bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation Capabilities and the Performance of Start-Ups in Korea: The Role of Government Support Policies
Authors: Choi Se-Kyoung , Han Sangyun , Kwak Kyu-Tae
Published: May 2021

What kind of capacity is needed to improve the performance of start-ups? How effective are government support policies in improving start-up performance? Start-ups are critical firm group for ensuring the prospective and sustainable growth of an economy, and thus many countries’ governments have established support policies and they are likely to engage more widely in forward-looking political support activities to ensure further growth and expansion. In this paper, the effect of innovation capabilities and government support policies on start-up performance is examined. We used an unbalanced panel data analysis with a random effect generalized least squares. We investigated the effect of government support policies on 4368 Korean start-ups. The findings indicated that technology and knowledge capabilities had positive effects on the sales performance of start-ups, and government financial support positively affected the relationship between knowledge capability and firm performance. However, when government financial support increased, marketing capability was negatively associated with firm performance. These results demonstrate the significant role of government financial support, including its crowding in but also its crowding out effect. Practical implications: To be more effective, governments should employ innovation-driven entrepreneurship policy approaches to support start-ups. To improve their performance, start-ups need to increase their technology and knowledge capabilities. This study extends recent efforts to understand more fully the effect of government support policies on start-ups differing in their technology, knowledge, and marketing capabilities.
Whole Fish Powder Snacks: Evaluation of Structural, Textural, Pasting, and Water Distribution Properties
Authors: Nawaz Asad , Khalifa Ibrahim , Walayat Noman , Lorenzo Jose M. , Irshad Sana , Abdullah  , Ahmed Shakeel , Simirgiotis Mario Juan , Ali Madad , Li Enpeng
Published: May 2021

Global fisheries production has increased up to ~200 MT, which has resulted in the intensive generation of waste or byproducts (~20 MT), which is creating serious problems for environmental management with zero income. This study proposes an idea of using whole fish (red and white meat, skin, bones, and fins but not scales) for human food (snack food) with the aim of zero waste generation. Whole fish powder (WFP) was prepared by a novel method (using freeze-drying as well as stone ball milling) and fortified in baked snacks at four levels (0, 5, 10, and 15% w/w of 100 g of formulation). The results revealed that the addition of WFP decreased expansion and color parameters compared to control. Hardness was significantly (p < 0.05) increased with the addition of WFP, which was attributed to the mineral content of WFP. Pasting properties determined by rapid visco analyzer (RVA) were dramatically decreased with the addition of 10–15% WFP, suggesting the weak interaction of starch and protein, which was also evidenced by scanning electron microscopy (SEM). Low field nuclear magnetic resonance (LF-NMR) analysis revealed that the amount of free water was increased when 10–15% WFP was added in snacks while bound water was highest in control and 5% WFP samples, respectively. The microstructural analysis by SEM showed that the protein network was increased in those samples incorporated with WFP compared to control that had more starch granules. The results suggest the feasibility of adding 5% WFP for proper structure, texture, pasting properties, and water distribution in order to reduce fish waste.
Sustainability Indicators in a Bachelor’s Educational Program in the Health Area
Authors: Brito Rosa María , Aparicio José Luis , Rodríguez Columba , Beltrán Juana
Published: May 2021

Superior education institutions are interested in training human resources with a holistic and critical vision, which contribute to the attention of environmental problems from the health area. The objective was to analyze, with indicators and indexes, the achievement reached regarding the level of sustainability in the functions of directors, teachers, and students at the Superior School of Nursing No. 1 of the Autonomous University of Guerrero, Mexico. The methodology was quantitative; interviews were applied to three directors, and surveys to 18 teachers and 226 students. On environmental issues, the findings show that teachers have scarce knowledge, with 14%; directors vary significantly, registering 58%; meanwhile, students are located at 60%. In the social indicator, students had 66%, directors 64%, and teachers 31%; the economic indicator was the least valued with 41% for students, 40% for directors, and 15% for teachers. The sustainability index for teachers was 0.19%, in “collapse”; for directors and students, it was “unstable”, with 0.56% and 0.58%, respectively. It was concluded that teachers prioritize disciplinary content; students express greater concern, knowledge, and interest for the environment.
A Method for the Automated Construction of 3D Models of Cities and Neighborhoods from Official Cadaster Data for Solar Analysis
Authors: Beltran-Velamazan Carlos , Monzón-Chavarrías Marta , López-Mesa Belinda
Published: May 2021

3D city models are a useful tool to analyze the solar potential of neighborhoods and cities. These models are built from buildings footprints and elevation measurements. Footprints are widely available, but elevation datasets remain expensive and time-consuming to acquire. Our hypothesis is that the GIS cadastral data can be used to build a 3D model automatically, so that generating complete cities 3D models can be done in a short time with already available data. We propose a method for the automatic construction of 3D models of cities and neighborhoods from 2D cadastral data and study their usefulness for solar analysis by comparing the results with those from a hand-built model. The results show that the accuracy in evaluating solar access on pedestrian areas and solar potential on rooftops with the automatic method is close to that from the hand-built model with slight differences of 3.4% and 2.2%, respectively. On the other hand, time saving with the automatic models is significant. A neighborhood of 400,000 m2 can be built up in 30 min, 50 times faster than by hand, and an entire city of 967 km2 can be built in 8.5 h.
Large-Scale Geothermal Collector Systems for 5th Generation District Heating and Cooling Networks
Authors: Zeh Robin , Ohlsen Björn , Philipp David , Bertermann David , Kotz Tim , Jocić Nikola , Stockinger Volker
Published: May 2021

