bluuebunny/crossref_metadata_2025 huggingface dataset:
Mango Peels as an Industrial By-Product: A Sustainable Source of Compounds with Antioxidant, Enzymatic, and Antimicrobial Activity
Authors: Kučuk Nika , Primožič Mateja , Kotnik Petra , Knez Željko , Leitgeb Maja
Published: February 2024

Plant waste materials are important sources of bioactive compounds with remarkable health-promoting benefits. In particular, industrial by-products such as mango peels are sustainable sources of bioactive substances, with antioxidant, enzymatic, and antimicrobial activity. Appropriate processing is essential to obtain highly bioactive compounds for further use in generating value-added products for the food industry. The objective of the study was to investigate and compare the biological activity of compounds from fresh and dried mango peels obtained by different conventional methods and unconventional extraction methods using supercritical fluids (SFE). The highest total phenolic content (25.0 mg GAE/g DW) and the total content of eight phenolic compounds (829.92 µg/g DW) determined by LC-MS/MS were detected in dried mango peel extract obtained by the Soxhlet process (SE). SFE gave the highest content of proanthocyanidins (0.4 mg PAC/g DW). The ethanolic ultrasonic process (UAE) provided the highest antioxidant activity of the product (82.4%) using DPPH radical scavenging activity and total protein content (2.95 mg protein/g DW). Overall, the dried mango peels were richer in bioactive compounds (caffeic acid, chlorogenic acid, gallic acid, catechin, and hesperidin/neohesperidin), indicating successful preservation during air drying. Furthermore, outstanding polyphenol oxidase, superoxide dismutase (SOD), and lipase activities were detected in mango peel extracts. This is the first study in which remarkable antibacterial activities against the growth of Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) were evaluated by determining the microbial growth inhibition rate after 12 and 24 h incubation periods for mango peel extracts obtained by different methods. Ethanolic SE and UAE extracts from dried mango peels resulted in the lowest minimum inhibitory concentrations (MIC90) for all bacterial species tested. Mango peels are remarkable waste products that could contribute to the sustainable development of exceptional products with high-added value for various applications, especially as dietary supplements.
Physicochemical, Rheological and Sensory Evaluation of Herbal Bread Containing Turmeric, Ginger, and Black Cumin Powder
Authors: Saddique Muhammad Suffyan , Sultan Muhammad Tauseef , Iqbal Shahzad Zafar , Bosch Christine , Akhtar Saeed , Raza Hassan , Tariq Naima , Ahmed Waqas
Published: February 2024

The diversity in the global food market is expanding as thousands of new products enter the business every year, among which nutraceutical and functional foods hold important positions. The present research work aimed at the nutritional evaluation of three medicinal herbs, i.e., turmeric (Curcuma longa L.), ginger (Zingiber officinale), and black cumin (Nigella sativa). A bread formulation was enriched with the individual/combined supplementation (1–3%) of these herbs. Later, the bread was analyzed for nutritional, rheological, textural, and sensorial characteristics. The results revealed that the herbs improved the nutritional composition of bread, especially ash and fiber, as the maximum ash and fiber contents were noticed in T15 (2.0% dried powder of each plant) with values of 1.64 ± 0.04% and 4.63 ± 0.16%, respectively. The results regarding the rheological behavior showed minor variations in the rheological traits and a slight increase in dough development time up to 4.50 ± 0.20 min in T10 from 2.80 ± 0.13 min in T0. The sensorial attributes also indicated their marked suitability as external and internal characteristics were least affected by the addition of the herbs. Although some parameters like the crust and crumb colors were affected by the addition of black cumin, showing values of 6.25 ± 0.52 and 4.44 ± 0.19, respectively, in T15, and aroma characteristics were affected by the addition of ginger, supplementation with a combination of herbs at lower doses mitigated the adverse effects of other herbs. Moreover, shelf-life extension, especially with the addition of turmeric powder, was the hallmark of this research. This study concluded that medicinal herbs can be incorporated into baked products to improve the nutritional and sensorial attributes of functional herbal bread.
Nanomaterial-Based Optical Detection of Food Contaminants
Authors: Pan Mingfei
Published: February 2024

The presence of food contaminants remains a significant aspect contributing to global food safety issues, drawing widespread attention from ordinary consumers, governments, and researchers [...]
Research Progress in Modifications, Bioactivities, and Applications of Medicine and Food Homologous Plant Starch
Authors: Chen Kai , Wei Pinghui , Jia Meiqi , Wang Lihao , Li Zihan , Zhang Zhongwei , Liu Yuhuan , Shi Lin
Published: February 2024

