bluuebunny/crossref_metadata_2025 huggingface dataset:
Diabetes Patients Compliance Towards Routine Care Schedule at Health Care Centers During Covid-19 Pandemic
Authors: Pratama Rezha Andico Eka , Widyaningsih Susana
Published: August 2023

Background: One of the major health problems of the twenty-first century is chronic disease, which sometimes has the potential to get worse. Chronic diseases of concern include cardiovascular, cancer, chronic respiratory, and diabetes mellitus. The total of Diabetes Mellitus in Hospital in 2022 is 140 patients. During the Covid-19 pandemic, many people with diabetes mellitus did not undergo routine treatment at the hospital, they said they were afraid to go to the hospital because they received information that the hospital was more susceptible to Covid-19, so patients were reluctant to go for routine treatment. Objective: The objective of this study is to describe the compliance of diabetes mellitus patients to undergo routine care at the Health Service Center during the Covid-19 pandemic. Method: This study uses quantitative research methods. The design used in this study is a cross sectional approach. The location of the research was in Ajibarang Hospital and Ajibarang Health Center. Results: This study concluded that the level of patient compliance in routine care during the Covid- 19 pandemic was in the moderate category. With an average value of the total "Yes" answer of 71%, and it falls in the 51%-80% interval. Conclusion: There is a description of the compliance of diabetes mellitus patients with routine care during the covid-19 pandemic in the high category, which is 95%.
Guided Imagery Relaxation: Therapy to Reduce Anxiety Level Before Competing Pencak Silat Athletes
Authors: Bella Melly Kar , Hikmawati Isna
Published: August 2023

Background: Pencak Silat athletes have high emotional reactions in competing so that anxiety will arise in these athletes. Guided imagery (GI) is a technique that relies on descriptive language to facilitate auditory visualization of calming images with the aim of achieving a relaxation response. Objective: To determine the effect of guided imagery relaxation therapy on anxiety before competing in pencak silat athletes in Tapak Suci. Methods: Experimental research with a pre-experimental design (one group pretest-posttest). The research instrument used the Hamilton Rating Scale for Anxiety (HRS-A). The sampling technique used total sampling with the number of respondents as members of pencak silat as many as 30 people from the University of Muhammadiyah Purwokerto silat. Results: The level of anxiety before the match in the moderate category was mostly 46.7% and severe anxiety was 30%, and after being given therapy most of them did not experience anxiety as much as 46.7% and mild anxiety as much as 43.3%. There is an influence of guide imagery on anxiety before competing in pencak silat athletes at the University of Muhammadiyah Purwokerto with a p-value of 0.001 (<0.05). Conclusion: The importance of non-pharmacological therapy to reduce anxiety before competition, so that match readiness is more optimal.
Health Education About Tepid Water Sponge Efforts to Increase Family Knowledge and Skills in Handling Fever
Authors: Nanda Rama , Hikmawati Isna
Published: August 2023

Fever is a condition of an increase in body temperature above normal. Parents, especially mothers, have an important role in dealing with children with fever, however, not many mothers have the knowledge and skills in early handling of fever, one of which is the tepid water sponge. The purpose of this study is to provide health education about handling fever using the tepid water sponge method.This research with pre-experimental design (one group pretest-posttest). The sample in this study amounted to 30 mothers who have children aged 1-5 years and registered at the Posyandu Bantarkawung Village. Bumiayu District, Brebes Regency. Samples were taken by total sampling technique. Collecting data using a questionnaire sheet for the level of knowledge and observation sheets for skills. Data analysis using paired sample t test. The results showed that the skills before health education were 28 (93.3%) lacking in skills and decreased to 14 people (46.7%) after the intervention. The level of lack of knowledge was 14 (46.7%) and decreased to 5 (16.7%) after the health education intervention. There is a relationship between health education about the tepid water sponge on knowledge and skills in handling fever in the family (p value 0.000). Good public understanding is needed, how to deal with fever in the family through health education.
The Correlation Between the Husband's Support and the Psychological Well-Being of Pregnant Adolescents
Authors: Zahrifa Zike , Aniarti Reni Purwo
Published: August 2023

