bluuebunny/crossref_metadata_2025 huggingface dataset:
Daily Self-Monitoring of Symptoms and Skills Learning in Patients With Borderline Personality Disorder Through a Mobile Phone App: Protocol for a Pragmatic Randomized Controlled Trial (Preprint)
Authors: Helweg-Jørgensen Stig , Beck Lichtenstein Mia , Fruzzetti Alan E , Møller Dahl Christian , Pedersen Susanne S
Published: January 2020

BACKGROUND

Patient self-monitoring via mobile phones during psychotherapy can enhance and provide an overview of psychotherapeutic progress by graphically displaying current and previous symptom scores, providing feedback to the patient, delivering psychoeducative material, and providing timely data to the therapist or treatment team.

OBJECTIVE

This study will aim to assess the effects of using a mobile phone to self-monitor symptoms and acquire coping skills instead of using pen and paper during psychotherapy in patients with borderline personality disorder (BPD). Dialectical behavior therapy will be performed to treat BPD. The primary outcome is the mean time needed to learn coping skills directed at emotion regulation; the secondary outcome is changes in the BPD symptom score as measured by the Zanarini Rating Scale for Borderline Personality Disorder.

METHODS

This study is a pragmatic, multicenter randomized controlled trial. Participants were recruited through five public general psychiatric outpatient treatment facilities in Denmark. Patients are randomly assigned, on a 1:1 basis, to either the mobile phone condition (using the Monsenso mDiary mobile app) or pen-and-paper condition. Patients will complete several self-report questionnaires on symptom severity; assessments by trained raters on BPD severity will be performed as well. Survival analysis with a shared frailty model will be used to assess the primary outcome.

RESULTS

Recruitment began in June 2017 and was completed in February 2019 after 80 participants were recruited. The study ended in February 2020. It is expected that the benefits of mobile phone–based self-report compared to the pen-and-paper method will be demonstrated for skill learning speed and registration compliance. To our knowledge, this is the first trial exploring the impact of cloud-based mobile registration in BPD treatment.

CONCLUSIONS

This trial will report on the effectiveness of mobile phone–based self-monitoring during psychiatric treatment. It has the potential to contribute to evidence-based clinical practice since apps are already in use clinically.

CLINICALTRIAL

ClinicalTrials.gov NCT03191565; https://clinicaltrials.gov/ct2/show/NCT03191565

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/17737
Assessment of Psychological Distress in Adults With Type 2 Diabetes Mellitus Through Technologies: Literature Review (Preprint)
Authors: Bassi Giulia , Gabrielli Silvia , Donisi Valeria , Carbone Sara , Forti Stefano , Salcuni Silvia
Published: January 2020

BACKGROUND

The use of technological devices can support the self-management of individuals with type 2 diabetes mellitus (T2DM), particularly in addressing psychological distress. However, there is poor consistency in the literature regarding the use of psychological instruments for the web-based screening of patients’ psychological distress and subsequent monitoring of their psychological condition during digital interventions.

OBJECTIVE

This study aims to review previous literature on the types of psychological instruments delivered in digital interventions for assessing depression, anxiety, and stress in patients with T2DM.

METHODS

The literature review was conducted using the PsycINFO, CINAHL and PubMed databases, in which the following terms were considered: diabetes mellitus, measure, assessment, self-care, self-management, depression, anxiety, stress, technology, eHealth, mobile health, mobile phone, device, and smartphone.

RESULTS

In most studies, psychological assessments were administered on paper. A few studies deployed self-reporting techniques employing automated telephonic assessment, a call system for screening and monitoring patients’ conditions and preferences, or through telephone interviews via interactive voice response calls, a self-management support program leveraging tailored messages and structured emails. Other studies used simple telephone interviews and included the use of apps for tablets and smartphones to assess the psychological well-being of patients. Finally, some studies deployed mood rating scales delivered through tailored text message–based support systems.

CONCLUSIONS

The deployment of appropriate psychological tools in digital interventions allows researchers and clinicians to make the screening of anxiety, stress, and depression symptoms faster and easier in patients with T2DM. Data from this literature review suggest that mobile health solutions may be preferred tools to use in such digital interventions.

CLINICALTRIAL
Evidence Regarding Automatic Processing Computerized Tasks Designed For Health Interventions in Real-World Settings Among Adults: Systematic Scoping Review (Preprint)
Authors: Jayasinghe Harshani , Short Camille E , Braunack-Mayer Annette , Merkin Ashley , Hume Clare
Published: January 2020

BACKGROUND

Dual process theories propose that the brain uses 2 types of thinking to influence behavior: automatic processing and reflective processing. Automatic processing is fast, immediate, nonconscious, and unintentional, whereas reflective processing focuses on logical reasoning, and it is slow, step by step, and intentional. Most digital psychological health interventions tend to solely target the reflective system, although the automatic processing pathway can have strong influences on behavior. Laboratory-based research has highlighted that automatic processing tasks can create behavior change; however, there are substantial gaps in the field on the design, implementation, and delivery of automatic processing tasks in real-world settings. It is important to identify and summarize the existing literature in this area to inform the translation of laboratory-based research to real-world settings.

OBJECTIVE

This scoping review aims to explore the effectiveness of automatic training tasks, types of training tasks commonly used, mode of delivery, and impacts of gamification on automatic processing tasks designed for digital psychological health interventions in real-world settings among adults.

