bluuebunny/crossref_metadata_2025 huggingface dataset:
Precious metal clusters as fundamental agents in bioimaging usability
Authors: He Xiaoxiao , Liu Shaojun , Hu Xi , Huang Xiongyi , Zhang Hehua , Mao Xiang
Published: November 2023

Fluorescent nanomaterials (NMs) are widely used in imaging techniques in biomedical research. Especially in bioimaging systems, with the rapid development of imaging nanotechnology, precious metal clusters such as Au, Ag, and Cu NMs have emerged with different functional agents for biomedical applications. Compared with traditional fluorescent molecules, precious metal clusters have the advantages of high optical stability, easy regulation of shape and size, and multifunctionalization. In addition, NMs possess strong photoluminescent properties with good photostability, high release rate, and sub-nanometer size. They could be treated as fundamental agents in bioimaging usability. This review summarizes the recent advances in bioimaging utilization, it conveys that metal clusters refer to Au, Ag, and Cu fluorescent clusters and could provide a generalized overview of their full applications. It includes optical property measurement, precious metal clusters in bioimaging systems, and a rare earth element-doped heterogeneous structure illustrated in biomedical imaging with specific examples, that provide new and innovative ideas for fluorescent NMs in the field of bioimaging usability.
Utilizing the intelligent sensing function of conjugated materials to create intelligent flute training equipment
Authors: Lu Jialiang
Published: November 2023

The manufacturing of flutes has always relied on traditional ceramics and metals, which may be affected by various factors during the manufacturing process, as well as the lack of intelligent sensing functions, resulting in poor sound quality and performance of the instrument. The purpose of this article is to explore the use of the intelligent sensing function of conjugated materials to create intelligent flute training equipment, achieve automatic tuning, volume control, etc., and improve the playing experience and training effect of the instrument. This article first analyzes the smart sensing function of conjugate materials and applies it to smart flute training equipment; then, introduces photosensitive materials at appropriate locations to change the size and shape of the flute’s sound hole, thereby adjusting the timbre; finally, uses smart flute training based on conjugate materials for real-time perception of performers’ performance experiments. The test results show that the average delay time of the conjugate material trench is reduced by 73.1% compared with the average delay time of the ceramic trench, and is reduced by 63.5% compared with the average delay time of the metal trench. This shows that the conjugated material flute is more intelligent and can quickly respond to the player’s performance and automatically control and respond.
Improving persistence of underrepresented racial minority science majors: where to begin
Authors: Oyelaran Oyindasola
Published: November 2023

Many colleges and universities are interested in implementing effective strategies to support broaden participation and persistence of undergraduates, and especially underrepresented students, in Science, Technology, Engineering, and Mathematics (STEM) majors. While there are programs and models that have proven successful in this arena, many of these models are extremely resource intensive. This Perspective provides a distillation of key aspects of successful programs that institutions could consider implementing as a starting point when thinking about how to design programs to support students in STEM.
Experimental study of a linear Fresnel reflection solar concentrating system
Authors: Zhang Qian , Chen Song , Yuan Bin , Huang Lei
Published: November 2023

Introduction: In the field of solar energy utilization, the construction of low cost and easy to process large concentrated photothermal system is a scientific problem to be solved. A linear Fresnel reflection solar concentrator is proposed in this paper.

Methods: The position, tilt angle and width of the glass mirrors placed in the same plane are different to ensure that all the reflected light falls on the flat focal plane or cylindrical focal surface. According to the focusing principle of the concentrator, two experimental system platforms ware built. When a flat focal plane is used to receive radiation from the sun, the intensity distribution of focal plane light spot is uniform in theory.

Results: The CCD measurement method is used to analyze the concentrated light spot under experimental conditions, and it is proved that the energy flux density on the focal plane is uniform. Placing monocrystalline silicon cells on the focal plane, the experimental results of p-v power generation voltammetry show that the power generation efficiency of monocrystalline silicon cell does not decrease due to the uniform solar energy density, which can reach 17.1%. The photothermal experiment is carried out by using one-dimensional tracking mode of sunlight. The concentrator reflects the sun’s rays onto the vacuum collector tubes, heating the heat conduction oil flow in. The thermocouple measures the temperature of the heat conduction oil at the inlet and outlet of the vacuum collector tubes. The experimental photothermal conversion efficiency of this concentrator was analyzed and calculated through multiple groups of photothermal experiments, and compared with the theoretical concentrator efficiency. With two collector tubes in series, the theoretical photothermal conversion efficiency reaches 0.8 and the experimental photothermal conversion efficiency reaches about 0.74.