Background: Teenage pregnancy can be defined by the occurrence of pregnancy in girls aged 10-19 years who still have emotional instability. This emotional instability can affect the psychological well-being of pregnant adolescents, which will cause disturbances in their pregnancy; therefore, the husband's support is needed so that mothers can feel security and comfort in their pregnancy to achieve maternal and fetal health in the womb. Objective: To determine the correlation between husband's support and psychological well-being in pregnant adolescents. Method: This study used a quantitative method with a cross-sectional design. The sampling technique used total sampling with a total sample of 30 respondents. The study was conducted in the Moga Health Care Center Pemalang Regency, Central Jawa Province, Indonesia. Data analysis used is univariate analysis to determine the frequency distribution of respondent characteristics (age, number of pregnancies and education), and bivariate analysis to determine the relationship between independent variables (husband's support) with the dependent variable (psychosocial condition of adolescent pregnant women) Results: This study shows a significant correlation between husband's support and the psychological well-being of pregnant adolescents in the Moga Community Health Care Center, with a p-value of 0.000. Conclusion: Pregnant women who lack a husband's support will be at risk of experiencing psychological well-being in their pregnancy, especially pregnant adolescents.
Metode Pendidikan Akhlak Islam dalam Keluarga Terhadap Remaja di Dusun Ranjingan Klapagading Kulon Wangon Banyumas
Authors: Agustiana Rindi , Surya Mintaraga Eman
Published: August 2023

The character of adolescents who are emotional and do not have stability in choosing a way out has a high potential to direct adolescents to negative values or what is often known as juvenile delinquency, especially in the village of Ranjingan. Therefore, Islamic moral education from parents is important as a guide and provision for teenagers. in overcoming uncontrollable desires and emotions. The purpose of this study was to find out various methods of Islamic moral education in families in the village of Ranjingan for adolescents. This research is field research with data collection techniques reservation interviews, and documentation. Analysis of data related to the method of Islamic moral education in the family was analyzed qualitatively using the description method where data obtained from interviews, observations, and documentation will be described in option a general conclusion. This study resulted in the method of Islamic moral education used by parents in Ranjingan hamlet, namely the exemplary method, the advice method, the punishment method, and the habituation method as well as various other supporting methods that are not dominant in this Islamic moral education. The parents said that the Islamic moral education given to their teenagers was dominated by freedom of choice, and opinion determining mine the actions taken by teenagers when they behaved at home and in society, however, parents still provide supervision, although not with such involvement. dominant in the daily activities of the youth in the village of Ranjingan.
Cuckoo Search Algorithm untuk Menyelesaikan Bi-Objective Permutation Flowshop Scheduling Problem
Authors: Pratiwi Asri Bekti , Suprajitno Herry , Sarah Siti
Published: August 2023

Tujuan dari penelitian ini adalah menyelesaikan permasalahan Bi-objective Permutation Flowshop Scheduling Problem (BPFSP) menggunakan Cuckoo Search Algorithm (CSA). BPFSP memiliki lebih dari satu fungsi tujuan yaitu meminimalkan makespan dan total tardiness. Program penerapan CSA untuk menyelesaikan BPFSP diimplementasikan dalam kasus dengan tiga jenis data yaitu data kecil dengan 5-pekerjaan 4-mesin, data sedang dengan 20-pekerjaan 10-mesin, dan data besar 50-pekerjaan 20-mesin dengan penggunaan beberapa nilai parameter yang bervariasi diantaranya maksimum iterasi, banyaknya sarang serta probabilitas pergantian sarang. Berdasarkan hasil running pada ketiga jenis data diperoleh bahwa semakin banyak jumlah sarang serta iterasi maka akan memberikan nilai fungsi tujuan BPFSP yang cenderung lebih baik. Sebaliknya, nilai fungsi tujuan BPFSP akan cenderung lebih baik jika nilai probabilitas pergantian sarang semakin kecil.
Optimization of Assignment Problems using Hungarian Method at PT. Sicepat Express Ambon Branch (Location: Java City Kec. Ambon Bay)
Authors: Meik Ardial , Ilwaru Venn Yan Ishak , Rijoly Monalisa E. , Tomasouw Berny Pebo
Published: August 2023

One of the special cases of problems in linear programming that is often faced by a company in allocating its employees according to their abilities is the assignment problem. The assignment problem can be solved using the Hungarian Method. In applying the Hungarian method, the number of employees assigned must be equal to the number of jobs to be completed. In this study, the Hugarian method was used to optimize the delivery time of goods from PT. SiCepat Express Ambon Branch – Java City. To solve the assignment problem at PT. SiCepat Express Ambon Branch – Java City, the required data includes employee names, destination locations, and delivery times. Before using the Hungarian method, the total delivery time of 7 employees at 10 destinations is 955 minutes. However, after using the Hungarian method, the total delivery time of 7 employees at 10 destination locations was 440 minutes. It can be seen that there are 515 minutes of time effisiency. We also Solved this assignment problem uses the QM For Windows Version 5.2 software and go the same amount of time, which is 440 minutes.
Chosŏn Entering the International Arena: Three Witnesses
Authors: Jungmann Burglind
Published: August 2023