METHODS

The scoping review methodology proposed by Arskey and O’Malley and Colquhoun was applied. A scoping review was chosen because of the novelty of the digital automatic processing field and to encompass a broad review of the existing evidence base. Electronic databases and gray literature databases were searched with the search terms “automatic processing,” “computerised technologies,” “health intervention,” “real-world,” and “adults” and synonyms of these words. The search was up to date until September 2018. A manual search was also completed on the reference lists of the included studies.

RESULTS

A total of 14 studies met all inclusion criteria. There was a wide variety of health conditions targeted, with the most prevalent being alcohol abuse followed by social anxiety. Attention bias modification tasks were the most prevalent type of automatic processing task, and the majority of tasks were most commonly delivered over the web via a personal computer. Of the 14 studies included in the review, 8 demonstrated significant changes to automatic processes and 4 demonstrated significant behavioral changes as a result of changed automatic processes.

CONCLUSIONS

This is the first review to synthesize the evidence on automatic processing tasks in real-world settings targeting adults. This review has highlighted promising, albeit limited, research demonstrating that automatic processing tasks may be used effectively in a real-world setting to influence behavior change.
Comparing Classroom Instruction to Individual Instruction as an Approach to Teach Avatar-Based Patient Monitoring With Visual Patient: Simulation Study (Preprint)
Authors: Rössler Julian , Kaserer Alexander , Albiez Benjamin , Braun Julia , Breckwoldt Jan , Spahn Donat Rudolf , Nöthiger Christoph , Tscholl David Werner
Published: January 2020

BACKGROUND

Visual Patient is an avatar-based alternative to standard patient monitor displays that significantly improves the perception of vital signs. Implementation of this technology in larger organizations would require it to be teachable by brief class instruction to large groups of professionals. Therefore, our study aimed to investigate the efficacy of such a large-scale introduction to Visual Patient.

OBJECTIVE

In this study, we aimed to compare 2 different educational methods, one-on-one instruction and class instruction, for training anesthesia providers in avatar-based patient monitoring.

METHODS

We presented 42 anesthesia providers with 30 minutes of class instruction on Visual Patient (class instruction group). We further selected a historical sample of 16 participants from a previous study who each received individual instruction (individual instruction group). After the instruction, the participants were shown monitors with either conventional displays or Visual Patient displays and were asked to interpret vital signs. In the class instruction group, the participants were shown scenarios for either 3 or 10 seconds, and the numbers of correct perceptions with each technology were compared. Then, the teaching efficacy of the class instruction was compared with that of the individual instruction in the historical sample by 2-way mixed analysis of variance and mixed regression.

RESULTS

In the class instruction group, when participants were presented with the 3-second scenario, there was a statistically significant median increase in the number of perceived vital signs when the participants were shown the Visual Patient compared to when they were shown the conventional display (3 vital signs, P<.001; effect size –0.55). No significant difference was found for the 10-second scenarios. There was a statistically significant interaction between the teaching intervention and display technology in the number of perceived vital signs (P=.04; partial η2=.076). The mixed logistic regression model for correct vital sign perception yielded an odds ratio (OR) of 1.88 (95% CI 1.41-2.52; P<.001) for individual instruction compared to class instruction as well as an OR of 3.03 (95% CI 2.50-3.70; P<.001) for the Visual Patient compared to conventional monitoring.

CONCLUSIONS

Although individual instruction on Visual Patient is slightly more effective, class instruction is a viable teaching method; thus, large-scale introduction of health care providers to this novel technology is feasible.
Impact of self-designed Ningxin Anshen Decoction on the resting-state network functional connectivity in patients with mild to moderate generalized anxiety disorders: a Clinical Trial (Preprint)
Authors: He Wenjing , Xiong Hang , Fang Jiangshan , Gu Hao , Guo Rongjuan
Published: January 2020

BACKGROUND

Generalized anxiety disorder (GAD) is a persistent chronic excessive anxiety that is hard to control. Our previous study indicated that self-designed Ningxin Anshen Formula (NXAS) was effective to improve the symptoms and Hamilton anxiety scale (HAMA) of mild to moderate GAD patients.

OBJECTIVE

This study aimed to investigate the imapct of self-designed NXAS on the resting-state functional connectivity (RSFC) in patients with mild to moderate GAD and explore the potential mechanisms.

METHODS

A total of 61 patients diagnosed with mild to moderate GAD were recruited and divided into two groups: NXAS group (n=31) and placebo group (n=30). Before and after treatment, the RSFC was examined by resting-state functional MRI (rs-fMRI), the anxiety was assessed with HAMA, and the independent component analysis (ICA) was used to analyze the resting-state functional connectivity (RSFC). The correlation between HAMA score and abnormal RSFC was further evaluated.

RESULTS

The default mode network (DMN) showed evident RSFC interaction in the PCUN in both groups before and after therapy. The salience network (SN) showed obvious RSFC interaction in the bilateral gyrus frontalis inferiors and bilateral gyri temporalis superiors before and after therapy. In the NXAS group, the RSFC interction reduced significantly in the left gyrus frontalis inferior, but remained unchanged in the right gyrus frontalis inferior and bilateral gyri temporalis superiors after therapy. In the control group, the RSFC interaction increased dramatically after treatment. In addition, the abnormal RSFC had no relationship with HAMA score.

CONCLUSIONS

The self-designed NXAS can increase the RSFC in the PUCN on DMN and reduce RSFC in the orbIFG.L on SN to exert anti-anxiety effect.

