bluuebunny/crossref_metadata_2025 huggingface dataset:
MOST SIMPLE EXTENSIONS OF ARE UNDECIDABLE
Authors: GALATOS NIKOLAOS , ST. JOHN GAVIN
Published: June 2021

All known structural extensions of the substructural logic
$\textbf{FL}_{\textbf{e}}$
, the Full Lambek calculus with exchange/commutativity (corresponding to subvarieties of commutative residuated lattices axiomatized by
$\{\vee , \cdot , 1\}$
-equations), have decidable theoremhood; in particular all the ones defined by knotted axioms enjoy strong decidability properties (such as the finite embeddability property). We provide infinitely many such extensions that have undecidable theoremhood, by encoding machines with undecidable halting problem. An even bigger class of extensions is shown to have undecidable deducibility problem (the corresponding varieties of residuated lattices have undecidable word problem); actually with very few exceptions, such as the knotted axioms and the other prespinal axioms, we prove that undecidability is ubiquitous. Known undecidability results for non-commutative extensions use an encoding that fails in the presence of commutativity, so and-branching counter machines are employed. Even these machines provide encodings that fail to capture proper extensions of commutativity, therefore we introduce a new variant that works on an exponential scale. The correctness of the encoding is established by employing the theory of residuated frames.
The Emergence of the Swiss Tax Haven, 1816–1914
Authors: Guex Sébastien
Published: June 2021

There is general consensus that tax havens have long played a major role in the evolution of the capitalist system on a global scale. There is also no doubt that Switzerland is one of the first, if not the first, tax haven to have emerged, as well as one of the most important in the world. However, knowledge and understanding of the history, particularly the distant past, of tax havens remains lacking, despite the considerable volume of literature devoted to them. Therefore, this article attempts to make two innovative contributions. The first is an attempt to explain the emergence of the Swiss tax haven, by analyzing the processes and factors whose intertwining led to its emergence. It thus improves the general understanding of the genesis of tax havens at an international level. The second contribution is to show that already on the eve of World War I, the Swiss Confederation possessed the necessary characteristics for a tax haven.
Northern Tepehuan
Authors: Gil Burgoin Carlos Ivanhoe
Published: June 2021

Northern Tepehuan (ISO 639-3:ntp) is one of the 68 native linguistic groups1currently spoken in Mexico according to the National Institute of Indigenous Languages (INALI 2008). As is the case with many indigenous languages, Northern Tepehuan is under serious threat of disappearance during the next decades as it is spoken by fewer than 9000 people (Carrillo 2011: 6) whose historical background has been one of social and linguistic marginalization. The Ódami – as the speakers of the language call themselves – live in the alpine valleys of an isolated region known as Sierra Tarahumara, a section of the Sierra Madre Occidental, in Chihuahua State, Mexico. Saucedo Sánchez de Tagle (2004: 6–9) indicates that the heart of the current Ódami territory is in some sections of the Guadalupe y Calvo municipality, in the southernmost tip of Chihuahua (see Figure 1) but speakers also can be found in the surrounding municipalities of Balleza, Guachochi and Batopilas. Approximately 80% of Northern Tepehuan speakers live in small villages and rural settlements around the population nuclei of Baborigame, Nabogame, Llano Grande, Barbechitos and El Venadito (Saucedo Sánchez de Tagle 2004: 7). There are also some scattered speakers living in the region’s big cities of Chihuahua and Hermosillo.
WHAT IS THE ‘ARCHANES FORMULA’? DECONSTRUCTING AND RECONSTRUCTING THE EARLIEST ATTESTATION OF WRITING IN THE AEGEAN
Authors: Ferrara Silvia , Montecchi Barbara , Valério Miguel
Published: June 2021

This article examines the earliest attestations of writing on Crete at the beginning of the second millenniumbce, the so-called ‘Archanes formula’. The aim is to reassess its origin, purpose, significance and ‘reading’ through a multi-step analysis taking in details of palaeography, correlations with iconographic seal motifs, and material culture. Key issues are considered, namely the extent to which is it comparable with the Linear A ‘libation formula’a-sa-sa-ra-me, or, conversely, whether it should be singled out as a separate writing tradition. To address these questions, the ‘Archanes formula’ is brought under close scrutiny, vis-à-vis the graphic repertoires of Cretan Hieroglyphic and, in parallel, Linear A. Our conclusions point towards a strong connection with the Cretan Hieroglyphic milieu, in terms of sign shapes and direct links to seal imagery. In this light, the earliest writing in the Aegean is revisited not so much as a script in itself, nor as a prequel to Linear A religious sequences, but as a direct manifestation of the iconic glyptic practices of the Hieroglyphic tradition.
Social network characteristics and HIV testing among older adults in South Africa
Authors: Lee Jin A. , Schafer Markus H.
Published: June 2021

