bluuebunny/crossref_metadata_2025 huggingface dataset:
Os muiraquitãs das estearias do Lago Cajari depositados no Museu Nacional (RJ)
Authors: Prous André , Navarro Alexandre Guida
Published: August 2020

Os muiraquitãs são artefatos confeccionados, em geral, por nefrita verde, associados, especialmente, às culturas arqueológicas das áreas de confluência dos rios Tapajós-Nhamundá-Trombetas. Estes objetos são vinculados à Tradição Inciso-Ponteada e aos falantes dos grupos Karib. Este artigo debruça-se nos dois muiraquitãs encontrados nas estearias do Lago Cajari, Baixada Maranhense, pelo geógrafo Raimundo Lopes entre 1919 e 1940, hoje desaparecidos por causa do incêndio que destruiu o Museu Nacional (RJ) em 2018. A partir da descrição tecnológica das peças, da análise simbólica e da evidência etno-histórica, conclui-se que os muiraquitãs das estearias foram importados do Baixo Amazonas, através de trocas entre grupos vizinhos, indicando uma circulação de bens de prestígio e certa interação social a partir do simbolismo destas pedras verdes.
Espelho ou tímpano?
Authors: Vergara Cerqueira Fábio
Published: August 2020

Analisa-se aqui uma oinochoe ápula, conservada em Varsóvia, produzida no final da técnica de figuras vermelhas, c. 300 a.C, e próxima do Pintor de Mignot, de um grupo muito tardio de pintores, em que a técnica colapsara. Sua iconografia singular se destaca devido ao objeto circular na mão da figura feminina, identificado como espelho (κάτοπτρον) ou tympanon (τύμπανον). Realizamos um exercício de interpretação, discutindo aspectos passíveis de análise iconográfica, comparando a pintura de vasos ática e italiota. Concluímos: o objeto circular não é compatível com um tympanon, mas sim como um espelho — espelho especial, místico, ligado ao culto a Eros, importante no séc. IV a.C. na Itália meridional, em que o espelho desempenhava um papel místico.
O petyn no cachimbo branco
Authors: Hissa Sarah de Barros Viana
Published: August 2020

O uso do tabaco, hábito adquirido dos nativos e ressignificado ao longo dos séculos, foi prática quase ubíqua entre luso-brasileiros desde a implantação da colônia. Essa tese, que recebeu o Prêmio SAB Excelência pela Sociedade de Arqueologia Brasileira (1ª edição/2019), enfatiza o fumo e cachimbos, notadamente os importados, no passado histórico.
SIÇANLARDA SİMVASTATİN UYGULAMASI İLE OLUŞAN ANKSİYOJENİK-BENZERİ DAVRANIŞTA NİTRİK OKSİTİN ETKİSİ
Authors: ALKANAT Mehmet , ÖZDEMİR Hafize , BAYTAN Şükrücan
Published: August 2020

Amaç: 3-hidroksi-3-metil-glutaril-koenzim A redüktaz enzimini inhibe ederek kolesterol sentezini engelleyen statinler tüm dünyada hiperlipidemilerin tedavisinde yaygın olarak kullanılmaktadır. Statin ailesinin önemli bir üyesi olan simvastatinin, çeşitli çalışmalarda nitrik oksit miktarını arttırdığı gösterilmiştir. Bu çalışmada, simvastatin kullanımına bağlı olarak değişen anksiyete seviyesine, nitrik oksit düzeyinin etki edip etmediği araştırıldı.Gereç ve Yöntemler: Sprague-Dawley cinsi sıçanlardan, her grupta 8 denek olmak üzere, 7 grupta deneklerin anksiyete düzeyinin gözlenmesi için yükseltilmiş artı labirent ve açık alan testi uygulandı. Çözücü grubuna fosfat tamponlu çözelti uygulanırken, yalnızca simvastatin alan gruba 20 ve 40 mg/kg dozda simvastatin uygulandı. Diğer iki gruptaki deneklere 20 mg/kg simvastatine ek olarak 10 mg/kg L-NAME, diğer gruba ise 50mg/kg L-NAME uygulandı. Kalan son iki gruba 40 mg/kg simvastatin ile 10 ve 50 mg/kg L-NAME dozları uygulandı. Çözücü ve ilaç uygulamasının 1, 4, 7, 10, 15, 21 ve 28. günlerinde tüm gruplar test edildi. Yükseltilmiş artı labirent kapalı kolda kalma süresi ve açık alan testi marjin zamanları ölçüldü. Sıçanlara uygulanan çeşitli simvastatin ve L-NAME dozlarının, yükseltilmiş artı labirent ve açık alan testine etkisi, iki yönlü varyans analizi kullanılarak değerlendirildi.Bulgular: Yükseltilmiş artı labirent testinde sadece simvastatin 40 mg/kg grubunun çözücü grubuna göre kapalı kol kalma süresinin anlamlı olarak arttırdığını gösterdi (p<0.05). Ayrıca açık alan testinde simvastatin 20 ve 40 mg/kg grubu çözücü grubuna göre marjin süresini anlamlı olarak arttırdı (p<0.05). 10 ve 50 mg/kg L-NAME dozları simvastatinin yarattığı etkiyi ortadan kaldırdı. Bulgularda gözlenen kapalı kolda kalma zamanının ve marjin süresinin artışı anksiyojenik benzeri davranış olarak değerlendirilmiştir.Sonuç: Bulgular simvastatin uygulaması ile oluşan anksiyojenik-benzeri davranışın L-NAME etkisiyle engellendiğini, dolayısıyla simvastatin uygulamasıyla oluşan anksiyojenik-benzeri davranışın nitrik oksit mekanizmasıyla düzenlendiğini göstermektedir.
MESANE TÜMÖRLÜ HASTALARIN KANLARINDA EPİGENETİK BİYOBELİRTEÇLER OLARAK PROTOKADERİN GEN AİLESİ ÜYELERİ PCDH8, PCDH10 VE PCDH17’NİN ARAŞTIRILMASI
Authors: YEĞİN Zeynep , ÖZEN Filiz , KOÇ Haydar , YILDIRIM Asıf , BÜYÜKALPELLİ Recep
Published: August 2020

