bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektifitas Kompres Daun Kol (Brassica Oleracea) Terhadap Pengurangan Pembengkakan Payudara Pada Ibu Post Partum di RSUD Syekh Yusuf Gowa Tahun 2019
Authors: Alhidayah  , Muzayyana  , Rika Handayani
Published: January 2023

Pembengkakan payudara merupakan salah satu masalah dalam proses menyusui yang sering dialami ibu postpartum. Di Indonesia angka kejadian pembengkakan 55% dari seluruh ibu postpartum. Salah satu cara untuk mengurangi pembengkakan payudara yaitu dengan melakukan kompres daun kol. Hal ini efektif karena kubis mempunyai sifat antibiotik dan anti-inflamasi karena kandungan sinigrin (Allylisothiocyanate), rapine, minyak mustard, magnesium, dan sulfur yang dapat membantu memperlebar pembuluh darah kapiler, sehingga meningkatkan aliran darah untuk keluar masuk dari daerah tersebut, dan memungkinkan tubuh untuk menyerap kembali cairan yang terbendung dalam payudara tersebut. Penelitian ini bertujuan melakukan efektifitas kompres daun kol terhadap pengurangan pembengkakan payudara pada ibu post partum. Disamping itu untuk mengetahui pembengkakan pada payudara sebelum dan sesudah dilakukan kompres daun kol. Penelitian ini menggunakan metode deskriptif analitik. Penelitian ini dilakukan pada ibu postpartum yang mengalami pembengkakan payudara. Pembengkakan payudara diukur menggunakan skala engorgement menurut Hill dan Humenick dalam whittlestone denagn menggunakan Uji Paired T Test. Setelah melakukan perlakuan pada 30 orang, menunjukkan bahwa efektivitas pemberian kompres daun kubis (brassica oleracea) terhadap skala pembengkakan payudara pada ibu post partum dapat dilihat dari penurunan pembengkakan payudara sebelum diberikan kompres daun kubis (brassica oleracea) yaitu skala 5, sesudah diberikan kompres daun kubis (brassica oleracea) pembengkakan payudara menjadi skala 2 dengan p-value 0,000 ( = 0,05). Kompres daun kol (brassica oleracea) dapat digunakan sebagai terapi untuk menurunkan skala pembengkakan dan mencegah terjadinya pembengkakan payudara pada ibu post partum.
Sistem Absensi Fingerprint Berbasis Arduino dengan Data Penyimpanan di Micro SD
Authors: Pauzan Muh , Yanti Indri
Published: January 2023

Pola yang ada pada jari bersifat unik, pola tersebut dinamakan biometrik. Biometrik digunakan pada metode absensi fingerprint. Penelitian tentang absensi dengan fingerprint baru sebatas pengolahan data absensi tanpa dibuat alat fingerprintnya yang layak pakai. Oleh karena itu dibuat alat absensi dengan metode fingerprint berbasis Arduino yang lebih baik. Jika penelitian-penelitian sebelumnya menggunakan database dan EEPROM di mikrokontroler untuk penyimpanan data absensinya, pada penelitian ini micro SD digunakan untuk penyimpanan data. Tahapan penelitian dimulai dari studi literatur, kemudian perancangan perangkat keras, lalu perancangan perangkat lunak. Setelah alat jadi, dilakukan ujicoba pada alat untuk menganalisis performanya. Dilibatkan 30 responden, masing-masing melakukan scan ibu jari dan telunjuk. Berdasarkan uji jumlah percobaan, ibu jari dan telunjuk memiliki rata-rata jumlah percobaan 1,70 dan 2,73 berturut-turut. Pada uji waktu respon, telunjuk lebih baik dengan waktu rata-rata 2,39 detik berbanding 2,79 detik untuk ibu jari. Pengguna sebaiknya melakukan scan minimal selama 2 detik supaya dapat dideteksi alat.
Analisis Postur Kerja dengan Metode REBA untuk Mengurangi Risiko Cedera Pada Perawat di Bagian Triage dan Rawat Inap Rs. X
Authors: Tutu Christien Gloria
Published: January 2023

Perawat merupakan pekerjaan yang memiliki risiko tinggi untuk mengalami musculoskeletal disorders (MSDs) karena pekerjaan mereka yang menuntut secara fisik. Musculoskeletal disorders (MSDs) merupakan suatu kondisi gangguan otot yang dapat mempengaruhi sistem gerak seperti otot, tulang, sendi dan jaringan ikat (tendon dan ligamen) sehingga kondisi tersebut dapat mengurangi kemampuan dalam bekerja dan partisipasi dalam kehidupan sosial. Work-related musculoskeletal disorders (WRMSDs) mencakup berbagai disfungsi yang terjadi di tempat kerja, yang mempengaruhi otot, saraf, persendian, tendon, tulang rawan, dan cakram tulang belakang. Gangguan musculoskeletal (otot rangka) adalah masalah utama di seluruh dunia. Dalam survei terpisah yang dilakukan pada tahun 2015 di 35 negara Eropa, sebanyak 43% responden menunjukkan bahwa mereka menderita sakit punggung dalam 12 bulan sebelumnya, sementara 42% melaporkan nyeri di leher atau ekstremitas atas pada saat yang sama. Salah satu yang mempengaruhi WRMSDs adalah faktor fisik yang meliputi beban kerja fisik seperti kekuatan, postur tubuh, gerakan berulang dan patient handling. Tujuan penelitian ini adalah untuk menganalisis postur  kerja untuk mengurangi risiko MSDs pada perawat  di bagian Triage dan rawat inap rumah sakit X. Penelitian ini merupakan penelitian observasional dengan menggunakan metode Rapid Entire Body Assessment (REBA). Data didapatkan dengan cara pengukuran sudut postur kerja perawat dengan bantuan foto/video. Berdasarkan pengukuran, perawat paling banyak berada pada level resiko sedang (Skor REBA 6) sebanyak 5 perawat atau 62,5% , kemudian diikuti perawat dengan level resiko tinggi (Skor REBA 10) sebanyak 2 orang atau  25% dan sisanya berada pada level resiko rendah (Skor REBA 2) yakni 1 orang atau 12,5%. Hal ini dapat disimpulkan perawat  berada dalam kondisi tidak sesuai dengan postur kerja yang baik karena skor menunjukan perlu dilakukan tindakan secepatnya. Penelitian ini diharapkan dapat sebagai usulan untuk mengurangi gangguan musculoskeletal kerja menjadi lebih rendah.
Peran Public Relations terhadap Informasi yang Diberikan pada Pasien Rawat Jalan Rsud Dr. M.Yunus Bengkulu
Authors: Novega Novega , Miranda Tenike Gita , Darmawansyah Darmawansyah , Faisal Faisal
Published: January 2023

