978] QB 479, High Court (Queen’s Bench Division)
Authors: Nair Aruna
Published: August 2023

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Bernstein of Leigh v Skyviews & General Ltd [1978] QB 479, High Court (Queen’s Bench Division). The document also includes supporting commentary from author Aruna Nair.
Lloyds Bank plc v Rosset [1991] 1 AC 107, House of Lords
Authors: Nair Aruna
Published: August 2023

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Lloyds Bank plc v Rosset [1991] 1 AC 107, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Thorner v Major [2009] UKHL 18, House of Lords
Authors: Nair Aruna
Published: August 2023

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Thorner v Major [2009] UKHL 18, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Burgess v Rawnsley [1975] 3 All ER 142, Court of Appeal
Authors: Nair Aruna
Published: August 2023

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Burgess v Rawnsley [1975] 3 All ER 142, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.
Bagum v Hafiz [2015] EWCA Civ 801, Court of Appeal
Authors: Nair Aruna
Published: August 2023

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Bagum v Hafiz [2015] EWCA Civ 801, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.
Anisminic Ltd v Foreign Compensation Commission [1969] 2 AC 147, House of Lords
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Anisminic Ltd v Foreign Compensation Commission [1969] 2 AC 147, House of Lords. This case note deals with how the House of Lords interpreted an ouster clause, a statutory provision which seeks to prevent judicial supervision of decisions made by subordinate decision-making bodies, and considers the wider constitutional implications of the courts’ approach to ouster clauses. The document also includes supporting commentary and questions from author Thomas Webb.
Dimes v Proprietors of the Grand Junction Canal (1852) III House of Lords Cases (Clark’s) 759, 10 ER 301, House of Lords
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Dimes v Proprietors of the Grand Junction Canal (1852) III House of Lords Cases (Clark’s) 759, 10 ER 301, House of Lords. This case concerns an example of a judge holding a pecuniary interest in a case they were adjudicating upon. There is also wider discussion of the concept of bias. The document also includes supporting commentary and questions from author Thomas Webb.
Ellen Street Estates Ltd v Minister of Health [1934] 1 KB 590, Court of Appeal
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Ellen Street Estates, Limited v Minister of Health [1934] 1 KB 590, Court of Appeal. This case concerned whether provisions enacted by an earlier Westminster parliament could bind the legislative choices of future Westminster parliaments. The arguments of Wade and Jennings over Diceyan and ‘manner and form’ approaches to this issue are discussed. The document also includes supporting commentary and questions from author Thomas Webb.
Porter v Magill [2001] UKHL 67, House of Lords
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Porter v Magill [2001] UKHL 67, House of Lords. This case note considers the introduction of a revised test for bias in public law decision-making. The document also includes supporting commentary and questions from author Thomas Webb.
R v Inspectorate of Pollution, ex parte Greenpeace Ltd (No. 2) [1994] 2 CMLR 548, High Court (Queen’s Bench Division)
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Inspectorate of Pollution, ex parte Greenpeace Ltd (No. 2) [1994] 2 CMLR 548, High Court (Queen’s Bench Division). This case concerned whether organizations could demonstrate a sufficient interest for the purposes of bringing a judicial review on the basis of their expert knowledge and the public interest in bringing an application for review. The document also includes supporting commentary and questions from author Thomas Webb.
R v Panel on Take-overs and Mergers, ex parte Datafin plc [1987] QB 815, Court of Appeal (Civil Division)
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Panel on Take-overs and Mergers, ex parte Datafin plc [1987] QB 815, Court of Appeal (Civil Division). This case examines the characteristics of bodies which can be subject to judicial review, exploring whether bodies which are ostensibly private in nature can be subject to judicial review if the nature or consequences of their functions and decisions are public. The document also includes supporting commentary and questions from author Thomas Webb.
R (on the application of Begum (By her litigation friend, Rahman)) v Headteacher, Governors of Denbigh High School [2006] UKHL 15, House of Lords
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R (on the application of Begum (By her litigation friend, Rahman)) v Headteacher, Governors of Denbigh High School [2006] UKHL 15, House of Lords. This case concerned whether a school unlawfully limited a pupil’s right to manifest her religious beliefs through religious dress. The case note explores how a balance is struck between competing qualified rights, and so also contains discussion of the concept of proportionality. The document also includes supporting commentary and questions from author Thomas Webb.
R (on the application of Cart) v The Upper Tribunal [2011] UKSC 28, Supreme Court
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R (on the application of Cart) v The Upper Tribunal [2011] UKSC 28, Supreme Court. This case examined the circumstances under which the Upper Tribunal would be subject to judicial review. It also considers implications of the government’s proposals in response to the Independent Review of Administrative Law (IRAL) (2021) in the Judicial Review and Courts Bill 2021–22, in terms of the impact on judicial reviews under the process established by Cart. There is also some discussion of ouster clauses. The document also includes supporting commentary and questions from author Thomas Webb.
R (on the application of Daly) v Secretary of State for the Home Department [2001] UKHL 26, House of Lords
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R (on the application of Daly) v Secretary of State for the Home Department [2001] UKHL 26, House of Lords. This case considered whether a blanket policy excluding prisoners from cell searches was a proportionate response that was necessary to achieve the aim of that policy. There is also discussion of whether the common law could provide an alternative system of rights protection to that under the Human Rights Act 1998. The document also includes supporting commentary and questions from author Thomas Webb.
R (on the application of HS2 Action Alliance Ltd) v Secretary of State for Transport [2014] UKSC 3, Supreme Court (also known as R (on the application of Buckinghamshire CC))
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case note summarizes the facts and decision in R (on the application of HS2 Action Alliance Ltd) v Secretary of State for Transport [2014] UKSC 3, Supreme Court (also known as R (on the application of Buckinghamshire CC)). This case note is concerned primarily with the distinction between ordinary and constitutional statutes, and what happens where two constitutional statutes are in conflict. The document also includes supporting commentary and questions from author Thomas Webb.
The UK Withdrawal from the European Union (Legal Continuity) (Scotland) Bill—A Reference by the Attorney General and the Advocate General for Scotland [2018] UKSC 64, Supreme Court (also known as Continuity Bill Reference)
Authors: Webb Thomas E.
Published: August 2023

