bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparison of the Dinosaur Communities from the Middle Jurassic of the Cleveland (Yorkshire) and Hebrides (Skye) Basins, Based on Their Ichnites
Authors: Romano Mike , Clark Neil D. L. , Brusatte Stephen L.
Published: August 2018

Despite the Hebrides and Cleveland basins being geographically close, research has not previously been carried out to determine faunal similarities and assess the possibility of links between the dinosaur populations. The palaeogeography of both areas during the Middle Jurassic shows that there were no elevated landmasses being eroded to produce conglomeratic material in the basins at that time. The low-lying landscape and connected shorelines may have provided connectivity between the two dinosaur populations. The dinosaur fauna of the Hebrides and Cleveland basins has been assessed based primarily on the abundant ichnites found in both areas as well as their skeletal remains. In the two basins the dinosaur faunas are very similar, consisting of non-neosauropod eusauropods, a possible basal titanosauriform, large and small theropods and ornithopods and europodan thyreophorans. The main difference in the faunas is in the sizes. In the Cleveland Basin the ichnites suggest that there were medium and large theropods alongside small to medium sized ornithopods whereas in the Hebrides Basin the theropods were from small to large and the ornithopods were medium to large. It is suggested that migrations could have taken place between the two areas during the Middle Jurassic. A tentative food chain from the herbivorous dinosaurs to the top predators can be inferred from the footprints.
Daylight Performance of a Translucent Textile Membrane Roof with Thermal Insulation
Authors: Gürlich Daniel , Reber Amando , Biesinger Andreas , Eicker Ursula
Published: August 2018

Daylight usage in buildings improves visual comfort and lowers the final energy demand for artificial lighting. The question always occurs: how much conservation can you achieve? New upcoming or rare materials and constructions have a lack of information about their application. Therefore, the current work investigates the daylight performance of a multi-layer textile membrane roof with 2 300 m² on top of a sports hall. A translucent, thermal insulation with a glass fibre fleece between the roof membranes combines daylight usage and heating demand reduction. A sports hall with built year 2017 is selected as the case study building. The optical properties of the roof construction are measured. The (visual) light transmittance amounts to 0.72 % with a clean surface. An accordingly parametrized climate-based annual daylight modeling delivers daylight indicators for different construction scenarios. The results show that in comparison to only one glass facade, the additional translucent and thermally insulated membrane construction increases the annual daylight autonomy700/ continuous DA700 from 0/ 15 % to 1.5/ 38 %. In the roof covered areas of the sport field, this results in a reduction from 19.7 to 13.8 kWhel/m²/a electricity for the artificial lighting with dim control (30 % savings). Also, the influence of soiling on the light transmittance was determined with a relevant reduction of one layer about a factor 0.81. The novel results are of great value as a comparison and benchmark for planners and future buildings of similar type.
Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats
Authors: Huang Ying Che , Wu Bo-Hua , Chu Yung-Lin , Chang Wen-Chang , Wu Ming-Chang
Published: August 2018

The increased consumption of high fat-containing foods has been linked to the prevalence of obesity and abnormal metabolic syndromes. Rhizopus oligosporus, a fungus in the family Mucoraceae, is widely used as a starter for homemade tempeh. Although R. oligosporus can prevent the growth of other microorganisms, it grows well with lactic acid bacteria (LAB). Lactobacillus plantarum can produce β-glucosidase, which catalyzes the hydrolysis of glucoside isoflavones into aglycones (with greater bioavailability). Therefore, the development of a soybean-based functional food by the co-inoculation of R. oligosporus and L. plantarum is a promising approach to increase the bioactivity of tempeh. In this study, the ameliorative effect of L. plantarum in soy tempeh on abnormal carbohydrate metabolism in high-fat diet (HFD)-induced hyperglycemic rats was evaluated. The co-incubation of L. plantarum with R. oligosporus during soy tempeh fermentation reduced the homeostatic model assessment of insulin resistance, HbA1c, serum glucose, total cholesterol, triglyceride, free fatty acid, insulin, and low-density lipoprotein contents and significantly increased the high-density lipoprotein content in HFD rats. It also increased the LAB counts as well as the bile acid, cholesterol, triglyceride, and short-chain fatty acid contents in the feces of HFD rats. Our results suggested that the modulation of serum glucose and lipid levels by LAB occurs via alterations in the internal microbiota, leading to the inhibition of cholesterol synthesis and promotion of lipolysis. Tempeh, produced with both L. plantarum and R. oligosporus, may be a beneficial dietary supplement for individuals with abnormal carbohydrate metabolism.
Analysis of Bearing Capacity of Helical Pile with Hexagon Joints
Authors: Kim Daehyeon , Baek Kyemoon , Park Kyungho
Published: August 2018

