bluuebunny/crossref_metadata_2025 huggingface dataset:
IgG4 antibodies to the recombinant filarial antigen Wb-Bhp-1 decrease dramatically following treatment of lymphatic filariasis
Authors: Greene Sarah E. , Huang Yuefang , Curtis Kurt C. , King Christopher L. , Fischer Peter U. , Weil Gary J.
Published: June 2023

Background

Lymphatic filariasis (LF) is a neglected tropical disease and a major cause of chronic disability. Improved diagnostic tests are needed because of long-term persistence of anti-filarial antibodies or circulating filarial antigenemia after treatments that clear microfilaremia. Here, we assess changes in levels of antibodies to the recombinant filarial antigens Wb-Bhp-1, Wb123, and Bm14 after anti-filarial treatment.

Methodology/principal findings

IgG4 antibodies to recombinant filarial antigens were assessed by ELISA. We tested serial plasma samples from a clinical trial in Papua New Guinea. Before treatment, 90%, 71% and 99% of participants had antibodies to Wb-Bhp-1, Wb123, and Bm14, respectively. Antibodies to Wb-Bhp-1 and Wb123, but not Bm14, were significantly higher in participants with persistent microfilaremia 24 months after treatment. Antibodies to all three antigens declined significantly by 60 months after treatment with ivermectin, diethylcarbamazine and albendazole despite circulating filarial antigen in 76% of participants. By 60 months follow up, antibodies to Wb-Bhp-1, Wb123, and Bm14 were detected in 17%, 7% and 90% of participants, respectively. Antibodies to Wb-Bhp-1 also declined more rapidly after treatment than antibodies to Bm14 in samples from a clinical trial conducted in Sri Lanka. We also tested archived serum samples from people living in filariasis-endemic communities in Egypt with different infection profiles. Antibodies to Wb-Bhp-1 were detected in 73% of microfilaremic people, 53% of amicrofilaremic people with circulating filarial antigen, and 17.5% of endemic individuals without microfilaria or circulating filarial antigen. Tests performed with legacy samples from India showed that few people with filarial lymphedema had antibodies to these recombinant antigens.

Conclusions

Antibodies to Wb-Bhp-1 and Wb123 are more closely correlated with persistent microfilaremia than circulating filarial antigenemia or antibodies to Bm14, and they clear more rapidly after anti-filarial treatment. Additional studies are needed to assess the value of Wb-Bhp-1 serology as a tool for determining the success of LF elimination efforts.
An experimental assessment of detection dog ability to locate great crested newts (Triturus cristatus) at distance and through soil
Authors: Glover Nicola Jayne , Wilson Louise Elizabeth , Leedale Amy , Jehle Robert
Published: June 2023

Detection dogs are increasingly used to locate cryptic wildlife species, but their use for amphibians is still rather underexplored. In the present paper we focus on the great crested newt (Triturus cristatus), a European species which is experiencing high conservation concerns across its range, and assess the ability of a trained detection dog to locate individuals during their terrestrial phase. More specifically, we used a series of experiments to document whether a range of distances between target newts and the detection dog (odour channelled through pipes 68 mm in diameter) affects the localisation, and to assess the ability and efficiency of target newt detection in simulated subterranean refugia through 200 mm of two common soil types (clay and sandy soil, both with and without air vents to mimic mammal burrows, a common refuge used by T. cristatus). The detection dog accurately located all individual T. cristatus across the entire range of tested distances (0.25 m– 2.0 m). The substrate trials revealed that the detection dog could locate individuals also through soil. Contrary to existing studies with detection dogs in human forensic contexts, however, detection was generally slower for T. cristatus under sandy soil compared to clay soil, particularly when a vent was absent. Our study provides a general baseline for the use of detection dogs in locating T. cristatus and similar amphibian species during their terrestrial phase.
A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction
Authors: Pan Junwei , Liu Ming , Duan Xiaozong , Wang Dan
Published: June 2023

Long noncoding RNAs (lncRNAs) encompass short open reading frames (sORFs) that can be translated into small peptides. Here, we investigated the encoding potential of lncRNA LINC00665 in osteosarcoma (OS) cells. Bioinformatic analyses were utilized to predict the lncRNAs with encoding potential in human U2OS cells. Protein expression was assessed by an immunoblotting or immunofluorescence method. Cell viability was assessed by cell counting Kit-8 (CCK-8). Cell proliferation was detected by 5-ethynyl-2’-deoxyuridine (EdU) assay. Cell migration was gauged by transwell assay. The downstream effectors of the short peptide were verified using qualitative proteome analysis after immunoprecipitation (IP) experiments. The effect of the short peptide on protein interactions were confirmed by Co-Immunoprecipitation (CoIP) assays. We found that lncRNA LINC00665 encoded an 18-amino acid (aa)-long short peptide (named LINC00665_18aa). LINC00665_18aa suppressed the viability, proliferation, and migration of human MNNG-HOS and U2OS OS cells in vitro and diminished tumor growth in vivo. Mechanistically, LINC00665_18aa impaired the transcriptional activity, nuclear localization, and phosphorylation of cAMP response element-binding protein 1 (CREB1). Moreover, LINC00665_18aa weakened the interaction between CREB1 and ribosomal protein S6 kinase A3 (RPS6KA3, RSK2). Additionally, increased expression of CREB1 reversed the inhibitory effects of LINC00665_18aa on OS cell proliferation and migration. Our findings show that the short peptide LINC00665_18aa exerts a tumor-inhibitory function in OS, providing a new basis for cancer therapeutics through the functions of the short peptides encoded by lncRNAs.
Code Stroke Postendoscopy: A Case of Pneumocephalus From a Spinal-Esophageal Fistula
Authors: Fetz Andrew , Ghaseminejad Farhad , Kim Hyun Jae , Gan S. Ian
Published: June 2023

