bluuebunny/crossref_metadata_2025 huggingface dataset:
УПОРЕДНА АНАЛИЗА ПОКАЗАТЕЉА РАДА СИСТЕМА ЈАВНОГ ПРЕВОЗА ПУТНИКА У НОВОМ САДУ И НИШУ
Authors: Живојиновић Марија , Симеуновић Милан
Published: April 2020

На основу системског бројања и анкете путника, за град Ниш из 2007 године, а за града Нови Сад из 2003, 2010. и 2017. године извр­шена је упоредна анализа показатеља рада система јавног превоза путника.
KARAKTERISTIKE ŠINSKOG SISTEMA JAVNOG GRADSKOG PREVOZA PUTNIKA
Authors: Kežić Siniša , Simeunović Milan
Published: April 2020

U radu su predočeni svi konvencio­nalni načini linijskog prevoza putnika u gradu, sa posebnom analizom lakog šinskog sistema u TelAviv-u i date su određenje preporuke za gradove u okruženju.
СТАВОВИ И ПОНАШАЊА ВОЗАЧА НА ДВОТРАЧНИМ КРУЖНИМ РАСКРСНИЦАМА У РЕПУБЛИЦИ СРПСКОЈ
Authors: Кресојевић Саша , Богдановић Вук
Published: April 2020

У оквиру рада се врши прорачун капацитета раскрснице по HCM 2016 приручнику, испитивање ставова возача о овим раскрсницама, упоређивање понашања у реалном саобраћајном току са ставовима и законском регулативом.
UTICAJ MUZIČKOG ŽANRA NA PREFERENCIJU OBLIKA ZVUČNIKA KORISNIKA
Authors: Stanković Jovana , Vladić Gojko
Published: April 2020

Predmet rada je  istraživanje povezanosti različitih muzičkih žanrova sa različitim oblicima zvučnika kao i različitim geometrijskim oblicima. Cilj rada je ispitati da li muzika utiče na odabir određenog oblika proizvoda od strane korisnika. Na osnovu dobijenih rezultata istraživanja, kreiranje koncept zvučnika za klasičnu muziku.
KOMPARATIVNA ANALIZA AKTUELNIH CSS TEHNIKA ZA RASPORED ELEMENATA NA VEB STRANICAMA
Authors: Klisara Ognjen , Milić Keresteš Neda
Published: April 2020

Rad predstavlja poređenje aktuelnih tehnika koje se koriste za raspored elemenata na stranici. Teorijski deo hronološki prati razvoj tehnika za raspored elemenata i analizira njihov uticaj na dizajn, sa fokusom na savremene CSS3 tehnike i prednosti koje one donose. Praktični deo predstavlja demonstraciju tih tehnika kroz izradu veb projekta, poštujući principe art direkcije u veb dizajnu.
POSTOJANOST TEKSTILNIH OTISAKA U PROCESU EKSPLOATACIJE
Authors: Nađalin Ivan , Kašiković Nemanja , Lilić Ana
Published: April 2020

Cilj ovog rada je ispitati postojanost i promenu otisaka štampanih tehnikama sito i digitalne štampe na tekstilu pod uticajem dejstava trljanja, peglanja i pranja u odnosu na početno stanje. Kao promenjivi parametri uzeti su tehnika štampe, boja i vrsta tekstila. Promena razlike u boji meri se nakon svakog ciklusa izlaganja trljanju, pranju i peglanju.
REKONSTRUKCIJA HRANE ZA POTREBE ARHITEKTONSKE VIZUALIZACIJE
Authors: Ćurčin Dragica
Published: April 2020

U ovom radu analiziran je problem kreiranja hrane za potrebe arhitektonske vizuelizacije. Poređenjem dve metode, rekonstrukcijom modela koriš­ćenjem automatskog programa AgiSoft Photoscan-a i modelovanje hrane u nekom od programa za 3D mode­lovanje, razmotrene su mane i prednosti ovih metoda. Prilikom kreiranja scene za potrebe arhitektonske vizuali­zacije, potrebno je da scena izgleda što realističnije, stoga se dodavanjem objekta kao što je hrana dobija takav efekat. Kako bi model bio zadovoljavajući, potrebno je obratiti pažnju na detalje kao i na samu teksturu objekta, takođe treba voditi računa o broju poligona, kako ne bi došlo do problema prilikom uklapanja modela u scenu.
INTERAKTIVNA VIZUALIZACIJA PAMETNOG STANA KORIŠĆENJEM UNREAL ENGINE-A
Authors: Bojović Bogdana
Published: April 2020

U radu je analiziran problem inter­aktivne arhitektonske vizualizacije pomoću koje je prika­zan primer pametnog stana sa određenim funkcijama. Kako pametni stanovi podrazumevaju prilagođavanje ambijenta željama korisnika, obično postoji problem kako to predočiti korisniku, a da bude efikasno, uverljivo i eko­nomično. Ono što je najznačajnija funkcija sistema kućne automatike u pametnim stanovima su programski scena­riji, te su kroz ovaj rad, koji podrazumeva tri takva scena­rija, u programu Unreal Engine, prikazane funkcije adekvatne za svaki od njih. Cilj rada jeste istražiti moguć­nosti što realističnijeg simuliranja funkcija koje ovakvi stanovi poseduju.
VIZUALIZACIJA POZORIŠNOG OSVETLJENJA NA PRIMERU INSTALACIJE VODE
Authors: Stojkečić Jelena
Published: April 2020

