bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence and risk factors for high-level BK viruria: a single center study in China
Authors: Xiong Rui , Ye Haimin , Liu Zhujing , Li Xinchang
Published: November 2020

Background

BK virus allograft nephropathy is a serious complication after kidney transplantation, and the effect of pre-emptive intervention for high-level BK viruria has been verified, but protocols after kidney transplantation for early identification of high-level viruria are lacking.

Methods

This was a single-center study. The clinical data of the kidney transplant recipients and their donors in our center from January 1, 2015 to December 31, 2018, were collected. The patients were divided into the high-level BK viruria group (Group A) and a non-high-level BK viruria group (Group B) according to the qPCR results of BK virus DNA loads in urine samples. Significant variables were screened out by univariate analysis, and then the results were incorporated into a multivariate logistic regression model to analyze the independent risk factors for high-level BK viruria.

Results

A total of 262 recipients were included in the study. The incidence of high-level BK viruria was 13.4% (n = 35), and the median time of detection was 181 (range 91–1119) days. Univariate analysis showed that donor type ($$\chi^{2}$$

χ
2

 = 21.770, P < 0.001), history of ATG/ATG-F application ($$\chi^{2}$$

χ
2

 = 4.543, P = 0.033), acute rejection (AR) ($$\chi^{2}$$

χ
2

 = 8.313, P = 0.004) and delayed graft function (DGF) ($$\chi^{2}$$

χ
2

 = 21.170, P < 0.001) were related to high-level BK viruria. After the inclusion of the multivariate logistic regression model, the results showed deceased brain and cardiac donors (P = 0.032, OR = 3.927, 95% CI 1.122–13.746), AR (P = 0.022, OR = 4.709, 95% CI 1.253–17.697) and DGF (P = 0.001, OR = 6.682, 95% CI 2.288–19.518).

Conclusions

Donation by deceased brain and cardiac patients, history of AR and DGF were independent risk factors for high-level BK viruria after kidney transplantation.
The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method
Authors: Taylor-Just Alexia J. , Ihrie Mark D. , Duke Katherine S. , Lee Ho Young , You Dorothy J. , Hussain Salik , Kodali Vamsi K. , Ziemann Christina , Creutzenberg Otto , Vulpoi Adriana , Turcu Flaviu , Potara Monica , Todea Milica , van den Brule Sybille , Lison Dominique , Bonner James C.
Published: November 2020

Background

Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties of MWCNTs need to be identified. Functionalization has been shown to either decrease or increase MWCNT-related pulmonary injury, depending on the type of modification. We, therefore, investigated both acute and chronic pulmonary toxicity of a library of MWCNTs derived from a common pristine parent compound (NC7000).

Methods

MWCNTs were thermally or chemically purified and subsequently surface functionalized by carboxylation or amination. To evaluate pulmonary toxicity, male C57BL6 mice were dosed via oropharyngeal aspiration with either 1.6 or 4 mg/kg of each MWCNT type. Mitsui-7 MWCNT was used as a positive control. Necropsy was performed at days 3 and 60 post-exposure to collect bronchoalveolar lavage fluid (BALF) and lungs.

Results

At day 3 all MWCNTs increased the number of neutrophils in BALF. Chemical purification had a greater effect on pro-inflammatory cytokines (IL-1β, IL-6, CXCL1) in BALF, while thermal purification had a greater effect on pro-fibrotic cytokines (CCL2, OPN, TGF-β1). At day 60, thermally purified, carboxylated MWCNTs had the strongest effect on lymphocyte numbers in BALF. Thermally purified MWCNTs caused the greatest increase in LDH and total protein in BALF. Furthermore, the thermally purified and carboxyl- or amine-functionalized MWCNTs caused the greatest number of granulomatous lesions in the lungs. The physicochemical characteristics mainly associated with increased toxicity of the thermally purified derivatives were decreased surface defects and decreased amorphous content as indicated by Raman spectroscopy.

Conclusions

These data demonstrate that the purification method is an important determinant of lung toxicity induced by carboxyl- and amine-functionalized MWCNTs.
Fully-customized distraction assembly for maxillofacial distraction osteogenesis: a novel device and its experimental accuracy verification
Authors: Kang Sang-Hoon , Tak Hye-Jin , Park Ha-Won , Kim Jin-Ung , Lee Sang-Hwy
Published: November 2020

Background

A new distraction osteogenesis assembly system comprising a fully customized CAD/CAM-based fixation unit and ready-made distraction unit was developed. The aim of this study was to introduce our new distraction system and to evaluate its accuracy level in a sampled mandibular distraction osteogenesis.

Methods

Our system consists of a fully customized CAD/CAM-based fixation plate unit with two plates for each moving and anchoring part, and a ready-made distraction unit with attachment slots for fixation plates. The experimental distractions were performed on 3D-printed mandibles for one control and two experimental groups (N = 10 for each group). All groups had reference bars on the chin region and teeth to measure distraction accuracy. The control group had the classical ready-made distraction system, and experimental groups 1 and 2 were fitted with our new distraction assembly using a different distractor-positioning guide design. All distracted experimental mandibles were scanned by CT imaging, then superimposed on a 3D simulation to get their discrepancy levels.

