bluuebunny/crossref_metadata_2025 huggingface dataset:
Late Development of Sensory Thresholds for Horizontal Relative Disparity in Human Visual Cortex in the Face of Precocial Development of Thresholds for Absolute Disparity
Authors: Norcia Anthony M. , Kaestner Milena , Chen Yulan D. , Clement Caroline S.
Published: January 2025

Immaturities exist at multiple levels of the developing human visual pathway, starting with immaturities in photon efficiency and spatial sampling in the retina and on through immaturities in the early and later stages of cortical processing. Here, we use steady-state visual evoked potentials (SSVEPs) and controlled visual stimuli to determine the degree to which sensitivity to horizontal retinal disparity is limited by the visibility of the monocular half-images, the ability to encode absolute disparity, or the ability to encode relative disparity. Responses were recorded from male and female human participants at average ages of 5.3 ± 1.6 months, 4.7 ± 1.3 years, and 25.3 ± 6 years. Horizontal disparity sensitivity was measured using planar stereograms that modulated absolute disparity and stereograms portraying disparity gratings that additionally contained relative disparity. Disparity thresholds for absolute disparity changed little over development, but those for relative disparity changed by a factor of ∼10. SSVEPs were also recorded in response to contrast and blur modulation of dynamic random-dot patterns to measure sensitivity to the spatiotemporal content of the monocular half-images. Equating subjective contrast and blur levels between infants, children, and adults based on these measurements did not equate disparity sensitivity. The protracted developmental sequence for horizontal relative disparity coding shown in our measurements is not simply inherited from immaturities in encoding absolute disparity or retinal image contrast but rather reflects immaturities in the computations needed to represent relative disparity that likely involves extrastriate cortical areas where relative disparity is first extracted.
Right-lateralization of the visual word form area after left-hemisphere perinatal stroke
Authors: Seydell-Greenwald Anna , Vladyko Natalya , Chambers Catherine E , Gaillard William D , Landau Barbara , Newport Elissa L
Published: January 2025

In literate adults, an area along the left posterior fusiform gyrus that is often referred to as the “visual word form area” (VWFA) responds particularly strongly to written characters compared to other visually similar stimuli. Theoretical accounts differ in whether they attribute the strong left-lateralization of the VWFA to a left-hemisphere bias towards visual features used in script, to competition of visual word form processing with that of other visual stimuli processed in the same general cortical territory (especially faces), or to the well-established left-lateralization of the language system.

Here we used functional magnetic resonance imaging to test the last hypothesis by investigating lateralization of the VWFA in participants (male and female) who have right-hemisphere language due to a large left-hemisphere perinatal stroke. Demographically matched Controls were included for comparison. All participants had intact language skills and were proficient readers; age at testing ranged from 9.75 years to early adulthood.

Individual whole-brain activation maps contrasting activation during rapid presentation of pseudowords and pictures of places, and analyses comparing activations during these conditions in independently defined VWFA regions of interest in left and right ventral occipitotemporal cortex, both demonstrated that while visual word form processing was left-lateralized in Controls, it was right-lateralized in participants with left-hemisphere stroke. This was despite the fact that the tissue normally occupied by the VWFA was not damaged by the stroke. This provides compelling evidence that the lateralization of the VWFA indeed follows that of the frontotemporal language system.

Significance StatementThe visual word form area (VWFA) in healthy adults is almost always lateralized to the left hemisphere. One hypothesis is that this is due to co-localization with the LH language network. This study provides support for this hypothesis from a rare participant group with RH language; we find that their VWFA is also right-lateralized. Our findings also support the notion that the hemispheres are equipotential early in life, with a fully functional language system – including the VWFA – able to develop in the RH if the LH is damaged. These findings contribute to our understanding of functional brain organization and plasticity, with potential implications for rehabilitation approaches for adults with reading impairments due to acquired brain injury.
Phasic Dopamine Release in the Nucleus Accumbens Influences REM Sleep Timing
Authors: Toth Brandon A. , Burgess Christian R.
Published: January 2025

Based on the activity of dopamine (DA) neurons during behavioral states, the DA system has long been thought to be foundational in regulating sleep–wake behavior; over the past decade, advances in circuit manipulation and recording techniques have strengthened this perspective. Recently, several studies have demonstrated that DA release in regions of the limbic system is important in the promotion of REM sleep. Yet how DA dynamics change within bouts of sleep, how these changes are regulated, and whether they influence future state changes remains unclear. To address these questions, in mice of both sexes we used in vivo fiber photometry and inhibitory optogenetics to identify a specific role of DA transients in the nucleus accumbens (NAcc) in state transitions from NREM sleep. We found that DA transients increase their frequency and amplitude over the duration of NREM sleep and that this increase is more pronounced during NREM bouts that transition into REM sleep. Next, we found that DA transients in NREM sleep are influenced by changes in REM sleep pressure. Finally, we show that transient DA release in the NAcc plays a functional role in regulating the timing of REM sleep entrances, as inhibition of midbrain DA neuron terminals in the NAcc prolonged bouts of NREM sleep and decreased the frequency of bouts of REM sleep. These findings demonstrate that DA release in the NAcc is dynamically regulated by sleep pressure and has a functional role in transitions from NREM sleep, particularly those into REM sleep.
Temporally Dissociable Neural Representations of Pitch Height and Chroma
Authors: Chang Andrew , Poeppel David , Teng Xiangbin
Published: January 2025

