bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Efficacy Upon Infection in Sheep with Rift Valley Fever Virus ZH548-rA2, a Triple Mutant Rescued Virus
Authors: Moreno Sandra , Lorenzo Gema , López-Valiñas Álvaro , De la Losa Nuria , Alonso Celia , Charro Elena , Núñez José I. , Sánchez-Cordón Pedro J. , Borrego Belén , Brun Alejandro
Published: December 2023

The introduction of three single nucleotide mutations into the genome of the virulent RVFV ZH548 strain allows the rescue of a fully attenuated virus in mice (ZH548-rA2). These mutations are located in the viral genes encoding the RdRp and the non-structural protein NSs. This paper shows the results obtained after subcutaneous inoculation of ZH548-rA2 in adult sheep and subsequent challenge with the parental virus (ZH548-rC1). Inoculation with ZH548-rA2 virus caused no detectable clinical or pathological effect in sheep, whereas inoculation of the parental rC1 virus caused lesions compatible with viral infection characterized by the presence of scattered hepatic necrosis. Viral infection was confirmed by immunohistochemistry, with hepatocytes within the necrotic foci appearing as the main cells immunolabelled against viral antigen. Furthermore, inoculation of sheep with rA2 virus prevented the liver damage expected after rC1 virus inoculation, suggesting a protective efficacy in sheep which correlated with the induction of both humoral and cell mediated immune responses.
Comparative Analysis of COVID-19 Severity and Mortality Among Vaccinated and Unvaccinated Individuals During the Delta Variant Surge in a Tertiary Care Center
Authors: Hasani Fatemeh , Norouzi Zahra , Roshandel Gholamreza , Norouzi Alireza
Published: December 2023

Introduction: On March 11, 2020, the World Health Organization (WHO) declared Coronavirus disease 2019 (COVID-19) as a pandemic. The spread of the Delta variant of coronavirus started in June 2021 and accounted for the fifth peak of COVID-19 in Iran in July 2021. According to reports from other countries, vaccination protects against severe diseases caused by COVID-19, including the Delta variant. Studies have also shown that vaccination provides strong protection against SARS-CoV-2 infection, COVID-19-related hospitalization, and mortality. This retrospective cohort study was designed based on the medical care monitoring center (MCMC) database of Sayyad Shirazi Hospital.Methods: The following patient data were extracted for this study: demographic characteristics, signs and symptoms, ICU admission, need for aggressive oxygen therapy, including intubation, mortality, and vaccination status. Results: Being vaccinated was associated with a 4.14-fold increase in survival (adjusted OR=4.14; 95% CI: 2.22 to 7.69; P<0.01), and individuals in a younger age group demonstrated a 5.58-fold higher likelihood of surviving (adjusted OR=5.58; 95% CI: 4.25 to 8.14; P<0.01). The risk of severe COVID-19 was significantly lower in vaccinated individuals, showing a 3.12-fold decrease in risk (adjusted OR=3.12; 95% CI: 2.06 to 4.72; P<0.01), and in younger age groups, the risk exhibited a 3.28-fold decrease (adjusted OR=3.28; 95% CI: 2.66 to 4.04; P<0.01).Conclusion: The present results suggest that receiving at least one dose of COVID-19 vaccine had a significant relationship with decreased COVID-19 severity and mortality in vaccinated patients compared to unvaccinated patients.
Cladosporium - Insect Relationships
Authors: Nicoletti Rosario , Russo Elia , Becchimanzi Andrea
Published: December 2023

The range of interactions between Cladosporium, an ubiquitous fungal genus, and insects, a class including about 60% of the animal species, is extremely diverse. The broad case history of antagonism and mutualism connecting Cladosporium and insects is reviewed in this paper based on the examination of the available literature. Certain strains establish direct interactions with pest or beneficial insects, or indirectly influence them through their endophytic development in plants. Entomopathogenicity is often connected to the production of toxic secondary metabolites, although there is a case where these compounds have been reported to favor pollinators attraction, suggesting an important role in angiosperm reproduction. Other relationships include mycophagy, which on the other hand may reflect an ecological advantage for these extremely adaptable fungi using insects as carriers for spreading in the environment. Several Cladosporium species colonize insect structures, such as galleries of ambrosia beetles, leaf-rolls of attelabid weevils and galls formed by cecidomyid midges, playing a still uncertain symbiotic role. Finally, the occurrence of Cladosporium in the gut of several insect species has intriguing implications in pest management, also considering that some strains have proven to be able to degrade insecticides. These interactions especially deserve further investigation to understand the impact of these fungi on pest control measures and strategies to preserve beneficial insects.
Validation of a New Spectral-Domain Optical Coherence Tomog-Raphy-Based Biometer
Authors: Alió Jorge L. , José-Martínez Marina , Martínez-Abad Antonio , Rodríguez Alejandra E. , Versaci Francesco , Hjortdal Jesper , Murta Joaquim Neto , Plaza-Puche Ana B , Cantó-Cerdán Mario , Piñero David P.
Published: December 2023

