bluuebunny/crossref_metadata_2025 huggingface dataset:
siRNA Mediated Gene Silencing in the Pancreatic Cancer Capan-1 Cell Line
Authors: BUDAK YILDIRAN Azize
Published: December 2022

Today, pancreatic cancer ranks second after the cardiovascular system among the causes of death. The pancreatic cancer which is an aggressive type progressing without giving too many symptoms. In addition, factors such as difficulty in early diagnosis, rapid metastasis and non-response to traditional treatments cause a low survival rate in this type of cancer. Therefore, many studies are carried out to develop alternative diagnosis and treatment methods. Focus is put on target-oriented studies to increase the survival rate and eliminate other negative effects. The gene therapy method is at the forefront of such studies. RNA interference (RNAi) molecules are crucial in this method. From among these molecules, small non-coding RNA (siRNA) are used in studies as a therapeutic agent by its delivery to the target gene by various mechanisms. Studies are carried out with different biological and chemical agents to deliver the molecules to the target cell efficiently.

This study aimed to silence the c-Myc gene using gold nanoparticle (AuNP)-siRNA in the Capan-1 cell line. We performed Real-Time PCR, Dual Staining and gel electrophoresis using gold nanoparticles (2X, 4X, 8X) and siRNA (25 nM) at concentrations determined in the Capan-1 cell line. The data obtained from the analysis suggested that the nanoparticle siRNA complex could be used effectively in silencing the target gene. Nevertheless, effective results could be obtained with more knowledge on this subject.
Synthesis and Characterization of MoSi2 Particle Reinforced AlCuMg Composites by Molten Salt Shielded Method
Authors: AKKAŞ Mehmet
Published: December 2022

AlCuMg and its alloys are the most preferred composite materials in areas such as automotive, aerospace and aerospace industries due to their positive properties such as high corrosive properties, heat resistance, high strength and toughness. However, the inadequacy of these alloys in terms of wear and mechanical properties is one of the problems encountered in the industry. As a result of the literature review, it has been determined that there are almost no studies to improve the mechanical properties of these alloys. In this study, MoSi2 particles in different percentages were added to AlCuMg matrix and produced by powder metallurgy method. The aim is to improve the mechanical properties of AlCuMg matrix composite material and to perform characterization processes. Molten salt shielded synthesis/sintering process was used as a protective atmosphere environment for the produced samples to protect them from oxidation during sintering. In salt-protected synthesis, potassium bromide (KBr) was preferred as the salt. After the synthesis process, Scanning Electron Microscope (SEM), Energy Dispersion Spectroscopy (EDS), X-Ray Diffractometry (XRD) analyzes were applied respectively as characterization processes. In addition, microhardness test was performed to determine the mechanical properties of the produced composites. It has been determined that MoSi2 particles reinforced to AlCuMg alloy increase the mechanical properties of AlCuMg composite material because they have high values ​​in terms of hardness and melting temperature.
Assessment of The Use of Artemisia Dracunculus L and Erigeron Canadensis in The Remediation of Heavy Metal Contaminated Soils and Their Ability to Phytoextraction and Biomass Yield.
Authors: KOCAMAN Ayhan
Published: December 2022

Different hyperaccumulator plants growing in the same contaminated soil may have excessive accumulation of different metals or produce biomass. Therefore, it is important to determine the ability of the plant to improve the soil under natural conditions in the improvement of heavy metal-contaminated lands with hyperaccumulator plants. This study focused on the phytoremediation and biomass production capabilities of Artemisa Dracunculus L. and Erigeron Canadensis plants. Considering this fact, Erigeron Canadensis was determined to have the highest phytoextraction potential between the two plants, as it produces more biomass (96%) and mineral content (169%) than Artemisa Dracunculus L. This shows that Erigeron Canadensis has more phytoremediation potential than Artemisa Dracunculus L. and that Erigeron Canadensis plant is one of the alternative hyperaccumulator plant candidates and is more effective for soil reclamation. In addition, when the plants were categorized according to their BAF values, accumulator (1
The Use of Macerated Garlic (Allium Sativum L.) Oil in Preventing the Postoperative Adhesions in Rats
Authors: ÇALIŞKAN G. Ülke , EMİN Nuray
Published: December 2022

In the present study, the efficiency of intra-abdominal use of the macerated oil obtained from Taşköprü Garlic (Kastamonu/Türkiye), which is one of the products with geographical indication-from European Union, in preventing the postoperative adhesions. The chemical structure of the macerated-oil, prepared using fresh-garlic at a concentration of 1.2 g/ml in olive oil, was analyzed by spectrophotometric and chromatographic methods. In in vivo experiments, Wistar Albino rats (n=8) were applied cecal abrasion under general anesthesia. Abrasion zone was treated with physiological saline solution in control group (K) and different doses of macerated oil (0.5-1 ml) in study groups-(S1 S2). Macroscopic-adhesion-scoring-(MAS) between 0-4 was performed for all the subjects on postoperative days 3-28. After staining the tissue-samples, which were taken from subjects found to have adhesion, histopathological adhesion scoring (HAS) was performed between 0 3. On day 3, adhesion was detected in all the subjects. The adhesions reached MAS-2 level in the K and were in MAS 1 level in the subjects in S1 S2. On day 28, no adhesion was observed in S1-S2, whereas adhesions in K remained at the level MAS-2. Moreover, HAS were found to be HAS-1 in S1 S2-K on day 3 whereas it was found to be HAS-2 in K subjects, where adhesion formation continued, on day 28. As a result, the garlic-macerated-oil, obtained by soaking fresh garlic in olive oil for a time, is a low cost and effective agent for adhesion prevention, which will be easily produced and applied by clinicians.
Wound Healing of Quinic Acid in Human Dermal Fibroblasts by Regulating Expression of FN1 and COL1A1 Gene
Authors: GENÇ Sıdıka , YENİ Yeşim , ÇİÇEK Betül , HACIMÜFTÜOĞLU Ahmet
Published: December 2022