This study aims to improve the shaft with hexagon joints to be a type not requiring welding or bolts in the static load test . In order to evaluate the bearing capacity of helical piles, two sites were selected to conduct pile installation for the field test and the pile load test. For the pile load test, the static pile load test and the dynamic pile load test were carried out, and torque was measured during pile installation for the field test to compare and analyze expected bearing capacity and thus assess the feasibility of the method for estimating the bearing capacity. The field pile load test revealed the bearing capacity of the gravity grout pile was the same or greater than 600kN in the static pile load test in accordance with AC 358 Code. The non-grout pile showed the bearing capacity the same or smaller than 600kN, suggesting gravity grouting is required. Moreover, the field pile load test was used to establish the bearing capacity equation considering the torque in pile installation, and a small number of samples were used to establish the equation which can be used as a basic data.
Recent Progress on the Fabrication of Silver Nanowire-Based Transparent Electrodes
Authors: Zhang Renyun , Engholm Magnus
Published: August 2018

Transparent electrodes (TEs) made of metallic nanowires, such as Ag, Au, Cu, and Ni, have attracted rising attention for several reasons: 1) they can act as a substitute for tin oxide-based TEs such as indium-tin oxide (ITO) and fluorine-doped tin oxide (FTO); 2) various methods exist for fabricating such TEs such as filtration, spraying and meyer bar coating; 3) greater compatibility with different substrates can be achieved due to the variety of fabrication methods; and 4) extra functions in addition to serving as electrodes, such as catalytic abilities, can be obtained due to the metals that compose the TEs. There are a large number of applications for TEs, ranging from electronics and sensors to biomedical devices. This short review is a summary of recent progress, mainly during the past five years, on silver nanowire-based TEs. The focus of the review will be on theory development, mechanical, chemical and thermal stability and optical properties. The many applications of TEs are outside the scope of this review.
Designing an Intuitive Driving Experience in a Digital World
Authors: KUOCH Siav-Kuong , Nowakowski Christopher , Hottelart Katharina , Reilhac Patrice , Escrieut Pierre
Published: August 2018

As we approach the 135th anniversary of the automobile, two industry trends, automation and digitalization, are rapidly revolutionizing the thus far, relatively unchanged automotive user experience. This paper describes the development of the Valeo MyMobius user interface concept. The goal of this project was to explore how to achieve an intuitive driving experience as the automotive industry undergoes transition from primarily analog to primarily digital interfaces and from physical buttons to multimodal interactions. To achieve the perception of intuitiveness, designers must understand their users, find and reduce physical and cognitive friction points, and bridge knowledge gaps with interface designs that facilitate discovery and learnability. The Valeo MyMobius concept featured steering wheel touch displays that supported quick, frequent menu selections using swiping gestures (common in smartphone interactions) and reinforcing icons (to facilitate learnability). Learning algorithms personalized the experience by tailoring suggestions, while more complex interactions were handled with a conversational voice assistant, which also served as a driving copilot, capable of contextually suggesting when Advanced Driving Assistance System (ADAS) features such as ACC could be utilized. The visual design aesthetic embodied Kenya Hara’s design philosophy of “Emptiness,” reducing visual clutter and creating spaces that are ready to receive inspiration and information. Altogether, the Valeo MyMobius concept demonstrated an attainable future where the perception of intuitiveness can be achieved with today’s technologies.
Mathematical and Experimental Research of the Shopping Centers’ Managers’ Strategic Behavior
Authors: Alekseev Aleksandr , Spirina Varvara , Andronova Aleksandra
Published: August 2018

The managers’ strategic behavior of commercial real estate in a competitive environment is discussed. The means of this research are methods of mathematical and experimental game theory. Illustrates an example of a decision-theoretic game problem with two players engaged in the management of competing shopping centers. The strategies of these players are determined by the costs of the development. Since the number of visitors is constantly and changing the quality of shopping centers, managers actually pull visitors from each other, the game-theoretical formulation of the problem of management of shopping centers corresponds to the zero-sum game. The model example shows that with the help of mathematical modeling it is possible to determine the theoretical expected behavior of agents. The model of the software module created specifically for experimental research is described. The experiments are designed to compare the theoretically predicted behavior with the real actions of people. The novelty is that at significant costs of the Manager for the development and promotion of shopping and entertainment centers, the strategies of managers are resistant to each other's actions, in contrast to changes in the external environment is shown.
Defining Benefits and Detecting Future Challenges of Digitalizing Distribution Network Substations
Authors: Jurišić Goran , Havelka Juraj , Capuder Tomislav , Sučić Stjepan
Published: August 2018