Results

The measured 3D distances between the reference landmarks of the surgical simulations and the experimental surgeries for the three groups were significantly different (p < 0.0001) by statistical analysis. The errors were greater in the control group (with a total average of 19.18 ± 3.73 mm in 3D distance between the simulated and actual reference points) than those in the two experimental groups (with an average of 3.68 ± 1.41 mm for group 1 and 3.07 ± 1.39 mm for group 2). The customized distraction assembly with 3D-printed bone plate units in group 1 and 2, however, did not show any significant differences between simulated and actual distances (p > 0.999).

Conclusion

Our newly-developed distraction assembly system with CAD/CAM plate for the distraction osteogenesis of the mandible produced a greater level of accuracy than that of a conventional distraction device. The system appears to address existing shortcomings of conventional distraction devices, including inaccuracy in vector-controlled movement of the system. However, it also needs to be further developed to address the requirements and anatomical characteristics of specific regions.
Controlled fracture of the medial wall versus structural autograft with bulk femoral head to increase cup coverage by host bone for total hip arthroplasty in osteoarthritis secondary to developmental dysplasia of the hip: a retrospective cohort study
Authors: Mou Ping , Liao Kai , Chen Hui-lin , Yang Jing
Published: November 2020

Background

Many methods have been proposed to increase cup coverage by host bone during primary total hip arthroplasty (THA) in hip osteoarthritis secondary to developmental dysplasia of the hip (DDH). However, there was no study comparing the results of controlled fracture of the medial wall with a structural autograft with a bulk femoral head.

Methods

Sixty-seven hips classified as Crowe II/III were retrospectively included in this cohort study, which consisted of 33 controlled fractures (group A) and 34 structural autografts (group B). The Harris Hip Scores (HHS) were recorded. The radiological assessments were analyzed. Also, complications are assessed. The paired-samplettest was used for data analysis before and after the operation, while the independent sampleTtest was used for the comparison between the two groups. The Pearson chi-square test or the Fisher exact test was used to analyze the qualitative comparative parameters. Kaplan-Meier was utilized in the analysis of survivorship with the end points as a revision for any component.

Results

All patients were reconstructed acetabulum at the anatomical location. HHS increased greatly for both groups (p= 0.18). No statistic difference was observed for the two groups in postoperative leg-length discrepancy (0.51 ± 0.29 cm for group A and 0.46 ± 0.39 cm for group B,p= 0.64 ), postoperative height of the hip center (2.25 ± 0.42 cm for group A and 2.09 ± 0.31 cm for group B,p= 0.13), and inclination of the cup (39 ± 4° for group A and 38 ± 3° for group B,p= 0.65 ). The rate of cup coverage for group B (94 ± 2%) was better than for group A (91 ± 5%), (p= .009). The rate of cup protrusio was 48 ± 4% for group A. For both groups, no statistical difference was observed in the cup diameter (p> .05), while group A showed less operation time than group B (p< .001). No complications were observed at the latest follow-up.

Conclusion

Controlled fracture of the medial wall to increase cup coverage by host bone at the anatomical location can act as an alternative technique for DDH Crowe II/III with the advantage of shorter operation time and less technically demanding.
Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia
Authors: Hara Naoyuki , Morino Hiroyuki , Matsuda Yukiko , Satoh Kenichi , Hashimoto Kouichi , Maruyama Hirofumi , Kawakami Hideshi
Published: November 2020

Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountered a patient with the p.Arg1715His mutation, suffering from intractable resting tremor, particularly head tremor. This symptom improved with the administration of low-dose of zonisamide (ZNS), a T-type calcium channel blocker effective for treating Parkinson’s disease and epilepsy. Previous electrophysiological studies showed that the voltage dependence of this mutant CaV3.1 was shifted toward the positive potential. This abnormal shift was considered a factor related to disease onset and symptoms. In this study, we performed whole-cell recordings of GFP-expressing HEK293T cells that expressed wild-type or mutant CaV3.1 and investigated the changes in the abnormal shift of voltage dependence of the mutant CaV3.1. The results showed that ZNS in an amount equivalent to the patient’s internal dose significantly ameliorated the abnormal shift in the mutant CaV3.1, giving values close to those in the wild-type. On the other hand, ZNS did not affect the voltage dependence of wild-type CaV3.1. Because CaV3.1 is known to be involved in tremogenesis, modulation of the voltage dependence of mutant CaV3.1 by ZNS might have contributed to improvement in the intractable tremor of our patient with SCA42. Moreover, efonidipine, another T-type calcium channel blocker, had no effect on tremors in our patient with SCA42 and did not improve the abnormal shift in the voltage dependence of the mutant CaV3.1. This indicates that ZNS is distinct from other T-type calcium channel blockers in terms of modulation of the voltage dependence of the mutant CaV3.1.
StudiCare mindfulness—study protocol of a randomized controlled trial evaluating an internet- and mobile-based intervention for college students with no and “on demand” guidance
Authors: Küchler Ann-Marie , Schultchen Dana , Pollatos Olga , Moshagen Morten , Ebert David D. , Baumeister Harald
Published: November 2020

Background

College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by internet- and mobile-based interventions (IMIs). However, adherence of IMIs is a concern. While guidance might be a solution, it is resource-intensive, derailing potential implementation on population level. The first aim of this trial is to evaluate the efficacy of the IMI StudiCare Mindfulness (StudiCare-M) for college students with “on demand” and no guidance. The second aim is to examine potential moderators and mediators, contributing to the questions of “how” and “for whom” such interventions work.