Esophageal fistula to the respiratory tract and mediastinum is a well-described complication from esophageal malignancies. Spinal-esophageal fistula (SEF) on the other hand is a much rarer complication that has only been reported in few instances. Here, we report a unique case of fatal spinal-esophageal fistula with an associated pneumocephalus in an 83-year-old woman with metastatic esophageal squamous cell carcinoma.
Miliary Tuberculosis in a Patient With Ulcerative Colitis Treated With Tofacitinib
Authors: Verma Shruti , Singh Arshdeep , Kakkar Chandan , Tripathi Ashish , Midha Vandana , Sood Ajit
Published: June 2023

Immunosuppression with tumor necrosis factor-alpha inhibitors and tofacitinib is a risk factor for reactivation of latent tuberculosis (TB) and the development of active TB. We report a case of miliary TB in a patient on treatment with tofacitinib for active ulcerative colitis. By week 4 of therapy, a clinical response was achieved. Subsequently, although being on treatment, the patient started having fever with night sweats and myalgias. The investigative workup revealed pulmonary miliary TB. Tofacitinib was withdrawn, and antitubercular therapy was initiated. The patient responded, both clinically and radiologically, to the antitubercular therapy. This case report highlights the importance of screening for latent TB in patients receiving tofacitinib.
Weight Loss Success With Repeat Intragastric Balloon Placement After Hyperinflation and Removal of the Index Balloon
Authors: Craig Michael A. , Kay Carl L. , Stilwell Kendra T. , Quiles John G.
Published: June 2023

Intragastric balloons are an increasingly common endoscopic alternative to bariatric surgery for the treatment of obesity. Hyperinflation is a rare complication that presents as acute-onset epigastric pain, nausea, vomiting, early satiety, abdominal distention or bloating, and rapid weight loss. Hyperinflation requires prompt diagnosis and removal of the balloon to prevent complications including gastric outlet obstruction or gastric perforation. We present a case of intragastric balloon hyperinflation with removal of the index device, followed by replacement with a second balloon, resulting in continued weight loss without further adverse events.
Inovasi Industri Daging Buatan dalam Perspektif Fiqh Syafi’i
Authors: Hasibuan Tarmiji Umar Sainaddin , Muslim Azis
Published: June 2023

Penelitian ini untuk mengetahui bagaimana manfaat daging buatan di dunia industri khususnya makanan dan bagaimana Islam menjawab serta menanggapi munculnya daging buatan sebagai penemuan yang menjadi alternatif baru dari para ilmuan. Penelitian ini menggunakan metode kualitatif deskriptif. Data dikumpulkan dari berbagai buku, jurnal, berita, web dan media sosial. Kesimpulan dari penelitian ini adalah daging buatan memiliki manfaat bagi manusia terutama dalam dunia industri untuk memenuhi pasokan daging konvensional dan Islam menyatakan daging buatan halal jika bersumber dari hewan yang dilakukan proses penyembelihan serta hewan yang dianjurkan oleh Al-Qur’an seperti ikan dan belalang, kemudian Islam juga menghalalkan daging buatan yang berbahan vegan (nabati) seperti kacang-kacangan dan jamur.
[This study talks about the Islamic view on the innovation of the artificial meat industry. The purpose of this study is to find out how the benefits of artificial meat in the industrial world, especially food and how Islam answers and responds to the emergence of artificial meat as a discovery that is a new alternative from scientists. This research uses descriptive qualitative method. Data is collected from various books, journals, news, web and social media. The conclusion of this study is that artificial meat has benefits for humans, especially in the industrial world to meet the supply of conventional meat and Islam states that artificial meat is halal if it comes from animals that are carried out by the slaughter process and animals recommended by the Qur'an such as fish and grasshoppers, then Islam also allows artificial meat made from vegan (pland- based) such as beans and mushrooms.]
Charlotte Puiseux – De chair et de fer. Vivre et lutter dans une société validiste
Authors: Escuriet Meddy
Published: June 2023

Recensé : Charlotte Puiseux, De chair et de fer. Vivre et lutter dans une société validiste, Paris, La Découverte, 2022, 160 p.
Investigation of the relationship between functional movement screening scores and hamstring muscle strength in professional football players
Authors: İbiş Serkan , Kurt Songül , Aka Hasan , Oszlánczi Adrienn
Published: June 2023

