bluuebunny/crossref_metadata_2025 huggingface dataset:
УПРАВЛІННЯ ЗНАННЯМИ В ЗАКЛАДАХ ОХОРОНИ ЗДОРОВ’Я
Authors: Білошицька Оксана , Зюков Олег
Published: April 2023

Знання є основним ресурсом в будь-якій організації. Концепція управління знаннями досить поширена в бізнес-секторі вже давно. Але лише нещодавно управління знаннями привернуло увагу сектору охорони здоров’я, частково через постійно зростаючий обсяг інформації, з якою повинні працювати медичні працівники. Важливо мати спосіб керування інформацією, що надходить до організації охорони здоров’я та виходить із неї. Сектор охорони здоров'я займає найкраще місце серед інших, маючи неймовірні можливості для розробки, впровадження (та оцінки) систем управління знаннями. Основний аргумент базується на припущенні, що медицина є професією, що базується на знаннях, і що пошук, обмін та розвиток знань медичних працівників є необхідним для ефективної роботи. Якщо заклади охорони здоров’я здатні ефективно управляти своїми ресурсами знань, то відбувається покращення корпоративної ефективності, результативності, впровадження інновацій та підвищення якості надання медичної допомоги пацієнтам. Мета цієї статті полягала в узагальненні попередніх досліджень, конкретних інструментів управління знаннями, з метою виокремлення ключових моментів, які можна було б застосувати в галузі охорони здоров’я. Було проведено систематичний пошук літератури в міжнародних базах даних, відібрані рецензовані статті, які описували ключові елементи процесу управління знаннями та які піддались структурному контент-аналізу.
Ключові слова: охорона здоров’я, обмін знаннями, процес управління знаннями
ДОСЯГНЕННЯ Й АКТУАЛЬНІ ЗАВДАННЯ БІОМАТЕРІАЛОЗНАВСТВА ЯК ПЕРСПЕКТИВНОЇ ГАЛУЗІ БІОМЕДИЧНОЇ ІНЖЕНЕРІЇ В УКРАЇНІ
Authors: Головко Микола , Архирей Марина
Published: April 2023

З використанням бібліометричного аналізу оприлюднених  у Національному депозитарії академічних текстів результатів наукових досліджень з біомедичної інженерії, що виконуються в 2017–2022 р.р. в установах Національної академії наук України та провідних вітчизняних університетах, здійснено огляд здобутків, узагальнено особливості  організації, основні напрями та перспективи подальшої розбудови цієї галузі сучасних біотехнологій. Показано, що  одним із пріоритетів вітчизняної біомедичної інженерії є  біоматеріалознавство, що зумовлено значними потребами у новітніх матеріалів для реконструктивної хірургії, які зростають в умовах воєнного часу. Проаналізовано теоретичні та практичні здобутки нуково-дослідних установ НАН України як потужного інтегрального центру розв’язання актуальних проблем створення та використання сучасних біотехнологій на основі  досягнень  біології, фізики, хімії, матеріалознавства, генетики, медицини. Проаналізовано здобутки університетської науки з  біоматеріалознавства та наголошено щодо її важливої ролі у формуванні нового покоління дослідників-фахівців у галузі біомедичної інженерії. Акцентовано увагу на зростанні значення прикладних досліджень, результатом яких будуть технології створення та використання новітніх біоматеріалів. Визначено необхідність удосконалення та оновлення лабораторної бази підготовки майбутніх фахівців з біомедичної інженеріїв, доцільність більш тісної інтеграції університетської та академічної науки як умови  раціонально використовувати інтелектуальних і  матеріальних ресурсів, задля отримання нових наукових результатів та включення студентської молоді в сучасний науково-дослідницький простір, врахування європейського досвіду організації досліджень шляхом створення  науково-дослідних містечок, парків, кластерів, стартапів.

Ключові слова –  біомедична інженерія, біосумісні матеріали,  академічна та університетська наука в Україні,  перспективи  розвитку.
Republic of Abkhazia: Results of 2022
Authors: Novikov V. , Skakov A.
Published: April 2023

The main domestic political event of 2022 for the Republic of Abkhazia was the parliamentary elections held on March 12 and 26. It’s indicative that only 7 deputies (out of 35) of the previous convocation were re-elected. At least 23 members of the new parliament can be considered pro-government. The opposition is fragmented, but the pro-government forces cannot be considered united. The request for the formation of a “third force” isn’t satisfied. Crisis phenomena in the socio-political and economic spheres continue to have a destabilizing effect on the situation in the republic, some positive changes and implemented projects don’t have a decisive impact. Domestic political stability and the sustainability of the existing system of power remain vulnerable.
Migration Flows from Central Asian Countries: New Challenges and Opportunities
Authors: Maslanov K. , Tarasova D.
Published: April 2023

The article is devoted to the transformation of migration flows from Central Asian countries, the associated difficulties and new opportunities. The recession in the Russian economy, following the pandemic and the events in Ukraine, forces countries that depend on it as a host country and accordingly on remittances from abroad to look for new sources of income to support their economies. At the moment, this process is still heterogeneous and complex, both for new receiving countries and for countries of origin, but countries lacking workers are ready to adapt their legislation to changing realities.
Pension Systems of Central Asian States
Authors: Syndyashkina E.
Published: April 2023

