bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between daptomycin susceptibility and teicoplanin resistance in Staphylococcus epidermidis
Authors: Watanabe Shinichi , Kawakami Yukinobu , Kimura Hiroshi , Murakami Shinobu , Miyamoto Hitoshi , Takatori Shingo , Suemori Koichiro , Tanaka Mamoru , Tanaka Akihiro , Tanaka Keiko , Tauchi Hisamichi , Maki Jun , Araki Hiroaki , Yamaguchi Takumi
Published: December 2019

Staphylococcus epidermidis infections are a common occurrence in hospitals, particularly in catheter-related bloodstream and surgical site infections and infective endocarditis. Higher daptomycin minimum inhibitory concentration (MIC) values may be associated with daptomycin treatment failure among patients with S. epidermidis infections. We therefore conducted a retrospective cohort study to determine the predictive value of daptomycin susceptibility. A retrospective study was undertaken in 1,337 patients with S. epidermidis infections. Data were collected from 1 January 2013 to 31 December 2016 at Ehime University Hospital, and included the following clinicopathological factors for evaluation: age, sex, resistance to vancomycin or teicoplanin, and history of antimicrobial therapy. Multiple analysis was performed using logistic regression to identify factors that independently and significantly affected the daptomycin resistance. Daptomycin-resistant S. epidermidis was identified in 38 (2.8%) patients. According to the multiple analysis, only higher MIC values (≥16 mg/L) for teicoplanin (P < 0.0001) were independently associated with an increased risk of developing daptomycin resistance. In conclusion, higher teicoplanin MIC values may predict resistance to daptomycin treatment in S. epidermidis infections.
Author Correction: Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
Authors: Altay Gizem , Larrañaga Enara , Tosi Sébastien , Barriga Francisco M. , Batlle Eduard , Fernández-Majada Vanesa , Martínez Elena
Published: December 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publisher Correction: Genome-wide analysis of Corsican population reveals a close affinity with Northern and Central Italy
Authors: Tamm Erika , Di Cristofaro Julie , Mazières Stéphane , Pennarun Erwan , Kushniarevich Alena , Raveane Alessandro , Semino Ornella , Chiaroni Jacques , Pereira Luisa , Metspalu Mait , Montinaro Francesco
Published: December 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
How well can we characterize human serum transformations of magnetic nanoparticles?
Authors: Timerbaev Andrei R.
Published: December 2019

Analytical approaches emerging to fill up the gaps in the characterization of magnetic nanoparticles in human blood are critically discussed.
A nanobiosensor for the simple detection of small molecules using non-crosslinking aggregation of gold nanoparticles with G-quadruplexes
Authors: Chuaychob Surachada , Thammakhet-Buranachai Chongdee , Kanatharana Proespichaya , Thavarungkul Panote , Buranachai Chittanon , Fujita Masahiro , Maeda Mizuo
Published: December 2019

This work demonstrates a simple and specific colorimetric sensor for a hazardous small molecule, cisplatin, using a G-quadruplex (G4) DNA as a sensing probe and non-crosslinking aggregation of gold nanoparticles (AuNPs) as a signal enhancer.
Solvent assisted thermal desorption for the on-site detection of illegal drugs by a miniature ion trap mass spectrometer
Authors: Wang Weimin , Xu Chuting , Ruan Huiwen , Li Hong , Xing Yuming , Hou Keyong , Li Haiyang
Published: December 2019

Schematic diagram of the SFTDPI-ITMS (synchronized flash-thermal-desorption purging and ion injection ion trap mass spectrometer).
Preparation, characterization and evaluation of an imidazolium ionic liquid copolymer stationary phase for mixed-mode chromatography
Authors: Ni Ranxi , Peng Jingdong , Wen Miaomiao , Peng Huanjun , Zhang Zhongying , Li Shiyu , Wang Xiang , Chen Jun , Long Dengying , Xian Hong
Published: December 2019

A novel imidazolium ionic liquid mixed-mode stationary phase (named IBON) was successfully prepared by a controlled thiol-initiated radical polymerization method.
Cobalt-based metal organic frameworks: a highly active oxidase-mimicking nanozyme for fluorescence “turn-on” assays of biothiol
Authors: Jin Tian , Li Yilei , Jing Wenjie , Li Yunchao , Fan Louzhen , Li Xiaohong
Published: December 2019

With Co-MOFs as an oxidase-mimicking nanozyme, the AR oxidized product, non-fluorescent resazurin could be reduced to fluorescent resorufin by l-cysteine, which is specifically applied for fluorescence “turn-on” detection of l-cysteine.
Concise gram-scale synthesis of Euphorikanin A skeleton through a domino ring-closing metathesis strategy
Authors: Shi Linlin , He Yingdong , Gong Jianxian , Yang Zhen
Published: December 2019

Euphorikanin A is a diterpenoid possessing a highly congested and unprecedented 5/6/7/3-fused tetracyclic ring skeleton.
Fused bis-azacalixphyrin that reaches NIR-II absorptions
Authors: Lavaud Lucien , Azarias Cloé , Canard Gabriel , Pascal Simon , Galiana Joachim , Giorgi Michel , Chen Zhongrui , Jacquemin Denis , Siri Olivier
Published: December 2019

The fusion of two azacalixphyrins produces a new class of NIR-II dyes showing an intense absorption band in the 1000–1200 nm NIR range.
Synthesis of superhydrophobic flower-like ZnO on nickel foam
Authors: Wei Xue-Ling , Li Na , An Jun-Fang , Huo Chao-Fei , Liu Huan , Yang RenChun , Li Xingyang , Chao Zi-Sheng
Published: December 2019