The VEMoS AXL system is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT), which is considered the gold standard, for an agreement analysis. A biometric analysis was performed three consecutive times in 120 healthy eyes of 120 patients aged between 18 and 40 years with the SD-OCT system and afterwards a single measurement was obtained with the SS-OCT system. Within-subject standard deviations were 0.004 mm, 4.394 µm and 0.017 mm for axial length (AL), central corneal thickness (CCT), and anterior chamber depth (ACD) measures obtained with the SD-OCT biometer, re-spectively. The agreement between devices was good for AL (Limits of agreement, LoA: -0.04 to 0.03 mm) and CCT (LoA: -4.36 to 14.38 µm), whereas differences between devices were clinically relevant for ACD (LoA: 0.03 to 0.21 mm). In conclusion, the VEMoS AXL system provides consistent measures of anatomical parameters, being most of them interchangeable with those provided by the SS-OCT-based gold standard.
Natural Gas Sweetening via Membrane-Assisted Gas Absorption. Part 1: A Hollow-Fiber Unit with MDEA-Based Absorbent
Authors: Petukhov Anton , Atlaskin Artem , Smorodin Kirill , Atlaskina Mariia , Zarubin Dmitriy Mikhailovich , Tsivkovsky Nikita S. , Kryuchkov Sergey , Stepakova Anna , Vorotyntsev Andrey , Kazarina Olga , Suvorov Sergey , Stepanova Ekaterina , Vorotyntsev Ilya
Published: December 2023

The present study focuses on the development and optimization of a highly efficient unique hybrid technique — membrane-assisted gas absorption (MAGA) in designing the separation unit, which provides the improvement in mass-transfer of a target component during the natural gas processing in terms of sweetening stage. A novel design of membrane-assisted gas absorption cell is used to enhance the ratio between absorbent amount and membrane surface available for permeation. The performance tests were implemented on example of two gas mixtures separation: one is model ternary gas mixture and the second is quasi real natural gas, which includes number of hydrocarbons, nitrogen, acid impurities and xenon. For both cases, the MAGA unit demonstrated high acid gases removal efficiency, and high recovery of hydrocarbons. The ultimate efficiency of studied system was up to 96 and 61 % of removed acid gases with hydrocarbons losses up to 1 % at highest productivity. In this way, the residual sum of acid gases content may be lowered to 1 vol.% using the heat-free hybrid membrane-assisted gas absorption unit maintaining suitable recovery rate of methane, ethane, propane and n-butane. Nevertheless, the overall efficiency of the process may be enhanced using the specific absorption agents with aqueous amino alcohol solutions.
Targeting MutT homolog 1 (MTH1) for breast cancer suppression by a novel MTH1 inhibitor MA-24 with tumor-selective toxicity
Authors: Kang Nannan , Ma Jun , Hu Yuling , Di Rongrong , Wang Lei , Zhang Xuanling , Lai Yisheng , Liu Yu
Published: December 2023

Background: Breast cancer is a commonly diagnosed cancer worldwide. Human MutT homolog 1 (MTH1) is found to be elevated in breast tumors and cancer cells are addicted to MTH1 for sur-vival. Pharmacological inhibition of MTH1 may be potentially beneficial in the treatment of breast cancer.
Methods: MA-24 was screened by malachite green colorimetric assay from MTH1 inhibitors and the kinetic characteristics of MA-24 was assessed. Binding features of MA-24 with MTH1 was as-certained through molecular docking, and cytotoxic activity of MA-24 was validated in vitro and in vivo. Target engagement assays, comet assay and western blot confirmed that the intracellular target and mechanism of MA-24.
Results: MA-24 with potent antitumor bioactivity both in vitro and in vivo. MA-24 competitively inhibited the MTH1 and further induce DNA strand breaks, leading to increased apoptosis of cancer cells depending on upregulation of cleaved-caspase 3 – cleaved-PARP axis. Especially, MA-24 exhibited a powerful efficacy and safety in vivo (tumor growth inhibition rate: 61.8%).
Conclusions: MA-24 possesses a broad spectrum of breast cancer cytotoxicity and offered valuable insights for overcoming the challenges of chemotherapy-related toxicity, which holds great po-tential for further development MA-24 as an anti-cancer drug.
Investigating Misinformation about COVID-19 on YouTube using Topic Modeling, Sentiment Analysis, and Language Analysis
Authors: Thakur Nirmalya , Cui Shuqi , Knieling Victoria , Khanna Karam , Shao Mingchen
Published: December 2023

The work presented in this paper makes multiple scientific contributions with a specific focus on the analysis of misinformation about COVID-19 on YouTube. First, the results of topic modeling performed on the video descriptions of YouTube videos containing misinformation about COVID-19 revealed four distinct themes or focus areas - Promotion and Outreach Efforts, Treatment for COVID-19, Conspiracy Theories regarding COVID-19, and COVID-19 and Politics. Second, the results of topic-specific sentiment analysis revealed the sentiment associated with each of these themes. For the videos belonging to the theme of Promotion and Outreach Efforts, 45.8% were neutral, 39.8% were positive, and 14.4% were negative, for the videos belonging to the theme of Treatment for COVID-19, 38.113% were positive, 31.343% were neutral, and 30.544% were negative, for the videos belonging to the theme of Conspiracy Theories regarding COVID-19, 46.9% were positive, 31.0% were neutral, and 22.1% were negative, and for the videos belonging to the theme of COVID-19 and Politics, 35.70% were positive, 32.86% were negative, and 31.44% were negative. Third, topic-specific language analysis was performed to detect the various languages in which the video descriptions per topic were published on YouTube. This analysis revealed multiple novel insights. For instance, for all the themes, English and Spanish were the most widely used and second-most widely used languages, respectively. Fourth, the patterns of sharing these videos on other social media channels such as Facebook and Twitter were also investigated. The results revealed that videos containing video descriptions in English were shared the highest number of times on Facebook and Twitter. Finally, correlation analysis was performed by taking into account multiple characteristics of these videos. The results revealed that the correlation between the length of the video title and the number of Tweets as well as the correlation between the length of the video title and the number of Facebook posts was statistically significant.
Blockchain Based Information Retrieval System: A Survey
Authors: Kaleem Sidrah , Ashraf Humaira , Jhanjhi NZ
Published: December 2023