Orientation towards the formation of the Eurasian socio-economic space implies the coordination of social policy, including in the field of pension provision. The harmonization of pension systems involves an analysis of the conditions for the formation and main parameters, the identification of common features and differences, and the determination of development prospects. The key problems of pension systems in the countries of Central Asia are the limited coverage of working people with pension insurance combined with a low basis for calculating pension contributions. The demographic factor plays a dual role in the functioning of pension systems. The countries of the region are characterized by a low proportion of older populations coupled with high rates of aging. At the present stage this can be seen as a demographic bonus, but in the long term it will become a serious challenge for the sustainability of pension systems. The situation is aggravated by the high migration outflow of the able-bodied population. One of the ways to increase the stability of pension systems can be to increase the role of state pensions – the development of the state system of social protection of pensioners as the main link in the pension system supplemented by private insurance and funded payments.
RAINER FORST: UM DISCÍPULO DA TEORIA CRÍTICA?
Authors: Reis Patrícia Carvalho
Published: April 2023

Neste artigo, gostaríamos de refletir os pontos de contato entre a reflexão de Rainer Forst sobre a justiça e a Teoria Crítica. Para isso, primeiramente, investigaremos os traços fundamentais desta teoria assim como mostraremos em que ela se distingue da Teoria Tradicional. Após, exporemos a concepção de justiça em Rainer Forst. Num momento posterior, apresentaremos nossa visão sobre a possibilidade de considerar Rainer Forst como um teórico crítico.

Palavras-chave: Rainer Forst. Justiça. Teoria Crítica. Liberalismo. Comunitarismo.
O IMPACTO DA PSICANÁLISE NA TRANSFIGURAÇÃO DA TEORIA CRÍTICA
Authors: Drawin Carlos Roberto
Published: April 2023

O presente texto divide-se em três partes. Na primeira abordamos uma problemática de fundo da Teoria Crítica de modo a propor a flexibilização de suas fronteiras no sentido da abertura transdisciplinar e da incorporação de pensadores que normalmente não são incluídos em sua tradição. Nesse quadro teórico mais amplo se daria o seu encontro com a psicanálise. Na segunda parte caracterizamos alguns elementos desse encontro apontando as suas dificuldades e tomando as ideias de Wilhelm Reich como um caso exemplar dessas dificuldades enquanto tentativa de uma síntese freudiana-marxista. Na terceira parte propomos a polarização das duas correntes de pensamento como uma forma de manutenção de seu potencial crítico.

Palavras-chave: Teoria Crítica. Marxismo. Psicanálise. Humanismo. Naturalismo. Pulsão. Emancipação.
Analysing the Shahr-i Sokhta Board Game and Suggested Rules
Authors: Jelveh Sam , Moradi Hossein
Published: April 2023

In the archaeology of western Asia, scholars have focused on Susa and Mesopotamia in the west and theIndus Valley and southeast of Iran to the east for interpreting of the existence of intercultural goods. Suchroad enabled contacts between the people in its trans-regional form, allowing the transference of beliefsand ideologies across this long trade road. Among all these exchanged goods between east and west, thegame boards from Shahr i Sokhta in Sistan in southeast of Iran and Ur in Mesopotamia are unique due tothe absence of older types and the presence of their ideas in the modern world. This paper focuses onstudying the game board set from the Bronze Age site of Shahr-i Sokhta, found at grave no.731 of thegraveyard of the site. It analyses the different pieces and outlines the reasons behind the proposed gamestrategy and rules, based on the game’s theoretical and available archaeological evidence. The studyunveils the meaning of one of the mysteries of the game pieces, and it can change our understanding of theboard games discovered in Near East. This study focuses on a new proposed rule to introduce aplayable set and to identify and analyse all the discovered pieces and dice. This research can also help torefine the rules and open an opportunity for discussion around this set of board games in future studies.The suggested game rules attempt to be familiar to the time and bring meaning to each part of the game board.
Mineral-Solubilizing Microbial Inoculums Promote Robinia pseudoacacia L. Growth by Optimizing the Rhizosphere Soil Microbial Community Structure
Authors: Zhang Jingchi , Jia Zhaohui , Li Chong , Ma Shilin , Liu Xin , Meng Miaojing , Cheng Xuefei , Nie Hui
Published: April 2023

