bluuebunny/crossref_metadata_2025 huggingface dataset:
Peri-Ampullary Tumour; An Unusual Cause of Upper Gastrointestinal Bleeding
Authors: AS Maiyaki , NA Dankiri , MB Bello , AU Ibrahim , H Umar , IM Wasagu , HE Mohammed , AJ Bamaiyi , SM Sahabi , M Abdullahi , K Ekochin , F Emetumah
Published: September 2024

Periampullary tumors are cancers that arise in the region of the around the ampulla of Vater, where the bile duct and pancreatic duct converge and empty into the small intestine. This region is very critical for digestive enzyme and bile secretions. This may be associated with slow disease progression, age related changes delayed onset of symptoms and lack of screening and diagnostic facilities. These tumours can be challenging to diagnose and manage due to their proximity to several vital structures. Upper gastrointestinal bleeding may be a rare clinical presentation following tumoral ulceration, erosion into blood vessels or nearby structures or secondary complications like pancreatitis or portal hypertension. Identifying the anatomical origin of these malignancies is usually a herculean task. This will require prompt oesophagogastroduodenoscopy and imaging to determine the source and appropriate management. This is especially true given the region's transitional character, closeness to various structures, and overlapping features among them. We present periampullary tumour an unusual cause of upper gastrointestinal bleeding in a resource limited setting. A52 year old Nigerian male was admitted at the Usmanu Danfodiyo University Teaching Hospital, Sokoto for evaluation following a 3 months history of progressive weight loss, generalized body weakness and a burning and occasionally colicky, persistent, non-radiating epigastric pain, loss of appetite, easy fatiguability, occasional dizziness and recurrent non-projectile post-prandial non-billous vomiting. Though he had no hematemesis, he had history of passage of malaena. The patient was fully conscious on admission, pale, wasted with a markedly tender epigstric region. He was tachycardic with a minimal elevation in blood pressure level of 138/94mmHg. He had an international normalized ratio (INR) of 1.0. Oesophagogastroduodenoscopy was performed which showed a polypoid fungating mass at the1st extending to the 2nd part of the duodenum. A Computerized Tomogram scan of the abdomen showed a diffuse circumferential duodenal wall thickening of 1st and 2nd parts (more in 2nd part) with reduction in luminal calibre of duodenum and mildly dilated pancreatic, common bile, common hepatic ducts. Multiple biopsies were taken for histology which showed moderately differentiated aadenocarcinoma. Surface epithelium composed of columnar epithelial cells which can be seen in the top right of the image below with an invasive tumour, seen infiltrating the lamina propria in the lower left. He went on to have an exploratory laparotomy with triple bypass involving a side to side gastrojejunal anastomosis and cholecystojejunostomy and entero-enterotomy folowing which he went on to receive chemotherapy. As of the time of this write up the patient has recuperated well following his treatment.
Thoracic ultrasound: a review of the state-of-the-art
Authors: de Figueiredo Braga Colares1,2 Philippe , Thomaz Mafort3 Thiago , Marquesini Sanches1 Felipe , Braga Monnerat3 Laura , Metidieri Menegozzo4 Carlos Augusto , Wasum Mariani5 Alessandro
Published: September 2024

Thoracic ultrasound (TUS) is a tool that has become increasingly essential in the daily practice of thoracic medicine. Driven by the need to assess patients during the COVID-19 pandemic, there has been an increase in the use of point-of-care TUS, which has demonstrated several benefits, either as a complement to clinical decision-making for diagnosis or as a real-time guide for procedures, whether as a predictor or measure of treatment response. Here, we present a review of TUS, based on the most recent scientific evidence, from equipment and techniques to the fundamentals of pulmonary ultrasound, describing normal and pathological findings, as well as focusing on the management of lung disease and guidance for invasive thoracic procedures at the bedside. Finally, we highlight areas of perspective and potential lines of research to maintain interest in this valuable tool, in order to improve the diagnostic process and expand the treatment arsenal.
Thymidine-dependent Staphylococcus aureus and lung function in patients with cystic fibrosis: a 10-year retrospective case-control study
Authors: de Oliveira Tomaz1,2 Ana Paula , Camargo de Souza1 Dilair , Lucia Cogo1 Laura , Kasuko Palmeiro2,3 Jussara , da Silva Nogueira1,4 Keite , Rasmussen Petterle5 Ricardo , Antonio Riedi6 Carlos , Augusto Rosario Filho6 Nelson , Maria Dalla-Costa2 Libera
Published: September 2024

Objective: Thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus are being isolated with increasing frequency from patients with cystic fibrosis (CF). The aim of this study was to evaluate the relationship between TD-SCV isolation and pulmonary function in patients with CF, as well as to determine whether the emergence of TD-SCVs was associated with trimethoprim-sulfamethoxazole (TMP-SMX) use and with coinfection with other microorganisms. Methods: This was a retrospective case-control study including patients with CF who visited the Clinical Hospital Complex of the Federal University of Paraná, in Curitiba, Brazil, between 2013 and 2022. Demographic, clinical, and spirometric data, as well as information on TD-SCVs and other isolated microorganisms, were collected from the medical records of patients with CF and TD-SCVs (TD-SCV group; n = 32) and compared with those of a matched group of patients with CF without TD-SCVs (control group; n = 64). Results: Isolation of TD-SCVs was positively associated with TMP-SMX use (p = 0.009), hospitalization (p < 0.001), and impaired pulmonary function (p = 0.04). Conclusions: The use of TMP-SMX seems to contribute to the emergence of TD-SCVs, the isolation of which was directly associated with worse pulmonary function in our sample.
EVOLUÇÃO DA CIRURGIA GINECOLÓGICA: COMPARAÇÃO ENTRE TÉCNICAS CONVENCIONAIS E MINIMAMENTE INVASIVAS
Authors: Araújo Luana Sula Sousa dos Reis , Dazzi Aline Reinert , Caniato Felipe Meneguetti Caniato , Bailo Davit Willian , Triches Pedro Marlo , Seidl Isabele , Mazzardo Vanessa
Published: September 2024