Discussion: Because of its good concentrating performance and low cost, this type concentrator can be widely used in photothermal and photovoltaic applications.
Advancements and prospects of CRISPR/Cas9 technologies for abiotic and biotic stresses in sugar beet
Authors: Misra Varucha , Mall A. K. , Pandey Himanshu , Srivastava Santeshwari , Sharma Avinash
Published: November 2023

Sugar beet is a crop with high sucrose content, known for sugar production and recently being considered as an emerging raw material for bioethanol production. This crop is also utilized as cattle feed, mainly when animal green fodder is scarce. Bioethanol and hydrogen gas production from this crop is an essential source of clean energy. Environmental stresses (abiotic/biotic) severely affect the productivity of this crop. Over the past few decades, the molecular mechanisms of biotic and abiotic stress responses in sugar beet have been investigated using next-generation sequencing, gene editing/silencing, and over-expression approaches. This information can be efficiently utilized through CRISPR/Cas 9 technology to mitigate the effects of abiotic and biotic stresses in sugar beet cultivation. This review highlights the potential use of CRISPR/Cas 9 technology for abiotic and biotic stress management in sugar beet. Beet genes known to be involved in response to alkaline, cold, and heavy metal stresses can be precisely modified via CRISPR/Cas 9 technology for enhancing sugar beet’s resilience to abiotic stresses with minimal off-target effects. Similarly, CRISPR/Cas 9 technology can help generate insect-resistant sugar beet varieties by targeting susceptibility-related genes, whereas incorporating Cry1Ab and Cry1C genes may provide defense against lepidopteron insects. Overall, CRISPR/Cas 9 technology may help enhance sugar beet’s adaptability to challenging environments, ensuring sustainable, high-yield production.
Possibilistic distribution distance metric: a robust domain adaptation learning method
Authors: Tao Jianwen , Dan Yufang , Zhou Di
Published: November 2023

The affective Brain-Computer Interface (aBCI) systems, which achieve predictions for individual subjects through training on multiple subjects, often cannot achieve satisfactory results due to the differences in Electroencephalogram (EEG) patterns between subjects. One tried to use Subject-specific classifiers, but there was a lack of sufficient labeled data. To solve this problem, Domain Adaptation (DA) has recently received widespread attention in the field of EEG-based emotion recognition. Domain adaptation (DA) learning aims to solve the problem of inconsistent distributions between training and test datasets and has received extensive attention. Most existing methods use Maximum Mean Discrepancy (MMD) or its variants to minimize the problem of domain distribution inconsistency. However, noisy data in the domain can lead to significant drift in domain means, which can affect the adaptability performance of learning methods based on MMD and its variants to some extent. Therefore, we propose a robust domain adaptation learning method with possibilistic distribution distance measure. Firstly, the traditional MMD criterion is transformed into a novel possibilistic clustering model to weaken the influence of noisy data, thereby constructing a robust possibilistic distribution distance metric (P-DDM) criterion. Then the robust effectiveness of domain distribution alignment is further improved by a fuzzy entropy regularization term. The proposed P-DDM is in theory proved which be an upper bound of the traditional distribution distance measure method MMD criterion under certain conditions. Therefore, minimizing P-DDM can effectively optimize the MMD objective. Secondly, based on the P-DDM criterion, a robust domain adaptation classifier based on P-DDM (C-PDDM) is proposed, which adopts the Laplacian matrix to preserve the geometric consistency of instances in the source domain and target domain for improving the label propagation performance. At the same time, by maximizing the use of source domain discriminative information to minimize domain discrimination error, the generalization performance of the learning model is further improved. Finally, a large number of experiments and analyses on multiple EEG datasets (i.e., SEED and SEED-IV) show that the proposed method has superior or comparable robustness performance (i.e., has increased by around 10%) in most cases.
Learnable axonal delay in spiking neural networks improves spoken word recognition
Authors: Sun Pengfei , Chua Yansong , Devos Paul , Botteldooren Dick
Published: November 2023

Spiking neural networks (SNNs), which are composed of biologically plausible spiking neurons, and combined with bio-physically realistic auditory periphery models, offer a means to explore and understand human auditory processing-especially in tasks where precise timing is essential. However, because of the inherent temporal complexity in spike sequences, the performance of SNNs has remained less competitive compared to artificial neural networks (ANNs). To tackle this challenge, a fundamental research topic is the configuration of spike-timing and the exploration of more intricate architectures. In this work, we demonstrate a learnable axonal delay combined with local skip-connections yields state-of-the-art performance on challenging benchmarks for spoken word recognition. Additionally, we introduce an auxiliary loss term to further enhance accuracy and stability. Experiments on the neuromorphic speech benchmark datasets, NTIDIDIGITS and SHD, show improvements in performance when incorporating our delay module in comparison to vanilla feedforward SNNs. Specifically, with the integration of our delay module, the performance on NTIDIDIGITS and SHD improves by 14% and 18%, respectively. When paired with local skip-connections and the auxiliary loss, our approach surpasses both recurrent and convolutional neural networks, yet uses 10 × fewer parameters for NTIDIDIGITS and 7 × fewer for SHD.
Prefrontal cortex functional connectivity changes during verbal fluency test in adults with short-term insomnia disorder: a functional near-infrared spectroscopy study
Authors: Wu Peirong , Wang Chaowen , Wei Mindong , Li Yijiang , Xue Yuan , Li Xinrong , Jiang Jianfan , Bi Yinuo , Dai Jian , Jiang Wenyu
Published: November 2023

Background

Individuals suffering from short-term insomnia disorder (SID) experience difficulties in falling or staying asleep, often leading to daytime fatigue and impaired concentration. However, the underlying mechanisms of SID remain unclear. This study aims to investigate the alterations in brain activation patterns and functional connectivity in patients with SID.

