bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation as the bridge between science and clinic
Authors: Casarin Renato Corrêa Viana , Nahas Rodrigo , Denardi Ricardo , Lopes Claudio Julio , Dias Alexandra , Campos Glecio Vaz de , Messora Michel
Published: October 2022

When faced with new dental treatment options we must always remember that countless years, countless tests, countless patients and countless scientists have put all the inspiration, sweat and life into this effort. There is no innovation without inspiration. There is no future without innovation.
Assessment of a printed education material for patients undergoing periodontal treatment: a randomized clinical trial
Authors: Nodari Daniela , Pilger Diogo , Ferreira Maria Beatriz Cardoso , Piardi Carla Cioato , Weidlich Patricia
Published: October 2022

OBJECTIVE: to evaluate the effectiveness of printed educational material (PEM) as an aid in promoting the oral health of patients undergoing periodontal treatment. MATERIALS AND METHODS: Conducting a randomized pilot clinical trial with 20 individuals diagnosed with gingivitis. Patients with at least 30% of visible plaque and 30% of gingival bleeding were included. On the first day of treatment, all patients received instruction, training and motivation for oral hygiene, and answered a test of knowledge about periodontal diseases. Ten participants were randomized for each group. After, the test group received an PEM at the end of the first consultation. After 4 to 5 weeks, clinical examination and knowledge test were repeated. The clinical examination was performed by a blind examiner. Significant increase in the number of “right” questions and significant reduction in the number of “I don’t know” answers in the test group, compared to the control group (P <0.001). The test group showed significantly lower ISG (30.5%; 95% CI: 25.29 – 35.62), compared to the control group (46.8%; 95% CI: 41.63 – 51.96; P <0.001). There were no losses in the follow-up. CONCLUSION: the previously validated MEI proved to be effective for improving knowledge and the clinical condition of patients undergoing gingivitis treatment. Patients with at least 30% of visible plaque and 30% of gingival bleeding were included. This study was registered in the Brazilian Registry of Clinical Trials, under number RBR-8nc8t9y.
Pendekatan Penal Dalam Kerangka Politik Kriminal Untuk Menanggulangi Tindak Pidana Tambang Galian C Di Wilayah Wonosobo
Authors: Larasati Agung Budhi , Pujiyono Pujiyono , Azhar Muhamad
Published: October 2022

Kabupaten Wonosobo adalah kawasan konservasi, berdasarkan Surat Keputusan Menteri Energi dan Sumber Daya Mineral, Republik Indonesia Nomor 3672K / 30 / MEM / 2017 Tentang Penentuan Wilayah Pertambangan di Jawa dan Bali. Tujuan dari penelitian ini adalah untuk mengetahui upaya pendekatan penal dan solusi pencegahan penambangan ilegal di Candimulyo, Kecamatan Kertek, Kabupaten Wonosobo. Metode penelitian yang digunakan adalah metode penelitian yuridis empiris dengan menggunakan pendekatan hukum atau peninjauan terhadap peraturan terkait penambangan ilegal di Candimulyo, Kecamatan Kertek, Kabupaten Wonosobo. Proses penyidikan dalam kasus tindak pidana tambang galian C dilakukan dilakukan oleh pihak Kepolisian Resor Wonosobo, penyidik PNS dalam hal ini adalah Satpol PP, Kejaksaan Negeri Wonosobo sebagai penuntut umum dan Pengadilan Negeri Wonosobo dalam perkara tindak pidana tambang tanpa izin di wilayah kabupaten Wonosobo dilakukan menggunakan upaya penal yang bersifat represif karena dilakukan setelah terjadinya kejahatan dengan menerapkan sanksi yang ada didalam peraturan perundang-undangan.
Kebijakan Hukum Pidana Dalam Upaya Penanggulangan Cyber Prostitution
Authors: Safitri Anisya Ines , Makaminan Aldo Andrieyan Putra , Prasetyo Mujiono Hafidh
Published: October 2022

Bergesernya kehidupan masyarakat ke arah digitalisasi berdampak pada timbulnya kejahatan di dunia siber. Salah satu kejahatan yang menjadi perhatian di masyarakat saat ini adalah prostitusi di dunia siber atau yang biasa dikenal dengan istilah cyber prostitution. Kasus cyber prostitution di Indonesia saat ini masih marak terjadi sampai saat ini sehingga perlunya suatu kebijakan hukum pidana dalam upaya menanggulangi hal tersebut.  Tujuan penulisan ini untuk mengkaji kebijakan hukum pidana dalam upaya penanggulangan cyber prostitution berdasarkan hukum positif saat ini dan di masa yang akan datang. Dalam hasil dan pembahasan, pengaturan mengenai cyber prostitution berdasarkan hukum positif saat ini diatur dalam KUHP, UU ITE dan UU Pornografi di mana pengaturan tersebut belum secara tegas mengatur mengenai cyber prostitution. Kebijakan hukum pidana dalam upaya penanggulangan cyber prostitution di Indonesia di masa yang akan datang melalui kajian perbandingan dengan negara lain dan RUU KUHP dapat menjadi acuan untuk pengaturan hukum positif yang lebih baik. Hal ini dikarenakan pengaturan mengenai cyber prostitution sudah semakin tegas karena dalam pengaturan di negara Swedia, yang dapat dikenakan pidana tidak hanya PSK saja tetapi pemakai jasa tersebut juga dapat dipidana. Sedangkan dalam RUU KUHP sudah terjadi perluasan dimana subyek hukumnya lebih diperinci dalam beberapa kelompok.
Kebijakan Formulasi Pidana Mati Dalam Pembaharuan Hukum Pidana Indonesia
Authors: Anugrah Roby , Desril Raja
Published: October 2022