A evolução da cirurgia ginecológica ao longo das últimas décadas reflete um avanço significativo na medicina, com a transição das técnicas convencionais para abordagens minimamente invasivas (TMIs), como a laparoscopia e a cirurgia robótica. Este artigo de revisão integrativa analisa criticamente essa evolução, comparando as técnicas tradicionais, que envolvem incisões maiores e maior morbidade, com as TMIs, que oferecem vantagens substanciais, incluindo menor trauma cirúrgico, recuperação acelerada, e redução de complicações pós-operatórias. A análise detalhada das intervenções cirúrgicas mais comuns na ginecologia, como histerectomia, miomectomia e tratamento da endometriose, evidencia a superioridade das TMIs em diversos aspectos, embora reconheça suas limitações, como a curva de aprendizado acentuada e os custos elevados.  Com o desenvolvimento de técnicas minimamente invasivas, observou-se uma mudança para abordagens menos traumáticas, proporcionando menor dor pós-operatória, menores complicações e uma recuperação mais rápida. A laparoscopia, introduzida nas décadas de 1960 e 1970, e a cirurgia robótica, popularizada nos anos 2000, revolucionaram a prática ginecológica ao oferecer maior precisão e menos invasividade. Apesar das vantagens, essas técnicas enfrentam desafios como a curva de aprendizado e altos custos, especialmente em centros com menos recursos. Assim, conclui-se que a cirurgia ginecológica está em uma trajetória de transformação contínua, com as TMIs estabelecendo novos padrões de cuidado que priorizam a segurança, eficácia e recuperação das pacientes, ao mesmo tempo em que se preparam para integrar futuras inovações que potencialmente melhorarão ainda mais os desfechos clínicos.
The Impact of Augmented Reality (AR) on User Engagement in Automotive Mobile Applications
Authors: Jaswanth Alahari  , Amit Mangal  , Swetha Singiri  , Om Goel  , Prof.(Dr.) Punit Goel
Published: September 2024

The digital and automotive application ecosystems have been rapidly transformed by augmented reality (AR). Mobile app augmentation in the automotive sector has shown a lot of potential in terms of improving user engagement and the overall experience. Exploring the impact of augmented reality on user engagement, advantages, problems, and future possibilities in automotive mobile apps is the focus of this research.
With the use of augmented reality (AR) technology integrated into automobile smartphone applications, users may enjoy real-time experiences, navigational assistance, and virtual vehicle customisation. The most essential benefit of all of these additions is the improvement they bring to user engagement and happiness. By superimposing digital information over the user's actual surroundings, the technology creates an immersive and natural experience.
It has also covered the difficulties of implementing automotive applications, such as the high cost of developing robust technology and concerns about user privacy. On the other hand, with the advent of new affordances, the future seems bright for the widespread use of augmented reality technology. Because of this, augmented reality (AR) for automotive mobile apps has a promising future in terms of innovation and integration across different parts of the user experience.
That is why augmented reality (AR) in car applications greatly improves the quality of life for the user. Its real-time interaction features cater to users' wants and preferences, greatly improving the overall user experience. As augmented reality develops further, it will play an increasingly important role in the car sector, opening up a wide range of possibilities for consumer engagement and happiness.
Optimizing Cloud-Based Clinical Platforms Best Practices for HIPAA and HITRUST Compliance
Authors: Vishwasrao Salunkhe  , Dheerender Thakur,  , Er.Kodamasimham Krishna  , Om Goel  , Prof.(Dr.) Arpit Jain
Published: September 2024

It is essential to ensure compliance with regulatory standards such as HIPAA (Health Insurance Portability and Accountability Act) and HITRUST (Health Information Trust Alliance) in order to safeguard patient information and preserve trust. This is because cloud-based clinical platforms are becoming increasingly popular among healthcare organisations. The purpose of this paper is to give a complete review of best practices for optimising cloud-based healthcare platforms, with a particular emphasis on HIPAA and HITRUST compliance. The use of cloud technology provides a multitude of benefits, some of which include scalability, cost effectiveness, and enhanced accessibility. On the other hand, it also presents difficulties in terms of data security, privacy, and compliance with regulatory requirements. The implementation of strong solutions that are in accordance with the standards of HIPAA and HITRUST is necessary for healthcare organisations in order to solve these difficulties. In the first place, the study conducts an investigation of the key concepts of HIPAA and HITRUST, underlining the relevance of these principles in protecting patient information. At the same time as HIPAA is responsible for establishing national standards for the protection of sensitive patient data, HITRUST is responsible for providing a framework that is certifiable and incorporates several security and privacy criteria. In order to design a compliance plan, it is vital to have a better understanding of these frameworks.
The Role of Predictive Analytics in Inventory Management
Authors: Shashwat Agrawal  , Venkata Ramanaiah Chintha  , Vishesh Narendra Pamadi  , Anshika Aggarwal  , Prof.(Dr.) Punit Goel
Published: September 2024

