bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymptotic properties of the estimator of the conditional distribution for associated functional data
Authors: Hamri Mohamed Mehdi , Dib Abdassamad , Rabhi Abbes
Published: November 2022

The purpose of the paper was to investigate by the kernel method a nonparametric estimate of the conditional density function of a scalar response variable given a random variable taking values in a separable real Hilbert space when the observations are quasi-associated dependent. Under some general conditions, the authors established the pointwise almost complete consistencies with rates of this estimator. The principal aim is the investigate the convergence rate of the proposed estimator.
Kobiety głoszące Ewangelię w Nowym Testamencie
Authors: Kubiś Adam
Published: November 2022

Artykuł prezentuje charakteryzację kobiet, które w Nowym Testamencie określone są explicite lub implicite jako głosicielki Ewangelii: (1) Maria Magdalena i inne kobiety przy grobie Jezusa; (2) kobieta samarytańska w J 4, 4–42; (3) Pryska/Pryscylla; (4) Ewodia i Syntyche z Flp 4, 2–3. Artykuł zwraca uwagę na historyczny i teologiczny kontekst ich działalności oraz definiuje treść i przedmiot ich  głoszenia, czyli Ewangelię. W prezentacji każdej z kobiet lub grupy kobiet wskazano na najważniejsze problemy egzegetyczne i współczesne próby ich rozwiązania.
Równość kobiety i mężczyzny w godności i prawie do sakramentów ze szczególnym uwzględnieniem święceń i małżeństwa
Authors: Trojanowski Bartosz
Published: November 2022

Fundamentalne prawo wiernych do sakramentu pochodzi z ustanowienia Bożego. Jest ono gwarantem możliwości osiągnięcia duchowych dóbr, które są niezbędne do zbawienia. Jedynie prawo Boże zawarte w istocie samych sakramentów może to prawo ograniczyć. Wśród fundamentalnych warunków, które trzeba spełnić, aby można było korzystać z prawa do sakramentu są te, które zostały wymienione w kan. 843 Kodeksu prawa kanoniczngo. Prawodawca powszechny troszczy się o równe traktowanie wszystkich wiernych ze względu na ich godność. Z niej wypływa równouprawnienie kobiety i mężczyzny również w kwestii przystępowania do  sakramentów. Dotyczy to wszystkich siedmiu sakramentów. W przypadku chrztu, bierzmowania, Eucharystii, pokuty i pojednania oraz namaszczenia chorych prawodawca nie wprowadza żadnych różnic co do płci ani nawet o niej nie wspomina. Największe dyskusje w sprawie równouprawnienia budzi możliwość przystępowania do sakramentu święceń tylko mężczyzn. Jednakże należy stwierdzić, że Kościół jest wolny w wyborze kandydatów do święceń. Dlatego należy stwierdzić, że również mężczyźni nie mają takiego prawa. Z tego względu mężczyźni i kobiety są również równi w prawie w tej kwestii. W przypadku sakramentu małżeństwa, kobieta i mężczyzna są zrównani w prawie i obowiązkach (por. KPK, kan. 1055). Można byłoby stwierdzić, że kobieta w pewnym sensie jest uprzywilejowana w Kościele łacińskim, jeśli chodzi o przeszkodę uprowadzenia. Jednak w intencji prawodawcy jest zapewnienie wszystkim prawa do wolnego wyboru małżonka. Dlatego wszystkie decyzje normatywne, zarówno kanoniczne, jak i liturgiczne, mają na celu uwydatnienie tej równości kobiety i mężczyzny.
Aktualność charyzmatu franciszkańskiego w przepowiadaniu papieża Franciszka
Authors: Włodarczyk Egidiusz Jarosław
Published: November 2022

Artykuł stawia sobie za cel ukazanie aktualności charyzmatu franciszkańskiego w nauczaniu papieża Franciszka. Zarówno duchowość franciszkańska, jak i nauczanie papieża Bergoglio stanowią zagadnienia bardzo obszerne. Wskazanie wszystkich punktów wspólnych wymagałoby o wiele obszerniejszego opracowania. W tekście dokonano zestawienia najistotniejszych faktów i wypowiedzi papieża, które potwierdzają jego fascynację osobą św. Franciszka z Asyżu. Fakt, iż papież, żyjący 800 lat od czasów posługi św. Franciszka, obiera go jako patrona, wielokrotnie przywołuje jego osobę i słowa, ukazując je jako cenną wskazówkę dla współczesnego człowieka, świadczy o niezmiennej aktualności charyzmatu franciszkańskiego.
Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants
Authors: Pais Pedro , Galocha Mónica , Takahashi-Nakaguchi Azusa , Chibana Hiroji , Teixeira Miguel C.
Published: November 2022