Drawing from theory and research on the role of social networks in promoting or undermining preventative public health measures, this article considers how structural, compositional and functional aspects of older adults’ close social networks are associated with HIV testing in the context of rural South Africa. Analyses use data from the population-based Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) – a sample of rural adults age 40+ (N = 4,660). Results from multiple logistic regression show older South African adults with larger, more heavily non-kin and more literate networks were most likely to report testing for HIV. People whose network members provided frequent information were also most likely to be tested, though interaction effects indicate that this pattern is primarily found among those with highly literate networks. Taken together, the findings reinforce a key insight from social capital perspectives: network resourcefulness – literacy in particular – is crucial for promoting preventative health practice. The synergy between network literacy and informational support reveals the complex interplay between network characteristics in shaping health-seeking behaviour. Continued research is needed on the connection between networks and HIV testing among sub-Saharan older adults, as this population is not currently well served by many public health efforts in the region.
A multiple working mode approach to robotic hammering: Analysis and experiments
Authors: Romanyuk Vladyslav , Soleymanpour Sina , Liu Guangjun
Published: June 2021

A robot arm may be in need for performing various operations, especially for service robots and space robots. This paper presents a strategy that allows a modular and reconfigurable robot to safely perform nail hammering without hardware enhancements. The purpose is to equip a versatile robot arm with hammering capability that can be used if needed. To do this, a multiple working mode approach is applied to switch the selected joint(s) to passive mode with friction compensation to allow free rotation during impact. Analytic impulse models are used to predict joint impulses and serve as criteria for mode switching. Advantages of the proposed approach include savings on space, weight, costs, and complexity for a limited range of nail/board environments. An experimental study has validated analytic models of hammering and demonstrated the effectiveness of the proposed approach.
Effective grounding for hybrid planning problems represented in PDDL+
Authors: Scala Enrico , Vallati Mauro
Published: June 2021

Automated planning is the field of Artificial Intelligence (AI) that focuses on identifying sequences of actions allowing to reach a goal state from a given initial state. The need of using such techniques in real-world applications has brought popular languages for expressing automated planning problems to provide direct support for continuous and discrete state variables, along with changes that can be either instantaneous or durative. PDDL+ (Planning Domain Definition Language +) models support the encoding of such representations, but the resulting planning problems are notoriously difficult for AI planners to cope with due to non-linear dependencies arising from the variables and infinite search spaces. This difficulty is exacerbated by the potentially huge fully ground representations used by modern planners in order to effectively explore the search space, which can make some problems impossible to tackle.

This paper investigates two grounding techniques for PDDL+ problems, both aimed at reducing the size of the full ground representation by reasoning over the lifted, more abstract problem structure. The first method extends the simple mechanism of invariant analysis to limit the groundings of operators upfront. The second method proposes to tackle the grounding process through a PDDL+ to classical planning abstraction; this allows us to leverage the amount of research done in the classical planning area. Our empirical analysis studies the effect of these novel approaches over both real-world hybrid applications and synthetic PDDL+ problems took from standard benchmarks of the planning community; our results reveal that not only the techniques improve the running time of previous grounding mechanisms but also let the planner extend the reach to problems that were not solvable before.
Impact of Christian Orthodox Church dietary recommendations on metabolic syndrome risk factors: a scoping review
Authors: Kokkinopoulou A. , Kafatos A.
Published: June 2021

Fasting has been a practice among followers of different religions for many years. Christian Orthodox Church (COC) fasting is a periodic vegetarian-type diet in which seafood and snails are allowed on most fasting days. The present scoping review aimed to present available data regarding the benefits of COC fasting on metabolic syndrome (MetS) risk factors. Databases were searched for available studies. Twenty publications, with a total of 1226 fasting participants, provided data on the effects on different variables of MetS, including blood pressure, blood lipids and anthropometric measurements. Fasters’ diet is characterised by low saturated and trans fat intake, high complex carbohydrate and fibre consumption, due to permissible foods. COC fasting has no deficiency in essential amino acid intake since seafood and snails are allowed on fasting days. Fasters have healthier blood lipid profiles during and after COC fasting periods, and total cholesterol, LDL-cholesterol, systolic blood pressure, body weight and BMI are reduced after a fasting period. Due to restricted or forbidden intake of specific foods during the COC fasting periods, one might expect that fasters have reduced intake of macro- and micronutrients, but as shown in the available literature, there are no deficiencies. Future research on COC fasting is needed in areas not investigated at all, like MetS, before reaching definite conclusions.
Patents, Governance and Control: Ethics and the Patentability of Novel Beings and Advanced Biotechnologies in Europe
Authors: McMahon Aisling
Published: June 2021

This article focuses primarily on to what extent novel beings, and particularly, beings which display something akin to human consciousness or agency would be (or should be) patentable under current European patent law. Patents grant the patent holder a right to exclude others from using the patented invention for the period of patent grant (usually 20 years). This allows the patent holder to control how that invention can or cannot be used by others downstream, granting patent holders a governance like function over the patented technology for the duration of the patent. Accordingly, the potential for patentability of novel beings gives rise to a myriad of ethical issues including: to what extent is it appropriate for patent holders to retain and exercise patents over “novel beings”; how issues of “agency” displayed by any “novel beings” would fit within the current patent framework, if at all; and to what extent existing exclusions from patentability might exclude patents on “novel beings” or whether changes within patent law may be needed if patents in relation to “novel beings” are deemed ethically problematic. This article focuses on such issues, and in doing so, also sheds light on the role of ethical issues within the patenting of advanced biotechnologies more generally.
Lifestyle and eating habits before and during COVID-19 quarantine in Brazil
Authors: Souza Tamires CM , Oliveira Lívya A , Daniel Marina M , Ferreira Lívia G , Della Lucia Ceres M , Liboredo Juliana C , Anastácio Lucilene R
Published: June 2021

Objective:

To assess changes in daily habits, food choices and lifestyle of adult Brazilians before and during the COVID-19 pandemic.

