bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening in female patients for HPV and STI for early diagnosis of cervical cancer
Authors: Parasnis Ketki , Palve Tushar , Fatemi Sakina , Narvekar Rutuja , Miskin Sneha , Bendale Rucha
Published: December 2023

Background: High-risk human papillomaviruses (HPV) infection has been the most common sexually transmitted infection worldwide. Moreover, it is a necessary factor for the development of cervical cancer. Several studies have been carried out that screen HPV and other sexually transmitted infections (STI)s occurring in patients at the same time. Timely screening can help early diagnosis of pre-cancerous lesions and assist in prompt treatment to reduce mortality in such patients. The objective of the present study was to screen women for the presence of high-risk HPV (hrHPV) for the early diagnosis of cervical cancer. Some women were additionally screened for STIs. We also aimed to establish an association between the presence of HPV and STI.
Methods: A total of 40 women aged 20-67 years participated in this study. Cervical and or vaginal swabs were collected in liquid-based cytology containers. The samples were tested for fourteen HPV genotypes by USFDA-approved Cobas HPV test. Out of these 40 women 26 were also tested for STI panel.
Results: All women participants were screened for hr-HPV. A total 65% of the study population underwent both the HPV test and the STI test. 7.5% of total women were positive for hrHPV. 30.76% of women tested positive for Ureaplasma and Gardnerella vaginalis in the STI panel. Some women also showed simultaneous presence of STI and HrHPV.
Conclusions: The results of this study will help in better and early diagnosis of women at risk of cervical cancer. The detection of HPV and STI present simultaneously can further help in establishing the role of these two conditions in the development of cervical cancer. Such studies are an encouragement to the HPV elimination programme and vaccination drive that has taken an impetus in recent times in India.
Comparative study of vitamin D3 levels in polycystic ovarian syndrome vs non-polycystic ovarian females
Authors: Sachdeva Manvi , Goel Kashika , Rai Meenu , Kukreja Srishti
Published: December 2023

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and has a strong genetic component with a prevalence of 6–10% in the general population. Metabolic disturbances are common in women suffering from PCOS: 30–40% have impaired glucose tolerance and IR with compensatory hyperinsulinemia, and as many as 10% will have type 2 diabetes mellitus by their fourth decade. Recently, vitamin D deficiency has been proposed as the possible missing link between IR and PCOS. Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences.  This study aims to estimate vitamin D3 levels in patients of polycystic ovarian disease and compare it with non PCOS females and to study correlation between Vitamin D3 levels and polycystic ovarian syndrome.
Methods: The present patient population case control study was carried out in Department of Obstetrics and Gynaecology of Jaipur Golden Hospital diagnosed involving cases of PCOS and controls of non PCOS (48 each) by random sampling method from September 2019 to June 2021. History, general examination, systemic examination and Vitamin D levels was taken for each patient.
Results: Mean vitamin D value of cases was 14.57±6.86 ng/ml and that in controls was 29.31±6.53 ng/ml. When we compared the mean vitamin D value of both the groups, there was statistically significant difference found between the two groups. . We found significant negative correlation found between vitamin D value with age and BMI.
Conclusions: Hypovitaminosis D is very common in PCOS patients and exacerbates the metabolic abnormalities. It is essential to screen all the PCOS patients for 25OHD deficiency and institute appropriate replacement therapy to prevent the adverse consequences.
Functional outcome of arthroscopic labral repair in adults for traumatic shoulder instability: a prospective study
Authors: Chaudhary Vijay , Dave Tirthraj , Nalge Swapnil , Menon Hari , Shah Kalgi , Shah Ishan , Chaudhary Kishor , Parmar Aakash , Patel Dixit
Published: December 2023

Background: Anterior shoulder instability is often treated either by open procedure or arthroscopic method. present study to assess the functional outcome of the patients with recurrent dislocation of shoulder with Bankart lesion, treated with arthroscopic stabilization to evaluate shoulder function with labral tear and after repair of labral tear, to study epidemiology of labral tear and to study epidemiology of associated lesions.
Methods: Prospective study in the 25 consented patients admitted in the orthopaedics department in new civil hospital Surat with different shoulder injury after IEC approval. Statistical analyses done in MS excel.
Results: Mean age at time of first dislocation was 30 year and most (50%) were of 20-30 years. Most patients were males (92%). 84% of the cases, the dominant side is involved, right shoulder. Number of episodes of recurrent dislocation prior to surgery averaged 5 times. most common mechanism was Accidental fall (48%) followed by sports (32%), RTA (20%). Association of Hill-Sachs lesions was 80% with labral-tear secured with extra suture anchor. Preoperative parameters; number of dislocations, chronicity, reduction method do not have any significance on outcome. Rowe-score improved from 40.2% Preoperatively to 89.8% postoperatively at 12 weeks. 80% of patients is having excellent outcome.
Conclusions: Arthroscopic Bankart’s repair is gold standard for labral tear due to recurrent shoulder dislocation which led to short surgery time, less intraoperative and postoperative complications, increased shoulder function among patients. Associated Hill Sach’s lesion should be repaired for better functional outcome.
Malunited supracondylar femur fracture in haemophilia A: a case report on evaluation and management
Authors: Sharma Swati , Kumar Amit , Sharma Sanjay
Published: December 2023

