bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study
Authors: Luo Xin , Yin Shen , Yang Lin , Fujimoto Junya , Yang Yikun , Moran Cesar , Kalhor Neda , Weissferdt Annikka , Xie Yang , Gazdar Adi , Minna John , Wistuba Ignacio Ivan , Mao Yousheng , Xiao Guanghua
Published: May 2019

Prediction of disease prognosis is essential for improving cancer patient care. Previously, we have demonstrated the feasibility of using quantitative morphological features of tumor pathology images to predict the prognosis of lung cancer patients in a single cohort. In this study, we developed and validated a pathology image-based predictive model for the prognosis of lung adenocarcinoma (ADC) patients across multiple independent cohorts. Using quantitative pathology image analysis, we extracted morphological features from H&E stained sections of formalin fixed paraffin embedded (FFPE) tumor tissues. A prediction model for patient prognosis was developed using tumor tissue pathology images from a cohort of 91 stage I lung ADC patients from the Chinese Academy of Medical Sciences (CAMS), and validated in ADC patients from the National Lung Screening Trial (NLST), and the UT Special Program of Research Excellence (SPORE) cohort. The morphological features that are associated with patient survival in the training dataset from the CAMS cohort were used to develop a prognostic model, which was independently validated in both the NLST (n = 185) and the SPORE (n = 111) cohorts. The association between predicted risk and overall survival was significant for both the NLST (Hazard Ratio (HR) = 2.20, pv = 0.01) and the SPORE cohorts (HR = 2.15 and pv = 0.044), respectively, after adjusting for key clinical variables. Furthermore, the model also predicted the prognosis of patients with stage I ADC in both the NLST (n = 123, pv = 0.0089) and SPORE (n = 68, pv = 0.032) cohorts. The results indicate that the pathology image-based model predicts the prognosis of ADC patients across independent cohorts.
Publisher Correction: The international staging system improves the IPI risk stratification in patients with diffuse large B-cell lymphoma treated with R-CHOP
Authors: Wei Xiaolei , Hao Xiaoxiao , Zhou Lizhi , Wei Qi , Zhang Yuankun , Huang Weimin , Song Jialin , Feng Ru , Wei Yongqiang
Published: May 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Long-term evaluation of coronary artery calcifications in kidney transplanted patients: a follow up of 5 years
Authors: Alfieri C. , Forzenigo L. , Tripodi F. , Meneghini M. , Regalia A. , Cresseri D. , Messa P.
Published: May 2019

Coronary artery calcifications(CACs), are related to the increased cardiovascular mortality during kidney transplantation(KTx). Using coronary-CT performed at 1 month(T0) and 5 years(T5) after KTx we evaluated: (1) the prevalence of CACs; (2) the clinical and biochemical factors related to CACs; 3) the factors implicated with CACs progression. We evaluated 67-pts selected from the 103-pts transplanted in our unit between 2007 and 2008. Clinical and biochemical parameters were recorded at the time of pre-KTx evaluation and for five years after KTx. Coronary-CT for the Agatson score (AS) evaluation was performed at T0 and at T5, and CACs progression was determined. At baseline AS was 45 [0–233]. At T5 AS was 119 [1–413]. At T0, 69% of patients had CACs. Age and dialytic vintage were the main independent variables related to CACs. At T5, CACs were present in 76% of patients. Age was the only independent factor in determining CACs. A progression of CACs was observed in 74% of patients. They were older, had higher CACs-T0 and higher SBP throughout the 5-years. The presence of CACs at T0 and age were the only independent factors in determining the CACs-progression. CACs-T0 had the best discriminative power for CACs progression. CACs prevalence is quite high in KTx patients; Age is strictly related to CACs; Age and the presence of CACs at baseline were the two major factors associated with the progression of CACs during the five years of follow up. CACs-T0 had the best discriminative power for progression of CACs.
Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension
Authors: Ueda Yu , Johnson Lynelle R. , Ontiveros Eric S. , Visser Lance C. , Gunther-Harrington Catherine T. , Stern Joshua A.
Published: May 2019

Pulmonary hypertension (PH) is a common clinical condition associated with morbidity and mortality in both humans and dogs. Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor causing accumulation of cGMP, is frequently used for treatment of PH. The authors previously reported a PDE5A:E90K polymorphism in dogs that results in lower basal cyclic guanosine monophosphate (cGMP) concentrations than in wild-type dogs, which could contribute to variability in the efficacy of sildenafil. In this study, response to sildenafil therapy was evaluated in dogs with PH by comparing echocardiographic parameters, quality-of-life (QOL) score, and plasma cGMP concentrations before and after sildenafil therapy. Overall, tricuspid regurgitation estimated systolic pressure gradient (PG) and QOL score were significantly improved after sildenafil therapy, and the plasma cGMP concentration was significantly decreased. Dogs that had a heterozygous PDE5A status had a significantly worse QOL score when compared to the wildtype group after sildenafil treatment. The simple and multiple regression analyses revealed a significant but weak prediction for the percent reduction in QOL score with sildenafil treatment by plasma cGMP level and by the PDE5A:E90K polymorphic status. This study showed that sildenafil treatment improved PH in dogs, and the PDE5A:E90K polymorphism blunted the efficacy of sildenafil in terms of QOL improvement.
Influence of Cell Spreading Area on the Osteogenic Commitment and Phenotype Maintenance of Mesenchymal Stem Cells
Authors: Yang Yingjun , Wang Xinlong , Wang Yongtao , Hu Xiaohong , Kawazoe Naoki , Yang Yingnan , Chen Guoping
Published: May 2019