Methods

The study enrolled a total of 31 adults diagnosed with SID and 31 healthy controls (HC). Functional near-infrared spectroscopy (fNIRS) was utilized to assess the concentrations of oxyhemoglobin (Oxy-Hb) and functional connectivity in the prefrontal cortex of each participant while performing the verbal fluency test (VFT) task.

Results

In the VFT task, no significant difference was found between the SID group and the HC group in terms of integral values, centroid values, and mean Oxy-Hb variations. These findings suggest that both groups exhibit similar hemodynamic responses. However, the functional connectivity analysis revealed significant differences in inter-channel connectivity strength between the two groups. The SID group showed significantly lower average inter-channel connectivity strength compared to the HC group. Moreover, six channel pairs (right frontopolar cortex – left frontopolar cortex, left orbitofrontal cortex – left temporopolar cortex, left temporopolar cortex – left frontopolar cortex, left frontopolar cortex-Ch38, left frontopolar cortex – right pre-motor and supplementary motor cortex, and left frontopolar cortex – right dorsolateral prefrontal cortex) exhibited significantly higher connectivity strength in the HC group compared to the SID group (FDR corrected, p < 0.05). Specifically, channel 27 exhibited the highest frequency of significant connectivity across different channel pairs, occurring five times in total. The channel pair Ch27-Ch39, representing left frontopolar cortex and right dorsolateral prefrontal cortex, exhibited a negative correlation with PSQI scores (r = −0.422, p = 0.018).

Conclusion

Our findings suggest that patients with SID may exhibit altered brain connectivity during the VFT task, as measured by fNIRS. These results provide valuable insights into the functional brain differences associated with SID. Further research is needed to validate and expand upon these findings.
The effects of Src tyrosine kinase inhibitor, saracatinib, on the markers of epileptogenesis in a mixed-sex cohort of adult rats in the kainic acid model of epilepsy
Authors: Rao Nikhil S. , Putra Marson , Meyer Christina , Almanza Aida , Thippeswamy Thimmasettappa
Published: November 2023

Neurodegeneration and neuroinflammation are key processes of epileptogenesis in temporal lobe epilepsy (TLE). A considerable number (∼30%) of patients with epilepsy are resistant to currently available antiseizure drugs and thus there is a need to develop adjunct therapies to modify disease progression. A vast majority of interventional strategies to treat TLE have utilized males which limits the translational nature of the studies. In this study, we investigated the effects of repeated low-dose kainic acid (KA) injection on the initial status epilepticus (SE) and the effects of Src kinase inhibitor, saracatinib (SAR/AZD0530; 20 mg/kg, oral, daily for 7 days), in a mixed-sex cohort of adult Sprague Dawley rats during early epileptogenesis. There were no sex differences in response to KA-induced SE, and neither did the stage of estrus influence SE severity. KA-induced SE caused significant astrogliosis and microgliosis across the hippocampus, piriform cortex, and amygdala. SAR treatment resulted in a significant reduction of microgliosis across brain regions. Microglial morphometrics such as branch length and the endpoints strongly correlated with CD68 expression in the vehicle-treated group but not in the SAR-treated group, indicating mitigation by SAR. KA-induced SE caused significant neuronal loss, including parvalbumin-positive inhibitory neurons, in both vehicle (VEH) and SAR-treated groups. SAR treatment significantly mitigated FJB-positive neuronal counts as compared to the VEH group. There was an increase in C3-positive reactive astrocytes in the VEH-treated group, and SAR treatment significantly reduced the increase in the piriform cortex. C3-positive astrogliosis significantly correlated with CD68 expression in the amygdala (AMY) of VEH-treated rats, and SAR treatment mitigated this relationship. There was a significant increase of pSrc(Y419)-positive microglia in both KA-treated groups with a statistically insignificant reduction by SAR. KA-induced SE caused the development of classical glial scars in the piriform cortex (PIR) in both KA-treated groups, while SAR treatment led to a 42.17% reduction in the size of glial scars. We did not observe sex differences in any of the parameters in this study. SAR, at the dose tested in the rat kainate model for a week in this study mitigated some of the markers of epileptogenesis in both sexes.
Definition of malnutrition from routinely-collected data for orthopedic surgery research: the global leadership initiative on malnutrition (GLIM) tool and others
Authors: Briguglio Matteo , Wainwright Thomas W. , Lombardi Giovanni
Published: November 2023