Starchy foods are an essential part of people’s daily diet. Starch is the primary substance used by plants to store carbohydrates, and it is the primary source of energy for humans and animals. In China, a variety of plants, including edible medicinal plants, such as Pueraria root, yam tuber and coix seed, are rich in starch. However, limited by their inherent properties, kudzu starch and other starches are not suitable for the modern food industry. Natural starch is frequently altered by physical, chemical, or biological means to give it superior qualities to natural starch as it frequently cannot satisfy the demands of industrial manufacturing. Therefore, the deep processing market of modified starch and its products has a great potential. This paper reviews the modification methods which can provide excellent functional, rheological, and processing characteristics for these starches that can be used to improve the physical and chemical properties, texture properties, and edible qualities. This will provide a comprehensive reference for the modification and application of starch from medicinal and edible plants.
An In Silico In Vitro and In Vivo Study on the Influence of an Eggplant Fruit (Solanum anguivi Lam) Diet on Metabolic Dysfunction in the Sucrose-Induced Diabetic-like Fruit Fly (Drosophila melanogaster)
Authors: Nwanna Esther , Ojo Roseline , Shafiq Nusrat , Ali Awais , Okello Emmanuel , Oboh Ganiyu
Published: February 2024

Introduction: Africa faces immense food and health insecurity challenges, a problem partly attributed to food loss and waste during postharvest handling and distribution. In the context of research to meet the sustainable development goals, this project specifically addressed the postharvest loss of the ripe indigenous eggplant (Solanum anguivi lam) fruit called “Igba Yinrin” by Yoruba in South-West Nigeria, which is usually discarded in farms. The study was carried out on ripe and unripe fruits to better understand their value by comparing their effects in diabetes treatment. Methods: The study sought to assess the effects of a diet including ripe or unripe mature eggplant fruits in the sucrose-induced diabetic-like fruit fly. Bioactive compounds were identified and quantified with HPLC–UV, while the antioxidant vitamin (A, C, E), carotenoid, and mineral (Na, K, Ca, Mg, Fe, P, and Zn) content was analyzed in the fruits. Extracts were used to investigate their in vitro anti-inflammatory properties on cyclooxygenases (COX 1 and 2), 5-lipoxygenase (5-LOX), and anti-diabetes enzymes [α-amylase and α-glucosidase], while extract-supplemented diets (0.25–1% concentration) were fed to the fruit flies for 14 days. Results: Interestingly, the results showed that the ripe fruits had a significantly (p < 0.05) higher total phenol and flavonoid content, as well as a higher content of vitamins, carotenoids, and minerals, than the unripe fruits. The in vivo activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione transferase (GST)] and the total thiol level increased, while the blood glucose, reactive oxygen species (ROS), and malondialdehyde (MDA) levels decreased in Drosophila melanogaster (fruit fly). An in silico docking analysis showed strong binding affinity of the above-mentioned enzymes under investigation with the ligands hesperidin, naringin, and myricetin, which are bioactive compounds contained in the examined extracts. Conclusions: There was no significant difference in the biological effects of the ripe and unripe fruit extracts on inflammatory and anti-diabetes enzyme activities, which means that the ripe fruit, usually discarded, could serve as a sustainable alternative source of food nutrients.
Sea Buckthorn Flavonoid Extracted by High Hydrostatic Pressure Inhibited IgE-Stimulated Mast Cell Activation through the Mitogen-Activated Protein Kinase Signaling Pathway
Authors: Yan Zhuomin , Feng Xiaoping , Li Xinian , Gao Zhenpeng , Wang Zhouli , Ren Guangxu , Long Fangyu
Published: February 2024

Sea buckthorn (Hippophaë rhamnoides L.), as one of the Elaeagnaceae family, has the significant function of anti-tumor, anti-inflammation, anti-oxidation, and other physiological activities. High hydrostatic pressure (HHP) extraction has the advantages of being easy and efficient, while maintaining biological activity. In this study, sea buckthorn flavonoid (SBF) was extracted with HHP and purified sea buckthorn flavonoid (PSBF) was isolated by AB-8 macroporous resin column. HPLC analysis was used to quantified them. In addition, the effect of anti-allergy in RBL-2H3 cells by SBF, PSBF, and their flavonoid compounds was evaluated. The results demonstrate the conditions for obtaining the maximum flavonoid amount of SBF: 415 MPa for 10 min, 72% ethanol concentration, and a liquid to solid ratio of 40 mL/g, which increased the purity from 1.46% to 13.26%. Both SBF and PSBF included rutin, quercitrin, quercetin, isorhamnetin, and kaempferol. In addition, quercitrin, kaempferol, and SBF could regulate Th1/Th2 cytokine balance. Moreover, extracellular Ca2+ influx was reduced by quercitrin and PSBF. Furthermore, rutin, quercetin, iso-rhamnetin, and SBF could also inhibit P-p38 and P-JNK expression, thereby suppressing the phosphorylation of the MAPK signaling pathways. Overall, SBF is effective for relieving food allergy and might be a promising anti-allergic therapeutic agent.
Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates
Authors: Cantero-Bahillo Emma , Navarro del Hierro Joaquín , de las Nieves Siles-Sánchez María , Jaime Laura , Santoyo Susana , Martin Diana
Published: February 2024

Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts.
Error Analysis of the Nonuniform Alikhanov Scheme for the Fourth-Order Fractional Diffusion-Wave Equation
Authors: An Zihao , Huang Chaobao
Published: February 2024

This paper considers the numerical approximation to the fourth-order fractional diffusion-wave equation. Using a separation of variables, we can construct the exact solution for such a problem and then analyze its regularity. The obtained regularity result indicates that the solution behaves as a weak singularity at the initial time. Using the order reduction method, the fourth-order fractional diffusion-wave equation can be rewritten as a coupled system of low order, which is approximated by the nonuniform Alikhanov scheme in time and the finite difference method in space. Furthermore, the H2-norm stability result is obtained. With the help of this result and a priori bounds of the solution, an α-robust error estimate with optimal convergence order is derived. In order to further verify the accuracy of our theoretical analysis, some numerical results are provided.
Properties and Applications of Symmetric Quantum Calculus
Authors: Vivas-Cortez Miguel , Javed Muhammad Zakria , Awan Muhammad Uzair , Dragomir Silvestru Sever , Zidan Ahmed M.
Published: February 2024

Symmetric derivatives and integrals are extensively studied to overcome the limitations of classical derivatives and integral operators. In the current investigation, we explore the quantum symmetric derivatives on finite intervals. We introduced the idea of right quantum symmetric derivatives and integral operators and studied various properties of both operators as well. Using these concepts, we deliver new variants of Young’s inequality, Hölder’s inequality, Minkowski’s inequality, Hermite–Hadamard’s inequality, Ostrowski’s inequality, and Gruss–Chebysev inequality. We report the Hermite–Hadamard’s inequalities by taking into account the differentiability of convex mappings. These fundamental results are pivotal to studying the various other problems in the field of inequalities. The validation of results is also supported with some visuals.
Analysis and Warning Prediction of Tunnel Deformation Based on Multifractal Theory
Authors: Yang Chengtao , Huang Rendong , Liu Dunwen , Qiu Weichao , Zhang Ruiping , Tang Yu
Published: February 2024

To better analyze the fluctuation characteristics and development law of tunnel deformation data, multifractal theory is applied to tunnel deformation analysis. That is, the multifractal detrended fluctuation analysis (MF-DFA) model is first utilized to carry out the multifractal characterization of tunnel deformation data. Further, Mann–Kendall (M–K) analysis is utilized to construct the dual criterion (∆α indicator criterion and ∆f(α) indicator criterion) for the tunnel deformation early warning study. In addition, the particle swarm optimization long-short-term memory (PSO-LSTM) prediction model is used for predicting tunnel settlement. The results show that, in reference to the tunnel warning level criteria and based on the Z-value results of the indicator criterion, the warning level of all four sections is class II. At the same time, through the analysis of tunnel settlement predictions, the PSO-LSTM model has a better prediction effect and stability for tunnel settlement. The predicted results show a slow increase in tunnel settlement over the next 5 days. Finally, the tunnel warning level and the predicted results of tunnel settlement are analyzed in a comprehensive manner. The deformation will increase slowly in the future. Therefore, monitoring and measurement should be strengthened, and disaster preparedness plans should be prepared.
X-ray Polarization from Magnetar Sources
Authors: Taverna  Roberto , Turolla  Roberto
Published: February 2024

The launch of the IXPE telescope in late 2021 finally made polarization measurements in the 2–8keV band a reality, more than 40 years after the pioneering observations of the OSO-8 satellite. In the first two years of operations, IXPE targeted more than 60 sources, including four magnetars, neutron stars with magnetic fields in the petaGauss range. In this paper we summarize the IXPE main findings and discuss their implications for the physics of ultra-magnetized neutron stars. Polarimetric observations confirmed theoretical predictions, according to which X-ray radiation from magnetar sources is highly polarized, up to ≈80%, the highest value detected so far. This provides an independent confirmation that magnetars are indeed endowed with a super-strong magnetic field and that the twisted magnetosphere scenario is the most likely explanation for their soft X-ray emission. Polarization measurements allowed us to probe the physical conditions of the star’s outermost layers, showing that the cooler surface regions are in a condensed state, with no atmosphere on top. Although no smoking-gun of vacuum QED effects was found, the phase-dependent behavior of the polarization angle strongly hints that vacuum birefringence is indeed at work in magnetar magnetospheres.
Spin Evolution of Neutron Stars
Authors: Abolmasov Pavel , Biryukov Anton , Popov Sergei B.
Published: February 2024

In this paper we review the basics of magneto-rotational properties of neutron stars focusing on spin-up/spin-down behavior at different evolutionary stages. The main goal is to provide equations for the spin frequency changes in various regimes (radio pulsar, propeller, accretor, etc.). Since presently the spin behavior of neutron stars at all stages remains a subject of many uncertainties, we review different suggestions made over the years in the literature.
Global Rayleigh Wave Attenuation and Group Velocity from International Seismological Centre Data
Authors: Hearn Thomas Martin
Published: February 2024