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in The UK Withdrawal from the European Union (Legal Continuity) (Scotland) Bill—A Reference by the Attorney General and the Advocate General for Scotland [2018] UKSC 64, Supreme Court. This case is concerned with the competencies of the Scottish Parliament, and the nature of devolution in the UK more generally. The document also includes supporting commentary and questions from author Thomas Webb.
Essential Cases: Tort Law
Authors: Purshouse Craig
Published: August 2023

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. Essential Cases provides you with succinct summaries of some of the landmark and most influential cases in tort law. Each summary begins with a review of the main case facts and decision. The summary is then concluded with expert commentary on the case from the author, Craig Purshouse, including his assessment of the wider questions raised by the decision.
Robinson v Chief Constable of West Yorkshire [2018] UKSC 4
Authors: Purshouse Craig
Published: August 2023

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Robinson v Chief Constable of West Yorkshire [2018] UKSC 4. The document also included supporting commentary from author Craig Purshouse.
Frost (or White) v Chief Constable of South Yorkshire Police [1999] 2 AC 455
Authors: Purshouse Craig
Published: August 2023

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Frost (or White) v Chief Constable of South Yorkshire Police [1999] 2 AC 455. The document also included supporting commentary from author Craig Purshouse.
White v Jones [1995] 2 AC 207
Authors: Purshouse Craig
Published: August 2023

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in White v Jones [1995] 2 AC 207. The document also included supporting commentary from author Craig Purshouse.
Barker v Corus UK Ltd [2006] 2 AC 572
Authors: Purshouse Craig
Published: August 2023

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Barker v Corus UK Ltd [2006] 2 AC 572. The document also included supporting commentary from author Craig Purshouse.