The use of predictive analytics has emerged as a game-changing instrument in the field of stock management. This tool provides a data-driven strategy to optimise stock levels, reduce costs, and improve operational efficiency. The purpose of this abstract is to investigate the role that predictive analytics plays in revolutionising how inventory management processes are carried out. This is accomplished by using historical data, statistical algorithms, and machine learning approaches to estimate future inventory requirements.
At its foundation, predictive analytics is doing an analysis of previous inventory data, sales trends, and external variables in order to forecast future demand with a high degree of precision. When it comes to inventory management, traditional methods sometimes rely on static models and gut reactions, which may result in problems such as overstocking or stockouts. Alternatively, predictive analytics offers a dynamic and data-informed viewpoint, which enables firms to alter their inventory strategy in a proactive manner as necessary. Companies are able to estimate demand changes based on seasonality, market trends, promotions, and other factors when they integrate predictive models into their operations. This results in more accurate inventory planning.
User-Centric Design in Product Development
Authors: Siddhey Mahadik  , Fnu Antara  , Pronoy Chopra  , A Renuka  , Om Goel
Published: September 2024

User-centric design is a core approach in product development that places an emphasis on the requirements, preferences, and experiences of end users across the whole process of design and development. This technique is founded on the premise that successful products are those that closely coincide with the expectations of consumers and increase the overall pleasure of those people. Organisations are able to develop products that are not only functional but also intuitive, engaging, and successful if they place an emphasis on user experience (UX) and incorporate input directly from the audience they are trying to reach.
In most cases, the first step in the user-centric design process is to get a knowledge of the user's requirements by doing extensive research using techniques such as interviews, questionnaires, and observation. It is at this phase that the user's pain points, objectives, and behaviours are identified. These identifications serve as the foundation for the creation of user personas and scenarios. The designers are able to empathise with a variety of user viewpoints and predict how they will engage with the product by using these personas, which represent diverse portions of the target population.
GANs for Enhancing Wearable Biosensor Data Accuracy
Authors: Nishit Agarwal  , Venkata Ramanaiah Chintha  , Vishesh Narendra Pamadi  , Anshika Aggarwal  , Vikhyat Gupta
Published: September 2024

Wearable biosensors have become indispensable in the realm of health monitoring, providing real-time data on physiological parameters such as heart rate, temperature, and glucose levels. Despite their increasing adoption, these devices often face challenges related to data accuracy, mainly due to sensor noise, signal artifacts, and inconsistencies in sensor quality. Such inaccuracies pose a significant barrier to the reliable use of biosensors in healthcare, reducing their effectiveness for both clinical applications and personal health tracking. To address these limitations, the implementation of Generative Adversarial Networks (GANs) offers a novel and promising solution.
GANs consist of two neural networks—the generator and the discriminator—that operate in an adversarial manner. The generator creates synthetic data samples, while the discriminator attempts to distinguish between real and generated data, leading to the continuous refinement of data quality. In the context of wearable biosensors, GANs hold immense potential to improve data accuracy by filtering out noise, correcting signal distortions, and producing high-fidelity synthetic data that mimic real biosensor outputs.
OPLAN LARO: OPERASYONG PAGPAPAIGTING SA PAKIKILAHOK SA KLASE NG MGA MAG-AARAL NG IKA-10 BAITANG SA TUGON NG LARONG AKTIBO, REALISTIKO AT ORGANISADO
Authors: Donnalyn O. Manuel  , Criscel C. Melliza  , Jessa M. Tuba
Published: September 2024

Ang pag-aaral na ito ay isinagawa upang tukuyin ang makabuluhang pagkakaiba ng pakikilahok ng mga mag-aaral sa klase. Kabilang din ang pagsuri sa makabuluhang pagkakaiba ng pakikilahok ng mga mag-aaral sa pagitan ng pre-test at post-test bago at pagkatapos ipatupad ang interbensyong Oplan LARO (Larong Aktibo, Realistiko at Organisado). Ang pananaliksik na ito ay ginamitan ng pre-experimental na disenyo. Ang mga respondente ay kinapalooban ng 36 na mga mag-aaral mula sa baitang 10 – seksyon Rizal ng Luna National High School. Sa resulta ng pag-aaral, ang antas ng pakikilahok ng mga mag-aaral sa klase bago ang ipinatupad ang interbensyon ay may kabuoang mean na 2.65, ibig sabihin bihira lamang itong naipapakita. Samantala, pagkatapos naman ipinatupad ang interbensyon ay may kabuoang mean na 4.68, ibig sabihin na laging na itong naipapakita. Ipinakita rin sa pag-aaral na ito na may makabuluhang pagkakaiba ang antas ng pakikilahok sa klase ng mga mag-aaral bago at pagkatapos ng interbensyon dahil sa < .001 na p-value. Nangangahulugan lamang na may malaking papel na ginagampanan ang interbensyong Oplan LARO (Larong Aktibo, Realistiko at Organisado) sa pagpapaunlad ng pakikilahok sa klase ng mga mag-aara
MGA SUSING SALITA: Pakikilahok ng mga mag-aaral sa klase, pre-test, post-test, pre-experimental
RESEARCH ON THE IMPACT OF ONLINE REVIEWS ON CONSUMER DE-CISIONS WHEN CHOOSING GOODS AND SERVICES ON MARKETPLACES
Authors:   Federal State Budgetary Educational Institution of Higher Education ", Zakirova D.F. ,   Saint-Petersburg State Technological Institute (Technical University)"
Published: September 2024

