bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 5 from A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells
Authors: Visnyei Koppany , Onodera Hideyuki , Damoiseaux Robert , Saigusa Kuniyasu , Petrosyan Syuzanna , De Vries David , Ferrari Denise , Saxe Jonathan , Panosyan Eduard H. , Masterman-Smith Michael , Mottahedeh Jack , Bradley Kenneth A. , Huang Jing , Sabatti Chiara , Nakano Ichiro , Kornblum Harley I.
Published: April 2023

PDF File - (61K) - OLDA, Emetine, 5256360 and 5560509 decrease clonal sphere formation in low passage GBM312 Graphs show a concentration-dependent reduction of clonal neurosphere size, neurosphere number as well as total cell mass. Error bars represent SEM.
Supplementary Figure 3 from A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells
Authors: Visnyei Koppany , Onodera Hideyuki , Damoiseaux Robert , Saigusa Kuniyasu , Petrosyan Syuzanna , De Vries David , Ferrari Denise , Saxe Jonathan , Panosyan Eduard H. , Masterman-Smith Michael , Mottahedeh Jack , Bradley Kenneth A. , Huang Jing , Sabatti Chiara , Nakano Ichiro , Kornblum Harley I.
Published: April 2023

PDF File - (55K) - Sensitivity of GBM cells to OLDA, PALDA and NADA changes as a function of time, for which the cells were cultured in GSC -enriching media GBM107 cells were exposed to GSC -enriching media for increasing amounts of time and were then screened for sensitivity to dopaminergic cannabinoid compounds. While screening in serum-containing media requires a higher compound concentration due to the protective effect of serum in general, serum-derived cells become more and more sensitive towards GSC -specific compounds over time after transfer into sphere media (A, B, C). Such a difference is not present using non-GSC selective chemotherapeutics (D) or non-GBM control cells (E, F). ('ser in ser': serum derived cells screened in serum media; 'ser in sph': serum derived cells screened in sphere media; '1d sph': serum derived cells were cultured in sphere media for one day before the screen, etc.)
Supplementary Figure 8 from Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput Screening
Authors: Bialkowska Agnieszka B. , Crisp Melissa , Bannister Thomas , He Yuanjun , Chowdhury Sarwat , Schürer Stephan , Chase Peter , Spicer Timothy , Madoux Franck , Tian Chenlu , Hodder Peter , Zaharevitz Daniel , Yang Vincent W.
Published: April 2023

PDF file - 36K
Supplementary Figure 2 from Engineering and Therapeutic Application of Single-Chain Bivalent TGF-β Family Traps
Authors: Zwaagstra John C. , Sulea Traian , Baardsnes Jason , Lenferink Anne E.G. , Collins Cathy , Cantin Christiane , Paul-Roc Béatrice , Grothe Suzanne , Hossain Sazzad , Richer Louis-Philippe , L'Abbé Denis , Tom Roseanne , Cass Brian , Durocher Yves , O'Connor-McCourt Maureen D.
Published: April 2023

PDF file, 2243KB, Molecular dynamics analysis of the (TBRII)2 trap in complex with TGF-B3.
Supplementary Figures 1-3 from Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells
Authors: Klinge Carolyn M. , Radde Brandie N. , Imbert-Fernandez Yoannis , Teng Yun , Ivanova Margarita M. , Abner Sabra M. , Martin Alexandra L.
Published: April 2023

PDF file - 189K
Supplementary Figure 2 from Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth
Authors: Zhao Huajun , Lo Yuan-Hung , Ma Li , Waltz Susan E. , Gray Jerilyn K. , Hung Mien-Chie , Wang Shao-Chun
Published: April 2023

Supplementary Figure 2 from Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth
Supplementary Figure 1 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling
Authors: Barkan Batya , Kloog Yoel , Ehrlich Marcelo
Published: April 2023

Supplementary Figure 1 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling
Supplementary Figure 5 from In Situ Vaccination with CD204 Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer
Authors: Guo Chunqing , Yi Huanfa , Yu Xiaofei , Zuo Daming , Qian Jie , Yang Gary , Foster Barbara A. , Subjeck John R. , Sun Xiaolei , Mikkelsen Ross B. , Fisher Paul B. , Wang Xiang-Yang
Published: April 2023

PDF file, 662K, SRA/CD204 silencing in DCs increases IFN-γ production by CD8+ cells, not CD4+ cells, after combinatorial therapy of RT and in situ DC vaccination.
Supplementary Figure Legends 1-6 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Authors: Li Jing , Cao Bo , Liu Xichun , Fu Xueqi , Xiong Zhenggang , Chen Li , Sartor Oliver , Dong Yan , Zhang Haitao
Published: April 2023

Supplementary Figure Legends 1-6 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Supplementary Figures 1-8 from Targeting Radiation-Induced G2 Checkpoint Activation with the Wee-1 Inhibitor MK-1775 in Glioblastoma Cell Lines
Authors: Sarcar Bhaswati , Prabhu Antony H. , Shumway Stuart D. , Xu Yang , Demuth Tim , Chinnaiyan Prakash
Published: April 2023

PDF file - 977K
Supplementary Figure 6 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Authors: Li Jing , Cao Bo , Liu Xichun , Fu Xueqi , Xiong Zhenggang , Chen Li , Sartor Oliver , Dong Yan , Zhang Haitao
Published: April 2023

Supplementary Figure 6 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Supplementary Figure 2 from Spliceosome-Mediated RNA Trans-Splicing Facilitates Targeted Delivery of Suicide Genes to Cancer Cells
Authors: Gruber Christina , Gratz Iris K. , Murauer Eva M. , Mayr Elisabeth , Koller Ulrich , Bruckner-Tuderman Leena , Meneguzzi Guerrino , Hintner Helmut , Bauer Johann W.
Published: April 2023

Supplementary Figure 2 from Spliceosome-Mediated RNA Trans-Splicing Facilitates Targeted Delivery of Suicide Genes to Cancer Cells
Supplementary Figure 3 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Authors: Scaltriti Maurizio , Serra Violeta , Normant Emmanuel , Guzman Marta , Rodriguez Olga , Lim Alice R. , Slocum Kelly L. , West Kip A. , Rodriguez Varenka , Prudkin Ludmila , Jimenez José , Aura Claudia , Baselga José
Published: April 2023