One of the most popular developments today that potentially address security issues with cloud computing is the use of blockchain. Blockchain is a decentralized data management platform that offers data integrity, security, and anonymity without the involvement of a third party. This work presents a comprehensive study of blockchain-based data storage system and their security concerns with their solutions to address these concerns. We provide a thorough overview of how blockchain is used in the cloud computing model to provide security services, and we examine the research trends of blockchain-related technologies in the current cloud computing models. As we examine, we also quickly look into how cloud computing may impact blockchain, particularly the performance enhancements that cloud computing may offer. This paper performs a review of the cutting-edge investigations of the blockchain-based system with a selfish-mining attack and the primary focus on IPFS. We also note their challenges, open issues, and future directions. The findings demonstrate that blockchain offers a productive platform in this area. However, one of the most significant problems that still need more research is security-related issues. The article offers a platform for future research and action as well.
Harnessing Multistability: A Novel Approach to Optical Logic Gate Construction Using Erbium-Doped Fiber Lasers
Authors: Bibi Safara , Echenausía-Monroy José Luis , Jaimes-Reátegui Rider , García-López Juan Hugo , Huerta-Cuellar Guillermo , Pisarchik Alexander N.
Published: December 2023

We present an innovative method harnessing multistability within a diode-pumped erbium-doped fiber laser to construct logic gates. Our approach involves manipulating the intensity of external noise to regulate the probability of transitioning among four concurrent attractors. In this manner, we facilitate the realization of OR, AND, NOT, and NOR logic operations, aligning with the coexisting period-1, period-3, period-4, and period-5 orbits. Employing detrended fluctuation analysis, we establish equilibrium in the probability distributions of these states. The obtained results denote a substantial advancement in the field of optical logic gate development, representing a pivotal stride toward the seamless integration of an all-optical logic gate within laser oscillator-based systems.
Health Promoting Properties and Applications of Nu-Trients and Bioactives of Watermelon and Its By-Products
Authors: Meghwar Parkash , Saeed Syed Muhammad Ghufran , Ullah Asad , Nikolakakis Emmanouil , Panagopoulou Eirini , Smaoui Slim , Tsoupras Alexandros
Published: December 2023

The increasing demand by consumers for popular healthy fruits, such as the watermelon (Citrullus lanatus), generate substantial bio-wastes, making it imperative to harness the value of these by-products. Watermelon has low-calorie content and several other nutritional benefits that make it suitable for weight management and heart-healthy diets. Within this article, the nutritional composition and bioactives of watermelon which are strongly linked to the prevention of cardiovascular disorders (CVD), cancer, and age-related conditions, will be thoroughly reviewed. In addition, the therapeutic potential effects of watermelon consumption, such as anti-inflammatory, cardio-protective and anti-cancer properties, are also examined, with emphasis to the importance of incorporating watermelon into regular diets for overall health improvement. Additionally, the study explores various applications of watermelon by-products in functional foods, contributing to meeting recommended daily nutrient allowances, as well as in other functional products like cosmetics, with health promoting properties. In conclusion, this comprehensive review underscores the role of watermelon and its by-products for the development of products that can contribute to the prevention of chronic diseases and promote overall well-being
Illustrative Case Series and Narrative Review of Intra-abdominal Abscesses:A Radiological Perspective.
Authors: Siriwardana Shirom Rajeev , Anjula Pramesha Dilhari
Published: December 2023

Abstract: Intra-abdominal abscesses (IAA) may commonly arise following complicated gastrointestinal tract infections and, on occasion, from infections within the urinary system. Many of these IAA are initiated as a consequence of post-surgical complications. These abscesses have a substantial risk of morbidity and mortality. As a result, it is crucial to diagnose and treat them promptly to minimise these adverse outcomes. Therefore, radiological modalities play a vital role in diagnosing, localising, and detecting associated complications of IAA, as sometimes other investigations could be less reliable and non-specific. Radiological modalities are pivotal in achieving an accurate diagnosis, localising the abscesses, and identifying associated complications. This is especially important since alternative investigative methods may be misleading in certain situations. Radiological techniques such as ultrasound scans (USS), contrast-enhanced computed tomography (CECT), and even magnetic resonance imaging (MRI) are immensely helpful in diagnosing these conditions. These imaging tools guide clinicians in determining the most appropriate patient management strategies. In this article, we compile a case series involving tubo-ovarian abscess, appendicular abscess, diverticular abscess and infected walled-off pancreatic necrosis, paying particular attention to radiological features in the diagnosis. Furthermore, we reviewed the existing literature to delineate characteristic radiological features related to the cases we discussed.
Assessment of protein-energy malnutrition severity in infants: pyruvate as a biochemical marker of low muscle mass
Authors:   Samara State Medical University, Samara, Russian Federation, Gorbacheva I.V. , Kuznetsova O.Y. ,   Samara State Medical University, Samara, Russian Federation, Gilmiarova F.N. ,   Samara State Medical University, Samara, Russian Federation, Pechkurov D.V. ,   Samara State Medical University, Samara, Russian Federation
Published: December 2023