Kepercayaan dan citra yang baik di mata masyarakat merupakan salah satu yang terpenting bagi eksistensi sebuah perusahaan. Komunikasi merupakan aktivitas dasar manusia,melalui komunikasi manusia dapat saling berhubungan satu sama lain baik dalam kehidupan sehari-hari di rumah tangga tempat kerja, pasar, masyarakat, atau dimanapun manusia berada. Tidak ada manusia yang tidak terlibat dalam komunikasi. Begitu pentingnya komunkasi dalam kehidupan manusia, dan harus diakui bahwa manusia tidak akan bisa hidup tanpa komunikasi. Tujuan penelitian ini adalah untuk mengetahui sejauh mana peran Public Relations dalam memberikan  informasi kepada pasien rawat jalan  di RSUD. dr. M. Yunus Bengkulu. Metode analisis yang digunakan dalam penelitian ini adalah Univariat dan Bivariat, dengan pendekatan cross sectional. Berdasarkan hasil analisis regresi sederhana terlihat bahwa nilai t hitung untuk variabel peran Public Relations adalah sebesar 9,544 dengan signifikansi (p) = 0,00. Nilai p tersebut < α = 0,05, maka  dapat disimpulan Public Relations mempunyai pengaruh  dalam menjalin hubungan untuk menciptakan kepuasan pelangan. Diharapkan penelitian ini dapat dijadikan tambahan pengetahuan bagi penelitian lain, serta sebagai inspirasi untuk melakukan penelitian lebih lanjut tentang Public Relations, dengan penambahan variable penelitian serta dengan metode, desain dan analisis yang berbeda.
Assessment of the scope of activities for sustainable development in the cement industry in Poland with the use of multi-dimensional comparative analysis
Authors: Łapińska Justyna , Escher Iwona , Kądzielawski Grzegorz , Brzustewicz Paweł
Published: January 2023

The article uses the linear ordering method, which falls under the multi-dimensional comparative analysis methods, to assess the scope of activities for sustainable development carried out by cement industry companies operating in Poland. This assessment was based on the structure of the synthetic measure [Qi], which included three diagnostic variables: (i) the scope of environmental and social activities communicated by the company, (ii) the number of published reports in CSRinfo, (iii) company size measured by its market share. The analysis allowed for the identifi cation of leaders in the fi eld of communicated activities that are part of the activities undertaken for sustainable development. They are primarily the largest entities of the cement industry in Poland, which are part of global capital groups.
The ability of clay-cement hydraulic binders to accumulate aliphatic and aromatic hydrocarbons
Authors: Stempkowska Agata
Published: January 2023

Environmental pollution by oil derivatives is one of the most important ecological problems. The penetration of insuffi ciently treated refi nery-petrochemical wastewater into lands, open water reservoirs, arable lands, as well as failures and accidents involving petroleum products, can cause serious consequences resulting from the highly toxic and carcinogenic nature of these substances. The article presents the possibilities of clay and cement binders application to reduce the migration of organic pollutants from heavily contaminated soils. The conducted research showed that in the case of heavily contaminated soils (e.g. from the Glasgow waste landfi ll) the penetration of aromatic and aliphatic hydrocarbons can be signifi cantly reduced. The part of aliphatic hydrocarbons, that migrated into the penetrating solutions during whole measurements time, did not exceed the standard requirements.
Routes of thaumasite formation and ways for its prevention
Authors: Hanaa Youssef Ghorab , Mohamed Mohamed Kamal , Mohamed Sahar Kamal
Published: January 2023

The thaumasite was obtained using two routes: 1) from the exposure of Portland limestone cement pastes, with 30% limestone, to 4% magnesium sulfate solution for 3 months at 7°C, 2) through the carbonation of an ettringite–sodium silicate mix at 7°C, followed by the rise of pH with lime. The phases formed were examined by XRD, infrared spectroscopy, and scanning electron microscopy. The thaumasite after 2 months of exposure of the limestone cement to sulfate solution was formed. It is prevented by the addition of specific chemicals that reduce calcium and sulfate ions. The prevention is confirmed by microstructure analysis and compressive strength measurement. The mechanism of thaumasite formation is explained by the formation of an intermediate phase composed of a carbonated silica gel, which incorporates relicts of the decomposed ettringite. This phase transforms to thaumasite through the liquid phase pH rise by lime. The results support previous literature published as early as 2003 and suggested the formation of an intermediate phase which was the thaumasite, the product of sulfate attack. The present work was defi ning the nature of this phase. This phase was not detected in the fi rst route of the Portland limestone cement system because of the rapid rate of lime supply, from the alite hydrolysis.
The effect of the strengthening of AAC masonry walls using FRCM system
Authors: Drobiec Łukasz , Jasiński Radosław , Mazur Wojciech , Jonkiel Remigiusz
Published: January 2023

