bluuebunny/crossref_metadata_2025 huggingface dataset:
Peak troponin I level predicts new-onset atrial fibrillation in patients with myocardial infarction
Authors: Zehir Regayip , Tekkesin Ahmet I , Haykir Nahide , Velibey Yalcin , Borklu Edibe B , Gumusdag Ayca
Published: May 2017

Purpose: We aimed to assess the predictive value of peak troponin I level for the occurrence of new-onset AF in myocardial infarction.

Methods: A total of 1553 patients, who were hospitalized with diagnosis of STEMI and underwent primary PCI, were retrospectively evaluated. New-onset AF was defined as any newly diagnosed AF that occurred during index hospitalization after primary PCI.

Results: New-onset AF was observed in 90 patients (5.8% of the study population). Patients who developed AF were older (56.1 vs. 62.6 years, p
Proceedings of Peer-reviewed and selected articles from Turgut Ozal University Faculty of Medicine 7th International Student Congress
Authors: Ceylan Furkan S
Published: May 2017

Turgut Ozal University Scientific Research Committee (TOBAT) was established in at the Turgut Ozal University Faculty of Medicine in 2009 to encourage young medical students and scientists to carry out novel scientific research in addition to their medical education. Every year a Committee (Chair, Student Member and Scientific and Social Committees and Advisory Chair) is set up by the volunteer students and their advisors as chair, general secretary, scientific and social committee with the help of previous year’s committee to organize the congress, with the help of previous year’s Committee.
Understanding thermal sensitivity at the molecular level and developing temperature-based systems using RNA Thermometers
Authors: Gul Fatih , Orhan Ibrahim Y , Ceylan Furkan S , Akdeniz Nadir B , Karadag H Abdulkadir
Published: May 2017

Purpose: Temperature sensitivity is found in all multicelleular organisms, as well as in most primitive life forms. The ubiquity of this temperature sensitivity is an indicator of its effects at the multicellular, cellular and molecular levels [1]. Previous studies have shown that temperature-based regulation is present in the transcriptional process [2]. RNA Thermometers, temperature-sensitive sequences, have been shown to act on heat-shock genes to regulate temperature-dependant systems in many organisms [3,4]. The goal of this study was to characterize the shifts in the functioning of these RNA Thermometers at various temperatures. In addition, using the principle of transcriptional thermoregulation, an automated temperature-responsive system stimulating inverse endothermic and exothermic enzymatic reactions for heat stabilization was proposed.

Methods: The endothermic enzymatic reaction was designated as the breakdown of urea, reflecting the function of urease, and the exothermic reaction was designated as the breakdown of hydrogen peroxide, reflecting the function of catalase [5].

Results: The proposed system was built upon the translation of urease and the inhibition of catalase translation at higher temperatures, and the inverse at lower temperatures. As RNA Thermometers can be used only to drive transcription at higher temperatures, the installation of a lac-regulated 2-way system was suggested. This system would also provide a synthetic solution to thermoregulation and the current systems employed today. This system could be applied where the current thermoregulatory systems prove insufficient and could be further developed and optimized to replace them in the future.
Suppression of bromodomain-containing protein 4 by shRNA: A new approach for cancer treatment
Authors: Kaya Turan , Kahraman Berke , Bazarov Nurgeldi , Toker Alperen S , Celik Ayse , Cigdem Sadik , Gunduz Esra
Published: May 2017

Purpose: MYC is a transcription factor coding gene that is believed to control 15% of the genes in the entire human genome. The central role of c-MYC in cancer pathogenesis makes it a major therapeutic target in field of anticancer agent development.

Methods: We targeted the acetyl-lysine binding modules or bromodomains, which are associated with c-MYC transcriptional activation.

Results: Sequence specific inhibition of BET bromodomains with small hairpin RNAs (shRNAs) resulted in cessation of cellular proliferation in different cancer cell lines. Unlike previous studies on inhibition of bromodomains with selective small-molecule inhibitors, our study revealed the significant role of BET bromodomains in solid tumours and also highlighted the ease of RNA interference (RNAi) methodology for inhibition of bromodomain translation.

Conclusion: The degree of influence of BET bromodomain inhibition on proliferation in five cancer cell lines established it as the major target in malignancies characterized by activation of c-MYC.
Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences
Authors: Kiroğlu Olcay E , Demirkol Kübra E , Berktaş Fatih , Yegani Arash A , Kirpik Ayşegül , Maytalman Erkan , Ünverdi Mahmut , Aksu Fazilet
Published: May 2017

Purpose: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects.

Methods: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks. Dipyrone was administered intraperitoneally beginning from the third week. Splash, rota-rod (RR) and forced swimming (FST) tests were performed at the seventh week as behavioural tests to evaluate the antidepressant-like effects of dipyrone. Coat state score (CSS) and weights of animals were recorded at seventh weeks. Results were analyzed using one or two-way ANOVA followed by the Bonferonni post hoc test.

Results: Weight of UCMS-exposed mice did not change compared with controls; however, significant changes were observed in CSS in both sexes of stressed mice (p
Effects of Long-Term Training Program on Static and Dynamic Balance in Young Subjects
Authors: Gürkan Alper Cenk , Demirel Havva , Demir Merve , Atmaca Emine Şeyda , Bozöyük Gülnihal , Dane Senol
Published: May 2017

Purpose: The purpose of this study was to examine the efficacy of a long-term training program of 10 weeks on static and dynamic balance parameters in a young healthy population.