CLINICALTRIAL

The study was registered on the Clinical Trials (NO. ChiCTR-OCC-12002329).
Editorial
Authors: Escala Miguel J.
Published: January 2020

No precisa resumen.
La diversidad en el aula: el desafío de interpretar la singularidad de los procesos de alfabetización inicial
Authors: O. Baez Mónica , D’Ottavio María Eugenia
Published: January 2020

La ley argentina Sobre Dificultades Específicas del Aprendizaje(Ley Nº 27.306, 2016) incluye entre sus principales puntos la dislexia como objeto de prevención y diagnóstico. Esto ha generado nuevos debates, así como el incremento de niños derivados a la consulta psicopedagógica desde las escuelas, con lo que se presenta el riesgo de una sobre-pato-logización de la población escolar, particularmente en el primer ciclo de la escolaridad primaria. Esto motivó este estudio cualitativo, basado en el marco interpretativo general de la epistemología y psicolingüística psicogené-tica, del que se da cuenta parcialmente en este artículo. Esta indagación se desarrolló en dos etapas: estudio de casos de niños derivados a atención psicopedagó-gica y exploración de las concepciones de una muestra de docentes. Los resultados manifiestan la importancia de la formación y de las intervenciones de los docentes para interpretar la normalidad de ciertas particularidades de los procesos de alfabetización.
Relaciones académicas y de género en docentes universitarios y su influencia en la publicación en revistas indexadas de alto impacto
Authors: Dillon Francisco , Espinosa Diana
Published: January 2020

Las concepciones de género, por lo general, son repro-ducidas a través de estereotipos y roles que dificultan el trabajo, más que nada a nivel universitario. En el caso de los docentes universitarios, este se ve reflejado parti-cularmente en la escasa participación multidisciplinaria, transdisciplinaria e interdisciplinaria en la autoría y coau-toría de artículos indexados en revistas de alto impacto. El objetivo de este estudio fue determinar la influencia de estas relaciones académicas y de género utilizando como marco metodológico la teoría de redes y de género en este tipo de publicaciones. La información utilizada para este análisis, corresponde al número de artículos escrito por docentes investigadores diferenciado por género. Como conclusión se menciona que, las medidas estadísticas de la red de comunicación académica y de género en docentes universitarios, influyen directamente en publicación de este tipo de artículos.
Алгебра рядов Дирихле моноида натуральных чисел
Authors: Добровольский Николай Николаевич , Добровольский Михаил Николаевич , Добровольский Николай Михайлович , Балаба Ирина Николаевна , Реброва Ирина Юрьевна
Published: January 2020

В работе для произвольного моноида натуральных чисел строятся основы алгебры рядов Дирихле либо над числовым полем, либо над кольцом целых чисел алгебраического числового поля.Для любого числового поля $$\mathbb{K}$$ показано, что множество $$\mathbb{D}^*(M)_{\mathbb{K}}$$ всех обратимых рядов Дирихле из $$\mathbb{D}(M)_{\mathbb{K}}$$ является бесконечной абелевой группой, состоящей из рядов, у которых первый коэффициент отличен от нуля.Вводится понятие целого ряда Дирихле моноида натуральных чисел, которые образуют алгебру над кольцом целых алгебраических чисел $$\mathbb{Z}_\mathbb{K}$$ алгебраического поля $$\mathbb{K}$$. Показано, что для группы $$\mathbb{U}_\mathbb{K}$$ алгебраических единиц кольца целых алгебраических чисел $$\mathbb{Z}_\mathbb{K}$$ алгебраического поля $$\mathbb{K}$$ множество $$\mathbb{D}(M)_{\mathbb{U}_\mathbb{K}}$$ целых рядов Дирихле, у которых $$a(1)\in\mathbb{U}_\mathbb{K}$$, является мультипликативной группой.Для любого ряда Дирихле из алгебры рядов Дирихле моноида натуральных чисел определены приведенный ряд, необратимая часть и дополнительный ряд. Найдена формула разложения произвольного ряда Дирихле в произведение приведенного ряда и конструкции из необратимой части и дополнительного ряда.Для любого моноида натуральных чисел выделена алгебра рядов Дирихле, сходящихся на всей комплексной области. Также построена алгебра рядов Дирихле с заданной полуплоскостью абсолютной сходимости. Показано, что для любого нетривиального моноида M и для любого вещественного $$\sigma_0$$ найдется бесконечное множество рядов Дирихле из $$\mathbb{D}(M)$$ таких, что областью их голоморфности является $$\alpha$$-полуплоскость $$\sigma>\sigma_0$$.С помощью теоремы универсальности С. М. Воронина удалось доказать слабую форму теоремы универсальности для широкого класса дзета-функций моноидов натуральных чисел.В заключении рассмотрены актуальные задачи с дзета-функциями моноидов натуральных чисел, требующие дальнейшего исследования. В частности, если верна гипотеза Линника-Ибрагимова, то для них должна быть справедлива и сильная теорема универсальности.
Об одном применении интеграла Дирихле
Authors: Гияси Азар
Published: January 2020

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Классические радикалы и центроид Мартиндейла артиновых и нётеровых алгебр Ли
Authors: Благовисная Анна Николаевна
Published: January 2020

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Борис Анатольевич Дубровин (некролог)
Authors: статья Редакционная
Published: January 2020

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RESUMOS DOS TRABALHOS APRESENTADOS NA V JORNADA DE QUÍMICA - CURSO DE BACHARELADO EM QUÍMICA DO IFRJ CAMPUS NILÓPOLIS
Authors: Autores Diversos
Published: January 2020