Supplementary Figure 3 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Supplementary Figure 1 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Authors: Scaltriti Maurizio , Serra Violeta , Normant Emmanuel , Guzman Marta , Rodriguez Olga , Lim Alice R. , Slocum Kelly L. , West Kip A. , Rodriguez Varenka , Prudkin Ludmila , Jimenez José , Aura Claudia , Baselga José
Published: April 2023

Supplementary Figure 1 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Supplementary Figure 2 from The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells
Authors: Zhao Liqun , Yue Ping , Lonial Sagar , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

PDF file - 137K
Supplementary Figures 1-4 from Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft
Authors: Senra Joana M. , Telfer Brian A. , Cherry Kim E. , McCrudden Cian M. , Hirst David G. , O'Connor Mark J. , Wedge Stephen R. , Stratford Ian J.
Published: April 2023

PDF file - 491K
Supplementary Figures 1-7 from Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
Authors: Natoni Alessandro , Murillo Laura S. , Kliszczak Anna E. , Catherwood Mark A. , Montagnoli Alessia , Samali Afshin , O'Dwyer Michael , Santocanale Corrado
Published: April 2023

PDF file - 523K
Supplementary Tables 1-2, Figures 1-7 from Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1
Authors: Tardif Keith D. , Rogers Aaron , Cassiano Jared , Roth Bruce L. , Cimbora Daniel M. , McKinnon Rena , Peterson Ashley , Douce Thomas B. , Robinson Rosann , Dorweiler Irene , Davis Thaylon , Hess Mark A. , Ostanin Kirill , Papac Damon I. , Baichwal Vijay , McAlexander Ian , Willardsen J. Adam , Saunders Michael , Christophe Hoarau , Kumar D. Vijay , Wettstein Daniel A. , Carlson Robert O. , Williams Brandi L.
Published: April 2023

PDF file - 123K
Supplementary Figures 1-4 from NF-κB Is Required for Smac Mimetic-Mediated Sensitization of Glioblastoma Cells for γ-Irradiation–Induced Apoptosis
Authors: Berger Rebecca , Jennewein Claudia , Marschall Viola , Karl Sabine , Cristofanon Silvia , Wagner Liane , Vellanki Sri HariKrishna , Hehlgans Stephanie , Rödel Franz , Debatin Klaus-Michael , Ludolph Albert C. , Fulda Simone
Published: April 2023

PDF file-589KB
Supplementary Figure 1 from The Clinically Active PARP Inhibitor AG014699 Ameliorates Cardiotoxicity but Does Not Enhance the Efficacy of Doxorubicin, despite Improving Tumor Perfusion and Radiation Response in Mice
Authors: Ali Majid , Kamjoo Marzieh , Thomas Huw D. , Kyle Suzanne , Pavlovska Ivanda , Babur Muhammed , Telfer Brian A. , Curtin Nicola J. , Williams Kaye J.
Published: April 2023

PDF file - 81K
Supplementary Figure 3 from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface
Authors: Tang Zhewei , Feng Mingqian , Gao Wei , Phung Yen , Chen Weizao , Chaudhary Amit , Croix Brad St. , Qian Min , Dimitrov Dimiter S. , Ho Mitchell
Published: April 2023

PDF file - 1884K, CDC analysis of HN1(scFv)-hFc and SDS-PAGE analysis of molecular weight discrepancy of human antibodies.
Supplementary Figures 1 & 2 from TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells
Authors: Fitzgerald Daniel P. , Emerson David L. , Qian Yongzhen , Anwar Talha , Liewehr David J. , Steinberg Seth M. , Silberman Sandra , Palmieri Diane , Steeg Patricia S.
Published: April 2023

PDF file, 785KB, High dose TPI-287 inhibited proliferation and increased acetylated tubulin in primary tumors while low dose TPI-287 had no effect on brain metastasis prevention.
Supplementary Figure 6 from Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib
Authors: Giles Keith M. , Kalinowski Felicity C. , Candy Patrick A. , Epis Michael R. , Zhang Priscilla M. , Redfern Andrew D. , Stuart Lisa M. , Goodall Gregory J. , Leedman Peter J.
Published: April 2023

PDF - 75KB, Supplementary Figure S6. Analysis of NF-kB activity between HN5 and HN5-ER cells and following transfection of HN5-ER cells with miR-34a or Axl siRNAs.
Supplementary Figure 4 from Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib
Authors: Giles Keith M. , Kalinowski Felicity C. , Candy Patrick A. , Epis Michael R. , Zhang Priscilla M. , Redfern Andrew D. , Stuart Lisa M. , Goodall Gregory J. , Leedman Peter J.
Published: April 2023

PDF - 13KB, Supplementary Figure S4. Sensitivity of HN5-ER cells to co-treatment with gefitinib and R428.
Supplementary Figure 1 from Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Authors: Ueno Koji , Hirata Hiroshi , Majid Shahana , Yamamura Soichiro , Shahryari Varahram , Tabatabai Z. Laura , Hinoda Yuji , Dahiya Rajvir
Published: April 2023

PDF file - 9.6MB
Supplementary Methods from Targeting Olfactomedin-like 3 Inhibits Tumor Growth by Impairing Angiogenesis and Pericyte Coverage
Authors: Miljkovic-Licina Marijana , Hammel Philippe , Garrido-Urbani Sarah , Lee Boris P.-L. , Meguenani Mehdi , Chaabane Chiraz , Bochaton-Piallat Marie-Luce , Imhof Beat A.
Published: April 2023

PDF file - 118K
Supplementary Table 4 from EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics
Authors: Arcila Maria E. , Nafa Khedoudja , Chaft Jamie E. , Rekhtman Natasha , Lau Christopher , Reva Boris A. , Zakowski Maureen F. , Kris Mark G. , Ladanyi Marc
Published: April 2023