Design:

This observational study was carried out with Brazilian adults through an online questionnaire 5 months after the social distance measures implementation. The McNemar, McNemar–Bowker and Wilcoxon tests were used to investigate differences before and during the COVID pandemic period, adopting the statistical significance of P < 0·05.

Setting:

Brazil.

Participants:

Totally, 1368 volunteers aged 18+ years.

Results:

The volunteers reported a lower frequency of breakfast, morning and lunch snacks (P < 0·05) and a higher frequency of evening snacks and other meal categories during the pandemic period (P < 0·05). The results showed an increase in the consumption of bakery products, instant meals and fast food, while the consumption of vegetables and fruits decreased (P < 0·005). There was a significant increase in the frequency of consumption of alcoholic beverages (P < 0·001), but a reduction in the dose (P < 0·001), increased frequency of smoking (P = 0·007), an increase in sleep and screen time in hours and decrease in physical activity (P < 0·001).

Conclusions:

It was possible to observe an increase in screen time, hours of sleep, smoking and drinking frequency. On the other hand, there was a reduction in the dose of alcoholic beverages but also in the practice of physical activity. Eating habits also changed, reducing the performance of daytime meals and increasing the performance of nighttime meals. The frequency of consumption of instant meals and fast food has increased, while consumption of fruits and vegetables has decreased.
Further thoughts on Asian Studies “inside-out”
Authors: Isaac Allan Punzalan , Mathew Johan , Nerlekar Anjali , Schalow Paul , Sears Tamara
Published: June 2021

In response to Sato and Sonoda's “Asian Studies ‘inside out’: research agenda for the development of Global Asian Studies,” members of the Global Asias Collaborative at Rutgers University – comprised of a diverse group of scholars of Asia and the Asian diaspora located in history, literature, art history, geography, among other disciplines – offer responses to this generative prompt to remap the place and field of “Asia” in its heterogeneous and interwoven temporalities and topologies.
It's a Long Way to the Top: Women's Ministerial Career Paths
Authors: Kroeber Corinna , Hüffelmann Joanna
Published: June 2021

Ministerial portfolios that promise high status, broad public visibility, and extensive financial and personnel resources continue to be men's domains. In this article, we shed light on gender inequality in ministerial selection processes by studying the duration from a minister's original appointment as a member of cabinet until he or she receives responsibility for a highly prestigious portfolio. We argue that the time it takes for ambitious politicians to prove themselves suitable for this type of cabinet position depends on their sex and the degree to which the policy area for which they are responsible reinforces stereotypical expectations about their personality traits. Empirical evidence from event history analysis of original data including detailed information on all ministerial careers in 27 European countries between 1990 to 2018 supports these propositions. These findings reveal that even highly qualified women politicians who are already members of the executive face additional barriers during their political careers.
How to fairly allocate scarce medical resources? Controversial preferences of healthcare professionals with different personal characteristics
Authors: Pinho Micaela , Araújo Alexandra
Published: June 2021

The scarcity of medical resources is widely recognized, and therefore priority setting is inevitable. This study examines whether Portuguese healthcare professionals (physicians vs nurses): (i) share the moral guidance proposed by ethicists and (ii) attitudes toward prioritization criteria vary among individual and professional characteristics. A sample of 254 healthcare professionals were confronted with hypothetical prioritization scenarios involving two patients distinguished by personal or health characteristics. Descriptive statistics and parametric analyses were performed to evaluate and compare the adherence of both groups of healthcare professionals regarding 10 rationing criteria: waiting time, treatment prognosis measured in life expectancy and quality of life, severity of health conditions measured in pain and immediate risk of dying, age discrimination measured in favoring the young over older and favoring the youngest over the young, merit evaluated positively or negatively, and parenthood. The findings show a slight adherence to the criteria. Waiting time and patient pain were the conditions considered fairer by respondents in contrast with the ethicists normative. Preferences for distributive justice vary by professional group and among participants with different political orientations, rationing experience, years of experience, and level of satisfaction with the NHS. Decision-makers should consider the opinion of ethicists, but also those of healthcare professionals to legitimize explicit guidelines.
Hazards and fallacies of social measurements: global indicators in the pandemic
Authors: Infantino Marta
Published: June 2021