The extraction and analysis of pitch underpin speech and music recognition, sound segregation, and other auditory tasks. Perceptually, pitch can be represented as a helix composed of two factors: height monotonically aligns with frequency, while chroma cyclically repeats at doubled frequencies. Although the early perceptual and neurophysiological mechanisms for extracting pitch from acoustic signals have been extensively investigated, the equally essential subsequent stages that bridge to high-level auditory cognition remain less well understood. How does the brain represent perceptual attributes of pitch at higher-order processing stages, and how are the neural representations formed over time? We used a machine learning approach to decode time-resolved neural responses of human listeners (10 females and 7 males) measured by magnetoencephalography across different pitches, hypothesizing that different pitches sharing similar neural representations would result in reduced decoding performance. We show that pitch can be decoded from lower-frequency neural responses within auditory-frontal cortical regions. Specifically, linear mixed-effects modeling reveals that height and chroma explain the decoding performance of delta band (0.5–4 Hz) neural activity at distinct latencies: a long-lasting height effect precedes a transient chroma effect, followed by a recurrence of height after chroma, indicating sequential processing stages associated with unique perceptual and neural characteristics. Furthermore, the localization analyses of the decoder demonstrate that height and chroma are associated with overlapping cortical regions, with differences observed in the right orbital and polar frontal cortex. The data provide a perspective motivating new hypotheses on the mechanisms of pitch representation.
Uso de práticas integrativas e complementares e qualidade de vida de graduandos em enfermagem
Authors: Santos Gabrielli Sousa dos , Almeida Marcella Cecílio de , Souza Raquel Valente de , Barros Joyce Assunção , Nicolussi Adriana Cristina
Published: January 2025

Objetivo: avaliar o uso de práticas integrativas e complementares e associar com a qualidade de vida de estudantes de enfermagem. Métodos: estudo transversal, realizado com acadêmicos de enfermagem. Utilizou-se um questionário sociodemográfico/clínico-terapêutico e o WHOQOL-Bref para avaliar a qualidade de vida. Os dados foram examinados por meio de estatísticas descritivas, empregando-se o Teste de Levene para Igualdade de Variâncias e o Teste t de Student para averiguar a diferença das médias dos domínios de qualidade de vida entre os grupos. Resultados: participaram 73 estudantes; destes, os que realizavam alguma prática integrativa e complementar notaram melhorias com o uso e recomendariam a outras pessoas. As terapias mais utilizadas foram homeopatia, florais, meditação, yoga, musicoterapia e reiki. Quanto à qualidade de vida, na comparação entre os grupos, os estudantes que utilizam alguma prática integrativa apresentaram melhores médias para todos os domínios do que os que não utilizavam. Conclusão: poucos acadêmicos conheciam e usavam práticas integrativas e complementares e a qualidade de vida daqueles que utilizavam as práticas foi melhor, se comparados com aqueles que não as usavam. Contribuições para a prática: os resultados podem oferecer subsídios para o fortalecimento dos benefícios do uso das práticas integrativas nesse cenário acadêmico.
Medo do morrer e da morte entre estudantes de enfermagem
Authors: Mestre Gabriela de Almeida , Batista Ana Carolaine de Souza , Silva Júlia de Souza Soares da , Fernandes Flávia Emília Cavalcante Valença , Cañon-Montañez Wilson , Hernández-Gamboa Adriana Elena , Silva Rudval Souza da
Published: January 2025

Objetivo: analisar o medo do processo de morrer e da morte entre estudantes de Enfermagem. Métodos: estudo observacional, transversal, com uma amostra de 277 discentes de Enfermagem dos três campi de uma Universidade Pública, que responderam a Escala de Medo da Morte de Collett-Lester. Para a análise foram realizados os testes Kruskal-Wallis e Mann-Whitney. Resultados: as variáveis: a seu morrer, a morte dos outros e o morrer dos outros, tiveram resultados superiores ao ponto de corte preestabelecido e os resultados mostram que o medo da morte varia significativamente entre os estudantes de enfermagem. Conclusão: confirmou-se que o medo do processo de morrer e da morte variam significativamente entre os estudantes de enfermagem, sendo influenciado por fatores demográficos e experiências pessoais, como sexo, religião, ter ou não filhos e experiência de perda de um ente próximo e o semestre acadêmico em curso. Contribuições para a prática: tais achados sinalizam a importância do letramento em Tanatologia na formação em Enfermagem. Os futuros profissionais enfrentarão demandas biopsicossocioespirituais inerentes ao processo de morrer e à morte, um desafio pessoal e profissional no cuidar em enfermagem e saúde.
Best practices in the management of thyroid dysfunction induced by immune checkpoint inhibitors
Authors: Yamauchi Ichiro , Yabe Daisuke
Published: January 2025

