bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Script Concordance Testing on Clinical Decision-Making in Paramedic Education
Authors: Naylor Katarzyna , Hislop Jane , Torres Kamil , Mani Zakaria A. , Goniewicz Krzysztof
Published: January 2024

This study investigates the effectiveness of the Script Concordance Test (SCT) in enhancing clinical reasoning skills within paramedic education. Focusing on the Medical University of Lublin, we evaluated the SCT’s application across two cohorts of paramedic students, aiming to understand its potential to improve decision-making skills in emergency scenarios. Our approach, informed by Van der Vleuten’s assessment framework, revealed that while the SCT’s correlation with traditional methods like multiple-choice questions (MCQs) was limited, its formative nature significantly contributed to improved performance in summative assessments. These findings suggest that the SCT can be an effective tool in paramedic training, particularly in strengthening cognitive abilities critical for emergency responses. The study underscores the importance of incorporating innovative assessment tools like SCTs in paramedic curricula, not only to enhance clinical reasoning but also to prepare students for effective emergency responses. Our research contributes to the ongoing efforts in refining paramedic education and highlights the need for versatile assessment strategies in preparing future healthcare professionals for diverse clinical challenges.
Integrative Transcriptomic and Metabolomic Analyses of the Mechanism of Anthocyanin Accumulation and Fruit Coloring in Three Blueberry Varieties of Different Colors
Authors: Chu Liwei , Du Qianhui , Li Aizhen , Liu Guiting , Wang Hexin , Cui Qingqing , Liu Zhichao , Liu Haixia , Lu Yani , Deng Yanqiong , Xu Guohui
Published: January 2024

Blueberries are recognized worldwide as one of the most important healthy foods due to their anthocyanins, which have special antioxidant properties. They have become a highly produced and valuable fruit crop. Most blueberry varieties are rich in anthocyanins, which impart a beautiful blue color; however, there are currently several blueberry varieties with different colors worldwide, and these special-colored varieties are the key to analyzing the coloring mechanism of blueberry fruit. Fruit color could be seen as an important nutritional quality trait in terms of marketing. In this study, a combination of transcriptomic and metabolomic analyses was performed on three representative blueberry varieties (‘Pink Popcorn’, ‘Chandler’, and ‘Black Pearl’) with pink, blue, and black fruits, respectively. The metabolomic results showed that the delphinium pigment is the dominant anthocyanin, which is the prerequisite for the formation of fruit color in blueberries. We identified 18 candidate structural genes in the anthocyanin biosynthesis pathway that were significantly up-regulated during three stages of fruit ripening in ‘Black Pearl’ and ‘Chandler’, but these were not found to be significantly expressed in ‘Pink Popcorn’ after combining the transcriptomic analysis results. The non-expression of the VcANS gene may lead to the pink color of the mature fruit of ‘Pink Popcorn’. The phylogenetic tree, heatmap analysis, and WGCNA analysis identified a candidate transcription factor, VcMYBA, which may regulate the differences between black and blue fruits in blueberries by regulating the expression level of multiple structural genes in the anthocyanin biosynthesis pathway. These results provide new insights into the mechanisms of anthocyanin accumulation and coloration in blueberries during fruit ripening and can help support production practices to improve fruit quality characteristics. The key candidate genes that regulate the fruit color differences among different blueberry varieties have the potential to enhance the antioxidant properties and quality characteristics of blueberries through future genomic editing.
The Use of Drought-Tolerant Vegetation on Green Roofs: A Method for the Digital Photographic Monitoring of Its Development
Authors: Rodrigues Madalena , Arsénio Pedro , Paço Teresa Afonso do
Published: January 2024

The increased number of buildings in urban areas limits the creation of vegetated areas, leading to the search for alternatives to create spaces to promote contact with nature. In this context, green roofs have been increasingly studied. These structures have specific microclimatic conditions requiring an accurate study of the most appropriate vegetation to use. This study aims to analyze the long-term viability of vegetation installed on an experimental green roof open-air lab. This analysis was performed using images obtained from photographic records and later inserted into the ImageJ program, in order to identify species and evaluate the area covered by vegetation. Only a few of the species that were planted in the test beds over the years have persisted to the present, while other species have spontaneously appeared. Also, surveys were used to learn about people’s preferences for the vegetation on these test beds. These showed that people favor recognizable plants with plenty of vibrantly colored blossoms. It is feasible to choose the best plants for green roofs in the studied conditions as a result of this analysi sconsidering the ground cover percentage by vegetation, its persistence, and the preferences of the respondents.
Management Information Systems for Tree Fruit—1: A Review
Authors: Dhonju Hari Krishna , Walsh Kerry Brian , Bhattarai Thakur
Published: January 2024

