bluuebunny/crossref_metadata_2025 huggingface dataset:
Allocating Scarce Organs: How a Change in Supply Affects Transplant Waiting Lists and Transplant Recipients
Authors: Dickert-Conlin Stacy , Elder Todd , Teltser Keith
Published: September 2019

Vast organ shortages motivated recent efforts to increase the supply of transplantable organs, but we know little about the demand side of the market. We test the implications of a model of organ demand using the universe of US transplant data from 1987 to 2013. Exploiting variation in supply induced by state-level motorcycle helmet laws, we demonstrate that each organ that becomes available from a deceased donor in a particular region induces five transplant candidates to join that region's transplant wait list, while crowding out living-donor transplants. Even with the corresponding demand increase, positive supply shocks increase post-transplant survival rates. (JEL D47, I11, I18)
Children and Gender Inequality: Evidence from Denmark
Authors: Kleven Henrik , Landais Camille , Søgaard Jakob Egholt
Published: September 2019

Using Danish administrative data, we study the impacts of children on gender inequality in the labor market. The arrival of children creates a long-run gender gap in earnings of around 20 percent driven by hours worked, participation, and wage rates. We identify mechanisms driving these “child penalties” in terms of occupation, sector, and firm choices. We find that the fraction of gender inequality caused by child penalties has featured a dramatic increase over the last three to four decades. Finally, we show that child penalties are transmitted through generations, from parents to daughters, suggesting an influence of childhood environment on gender identity. (JEL D63, J13, J16, J22, J31, J71)
Regulating Markups in US Health Insurance
Authors: Cicala Steve , Lieber Ethan M. J. , Marone Victoria
Published: September 2019

A health insurer's Medical Loss Ratio (MLR) is the share of premiums spent on medical claims, or the inverse markup over average claims cost. The Affordable Care Act introduced minimum MLR provisions for all health insurance sold in fully insured commercial markets, thereby capping insurer profit margins, but not levels. While intended to reduce premiums, we show this rule creates incentives to increase costs. Using variation created by the rule's introduction as a natural experiment, we find medical claims rose nearly one-for-one with distance below the regulatory threshold: 7 percent in the individual market and 2 percent in the group market. Premiums were unaffected. (JEL G22, H51, I13, I18)
Can mammogram readers swiftly and effectively learn to interpret first post-contrast acquisition subtracted (FAST) MRI, a type of abbreviated breast MRI?: a single centre data-interpretation study
Authors: Jones Lyn I , Geach Rebecca , Harding Sam A , Foy Christopher , Taylor Victoria , Marshall Andrea , Taylor-Phillips Sian , Dunn Janet A
Published: September 2019

Objectives:

To assess whether NHS breast screening programme (NHSBSP) mammogram readers could effectively interpret first post-contrast acquisition subtracted (FAST) MRI, for intended use in screening for breast cancer.

Methods:

Eight NHSBSP mammogram readers from a single centre (four who also read breast MRI (Group 1) and four who do not (Group 2)) were given structured FAST MRI reader training (median 4 h: 32 min). They then prospectively interpreted 125 FAST MRIs (250 breasts: 194 normal and 56 cancer) comprising a consecutive series of screening MRIs enriched with additional cancer cases from 2015, providing 2000 interpretations. Readers were blinded to other readers’ opinions and to clinical information. Categorisation followed the NHSBSP MRI reporting categorisation, with categories 4 and 5 considered indicative of cancer. Diagnostic accuracy (reference standard: histology or 2 years’ follow-up) and agreement between readers were determined.

Results:

The accuracy achieved by Group 2 (847/1000 (85%; 95% confidence interval (CI) 82–87%)) was 5% less than that of Group 1 (898/1000 (90%; 95% CI 88–92)). Good inter-reader agreement was seen between both Group 1 readers (κ = 0.66; 95% CI 0.61–0.71) and Group 2 readers (κ = 0.63; 95% CI 0.58–0.68). The median time taken to interpret each FAST MRI was Group 1: 34 s (range 3–351) and Group 2: 77 s (range 11–321).

Conclusion:

Brief structured training enabled multiprofessional mammogram readers to achieve similar accuracy at FAST MRI interpretation to consultant radiologists experienced at breast MRI interpretation.

Advances in knowledge:

FAST MRI could be feasible from a training-the-workforce perspective for screening within NHSBSP.
Activation of the leptin pathway by high expression of the long form of the leptin receptor (Ob-Rb) accelerates chondrocyte senescence in osteoarthritis
Authors: Zhao Xiang , Huang Ping , Li Gen , Lv Zhendong , Hu Guangyu , Xu Qingrong
Published: September 2019

Objectives

Activation of the leptin pathway is closely correlated with human knee cartilage degeneration. However, the role of the long form of the leptin receptor (Ob-Rb) in cartilage degeneration needs further study. The aim of this study was to determine the effect of increasing the expression of Ob-Rb on chondrocytes using a lentiviral vector containing Ob-Rb.

Methods

The medial and lateral cartilage samples of the tibial plateau from 12 osteoarthritis (OA) patients were collected. Ob-Rb messenger RNA (mRNA) was detected in these samples. The Ob-Rb-overexpressing chondrocytes and controls were treated with different doses of leptin for two days. The activation of the p53/p21 pathway and the number of senescence-associated β-galactosidase (SA-β-gal)-positive cells were evaluated. The mammalian target of rapamycin (mTOR) signalling pathway and autophagy were detected after the chondrocytes were treated with a high dose of leptin.

Results

In total, 12 cases were found to have severe medial cartilage wear compared with the lateral cartilage. Immunofluorescence showed that the expression of Ob-Rb in the medial cartilage of the tibial plateau was high. High levels of leptin led to cell cycle arrest and inhibited autophagy. After overexpression of Ob-Rb, the physiological dose of leptin induced cell senescence in the chondrocytes. High doses of leptin inhibited autophagy by activating the mTOR signalling pathway. Blockade of the mTOR signalling pathway could restore autophagy and partially reverse senescence induced by leptin in chondrocytes.