Methods: Participants were 35 young healthy female subjects. Balance measurements were done using the Flamingo Balance Test (FBT) for static balance and the Star Excursion Balance Test (SEBT) for dynamic balance.

Results: Dynamic balance points increased and static balance points decreased after a 10 week training protocol compared with before training, indicating improvement in both dynamic and static balance.

Conclusions: These results indicate that long term training resulted in an improvement both static and dynamic balance. Training can be suggested for patients with balance problems.
Retrospective air bone gap evaluation of patients with tympanic membrane central perforation
Authors: Küçükkavruk Levent , Temügan Esra , Kaya Mesut , Unsal Selim , Gumus Nebi Mustafa , Yüksel Mustafa , Gündüz Mehmet
Published: May 2017

Purpose: The purpose of this study was to evaluate hearing recovery and air-bone gap (ABG) before and after tympanoplasty surgery in patients with tympanic membrane central perforation.

Methods: Histories and audiological assessments of 160 cases (total of 26 ears from 22 patients; 11 men and 11 women) from patients who had undergone tympanoplasty surgery and hearing reconstruction due to tympanic membrane central perforation were evaluated. Pre-postoperative audiograms and the pure tone, air-bone hearing thresholds and ABG gains were evaluated.

Results: The mean age of the patients was 38.6 years (± 16.04). The mean postoperative follow-up period was 13.4 months (± 15.5). The mean preoperative ABG was 25.36 dB (± 9.9) and postoperative ABG was 17.36 dB (± 11.68) (p = 0.001). When four groups were compared before surgery and after surgery period as 0-6 months, 6-12 months, 1-2 years and 2 years in terms of pre- and postoperative ABG values, no statistically significant difference was observed (p>0.05). All patients were divided into three groups: < 20 years of age; between the ages of 21-40; and, >41 years of age, and no statistically significant difference were found between the groups (p> 0.05). Surgeries of the patients 21-40 years of age were more successful (ABG gain) than other age groups. No statistically significant gender differences were found in ABG averages (p = 0.33), but clinical results were significantly better in women as compared with men.

Conclusion: In patients with central tympanic membrane perforation, tympanoplasty surgery with temporal fascia is beneficial in terms of hearing recovery.
Investigation of the expression of RIF1 gene on head and neck, pancreatic and brain cancer and cancer stem cells
Authors: GursesCila Hacer E , Acar Muradiye , Barut Furkan B , Gunduz Mehmet , Grenman Reidar , Gunduz Esra
Published: May 2017

Purpose: Recent studies have shown that cancer stem cells are resistant to chemotherapy. The aim of this study was to compare RIF1 gene expression in head and neck, pancreatic cancer and glioma cell lines and the cancer stem cells isolated from these cell lines.

Methods: UT-SCC-74 from Turku University and UT-SCC-74B primary tumor metastasis and neck cancer cell lines, YKG-1 glioma cancer cell line from RIKEN, pancreatic cancer cell lines and ASPC-1 cells from ATCC were grown in cell culture. To isolate cancer stem cells, ALDH-1 for UT-SCC-74 and UT-SCC-74B cell line, CD-133 for YKG-1 cell line and CD-24 for ASPC-1 cell line, were used as markers of cancer stem cells. RNA isolation was performed for both cancer lines and cancer stem cells. RNAs were converted to cDNA. RIF1 gene expression was performed by qRT-PCR analysis. RIF1 gene expression was compared with cancer cell lines and cancer stem cells isolated from these cell lines. The possible effect of RIF1 gene was evaluated.

Results: In the pancreatic cells, RIF1 gene expression in the stem cell-positive cell line was 256 time that seen in the stem cell-negative cell line.

Conclusion: Considering the importance of RIF1 in NHEJ and of NHEJ in pancreatic cancer, RIF1 may be one of the genes that plays an important role in the diagnoses and therapeutic treatment of pancreatic cancer. The results of head and neck and brain cancers are inconclusive and further studies are required to elucidate the connection between RIF1 gene and these other types of cancers.
Potential beneficial effects of foot bathing on cardiac rhythm
Authors: Aydin Duygu , Hartiningsih Siti Sugih , Izgi Melike Gokce , Bay Sevgi , Unlu Kubra , Tatar Meryem Ozlem , Alparslan Ayse Melike , Ozeri Mohammed , Dane Senol
Published: May 2017

Purpose: Foot bathing therapy is a simple technique that induces sensations of comfort and relaxation. The aim of this study was to examine the effect of foot bathing therapy on heart rate variability (HRV) parameters in a healthy population.

Methods: Participants were twenty healthy female subjects (median age=20.67 years, SD=1.04). The recording ECG was applied for 5 minutes before and for 5 minutes after foot bathing therapy of 10 minutes. Subjects rested for 10 minutes without recording ECG in order to stabilize autonomic parameters. The digital signals were then transferred to a laptop and analyzed using LabChart® software (MLS310/7 HRV Module).