CADERNO DE RESUMOS
“ESCOVAR A HISTÓRIA A CONTRAPELO”: CONTRIBUIÇÕES DE WALTER BENJAMIN PARA A CONCEPÇÃO DIALÉTICA DA HISTÓRIA
Authors: Bemvindo Vitor
Published: January 2020

A atual conjuntura de avanço do pensamento conservador e reacionário em todo mundo, obriga os historiadores marxistas a recuperar a essência da concepção dialética da história sem esbarrar em certas interpretações simplistas, etapistas, evolucionistas ou positivistas do materialismo histórico e dialético. Em tempos de avanço do obscurantismo, “clarear essa obscuridade” “é a honra da pesquisa histórica”. Este artigo pretende recuperar o sentido dialético da concepção de história presente nas obras de Marx e Engels, a partir das contribuições do filósofo alemão Walter Benjamin. O estudo aqui proposto, pretende reconhecer, em especial, as elaborações em torno as ideias de “escovar a história a contrapelo” e de história aberta.
MEMÓRIAS DE MILITANTES: A GREVE DOS PETROLEIROS DE 1995
Authors: Lucena Carlos
Published: January 2020

Este artigo tem como objetivo analisar a greve dos petroleiros de 1995. Recupera os embates que construíram a greve, seu desenvolvimento e importância para a luta dos trabalhadores no Brasil. Demonstra as formas opressivas utilizadas pelo Governo Federal, o corpo diretivo da Petrobras e a mídia brasileira para desestabilizar o movimento paredista. Recupera as memórias dos petroleiros e sua compreensão sobre a maior greve dos anos 90 no Brasil.
FÁBRICAS DE INEQUIDAD: CRÍTICA DE LA ESCUELA CAPITALISTA
Authors: Baqué Juan Mainer
Published: January 2020

En este artículo abordamos desde una perspectiva histórica crítico-genealógica y de manera ensayística, el hecho de que los sistemas escolares del capitalismo, lejos de propiciar o fomentar la igualdad social, son un dispositivo eficaz para lograr la legitimación y consagración de la estructura de clases, el colonialismo y la segregación de género; todos ellos elementos consustanciales al desarrollo de esta formación socioeconómica.
ENCARCERAMENTO DAS MULHERES: TRABALHO, VIOLÊNCIA E ABANDONO
Authors: Alves Yara Elizabeth , Fidalgo Fernando Selmar Rocha
Published: January 2020

Este artigo é resultante de pesquisa e objetiva discutir um dos seus eixos temáticos: o encarceramento das mulheres, tanto pela relação capital-trabalho quanto propriamente nas unidades prisionais. A pesquisa foi realizada a partir de análise documental, observação e entrevistas semiestruturadas com 14 mulheres que cumpriam pena em unidades localizadas na Região Metropolitana de Belo Horizonte. Demonstra-se a coexistência das relações sociais de exploração econômica e de opressão sexual e evidencia-se que o modo de produção capitalista e o patriarcado combinam entre si e se reforçam mutuamente.
Structure and microstructure characterization of the La2SrB10O19 glass-ceramics
Authors: Stojanovic Jovica , Smiljanic Sonja , Grujic Snezana , Vulic Predrag , Matijasevic Srdjan , Nikolic Jelena , Savic Veljko
Published: January 2020

The crystal structure of new lanthanum strontium borate glass-ceramics was
refined by the Rietveld method. The results showed that La2SrB10O19 has the
monoclinic crystal structure, space group C2 (No. 5) with a = 11.1170(6), b
= 6.5667(3), c = 9.2363(3) ?, ? = 91.481?, V = 674.04(7) ?3, two formula
units per unit-cell, and density 3.830 g cm?3. The main building units of
the crystal structure are BO4 tetrahedra and BO3 triangles. Clusters
composed of [B5O12] form an infinite double layer running perpendicular to
the c-axis. Lanthanum atoms, situated in [B5O12]n layers, are coordinated
with 10 oxygen atom in a form of LaO10 polyhedra, while Sr atoms, located
between [B5O12]n layers, are coordinated with 8 oxygen atoms in a form of
SrO8 polyhedra. Microstructural measurements contain both crystallite domain
sizes and microstrain calculations obtained by the Warren-Averbach and the
simplified integral-breadth methods.
Sintering effect on electrical properties and morphology of lead-free Na0.92k0.08NbO3 ceramics
Authors: Kathait Gambheer , Panwar N.S. , Thapliyal Prashant , Biswas Don , Rohilla Vishal , Singh Surendra
Published: January 2020

Sodium potassium niobate (NKN) powders were synthesized by the solid-state
reaction method. The NKN ceramics for composition Na0.92K0.08NbO3 (NKN) were
then fabricated by a two-step sintering technique. The effects of the
two-step sintering on the properties of the ceramics were investigated. The
pure phase NKN was achieved for all sintering temperatures of 1100, 1150,
1200 and 1250?C. The observed change in the microstructure indicates that
the grain size increases with the increasing sintering temperatures. Also,
the two-step sintering technique produced a higher value of K/(K+Na)
weight-% ratio and peak dielectric constant for sintering temperatures 1100,
1150 and 1200?C. However, further increasing of the sintering temperatures
at 1250?C, reduces the K/(K+Na) weight-% ratio and the peak dielectric
constant (?c).
Lepenski Vir chronology and stratigraphy revisited
Authors: Boric Dusan
Published: January 2020