The last decades of the Chosŏn dynasty (1392‑1910) are remembered as a period of inner turbulences and competition between foreign powers over their dominance of the Korean peninsula. Yet, during the crucial period from the mid-1880s to the early 1900s, Chosŏn was considered ready to independently enter the international arena. In the roughly twenty-five years between the first treaties with the USA and European countries and 1905, when Japan took charge of Korea’s foreign affairs, it sparked the interests of Western diplomats, adventurers, and travelers. The texts and images of three visitors during this period, Isabella Bird, Burton Holmes, and Jack London, present very different perspectives on Korea. Rather than seeking historical information, this study attempts to highlight these different views within their personal background and intentions. In addition to their publications, collections of unpublished photographs reveal a wider spectrum of experience and allow for a closer comparison between textual and visual representation.
Presence, Power, and Agency: Donor Portraits in Early Gandharan Art
Authors: Elahi Moizza S.
Published: August 2023

The aim of this paper is to shed light on locally constructed sculptural representations of donors and devotees from Butkara I in Swat valley – one of the earliest Buddhist sites in the Greater Gandhara region. The discovery of several sculptures and architectural elements depicting elaborately adorned male and female figures with distinctly individualizing facial features, and bearing varied Buddhist offerings, not only throws into relief the artistic phenomenon of portraiture in early Gandharan Buddhist art but also exemplifies the visual and material enactment of donative ritual and practice. The appropriation of a transcultural and widely legible visual vocabulary for constructing these essentially Buddhist figures underscores the complex cross-cultural interactions and encounters underpinning Gandharan art and Buddhist practice in the early centuries of the Common Era. The paper argues that, in addition to relic establishment and donative inscriptions, the ruling aristocrats used donor portraits for the material and metaphorical embodiment of their presence and piety within the Buddhist monastic space. Moreover, these images likely served as public performances for effectively navigating the broader political and socio-cultural currents. Speaking to diverse communities in the multicultural matrix of Gandhara, these donor portraits highlight the participation of visual imagery in constructing new forms of ritual and practice predicated upon the intertwined notions of power, patronage, and religiosity.
What Types of Feedback do Undergraduate Chemistry Students Give Each Other? A Case Study from Singapore
Authors: LIM Norman T-Lon , Lee Yew-Jin , Lee Peter Peng Foo
Published: August 2023

This study was part of a larger project to improve learning of undergraduate chemistry in Singapore through the use of self-authored three-tier multiple-choice questions (3TMCQs) and the giving/receiving of peer feedback. Specifically, we examined the quality of written feedback based on the classification by Hattie and Timperley (2007) that year 2 to 4 learners (N=31) gave each other on responses in their 3TMCQs (N=466 administered). It was found that the most common type of voluntary feedback given by test-makers was task (& self), followed by process (& self), self alone, and lastly regulation (& self) levels over seven chemistry courses. In addition, question type (based on revised Bloom’s Taxonomy) had a marginal effect on the quality of feedback received; instead, items answered incorrectly garnered higher quality feedback and were four times more important than the cognitive level of questions. Feedback quality given by more experienced students was also no better than those given by less experienced ones. While there is growing evidence supporting the self-authoring of questions and giving/receiving peer feedback to enhance learning at undergraduate levels, further research is warranted into the types of peer feedback that learners may receive when attempting different question formats.
Peranan Lembaga Filantropi Rumah Zakat dalam Tujuan Pembangunan Berkelanjutan (Sustainable Development Goals / SDGs) Di Kota Kediri
Authors: Bambang Hermantoro  , Zuraidah
Published: August 2023

Pembangunan Berkelanjutan (SDGs) merupakan agenda pembangunan dunia yang bertujuan untuk kesejahteraan manusia secara global yang diikuti oleh 193 negara termasuk Indonesia. SDGs memiliki 17 indikator, salah satunya mengurangi kemiskinan dan melindungi Bumi yang berkelanjutan. Rumah Zakat Kediri merupakan Filantropi islam yang mendukung terlaksananya SDGs di Indonesia. Metode penelitian yang di gunakan Kualitatif-deskrpitif. Hasil penelitian ini yaitu Rumah Zakat Kediri berkolaborasi dengan walikota kediri dan BPRS kota kediri. menerapkan sembilan indikator dalam pencapaian SDGs di kota Kediri, yaitu memberikan bantuan para kewirausahan dan pedagang kecil, meningkatkan SDM dan Skill masyarakat, memberikan beasiswa prestasi, kegiatan menanamkan rasa menyayangi likungan sekitar dan peduli kesehatan masyarakat.
Feasibility of Water Hyacinth Ash as an Accelerator in Cement Slurry Formulation
Authors: Neminebor Gift Pepe  , Adewole Steve  , Akpoturi Peters
Published: August 2023