Results: Almost all HRV parameters increased and heart (pulse) rate and LF/HF ratio decreased after foot bathing therapy compared with before foot bathing therapy.

Conclusions: These results indicate for the first time in humans that foot bathing might induce a state of balance between sympathetic and parasympathetic systems and might be helpful to prevent possible cardiac arrhythmias.
High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis
Authors: Yakar Tolga , Demir Mehmet , Dogan Ozlem , Parlakgumus Alper , Ozer Birol , Serin Ender
Published: May 2017

Purpose: We aimed to evaluate and compare the efficacy and safety of high-dose furosemide+salt orally by comparing HSS+ furosemide (i.v.) and repeated paracentesis in patients with RA.

Methods: This was a prospective study of 78 cirrhotic patients with RA, randomized into three groups: Group A (n= 25) i.v. furosemide (200-300 mg bid) and 3% hypotonic saline solution (HSS) (once or twice a day); Group B (n= 26) oral furosemide tablets (360-520 mg bid) and salt (2.5 g bid); and, Group C (n= 27) repeated large-volume-paracentesis (RLVP) with albumin infusion. Patients without hyperkalemia were administrated 100 mg of spironolactone/day. During the follow-up; INR, creatinine, and total bilirubin levels were measured to determine the change in MELD (model of end stage liver disease) score.

Results: Hepatic encephalopathy (HE), severe episodes of spontaneous bacterial peritonitis (SBP) and pleural effusions (PE) occurred more frequently in Group C. Improvement in Child-Pugh and MELD score was better in Group A and B than Group C. In Group B, improvements were seen in the Child-Pugh and MELD score, reduction in body weight, duration and number of hospitalization. In Groups A and B, remarkable increases in diuresis were observed (706±116 to 2425±633 mL and 691±111 to 2405±772 mL) and serum sodium levels also improved. HE and SBP were occurred more often in group C (p
Facial emotion recognition ability: psychiatry nurses versus nurses from other departments
Authors: Gultekin Gozde , Kincir Zeliha , Kurt Merve , Catal Yasir , Acil Asli , Aydin Aybike , Özcan Mualla , Delikkaya Busra N , Kacar Selma , Emul Murat
Published: May 2017

Purpose: Facial emotion recognition is a basic element in non-verbal communication. Although some researchers have shown that recognizing facial expressions may be important in the interaction between doctors and patients, there are no studies concerning facial emotion recognition in nurses. Here, we aimed to investigate facial emotion recognition ability in nurses and compare the abilities between nurses from psychiatry and other departments.

Methods: In this cross-sectional study, sixty seven nurses were divided into two groups according to their departments: psychiatry (n=31); and, other departments (n=36). A Facial Emotion Recognition Test, constructed from a set of photographs from Ekman and Friesen's book “Pictures of Facial Affect”, was administered to all participants.

Results: In whole group, the highest mean accuracy rate of recognizing facial emotion was the happy (99.14%) while the lowest accurately recognized facial expression was fear (47.71%). There were no significant differences between two groups among mean accuracy rates in recognizing happy, sad, fear, angry, surprised facial emotion expressions (for all, p>0.05). The ability of recognizing disgusted and neutral facial emotions tended to be better in other nurses than psychiatry nurses (p=0.052 and p=0.053, respectively)

Conclusion: This study was the first that revealed indifference in the ability of FER between psychiatry nurses and non-psychiatry nurses. In medical education curricula throughout the world, no specific training program is scheduled for recognizing emotional cues of patients. We considered that improving the ability of recognizing facial emotion expression in medical stuff might be beneficial in reducing inappropriate patient-medical stuff interaction.
Effect of One Unit Blood Donation on Appetite-Related Biomarkers
Authors: Erdamar Husamettin , Cakmak Muzaffer
Published: May 2017

Purpose: It is commonly reported that blood donation (BD) leads to an increase in appetite. To investigate this claim, a questionnaire was offered to 306 people who had a history of BD at least once in their life. Following a positive outcome from the questionnaire, we further investigated the impact of BD on appetite.

Materials and Methods: The questionnaire study consists of a 5-question survey with VAS was performed on 399 volunteers. Later, 108 volunteers were enrolled in a laboratory study. Blood samples were withdrawn before and after BD. Leptin, ghrelin, neuropeptide-Y (NPY), and alpha-melanocyte stimulating hormone (α-MSH) levels were measured by ELISA kits. VAS assessment was also performed on all participants before and after BD.

Results: There was a significant decrease in the level of leptin but the levels of ghrelin, NPY and α-MSH were unchanged. A significant change in VAS value in terms of appetite was also observed.

Conclusion: The elevation of appetite after BD is predominantly psychological. Hormonal changes may contribute to the control of hypothalamic hunger and satiety centers.
Protective Effect of Intravesical Platelet-Rich Plasma on Cyclophosphamide-Induced Hemorrhagic Cystitis
Authors: Ozyuvali E , Yildirim ME , Yaman T , Kosem B , Atli O , Cimentepe E
Published: May 2017

Purpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC).

Material-Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP). Rats were randomly allocated to one of four groups (n = 6 per group): a control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1; a IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, a intravesical PRP‑treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia.