In the modern world, the Internet has be-come not only an effective distribution channel, but also one of the key platforms for the exchange of views and experience between consumers. Given the growth of online sales, understanding the impact of reviews on consumer decisions is becom-ing more relevant. Feedback can both at-tract new customers and alienate potential audiences, as confirmed by various studies [1]–[14], but the mechanisms of this influ-ence and its scale require additional detail and systematization. The results of a study of the impact of reviews on marketplaces on consumer solutions when choosing goods and services are of interest from the point of view of developing a marketing strategy in an organization on these online sites.
RELEVANT PRINCIPLES AND INNOVA-TIVE TOOLS FOR MANAGING THE DE-VELOPMENT OF TRANSPORT SYS-TEMS IN THE REGIONS OF RUSSIA
Authors:   Autonomous Non-Profit Organization of Higher Education ", Liubarskaia M.A. ,   Russian New University", Kirillov M.A. ,   Autonomous Non-Profit Organization of Higher Education "Russian New University"
Published: September 2024

The authors substantiate the importance of constantly updating the principles and tools for managing regional transport systems. In the process of the study, stages were iden-tified, the passage through which can be observed in the modern history of the for-mation and development of these systems in the Russian Frderation. Among the prin-ciples that are relevant in the current condi-tions, the authors named complexity, adaptability, sustainability and efficiency. As a scientific novelty, it is worth noting the analysis of the introduction of modern tech-nologies and tools in the management of transport systems. These technologies and tools are aligned with the classical func-tions of management, including forecasting, planning, organization, accounting, analy-sis, evaluation, control, feedback
RUSSIAN RETAIL TRADE IN RUSSIAN FEDERATION: CURRENT STATE
Authors:   Federal State Autonomous Educational Institution of Higher Education ", Betanov A.P. ,   Saint-Petersburg State Polytechnic University of Peter the Great", Yujing Qi ,   Federal State Autonomous Educational Institution of Higher Education "Saint-Petersburg State Polytechnic University of Peter the Great", Bakharev V.V. ,   Federal State Autonomous Educational Institution of Higher Education "Saint-Petersburg State Polytechnic University of Peter the Great"
Published: September 2024

The present paper contains a description of article the current state of the retail market in the Russian Federation. The main trends of the development of retail in Russia are shown. These trends include the growth of digital retail, the emergence of new retail formats adapted to the changing purchas-ing power of the population, the entry of federal retail operators into new regional markets and the acquisition of small retail companies by large chains. A major threat to the sustainable development of retail may be a shortage of labor, which requires a revision of the policies of retail companies in the field of personnel management.
EXPERIENCE IN IMPLEMENTING ESG-STRATEGY IN CHINA: TRENDS AND RISKS
Authors:   Saint-Petersburg State University of Economics, Kuchumov A.V. , Liyun Xie ,   Saint-Petersburg State University of Economics, Eremicheva P.Yu. ,   Saint-Petersburg State University of Economics
Published: September 2024

The article reflects the importance of intro-ducing ESG principles into the policies of Chinese organizations and presents the main problem of applying the ESG model. The authors reviewed statistical data on key indicators and studied the main devel-opment trends of Chinese enterprises that encourage the use of ESG strategies. The work examines the features of integrating ESG models into the policies of Chinese companies, reveals the main risks associ-ated with the modern agenda, and analyzes ESG strategy as a mechanism for reducing business risks, with an emphasis on the experience of organizations representing the Chinese market
FOREIGN PRACTICE OF MASS SPORT FUNDING
Authors:   Federal State Budgetary Educational Institution of Higher Education ", Lobastova M.V. ,   Saint-Petersburg State University of Economics"
Published: September 2024

The purpose of the research is to study the foreign experience of the financial provision for mass sport and to identify possible sources of its funding using the example of Great Britain. Particular attention is paid to the problems of major sporting events financing that can attract global audience and sponsors seeking to increase the attractiveness of their brands and products. The conducted research allowed us to identify areas for attracting financial sources for sports organisations of various levels
CHOOSING AN OPTIMAL STRATEGY OF DEVELOPMENT OF THE INCLUSIFE TOURISM ECOSYSTEM: AN ECONOMIC AND MATHEMATICAL MODEL
Authors:   Federal State Autonomous Educational Institution of Higher Education ", Barykin S.E. ,   Saint-Petersburg State Polytechnic University of Peter the Great", Vashkevich N.P. ,   Federal State Autonomous Educational Institution of Higher Education "Saint-Petersburg State Polytechnic University of Peter the Great"
Published: September 2024