The aim of this study is to examine the relationship between hamstring (H) muscle strength (peak muscle strength, average muscle strength and bilateral muscle strength differences between both legs) and Functional Movement Screening (FMS) test scores of professional football players. 14 professional male football players (age: 21.50±2.47) voluntarily participated in the study. Functional movement patterns of football players FMS test with the t kit, H muscle strength was determined with the H Board device. Spearman correlation analysis was used to determine the relationship between participants' H muscle strength and FMS test scores. While it was determined that the FMS total score of the football players was above the critical limit of 14 points in determining the injury risk, no relationship was found between the FMS total scores and the H muscle strength (p>0.05). As a result, there was a significant correlation between the FMS subtests (deep squatting, obstacle stepping, single line lunge and active straight leg lifting) and total scores of professional football players and the peak muscle strength, mean muscle strength and bilateral muscle strength differences between both legs of the H muscle group. No relationship was found. In the estimation of injuries according to FMS test scores, it may be recommended to evaluate the hip, knee and ankle flexor and extensor muscle groups in addition to the H muscle group and look at the relationship between them.
Extended English summary is in the end of Full Text PDF (TURKISH) file.  
Özet
Bu çalışmanın amacı, profesyonel futbolcuların hamstring (H) kas kuvveti (zirve kas kuvveti, ortalama kas kuvveti ve her iki bacak arasındaki bilateral kas kuvvet farkları) ile Fonksiyonel Hareket Taraması (FHT) test skorları arasındaki ilişkinin incelenmesidir. Çalışmaya gönüllü 14 profesyonel erkek futbolcu (yaş: 21,50±2,47) katılmıştır. Futbolcuların fonksiyonel hareket kalıpları FHT test kiti ile, H kas kuvveti H Board cihazı ile belirlenmiştir. Katılımcıların H kas kuvveti ile FHT test skorları arasındaki ilişkiyi belirlemede Spearman korelasyon analizi kullanılmıştır. Futbolcuların FHT toplam skorunun yaralanma riskini belirlemede kritik sınır olan 14 puanın üstünde olduğu belirlenirken, FHT toplam skorları ile H kas kuvveti arasında ilişki tespit edilmemiştir (p>0,05). Sonuç olarak profesyonel futbolcuların FHT alt testleri (derin çömelme, engel adımlama, tek çizgide hamle ve aktif düz bacak kaldırma) ve toplam skorları ile H kas grubuna ait zirve kas kuvveti, ortalama kas kuvveti ve her iki bacak arasındaki bilateral kas kuvvet farkları arasında anlamlı bir ilişki olmadığı bulunmuştur. FHT test skorlarına göre yaralanmaların tahmin edilmesinde H kas grubuna ilaveten kalça, diz ve ayak bileği fleksör ve ekstensör kas gruplarının da değerlendirilerek arasındaki ilişkiye bakılması önerilebilir.
The Orbital Properties of Black Holes: Exploring the Relationship between Orbital Velocity and Distance
Authors: Siagian Ruben Cornelius , Alfaris Lulut , Muhammad Aldi Cahya , Nyuswantoro Ukta Indra , Rancak Gendewa Tunas
Published: June 2023

This research explores the concept of black holes in the physics of general relativity, including its formation and properties. The study focuses on the relationship between the orbital velocity and orbital distance of objects around a black hole, which is measured in units of the speed of light (c) and kiloparsecs (kpc), respectively. Using observational techniques, the study produces a plot showing the relationship between orbital velocity and orbital distance, which follows Kepler's law modified by the Newtonian theory of gravity and general relativity. The study also highlights the effective potential of particles in orbit around a black hole, which combines the effects of kinetic energy and gravitational potential. The effective potential shows the gravitational and relativistic properties of black holes, such as the photon orbit radius, ISCO, and the spin parameter. The resulting plot demonstrates the characteristics of the Milky Way black hole and how its spin parameter and Schwarzschild radius affect the orbital properties of surrounding particles. The study concludes that the closer the orbital distance is to the black hole, the more the orbital velocity increases, and particles with high spin parameters and small Schwarzschild radii are unlikely to escape the black hole's gravity.
Kontribusi Tarikan Perjalanan Kawasan Perdagangan Dan Jasa pada Jalan Menoreh Raya, Semarang
Authors: Andrika Adela Febe , Basuki Yudi
Published: June 2023

Due to the increasing of people’s needs for goods and service, it encourages the trip attraction of commercial land uses. Menoreh Raya Street is secondary arterial street which function as commercial land use. This commmercial land use conduce the trip attraction that contribute to traffic flows. Therefore, the calculation of trip attraction’s contribution is needed to anticipate the problem in future. The purpose of this study is to know the contribution of commercial land use’s trip attraction on one corridor and the contribution of commercial land use’s trip attraction per type. The methods that used in this study are calculate the trip attraction and the contribution of trip attraction. The results show that this commercial land use contributes 9,75% to traffic flows of Menoreh Raya Street on peak hour. The biggest contribution is attracted by variety store by 24,93%, high-turnover (sit-down) restaurants by 21,09%, and quality restaurant by 10,62%. Menoreh Raya Street’s function as connection between downtown and sub-urban makes the traffic flows are dominated by go home after work activity. Moreover, people tends to buy some daily needs and dinner on evening’s peak hour. This study could be used to know the contribution of traffic volume that attracted by commercial land use on secondary arterial street’s traffic flows that has same characteristic with Menoreh Raya Street. The contribution of trip attraction is useful to anticipate the commercial land use’s trip attraction that affect the increasing of street load and traffic jam.
Tingkat Keadilan Spasial dalam Fasilitas Kesehatan untuk Penanganan Covid-19 Di Provinsi Jawa Tengah
Authors: Reza Adheni , Sugiri Agung
Published: June 2023

Equity is an aspect that must be considered so that the impacts and objectives of development can provide benefits to the entire community. Equity cannot be separated from the spatial context, especially if it refers to the distribution, especially main public facilities that are widely used by the community, such as education and health facilities. Failure to create equity in the distribution of public facilities can create spatial disparities, an issue that if allowed to occur can lead to inequality of welfare and unsustainability. This problem has been increasingly exposed since the emergence of the COVID-19 pandemic, which spreads disproportionately and the greatest impact is suffered by people with social economic disadvantage and other vulnerable populations. The case of COVID-19 in Central Java Province is one of the worst in Indonesia and its distribution tends to be uneven which can be caused by the occurrence of spatial disparities in health facility services. This study identifies the level of spatial equity obtained from public perception which is then analyzed by scoring method using a Likert scale. Of the 4 indicators used to measure spatial equality, the indicator of ease of access to health facilities gets the highest score, followed by health facilities adequacy, quality of service, and the lowest is procedural/administrative ease. The results also show that the level of spatial equity in city tends to be higher than in regency.
Tingkat Efektivitas Promosi Balai Taman Nasional Karimunjawa Pada Ekowisata Bahari Hutan Mangrove Taman Nasional Karimunjawa
Authors: Rahmansyah Muhammad Fauzi , Mussadun Mussadun
Published: June 2023