With the introduction of the IEC 61850 standard, the path is set for a single communication topology covering all substation levels. The standard has the potential to change the way substations are designed, build, tested and maintained. This means that the key segment of the substation, its protection system, will go through a transition period with the end goal of having a digitalized substation where all information exchange is performed over an Ethernet communication bus. The goal of this paper is to analyse the performance impact of the IEC 61850-9-2LE on the protection system. To do this, a laboratory hardware-in-the-loop test setup is developed representing traditional, hybrid and digital substation topology. This setup served to simulate faults and create transient waveforms in an extended IEEE 123 node test system, which were then used to detect the reaction times of protection relay devices. To verify protection relay results significant number of tests are performed clearly showing benefits which can be gained by distribution system digitalization.
Coefficient-of-Determination Discrete Fourier Transform
Authors: Marko Matthew
Published: August 2018

This algorithm is designed to perform Discrete Fourier Transforms (DFT) to convert temporal data into spectral data. This algorithm obtains the Fourier Transforms by studying the Coefficient of Determination of a series of artificial sinusoidal functions with the temporal data, and normalizing the variance data into a high-resolution spectral representation of the time-domain data with a finite sampling rate. What is especially beneficial about this DFT algorithm is that it can produce spectral data at any user-defined resolution.
Almost Fully Secure Lattice-Based Group Signatures with Verifier-Local Revocation
Authors: Perera Maharage Nisanasla Sevwandi , Koshiba Takeshi
Published: August 2018

Efficient member revocation and strong security against attacks are prominent requirements in group signature schemes. Among the revocation approaches Verifier-local revocation is the most flexible and efficient method since it requires to inform only the verifiers regarding the revoked members. The verifier-local revocation technique uses a token system to manage members’ status. However, the existing group signature schemes with verifier-local revocability rely on weaker security. On the other hand, existing static group signature schemes rely on a stronger security notion called, full-anonymity. Achieving the full-anonymity for group signature schemes with verifier-local revocation is a quite challenging task. This paper aims to obtain stronger security for the lattice-based group signature schemes with verifier-local revocability, which is closer to the full-anonymity. Moreover, this paper delivers a new key-generation method which outputs revocation tokens without deriving from the users’ signing keys. By applying the tracing algorithm given in group signature schemes for static groups, this paper also outputs an efficient tracing mechanism. Thus, we deliver a new group signature scheme with verifier-local revocation that satisfies a stronger security from lattices.
Clinical Utility of Expanded Carrier Screening: Results-Guided Actionability and Outcomes
Authors: Johansen Taber Katherine , Beauchamp Kyle A. , Lazarin Gabriel , Muzzey Dale , Arjunan Aishwarya , Goldberg James D.
Published: August 2018

Purpose: Expanded carrier screening (ECS) informs couples of their risk of having offspring affected by certain genetic conditions. Limited data exists assessing the actions and reproductive outcomes of at-risk couples (ARCs). We describe the impact of ECS on planned and actual pregnancy management in the largest sample of ARCs studied to date. Methods: Couples who elected ECS and were found to be at high risk of having a pregnancy affected by at least one of 176 genetic conditions were invited to complete a survey about their actions and pregnancy management. Results: Three hundred ninety-one ARCs completed the survey. Among those screened before becoming pregnant, 77% planned or pursued actions to avoid having affected offspring. Among those screened during pregnancy, 37% elected prenatal diagnostic testing (PNDx) for that pregnancy. In subsequent pregnancies that occurred in both the preconception and prenatal screening groups, PNDx was pursued in 29%. The decision to decline PNDx was most frequently based on the fear of procedure-related miscarriage, as well as the belief that termination would not be pursued in the event of a positive diagnosis. Conclusions: ECS results impacted couples’ reproductive decision-making and led to altered pregnancy management that effectively eliminates the risk of having affected offspring.
The Hedgehog Signaling Pathway in the Ischemic Heart, Brain, and Skeletal Muscle
Authors: Giarretta Igor , Gaetani Eleonora , Tondi Paolo , Asahara Takayuki , Pola Roberto
Published: August 2018

Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in ischemic condition is also presented.
A Shear Reynolds Number Based Investigation Method of the Bed Load Transport in Large Rivers with Complex Morphodynamics
Authors: Török Gergely T. , Józsa János , Baranya Sándor
Published: August 2018