Superhydrophobic ZnO flower-like nanostructures with good thermal stability were synthesized on the nickel foam by a combination of hydrothermal and single dip-coating methods.
Correlation between microstructure, cation distribution and magnetism in Ni1−xZnxFe2O4nanocrystallites
Authors: Hölscher Jennifer , Andersen Henrik Lyder , Saura-Múzquiz Matilde , Garbus Pelle Gorm , Christensen Mogens
Published: December 2019

A reliable crystallographic model of Ni1−xZnxFe2O4is presented using a combination of different methods; TEM, STEM-HAADF, and powder diffraction data from different sources (in-house, synchrotron and neutron).
Precipitation of silver particles with controlled morphologies from aqueous solutions
Authors: Wang Lijuan , Andreassen Jens-Petter , Ucar Seniz
Published: December 2019

Mono- and polycrystalline silver particles were formed with morphologies ranging from polyhedral, to hopper, dendritic and spherulitic particles with increasing supersaturation.
Oriented assembly of copper metal–organic framework membranes as tandem catalysts to enhance C–H hydroxyalkynylation reactions with regiocontrol
Authors: Huang Chao , Zhu Kaifang , Lu Guizhen , Zhang Yingying , Wang Dandan , Zhang Dianbo , Mi Liwei , Hou Hongwei
Published: December 2019

The continuous and uniform MOF-based membrane (1a) as a highly efficient heterogeneous catalyst was fabricated on porous Cu foam to significantly outperform bulk crystals1to execute C–H hydroxyalkynylation reactions with regiocontrol.
Design, synthesis and photoinduced processes in molecular interlocked photosynthetic [60]fullerene systems
Authors: Megiatto Jackson D. , Guldi Dirk M. , Schuster David I.
Published: December 2019

The mechanical bond, an entanglement in space between component parts that cannot be separated without breaking or distorting chemical bonds between atoms, can be used as a versatile organizing principle in the design of artificial photosynthetic systems.
Isomeric Co(ii) paraCEST agents as pH responsive MRI probes
Authors: Bond Christopher J. , Cineus Roy , Nazarenko Alexander Y. , Spernyak Joseph A. , Morrow Janet R.
Published: December 2019

Two isomeric Co(ii) paraCEST MRI probes produce a signal correlated to pH in solution and in tissue homogenate.
Facile assembly of layer-interlocked graphene heterostructures as flexible electrodes for Li-ion batteries
Authors: Wang Gang , Chen Guangbo , Yang Sheng , Zhang Panpan , Wang Faxing , Shaygan Nia Ali , Yu Minghao , Feng Xinliang
Published: December 2019

Electrochemically exfoliated graphene–metal oxide hybrids with a unique layer-interlocked structure were assembled and explored as flexible electrodes for Li-ion batteries.
Rapid determination of the original boron isotopic composition from altered basaltic glass by in situ secondary ion mass spectrometry
Authors: He Miaohong , Xia Xiaoping , Huang Xiaolong , Ma Jinlong , Zou Jieqiong , Yang Qing , Yang Fan , Zhang Yanqiang , Yang Yanan , Wei Gangjian
Published: December 2019

Rapid determination of the original boron composition from altered basaltic glass by SIMS boron isotopic profile analysis from the core to rim.
Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles
Authors: Quarta Alessandra , Amorín Manuel , Aldegunde María José , Blasi Laura , Ragusa Andrea , Nitti Simone , Pugliese Giammarino , Gigli Giuseppe , Granja Juan R. , Pellegrino Teresa
Published: December 2019

Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors.
Mechanically and thermo-driven self-healing polyurethane elastomeric composites using inorganic–organic hybrid material as crosslinker
Authors: Yang Shiwen , Wang Shuang , Du Xiaosheng , Cheng Xu , Wang Haibo , Du Zongliang
Published: December 2019

Self-healable, recyclable, and robust polyurethane elastomeric composites by thermally driven Diels–Alder chemistry using inorganic–organic hybrid material as crosslinker.
The hydroxy-analogue of selenomethionine alleviated lipopolysaccharide-induced inflammatory responses is associated with recover expression of several selenoprotein encoding genes in the spleens of Kunming mice
Authors: Tang Jia-Yong , Wang Long-Qiong , Jia Gang , Liu Guang-Mang , Chen Xiao-Ling , Tian Gang , Cai Jing-Yi , Shang Hai-Ying , Zhao Hua
Published: December 2019

This study aimed to determine whether hydroxy-analogue of selenomethionine (HMSeBA) supplementation could alleviate LPS-induced immunological stress in mice.
Directional and velocity control of active droplets using a rigid-frame
Authors: Yamada Masato , Shigemune Hiroki , Maeda Shingo , Sawada Hideyuki
Published: December 2019

This paper introduces a novel directional control method of self-propelled oil droplets using an exoskeleton frame.
A novel indole-based conjugated microporous polymer for highly effective removal of heavy metals from aqueous solution via double cation–π interactions
Authors: Wang Qiang , Li Rui , Ouyang Xiao , Wang Guojun
Published: December 2019

A novel indole-based conjugated microporous polymer (PTIA) with three coplanar indole units, designed and synthesized by an oxidative coupling reaction, was utilized as a platform for removing heavy metals.
A simple strategy to prepare a layer-by-layer assembled composite of Ni–Co LDHs on polypyrrole/rGO for a high specific capacitance supercapacitor
Authors: Kulandaivalu Shalini , Hussein Mohd Zobir , Mohamad Jaafar Adila , Mohd Abdah Muhammad Amirul Aizat , Azman Nur Hawa Nabilah , Sulaiman Yusran
Published: December 2019

A facile and novel electrode material of nickel–cobalt layered double hydroxides (Ni–Co LDHs) layered on polypyrrole/reduced graphene oxide (PPy/rGO) is fabricated for a symmetrical supercapacitor via chemical polymerization, hydrothermal and vacuum filtration.
Photoresponsive behavior of hydrophilic/hydrophobic-based novel azobenzene mesogens: synthesis, characterization and their application in optical storage devices
Authors: B. N. Sunil , Yam Wan Sinn , Hegde Gurumurthy
Published: December 2019