Pidana mati merupakan jenis pidana yang sangat besar pengaruh dan dampak nya, sehingga perdebatan mengenai pro dan kontra pidana mati masih terus berlangsung sampai dewasa ini. Indonesia sebagai negara hukum yang sedang melakukan pembaharuan hukum pidana terutama lewat pembentukan KUHP Nasional tidak terlepas dari problem mengenai apakah pidana mati tetap dipertahankan dalam KUHP Nasional atau menghapuskan pidana mati dalam stelsel pidana. Penelitian ini bertujuan untuk mengetahui kebijakan formulasi pidana mati dalam perundang-undangan pidana Indonesia di masa sekarang, dan menganalisis kebijakan formulasi hukum yang dicita-citakan tentang pidana mati di Indonesia pada masa akan datang. Penelitian ini menggunakan metode kualitatif dengan pendekatan yang bersifat yuridis normatif dan spesifikasi penelitian deskriptif analitis. Penelitian ini menghasilkan fakta bahwa hukum di Indonesia sekarang masih mengatur pidana mati sebagai pidana pokok sehingga masih ada pertentangan antara kelompok pro dan kontra pidana mati. Pidana mati pada pembaharuan hukum pidana di Indonesia mengambil jalan tengah dengan tidak memihak antara dua golongan tersebut. Pidana mati pada masa akan datang adalah wujud konkret terhadap hak asasi manusia sesuai dengan wawasan nasional dan internasional.
Peran Pendidikan Pancasila Terhadap Pencegahan Penyebaran Terorisme Di Kalangan Pelajar
Authors: Pradana Rizky , Setiyono Joko
Published: October 2022

Penanggulangan terorisme di Indonesia berada pada fase pencegahan radikalisme. Dekade ini (2010 – 2020) terdapat temuan yang mengindikasikan paparan radikalisme dikalangan anak – anak. Paparan radikalisme dini disinyalir menyebabkan munculnya bibit teroris baru dan juga regenerasi organisasi teroris tertentu yang berkembang secara pesat. Tujuan gagasan konseptual memberi masukan kepada Pemerintah agar bertindak melalui Kementerian Pendidikan dan Kebudayaan, Badan Nasional Penanggulangan Terorisme dan Badan Pembinaan Ideologi Pancasila yang memiliki peranan penting pada pencegahan dan penanggulangan radikalisme dikalangan anak khususnya pelajar, dengan menitik beratkan pada dasar hukum lembaga negara guna pembentukan sebuah padu kerja antara tiga lembaga pemerintah. Gagasan ini menggunakan teori pertanggungjawaban negara dan teori lembaga negara yang menuntun padu kerja antara Dinas Pendidikan dan Kebudayaan, Badan Nasional Penanggulangan Terorisme dan Badan Pembinaan Ideologi Pancasila, diharapkan mampu membuat sebuah kurikulum Pendidikan yang dirancang untuk mengacu pada karakteristik Pancasila. Penulisan ini menemukan bahwa peraturan dan dasar hukum kerjasama antar lembaga telah ada dan persiapan landasan teknis kerjasama perlu disiapkan, sehingga tindakan dan hasil kurikulum Pendidikan dengan dasar karakter Pancasila yang berupa generasi muda yang berkarakter Pancasila dapat tercipta.
Jaminan Yang Setara: Mengkalibrasi Kontrak Dan Hukum Waris
Authors: Tedjosaputro Liliana
Published: October 2022

Perkembangan dunia, banyak perusahaan asuransi bekerjasama dengan perbankan dalam penjualan kredit dengan pengambilan asuransi jiwa. Tulisan ini membahas beda asuransi jiwa dengan hibah wasiat/legaat. dan mengkalibrasi hukum kontrak dan hukum waris sebagai jaminan setara.  Metode riset yuridis empiris memakai informasi sekunder selaku informasi utama serta informasi primer selaku informasi pendukung. Hasil penelitian, jaminan yang setara didapat dengan mengkalibrasi hukum kontrak dengan hukum waris sebab dasar asuransi jiwa merupakan kontrak antara pengambil asuransi ataupun pemberi manfaat dengan industri asuransi, jika pemberi manfaat wafat hingga industri asuransi wajib membagikan uang yang diperjanjikan pada penerima manfaat sebab berdasar pada polis asuransi jiwa.  Ketentuan pada pewarisan dalam hukum waris bila pewaris meninggal dunia maka harta warisannya akan jatuh pada ahli waris, Bila warisannya tidak mencukupi maka dapat dilakukan inkorting atau inbreng pada legaat atau hibah yang telah diberikan dan juga memenuhi legitime portie kalau dituntut. Kesimpulan, kalau pewaris itu meninggal dunia dalam keadaan pailit dan penerima manfaat itu juga ahli waris maka kurator kepailitan tidak dapat mengambil uang yang diperjanjikan pada penerima manfaat karena yang dipakai adalah hukum perjanjian (polis) bukanlah hukum waris.
Kebijakan Hukum Pidana Tentang Diversi Terhadap Anak Pelaku Recidive Guna Mencapai Restorative Justice
Authors: Cahyo Rico Nur , Cahyaningtyas Irma
Published: October 2022

Anak sejatinya merupakan generasi penerus suatu bangsa yang wajib memperoleh perlindungan. Perlindungan anak yang berurusan dengan hukum diatur dalam UU SPPA, yaitu melalui upaya diversi dengan pendekatan Restorative Justice. Pada kondisi saat ini, undang-undang tersebut masih terdapat kekosongan norma dalam anak pelaku recidive, hal tersebut bertentangan dengan tujuan perlindungan anak. Tulisan ini membahas bagaimana penyelesaian perkara anak terutama recidive anak dan upaya apa yang dapat dilakukan guna mengefektifkan dan memaksimalkan perlindungan kepada anak. Metode yang dipergunakan yaitu yuridis normatif, spesifikasi penelitian deskriptif analitis, jenis data dengan data sekunder, dan analisis data secara kualitatif. UU SPPA mengatur tentang penyelesaian perkara anak yang berurusan dengan hukum, yaitu menggunakan upaya mediasi penal. Mediasi penal merupakan upaya penyelesaian perkara anak pada saat ini, namun masih terdapat kekurangan yang masih harus dievaluasi kembali. Untuk kedepan diharapkan adanya upaya mediasi non penal guna mencegah sekaligus mengurangi perkara anak terutama recidive, agar terjamin dan terlindungi masa depan anak di Indonesia.
Kajian Hukum Berakhirnya Kontrak Pemborongan Akibat Rechtverwerking atau Pelepasan Hak di Indonesia
Authors: Trisnawati Bakti
Published: October 2022

