bluuebunny/crossref_metadata_2025 huggingface dataset:
Sparse principal component regression via singular value decomposition approach
Authors: Kawano Shuichi
Published: February 2021

Principal component regression (PCR) is a two-stage procedure: the first stage performs principal component analysis (PCA) and the second stage builds a regression model whose explanatory variables are the principal components obtained in the first stage. Since PCA is performed using only explanatory variables, the principal components have no information about the response variable. To address this problem, we present a one-stage procedure for PCR based on a singular value decomposition approach. Our approach is based upon two loss functions, which are a regression loss and a PCA loss from the singular value decomposition, with sparse regularization. The proposed method enables us to obtain principal component loadings that include information about both explanatory variables and a response variable. An estimation algorithm is developed by using the alternating direction method of multipliers. We conduct numerical studies to show the effectiveness of the proposed method.
Modeling Fused Filament Fabrication using Artificial Neural Networks
Authors: Oehlmann Paul , Osswald Paul , Blanco Juan Camilo , Friedrich Martin , Rietzel Dominik , Witt Gerd
Published: February 2021

With industries pushing towards digitalized production, adaption to expectations and increasing requirements for modern applications, has brought additive manufacturing (AM) to the forefront of Industry 4.0. In fact, AM is a main accelerator for digital production with its possibilities in structural design, such as topology optimization, production flexibility, customization, product development, to name a few. Fused Filament Fabrication (FFF) is a widespread and practical tool for rapid prototyping that also demonstrates the importance of AM technologies through its accessibility to the general public by creating cost effective desktop solutions. An increasing integration of systems in an intelligent production environment also enables the generation of large-scale data to be used for process monitoring and process control. Deep learning as a form of artificial intelligence (AI) and more specifically, a method of machine learning (ML) is ideal for handling big data. This study uses a trained artificial neural network (ANN) model as a digital shadow to predict the force within the nozzle of an FFF printer using filament speed and nozzle temperatures as input data. After the ANN model was tested using data from a theoretical model it was implemented to predict the behavior using real-time printer data. For this purpose, an FFF printer was equipped with sensors that collect real time printer data during the printing process. The ANN model reflected the kinematics of melting and flow predicted by models currently available for various speeds of printing. The model allows for a deeper understanding of the influencing process parameters which ultimately results in the determination of the optimum combination of process speed and print quality.
Towards innovative road cycle gloves for low vibration transmission
Authors: Sanseverino G. , Schwanitz S. , Krumm D. , Odenwald S. , Lanzotti A.
Published: February 2021

This research activity aims to develop new cycling gloves. A first step was focused on the definition of the functional requirements through user centred design methods. Since vibrations coming to the hand-arm system of a cyclist have a considerable effect a second step was concentrated on the analysis of hand-arm vibrations in road cycling. The paper shows results of laboratory tests executed for three different hand sizes, three different frequency ranges, with two different type of gloves and without gloves. Load conditions used for the test were determined with a former field test. Results obtained were analysed using Analysis of Variance (ANOVA), that showed no significant effect of existing gloves in reducing vibration transmissibility. This led to the need of new kind of cycling gloves that could reduce those vibrations and increase the cyclist’s comfort.
Psychometric properties of the polish updated Illinois rape myth acceptance scale
Authors: Łyś Agnieszka Ewa , Bargiel-Matusiewicz Kamilla , Krasuski Tomasz , Studzińska Anna
Published: February 2021