This paper presents a study of global Rayleigh wave attenuation and group velocity at a period of around 20 s using data from the International Seismological Centre (ISC) bulletin. Rayleigh waves at this period are sensitive to the crustal structure beneath continents and the uppermost mantle beneath oceans. Tomographic imaging reveals strong continental-ocean contrasts due to this. Oceanic group velocities are high but vary with seafloor depth, while oceanic attenuation shows mid-ocean ridges. Subduction zone regions display high attenuation but little velocity reduction, indicating scattering attenuation. Low attenuation regions are associated with the Earth’s major cratonic regions, but there are no associated velocity changes. This implies that intrinsic attenuation is low and scattering dominates. Cratonic crustal scatterers have been annealed. A new surface wave magnitude scale is constructed that is valid from near-source to near-antipode distances.
Remotely Sensed and Field Data for Geomorphological Analysis of Water Springs: A Case Study of Ain Maarrouf
Authors: Muzirafuti Anselme
Published: February 2024

Tabular Middle Atlas of Morocco holds the main water reservoir that serves many cities across Morocco. Dolomite and limestone are the most dominant geologic formations in this region in which water resources are contained. The recent studies conducted to evaluate the quality of this water suggest that it is very vulnerable to pollutants resulting from both anthropogenic and natural phenomenon. High and very high-resolution satellite imagery have been used in an attempt to gain a better understanding of this karstic system and suggest a strategy for its protection in order to reduce the impact of these phenomenon. Based on the surface reflectance of land cover benchmarks, the karstic system has been horizontally delineated, as well as regions with intense human activities. Using band combination in the portion of the infrared, shortwave infrared, and visible parts of the electromagnetic spectrum, we identified bare lands which have been interpreted as carbonate rocks, clay minerals, uncultivated fields, basalts rocks, and built-up areas. Other classes such as water and vegetation have been identified. Carbonate rocks have been identified as areas with a high rate of water infiltration through their fracture system. Using a Sobel operator filter, these fractures have been mapped and their results have revealed new and existing faults in two major fracture directions, NE-SW and NW-SE, where NE-SW is the preferable pathway for surface water infiltration towards the groundwater reservoir, while the NW-SE direction drains groundwater from the Cause to the basin of Saiss. Over time, the infiltration of surface water through fractures has contributed to a gradual erosion of the carbonate rocks, which in turn developed karst landforms. This karst system is vulnerable due to the flow of pollutants in areas with shallow sinkholes. Using GDEM imagery, we extracted karst depressions, and their analysis shows that they are distributed along the fracture system and many of them were located on curvilinear or linear axes along the NE-SW fracture direction. We found also dolines scattered in areas with a high intensity of fractures. This distribution has been validated by both on-the-ground measurements and very high-resolution satellite images, and depressions of different forms and shapes dominated by dolines, poljes, lapiez, and avens have been identified. We also found many water springs with a highly important water output, such as the Ain Maarrouf water spring. The aim of this study is to enhance the understanding of the hydrogeological system of TMA, to improve the existence of the fracture database in the Cause of Agourai, and to establish a new morpho-structural picture of the Ain Maarrouf water spring.
Exploring the Use of Mobile Health for the Rehabilitation of Long COVID Patients: A Scoping Review
Authors: Daniels Kim , Mourad Joanna , Bonnechère Bruno
Published: February 2024

The COVID-19 pandemic has led to a substantial revolution in the incorporation of digital solutions in healthcare. This systematic review investigates the enduring physical and psychological consequences individuals experience up to two years post-recovery. Additionally, it focuses on examining the influence of mHealth interventions on these effects. Significantly, 41.7% of survivors experience lingering symptoms that have not been addressed, while 14.1% encounter difficulties in returning to work. The presence of anxiety, compromised respiratory functioning, and persistent symptoms highlight the immediate requirement for specific therapies. Telehealth, particularly telerehabilitation, presents itself as a possible way to address these difficulties. The study thoroughly examines 10 studies encompassing 749 COVID-19 patients, investigating the efficacy of telerehabilitation therapies in addressing various health markers. Telerehabilitation-based breathing exercises yield substantial enhancements in functional performance, dyspnea, and overall well-being. The results emphasize the potential of telerehabilitation to have a favorable effect on patient outcomes; however, more research is needed to strengthen the existing evidence base, as one of the most important limitations is the limited number of trials and the evaluation of varied therapies. This analysis highlights the significance of digital solutions in post-COVID care and calls for ongoing research to improve the comprehension and implementation of telehealth interventions in a swiftly changing healthcare environment.
Investigating Eating Habits of Children Aged between 6 Months and 3 Years in the Provinces of Modena and Reggio Emilia: Is Our Kids’ Diet Sustainable for Their and the Planet’s Health?
Authors: Palandri Lucia , Rocca Laura , Scasserra Maria Rosaria , Vigezzi Giacomo Pietro , Odone Anna , Iughetti Lorenzo , Lucaccioni Laura , Righi Elena
Published: February 2024