Tourism promotion is an activity to introduce, disseminate information about a product that has been made (tourism) to the whole community or tourists that is convincing, inviting, influencing and directing. Karimunjawa National Park Association as the manager of the area has duties and functions, one of which is to carry out promotional and marketing activities for the conservation of natural resources and their ecosystems, but the level of effectiveness of the promotion is not maximized because there has been a decrease in the number of mangrove tracking tourists over the last 4 years, the accumulation of waste left over from activities. tourists on beach and mangrove tracking tours, and many tourists access promotions through non-government private platforms. This research is located in the Marine Ecotourism Area of the Mangrove Forest, Karimunjawa National Park, Jepara Regency. This study aims to determine how effective the promotional activities that have been carried out by the Karimunjawa National Park Association on mangrove tracking ecotourism are. The approach used is a quantitative descriptive approach and a combination of the Likert scale method and the EPIC Model with data collection through questionnaires, interviews, and field observations. The results of the study describe the mangrove tracking tourism promotion activities carried out by the Karimunjawa National Park Association through the form of "Community Relations" promotion which is the most effective form of promotion among other methods with an EPIC Rate score of 3.99. The results of this study can be used as a tourism manager as a material for consideration and discussion in implementing and planning the next promotional activities in order to control the number of tourist visits and provide educational facilities to the wider community.
Perkembangan Aktivitas Industri Dan Bangkitan Aktivitasnya Di Kecamatan Tegowanu, Kabupaten Grobogan
Authors: Sari Danik Nur Puspita , Mardiansjah Fadjar Hari
Published: June 2023

Urbanization process has also shifted urban activities from urban cores its peripheries. Industrial development peripheries become one of the activities that strengthened rural-urban linkages in the form of core-peripheries interactions. This phenomenon also occurs in Semarang Metropolitan area, small towns in its peripheries as the locations for industrial development, including in Tegowanu District, Grobogan Regency. The development of industrial activities in the area also leads to other activities generation. The results show that industrial development in Tegowanu District appeared since 2009 by the development of a garment factory, which is followed by other industries, located in Mangunsari and Gebangan Villages. The industrial development is in a rural village area and industrial development in Tegowanu District is 23.08% per year. However, the generation of other activities in Mangunsari Villages is still low, although most of industrial activities’ development are located there. Tegowanu Kulon as an old urban village is the place where the most of other activities’ generated take place because industrial activities in Tegowanu District are still relatively new and developing, soo the impacts in generating other urban activities is still limited. However, the development of industrial activities in the area has resulted in more varied livelihoods and employment opportunities
Prawdziwe oblicze relatywizmu moralnego
Authors: Nyszko Artur
Published: June 2023

Peter Kreeft. 2021. Krytyka relatywizmu moralnego. Wywiad z pewnym absolutystą. Warszawa: Wydawnictwo „Fundacja Prodoteo”.
Godność dziecka i jego rodziców w nauczaniu Papieskiej Rady ds. Rodziny
Authors: Brzeziński Mirosław
Published: June 2023

Celem niniejszego artykułu jest przedstawienie najważniejszych elementów nauczania Papieskiej Rady ds. Rodziny dotyczących godności dziecka i jego rodziców w kontekście dzisiejszych zjawisk i przemian społecznych oraz aktualności tego nauczania. W tym celu posłużono się metodą analizy dokumentów tejże Rady oraz nauczania papieskiego w tym zakresie. Wskazano na nierozerwalny związek godności dziecka i jego rodziców z poszanowaniem praw regulujących płodność oraz z godnością aktu małżeńskiego. Wykazano również, że mentalność antykoncepcyjna i hedonistyczna zagraża zarówno godności dziecka, jak i jego rodziców. Wskazano też na konieczność uwrażliwienia świata nauki na ochronę godności osobowej każdego człowieka i dotarcie z tym przesłaniem do każdego człowieka oraz próbę wpływu na zmianę mentalności. Z nauczania Papieskiej Rady ds. Rodziny wynika też, na co wskazano w artykule, konieczność podmiotowego, a nie przedmiotowego traktowania każdej osoby, w tym jej wymiaru seksualnego i płciowego.
Neopterin and kynurenine in serum and urine as prognostic biomarkers in hospitalized patients with delta and omicron variant SARS-CoV-2 infection
Authors: Krčmová Lenka Kujovská , Matoušová Kateřina , Javorská Lenka , Šmahel Petr , Skála Mikuláš , Koblížek Vladimír , Škop Jan , Turoňová Dorota , Gančarčíková Markéta , Melichar Bohuslav
Published: June 2023

Objectives

Currently, no biomarker or scoring system could clearly identify patients at risk of progression to a severe coronavirus disease (COVID)-19. Even in patients with known risk factors, the fulminant course cannot be predicted with certainty. Analysis of commonly determined clinical parameters (frailty score, age, or body mass index) together with routine biomarkers of host response (C-reactive protein and viral nucleocapsid protein) in combination with new biomarkers neopterin, kynurenine, and tryptophan, could aid in predicting the patient outcome.

Methods

In 2021 and 2022, urine and serum samples were prospectively collected on 1st to 4th day after hospital admission in 108 consecutive COVID-19 patients hospitalized at the University Hospital Hradec Králové, Czech Republic. Delta and omicron virus variants were studied. Neopterin, kynurenine and tryptophan were determined by liquid chromatography.