Results: Histological evaluation showed that bladder inflammation in CYP‑treated rats was not suppressed by PRP. CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but PRP was not found to be effective to decrease these effects.

Conclusion: The application of PRP could not reverse the histopathological changes in rats that had interstitial cystitis due to the cyclophosphamide injection.
Unenhanced computed tomography findings of renal papillae in patients with a ureteral stone
Authors: Serter Selim , Sahin Erkan , Yildirim Utku Mahir , Arslan Murat , Karakose Ayhan
Published: May 2017

Purpose: In some patients with a ureteral stone without uretero-hydronephrosis, it is difficult to determine the location of the stone. The objective of the present study was to investigate the changes in renal papillae using unenhanced computerized tomography (uCT) and determine the side of calculi using the renal papillary findings in patients with a ureteral stone.

Methods: uCT data from 81 patients were retrospectively reviewed for this study. The inclusion criteria were unilateral ureteral calculi, no renal calculi and no hydronephrosis. For each patient, three measurements of CT attenuation of 0.05 cm2 area were made in the tip of the interested renal papillae, both stone side and non-stone side. Student’s t test was used for statistical analysis.

Results: Forty-one right-sided and 40 left- sided isolated unilateral ureteral calculi patients were evaluated by uCT exam. The average attenuations of the tip of the papillae in stone side and non-stone side were 34.1 Hounsfield units (HU) and 30.6 HU, respectively. There was a statistically significant difference between stone and non-stone sides (p< 0.05).

Conclusion: During routine practical uCT applications, it can be difficult to distinguish phleboliths, ureteral stone or the existence of non-opaque ureteral stone, so papillae density measurements can be a practical method to identify the existence of ureter stone and its location (side).
Comparison of neck ultrasonography with a pH meter to confirm correct position of nasogastric tube
Authors: Muslu Bunyamin , Demircioglu Rüveyda I , Gözdemir Muhammet , Usta Burhanettin
Published: May 2017

Purpose: The aim of this study was to compare pH meter and neck ultrasonograph for evaluation of nasogastric tube (NGT) position.

Methods: A total of 35 adult patients who required NGT insertion were included. The NGT was inserted by an anesthetist after endotracheal intubation, and the transducer was placed transversely on the neck, just superior to the suprasternal notch. The passage of the NGT in the esophagus was evaluated by a sonographer, and the stomach was emptied by nasogastric suction. Secretion from inside the NGT was analyzed using a pH meter. The tip of the NGT was accepted as being in the stomach if the pH measured between 1 and 5. Neck ultrasonography was compared with the pH meter analysis for confirmation of NGT position.

Results: Ultrasonography was highly sensitive (100% (95% CI 89.6–100%) and specific (97.2% (95% CI 85.4–99.5%) for evaluation of NGT position. The specificity for the pH meter was 100% (95% CI 16.6–100%), while the sensitivity was 76.5% (95% CI 58.8–89.2%).

Conclusions: This study showed that neck ultrasonography is more sensitive than the pH meter for confirmation of NGT position.
Acute Appendicitis in Pregnant Women: Our Clinical Experience
Authors: Türkan Ahmet , Yalaza Metin , Kafadar Mehmet Tolga , Değirmencioğlu Gürka
Published: May 2017

Purpose: The purpose of this study was to analyse 13 patients who were treated in our clinic due to acute appendicitis during pregnancy.

Methods: Records of the patients who received appendectomy with appendicitis diagnosis in our Turgut Özal University Research and Application Hospital between January 2007 and December 2015 have been analyzed retrospectively.

Results: Appendectomies were performed on 13 pregnant patients with an acute appendicitis diagnosis. Average age of the patients was 27.69 years (between 22-37 years). Most frequent complaint of the patients was abdominal pain and most frequent examination finding was tenderness at right lower quadrant. Ultrasonography was used in all cases for diagnosis. Surgery was decided with clinical diagnosis for five cases (38.5%) where appendix had not been identified with ultrasonography. While laparoscopic appendectomy was applied in one case (7.7%) and open appendectomy was applied using a McBurney incision in 12 cases (92.3%). Average hospitalization duration was 1.69 days. All patients were tracked together through the Gynaecology Department for two weeks after they had been discharged from the hospital. Preterm delivery, maternal and fetal loss did not occur.

Conclusion: It is considered appropriate to apply ultrasonography routinely to all pregnant patients in whom acute appendicitis is suspected. Concern for maternal or fetal complication that may occur in consequence of an unnecessary surgery should not be at a level that will delay surgical treatment needed by the patient.
Nasobiliary Drainage for Benign Recurrent Intrahepatic Cholestasis in Patients Refractory to Standard Therapy
Authors: Yakar Tolga , Demir Mehmet , Gokturk Huseyin S , Unler Kanat Ayse G , Parlakgumus Alper , Ozer Birol , Serin Ender
Published: May 2017

Purpose: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. The aim of this study was to evaluate the safety and efficacy of nasobiliary drainage (NBD) in patients with BRIC refractory to medical therapy and to determine whether the use of NBD prolongs the episode duration.

Methods: This was a multicenter retrospective study consisting of 33 patients suffering from BRIC. All patients were administrated medical treatment and 16 patients who were refractory to standard medical therapies improved on treatment with temporary endoscopic NBD. Duration of treatment response and associated complications were analyzed.