The correct identification of malnourished patients in the context of hip, knee, or spine surgery research would enhance the quality of analytical studies investigating the prediction potential of preoperative nutritional disorders on postoperative recovery. However, accurate malnutrition screening and diagnostic assessment rely on parameters that were not routinely collected in routine practice until a few years ago. The authors of this article present substitute literature-based equations that can be built up using historical routinely collected data to classify patients that had been at risk of malnutrition or malnourished. For what concerns the risk screening, several methods are available to identify patients at risk of over- or undernutrition, encompassing the BWd (body weight difference from the ideal weight), GNRI (geriatric nutritional risk index), INA (instant nutritional assessment), LxA (combination of lymphocyte count and albumin), PMA (protein malnutrition with acute inflammation), PMAC (protein malnutrition with acute and chronic inflammation), IDM (iron deficit malnutrition), and VBD (vitamin B deficit malnutrition). Conversely, the GLIM (global leadership initiative on malnutrition) criteria can be used to assess malnutrition and diagnose subclasses of undernutrition. Rational use of these tools can facilitate the conduction of efficient prospective studies in the future, as well as bespoke retrospective cohort studies and database research.
Macronutrient intake and alertness during night shifts – the time interval matters
Authors: de Rijk Mariëlle G. , van Eekelen Alexander P. J. , Boesveldt Sanne , Kaldenberg Elly , Holwerda Tineke , Lansink Ceciel J. M. , Feskens Edith J. M. , de Vries Jeanne H. M.
Published: November 2023

Background

Working night shifts is associated with higher safety risks due to shift work-related fatigue. Nutrition, especially certain (macro) nutrient compositions, has been suggested to reduce fatigue, however, results of studies are contradictory. This could be explained by differences in the time interval investigated between the consumption of a meal and measurement of cognitive performance. Therefore, this observational study investigated the association between macronutrient intake and objective alertness at different time intervals during the night shift in nurses.

Methods

128 nurses, aged 20–61 years, completed an alertness test (Psychomotor Vigilance Task) during the night shift and a 24-h dietary recall after the night shift. This was repeated three times, always on the first night shift in a night shift series. The associations between macronutrient intake 0 to 1, 1 to 2, and 2 to 3 h before the PVT with alertness during the night shift were analyzed through Linear Mixed Models. The basic model was adjusted for age and gender and the adjusted model additionally for BMI, start time of PVT and energy and caffeine intake during the relevant time interval.

Results

Protein intake was not associated with objective alertness levels, while fat and carbohydrates intake had opposite associations with objective alertness levels over similar time intervals. Fat intake up to 1 h prior to the PVT was borderline associated with a longer median reaction time (RT) (ß = 9.00 ms/10 g fat, 95% CI: −0.21, 18.20), while a higher carbohydrate intake up to 1 h prior to the PVT was borderline associated with shorter median RTs (ß = −3.89, 95% CI: −7.85, 0.06). A higher fat intake 2 to 3 h prior to the PVT was associated with less lapses (log transformed ß = −0.16; 95% CI: −0.31, −0.02), while a higher carbohydrate intake 2 to 3 h prior to the PVT was associated with more lapses (ß = 0.06, 95% CI: 0.01, 0.12).

Conclusion

Our results contribute to understanding the association between macronutrient intake, as part of a mixed meal, and alertness levels. Conflicting results from previous studies may probably be due to time differences between macronutrient intake and alertness testing.
Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects
Authors: Li Chunmei , Zhou Yu , Yuan Meng , Yang Yawen , Song Ruilong , Xu Gang , Chen Gang
Published: November 2023

Introduction

Astaxanthin (AST) is a type of carotenoid with strong antioxidant effects. However, the development and use of AST are limited by its water insolubility and low bioavailability. This study aims to investigate whether AST@PLGA can inhibit UC and reveal its possible mechanism.

Methods

We tested the particle size, polydispersity index, and zeta potential of AST@PLGA. Then, the in vitro release and antioxidant capacity of AST@PLGA were tested. Finally, the mouse model of colitis was established and SOD, MDA, TNF-α, IL-1β, IL-6 and P38 as well as ERK were detected from mice.

Results

Particle size, polydispersity index and zeta potential of AST @PLGA were 66.78 ± 0.64 nm, 0.247 and -9.8 ± 0.53 mV, respectively, and were stable within 14 days. Then, it was observed that the AST@PLGA nanoparticles not only maintained the effect of AST but also had a sustained release effect. Experiments in mice showed that AST@PLGA effectively reduced MDA, TNF-α, IL-1β and IL-6 levels and increased SOD levels. AST@PLGA also downregulated the protein expression of P38 and ERK. The results showed the positive protective effect of AST@PLGA in inhibiting acute colitis.