Immune checkpoint inhibitors (ICIs) frequently cause immune-related adverse events (irAEs), with thyroid irAEs being the most common endocrine-related irAEs. The incidence of overt thyroid irAEs was in the range of 8.9–22.2% in real-world settings, typically triggered by antibodies against PD-1 and PD-L1 and rarely by anti-CTLA-4 antibodies alone. The representative clinical course involves biphasic changes in thyroid function: transient thyrotoxicosis and subsequent persistent hypothyroidism. The identified risk factors for thyroid irAEs include the presence of thyroid autoantibodies, thyroid uptake on 18F-FDG-PET, prior use of tyrosine kinase inhibitors (TKIs), high BMI and high thyroid-stimulating hormone levels. There is evidence that overt thyroid irAEs are associated with good prognosis, at least in non-small cell lung cancer. Although the clinical features have been well clarified, the management strategies require further refinement. Routine monitoring of thyroid function every 4–6 weeks during ICI therapy is recommended for early detection of thyroid irAEs. While thyrotoxicosis generally requires observation only, hypothyroidism should be promptly treated with levothyroxine replacement. Continuation of ICI therapy is typically feasible in patients with thyroid irAEs, provided their overall health remains stable. However, these strategies were largely based on clinical experience with monotherapy. As combination ICI therapies have been developed as first-line treatments, antitumor agents may modify the clinical features of thyroid irAEs. For example, cytotoxic agents can delay the onset of thyroid irAEs, while TKIs are often linked to early-onset hypothyroidism, independent of ICI use. Given the increasing diversity and complexity of cancer immunotherapy, it is essential to vigilantly screen for thyroid irAEs.
Water hyacinth: A sustainable resource for water phytoremediation, ethanol production, nutrient improvement and the dynamics of microbial C and N in vermicompost
Authors: Punitha Amirtha Mani , Priyatharshini Chellappa Josephine , Alghmdi Mai Ahmad , Al Farraj Dunia A , Elshikh Mohamed Soliman , Ali M. Ajmal , Arokiyaraj Selvaraj , Hamlin Stalin Rinna
Published: January 2025

The water hyacinth Eichhornia crassipes is a rapidly growing weed that grows in shallow fresh water. It can be used for the removal of nutrients and heavy metals from water, as feedstock for biofuels, and as a bulking agent for the vermicompost process. The present study focused on the use of water hyacinth plants for nutrient and heavy metal removal from water. Water hyacinth removed >95% of ammonium nitrogen, nitrite, and nitrate from the water. The bioaccumulation potentials of water hyacinth for Cu, Cd, Cr, As, Li, and Zn after 30 days of treatment were 80 ± 2.3%, 78.6 ± 3.2%, 73.2 ± 1.2%, 69.6 ± 2.1%, 65.5 ± 1.9%, and 44.2 ± 2.2%, respectively. The heavy metal accumulation in water hyacinth was in the following order: Cu>Cd>Cr>As>Li>Zn. Water hyacinth was pretreated with acid and base. It was further digested with cellulolytic enzymes, and Saccharomyces cerevisiae was further inoculated to produce ethanol in a liquid culture. The ethanol yield was 0.09 mL/mL culture. Water hyacinth was cut into small pieces, mixed with goat manure and used for vermicomposting. The microbial C content of the vermicompost ranged between 398 ± 12.8 and 537 ± 11.2 µg/g, and the microbial N content ranged from 104.4 ± 2.2 to 254.9 ± 2.2 µg/g. The vermicompost had an 84.3 ± 2.2% germination index after 48 h in the pots treated with 20% vermicompost.
Caracterización elemental y morfológica de una tableta de gemfibrozilo usando la técnica de fluorescencia de rayos-X dispersiva en energía
Authors: Bravo Cabrejos Jorge Aurelio , Mejía Santillán Mirian Esther
Published: January 2025

Applying the analytical technique of energy dispersive X-ray fluorescence (EDXRF) the elemental composition of the film that coats gemfibrozil medicinal tablets has been determined. The respective EDXRF spectrum shows relatively intense characteristic K X-rays peaks of titanium about a hundred times more intense than the other X-ray peaks present in the spectrum. The quantitative analysis of this spectrum, based on the assumption that the material within the tablet in uniformly distributed, shows that the calculated amplitude of the K$_{\beta}$ X-rays of titanium is about 25\% larger than the recorded peak indicating that the titanium is distributed as a film. The literature gives reference to the application of titanium oxide for coating tablets. Based on this hypothesis the thickness of the TiO$_{2}$ oxide film is calculated to be 1.90 $\mu$m.
Development of a portable low-cost PC-independent accelerometer for multiple purposes
Authors: Montoya Erick
Published: January 2025

Modern seismographs are sensitive enough to record seismic waves with amplitudes as small as a few micrometers, but their manufacturing cost is also very high. This is a major difficulty when studying the dynamic response of buildings to earthquakes since usually large arrays of seismographs are needed to carry out such a study, making the affordability of this type of research in developing countries (regions where old or porrly-constructed buildings are more common) virtually impossible. In view of this problem, in this paper the prototype (named MiSismo) for an inexpensive PC-independent seismograph is presented, along with its most outstanding features (such as backup power system, sample rate selection, earthquake detection and email service), proposed applications and drawbacks. The sensitivity and noise density of the sensor of MiSismo (MMA8451Q, a MEMS accelerometer) are several orders of magnitude lower and higher respectively than those of the most commercially-available seismographs, but the manufacturing cost of MiSismo is also one order of magnitude lower. The performance of MiSismo was tested with real and simulated earthquakes. The results show that MiSismo can detect local earthquakes with magnitude as small as 4.8, and the data is clear enough to obtain the basic seismic parameters of moderate-to-large earthquakes. This characteristic of MiSismo could be useful for educational purposes. On the other hand, it was found that the measurements of MiSismo clearly detect the resonance effect on buildings, indicating that MiSismo could also be used for structural studies. Finally, the results of a simulated strong earthquake with subsequent blackout confirmed that the backup power system of MiSismo works perfectly since no loss of data was observed.
Propiedades estructurales, magneticas y superconductoras del sistema RNiBC (R=Tierra rara): Una comparacion con las propiedades del sistema RNIBC
Authors: Baggio-Saitovitch E.
Published: January 2025