A farm management information system (MIS) entails record keeping based on a database management system, typically using a client-server architecture, i.e., an information system, IS, coupled with a variety of tools/methods/models for the support of operational management. The current review adopts a multivocal approach to consider academic and commercial developments in MISs for orchard management, based primarily on the refereed literature but extending to grey literature and interviews of Australian mango orchard managers. Drivers for orchard MIS development include increasing the orchard size and management complexity, including regulatory requirements around labour, chemical spray use and fertilisation. The enablers include improvements in within-orchard communications, distributed (web) delivery systems using desktop and mobile devices, and sensor systems and predictive models, e.g., for pest management. Most orchard MIS-related publications target the commodities of apple, grape, mango and olive in the context of management of plant health (pest and disease), plant development, irrigation and labour management. Harvest forecast and MIS modules are only now beginning to emerge, in contrast to a long history of use in grain production. The commercial systems trend towards an incorporation of financial information, an integration of data from multiple sources and a provision of dashboards that are tailored to the user. Requirements for industry adoption of a MIS are discussed in terms of technical and design features, with a focus on usability and scalability.
Intestinal Inflammation and Regeneration–Interdigitating Processes Controlled by Dietary Lipids in Inflammatory Bowel Disease
Authors: Kwon Soon Jae , Khan Muhammad Sohaib , Kim Sang Geon
Published: January 2024

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a disease of chronic inflammatory conditions of the intestinal tract due to disturbance of the inflammation and immune system. Symptoms of IBD include abdominal pain, diarrhea, bleeding, reduced weight, and fatigue. In IBD, the immune system attacks the intestinal tract’s inner wall, causing chronic inflammation and tissue damage. In particular, interlukin-6 and interlukin-17 act on immune cells, including T cells and macrophages, to amplify the immune responses so that tissue damage and morphological changes occur. Of note, excessive calorie intake and obesity also affect the immune system due to inflammation caused by lipotoxicity and changes in lipids supply. Similarly, individuals with IBD have alterations in liver function after sustained high-fat diet feeding. In addition, excess dietary fat intake, along with alterations in primary and secondary bile acids in the colon, can affect the onset and progression of IBD because inflammatory cytokines contribute to insulin resistance; the factors include the release of inflammatory cytokines, oxidative stress, and changes in intestinal microflora, which may also contribute to disease progression. However, interfering with de novo fatty acid synthase by deleting the enzyme acetyl-CoA-carboxylase 1 in intestinal epithelial cells (IEC) leads to the deficiency of epithelial crypt structures and tissue regeneration, which seems to be due to Lgr5+ intestinal stem cell function. Thus, conflicting reports exist regarding high-fat diet effects on IBD animal models. This review will focus on the pathological basis of the link between dietary lipids intake and IBD and will cover the currently available pharmacological approaches.
The Overexpression of Zea mays Strigolactone Receptor Gene D14 Enhances Drought Resistance in Arabidopsis thaliana L.
Authors: Zhang Chen , Wang Fanhao , Jiao Peng , Liu Jiaqi , Zhang Honglin , Liu Siyan , Guan Shuyan , Ma Yiyong
Published: January 2024

Strigolactones (SLs) represent a recently identified class of plant hormones that are crucial for plant tillering and mycorrhizal symbiosis. The D14 gene, an essential receptor within the SLs signaling pathway, has been well-examined in crops, like rice (Oryza sativa L.) and Arabidopsis (Arabidopsis thaliana L.), yet the research on its influence in maize (Zea mays L.) remains scarce. This study successfully clones and establishes Arabidopsis D14 gene overexpression lines (OE lines). When compared with the wild type (WT), the OE lines exhibited significantly longer primary roots during germination. By seven weeks of age, these lines showed reductions in plant height and tillering, alongside slight decreases in rosette and leaf sizes, coupled with early aging symptoms. Fluorescence-based quantitative assays indicated notable hormonal fluctuations in OE lines versus the WT, implying that D14 overexpression disrupts plant hormonal homeostasis. The OE lines, exposed to cold, drought, and sodium chloride stressors during germination, displayed an especially pronounced resistance to drought. The drought resistance of OE lines, as evident from dehydration–rehydration assays, outmatched that of the WT lines. Additionally, under drought conditions, the OE lines accumulated less reactive oxygen species (ROS) as revealed by the assessment of the related physiological and biochemical parameters. Upon confronting the pathogens Pseudomonas syringae pv. tomato DC3000 (Pst DC3000), post-infection, fluorescence quantitative investigations showed a significant boost in the salicylic acid (SA)-related gene expression in OE lines compared to their WT counterparts. Overall, our findings designate the SL receptor D14 as a key upregulator of drought tolerance and a regulator in the biotic stress response, thereby advancing our understanding of the maize SL signaling pathway by elucidating the function of the pivotal D14 gene.
The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial
Authors: Candás-Estébanez Beatriz , Fernández-Cidón Bárbara , Corbella Emili , Tebé Cristian , Fanlo-Maresma Marta , Esteve-Luque Virginia , Salas-Salvadó Jordi , Fitó Montserrat , Riera-Mestre Antoni , Ros Emilio , Pintó Xavier
Published: January 2024

