bluuebunny/crossref_metadata_2025 huggingface dataset:
Transition Metals Coordination by Bis-imidazole-calix[4]arene Ligands with and Without Pyrene Units Grafted at the Large Rim
Authors: Nikšić-Franjić Ivana , Pavlović Saftić Dijana , Smrečki Vilko , Colasson Benoit , Reinaud Olivia , Piantanida Ivo , Višnjevac Aleksandar
Published: October 2024

Herein, the presented results show that previously studied DNA/RNA-interacting bis-imidazole-calix[4]arene systems can, in aqueous solutions, efficiently bind a series of biorelevant transition metal cations by coordination with the two imidazole arms at the small rim of their macrocyclic basket. The SCXRD and NMR results structurally characterised the complexes formed by referent bis-imidazole-calix[4]arene with Cu2+ and Zn2+. In solid-state (crystal), the bis-anilino derivative/Cu2+ complex, only upon exposure to the air, undergoes intramolecular dehydrogenative coupling of two neighbouring aniline units, yielding an azo bridge at the large rim of the calix[4]arene basket. In the biorelevant aqueous solution, the comparison of fluorometric titrations of referent calix[4]arene, with its analogues having one or two pyrene units grafted at the opposite (large) rim, revealed moderate-to-strong affinity towards transition metal cations, and, more importantly, a strong impact of pyrene on the binding affinity towards some cations. The pyrene arm(s) significantly diminished the affinity of the calix[4]arene-imidazole ligand towards Cu+ and strongly increased the affinity towards divalent Co2+ and Cd2+ cations. Moreover, the fluorometric response of some studied derivatives was strappingly sensitive to cation type. Since the counter-anion plays only a marginal role, such a change in selectivity is attributed to the intramolecular interaction of pyrene(s) with the calix[4]arene-imidazole system, sterically controlling the metal cation binding site.
Extremely Low-Frequency Electromagnetic Field (ELF-EMF) Increases Mitochondrial Electron Transport Chain Activities and Ameliorates Depressive Behaviors in Mice
Authors: Teranishi Masaki , Ito Mikako , Huang Zhizhou , Nishiyama Yuki , Masuda Akio , Mino Hiroyuki , Tachibana Masako , Inada Toshiya , Ohno Kinji
Published: October 2024

Compromised mitochondrial electron transport chain (ETC) activities are associated with depression in humans and rodents. However, the effects of the enhancement of mitochondrial ETC activities on depression remain elusive. We recently reported that an extremely low-frequency electromagnetic field (ELF-EMF) of as low as 10 μT induced hormetic activation of mitochondrial ETC complexes in human/mouse cultured cells and mouse livers. Chronic social defeat stress (CSDS) for 10 consecutive days caused behavioral defects mimicking depression in mice, and using an ELF-EMF for two to six weeks ameliorated them. CSDS variably decreased the mitochondrial ETC proteins in the prefrontal cortex (PFC) in 10 days, which were increased by an ELF-EMF in six weeks. CSDS had no effect on the mitochondrial oxygen consumption rate in the PFC in 10 days, but using an ELF-EMF for six weeks enhanced it. CSDS inactivated SOD2 by enhancing its acetylation and increased lipid peroxidation in the PFC. In contrast, the ELF-EMF activated the Sirt3-FoxO3a-SOD2 pathway and suppressed lipid peroxidation. Furthermore, CSDS increased markers for mitophagy, which was suppressed by the ELF-EMF in six weeks. The ELF-EMF exerted beneficial hormetic effects on mitochondrial energy production, mitochondrial antioxidation, and mitochondrial dynamics in a mouse model of depression. We envisage that an ELF-EMF is a promising therapeutic option for depression.
Waste-Derived Caffeine for Green Synthesis of Rhenium Nanoparticles with Enhanced Catalytic Activity in the Hydrogenation of 4-Nitrophenol
Authors: Kuś Alicja , Leśniewicz Anna , Dzimitrowicz Anna , Pohl Pawel , Cyganowski Piotr
Published: October 2024

Yearly, thousands of tons of wasted coffee grounds are produced according to high coffee consumption. Still, after the coffee brewing, wasted coffee grounds contain some amounts of caffeine (CAF). CAF, in turn, contains multiple O and N chelating atoms in its structure. These have a potential to be reductors for complexes of metals. In this context, within the present study, a set of CAF extracts derived from coffee beans and coffee grounds were obtained and then used for the one-step reduction of ReO4− ions with no additional toxic chemicals. Within this approach, CAF was applied as a secondary, green resource for the synthesis of unique rhenium nanoparticles (ReNPs) containing Re species at 0 and +6 oxidation states. The obtained ReNPs were identified and characterized with the use of X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM). Further, the capping and stabilization of ReNPs by CAF were verified with the aid of Fourier transformation infrared spectroscopy (FT-IR). The so-obtained “green” ReNPs were then used as a homogenous catalyst in the catalytic hydrogenation of 4-nitrophenol (4-NP). This new nanomaterial revealed a superior catalytic activity, leading to the complete reduction of 4-NP to 4-aminophenol within 40–60 min with a first-order rate constant of 0.255 min−1.
Precision Oncology in Older Cancer Patients: A Single-Center Experience
Authors: Petitat-Berli Meret , Knufinke Marie , Voegeli Michèle , Sonderegger Martina , Seifert Bettina , Chiru Elena Diana , Haeuptle Pirmin , van’t Walderveen Lisanne , Rosenberg Robert , Burri Emanuel , Subotic Svetozar , Schwab Fabienne Dominique , Dougoud-Chauvin Vérène , Unger Heinz , Mertz Kirsten , Tahan Loay , Vetter Marcus
Published: October 2024

