bluuebunny/crossref_metadata_2025 huggingface dataset:
sujeito pronominal e a gramática comunicativa
Authors: Delamar José Volpato Dutra  , Jovino Pizzi
Published: June 2023

PIZZI, Jovino; DUTRA, Delamar José Volpato.  O sujeito pronominal e a gramática comunicativa: elementos para uma gramática da justiça. In: COLÓQUIO HABERMAS, 11.; COLÓQUIO DE FILOSOFIA DA INFORMAÇÃO, 2., 2015. Rio de Janeiro. Anais [...] Rio de Janeiro: Salute, 2016. Disponível em: https://coloquiohabermas.files. wordpress.com/2016/03/anais-xi-coloquio-habermas-e-ii-coloquio-de-filosofia-da-informacao1.pdf. Acesso em: 25 abr. 2023.
Synthesis and Chemistry of 1,2,4,3-Triazaphosphole Derivatives
Authors: Ali Tarik E. , Hassanin Noha M. , Assiri Mohammed A. , Abdel-Kariem Somaia M.
Published: June 2023

This review describes the progress made during the last fifty years in the synthesis
and chemistry of 1,2,4,3 triazaphospholes. This class of compounds has attracted tremendous homogeneous catalysis and interest in molecular materials science. These fascinating phosphorus
heterocycles have conjugated π systems with high degrees of aromaticity. 1,2,4,3-
Triazaphospholes can be designed through [3+2] cyclocondensation between functionalized
hydrazines with phosphonoimidates that allow the incorporation of additional donor substituents
into specific positions of the phosphorus heterocycle. In addition, [4+1] cyclocondensation
between functionalized amidrazones and active phosphorus reagents is the most synthetically
accessible method. The used strategies facilitated synthetic access to a completely
new set of triazaphospholes leading to a much broader scope for potential applications.
1,2,4,3-triazaphospholes displayed reactivity towards a variety of reagents. The phosphorus is particularly prone to
undergo oxidative 1,1-addition. Protic reagents such as alcohols, phenols, and amines can be added across the P=N
bond of 2H-1,2,4,3-triazaphospholes to yield the dihydro-1,2,4,3-triazaphosphole derivatives. 1H- and 2H-1,2,4,3-
triazaphospholes reacted with alcohols, ammonia and amines in the presence of sulfur or selenium to form dihydro-
1,2,4,3-triazaphosphole 3-chalcogenides. The appropriate difunctional reagents such as glycols, 2-azido alcohols
and phenol with a heterodiene function in the ortho position reacted with 2H-1,2,4,3-triazaphospholes to yield
products formed via 1,2-addition on P=N bond. Similar behavior is shown by 2-hydroxyacetophenone and 2-
hydroxy-benzophenone. 2H-1,2,4,3-Triazaphospholes reacted with acetylenes to form [3+2] cycloadducts; the latter
change to 1,2,3-diazaphospholes. [4+1] Cycloadditions occurred with α-diimines, azodicarboxylic esters, and
1,2-diketones; in the latter two cases, the resulting products dimerize.
Phytochemical and Pharmacological Potential ofFerula asafetida“Hing”
Authors: Singh Sonia , Shukla Arpit , Semwal Bhupesh C.
Published: June 2023

Asafoetida, also known as Hing, is a resinous gum derived from the roots of Ferula species, specifically Ferula asafetida. From ancient times, it has been employed both in the kitchen as a seasoning and in the practice of traditional medicine. In terms of pharmacognosy, asafoetida is comprised of a number of active chemicals, the most notable of which are coumarins, volatile oils (17%), and ferulic acid (60%). Ferulic acid and coumarins (40%) are two of the components that contribute to the medicinal value of this plant. The volatile oils are responsible for the strong odour and flavour of this plant. It is used for a variety of applications in the medical field. It is not only used as spices and condiments for the goal of imparting taste in curries, but it is also utilised in the treatment of gastrointestinal tract diseases, asthma, whooping cough, hypertension, and a variety of other conditions. The herb has been used to extract a variety of phytochemical components, including sesquiterpene coumarins, coumarins, diterpene coumarins, and chemicals containing sulphur. This manuscript provides a synopsis of the facts concerning the pharmacological activities and bioactive components of Ferula asafetida.
A Rationalized Approach to Design and Discover Novel Non-steroidal Derivatives through Computational Aid for the Treatment of Prostate Cancer
Authors: Kumar Shubham , Arora Pinky , Wadhwa Pankaj , Kaur Paranjeet
Published: June 2023

Background:

Prostate cancer is one of the most prevalent cancers in men, leading to the second most common cause of death in men. Despite the availability of multiple treatments, the prevalence of prostate cancer remains high. Steroidal antagonists are associated with poor bioavailability and side effects, while non-steroidal antagonists show serious side effects, such as gynecomastia. Therefore, there is a need for a potential candidate for the treatment of prostate cancer with better bioavailability, good therapeutic effects, and minimal side effects.

Objective:

This current research work focused on identifying a novel non-steroidal androgen receptor antagonist through computational tools, such as docking and in silico ADMET analysis.

Methods:

Molecules were designed based on a literature survey, followed by molecular docking of all designed compounds and ADMET analysis of the hit compounds.