Osteogenic differentiation and commitment of mesenchymal stem cells (MSCs) is a complex process that is induced and regulated by various biological factors and biophysical cues. Although cell spreading area, as a biophysical cue, has been demonstrated to play a critical role in the regulation of osteogenic differentiation of MSCs, it is unclear how it affects the maintenance of the committed phenotype after osteogenic differentiation of MSCs. In this study, poly (vinyl alcohol) was micropatterned on a tissue culture polystyrene surface, and the micropatterns were used to culture MSCs to control their cell spreading area. The influence of cell spreading area on osteogenic differentiation and maintenance of the differentiated phenotype of MSCs was investigated. MSCs with a larger spreading area showed a higher degree of osteogenic differentiation, slower loss of differentiated phenotype and slower re-expression of stem cell markers compared with MSCs with a smaller spreading area. A large cell spreading area was beneficial for osteogenic differentiation of MSCs and maintenance of their differentiated phenotype.
Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke
Authors: Qun Sen , Hu Fuyong , Wang Guoping , Wu Juncang , Tang Qiqiang , Zhang Ji , Chen Zhengxu , Wang Xiaoqiang , Liu Qiuwan , Ge Wei
Published: May 2019

Inflammation is considered an important mechanism of cell death or survival after ischemic stroke. As an important marker of inflammation, the role of β2-microglobulin (β2M) in acute ischemic stroke is unclear. We investigated the relationship between serum β2M and the risk of acute ischemic stroke (AIS). Patients with AIS (202 cases), intracerebral hemorrhage (ICH, 41 cases), and healthy controls (253 cases) were recruited. Clinical and biochemical characteristics were collected. We used three binary logistic regression models to evaluate the correlation of β2M with the risk of AIS. Furthermore, we investigated the relationship between serum β2M and the National Institute of Health Stroke Scale (NIHSS) score, the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) subtypes, and the Essen Stroke Risk Score (ESRS) in patients with AIS. Our results showed that serum β2M levels in patients with AIS were much higher than those in patients with ICH and in the control subjects. Individuals with higher levels of β2M had higher odds of AIS. Moreover, serum β2M levels were significantly and positively correlated with ESRS. In addition, the levels of β2M were varied with different subgroups of AIS (TOAST classification). Serum β2M is highly associated with the risk of AIS.
Ultra-Clean Pure Shift 1H-NMR applied to metabolomics profiling
Authors: Lopez Juan M. , Cabrera Rodrigo , Maruenda Helena
Published: May 2019

Even though Pure Shift NMR methods have conveniently been used in the assessment of crowded spectra, they are not commonly applied to the analysis of metabolomics data. This paper exploits the recently published SAPPHIRE-PSYCHE methodology in the context of plant metabolome. We compare single pulse, PSYCHE, and SAPPHIRE-PSYCHE spectra obtained from aqueous extracts of Physalis peruviana fruits. STOCSY analysis with simplified SAPPHIRE-PSYCHE spectra of six types of Cape gooseberry was carried out and the results attained compared with classical STOCSY data. PLS coefficients analysis combined with 1D-STOCSY was performed in an effort to simplify biomarker identification. Several of the most compromised proton NMR signals associated with critical constituents of the plant mixture, such as amino acids, organic acids, and sugars, were more cleanly depicted and their inter and intra correlation better reveled by the Pure Shift methods. The simplified data allowed the identification of glutamic acid, a metabolite not observed in previous studies of Cape gooseberry due to heavy overlap of its NMR signals. Overall, the results attained indicated that Ultra-Clean Pure Shift spectra increase the performance of metabolomics data analysis such as STOCSY and multivariate coefficients analysis, and therefore represent a feasible and convenient additional tool available to metabolomics.
Structural design principles that underlie the multi-specific interactions of Gαq with dissimilar partners
Authors: Navot Shir , Kosloff Mickey
Published: May 2019

Gαq is a ubiquitous molecular switch that activates the effectors phospholipase-C-β3 (PLC-β3) and Rho guanine-nucleotide exchange factors. Gαq is inactivated by regulators of G protein signaling proteins, as well as by PLC-β3. Gαq further interacts with G protein-coupled receptor kinase 2 (GRK2), although the functional role of this interaction is debated. While X-ray structures of Gαq bound to representatives of these partners have revealed details of their interactions, the mechanistic basis for differential Gαq interactions with multiple partners (i.e., Gαq multi-specificity) has not been elucidated at the individual residue resolution. Here, we map the structural determinants of Gαq multi-specificity using structure-based energy calculations. We delineate regions that specifically interact with GTPase Activating Proteins (GAPs) and residues that exclusively contribute to effector interactions, showing that only the Gαq “Switch II” region interacts with all partners. Our analysis further suggests that Gαq-GRK2 interactions are consistent with GRK2 functioning as an effector, rather than a GAP. Our multi-specificity analysis pinpoints Gαq residues that uniquely contribute to interactions with particular partners, enabling precise manipulation of these cascades. As such, we dissect the molecular basis of Gαq function as a central signaling hub, which can be used to target Gαq-mediated signaling in therapeutic interventions.
Author Correction: Structure-Mechanical Property Relations of Skin-Core Regions of Poly(p-phenylene terephthalamide) Single Fiber
Authors: Chabi Sakineh , Dikin Dmitriy A. , Yin Jie , Percec Simona , Ren Fei
Published: May 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone
Authors: Skinner-Adams Tina S. , Fisher Gillian M. , Riches Andrew G. , Hutt Oliver E. , Jarvis Karen E. , Wilson Tony , von Itzstein Mark , Chopra Pradeep , Antonova-Koch Yevgeniya , Meister Stephan , Winzeler Elizabeth A. , Clarke Mary , Fidock David A. , Burrows Jeremy N. , Ryan John H. , Andrews Katherine T.
Published: May 2019

