bluuebunny/crossref_metadata_2025 huggingface dataset:
Ring chromosome 9 and chromosome 9p deletion associated with neurological and malformative syndrome
Authors: Bouzroud Wafaa , Ibenbrahim Youssra , Berrada Sarah , Maarouf Fatima , Tazzite Amal , Dehbi Hind
Published: February 2022

Ring chromosome 9 is a rare chromosomal abnormality. The severity and nature of symptoms vary according to the structural abnormalities. Here, we report a case of a patient with neurological and malformative syndrome caused by a ring of chromosome 9 associated with partial 9p deletion. The 1-year-old child had a general hypotonia at birth regressed to peripheral hypotonia and normal axial tonus, psychomotor retardation, weight retardation, microcephaly and trigonocephaly, facial dysmorphia, flattened neck, abnormal nipple spread, dorsal kyphosis, white line hernia, ectopic testis and cardiac malformation cured at the age of 1 year, no other signs detectable. The standard constitutional karyotype revealed a ring of chromosome 9 with a deletion of the region pter-22p: 46,XY,r(9)(p22;q34). The chromosomal abnormality was homogeneous. The genetic counseling remains incomplete due to the absence of the parents’ karyotype. The cardinal traits reported in the ring chromosome 9 and chromosome 9p deletion syndrome were observed in our patient such as hypotonia, psychomotor retardation, microcephaly and trigonocephaly. Indeed, the deleted region contains numerous genes involved in the neurological manifestations and cranial dysmorphia including: CER1, FREM1, NFIB, GLDC, VLDLR, FOXD4, SMARCA2 and KANK1. Microarray analysis is important in order to detect the deleted segment and thereby the deleted genes.

The ring chromosome 9 is characterized by a genotype heterogeneity and a phenotype variability that can be due to multiple factors: loss or gain of genetic material, mitotic disruption, ring chromosome instability. Genotype-phenotype correlation could provide reliable information for genetic diagnosis, genetic counseling and clinical management.

 

Keywords: Chromosome 9, Ring, Deletion, Phenotype, Genotype.
Microbiome & Autism Spectrum Disorders
Authors: El Turk Joumana
Published: February 2022

Autism Spectrum Disorders (ASD) are neurodevelopmental disorders. People with ASD have communication and social interactions difficulties along with sterotyped and repetitive behaviors (DSM-5). The symptoms are present from early childhood between 18 and 36 months, and persist into adulthood. Our body is made up of several microbiota : gut, oral, skin and vaginal. The gut microbiota is the most important because it contains 100 trillion microorganisms. Research teams have established links between dysbiosis and certain pathologies (DeGruttola A.K., et al., 2016). Several studies are being conducted to assess the effectiveness of Fecal Microbiota Transplantation (TFM) on chronic inflammatory bowel disease, metabolic disease, obesity and autism spectrum disorders (ASD). It involves introducing stool from a healthy donor into the digestive tract of a recipient patient to rebalance the host's altered gut flora. A major study of Kang et al., 2017 , on the treatment with TMP of 18 children diagnosed with ASD, aged 7 to 16 years, associated with moderate to severe gastrointestinal disturbances, showed that two years after the treatment, the intensity of the digestive disturbances decreased by 58% and the severity of typical symptoms is reduced by 47%. Sequencing analyzes showed an increase of bacterial diversity  (Kang et al., 2019) . It’s important to mention that several companies have already positioned themselves in the niche of the intestinal flora aimed at producing TMF as a drug and placing it on the market starting 2023.

Keywords: autism, ASD, microbiome, neurodevelopmental disorders
COMPETENCIA INFORMAL Y SATURACIÓN DE MERCADO DE LAS MICROEMPRESAS DEL CANTÓN CRNEL. MARCELINO MARIDUEÑA
Authors: Naula Acosta Cinthya Paola , Cadena Martínez Isabel Alison , Fabiani Orbea Bremero Leonardo
Published: February 2022

El objetivo de este artículo hace referencia a establecer de qué forma la competencia informal y la saturación de mercado influyen en las microempresas del cantón Crnel. Marcelino Maridueña, bajo un diseño metodológico cualitativo no experimental, de alcance descriptivo y correlacional; entendiendo que la competencia informal es una forma de generar ingresos para las personas que no cuentan con un empleo y realizan actividades comerciales que no se encuentran registradas legalmente, recopilando información por medio del instrumento de encuesta aplicado a los propietarios de las microempresas del cantón. De acuerdo al procedimiento desarrollado mediante la prueba de hipótesis de Pearson, se pudo determinar como resultado la relación y correlación de las variables presentadas para este estudio. Finalmente, se concluye que sí existe una relación directa entre competencia informal y saturación de mercado; con el fin de poder plantear posibles soluciones que mejoren la situación de las microempresas en el cantón Crnel Marcelino Maridueña.
Reply to Lars Olof Björn’s Comment on our article “Fundamental molecules of life are pigments which arose and co-evolved as a response to the thermodynamic imperative of dissipating the prevailing solar spectrum”
Authors: Michaelian Karo , Simeonov Aleksandar
Published: February 2022