The addition of mineral-solubilizing microbial inoculums is a kind of biological measure for vegetation restoration of rock mining areas. Its function is to accelerate soil weathering, improve soil fertility, improve the ability of plants to fix soil. Through understanding the response of plant rhizosphere microbial community to the mineral-solubilizing microbial inoculums, it is helpful to popularize the use of mineral-solubilizing microbial inoculums. However, little is known about the changes of plant rhizosphere soil microbial communities after the addition of mineral-solubilizing microbial inoculums. Therefore, the purpose of this study was to reveal the pasthways through which different mineral-solubilizing microbial inoculums positively affect underground part of R. pseudoacacia. A pot experiment was conducted to investigate the responses of rhizosphere soil bacterial and fungal communities in R. pseudoacacia by taking 32 samples from four different mineral-solubilizing microbial inoculums treatments. The results showed that the effect of mineral-solubilizing microbial inoculums on the structure of fungal community was greater than that of bacterial community. But the relative abundance of Proteobacteria was increased, which had a strong positive correlation with root nodulation. In terms of microbial diversity, mineral-solubilizing microbial inoculums had a greater effect on the diversity and evenness of bacterial community. It is worth noting that correlation analysis showed that Proteobacteria and Verrucomicrobia in bacteria and Ascomycota and Zoopagomycota in fungi were positively correlated with soil enzyme activity and plant growth. RDA analysis showed that the relative abundance of these two phyla in bacteria also had positive effects on plant root nodulation. Our results showed that the addition of mineral-solubilizing microbial inoculums can optimize the rhizosphere soil microbial community structure, promote R. pseudoacacia root nodulation, and enhance the nitrogen fixation capacity of plants. In addition, this study can provide a theoretical basis for the application of mineral-solubilizing microbial inoculums to a wide range of slope ecological restoration.
Reactive power optimization in distribution systems considering load levels for economic benefit maximization
Authors: Srinivasan G. , Mahesh Kumar Reddy V. , Venkatesh P. , Parimalasundar E.
Published: April 2023

Introduction. The need for electrical energy has been increased sharply due to hasty growth in industrials, social and economic improvements. From the previous studies, it has been agreed that almost 13 % of the total power generated is wasted as heat loss at distribution level. It has been extensively recognized that the node voltage profile along the distribution system can be enhanced under steady state power transfer controlled by proper reactive power compensation. Capacitors have been acknowledged as reactive power compensating device in distribution systems to achieve technical and economical benefits. Novelty of this work is the application of Archimedes optimization algorithm for reactive power optimization in distribution systems so as to obtain an improved solution and also a real 94-bus Portuguese network and modified 12-bus network has been taken and validated for three different load levels which are totally new. Purpose of the proposed work is to maximize the economic benefit by reducing the power loss and capacitor purchase cost at three different load conditions subject to satisfaction of equality and inequality constraints. Methods. The economic benefit has been validated using Archimedes optimization algorithm for three load levels considering three distribution systems. Results. The computational outcomes indicated the competence of the proposed methodology in comparison with the previously published works in power loss minimization, bus voltage enhancement and more economical benefit and proved that the proposed methodology performs well compared to other methods in the literature.
Technology Focus: Artificial Lift (March 2023)
Authors: Harris Dennis
Published: April 2023

Selecting artificial lift papers for the Tech Focus feature of JPT can be a daunting exercise when technologies and innovations abound, more so post-pandemic, with 157 submitted abstracts covering 2021–2022. In narrowing the offerings to three, the criteria of conformance to guidelines and novelty of information, technical equipment, and application were considered. Industry indicators and interest were also factors.

Gas lift remains of high global interest, whether in long horizontal shale oil wells or vertical ones because of the cost to operate lower lifting. Declining production and high gas/oil ratios (GORs) present a challenge for conversion to secondary lift forms. Paper SPE 209721 provides an innovative solution combining gas lift with sucker rod lift to enhance and exploit low-productivity wells in high-GOR fields.

Permanent magnet motors (PMMs) have made quite the technical splash in the industry over the past decade. PMMs are one-third shorter and result in higher power densities and power savings of up to 18% just by changing out the induction motor. PMMs are again grabbing attention for the direct 1:1 ratio of electrical to carbon footprint. Current environmental, social, and governance concerns are placing demands on all operators, and PMMs are positioned to help with carbon reduction as a low-hanging fruit in paper SPE 209736.

In paper SPE 209763, we look at all-metal progressing cavity pumps (aka M2M), which consist of a metal rotor and metal stator. Incremental advances in geometry and materials continue to see operators use high-temperature fluids with low operational expenditure in mind. Reliability is always a concern, and now a novel condition indicator has been developed and tested that offers a better indicator than pump efficiency alone.

Recommended additional reading at OnePetro: www.onepetro.org.

SPE 206909 Successful Progressing Cavity Pump Reliability Improvement Project in an Oman Steamflood by Shauna Noonan, Oxy, et al.

SPE 211782 Maximizing Marginal Fields Profitability Through Drilling Multilateral Wells To Reduce Well Count and Well Cost: Dual Lateral Well With Single ESP and Smart Lower Completion by Mahmoud Mohamed Abdelhay Mostafa, ADNOC, et al.

SPE 209748 Gas Pump—A Gas-Driven Positive Displacement Pump Artificial Lift System by Stephen W. Turk, ELC Energy Services, et al.
Technology Focus: High Pressure/High Temperature (March 2023)
Authors: Das Santanu
Published: April 2023

The array of papers received for review this year covers a wide spectrum, both in applications and research, which indicates that the exploration and production (E&P) industry is actively working to monetize high-pressure/high-temperature (HP/HT) reservoirs.

The pandemic has already put an indelible mark on the industry during the past 2 years. The present geopolitical scenario is posing a serious challenge to countries’ energy security. The oil and gas sector is confronted with the biggest task in society—addressing climate change.

The E&P sector is going to face stiff challenges in the coming days, with the word “petroleum” being substituted by the word “energy” to cover wider possibilities. Eminent actions are distinctly visible in the strategic planning of fossil fuel companies and the capital-expenditure investments in the E&P sector. Companies are shifting priorities toward diversification, resilience, and decarbonization.