Low temperature district heating and cooling networks (5GDHC) in combination with very shallow geothermal energy potentials enable the complete renewable heating and cooling supply of settlements up to entire city districts. With the help of 5GDHC, heating and cooling can be distributed at a low temperature level with almost no distribution losses and made useable to consumers via decentralized heat pumps (HP). Numerous renewable heat sources, from wastewater heat exchangers and low-temperature industrial waste heat to borehole heat exchangers and large-scale geothermal collector systems (LSC), can be used for these networks. The use of large-scale geothermal collector systems also offers the opportunity to shift heating and cooling loads seasonally, contributing to flexibility in the heating network. In addition, the soil can be cooled below freezing point due to the strong regeneration caused by the solar irradiation. Multilayer geothermal collector systems can be used to deliberately generate excessive cooling of individual areas in order to provide cooling energy for residential buildings, office complexes or industrial applications. Planning these systems requires expertise and understanding regarding the interaction of these technologies in the overall system. This paper provides a summary of experience in planning 5GDHC with large-scale geothermal collector systems as well as other renewable heat sources.
Integrated Operational Model of Green Closed-Loop Supply Chain
Authors: Chiu Chui-Yu , Cheng Chen-Yang , Wu Ting-Ying
Published: May 2021

Due to increasing environmental awareness, companies have started embracing the green supply chain concept to reduce waste of resources. Based on this increased awareness, an integrated green closed-loop supply chain has been developed, which integrates the forward supply chain and reverse supply chain. The reverse supply chain follows the same path as the forward supply chain in the reverse direction to recycle used products. Due to the uncertain quality of used products, not all products can be selected for recycling and reproduction, as the reduced yield might decrease the overall net income in the supply chain. The study develops an evaluation model to consider government subsidy, used product recycling rate, and quality of the used products to explore their impacts on the entire system. The results show that when the reproducibility rate of used raw materials decreases, the net income would also decrease accordingly. Furthermore, when government subsidy increases, the net income of the supply chain also increases accordingly. Similarly, when the recycling rate of used products increases, the net income also increases. As government subsidy affects the net income more than the recycling rate of used products, this research concludes that government subsidy is a key factor in the green closed-loop supply chain.
Risk Management in the Import/Export Process of an Automobile Company: A Contribution for Supply Chain Sustainability
Authors: Dias Gabriela Costa , de Oliveira Ualison Rébula , Lima Gilson Brito Alves , Fernandes Vicente Aprigliano
Published: May 2021

Supply chain risk management (SCRM) is imperative to achieve business sustainability in the long-term perspective and also to increase companies’ competitiveness. ISO 31000—Risk Management explains in its latest versions the need for companies to integrate a risk management process into their business models. Complementary to this standard, ISO 31010 presents 31 risk tools to guide companies in this task. However, a question of practical application arises as to which tools should be used for each stage of the SCRM process. In view of the raised question, the main objective of this research is to select ISO 31010 tools that can be used in each of the stages (identify, analyze, and evaluate) of the risk management of the import and export process of an automotive industry located in Brazil. For this, the analytic hierarchy process (AHP method) was used in a case study to prioritize the tools to compose the SCRM. As practical implications, this study resulted in the suggestion of a structured risk management process, considering the assessment of key professionals of the department studied in the company.
Analysis of the Internal Structure of Hadrons Using Direct Photon Production
Authors: Rentería-Estrada David Francisco , Hernández-Pinto Roger José , Sborlini German
Published: May 2021

Achieving a precise description of the internal structure of hadrons is crucial for deciphering the hidden properties and symmetries of fundamental particles. It is a hard task since there are several bottlenecks in obtaining theoretical predictions starting from first principles. In order to complement highly accurate experiments, it is necessary to use ingenious strategies to impose constraints from the theory side. In this article, we describe how photons can be used to unveil the internal structure of hadrons. We explore how to describe NLO QCD plus LO QED corrections to hadron plus photon production at colliders and discuss the impact of these effects on the experimental measurements.
Einstein–Gauss–Bonnet Gravity with Nonlinear Electrodynamics: Entropy, Energy Emission, Quasinormal Modes and Deflection Angle
Authors: Kruglov Sergey Il’ich
Published: May 2021

The logarithmic correction to Bekenshtein–Hawking entropy in the framework of 4D Einstein–Gauss–Bonnet gravity coupled with nonlinear electrodynamics is obtained. We explore the black hole solution with the spherically symmetric metric. The logarithmic term in the entropy has a structure similar to the entropy correction in the semi-classical Einstein equations. The energy emission rate of black holes and energy conditions are studied. The quasinormal modes of a test scalar field are investigated. The gravitational lensing of light around BHs was studied. We calculated the deflection angle for some model parameters.
Preparation and Characterization of Monoclonal Antibodies with High Affinity and Broad Class Specificity against Zearalenone and Its Major Metabolites
Authors: Wang Yanan , Wang Xiaofei , Zhang Haitang , Fotina Hanna , Jiang Jinqing
Published: May 2021