Metabolic syndrome (MetS) is associated with alterations of lipoprotein structure and function that can be characterized with advanced lipoprotein testing (ADLT). The effect of the Mediterranean diet (MedDiet) and weight loss on the lipoprotein subclass profile has been scarcely studied. Within the PREDIMED-Plus randomized controlled trial, a sub-study conducted at Bellvitge Hospital recruiting center evaluated the effects of a weight loss program based on an energy-reduced MedDiet (er-MedDiet) and physical activity (PA) promotion (intervention group) compared with energy-unrestricted MedDiet recommendations (control group) on ADLT-assessed lipoprotein subclasses. 202 patients with MetS (n = 107, intervention; n = 95, control) were included. Lipid profiles were determined, and ADLT was performed at baseline, 6, and 12 months. Linear mixed models were used to assess the effects of intervention on lipoprotein profiles. Compared to the control diet, at 12 months, the er-MedDiet+PA resulted in a significant additional 4.2 kg of body weight loss, a decrease in body mass index by 1.4 kg/m2, reduction in waist circumference by 2.2 cm, decreased triglycerides, LDL-cholesterol and non-HDL-cholesterol, and increased HDL-cholesterol. In er-MedDiet+PA participants, ADLT revealed a decrease in small dense-LDL-cholesterol (sd-LDL-C), intermediate-density lipoproteins, VLDL-triglyceride, and HDL-Triglyceride, and an increase in large LDL and large VLDL particles. In conclusion, compared to an ad libitum MedDiet (control group), er-MedDiet+PA decreased plasma triglycerides and the triglyceride content in HDL and VLDL particles, decreased sd-LDL-C, and increased large LDL particles, indicating beneficial changes against cardiovascular disease.
Methodology for Assessing the Technical Condition and Durability of Bridge Structures
Authors: Medvediev Kostiantyn , Kharchenko Anna , Stakhova Anzhelika , Yevseichyk Yurii , Tsybulskyi Vitalii , Bekö Adrián
Published: January 2024

The proposed methodology aims to determine and forecast the technical condition of bridge elements, which could serve as an advanced engineering tool for assessing reliability and durability. It is developed based on fundamental studies that synthesize the experience of studying the physical–mechanical and physical–chemical properties of materials in bridge structures operating under real conditions. The theoretical foundation of the methodology is a reliability model and residual lifetime prediction of bridge elements based on Markov’s theory. The developed methodology is designed for assessing the technical condition of individual bridge elements, followed by a comprehensive evaluation of the entire structure. Reliability during operation is adopted as the indicator of technical condition. This quantitative reliability indicator in the model serves as a criterion for evaluating the safety level of bridge elements; ranking of bridge elements as necessary for specific types of repair, reconstruction, or replacement; strategic planning of expenditures for repair or reconstruction under limited funding; and forecasting the remaining resource of elements. An evaluation and prediction algorithm for the technical condition of bridges is proposed for the application of the developed methodology. A mathematical experiment of the developed methodology was conducted, which confirmed the adequacy of the proposed hypothesis, i.e., the use of the reliability model and the prediction of residual lifetime of bridge elements. First, a three-step mechanism for refining the technical condition of the bridge is proposed, significantly enhancing the accuracy of the calculations. Therefore, the developed methodology holds practical value and can serve as a basis for information-analytical systems for managing the condition of bridges.
Self-Cleaning and Charge Transport Properties of Foils Coated with Acrylic Paint Containing TiO2 Nanoparticles
Authors: Armaković Sanja J. , Savanović Maria M. , Šiljegović Mirjana V. , Kisić Milica , Šćepanović Maja , Grujić-Brojčin Mirjana , Simić Nataša , Gavanski Lazar , Armaković Stevan
Published: January 2024

The study comprehensively investigates the design and performance of self-cleaning surfaces fabricated by coating aluminum foil with an acrylic paint matrix enriched with different content of titanium dioxide (TiO2) nanoparticles. The main goal was to assess the self-cleaning characteristics of the surfaces obtained. This study employs scanning electron microscopy (SEM) to analyze the morphology of TiO2-modified acrylic surfaces, revealing spherical particles. Raman spectroscopy elucidates signatures characterizing TiO2 incorporation within the acrylic matrix, providing comprehensive insights into structural and compositional changes for advanced surface engineering. Alternating current (AC) impedance spectroscopy was used to assess selected charge transport properties of produced self-cleaning surfaces, allowing us to gain valuable insights into the material’s conductivity and its potential impact on photocatalytic performance. The self-cleaning properties of these tiles were tested against three frequently used textile dyes, which are considered to pose a serious environmental threat. Subsequently, improving self-cleaning properties was achieved by plasma treatment, utilizing a continuous plasma arc. The plasma treatment led to enhanced charge separation and surface reactivity, crucial factors in the self-cleaning mechanism. To deepen our comprehension of the reactive properties of dye molecules and their degradation dynamics, we employed a combination of density functional tight binding (DFTB) and density functional theory (DFT) calculations. This investigation lays the foundation for advancing self-cleaning materials with extensive applications, from architectural coatings to environmental remediation technologies.
Double Photodiode Readout System for the Calorimeter of the HERD Experiment: Challenges and New Horizons in Technology for the Direct Detection of High-Energy Cosmic Rays
Authors: Betti Pietro , Adriani Oscar , Antonelli Matias , Bai Yonglin , Bai Xiaohong , Bao Tianwei , Berti Eugenio , Bonechi Lorenzo , Bongi Massimo , Bonvicini Valter , Bottai Sergio , Cao Weiwei , Casaus Jorge , Chen Zhen , Cui Xingzhu , D’Alessandro Raffaello , Detti Sebastiano , Diaz Carlos , Dong Yongwei , Finetti Noemi , Formato Valerio , Frutos Miguel Angel Velasco , Gao Jiarui , Giovacchini Francesca , Liang Xiaozhen , Li Ran , Liu Xin , Lyu Linwei , Martinez Gustavo , Mori Nicola , Munoz Jesus Marin , Pacini Lorenzo , Papini Paolo , Pizzolotto Cecilia , Quan Zheng , Qin Junjun , Shi Dalian , Starodubtsev Oleksandr , Tang Zhicheng , Tiberio Alessio , Vagelli Valerio , Vannuccini Elena , Wang Bo , Wang Junjing , Wang Le , Wang Ruijie , Zampa Gianluigi , Zampa Nicola , Wang Zhigang , Xu Ming , Zhang Li , Zheng Jinkun
Published: January 2024