Perjanjian (Overeenkomst) merupakan suatu peristiwa dimana pihak yang satu berjanji kepada pihak lain untuk melaksanakan suatu hal berdasarkan peristiwa tersebut, lalu timbul hubungan hukum antara kedua belah pihak. Tujuan penelitian ini adalah untuk mengkaji akibat hukum berakhirnya kontrak pemborongan akibat pelepasan hak (Rechtverwerking). Penelitian ini menggunakan metode penelitian hukum normatif. Hasil penelitian ini menunjukan bahwa, didalam kontrak pemborongan mengenai prinsip hubungan hukum antara kedua belah pihak telah dijelaskan pada Kitab Undang-Undang Hukum Perdata, yaitu: Prinsip korelasi tanggung jawab para pihak, Prinsip Ketegasan tanggung jawab pemborong, Prinsip Larangan Perubahan Harga Perjanjian, Prinsip Kebebasan Pemutusan Perjanjian Secara Sepihak. Namun dalam prakteknya ternyata kontrak pemborongan dapat berakhir juga akibat rechtverwerking / pelepasan hak disebabkan karena pemilik bangunan pada saat serah terima bangunan sudah menerima bangunan tersebut dan dia tidak menegur atau mengajukan keberatan akan mutu bahan bangunan yang dipakai, dan dia juga telah menggunakan bangunan itu. Selang beberapa lama mereka baru memutuskan perjanjian dengan mengajukan gugatan.
Kebijakan Corporate Social Responsibility: Investasi Sosial dalam Pengembangan Masyarakat selama Pandemi Covid-19
Authors: Sudirman Lu , Disemadi Hari Sutra
Published: October 2022

Penyebaran Covid-19 mempengaruhi kestabilan ekonomi suatu negara. Indonesia merupakan salah satu negara yang kestabilan ekononominya terganggu akibat penyebaran Covid-19. Maka, dibutuhkan kolaborasi seluruh elemen sebagai upaya bersama dalam proses peningkatan kesejahteraan dan kualitas hidup masyarakat, salah satunya adalah peran perusahaan. Perusahaan dinilai memiliki peran penting dalam pertumbuhan ekonomi serta mengentaskan kemiskinan selama pandemi ini. Maka, penelitian ini bertujuan untuk mengetahui serta mengkaji eksistensi pengaturan CSR di Indonesia dan upaya perusahaan dalam pengembangan masyarakat selama Pandemi Covid-19. Penelitian menggunakan metode penelitian hukum normatif dengan pendekatan konseptual. Hasil penelitian ini menunjukan bahwa di Indonesia pengaturan CSR belum diatur secara utuh sehingga dinilai tidak jelas dan tidak konsisten. Hal ini mengakibatkan kurangnya kepastian hukum sehingga dibutuhkan regulasi yang jelas dan konsisten agar tidak menimbulkan multitafsir atau interpretasi yang berbeda mengenai CSR. Dimasa Pandemi Covid-19 saat ini CSR dapat diimplementasikan oleh perusahaan sebagi upaya pengembangan masyarakat melalui program pemberdayaan. Kebijakan CSR setiap perusahaan tentunya perlu melalui strategi yang telah disesuaikan dengan potensi dan lingkungan masyarakat.
Pembaharuan Kebijakan Hukum Pidana Dalam Upaya Penanggulangan Tindak Pidana Perpajakan
Authors: Virginia Erja Fitria , Soponyono Eko
Published: October 2022

Sejalan dengan “kemajuan ilmu pengetahuan, teknologi informasi, ekonomi, sosial dan politik pemerintah dituntut untuk menciptakan clean governance melalui reformasi Undang-Undang Perpajakan. Hal ini bertujuan agar menciptakan keadilan dan upaya untuk meningkatkan kualitas pelayanan bagi wajib pajak. Selain itu, kemajuan diberbagai bidang juga menimbulkan adanya suatu tindak pidana di bidang perpajakan. Tujuan dari penulisan artikel ini adalah untuk mengkaji kebijakan hukum pidana dalam upaya penanggulangan tindak pidana di bidang perpajakan berdasarkan hukum positif saat ini dan di masa yang akan datang.Pengaturan mengenai tindak pidana di bidang perpajakan diatur dalam Undang-Undang Nomor 28 Tahun 2007 tentang Ketentuan Umum dan Tata Cara Perpajakan jo. Ketentuan-ketentuan umum dalam KUHP yang mengatur mengenai tindak pidana yang dapat menjadi dasar pemidanaan tindak pidana perpajakan. kebijakan hukum pidana“di bidang perpajakan di masa yang akan datang seharusnya sejalan dengan prinsip dalam pidana perpajakan, bahwa sanksi pidana dalam perpajakan adalah bersifat Ultimum Remidium.”
Ide Family Group Conference Dalam Sistem Peradilan Pidana Anak Di Indonesia
Authors: Febriansari Kiki Mahendra , Cahyaningtyas Irma
Published: October 2022