Cement is primarily used in drilling operations to protect the casing against the corrosive tendency of formation fluid and to support the casing with the external load on and around it. Cement slurry is formed by mixing water with Portland cement or with cement containing various essential additives as the case may be and pumping it down through to critical points in the annulus around the casing using various techniques. Class G cement is widely used in cementing jobs because it allows the use of accelerators and retarders for wide range of well depths and temperatures. Due to wait-on-cement time before commencement of drilling of the next section of the well, it is necessary to reduce the waiting time and it ripple effects on cost of drilling by introducing accelerator to the cement slurry. The chlorides of calcium, potassium and sodium are the commonly used accelerators. Water hyacinth ash have been known to contain high percentage of calcium, potassium and chlorine, these elements readily combine with water to form potassium chloride and calcium chloride of which both are used as accelerator additives in cement slurry formulation. The utilization of these compounds in water hyacinth ash as accelerator additives would be a major breakthrough in cementing jobs especially in shallow section of the wells. Locally sourced water hyacinth plants were dried and combusted in air, the ash was then activated with water and filtered. The filtrate was used to determine the thickening time of class G cement slurry and the results obtained was compared with that of inorganic calcium chloride. The thickening times at the various set temperatures for this experiment were close to the inorganic calcium chloride used. Though, the thickening time of cement slurry is dependent on temperature, the concentration of the accelerator in the slurry also affect it.. It was found out that water hyacinth ash reduces the thickening time of class G cement slurry comparatively and therefore, should be considered as accelerator additive in the formulation of oil well cement slurry for accelerating the cement setting time.
ANALYSIS OF THE HYDROCHEMICAL REGIME OF THE DNIPRO RESERVOIRS
Authors: Yatsiuk M. V. , Mosiichuk Y. B. , Matselyuk Ye. M. , Mosiichuk A. B.
Published: August 2023

A complex of issues was considered, namely: hydro-chemical pollution of catchment landscapes, bottom sediments of river basins and groundwater, slowing down of underground flow due to the regulation of the river network, regional development of flooding, presence of landscapes contaminated with radionuclides, and the growth of global climate change. All above as well as the ongoing war in the territory of Ukraine affect the conditions of the formation of the hydro-chemical regime and contribute to the changes in the quantitative and qualitative water indicators in the Dnipro River basin and the Dnipro reservoirs, as the main sources of water supply for Ukraine. The research determined the changes in the hydro-chemical regime of the surface water of the Dnipro reservoirs during 2016-2022 to specify the impact of climate change and anthropogenic factors on the drinking water supply. The dynamics of changes were analyzed for individual qualitative indicators of the surface water of the Dnipro reservoirs in the cold (January) and warm (July) months of the year. It was proven that the accumulation of flood water affects the mineralization of the Dnipro reservoirs along their longitudinal axis, and the mineralization rate and the content of the main ions are significantly affected by the water content of the year. It was established that, in the Dnipro reservoirs, the lower limit of mineralization relative to natural conditions increased by 55%, and the upper limit decreased by 30%. It was determined that despite the seasonal changes in the concentration of ions in the water of the Dnipro reservoirs, their ratio for each reservoir remains practically constant and only sometimes changes in the case of a shift in the carbonate balance and in the confluence of more mineralized waters, which increase the content of Mg2, Na+, K+, and SO42-. The predominant water cation is Ca2+, the anion is HСО3-, and the absolute and relative content of other ions is much smaller. The metamorphism of the water of the Dnipro reservoirs changed the ratio of ion concentrations, namely the relative amount of SO42-, Cl-, Na+, and K+ ions increased. The obtained results of changes in the quality indicators of surface water in the Dnipro reservoirs have proved the dependence of the formation of the hydro-chemical regime of the reservoirs on the impact of climate change, economic activity, and the consequences of military actions.
DRIP IRRIGATION REGIMES AND EFFICIENCY OF WATER USE BY SUNFLOWER HYBRIDS
Authors: Kaliley V. V. , Shatkovskyi A. P. , Retman M. S.
Published: August 2023

The article presents the results of experimental research on the effect of drip irrigation system designs on the formation of irrigation regimes, productivity, and efficiency of water use by sunflower hybrids. In addition, the main components of evapotranspiration were taken into account, and coefficients of water consumption (WCC), irrigation efficiency (IE), and irrigation water use efficiency (WUE) were chosen as criteria for the efficiency of drip irrigation. Short-term field research was carried out during 2020-2022 on the lands of the Brylivske experimental field of the Institute of Water Problems and Reclamation of the National Academy of Agricultural Sciences (Kherson region, subzone of the Dry Steppe). Analytical and mathematical as well as statistical methods were used to process experimental data. The scheme of the three-factor field experiment provided various options for laying irrigation pipelines of drip irrigation systems (in the horizontal and vertical planes), as well as the implementation of a pulsed water supply mode (standard). The version with a natural moisture supply (without irrigation) was the control.  The results of experimental research proved that the method of laying drip irrigation pipelines had a direct effect on the parameters of the formation of drip irrigation regimes and the productivity of sunflower hybrids in the conditions of the Dry Steppe. The mechanism of evapotranspiration formation of sunflower crops in irrigated and non-irrigated conditions has been determined. It was statistically proven that the application of subsoil drip irrigation with the laying of irrigation pipelines at a depth of 0.3 m and a distance between them of 1.0 m is the most appropriate for growing sunflower hybrids. This is explained by biological features, namely drought resistance of this crop. Thus, in field experiments, the variant with in-soil laying of drip irrigation pipelines provided almost identical yield (4.01-4.09 t/ha) when having lower crop water consumption coefficients (1088.7-1125.7 m3/t) and higher efficiency of irrigation water use – 2.27-2.41 kg of grain per 1 m3 of irrigation water.
Understanding Childhood Victimization Experiences and Mental Health Outcomes in a Sample of Prison Inmates in Northern Chile
Authors: Pinto-Cortez Cristián , Portilla-Saavedra Diego , Arias Diego , Ferrer-Urbina Rodrigo , Rojas Marjorie , Carvajal Javiera , Zamora Álvaro , Suárez-Soto Elizabeth
Published: August 2023