In the last two decades, next-generation sequencing (NGS) has facilitated enormous progress in cancer medicine, in both diagnosis and treatment. However, the usefulness of NGS in older cancer patients is unclear. To determine the role of NGS in older cancer patients, we retrospectively assessed demographic, clinicopathologic, and disease-specific data from 100 randomly selected cancer patients (any subtype/stage) who underwent NGS testing in 2020 at our institution and compared the treatment outcomes (progression-free survival [PFS] and overall survival [OS]) in the younger and older patient cohorts (A [n = 34] and B [n = 66]: age < 70 and ≥70 years, respectively). Overall, 27% had targetable mutations, and 8% received NGS-determined targeted therapy (45% and 19% of patients with a targetable mutation in cohorts A and B, respectively; p = 0.2), of whom 38% (3% of the whole cohort) benefited from the therapy (PFS > 6 months). The median OS (from diagnosis) was 192 and 197 weeks in cohorts A and B, respectively (p = 0.08). This pilot study revealed no significant age-stratified difference in the diagnostic approach and treatment strategy. A small, but relevant, proportion of the cohort (3%) benefited from NGS-determined treatment. Nevertheless, older cancer patients with targetable mutations less frequently received targetable therapies.
CYP3A4*1B but Not CYP3A5*3 as Determinant of Long-Term Tacrolimus Dose Requirements in Spanish Solid Organ Transplant Patients
Authors: Concha Julia , Sangüesa Estela , Ribate María Pilar , García Cristina B.
Published: October 2024

Tacrolimus (TAC) is a commonly used immunosuppressive drug in solid organ transplantation. Pharmacogenetics has been demonstrated before to be decisive in TAC pharmacotherapy. The CYP3A5*3 variant has been reported to be the main determinant of TAC dose requirements; however, other polymorphisms have also proven to be influential, especially in CYP3A5 non-expressor patients. The aim of this study is to evaluate the influence of genetic polymorphisms in TAC therapy in a cohort of Spanish transplant recipients. Genetic analysis including ten polymorphic variants was performed, and demographic and clinical data and pharmacotherapy of 26 patients were analyzed. No significant differences were found in weight-adjusted dose between CYP3A5 expressors and non-expressors (0.047 mg/kg vs. 0.044 mg/kg), while they were found for carriers of the CYP3A4*1B allele (0.101 mg/kg; p < 0.05). The results showed that patients with at least one CYP3A4*1B allele had a higher TAC dose and lower blood concentration. Dose-adjusted TAC blood levels were also lower in CYP3A4*1B carriers compared to non-carriers (0.72 ng/mL/mg vs. 2.88 ng/mL/mg). These results support the independence of CYP3A5*3 and CYP3A4*1B variants as determinants of dose requirements despite the linkage disequilibrium present between the two. The variability in genotype frequency between ethnicities may be responsible for the discrepancy found between studies.
Participatory Renewal of Historic Districts Based on Bayesian Network
Authors: Yang Yang , Xia Yanliang , Zhao Jilong , Liu Chunlu
Published: October 2024

Public participation is a requirement for contemporary urban governance in China, especially in the protection planning of historic districts. In the rapid development stage, many historic districts have lost their functional positioning in cities and are gradually disappearing due to outdated facilities and services. Previous studies have pointed out that protecting historic and cultural districts requires the joint efforts of multiple stakeholders. Integrating multiple stakeholders’ interests and needs is a complex problem in related research fields and planning practices. The traditional forms of public participation, such as questionnaire surveys, interviews, and symposiums, have the problem of high time costs for collection and analysis. At the same time, the information has been translated multiple times, making it challenging to avoid misunderstandings and errors. Therefore, there is an urgent need for an alternative platform for public participation in the renewal of China’s historic districts. Taking Houzaimen Street in Jinan City as an example, this paper uses the Bayesian network to establish a spatial evaluation model of historic districts. Our aims are to translate natural semantics into the design semantics of the architectural field, accurately locate the spatial problems of the historic district, and provide targeted improvement measures. In this paper, a public feedback channel for Houzaimen Street is established to provide a reference for the renewal of the historic district and the advancement of public participation.
Promptology: Enhancing Human–AI Interaction in Large Language Models
Authors: Olla Phillip , Elliott Lauren , Abumeeiz Mustafa , Mihelich Karen , Olson Joshua
Published: October 2024