Atovaquone-proguanil (Malarone®) is used for malaria prophylaxis and treatment. While the cytochrome bc1-inhibitor atovaquone has potent activity, proguanil’s action is attributed to its cyclization-metabolite, cycloguanil. Evidence suggests that proguanil has limited intrinsic activity, associated with mitochondrial-function. Here we demonstrate that proguanil, and cyclization-blocked analogue tBuPG, have potent, but slow-acting, in vitro anti-plasmodial activity. Activity is folate-metabolism and isoprenoid biosynthesis-independent. In yeast dihydroorotate dehydrogenase-expressing parasites, proguanil and tBuPG slow-action remains, while bc1-inhibitor activity switches from comparatively fast to slow-acting. Like proguanil, tBuPG has activity againstP. bergheiliver-stage parasites. Both analogues act synergistically with bc1-inhibitors against blood-stages in vitro, however cycloguanil antagonizes activity. Together, these data suggest that proguanil is a potent slow-acting anti-plasmodial agent, that bc1 is essential to parasite survival independent of dihydroorotate dehydrogenase-activity, that Malarone® is a triple-drug combination that includes antagonistic partners and that a cyclization-blocked proguanil may be a superior combination partner for bc1-inhibitors in vivo.
Assessment of magnesium-based biomaterials: from bench to clinic
Authors: Razavi Mehdi , Huang Yan
Published: May 2019

This review presents the operation procedures of commonly used standard methods for assessment of Mg-based biomaterials from bench to clinic.
Aluminium(iii) dialkyl 2,6-bisimino-4R-dihydropyridinates(−1): selective synthesis, structure and controlled dimerization
Authors: Gallardo-Villagrán Manuel , Vidal Fernando , Palma Pilar , Álvarez Eleuterio , Chen Eugene Y.-X. , Cámpora Juan , Rodríguez-Delgado Antonio
Published: May 2019

2,6-Bisimino-4-alkyl-1,4-dihydropyridines provide access to dihydropyridinate(−1) aluminium(iii) dialkyls, their double cycloaddition dimerization products and metal free ditopic ligands after controlled methanolysis.
Preparation of CeSiO4 from aqueous precursors under soft hydrothermal conditions
Authors: Estevenon Paul , Welcomme Eleonore , Szenknect Stephanie , Mesbah Adel , Moisy Philippe , Poinssot Christophe , Dacheux Nicolas
Published: May 2019

Optimized conditions to form CeSiO4 (zircon type) under hydrothermal conditons were determined and allowed to propose a potential chemical mechanism.
Anthranilic amide and imidazobenzothiadiazole compounds disruptMycobacterium tuberculosismembrane potential
Authors: Smith Jake , Wescott Heather , Early Julie , Mullen Steven , Guzman Junitta , Odingo Joshua , Lamar Jason , Parish Tanya
Published: May 2019

Compounds1and2disruptM. tuberculosismembrane potential and demonstrate bactericidal activity against non-replicatingM. tuberculosisin pH 4.5 buffer.
Contrasting motif preferences of platinum and gold nanoclusters between 55 and 309 atoms
Authors: Lambie Stephanie G. , Weal Geoffrey R. , Blackmore Caroline E. , Palmer Richard E. , Garden Anna L.
Published: May 2019

Au and Pt nanoclusters show starkly different motif dominance as a function of size, as revealed by both experiment and theory.
Nanoporous gold metamaterials for high sensitivity plasmonic sensing
Authors: Garoli Denis , Calandrini Eugenio , Giovannini Giorgia , Hubarevich Aliaksandr , Caligiuri Vincenzo , De Angelis Francesco
Published: May 2019

A novel generation of portable SPR sensors with extreme sensitivity exceeding 15 000 nm per RIU is achieved with a system based on a nanoporous film.
Radio frequency heating of metallic and semiconducting single-walled carbon nanotubes
Authors: Anas Muhammad , Zhao Yang , Saed Mohammad A. , Ziegler Kirk J. , Green Micah J.
Published: May 2019

Here we report the effect of metallic (m-) and semiconducting (s-) properties of single-walled carbon nanotubes (SWCNTs) on the response of SWCNT films to radio frequency (RF) heating.
In situ growth of layered double hydroxides on boehmite AlOOH for active and stable oxygen evolution in alkaline media
Authors: He Shijie , Lin Hua
Published: May 2019

The composition with V- or Ni-doped AlOOH nanorods drives FeNi and FeCo layered double hydroxides to obtain both high activity and better stability for the oxygen evolution reaction.
Mechanism of magnetic heating in Mn-doped magnetite nanoparticles and the role of intertwined structural and magnetic properties
Authors: Del Bianco L. , Spizzo F. , Barucca G. , Ruggiero M. R. , Geninatti Crich S. , Forzan M. , Sieni E. , Sgarbossa P.
Published: May 2019

The heating efficiency of an assembly of Mn-doped magnetite nanoparticles can be tuned so as to depend linearly on the non-superparamagnetic fraction.
Photo-responsive gels based on cyclic/linear polymers: efficient synthesis and properties
Authors: Yu Jiawei , Li Kun , Li Lishan , Liu Lei , zhou Yechun , Zhang Zhengbiao , Guo Mingyu , Zhou Nianchen , Zhu Xiulin
Published: May 2019

