bluuebunny/crossref_metadata_2025 huggingface dataset:
SCIENTIFIC SUBSTANTIATION OF PHYSICAL PROPERTIES OF FISH GELATIN
Authors: Bekesheva Adelia Adlerovna , Yakubova Olesya Sergeevna
Published: May 2020

The article presents the advantages of fish gelatin available for nutritional purposes in comparison with gelatin of mammals. Factors forming the basic physical properties of gelatin as a structure-forming agent have been identified. The analysis of melting temperature of jelly and the dynamic viscosity of fish gelatin solutions has been carried out. The melting temperature of jelly prepared from fish gelatin is 4°C lower than the minimum normalized value for mammalian gelatin, which is stipulated by the specific features of their amino acid composition. There has been found an increased value of the parameter “dynamic viscosity” (on average 30 mPa·s) in comparison with the standard value of gelatin of animal origin (on average 23 mPa·s). The molecular weight composition of fish gelatin has been determined. Gelatin has been stated not an individual substance, but a multiphase system consisting of a mixture of linear polypeptides and their aggregates. In the molecular weight distribution of fish gelatin 81.7% falls to a high molecular weight fraction with a mass higher than 100 kDa. Compared with gelatin obtained from the skins of cattle fish gelatin has higher content (by 34.7%) of molecular weight fractions (β- and γ-chains) and lower content (by 36.2%) of α-chains. The predominance of high molecular weight fractions in the composition of fish gelatin causes high rates of dynamic viscosity of its solutions. It was established that the interval of temperature transition ‘fibril-globule’ in fish gelatin is 20-25°C, and in animal gelatin - 28-30°C. It has been inferred that the thermal dependences of the rheological properties of fish and animal gelatin are different. It has been substantiated that collagens of different origin give gelatin with different properties. Physical properties of fish gelatin depend on the amino acid composition of a gelatin molecule, which is determined by the nature of collagen, and on the molecular weight distribution of α-, β-, γ-fractions of gelatin, which is determined by technological factors of gelatin production.
Descripción morfológica y anatómica de un granuloma inflamatorio crónico en Gallo Jabaq colombiano (Gallus gallus domesticus)
Authors: Oviedo-Peñata Carlos Andrés , Molina-Díaz Víctor Manuel
Published: May 2020

Describir la presencia de un granuloma inflamatorio crónico en un gallo Jacab colombiano y su posible relación con la aplicación de fármacos en esta especie, en Montería, Córdoba 2019. Un gallo Jacab (Gallus gallus domesticus), de 2 años de edad ingresa a cirugía en la clínica veterinaria “Julio E. Cuervo”, por presentar un nódulo de 2 cm en la región alar izquierda, de dos meses de evolución, se tomaron imagen radiológica latero lateral, evidenciando una lesión de 2 cm de diámetro en la región escapulo-humeral, se realizó extirpación quirúrgica bajo anestesia inhalada con Isoflurano 2 CAM y se envió a evaluación histopatológica. El diagnóstico patológico describe una neoformación móvil, indolora y consistencia firme, color pardo amarillenta, de 1,5 cm de diámetro, los cortes muestran una lesión, constituida por proliferación de fibras elásticas y fibroblastos fusiformes e histiocitos, con reacción inflamatoria linfoplasmocitoria de aspecto granulomatosa, tratándose de un granuloma inflamatorio crónico.
Keragaman Organisme Pengganggu Tanaman (OPT) pada Tanaman Padi Varietas Unggul Baru (VUB) dan Varietas Lokal pada Percobaan Semi Lapangan
Authors: Sudewi Sri , Ala Ambo , Baharuddin Baharuddin , BDR Muhammad Farid
Published: May 2020

Serangan Organisme Pengganggu Tanaman (OPT) pada tanaman padi apabila tidak ditangani dengan serius akan menurunkan produktivitas tanaman secara signifikan. Keragaman OPT yang menyerang tanaman padi varietas lokal dan varietas unggul baru (VUB) sangat penting untuk diketahui agar dapat dilakukan tindakan pengendalian yang lebih efektif dan efisien. Penelitian dilaksanakan pada bulan Agustus sampai Februari 2018, di Teaching Farm Fakultas Pertanian Universitas Hasanuddin Makassar. Metode yang digunakan pada percobaan semi lapangan ini dengan mengamati secara langsung jenis OPT yang menyerang rumpun tanaman padi, gejala serangan yang ditimbulkan serta menghitung persentase serangan. Pengamatan dilakukan setiap hari, dimulai pada saat tanaman berumur ± 30 hari setelah tanam. Hasil penelitian menunjukkan bahwa OPT yang menyerang VUB dan varietas lokal yaitu Locusta migratoria. L, Sesamia inferens, Cnaphalocrosis medinalis serta patogen penyakit hawar daun bakteri (HDB). Persentase serangan tertinggi terdapat pada VUB Inpari 16 dan Inpari 42 yang terserang HDB mencapai 50% sedangkan varietas lokal Kamba yang diamati memiliki reaksi ketahanan yang agak baik terhadap berbagai serangan OPT dengan persentase serangan ≤25%. Serangan Nilaparvata lugens hanya ditemukan pada varietas Inpari 16. Hasil penelitian ini dapat dijadikan referensi dan sumber informasi agar pengelolaan dan tehnik pengendalian dapat dilakukan secara tepat, cepat, efisien dan efektif.
Pengaruh Rock Phosphate Dan Dolomit Terhadap Distribusi Perakaran Tanaman Kelapa Sawit Pada Tanah Ultisols
Authors: Ginting Eko Noviandi , Pradiko Iput , Farrasati Rana , Rahutomo Suroso
Published: May 2020