Abstract. Lars Björn, in his critique of our article, doubts our assertion that at the origin of life the fundamental molecules of life (those in the three domains) were UVC pigments, dissipatively structured under a thermodynamic imperative to absorb and dissipate this UVC light into heat. Björn bases his critique on the suggestion that non-living material can be more photon absorbing than living material. He gives a number of examples in which he shows that the albedo of material devoid of life is lower than that of biotic material and concludes that these examples counter our assertion. However, Björn makes the erroneous assumption that albedo (reflection) is the only important factor related to photon dissipation (entropy production) occurring in the light-pigment interaction in living systems. He ignores the other contributions to entropy production due to the photon interaction which were listed in our article; 1) the shift towards the infrared of the emitted spectrum, 2) the diffuse emission and reflection of light into a greater outgoing solid angle, 3) the coupling of photon-induced evapotranspiration in the pigmented leaf to further photon dissipating processes such as the water cycle, which further allows dissipating biopigments to flourish over all of Earth’s surface. His assumption is therefore incorrect and his analysis does not provide legitimate reason for doubting our assertion that the fundamental molecules of life arose as pigments as a response to the thermodynamic imperative of dissipating the prevailing solar spectrum. In the following, we respond to each critique using the same section headings of Björn’s Comment.
Evaluating the assimilation of S5P/TROPOMI near real-time SO2 columns and layer height data into the CAMS integrated forecasting system (CY47R1), based on a case study of the 2019 Raikoke eruption
Authors: Inness Antje , Ades Melanie , Balis Dimitris , Efremenko Dmitry , Flemming Johannes , Hedelt Pascal , Koukouli Maria-Elissavet , Loyola Diego , Ribas Roberto
Published: February 2022

Abstract. The Copernicus Atmosphere Monitoring Service (CAMS), operated by the European Centre for Medium-Range Weather Forecasts on behalf of the European
Commission, provides daily analyses and 5 d forecasts of atmospheric composition, including forecasts of volcanic sulfur dioxide
(SO2) in near real time. CAMS currently assimilates total column SO2 products from the GOME-2 instruments on MetOp-B and MetOp-C and
the TROPOMI instrument on Sentinel-5P, which give information about the location and strength of volcanic plumes. However, the operational TROPOMI
and GOME-2 data do not provide any information about the height of the volcanic plumes, and therefore some prior assumptions need to be made in the
CAMS data assimilation system about where to place the resulting SO2 increments in the vertical. In the current operational CAMS
configuration, the SO2 increments are placed in the mid-troposphere, around 550 hPa or 5 km. While this gives good results
for the majority of volcanic emissions, it will clearly be wrong for eruptions that inject SO2 at very different altitudes, in particular
exceptional events where part of the SO2 plume reaches the stratosphere. A new algorithm, developed by the German Aerospace Centre (DLR) for GOME-2 and TROPOMI, optimized in the frame of the ESA-funded Sentinel-5P Innovation–SO2 Layer
Height Project, and known as the Full-Physics Inverse Learning Machine (FP_ILM) algorithm, retrieves SO2 layer height from TROPOMI in near real time (NRT) in addition
to the SO2 column. CAMS is testing the assimilation of these products, making use of the NRT layer height information to place the
SO2 increments at a retrieved altitude. Assimilation tests with the TROPOMI SO2 layer height data for the Raikoke eruption in
June 2019 show that the resulting CAMS SO2 plume heights agree better with IASI plume height data than operational CAMS runs without the
TROPOMI SO2 layer height information and show that making use of the additional layer height information leads to improved SO2
forecasts. Including the layer height information leads to higher modelled total column SO2 values
in better agreement with the satellite observations. However, the plume area and SO2 burden are generally also overestimated in the CAMS
analysis when layer height data are used. The main reason for this overestimation is the coarse horizontal resolution used in the minimizations. By
assimilating the SO2 layer height data, the CAMS system can predict the overall location of the Raikoke SO2 plume up to
5 d in advance for about 20 d after the initial eruption, which is better than with the operational CAMS configuration (without
prior knowledge of the plume height) where the forecast skill is much more reduced for longer forecast lead times.
Improved understanding of regional groundwater drought development through time series modelling: the 2018–2019 drought in the Netherlands
Authors: Brakkee Esther , van Huijgevoort Marjolein H. J. , Bartholomeus Ruud P.
Published: February 2022

Abstract. The 2018–2019 drought in north-western and central Europe caused severe damage to a wide range of sectors. It also emphasised the fact that, even in countries with temperate climates, adaptations are needed to cope with increasing future drought frequencies. A crucial component of drought management strategies is to monitor the status of groundwater resources. However, providing up-to-date assessments of regional groundwater drought development remains challenging due to the limited availability of high-quality data. This limits many studies to small selections of groundwater monitoring sites, giving an incomplete image of drought dynamics. In this study, a time series modelling-based method for data preparation was developed and applied to map the spatio-temporal development of the 2018–2019 groundwater drought in the south-eastern Netherlands, based on a large set of monitoring data. The data preparation method was evaluated for its usefulness and reliability for data validation, simulation, and regional groundwater drought assessment. The analysis showed that the 2018–2019 meteorological drought caused extreme groundwater drought throughout the south-eastern Netherlands, breaking 30-year records almost everywhere. Drought onset and duration were strongly variable in space, and higher-elevation areas suffered from severe drought well into 2020. Groundwater drought development appeared to be governed dominantly by the spatial distribution of rainfall and the landscape type. The time series modelling-based data preparation method was found to be a useful tool to enable a spatially detailed record of regional groundwater drought development. The automated time series modelling-based data validation improved the quality and quantity of useable data, although optimal validation parameters are probably context dependent. The time series simulations were generally found to be reliable; however, the use of time series simulations rather than direct measurement series can bias drought estimations, especially at a local scale, and underestimate spatial variability. Further development of time-series-based validation and simulation methods, combined with accessible and consistent monitoring data, will be valuable to enable better groundwater drought monitoring in the future.
Modelling the sequential earthquake-tsunami response of coastal urban transport infrastructure
Authors: Román-de la Sancha Azucena , Silva Rodolfo , Areu-Rangel Omar S. , Verduzco-Zapata Manuel Gerardo , Mendoza Edgar , López-Acosta Norma Patricia , Ossa Alexandra , García Silvia
Published: February 2022