Amaç: Çalışmanın amacı mesane tümörlü hastalarda ve sağlıklı kontrollerde protokaderin gen ailesine ait olan protokaderin 8 (PCDH8), protokaderin 10 (PCDH10) ve protokaderin 17 (PCDH17) genlerinin periferal kan DNA metilasyon profillerini analiz ederek bu profillerin tümör-spesifik olası etkilerini değerlendirmektir. Araştırılan üç genin metilasyon profiliyle spesifik demografik ve/veya klinikopatolojik veriler arasındaki olası ilişkinin araştırılması da çalışmanın ikinci hedefidir.Gereç ve Yöntemler: Mesane karsinomalı (n=80; düşük dereceli: 40, yüksek dereceli: 40) ve sağlıklı kontrollerin (n=40) periferal kan örneklerinden ekstrakte edilen genomik DNA promotor bölgelerinin hipermetilasyon analizi için bisülfit modifikasyon ve metilasyon-spesifik PCR işlemine maruz bırakılmıştır.Bulgular: PCDH8 metilasyon profilinin yaşla birlikte artış gösterdiği gözlenmiştir. Neredeyse kontrollerin tamamında da bu genler bakımından kısmi metilasyon profilleri belirlendiği için hasta örneklerindeki PCDH10 ve PCDH17 metilasyon paternleri bir farklılık oluşturmamakla beraber PCDH8 daha farklı bir kan epigenetik profili sergilemiştir.Sonuç: PCDH8 geninin kandaki metilasyon modelinin yaşlanma süreciyle ilişkisi çalışmamızda gösterilmiştir. Mesane kanserindeki etkisi açısından daha kesin bir sonuca varabilmek için PCDH8’in kandaki metilasyon durumunun daha yüksek sayılı kohortta ve MethyLight gibi daha duyarlı metotlarla araştırılmasını tavsiye etmekteyiz.
EL NUEVO CICLO DE REFORMAS EDUCACIONALES EN BRASIL: CONCEPCIONES, AGENTES Y PROCESOS
Authors: Donizeti Girotto Eduardo
Published: August 2020

Estamos ante un nuevo ciclo de reformas educativas en Brasil, concebido a partir de una lógica de control técnico, burocrático y gerencial del trabajo docente, que retoma procesos puestos en práctica en las décadas de 1980 y 1990 en diversas partes del mundo. Con el fin de comprender los agentes, intereses y estrategias presentes en este nuevo ciclo, analizamos, documentos publicados por organismos internacionales e institutos financiados por grupos empresariales con actuación en Brasil y en el mundo que tienen lugar de destaque en la elaboración de las actuales políticas educativas. En el análisis realizado, se verifica que el principal objetivo expresado en los documentos es la contención de las inversiones directas en educación pública. Para ello, se proponen cambios, principalmente, en la forma de contratación y organización de las carreras docentes en el país, consideradas responsables de la crisis presupuestaria brasileña. Los análisis demuestran la importancia de comprender quiénes son los principales agentes del nuevo ciclo de reformas educativas en el país, así como los intereses que expresan. Se trata de una acción fundamental en la lucha por la construcción de una escuela pública equitativa y democrática en Brasil que pasa necesariamente por la ampliación de las inversiones con el fin de garantizar las condiciones fundamentales para la acción educativa.
LAS ENCRUCIJADAS DE LO COMÚN. SISTEMATIZACIÓN DE UNA EXPERIENCIA DE ALFABETIZACIÓN DE ADULTO Y ADULTO MAYOR DESARROLLADA EN LA POBLACION EL CASTILLO
Authors: Durán Pereira Andrés , Abarca Fariel , Hidalgo Rodolfo , Vallejo Eugenia , Vera María Paz
Published: August 2020

El presente artículo sistematiza algunos elementos de la experiencia de alfabetización de adultos y adultos mayores, desarrollada durante el año 2017, en la población El Castillo, comuna de La Pintana. En particular, el texto se detiene sobre seis aspectos relevantes: posiciones biográficas de los habitantes, ansiedades y temores de pobladores, conformación del grupo de trabajo, aprendizajes subterráneos, dificultades del proceso, y desafíos a considerar para futuras experiencias de praxis comunitaria.
LAS CONTRIBUCIONES DEL CONCEPTO DE ALFABETIZACIÓN DE PAULO FREIRE PARA LOS ESTUDIOS SOBRE LA EDUCACIÓN EN DERECHOS HUMANOS.
Authors: Oliveira Cristiane , Braga Fabiana Marini , Garbim Avelino Celimara Inês
Published: August 2020