Karakteristik morfologi akar tanaman kelapa sawit bervariasi pada berbagai jenis tanah yang disebabkan oleh perbedaan sifat fisik, kimia dan biologi tanah. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian Rock phosphate dan dolomit terhadap karakteristik akar (perkembangan dan distribusi akar tanaman) pada tanah Ultisol. Penelitian dilaksanakan di Kebun Percobaan Aek Pancur milik Pusat Penelitian Kelapa Sawit, Tanjung Morawa, Sumatera Utara. Perlakuan yang dicobakan pada tanaman berumur 19 tahun dalam penelitian ini adalah K (kontrol); D (Dolomit dengan dosis 1 kg/pohon); RP (Rock Phosphate dengan dosis 1 kg/pohon); dan D+RP (Dolomit dan RP dengan dosis masing-masing 1 kg/pohon). Pengamatan dilakukan pada 1/6 bagian piringan dengan radius 0-4,5 m dari pangkal pohon dan kedalaman 0-40 cm. Distribusi perakaran tertinggi terdapat pada radius 0-1 m dari pangkal pohon. Akar primer lebih banyak ditemukan pada kedalaman 20-40 cm, sedangkan akar sekunder dan tersier lebih dominan pada kedalaman 0-20 cm. Aplikasi RP meningkatkan pH tanah sekaligus kandungan P, K, dan Mg pada perakaran. Total kerapatan akar (g/dm3) pada perlakuan RP berturut-turut 47%, 16%, dan 32% lebih tinggi dibandingkan perlakuan K, D, dan D+RP. Aplikasi RP pada penelitian ini dapat memperbaiki sifat kimia tanah, merangsang pertumbuhan akar, dan serapan hara tanaman.
Tipos arquitetônicos e diversidade de usos do solo: uma análise em duas escalas | Architectural types and land use diversity: an analysis in two scales
Authors: Kretzer Geruza , Saboya Renato Tibiriçá
Published: May 2020

As características edilícias são intimamente relacionadas à existência de diferentes usos do solo e, portanto, podem ser determinantes para a promoção da vitalidade urbana. Apesar de alguns estudos existentes apontarem que há uma relação entre características arquitetônicas, uso do solo e diversidade, essa relação ainda deve ser explorada de maneira mais aprofundada. Este artigo investiga as relações existentes entre os tipos arquitetônicos e a diversidade de usos do solo na cidade de Florianópolis (Santa Catarina). Para isso, foram selecionados 65 trechos de vias com auxílio da sintaxe espacial e dados de densidade populacional. Foram levantados dados referentes às características das edificações e usos do solo e, na sequência, os dados foram processados para a elaboração de gráficos de dispersão e diagramas Spacemate, tanto na escala das edificações quanto dos trechos de via. Os resultados obtidos indicam que a posição da garagem fora da parte frontal do térreo das edificações e a alta visibilidade da interface desta com a rua são os fatores mais relevantes para que uma edificação possua mais de um uso. Com relação aos trechos, aqueles com maior diversidade de usos tendem a ter também maior variedade nas suas tipologias edilícias. Também há uma tendência de que trechos que contenham edificações mais próximas às vias, com uma boa densidade de aberturas e alta visibilidade, tenham maior diversidade de usos.
MIGRASI AUSTRONESIA DAN IMPLIKASINYA TERHADAP PERKEMBANGAN BUDAYA DI KEPULAUAN INDONESIA
Authors: Noerwidi Sofwan
Published: May 2020

Abstrak. Pada saat masyarakat penutur bahasa Austronesia datang di Kepulauan Indonesia, kawasanini bukanlah suatu daerah kosong tidak berpenghuni. Beberapa pulau di Kepulauan Indonesia telahdihuni oleh populasi lain. Akibat adanya kontak antar-komunitas tersebut mengakibatkan prosesadaptasi, inovasi, dan interaksi budaya yang khas sebagaimana tercermin pada perkembanganteknologi alat kerang, teknologi pelayaran dan domestikasi hewan yang dikuasai masyarakat penuturbahasa Austronesia. Tahapan proses migrasi masyarakat penutur bahasa Austronesia di KepulauanIndonesia dapat dirangkum sebagai berikut: terjadi intrusi budaya baru di Kepulauan Indonesia yangdibawa oleh Austronesia. Akibat dari peristiwa tersebut, terjadi perkembangan budaya Neolitik diKepulauan Indonesia, disebabkan oleh adaptasi, evolusi dan interaksi antara masyarakat pendatangAustronesia dengan komunitas Non-Austronesia yang telah menghuni kawasan ini sejak masasebelumnya. Interaksi antar-budaya yang intensif menyebabkan integrasi budaya Austronesia danNon-Austronesia di Kepulauan Indonesia. Abstract. Austronesian Migration and Its Implication on Cultural Development in IndonesianArchipelago. When Austronesian language speakers came to Indonesian Archipelago, this regionis not an empty place but had already inhabited by other population. The unique processes ofadaptation, innovation, and culture interaction of Austronesian people in this new region arereflected on the development of shell tool technology, navigation technology, plant cultivation andanimal domestication. In summary, the stages of Austronesian migration in Indonesian Archipelagoare as follows: Intrusion of a new culture that was brought to the Indonesian Archipelago by theAustronesian people, which caused innovation of Neolithic culture in Indonesian Archipelago due tocultural adaptation, evolution, and interaction between the Austronesian speakers (the newcomers)with the indigenous Non-Austronesian communities. Intensive inter-cultural interactions havecreated a cultural integration between the Austronesians and Non-Austronesians in the IndonesianArchipelago.
KONFLIK HORISONTAL WARISAN BUDAYA, MEGALITIK SITUS GUNUNG PADANG
Authors: Sulistyanto Bambang
Published: May 2020