PDF file - 54K, Morphologic assessment of tumors harboring EGFR exon 20 insertions and comparison to a control group with classical EGFR sensitizing mutations
Supplementary Table 2 from EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics
Authors: Arcila Maria E. , Nafa Khedoudja , Chaft Jamie E. , Rekhtman Natasha , Lau Christopher , Reva Boris A. , Zakowski Maureen F. , Kris Mark G. , Ladanyi Marc
Published: April 2023

PDF file - 66K, Summary of all mutations identified through clinical and extended mass spectrometry genotyping (n=1500)
Supplementary Figure 2 from EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics
Authors: Arcila Maria E. , Nafa Khedoudja , Chaft Jamie E. , Rekhtman Natasha , Lau Christopher , Reva Boris A. , Zakowski Maureen F. , Kris Mark G. , Ladanyi Marc
Published: April 2023

PDF file - 1601K, Representative case harboring a 9pb insertion mutation V769_D770insASV
Supplementary Figure Legend from YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels
Authors: Kumar Bhavna , Yadav Arti , Lang James C. , Cipolla Michael J. , Schmitt Alessandra C. , Arradaza Nicole , Teknos Theodoros N. , Kumar Pawan
Published: April 2023

PDF file, 30KB.
Supplementary Figure 6 from A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Authors: Lim Yi Chieh , Roberts Tara L. , Day Bryan W. , Harding Angus , Kozlov Sergei , Kijas Amanda W. , Ensbey Kathleen S. , Walker David G. , Lavin Martin F.
Published: April 2023

PDF file, 244K, BRCA1 foci demonstrate similar kinetics to Rad51 foci after exposure to ionizing radiation.
Supplementary Figure Legend from Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage
Authors: Lee Hae-June , Yoon Changhwan , Schmidt Benjamin , Park Do Joong , Zhang Alexia Y. , Erkizan Hayriye V. , Toretsky Jeffrey A. , Kirsch David G. , Yoon Sam S.
Published: April 2023

PDF - 51KB
Supplementary Table 2 from Prognostic Role of Lemur Tyrosine Kinase-3 Germline Polymorphisms in Adjuvant Gastric Cancer in Japan and the United States
Authors: Wakatsuki Takeru , LaBonte Melissa J. , Bohanes Pierre O. , Zhang Wu , Yang Dongyun , Azuma Mizutomo , Barzi Afsaneh , Ning Yan , Loupakis Fotios , Saadat Siamak , Volz Nico , Stintzing Sebastian , El-Khoueiry Rita , Koizumi Wasaburo , Watanabe Masahiko , Shah Manish , Stebbing Justin , Giamas Georgios , Lenz Heinz-Josef
Published: April 2023

PDF - 87K, Table breakdown comparing the genotype frequency of the LMTK3 polymorphisms analyzed (rs99896661 and rs8108419) in the Japanese and US cohorts.
Supplementary Table 3 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Authors: Allen Wendy L. , Turkington Richard C. , Stevenson Leanne , Carson Gail , Coyle Vicky M. , Hector Suzanne , Dunne Philip , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 261K, List showing 1986 genes that are uniquely altered following SN38 treatment over time in HCT116 p53null cells only. Genes have been normalised and filtered as stated in the materials and methods
Supplementary Figure Legends from A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth In Vitro and In Vivo
Authors: Kuruma Hidetoshi , Matsumoto Hiroaki , Shiota Masaki , Bishop Jennifer , Lamoureux Francois , Thomas Christian , Briere David , Los Gerrit , Gleave Martin , Fanjul Andrea , Zoubeidi Amina
Published: April 2023

PDF, 58K, Legends describing all the supplementary data
Supplementary Figure Legend from Induction of Endoplasmic Reticulum Stress by Sorafenib and Activation of NF-κB by Lestaurtinib as a Novel Resistance Mechanism in Hodgkin Lymphoma Cell Lines
Authors: Holz Meike Stefanie , Janning Angela , Renné Christoph , Gattenlöhner Stefan , Spieker Tilmann , Bräuninger Andreas
Published: April 2023

PDF file - 46K
Supplementary Figures and Table from Catalase Abrogates β-Lapachone–Induced PARP1 Hyperactivation–Directed Programmed Necrosis in NQO1-Positive Breast Cancers
Authors: Bey Erik A. , Reinicke Kathryn E. , Srougi Melissa C. , Varnes Marie , Anderson Vernon E. , Pink John J. , Li Long Shan , Patel Malina , Cao Lifen , Moore Zachary , Rommel Amy , Boatman Michael , Lewis Cheryl , Euhus David M. , Bornmann William G. , Buchsbaum Donald J. , Spitz Douglas R. , Gao Jinming , Boothman David A.
Published: April 2023

PDF file, 1661K, Supplemental Figure S1- Chemical Structures. Supplemental Figure S2-Oxygen Consumption in MCF-7 Cells treated with or without betalapchone and dicoumarol. Supplemental Figure S2 legend. Supplemental Figure S3-Survival assay for normal mammary epithelial cells treated with betalapachone with or without dicoumarol. Supplemental Figure S3 legend. Supplemental Figure S4-Survival assay for MDA-MB231 cells treated with or without quinones and ROS scavengers. Supplemental Figure S4 legend. Supplemental Figure S5-Westernblot of MCF-7 cells treated with betalapachone with or without catalase. Supplemental Figure S5 legend. Supplemental Figure S6-Proteolysis of PARP in MCF-7 cells treated with betalapachone or staurosporine. Supplemental Figure S6 legend. Supplemental Figure S7- NQO1 mediated futile cycle of betalapachone. Supplemental Figure S7 legend. Supplemental Figure S8- Western blot and analysis of NQO1 to Catalase ratios in Breast Cancer Cell lines. Supplemental Table 1- NQO1 enzymatic activity in breast cancer cell lines. Supplemental Table 1 legend.
Supplementary Figure 1 from Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer
Authors: Chen Jing , Wang Jieqiong , Lin Lei , He Lijun , Wu Yuanyuan , Zhang Li , Yi Zhengfang , Chen Yihua , Pang Xiufeng , Liu Mingyao
Published: April 2023