The HERD experiment is a future experiment for the direct detection of high-energy cosmic rays and is to be installed on the Chinese space station in 2027. The main objectives of HERD are the first direct measurement of the knee of the cosmic ray spectrum, the extension of electron+positron flux measurement up to tens of TeV, gamma ray astronomy, and the search for indirect signals of dark matter. The main component of the HERD detector is an innovative calorimeter composed of about 7500 LYSO scintillating crystals assembled in a spherical shape. Two independent readout systems of the LYSO scintillation light will be installed on each crystal: the wavelength-shifting fibers system developed by IHEP and the double photodiode readout system developed by INFN and CIEMAT. In order to measure protons in the cosmic ray knee region, we must be able to measure energy release of about 250 TeV in a single crystal. In addition, in order to calibrate the system, we need to measure typical releases of minimum ionizing particles that are about 30 MeV. Thus, the readout systems should have a dynamic range of about 107. In this article, we analyze the development and the performance of the double photodiode readout system. In particular, we show the performance of a prototype readout by the double photodiode system for electromagnetic showers as measured during a beam test carried out at the CERN SPS in October 2021 with high-energy electron beams.
Comparison of Mid-Term Prognosis in Intermediate-to-Low-Risk Contemporary Population with Guidelines-Oriented Age Cutoff
Authors: Benenati Stefano , Gallo Francesco , Kim Won-keun , Khokhar Arif A. , Zeus Tobias , Toggweiler Stefan , Galea Roberto , De Marco Federico , Mangieri Antonio , Regazzoli Damiano , Reimers Bernhard , Nombela-Franco Luis , Barbanti Marco , Regueiro Ander , Piva Tommaso , Rodes-Cabau Josep , Porto Italo , Colombo Antonio , Giannini Francesco , Sticchi Alessandro
Published: January 2024

Background: Current European guidelines support transcatheter aortic valve implantation (TAVI) in intermediate-to-low-risk patients ≥75 years-old, but its prognostic relevance is unknown. Methods: Intermediate-to-low-risk (The Society of Thoracic Surgeons score <8%) patients enrolled in the HORSE registry were included. We compared the populations aged under 75 with those over 75. The primary endpoint was all-cause mortality. Results: A total of 2685 patients were included: 280 (8.6%) < 75 and 2405 ≥ 75 years. Through a mean follow-up of 437 ± 381 days, 198 (8.2%) and 23 (8.2%) patients died in the two arms without statistically significant differences (log-rank p = 0.925). At Cox regression analysis, age did not predict the occurrence of all-cause death, neither as a continuous variable (HR 1.01, 95% CI 0.99–1.04, p = 0.294) nor dichotomizing according to the prespecified cutoff of 75 years (HR 0.97, 95% CI 0.63–1.51, p = 0.924). Time-to-event ROC curves showed low accuracy of age to predict all-cause mortality (area under the curve of 0.54 for both 1-year and 2-year outcomes). Conclusions: TAVI has comparable benefits across age strata for intermediate-to-low-risk patients. The age cutoff suggested by the current guidelines is not predictive of the risk of adverse events during hospital stays or of all-cause mortality through a mid-term follow-up.
Early Effects of a Pain-Informed Movement Program in Patients with Post-COVID-19 Condition Experiencing Persistent Pain: Protocol for a Randomized Controlled Trial
Authors: Calvache-Mateo Andrés , López-López Laura , Heredia-Ciuró Alejandro , Martín-Núñez Javier , Valenza-Peña Geraldine , Cabrera-Martos Irene , Valenza Marie Carmen
Published: January 2024

(1) Background: The COVID-19 pandemic has generated 771 million confirmed cases. Of these patients, 60% have developed persistent symptoms including pain. This pain is a complex symptom that needs comprehensive therapeutic strategies to address it holistically. The main objective of this study will be to evaluate the early impact of the Pain Informed Movement (PIM) program in patients with post-COVID-19 conditions experiencing new-onset persistent pain. (2) Methods: A randomized, single-blind clinical trial will be performed. Patients will be randomly assigned (1:1) to the experimental or control group. The experimental group will undergo a PIM program consisting of low-intensity functional exercises, pain neuroscience education, and relaxation techniques. The control group will receive no intervention. (3) Results: The results will be published as a peer-reviewed article. (4) Conclusions: This study will provide a basis for future research to support the implementation of comprehensive therapeutic approaches in the care of patients with post-COVID-19 persistent pain.
The Role of Automated Infrared Pupillometry in Traumatic Brain Injury: A Narrative Review
Authors: Vrettou Charikleia S. , Fragkou Paraskevi C. , Mallios Ioannis , Barba Chrysanthi , Giannopoulos Charalambos , Gavrielatou Evdokia , Dimopoulou Ioanna
Published: January 2024