This paper describes results from testing the tensile strength of compressed masonry walls strengthened with fiber-reinforced cement matrix [FRCM] system on one side, both sides, or without any strengthening. Test models were prepared from masonry units made of autoclaved aerated concrete SOLBET OPTIMAL 4/600. Walls were built with a ready-mixed mortar for thin layer joints of class M5, without fi lling head joints. PBO fi bre grids embedded in a mineral matrix were used as superfi cial strengthening. Lateral surfaces of masonry walls were strengthened with ready-mixed mortar PBO-MX GOLD MASONRY with embedded grid PBO--MESH GOLD 22/22. Then, the surface layer of ready-mix mortar PBO-MX GOLD MASONRY was applied. The used superfi cial strengthening provided an additional strengthening of the cracked models and their safer behaviour after failure.
Preliminary studies on the effect of core density on plasterboard core strength
Authors: Gajski Jakub , Foltyńska Katarzyna , Bogobowicz Agnieszka , Wieteska Marcin , Lech Ryszard
Published: January 2023

The paper discusses the statistical analysis of the effect of changes in plasterboard core density on the mechanical strength of the core. ANOVA and linear regression were used for the analysis of the results obtained. Gypsum core samples, fabricated manually in molds, and formed continuously on the production line were analysed. The analysis shows that statistically significant changes in the gypsum core density do not always entail statistically significant changes in core strength. There is also a statistically significant, moderate correlation between core strength and core density.
The effect of hydraulic road binders and cement with diamidoamine lactate additive on the compressive strength and freeze-thaw resistance of cohesive soils
Authors: Węgliński Szymon
Published: January 2023

Cohesive soils are very often found in the soil subbase. In order to be a fully-fl edged building subbase, they must be improved. A popular way to improve is to stabilise with binders. In addition to common cement, mixtures of Portland clinker, ash, slag and additives, known as hydraulic road binders, are used. Standard binders allow for increased compressive strength, but do not provide the expected frost resistance that should protect the road structure from frost damage. In the paper the use of a hydrophobic additive of organic origin, produced from natural raw materials – vegetable and animal fats is proposed to reduce water absorption into the stabilised layer, providing improved compression strength and frost resistance of the layer. The addition of diamidoamine lactate to the soil–cement mixtures increased their compressive strength 3 to 8 times, for samples containing 7% binder and 2 to 2.5 times for samples containing 9%, in relation to standard binders.
Application of experimental setup for the thermal conductivity measurement for searching novel environmental material solutions used in construction
Authors: Prałat Karol , Grabowski Mirosław , Majewski Łukasz
Published: January 2023

The presented work includes experimental data on the infl uence of lightweight filler on the thermal conductivity of λ gypsum. In this research, cenospheres were used. Cenospheres were added in the amount of 10% in respect to the mass of gypsum. To measure thermal conductivity, a non-stationary method was used based on the “hot wire method”. A decrease of thermal conductivity and density with added lightweight filler was observed because of microstructure modifications of the gypsum product. Additional microscopic images of the fractures of the modifi ed gypsum were made.
Retraction Notice to: The influence of Al2O3 nanoparticles on the properties of traditional concrete with ground granulated blastfurnace slag as binder
Authors: Nazari Ali , Riahi Shadi , Khalaj Gholamreza , Khalaj Mohammad Javad
Published: January 2023

By the decision of the Editor-in-Chief, article (1) has been withdrawn from Issue 6 Volume 16 (2011) of the Cement Wapno Beton journal. The withdrawn article contains content borrowed without citation, e.g. from Jo et al. (2). The presented cement composition is iden-tical to the cement composition presented in the work of Givi et al. (3). Also, some images were reused, from other paper submitted at a similar time (4) claiming, that they present different material.We would like to apologize to the Readers of Cement Wapno Beton for this situation. We assure You that the Editorial Board makes every effort to avoid such situations. The authors did not respond to messages regarding the withdrawal of the article sent to them by the Editorial Of ce.
Utilization of ground waste glass cullet in the industrial production of precast concrete elements
Authors: Gołek Łukasz , Szudek Wojciech , Łój Grzegorz
Published: January 2023

In the study, a field trial was carried out to evaluate the applicability of ground waste glass cullet as a binder component, in the industrial production of precast concrete elements. The influence of glass cullet addition on the properties of fresh and hardened concretes was compared to siliceous fly ash. Moreover, the effects of a partial substitution of the natural aggregate with recycled concrete and expanded clay aggregate were determined. The compressive strength of concretes, in which 25% of cement was substituted with ground waste glass cullet, was even 20% higher compared to elements with an analogous addition of siliceous fly ash. Over 56 days, no drops in strength related to the harmful effects of the alkali-silica reaction were observed. Replacing half of the natural aggregate with graded recycled concrete aggregate, allowed to lower the thermal conductivity of the walls by approx. 10%, with no negative impact on the compressive strength of precast elements. However, a decrease in the consistency of fresh mix was observed after 30 minutes. Replacing the 2÷8 mm gravel with the same fraction of expanded clay resulted in an approx. 18% decrease in thermal conductivity, while maintaining satisfactory mechanical properties. It was concluded that ground waste glass cullet can be successfully used as a fly ash replacement in the production of precast concrete elements.
Nanosilica role in concrete containing iron oxides aggregates and boron carbide as a shield against gamma rays
Authors: Safamehr Majid , Izadinia Mohsen , Hashemi Sayed , Koohestani Saeideh
Published: January 2023