Cristallographic structure
Evaluation of animal welfare during the unloading of cattle through behavioural indicators in commercial fairs in the Ñuble region, Chile
Authors: Letelier C. Reinaldo , Gädicke L`H. Paula , Sanhueza L. Katherine , Bruna C. Paulina
Published: January 2025

El objetivo de este trabajo fue evaluar el comportamiento y manejo animal de los bovinos en dos ferias de comercialización de ganado en la región de Ñuble durante 2019. El estudio observacional se realizó en 1007 bovinos, utilizando patrones para registrar indicadores de comportamiento e interacciones humano-animal de manera simultánea, durante las cuatro etapas de descarga de los animales en la feria (apertura de las puertas del camión, descenso de la rampa de descarga, permanencia en la manga de descarga y permanencia en la rampa de ganado). Vocalizaciones y micción fueron los indicadores de comportamiento predominantes, y las interacciones auditivas (gritos, sonidos artificiales y silbidos) fueron las interacciones humano-animal más importantes. Solo en la feria Bulnes se evidenció una asociación grupal entre los bovinos, donde su comportamiento se vio afectado por las interacciones humano-animal (p<0.05); sin embargo, no fue suficiente para afirmar que las interacciones humano-animal estén afectando el comportamiento bovino en las dos ferias. Se concluye que no se encontró evidencia de que las personas estén afectando directamente el comportamiento bovino.
Variaciones metabólicas y endocrinas durante el periparto y primera fase de lactancia en sistemas lecheros en trópico bajo
Authors: Campos-Gaona Rómulo , Correo-Orozco Adriana , Vélez-Terranova Mauricio
Published: January 2025

The aim of this study was to characterize the metabolic status of specialized and dual-purpose dairy cows under lowland tropical dairy systems in Colombia, by evaluating body condition, serum concentrations of metabolites and hormones, in the transition period and up to 105 days post-partum, through multivariate analysis techniques. To understand the joint variation of hormones and metabolites evaluated during the experimental phase, the 21 variables under study (haemoglobin, haematocrit, NEFA, BHB, glucose, cholesterol, triglycerides, urea, protein, albumin, globulin, AST, ALT, GGT, body condition, T3, cortisol, insulin, leptin, prolactin, GH), were analysed from a multivariate approach. A cluster analysis and principal component analysis (PCA) were performed to reduce the dimensionality of the information, and to identify the representative variables to explain the variation in the data. It was possible to establish the grouping of the evaluated periods into three clusters, by unifying periods with similar metabolic and hormonal behaviours, with an expected biological sense during and after parturition. The work allowed to know the serum concentrations of metabolites and hormones in the peripartum and first phase of lactation of dairy cows in tropical conditions and their grouping by PCA facilitated the generation of a multivariate evaluation index in the puerperium.
Efecto de la suplementación con dos genotipos del forraje de cebada (Hordeum vulgare L.) sobre producción y calidad de leche
Authors: Llacsa Mamani Javier , Viera Valencia Mario , Gómez Bravo Carlos
Published: January 2025

The aim of this research was to evaluate the effect of supplementation with two barley forage genotypes on milk production and quality in grazing cows. The genotypes evaluated were a local barley (Hordeum vulgare L.) and UNALM 96 M6h-326 barley in the district of Sincos, Junín (Peru). The experiment was conducted with 16 Brown Swiss - creole crossbred cows in second lactation and body weight of 385 ± 17 kg. Under a simple change design, the animals were divided into two groups for supplementation with 4 kg/day with one of the two barley forages. Supplementation was carried out in two stages of 13 days each, the first 8 days being for adaptation and the following 5 days for evaluation of milk production and composition. Milk production per cow/day was increased with UNALM 96 M6h-326 barley forage compared to the local variety (4.0 vs. 3.57 kg. p<0.05). Likewise, higher urea content in milk was obtained, but the fat content was lower (p<0.05).
Determinación del diámetro medio y porcentaje de medulación de fibras representativos de vellones de alpaca
Authors: Quispe Peña Edgar , Aliaga Gutiérrez Jorge , Gamarra Bojorquez Jorge , Mueller Joaquín , Sacchero Diego , Marrero Saucedo Freddy , Quispe Bonilla Max David
Published: January 2025

