bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi hubungan antara penguasaan kosakata dan minat menulis dengan keterampilan menulis deskripsi pada peserta didik kelas V sekolah dasar
Authors: Adityaningrum Dyah , Slamet St Y , Budiharto Tri
Published: March 2024

This study aims to 1) knowing whether there is a relationship between vocabulary mastery and description writing skills; 2) knowing there is a relationship between writing interest and description writing skills; 3) knowing whether there is a relationship between vocabulary mastery and writing interest together with descriptive writing skills. This research uses survey correlational study method. The population of this study were students of class V SD in Laweyan District, 2020/2021 academic year. Data collection techniques using tests and questionnaires. Based on the data analysis, it can be concluded that 1) there is a significant relationship between vocabulary mastery and the skill of writing descriptions of r count (0.72), the correlation coefficient was tested by t test, the results of tcount (10.36)> t table (1.66); 2) there is a significant relationship between writing interest and writing skills description r count (0.42), the correlation coefficient was tested by t test, the results of t count (4,63)> t table (1.66); 3) there is a significant relationship between vocabulary mastery and interest in writing along with descriptive writing skills ry12 of (0.85), the coefficient of significance with the F test is obtained Fcount = 136,47> Ftable = 3.09
Fenomena implementasi pembelajaran daring selama wabah covid-19 di SD Negeri Degan Kabupaten Pati
Authors: Larasati Niken , Kurniawan Sandra Bayu , Rintayati Peduk
Published: March 2024

This research aims to describe the meaning of online learning implementation during the Covid-19 pandemic at Degan State Elementary School, Pati regency. This research is a qualitative study using a phenomenological research design. The sampling technique used was the purposive sampling technique. The technique of collecting data used interview, observation, and documentation. The data validity test used technical triangulation. Data analysis is obtained from results of data collection using interactive analysis which includes data collection, data reduction, data presentation, and concluding. The results showed that implementation of online learning in Degan State Elementary School started with teacher preparation including making a porta, promissory note, syllabus, and lesson plan. The learning process was done through the WhatsApp group. The learning process started with greetings, motivation, perception, presenting material through learning videos, messages or voice messages, questions and answers, and submitting assignments. The assessment process is carried out using two methods, the first method is students sending their assignments by WhatsApp and the other method is students coming to school to directly collect assignments once a week. Obstacles in the implementation of online learning are network, internet quota, cellphone, and discipline.
Optimalisasi Slide Power Point dengan Penerapan Metode Diskusi Kelompok dalam Meningkatkan Hasil Belajar PKN Tentang Keutuhan Negara Republik Indonesia pada Peserta Didik Kelas V Sekolah Dasar
Authors: Sukarti Sukarti
Published: March 2024

The purposes of this research are describing the optimization of slide power point in
Group Discussion Method in Civic Education learning about the Unity of Indonesian Republic
on the five grade students of Bulu Elementary School on the First Semester 2016/2017
Academic Year and analyzing the optimization of slide power point in Group Discussion
Method toward to Civic Education learning result about the Unity of Indonesian Republic on
the five grade students of Bulu Elementary School on the First Semester 2016/2017 Academic
Year. This research is a Class Action Research (CAR). The subjects of this research are 16
students. The results of this research are 1) the optimization of slide power point in Group
Discussion Method is in a small group according to the sum and the characteristic of the
students, 2) the optimization of slide power point in Group Discussion Method has the
functions as the learning resource and learning media that showing relevant pictures with the
subject matter, 3) the application of Group Discussion Method in a small group is increasing
the students’ learning activities in discussion, answering the questions correctly and asking the
following questions, 4) the optimization of slide power point in Group Discussion Method has
the same of group composition, so the students are not adapting with their group, 5) the
optimization of slide power point in Group Discussion Method is increasing the students’
learning result, so qualified the minimal completeness criteria and minimal completeness at
75%.
Penerapan Metode Diskusi Kelompok Model Pembelajaran Jigsaw untuk Meningkatkan Hasil Belajar IPA dalam Materi Gerak Benda Siswa Kelas III Sekolah Dasar
Authors: Sumarti Sumarti
Published: March 2024

The purpose of this research is increasing the Third Grade students’ of 2
Pasarbanggi General Elementary School on Natural Science learning results about the Object
Movement through the application of group discussion method with Jigsaw learning model.
This research is a Class Action Research (CAR) that consists of 2 cycles and going on 2nd
Semester 2018/2019 Year Academic. The subjects of this research are 18 students. The
techniques of collecting data are test and non test. The technique of analyzing data is
descriptive. The result of this research is the increasing of the learning results. The learning
results on the Pre cycle are 60,9 for the average and 39% for the completeness. The learning
results on the First Cycle are 73,1 for the average and 72% for the completeness. The learning
results on the Second Cycle are 75,7 for the average and 94% for the completeness.
Peningkatan Keterampilan Guru dalam Mengajar Melalui Implementasi Supervisi Klinis
Authors: Timur Timur
Published: March 2024