Quinic acid (QA) is an alicyclic organic acid widely found in plants. It accumulates in varying concentrations of plant species and is actively metabolized throughout the plant's life cycle. Wound healing after skin injury involves a complex interaction of many cells, fibroblasts, endothelial cells, and regenerated immune cells and their interrelating extracellular matrix. In our study, the healing effect of QA on scar tissue was studied. For this aim, oxidative stress, and changes in FN1 and Collogen1α gene levels were examined. For this purpose, fibroblast cells were seeded in 24, 96 and well plates for wound healing, MTT analysis and Real-Time PCR testing (respectively). Wells were drawn with a 100 µL pipette tip for wound line. As a conclusion of our study, it was determined that cell viability increased significantly, especially in the QA 20 µg-ml group at the end of 48 hours. Increased cell viability and antioxidant capacity resulted in increased cell proliferation. Both FN1 and COL1A1 gene expression levels were up regulated in the QA groups compared to the control group. Our findings show for the first time that quinic acid promotes migration and/or proliferation of fibroblasts by regulating oxidative stress and the FN1A and COL1A1 genes. This activity may be related to the production of FN1A and COL1A1, which are considered important targets for modulation of the tissue repair process.
Mario Vitorino
Authors: Simões Marcio
Published: December 2022

O período patrístico foi de grande importância não apenas para a defesa do Cristianismo, mas também para seu robustecimento. O quarto século talvez possa ser considerado como responsável pelo início da estruturação da expansão da Igreja e de sua consolidação doutrinária-dogmática. Tendo por alvo a definição do que se vivia ou compreendia no âmbito da fé, muitos filósofos, pensadores, e teólogos se arriscavam nesta seara. Neste sentido, este artigo tem por objeto explorar as informações biográficas de Mario Vitorino (Victorinus Afer), evidenciar suas contribuições em temas muito caros à história da Igreja e abordar reflexões dogmáticas que se fizeram presentes ou que tiveram seu ápice nas discussões dos dois primeiros concílios ecumênicos. Ex-pagão, mesmo que protagonista de um caminho de conversão em um período que o Cristianismo se vê reconhecido como religião oficial e não mais marginal, seu ímpeto apologético foi o sinal mais marcante de sua trajetória, sobretudo na discussão em busca da definição da consubstancialidade entre Cristo e o Pai.
A importância da Festa da Páscoa nos relatos da última ceia
Authors: Carvalho Moraes Arthur
Published: December 2022

Este artigo tem como objetivo mostrar como a páscoa cristã foi elaborada e concebida pelos primeiros cristãos dentro do horizonte semântico e de significações da Páscoa Judaica. Ao fazer coincidir a ceia de despedida de Jesus com a noite da Festa da Páscoa, os Sinóticos apresentam a última ceia como um memorial definitivo da ação salvífica de Jesus operada na cruz (Mt 26,26-29; Mc 14,22-25; Lc 22,15-20; 1Cor 11,23-26), tal como a Pessach judaica é memorial da ação libertadora de Deus em favor do povo escolhido (Ex 12,1-28). Por outro lado, o Evangelho de João, ao apresentar a morte de Jesus ocorrendo em dia anterior à Páscoa, almeja identificar o sacrifício de Jesus com o sacrifício do Cordeiro Pascal (Jo 1,36; 1Cor 5,7), imolados na mesma hora e dos quais não se quebram os ossos, de modo que todo o mistério salvífico de Jesus Cristo seja inscrito em linhas pascais. Com diferentes matizes teológicas, os Evangelhos tomam, portanto, das categorias pascais os significados mais fortes para interpretar a oblação salvífica de Jesus, de modo que só se entende todo o alcance teológico da morte e ressurreição de Cristo se inscrevê-las como um “mistério pascal”.
Teologia da Missão nos discursos de Bento XVI
Authors: Dos Santos Rosa Luiz Gustavo
Published: December 2022

Este artigo tem como objetivo observar o pontificado de Bento XVI e analisar em seus discursos pontos que evidenciam a Teologia da Missão, também chamada de Missiologia. Tendo como base suas falas durante o Dia Mundial das Missões e aliando a documentos oficiais da Igreja, propõe-se extrair o que Joseph Ratzinger pensava sobre a Missão – suas ideias, cautelas, anseios e inspirações. A Missão é a principal atividade da Igreja e o seuverdadeiro objetivo. O anúncio do Evangelho deve ser o que motiva e inspira todo o Povo de Deus para que a mensagem chegue a todos. Nesse engendramento, valem algumas reflexões que ajudam a entender como a missão pode ser feita de maneira eficaz, sem perder o foco ou desvirtuar do seu real motivo, fazendo com que o Reino de Deus seja estabelecido. O ânimo em anunciar a Palavra, o compromisso assumido por todas as partes do “corpo” deCristo, a universalização da mensagem e unidade dos cristãos em prol da evangelização, o aspecto social que a missão empenha, o papel de Maria dentro da Missão e a caridade são os temas destaques que despontam nos discursos do papa emérito e esse artigo trabalhará cuidadosamente.
Supergénna mineralizácia na II. horizonte Východnej šachty hnedouhoľnej bane Handlová (Slovenská republika)
Authors: Myšľan Pavol , Števko Martin , Ivan Karsten
Published: December 2022