Conclusion

In summary, the present study demonstrated that high doses of leptin induce cell senescence by activating the mTOR pathway in chondrocytes from OA cartilage. Highly expressed Ob-Rb accelerates chondrocyte senescence by activating the leptin pathway in OA. Cite this article: X. Zhao, P. Huang, G. Li, L. Zhendong, G. Hu, Q. Xu. Activation of the leptin pathway by high expression of the long form of the leptin receptor (Ob-Rb) accelerates chondrocyte senescence in osteoarthritis. Bone Joint Res 2019;8:425–436. DOI: 10.1302/2046-3758.89.BJR-2018-0325.R2.
A reply to John Barry
Authors: Baker Stephen
Published: September 2019

In his analysis of the loyalist flag protests of 2012, John Barry finds within them the potential for a civic, progressive politics beyond ethnic grievance; a post-conflict politics that need not be post-political; an agonistic politics of struggle and contestation that need not be violent. As a means to achieve this, John defends the need for single-identity/internal conversations within loyalism. In my reply, I am broadly supportive, but I suggest that such conversations cannot take for granted the continuation of the constitutional status quo.
Overlooking British experiences: a reply to Evershed
Authors: Johnson Matthew
Published: September 2019

Jonathan Evershed presents a compelling account of the clear dangers that lie in forms of state-led remembrance. The danger is, of course, that, in commemorating, actual experience is lost. While I do not wish to challenge any of the core claims in the piece, I do think that there is one element that requires greater examination: Evershed’s claim that contemporary Irish conceptions of the First World War as ‘A war that stopped a war’ ‘contributes to a (post)colonial and militaristic nostalgia in British political culture’. While the dangers of that for Northern Ireland are clear, perhaps the greatest risks lie in England, since any such benign account of the conflict serves radically to distort the experience of those soldiers commonly regarded as identifying as British and painted as being motivated by patriotism. Drawing on experience from Tyneside, I argue that, in considering the nature of that conflict, we must remember the many diverse, and often banal, reasons for working class engagement in conflict.
Scientific knowledge in the age of computation: Explicated, computable and manageable?
Authors: Efstathiou Sophia , Nydal Rune , Laegreid Astrid , Kuiper Martin
Published: September 2019

We have two theses about scientific knowledge in the age of computation. Our general claim is that scientific Knowledge Management practices emerge as second-order practices whose aim is to systematically collect, take care of and mobilise first-hand disciplinary knowledge and data. Our specific thesis is that knowledge management practices are transforming biological research in at least three ways. We argue that scientific Knowledge Management a. operates with founded concepts of biological knowledge as explicated and computable, b. enables new outputs and ways of knowing within biology, and c. risks enforcing objectivist epistemologies of knowledge as some one objective thing.
Procesos de (re)territorialización en localidades campesinas de Chiapas (México) en contextos migratorios
Authors: Castillo Ramírez Guillermo , Pérez Campuzano Enrique
Published: September 2019

En el contexto de la migración México-Estados Unidos, este artículo aborda, desde una perspectiva territorial, los cambios en el territorio en dos localidades campesinas de Las Margaritas (en Chiapas, México), ocasionados por la migración internacional a inicios de siglo. Este trabajo argumenta que, si bien hubo cambios relacionados con la migración –como ausencia de jóvenes, envío de remesas, reacomodos familiares y comunitarios-, se mantuvieron antiguos procesos de territorialización –producción agrícola, prácticas socioculturales comunitarias y formas de organización local–.
Mapeo de las Publicaciones Científicas entre América Latina, el Caribe y la Unión Europea
Authors: Belli Simone , Balta Joan
Published: September 2019

El mapeo de la colaboración científica birregional requiere múltiples enfoques para obtener una imagen lo más completa posible. El primer indicador de esta colaboración es el número y la tipología de co-publicaciones científicas entre autores de ambas regiones. Este artículo analiza las publicaciones científicas que figuran en la base de datos de Web of Science, que incluye a coautores de países de eulac entre 2005 y 2016, prestando especial atención a las áreas de investigación más destacadas y al papel de las agencias nacionales de investigación en la promoción de la cooperación internacional. Además, se introduce un indicador específico, la fuerza del enlace, para dar cuentas de las alianzas destacadas entre países, así como de la conexión de un determinado país dentro de la red trazada por el cojunto de co-publicaciones analizadas. Nuestro estudio destaca la capacidad de los países de eulac en la generación de redes científicas y su papel relevante en una creciente red mundial de investigadores de diversos países que hace cada vez más difícil aislar una colaboración científica interregional específica.
Морфологический и таксономический анализ полиморфного комплекса Spiraea betulifolia – Spiraea beauverdiana в России
Authors: Kostikova V.A. , Kuznetsov A.A. , Troshkina V.I. , Belanova A.P.
Published: September 2019

Изучено разнообразие растений рода Spiraea L. секции Calospira C. Coch по количественным морфологическим признакам из 32 природных выборок. Сделан ключ для определения видов. На территории Азиатской России произрастает два вида спирей секции Calospira ‒ S. betulifolia Pall. и S. beauverdiana C.K. Schneid., которые, вероятно, ранее представляли 2 экотипа одного вида. На островной части Азиатской России (о. Сахалин, Курильские острова) произрастает подвид S. betulifolia Pall. subsp. aemiliana (C.K. Schneid.) H. Hara. Отличительными признаками его являются мелкая округлая или лопатчатая (обратнояйцевидная) листовая пластинка и отсутствие опушения веточек соцветия, а также ряд метрических признаков, средние значения которых не перекрываются со средними значениями S. betulifolia и S. beauverdiana. Этот таксон имеет тенденцию к стабилизации по морфологическим признакам, но достаточно ещё не отделился от S. betulifolia.
Флороценотическое разнообразие лесостепного комплекса урочища «Бойцы» (Ставропольская возвышенность,	Прикалаусские высоты)
Authors: Likhvar A.V.
Published: September 2019