This study aimed to detect and monitor total Zearalenone (ZEN) and its five homologs (ZENs) in cereals and feed. The monoclonal antibodies (mAbs) with a high affinity and broad class specificity against ZENs were prepared, and the conditions of a heterologous indirect competitive ELISA (icELISA) were preliminarily optimized based on the ZEN mAbs. The immunogen ZEN-BSA was synthesized using the oxime active ester method (OAE) and identified using infrared (IR) and ultraviolet (UV). The coating antigen ZEN-OVA was obtained via the 1,4-butanediol diglycidyl ether method (BDE). Balb/c mice were immunized using a high ZEN-BSA dose with long intervals and at multiple sites. A heterologous indirect non-competitive ELISA (inELISA) and an icELISA were used to screen the suitable cell fusion mice and positive hybridoma cell lines. The ZEN mAbs were prepared by inducing ascites in vivo. The standard curve was established, and the sensitivity and specificity of the ZEN mAbs were determined under the optimized icELISA conditions. ZEN-BSA was successfully synthesized at a conjugation ratio of 17.2:1 (ZEN: BSA). Three hybridoma cell lines, 2D7, 3C2, and 4A10, were filtered, and their mAbs corresponded to an IgG1 isotype with a κ light chain. The mAbs titers were between (2.56 to 5.12) × 102 in supernatants and (1.28 to 5.12) × 105 in the ascites. Besides, the 50% inhibitive concentration (IC50) values were from 18.65 to 31.92 μg/L in the supernatants and 18.12 to 31.46 μg/L in the ascites. The affinity constant (Ka) of all of the mAbs was between 4.15 × 109 and 6.54 × 109 L/mol. The IC50 values of mAb 2D7 for ZEN, α-ZEL, β-ZEL, α-ZAL, β-ZAL and ZAN were 17.23, 16.71, 18.27, 16.39, 20.36 and 15.01 μg/L, and their cross-reactivities (CRs, %) were 100%, 103.11%, 94.31%, 105.13%, 84.63%, and 114.79%, respectively, under the optimized icELISA conditions. The limit of detection (LOD) for ZEN was 0.64 μg/L, and its linear working range was between 1.03 and 288.55 μg/L. The mAbs preparation and the optimization of icELISA conditions promote the potential development of a rapid test ELISA kit, providing an alternative method for detecting ZEN and its homologs in cereals and feed.
The Search for the Universality Class of Metric Quantum Gravity
Authors: Martini Riccardo , Ugolotti Alessandro , Zanusso Omar
Published: May 2021

On the basis of a limited number of reasonable axioms, we discuss the classification of all the possible universality classes of diffeomorphisms invariant metric theories of quantum gravity. We use the language of the renormalization group and adopt several ideas which originate in the context of statistical mechanics and quantum field theory. Our discussion leads to several ideas that could affect the status of the asymptotic safety conjecture of quantum gravity and give universal arguments towards its proof.
Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients
Authors: Ye Xunyan , Iwuchukwu Obinna P. , Avadhanula Vasanthi , Aideyan Letisha O. , McBride Trevor J. , Henke David M. , Patel Kirtida D. , Piedra Felipe-Andres , Angelo Laura S. , Shah Dimpy P. , Chemaly Roy F. , Piedra Pedro A.
Published: May 2021

Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants, the elderly, and immunocompromised patients. RSV antibodies play a role in preventing reinfection and in clearance of RSV, but data regarding the levels of viral protein-specific antibodies elicited and their contribution to patient recovery from RSV-induced disease are limited. We prospectively enrolled a cohort of RSV-infected adult hematopoietic cell transplant (HCT) recipients (n = 40). Serum and nasal-wash samples were obtained at enrollment (acute samples) and convalescence (convalescent samples). We measured (1) humoral IgG and mucosal IgA binding antibody levels to multiple RSV proteins (F, G, N, P, and M2-1) by Western blot (WB); (2) neutralizing antibody (Nt Ab) titers by microneutralization assay; and (3) palivizumab-like antibody (PLA) concentrations by an ELISA-based competitive binding assay developed in the lab. Finally, we tested for correlations between protein-specific antibody levels and duration of viral shedding (normal: cleared in <14 days and delayed: cleared ≥14 days), as well as RSV/A and RSV/B subtypes. Convalescent sera from HCT recipients had significantly higher levels of anti-RSV antibodies to all 5 RSV structural proteins assayed (G, F, N, P, M2-1), higher Nt Abs to both RSV subtypes, and higher serum PLAs than at enrollment. Significantly higher levels of mucosal antibodies to 3 RSV structural proteins (G, N, and M2-1) were observed in the convalescent nasal wash versus acute nasal wash. Normal viral clearance group had significantly higher levels of serum IgG antibodies to F, N, and P viral proteins, higher Nt Ab to both RSV subtypes, and higher PLA, as well as higher levels of mucosal IgA antibodies to G and M2-1 viral proteins, and higher Nt Ab to both RSV subtypes compared to delayed viral clearance group. Normal RSV clearance was associated with higher IgG serum antibody levels to F and P viral proteins, and PLAs in convalescent serum (p < 0.05). Finally, overall antibody levels in RSV/A- and/B-infected HCT recipients were not significantly different. In summary, specific humoral and mucosal RSV antibodies are associated with viral clearance in HCT recipients naturally infected with RSV. In contrast to the humoral response, the F surface glycoprotein was not a major target of mucosal immunity. Our findings have implications for antigen selection in the development of RSV vaccines.
The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity
Authors: Grewe Bastian , Vogt Carolin , Horstkötter Theresa , Tippler Bettina , Xiao Han , Müller Bianca , Überla Klaus , Wagner Ralf , Asbach Benedikt , Bohne Jens
Published: May 2021