At the II. horizon of the Eastern shaft of Handlová coal mine the occurrence of mineral assemblage of secondary minerals was identified. These accumulations consist of sulphate group minerals confirmed by PXRD and semiquantitative chemical analysis (EDS), namely gypsum, alunogen, pickeringite, melanterite, sideronatrite and epsomite. Sulphates form coatings, crystalline crusts and aggregates, which crystallized on the walls of mine corridors. The dimensions of these accumulations are reaching approximately 1.5 x 1.3 m with thickness up to 5 cm. The refined unit-cell parameters of alunogen (for the triclinic space group P-1) are: a 7.413(1), b 26.944(4), c 6.051(1) Å, α 90.05(1), β 97.65(1), γ 91.82(1)°, V 1197.1(3) Å3, pickeringite (for the monoclinic space group P21/c): a 6.1808(8), b 24.252(2), c 21.220(2) Å, β 100.36(1)°, V 3128.8(6) Å3 and melanterite (for the monoclinic space group P21/c): a 14.022(5), b 6.503(2), c 10.945(4) Å, β 105.83(3)°, V 960.2(7) Å3. Sideronatrite and epsomite were identified in mixture with the most significant diffraction maxima for sideronatrite: 10.252/100, 4.905/37, 3.424/10, 3.067/9 and epsomite: 5.347/18, 5.302/18, 4.489/26, 4.215/100, 4.201/59, 2.880/24, 2.747/23, 2.677/18. Accumulations of minerals were formed on the mine walls. Secondary sulphates are considered as products of the weathering of Fe-rich carbonates, pyrite and other sulphidic minerals which are part of associated pelosiderites embedded in the clays and claystones. Locally, gypsum and hexahydrite were also identified in the form of transparent crystals and white powdery aggregates on the calcite speleothems genetically linked to Mesozoic limestones and gypsum-rich Lower Triassic Werfen Formation. Unit-cell parameters refined from X-ray powder diffraction data are for hexahydrite (for the monoclinic space group C2/c): a 10.107(1), b 7.2114(8), c 24.424(3) Å, β 98.28(1)°, V 1761.7(3) Å3.
State Description without State
Authors: Bodnár-Király Tibor
Published: December 2022

This study examines the reception of the state sciences in eighteenth-century Hungary. It argues that the genres of historical topography and political geography had a substantial role both in the adaptation of state description (Staatsbeschreibung) and in initiating the conflict between various state visions, based on the reappraisal of historical, legal arguments of the dualist political structure on the one hand, and the natural law-based conceptualisation of composite state (Gesamtstaat) and good administration (Gute Polizey), on the other. The essay claims that this opposing conceptualizations of state also contributed to laying the intellectual foundations for diverse Catholic and Protestant interpretations, developed throughout the eighteenth century. The article comes to the conclusion that until the late eighteenth century the two main competitive lines of state description fundamentally shaped the sociocultural contexts of knowledge of state. In the approach and method, however, these interpretations had different answers to the challenge represented by statistical knowledge. While Catholic history of state appeared less effective against statistical account, statisticians found fierce competitors in the protagonists of political geography.
Russian Sources on Bosnia and Herzegovina under Austro–Hungarian Rule, 1878–1908
Authors: Pakhomova Lidia
Published: December 2022

The article provides a brief overview of Russian historical sources on the history of Bosnia and Herzegovina in the period of the Austro–Hungarian occupation. The body of literature on the subject includes a wealth of work devoted to Austria–Hungary’s modernisation policies in Bosnia and Herzegovina between 1878 and 1914. However, researchers have not yet considered how the Great Powers that made important decisions about the fate of the provinces appraised the governance model of the Austro–Hungarian Empire. Such decisions were made not only on the basis of foreign policy interests and international relations, but also on the basis of observations from the occupied territories. Russian analysts closely explored the development of the provinces in the multi-ethnic Habsburg Monarchy between 1878 and 1908. Russian officials realised that the situation in the multireligious region was very complicated. They analysed both how Austria–Hungary managed this situation as an empire, and their governance model from the point of view of another empire.
How Tall Were the Jews?
Authors: Bolgár Dániel
Published: December 2022

The widespread belief that the Jews were far more affluent than the non-Jews in Hungary in the decades before the Holocaust lacks sufficient empirical corroboration. The present study aims to present the income disparity between Jews and non-Jews in the light of anthropometric data. A review of the physical anthropological literature concerning height and menarcheal age of Jews from the 1850s until World War I, together with an analysis of height data from the 1913 conscription and measurements of physical fitness involving schoolchildren between 1886 and 1916, suggest that the Jews’ biological standard of living was higher than that of non-Jews, although the inverse was true in the upper stratum of society.
Marija Gimbutas 100
Authors: Bánffy Eszter
Published: December 2022

Prehistoric archaeologist and cultural anthropologist Marija Gimbutas was born exactly a century ago. Although she left us over a quarter of a century ago (she passed away in 1994), her person and her still controversial ideas continue to attract considerable interest, reflected both by the acclaim and the harsh critique that her work and theories have received and continue to receive. In light of recent archaeogenetic findings and their interpretation, the debate has even intensified over the past few years.
Low skeletal muscle mass predicts poor prognosis of elderly patients after emergency laparotomy: A single Asian institution experience
Authors: Tan Edmund Wooi Keat , Yeo Jia Yi , Lee Yao Zong , Lohan Rahul , Lim Woan Wui , Lee Daniel Jin Keat
Published: December 2022