В настоящей работе приведен обзор флористического разнообразия лесостепного комплекса урочища «Бойцы» Прикалаусско-Буйволинского ландшафта. Дано описание рельефа территории и его форм, отмечены коренные породы, типы почв и др. Несмотря на свое фиторазнообразие, в ботаническом отношении территория является не изученной. Впервые приводятся описание растительного покрова равнинных участков, склонов, балок, потяжин с соответствующими флористическим рядами. Указаны основные доминанты древесного и кустарникового яруса, а также виды с широкой экологической валентностью. На территории района исследования выявлены ксерофильные и петрофильные группировки, составляющие основу раритетной флоры урочища.
Clement of Alexandria
Authors: Kovacs Judith L.
Published: September 2019

Dieser Beitrag untersucht das originäre Denken Klemens von Alexandriens (ca. 150 - ca. 215), eines frühen Interpreten der gesamten Bibel und Wegbereiter der philosophischen Interpretation des Evangeliums. Er behandelt zunächst Klemens Leben, Werk und Kontext in Alexandria und betrachtet anschließend seine Antworten auf die folgenden Fragen: (1) Was ist der Sinn des menschlichen Lebens? (2) Wer ist Gott und wie kann er erkannt werden? (3) Was ist Gottes Gesamtplan für die Erlösung des Menschen? (4) Wie soll der Christ zur Vollkommenheit und ewigen Betrachtung Gottes vorankommen? Klemens war ein optimistischer und aufgeschlossener Wahrheitssuchender in einer Zeit, in der die christliche Religion gerade erst Gestalt annahm. Er war der Ansicht, dass die Erkenntnis Gottes und die Liebe zu ihm der Grund des Seins des menschlichen Lebens sei und dass Gottes Heilsplan ein komplexes System der Erziehung und Vollkommenheit beinhalte. Dieser schließe auch Christus, das göttlichen Wort, den ultimativen Lehrer, ein. Seine biblische Exegese und Theologie hinterließen ein wichtiges Vermächtnis bei späteren Theologen, insbesondere im griechischsprachigen Osten.
Basilius von Cäsarea (329?–378?) in der Polyphonie der Kirchenväter
Authors: Zachhuber Johannes
Published: September 2019

The article offers a brief presentation of Basil of Caesarea (329-378) in the context of a polyphony of the church fathers. Basil, one of the most influential figures in the entire history of the Eastern Church, held close contacts with many other major theologians and bishops of his time. His large corpus of extant letters gives a strong sense of his participation in a polyphonic interaction between diverse Christian voices. Yet he is also elusive and often difficult to integrate into conventional categories of patristic history. This can be explained by his pragmatic approach to theology which uniquely combines deep intellectual sophistication with a level-headed awareness of the practical needs of the Church in his own time.
Juventude e magreza
Authors: Neiva Renata Maria de Oliveira
Published: September 2019

RESUMO

É proibido ser gorda. Não se envelhece mais. A beleza se constrói. Como um dos maiores jornais brasileiros do século XX contribuiu para a educação do corpo feminino. Pelas páginas do Correio da Manhã, as mulheres encontraram, recorrentemente, duas prescrições: antipeso e antienvelhecimento.

PALAVRAS-CHAVE:Imprensa. Mulheres. Educação.

 

ABSTRACT

Women are not allowed to be fat. There is no more aging. Beauty is built. The way one of the greatest Brazilian newspapers of the twentieth century contributed to the education of the female body. In the pages of the newspaper Correio da Manhãwomen have, repeatedly, found two prescriptions: anti-weight gain and anti-aging.

KEYWORDS: Press. Women. Education.
Experiências femininas na carreira da docência superior: entre o cotidiano da “casa” e da profissão
Authors: Furlin Neiva
Published: September 2019

Este artigo analisa narrativas de mulheres (casadas e freiras) que atuam na docência superior em teologia católica, e pretende evidenciar como elas circulam entre a profissão e os trabalhos domésticos, naturalizados como femininos.

PALAVRAS-CHAVE: Divisão sexual do trabalho. Docência superior. Desigualdade de gênero. Profissão..

 

ABSTRACT

This article analyzes narratives of women (married and nuns) who teach Catholic theology at a college level and aims to show how they circulate between their profession and housework, culturally considered women’s work.

KEYWORDS: Sexual division of labor. Higher education teaching. Gender inequality. Profession
Deusa e/ou bruxa? Uma análise dos dizeres sobre o feminino ontem e hoje
Authors: Daróz Elaine Pereira , Garcia Dantielli Assumpção , Abrahão e Sousa Lucília Maria
Published: September 2019

Filiados à Análise de Discurso (Pêcheux), propomos uma análise dos dizeres sobre a mulher presentes no romance português A dama pé de cabra, que se atualizam nos jornais jornalístico (online), para compreendermos o lugar dessa memória sobre a mulher na esfera social.

PALAVRAS-CHAVE: Análise de Discurso. Mídia. Mulher. Memória.

 

ABSTRACT

In the light of the theoretical assumptions of Discourse Analysis (Pêcheux), we propose an analysis of the discourses about women, present on the Portuguese novel The lady of the goat, and updated in online journalistic discourse, in order to understanding of the imaginary about women on the social sphere.