Safety continues to dominate HP/HT operations and will do so in the future with more-stringent measures and compliances. Cost-effective technology solutions blanketing the entire domain of HP/HT activities will provide exploitation on a sustainable basis with collaboration between industry and academia.

While reviewing the papers, every attempt was made to provide a fair representation that cuts across the HP/HT domain to show the reader what is happening in the industry, both in the field as well as in research, over different geographical locations. Several of these case studies presented inspiration tied to the indomitable human spirit that can overcome challenges through innovation.

Recommended additional reading at OnePetro: www.onepetro.org.

SPE 210702 An Integrated Approach in Pore-Pressure Prediction Contributes to Drilling Success of an HP/HT Wildcat Well in the South China Sea by Lijun Guan, CNOOC, et al.

SPE 209865 Challenges of an HP/HT Completion Design With Extreme H2S and CO2 in a Carbonate Gas Development by C.W. Graham Grant, PTT Exploration and Production, et al.

OTC 31051HP/HT Subsea Connector Verification and Validation Using an API 17TR8 Methodology by Barry Stewart, TechnipFMC, et al.

SPE 210543 Bridging the Gap: Highly Depleted Reservoir Entry in a Mature HP/HT Field by Michael Cadd, Shell, et al.

SPE 211735 Innovative Solutions to Subsurface Challenges in Deep Hard-Rock High-Temperature Slim Wells by Khalifa Omair Wahshi, Petroleum Development Oman, et al.
Clinical Results and Review of Techniques of Thoracic Endoscopic Unilateral Laminotomy with Bilateral Decompression (TE-ULBD) Using the Outside-In Technique for Thoracic Ossified Ligamentum Flavum
Authors: Kim Hyeun Sung , Wu Pang Hung , Jang Il-Tae
Published: April 2023

Objective: Uniportal full endoscopic thoracic endoscopic surgery can be performed through transforaminal and interlaminar approaches. The interlaminar approach is commonly described as thoracic endoscopic unilateral laminotomy for bilateral decompression (TE-ULBD), which is typically indicated for pathologies such as ossified ligamentum flavum and other posteriorly based compressive pathologies. TE-ULBD decompresses the central and lateral recesses of the thoracic spinal canal. Both the outside-in (over the top of ligamentum flavum) and inside-out (under the ligamentum flavum) approaches can decompress the thoracic spinal canal through the uniportal interlaminar endoscopic route.Methods: A retrospective clinical cohort evaluation of patients who underwent TE-ULBD was performed from January 2018 to December 2021 Results: A cohort of 50 cases of TE-ULBD with a mean age of 65 years old were evaluated. The complication rate was 5.4% and the reoperation rate was 2%. Statistically significant mean VAS improvements were found at 1 week, 6 months, and the final follow-up, with changes of 3.95 ± 1.49, 4.95 ± 1.7, and 5.2 ± 1.8 points, respectively. Likewise, the mean Oswestry Disability Index improvements at 1 week, 3 months, and the final follow-up were 33.8 ± 9.05, 40.12 ± 10.38, and 41.92 ± 11.26, respectively (p < 0.001). Significant improvements were found in the cross-sectional area of the spinal canal in the upper endplate, mid-disc, and lower endplate (57.62 ± 50.6, 89.86 ± 55.93, and 64.93 ± 60.91 mm2, respectively; p < 0.001). Conclusion: TE-ULBD using the outside-in technique could achieve good clinical outcomes and a low rate of complications in our cohort of patients.
Contralateral Inside-out Biportal Endoscopic Posterior Cervical Foraminotomy: Surgical Techniques and Preliminary Clinical Outcomes
Authors: Huang Yu-Hao , Lin Cing-Syue , Pao Jwo-Luen
Published: April 2023

Objective: The aim of this study was to describe the surgical techniques and preliminary results of inside-out biportal endoscopic posterior cervical foraminotomy (BEPCF) for unilateral cervical radiculopathy.Methods: This study involved 36 consecutive patients (38 segments) who underwent BEPCF for unilateral cervical radiculopathy between November 2020 and June 2022. Foraminotomy was performed using the biportal endoscopic technique, with the surgeon standing on the opposite side and making skin incisions on the same side of the foramen stenosis. After widening of the V-point and exposing the nerve root using a high-speed drill, we used a curved osteotome to undercut the facet joint from inside the foramen to complete the nerve root decompression. Results: The study followed patients for an average of 15.5 months and found significant improvements in the visual analog scale for arm pain, from 7.3 ± 2.2 to 0.9 ± 0.7 (P < 0.005), and the Neck Disability Index, from 54.6 ± 16.9 to 14.6 ± 12.6 (P < 0.005). Almost all patients (94.4%) had good or excellent results. Hospitalization lasted an average of 3.2 days and postoperative magnetic resonance imaging showed successful neural decompression. Complications were minimal, with only two cases of asymptomatic root abrasions and one case of transient neuralgia. One patient required re-operation due to incomplete decompression.Conclusion: BEPCF is a safe and effective surgical technique for treating cervical radiculopathy. The surgeon can achieve good neural decompression and preserve the facet joint using the inside-out approach in an ergonomic setting.
Unilateral Biportal Endoscopic Decompression for Thoracic Spinal Stenosis
Authors: Park Man-Kyu , Park Daewon , Son Sang-Kyu
Published: April 2023