Abstract. Transport networks in coastal, urban areas are extremely vulnerable to seismic events, with damage likely due to both ground motions and tsunami loading. Most existing models analyse the performance of structures under either earthquakes or tsunamis, as isolated events. This paper presents a numerical approach that captures the sequential earthquake-tsunami effects on transport infrastructure in a coastal area, taking into consideration the combined strains of the two events. Firstly, the dynamic cyclical loading is modelled, applied to the soil-structure system using a finite difference approximation to determine the differential settlement, lateral displacement, and liquefaction potential of the foundation. Next, using a finite volume method approach, tsunami wave propagation and flooding potential are modelled. Finally, the hydrostatic and hydrodynamic loads corresponding to the wave elevation are applied to the post-earthquake state of the structure, to obtain a second state of deformation. The sequential model is applied to an embankment in Manzanillo, Mexico, which is part of a main urban road, the response is analysed using ground motion records of the 1995 Manzanillo earthquake-tsunami event.
Tectonic evolution of the Indio Hills segment of the San Andreas fault in southern California
Authors: Koehl Jean-Baptiste , Bergh Steffen , Sylvester Arthur G.
Published: February 2022

Abstract. Transpressional uplift domains of inverted Miocene–Pliocene basin fill along the San Andreas fault zone in Coachella Valley, southern California, are characterized by fault linkage and segmentation and deformation partitioning. The Indio Hills wedge-shaped uplift block is located in between two boundary fault strands, the Indio Hills fault to the northeast and the Banning fault to the southwest, which merge to the southeast. Uplift commenced about 2.2–0.76 million years ago and involved progressive fold and faulting stages caused by a change from distributed strain to partly partitioned right-slip and reverse/thrust displacement on the bounding faults when approaching the fault junction. Major fold structures in the study area include oblique, right-stepping, partly overturned en echelon macro-folds that tighten and bend into parallelism with the Indio Hills fault to the east and become more open towards the Banning fault to the west, indicating an early and close relationship of the macro-folds with the Indio Hills fault and a late initiation of the Banning fault. Sets of strike-slip to reverse step-over and right- and left-lateral cross faults and conjugate kink bands affect the entire uplifted area, and locally offset the en echelon macro-folds. Comparison with the Mecca Hills and Durmid Hills uplifts farther southeast in Coachella Valley reveals notable similarities, but also differences in fault architectures, spatial and temporal evolution, and deformation mechanisms.
Cosmogenic nuclide dating of two stacked ice masses: Ong Valley, Antarctica
Authors: Bergelin Marie , Putkonen Jaakko , Balco Greg , Morgan Daniel , Corbett Lee , Bierman Paul
Published: February 2022

Abstract. We collected a debris rich ice core from a buried ice mass in Ong Valley, located in Transantarctic mountains in Antarctica. We measured cosmogenic nuclide concentrations in quartz obtained from the ice core to determine the age of the buried ice mass and infer the processes responsible for the emplacement of the debris currently overlaying the ice. Such ice masses are valuable archives of paleoclimate proxies; however, the preservation of ice beyond 800 kyrs is rare and therefore much effort has been recently focused on finding ice that is older than 1 Ma. In Ong Valley, the large, buried ice mass has been previously dated at > 1.1 Ma. Here we provide a forward model that predicts the accumulation of the cosmic-ray produced nuclides 10Be, 21Ne, and 26Al in quartz in the englacial and supraglacial debris and compare the model predictions to measured nuclide concentrations in order to further constrain the age. Large downcore variation in measured cosmogenic nuclide concentrations suggests that the englacial debris is sourced both from subglacially-derived material and recycled paleo surface debris that has experienced surface exposure prior to entrainment. We find that the upper section of the ice core is 2.95 +0.18/−0.22 Myrs. The average ice sublimation rate during this time period is 22.86 +0.10/−0.09 m Myr−1, and the surface erosion rate of the debris is 0.206 +0.013/−0.017 m Myr−1. Burial dating of the recycled paleo surface debris suggests that the lower section of the ice core belongs to a separate, older ice mass which we estimate to be 4.3–5.1 Myrs old. The ages of these two stacked, separate ice masses can be directly related to glacial advances of the Antarctic ice sheet and potentially coincide with two major global glaciations during the early and late Pliocene epoch when global temperatures and CO2 were higher than present. These ancient ice masses represent new opportunities for gathering ancient climate information.
On the measurement of stability parameter over complex mountainous terrain
Authors: Cantero Elena , Sanz Javier , Borbón Fernando , Paredes Daniel , García Almudena
Published: February 2022