This study investigates the integration of generative AI in higher education and the development of the SPARRO framework, a structured approach to improving human–AI interaction in academic settings. This ethnographic study explores the integration of generative AI in healthcare and nursing education, detailing the development of the SPARRO framework based on observations of student and faculty interactions with AI tools across five courses. The study identifies key challenges such as AI hallucination, mistrust of AI-generated summaries, and the difficulty in formulating effective prompts. The SPARRO framework addresses these challenges, offering a step-by-step guide for planning, prompt design, reviewing, and refining AI outputs. While the framework shows promise in improving AI integration, future research is needed to validate its applicability across other academic disciplines and assess its long-term impact on critical thinking and academic integrity. This study contributes to the growing body of research on AI in education, offering practical solutions for ethically and effectively integrating AI tools in academic settings.
Sustainable Mobility as a Service: A Scientometric Review in the Context of Agenda 2030
Authors: Comi Antonio , Cirianni Francis M. M. , Cabras Lorenzo
Published: October 2024

City planners are facing an emergency to develop, promote, and implement actions that allow the mobility needs of people and businesses in cities (and their surroundings) to be satisfied to assure a better quality of life. Among the different actions to promote, there is public transport, which should be the cornerstone of sustainable urban mobility. The only way to achieve the transition from private to public is by integrating services into a multimodal network and then encouraging interchange between different modes of transportation. In this context, the development of mobility as a service (MaaS) solutions is significant, and different studies have been developed in recent years. The paper thus introduces a scientometric review of such a topic in relation to the Sustainable Development Goals of Agenda 2030. The study focuses on the current state of MaaS implementation, trends, and research gaps, with an in-depth analysis of emerging themes, based on 819 documents selected from the WoS and Scopus databases. Introducing the database, and research methodology, an accurate interpretation of the data generated by the bibliometric analysis, and the primary evaluation parameters are outlined. The identified studies have been then categorized into three thematic groups with the intention of offering a comprehensive study that identifies the shortcomings and difficulties in the research carried out in these areas up to today. Particular attention is paid to how this research relates to the Sustainable Development Goals.
An Efficient Ensemble Approach for Brain Tumors Classification Using Magnetic Resonance Imaging
Authors: Saeed Zubair , Torfeh Tarraf , Aouadi Souha , Ji (Jim) Xiuquan , Bouhali Othmane
Published: October 2024

Tumors in the brain can be life-threatening, making early and precise detection crucial for effective treatment and improved patient outcomes. Deep learning (DL) techniques have shown significant potential in automating the early diagnosis of brain tumors by analyzing magnetic resonance imaging (MRI), offering a more efficient and accurate approach to classification. Deep convolutional neural networks (DCNNs), which are a sub-field of DL, have the potential to analyze rapidly and accurately MRI data and, as such, assist human radiologists, facilitating quicker diagnoses and earlier treatment initiation. This study presents an ensemble of three high-performing DCNN models, i.e., DenseNet169, EfficientNetB0, and ResNet50, for accurate classification of brain tumors and non-tumor MRI samples. Our proposed ensemble model demonstrates significant improvements over various evaluation parameters compared to individual state-of-the-art (SOTA) DCNN models. We implemented ten SOTA DCNN models, i.e., EfficientNetB0, ResNet50, DenseNet169, DenseNet121, SqueezeNet, ResNet34, ResNet18, VGG16, VGG19, and LeNet5, and provided a detailed performance comparison. We evaluated these models using two learning rates (LRs) of 0.001 and 0.0001 and two batch sizes (BSs) of 64 and 128 and identified the optimal hyperparameters for each model. Our findings indicate that the ensemble approach outperforms individual models, having 92% accuracy, 90% precision, 92% recall, and an F1 score of 91% at a 64 BS and 0.0001 LR. This study not only highlights the superior performance of the ensemble technique but also offers a comprehensive comparison with the latest research.
Phishing and the Human Factor: Insights from a Bibliometric Analysis
Authors: Mutlutürk Meltem , Wynn Martin , Metin Bilgin
Published: October 2024

Academic research on the human element in phishing attacks is essential for developing effective prevention and detection strategies and guiding policymakers to protect individuals and organizations from cyber threats. This bibliometric study offers a comprehensive overview of international research on phishing and human factors from 2006 to 2024. Analysing 308 articles from the Web of Science database, a significant increase in publications since 2015 was identified, highlighting the growing importance of this field. The study revealed influential authors such as Vishwanath and Rao, leading journals like Computers & Security, and key contributing institutions including Carnegie Mellon University. The analysis uncovered strong collaborations between institutions and countries, with the USA being the most prolific and collaborative. Emerging research themes focus on psychological factors influencing phishing susceptibility, user-centric security measures, and the integration of technological solutions with human behaviour insights. The findings highlight the need for increased collaboration between academia and non-academic organizations and the exploration of industry-specific challenges. These insights offer valuable guidance for researchers, practitioners, and policymakers to advance their understanding of phishing attacks, human factors, and resource allocation in this critical aspect of digitalisation, which continues to have significant impacts across business and society at large.
Android Malware Detection Using Support Vector Regression for Dynamic Feature Analysis
Authors: Aldhafferi Nahier
Published: October 2024