This article offers a new look at the stratigraphy and chronology of
Mesolithic and Neolithic deposits at Lepenski Vir, particularly based on
newly available Accelerator Mass Spectrometry (AMS) dating and aDNA genomic
evidence. It focuses on a detailed analysis of several key contexts for
which new radiocarbon dates are available while at the same time reviewing
taphonomic and age-offset problems when dating human remains and other
materials affected by the aquatic reservoir effect in the Danube Gorges
area. The robust chronological evidence as well as available stratigraphic
data overwhelmingly show that the start of the main and iconic phase of the
occupation of this site, represented by the architecture of trapezoidal
buildings and sculpted sandstone boulders, should unequivocally be dated to
the period of the Mesolithic-Neolithic transition in the last two centuries
of the seventh millennium cal BC. At this time, local forager populations of
distinct hunter-gatherer genetic ancestry came into contact and mixed with
incoming Neolithic, farming populations of north-western Anatolian genetic
ancestry, based on the available genomic data but also supported by studies
of material culture traditions. The article deals directly with the recent
criticism of this chrono-stratigraphic model for Lepenski Vir.
Building with octagon from the locality of „Gradsko polje” in Nis (Naissus). New archaeological excavations
Authors: Gavrilovic-Vitas Nadezda , Milosevic-Jevtic Gordana
Published: January 2020

After three decades of exploring and excavating the so-called building with
octagon at the locality of ?Gradsko polje? in Nis, new archaeological
research has been conducted. The main goal of the new excavations was, based
on a previously led geophysical survey, to determine the dimensions of the
western part of the building and to continue the exploration of the approach
in front of the room with octagon. Despite modest finances and the short
duration of the excavations, this year?s archaeological research has allowed
us to conclude that the building with octagon had at least three building
phases, starting with the beginning of the 4th century and was in use until
the 6th century. Also, a clear stratum of Middle Age houses, dating to the
11th-12th century, was also confirmed in this year?s excavations, along with
many fragments of ceramics belonging to the same period. This paper
discusses in detail the archaeological and architectural results obtained
from the new excavations led in 2018.
Lead seals with tetrarchic busts from the imperial palace in Sirmium
Authors: Popovic Ivana
Published: January 2020

In the course of archaeological excavations of the north section of the
imperial palace in Sirmium (locality 85), conducted in 2015, as many as 39
lead seals were found to the south of column IV of the polygonal structure
encountered in 2014. Nine specimens of imperial seals with a representation
of four busts, i.e. images of the tetrarchs, are particularly interesting in
this group. These seals appear in three iconographic variants (a-c)
depending on whether the four busts are positioned in two rows or in a
single row and whether they are of identical size. The discovery of imperial
lead seals with the busts of tetrarchs bears witness to the importance of
Sirmium at the time of the tetrarchy, not only as an army base for
Diocletian?s wars against the Sarmatians, but also as a commercial centre
where the deliveries of various products also arrived. They were, among
other things, intended for building and decorating the polygonal structure
used for celebrating the imperial cult.
The stat us of the coloni in the mining district of Vipasca in view of the provisions of the Lex metallis dicta
Authors: Maricic Gordan , Sajin Zeljka
Published: January 2020

This paper discusses changes in the Roman mining policy that took place
during the Empire, based on the provisions found on the second tablet of the
Lex metallis dicta2 (Vip II, 1, 2,5,6,7,8,9) from Vipasca. The main stress
is placed on the position, rights and obligations of the coloni and miners
and the status of mining pits after their sale. By examining the efficiency
of the indirect model of silver and lead exploitation in the mining district
of Vipasca, the authors present their solution to the unresolved issue of
the means by which the Roman state obtained large quantities of metals
necessary for the operation of state-run factories and imperial mints.
The outer forts of Caricin grad: Visualisation of digital terrain models and interpretation
Authors: Ivanisevic Vujadin , Bugarski Ivan , Stamenkovic Aleksandar
Published: January 2020

The erection of a new polis, Justiniana Prima, on the site of Caricin Grad,
was part of a larger engineering project in a rural hilly setting of the
western areas of Dacia Mediterranea, which had also included the
construction of nearby fortlets. The article presents LiDAR data which has
provided new information related to their ground-plan and dimensions.
Located in a 12 km? area around the metropolis, St Elias, Kuliste-Jezero and
Gornje Gradiste in Svinjarica were LiDAR scanned in 2011, while the Sekicol
fort, with its 4 km? surroundings, was subjected to the same technology in
2015. Our analysis of the outer fortifications of Justiniana Prima is based
on a visualisation of the obtained digital terrain models and field
observations; in the case of the St Elias fort, we also used the results of
the 1976 excavations. These fortlets had manifold functions. On the one
hand, they overlooked the approaches to the city and its infrastructure -
Kuliste-Jezero was a watchtower - and on the other, they also served as
shelters for the local population - refugia. In the middle of the St Elias
fort there was a large three-nave church; this may well have been a
fortified monastery. Future research of these forts should provide more
detailed information on their chronology and function, complement the
outstanding results of the LiDAR and geophysical surveys, and contribute to
a better understanding of Justiniana Prima itself.
Abnormal data acquisition system of mechanical operation based on block chain technology
Authors: Xiao Yinyin
Published: January 2020