A healthy and balanced diet is crucial for children’s well-being and aids in preventing diet-related illnesses. Furthermore, unhealthy dietary habits indirectly impact children’s health, as the food industry stands as one of the primary drivers of climate change. Evidence shows the Mediterranean diet is sustainable for both children’s and the planet’s health. The aim of this cross-sectional study was to evaluate the eating habits of children aged between 6 months and 3 years, in the province of Modena and Reggio Emilia, in Italy, along with their adherence to the guidelines for a healthy diet, and examine the role of pediatricians in promoting knowledge about nutrition and sustainability. In our sample (218 children), most children exceeded the recommended meat and cheese intake, while consuming insufficient amounts of vegetables, fruit, and legumes. Vegetable and fruit consumption declined with the increase in age category while eating sweets, soft drinks, and processed food increased. Incorporating school meals’ data into this analysis, we observed a modification in dietary compliance, characterized by an increase in meat and cheese consumption, alongside improvements in the intake of vegetables, fruits, fish, eggs, and legumes. This study suggests that supporting an integrated approach that combines social and educational initiatives is crucial. Future research should prioritize fostering sustainable eating habits within communities to facilitate dietary habits’ transformation and encourage healthier lifestyles.
Cerebrovascular Disease Hospitalization Rates in End-Stage Kidney Disease Patients with Kidney Transplant and Peripheral Vascular Disease: Analysis Using the National Inpatient Sample (2005–2019)
Authors: Canova Tyler John , Issa Rochell , Baxter Patrick , Thomas Ian , Eltahawy Ehab , Ekwenna Obi
Published: February 2024

Individuals with end-stage kidney disease (ESKD) face higher cerebrovascular risk. Yet, the impact of peripheral vascular disease (PVD) and kidney transplantation (KTx) on hospitalization rates for cerebral infarction and hemorrhage remains underexplored. Analyzing 2,713,194 ESKD hospitalizations (2005–2019) using the National Inpatient Sample, we investigated hospitalization rates for ischemic and hemorrhagic cerebrovascular diseases concerning ESKD, PVD, KTx, or their combinations. Patients hospitalized with cerebral infarction due to thrombosis/embolism/occlusion (CITO) or artery occlusion resulting in cerebral ischemia (AOSI) had higher rates of comorbid ESKD and PVD (4.17% and 7.29%, respectively) versus non-CITO or AOSI hospitalizations (2.34%, p < 0.001; 2.29%, p < 0.001). Conversely, patients hospitalized with nontraumatic intracranial hemorrhage (NIH) had significantly lower rates of ESKD and PVD (1.64%) compared to non-NIH hospitalizations (2.34%, p < 0.001). Furthermore, hospitalizations for CITO or AOSI exhibited higher rates of KTx and PVD (0.17%, 0.09%, respectively) compared to non-CITO or AOSI hospitalizations (0.05%, p = 0.033; 0.05%, p = 0.002). Patients hospitalized with NIH showed similar rates of KTx and PVD (0.04%) versus non-NIH hospitalizations (0.05%, p = 0.34). This nationwide analysis reveals that PVD in ESKD patients is associated with increased hospitalization rates with cerebral ischemic events and reduced NIH events. Among KTx recipients, PVD correlated with increased hospitalizations for ischemic events, without affecting NIH. This highlights management concerns for patients with KTx and PVD.
Fatigue among Greek Parents of Children with Autistic Spectrum Disorder: The Roles of Spirituality and Social Support
Authors: Halki Eugenia , Kapiri Maria , Plakas Sotirios , Tsiou Chrysoula , Govina Ourania , Galanis Petros , Alikari Victoria
Published: February 2024

The high demands of caring for and raising a child with autism spectrum disorder on a daily basis may lead parents to physical and mental fatigue. This study aimed to assess the effect of social support and spirituality on the fatigue of parents with children with autistic spectrum disorder. A cross-sectional study with a convenience sample was conducted in Schools of Special Education in Attica (Greece). The sample consisted of 123 parents who completed The Fatigue Assessment Scale (FAS), the Multidimensional Scale of Perceived Social Support (MSPSS), and the Functional Assessment of Chronic Illness Therapy Spiritual Well-Being Scale (FACIT Sp-12) to measure the levels of fatigue, social support, and spirituality, respectively. The Pearson correlation coefficient was used to investigate the relationship between the quantitative variables. To study the effect of social support and spirituality on fatigue, multivariable linear regression was applied. The mean age was 47.3 years old, 81.3% were women, and 38.9% stated “Close/Very close faith toward God”. Higher levels of total MSPSS and FACIT Sp-12 were associated with lower total FAS (r = −0.50, p < 0.001 and r = −0.49, p < 0.001, respectively). Social support and spirituality were significant predictors of fatigue.
Gender, Socioeconomic Status, Race, and Ethnic Disparities in Bystander Cardiopulmonary Resuscitation and Education—A Scoping Review
Authors: Blewer Audrey L. , Bigham Blair L. , Kaplan Samantha , Del Rios Marina , Leary Marion
Published: February 2024