Results: Sixteen patients (43% females) underwent 25 NBD procedures. The median duration of NBD was 17 days. There were significant improvements in total and direct bilirubin and alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase on the 3rd day of NBD. Longer clinical remission was monitored in the NBD group. Post-endoscopic retrograde cholangiopancreatography pancreatitis was observed in one of 16 cases.

Conclusion: NBD effectively eliminates BRIC in all patients and improves biomarkers of cholestasis. It can be suggested that patients with attacks of BRIC can be treated with temporary endoscopic NBD; however, the results of this study should be confirmed by prospective studies in the future.
Protective Effect of Intravesical Platelet-Rich Plasma on Cyclophosphamide-Induced Hemorrhagic Cystitis
Authors: Ozyuvali E , Yildirim ME , Yaman T , Kosem B , Cimentepe E
Published: May 2017

Purpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC).

Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP) and rats were randomly allocated to one of four groups (n = 6 per group): A control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1, IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, an intravesical PRP‑treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia.

Results: Histological evaluation showed CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but that PRP did not suppress these histopathological changes.

Conclusion: PRP did not suppress the histopathological changes in rats that had IC due to cyclophosphamide injection.
Sleep Quality Differs Between Athletes and Non-athletes
Authors: Demirel Havva
Published: May 2017

Purpose: Sufficient sleep or sleep of sufficient quality is essential for the health of children, adolescents and adults, as sleep influences almost all dimensions of life. The purpose of this study was to investigate the possible positive effects of sportsmanship on sleep quality and to assess the possible differences in sleep quality between athletes and non-athletes.

Methods: Sedentary or non-athletes subjects (n=103) and athletes (n=93) participated in this study. The Turkish version of Pittsburg Sleep Quality Index was used to assess the points associated with sleep quality of participants before and one month after wet cupping therapy.

Results: Athletes had statistically significantly higher Pittsburg Sleep Quality Index parameters compared with non-athletes.

Conclusions: Long-term exercise or physical fitness is advised for better health and a life without stress, anxiety and depression and also for the normal brain function and emotional stability
Effect of obstructive sleep apnea on carotid artery intima media thickness related to inflammation
Authors: Kong Delei , Qin Zheng , Wang Wei , Kang Jian
Published: May 2017

Purpose: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for atherosclerosis. To ascertain the effect of OSAHS on the development of atherosclerosis in Chinese OSAHS patients, we evaluated markers of atherosclerosis as well as vascular endothelial function and inflammation.

Methods: Chinese men with polysomnography-diagnosed OSAHS were subgrouped into mild-moderate (n = 28) and severe (n = 54) OSAHS groups on the basis of apnea hypopnea index (AHI) scores. The control group was made up of 30 healthy men. Atherosclerosis was assessed by carotid artery intima-media thickness (IMT) of both sides, flow-mediated dilation (FMD), and inflammation by interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) levels.

Results: Linear regression analysis was used to identify significant associations among risk factors and carotid IMT. The following parameters were significantly higher in patients with severe OSAHS than in the control group: waking triglycerides, total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, blood uric acid, blood glucose, IL-6 and hs-CRP. FMD in severe OSAHS patients was lower than in the control group. AHI score, waking hs-CRP, waking oxidized low-density lipoprotein, blood glucose, and vascular endothelial growth factor (VEGF) level were positively associated with IMT.

Conclusions: In Chinese male patients with severe OSAHS, the significantly higher carotid IMT and levels of inflammatory factors (IL-6 and hs-CRP) and lower FMD suggest that arterial endothelial damage and inflammation may play important roles in the development of atherosclerosis in OSAHS patients.
Training the next generation of Canadian Clinician-Scientists: charting a path to success
Authors: Yin Charles , Steadman Patrick E , Apramian Tavis , Zhou Tianwei E , Ishaque Abdullah , Wang Xin , Kuzyk Alexandra , Warsi Nebras
Published: May 2017

Clinician-scientists are physicians with training in both clinical medicine and research that enables them to occupy a unique niche as specialists in basic and translational biomedical research. While there is widespread acknowledgement of the importance of clinician-scientists in today’s landscape of evidence-based medical practice, training of clinician-scientists in Canada has been on the decline, with fewer opportunities to obtain funding. With the increasing length of training and lower financial compensation, fewer medical graduates are choosing to pursue such a career. MD-PhD programs, in which trainees receive both medical and research training, have the potential to be an important tool in training the next generation of clinician-scientists; however, MD-PhD trainees in Canada face barriers that include an increase in medical school tuition and a decrease in the amount of financial support. We examined the available data on MD-PhD training in Canada and identified a lack of oversight, a lack of funding and poor mentorship as barriers experienced by MD-PhD trainees. Specific recommendations are provided to begin the process of addressing these challenges, starting with the establishment of an overseeing national body that would track long-term outcome data for MD-PhD trainees. This national body could then function to implement best practices from individual programs across the country and to provide further mentorship and support for early-career physician-scientists. MD-PhD programs have the potential to address Canada’s growing shortage of clinician-scientists, and strengthening MD-PhD programs will help to effect positive change.
Analisis Eksistensi Kearifan Lokal Huyula Desa Bongoime Provinsi Gorontalo
Authors: Annas Faris Budiman , Wahyuni Ekawati Sri
Published: May 2017