Since the outbreak of the COVID-19 pandemic, efforts to quantitatively measure the global health situation and/or governments’ reaction vis-à-vis the pandemic have flourished. In spite of the significance of data in the fight against the pandemic, however, such global knowledge is largely questionable, insofar as it exposes itself to the many hazards and fallacies associated with global attempts to frame the social world in numbers. This is why the paper attempts to identify the hazards and fallacies most commonly associated with global measurements of social phenomena and to verify whether and to what extent these hazards and fallacies affect numerical representations of the pandemic and its effects. To this end, the paper analyses ten English-language global numerical initiatives that were launched between January and May 2020, and reviews them in light of existing critical literature on global numbers. The aim is to provide a deeper understanding of global measurements of health and related law-and-policy measures, and to suggest caution about their use as a basis for knowledge and action in the context of the pandemic.
Casualties of preparedness: the Global Health Security Index and COVID-19
Authors: Mahajan Manjari
Published: June 2021

The 2019 Global Health Security Index (GHS Index) assessed the US and the UK as the two countries best prepared to address a catastrophic pandemic. The preparedness rankings of this index have had little correlation with the actual experiences of COVID-19 in various countries. In explaining this disrepancy, the paper argues that better indicators and more data would not have fixed the problem. Rather, the prevailing paradigm of global health security that informs instruments such as the GHS Index needs to be interrogated. This dominant paradigm narrowly conceptualises global health security in terms of the availability of a technical infrastructure to detect emerging infectious diseases and prevent their contagion, but profoundly undertheorises the broader social and political determinants of public health. The neglect of social and political features is amplified in instruments such as the GHS Index that privilege universalised templates presumed to apply across countries but that prove to be inadequate in assessing how individual societies draw on their unique histories to craft public health responses.
Are Lung Ultrasound Findings in COVID-19 Pneumonia Typical or Specific?
Authors: Volpicelli Giovanni , Cardinale Luciano , Fraccalini Thomas
Published: June 2021

Abstract. The application of point-of-care lung ultrasound (LUS) in the first diagnosis and management of Corona Virus Disease 2019 (COVID-19) has gained a great interest during a pandemic that is undermining even the most advanced health systems. LUS demonstrated high sensitivity in the visualization of the interstitial signs of the typical pneumonia complicating the infection. However, although this disease gives typical lung alterations, the same LUS signs observed in COVID-19 pneumonia can be detected in other common pulmonary conditions. While being non-specific when considered separately, the analysis of the distribution of the sonographic typical signs allows the assignment of 4 LUS patterns of probability for COVID-19 pneumonia when the whole chest is examined and attention is paid to the presence of other atypical signs. Moreover, the combination of LUS likelihood with the clinical phenotype at presentation increases the accuracy. This mini-review will analyze the LUS signs of COVID-19 pneumonia and how they can be combined in patterns of probability in the first approach to suspected cases.
Do We Become More Cautious for Others When Large Amounts of Money Are at Stake?
Authors: Batteux Eleonore , Ferguson Eamonn , Tunney Richard J.
Published: June 2021

Abstract. A considerable proportion of financial decisions are made by agents acting on behalf of other people. Although people are more cautious for others when making medical decisions, this does not seem to be the case for economic decisions. However, studies with large amounts of money are particularly absent from the literature, which precludes a clear comparison to studies in the medical domain. To address this gap, we investigated the effect of outcome magnitude in two experiments where participants made choices between safe and risky options. Decision-makers were not more cautious for others over large amounts. In fact, risk-taking was accentuated for large amounts in the gain domain. We did not find self-other differences in the loss domain for either outcome magnitude. This suggests that the caution observed in medical decisions does not replicate in financial decisions with large amounts, or at least not in the same way. These results echo the concerns that have been raised about excessive risk-taking by financial agents.
The Effect of Talker Familiarity on Sentence Recognition Accuracy in Complex Noise
Authors: Buntrock Madison S. , Barker Brittan A. , Gurries Madison M. , Barrett Tyson S.
Published: June 2021

Abstract. The familiar talker advantage is the finding that a listener’s ability to perceive and understand a talker is facilitated when the listener is familiar with the talker. However, it is unclear when the benefits of familiarity emerge and whether they strengthen over time. To better understand the time course of the familiar talker advantage, we assessed the effects of long-term, implicit voice learning on 89 young adults’ sentence recognition accuracy in the presence of four-talker babble. A university professor served as the target talker in the experiment. Half the participants were students of the professor and familiar with her voice. The professor was a stranger to the remaining participants. We manipulated the listeners’ degree of familiarity with the professor over the course of a semester. We used mixed effects modeling to test for the effects of the two independent variables: talker and hours of exposure. Analyses revealed a familiar talker advantage in the listeners after 16 weeks (∼32 h) of exposure to the target voice. These results imply that talker familiarity (outside of the confines of a long-term, familial relationship) seems to be a much quicker-to-emerge, reliable cue for bootstrapping spoken language perception than previous literature suggested.
Simulation of Record Arctic Stratospheric Ozone Depletion in 2020
Authors: Grooß Jens‐Uwe , Müller Rolf
Published: June 2021