Introduction: Sarcopenia, defined as low skeletal muscle mass and poor muscle function, has been associated with worse postoperative recovery. This study aims to evaluate the significance of low muscle mass in the elderly who require emergency surgeries and the postoperative outcomes.
Method: Data from the emergency laparotomy database were retrieved from Khoo Teck Puat Hospital, Singapore, between 2016 and 2019. A retrospective analysis was performed on patients aged 65 years and above. Data collected included skeletal muscle index (SMI) on computed tomography scan, length of stay, complications and mortality. Low muscle mass was determined based on 25th percentile values and correlation with previous population studies.
Results: A total of 289 patients were included for analysis. Low muscle mass was defined as L3 SMI of <22.09cm2/m2 for females and <33.4cm2/m2 for males, respectively. Seventeen percent of our patients were considered to have significantly low muscle mass. In this group, the length of stay (20.8 versus 16.2 P=0.041), rate of Clavien-Dindo IV complications (18.4% vs 7.5% P=0.035) and 1-year mortality (28.6% vs 14.6%, P=0.03) were higher. Further multivariate analysis showed that patients with low muscle mass had increased mortality within a year (odds ratio 2.16, 95% confidence interval 1.02–4.55, P=0.04). Kaplan-Meier analysis also shows that the 1-year overall survival was significantly lower in patients with low muscle mass.
Conclusion: Patients with low muscle mass have significantly higher post-surgical complication rates and increased mortality.

Keywords: Emergency laparotomy, geriatrics, mortality, postoperative outcome, sarcopenia
Drug interactions between common dermatological medications and the oral anti-COVID-19 agents nirmatrelvir-ritonavir and molnupiravir
Authors: Quah Kathleen Shu-En , Huang Xiaoling , Renia Laurent , Oon Hazel H
Published: December 2022

Introduction: The oral antiviral agents nirmatrelvir-ritonavir (NMV/r) and molnupiravir are used to treat mild-to-moderate COVID-19 infection in outpatients. However, the use of NMV/r is complicated by significant drug-drug interactions (DDIs) with frequently prescribed medications. Healthcare professionals should be aware of the possible risk of DDIs, given the emergence of COVID-19 variants and the widespread use of oral COVID-19 treatments. We reviewed available data on DDIs between NMV/r, molnupiravir and common dermatological medications; summarised the potential side effects; and suggest strategies for safe COVID-19 treatment.
Method: A systematic review using PubMed was conducted on data published from inception to 18 July 2022 to find clinical outcomes of DDIs between NMV/r, molnupiravir and dermatological medications. We also searched the Lexicomp, Micromedex, Liverpool COVID-19 Drug Interactions database and the National Institutes of Health COVID-19 Treatment Guidelines for interactions between NMV/r and molnupiravir, and commonly used dermatological medications.
Results: NMV/r containing the cytochrome P-450 (CYP) 3A4 inhibitor ritonavir has DDIs with other medications similarly dependent on CYP3A4 metabolism. Dermatological medications that have DDIs with NMV/r include rifampicin, clofazimine, clarithromycin, erythromycin, clindamycin, itraconazole, ketoconazole, fluconazole, bilastine, rupatadine, dutasteride, ciclosporin, cyclophosphamide, tofacitinib, upadacitinib, colchicine and systemic glucocorticoids. With no potential DDI identified yet in in vitro studies, molnupiravir may be an alternative COVID-19 therapy in patients taking medications that have complicated interactions with NMV/r, which cannot be stopped or dose adjusted.
Conclusion: NMV/r has significant DDIs with many common dermatological medications, which may require temporary discontinuation, dosage adjustment or substitution with other anti-COVID-19 agents such as molnupiravir.

Keywords: COVID-19, dermatology, drug interactions, molnupiravir, nirmatrelvir-ritonavir, pharmacology
CONGENITAL ZIKA VIRUS SYNDROME-RELATED ANOMALIES DETECTED OVER THE SEVEN-YEAR HISTORY OF THE EPIDEMIC: A LITERATURE REVIEW
Authors: ALVES DE MORAES ALEXA , DeMaman Aline dos Santos
Published: December 2022

Background: In 2015, an alarming increase in microcephaly was recorded in Brazil, being associated to Zika virus (ZV) epidemic. The teratogenic effects of ZV, however, are not restricted to microcephaly only. Aim: To describe the body structures affected by the teratogenic potential of Zika virus congenital syndrome (ZVCS), in order to provide an overview of the anomalies detected and make this knowledge available to health professionals and to the scientific community. Methods: A narrative review was carried out between June 2020 and January 2022 in Portal de Periódicos CAPES, MEDLINE, Scopus, LILACS and SciELO databases. Scientific publications that addressed fetal organic structures that were affected by the teratogenic effects of ZVCS were included. Results: Thirty-two studies were included in this review and identified anomalies in cranium, orofacial structures, nervous system, joints, visual pathway and thoracic viscera. Conclusion: The teratogenic effects of ZVCS affect a broad spectrum of body structures. The children affected by ZVCS still require multidisciplinary health approach, so the present study is a helpful source of information for such professionals.
GEOTERAPIA: o “poder da terra” na saúde humana
Authors: Gomes Saulo de Almeida , Lima Islene Alves de , Santos Maria Eduarda da Silva , Barboza Marcelo Loer Bellini Monjardim , Albuquerque Helder Neves de
Published: December 2022