Previous research has demonstrated a relationship between childhood victimization and negative mental health outcomes among individuals deprived of liberty. However, these studies have generally focused on

physical abuse or sexual abuse and have been conducted in developed countries. Based on this background, the present study aimed to explore the associations between different forms of childhood victimization and psychological distress in a sample of individuals deprived of liberty in

northern Chile. Data from 229 participants in a high-security prison facility were used. Six modules of

victimization were included, such as conventional crimes, caregiver victimization, peer victimization, sexual

victimization, and indirect victimization. Correlation analyses and multiple hierarchical regression were conducted to measure the associations between the variables of interest and psychological distress.

Overall, different forms of victimization were associated with all evaluated symptomatology. In a more detailed analysis, it was found that gender, caregiver victimization, and sexual victimization had the greatest predictive weight on adult mental health problems among individuals deprived of liberty. From a social reintegration perspective,

these findings could provide the necessary theoretical basis for increased investment in mental health for the incarcerated population in Chile.

Considering that many of these individuals may have been exposed to experiences of victimization in their childhood, it becomes crucial to prioritize their mental well-being as part of their rehabilitation process. It is necessary to continue deepening the understanding of these

phenomena through studies considering the high prevalence of mental health problems among individuals in correctional systems.
A Generalized Multi-Detectors Combination Approach for Differential Item Functioning Detection.docx
Authors: HUANG Shan , Ishii Hidetoki
Published: August 2023

 

To achieve more accurate and robust Differential Item Functioning (DIF) detection, this study introduces a novel approach called Multi-Detectors Combination (MDC). The main innovation of the MDC approach lies in effectively integrating multiple existing single DIF detection methods under observable examination conditions. Four specific supervised learning methods (LR, NB, TAN, and SVM) in MDC are evaluated using simulated data (360 testing conditions). The results indicate that MDC methods outperform single DIF detection in accuracy (AUC: 81.2% to 82.3%), surpassing the AUC values of other methods, which ranged only from 59.4% to 77.4%. Among MDC methods, TAN performed the best, under all observable test conditions. Moreover, MDC methods demonstrate enhanced precision (RMSE: 0.528 to 0.531) in ability estimation. Analysis of actual data further validates the MDC approach's superior stability in ability estimation, achieved by excluding flagged DIF items.
SULT1B1 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that sulfotransferase family 1B member 1, encoded by SULT1B1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. SULT1B1 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of SULT1B1 in primary tumors was correlated with patient distant metastasis-free and recurrence-free survival. Modulation of SULT1B1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
ACCURACY OF AB INITIO TECHNIQUE IN PREDICTING THE STRUCTURAL, ELECTRONIC, MECHANICAL AND ELASTIC PROPERTIES OF RHODIUM AND RUTHENIUM.
Authors: Enaroseha Omamoke O. E. , Agbajor Godwin K. , Oyibo Obed , Oyebola Olusola
Published: August 2023

The structural, thermodynamics, electronics and mechanical properties of Rhodium andapproximately 1.6% for Ru and 1.9% for Rh. The bulk moduli agree with other reported resultsRuthenium transition metals are analyzed using the first principle calculations in this research.depending on the direction of its covalent bonding while Rh withstand breaking during band three fold, two fold degenerate. And non degenerate levels are represented by the compared to Rh in terms of its elastic characteristics and more prone to modify its properties GGA to treat the exchange – correlation function with the PBE functional are mechanically stable as they agreed excellently with the results discussed in the literature. The experimental development compared to Ru because of its anisotropy’s greater deviation from parameters for Rh and Ru respectively are C44 is 2.0 and 221, C11 – C12 is 0.19 and 238, and 2C11– 2C12 is8.74 and 1376. The results also indicate that Ru exhibits anisotropic tendencies package where the elemental structures were obtained and the PAW pseudo potentials andreported in the literature. The outcome of this investigation shows that the examined elementsThe results for the lattice parameters deviated from experimental and theoretical results withWe adopted the DFT with the solution pf Kohn Sham equation given and using the Xcrydenunity, hence, this is accurately given that it’s also stiffer and tougher.
H4C14 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that H4 clustered histone 14, encoded by H4C14, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. H4C14 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of H4C14 in primary tumors was correlated with patient distant metastasis-free survival. Modulation of H4C14 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
ADPRS is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ADP-ribosylserine hydrolase, encoded by ADPRS, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ADPRS mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of ADPRS in primary tumors was correlated with patient survival outcomes. Modulation of ADPRS expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Carbon emissions associated with end-of-life care in the hospital setting: a paradigm shift for people and our planet
Authors: Sergeant Myles D , Ly Olivia , Kandasamy Sujane , Anand Sonia S , de Souza Russell
Published: August 2023