Azobenzene-induced photoresponsive gels based on cyclic polymers were prepared and the properties of the gels formed from these cyclic polymers were investigated by comparison with gels made from the polymeric linear precursors.
NiO decorated CeO2 nanostructures as room temperature isopropanol gas sensors
Authors: Jayababu Nagabandi , Poloju Madhukar , Shruthi Julakanti , Reddy M. V. Ramana
Published: May 2019

NiO decorated CeO2 nanostructures favor enhanced sensing performance towards isopropanol even at room temperature.
Cylindrical shaped ZnO combined Cu catalysts for the hydrogenation of CO2 to methanol
Authors: Lei Hong , Zheng Ruheng , Liu Yeping , Gao Jiacheng , Chen Xiang , Feng Xiaoliang
Published: May 2019

Hydrogenation of CO2 to chemicals is of great importance in the reduction of greenhouse gas emission.
Critical behavior near room temperature in La0.75Ca0.05Na0.20MnO3 sample
Authors: Bouzidi Souhir , Gdaiem Mohamed Amara , Dhahri J. , Hlil E. K.
Published: May 2019

A set of typical M2vs. μ0H/M for La0.75Ca0.05Na0.20MnO3 sample.
Synthesis of nano-sized urchin-shaped LiFePO4 for lithium ion batteries
Authors: Yang Changjin , Lee Doo Jin , Kim Hyunhong , Kim Kangyong , Joo Jinwhan , Kim Won Bae , Song Yong Bae , Jung Yoon Seok , Park Jongnam
Published: May 2019

In this article, the facile synthesis of sea urchin-shaped LiFePO4 nanoparticles by thermal decomposition of metal-surfactant complexes and application of these nanoparticles as a cathode in lithium ion secondary batteries is demonstrated.
A circular RNAcirc_0000115in response to graphene oxide in nematodes
Authors: Shi Lifang , Jia Xiaohuan , Guo Tiantian , Cheng Lu , Han Xiaoxiao , Wu Qiuli , Wang Dayong
Published: May 2019

Circular RNAs (circRNAs) play important roles in regulating various biological processes; however, their roles in regulating the toxicity of engineered nanomaterials (ENMs) are still unclear.
Efficient resolution of 3-aryloxy-1,2-propanediols using CLEA-YCJ01 with high enantioselectivity
Authors: Wang Bin , Wu Bin , He Bingfang
Published: May 2019

CLEAs-YCJ01 had high enantioselectivity to a series of 3-aryloxy-1,2-propanediols with high conversion (≥49.3%), favorable ee values (94.8–99.5%) for S-diacetates and high ee values (92.1–99.2%) for R-monoacetate.
Rosette-like MoS2 nanoflowers as highly active and stable electrodes for hydrogen evolution reactions and supercapacitors
Authors: Liu Xuexia , Liu Limin , Wu Ying , Wang Yinfeng , Yang Jinhu , Wang Zhijun
Published: May 2019

A simple strategy to synthesize interlayer spacing-enlarged rosette-like MoS2 nanoflowers for both the hydrogen evolution reaction and supercapacitive energy storage.
Lanthanide complexes combined with chiral salen ligands: application in the enantioselective epoxidation reaction of α,β-unsaturated ketones
Authors: Xia Xuexiu , Lu Chengrong , Zhao Bei , Yao Yingming
Published: May 2019

The enantioselective epoxidation of α,β-unsaturated ketones was catalysed by readily available lanthanide amides La[N(SiMe3)2]3 combined with chiral salen ligands.
Thermodynamic, structural and dynamic properties of ionic liquids [C4mim][CF3COO], [C4mim][Br] in the condensed phase, using molecular simulations
Authors: Sánchez-Badillo Joel , Gallo Marco , Guirado-López Ricardo A. , López-Lemus Jorge
Published: May 2019

Non-covalent interactions, coordination numbers, RDFs, SDFs, CDFs, and transport properties for the [C4mim][Br] and [C4mim][CF3COO] ionic liquids were determined.
Switchable conformational changes of DNA nanogel shells containing disulfide–DNA hybrids for controlled drug release and efficient anticancer action
Authors: Liwinska Wioletta , Stanislawska Iwona , Lyp Marek , Stojek Zbigniew , Zabost Ewelina
Published: May 2019

Switchable conformational changes of multiresponsive nanogels containing disulfide/DNA hybrid shells for pulsative drug release.
Acid-durable electride with layered ruthenium for ammonia synthesis: boosting the activity via selective etching
Authors: Li Jiang , Wu Jiazhen , Wang Haiyun , Lu Yangfan , Ye Tiannan , Sasase Masato , Wu Xiaojun , Kitano Masaaki , Inoshita Takeshi , Hosono Hideo
Published: May 2019

We reported LnRuSi as a B5-site-free Ru catalyst for ammonia synthesis, and its activity enhanced 2–4-fold by selective etching with EDTA-2Na.
In situ growth of α-CsPbI3 perovskite nanocrystals on the surface of reduced graphene oxide with enhanced stability and carrier transport quality
Authors: Zhang Qi , Nan Hui , Zhou Yangying , Gu Youchen , Tai Meiqian , Wei Yaxuan , Hao Feng , Li Jianbao , Oron Dan , Lin Hong
Published: May 2019

An in situ solution growth method to prepare preferentially assembled and well-distributed α-CsPbI3 nanocrystals/reduced graphene oxide heterostructures is presented.
Cognitive Load Affects Speech Motor Performance Differently in Older and Younger Adults
Authors: MacPherson Megan K.
Published: May 2019

Purpose

The aim of this study was to determine the impact of cognitive load imposed by a speech production task on the speech motor performance of healthy older and younger adults. Response inhibition, selective attention, and working memory were the primary cognitive processes of interest.