PDF file - 2.3MB
Supplementary Methods and Materials, Supplementary Figures 1-8, Supplementary Figure Legends, Supplementary Tables 1-3 from Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells
Authors: Sapra Puja , Damelin Marc , DiJoseph John , Marquette Kimberly , Geles Kenneth G. , Golas Jonathon , Dougher Maureen , Narayanan Bitha , Giannakou Andreas , Khandke Kiran , Dushin Russell , Ernstoff Elana , Lucas Judy , Leal Mauricio , Hu George , O'Donnell Christopher J. , Tchistiakova Lioudmila , Abraham Robert T. , Gerber Hans-Peter
Published: April 2023

PDF file-458KB, Supplementary Figure S1. Representation of A1mcMMAF and its proposed processing., Supplementary Figure S2. Chromatographic characterization of A1mcMMAF., Supplementary Figure S3. LC-MS analysis of A1mcMMAF ADC., Supplementary Figure S4. Anti-5T4 A1 antibody binding to 5T4 orthologs., Supplementary Figure S5. Anti-5T4 A1 antibody binding to cancer cell lines., Supplementary Figure S6. Cytotoxic activity of A1mcMMAF on TIC-enriched TUM622 spheroids., Supplementary Figure S7. In vivo pharmacology in MDAMB435/5T4., Supplementary Figure S8. No activity of A1mcMMAF in a 5T4-negative tumor. Supplementary Table S1. Humanized A1 BIAcore Affinity Constants for Human and Cynomolgus Monkey 5T4 at pH 7.4 Supplementary Table S2. Representative internalization in MDAMB435/5T4. Supplementary Table S3. Comparison of in vitro cytotoxicities of ADC vs. free payload (IC50 values expressed in nM auristatin).
Supplementary Table 1 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 81K
Supplementary Figure 7 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 960K
Supplementary Figure 6 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 915K
Supplementary Figure 1 from Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer
Authors: Wainberg Zev A. , Anghel Adrian , Rogers Amy M. , Desai Amrita J. , Kalous Ondrej , Conklin Dylan , Ayala Raul , O'Brien Neil A. , Quadt Cornelia , Akimov Mikhail , Slamon Dennis J. , Finn Richard S.
Published: April 2023

Supplementary Figure 1 PDF file - 204K, Effects on downstream signaling in non-HER2 amplified gastric cancer cells
Supplementary Figure 2 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 2.9MB
Supplementary Figure 1 from The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
Authors: Mizuma Masamichi , Rasheed Zeshaan A. , Yabuuchi Shinichi , Omura Noriyuki , Campbell Nathaniel R. , de Wilde Roeland F. , De Oliveira Elizabeth , Zhang Qing , Puig Oscar , Matsui William , Hidalgo Manuel , Maitra Anirban , Rajeshkumar N.V.
Published: April 2023

PDF file, 76K, FACS plots for ALDH and CD44 and CD24 controls.
Supplementary Figure 2 from The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells
Authors: Wangpaichitr Medhi , Sullivan Elizabeth J. , Theodoropoulos George , Wu Chunjing , You Min , Feun Lynn G. , Lampidis Theodore J. , Kuo Macus T. , Savaraj Niramol
Published: April 2023

PDF file - 82K
Supplementary Figure 1 from The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells
Authors: Wangpaichitr Medhi , Sullivan Elizabeth J. , Theodoropoulos George , Wu Chunjing , You Min , Feun Lynn G. , Lampidis Theodore J. , Kuo Macus T. , Savaraj Niramol
Published: April 2023

PDF file - 328K
Supplementary Table 4 from A High-Throughput Panel for Identifying Clinically Relevant Mutation Profiles in Melanoma
Authors: Dutton-Regester Ken , Irwin Darryl , Hunt Priscilla , Aoude Lauren G. , Tembe Varsha , Pupo Gulietta M. , Lanagan Cathy , Carter Candace D. , O'Connor Linda , O'Rourke Michael , Scolyer Richard A. , Mann Graham J. , Schmidt Christopher W. , Herington Adrian , Hayward Nicholas K.
Published: April 2023

PDF file - 210K, Results of matching/ duplicate samples.
Supplementary Table 2 from A High-Throughput Panel for Identifying Clinically Relevant Mutation Profiles in Melanoma
Authors: Dutton-Regester Ken , Irwin Darryl , Hunt Priscilla , Aoude Lauren G. , Tembe Varsha , Pupo Gulietta M. , Lanagan Cathy , Carter Candace D. , O'Connor Linda , O'Rourke Michael , Scolyer Richard A. , Mann Graham J. , Schmidt Christopher W. , Herington Adrian , Hayward Nicholas K.
Published: April 2023

PDF file - 270K, Mutation List used in confirmation phase.
Supplementary Material: DLDA Classifier IGF Signature from Molecular Predictors of Sensitivity to the Insulin-like Growth Factor 1 Receptor Inhibitor Figitumumab (CP-751,871)
Authors: Pavlicek Adam , Lira Maruja E. , Lee Nathan V. , Ching Keith A. , Ye Jingjing , Cao Joan , Garza Scott J. , Hook Kenneth E. , Ozeck Mark , Shi Stephanie T. , Yuan Jing , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G.
Published: April 2023

PDF file - 64K, Supplementary summary of performance of DLDA gene expression signature classifiers across cell lines including cell line classification and mean number of genes in classifier and including classifier compositions rank ordered by t value.
Supplementary Figure Legend from Inducible Silencing of Protein Kinase D3 Inhibits Secretion of Tumor-Promoting Factors in Prostate Cancer
Authors: LaValle Courtney R. , Zhang Liyong , Xu Shuping , Eiseman Julie L. , Wang Q. Jane
Published: April 2023

PDF file, 82KB.
Supplementary Figure 5 from Inducible Silencing of Protein Kinase D3 Inhibits Secretion of Tumor-Promoting Factors in Prostate Cancer
Authors: LaValle Courtney R. , Zhang Liyong , Xu Shuping , Eiseman Julie L. , Wang Q. Jane
Published: April 2023