Results:

A library of 600 non-steroidal derivatives (cis and trans) was designed, and molecular docking was performed in the active site of the androgen receptor (PDBID: 1Z95) using Auto- Dock Vina 1.5.6. Docking studies resulted in 15 potent hits, which were then subjected to ADME analysis using SwissADME. ADME analysis predicted three compounds (SK-79, SK-109, and SK-169) with the best ADME profile and better bioavailability. Toxicity studies using Protox-II were performed on the three best compounds (SK-79, SK-109, and SK-169), which predicted ideal toxicity for these lead compounds.

Conclusion:

This research work will provide ample opportunities to explore medicinal and computational research areas. It will facilitate the development of novel androgen receptor antagonists in future experimental studies.
Nanoemulsion based in-situ Gel for Ocular Delivery of Brimonidine Tartrate
Authors: Prajapati Bhupendra , Modi Chetna , Patel Uma , Kendre Prakash
Published: June 2023

Background:

Brimonidine tartrate is currently used to treat glaucoma; however, conventional
ocular formulations have some disadvantages in terms of treating disorders like glaucoma, as
less than 5% of the drug reaches a posterior segment of the eye; hence, there is a need for sustained
treatment.

Objective:

The objective of this study was to develop a self-nanoemulsion (SNEDDS) in-situ gel of
brimonidine tartrate to investigate the sustained-release effect to improve ocular bioavailability.

Method:

Oil, surfactant, and co-surfactant were screened using the pseudo-ternary phase diagram
(TPD) by aqueous-titration method based on the drug solubility. Nanoemulsions were evaluated for
the pH, viscosity, % drug content, % transmittance, dispersibility, particle size, zeta-potential, TEM,
and conductivity test. Nanoemulsion was incorporated into in-situ gel and evaluated for gelling capacity,
pourability, gel strength, in vitro drug release study, and drug release kinetics.

Result:

Castor oil (10%) as oil phase, Acrysol K-140 (10%) as surfactant, and PEG 400 (20%) as cosurfactant
were selected in preparation of SNEDDS from TPD. Evaluation parameters of SNEDDS
were found in an acceptable range. % Drug release showed the controlled release up to 8 hrs. Optimum
% drug content and % CDR were 100.25% and 92.46% after 12hrs, respectively. Optimized
SNEDDS in-situ gel followed the Higuchi model via diffusion mechanism having 0.99 R² value and
exhibiting sustained release up to 12 hr. Stability study proved no significant changes during storage.
In vitro, the ocular irritancy test proved suitable for ocular delivery.

Conclusion:

A sustained-release formulation was obtained by developing brimonidine tartrate
SNEDDS in-situ gel as a stable formulation without irritancy during ocular administration.
Flow Diversion for the Management of Posterior Circulation’s
Intracranial Aneurysms
Authors: Adamou Antonis , Alektoroff Kirill , Politi Maria , Alexandrou Maria , Roth Christian , Papanagiotou Panagiotis
Published: June 2023

:

The endovascular treatment of posterior circulation aneurysms, although challenging, has
been well-established due to various factors that limit the surgical approach in most cases. Flow diversion
has also been utilized in the treatment of such aneurysms, although its effectiveness and safety
still require evaluation. Numerous studies have examined the outcomes and complication rates in patients
treated with FD, resulting in varying findings. This review aimed to summarize the most recent
literature concerning the effectiveness of flow diversion devices in posterior circulation aneurysms.
Additionally, it highlights reports that compare results in the posterior versus anterior circulation, as
well as flow diversion versus stent-assisted coiling.
A Comprehensive Mini Review on the Natural Product Bacopa monnieri
for the Management of Alzheimer’s Disease
Authors: Jain Naman , Tambekar Omkar , Goel Tanvi , Bodhankar Subhash Laxmanrao , Bansode Deepali Amol
Published: June 2023

Central nervous system disorders are expected to profoundly impact the global healthcare needs
of the human community in this era. Senile decay of neurons is (Alzheimers Disease) AD. The hallmark of
the pathophysiology of AD disease has two pivotal features: extracellular beta-amyloid deposition and intracellular
tau hyperphosphorylation. New medicine-based psychoactive treatments have met with modest effectiveness
due to the multifactorial nature of these diseases. As a result, there is an increasing need for new
products that can address various receptors and enhance behavioral abilities independently or in tandem with
traditional medications. Herbal products focused on conventional expertise have recently been widely popular
in developed and developing countries. Ayurveda is a medical science that deals with the treatment of
diseases using naturally occurring plant products. Ayurveda claims to have a large number of neuroprotective
herbs. This review discusses the pharmacological effects and therapeutic properties of In vivo, In vitro,
In silico and human clinical trials of (Bacopa monnieri) BM against AD.
Nuclear Reactors
Authors: Kohale Ritesh , Dhoble Sanjay J. , Chopra Vibha
Published: June 2023

The present chapter is thoroughly dedicated to nuclear power reactors to
understand its fundamental conceptions. It also envelops the ancient background and
constructed nuclear fission reactors, important components of nuclear reactors, thermal
reactors, heavy water, moderator reactors, graphite-gas moderator reactors, and
accelerator-driven subcritical reactors (ADSR). The Oklo ancient nuclear reactor is the
foundation of natural fission reactors.
Origin and Applications of Radioactivity
Authors: Kohale Ritesh , Dhoble Sanjay J. , Chopra Vibha
Published: June 2023