El trabajo tiene como objetivo presentar una reflexión sobre el concepto de "alfabetización" de Paulo Freire y sus contribuciones a los estudios de la Educación en Derechos Humanos. Este trabajo se puede justificar a partir de la necesidad de permitir reflexiones sobre este tipo de educación, cuyo objetivo es crear estrategias para la igualdad social y con este fin se hará uso de las contribuciones de Freire para el debate. De esta forma, será presentado un estudio bibliográfico de las obras “Educação como Prática da Liberdade” (1983), “Pedagogia do Oprimido” (2005), “Alfabetização: leitura do mundo, leitura da palabra” (2013) y “A importancia do ato de ler” (2008), haciendo una demostración de las principales apariciones del concepto de "alfabetización" y cuáles son sus ideas centrales, por medio del Análisis del Contenido. Por lo tanto, fueron agrupadas en cinco categorías semánticas de este concepto en las obras en estudio, demostrando cómo la alfabetización propuesta por Freire puede contribuir a los debates sobre la Educación en Derechos Humanos.
LAS EVALUACIONES ESTANDARIZADAS COMO CONDICIONANTES DE LA ACCIÓN DIDÁCTICA
Authors: Ferrando Miriam Andrea
Published: August 2020

El presente artículo indaga sobre las interpretaciones que docentes de primer año básico realizan al analizar una secuencia didáctica, con el objetivo de comprender la construcción del conocimiento didáctico de profesores de enseñanza básica en alfabetización inicial. El estudio formó parte de una investigación cualitativa realizada en Santiago de Chile en tres escuelas subvencionadas de la Región Metropolitana. El material analizado corresponde a entrevistas individuales, sesiones de trabajo de análisis de la secuencia didáctica y reflexión de lo realizado, observaciones de clases y acompañamiento en sala. Los hallazgos indican que las evaluaciones estandarizadas actúan como condicionantes de la acción didáctica. Los docentes consideran que estas mediciones ocupan un lugar privilegiado respecto de las prácticas en alfabetización inicial.
DIVERSIFICANDO LA EVALUACIÓN EN LA PRÁCTICA PEDAGÓGICA: ORIENTACIONES DESDE LA NORMATIVA LEGAL Y UN IMPULSO HACIA LA INCLUSIÓN PARA LA JUSTICIA SOCIAL
Authors: Garate Vergara Francisco
Published: August 2020

El presente escrito tiene su concepción en el desarrollo de una escuela inclusiva para la justicia social, en donde la evaluación es un elemento pendiente y cuya comprensión ayudará para el logro de una educación de calidad y transformadora. Se busca mostrar la visión y características pedagógicas con la implementación de las nuevas políticas educativas en torno a la diversidad e inclusión, con respecto al diseño universal de los aprendizajes y la vinculación con la evaluación para el aprendizaje y, desde este elemento, un impulso para la justicia social. Se cuestiona cómo se entregan elementos con vacíos pedagógicos en base a la enseñanza – aprendizaje y evaluación de los aprendizajes, sin considerar la diversidad presente en las aulas y el aprendizaje de toda la comunidad educativa. Se generan recomendaciones de cambio cultural y participativo y en la diversificación de las técnicas e instrumentos, en torno a las competencias curriculares.  Se indica una evaluación completa y compleja en base a las habilidades, contenidos y actitudes desarrolladas y evaluadas con diversas técnicas e instrumentos, que aportarán para el logro de una evaluación diversificada para la inclusión de calidad educativa en el sistema educativo chileno, promoviendo la transformación de la escuela en pos de la justicia social.
PROBLEMAS MATEMÁTICOS: APLICACIÓN DE ALGORITMOS EN DIVERSOS CONTEXTOS, MÁS QUE UNA SITUACIÓN DESAFIANTE PARA LOS ESTUDIANTES
Authors: Torres Díaz Romi Alejandra , Sanchez Bustos Mario Arturo
Published: August 2020

Esta investigación busca caracterizar la visión que tienen los profesores que realizan clases de matemática en educación primaria y profesores en formación de la misma área, sobre los métodos y elementos necesarios para resolver problemas matemáticos en los distintos ejes del currículum nacional. Para el estudio se realizaron entrevistas a profesores y estudiantes de pedagogía con mención en matemática en una provincia de la Región del Maule, Chile; además, se complementó con las propuestas existentes en textos escolares vigentes a nivel nacional. Los datos se clasificaron de acuerdo a la solución de estos y el nivel de relación con la aplicación directa de algoritmos. Los resultados evidencian que, en su mayoría, sus planteamientos y soluciones demandan poco razonamiento lógico matemático, y más bien se centran en el conocimiento de definiciones formales y operaciones previamente establecidas; perspectiva opuesta a lo planteado por diversos exponentes de la didáctica matemática contemporánea, desde la que nos posicionamos, pues, creemos que un buen problema debería involucrar la búsqueda de una estrategia desconocida y creativa para su resolución.
Palabras claves: problemas matemáticos, resolución de problemas, algoritmos, didáctica matemática, estrategias.
EMOCIONES DE ESTUDIANTES DE TERCER AÑO BÁSICO EN EL CONTEXTO DE EVALUACIONES ESCRITAS EN EDUCACIÓN MATEMÁTICA
Authors: Vejar Barra Melissa Betzabé , Ávila Contreras Jorge Iván
Published: August 2020

El presente artículo reporta resultados de una investigación acerca de las emociones que vivencian estudiantes de tercer año de educación primaria, en una evaluación escrita de Educación Matemática. Se trabaja con base en la perspectiva del pensamiento complejo de Edgar Morín, la noción de complejidad vivencial y la relación emoción/color de acuerdo a la rosa cromática de Plutchik. El enfoque metodológico es cualitativo con diseño de estudio de casos. Los hallazgos reportan asociación de emociones del estudiantado con elementos personales o situaciones que vivencian principalmente con sus padres más que con las matemáticas, y la asociación de sus emociones con el color se vincula más con aspectos de su experiencia cotidiana que con los colores indicados por la rosa cromática de Plutchik.
Palabras clave: Emociones, evaluación en Educación Matemática, pensamiento complejo, complejidad vivencial, relación color emoción, educación primaria.
Determining Customer Relationship Management Strategy With Customer Personality Analysis Using Ontology Model Approach
Authors: Ramadhanti Alya Rysda , Bastikarana Rafa Syafiq , Alamsyah Andry , Widiyanesti Sri
Published: August 2020