U ovom radu opisana je problematika korišćenja vode kao scenografskog elementa u pozorištu i prikazano je rešenje koje je dobijeno testiranjem različitih rasvetnih instrumenata, njihovog pozicioniranja u pro­storu i kvaliteta svetla, kao i materijala koji se koristi za izradu scenografskog dekora. Cilj ovog rada je dobijanje idealnog scenografskog rešenja elementa vode primenom programa za 3d modelovanje i renderovanje u pozorišnoj umetnosti.
САВРЕМЕНА АРХИТЕКТУРА СРЕМСКЕ МИТРОВИЦЕ ХХ ВЕКА
Authors: Бекавац Давид
Published: April 2020

У раду је приказана анализа и критика савремене архитектуре ХХ века у Сремској Митровици. Рад се бави преиспитивањем квалитета грађене средине и поставља питање о разлозима недовољне препознатљивости архитектуре овог града.
KINETIČKA FASADA BAZIRANA NA TROUGAONIM FASADNIM PANELIMA
Authors: Jokić Ognjen
Published: April 2020

Na fasadnom platnu koje je obrađeno u ovom radu, primenjen je konstruktivni sistem koji omogu­ćava različite varijacije u dizajnu koji mogu zadovoljiti makro i mikro uslove lokacije, različite korisničke potrebe, različite dizajnerske želje, serijsku ili induvidualnu proiz­vodnju pojedinačnog panela i aplikaciju različito materija­lizovanih opni na primarnu aluminijumsku konstrukciju.
PROJEKAT ŠUMSKOG VRTIĆA NA PODRUČJU FRUŠKE GORE
Authors: Kolarski Velizar
Published: April 2020

Projektovanje vrtića specifične meto­dologije rada u prirodnom okruženju, sa ciljem ostvari­vanja što pravilnijeg vaspitanja dece, i rešavanja pitanja nedostatka vrtića u Novom Sadu.
UPOREDNA ANALIZA PARAMETARA VEŠTAČKOG SVETLA I KAMERE NA FOTOGRAFIJI I RENDERU ENTERIJERA
Authors: Milutinović Miroslava
Published: April 2020

Istraživanje se bazira na analizi parametara veštačkog osvetljenja i kamere u renderu i u stvarnosti kako bi se utvrdilo na koji način je potrebno podesiti date parametre u softverima kako bi render bio veran fotografiji koja predstavlja sagledavanje prostora ljudskim okom.
SISTEM ZA AUTOMATIZACIJU UPRAVLJANJA PERSONALNIM TRENINZIMA
Authors: Milovac Dragan
Published: April 2020

U okviru ovog rada je razvijena veb aplikacija koja omogućava lakši proces vođenja i izvrša­vanja personalnih treninga. Prikazan je postupak imple­mentacije aplikacije u veb tehnologiji, ASP.NET MVC 5 koja predstavlja sastavni deo Microsoft .NET okruženja u kombinaciji sa REST servisima.
Environmental and economic processes in the European North of Russia: Sustainability Window Analysis
Authors: Shkiperova G.T. , Druzhinin P.V. , Kurilo A.E.
Published: April 2020

Subject. The article discusses issues that arise in evaluating and monitoring the transition to sustainable development, being important aspects researchers and politicians focus on. Successful planning of future growth and decision-making are recognized to require comprehensive actions addressing economic, environmental and social aspects of sustainability. The analysis of the sustainability window seems as one of possible methods to evaluate the quality of economic growth in line with environmental and social prospects.
Objectives. The study evaluates boundaries of the sustainable economic growth of the northern regions of Russia, referring to its environmental footprint and well-being of people.
Methods. We applied methods of statistical and comparative analysis and evaluated boundaries of the sustainable development of regions with the sustainability window analysis.
Results. The sustainability window is proved to exist for all regions of the European North of Russia, except the Republic of Komi. However, GRP grew out of the sustainability limits in certain years. The lower bound of the sustainable economic development slowly decreased until 2013, but reassumed its growth afterwards. After 2013 an expected increase in the public well-being required higher rates of economic growth. Some regions failed to ensure them.
Conclusions and Relevance. The analysis of the sustainability window and the analysis of environmental efficiency gap are critically informative for specialists in charge of planning and decision-makers. The method helps use various sets of indicators and analyze various time series, thus streamlining the elaboration of economic development scenarios, conditions in line with environmental and social sustainability.
Inter-regional cluster formation based on the concept of spatial development
Authors: Pronyaeva L.I. , Pavlova A.V. , Fedotenkova O.A.
Published: April 2020

Subject. This article discusses the organizational and economic processes, and conditions for the formation and development of inter-regional clusters.
Objectives. The article aims to clarify ideas and develop recommendations to assess the conditions and possibilities of inter-regional cluster forming.
Methods. For the study, we used statistical analysis, graphical, and expert assessment methods, and a literature review.
Results. The article proposes certain phases and an algorithm to form inter-regional clusters as potential economic growth zones of the regions.
Conclusions and Relevance. The inter-regional cluster formation and development should be based on the economic-growth-zone theory and models based on the principles of inclusive development and smart specialization. The results of the study may be a basis to develop a strategy for inter-regional clusters operating at the level of the country's macro-regions.
A Methodology of integrated assessment of the investment attractiveness of the priority social and economic development areas
Authors: Yakimova V.A. , Khmura S.V.
Published: April 2020

Subject. This article deals with the theoretical and methodological issues of assessing the investment attractiveness of the advanced development areas.
Objectives. The article aims to clarify the economic essence of the category Investment Attractiveness of Advanced Development Areas and related categories, and improve the methodological support to assess the investment attractiveness taking into account the characteristics of these areas.
Methods. For the study, we used the methods of analysis and synthesis, generalization, analogy, classification, grouping, and systematization.
Results. The article presents a methodology for assessing the investment attractiveness of the advanced development areas, taking into account indicators classified under three groups, namely investment potential, investment environment, and investment risk. It also offers recommendations to determine the type of investment attractiveness.
Conclusions. Investment attractiveness, as a complex characteristic of the advanced development area, gets formed in the context of the influence of internal and external factors that are quantifiable and qualitatively assessed. To meet the needs of investors, a methodology that includes current assessment and forecasts is needed, indicating the areas of possible investment risk.
English Pronunciation Practices: From Tongue Twisters to YouTube Channel
Authors: Aulia Vivi
Published: April 2020