The emergence of drug resistance significantly hampers the treatment of human infections, including those caused by fungal pathogens such as Candida species. Candida glabrata ranks as the second most common cause of candidiasis worldwide, supported by rapid acquisition of resistance to azole and echinocandin antifungals frequently prompted by single nucleotide polymorphisms (SNPs) in resistance associated genes, such as PDR1 (azole resistance) or FKS1/2 (echinocandin resistance). To determine the frequency of polymorphisms and genome rearrangements as the possible genetic basis of C. glabrata drug resistance, we assessed genomic variation across 94 globally distributed isolates with distinct resistance phenotypes, whose sequence is deposited in GenBank. The genomes of three additional clinical isolates were sequenced, in this study, including two azole resistant strains that did not display Gain-Of-Function (GOF) mutations in the transcription factor encoding gene PDR1. Genomic variations in susceptible isolates were used to screen out variants arising from genome diversity and to identify variants exclusive to resistant isolates. More than half of the azole or echinocandin resistant isolates do not possess exclusive polymorphisms in PDR1 or FKS1/2, respectively, providing evidence of alternative genetic basis of antifungal resistance. We also identified copy number variations consistently affecting a subset of chromosomes. Overall, our analysis of the genomic and phenotypic variation across isolates allowed to pinpoint, in a genome-wide scale, genetic changes enriched specifically in antifungal resistant strains, which provides a first step to identify additional determinants of antifungal resistance. Specifically, regarding the newly sequenced strains, a set of mutations/genes are proposed to underlie the observed unconventional azole resistance phenotype.
Assessment of allergen tolerance breakdown levels in local and classical allergic rhinitis
Authors: Klimov A. V. , Salakhutdinova Z. V. , Naidina O. A. , Klimov V. V. , Sviridova V. S. , Pronina N. A. , Slezkin M. I.
Published: November 2022

Local allergic rhinitis, a new endotype of allergic rhinitis discerned by researchers of the Spanish Allergy School, is now in the focus of interest of international allergological community. A special feature of local allergic rhinitis, which, being similar to conventional signs of allergic rhinitis, is, however, characterized by absence of systemic atopy manifestations, e.g., an increased total serum IgE content and positive allergic skin tests. In order to assess the level of tolerance breakdown to allergens in local and classical allergic rhinitis, we have studyed concentrations of IL-4, IL-22, and IFNγ in three biological fluids, blood, nasal secretions, and skin exudate. The whole study cohort consisted of 82 patients aged 18 to 60 years with established allergic rhinitis. The diagnosis was based on counseling by allergologist/immunologist, including clinical case history and possible inheritance of atopy as well as videorhinoscopy performed by an ENT specialist. The procedure of videorhinoscopy allowed to specify allergic origin of rhinitis and exclude the patients with non-allergic forms of the disease, but it did not enable us to differentiate between the endotypes of classic and local allergic rhinitis. Subsequently, all patients have been divided into two subgroups based on the criteria of systemic atopy: (1) with a high content of serum total IgE and positive skin allergy tests (n = 41) and (2) with a significantly lower concentration of IgE and negative allergy tests (n = 41). It was concluded that the patients with classic allergic rhinitis prevailed in the 1st subgroup, whereas local rhinitis predominated in the 2nd group. The study of IL-4, IL-22 and IFNγ concentrations in the three biological fluids allowed us to presume that the 1st subgroup was characterized by increased content of IL-4 and IL-22 in blood and skin exudate in comparison with controls, and the 2nd subgroup showed a decrease in IFNγ to control values. The cytokine concentrations in nasal secretions were not representative for the subgroups studied. The result has been interpreted as the absence of tolerance breakdown to causal allergens in the patients with local allergic rhinitis at the systemic level. The obtained data could be used in development of a diagnostic biomarker system for this specific endotype of allergic rhinitis, thus avoiding potential diagnostic errors which occurred in the past, when this endotype was classified as non-allergic form of the disease, thus administering non-adequate treatment, e.g., allergen-specific immunotherapy, which could be prescribed in these cases.
CD3+CD294+T cells of the type 2 immune response: their role in allergic inflammation
Authors: Bychkova N. V.
Published: November 2022

T lymphocytes type 2 immune response protect against helminths and toxins, and also contribute to the development of allergic inflammation. One of the most specific T cell surface markers T lymphocytes 2 is the CRTH2 molecule (CD294), which is an activating receptor for prostaglandin D2. The CD3+CD294+ population is negligible in the peripheral blood of healthy individuals; an increase occurs in patients with allergic diseases and an autoimmune nature of the response. The aim of the study was to study the quantitative and functional characteristics Т lymphocytes type 2 immune response in patients with rhinoconjunctival symptoms (n = 248) and drug hypersensitivity (n = 184). In 68 patients with an elevated and extremely high number of CD3+CD294+ cells, a detailed phenotype of this population was characterized by flow cytometry and the functional activity of the studied cell population in relation to the production of interleukin 4 and interferon γ was studied using enzyme immunoassay. The control group consisted of 34 volunteers. The relative number of CD3+CD294+ cells was significantly higher in the group of patients with drug hypersensitivity – 1.6% and rhinoconjunctival symptoms 1.2% compared to the control group – 1.0%. Elevated (1.6-3.6%) and extremely high (>3.6%) CD3+CD294+ cell number were significantly more frequently detected in patients with drug hypersensitivity. In both groups, an increase in the number of CD3+CD294+ cells were observed with severe damage to the skin. The phenotype of the population T lymphocytes type 2 CD45RA-CD3+CD294+CD2+CD5+CD7+CD27+CD28+CD57-CCR7- was determined, which corresponds to effector memory T lymphocytes. With a moderately increased relative amount of this population, T lymphocytes 2 were usually represented by T helpers 2. A pronounced increase in the population was observed due to T cytotoxic lymphocytes 2. Regardless of the predominance of the Т helper or Т cytotoxic 2 cells in patients revealed an increase in spontaneous production of interleukin 4 at a normal level of interferon. An increase in the peripheral blood T lymphocytes with CD294 expression contributes to the development, maintenance and exacerbation of allergic inflammation with the participation of IgEdependent and IgE-independent mechanisms. The CD3+CD294+ cell population should be determined as an additional parameter in assessing the presence of sensitization in the basophil activation test in patients with hypersensitivity reactions. The use of this laboratory biomarker to assess the dominant type of immune inflammation will make it possible to personalize the therapy of the examined patients. Identification of pronounced deviations of indicators from the average values of a population will influence the tactics of patient management.
Role of IFNγ in pathogenesis of SARS-CoV-2 infection
Authors: Artamonov A. A. , Nikitin Yu. V. , Meshkova M. E. , Ivanov A. M.
Published: November 2022