Discussion

AST@PLGA nanoparticles have good stability and alleviating effect in colitis, which could be functional foods in the future.
Case Report: Solid variant of papillary thyroid carcinoma in a young adult with Turner syndrome with chronic thyroiditis
Authors: Murakami Daichi , Hijiya Masayoshi , Iyo Takuro , Hayata Sachiko , Ozaki Takashi , Enomoto Keisuke , Kono Masamitsu , Tamagawa Shunji , Hotomi Muneki
Published: November 2023

Turner syndrome is associated with an increased risk of developing several neoplasms. In particular, a clinical feature of Turner syndrome with chronic thyroiditis implies a relationship with thyroid malignancies. We report a very rare case of a solid variant of papillary thyroid carcinoma that was identified during a follow-up of chronic thyroiditis in a 22-year-old woman with Turner syndrome. The patient had no notable history of radiation exposure. No genetic mutations relating to the occurrence of the solid variant of papillary thyroid carcinoma, including RET/PTC rearrangements and mutations in the BRAF or RAS, were detected by a gene panel test, namely, the Oncomine™ Dx Target test. To the best of our knowledge, this is the first report of a solid variant of papillary thyroid carcinoma in a young adult with Turner syndrome with chronic thyroiditis. Our case suggests that in patients with Turner syndrome, there may be different pathogeneses from those previously reported, including exposure to radiation or known genetic mutations for the development of a solid variant of papillary thyroid carcinoma.
Case report: the dissociated response and clinical benefit of primary leiomyosarcoma of the bone treated with penpulimab plus lenvatinib after failed multi-line therapy
Authors: Wang Bin , Han Yin , Liu Jie , Zhang Xinyao , Zhuo Hongyu , Jiang Yu , Deng Yaotiao
Published: November 2023

Leiomyosarcoma occurring in the bone as primary tumor localization is extremely scarce with limited cases described in the literature, accounting for less than 0.7% of all primary bone malignancies. Once distant metastasis occurs, patients have limited treatments and often a somber prognosis, which underscore the need for innovative and effective treatment approaches. The emerging evidence suggests that anti-angiogenic therapy could inhibit angiogenesis and normalize vascular permeability in the tumor microenvironment, which, in turn, would increase immune effector cell infiltration into tumors. Immunotherapy depends on the accumulation and activity of immune effector cells within the tumor microenvironment, and immune responses and vascular normalization seem to be reciprocally regulated. Immunotherapy combined with anti-angiogenic therapy has recently made great progress in the treatment of various types of tumors. However, the effectiveness of the combination treatment in metastatic leiomyosarcoma is undetermined. In this study, we presented a rare case of primary leiomyosarcoma of the bone located in the trochanteric region of the femur, accompanied by multiple distant metastases. After the failure of multi-line therapies including AI regiments as the adjuvant chemotherapy, anlotinib as the first-line therapy, GT regiment as the second-line therapy, and eribulin as the third-line therapy, the patient received combinational therapy with penpulimab plus lenvatinib. The best efficacy for this regimen was a partial response, with a progression-free survival of 8.4 months according to the iRECIST criteria. After a dissociated response was detected without severe toxicities, the patient received local radiotherapy and continued treatment on penpulimab plus lenvatinib and eventually achieved long-term survival benefits with a total of over 60 months of overall survival with good quality of life and ongoing treatment. As our previous retrospective study found that one-third of advanced STS patients could still achieve clinical benefits from rechallenge with multi-targeted tyrosine kinase inhibitors (TKIs), after the failure of previous TKI therapy, this case provided the potential clinical activity of immunotherapy combined with anti-angiogenic TKI rechallenge in metastatic leiomyosarcoma.
Protein modification regulated autophagy in Bombyx mori and Drosophila melanogaster
Authors: Wu Wenmei , Lin Luobin , Zhao Yuntao , Li Huaqin , Zhang Rongxin
Published: November 2023

Post-translational modifications refer to the chemical alterations of proteins following their biosynthesis, leading to changes in protein properties. These modifications, which encompass acetylation, phosphorylation, methylation, SUMOylation, ubiquitination, and others, are pivotal in a myriad of cellular functions. Macroautophagy, also known as autophagy, is a major degradation of intracellular components to cope with stress conditions and strictly regulated by nutrient depletion, insulin signaling, and energy production in mammals. Intriguingly, in insects, 20-hydroxyecdysone signaling predominantly stimulates the expression of most autophagy-related genes while concurrently inhibiting mTOR activity, thereby initiating autophagy. In this review, we will outline post-translational modification-regulated autophagy in insects, including Bombyx mori and Drosophila melanogaster, in brief. A more profound understanding of the biological significance of post-translational modifications in autophagy machinery not only unveils novel opportunities for autophagy intervention strategies but also illuminates their potential roles in development, cell differentiation, and the process of learning and memory processes in both insects and mammals.
Risk-taking, loss aversion, and performance feedback in dynamic and heterogeneous tournaments
Authors: Yang Qing , Zhao Yangqing
Published: November 2023

Within the context of professional football, we examined the impact of the interim game state on risk-taking and performance during a dynamic tournament. This study used 9,256 segments from the top five European football leagues as samples. These segments were derived from 1,826 games played during the 2017–2018 season. Poisson regression was employed to analyze the distinct effects of game state and heterogeneity on performance under pressure. The results indicated that stronger teams tended to increase their attack intensity when facing weaker opponents. However, as their lead expanded, they tended to reduce their attack intensity, particularly in matches with heterogeneous characteristics. Moreover, teams trailing in scores tended to intensify their attacks but achieved little. However, leading teams consistently underperformed in terms of blocked shots and corner kicks. Additionally, tied teams systematically exhibited lower performance in shots on target and free kicks compared to leading teams, despite having a higher motivation to excel. These findings extend our understanding of how risk-taking and performance depend on disclosing information regarding relative performance.
A Liver-Derived Vascular Lesion: Hepatic Hemangioma or Hepatic Epithelioid Hemangioendothelioma?
Authors: Gholami Roham , Soltani Moslem , Salarieh Naghmeh , Ketabi Moghadam Pardis
Published: November 2023