In the Arctic winter/spring of 2019/2020, stratospheric temperatures were exceptionally low until early April and the polar vortex was very stable. As a consequence, significant chemical ozone depletion occurred in the Arctic polar vortex in spring 2020. Here, we present simulations using the Chemical Lagrangian Model of the Stratosphere that address the development of chlorine compounds and ozone in the Arctic stratosphere in 2020. The simulation reproduces relevant observations of ozone and chlorine compounds, as shown by comparisons with data from the Microwave Limb Sounder, Atmospheric Chemistry Experiment‐Fourier Transform Spectrometer, balloon‐borne ozone sondes, and the Ozone Monitoring Instrument. Although the concentration of chlorine and bromine compounds in the polar stratosphere has decreased by more than 10% compared to peak values around the year 2000, the meteorological conditions in winter/spring 2019/2020 caused unprecedented ozone depletion. The lowest simulated ozone mixing ratio was about 40 ppbv. Because extremely low ozone mixing ratios were reached in the lower polar stratosphere, chlorine deactivation into HCl occurred as is normally observed in the Antarctic polar vortex. The depletion in partial column ozone in the lower stratosphere (potential temperature from 350 to 600 K, corresponding to about 12–24 km) in the vortex core was calculated to reach 143 Dobson Units, which is more than the ozone loss in 2011 and 2016, the years which —until 2020— had seen the largest Arctic ozone depletion on record.
Unknown Eruption Source Parameters Cause Large Uncertainty in Historical Volcanic Radiative Forcing Reconstructions
Authors: Marshall Lauren R. , Schmidt Anja , Johnson Jill S. , Mann Graham W. , Lee Lindsay A. , Rigby Richard , Carslaw Ken S.
Published: June 2021

Reconstructions of volcanic aerosol radiative forcing are required to understand past climate variability. Currently, reconstructions of pre‐20th century volcanic forcing are derived from sulfate concentrations measured in polar ice cores, mainly using a relationship between the average ice‐sheet sulfate deposition and stratospheric sulfate aerosol burden based on a single explosive eruption—the 1991 eruption of Mt. Pinatubo. Here we estimate volcanic radiative forcings and associated uncertainty ranges from ice‐core sulfate records of eight of the largest bipolar deposition signals in the last 2,500 years using statistical emulation of a perturbed parameter ensemble of aerosol‐climate model simulations of explosive eruptions. Extensive sampling of different combinations of eruption source parameters using the emulators reveals that a very wide range of eruptions in different seasons with different sulfur dioxide emissions, eruption latitudes, and emission altitudes produce ice‐sheet sulfate deposition consistent with ice‐core records. Consequently, we find a large range in the volcanic forcing that can be directly attributed to the unknown eruption source parameters. We estimate that the uncertainty in volcanic forcing caused by many plausible eruption realizations leads to uncertainties in the global mean surface cooling of around 1°C for the largest unidentified historical eruptions. Our emulators are available online (https://cemac.github.io/volcanic-forcing-deposition) where eruption realizations for given ice‐sheet sulfate depositions can be explored.
The Detectability Limit of Organic Molecules Within Mars South Polar Laboratory Analogs
Authors: Campbell J. D. , Schmitt B. , Brissaud O. , Muller J‐P.
Published: June 2021

A series of laboratory experiments was carried out in order to generate a diagnostic spectrum for polycyclic aromatic hydrocarbons (PAHs) of astrobiological interest in the context of the Martian South Polar Residual Cap (SPRC), to establish PAH spectral features more easily detectable in CO2 ice (mixed with small amounts of H2O ice) than the previously reported absorption feature at 3.29 µm in order to constrain their detectability limit. There is currently no existing literature on PAH detection within SPRC features, making this work novel and impactful given the recent discovery of a possible subglacial lake beneath the Martian South Pole. Although they have been detected in Martian meteorites, PAHs have not been detected yet on Mars, possibly due to the deleterious effects of ultraviolet radiation on the surface of the planet. SPRC features may provide protection to fragile molecules, and this work seeks to provide laboratory data to improve interpretation of orbital remote sensing spectroscopic imaging data. We also ascertain the effect of CO2 ice sublimation on organic spectra, as well as provide PAH reference spectra in mixtures relevant to Mars. A detectability limit of ∼0.04% has been recorded for observing PAHs in CO2 ice using laboratory instrument parameters emulating those of the Compact Reconnaissance Imaging Spectrometer for Mars, with new spectral slope features revealed between 0.7 and 1.1 µm, and absorption features at 1.14 and most sensitively, at 1.685 µm. Mars regolith analog mixed with a concentration of 1.5% PAHs resulted in no discernible organic spectral features. These detectability limits measured in the laboratory are discussed and extrapolated to the effective conditions on the Mars South Polar Cap in terms of dust and water ice abundance and CO2 ice grain size for both the main perennial cap and the H2O ice‐dust sublimation lag deposit.
Driving Mechanisms of Sedimentary 230Th and 231Pa Variability in the Western Arctic Ocean Through the Last Glacial Cycle
Authors: Xu Qian , Xiao Wenshen , Wang Rujian , Süfke Finn , Lippold Jörg , Not Christelle
Published: June 2021