The purpose of this research is increasing the teachers’ of 2 Kajar General
Elementary School, Sub District of Gunem, Regency of Rembang skills on teaching on 1st
Semester 2019/2020 Year Academic. The design of this research is a School Action Research
(SAR) with Kemmis and Mc Taggart model’s. The place of this research is 2 Kajar General
Elementary School, Sub District of Gunem, Regency of Rembang. The time of this research is
four months: from August up to November 2019. The subjects of this research are three
teachers; Teacher of IV Grade, V Grade and VI Grade. The object of this research is the
teachers’ skills on teaching. The techniqu of analyzing data of this research is descriptive
analyzing. The result of this research is the teachers’ of 2 Kajar General Elementary School,
Sub District of Gunem, Regency of Rembang skills on teaching on 1st Semester 2019/2020
Year Academic increased from poor category into good category.
Detection of Questions from Text Data Using LSTM-Deep Learning Model
Authors: Nadir Hussain  , Dr. Sheikh Muhammad Saqib  , Hamza Arif  , Muhammad Usman Gurmani
Published: March 2024

This paper discusses the importance of detecting questions in textual data for various applications in natural language processing (NLP), such as question answering and chatbot creation. The proposed approach employs long short-term memory (LSTM) models to accurately identify questions by leveraging the sequential nature of language.The paper highlights that LSTM models address challenges like ambiguous language and varying sentence structures. They allow the model to learn from sequential patterns, crucial for understanding the intent behind the text. The preprocessing steps, including tokenization, embedding, and padding, are detailed to prepare the data for training and testing. The study investigates the impact of hyperparameters like hidden layers, hidden states, and optimizer choice on the LSTM algorithm’s performance. In experiments on benchmark datasets, the proposed LSTM-based approach consistently outperforms conventional machine learning models, achieving a remarkable accuracy of 99.25% on the test dataset. The paper concludes by suggesting future directions, including applyingthe approach to other NLP tasks like named entity recognition, sentiment analysis, and text classification. Further optimization for specific datasets or domains is also encouraged. Overall, this research contributes to robust question detection models in NLP, with potential applications in various fields.
The Analysis of the Islamic Community Member Engagement Based on Instagram Content Types
Authors: Nasuka Moh , Wijaya Tony , Hidayat Anas , Muhamed Nurul Aini
Published: March 2024

This study aims to determine differences in the level of Islamic community member engagement based on Instagram content types, namely photos, videos, and carousels. The results of this research are expected to contribute to social media users, especially Instagram, in determining the most appropriate types of content posts. This study is an ex post facto and uses secondary data from all posts of the most popular smartphone application-based Islamic community accounts in Indonesia, resulting in a total of 18,026 posts. Engagement rate is measured based on the number of likes and comments. Data is collected by documenting secondary data on Instagram. The sampling technique used was purposive sampling with the criteria of prioritizing new posts over old ones, considering that new posts tend to have a higher engagement; thus, the data will be more easily observed. The data analysis technique used is ANOVA. The findings demonstrated that there were notable distinctions in the number of likes and comments between photo posts and video posts, that photo posts had a higher degree of engagement than video posts, and that there were notable distinctions in the number of likes and comments between photo posts and carousel posts. Regarding likes and comments, photo posts receive more than carousel posts, and there is no difference between carousel posts and video posts; carousel posts and video posts receive the same amount of engagement. Based on the findings, it can be suggested that Islamic community managers pay attention to the choice of content type when uploading a post to an Instagram account to get optimal engagement. In addition, posting a single image often elicits more attention or engagement compared to video posts and carousels as well.
The Efficiency of Islamic Banks in the Middle East and Southeast Asia: Stochastic Frontier Approach
Authors: Adawiyah Robi'atul , Suhel Suhel , Syathiri Ahmad
Published: March 2024

This research aims to compare and analyze the efficiency of Islamic banking in Southeast Asia and the Middle East by examining particular inputs such as third-party funds, operational expenses, labor costs, and return on assets, focusing on financing as the output. This quantitative study uses a purposive sampling technique to sample 30 sharia banks from Southeast Asia and 30 sharia banks from the Middle East from 2015 to 2022. The data used is secondary data from BankFocus and the annual financial reports of each bank. Data was processed using the Frontier 4.1 application with the Stochastic Frontier Analysis method. The results of this research show that the efficiency of sharia banking in the Middle East is higher than sharia banking in Southeast Asia. On the other hand, the return on assets has no impact on financing, but the input of third-party funds, operational expenses, and labor costs all have an impact. These findings show the importance of efficiently supervising the management of third-party funds and costs incurred by banks in order to improve banking performance. Hence, this will ultimately lead to an increase in the efficiency of sharia banking and a growth of banking profits.
Panel Data Regression on Tax Avoidance: Reviewed from Islamic Corporate Social Responsibility and Financial Ratio Analysis
Authors: Restuti Dwi Putri , Cahya Bayu Tri , Amaroh Siti
Published: March 2024