Background: Pronunciation plays an important role to create effective communication since incorrect pronunciation may lead to misunderstanding. The EFL teachers should be aware of this issue by identifying the appropriate methods for teaching pronunciation to EFL students, with expectations; students may correctly pronounce the English words that support comprehensible communication. This research aims at describing the tongue twisters method for practicing English pronunciation as well as the YouTube channel for sharing their pronunciation practices.Methodology: This research employed an observation sheet and pronunciation task through studentsâ€™ tongue twisters video uploaded on the YouTube channel as the instruments. The observation sheet was applied to find out studentsâ€™ activities of tongue twisters practice in five meetings and their difficulties during the practice. Meanwhile, studentsâ€™ uploaded tongue twisters video on the YouTube channel was analyzed to get the result of their tongue twisters practice.Findings: The students were given 26 tongue twisters consisting of 24 English consonant sounds to pronounce four times for each of them. The result showed that tongue twisters for sounds /p/, /f/, /v/, /Ã°/, and /z/ were difficult enough for them due to the interference of their mother tongue that commonly missed on these sounds. Besides that, the highest percentage of students who got a score of 60-69 on their YouTube channel video indicates that they still need more practice.Conclusion: Having tongue twistersâ€™ practice and uploading the practice video on YouTube channel create learning experiences for students. They need to allocate more time practicing the English pronunciation better intensively. Therefore, the teachers should create maximal lesson planning and preparation to make sure that each student gets the same opportunity to practice it.
Transformation of the Ukrainian Economy in Conditions of the Crisis: some Results, Problems and Prospects
Authors: Pylin A. G.
Published: April 2020

Over the past six years since the change of political power (in February 2014) and the new leadership of the country proclaimed the course towards Euro-Atlantic integration,Ukrainehas gone through the next and the largest crisis in its post-Soviet history. This crisis was the result of not only negative global (slowdown in global economic growth, falling demand and prices for traditional Ukrainian exports), but also regional (rupture of trade and economic ties withRussia) factors amid loss of part of the territory and military operations in the east countries. Such serious external and internal shocks greatly affected to the Ukrainian economy, which at the same time withstood and largely adapted to sharply changing conditions. However, it is not necessary to talk about any significant development of the country, about its structural and technological modernization, increasing competitiveness in this period. To achieve this goal, the new authorities ofUkrainewill need to make a lot of efforts, achieve consolidation of the entire Ukrainian society on the country’s strategic development, complete large-scale structural and institutional reforms, solve the Donbass problem and at least partially restore the destroyed humanitarian and economic ties withRussia.
Russia in Turkmenistan: the Policy of Strengthening Cooperation
Authors: Garbuzarova E. G.
Published: April 2020

The article analyzes the Russian-Turkmen relations, which at the present stage are characterized by special dynamism. Thanks to the return of Russian Gazprom to the energy market ofTurkmenistanin 2019, cooperation between the two countries has intensified. The leading role of the energy factor in the relations betweenRussiaandTurkmenistanis substantiated. The problems arising in cooperation between the two countries in the oil and gas sector have a negative impact on the overall background of bilateral relations. The article considers the external and internal challenges faced byRussiain the Turkmen direction.Russia’s focus on strengthening military-political cooperation withTurkmenistanis shown. Despite the fact that the interests ofRussiaandTurkmenistanoverlap, approaches to their implementation are markedly different.Turkmenistan’s foreign policy actions are entirely determined by its domestic political priorities.Turkmenistan, fearing excessive dependence onRussiaand relying on its neutral status, is in no hurry to establish closer ties withRussia, limiting itself exclusively to the gas sphere. It is concluded that the future of Russian-Turkmen relations will largely depend on the ability of the two countries to come to agreed decisions on the oil and gas issue.
Visualization of Modern Political Space: Research Priorities
Authors: Goguadze M. G.
Published: April 2020

In modern humanitarian studies and research in a number of social sciences, interpretation of visual data is often used. However, in some cases, it is able to make a negative adjustment in the methodology and research methods, which is a consequence of the terminological and theoretical underdevelopment of the theory of visuality itself, including within the framework of political science. The development of a general visual paradigm is currently in its infancy and is being carried out through the formation of the corresponding categorical apparatus, adequate to the real processes that it signifies.

In political science studies, the theory of visibility is an innovation, since they lack the basic conceptual principles of the theory of visual political communication, which are not in demand due to the textual orientation of political science, which has for a long time linguistic-political bias, obscuring the whole complex of images in politics. However, the transformation of existing formats of rapidly developing political communication processes and technologies in the modern information society and the creation of new ones is carried out in the direction of increasing the amount of visual information that not only complements verbal forms, but also dominates the processes of political practices. The communication processes that ensure the functioning of political institutions are, in most situations, visually attributed and focused not so much on speech and audio as on visual techniques, which suggests that they are the main tool of political communication and a means of constituting political reality.
Investment tax deduction as an alternative to amortization
Authors: Shabanova Mariya Romanovna , Shumyatskii Roman Ivanovich
Published: April 2020

