bluuebunny/crossref_metadata_2025 huggingface dataset:
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities
Authors: Adnan Muhammad , Rasul Azhar , Hussain Ghulam , Shah Muhammad Ajmal , Sarfraz Iqra , Nageen Bushra , Riaz Ammara , Khalid Rida , Asrar Muhammad , Selamoglu Zeliha , Adem Şevki , Sarker Satyajit D.
Published: October 2020

Nature has provided prodigious reservoirs of pharmacologically active compounds for
drug development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are bioactive
natural anthraquinones which exert anti-inflammatory and anticancer properties with minimum
or no adverse effects. Moreover, physcion also exhibits anti-microbial and hepatoprotective properties,
while PG is known to have anti-sepsis as well as ameliorative activities against dementia. This
review aims to highlight the natural sources and anticancer activities of physcion and PG, along
with associated mechanisms of actions. On the basis of the literature, physcion and PG regulate
multitudinous cell signaling pathways through the modulation of various regulators of cell cycle,
protein kinases, microRNAs, transcriptional factors, and apoptosis linked proteins resulting in the
effective killing of cancerous cells in vitro as well as in vivo. Both compounds effectively suppress
metastasis, furthermore, physcion acts as an inhibitor of 6PGD and also plays an important role in
chemosensitization. This review article suggests that physcion and PG are potent anticancer drug
candidates, but further investigations on their mechanism of action and pre-clinical trials are mandatory
in order to comprehend the full potential of these natural cancer killers in anticancer remedies.
Natriuretic Peptides as the Basis of Peptide Drug Discovery for Cardiovascular Diseases
Authors: Lerner Yana , Hanout Wessal , Ben-Uliel Shulamit Fluss , Gani Samar , Leshem Michal Pellach , Qvit Nir
Published: October 2020

Cardiovascular diseases (CVDs) are the leading global cause of death, accounting for more
than 17.6 million deaths per year in 2016, a number that is expected to grow to more than 23.6 million
by 2030. While many technologies are currently under investigation to improve the therapeutic outcome
of CVD complications, only a few medications have been approved. Therefore, new approaches
to treat CVD are urgently required. Peptides regulate numerous physiological processes, mainly by
binding to specific receptors and inducing a series of signals, neurotransmissions or the release of
growth factors. Importantly, peptides have also been shown to play an important role in the circulatory
system both in physiological and pathological conditions. Peptides, such as angiotensin II, endothelin,
urotensin-II, urocortins, adrenomedullin and natriuretic peptides have been implicated in the control of
vascular tone and blood pressure as well as in CVDs such as congestive heart failure, atherosclerosis,
coronary artery disease, and pulmonary and systemic hypertension. Hence it is not surprising that peptides
are becoming important therapeutic leads in CVDs. This article will review the current knowledge
on peptides and their role in the circulatory system, focusing on the physiological roles of natriuretic
peptides in the cardiovascular system and their implications in CVDs.
COVID-19 and Type 2 Diabetes Mellitus: HCQ may be the Holy Grail
Authors: Pal Rimesh , Bhasin Manoj K. , Bhadada Sanjay K.
Published: October 2020

The novel coronavirus disease (COVID-19) is on the rampage claiming over 297000
lives globally. Disease severity and mortality rates are higher in patients with underlying diabetes
mellitus. Till date, there exists no effective vaccine or therapy against COVID-19. However, with
limited clinical data, HCQ is being used for treatment and prophylaxis in patients with COVID-19.
HCQ is also used as an anti-diabetic drug and has been approved in India as an adjunct to diet and
exercise to improve glycemic control of patients with Type 2 Diabetes Mellitus (T2DM) on metformin
and sulfonylurea combination in Type 2 Diabetes Mellitus (T2DM). Thus, although indiscriminate
use of HCQ is fraught with danger, HCQ can be considered as a third-line add on anti-diabetic
agent in people with T2DM amid the ongoing pandemic after having ruled out the contraindications
to the use of this drug.
Comprehensive Study on Sliding Surface and Stability of a Soil Landslide
Authors: Fayou A. , Dai Xuegang , Yan Shiqan , Liao Chenxi
Published: October 2020

Objective:

The paper aims to solve the problem of determining the sliding surface of soil landslide,
and to provide the basis for landslide stability analysis and prevention engineering.

Methods:

In this paper, the sliding surface is determined by field exploration, and the sliding surface is
comprehensively determined by FLAC3D numerical simulation method. At the same time, Sweden Arc
Method and FLAC3D numerical simulation are used to make a comprehensive comparative analysis on the
deformation and stability of the landslide.

Results:

The position of the sliding surface of dawanjiang landslide is determined by FLAC3D numerical
simulation method, which is located in the eluvium and the maximum depth is about 7m, which is basically
consistent with the speculated position. It provides a theoretical basis for landslide stability calculation and
control engineering.

Conclusions:

In the determination of sliding surface and stability calculation of soil landslide, the
comprehensive analysis combined with numerical simulation is the more reliable method.
Effect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes
Authors: Chen Qi , Wang Zi , Zhou Jingwei , Chen Zhenjie , Li Yan , Li Shichao , Zhao Hukang , Badve Sunil V. , Lv Jicheng
Published: October 2020

Background and objectives

Several clinical practice guidelines noted the potential benefits of urate-lowering therapy on cardiovascular disease and CKD progression; however, the effect of this regimen remains uncertain. In this systematic review, we aimed to evaluate the efficacy of urate-lowering therapy on major adverse cardiovascular events, all-cause mortality, kidney failure events, BP, and GFR.