Haemophilia is a rare inherited X-linked bleeding disorder associated with various levels of coagulation factor VIII (type A) or IX (type B) deficit. Hemophilic patients can be affected by trauma and fractures just like the general population. But due to their bleeding disorder, such patients need specific multidisciplinary management, from the emergency room to the operating theatre, in order to limit severe complications. The goal of modern fracture treatment is to obtain an optimal outcome, with the patient's return to full activity as soon as possible. If a fracture is correctly treated in a haemophilic patient, it will progress to consolidation in a similar time-frame to fractures occurring in the general population. Worldwide, there are only a few specialized orthopaedic centres dedicated to the management of hemophilia. Management of supracondylar femur fracture in patients with haemophilia is no different from general population if an adequate haemostasis is achieved. The purpose of this paper is to report our experience on the supracondylar fracture of the femur in hemophilia by a multidisciplinary team at a single institution.
Recurrent myxoid liposarcoma of thigh
Authors: K.B. Vismaya , Rashid Rihan
Published: December 2023

We are presenting the case of a 78 year old man who presented to our out-patient clinic with a history of a recurrent mass over the anteromedial aspect of the left thigh. The aim of this case report is to study the clinical, radiological findings, diagnosis and surgical management of a well differentiated liposarcoma.
An interesting case of post dengue Guillain Barre syndrome
Authors: Kumar Vivek , Dang Naresh , Lodhi Preeti
Published: December 2023

Neurological manifestations of dengue fever are seen in around 0.5-6% patients. Post dengue Gullain Barre Syndrome (GBS) is uncommon and only few cases of GBS have been causally linked to serologically confirmed dengue illness. We report a case of 51-year-old male with acute onset flaccid paralysis of all 4 limbs within 1 week of dengue fever, which worsened rapidly despite early initiation of IVIG. Patient became quadriplegic with bilateral LMN facial paralysis, needing intubation and ventilation. When patient did not improve even after 3 weeks of IVIG therapy, plasmapheresis was started and 5 exchanges were given over 10 days following which patient showed significant recovery and became ambulatory and independent at 6 months. In our case 2 dose of IVIG was not considered as his serum IgG levels were raised.

Role of plasmapheresis in patients of GBS, responding poorly to IVIG needs further evaluation.

GBS is an uncommon neurological manifestation of dengue fever. Role of plasmapheresis in patients who respond poorly to IVIG needs to be considered.
Therapeutic efficacy of rivastigmine in Alzheimer’s disease
Authors: Prasad S Durga , Patel Tirath
Published: December 2023

A 72-year-old White male complained of memory loss, trouble recalling names and events, and a regular-duty deterioration. Hypertension, type 2 diabetes, and hyperlipidemia characterized the patient’s history. He never drank alcohol or used illicit drugs. His mother had Alzheimer’s, and his father had a stroke. The patient’s physical examination was unremarkable except for a 20- out-of-30 Mini-Mental State Examination (MMSE) score, suggesting mild cognitive impairment. Rivastigmine 1.5 mg twice a day was started, with an eight-week escalation to 6 mg twice daily. He was given rivastigmine and memantine to slow cognitive impairment. Treatment efficacy and side effects were extensively examined. This report highlights the therapeutic efficacy of rivastigmine in improving cognitive function in patients with Alzheimer’s disease. The improvement in cognitive function and absence of significant adverse effects suggest that the treatment approach was effective in managing the patient's Alzheimer's disease.
Empowering human potential and fostering values: A vision for private higher education in Malaysia
Authors: Jaya Joana , Vasudevan Asokan , Nagaraj Sriganeshvarun , Hashim Mohd Haizra , Tunjungsari Hetty Karunia
Published: December 2023

The purpose of this study is to investigate the empowerment of human potential and how it fosters values in Private Higher Education in Malaysia. Due to the high demand for postsecondary education, the private higher education sector is experiencing fierce competition, making strategic communication more crucial. The study employs a quantitative approach with a sample size of 24 respondents, namely academic and non-academic staff from private higher education institutions in Malaysia, where a statistical analysis was performed using SMART-PLS. The study employed a random sampling method to gather samples from private higher education institutions in Malaysia. The results of the analysis indicated that talent does not influence strategic communication positively. The β value result of this variable is 0.767, the t value is 1.730, and the p-value of 0.084 did not meet the benchmark where the t value is less than 1.96 and the p-value is less than 0.05. The results of human values also do not influence strategic communication positively. The β value is 0.007, the t value is 0.021, and the p-value of 0.983 again did not meet the benchmark for the t value and the p-value. The findings of this study pave the way for future research on strategic communication in private higher education institutions and provide practitioners with actionable mechanisms to enhance this area of practice. This research concludes that strategic communication plays a crucial role in the private higher education sector and that talent and human values are crucial to achieving successful communication strategies.
Development of enzyme-linked immunosorbent assay (ELISA) based on covalent immobilization of antibody on plate for measurement of digoxin
Authors: Enayati Hamidesadat , Mohammadnejad Javad , Nikfarjam Alireza
Published: December 2023

Objectives: The aim of this study was to design an enzyme immunoassay based on a modified ELISA with high sensitivity for detecting digoxin.
Methods: The first step in development involved the conjugation of digoxin to the HRP (Horse Radish Peroxidase) enzyme via sodium metaperiodate oxidation. Surface modification, and thus assay modification, was achieved by the covalent immobilization of an anti-digoxin monoclonal antibody on a functional plate using 3-ATPES (3-aminopropyltriethoxysilane).
Results: The developed ELISA demonstrated superior sensitivity (0.026μg/ml) and lower variability in measurements repeated throughout a day, compared to a conventional ELISA (0.051μg/ml). This assay detected the exact amount of digoxin. The sensitivity and specificity of the modified ELISA surpassed other methods, and measurements were performed within a few hours.
Conclusion: An efficient ELISA kit was produced, characterized by its affordability, ease of learning, and absence of a hand-washing step.
Genistein in combination with Chlorogenic acid ameliorates insulin resistance and oxidative stress in skeletal muscle of high-fat diet fed mice
Authors: Goodarzi Golnaz , Yadollahi Mitra , Tehrani Sadra Samavarchi , Meshkani Reza
Published: December 2023