Salah satu upaya pengoptimalan diversi ialah dengan ide pembaharuan melalui Family Group Conference. Family Group Conference adalah model penyelesaian perkara pidana melalui proses pemufakatan bagi anak sebagai pelaku tindak pidana guna menggapai Restorative Justice dalam menyelesaikan masalah anak. Artikel ini membahas  tentang ide pembaharuan family group conference serta sebagai sarana untuk mencapai restorative justice dalam sistem peradilan pidana anak di Indonesia. Ide pembaharuan tersebut dapat dilaksanakan melalui pembaharuan Sistem Peradilan Pidana Anak untuk mengoptimalkan restorative justice yang jauh lebih baik, tidak kaku, dan fleksibel yang berlandaskan nilai Pancasila. Metode yang digunakan yaitu metode yuridis normatif, dengan spesifikasi penelitian deskriptif analitis, artikel ini menunjukkan hasil bahwa Family Group Conference dapat diterapkan dalam sistem peradilan pidana anak sebagai ide pembaharuan guna mencapai restorative justice. Family Group Conference dapat menjadi model penyelesaian sistem peradilan pidana anak di masa yang akan datang dengan melibatkan partisipasi aktif keluarga, lembaga pemerhati masalah anak, dan anggota masyarakat yang terlibat.
Empowering Informal Learning and Soft-Skill Enrichment Through an Arts -based Project of Animation among Secondary School Students
Authors: Khir Roselina , Pawanteh Murina , Lajis Ahmad S. , Stephens John
Published: October 2022

This research aimed to share with educational stake-holders how informal learning through an Arts -based project can contribute to soft-skill enrichment among school learners. The soft skills looked at were based on the 4 C -skills, Creativity, Critical Thinking, Communication and Collaboration. Secondary school students carried out an animation project based on a musical theatre during the Covid -19 pandemic, half of it online, and half through physical meetings. To achieve these objectives, this research used observation, self-reflection and questionnaires to collect data from 13 students and responses from 3 virtual critics. The analysis method used for this research was descriptive analysis. The results showed that specific arts ensemble activity such as creating a performance or animation is able to produce high level of generalized group production skills. The module    can be used as indicators for future arts project collaboration with the 4C’s as the final outcome. These participants believed that an arts-based project had opened up their minds and outlook beyond school exams.
A novel deep learning approach for sickle cell anemia detection in human RBCs using an improved wrapper-based feature selection technique in microscopic blood smear images
Authors: S. Alagu , Ganesan Kavitha , K. Bhoopathy Bagan
Published: October 2022

Sickle Cell Anemia (SCA) is a disorder in Red Blood Cells (RBCs) of human blood. Children under five years and pregnant women are mostly affected by SCA. Early diagnosis of this ailment can save lives. In recent years, the computer aided diagnosis of SCA is preferred to resolve this issue. A novel and effective deep learning approach for identification of sickle cell anemia is proposed in this work. Around nine hundred microscopic images of human red blood cells are obtained from the public database ‘erythrocytes IDB’. All the images are resized uniformly. About 2048 deep features are extracted from the fully connected layer of pre-trained model InceptionV3. These features are further subjected to classification using optimization-based methods. An improved wrapper-based feature selection technique is implemented using Multi- Objective Binary Grey Wolf Optimization (MO-BGWO) approach with KNN and SVM for classification. The detection of sickle cell is also performed using typical InceptionV3 model by using SoftMax layer. It is observed that the performance of the proposed system seems to be high when compared to the classification using the original InceptionV3 model. The results are validated by various evaluation metrics such as accuracy, precision, sensitivity, specificity and F1-score. The SVM classifier yields high accuracy of about 96%. The optimal subset of deep features along with SVM enhances the system performance in the proposed work. Thus, the proposed approach is appropriate for pathologists to take early clinical decisions on detection of sickle cells.
Assessing the vitality of Gombe dialect of Fulfulde: a multi-scale approach
Authors: Adamu Abdulkadir , Yola Abdulkarim Musa
Published: October 2022

Language vitality and endangerment theorizing and research have been focused mainly on whole languages, relegating their individual dialects to the background, on the one hand; and on using single scales in assessing vitality and endangerment, on the other. In this paper, however, we advocate a paradigm shift for more, better successes in this undertaking. Therefore, we aim to examine the degree(s) of vitality and endangerment of Gombe dialect of Fulfulde using multiple evaluative scales, both western and non-western. Prior to placing the dialect on these scales, we collected data from Fulfulde speakers of varied age ranges, all Gombe radio stations and listeners of their Fulfulde programs, using ‘insider’ participant observations, in-depth, semi-structured interviews with a proficiency test component (after which both the respondents and the researchers agreed on the proficiency levels of the former) and online surveys. Analysis of the data reveals that the vitality of this code is better viewed relatively rather than absolutely. Its subsequent placement on the evaluative scales only helps to corroborate this. Finally, while our analysis shows that dialects are just as place-able on these evaluative scales as whole languages are (notwithstanding the hitches characterizing the scales), we argue that, with sustained collective efforts, a dialect-focused evaluative framework is likely to be born in the foreseeable future.
Risk assessment process for the Iraqi petroleum sector
Authors: Abduljabbar Noor Abdulsattar , Breesam Hatem Khaleefah
Published: October 2022