Hepatic epithelioid hemangioendothelioma (EHE) is an uncommon vascular endothelial cell tumor of the liver with numerous symptoms and features. The median affected age is 41, and females are more frequently affected than men. In the following article, a 37-year-old nurse is presented who was referred to the hospital with severe right upper quadrant pain. She had been misdiagnosed with hepatic hemangioma for years, which finally turned out to be hepatic EHE. Liver transplantation has been recognized as the therapeutic method of choice due to the considerable extent of liver involvement and nonresponse to medications.
Coefficient Bounds for a New Families of m-Fold Symmetric Bi-Univalent Functions Defined by Bazilevic Convex Functions
Authors: Abd Bedaa Alawi , Wanas Abbas Kareem
Published: November 2023

In this paper, we find upper bounds for the first two Taylor-Maclaurin $\left|a_{m+1}\right|$ and $\left|a_{2m+1}\right|$ for two new families $L_{\Sigma_m}(\delta, \gamma ; \alpha)$ and $L_{\Sigma_m}^{*}(\delta, \gamma ; \alpha)$ of holomorphic and $m$-fold symmetric bi-univalent functions associated with the Bazilevic convex functions defined in the open unit disk $U$. Further, we point out several certain special cases for our results.
Uso de la aplicación Leoteca para reducir el analfabetismo funcional en niños de educación básica general
Authors: Cevallos Molina María José , Basantes Yugcha Evelyn Lisbeth
Published: November 2023

La comprensión lectora es la capacidad de entender y comprender un texto. Implica la capacidad de interpretar, analizar y reflexionar sobre la información contenida y de establecer conexiones e inferencias a partir de dicho contenido. La comprensión lectora implica no sólo leer palabras y su significado literal, sino también comprender el contexto, identificar las ideas principales, hacer inferencias, predicciones, establecer relaciones causa-efecto y juzgar la calidad y exactitud del texto. Es por ello que el principal objetivo de la investigación es proporcionar información sobre la aplicación Leoteca como parte de una estrategia global para reducir el analfabetismo funcional y mejorar las habilidades lectoras de los niños de educación general básica. La aplicación puede incluir funciones interactivas como preguntas de comprensión lectora, juegos y actividades relacionadas con los libros, estas actividades ayudan a los niños a comprender mejor el texto que leen y a desarrollar importantes habilidades de comprensión lectora, como el pensamiento lógico, la identificación de ideas principales y el análisis de personajes. El método del estudio es deductivo, ya que se recabó información con el fin de sacar conclusiones basadas en los diferentes estudios publicados o expuestos. Lo que facilitó la interpretación profunda del análisis de resultados sobre el tema tratado en este artículo, demostrado que la aplicación Leoteca es una herramienta tecnológica útil para reducir el analfabetismo funcional en los niños.
Análisis de la violencia en parejas de los estudiantes universitarios de la carrera de diseño gráfico
Authors: Calderón Peñafiel Jazmín Maricela , Hernández Naranjo Kevin Mauricio
Published: November 2023

La violencia en las relaciones de pareja es frecuente, en un principio estas situaciones estaban enmarcadas en el contexto de relaciones matrimoniales o de unión libre, pero esto ha cambiado, evidenciándose en relaciones entre adolescentes o universitarios. El objetivo de la investigación es analizar las dimensiones de violencia en los estudiantes de la carrera de diseño gráfico de la Universidad Técnica del Norte (Ecuador), de esta manera se busca identificar si existe una relación estadísticamente significativa entre género y el vínculo existente entre padres con el nivel de violencia recibida. El estudio está en el marco del paradigma cuantitativo analizando la información recopilada y cualitativo describiendo las diferentes dimensiones de violencia; el universo estudiado fueron los 208 estudiantes de diseño gráfico, aplicando una encuesta a una muestra representativa de 176 estudiantes (84,6%). Utilizando la prueba de hipótesis Chi Cuadrado se encontró que no hay correspondencia entre el género y la relación de padres con el nivel de violencia recibida (p>0.05). Concluyendo así que los alumnos se encuentran en un nivel entre bajo y moderado en las dimensiones de violencia y que a su vez este nivel no está condicionado al género ni a la relación que poseen los padres de la población estudiada.
Comparison Of Feat Examination Results Using Direct Slide And Sedimentation Methods For Detecting Soil Transmidet Helmint (STH) Worm Infection In Primary School Students
Authors: Kahfi Aulia  , Sitepu Rahmadani
Published: November 2023