In conventional thoracic laminectomy, postoperative complications such as dural tears, cerebrospinal fluid leakage, postoperative infection, and iatrogenic spinal cord injury are relatively common. To address these issues, unilateral biportal endoscopy (UBE) techniques for thoracic laminectomy have been developed and published, demonstrating various advantages over conventional thoracic laminectomy with satisfactory clinical results. In comparison to conventional thoracic laminectomy, the UBE decompression technique with the unilateral approach and bilateral decompression (ULBD) appears to be safe and effective for treating thoracic ossified ligamentum flavum (OLF) or thoracic spinal stenosis. Thoracic ULBD by UBE preserves the paraspinal muscle and ligament that would otherwise be resected during the conventional posterior approach, and it has the added benefit of reducing back pain and muscle atrophy. This manuscript covers the technical aspects of UBE implementation using thoracic ULBD in patients with thoracic OLF or thoracic spinal stenosis, the indications and benefits of this procedure, and tips for preventing complications. With a review of previously published articles on thoracic laminectomy by UBE, we also summarize whether the procedure is safe and can prevent cord injuries.
Identification of a 16-MTGs Prognostic Signature in Diffuse large B-cell lymphoma
Authors: Wang Xiaoqin , Li Guixia , Feng Pengcheng
Published: April 2023

Background: Diffuse large B-cell lymphoma (DLBCL) is one of the largest lymphoma subcategories. Usually, 50-70% of DLBCL patients can be cured by the standard treatment. But at least one third have bad prognosis. Based on this situation, the research on DLBCL therapy strategies is still indispensable.
Method: A prognostic signature was built according to public data and bioinformatics methods, the stability and reliability was assessed and validated. GSEA was performed to explore the difference between different groups. Consensus clustering and immune infiltration analysis were conducted comprehensively.
Results: In this work, a signature based on multiple metabolism-associated genes (MTGs) was established, containing 16 MTGs, to predict the prognosis of DLBCL patients. The accuracy and effectiveness of this signature have been verified by three external validation sets. According to the risk formula, DLBCL patients were divided into high- and low-risk groups, and the survival rate of the low-risk group was significantly higher than that of the high-risk group. Furthermore, Gene set enrichment analysis (GSEA) demonstrated that Beta-alanine metabolism and regulation of actin cytoskeleton signal pathways were enriched in the low-risk group. The actual survival and nomogram-predicted survival matched well both in the training cohort and verification cohorts.
Conclusion: In general, our prognostic signature can provide reliable and valuable information for medical workers in predicting prognosis of DLBCL.
Contextual-Aware and Expert Data Resources for Brazilian Portuguese Hate Speech Detection
Authors: Vargas Francielle , Carvalho Isabelle , Pardo Thiago A. S. , Benevenuto Fabrício
Published: April 2023

This paper provides data resources for low-resource hate speech detection. Specifically, we introduce a large-scale expert annotated corpus of Brazilian Instagram comments and a context-aware offensive lexicon, which was manually extracted by a linguist from the proposed corpus and annotated with contextual information. We further provide native-speaker translations and adaptations from the specialized lexicon for other low-resource languages. The corpus consists of 7,000 document-level multi-layer annotations: (i) a binary offensive class, (ii) offensiveness-level classes, and (iii) nine hate speech targets. The context-aware offensive lexicon holds 1,000 explicit and implicit terms and expressions with pejorative connotations annotated with context-dependent offensiveness and context-independent offensiveness labels. Both corpus and lexicon were annotated by three different experts and achieved high inter-annotator agreement. Finally, we implemented baseline experiments on both data resources (corpus and lexicon). Results show the reliability of the proposed data, outperforming baseline dataset results in Portuguese, as well as presenting promising results for hate speech detection in different languages.
Use of Airfoils for Enhancement of Photosynthesis Rate of Microalgae in Raceway
Authors: Inostroza Cristian , Dávila Javier , Román Sergio , Fernández-Sevilla José M. , Acién F. Gabriel
Published: April 2023

The lack of adequate vertical mixing is one of the factors limiting the productivity of open raceway microalgae reactors. The existence of large gradients of light involves the cells being mainly adapted to local irradiance instead of average irradiance, which would allow for maximizing the light utilization efficiency, thus maximizing the biomass productivity of microalgae cultures. To overpass this problem different alternatives have been proposed, one of the more suitable being the utilization of airfoils to improve vertical mixing. In this work, numerical and experimental studies were performed to analyse the effect of the aerodynamic airfoils patented by the University of Seville (WO2020120818A1). The goal is to improve the photosynthetic efficiency, but also a better understanding of the light regime to which the microalgae cells are exposed in these systems and how to improve it. Computational Fluid Dynamics (CFD) was used to optimize the flow generated by the airfoils. A dynamic photosynthesis model (Rubio Camacho et al., 2003) was used to estimate the photosynthesis rate as a function of the light regime to which the cells are exposed, including photo-adaptation and photo-inhibition phenomena. The results confirm that the use of airfoils improves the vertical mixing and the photosynthesis rate, with a negligible increase in energy consumption. The photosynthetic benefits were observed 10 m downstream of the airfoils, resulting in an increase in photosynthesis rate and productivity by up to 30%. These results confirm the benefits of an increase in mixing in microalgae cultures, especially when focusing on the movement of the cells between the different illuminated zones while maintaining low energy consumption and CAPEX.
Pruritus Related to Trastuzumab and Pertuzumab in HER2+ Breast Cancer Patients
Authors: Gu Stephanie , Dusza Stephen , Quigley Elizabeth , Haliasos Helen , Markova Alina , Marchetti Michael , Moy Andrea , Dang Chau , Modi Shanu , Lake Diana , Noor Sarah , Lacouture Mario
Published: April 2023