Tax avoidance becomes unique because it is allowed in the sense that it does not violate the law. However, it is undesirable in practice because it affects the country’s revenue. This study experimentally investigates the relationship between Islamic corporate social responsibility, profitability, leverage, inventory intensity, capital intensity, and tax avoidance. This research employs a causal methodology and is quantitative. Only businesses listed on the Indonesian Islamic Stock Index (ISSI) were included in this analysis. The purposive sampling approach was employed to gather a sample of 15 companies for the 2016–2021 research period. Profitability has a negative impact on tax avoidance, leverage has a negative impact on tax avoidance, inventory intensity has a positive and significant impact on tax avoidance, capital intensity has no discernible impact on tax avoidance, and Islamic corporate social responsibility has no discernible impact on tax avoidance.
Tube Blockage Solutions for Industrial Heat Exchangers
Authors: Ferdiansyah Faris , Firdaus Rachmat
Published: March 2024

This study investigates the root causes of blockages in heat exchanger tubes and proposes effective mitigation strategies. Industrial heat exchangers face recurrent challenges from tube blockages, impairing operational efficiency. Through a combination of experimental analysis, computational modeling, and data-driven approaches, the research identifies the role of contaminants in causing pressure drops and outlines targeted maintenance protocols. Findings underscore the significance of proactive measures in optimizing heat exchange processes, offering valuable insights for enhancing system performance across diverse industrial applications.
Highlights:

Tube blockages disrupt production efficiency.
Pressure drop due to blockages affects system performance.
Analysis needed for prevention measures.

Keywords: Production Process, Blockage, Exchangere
STUDENTS’ WRITING ABILITY IN ONLINE ENGLISH LEARNING OF TWELFTH GRADE OF MIPA 2 OF SMA NEGERI TULAKAN IN THE ACADEMIC YEAR 2020/2021
Authors: Pinaningsih Pinaningsih , Kurniawan Agung Budi , Hafidah Agustina Sri
Published: March 2024

The objectives of the research are to find students’ writing ability in online English learning. Themethod used in the research was a case study. The researcher used the quantitative. The data weregathered from this study through tests. The subjects of this research were students of XII MIPA 2 atSMA Negeri Tulakan, who were 20 students. This research finding showed that the mean score ofstudents’ writing ability is 70.85. Then the median of students’ writing score is 66. The modus ofstudents’ writing ability is 57 and 64.The standard deviation in SMA Negeri Tulakan is 75. From thefinding and data analysis, itcan be concluded that 12 from 20 students get the score of writing understandard deviation. Then eight from twenty students get the score up to standard deviation. Most ofthem have difficulties determining ideas or content, organization or coherence text, arranginglanguage use or grammar, word choice or vocabulary, and mechanics errors, including punctuation,capitalization, and spelling. There are some data or facts about students’ ability to construct theirs.Based on the English teacher interview’s result, teaching English online learning is not going well.Both the teachers and students must be able to adapt to online learning. Another obstacle of onlinelearning is some students don’t have a cellphone that supports the online learning media. Manystudents had difficulties, such as internet network constraints and limited quotas of internet data.Students are also less interactive in English online learning.
THE FILTERS AND BARRIERS OF ENGLISH CLASSROOM LEARNING OF HIGH SCHOOL STUDENTS IN SOUTHERN BANGKA INDONESIA
Authors: Haiyudi Haiyudi
Published: March 2024

This research aims to identify the filtering or barriers experienced by students learning English. Mixed-method research using a case study approach with embedded type is employed in designing this study. An integrated questionnaire and interview entitled Filtering Experiences by High School Students were distributed in gaining the data. While the sample of this study was 50 students from two different high schools in Pongok Island, Southern Bangka, Indonesia. The findings of this study indicate that the average value obtained is 3.85 on a given scale of 5. It Indicates that most students do not have filtering in learning English in the classroom. From the interview, it was found that the students were fully aware that English is essential to learn. However, it was also found that the external factor that affected the low motivation of learning was the attitudes and ways of teaching by English teachers
PROBLEMS FACE BY VOCATIONAL HIGH SCHOOL STUDENTS IN LEARNING ENGLISH AT SMK NEGERI KEBONAGUNG
Authors: Hadi Samsul , Intan Permatasari Oktavia , Nurma Yuniar Siska , Wannisa Widha
Published: March 2024

Learning English is very important especially for education and future, this is because English is one of the international languages ​​used. This case study aims to analyze the difficulties of learning English in grade 10 students at the vocational high school level. This research is mainly to find the students' difficulties in mastering English. This research was conducted at SMK Negeri Kebonagung involving 70 students as subjects. Researchers used a classical and individual approach in collecting data. The data was obtained using a google form which was distributed to 70 students of class x in various majors. The findings show that students' English learning difficulties are: (1) a sense of coercion; (2) mastery of basic concepts/low intake; (3) lack of self-confidence; (4) forgetting factor; (5) have little opportunity to practice. Referring to these findings, it is suggested to teachers and institutions to facilitate and provide high motivation for the students' English learning process.
APPLICATION OF AUTHENTIC ASSESSMENT METHODS FOR STUDENTS' WRITING SKILL
Authors: Khamasah Fikaoniki , Atibrata Tyas
Published: March 2024