Two families of heavy concrete were investigated in this project, the first containing hematite and the second magnetite aggregates. Boron carbide also replaced cement in mass of 2.5, 5 and 10%. Once again, in these compounds the content of cement was reduced by 5% and replaced by nanosilica. Such parameters as compressive strength, ultrasonic pulse velocity and density were investigated, and the specimens were irradiated with cobalt 60, to quantify the linear attenuation coefficient. Using iron ore aggregate, especially magnetite, was advantageous for all the above-mentioned parameters, while the opposite was true, when boron carbide was added to the mix. The addition of nanosilica compensated the decrease in compressive strength of concrete due to the presence of boron carbide, but reduced the linear attenuation coefficient by about 4%. However, the properties of the mixes containing boron carbide and nanosilica, were always better than those of conventional concretes. To quantify the linear attenuation coefficient, Monte Carlo simulations were performed, and their results turned out to be in good agreement with those obtained by the experimental measurements.
Mechanical properties of magnesium phosphate cement incorporating basalt fibers
Authors: Pehlivan Ahmet
Published: January 2023

In this experimental study, the effect of basalt fibers on the mechanical properties of magnesium phosphate cement [MPC] was investigated. Compressive strength, splitting tensile strength, flexural strength and modulus of elasticity, were introduced. It was observed that mechanical properties were significantly enhanced with the addition of silica fume, especially splitting tensile and flexural strength were enhanced with the increase of basalt fibers. However, for mixtures without silica fume addition, high content of fibers adversely affected the mechanical properties. Silica fume addition was found to be significant in increasing the bonding mechanism between basalt fibers and the MPC matrix. Thus, combined usage of silica fume and basalt fibers was found to be effective. A molar ratio of magnesia to ammonium dihydrogen phosphate of 8 was observed to have better results with respect to a molar ratio of 6, however, this distinction was not very apparent, when silica fume was added to both mixtures.
“The Silence of Forms” – liberated concrete matter in a sculpture
Authors: Banaszek Michał
Published: January 2023

Although the application of concrete in the visual arts is not as wide as in the construction industry, it reflects diverse artistic attitudes and expectations regarding this material. We come across its use mostly in public space, being a natural space for concrete. When it comes to small-scale sculptures exhibited in art galleries, concrete is not found that often. Sculpture is a vastfield dominated from one hand by traditional materials such as bronze, stone, ceramics, but also open to spatial and material experiments. The articles presents a number of concrete use cases in the creative way: its method, the output, and the conclusions. The aim of the project was to depart from the typical architectural function of concrete and to present it as the flexible one that enables one to take advantage of its expressive features. As a result, a set of works called “The Silence of Forms” was created, which was fully or partially presented in some art exhibitions in the years 2019-2021.
Importance of zinc in Portland cement production
Authors: Kurdowski Wiesław , Zajd Paweł
Published: January 2023

In laboratory experiments, we found the unexpected influence of zinc addition, which was the acceleration of the Portland cement setting. This untypical cement behaviour was caused by the addition of anhydrite II as the setting time regulator, by its producer. Anhydrite II dissolves very slowly and the sulphate ions concentration in the paste of the hydrating cement, was very low. However, zinc was soluted very quickly and its hydroxide precipitated on the surface of C 3 A crystals, limiting the formation of the continuous ettringite layer. Thus, ettringite is formed in the free areas in the solution, linking the cement grains, with the formation of the quick “ettringite” setting. Ettringite precipitated in the free areas within the solution, binds to the cement grains and causes the ‘quick’ setting of ettringite. However, the alite crystals remain continuously covered by the amorphous layer of Zn(OH) 2 , and under this condition the induction period with water reaction of this phase remains hang-up. The elongation of this period is increasing with the increase in the addition of zinc
Short glass fiber reinforced polymer concrete with addition of waste cathode-ray tube (CRT) glass
Authors: Smoleń Jakub , Tomaszewska Klaudia , Junak Grzegorz , Kozioł Mateusz
Published: January 2023

This paper describes the use of CRT glass waste for the production of polymer concrete. The CRT glass was subjected to a multistage mechanical disintegration process, in a way that allowed obtaining grains smaller than 2 mm. A set of hybrid reinforced polymer concrete was produced by using: ground CRT glass, sand and cut glass fibers 4.5 mm and 12 mm long. The influence of the volume of fibers and the length of glass fibers on the properties of polymer concrete with 30% by volume of epoxy resin, acting as a binder was described. Tests of CRT glass were carried out, among others study of chemical composition, particle size distribution and analysis of grain morphology. For polymer concrete, the flexural strength and compressive strength were determined, and the open porosity, apparent density, and water absorption were examined. The test results showed that polymer concrete with the use of milled CRT glass is a good way to manage this problematic waste. The polymer concrete has several times better than traditional concretes and significantly lower porosity and water absorption, which makes this material advantageous in applications such as the production of thin-walled products and products exposed to water and chemical attack. The addition of chopped glass fibers leads to an increase in mechanical properties and also protects the material against rapid disintegration after exceeding the maximum tresses, which is extremely important for the safety of use of the structure in the event of a failure.
Features of non-destructive testing of existing masonry structures made of autoclaved aerated concrete units
Authors: Jasiński Radosław , Drobiec Łukasz , Mazur Wojciech
Published: January 2023

