bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic Levels of Pro-Inflammatory Cytokines and Post-Treatment Modulation in Tuberculous Lymphadenitis
Authors: Kathamuthu Gokul Raj , Moideen Kadar , Sridhar Rathinam , Baskaran Dhanaraj , Babu Subash
Published: March 2023

Pro-inflammatory cytokines are potent stimulators of inflammation and immunity and markers of infection severity and bacteriological burden in pulmonary tuberculosis (PTB). Interferons could have both host-protective and detrimental effects on tuberculosis disease. However, their role has not been studied in tuberculous lymphadenitis (TBL). Thus, we evaluated the systemic pro-inflammatory (interleukin (IL)-12, IL-23, interferon (IFN)α, and IFNβ) cytokine levels in TBL, latent tuberculosis (LTBI), and healthy control (HC) individuals. In addition, we also measured the baseline (BL) and post-treatment (PT) systemic levels in TBL individuals. We demonstrate that TBL individuals are characterized by increased pro-inflammatory (IL-12, IL-23, IFNα, IFNβ) cytokines when compared to LTBI and HC individuals. We also show that after anti-tuberculosis treatment (ATT) completion, the systemic levels of pro-inflammatory cytokines were significantly modulated in TBL individuals. A receiver operating characteristic (ROC) analysis revealed IL-23, IFNα, and IFNβ significantly discriminated TBL disease from LTBI and/or HC individuals. Hence, our study demonstrates the altered systemic levels of pro-inflammatory cytokines and their reversal after ATT, suggesting that they are markers of disease pathogenesis/severity and altered immune regulation in TBL disease.
Why Some People Are Hesitant to Receive COVID-19 Boosters: A Systematic Review
Authors: Limbu Yam B. , Huhmann Bruce A.
Published: March 2023

As the COVID-19 pandemic continues and transitions to an endemic stage, booster vaccines will play an important role in personal and public health. However, convincing people to take boosters continues to be a key obstacle. This study systematically analyzed research that examined the predictors of COVID-19 booster vaccine hesitancy. A search of PubMed, Medline, CINAHL, Web of Science, and Scopus uncovered 42 eligible studies. Globally, the average COVID-19 booster vaccination hesitancy rate was 30.72%. Thirteen key factors influencing booster hesitancy emerged from the literature: demographics (gender, age, education, income, occupation, employment status, ethnicity, and marital status), geographical influences (country, region, and residency), adverse events, perceived benefit/efficacy, perceived susceptibility, perceived severity, prior history of COVID-19 infection, vaccination status, vaccination recommendations, health status, knowledge and information, skepticism/distrust/conspiracy theories, and vaccine type. Vaccine communication campaigns and interventions for COVID boosters should focus on factors influencing booster confidence, complacency, and convenience.
Production and Immunological Characterization of scFv Specific to Epitope of Opisthorchis viverrini Rhophilin-Associated Tail Protein 1-like (OvROPN1L)
Authors: Geadkaew-Krenc Amornrat , Krenc Dawid , Thanongsaksrikul Jeeraphong , Grams Rudi , Phadungsil Wansika , Glab-ampai Kittirat , Chantree Pathanin , Martviset Pongsakorn
Published: March 2023

(1) Background: Opisthorchis viverrini is a significant health problem in the Mekong subregion of Southeast Asia, causing aggressive cholangiocarcinoma. Current diagnostic procedures do not cover early diagnosis and low infection. Hence, an effective diagnostic tool is still required. Immunodiagnosis seems promising, but attempts to generate monoclonal antibodies have not yet been successful. This study aims to develop a single-chain variable antibody fragment (scFv) against Rhophilin-associated tail protein 1-like (ROPN1L), the sperm-specific antigen of adult O. viverrini, which has not been reported elsewhere. (2) Methods: The target epitope for phage screening was L3-Q13 of OvROPN1L, which showed the highest antigenicity to human opisthorchiasis analyzed in a previous study. This peptide was commercially synthesized and used for phage library screening. The isolated phage was produced in a bacterial expression system and tested for specificity in vitro and in silico. (3) Results: One of fourteen phages, named scFv anti-OvROPN1L-CL19, significantly bound to rOvROPN1L compared with non-infected hamster fecal extracts. This phage clone was successfully produced and purified using Ni-NTA chromatography. Indirect ELISA demonstrated that scFv anti-OvROPN1L-CL19 has a high reactivity with O. viverrini-infected hamster fecal extracts (12 wpi, n = 6) in comparison with non-infected hamster fecal extracts (0 wpi, n = 6), while the polyclonal rOvROPN1L antibodies did not show such a difference. Molecular modeling and docking confirmed our in vitro findings. (4) Conclusion: scFv anti-OvROPN1L-CL19 could be used as an effective material for developing O. viverrini-immunodiagnostic procedures in the future.
Unimodular Approaches to the Cosmological Constant Problem
Authors: Jiroušek Pavel
Published: March 2023

We review selected aspects of unimodular gravity and we discuss its viability as a solution of the old cosmological constant problem. In unimodular gravity, the cosmological constant is promoted to a global degree of freedom. We highlight the importance of correctly setting up its initial data in order to achieve a resolution of the cosmological constant problem on a semi-classical level. We review recent path integral analysis of quantum aspects of unimodular gravity to note that the semi-classical findings carry over to the quantum level as well. We point out that a resolution of the problem inherently relies on a global constraint on the spacetime four-volume. This makes the theory closely related to the vacuum energy sequester, which operates in a similar way. We discuss possible avenues of extending unimodular gravity that preserve the resolution of the cosmological constant problem.
Viral Metagenomic Analysis of the Fecal Samples in Domestic Dogs (Canis lupus familiaris)
Authors: Wang Hongyan , Li Zongjie , Li Chuanfeng , Ma Yanfeng , Sun Qing , Zhang Hailong , Niu Guangbin , Wei Jianchao , Yao Huochun , Ma Zhiyong
Published: March 2023