A brief introduction to radioisotopes, radiation sources, types of radiation,
their applications, effects and occupational protection has been presented in this
chapter. The sources of radiation (whether natural or artificial) have been discussed.
However, special emphasis has been given to natural radioactive decay series and
artificial radioisotopes. Applications of ionizing radiations have significantly improved
the quality of human life. The contribution and application of radioisotopes in various
spheres of life, viz. tracing, radiography, food preservation and sterilization, eradication
of insects and pests, medical diagnosis and therapy and new varieties of crops in the
agricultural field, have been presented briefly. In this chapter, we have first discussed
the natural origin of radioactivity and the production of radioactive elements in neutron
and charged-particle streams, then exchanged the data and facts to see how high-energy
particles lose energy during their interaction with matter. Finally, fossil radioactivity,
artificial radioactivity, applications of radioactivity in medicinal and pharmaceutical
extent, and nuclear dating followed by some wide-range applications of radioactivity
have been discussed.
Antidiabetic Activity Methods
Authors: Kahraman Cigdem , Tatli Cankaya Iffet Irem
Published: June 2023

Diabetes mellitus (DM) is a metabolic disease characterized by the destruction of pancreatic β cells or reduced insulin secretion and action, and is one of the most common health problems worldwide. Its incidence is increasing at a high rate, resulting in enormous social costs. Various drugs show their effectiveness by improving insulin sensitivity, and reducing glucose production in the liver or other tissues. Several preclinical studies on diabetes-induced in animals using surgical, pharmacological or genetic methods demonstrated the effectiveness of these drugs. The anti-diabetic activity of plants has been attributed to the occurrence of primary and secondary metabolites characterized by many beneficial effects with advantages over chemical treatments. A number of studies have demonstrated the potential health benefits of phytocomponents in treating DM by acting on multiple molecular targets. Therefore, it is important to test in vitro assays. This review includes methods for the evaluation of preclinical anti-diabetic activities and summarizes the potential of natural resources to prevent and/or treat diabetes. In addition, the database contains information including the plant name, useful plant parts, active compounds, and their mechanisms of action, in which in vitro and in vivo methods were studied.
Bioremediation by Microalgae: Current Progress and Future Perspectives
Authors: Makaranga Abdalah , Shaikh Kashif M. , Nesamma Asha A. , Jutur Pannaga P.
Published: June 2023

Environmental pollution management through conventional methods in the
wake of new, recalcitrant, and increasing pollutant loads are no longer adequate or
sustainable. Bioaugmentation for pollutant removal is an environmental (water and
soil) decontamination approach alternative to the popular and traditional physico.chemical methods. Despite bioaugmentation’s attractiveness based on being greener
than the traditional methods, there are still several bottlenecks towards operating some
bioaugmented processes optimally. Most bioaugmentation problems arise during
upscaling successful lab-scale trials to industrial operations. In most cases, the
bioaugmented micro-organisms survive for just a short span of time before their
populations decrease prior to completion of the pollutant removal task. Research on
various aspects meant to address this and other bioaugmentation challenges has been
partly successful and such efforts are still ongoing. As part of evaluating and
optimising bioaugmentation processes, sustainability concepts should always be
considered at every stage of these activities. The application of bioaugmentation
techniques is also gaining popularity in other industries, such as biogas production.
Physiochemical Analysis of River Sutlej, Sindh and the Arabian Sea to Evaluate the Water Quality
Authors:   Department of Chemistry, Gov ernment  Sadiq College Women University Bahawalpur , Pakistan, Anjum Saima , Syeda Afroz Hussain , Jabeen Mussarat , Zafar Ansa  Madeeha , Shaheen Aqeela , Arshad Muhammad
Published: June 2023

Globally, water pollution is caused primarily by growing populations, urbanization, and modern agricultural techniques. In this study, freshwater samples were collected from Satluj river, Sindh river, and Arabian sea to assess water quality. A variety of physicochemical parameters were measured in these samples, including pH (7.5 to 8.4), color (variable), odor, turbidity (7 NTU to 18 NTU), taste (salty/bitter), total dissolved solids (182 mg/L to 34768 mg/L), total soluble solids (52 mg/L to 1244 mg/L), EC (109 µS/cm to 51488 µS/cm), total hardness/Ca+2+Mg+2 (25 mg/L to 125 mg/L), total alkalinity or CO3 -2 , HCO3 - (80 mg/L to 172 mg/L), exchangeable ions like Cl- (27 mg/L to 19742 mg/L), F- (0.3 mg/L to 1.29 mg/L), SO4 -2 (30 mg/L to 2974 mg/L), PO4 -3 (8 mg/L to 35 mg/L), NO2 -2 (18 mg/L to 43 mg/L), Mn+2 (0.0002 mg/L to 0.63 mg/L), Cu (0.0005 mg/L to 0.08 mg/L), Cd+2 (0.0005 mg/L to 0.88 mg/L), Cr+3 (0.003 mg/L to 0.32 mg/L), Zn+2 (0.001 mg/L to 2.72 mg/L), Fe+2 (0.01 mg/L to 0.9 mg/L), Ni+2 (0.002 mg/L to 0.23 mg/L), Na+ (15 mg/L to 10157 mg/L), K+ (4.4 mg/L to 379 mg/L), Ca+2 (20 mg/L to 380 mg/L), Mg+2 (5.4 mg/L to 1584 mg/L) tested by standard methods reported in Association of Official Analytical Chemists (AOAC) with little modifications. Most of the parameters studied in these water samples were beyond the National Environment Quality Standard of drinking water guidelines for seawater, but within acceptable limits for rivers. Consequently, these trends made seawater unfit for the survival of aquatic plants and marine life as well as for the people who use river water for domestic and agricultural purposes.
The impact of personality traits on interpersonal dynamics at zero acquaintance
Authors: Halberstadt Alexandra L. , Pincus Aaron L.
Published: June 2023