In order to solve the problems of information sharing, tampering and leaking in mechanical operation data acquisition, an abnormal data acquisition system for mechanical operation based on block chain technology was designed. The system takes Beihang Chain as the prototype and designs the overall architecture of the system. Data acquisition module uses data acquisition card, CPU, programmable logic device, A/D conversion chip and other equipment to collect and process abnormal data in mechanical operation. The alarm module divides the abnormal data collected by the data acquisition module into five levels: P1-P5. After the implementation of the alarm module, the abnormal information and alarm information in the process of mechanical operation are transmitted to the abnormal data management module for storage. The system adopts the method of mechanical operation anomaly data acquisition based on sparse sampling, and adopts hierarchical clustering method to establish the data acquisition tree of mechanical operation anomaly. The block chain technology is used to design the process of storing and monitoring abnormal data of mechanical operation. The experimental results show that the system has high accuracy of fitting curve for abnormal data acquisition, low real-time energy consumption, and the minimum energy consumption is only 0.01/10-3 J.
Mechanical grinding method of multi-axis linkage for elliptic contour based on algebraic geometry
Authors: Li Li
Published: January 2020

Aiming at the shortcomings of traditional elliptic contour grinding methods, such as large grinding roughness and poor contour accuracy, a multi-axis mechanical grinding method based on algebraic geometry is proposed. This method studies the first attempt of elliptic contour. The process includes selecting suitable multi-axis grinding tools and selecting appropriate grinding methods according to grinding process. Using specific workpieces, grinding path planning, motion attitude determination and error compensation based on algebraic geometry for multi-axis mechanical grinding are carried out. The results show that compared with the traditional grinding method, the device has the smallest surface roughness, the contour radian is closer to the expected results, and has higher performance, which solves the grinding defects.
PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid
Authors: Morieri Mario Luca , Shah Hetal S. , Sjaarda Jennifer , Lenzini Petra A. , Campbell Hannah , Motsinger-Reif Alison A. , Gao He , Lovato Laura , Prudente Sabrina , Pandolfi Assunta , Pezzolesi Marcus G. , Sigal Ronald J. , Paré Guillaume , Marcovina Santica M. , Rotroff Daniel M. , Patorno Elisabetta , Mercuri Luana , Trischitta Vincenzo , Chew Emily Y. , Kraft Peter , Buse John B. , Wagner Michael J. , Cresci Sharon , Gerstein Hertzel C. , Ginsberg Henry N. , Mychaleckyj Josyf C. , Doria Alessandro
Published: January 2020

The cardiovascular benefits of fibrates have been shown to be heterogeneous and to depend on the presence of atherogenic dyslipidemia. We investigated whether genetic variability in the PPARA gene, coding for the pharmacological target of fibrates (PPAR-α), could be used to improve the selection of patients with type 2 diabetes who may derive cardiovascular benefit from addition of this treatment to statins. We identified a common variant at the PPARA locus (rs6008845, C/T) displaying a study-wide significant influence on the effect of fenofibrate on major cardiovascular events (MACE) among 3,065 self-reported white subjects treated with simvastatin and randomized to fenofibrate or placebo in the ACCORD-Lipid trial. T/T homozygotes (36% of participants) experienced a 51% MACE reduction in response to fenofibrate (hazard ratio 0.49; 95% CI 0.34–0.72), whereas no benefit was observed for other genotypes (Pinteraction = 3.7 × 10−4). The rs6008845-by-fenofibrate interaction on MACE was replicated in African Americans from ACCORD (N = 585, P = 0.02) and in external cohorts (ACCORD-BP, ORIGIN, and TRIUMPH, total N = 3059, P = 0.005). Remarkably, rs6008845 T/T homozygotes experienced a cardiovascular benefit from fibrate even in the absence of atherogenic dyslipidemia. Among these individuals, but not among carriers of other genotypes, fenofibrate treatment was associated with lower circulating levels of CCL11—a proinflammatory and atherogenic chemokine also known as eotaxin (P for rs6008845-by-fenofibrate interaction = 0.003). The GTEx data set revealed regulatory functions of rs6008845 on PPARA expression in many tissues. In summary, we have found a common PPARA regulatory variant that influences the cardiovascular effects of fenofibrate and that could be used to identify patients with type 2 diabetes who would derive benefit from fenofibrate treatment, in addition to those with atherogenic dyslipidemia.
Troponin T Parallels Structural Nerve Damage in Type 2 Diabetes: A Cross-sectional Study Using Magnetic Resonance Neurography
Authors: Jende Johann M.E. , Groener Jan B. , Kender Zoltan , Hahn Artur , Morgenstern Jakob , Heiland Sabine , Nawroth Peter P. , Bendszus Martin , Kopf Stefan , Kurz Felix T.
Published: January 2020