To date, there is no consensus explaining the relationship between varying concentrations of IFNγ and the severity of infection caused by SARS-CoV-2. The aim of this article was to analyze and formulate conclusions from the selected studies and publications, which, in sum, provide a potentially reasonable view on the role of IFNγ in COVID-19 pathogenesis. This article highlights current data on the immunological role of IFNγ which affects differentiation of naive T helper cells, acting as a polarizing factor. It activates the major histocompatibility complex (MHC) class I and II, by increasing the expression of MHC I/II subunits, inhibiting replication of the viral particles by initiating activation of interferon-stimulated genes followed by subsequent synthesis of antiviral proteins. Moreover, IFNγ activates the production of cytokines by T cells, enhancing cytotoxic activity of the T killers. IFNγ exerts immunostimulatory and immunomodulatory effects via STAT1, SOCS1 and PIAS genes, thus regulating activation of the JAK-STAT signaling pathway. A number of studies were considered where the patterns of changes in serum IFNγ concentration were examined in viral infections and SARS-CoV-2. We performed a systemic analysis of the results of studies that showed a relationship between high concentrations of IFNγ and COVID-19 severity. In a number of studies, the significantly high levels of IFNγ in COVID-19 patients were often associated with a poor outcome of the disease. The median values of the IFNγ concentration in severe COVID-19 were found to be significantly higher compared to the results obtained in the cases of moderate severity. It shows an increase, in parallel with viral load in the nasopharyngeal samples upon worsening of the clinical condition. Based on the data on the decreased IFNγ concentrations in convalescent patients, the mechanism of antagonism between IFNγ and IL-4 is considered, where the decreases serum concentrations of IFNγ along with increasing level of IL-4 may be an indirect proof of normal adaptive immune response with subsequent development of antibodies to SARS-CoV-2 and gradual elimination of the virus from the body. Moreover, the evidence is discussed that the patients harboring some parasitic infections (Toxoplasma gondii, Cryptosporidium, Blastocystis hominis, Giardia duodenalis, Entamoeba histolytica) with persistently elevated level of IFNγ are at reduced risk for severe course of COVID-19.
Difusão de Programas Preventivos em Saúde Mental: Notas Teóricas
Authors: Miranda Ana Aparecida Vilela , Murta Sheila Giardini
Published: November 2022

Resumo Transtornos mentais causam incapacidades e mortes prematuras, além de representarem custos psicológico, social e econômico elevados. Embora programas de prevenção e promoção em saúde mental com evidências de efetividade estejam disponíveis, são pouco difundidos mundo afora e, em particular, no Brasil. Este artigo tem o propósito de discutir a difusão de programas de prevenção e promoção em saúde mental, segundo as lentes da Teoria da Difusão de Inovações e os desdobramentos contemporâneos. Ênfase será dada às etapas de disseminação, adoção, implementação e sustentabilidade. Implicações para o ensino, a pesquisa e a gestão são discutidas.
Organizational Justice - An Overview of the Brazilian Scientific Production
Authors: Guimarães Luisa Nogueira , Porto Juliana Barreiros , Borges-Andrade Jairo Eduardo
Published: November 2022

Abstract The relevance of organizational justice for the improvement of the relationship between workers and organizations has given the theme a prominent role on the international stage in recent decades. In Brazil, discrepancies between national and foreign contributions were pointed out by the last review on the subject, in 2005. Thus, this study analyzed the Brazilian scientific production on organizational justice, focusing on the dimensions of the organizational justice, the theoretical background, and the relationships investigated. A semi-systematic literature review was carried out in 19 journals (1996-2018). The results showed significant differences between national and international production. A national research agenda is presented, highlighting the need for studies exploring the antecedents and the effects of the process of mediation and interaction of justice and a better theoretical foundation.
Validity of the Psychological Well-Being Scale with Morbid Female Obesity
Authors: Medeiro Sandra Aparecida , França Lúcia Helena de Freitas Pinho , Hernandez José Augusto Evangelho
Published: November 2022

Abstract Psychological well-being is an important indicator of psychological adjustment. Obesity is considered a progressive disease that results in serious public health problems. This investigation sought validity evidence for the Psychological Well-Being Scale in 293 morbidly obese Brazilian women, aged between 18 and 61 years, who were awaiting bariatric surgery. The scores were submitted to Confirmatory Factor Analysis and several theoretical models were tested. According to the results, an oblique six-dimensional structure presented a good fit to the empirical data. Acceptable indices of internal consistency for the measurement factors were also obtained. The scale may contribute to the development of programs aimed at improving the psychological well-being of people with morbid obesity, before and after bariatric surgery.
Validade da Psychological Well-Being Scale com Obesidade Mórbida Feminina
Authors: Medeiro Sandra Aparecida , França Lúcia Helena de Freitas Pinho , Hernandez José Augusto Evangelho
Published: November 2022