Abstrak. Konflik warisan budaya Situs Gunung Padang merupakan isu baru yang muncul pada 2012, akibat perbedaan dalam memaknai warisan budaya. Bagi kalangan arkeologi, Gunung Padang hanyalah situs megalitik “biasa” yang dikenal dengan istilah punden berundak. Tetapi bagi Tim Terpadu Riset Mandiri, Situs Gunung Padang adalah piramida dan diduga berusia jauh lebih tua dari Piramida Mesir. Konflik horisontal Gunung Padang adalah konflik perbedaan paradigma arkeologi yang berdampak pada perbedaan pandangan dalam menafsirkan keberadaan tinggalan budaya.Konflik tersebut, merupakan konflik murni yang terbatas pada ranah kepentingan Ilmu Pengetahuan tanpa ada intervensi oleh berbagai faktor, termasuk faktor politis. Disisi lain arkeologi sudah lama menjadi ajang pergulatan pemikiran para ahli. Salah satu faktor penyebabnya adalah karena kajian pokok arkeologi bersifat post-facto yang terjadi tidak sekarang, tetapi ratusan bahkan ribuan atau jutaan tahun silam. Pada sisi lain, namanya pengetahuan itu sebenarnya bersifat relatif dan subyektif,karena telah dipengaruhi oleh berbagai kepentingan. Oleh karena itu, pengetahuan yang benar atau realitas masa lampau itu tidak ada, yang ada hanyalah pengetahuan masa lampau versi masyarakat masa kini. Perdebatan dalam ranah ilmu pengetahuan merupakan hal yang biasa. Jika konflik Gunung Padang dapat diselesaikan dengan benar, justru akan memberikan manfaat, salah satunya mendorong ke arah perubahan yang lebih baik. Abstract. Horizontal Conflict Regarding A Cultural Heritage: The Megalithic Site of GunungPadang. Conflict about a cultural heritage, Gunung Padang Site, is a new issue that surfaced in 2012 due to different views in interpreting a cultural heritage. To archaeologists, Gunung Padangis a “typical” megalithic site, which is known as terraced structure. However, to Tim Terpadu Riset Mandiri (Integrated Team of Independent Research), it was a pyramid much older than the ones in Egypt. The horizontal conflict about Gunung Padang is a conflict caused by different archaeological paradigms, which impacted on different views in interpreting the existence of cultural remains. It is apurely conflict, which scope is limited to the domain of Academic purposes with no interventions from various factors, including political factor. Archaeology has long been an arena of debates by experts. One of the reasons is because the main study of archaeology is post-facto – does not happen in recent time, but hundreds and even thousands and millions of years ago. On the other hand, knowledge/science is relative and subjective in nature because it is influenced by various interests. Therefore there is no true knowledge/science or reality of the past. What exists is knowledge about the past according to present-day people. Debates in knowledge/science domain are natural. In fact, if the conflict about Gunung Padang can be resolved in the right way, it will be a benefit, among others it will lead to a change for the better.
Development trends in public reporting during the digitalization
Authors: Malinovskaya N.V.
Published: May 2020

Subject. The article explores the impact of digitalization on the way public reporting of business entities develops.
Objectives. The study reveals the substance of today's trends in the development of public reporting as ICT evolve. I also try raising the public awareness about the XBRL format to submit financial statements and integrated reporting.
Methods. The study relies upon general methods of research, such as the analysis, synthesis, comparison, generalization, abstraction.
Results. The article classifies development trends in public reporting classifying them by scale, inquiry of users, technological means. I determine why such trends arose in terms of technological means. XBRL is found to be a promising format for business data transfer, with difficulties in adopting it being studied by the Russian scholars, who specialize not only in accounting and financial reporting, but also in ICT. I unfold opportunities XBRL gives for sharing and distributing IFRS financial statements electronically. I also evaluate the potential of XBRL for circulating integrated reporting packages among users, though its adoption is impeded due to the non-existent taxonomy of integrated reporting.
Conclusions and Relevance. ICT, modern communication means constructively promote public reporting. XBRL is widely spread internationally to release financial statements electronically, since the IFRS Foundation has outlined the IFRS taxonomy, which is constantly updated and adjusted for IFRS amendments. XBRL presentation of integrated reporting is indispensable without the uniform taxonomy of integrated financial reporting.
The efficiency of the monodirectional economic policy of smaller countries during the globalization and multipolar world
Authors: Chernysheva A.M.
Published: May 2020

Subject. After the collapse of the USSR, smaller countries chose different paths in their economic policy during the globalization and the multipolar world. The EU, USA and Russia made a palpable contribution to the economic policy of smaller countries. Some countries of the former USSR failed to find their course, while the others immediately followed their development strategy and stuck to it persistently. Objectives. I examine the economics of the monodirectional strategy of smaller countries of the former USSR. I also evaluate how the countries found their position among different leading countries as points of attraction. The study is based on the assumption that the single direction of the national development and adherence to the same point of attraction will ensure the sustainable development. However, the economic development level depends on the health of a certain economy as a point of attraction. Methods. The study is based on the systems approach, comparative and statistical methods for analyzing macroeconomic data series. Results. I investigated the dynamics of key macroeconomic data in the Republic of Belarus, Latvia and Estonia, such as GDP per capita in current values, unemployment rate and Purchasing Power Index. Given the current phase of globalization and multipolar world, it is crucial for smaller countries to choose a development strategy to follow persistently and achieve proper macroeconomic indicators that depend on the economic stability of counties they treat as their benchmarks. Conclusions and Relevance. I should mention the successful economic policy of Estonia and Latvia, which followed the same course as the other EU countries, as opposed to the Republic of Belarus tending to the policy of the Russian Federation. Nevertheless, the monodirectional development strategy also helps smaller countries ensure their economic stability.
Medical and demographic particularities of municipalities in the Republic of Karelia
Authors: Molchanova E.V.
Published: May 2020