Indonesia is a market with attractive e-commerce growth in the past four years. The tight competition made the company try to find ways to maintain customer loyalty, including making improvements to the Customer Relationship Management (CRM) strategy. The way to establish a good CRM strategy is driven by a good approach from the company to customers. Through the process of understanding customer personality, major companies able to understand their customer behaviour, therefore, companies driven by their marketers can perform product marketing activities that are tailored to the tendency of the customer's personality. This research was conducted to determine the personality of the customer by utilizing data obtained from online reviews of several products using the ontology model approach. Personality is measured based on words and phrases given by customers through their online reviews with the help of the Big Five Personality theory in the classification process. The results of this study indicate that the measurement of personality using an ontology model reconstructed with the n-gram algorithm shows that customers on several products have different personalities. These personalities can be used as a foundation in determining and establishing CRM strategies in order to gain higher customer engagement.
Keywords—Customer Relationship Management; Online Review; Ontology Model; Personality Measurement
Factors Causing the Poor Management of Village-Owned Enterprises (BUMDes) in Garut Regency
Authors: Kania A.Ikeu
Published: August 2020

The management of BUMDes in Garut Regency is still not in accordance with the mandate of the laws and regulations that its establishment is intended to create and to improve the prosperity of rural community life better through mobilization and management of village potential. This study aims to discover the factors that cause the low management of BUMDes in Garut Regency. Using a quantitative approach, the survey was conducted toward BUMDes management who are in the categories of semi-active and not yet active. A total of 161 respondents were selected by a simple random sampling method which was further analyzed using exploratory factor analysis with 32 indicators. The results showed that of the 32 indicators tested, 8 new factors are formed as factors that lead to poor management of BUMDes in Garut Regency. These factors include management, human resources, environmental conditions, personality, organization, policy, professionalism and communication.

Keywords: Management, Exploratory Factor Analysis, BUMDes, Rural Community
Measuring Smart Building Readiness Index: A Case Study of Bandung City
Authors: . Indrawati , Nurillaily Angdini , Amani Husni , Pillai S. K. B.
Published: August 2020

Government and private players started focusing on developing cities in to smart cities due to increased level of urbanization in most of the countries around the world, including in Indonesia, by focusing on developing new smart buildings and upgrading old ones. Present paper tried to find out the Smart Building Readiness Index (SBRI) of Bandung City for knowing the level of awareness among the general public based on an exploratory research, the result of which enables the authorities to take strategic initiatives for improving the smart buildings and then to smart city status. Required data was collected by conducting in-depth interviews with 30 respondents and the result of the qualitative data revealed that Bandung’s SBRI comes to only 64.39, which is not a good indicator but within the limits of fairness and needs lot of improvement in future. The result also can be considered as an indicator that annual energy consumption in Bandung city is still at a high level and needs to focus on improving the quality of buildings in and around Bandung city for the purpose of overall reduction in energy consumption and improvement in quality of environment as well as quality of life. Respondents are also not fully aware of the smart building concept. Much needs to be done for making the public aware of the concept of smart building and its usefulness along with strategically developing smart buildings so that in future Bandung city transforms into a smart city with smart buildings.

Keywords— Smart City; Smart Building Readiness Index; Bandung.
Factors Affecting Decisions To Choose Application Based Transportation
Authors: Husda Nur Elfi , . Nuramaliafitrah
Published: August 2020

The existence of service application for ojek and call taxi is a solution for people who have difficulty using public transport due to its accessibility and point to point pick up service. This study aims to determine the factors that influence customer decisions in using application-based “Motorbike Taxi” like Go-Jek. This research was conducted on the Putera Batam University’s students that have used Go-Jek application, with a sample size of 100 students as its respondents. The sampling technique used is incidental sampling method and is estimated to represent the population. Data analysis method used in this research is descriptively quantitative analysis of the factors that influence students in using the services of Go-Jek. The results showed that service quality factors that influence students’ decisions to choose transportation services based on “Motorbike Taxi” service orders consist of 6 factors: service, completeness of driving, security, trust, responsiveness and reliability, where the most dominant factor is service factor.
Keywords: Application-based transportation, service quality, customer decisions
Consumer Preference Influence Towards Revenue Optimization for Local Brand Accessories in Bandung
Authors: Rahadi Raden Aswin , Shafira Shanaya Ratu
Published: August 2020

Planning a careful market and good product strategy in launching new products is very important to help new company succeed in the market with knowing the consumer preference and cashflow projection. This research raises the issue of the importance of consumer preference to get optimal revenue on launching new product. This research was conducted at Soigne, a local brand accessory in Bandung. The purpose of this study is to determine how the company conducts feasibility study through consumer preferences for knowing the suitable price and products to launch in 2019. This study also analyses the sensitivity analysis to delimit the changes of financial conditions. According to the result of the research, there are recommendations that can be applied in Soigne to launch a suitable product to gain optimal revenue based on consumer preference. The best combination product to launch in Soigne is accessories product between earrings, bracelet, and necklace with neutral color, simple design, and price range between IDR 100,000.00 to IDR 250,000.00. Customer service, packaging design, materials and durability is other factor that important to provide by the company. For the optimal revenue, Soigne recommended to launch earrings with price IDR 149,000.00, bracelet with price IDR 169,000.00, and necklace with price IDR 189,000.00 in the next one year and increase 10% for the price in the next two and three years which are the best financial scenario of researcher projection.
Keywords— Cashflow Projection; Consumer Preference; Feasibility Study; Launching New Product; and Sensitivity Analysis
NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products
Authors: kim Hyunwoo , Wang Mingxun , Leber Christopher , Nothias Louis-Felix , Reher Raphael , Kang Kyo Bin , van der Hooft Justin J. J. , Dorrestein Pieter , Gerwick William , Cottrell Garrison
Published: August 2020