Resumo O bem-estar psicológico é um importante indicador de ajustamento psicológico. A obesidade é considerada uma doença progressiva, que resulta em sérios problemas de saúde pública. Esta pesquisa buscou evidências de validade para a Psychological Well-Being Scale, com 293 mulheres brasileiras com obesidade mórbida, de 18 a 61 anos de idade, que aguardavam a cirurgia bariátrica. Os escores brutos foram submetidos à Análise Fatorial Confirmatória e vários modelos teóricos foram testados. Nos resultados, uma estrutura de seis dimensões oblíquas apresentou bom ajuste aos dados empíricos. Também foram obtidos índices aceitáveis de consistência interna para os fatores da medida. A escala poderá contribuir para programas que visem melhorar o bem-estar psicológico de pessoas com obesidade mórbida, antes e depois da cirurgia bariátrica.
Atenção básica: indicadores de Saúde da Mulher no Estado do Tocantins, Brasil
Authors: Brito Patrick Nunes , Pereira Tássylla Caroline Ferreira , Neves Neto Durval Nolasco das , Ribeiro Cristina Zanettini
Published: November 2022

Resumo Introdução Na região norte do Brasil observa-se a maior taxa de incidência e mortalidade por câncer de colo uterino (CCU), uma patologia 100% curável quando diagnosticada precocemente. Objetivo Este estudo visa apresentar uma análise temporo-espacial da adesão ao exame de rastreio do CCU, assim como o número de gestantes acompanhadas por agentes de saúde em domicílio, no estado do Tocantins. Método Os dados para a análise foram obtidos através da plataforma DATASUS, considerando um período de quinze anos (2001 a 2015), e foram organizados em planilhas através do software Excel. Para a avaliação espacial, ferramentas de geoprocessamento foram utilizadas, como o software Quantum GIS, com o intuito de gerar mapas temáticos. Resultados Os resultados revelaram que embora existam programas de prevenção do CCU, a adesão ao exame pelas mulheres no estado é muito inferior ao desejado. Quanto ao acompanhamento domiciliar das gestantes, a maior parte dos munícipios registrou médias acima do esperado. Conclusão Mediante ao estudo nota-se a necessidade de adotar novas medidas para melhorar a adesão ao exame preventivo do CCU, já que empregar apenas campanhas educacionais não está sendo suficientemente efetivo. Em relação ao acompanhamento das gestantes, é necessário avaliar a qualidade e não apenas a quantidade, para que seja possível uma melhor orientação e cuidado.
Compreensão dos adolescentes sobre eventos adversos relacionados à quimioterapia: um estudo de elicitação de conceitos
Authors: Silva-Rodrigues Fernanda Machado , Hinds Pamela S. , Nascimento Lucila Castanheira
Published: November 2022

Resumo Objetivo: documentar a compreensão dos adolescentes sobre os principais eventos adversos relacionados à quimioterapia a partir da versão Pediátrica dos Desfechos Relatados pelo Paciente (Patient-Reported Outcomes) dos Critérios de Terminologia Comum para Eventos Adversos (Common Terminology Criteria for Adverse Events), e assim iniciar o processo de validação dos itens desta ferramenta com adolescentes brasileiros. Método: trata-se de um estudo prospectivo, qualitativo, de elicitação de conceitos. Participaram do estudo 17 adolescentes de 13 a 18 anos, submetidos à quimioterapia em três hospitais da cidade de São Paulo-SP, Brasil. Foram realizadas entrevistas cognitivas com perguntas baseadas em eventos adversos relacionados à quimioterapia. Os dados foram analisados quanto à responsividade e ausência de resposta. Resultados: os adolescentes puderam e estavam dispostos a fornecer informações descritivas sobre seus eventos adversos quimioterápicos, incluindo eventos físicos e emocionais. Alguns participantes sugeriram nomes alternativos para os eventos adversos e alguns usaram termos mais complexos, mas a maioria ficou satisfeita com aqueles utilizados pelos pesquisadores. Conclusão: este estudo representa os primeiros passos para entender como os adolescentes com câncer identificam, nomeiam e descrevem esses eventos por meio de entrevistas cognitivas para ajudar a criar futuros instrumentos de avaliação focados nessa faixa etária.
Prevención de las autolesiones no suicidas: construcción y validación de material educativo
Authors: Silva Aline Conceição , Miasso Adriana Inocenti , Araújo Alisson , Barroso Teresa Maria Mendes Dinis de Andrade , Santos José Carlos Pereira dos , Vedana Kelly Graziani Giacchero
Published: November 2022

Resumen Objetivo: elaborar y validar un material educativo para fortalecer la asistencia en salud a los adolescentes sobre la autolesión no suicida. Método: investigación metodológica delineada en tres etapas: (1) Construcción del material a partir de un estudio mixto sobre las necesidades vinculadas al tema por medio de las redes sociales y una revisión paraguas sobre la asistencia relacionada con la autolesión no suicida; (2) validación con 10 especialistas en salud mental y/o violencia autoprovocada seleccionados por la Plataforma Lattes; (3) Evaluación por parte del público objetivo, siendo invitados profesionales de salud, sin restricción de formación. La recolección de los datos de validación y evaluación fue realizada por un cuestionario sociodemográfico y el Suitability Assessment of Materials for evaluation of health-related information for adults. Se empleó la estadística descriptiva, el índice de validez de contenido y el test AC1 de Gwet. Resultados: el material obtuvo una buena aceptación general y confiabilidad en la validación por parte de los especialistas (AC1=0,633; p = 0,0000) y en la evaluación por el público objetivo (AC1 = 0,716; p=0,0000). Todos los profesionales señalaron la contribución personal y el potencial educativo del material. Conclusión: se destaca la construcción de material educativo basado en ciencia para fortalecer la asistencia a los adolescentes con autolesión no suicida.
Enfermeiros diante do cuidado à saúde de adolescentes gays
Authors: Melo Luan Sudário , Bonelli Maria Aparecida , Ayres José Ricardo de Carvalho Mesquita , Silva Glauber Weder dos Santos , Borges Flávio Adriano , Wernet Monika
Published: November 2022