Canine diarrhea is a common intestinal illness that is usually caused by viruses, bacteria, and parasites, and canine diarrhea may induce morbidity and mortality of domestic dogs if treated improperly. Recently, viral metagenomics was applied to investigate the signatures of the enteric virome in mammals. In this research, the characteristics of the gut virome in healthy dogs and dogs with diarrhea were analyzed and compared using viral metagenomics. The alpha diversity analysis indicated that the richness and diversity of the gut virome in the dogs with diarrhea were much higher than the healthy dogs, while the beta diversity analysis revealed that the gut virome of the two groups was quite different. At the family level, the predominant viruses in the canine gut virome were certified to be Microviridae, Parvoviridae, Siphoviridae, Inoviridae, Podoviridae, Myoviridae, and others. At the genus level, the predominant viruses in the canine gut virome were certified to be Protoparvovirus, Inovirus, Chlamydiamicrovirus, Lambdavirus, Dependoparvovirus, Lightbulbvirus, Kostyavirus, Punavirus, Lederbergvirus, Fibrovirus, Peduovirus, and others. However, the viral communities between the two groups differed significantly. The unique viral taxa identified in the healthy dogs group were Chlamydiamicrovirus and Lightbulbvirus, while the unique viral taxa identified in the dogs with diarrhea group were Inovirus, Protoparvovirus, Lambdavirus, Dependoparvovirus, Kostyavirus, Punavirus, and other viruses. Phylogenetic analysis based on the near-complete genome sequences showed that the CPV strains collected in this study together with other CPV Chinese isolates clustered into a separate branch, while the identified CAV-2 strain D5-8081 and AAV-5 strain AAV-D5 were both the first near-complete genome sequences in China. Moreover, the predicted bacterial hosts of phages were certified to be Campylobacter, Escherichia, Salmonella, Pseudomonas, Acinetobacter, Moraxella, Mediterraneibacter, and other commensal microbiota. In conclusion, the enteric virome of the healthy dogs group and the dogs with diarrhea group was investigated and compared using viral metagenomics, and the viral communities might influence canine health and disease by interacting with the commensal gut microbiome.
Porcine Reproductive and Respiratory Syndrome Virus Engineered by Serine Substitution on the 44th Amino Acid of GP5 Resulted in a Potential Vaccine Candidate with the Ability to Produce High Levels of Neutralizing Antibody
Authors: Choi Jong-Chul , Kim Min-Sik , Choi Hwi-Yeon , Kang Yeong-Lim , Choi In-Yeong , Jung Sung-Won , Jeong Ji-Yun , Kim Min-Chul , Cho Andrew Y. , Lee Ji-Ho , Lee Dong-Hun , Lee Sang-Won , Park Seung-Yong , Song Chang-Seon , Choi In-Soo , Lee Joong-Bok
Published: March 2023

N-linked glycans covering GP5 neutralizing epitopes of porcine reproductive and respiratory syndrome virus (PRRSV) have been proposed to act as a sheath blocking the production of neutralizing antibodies. Herein, we genetically engineered PRRSV with serine (S) substitution on the 44th asparagine (N) on the GP5 ectodomain of PRRSV-2 lineage-1. To evaluate the recombinant PRRSV, in vivo experiments were performed in piglets. The recombinant virus group showed no viremia until 42 days post-inoculation (dpi), and the rectal temperature and average daily weight gain were in the normal range at the same time point as the negative control group. On the 42 dpi, both groups were challenged with the wild-type virus. The recombinant PRRSV group showed lower rectal temperature, viremia, and the lung lesions than that of the negative control group for 19 days post-challenge (dpc). Additionally, the recombinant virus induced 4.50 ± 3.00 (log2) and 8.25 ± 0.96 (log2) of neutralizing antibody before and after challenge, respectively. Taken together, this study confirmed that N44S substitution can create an infectious PRRSV that strongly induces neutralizing antibodies. In addition, the vCSL1-GP5-N44S mutant that we produced was confirmed to have potential as a vaccine candidate, showing good safety and protective effects in pigs.
The Use of Simulation Models and Student-Owned Animals for Teaching Clinical Examination Procedures in Veterinary Medicine
Authors: Marcos Ricardo , Macedo Sónia , de Vega Macamen , Payo-Puente Pablo
Published: March 2023

Clinical examination procedures (CEPs) are cornerstone clinical skills for veterinary practitioners, being taught in all veterinary faculties. CEPs include innocuous procedures that are well tolerated by animals as well as more distressful and less tolerated ones. In a classical approach, institutional animals are used to teach and practice CEPs. Two hundred and thirty-one undergraduate students from four consecutive years were assigned to two groups that used institutional animals only (AO) or a combination of students’ owned animals and simulation models (model–animal, MA) to teach and practice CEPs. This latter comprised stuffed teddy dogs, eye and ear models made of molding silicone, as well as skin models. The learning outcome of each system was compared through questionnaires (throughout classes and at the end of course), grades, and pass rates in objectively structured clinical examinations. Most veterinary students had their own animals, being easy to have a dog per group of two students in class. All the students’ owned animals adapted well to this environment. The interest in the practical activities with the simulation models was comparable to that exhibited in the classical AO system. Students reported to learn more with the MA system than with the AO, while the interest on the subjects and the relevance were appraised similarly in both systems. No differences existed in the final grades and pass rates. The MA system was effective for learning CEPs. Beyond animal welfare advantages, this system increased the out-of-school training and had financial saving benefits, being a valuable option for the teaching and training of CEPs.
Chironomid-Based Modern Summer Temperature Data Set and Inference Model for the Northwest European Part of Russia
Authors: Nazarova Larisa , Syrykh Liudmila , Grekov Ivan , Sapelko Tatiana , Krasheninnikov Andrey B. , Solovieva Nadia
Published: March 2023