The article describes the possibilities of non-destructive testing of existing structures, made of autoclaved aerated concrete [AAC] masonry units. Relationships that allow the determination of the normalized compressive strength of autoclaved aerated concrete, were developed with the MDT semi-non-destructive method. The general form of the Neville curve, known from the diagnosis of plain concrete was used, which was calibrated to AAC of nominal density classes 400, 500, 600 and 700. The tests were performed and additional empirical relationships were built, to allow for the influence of density and moisture. Moreover, an ultrasonic non-destructive NDT method calibrated on standard cubic 100 × 100 ×100 mm samples of various densities and moisture, is presented. In addition to the non-destructive ultrasound method, the sclerometric method, calibrated on the entire masonry elements, limited to one nominal density of 600 kg/m3 with varying moisture, was also used. A practical application of AAC strength assessment in the existing masonry structure, has been presented.
Experiences and Perceptions of Special School Personnel Regarding Inclusive Education: A Qualitative Study
Authors: Chaudhary Farwa
Published: January 2023

The present study explored the experiences and perceptions of psychologists with regards to the benefits of inclusive education for special needs children. The phenomenological approach was used, and data was collected from four psychologists in the form of semi-structured interviews. Thematic analysis was used to interpret the data. The following themes emerged in favor of inclusive education: (i) Providing Support to Special Need Students; (ii) Requiring Qualifications and Experienced Teachers; (iii) Offering Training to School Staff; (iv) Identifying Barriers that Interfere with Inclusion: Stigma and Integration; and (v) The Positive Effects of Inclusive Education: Empathy, Social Skills, and Academic Achievement. The importance of training teachers and staff in inclusive education was also highlighted. The present study indicates that awareness programs are required to remove the social stigma against children with special needs in advancing inclusive education in Pakistan.
Pak-China Defense Cooperation and Evolving International Relations
Authors: Jahangir Javeria
Published: January 2023

This study is about the impact of different global and regional changes resulting from PakistanChina’s defense cooperation and further examines the increasing range of diplomatic cooperation in the social, tactical, and economic realms. The paper focuses on three events: (i) the 1978 transformation of China and its opening-up policies; (ii) disbanding of the U.S.S.R (1991); and (iii) the event of 9/11 in the United States. These events had a significant influence on Pak-China ties. This study is a literature review and contributes to a better understanding of the evolving international systems namely the India-U.S. tactical relations and strategic cooperation. The paper concludes that China and Pakistan need to preserve amicable, strategic, and diplomatic connections with one another as it is necessary for the peace, security, and economic development of not only China and Pakistan but for the region overall. Keywords: Pakistan-China Relations, Indian Concern, Regional Peace, Defense Cooperation,
POLYAMINES AS NEW POTENTIAL BIOMARKERS FOR DIFFERENTIAL DIAGNOSIS OF PROSTATE CANCER AND ESTIMATION OF ITS AGGRESSIVENESS
Authors: Zaletok S.P. , Klenov O.O. , Bentrad V.V. , Prylutskyi M.P. , Vitruk Yu.V. , Stakhovsky E.O. , Timoshenko A.V.
Published: January 2023

Background: Prostate cancer (PCa) is one of the most common malignancies in older men. The study of tissue markers of PCa can provide information about the state of proliferation and apoptosis in tumors, the susceptibility of tumor cells to metastasis and the mechanisms of resistance to therapy, which, in turn, can help predict the course of the disease and develop personalized treatment. Polyamines (PAs) spermine, spermidine, putrescine are of particular interest in terms of PCa tissue markers. Aim: To investigate the levels of basic and acetylated forms of PAs in the postoperative samples of malignant and benign tumors of the human prostate and evaluate the possibility of their use for differential diagnosis and assessment of the PCa aggressiveness. Object and Methods: 57 postoperative tumor samples from patients with prostate adenocarcinoma of different Gleason score (GS) and clinical stage (T1–T4) and 20 samples of tumors from patients with benign prostate hyperplasia (BPH) were studied. The content of PAs was determined by high performance liquid chromatography. Results: Among the studied PAs, the most significant difference between PCa and BPH was observed for spermine (Spm). The level of Spm in PCa samples was 16 times lower than in BPH samples (p < 0.01). We did not find a significant dependence of PAs levels, including Spm, on the clinical stage. The association between the Spm level and the GS was established. The indolent (GS6) tumors were characterized by the highest Spm level while in the most aggressive (GS9 and GS10) tumors Spm content was the lowest. Conclusions: A sharp decrease in Spm levels is probably a characteristic feature of prostate malignant tumors. The obtained results indicate an association of Spm levels in tumors with the GS. This may indicate Spm involvement in the formation of the aggressiveness of PCa. The results of the study can be further used for differential diagnosis of prostate tumors and for assessing the aggressiveness of PCa.
PROGNOSTIC ROLE OF RESIDUAL TUMOR FEATURES IN HER2-NEGATIVE BREAST CANCER
Authors: Sivak L.A. , Lyalkin S.A. , Verevkina N.O. , Shipko A.F.
Published: January 2023