Risk management is important for project success as risks in petroleum projects must be minimized to achieve the goals of production. Risk management composes of planning, identification, analysis, and response, which is an important phase. Controlling risks gains the projects the capability to overcome the uncertainty and thus effectively produce the targeted quantities. In this study, four types of risks have been examined in the oil field, and the Iraqi oil exploration company has been taken as a case study. These four types of risks are operational, financial and administrative, economic and political, and potential risks. The effect of these types has been examined by using a closed-type questionnaire form. The questionnaire form was based on the Likert quintet scale, and it contains 114 risk factors distributed in four groups representing the examined four types of risks. Over 170 questionnaire forms have been distributed in the oil field to engineers, managers, experts, and technicians, and 153 forms have been adopted for the analysis. SPSS software was used to execute the statistical analysis concerning statistical mean and relative important index. The most important factors have been found and then validated by using an assessment checklist. It was found that the most factors affecting operational risks are as follows: the presence of mines and explosives left over from past wars in areas to be explored and the incorrect storage of flammable materials. Regarding the financial and administrative risks, it was found that the existence of financial and administrative corruption in oil companies and the mismanagement by managers or their assistants have the most effect on this type of risk. For the economic and political risks, it was found that the most important factors are the entry of some companies into the blacklist of major economic countries and decreased global market demand for oil. Finally, regarding the potential risks, it was found that the control of terrorist groups over the oil areas and regions is the most significant risk that the Iraqi oil and gas sector may face. In addition, it was concluded that the spread of Coronavirus disease 2019 and other epidemics should be treated as a potential risk because it has a huge effect on global oil prices.
Hemoglobin A1C can differentiate subjects with GCK mutations among patients suspected to have MODY
Authors: Yılmaz Uzman Ceren , Erbaş İbrahim Mert , Giray Bozkaya Özlem , Paketçi Ahu , Çağlayan Ahmet Okay , Abacı Ayhan , Kulalı Melike Ataseven , Böber Ece , Kekilli Arda , Çinleti Tayfun , Erçal Murat Derya , Demir Korcan
Published: October 2022

Objectives

The aim of this study is to determine the clinical and molecular characteristics enabling differential diagnosis in a group of Turkish children clinically diagnosed with MODY and identify the cut-off value of HbA1c, which can distinguish patients with GCK variants from young-onset type 1 and type 2 diabetes.

Methods

The study included 49 patients from 48 unrelated families who were admitted between 2018 and 2020 with a clinical diagnosis of MODY. Clinical and laboratory characteristics of the patients at the time of the diagnosis were obtained from hospital records. Variant analysis of ten MODY genes was performed using targeted next-generation sequencing (NGS) panel and the variants were classified according to American Collage of Medical Genetics and Genomics (ACMG) Standards and Guidelines recommendations.

Results

A total of 14 (28%) pathogenic/likely pathogenic variants were detected among 49 patients. 11 variants in GCK and 3 variants in HNF1A genes were found. We identified four novel variants in GCK gene. Using ROC analysis, we found that best cut-off value of HbA1c at the time of diagnosis for predicting the subjects with a GCK variant among patients suspected to have MODY was 6.95% (sensitivity 90%, specificity 86%, AUC 0.89 [95% CI: 0.783–1]). Most of the cases without GCK variant (33/38 [86%]) had an HbA1c value above this cutoff value. We found that among participants suspected of having MODY, family history, HbA1c at the time of diagnosis, and not using insulin therapy were the most differentiating variables of patients with GCK variants.

Conclusions

Family history, HbA1c at the time of diagnosis, and not receiving insulin therapy were found to be the most distinguishing variables of patients with GCK variants among subjects suspected to have MODY.
A note on commutators of strongly singular Calderón-Zygmund operators
Authors: Zhang Pu , Zhu Xiaomeng
Published: October 2022

In this article, the authors consider the commutators of strongly singular Calderón-Zygmund operator with Lipschitz functions. A sufficient condition is given for the boundedness of the commutators from Lebesgue spaces

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{L}^{p}\left({{\mathbb{R}}}^{n})

to certain Campanato spaces

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.
Performativity of remixed poetry. Computational translations and Digital Humanities
Authors: Nicolau Felix
Published: October 2022

Digital Humanities favours creativity with the help of remixing, hybridization, contamination, and computational translation. An example in point is the book published in 2021 by MARGENTO, Steve Rushton and Taner Murat: Various wanted/Se caută diversuri. Starting from Ovid’s poetic cycle Amores, the authors prove their adroitness in playing with rhythms, prosody, and augmented or compensated translations. Their enterprise is founded on the archetype of dislocation, as the three poets who helped them establish a model for writing/assembling poems, Ovid, Christopher Marlowe, and John Dryden, were ostracized figures. That is why the translations embarked upon in the volume are dislocating and creative. These approaches are tackled with the help of Eugen Coșeriu’s integral linguistics and with Sorin Ciutacu’s enlightening observations on the study of change. The latest enhancements in Digital Humanities have consecrated a second orality and a third textuality, as José Manuel Lucía Megías remarked.
Embedding systems thinking in tertiary chemistry for sustainability
Authors: Pilcher Lynne A.
Published: October 2022

In response to the IUPAC call to introduce systems thinking in tertiary chemistry education, we have developed and implemented two interventions at the first-year undergraduate level: one was designed to integrate systems thinking in first-year organic chemistry using the topic of surfactants and the other in a first-semester service course to engineering students using the stoichiometry of the synthesis of aspirin. We demonstrate how the systems thinking approach in both interventions did not lose the focus of the chemistry content that needed to be covered, exposed students to the concept of systems thinking, started to develop some systems thinking skills, and made a case for the contribution that chemistry can and should make to meet the UN sustainable development goals. Through both the design and the implementation process, it has become clear that introducing systems thinking is complex and it remains a challenge to keep the complexity manageable to avoid cognitive overload. Both interventions leveraged the power of group work to help students deal with the complexity of the topics while also developing participatory competence required for sustainability. The development of systems thinking skills and a capacity to cope with complexity requires multiple opportunities. Infusing syllabus themes that relate to real chemical systems with a systems thinking perspective can provide such an opportunity without compromising chemistry teaching. We believe that skills development should continue throughout the undergraduate chemistry degree to deliver chemistry graduates who can make a difference to global sustainability.
Corrosion resistance of 6061-T6 aluminium alloy and its feasibility of near-surface reinforcements in concrete structure
Authors: Luo Daming , Li Fan , Xing Guohua
Published: October 2022