Background: Social determinants are associated with survival from out-of-hospital sudden cardiac arrest (SCA). Because prompt delivery of bystander CPR (B-CPR) doubles survival and B-CPR rates are low, we sought to assess whether gender, socioeconomic status (SES), race, and ethnicity are associated with lower rates of B-CPR and CPR training. Methods: This scoping review was conducted as part of the continuous evidence evaluation process for the 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care as part of the Resuscitation Education Science section. We searched PubMed and excluded citations that were abstracts only, letters or editorials, and pediatric studies. Results: We reviewed 762 manuscripts and identified 24 as relevant; 4 explored gender disparities; 12 explored SES; 11 explored race and ethnicity; and 3 had overlapping themes, all of which examined B-CPR or CPR training. Females were less likely to receive B-CPR than males in public locations. Observed gender disparities in B-CPR may be associated with individuals fearing accusations of inappropriate touching or injuring female victims. Studies demonstrated that low-SES neighborhoods were associated with lower rates of B-CPR and CPR training. In the US, predominantly Black and Hispanic neighborhoods were associated with lower rates of B-CPR and CPR training. Language barriers were associated with lack of CPR training. Conclusion: Gender, SES, race, and ethnicity impact receiving B-CPR and obtaining CPR training. The impact of this is that these populations are less likely to receive B-CPR, which decreases their odds of surviving SCA. These health disparities must be addressed. Our work can inform future research, education, and public health initiatives to promote equity in B-CPR knowledge and provision. As an immediate next step, organizations that develop and deliver CPR curricula to potential bystanders should engage affected communities to determine how best to improve training and delivery of B-CPR.
Fostering Pre-Professionals and Learning Experiences in End-of-Life Care Contexts: Music Therapy Internship Supervision
Authors: Clements-Cortés Amy , Klinck Sara
Published: February 2024

Certified music therapists use music within therapeutic relationships to address human needs, health, and well-being with a variety of populations. Palliative care and music therapy are holistic and diverse fields, adapting to unique issues within end-of-life contexts. Palliative care music therapy has been formally practiced since the late 1970s and affords a variety of benefits, including pain and anxiety reduction, enhancement of quality of life, emotional expression, and relationship completion. The training of music therapists varies around the globe, but clinical supervisors play a key role in skill acquisition. Clinical supervisors support pre-professionals as they realize the application of their training, foundational competencies, and authentic therapeutic approaches in end-of-life care, while navigating the challenges and rewards of this work. This article is a narrative review which offers background information on palliative care music therapy, and reports the authors’ viewpoints and reflections on supervision strategies and models employed with music therapy interns in palliative care settings based on their experiences. Approaches are shared on supporting pre-professionals as they begin working in palliative care contexts, as well as implications for supervision practices.
Perceptions of Clinical Adverse Event Reporting by Nurses and Midwives
Authors: Majda Anna , Majkut Michalina , Wróbel Aldona , Kurowska Anna , Wojcieszek Agata , Kołodziej Kinga , Bodys-Cupak Iwona , Rudek Joanna , Barzykowski Krystian
Published: February 2024

The level of safety in healthcare units is mainly characterized by the occurrence of medical adverse events. The aim of the study was to present the experiences of reporting clinical adverse events and the perceptions of nurses working in internal medicine wards, surgical wards and midwives on these issues. The cross-sectional survey was conducted from October 2022 to April 2023. The study used the Author’s Survey Questionnaire and sampling by assessment was applied. The study included nurses working in internal medicine wards and surgical wards as well as midwives at nine hospitals in a large provincial city in Poland, amounting to 745 participants. A one-way analysis of variance ANOVA and a post-hoc test (Fisher’s NIR) were used. The significance level (p) did not exceed 0.05. Nurses working in surgical wards, internal medicine wards and midwives thought that clinical adverse events should be reported, and perceived this as an important and useful activity in ensuring patient safety. The most common adverse events reported by respondents were falls F(2.742) = 52.07; p = 0.001, bedsores F(2.742) = 19.62; p = 0.001, patient disappearances F(2.742) = 3.98; p = 0.019, and hospital-acquired infections F(2.742) = 3.88; p = 0.021. The most frequently selected factors influencing the abandonment of adverse event reporting were excessively complex paperwork, no or little harm to the patient or a fear of the negative consequences. The study suggests that an important way to overcome the barriers to nurses and midwives reporting adverse events would be to create a supportive atmosphere in which they could report errors and the reasons for them honestly and without fear, and to improve the way adverse events are reported at the personal and institutional levels.
Adaptive Shooting Disciplines: A Scoping Review of the Literature with Bibliometric Analysis
Authors: Puce Luca , Biz Carlo , Ceylan Halil Ibrahim , Bragazzi Nicola Luigi , Formica Matteo , Trabelsi Khaled , Szarpak Łukasz , Trompetto Carlo , Rossin Alessandro , Lanciano Nicola Antonio , Ruggieri Pietro
Published: February 2024