The current study aimed to examine the relationship between personality traits and interpersonal states. Eighty undergraduate participants were administered personality trait inventories, then 40 dyads were video recorded doing collaborative tasks. These video recordings were coded for moment-to-moment communion and agency using Continuous Assessment of Interpersonal Dynamics. Actor-Partner Interdependence Modeling was used to understand the impact of personality traits on interpersonal dynamics (average, variability, slope, complementarity on agency and communion). The results showed that there were no relationships between personality traits and dynamics. There were two main limitations that may explain these results. First, behavior may have been influenced more by social norms to be friendly and take turns than personality traits, especially in this “strong situation”. Second, it may be useful to aggregate behavior over multiple situations to capture variance attributable to traits. Future studies should aggregate behavior over multiple situations and/or change the situational constraints on behavior in order to determine the relationship between states and traits.
Study on Tobacco Control-Related Stakeholders’ Perspective on Tobacco Control Policies and Practice Towards Teenagers and Children Under Sharia Law Setting in Aceh
Authors: Hasnur Hanifah , Septiani Riza , Arifin Vera Nazhira , Presilawati Febyolla , Aletta Alma , Helfianti Sutri , Muhammad Muhammad , Lastri Surna , Perdana Luthfi Nanda , Zahara Meutia , Santi Tahara Dilla
Published: June 2023

Banda Aceh City Qanun Number 5 of 2016 concerning Smoking Free Areas and MPU Fatwa Number 18 of 2014 concerning Smoking in the Islamic view are two regional policies that have been issued and must be implemented optimally to limit and reduce smoking consumption, especially among adolescents and children in Aceh. This study aims to assess the perspectives of tobacco control-related stakeholders on tobacco control policies and practices in Aceh Province for children and adolescents. This study uses a qualitative study design by conducting Focus Group Discussions with twelve people as representatives of stakeholders related to tobacco control efforts in Aceh. The smoking culture of the Acehnese people which has integrated into their way of life has made teenagers and children vulnerable to exposure to cigarettes. But on the other hand, the Islamic view of smoking is in line with the principles of tobacco control where smoking can harm children and adolescents, so it is strictly prohibited in the Islamic view. Therefore, it is suggested that tobacco control interventions in Aceh for children and adolescents can focus on interventions that use a socio-cultural approach. This can guarantee the success of the tobacco control intervention program carried out in certain areas such as Aceh Province, which still has very clear socio-cultural values. In addition, a shared understanding of the dangers of smoking and making clear the law against smoking will strengthen tobacco control in Aceh, where so far the people have carried out everything based on sharia. Strict sanctions for youth and children who smoke and adequate resources are other keys to the success of the practice and implementation of tobacco control policies in Aceh Province.
Increasing the Entrepreneurial Independence of Correctional Families through the Development of Degung Arts
Authors: Ali Abdullah , Nurhayati Sri , Musa Safuri , Ansori Ansori
Published: June 2023

This study aims to uncover and interpret data about the development of correctional inmates through game art in increasing the entrepreneurial independence of inmates at Class IIA Karawang prison. This research uses a qualitative approach with a case study method. Data collection techniques used include observation, interviews, and literature studies. The research informants consisted of 5 inmates, 1 head of LAPAS, and the supervisor of the LAPAS gamelan art. The results of this study indicate that developing the Degung art of the assisted members in achieving entrepreneurial independence at Class IIA Karawang LAPAS, namely the compatibility between the coaching program and the potential and needs of the assisted residents, while indicators of increasing entrepreneurial independence after participating in Degung art coaching can be seen when the development of Degung art is in progress. In progress, inmates can be more patient in playing gamelan gamelan, agile and follow the supervisor's directions, so that when the term of imprisonment is over, inmates can control themselves more differently than when they first entered prison, the socialization skills of inmates are increasing, and the motivation of entrepreneurship inmates is growing. penitentiary.
Essays in Linguistic Ethnography
Authors: Blackledge Adrian , Creese Angela
Published: June 2023

This book argues for an approach to linguistic ethnography which departs from the perspective of the academic researcher, to amplify instead the voices of participants, researchers and collaborators. It reflects on ways of reporting research which add multiple perspectives and represent ambiguity more meaningfully than traditional academic prose.
ANALYSIS OF FLASH FLOOD POTENTIAL INDEX (FFPI) AND SCENARIOS ASSESSMENT IN SHAH ALAM USING GIS APPROACH
Authors: Mohd Yassin Nurul A. , Adnan Nor Aizam , Md Sadek Eran S. S.
Published: June 2023