Alternative splicing and the expression of intron-containing mRNAs is one hallmark of HIV gene expression. To facilitate the otherwise hampered nuclear export of non-fully processed mRNAs, HIV encodes the Rev protein, which recognizes its intronic response element and fuels the HIV RNAs into the CRM-1-dependent nuclear protein export pathway. Both alternative splicing and Rev-dependency are regulated by the primary HIV RNA sequence. Here, we show that these processes are extremely sensitive to sequence alterations in the 5’coding region of the HIV genomic RNA. Increasing the GC content by insertion of either GFP or silent mutations activates a cryptic splice donor site in gag, entirely deregulates the viral splicing pattern, and lowers infectivity. Interestingly, an adaptation of the inserted GFP sequence toward an HIV-like nucleotide bias reversed these phenotypes completely. Of note, the adaptation yielded completely different primary sequences although encoding the same amino acids. Thus, the phenotypes solely depend on the nucleotide composition of the two GFP versions. This is a strong indication of an HIV-specific mRNP code in the 5′ gag region wherein the primary RNA sequence bias creates motifs for RNA-binding proteins and controls the fate of the HIV-RNA in terms of viral gene expression and infectivity.
Targeted Delivery of BZLF1 to DEC205 Drives EBV-Protective Immunity in a Spontaneous Model of EBV-Driven Lymphoproliferative Disease
Authors: Ahmed Elshafa Hassan , Brooks Eric , Sloan Shelby , Schlotter Sarah , Jeney Frankie , Hale Claire , Mao Charlene , Zhang Xiaoli , McLaughlin Eric , Shindiapina Polina , Shire Salma , Das Manjusri , Prouty Alexander , Lozanski Gerard , Mamuye Admasu T. , Abebe Tamrat , Alinari Lapo , Caligiuri Michael A. , Baiocchi Robert A.
Published: May 2021

Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world’s population and is linked to development of cancer. In immune-competent individuals, EBV infection is mitigated by a highly efficient virus-specific memory T-cell response. Risk of EBV-driven cancers increases with immune suppression (IS). EBV-seronegative recipients of solid organ transplants are at high risk of developing post-transplant lymphoproliferative disease (PTLD) due to iatrogenic IS. While reducing the level of IS may improve EBV-specific immunity and regression of PTLD, patients are at high risk for allograft rejection and need for immune-chemotherapy. Strategies to prevent PTLD in this vulnerable patient population represents an unmet need. We have previously shown that BZLF1-specific cytotoxic T-cell (CTL) expansion following reduced IS correlated with immune-mediated PTLD regression and improved patient survival. We have developed a vaccine to bolster EBV-specific immunity to the BZLF1 protein and show that co-culture of dendritic cells (DCs) loaded with a αDEC205-BZLF1 fusion protein with peripheral blood mononuclear cells (PMBCs) leads to expansion and increased cytotoxic activity of central-effector memory CTLs against EBV-transformed B-cells. Human–murine chimeric Hu-PBL-SCID mice were vaccinated with DCs loaded with αDEC205-BZLF1 or control to assess prevention of fatal human EBV lymphoproliferative disease. Despite a profoundly immunosuppressive environment, vaccination with αDEC205-BZLF1 stimulated clonal expansion of antigen-specific T-cells that produced abundant IFNγ and significantly prolonged survival. These results support preclinical and clinical development of vaccine approaches using BZLF1 as an immunogen to harness adaptive cellular responses and prevent PTLD in vulnerable patient populations.
2 °C vs. High Warming: Transitions to Flood-Generating Mechanisms across Canada
Authors: Teufel Bernardo , Sushama Laxmi
Published: May 2021

Fluvial flooding in Canada is often snowmelt-driven, thus occurs mostly in spring, and has caused billions of dollars in damage in the past decade alone. In a warmer climate, increasing rainfall and changing snowmelt rates could lead to significant shifts in flood-generating mechanisms. Here, projected changes to flood-generating mechanisms in terms of the relative contribution of snowmelt and rainfall are assessed across Canada, based on an ensemble of transient climate change simulations performed using a state-of-the-art regional climate model. Changes to flood-generating mechanisms are assessed for both a late 21st century, high warming (i.e., Representative Concentration Pathway 8.5) scenario, and in a 2 °C global warming context. Under 2 °C of global warming, the relative contribution of snowmelt and rainfall to streamflow peaks is projected to remain close to that of the current climate, despite slightly increased rainfall contribution. In contrast, a high warming scenario leads to widespread increases in rainfall contribution and the emergence of hotspots of change in currently snowmelt-dominated regions across Canada. In addition, several regions in southern Canada would be projected to become rainfall dominated. These contrasting projections highlight the importance of climate change mitigation, as remaining below the 2 °C global warming threshold can avoid large changes over most regions, implying a low likelihood that expensive flood adaptation measures would be necessary.
ACCIDENTE CEREBROVASCULAR Y FIBRILACIÓN AURICULAR EN UNA INSTITUCIÓN PRESTADORA DE SALUD DEL QUINDÍO
Authors: Tabares-Montoya Daniel Alberto , Barahona-Giraldo Stefany , Ramírez-Reyes Lucy , Nieto-Cárdenas Olga Alicia
Published: May 2021

Introducción: La Fibrilación Auricular (FA) se ha relacionado frecuentemente con el Accidente Cerebrovascular (ACV). Objetivo: Describir la prevalencia de FA y sus comorbilidades en pacientes de un programa de Riesgo Cardiovascular de una Institución Prestadora de Servicios de Salud (IPS) del Quindío. Material y método: Estudio descriptivo de corte transversal. Se accedió a las historias clínicas de 193 pacientes con diagnóstico de FA, con consentimiento institucional. Se obtuvo una muestra de 53 sujetos de estudio, calculada para población finita, ajustada por prevalencia, aleatorizada, con reemplazo sistemático, sino se tenía la información requerida. Se calculó prevalencia de FA y de Accidente Cerebrovascular isquémico (ACVi), el uso de medicamentos para control de frecuencia, control del ritmo y anticoagulantes, la escala CHA2-DS2-VASC y la clasificación del riesgo. Resultados: Se encontró prevalencia de FA del 5,01% y de ACVi del 7,55%. Índice de Masa Corporal (IMC) promedio de 27,44 (± 6,20). El carvedilol fue el medicamento más usado (50,94%) para control de la frecuencia, la amiodarona el medicamento más usado (11,32%) para control del ritmo y el rivaroxabán (50,94%) como anticoagulante. Se identificó hipertensión en 100% de los pacientes, diabetes en 37,74 % y enfermedad vascular en 32,98 %, las cuales son variables de la escala CHA2-DS2-VASC con alta prevalencia esta población. Conclusiones: La prevalencia de FA fue de 5,01% y la prevalencia de ACVi del 7,55%. El puntaje promedio de la escala CHA2-DS2-VASC fue 4,26 y el 88,68% de la población se encontró en riesgo alto de Accidente cerebrovascular.
Analisis Pendapatan Dan Efisiensi Usahatani Padi Varietas Ciherang (Studi Kasus pada Kelompok Tani Wargi Saluyu di Desa Ciparay, Kecamatan Ciparay, Kabupaten Bandung)
Authors: Haris Farid Abdul , Nataliningsih Nataliningsih , Permana Nendah Siti
Published: May 2021