Design, setting, participants, & measurements

We systematically searched MEDLINE, Embase, and the Cochrane databases for trials published through July 2020. We included prospective, randomized, controlled trials assessing the effects of urate-lowering therapy for at least 6 months on cardiovascular or kidney outcomes. Relevant information was extracted into a spreadsheet by two authors independently. Treatment effects were summarized using random effects meta-analysis.

Results

We identified 28 trials including a total of 6458 participants with 506 major adverse cardiovascular events and 266 kidney failure events. Overall urate-lowering therapy did not show benefits on major adverse cardiovascular events (risk ratio, 0.93; 95% confidence interval, 0.74 to 1.18) and all-cause mortality (risk ratio, 1.04; 95% confidence interval, 0.78 to 1.39) or kidney failure (risk ratio, 0.97; 95% confidence interval, 0.61 to 1.54). Nevertheless, urate-lowering therapy attenuated the decline in the slope of GFR (weighted mean difference, 1.18 ml/min per 1.73 m2 per year; 95% confidence interval, 0.44 to 1.91) and lowered the mean BP (systolic BP: weighted mean difference, −3.45 mm Hg; 95% confidence interval, −6.10 to −0.80; diastolic BP: weighted mean difference, −2.02 mm Hg; 95% confidence interval, −3.25 to −0.78). There was no significant difference (risk ratio, 1.01; 95% confidence interval, 0.94 to 1.08) in the risk of adverse events between the participants receiving urate-lowering therapy and the control group.

Conclusions

Urate-lowering therapy did not produce benefits on the clinical outcomes, including major adverse cardiovascular events, all-cause mortality, and kidney failure. Thus, there is insufficient evidence to support urate lowering in patients to improve kidney and cardiovascular outcomes.
SERUM LIPID AND TRACE MINERAL PROFILES AMONG TYPE 2 DIABETICS AND HYPERTENSIVE DIABETICS AT THE BAMENDA REGIONAL HOSPITAL
Authors: LUKONG HUBERT SHALANYUY  , SAMJE MOSES
Published: October 2020

Objective: Diabetes mellitus has become a clinical condition of public health importance, especially in developing countries due to its high mortality and morbidity. The aim of this study was to measure and compare the lipid and serum trace mineral profile among type 2 diabetics and hypertensive diabetics with controls.

Methods: This cross-sectional study was carried out at the Regional Hospital, Bamenda, involving 50 diabetic normotensives, 50 hypertensive diabetics, and 50 normal recruited subjects. Serum levels of lipids and minerals were determined using standard methods.

Results: Of the four trace elements assessed, except for copper (Cu) whose mean values in diabetics were abnormally increased (p=0.01), zinc (Zn), magnesium (Mg), and chromium (Cr) showed significantly decreased mean values in diabetics compared to the controls (p<0.05). The mean levels of these trace elements were also significantly reduced in hypertensive diabetic patients (p<0.05). In diabetics, there was no significant difference in the lipid levels. However, only total cholesterol (TC) and low-density lipoprotein mean values were significantly higher in hypertensive diabetic patients compared to the normal controls. There was also a positive significant correlation between the body mass index and Cr (r=+0.3, p=0.045) in diabetics.

Conclusion: This study saw statistically significant differences in the serum lipid and trace element levels between diabetics, hypertensive diabetics, and controls: With diabetic and diabetic hypertensive patients having higher serum Cu levels and decreased serum Mg, Zn, and Cr levels compared to the normal controls. The lipid profile levels in diabetics and hypertensive diabetics were not significant differences within the study groups for all lipid profile estimations except for TC and LDL which were significantly higher only in hypertensive diabetic patients.
PROTECTIVE EFFECT OF PHYLLANTHUS EMBLICA EXTRACT PREVENT CONTRAST-INDUCED ACUTE KIDNEY INJURY IN RATS
Authors: SUPRANEE KONGKHAM  , ADIS TASANARONG  , ARUNPORN ITHARAT
Published: October 2020

Objective: The objective of the study was to investigate the anti-apoptosis effect of the extract from Phyllanthus emblica (PE) for the prevention of contrast-induced acute kidney injury (CI-AKI).

Methods: Male Sprague Dawley rats were given saline (control) or PE extracts (500 mg/kg/day) for 5 days before the induction of CI-AKI. Renal tissues were collected for an evaluation of gene expression and immunohistochemistry (IHC). To indicate anti-apoptotic effect, the expression levels of Bax, Bcl-2, and caspase in kidney were also determined, using real-time polymerase chain reaction (RT-PCR) and Western blot analysis.

Results: In the CI-AKI group, RT-PCR and Western blot analysis revealed that the expression levels of Bax and cleaved-caspase-3 were upregulated in the CI-AKI group, whereas the expression of Bcl-2 was downregulated. However, the pre-treatment with PE increased Bcl-2 expression. Moreover, decreased cleaved-caspases-3 activity was also detected using IHC.

Conclusion: These findings suggested that pretreatment with PE extract provided the anti-apoptotic effect against CI-AKI in the rat model.
EFFECTIVENESS OF INITIAL SOLUTIONS INCORPORATED INTO EARLY INTERVENTION DELIVERY SYSTEMS FOR CHILDREN WITH HEARING LOSS: EVIDENCE FROM HAI PHONG, VIETNAM
Authors: XUONG TUYET NGUYEN  , HA NGOC NGUYEN  , TRAM VAN TA  , VU KIEN TRAN  , HIEN THE PHAM
Published: October 2020

Objective: Hearing loss is a serious disease that needs attention from society because of its considerable effects on the normal development of children. This study incorporated systematic solutions into early intervention delivery systems for children with hearing loss in Hai Phong, Vietnam, and evaluated the effectiveness of the strategies.