Mobile devices face significant security challenges due to the increasing proliferation of Android malware. This study introduces an innovative approach to Android malware detection, combining Support Vector Regression (SVR) and dynamic feature analysis to address escalating mobile security challenges. Our research aimed to develop a more accurate and reliable malware detection system capable of identifying both known and novel malware variants. We implemented a comprehensive methodology encompassing dynamic feature extraction from Android applications, feature preprocessing and normalization, and the application of SVR with a Radial Basis Function (RBF) kernel for malware classification. Our results demonstrate the SVR-based model’s superior performance, achieving 95.74% accuracy, 94.76% precision, 98.06% recall, and a 96.38% F1-score, outperforming benchmark algorithms including SVM, Random Forest, and CNN. The model exhibited excellent discriminative ability with an Area Under the Curve (AUC) of 0.98 in ROC analysis. The proposed model’s capacity to capture complex, non-linear relationships in the feature space significantly enhanced its effectiveness in distinguishing between benign and malicious applications. This research provides a robust foundation for advancing Android malware detection systems, offering valuable insights for researchers and security practitioners in addressing evolving malware challenges.
Sentence Embeddings and Semantic Entity Extraction for Identification of Topics of Short Fact-Checked Claims
Authors: Węcel Krzysztof , Sawiński Marcin , Lewoniewski Włodzimierz , Stróżyna Milena , Księżniak Ewelina , Abramowicz Witold
Published: October 2024

The objective of this research was to design a method to assign topics to claims debunked by fact-checking agencies. During the fact-checking process, access to more structured knowledge is necessary; therefore, we aim to describe topics with semantic vocabulary. Classification of topics should go beyond simple connotations like instance-class and rather reflect broader phenomena that are recognized by fact checkers. The assignment of semantic entities is also crucial for the automatic verification of facts using the underlying knowledge graphs. Our method is based on sentence embeddings, various clustering methods (HDBSCAN, UMAP, K-means), semantic entity matching, and terms importance assessment based on TF-IDF. We represent our topics in semantic space using Wikidata Q-ids, DBpedia, Wikipedia topics, YAGO, and other relevant ontologies. Such an approach based on semantic entities also supports hierarchical navigation within topics. For evaluation, we compare topic modeling results with claims already tagged by fact checkers. The work presented in this paper is useful for researchers and practitioners interested in semantic topic modeling of fake news narratives.
Major Insect Pests of Sweet Potatoes in Brazil and the United States, with Information on Crop Production and Regulatory Pest Management
Authors: Cabral Maria J. S. , Haseeb Muhammad , Soares Marcus A.
Published: October 2024

The sweet potato [Ipomoea batatas (L.) Lam] is considered one of the most important crops in the world as food, fodder, and raw material for starch and alcohol production. Sweet potato consumption and demand for its value-added products have increased significantly over the past two decades, leading to new cultivars, expansion in acreage, and increased demand in the United States and its export markets. Due to its health benefits, sweet potato production has multiplied over the past decade in Brazil, promoting food security and economic development in rural areas. Their adaptability and nutritional value make them a food of great importance for Brazil. As pest attacks and disease infection are the main limiting aspects that often cause yield loss and quality degradation in sweet potatoes, there is a great demand to develop effective defense strategies to maintain productivity. There is a critical need for research into non-pesticide control approaches that can provide safe, cost-effective, sustainable, and environmentally friendly pest and disease management techniques. Pests which feed on roots have trade implications worldwide. For example, sweet potato tuber shipments infested with the sweet potato weevil are generally not allowed for trade in North and South America.
Impact of Climate Change on Peach Fruit Moth Phenology: A Regional Perspective from China
Authors: Bian Haotian , Yu Shengjun , Li Wenzhuo , Lu Jing , Jia Chengmin , Mao Jianxiang , Fu Qingqing , Song Yunzhe , Cai Pumo
Published: October 2024

It is widely recognized that the phenology of insects, of which the life activities are closely tied to temperature, is shifting in response to global climate warming. This study aimed to investigate the impacts of climate change on the phenology of Carposina sasakii Matsumura, 1900 (Lepidoptera: Carposinidae) across large temporal and spatial scales, through collecting and systematically analyzing historical data on the pest’s occurrence and population dynamics in China. The results showed that for overwintering adults, the first occurrence date in eastern, northwestern, and northern China has significantly advanced, along with the population peak in eastern and northwestern China. At the provincial level, the population peak date in Shandong province has also moved significantly earlier, as well as the population peak date in Shandong and Shaanxi and the end occurrence date in Ningxia. However, the population peak date in Jilin has experienced a delayed trend. For first-generation adults, the first occurrence date in northeastern, eastern, and central China has notably advanced, while the first appearance date in northwestern and northern China has significantly delayed. Additionally, the population peak in northwestern China has experienced significant delays, along with the final occurrence in northeastern and northwestern China. At the provincial level, the first occurrence date in Liaoning, Shandong, and Shanxi has significantly advanced, while Hebei has demonstrated a significant delay. The population peak time in Gansu and Shaanxi has displayed significant delays, and the end occurrence date in Liaoning, Shanxi, and Shaanxi has also shown significant delays. Furthermore, these findings integrated with the Pearson correlation results reveal spatial heterogeneity in C. sasakii’s phenological responses to climate warming at both regional and provincial scales. The phenology of C. sasakii and their changing patterns with climate warming vary by geographical location. This study provides valuable information for the future monitoring, prediction, and prevention of peach fruit moths in the context of climate warming.
Wearable Activity Trackers and Physical Activity Levels Among Members of the Athens Medical Association in Greece
Authors: Lampsas Stamatios , Marinos Georgios , Lamprinos Dimitrios , Theofilis Panagiotis , Zakynthinos George E. , Gialamas Ioannis , Lysandrou Antonios , Pililis Sotirios , Pliouta Loukia , Tzioumi Georgia , Anastasopoulou Eleni , Lambadiari Vaia , Oikonomou Evangelos , Siasos Gerasimos
Published: October 2024