This research was conducted to analyze the level of income and efficiency of rice farming in the Wargi Saluyu farmer group, Ciparay Village. The rice varieties that are the focus of this research are the Ciherang variety. The method used in this research is the case study method. With the concept of farming and farm acceptance and income. So this research uses income analysis and R / C ratio analysis (Return Ana Cost Ratio), namely the comparison analysis and farm acceptance. The data used in the study were obtained from direct interviews with farmers who are members of the Wargi Saluyu farmer group in Ciparay Village and added with other supporting data that can support from literature and literature studies. The results of this study indicate the Ciherang variety rice farming in Ciparay Village, Ciparay District, Bandung Regency has a total cost of IDR 17,379,500.00 per hectare and revenue of IDR 34,742,000.00 per hectare which generates an income of IDR 17,362,500.00 per hectare. in one growing season. And the R / C ratio of Ciherang variety rice farming in Ciparay Village, Ciparay District, Bandung Regency is 1.9, which means that ciherang variety of rice farming in Ciparay Village, Ciparay District, Bandung Regency is profitable or feasible to be cultivated
İSTANBUL İLİ 2017 YILI İÇME VE KULLANMA SULARININ DEĞERLENDİRİLMESİ
Authors: Güner Abdullah Emre , Önal Ayşe Emel
Published: May 2021

İstanbul, Türkiye nüfusunun yaklaşık beşte birini oluşturan 16 milyonluk bir şehirdir, bu nedenle kaliteli içme ve kullanma suyu sağlamak hayati önem taşımaktadır. Bu çalışmada İstanbul ilindeki 2017 yılı içme kullanma sularının analiz sonuçlarının değerlendirilmesi amaçlanmıştır. Araştırma retrospektif verilerin kullanıldığı tanımlayıcı bir çalışmadır. İstanbul ilinde 36 noktada bulunan şebekelerden belirlenen 748 izleme noktasından Kontrol İzlem ve Denetim İzlem numunesi, 548 izleme noktasından Bakiye Klor Ölçümü numunesi alınarak, bir tanesi Anadolu yakasında iki tanesi Avrupa yakasında olmak üzere İstanbul Halk Sağlığı 1-2-3 No’lu Referans Laboratuvarlarında (HSL) analizleri yapılmaktadır. Veriler SPSS 21.0 paket programı ile değerlendirilmiş, istatistiksel analizlerde yüzde, aritmetik ortalama, standart sapma kullanılarak yorumlanmıştır. İstatistiklerde %95 güven aralığı ve anlamlılık düzeyi p<0,05 olarak kabul edilmiştir. Araştırmada İstanbul ilindeki içme kullanma sularındaki ph değeri ortalaması 6,95±0,15 (min: 6,62-maks: 7,28); Koliform bakteri değeri ortalaması 17,09±99,47 (min:0,00-622,00) /100 ml; iletkenlik değeri ortalaması 376,22±78,52 (min: 282,06- maks:613,73) μS/cm; Escherichia coli miktarı ortalaması 3,13±18,98 (min:0,00-maks:118,60); demir miktarı ortalaması 34,38±18,81 (min: 6,79-maks: 103,70) μg/L olarak saptanmıştır. Araştırmada yapılan denetim izlem sonuçlarının %90,2’si, kontrol izlemlerinin %96,9’u ve bakiye klor ölçümlerinin %99,5’u uygun saptanmıştır. Ülkemizde su kalitesi izleme çalışmaları, çeşitli kurum ve kuruluşlar tarafından ulusal ve uluslararası sorumluluklar kapsamında yürütülmektedir. Çalışmalar birbirinden bağımsız olup, henüz entegre bir kirlilik izleme stratejisi uygulanmamaktadır. Bu konuda ortak paydaşlar ile çeşitli çalışmalar yapılmaktadır. Su kalitesi izleme çalışmalarını yürüten kurum ve kuruluşlar ile birbirine entegre ortak bir veri tabanı oluşturularak yapılan çalışmaların sonuçları paylaşıldığı takdirde zaman ve insan gücü kaybının da önüne geçilmiş olacaktır.
TÜM POLİTİKALARDA SAĞLIK YAKLAŞIMININ DEĞERLENDİRİLMESİ
Authors: Çakmak Barsbay Mehtap
Published: May 2021

İnsan sağlığı, büyük ölçüde sağlık sektörünün dışından gelen etkilere açıktır. Bu nedenle sağlık dışındaki aktörlerin, kamu politikaları geliştirme süreçlerine katkı ve katılımları önem taşımaktadır. Kamu sağlık politikaları geliştirme, ulusal kamu sağlık otoritelerinin çabalarının ötesinde kapsamlı ve bütüncül bir yaklaşım gerektirmektedir. Bu çalışmanın amacı, ‘Tüm Politikalarda Sağlık’ yaklaşımının önemini ve bu yaklaşımın, sağlık hizmetleri yönetimi için alternatif stratejik bir çerçeve olup olamayacağını irdelemektir. Bu bağlamda ‘Tüm Politikalarda Sağlık’ yaklaşımı tanımlanmış, kapasite geliştirme ve uzun dönemli hastalıklarla mücadelede kapasite geliştirme açısından tartışılmıştır.
The Dynamic of Teachers’ Job Performance
Authors: Virgana Virgana
Published: May 2021