Purpose
The combination of trastuzumab and pertuzumab (HP) as part of a taxane-based regimen has shown benefit in the adjuvant and metastatic HER2+ breast cancer setting. In the CLEOPATRA trial, pruritus was reported in 11-17.6% of patients. The clinical phenotype and potential treatment strategies for this event have not been reported.
Methods
A retrospective review of 2583 patients receiving trastuzumab and pertuzumab for the treatment of HER2+ breast cancer from 11/23/2011 to 6/21/2021 was performed at Memorial Sloan Kettering Cancer Center (MSKCC). Patient demographics, pruritus characteristics, and treatments as documented in the electronic medical record (EMR) were included in this analysis.
Results
Of 2583 pts treated with HP, 122 (4.72%) with pruritus were identified. On average, patients experienced pruritus 319.0 days (8-3171) after initiation of HP. The upper extremities (67.4%), back (29.3%), lower extremities (17.4%), and shoulders (14.1%) were the most commonly affected regions. Grade 1/2 pruritus (97.6%) occurred in most cases. Patients responded primarily to treatment with topical steroids (52.2%), antihistamines (29.9%), emollients (20.9%), and gabapentinoids (16.4%). Of those with pruritus, 4 patients (3.3%) required treatment interruption or discontinuation.
Conclusions
Pruritus is uncommon in patients on trastuzumab and pertuzumab, generally a chronic condition, with gabapentinoids or antihistamines representing effective therapies.
SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
Authors: Love J. , Rodriguez-Aponte Sergio , Tostanoski Lisa , Dalvie Neil , Johnston Ryan , Jacob-Dolan Catherine , Powers Olivia , Hachmann Nicole , Miller Jessica , Hall Kevin , Siamatu Mazuba , Mazurek Camille , Surve Nehalee , Barouch Dan
Published: April 2023

We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs).
RETRACTED: Porosity gradient control of 3D printed hybrid foam structures
Authors: Pawar Ajinkya , Ausias Gilles , Corre Yves-Marie , Grohens Yves , Férec Julien
Published: April 2023

The authors have requested that this preprint be removed from Research Square.
A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers
Authors: Huang Hao , Qiu Duoliang , Zhou Zhengyang , Wu Biaobiao , Shao Lening , Pu Yuwei , He Tengfei , Wu Yongyou , Cui Dawei , Zhong Fengyun
Published: April 2023

Background Human health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated with cancer risk, Nevertheless, no pan-cancer analysis has been conducted on CDKN1B in human cancers.Methods With the help of bioinformatics, a pan-cancer analysis was conducted on the expression levels of CDKN1B in cancer tissues and adjacent tissues from the TCGA, CPTAC and GEO databases. The CDKN1B expression levels in tumor patients was further validated using immunohistochemistry (IHC) and quantitative real-time PCR.Results In the study, we first investigated the cancer-related roles of CDKN1B's in 40 tumors with malignancy. The CDKN1B gene encodes the p27Kip1 protein, which can block the production cyclin-dependent kinase (CDK), which is obviously related to the function and survival of cancer cells and alters the prognosis of cancer patients. Furthermore, CDKN1B function requires both protein processing and RNA metabolism. Additionally, the elevated expression of the CDKN1B gene and protein was validated in several cancer tissues from the patients.Conclusions These results showed that the levels of CDKN1B were considerably different in a number of cancer tissues, offering a potential future target for cancer therapy.
Visual design of art based on interactive technology and environment aware intelligent devices
Authors: Li Jingyao
Published: April 2023

In the digital era, visual programming technology has brought fresh blood to the field of art creation, making it completely realize the structural transformation, thus promoting art design to get rid of the limitations of traditional media. Based on the integration of environment awareness technology and interactive technology, this paper realizes the design and improvement of art interactive creation visualization system. The environmental awareness technologies included in the system are divided into several types with different application effects, including data storage and collection technology, data processing technology and scenario management technology. The system itself is designed as a three-tier system, including application layer, foundation layer and user interaction layer. By using environment awareness technology, the system realizes the collection and source analysis of target data, and can perform scenario state calculation, information reasoning and storage. By introducing visualization technology, the system is equipped with a visual programming model, which can realize programming processing based on node data. It can be seen from the simulation experiment data that the system can achieve efficient and feasible data processing, and its memory utilization, CPU utilization and requests, bandwidth and other indicators are positively correlated. Therefore, the application of this visualization system can effectively assist individual artists in artistic creation, break communication barriers, achieve information interaction, bring new possibilities for artistic creation, and effectively adapt to the future art development environment. In this paper, the visual system is designed by applying environment awareness and interactive technology to the field of art design.
Ludwig’s Angina with facial nerve palsy, a rare presentation
Authors: Bogale Manendante , Alemayehu Dawit , Deresse Tilahun , Assefa Wubshet , Dessalegn Megbar
Published: April 2023