Nowadays, there is an increase in the frequency of flash floods, which can have disastrous effects on both the economy and people's lives. In this study, the flash floods in Shah Alam are analysed using the Flash Flood Potential Index (FFPI) assessment method, which utilises four significant parameters, namely ground slope, land use, soil type, and NDVI, as outlined in the FFPI model that was first developed in 2003. The study reveals that the study area has a medium risk of flash floods, with an index value of five (5) to six (6). Flash flood risk is considered in all study scenarios, with a probability of over 50%. Scenario 2 produces the best results, with a 71% chance of Shah Alam being hit by a highlevel flash flood and a 22% chance of being hit by a medium-level flash flood. Since the FFPI is a dimensionless index ranging from 1 to 10, and the percentage of FFPI in Shah Alam is 47.48% for the value of 5 (median index), it is concluded that Shah Alam is in the medium risk group for daily flash floods. The FFPI is a suitable index to be used in Malaysia for predicting urban flood risk. Additionally, it is recommended to incorporate the calculation of factors or parameters that contribute to flash floods using weighting and ranking, particularly related to the drainage system and precipitation.
AUSPICIOUS GREEN RETROFIT STRATEGIES IN TWO-STORY TERRACE HOUSES: CASE STUDY OF PETALING JAYA SELANGOR MALAYSIA
Authors: Ramli Siti Aishah , Yunus Julitta , Mohd Nordin Rumaizah , Hassan Padzil@Fadzil , Mohd Tajul Hasnan Mohd Tajul Izrin
Published: June 2023

The surge of terrace house retrofitting practices has evoked sustainability concerns among the construction players. With the popularised means of upgrading the house condition, green retrofit becomes critical to achieving sustainable retrofitting among the existing residential building. Hence, this study aims to evaluate the potential application of green retrofit strategies in a two-story terrace house. The investigations were made concerning the Petaling Jaya District housing development. This thorough investigation involved analysing the retrofitting behaviour of over 2,946 cases leading to the key building components for applying the green retrofit approach. The outcome of the analysis shows that despite the common practice of retrofitting, the result mostly does not depict the implementation of a green approach in which the majority of upgraded works only reached the second degree – only 30% of improvements involved. The high rate of upgrading actions initiated depicts an immense potential for green retrofit strategies to be administered among the existing residential building stock, taking the measures towards more enforceable roles in pushing the country's low carbon movements forward.
COST BENEFIT ANALYSIS (CBA) IN BUILDING INFORMATION MODELLING (BIM) APPLICATION IN GOVERNMENT HEALTHCARE FACILITIES PROJECTS IN MALAYSIA
Authors: Omar Fazleemardyana , Mohd Fateh Mohd Ashraf
Published: June 2023

The healthcare industry in Malaysia is expected to grow to 127 billion ringgit by 2027. This vast investment definitely involved massive construction activities, which subsequently, require an advanced support system, to ensure the deliverable. Integration of CBA and BIM will further enhance the government construction project delivery. The level of BIM adoption in Malaysia's Construction industry is still low due to several obstacles; lack of knowledge of BIM, lack of data on the return on investment of BIM, and implementation cost and benefits. The objective of this paper was to identify the current approach of CBA toward BIM application in Government Healthcare Facilities in Malaysia. A mixed method with a nonprobability sampling technique was adopted. Where, 53 out of 90 respondents of the BIM expert population registered with the Public Works Department (PWD) BIM Centre have replied to the questionnaire. Meanwhile, five (5) semi-structured interview sessions were conducted. The findings have discovered that, awareness of the BIM application in the construction industry is important in this digital era. Nevertheless, the integration of CBA in BIM in Malaysia can be considered still low, compared to other countries such as Singapore and Australia. The integration of CBA in BIM adoption falls under level 3 of BIM Maturity.
THE FORMULATION OF SUSTAINABLE AND HIGHEST BEST-USE (SHBU) MODEL FOR FELDA LANDUSE DEVELOPMENT
Authors: Mokhtar Salbiah , Abdul Rashid Mohd Fadzil , Kamaruddin Siti Mazwin , Abdul Kamar Muhammad Asri , Abdullah Suzanah , Ali Mohamad Azal Fikry
Published: June 2023

FELDA land development focuses on settlements and agricultural areas, hence it is crucial for them to be managed efficiently. This study aims to establish a model that integrates sustainable land development with high income returns from the land. Therefore, this study identifies the elements essential for sustainable and highest best-use (SHBU). Several research approaches have been conducted namely Focus Group Discussion, documents analysis and questionnaire survey in order to search for key elements to be adapted into the SHBU model. From the analysis, five elements of the Sustainability and Highest-Best Use (SHBU) model, are discovered that they comprise of FELDA industries-based crops (FIbC) and SHBU, Strategic plan management (SPM), FELDA business centre (FBC), FELDA residential compound (FRC) and FELDA agro-preneur (FagP). These five-dimension SHBU model serves as a tool to assess the case study of FELDA settlement in order to come up with strategies to solve land development issues.
TRANSPORTATION BARRIERS CONFRONTED BY MOBILITY-CHALLENGED TRAVELLERS IN KLANG VALLEY
Authors: Kamarudin Hikmah , Abdul Kadir Syazwani , Alias Roslinda , Othman Rani Diana
Published: June 2023