Abstract. Atmospheric stability has a significant effect on wind shear and turbulence
intensity, and these variables, in turn, have a direct impact on wind power
production and loads on wind turbines. It is therefore important to know how
to characterise atmospheric stability in order to make better energy yield
estimation in a wind farm. Based on the research-grade meteorological mast at Alaiz (CENER's test site in
Navarre, Spain) named MP5, this work compares and evaluates different
instrument set-ups and methodologies for stability characterisation, namely
the Obukhov parameter, measured with a sonic anemometer, and the bulk
Richardson number based on two temperature and one wind speed measurement.
The methods are examined considering their theoretical background,
implementation complexity, instrumentation requirements, and practical use in
connection to wind energy applications. The sonic method provides a more
precise local measurement of stability while the bulk Richardson is a simpler,
robust and cost-effective technique to implement in wind assessment
campaigns. Using the sonic method as a benchmark, it is shown that to obtain
reliable bulk Richardson measurements in onshore sites it is necessary to install
one of the temperature sensors close to the ground where the temperature
gradient is stronger.
Dockless bike-sharing’s impact on mode substitution and influential factors: Evidence from Beijing, China
Authors: Chen Zheyan , Van Lierop Dea , Ettema Dick
Published: February 2022

As a newly emerged bike-sharing system, dockless bike-sharing has the potential to positively influence urban mobility by encouraging active cycling and drawing users from car, public transit and walking. However, scant empirical research explores the extent to which dockless bike-sharing replaces other travel modes for different travel purposes. There is a lack of knowledge about how dockless bike-sharing users’ personal characteristics and neighborhood environment features influence their mode substitution behaviors. Using survey data collected from residents in Beijing and geodata of land use and public transit, we conduct four multinomial logistic models to explore potential mode-substitution behaviors influenced by dockless bike-sharing for four travel purposes: work or education commuting, sports and leisure, grocery shopping, and recreational activities such as shopping, eating and drinking. The results indicate that, for the majority of respondents, dockless bike-sharing systems potentially substitute for walking or public transit. In addition, our analysis of travel attitudes points out that dockless bike-sharing not only attracts bicycle lovers but also users with a preference or positive attitude toward other travel modes. The positive association between the length of bicycle paths and the likelihood of potentially replacing public transit or motorized vehicles by dockless bike-sharing also reveals that the cycling infrastructure of residential neighborhood could be an important facilitator for users of public transit and motorized vehicles to switch to dockless bike-sharing systems.
Emilia Pardo Bazán como modelo na narrativa galega coeva (1899-1919)
Authors: Rodríguez González Olivia
Published: February 2022

Ante a cuestión de se a obra e o pensamento de Emilia Pardo Bazán foron asimilados ou rexeitados desde o comezo polo sistema literario galego, este traballo trata de responder amosando como, ao longo da súa traxectoria vital e creativa (1851-1921), a autora foi tida en conta, mesmo con carácter de referente canónico, nos momentos difíciles para os protosistemas narrativos galegos de finais do s. XIX e das primeiras décadas do s. XX. Eses momentos foron tamén decisivos para a prosecución do ronsel rexurdentista, nun caso; e noutro, para a formación do segundo Renacemento cara á definitiva narrativa galega moderna do s. XX. Dúas novelas, de «Xan de Masma» (seudónimo de Patricio Delgado Luaces) e de Vicente Risco, son aquí enfocadas no marco do comparatismo ibérico desde dous títulos de Pardo Bazán, Los Pazos de Ulloa e La sirena negra. Con estas probas tematolóxicas e metanarrativas, así como de filiación a determinadas escolas ou estéticas, etc., conclúese que houbo transferencias sistémicas que tiveron a orixe na posición que Emilia Pardo Bazán ocupaba no parnaso de escritores que estaban a forxar esa narrativa en galego.
‘FLATTENING’ THE PANDEMIC CURVE: HOW PRACTICING INFORMATION HYGIENE COULD HELP
Authors: Ligardi Lazuardyas Zhafran
Published: February 2022

This study presents an insight of the condition of infodemic in Indonesia and to provide solutions by practicing information hygiene could help in mitigating coronavirus disease (COVID-19) infodemic. Public health agencies and the WHO acknowledge infodemiology as an important new research discipline and vital area of practice during a pandemic. The purpose of this study is to provide insights into how the practice of information hygiene could also tackle the COVID-19 pandemic from the point of view of information science. In order to undertake this research, content analysis method is used with qualitative approach. This study concludes that practicing information hygiene by sanitizing before sharing is needed to overcome misinformation and disinformation.
COMMUNICATION EFFECTIVENESS AND IMAGE OF THE NATIONAL AGENCY FOR DISASTER MANAGEMENT (BNPB) IN DISSEMINATING COVID-19 INFORMATION IN INDONESIA
Authors: Sholikah Nikmatus , Anindyo Saza Azizah
Published: February 2022