Methods

In this three-armed randomized controlled trial, both an unguided and “guidance on demand” (GoD) condition of StudiCare-M are compared to a waitlist control group. StudiCare-M is based on principles of acceptance and commitment therapy and stress management and consists of 7 modules plus two booster sessions. Participants in the GoD condition may ask their e-coach for support whenever needed. A total of 387 college students with moderate to low mindfulness are recruited at 15+ cooperating universities in Germany, Austria, and Switzerland via circular emails. Assessments take place before as well as 1, 2, and 6 months after randomization. The primary outcome is mindfulness. Secondary outcomes include stress, depression, anxiety, interoception, presenteeism, wellbeing, intervention satisfaction, adherence, and potential side effects. Among examined moderators and mediators are sociodemographic variables, pre-treatment symptomatology, treatment expectancy, self-efficacy, cognitive fusion, emotion regulation, and alexithymia. All data will be analyzed according to intention-to-treat (ITT) principles.

Discussion

Providing effective interventions to help college students become more resilient can make a valuable contribution to the health and functionality of future society. If effective under the condition of minimal or no guidance, StudiCare-M offers a low-threshold potentially resource-efficient possibility to enhance college student mental health on a population level. Moderation- and mediation analyses will deliver further insights for optimization of target groups and intervention content.

Trial registration

WHO International Clinical Trials Registry Platform via the German Clinical Studies Trial Register DRKS00014774. Registered on 18 May 2018.
A randomized clinical trial of a theory-based fentanyl overdose education and fentanyl test strip distribution intervention to reduce rates of opioid overdose: study protocol for a randomized controlled trial
Authors: Jacka Brendan P. , Goldman Jacqueline E. , Yedinak Jesse L. , Bernstein Edward , Hadland Scott E. , Buxton Jane A. , Sherman Susan G. , Biello Katie B. , Marshall Brandon D. L.
Published: November 2020

Background

Opioid overdose deaths involving synthetic opioids, particularly illicitly manufactured fentanyl, remain a substantial public health concern in North America. Responses to overdose events (e.g., administration of naloxone and rescue breathing) are effective at reducing mortality; however, more interventions are needed to prevent overdoses involving illicitly manufactured fentanyl. This study protocol aims to evaluate the effectiveness of a behavior change intervention that incorporates individual counseling, practical training in fentanyl test strip use, and distribution of fentanyl test strips for take-home use among people who use drugs.

Methods

Residents of Rhode Island aged 18–65 years who report recent substance use (including prescription pills obtained from the street; heroin, powder cocaine, crack cocaine, methamphetamine; or any drug by injection) (n = 500) will be recruited through advertisements and targeted street-based outreach into a two-arm randomized clinical trial with 12 months of post-randomization follow-up. Eligible participants will be randomized (1:1) to receive either the RAPIDS intervention (i.e., fentanyl-specific overdose education, behavior change motivational interviewing (MI) sessions focused on using fentanyl test strips to reduce overdose risk, fentanyl test strip training, and distribution of fentanyl test strips for personal use) or standard overdose education as control. Participants will attend MI booster sessions (intervention) or attention-matched control sessions at 1, 2, and 3 months post-randomization. All participants will be offered naloxone at enrolment. The primary outcome is a composite measure of self-reported overdose in the previous month at 6- and/or 12-month follow-up visit. Secondary outcome measures include administratively linked data regarding fatal (post-mortem investigation) and non-fatal (hospitalization or emergency medical service utilization) overdoses.

Discussion

If the RAPIDS intervention is found to be effective, its brief MI and fentanyl test strip training components could be easily incorporated into existing community-based overdose prevention programming to help reduce the rates of fentanyl-related opioid overdose.

Trial registration

ClinicalTrials.gov NCT04372238. Registered on 01 May 2020
DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE VF): study protocol for a randomized controlled trial
Authors: Drennan Ian R. , Dorian Paul , McLeod Shelley , Pinto Ruxandra , Scales Damon C. , Turner Linda , Feldman Michael , Verbeek P. Richard , Morrison Laurie J. , Cheskes Sheldon
Published: November 2020

Background

Despite high-quality cardiopulmonary resuscitation (CPR), early defibrillation, and antiarrhythmic medications, some patients remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest. These patients have worse outcomes compared to patients who respond to initial treatment. Double sequential external defibrillation (DSED) and vector change (VC) defibrillation have been proposed as viable options for patients in refractory VF. However, the evidence supporting the use of novel defibrillation strategies is inconclusive. The objective of this study is to compare two novel therapeutic defibrillation strategies (DSED and VC) against standard defibrillation for patients with treatment refractory VF or pulseless ventricular tachycardia (pVT) during out-of-hospital cardiac arrest.