KEYWORDS: Discourse Analysis. Media. Woman. Memory.
Learning through Linguistic citizenship: Finding the “I” of the essay
Authors: Bock Zannie , Abrahams Lauren , Jansen Keshia
Published: September 2019

In recent years, the South African higher education system has seen growing calls for broadened epistemic access, decolonised curricula and transformed institutions. Scholars across South Africa have taken up the challenge and are working on new theoretical approaches to teaching and learning in higher education. In this paper, we reflect on students’ experiences of a multilingual, multimodal module called Reimagining Multilingualisms, which was jointly offered by the Universities of the Western Cape and Stellenbosch in April and May of 2018. In this paper, we provide an overview of the module and the different types of activities it involved. We reflect on these experiences using the theoretical lenses of decolonial scholar Mignolo (2009) on the ‘locus of enunciation’, and Stroud (2018) on ‘Linguistic Citizenship’. We present extracts from focus group interviews with students from both campuses to illustrate the involvement of ‘the body’ in ‘knowing’ and the ways in which the module enabled different ‘voices’ to emerge. We focus particularly on the role played by students’ perceived ‘vulnerability’ in the transformative benefits of the module and discuss this by way of conclusion. In sum, we suggest how the centring of multilingualism and diversity – not only as core pedagogic principles, but also as a methodology for transformation – may be used to enhance access and recapture voice in the building of a more integrated and just society.
Poems and reflections on language and the theme of home
Authors: Authors Various
Published: September 2019

This section comprises poems and reflections on language in relation to the theme of home.
KAJIAN KONTRIBUSI UMKM BERBASIS RUMAH ECENG GONDOK MELALUI PENGGUNAAN INTERNET TERHADAP PENDAPATAN PELAKU USAHA DI KAWASAN RAWAPENING
Authors: Sianturi Onixtin Octarina , Tyas Wido Prananing
Published: September 2019

Rawapening merupakan danau semi alami dengan luas 2.670 hektare yang terletak di 4 wilayah kecamatan, yaitu Kecamatan Ambarawa, Tuntang, Bawen dan Banyubiru. Sekitar 80% dari permukaan air di Rawapening ditumbuhi tanaman eceng gondok yang menyebabkan kondisinya semakin parah akibat penurunan daya tampung. Eceng gondok juga menyimpan potensi bagi upaya pengembangan ekonomi masyarakat melalui UMKM berbasis rumah. Meskipun kerajinan eceng gondok berbasis bahan alam dan cenderung tradisional, namun adanya dukungan internet dalam hal kemudahan komunikasi, transaksi jual beli, dan penyebaran informasi sehingga menarik untuk diteliti lebih lanjut. Penelitian ini bertujuan untuk mengetahui seberapa besar kontribusi HBE eceng gondok di sekitar Rawapening berbasis internet terhadap pendapatan pelaku usaha. Penelitian ini dianalisis menggunakan analisis deskriptif kuantitatif dan didukung oleh data kualitatif berdasarkan hasil wawancara. Hasil penelitian menunjukkan rata-rata kontribusi HBE terhadap pendapatan pelaku HBE non digital yaitu 75% dengan pendapatan Rp1.414.585. Berbeda kondisi, rata-rata kontribusi HBE terhadap pendapatan pelaku HBE digital yaitu 81% dengan pendapatan Rp5.162.500.
PENGEMBANGAN HOMESTAY BERBASIS MASYARAKAT PADA KAMPUNG HOMESTAY BOROBUDUR
Authors: Wedatama Abid Affandi , Mardiansjah Fadjar Hari
Published: September 2019

Candi Borobudur merupakan destinasi wisata yang termasuk ke dalam Situs Warisan Dunia UNESCO pada tahun 1991 yang memberikan potensi pengembangan aktivitas ekonomi serta pariwisata. Masyarakat Dusun Ngaran 2 Desa Borobudur memanfaatkan potensi pariwisata dengan melakukan pengembangan homestay berupa Kampung Homestay Borobudur yang hingga saat ini mencapai 27 homestay dengan melibatkan elemen masyarakat dan para pengelola homestay Dusun Ngaran 2. Penelitian ini menggunakan metode kualitatif dan pendekatan eksploratif untuk menjelaskan proses pengembangan homestay serta analisis triangulasi dan penarikan kesimpulan untuk mengetahui peran masyarakat dan teknologi informasi di dalamnya.  Pengembangan homestay yang berbasis pada masyarakat ini melibatkan dua aspek kegiatan yaitu peningkatan mutu pelayanan dan penyedia kegiatan pariwisata. Selain itu, terdapat juga peran teknologi informasi yang digunakan untuk sistem pemesanan yang terkomputerisasi pada media booking.com atau melalui situs yang dibangun khusus oleh pengurus homestay pada www.kampunghomestayborobudur.com sebagai bagian dari pengembangan aktivitas pariwisata, ekonomi dan teknologi untuk menciptakan pariwisata yang berkelanjutan.
PERAN STAKEHOLDER DALAM PENGELOLAAN WISATA PANTAI DI KELURAHAN AIR MANIS, KECAMATAN PADANG SELATAN
Authors: Gustina Rizky Dwi , Mussadun Mussadun
Published: September 2019

Pantai Air Manis merupakan salah satu wisata yang sedang dikembangkan oleh pengelola wisata, Dinas Kebudayaan dan Pariwisata Kota Padang. Kondisi dan ketersediaan atraksi maupun fasilitas wisata yang tersedia masih kurang. Penelitian ini bertujuan untuk mengetahui peran stakeholder dalam pengelolaan  wisata Pantai Air Manis. Penelitian dilakukan dengan metode deskriptif kualitatif. Data diperoleh melalui wawancara, observasi, dan telaah dokumen. Hasil dari penelitian menunjukkan bahwa terdapat dua kategori stakeholder yang terlibat dalam pengelolaan wisata yaitu Dinas Kebudayaan dan Pariwisata, Dinas PU, dan Dishub sebagai stakeholder kunci dan masyarakat lokal sebagai stakeholder primer. Stakeholder kunci berperan sebagai koordinator dan fasilitator dalam mengelola atraksi, akomodasi, aksesibilitas serta informasi dan promosi wisata. stakeholder primer berperan sebagai fasilitator dan pelaksana dalam atraksi, akomodasi serta aksesibilitas wisata. Disbudpar memiliki kapasitas yang rendah karena belum mampu mengcover pengelolaan wisata. Oleh karena itu wisata dicover oleh masyarakat lokal sehingga menyebabkan kondisi atraksi serta fasilitas wisata kurang baik dan kurang terawat.
SEBARAN EMISI CO2 DAN IMPLIKASINYA TERHADAP PENATAAN RUANG AREA INDUSTRI DI KABUPATEN KENDAL
Authors: Labiba Dina , Pradoto Wisnu
Published: September 2019