Indonesia is a country that has a fairly high positive number of COVID-19 in the Asian continent.  In the context of dealing with the virus, this study aims to examine the effectiveness of the government's public relations performance in delivering messages on handling COVID-19 through BNPB Instagram, namely @bnpb_indonesia and images from BNPB.  We use the Social Network Analysis (SNA) analysis method which measures the degree of centrality, closeness centrality and betweenness centrality.  This type of descriptive qualitative research and data collection techniques used is the questionnaire method and involves 112 respondents spread across several regions in Indonesia. The results of our research conducted in April 2020 show that BNPB through the @bnpb_indonesia Instagram account has a good image.  This can be seen from the survey conducted showing that 92.9% knew about the BNPB instagram, BNPB's performance and completeness of information was ranked first out of 14 other reference instagram accounts regarding information related to COVID-19. Then the effectiveness of BNPB's communication through the @bnpb_indonesia instagram account is considered good, it can be seen from the mapping of networks on social media using the SNA method, the results of degree centrality or key actor @bnpb_Indonesia rank first of 14 information references.  Then betweeness Centrality and Eigenvector or the most connected actor is the instagram node @bnpb_indonesia, which is ranked first.
Latest Advances in Transcatheter Aortic Valve Implantation (2022)
Authors:   Department of Cardiology, St. Johannes-Hospital Dortmund, Dortmund, Germany, Tiye Vedat , Sötemann Dagmar ,   Department of Cardiology, St. Johannes-Hospital Dortmund, Dortmund, Germany, Grothusen Christina ,   Department of Cardiology, St. Johannes-Hospital Dortmund, Dortmund, Germany, Eckel Clemens ,   Department of Cardiology, St. Johannes-Hospital Dortmund, Dortmund, Germany, Becher Marc ,   Department of Cardiology, University of Bonn, Bonn, Germany, Blumenstein Johannes ,   Department of Cardiology, St. Johannes-Hospital Dortmund, Dortmund, Germany, Nef Holger ,   Department of Cardiology, University of Giessen, Giessen, Germany, Möllmann Helge ,   Department of Cardiology, St. Johannes-Hospital Dortmund, Dortmund, Germany
Published: February 2022

Since the last decade, transcatheter aortic valve implantation (TAVI) has become the treatment of choice in patients with symptomatic severe aortic stenosis (AS) who are ineligible or at higher risk for surgery. Due to the high safety profile of current device generation, TAVI has emerged as a qualified alternative to surgical aortic valve replacement (SAVR) in patients with classic aortic stenosis and intermediate surgical risk, severe bicuspid aortic valve stenosis, and isolated pure aortic regurgitation. Moderate aortic stenosis, with and without concomitant heart failure with reduced ejection fraction, are under investigation in randomized controlled clinical trials from which we will gain exciting insights on the best timing of TAVI to protect the left ventricle from further functional deterioration due to increasing AS. In these cases, a meticulous diagnostic approach including advanced imaging is becoming more and more important. Current evidence on antithrombotic strategies after TAVI is weak, contributing to poor levels of standardization and high variability in daily clinical practice. This review will provide a short overview of recent clinical trials including best timing for TAVI with moderate AS and antithrombotic strategies after TAVI with current and future TAVI generations.
Thoracic Endovascular Aortic Repair Using the C-TAG® Device with ACTIVE CONTROL System
Authors:   Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padova, Italy, Antonello Michele , Squizzato Francesco ,   Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padova, Italy, Colacchio Elda ,   Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padova, Italy, Spertino Andrea ,   Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padova, Italy, Grego Franco ,   Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padova, Italy, Piazza Michele ,   Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padova, Italy
Published: February 2022

Objective: To describe our experience with the Gore® C-TAG® endograft with ACTIVE CONTROL System (ACS) (W.L. Gore & Associates, Inc., Flagstaff, AZ, USA) in thoracic aortic repair, focusing on deployment accuracy and aortic wall apposition. Methods: All patients who underwent thoracic endovascular aortic repair (TEVAR) using the Gore® C-TAG® endograft with ACS from September 2017 to September 2021 were enrolled in a dedicated database and retrospectively analysed. We collected anatomic data on aortic arch angulation and tortuosity, proximal and distal landing zones, and the target for deployment accuracy. Proximal and distal deployment accuracies (PDA and DDA) were measured through intraoperative digital subtraction angiography (DSA), and postoperative computed tomography angiography (CTA) was required to define endograft apposition to the aortic wall. Results: Twenty-eight patients who underwent TEVAR with the Gore® C-TAG® with ACS at our institution were selected for this study: 46% presented with a type 3 aortic arch and a proximal landing zone < 3 was used in 53% of cases. Mean PDA and DDA were 1.89 ± 3.5 mm and 0.6 ± 1.4 mm, and were obtained in 93% and 100% of procedures, respectively. Mean proximal and distal wall apposition were 91 ± 17% and 98 ± 5.9%. Fifteen patients required an associated planned procedure, either to revascularize supra-aortic vessels when PLZ was < 3 or to assure optimal distal fixation with EndoAnchors™ (Medtronic, Minneapolis, MN, USA) delivery in selected cases. Two patients required reintervention during the same hospitalisation because of type 1a endoleak onset. No further reinterventions were needed during follow-up. Conclusions: Our single-centre analysis found promising results using the Gore® C-TAG® with ACS, with an optimal accuracy in deployment and wall apposition at both proximal and distal landing zones.
Análisis de los efectos electromagnéticos de la integración de un arreglo de antena de 4 elementos con la estructura de un teléfono para bandas milimétricas
Authors: Clemente Arenas Mark
Published: February 2022