Results

A significant correlation was observed between urinary and serum biomarker concentrations. Urinary and serum neopterin, kynurenine and kynurenine/tryptophan ratio were significantly (p≤0.05) higher in patients who subsequently needed oxygen therapy vs. patients without oxygen therapy. These parameters were also significantly increased in patients who died during the hospitalization compared to survivors. Complex equations have been derived using the investigated biomarkers and other clinical or laboratory parameters to predict the risk of subsequent oxygen therapy or death during hospitalization.

Conclusions

Present data demonstrate that neopterin, kynurenine and kynurenine/tryptophan ratio in the serum or in the urine represent promising biomarkers in the management of COVID-19 that may help to guide important therapeutic decisions.
Does the Free Group Agency Account of Legitimacy Require Democracy?
Authors: Bech-Pedersen Palle , Haberkost Finn
Published: June 2023

In this critical comment, we argue that nondemocratic, but decent regimes fail to constitute legitimate governance under Applbaum’s free group agency account. To make this case, we first introduce the three principles of liberty, equality and agency that Applbaum takes to flow directly from his free agency conception of legitimacy. Against this backdrop, we discuss Applbaum’s claim that a nondemocratic regime along the lines of a Rawlsian decent consultation hierarchy could meet the threshold of legitimacy. Contrary to this suggestion, we argue that nondemocratic, but decent regimes cannot claim legitimacy under Applbaum’s account because they are constitutively inegalitarian, thus failing to adequately grant citizens the equal normative power without which legitimacy is unattainable under the free group agency account.
Archaeology and Border Studies: broadening the dialogue
Authors: Gardner Andrew
Published: June 2023

Hanscam and Buchanan (2023) have written a timely and important contribution to the evolving discussion about the politicisation of archaeology, and the prominent role that intersections with Border Studies might play in future debates. I concur with many of their substantive points. Focusing on boundaries and bordering processes is a natural extension of the work on identities that has been a dominant theme in archaeology since at least the 1990s; it also provides a counterbalance to recent trends that seek to extend globalisation deeper into the past, not least in Roman studies (e.g. Pitts & Versluys 2014). As Hanscam and Buchanan note for the public sphere, there are also numerous academic contributions within the Border Studies literature that draw upon archaeological or historical examples, though often framed within outdated understandings of the meanings of these boundaries (e.g. Nail 2016; see Gardner 2022). Our role in engaging with these contributions is not simply to point out mistakes, but also to learn from this range of perspectives on the significance of boundaries in human societies, to fuse them with our own interpretations of ancient borderlands, and to contribute to contemporary debates that crystallise many of the most important issues of our times.
Trends in the production of olive oil amphorae at ceramic workshops in Roman Baetica: a chrono-proportional representation method
Authors: González Tobar Iván
Published: June 2023

During the first few centuries AD, Rome and the imperial frontiers were supplied with olive oil from the province of Hispania Baetica (southern Spain). Vast quantities of oil were exported in Dressel 20 amphorae. But how did the agricultural economy of Baetica relate to global demand and how did it change over time? The author focuses on relative changes in agricultural output, using a new method to model fluctuations in amphora production based on more than 1000 waster sherds collected from 23 amphora workshops in the Guadalquivir Valley. The chrono-proportional representation method indicates variation in production between individual workshops and wider production districts, contributing to assessments of the scale and organisation of the Roman economy.
Maverick Movies: New Line Cinema and the Transformation of American Film
Authors: Herbert Daniel
Published: June 2023

Maverick Movies tells the improbable story of New Line Cinema, a company that cut a remarkable path through the American film industry and movie culture. Founded in 1967 as an art film distributor, New Line made a small fortune running John Waters’s Pink Flamingos at midnight screenings in the 1970s and found reliable returns with the Nightmare on Elm Street franchise in the 1980s. By 2001, the company competed with the major Hollywood studios and reached global box office success with the Lord of the Rings franchise. Blurring boundaries between high and low culture, between independent film and Hollywood, and between the margins and the mainstream, New Line Cinema epitomizes Hollywood’s shift in focus from the mass audience fostered by the classic studios to the multitude of niche audiences sought today.
Arms race between anti‐silencing and RdDM in noncoding regions of transposable elements
Authors: Sasaki Taku , Kato Kae , Hosaka Aoi , Fu Yu , Toyoda Atsushi , Fujiyama Asao , Tarutani Yoshiaki , Kakutani Tetsuji
Published: June 2023

Transposable elements (TEs) are among the most dynamic parts of genomes. Since TEs are potentially deleterious, eukaryotes silence them through epigenetic mechanisms such as repressive histone modifications and DNA methylation. We previously reported that Arabidopsis TEs, called VANDALs, counteract epigenetic silencing through a group of sequence‐specific anti‐silencing proteins, VANCs. VANC proteins bind to noncoding regions of specific VANDAL copies and induce loss of silent chromatin marks. The VANC‐target regions form tandem repeats, which diverge rapidly. Sequence‐specific anti‐silencing allows these TEs to proliferate with minimum host damage. Here, we show that RNA‐directed DNA methylation (RdDM) efficiently targets noncoding regions of VANDAL TEs to silence them de novo. Thus, escape from RdDM could be a primary event leading to the rapid evolution and diversification of sequence‐specific anti‐silencing systems. We propose that this selfish behavior of TEs paradoxically could make them diverse and less harmful to the host.
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway
Authors: Cheng Yalan , Zhang Zhentong , Gao Peidong , Lai Hejin , Zhong Wuling , Feng Ning , Yang Yale , Yu Huimin , Zhang Yali , Han Yumo , Dong Jieya , He Zhishui , Huang Rui , Zhai Qiwei
Published: June 2023

Obesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the underlying mechanisms are yet to be elucidated. Adeno‐associated virus (AAV) frequently infects humans and has been widely used in gene therapy, but the risk of AAV infection such as HCC should be further evaluated. Here, we show that recombinant AAV injection caused liver injury, hepatic necroptosis, and HCC in db/db or high‐fat diet‐induced hyperglycemic and obese mice, but not in mice with only hyperglycemia or obesity. Prednisone administration or knockdown of Pebp1, highly expressed in db/db mice, alleviated hepatic injury and necroptosis induced by recombinant AAV in mice with diabetes and obesity. Inhibition of Pebp1 pathway also attenuated inflammation and necroptosis in vitro. Our findings show that AAV infection is a critical risk factor for HCC in patients with diabetes and obesity, and AAV gene therapy for these patients should be carefully evaluated. Both prednisone treatment and targeting Pebp1 pathway are promising strategies to alleviate inflammation and necroptosis that occurred in AAV gene therapy or related diseases.
Echocardiographic features of myocardial rupture after acute myocardial infarction on emergency echocardiography
Authors: Lee Byung Wook , Cha Yong Sung , Hwang Sung Oh , Kim Yoon-Seop , Kim Sun Ju
Published: June 2023

Objective Myocardial rupture is a fatal complication of acute myocardial infarction (AMI). Early diagnosis of myocardial rupture is feasible when emergency physicians (EPs) perform emergency transthoracic echocardiography (TTE). The purpose of this study was to report the echocardiographic features of myocardial rupture on emergency TTE performed by EPs in the emergency department (ED).Methods This was a retrospective and observational study involving consecutive adult patients presenting with AMI who underwent TTE performed by EPs in the ED of a single academic medical center from March 2008 to December 2019.Results Fifteen patients with myocardial rupture, including eight (53.3%) with free wall rupture (FWR), five (33.3%) with ventricular septal rupture (VSR), and two (13.3%) with FWR and VSR, were identified. Fourteen of the 15 patients (93.3%) were diagnosed on TTE performed by EPs. Diagnostic echocardiographic features were found in 100% of the patients with myocardial rupture, including pericardial effusion for FWR and a visible shunt on the interventricular septum for VSR. Additional echocardiographic features indicating myocardial rupture were thinning or aneurysmal dilatation in 10 patients (66.7%), undermined myocardium in six patients (40.0%), abnormal regional motions in six patients (40.0%), and pericardial hematoma in six patients (40.0%).Conclusion Early diagnosis of myocardial rupture after AMI is possible using echocardiographic features on emergency TTE performed by EPs.
Interference, explicitation, implicitation and normalization in third code Spanish: Evidence from discourse markers
Authors: Rabadán Rosa , Gutiérrez-Lanza Camino
Published: June 2023

Third code research has documented the distinctiveness of translated language and singled out recurrent tendencies framing them as translation universals. This paper aims to identify the interaction between interference, explicitation, implicitation and normalization and their potential relationship(s) with other variables, such as register. The focus of the study is on Spanish discourse markers (DMs) translated from English. This study uses interference, explicitation, implicitation and normalization as methodological tools to unveil these patterns. Evidence comes from a bilingual parallel corpus (P-ACTRES 2.0), a corpus of translated Spanish (CETRI), and a reference corpus of contemporary Spanish (CORPES XXI). We select the input DMs according to two criteria: first, we focus on DMs showing cross-linguistic formal correspondence, indicating the possibility of grammatical interference; second, we consider different procedural meanings for the DMs to anticipate potential regularity distortions. Results indicate that DM underuse in the target texts generally co-occurs with explicitation. Register is an important variable: implicitation is more frequent in non-fiction and, together with normalization, affects the majority of DMs. Evidence also points to the DMs' semantics influencing implicitation and explicitation.
Tiga Ajaran Hindu dalam Menumbuhkan Sikap Toleransi Antar Umat Beragama
Authors: Agustina Dena
Published: June 2023

The purpose of this study is to discuss the three Hindu teachings in fostering an attitude of tolerance between religious communities. This research method uses qualitative research through literature study and content analysis. The results and discussion of this research are Hinduism and its development, the concept of tolerance in general, and Hindu religious teachings related to tolerance in religion. The conclusion of this study is that Indonesia is a plural country. This plurality can be seen from aspects of culture, language, race, ethnicity, and one of them is religion. Religious differences are often very sensitive differences for adherents. Conflicts between religions are not uncommon in Indonesia. So to overcome and prevent conflicts between religious communities, it is necessary to instill the values of tolerance in every human being. Tolerance itself is an attitude of mutual respect, letting, and respecting what is different from him. In every religion, of course, it is taught about the value of tolerance and mutual respect between religious people. One of them is in Hinduism, in Hinduism there are three teaching concepts that discuss the attitude of tolerance between humans, namely Vasudhaiva Kutumbhakam, Tat Twam Asi, and Tri Hita Karana.
“Cults,” Coercion, and Control
Authors: Sessions Erin Martine , Doherty Bernard
Published: June 2023

