bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease
Authors: Liu Xingzhu , Chen Yanfei , Yang Yanfei , Su Zhongjian , Wang Feng , Zhanghuang Chenghao , Wu Yuqin , Zhang Xing
Published: July 2023

Objective

To investigate the correlation between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease.

Methods

Two hundred and thirty four children with Kawasaki disease (KD group), 200 healthy children (normal group) and 208 children with non-KD fever (fever group) were enrolled. General clinical indicators, the concentration of serum MMPs, TIMP-1, FG-α,fibrinogen level, molecular function (FMPV/ODmax) and FGA Thr312Ala polymorphism were detected individually by testing peripheral venous blood after fasting in the morning.

Results

There was no significant difference in average age among the three groups, which were 3.03 ± 1.22 years, 3.17 ± 1.30 years, and 3.21 ± 1.31 years, respectively. Compared with those in the fever group, the levels of white blood cell count (WBC), platelet count (PLT), procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and fibrinogen (Fg) levels were significantly increased in the KD group. Red blood cell count (RBC) and hemoglobin (Hb) levels were significantly decreased (p < 0.05).The concentration of serum MMPs, TIMP-1, and FG-α in the KD and fever groups were significantly higher than those in the normal group (p < 0.05). The concentration of MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1, and FG-α in the KD group were significantly higher than those in the fever group (p < 0.05).The KD group was divided into two subgroups,55 patients with combined CAL and 179 patients without combined CAL. The plasma fibrinogen concentration in the combined CAL group was significantly higher than that in the non-combined CAL and normal groups (p < 0.01). There was no statistically significant difference in FMPV/ODmax among the three groups (p > 0.05). Compared with normal group, the FGA GG, GA, and AA genotype and G, A allele frequency of the FGA gene polymorphism in the KD group showed no significant difference (p > 0.05). In the KD group, the most common type in children with CAL was GA, while the most common type in children without CAL was GG.

Conclusion

MMPs and FG-α were significantly upregulated in KD patients. The proportion of FGA genotype GA in children with CAL was significantly higher than that in children without CAL, suggesting that FGA gene polymorphisms affect coronary artery lesion in children with KD.
The efficacy and safety of haloperidol for the treatment of delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Authors: Huang Jian , Zheng Hui , Zhu Xianfeng , Zhang Kai , Ping Xiaofeng
Published: July 2023

Purpose

Delirium is common during critical illness and is associated with poor outcomes. Therefore, we conducted this meta-analysis to investigate the efficacy and safety of haloperidol for the treatment of delirium in critically ill patients.

Methods

Randomized controlled trials enrolling critically ill adult patients to compare haloperidol with placebo were searched from inception through to February 20th, 2023. The primary outcome were delirium-free days and overall mortality, secondary outcomes were length of intensive care unit stay, length of hospital stay, and adverse events.

Results

Nine trials were included in our meta-analysis, with a total of 3,916 critically ill patients. Overall, the pooled analyses showed no significant difference between critically ill patients treated with haloperidol and placebo for the delirium-free days (MD −0.01, 95%CI −0.36 to 0.34, p = 0.95, I2 = 30%), overall mortality (OR 0.89, 95%CI 0.76 to 1.04, p = 0.14, I2 = 0%), length of intensive care unit stay (MD −0.06, 95%CI −0.16 to 0.03, p = 0.19, I2 = 0%), length of hospital stay (MD −0.06, 95%CI −0.61 to 0.49, p = 0.83, I2 = 0%), and adverse events (OR 0.90, 95%CI 0.60 to 1.37, p = 0.63, I2 = 0%).

Conclusion

Among critically ill patients, the use of haloperidol as compared to placebo has no significant effect on delirium-free days, overall mortality, length of intensive care unit and/or hospital stay. Moreover, the use of haloperidol did not increase the risk of adverse events.
Influence of native and exotic plant diet on the gut microbiome of the Gray's Malayan stick insect, Lonchodes brevipes
Authors: Lim Yan Zhen , Poh Yan Hong , Lee Kevin C. , Pointing Stephen Brian , Wainwright Benjamin J. , Tan Eunice Jingmei
Published: July 2023

Herbivorous insects require an active lignocellulolytic microbiome to process their diet. Stick insects (phasmids) are common in the tropics and display a cosmopolitan host plant feeding preference. The microbiomes of social insects are vertically transmitted to offspring, while for solitary species, such as phasmids, it has been assumed that microbiomes are acquired from their diet. This study reports the characterization of the gut microbiome for the Gray's Malayan stick insect, Lonchodes brevipes, reared on native and introduced species of host plants and compared to the microbiome of the host plant and surrounding soil to gain insight into possible sources of recruitment. Clear differences in the gut microbiome occurred between insects fed on native and exotic plant diets, and the native diet displayed a more species-rich fungal microbiome. While the findings suggest that phasmids may be capable of adapting their gut microbiome to changing diets, it is uncertain whether this may lead to any change in dietary efficiency or organismal fitness. Further insight in this regard may assist conservation and management decision-making.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H2S)-producing variants of Escherichia coli
Authors: Mazumder Razib , Hussain Arif , Rahman Mohammad Mustafizur , Phelan Jody E. , Campino Susana , Abdullah Ahmed , Clark Taane G. , Mondal Dinesh
Published: July 2023