The aim of the study was to examine the prognostic value of immunobiological markers (tumor-infiltrating lymphocytes (TILs) and their subpopulations) in residual tumor after neoadjuvant chemotherapy (NACT) completion in patients with triple negative (TNBC) and luminal B HER2-neu negative breast cancer (LBBC). Materials and Methods: The analysis of the treatment results of 59 patients with TNBC and 56 patients with LBBC with stage IIB–IIIB who received NACT was performed. The levels of TILs and their subpopulations (FOXP3+, CD4+, CD8+) in patients at the time of diagnosis in core-needle biopsy material and in residual tumor in postoperative material were studied by immunohistochemical method. Results: The risk of recurrence in patients with LBBC who received NACT before surgery is associated mainly with 4 factors: FOXP3+ lymphocytes, Ki-67 index in residual tumor, the number of affected axillary lymph nodes after NACT and viable residual tumor volume. Analysis of the treatment outcome in patients with TNBC revealed that the lack of pathologic complete response (pCR) after NACT increases the risk of disease recurrence by 2.9 times, hazard ratio (HR) = 2.9 (95% confidence interval (CI) 1.4–6.1; p = 0.005) compared with patients in which pCR was achieved after NACT. It was also found that the presence of residual tumor in patients with TNBC after NACT increases the risk of death from this disease by 2.7 times (95% CI 1.0–7.1; p = 0.05). Increased intratumoral and stromal CD8+ lymphocyte counts in the residual tumor after NACT significantly reduces the risk of death from TNBC, HR = 0.6 (95% CI 0.5–0.9; p = 0.01) and HR = 0.6 (95% CI 0.4–0.9; p = 0.008), respectively. Increase in intratumoral CD4+ lymphocytes in residual tumor in the non-pCR group reduces by half the risk of death from TNBC, HR = 0.5 (95% CI 0.3–1.0; p = 0.05). Conclusion: The results of our study indicate a favorable prognostic value of TILS in residual tumor in TNBC. It is also reasonable to include the determination of the level of FOXP3+ lymphocytes in the residual tumor in the standard algorithms for stratification of risk groups.
OVARIAN TOXICITY OF FAC CHEMOTHERAPY IN RATS AND POSSIBILITY OF ITS CORRECTION WITH PLATELET-RICH PLASMA
Authors: Shamrai V.A. , Misiurko O.I. , Grebeniuk D.I. , Taran I.V.
Published: January 2023

Aim: To compare the dynamics of changes in the hormonal status of female rats in the setting of the FAC (5-fluorouracil, doxorubicin and cyclophosphamide) chemotherapy and after local administration of platelet-rich plasma (PRP). Materials and Methods: The study was carried out on female Wistar rats treated according to the FAC chemotherapy scheme (4 courses with a 3-week interval). The ovariotoxic effect of the FAC chemotherapy was assessed by the levels of anti-Mullerian hormone, estradiol (E2) and follicle-stimulating hormone in the proestrus phase. Three weeks after the last course of chemotherapy, 5 rats were administered with local intra- and periovarian injection of PRP (triply with a 1-week interval). Results: The dynamics of all investigated hormonal markers of the ovarian reserve in experimental animals was characterized by a progressive decrease in anti-Mullerian hormone and E2 levels and an increase in follicle-stimulating hormone level. The dynamics of the studied parameters after the serial administration of PRP demonstrated an improvement in the hormonal status. Conclusion: FAC chemotherapy in the experiment causes premature ovarian failure, and local administration of PRP improves the hormonal parameters of the ovarian reserve.
EXPRESSION OF IMMUNOGLOBULIN SEQUENCES HOMOLOGOUS TO ANTI-SARS-CoV-2 ANTIBODIES AND HIV IN CHRONIC LYMPHOCYTIC LEUKEMIA CASES
Authors: Abramenko I. , Bilous N. , Chumak A. , Martina Z. , Dyagil I. , Bazyka D.
Published: January 2023

Background: Identification of epitopes recognized by leukemic B cells could provide insights into the molecular mechanisms of B cell transformation in chronic lymphocytic leukemia (CLL). The aim of this paper was to compare nucleotide sequences of immunoglobulin heavy chain variable region (IGHV) genes in CLL with known sequences directed against antigens of different origins available in public databases. Materials and Methods: Analysis was performed in the groups of 412 unselected CLL patients with productive IGHV gene using polymerase chain reaction followed by direct sequencing. Results: Homology between CLL Ig sequences and antibodies directed against autoantigens was found in 12 patients (2.9%), homology between CLL Ig sequences and antiviral antibodies — in 35 patients (8.5%). Most of these sequences belonged to stereotypical clusters. Among the sequences that have homology to antiviral antibodies, the most prevalent were cases homologous with antibodies against HIV (14 cases, 3.4%) and SARS-CoV-2 antigens (10 cases, 2.4%). None of the patients in our cohort was HIV-infected and the study was conducted before the emergence of SARS-CoV-2 virus. Conclusions: Suggestions could be made about the possible impact of past infection of SARS-CoV-2 virus on the pathogenesis of CLL. In particular, an increase in the proportion of CLL cases with the expression of some stereotyped BCR and/or an increase of CLL risk in the long-term period after SARS-CoV-2 virus infection is not excluded. This assumption needs to be verified by epidemiological data.
EFFICACY OF AUTOLOGOUS STEM CELL TRANSPLANTATION IN ADULT BURKITT/BURKITT-LIKE LYMPHOMA: A SYSTEMATIC REVIEW
Authors: Joshi U. , Subedi R. , Nepal G. , Gyawali S. , Agrawal V. , Poudyal B.S. , Bhatt V.R. , D’Angelo Ch.R.
Published: January 2023