Protein-energy malnutrition (PEM) is one of common health problems in infancy. Multiple causation of PEM, its cooccurrence with rickets, anemia, and infectious diseases, as well as high prevalence of PEM makes it a substantial challenge for medical and biological sciences. Objective. To identify significant diagnostic and prognostic biochemical criteria to assess PEM severity in children of the first year of life. Patients and methods. This study included 82 infants with PEM (41 boys and 41 girls) aged 1 to 12 months. Of them, 37 were full-term (44.2%), whereas 45 were preterm (55.8%). Clinical and anthropometric examination showed that 38 infants (46.3%) had grade I PEM; 30 infants (36.6%) had grade II PEM; 14 infants (17.1%) had grade III PEM. Cobas Integra 400рlus (Switzerland) was used to measure total protein and its fractions, transferrin, urea, creatinine, glucose, lactate, pyruvate, lactate/pyruvate index, triacylglycerols, ALT, AST, lactate dehydrogenase, and creatine kinase. Protein fractions were separated using electrophoresis with the Hydrasys2 Scan (France). Results. Serum level of pyruvate demonstrated the best correlation with body weight deficiency and PEM severity in infants. Key words: protein-energy malnutrition, infants, body weight deficiency, laboratory parameters, pyruvate
Complex thermo-manometry in the diagnosis of nasal breathing parameters in children with chronic adenoiditis
Authors:   M.F.Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation, Golubeva O.B. , Egorov V.I. ,   M.F.Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation, Garashchenko T.I. ,   The National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia, Moscow, Russian Federation, Vasilenko I.A. ,   M.F.Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation,   A.N.Kosygin Russian State University, Moscow, Russian Federation, Metelin V.B. ,   M.F.Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation,   A.N.Kosygin Russian State University, Moscow, Russian Federation
Published: December 2023

Chronic nasal congestion is an underestimated condition that has a significant impact on the patient's quality of life. Objective. Evaluation of the effectiveness of using of the domestic diagnostic technology of complex thermo- manometry of nasal airflow in children with chronic adenoiditis. Patients and methods. 152 children with a verified diagnosis of adenoiditis aged from 3 to 10 years were examined, the complex of diagnostic measures of which additionally included thermo-manometry of nasal breathing using the apparatus for diagnosing nasal breathing parameters. The protocols of recording the aerodynamics of the airflow in the vestibule of the nose using Hurst coefficients for temperature (kHT) and pressure (kHP) data were analyzed. Results. Statistically significant decrease in the value of kHT was found in patients with adenoiditis (by 19.2%, p = 0.0001) both in the general group and in the separation of patients by age: in the group of 3–6 years – by 19.2% (p = 0.0006), in the group of 7–10 years – by 17.7% (p = 0.0006). The decrease in kНТ values in children was associated with the presence of adenoid vegetations of the 2nd–3rd degree. Conclusion. The method makes it possible to simplify the diagnostic procedure by shortening the study time of parameters, provides the personalized assessment of the features of intra-nasal aerodynamics in real time in children. Key words: adenoiditis, nasal breathing, endonasal thermo-manometry
Post-COVID conditions in children
Authors:   Khimki Regional Hospital, Khimki, Russian Federation, Sabinina Т.S. , Muzyka А.D. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Shalbarova Т.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Melekhina Е.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Gorelov А.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: December 2023

Objective. To study the clinical and laboratory characteristics of post-COVID conditions in children. Patients and methods. A total of 78 children aged 10 months to 15 years with a history of COVID-19 were examined. The study group included 43 children with post-COVID syndrome, the comparison group – 35 patients without its symptoms. Results. Post-COVID conditions were recorded in 55% (43/78) of children, more frequently in girls – 58.1% (25) and 37.1% (13), p = 0.065. In the study group, children commonly had moderate COVID-19 – 10 (23.3%) and 5 (14.3%); in the comparison group, a mildly symptomatic course prevailed – 12 (34.3%) and 7 (16.3%), p = 0.161. Patient complaints in the study group were skin rashes in 34.9% (14), recurrent respiratory infections (RRIs) in 25.6% (11), subfebrile temperature in 20.9% (9), common symptoms in 16.3% (7), recurrent orofacial herpes in 18.6% (8), neutropenia in 11.6% (5); 3 patients had debut of arrhythmia and 3 had debut of epilepsy. Reactivation of herpesvirus infections after COVID-19 was registered in 22 (51.2%) children in the study group and in 9 (25.7%) in the comparison group, p = 0.022. Meglumine acridone acetate (Cycloferon®) was prescribed to 25 children with reactivated herpesvirus infections. After treatment, clinical improvement was achieved in 20 patients: 13 in the study group and 7 in the comparison group. Conclusion. Post-COVID conditions were detected in 55% of children and were more often manifested as skin rashes (34.9%), RRIs (25.6%), prolonged subfebrile temperature (20.9%), recurrent orofacial herpes (18.6%). Cycloferon® is effective in children with reactivation of herpesvirus infections in the post-COVID period. Key words: herpesvirus infections, children, meglumine acridone acetate, post-COVID conditions
Clinical and anamnestic features of the course of necrotizing enterocolitis in premature infants
Authors:   Siberian State Medical University, Tomsk, Russian Federation, Kim L.V. , Zhelev V.A. ,   Siberian State Medical University, Tomsk, Russian Federation, Slizovsky G.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Devald E.V. ,   I.D.Yevtushenko Regional Perinatal Center, Tomsk, Russian Federation
Published: December 2023