This research was conducted to determine the application of authentic assessment in the writing skills of students of class X MA Assalafiyyah Mlangi Sleman Yogyakarta. The scope of this research is divided into several points, namely: (1) what authentic assessment is applied by the teacher, (2) what obstacles in applying authentic assessment in English writing skills. The researcher used a qualitative descriptive method. Data collection techniques used are interviews, observation, and documentation. The researcher analyzed the data using analysis from Miles and Huberman which includes data reduction, data presentation and conclusions and verification. The results of the study, namely: the teacher applies an authentic assessment of students' writing skills through three aspects, affective aspects, cognitive aspects, and skills aspects. On the affective aspect: the teacher uses the technique of observation, self-assessment, peer-assessment and journals. The teacher prioritizes journal techniques in English writing skills. Cognitive aspects: written tests and assignments, both of these techniques are applied in class in writing skills lessons. Skills aspect: product assessment and portfolio assessment, teachers do not apply project assessment because they focus on other techniques. Overall, teachers know the application of authentic assessment to writing skills based on the 2013 curriculum, even though they apply authentic assessment to learning activities, such as: having limited time, limited knowledge of students in English.
INDONESIAN STUDENTS’ PERSPECTIVES ON ELT IN SHADOW EDUCATION
Authors: Aini S Qurrotul , Putra Kristian Adi
Published: March 2024

The demand for shadow education in Indonesia is continuously increasing, raising the doubts on the quality of teaching at schools. Therefore, this study aims at analyzing students’ perceptions particularly on English language teaching in shadow education, as compared to those at schools. This study uses semi-structured individual interviews to obtain rich data on students’ experiences and perceptions. The participants were secondary level students who were well-experienced in English shadow education program. The result of this study showed that students’ perception of shadow teaching covered several aspects such as teaching materials, learning outcome, teaching activities, teachers’ teaching performance and learning media. Practically, the students’ perspective towards shadow education had an average of positive experiences. Furthermore, the implications of  present study call for a sense of urgency among policy makers and education authorities to consider curricular and methodological overhauling to enhance English teaching efficiency and students’ learning outcomes in line with students’ needs, preferences and concerns in shadow teaching.
Bias Gender on Language Learning
Authors: Lutfi Mutohar , Supriyanto Adinda Cahayani , Abdallah Putra Aqiel Sifa` , Rakhmawati Fitri
Published: March 2024

The diversity in the process of learning language is wonderful, especially the diversity between males and female student on their understanding in learning English as foreign language which is relate to their language learning competence. In this case the language learning abilities are biased by gender which affected their learning output. Hypothetically, there must be relations between the gender identity and learning ability toward English learning output. To verify the hypothesis, the authors begin with the formulation of collective data collection that collected from the student`s English written text products from the secondary school which targeted high school students, then the data will be analyzed with systemic functional linguistics and feminist stylistics approach to understand the gender bias on the texts construction and to investigating the structural choice of language. The data analysis also elaborates with language learning theory to support the evidence and to verify the hypothesis. This research is designed for the development of language learning especially in English as foreign language. The development is addressed the future researchers and language teachers to develop the theory and to arrange the language learning strategies for better future of language education.
STUDENTS’ ACADEMIC DISHONESTY IN EXAMINATION PROCESS
Authors: Nurjanah Mifta , Elmiati, M.Pd  , Rani Autila, M.Pd
Published: March 2024

This research was conducted to desribe student’s academic dishonesty in examination process. The researcher used a Sequential Explanatory mixed method, a method that combines both quantitative and qualitative methods with descriptive research. Techniques in data collection is questionnaire and interview. The result showed that the popular forms of academic dishonesty among the students were cheating on their friend without his or her knowledge, carrying crib notes, allow their friend to copy answer sheet, collaborate with friends and etcetera. Based on the results of the study it can be concluded that students’ do academic dishonesty in examination process.
Optimization Strategies of Sustainable Urban Land Use Planning Using a Hybridized Technique Based on SWOT-AHP, and GIS in Ibb City, Yemen
Authors: Dammag Abdulkarem Qasem , Jian Dai , Dammag Basema Qasim Derhem
Published: March 2024

The high rate of population growth led to migration from rural to urban settlements, causing unregulated growth, urban sprawls, and inefficiencies in city planning of developing countries. yet, in regions like Yemen, rapid urbanization poses significant challenges for urban planners. Addressing these challenges, this study proposes an innovative approach to urban planning in the context of Ibb City, Yemen, a region grappling with rapid urbanization and inefficient land use. The study identifies a significant gap in the integration of strategic planning and technological tools in developing urban areas. The study utilized SWOT technology to examine the internal and external factors, the AHP method to prioritize the factors to make them measurable, and GIS geospatial zonal analysis. This integrated approach provides a comprehensive evaluation of internal and external factors affecting urban land use, with a focus on quantifying priorities for sustainable urban development. The study's results offer a detailed assessment of the social, economic, infrastructure, and environmental aspects of Ibb City, highlighting the interaction between these elements in urban planning. Importantly, the findings extend beyond the local context, presenting a scalable and adaptable model for urban planning, particularly in developing countries with similar urban dynamics. The study underscores the critical role of strategic, data-driven planning in fostering sustainable urban environments, offering significant insights and tools for policymakers and urban planners for sustainable urban growth.
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer
Authors: Shepherd Trevor , Buensuceso Adrian , Borrelli Matthew , Valdes Yudith Ramos
Published: March 2024