Objectives: Increasing evidence has demonstrated that oxidative stress plays a significant role in the pathogenesis of muscle insulin resistance. The beneficial impacts of genistein (GEN) and chlorogenic acid (CGA) on insulin resistance have already been revealed. However, their combined effects on skeletal muscle oxidative stress and insulin resistance have not been completely understood. The aim of the present study was to determine the effect of GEN in combination with CGA on skeletal muscle insulin resistance in high-fat diet (HFD) fed C57BL/6 mice.
Methods: C57BL/6 male mice were fed an HFD for 15 weeks. The mice were then divided into five groups: standard chow diet (SCD), HFD, HFD + GEN, HFD + CGA, and HFD + GEN + CGA for 10 weeks.
Results: The findings indicated that single treatment with GEN or CGA, and with a stronger effect of GEN+CGA combined treatment, decreased body weight gain and improved glucose intolerance. Moreover, following treatment with GEN and CGA alone or in combination with further effect, the level of plasma and muscle triglyceride (TG) were reduced. Furthermore, the combination therapy of GEN and CGA with greater efficacy than the single treatments, could decrease several oxidative stress markers in the skeletal muscle. Treatment with GEN and CGA alone or in combination could increase the expression of NF-E2–related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P): Quinone Oxidoreductase 1 (NQO1).
Conclusion: The data of this study suggest that the combination of GEN and CGA might ameliorate insulin resistance and reduce oxidative stress in the skeletal muscle of mice fed HFD.
Clinical Manifestations and Outcomes of COVID-19 in Diabetes Mellitus People, Yazd, Iran-2021
Authors: Mehrabbeik Akram , Mirzaei Mohsen , Askari Maryam , Sahami Mohamad Ali , Minoosepehr Mozhgan , Namiranian Nasim
Published: December 2023

Objective: Diabetes mellitus is reported to be the third most prevalent comorbidity with COVID-19, after cardio‐cerebrovascular disease and hypertension. Furthermore, diabetes increases the likelihood of admission to the hospital and intensive care unit and death from COVID-19. The aim of the present study was to compare the clinical manifestations and outcomes of COVID-19 in diabetic versus non-diabetic inpatients.
Materials and Methods: The medical records of 6525 patients with definitive diagnosis of COVID-19 were obtained from the reference COVID-19 diagnosis laboratory from January to July 2021 in Yazd, Iran. Patients were investigated for data on onset, clinical history, and fatality rate. COVID-19-related death was defined as positive RT-PCR in at least one of three nasal samples. Data were analysed using SPSS 24.
Results: Among inpatients, 21.2% were diabetic. The mean ages of diabetic and non-diabetic patients were 64.45 (±13.87) and 52.98 (±20.36) years, respectively. Diabetics were more likely to be admitted to the intensive care unit (6.8% vs. 5%, P= 0.02) and the fatality rate was higher among them than non-diabetics (22.6% vs. 12%, P< 0.001). In diabetics, the mean age of non-survivors was lower than that of survivors (62.57 vs. 70.48, P= 0.0001) and the frequency of death was higher among men than women (53% vs. 47.5%, P= 0.045). Generally, diabetes has the strongest association with COVID-19 death (P= 0.0001).
Conclusion: Diabetic patients experience more adverse outcomes because of COVID-19. These findings indicate the need for special attention in relation to prevention treatment against COVID-19 in patients with diabetes.
Impact of High-Intensity Interval Training on GLP-1R/ PKBα Axis in Pancreatic Tissue of Diabetes Rats Induced by High-Fat Diet and STZ
Authors: Behkar Mehdi , Eizadi Mojtaba , Sedaghaty Saeid , Kazemzadeh Yaser , Moslehi Motahareh
Published: December 2023

Objective: Apart from hormonal factors and oxidative stress, insulin synthesis is strongly dependent on transcription factors in the pancreas. The aim of the present study was to assess the impact of high-intensity interval training (HIIT) on genes affecting insulin synthesis in diabetic obese rats.
Materials and Methods: Type 2 diabetes (T2D) was induced by a 6-week high-fat diet (HFD) and intraperitoneal injection of streptozotocin (25 mg /kg) in 14 male Wistar rats (10 week old, 220±10 g). Rats with fasting glucose levels between 400 and 150 were considered T2D. The diabetic rats were randomly assigned to exercise (HIIT: 6 weeks/5 sessions weekly, n= 7) or control (n= 7) groups. Forty-eight hours after the intervention, fasting GLP-1R and PKBα gene expression in pancreatic tissue and plasma insulin and glucose levels were compared between the groups. Data were compared by independent t-test used to compare variables, version 22 between groups. A P< 0.05 was considered significant.
Results: HIIT led to significant increase in PKBα gene expression (P: 0.001) and insulin (P: 0.031) and decreases in glucose concentration (P: 0.001) compared with the control group. No change was observed in the GLP-1R gene expression response to HIIT (P: 0.093).
Conclusion: HIIT is associated with increased serum insulin levels in T2D obese rats. Despite no change in GLP-1R, this improvement is probably rooted in increased expression PKBα in pancreas in response to this type of exercise training
Effectiveness of Acceptance and Commitment Group Therapy with the Islamic Approach to Reduce Anxiety and Depression in Type II Diabetes People in Yazd
Authors: Hakimian Mohammad Mehdi , Sedrpoushan Najmeh , Shahreza Farid Abolhassani
Published: December 2023