In the face of what has been called an epidemic of domestic and family violence (DFV) in several countries, scholarly analysts, journalists, and policymakers have increasingly turned to the matrix of ideas around what Evan Stark has called coercive control, for insights into the dynamics of abusive relationships. In seeking to address this social problem, some commentators—in both the DFV research space and cultic studies— have begun to see a link between New Religions (“cults”) and coercive control, and use the language of coercive control to revive a problematic rhetoric linked to ideas about so-called “brainwashing.” This article highlights some of the commonalities between coercive control, as theorized by Stark and others, and the classic work on coercive persuasion as this was applied—sometimes disingenuously—to a wave of New Religions during the 1970s through to the 1990s. Secondly, this article analyses the rhetorical use of elements of the “cult stereotype” in contemporary popular and academic discussions of DFV and how the language of coercive control has been employed. We conclude that the use of coercive control language in cultic studies is largely superficial and engages in tactical ambiguities which seek to apply various “cultic brainwashing” ideas in a new context and suggest that this approach is unhelpful both to victim-survivors of DFV and those who have experienced abuse in particular New Religions or, indeed, within mainstream religion.
Thea Riofrancos, Resource Radicals: From Petro-Nationalism to Post-Extractivism in Ecuador
Authors: Swanson Tod Dillon
Published: June 2023

Thea Riofrancos, Resource Radicals: From Petro-Nationalism to Post-Extractivism in Ecuador. (Durham: Duke University Press 2020) xi + 252 pp., $26.95 (pbk), ISBN: 9781478008484.
After the Flight
Authors: Montana Katherine
Published: June 2023

Following the deposition of Mary, Queen of Scots in 1567, she fled first to Lochleven and, following defeat by supporters of James VI, she fled south to England seeking refuge. In England, Queen Elizabeth I allowed for conferences at York and Westminster to consider Mary's involvement in the murder of her husband Henry Darnley. This article explores the contemporary legality of such conferences, and whether they might be regarded as trials.
CONCEPÇÕES DOCENTES NORTEADORAS DE PRÁTICAS PEDAGÓGICAS COM BEBÊS EM CRECHE
Authors: Cruz Rosimeire , Carneiro Maria Crélia
Published: June 2023

Este artigo tem como mote central o currículo para bebês no espaço coletivo da creche, tomando como foco as concepções docentes acerca de bebês, creche, currículo e professora de bebês. Resulta de uma pesquisa qualitativa mais ampla com características de um estudo de caso, que analisou o currículo em desenvolvimento em turmas de berçário sob a responsabilidade de duas docentes em uma instituição pública municipal. Os principais instrumentos de geração de dados foram observações e entrevistas. Seus aportes teóricos fundamentais foram os estudos de pesquisadores que: explicitam e diferenciam os conceitos de criança, infância e bebês, notadamente, oriundos da Sociologia da Infância e da Psicologia do desenvolvimento; consideram o currículo como instrumento que contempla a integralidade da criança; que a respeita e a enfatiza; e inclui as práticas sociais cotidianas (BARBOSA, 2010; GOBBATO; BARBOSA, 2017; BARBOSA; RICHTER, 2009). Seus resultados evidenciaram práticas docentes marcadas por concepções bastante sedimentadas, originadas, provavelmente, de vivências pessoais e do senso comum. Assim, tratam-se de fazeres pedagógicos assentados na compreensão de bebês como pouco competentes e sem agência; de creche como lugar exclusivo de “guarda”; de currículo como instrumento desnecessário às turmas de berçário; e de professora que atua nesses agrupamentos como alguém que precisa gostar de crianças e possuir saberes “naturais” da maternidade. Considerando a relação entre formação docente e qualidade das oportunidades de aprendizagem e desenvolvimento criadas para e com as crianças nas creches, constata-se a necessidade de formação inicial e continuada específica para pedagogos que pretendem exercer a docência com bebês.
Hermann Hesse’nin “Çarklar Arasında” Adlı Romanında Çocuk Benlik ve Varoluşçu İmgeler
Authors: KIZILHAN Pınar
Published: June 2023

Hermann Hesse’nin “Çarklar Arasında” adlı yapıtında, vaktinden önce olgunlaşması beklenilen çocukluğun, gerçek dışı ikinci bir çocukluk dönemi yaşamaya başlayacağı tehlikesini doğuran zaman aşımına uğramış bir eğitim sisteminin eleştirisi yapılır. Çocukluktan yoksun bırakılan ruhun içe dönük saldırganlığı, giderek kendine yönelmeye başlar. Eserde, eğitim otoriteleri ve aileler tarafından çocukların benliklerinden uzaklaştırılarak katı ve disiplin yanlısı bir eğitim sistemi yoluyla, çocuklara benimsetilen “üstün başarı idealinin” çocuk benliğin örselenmesine ve bunun telafisi olmayan sonuçlarına değinilmektedir. Yapıtta, Almanya’nın Schwaben kasabasındaki Maulbronn Manastır okulunda, çocukların maruz kaldığı olumsuz eğitsel ilişkiler ele alınmaktadır. Bu okulu, aile ve kasaba çevresinin baskısıyla, ikincilikle kazanan ancak sonrasında kendisine hiç bir gelişme fırsatı vermediğini gören Hans Giebenrath'ın psişik ruh karışıklığı, onu hem doğaya meftun alışkanlıklarından hem de başarı idealinden uzaklaştırır. Kasabaya dönerek, “demir çarkları eğeleyen çırak” olarak yaşamına devam eder. El becerisiyle yaptığı iş ise onu mutlu etmez. Irmağa düşer, gizemli ölümü tüm kasabayı üzer. Hesse’nin; eğitbilimsel açıdan açık ve örtük eğitim programlarının birbiriyle çelişen unsurlarının dikkati çektiği, bu yapıtının, çocuk benliğe özgü değerlerin analizi ve varoluşçu imgeler açısından ele alınmasının önem taşıdığı düşünülmektedir. Bu araştırmanın amacı, Hermann Hesse’nin “Çarklar Arasında” adlı yapıtında, çocuk benliğin varoluşçu imgelerini çözümlemektir. Yapıt, anlatı analizi tekniğiyle çözümlenmiştir. Elde edilen bulgulardan iki temaya ulaşılmıştır: Birinci tema olan “Çocuk Benlik” altında; “benlik özerkliği,” “yönlendirilmemiş düşünme,” “özgür istenç” adlı kategoriler belirlenmiştir. İkinci tema olan, “Varoluşçu İmgeler” altında; “doğa,” “arkadaşlık” ve “çelişkiler” adlı kategoriler elde edilmiştir. Araştırma sonuçları, açık ve örtük eğitim programlarının çocukların ilgi ve yetenekleri doğrultusunda yaşayarak yaparak öğrenmelerine fırsat sunması, kararlarında ve eylemlerinde özerk birey olmalarını desteklemesi gerektiğini ortaya koymaktadır. Çocukların çevresindeki yetişkinlerin de çocuklarla dengeli ve sağlıklı bir iletişim kurması için çocuk benlik ve yetişkin benliğin bir arada yaşaması, çocuk benliğin üst evrelere sağlıklı evrilmesi için çocukların doğayla geçirdikleri yaşantının önemini göstermektedir
VIBRATION AND HEAT TRANSFER STUDY ON IMPROVED ELASTIC BUNDLE HEAT EXCHANGER
Authors: Wang Xiaoyan , Ji Jiadong , Zhang Jingwei
Published: June 2023