The worms are parasitic infections that occur frequently and are estimated to infect 1-45 billion individuals worldwide. There are several types of worms that infect humans, namely roundworms (Ascaris lumbricoides), whipworms (Trichuris trichura), and hookworms or hookworms (Ancylostoma duodenale and necator americanus). The method used in this research is descriptive analytical method, which is the method used to view the description of the examination results from a sample. The population of this study was elementary school students with a sample of 50 students. Based on the results of the study using the direct slide method, negative results were obtained with a percentage of 100% with a total frequency of 50 students. If using the sedimentation method, 3 students were infected with Ascaris lumbrichoides with a percentage of 6.0% and 47 students were not infected with a percentage of 94.0% with a total sample of 50 students. Based on the results of the research using the direct slide and sedimentation methods, the results showed that the results of the two methods used were influenced by different sensitivity.
THE CENTURY-OLD TREND OF "DE-ECONOMIZATION" OF RUSSIAN HUMAN GEOGRAPHY: DETERMINANTS, CONSEQUENCES, WAYS OF OVERCOMING
Authors: Druzhinin A.G. , Kuznetsova O.V.
Published: November 2023

Modern geopolitical and geo-economic processes not only initiate large-scale metamorphoses of the territorial organization of Russian society, but also bring to the forefront issues of positive economic dynamics of both the country as a whole and its individual regions, municipalities, traditionally developed also in line with the logic of economic and geographical analysis. The purpose of the article is to comprehend the century-old trend of changing the role and positions of the actual "economic topics" in the social science "branch" of geographical science, identification of related problem situations and priorities. The presented analysis is based on the author's content analysis of scientific materials published in leading Russian geographical periodicals since the 1920s, as well as statistics of dissertations in the Russian Federation over the past two decades based on the funds of the State Scientific Library. Based on this information, a stable trend of prolonged multi-stage "de-economization" of domestic economic geography is revealed, its main causes and consequences are characterized. It is shown that the "displacement" of economic topics to the periphery of scientific research, which continued in post-Soviet Russian human geography, manifests itself in both quantitative (reduction in the number and proportion of relevant works) and qualitative (increasing lack of accounting for economic determinants and effects in spatial analysis) changes. The basic conditions and the most important directions of "re-economization" of human geography research in modern Russia are emphasized. At the same time, special emphasis is placed on the potential of increasing geographical and economic synthesis (in its subject-object, instrumental, organizational and personnel aspects), as well as on the associated opportunities to increase the practical, national economic, resource-oriented focuses of human geography.
PHYTOCENOTIC INCIDENCE OF RHODODÉNDRON AURÉUM GEORGI (ERICACEAE) OF THE UDOKAN RIDGE, TRANS-BAIKAL TERRITORY
Authors: Zhelibo T.V.
Published: November 2023

The paper presents data on phytocoenotic confinement of Rhododendron aureum Georgi, 1775 (Ericaceae) in the Udokan range. Using classical geobotanical methods, 79 populations of Rhododendron aureum were studied within the boundaries of the Trans-Baikal Territory. Within the fragment of R . aureum , the species is found within larch-siberian dwarf pine communities, larch yernic, pure siberian dwarf pine communities and areas of mountain tundra. Ecological densities and distribution differ even in similar communities. The most common associated species are Pinus pumila , Ledum palustre , Vaccinium vitis-idaea , Vaccinium uliginosum and others. The projective coverage of mosses and lichens can also vary from 5 to 95%. This work is particularly important for the assessment of biodiversity and future conservation efforts in areas that are rich in natural resources and minerals
PECULIARITIES OF DYNAMICS OF SEASONAL DEVELOPMENT OF WOODY PLANTS AT PETER THE GREAT BOTANIC GARDEN IN 2022
Authors: Firsov G.A. , Fadeeva I.V.
Published: November 2023

The article discusses the dynamics of the onset of phenological stages in 2022 and the features of the seasonal development of woody plants in the Botanical Garden of Peter the Great, depending on the weather conditions of winter and the subsequent growing season. The winter 2021/22 was normal on its duration (105 days) and comparatively mild. The coldest month was December (-7,5), with absolute minimum -23,1(26 December), not reaching the figures observed in the past (-34,7 ...10 January 1987). The frost damages of majority of trees and shrubs was absent or small, not more than half of annual growth. The peculiarity of season of 2022 was abnormally warm weather of the second half and the end of summer, with hot temperature in August: 20,6. This is the record for the whole period of instrumental meteorological observations since 1752. In such conditions the Autumn began as late as on the 10-th of September which is the record during 43-years monitoring since 1980. Apparently the warming of the climate of Saint-Petersburg is continuing and strengthening The autumnal season has the tendency to more late beginning and to enlarging of its duration. In such conditions the assortment of trees and shrubs promising on its winter hardiness for culture at the North-West of Russia is enlarging. There are more and more plants which were considered to be subtropical and indoor only, but nowadays successfully are winter hardy, produce flowers and fruits and may be successfully cultivated outdoor.
THE PROBLEMS AND PROSPECTS OF UTILIZATION OF SEWAGE SLUDGE AND RECLAMATION OF DISTURBED LANDS IN THE NORTH-WEST OF RUSSIA AND WAYS TO SOLVE THEM JOINTLY
Authors: Sorokin S.N. , Nedbaev I.S.
Published: November 2023