Stereotyped beliefs concerning rape, called rape myths, are a global problem. The aim of the studies was to assess the psychometric properties of the Polish version of the Updated Illinois Rape Myth Acceptance Scale which is used to assess rape myth acceptance. The tool has a high internal consistency (α = .92) and an overly good test-retest reliability (the It Wasn’t Really Rape subscale being one exception), The five-factor model fits the data better than the four-factor one. Both in the case of the four-factor and the five-factor models the brief version fits the data better than the full one. The study also demonstrated positive correlations of rape myth acceptance with right-wing authoritarianism, social dominance orientation, system justification, cultural conservatism, hostile sexism, benevolent sexism, beliefs in biological origins of the differences between men and women and unjust world beliefs. The correlation between rape myth acceptance and beliefs in cultural origins of the differences between men and women was negative. The analyses suggest that the Polish Updated Illinois Rape Myth Acceptance Scale is a reliable and valid tool and can be useful for further studies of rape myth acceptance.
Investigation of flue gas water-alternating gas (flue gas–WAG) injection for enhanced oil recovery and multicomponent flue gas storage in the post-waterflooding reservoir
Authors: Wang Zhou-Hua , Sun Bo-Wen , Guo Ping , Wang Shuo-Shi , Liu Huang , Liu Yong , Zhou Dai-Yu , Zhou Bo
Published: February 2021

Flue gas flooding is one of the important technologies to improve oil recovery and achieve greenhouse gas storage. In order to study multicomponent flue gas storage capacity and enhanced oil recovery (EOR) performance of flue gas water-alternating gas (flue gas–WAG) injection after continuous waterflooding in an oil reservoir, a long core flooding system was built. The experimental results showed that the oil recovery factor of flue gas–WAG flooding was increased by 21.25% after continuous waterflooding and flue gas–WAG flooding could further enhance oil recovery and reduce water cut significantly. A novel material balance model based on storage mechanism was developed to estimate the multicomponent flue gas storage capacity and storage capacity of each component of flue gas in reservoir oil, water and as free gas in the post-waterflooding reservoir. The ultimate storage ratio of flue gas is 16% in the flue gas–WAG flooding process. The calculation results of flue gas storage capacity showed that the injection gas storage capacity mainly consists of N2 and CO2, only N2 exists as free gas phase in cores, and other components of injection gas are dissolved in oil and water. Finally, injection strategies from three perspectives for flue gas storage, EOR, and combination of flue gas storage and EOR were proposed, respectively.
Sampling the Flow of a Bandlimited Function
Authors: Aldroubi Akram , Gröchenig Karlheinz , Huang Longxiu , Jaming Philippe , Krishtal Ilya , Romero José Luis
Published: February 2021

We analyze the problem of reconstruction of a bandlimited function f from the space–time samples of its states $$f_t=\phi _t*f$$

f
t

=

ϕ
t

∗
f

resulting from the convolution with a kernel $$\phi _t$$

ϕ
t

. It is well-known that, in natural phenomena, uniform space–time samples of f are not sufficient to reconstruct f in a stable way. To enable stable reconstruction, a space–time sampling with periodic nonuniformly spaced samples must be used as was shown by Lu and Vetterli. We show that the stability of reconstruction, as measured by a condition number, controls the maximal gap between the spacial samples. We provide a quantitative statement of this result. In addition, instead of irregular space–time samples, we show that uniform dynamical samples at sub-Nyquist spatial rate allow one to stably reconstruct the function $$\widehat{f}$$

f
^

away from certain, explicitly described blind spots. We also consider several classes of finite dimensional subsets of bandlimited functions in which the stable reconstruction is possible, even inside the blind spots. We obtain quantitative estimates for it using Remez-Turán type inequalities. En route, we obtain Remez-Turán inequality for prolate spheroidal wave functions. To illustrate our results, we present some numerics and explicit estimates for the heat flow problem.
What the COVID-19 Pandemic Reveals about Racial Differences in Child Welfare and Child Well-Being: An Introduction to the Special Issue
Authors: Parolin Zachary
Published: February 2021