Clinical studies have suggested that changes in peripheral nerve microcirculation may contribute to nerve damage in diabetic polyneuropathy (DN). High-sensitivity troponin T (hsTNT) assays have been recently shown to provide predictive values for both cardiac and peripheral microangiopathy in type 2 diabetes (T2D). This study investigated the association of sciatic nerve structural damage in 3 Tesla (3T) magnetic resonance neurography (MRN) with hsTNT and N-terminal pro-brain natriuretic peptide serum levels in patients with T2D. MRN at 3T was performed in 51 patients with T2D (23 without DN, 28 with DN) and 10 control subjects without diabetes. The sciatic nerve’s fractional anisotropy (FA), a marker of structural nerve integrity, was correlated with clinical, electrophysiological, and serological data. In patients with T2D, hsTNT showed a negative correlation with the sciatic nerve’s FA (r = −0.52, P < 0.001), with a closer correlation in DN patients (r = −0.66, P < 0.001). hsTNT further correlated positively with the neuropathy disability score (r = 0.39, P = 0.005). Negative correlations were found with sural nerve conduction velocities (NCVs) (r = −0.65, P < 0.001) and tibial NCVs (r = −0.44, P = 0.002) and amplitudes (r = −0.53, P < 0.001). This study is the first to show that hsTNT is a potential indicator for structural nerve damage in T2D. Our results indirectly support the hypothesis that microangiopathy contributes to structural nerve damage in T2D.
Late Relapse of Diabetes After Bariatric Surgery: Not Rare, but Not a Failure
Authors: Aminian Ali , Vidal Josep , Salminen Paulina , Still Christopher D. , Nor Hanipah Zubaidah , Sharma Gautam , Tu Chao , Wood G. Craig , Ibarzabal Ainitze , Jimenez Amanda , Brethauer Stacy A. , Schauer Philip R. , Mahawar Kamal
Published: January 2020

OBJECTIVE

To characterize the status of cardiometabolic risk factors after late relapse of type 2 diabetes mellitus (T2DM) and to identify factors predicting relapse after initial diabetes remission following bariatric surgery to construct prediction models for clinical practice.

RESEARCH DESIGN AND METHODS

Outcomes of 736 patients with T2DM who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) at an academic center (2004–2012) and had ≥5 years’ glycemic follow-up were assessed. Of 736 patients, 425 (58%) experienced diabetes remission (HbA1c <6.5% [48 mmol/mol] with patients off medications) in the 1st year after surgery. These 425 patients were followed for a median of 8 years (range 5–14) to characterize late relapse of diabetes.

RESULTS

In 136 (32%) patients who experienced late relapse, a statistically significant improvement in glycemic control, number of diabetes medications including insulin use, blood pressure, and lipid profile was still observed at long-term. Independent baseline predictors of late relapse were preoperative number of diabetes medications, duration of T2DM before surgery, and SG versus RYGB. Furthermore, patients who relapsed lost less weight during the 1st year after surgery and regained more weight afterward. Prediction models were constructed and externally validated.

CONCLUSIONS

While late relapse of T2DM is a real phenomenon (one-third of our cohort), it should not be considered a failure, as the trajectory of the disease and its related cardiometabolic risk factors is changed favorably after bariatric surgery. Earlier surgical intervention, RYGB (compared with SG) and more weight loss (less late weight regain) are associated with less diabetes relapse in the long-term.
A Novel Dual-Hormone Insulin-and-Pramlintide Artificial Pancreas for Type 1 Diabetes: A Randomized Controlled Crossover Trial
Authors: Haidar Ahmad , Tsoukas Michael A. , Bernier-Twardy Sarah , Yale Jean-Francois , Rutkowski Joanna , Bossy Anne , Pytka Evelyne , El Fathi Anas , Strauss Natalia , Legault Laurent
Published: January 2020

OBJECTIVE

The rapid insulin-alone artificial pancreas improves glycemia in type 1 diabetes but daytime control remains suboptimal. We propose two novel dual-hormone artificial pancreas systems.

RESEARCH DESIGN AND METHODS

We conducted a randomized crossover trial comparing a rapid insulin-alone artificial pancreas with rapid insulin-and-pramlintide and with regular insulin-and-pramlintide artificial pancreas systems in adults with type 1 diabetes. Participants were assigned to the interventions in random order during three 24-h inpatient visits. Each visit was preceded by an outpatient hormonal open-loop run-in period of 10–14 days. The dual-hormone artificial pancreas delivered pramlintide in a basal-bolus manner, using a novel dosing algorithm, with a fixed ratio relative to insulin. The primary outcome was time in the range 3.9–10.0 mmol/L.

RESULTS

Compared with the rapid insulin-alone artificial pancreas system, the rapid insulin-and-pramlintide system increased the time in range from 74% (SD 18%) to 84% (13%) (P = 0.0014), whereas the regular insulin-and-pramlintide system did not change the time in range (69% [19%]; P = 0.22). The increased time in range with the rapid insulin-and-pramlintide system was due to improved daytime control (daytime time in range increased from 63% [23%] to 78% [16%], P = 0.0004). There were 11 (1 per 2.5 days) hypoglycemic events (<3.3 mmol/L with symptoms or <3.0 mmol/L irrespective of symptoms) with the rapid insulin-alone system, compared with 12 (1 per 2.3 days) and 18 (1 per 1.4 days) with the rapid and regular insulin-and-pramlintide systems, respectively. Gastrointestinal symptoms were reported after 0% (0 of 112) of meals with the rapid insulin-alone system, compared with 6% (6 of 108) and 11% (11 of 104) with the rapid and regular insulin-and-pramlintide systems, respectively; none of the symptoms were severe.

CONCLUSIONS

A novel rapid insulin-and-pramlintide artificial pancreas improves glucose control compared with a rapid insulin-alone artificial pancreas (ClinicalTrials.gov number NCT02814123).
Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance
Authors: Succurro Elena , Pedace Elisabetta , Andreozzi Francesco , Papa Annalisa , Vizza Patrizia , Fiorentino Teresa Vanessa , Perticone Francesco , Veltri Pierangelo , Cascini Giuseppe Lucio , Sesti Giorgio
Published: January 2020

OBJECTIVE

Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study.