The evaluation of the mean fibre diameter (MFD) and the incidence of representative medullation of alpaca fleeces in 10 g samples of fibres from the mid-rib area is usually carried out to identify fine animals in genetic improvement programmes. Subsamples are usually taken from each sample to determine the MFD with some type of measuring instruments; however, due to the great variability of the diameter between staples, between fibres and along the same fibre, there is no consensus on the number of subsamples to use to achieve a representative result for the sample. In the present study, results from a range of subsamples were evaluated against the result of the total subsamples for MFD measurements and for measurements of the following additional variables of interest in alpaca fleeces: total percentage of medullated fibres (PMedT), percentage of fibres with fragmented medulation (PMedFrag), with discontinuous medulation (PMedDisc), with continuous medulation (PMedCont), strongly medullated (PFuertMed), mean diameter of medullated fibres (MDFMed), mean diameter of fibres with fragmented modulation (MDFFrag), mean diameter of fibres with discontinuous medulation (MDFDisc), mean diameter of fibres with continuous medulation (MDFCont) and mean diameter of strongly medullated fibres (MDFFuertMed). Samples of 10 g were taken from the mid-rib area of 62 alpacas. From a group of 30 samples, 17 subsamples were taken, allowing 510 evaluations; and from the second group of 32 samples, 9 subsamples were extracted, allowing 288 evaluations. The subsamples were analysed with the Fiber EC and Fiber Med instruments and the data obtained were statistically analysed using Spearman and Pearson correlations, paired mean tests and variance components estimated with a linear model that includes sample and subsample nested in sample. It is concluded that to achieve a correlation greater than 0.990, at least three to five subsamples are required in the evaluation of MFD, two or three subsamples in the evaluation of PMedT, PMedFrag, PMedDisc and PMedCont with their respective MFD and at least five subsamples in the evaluation of PFuertMed and its MFD.
Conocimientos, prácticas y actitudes asociadas a signos clínicos afines a equinococosis quística en estudiantes y profesores de educación secundaria del distrito altoandino de Huancarama, Perú
Authors: Valderrama P. Aldo , Pineda S. Martin , Mayta L. María , Chumbez S. Gepsi , Velarde W. Nathaly
Published: January 2025

El objetivo del estudio consistió en determinar los conocimientos, prácticas y actitudes asociadas a signos clínicos afines a equinococosis quística de estudiantes y profesores de educación secundaria del distrito de Huancarama, departamento de Apurímac, Perú, zona endémica de esta parasitosis. La investigación fue de nivel básico, de diseño analítico y de corte trasversal. Se obtuvo el asentimiento y los consentimientos informados correspondientes. Se determinaron los signos clínicos, conocimientos, prácticas y actitudes sobre equinococosis quística, así como el estado nutricional y los valores de hemoglobina de los participantes. Los signos clínicos de equinococosis quística más frecuentes fueron debilidad (34.9%), desorientación (34.6%), somnolencia (32.7%) y dolor abdominal (31.4%). El sexo masculino fue un factor protector contra dolor abdominal, náuseas, vómitos, tos, dolor torácico, disnea, anorexia, pérdida de peso, malestar y somnolencia. Residir en zona rural también fue un factor protector de padecer dolor abdominal, náuseas, tos, dolor torácico, disnea, anorexia, pérdida de peso, debilidad, malestar, ascitis, desorientación y somnolencia. No obstante, beber agua sin hervir constituyó un factor de riesgo de náuseas, anorexia, pérdida de peso, malestar y desorientación. Realizar faenamiento de ganado en la vivienda estuvo asociado a tos, desorientación y somnolencia.
Human and Machine: “Creative Understanding” in Translation Studies
Authors: Lapteva Irina V. , Kuznetsova Ekaterina D.
Published: January 2025

The article presents an analysis of the concept “creative understanding” in the context of literary translation. Based on the works of M. M. Bakhtin, O. R. Demidova, V. I. Karasik, V. P. Furmanova and other researchers, the authors consider the text of the translation as a cultural phenomenon, and the translation process as creative understanding, the necessary conditions of which are: immersion into the cultural and historical context, creativity, emotional coloring, the use of artistic elements. The authors point out the need for cooperation between human and automated intelligence when translating a text into another language.
Application of modern means and technologies for monitoring the microclimate in greenhouses
Authors: Ivanova Y. , Ivanov S. , Peychev K. , Belovski I.
Published: January 2025

Abstract. Modern tools and technologies are increasingly used to monitor the main parameters of the microclimate in greenhouses. In this article, an overview and comparative analysis of modern sensor devices applicable in the measurement of physical parameters in greenhouses is made. The various technologies and components for automation of microclimate monitoring are considered. The possibilities offered by management software solutions are considered. The possibilities of IoT technologies for automating processes in greenhouses are described.
Disseminated nontuberculous mycobacterial infection in the context of interferon-gamma autoantibody syndrome: A case report and review of the literature
Authors: Jordan Victoria , Pickles Robert
Published: January 2025

Interferon-gamma (IFN-γ) autoantibody syndrome is an emerging clinical entity that has been associated with disseminated non-tuberculous mycobacterial infection (dNTM) particularly in healthy young people, a population not previously thought to be at particular risk. A 29-year-old South-East Asian man presented with several weeks of fever, cough, lymphadenopathy, and constitutional symptoms while working on an international cargo ship, deteriorating rapidly with a sepsis-like syndrome. Eventually lymph node and sputum cultures revealed a diagnosis of dNTM infection with growth of both Mycobacterium persicum and Mycobacterium abscessus. He was commenced on rituximab as well as combination anti-mycobacterial therapy with good clinical response. This case highlights some of the difficulties faced by patients with dNTM in the context of IFN-γ autoantibodies, particularly delayed diagnosis, and lack of evidence base surrounding optimal management. Further research into long-term outcomes and treatment is required as well as increased awareness among clinicians.
От философии языка к философии религии: этносемиотические идеи С.А. Токарева и Ю.В. Кнорозова
Authors: Kostin Nikołaj
Published: January 2025