The use of an ecosystem approach for the development of inclusive tourism can signif-icantly increase the availability of tourism services for people with special needs. At the same time, it is extremely important to choose an optimal strategy for the for-mation of this ecosystem, taking into ac-count a large number of options for the par-ticipation of potential stakeholders. The goal of the present paper is to develop an economic and mathematical model of the inclusive tourism ecosystem which can be used to substantiate the choice of the opti-mal strategy for its development.
METHODOLOGICAL APPROACHES TO ASSESSING THE EFFECTIVENESS AND FINANCIAL STABILITY OF BANKING ACTIVITIES
Authors:   Stavropol State Agrarian University, Stavropol, Russia, Glotova Irina I. , Tomilina Elena P. ,   Stavropol State Agrarian University, Stavropol, Russia, Zabarovsky Kirill D. ,   Stavropol State Agrarian University, Stavropol, Russia
Published: September 2024

The modern economic development of any state is largely determined by the effectiveness of banking activities of credit and financial organizations. Currently, banks perform not only the usual functions for most to provide loans or to service customer accounts. Today, banking organizations are one of the main investors in the development of the socio–economic sphere of society. With substantial financial resources at their disposal, they contribute to the development of important public and private projects. Nevertheless, the main source of these resources is still precisely banking, which, due to the growing role of banking organizations in the development of the state, needs to be regularly evaluated for effectiveness.
REFORM AND RESEARCH OF EXPERIMENTAL TEACHING OF PATHOGENS AND IMMUNOLOGY
Authors:   Shelkovskaya secondary school No. 4 named after Ak.-H. Kadyrov, Shidaev Said-Hussein Kh. , Ataeva Aminat A. ,   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov, Vakaraeva Malika M. ,   Kadyrov Chechen State University
Published: September 2024

“Pathogens and Immunology” is a professional and practical basic medical course that serves as a link between fundamental medicine and clinical medicine. Through experimental classes, students can deepen their understanding of theoretical knowledge, improve their ability to analyze and solve problems, and develop rigorous scientific thinking. Thus, the quality of teaching in the experimental class and the quality of teaching directly affect the quality and abilities of students. The traditional learning model is mainly based on theoretical learning and complemented by experimental learning. Most of the experimental projects are verification experiments. Therefore, it is extremely necessary to reform and investigate the experimental doctrine of pathogens and immunology. After reforming the experimental teaching of this subject by developing reasonable learning plans and optimizing assessment methods, students’ enthusiasm for learning, teaching quality and learning effectiveness have improved significantly
A TIME-FREQUENCY BASED SUSPICIOUS ACTIVITY DETECTION FOR ANTI-MONEY LAUNDERING
Authors: B.Srinivasulu  , T. Sravani  , Sravani T. Ajanta , T. Vennela
Published: September 2024

The essential tool used by criminals to introduce the profits of their crimes into the financial system is money laundering. Financial institutions have the main obligation for identifying any questionable conduct connected to money laundering. Over 90% of the present systems at these institutions are false positives and rule-based, making them unproductive. The current rule-based systems in use are to be replaced with data science-based anti-money laundering (AML) models that focus on the temporal aspects of transaction behavior and CRM elements. Because there are hundreds of conceivable combinations of customer and account features, it is difficult to do feature engineering with a sufficient level of accuracy. In this paper, we develop a new feature set based on time-frequency analysis to enhance the detection performance of suspicious transaction monitoring systems for AML systems. This feature set leverages 2-D representations of financial transactions. As a machine learning technique, random forest is used, while simulated annealing is used for hyperparameter tweaking. The effectiveness of the developed algorithm is shown in scenarios that are realistically relevant by testing it on actual banking data. It is shown that the time-frequency characteristics may distinguish between things that are suspicious and those that are not. As a consequence, these characteristics significantly raise the current data science-based transaction monitoring systems' area under curve results (above 1%). With an F-score of 59.05%, a false positive rate of 14.9% has been attained using just time-frequency characteristics. The F-Score increases to 74.06% and the false positive rate is reduced to 11.85% when transaction and CRM elements are included.
Internally-crosslinked alginate dialdehyde/alginate/gelatin-based hydrogels as bioprinting inks for prospective cardiac tissue engineering applications
Authors: Stola Giovanni Paolo , Paoletti Camilla , Nicoletti Letizia , Paul Geo , Cassino Claudio , Marchese Leonardo , Chiono Valeria , Marcello Elena
Published: September 2024