Objective: The purpose of this study was to investigate the effectiveness of acceptance and commitment based group therapy (ACT) with the Islamic approach to reduce anxiety and depression in patients with type II diabetes referent to the Yazd Diabetes Research Center.
Materials and Methods: The study method was the semi experimental. Forty diabetic patients were simple randomly divided into two equal experimental and control groups. The study was done in the patients referent to the Yazd diabetes center (n= 5000), using a purposeful sampling method. So, all of the patients did completed the beck anxiety (BAI) and depression (BDI-II) questionnaire for diabetic patients. Then, the experimental group received ACT with an Islamic approach every other week during 16 weeks and 120 minutes for each time, and the control group continued their normal plan. The population of both groups performed the anxiety (BAI) and depression (BDI-II) questionnaire again after performing the instructional plan.
Results: In this research, the covariance analysis test was used to analyze the results. The findings of the research showed that ACT with an Islamic approach effects on the anxiety (P: 0.001) and depression (P: 0.001) in type II diabetes people.
Conclusion: The results showed that ACT with Islamic approach is effective on reducing anxiety rate and depression of type 2 diabetic people. Scores of post-test confirmed the effect of treatment method ACT with Islamic approach on reducing of anxiety and depression rate.
Effectiveness of Acceptance and Commitment Based Group Therapy with the Islamic Approach on Diabetes Control and Increasing Self-Care Behaviors in Patients with Type II Diabetes in Yazd province.
Authors: Hakimian Mohammad Mehdi , Sedrpoushan Najmeh , Shahreza Farid Abolhassani
Published: December 2023

Objective: The purpose of this study was to investigate the effectiveness of acceptance and commitment based group therapy (ACT) with the Islamic approach to diabetes control, increasing self-care behaviors in patients with type II diabetes mellitus (T2DM) referent to the Yazd Diabetes Research Center.
Materials and Methods: The study method was semi experimental with control group. For this purpose, 40 diabetic patients were randomly divided into two experimental and control groups. The study was in Yazd diabetes research center. The purposeful sampling method was done. So, all of the patients did the A1C hemoglobin test, and completed the self-care questionnaire for diabetic patients (SDSCA). Then, the experimental group received ACT with an Islamic approach during 16 weeks. The population of both groups performed the A1C Hemoglobin test and completed the self-care questionnaire again after performing the instructional plan. In this research, the covariance analysis test was done to analyze the results.
Results: The findings of the research showed that ACT group therapy with an Islamic approach effects on HbA1c decreasing (P: 0.001) and self-care behaviors improvement (P: 0.001) in T2DM patients.
Conclusion: This study showed that the treatment group based on commitment resulted in a significant reduction of HbA1 and a significant increase in self-care activities in patients with T2DM.
Health impacts assessment and economic costs of implementing three scenarios of the clean air act in one of the largest middle east cities (2017-2026); An AirQ+ modeling
Authors: Panji Mozhgan , Shahsavani Abbas , Rashidi Yousef , Hashemi Nazari Seyed Saeid , Mohseni Bandpei Anoushiravan , Kermani Majid , Namvar Zahra
Published: December 2023

Introduction: This study aimed to assess the health impacts and economic costs of implementing the scenarios of decommissioning end-of-life cars and motorcycles and equipping buses with soot filters in Tehran, one of the largest cities in the Middle East, over a period of ten years (2017-2026) using the AIRQ+ model.
Materials and methods: To start, the emission weights of Particulate matter (PM2.5) emitted from the vehicles mentioned in the scenarios were extracted from the Comprehensive National Action Plan for Reducing Air Pollution. Then the concentrations of PM2.5 were calculated using AERMOD. Finally, the AIRQ+ model was used to calculate the health effects of the scenarios over ten years.
Results: The results indicated that implementing the total of three scenarios during ten years led to a reduction in mortality rates due to all causes, Chronic Obstructive Pulmonary Disease (COPD), lung cancer, Acute Lower Respiratory tract Infection (ALRI), Ischemic Heart Disease (IHD), and stroke by 14.89%, 6.16%, 31.51%, 19.5%, 16.5%, and 17.38%, respectively. In addition, decommissioning end-of- life cars and motorcycles separately led to a 6.75% and 6.53% reduction in deaths from all causes, 2.54% and 2.46% from COPD, 18.40% and 18.01% from lung cancer, 11.16% and 11% from ALRI, 12.82% and 12.69% from IHD, and 12.12% and 12.96% from stroke.
Conclusion: The results indicate that the implementation of these scenarios during ten years has positive effects on reducing deaths attributed by PM2.5 particles, but due to population growth, it has no effect on reducing economic costs.
Indoor air quality monitoring in metropolitan city Lahore, using handheld devices
Authors: Muneeb Iqbal Muhammad , Shafiq Muhammad
Published: December 2023

Introduction: Outdoor air pollution has been considered the primary issue by scientists and environmentalists for decades. With the advancement of technology, the activities of human are shifting from outdoor to indoor, urging researchers to investigate the indoor environment. Theerefore, the focus of this study is to examine indoor air quality in the metropolitan of Lahore.