The comprehensive performance of an improved elastic tube bundle heat exchanger (IETB) was studied by varying its structural parameters (diameter and wall thickness). The influence of the structural parameters on the vibration and heat transfer properties of IETBs at different inlet velocities (uin) was studied. The results show that the average amplitude of IETBs maximum increase was 41.67% and the average heat transfer coefficient (HTC) maximum increase was 46.47% as the uin value increased from 0.3 m/s to 0.5 m/s. As the diameter increased from 8 mm to 12 mm and the wall thickness increased from 1.2 mm to 1.8 mm, the average amplitude of IETBs maximum decreased by 98.18% and 11.73%, respectively, and the heat transfer intensity of vibration enhancement decreased by 10.69% and 15.83%, respectively. According to the performance evaluation criteria analysis, when the wall thickness was constant at 1.5 mm, the comprehensive performance of the IETB heat exchanger with a diameter of 8 mm was better than that at other diameters. When the diameter was constant at 10 mm, the IETB heat exchanger with a wall thickness of 1.2 mm had a better comprehensive performance than those with other wall thicknesses.
Feminist Aktivizmin Sesinin Duyurulması Sürecinde Yeni Medya: Olanaklar ve Engellere Dair Uzman Görüşleri Üzerinden Bir Değerlendirme
Authors: ARSLAN Fatmanur , GÜL ÜNLÜ Derya
Published: June 2023

Kadınları bilgilendirmek amacıyla e-posta listeleri, web siteleri ve forumlarla başlayan aktivist pratikler, her kullanıcının kendi söylemini üretmesini mümkün kılan sosyal medya platformlarının ortaya çıkışıyla hız kazanmış, çeşitlenmiştir. Ancak yeni medya ortamlarındaki aktivist pratikler, erişim ve kullanım becerileri bakımından farklar/bölünmeler, kullanıcı ve platform mekanizması kaynaklı tehditlerle de karşı karşıyadır. Bu bakımdan, yeni medyanın feminist aktivizme sunduğu olanakları ve engelleri belirlemek, feminist aktivistlerin seslerini nasıl daha gür bir şekilde duyurabileceklerinin anlaşılması için önemlidir. Bu odak noktasından hareketle gerçekleştirilen çalışma, uzman görüşlerinden yola çıkılarak, Türkiye’deki dijital feminist aktivizmin mevcut durumunun tanımlanıp, yeni medyanın feminist aktivizm için sunduğu olanak ve engellerin tespit edilmesi ve engellerin nasıl azaltılabileceği, olanakların nasıl arttırılabileceğine dair bir yol haritasının çizilmesi amacını taşımaktadır. Bu amaç doğrultusunda, konuda uzman 26 katılımcı ile yarı yapılandırılmış görüşmeler gerçekleştirilmiştir. Araştırma sonucunda, dijital ortamın yapısal özellikler ve kullanıcı kaynaklı içerik nedeniyle çeşitli engeller barındırmakla birlikte, geniş bir yelpazede feminist pratiklere katılımı olanaklı kıldığı tespit edilmiştir.
Fibonacci Level Adjustment for Optimizing Player’s Performance and Engagement
Authors: Masyfa Faiz Hilmawan , Tolle Herman , Tibyani Tibyani , Hartono Pitoyo
Published: June 2023

Players’ engagement intensity in computer games is influenced by the level of difficulty the game offers. Traditional game-level plots adopt linear increases that sometimes do not match the users’ skill growth, causing boredom and hampering the users’ further skill growth. In this study, a nonlinear level adjustment scenario was proposed based on the Fibonacci sequence that provides gradual increases in the early stages of the games but more drastic changes in later phases. Here, the game’s difficulty level was automatically decided by a machine learning method. To test the proposed method, comparisons between four level adjustments in computer games: traditional plots, self-selected plots, linear adaptive plots, and the proposed nonlinear adaptive plots were run. The experiment was carried out with 40 testers. The experiment results show that the best player’s peak level in the proposed nonlinear adjustment was twice as high as that of linear adjustment. Also, the number of stages required to reach the peak under the proposed scenario was half that of linear games. This high playing performance goes hand in hand with deep playing engagement. The results demonstrate the efficiency of the proposed level adjustment algorithm.