Subject. This article explores the medical and demographic processes in the Republic of Karelia.
Objectives. The article aims to assess the impact of various factors on regional medical and demographic processes in the context of socio-economic transformation and digital healthcare development.
Methods. For the study, I used a comparative analysis and economic and mathematical methods.
Results. The article reveals demographic features of population resettlement in the Republic of Karelia and patterns of medical and demographic processes in the municipalities of the region. It describes the relationship between socio-economic and medical and demographic indicators, and identifies the benefits and possible risk of introducing modern technologies into real clinical practice.
Conclusions. There are certain man-environment relationships that affect the public health. These relationships need to be taken into account when forming demographic development programmes.
Pengaruh modal manusia terhadap orientasi pasar dan kinerja UMKM
Authors: Syarifah Ina , Mawardi Muhammad Kholid , Iqbal Mohammad
Published: May 2020

Penelitian ini difokuskan pada pelaku UMKM Songkok di Kabupaten Gresik, untuk menguji pengaruh modal manusia terhadap orientasi pasar, pengaruh modal manusia terhadap kinerja UMKM, dan pengaruh orientasi pasar terhadap kinerja UMKM. Penelitian ini mengolah data primer yang diperoleh menggunakan kuesioner yang dibagikan kepada 163 pelaku UMKM. Sampel penelitian dipilih menggunakan metode penyampelan probabilitas dan metode yang digunakan dalam penarikan sampel probabilitas dalam penelitian ini adalah penyampelan klaster. Alat analisis yang digunakan adalah Partial Least Square (PLS). Hasil penelitian menunjukkan bahwa modal manusia berpengaruh terhadap orientasi pasar, modal manusia berpengaruh terhadap kinerja UMKM, dan orientasi pasar berpengaruh terhadap kinerja UMKM.
Analisis migran risen di sektor formal dan informal: Hasil Sakernas 2018
Authors: Amini Ary Fauziah , Sugiharti Lilik , Aditina Neny , Meidika Yefin Amandri
Published: May 2020

Migrasi total penduduk Indonesia mengalami tren peningkatan dalam beberapa kurun waktu terakhir. Pada tahun 1971, dari 100 penduduk enam di antaranya melakukan migrasi, sedangkan di tahun 1990 hampir sepuluh dari 100 penduduk melakukan migrasi. Mayoritas migran melakukan perpindahan dengan alasan mendapatkan pekerjaan. Penelitian ini bertujuan untuk menganalisis keterlibatan migran risen di pasar kerja yang dibedakan ke dalam dua sektor, yaitu sektor formal dan informal. Data yang digunakan adalah Survei Angkatan Kerja Nasional (Sakernas) bulan Februari 2018. Unit observasi dalam penelitian ini adalah penduduk bekerja yang berstatus migran risen. Jumlah unit observasi adalah 2.858 individu yang tersebar di seluruh kabupaten/kota di Indonesia. Metoda analisis yang digunakan adalah regresi logistik biner. Hasil penelitian menunjukkan jika migran risen memiliki peluang lebih tinggi untuk bekerja di sektor formal dibandingkan sektor informal. Karakteristik migran risen yang berpeluang besar memasuki sektor formal adalah: berumur lebih muda, berstatus tidak kawin, berpendidikan menengah dan tinggi, serta pernah mengikuti pelatihan kerja.
Users’ acceptance of financial technology in an emerging market (An empirical study in Indonesia)
Authors: Johan Suwinto
Published: May 2020

This study seeks to investigate the factors that affect consumers’  use of financial technology in fulfilling their financial needs in the emerging market. The financial technology consists of payment gateway, peer to peer lending, online financial product offering, and financial literacy. The paper analyzes five major customers’ aspects, i.e., demography, psychography, banking literacy, technology awareness, and trust of regulatory that consist of 15 variables of customer responses. Those 15 variables explain individuals’ use of financial technology. The binary logit regression technique tests the research models. In the model, consumers’ acceptance (whether one will use financial technology) is operationalized by a dummy variable that equals one if the consumer accepts or is aware of the technology and zero otherwise. The total sample is 298 respondents. The respondents are mostly millennial generation (56 percent), university graduates (76 percent), individuals with the income level of B-Class and A-Class (67 percent), 95 percent of the respondents have bank accounts, and almost 99 percent of the respondents have social media accounts. The empirical results show that millennial-age customers with the income levels of B-Class and A-Class have the highest financial technology acceptance. Gender also influences the acceptance level of financial technology.
Country of origin dan keputusan pembelian konsumen otomotif: Peran nilai terpersepsi sebagai pemediasi
Authors: Handoyo Niko , Nugraha Albert Kriestian Novi Adhi
Published: May 2020

Penelitian ini bertujuan untuk menguji pengaruh country of origin terhadap keputusan pembelian produk otomotif melalui nilai terpersepsi sebagai variabel mediasi. Produk baru yang berasal dari negara dengan stereotif negatif karena pengalaman masa lalu menghadapi tantangan besar untuk dapat memperoleh respon positif dari konsumen. Model struktural diuji untuk memvalidasi apakah   country of origin relevan dalam pengambilan keputusan pembelian konsumen terhadap produk dengan keterlibatan tinggi seperti produk otomotif.  Model struktural berisi variabel eksogen country of origin, variabel mediasi nilai terpersepsi, dan variabel endogen keputusan pembelian konsumen. Responden penelitian dipilih dengan menggunakan metode non-probability sampling dan teknik purposive sampling. Responden adalah sembilan puluh pemilik dan konsumen dari tiga tipe produk otomotif Wuling. yang terlibat dalam survei dengan mengisi kuesioner terstruktur. Alat analisis data menggunakan structural equation modeling partial least squares (SEM-PLS) yang terdiri dari dua tahap: pengujian model pengukuran dan pengujian model struktural. Hasil penelitian menunjukkan bahwa nilai terpersepsi secara parsial memediasi hubungan country of origin dan keputusan pembelian konsumen.
Producing Physicians for Rural Kansas
Authors: Cathcart-Rake William
Published: May 2020