Kabupaten Kendal adalah wilayah yang memiliki peran sebagai salah satu pusat aktivitas industri di Provinsi Jawa Tengah. Tujuan dari penelitian ini adalah untuk mengetahui sebaran sumber emisi CO2 dari sektor industri serta menganalisis faktor-faktor yang mempengaruhi pertumbuhan emisi tersebut sebagai dasar acuan dalam merumuskan implikasi kebijakan penataan ruang aktivitas industri di Kabupaten Kendal berdasarkan konsep low carbon city. Analisis dilakukan terhadap sembilan aktivitas industri skala besar yang besar tersebar pada tiga kecamatan di Kabupaten Kendal yaitu Kecamatan Kaliwungu, Boja dan Kangkung. Hasil dari analsisis terhadap kadar intensitas produksi emisi CO2 aktivitas industri menunjukkan bahwa industri PT. Sinar Bahari Agung di Kecamatan Kangkung memiliki menghasilkan emisi CO2 tertinggi. Sementara itu untuk hasil dari analisis potensi pertumbuhan pertumbuhan emisi CO2 dilihat dari faktor penghambat dan pemicu pertumbuhan emisi tersebut, menunjukkan bahwa hingga tahun 2031 pertumbuhan emisi CO2 sektor industri di Kabupaten Kendal akan terus mengalami peningkatan. Implikasi kebijakan penataan ruang yang dapat diterapkan adalah penambahan areal ruang terbuka hijau. Penambahan ruang terbuka hijau diprioritaskan pada aktivitas industri pada aktivitas industri PT. Sinar Bahari Agung dan PT. Rimba Partikel Indonesia. Selain itu, implikasi kebijakan lainnya yang dapat diterapkan ialah dengan membatasi pertumbuhan aktivitas industri di wilayah bagian selatan Kabupaten Kendal serta pengoptimalan pemanfaatan lahan industri dengan penerapan Industrial Symbiosis.
Feature fusion to increase the robustness of machine learners in industrial environments
Authors: Holst Christoph-Alexander , Lohweg Volker
Published: September 2019

Industrial applications put special demands on machine learning algorithms. Noisy data, outliers, and sensor faults present an immense challenge for learners. A considerable part of machine learning research focuses on the selection of relevant, non-redundant features. This contribution details an approach to group and fuse redundant features prior to learning and classification. Features are grouped relying on a correlation-based redundancy measure. The fusion of features is guided by determining the majority observation based on possibility distributions. Furthermore, this paper studies the effects of feature fusion on the robustness and performance of classification with a focus on industrial applications. The approach is statistically evaluated on public datasets in comparison to classification on selected features only.
Mechanomyography-based assessment during repetitive sit-to-stand and stand-to-sit in two incomplete spinal cord-injured individuals
Authors: Abd Aziz Musfirah , Hamzaid Nur Azah , Hasnan Nazirah , Dzulkifli Muhammad Afiq
Published: September 2019

Standing up and sitting down movements are important prerequisites to achieve functional independence in everyday life of spinal cord injury (SCI) patients. Thus, mechanomyography (MMG) was proposed as a safe monitoring tool to evaluate muscle function performance of these activities. Two incomplete SCI participants performed repetitive sit-to-stand (SitTS) and stand-to-sit (StandTS) until fatigued challenge. Three sets of these activities were completed with MMG sensors attached over the quadriceps muscles of both legs. A 5-min rest was allocated between each set, totalling 399 trials of SitTS and StandTS activities. There was a significant difference between MMG’s mean root mean square maximum (RMSmax) in SitTS and StandTS activities (p = 0.014). The mean values of RMSmax and root mean square average (RMSave) on the right leg were detected to be significantly higher compared to those of the left leg during these activities (p < 0.05). In the frequency domain, MMG’s mean power frequency (MPF) proved to be significantly higher at the beginning compared to the end of the three sets of both activities (p = 0.000). These muscle performances during both activities can be verified based on the analysis of MMG behaviour in time and frequency domains. Furthermore, this study indicated that MMG can be used as a monitoring tool to identify muscle fatigue throughout a prolonged event.
The haptic and perceptional characteristics of an anthropomorphic curved soft finger structure
Authors: Yuvaraj S. , Malayalamurthi R. , Raja K. Venkatesh
Published: September 2019

In recent decades, modeling of soft fingertips has fascinated a superior momentum in research initiatives concerned with development of an anthropomorphic soft finger tip. In design and development of soft fingertips, analysis of contact a characteristic plays a vital role on dexterous manipulation. This research work presents the results of the experimental investigation in relation to the formulations of contact area for soft fingertips pressed against assorted target profiles. A dimensionless parameter, curve factor Y (r/R) is introduced to derive a parametric relationship among the key parameters. It also addresses the growth of contact area of fingertips for five different combinations. From experimental observations, a modified power law equation with conversion factor (X) is proposed to interpolate the magnitude of contact area for different profiles.
Change in Distillation Column Control Philosophy Using Dynamic Simulation
Authors: Parmar Kanubhai , Dash Sukanta , Patil Sunil , Padmavathi Garimella
Published: September 2019