Pupillometry, an integral component of neurological examination, serves to evaluate both pupil size and reactivity. The conventional manual assessment exhibits inherent limitations, thereby necessitating the development of portable automated infrared pupillometers (PAIPs). Leveraging infrared technology, these devices provide an objective assessment, proving valuable in the context of brain injury for the detection of neuro-worsening and the facilitation of patient monitoring. In cases of mild brain trauma particularly, traditional methods face constraints. Conversely, in severe brain trauma scenarios, PAIPs contribute to neuro-prognostication and non-invasive neuromonitoring. Parameters derived from PAIPs exhibit correlations with changes in intracranial pressure. It is important to acknowledge, however, that PAIPs cannot replace invasive intracranial pressure monitoring while their widespread adoption awaits robust support from clinical studies. Ongoing research endeavors delve into the role of PAIPs in managing critical neuro-worsening in brain trauma patients, underscoring the non-invasive monitoring advantages while emphasizing the imperative for further clinical validation. Future advancements in this domain encompass sophisticated pupillary assessment tools and the integration of smartphone applications, emblematic of a continually evolving landscape.
Maxillofacial Morphology as a Predictive Factor for Caries Risk in Orthodontic Patients: A Cross-Sectional Study
Authors: Koizumi Yuma , Kunimatsu Ryo , Kado Isamu , Yoshimi Yuki , Yamada Sakura , Ogasawara Tomohiro , Tanimoto Kotaro
Published: January 2024

This cross-sectional study aimed to explore the correlation between maxillofacial morphology and caries risk, assessed using salivary tests, in orthodontic patients. Despite enhancing the oral health-related quality of life, orthodontic treatment may adversely affect oral hygiene and increase caries risk. This study included 1071 patients all of whom underwent orthodontic examinations and salivary tests before starting orthodontic treatment at a hospital. Salivary tests were performed to assess the secretion rate, pH, buffering capacity, and counts of cariogenic bacteria. The maxillofacial morphology was evaluated using cephalometric X-rays and dental models. Statistical analyses revealed significant correlations among salivary characteristics, bacterial scores, and maxillofacial morphology. Notably, the facial angle and Y-axis values were associated with salivary secretion (p < 0.001), pH (p < 0.001), buffering capacity (p < 0.05), and cariogenic bacterial scores (p < 0.01), respectably. In conclusion, assessing the maxillofacial morphology before orthodontic treatment may aid in predicting the risk of bacterial oral diseases, offering valuable insights into personalized preventive measures. These findings underscore the potential for comprehensive evaluations to enhance caries risk assessment in orthodontic patients.
Effect of Ultraviolet Radiation on the Enzymolytic and Biomechanical Profiles of Abdominal Aortic Adventitia Tissue
Authors: Arbănaşi Emil-Marian , Russu Eliza , Arbănaşi Eliza-Mihaela , Ciucanu Constantin Claudiu , Mureșan Adrian Vasile , Suzuki Shuko , Chirilă Traian V.
Published: January 2024

Background: The abdominal aortic aneurysm (AAA) is defined as an increase in aortic diameter by more than 50% and is associated with a high risk of rupture and mortality without treatment. The aim of this study is to analyze the role of aortic adventitial collagen photocrosslinking by UV-A irradiation on the biomechanical profile of the aortic wall. Methods: This experimental study is structured in two parts: the first part includes in vitro uniaxial biomechanical evaluation of porcine adventitial tissue subjected to either short-term elastolysis or long-term collagenolysis in an attempt to duplicate two extreme situations as putative stages of aneurysmal degeneration. In the second part, we included biaxial biomechanical evaluation of in vitro human abdominal aortic adventitia and human AAA adventitia specimens. Biomechanical profiles were examined for porcine and human aortic tissue before and after irradiation with UV-A light (365 nm wavelength). Results: On the porcine aortic sample, the enhancing effect of irradiation was evident both on the tissue subjected to elastolysis, which had a high collagen-to-elastin ratio, and on the tissue subjected to prolonged collagenolysis despite being considerably depleted in collagen. Further, the effect of irradiation was conclusively demonstrated in the human adventitia samples, where significant post-irradiation increases in Cauchy stress (longitudinal axis: p = 0.001, circumferential axis: p = 0.004) and Young’s modulus (longitudinal axis: p = 0.03, circumferential axis: p = 0.004) were recorded. Moreover, we have a stronger increase in the strengthening of the AAA adventitia samples following the exposure to UV-A irradiation (p = 0.007) and a statistically significant but not very important increase (p = 0.021) regarding the stiffness in the circumferential axis. Conclusions: The favorable effect of UV irradiation on the strength and stiffness of degraded aortic adventitia in experimental situations mimicking early and later stages of aneurysmal degeneration is essential for the development and potential success of procedures to prevent aneurysmal ruptures. The experiments on human normal and aneurysmal adventitial tissue confirmed the validity and potential success of a procedure based on exposure to UV-A radiation.
Classification and Definitions of Compensatory Protective Step Strategies in Older Adults: A Scoping Review
Authors: Melo-Alonso Maria , Murillo-Garcia Alvaro , Leon-Llamas Juan Luis , Villafaina Santos , Gomez-Alvaro Mari Carmen , Morcillo-Parras Felipe Alejandro , Gusi Narcis
Published: January 2024