Professional teacher performance is the hope of the Indonesian community to teach the next generation well. The research aimed to find out a direct and an indirect effect of exogenous variables toward endogenous variables. The sample research amounted to 360 public high school teachers in Jakarta. Smart-PLS with r > .70 is used to gain the validity and reliability test required to analyze research data. The results showed that there were: direct positive influences of organizational culture and personality on the trust and decision-making; the direct positive influence of organizational culture, trust, and decision-making on job performance; and also there was an indirect influence of organizational culture through trust on teachers’ job performance; an indirect influence of organizational culture through the decision-making on teachers' job performance; personality through trust on teachers’ job performance. Trust and decision-making as variables intervening did not have an effective influence on job performance, because pandemic has changed the situation of teacher performance.
Critical Review on Issues and Challenges of Malaysian Islamic financial system
Authors: Khan Issa , Muneem Abdul , Mansor Fadillah , Balwi Mohd Abd Wahab Fatoni Bin Mohd , Rahman Md. Mahfujur
Published: May 2021

This paper seeks to analyze the issues of the Islamic financial system and its challenges in Malaysia. This research adopts a qualitative approach based on data collected from articles, books, and online sources. A thematic approach has been utilized for data analysis. This study finds that Islamic banks impose both taʿwīḍ (compensation) and gharāmah (penalty) if the customer procrastinates or delays the payment of installments to the banks. That could lead to ribā (interest) in the contract. Therefore, the study suggests that the Islamic banks need to form a tabarruʿ (donation) fund. In addition, the study reveals that the Islamic banks are trending towards debt-based financing, which contradicts the maqāṣid al-sharīʿah. To fulfill the objective of the Sharīʿah, Islamic banks should apply more profit-sharing-based financing products. Another challenge in Islamic capital markets is baiʿ al-dayn (sale of debt) in Sukuk (Islamic bond), leading to ribā. Thus, the research proposes improving the transaction with a concept that does not lead to controversy. In family takaful, there are Sharīʿah issues related to the nominee and distribution of surplus. The study suggests that the nominee should work as an executor. Moreover, takaful companies can receive a portion of surplus based only on the muḍārabah model. Finally, this research identifies challenges in Islamic finance about human capital, misconceptions of Islamic finance, standardization, and harmonization, and proposes solutions accordingly. The research will assist the Islamic financial industry in finding ways to overcome the current issues and challenges.
Predictors of Organizational Commitment
Authors: Soeling Pantius Drahen , Aulia Muhammad Ichsan Iskandar , Indriati Fibria
Published: May 2021

Organizational commitment plays an essential role in the organization to create a competitive advantage for the organization. This study aims to examine the predictors of organizational commitment. Employee engagement, organizational learning, and work environment were used as predictors of organizational commitment. This study applied a quantitative approach with a questionnaire as a research instrument. The respondents were non-managerial permanent employees at one of the state-owned enterprises in Indonesia who had worked for at least one year in the company. The number sample of this study was 180 respondents. The data were analyzed using the Partial Least Square analysis technique. The results show that employee engagement and organizational learning affect employee organizational commitment positively and significantly. In addition, the work environment influences employee organizational commitment positively, but it is not significant. This study can help managers create effective planning that focuses on employee engagement and organizational learning to elevate organizational commitment.
Islamic Banking Service Innovation in Customer Co-Creation: Its Impact on Customer Trust, Satisfaction, and Loyalty
Authors: Asnawi Nur , Setyaningsih Nina Dwi
Published: May 2021

This study examines the impact of co-creation on customer trust, satisfaction, and loyalty in the context of Islamic banks, the relationship between co-creation and customer satisfaction and loyalty mediated by trust and customer satisfaction. 379 Islamic bank customers data were analyzed using variance-based structural equation modeling to test the nine hypotheses proposed. The study results found that customer co-creation positively influences customer trust and satisfaction, which further implicates loyalty. However, surprisingly co-creation does not affect Islamic bank customer loyalty. Islamic bank managers in Indonesia need to involve customers to participate in value co-creation. Because Islamic bank's customer loyalty relationship with co-creation is mediated in full by trust and satisfaction, this research is the first empirical investigation that tests customer co-creation in an integrated manner and its implications on trust, satisfaction, and customer loyalty in the Islamic bank industry.
ROLE OF OCTREOTIDE IN MANAGEMENT OF SULPHONYLUREA - INDUCED REFRACTORY HYPOGLYCEMIA : A CASE REPORT
Authors: Kothari Akshay , Shah Kiran
Published: May 2021