Abstract

            Physician workforce shortages in rural areas are well-documented problems. The University of Kansas School of Medicine (KUSM) established the Salina regional medical campus (RMC) in response to the need to train more physicians interested in primary care in rural Kansas. Since its founding in 2011, thirty-eight students have completed their training on the Salina RMC and received their M.D. Twenty-eight graduates (74%) matched in primary care residencies; eighteen (44%) in family medicine. Eleven of the first sixteen graduates have finished residency and entered practice; nine are in Kansas, and seven of those are in rural Kansas. The Salina RMC has had early success in producing primary care physicians to serve rural Kansas.

 

The author has no conflict of interest to report.
Osteoarticular involvement of brucellosis in pediatric patients: clinical and laboratory characteristics
Authors: Çiftdoğan Dilek Yılmaz , Aslan Selda
Published: May 2020

Background and Objectives. The aim of this study was to evaluate the clinical and laboratory characteristics of osteoarticular involvement in children with brucellosis.
Methods. A total of 202 pediatric brucellosis patients were evaluated from April 2012 to August 2013.
Results. Among the 202 patients, 53 (26.2%) had osteoarticular involvement. In patients with osteoarticular involvement, the mean values of estimated sedimentation rate (ESR) and C-reactive protein (C-RP) were significantly higher than in patients without osteoarticular involvement (p = 0.001, p = 0.01, respectively). The majority of patients with osteoarticular involvement (n = 48, 90.6%) had a higher standard tube agglutination (STA) test titer (≥ 1/640) than patients without osteoarticular involvement (n = 69, 46.3%) (p = 0.001). The most commonly found osteoarticular involvement was peripheral arthritis. The second most commonly found osteoarticular involvement was sacroiliitis (n = 5, 9.4%). Three patients (5.7%) had spondylitis. Only one patient (1.9%) had osteomyelitis.
Conclusions. Osteoarticular involvement was detected in nearly one of every four childhood brucellosis patients in our study. Brucellosis should be considered as a pre-diagnosis in children with osteoarticular complaints, especially in regions where the disease is endemic.
Increased potassium excretion in children with monosymptomatic nocturnal enuresis: could it be related to Kir 4.1- KCNJ10 gene polymorphism?
Authors: Balat Ayşe , Parlak Mesut , Balcı Sibel Oğuzkan , Göğebakan Bülent , Büyükçelik Mithat , Çöl Nilgün , Kul Seval , Tınaztepe Keriman
Published: May 2020

Background and Objectives. There are controversial results in the literature regarding urinary electrolytes, especially potassium, in enuretic children. KCNJ10 channel protein, a member of the Kir 4.1 family is expressed in renal distal tubules and has an important function in renal ion transport. We investigated whether KCNJ10 gene polymorphisms are associated with clinical and laboratory findings of a group of Turkish children with monosymptomatic primary nocturnal enuresis (MNE).
Method. Ninety-seven MNE children and 100 healthy controls were tested for three single nucleotide polymorphisms (SNPs) in the KCNJ10 gene. The transversions in SNPs were G to A for intron 1(SNP1), G to A for exon 2 (SNP2), and T to C transition for promoter (SNP3). All SNPs were genotyped by PCR-restriction fragment length polymorphism.
Results. SNP3 in promoter of KCNJ10 gene showed strong association with MNE children for distribution of genotype and allele frequency, while SNP1 in intron 1 and SNP2 in exon 2 were noninformative. The distribution of TT, TC, and CC genotypes for SNP3 was 66%, 26.8% and 7.2% respectively in MNE compared with 38%, 59% and 3% respectively in controls (p < 0.0001). In enuretic children, TT genotype was higher and there was an increased potassium excretion in children with TT genotype (P < 0.05).
Conclusion. We conclude that KCNJ10 gene promoter polymorphism may have a role on potassium excretion in Turkish MNE children. This is the first study in literature evaluating KCNJ10 gene polymorphism in this patient population. Future studies investigating the other SNPs, mutations or altered regulation of Kir4.1 in larger samples would help clarify the role (s) of KCNJ10 gene in enuresis.
Clinical manifestation and outcomes of children with hypertrophic cardiomyopathy in Kosovo
Authors: Bejiqi Ramush A , Retkoceri Ragip , Zeka Naim , Vuçiterna Armend , Mustafa Aferdita , Maloku Arlinda , Bejiqi Rinor
Published: May 2020