PDF File, 132KB, PKD3 knockdown reduces MMP-9 activity in conditioned medium, but does not alter MMP-9 or MMP-14 transcripts.
Supplementary Figure 4 from Therapeutic Mechanism and Efficacy of the Antibody–Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9
Authors: Petrul Heike M. , Schatz Christoph A. , Kopitz Charlotte C. , Adnane Lila , McCabe Timothy J. , Trail Pamela , Ha Sha , Chang Yong S. , Voznesensky Andrei , Ranges Gerald , Tamburini Paul P.
Published: April 2023

PDF file - 62K, Schematical drawing of the anti-CAIX conjugate with the structure of MMAE.
Supplementary Materials and Methods from Selective Photodetection and Photodynamic Therapy for Prostate Cancer through Targeting of Proteolytic Activity
Authors: Zuluaga Maria-Fernanda , Sekkat Nawal , Gabriel Doris , van den Bergh Hubert , Lange Norbert
Published: April 2023

PDF file - 87KB
Supplementary Table 2 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Authors: Liu Yi , Cao Yanyan , Zhang Weihe , Bergmeier Stephen , Qian Yanrong , Akbar Huzoor , Colvin Robert , Ding Juan , Tong Lingying , Wu Shiyong , Hines Jennifer , Chen Xiaozhuo
Published: April 2023

PDF file, 129KB, Blood analysis of WZB117-treated tumor-bearing mice.
Supplementary Figure Legend from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Authors: Liu Yi , Cao Yanyan , Zhang Weihe , Bergmeier Stephen , Qian Yanrong , Akbar Huzoor , Colvin Robert , Ding Juan , Tong Lingying , Wu Shiyong , Hines Jennifer , Chen Xiaozhuo
Published: April 2023

PDF file, 61KB.
Supplementary Tables 1 - 3 from Reversing Effect of Ring Finger Protein 43 Inhibition on Malignant Phenotypes of human Hepatocellular Carcinoma
Authors: Xing Chunyang , Zhou Wuhua , Ding Songming , Xie Haiyang , Zhang Wu , Yang Zhe , Wei Bajin , Chen Kangjie , Su Rong , Cheng Jun , Zheng Shusen , Zhou Lin
Published: April 2023

PDF file - 140K, Primer sequences, Primary antibodies, and Differentially expressed genes after RNF43 knockdown
Supplementary Figure 4 from Reversing Effect of Ring Finger Protein 43 Inhibition on Malignant Phenotypes of human Hepatocellular Carcinoma
Authors: Xing Chunyang , Zhou Wuhua , Ding Songming , Xie Haiyang , Zhang Wu , Yang Zhe , Wei Bajin , Chen Kangjie , Su Rong , Cheng Jun , Zheng Shusen , Zhou Lin
Published: April 2023

PDF file - 6281K, Knockdown of RNF43 inhibits invasion, migration and ECM adhesion of HCC Cells. Cells were transfected with indicated siRNAs. Seventy-two hours after transfection, the impact of RNF43 knockdown on invasion, migration and ECM adhesion was evaluated. (A) Representative images showing decreased migration in RNF43 siRNA-transfected HCC cells. (B) Representative images of wound-healing experiments. (C) The impact of RNF43 knockdown on adhesion of SMMC-7721 cells to different extracellular matrix proteins (n=3, **p < 0.01). (D) Knockdown of RNF43 inhibited the expression of Integrin β4. (E) Knockdown of RNF43 showed no effect on E-cadherin expression.
Supplementary Figures 1-4, Table 1 from Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3
Authors: McDonagh Charlotte F. , Huhalov Alexandra , Harms Brian D. , Adams Sharlene , Paragas Violette , Oyama Shinji , Zhang Bo , Luus Lia , Overland Ryan , Nguyen Stephanie , Gu Jinming , Kohli Neeraj , Wallace Matt , Feldhaus Michael J. , Kudla Arthur J. , Schoeberl Birgit , Nielsen Ulrik B.
Published: April 2023

PDF file - 189K
Supplementary Figure 2 from Enhancement of Synthetic Lethality via Combinations of ABT-888, a PARP Inhibitor, and Carboplatin In Vitro and In Vivo Using BRCA1 and BRCA2 Isogenic Models
Authors: Clark Caroline C. , Weitzel Jeffrey N. , O'Connor Timothy R.
Published: April 2023

PDF file, 84K, SUPPLEMENTARY FIGURE S2. Calculated combination index (CI) values for ABT-888/carboplatin or ABT-888/cisplatin treatments of mESCs and human tumor cell lines. Data used for these plots is found in Supplementary Table 2. (a) CI values for treatment of Brca1 mESCs with ABT-888 in combination with cisplatin or carboplatin. Filled circles, ABT-888/carboplatin combinations; open circles, ABT-888/cisplatin combinations. Area between the horizontal lines represents additivity, area above the upper horizontal line represents antagonism, and area below the lower horizontal line represents synergism. (b) CI values for treatment of Brca2 mESCs with ABT-888 in combination with either cisplatin or carboplatin. Filled circles, ABT-888/carboplatin combinations; open circles, ABT-888/cisplatin combinations. (c) CI values for treatment of HC1937 (BRCA1-deficient) cells with ABT-888/carboplatin. (d) CI values for treatment of HC1937 (BRCA2-deficient) cells with ABT-888/carboplatin. (e) CI values for treatment of V-C8 (BRCA2-deficient) cells with ABT-888/carboplatin.
Supplementary Table 1 from Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells
Authors: Venturelli Sascha , Berger Alexander , Weiland Timo , Essmann Frank , Waibel Michaela , Nuebling Tina , Häcker Sabine , Schenk Martin , Schulze-Osthoff Klaus , Salih Helmut R. , Fulda Simone , Sipos Bence , Johnstone Ricky W. , Lauer Ulrich M. , Bitzer Michael
Published: April 2023

PDF file - 32K, 5-aza-dC induces an increase of cellular diameter in HepG2 cells.
Supplemental Figure 4 from A Novel Monoclonal Antibody to Secreted Frizzled-Related Protein 2 Inhibits Tumor Growth
Authors: Fontenot Emily , Rossi Emma , Mumper Russell , Snyder Stephanie , Siamakpour-Reihani Sharareh , Ma Ping , Hilliard Eleanor , Bone Bradley , Ketelsen David , Santos Charlene , Patterson Cam , Klauber-DeMore Nancy
Published: April 2023