Research question

Among adult (≥ 18 years) patients presenting in refractory VF or pulseless ventricular tachycardia (pVT) during out-of-hospital cardiac arrest, does DSED or VC defibrillation result in greater rates of survival to hospital discharge compared to standard defibrillation?

Methods

This will be a three-arm, cluster randomized trial with repeated crossover conducted in six regions of Ontario, Canada (Peel, Halton, Toronto, Simcoe, London, and Ottawa), over 3 years. All adult (≥ 18 years) patients presenting in refractory VF (defined as patients presenting in VF/pVT and remaining in VF/pVT after three consecutive standard defibrillation attempts during out-of-hospital cardiac arrest of presumed cardiac etiology will be treated by one of three strategies: (1) continued resuscitation using standard defibrillation, (2) resuscitation involving DSED, or (3) resuscitation involving VC (change of defibrillation pads from anterior-lateral to anterior-posterior pad position) defibrillation. The primary outcome will be survival to hospital discharge. Secondary outcomes will include return of spontaneous circulation (ROSC), VF termination after the first interventional shock, VF termination inclusive of all interventional shocks, and number of defibrillation attempts to obtain ROSC. We will also perform an a priori subgroup analysis comparing rates of survival for those who receive “early DSED,” or first DSED shock is shock 4–6, to those who receive “late DSED,” or first DSED shock is shock 7 or later.

Discussion

A well-designed randomized controlled trial employing a standardized approach to alternative defibrillation strategies early in the treatment of refractory VF is urgently required to determine if the treatments of DSED or VC defibrillation impact clinical outcomes.

Trial registration

ClinicalTrials.gov NCT04080986. Registered on 6 September 2019.
Epigenetic modification mechanisms involved in keloid: current status and prospect
Authors: Lv Wenchang , Ren Yuping , Hou Kai , Hu Weijie , Yi Yi , Xiong Mingchen , Wu Min , Wu Yiping , Zhang Qi
Published: November 2020

Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix. However, common therapeutic approaches of keloid have limited effectiveness, emphasizing the momentousness of developing innovative mechanisms and therapeutic strategies. Epigenetics, representing the potential link of complex interactions between genetics and external risk factors, is currently under intense scrutiny. Accumulating evidence has demonstrated that multiple diverse and reversible epigenetic modifications, represented by DNA methylation, histone modification, and non-coding RNAs (ncRNAs), play a critical role in gene regulation and downstream fibroblastic function in keloid. Importantly, abnormal epigenetic modification manipulates multiple behaviors of keloid-derived fibroblasts, which served as the main cellular components in keloid skin tissue, including proliferation, migration, apoptosis, and differentiation. Here, we have reviewed and summarized the present available clinical and experimental studies to deeply investigate the expression profiles and clarify the mechanisms of epigenetic modification in the progression of keloid, mainly including DNA methylation, histone modification, and ncRNAs (miRNA, lncRNA, and circRNA). Besides, we also provide the challenges and future perspectives associated with epigenetics modification in keloid. Deciphering the complicated epigenetic modification in keloid is hopeful to bring novel insights into the pathogenesis etiology and diagnostic/therapeutic targets in keloid, laying a foundation for optimal keloid ending.
Ursodeoxycholic acid and bezafibrate were useful for steroid-refractory, immune-related hepatitis: a case report
Authors: Onishi Sachiyo , Tajika Masahiro , Bando Hideaki , Matsubara Yuki , Hosoda Waki , Muro Kei , Niwa Yasumasa
Published: November 2020

Background

Immune checkpoint inhibitors have shown clinically significant antitumor efficacy and have been approved for the treatment of various kinds of advanced malignancies. On the other hand, these immunotherapies show unique adverse events, termed “immune-related adverse events,” which are distinctly associated with conventional cytotoxic chemotherapy. Hepatotoxicity is recognized as an immune-related adverse event; prompt treatment with corticosteroids is recommended. However, some cases are refractory to steroids. Here, we report the first case (to our knowledge) of steroid-refractory immune-related hepatitis that was successfully treated with ursodeoxycholic acid and bezafibrate.

Case presentation

A 68-year-old Asian man, came to our hospital for the treatment of malignant melanoma involving the gingiva and presenting with multiple lymph node and bone metastases was administered nivolumab as a first-line treatment. Two months into treatment, the patient developed diarrhea as a result of immune-related colitis; the colitis was treated successfully with prednisolone 60 mg/ day, resulting in improvement in the patient’s symptoms. However, when steroids were being tapered, acute elevation of liver enzymes was observed. Autoimmune hepatitis was suspected as an immune-related adverse event, and treatment with intravenous prednisolone 60 mg/ day was reinitiated. However, restoration of the steroid treatment failed to improve the patient’s liver enzymes. On the basis of histological findings from liver biopsy and exclusion of other etiologies such as viral infection and other drug-induced hepatitis, steroid-refractory hepatic immune-related adverse event was deemed the most likely cause of the patient’s acute hepatitis. In general, mycophenolate mofetil or tacrolimus is known to provide benefits in cases of steroid-refractory hepatitis. We therefore decided to add oral ursodeoxycholic acid and bezafibrate in consideration of the patient’s background of repeated aspiration pneumonia. Administration of this regimen resulted in an improvement in liver function, which remained normal even after tapering of prednisolone.