Computational approaches such as genome and metabolome mining are becoming essential to natural products (NP) research. Consequently, demands for automated NP classification system for massive data are increasing. The semantic ontology of NPs classifies molecules based on the taxonomy of the producing organism, the nature of the biosynthetic pathway, their biological properties, as well as the presence of chemical substructures. Thus, a holistic and automatic NP classification framework could have considerable value to comprehensively navigate the relatedness of NPs. Here, we introduce NPClassifier, the first deep-learning tool for the automated structural classification of NPs. We expect that NPClassifier will accelerate NP discovery by facilitating and enabling large-scale genome and metabolome mining efforts and linking of NP structures to their underlying bioactivity.
Rigorous Quantification of the statistical significance of COVID-19 lockdown effect on air quality: The case from ground-based measurements in Ontario, Canada
Authors: Al-Abadleh Hind A. , Lysy Martin , Neil Lucas , Patel Priyesh , Mohammed Wisam , Khalaf Yara
Published: August 2020

Preliminary analysis of satellite measurements from around the world showed drops in nitrogen dioxide (NO2) with lockdowns due to the COVID-19 pandemic. A number of studies have found these drops to be correlated with local decreases in transportation and/or industry. None of these studies, however, has rigorously quantified the statistical significance of these drops relative to natural meteorological variability and other factors that influence pollutant levels during similar time periods in previous years. Here, we develop a novel statistical testing framework that accounts for seasonal variability, transboundary influences, and new factors such as COVID-19 restrictions in explaining trends in several pollutant levels at 16 ground-based measurement sites in Southern Ontario, Canada. We find statistically significant and temporary drops in NO2 (11 out 16 sites) and CO (all 4 sites) in April-June 2020, with pollutant levels 20% lower than in the previous three years. Much fewer sites (2-3 out of 16) experienced statistically significant drops in O3 and PM2.5. The statistical testing framework developed here is the first of its kind applied to air quality data, and highlights the need for rigorous assessment of statistical significance, should analyses of pollutant level changes post COVID-19 lockdowns be used to inform policy decisions in Ontario, Canada. See Methods section in the manuscript.
Comparison of Computational Chemistry Methods for the Discovery of Quinone-Based Electroactive Compounds for Energy Storage
Authors: Zhang Qi , Khetan Abhishek , Er Süleyman
Published: August 2020

High-throughput computational screening (HTCS) is an approach that can enable rational and time-efficient discovery of electroactive compounds. The effectiveness of HTCS is dependent on the accuracy and speed at which the performance descriptors can be estimated for possibly millions of candidate compounds. Here, a systematic evaluation of computational methods, including force field (FF), semi-empirical quantum mechanics (SEQM), density functional based tight binding (DFTB), and density functional theory (DFT), is performed on the basis of their accuracy in predicting the redox potentials of redox-active organic compounds. Geometry optimizations at lower level theories followed by single point energy (SPE) DFT calculations including an implicit solvation model are found to offer equipollent accuracy as the higher level DFT methods, albeit at significantly lower computational costs. Effects of implicit solvation on molecular geometries and SPEs, and their overall effects on the prediction accuracy of redox potentials are analyzed in view of computational cost versus prediction accuracy, which outlines the best choice of methods corresponding to a desired level of accuracy. The modular computational approach presented here is expected to be applicable for accelerating virtual studies on functional quinones and the respective discovery of candidate compounds for energy storage.
TIPS-Naphthalene for Efficient Visible-to-UV Photon Upconversion under Sunlight and Room Light
Authors: Harada Naoyuki , Sasaki Yoichi , Hosoyamada Masanori , Kimizuka Nobuo , Yanai Nobuhiro
Published: August 2020

Until now, the efficiency of triplet-triplet annihilation-based photon upconversion (TTA-UC) from visible to ultraviolet (UV) light has been limited to ca. 10% due to the absence of high-performance acceptors (emitters). Here, we present the first example of visible-to-UV TTA-UC internal efficiency ηUC beyond 20% by developing a novel UV emitter, 1,4-bis((triisopropylsilyl)ethynyl)naphthalene (TIPS-Nph), and sensitizing its triplet by a donor Ir(C6)2(acac) with strong visible absorption and weak UV absorption. Under optimized conditions, 97% of the excitation light is absorbed, the threshold excitation intensity (Ith = 1.1 mW cm−2) is lower than the solar irradiance (1.4 mW cm−2 for 445 ± 5 nm), and significantly, the highest external UC efficiency ηUC,ext of 17.4% for vis-to-UV TTA-UC is achieved. Upconverted UV emission can also be obtained with weak light sources such as an AM 1.5 solar simulator and room LEDs, paving the way for a variety of solar and indoor applications.
Engineering of Saccharomyces pastorianus Old Yellow Enzyme 1 for the Synthesis of Pharmacologically Active (S)-Profen Derivatives
Authors: Liu Guigao , Li Shang , Shi Qinghua , Li Hengyu , Guo Jiyang , Ouyang Jingping , Jia Xian , Zhang Lihan , You Song , Qin Bin
Published: August 2020