Effect of Photoresponsive behaviour of hydrophilic/hydrophobic based novel azobenzene's. Powerful structure property relationship. Light plays the dominant role in photoisomerization properties.
Organic-nanoclay composite materials as removal agents for environmental decontamination
Authors: Cavallaro Giuseppe , Lazzara Giuseppe , Rozhina Elvira , Konnova Svetlana , Kryuchkova Marina , Khaertdinov Nail , Fakhrullin Rawil
Published: December 2019

Here we overview the recent advances in the fabrication of sustainable composite nanomaterials with decontamination capacity towards inorganic and organic pollutants.
Novel entry to the synthesis of (S)- and (R)-5-methoxycarbonylhydroxymethyluridines – a diastereomeric pair of wobble tRNA nucleosides
Authors: Borowski Robert , Dziergowska Agnieszka , Sochacka Elzbieta , Leszczynska Grazyna
Published: December 2019

Two novel methods for the preparation of the virtually equimolar mixtures of (S)- and (R)-diastereomers of 5-methoxycarbonylhydroxymethyluridine (mchm5U) have been developed.
A general method for site-selective Csp3–S bond formation via cooperative catalysis
Authors: Qin Yuman , Han Yujie , Tang Yongzhen , Wei Junfa , Yang Mingyu
Published: December 2019

A copper-catalyzed site-selective thiolation of Csp3–H bonds of aliphatic amines was developed. The method features a broad substrate scope and good functional group tolerance.
In situ formation of a LiF and Li–Al alloy anode protected layer on a Li metal anode with enhanced cycle life
Authors: Wang Lili , Fu Shiyang , Zhao Teng , Qian Ji , Chen Nan , Li Li , Wu Feng , Chen Renjie
Published: December 2019

Development of next-generation high-energy lithium (Li) metal batteries is hindered by uncontrollable growth of Li dendrites and the unstable Li/electrolyte interface during repeated Li plating/stripping.
Interlayer separation in hydrogen titanates enables electrochemical proton intercalation
Authors: Fleischmann Simon , Sun Yangyunli , Osti Naresh C. , Wang Ruocun , Mamontov Eugene , Jiang De-en , Augustyn Veronica
Published: December 2019

Interlayer structural protons in H2Ti3O7 are identified as the key structural feature to enable electrochemical proton intercalation beyond the near-surface because they effectively reduce interconnections of the titanate layers.
Rational design of polar/nonpolar mediators toward efficient sulfur fixation and enhanced conductivity
Authors: Chen Zihe , Zhang Zexian , Liu Chengcheng , Jiang Cheng , Mei Tao , Wang Xianbao , Qian Yitai
Published: December 2019

Schematic of the classification of polar and nonpolar materials for LSBs.
Functional protein shells fabricated from the self-assembling protein sheets of prokaryotic organelles
Authors: Bari Naimat K. , Kumar Gaurav , Hazra Jagadish P. , Kaur Simerpreet , Sinha Sharmistha
Published: December 2019

Fabricating single component protein compartments from the shells proteins of bacterial microcompartments.
Platinum ions mediate the interactions between DNA and carbon quantum dots: diagnosis of MRSA infections
Authors: Li Han-Wei , Mao Ju-Yi , Lien Chia-Wen , Wang Chu-Kuei , Lai Jui-Yang , Mandal Ranju Prasad , Chang Huan-Tsung , Chang Lung , Ma David Hui-Kang , Huang Chih-Ching
Published: December 2019

The isothermal amplification products ofmecAandfemAgenes induce the fluorescence quenching of platinum ions-capped carbon quantum dots to allow the specific identification of methicillin-resistantStaphylococcus aureus.
A paper-based SERS assay for sensitive duplex cytokine detection towards the atherosclerosis-associated disease diagnosis
Authors: Li Chunxia , Liu Yuan , Zhou Xiaoyan , Wang Yuling
Published: December 2019

Novel SERS based sensing assay was built by combining nanoporous membrane with sandwich immunoassay for duplex cytokines detection. It can be used as a promising candidate for clinical application due to its excellent performance in human serum.
Macroscopic chirality of twist-bend nematic phase in bent dimers confirmed by circular dichroism
Authors: Stevenson Warren D. , Zeng Xiangbing , Welch Chris , Thakur Anil K. , Ungar Goran , Mehl Georg H.
Published: December 2019

Long-range global chirality is confirmed in the twist-bend nematic phase of bent dimers using circular dichroism spectroscopy. The phase absorbs left and right circularly polarized light differently, confirming its helical rather than wavy character.
Accurate tuning of rare earth metal–organic frameworks with unprecedented topology for white-light emission
Authors: Wang Yutong , Zhang Kai , Wang Xiaokang , Xin Xuelian , Zhang Xiurong , Fan Weidong , Xu Ben , Dai Fangna , Sun Daofeng
Published: December 2019

An unprecedented three-dimensional (3D) (3,4,5)-czkf topological framework (UPC-38) with one-dimensional (1D) chain secondary building units exhibits strong white light emission.
Carbon dot-sensitized urchin-like Ti3+ self-doped TiO2 photocatalysts with enhanced photoredox ability for highly efficient removal of Cr6+ and RhB
Authors: Shi Cai , Qi Houjuan , Sun Zhe , Qu Keqi , Huang Zhanhua , Li Jian , Dong Mengyao , Guo Zhanhu
Published: December 2019