Methods: This community intervention study, which was carried out from 2013 to 2014, involved a comparison of the early intervention delivery systems before and after the implementation of the proposed solutions.

Results: Two years after the solutions were applied, the following results were derived: The availability of resources and the quality of service provision improved and access to and the use of services by families whose children suffer from hearing loss increased. The solutions also facilitated the creation of an early communal intervention program and significantly enhanced the situations of children with hearing loss as regards the average ages at which disease onset was suspected, the disease was definitively identified, hearing aid fitting was initiated, and language intervention was implemented (15.5, 21, 23.7, and 26.5 months, respectively). Finally, the solutions enabled detection, diagnosis, and early intervention at <12 and 24 months of age (p<0.001).

Conclusion: The strategy of reinforcing intervention programs with general and comprehensive solutions can be expanded to other Vietnamese provinces grappling with similar problems.
Impacto de la influencia de la familia en el negocio, sobre el proceso de gestión financiera y la generación del valor en el sector textilconfección en la Ciudad de Medellín y su Área Metropolitana, Colombia
Authors: Molina Parra Paula Andrea , Montoya Restrepo Iván Alonso , Botero Botero Sergio
Published: October 2020

El propósito de esta investigación es medir el impacto de la incidencia de la familia sobre el proceso de gestión financiera y la generación de valor en las empresas del sector textil-confección en la Ciudad de Medellín y su área metropolitana. La primera relación se midió a través de un método avanzado de estadística multivariada, la correlación canónica y la segunda con una regresión múltiple, en una muestra probabilística de 100 empresas. Se encontró que la incidencia de la familia impacta positivamente la planeación financiera, el control financiero, las decisiones de inversión, la gestión del capital de trabajo y las decisiones de financiamiento; el impacto causado sobre el EVA es positivo pero débil.
Dinámica de la cadena global aeroespacial: un análisis de teoría de grafos
Authors: Díaz Rodríguez Héctor Eduardo , Morales Sánchez Mario Alberto , Sandoval Cabrera Seyka
Published: October 2020

Este estudio analiza mediante teoría de grafos y con la metodología de cadenas globales de valor, los cambios ocurridos en el comercio aeroespacial global en el último cuarto de siglo. Se identifican patrones de comercio en los que los países líderes, si bien descentralizan una parte de la producción, dichos cambios no alteran sus condiciones de liderazgo. Países como Canadá y China, que no se han integrado a la cadena global de valor de la industria en forma tradicional, se han convertido líderes, mientras que países como México que se han integrado en la cadena siguiendo la teoría del upgrading tecnológico, se han quedado rezagados a la producción de los segmentos más bajos de valor de la cadena.
Competitividad estructural de las exportaciones del sector textil mexicano: un análisis comparativo con respecto a sus competidores
Authors: Vázquez López Raúl
Published: October 2020

Desde una perspectiva estructural, el presente artículo analiza la evolución de las exportaciones de la industria textil mexicana, en términos de la composición de los productos vendidos en los mercados de los Estados Unidos (E.U.) y la Unión Europea (U.E.), de 1994 a 2015, comparando su desempeño con respecto al de sus principales competidores en cada caso (Canadá, China e India en el mercado de los E.U. y China, India y Turquía en el mercado de la U.E.). La aplicación de una técnica estadística de tipo diferencial-estructural (shift-share) revela la inexistencia de un cambio estructural cualitativo relevante, que permitiera generar capacidades tendientes a desarrollar ventajas competitivas sustantivas en productos alternativos de mayor valor agregado al amparo del TLCAN. Comparativamente, en el caso chino, el perfil competitivo fue diversificándose en dirección de productos más sofisticados en una senda planificada de escalamiento productivo. En cuanto a las exportaciones mexicanas al mercado europeo, los hallazgos obtenidos muestran indicios de una transformación regresiva, en la que las ventas de prendas de vestir, originalmente destinadas a E.U., fueron redireccionadas hacia la U.E, en detrimento de la profundización de las exportaciones de insumos elaborados de mayor valor agregado.
Construction of the fate of engineer M.F. Balgi
Authors: Prilukova Ekaterina G. , Chuprin Vadim V.
Published: October 2020

There are people and events that have gone down in history and are known in the world. One of them is the designer of combat vehicles M. F. Balzhi, without which the history of the creation of the IS-3 tank will cease to be. (Research purpose) The research purpose is to show the development of an engineer-designer of technology M. F. Balzhi. (Materials and methods) The methodological framework of the study is set by the requirements of the methodological hermeneutical standard, the cognitive model of "the dual nature of man as a thinking being and a feeling being" by P. Sorokin, methodological guidelines of "history of concepts" and "oral history". The research material is the representation of M. F. Balzhi's creativity by colleagues and students in "reified" memory. (Results and discussion) A biography of Michael Bali is typical for his contemporaries. The article notes that although country events have a significant impact on the formation of a person, much depends on the character of the person, its inner core. The article shows that M. Bali was fond of mechanics and tried to gain new knowledge. In November 1935, he began working at the Chelyabinsk tractor plant, where work was underway to create a new S-65 tractor. The second half of the 30s was noted by the creation of Soviet tanks and marked the beginning of the "tank period" in the life of M. Balzhi, who proposed the basis for new tank designs. After the Second World War, M. F. Balzhi designed the S-65 and S-80 tractors, developed and introduced the ATS-2 artillery tractor and the IS-4 heavy tank into mass production. Since 1949, the design engineer began teaching, for 20 years he headed the Tanks Department. M. F. Balzhi has published more than 150 scientific papers and has trained 13 postgraduates. (Conclusions) In our country, there is a huge gap between unique design ideas and solutions born in the bowels of design bureaus and their practical implementation. It is worth referring to the experience of organizing the work of the design engineer M. F. Balzhi, whose inquisitive mind sought not only to obtain knowledge and create new things, but also to find practical applications for them.
Ensuring quality and accuracy characteristics when restoring vehicle parts
Authors: Zhachkin Sergey Yu. , Pen’kov Nikita A. , Krasnova Marina N. , Plakhotin Aleksandr A. , Zadorozhnyy Roman N.
Published: October 2020