Northwestern Russia remains the only region in Northern Eurasia where no regional chironomid-based inference model for quantitative palaeoclimatic reconstructions has been developed. Using palaeolimnological methods, we investigated the subfossil chironomid remains in surface sediments from a data set of 98 lakes from nine subregions of the European part of Northern Russia. We identified 143 chironomid taxa in the investigated lakes. Multivariate statistical analyses of chironomid and environmental data demonstrated that the mean July air temperature (T July), distance from the tree line, water depth, pH, and altitude explain the most significant variance in chironomid distribution. T July appeared to be the most important environmental variable. We established a chironomid-based inference model for reconstructing T July from subfossil data. The resulting West Russian two-component WA-PLS model includes 96 lakes (two lakes were excluded as outliers), 143 chironomid taxa, r2 = 0.84 (r2 boot = 0.60), RMSEP boot = 1.34 °C, and can be recommended for application in palaeoclimatic studies in the East of Northern Eurasia.
Performance, Modeling, and Cost Analysis of Chemical Coagulation-Assisted Solar Powered Electrocoagulation Treatment System for Pharmaceutical Wastewater
Authors: Al-Zghoul Tharaa M. , Al-Qodah Zakaria , Al-Jamrah Ahmad
Published: March 2023

The combination of the chemical coagulation-assisted electrocoagulation (CC-EC) process with a solar photovoltaic energy source has attracted increasing attention for the efficient removal of chemical oxygen demand (COD) from pharmaceutical wastewater. In this paper, the CC-EC process has been utilized as an alternative to conventional chemical processes for the treatment of pharmaceutical wastewater. The effects of the various operating parameters, such as coagulant dosage, coagulant type, number of electrodes, the distance between electrodes, electrode configuration, operating time, and current density, on COD removal efficiency were investigated. The results indicated that the optimum conditions were achieved at 500 mg/L of alum dosage, 3.105 mA/cm2 of current density, six electrodes with a distance of 4 cm between electrodes, and the MP-S electrode configuration, where the operating cost of conventional energy was 0.283 $/m3. Indeed, by using the CC process alone, the COD removal efficiency was 26% and 61.5% at the optimal dosages of 750 mg/L of NaOH and 500 mg/L of alum, respectively. In the CC-EC treatment, the removal efficiencies of COD were 88.7, 92.9, 94.4, and 89.4% using six electrodes, 2 cm of distance between electrodes, MP-S electrode configuration, and 20 min with 1.553 mA/cm2 of current density, respectively. The removal efficiencies of COD achieved through CC, EC, and CC-EC processes were 61.5, 85.4, and 94.4%, respectively.
Aquavoltaics Feasibility Assessment: Synergies of Solar PV Power Generation and Aquaculture Production
Authors: Imani Moslem , Fakour Hoda , Lo Shang-Lien , Yuan Mei-Hua , Chen Chih-Kuei , Mobasser Shariat , Muangthai Isara
Published: March 2023

The negative effects of climate change have burdened humanity with the necessity of decarbonization by moving to clean and renewable sources of energy generation. While energy demand varies across the sectors, fisheries, including fishing and aquaculture, are among the most energy intensive processes in the food production industry. The synergistic opportunities for co-located aquaculture and renewable energy can thus provide a multifunctional use of space and resources, creating opportunities to meet the identified energy demands of a variety of aquaculture operations. This study has investigated a sustainable energy model for a small-scale shrimp farm in western Taiwan with synergies for the dual use of the water area for solar photovoltaic electricity generation and aquaculture. Based on the simulation results and SWOT analysis, recommendations have been made for the design and operation of a solar-powered aeration system for shrimp farms. The average monthly energy production of 32 MWh is attainable at the estimated canopy space on a carport by installing 896 solar modules on the proposed site, fully covering the power demand of the shrimp farm. These findings have significance for encouraging effective practices in deploying solar techniques in aquaculture and making them replicable in global settings.
Impact of a Sand Filtration Pretreatment Step on High-Loaded Greywater Treatment by an Electrocoagulation Technique
Authors: Bani-Melhem Khalid , Bsoul Abeer Al , Al-Qodah Zakaria , Al-Ananzeh Nada , Al-Kilani Muhammad Rasool , Al-Shannag Mohammad , Bani-Salameh Walid
Published: March 2023

Greywater (GW) treatment by the electrocoagulation (EC) technique alone might not meet the required standards in terms of pollutant removal, specifically when GW contains high loads of pollutants. In this preliminary study, a sand filtration (SF) unit was integrated with the EC technique as a pretreatment step to enhance the EC process for treating high-loaded GW. Three different voltage gradients were investigated (5 V/cm, 10 V/cm, and 15 V/cm) in the EC unit. The results demonstrated that the pretreatment SF step can contribute significantly to reducing pollutant concentrations in the greywater to be treated by EC. In terms of physical impurities, the results showed that the SF pretreatment step reduced the turbidity and the color of the treated GW by 28.4%, and 9.4%, respectively. The COD concentration was reduced by 25.5% by the SF step, which allowed a reduction of EC steady state time in the EC unit from 45 min to 30 min at an applied voltage of 15 V/cm. In addition, a high COD removal rate of 87.8% from high-load greywater was achieved with an energy consumption of only 4.11 kWh/m3 in comparison with 6.21 kWh/m3 without the SF step, which is equivalent to a 34% saving in energy consumption.
Successive-Station Streamflow Prediction and Precipitation Uncertainty Analysis in the Zarrineh River Basin Using a Machine Learning Technique
Authors: Nakhaei Mahdi , Ghazban Fereydoun , Nakhaei Pouria , Gheibi Mohammad , Wacławek Stanisław , Ahmadi Mehdi
Published: March 2023