2-Arylpropionic acid derivatives, such as ibuprofen, constitute an important group of non-steroidal anti-inflammatory drugs (NSAIDs). Biocatalytic asymmetric reduction of 2-arylacrylic acid derivatives by ene reductases (EREDs) is a valuable approach for synthesis of these derivatives. However, previous bioreduction of 2-arylacrylic acid derivatives by either ERED wild-types or variants resulted solely in nonpharmacological (R)-enantiomers as the products. Here, we present the engineering of Saccharomyces pastorianus old yellow enzyme 1 (OYE1) into (S)-stereoselective enzymes, which afford pharmacologically active (S)-profen derivatives. By structural comparison of substrate recognition in related EREDs and analysis of non-covalent contacts in the pro-S model of OYE1, the key residues of OYE1 that switch its stereoselectivity to an (S)-stereopreference were identified. Systematic site-directed mutagenesis screening at these positions successfully provided the (S)-stereoselective OYE1 variants, which catalyzed stereoselective bioreduction of various profen precursors to afford pharmacologically active (S)-derivatives including (S)-ibuprofen and (S)-naproxen methyl esters with up to >99% ee values. Moreover, the key residues and mutation strategy obtained from OYE1 could be further transferred to OYE 2.6 (from Pichia stipitis) and KnOYE1 (from Kazachstania naganishii) to create the (S)-stereoselective EREDs. Our results may provide a generalizable strategy for stereocontrol of OYEs and set the basis for biocatalytic production of (S)-profens.
Using Domain-specific Fingerprints Generated Through Neural Networks to Enhance Ligand-based Virtual Screening.
Authors: Menke Janosch , Koch Oliver
Published: August 2020

Molecular fingerprints are essential for different cheminformatics approaches like similarity-based virtual screening. In this work, the concept of neural (network) fingerprints in the context of similarity search is introduced in which the activation of the last hidden layer of a trained neural network represents the molecular fingerprint. The neural fingerprint performance of five different neural network architectures was analyzed and compared to the well-established Extended Connectivity Fingerprint (ECFP) and an autoencoder-based fingerprint. This is done using a published compound dataset with known bioactivity on 160 different kinase targets. We expect neural networks to combine information about the molecular space of

already known bioactive compounds together with the information on the molecular structure of the query and by doing so enrich the fingerprint. The results show that indeed neural fingerprints can greatly improve the performance of similarity searches. Most importantly, it could be shown that the neural fingerprint performs well even for kinase targets that were not included in the training. Surprisingly, while Graph Neural Networks (GNNs) are thought to offer an advantageous alternative, the best performing neural fingerprints were based on traditional fully connected layers using the ECFP4 as input. The best performing kinase-specific neural fingerprint will be provided for public use.
Structural Effects of Cation Binding to DPPC Monolayers
Authors: Javanainen Matti , Hua Wei , Tichacek Ondrej , Delcroix Pauline , Cwiklik Lukasz , Allen Heather
Published: August 2020

Ions at the two sides of the plasma membrane maintain the transmembrane potential, participate in signaling, and affect the properties of the membrane itself. The extracellular leaflet is particularly enriched in phosphatidylcholine lipids an under the influence of Na+, Ca2+, and Cl− ions. In this work, we combined molecular dynamics simulations performed using state-of-the-art models with vibrational sum frequency generation (VSFG) spectroscopy to study the effects of these key ions on the structure of dipalmitoylphosphatidylcholine. We used lipid monolayers as a proxy for membranes, as this approach enabled a direct comparison between simulation and experiment. We find that the effects of Na+ are minor. Ca2+, on the other hand, strongly affects the lipid head group conformations and induces a tighter packing of lipids, thus promoting the liquid condensed phase. It does so by binding to both the phosphate and carbonyl oxygens via direct and water-mediated binding modes, the ratios of which depend on the monolayer packing. Clustering analysis performed on simulation data revealed that changes in area per lipid or CaCl2 concentration both affect the head group conformations, yet their effects are anti-correlated. Cations at the monolayer surface also attract Cl−, which at large CaCl2 concentrations penetrates deep to the monolayer. This phenomenon coincides with a radical change in the VSFG spectra of the phosphate group, thus indicating the emergence of a new binding mode.
A Microscopic Description of SARS-CoV-2 Main Protease Inhibition with Michael Acceptors. Strategies for Improving Inhibitors Design
Authors: Ramos-Guzmán Carlos A. , Ruiz-Pernía J. Javier , Tuñón Iñaki
Published: August 2020

The irreversible inhibition of the main protease of SARS-CoV-2 by a Michael acceptor compound known as N3 has been investigated using multiscale simulation methods. The noncovalent enzyme-inhibitor complex was simulated using classical Molecular Dynamics techniques and the pose of the inhibitor in the active site was compared to that of the natural substrate, a peptide containing the Gln-Ser scissile bond. The formation of the covalent enzyme-inhibitor complex was then simulated using hybrid QM/MM free energy methods. After binding, the reaction mechanism was found to be composed of two steps: i) the activation of the catalytic dyad (Cys145 and His41) to form an ion pair and ii) a Michael addition where the attack of the Sg atom of Cys145 to the Cb atom of the inhibitor precedes the water-mediated proton transfer from His41 to the Ca atom. The microscopic description of protease inhibition by N3 obtained from our simulations is strongly supported by the excellent agreement between the estimated activation free energy and the value derived from kinetic experiments. Comparison with the acylation reaction of a peptide substrate suggest that that N3-based inhibitors could be improving adding chemical modifications that could facilitate the formation of the catalytic dyad ion pair.
Comportamiento y desigualdades sociales en indicadores priorizados del Objetivo de Desarrollo Sostenible 3 en Bolivia
Authors: Enríquez Nava Max Francisco , Esquivel Velásquez Adhemar David , Patón Sanjines Mabel , Pooley Ayarza Bertha Cecilia , Alarcón René , Hernández Muñoz Rosalinda , Sanhueza Antonio
Published: August 2020

Objetivo.Describir el comportamiento y las desigualdades sociales en indicadores priorizados del Objetivo de Desarrollo Sostenible 3 (ODS-3) entre subpoblaciones y departamentos de Bolivia.