Accessibility enables individuals' full participation in society, which results in social justice and equity, thus promoting social sustainability. However, research indicates that physical barriers in the built environment impede disabled people, resulting in marginalisation when their inclusion is tied to physical space. Commonly, accessibility of the built environment is evaluated using an access audit with a predetermined checklist. Little effort has been made to explore disabled people's life experiences accessing the city centre. This qualitative study involves twenty go-along interviews with mobility-challenged travellers to learn about their experiences using land transportation from around Klang Valley to Kuala Lumpur city centre. Mobility-challenged travellers, notably wheelchair users, still need help to reach their destination with the current transportation services. In general, transportation use in Klang Valley has several issues, including the lack of accessible facilities and lack of safety concerns from service providers. These issues have psycho-emotional impacts on disabled people.
Modeling of optical inhomogeneities in Cr-=SUP=-2+-=/SUP=-:CdSe lasers with a moving active element
Authors: Volkov M.V.  , Garutkin V.A  , Zakharov N.G.  , Mishcenko G.M.  , Ryabov V.O.  , Starikov F.A.
Published: June 2023

The work is devoted to modeling the heating of moving active elements from CdSe and estimates emerging optical inhomogeneities. Active elements in the form of a parallelepiped are considered, which rotated in a circle perpendicular to the generation axis. As a result of calculations, it was found that the temperature distribution in the active element that occurs during the operation of the laser can be represented as the sum of two components. The first component is formed due to the balance between heat emission in the active element due to pumping and heat removal from it, which leads to the appearance of an aberration, which is the sum of "tilt" and "defocusing". The second component is formed directly during the passage of the pump spot through the active element, is determined only by the heat release density and is not related to the cooling method of the active element. It leads to the appearance of "Gaussian" aberration, the amplitude of this aberration is directly proportional to the power of heat emission and inversely proportional to the frequency of rotation of the active element. Keywords: mobile active elements, optical inhomogeneities of the refractive index, Cr2+:CdSe laser.
Electrochemical performance of LIB anodes based on silicon monoxide: the effect of disproportionation and treatment in HF
Authors: Grushina A. A.  , Lozhkina D. A.  , Krasilin A. A.  , Rumyantsev A. M.  , Astrova E.V.
Published: June 2023

Composite SiO/C anodes for lithium-ion batteries (LIB) obtained by carbonization of silicon monoxide with fluorocarbon were investigated. Preliminary modification of the initial silicon monoxide was carried out by disproportionation and subsequent treatment in hydrofluoric acid. The study of the elemental composition of modified SiO and the electrochemical performance of composite anodes made from it showed that the oxygen content in the oxide matrix played a decisive role in changing their behavior. Depletion of it with oxygen as a result of treatment in HF had a beneficial effect, leading to higher stability of the electrodes during cycling, an increase in their capacity, coulombic efficiency and rate capability. Keywords: composite SiO/C anodes, lithium-ion batteries, treatment in HF.
Deuda externa y crecimiento económico. Una calibración para México
Authors: Casares Gil Enrique R. , García-Salazar María Guadalupe , Plata-Pérez Leobardo , Ramos-Varela José Manuel
Published: June 2023

Objetivo: Se aplica el modelo de Blanchard (1983) para México. Se analiza la acumulación de la deuda externa y su sostenibilidad. Metodología: Se calibra el modelo para el año 2019. Utilizando el método de eliminación del tiempo, se determinan los brazos estables del modelo. Resultados: Se realizan tres simulaciones que promueven la producción. Primero, un aumento en la productividad produce que la Proporción Deuda Externa/PIB (PDEPIB) aumente al 26.9%. Segundo, una disminución de la tasa de crecimiento de la población produce que la PDEPIB se incremente ligeramente. Tercera, una disminución de la Tasa de Interés Internacional (TII) produce un gran aumento en PDEPIB, al 44.01%, nivel sostenible. Se muestra que PDEPIB es muy sensible a la TII, que puede producir sobreendeudamiento. Recomendaciones: La sensibilidad de PDPIB a la TII, nos pone en aviso de tener políticas macroeconómicas prudentes. Limitaciones: los hogares carecen de restricciones al crédito internacional. Originalidad: Esta metodologia no ha sido aplicada a México. Conclusiones: Los ciclos económicos por los cuales transita la producción y la deuda externa de México, van aparejados con la variación de la TII, sobreendeudamiento siempre estará presente.
Improving Telehealth Equity in Response to COVID-19 in California: ACTIVATE and Lighthouse
Authors: Lindeman David
Published: June 2023

Background

In response to the significant stressors on health care delivery created by COVID-19, CITRIS Health and partner organizations developed 2 telehealth solutions through a rapid co-design process: Lighthouse and ACTIVATE. These programs were developed to support providers serving underserved and vulnerable populations who lack the tools and resources to support patients with chronic illness or who are isolated. These challenges were exacerbated by the COVID-19 pandemic, which increased the need for resources to support vulnerable patients who could not come into a clinic in person or were isolated and lacked access to services. ACTIVATE and Lighthouse apply 2 different telehealth strategies to reach vulnerable populations.