Objective. To study clinical, anamnestic and laboratory features and to determine risk factors for necrotizing enterocolitis (NEC) in premature infants. Patients and methods. A retrospective analysis of the medical records of 47 premature infants with very low and extremely low birth weight (VLBW/ELBW) and NEC was performed. Newborns were divided into an early-onset group (n = 22) and a lateonset group (n = 25). Groups were compared for perinatal status, clinical symptoms, laboratory findings, and clinical outcomes. As a control group, 50 children without NEC were selected. Risk factors for the development of NEC were determined using multivariate logistic regression analysis. Results. When comparing groups with early- and late-onset NEC, it was noted that in the group with early onset, the number of children with the Apgar score at 1 minute ≤3, stage 3 NEC, surgical treatment, intraventricular hemorrhage ≥ grade 3, apnea and fever or hypothermia was higher. Multivariate logistic regression analysis showed that impaired enteral nutrition tolerance, early sepsis, severe anemia, and hemodynamically significant patent ductus arteriosus were independent risk factors for earlyonset NEC in VLBW/ELBW preterm infants (p < 0.05). Conclusion. Neonates with enteral intolerance, early sepsis, severe anemia, or hemodynamically significant patent ductus arteriosus are at higher risk of developing NEC. Key words: necrotizing enterocolitis, early diagnosis, premature, newborns
Acute mesenteric lymphadenitis in children
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin A.I. ,   Belgorod State University, Belgorod, Russian Federation, Danilenko S.O. ,   Novosibirsk State University, Novosibirsk, Russian Federation, Denisov M.Yu. ,   Novosibirsk State University, Novosibirsk, Russian Federation, Shrainer E.V. ,   Novosibirsk State University, Novosibirsk, Russian Federation,   Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Kovtun T.A. ,   Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
Published: December 2023

The review is devoted to the problem of nonspecific mesenteric lymphadenitis (NML) in children caused by viral infections. The children's immune system actively interacts with pathogens, which can lead to the development of NML. Diagnosis of this condition is a challenge for the doctor, since its symptoms may coincide with other diseases of the abdominal cavity, complicates the determination of an accurate diagnosis and treatment. The COVID-19 pandemic has expanded the understanding of the mechanisms of NML development, but has not provided sufficient information about treatment. Some patients continue to be subjected to unnecessary invasive examination methods, and the use of ultrasound for differential diagnosis of acute abdominal syndrome in children remains an urgent problem. We have limited number of studies devoted to the treatment of NML in children, all the data presented are ambiguous and need to be improved. The purpose of the review is to analyze the available data for deeper understanding of this condition. Key words: acute mesadenitis, children, viral infections, abdominal pain
influências do engajamento na percepção de sistemas de gestão da qualidade na indústria de óleo e gás
Authors: Gomes da Silva Neves Nathalia , Medeiros Ribeiro Salles Denise
Published: December 2023

As empresas estão cada vez mais inseridas em um sistema de melhoria contínua, dando importância à necessidade de garantir aos seus clientes que os produtos e serviços ofertados tenham qualidade e, para tanto, buscam implementar mudanças significativas que o comprovem. A fim de possuir um maior controle organizacional, atrair novos consumidores e melhorar o seu desempenho e relacionamento com os fornecedores, diariamente as organizações têm investido no Sistema de Gestão de Qualidade. O presente estudo tem por objetivo verificar a influência do engajamento de pessoas na percepção de sistemas de gestão organizacionais, de acordo com o modelo Job-Demands Resources em empresas do segmento de óleo e gás que optaram por obter certificações dos seus sistemas de gestão pelo API (American Petroleum Institute). Na pesquisa foi utilizada a triangulação de técnicas de obtenção e análise de dados a fim de prover uma visão atenta aos aspectos subjetivos, focando na observação do envolvimento de gestores e colaboradores, na adoção de boas práticas e em fatores críticos de sucesso na implementação do Sistema de Gestão de Qualidade (SGQ). A pesquisa de campo, realizada em três empresas situadas em Macaé, estado do Rio de Janeiro, mostrou que, durante a implementação do SGQ, ocorreram alguns problemas, tais como o baixo envolvimento dos colaboradores, a necessidade de suporte e feedbacks constantes através de comunicações contínuas, bem como, por parte dos colaboradores, dificuldade de concentração e priorização das atividades, além da necessidade de formação e de maior quantitativo de mão de obra; houve, ainda, relatos de resistência às mudanças. No entanto, foram verificados impactos positivos da implantação da certificação e do engajamento dos colaboradores em todas as organizações entrevistadas, contribuindo para uma ampla melhoria interna, para o aumento da satisfação dos clientes, percepção de boa reputação, eficiente relacionamento com fornecedores, maior controle dos processos e produtividade. Com a análise do engajamento e consequências das certificações, o presente trabalho visa contribuir para a compreensão da relevância desses processos, permitindo uma visão mais ampla no ramo de petróleo e gás acerca da percepção de sistemas de gestão organizacionais.
Palavras-chave: Engajamento; Percepção; Sistemas de Gestão.
EVALUATION OF USER EXPERIENCE AS A BASIS FOR THE DEVELOPMENT OF INNOVATIVE PEDAGOGY ON THE BIM E-LEARNING PLATFORM
Authors:   Lodz University of Technology Institute of Architecture and Urban Planning, Poland, Kępczyńska-Walczak Anetta
Published: December 2023