O objetivo desse estudo foi analisar a utilização da geoterapia como terapia complementar na manutenção da saúde humana. A metodologia utilizada neste trabalho foi a revisão bibliográfica da literatura, utilizando a base de dados nos sites eletrônicos (Google Acadêmico e Scielo). O intervalo de tempo dos artigos pesquisados foi entre 2017 e 2022, porém, utilizou-se também, artigos com datas anteriores foram usados, devido a importância de seus conteúdos e a relativa escassez de informações a respeito da temática. A coleta de dados se deu entre os meses de agosto a novembro de 2022. o uso da Geoterapia como função terapêutica e medicinal verificou-se que o uso da argila evidencia cada vez mais a ideia que já está sendo praticada por diversas áreas na sociedade, que é a utilização do solo como recursos naturais para o tratamento de questões físicas e mentais. Percebe-se que as práticas integrativas complementares na saúde vem ocupando um lugar de destaque nos cuidados complementares nos sistema de saúde público e privado.
ANÁLISE AMBIENTAL DO CEMITÉRIO PÚBLICO MUNICIPAL “PAZ DO SENHOR” EM CABEDELO-PB, BRASIL
Authors: Silva Ana Vitoria Dantas Fernandes da , Barbosa Filho Fábio Augusto Dias , Albuquerque Helder Neves de
Published: December 2022

Atualmente, os cemitérios públicos no estado da Paraíba encontram-se irregulares e localizados em áreas inadequadas, causando uma diversidade de sérios impactos ambientais de acordo com as Resoluções do CONAMA quanto ao licenciamento ambiental de Cemitérios. Diante disso, o presente estudo teve como objetivo realizar um diagnóstico ambiental para avaliar os impactos ambientais e as adequações às resoluções CONAMA, em vigor, junto ao cemitério público Municipal Paz do Senhor em Cabedelo-PB, Brasil. Assim, foi realizada uma pesquisa exploratória e de caráter descritivo no período do mês de novembro de 2022, com uso de observação in loco na área de estudo, técnicas de geoprocessamento e uso de Checklist. Através do diagnóstico ambiental verificou-se que o cemitério estudado não está em consonância com a legislação vigente no Brasil, especificadas nas Resoluções CONAMA nº 335, 368 e 402, dessa forma caracterizando-se com um grande potencial poluidor acarretando possibilidade de diversos impactos ambientais. Portanto, o referido cemitério, nas atuais condições de funcionamento é uma possível fonte de contaminantes prejudiciais à qualidade de vida da população e ao meio ambiente na cidade de Cabedelo-PB.
Parental Involvement in Schools: A Multi-site Study at Kuin Utara 4 and Sungai Jingah 4 Elementary Schools in Banjarmasin
Authors:   Master in Educational Administration, Universitas Lambung Mangkurat, Banjarmasin, Indonesia, Mahrianti Mery , Hadi Sutarto , Saleh Muhammad
Published: December 2022

This research was derived from the reality of public schools, where the majority of students coming from low-income and lower-middle-family backgrounds. However, they could manage parental involvement so that they are actively involved in various school programs. Thus, the focus of this research included: (1) planning for parental involvement in schools; (2) the implementation of parental involvement in schools; (3) evaluation of parental involvement in schools; and (4) obstacles encountered in parental involvement in schools. The researchers used a qualitative type of multi-site study. The data were collected through participant observation techniques, in-depth interviews, and documentation. The data analysis techniques used were individual data analysis techniques and cross-case analysis. Meanwhile, the validity of the data was checked by means of internal validation, external validation, reliability, and objectivity. The results of this study showed that: (1) participation planning was carried out at the beginning of the school year involving parents, principals, and teachers with funding sources for participation planning activities from infaq and dues with the stipulated period for one year; (2) the implementation of parental involvement includes participation in incidental, daily, weekly, monthly, semester, and yearly activities; (3) evaluation of parental involvement involving committees, principals, and teachers; (4) obstacles to parental involvement in schools included the assumption that schools are free, lack of support for the development of children's talent interests, the resolution process involves principals, teachers, committee administrators, overcome by approaching, providing understanding, and socialization. From the results of this study, it was concluded that the school has developed parental involvement in various school programs. It is especially advisable for principals to embrace and trust parents to be involved in the planning, implementation, evaluation, and resolution stages of obstacles. Thus, parents will feel more needed by the school and contribute their abilities in helping to improve the quality of education in schools both in the short and long term.
Effective Governance and Development of Apparatus Resources through Coaching Mentoring and Counseling at the Jember Customs
Authors:   public administration doctoral program, Jember University, Indonesia, Triswanto Maksi Drivandi Madya , Purwowibowo Purwowibowo , Sukristyanto Agus , Helpiastuti Selfi Budi
Published: December 2022

This research aims to; a) explain the model of effective human resource governance through coaching mentoring and counseling (CMC); b) explain the performance achievements of the apparatus in managing Jember customs; and c) explaining the behavior of public administration within the framework of apparatus governance through a psychological assessment approach using the CMC method. This research uses qualitative methods with a focus on ASN governance at Jember Customs and Excise. Determination of informants using a purposive method, so that in this study there were 9 people with different roles. Data collection uses observation techniques, in-depth interviews, documentation, and literature study. All data is processed through three stages, including data reduction, data presentation, and drawing conclusions. The results showed that Jember Customs and Excise carried out psychological and CMC assessments in order to make existing resources effective. The assessment method using the CMC approach has been successful as seen from ASN's performance achievements in governance at Jember Customs and Excise. The CMC that is implemented provides enlightenment for ASN in providing services to the community. CMC also has an influence on increasing accountability through performance measurement. One of the parameters for achieving individual employee and organizational goals is reflected in the increase in the service user satisfaction index at Jember Customs where in 2021 it will get an index of 4.21 to 4.43. Service users also provide very satisfied ratings of the various types of services provided by Jember Customs and Excise employees.
TRANSFORMASI JURNALISME PERJALANAN TIGA MEDIA: DARI KONVENSIONAL MENUJU ONLINE
Authors: Wardaningsih Agustin Diana
Published: December 2022