At condensate stripper of a cracker plant with design control philosophy for composition control pant was facing operational difficulty. Due to disturbance in operating parameter column was becoming unstable and product was getting offspec w.r.t. desired purity. One of the applications of dynamic simulation is to troubleshoot the challenges related to control philosophy in practical application. Since steady-state simulation models cannot predict behavior with respect to time, initially steady state model and finally a dynamic model was developed in Aspen HYSYS. The model is used to study the process behavior for existing control philosophy and proposed philosophy. To avoid column puncture and without waiting for plant shut down the existing Temperature Indicator (TI) considered as Temperature Indicator Controller (TIC) for the study. A new control philosophy was developed based on the response of variables after disturbances in feed rate and composition. The revised control philosophy has been implemented and is now working satisfactorily, providing stabilized operation of the column with consistent bottom product quality. This has helped to reduce the loss of C2s in the bottom stream by about 700 ppm, for savings of about $100,000 USD per year.
Experience, Its Edges, and Beyond
Authors: Davey Nicholas
Published: September 2019

This essay offers a reflection on the notion of experience considered within the context of framework of relational ontology. The primary advantage of such a consideration is that it escapes the consequences of subject-object accounts of experience, accounts which either laud the cognitive subject as master of the experienced world or exile it to an existence in a world it does not experience as its own. Setting experience within a relational ontology and developing a participatory epistemology around the concept offers an inter-active account of experience as an ontological process and an integrated account of knowing and being. This ends the traditional privileging the human as a cognitive subject and opens the way to thinking of all elements within interactive processes as interpretive agencies. Furthermore, it allows the category of interpretation to be freed from the domain of cognitive subjects and to become a descriptor of ontological interaction in general.
Qualität im Kontext der Integrierten Versorgung
Authors: Mayer Peter J.
Published: September 2019

Gewachsene Strukturen bilden die Ausgangslage, Integrierte Gesundheitsversorgung das Ziel. Jede verantwortungsvolle Unternehmerin und jeder verantwortungsvolle Unternehmer hätte den Fokus längst auf die individuellen Versorgungsbedarfe und Bedürfnisse seiner Klientinnen und Klienten gelegt und sämtliche Prozesse bedarfs- und bedürfnisgerecht ausgerichtet. Strukturen haben nur den einen Zweck, die Prozesse bestmöglich zu unterstützen. Für die Gesundheitsversorgung bedeutet dies: Auf allen Ebenen des Gesundheitssystems den Mut aufzubringen, sich ausschließlich an Krankheitsbildern und Versorgungsbedürfnissen zu orientieren, – im Sinne einer gelebten Kultur der Versorgungsqualität.
MDK-Qualitätskontroll-Richtlinie – Instrument zur Qualitätssicherung im Krankenhaus
Authors: Haun Oliver
Published: September 2019

Bisher werden Qualitätsvorgaben, welche anhand von Richtlinien des G-BA erlassen werden, auf Grundlage des § 275 Abs. 4 SGB V durch den MDK geprüft. Die Beauftragung durch die Krankenkassen sowie die nachgelagerte Prüfpraxis gestalten sich je nach Bundesland dabei sehr heterogen. Mit dem Krankenhausstrukturgesetz (KHSG) wurde deshalb Anfang 2016 eine Grundlage geschaffen, um mit der MDK-Qualitätskontroll-Richtlinie nach § 275a SGB V ein systematisches Prüfgeschehen und eine transparente Qualitätssicherung zu gewährleisten.
Measurement of L X-ray production cross sections and relative intensities of some lanthanide compounds depending on the temperature
Authors: Cinan Esra , Aygün Bünyamin , Sayyed M. I. , Özdemir Yüksel
Published: September 2019

L X-ray intensity ratios for CeO2, Sm2(SO4)3, Ho2O3, and Yb2O3 compounds were experimentally investigated. The measurements were gauged following excitation by 59.54 keV γ-rays from a 100 mCi 241Am radioactive annular source at different temperatures in situ. Temperature change occurred between 50 °C and 400 °C. L X-ray emission spectra were obtained by using a solid-state Si(Li) X-ray detector. L X-ray production cross sections, intensity ratios, and full-width half maximum (FWHM) values for the compounds were determined by evaluating the emission spectra varying with the temperature. According to the results obtained, it was observed that L
β1 X-rays were less influenced in comparison with Lα X-rays while Lα X-rays were also less influenced in comparison with Lβ
2 X-rays.
Preparation and characterization of oil palm ash from boiler to nanoparticle
Authors: Bukit Nurdin , Ginting Eva M. , Hutagalung Eveb A. , Sidebang Elfariska , Frida Erna , Bukit Bunga F.
Published: September 2019

This study aims to determine the characteristics of oil palm boiler ash (OPBA) after processing with ball mill and coprecipitation methods. The method used is OPBA from a palm oil mill, processed using a ball mill for 1 hour at a speed of 250 rpm. Then prepared with the coprecipitation method by dissolving it in 2M HCl solution and NaOH solution with variations (2; 2.5; 3) M. Particles were characterized by XRD, SEM, XRF, and FTIR. XRD characterization shows the size of each crystal (83,79; 72,30 and 56,31) nm, with trigonal crystal structure with the SiO2 phase. SEM shows a homogeneous mixture. EDX shows the biggest elements are Si, O and C content. XRF shows the amount of silica is 31.45%. FTIR shows absorption peaks which are the characters of molecular vibrations of the sample.
Altered pain processing and sensitisation is evident in adults with patellofemoral pain: a systematic review including meta-analysis and meta-regression
Authors: Bartholomew Clare , Lack Simon , Neal Bradley
Published: September 2019

Background and aims

Previous systematic reviews have reported manifestations of pain sensitisation as a feature of painful knee disorders, in particular osteoarthritis, with moderate evidence for pain sensitisation in patellofemoral pain (PFP). However, despite past studies recruiting female mostly adolescent PFP patients, it is unclear if sex or age plays a role. Investigation is required to determine if altered pain processing is a key feature of PFP and if a subgroup of patients is at an increased risk to help provide targeted management. The primary aim of this systematic review was to examine evidence investigating pain processing in PFP. Secondary aims were to evaluate the relationship between pain processing and (1) sex, (2) age and (3) symptom duration.