Atypical Escherichia coli forms exhibit unusual characteristics compared to typical strains. The H2S-producing variants of some atypical E. coli strains cause a wide range of illnesses in humans and animals. However, there are sparse reports on such strains worldwide. We performed whole-genome sequencing (WGS) and detailed characterization of four H2S-producing E. coli variants from poultry and human clinical sources in Dhaka, Bangladesh. All four isolates were confirmed as E. coli using biochemical tests and genomic analysis, and were multidrug-resistant (MDR). WGS analysis including an additional Chinese strain, revealed diverse STs among the five H2S-producing E. coli genomes, with clonal complex ST10 being detected in 2 out of 5 genomes. The predominant phylogroup detected was group A (n = 4/5). The blaTEM1B (n = 5/5) was the most predominant extended-spectrum beta-lactamase (ESBL) gene, followed by different alleles of blaCTX-M (blaCTX-M -55,-65,-123; n = 3/5). Multiple plasmid replicons were detected, with IncX being the most common. One E. coli strain was classified as enteropathogenic E. coli. The genomes of all five isolates harbored five primary and four secondary function genes related to H2S production. These findings suggest the potential of these isolates to cause disease and spread antibiotic resistance. Therefore, such atypical E. coli forms should be included in differential diagnosis to understand the pathogenicity, antimicrobial resistance and evolution of H2S-producing E. coli.
Recently evolved combination of unique sulfatase and amidase genes enables bacterial degradation of the wastewater micropollutant acesulfame worldwide
Authors: Bonatelli Maria L. , Rohwerder Thore , Popp Denny , Liu Yu , Akay Caglar , Schultz Carolyn , Liao Kuan-Po , Ding Chang , Reemtsma Thorsten , Adrian Lorenz , Kleinsteuber Sabine
Published: July 2023

Xenobiotics often challenge the principle of microbial infallibility. One example is acesulfame introduced in the 1980s as zero-calorie sweetener, which was recalcitrant in wastewater treatment plants until the early 2010s. Then, efficient removal has been reported with increasing frequency. By studying acesulfame metabolism in alphaproteobacterial degraders of the genera Bosea and Chelatococcus, we experimentally confirmed the previously postulated route of two subsequent hydrolysis steps via acetoacetamide-N-sulfonate (ANSA) to acetoacetate and sulfamate. Genome comparison of wildtype Bosea sp. 100-5 and an acesulfame degradation-defective mutant revealed the involvement of two plasmid-borne gene clusters. The acesulfame-hydrolyzing sulfatase is strictly manganese-dependent and belongs to the metallo beta-lactamase family. In all degraders analyzed, it is encoded on a highly conserved gene cluster embedded in a composite transposon. The ANSA amidase, on the other hand, is an amidase signature domain enzyme encoded in another gene cluster showing variable length among degrading strains. Transposition of the sulfatase gene cluster between chromosome and plasmid explains how the two catabolic gene clusters recently combined for the degradation of acesulfame. Searching available genomes and metagenomes for the two hydrolases and associated genes indicates that the acesulfame plasmid evolved and spread worldwide in short time. While the sulfatase is unprecedented and unique for acesulfame degraders, the amidase occurs in different genetic environments and likely evolved for the degradation of other substrates. Evolution of the acesulfame degradation pathway might have been supported by the presence of structurally related natural and anthropogenic compounds, such as aminoacyl sulfamate ribonucleotide or sulfonamide antibiotics.
Deep learning-based framework for real-time upper limb motion intention classification using combined bio-signals
Authors: Syed A. Usama , Sattar Neelum Y. , Ganiyu Ismaila , Sanjay Chintakindi , Alkhatib Soliman , Salah Bashir
Published: July 2023

This research study proposes a unique framework that takes input from a surface electromyogram (sEMG) and functional near-infrared spectroscopy (fNIRS) bio-signals. These signals are trained using convolutional neural networks (CNN). The framework entails a real-time neuro-machine interface to decode the human intention of upper limb motions. The bio-signals from the two modalities are recorded for eight movements simultaneously for prosthetic arm functions focusing on trans-humeral amputees. The fNIRS signals are acquired from the human motor cortex, while sEMG is recorded from the human bicep muscles. The selected classification and command generation features are the peak, minimum, and mean ΔHbO and ΔHbR values within a 2-s moving window. In the case of sEMG, wavelength, peak, and mean were extracted with a 150-ms moving window. It was found that this scheme generates eight motions with an enhanced average accuracy of 94.5%. The obtained results validate the adopted research methodology and potential for future real-time neural-machine interfaces to control prosthetic arms.
Altered interhemispheric functional connectivity in patients with comitant exotropia before and after surgery: a resting-state fMRI study
Authors: Chen Xiang-Xun , Chen Wen , Hu Hao , Zhao Meng , Liu Hu , Xu Xiao-Quan , Wu Fei-Yun , Wang Jie
Published: July 2023

Purpose

To assess the interhemispheric homotopic connectivity alterations in patients with comitant exotropia (CE) before and after surgery, using resting-state functional magnetic resonance imaging (rs-fMRI) with voxel-mirrored homotopic connectivity (VMHC).