Background and Objectives. Identification of the manifestations, assessment and follow up of children with hypertrophic cardiomyopathy (HCM) by transthoracic echocardiography may be important for clinical management and our understanding of pathogenesis.
Methods. We present a comprehensive analysis of 43 children seen in Kosovo, 23 were male, aged between 4 months and 9 years at first presentation (median of 2 years and 3 months).
Results. Cardiac failure, seen in almost half of them, was the most common presenting feature. At admission, the chest x-ray revealed an increased cardiothoracic ratio, to a mean of 72% in 6 infants and to 65% in 37 older children. Measured by transthoracic echocardiography, 28 children had asymmetric hypertrophy of left ventricle while 15 had concentric hypertrophy. Left ventricular ejection fraction was depressed in 21 children. Patients with cardiac failure received various combinations of diuretics, B-blockers, ACE inhibitors and anticoagulant therapy (aspirin). Death occurred in 8 children, in 4 of them shortly after admission, the other 4 left Kosovo and continued examination and treatment abroad Kosovo; their death has been confirmed by family members. The remaining 32 were followed- up for a mean 42 months, with a range from 5 to 115 months. Surgical intervention was not performed to any of them, despite the clinical and echocardiography indications due to a limitation of resources. Recovery was noted in 14 children but still requiring anti-heart failure medications. Slightly over two-fifths died. Of those with asymmetric form, 45% died, half of those presenting in infancy, and 89% of those who presented at admission with signs of cardiac failure.
Conclusion. The results of our study show that similar to many centers, the etiology of HCM is often uncertain. In the absence of etiology, treatment aimed at the cause is either impossible or, at best, empirical.
The corrected QT interval prolongation in adolescents with cardiac iron overload β-thalassemia major
Authors: Advani Najib , Kautsar Ahmad , Andriastuti Murti
Published: May 2020

Background and Objectives. Iron-induced cardiomyopathy remains the leading cause of mortality in β-thalassemia major patients. The T2* magnetic resonance imaging (MRI) technique is the gold standard for iron load detection, yet it is expensive and not widely available especially in the developing countries. Some previous studies showed that QTc interval could be used as an early detection of cardiac iron overload. This study aimed to evaluate the diagnostic value of QTc interval as a marker of early detection of cardiac iron overload in adolescent beta thalassemia major patients.
Methods. We prospectively evaluated electrocardiography (ECG) parameter of QTc interval in 50 β-thalassemia major patients aged 10-18 years. All participants had a 12-lead ECG evaluation, echocardiogram and cardiac MRI T2* examination within three months (average 15 days). They were categorized as cardiac iron overload (MRI T2* < 20 millisecond) and non-cardiac iron overload (MRI T2* > 20 millisecond).
Results. Of the 50 patients, the male to female ratio was 1.08:1 and the mean age was 13.7 ± 2.43 years. All participants showed normal systolic and diastolic function using conventional echocardiography. The mean QTc interval was significantly different between cardiac iron overload group (464.44 ± 20.35 ms) and noncardiac iron overload group (431.09 ± 32.29) (p= 0.001). Diagnostic study of QTc interval resulted in AUC 0.8 (p= 0.002). Calculated sensitivity and specificity of QTc interval were 0.88 and 0.73 respectively, with cut-off point of 449 ms.
Conclusion. Cardiac iron overload is associated with QTc prolongation in adolescents. QTc interval of 449 ms could be considered as a cut-off point of cardiac iron overload.
Tetanus; a forgotten infection disease: a report of two cases
Authors: Barlas Ülkem Koçoğlu , Kıhtır Hasan Serdar , Yeşilbaş Osman , Petmezci Mey Talip , Akçay Nihal , Petmezci Ercüment , Hatipoğlu Nevin , Şevketoğlu Esra
Published: May 2020

Background. Tetanus is an infectious disease that can be seen in all age groups in underdeveloped and developing countries, where vaccination programs are inadequate. In developed countries, it is reported more frequently in the adult age group, where the protection of vaccination is diminished and the doses are delayed.
Case. In this report, we present generalized tetanus, which was observed in two male patients aged 12 and 6 years, admitted at different times, together with clinical course and treatment approaches. Both patients belong to different nationalities, who immigrated a couple of months before their application to our hospital. They applied with similar histories and complaints and were not vaccinated during infancy.
Conclusion. With the development of vaccination programs, this disease with high morbidity and mortality can be prevented.
Congenital afibrinogenemia in a 4-year-old girl complicated with acute lymphoblastic leukemia
Authors: Özcan Alper , Samur Bahadır , Akyol Şefika , Erdoğmuş Necdet Arda , Patıroğlu Türkan , Karakükçü Musa , Ünal Ekrem
Published: May 2020

Background. Congenital fibrinogen deficiency is one of the rare inherited coagulation disorders. Congenital fibrinogen deficiency complicated with a hematological malignancy can be life threatening.
Case. We present a four-year-old girl with congenital fibrinogen deficiency complicated with acute lymphoblastic leukemia.
Conclusion. This case aims to highlight therapeutic approaches for the management of afibrinogenemia patients with acute leukemia.
Kawasaki disease presented with status epilepticus and diffusion MRI abnormalities in the subcortical white matter
Authors: Keino Dai , Koto Yuki , Inuo Chisato
Published: May 2020

Background. Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and young children. Encephalitis/encephalopathy is an extremely rare complication of KD.
Case. A previously healthy 8-month-old Japanese boy had a prolonged seizure after febrile illness for one day. On the fourth day, he had bilateral nonexudative conjunctivitis, changes in the extremities, rash and induration at the Bacillus Calmette-Guerin inoculation site. He was diagnosed with incomplete KD and treated with immunoglobulin. On the fifth day, he had cluster seizures. Brain magnetic resonance imaging (MRI) showed restricted diffusion in the left subcortical white matter, which was consistent with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). He was treated with controlled normothermia, pulseddose methylprednisolone, continuous infusion of midazolam, and edaravone. On the tenth day, he had a recurrent fever and was treated with a second course of immunoglobulin. Subsequently, he had defervescence, and the abnormal signal detected in the MRI disappeared. At the age of 11 months, he had normal growth and development for his age by the Denver Developmental Screening Test.
Conclusion. It is necessary to consider AESD as the differential diagnosis of prolonged seizure in infants with KD. Brain MRI led to early diagnosis and intervention in our patient. The neurological prognosis of our patient was relatively good, but the prognosis of KD with AESD is unknown. To clarify this, further case accumulation is warranted.
Maternal and fetal tuberous sclerosis complex: a case report questioning clinical approach
Authors: Onay Özge Sürmeli , Sağlık Adviye Çakıl , Köşger Pelin , Saraçoğlu Zeynep Nurhan , Toprak Uğur , Uçar Birsen , Tekin Ayşe Neslihan
Published: May 2020