Method

Twelve healthy older and 12 healthy younger adults produced multiple repetitions of 4 sentences containing an embedded Stroop task in 2 cognitive load conditions: congruent and incongruent. The incongruent condition, which required participants to suppress orthographic information to say the font colors in which color words were written, represented an increase in cognitive load relative to the congruent condition in which word text and font color matched. Kinematic measures of articulatory coordination variability and movement duration as well as a behavioral measure of sentence production accuracy were compared between groups and conditions and across 3 sentence segments (pre-, during-, and post-Stroop).

Results

Increased cognitive load in the incongruent condition was associated with increased articulatory coordination variability and movement duration, compared to the congruent Stroop condition, for both age groups. Overall, the effect of increased cognitive load was greater for older adults than younger adults and was greatest in the portion of the sentence in which cognitive load was manipulated (during-Stroop), followed by the pre-Stroop segment. Sentence production accuracy was reduced for older adults in the incongruent condition.

Conclusions

Increased cognitive load involving response inhibition, selective attention, and working memory processes within a speech production task disrupted both the stability and timing with which speech was produced by both age groups. Older adults' speech motor performance may have been more affected due to age-related changes in cognitive and motoric functions that result in altered motor cognition.
Programmable metasurface applied to antenna measurement
Authors: Zhang Liang , Wang Tianting , Wang Fei , Liu Yang , Wu Xianliang
Published: May 2019

The authors propose a novel method for significantly reducing antenna measurement time and increasing the efficiency of collecting the data which most is relevant information. They apply methods from compressed sensing which reduce redundancy in the antenna measurement, i.e. a metasurface is added to the antenna near‐field, and the unit cell is manipulated by a FPGA to facilitate sparse sampling. In comparison with the traditional sparse sampling method, experimental results demonstrate that their strategy can reduce the measuring time by at least 56% while satisfying measurement error and that it has considerable potential for antenna measurement.
Flexible, reliable, and renewable power system resource expansion planning considering energy storage systems and demand response programs
Authors: Hamidpour Hamidreza , Aghaei Jamshid , Pirouzi Sasan , Dehghan Shahab , Niknam Taher
Published: May 2019

This study presents a flexible, reliable, and renewable power system resource planning approach to coordinate generation, transmission, and energy storage (ES) expansion planning in the presence of demand response (DR). The flexibility and reliability of the optimal resource expansion planning are ensured by means of appropriate constraints incorporated into the proposed planning tool where thermal generation units, ES systems, and DR programs are considered as flexibility resources. The proposed planning tool is a mixed‐integer non‐linear programming (MINLP) problem due to the non‐linear and non‐convex constraints of AC power flow equations. Accordingly, to linearise the proposed MINLP problem, the AC nodal power balance constraints are linearised by means of the first‐order expansion of Taylor's series and the line flow equations are linearised by means of a polygon. Additionally, the stochastic programming is used to characterise the uncertainty of loads, a maximum available power of wind farms, forecasted energy price, and availability/unavailability of generation units and transmission lines by means of a sufficient number of scenarios. The proposed planning tool is implemented on the IEEE 6‐bus and the IEEE 30‐bus test systems under different conditions. Case studies illustrate the effectiveness of the proposed approach based on both flexibility and reliability criteria.
Galactic cosmic ray hydrogen spectra and radial gradients in the inner heliosphere measured by the HELIOS Experiment 6
Authors: Marquardt J. , Heber B.
Published: May 2019

Context. The HELIOS solar observation probes provide unique data regarding their orbit and operation time. One of the onboard instruments, the Experiment 6 (E6), is capable of measuring ions from 4 to several hundred MeV nucleon−1.

Aims. In this paper we aim to demonstrate the relevance of the E6 data for the calculation of galactic cosmic ray (GCR), anomalous cosmic ray (ACR), and solar energetic particle (SEP) fluxes for different distances from the sun and time periods.

Methods. Several corrections have been applied to the raw data: determination of the Quenching factor of the scintillator, correction of the temperature dependent electronics, degradation of the scintillator as well as the effects on the edge of semi-conductor detectors.

Results. Fluxes measured by the E6 are in accordance with the force field solution for the GCR and match models of the anomalous cosmic ray propagation. GCR radial gradients in the inner heliosphere show a different behaviour than in the outer heliosphere.
À quoi « adhère » son épaule ?
Authors: Hongqiu Xiao
Published: May 2019

La psychanalyste Xiao Hongqiu exerçait à Chengdu (cf. note 2). Elle fit partie du groupe des praticiens réunis autour de l’enseignement de Huo Datong. Son texte est riche d’enseignement sur la façon dont l’écriture et le langage tiennent le corps. La patiente Madame A soufre de douleurs articulaires, très vite des moments de dépression apparaissent et la période de l’adolescence est explorée avec soin. Si cette femme évoque la célèbre Anna O. de Breuer et Freud, ce texte laisse place à une série de remarques concernant l’évoluution des places et des rôles des femmes dans la Chine contemporaine. L’auteure est aussi concernée par la façon dont l’écriture chinois fait place au corps.
Les diagonales de #MeToo
Authors: Dominique Garnier Marie , Benveniste Annie , Sélim Monique
Published: May 2019