Background: The risk for an unexpected fall can be due to increasing age, health conditions, and loss of cognitive, sensory, or musculoskeletal functions. Falls have personal and economic consequences in many countries. Different disturbances can occur during gait, such as tripping, slipping, or other unexpected circumstances that can generate a loss of balance. The strategies used to recover balance depend on many factors, but selecting a correct response strategy influences the success of balance recovery. Objectives: (1) To collect and clarify the definitions of compensatory protective step strategies to recover balance in older adults; (2) to identify the most used methods to induce loss of balance; and (3) to identify the most used spatiotemporal variables in analyzing these actions. Methods: The present review has followed the PRISMA guideline extension for Scoping Review (PRISMA-ScR) and the phases proposed by Askery and O’Malley. The search was conducted in three databases: PubMed, Web of Science, and Scopus. Results: A total of 525 articles were identified, and 53 studies were included. Forty-five articles were quasi-experimental studies, six articles were randomized controlled trials, and two studies had an observational design. In total, 12 compensatory protective step strategies have been identified. Conclusions: There are 12 compensatory protective step strategies: lowering and elevating strategy, short- and long-step strategy, backward and forward stepping for slip, single step, multiple steps, lateral sidesteps or loaded leg sidestep unloaded leg sidestep, crossover step (behind and front), and medial sidestep. To standardize the terminology applied in future studies, we recommend collecting these strategies under the term of compensatory protective step strategies. The most used methods to induce loss of balance are the tether-release, trip, waist-pull, and slip methods. The variables analyzed by articles are the number of steps, the acceleration phase and deceleration phase, COM displacement, the step initiation or step duration, stance phase time, swing phase time and double-stance duration, stride length, step length, speed step, speed gait and the type of step.
Continence Is Not Affected after Sling Revision with Transvaginal Tape Elongation for Post-Sling Voiding Dysfunction
Authors: Tsai Ching-Pei , Liu Chih-Ku , Yang Evelyn , Ying Tsung-Ho , Chen Gin-Den , Hung Man-Jung
Published: January 2024

Voiding dysfunction (VD) after sling operation is not uncommon. Sling revisions by incision/excision are usually effective; however, they may result in recurrent stress urinary incontinence (SUI). We aimed to evaluate continence status after an innovative sling revision procedure that preserves the integrity of the sling. Patients who underwent either a single-incision (AJUST) or a trans-obturator (TVT-O) mid-urethral sling were studied. Transvaginal tape elongation (i.e., sling midline incision and mesh interposition) was performed on patients with post-sling VD. Factors that may affect recurrent SUI were investigated by statistical analyses. Of 119 patients, 90 (75.6%) (45 AJUST and 45 TVT-O) were available for long-term (median 9; 8–10 years) follow-up. A significantly higher rate (17.2% vs. 3.3%, p = 0.014) of VD was noted after AJUST (N = 10) than after TVT-O (N = 2). After sling revision, four (33%) of the 12 cases reported recurrent SUI, which was not significantly different (p = 1.000) from the rate (37%, 29/78) of patients who did not undergo sling revision. Further statistical analyses revealed no significant predisposing factors affecting the recurrence of SUI. Surgical continence did not seem to be affected by having had sling revision with transvaginal tape elongation for post-sling VD.
Effects of Topological Parameters on Thermal Properties of Carbon Nanotubes via Molecular Dynamics Simulation
Authors: Najmi Lida , Hu Zhong
Published: January 2024

Due to their unique properties, carbon nanotubes (CNTs) are finding a growing number of applications across multiple industrial sectors. These properties of CNTs are subject to influence by numerous factors, including the specific chiral structure, length, type of CNTs used, diameter, and temperature. In this topic, the effects of chirality, diameter, and length of single-walled carbon nanotubes (SWNTs) on the thermal properties were studied using the reverse non-equilibrium molecular dynamics (RNEMD) method and the Tersoff interatomic potential of carbon–carbon based on the Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS). For the shorter SWNTs, the effect of chirality on the thermal conductivity is more obvious than for longer SWNTs. Thermal conductivity increases with increasing chiral angle, and armchair SWNTs have higher thermal conductivity than that of zigzag SWNTs. As the tube length becomes longer, the thermal conductivity increases while the effect of chirality on the thermal conductivity decreases. Furthermore, for SWNTs with longer lengths, the thermal conductivity of zigzag SWNTs is higher than that of the armchair SWNTs. Thermal resistance at the nanotube–nanotube interfaces, particularly the effect of CNT overlap length on thermal resistance, was studied. The simulation results were compared with and in agreement with the experimental and simulation results from the literature. The presented approach could be applied to investigate the properties of other advanced materials.
Conscientiousness, Students’ Goal Orientation, and Reasoning Ability: Significance for Educational Standards
Authors: Weiss Selina , Böhnisch Martin
Published: January 2024