Electroplating chromium-containing coatings on the surface of the parts to be restored is an effective way to increase their wear resistance and corrosion protection. The price of equipment used in various industries and having hydraulic or pneumatic actuators of the working parts, as well as the cost of maintaining it in working condition during operation, are largely determined by the ability to get the thickness in the process of restoring the coating with the specifi ed project and preserving the confi guration of the original part without the use of mechanical processing of galvanic coating. (Research purpose) The research purpose is to determine the features of changes in the performance characteristics of the deposited coating depending on changes in the parameters of electrolysis and mechanical action on the restored part. (Materials and methods) Authors carried out tests on experimental sleeves made of 30 HGSA steel on TU 14-1-950-74, to determine the performance parameters of machining parts by galvanocontact deposition. The research on algorithms calculated using the theory of experiment planning has been performed. (Results and discussion) The article presents the dependence of some operational parameters (microhardness of the coating and residual stresses in it) on various control factors (current density, temperature, tool pressure). The complete factorial experiment was of 24 plan. The regression equations of individual parameters characterizing the quality of the created coatings were determined using the experiment planning theory. It was noted that one of the non-stationary methods of electrolysis was used to obtain this type of precipitation; it is the coating with simultaneous 95 mechanical treatment in a galvanic bath during deposition. It was revealed that these coatings have compressive residual stresses, increased adhesion to the base, minimal thickness difference. (Conclusions) The studies provide an opportunity to predict the quality of the resulting coatings in the restoration of vehicle parts.
Effect of N-acetyl-L-cysteine (NAC) on soluble sugar and polyamine content in wheat seedlings exposed to heavy metal stress (Cd, Hg and Pb)
Authors: Colak Nesrin , Tarkowski Petr , Ayaz Faik
Published: October 2020

Heavy metal stress adversely affects plant growth and productivity worldwide.
Alleviating the stress effect through the exogenous use of various chemical
substances has become an interesting area of study in the field of plant
stress tolerance. As a thiol compound, the cysteine derivative
N-acetylcysteine (N-acetyl- L-cysteine, NAC) is the precursor of glutathione
synthesis and a potent ROS scavenger with powerful antioxidant and free
radical scavenging capabilities. This study investigated the effects of
heavy metals (Cd, Hg and Pb, 100 ?M) on accumulation of soluble sugars and
polyamine content in roots and shoots of wheat seedlings, the water
potential and proline content in shoots and the role of NAC in protection
against heavy metal toxicity. The addition of 1 mM NAC significantly
increased root content of glucose, fructose and sucrose in varying degrees
(avg. 1.34-, 1.20- and 1.51-fold, respectively) in comparison with heavy
metals alone. The treatments led to a significant reduction of sugar content
in shoots. Water potential values were highly correlated with proline and
sugar content in wheat seedling shoots. Heavy metal stress significantly
reduced polyamine content in both plant parts. The addition of NAC increased
polyamine content in seedlings in comparison with heavy metals alone in both
roots and shoots. These results suggest that NAC may protect plants from
oxidative stress damage in heavy metal stress, and this enhancement of
stress tolerance seems to involve soluble sugar and polyamine biosynthesis.
COVID19 impact on women on both sides of the frontline: The American College of Cardiology Women in Cardiology Section’s International Working Group perspective
Authors: Parapid Biljana , Alasnag Manal , Hayes Sharonne , Samargandy Sondos , Banerjee Shrilla , Alasnag Mirvat , Singh Toniya , ACC WIC
Published: October 2020

At the beginning of the SARS Co V2 (COVID-19) pandemic, women worldwide represented the majority of health care workers. As part of the fight against the pandemic, women health care workers became a part of the significant frontline response. This led to unique challenges that affected women physicians as well as the women patients they were taking care of. The American College of Cardiology Women in Cardiology International Working Group set up a webinar to discuss the challenges being faced by women physicians and women patients in various parts of the world and look towards finding possible solutions for these issues in a webinar themed ?WIC Global Perspectives: COVID-19.?
The Spillover Effect of Consolidating Securitization Entities on Small Business Lending
Authors: Dou Yiwei
Published: October 2020

I investigate how the consolidation of securitization entities under SFAS 166 and 167 spills over to banks' supply of small business loans, which are rarely securitized in the United States. This spillover operates through two channels. (1) In the leverage channel, consolidating banks downsize their entire loan portfolios, both small business loans and other loans, in response to increased leverage after consolidation. (2) In the risk management channel, consolidating banks adjust the mix of loans to maintain optimal diversification. The adjustment can increase the supply of small business loans when their performance covaries positively with the performance of other loans. I find that, on average, banks that consolidate more securitized assets reduce small business lending; consequently, counties with a greater market share of consolidating banks experience slower growth in small businesses. I also identify a small group of banks with sufficiently large positive performance covariance that increase small business lending.