Precise forecasting of streamflow is crucial for the proper supervision of water resources. The purpose of the present investigation is to predict successive-station streamflow using the Gated Recurrent Unit (GRU) model and to quantify the impact of input information (i.e., precipitation) uncertainty on the GRU model’s prediction using the Generalized Likelihood Uncertainty Estimation (GLUE) computation. The Zarrineh River basin in Lake Urmia, Iran, was nominated as the case study due to the importance of the location and its significant contribution to the lake inflow. Four stations in the basin were considered to predict successive-station streamflow from upstream to downstream. The GRU model yielded highly accurate streamflow prediction in all stations. The future precipitation data generated under the Representative Concentration Pathway (RCP) scenarios were used to estimate the effect of precipitation input uncertainty on streamflow prediction. The p-factor (inside the uncertainty interval) and r-factor (width of the uncertainty interval) indices were used to evaluate the streamflow prediction uncertainty. GLUE predicted reliable uncertainty ranges for all the stations from 0.47 to 0.57 for the r-factor and 61.6% to 89.3% for the p-factor.
Variable Switching Frequency Deadbeat Predictive Current Control for PMSM with High-Speed and Low-Carrier Ratio
Authors: Wang Zhiqiang , Wang Chenyu , Liang Haishen , Han Zhuangzhuang , Jin Xuefeng , Zhang Guozheng
Published: March 2023

The predictive current control method of permanent magnet synchronous motor has the advantages of fast dynamic response and easy digital implementation, so more attention has been paid to it. When the motor operates in a high-speed condition, the switching frequency is relatively low, the carrier ratio is low, and the rotor angle varies greatly within a control cycle, resulting in a large error in the traditional liner approximation prediction model and inaccuracy of the voltage control quantity calculation, which leads to the deterioration of the predictive current control effect. At the same time, the output harmonic of the three-phase current increases, which affects the stable operation of the motor. In this paper, we study the causes of the large errors in the prediction model based on the traditional linear approximation and phase current fluctuation of the permanent magnet synchronous motor under high speed and low carrier-ratio conditions. Based on the improvement of the prediction model and modulation, a new control strategy of variable switching frequency deadbeat predictive current control is proposed. The control method proposed in this paper improves the dynamic and steady-state performance of the motor, under the condition that the carrier ratio does not increase and reduces the fluctuation of the output current of the motor. Finally, the effectiveness and superiority of the proposed method are verified by an experiment.
A Parameter-Free Method for Estimating the Stator Resistance of a Wound Rotor Synchronous Machine
Authors: Haghgooei Peyman , Jamshidpour Ehsan , Corne Adrien , Takorabet Noureddine , Khaburi Davood Arab , Baghli Lotfi , Nahid-Mobarakeh Babak
Published: March 2023

This paper presents a new online method based on low frequency signal injection to estimate the stator resistance of a Wound Rotor Synchronous Machine (WRSM). The proposed estimator provides a parameter-free method for estimating the stator resistance, in which there is no need to know the values of the parameters of the machine model, such as the stator and rotor inductances or the rotor flux linkage. In this method, a low frequency sinusoidal current is injected in the d axis of the stator current to produce a sinusoidal flux in the stator. In this paper, it is shown that the phase difference between the generated sinusoidal flux and the injected sinusoidal current is related to the stator resistance mismatch. Using this phase difference, the stator resistance is estimated. To validate the proposed model-free estimator, simulations were performed with Matlab Simulink and the results were compared with the extended Kalman filter observer. Finally, experimental tests, under different conditions, were performed to estimate the stator resistance of a WRSM.
Development of acute peptic ulcers complicated by gastrointestinal bleeding in patients with novel coronavirus infection
Authors:   Berbekov Kabardino-Balkarian State University, Nalchik, Russian Federation, Musukaeva A. B. , Miziev I. A. ,   Berbekov Kabardino-Balkarian State University, Nalchik, Russian Federation, Ivanova Z. O. ,   Berbekov Kabardino-Balkarian State University, Nalchik, Russian Federation, Ahkubekov R. A. ,   Berbekov Kabardino-Balkarian State University, Nalchik, Russian Federation, Achabaeva A. B. ,   Berbekov Kabardino-Balkarian State University, Nalchik, Russian Federation, Zhilova M. M. ,   Berbekov Kabardino-Balkarian State University, Nalchik, Russian Federation
Published: March 2023

The study enrolled patients with acute gastrointestinal ulcers and gastrointestinal bleeding, EGD confirmed, against the background of the novel coronavirus infection (61 patients). There were 39 men (63.9 %), women — 22 (36.1 %), the mean age of the patients was 57 years. It was found that preventive schemes of acid blockers administration have not been sufficiently effective and is unsafe for the patients with COVID-19. Based on this, as a prevention of the acute gastrointestinal ulcers in patients with the novel coronavirus infection without GI bleeding, we recommend the administration of the H2 receptor antagonists. The risk of gastrointestinal bleeding increases in patients with COVID-19, so there is a need for further investigation of the efficacy and safety of the preventive therapy in this category of patients.
Co-existence of intraductal papillary neoplasm of the bile duct and opisthorchiasis: a clinical case
Authors:   1FSBI National Medical Research Center of Surgery named after A. Vishnevsky of the Ministry of Health of Russia, Moscow, Trifonov S. A. , Kovalenko Yu. A. ,   1FSBI National Medical Research Center of Surgery named after A. Vishnevsky of the Ministry of Health of Russia, Moscow, Savelieva T. V. ,   1FSBI National Medical Research Center of Surgery named after A. Vishnevsky of the Ministry of Health of Russia, Moscow, Glotov A. B. ,   1FSBI National Medical Research Center of Surgery named after A. Vishnevsky of the Ministry of Health of Russia, Moscow, Gurmikov B. N. ,   1FSBI National Medical Research Center of Surgery named after A. Vishnevsky of the Ministry of Health of Russia, Moscow, Chzhao A. V. ,   2European Medical Center, Moscow, Chugunov A. O. ,   3FSAEI HE N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow
Published: March 2023