This article presents the outcomes of the testing of the Clash Detection Module, which is part of an e-learning platform designed for BIM self-education of students in the AEC sector. This platform was created as part of the implementation of the BIMaHEAD EU-funded Project in 2021-2023. The author points to the validity of the chosen direction of developing new forms of learning addressed to the needs of Generation Z. This was confirmed by the user experience survey. The feedback collected from the students helped to develop solutions customised to the learners needs.
PLACE MAKING OR PLACE TAKING IN THE CONTEXT OF ARCHITECTURAL DESIGN EDUCATION
Authors:   West Pomeranian University of Technology in Szczecin Faculty of Architecture, Poland, Świątek Leszek
Published: December 2023

By succumbing to the propaganda that design is about creating the 'new', we escape from reflecting on the moment of discovery in a living ecosystem. Reflective practice allows us to understand the continuity of development and provides an opportunity to engage speculative users in the acceptance of a symbiotically designed space, as opposed to revolutionary acts of uncritical design. The combination of theory and practice on the basis of projects carried out in the first years of study leads to Poiesis, as well as a sense of responsibility for lost natural capital, progressive gentrification or the disappearance of local activity.
UNIVERSITY–MUNICIPALITY–BUSINESS (TRIPLE HELIX) COOPERATION MODEL IN PRACTICE – ECOLOGICAL DISTRICT OF INNOVATION AND TECHNOLOGY IN POZNAN (EDIT POZNAŃ)
Authors:   Faculty of Architecture, Poznan University of Technology Institute of Interior Design and Industrial Design, Poland, Bonenberg Agata , Angoneze-Grela Ewa ,   Faculty of Architecture, Poznan University of Technology Institute of Interior Design and Industrial Design, Poland
Published: December 2023

The article serves as a progress report on the activities of the international project entitled "Ecological Cooperative of Innovation and Technology" (EDIT Poznań). The project originated from the initiative of the Faculty of Architecture at Poznań University of Technology and represents a response to the United Nations' call for achieving sustainable development goals through multilateral partnerships. The article highlights the achievements of the scientific research team in the project's inaugural year and introduces the practical application of the Triple Helix model. This conceptual framework advocates for collaboration among three primary” actors”: the academic, public, and private sectors. Using EDIT Poznań as a case study, the benefits and challenges facing stakeholders. Additionally, the role of architects and urban planners in designing sustainable cities of the future is emphasized.
ANALYSIS OF DEVELOPMENT TRENDS OF CITTASLOW NETWORK CITIES IN POLAND IN THE YEARS 2006-2019
Authors:   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie, Wydział Architektury, Gazińska Olga , Czyńska Klara ,   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie, Wydział Architektury, Rubinowicz Paweł ,   Zachodniopomorski Uniwersytet Technologiczny w Szczecinie, Wydział Architektury
Published: December 2023

The article presents a study of Polish cities, members of the cittaslow network, before the COVID-19 pandemic. The analysis covered twenty-nine cities that belonged to the network before 2019. The research is divided into three stages: the first one focuses on the analysis of strategic and planning documents at the municipal, provincial, and national levels; the second one examines investments by the cities and determines their relation to the cittaslow idea to highlight directions of development; whereas the third stage analyses statistical data to determine whether the cittaslow cities in Poland show an upward growth trend based on selected indicators. The analyses aim to assess whether and to what extent the idea of cittaslow is an important factor in the development of the cities.
RAINWATER RETENTION IN A HOUSING ESTATES. ANALYSIS AND IMPLEMENTATION POSSIBILITIES BGI – A CASE STUDY OF LUBLIN
Authors:   Faculty of Civil Engineering and Architecture Lublin University of Technology, Poland, Kozak Małgorzata , Hołownia Damian ,   Faculty of Civil Engineering and Architecture Lublin University of Technology, Poland
Published: December 2023

The article examines the architecture from the times of the Polish People's Republic (PRL) and compares it with contemporary multi-family residential developments in terms of water retention. Neglecting this aspect in multi-family housing estates and the paving of surfaces in new housing developments pose a problem. A case study from Lublin was used to identify factors influencing the implementation of blue-green infrastructure (BGI). Using SCALGO Live software, the accumulation areas of rainwater were analyzed and evaluated for BGI implementation. The results indicate that a direct interpretation of computer simulations as BGI implementation sites can be erroneous. The identification of locations for this solutions requires consideration of many other factors.
RESEARCH INTO PROPORTIONS OF A HISTORICAL URBAN DEVELOPMENT – EXAMPLE OF THE NEW CITY DISTRICT OF SZCZECIN
Authors:   West Pomeranian University of Technology Szczecin, Poland Faculty of Architecture, Kozłowska Izabela , Rek-Lipczyńska Agnieszka ,   West Pomeranian University of Technology Szczecin, Poland Faculty of Architecture
Published: December 2023