Introduction: Wearable Activity Trackers (WATs) offer real-time feedback on activity levels. We assessed the impact of WAT usage on physicians’ exercise habits. Methods: Physicians from the Athens Medical Association, Greece (n = 742) responded to a self-administered questionnaire evaluating usage of WAT, demographic characteristics, specialty, and physical exercise habits. WHO guidelines recommend at least 150 min/week of moderate-intensity exercise in all healthy adults. Subjects were divided in Users of WATs (Group A), and Non-Users of WATs (Group B). This is an observational, cross-sectional study. Results: There was no difference in baseline characteristics between the two groups (age, sex, body mass index). WATs were used by 38%. Between Group A and B, there was difference in mean exercise training time (302 ± 304 min vs. 210 ± 268 min, p < 0.001), higher percentage of WHO goal achievement (66.3% vs. 50.7%, p < 0.001), and greater awareness of WHO Guidelines (59.9% vs. 47.4%, p < 0.001). WATs were mostly used by four main specialties, with higher use from Cardiologists: Cardiology (47%), Endocrinology (44%), Surgery (35%) and Internal Medicine (25%), with a p = 0.045. Finally, users of WATs compared to non-users showed higher willingness to reduce body weight (58.5% vs. 48%, p = 0.01), apply dietary restrictions (36.5% vs. 29.6%, p = 0.05), and greater motivation for weekly physical exercise (74.1% vs. 32.4%, p < 0.001); Conclusion: Physicians using WATs demonstrate increased exercise training time, greater awareness of WHO guidelines and a higher propensity to implement dietary restrictions compared to non-users. Variations in WAT usage across medical specialties emphasize the need for targeted interventions to promote physical activity and enhance healthcare professionals’ health.
Dynamics of Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Deep Neck Infection
Authors: Kim Jeong-Mi , Hoang Huu , Choi Jeong-Seok
Published: October 2024

Background: Inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), have been utilized as prognostic factors in various diseases. This study aims to evaluate changes in the NLR, PLR, and LMR in patients diagnosed with a deep neck infections (DNI) to identify useful prognostic markers. Methods: This single-center, retrospective cohort study utilized data from the electronic medical records of patients admitted to the ENT department of a tertiary university hospital between January 2000 and August 2024. Patients diagnosed with a DNI during the study period were enrolled. Preoperative and postoperative inflammatory markers were measured in all patients, and NLR, LMR, and PLR values were calculated and analyzed. Results: The post-treatment NLR was significantly lower than the pre-treatment NLR. Similarly, the post-treatment LMR was significantly higher and the post-treatment PLR was significantly lower compared to pre-treatment values. Patients admitted to the ICU had higher inflammatory markers than those in general wards. Additionally, patients with elevated inflammatory markers had longer hospital stays. Inflammatory markers were also higher in older patients and those who underwent surgical treatment. Conclusions: Significant changes in the NLR, LMR, and PLR in patients diagnosed with a DNI can serve as useful prognostic markers. These findings suggest that monitoring these markers may help to assess and improve the inflammatory status of patients, highlighting their potential role in guiding treatment.
Cough-Induced Detrusor Overactivity—Outcome after Conservative and Surgical Treatment
Authors: Villiger Anna-Sophie , Fluri Mihaela Madalina , Hoehn Diana , Radan Anda , Kuhn Annette
Published: October 2024

Background/Objectives: The most common variant of mixed urinary incontinence is stress-induced urge urinary incontinence with the correlating urodynamic findings of cough-induced detrusor overactivity (CIDO). This prospective study assessed the clinical outcomes and leakage improvement among patients with CIDO following conservative or surgical treatment. Methods: We included patients with CIDO treated at our tertiary referral center from January 2018 to July 2021 in this prospective cohort study. The detection of a detrusor contraction after a cough was diagnosed as CIDO by urodynamic multichannel testing. All the patients in our study received personalized care, with behavioral therapy and anticholinergic/betamimetic treatment as a first step. If leakage persisted, patients were given a choice between pelvic floor muscle exercises (PFMEs), periurethral bulking or a midurethral sling. The primary outcome was the mean difference in urine leakage in the pad test before and six months after treatment. Results: Thirty-five patients met the inclusion criteria for CIDO and all presented a positive pad test at baseline (mean: 27 g). All 35 patients participated in behavioral therapy and anticholinergic/betamimetic treatment. Twenty-two patients (62.9%) underwent PFME, twelve patients (34.2%) received periurethral bulking, and nine patients (25.7%) received a midurethral sling. After all the treatments, our cohort showed a significant improvement in the pad test (mean: 5.7 g, p < 0.001). The result was more favorable after periurethral bulking than the midurethral sling (p < 0.001). Conclusions: This study shows the effectiveness of conservative treatment as a first step. In cases needing further treatment, bulking agents may be superior to PFME and midurethral propylene slings, offering new perspectives in the field of urogynecology and urinary incontinence.
Kidney Stones of Type I vs. Type II Diabetic Patients: Are There Any Differences?
Authors: Pricop Cătălin , Ivănuță Marius , Nikolic Mihaela , Puia Dragoş
Published: October 2024