The object of this research is the investment tax deduction, which gives organizations the ability to reduce the calculated income tax contributing to reduction of income tax burden, freeing up finances, and allowing for faster replenishment of the capital asset fund of the organization. The subject of this research is the ability to use this deduction as an alternative to amortization. The author examines the economic impact of an organization in application of investment tax deduction and amortization withholdings based on various forms of property and international accounting standards. This article presents the results of comparative analysis of amortization withholdings and investment tax deduction. The author calculates the economic impact of application of investment deduction, methods of amortization, as well as application of amortization bonus, and studies international experience. Despite the difficulty of the question in hand from the practical perspective, in light of absence of statistical data and clarification from the Ministry of Finance of the Russian Federation, as well as case law on the application of this legislative norm, the author determines the key advantages and disadvantages of using investment deduction. The description is given to the risks of applying investment tax deduction; recommendations are formulated for using the investment tax deduction.
Comparative analysis of the factors of attractiveness for foreign direct investments in the developing and developed countries
Authors: Vasiukov Evgenii Aleksandrovich
Published: April 2020

With the cooling of global economic and exhaustion of internal sources of finance, the countries need to attract foreign investment in form of foreign direct investments (FDI) to stimulate economic growth. The subject of this research is the factors defining the inflow of foreign direct investments into national economies, as well as comparison of the factors impacting attracting of foreign capital into developing and developed countries. For comparison of the inflow of FDI, the work utilizes the following factors: openness of trade, wages, size of the market, development of infrastructure, and tax policy. In the next few years, developing countries will continue to maintain an edge in size of wages, but due to drastic difference in the quality of labor resources, developed countries will be more preferable from the investment perspective. In absence of the necessary infrastructure and without additional support or stimulus of the receiving state, decisions on investments will lean towards the more accessible markets of developed countries. As a result of limited business environment, high level of expenses for starting a company, and inefficiency of the market, the state needs to provide clear communication regarding the vector of government policy in the area of investments and refrain from inconsistency in passing measures. If companies would not be certain in the future of the political course, their profit expectations would rise significantly, while investment activity would drop.
A guarda em razão do local. É possível?
Authors: Barros Patricia Souza , Da Silva Rubens Alves
Published: April 2020

Resumo: Esse artigo buscou discutir sobre concessão de guarda da criança em razão do melhor interesse dela, tendo como ponto de partida o princípio fundamental que é o interesse da criança à luz da Constituição Federal de 1988 e o Estatuto da Criança e do Adolescente (Lei 8.069/90), sobretudo, se há a possibilidade de a guarda ser concedida em razão do local.  No discorrer do Artigo, abordarei a visão de alguns autores sobre a conceituação da guarda, conceituação de família e qual o papel dos pais diante de uma separação, quais comportamentos irão influenciar no desenvolvimento psíquico, físico e moral de um menor, bem como se há jurisprudência acerca de concessão da guarda em relação ao local, esclarecer até que ponto há legalidade em conceder guarda em razão do local em que a criança irá morar. A importância do afeto concedido pela família ainda que não seja oriundo de família biológica.
Análise funcional e radiológica de pacientes submetidos ao tratamento cirúrgico de pseudoartrose de escafóide com placa
Authors: Brito Marcelo Caio Gomes de , Martins Fausto Henrique Gonçalves , Oliveira Laurence Dias de
Published: April 2020

Objetivo: Avaliar a evolução clínica de pacientes com pseudoartrose do escafoide com tratamento cirúrgico com placa volar e enxerto córtico-esponjoso da asa do osso ilíaco. Métodos: Avaliamos sete pacientes submetidos ao tratamento cirúrgico de pseudoartrose de escafoide. Avaliamos os movimentos do punho com um goniômetro; força de preensão palmar com dinamômetro hidráulico; foi perguntado aos pacientes sua rotina de atividades após sofrer a fratura; classificamos seu nível atual de dor em uma escala analógica; avaliação funcional do membro superior baseando-se no Mayo Wrist Score além de uma avaliação das imagens de raio x. Resultados: Houve menor flexão do punho do membro acometido (média=44°) do que no membro não acometido (média=88,5°). O membro acometido alcançou 60% menos de força que o membro não acometido. Apesar disso, todos os pacientes alcançaram consolidação óssea após cirurgia, seis retornaram as atividades sem restrições e todos foram classificados pelo Mayo Wrist Score com funcionalidade boa e satisfatória. Conclusão: Este estudo demonstra à comunidade cientifica os resultados, vantagens e desvantagens da utilização de placa no tratamento da pseudoartrose de escafoide, sendo que a técnica proporciona resultados satisfatórios.
Fatores associados ao comportamento suicida em hospital psiquiátrico: estudo transversal
Authors: Olinda Krieger Rhelyni de Sousa , Santos Rosimeire Ferreira dos , Marques Thiago Henrique Costa
Published: April 2020

Objetivo: Analisar os fatores associados ao comportamento suicida em Hospital Psiquiátrico. Métodos: Estudo transversal analítico realizado em hospital de referência para tratamento de transtornos mentais graves de Teresina, no período de fevereiro a maio de 2018. A amostra foi constituída por 142 pacientes com idade igual ou superior à 18 anos e que deram entrada no serviço de urgência após de tentativa de suicídio. Para coleta de dados foi utilizado o formulário de caracterização sociodemográfica, clínica e terapêutica. A análise foi realizada com base nos princípios da estatística descritiva e inferencial e o estudo atendeu aos preceitos éticos e legais, tendo parecer emitido pelo Comitê de Ética em Pesquisa da Universidade Federal do Piauí. Resultados: Prevaleceram pacientes do sexo masculino, com idade média de 34,4, de baixa escolaridade e procedentes de Teresina. Os fatores associados foram transtorno psiquiátrico, consumo de substâncias psicoativas e tentativas prévias. Associações significativas foram verificadas entre o comportamento e variáveis sociodemográficas, clínicas e terapêuticas como sexo, idade, tentativas prévias e internação psiquiátrica. Conclusão: Fluxos assistenciais devem ser prerrogativas frequentes nos serviços de saúde, visando a identificação precoce dos determinantes e implementação de estratégias voltadas para preservação da vida, redução de riscos e dos indicadores de mortalidade.
Main Protease Inhibitors and Drug Surface Hotspot for the Treatment of COVID-19: Drug Repurposing and Molecular Docking Approach
Authors: Hasan Mahmudul , Parvez Md Sorwer Alam , Azim Kazi Faizul , Imran Abdus Shukur , Raihan Topu , Gulshan Airin , Muhit Samuel , Akhand Rubaiat Nazneen , Uddin Md Bashir , Ahmed Syed Sayeem Uddin
Published: April 2020