Methods

Thirty-four patients with CE and twenty-four well-matched healthy controls (HCs) were enrolled to undergo a preoperative rs-fMRI scan. The rs-fMRI scan was performed again in twenty-four patients 1 month after surgery. The VMHC method was applied to evaluate the group differences of interhemispheric functional connectivity. The correlations between VMHC values and clinical variables were analyzed in the patient group.

Results

Compared with HCs, 34 patients with CE showed significantly increased VMHC values in occipital lobe (cuneus/superior occipital gyrus/middle occipital gyrus/calcarine), cerebellar area 8/cerebellar Crus1 area, and cerebellar Crus1 area. In CE group, VMHC in the cuneus was positively correlated with stereoacuity (r = 0.417, P = 0.014), meanwhile VMHC in the cerebellar Crus1 area was positively correlated with stereoacuity (r = 0.395, P = 0.021). One month after surgery, the 24 CE patients with follow-up showed decreased VMHC values in the cuneus and superior occipital gyrus compared with preoperative collection, meanwhile, non-significant difference compared with HCs.

Conclusion

Our study revealed the interhemispheric homotopic connectivity changes of patients with CE in the occipital lobe and cerebellum before and after surgery. The findings may provide a new perspective for the neurological alterations of CE.
Utilization of clinical and radiological parameters to predict cognitive prognosis in patients with mild-to-moderate traumatic brain injury
Authors: Wang Xi , Hui Xiaobo , Wang Xiangyu , Huang Baosheng , Gan Xiaokui , Liu Xingdong , Shen Zhiyan , Sun Yi , Li Lixin
Published: July 2023

Background

Cognitive impairment is a common sequela following traumatic brain injury (TBI). This study aimed to identify risk factors for cognitive impairment after 3 and 12 months of TBI and to create nomograms to predict them.

Methods

A total of 305 mild-to-moderate TBI patients admitted to the First Affiliated Hospital with Nanjing Medical University from January 2018 to January 2022 were retrospectively recruited. Risk factors for cognitive impairment after 3 and 12 months of TBI were identified by univariable and multivariable logistic regression analyses. Based on these factors, we created two nomograms to predict cognitive impairment after 3 and 12 months of TBI, the discrimination and calibration of which were validated by plotting the receiver operating characteristic (ROC) curve and calibration curve, respectively.

Results

Cognitive impairment was detected in 125/305 and 52/305 mild-to-moderate TBI patients after 3 and 12 months of injury, respectively. Age, the Glasgow Coma Scale (GCS) score, >12 years of education, hyperlipidemia, temporal lobe contusion, traumatic subarachnoid hemorrhage (tSAH), very early rehabilitation (VER), and intensive care unit (ICU) admission were independent risk factors for cognitive impairment after 3 months of mild-to-moderate TBI. Meanwhile, age, GCS score, diabetes mellitus, tSAH, and surgical treatment were independent risk factors for cognitive impairment after 12 months of mild-to-moderate TBI. Two nomograms were created based on the risk factors identified using logistic regression analyses. The areas under the curve (AUCs) of the two nomograms to predict cognitive impairment after 3 and 12 months of mild-to-moderate TBI were 0.852 (95% CI [0.810, 0.895]) and 0.817 (95% CI [0.762, 0.873]), respectively.

Conclusion

Two nomograms are created to predict cognitive impairment after 3 and 12 months of TBI. Age, GCS score, >12 years of education, hyperlipidemia, temporal lobe contusion, tSAH, VER, and ICU admission are independent risk factors for cognitive impairment after 3 months of TBI; meanwhile, age, the GCS scores, diabetes mellitus, tSAH, and surgical treatment are independent risk factors of cognitive impairment after 12 months of TBI. Two nomograms, based on both groups of factors, respectively, show strong discriminative abilities.
A rare case of pituitary metastasis from hepatocellular carcinoma: case report and literature review
Authors: Cheng Yuanchen , Feng Ming
Published: July 2023

Presence of pituitary metastases (PMs) is a relatively rare clinical situation, especially when originating from hepatocellular carcinoma (HCC). A 73-year-old man presented with headaches, diplopia, and soon impaired vision, as well as gastrointestinal symptoms. Computed tomography (CT) and magnetic resonance imaging (MRI) of the brain revealed a space-occupying mass in the sellar region. The patient had a history of hepatocellular carcinoma and recent abdominal ultrasound and positron emission tomography (PET) indicated recurrence and metastases. Endoscopic transnasal transsphenoidal tumor excision was performed, and postoperative pathological report confirmed the diagnosis of HCC PM. In the literature review, 17 published cases of HCC PMs were summarized. Both the diagnosis and management of HCC PMs are difficult. Patients who had HCC-related history and new-onset headaches or diplopia should be inspected with a suspicion of metastatic lesions. Surgical intervention with transnasal endoscope is only recommended to ameliorate the symptoms and improve the life quality.
PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients
Authors: Di Donfrancesco Alessia , Berlingieri Christian , Giacomello Marta , Frascarelli Chiara , Magalhaes Rebelo Ana Paula , Bindoff Laurence A. , Reeval Segel , Renbaum Paul , Santorelli Filippo M. , Massaro Giulia , Viscomi Carlo , Zeviani Massimo , Ghezzi Daniele , Bottani Emanuela , Brunetti Dario
Published: July 2023