Ce dossier présente trois réactions féministes et non-« universalistes » à l’ampleur mondiale du mouvement #MeToo. En contexte francophone, des voix critiques se sont fait entendre au nom d’une « liberté » républicaine, voix rassemblées sous le label de la « rubrique Deneuve ». Si un certain nombre de prises de paroles ont pu légitimement avoir lieu contre ce qu’il est convenu d’appeler la « domination masculine », il n’est pas certain cependant que, comme l’analyse Laure Murat dans Une Révolution sexuelle ? (2018) se soit écrit dans cette prise de parole « le prologue d’un livre qui commence ». Il n’est pas davantage certain que l’après-Weinstein soit l’occasion, comme elle l’écrit avec optimisme, de « réparer le contrat social ». Comment un contrat social peut-il être établi dès lors qu’une partie du « social » s’articule à ce que Deleuze et Guattari ont analysé comme un ensemble de « groupes assujettis » (par opposition à des groupes-sujets, c’est-à-dire des ensembles non identitaires, par exemple non assujettis à une identité de genre) ? Et comment penser les interstices d’un nouveau féminisme sans continuer à croire au concept binarisant de « domination », que les analyses de Michel Foucault ont revisité de façon convaincante pour lui substituer un tout autre niveau d’analyses, à savoir celui d’une microphysique du pouvoir ? Comment repenser le corps social dessiné par un « après #MeToo » en lui inventant un contre-discours qui ne se laisse pas prendre au piège de notions et de catégories oppositionnelles simplistes ?

Les trois lectures présentées ici émanent de champs disciplinaires différents.

Dans une perspective féministe non binaire qui décrypte les différences majeures entre les mobilisations post-1968 et les luttes présentes, Marie-Dominique Garnier interroge la notion désormais centrale de consentement dans la pensée française, Annie Benveniste revient sur la médiatisation en France de #MeToo un an après, et Monique Selim dévoile les enchaînements sémantiques et conceptuels qui travaillent au succès de #MeToo.
Bildgebende Diagnostik bei Rechtsherzerkrankungen
Authors: Hammerstingl Christoph , Bernhardt Peter
Published: May 2019

Erkrankungen des rechten Herzens wurden über viele Jahre hinweg nicht als prognostisch relevant erachtet. Die Erkenntnis über den progressiven Verlauf unterschiedlicher Pathologien mit einem direkten Einfluss auf das Outcome der betroffenen Patienten rückt moderne, teils experimentelle Therapieverfahren aktuell zunehmend in den Fokus der medizinischen Aufmerksamkeit. Basis für die Entwicklung neuer therapeutischer Ansätze ist ein grundlegendes Verständnis und die adäquate Darstellung der Anatomie des rechten Herzens und der komplexen Zusammenhänge mit der pulmonalen Hämodynamik. Unterschiedliche bildgebende Verfahren werden bereits eingesetzt für die Beurteilung der Anatomie und pathologischer Veränderungen des rechten Herzens.
Risikoscreening im Leistungsfußball am Beispiel einer
Nachwuchsmannschaft
Authors: Suslik Dominik
Published: May 2019

Bei der Frage, wie sich das Verletzungsrisiko von Sportlern reduzieren lässt,
hilft die Suche nach relevanten Risikofaktoren. Auch das Anforderungsprofil der
Sportart und die Prävalenzen von Verletzungen sollte man kennen. Auf dieser
Grundlage hat das medizinische Betreuerteam von Hannover 96 ein
Screeningverfahren für die eigenen Jugendmannschaften entwickelt, mit dem
Schwachstellen gezielt aufgedeckt werden können.
Befund erheben und Ziele finden – Professionelles Reasoning in der Pädiatrie – Teil 1
Authors: Strebel Helen , Zillhardt Cornelie
Published: May 2019

Die Ergotherapie hat sich in den letzten 20 Jahren sehr verändert. Während dieser Zeit entstand unter anderem das professionelle Reasoning, das Ergotherapeuten in ihrem klinischen Entscheidungsprozess unterstützt. Helen Strebel und Cornelie Zillhardt durchlaufen Befunderhebung und Zielfindung anhand eines Fallbeispiels aus heutiger Sicht und aus der Sicht von vor 20 Jahren.
Influence of video-based feedback on self-assessment accuracy of endoscopic skills: a randomized controlled trial
Authors: Scaffidi Michael , Walsh Catharine , Khan Rishad , Parker Colleen , Al-Mazroui Ahmed , Abunassar Michael , Grindal Alexander , Lin Peter , Wang Christopher , Bechara Robert , Grover Samir
Published: May 2019

Background and study aims Novice endoscopists are inaccurate in self-assessment of procedures. One means of improving self-assessment accuracy is through video-based feedback. We aimed to determine the comparative effectiveness of three video-based interventions on novice endoscopists’ self-assessment accuracy of endoscopic competence.

Materials and methods Novice endoscopists (performed < 20 previous procedures) were recruited. Participants completed a simulated esophagogastroduodenoscopy (EGD) on a virtual reality simulator. They were then randomized to one of three groups: self-video review (SVR), which involved watching a recorded video of their own performance; benchmark review (BVR), which involved watching a video of a simulated EGD completed by an expert; and self- and benchmark video (SBVR), which involved both videos. Participants then completed two additional simulated EGD cases. Self-assessments were conducted immediately after the first procedure, after the video intervention and after the additional two procedures. External assessments were conducted by two experienced endoscopists, who were blinded to participant identity and group assignment through video recordings. External and self-assessments were completed using the global rating scale component of the Gastrointestinal Endoscopy Competency Assessment Tool (GiECAT GRS).

Results Fifty-one participants completed the study. The BVR group had significantly improved self-assessment accuracy in the short-term, compared to the SBVR group (P = .005). The SBVR group demonstrated significantly improved self-assessment accuracy over time (P = .016). There were no significant effects of group or of time for the SVR group.