Carbon dot-sensitized Ti3+ self-doped dual-phase hierarchical titania composite photocatalysts showed enhanced photoredox ability for removing both heavy metals and organics.
Designing highly fluorescent, arylated poly(phenylene vinylene)s of intrinsic microporosity
Authors: Rodrigues Ana Clara B. , Geisler Isabell S. , Klein Patrick , Pina João , Neuhaus Fabian J. H. , Dreher Elke , Lehmann Christian W. , Scherf Ullrich , Seixas de Melo J. Sérgio
Published: December 2019

The design of new arylated poly(phenylene vinylene) with high fluorescence efficiency (from AIE) and intrinsic microporosity (from SBET) is described.
Inductorless CTLE for 20 Gb/s SerDes for 5G backhaul
Authors: Gaggatur J.S. , Thulasiraman D.
Published: December 2019

A low‐power 3‐stage continuous time linear equalisation (CTLE) was designed in 28 nm CMOS technology for a high speed SerDes in a 5G backhaul. The CTLE active inductor is a transconductance‐based, for high‐frequency operation and for area reduction. The active inductor can be tuned around 10 GHz while consuming 11.17 mW from 0.9 V power supply. The CTLE compensates about 19.5 dB of attenuation due to the channel at a data rate of 20 Gb/s per link, with a power efficiency of 18.6 fJ/bit/dB, which is better power efficiency than the previous works reported in the literature.
Focal length of a low permittivity plano‐convex lens at frequencies 30–600 GHz
Authors: Kokkonen M. , Myllymäki S. , Jantunen H.
Published: December 2019

Due to interest in lenses at telecommunicatons in the lower frequency range of 30–600 GHz (5G/6G applications) sub‐terahertz range lenses have started to make their appearance. Geometrical optics is typically used due to its faster calculation speed, which is faster than finite element methods (FEMs). A 30‐mm plano‐convex lens was simulated with a COMSOL ray tracing module and CST was used to simulate 30, 60, 300 and 600 GHz FEM simulations. Focal points were 248, 189, 180, 118 and 131 mm with CST and 253 mm with COMSOL.
Stability analysis and stabilisation of delayed IT2 fuzzy systems based on the Bessel–Legendre inequality
Authors: Li Jingjing , Zhou Shaosheng
Published: December 2019

This study is concerned with the problems of asymptotic stability analysis and stabilisation for interval type‐2 (IT2) fuzzy systems with time‐varying delays. An augmented Lyapunov–Krasovskii functional including triple‐integral terms is constructed. By the second‐order Bessel–Legendre integral inequality and the reciprocally convex combination, a good estimation of the derivative for the Lyapunov–Krasovskii functional can be derived. Thus, sufficient asymptotic stability conditions for the delayed IT2 fuzzy system are established. The proposed method provides improvements and produces better results than the existing ones in the literature. Furthermore, in light of Finsler's lemma and the obtained asymptotic stability conditions, a state feedback controller for the delayed IT2 fuzzy system is developed. Finally, three numerical examples are given to illustrate the effectiveness of the proposed results.
Transformer‐less single‐phase unified power quality conditioner of no circulating current
Authors: Xu Congqian , Zhou Min , Liu Yonglu , Sun Yao
Published: December 2019

This study presents a unified current‐source power quality conditioner of inherent no circulating current. It is formed of a three‐leg current‐source ac/ac converter and a specially designed small size dc‐link. Owing to the transformers‐less feature and small size dc‐link, the proposed topology has the benefit of high power density. In addition, without the need to address the circulating current issue, it is easier to design the controllers and filters for the circulating current compared to other existing transformer‐less unified power quality conditioners. To handle the harmonic currents compensation, voltage sags/swells elimination, power factor correction simultaneously and achieve excellent dynamic and steady‐state performance, a direct control method based on an extended repetitive disturbance observer is proposed. Detailed analysis of topology and operation principles is given, followed by the modulation scheme and the developed control method. Simulations and experimental results are presented to verify the effectiveness of the conditioner.
Rebound behaviour of uncoordinated EMS and their impact minimisation
Authors: Mahmud Khizir , Ravishankar Jayashri , Hossain Jahangir
Published: December 2019

In this paper, the impacts of uncoordinated energy management systems (EMS), with a rebound effect, on a renewable energy‐dependent microgrid are discussed and feasible solutions are presented. Two different approaches, i.e. load‐based and price‐based EMS are modelled which consider PV units, battery energy storage systems (BESS), and electric vehicles (EVs). Taking account of each component's boundary conditions, the load‐based approach intelligently charges the EV and BESS from the grid/PV during off‐peak hours, and provides a combined discharge response during peak load hours. In the price‐based approach, the charging‐discharging of BESSs and EVs from/to grid and PV depends on the time‐of‐use tariff signal. The primary objective of both models is to minimise the customers' peak electricity consumption and the saturation issues of distribution transformers. It is observed that the simultaneous response of the EMS due to the identical behaviour of load or price curves, and the rebound effect after mode switching transition create large power demand spikes. To mitigate its negative consequence, an improved locking and randomisation technique is designed and implemented. Additionally, the impact of the PV power fluctuations on the load‐support systems due to fast‐moving clouds and their consequences to the behaviour of the EMS response are investigated.
Two‐stage restoration strategies for power systems considering coordinated dispatch between plug‐in electric vehicles and wind power units
Authors: Zhang Can , Zhang Huayi , Liu Shengyuan , Lin Zhenzhi , Wen Fushuan
Published: December 2019