Conclusions

Ursodeoxycholic acid and bezafibrate may be useful for treatment of steroid-refractory immune-related adverse event hepatitis.
A necessary and sufficient condition for sequences to be minimal completely monotonic
Authors: Wang Xi-Feng , Ismail Mourad E. H. , Batir Necdet , Guo S.
Published: November 2020

In this article, we present a necessary and sufficient condition under which sequences are minimal completely monotonic.
Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review
Authors: Arima Kazuhiko , Mizukami Satoshi , Nishimura Takayuki , Tomita Yoshihito , Nakashima Hiroki , Abe Yasuyo , Aoyagi Kiyoshi
Published: November 2020

Background

Vitamin D deficiency is associated with osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. Elderly individuals are more likely to present with poor musculoskeletal conditions. Recently, several epidemiological studies have assessed the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and musculoskeletal conditions in elderly individuals.

Main text

Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Numerous studies have shown a positive association between serum 25(OH)D levels and bone mineral density. Only a few studies have reported an association between serum 25(OH)D levels and quantitative ultrasound (QUS) parameters. Low serum 25(OH)D level may be a risk factor for hip fracture. However, data on the association between vitamin D deficiency and the incidence of non-hip fracture are contrasting. Falls are a major cause of mortality and morbidity in older adults. Several prospective population-based cohort studies have shown that low 25(OH)D levels are associated with an increased risk of falls. Reduced muscle strength and physical performance are risk factors for adverse events, including disability, institutionalization, and mortality. The role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly individuals is still controversial. Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of disability among older adults. Data on the association between serum 25(OH)D levels and OA are contrasting.

Conclusion

Some studies have shown that vitamin D deficiency may be a risk factor for poor musculoskeletal conditions, such as osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. However, other studies did not find an association between serum 25(OH)D levels and musculoskeletal conditions.
Two-point normalization for reducing inter-laboratory discrepancies in δ17O, δ18O, and Δ′17O of reference silicates
Authors: Kim Nak Kyu , Park Changkun , Kusakabe Minoru
Published: November 2020

The δ17O and δ18O values of a number of terrestrial minerals and rocks have been determined using laser fluorination method worldwide. For the comprehensive and congruous interpretation of oxygen isotope data, the δ-values should be normalized by the two-point method (i.e., the VSMOW-SLAP scale) to eliminate inter-laboratory bias. In this study, the δ17O and δ18O values of VSMOW and SLAP were measured to calibrate our laboratory working standard O2 gas. The O2 gas liberated from the water samples was purified using the preparation line normally employed for solid samples, and analyzed by the same mass spectrometer. From the analyses of VSMOW and SLAP, the oxygen isotope compositions of the international silicate standards (UWG2 garnet, NBS28 quartz, and San Carlos olivine) were normalized to the VSMOW-SLAP scale (two-point calibration), and then the Δ′17O values were determined. Using the δ-values obtained in this way, the inter-laboratory discrepancy of the δ17O and δ18O results of the silicate standards could be reduced. The VSMOW-SLAP scaling for δ17O and δ18O analysis of silicates provides the most effective way to obtain accurate and precise data. In reporting the Δ′17O values, it is important to make the choice of the reference fractionation line into account because the Δ′17O value is quite variable owing to the slope and y-intercept of the linear relation of the δ-values. The reference fractionation line obtained from the measurement of the low- and high-δ18O reference silicates would help to compare ∆′17O values. We confirmed that the ∆′17O results of the international silicate standards based on the two-point silicate reference line were consistent with the results from other laboratories.
Effect of core electrical conductivity on core surface flow models
Authors: Matsushima Masaki
Published: November 2020