Full length gels
Supplementary Figure 1 from Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells
Authors: Venturelli Sascha , Berger Alexander , Weiland Timo , Essmann Frank , Waibel Michaela , Nuebling Tina , Häcker Sabine , Schenk Martin , Schulze-Osthoff Klaus , Salih Helmut R. , Fulda Simone , Sipos Bence , Johnstone Ricky W. , Lauer Ulrich M. , Bitzer Michael
Published: April 2023

PDF file - 157K, Change of cytokine release of HepG2 cells under treatment.
Supplementary Figure 3 from A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists
Authors: Chenna Venugopal , Hu Chaoxin , Pramanik Dipankar , Aftab Blake T. , Karikari Collins , Campbell Nathaniel R. , Hong Seung-Mo , Zhao Ming , Rudek Michelle A. , Khan Saeed R. , Rudin Charles M. , Maitra Anirban
Published: April 2023

PDF file - 125K
Supplementary Figures S1-S5; Supplementary Tables S1-S4; and Supplementary Materials & Methods from A Heterodimeric Fc-Based Bispecific Antibody Simultaneously Targeting VEGFR-2 and Met Exhibits Potent Antitumor Activity
Authors: Choi Hye-Ji , Kim Ye-Jin , Lee Sangho , Kim Yong-Sung
Published: April 2023

PDF file - 596K, Figure S1: Sequence alignment of CH3 domain of human IgG isotypes to compare the mutation sites introduced for heterodimeric Fc variants between our study and other approaches. Figure S2 : The vector maps of the scFv-Fc/Fc expression system and western blotting analysis of the purified scFv-Fc/Fc proteins carrying the indicated CH3 variant pair. Figure S3 : SPR data showing the kinetic interactions of msMet, tanibirumab, and bsVeMet antibodies with the antigens, Met and VEGFR-2. Figure S4: FACS data showing binding profiles of the msMet, tanibirumab and bsVeMet antibodies to HUVECs and MKN45 cells and effects of the antibodies on the cellular proliferation and signaling of the endothelial HUVECs stimulated by single ligand HGF or VEGF alone. Figure S5: Effects of the msMet, tanibirumab and bsVeMet antibodies on the tube formation of HUVECs stimulated by treatments of HGF and/or VEGF. Table S1: The list of CH3 variant pairs constructed in this study. Table S2: Purification yields of Fc-WT, Fc-EW-RVT, and Fc-KiH proteins obtained from transient expression in HEK293F cells. Table S3: The binding parameters of Fc-WT, Fc-EW-RVT, and Fc-KiH proteins with FcRn and FcγR proteins, determined by SPR analyses. Table S4: The binding parameters of the msMet, tanibirumab and bsVeMet antibodies with the antigens, Met or VEGFR-2, determined by SPR analyses. Supplementary Materials and Methods : Detailed description of Reagents; design and evaluation of heterodimeric Fc; construction, expression, and purification of antibodies; SEC analysis; far-UV CD spectroscopy; DSC experiments; SPR analysis; sandwich ELISA; flow cytometry; cell proliferation assay; western blotting; animal experiments; immunofluorescence of tumor tissues.
Supplementary Figure 1 from A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists
Authors: Chenna Venugopal , Hu Chaoxin , Pramanik Dipankar , Aftab Blake T. , Karikari Collins , Campbell Nathaniel R. , Hong Seung-Mo , Zhao Ming , Rudek Michelle A. , Khan Saeed R. , Rudin Charles M. , Maitra Anirban
Published: April 2023

PDF file - 125K
Supplementary Figure 3 from Cigarette Smoke Induces Aberrant EGF Receptor Activation That Mediates Lung Cancer Development and Resistance to Tyrosine Kinase Inhibitors
Authors: Filosto Simone , Becker Cathleen R. , Goldkorn Tzipora
Published: April 2023

PDF file - 76K
Supplementary Materials and Methods from Poly(β-amino ester) Nanoparticle Delivery of TP53 Has Activity against Small Cell Lung Cancer In Vitro and In Vivo
Authors: Kamat Chandrashekhar D. , Shmueli Ron B. , Connis Nick , Rudin Charles M. , Green Jordan J. , Hann Christine L.
Published: April 2023

PDF file - 64 KB
Supplementary Methods from Effect of Small-Molecule–Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody
Authors: Orcutt Kelly Davis , Rhoden John J. , Ruiz-Yi Benjamin , Frangioni John V. , Wittrup K. Dane
Published: April 2023

PDF file, 113KB, A derivation of the mathematical model of biodistribution is presented.
Supplementary Table 2 from Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
Authors: Kalous Ondrej , Conklin Dylan , Desai Amrita J. , O'Brien Neil A. , Ginther Charles , Anderson Lee , Cohen David J. , Britten Carolyn D. , Taylor Ian , Christensen James G. , Slamon Dennis J. , Finn Richard S.
Published: April 2023

PDF file, 66K, Quantification of proteins from Western blots in Supplementary Figure S7 by densitometry using ImageJ software.
Supplementary Figure Legend from Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
Authors: Kalous Ondrej , Conklin Dylan , Desai Amrita J. , O'Brien Neil A. , Ginther Charles , Anderson Lee , Cohen David J. , Britten Carolyn D. , Taylor Ian , Christensen James G. , Slamon Dennis J. , Finn Richard S.
Published: April 2023

PDF file, 58K.
Supplementary Figure 5 from Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
Authors: Kalous Ondrej , Conklin Dylan , Desai Amrita J. , O'Brien Neil A. , Ginther Charles , Anderson Lee , Cohen David J. , Britten Carolyn D. , Taylor Ian , Christensen James G. , Slamon Dennis J. , Finn Richard S.
Published: April 2023

PDF file, 50K, Effect of dacomitinib on cell cycle in BT-474 and SK-BR-3 parental lines and lines resistant to trastuzumab and lapatinib.
Supplementary Figure 2 from Synergistic Targeting of PI3K/AKT Pathway and Androgen Receptor Axis Significantly Delays Castration-Resistant Prostate Cancer Progression In Vivo
Authors: Thomas Christian , Lamoureux Francois , Crafter Claire , Davies Barry R. , Beraldi Eliana , Fazli Ladan , Kim Soojin , Thaper Daksh , Gleave Martin E. , Zoubeidi Amina
Published: April 2023