With increased penetration of wind power units and plug‐in electric vehicles (PEVs), their control flexibility and quick response potentially provide an alternative way to fulfil the need for rapid restoration. A two‐stage restoration strategy optimisation approach is presented with the coordination of PEVs and wind power units considered. The optimisation model is to maximise the restored generation capability and minimise the fluctuation of cranking power. In the first stage, the aim is to provide reliable cranking power remotely for black start generators through coordinated dispatch of PEVs and wind power units and quadratic programming (QP) models for dispatching electric vehicle aggregators (EVAs) subject to wind power fluctuations, and for dispatching numerous PEVs within each EVA are developed. To ensure close coordination between these two dispatching procedures, bi‐level programming‐based hierarchical decomposition approach is used to solve the QP models in an iterative way. In the second stage, an integer linear programming model is proposed to optimise the restoration schedules through an effective transformation of the original non‐linear formulation, so as to reduce the computing time and effort significantly. Finally, a case study is presented to demonstrate the effectiveness and essential features of the developed models and methods.
Resilience of the electric distribution systems: concepts, classification, assessment, challenges, and research needs
Authors: Kandaperumal Gowtham , Srivastava Anurag K.
Published: December 2019

Distribution system resilience is an emerging topic of interest given an increasing number of extreme events and adverse impacts on the power grid (e.g. Hurricane Maria and Ukraine cyber‐attack). The concept of resilience poses serious challenges to the power system research community given varied definitions and multivariate factors affecting resilience. The ability of nature or malicious actors to disrupt critical services is a real threat to the life of our citizens, national assets and the security of a nation. Many examples of such events have been documented over the years. Promising research in this area has been in progress focused on the quantification and in enabling resilience of the distribution system. The objective of this study is to provide a detailed overview of distribution system resilience, the classification, assessment, metrics for measuring resilience, possible methods for enabling resilience, and the associated challenges. A new multi‐dimensional and multi‐temporal resilience assessment framework is introduced along with a research roadmap outlining the future of resilience to help the reader conceptualise the theories and research gaps in the area of distribution system cyber‐physical resilience.
Electric power grid resilience with interdependencies between power and communication networks – a review
Authors: Liu Xin , Chen Bo , Chen Chen , Jin Dong
Published: December 2019

Because of the development of smart grid technology, today's power grid infrastructures are increasingly and heavily coupled with communication networks for many new and existing power applications. The interdependent relationship between the two systems, in which power control relies on the communication system to deliver control and monitoring messages and network devices require power supplies from the electrical grid, brings challenges in the effort to build a highly resilient integrated infrastructure. In this work, the authors summarise existing research on power grid resilience enhancement with the consideration of the interdependencies between power systems and communication networks. They categorise these works according to stages of resilience enhancement (i.e. failure analysis, vulnerability analysis, failure mitigation, and failure recovery) and methodologies (i.e. analytical solutions, co‐simulation, and empirical studies). They also identify the limitations of existing works and propose potential research opportunities in this demanding area.
Performance evaluation of CoAP proxy virtualisation in cloud‐assisted sensor networks
Authors: Banaie Fatemeh , Hosseini Amin , Yaghmaee Mohammad Hossein
Published: December 2019

In this study, the authors have modelled the performance of a scalable proxy virtualisation framework to support an appropriate level of quality of service (QoS) for delay sensitive applications in cloud‐based large‐scale sensor networks. The proposed model leverages the functionalities of a constrained application protocol (CoAP) to expose a standard interface for transparently decoupling of the applications from servers and ensuring the implementation of the custom QoS metrics through virtualisation techniques. The model, combined with the prediction‐based dynamic resource allocation approach, enables the computation of the number of requests that can be supported for a given service rate and required QoS. It also features the evaluation of different performance metrics, particularly, the probability distribution of the response time and the ability to identify the optimal balance between the resource cost and the service performance. The numerical results obtained from the proposed analytical model can be used to help design and optimise industrial cloud‐based sensing systems.
Innovative technologies in training and education for maintenance team of NPPs
Authors: Soós Róbert , Balogh Bence , Dobos Gergely , Szávai Szabolcs , Dudra Judit
Published: December 2019

Many industries, such as nuclear power plants, chemical industry, oil and gas industry have dangerous working environments and hazardous conditions for employees. Maintenance, inspection and decommissioning activities in these safety-critical areas mean a serious risk, downtime is a significant financial loss. The Virtual Reality Training Platform is reflecting on this shortcoming, by providing the possibility for maintenance workers to be trained and prepared for unexpected scenarios, and to learn complex maintenance protocols without being exposed to unnecessary danger, like high temperature, radiation, etc. Employees can have training for equipment maintenance, dismantling of facilities at closed NPP Units. One of the most significant and unique added value of the immersive virtual reality solution is that the operator can experience lifelike emergencies (detonation, shutdown) under psychological pressure, while all of the physiology indicators can be monitored like eye-tracking. Users can work together anywhere in the world. A huge financial outage in industrial production is the preparation and maintenance downtime, which can be significantly reduced by the Virtual Training platform. This method can increase the accuracy, safety, reliability, and accountability of the maintenance and decommissioning procedures, while operational costs can be reduced as well.
A slacks-based measure approach for efficiency decomposition in multi-period two-stage systems
Authors: Esfidani Samaneh , Hosseinzadeh Lotfi Farhad , Razavyan Shabnam , Ebrahimnejad Ali
Published: December 2019

Two-stage production systems are often encountered in many real applications where the production process is divided into two processes. In contrast to the conventional data envelopment analysis (DEA) models, two-stage DEA models take the operations of the internal processes into account. A number of studies have used two-stage DEA models in order to evaluate the performance of decision making units (DMUs) having a network structure. In this paper, we use a non-radial DEA model called the network slacks-based measure (NSBM) model to measure the efficiency of a system with a multi-period two-stage structure. Then we describe the properties of the proposed model in details. Moreover, we shall decompose the overall efficiency of the system over a number of time periods as a weighted average of the efficiency in each period. The efficiency of the stages, in respect to the entire periods shall be decomposed in terms of the weighted average efficiency of the stages in each period. Finally, the real data of Mellat bank branches in Tehran extracted from extant literature is used to illustrate the proposed approach.
Update zur bildgebenden Diagnostik bei Patienten mit Großgefäßvaskulitis
Authors: Klink Thorsten , Bley Thorsten A.
Published: December 2019