Background: Burkitt and Burkitt like lymphoma (BL/BLL) are highly proliferative germinal or post-germinal B cell tumors. Few studies have evaluated the impact of autologous stem cell transplantation (ASCT) on disease outcomes. Aim: We performed a systematic review to analyze the efficacy of ASCT as frontline consolidation and for treatment of relapsed/refractory cases in adult BL/BLL. Materials and Methods: Eligible studies with clear outcome measures on the efficacy of ASCT in adult patients with BL/BLL were identified through systematic search. The overall survival (OS), progression-free survival (PFS), complete response (CR), partial response (PR), and progression/relapse were used to assess the efficacy. Results: For patients who underwent ASCT in first CR, 5-year PFS and OS ranged between 70–78% and 70–83% respectively. For relapsed/refractory disease, 5-year PFS and OS were 27% and 31%, respectively. Patients undergoing ASCT for chemoresistant disease fared poorly with 3-year OS of 7% vs 37% for chemosensitive disease (p ≤ 0.00001). The overall response rate to ASCT for patients transplanted in first CR ranged between 71% and 93% and was 37% for patients who were transplanted in disease status other than first CR. Disease progression/relapse was observed in 16–29% of the patients transplanted in first CR, and 55% to 60% in relapsed disease. Conclusion: We found insufficient evidence to support ASCT over chemotherapy alone in the first remission for adult BL/BLL. Evidence supports guidelines recommending ASCT for chemosensitive disease but suggests there is no benefit to ASCT for chemoresistant disease.
ANALISIS ASPEK SOSIAL BUDAYA DALAM NOVEL “KKN DI DESA PENARI” KARYA SIMPLEMAN: TINJAUAN SOSIOLOGI SASTRA
Authors: Contessa Emilia , Lasmiatun Lasmiatun , Aprizal Dedi
Published: January 2023

Penelitian ini membahas aspek sosial budaya yang terdapat dalam novel “KKN di Desa Penari” karya Simpleman. Tujuan penelitian ini adalah untuk (1) mendeskripsikan struktur (tema, alur, latar, tokoh dan penokohan) yang membangun di dalam novel KKN di Desa Penari karya Simpleman. (2) mendeskripsikan aspek sosial budaya dalam novel KKN di Desa Penari karya Simpleman. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Penelitian ini menggunakan pendekatan sosiologi sastra. Teknik pengumpulan data yang digunakan yaitu teknik dokumentasi, dan teknik analisis data menggunakan teknik analisis karya. Hasil penelitian ini mengungkapkan bahwa novel “KKN di Desa Penari” karya Simpleman memiliki unsur pembangun meliputi tema yang terdiri dari tema mayor dan tema minor, alur yang digunakan adalah alur campuran, latar terdiri dari latar tempat, latar waktu, dan latar sosial-budaya, kemudian tokoh terdiri dari tokoh utama terdapat dua tokoh sedangkan tokoh tambahan terdapat dua belas tokoh. Selain itu ditemukan pula aspek sosial budaya dalam novel KKN di Desa Penari karya Simpleman. Aspek sosial berupa interaksi sosial terdiri dari kerja sama dan pertentangan, sedangkan aspek budaya berupa unsur kebudayaan terdiri dari peralatan dan perlengkapan hidup, mata pencaharian hidup, sistem kemasyarakatan, bahasa, kesenian, sistem pengetahuan, dan religi (kepercayaan).
Handphone Product Selection System Using the Profile Matching Method
Authors: Firmansyah Muhammad Kukuh , Swanjaya Daniel , Wulanningrum Resty
Published: January 2023

Produsen handphone pada saat ini menawarkan banyak produk yang berbeda dengan spesifikasi yang berbeda. Target konsumen dari kelas bawah sampai dengan kelas atas. Produk yang ditawarkan serta spesifikasinya yang bervariasi sangat banyak, menjadikan konsumen atau calon pembeli kesulitan ingin membeli handphone yang mana. Atas dasar permasalahan tersebut, untuk memberikan kemudahan konsumen dalam menentukan handphone sesuai dengan kriteria yang diharapkan, maka dibutuhkan suatu sistem pendukung keputusan yang digunakan untuk memilih handphone. Sistem tersebut menggunakan metode Profile Match yang merupakan teknik pencocokan dengan mencari handphone yang konfigurasinya sedekat mungkin dengan konfigurasi handphone yang ditentukan pada sistem. Penelitian ini menggunakan analisis dan perancangan sistem berupa UML (unified modeling language) dengan analisis use case diagram, activity diagram dan sequence diagram. ERD (Entity Relational Diagram) dan tabel relasi. Pada penelitian ini digunakan sebagai perancangan basis data. Bahasa pemrograman yang diterapkan untuk membangun sistem ini menggunakan PHP dan MySQL sebagai database-nya. Penelitian ini meng.hasilkan sistem pemilihan produk handphone menggunakan metode Profile Match yang dapat memudahkan konsumen dalam menentukan handphone yang dipilih berdasarkan kriteria yang diinginkan.
Weld Defect Classifier Using GLCM Extraction and ANN
Authors: Maulana Agung , Yuliana Dian Efytra , Kusumastutie Diah Arie Widhining
Published: January 2023