The world is facing an unprecedented global pandemic caused by the novel SARS-CoV-2. In the absenceof a specific therapeutic agent to treat COVID-19 patients, the present study aimed to virtually screen outthe effective drug candidates from the approved main protease protein (MPP) inhibitors and theirderivatives for the treatment of SARS-CoV-2. Here, drug repurposing and molecular docking wereemployed to screen approved MPP inhibitors and their derivatives. The approved MPP inhibitors againstHIV and HCV were prioritized, whilst hydroxychloroquine, favipiravir, remdesivir, and alpha-ketoamidewere studied as control. The target drug surface hotspot was also investigated through the moleculardocking technique. ADME analysis was conducted to understand the pharmacokinetics and drug-likenessof the screened MPP inhibitors. The result of this study revealed that Paritaprevir (-10.9 kcal/mol), and itsanalog (CID 131982844)(-16.3 kcal/mol) showed better binding affinity than the approved MPP inhibitorcompared in this study including favipiravir, remdesivir, and alpha-ketoamide. A comparative study amongthe screened putative MPP inhibitors revealed that amino acids T25, T26, H41, M49, L141, N142, G143,C145, H164, M165, E166, D187, R188, and Q189 are at critical positions for becoming the surface hotspotin the MPP of SARS-CoV-2. The study also suggested that paritaprevir and its' analog (CID 131982844),may be effective against SARS-CoV-2 as these molecules had the common drug-surface hotspots on themain protease protein of SARS-CoV-2. Other pharmacokinetic parameters also indicate that paritaprevirand its top analog (CID 131982844) will be either similar or better-repurposed drugs than already approvedMPP inhibitors.
Disentangling Viral Entry Kinetics Using Lipid Bilayers Coating Silica Nanoparticles
Authors: Villamil Giraldo Ana M. , Kasson Peter
Published: April 2020

Enveloped viruses infect cells via fusion between the viral envelope and a cellular membrane. This membrane fusion process is driven by viral proteins, but slow stochastic protein activation dominates fusion kinetics, making it challenging to probe the role of membrane mechanics in viral entry directly. We have used bilayer-coated silica nanoparticles to restrict the deformability of lipid membranes in a controllable manner. These bilayer-coated nanoparticles are then used in a single-particle fusion assay with infectious influenza virus. We observe that as we vary the free energy of membrane deformation by changing nanoparticle size, we obtain a corresponding response in fusion kinetics and apparent fusion protein stoichiometry. We thus directly measure the effect of membrane deformability on the free-energy barrier to membrane fusion by influenza, overcoming the masking effect of slow protein activation kinetics.
In Silico Identification of Widely Used and Well Tolerated Drugs That May Inhibit SARSCov- 2 3C-like Protease and Viral RNA-Dependent RNA Polymerase Activities, and May Have Potential to Be Directly Used in Clinical Trials
Authors: Gul Seref , Ozcan Onur , asar sinan , Okyar Alper , Barıs Ibrahim , Kavakli Ibrahim Halil
Published: April 2020

We performed repurposing of FDA approved drugs against SARS-CoV-2 3 chymotrypsin like protease and RNA-dependent RNA polymerase. During the screening, 3948 drugs approved by the U.S. Food and Drug Administration (FDA) to target the active site of 3CLpro and nsp8 binding sites of RdRp and, in turn, disturb SARS-CoV-2 life cycle in host cell. As a result of molecular docking and moleculardynamics simulations, several drugs with high binding affinity to both SARS-Cov-2 3CLpro and RdRp targets were identified. While drugs such as tetracycline and its derivatives, dihydroergotamine, ergotamine, dutasteride, nelfinavir, paliperidone, and conivaptan were identified to bind SARS-Cov-2 3CLpro; tipranavir, nelfinavir, dihydroergotamine, conivaptan, dutasterid and eltrombopag were found to bind nsp8 binding site of RdRp. Notably, further analysis of the results showed that ergotamine,dihydroergotamine, conivaptan, paliperidone, and tipranavir can bind to both enzymes with high affinity. Since these drugs are well tolerated, cost-effective and widely used, our study suggested that tetracycline and its derivatives, dutasteride, ergotamine, bromocriptine, tipranavir, conivaptan, paliperidone, eltrombopag drugs have the potential to be used alone or in combination as adjuvant forthe treatment of SARS-CoV-2 infected patients.
Comparative in vivo evaluation of marketed sustained release and optimized pulsatile formulation of propranolol hydrochloride
Authors: Vamsi krishan B  , Babu rao CH  , Saikishore V
Published: April 2020