The aim of this study is to introduce a novel method which can separate sand or gravel dominated bed load transport in rivers with mixed-size bed material. In engineering practice, the Shields-Parker diagram could be used for such purposes, however, the method has certain applicability limits, due to the fact that it is based on uniform bed material and provides information rather on river-scale, instead of reach or local scale. When dealing with large rivers with complex hydrodynamics and morphodynamics the bed load transport modes can also indicate strong variation even locally, which requires a more suitable approach to estimate the locally unique behavior of the sediment transport. Here, we suggest that the decision criteria utilizes the shear Reynolds number (Re*). The method was verified against field and laboratory measurement data, both performed at non-uniform bed material compositions. The comparative assessment of the results show that the shear Reynolds number based method operates more reliably than the Shields-Parker diagram and it is expected to predict the sand or gravel transport domination with a < 5% uncertainty. The introduced results can greatly contribute to the improvement of numerical sediment transport modeling as well as to the field implementation of bed load transport measurements.
Improved Immune Responses against Zika Virus after Sequential Dengue and Zika Virus Infection in Human
Authors: Delgado Felix G. , Torres Karina I. , Castellanos Jaime E. , Romero-Sánchez Consuelo , Simon-Lorière Etienne , Sakuntabhai Anavaj , Roth Claude
Published: August 2018

The high level of dengue virus (DENV) seroprevalence in areas where Zika virus (ZIKV) is circulating and the cross-reactivity between these two viruses have raised concerns on the risk of increased ZIKV disease severity for patients with a history of previous DENV infection. To determine the role of DENV pre-immunity in ZIKV infection, we analysed the T and B cell responses against ZIKV in donors with or without previous DENV infection. Using PBMCs from donors living in an endemic area in Colombia, we have identified, by interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) assay, most of the immunodominant ZIKV T-cell epitopes in the non-structural proteins NS1, NS3 and NS5. Analyses of the T and B-cell responses in the same donors revealed a stronger T-cell response against peptides conserved between DENV and ZIKV, with a higher level of ZIKV-neutralizing antibodies in DENV-immune donors, in comparison with DENV-naïve donors. Strikingly, the potential for antibody mediated enhancement of ZIKV infection was reduced in donors with sequential DENV and ZIKV infection in comparison with donors with DENV infection only. Altogether, these data suggest that individuals with DENV immunity present improved immune responses against ZIKV.
An Android Mutation Malware Detection Based on Deep Learning Using Visualization of Importance from Codes
Authors: Yen Yao-Saint , Sun Hung-Min
Published: August 2018

Using smartphone especially android platform has already got eighty percent market shares, due to aforementioned report, it becomes attacker’s primary goal. There is a growing number of private data onto smart phones and low safety defense measure, attackers can use multiple way to launch and to attack user’s smartphones.(e.g. Using different coding style to confuse the software of detecting malware). Existing android malware detection methods use multiple features, like safety sensor API, system call, control flow structure and data information flow, then using machine learning to check whether its malware or not. These feature provide app’s unique property and limitation, that is to say, from some perspectives it might suit for some specific attack, but wouldn’t suit for others. Nowadays most malware detection methods use only one aforementioned feature, and these methods mostly analysis to detect code, but facing the influence of malware’s code confusion and zero-day attack, aforementioned feature extraction method may cause wrong judge. So, it’s necessary to design an effective technique analysis to prevent malware. In this paper, we use the importance of word from apk, because of code confusion, some malware attackers only rename variables, if using general static analysis wouldn’t judge correctly, then use these importance value to go through our proposed method to generate picture, finally using convolutional neural network to see whether the apk file is malware or not.
Spatial Organization of Five-Fold Morphology as a Source of Geometrical Constraint in Biology
Authors: López-Sauceda Juan , López-Ortega Jorge , Sandoval Gutiérrez Jacobo , Laguna Sánchez Gerardo Abel , Rojas Meza Ana Paola , Aragón Vera José Luis
Published: August 2018

A basic pattern in the body plan architecture of many animals, plants and some molecular and cellular systems is five-part units. This pattern has been understood as a result of genetic blueprints in development and as a widely conserved evolutionary character. Despite some efforts, a definitive explanation of the abundance of pentagonal symmetry at so many levels of complexity is still missing. Based on both, a computational platform and a statistical spatial organization argument, we show that five-fold morphology is substantially different from other abundant symmetries like three-fold, four-fold and six-fold symmetries in terms of spatial interacting elements. We develop a measuring system to determine levels of spatial organization in 2D polygons (homogeneous or heterogeneous partition of defined areas) based in principles of regularity in a morphospace. We found that spatial organization of five-fold symmetry is statistically higher than all other symmetries studied here (three to ten-fold symmetries) in terms of spatial homogeneity. The significance of our findings is based on the statistical constancy of geometrical constraints derived from spatial organization of shapes, beyond the material or complexity level of the many different systems where pentagonal symmetry occurs.
Analysis of a second order thermodynamic model for the performance analysis of a Stirling engine prototype
Authors: Torres García Miguel , Carvajal Trujillo Elisa , Vélez Godiño José Antonio , Sánchez Martínez David
Published: August 2018