Introduction: Biallelic variants in PITRM1 are associated with a slowly progressive syndrome characterized by intellectual disability, spinocerebellar ataxia, cognitive decline and psychosis. The pitrilysin metallopeptidase 1 (PITRM1) is a mitochondrial matrix enzyme, which digests diverse oligopeptides, including the mitochondrial targeting sequences (MTS) that are cleaved from proteins imported across the inner mitochondrial membrane by the mitochondrial processing peptidase (MPP). Mitochondrial peptidases also play a role in the maturation of Frataxin, the protein affected in Friedreich’s ataxia. Recent studies in yeast indicated that the mitochondrial matrix protease Ste23, which is a homologue of the human insulin-degrading enzyme (IDE), cooperates with Cym1 (homologue of PITRM1) to ensure the proper functioning of the preprotein processing machinery. In humans, IDE could be upregulated by Peroxisome Proliferator-Activated Receptor Gamma (PPARG) agonists.

Methods: We investigated preprotein processing, mitochondrial membrane potential and MTS degradation in control and patients’, and we evaluated the pharmacological effect of the PPARG agonist Pioglitazone on mitochondrial proteostasis.

Results: We discovered that PITRM1 dysfunction results in the accumulation of MTS, leading to the disruption and dissipation of the mitochondrial membrane potential. This triggers a feedback inhibition of MPP activity, consequently impairing the processing and maturation of Frataxin. Furthermore, we found that the pharmacological stimulation of PPARG by Pioglitazone upregulates IDE and also PITRM1 protein levels restoring the presequence processing machinery and improving Frataxin maturation and mitochondrial function.

Discussion: Our findings provide mechanistic insights and suggest a potential pharmacological strategy for this rare neurodegenerative mitochondrial disease.
Using phase interference to characterize dynamic properties—a review of constant gradient, portable magnetic resonance methods
Authors: Selby William , Balcom Bruce J. , Newling Benedict , Mastikhin Igor
Published: July 2023

Spatially resolved motion-sensitized magnetic resonance (MR) is a powerful tool for studying the dynamic properties of materials. Traditional methods involve using large, expensive equipment to create images of sample displacement by measuring the spatially resolved MR signal response to time-varying magnetic field gradients. In these systems, both the sample and the stress applicator are typically positioned inside a magnet bore. Portable MR instruments with constant gradients are more accessible, with fewer limitations on sample size, and they can be used in industrial settings to study samples under deformation or flow. We propose a view in which the well-controlled sensitive region of a magnet array acts as an integrator, with the velocity distribution leading to phase interference in the detected signal, which encodes information on the sample’s dynamic properties. For example, in laminar flows of Newtonian and non-Newtonian fluids, the velocity distribution can be determined analytically and used to extract the fluid’s dynamic properties from the MR signal magnitude and/or phase. This review covers general procedures, practical considerations, and examples of applications in dynamic mechanical analysis and fluid rheology (viscoelastic deformation, laminar pipe flows, and Couette flows). Given that these techniques are relatively uncommon in the broader magnetic resonance community, this review is intended for both advanced NMR users and a more general physics/engineering audience interested in rheological applications of NMR.
A switchable terahertz metamaterial absorber between ultra-broadband and dual bands
Authors: Ren Zhi , Wang Wanqing , Zhao Yinghui , Chang Siqi , Ren Guanhua , Li Songtao , Wang Ruoxing
Published: July 2023

Based on the phase change properties of vanadium dioxide (VO2), we propose a terahertz metamaterial absorber that can be switched flexibly between ultra-broadband and dual bands. The absorber consists of a resonator array above a conductive ground layer separated with a dielectric spacer, which includes four square-loop VO2 resonators and a crossed gold resonator in each unit cell. By changing the conductivity of VO2 through thermal control, the absorber can achieve the switching between ultra-broadband absorption and dual-band absorption. Simulation results show that at high temperature, the absorber realizes more than 90% absorption bandwidth in the range of 3.98 to 9.06 THz, which can be elucidated by the wave-interference theory and impedance matching theory. At low temperature, up to 95% of the dual-band absorption occurs at 5.95 and 6.95 THz, which originates the dipole mode and nonlocal surface-Bloch mode of metal resonators. In addition, the absorber has the advantages of polarization-independence and wide-angle absorption. Compared with previous studies, our design can switch between two absorption modes and its absorption performance is greatly improved. The proposed absorber design scheme is expected to expand terahertz devices and enable a variety of applications in the terahertz range, such as modulation, sensing, stealth, and switching devices.
The challenge of screen mediated shared reading for children’s learning and engagement
Authors: Read Kirsten , Harrison Hayley , Mireku Brianna , Ying Katrina
Published: July 2023

Introduction

Screen mediated shared reading (SMSR), which involves an adult reading a child a book through video-chat, is a recent development in shared reading. In this study, we investigated whether, as in in-person shared reading, children could learn new words from SMSR, and whether having a physical copy of the book to follow along with impacted children’s novel word retention and engagement in this setting.