Para-archery and para-shooting, two very popular adaptive shooting disciplines that have earned their place as major official events in the Paralympic Games, share some similarities, as well as distinctive features in terms of rules, physiological requirements, and equipment used. The International Paralympic Committee has a clear responsibility to ensure that all sports within its jurisdiction, including adaptive shooting, can achieve excellence in their respective fields. To achieve this, the conduct of well-designed studies and rigorous research is essential. Although some research has been conducted in this area, a comprehensive and systematic evaluation is still needed. Therefore, the present study aims to provide a thorough review and synthesis of existing research on adaptive shooting disciplines, identify strengths and gaps, and suggest future directions. Arksey and O’Malley’s methodology is leveraged and enhanced with bibliometric and policy analyses to review literature on adaptive shooting. Databases like PubMed/MEDLINE, Scopus, Web of Science, OvidSP, and EMBASE were searched, focusing on studies in adaptive shooting disciplines and analysing these findings through a blend of thematic and statistical methods. Twenty-four studies totalling 483 para-athletes (299 para-shooters and 184 para-archers) are included in this scoping review, focusing on a range of aspects, including physiological responses (n = 9), research design and measurement methods for evidence-based classification (n = 6), biopsychosocial aspects (n = 3), development of new methods and technologies (n = 4), kinematic and biomechanical assessment (n = 1), and epidemiology of injuries (n = 1). Seven articles focused exclusively on para-archery, thirteen exclusively on para-shooting, and four on both para-archery and para-shooting. In conclusion, the available literature on adaptive shooting disciplines is still very limited, especially regarding para-archery compared to para-shooting. This highlights the need for further research in many key areas to ensure a better understanding of the different disciplines and to provide appropriate support for para-athletes. Future research in para-archery and para-shooting should focus on technological innovations, biomechanical studies, and psychological support to enhance athlete performance and accessibility. Addressing the imbalance between the two disciplines, along with injury prevention and global participation, can drive the sports towards greater inclusivity and equity for para-athletes worldwide.
3D WebGIS for Ephemeral Architecture Documentation and Studies in the Humanities
Authors: Spreafico Alessandra , Chiabrando Filiberto
Published: February 2024

The documentation and visualization of ephemeral CH, especially for World’s Fairs architecture, remains a neglected endeavor on the global scale. While digital products like 3D models find extensive application in CH, the use of a WebGIS has scarcely been explored in this domain. When a WebGIS is used for CH, it serves to communicate the output of research, not as a tool to support the development of the research itself. Moreover, aspects like procedural development for the creation of a WebGIS platform, its upgrading, and its long-term preservation are key factors for the maintenance of the digital tool, but they have scarcely been considered in the literature. Through the Turin 1911 project, this paper defines a procedure for the creation of a WebGIS for ephemeral architectural documentation, showing how a WebGIS platform can be designed, implemented, tested, and maintained. The novelty of this study lies in the creation of a 2D/3D WebGIS based on a tailored spatial database; the WebGIS is coupled with a dedicated website for the constant updating of the research data documenting the Turin 1911 International Exposition. The discussion emphasizes the transformative role of a WebGIS in not only sharing information but also serving as a dynamic platform for conducting digital humanities studies in 3D environments.
The Disappearing Technology and Products of Traditional Tibetan Village Blacksmiths
Authors: Reedy Chandra L.
Published: February 2024

Tibetans have a long history of iron mining, smelting, and forging. For centuries, craftsmen in major cities and large iron production centers made high-quality swords and suits of armor, as well as decorative iron ritual objects for monasteries and the elites, but blacksmithing workshops in small villages have always produced and repaired everyday objects for agricultural and home use. Modern political changes, along with greater availability of industrial objects in local markets, have greatly reduced the rank of the village blacksmith. Ethnographic fieldwork reported here from two Tibetan Bön villages in the Aba Tibetan and Qiang Autonomous Prefecture, China (once part of traditional Amdo area of Tibet), highlights some of the threats to the continued existence of village blacksmiths. Both a part-time blacksmith in one village and a full-time blacksmith in another make only a marginal living from their work. Their descendants are unlikely to continue the business. Many of the village blacksmiths in the area have already stopped production and closed their workshops. It is likely that the village blacksmith tradition might soon disappear altogether in this region of the world without support. Preservation of this tradition could benefit both cultural and environmental sustainability goals.
Characterization of Changes in Active Ingredients and Mining of Key Metabolites in Bletilla striata under Shading and Drought Stresses
Authors: Yin Ruoyong , Chen Leiru , Deng Pengfei , Cao Xiaoqing , Xu Xiaoniu
Published: February 2024