Hypoglycemia in diabetes is generally the result of interplay of relative or absolute therapeutic exogenous or endogenous insulin excess and
compromised physiological and behavioral defenses against falling blood glucose concentrations. Thus, it is fundamentally iatrogenic, the result of
treatments that include insulin or an insulin secretagogue such as glimepiride. The long-acting, synthetic somatostatin analog, octreotide, can be
used to correct refractory hypoglycemia caused by sulfonylurea. There have been few records of it being used in a clinical environment. We present
a case in which a subcutaneous injection of octreotide was successful in treating sulfonylurea-induced refractory hypoglycemia. The patient was
referred to our hospital for recurrent hypoglycemia caused by sulfonylurea. His medications included tablet glimepiride 4 mg once daily along with
tablet metformin 1000mg once daily. His plasma glucose level on arrival was 45 mg/dl. He was treated with 50 ml of 25% glucose solution and
administered continuous drip of 5% glucose solution through a peripheral vein, but his hypoglycemia recurred several times. Finally, 100 mcg of
octreotide was subcutaneously injected. Thereafter, hypoglycemia did not recur, and additional injections of glucose were not required. The
subcutaneous injection of octreotide can be an effective and safe method of treating prolonged, and refractory hypoglycemia caused by
sulfonylureas and alleviate impending complications, morbidity, and/ or mortality. The octreotide subcutaneous injection can be used as outpatient
department treatment and can greatly reduce the cost of hospitalization.
The SELFIE 2.0 project (SELF assessment for the therapeutic appropriateness in people with diabetes): proposals to impro­vethe approach to therapeutic intensification in patients with type 2 diabetes with inadequate metabolic control
Authors: Rossi, M.C.
Published: May 2021

The SELFIE project (SELF assessment for therapeutic appropriateness in people with diabetes) was designed to collect the perceptions and opinions of 60 diabetologists in 12 territorial meetings. The objective was to launch the debate between experts through a structured discussion procedure to identify the main “barriers to intensification” of diabetes treatment (first phase) and the “possible solutions” (second phase). The discussion took into account that DPP4-inhibitors prescription still requires a “therapeutic schedule” in Italy. So, the specific barriers of 8 different profiles (phenotypes) of patients with inadequate metabolic control, classified in terms of age, renal function and treatment with one or more glucose-lowering drugs were highlighted. This article summarizes the results of the second phase. Optimizing / simplifying drug therapy, establishing a therapeutic alliance with the patient, involving a caregiver to act on motivation / communication with the patient, improving organizational aspects, reducing bureaucracy and stimulating the doctor’s attitude to change are the key points that emerged as crucial for overcoming clinical inertia. Implementation of these solutions based on their applicability to the different phenotypes was debated though standardized discussion procedures. Implementing these solutions, monitoring their adoption and measuring the results obtained in the short- and long term, simultaneously focusing on the training of patients and healthcare professionals, is a challenge for the entire diabetes community, to improve the care provided and the clinical outcomes. KEY WORDS type 2 diabetes; glycemic targets; therapeutic inertia; DPP-IV inhibitors; professional education.
A tax for health: international experiences
Authors: Adinolfi, V.
Published: May 2021

Obesity, type 2 diabetes and their complications are consistently increasing all around the world, both in developed and in developing countries. Sweetened beverages consumption is considered an important contributor to the widespread of these diseases. This led many countries worldwide to create a “sugar tax”, a levy on sugar content of these beverages, to discourage the consumption of such drinks. This article will examine some of the most significant examples of sugar taxes worldwide and their current and potential impact on drinks sales and consumption and on incidence and prevalence of consequent metabolic diseases. “sugar tax”, “obesity, “type 2 diabetes”, “sweetened beverages”. KEY WORDS obesity; sugar tax; type 2 diabetes; sweetened beverages.
Telemedicine and digital narrative medicine for the customization of the diagnostic-therapeutic path at the time of COVID 19
Authors: Agrusta, M.
Published: May 2021

The Covid-19 issues have placed the telemedicine into the limelight, for its ability to reach remote patients affected by COVID-19, offering them support, expert advice, home hospitalization. At the same time, it gives the many fragile patients, who should be submitted to therapeutic checks or adjustments, the opportunity to be followed appropriately, avoiding travelling and associated risks of contagion. The current situation has accelerated its use in diabetological care: but with the risk of reducing the medical-patient empathic relationship. Narrative Medicine (NBM) integrates with Evidence-Based Medicine (EBM) and, taking into account the plurality of perspectives, makes clinical-care decisions more complete, personalized, effective and appropriate. The stories told by patient and by those who take care, are an essential element of contemporary medicine, based on the active participation of the subjects who are involved in the choices. People, through their own stories, become protagonists of the process of care”. The ability of mixing the technology achievements with the humanistic vision of the care process characterizes DNM, the first digital platformentirely designed for the development of narrative medicine projects in the clinical practice. It was conceived by a team of anthropologists and psychologists with the advice of doctors and experts in narrative medicine of OMNI the Observatory of Narrative Medicine Italy. The DNM features aim to maximize the potential of the digital process, at the same time preserving patient privacy and health data confidentiality. KEY WORDS telemedicine; narrative medicine; digital narrative medicine.
Проєкт благоустрою та озеленення внутрішньо-квартальної території у місті Запоріжжя
Authors: Дерев'янко Н. П.
Published: May 2021

Важливим заходом, що дає змогу надати старій прибудинковій території привабливого естетичного та екологічного стану, є її озеленення. Зокрема, новий благоустрій двору багатоквартирного будинку є важливим з погляду зручності розташування необхідних об'єктів інфраструктури, які не враховувались під час будівництва будинку. Для цього може знадобитися робота над рельєфом і ландшафтом та зведення малих архітектурних споруд. Територія розташована за адресою вул. Гудименко, 22 (вул. Героїв 93-ї бригади), міста Запоріжжя та потребує певних змін як з погляду будівельних робіт, так і з ландшафтного дизайну. Ділянка розташована у Хортицькому районі у формі прямокутника. Площа об'єкта – 13125 м2. З усіх боків оточена житловими дев'ятиповерховими будинками та обмежена проїзною дорогою. Упродовж дня ділянка добре освітлюється, але світла від ліхтарів недостатньо у темну пору доби. Ця територія досить людна як рано, так і ввечері, тому що поряд розміщені школа та дитячий садок. Розроблений проєкт благоустрою та озеленення внутрішньо-квартальної території значно покращить вигляд цього об'єкта. За допомогою інвентаризації встановлено такі показники, як: баланс території, видовий та породний склад дерев і чагарників, їх кількість, стан і особливості, стан газону. Відповідно зміна зовнішнього вигляду об'єкта озеленення зробить його набагато зручнішим у користуванні. Заплановано висадити декілька композицій, в асортимент яких будуть входити хвойні дерева та чагарники, вічнозеленi, листопаднi кущi, багаторiчнi та ґрунтопокривні рослини. Запроєктовано невеликий живопліт з вічнозелених багаторічних кущів, посаджених у формі незавершеного прямокутника, на території, яка оточує торгівельний МАФ.
Прогнозування дефектів у програмному забезпеченні алгоритмами глибинного навчання CNN та RNN
Authors: Білецький Т. П. , Федасюк Д. В.
Published: May 2021