Ludwig's angina is an inflammation of neck spaces making it immediately life-threatening. The infection spreads to adjacent planes destructing facial planes, aspirations of infective particles, or septic embolism to distant areas. This is about a 40 years-old man who presented with painful anterior neck swelling of 7 days duration. A diagnosis of Ludwig’s angina with unilateral facial nerve paralysis and treated with immediate incision and drainage. Although facial nerve palsy associated with Ludwig’s angina is rare, it improves with immediate surgical decompression.
Accuracy and efficiency of two control strategies in commanding a robotic laparoscope holder by foot: An experimental study on surgeons' use pattern
Authors: Yang Yan-Jun , Vadivelu Arvind , Hepworth Jessica , Zeng Yongpeng , Pilgrim Charles , Kulic Dana , Abdi Elahe
Published: April 2023

The implementation of a laparoscope-holding robot in minimally invasive surgery enhances the efficiency and safety of the operation. However, the extra robot control task can increase the cognitive load on surgeons. A suitable interface may simplify the control task and reduce the surgeon load. Foot interfaces are commonly used for commanding laparoscope-holding robots, with two control strategies available: decoupled control permits only one Cartesian axis actuation, known as decoupled commands; hybrid control allows for both decoupled commands and multiple axes actuation, known as coupled commands. This paper aims to determine the optimal control strategy for foot interfaces by investigating two common assumptions in the literature: 1. Decoupled control is believed to result in better predictability of the final laparoscopic view orientation, and 2. Hybrid control has the efficiency advantage in laparoscope control. Our user study with 11 experienced and trainee surgeons shows that decoupled control has better predictability than hybrid control, while both approaches are equally efficient. In addition, using two surgery-like tasks in a simulator, users' choice of decoupled and coupled commands is analysed based on their level of surgical experience and the nature of the movement. Results show that trainee surgeons tend to issue more commands than the more experienced participants. Single decoupled commands were frequently used in small view adjustments, while a mixture of coupled and decoupled commands was preferred in larger view adjustments. A guideline for foot interface control strategy selection is provided.
Association between Dietary Vitamin E Intake and Cognitive Decline Among old American: National Health and Nutrition Examination Survey
Authors: Zhang kai , Han Yu , Gu Zhaoxuan , Hou Zhengyan , Yu Xiaoqi , Gao Min , Cai Tianyi , Gao Yafang , Xie Jinyu , Gu Fangming , Chen Jianguo , Chen Bowen , Liu Tianzhou
Published: April 2023

Purpose: Numerous studies have reported that vitamin E plays a key role in nervous system development and neurotransmitter production.This study aimed to investigate changes in vitamin E intake in older adults with low cognitive performance using NHANES.
Methods: In this cross-sectional study, we examined a sample of 2,255 American adults aged 60 and over between 2011 and 2014. We collected dietary data by averaging two recalls for dietary use to determine vitamin E intake. We assessed cognitive function using five tests and analyzed the association between these variables using a multivariate logistic regression model.
Results: A total of 2255 participants aged ≥60 years from the National Health and Nutrition Examination Survey (NHANES) for the 2011-2014 cycle were included in the analysis. Vitamin E intake was negatively associated with cognitive function. In the Z-test, each 1 mg/day increase in dietary intake of vitamin E was associated with a 6% lower likelihood of severe cognitive performance in the fully fitted model (OR = 0.94, 95% CI: 0.91~0.97) The results did not change when exposure was analyzed as a categorical variable. Compared with Q1, Q4 reduced the risk of cognitive impairment by 53% in the z-test (OR = 0.47, 95% CI: 0.33~0.67).No significant statistical interaction between the variables was found
Conclusions: An increased dietary intake of vitamin E has been associated with decreased cognitive impairment in individuals over 60 years old. The dose-response curve showed an L-shaped association between dietary vitamin E intake and cognitive decline in US adults, with an inflection point of approximately 9.296 mg/day.
On-chip phonon-magnon reservoir for neuromorphic computing
Authors: Scherbakov Alexey , Yaremkevich Dmytro , De Clerk Luke , Kukhtaruk Serhii , Campion Richard , Rushforth Andrew , Savel’ev Sergey , Balanov Alexander , Bayer Manfred , Nadzeyka Achim
Published: April 2023