This study aims to analyze the existence of local wisdom Huyula measured by knowledge, attitudes and behavior of farmers to Huyula and its relationship with the internal and external factors farmers. The sample was Bongoime villagers who work as rice farmers. This study uses quantitative data with qualitative data furnished. This study tested using Spearman rank correlation test with significance level 0,05 level. Results of this study indicate that Huyula is a values contained in the mutual aid society. Farmers have the high knowledge, attitude and behavior towards Huyula although in practice only in the cleaning of irrigation channels. There is a relationship between knowledge, attitudes and behavior of farmers toward Huyula. There are two variabel like age and extention intensity that affects the existence Huyula.

Keywords: economic behavior, fisher, fisheries industrialization
Strategi Pengembangan Karier PNS Fungsional Umum di Institut Pertanian Bogor
Authors: Wijaya Gandi Aria , Ma'arif M. Syamsul , Sukmawati Anggraini
Published: May 2017

The main issues in the field of human resources is a state civil officials on the quality and distribution of civil servants, therefore we need a research to know the civil servant career development strategy. Process and career development should be professional career development oriented of civil servants which means not only the structural purpose, but also to developing expertise towards functional. Thus, the position of the functional has a role as equal partners in a structural position. The purpose of this study is to identify what are the main priorities of the factors, actors and objectives as well as the recommendation of alternative strategies are most influential on the development of common functional civil servants career in IPB. The research was conducted at IPB and the Bureau of Personnel Culture and Education Ministry Secretariat using descriptive analysis and AHP (Analytical Hierarchy Process) methods. The results of the descriptive analysis is from 1.500 civil servants education personnel only 14,3% certain functional officials in IPB, thus 83,7% is common functional PNS included structural officials which selectively will be converted to be specific functional civil service officials. Results obtained from AHP processing the alternative strategy most recommended is the establishment of assessment centers (0,482) by actor Vice Rector of Resources and Strategic Studies (0,498), through the strengthening of organizational factors (0,357) with the aim of increasing professionalism (0,600), that all are the main priorities which influence to the development of a common functional IPB civil servants career.

Keywords: civil servant quality and distribution, professionalism, carrier development strategy, assesment center
Motivasi Petani dalam Pengelolaan Usaha Hutan Rakyat Desa Cingambul, Kecamatan Cingambul, Majalengka
Authors: Suherdi Suherdi , Amanah Siti , Muljono Pudji
Published: May 2017

Private forests have economical, social and environmental benefits. Through the private forests, farmers can support the fulfillment of the household needs, included basic and social needs, as well as appreciation for their initiatives and actions in land rehabilitation. Without strong motivation from farmers, the private forests would be rarely found. Thus, the research objective is to analyze factors motivate farmers do the business and therole of the forests extension workers in the development of private forests. Primary data was collected in CingambulVillage, Sub-District Cingambul, Majalengka from July to August 2013. A number of 81 farmers out of 101 private forest farmers were selected as respondents. A Rank Spearman Correlation was used to analyse factors correlate to motivation of the farmers in running private forests. The research results show that: (1) farmers’ motivation has a positive correlation with the farmer’s perception to the benefits of private forests, attitudes of forest people toward their private forest business, availability of plant species, ease of marketing, frequency of forest extension workers visit, suitability of the material, equipment availability, and accuracy methods applied in the extension activity, and (2) the farmers perceived that the dominant roles of forestry extension are as a advisors, facilitators and as a educators. There is a need to improve the role of extension workers as a motivator for farmers in managing the private forests.

Keywords: motivation, private forests, the role of forestry extension workers.
Strategi Pengembangan Perilaku Komunikasi Guru Responsif Gender
Authors: Arif Ernita , Hubeis Aida Vitayala S , Sugihen Basita Ginting , Purnaningsih Ninuk , Saleh Amiruddin
Published: May 2017

The teacher is a strategic factor in the learning process. For that teachers must have good skills, especially the ability to communicate, because the whole learning process is closely related to communication. But the reality has not been able to optimize the ability of the teacher to the students of boys and girls. This study aims to develop the communication behavior of a gender responsive teachers. The study was designed as ekplanatory survey research conducted by two hundred the number of respondents using Taro Yamane formula. This research was conducted in the city of Padang and Padang Pariaman since June-December 2013. Results showed that the strategy of development of gender responsive teacher communication behaviors through strengthening the internal and external factors.

Keywords: teacher, strategies, gender responsive, learning process
Pengembangan Pertanian Organik di Kelompok Tani Madya, Desa Kebonagung, Kabupaten Bantul, Daerah Istimewa Yogyakarta
Authors: Emiria Firda , Purwandari Heru
Published: May 2017

Organic farming is agricultural activities that seek the use of outside intake and avoid the use of pesticides and synthetic fertilizer. The results showed that the organic farmers and conventional farmers have the high responses of organic farming. However, the characteristics of organic farmer have no relation with farmer’s respons of organic farming. Then, in conventional farmers, formal education and the courage to take the risks have relation with farmer’s respons of organic farming. This research also showed there are no relation between farmer’s respons of organic farming with farmer’s income. Nevertheless, can be predicted that there are chances of the conventional farmers to adopt the organic farming.