Budaya orang untuk melakukan perjalanan masih sangat tinggi, sehingga informasi tentang suatu obyek wisata pun masih terus dibutuhkan. Dengan perkembangan teknologi terutama media baru, membuat orang mudah menemukan panduan untuk melakukan perjalanan ke berbagai tempat yang ingin dikunjungi. Dahulu, informasi tentang panduan perjalanan dan obyek wisata awalnya meningkat lewat media konvensional. Hampir setiap stasiun TV memiliki progam khusus yang mengulas tentang perjalanan, dan publikasi lewat media cetak seperti koran dan majalah juga mendukung kegiatan pariwisata. Saat muncul media online sebagai perkembangan dari media baru, informasi tentang obyek wisata bergeser ke media online. Tujuan penelitian ini untuk melihat penerapan konsep jurnalisme perjalanan pada media Online. Penelitian ini menggunakan pendekatan kualitatif, dengan metode studi kasus (case study) instrumental tunggal yang fokus pada isu yaitu transformasi tiga majalah travel cetak sebagai media konvensional, pada tampilan dan perubahannya lewat media online. Transformasi liputan perjalanan yang terlihat pada versi online adalah keberagaman topik pembahasan, dan tidak fokus hanya mengikuti tema tertentu yang dipilih seperti layaknya pada versi cetak. Inovasi juga muncul pada versi online adalah bukan hanya menawarkan teks dan gambar, tetapi juga ada video audiovisual yang lebih menarik bisa dinikmati. Era digital telah membawa perubahan pada praktek jurnalisme konvensional termasuk di dalamnya kemasan jurnalisme perjalanan ke dalam media online dengan karakteristik produksi dan distribusi yang cepat, tapi tetap akurat dan bisa dipercaya.
ANALISIS YURIDIS TINDAK PIDANA ABORSI DALAM PASAL 75 AYAT (2) UNDANG-UNDANG NOMOR 36 TAHUN 2009 TENTANG KESEHATAN
Authors: Laura Puja Malar , Husin Umar
Published: December 2022

Semakin maraknya kasus-kasus kehamilan pranikah, menjadikan semakin marak pula kasus aborsi yang dilakukan oleh pasangan-pasangan di luar nikah. Penelitian ini mengkaji mengenai pertanggungjawaban pidana dalam tindak pidana aborsi yang dilakukan oleh wanita yang belum menikah dan tidak memenuhi indikasi kedaruratan medis melakukan aborsi dalam perspektif Undang-Undang Kesehatan dan dasar pertimbangan hukum yang dipakai oleh penulis adalah Putusan Pengadilan Nomor 31/Pid.Sus/2018/PN.Byl. Penelitian ini adalah penelitian hukum normatif yang bersifat deskriptif, dengan menggunakan pendekatan Undang-Undang dan pendekatan kasus. Jenis data yang digunakan adalah data sekunder yang meliputi bahan hukum primer, sekunder, dan tersier. Teknik pengumpulan data yang digunakan adalah studi kepustakaan. Teori-teori yang digunakan dalam penelitian ini diantaranya adalah teori kepastian hukum, teori penegakan hukum, teori perlidungan hukum, teori pembuktian, teori pertimbangan hukum, dan teori tujuan pemidanaan. Sehingga analisa dalam penelitian landasan pada teori-teori tersebut. Berdasarkan analisa yang dilakukan oleh penulis diperoleh kesimpulan bahwa latar belakang pelaku melakukan tindak pidana aborsi dalam kasus ini disebabkan karena dua faktor yaitu faktor internal dan faktor eksternal pelaku. Penulis menyimpulkan bahwa Putusan Hakim dalam memutus perkara perempuan yang berhadapan dengan hukum sudah sangat jelas dengan mempertimbangkan kerugian yang dialami korban; dampak dari kasus baik secara fisik, psikis, sosial dan ekonomi; kondisi perempuan yang masih muda; potensi bahaya yang mengancam nyawa; serta keadaan perempuan sebagai pelaku yang menyesali perbuatannya dan berjanji tidak akan mengulangi perbuatannya tersebut. Penerapan Hukum Pidana Materil pada Putusan Pengadilan Nomor 31/Pid.Sus/2018/PN.Byl, menggunakan Asas Lex specialis derogat legi generalis yaitu suatu asas penafsiran hukum yang menyatakan bahwa hukum yang bersifat khusus (lex specialis) mengesampingkan hukum yang bersifat umum (lex generalis).
ANALISIS PENGARUH GOOD CORPORATE GOVERNANCE DAN INTELLECTUAL CAPITAL TERHADAP NILAI PERUSAHAAN IDXESGL30
Authors: Herdani Emir Fikri , Kurniawati Rossita
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh intellectual capital melalui VAICTM (VAHU, VACA dan STVA) dan good corporate governance melalui variabel Kepemilikan Manajerial, Kepemilikan Institusional, Komposisi Komisaris Independen dan Kualitas Audit terhadap Nilai Perusahaan. Penelitian ini adalah penelitian kuantitatif. Populasi penelitian adalah perusahaan yang terdaftar dalam indeks IDXESGL, dan sampel penelitian adalah sejumlah 30 perusahaan. Dalam penelitian ini data yang digunakan adalah data sekunder. Analisis yang digunakan dalam penelitian ini adalah analisis analisis deskriptif, uji koefisien determinasi (R2), Uji Regresi Linier Berganda, goodness of fit, uji signifikansi parameter individual (uji t) dengan menggunakan program SPSS versi 25. Hasil penelitian ini menunjukan bahwa : (1) variabel intellectual capital tidak berpengaruh signifikan terhadap nilai perusahaan; (2) variabel kepemilikan manajerial tidak berpengaruh signifikan terhadap nilai perusahaan; (3) variabel kepemilikan institusional tidak berpengaruh signifikan terhadap nilai perusahaan; (4) komposisi komisaris independen berpengaruh positif terhadap nilai perusahaan; dan (5) kualitas audit tidak berpengaruh signifikan terhadap nilai perusahaan.