Background: This study highlighted the differences between the biochemical compositions of urinary stones from patients with type 1 diabetes versus those with type 2 diabetes. Materials and Methods: This study included patients diagnosed with kidney stones and diabetes who were referred to the Urological Clinic of the Dr. C. I. Parhon Hospital in Iasi from April 2017 to April 2024. We analyzed the spectroscopic stone composition from 128 lithiasis patients treated in our Clinic. In the current study, the distribution of the biochemical composition of stones varied significantly between diabetic patients with type 2 diabetes, who formed primarily mixed uric acid stones, and diabetic patients with type 1 diabetes, who mainly developed pure uric acid stones (p < 0.001). Patients with uric acid stones had significantly higher mean creatinine values than the other stone types (p < 0.001). Urinary pH levels were abnormal for all biochemical subtypes of stones, indicating acidic urine. However, patients with uric acid stones had lower pH values than the group average. From the Kaplan–Mayer analysis, patients with pure uric acid stones had a shorter time to stone recurrence compared to patients with other biochemical types identified. Conclusions: These findings, which highlight the prevalence of pure uric acid stones in patients with type 1 diabetes and the impact of this on the strategy for dissolving pure stones, represent a significant advancement in understanding urinary lithiasis in diabetic patients.
SPECT/CT Accurately Predicts Postoperative Lung Function in Patients with Limited Pulmonary Reserve Undergoing Resection for Lung Cancer
Authors: Moneke Isabelle , von Nida Christine , Senbaklavaci Oemer , Elze Mirjam , Meyer Philipp T. , Passlick Bernward , Goetz Christian , Titze Laurin
Published: October 2024

Background: Preoperative prediction of postoperative pulmonary function after anatomical resection for lung cancer is essential to prevent long-term morbidity and mortality. Here, we compared the accuracy of hybrid single-photon emission computed tomography/computed tomography (SPECT/CT) with traditional anatomical and planar scintigraphy approaches in predicting postoperative pulmonary function in patients with impaired lung function. Methods: We analyzed the predicted postoperative pulmonary function in patients undergoing major anatomical lung resection, applying a segment counting approach, planar perfusion scintigraphy (PPS), and SPECT/CT-based lung function quantification. Results: In total, 120 patients were evaluated, of whom 82 were included in the study. Postoperative lung function tests were obtained in 21 of 82 patients. The preoperative SPECT/CT-based quantification yielded very accurate results compared to the actual postoperative FEV1 and DLCO values. The linear regression analysis showed that the SPECT/CT-based analysis predicted postoperative FEV1 (%) and DLCO values more accurately than the segment counting approach or PPS. Accordingly, 58/82 patients would qualify for anatomical lung resection according to the SPECT-based quantification, 56/82 qualified according to the PPS (Mende), and only 47/82 qualified according to the segment counting method. Moreover, we noted that the SPECT-predicted FEV1 values were very close to the actual postoperative values in emphysema patients, and selected patients even showed improved lung function after surgery. Conclusions: Anatomically driven methods such as SPECT/CT yielded a very accurate prediction of the postoperative pulmonary function. Accordingly, applying SPECT/CT revealed more patients who would formally qualify for lung resection. We suggest SPECT/CT as the preferred method to evaluate eligibility for lung surgery in selected patients with impaired pulmonary reserve.
The Relationship between Inflammatory Factors, Hemoglobin, and VO2 Max in Male Amateur Long-Distance Cross-Country Skiers in the Preparation Period
Authors: Grzebisz-Zatońska Natalia
Published: October 2024

Background: Identifying factors affecting heart health in amateur athletes can significantly impact their health and help them achieve high performance. The current knowledge of these predictors is insufficient. The purpose of this study was to identify the biochemical determinants of maximal oxygen uptake (VO2 max) in male amateur long-distance cross-country skiers (37.9 ± 6.58 years, 51.08 ± 4.61 VO2 max ml/kg/min) in the preparation period. Methods: In this cross-sectional study, a time trial test was used to determine VO2 max and venous blood via biochemical markers. Descriptive statistics and Pearson correlation were used to analyze the data. The regression model determined the predictors. Results: VO2 max was significantly correlated with nine moderate or weak variables. Two regression models (R2 = 0.94 and R2 = 0.9) each identified two determinants of VO2 max, hemoglobin (p < 0.001) and C-reactive protein (p < 0.001), as well as erythrocyte sedimentation (p < 0.001) and platelets (p = 0.03). Only hemoglobin positive affected VO2 max. Conclusions: The results may indicate, in addition to results regarding hemoglobin concentration and its changes, the necessity to monitor the immune system, which may affect the capacity for amateur exercise. Biochemical monitoring is an essential tool for evaluating the individual adaptation to exercise and developing an effective training plan. The application of this knowledge can facilitate the achievement of optimal individual performance capabilities among cross-country skiing amateurs.
Extrarenal Visceral Arteries Injuries during Left Radical Nephrectomy: A 50-Year Continuing Problem
Authors: Catarci Marco , Montemurro Leonardo Antonio , Benedetti Michele , Ciano Paolo , Millarelli Massimiliano , Chiappa Roberto
Published: October 2024