Conclusions Video-based interventions, particularly combined use of self- and benchmark video review, can improve accuracy of self-assessment of endoscopic competence among novices.
Der infarktbedingte kardiogene Schock
Authors: Dörr Oliver , Hamm Christian , Nef Holger M.
Published: May 2019

Die Prognose der Patienten im kardiogenen Schock kann durch eine frühzeitige invasive Diagnostik und rasche Myokardrevaskularisation verbessert werden. Hierbei hat sich die PCI der Culprit-Lesion gegenüber der kompletten Revaskularisation in der Akutphase als überlegen gezeigt. Durch mechanische Unterstützungssysteme konnte eine Prognoseverbesserung erzielt werden, deren Vorteil allerdings durch weitere prospektive Studien validiert werden muss.
Falsche Ärzte ohne Ende
Authors: Hardinghaus Christian
Published: May 2019

Chirurg, Psychiater, Palliativmediziner. Es gibt kein medizinisches Fachgebiet, das frei ist von Betrügern in weißem Kittel. Erfolgreich läuft gerade die True-Crime Serie Dirty John über die wahre Geschichte von John Meehan. Der schwer drogenabhängige Anästhesie-Pfleger nutzte seinen Job nicht nur aus, um frisch operierten Patienten in verschiedenen Krankenhäusern der USA die Medikamente zu stehlen, sondern gab sich privat als Arzt aus, um an Herz und Geld reicher Frauen zu kommen.

Der Beruf des Arztes scheint prädestiniert dafür zu sein, von Betrügern ausgenutzt zu werden. Die Gründe dafür sind vielfältig. So wollen etwa gescheiterte Medizinstudenten ihren Berufswunsch nicht aufgeben. Dafür fälschen sie Urkunden und arbeiten ohne Abschluss und Zulassung. Aber auch Fachfremde haben Patienten operiert. Das medizinische Wissen eignen sie sich dafür zum Beispiel über Youtube-Videos an. Den meisten geht es darum, viel Geld zu verdienen. Aber auch Prestige spielt eine Rolle. Falsche Ärzte suchen nach gesellschaftlicher Anerkennung und Status. Einige spektakuläre Fälle aus Deutschland stelle ich Ihnen im Folgenden vor.
Self-organization of neutral particles on the surface of superfluid He II
Authors: Levchenko A. A. , Lebedeva E. V. , Mezhov-Deglin L. P. , Pelmenev A. A.
Published: May 2019

To visualize the vortex flows occurring on the surface of superfluid He II during the interaction of noncollinear surface waves, hollow glass microspheres ∼60 μm in diameter and a density less than or similar to that of liquid helium were introduced into the liquid. The spheres combined under the He II surface into aggregates (tracers) with characteristic dimensions of 0.2–0.3 mm. Experimental results are presented, and the possibility of helium-covered light tracers self-organizing and using surface tension to form experimentally observable flat macroscopic “snowflake” structures out of glass tracers on the He II surface, is discussed.
Percolation transitions in d-wave superconductor–half-metallic ferromagnet nanocomposites
Authors: Krivoruchko V. N. , Tarenkov V. Yu.
Published: May 2019

Electrical transport properties of random binary networks composed of high-Tc superconductor Bi2Sr2Ca2Cu3O6+x microparticles and half-metallic ferromagnet La0.67Sr0.33MnO3 (LSMO) nanoparticles have been investigated. Two resistive percolation transitions (superconductor–metal–semiconductor) have been observed for the nanocomposites with a volume fraction of the LSMO no more than 30%. The nanocomposites basic attributes (transition critical temperatures, current–voltage characteristics, percolation threshold, etc.), most probably, cannot be quantitatively interpreted within the framework of a conventional percolation model. We have explained the observed behavior by a two-level scale interaction in the system caused by (i) a significant geometric disparity between the constituent components and (ii) proximity-induced superconducting state of the half-metallic manganite.
Dislocation mechanisms of low-temperature acoustic relaxation in iron
Authors: Natsik V. D. , Semerenko Yu. A.
Published: May 2019

An integrated approach to the study of the mechanisms of low-temperature dislocation relaxation during low-temperature cyclic deformations of crystalline materials has been developed and tested. The approach is based on the combined use of experimental methods of mechanical spectroscopy in wide frequency-temperature ranges and theoretical methods of statistical and thermoactivation analysis of experimental results. The efficiency of this approach was demonstrated by studying low-temperature relaxation resonances in iron crystals whose dislocation structure was varied by preliminary plastic deformation. In this study, the previous mechanical spectroscopy results for iron in the temperature range of 4 K < T < 150 K at vibrational frequencies of about 1 Hz and 105 Hz were supplemented by a detailed study of the temperature spectra of internal friction and the Young’s modulus of a single-crystal iron plate at intermediate frequencies of about 103 Hz. A two-mode dislocation relaxator model was suggested for interpreting the entire set of experimental results. Its first component is a linear segment of a dislocation line in a first-kind Peierls relief whose relaxation properties are determined by thermal activation of kink pairs. The second component is a chain of geometric kinks capable of thermally activated diffusion movement in a second-kind Peierls relief. Empirical estimates of the energy, force, inertial, and geometric characteristics of both components of such a relaxator have been obtained. This study complements the earlier analysis of the processes of mechanical relaxation in crystals caused by nucleation and movements of kinks on dislocation lines [a review: A. Seeger and C. Wüthrich, Nuovo Cimento B 33, 38 (1976)].
Fuzzy expert system for management of smart hybrid energy microgrid
Authors: Žarković Mileta , Dobrić Goran
Published: May 2019