This paper introduces the special issue on race, child welfare, and child well-being. In doing so, I summarize the evidence of racial/ethnic disparities in child well-being after the onset of the COVID-19 pandemic. Recent findings demonstrate that, compared to white children, black and Latino children are more likely to have experienced poverty and food insufficiency, to have had parents lose their jobs, and to be exposed to distance learning and school closures during the pandemic. I argue that though COVID-19 has indeed worsened racial/ethnic disparities in child well-being, it has also served to place a spotlight on the American welfare state’s historical mistreatment of low-income families and black and Latino families in particular. Consider that around three-fourths of black and Latino children facing food insufficiency during the pandemic also experienced food insufficiency prior to the onset of the pandemic. Moving forward, analyses of racial/ethnic disparities in child well-being during the pandemic, I argue, must not only consider the economic shock and high unemployment rates of 2020, but the failure of the American welfare state to adequately support jobless parents, and black and Latino parents in particular, long before the COVID-19 pandemic arrived.
Coupling of diagenetic alterations and mechanical properties of Lower Permian siliciclastic sandstones: a pilot study
Authors: Monsees Alexander C. , Biebricher Sven F. , Busch Benjamin , Feinendegen Martin , Ziegler Martin , Hilgers Christoph
Published: February 2021

Initial detrital composition and authigenic alterations during diagenesis of three sandstone types are related to their mechanical properties. Sandstones were prepared for geotechnical standard tests [density, uniaxial compressive strength (UCS), Young’s modulus (E), strain at failure (ε)] and thin sections for petrographic analyses (point counting). UCS ranges from 3 to 62 MPa and positively correlates with density (1.75–2.35 g/cm3) and E (0.3–12.7 GPa). Optical porosity is controlling these mechanical parameters and was linked to diagenetic alterations. Diagenetic alterations affecting porosity reduction are the abundance of clay minerals, and the intensity of mechanical and chemical compaction. The latter is controlled by clay mineral coatings on contacts between detrital grains, and the occurrence of authigenic quartz and dolomite. Horizontal contact lengths of grains normalized to their respective particle diameter (effective contact ratio, ECR) and porosity are identified as a control on the mechanical properties UCS and E, reflected by the rock strength index SR. The results of this pilot study suggest that SR is able to predict UCS and E based on petrographic information obtained from the studied samples. These results enhance the understanding of the coupling between mineralogy and geomechanics and highlight the impact of diagenesis on geomechanical behavior.
Japanese multicenter registry evaluating the antegrade dissection reentry with cardiac computerized tomography for chronic coronary total occlusion
Authors: Habara Maoto , Tsuchikane Etsuo , Shimizu Kazuki , Kashima Yoshifumi , Shimoji Kenichiro , Nakamura Shigeru , Niizeki Takeshi , Tsutsumi Takaki , Ito Yoshiaki , Kawasaki Tomohiro ,   for the Bridge point Club Japan
Published: February 2021

Recently, antegrade dissection re-entry (ADR) with re-entry device for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has evolved to become one of the pillar techniques of the hybrid algorithm. Although the success rate of the device is high, it could be improved. We sought to evaluate the current trends and issues associated with ADR in Japan and evaluate the potential of cardiac computed tomography angiography (CCTA) for ADR procedure. A total 48 patients with CTO suitable for ADR evaluated by baseline conventional angiography and CCTA were enrolled. Procedural success and technical success were evaluated as the primary and secondary observations. Furthermore, all puncture points were analyzed by CCTA. CT score at each punctured site depended on the location of plaque deposition (none; + 0, at isolated myocardial site; + 1, at epicardial site; + 2) and the presence of calcification (none; + 0, presence; + 1) was analyzed and calculated (score 0–3). Overall procedure success rate was 95.8%. Thirty-two cases were attempted with the ADR procedure and 25 cases of them were successful. The technical success rate was 78.1% and myocardial infarction or other major complications were not observed in any cases. CT score at 60 puncture sites in 32 cases were analyzed and the score at technical success points was significantly smaller compared to that at technical failure points (0.68 ± 1.09 vs 1.77 ± 1.09, p < 0.0001). CTO-PCI with Stingray device in Japan could achieve a high procedure success and technical success rate. Pre procedure cardiac CT evaluation might support ADR procedure for appropriate patient selection or puncture site selection.
Evaluating Explainability Methods Intended for Multiple Stakeholders
Authors: Martin Kyle , Liret Anne , Wiratunga Nirmalie , Owusu Gilbert , Kern Mathias
Published: February 2021