Due to their proximity to the left renal hilum, injuries to the superior mesenteric artery and celiac trunk are still reported during left radical nephrectomy, whether performed via open, laparoscopic, or robotic methods. The aim of this 50-year narrative review is to emphasize the anatomical and pathophysiological bases, risk factors, and strategies for the prevention, diagnosis, and treatment of such injuries.
The Associations between Asprosine, Clusterin, Zinc Alpha-2-Glycoprotein, Nuclear Factor Kappa B, and Peroxisome Proliferator-Activated Receptor Gamma in the Development of Complications in Type 2 Diabetes Mellitus
Authors: Senyigit Abdulhalim , Durmus Sinem , Tabak Omur , Oruc Aykut , Uzun Hafize , Ekinci Iskender
Published: October 2024

Objectives: The aim of this study was to investigate the circulating levels of asprosin, clusterin, zinc-alpha-2-glycoprotein (ZAG), nuclear factor-kappa B (NF-κB), and peroxisome proliferator-activated receptor-gamma (PPAR-γ) in patients with T2DM in relation to microvascular and macrovascular complications. Measuring these biomarkers may provide insight into the pathophysiology of T2DM and indicate novel targets for the therapy of diabetes-related complications. Methods: A total of 260 subjects consisting of four groups: healthy controls (Group-1), T2DM patients without complications (Group-2), T2DM patients with microvascular complications (Group-3), and T2DM patients with macrovascular complications (Group-4). Results: The mean age of all subjects was 52.96 ± 6.4, 127 of whom were male. Asprosin, clusterin, and NF-κB levels were significantly higher, while ZAG and PPAR-γ levels were significantly lower in diabetic patients than healthy subjects (p < 0.01, for all). Asprosin (p < 0.01), clusterin (p < 0.01), and NF-κB (p: 0.002) levels were significantly higher and PPAR-γ (p < 0.01) level was significantly lower (p < 0.001) in Group-3 than Group-2. Asprosin (p < 0.01) and NF-κB (p: 0.011) levels were significantly higher while ZAG (p < 0.01) level was significantly lower in Group-4 than Group-2. Serum ZAG level was found lower in Group-4 than in Group-3 (p = 0.037). Further, the biomarkers presented significant correlation with biomarkers like HbA1c and HOMA-IR. It was observed that increasing serum asprosin, clusterin, and NF-κB levels and decreasing serum PPAR-γ levels were effective in the development of microvascular complications while the increased asprosin levels and decreased ZAG levels had a significant effect on the development of macrovascular complications in the binary logistic regression analysis. Conclusions: This study confirms that altered levels of asprosin, clusterin, ZAG, NF-κB, and PPAR-γ are associated with T2DM and its complications. These biomarkers reflect the pathophysiological processes of metabolic disturbance and inflammation in T2DM and, therefore, have the potential for use in targeted interventions to prevent and manage diabetes-related complications.
Access to Hysterectomy—What Is the Realistic Rate for Pure Vaginal Hysterectomy? A Single-Center Prospective Observational Study
Authors: Neis Felix , Ayguen Aylin , Sima Romina-Marina , Solomayer Erich-Franz , Juhasz-Boess Ingolf , Wagenpfeil Gudrun , Brandner Percy , Neis Klaus Joachim
Published: October 2024

Background/Objectives: Hysterectomy (HE) is the most common surgical procedure in gynecology worldwide. The guidelines of most countries unanimously recommend vaginal hysterectomy (VH) as the access of first choice. However, there are significant international differences in the implementation of this recommendation. Methods: In the consistent implementation of the national guidelines, the aim of this prospective observational cohort study was to evaluate how many hysterectomies can be performed vaginally under real-world conditions for benign indications excluding genital prolapse and extensive endometriosis. For this purpose, the requirements of the guidelines were implemented for all HE cases. All HEs were performed by a single, experienced surgeon. The aim was not to go to the limits of the method, but to develop a reproducible benchmark with the lowest possible complication rate. Results: From 2011 to 2020, 230 hysterectomies were performed for benign indications. A VH was performed in 146 cases (63.5%), and a laparoscopic hysterectomy (LH) in 75 cases (32.6%). An abdominal hysterectomy (AH) was only required in nine cases (3.9%). The decision for LH was made in half of the cases due to the assumed presence of endometriosis or a significantly enlarged uterus. The median duration of VH was 32 min (range 16–118 min), and the uterine weights were 15–540 g. The rate of postoperative complications of VH was 3.4%. Conclusions: In line with international guidelines, VH is possible in over 60% of cases with a short surgical time and a low complication rate. LH procedures are useful in the presence of assumed additional pathology in 35%. AH is reserved for huge uteri. A reduction in AH below 10% is possible. The global target could be a rate of 60–30–10% for VH, LH, and AH.
Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Bianconi Alessandro , Fiore Matteo , Rosso Annalisa , Acuti Martellucci Cecilia , Calò Giovanna Letizia , Cioni Giovanni , Imperiali Gianmarco , Orazi Vittorio , Tiseo Marco , Troia Anastasia , Zauli Enrico
Published: October 2024