This article presents a clinical case of a patient with an intestinal type of intraductal papillary neoplasm of the bile duct (IPNB). This case is interesting due to the fact that during the histological examination of the macropreparation in the bile ducts, flatworms of the genus Opisthorchis were found in addition to neoplasm elements.
Uso de las TIC en cuentos tradicionales y niveles de logro en la comprensión oral en niños de la zona Lago-Puno
Authors: García Bedoya Nancy Mónica , Zela Payi Nelly Olga , Velezvía Estrada Pierina Sadith
Published: March 2023

La investigación aborda el desarrollo de la comprensión oral en el niño, a partir del uso de videos con cuentos tradicionales, cuyo objetivo fue determinar los niveles de comprensión con el uso de las TIC en niños y niñas de la zona lago de Puno, el enfoque de investigación fue el cuantitativo, diseño cuasi experimental con pre y posprueba, con una población de trece niños de 5 años, los resultados obtenidos de la Prueba Estadística Chi Cuadrada, es que el nivel de comprensión oral en el grupo experimental para la prueba de salida es mayor a la prueba de entrada en los niños de la zona Lago de Puno, a un nivel de significancia del 0.05. Por lo cual se demuestra que existe influencia directa entre los cuentos tradicionales con el uso de las TIC y el nivel de logro de la comprensión oral en el niño.
Justicia y territorialidad en la visita de Toledo al repartimiento de Sipesipe (Cochabamba, Charcas, Siglo XVI)
Authors: Quiroga Daniel Oscar
Published: March 2023

En este trabajo se propone una aproximación a la Visita General (1570-1575) ordenada por el virrey Francisco de Toledo como instancia de administración de justicia y reconfiguración territorial. Para ello, se procede al estudio de caso de la visita realizada al repartimiento de indios de Sipesipe (Cochabamba, Charcas) por parte de Diego Núñez Bazán. Primeramente, se examinan los litigios iniciados por los indígenas, en el marco de la visita general, para conseguir la restitución de tierras ocupadas por españoles. Luego, se avanza en un análisis de la actuación del Visitador general, en tanto agente de justicia, para dirimir estos pleitos. Finalmente, se consideran los efectos que las resoluciones de Núñez Bazán y la política toledana tuvieron sobre el territorio cochabambino.
Un sumario para el malón. Fortín Arévalo, 1859.
Authors: Cordero Guido , Literas Luciano
Published: March 2023

A partir de un malón sobre el fortín Arévalo -ubicado en Saladillo- ocurrido en 1859 y el sumario instruido para determinar la respuesta de los funcionarios político-militares de esa frontera, este trabajo describe un proceso de investigación sobre la historia indígena de la segunda mitad del siglo XIX, en las Pampas. Simultáneamente a la exposición de las reflexiones y decisiones metodológicas elaboradas, el manuscrito anuda procesos asociados a la guerra civil, la política indígena y las dinámicas interétnicas, incorporando lo sucedido en el mencionado fortín en una explicación más amplia. El resultado es la reconstrucción de las conexiones, elusivas en las fuentes analizadas, entre actores y hechos de diferentes espacios y coyunturas que contribuye no solo al análisis del malón sobre el fortín Arévalo y la conflictividad interétnica enel oeste bonaerense, sino también al de la historia política de las sociedades indígenas y de la sociedad de frontera.
El estudio del teatro griego clásico: la importancia de la evidencia arqueológica
Authors: Reznik Carolina
Published: March 2023

El teatro como fenómeno artístico y como objeto de estudio es fascinante. Como toda actividad performativa, se manifiesta de manera completa en ese instante único y efímero que es la representación teatral. Además de esta característica, el espectáculo teatral está integrado por sistemas significantes de naturaleza disciplinar diversa, la cual -a su vez- se modifica en el conjunto. A la hora de encarar una investigación acerca del teatro en general y del teatro del pasado en particular, es indispensable evidenciar estas problemáticas para no incurrir en simplificaciones.

El presente artículo tiene como objetivo presentar las fuentes disponibles para el estudio del teatro griego clásico[1], tanto materiales como documentales, discutir sus características y destacar sus aportes. La propuesta consiste en mostrar el abanico completo y desmontar la hegemonía que han ostentado las fuentes literarias a lo largo de la historia. Antes de ahondar en ello, presentaremos algunas cuestiones vinculadas con la naturaleza del teatro y con la metodología para su estudio.  