Method

Three- to 5-year-old participants (n = 34) were read an 8-page rhyming, “Meet the Friendly Monsters” story by a researcher over Zoom, via screen sharing an e-version of the story used in previous studies. Participants were randomly assigned to one of two conditions: SMSR with or without a paper copy of the book to follow along with. The session was recorded to measure children’s engagement behaviors during the reading. Novel word learning from the story was measured with both a multiple choice identification test and a monster naming test, both administered immediately after the initial reading, then re-administered 10–14 days later. Engagement during the SMSR sessions was measured every 30-s on a scale of 1 (low engagement) to 5 (high engagement), and then averaged for each child.

Results

Results show that children overall performed slightly above chance on novel monster name retention from the SMSR. However, retention was not as strong as seen in other in-person shared reading studies using the same story. Additionally, while children remembered monster names with equal efficacy regardless of condition and level of engagement, there were still qualitative differences in the reading sessions depending on whether children had their own paper copy of the book to follow along with – in general, the ‘with book’ condition appeared to increase the challenges posed to children’s attention during SMSR, potentially making the word learning task more difficult.

Discussion

The findings of this study have implications for how to approach shared reading with young children in new contexts with the use of emerging technology. We raise future research questions for a better understanding of best practices for screen mediated shared reading.
The retrogenesis of age-related decline in declarative and procedural memory
Authors: Xie Chenwei , Fong Manson Cheuk-Man , Ma Matthew King-Hang , Wang Juliahna , Wang William Shiyuan
Published: July 2023

The retrogenesis hypothesis proposes that the order of breakdown of cognitive abilities in older adults is the reverse of the developmental order of children. Declarative and procedural memory systems, however, have been empirically understudied regarding this issue. The current study aimed to investigate whether retrogenesis occurs in the developmental and decline order of the declarative and procedural memory systems. Besides, we further investigated whether retrogenesis occurs in declarative memory, which was tested through the recognition of familiar and unfamiliar items. Both questions were investigated by looking at 28 Chinese younger adults and 27 cognitively healthy Chinese older adults. The recognition memory task and the Serial Reaction Time Task were administered on two consecutive days in order to measure their declarative and procedural memory, respectively. The results showed older adults performed significantly worse than younger adults for both tasks on both days, suggesting a decline in both declarative and procedural memory. Moreover, older adults exhibited relatively preserved declarative memory compared to procedural memory. This does not follow the expectations of the retrogenesis hypothesis. However, older adults demonstrated superior performance and a steeper rate of forgetting for recognizing familiar items than unfamiliar items. This reverses the developmental order of different patterns in the declarative memory system. Overall, we conclude that retrogenesis occurs in the declarative memory system, while does not in the decline order of the two memory systems; this understanding can better help inform our broader understanding of memory aging.
Global research trends and prospects on the first-generation college students from 2002 to 2022: a bibliometric analysis via CiteSpace
Authors: Fei Li , Kang Xizhen , Sun Weiming , Hu Boxiang
Published: July 2023

Objectives

To review literature related to first-generation college students, the paper aims to outline the research direction, identify prominent research topics and frontiers, report on current research trends, and offer valuable insights and fresh perspectives for future advancements in the field, utilizing CiteSpace.

Methods

CiteSpace is a citation visualization software designed to analyze the scholarly literature and uncover potential knowledge within it. This study retrieved articles related to first-generation college students from 2002 to 2022 from Web of Science Core Collection database. After collecting the data, CiteSpace V.6.1.R3 (64-bit) was used to perform analyses on various aspects, including annual publication output, top cited journals, country and institutional affiliations, prominent authors, cited references, and keywords. The data was visualized using tools such as knowledge maps, collaborative network analysis, cluster analysis, and strongest citation burst analysis.

Results

We obtained a total of 471 articles on first-generation college students. The number of publications annually is increasing, and the number of publications generally shows an upward trend, especially in 2017–2021 with a sharp growth. The United States has the most articles on this topic (395 articles), and it is also the most authoritative and influential country (with a centrality of 0.93). Followed by South Africa (14 articles) and Germany (14 articles), The top 10 cited journals and institutions are predominantly from the United States. When analyzing the top cited references and authors, the research consistently highlights the academic achievement and engagement of first-generation college students.

Conclusion

This study analyzed the current situation of first-generation college students field via CiteSpace, then identify the research hotspots and frontiers on first-generation college students. Current global trends in first-generation college students researches and the growing public awareness of academic performance and equality suggest that first-generation college students researches will grow in popularity with further breakthroughs.
Humanistic care relieves mental distress of inpatients in the shelter hospital during COVID-19 pandemic in Shanghai: a cross-sectional observational study
Authors: Xiao Dongdong , Huang Hua , Chen Min , Wang Jieying , Zhai Wei , Ye Jiaqi , Chen Minjie , Fang Weilin , Zhang Yeqian , Fu Zhiwei , Shen Yifei , Yan Ziji , Shen Chenlu , Qin Jun , Luo Yanli , Zheng Junhua
Published: July 2023

Objective

The prevalence of mental distress has been noted in shelter hospitals set up for COVID-19. Potential risk demographic and hospitalization factors were screened. We also aimed to determine whether humanistic care established in the shelter hospital was effective in ameliorating mental distress.