Background: Despite the fact that thiocolchicoside has been widely used in the treatment of musculoskeletal pain, its efficacy has never been systematically evaluated. We carried out a systematic review and meta-analysis of randomized clinical trials (RCTs) to appraise the existing evidence on the efficacy of thiocolchicoside for musculoskeletal pain management. Methods: The literature search was performed on multiple databases, extracting reports of RCTs evaluating the efficacy of thiocolchicoside compared to placebo or no exposure. The reduction in pain intensity was evaluated through between-groups mean differences (MDs) in Visual Analogue Scale (VAS) scores after the intervention. The pooled effect estimates were compared to a minimally important difference (MID) of 1 point on a scale from 0 to 10. Results: We retrieved eight RCTs, including a total of 1397 patients. All the included studies were determined as being at high risk of bias. Seven trials evaluated patients with acute low back pain. After 2–3 days of treatment, the pooled MD in VAS score was −0.49 (95%CI = −0.90; −0.09) compared to controls. After 5–7 days of treatment, the summary MD was −0.82 (95%CI = −1.46; −0.18). Conclusions: Although thiocolchicoside was found to significantly reduce patient-reported low back pain, the clinical impact was very small, as the pooled effect estimates were below the MID, and the overall certainty of evidence was very low. In light of the safety concerns raised by the European Medicine Agency, an in-depth analysis on the risk–benefit balance of thiocolchicoside is required.
The Relationship between Erectile Dysfunction, Self-Esteem, and Depression in Post-Myocardial Infarction Patients
Authors: Wróblewski Oskar , Skwirczyńska Edyta , Michalczyk Kaja , Zaeir Samir , Zair Labib , Kraszewska Klara , Kiryk Julia , Bobik Alicja , Mikołajczyk-Kocięcka Anna , Chudecka-Głaz Anita
Published: October 2024

Background: The interplay between the physical and mental health of patients recovering from myocardial infarction (MI) is crucial. Erectile dysfunction (ED) is a common sexual issue, particularly among patients who have had a myocardial infarction and arterial diseases, and it significantly affects self-esteem and overall psychological well-being. Despite significant advances in cardiac rehabilitation, the psychosocial aspects, especially those related to sexual health, remain underexplored. Objectives: The objective of this study was to examine the relationship between ED, self-esteem, and depression in male patients post-MI, and to assess how ED treatment affects patients’ psychological health. Methods: This cross-sectional study involved 80 male patients with a confirmed MI within the last six months, aged between 35 and 77 years. The Beck Depression Inventory-II (BDI-II) and Rosenberg Self-Esteem Scale (SES) were used to assess psychological well-being, while the International Index of Erectile Function-5 (IIEF-5) was employed specifically to evaluate ED. Results: This study demonstrates a strong interdependence between mental and physical health in post-myocardial infarction (MI) patients, with ED being a key factor affecting self-esteem. There is a significant negative correlation between self-esteem and depression, highlighting the importance of psychological resilience in post-MI rehabilitation. Elevated self-esteem helps mitigate depressive symptoms, contributing to improved mental health and rehabilitation outcomes. Conclusions: Older patients tend to have lower self-esteem, likely due to the presence of multiple comorbidities and a longer, more challenging recovery period post-MI. Age was a significant factor in predicting lower self-esteem, but other demographic characteristics did not have a strong influence on self-esteem, depression, or ED.
Experience from a Fast-Track Multidisciplinary Clinic Integrating Movement Disorders Neurologists in Normal Pressure Hydrocephalus Evaluation
Authors: Alhusaini Saud , Sine Kathryn , Prakash Prarthana , Korthauer Laura E. , Margolis Seth A. , Chen Andrew , Rawnsley Nicole , Breen Elizabeth , Vinacco Kenneth , Weisbach Emily , Guglielmo Maria , Akbar Umer , Davis Jennifer D. , Svokos Konstantina , Klinge Petra
Published: October 2024

In this prospective observational cohort study, we provide preliminary findings from a same-day multidisciplinary fast-tracked normal pressure hydrocephalus (NPH) clinic; incorporating the expertise of movement disorders neurologists, emphasizing the clinical characteristics, consensus classification, and management of patients referred for suspected NPH. We evaluated 111 patients (male/female: 67/44) from April 2022 to May 2023. Based on the multidisciplinary team consensus, 52 (46.8%) were classified as “probable” idiopathic NPH (iNPH), 14 (12.6%) as “possible” NPH, 42 (37.8%) as “unlikely” NPH, and three (2.7%) as secondary NPH. While parkinsonian syndromes were recognized in 19.2% of “probable” iNPH patients (vs. 7.1% in “possible” and 26.2% in “unlikely” NPH), no significant group differences were noted in the scores of the UPDRS-III scale. Degenerative spine pathologies were prevalent across all NPH categories, affecting at least 50% of patients. In the “probable” iNPH group, 78.8% received programmable ventriculoperitoneal shunts, with clinical improvement identified in 87.8% at 12-month follow-up. Our findings underscore the high prevalence of overlapping and competing movement and spinal disorders in patients with suspected NPH. Further, our novel approach, incorporating movement disorder neurologists in NPH multidisciplinary evaluation, improved diagnostic precision and streamlined personalized plans, including further neurological workups, necessary spinal interventions, and medical management or rehabilitation.