Reservoir computing is a concept in which signals to process are mapped onto a high-dimensional phase space of a fixed dynamical system called “reservoir” for subsequent recognition by an artificial neural network. Implementations of reservoirs are possible using different hardware and, accordingly, exploit different carriers and mechanisms of signal transformation. Despite the growing number of neuromorphic prototypes of reservoirs, demands for miniaturization, efficiency, and robustness all require implementation of the reservoir on a chip, and remain among the key challenges. Here we propose a nanodevice, in which a sandwich of a semiconductor phonon waveguide and a patterned ferromagnetic layer enables efficient reservoir computing. The optical input signal is coded by a pulsed write-laser and converted into a propagating multimode phonon wave packet, which interacts with a bunch of magnon modes. The output signal read by a second laser represents a phase-sensitive superposition of all the phonon and magnon modes, which possesses ultimate sensitivity to the relative positions of the write- and read-laser spots. The reservoir efficiently separates the visual shapes drawn by the write-laser beam on the nanodevice surface in an area with size comparable to a single pixel of a modern digital camera. Thus, our finding suggests the phonon-magnon interaction as a promising hardware basis for realization of rapid on-chip reservoir computing for future neuromorphic architectures.
Transmission of Alzheimer's Disease-Associated Microbiota Dysbiosis and its Impact on Cognitive Function: Evidence from Mouse Models and Human Patients
Authors: Zhang Yiying , Shen Yuan , Liufu Ning , Liu Ling , li wei , Shi Zhongyong , Zheng Hailin , Mei Xinchun , Chen Chih-Yu , Jiang Zengliang , Abtahi Shabnamsadat , Dong Yuanlin , Liang Feng , Shi Yujiang , Cheng Leo , Yang Guang , Kang Jing X. , Wilkinson Jeremy , Xie Zhongcong
Published: April 2023

Spouses of Alzheimer’s disease (AD) patients are at higher risk of developing AD dementia, but the reasons and underlying mechanism are unknown. One potential factor is gut microbiota dysbiosis, which has been associated with AD. However, it remains unclear whether the gut microbiota dysbiosis can be transmitted to non-AD individuals and contribute to the development of AD pathogenesis and cognitive impairment. The present study found that co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, Tau phosphorylation, and cognitive impairment. Gavage with Lactobacillus and Bifidobacterium restored these changes. The oral and gut microbiota of AD patient partners resembled that of AD patients but differed from healthy controls, indicating the transmission of oral and gut microbiota and its impact on cognitive function. The underlying mechanism of these findings includes that the butyric acid-mediated acetylation of GSK3β at lysine 15 regulated its phosphorylation at serine 9, consequently impacting Tau phosphorylation. These results provide insight into a potential link between gut microbiota dysbiosis and AD and underscore the need for further research in this area.
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib
Authors: Wang Dandan , Wei Yimei , Xu Lulu , Zhang Jie
Published: April 2023

Background and objective: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by fibrosis and vascular lesions. Interstitial lung disease (ILD) is an early complication of SSc and the main cause of death from SSc. Although baricitinib shows good efficacy in a variety of connective tissue diseases, its role in systemic sclerosis-related interstitial lung disease (SSc-ILD) is unclear. The objectiveof our study was to explore the effect and mechanism of baricitinib in SSc-ILD.
Methods: We explored crosstalk between the JAK2 and TGF-β1 pathways. In vivo experiments, SSc-ILD mice model were constructed by subcutaneous injection of PBS or bleomycin (7.5 mg/kg) and intragastric administration of 0.5% CMC-Na or baricitinib (5 mg/kg) once every two days. We used ELISA, qRT‒PCR, western blotand immunofluorescence staining to evaluate the degree of fibrosis. In vitro experiments, we used TGF-β1 and baricitinib to stimulate human fetal lung fibroblasts (HFLs) and assessed protein expression by western blot.
Results: The vivo experiments showed that baricitinib notably alleviated skin and lung fibrosis, decreased the concentration of pro-inflammatory factors and increased those of the anti-inflammatory factors. Baricitinib affected the expression of TGF-β1 and TβRI/II inhibitiing JAK2. In the vitro experiments, following the culture of HFLs with baricitinib or a STAT3 inhibitor for 48 h, the expression levels of TβRI/II decreased. Conversely, with successful inhibition of TGF-β receptors in HFLs, JAK2 protein expression decreased.
Conclusions: Baricitinib attenuated bleomycin-induced skin and lung fibrosis in SSc-ILD micemodel by targeting JAK2 and regulating of the crosstalk between the JAK2 and TGF-β1 signaling pathways.
Evolution of Wolbachia reproductive and nutritional mutualism: insight from two novel strains that double infect pollinator of dioecious Ficus hirta
Authors: Liu Wanzhen , Xia Xue , Ding Yamei , Fang Ji-Chao , Yu Hui
Published: April 2023

Wolbachia is a genus of endosymbiont which can manipulate the reproductive system of hosts and exert an influence on metabolic processes. Wolbachia is dominant in male syconium of dioecious Ficus hirta with pollinator Valisia javana. From high-quality chromosome-level V. javana genome with PacBio long-read and Illumina short read sequencing, we discovered a sizeable proportion of Wolbachiasequences and then assembled two novel strains belonging to supergroup A. Besides the basic genome description, we identified mobile genetic elements including prophages and insertion sequences, genes related to biotin synthesis and metabolism, and cytoplasmic incompatibility related cif genes in them. The results showed that (i) A total of two prophages and 201 insertion sequences were found. The prophage WOjav1 is cryptic and WOjav2 relatively intact. IS5 is dominant family. (ii) At least three pairs of cif genes belong to type I and is speculated to cause strong CI with infected female biased reproductive advantages; (iii) The Wolbachiaonly provide biotin precursors to absorb and metabolize biotin which is synthesized by host plant. This research provided a basis for reproductive and nutritional mutualism between Wolbachiaand fig-fig wasp system, and will serve as a useful resource for further research into Wolbachia-pollinator-host interactions.