Upon detachment from the primary tumour, epithelial ovarian cancer cells can form multicellular aggregates, also referred to as spheroids, that have the capacity to establish metastases at distant sites. These structures exhibit numerous adaptations that may facilitate metastatic transit and promote tumorigenic potential. One such adaptation is the acquisition of dormancy, characterized by decreased proliferation and molecular features of quiescence. One of the most frequently dysregulated genes in cancer is MYC, which encodes a transcription factor that promotes cell proliferation. In this study, we demonstrate that MYC protein abundance and associated gene expression is significantly decreased in EOC spheroids compared to adherent cells. This downregulation occurs rapidly upon cell detachment and is proteasome-dependent. Moreover, MYC protein abundance and associated gene expression is restored upon spheroid reattachment to an adherent culture surface. Overall, our findings suggest that suppression of MYC activity is a common feature of EOC spheroids and may contribute to the reversible acquisition of dormancy.
Outcome of induction and associated factors among induced laboring mother at Dessie Comprehensive specialized Hospital, Dessie, Ethiopia.
Authors: LIMENIH ABEL SHIFERAW , KIDANEMARIAM AKEBOM , DURESSA ABDI DINGETA
Published: March 2024

Background
Induction of labor refers to iatrogenic stimulation of uterine contractions before the onset of spontaneous labor to accomplish vaginal delivery. It is a common obstetric procedure performed during pregnancy and is thought to be associated with greater maternal or fetal risk. Although the induction of labor is commonly practiced, its outcomes and associated factors are rarely assessed in our settings. Therefore, this study aimed to fill this gap by studying the outcomes of labor induction and associated factors among women who delivered at the Dessie Compressive Specialized Hospital.
Objective
The objective of this study was to assess the outcome induction of labor and associated factors among induced laboring mothers at the Dessie Compressive Specialized Hospital from March 1, 2023 to June 30, 2023.
Methods
An institution-based cross-sectional study was conducted on 308 study participants from March 1, 2023 to June 30, 2023. Data were collected through daily patient interviews and chart reviews of the individual mothers for additional information. Study participants were recruited using a consecutive sampling method. Data were entered using Epi-Data Version 4.6 and analyzed using SPSS Version 25. A bivariate logistic regression model was used to identify factors affecting the outcome of labor induction. Variables with P-values less than 0.25 in the bivariate analysis were entered into the multivariate analysis. Odds ratios (ORs) with 95% confidence intervals (CI) were used to assess association strength. Statistical significance was set at P < 0.05.
Results
The results of the study revealed that, out of 308 total cases of labor induction, 232(75.32%; 95% CI = 70–80) of them achieved successful labor induction. A favorable Bishop Score (AOR = 16.46, 95% CI = 7.685–35.283), multigravida (AOR = 5.17, 95% CI = 2.293–11.657), rural resident (AOR = 3.0393, 95% CI = 1.270–7.5730), and ripening by misoprostol (AOR = 5.203, 95% CI = 1.834–14.763) were significantly associated with successful labor induction.
Conclusion
The proportion of successful induction of labor was moderate in the study area. Favorable Bishop Score, Multigravida, ripening by misoprostol, and rural residency are the main determinants. It may be necessary to conduct case-control or cohort studies to further investigate factors that increase the likelihood of failed induction.
Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function.
Authors: Gasser Edith Schneider , Schaer Ron , Mueller Flavia , Bernhardt Alexandra , Lin Han-Yu , Arias-Reyes Christian , Weber-Stadlbauer Ulrike
Published: March 2024

Prenatal exposure to infections is a risk factor for neurodevelopmental disorders in offspring, and alterations in mitochondrial function are discussed as a potential underlying factor. Here, using a mouse model of viral-like maternal immune activation based on poly(I:C) (POL) treatment at gestational day (GD) 12, we show that adult offspring exhibit behavioral deficits, such as reduced levels of social interaction. In addition, we found increased NADH- and succinate-linked mitochondrial respiration and maximal electron transfer capacity in the prefrontal cortex (PFC) and in the amygdala (AMY) of males and females. The increase in respiratory capacity resulted from an increase in mitochondrial mass in neurons (as measured by complex IV activity and transcript expression), presumably to compensate for a reduction in mitochondrion-specific respiration. Moreover, in the PFC of control (CON) male offspring a higher excess capacity compared to females was observed, which was significantly reduced in the POL-exposed male offspring, and, along with a higher leak respiration, resulted in a lower mitochondrial coupling efficiency. Transcript expression of the uncoupling proteins (UCP4 and UCP5) showed a reduction in the PFC of POL male mice, suggesting mitochondrial dysfunction. In addition, in the PFC of CON females, a higher expression of the antioxidant enzyme superoxide dismutase (SOD1) was observed, suggesting a higher antioxidant capacity as compared to males. Finally, transcripts analysis of genes involved in mitochondrial biogenesis and dynamics showed reduced expression of fission/fusion transcripts in PFC of POL offspring of both sexes. In conclusion, we show that MIA causes alterations in neuronal mitochondrial function and mass in the PFC and AMY of adult offspring with some effects differing between males and females.
Optimization scheduling of microgrid comprehensive demand response load considering user satisfaction
Authors: Wang Chaoliang , Li Xiong
Published: March 2024