Methods

A cross-sectional observational survey-based single-centered study was conducted from 28th April to 5th May 2022 during the COVID-19 pandemic in Shanghai. Asymptomatic adult inpatients and those with mild symptoms were recruited for this study, and humanistic care measures were carried out by the administrative office according to the Work Program on Psychological Assistance and Social Work Services at the Shelter Hospital launched on 5th March 2020. Symptoms of mental distress, such as reported stress, anxiety, depression, and insomnia were measured using the Chinese Stress Response Questionnaire-28, the Chinese version of Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, and Insomnia Severity Index-7, respectively.

Results

In total, 1,246 out of 9,519 inpatients, including 565 (45.35%) women and 681 (54.65%) men, with a median age of 36 years responded to the survey. The overall prevalence of stress, anxiety, depression, and insomnia in inpatients was 94 (7.54%), 109 (8.75%), 141 (11.32%), and 144 (11.56%), respectively. Mental distress was aggravated by COVID-19-related symptoms, comorbidities, and prolonged hospital stays. A stable internet connection was the most effective measure to reduce stress and depression. Offering inpatient with study or work facilitations, and mental health education help to ameliorate anxiety and depression. Organizing volunteering was a potential protective factor against stress.

Conclusion

Humanistic care is crucial and effective for protecting against mental distress, which should be emphasized in shelter hospitals.
Behavioral and psychosocial factors related to mental distress among medical students
Authors: Carlos Kathleen M. , Ahmadi Hedyeh , Uban Kristina A. , Riis Jenna L.
Published: July 2023

Introduction

Physicians die by suicide at rates higher than the general population, with the increased risk beginning in medical school. To better understand why, this study examined the prevalence of mental distress (e.g., depressive symptoms and suicide risk) and behavioral and psychosocial risk factors for distress, as well as the associations between mental distress and risk factors among a sample of medical students in a pre–COVID-19-era.

Methods

Students enrolled in a large California medical school in 2018–2019 (N = 134; 52% female) completed questionnaires assessing sociodemographic characteristics, depression and suicide family history, health behaviors, and psychosocial wellbeing. Assessment scores indexing mental distress (e.g., depressive symptoms, thoughts of suicide in the past 12 months, suicide risk, and history of suicidality) and risk factors (e.g., stress, subjective sleep quality, alcohol use, impostor feelings, and bill payment difficulty) were compared across biological sex using chi-squared tests, and associations between mental distress and risk factors were determined through logistic regression.

Results

Elevated mental distress indicators were observed relative to the general public (e.g., 16% positive depression screen, 17% thought about suicide in previous 12 months, 10% positive suicide risk screen, and 34% history of suicidality), as well as elevated risk factors [e.g., 55% moderate or high stress, 95% at least moderate impostor feelings, 59% poor sleep quality, 50% screened positive for hazardous drinking (more likely in females), and 25% difficulty paying bills]. A positive depression screen was associated with higher stress, higher impostor feelings, poorer sleep quality, and difficulty paying bills. Suicidal ideation in the previous 12 months, suicide risk, and a history of suicidality were independently associated with higher levels of impostor feelings.

Discussion

Higher scores on assessments of depressive symptoms and suicidal thoughts and behaviors were related to several individual-level and potentially modifiable risk factors (e.g., stress, impostor feelings, sleep quality, and bill payment difficulties). Future research is needed to inform customized screening and resources for the wellbeing of the medical community. However, it is likely that the modification of individual-level risk factors is limited by the larger medical culture and systems, suggesting that successful interventions mitigate suicide risk for medical providers need to address multiple socio-ecological levels.
Frontiers of policy and governance research in a smart city and artificial intelligence: an advanced review based on natural language processing
Authors: Dong Liang , Liu Yunhong
Published: July 2023

This study presents an advanced review of policy and governance research in the context of smart cities and artificial intelligence (AI). With cities playing a crucial role in achieving the United Nations Sustainable Development Goals, it is vital to understand the opportunities and challenges that arise from the applications of smart technologies and AI in promoting urban sustainability. Using the Latent Dirichlet Allocation (LDA) method based on a three-layer Bayesian algorithm model, we conducted a systematic review of approximately 3700 papers from Scopus. Our analysis revealed prominent topics such as “service transformation,” “community participation,” and “sustainable development goals.” We also identified emerging concerns, including “open user data,” “ethics and risk management,” and “data privacy management.” These findings provide valuable insights into the current progress and frontiers of policy and governance research in the field, informing future research directions and decision-making processes.
Transperitoneal laparoscopic retrievement of a migrated prosthetic head after total hip arthroplasty: a case report
Authors: Ciciriello Simone , Gerosa Martino , Ghezzi Riccardo , Sogni Angelo , Incalza Ferdinando , Guttadauro Angelo , Maggioni Dario , Mari Giulio
Published: July 2023

The migration of a prosthetic head during total hip arthroplasty (THA) is a rare complication. Few cases are described in the literature, offering different solutions and surgical approaches for prosthetic head retrievement. Here, we present a case of successful laparoscopic transperitoneal retrieval of a prosthetic head migrated above the right iliac vein after THA with a posterolateral approach.
Case report: Neuropathic pain versus undesirable behavior in a Dachshund after hemilaminectomy surgery for an intervertebral disc extrusion
Authors: Santifort Koen M. , Plonek Marta , Mandigers Paul J. J.
Published: July 2023