Background. Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease with multisystem involvement.
Case. Here, a mother and infant couple was presented with maternal and fetal TSC including demonstrative clinical findings and genetic analysis. The interesting point of this case report is that maternal and fetal TSC was identified after the mother gave birth to a child with a cardiac rhabdomyoma. The genetic analysis revealed a novel mutation which was the same in both the mother and her infant.
Conclusion. We would like to bring to the attention of clinicians this entity and to emphasize that maternal and fetal TSC can adversely affect maternal and fetal health, and deserves close follow up. Our recommendation is that if cardiac rhabdomyoma/cortical tuber/renal angiomyolipoma are present in prenatal ultrasonography, the parents should be evaluated for TSC.
Pediatric case of persistent hiccups associated with hypertrophic olivary degeneration
Authors: Arıcan Pınar , Öztekin Özgür , Çavuşoğlu Dilek , Yılmaz Sema Bozkaya , Ersen Atilla , Dündar Nihal Olgaç , Gençpınar Pınar
Published: May 2020

Background. Hypertrophic olivary degeneration (HOD) is a rare degenerative disorder that is thought to occur subsequent to a disruption of the dentate-rubro-olivary pathway.
Case. We report a pediatric case of unilateral HOD presented with persistent hiccups and palatal tremor. Radiological examination of diaphragm was normal considering ultrasound and chest x-ray. On T2WI (weighted images) and Fluid Attenuated Inversion Recovery (FLAIR) images, hyperintense enlargement of the right inferior olivary nucleus was seen. No abnormal enhancement was detected on post-contrast scans and no evidence of restricted diffusion was seen. Susceptibility weighted imaging (SWI) sequences revealed a chronic hemorrhage involving the medulla oblongata and cerebellum. Cranial magnetic resonance imaging (MRI) findings were consistent with unilateral HOD. Palatal tremor and dentate-rubral tremor are frequent presentation of HOD, however to our knowledge persistent hiccups had not yet been reported in children with HOD.
Conclusion. We highlight a pediatric case of unilateral HOD, which presented with persistent hiccups. Awareness of clinical and radiological findings of HOD is important to avoid misinterpretation as a mass lesion, an ischemic event, or a demyelinating disease and provide adequate management.
Analisis Kinerja Operasional Kereta Api Pangrango Bogor – Sukabumi
Authors: Saputra Dika , Osly Prima Jiwa , Meutia Wita
Published: May 2020

Kota Bogor dan Kota Sukabumi dua wilayah penting di Jawa Barat yang memiliki hubungan erat satu sama lain. Sehingga terdapat kebutuhan pergerakan yang besar pada kedua wilayah tersebut. Keterbuhungan antar kedua wilayah tersebut, difasilitasi oleh kereta api Pangrango Bogor – Sukabumi. Kereta api Pangrago yang diresmikan pada November 9, 2013 diharapkan dapat membantu memenuhi kebutuhan pergerakan pada kedua wilayah tersebut. Kereta api Pangrango digunakan untuk perjalanan kerja, berdagang maupun berlibur.. Maksud dari tujuan penelitian ini adalah untuk mengidentifikasi waktu henti dan waktu tempuh serta menganalisa kenyamanan kereta api Pangrango Bogor – Sukabumi. Metode pengumpulan data dalam penelitian ini menggunakan survei kinerja dan wawancara. Analisis yang digunakan adalah analisa jumlah responden dan analisis metode Importance Performance Analysis (IPA). Hasil dari kinerja rata – rata waktu tempuh dari stasiun Bogor Paledang – Sukabumi selama suvei sebesar121 menit dan hasilnya sama sesuai GAPEKA 2017 yaitu 121 menit. Rata – rata waktu tempuh dari stasiun Sukabumi – Bogor Paledang selama survei sebesar 122.66 dan hasilnya hampir mendekati GAPEKA 2017 yaitu 123 menit. Rata – rata waktu henti dari stasiun Bogor Paledang – Sukabumi selama survei sebesar 23 menit dan hasilnya sesuai GAPEKA 2017 yaitu 23 menit. Rata – rata waktu henti dari stasiun Sukabumi – Bogor Paledang selama survei sebesar 23 menit dan hasilnya sesuai GAPEKA 2017 yaitu 23 menit. Hasil dari metode Importance Performance Analysis (IPA) diperoleh rata – rata nilai tingkat kepuasan dan kepentingan dari keseluruhan atribut pelayanan kereta api Pangrango Bogor Paledang – Sukabumi sebesar6603 dan 8275. Dengan nilai kesesuain sebesar 79.79%. Dari hasil GAP ANALYSIS (kesenjangan) didapatkan nilai rata – rata dibawah 0, berarti atribut – atribut yang sudah tertera di kuersioner belum memenuhi harapan para pengguna kereta Api Pangrango Bogor – Sukabumi.
PENGARUH MODEL PROJECT BASED LEARNING (PjBL) PADA KONSEP SISTEM KOORDINASI MANUSIA TERHADAP KETERAMPILAN METAKOGNITIF SISWA KELAS XI SMA NEGERI 4 BANJARMASIN
Authors: Mahfuzah Aulia , Ramdiah Siti
Published: May 2020