The electrical conductivity of the Earth’s core is an important physical parameter that controls the core dynamics and the thermal evolution of the Earth. In this study, the effect of core electrical conductivity on core surface flow models is investigated. Core surface flow is derived from a geomagnetic field model on the presumption that a viscous boundary layer forms at the core–mantle boundary. Inside the boundary layer, where the viscous force plays an important role in force balance, temporal variations of the magnetic field are caused by magnetic diffusion as well as motional induction. Below the boundary layer, where core flow is assumed to be in tangentially geostrophic balance or tangentially magnetostrophic balance, contributions of magnetic diffusion to temporal variation of the magnetic field are neglected. Under the constraint that the core flow is tangentially geostrophic beneath the boundary layer, the core electrical conductivity in the range from$${10}^{5} ~\mathrm{S}~{\mathrm{m}}^{-1}$$105Sm-1to$${10}^{7}~ \mathrm{S}~{\mathrm{m}}^{-1}$$107Sm-1has less significant effect on the core flow. Under the constraint that the core flow is tangentially magnetostrophic beneath the boundary layer, the influence of electrical conductivity on the core flow models can be clearly recognized; the magnitude of the mean toroidal flow does not increase or decrease, but that of the mean poloidal flow increases with an increase in core electrical conductivity. This difference arises from the Lorentz force, which can be stronger than the Coriolis force, for higher electrical conductivity, since the Lorentz force is proportional to the electrical conductivity. In other words, the Elsasser number, which represents the ratio of the Lorentz force to the Coriolis force, has an influence on the difference. The result implies that the ratio of toroidal to poloidal flow magnitudes has been changing in accordance with secular changes of rotation rate of the Earth and of core electrical conductivity due to a decrease in core temperature throughout the thermal evolution of the Earth.
Solar cycle-related variation in solar differential rotation and meridional flow in solar cycle 24
Authors: Imada Shinsuke , Matoba Kengo , Fujiyama Masashi , Iijima Haruhisa
Published: November 2020

We studied temporal variation of the differential rotation and poleward meridional circulation during solar cycle 24 using the magnetic element feature tracking technique. We used line-of-sight magnetograms obtained using the helioseismic and magnetic imager aboard the Solar Dynamics Observatory from May 01, 2010 to March 26, 2020 (for almost the entire period of solar cycle 24, Carrington rotation from 2096 to 2229) and tracked the magnetic element features every 1 h. We also estimated the differential rotation and poleward meridional flow velocity profiles. The observed profiles are consistent with those of previous studies on different cycles. Typical properties resulting from torsional oscillations can also be observed from solar cycle 24. The amplitude of the variation was approximately ±10 m s$$^{-1}$$

-
1

. Interestingly, we found that the average meridional flow observed in solar cycle 24 is faster than that observed in solar cycle 23. In particular, during the declining phase of the cycle, the meridional flow of the middle latitude is accelerated from 10 to 17 m s$$^{-1}$$

-
1

, which is almost half of the meridional flow itself. The faster meridional flow in solar cycle 24 might be the result of the weakest cycle during the last 100 years.
Effect of folic acid on animal models, cell cultures, and human oral clefts: a literature review
Authors: Bendahan Zita C. , Escobar Lina M. , Castellanos Jaime E. , González-Carrera María C.
Published: November 2020

Background

Folate is a naturally occurring, water-soluble B vitamin. The synthetic form of this compound is folic acid (FA), the deficiency of which is linked to neural tube disorders (NTD), which can be prevented by consuming it before, or during the early months of, pregnancy. However, the effect of FA on oral cleft formation remains controversial. The aim of the present study was to review the evidence concerning the effect of FA on the formation of cleft lip and palate (CLP) in both animals and humans, as well as its impact on different cell types. A search was conducted on various databases, including MEDLINE, EMBASE, and Central, for articles published until January 2020.

Main body

Current systematic reviews indicate that FA, alone or in combination with other vitamins, prevents NTD; however, there is no consensus on whether its consumption can prevent CLP formation. Conversely, the protective effect of FA on palatal cleft (CP) induction has been inferred from animal models; additionally, in vitro studies enumerate a cell-type and dose-dependent effect of FA on cell viability, proliferation, and differentiation, hence bolstering evidence from epidemiological studies.

Conclusions

Meta-analysis, animal models, and in vitro studies demonstrated the protective effect of FA against isolated CP; however, the heterogeneity of treatment protocols, doses, and FA administration method, as well as the different cell types used in in vitro studies, does not conclusively establish whether FA prevents CLP formation.
Validating a Numerical Simulation of the ConsiGma(R) Coater
Authors: Boehling Peter , Jacevic Dalibor , Detobel Frederik , Holman James , Wareham Laura , Metzger Matthew , Khinast Johannes G.
Published: November 2020

Continuous manufacturing is increasingly used in the pharmaceutical industry, as it promises to deliver better product quality while simultaneously increasing production flexibility. GEA developed a semi-continuous tablet coater which can be integrated into a continuous tableting line, accelerating the switch from traditional batch production to the continuous mode of operation. The latter offers certain advantages over batch production, e.g., operational flexibility, increased process/product quality, and decreased cost. However, process understanding is the key element for process control. In this regard, computational tools can improve the fundamental understanding and process performance, especially those related to new processes, such as continuous tablet coating where process mechanics remain unclear. The discrete element method (DEM) and computational fluid dynamics (CFD) are two methods that allow transition from empirical process design to a mechanistic understanding of the individual process units. The developed coupling model allows to track the heat, mass, and momentum exchange between the tablet and fluid phase. The goal of this work was to develop and validate a high-fidelity CFD-DEM simulation model of the tablet coating process in the GEA ConsiGma® coater. After the model development, simulation results for the tablet movement, coating quality, and heat and mass transfer during the coating process were validated and compared to the experimental outcomes. The experimental and simulation results agreed well on all accounts measured, indicating that the model can be used in further studies to investigate the operating space of the continuous tablet coating process.
The Isopropylation of Naphthalene over USY Zeolite with FAU Topology. The Selectivities of the Products
Authors: Sugi Yoshihiro , Joseph Stalin , Ramadass Kavitha , Indirathankam Sathish Clastinrusselraj , Premkumar Selvarajan , Dasireddy Venkata D B C , Yang Jae-Hun , Al-Muhtaseb Ala'a H , Liu Qing , Kubota Yoshihiro , Komura Kenichi , Vinu Ajayan
Published: November 2020