Die Großgefäßvaskulitis umfasst die häufigere und oft bei älteren Patienten vorkommende Riesenzellarteriitis und die häufiger bei jüngeren Patientinnen auftretende Takayasu-Arteriitis. Die Bildgebung ist bei diesen Vaskulitiden sowohl für die Primärdiagnostik als auch bei Folgeuntersuchungen wichtig und wird im Folgenden differenziert dargestellt.
Aktuelle Aspekte der Cholesteatomchirurgie – Teil 1: Grundlagen und Diagnostik
Authors: Schulze Anja , Zahnert Thomas
Published: December 2019

Das Cholesteatom als chronische Entzündung des Mittelohrs führt zu einer fortschreitenden knöchernen Destruktion des Felsenbeins. Leitsymptome sind fötide Otorrhö, Schwerhörigkeit und Schwindel. Unbehandelt kann das Cholesteatom durch intrakranielle Komplikationen letal verlaufen. Es folgt eine Darstellung des aktuellen und allgemein anerkannten Kenntnisstandes zur Genese, Klinik und präoperativen Diagnostik. Ausführungen zur operativen Therapie folgen in einem 2. Teil.
Verdacht auf Hippocampussklerose bei einer Europäisch-Kurzhaar-Katze mit der Diagnose Polycythaemia
vera
Authors: Kempf Jennifer , von Magnis Johannes
Published: December 2019

Bei einer 7-jährigen männlich-kastrierten Europäisch-Kurzhaar-Katze, vorgestellt aufgrund von akut reduziertem
Allgemeinbefinden und einer vestibulären Ataxie, wurde die Diagnose Polycythaemia vera gestellt. Im weiteren Verlauf
zeigte die Katze intermittierend orofaziale Zuckungen, Aggressivität, Speicheln, Kreiswandern und Kopfschiefhaltung. Bei
der weiterführenden Diagnostik mittels Magnetresonanztomografie ließen sich Veränderungen im Bereich des Hippocampus
nachweisen, die mit einer Hippocampussklerose vereinbar waren. Der Fallbericht beschreibt zum einen die klinischen und
hämatologischen Befunde einer Polyzythämie und den Krankheitsverlauf während der Therapie. Zum anderen wird der
Zusammenhang zur Hippocampusveränderung diskutiert. Diese könnte sekundär zu einer durch die Polyzythämie verursachten
zerebralen Hypoperfusion entstanden sein.
Leitfaden Ernährungstherapie in Klinik und Praxis (LEKuP)
Authors: Hauner Hans , Beyer-Reiners Evelyn , Bischoff Gert , Breidenassel Christina , Ferschke Melanie , Gebhardt Albrecht , Holzapfel Christina , Lambeck Andrea , Meteling-Eeken Marleen , Paul Claudia , Rubin Diana , Schütz Tatjana , Volkert Dorothee , Wechsler Johannes , Wolfram Günther , Adam Olaf
Published: December 2019

Der Leitfaden Ernährungstherapie in Klinik und Praxis (LEKuP) stellt eine grundlegende Überarbeitung des zuletzt im Jahr 2004 von der Deutschen Akademie für Ernährungsmedizin e. V. (DAEM) herausgegebenen Rationalisierungsschemas dar. Dabei erfolgte die Erstellung des LEKuP in enger Zusammenarbeit der verschiedenen Fachgesellschaften: Deutsche Gesellschaft für Ernährung e. V. (DGE) und die Deutsche Akademie für Ernährungsmedizin e. V. (DAEM) mit der Deutschen Gesellschaft für Ernährungsmedizin e. V. (DGEM), dem Berufsverband Deutscher Ernährungsmediziner e. V. (BDEM), der Deutschen Adipositas-Gesellschaft e. V. (DAG), dem Verband der Diätassistenten – Deutscher Bundesverband e. V. (VDD) und dem Berufsverband Oecotrophologie e. V. (VDOE).

Gemeinsames Ziel der beteiligten Fachgesellschaften und -verbände war es, auf Grundlage evidenzbasierter Leitlinien einen aktuellen und konsensbasierten Leitfaden für die praktische Ernährungstherapie in Klinik und Praxis zu verfassen. Ein weiteres Ziel der Überarbeitung war es, damit eine Vorlage zu schaffen, aus der ein Kostformenkatalog für stationäre und ambulante medizinische Einrichtungen nach den lokalen Bedürfnissen abgeleitet werden kann.

Die dem LEKuP zugrunde liegenden Empfehlungen basieren auf den D-A-CH-Referenzwerten für die Nährstoffzufuhr der Deutschen Gesellschaft für Ernährung e. V. (DGE) für Erwachsene und entsprechen einer vollwertigen und gesundheitsförderlichen Ernährung. Mittelmeerkost und vegetarische Ernährung werden als gleichwertig betrachtet. Abhängig von krankheitsspezifischen Erfordernissen werden Abweichungen und Ergänzungen vorgenommen, sodass eine Ernährungstherapie umgesetzt werden kann, die alle ernährungsbezogenen Maßnahmen zur Wiederherstellung von Gesundheit und Wiedererlangung des Handlungsvermögens von Patienten darstellt. Der vorliegende Leitfaden beschränkt sich auf die Darstellung der Prinzipien der Ernährungstherapie und deren praktische Umsetzung.
Effektivität von topischem Oclacitinib mit und ohne Tacrolismus bei kaniner Keratoconjunctivitis
sicca
Authors: Betz Daniela Simon
Published: December 2019