Flexible load control of microgrid based on demand-side management not only improves energy efficiency of the supply side of microgrid, but also considers the overall willingness to users. Regarding the limitations of the current microgrid demand response model, this paper further optimizes the flexible load control strategy and proposes a two-objective optimization model based on price and incentive. Meanwhile, the model is solved using an improved chaotic particle group algorithm. Finally, the microgrid load data were selected for simulation analysis. The simulation results showed that the comprehensive demand response of flexible control model proposed increased the overall satisfaction of users by 9.51%, the overall operating cost of microgrid suppliers decreased by 12.9752/ ten thousand yuan, the peak valley difference decreased by 4.61%, and the user demand response increased by 27.24%. The model effectively improves the overall profit of the supply side of the microgrid, improves the user satisfaction, and maximizes the linkage benefits of the supply and demand of the micro grid.
Evaluation of Water Ecological Security of Mountain City Based on the Frame of “Water-Soil, Water-City, and Water-Net”
Authors: Liu Yali , Lu Tao , Liu Fang , Zhang Zhen , Yan Jingjing , Wu Fangfang
Published: March 2024

By using the concept of Territorial Spatial Planning, this paper constructed the framework of water ecological security evaluation of territorial space in mountain cities, based on the perspectives of Macro-, Medium- and Micro-, and the 3 levels of “Water-soil, Water-city, Water-net”. Establish the method of water ecological security evaluation of territorial space in mountainous city with “3 levels, 4 characteristics, 6 dimensions and 12 actions”, by combining the 3 basic disciplines of “ecology, environment and security”, focusing on the 3 core functions of ”water-soil conservation, water-city integration, water-net linkage”, to the target of the 4 requirements of “ecological civilization, environmental friendliness, security and resilience, mountain application”, concentrating on the 6 spatial dimensions of “Source- Shelter -City-Shore-Net-Flow”, revolving around the 12 major water actions “Water conservation, Water maintenance, Water protection, Water restoration; Water identification, Water management, Water Connectivity, Water control; Water mediation, Water guidance, Water cycle, Water treatment”. Through an empirical study in typical mountain city, fill up the blank of Territorial Spatial Water Ecological Security Evaluation of mountain city, and provide basic method guidance and key technical support for the integrated development of mountain city with high quality.
Differential Association of Abdominal, Liver and Epicardial Adiposity with Anthropometry and Cardiac Remodeling in Asians
Authors: Chin Calvin , Lee Vivian , Han Yiying , Toh Desiree-Faye , Bryant Jennifer , Boubertakh Redha , Le Thu-Thao
Published: March 2024

Background
Heterogenous deposition and homeostasis roles of physiologic and ectopic adipose tissues underscore the implication of fat compartmentalization on cardiometabolic risk. We aimed to characterize the distribution of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial adipose tissue (EAT) and liver fat on magnetic resonance imaging (MRI), and evaluate their associations with anthropometric indices and adverse cardiac remodeling.
Methods
In this cross-sectional observational study, all 149 Asian adults (57.0±12.8 years; 65% males) with at least one cardiometabolic risk factor underwent fat and cardiovascular MRI. Anthropometric indices included body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and bioimpedance body fat mass (BFM).
Results
We observed opposing associations of VAT and SAT with liver fat and EAT, therefore VAT/SAT ratio was explored as an integrated marker of visceral adiposity. VAT/SAT was associated with EAT (β=0.35, P<0.001) and liver fat (β=0.32, P=0.002) independent of confounders. Of the anthropometric measures assessed, only WHR was independently associated with VAT/SAT (β=0.16, P=0.03). Individuals with T2DM had higher VAT and lower SAT compared to those without T2DM, translating to a significantly higher VAT/SAT ratio. Independent association was observed between greater EAT volume and adverse features of cardiac remodeling: increased left ventricular mass (β=0.24, P=0.005), larger myocyte volume (β=0.25, P=0.002), increased myocardial fibrosis (β=0.19, P=0.032), higher concentricity (β=0.18, P=0.035) and elevated wall stress (β=−0.18, P=0.023).
Conclusions
VAT/SAT ratio is a promising marker for multiorgan visceral fat composition T2DM. EAT is uniquely associated with adverse cardiac remodeling, suggesting distinctive cardiometabolic properties from other fat depots.
TPMS-based auxetic structure for high-performance airless tires with variable stiffness depending on deformation
Authors: Kim Do-Yeon , Kim Hong-Seok , Kamath Sarath , Hou Xiangying , Choi Jae-Won , Park Sang-Hu
Published: March 2024