Chrono pharmaceutical drug delivery system is devoted to the availability of active on a pace that idyllically matches biological requisite of disease treatment. It embodies time controlled and site-specific drug delivery systems, subsequently optimizing therapeutic action and lessening side-effect’s. In the present study optimized pulsatile formulation of Propranolol Hydrochloride ought to deliver drug at pre-set pattern at right time and site is evaluated for pharmacodynamic and pharmacokinetic performance after oral administration and compared with an existing marketed sustained formulation of Propranolol Hcl. The study was carried out in male New Zealand albino rabbits through cross over design pattern and levels of plasma measured by means of LC-MS/MS method. Pharmacokinetic parameters of designed pulsatile formulation was measured and observed to have statistical significance with existing marketed sustained formulation. The In-house pulsatile dosage form able to show lag phase and the mean residence time of pulsatile dosage form (23.20.14h.) was found to be beyond the marketed sustained dosage form (14.8 0.01h.). Pharmacokinetic data revealed a maximum guard against adrenaline levels at 6 h post oral intake and dropped to 50% after 12 h with Marketed formulation. Whereas in case of pulsatile formulation administration a maximum protection was obtained at 12 h. and continued over a period of 18 h. It is concluded that the designed pulsatile formulation offers a promising way of drug release for a programmed time period at desired site, once the administration time and pulse time are aligned with circadian pattern.
Preparation and evaluation of matrix type gastro retentive floating atenolol tablets using sintering technique.
Authors: Munagala Gayatri Ramya  , Kothapalli Bannoth Chandra Sekhar
Published: April 2020

The aim of this investigation was to design and assess the gastric floating tablets of Atenolol using thermal sintering and investigate the effect of sintering on PEO polymer. Atenolol is an Antihypertensive with only 50 percent bioavailability due to poor absorption in lower GI tract. Gastro retentive Floating tablets were prepared to enhance the gastric retention time, to prolong the drug release. PEO which was selected as sintered polymer. Tablets were prepared by direct compression method .Formulated tablets were exposed to different temperatures (400C, 500C and 600C)  at various time intervals( 1h ,2h ,3h and4h) in a hot air oven .Post compression parameters were evaluated like weight variation, hardness, friability, floating lag time and total floating time. The result of the investigation indicates sintering influenced the floating time and dissolution properties. Weight variation, friability and content uniformity values were within limits. Sintering time and temperature contributes to effectiveness of polymers in extending drug release. Reduction in floating lag time and increase in total floating time as well as release of drug was delayed. All sintered formulation have no interaction was found in FTIR, DSC studies. All sintered tablets followed zero order with nonfickian diffusion mechanism. This study helps the use of thermal sintering in preparation of floating tablets.
In Silico Studies On Colon Cancer Against Hexadecane, Hexadecanoic Acid Methyl Ester And Quinoline, 1,2-Dihydro-2,2,4-Trimethyl Compounds From Brown Seaweed
Authors: Swarna Bharathi D  , Boopathy Raja A
Published: April 2020

The main objective of this was to evaluate the potential drug for treating colon cancer and compound must be extracted from natural source especially in seaweed. The above mentioned compounds taken from GC-MS studies of Dictyotabartayresiana. There are more number of compounds present in GC-MS analysis but hexadecane, hexadecanoic acid methyl ester and quinoline, 1,2-dihydro-2,2,4-trimethyl compounds have shown best acivities compared to others that proven in previous research. NIST and SDBS databases are helps to draw the compound structure, name, fragments, molecular weight, chemical formula, hydrogen bond donor and acceptor count. The protein were obtained from PDB (Research Collaboratory for Structural Bioinformatics, Protein Data Bank) which is repository for 3D structural data of large biological macromolecules. Auto Dock tools was utilized to generate grids, calculate dock score and evaluate the conformers of activators bound in the active site of protein as targets. The compound hexadecanoic acid methyl ester (C17 H34 O2)  has the binding affinity of -6.60 kcal/mol that similar to results obtained from Quinoline, 1,2-dihydro-2,2,4-trimethyl- (C12 H15N) and Hexadecane (C16H34) shows the binding affinity of -6.20 kcal/mol which greater than standard drug 5-fluorouracil (C4H3FN2O2). In present study technically proven the anticancer property of Dictyotabartayresiana. To conclude, these resulting compounds are might be an alternate to synthetic anticancer drugs available in the market.
Gestasyonel diabeti olan ve olmayan gebe kadınlarda serum leptin konsantrasyonlarıyla vücut yağ oranı değerlerinin kıyaslanması ve insülin direnci ile insülin duyarlılığı ile ilişkisi
Authors: YILMAZ Özgür , DEMİR Namık , KÜME Tuncay
Published: April 2020

Amaç: Gestasyonel diabet ile obesite gebelikte sık görülen metabolik bozukluklar arasında yer almaktadır. Leptin başlıca yağ dokusu hücreleri tarafından üretilerek dolaşıma salınan bir peptiddir. Leptin’in karbonhidrat metabolizması ve insülin direnci üzerine tanımlanmiş birçok etkileri bildirilmiştir; ancak gestasyonel diabet ile arasındaki ilişkiye ait veriler kısıtlıdır. Bundan ötürü bu çalışmada sağlıklı ve gestasyonel diabetli gebelerdeki vücut yağ yüzdesi, serum insülin ve leptin düzeylerinin kıyaslanarak gestasyonel diabet üzerine olası etkilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Bu çalışmada 26 ile 36. gebelik haftaları arasındaki 49 gestasyonel diabetli ve 37 sağlıklı gebe incelendi. Vücut kitle indeksi ve cilt kıvrım kalınlıkları ölçüldü. Vücut yağ yüzdesi Siri formülüyle hesaplandı. Serum açlık glukoz, insülin ve leptin seviyeleri ölçüldü. İnsülin duyarlılığının değerlendirilmesinde QUICKI-IS, insülin direncinin değerlendirilmesinde ise HOMA-IR indeksleri kullanıldı. Bulgular: Gebelik haftası, yaş ve vücut kitle indeksi bakımından her iki grup arasında anlamlı fark bulunmadı (p>0.05). Gestasyonel diabetli gebelerde Vücut yağ yüzdesi (p=0.007), serum insülin (p=0.004) , leptin düzeyleri (p=0.044) ve HOMA–IR (p<0.001) sağlıklı gebelere kıyasla daha yüksek saptanırken; QUICKI-IS ise anlamlı derecede düşük bulundu (p<0.001). Korelasyon analizinde vücut yağ oranı ile serum leptin (p<0.001), insülin (p=0.04) ve HOMA-IR arasında (p=0.04) anlamlı pozitif korelasyon; QUICKI-IS ile ise (p<0.001) anlamlı ters korelasyon bulundu. Sonuç: Gestasyonel diabetli gebelerde sağlıklı gebelere kıyasla artmış olan vücut yağ oranı; leptin düzeylerinin ve insülin direncinin artmasına, insülin duyarlılığının ise azalmasına yol açabileceği düşünülmüştür. Cilt kıvrım kalınlığı ölçülerek vücut yağ yüzdesinin hesaplanması, günlük klinik uygulamalarda gebeler için güvenilir, ucuz ve uygun bir yöntem gibi görünmektedir.
Doğuştan kalp hastalığı olan çocuklarda ağız-diş sağlığı durumu ve ebeveynlerinde infektif endokardit farkındalık düzeyleri
Authors: YILMAZ Melis , SERİN Ayşe Buse , ÖZYURT Abdullah , KARPUZ Derya , HALLIOĞLU KILINÇ Olgu
Published: April 2020