Concentration profiles of excess 230Th and 231Pa (230Thxs and 231Paxs) in Arctic Ocean sediment cores exhibit strong temporal variabilities, but the mechanisms responsible for the variabilities remain poorly understood. Here, we present new 230Thxs and 231Paxs profiles from the Mendeleev Ridge to examine downcore 230Thxs and 231Paxs distributions and their connection to environmental conditions in the Arctic. Measurable concentrations of 230Thxs(231Paxs) from the new record display an alternation of “230Thxs(231Paxs)‐rich” and “230Thxs(231Paxs)‐poor” sections as observed in the other cores from the Mendeleev Ridge. Sedimentary characteristics reveal that this alternation does not directly correspond to interglacial‐glacial cycles. The 230Thxs and 231Paxs concentrations show an inverse relationship to their corresponding sedimentation rates, suggesting the distributions of 230Thxs and 231Paxs are affected by variable dilution with terrigenous material. However, changes in lateral transport of these isotopes may also account for the observed oscillations. Sedimentary cumulative inventories of 230Thxs show evidence for a net deficit of 230Th in the sediments during the last glacial period, possibly due to a lack of scavenging material in general.
Forward Modeling of the Phobos Tides and Applications to the First Martian Year of the InSight Mission
Authors: Pou L. , Nimmo F. , Lognonné P. , Mimoun D. , Garcia R. F. , Pinot B. , Rivoldini A. , Banfield D. , Banerdt W. B.
Published: June 2021

The tidal response of Mars, due to the Sun and the Martian moons, Phobos and Deimos, provides information about the interior structure of Mars. By using the Very Broad Band (VBB) seismometer of Seismic Experiment for Interior Structure (SEIS) as a gravimeter on the surface of Mars, the InSight mission will provide the long‐period data suited to tidal analysis: most notably, the proximity of Phobos implies that degree 2, 3, 4, and further tides will be detectable by the VBB and are expected to provide information about the rheology at different depths within Mars. In order to expedite the recovery of these tidal signals in the SEIS measurements, we model the tides raised by Phobos using a tidal potential deduced from JPL Horizons ephemerides. From this potential, we calculate the expected tidal acceleration at InSight's location and gravimetric factors using a set of plausible interior models of Mars. To simulate the expected long period signal on the VBB seismometer, we use the InSight Auxiliary Payload Sensor Suite data to model the noise seen at low frequency by SEIS mainly due to temperature and pressure variations. Based on this synthetic signal, by applying filtering methods such as stacking and matched filtering to these synthetic data, we show that by recovering the gravimetric factors, it should be possible to constrain the state of the core and its size with an accuracy of 125 km after two Earth years.
A ∼12 Myr Miocene Record of East Asian Monsoon Variability From the South China Sea
Authors: Holbourn Ann , Kuhnt Wolfgang , Clemens Steven C. , Heslop David
Published: June 2021

The long‐term evolution of the East Asian Monsoon and the processes controlling its variability under changing climate boundary conditions remain enigmatic. Here, we integrate new and published high‐resolution planktic and benthic foraminiferal isotope data with proxy records for chemical weathering derived from diffuse reflectance spectroscopy at Ocean Drilling Program Site 1146 (South China Sea) to reconstruct the evolution of the summer monsoon between ∼17 and 5 Ma. Our records show that an overall warm and humid tropical climate prevailed over southeastern Asia during the Miocene Climatic Optimum, suggesting northward expansion of the tropical rain belt in response to greenhouse gas forcing. By contrast, monsoon seasonality increased during the middle Miocene Climatic Transition in tandem with Antarctic glacial expansion and global cooling. Substantial weakening of the summer monsoon between ∼12.7 and 10.9 Ma supports that decreased weathering and riverine input of nutrients and alkalinity contributed to carbonate depletion in the deep ocean during the Carbonate Crash. Intensification of monsoonal circulation and strengthening of the biological pump through the late Miocene promoted carbon burial, drawdown of atmospheric CO2, and climate cooling during the Biogenic Bloom. These results underscore the dynamic evolution of the East Asian Monsoon throughout the middle to late Miocene. Variations in local insolation forcing and in Southern Hemisphere ice volume, influencing the latitudinal thermal gradient, evaporation‐moisture budgets, and the strength of the tropical convection, exerted major controls on the development of the monsoon.
External cervical resorption—a review of pathogenesis and potential predisposing factors
Authors: Chen Yiming , Huang Ying , Deng Xuliang
Published: June 2021

External cervical resorption (ECR) refers to a pathological state in which resorption tissues penetrate into the dentin at the cervical aspect of the root. Despite being latent in its initial phase, ECR could cause severe damage to mineralized dental tissue and even involve the pulp if not given timely diagnosis and treatment. Nevertheless, the etiology of ECR is still poorly understood, which adds to the difficulty in early diagnosis. ECR has received growing attention in recent years due to the increasing number of clinical cases. Several potential predisposing factors have been recognized in cross-sectional studies as well as case reports. In the meantime, studies on histopathology and pathogenesis have shed light on possible mechanisms of ECR. This review aims to summarize the latest findings in the pathogenesis and potential predisposing factors of ECR, so as to provide pragmatic reference for clinical practice.
Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice
Authors: Dao Nigel C. , Brockway Dakota F. , Suresh Nair Malini , Sicher Avery R. , Crowley Nicole A.
Published: June 2021