The article is devoted to a little-studied phenomenon in the history of Russian philosophy of the late period (XX century) – the philosophy of religion by Yu.V. Knorozov and S.A. Tokarev. This approach in the field of philosophy of religion is directly related to another humanitarian research program of researchers – ethnosemiotics. Based on the ethnographic, ethnosemiotic and general theoretical works of Tokarev and Knorozov, the article provides a systematization and description of this original and authentic version of the philosophy of religion (which was originally developed to study local religious cults and traditions). The direct connection of this philosophical phenomenon with other disciplines is shown: archeology, geography, ethnography and theoretical linguistics.
Determinants for the Adoption of Market Technologies in the Curriculum of Undergraduate Accounting Courses in Latin America
Authors: Quiraque Elcídio Henriques , Domingues Daiane Garcia , Frare Anderson Betti , Barbosa Marco Aurélio Gomes
Published: January 2025

The aim of this article is to analyze the perception of university professors regarding the determinants of adopting market technologies in the curriculums of undergraduate accounting courses in Latin America. This study is based on the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2). A survey was conducted with professors from undergraduate accounting courses located in the countries that make up Latin America, resulting in a sample of 151 professors distributed among 16 countries. The data was analyzed through a mixed-method approach using Partial Least Squares – Structural Equation Modeling and fuzzy-set Qualitative Comparative Analysis. The findings show the symmetrical influence of habit, performance expectancy, and social influence on the adoption of market technologies regardless of age, academic experience or gender. Furthermore, various asymmetrical combinations of conditions bring about a high adoption of market technologies in accounting curricula, with performance expectancy being present in all possible combinations.
Entre Educação, Filosofia e Educação Matemática, Filosofia da Educação Matemática
Authors: Bicudo Maria Aparecida Viggiani , Garnica Antonio Vicente Marafioti
Published: January 2025

Resumo: O texto apresenta a entrevista, realizada com Maria Aparecida Viggiani Bicudo, sobre Filosofia da Educação Matemática. A esse tema central vinculam-se outros assuntos, como a experiência da entrevistada no domínio da gestão universitária, o movimento que a levou da formação inicial em Educação aos estudos filosóficos, a criação do Programa de Pós-Graduação em Educação Matemática da Unesp de Rio Claro e a perspectiva de, envolvida no mundo acadêmico, ser mulher e mãe.
Impact of nihilistic trend on the style of dramatic stage scenery
Authors: Zhang Kai
Published: January 2025

Abstract: The purpose of this article is to explore how nihilism, as a philosophical trend of thought, profoundly affects the stage design of modern drama. Nihilism emphasizes the lack of inherent meaning in the world and the absurdity of human existence. Based on this, this article puts forward the argument that nihilism has had a significant impact on the modern drama. Through simplification, abstraction and subversive stage design, the audience is prompted to re-examine the relationship between drama and reality at the visual and psychological levels. The article will explore the concept, generation and artistic expression of nihilism, compare the traditional Western and Chinese theatrical stage set styles, and demonstrate the unique influence of nihilism on theatrical stage sets from the four aspects of stage design, expression techniques, space use and subversion of traditional theatrical forms. Through the analysis of the works of dramatists, such as Pinter, it shows how nihilism is embodied in the specific design of the stage set to support the argument.
Between emptiness and reality: from the white space in Chinese painting to the philosophy of form in western art
Authors: Wang Liang , Wang Baoqing
Published: January 2025

Abstract: In the field of art, the contrast between reality and virtuality is a common technique of expression. In order to comprehensively explain the essence of beauty and enrich the aesthetic concept of art, this article compares and analyzes the concepts of “emptiness” and “reality” in Chinese and Western art from the perspectives of the blank space in Chinese painting and the formal philosophy of Western art. It explores the different understandings and approaches to space, blank space and form under two different art systems. Chinese art emphasizes the importance of emptiness and artistic conception, reflecting the emphasis on wholeness and intrinsic meaning. Western art, on the other hand, expresses concern for the relationship between individuals and the external world through the pursuit of rationality and realism. This comparison reveals the profound influence of different aesthetic traditions on social thought and aesthetic views. By reflecting on and understanding the aesthetics of reality and virtuality in different cultural backgrounds, it helps to enrich individual aesthetic experiences and promote social development.
ENDOSCOPIC SURGERY FOR TREATING SPINAL STENOSIS: AN INTEGRATIVE REVIEW OF RANDOMIZED CLINICAL TRIALS
Authors: Aparício Rafael Augusto da Silva , Oliveira Rodrigo Freitas Maringoni de , Pinto Felipe de Almeida , Gorios Carlos , Zanon Lorran Azevedo , Masi Alessandra
Published: January 2025