Proportion and mathematical ratio, as elements of beauty, have been used in architecture and urban planning since ancient times. This article presents a case study of this phenomenon in the form of mathematical analysis of spatial parameters in the district of Nowe Miasto in Szczecin (1845). The analysis demonstrates the absence of the use of geometrical proportion principles, while the principle of ratios was applied. The urban composition of New Town features urban elements shaped in the Baroque era, such as wide promenades connected to squares. However there has been a "loosening" of the rigorous geometry and symmetry typical of the Baroque era.
LOCUS THEOLOGIAE IN ARCHITECTURE AND SACRED ART – A CASE STUDY
Authors:   Bialystok University of Technology, Faculty of Architecture, Poland, Kimsza Radoslaw
Published: December 2023

The article, in the theological and philosophical key, shows the Christian understanding of beauty and its place in the broadly understood sacred art. The author points to a specific evolution of beauty, which from the Renaissance to modern times lost its original mysticism of beauty in favor of its individualistic interpretations, closing the need to find divine-human unity in sacred art. This is expressed in the liturgy and the eternal connection with it of the arts, both structural and expressive. Looking for patterns reaching the essence of beauty in sacred arts, the author brings out two Italian architects: Ciro Lomonte and Guido Santoro, who in a small parish church in Sancipirello reached for the primal instinct of beauty in sacred art and, through simple forms, made a kind of sacralization of the "naked" church interior.
CONTEMPORARY TRENDS IN THE ACCESSIBILITY OF CULTURAL FACILITIES, BASED ON THE EXAMPLE OF BARCELONA
Authors:   Architecture. Silesian University of Technology in Gliwice, Poland, Szewczenko Anna , Tadla-Borowska Natalia ,   Architecture. Silesian University of Technology in Gliwice, Poland
Published: December 2023

Cultural facilities play an important role in urban social life. It is a meeting place between culture and the participants in urban life, understood today as a place for discussion, exchange of ideas. To allow these processes to take place, it is necessary to ensure accessibility in all areas. The aim of this article is to analyse exemplary directions of activities in cultural venues in Barcelona as a city implementing accessibility in the broadest sense, including supporting activities in venues such as theatres and museums, for example. Based on the results of the research, an attempt was made to develop an accessibility model capturing spatial, technological, organisational and communication and information activities. The research involved a literature review and site visits to four cultural venues in Barcelona.
How Do Perpetrators Become Visible? Photographs and Visibility Dispositifs in the Identification of a Perpetrator During the Argentine Dictatorship
Authors: Feld Claudia
Published: December 2023

This article examines the connections between forced disappearances in Argentina, the public visibility of perpetrators, and the role of photographic images. It focuses on Alfredo Astiz, who was identified during the dictatorship for his involvement in two internationally renowned abduction cases: the disappearance of the Swedish teenager Dagmar Hagelin and the abduction of the French nuns Alice Domon and Léonie Duquet, who were taken to the Navy Mechanics School or ESMA (Escuela de Mecánica de la Armada). By analysing two series of photographs of Astiz that were published during the dictatorship, along with the accompanying texts and paratexts circulating at the time, and within the contexts, settings, and media that facilitated the identification and visibility of this perpetrator, this article sheds light on the dynamics, limitations, tensions, and opportunities presented by images of the figure of the perpetrator. The article proposes to understand visibility dispositifs as specific tools for investigating the visual representation of perpetrators and the complex processes involved in constructing meanings around perpetration over time. In the more specific field of forced disappearance studies, this text aims to discuss the role of images in making perpetrators visible, thus shifting the research focus away from the photographs of victims, which have been extensively examined in previous work. Its uniqueness also lies in considering this issue within a dictatorial rather than a transitional or post-conflict context.
Developing Electronic Student Worksheet based on Probing Prompting Learning Method using Google Form on Social Arithmetic
Authors: Levia Tilza , Maulidiya Della , Siagian Teddy Alfra
Published: December 2023

This study aims to feasibility electronic student worksheet with the Probing Prompting learning method using Google Form on social arithmetic material for valid, practical, and effective. This research was used an ADDIE model, that consist of analyze, design, development, implementation, and evaluation. The research instrument include of validation sheets, practicality sheets, and tests of mathematical problem solving abilities. This research produced an electronic student worksheets based on probing prompting usng Google Form on social arithmetic material.  of seventh-grade students was included in the following criteria: 1) Very valid based on content assessment, construct assessment, language assessment, media assessment; 2) Practical based on 11 aspects of assessment; 3) Effectiveness based on classical learning mastery, namely 90% of students who complete score ≥70 and the results of the N-Gain calculation of problem solving abilities with an average N-Gain of 0.77 are in the high category.