This review article raises the related issue of disturbed land reclamation and sewage sludge disposal. One of the components of disturbed land reclamation is considered - the problem of obtaining the most accessible and cheap fertile soil layer in sufficient quantity, options are listed: natural humus horizon; substrates based on peat of varying degrees of decomposition, based on wood waste from logging and woodworking, based on composts (leaf litter, agricultural waste, other). The main emphasis is placed on substrates based on municipal sewage sludge and pulp and paper mill waste, on the basis of which, during processing, organo-mineral compositions can be obtained with their further use as fertile soil layer. Gaps are noted in the modern regulatory framework, especially in relation to the use of sewage sludge as a fertile soil layer for the reclamation of disturbed land, including on forest fund lands. As an example, the situation with the use and disposal of sewage sludge in the Northwestern Federal District was considered based on data on the volume of waste production at existing wastewater treatment plants. Three categories of sewage sludge are distinguished by composition and two main methods of disposal currently used (incineration and removal to municipal service waste landfills). Separately, attention is focused on the situation with the accumulation of sewage sludge at wastewater treatment plants in settlements, including those with a pulp and paper mill as a city-forming enterprise. In conclusion, conclusions are drawn about the need to improve the existing regulatory framework in terms of the use of sewage sludge for the purposes of reclamation, about the priority of developing organo-mineral compositions that meet the tasks of reclamation, giving them an official status, and about the advisability of developing a strategic state document aimed at regulating the issues of reclamation of disturbed lands: the relevance of which is confirmed by the annual increasing areas, passing into the category of disturbed land.
ASSESSMENT OF THE DEPENDENCE OF WINTER WHEAT YIELD IN THE CENTRAL BLACK EARTH ECONOMIC REGION ON THE NATURE OF LARGE-SCALE CIRCULATION STRUCTURES OF THE ATMOSPHERE OF THE NORTHERN HEMISPHERE
Authors: Smirnov I.A. , Dronova E.A. , Brovkin A.G.
Published: November 2023

The relationship between the average values of winter wheat yields in five regions that are part of the Central Black Earth Economic Region and the nature of global atmospheric circulation was analyzed using the typification of elementary circulation mechanisms of the northern hemisphere of the Earth, compiled by B.L. Dzerdzeevsky. The assessment was made for the spring-summer vegetation period of the crop in question, based on data from 1961 to 2020. Also, based on the results obtained, a correlation and regression analysis of the dependence of winter wheat yield on the total repeatability of days with one or another type of global atmospheric circulation for the spring-summer and spring periods of vegetation was carried out. It is noted that the decrease in the yield of winter wheat in relation to the previous year in the regions under consideration is characteristic of the long-term predominance of one type of global atmospheric circulation in the Northern Hemisphere of the Earth. The increase is observed when, in total, during the spring-summer and spring parts of the vegetation period, there is a predominance of two different types of atmospheric circulation.
CONCEPTUAL PROVISIONS OF THE PARADIGM FORMATION AND REGULATION OF THE LABOR MARKET
Authors: STRASHKO Volodymyr
Published: November 2023

Introduction. In modern conditions, the economic development of Ukraine is connected with many factors, first of all, with the functioning of the labor market. It is characterized as a complex socio-economic phenomenon of society. Therefore, the study of the conceptual provisions of the paradigm of formation and regulation of the labor market is relevant and timely, given that their results will significantly affect the reproduction and development of labor resources of both enterprises, regions, and the state in general.
The purpose of the article is a thorough analysis and systematization of scientific approaches to the creation of a modern paradigm of formation and regulation of the labor market.
Research methods. During the writing of the scientific article, the historical method, methods of logical generalization, theoretical analysis and synthesis were applied.
The results. Attention is focused on definitions of the concept of "labor market", taking into account that in modern economic literature there is no single interpretation of this concept, sometimes it is defined as "labor market". Different views of the authors on these concepts are due to the purpose of researching specific aspects of labor activity. The analysis of literary sources makes it possible to assert that for the first time the definition of the essence of the labor market was developed in the works of modern researchers who used the scientific results of A. Smith, D. Ricardo, D. S. Mill, K. Marx, A. Marshall, A. Pigou, L. Walrasom, V. Pareto, J. Keynes, P. Samuelson and others.The analysis of the evolution of scientific views on the essence of the concept of "labor market" makes it possible to determine the main stages of its formation and regulation in the context of ensuring the effectiveness and efficiency of labor activity in modern conditions.
Conclusions. As a result of the generalization of scientific sources, domestic and foreign studies regarding the essence of the "labor market", it was established that there is no unified opinion regarding the definition of the meaning of this concept. This is explained by the complexity and multifaceted nature of the concept, which is in a state of transformation, associated with rapid changes. Defining the conceptual provisions of the paradigm of formation and regulation of the labor market will contribute to the development of economic theory and provide the essence of its conceptual apparatus.
Key words: labor market, division of labor, labor price, labor cost, supply and demand, wages.