A novel auxetic structure applicable to airless tire spokes is designed based on the primitive-type triply periodic minimal surface (P-TPMS) to have higher stiffness through deformation under compressive force. For becoming higher stiffness by deformation, an unit cell of auxetic structure is proposed and its characteristics according to design parameters are studied. Based on the parametric study, a rotated primitive-type auxetic structure (RPAS) is designed, and the deformative behaviors of an airless tire with the RPAS spokes are compared with a generally used honeycomb spoke. Simulation and experiment results show that the designed RPAS tire exhibits more stable behavior through higher rigidity depending on the deformation state when compressed on flat ground and obstacles. This variable stiffness characteristic of RPAS tires can be advantageous for shock absorption and prevention of large local deformations. Also, the manufacturability of the designed auxetic structure is evaluated using real rubber-based additive manufacturing processes for practical application in the tire manufacturing industry.
Effect of the COVID-19 on Patients with Systemic Lupus Erythematosus during the First Pandemic Wave in China
Authors: Wu Pengjia , Liu Xiaoxia , Li Na , Fan Youyang , Liu Jun , Qin Longyan , Yang Lei , Zhang Aifei , Zeng Jiashun
Published: March 2024

Objective: This study aimed to investigate the prevalence and clinical manifestations of coronavirus disease (COVID-19) in patients with systemic lupus erythematosus (SLE) during the first wave of the pandemic in China and to evaluate the effects of COVID-19 on the disease activity and treatment of SLE.
Methods: A telephone survey was conducted on patients diagnosed with SLE in our hospital between October 2017 and October 2022. Through the survey, we investigated whether the patients had COVID-19, the clinical manifestations of the infection, whether the patients were vaccinated, the effects of the infection on the disease activity of SLE, and whether the treatment regimen for SLE was adjusted due to the infection.
Results: A total of 351 patients participated in this study, of whom 261 (74.4%) had COVID-19. Regarding organ involvement, the circulatory system was more commonly affected than the other organs in patients with SLE without COVID-19 (P = 0.002). Regarding concomitant medications, the daily dose of glucocorticoids was higher than that of other medication in SLE patients without COVID-19 (P = 0.000). No differences were observed in age, disease duration, disease activity, of other concomitant medications. While infected with COVID-19, 46 patients (17.6%) discontinued parts of their treatment without experiencing any episodes of SLE.
Conclusion: Most SLE patients with COVID-19 had a good prognosis, and all the patients in our study recovered from COVID-19 infection. Abrupt dose reduction and discontinuation of medications by the patients themselves may lead to elevated disease activity or even episodes of SLE. As such, it is recommended that the patients adjust their treatment regimens following the guidance of their specialists after careful evaluation of their condition and SLE disease activity by specialists.
RETRACTED: Genesis of sulfide hosted invisible gold mineralization within the Vempalle dolostone of Korivipalle area, Cuddapah Supergroup, southern India.
Authors: Behera Ramesh Chandra , Singh Sahendra , Srivast Shalivahan , Barla Anmol , Dash Mahimaa
Published: March 2024

The authors have requested that this preprint be removed from Research Square.
Identification and verification of immune-related genes for diagnosing the progression of atherosclerosis and metabolic syndrome
Authors: Xie Qian , Zhang Xuehe , Liu Fen , Luo Junyi , Liu Chang , Zhang Zhiyang , Yang Yining , Li Xiaomei
Published: March 2024

Background
Atherosclerosis and metabolic syndrome are the main causes of cardiovascular events, but their underlying mechanisms are not clear. In this study, we focused on identifying genes associated with diagnostic biomarkers and effective therapeutic targets associated with these two diseases.
Methods
Transcriptional data sets of atherosclerosis and metabolic syndrome were obtained from GEO database. The differentially expressed genes were analyzed by RSTUDIO software, and the function-rich and protein-protein interactions of the common differentially expressed genes were analyzed.
Results
A total of 1242 differential genes (778 up-regulated genes and 464 down-regulated genes) were screened from GSE28829 data set. A total of 1021 differential genes (492 up-regulated genes and 529 down-regulated genes) were screened from the data set GSE98895.Then 23 up-regulated genes and 11 down-regulated genes were screened by VENN diagram.Functional enrichment analysis showed that cytokines and immune activation were involved in the occurrence and development of these two diseases.Through the construction of PPI network and Cytoscape software analysis, we finally screened 10 HUB genes.The immune infiltration analysis was further improved. The results showed that the infiltration scores of 7 kinds of immune cells in GSE28829 were significantly different among groups (Wilcoxon Test < 0.05), while in GSE98895, the infiltration scores of 4 kinds of immune cells were significantly different between groups (Wilcoxon Test < 0.05).Spearman method was used to analyze the correlation between the expression of 10 key genes and 22 kinds of immune cell infiltration scores in two data sets.The results showed that there were 42 pairs of significant correlations between 10 genes and 22 kinds of immune cells in GSE28829 (| Cor | > 0.3 & P < 0.05).There were 41 pairs of significant correlations between 10 genes and 22 kinds of immune cells in GSE98895 (| Cor | > 0.3 & P < 0.05).Finally, our results identified 10 small molecules with the highest absolute enrichment value, and the three most significant key genes (CX3CR1, TLR5, IL32) were further verified in the data expression matrix and clinical blood samples.
Conclusion
We have established a co-expression network between atherosclerotic progression and metabolic syndrome, and identified key genes between the two diseases. this may be helpful to provide new research ideas for the diagnosis and treatment of atherosclerosis complicated with metabolic syndrome.
Alcohol use disorder among people diagnosed with Tuberculosis in a large urban case-finding project in central Uganda: prevalence, associated factors and challenges to treatment adherence
Authors: Bayigga Josephine , Kakai Ilona , Laker Eva , Ddungu Ahmed , Semakula Lynn , Nansereko Martha , Wiltshire Christine Sekaggya , Stavia Turyahabwe , Muyanja Stella
Published: March 2024