Resumo Objetivo: analisar narrativas de enfermeiros sobre o cuidado à saúde de adolescentes gays. Método: estudo qualitativo, ancorado na Análise Temática de Clarke e Braun, adotando como referencial teórico o Interacionismo Simbólico, uma vez que ele favorece a apreensão da relação de comportamentos, interações e significados sociais. Foram entrevistados remotamente 12 enfermeiros, recrutados a partir da técnica de bola de neve, por meio da plataforma de vídeo Google Meet ® . Resultados: ao longo do processo compreensivo-interpretativo, foram elaborados quatro temas: “Adolescente gay, pautas e relação com a saúde”; “A família do adolescente gay e o cuidado”; “Relação com adolescente gay no cuidado” e “Limites para o cuidar de enfermagem ao adolescente gay”. Conclusão: as narrativas denunciam estigmas e símbolos derivados da cisheteronormatividade como intervenientes da relação e indicam premência de apostas no encontro intersubjetivo com os adolescentes gays e seus familiares em relação horizontal, afetiva e empática, com chances de favorecer defesa pública do direito à saúde. Há apontamentos para a atitude dos enfermeiros e qualificação do cuidado a essa população.
Type C botulism outbreak in free-ranging waterfowl in Goiás
Authors: Martins Andressa S. , Silva Tamires A. , Rosa Isabella C.C.R. , Oliveira Alexia G.F. , Oliveira Márcio P. , Saraiva Júlia R. , Dutra Iveraldo S. , Borsanelli Ana Carolina
Published: November 2022

ABSTRACT: Botulism is generally a fatal disease caused by ingestion of neurotoxins produced by Clostridium botulinum. The present study describes the epidemiological, clinical, and laboratory aspects of a type C botulism outbreak in free-living aquatic birds residing in an urban park in Quirinópolis, Goiás, Brazil. Among a population of approximately 80 waterfowl, a total of 30 birds, including ducks (Cairina moschata), teals (Anas platyrhynchos), and geese (Anser cygnoides), died within 10 days. Of these, six birds showed signs of flaccid paralysis of the pelvic limbs, eyelids, neck, and wings. To confirm the suspicion of botulism, four lake water samples, two samples of the feed consumed by the birds, and samples of serum, intestinal content, stomach content, and liver tissue from two teals that died after presenting clinical signs were analyzed. Using bioassay and neutralization with homologous antitoxin in mice, it was possible to detect the presence of botulinum toxin type C in a water sample and in the intestinal content of one of the necropsied teals. Additionally, the presence of C. botulinum type C was identified in the lake water using polymerase chain reaction. Based on the clinical signs and laboratory results, a diagnosis of botulism caused by botulinum toxin type C was confirmed with probable transmission by lake water.
FEW Nexus (nexo alimento-energia-água) na agricultura familiar: um estudo de caso na RedeCoop/RS
Authors: Soares Henrique Martins de , Silva Tania Nunes da
Published: November 2022

Resumo: O objetivo do presente estudo foi analisar as ações da RedeCoop nas cooperativas participantes, por meio da abordagem FEW Nexus (nexo alimento-energia-água). Para isso, considerou-se uma pesquisa qualitativa e o método de pesquisa foi o estudo de caso. Adicionalmente, o método de análise escolhido foi a análise de conteúdo com categorias pré-analíticas. A coleta de dados deu-se através de entrevistas com os gestores das cooperativas e documentos, como atas, chamadas públicas e postagens em redes sociais. Ao longo da análise dos resultados, analisou-se a segurança alimentar, energética e hídrica e a produção agrícola familiar dentro do âmbito das cooperativas participantes da RedeCoop. Segundo a análise dos resultados, a RedeCoop possui ações diretas e indiretas no que tange aos elementos do nexo alimento-energia-água. Age, positivamente, nas cooperativas participantes, diretamente, nos elementos alimento e energia; e, ainda, atua indiretamente no que diz respeito ao elemento água. Nas conclusões, apresentou-se possíveis ações que podem fortalecer a atuação da RedeCoop nos elementos FEW Nexus. A presente pesquisa mostrou que a discussão do FEW Nexus poderá auxiliar a agricultura familiar sustentável. Além disso, o estudo tem a capacidade de contribuir na elaboração de políticas públicas que auxiliem na produção de alimentos feita pelos agricultores familiares.
Influence of early hemodialysis on the septic acute kidney injury outcome
Authors: Alves de Queiroz Cléria , Rodrigues Bacci Marcelo
Published: November 2022

ABSTRACT Objective: to analyze the influence of early hemodialysis on the outcome of acute septic kidney injury. Method: this is an observational, analytical, prospective study with patients diagnosed with acute septic kidney injury on hemodialysis. A questionnaire for data collection was used as an instrument. We used the Shapiro-Wilk, nonparametric Kruskal-Wallis, Mann-Whitney U, Student t and chi-square tests for analysis. Results: of the 40 patients analyzed, 60% were male, with a mean age of 55 (±16.8) years, and length of hospital stay of 43 (±26.2) days. When separating patients undergoing early and late hemodialysis into two groups, an increase in serum creatinine (p = 0.001) was observed in those who underwent late hemodialysis, however, creatinine ≥ 4mg/dl is one of the characteristics of this group. In both groups, there was a high mortality: 62.5% (10) in the early hemodialysis group and 41.7% (10) in the late hemodialysis group, with vasopressor use (p = 0.001) being the main risk factor. Conclusion: early onset of hemodialysis in acute septic kidney injury based on KDIGO definitions did not influence the outcome. However, vasopressor use associated with hemodialysis in septic patients was a predictor of death.
Influência da hemodiálise precoce no desfecho da lesão renal aguda séptica
Authors: Alves de Queiroz Cléria , Rodrigues Bacci Marcelo
Published: November 2022