Previous studies show that students’ goal orientation and conscientiousness are related to academic performance. Few studies, however, allow conclusions to be drawn about the factor structure of goal orientation and its distinctions from conscientiousness. In a study with N = 145 secondary school students (M = 13.9, SD = 0.85; 41% male), we investigated if the residuals of latent factors of goal orientation are still meaningfully correlated with academic performance and reasoning. Based on structural equation models, we have replicated the theoretically derived four-factor structure and showed that conscientiousness explains 29% of the variance in learning goals and 40% of the variance in work avoidance. Furthermore, we show that the residuals of goal orientation are mainly not significantly related to reasoning or educational standards (only work avoidance correlated with reasoning, and performance goals correlated with educational standards). Educational standards were highly correlated with reasoning. Implications for school practice and possible interventions are discussed.
Terminal Phase Navigation for AUV Docking: An Innovative Electromagnetic Approach
Authors: Gutnik Yevgeni , Groper Morel
Published: January 2024

This study introduces a groundbreaking approach for real-time 3D localization, specifically focusing on achieving seamless and precise localization during the terminal guidance phase of an autonomous underwater vehicle (AUV) as it approaches an omnidirectional docking component in an automated deployable launch and recovery system (LARS). Using the AUV’s magnetometer, an economical electromagnetic beacon embedded in the docking component, and an advanced signal processing algorithm, this novel approach ensures the accurate localization of the docking component in three dimensions without the need for direct line-of-sight contact. The method’s real-time capabilities were rigorously evaluated via simulations, prototype experiments in a controlled lab setting, and extensive full-scale pool experiments. These assessments consistently demonstrated an exceptional average positioning accuracy of under 3 cm, marking a significant advancement in AUV guidance systems.
Dipole Oscillations along Principal Coordinates in a Frozen Channel in the Context of Symmetric Linear Thickness of Porous Ice
Authors: Shishmarev Konstantin , Sibiryakova Tatyana , Naydenova Kristina , Khabakhpasheva Tatyana
Published: January 2024

The problem of periodic oscillations of a dipole, specifically its strength, along the principal axes in a three-dimensional frozen channel is considered. The key points of the problem are taking into account the linear thickness of ice across the channel and ice porosity within Darcy’s law. The fluid in the channel is inviscid and incompressible; the flow is potential. It is expected that the oscillations of a small radius dipole well approximate the oscillations of a small radius sphere at a sufficient depth of immersion of the dipole. It was found that during oscillations along the channel and vertical oscillations, waves are generated in the channel, propagating along the channel with a frequency equal to the frequency of dipole oscillations. These waves decay far from the dipole, and the rate of decay depends on the porosity coefficient.
Multilocus Phylogeny and Characterization of Five Undescribed Aquatic Carnivorous Fungi (Orbiliomycetes)
Authors: Zhang Fa , Yang Yao-Quan , Zhou Fa-Ping , Xiao Wen , Boonmee Saranyaphat , Yang Xiao-Yan
Published: January 2024

The diversity of nematode-trapping fungi (NTF) holds significant theoretical and practical implications in the study of adaptive evolution and the bio-control of harmful nematodes. However, compared to terrestrial ecosystems, research on aquatic NTF is still in its early stages. During a survey of NTF in six watersheds in Yunnan Province, China, we isolated 10 taxa from freshwater sediment. Subsequent identification based on morphological and multigene (ITS, TEF1-α, and RPB2) phylogenetic analyses inferred they belong to five new species within Arthrobotrys. This paper provides a detailed description of these five novel species (Arthrobotrys cibiensis, A. heihuiensis, A. jinshaensis, A. yangbiensis, and A. yangjiangensis), contributing novel insights for further research into the diversity of NTF and providing new material for the biological control of aquatic harmful nematodes. Additionally, future research directions concerning aquatic NTF are also discussed.
Integrated Genome Sequencing and Transcriptome Analysis Identifies Candidate Pathogenicity Genes from Ustilago crameri
Authors: Liang Juan , Yin Desuo , Shu Xinyue , Xiang Ting , Zhang Chao , Li Honglian , Wang Aijun
Published: January 2024

Ustilago crameri is a pathogenic basidiomycete fungus that causes foxtail millet kernel smut (FMKS), a devastating grain disease in most foxtail-millet-growing regions of the world. Here, we report an assembled high-quality genome sequence of U. crameri strain SCZ-6 isolated from the diseased grains of foxtail millet in Changzhi, Shanxi Province, China. The genome size is 19.55 Mb, consisting of 73 contigs (N50 = 840,209 bp) with a G + C content of 54.09%, and encoding 6576 predicted genes and 6486 genes supported by RNA-seq. Evolutionarily, U. crameri lies close to the barley smut U. hordei, and an obvious co-linearity was observed between these two smut fungi. We annotated the genome of U. crameri strain SCZ-6 using databases, identifying 1827 pathogen–host interaction (PHI)-associated genes, 1324 genes encoding fungal virulence factors, 259 CAZy-related genes, 80 genes encoding transporters, and 206 putative cytochrome P450 genes; their expression profiles at different inoculation time points were also detected. Additionally, 70 candidate pathogen effectors were identified according to their expression patterns and predicted functions. In summary, our results provide important insights into the pathogenic mechanisms of the pathogenesis-related genes of U. crameri and a robust foundation for further investigation.
Genetic Analysis of Candida albicans Filamentation by the Iron Chelator BPS Reveals a Role for a Conserved Kinase—WD40 Protein Pair
Authors: Pinsky Mariel , Kornitzer Daniel
Published: January 2024