The durability of concrete structures is often reduced owing to the corrosion of reinforcement in an aggressive environment. Ordinary reinforcement methods, such as wrapping section steel or steel plate, are also vulnerable to corrosion. Using 6061-T6 aluminium alloy as near-surface reinforcement of the concrete structure is a feasible method. In this study, the corrosion resistance of 6061-T6 aluminium alloy bars was studied by simulating the coastal environment, atmospheric environment, and concrete internal environment with chloride solution, simulated acid rain solution, and saturated Ca(OH)2 solution. The corrosion rate of the 6061-T6 aluminium alloy in the above environments was tested using a weight loss method, and its corrosion resistance was evaluated using the metal corrosion resistance classification standard. Based on the electrochemical reaction mechanism, the polarisation properties and AC impedance spectra of steel and 6061-T6 aluminium alloy were compared, and the corrosion resistance mechanisms of steel and the 6061-T6 aluminium alloy in the above corrosive environments were obtained. The results show that the 6061-T6 aluminium alloy has better corrosion resistance than steel bars in chloride and atmospheric environments, with corrosion currents of 0.012 and 0.037 µA·cm−2, and 8-day corrosion rates of 0.051 and 0.031 mm·a−1, respectively. However, owing to the activity of the aluminium alloy, its corrosion resistance in an alkaline environment inside concrete is poor; the corrosion current is 0.22 µA·cm−2 and the 8-day corrosion rate is 16.166 mm·a−1. The research results can provide a reference for applying aluminium alloy bars as external prestressed concrete bars and near-surface steel bars.
Evaluation of wear and corrosion properties of FSWed aluminum alloy plates of AA2020-T4 with heat treatment under different aging periods
Authors: Yunus Mohammed , Alamro Turki
Published: October 2022

Aluminum alloy AA2020 has a greater demand for the high strength-to-weight ratio used in applications like aerospace, naval, and automotive applications because heat treatment produces high strength. Friction stir welding (FSW) is widely employed in forming butt joints of AA2020-T4 using a square profile tool. In this work, the wear characteristics and the corrosion behavior with and without age-hardened treatment are studied and compared. In this work, the wear characteristics and the corrosion behavior with and without age-hardened treatment (after a 1-hour solution treatment of AA2020 alloy at 505°C, quenched in water at ambient temperature) are studied and compared. Age-hardened models with a high aging duration (16–20 h) at 177°C showed a reduction in wear resistance for low spindle speed in contrast to the as-FSWed joints. In the corrosion medium, long aging time heat-treated FSWed joints showed high passivity in a 3.5 wt% NaCl solution. Intergranular and pitting types of corroded surfaces in as-FSWed joints were spotted. 20 h of age-hardened FSWed joints achieved the minimal corrosion rate (CR) and is suggested for moderate wear resistance and good CR. The speed appears to have a greater impact on wear rate than the weld speed and applied load. It is also worth noting that the CR increases by 5% with the increasing spindle speed and falls by 4% with the increasing weld speed.
Заметки к переписке Н. М. Карамзина в контексте сравнительной литературы
Authors: Дуккон Агнеш
Published: October 2022

The Notes to the Correspondence of N. M. Karamzin – In the Context of Comparative Literature. This paper treats the letters of N. M. Karamzin to I. I. Dmitriev, written between 1787 and 1826. The aim of the author is to investigate the connections of private life, literature and history in the correspondence of the two poets and point out the common motifs with the novel of the Hungarian writer, Mór Jókai Freedom under the snow (1879). The novel deals with the revolt of decabrists in 1825, in which the real hictorical figures, like tsar Alexander I and Pushkin, play an important role. The author of the paper comes to the conclusion that the similarities in the characters can be interpreted as the common spiritual attitude of Karamzin and Jókai, and in the other hand, as the Hungarian writer’s great interest in the Russian history and his profound knowledge in that area.
Plantas medicinais utilizadas por hipertensos e diabéticos em um município da Região Sul do Brasil
Authors: Peres Junior Odir Victoria , Ceolin Teila , Timm Bonow Camila , Polino Gomes Marcela , Araújo Fonseca Roberta , Fraga Mercali Laura Mariana
Published: October 2022

Objetivo: conhecer as plantas medicinais utilizadas por hipertensos e/ou diabéticos, residentes na área urbana do município de Herval, Rio Grande do Sul. Métodos: estudo qualitativo realizado no município de Herval, Rio Grande do Sul, com 10 pessoas portadoras de hipertensão e/ou diabetes. A coleta de dados ocorreu em 2016, por meio de entrevista semiestruturada e registro fotográfico. As entrevistas foram analisadas por meio da proposta operativa. Resultados: a maioria dos participantes apresentava idade superior a 60 anos. Foram citadas 26 plantas, sendo oito para o tratamento da hipertensão, cinco para o controle da diabetes e três para ambas as patologias. Conclusão: as plantas medicinais possuem propriedades que auxiliam no cuidado da hipertensão e do diabetes. Destaca-se a importância de dialogar com os usuários sobre as plantas utilizadas, assim como sua valorização, promovendo a união entre o conhecimento popular e científico.
UM PROJETO DE TRADUÇÃO FEMINISTA TRANSNACIONAL E ESTRATÉGIAS ESTRANGEIRIZANTES
Authors: Leivas Waquil Marina
Published: October 2022

Considerando os princípios da Tradutologia Feminista Transnacional segundo os quais se defende intervir nos desiguais fluxos de conhecimento produzidos no mundo por meio da tradução, este trabalho se centra em apresentar um projeto tradutório de uma mulher e de um contexto geopolítico em grande medida desconhecidos no Brasil: a panamenha Melanie Taylor. A partir da tradução para o português de seu conto "El viaje", refletiu-se sobre a aplicação de estratégias tradutórias feministas e estrangeirizantes que, ao mesmo tempo, visibilizam o texto enquanto tradução, valorizando a voz da tradutora, e destacam a alteridade cultural enunciada no texto de partida, contribuindo para a difusão de conhecimento no contexto de chegada.
RELAÇÕES DE EXOTIZAÇÃO E DOMESTICAÇÃO EM TRADUÇÃO
Authors: Cristiane Kahmann Andrea , Antonio de Sousa Alves Daniel , Franco Aixelá Javier
Published: October 2022