PDF - 138 KB, Effect of AZD5363 on body weight
Supplementary Figure 4 from Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
Authors: Kalous Ondrej , Conklin Dylan , Desai Amrita J. , O'Brien Neil A. , Ginther Charles , Anderson Lee , Cohen David J. , Britten Carolyn D. , Taylor Ian , Christensen James G. , Slamon Dennis J. , Finn Richard S.
Published: April 2023

PDF file, 77K, Comparison of the effect of dacomitinib at 48 hrs and 5 days on cell cycle and apoptosis in BT-474 and SK-BR-3 lines.
Supplementary Figure 1 from Synergistic Targeting of PI3K/AKT Pathway and Androgen Receptor Axis Significantly Delays Castration-Resistant Prostate Cancer Progression In Vivo
Authors: Thomas Christian , Lamoureux Francois , Crafter Claire , Davies Barry R. , Beraldi Eliana , Fazli Ladan , Kim Soojin , Thaper Daksh , Gleave Martin E. , Zoubeidi Amina
Published: April 2023

PDF - 67KB, Cartoon showing development of CRPC and treatment regime
Supplementary Table 2 from microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Authors: Zhang Huanyu , Qi Meng , Li Shiwang , Qi Teng , Mei Hong , Huang Kai , Zheng Liduan , Tong Qiangsong
Published: April 2023

PDF file, 19KB, Sequences of pre-miRNAs and small interfering RNAs.
Supplementary Table 1 from microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Authors: Zhang Huanyu , Qi Meng , Li Shiwang , Qi Teng , Mei Hong , Huang Kai , Zheng Liduan , Tong Qiangsong
Published: April 2023

PDF file, 21KB, Primer sets used for RT-PCR and qPCR.
Supplementary Methods, Diagram 1, Figures 1-7 from SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer
Authors: Thomas Rusha , Sharifi Nima
Published: April 2023

PDF file - 425K
Supplementary Figure 4 from Attenuation of Argininosuccinate Lyase Inhibits Cancer Growth via Cyclin A2 and Nitric Oxide
Authors: Huang Hau-Lun , Hsu Hui-Ping , Shieh Shu-Chu , Chang Yung-Sheng , Chen Wei-Ching , Cho Chien-Yu , Teng Chiao-Fang , Su Ih-Jen , Hung Wen-Chun , Lai Ming-Derg
Published: April 2023

PDF - 2058 KB, Knockdown of ASLby shRNA inhibited cell migration in ML-1 cells
Supplementary Figure 1 from Attenuation of Argininosuccinate Lyase Inhibits Cancer Growth via Cyclin A2 and Nitric Oxide
Authors: Huang Hau-Lun , Hsu Hui-Ping , Shieh Shu-Chu , Chang Yung-Sheng , Chen Wei-Ching , Cho Chien-Yu , Teng Chiao-Fang , Su Ih-Jen , Hung Wen-Chun , Lai Ming-Derg
Published: April 2023

PDF - 3467 KB, ASL and GRP78 expression in liver cancer tissue
Supplementary Table 2 from Quantitative Proteomic Profiling Identifies Protein Correlates to EGFR Kinase Inhibition
Authors: Kani Kian , Faca Vitor M. , Hughes Lindsey D. , Zhang Wenxuan , Fang Qiaojun , Shahbaba Babak , Luethy Roland , Erde Jonathan , Schmidt Joanna , Pitteri Sharon J. , Zhang Qing , Katz Jonathan E. , Gross Mitchell E. , Plevritis Sylvia K. , McIntosh Martin W. , Jain Anjali , Hanash Samir , Agus David B. , Mallick Parag
Published: April 2023

PDF file, 5465KB, Quantitation tables for proteins identified and quantified.
Supplementary Figure 1 from Quantitative Proteomic Profiling Identifies Protein Correlates to EGFR Kinase Inhibition
Authors: Kani Kian , Faca Vitor M. , Hughes Lindsey D. , Zhang Wenxuan , Fang Qiaojun , Shahbaba Babak , Luethy Roland , Erde Jonathan , Schmidt Joanna , Pitteri Sharon J. , Zhang Qing , Katz Jonathan E. , Gross Mitchell E. , Plevritis Sylvia K. , McIntosh Martin W. , Jain Anjali , Hanash Samir , Agus David B. , Mallick Parag
Published: April 2023

PDF file, 140KB, Bioinformatic characterization of gefitinib induced protein level changes.
Supplementary Figure Legends from miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR
Authors: Xu Chuanliang , Zeng Qinsong , Xu Weidong , Jiao Li , Chen Yanqiong , Zhang Zhensheng , Wu Chengyao , Jin Taile , Pan Anyin , Wei Rongchao , Yang Bo , Sun Yinghao
Published: April 2023

PDF file - 36KB
Supplementary Table 3 from PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma By Induction of p73 and Noxa
Authors: Saha Manujendra N. , Jiang Hua , Yang Yijun , Reece Donna , Chang Hong
Published: April 2023

PDF - 109KB, Supplementary Table 3. Differential expression of genes in 8226R5 cells treated with PRIMA-1Met.
Supplementary Figure 4 from Combined Therapy with Mutant-Selective EGFR Inhibitor and Met Kinase Inhibitor for Overcoming Erlotinib Resistance in EGFR-Mutant Lung Cancer
Authors: Nakagawa Takayuki , Takeuchi Shinji , Yamada Tadaaki , Nanjo Shigeki , Ishikawa Daisuke , Sano Takako , Kita Kenji , Nakamura Takahiro , Matsumoto Kunio , Suda Kenichi , Mitsudomi Tetsuya , Sekido Yoshitaka , Uenaka Toshimitsu , Yano Seiji
Published: April 2023

PDF file, 423K, Supplementary Figure S4 Cytostatic effects of WZ4002 and E7050 treatment.
Supplementary Figure 5 from MUC13 Mucin Augments Pancreatic Tumorigenesis
Authors: Chauhan Subhash C. , Ebeling Mara C. , Maher Diane M. , Koch Michael D. , Watanabe Akira , Aburatani Hiroyuki , Lio Yuhlong , Jaggi Meena
Published: April 2023