Data Availability: All untabulated results are available upon request.

JEL Classifications: M4; G21.
The Importance of IRS Enforcement to Stock Price Crash Risk: The Role of CEO Power and Incentives
Authors: Bauer Andrew M. , Fang Xiaohua , Pittman Jeffrey A.
Published: October 2020

We analyze whether tough IRS monitoring generates a positive externality by constraining managers' bad news hoarding activities. Supporting this prediction, we find a negative relation between the threat of an IRS audit and stock price crash risk. Our evidence is consistent with recent theory that outside investors learn more about firms when tax enforcement is stricter. Additionally, path analysis suggests that the monitoring channel (direct path) plays a critical role in shaping crash risk relative to information asymmetry channels of tax planning and accruals manipulation (indirect paths). Consistent with other predictions, we find that the monitoring role of IRS audits intensifies when firms experience worse agency conflicts stemming from CEO power and incentives. Collectively, our research implies that external monitoring by tax authorities protects shareholders against managers suppressing negative firm-specific information that engenders stock price crash risk, particularly when CEOs have wider scope and stronger incentives to hoard bad news.
Avaliação de desempenho dos Institutos Federais: um estudo de caso na terceira expansão da Rede Federal de Educação Profissional em Pernambuco
Authors: Barbosa  Lopes Alba De Oliveira , Araújo Richard Medeiros de
Published: October 2020

Resumo: Este trabalho teve como objetivo avaliar o desempenho dos Institutos Federais pernambucanos pertencentes à terceira expansão da Rede Federal de Educação Profissional, Científica e Tecnológica, em Pernambuco. O procedimento metodológico está fundamentado numa abordagem quantitativa, aplicada e descritiva. Os dados foram coletados através da base de dados Plataforma Nilo Peçanha, lançada em 2018, com anos-bases 2017 e 2018. Foram importantes também documentos do Tribunal de Contas da União (TCU) relativos à atuação da referida rede, bem como o Plano Nacional da Educação (Lei nº. 13.005/2014). Foram 9 unidades e 26 cursos investigados por meio de indicadores constantes no Acórdão nº 2.267/2005 do TCU nos seguintes indicadores: inscritos por vaga, eficiência acadêmica, evasão do ciclo, retenção do ciclo, matrícula por professor e titulação do corpo docente. Por descontinuidade dos dados nos anos em questão, 3 campi e 14 cursos foram excluídos da análise comparativa. Dos 12 cursos restantes, com dados completos, observou-se que: a) apenas o curso de Logística supera a média da rede federal de inscritos por vaga, em 2017 e 2018; b) somente dois cursos (Logística e Qualidade) atingiram a média da eficiência acadêmica da rede nos dois anos; c) não mais que três cursos (Logística, Qualidade e Administração) estão com taxas de evasão no ciclo menores do que a média da rede; d) três cursos estão com taxas de retenção no ciclo menores do que a média da rede, são eles: Informática para Internet, campus Jaboatão e Qualidade e Administração. Quando analisados indicadores dos campi e não dos cursos, obteve-se que: a) a relação matrícula por professor, regular em 2017 na maioria dos campi, extrapolou, no ano seguinte, a meta estabelecida pelo Plano Nacional de Educação (2014-2024) e b) o índice de titulação do corpo docente, mostrou-se inadequado em relação à meta estabelecida na lei, para apenas dois campi – Igarassu e Palmares. Esse trabalho ressalta que a busca pela melhoria dos indicadores deve ser contínua nessas instituições uma vez que foram encontrados dados incompatíveis com as metas estabelecidas ou com a média encontrada na rede.
Experiencia de Virtualización en la UNLPam
Authors: Filippi José Luis , Lafuente Guillermo , Ballesteros Carlos , Bertone Rodolfo
Published: October 2020

Las herramientas tecnológicas que irrumpen el contexto sociocultural, presentan un escenario educativo donde la innovación es la única constante, en el cual convergen actividades formativas tradicionales con prácticas educativas que incorporan dispositivos tecnológicos de última generación.  Gunther Kress considera que se debe enseñar a los estudiantes a incorporar diferentes medios de comunicación a través de los cuales se fomentan distintas habilidades retóricas, haciendo uso de diferentes plataformas [1]. Con el objetivo de extender el proceso formativo presencial de los estudiantes que cursan las materias Introducción a la Informática, Programación Procedural y Autómatas y Lenguajes, de las carreras Analista Programador e Ingeniería en Sistemas, se decide virtualizar dichas asignaturas en el contexto de la Facultad de Ingeniería de la Universidad Nacional de la Pampa. El objetivo es, facilitar el proceso de aprendizaje, permitir a los educandos acceder en cualquier momento y desde cualquier lugar a la información con un dispositivo tecnológico que posea conectividad a internet. A continuación, se presenta en este artículo la experiencia desarrollada.
GRAND DESIGN PERADILAN KHUSUS PEMILU DAN KEWENANGAN BAWASLU DALAM PENYELESAIAN SENGKETA PILKADA
Authors: Putra Hendra Setyadi Kurnia
Published: October 2020