Relações de exotização e domesticação em tradução: apresentação ao número especial
Tunable Action Potential Repolarization Governed by Kv3.4 Channels in Dorsal Root Ganglion Neurons
Authors: Alexander Tyler D. , Muqeem Tanziyah , Zhi Lianteng , Tymanskyj Stephen R. , Covarrubias Manuel
Published: October 2022

The Kv3.4 channel regulates action potential (AP) repolarization in nociceptors and excitatory synaptic transmission in the spinal cord. We hypothesize that this is a tunable role governed by protein kinase-C-dependent phosphorylation of the Kv3.4 cytoplasmic N-terminal inactivation domain (NTID) at four nonequivalent sites. However, there is a paucity of causation evidence linking the phosphorylation status of Kv3.4 to the properties of the AP. To establish this link, we used adeno-associated viral vectors to specifically manipulate the expression and the effective phosphorylation status of Kv3.4 in cultured dorsal root ganglion (DRG) neurons from mixed-sex rat embryos at embryonic day 18. These vectors encoded GFP (background control), wild-type (WT) Kv3.4, phosphonull (PN) Kv3.4 mutant (PN = S[8,9,15,21]A), phosphomimic (PM) Kv3.4 mutant (PM = S[8,9,15,21]D), and a Kv3.4 nonconducting dominant-negative (DN) pore mutant (DN = W429F). Following viral infection of the DRG neurons, we evaluated transduction efficiency and Kv3.4 expression and function via fluorescence microscopy and patch clamping. All functional Kv3.4 constructs induced current overexpression with similar voltage dependence of activation. However, whereas Kv3.4-WT and Kv3.4-PN induced fast transient currents, the Kv3.4-PM induced currents exhibiting impaired inactivation. In contrast, the Kv3.4-DN abolished the endogenous Kv3.4 current. Consequently, Kv3.4-DN and Kv3.4-PM produced APs with the longest and shortest durations, respectively, whereas Kv3.4-WT and Kv3.4-PN produced intermediate results. Moreover, the AP widths and maximum rates of AP repolarization from these groups are negatively correlated. We conclude that the expression and effective phosphorylation status of the Kv3.4 NTID confer a tunable mechanism of AP repolarization, which may provide exquisite regulation of pain signaling in DRG neurons.

SIGNIFICANCE STATEMENTThe AP is an all-or-none millisecond-long electrical impulse that encodes information in the frequency and patterns of repetitive firing. However, signaling may also depend on the plasticity and diversity of the AP waveform. For instance, the shape and duration of the AP may regulate nociceptive synaptic transmission between a primary sensory afferent to a secondary neuron in the spinal cord. Here, we used mutants of the Kv3.4 voltage-gated potassium channel to manipulate its expression and effective phosphorylation status in dorsal root ganglion neurons and directly show how the expression and malleable inactivation properties of Kv3.4 govern the AP duration and repolarization rate. These results elucidate a mechanism of neural AP plasticity that may regulate pain signaling.
Monoclinic tungsten trioxide (WO3) thin films using spraying pyrolysis: electrical, structural and stoichiometric ratio at different molarity
Authors:   Laser Science and Technology Branch, University of Technology - Iraq, Baghdad, Iraq, Mohamed F. A. , Salim E. T. ,   Laser Science and Technology Branch, University of Technology - Iraq, Baghdad, Iraq, Hassan A. I. ,   Laser Science and Technology Branch, University of Technology - Iraq, Baghdad, Iraq
Published: October 2022

Chemical spraying pyrolysis technique has used to deposit tungsten oxide on glass substrates with varied concentrations ranging from 50 to 90 mM at the optimum deposition temperature of 350 ͦ C. All films exhibit a monoclinic phase, with highest structural properties at a molar concentration of 80 mM. Miller's plain at (200) was found to be the most dominant in all films. The film has a fibrous network with an increasing diameter with increasing concentration, according to FE-SEM. The EDX revealed that the ratio of W/O at the optimum concentration (80mM) was 2.62, with a stoichiometric of 68.6%. The rate of grain size grew with concentration, whereas the rate of roughness reduced with concentration, according to atomic force microscopy investigations of thin films. The mean electrical conductivity increased gradually with concentration up to 4.176 x10-8 S/cm-1 and subsequently declined to 4.542x 10-10 S/cm-1 , while the activation energy climbed gradually with concentration up to reach 0.298eV before decreasing significantly
Allium sativum extract mediated synthesis of Ag/Zn bimetallic nanostructures for antibacterial application
Authors:   Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia, Balcha E. K. , Marica A. ,   Faculty of Medicine and Pharmacy, Doctoral School of Biomedical Sciences, University of Oradea, P-ta 1 Decembrie 10, 410073 Oradea, Romania, Zeleke T. D. ,   Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia, Murthy H. C. A. ,   Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia, Roy A. ,   Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, India, Ravikumar C. R. ,   Research Centre, Department of Science, East West Institute of Technology, Bangalore 560091, India, Cavalu S. ,   Faculty of Medicine and Pharmacy, Doctoral School of Biomedical Sciences, University of Oradea, P-ta 1 Decembrie 10, 410073 Oradea, Romania, Azad A. K. ,   Faculty of Pharmacy, MAHSA University, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia
Published: October 2022