Methods

The protocol was prospectively registered with PROSPERO (CRD42019129851). PubMed, CINAHL, Web of Science and EMBASE were systematically searched from inception to April 2019 for studies investigating pain processing in PFP patients compared to controls using quantitative sensory testing. Each included paper was assessed for methodological quality using a modified version of Downs and Black. Means and standard deviations were extracted to calculate standardised mean differences (SMD) and 95% confidence intervals (95% CI). Where possible meta-analysis and meta-regression were performed using a random effects model.

Results

Eleven studies were identified, two medium and nine high quality. Meta-analysis indicates moderate evidence for decreased pressure pain thresholds (SMD −0.68, 95% CI −0.93 to −0.43), increased tactile detection thresholds (SMD 1.35, 95% CI 0.49–2.22) and increased warmth detection thresholds (SMD 0.61, 95% CI 0.30–0.92) in PFP patients compared to controls. Secondary analysis indicates moderate evidence for decreased pressure pain thresholds in female compared to male patients (SMD −0.75, 95% CI −1.34 to −0.16). Meta-regression indicates a moderate correlation between decreasing local and distal pressure pain thresholds and decreasing patient age (local R2 = 0.556, p = 0.0211; distal R2 = 0.491, p = 0.0354) but no correlation with symptom duration (p > 0.05).

Conclusions

Evidence from this systematic review with meta-analysis and meta-regression appears to suggest the presence of altered pain processing and sensitisation in patients with PFP with increased sensitivity indicated in female patients and younger patients.

Implications

With evidence of altered pain processing and sensitisation in PFP, it may be beneficial for clinicians to consider management approaches that aim specifically at adressing neuropathic pain, for example neuroscience education, to improve patients outcomes. With female patients and younger patients indicated as experiencing greater degree of sensitivity, this may be a good demographic to start screening for sensitisation, in order to better identify and treat those most affected.
Structural studies on dihydropyrimidine derivatives as Mycobacterium tuberculosis coenzyme-A carboxylase inhibitors
Authors: Sallum Lóide O. , Custodio Jean M.F. , Rodrigues Allane C.C. , Ribeiro Jean F.R. , Bezerra Beatriz P. , Ayala Alejandro P. , Ramos Luciana M. , Camargo Ademir J. , Napolitano Hamilton B.
Published: September 2019

A dihydropyrimidine (DHPM) derivative was synthesized, characterized by X-ray diffraction and searched in silico for its inhibitory activities against AccD5 enzyme, the CT domain of a Mycobacterium tuberculosis ACCase. Its molecular structure was compared to another DHPM derivative (DHPM II). The results have shown that the (±)2,6-methano-4-thioxo-3,4,5,6-tetrahydro-2H-[1,3,5] benzoxadiazocines (DHPM I) and (±)2,6-methano-4-oxo-3,4,5,6-tetrahydro-2H-[1,3,5] benzoxadiazocines (DHPM II) belong to the monoclinic and triclinic systems, respectively, and their crystal structures are stabilized by N–H⋯O, O–H⋯O and N–H⋯S interactions. The DHPM derivatives established hydrogen bond interactions with the oxyanion-stabilizing residues (Gly-434/Ala-435) beyond the Thr-217, Phe-394 and Ile-216 in the biotin pocket. The predicted MoB of the DHPM derivatives (21R, 24S, 22R) configuration showed that its phenyl moiety was positioned on the interface between the biotin and propionyl-CoA pockets, suggesting a possible blockade of both subsites. Additionally, the hydrogen bonds involving the O-bridged phenyl ring of the DHPM derivatives (21S, 24R, 22S) configuration with Gly434 in the oxyanion-stabilizing region placed its phenyl moiety in the bottom of the biotin pocket establishing hydrophobic interactions with Leu164, Tyr167, Val459 and Ala155. These results indicate the DHPM derivatives as potential AccD5 inhibitors and promising starting points for future optimizations. Although the overlap of DHPM I and DHPM II did not present significant differences, the exchange of a sulfur atom for an oxygen atom increased the predicted biological potential.
Bench Press at Full Range of Motion Produces Greater Neuromuscular Adaptations Than Partial Executions After Prolonged Resistance Training
Authors: Martínez-Cava Alejandro , Hernández-Belmonte Alejandro , Courel-Ibáñez Javier , Morán-Navarro Ricardo , González-Badillo Juan J. , Pallarés Jesús G.
Published: September 2019

Martínez-Cava, A, Hernández-Belmonte, A, Courel-Ibáñez, J, Morán-Navarro, R, González-Badillo, JJ, and Pallarés, JG. Bench press at full range of motion produces greater neuromuscular adaptations than partial executions after prolonged resistance training. J Strength Cond Res 36(1): 10–15, 2022—Training at a particular range of motion (ROM) produces specific neuromuscular adaptations. However, the effects of full and partial ROM in one of the most common upper-limb exercises such as the bench press (BP) remain controversial. In this study, 50 recreationally to highly resistance trained men were randomly assigned to 1 of 4 training groups: full bench press (BPFULL), two-thirds bench press (BP2/3), and one-third bench press (BP1/3) and control (training cessation). Experimental groups completed a 10-week velocity-based resistance training program using the same relative load (linear periodization, 60–80% 1 repetition maximum [1RM]), only differing in the ROM trained. Individual ROM for each BP variation was determined in the familiarization and subsequently replicated in every lift during training and testing sessions. Neuromuscular adaptations were evaluated by 1RM strength and mean propulsive velocity (MPV). The BPFULL group obtained the best results for the 3 BP variations (effect size [ES] = 0.52–1.96); in turn, partial BP produced smaller improvements as the ROM decreased (BP2/3: ES = 0.29–0.78; BP1/3: ES = −0.01 to 0.66). After 10-week of training cessation, the control group declined in all neuromuscular parameters (ES = 0.86–0.92) except in MPV against low loads. Based on these findings, the BPFULL stands as the most effective exercise to maximize neuromuscular improvements in recreational and well-trained athletes compared with partial ROM variations.
Kesulitan Belajar Mahasiswa pada Materi Aplikasi Integral untuk Luas Daerah dalam Perspektif Disposisi Matematis
Authors: Susilo Bambang Eko , Darhim Darhim , Prabawanto Sufyani
Published: September 2019