Candida albicans is a major human pathogenic fungus that is distinguished by its capability to switch from a yeast to a hyphal morphology under different conditions. Here, we analyze the cellular effects of high concentrations of the iron chelator bathophenanthroline disulfonate (BPS). BPS inhibits cellular growth by withholding iron, but when iron chelation is overcome by the addition of hemoglobin as an iron source, the cells resume growth as hyphae. The BPS hyphal induction pathway was characterized by identifying the hyphal-specific transcription factors that it requires and by a forward genetic screen for mutants that fail to form hyphae in BPS using a transposon library generated in a haploid strain. Among the mutants identified are the DYRK1-like kinase Yak1 and Orf19.384, a homolog of the DYRK1-associated protein WDR68/DCAF7. Orf19.384 nuclear localization depends on Yak1, similar to their mammalian counterparts. We identified the hyphal suppressor transcription factor Sfl1 as a candidate target of Yak1-Orf19.384 and show that Sfl1 modification is similarly affected in the yak1 and orf19.384 mutant strains. These results suggest that DYRK1/Yak1 and WDR68/Orf19.384 represent a conserved protein pair that regulates cell differentiation from fungi to animals.
A Comprehensive Approach to Bankruptcy Risk Evaluation in the Financial Industry
Authors: Issa Samar , Bizel Gulhan , Jagannathan Sharath Kumar , Gollapalli Sri Sarat Chaitanya
Published: January 2024

The study presents a comprehensive approach to examining the potential risk of bankruptcies in financial sector organizations. This investigation explores 20 financial sector entities and evaluates their fiscal history from 2000 to 2018. The developed model assesses the chance of these companies going bankrupt by analyzing indicators like liquidity, profitability, debt composition, and operational effectiveness. These metrics are contrasted to regulatory requirements and assessed as having low, moderate, or elevated risk repercussions, ultimately contributing to an overall threat rating. Additionally, the model has a unique algorithm that compensates for excessive debt levels, strengthening the reliability of the risk appraisal grade. This straightforward instrument illustrates the demand to incorporate a variety of financial health indicators. According to the findings, excessive amounts of debt have a detrimental influence on profitability, leading to decreased stock returns and a greater probability of bankruptcy. These findings have practical implications for investors and stakeholders, providing insightful information to help inform decision-making, especially during periods of economic unpredictability such as pandemics. Furthermore, they encourage the enhancement of financial market efficiency.
Residential Micro-Segregation and Social Capital in Lima, Peru
Authors: Calderón-Figueroa Fernando
Published: January 2024

This article addresses the bidirectional relationship between residential micro-segregation, in the form of built barriers to mobility, and social capital. I engage with two bodies of the literature. On the one hand, I critique a widespread top-down model of residential segregation. This model suggests that higher-status groups drive segregation through direct (e.g., secluded neighbourhoods) and indirect (e.g., by funnelling housing demand) measures. On the other hand, I provide evidence of the bounding effects of segregation on social capital. While some scholars suggest residential homogeneity favours social capital, others argue that benefits occur within privileged neighbourhoods. The effects of segregation on social capital are less clear at lower scales and in highly unequal Global South cities. My argument is twofold. First, I uncover the dynamics of segregation below the neighbourhood scale. I use the notion of horizontal micro-segregation to identify the social and spatial conditions associated with a higher concentration of street-level segregating infrastructure. My methodological approach draws on data for all residential blocks in Lima, Peru (N = 99,685). I find that suburban-inspired urban design is positively associated with micro-segregating infrastructure, upon controlling for other factors such as socioeconomic status, density, and urbanization age of each block. Second, I provide evidence of the bounding effects of segregation on social capital. Using ten waves of the Lima Cómo Vamos survey (2010–2019), I show that micro-segregating infrastructure is associated with higher trust in neighbours and lower civic engagement. These findings indicate that exposure to segregation affects social capital within and across secluded neighbourhoods throughout the socioeconomic spectrum.
European Permanent Grasslands: A Systematic Review of Economic Drivers of Change, Including a Detailed Analysis of the Czech Republic, Spain, Sweden, and UK
Authors: Elliott John , Tindale Sophie , Outhwaite Samantha , Nicholson Fiona , Newell-Price Paul , Sari Novieta H. , Hunter Erik , Sánchez-Zamora Pedro , Jin Shan , Gallardo-Cobos Rosa , Miškolci Simona , Frewer Lynn J.
Published: January 2024

Permanent grasslands (PG) feature in the European rural landscape and represent a major agricultural production resource. They support multiple non-provisioning ecosystem services (ES), including climate regulation, flood control, biodiversity, and pollination. PG are at risk of loss or degradation due to agricultural land use and land management changes. The objective of this systematic review is to identify the main economic influences shaping management and maintenance of PG, and the risks and opportunities for delivery of a range of ES. A total of 51 papers were included. Relevant policy interventions and economic drivers are identified in relation to how they shape the management of EU grasslands over time and across farming systems, countries, or biogeographic zones. A high reliance on public payments from the EU Common Agricultural Policy (CAP), with uneven impact on mitigating PG losses and associated ES provisions, was identified, which needs to be considered in relation to ongoing CAP reform. There is a gap in the literature regarding economic tipping points for change. Future research needs to identify and map ES provisions by PG along with trade-offs and synergies, and link this to policy. There are substantive challenges to maintaining Europe’s PG area and management, which must be addressed through EU-wide instruments.