Este artículo presenta un diseño de un arreglo de 4x1 antenas con alimentación microcinta coplanar gruesa de 100 Ohms que opera alrededor de los 24, 26 y 28 GHz para bandas de comunicaciones de quinta generación 5G. Los elementos que componen el arreglo son antenas de parche y las capas de cobre que utilizan la técnica de apertura de acoplamiento de multicapas para mejorar el rendimiento en lo referente a la ganancia y directividad. Utilizando herramientas de simulación se obtienen las pérdidas de retorno, el patrón de radiación, intensidad de campo y ganancia realizada. Finalmente se presenta una evaluación de los efectos en la propagación de las estructuras de teléfonos móviles actuales y de las cubiertas de protección en el campo cercano reactivo y radiante
Ószövetségi teofániák és a hívő istentapasztalat
Authors:   Pázmány Péter Katolikus Egyetem, Puskás Attila
Published: February 2022

Appoggiandosi sull’analisi fatta da George W. Savran riguardo alla struttura e tipologia delle teofanie trovatesi nell’Antico Testamento l’articolo cerca di identificare gli elementi essenziali dell’esperienza biblica su Dio che costituiscono nel loro insieme una certa criteriologia valida e modello spirituale per l’esperienza di fede e anticipano in certo senso il mistero dell’incarnazione di Cristo.
A gyermekkeresztség megengedettségi feltételei hívő és hitüket gyakorló, valamint hitüket nem (vagy csak alkalmanként) gyakorló szülők esetében
Authors:   Universitatea Babeş-Bolyai, Bakó László
Published: February 2022

The present paper discusses the conditions for liceity of infant baptism in the case of parents who live and practice their faith as well as parents who do not (or only occasionally) practice their faith. It focuses primarily on updating the Church’s legislation in this regard, analysing and evaluating it in the light of the concrete situation of families today. In doing so, I endeavour to interpret the requirements for the liceity contained in the §1 of can. 868 of the 1983 Code of Canon Law (CIC/1983) in such a way that they can be applied to the everyday situation of families in today’s society.
„Megalkuvók a papi palástban”: Ágotha Endre békemozgalmi munkássága
Authors:   Universitatea Babeş-Bolyai, Csatlós Mária
Published: February 2022

My paper introduces the Roman Catholic Church’s opposition and action routed in their political insights against the intentions of the romanian state aimed to detach the Catholic Church in Romania from Rome and organise a people’s Catholic Church. Endre Ágotha dean and parish priest of Nyárádselye has played an important role in the preparation of the schism, whom the Holy See excommunicated by excommunicatus vitandus for his work in the peace movement called Actio Catholica or „Catholic Action”. Through examining the life and work of Endre Ágotha I’m aiming to uncover the circumstances and motives of the creation of peace movement and it’s participating priests despite the explicit measures taken by the catholic clergy at Alba Iulia.
ქართული ყურძნის ჯიშებისგან წარმოებული კახური და ევროპული სტილის ღვინოების ბიოაქტიური კომპონენტების და ანტიოქსიდანტური აქტივობის შესწავლა
Authors: Makhviladze Tamari , Kartskhava George , Khachapuridze Zhuzha
Published: February 2022

In this work, the following biochemical parameters: tannins content (%), antioxidant activity mg /L-AAC-1, monomeric anthocyanins content and total polyphenols content mg/L GAE-1 in white wines 16 samples (Rkatsiteli, Msvane Kakhuri, Kisi, Khikhvi) obtained by European and Kakhetian method were studied to identify differences among variety and winemaking methods. The mentioned parameters range for tannin content from 0.067 to 0.155%, for total monomeric anthocyanin content :2.093-14.472 mg/L, for total polyphenol content 174.634-743.740 mg/L GAE-1, antioxidant activity 317.323 mg/L (AAE-1) in Kakhetian wines. While corresponding results 0.037-0.055%, 1.202-2.004 mg/L; 20.764-53.772 mg/L GAE-1; 130.702-367.935 mg/L AAC-1 are shown in European style wine. Based on the biochemical parameters of the wine, both European and Kakhetian style Kisi and Khikhvi are distinguished. A high positive correlation was observed between total polyphenol content and antioxidant activity (r2 = 0.934). However, the highest was determined in tannins-antioxidant activity and tannins-total polyphenol content (r2 = 0.957). A relatively weak correlation was found between total monomeric anthocyanin content and the antioxidant activity (r2 = 0.767) and total monomeric anthocyanin -total polyphenols (r2 = 0.767).
Quantification of Afghan Saffron’s Moisture and Main Compounds (Crocin, Picrocrocin and Safranal) for Quality Evaluation
Authors: Halim Raihana , Sherzay Najia , Faqeryar Nazifa , Hashimi M. Homayoun
Published: February 2022