Peraturan Pemerintah Pengganti Undang-Undang (PERPU) Nomor 1 Tahun 2014 Tentang Pemilihan Gubernur, Bupati dan Walikota mengatur model baru terkait prosesPilkada. Pilkada dilaksanakan secara serentak pada level Nasional. Berdasarkanmodel Pilkada yang dilaksanakan secara serentak ini tentu membutuhkan regulasilanjutan. Diantaranya pembentukan lembaga peradilan Pemilu. Permasalahan yangmuncul dalam penelitian ini adalah terkait bagaimana kewenangan Bawaslu dan peradilan pemilu dalam penyelesian sengketa pemilu. Penelitian ini dilakukan dengan metode penelitianhukum doktrinal dan non-doktrinal, dengan menganalis bahan-bahan hukum yangberkaitan dengan permasalahan. Berdasarkan penelitian ini diperoleh hasil bahwaperlu adanya revitalisasi terhadap kewenangan Bawaslu. Bawaslu akan berperansebagai penyidik dan penuntut umum dalam perkara pidana pilkada, sehinggakeberadaan Bawaslu Pasca terbentuknya Badan peradilan Pemilu akan berbedadengan yang sekarang. Artinya Bawaslu tidak lagi melakukan pengawasan aktif namunmelakukan penyidikan dan penuntutan atas perkara pidana proses pilkada, hal inidilakukan oleh bawaslu provinsi dan Bawaslu Kabupaten/kota, sehingga tugaspengawasan aktif dikembalikan kepada masyarakat. Karena tidak mungkin tugaspengawasan tetap dilakukan oleh Bawaslu dengan memperhatikan bahwa tidakmungkin peran pengawas sekaligus secara serta merta menjadi pengadil atau pemutusperkara.
Enrichment of common carp (Cyprinus carpio) diet with Malic acid: Effects on skin mucosal immunity, antioxidant defecne and growth performance
Authors: Safari Roghieh , Hoseinifar Seyed Hossein , Dadar Maryam
Published: October 2020

The present study investigated possible effects of dietary malic acid on the expression of immunity, antioxidant and growth related genes expression as well as skin mucus immune parameters in common carp. Common carp (Cyprinus carpio) fingerlings were fed diets supplemented with different levels (0 [control], 0.5%, 1%, 2%) of malic acid (MA) for 60 days. The results revealed highest expression levels of immune-related genes (tnf-alpha, il1b, il8 and lyz) in skin of common carp fed 2% MA (P < 0.05). Regarding 1% MA treatment comparison with control group, significant difference was noticed just in case of lyz (P < 0.05). Evaluation of growth related genes expression revealed no significant difference between treatments (P > 0.05). The study of antioxidant related genes (gsta and gpx) in common carp skin fed with MA, showed significant difference between treated groups and control (P < 0.05). Carps fed with 2% MA had highest alkaline phosphatase activity in skin mucus compared other treated groups and control (P < 0.05). There were no significant difference between 0.5% and 1% and control (P > 0.05). The study of total protein and total immunoglobulin (Ig) in common carp skin musus revealed no alteration following MA treatment (P > 0.05). The present data demonstrated that feeding with MA altered immune and antioxidant genes expression in skin mucus of common carp.
Chemical and Phytochemical Analyses of Extracts from the Leaves of Acalypha wilkesiana, “an Herbal Plant used for the Treatment of Various Skin Disorders”
Authors: Adejoke Osibote E. , Paulinus Nwafor S. , Omonigho Iluobe H.
Published: October 2020

Acalypha wilkesiana is a tropical herb used for the treatment of skin disorders. Phytochemical studies carried out on the pulverized dried leaves of the plant revealed the presence of alkaloids, cardiac glycosides, anthraquinones, saponins, flavonoids and tannins. The crude 50% methanol extract obtained from the dried leaves was sequentially partitioned into three fractions. Thin layer chromatography of the fractions revealed three (3) components each in hexane fraction; ethyl acetate fraction and butanol fraction of the plant extract. Column chromatography of the fractions was carried out. The infrared analyses of the components revealed the presence of alkenes, hydroxyl group, conjugate carbonyls, esters in the hexane fraction components. Those from the ethyl acetate and butanol fractions contained aliphatic amides or amines with carbonyl and esters attached in the two fractions. Essential oil was extracted from the dried leaves using hydro-distillation method. GC-MS analysis of the essential oil revealed the presence of major compounds which included: n-Hexadecanoic acid 4-Hexen-2-one-3-methyl, Pyrrole and 6-Benzamido-4-benzoyl-1,2,4-triazine-3,5. The presence of the functional groups inferred from IR and GC-MS analyses with the antimicrobial potential of the essential oil may support the use of the plant in the management of skin infections, gastrointestinal disorders and other ailments.
Multifunctional discriminant analysis of morphostructural traits in Nigerian locally adapted turkeys
Authors: Adenaike Adeyemi Sunday , Jegede Oluwatosin , Bello-Ibiyemi Abdulraheem Adedeji , Ikeobi Christian Obiora Ndubuisi
Published: October 2020