Background
Heavy consumption of alcohol increases the risk of developing active tuberculosis (TB), contributes to delayed diagnosis and affects adherence to treatment. Within a large urban case-finding project, we aimed to determine the prevalence of and factors associated with alcohol use disorder (AUD) and to understand the challenges that people with AUD face while seeking for TB services and adhering to TB treatment.
Methods
We carried out an explanatory sequential study in two large urban districts in Uganda. We collected quantitative data on the prevalence of alcohol use disorder using the Cut, Annoyed, Guilty, Eye opener (CAGE) tool. We used a Poisson regression model with robust variance to examine factors associated with AUD. Both the crude and adjusted prevalence risk ratios with 95% confidence intervals were presented. We then conducted two focus group discussions with persons diagnosed with both TB and AUD. Focus group discussions (FGDs) were transcribed, data were analysed inductively and coded into themes using NVIVO version 12 software.
Results
Out of 325 people with TB people interviewed, 62 (18.7% 95% confidence interval [CI] 18% to 31%) had AUD. Majority 82.3% (51/62) were men. Being male aPR 2.32 (95% CI 1.19, 4.49) and living in an urban area aOR 1.79 (95% CI: 1.10, 2.92) were significantly associated with AUD. Among people with AUD, there was a tendency towards suboptimal TB treatment outcomes, although this did not reach significance aPR 1.65 (95% CI: 0.95, 2.85). Fourteen people (eight men and six women) with diagnosed with AUD attended two FGDs. People with AUD often did not disclose alcohol use during TB treatment and missed clinic refill appointments due to lack of transport fares to the clinic.
Conclusion
A significant proportion of people with TB have undisclosed AUD and experience several challenges while on TB treatment. TB care programs need to design interventions that actively assess for AUD and in order to address related challenges.
Genetic variation associated with increased lambda-cyhalothrin resistance in Spodoptera frugiperda (Lepidoptera: Noctuidae) in West Africa
Authors: Tossou Eric , Tepa-Yotto Ghislain T. , Goergen Georg , Tchigossou Genevieve M. , Tchouakui Magellan , Nguete Daniel Nguiffo , Amadou Laouali , Noussourou Moussa , Bokonon-Ganta Aimé H. , Wondji Charles , Tamò Manuele , Djouaka Rousseau
Published: March 2024

The fall armyworm Spodoptera frugiperda (J.E. Smith) is a new serious destructive and widespread pest of corn which recently invaded subtropical regions worldwide. As this invasive species is spreading across the continent, it is vital to assess its susceptibility to currently used insecticides and establish the potential underlying resistance mechanism to better inform control programmes. In this study, we characterized the strains from eighteen fall armyworm populations from different countries in West Africa, established their susceptibility profiles to the main insecticides and genotyped the target site resistance alleles. The RFLP-PCR method showed that the majority of the population tested was a corn strain (72.5 – 100%) compared to the probable rice strain (0 – 27.5%). Tpi sequencing of the suspected rice strains revealed that almost all the samples analysed were from corn (>97%). Additionally, among the three insecticides tested, λ-cyhalothrin and chlorpyrifos induced the lowest toxicity against this pest, while emamectin benzoate exhibited moderate toxicity. Synergism tests performed to investigate the biochemical mechanism used by fall armyworm to breakdown λ-cyhalothrin indicated that metabolic enzymes (oxydases, esterase and the glutathion-S-transferase) play major roles in the resistance of λ-cyhalothrin observed in western Africa. Target mutation tests (qPCR) combined with previous synergetic tests showed that resistance to organophosphates and pyrethroids could be due to a biochemical mechanism + amino acid mutations (presence of the F290V mutation) or a biochemical mechanism (absence of the T929I mutation), respectively. The results of this study provide valuable information for supporting decisions related to sustainable fall armyworm control and applied resistance management.