Materials and methods: The Temtop M2000C and Temtop H3 Laser monitors were used to collect data on Particulate Matter (PM), Carbon dioxide (CO2) concentration, Total Volatile Organic Compounds (TVOC), and formaldehyde (HCHO). The concentration of air pollutants in nine indoor areas was measured for a specified time interval. The values of particulate matter are measured to find the impact of the outdoor environment on the indoor environment.

Results: The maximum average values of the particulate matter PM2.5 and PM10 were 488.6 μg/m3 and 737.2 6 μg/m3, respectively, which reduced drastically after the rain to 219 μg/m3 and 340 μg/m3, respectively. The maximum values of PM2.5 and PM1 0 during coal burning outside the room were 997.6 μg/m3 and 999.9 μg/m3, respectively, far higher than the values during normal conditions. TVOC and HCHO were found within the prescribed limits.

Conclusion: The outcomes of this study established a deep impact of the outdoor environment on the indoor environment and recommend air purifiers to reduce the level of pollutants in the indoor environment.
Indoor air microbial quality in medical emergency of an Algerian hospital
Authors: Djadi Amina , Benadda Samia , Agouillal Farid , Kaced Amel , Cherifi Nabila , Lemou Abdelkader , Ouakli Nabila Ait , Ladji Riad
Published: December 2023

Introduction: In this work, we target the analysis and the characterization of bioaerosols species present in medical emergency of north Algerian hospital, were we consider in four operating rooms, two preoperative and resuscitation rooms.
Materials and methods: Passive technique was applied for the collection of bacterial and fungal samples in indoor air, for three days from 16 to 18 January 2018. Two techniques were then chosen for the bacterial identification, the Analytical Profile Index (API) system and Matrix Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS).
Results: It has been found that fungal contamination was highest in neurosurgery block, 103 CFU/m3, whereas the highest bacterial contamination, 2645 CFU/m3, was noted in postoperative room. The most predominant identified bacteria were Gram-positive cocci.
Conclusion: The high contamination in bioaerosols and the types of bacteria identified in the premises studied increase the risk of contracting a nosocomial infection, hence the importance of daily disinfection and sterilization of hospitals area in order to reduce bioaerosols dangerous effects on human health.
Effectiveness of chemical road dust suppressants on paved roads of Pimpri Chinchwad
Authors: Shaikh Sahila , Mane Sachin , More Ashok
Published: December 2023

Introduction: Currently, reducing road dust emissions is a serious problem for safe and environment-protective transportation, leading to Particulate Matter (PM) limit violations and high population exposures to dust containing poisonous metals and mineral particles. Nowadays chemical road dust suppressants are being employed more frequently as a viable remedy to reduce roadside dust emissions.
Materials and methods: Two seasons winter and summer were selected for the study and during which, typically 3 types of roads as per average traffic density and land-use category identified in the city of Pimpri-Chinchwad were sprayed. Dry samples were taken on day one from a 1 m2 area using a portable vacuum cleaner that was run for 8 to 10 min each. Similarly, samples were collected in the same area after 5-10 min after spraying with Calcium Chloride (CaCl ) and Magnesium Chloride (MgCl ). Also, the second set of 2 samples was collected after 24 h of chemical applied.
Results: Maximum reduction in silt loading occurred i.e., 99.73% on the application of 30 g/m2 of CaCl . Reduction observed in emission factor of PM2.5 was 97.78% and in the case of PM10 it was 97.59%. While increase in average particle size was observed up to 27.88 µm.
Conclusion: Both the suppressant efficient in suppressing the road dust but the day 1 result shows more dust suppression as compared to the day 2 dust suppression also as per the dust loading CaCl2 is a better dust suppressant than MgCl2.
A Review of New Anticancer Nanoformulations based on Cyanobacteria and Microalgae and its Application in Medical Sciences, Dentistry and Pharmacy
Authors: Nowruzi Bahareh , Hashemizaveh Nazaninsadat
Published: December 2023

Introduction: Nanoparticles are widely used in various fields of pharmaceuticals, dentistry, medicine, biology and materials engineering due to their special features, including high surface-to-volume ratio, homogeneous particle size distribution, high stability, and ease of production. The formation of coatings is driven by the existence of numerous pathogenic bacteria that give rise to diverse infections, weaken the immune system in humans, and pose significant risks in areas such as food packaging, synthetic textiles, medical and dental equipment, as well as public health concerns related to drinking water and sewage treatment. The formation of coatings is driven by the existence of numerous pathogenic bacteria that give rise to diverse infections, weaken the immune system in humans, and pose significant risks in areas such as food packaging, synthetic textiles, medical and dental equipment, as well as public health concerns related to drinking water and sewage treatment. More than 50% of marine cyanobacteria can potentially be used to extract bioactive substances and are known to be very effective in killing cancer by inducing apoptotic death. In this review article, recent researches in the field of drugs or compounds based on microalgae and also their biomedical applications are emphasized. Likewise, recent advances in the field of discovering anticancer compounds, commercialization of microalgae anticancer drugs, production of nanoformulated drugs based on microalgae, and production of formulations for high loading drug delivery and its application in medical sciences, pharmacy and dentistry are emphasized.
Conclusion: The development and improvement of nanoparticle biosynthesis processes using cyanobacteria may leads to the discovery of new biogenic nanoparticles with unique properties that can significantly increase the effectiveness of medical treatments and reduce side effects.
Covid-19: Investigation of Important Mutations and their Effect on Vaccine Efficacy
Authors: Ataei Yasaman Sadat
Published: December 2023