Cardiovascular diseases represent a worldwide social and economic challenge, due to heart tissue limited regenerative capabilities. 3D bioprinted cell-laden constructs are a promising approach to develop patches for cardiac regeneration or in vitro models for new drug preclinical discovery and validation. However, the development of bioinks with optimal mechanical, rheological, and biological properties is still a challenge. Although alginate (Alg)-based bioinks have been extensively explored, such hydrogels lack cell adhesion properties and degradability. Additionally, 3D Alg structures are usually obtained by micro-extrusion bioprinting exploiting conventional external cross-linking methods, which introduce inhomogeneities and unpredictability in construct formation. This work exploits Alg internal ionic gelation mechanism to obtain homogeneous self-standing multilayered 3D printed constructs without employing support baths or post-printing crosslinking treatments, combining an insoluble calcium salt (calcium carbonate, CaCO3) with an acidifying agent (D-(+)-Glucono-1,5-lactone, GDL) to promote controlled release of calcium ions. Alg was blended with oxidized alginate (ADA) and gelatin (Gel) to achieve degradable and cell adhesive hydrogels for cardiac tissue engineering. Firstly, ADA/Alg bioink composition was tailored by varying polymer weight ratio (keeping ADA as the main component) and calcium ions concentration to achieve cardiac tissue-like viscoelastic properties. Then, the amount of Gel in ADA/Alg hydrogels was optimized to support adult human cardiac fibroblasts (AHCFs) adhesion, producing shear thinning inks with tunable viscoelastic properties (G’ 650-1300 Pa) and degradation profile (40-80% weight loss after 21 days in phosphate buffered saline, PBS) by varying Gel concentration. ADA/Alg/Gel hydrogels showed a shear thinning behavior suitable for 3D bioprinting and dependent on ink stabilization time, due to the gradual pH-triggered release of calcium ions over time. AHCFs-laden ADA/Alg/Gel bioinks could be successfully printed producing scaffolds with high shape fidelity and good cell viability post-printing. Finally, 3D AHCF-laden and H9C2-laden ADA/Alg/Gel bioinks with the highest gelatin content (25% w/w) allowed cell adhesion after 24 hours of incubation, showing potential application for cardiac tissue modelling. This research presented a comprehensive framework for advancing the design of bioink formulations enabling the printing of cell-adhesive and self-supporting constructs.
3D-printed polycaprolactone-magnetic nanoparticles composite multifunctional scaffolds for bone tissue regeneration and hyperthermia treatment
Authors: Kanwar Susheem , Vijayavenkataraman Sanjairaj
Published: September 2024

Cancer management after tumor resection is characterized by two critical needs: (i) rehabilitation of the resected tissue and (ii) preventing post-surgical tumor recurrence by destroying any residual tumors. The state of the art in literature is limited because it tackles these two major priorities individually, it achieves tissue regeneration via autologous grafting and prevents tumor recurrence through chemotherapy. In this paper, extrusion 3D printing has been employed to manufacture composite multi-functional scaffolds with polycaprolactone (PCL) as a polymeric matrix and magnetic nanoparticles (MNPs) in a 0 to 50 wt% ratio, that would aid in bone regeneration and cancer management via magnetic hyperthermia treatment. The fabricated scaffolds were evaluated for their mechanical, magnetic and thermal characteristics. The Young’s modulus of the scaffolds increased multi-fold with increasing concentration of MNPs added to PCL (26.88±9.02 MPa for pure PCL to 229.06±37.05 MPa for PCL/50 wt% MNP scaffolds). PCL/MNP scaffolds displayed a directly proportional correlation between MNP concentration and saturation magnetization. While the in vitro tests showed a statistically significant cell growth of human Mesenchymal Stem Cells (hMSCs) over 7 days for all MNP concentrations, only the 50% MNP scaffold showed an increase in temperature over 41oC when subjected to an alternating magnetic field making it suitable for the hyperthermia treatment. On application of alternating magnetic fields to PCL and PCL/50 wt% MNP scaffolds, there was an increase in hMSCs proliferation and decrease in Bone cancer cells proliferation, thus proving the potential to be used as a multi-functional scaffold for post-surgical bone cancer management.
 
The Internet of Things (IoT): Applications, Investments, and Challenges for Enterprises
Authors: - Md Nadil Khan , - Tanvirahmedshuvo , - Md Risalat Hossain Ontor , - Nahid Khan , - Ashequr Rahman
Published: September 2024

The rise of the Internet of Things (IoT) has triggered changes, in industries offering improved efficiency data informed decision making and fresh business models. This document explores the world of IoT looking into its uses investment prospects and obstacles faced by businesses. By conducting a review of existing literature, we shed light on the state of IoT technologies by analyzing recent studies and publications. Our approach involves an examination of trends in adoption strategies for evaluating investments and the main challenges encountered during IoT implementation. We delve into the range of applications for IoT in sectors like retail, manufacturing and healthcare spotlighting technologies and successful case studies. Additionally, we evaluate investment opportunities in technologies by comparing methods such as Net Present Value (NPV) and Real Option Approach to assess investments. The document also addresses hurdles related to data management issues, privacy risks, security vulnerabilities and the complexities of interconnected networks. We wrap up with a summary of insights from our research findings along with recommendations, for enterprises looking to navigate the evolving landscape of IoT.
Assessing the Status of Self-care Behavior in Patients with Type 2 Diabetes in Binzhou City: A Cross-sectional Study
Authors: - Qi Ying , - Engracia S. Arceo
Published: September 2024

Worldwide, diabetes is a silent epidemic that claims 4.2 million lives worldwide each year. Experts predict that by 2045, one in 10 people will be affected by the disease. In China, with the change of lifestyle in recent years, the number of obese and overweight people is increasing, and the incidence of diabetes is also rising year by year, which makes the health education of diabetic patients particularly important. The purpose of this study was to assess self-care behavior and its influencing factors. This study is an analytical cross-sectional study. Data will be collected through questionnaires. Participants will be divided into two groups based on the questionnaire results: high adherence and low adherence. In this group of questionnaires, the Chinese version of the Diabetes Self-care Questionnaire (DSMQ) (r>0.60, Cronbach’s alpha=0.764) will be used, and another questionnaire which will determine the influencing factors will be designed by the author . The convenience sampling method will be used to select the survey objects. The minimum sample size for this study will be 384. Of the 377 participants,171 (45.36%) were female and 296 (54.64%) were male. The mean HbA1C was 8.807%±3.975%. The average BMI was 22.198±2.940kg. The self-care behavior score of the subjects was 4.368±2.388, which was in the sub-optimal nursing level.
Anatomical and Physiological Perspectives of Various Srotas: A Comprehensive Review
Authors: - Dr. Vimala Khatri , - Dr. Rubina Bano , - Dr. Sneha Ghawale , - Dr. Kiran
Published: September 2024