Quality education is needed to support the creation of intelligent people who are able to compete in the era of globalization. However, based on a number of international, national, to regional assessments and facts that are encountered directly in the field, students provide information that student awareness in learning is still lacking. This information shows that the cognitive learning outcomes of students have not been maximized. This study aims to determine the effect of the PjBL model on the metacognitive skills of the XI MIPA grade students of SMA Negeri 4 Banjarmasin. Metacognitive skills can help students develop thinking skills which further influence student learning outcomes. This type of research is a quasi experiment, with a design model known as non equivalent pretest-posttest control group design. Data collection techniques using essay tests. Assessment of metacognitive skills refers to Corebima (2009). The research data were analyzed by one way ANOVA statistical analysis using SPSS version 24 for windows with a significance level of 5%. The results showed the average value of the experimental class students facilitated by the PjBL model by 85.47 and the control class facilitated by conventional learning by 73.41 with Fcount = 17.616 (p = 0.000 <0.05). Thus, it can be concluded that the Project Based Learning model has a significant positive effect on the metacognitive skills of the 11th grade students of Mathematics and Natural Sciences in SMA Negeri 4 Banjarmasin
Leadership Under Islamic Norms (Al Imamah fill Islam)
Authors: Rifai Moh.
Published: May 2020

Based on the expert opinions, a leadership was a governance which carried out by someone (individual) including institutions based on deliberation that gave a consensus decisions in the form of right and obligation which must be done as the mandate. Another argument said that a leadership was a society servants (al imamu huwa ngabdu qoumin). In fact, the country that was not Islamic state (under Islamic norms) there was different meaning of a leadership here. A leader would develop based on the basic foundations (norms) of each countries including have different patterns which be expanded by each government systems of its country. For the example, the Republic of Indonesia which embraced Presidential systems with Trias politica models (The typical division is into three branches: a legislature, an executive, and a judiciary) that have its primary tasks and functions. When these branches were not harmonious, it would made imbalance nuances and mutual suspicion among the government institutions.

 
Pharmacological, bioactive screening of medicinal plant Nigella sativa and the derived compound thymoquinone : An invitro study
Authors: Sandhya A  , Gomathi Kannayiram
Published: May 2020

The richest biosource of drugs are from the medicinal plants which are the traditional medicine. The nutraceuticals, food supplements, Siddha, Ayurveda, pharamceutical medicines, synthetic drugs are from the plant sources. Inspite of large number of studies with herbal plants which have given good correlation in the phytochemical, anti-diabetic and anti-inflammatory content, Nigella sativa- a spice plant of Ranunculacea family showed significant properties than their counterparts. The seeds of Nigella sativa and the essential oil were found to exhibit various pharmacological activities like antianalgesic, antiulcer, anti-inflammatory, antibacterial, antimicrobial, anticancer and anti-diabetic. Since there are no toxic effects or serious side effects observed using animal model and in the clinical trials, the study was carried out using Nigella sativa and Thymoquinone to find out the qualitative and quantitative phytochemical analysis, invitro - anti diabetic activity, anti inflammatory activity of Nigella sativa ethanolic extract and Thymoquinone effect on diabetes and Alzheimer’s disease. The aim of the study is to prove that the Nigella sativa could be used as therapeutic agent and the compound Thymoquinone a potential cholienesterase inhibitor for the treatment of Alzheimer’s disease.
A Review on Chiral Columns/Stationary Phases for HPLC
Authors: Suraj Koorpet R  , Akshay N  , Nishanth G  , Chandan R S  , Anand Kumar Tengli
Published: May 2020

The chiral separation of pharmaceutical molecules and their precursors is one of the important areas of application of HPLC in pharmaceutical analysis for obtaining enantiomerically pure drug. The latter procedures include the use of so-called chiral selectors to enantio-selectively recognise and isolate the enantiomer. The direct approaches, i.e. those which do not derivate the compound of interest before separation, are addressed in detail, since they are now the most common approaches. The role of stereochemistry in medicinal products is being given greater emphasis to medical practice. For physicians to make conscious choice about the use of single-enantiomered medicinal products, basic knowledge is required. For few treatments single-enantiomer formulations can provide more selectivity than a combination of enantiomers in their biological purposes, enhanced therapeutic indexes and/or better pharmacokinetics. This highlights the possible biological and pharmacological variations between the two drug enantiomers and underlines the clinical experience of individual enantiomers. Particular emphases have been put on chiral separation by HPLC on chiral stationary phases (CSPs). Chiral derivatization reagents (CDRs) are optically pure reagent on reaction with drugs forms a pair of diastereoisomers that can be separated on conventional achiral phase.  In Chiral mobile phase additive (CMPA) method, the stationary phase is achiral and the chiral selector is dissolved during the mobile phase. Interaction with the analyte’s enantiomer leads to the formation of transient diastereomeric complexes that are separated by their affinity towards mobile/stationary phase. Separation mechanisms and method development for chiral molecules using these phases are discussed in this review.
Learning Mole Concept with PALS: An Intervention for Working Students in a Night School
Authors: Taborada Jeniffer C. , Sanchez Joje Mar P.
Published: May 2020

A quasi-experimental study was done in order to investigate the effectiveness of Peer-Assisted Learning Strategy (PALS) as an intervention in learning Mole Concept for the ninth grade-working students in a night school in Cebu City, Philippines. Study findings revealed that students exposed to conventional lecture method (CLM) (N=15) had Below Average performance in the pre/posttests, and those exposed to PALS (N=15) had Below Average performance in the pretest and Average performance in the posttest. Both groups had significant mean improvement before and after exposure to CLM (t=5.07, p=.000) and PALS (t=10.37, p=.000), indicating that both lectures and peer tutoring are essential in teaching-learning process. The study also found out that those exposed to PALS (t=4.24, p=.000) had significantly greater improvement than those exposed to CLM. Moreover, sex, age, civil status and number of people in the house were not associated with their performance in Chemistry, implying that these profiles do not affect the tutor-tutee relationship. The study concluded that PALS manifested a more enhanced performance among the working students in Chemistry.