Introduction: Unknown pneumonia caused by acute respiratory syndrome coronavirus-2 (nCoV/SARS-CoV-2 2019) started in Wuhan, China. Compared to other corona virus infections, this variant is more contagious and its genome encodes all the proteins necessary for infection and reproduction. The most important structural proteins of this virus are spike glycoprotein, envelope protein, membrane protein and nucleocapsid protein. Mutations accrued to these proteins, especially to the spike protein, played an important role in the creation of new variants. For example, E484K, L452R, S477N and F486V mutations are among the important mutations that can be considered when designing vaccines based on spike protein in the future. These mutations lead to the variants with new and different characteristics, and for this reason, the vaccine production process for this virus has faced many challenges. Various companies all over the world entered the competition to make vaccines, and finally, by producing different types of vaccines, this disease was controlled tolerably. But new mutations in the future could still lead to diverse variants with resistance to existing vaccines, and for this reason, societies and governments would face serious challenges.
Conclusion: Based on these interpretations, possible emergence of new variants in the future could not be denied. However, prediction of the location of these mutations in not possible though. as a result, it is important to conduct research on the emerging variants, to be prepared for new possible challenges in the future.
Comparison of the Antimicrobial and Antioxidant Effects of Oleuropein Extracted from Arbequina Olive Leaves with the Extracts of its Leaf and Fruit
Authors: Babaei Masomeh , Hassan Jalal , Koohi Mohammad Kazem , Ghasemzadeh Mohammad Ali
Published: December 2023

Introduction: Olive leaf is an evergreen plant and enriched in phenolic compounds and antioxidants. Oleuropein is the most common type of phenolic compounds can found in Olive leaves. The aim of this study was to compare the antimicrobial and antioxidant effects of Oleuropein extracted from olive leaf with the extracts from its leaf and fruit.
Methods: The type of study was experimental and after ethanol extraction from olive leaf and fruit, oleuropein was isolated from the leaf extract. Antimicrobial effects of Oleuropein obtained from olive fruit and leaf extracts against Staphylococcus saprophyticus and Pseudomonas aeruginosa bacteria were determined using minimum inhibitory concentration (MIC) method. Amounts of phenolic compounds were derived by the Folin-Ciocalteu assay and the antioxidant effects were determined by the 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) free radical inhibition method. SPSS version 16 software was used for statistical calculations, Excel program used to draw graphs and one-way ANOVA was used to evaluate the effect of the intervention.
Results: Oleuropein was extracted from olive leaf in the amount of 14% with a purity of 70%. The highest and lowest amount of phenolic compounds and the antimicrobial and antioxidant effects were observed for Oleuropein obtained from olive leaf and olive fruit extracts, respectively. The amount of oleuropein phenolic compounds was equal to 879.16 (µg GAE/g), its MIC against S. saprophyticus and P.aeruginosa bacteria was equal to 3.25 and 12.5 mg/ml, respectively. Its antioxidant activity was equal to 8.59 µg/ml.
Conclusion: In the present study, oleuropein was extracted from olive leaves and the study showed that the amount of oleuropein in the Spanish Arbican variety was obtained with the highest value of 14%. According to the results of antimicrobial activity and antioxidant, it can be concluded that olive leaf extract and extracted oleuropein have the potential to increase and improve the performance of preservatives and antioxidants.
Manastırlı Mehmed Rifat Bey’in Cevâhir-i Çihâr Yâr ve Emsâl-i Kibâr Adlı Tercümesinde İlk Üç Halifeye Ait Hikmetli Sözler
Authors: SAİTOĞLU Rıdvan
Published: December 2023

Manastırlı Mehmed Rifat (ö. 1325/1907) tarafından kaleme alınan Cevâhir-i Çihâr Yâr ve Emsâl-i Kibâr adlı eser, dört halifeye ait yüz veciz söz ihtiva etmektedir. Eser, Reşîdüddîn Vatvat’ın (ö. 578/1182) Tühefetü’s-sıddîk ile’s-sıddîk min Kelâmi Ebî Bekr es-Sıddîk, Efdalü’l-hitâb min Kelâmi Ömer bin el-Hattâb, Ünsü’l-lefhân min Kelâmi Osmân bin Affân, Matlûbu Külli Tâlib min Kelâmi Emîri’l-mü’minîn Alî bin Ebî Tâlib, adlı eserlerinin ya da genel isimlendirme ile Şerh-i Sad Kelime-i Çehâr Yâr-i Güzin’inin bir tercümesidir. Bu çalışma Rifat Bey’in söz konusu eserinde daha önce incelenen Hz. Ali’ye ait vecizelerin dışında kalan ilk üç halifeye ait vecizelerin incelenerek literatüre kazandırılmasını hedeflemektedir.
A deterministic inventory model for deteriorating products with shortages and price dependent demand rate
Authors: Singh Dhrub Kumar
Published: December 2023

Purpose of the study: The proposed model shows a deterministic approach of the inventory management in which the rate of the deterioration of the inventory commodities is proportional to time, demand rate is a function of selling price and inventory holding cost both, ordering cost and deterioration rate are all function of time. Here shortages are allowed during the lead time and completely backlogged. The optimum replenishment policy is to be determined which minimizes the total cost. The rate of deterioration has been considered as non-instantaneous and that follows the two parameters Weibull distribution. In the proposed model we aim to find optimal value of the inventory level to minimize the total effective cost.