Objective

This paper presents lessons learned from the design, development, and implementation of 2 innovative telehealth programs developed to improve health care delivery, access to care, digital literacy, and patient outcomes: ACTIVATE and Lighthouse.

Methods

ACTIVATE is a comprehensive digital health pathway for community health centers that care for those who are medically underserved. ACTIVATE is an innovative, evidence-based, and sustainable telehealth program, designed to benefit vulnerable populations in rural and agricultural communities in the California Central Valley who experience significant health disparities. Lighthouse focuses on connecting older adults in congregate affordable housing, which are settings where residents are particularly vulnerable to isolation, the lack of health care resources, and limited to no access to the internet. Lighthouse provides digital literacy training as well as access to broadband internet with the goal of increasing communication, engagement, and access to health care.

Results

This presentation will discuss successful design and implementation strategies as well as organizational and policy barriers to program operations.

Conclusions

In addition to reviewing program and implementation outcomes, strategies for replication and sustainability will be discussed. Although developed in response to COVID-19, the ultimate success of Lighthouse and ACTIVATE is dependent upon its successful scaling beyond the pandemic.

Conflicts of Interest

None declared.
The Minimum Data Set for Rare Diseases: Systematic Review
Authors: Bernardi Filipe Andrade , Mello de Oliveira Bibiana , Bettiol Yamada Diego , Artifon Milena , Schmidt Amanda Maria , Machado Scheibe Victória , Alves Domingos , Félix Têmis Maria
Published: June 2023

Background

The minimum data set (MDS) is a collection of data elements to be grouped using a standard approach to allow the use of data for clinical and research purposes. Health data are typically voluminous, complex, and sometimes too ambiguous to generate indicators that can provide knowledge and information on health. This complexity extends further to the rare disease (RD) domain. MDSs are essential for health surveillance as they help provide services and generate recommended population indicators. There is a bottleneck in international literature that reveals a global problem with data collection, recording, and structuring in RD.

Objective

This study aimed to identify and analyze the MDSs used for RD in health care networks worldwide and compare them with World Health Organization (WHO) guidelines.

Methods

The population, concept, and context methodology proposed by the Joanna Briggs Institute was used to define the research question of this systematic review. A total of 4 databases were reviewed, and all the processes were reported using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology. The data elements were analyzed, extracted, and organized into 10 categories according to WHO digital health guidelines. The quality assessment used the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) checklist.

Results

We included 20 studies in our review, 70% (n=14) of which focused on a specific health domain and 30% (n=6) of which referred to RD in general. WHO recommends that health systems and networks use standard terminology to exchange data, information, knowledge, and intelligence in health. However, there was a lack of terminological standardization of the concepts in MDSs. Moreover, the selected studies did not follow the same standard structure for classifying the data from their MDSs. All studies presented MDSs with limitations or restrictions because they covered only a specific RD, or their scope of application was restricted to a specific context or geographic region. Data science methods and clinical experience were used to design, structure, and recommend a fundamental global MDS for RD patient records in health care networks.

Conclusions

Our study highlights the difficulties in standardizing and categorizing findings from MDSs for RD because of the varying structures used in different studies. The fundamental RD MDS designed in this study comprehensively covers the data needs in the clinical and management sectors. These results can help public policy makers support other aspects of their policies. We highlight the potential of our results to help strategic decisions related to RD.

Trial Registration

PROSPERO CRD42021221593; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=221593

International Registered Report Identifier (IRRID)

RR2-10.1016/j.procs.2021.12.034
Web-Based Learning for General Practitioners and Practice Nurses Regarding Behavior Change: Qualitative Descriptive Study
Authors: Raumer-Monteith Lauren , Kennedy Madonna , Ball Lauren
Published: June 2023

Background

Supporting patients to live well by optimizing behavior is a core tenet of primary health care. General practitioners and practice nurses experience barriers in providing behavior change interventions to patients for lifestyle behaviors, including low self-efficacy in their ability to enact change. Web-based learning technologies are readily available for general practitioners and practice nurses; however, opportunities to upskill in behavior change are still limited. Understanding what influences general practitioners’ and practice nurses’ adoption of web-based learning is crucial to enhancing the quality and impact of behavior change interventions in primary health care.

Objective

This study aimed to explore general practitioners’ and practice nurses’ perceptions regarding web-based learning to support patients with behavior change.

Methods

A qualitative, cross-sectional design was used involving web-based, semistructured interviews with general practitioners and practice nurses in Queensland, Australia. The interviews were recorded and transcribed using the built-in Microsoft Teams transcription software. Inductive coding was used to generate codes from the interview data for thematic analysis.

Results

In total, there were 11 participants in this study, including general practitioners (n=4) and practice nurses (n=7). Three themes emerged from the data analysis: (1) reflecting on the provider of the Healthy Lifestyles suite; (2) valuing the web-based learning content and presentation; and (3) experiencing barriers and facilitators to using the Healthy Lifestyles suite.