Saffron, the stigmasof the plant Crocus sativusL.,hasattracted the worldwide interest for its specific organoleptic and pharmacological characteristics. Cultivation of saffron in Afghanistan began in recentyears and in very short time Afghan saffron hit higher record. Till now,there is no scientific study which has analyzed its characteristicsaccording to ISO methods. In this study, the maincomponentsof Afghan saffron have been described, and quality parameters along with its characteristics were analyzed accordingto ISO-3632-2test methods. The results of moisture analysis (5.12 to 5.74%)and determination of crocin (230.52-255.15) of Afghan saffron were at the range of standard as described for category I of saffron in ISO 3632-2 test methods. However, the results of some samples for safranal and picrocrocin (38.52-40.21 for safranal and 68.86-72.63 for picrocrocin) were higher than the range of category I of ISO 3632-2.
Epidemiology of ovarian cancer in Kazakhstan
(2013-2018)
Authors: KUKUBASOV E. K. , SATANOVA A. R. , BOLATBEKOVA R. O. , KALDIBEKOV D. B. , KURMANOVA А. А. , BERTLEUOV О. О.
Published: February 2022

Relevance: According to Globocan 2018, ovarian cancer (OC) ranks 7th among all other cancers affecting women around

the world. 295,414 new cases of OC were reported only in 2018. The incidence in Western Europe is low. The incidence in Latvia,

Poland, Lithuania, Estonia, Russia, as well as in Kazakhstan is high. In 2018, ovarian malignancies ranked 8th (3.1%) in Kazakhstan among all malignant tumours.

At that, there are no clearly recognised preventative measures to ensure the early detection of OC. 70% of ovarian malignancies are detected at stage III-IV.

The purpose of this study was to conduct a comparative analysis and assessment of the dynamics of the prevalence of OC

in the Republic of Kazakhstan in 2013-2018.

Results: The analysis of age-related OC incidence in Kazakhstan showed the presence of ovarian malignancies in all age

groups, with a marked increase by the age of 65-69 years. The majority of patients were women of the working age.

Differences were found in the incidence rates by regions of the country. In the study period, the incidence was high in Qostanai, Pavlodar, and North Kazakhstan regions (northern part of the country) and Almaty. The incidence was below the national

average in Atyrau, Jambyl, and South Kazakhstan regions (southern and western parts of the country). Recent years have witnessed a sharp increase in OC incidence in East Kazakhstan and Karaganda regions.

Conclusion: The analysis of OC prevalence in the Republic of Kazakhstan and by regions showed an increase in OC incidence. There is a marked increase in OC detection in the northern areas of the country and a decrease in the number of cases

in the south.
BARRIERS TO NUCLEAR PROLIFERATION IN THE EXPORT OF THE RUSSIAN FAST REACTORS WITH CLOSED NFC (USING EXAMPLE BREST-OD-300)
Authors: Gorin N. V. , Kuznetsov E. V. , Kuchinov V. P. , Chebeskov A. N. , Moiseev A. V. , Shidlovskiy V. V. , Krivtsov A. V.
Published: February 2022

In the coming decades, it is possible to start exporting fast reactors with a closed nuclear fuel cycle to non-nuclear-weapon countries, which will require strengthening the nuclear non-proliferation regime and increasing the effectiveness of IAEA safeguards. This can be achieved both by creating technical barriers and by improving the system of accounting and control of nuclear materials and ensuring their reliable physical protection. Using the example of the BREST-OD-300 reactor under construction as part of a pilot demonstration power complex, the analysis of design and technological features that prevent or seriously hinder the switching of nuclear materials or the use of technologies by the importing State in violation of its international obligations to produce nuclear weapons or other nuclear explosive devices has been carried out.
ANAIS I CONGRESSO NACIONAL DE CIÊNCIAS MÉDICAS E DA SAÚDE ONLINE
Authors: Soares da Silva Junielson , Holanda de Sá Gisele , Rodrigues de Oliveira Neyla Cristiane
Published: February 2022

O I Congresso Nacional de Ciências Médicas e da Saúde On-line (I CONACIMES), organizado pela Bio10 Digital Cursos, com o apoio científico da revista Journal of Education, Science and Health - JESH e do Dr. Willy França, ocorreu no período de 13 a 16 de outubro de 2021, com carga horária de 40 horas, incluindo palestras, minicursos, apresentação de trabalhos e menção honrosa.

O CONACIMES contou com a participação de graduandos, pós-graduandos, profissionais e pesquisadores da área de saúde, dos diversos cantos do Brasil e das mais variadas Instituições de Ensino e Pesquisa do país.

O evento recebeu submissões, no formato de resumos simples e expandidos. Durante a programação ocorreu exposição em e-pôster e apresentação oral, momento de debate agradável e de troca de conhecimentos que enriqueceu a experiência dos autores. Os três melhores trabalhos em cada modalidade de apresentação receberam menção honrosa. O objetivo dessa ação é incentivar a pesquisa, principalmente por autores iniciantes e estimular a produção acadêmica de graduandos, graduados e profissionais da área.

Queremos agradecer a todos os envolvidos no CONACIMES: palestrantes, avaliadores, divulgadores, participantes, monitores e todos os membros da Comissão Organizadora que possibilitaram que esse evento ocorresse.

Saibam que sem vocês não seria possível a realização do CONACIMES 2021.

Esperamos continuar com outras edições e crescendo cada vez mais.