The Stirling engine is a simple type of external-combustion engine with an external combustion engine based on cyclic compression and expansion of gas at different temperature levels. It has high efficiency; low vibration levels, simple structure and can run on any combustible fuels. It has been the object of numerous studies. This paper presents an analysis of a Stirling engine model GENOA 03 for electric power generation, of 3 KW of nominal power with pressurized air as working fluid, currently under development.
To improve its performance and ensure a good operational reliability, it is necessary to carry out a modelling of the engine in all its operating range. This requires complex numerical models that simulate the behaviour of any element of the engine in a cycle. Two typologies of thermodynamic models are developed in this work: isothermal and adiabatic. The main benefits and shortcomings of each model are mentioned. The geometry and conditions of the engine have been adapted through the Matlab ® tool, in order to obtain the operative conditions of the cooler that you want to replace, as well as an approximation to the expected behaviour.
CFD Analysis of Twin Turbulent Impinging Axisymmetric Jets at Different Impingement Angles
Authors: Gopalakrishnan Raj Narayan , Disimile Peter J
Published: August 2018

Based on the insight gained from single jet analysis performed earlier [1], CFD analysis on turbulent jets impinging on one another at an angle was performed. Multiple impingement angles were considered for this study to gain better understanding of the parameters affecting resultant jet growth and velocity distribution. From the study of single jet, it was concluded that the SST k-ω turbulence model was the ideal turbulence model capable of accurately predicting the flow physics of the jets exiting a fully developed pipe at low Reynolds number. Hence, for the study of impinging jets, SST k-ω turbulence model was used to study the velocity and jet growth characteristics. It became evident that the mesh alignment with the velocity vector at exit of the pipe domain plays a crucial role in the accuracy of the results. The parameter used to evaluate this condition was identified as False Diffusion and was observed to affect the TKE parameter significantly. Methods to reduce false diffusion are also discussed in this article. Based on the mesh obtained from the grid sensitivity study, jets impinging at 30, 45 and 60 degrees at Reynolds number of 7500 were numerically analyzed. It was observed that the profile of the resultant jet closely matched with the prediction of elliptical profile predicted by past researchers, [2] and [3]. Also, it was seen that higher jet growth was predicted in case of jets impinging at a higher impingement angle.
Simulating the Impact of the Internal Structure of Phytoplankton on the Bulk Particulate Backscattering Ratio using a Two-Layered Spherical Geometry for Cells
Authors: Duforêt-Gaurier Lucile , Dessailly David , Moutier William , Loisel Hubert
Published: August 2018

The bulk backscattering ratio ($\tilde{b_{bp}}$) is commonly used as a descriptor of the bulk real refractive index of the particulate assemblage in natural waters. Based on numerical simulations, we analyze the impact of heterogeneity of phytoplankton cells on $\tilde{b_{bp}}$. $\tilde{b_{bp}}$ is modeled considering viruses, heterotrophic bacteria, phytoplankton, detritus, and minerals. Three study cases are defined according to the relative abundance of these different components. Two study cases represent typical situations in open ocean, outside (No-B/No-M) and inside bloom (B/No-M). The third study case is typical of coastal waters with the presence of minerals. Phytoplankton cells are modeled by a two-layered spherical geometry representing a chloroplast surrounding the cytoplasm. The $\tilde{b_{bp}}$ values are higher when heterogeneity is considered because the contribution of coated spheres to backscattering is higher than homogeneous spheres. The impact of heterogeneity is however strongly conditioned by the hyperbolic slope $\xi$ of the particle size distribution. Even if the relative concentration of phytoplankton is small (<1%), $\tilde{b_{bp}}$ increases by about 60% (for $\xi=4.3$ and for the No-B/No-M water body), when the heterogeneity is taken into account, in comparison with a particulate population only composed by homogeneous spheres. As expected, heterogeneity has a much smaller impact (about 5$\%$ for $\xi=4.3$) on $\tilde{b_{bp}}$ when minerals are added.
A Review on Non-Pharmacological Treatments for Pain Management in Newborn Infants
Authors: Mangat Avneet K. , Oei Ju-Lee , Chen Kerry , Quah-Smith Im , Schmölzer Georg M.
Published: August 2018

Pain is a major problem in sick newborn infants, especially for those needing intensive care. Pharmacological pain relief is the most commonly used but may be ineffective, have side effects, including long-term neurodevelopmental sequelae. The effectiveness and safety of alternative analgesic methods are ambiguous. The objective is to review the effectiveness and safety of non-pharmacological methods of pain relief in newborn infants and to identify those that are the most effective. PubMed and Google Scholar were searched using the terms: ‘infant’, ‘premature’, ‘pain’, ‘acupuncture’, ‘skin to skin contact’, ‘sucrose’ ‘massage’, ‘musical therapy’ and ‘breastfeeding’. We included 24 studies assessing different methods of non-pharmacological analgesic techniques. Most resulted in some degree of analgesia but many were ineffective and some were even detrimental. Sucrose, for example, was often ineffective but more effective than music therapy, massage, breast milk (for extremely premature infants) or non-invasive electrical stimulation acupuncture. There were also conflicting results for acupuncture, skin to skin care and musical therapy. Most non-pharmacological methods of analgesia provide some modicum of relief for preterm infants but none are completely effective and there is no clearly superior method. Study is also required to assess potential long-term consequences of any of these methods.
Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model
Authors: Plakkal Janeesh A. , Lizardo Kezia , Wang Sean , Yurkow Edward , Nagajyothi Jyothi F.
Published: August 2018

Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice. In the present study, we examined whether treating infected mice with an ER stress inhibitor can modify the pathogenesis of cardiomyopathy during chronic stages of infection. T. cruzi infected mice were treated with an ER stress inhibitor 2-Aminopurine (2AP) during the indeterminate stage and evaluated for cardiac pathophysiology during the subsequent chronic stage. Our study demonstrates that inhibition of ER stress improves cardiac pathology caused by T. cruzi infection by reducing ER stress and downstream signaling of phosphorylated eukaryotic initiation factor (P-elF2α) in the hearts of chronically infected mice. Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients.
Interlaminar Shear Behavior of Laminated Carbon Fiber Reinforced Plastic from Microscale Strain Distributions Measured by Sampling Moire Technique
Authors: Wang Qinghua , RI Shien , Tsuda Hiroshi , Takashita Yosuke , Kitamura Ryuta , Ogihara Shinji
Published: August 2018

The interlaminar shear behavior of a [±45°] laminated carbon fiber reinforced plastic (CFRP) specimen was investigated utilizing microscale strain mapping in a wide field of view. A three-point bending device was developed under a laser scanning microscope, and the full-field strain distributions including normal, shear and principal strains of CFRP in a three-point bending test were measured using a developed sampling Moire technique. The microscale shear strain concentrations at interfaces between each two adjacent layers were successfully detected and found to be positive-negative alternately distributed before damage occurrence. The 45° layers slipped to the right relative to the -45° layers, visualized from the revised Moire phases and shear strain distributions of the angle-ply CFRP under different loads. The absolute values of the shear strain at interfaces gradually rose with the increase of the bending load, and the sudden decrease of the shear strain peak value implied the occurrence of interlaminar damage. The evolution of the shear strain concentrations is useful in the quantitative evaluation of the potential interlaminar shear failure.
Mesoscale Resolution Radar Data Assimilation Experiments with the Harmonie Model
Authors: Ivanov Serguei , Michaelides Silas , Ruban Igor
Published: August 2018

This study presents a pre-processing approach adopted for the radar reflectivity data assimilation and results of simulations with the Harmonie numerical weather prediction model. The method shows an improvement of precipitation prediction within the radar location area in both the rain rates and spatial pattern presentation. With the assimilation of radar data, the model simulates larger water content in the middle troposphere within the layer from 1 to 6 km, with major variations at 2.5–3 km; it also reproduces better the mesoscale belt and cell patterns of precipitation fields.
Experimental Investigation of Impact Detection and Damage Extent Quantification
Authors: Faisal Haider Mohammad , Migot Asaad , Bhuiyan Md Yeasin , Giurgiutiu Victor
Published: August 2018

This paper focused on impact localization of composite structures, which possess more complexity in the guided wave propagation because of the anisotropic behavior of composite materials. In this work, a composite plate was manufactured by using a compression molding process with proper pressure and temperature cycle. Eight layers of woven composite prepreg were used to make the plate. A structural health monitoring (SHM) technique is implemented with piezoelectric wafer active sensors (PWAS) to detect and localize the impact on the plate. There are two types of impact event are considered in this paper (a) low energy impact event (b) high energy impact event. Two clusters of sensors recorded the guided acoustic waves generated from the impact. The acoustic signals are then analyzed using a wavelet transform based time-frequency analysis. The proposed SHM technique successfully detect and localize the impact event on the plate. The experimentally measured impact locations are compared with the actual impact locations. An immersion ultrasonic scanning method was used to visualize the composite plate before and after the impact event. A high frequency 10 MHz 1-inch focused transducer was used to scan the plate in an immersion tank. Scanning results show that there is no visible manufacturing damage in the composite plate. However, clear impact damage was observed after the high-energy impact event.
Selenium-Related Transcriptional Regulation of Gene Expression
Authors: Lammi Mikko J. , Qu Chengjuan
Published: August 2018