RESUMO Objetivo: analisar a influência da hemodiálise precoce no desfecho da lesão renal aguda séptica. Método: estudo observacional, analítico, prospectivo, com pacientes diagnosticados com lesão renal aguda séptica em hemodiálise. Foi utilizado como instrumento um questionário para coleta de dados. Utilizaram-se para análise os testes Shapiro-Wilk, o não paramétrico de Kruskal-Wallis, U de Mann-Whitney, t de Student e do Qui-Quadrado. Resultados: dos 40 pacientes analisados, 60% eram do sexo masculino, com média de 55 (±16,8) anos, e tempo de internação hospitalar de 43 (±26,2) dias. Ao separar em dois grupos, pacientes submetidos à hemodiálise precoce e à hemodiálise tardia, observou-se naqueles que realizaram tardiamente a hemodiálise um aumento de creatinina sérica (p = 0,001), entretanto a creatinina ≥ 4mg/dl é umas das características desse grupo. Em ambos os grupos, houve uma alta mortalidade: 62,5% (10) no grupo de hemodiálise precoce e 41,7% (10) no grupo de hemodiálise tardia, sendo o uso de vasopressor (p = 0,001) o principal fator de risco. Conclusão o início precoce da hemodiálise na lesão renal aguda séptica com base nas definições do KDIGO não influenciou no desfecho. Contudo, o uso do vasopressor associado à hemodiálise em pacientes sépticos foi um fator preditor ao óbito.
NURSING STUDENTS’ LIFESTYLE AND RELATED FACTORS
Authors: Ruiz Víctor Manuel Tegoma , Lima Rayanne Branco dos Santos , Hernández José Roberto Sánchez , Zúñiga Esther Alice Jimenez , Barbosa Lorena Pinheiro
Published: November 2022

ABSTRACT Objective: to determine nursing students’ lifestyle at a university in Mexico, according to personal factors and previous behaviors of Nola J. Pender’s Health Promotion Model. Method: this is a cross-sectional study developed at a public university of Minatitlán, Veracruz, Mexico, in 2019, with nursing students enrolled in the curricular internship course, totaling 130. Data were collected that include sociodemographic, clinical and lifestyle and behavior characteristics through the Health-Promoting Lifestyle Profile I. We used Student’s t-tests, ANOVA and Pearson’s correlation for the analyses. Results: of the 130 participants, 92 (70.8%) were classified as healthy lifestyle and 38 (29.2%) had a moderately healthy lifestyle. Among the scale domains, the physical activity domain was the one with the lowest score. Negative correlations were found between the self-actualization domain and clinical variables, such as blood pressure, Body Mass Index and waist circumference, and also between this domain and the time of cell phone and television use. Conclusion: the lifestyle general classification of most participants was healthy, but the analyzes of the individual domains demonstrate the need for political and clinical interventions that influence nursing students’ health-promoting behaviors.
Campanha de prevenção de doença renal crônica: relação entre proteinúria e idosos
Authors: Nunes Filho Júlio César Chaves , Camurça David Silva , Rocha Gabriel Alves , Oliveira Ana Beatriz Timbó de , Marinho Gabriela Correia Pequeno , Santos Sérgio Gabriel Monteiro , Pereira Dyego Castelo Branco Holanda Gadelha , Meneses Gdayllon Cavalcante , Daher Elizabeth De Francesco
Published: November 2022

Resumo Objetivo: Verificar a relação entre a presença de proteinúria como marcador de lesão renal em idosos sem histórico de hipertensão arterial sistêmica e doenças cardiovasculares. Um estudo transversal foi desenvolvido de Janeiro de 2014 a Dezembro de 2019, por meio de campanhas de prevenção a doenças renais promovidas pela Universidade Federal do Ceará, na cidade de Fortaleza. Métodos: A amostra foi composta por 417 idosos. Um questionário foi usado para caracterizar indivíduos e avaliar doenças prévias, e foram utilizadas tiras reagentes de urinálise para avaliar proteinúria. Resultados: Diferenças estatisticamente significativas (p < 0,05) e tamanhos de efeito moderados foram encontrados para níveis de pressão arterial (IC 0,53-0,93), pressão arterial sistólica e pressão arterial diastólica (IC 0,21-0,61). Também foram encontradas diferenças significativas na glicemia capilar entre grupos (p = 0,033), mas com um tamanho de efeito baixo (0,02–0,42). O grupo com comorbidades apresentou 2,94 vezes mais probabilidade de ter proteinúria do que aqueles sem comorbidades (OR 2,94; IC 1,55-4,01; p < 0,05). No grupo sem doença cardiovascular/hipertensão, foi encontrada uma associação estatisticamente significativa para diabetes anterior e proteinúria (p = 0,037), apresentando risco 2,68 vezes maior de proteinúria naqueles com diabetes mellitus (OR 2,68; IC 1,05-6,85). Também foi encontrada uma associação significativa entre faixas etárias, com o grupo mais velho apresentando risco 2,69 vezes maior de desenvolver proteinúria (75 a 90 em comparação com 60 a 74 anos) (IC 1,01-7,16; p = 0,045). Conclusão: Mesmo sem hipertensão arterial sistêmica ou doença cardiovascular, o diabetes e a idade avançada podem ser considerados fatores de alto risco para proteinúria.
Chronic tinnitus: analysis of clinical contributions from different audiological evalutions
Authors: Moreira Hélinton Goulart , Bruno Rúbia Soares , Oppitz Sheila Jacques , Sanfins Milaine Dominici , Garcia Michele Vargas
Published: November 2022