This paper proposes a fuzzy expert system for demand-side management, management of renewable energy sources, and electrical energy storage for smart households and microgrids. The proposed fuzzy expert system is used for automatic decision making regarding energy management in smart microgrids containing renewable sources, storage systems, and controllable loads. The fuzzy expert system optimizes energy consumption and storage in order to utilize renewable energy and maximize the financial gain of a microgrid. In order to enable energy management, the fuzzy expert system uses insolation, price of electrical energy, temperature, wind speed, and power of the controllable and uncontrollable loads as input variables. These input data can be directly measured, imported from grid measurements, or predicted using any data prediction method. This paper presents fuzzification of input variables, defines a set of rules of the expert system, and presents defuzzification of outputs. The outputs of the expert system are decisions, i.e., answers to the question of how to manage energy production and consumption in a microgrid. Three outputs are defined to decide about produced energy, controllable loads, and own consumption. The first output is used to store, sell, or consume produced energy. The second output is used to manage the controllable load. The third output shows how to supply own consumption of the prosumer. The expert system is tested on hourly values of input variables in a single day in Serbia. The proposed approach is compared with other available approaches in order to validate the results.
Genetic structure of the endangered, relict shrub Amygdalus mongolica (Rosaceae) in arid northwest China
Authors: Ma Song Mei , Nie Ying Bin , Jiang Xiao Long , Xu Zhe , Ji Wan Quan
Published: May 2019

In the present study we selected the endangered species Amygdalus mongolica to investigate the influence of climatic fluctuations on the spatial genetic patterns and evolutionary history of organisms in arid northwest China. The intraspecific genetic variation and demographic history of A. mongolica were investigated using two cpDNA sequences (psbK-psbI and trnL-trnF) from 174 individuals in 15 populations across most of its covered range. Significant genetic differentiation among populations was identified, which resulted from fragmented populations coupled with the enhanced aridification and desertification of the Pleistocene. Twelve haplotypes clustered into two clades, corresponding to the Western region (northernmost Gansu, Hexi Corridor and Alxa Left Banner) and the Eastern region (Urad Houqi, Yinshan Mountains, Urad Zhongqi and Daqing Mountains) respectively. Five independent Pleistocene refugia in different mountainous areas were identified. Amygdalus mongolica has likely experienced westward shifts from refugia along the margins of the Ulanbuhe and Tengger deserts, and also postglacial re-colonisation northward along the Hexi Corridor.
Fundamental parenchyma cells are involved in Na+ and Cl– removal ability in rice leaf sheath
Authors: Neang Sarin , de Ocampo Marjorie , Egdane James A. , Platten John D. , Ismail Abdelbagi M. , Skoulding Nicola S. , Kano-Nakata Mana , Yamauchi Akira , Mitsuya Shiro
Published: May 2019

Salt sensitivity in rice plants is associated with the accumulated amount of Na+ and Cl– in shoots and, more significantly, in photosynthetic tissues. Therefore, salt removal ability at the leaf sheath level is an important mechanism of salt tolerance. In the present study we attempted to determine whether rice leaf sheaths excluded Cl– as well as Na+, and to identify the tissues that were involved in the removal ability of both ions. In two rice genotypes, salt-tolerant FL478 and -sensitive IR29, leaf sheaths excluded Na+ and Cl– under NaCl treatment as estimated using their sheath:blade ratios. The sheath:blade ratio of Na+ but not of Cl–, was increased by NaCl treatment. Under NaCl treatment, Na+ concentration was higher in the basal leaf sheath, whereas Cl– concentration was higher in the middle and tip parts. At the tissue level, fundamental parenchyma cells of leaf sheaths retained the highest amounts of Na and Cl when treated with high amount of NaCl. These results imply that the leaf sheath potentially functions to remove excess Na+ and Cl– from xylem vessels in different locations along the axis, with the fundamental parenchyma cells of leaf sheaths being involved in over-accumulation of both Na+ and Cl–.
Bird community responses to changes in vegetation caused by increasing large mammal populations in the Serengeti woodlands
Authors: Nkwabi Ally K. , Metzger Kris , Beyers Rene , Magige Flora , Mduma Simon A. R. , Hopcraft J. Grant C. , Sinclair Anthony R. E.
Published: May 2019

Context
The increase in density of large tree species, Vachellia robusta and V. tortilis, in the Serengeti Ecosystem of Tanzania has resulted in a decline of small tree species Senegalia senegal, V. hockii, Commiphora spp. This change has occurred since the late 1970s, a consequence of an increase in wildebeest following the extirpation of rinderpest, which reduced the dry grass fuel for fires, resulting in low fire frequencies. Change in tree species raises the question of whether there are indirect consequences for the avifauna that depend on the large trees for food and nesting.

Aims
To determine how an increase in large mammals could influence diversity and distribution of avifauna communities in the Serengeti ecosystem woodlands.

Methods
Data used to estimate changes in density of large and small trees were measured by Point Centre Quarter (PCQ). Bird species were recorded in 19 small-tree sites and 18 large-tree sites in the Serengeti National Park. Richness of bird guilds was calculated in the two habitat complexes (small and large trees), and the ‘rarefaction’ method was used to assess the difference in richness in habitats of the study area. Mean abundance for each species was calculated over the total number of sites for each habitat and compared using the Wilcoxon Rank Sum test to examine how the abundance of avifauna changes with each habitat type.

Key results
There was an increase in the density of large trees in some areas in which they have replaced the original small trees. Such changes have resulted in greater richness of hole nesters and bark feeders, and a greater abundance of large-hole nesters and gleaner bird species.

Conclusions
Because the increase in tree density was caused by an increase in large mammals, we conclude that this increasing mammal population is indirectly increasing richness and abundance of birds using the trees.

Implications
Understanding the influence of large mammal populations on bird distributions has important conservation implications because the Serengeti ecosystem is classified as an important, endemic bird area.