Shading and drought are considered crucial abiotic stress factors that limit the normal growth of plants. Under natural conditions, the quality of Bletilla striata pseudobulbs (BP), a Chinese traditional medicinal crop, is often affected by the dual stresses of shading and drought. However, the relationship and mechanism of the interaction between the two stress factors in B. striata remain unclear. In this study, we examined the changes in photosynthetic properties and active ingredients of B. striata under shading (L), drought (W), and shading-drought dual stresses (LW). We aimed to explore the metabolite mechanism that led to these changes using GC-MS-based non-targeted metabolomics techniques. The results indicated a significant reduction in the polysaccharide content of BP under W and LW treatments compared to the control (CK). The total phenol content was significantly reduced under L treatment, while the total flavonoid content did not change significantly under the three stresses. The significant increase in militarine content under all three stresses implies that B. striata may modulate its biosynthesis in response to different environmental stresses. Transpiration rate and stomatal conductance were reduced, amino acid expression was up-regulated, and carbohydrate expression was down-regulated in B. striata under L treatment. The net photosynthesis rate, stomatal conductance, and transpiration rate exhibited significant reductions, and the tuber metabolic disorder marker Homocysteine increased and organic acid content as well under W treatment. The net photosynthetic rate, transpiration rate, stomatal conductance, and water use efficiency of B. striata were further reduced under LW compared with single stress, which is in agreement with the “trade-off theory”. Pseudobulb metabolite changes, in combination with the results of the two single stresses, showed an up-regulation of amino acids and disaccharide compounds and a down-regulation of monosaccharide compounds. A support vector machine model (SVM) was used to screen 10 marker metabolites and accurately predict the changes in active ingredient content through an artificial neural network model (ANN). The results suggest that an appropriate stress environment can enhance the content of the target active ingredients based on cultivation goals.
Temporary Immersion System as an Innovative Approach for In Vitro Propagation of Sorbus domestica L.
Authors: Gianguzzi Valeria , Sottile Francesco
Published: February 2024

The genus Sorbus has maintained an extremely relevant role over time from a landscape and environmental perspective in many countries in the Mediterranean and Central Europe. Based on the requirements coming from the environmental policies provided in the European strategy Next Generation EU, Sorbus has been considered a valuable species to be introduced in urban and peri-urban areas. The purpose of this study was to propagate four Sorbus accessions selected in the Sicilian territory, Southern Italy, using the liquid substrate in temporary immersion bioreactors Plantform™. The results obtained showed that the presence of 1 mg L−1 mT in the substrate in combination with IBA 0.05 mg L−1 produced a significant number of shoots (4.7) and a greater length (2.2 cm). Among the accessions, there were statistically significant differences; the accession SN2 and SN1 produced more shoots (respectively, 4.0 and 3.6), and a greater length of the shoots was observed in the selections SN4 and SN3 (respectively, 2.4 cm and 2.3 cm). The relative growth rate (RGR) was significantly influenced by the presence of the culture substrate of the combination of cytokines and auxin; SN4 selection showed the best RGR results of 8.3 mg−1 d−1. The use of the bioreactor Plantform™ in Sorbus domestica L. has favored a better development of plants obtained in vitro, demonstrating that this system is a valid alternative for the micropropagation of Sorbus.
Optimization of an Efficient Direct Shoot Induction System and Histological Evaluation of Shoot Formation in Cucurbita maxima Duch
Authors: Song Huijuan , Chen Zhongquan , Yan Jiali , Jiang Hong , Dai Sihui , Yang Hongbo , Sun Longjun , Sun Xiaowu
Published: February 2024

Improving plant regeneration ability and shortening regeneration time can promote the development of genetic transformation breeding technology for horticultural crops. We optimized several culture conditions, including explant type, mother plant genotype, and medium, to improve shoot formation in winter squash (Cucurbita maxima Duch.). Histological analysis of the occurrence of shoots was also carried out. The results indicate that cotyledon was the most suitable explant for inducing the shoot regeneration of winter squash. We found that ‘Jin-li’ had a shorter shoot induction time and a higher average number of shoots. The highest induction rate of 95.23% among the five lines. The average shoot induction rate of five lines was the highest (84.85%) on Murashige and Skoog (MS) medium supplemented with 2.0 mg/L 6-benzylaminopurine (6-BA) and 0.2 mg/L indole-3-acetic acid (IAA). We also found that there was an interaction between genotypes and induction media, and their interaction had a greater impact on the shoot induction rate than individual effects. Histological observation revealed that the induced shoots of winter squash cotyledons originated from subepidermal cells. We also found that the optimal medium for de novo root regeneration was 1/2 MS. We acclimatized and cultivated regenerated plants and harvested their fruits, which maintained the characteristics of mother plants. These findings lay an important foundation for further research on direct shoot regeneration and accelerate its application in winter squash genetic transformation.