Métodos.Se realizó un análisis del comportamiento de indicadores seleccionados del ODS-3 en el tiempo. Además, se llevó a cabo un estudio de desigualdades sociales en estos indicadores para estratificadores de equidad seleccionados. Se obtuvieron las medidas simples (brecha absoluta y brecha relativa) y las medidas complejas (índice de desigualdad de la pendiente e índice de concentración) para explorar la magnitud de las desigualdades sociales.

Resultados.Los indicadores del ODS-3 que han tenido un aumento importante a nivel nacional y departamental son la prevalencia de cuatro controles prenatales y la prevalencia de parto atendido por personal de salud calificado. Las desigualdades sociales en estos indicadores han disminuido de manera significativa en el tiempo. La prevalencia de embarazo en adolescentes y sus desigualdades sociales se han mantenido sin mayores cambios, aunque con desigualdades bajas. La prevalencia de uso de métodos anticonceptivos modernos ha disminuido en forma leve, aunque la desigualdad social ha tenido una disminución más rápida. La razón de muerte materna ha disminuido a nivel nacional y en la mayoría de los departamentos, pero aún se requiere atacar la desigualdad social en este indicador.

Conclusiones.Los promedios nacionales ocultan diferencias entre las subpoblaciones y los departamentos de Bolivia. Los hallazgos muestran que se ha mejorado en el comportamiento y desigualdad social de algunos indicadores del ODS-3, pero que en otros se deben fortalecer las intervenciones por diferentes actores para disminuir las desigualdades sociales en salud.
Educational strategies for human resources in home health care: 8 years’ experience from Brazil
Authors: Savassi Leonardo Cancado Monteiro , Dias Mariana Borges , Boing Antonio Fernando , Verdi Marta , Lemos Alysson Feliciano
Published: August 2020

Objective. To analyze characteristics, enrollments and completion rates of healthcare professionals enrolled in Self-Instructional Online Courses of the Home Health Care Multicentre Qualification Program, developed by the Ministry of Health and the Universidade Aberta do SUS (UNASUS), and its relationship with Home Health Care Teams implementation.

Methods. Data were extracted from the Self-Instructional Online Courses’ UNASUS enrollment platform database (2012-2018), cross-referenced with the Health Facilities’ National Database and compared to Home Care General Coordination team’s database. Main outcomes were completion rates and number of courses enrollments, analyzed by sex, age, region, location, profession, workplace, health teams and course type.

Results. Men applied to courses slightly more than women and completion rates were higher (37.1 vs 30.5, p < 0.001); there was a small decline in completion rates by age groups (from 32.8% in 18-29 yr to 31.1% in 46-50 yr age group, p < 0.001) and a rise in course enrollment number, probably related to progressively “digital native” generations. Self-Instructional Online Courses were attended in all Brazilian states and reached all municipality sizes, with completion rates rising from 29.9% in the North to 37.3 in the South; 30-hour courses were completed by almost twice as many professionals as 45-hour and 60-hour courses, suggesting that modularity may improve completion rates. State distribution and national coverage suggest adequate range and coincidence between enrollment and Home Health Care Teams distribution.

Conclusions. Regional aspects influence professional interaction with courses; the feminization of health professions and women’s lower completion rates suggest the need for a deeper gender perspective in health facilities and training services. Self- Instructional Online Courses for Home Health Care were an important outreach strategy, with professional’s doubts answered more contextually.
Fostering sustainable tribal economies in a time of climate change
Authors: Bargh Ema Maria , Douglas SL , Te One Annie
Published: August 2020

In this article, we explore how Maori tribal organisations are responding to calls by other Indigenous peoples to become more sustainable in a time of climate change. From a close examination of tribal Environmental Management Plans, we move to a specific case study in the Bay of Plenty area, Ngati Kea/Ngati Tuara. Ultimately, we suggest that many tribal organisations are seeking to respond to climate change and transition to becoming producers of their own food and energy needs, and are often articulating these responses in relation to specific local resources and contexts. © 2014 New Zealand Geographical Society.
Investor Attention, Market Dynamics, and Momentum in the Korean Stock Market
Authors: Eom Cheoljun , Chang Uk , Kang Byung Jin , Lee Woo Baik , Park Jong Won
Published: August 2020

This study examines the effects of investor attention on momentum in the Korean stock market. The results reveal significant negative momentum profits in stock groups with high investor attention (high turnover stocks), but insignificant results in those with low investor attention (low turnover stocks). Within high turnover stock groups, the winner portfolio has a declining price trend and insignificant performance, while the loser portfolio realizes significant positive performance through a substantial price increase in the future period. The momentum effect is highly dependent on the reversed performance of the loser portfolio. Second, the performance of the large overreaction stock group shows a more significant negative momentum effect compared to the low overreaction stock group, that is, the degree of overreaction significantly affects the momentum effect. Third, negative momentum profits are consistently observed regardless of the market dynamics. Specifically, more substantial and significant negative performance occurs in the transition market, where the market situation reverses between the past and future periods. Fourth, negative momentum profits are consistently identified even after controlling for the impact of common factors and volatility and liquidity into turnover. Our findings are qualitatively different from the characteristics of the traditional momentum effects generally reported in Western countries.
Legitimidade do réu e requerimento da tutela antecipada
Authors: Carvalho Odilair
Published: August 2020