Amaç: Bu çalışmada, doğuştan kalp hastalığı olan çocukların ağız-diş sağlığı durumlarının sağlıklı kontrollerle karşılaştırılması ve hasta çocukların ebeveynlerinin infektif endokardit (İE) bilgi düzeyinin ve İE’den korunma yolları farkındalıklarının değerlendirilmesi amaçlanmıştır. Yöntem: Prospektif, kontrollü bir çalışma olarak planlanan bu kohorta doğuştan kalp hastalığı ile izlenen, yaşları 5-18 yaş arası 71 hasta ve 70 kontrol grubu olmak üzere 141 çocuk dahil edildi. Ebeveynlerin hastalık ve İE ile ilgili bilinç düzeyleri soru-cevap şeklinde anket formuna not edildi. Anket cevapları; biliyor, bilmiyor, eksik biliyor, yanlış biliyor şeklinde 4 farklı seçenekten oluşturuldu. Ağız içi muayene; Plak İndeksi (Pİ), Gingival İndeks (Gİ) ve DMFT-dmft İndekslerine göre değerlendirildi. Bulgular: Çalışma grubunda ebeveynlerin sadece 24'ü (%33,8) endokarditi bildiğini söyledi fakat bunların sadece 6'sı (%8.5) doğru olarak biliyordu. Ebeveynlerin 36’sı (%50.7) ise ağız-hijyeni ile endokardit ilişkisini biliyordu. Çalışma ve kontrol grupları arasında Pİ,Gİ, DMFT-dmft indeksi değerleri arasında istatistiksel olarak anlamlı bir fark saptanmadı. Sonuç: Bu çalışmada kalp hastalığı olan hastaların ebeveynlerinde İE’den korunmak için iyi bir ağız hijyeninin önemine ilişkin farkındalık düzeyinin yetersiz olduğu görülmüştür. Yanı sıra; Pİ, Gİ, DMFT indeksleri açısından gruplar arasında istatistiksel olarak herhangi bir anlamlı fark saptanmamıştır.
Строение разнолигандных дипивалоилметанатных комплексов магния c пропилендиамином и его производным
Authors: Викулова Е.С. , Рихтер Э.А. , Пирязев Д.А. , Жерикова К.В. , Морозова Н.Б.
Published: April 2020

Методом РСА установлено строение двух разнолигандных комплексов [Mg(Q)(thd)2]: thd = 2,2,6,6-тетраметилгептан-3,5-дионат-ион (дипивалоилметанат-ион), Q = пропан-1,3-диамин (pda), N,N,N',N'-тетраметилпропан-1,3-диамин (tmpda). Структура комплекса с tmpda определена при 296 K, с pda — при 296 K и 150 K. Кристаллографические данные (296 K) для [Mg(pda)(thd)2] I: пространственная группа P–1, a = 9.6363(3) Å, b = 12.1063(4) Å, c = 14.3401(5) Å, α = 70.6430(10)°, β = 72.7680(10)°, γ = 89.376(2)°, V = 1500.41(9) Å3, Z = 2; для [Mg(tmpda)(thd)2] II: пространственная группа С2/с, a = 10.3716(3) Å, b = 17.3614(4) Å, c = 19.1577(5) Å, β = 90.8480(10)°, V = 3449.26(16) Å3, Z = 6. Кристаллические упаковки образованы моноядерными молекулами, которые в структуре I объединены в димеры за счет водородных связей N—H…O. Атомы магния находятся в искаженно-октаэдрическом координационном окружении. Длины связей Mg—O в молекулах I и II сопоставимы и варьируют в интервалах 2.027—2.062 Å и 2.023—2.030 Å соответственно; хелатные углы OMgO близки к 86°. Длина связей Mg—N и угол NMgN в комплексе II заметно больше по сравнению с I: 2.331 vs. 2.193—2.229 Å; 89.6 vs. 84.7°. Проведен сравнительный анализ строения молекул и кристаллических упаковок родственных комплексов [Mg(Q)(thd)2] с диаминами пропиленового и этиленового ряда.
Acid-base balance parameters of follicular fluid and venous blood in cattle
Authors: Indrová Eva , Andrlíková Michaela , Bína Vladislav , Doležel Radovan , Lopatářová Miloslava , Novakova Jana , Zavadilová Marta , Čech Svatopluk
Published: April 2020