Kravetz de Oliveira J, Williams DL, Bollmann C et al. Comparative efficacy of topical oclacitinib 0.1 % and tacrolimus
0.01 % in canine keratoconjunctivitis sicca. Vet Ophthalmol 2019; 22: 633–643

Keratoconjunctivitis sicca (KCS) ist eine meist autoimmun bedingte Erkrankung des Hundes, die mit einer entzündlichen
Infiltration und nachfolgender Atrophie der Tränendrüsen einhergeht. Hierdurch kommt es zu einer Reduktion der
Tränenproduktion mit chronischer Entzündung des Auges und entsprechendem negativem Einfluss auf die Lebensqualität
der Patienten. Ziel dieser Studie war, die Effektivität des Oclacitinib (ein für die Behandlung von
allergiebedingtem Juckreiz zugelassener Januskinase-Inhibitor) allein oder in Kombination mit der klassischen
immunmodulatorischen Therapie mit Tacrolismus zu untersuchen.
Sportliche Leistung von Pferden, die als Fohlen intensivmedizinischer Behandlung
bedurften
Authors: Demattio Lukas
Published: December 2019

Studies AC, Chidlow H, Ere SG et al. Factors associated with long-term athletic outcome in Thoroughbred neonates admitted
to an intensive care unit. Equine Vet J 2019; 51: 716–719

Für viele Pferdezüchter stellt sich immer wieder die Frage, wie viel Geld in ein Fohlen investiert werden soll, wenn
dieses tierärztlicher Behandlung bedarf. Lohnt sich eine intensivmedizinische Behandlung für ein Fohlen, das für
eine sportliche Nutzung vorgesehen ist? Diese Frage versuchten die Autoren in der Studie zu beantworten.
Endoskopische Vasektomie beim Hengst
Authors: Nieth Jennifer
Published: December 2019

Vitoria A, Romero A, Fuenta S et al. Application of a laparoscopic technique for vasectomy in standing horses. Vet Rec
201; 185 (11): 345

Bei der Vasektomie wird der Ductus deferens abgebunden und ein Anteil entfernt. Es resultiert eine Azoospermie bei
Erhaltung des hormonell bedingten Verhaltens und der Auswirkungen auf die körperliche Entwicklung. Dieser Eingriff
ist als konventionell chirurgische und als minimalinvasiv endoskopische Operationsmethode in der Humanmedizin
verbreitet und in der Tiermedizin bei verschiedenen Spezies beschrieben. Ziel der Studie war, diesen Eingriff beim
Pferd erstmals zu beschreiben und ihren Erfolg zu bewerten.
Correlation between the Expression of Interleukin-6, STAT3, E-Cadherin and N-Cadherin Protein and Invasiveness in Nonfunctional Pituitary Adenomas
Authors: Shen Xiaoxu , Liu Qi , Xu Jian , Wang Yang
Published: December 2019

Objective This study aimed to investigate the expression of interleukin (IL)-6, signal transducer and activator of transcription 3 (STAT3), epithelial-cadherin (E- cadherin) and neural-cadherin (N-cadherin) proteins in nonfunctional pituitary adenomas, and their correlation with invasiveness.

Methods Thirty cases of nonfunctional pituitary adenoma pathological wax specimens were selected from our hospital, including 20 cases of invasive nonfunctional pituitary adenoma (INFPA) and 10 noninvasive nonfunctional pituitary adenomas (NNFPAs). Envision was used to detect IL-6, STAT3, E-cadherin , and N-cadherin in specimens. Statistical methods were used to analyze the correlation between the four proteins and the Knosp classification of nonfunctional pituitary adenomas.

Result IL-6 and STAT3 were highly expressed in INFPAs but poorly expressed in NNFPAs. E-cadherin expression in INFPAs was lower than that in NNFPAs. N-cadherin was positive or strongly positive in both groups. Spearman's correlation analysis showed that the expression of IL-6 and STAT3 was positively correlated with Knosp's classification, whereas the expression of E-cadherin was negatively correlated with Knosp classification. Meanwhile, the expression of N-cadherin was not correlated with Knosp's classification.

Conclusion The expression of the IL-6, STAT3, E-cadherin proteins were associated nonfunctional pituitary adenomas. However, the expression of N-cadherin was not correlated with nonfunctional pituitary adenomas.
Dependence of radiation decay constant of laser produced copper plasma on focal position
Authors: Junjuri Rajendhar , Rashkovskiy Sergey A. , Gundawar Manoj Kumar
Published: December 2019

Laser-induced copper plasma is investigated experimentally and theoretically. Laser-induced plasma on the surface of the copper sample is generated by focusing a nanosecond (∼7 ns) laser pulse. The experiment is performed in the ambient atmosphere at three different focal positions (lens to sample distances). The main objective of this work is to investigate the effect of the focal position on the radiation decay constant of the plasma. Experimental data are used for estimating the plasma temperature, electron density, ablated mass, and radiation decay constant. It is shown that these parameters essentially depend on the focal position with respect to the sample surface. The theory of relaxation of radiation is considered for the kinetic evolution of the plasma. The results of the theory are compared with the obtained experimental data.
A comprehensive study of the uncertainties in bolometric tomography on JET using the maximum likelihood method
Authors: Peluso E. , Craciunescu T. , Murari A. , Carvalho P. , Gelfusa M. ,   JET Contributors
Published: December 2019