RESEARCH DESIGN AND METHODS

The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10).

RESULTS

After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = −0.422; P = 0.025) and 2-h (r = −0.374; P = 0.05) postload glucose levels, but not with fasting glucose.

CONCLUSIONS

This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high.
Complications of Antenatal Corticosteroids in Infants Born by Early Term Scheduled Cesarean Section
Authors: Gupta Katharine , Rajagopal Rohit , King Felicia , Simmons David
Published: January 2020

OBJECTIVE

To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration.

RESEARCH DESIGN AND METHODS

In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia.

RESULTS

NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, P = 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, P = 0.209) following corticosteroid administration.

CONCLUSIONS

Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.
Messianic movements and the sacralization of the territory
Authors: Pace Vincenzo
Published: January 2020

This article focuses on contemporary Messianic Judaism. The author deals particularly with the Chabad and Gush Emunim movements, which have established many settlements in the West Bank, Sinai Peninsula, Gaza Strip, and Golan Heights. These settlements not only satisfy a vital need for living space but are also the expression of strong Messianic tension. This tension produces a mundus imaginalis (Corbin), the boundaries of which come between heaven and earth, between the biblical contours of the Promised Land and the harsh reality of a territory marked by war. The object of analysis is the toponymic politics developed by these Messianic movements in order to sacralize the territory in view of the coming of the Messiah.
Territórios, mobilidade e biografia no espiritismo franco-brasileiro
Authors: Teixeira Gismair Martins
Published: January 2020

O presente artigo pretende apresentar um estudo sobre a territorialidade do espiritismo franco-brasileiro. O conceito de territorialidade adotado para este trabalho é o elaborado pelos pensadores franceses Gilles Deleuze e Félix Guattari na obra Mil platôs: capitalismo e esquizofrenia 2. Em ambos os autores, a territorialidade aparece como um vetor de fluxo do conceito de rizoma, que é basilar na estruturação de conteúdo desta obra. Inerente à ideia de territorialidade é a noção de mobilidade. Neste trabalho, esses marcadores conceituais serão aplicados ao estudo de caso em torno da trajetória do médium Divaldo Pereira Franco, representativa figura do espiritismo franco-brasileiro, cujos dados biográficos servirão de análise da mobilidade territorial do espiritismo codificado na França por Allan Kardec.
ESPIRITUALIDADE DO DESERTO: UMA PROPOSTA MODERNA PARA UMA ESPIRITUALIDADE DE EXÍLIO E ENCONTRO
Authors: França Cícero Alves
Published: January 2020

O presente artigo quer ser uma contribuição da Teologia da Espiritualidade aos questionamentos hodiernos sobre a escassez de sentido e efemeridade do tempo presente, propondo a espiritualidade do deserto como caminho de solidão, silêncio e oração. A solidão nos mostra o caminho para deixar que nosso comportamento seja moldado não por nossas compulsões, mas por nossa nova mente: a de Cristo. O silêncio nos impede de ser sufocados por nosso mundo repleto de palavras vãs e nos ensina a falar a Palavra de Deus. Por fim, a oração dá à solidão e ao silêncio uma realidade concreta, um solo fértil em que possam florescer. Essa é uma oração capaz de ser realizada com a mente ao coração. Assim, entramos no “coração de Deus”, que abraça toda a história com seu amor eternamente criador.
EVOLUÇÃO E DOUTRINA DA SALVAÇÃO
Authors: De Souza Josiney Alves
Published: January 2020

Baseada nas suposições da teoria evolucionária, a teologia da natureza reinterpreta a cosmovisão cristã e atribui sentido diverso para entendimentos bíblicos tradicionais de Criação, livre arbítrio, pecado, queda e redenção. O presente manuscrito analisa como essas variações de sentido afetam a concepção bíblica de salvação. Verifica-se que a evolução plena do homem é inconcebível pela trivialidade do mecanismo darwiniano, cuja superestimada aplicação compreende uma ação divina restringida ao mero acompanhamento interior e solidário ao sofrimento humano. Nesses aspectos, fica descaracterizada a intervenção divina para a salvação imediata. É também demonstrado que as Escrituras Sagradas contêm uma exposição própria sobre a evolução corpóreo-espiritual do homem, sendo, assim, definitivamente desnecessário o apelo ao paradigma darwiniano. Pelo contrário, deduz-se que as variações nas concepções cristãs são frutos da mudança nos alicerces do pensamento, cuja extrapolação abre caminho para heresias.
O CONHECIMENTO DE SI NO ITINERÁRIO ESPIRITUAL DE ORÍGENES DE ALEXANDRIA
Authors: Gomes Ribeiro Francisco Erlânio
Published: January 2020

A famosa inscrição do oráculo de Delfos “conhece-te a ti mesmo” está presente ao longo da história do pensamento filosófico e da espiritualidade cristã. No Agradecimento a Orígenes, Gregório Taumaturgo apresenta o mestre como um verdadeiro filósofo. Segundo aprendeu do mestre, a excelência do filosofar encontra-se na realização do dito oracular “conhece-te a ti mesmo”. Este artigo pretende desenvolver esse aspecto do itinerário espiritual de Orígenes a partir de passagens de seu Comentário ao Cântico dos Cânticos, no qual o autoconhecimento está posto no reconhecimento do ser criado à imagem e semelhança de Deus (campo ontológico) e no conhecimento das disposições da alma (campo ético).