Healthcare contributes significantly to global warming and accounts for 4.4% of global greenhouse gas emissions. Additionally, the end-of-life (EOL) period is characterized by disproportionately high hospital use, which is both emissions-intensive and often contrary to patients’ wishes to receive EOL care at home. In Canada, end-of-life hospitalization accounts for almost 6 million hospital days and about 263,500 tCO2-e annually. By engaging in advance care planning, improving access to community palliation, and supporting care in alternative settings, we estimate that 25% of EOL hospitalization emissions can be avoided.
Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: Results from the AURORA study
Authors: Haering Stephanie , Seligowski Antonia V. , Linnstaedt Sarah D. , Michopoulos Vasiliki , House Stacey L. , Beaudoin Francesca , An Xinming , Neylan Thomas C. , Clifford Gari D. , Germine Laura T. , Rauch Scott L. , Haran John P. , Storrow Alan B. , Lewandowski Christopher , Musey Paul I. , Hendry Phyllis L. , Sheikh Sophia , Jones Christopher W. , Punches Brittany E. , Swor Robert A. , Gentile Nina T. , Hudak Lauren A. , Pascual Jose L. , Seamon Mark S. , Pearson Claire , Peak David A. , Merchant Roland C. , Domeier Robert M. , Rathlev Niels K. , O'Neil Brian J. , Sanchez Leon D. , Bruce Steven E. , Harte Steven E. , McLean Samuel A. , Kessler Ronald C , Koenen Karestan C. , Stevens Jennifer S. , Powers Abigail
Published: August 2023

Importance: Knowledge of sex-differences in risk factors for posttraumatic stress disorder (PTSD) can contribute to the development of refined preventive interventions.Objective: To examine sex-dependent vulnerability to PTSD risk factors.Design: The Advancing Understanding of Recovery After TraumA (AURORA) study was a prospective cohort study that followed participants for 12 months after acute trauma exposure. Data for this report was collected from September 2017 through June 2021 and includes self-report information from baseline, 2-week, 8-week, and 3-month follow-up. Data analysis was performed from October 19, 2022 to January 31, 2023.Setting: Multicenter study conducted in 29 US emergency departments (ED).Participants: Adult patients presenting to EDs within 72 hours of acute trauma.Exposure: Acute trauma Main Outcome and Measures: Self-reported PTSD severity 3 months post-trauma as assessed with the PTSD Checklist for DSM-5.Results: A total of 2942 participants (62% women; mean age 35.9 (SD 13.3) years) were included. Women reported higher PTSD severity at 3-months post-trauma (d = .24, p<.001). Z-score comparisons indicated that for five of the 16 examined risk factors the association with 3-month PTSD severity was stronger in men than in women. In multivariable models, interaction effects with sex were observed for pre-traumatic anxiety symptoms (ß = -0.11, p<.005), and acute dissociative symptoms (ß = -0.10, p<.005); both showed stronger associations with PTSD in men than in women.Conclusions and Relevance: We conducted a comprehensive analysis of sex-dependent vulnerability to early PTSD risk factors in a large cohort of acutely traumatized individuals. Despite women’s higher PTSD severity at 3-month post-trauma, analyses did not identify any risk factors to which women were more vulnerable than men. This points towards the consideration of further mechanisms to explain women’s higher PTSD risk. Our findings further indicate mechanisms to which men might be particularly vulnerable, demonstrating that known PTSD risk factors might behave differently in women and men. Our study illustrates the need for a more systematic examination of sex differences in contributors to PTSD severity after trauma, which may inform refined preventive interventions.
Laminar dissociation of feedforward and feedback signals in high-level ventral visual cortex during imagery and perception
Authors: Carricarte Tony , Iamshchinina Polina , Trampel Robert , Chaimow Denis , Weiskopf Nikolaus , Cichy Radoslaw M.
Published: August 2023