ABSTRACT Background: Spinal stenosis refers to the narrowing of the spinal canal which can generate clinical symptoms secondary to the spinal cord injury itself, or even root involvement. The traditional open surgical procedure to correct spinal stenosis is highly traumatic and risky, and with the development of surgical techniques, endoscopic procedures have been widely used in treating said stenosis, achieving good results with minimally invasive management. Aim: To conduct a literature review regarding endoscopic techniques for correcting spinal stenosis. Method: This is an integrative literature review that surveyed the PUBMED database using the following search strategy: spinal[title] AND stenosis[title] AND surgery[title]. Only randomized clinical trials published in the last 10 years were included in the sample. Results: A total of 13 articles were identified that met the previously established search strategy, all of which were included in the review. Conclusion: The reviewed studies showed that endoscopic surgery to correct spinal stenosis could offer adequate decompression of neural elements, resulting in shorter hospital stays, faster recovery and favorable operative results. Level of Evidence IV, evidence from descriptive (non-experimental) or qualitative studies.
Análise da rugosidade de agregados reciclados e a influência na aderência pasta-agregado em compósitos cimentícios: uma nova abordagem com microscopias de superfície
Authors: Estolano Amanda Marques Lopes , Silva Diego Henrique Alves da , Sá Larissa Fonseca Torres , Cruz Felipe Mendes da , Lima Nathalia Bezerra de
Published: January 2025

RESUMO A resistência mecânica de concretos e argamassas são influenciados pelas características dos agregados, incluindo forma, composição e rugosidade. O objetivo deste trabalho é investigar a influência da rugosidade de agregados graúdos reciclados na aderência com a argamassa cimentícia. A rugosidade dos agregados foi variada através de tratamento mecânico e lixamento manual para obtenção de diferentes níveis e foi quantificada através da microscopia confocal a laser. Através do método de imersão em argamassa, desenvolvido nesse estudo, foi analisada a zona de transição interfacial visualizada por meio da microscopia eletrônica de varredura. Os resultados indicam que o tratamento mecânico deve ser realizado de forma controlada para garantir o equilíbrio entre remover a argamassa aderida e não gerar uma superfície excessivamente rugosa que comprometa a interação com a pasta cimentícia. Concluiu-se que a topografia da superfície é um fator determinante para a aderência pasta-agregado e melhoria no comportamento mecânico do concreto fabricado com resíduo de construção e demolição. Rugosidades moderadas, com vales e depressões bem definidos e alternados, favorecem a penetração da pasta cimentícia e criam uma ligação interfacial mais densa.
Comportamento mecânico e análise de padrão de fissuração de compósitos geopoliméricos reforçados com fibras de sisal
Authors: Pessanha Ana Carolina Lemos de Souza , Garcia Sergio Luis González , Dias Dylmar Penteado , Moreira Pamella Inacio , Alves Gabryel de Carvalho
Published: January 2025

RESUMO Os geopolímeros são materiais que apresentam alta resistência inicial à compressão, além de apresentarem resistência à altas temperaturas, a sulfatos e a ácidos. Porém, é um material cerâmico de comportamento frágil. Para compensar tal fragilidade, diversos tipos de fibras têm sido utilizadas. No presente trabalho, compósitos geopoliméricos reforçados com fibras de sisal foram produzidos e ensaiados à tração direta. Foram avaliadas duas diferentes distribuições de fibras contínuas e alinhadas: fibras distribuídas longitudinalmente e fibras distribuídas a 45°, em ambos os casos foram utilizadas uma fração volumétrica de 3% de fibras. O comportamento de deformação e fissuração foram analisados pela técnica de Correlação de Imagem Digital (CID). Os resultados encontrados foram comparados com outros resultados presentes na literatura, demonstraram similaridade com os estudos analisados. Os compósitos apresentaram comportamento strain-hardening com a formação de múltiplas fissuras, com o aumento da resistência após a formação da primeira fissura. Os compósitos com fibras distribuídas longitudinalmente apresentaram melhor desempenho, demonstrando que o desempenho dos compósitos depende da orientação de distribuição das fibras em relação ao carregamento aplicado.
Aquatic and palustrine plants of restinga in a Ramsar site in the easternmost Amazon, Brazil
Authors: Alves N. P. F. , Pestana M. C. A. , Pires S. F. , Penha J. C. A. , Cardoso-Neto V. R. , Scatigna A. V. , Saraiva R. V. C.
Published: January 2025

Abstract Aquatic and palustrine plants are a group of plants that have morphological and anatomical adaptations to occupy permanent or temporary aquatic environments. In this study, we carried out the first floristic survey of aquatic and palustrine plants in restingas (restinga swamps and swamp forests) of a Ramsar site in the municipality of Guimarães, western coast of Maranhão State and easternmost Amazon, Brazil. In total, 52 species of 43 genera and 28 families were collected between July 2022 and October 2023, during the dry and rainy seasons. Voyria aphylla (Jacq.) Pers. is a new record for Maranhão. Melastomataceae (9 spp.) was the most representative family, followed by Fabaceae and Plantaginaceae (4 spp. each). Palustrine and emergent plants accounted for 58% and 31% of the species richness, respectively. This study adds important information for local and national policies to ensure biodiversity conservation of the plant biodiversity in Maranhão’s coastal ecosystems.
Polymitarcyidae Banks, 1900 (Insecta, Ephemeroptera) from the Western Region of Pará, Brazil
Authors: Corrêa Amanda da Silva , Oliveira Laura Almeida de , Lima Lucas Ramos Costa , Couceiro Sheyla Regina Marques
Published: January 2025