Досліджено процес прогнозування дефектів у програмному забезпеченні (ПЗ) з використанням алгоритмів глибинного навчання. Показано, що цей процес складається з декількох основних етапів: пошук та підготовка даних, побудова абстрактного синтаксичного дерева (АСД), обхід дерева та кодування значень вершин у цілі числа, збалансування даних, побудова та навчання нейронної мережі. З'ясовано, що застосування цього процесу прогнозування дефектів у ПЗ може пришвидшити та полегшити пошук дефектів та відповідно знизити вартість їх виправлення. Встановлено, що передові алгоритми машинного навчання, які на цей момент використовуються на етапі побудови та навчання нейронної мережі, досі є недостатньо ефективними, щоб можна було застосовувати прогнозування дефектів у комерції, демонструючи нестабільну точність 40-60 %. За результатами досліджень встановлено, що застосування алгоритмів глибинного навчання дає точніші результати, ніж інші алгоритми машинного навчання. Для зниження дисперсії та підвищення середньої точності прогнозування запропоновано новий метод прогнозування дефектів у ПЗ на підставі поєднання двох останніх модифікацій алгоритмів глибинного навчання CNN та RNN за допомогою бінарного класифікатора логістична регресія. Проведено навчання нейронної мережі на наборі даних розміром 50 000 файлів вихідного коду, отриманих з 13-ти проєктів мовою Java. За результатами досліджень виявлено, що метод CNN+RNN в середньому дає на 10-9 % вищу точність, ніж RNN та на 2 % вищу точність, ніж CNN, що доводить доцільність використання поєднання алгоритмів глибинного навчання у задачі прогнозування дефектів. Проаналізовано точність методу CNN+RNN по кожному з ПЗ проектів з набору даних, унаслідок чого виявлено, що для 11-ти з 13-ти проєктів поєднання CNN+RNN дає не меншу точність, ніж окремо взяті CNN та RNN.
Edukasi Pemanfaatan Bahan Pangan Lokal sebagai Booster ASI
Authors: Aswita Aswita , Nurmiaty Nurmiaty , Wulandari Hesti
Published: May 2021

Potensi penggunaan pangan lokal seperti daun kelor, daun katuk, pepaya muda, dan jantung pisang dapat dimanfaatkan sebagai booster ASI oleh ibu menyusui. Edukasi tentang pemanfaatan bahan makanan lokal sebagai booster ASI diperlukan agar para ibu menyusui dan keluarga dapat mengaplikasikan pengetahuan yang diperoleh untuk meningkatkan produksi ASI. Tujuan kegiatan pengabdian kepada masyarakat ini untuk meningkatkan pengetahuan ibu menyusui dan keluarga tentang pemanfaatan bahan pangan lokal sebagai booster ASI. Metode yang digunakan yaitu ceramah tanya jawab dengan memberikan modul. Lokasi pengabdian kepada masyarakat dilaksanakan di Desa Telaga Biru Kecamatan Soropia Kabupaten Konawe Sulawesi Tenggara. Hasil pre-postest menunjukkan adanya peningkatan pengetahuan peserta dari rerata skor pengetahuan 68,5 menjadi 89 setelah diberikan edukasi. Melalui pengabdian kepada masyarakat ini diharapkan ibu dapat memaksimalkan konsumsi bahan pangan lokal yang dapat meningkatkan produksi ASI sehingga ibu berhasil menyusui.
Double sequence spaces defined by a sequence of modulus functions
Authors:   SCHOOL OF MATHEMATICS SHRI MATA VAISHNO DEVI UNIVERSITY KATRA-182320, J&K, INDIA. E-mail address: kuldeepraj68@rediffmail.com, RAJ KULDIP , SHARMA SUNIL K. ,   SCHOOL OF MATHEMATICS SHRI MATA VAISHNO DEVI UNIVERSITY KATRA-182320, J&K, INDIA. E-mail address: sunilksharma42@yahoo.co.in
Published: May 2021

In the present paper we introduce double sequence spaces defined by a sequence of modulus functions F = (fk,l). We also make an effort to study some topological properties and inclusion relations between these spaces.
On farthest and simultaneous farthest points in Kothe spaces
Authors:   DEPARTMENT OF MATHEMATICS YARMOUK UNIVERSITY IRBID, JORDAN E-mail address: sharifa@yu.edu.jo, AL-SHARIF SH.
Published: May 2021

Let X be a real Banach space and G be a closed bounded subset of X. For x e X, we set ρ (x, G) = sup {kx − yk : y e G} . The set G is called remotal if for any x e X, there exists g e G such that ρ (x, G) = kx − gk . In this paper we show that for a separable remotal set G ⊂ X, the set E(G) is remotal in E(X), where E(X) is the Kothe Bochner function space. Some other results are presented.