Abstract:
Background: In Ayurveda, Srotas are fundamental components of the body's transport system. Acharya describe numerous Srotas that facilitate the balance of Dosha, Dhatu, and Mala. These channels, which can vary in size from micro to macroscopic, are crucial for a range of physiological functions. Aim: To explore the anatomical and physiological aspects of Srotas in Ayurveda, focusing on their role in maintaining bodily balance and their impact on health and disease. Material & Methods: This review synthesizes information from classical Ayurvedic texts, such as the Charaka Samhita, to clarify the concept of Srotas. It explores their structural and functional roles, including absorption, secretion, transportation, drying, excretion, and separation. Discussion: The term 'Srotamsi' includes both Anusrotas( individual cells) and Sthula Srotas (organ systems), derived from the Sanskrit root 'Stru-Strabane,' indicating movement and filtration. Srotas are crucial for the flow of substances and significantly impact the state of Dosha, either aggravating or pacifying them. Proper functioning of Srotas is vital for maintaining health and restoring balance; dysfunction of Srotas can lead to various pathological conditions. Conclusion: A thorough understanding of Srotas from anatomical and physiological perspectives is essential for appreciating their role in health and disease. This review highlights the importance of maintaining Srotas functionality to prevent and address health issues in line with Ayurvedic principles.
Disaster Resiliency of the Mabuseños
Authors: - Rosine O. Labado , - Aldin C. Lorenzo , - Archile C. Abogadie , - Meri - Lena G. Dionisio , - Salve M. Ferrer , - Donna J. Dividina
Published: September 2024

The community has been experiencing a lot of anxiety in the midst of the pandemic that is being experienced right now. An individual who is experiencing these situations may suffer from mental health issues while others are resilient and can face life. This study investigated the level of resiliency of barangay personnel to against disaster. Four hundred sixty - nine respondents were identified and surveyed using an adapted questionnaire. Frequency count and percentage were used to determine the profile of the respondents in terms of location, age, sex, civil status, highest educational attainment, position, and monthly income. ANOVA and t-tests were used to test the differences and Pearson R for the test of the relationship.
The majority of the respondents are from Caidquid, middle–aged, female, married, college level, BHW, and Tanod, and have an average income. They were generally resilient, fairly resilient in terms of physical, and resilient in terms of psychological, emotional, social, and environmental.
Household Waste Water Treatment using Activated Charcoal: An Effective and Sustainable Approach
Authors: - Shivani Yadav , - Farhan Khan , - Kaminee Rathore
Published: September 2024

Effective household wastewater management is crucial for environmental sustainability and public health, especially in areas with limited advanced treatment infrastructure. This study explores the use of activated charcoal as a cost-effective and efficient method for treating household wastewater. Known for its high adsorption capacity, activated charcoal was evaluated for its ability to remove key contaminants from wastewater collected from residential sources such as kitchens, bathrooms, and laundry areas.
The research utilized both batch adsorption tests and column filtration experiments. In the batch tests, wastewater samples were treated with varying doses of activated charcoal (2, 5, 10, and 15 g/L) over different contact times (30 minutes to 4 hours). The results showed that activated charcoal effectively reduced Total Suspended Solids (TSS), Chemical Oxygen Demand (COD), and Biological Oxygen Demand (BOD), with average reductions of 75%, 65%, and 70%, respectively. Additionally, activated charcoal demonstrated significant effectiveness in removing heavy metals and organic compounds, with removal efficiencies ranging from 60% to 80% depending on the contaminant type and operational conditions. The optimal treatment conditions were found to be a dosage of 10 g/L and a contact time of 2 hours. Future research could focus on optimizing regeneration processes and exploring hybrid systems that combine activated charcoal with other treatment technologies to further enhance performance.
Evaluation of Antioxidant and Anti-hyperlipidemic Effect of Tridax Procumbens L. Flower Extract by in Vitro Method
Authors: - Pradeepa P , - N L Gowrishankar , - Sony Priya P D , - Sreelakshmi M R , - Chandana K P , - Rafna Femi , - Swathi Sivan
Published: September 2024

This study assessed the in vitro antioxidant and anti-hyperlipidemic properties of Tridax procumbens Linn methanolic and hydro alcoholic flower extract. The amount of antioxidant activity was measured using techniques including DPPH (2, 2-diphenyl-2-picryl hydroxyl) and nitric oxide. We analyzed the percentage of different free radicals that were scavenged using ascorbic acid, a common antioxidant. Using the TBARS assay and lipid peroxidation measurements, the extracts anti-hyperlipidemic potential was also assessed. Furthermore, the phytochemical analysis of the floral extracts that were methanolic and hydroalcoholic revealed the presence of flavonoids, phenols, saponins, terpenoids, triterpenes, alkaloids, glycosides, and tannins in substantial amounts. Significant antioxidant activity was found (P<0.001) for DPPH scavenging at various flower extract doses. The methanolic extract's IC50 value and % inhibition were higher than hydro-alcoholic extracts.
Contribution of Responsive Governance to Personal Security of Crime Victims in Kenya
Authors: - Mary Mwenje , - Dennis Ndambo , - Kenneth Mutuma
Published: September 2024