Methodology: The optimal solution will have to be obtained by using Mathematica Software and has been illustrated using a numerical example.

Main Findings: Since lowering the selling price would result in increase in purchase of items by the customers, hence the selling price is the major criteria to determine their buying capacity.

Applications of this study: If researchers go on taking several kinds of variable costs etc., then hopefully they may find a new area of study in their research.
Seksualność zapośredniczona przez technologię w świecie postępującej indywidualizacji
Authors: Mańkowska Katarzyna
Published: December 2023

Praktyki seksualne, sposoby ich realizacji oraz rola, jaką pełniły w kształtowaniu się relacji międzyludzkich ulegały zmianom na przestrzeni lat. Współcześnie znaczący wpływ na kształt życia seksualnego ludzi ma kultura popularna, a wraz z nią postępująca indywidualizacja. Niebagatelne znaczenie może mieć również rozwój kultury konsumpcyjnej, wszechobecne utowarowienie, hedonizacja społeczeństwa, dążenie do maksymalizacji przeżyć, cyfryzacja oraz rozkwit otaczających ludzi symulowanych przestrzeni. Czynniki te stają się motorem przemian życia społecznego w niemal każdym jego aspekcie. Ponadto możemy obserwować intensywny rozwój nowych technologii. Nowoczesne produkty wychodzą naprzeciw zmieniającym się potrzebom i ograniczeniom współczesnego życia, również w sferze praktyk seksualnych. Znajdują one swoje miejsce nie tylko w życiu erotycznym par, ale również w życiu indywidualnym jednostek. Realizacja potrzeb seksualnych, przez wieki związana z interakcją z drugim człowiekiem, zaczyna więc być elementem samorealizacji jednostki, w której rolę drugiego człowieka pełni technologia. Warto zadać sobie pytanie, jaką rolę te czynniki będą pełniły w przemianach życia seksualnego ludzi.
Better Migrants, Worse Migrants: Young, Educated Poles Look at New Incomers to Poland
Authors: Nowicka Ewa , Łodziński Sławomir
Published: December 2023

This article concerns select aspects of social perceptions and categorizations of foreigners settling in Poland. The core of this work is an analysis of a series of qualitative interviews conducted with young, educated residents of Warsaw. Herein the authors draw attention to a significant change in the consciousness of Polish society: a recognition of the permanent presence of migrants in Poland as well as discernment of the sociocultural problems associated with that presence. In the eyes of our interlocutors, the past two decades have been a time in which the attitude of Poles towards incoming aliens has shifted. Influencing opinions have been personal or familial experiences of emigration, particularly after the 2004 accession of Poland into the European Union. Also affecting attitudes have been an immigration wave from Ukraine as well as the tangible consequences of the 2015 migrant crisis. On the one hand, all these factors together have caused Poland to be seen today as not only an emigration, but also an immigration country. On the other hand, these have also provoked a conscious classification of various categories of migrants with regards to their geographic and cultural background along with the roles they might possibly fill in this country.
Cellulase and chitinase production by Fusarium oxysporum f.sp. cubense race 1 in submerged culture
Authors: Hernández-Melchor Dulce Jazmín , Ferrera-Cerrato Ronald , García-Ávila Clemente de Jesús , Alarcón Alejandro
Published: December 2023

Fusarium has the capability to produce hydrolytic enzymes that can be used in the food and alcohol industries to break down natural organic compounds. This work studied the ability of Fusarium oxysporum f. sp. cubense race 1 (FocR1) to produce cellulases and chitinases enzymes in submerged culture using different carbon sources. Five strains of FocR1 (CNRF-MIC17188, CNRF-MIC17189, CNRF-MIC17190, CNRF-MIC17191, and CNRF-MIC17192) were used in submerged culture for the degradation of three substrates [filter paper, newspaper, and chitin (Sigma®)], from where the radial growth rate (RGr) and the quantitative analysis of enzyme activities (FPase, CMCase and chitinase) were evaluated. The RGr of the five FocR1 strains oscillated in a range of 0.043 to 0.051 cm h-1. At 7 and 14 days, the five FocR1 strains produced cellulases and chitinases using the three substrates. Based on the statistical analysis, the strains CNRF-MIC17191 and CNRF-MIC17192 showed best results about enzymatic activities. The five strains of FocR1 can be exploited as a commercial source of cellulases and chitinases, as well as potential candidates for bioconverting complex C-sources for further utilization in industrial processes.
Содействие образовательных организаций трудоустройству обучающихся и выпускников с ОВЗ и инвалидностью: региональный аспект
Authors: Копалкина Е.Г.
Published: December 2023

Актуальность определяется низким уровнем трудоустройства выпускников с ОВЗ и инвалидностью, в то время как увеличивается их численность в образовательных организациях среднего и высшего образования. Методы: сравнительный анализ, анализ статистических данных, контент-анализ. Цель: оценка содействия образовательных организаций Иркутской области трудоустройству обучающихся и выпускников с инвалидностью. Результаты: проанализированы статистическая информация о численности инвалидов-студентов, обучающихся по программам среднего профессионального и высшего образования за 2017–2022 учебные годы, показатели деятельности вузов в сфере содействия трудоустройству выпускников с инвалидностью в России и Иркутской области (наличие программы содействия трудоустройству выпускников с инвалидностью, проведение структурными подразделениями вузов мероприятий по содействию трудоустройству обучающихся лиц с инвалидностью, наличие программы постдипломного сопровождения выпускников с инвалидностью), численность выпускников иркутских вузов с инвалидностью, трудоустроившихся в течение календарного года за 2020–2022 гг.; описаны результаты контент-анализа официальных сайтов шести иркутских вузов; определены основные проблемы содействия трудоустройству лиц с инвалидностью и ОВЗ в современных условиях. Выводы: практически во всех образовательных организациях Иркутской области выделены структурные подразделения, занимающиеся вопросами трудоустройства; интернет-страницы данных структурных подразделений информационно насыщены различными карьерными новостями и мероприятиями, ссылками на полезные методические материалы и сервисы, все вузы подключены к цифровой платформе «Факультетус.ру», но информации о результатах содействия трудоустройству студентов и выпускников недостаточно и она совсем отсутствует в отношении лиц с ОВЗ и инвалидностью.
Цифровая трансформация хозяйственных систем: возможности и риски социально-экономического развития (в печати)
Authors: Харитонова Елена , Черемисина Татьяна
Published: December 2023