Association among biometric traits and characterisation based on sexed-plumage colour of Nigerian locally adapted turkey were investigated using discriminant analysis. Eight morphometric traits were measured to study their phenotypic variations between two plumage colours (Lavender and White). The characters measured were body weight (BW) as well as body dimensions such as wing length (WL), wing span (WS), body length (BL), breast girth (BG), shank length (SL), thigh length (TL) and keel length (KL) taken at 12 weeks of age. The White male turkey was significantly (P < 0.05) heavier and had longer morphometric body traits than its female counterpart, but when compared with the Lavender male and female genotype, the traits did not differ significantly (P > 0.05). High positive and significant (P < 0.05) correlation coefficients were recorded among the various body traits. Coefficients of correlation in Lavender turkey ranged from 0.73 – 0.94, and 0.84 – 0.96 in the White turkey. The highest association with body weight in Lavender was body length (r = 0.80, P < 0.05), and the trio of BW, TL and KL had the stronger association for the White turkey (r = 0.91, P < 0.05). The first, second and third canonical variable or Fisher linear discriminant function explained 52.13 %, 37.48 % and 10.39 %, respectively, of the total variation. The distances between all pair wise were significant (P < 0.05). The greatest distance value (415.16) was between the White male and female turkeys, closely followed by the male White and female Lavender turkey (303.58), while the least distance was between the male and female Lavender. The distance between the populations was significant. It can be concluded that thigh length, breast girth, wing length, wing span and body length can serve as the most discriminating variables in distinguishing between White and Lavender populations.
Weed control and productivity of maize (Zea mays L.) in Malete, Kwara State of Nigeria
Authors: Imoloame Emmanuel Oyamedan
Published: October 2020

The need to determine the minimum application rates of commonly used herbicides in Malete and the Guinea savanna of Nigeria for effective weed control and higher grain yield of maize, triggered this study. Therefore, field trials were conducted at the Teaching and Research Farm of Kwara State University, Malete, to determine the weed control method that will be more effective in controlling weeds and give higher grain yield and cash returns in the production of maize. The experiment consisted of 9 treatments viz: primextra (metolachlor plus atrazine) + 2,4-D at 1.5 + 1.5 kg active ingredient (a.i.).ha−1, primextra + 2,4-D at 2.0 + 2.0 kg a.i. ha−1, primextra + 2,4-D at 2.5 + 2.5 kg ha−1, primextra + nicosulfuron at 1.5 + 0.03 kg a.i. ha−1, primextra + nicosulfuron at 2.0 + 0.05 kg a.i. ha−1, primextra + niconsulfuron at 2.5 + 0.07 kg a.i. ha−1, primextra at 1.5 kg a.i. ha−1 + one Supplementary Hoe Weeding (SHW) at 6 Weeks After Sowing (WAS), two hand weeding at 3 and 6 Weeks After Sowing (WAS) and a weedy check. These treatments were laid out in randomised complete block design (RCBD) with three replicates. Data collected were subjected to analysis of variance using Statistical Analysis Software (SAS) package, after which means were separated using Duncan’s Multiple Range Test (DMRT). Results showed that treatment combinations of primextra + one SHW at 6 WAS, two hoe weeding at 3 and 6 WAS, primextra + 2,4-D at 2.0 + 2.0 kg a.i. ha−1 and primextra + nicosulfuron at 2.0+0.05 kg a.i. ha−1 gave effective weed control, higher grain yield and cash returns. Therefore, primextra at 1.5 kg a.i. ha−1 + one SHW at 6 WAS, primextra +2,4-D at 2.0 + 2.0 kg a.i. ha−1 and primextra + nicosulfuron at 2.0 + 0.05 kg a.i. ha−1 are recommended to farmers as alternative to two hoe weeding at 3 and 6 WAS.
Identifying Key Criteria for Quality Assessment of Landscape Architecture Projects
Authors: Stauskis Gintaras
Published: October 2020

the question of quality of modified landscape is critical for the client and the users and depends on the quality of projects. After theoretical and empirical research, the paper proposes the framework for quality assessment criteria and corresponding indicators for assessing landscape architecture projects. By thorough analysis of the recent international research and design and implementation practices in Lithuania, the paper gives the flexible and universal set of environmental, socio-economic, and aesthetic quality criteria and relevant indicators in the context of sustainable performance.
Defect Detection of Printed Fabric Based on RGBAAM and Image Pyramid
Authors: Jing Junfeng , Ren Huanhuan
Published: October 2020

To solve the problem of defect detection in printed fabrics caused by abundant colors and varied patterns, a defect detection method based on RGB accumulative average method (RGBAAM) and image pyramid matching is proposed. First, the minimum period of the printed fabric is calculated by the RGBAAM. Second, a Gaussian pyramid is constructed for the template image and the detected image by using the minimum period as a template. Third, the similarity measurement method is used to match the template image and the detected image. Finally, the position of the printed fabric defect is marked in the image to be detected by using the Laplacian pyramid restoration. The experimental results show that the method can accurately segment the printed fabric periodic unit and locate the defect position. The calculation cost is low for the method proposed in this article.
Comparative study of two Eucalyptus species from Algeria: chemical composition, toxicity and acaricidal effect on Varroa destructor
Authors: Atmani-Merabet Ghania , Fellah Sihem , Belkhiri Abdelmalik
Published: October 2020