A 5.5 years-old male Dachshund was presented for evaluation because of undesirable behavior including barking, biting, sucking and licking the right-side flank, ventrally and slightly caudally to the level of the surgical incision 7 days after hemilaminectomy for a right-sided L1-2 intervertebral disc extrusion. The dog was being treated with oral gabapentin 10 mg/kg q8h. Repeat clinical examination on three occasions after post-operative discharge did not reveal any signs of hyperesthesia or neurological deficits and the behavior was not observed in the clinic during consultations. During a separate day of hospital admittance with the aim of evaluating for the presence or absence of the behavior, the dog also did not exhibit the behavior. Oral paracetamol 12 mg/kg q8h was added to medical treatment. When the dog was discharged and returned home, the behavior was immediately seen again. When the owners implemented verbal punishment, the behavior immediately ceased. The owner verbally corrected the dogs’ behavior for two excitative days. Upon telephone consultation 3 days later, the owner reported that they only had observed three recurrences of the behavior that immediately ceased following verbal correction and did not recur thereafter. Oral analgesic medication was tapered and discontinued. No recurrence of the behavior was noticed during the next 2 months. The authors postulated the dog possibly expressed signs of neuropathic pain in the post-operative period, or that the behavior was of a “compulsive disorder-like” nature as it only occurred when the dog was at home and in the presence of the owner. The eventual outcome and result of verbal corrections implemented by the owner seem to support the latter. In conclusion, compulsive-like undesirable behavior should be considered a differential diagnosis in dogs in the post-operative period of procedures possibly associated with the development or expression of signs of neuropathic pain.
Analysis of the Impact of Public Services on Residents’ Health: A Spatial Econometric Analysis of Chinese Provinces
Authors: Jia Wei , Liu Lei , Wang Zhihao , Peng Gang
Published: July 2023

Objectives: The aim of this study was to explore the mechanism between public services and residents’ health, focusing on the role of spatial geographical factors.

Methods: Leveraging a comprehensive panel dataset encompassing 30 mainland Chinese provinces from 2007 to 2019, this study engineered a spatial Durbin model furnished with dual fixed effects through the application of the Lagrange multiplier, Hausman, and likelihood ratio tests. The primary objective was to delve into the repercussions of varying public service levels on residents’ health outcomes.

Results: The empirical findings reveal a palpable spatial autocorrelation between residents’ health outcomes and the public services levels dispensed across Chinese provinces. Intriguingly, an elevation in the public service level in a given province not only ameliorates its residents’ health outcomes but also triggers a spatial spillover effect, thereby positively influencing residents’ health in neighboring provinces. The rigorous endogeneity and robustness checks affirm the reliability of the principal outcomes.

Conclusion: Due to the increase in social uncertainty, all regions should break free of the administrative monopoly, enhance regional integration and development, and improve residents’ health status by clustering public service supply.
Modeling Investigation of Groove Effect on the Multipactor of Dielectric-Loaded Coaxial Low-Pass Filters
Authors: Shi Jincheng , Zhao Yuchao , Zhou Weixiang , Sun Baichang , Zhang Jinbo , Wang Dongliang , Liu Ying , Sun Teng , Zhang Xiangtian , Tie Weihao
Published: July 2023

Multipactor is a common discharge phenomenon occurring in space microwave systems. The surface microstructure has been verified to be effective in mitigating multipactor. In this work, we design a square coaxial low-pass filter (SCLPF) with dielectric sheets loaded to check the multipactor dependence on the structure parameters of the loaded dielectric sheets, and further model groove structures on the sensitive area surface to lower the risk of multipactor. Simulation results indicate that the SCLPF loaded with alumina and PTFE exhibits favorable operational characteristics, and the multipactor threshold is significantly improved after introducing the surface grooves. Then, we investigate the effects of three typical groove parameters, groove depth, groove number, and aspect ratio, on the multipactor threshold of the SCLPF device. The results show that the multipactor threshold rises at first as the groove number and groove depth increase, and then the threshold reaches a saturation status. For a deeper analysis of multipactor, we discuss how the grooves shelter the secondary electrons, and further mitigate the electron avalanche. Furthermore, the mechanisms of threshold saturation under the effect of groove parameters are analyzed in detail, and a contour map for the multipactor threshold of PTFE-loaded SCLPFs is given, which makes significant sense for predicting the multipactor threshold of the devices with its sensitive surface being grooved. The regularity of modulating the multipactor threshold by the groove structures obtained in this study is of engineering significance for suppressing multipactor in microwave devices in practical applications.
Fisher Information as General Metrics of Quantum Synchronization
Authors: Shen Yuan , Soh Hong Yi , Kwek Leong-Chuan , Fan Weijun
Published: July 2023