Explanation mechanisms for intelligent systems are typically designed to respond to specific user needs, yet in practice these systems tend to have a wide variety of users. This can present a challenge to organisations looking to satisfy the explanation needs of different groups using an individual system. In this paper we present an explainability framework formed of a catalogue of explanation methods, and designed to integrate with a range of projects within a telecommunications organisation. Explainability methods are split into low-level explanations and high-level explanations for increasing levels of contextual support in their explanations. We motivate this framework using the specific case-study of explaining the conclusions of field network engineering experts to non-technical planning staff and evaluate our results using feedback from two distinct user groups; domain-expert telecommunication engineers and non-expert desk agent staff. We also present and investigate two metrics designed to model the quality of explanations - Meet-In-The-Middle (MITM) and Trust-Your-Neighbours (TYN). Our analysis of these metrics offers new insights into the use of similarity knowledge for the evaluation of explanations.
Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons
Authors: Liang Dandan , Xue Zhigang , Xue Jinfeng , Xie Duanyang , Xiong Ke , Zhou Huixing , Zhang Fulei , Su Xuling , Wang Guanghua , Zou Qicheng , Liu Yi , Yang Jian , Ma Honghui , Peng Luying , Zeng Chunyu , Li Gang , Wang Li , Chen Yi-Han
Published: February 2021

Activation of the heart normally begins in the sinoatrial node (SAN). Electrical impulses spontaneously released by SAN pacemaker cells (SANPCs) trigger the contraction of the heart. However, the cellular nature of SANPCs remains controversial. Here, we report that SANPCs exhibit glutamatergic neuron-like properties. By comparing the single-cell transcriptome of SANPCs with that of cells from primary visual cortex in mouse, we found that SANPCs co-clustered with cortical neurons. Tissue and cellular imaging confirmed that SANPCs contained key elements of glutamatergic neurotransmitter system, expressing genes encoding glutamate synthesis pathway (Gls), ionotropic and metabotropic glutamate receptors (Grina, Gria3, Grm1 and Grm5), and glutamate transporters (Slc17a7). SANPCs highly expressed cell markers of glutamatergic neurons (Snap25 and Slc17a7), whereas Gad1, a marker of GABAergic neurons, was negative. Functional studies revealed that inhibition of glutamate receptors or transporters reduced spontaneous pacing frequency of isolated SAN tissues and spontaneous Ca2+ transients frequency in single SANPC. Collectively, our work suggests that SANPCs share dominant biological properties with glutamatergic neurons, and the glutamatergic neurotransmitter system may act as an intrinsic regulation module of heart rhythm, which provides a potential intervention target for pacemaker cell-associated arrhythmias.
Dynamic Distribution of High-Rate Data Processing from CERN to Remote HPC Data Centers
Authors: Boccali T. , Cameron D. , Cardo N. , Conciatore D. , Di Girolamo A. , Dissertori G. , Fernandez P. , Filipcic A. , Gila M. , Grab C. , Elmsheuser J. , Jankauskas V. , Klimentov A. , Kovalskyi D. , Lammel S. , Petrusic D. , Shulthess T. C. , Sciacca F. G. , Serfon C. , Walker R. , Wissing C.
Published: February 2021

The prompt reconstruction of the data recorded from the Large Hadron Collider (LHC) detectors has always been addressed by dedicated resources at the CERN Tier-0. Such workloads come in spikes due to the nature of the operation of the accelerator and in special high load occasions experiments have commissioned methods to distribute (spill-over) a fraction of the load to sites outside CERN. The present work demonstrates a new way of supporting the Tier-0 environment by provisioning resources elastically for such spilled-over workflows onto the Piz Daint Supercomputer at CSCS. This is implemented using containers, tuning the existing batch scheduler and reinforcing the scratch file system, while still using standard Grid middleware. ATLAS, CMS and CSCS have jointly run selected prompt data reconstruction on up to several thousand cores on Piz Daint into a shared environment, thereby probing the viability of the CSCS high performance computer site as on demand extension of the CERN Tier-0, which could play a role in addressing the future LHC computing challenges for the high luminosity LHC.
Battery Discharge from Monday to Friday: Background Social Stress at Work is Associated with more Rapid Accumulation of Fatigue
Authors: Elfering Achim , Kottwitz Maria U. , Semmer Norbert K.
Published: February 2021

Purpose

This field study investigated the effects of background social stress at work on the weekly course of evening fatigue.