Selenium is a trace metal essential to human health, and its deficiency has been related to, for instance, cardiovascular and myodegenerative diseases, infertility and osteochondropathy Kashin-Beck disease. It is incorporated as selenocysteine to selenoproteins, which protect against reactive oxygen and nitrogen species. They also participate in the activation of thyroid hormone, and play a role in immune system functioning. The synthesis and incorporation of selenocysteine occurs via a special mechanism, which differs from the one used for standard amino acids. The codon for selenocysteine is the regular in-frame stop codon, which can be passed by specific complex machinery participating in translation elongation and termination. This includes the presence of selenocysteine insertion sequence (SECIS) in the 3’-untranslated part of the selenoprotein mRNAs. Selenium deficiency is known to control both selenoprotein and non-selenoprotein transcriptomes. Nonsense-mediated decay is involved in the regulation of selenoprotein mRNA levels, both other mechanisms are also possible.
Osteonecrosis After Contralateral in Situ Prophylactic Pinning for a Slipped Capital Femoral Epiphysis
Authors: Chargui Moez , Dhouib Amira , Esposito Fabiana , Spyropoulou Vasiliki , Steiger Christina , Dayer Romain , Ceroni Dimitri
Published: August 2018

Case:

We report the case of an 11-year-old girl who developed osteonecrosis of the femoral head in the radiographically normal, asymptomatic left hip that had been fixed prophylactically in the context of a slipped capital femoral epiphysis (SCFE) that had been detected on the contralateral hip. The etiology of the osteonecrosis remains unknown.

Conclusion:

This case report demonstrates that prophylactic fixation of a radiographically normal, asymptomatic hip in the context of an SCFE on the contralateral side has the potential for substantial complications. Therefore, the risk of osteonecrosis in the prophylactically pinned hip should be carefully considered because this complication may have devastating functional consequences.
Pacemaker Lead Dislodgement Due to Left Shoulder Dislocation
Authors: Kawai Momotaro , Tanji Atsushi , Nishijima Takayuki , Tateyama Koichi , Kamata Yusaku , Urabe Tadahisa
Published: August 2018

Case:

A 63-year-old man with a cardiac pacemaker presented with a left shoulder dislocation. His heart rate was 46 beats per minute, and pacemaker testing demonstrated an elevated pacing threshold, a decreased sensing threshold, and stable pacemaker lead impedance. Lead dislodgement due to the shoulder dislocation was suspected, and the patient underwent repositioning of the lead.

Conclusion:

When a patient with a pacemaker dislocates a shoulder, it should be confirmed that the heart rate is above the programmed lower rate of the pacemaker; electrocardiography should be performed, and the pacing parameters should be checked to ensure that pacing failure is not overlooked.
Shoulder Arthroplasty Outcomes After Prior Non-Arthroplasty Shoulder Surgery
Authors: Frank Rachel M. , Lee Simon , Sumner Shelby , Griffin Justin , Leroux Timothy , Verma Nikhil N. , Cole Brian J. , Nicholson Gregory P. , Romeo Anthony A.
Published: August 2018

Background:

The purpose of this retrospective study was to compare outcomes and complications in patients with and patients without a history of non-arthroplasty surgery on the ipsilateral shoulder who later underwent total shoulder arthroplasty (TSA) or reverse total shoulder arthroplasty (RTSA). We hypothesized that patients who had undergone prior surgery would have more complications and worse clinical outcomes.

Methods:

Consecutive patients who had undergone shoulder arthroplasty and had been followed for a minimum of 2 years were evaluated with the American Shoulder and Elbow Society scoring system (ASES), Simple Shoulder Test (SST), and Visual Analog Scale (VAS) assessments and with physical examination, including range-of motion assessments. Complications and outcomes in patients who had undergone prior surgery on the ipsilateral shoulder (PS group) were compared with those in patients without such a history (NPS group).

Results:

Data on 506 shoulder arthroplasties (263 TSA and 243 RTSA) were available for analysis. A total of 144 patients (28%) had an average of 1.9 ± 1.0 surgical procedures on the ipsilateral shoulder before arthroplasty. The average age in the PS group was significantly younger at the time of arthroplasty compared with the NPS group (61.6 ± 10.2 years compared with 68.2 ± 8.6 years, p = 0.035). At an average follow-up of 42.8 ± 16.4 months, both groups had significant improvements in ASES, SST, VAS, and range-of-motion values (p < 0.05 for all). All outcome scores in the PS group were significantly lower than those in the NPS group (p < 0.001 for all). The PS group also had a significantly higher complication rate than the NPS group (19.4% compared with 4.4%, p < 0.001), and multivariate regression analysis revealed that prior surgery was a significant independent predictor of postoperative complications. There were no differences between the PS and NPS groups in the number of postoperative infections (p = 0.679), reoperations (p = 0.553), or transfusions (p = 0.220).