 

[1] Por Época Clásica se denomina tradicionalmente al periodo comprendido entre la revuelta de Jonia en el año 499 A.E.C. (Antes de la Era Común, designación temporal convencional en arqueología clásica equivalente a a.C., antes de Cristo) -año en el que finaliza la Época Arcaica- y el comienzo del reinado de Alejandro Magno en 336 A.E.C. -año en el que se inaugura el período Helenístico-.
La danza contemporánea de la ciudad de buenos aires y su “poética del desencanto”
Authors: Clavin Ayelén
Published: March 2023

Una parte de las obras de danza contemporánea escénica de la ciudad de Buenos Aires condensa una serie de rasgos que corresponden a formas específicas de inclusión e irrupción de lo real, y configuran una escenicidad desencantada. El denominador común en estas obras es el desencanto, que tiende a suspender o fracturar la ilusión. Según lo definimos en estas páginas, el desencanto da cuenta de una particular interdependencia entre las puestas escénicas y el contexto en el que se crean, en tanto las piezas incluyen, o bien referencias explícitas, o bien marcas, huellas, de las circunstancias de producción y del trabajo de sus creadores/as. En las obras se repiensan y se ensayan alternativas posibles para la relación entre las creaciones, lxs artistas y lxs espectadores/as. Por último, el desencanto implica modos de estar en escena en los que los cuerpos son sede de lo real, es decir, son ese intersticio entre lo “extraescénico” y lo “intraescénico”[1] del trabajo implicado en estas prácticas dancísticas (crear, producir, interpretar, bailar).

 

[1] Las comillas responden a que, tanto lo extraescénico como lo intraescénico, experimentan un grado de permeabilidad tal, en los casos analizados, que hace difícil definir tajantemente si determinados elementos pertenecen a “dentro” o “fuera”.
Los carniceros de la lírica
Authors: Libonati Adriana , Rellán Valeria
Published: March 2023

El grupo estable Periplo, Compañía Teatral nace hace veintisiete años tras la búsqueda de importantes metas teatrales, desarrollar el trabajo actoral en sus dobles facetas textuales: (cuerpo y discurso del habla), y el oficio del director como colaborador en la armonización de esos parágrafos dentro de una poética. La técnica del grupo emana de un entrenamiento inherente a un programa de trabajo que constitutivamente procuraba reactualizarlo, y la configuración de un lenguaje estético propio[1]. En 2020 cumplieron 25 años de trabajo ininterrumpido; entrenamiento, obras, clases, viajes, lecturas compartidas o individuales, en la gestión de su espacio: El Astrolabio Teatro.

 

[1] Rellá, V. (Octubre 2017) Entrevista con el grupo .
Filosofia e ética: contribuições epistemológicas para a construção do conhecimento científico
Authors: De Barros Igor Silva , Monteiro-Santos Roseane , De Lima Alexsania Araújo , de Sousa Nilsoncley Borges , Dutra Gisélia dos Santos , Da Rocha Junior Olavo Raimundo de Macedo Barreto , Da Silva Jennifer Ranieri , Pinheiro Ionara Conceição Lemos , Araújo Amanda Jennifer , de Sousa Maria do Perpétuo Socorro Silva , De Sousa Luciano Gomes , Silva Vanderlene Oliveira
Published: March 2023

A presente pesquisa apresenta uma análise epistemológica das contribuições ético-filosóficas para a construção do conhecimento científico. A Filosofia e a Ética, ao confrontar-se com a crise ou os problemas que assolam a humanidade, procuraram identificar a sua origem. A pesquisa bibliográfica demonstra, que ao conhecer os fatos e fenômenos, trazemos à luz do pensamento, possíveis caminhos em direção a possíveis soluções, através do expoente do conhecimento lógico, possibilitando refletir e compreender o mundo. Por fim, justifica-se na pauta de assuntos que tratam dos aspectos técnicos e profissionais tomados no ambiente acadêmicos de pesquisas e estudos de aprimoramento que o estudam e tomam desse fenômeno as paridades com a realidade observada no mundo contemporâneo.
Syncranial osteology of the Nine-Banded Armadillo, Dasypus novemcinctus, from south Brazil
Authors: Machado Fabio Pereira , Dornelles Jose Eduardo Figueiredo , Rausch Stella , Oliveira Róger Jean , Portela Priscila Rockenbach , Valente Ana Luísa Schifino
Published: March 2023

Several aspects of the bone morphology of armadillos have been investigated and used as taxonomic bases. The nined-banded armadillo, Dasypus novemcinctus, is the species of the genus that has the largest geographical distribution. Although is the most well-known armadillo species in its biology, skeletal studies are scarce and its original description is not detailed to permit accurate taxonomic revision including specimens from Southern end of Brazil. The objective of the present work was to provide a complete description of the synchranium of specimens from Pampa biome including areas located at south of Rio Grande do Sul State, Brazil. The bony elements were described in detail on the basis of thirty-two specimens prepared specifically for this study. In general, the shape of bones remained morphologically similar between adults of both sexes. The studied specimens differed morphologically from those of previous studies and from more northern regions. Differences were verified in the lateral border of the palatine bone, shape of the pterygoids bones,shape of the coanas, outline of foramen Magnum and of Tentorial process. The results obtained generated evidences that may contribute to future morphological and taxonomical studies including animals from Southern Brazil.
Suplementação de glutamina e seu benefício no tratamento do câncer: uma revisão integrativa
Authors: Da Silva Laís Gabrielly Santana , de Vasconcelos Brenda Hilary Avelino , Melo Giulia Emanuelle de Almeida , Xavier Letícia Lira , Da Silva Júnior Mauricy Francisco , Santos Sandrelly Mirely da Silva , Dourado Keila Fernandes , Dutra Cleiton Leonardo de Farias
Published: March 2023