 
Islamic Boarding School (Pondok Pesantren) , Independent And Community Empowerment
Authors: Purwoko Dwi
Published: December 2022

Implementation of the learning system at Islamic Boarding Schools (Pondok Pesantren – commonly called in Indonesia) usually leaves an imprint in the memory of the students who in turn will make it perspective that can be applied in their everyday lives, both in their ways of thinking and when they make good deeds blessed by the God. In addition, the Islamic Boarding School that plays strategic roles and has long been rooted in the Indonesian society has its own force in arousing the spirit and passion of the students to advance towards more prosperous and independent life. The values learned in the school, in particular its values of self-reliance, have encouraged the santri to practice these values in the society. Coming from such background, this research aims to provide an overview of the boarding schools that teach independent life to the students who in turn, when they graduate, they may empower the community in which they live.Penerapan sistem pembelajaran di Pondok Pesantren biasanya meninggalkan jejak dalam ingatan para santri yang pada gilirannya akan menjadikannya cara pandang yang dapat diterapkan dalam kehidupan sehari-hari, baik dalam cara berpikirnya. dan ketika mereka melakukan perbuatan baik yang diberkati oleh Tuhan. Selain itu, Pondok Pesantren yang memiliki peran strategis dan telah lama mengakar dalam masyarakat Indonesia memiliki kekuatan tersendiri dalam membangkitkan semangat dan gairah santri untuk maju menuju kehidupan yang lebih sejahtera dan mandiri. Nilai-nilai yang dipelajari di sekolah, khususnya nilai-nilai kemandirian, telah mendorong santri untuk mengamalkan nilai-nilai tersebut di masyarakat. Berangkat dari latar belakang tersebut, penelitian ini bertujuan untuk memberikan gambaran tentang pesantren yang mengajarkan kehidupan mandiri kepada para santrinya yang pada gilirannya kelak ketika mereka lulus dapat memberdayakan masyarakat di mana mereka tinggal.
Cooperation Maxim Error Principles and Implications on Warintil Official Series “Ga Boleh Souzon”
Authors: Passandaran Yosi Maeleona , Zaimar Yulia Sofiani , Tiwiyanti Leni
Published: December 2022

This article would like to describe the error of maxims and also the meaning of implicatures in the sitcom of Kontrakan Rempong from Warintil Official on Youtube. There were five types of violations of the cooperative principle caused by the speech participants.  The research method used in this research is descriptive qualitative. The data is taken from Kontrakan Rempong, titled “Gak Usah Souzon”.  The collecting data are using the documentation method by listening and note-taking techniques from the Kontrakan Rempong’ characters' conversation. Meanwhile, the object of this research is the form and meaning of implicature in humour Kontrakan Rempong. The results of this research indicate the form of conversational implicatures that function as a supporter of humour in humorous discourse, they are:  the Youtube  Kontrakan Rempong has a violation of the maxim of the cooperative principle. In the maxim of quality, there are two categories of violations; they are the words that are used solely to show her or his arrogance and to make the main character a fool. In other words, the error maxim is seemed as trying to evade responsibility. The function of violation of the Maximal Principle of cooperation has been categorized based on existing data like wisdom maxim, acceptance maxim, humility maxim, quality maxim, approbation maxim and quantity maxim. The maxims error is the error of quantity maxim, quality maxim, wisdom maxim approbation and humility maxim. In addition to supporting humour, the error causes many implications related to human nature and real life.

Keywords: humour, error, maxim, implicature

 
Simile Expressions in ‘Everything at Once’ Song Lyrics by Lenka
Authors: Yuliasari Ria , Virtianti Rika
Published: December 2022

In this digital era 4.0, more and more people are realizing the importance of learning foreign languages, especially English. They learn through any source they can access digitally and one of the media used is through music and songs. But actually learning English through songs has its own challenges because song lyrics are often different from spoken language, one of which is the use of language style. This research aims at analyzing simile expressions found in the song lyrics of ‘Everything at Once’ by Lenka. The method used in this research is descriptive qualitative to analyze the types of simile expressions found in the song lyrics. The analysis of the types of simile expressions is carried out using theory of Zhang and Fromilhague. The result of analysis shows that ‘Everything at Once’ song has 38 simile expressions and they all belong to the type of closed and explicit simile.

 

Keywords: simile, song, lyrics.
Reduction of Heavy Metal Pollution Using Brown Algae: A Review
Authors:   Department of Physics, Panimalar College of Engineering (City Campus), Nungambakkam, Chennai, India, Sreevani K
Published: December 2022