ABSTRACT Purpose To investigate whether there are differences in peripheral and central audiological findings between individuals with normal hearing thresholds with and without chronic tinnitus, and thereby understand which hearing tests are most important in this population. Methods The sample was composed of convenience, including individuals from 18 to 59 years old, divided into two groups: Group 1 (G1) composed of subjects without complaints of chronic tinnitus, and Group 2 (G2) composed of individuals with chronic tinnitus. The evaluation consisted of the following procedures: Anamnesis, High-frequency audiometry (HFA), Transient Otoacoustic emissions (TOAEs), Auditory Brainstem Response (ABR)-click, Frequency Following Response (FFR), and Long Latency Auditory Evoked Potential (LLAEP)-speak. Results G2 showed increased values for HFA, with significant differences. For both groups, TOAEs showed a predominance of responses. In ABR there were no statistically significant differences. In FFR, G1 obtained a greater amplitude of wave V and there was a greater absence in LLAEP of P1, N2, and P300 in G2. Conclusion The HFA, the analysis of the wave V/I ratio in ABR, the FFR, and the LLAEP identified alterations in individuals with chronic tinnitus, demonstrating that such procedures are promising in the evaluation of this population.
Vegetative multiplication of the Atlantic Rainforest species Eugenia involucrata
Authors: Santoro Marcelo Brossi , Brogio Bruna do Amaral , Forte Mariane Jeronimo , Soares Márcio Rezende Ribeiro , Collusso Gabriel Tornisielo , Jacomino Angelo Pedro , Silva Simone Rodrigues da
Published: November 2022

Abstract The objective of this work was to evaluate air layering, cutting, and grafting, with different indolebutyric acid (IBA) rates, for the vegetative propagation of Eugenia involucrata. Air layering was carried out for two consecutive years with five different IBA rates. Cutting was tested for woody and herbaceous cuttings, using four IBA rates, in three seasons. The grafting methods – cleft graft and splice graft – were tested in two seasons. For the air layering, cutting, and grafting trials the experimental designs were randomized complete blocks, completely randomized in a 3x4 factorial arrangement, and completely randomized, respectively. Plants were evaluated for rooting, survival percentage, and shoot development. In air layering, low rooting rates of 0 to 50% were observed, the use of IBA showed no consistent results, and no resulting propagules survived after being transplanted. The cutting technique showed low survival, rooting, and leaf retention rates, with no consistent effect of IBA rates. Grafting showed 35 to 50% graft fixation, with no significant difference between the splice and cleft grafting techniques. The air layering and cutting techniques are not efficient for the propagation of E. involucrata, as they do not favor the survival and rooting of seedlings. Grafting, by both techniques, is the most efficient method for E. involucrata propagation.
Trophic assessment of four tropical reservoirs using phytoplankton genera
Authors: Rivera Carlos A. , Zapata Angela , Villamil William , León-López Nubia
Published: November 2022

Abstract: Aim Monitoring the trophic state of reservoirs requires indices that provide a quick report of the ecosystem to decision makers. This study aimed to develop a system of trophic status indicators for tropical mountain reservoirs using phytoplankton genera. Methods Between 2004 and 2010, four reservoirs for water supply in Bogotá (Colombia), which have different trophic statuses and hydraulic management, were monitored. Samples were collected for the analysis of physical and chemical variables and phytoplankton community. Through multivariate analysis, the significance of the relationships between environmental variables and phytoplankton species and genera was established. Subsequently, trophic indices were proposed as relevant variables. The global trophic index was calculated as the sum of the partial indices. Results Analysis of the main components showed that reservoirs varied chemically depending on trophic status. Phytoplankton were composed of 63 genera, 59% of which were present in the four reservoirs. Although the physical characteristics of water, such as temperature and total solids content, explained a large part of the variation in the genera, a significant relationship between the genera and variables related to trophic state was observed in each reservoir. The multivariate analyses grouping the data by genera showed a behavior similar to the analysis using information at the species level. Plankton indices of trophic state were developed for phosphorus (TP), total Kjeldahl nitrogen (TKN), total organic carbon (TOC), and Secchi disk (SD) using data grouped by genera. The indices were significantly correlated with the values of each variable in each reservoir. Linear regression models showed a significant prediction of chlorophyll-a using TP, TKN, and SD indices in the three reservoirs with the highest trophic level. In addition, the global index showed a significant relationship with variables related to the trophic state. Conclusions Phytoplankton data at the genus level can be used to assess trophic status. The models for SD, TP, and TKN could be used as indicators of the trophic status of the studied reservoirs.
The assessment of innovative geotechnical slope repair techniques
Authors: Winter Mike G. , Nettleton Ian M. , Seddon Richard , Codd James
Published: November 2022

Work to evaluate the effectiveness of innovative geotechnical slope repair techniques used on UK national highways is summarised. The techniques assessed were the planting of live willow poles, electrokinetic geosynthetics (EKG) and fibre-reinforced soil (FRS). These were used instead of conventional approaches to reduce the overall impacts of various challenges, including environmental constraints (habitat and visual) and access and utility constraints, and to reduce the scale and/or cost of traffic management and traffic delays. Trials have been undertaken over the last 20 years or so, but monitoring was generally limited to just a few years post-construction; longer term evaluation was not generally undertaken. The evaluated success – or otherwise – of the techniques led directly to recommendations for future use, ranging from the development of live willow pole design guidance and specification information, guidance on further EKG trials and cessation of the use of FRS, primarily on environmental grounds but also acknowledging the construction difficulties encountered. Life cycle analysis revealed that each technique provides significant carbon dioxide savings compared with rock fill replacement. More generic lessons learnt from the trials and the practical applications reported were used to produce guidance for future trials of innovative geotechnical repair techniques, including those for slopes.
Relationship between compressive strength and pore structure of tailings ball concrete
Authors: Li Yi , Wu Jingxiong
Published: November 2022