A glutamina é um aminoácido que se encontra depletado em situações hipercatabólicas, como o câncer, e tem ganhado destaque em estudos, devido suas características imunomoduladoras e seu potencial uso como fonte energética para o crescimento tumoral. Em vista disso, o presente estudo teve por objetivo investigar os efeitos da suplementação de glutamina e seus benefícios no tratamento do câncer. As estratégias de busca foram realizadas com base nos artigos científicos publicados nas bases de dados disponibilizadas na plataforma PubMed entre os anos de 2012 e 2022 e nos idiomas português, espanhol e inglês. Foi obtido um total de cento e cinquenta e nove artigos, sendo todos no idioma inglês. Então, selecionou-se artigos científicos completos e originais e que continham os termos completos nos títulos ou resumos. Foram excluídos os artigos que não contemplassem o tema e os objetivos propostos no presente estudo. A partir da leitura dos títulos e resumos, foram excluídos cento e trinta e seis artigos, permanecendo vinte e três artigos para serem analisados na íntegra. Com base nos critérios de exclusão, dezessete foram descartados, restando seis artigos publicados para compor a amostra deste trabalho. Apesar de estudos teóricos e in vitro revelarem uma possível associação entre a glutamina e a capacidade de estimulação do crescimento tumoral e impacto negativo nos resultados do tratamento antineoplásico, os resultados encontrados neste estudo sugerem um papel benéfico do uso de suplementação de glutamina na melhora de parâmetros bioquímicos, biológicos e fisiológicos. Desse modo, recomenda-se que a glutamina seja revista no contexto do tratamento oncológico e futuramente avaliada a possibilidade de inclusão como parte do cuidado nesse perfil de pacientes, uma vez que, pode resultar em aumento na qualidade de vida.
Percepção da conduta do médico obstetra sobre saúde bucal
Authors: Santos Priscilla Pereira , Ferreira Cibelly de Fátima Vieira , Da Silva Lucas Daylor Aguiar , Brasil Mirla de Jesus dos Santos , Fonseca Ana Beatriz Duarte , Lima Gisele Quariguasi Tobias , Costa José Ferreira , Costa Elizabeth Lima
Published: March 2023

Objetivo: Avaliar a percepção e conduta do médico obstetra sobre saúde bucal no acompanhamento das gestantes, durante as consultas pré-natais na cidade de São Luís, Maranhão. Material e métodos: Trata-se de um estudo transversal, realizado com 41 médicos obstetras que prestam atendimento no Hospital/Maternidade de Alta Complexibiliadade de São Luís-MA. Os médicos responderam a um questionário estruturado contendo 20 perguntas relacionadas a saúde bucal no período gestacional. Resultados: Desta amostra, 58,5% médicos são do sexo masculino e 41,5% do sexo feminino; 56,1% tinham entre 29 e 49 anos; 41,5% entre 28 e 38 anos e 2,4% mais de 60 anos; 22% sempre aconselham as gestantes sobre saúde bucal e 51,2% a partir do 3º mês de gestação; todos os médicos receberam informações sobre saúde bucal. Conclusão: A relação entre médico obstetra e cirurgião dentista deve ser estreitada, contribuindo para um efetivo atendimento multidisciplinar das gestantes e dos bebês. Faz-se necessária uma maior atuação interdisciplinar, entre cirurgiões-dentistas e médicos dedicados ao acompanhamento da gestante, e que o cirurgião-dentista se integre, efetivamente, à equipe de atendimento pré-natal.
Pengabdian Kepada Masyarakat Kolaboratif, Holistik, Integratif, Kreatif & Inovatif di Kecamatan Sukaresmi
Authors: Watini Sri , Romdhonah Ratu , Suhayati Yati , Nurfaidah Nida , Sutarsih Esi , Sofiah Eva , HS Wawan
Published: March 2023

Kecamatan Sukaresmi termasuk desa tertinggal, ada beberapa poin yang menjadi fokus kegiatan dalam pembinaan terhadap lembaga yanga ada di kecamatan Sukaresmi, program yang kami laksanakan yaitun: Pendampingan dan Pelatihan Manajemen Administrasi, Bimbingan dan Pendampingan Pembuatan/ Penyusunan Proposal ijin Pendiriann dan Ijin Operasional, Sosoialisasi Pembelajaran Melalui TV Sekolah, Bimbingan Kegiatan Pembelajaran Mengenalkan Kearifan Budaya Lokal Pada Anak, Sosialisasi dan Penyuluhan Stunting Pada Lembaga PAUD dan Masyarakat Sekitar. Pendampingan dilakukan dengan menjalankan program sesuai kebutuhan lembaga dan desa setempat. Dari rangkaian kegiatan Pengabdian Kepada Masyarakat ini berupaya memberikan pendampingan sesuai dengan harapan para masyarakat, dari keseluruhan program tersebut dapat memberikan penguatan untuk meningkatkan potensi lokal daerah melalui pembelajaran di PAUD. Harapan besarnya yaitu anak usia dini saat ini dapat menjadi generasi muda yang berakhlaq, sehat, cerdas dan mengenal akar budaya mereka masing-masing, dapat mengembangkan potensi lokal daerah menjadi sumber pendapatan daerah. Sehingga tidak ada lagi desa termiskin dan tertinggal di Kabupaten Pandeglang.
PRECEDENTES JUDICIAIS – CONCEITOS RELEVANTES E INSTITUTOS CORRELATOS
Authors: Figueiredo Sotero VICTOR
Published: March 2023

This article aims to survey the concepts and institutes that integrate the Brazilian system of precedents, in order to ensure the application of this legal institute in a stable, integral and consistent way. This panorama is relevant especially after the changes promoted in the adjective provisions through Law n.13,105/2015, which innovated in the national system by fully revoking the previous codification, replacing it with the current Code of Civil Procedure. In this area, we seek to answer the following research question: How does the correct understanding of the concepts and institutes that integrate the Brazilian system of precedents ensure that the legal system is applied in a stable, integral and consistent way? With this, it is possible to realize that further academic study of the theme represents one of the ways of ensuring that what was problematized in the research is understood. Finally, it can be seen that the mastery of concepts and institutes regarding the issue of precedents brings to light the guarantee of maintaining stable, integral, and coherent jurisprudence, fulfilling a relevant role in the objective outlined in this research.
The Politics of Education and Learning in Vietnam: Contributions to a Theory of Embedded Accountabilities
Authors: London Jonathan D. , Duong Bich-Hang
Published: March 2023