Visual imagery and veridical perception are phenomenologically related, suggesting that they share neural machinery. Previous research confirmed this assumption at the macroscale of human cortical organization in category-selective regions in ventral visual cortex. However, imagery and perception differ fundamentally in the information flow that underlies them: perception is driven by the integration of sensory feedforward and internally-generated feedback information, whereas imagery depends on feedback only. This suggests that while visual imagery and perception may activate common cortical regions, they do so in fundamentally distinctive ways. To investigate, we resolved neural activity during imagery and perception in the ventral visual cortex at the level of laminar organization that anatomically and functionally distinguishes feedforward from feedback information flow. We found distinctive laminar profiles for imagery and perception of scenes and faces in parahippocampal place area (PPA) and fusiform face area (FFA) respectively. Our findings clarify the neural basis of the phenomenology of visual imagery versus perception, and shed new light on how feedforward and feedback information processing in high-level ventral visual cortex orchestrates human object vision.
Conceptions and Perceptions of Psychotherapy in the Eyes of Therapists and their Patients: Longitudinal Analysis by the Faceted Action System Theory (FAST)
Authors: Shye Samuel
Published: August 2023

In this extensive longitudinal study, a total of 54 pairs comprising therapists and patients underwent thorough interviews throughout the course of their therapeutic journey. The interviews were designed to explore two primary aspects: (a) participants' fundamental understanding of psychotherapy, and (b) Participants' perception of the therapy in which they were engaged. Both therapists and patients completed comprehensive questionnaires at three distinct time points: prior to the commencement of therapy, as well as two months and eight months into the therapeutic process. Conceiving the therapeutic process as a Faceted Action System (FAST; Shye 1985; 2014a), the study categorized observable variables into four distinct functioning modes: conservative, integrative, adaptive, and expressive. These modes corresponded to different aspects of the therapist-patient dynamic: the implied contract between them, their interactive exchanges, the management of external factors, and the ultimate therapy outcome—measured as enhancements in the patient's Systemic Quality of Life (SQOL, as defined by Shye in 1989 and 2014(.Following the initial confirmation of therapy's effectiveness in the observed cases, the study delved into the dynamics between therapists and patients. This exploration utilized Faceted Smallest Space Analysis (FSSA), a variant of Multidimensional Scaling (MDS) that incorporates content analysis. FSSA visually mapped out the structure and progression of therapy of both, the way it was conceived and the way it was perceived by the therapy partners.The findings illuminated an intriguing evolution over time. Therapists' conceptual maps of therapy shifted away from the conventional "classic" systemic pattern—initially adhering to FAST's axioms—towards a viewpoint more aligned with that of the patients. Notably, variables associated with "active integrative" elements, such as diverse therapist interventions, transitioned towards the adaptive mode region. As therapy extended to eight months, patients' conceptualization diverged significantly from the classic systemic structure. Instead, it adopted a novel pattern characterized by heightened differentiation within the integrative mode, encompassing both active and passive forms. This underscored the profound significance patients attributed to the patient-therapist relationship.
When to Keep Trying and When to Let Go: Benchmarking Optimal Quitting
Authors: Sukhov Nikolay , Dubey Rachit , Duke Annie , Griffiths Tom
Published: August 2023

Persistence and perseverance, even in the face of great adversity, are admirable qualities. However, knowing when to stop pursuing something is as important as exerting effort toward attaining a goal. Howdo people decide when to persist and when to quit? Here, we design a novel task to study this question, in which people were given a finite number of opportunities to pursue stochastic rewards by selecting among a set of options that provide a reward each trial. At any time, if people were not satisfied with the option they had selected they could choose to abandon it and instead try a new option. However, if they did so they could never return to the previous option. Mathematical analysis of this task shows that the optimal strategy explores a relatively small number of options before settling on a sufficiently good option. Further, we find that the optimal strategy is to abandon an option if the total number of remaining trials exceeds a threshold specified by the observed option’s performance. A large-scale, pre-registered experiment (N = 3,632) reveals that people largely behave in accordance with the optimal strategy. People also make decisions to persist with an option based on its performance and they typically explore relatively few options before settling on a sufficiently good one. However, compared to the optimal strategy, people are less sensitive to the number of remaining trials and are more likely to persist with sub-optimal options. Together, this work provides a new approach to studying how we decide when to quit and deepens our understanding of human persistence.
A daily diary study on associations between school-based ethnic discrimination and school engagement
Authors: Civitillo Sauro , Jugert Philipp , Tiffany Yip Wing Lam , Lui P. Priscilla , Titzmann Peter
Published: August 2023