 

Penelitian ini bertujuan untuk menghasilkan lembar kerja peserta didik berbentuk elektronik dengan metode pembelajaran Probing Prompting menggunakan Google Form materi aritmatika sosial yang valid, praktis, dan efektif. Penelitian ini adalah penelitian dan pengembangan model ADDIE, yaitu analisis, desain, pengembangan, implementasi, dan evaluasi. Instrumen penelitian ini terdiri dari lembar validasi, lembar kepraktisan, dan tes kemampuan pemecahan masalah matematis. Penelitian ini menghasilkan LKPD elektronik berbasis probing prompting menggunakan Google Form pada materi aritmatika sosial peserta didik kelas VII memenuhi kriteria: 1) Sangat valid berdasarkan aspek penilaian isi, aspek konstruk, aspek bahasa, aspek media; 2) Praktis; 3) Efektif berdasarkan ketuntasan belajar klasikal yaitu 90% peserta didik yang tuntas memperoleh nilai ≥70 dan hasil perhitungan N-Gain kemampuan pemecahan masalah dengan rata-rata N-Gain 0,77 berada pada kategoti tinggi.
Double-Barrel Vascularized Free Fibula Flap for Reconstruction of Sternal Nonunion with Bone Defect
Authors: Perez-Otero Sofía , Bekisz Jonathan M. , Sánchez-Navarro Gerardo , Chang Stephanie H. , Levine Jamie P.
Published: December 2023

Case:

Given the rare incidence of sternal nonunion after traumatic injury, literature describing the management of posttraumatic sternal reconstruction is limited. We present a case of a 54-year-old man with a history of traumatic chest wall injury with multiple unsuccessful attempts at sternal repair who presented with chronic sternal nonunion and persistent bone defect. Sternal reconstruction using a vascularized double-barrel free fibula flap with rigid fixation in multiple planes was performed, with confirmed bony union at 6 months.

Conclusion:

This novel approach to sternal nonunion management allowed effective bridging of posttraumatic sternal bone defects while facilitating osseous integration and long-term stabilization.
Melting of Subducted Continental Crust in the Cimmerian Collisional Orogenic Belt, NE Iran
Authors: Yang Zong-Yong , Bi Xian-Wu , Zhu Jing-Jing , Hu Ruizhong , Hollings Pete , Sholeh Ali , Pan Li-Chuan , Huang Ming-Liang
Published: December 2023

The subduction of continental crust in orogenic belts that are not associated with high-pressure metamorphism is still poorly understood. The Late Triassic postcollisional granitic rocks of NE Iran are related to the convergence between the Central Iran terrane and the Turan terrane on the southern margin of the Eurasian continent. They intruded into the Paleo-Tethyan suture between the Central Iran and Turan terranes. Granitoids of the Torbat-e-Jam pluton were emplaced at ca. 217 Ma, and their moderately high SiO2 (>64 wt. %), low MgO contents (mostly <2 wt. %), slightly depleted Sr-Nd, and zircon Hf isotopes suggest partial melting of a juvenile crust. Granodiorites from NW and SE Mashhad were emplaced at ca. 217 and 200 Ma, and their geochemical features and enriched Sr-Nd and zircon Hf isotopes suggest melting of continental crust. Inherited zircon cores in both the NW and SE Mashhad intrusions have dominant age peaks of ca. 540 and 770 Ma, similar to the age spectrum of adjacent Paleozoic sediments derived from the Central Iran terrane, but distinct from Triassic sediments sourced from the Turan terrane. The inherited zircon cores cannot be explained by crustal contamination during magma ascent, rather the age pattern of inherited zircon cores coincides with major magmatic events in the Central Iran terrane and fingerprint their source, suggesting partial melting of the subducted Central Iran continental crust. This study suggests that the melting of subducted continental crust can occur in simple collisional belts, rather than being confined to ultrahigh-pressure metamorphic orogenic belts.
Feature Extraction in Time-Lapse Seismic Using Deep Learning for Data Assimilation
Authors: Exterkoetter Rodrigo , Dutra Gustavo R. , de Figueiredo Leandro P. , Bordignon Fernando , Neto Gilson M. S. , Emerick Alexandre A.
Published: December 2023

Assimilation of time-lapse (4D) seismic data with ensemble-based methods is challenging because of the massive number of data points. This situation requires excessive computational time and memory usage during the model updating step. We addressed this problem using a deep convolutional autoencoder to extract the relevant features of 4D images and generate a reduced representation of the data. The architecture of the autoencoder is based on the VGG-19 network, a deep convolutional architecture with 19 layers well-known for its effectiveness in image classification and object recognition. Some advantages of VGG-19 are the possibility of using some pretrained convolutional layers to create a feature extractor and taking advantage of the transfer learning technique to address other related problem domains. Using a pretrained model bypasses the need for large training data sets and avoids the high computational demand to train a deep network. For further improvements in the reconstruction of the seismic images, we apply a fine-tuning of the weights of the latent convolutional layer. We propose to use a fully convolutional architecture, which allows the application of distance-based localization during data assimilation with the ensemble smoother with multiple data assimilation (ES-MDA). The performance of the proposed method is investigated in a synthetic benchmark problem with realistic settings. We evaluate the methodology with three variants of the autoencoder, each one with a different level of data reduction. The experiments indicate that it is possible to use latent representations with major data reductions without impairing the quality of the data assimilation. Additionally, we compare central processing unit (CPU) and graphics processing unit (GPU) implementations of the ES-MDA update step and show in another synthetic problem that the reduction in the number of data points obtained with the application of the deep autoencoder may provide a substantial improvement in the overall computation cost of the data assimilation for large reservoir models.