Conclusions:

Patients who have a history of prior surgery on the ipsilateral shoulder derive benefit from shoulder arthroplasty, but their magnitude of improvement and final scores are lower than those of patients who do not have such a history. This information can be used to counsel this challenging patient population on expected outcomes following shoulder arthroplasty.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Innovative aspects of budgeting and internal control in regional economy
Authors: Menshikova M. A. , Fedotov A. V.
Published: August 2018

In article innovative aspects of forming of the management system meeting the requirements and features of the regional industry entities are stated. The functioning model business of processes of regional industrial enterprise is considered. The budgeting system in the conditions of process management, and also a form and instruments of control is recommended.
Public audit of efficiency of sustainable development of public corporations: the development of
Authors: Nikiforova E. V. , Alibekova В. А.
Published: August 2018

The article describes the main directions of the state audit of the sustainability of public corporations. Comparative characteristics of the essence and importance of state audit in the Russian Federation and the Republic of Kazakhstan. The primary objective of the state audit sustainability audit is the efficient use of public resources in terms of preservation and increment of state ownership. This goal is defined in the legislation of the Russian Federation and the Republic of Kazakhstan. In the legislation of these countries focuses on improving the efficiency of management and use of budget funds, state assets and public sector entities.
The formation of the information accounting system of the business entity
Authors: Popova L. V. , Maslova I. A. , Dedkova E. G.
Published: August 2018

The article justified the urgency and benefits of developing accounting and control systems in the enterprise. Presents the author's vision of the entity and item content information accounting and control system at the level of the entity. Defines the function of the components of information accounting and control system, the implementation of which allows to form the array of analytical data necessary for the development and management decisions.
The impact of global processes on gold mining in Russian Federation
Authors: Vorontsov Ya. N.
Published: August 2018

The article considers the likely impact of global processes on gold mining in Russian Federation.
Influence of scientific and educational potential of innovation development of the region
Authors: Potasheva O. V. , Tishkov S. V.
Published: August 2018

This article is devoted to the formation and development of scientific and educational potential and their role in innovation development of the region. It is necessary to distinguish the economic factor, i.e. the readiness of the region for development of investment activity and creation of conditions of fixing of the most important factors influencing the quality of professional formation of educational potential of the population of the region in the area of young professionals. It is shown that an important component of the innovation potential of the region is its scientific potential.
The system of financial controlling of industrial enterprises
Authors: Bobkova M. P.
Published: August 2018

In the article examined the peculiarities of the system of financial controlling in an industrial enterprise: the necessity of developing goal system, objectives, requirements for information system support.
The use of Data Mining methods to assess the reliability of bank lending borrowers
Authors: Sidorova N. P.
Published: August 2018

Estimates of credit banking risk is one of the topical tasks of banking. Correct and timely assessment of the reliability of the bank's customers who applied for the loan will help reduce the bank's losses associated with credit risks. To increase the efficiency and validity of making decisions on the issuance of a loan, Data Mining methods can be used. The article considers Data Mining technologies, which are applicable for the implementation of the scoring method of the borrower's assessment.
Accounting and analytical aspects of the value of human capital of the enterprise
Authors: Linev A. I.
Published: August 2018

Object. Modern business - is highly complex, constantly changing system that requires a deep rethinking and measurement. The success and stability in business development comes only to those enterprises, which realized, develop and implement innovative projects. At the same time rely on individual intellectual development worker to the enterprise is not necessary, a reference to this situation is the implementation of innovative projects requiring «intelligent enterprise». Intelligent Enterprise - is a technologically advanced information and an enterprise carried on by a competent, highly skilled and highly educated personnel. Subject. The relevance of the article due to the fact that human capital is an important resource activities of any business entity. Goal. Author's research is aimed at studying accounting and analytical aspects of an enterprise value of human capital at the present time. Development of a qualitatively new approach to the problem focused on «intelligent enterprise». The main feature of «intelligent enterprise» - the company's market capitalization in excess of the book value of its resources. Methodology. The study challenges the registration-analytical aspects of human capital value of the enterprise used the methods of morphological analysis, typologies, techniques logistic data link, the system analysis. Results. There is a problem of underestimating the intellectual potential of the enterprise. Practice has proved that the complexity of assessing the market value of any company in the transaction of purchase and sale is caused by the fact that the market value of most companies is different from the book value. This is due to the fact that most businesses are not able to reliably estimate their intellectual assets, ie the value of human capital. Scope of the study results. All sectors of activity. Conclusions. Proper and adequate assessment of the value of the company is necessary as external stakeholders (the formation of its value), as well as with internal stakeholders (effective management). This problem is solved provided reliable accounting and reflection of human capital (intellectual potential).
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Authors: Vikulina E. V.
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Most number of houses today are run by management companies that are engaged in a wide range of issues: welfare of owners of housing and communal services, carrying out flowing and major repairs, etc., so accounting and tax accounting in the management of the company has a number of features that need to be considered in the implementation of financial and economic activities.
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Authors: Melnikov A. Ye.
Published: August 2018

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