Abstract: Polymitarcyidae has a worldwide geographic distribution. Their nymphs are adapted to the fossorial habit, while the adults (imagos) have atrophied legs, except for the anterior legs of the males. This study represents the first survey of this family in the western region of Pará. For this purpose, we collected nymphs and adults. Nymphs were captured using aquatic entomological nets and sieves, while adults were obtained using light traps and flight interception. In addition, we used online sources, such as the Brazilian Fauna Taxonomic Catalog, the EPHEMBRAZIL platform and the Ephemeroptera da América do Sul website. The survey revealed the presence of three genera and 13 species of Polymitarcyidae in the region, including six new records for the state of Pará. These results highlight the importance of geographic distribution surveys to expand our knowledge about biodiversity.
Molecular and camera trap data confirm the occurrence of Dasypus septemcinctus (Linnaeus, 1758) in Mato Grosso do Sul State, Brazil
Authors: Desbiez Arnaud L.J. , Massocato Gabriel F. , Melo-Dias Mateus , Yogui Débora R. , Silva Kena Ferrari Moreira da , Gestich Carla Cristina , Galetti Jr Pedro M.
Published: January 2025

Abstract: Understanding the distribution range of a species is crucial for conservation efforts. Yet, precise confirmation of their presence throughout predicted areas can be a challenge. Molecular tools, associated with traditional survey methods, can help in species identification, settling the misidentification of specimens. This study uses a combination of a molecular approach with morphological features to confirm records of the seven-banded armadillo (Dasypus septemcinctus) in Mato Grosso do Sul (MS), Brazil, at the southern edge of its known range. Despite extensive camera trapping and roadkill monitoring efforts, we obtained only two records of D. septemcinctus, both in the northeast region of MS. Molecular analysis confirmed the morphological identification, eliminating any doubt about the identification of the specimen. The confirmation of D. septemcinctus occurrence in the state of MS, not only expands our knowledge of this widely distributed but poorly studied species, but also highlights the importance of a local park (Parque Natural Municipal do Pombo) for Xenarthra conservation..
Techniques for randomization and allocation for clinical trials
Authors: Miola Anna Carolina , Espósito Ana Cláudia Cavalcante , Miot Hélio Amante
Published: January 2025

Abstract Intervention studies require all participants to originate from the same population, with random allocation to intervention groups to ensure comparability. Randomization is crucial for minimizing confounding factors, allowing differences in outcomes to be attributed to the intervention. Simple randomization performs well for large samples (>100 per group), but smaller samples may require block or stratified randomization to balance group sizes and covariates. When randomization isn't feasible, quasi-randomized methods (e.g., based on dates or enrollment order) can help but must compensate with multivariate adjustments. Moreover, blinding and allocation concealment enhance internal validity and reproducibility. Allocation concealment (e.g., sealed envelopes) prevents bias during participant assignment while blinding mitigates detection and performance biases. Precise methodological descriptions in clinical trial registrations and publications enhance study reliability and reproducibility, highlighting the importance of rigorous planning and transparent reporting in intervention research. This article reviews the key concepts of randomization, blinding, and allocation concealment in interventional studies
One approach is that we learn together, regardless of the language, regardless of the school subject: the translanguaging stance of teachers in a migration school scenario in southern Brazil
Authors: Welp Anamaria , Sampaio Eduardo , Malta Gláucia Helena Sarmento
Published: January 2025

ABSTRACT This article presents the results of a study conducted at Escola das Pontes, a school in southern Brazil that serves local, immigrant, and refugee students, primarily from Haiti and Venezuela. The research is grounded in the theory of translanguaging, which offers a humanizing approach that places students and their diverse repertoires at the center of learning, breaking down traditional language barriers. Through a critical-collaborative research perspective, the study investigated the educators’ translanguaging stance, i. e., their orientation towards social justice, across different subject areas during a teacher development meeting. The meeting aimed to create a space for educators to discuss their daily experiences and challenges in school. The results suggest most teachers demonstrate a translanguaging stance in their teaching, as they report using students’ language repertoires to leverage language and content learning. This is observed even before their formal introduction to translanguaging theory. Their approach values students’ ways of knowing and promotes linguistic diversity in favor of meaningful education. The teachers’ accounts reveal that learning in their classrooms is not hierarchical, as teachers and students learn together.
O perfil dos estudantes de bacharelado e licenciatura em física no Brasil entre os anos de 2009 e 2022: uma análise a partir do Censo do Ensino Superior
Authors: Ianello Matheus , Watanabe Graciella
Published: January 2025

O perfil dos estudantes brasileiros têm sido foco de diferentes trabalhos na área da educação e ensino. Em especial, tem-se demonstrado que as questões sociais durante a formação, bem como o acesso e a evasão dos cursos, em especial, nas ciências exatas, são problemas históricos que permanecem entre os desafios do ensino superior brasileiro. Os cursos de física, por sua vez, possuem destaque pela dificuldade de manutenção dos estudantes em seus cursos cujas taxas de evasão se sobressaem em resultados da literatura especializada. Diante disso, busca-se neste artigo apresentar um panorama entre os anos 2009 até 2022 do perfil dos estudantes que adentram, se matriculam e permanecem nos cursos de bacharelado e licenciatura nas instituições públicas e privadas no país. Este estudo possui perfil descritivo, contudo, buscando trazer reflexões de seus resultados através da sociologia das desigualdades. Os resultados encontrados a partir dos microdados do Censo Escolar do Inep indicam o embate entre instituições públicas e privadas, bem como a aumento dos cursos à distância que tem se mostrado fundamental para a ascensão das IES privadas nas lutas travadas pelo monopólio das matrículas, em especial, das licenciaturas em física.