Актуальность темы связана с неоднозначностью и противоречивостью современной трансформации хозяйственных систем, выраженной в цифровизации и виртуализации экономических, социальных и политических сфер жизни общества. Проблематику виртуализации и цифровизации хозяйственной деятельности затрагивали такие известные ученые, как Д. Белл, Дж.К. Гэлбрейт, М. Кастельс, Э. Тоффлер и многие другие. Вместе с тем в настоящее время сложились две основные концепции цифровой трансформации национальных хозяйственных систем и мировой хозяйственной системы: Новая нормальность Клауса Шваба (западная концепция), Система социального кредита (китайская концепция). Цель: раскрыть дуалистическую природу цифровой трансформации хозяйственных систем, показать возможности и риски для социально-экономического развития и роста. Методы: сравнительный и компаративный анализ основных концепций цифровой трансформации хозяйственных систем, статистический анализ. Результаты: возможны два основных варианта цифровой трансформации хозяйственных систем. Первый вариант предполагает на основе сетевого взаимодействия выработать прозрачный механизм принятия решений государственной властью, что подразумевает подконтрольность власти гражданскому обществу. Такое внедрение цифровых технологий в модель государственного управления будет способствовать расширению границ человеческих возможностей и решению социально-экономических проблем в сторону повышения устойчивости хозяйственных систем. И наоборот, цифровые технологии содействуют усилению надзорных функций государства над обществом, выводят из-под контроля гражданского общества принятие решений государственной властью. В последнем случае применение цифровых технологий будет способствовать повышению неустойчивости хозяйственных систем и развитию дисбалансов в различных сферах жизнедеятельности. Выводы: цифровая трансформация хозяйственных систем должна быть направлена на повышение прозрачности государственных решений, развитие гражданского общества через сетевое взаимодействие, сокращение социального неравенства и дисбалансов на рынке труда. Такая направленность цифровой трансформации, на наш взгляд, будет способствовать переходу хозяйственных систем к устойчивому социально-экономическому развитию и росту.
Historical Study of the System of Social Structure of Hadramaut Arab Descendants in Surakarta
Authors: Ediyono Suryo , Ahmad Alif Al Hilal , Mujahidin Muhammad Farkhan , Malik Abdul , Jazuli Ahmad
Published: December 2023

Research on historical studies on the social structure of the Hadramaut Arab descent community in Surakarta in the 21st century. The Hadramaut descent community grows and develops which has specific social stratification in their life that is continuous from the past, present, to the future. The study of the ancestry of the Hadramaut Arab community in Surakarta was initiated from their grandparents to being inherited by their great-grandchildren. The process of cultural adaptation and acculturation that they carry out has changed and has survived until now. The historical approach to this research is people of Arab descent using descriptive qualitative methods and interviews with Arabs in Surakarta. As a result, the people of Hadramaut descent have developed from the land of their birth and were brought down to the overseas lands where they live in Surakarta for generations. Starting from the Sayyid group, tribe, middle class, to helpers.
Nilai-nilai Tasawuf dalam Kumpulan Puisi Karya Kahlil Gibran
Authors: Pundi Baladaya Nyimas , Apriyanti Apriyanti , Hidayat Rahmat
Published: December 2023

Penelitian ini bertujuan mengkaji lebih dalam nilai-nilai tasawuf dalam kumpulan puisi karya Kahlil Gibran. Hal ini dikarenakan puisi-puisi Kahlil Gibran diduga kuat mengandung nilai-nilai tasawuf meskipun ia bukan seorang muslim. Penelitian ini merupakan penelitian kepustakaan (Libarry Research). Sumber data dalam penelitian berupa primer dan sekunder. Data primer diambil dari tiga puisi Kahlil Gibran dalam buku yang berjudul Setitis Air Mata Seulas Senyum. Sementara data sekunder meliputi dokumentasi berupa buku dan artikel yang berkaitan dengan penelitian. Pengumpulan data dilakukan dengan cara mendokumentasi karya-karya Kahlil Gibran serta berbagai rujukan referensi lainnya. Adapun analisisnya menggunakan metode analisis pesan atau isi yang terkandung dalam puisi-puisi Kahlil Gibran. Hasil dari penelitan ini menunjukkan bahwa ketiga puisi Kahlil Gibran mengandung dua karakteristik yaitu tasawuf akhlaqi dan falsafi. Hal ini diperkuat lagi dengan ditemukannya sembilan nilai-nilai tasawuf di dalamnya. Nilai-nilai tasawuf tersebut adalah mahabbah, zikir, syukur, tafakur, ridho, taubat, tawakal, ikhtiar, dan ittihad.