To study the relationship between compressive strength and pore structure of concrete under chloride and sulfate dry–wet cycles, chloride dry–wet cycle tests, sulfate dry–wet cycle tests and cube compressive strength tests were conducted for normal concrete (C) and tailings ball concrete (T) with erosion ages of 30, 60, 90, 120, 150 and 180 days. A Rapidair 457 concrete pore structure analyser was used to obtain pore structure characteristic parameters to calculate the fractal dimension and investigate the influence of erosion environment and materials on macroscopic properties and pore structure, the connection between compressive strength, pore structure and fractal dimension, and the most relevant pore structure parameters, based on the most sensitive pore size theory, to derive a multifactor compressive strength model. The results show a better compressive strength of C than T for late chloride erosion and a better compressive strength of T than C for late sulfate attack, as well as much higher correlation between the most relevant pore structure parameters and compressive strength than between a single pore structure parameter and compressive strength. The multifactor compressive strength model is consistent with the experimental results and well describes the quantitative relationship between compressive strength and pore structure under chloride and sulfate attack.
Can Kidney Organoid Xenografts Accelerate Therapeutic Development for Genetic Kidney Disorders?
Authors: Kuo Ting-Chun , Cabrera-Barragan Dalia N. , Lopez-Marfil Marta , Lopez-Cantu Diana O. , Lemos Dario R.
Published: November 2022

A number of genetic kidney diseases can now be replicated experimentally, using kidney organoids generated from human pluripotent stem cells. This methodology holds great potential for drug discovery. Under in vitro conditions, however, kidney organoids remain developmentally immature, develop scarce vasculature, and may contain undesired off-target cell types. Those critical deficiencies limit their potential as disease-modeling tools. Orthotopic transplantation under the kidney capsule improves the anatomic maturity and vascularization of kidney organoids, while reducing off-target cell content. The improvements can translate into more accurate representations of disease phenotypes and mechanisms in vivo. Recent studies using kidney organoid xenografts highlighted the unique potential of this novel methodology for elucidating molecular mechanisms driving monogenic kidney disorders and for the development ofnovel pharmacotherapies.
Asymptotic normality for kernel weighted averages estimation
Authors: Soro Brahima , Hili Ouagnina
Published: November 2022

This paper presents a set of general normality results for kernel weighted averages. We extend existing results in literature for independent data a s in Yao (2017) to stationary dependent longitudinal data. The asymptotic properties of the proposed weighted averages are investigated under \(\alpha\)-mixing conditions. These results are useful for covariance function estimation based on nonparametric kernel method.
The Parallel Universe: A Review of Webcomics
Authors: Berube Linda
Published: November 2022

Kleefeld, S., Webcomics. Bloomsbury Academic, 254 pages, 2020, ISBN 9781350028173.The review considers Webcomics, by Sean Kleefeld (Bloomsbury Academic, 2020). This volume, ranging over broad themes in sections titled Historical Overview, Social and Cultural Impact, Key Texts, and Critical Uses, is an essential text in the under-studied area of webcomics. While Webcomics provides a fresh consideration of the form’s place in digital history, historical and current works, and promoting diverse creator voices, this review maintains that an opportunity has been missed to place webcomics in the wider social and cultural context of communication and publishing. This consideration, and that of digital comics readers’ ‘lived experience’ with webcomics, points to a gap in empirical research.
The effect of emotional solidarity of local residents on tourism development support: Focusing on the near Hongdae area
Authors:   The Tourism Sciences Society Of Korea, Lee Jaehyun , Jeong Chul
Published: November 2022

As domestic tourism gains prominence today, local tourism is also undergoing change. When a community is established as a tourist destination, its members diversify, resulting in a variety of situations. Before becoming tourist destinations, communities are inhabited by the local populace. This study aims to determine the effect of emotional solidarity between locals and tourists on tourism development support. It was conducted from January 7 to February 28, 2022 via an online/offline survey of 302 Hongdae-area residents, and the following are the results of the analysis. According to the research hypothesis, emotional solidarity had a significant effect on perceived benefits, perceived costs, and community attachment, and perceived benefits, perceived costs, and community attachment had both positive (+) and negative (-) effects on government trust. Third, perceived benefits and perceived costs had a positive (+) effect on supporting tourism development, but the research hypothesis was not supported because of the negative (-) effect of community attachment. Finally, it was discovered that government trust and emotional solidarity have a positive impact on supporting tourism development, and that the theoretical and practical implications derived from this study can be used as a foundation for tourism development in the Hongdae region.
Comunicación corta notas sobre Callicore ines hopp, 1922 en Colombia y descripción de la hembra (Lepidoptera: Nymphalidae)
Authors: Salazar E. Julián A. , Pacl Václav
Published: November 2022

Este trabajo presenta registros recientes de Callicore ines (Hopp, 1922) una rara especie restringida en el piedemonte este del sur de la Cordillera Oriental de Colombia. Se consideran algunos datos taxonómicos de la especie, variación y mimetismo respecto a otros ninfálidos de la región, y se describe por primera vez la hembra que era desconocida hasta el momento.