In this study, Ag and Ag/Zn bimetallic nanostructures (BMNs) were synthesized via the green route by using the extracts of Allium Sativum L plant. The obtained structures were characterized for structural, morphological and optical features by using X-ray diffraction (XRD), electron microcopy (SEM) and UV-vis spectroscopy. The XRD results confirmed cubic crystal structure for the Ag/Zn BMNs with average crystallite size 17.47 nm, while for Ag Ns an average crystallite size of 9.31 nm was noticed. UV-vis spectra of Ag and Ag/Zn BMNs showed absorbance maxima at 402 nm and 360 nm, respectively, while the morphological featured recorded by SEM showed irregular shape for both structures. The antibacterial activities of Ag and Ag/Zn bimetallic structures were investigated against selected bacterial strains, the maximum inhibition being recorded against P. aeruginosa. In addition, the antibacterial effect was found to increase with increased concentration of both Ag and Ag/Zn nanostructures, while a superior effect was noticed for Ag Ns compared to Ag/Zn BMNs for both the gram-negative and gram-positive bacterial strains.
Fabrication of Ag/TiO2 nanotube array as active electrocatalyst for the hydrogen evolution reaction
Authors:   aUniversity POLITEHNICA of Bucharest, Faculty of Applied Chemistry and Materials Science, 1-7 Polizu, 011061, Bucharest, Romania, Mîndroiu M. , Popescu M. ,   National Institute for Research and Development in Microtechnologies, 126A, Erou Iancu Nicolae Street, 077190, Bucharest, Romania
Published: October 2022

Silver nanoparticles (Ag NPs) were fabricated onto titanium substrates with and without titania nanotubes arrays (TiO2 NTs) using electrochemical and chemical techniques, respectively, to create nanostructured electrocatalysts for the hydrogen evolution reaction (HER). The active surface area of the catalyst is determined by the Ag NPs' structure and the presence of TiO2 nanotubes on the titanium substrate. The electrocatalytic activity was improved by chemically synthesizing Ag NPs onto a titanium electrode that had been precoated with TiO2 nanotubes.
Electrochemical preparation method of titanium dioxide on FTO
Authors:   Lab. VTRS, Faculty of Technology, Univ. El-Oued, El oued 39000, Algeria, Rahal F. , Kamarchou A. ,   Laboratory of pollution and waste treatement , University Kasdi merbah Ouargla, Ouargla 30000, Algeria, Berchi A. ,   Laboratory of Energy and electrochemistry of solid Process Engineering U.F.A. University of Sétif, Algeria, Abdi D. ,   Laboratory of Energy and electrochemistry of solid Process Engineering U.F.A. University of Sétif, Algeria, Kemerchou I. ,   Department of Mechanical engineering, Faculty of Applied Science, University of Ouargla, 3000, Algeria
Published: October 2022

Cathodic electrodeposition of aqueous peroxo-titanium complex solution on fluorine doped tin dioxide (FTO) covered glass produced nanocrystalline amorphous and crystalline titanium dioxide. X-rays were used to examine the surface structures, which shows that heat treatment made a gradual crystallization of the deposits to the anatase form meanwhile the non-heated deposits present amorphous phase. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) and atomic force microscopy (AFM) permit to investigate the morphological aspect of the deposits, which display a good adherence and a nanoparticulate grain size. The UV-Visible spectroscopic investigation technique reveals the better transparency aspect of the annealed films than the non-heated deposits. Ac impedance spectroscopy confirms the electrical conductivity of both deposits with more important activity for the non-heated deposits.
Insulin resistance and racial disparities in breast cancer prognosis: a multi-center cohort study
Authors: Gallagher Emily J , Greco Giampaolo , Lin Sylvia , Yagnik Radhi , Feldman Sheldon M , Port Elisa , Friedman Neil B , Boolbol Susan K , Killelea Brigid , Pilewskie Melissa , Choi Lydia , LeRoith Derek , Bickell Nina A
Published: October 2022

The survival for breast cancer (BC) is improving but remains lower in Black women than White women. A number of factors potentially drive the racial differences in BC outcomes. The aim of our study was to determine if insulin resistance (defined as homeostatic model assessment for insulin resistance (HOMA-IR)), mediated part of the relationship between race and BC prognosis (defined by the improved Nottingham prognostic index (iNPI)). We performed a cross-sectional study, recruiting self-identified Black and White women with newly diagnosed primary invasive BC from 10 US hospitals between March 2013 and February 2020. Survey, anthropometric, laboratory, and tumor pathology data were gathered, and we compared the results between Black and White women. We calculated HOMA-IR as well as iNPI scores and examined the associations between HOMA-IR and iNPI. After exclusions, the final cohort was 1206: 911 (76%) White and 295 (24%) Black women. Metabolic syndrome and insulin resistance were more common in Black than White women. Black women had less lobular BC, three times more triple-negative BC, and BCs with higher stage and iNPI scores than White women (P < 0.001 for all comparisons). Fewer Black women had BC genetic testing performed. HOMA-IR mediated part of the association between race and iNPI, particularly in BCs that carried a good prognosis and were hormone receptor (HR)-positive. Higher HOMA-IR scores were associated with progesterone receptor-negative BC in White women but not Black women. Overall, our results suggest that HOMA-IR contributes to the racial disparities in BC outcomes, particularly for women with HR-positive BCs.
Characterization and identification of wooden rice bucket made in 1860s
Authors: Tu Xin Wei , Liu Xin You , Varodi Anca Maria
Published: October 2022

This study presents the results of a comprehensive investigation of a wooden rice bucket made in the 1860s. Macroscopy aspects and microscopic structure were conducted to identify the wood species. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) were also adopted to investigate the degradation degree of the rice bucket compared with a new wood sample from the same species. The results of the microscopic identification concluded that the rice bucket was made of Chinese fir (Cunninghamia lanceolata). The XRD pattern indicated that the crystallinity degree of cellulose in the wooden rice bucket decreased to 33.2% from 38.8% (new wood). The FTIR spectra revealed that natural ageing resulted in the degradation of cellulose and hemicellulose, and the change of lignin was not obvious.