Varroa destructor is an external parasitic mite that is a serious pest of honeybees and has caused severe losses of colonies worldwide. One of the feasible alternative treatments being used for their control is the application of essential oils, which are generally inexpensive and most pose few health risks. The investigation was designed to determine the chemical composition, toxicity and acaricidal effects of Eucalyptus amygdalina leaf essential oil (EaEO) grown in Algeria and to compare its activity on Varroa destructor with that of Eucalyptus globulus from the same region. Fresh leaves of E. amygdalina (Ea) by steam distillation yielded 0.77% (v/w), and investigation of the oil on GC/MS resulted in the identification of 35 compounds, with 1.8-cineole (35.78%) as most abundant constituent. Other notable compounds include spathulenol (12.58%), camphene (7.73%), α-pinene (4.38%), valencene (2.64%), while 2-carene and ledol (1.45%) were also among the constituents identified. The acaricidal features of the essential oil was evaluated using bee hives infected by Varroa destructor, and a significant effect of oil application was observed (p < 0.05). Cytotoxic effect was assayed using the brine shrimp lethality assay, Probit’s analysis of the result revealed an LC50 value of 116.06 μg/mL. Essential oil of E. amygdalina (EaEO) has potential acaricidal effect on Varroa destructor, but this effect is less important than the one recorded by E. globulus. Further studies are needed to determine the active component responsible for this effect.
The Confirmed Occurence of Serpent Eel Ophisurus serpens in Saros Bay (Northern Agean Sea), Turkey
Authors: Tuncer Sezginer , Koç Hatice Torcu , Zilifli Aytuğ
Published: October 2020

One mature female specimen of serpent eel Ophisurus serpens (Linnaeus, 1758) was caught by long line by a professional fisherman at a depth of about 45 m from Ece Bight, Saros Bay, north Aegean Sea on 15 February 2016. The species was previously reported without any morphometric and meristic characters from Saros Bay. Some biological characters, such as age and diameters of otolith and oocytes, are also given. In this study, the detailed morphomeristic features, which can contribute to the taxonomic studies of serpent eel from Turkish Seas, are presented.
Modern Trends in the Functioning of Grain-Product Subcomplex of the Agricultural Sector of Ukraine in the Context of Implementing Its External Economic Potential
Authors: Zrailo Ivan , Hynkevych Svitlana
Published: October 2020

Subject and purpose of work: The main purpose of the article is to research the state of grain-product subcomplex of the agro-industrial complex and identify the main trends in its functioning as a prerequisite for the implementation of the external economic potential of Ukraine.

Materials and methods: The research used methodical tools for analysis, construction of econometric models, as well as open information sources of the State Statistics Service of Ukraine.

Results: A set of factors (independent variables) were determined and the existence of theoretically their relationship with the production profitability of cereals and legumes (dependent variable) was substantiated. The regression equations for the investigated factors dependence were formed. The reliability of the econometric model was proved using Fisher’s criterion and Student’s t-criterion test.

Conclusions: To increase the external economic potential of the grain-product subcomplex of the agro-industrial complex, it is advisable to focus on building rational mechanisms for managing the identified determinants of efficiency ensuring of the latter.
The Role of Cultural Tourism in Development of Depressed Regions in Russia: The Case of Plyos, Ivanovo Region.
Authors: Savchenko Alexander , Borodina Tatiana
Published: October 2020

The article analyzes the impact of cultural tourism on the development of municipalities in depressed regions through case-study of the small town Plyos in Ivanovo oblast in Russia. The town-planning composition of Plyos is determined by the Volga river and the complex highly rugged relief. The unique combination of architecture and natural landscape makes the town and its surroundings attractive for cultural tourism development. The connection between the development of culture and tourism in Plyos has been noted since the beginning of the 1970s. Since then, from decade to decade, these spheres have constantly strengthened each other’s development. A number of market factors have been identified for effective involvement of historical heritage and cultural landscape in various types of cultural tourism and their transformation into a resource for sustainable development of the settlement. These market factors can be summarized into three groups: marketing, institutional and investment. The bet on market-based and diversified development of cultural tourism made by the authorities of the municipality and the region in 2005 has produced significant positive results by 2020. The structure of cultural tourism in Plyos has changed qualitatively, and the importance of event and creative tourism has grown significantly. Over the past 4–5 years, the tourist flow has changed radically in the direction of a significant increase in the share of individual and most solvent categories of tourists. Increasing the duration of cruise ship stay and lengthening the period of attendance in Plyos for individual tourists provides an increase in the load of tourist infrastructure in the summer season, and the boom in expensive seasonal real estate and the expansion of the offer of services for types of tourism related to cultural, contribute to leveling the seasonal load. However, these successes have a downside, when Plyos is an “island of prosperity” in the “economic desert” of its depressed regional environment. There are several ways in which it is possible to influence the development of a depressive surroundings. For the Ivanovo region, Plyos acts as a “point of entry” for investments in the tourism sector, a promoter of all-Russian events in the field of cultural tourism and a market place for products of local producers, including products of world-famous art crafts.
A history of varying methods for determining tree age in Estonia with emphasis on oak
Authors: Sander Heldur
Published: October 2020

This paper explores the history of age detection of trees, especially the age history of oak trees, throughout two centuries in Estonia. It was already in the beginning of the 19th century when relations between the size and age of oaks in northern Latvia (previous Livonian province) were described. The paper explains how the species concept of Quercus robur developed over time in the past and points out discussions on the existence of two varieties Q. robur L. var. tardiflora Czern and Q. robur L. var. praecox Czern. It also states that thanks to the use of the increment borer, the first dendrochronological studies were carried out in Estonia in the 1920s. Dendrochronological research in the Soviet Union began in the 1950s with Lithuania being the leading country in the field headed by Teodaras Bitvinskas. In Estonia, research was continued in the 1960s until now. The paper takes a look at the life of Mart Rohtla who introduced the method of determining tree age according to tree bark, presents his standpoints on oaks and critically assesses these. A comparative assessment is given on the ages of oak and lime trees found according to the tree-ring method and bark increment method. The great ages of the oaks and limes found by applying the bark increments method are doubted and considered unreliable. However, the age of the surface layers of the bark of oaks and limes needs clarification in the future.