Keywords: organic farming, respons, income, conventional farmer
Pengaruh Modal Sosial terhadap Ketahanan Pangan Rumahtangga Petani di Desa Ciaruteun Ilir Kecamatan Cibungbulang Kabupaten Bogor
Authors: Endarwati Sara , Wahyuni Ekawati Sri
Published: May 2017

Social capital is an important component in a community. Social capital is used to help each other when in need, such as the need to secure food sufficiency in a household. Social capital consists of trust, networks, and social norms. Household food security is defined as a condition of food suffiency in one household in terms of availability, accesibility and consumability. This study aims to analyze the roles of social capital in household food security in Ciaruteun Ilir village, Cibungbulang subdistrict at Bogor Regency. The data collected by using a survey to 60 horticultural farmer houselds. The farmer’s household food security is not determined by socio economic level, spending level and the number of household members. Farmers use the capital social to generate income for buying foods.

Keywords: social capital, food security, horticultural farmer
Persepsi Pemuda terhadap Peranan Karang Taruna dalam Penanganan Masalah Sosial
Authors: Handayani Annisa Yulia , Purnaningsih Ninuk , Sarma Ma'mun
Published: May 2017

The government should work with the elements of society to solve a growing social problem, including organizations that exist at the village level. Karang Taruna as one of the youth organizations, is a partner that could take the role in solving social problems. The purpose of this study is to determine how youth perceptions of the Karang Taruna role and the factors that influence these perceptions. Descriptive analytical study design by incidental sampling techniques to 93 youths carried out at Bogor City. Data collection was conducted between February until April 2014. Processed data using regression analysis. The results showed that age, education, motivation, experience, interaction with organization, social environment, knowledge about the social problem and knowledge about karang taruna role in the implementation of social welfare influence statistically significant to youth perceptions about Karang Taruna’s role in solving social problems.

Keywords: role, karang taruna, perception, social problems, karang taruna
Pemanfaatan Cyber Extension melalui Telepon Genggam oleh Petani Anggrek di Taman Anggrek Ragunan, Jakarta Selatan
Authors: Eri Dasli Aira Putri , Muljono Pudji , Susanto Djoko
Published: May 2017

Cyber extension is one of the modern technology which can be utilized by the farmers, extension workers, and Business actors to obtain informations and develop agricultural business. The purpose of this study was to analyze relationship between characteristics of respondents and environmental with the farmers behavior in utilizing cyber extension (Hp and internet) to support farming activities as well as the utilized on farm orchid plants. This study is descriptive correlational type of survey method. Research conducted at the Ragunan Orchid Park, South Jakarta, Jakarta Province. The sample were all growers of orchids as many as 35 people. The behavior of farmers for using cyber media, especially utilized of mobile phones. It also had a positive utilized in the development of farming, especially in marketing orchids in town and out of town. So, the farmers increase consumer and profit.
Keywords: cyber extension, extension workers, utilized, handphone
Tingkat Kompetensi Petani Agribisnis Sayuran Pada Lahan Sempit di Kota Banda Aceh dan Kabupaten Aceh Besar
Authors: Muhibuddin Muhibuddin , Amanah Siti , Sadono Dwi
Published: May 2017

The research objectives are to analyze the level of agribusiness competencies of smallholders with vegetable planting, the correlated factors with agribusiness competence of smallholders with vegetable planting, and the strategies of increasing agribusiness competence of smallholders with vegetable planting. The respondents are vegetable farmers who live in the sub-district Syiah Kuala of Banda Aceh and sub-district Darussalam of Aceh Besar. Sampling was done by simple random sampling. Data collection was conducted on the 77 respondents using survey, interviews and observations technique, starting in April 2015 The descriptive analysis and correlation test (Pearson correlation) were used to analyze the data.The results showed that the level of agribusines competencies of smallholders with vegetable planting in Banda Aceh and Aceh Besar including moderate category. The moderate agribusiness competence is shown by the moderate level of knowledge, attitude, and skill. There is a very real correlation between: the characteristics of the socio-demographic (age, level of formal education, non-formal education, and experience), motivation to farm, interaction and communication of farmers with agribusiness competencies of smallholders with vegetable planting. The effective strategies that can improve the agribusiness competence of smallhoders are: improve training and field school for farmers, increase the interaction and communication of farmers with extension workers, and the development of farmers groups.
Keyword: smallholders,vegetable planting, characteristics, agribusiness competencies
Pengaruh Pelatihan Non Teknis terhadap Kinerja Penyuluh Pertanian BP4K di Kabupaten Bungo Provinsi Jambi
Authors: Putri Ike Wirdani , Fatchiya Anna , Amanah Siti
Published: May 2017