Somatostatin (SST) neurons have been implicated in a variety of neuropsychiatric disorders such as depression and anxiety, but their role in substance use disorders, including alcohol use disorder (AUD), is not fully characterized. Here, we found that repeated cycles of alcohol binge drinking via the Drinking-in-the-Dark (DID) model led to hypoactivity of SST neurons in the prelimbic (PL) cortex by diminishing their action potential firing capacity and excitatory/inhibitory transmission dynamic. We examined their role in regulating alcohol consumption via bidirectional chemogenetic manipulation. Both hM3Dq-induced excitation and KORD-induced silencing of PL SST neurons reduced alcohol binge drinking in males and females, with no effect on sucrose consumption. Alcohol binge drinking disinhibited pyramidal neurons by augmenting SST neurons-mediated GABA release and synaptic strength onto other GABAergic populations and reducing spontaneous inhibitory transmission onto pyramidal neurons. Pyramidal neurons additionally displayed increased intrinsic excitability. Direct inhibition of PL pyramidal neurons via hM4Di was sufficient to reduce alcohol binge drinking. Together these data revealed an SST-mediated microcircuit in the PL that modulates the inhibitory dynamics of pyramidal neurons, a major source of output to subcortical targets to drive reward-seeking behaviors and emotional response.
Correction: Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity
Authors: Meaden Sean , Capria Loris , Alseth Ellinor , Gandon Sylvain , Biswas Ambarish , Lenzi Luca , van Houte Stineke , Westra Edze R
Published: June 2021

A Correction to this paper has been published: https://doi.org/10.1038/s41396-020-00846-1
Degradation of biological macromolecules supports uncultured microbial populations in Guaymas Basin hydrothermal sediments
Authors: Pérez Castro Sherlynette , Borton Mikayla A , Regan Kathleen , Hrabe de Angelis Isabella , Wrighton Kelly C , Teske Andreas P , Strous Marc , Ruff S Emil
Published: June 2021

Hydrothermal sediments contain large numbers of uncultured heterotrophic microbial lineages. Here, we amended Guaymas Basin sediments with proteins, polysaccharides, nucleic acids or lipids under different redox conditions and cultivated heterotrophic thermophiles with the genomic potential for macromolecule degradation. We reconstructed 20 metagenome-assembled genomes (MAGs) of uncultured lineages affiliating with known archaeal and bacterial phyla, including endospore-forming Bacilli and candidate phylum Marinisomatota. One Marinisomatota MAG had 35 different glycoside hydrolases often in multiple copies, seven extracellular CAZymes, six polysaccharide lyases, and multiple sugar transporters. This population has the potential to degrade a broad spectrum of polysaccharides including chitin, cellulose, pectin, alginate, chondroitin, and carrageenan. We also describe thermophiles affiliating with the genera Thermosyntropha, Thermovirga, and Kosmotoga with the capability to make a living on nucleic acids, lipids, or multiple macromolecule classes, respectively. Several populations seemed to lack extracellular enzyme machinery and thus likely scavenged oligo- or monomers (e.g., MAGs affiliating with Archaeoglobus) or metabolic products like hydrogen (e.g., MAGs affiliating with Thermodesulfobacterium or Desulforudaceae). The growth of methanogens or the production of methane was not observed in any condition, indicating that the tested macromolecules are not degraded into substrates for methanogenesis in hydrothermal sediments. We provide new insights into the niches, and genomes of microorganisms that actively degrade abundant necromass macromolecules under oxic, sulfate-reducing, and fermentative thermophilic conditions. These findings improve our understanding of the carbon flow across trophic levels and indicate how primary produced biomass sustains complex and productive ecosystems.
Reductive dissolution of pyrite by methanogenic archaea
Authors: Payne Devon , Spietz Rachel L , Boyd Eric S
Published: June 2021

The formation and fate of pyrite (FeS2) modulates global iron, sulfur, carbon, and oxygen biogeochemical cycles and has done so since early in Earth’s geological history. A longstanding paradigm is that FeS2 is stable at low temperature and is unavailable to microorganisms in the absence of oxygen and oxidative weathering. Here, we show that methanogens can catalyze the reductive dissolution of FeS2 at low temperature (≤38 °C) and utilize dissolution products to meet cellular iron and sulfur demands associated with the biosynthesis of simple and complex co-factors. Direct access to FeS2 is required to catalyze its reduction and/or to assimilate iron monosulfide that likely forms through coupled reductive dissolution and precipitation, consistent with close associations observed between cells and FeS2. These findings demonstrate that FeS2 is bioavailable to anaerobic methanogens and can be mobilized in low temperature anoxic environments. Given that methanogens evolved at least 3.46 Gya, these data indicate that the microbial contribution to the iron and sulfur cycles in ancient and contemporary anoxic environments may be more complex and robust than previously recognized, with impacts on the sources and sinks of iron and sulfur and other bio-essential and thiophilic elements such as nickel and cobalt.
Necroptosis protects against exacerbation of acute pancreatitis
Authors: Boonchan Michittra , Arimochi Hideki , Otsuka Kunihiro , Kobayashi Tomoko , Uehara Hisanori , Jaroonwitchawan Thiranut , Sasaki Yuki , Tsukumo Shin-ichi , Yasutomo Koji
Published: June 2021