Being the target of discriminatory actions due to ethnicity can lead ethnic minority students to disengage from school. Yet research on the links between school-based ethnic discrimination and school engagement has mostly examined between-person level associations, which limits our understanding of within-person dynamic fluctuations. The current study assessed how different types (i.e., overt- vs. subtle behavior) and sources (i.e., peer vs. teacher) of school-based ethnic discrimination are linked to behavioral, emotional, and cognitive school engagement at the same- and next-day levels. Participants were secondary school students of Turkish and Arab descent (N = 87, Mage = 15, 62% female) in an ethnically diverse area of north-west Germany. Using an interval-contingent design, participants completed a daily diary once a day over a two week-period using a smartphone application. At the within-person level, multilevel models indicated that discrimination by teachers was negatively related to same-day cognitive engagement and next-day emotional engagement. We found little evidence for within-person links between any discrimination types and sources and behavioral school engagement. This study documents the negative consequences of experiencing school-based ethnic discrimination on student school engagement.
Independents, not partisans, are more likely to hold and express electoral preferences based in negativity
Authors: Siev Joseph , Rovenpor Daniel , Petty Richard
Published: August 2023

The contemporary political domain is characterized by widespread negativity. Much of this negativity is thought to be generated by strong partisans, who overall express more anger, animosity, and bias than weaker partisans. The present research proposes, however, that self-categorized political independents hold preferences based more in negativity than partisans do, making them more likely to frame their preference in oppositional terms, act on the basis of opposition (vs. support), and agree with opposition- (vs. support-) based messages. Five studies (N=51,687) present evidence of this valenced pattern of independent-partisan differences. In Study 1, across five decades, U.S. independents’ (vs. partisans’) preferences were more reflective of negative (vs. positive) partisanship. In Study 2, across four presidential elections, a greater proportion of independents than partisans reported voting “against” (vs. “for”) a candidate. In Study 3, negative (vs. positive) attitudes better predicted independents’ participatory behaviors relative to those of partisans. In Study 4, independents agreed more with negatively-framed (vs. positively-framed) political appeals, whereas the opposite was true of partisans. Independents’ (vs. partisans’) preferences were more negative before the current politically polarized era and their proportional increase reflects a broader shift toward negative preferences. Finally, Study 5 replicated Studies 1-2 in three non-political domains, including one where attitudes were positive overall. Implications are discussed for the relationship between partisanship and negativity, how independents differ psychologically from partisans, partisanship as a moderator of preference valence-framing effects, and the possibility of general dispositional tendencies to base, frame, and express one’s political and non-political preferences negatively.
Determinants of Non-Performing Loans of Public Commercial Banks
Authors: Srijana Khadka  , Ajaya Kumar Khadka
Published: August 2023

The study aimed to examine the effect of profitability on non-performing loans of the Nepalese Commercial Banks. To meet the study’s objectives, three public commercial banks' non-performing loans (NPL) were analyzed using a research methodology that included descriptive and causal comparison methods. The study used a purposive sampling design to select three public commercial banks from 21 populations and used secondary data for the fiscal years 2012/13 to 2021/22. As an alternative data collection technique, the study has 30 observations from the population. This research indicates that remittance and return on equity are significantly associated with non-performing loans. Likewise, remittances negatively influence the NPL of public banks in Nepal, whereas ROE has a favorable effect. NPL was unaffected by GDP, inflation, or ROA to any substantial degree. Researching foreign direct investment and the balance of payments is recommended. Financial institutions should refrain from distributing further credit if they operate under a higher NPL.
Trading Volume, Trading Price, Trading frequency and Stock Return Volatility of Everest Bank Limited
Authors: Bashu Neupane  , Dipendra Neupane  , Puskar Baral
Published: August 2023

The primary objective of this study is to measure the relationship between stock returns, trading volume, trading frequency and trading price volatility of Everest Bank Limited. We analyzed studies using descriptive studies and randomized comparative studies. A 12-year panel data set was used. 1873 observations are analyzed to draw correct conclusions about the study. Descriptive models provide data on average stock returns, trading volume, and price volatility. EBL investors have faced high risk when investing in stocks for 12 years. There is an important and positive relationship between them. Likewise, volume and price have a positive and significant impact on stock returns.
The Role of Financial Ratios in Predicting Return on Equity of Commercial Banks
Authors: Shiva Raj Poudel  , Subhadra Dahal  , Rishikesh Panthi
Published: August 2023

The explanatory power of the bank specific financial ratios on return on equity of the joint venture commercial banks operated in Nepal has been examined by using the database of 15 years from 2005/06 to 2019/20. The descriptive and correlational research design have been adopted for the study. The explanatory financial ratios used for the study includes capital adequacy, non-performing loan to total loan, net interest to total assets ratio, deposit to total assets ratio, and investment to total assets ratio. Statistical tools such as descriptive statistics, correlation analysis, and the regression analysis have been used as the major tools of data analysis. The results revealed that capital adequacy ratio, net interest to assets ratio and investment to assets ratio have the significant positive impact on commercial banks profitability. In contrast, non-preforming loan to total loan has the significant negative impact on banks' profitability whereas, deposit to total assets ratio has no significant impact on commercial banks' profitability.