This paper locates many of the most important strengths and weaknesses in Vietnam’s education system in the politics of education and in features of the country’s education system’s societal embedding. By the politics of education, we mean the relations of power and authority and of domination, contestation, cooperation, and accommodation that shape the functioning of the education system as an institutional field. By the societal embeddedness, we refer to the system’s interdependent relation with its broader social and institutional environment. Understanding these elements of Vietnam’s education system is of vital importance for efforts to improve education systems’ performance in Vietnam and beyond.
Hybrid Culture in Indonesian EFL Textbooks: Policies and Pedagogical Implications
Authors: Sapoetra Jimmy
Published: March 2023

Hybrid Culture is a new term which reflects the diversity and complexity of the world culture existing today. The term hybrid culture refers to the mixture of several kinds of culture blended or integrated into one new culture which has the characteristics of the old and new culture it represents. In the context of EFL learning in Indonesia, many EFL textbooks do not really cover the hybridity of the culture which creates the pedagogical implications in the future of education. The majority of the textbooks either focus on the local or target culture. They do not emphasize the importance of the students to understand that culture is not single-handedly original in its nature but consists of many external factors. This study attempts to examine  such a phenomenon. The data were taken from 3 (three) local EFL textbooks used in some high schools in Indonesia. The researcher uses the Content Analysis method with the cultural content evaluation by Byram and Morgan (1994) and Kilickaya (2004). They proposed a qualitative evaluation checklist with a list of criteria for examining the extent and methods of how culture is presented. There are nine categories from the checklist, namely- social identity and social groups, social interaction, belief and behavior, socio-political institutions, socialization and the life-cycle, national history, national geography, national cultural heritage, stereotypes and national identity (Byram & Morgan, 1994). Then the results were compared and it was found that the textbooks do not clearly represent the hybrid culture in their content.
Infecciones oportunistas de acuerdo con el conteo de linfocitos T CD4+ en pacientes con VIH en un centro de referencia terciaria
Authors: Aguilar-Molina Oswaldo Enrique , Vallejo Serna Raúl Andrés , Escobar Mera Maria Antonia , Barona Romy Daniel , Gartner Lopez Estefanía , Matta-Cortés Lorena
Published: March 2023

Las infecciones oportunistas (IO) han marcado el pronóstico en la evolución natural de los pacientes con infección por virus de inmunodeficiencia humana (VIH).

Objetivo: conocer las IO más frecuentes y establecer su relación con el conteo de linfocitos T CD4+ (LTCD4+) puede mejorar nuestra práctica clínica y favorecer un diagnóstico temprano, uso de terapias empíricas y tratamiento dirigido oportuno.

Material y métodos: estudio observacional, retrospectivo, con el propósito de describir las características y variaciones de las IO diagnosticadas por clínica, métodos directos o indirectos, que se desarrollan en los pacientes con VIH en relación con su conteo LTCD4+ que ingresan a una institución de tercer nivel de atención en Cali (Colombia). Se incluyeron pacientes adultos hospitalizados entre enero 2018 a enero 2019 con diagnóstico de infección por VIH/SIDA y con antecedente o IO al momento del ingreso; se excluyeron menores de 18 años y gestantes.

Resultados: se obtuvo una muestra de 190 pacientes con al menos una infección oportunista, del cual 65.3% eran hombres con una edad mediana de 37 años (29.0-46.0), para las mujeres de 35.5 años (31.2-43.0). El 83% se encontraba en clasificación C3 al ingreso, 86% con recuento de LTCD4+ ≤ 200 cels/mm3. De las IO las más frecuentes fueron, tuberculosis con 28.4%, neumocistosis con 27.9% y toxoplasmosis con 27.4%.

Conclusiones: en nuestra población, pese al avance y mayor disponibilidad de terapia antirretroviral de alta efectividad, la mayoría de los pacientes con infección por VIH se hospitalizan en estadios avanzados con infecciones oportunistas, en algunos casos dos o más de manera concomitante y con evidencia de compromiso virológico e inmunológico severo
Hepatitis autoinmune y esclerosis sistémica
Authors: Guzman Lopez Julieth Alexandra , Moreno Useche Luis David , Santamaría Alza Yeison , Lopez Aldana Jairo Enrique
Published: March 2023

La presencia de hepatitis autoinmune concomitante con otras enfermedades inmunomediadas es una condición de difícil diagnóstico que se ha reconocido cada vez mas. Presentamos el caso de una mujer de 42 años sin antecedentes de importancia, quien consulta por crecimiento progresivo de masa abdominal en hipocondrio derecho y síndrome constitucional asociado; al examen físico se evidencia hepatomegalia y hallazgos en piel de calcinosis, despigmentación en sal y pimienta, y fenómeno de Raynaud en manos, en los paraclínicos realizados con reporte de transaminasas elevadas, aumento de inmunoglobulina IgM, anticuerpos antinucleares (ANAS) y anticuerpos antimúsculo liso (SMA) positivos, junto con signos imagenológicos de hipertensión portal. Se realiza biopsia hepática compatible con hepatitis autoinmune, se inicia manejo con corticoides obteniendo una adecuada respuesta. La esclerosis sistémica es una de las enfermedades autoinmunes que pueden presentarse en un paciente con hepatitis autoinmune, su sospecha, diagnóstico y seguimiento en este tipo de pacientes configuran un punto clave en su abordaje integral.