Essential physical quantities of magnetically confined plasmas are derived on a routine basis from bolometric reconstructions. In the last few years at the Joint European Torus (JET), the Maximum Likelihood method has demonstrated the capability of providing reliable reconstructions for this class of ill-posed problems. The article is focused on quantifying the effects of important sources of errors, usually underestimated, that can influence both the reconstructions and the derived quantities. A complete set of phantoms has been used to test the robustness of the technique. The main sources of uncertainties investigated in this contribution are random noise, presence of outliers in the measurements, uncertainty of the position of the magnetic topology, and missing measurements from damaged or unreliable bolometers. The study provides a comprehensive quantification of the uncertainties to associate with most typical emissivities encountered in practice and constitutes a good basis for a more accurate evaluation of the power balances on the JET.
Sparse defects detection and 3D imaging base on electromagnetic tomography and total variation algorithm
Authors: Wang Qi , Li Kun , Zhang Ronghua , Wang Jianming , Sun Yunkuan , Li Xiuyan , Duan Xiaojie , Wang Huaxiang
Published: December 2019

Metal products are widely used in the industrial field. However, internal defects such as holes, dents, and scratches are prone to occur due to factors such as processing, production equipment failure, and poor working conditions. Electromagnetic tomography (EMT) is an effective method for defects imaging. Nevertheless, metal defects are prone to be small and sparsely distributed on the surface or inside so that image reconstruction for metal defects based on EMT is still challenging. In this paper, the sparse regularization method is used for a mathematical model of EMT reconstruction in order to improve the image quality. According to the relationship between the detection depth and the excitation frequency, three-dimensional reconstructed images are used for the surface and internal defects of the metal parts. Both simulations and experiments are carried out to verify the effectiveness of the method.
Time-resolved thermally induced aberrations in a flash-lamp pumped Nd:Glass disk amplifier using a 2 × 2 position sensitive detector array
Authors: Ahmad M. , Galletti M. , Oliveira P. , Dilworth E. , Robinson D. J. , Galimberti M. , Crawford A. J. , Musgrave I. , Esser M. J. D.
Published: December 2019

A novel technique of measuring the prompt, thermally induced wave-front aberrations in a large aperture flash-lamp pumped Nd3+ glass disk amplifier is presented. Implementing a 2 × 2 lens array and a 2 × 2 position sensitive detector array as a diagnostic system, the wave-front profile was successfully reconstructed for the first five Zernike terms for a temporal window of 8.5 ms.
Impact of divertor plasma parameters on characteristics of current-convective turbulence under DIII-D-like detached conditions
Authors: Stepanenko A. A. , Wang H. Q. , Krasheninnikov S. I.
Published: December 2019

Recent observations of turbulence in plasma of a DIII-D inner divertor revealed the formation of poloidally localized fluctuations with frequencies in the low-kilohertz range, when the machine was operating in the fluctuating state of detachment. This phenomenon can be related to the onset of the current-convective instability (CCI). In this contribution, we use the basic physical model of the instability to simulate the saturated current-convective turbulence under the DIII-D-like detached conditions. Parameter scans of turbulence characteristics are performed. The spatial and temporal spectra of fluctuations are obtained and compared with the available experimental data. It is demonstrated that simulations are able to qualitatively reproduce most of the distinct features of turbulence found in the experiments, indicating that the CCI can be a plausible mechanism responsible for plasma activity recently observed in DIII-D.
Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow
Authors: Algarni Abdulrahman , Greenman John , Madden Leigh A.
Published: December 2019

Tumor patients are at a high risk of venous thromboembolism (VTE), and the mechanism by which this occurs may involve tumor-derived microvesicles (MVs). Previously, it has been shown that tumor MVs become attached to endothelial cells in static conditions. To investigate whether this process occurs under physiologically relevant flow rates, tumor MVs were perfused across a microfluidic device coated with growing human umbilical vein endothelial cells (HUVECs). Cell lines were screened for their ability to form tumor spheroids, and two cell lines, ES-2 and U87, were selected; spheroids formed were transferred to a microfluidic chip, and a second endothelial cell biochip was coated with HUVECs and the two chips were linked. Media flowed through the spheroid chip to the endothelial chip, and procoagulant activity (PCA) of the tumor media was determined by a one-stage prothrombin time assay. Tumor MVs were also quantified by flow cytometry before and after interaction with HUVECs. Confocal images showed that HUVECs acquired fluorescence from MV attachment. Labeled MVs were proportionally lost from MV rich media with time when flowed over HUVECs and were not observed on a control chip. The loss of MV was accompanied by a proportional reduction in PCA. Flow cytometry, confocal microscopy, and live flow imagery captured under pulsatile flow confirmed an association between tumor MVs and HUVECs. Tumor MVs attached to endothelial cells under physiological flow rates, which may be relevant to the VTE pathways in cancer patients.
Topological equivalence between two classes of three-dimensional steady cavity flows: A numerical-experimental analysis
Authors: Contreras P. S. , Ataei-Dadavi I. , Speetjens M. F. M. , Kleijn C. R. , Tummers M. J. , Clercx H. J. H.
Published: December 2019

The present study concerns Lagrangian transport and (chaotic) advection in three-dimensional (3D) flows in cavities under steady and laminar conditions. The main goal is to investigate topological equivalences between flow classes driven by different forcing; streamline patterns and their response to nonlinear effects are examined. To this end, we consider two prototypical systems that are important in both natural and industrial applications: a buoyancy-driven flow (differentially heated configuration with two vertical isothermal walls) and a lid-driven flow governed by the Grashof (Gr) and the Reynolds (Re) numbers, respectively. Symmetries imply fundamental similarities between the streamline topologies of these flows. Moreover, nonlinearities induced by fluid inertia and buoyancy (increasing Gr) in the buoyancy-driven flow vs fluid inertia (increasing Re) and single- or double-wall motion in the lid-driven flow cause similar bifurcations of the Lagrangian flow topology. These analogies imply that Lagrangian transport is governed by universal mechanisms, and differences are restricted to the manner in which these phenomena are triggered. Experimental validation of key aspects of the Lagrangian dynamics is carried out by particle image velocimetry and 3D particle-tracking velocimetry.