The study aimed to compare differences of physiological acid-base balance (ABB) parameters in follicular fluid (FF) and venous blood (VB) and to evaluate ABB parameters in FF collected from different ovarian follicles in dairy cows and heifers. The ABB parameters (pH, pCO2, pO2, HCO3– and base excess (BE)) in the FF of the preovulatory follicle, of the dominant follicle on the 9th day of the cycle and of the superovulatory estrous follicles were compared to VB. Similarly, the dynamics of the ABB profile in FF and VB were monitored in repeated sampling in a group of heifers stimulated by follicle-stimulating hormone (FSH). Higher values of pH and pO2 and lower values of pCO2, HCO3– and BE were found in FF compared to VB in all experiments. Laterality of ovaries, time of sampling, ovarian activity or stimulation of the follicular development by FSH did not significantly influence ABB parameters. We found higher pH (7.392 ± 0.027 vs. 7.364 ± 0.032) and pO2 (13.83 ± 2.20 kPa vs. 4.50 ± 0.67 kPa), lower pCO2 (5.70 ± 0.39 kPa vs. 6.54 ± 0.61 kPa), HCO3– (25.51 ± 1.52 mmol/l vs. 26.86 ± 2.12 mmol/l) and BE (1.14 ± 1.57 mmol/l vs. 1.95 ± 2.2 mmol/l) in FF compared to VB in all non-stimulated cows. Similar relationships between FF and VB were found in all FSH stimulated cows. The study provides as yet unknown knowledge on the physiology of follicular fluid in cattle.
Selected freshness indices of skin and wings from organic chicken packaged in modified atmosphere
Authors: Abdullah Fouad Ali Abdullah , Buchtová Hana
Published: April 2020

This study is part of a project aiming to optimize storage conditions for organic chicken meat. Selected indices of skin and wings from organic chicken were evaluated. A total of 24 samples were packaged in MAP-O2 (80% O2/20% CO2), 24 samples in MAP-N2 (70% N2/30% CO2) and 48 samples as a control. The samples were analysed on days 2, 7, 10 and 14 of storage during a 14-day storage period at 2 ± 2 °C. The surface colour of skin (L*a*b*), ammonia content, thiobarbituric acid reactive substances content (TBARS) and antioxidant capacity were assessed. The lightness values (L*) for chicken skin in MAP-O2 were increased on days 7 and 10 of the storage period, and were significantly (P < 0.05) higher than in the samples in MAP-N2 and the control. Significant increases of TBARS were observed in the samples in MAP-O2 from day 7 and these values continued to increase until the end of the storage period. The antioxidant capacities of the samples in MAP-O2 were mostly lower than those of the samples in MAP-N2. Our results indicate that MAP-O2 only had a positive effect on skin colour, whereas MAP-N2 maybe preferable for shelf-life prolongation.
INTEGRATED APPROACH TO AESTHETIC EDUCATION OF SCHOOLCHILDREN IN THE PEOPLE'S REPUBLIC OF CHINA
Authors: Ionova Olena , Luparenko Svetlana , Lakhmotova Yuliia
Published: April 2020

The article is dedicated to revelation of the peculiarities of integrated approach in the process of schoolchildren's aesthetic education in the People's Republic of China. The possibilities of using art while teaching different subjects (Mathematics, different languages, Literature, History etc.) have been outlined. The Chinese pedagogues underline the close connection of Mathematics and Music. It provides opportunities to
learn fractional nature of the notes, feel the rhythm of the music, relate harmony, intervals, melody and notes to whole numbers, proportions, arithmetic operations, logarithms, Geometry and Trigonometry. The authors have pointed out that aesthetic subjects (music, art, theatre) are also closely connected in educational process of schools.
The characteristic feature of schoolchildren's aesthetic education in the People's Republic of China is taking into account the regionality (differences in development of art depending on the region of the country). It is due to different historical, socio-economic and cultural factors of development of different regions in China. The regionality strengthens the connection of arts with History, Economics and Geography and helps schoolchildren to understand the significance and differences of regional music in China, to learn various Chinese musical instruments, folk lullabies and to investigate the important characteristic features of the Chinese music. So, schoolchildren's aesthetic education in China has a strong national basis: art is connected with national expression, development of musical traditions, nature and mental aesthetic ideas.
FORMS AND METHODS OF INTERACTION OF SCHOOL AND LOCAL SELF-GOVERNMENT IN THE PROCESS OF SCHOOLCHILDREN'S CIVIC EDUCATION
Authors: Zhadko Olena
Published: April 2020

The article is dedicated to the revelation of forms and methods of interaction of school and local self-government when implementing schoolchildren's civic education.
The main forms and methods of this interaction are: support of the activities of socially active schools aimed at providing the academic, health maintaining, entertaining and social services and providing training programs for people's professional activity, ensuring the implementation of projects and programs in civic education (in particular, Swiss-Ukrainian project "Development of Citizenship Competences in Ukraine", Ukrainian project "Zero Waste School", youth project "Deputy quest" etc.), support of the activities of regional youth school organizations ("Youth Parliamentary Club", in particular), conducting actions on schoolchildren's civic education (for instance, "For a Clean Environment", "Citizen" etc.), organization and facilitation of the work of museums, holding children's festivals, regional contests dedicated to different educational and cultural problems, schoolchildren's competitions in subjects, competitions (tourism and local history, sporting, intellectual etc.), tournaments, festivals, games, meetings, excursions and exhibitions dedicated to important dates and events in the life of the country, its history, outstanding people and nature, seminar-practicum in youth civic education, production and distribution of information materials about native land. Due to above-mentioned forms and methods of interaction of school and local self-government, schoolchildren can take active part in community life, introduce non-standard, innovative approaches to solving the problems of local communities and modern managerial and information technologies in local government.