The isopropylation of naphthalene (NP) over USY zeolite (FAU06, SiO2/Al2O3 = 6) gave all eight possible diisopropylnaphthalene (DIPN) isomers: β,β- (2,6- and 2,7-), α,β- (1,3-, 1,6-, and 1,7-), and α,α- (1,4- and 1,5-). The catalyses are operated under kinetic and/or thermodynamic controls depending on the reaction temperatures because the cavities of FAU topology are wide enough to form all DIPN isomers. Enhanced selectivities for β,β-DIPN were observed at the early stages at 200, 250, and 300 °C although the selectivities decreased with the increasing periods, accompanying the increase in α,α- and α,β-DIPN. The enhancement occurs under new types of thermodynamic controls through thermodynamically preferred transition states to β,β-DIPN. Triisopropylnaphthalene (TriIPN) isomers are also formed in the isopropylation. Unstable α,α,β-TriIPN (1,4,6- and 1,3,5-) is predominantly formed at lower temperatures; however, decreased with the increase of stable α,β,β-TriIPN (1,3,6- and 1,3,7-) at higher temperatures. The predominant formation of 1,4,6-TriIPN was also observed in the initial stages in the range of 200, 250 and 300 °C, as reaction period was increased, while the selectivity for the isomer was decreased with concomitant increase in the selectivities for the other isomers. These changes of the selectivities operated under kinetic and/or thermodynamic controls. Large cavities of the zeolite allow the formation of all TriIPN isomers without steric restriction.
A study of using a deep learning image reconstruction to improve the image quality of extremely low-dose contrast-enhanced abdominal CT for patients with hepatic lesions
Authors: Cao Le , Liu Xiang , Li Jianying , Qu Tingting , Chen Lihong , Cheng Yannan , Hu Jieliang , Sun Jingtao , Guo Jianxin
Published: November 2020

Objective:

To investigate the feasibility of using deep learning image reconstruction (DLIR) to significantly reduce radiation dose and improve image quality in contrast-enhanced abdominal CT.

Methods:

This was a prospective study. 40 patients with hepatic lesions underwent abdominal CT using routine dose (120kV, noise index (NI) setting of 11 with automatic tube current modulation) in the arterial-phase (AP) and portal-phase (PP), and low dose (NI = 24) in the delayed-phase (DP). All images were reconstructed at 1.25 mm thickness using ASIR-V at 50% strength. In addition, images in DP were reconstructed using DLIR in high setting (DLIR-H). The CT value and standard deviation (SD) of hepatic parenchyma, spleen, paraspinal muscle and lesion were measured. The overall image quality includes subjective noise, sharpness, artifacts and diagnostic confidence were assessed by two radiologists blindly using a 5-point scale (1, unacceptable and 5, excellent). Dose between AP and DP was compared, and image quality among different reconstructions were compared using SPSS20.0.

Results:

Compared to AP, DP significantly reduced radiation dose by 76% (0.76 ± 0.09 mSv vs 3.18 ± 0.48 mSv), DLIR-H DP images had lower image noise (14.08 ± 2.89 HU vs 16.67 ± 3.74 HU, p < 0.001) but similar overall image quality score as the ASIR-V50% AP images (3.88 ± 0.34 vs 4.05 ± 0.44, p > 0.05). For the DP images, DLIR-H significantly reduced image noise in hepatic parenchyma, spleen, muscle and lesion to (14.77 ± 2.61 HU, 14.26 ± 2.67 HU, 14.08 ± 2.89 HU and 16.25 ± 4.42 HU) from (24.95 ± 4.32 HU, 25.42 ± 4.99 HU, 23.99 ± 5.26 HU and 27.01 ± 7.11) with ASIR-V50%, respectively (all p < 0.001) and improved image quality score (3.88 ± 0.34 vs 2.87 ± 0.53; p < 0.05).

Conclusion:

DLIR-H significantly reduces image noise and generates images with clinically acceptable quality and diagnostic confidence with 76% dose reduction.