Conclusions

Provider reputation, awareness of availability, resources, content quality, usability, cost, and time influence adoption of web-based learning. Perceived quality is associated with culturally tailored information, resources, a balance of information and interactivity, plain language, user-friendly navigation, appealing visual presentation, communication examples, and simple models. Free web-based learning that features progress saving and module lengths of less than 2 hours alleviate perceived time and cost barriers. Learning providers may benefit by including these features in their future behavior change web-based learning for general practitioners and practice nurses.
Contribution of Frailty to Multimorbidity Patterns and Trajectories: Longitudinal Dynamic Cohort Study of Aging People (Preprint)
Authors: Carrasco-Ribelles Lucía A , Cabrera-Bean Margarita , Danés-Castells Marc , Zabaleta-del-Olmo Edurne , Roso-Llorach Albert , Violán Concepción
Published: June 2023

BACKGROUND

Multimorbidity and frailty are characteristics of aging that need individualized evaluation, and there is a 2-way causal relationship between them. Thus, considering frailty in analyses of multimorbidity is important for tailoring social and health care to the specific needs of older people.

OBJECTIVE

This study aimed to assess how the inclusion of frailty contributes to identifying and characterizing multimorbidity patterns in people aged 65 years or older.

METHODS

Longitudinal data were drawn from electronic health records through the SIDIAP (Sistema d’Informació pel Desenvolupament de la Investigació a l’Atenció Primària) primary care database for the population aged 65 years or older from 2010 to 2019 in Catalonia, Spain. Frailty and multimorbidity were measured annually using validated tools (eFRAGICAP, a cumulative deficit model; and Swedish National Study of Aging and Care in Kungsholmen [SNAC-K], respectively). Two sets of 11 multimorbidity patterns were obtained using fuzzy c-means. Both considered the chronic conditions of the participants. In addition, one set included age, and the other included frailty. Cox models were used to test their associations with death, nursing home admission, and home care need. Trajectories were defined as the evolution of the patterns over the follow-up period.

RESULTS

The study included 1,456,052 unique participants (mean follow-up of 7.0 years). Most patterns were similar in both sets in terms of the most prevalent conditions. However, the patterns that considered frailty were better for identifying the population whose main conditions imposed limitations on daily life, with a higher prevalence of frail individuals in patterns like chronic ulcers & peripheral vascular. This set also included a dementia-specific pattern and showed a better fit with the risk of nursing home admission and home care need. On the other hand, the risk of death had a better fit with the set of patterns that did not include frailty. The change in patterns when considering frailty also led to a change in trajectories. On average, participants were in 1.8 patterns during their follow-up, while 45.1% (656,778/1,456,052) remained in the same pattern.

CONCLUSIONS

Our results suggest that frailty should be considered in addition to chronic diseases when studying multimorbidity patterns in older adults. Multimorbidity patterns and trajectories can help to identify patients with specific needs. The patterns that considered frailty were better for identifying the risk of certain age-related outcomes, such as nursing home admission or home care need, while those considering age were better for identifying the risk of death. Clinical and social intervention guidelines and resource planning can be tailored based on the prevalence of these patterns and trajectories.
Landscape of Biomedical and Health Research in the Eastern Mediterranean: A 15-Year Analysis (Preprint)
Authors: Tadmouri Ghazi , Mandil Ahmed , Soukarieh Itab , Salma Israa , Assaad Nada , Khatib Marwa , Rashidian Arash
Published: June 2023

BACKGROUND

Research mapping relies on bibliometric analyses to estimate and analyze research productivity of an institution, country or region, in general, or investigate a specific domain of research. Bibliometric methods offer the advantage of using data from bibliographic databases with minimal bias or involvement from the researchers themselves. Numerous bibliometric analyses have taken place in the Eastern Mediterranean Region (EMR) to assess the publication situation either at a national scale or with a disease-specific focus. Yet, there are not enough data to establish a national/regional health research agenda.

OBJECTIVE

To assess biomedical and health research outputs over two decades in all EMR countries for the years 2004-2018.
To measure their year-to-year alignment with the regional strategic health priority areas identified by the WHO Regional Office for the Eastern Mediterranean (WHO-EMRO); namely, Health System Strengthening (HSS), Maternal and Child Health (MCH), Non-Communicable Diseases (NCD), Communicable Diseases (CD), and Emergency Preparedness and Response (EPR).

METHODS

The number of biomedical and health articles originating from EMR each country of the EMR for the study period, as obtained from the PubMed search, was used as an indicator of a country’s total biomedical research production level. Data were weighted to take into account global research output, represented by the total number of articles indexed in PubMed per year, and the population size of each country.

RESULTS

By inspecting the overall raw data for biomedical research productivity in the EMR, a clear increasing trend is observed. Notably, five most-performing countries contributed to nearly 82% of all published biomedical research during 2004-2018, namely Iran (43%), followed by Egypt (14%), Saudi Arabia (11%), Pakistan (8%), and Tunisia (6%). According to the World Bank Group's economic classification, most of the performing countries in the EMR belong to the lower- and upper-middle income categories. All other remaining EMR countries had contributions of less than 4% of the overall biomedical research publications during the study period.

CONCLUSIONS

While data collected in this study offer a modest view of the social organization in the EMR through patterns of co-authorship and research collaborations, it is important to develop robust methodologies to be able to investigate this important aspect in more detail in the future.