O presente estudo tem como objetivo a analise da hipótese de o réupostular a antecipação de tutela. Para tal consecução de tal mister, primeiramente procederemos a um estudo do conceito de Tutela Jurisdicional, passando pela análise da Jurisdição como função/dever que decorre da Soberania Estatal, para, para concluir que a Tutela Jurisdicional pode ser obtida tanto pelo autor, em caso de procedência da demanda, como pelo réu, em caso de improcedência da pretensão autoral. Partido dessa premissa chegar-se-á a uma abordagem da antecipação de tutela, partindo de sua conceituação à análise dos requisitos exigidos pelo ordenamento processual para a sua concessão, para, ao final, concluir que o réu também detém legitimidade, mesmo não deduzindo pedido contraposto, para pleitear a antecipação dos efeitos práticos de uma sentença de improcedência.
atuação religiosa na organização do estado brasileiro
Authors: Silva Betânia Teodora Andrade da
Published: August 2020

O presente artigo visa analisar a evolução da configuração do Brasil sob a luz da religião que durante séculos teve consigo o domínio das primeiras formas de governo instituidas no páis. Será observada a implantação da religião cristã no Brasil colônia e noções de governo subordinado à religião. Em seguida, será vista a desconstrução do Estado-Igreja através das Constituições, com uma síntese sobre as raízes da laicidade.
The Effect of Acute High Intensity Interval Training on Alertness and Executive Function in Basketball Player
Authors: Limyati Yenni , Budiman Iwan , Harja Ryan Setyadi , Ibrahim Iqbal
Published: August 2020

Kelelahan dan kurang tidur pada pemain basket dapat menyebabkan penurunan kewaspadaan dan fungsi eksekutif sehingga mengganggu kinerja olahraga. Tujuan penelitian ini untuk mengetahui pengaruh High Intensity Interval Training (HIIT) akut terhadap peningkatan kewaspadaan dan fungsi eksekutif pada pemain basket. Metode penelitian ini adalah eksperimental semu yang bersifat analitik dengan desain pre test-post test. Subjek penelitian terdiri dari 30 orang laki- laki pemain basket yang diberi perlakuan HIIT dengan melakukan 12 gerakan yang masing – masing gerakannya berdurasi 30 detik dan diselingi dengan istirahat antara gerakan satu dengan gerakan lainnya selama 10 detik sesuai dengan aplikasi 7-minute workout dalam satu kali pertemuan (akut). Data yang diukur adalah waktu (detik) yang dibutuhkan dalam menyelesaikan Johnson-Pascal Test dan Trail Making Test Part ‘B’ sebelum dan sesudah melakukan HIIT. Analisis data menggunakan uji “t” berpasangan (? = 0,05). Hasil penelitian rerata Johnson Pascal Test post test 108,17 detik (SD ± 14,842) lebih cepat daripada rerata pre test 129,43 detik (SD  ± 19,977) (p<0,05). Hasil rerata Trail Making Test Part ‘B’ post test 29,64 detik (SD ± 11,99) lebih cepat daripada rerata pre test  44,91 detik  (SD ± 16,33) (p<0,05).  Disimpulkan bahwa HIIT akut meningkatkan kewaspadaan dan fungsi eksekutif pada pemain basket.

 

Kata kunci: HIIT; kewaspadaan; fungsi eksekutif;  kurang tidur; pemain basket
Development of directions for improvement of information support of customs control after goods release
Authors: Agapova Anna
Published: August 2020

In the scientific article, based on the analysis of information support for customs control after the release of goods, directions for improving such control were developed. In particular, it is proposed to develop at the level of the Federal Customs Service of Russia an information system integrated with such systems of other countries, which will store documents received from authorized customs authorities of foreign countries
ECONOMIC SECURITY OF EDUCATIONAL ORGANIZATIONS AS AN IMPORTANT COMPONENT OF THE ECONOMIC SECURITY OF THE STATE
Authors: Bank Sergey
Published: August 2020

Economic security is an important integral component for the entire educational complex, for individual educational structures, for each person involved in the educational process. A significant component of the process of providing economic security for a set of educational institutions in the form of an educational complex is the provision of the said security at the level of each individual educational structure, which depends on a huge number of factors of completely different origins, the duration of their influence, and the scope of their action.
MODELS of PAYBACK of SUBSIDIES in AGRARIAN BUSINESS
Authors: Samygin Denis
Published: August 2020

The problem of payback of subsidies in agricultural industry due to obligatory payments in the budgetary system of the country rises. It is shown that the minority of this problem for the state is caused by the social and economic importance of the industry for society and inaccuracy of opinion on low budgetary efficiency of allocations in agricultural production. The technique of assessment of efficiency of use of funds of state support from a position of the state financial system is proved. On the basis of the analysis it is revealed that at creating favorable conditions of development of producers not only prerequisites of ensuring food security and preservation of rural territories, but recoverability of means due to obligatory payments in the budget and off-budget funds are formed. By means of the constructed models the optimum ratio of payback of subsidies and profitability of costs of production taking into account conditions of simple and expanded reproduction of resources without loss of cost of the budgetary investments is revealed. The importance of results of a research consists in the revealing opportunities of planning of efficiency of use of the raised funds in production of agricultural products both for agrarian business, and for the state.