Advances in knowledge:

(1) DLIR-H yielded a significantly lower image noise, higher CNR and higher overall image quality score and diagnostic confidence than the ASIR-V50% under low signal conditions. (2) Our study demonstrated that at 76% lower radiation dose, the DLIR-H DP images had similar overall image quality to the routine-dose ASIR-V50% AP images.
Introducing a drift and diffusion framework for childhood growth research
Authors: Lewis Fraser I , Guga Godfrey , Mdoe Paschal , Mduma Esto , Mahopo Cloupas , Bessong Pascal , Richard Stephanie A , McCormick Benjamin J J
Published: November 2020

Background: Growth trajectories are highly variable between children, making epidemiological analyses challenging both to the identification of malnutrition interventions at the population level and also risk assessment at individual level. We introduce stochastic differential equation (SDE) models into child growth research. SDEs describe flexible dynamic processes comprising: drift - gradual smooth changes – such as physiology or gut microbiome, and diffusion - sudden perturbations, such as illness or infection.

Methods: We present a case study applying SDE models to child growth trajectory data from the Haydom, Tanzania and Venda, South Africa sites within the MAL-ED cohort. These data comprise n=460 children aged 0-24 months. A comparison with classical curve fitting (linear mixed models) is also presented.

Results: The SDE models offered a wide range of new flexible shapes and parameterizations compared to classical additive models, with performance as good or better than standard approaches. The predictions from the SDE models suggest distinct longitudinal clusters that form distinct ‘streams’ hidden by the large between-child variability.

Conclusions: Using SDE models to predict future growth trajectories revealed new insights in the observed data, where trajectories appear to cluster together in bands, which may have a future risk assessment application. SDEs offer an attractive approach for child growth modelling and potentially offer new insights.
Addressee Factor in Contract Military Service Advertising: Cognitive and Rhetorical Aspects of the Study of Language Persuasive Means
Authors: Pronicheva O. , Pankova I.
Published: November 2020

A cognitive-rhetorical approach to the study of persuasive techniques and means in texts of contract military service advertising is represented in the article. The article demonstrates that social advertising is a necessary form of army institutional discourse and is in search of means of persuasion, with the help of which it is possible to attract more people who want to join the ranks of the armed forces. The addressee of the advertising message becomes the most important component of the situation, while the code becomes the text focused on satisfying presuppositions, intentional expectations of the addressee. The connection of cognitive and rhetorical aspects allows us to demonstrate the possibility of the influence of the used language tools on the addressee in order to create opinions and preferences among the target audience groups that, in turn, contributes to the formation of a stable reputation of the institute in the public mind.
Differences in Fertility Patterns between East and West German Women. Disentangling the roles of cultural background and of the transformation process
Authors: Arránz Becker Oliver , Lois Daniel , Nauck Bernhard
Published: November 2020

The present study compares parity-specific fertility patterns of West and East German women (from birth cohorts 1970 and younger) after German re-unification using panel data from the GSOEP (waves 1990 through 2006). Whereas the transition rate for the birth of the first child tends to be higher in the East German than in the West German sub-sample, the likelihood of second births remains considerably higher among West German women across time. The analyses presented comprise a detailed comparative test of different intervening mechanisms, represented by sociocultural orientations and social inequalities resulting from the societal transformation process. Although the transition rate to first births among East German women is lowered by their higher education and work aspirations, their higher degree of family orientation promotes their propensity to start a family. Surprisingly, the higher proportion of persons without a denomination in East Germany promotes the transition to parenthood because it accelerates both the engagement in and the consolidation of intimate relationships. The lower transition rate to second births among East German women is partly accounted for by the higher work aspirations, by the lower religiosity and by the lower general life satisfaction in this subgroup.
The Impact of Socioeconomic Characteristics on Older Employees’ Willingness to Continue Working in Retirement Age
Authors: Micheel Frank , Roloff Juliane , Wickenheiser Ines
Published: November 2020

This article explores whether and to what degree information on the socioeconomic status – measured by professional status and disposable household income – allows making reliable statements on the willingness to remain in work in retirement age. These observations are controlled for professional and individual characteristics. The data basis is constituted by the study entitled “Continuing in employment in pensionable age” with N = 1,500 dependent employees aged from 55 to under 65. Logistic regressions show that the socioeconomic status makes a statistically-significant contribution towards explaining the willingness to continue in employment: In comparison to employees with a lower or medium professional status, those individuals who have a high professional status tended to be significantly more willing to remain in working life for longer. There is a negative connection between the disposable household income and the willingness to remain in employment in retirement age. The significant effects that were found are however restricted to the women in the study.
The Influence of Regional Social Inequality and Labour Market Characteristics on Health
Authors: Gross Christiane , Kriwy Peter
Published: November 2020

The influence of contextual factors on individual health status has been demonstrated by a number of studies even when controlling for the individual socio-economic situation (and other relevant factors). The article examines whether and to what extent variables of the place of residence have an effect on individual health status. We do not only refer to income levels and inequality, but also to effects of the educational level and inequality and the regional unemployment rate. As data basis for the individual level, we use the 2006 wave of the German Socio-Economic Panel Study (SOEP) and add regional information on the aggregate level based on the regional units (Raumordnungsregionen) of the Microcensus of 2005. These data will be analysed using multilevel models. The results reveal that regional educational inequality intensifies the individual educational effect, whereby members of less-educated groups in educationally disparate regions exhibit particularly low health chances. In addition, a high regional unemployment rate intensifies the negative effect of individual unemployment on men’s health.