Penelitian ini bertujuan untuk mendeskripsikan kesulitan belajar yang dialami mahasiswa pada materi aplikasi integral untuk luas daerah dalam perspektif disposisi matematis. Penelitian ini menggunakan metode deskriptif eksploratif dengan instrumen skala, tes, dokumentasi, dan catatan lapangan. Data diambil dari 80 mahasiswa dari program studi S1 pendidikan matematika di sebuah universitas di Jawa Tengah. Hasil penelitian menunjukkan bahwa mahasiswa dengan disposisi matematis positif sedang dan tinggi memiliki jenis kesulitan yang sama yaitu (1) kesulitan dalam menggambar grafik, (2) kesulitan dalam menentukan daerah yang dicari luasnya, (3) kesulitan dalam menentukan batas integral, (4) kesulitan dalam menggunakan rumus integral, dan (5) kesulitan dalam memahami integral. Mahasiswa dengan disposisi matematis positif rendah selain mengalami kelima kesulitan tersebut, juga mengalami kesulitan dalam menghitung integral. Terdapat tren atau kecenderungan peningkatan persentase pada 2 jenis kesulitan, dan penurunan persentase pada 1 jenis kesulitan, sedangkan pada 3 jenis kesulitan yang lain bersifat fluktuatif.The purpose of this research was to described the learning difficulties experienced by students in integral application material for the area in the perspective of mathematical dispositions. This research used descriptive exploratory methods with scale, tests, documentation, and field notes instruments. Data was taken from 80 undergraduate students from the mathematics education study program at a university in Central Java. The results showed that students with moderate and high positive mathematical dispositions had the same types of difficulties, namely (1) difficulties in drawing graphics, (2) difficulties in determining the area to be searched for, (3) difficulties in determining integral boundaries, (4) difficulties in using integral formulas, and (5) difficulties in understanding integrals. Students with low positive mathematical dispositions in addition to experienced these five difficulties, also experienced difficulties in calculating integrals. There is a trend or tendency to increase percentage in 2 types of difficulties, and a decrease in percentage in 1 type of difficulty, while in 3 other types fluctuating.
A sarcoidosis–lymphoma syndrome revealed by hypopituitarism
Authors: Delcourt Charlotte , Yildiz Halil , Camboni Alessandra , Van den Neste Eric , Roelants Véronique , Kozyreff Alexandra , Thissen Jean Paul , Maiter Dominique , Furnica Raluca Maria
Published: September 2019

A 26-year-old woman presented with persistent headache and tiredness. Biological investigations disclosed a moderate inflammatory syndrome, low PTH-hypercalcemia and complete anterior hypopituitarism. A magnetic resonance imaging (MRI) of the pituitary gland was performed and revealed a symmetric enlargement with a heterogeneous signal. Ophthalmological examination showed an asymptomatic bilateral anterior and posterior uveitis, and a diagnosis of pituitary sarcoidosis was suspected. As the localization of lymphadenopathies on the fused whole-body FDG-PET/computerized tomography (CT) was not evoking a sarcoidosis in first instance, an excisional biopsy of a left supraclavicular adenopathy was performed showing classic nodular sclerosis Hodgkin’s lymphoma (HL). A diagnostic transsphenoidal biopsy of the pituitary gland was proposed for accurate staging of the HL and surprisingly revealed typical granulomatous inflammation secondary to sarcoidosis, leading to the diagnosis of a sarcoidosis–lymphoma syndrome. The co-existence of these diseases constitutes a diagnostic challenge and we emphasize the necessity of exact staging of disease in order to prescribe adequate treatment.

Learning points:

The possibility of a sarcoidosis–lymphoma syndrome, although rare, should be kept in mind during evaluation for lymphadenopathies.

In the case of such association, lymphoma usually occurs after sarcoidosis. However, sarcoidosis and lymphoma can be detected simultaneously and development of sarcoidosis in a patient with previous lymphoma has also been reported.

An accurate diagnosis of the disease and the respective organ involvements, including biopsy, is necessary in order to prescribe adequate treatment.
DrosophilaHeterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary
Authors: Benner Leif , Castro Elias A , Whitworth Cale , Venken Koen J T , Yang Haiwang , Fang Junnan , Oliver Brian , Cook Kevin R , Lerit Dorothy A
Published: September 2019

The small ovary (sov) locus was identified in a female sterile screen, yet its molecular identity and function remained a mystery for decades. In the present work, Benner et al. molecularly map...

Heterochromatin-mediated repression is essential for controlling the expression of transposons and for coordinated cell type-specific gene regulation. The small ovary (sov) locus was identified in a screen for female-sterile mutations in Drosophila melanogaster, and mutants show dramatic ovarian morphogenesis defects. We show that the null sov phenotype is lethal and map the locus to the uncharacterized gene CG14438, which encodes a nuclear zinc-finger protein that colocalizes with the essential Heterochromatin Protein 1 (HP1a). We demonstrate Sov functions to repress inappropriate gene expression in the ovary, silence transposons, and suppress position-effect variegation in the eye, suggesting a central role in heterochromatin stabilization.