Industrial heavy metal pollution and other effluents from chemical industries are of great concern for the ecosystem. Due to this, toxic waste water is released into the environment causing severe heavy metal pollution and also affects our health. The physicochemical methods are expensive and these results in the incomplete removal of metal ions. As a result, other alternative methods such as algae bioremediation are taken into account which have the ability to absorb metal ions and this very idea can be used in the treatment of wastewater. They absorb metal ions on the cell surface and in the intracellular ligands. Before releasing algae into waste water, they are treated with pretreatment. Various pretreatment improves the enhancement of metal sorption in algae. The most suitable and economic method for cultivating algae biomass is the calcium chloride pretreatment. When considering algae, there are various strains and hence, selection of strain is highly important. This happens by the understanding of bio sorption mechanisms, increasing the number of surface groups with genetic manipulation of algae and creating them for economic feasibility. In brown algae, the order Laminariales and Fucale species are considered as efficient groups of algae while bio-sorption is considered, because their cell wall is very rich in extracellular polymers and polysaccharides. Considering these parameters in the significant development of low-cost algae cultivation and an eco-friendly solution for the pollution caused by chemical industries, this work concentrates on the bioremediation process for the reduction of heavy metal pollution.
Research Based Original Work
Authors:   Packaging and Polymer Science, Bioxytran Inc, Boston, USA, Chanda Anupam
Published: December 2022

I have been involved in basic research for more than 10 years for innovation of wide range of pharmaceutical products new “Packaging design for Drug delivery” like “Solid doses, Injectables (for anti-cancer, HIV, wide range of vaccines, Covid -19 drugs and Biosimilar products) in “Microgravity Environment like MARS mission. Looking at the present ecological imbalance Scientists are thinking for multiplanetary living system in order to survive human species. As we know different planets having critical climatic conditions and Packaging will play a vital role. We as a scientist have clear vision about things are going to happen after 100 years in other planets and from now we have to keep ready “Packaging designs and delivery systems” for life savings drugs and essential medicines for Astronauts and visitors.
Intertextualidade e desqualificação do adversário no uso da hashtag em tuítes
Authors: Dutra Rafael Botelho , Faria Maria da Graça Dos Santos
Published: December 2022

A internet intensificou discursos que se entrecruzam antagonicamente. Desse modo, esta pesquisa se propõe a analisar a intertextualidade em hashtags utilizadas em textos da rede social Twitter, a fim de que se possa apreender a desqualificação do adversário na polêmica pública. A fundamentação teórica recorre aos estudos sobre a polêmica pública (AMOSSY, 2017), à classificação do argumento ad hominem (FIORIN, 2015), ao tecnodiscurso (PAVEAU, 2020) e à intertextualidade no que diz respeito à alusão ampla (CARVALHO, 2018). Para a análise, foram selecionados dois tuítes produzidos em dois contextos polêmicos distintos que envolvem a conduta do presidente Jair Bolsonaro com questões de interesse para a sociedade brasileira. A análise permitiu constatar que a intertextualidade intensifica o ataque direcionado à pessoa ou ao grupo que assume o lado oposto na polêmica pública, ao fazer uso da hashtag em textos virulentos na rede social Twitter.
A argumentação no tribunal do júri: emoção e empatia do advogado de defesa em casos de homicídio
Authors: Silva Karla Stéphany De Brito , Rodrigues Maria das Graças Soares
Published: December 2022

Analisar a argumentação presente na sustentação oral de um advogado que defende um réu homicida e a sua relação com o convencimento dos jurados é o propósito deste trabalho. Dessa forma, fundamenta-se na nova retórica de Perelman e Olbrechts-Tyteca (1996); na sequência argumentativa de Adam (2011), em diálogo com as teorias de emoção, com Plantin (2011) e empatia com Rabatel (2013). Com a finalidade de padronizar a transcrição do corpus, ele foi passado para as normas do Projeto da Norma Urbana Oral Culta (NURC). A análise do dado aponta para os seguintes resultados: a sequência argumentativa seguiu o nível justificativo; sobre o argumento emocional, notamos que foi marcado por lexemas subjetivos; por fim, sobre o argumento empático, verificamos que os mais recorrentes foram a de que L1/E1 se colocar no lugar dos jurados, para evitar arrependimentos futuros, e, o do L1/E1 se colocar no lugar da mãe da vítima.
The role of reported speech in the evaluation of arguments from expert opinion
Authors: Serafim Monielly
Published: December 2022

This paper discusses how grammatical aspects of direct and indirect speech affect the evaluation of the argument from expert opinion. Direct speech is often characterized by having two different discourse acts and, consequently, two deictic centres; and indirect speech is regarded as one discourse act with one deictic centre. These grammatical structures have different pragmatic effects, mainly because in direct speech, the reported content is assumed to be faithful in form and content. In contrast, in indirect speech, the current speaker embeds the reported content in their speech. Considering these features, this work provides a comparative analysis of the types of reported speech and their relation to Wagemans’ (2011) argument scheme and critical questions and offers modifications in the existing argument schemes to allow a more precise evaluation of arguments.
A argumentatividade nos imaginários sociodiscursivos de intolerância: uma análise da polêmica gerada por comentários sobre um discurso religioso
Authors: Nunes Karina Zandonadi , Melo Mônica Santos de Souza
Published: December 2022

A partir de uma polêmica causada pela postagem de um vídeo no Twitter do Papa Francisco, inúmeros comentários intolerantes foram veiculados como forma de resposta a tal publicação. Isso foi possível graças ao processo de midiatização do discurso religioso e também a diferentes acontecimentos políticos, responsáveis por uma polarização da sociedade brasileira. Nosso objetivo é analisar a argumentatividade presente em tais respostas a partir das noções de imaginários sociodiscursivos, de Charaudeau (2008, 2009, 2015), e também o conceito de temática, proposto por Barros (2011) e Melo (2020). Identificamos cinco imaginários sociodiscursivos de intolerância entre os comentários analisados e os classificamos em quatro tipologias diferentes. Nossas investigações apontam para o entendimento de que a intolerância verbal presente nas respostas possui forte sentido de argumentatividade social, uma vez que este tipo de discurso não se limita ao ambiente cibernético, mas reflete a sociedade intolerante na qual estamos vivendo.