Guna mendukung kinerja penyuluh pertanian BP4K Kabupaten Bungo mengadakan pelatihan non-teknis. Penelitian ini bertujuan untuk: menganalisis kesesuaian pelatihan bagi penyuluh pertanian serta menganalisis kinerja penyuluh pertanian setelah berpartisipasi dalam pelatihan non-teknis. Penelitian dilakukan dengan cara sensus pada 100 responden dan analisis data menggunakan statistik deskriptif dan statistik inferensial (multiple linear regresi). Hasil penelitian menunjukkan bahwa: 1) frekuensi pelatihan dan motivasi dari penyuluh pertanian positif mempengaruhi kinerja penyuluh; 2) Metode pelatihan dan infrastruktur mempengaruhi efektivitas pelatihan. Metode yang lebih inovatif dalam pelatihan dengan didukung oleh infrastruktur yang lebih baik akan meningkatkan kinerja yang lebih baik dari penyuluh; 3) kesesuaian materi pelatihan dan rencana pembelajaran yang lebih baik akan mempengaruhi penyuluh dalam meningkatkan kinerja pelatihan; 4) dukungan fasilitas dari organisasi penyuluhan akan meningkatkan kinerja penyuluh, dan penyuluh pertanian menerima reward/imbalan atas kinerja mereka.
Kata kunci: kinerja penyuluh, pelatihan non-teknis, lembaga penyuluhan kabupaten (BP4K), rencana pembelajaran.
Partisipasi Masyarakat dalam Pencegahan Kebakaran Lahan Gambut di Kabupaten Mempawah, Provinsi Kalimantan Barat
Authors: Sawerah Siti , Muljono Pudji , Tjitropranoto Prabowo
Published: May 2017

Kebakaran lahan gambut di Kalimantan Barat khususnya di Kabupaten Mempawah sering terjadi di setiap musim kemarau. Berbagai upaya pencegahan telah dilakukan pemerintah. Tercapainya pencegahan tersebut tidak terlepas dari partisipasi masyarakat di sekitarnya. Pentingnya partisipasi masyarakat tersebut karena sebagai pelaksana berbagai kegiatan yang diupayakan oleh pemerintah. Penelitian ini menganalisis:1) tingkat partisipasi masyarakat dalam pencegahan kebakaran lahan gambut, 2) hubungan faktor internal terhadap partisipasi, dan 3) hubungan faktor eksternal terhadap partisipasi. Penelitian lapang dilakukan pada bulan Maret hingga Mei 2015 di Kabupaten Mempawah. Populasi penelitian adalah 95 anggota masyarakat yang memiliki lahan pernah terbakar dan memiliki lahan berada di sekitar lahan yang pernah terbakar. Pengumpulan data secara sensus terhadap 95 masyarakat tersebut. Metode analisis yang digunakan adalah secara statistik deskriptif dan statistik inferensial (Rank Spearman). Hasil penelitian menunjukkan tingkat partisipasi masyarakat dalam pencegahan kebakaran lahan sangat rendah. Hasil analisis rank spearman menunjukkan faktor yang berhubungan terhadap partisipasi adalah faktor eksternal, terdiri dari peran penyuluh dan dukungan lingkungan sosial (dukungan tokoh masyarakat, peran kelompok, media informasi dan peran pemerintah). Faktor internal yang berhubungan adalah tingkat pendidikan dan pendapatan. Partisipasi masyarakat agar meningkat diperlukan peran penyuluh yang merata dan peran aktif pemerintah untuk membina dan melatih sasaran yang tepat.
Kata kunci: lahan gambut, masyarakat, partisipasi, pencegahan kebakaran lahan
Analisis Persepsi Petani Terhadap Penggunaan Benih Bawang Merah Lokal dan Impor di Kabupaten Cirebon, Jawa Barat
Authors: Theresia Valentina , Fariyanti Anna , Tinaprilla Netti
Published: May 2017

Adanya keterbatasan produksi benih bawang merah nasional menyebabkan Indonesia belum mampu memenuhi kebutuhan benih nasional. Oleh karena itu Indonesia mengimpor benih bawang merah dari beberapa negara. Dengan hadirnya benih bawang merah impor, petani dihadapkan kepada suatu pilihan yaitu menggunakan benih lokal ataupun impor sedangkan pemilihan benih tidak terlepas dari persepsi petani terhadap varietas tersebut. Oleh karena itu penelitian ini bertujuan untuk menganalisis persepsi petani terhadap penggunaan benih bawang merah lokal dan impor serta keunggulan dari benih lokal dan impor. Metode analisis yang digunakan adalah analisis persepsi dengan teknik scoring dan dianalisis menggunakan metode rata-rata skor serta penggunaan teknik Perceptual Mapping dengan membuat grafik sarang laba-laba.Responden penelitian berjumlah 60 orang yang terdiri dari 30 petani pengguna benih bawang merah lokal dan 30 petani pengguna benih impor. Hasil penelitian menunjukkan bahwa persepsi petani pengguna benih bawang merah lokal dan impor terhadap benih bawang merah lokal tergolong baik, sedangkan persepsi petani pengguna benih bawang merah lokal dan impor terhadap penggunaan benih impor tergolong kurang baik. Secara keseluruhan persepsi petani terhadap benih lokal lebih baik dibandingkan dengan benih impor. Hal ini menunjukkan bahwa benih bawang merah lokal lebih memiliki banyak keunggulan dibandingkan dengan benih impor.
Kata kunci : persepsi, petani, bawang merah, benih lokal, benih impor