This study explored the critical role of responsive governance in enhancing the efficacy of victim assistance programs, with a particular focus on Kenya’s criminal justice system. By examining Kenya's low ranking on the World Justice Project's Rule of Law Index and comparing it with other nations such as the U.S., U.K., Germany, and Nigeria, the study highlights significant gaps in the protection of crime victims' rights. Employing a mixed-methods approach, this study investigated how governance impacts victim support by analyzing data from surveys and interviews with victims, government officials, law enforcement, and advocacy groups in Nairobi. The research identified the key principles for successful victim support, including inclusivity, transparency, accountability, and flexibility. It underscores the need for victim-centered approaches that prioritize accessibility, empathy, respect, confidentiality, and empowerment. The findings reveal both successes and challenges in current programs, with issues such as inadequate funding and limited collaboration affecting service delivery. The study advocates for the establishment of a Victim Support Agency (VSA) in Kenya to centralize victim support, enhance transparency, and foster effective stakeholder collaboration. The study recommends a holistic, coordinated, and well-funded approach that includes continuous improvement of victim support programs to address the existing gaps and advance justice and support for crime victims.
Assessment of an Advanced Water Filtration System for Enhanced Water Purification
Authors: - Sangeeta Sahu , - Jayant Supe , - Kaminee Rathore
Published: September 2024

The study confirms the effectiveness of a state-of-the-art water filtration system in purifying urban tap water, river water, and groundwater. The system, which uses activated carbon, ceramic, and reverse osmosis (RO) filtration, significantly improved water quality by removing physical, chemical, and biological contaminants. Key results include: The system achieves a turbidity reduction of up to 99.5%, adhering to WHO standards. The system removes over 96% of volatile organic compounds (VOCs) and chlorine, and more than 99% of heavy metals like lead and arsenic. The water is completely free of harmful bacteria, guaranteeing its microbiologic safety. There has been a 98.2% reduction in total dissolved solids (TDS) in groundwater. The study highlights the system's adaptability to diverse environments, including urban, rural, and industrial settings. Future research could focus on improving the system's energy
efficiency and sustainability.
A Comparative Study of Pigtail Catheter and Malecots Chest Tube Thoracostomy in the Management of Empyema Thoracis at a Tertiary Care Center in North India
Authors: - Vignesh.K , - Loknath. B , - Pravinraj. S
Published: September 2024

Background: The study aimed to compare the effectiveness of pigtail catheter vs. malecot chest tube thoracostomy in the management of empyema thoracis and pyopneumothorax. Methods : This prospective randomised interventional study was conducted in the Department of Respiratory Medicine at a tertiary care centre in north India between September 2020 and August 2021. One hundred patients, qualified as per inclusion criteria, were included in the study, and randomization was done using the random number table method. After allocation concealment and randomization, the intervention was done in the sense that Group A (51 cases) received a pigtail catheter (14F) and Group B (49 cases) received a malecot chest tube (28F) (a total of 100 cases). After the intervention, both groups were observed for 14 days. On the 14th day, the data for the primary observations (radiological clearance on day 1, day 7, day 14th, and mean duration of hospital stay) and secondary observations (postoperative pain score, post-procedure complications) were noted, and statistical analysis was done. Results: Radiological clearance in the malecot chest tube group (28F) is better on days 1 (0.55±0.13) and 7 (0.75±0.08) than in the pigtail catheter group on day 1 (0.52±0.18) and day 7 (0.72±0.11). But, radiological clearance on day 14 in the malecot chest tube group (0.91±0.06) and the pigtail catheter group (0.91±0.08) is comparatively equal (p<0.05). The mean duration of hospital stay and pain scores were better in the pigtail catheter group than in the malecot chest tube group. Conclusions: Our study suggests pigtail catheters are a safe and effective method and should be considered in the management of empyema thoracis and pyopneumothorax
Quantum Machine Learning: Leveraging Quantum Computing for Enhanced Learning Algorithms
Authors: - Sonia Rani , - Ravinder Kaur , - Chitra Desai , - R.P.Ambilwade
Published: September 2024

The paper "Quantum Machine Learning: Leveraging Quantum Computing for Enhanced Learning Algorithms" explores the integration of quantum computing principles into classical machine learning techniques, aiming to address limitations such as scalability and computational inefficiency. It presents the foundational concepts of quantum computing, including superposition and entanglement, and their application in accelerating machine learning processes. The study emphasizes the potential for quantum algorithms to significantly improve the performance of machine learning tasks by processing large datasets more efficiently and exploring larger hypothesis spaces.
Key quantum machine learning algorithms discussed include Quantum Support Vector Machines (QSVM), Quantum Principal Component Analysis (QPCA), and Quantum Neural Networks (QNN), each of which leverages quantum mechanics to overcome the computational barriers faced by classical algorithms. The Quantum Approximate Optimization Algorithm (QAOA) is also highlighted for its ability to optimize machine learning models more effectively. While the theoretical benefits of Quantum Machine Learning (QML) are promising, the practical application of these techniques is currently limited by the constraints of existing quantum hardware. This research contributes to the emerging field of QML by examining its potential advantages and future implications in addressing complex data processing challenges.