The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of cell death and is involved in inflammatory conditions, the roles of necroptosis in acute pancreatitis (AP) remain unclear. In the current study, we administered caerulein to Ripk3- or Mlkl-deficient mice (Ripk3−/− or Mlkl−/− mice, respectively) and assessed the roles of necroptosis in AP. We found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice. Consistently, Mlkl−/− mice were more susceptible to caerulein-induced AP, which occurred in a time- and dose-dependent manner, than control mice. Mlkl−/− mice exhibit weight loss, edematous pancreatitis, necrotizing pancreatitis, and acinar cell dedifferentiation in response to tissue damage. Genetic deletion of Mlkl resulted in downregulation of the antiapoptotic genes Bclxl and Cflar in association with increases in the numbers of apoptotic cells, as detected by TUNEL assay. These findings suggest that RIPK3 and MLKL-mediated necroptosis exerts protective effects in AP and caution against the use of necroptosis inhibitors for AP treatment.
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
Authors: Wang Yu-Chen , Wang Xi , Yu Jiaji , Ma Feiyang , Li Zhe , Zhou Yang , Zeng Samuel , Ma Xiaoya , Li Yan-Ruide , Neal Adam , Huang Jie , To Angela , Clarke Nicole , Memarzadeh Sanaz , Pellegrini Matteo , Yang Lili
Published: June 2021

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment and improve cancer immunotherapy. Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain; small molecule MAO inhibitors (MAOIs) are clinically used for treating neurological disorders. Here we observe MAO-A induction in mouse and human TAMs. MAO-A-deficient mice exhibit decreased TAM immunosuppressive functions corresponding with enhanced antitumor immunity. MAOI treatment induces TAM reprogramming and suppresses tumor growth in preclinical mouse syngeneic and human xenograft tumor models. Combining MAOI and anti-PD-1 treatments results in synergistic tumor suppression. Clinical data correlation studies associate high intratumoral MAOA expression with poor patient survival in a broad range of cancers. We further demonstrate that MAO-A promotes TAM immunosuppressive polarization via upregulating oxidative stress. Together, these data identify MAO-A as a critical regulator of TAMs and support repurposing MAOIs for TAM reprogramming to improve cancer immunotherapy.
Rapid endogenic rock recycling in magmatic arcs
Authors: Li Jun-Yong , Tang Ming , Lee Cin-Ty A. , Wang Xiao-Lei , Gu Zhi-Dong , Xia Xiao-Ping , Wang Di , Du De-Hong , Li Lin-Sen
Published: June 2021

In subduction zones, materials on Earth’s surface can be transported to the deep crust or mantle, but the exact mechanisms and the nature of the recycled materials are not fully understood. Here, we report a set of migmatites from western Yangtze Block, China. These migmatites have similar bulk compositions as forearc sediments. Zircon age distributions and Hf–O isotopes indicate that the precursors of the sediments were predominantly derived from juvenile arc crust itself. Using phase equilibria modeling, we show that the sediments experienced high temperature-to-pressure ratio metamorphism and were most likely transported to deep arc crust by intracrustal thrust faults. By dating the magmatic zircon cores and overgrowth rims, we find that the entire rock cycle, from arc magmatism, to weathering at the surface, then to burial and remelting in the deep crust, took place within ~10 Myr. Our findings highlight thrust faults as an efficient recycling channel in compressional arcs and endogenic recycling as an important mechanism driving internal redistribution and differentiation of arc crust.
The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
Authors: Xu Xiaoping , Ni Kai , He Yafeng , Ren Jianke , Sun Chongkui , Liu Yie , Aladjem Mirit I. , Burkett Sandra , Finney Richard , Ding Xia , Sharan Shyam K. , Muegge Kathrin
Published: June 2021

The Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is caused by mutations in LSH/HELLS, a chromatin remodeler promoting incorporation of histone variant macroH2A. Here, we demonstrate that LSH depletion results in degradation of nascent DNA at stalled replication forks and the generation of genomic instability. The protection of stalled forks is mediated by macroH2A, whose knockdown mimics LSH depletion and whose overexpression rescues nascent DNA degradation. LSH or macroH2A deficiency leads to an impairment of RAD51 loading, a factor that prevents MRE11 and EXO1 mediated nascent DNA degradation. The defect in RAD51 loading is linked to a disbalance of BRCA1 and 53BP1 accumulation at stalled forks. This is associated with perturbed histone modifications, including abnormal H4K20 methylation that is critical for BRCA1 enrichment and 53BP1 exclusion. Altogether, our results illuminate the mechanism underlying a human syndrome and reveal a critical role of LSH mediated chromatin remodeling in genomic stability.