 

Nosso muito obrigado.
THE CONCEPT OF THE TURNOVER OF NARCOTIC DRUGS AND PSYCHOTROPIC SUBSTANCES, THEIR PRECURSORS AND ANALOGUES
Authors: Huminsky M.
Published: February 2022

The article discusses the definition of the concept of "trafficking in narcotic drugs and psychotropic substances", provides a comparative legal analysis of the legislation of the CIS member states in the field of regulation of this concept, determines the trend in determining the trafficking of narcotic drugs at the level of the CIS states.
العقوبات الحدية و إدعاءات انتهاك حقوق الإنسان في النظم المعاصرة : دراسة مقارنة
Authors: طارق حسن ابن عوف
Published: February 2022

العقوبات الحدية و إدعاءات انتهاك حقوق الإنسان في النظم المعاصرة : دراسة مقارنة

This study tackles the doctrinal penalties in the Islamic penal legislation in relation to human rights in the contemporary legal systems.

The research explained the meaning of “doctrinal penalties” in the traditions of the Muslim jurists and the standpoint of the Sudanese Penal Code on the issue, then it tackled and explained each of the “doctrinal penalties” in relation to human rights with the conclusion that these penalties involve an immense consideration of human rights.

The implementation of these “doctrinal penalties” sustains the human soul, mind, honor, religion and property.

“Doctrinal penalties” are not made for vengeance or retaliation; they are prescribed out of infinite wisdom and knowledge of the human soul which could not be deterred from its evil desires and lusts save by the force of these “doctrinal penalties”.

Hence, all claims that “doctrinal penalties” violate human rights are nothing but entirely biased, unrealistic and untrue allegations which should be refuted and exposed as well as those who adopt them
O ‘direito’ de mutilar: deficiência e biopolíticas de desumanização na Palestina
Authors: Oliveira Fabio Alves Gomes , Amantino Renato
Published: February 2022

Este ensaio defende que Israel manifesta uma reivindicação implícita ao “direito de mutilar” e debilitar corpos palestinos e seus territórios como uma forma de controle biopolítico central para uma economia humanitária cientificamente autorizada. Neste contexto, o presente texto rastreia as relações que permeiam entre o viver e o morrer, que remetem ao mapeamento fundacional do biopoder em Michel Foucault – neste caso, a prática deliberada de mutilar. Ao fazer esse caminho, o texto demonstra as limitações da ideia de “dano colateral”, que desarticula os efeitos da guerra, a partir da execução da violência e observa que a política de mutilação tem empregada como uma produtiva forma de epigenética armada que perpassa a rentabilidade de uma especulativa economia reabilitativa.
Bridging the Disconnect Between Academic Institutions and Employers in the 4th Industrial Revolution
Authors: Rakowski Nicole
Published: February 2022

The skills gap is widening and causing greater inequality in the today’s workplace. Bridging the disconnect between academic institutions and employers in the 4th industrial revolution is of critical importance to the success of our current market.
Combining and analyzing both qualitative data gathered from key focus groups and a literature review, it is evident that a commitment to self- directed learning requires students and faculty to both understand the value of empowering learning, and to take increased responsibility for decision making. Academic institutions need to address skills required to become self-directed learners and must present students with the environment that lets them be more self-directed. Employers on the other hand must provide institutions with the skills they require upon hiring.
A Study on the Relationship Between Red Memorial Landscape Perception, Collective Memory, and Identity—Take the Martyrs Monument as An Example
Authors:   College of Geography and Ocean Sciences, Yanbian University, Park Road 977, Yanji, China, Xu Huimin , Jin Shizhu ,   College of Integration Science, Yanbian University, Park Road 977, Yanji, China
Published: February 2022

Landscape Perception, Memory and Identity are hot topics in landscape research and emotional research in new cultural geography. Although the relationship between the three is supported by a small number of empirical cases, there is a lack of corresponding quantitative research. In this context, the article introduces the commonly used testing methods of intermediary effects in psychology and economics to geography, takes red landscape perception as an independent variable, collective memory as an intermediary variable, and identification as a dependent variable. SPSS 22.0 and AMOS 24.0 are used to analyze the relationship between “landscape perception-collective memory-identity”. The results of the research are as follows: 1) On the whole, residents have a higher perception of the red cultural landscape, but the recognition of image appearance items varies.2) Landscape perception variables can predict collective memory variables. 3) Collective memory positively affects residents’ sense of identity. 4) Landscape perception can not only directly act on identity, but also have a positive effect on residents’ sense of identity through collective memory of residents, and part of the mediating effect played by collective memory has been verified.
Healthy living culture as management of tuberculosis
Authors: Supriyanto Supriyanto , Masrukhi Masrukhi , Suyahmo Suyahmo , Astuti Tri Marhaeni Puji
Published: February 2022

The aim of this research is to examine the concept of a healthy living culture that exists in the Semarang city community in the management of tuberculosis. The forms of healthy culture management, strengthening aspects of public education to build awareness of a healthy living culture (living in a clean environment, not smoking, exercising enough, eating enough fruits and vegetables), and eliminating negative stigma against people with tuberculosis. The culture of healthy living carried out by the people of Semarang City is carried out in the form of 1). Implement healthy living behaviors such as; living in a clean environment, do not smoke, exercising enough, eat enough fruit and vegetables. 2). Availability of health facilities that are professional and easily accessible to the public such as hospitals and health centers 3). Remove the negative stigma against people who are sick with tuberculosis. Healthy living culture is part of the complexity of cultural elements and is also a concept of life by prioritizing various life activities based on healthy actions.