Quantum synchronization has emerged as a crucial phenomenon in quantum nonlinear dynamics with potential applications in quantum information processing. Multiple measures for quantifying quantum synchronization exist. However, there is currently no widely agreed metric that is universally adopted. In this paper, we propose using classical and quantum Fisher information (FI) as alternative metrics to detect and measure quantum synchronization. We establish the connection between FI and quantum synchronization, demonstrating that both classical and quantum FI can be deployed as more general indicators of quantum phase synchronization in some regimes where all other existing measures fail to provide reliable results. We show advantages in FI-based measures, especially in 2-to-1 synchronization. Furthermore, we analyze the impact of noise on the synchronization measures, revealing the robustness and susceptibility of each method in the presence of dissipation and decoherence. Our results open up new avenues for understanding and exploiting quantum synchronization.
A Pilot Study Using Entropy for Optimizing Self-Pacing during a Marathon
Authors: Palacin Florent , Poinsard Luc , Pycke Jean Renaud , Billat Véronique
Published: July 2023

A new group of marathon participants with minimal prior experience encounters the phenomenon known as “hitting the wall,” characterized by a notable decline in velocity accompanied by the heightened perception of fatigue (rate of perceived exertion, RPE). Previous research has suggested that successfully completing a marathon requires self-pacing according to RPE rather than attempting to maintain a constant speed or heart rate. However, it remains unclear how runners can self-pace their races based on the signals received from their physiological and mechanical running parameters. This study aims to investigate the relationship between the amount of information conveyed in a message or signal, RPE, and performance. It is hypothesized that a reduction in physiological or mechanical information (quantified by Shannon Entropy) affects performance. The entropy of heart rate, speed, and stride length was calculated for each kilometer of the race. The results showed that stride length had the highest entropy among the variables, and a reduction in its entropy to less than 50% of its maximum value (H = 3.3) was strongly associated with the distance (between 22 and 40) at which participants reported “hard exertion” (as indicated by an RPE of 15) and their performance (p < 0.001). These findings suggest that integrating stride length’s Entropy feedback into new cardioGPS watches could improve marathon runners’ performance.
Low-Temperature Fabrication of Flexible Dye-Sensitized Solar Cells: Influence of Electrolyte Solution on Performance under Solar and Indoor Illumination
Authors: Avilés-Betanzos Roberto , Oskam Gerko , Pourjafari Dena
Published: July 2023

Flexible photovoltaics is an attractive technology for product-integrated energy supply under both outdoor and interior conditions. In particular, dye-sensitized solar cells (DSSCs) based on flexible plastic conductive substrates provide ample opportunities for unique applications; however, they prevent the use of high-temperature processing steps usually applied in the fabrication of the solar cell. In the first part of this paper, we present an overview of a careful selection of the most relevant work in the field of flexible DSSCs (F-DSSCs), ranging from pioneering methodsto the most cutting-edge techniques. Key elements and critical considerations for the design of an efficient F-DSSC are also provided. In the second part, we report the fabrication of DSSCs on both rigid and flexible plastic substrates using low-temperature processing. Three different I−/I3− electrolyte configurations were tested. Rigid and F-DSSC showed 2.62% and 1.00% efficiency under 1 sun and an output power of 8.60 and 4.00 μW/cm−2 under low-light conditions, respectively. In this work, we report a novel solvent mixture that shows a significant enhancement of the performance of the low-temperature processed configuration, without adding steps in the fabrication process.
Improved Battery Balancing Control Strategy for Reconfigurable Converter Systems
Authors: Wan Guangwei , Zhang Qiang , Li Menghan , Li Siyuan , Fu Zehao , Liu Junjie , Li Gang
Published: July 2023

In order to address the issue of battery cell disparity in lithium-ion battery systems, battery balancing techniques are required. This paper proposes an improved battery balancing strategy within a reconfigurable converter system. The strategy is based on the state of charge (SOC) of batteries, and utilizes the reconfigurable converter system to transfer energy from battery modules with high SOC to those with lower SOC. Additionally, it allows for battery module balancing while supplying power to loads. A MATLAB/Simulink simulation model with five batteries was built to validate the effectiveness of the proposed balancing strategy under unloaded and loaded conditions. The simulation results demonstrate that the proposed strategy achieves more efficient and accurate battery module balancing compared to the previous balancing modes.
Experimental Assessment of Electromagnetic Fields Inside a Vehicle for Different Wireless Communication Scenarios: A New Alternative Source of Energy
Authors: Atanasov Nikolay Todorov , Atanasova Gabriela Lachezarova , Gârdan Daniel Adrian , Gârdan Iuliana Petronela
Published: July 2023

The search for new energy sources in the 21st century is a crucial topic with an essential economic and societal meaning. Today, energy from electromagnetic fields (EMFs) is considered a promising new energy source for ultra-low-power consumption devices, such as wearable devices and Internet of Things (IoT) sensors. The research goal of this study was to experimentally evaluate the electric field (E-field) inside a compact car for several realistic wireless communication scenarios and to explore the possibility of using these EMFs in energy-harvesting applications. For each scenario, we performed measurements of E-fields in an urban area, in two cases: when the car was in an open space without a direct line of sight to a base station, and when the car was in underground parking. The results show that the highest measured value of the electric field appeared during the voice calls via the GSM network. Moreover, the maximum measured values of the electric field during a UMTS, LTE and 5G voice call were five to six times lower than those in the GSM network.