PDF file - 6.4MB
Supplementary Figure 2 from Immunotherapy for Hepatoma Using a Dual-Function Vector with Both Immunostimulatory and Pim-3–Silencing Effects
Authors: Guo Qie , Lan Peixiang , Yu Xin , Han Qiuju , Zhang Jian , Tian Zhigang , Zhang Cai
Published: April 2023

PDF - 159K, Figure S2. shRNA and bi-functional vector suppresses the expression of anti-apoptotic genes in hepatoma cells. A, The expressions of apoptosis-related genes Pim-3, Bcl-XL, Bcl-2, and Bim in Hepa1-6 cells were detected by RT-PCR and Western blotting. B, The expressions of Pim-3, Bad, and phospho-Bad were detected by Western blotting. The relative expression of pim-3 was normalized to that of beta-actin, and that of phospho-Bad to that of total Bad. C, Concentration of caspase-8 in cell lysates of Hepa1-6 after transfection for 24 h with the indicated vectors, as measured by ELISA. Data are representative or means (plus or minus) SD of three independent experiments. **, P ＜ 0.01, compared with the pSIREN transcription group.
Supplementary Figure 2 from HGF as a Circulating Biomarker of Onartuzumab Treatment in Patients with Advanced Solid Tumors
Authors: Penuel Elicia , Li Congfen , Parab Vaishali , Burton Luciana , Cowan Kyra J. , Merchant Mark , Yauch Robert L. , Patel Premal , Peterson Amy , Hampton Garret M. , Lackner Mark R. , Hegde Priti S.
Published: April 2023

PDF file - 24K, cHGF levels are stable over time and are not variable between screening (any time during visit -24 hours) and predose (Day 0).
Supplementary Materials and Methods from Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways
Authors: Aarts Marieke , Bajrami Ilirjana , Herrera-Abreu Maria T. , Elliott Richard , Brough Rachel , Ashworth Alan , Lord Christopher J. , Turner Nicholas C.
Published: April 2023

This file contains the Supplementary Materials and Methods.
Supplementary Figure Legend from Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma
Authors: Wu Man-si , Wang Guang-feng , Zhao Zhi-qiang , Liang Yi , Wang Heng-bang , Wu Miao-yi , Min Ping , Chen Li-zhen , Feng Qi-sheng , Bei Jin-xin , Zeng Yi-xin , Yang Dajun
Published: April 2023

PDF file - 23K
Supplementary Figures 1-4 from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth
Authors: Parnell K. Mark , Foulks Jason M. , Nix Rebecca N. , Clifford Adrianne , Bullough Jeremy , Luo Bai , Senina Anna , Vollmer David , Liu Jihua , McCarthy Virgil , Xu Yong , Saunders Michael , Liu Xiao-Hui , Pearce Scott , Wright Kevin , O'Reilly Marc , McCullar Michael V. , Ho Koc-Kan , Kanner Steven B.
Published: April 2023

Supplementary Figures 1-4 - PDF file 294K, Supplementary Figure 1: PKM2 activation by screening hit XC-409; Supplementary Figure 2: Phosphorylation state of PKM2 at Tyr105 in cancer cell lines; supplementary Figure 3: Viability of a selection of lung adenocarcinoma cells in media with and without serine; Supplementary Figure 4: Sensitivity of a panel of adherent cancer cell lines to serine deprivation and treatment with PKM2 activator SGI-10067
Supplementary Figure 3 from Comparing Histone Deacetylase Inhibitor Responses in Genetically Engineered Mouse Lung Cancer Models and a Window of Opportunity Trial in Patients with Lung Cancer
Authors: Ma Tian , Galimberti Fabrizio , Erkmen Cherie P. , Memoli Vincent , Chinyengetere Fadzai , Sempere Lorenzo , Beumer Jan H. , Anyang Bean N. , Nugent William , Johnstone David , Tsongalis Gregory J. , Kurie Jonathan M. , Li Hua , DiRenzo James , Guo Yongli , Freemantle Sarah J. , Dragnev Konstantin H. , Dmitrovsky Ethan
Published: April 2023

PDF file - 3079K, Supplemental Fig. 3: Paired pre-treatment versus post-vorinostat treatment biopsies from a lung cancer probed for p21 immunohistochemical expression. These representative biopsies from case 7 revealed an increase in p21 levels in the post-treatment (multiple arrows) relative to the pre-treatment lung cancer (single arrow) biopsy.
Supplementary Materials and Methods from BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast Cancer
Authors: Stone Andrew , Cowley Mark J. , Valdes-Mora Fatima , McCloy Rachael A. , Sergio C. Marcelo , Gallego-Ortega David , Caldon C. Elizabeth , Ormandy Christopher J. , Biankin Andrew V. , Gee Julia M.W. , Nicholson Robert I. , Print Cristin G. , Clark Susan J. , Musgrove Elizabeth A.
Published: April 2023

PDF - 51KB, PLK1 gene expression/survival analysis.
Supplementary Figure Legends from BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast Cancer
Authors: Stone Andrew , Cowley Mark J. , Valdes-Mora Fatima , McCloy Rachael A. , Sergio C. Marcelo , Gallego-Ortega David , Caldon C. Elizabeth , Ormandy Christopher J. , Biankin Andrew V. , Gee Julia M.W. , Nicholson Robert I. , Print Cristin G. , Clark Susan J. , Musgrove Elizabeth A.
Published: April 2023

PDF - 51KB
Supplementary Figure 2 from BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast Cancer
Authors: Stone Andrew , Cowley Mark J. , Valdes-Mora Fatima , McCloy Rachael A. , Sergio C. Marcelo , Gallego-Ortega David , Caldon C. Elizabeth , Ormandy Christopher J. , Biankin Andrew V. , Gee Julia M.W. , Nicholson Robert I. , Print Cristin G. , Clark Susan J. , Musgrove Elizabeth A.
Published: April 2023

PDF - 664KB, BCL-2 Gene expression vs methylation status.