Saat ini teknologi di bidang kontruksi berkembang sangat pesat dan semakin maju, hal itu tidak bisa dipisahkan dari pengelasan karena mempunyai peranan penting dalam rekayasa logam. Dalam kehidupan sehari-hari rekayasa logam bisa kita rasakan manfaatnya seperti kontruksi bangunan, alat tranportasi, hiasan, serta banyak lagi lainnya. Pada penelitian ini dilakukan pengklasifikasian jenis cacat las dengan cara merancang sistem klasifikasi mengunakan metode ekstraksi GLCM dan JST dengan jumlah sample citra 400 yang disusun di dataset. Alur pada system klasifikasi ini pra proses dan pada saat proses. Pada tahap pra proses dilakukan gray scaling untuk mengetahui citra keabuan pada citra. Selajutnya yaitu processing nilai yang didapat dari citra keabuan diekstraksi menggunakan GLCM dengan mencari nilai dari 4 fitur (kontras, homogenitas, energi, korelasi). Proses klasifikasi dilakukan dengan menggunakan nilai 4 fitur yang dijadikan input-an yang nantinya output-nya berupa 4 jenis cacat las yang sudah ditargetkan menggunakan hiden layer 20 30 4 yang menghasilkan tingkat akurasi pada sistem 99,375% dari 320 sampel dan dari data uji mendapatkan 87,5% dari 80 sampel.
Blynk Android App-Based System Smart Home Prototype
Authors: Syah Muhammad Fakhrudin , Shalahuddin Yanu
Published: January 2023

Rumah cerdas mode manual dan mode otomatis menggunakan mikrokontroler NodeMCU dimana beban rumah di monitoring dan di kendalikan menggunakan aplikasi Blynk. Pertama lampu otomatis menggunakan sensor LDR dengan batasan nilai ADC sebesar 400. Kedua lampu manual di kontrol ON (menyala) dan OFF (tidak menyala) menggunakan aplikasi Blynk. Ketiga control otomatis menggunakan sensor dht11 untuk mengendalikan kipas dengan batasan suhu di atas 26° dan kelembaban di bawah 40% dua kipas menyala bersama, suhu 25° dan kelembaban 40% - 55% ssatu kipas saja yang menyala dan suhu di bawah 23° kelembaban di atas 55% kedua kipas tidak menyala. Hasil penelitian menunjukkan bahwa alat menggunakan mikrokontroler NodeMCU bekerja dengan baik untuk otomatisasi lampu dan kipas. Kemudian untuk kondisi kendali manualnya pada sistem dapat dilakukan sejauh 10 meter.
Foundation and Frontier – Centenary Path of Dental Anthropology in China
Authors:   Lomonosov Moscow State University, Faculty of Biology, Department of Anthropology, Leninskie Gory, 1(12), Moscow, 119234, Russia, Lin Guo
Published: January 2023

Dental anthropology has been developed for 100 years in China. In this paper, the author reviews the articles on dental anthropology related to Chinese materials in the past one hundred years and briefly introduces the issues involved such as human evolution, and the interaction of different populations in historical periods. Results and discussion. The work of foreign scholars has been the foundation of Chinese paleoanthropology and dental anthropology since the discovery of the Hetao human teeth and the Zhoukoudian site. Since then, dental anthropology in China has gone through a phase of material accumulation, a phase of introducing the American ASUDAS in the 1990s, and a phase of prosperity in the last 30 years. The numerous discoveries and the application of new techniques have brought Chinese dental anthropology to an international level. Until now, there are more than 70 human fossil sites in China, over 60 of which contain human dental remains. Less material has been found from the early Pleistocene, and there is some controversy on whether they belong to the genus Homo. While early Middle Pleistocene Homo erectus teeth show primitiveness and some special features, the late Middle Pleistocene human teeth show greater variability, and mosaic features, and there is some controversy on whether some fossils belong to early Homo sapiens or other taxa. The Late Pleistocene human dentition is related to the question of how and when early modern human appeared in China and the evolution of early modern humans. However, due to the incompleteness of the material, the question of human origins is a matter of multidisciplinary and comprehensive interpretation. About 10 sites were studied from Neolithic to modern human dentition using the American ASUDAS. These results show the consistency of non-metric traits in teeth and skulls, display differences between northern and southern Chinese populations, and reveal the exchange between northwestern Chinese and western populations. Some of these results have been confirmed by paleogenomics. Conclusion. Anthropologists began to pay more attention to the morphology of modern human teeth. In the future, the application of new methods and the collection of modern human materials will help us better understand the evolution of ancient humans, population interaction.
Assessment of environmental risk related to the polycyclic aromatic hydrocarbons (PAH) in the sediments along the eastern Adriatic coast
Authors: Mandić Jelena , Veža Jere , Kušpilić Grozdan
Published: January 2023

Polycyclic aromatic hydrocarbons (PAH) were investigated in the sediments at 24 locations in the coastal area of Adriatic Sea. Total PAH concentrations ranged from 14,98 to 26145,62 µg kg-1, with the highest levels determined in the sediments of Šibenik Bay and the lowest in the sediment near Island of Pag. Unsubstituted PAH were prevailing PAH group in the sediments from the Šibenik Bay and in the Coastal area, while methyl-substituted PAH were dominant group in the sediments of the Kaštela Bay. In order to estimate the possible toxicological significance of PAH concentrations, Sediment Quality Assessment was done according to three different sets of sediment quality guidelines. A high environmental risk was calculated for each station in Šibenik Bay; for the station in vicinity of the Industrial port of Split and for the two stations in Coastal zone. Low environmental risk was determined in less urbanised areas such as Island of Pag. Sediment extracts were further analysed for acute toxicity by measurements of decrease in bioluminescence upon exposure to sediment extracts. Obtained results show disagreement between sediment toxicity predicted upon PAH levels in sediment and experimentally obtained sediment toxicity. Sediment extracts in which low PAH levels were measured showed high acute toxicity indicating that concentrations of PAH alone are a poor indicator of sediment toxicity. Correlation analysis between concentrations of specific PAH compounds and toxicity revealed the strongest association between acute sediment toxicity and sulphur-containing PAH suggesting the S-PAH should be considered in sediment toxicity assessment.