Methods

Male employees of a Swiss organisation reported their fatigue after work and at 9 pm in the evening over three weeks. A total of 482 evening fatigue measurements from 34 male participants were subjected to multilevel analysis.

Results

Sleep quality in the previous night and fatigue after work predicted evening fatigue. Evening fatigue was not associated with the time spent on daily housework or child care. There was a linear increase in evening fatigue across weekdays and a main effect of workplace social stressors on evening fatigue. Sleep quality during the previous night mediated the link between background social stressors and evening fatigue. Moreover, an interaction between workplace social stressors and working days indicated that fatigue accumulated faster during the working week in those reporting a high level of social stress at work.

Conclusion

Social stress at work seems to accelerate the loss of resources over consecutive workdays. The analysis of workplace social stressors and other potential moderators of resource dynamics contributes to our understanding of work-related stress, including the role of background stressors and the temporal dynamics of resource loss.
Inference for time-varying lead–lag relationships from ultra-high-frequency data
Authors: Koike Yuta
Published: February 2021

A new approach for modeling lead–lag relationships in high-frequency financial markets is proposed. The model accommodates non-synchronous trading and market microstructure noise as well as intraday variations of lead–lag relationships, which are essential for empirical applications. A simple statistical methodology for analyzing the proposed model is presented, as well. The methodology is illustrated by an empirical study to detect lead–lag relationships between the S&P 500 index and its two derivative products.
Right Heart Thrombus and Pulmonary Embolism in Patients with Life-Threatening Bleeding: Management of a Complex Condition
Authors: Bentivegna Enrico , Luciani Michelangelo , Spuntarelli Valerio , Sesti Giorgio , Del Porto Flavia , Martelletti Paolo
Published: February 2021

Right heart thrombus (RHT) in transit is an uncommon condition associated with high mortality. Increased use of echocardiography has allowed an easier detection of RHT; however, there is no consensus about the most appropriate management of this critical situation. Therapeutic strategy should be decided according to patient’s haemodynamic parameters, clinical data, and bleeding risk. This paper, referring to the most current evidences, underlines the difficulty to establish the best therapeutic strategies in RHT among complex patients as there are no relevant guidelines. In some conditions, multidisciplinary management is the best way to find the most correct therapy despite the bad prognosis.
Numerical simulations and experiments on droplet coalescence dynamics over a liquid–air interface: mechanism and effect of droplet-size/surface-tension
Authors: Shaikh Javed , Patil Nagesh D. , Sharma Atul , Bhardwaj Rajneesh
Published: February 2021

Present study is on partial/complete coalescence dynamics of a droplet (surrounded by air) over a horizontal pool of the same liquid. Experimental and numerical studies are presented for both isopropanol and glycerol droplet of a constant diameter. Numerical study is presented in more detail for the isopropanol droplet to study the effect of diameter ($$D=0.035-6.7 mm$$

D
=
0.035
-
6.7
m
m

) and surface tension coefficient ($$\gamma =2-200 mN/m$$

γ
=
2
-
200
m
N
/
m

) on the coalescence dynamics. For partial coalescence of an isopropanol droplet and complete coalescence of a glycerol droplet, excellent agreement is demonstrated between our numerically and experimentally obtained interface dynamics; and a qualitative discussion on the mechanism of the partial and complete coalescence is presented. Three regimes of partial coalescence − viscous, inertio-capillary and gravity − proposed in the literature for a liquid-liquid system are presented here for the present liquid-air system while studying the effect of diameter of the isopropanol droplet. Probably for the first time in the literature, our numerical study presents a flow and vorticity dynamics based quantitativeevidence of the coalescence-mechanism, analogy with a freely vibrating Spring-Mass-Damper System, the gravity regime for a liquid-gas system, and the effect of surface tension coefficient $$\gamma$$
γ
based coalescence dynamics study. The associated novel $$\gamma$$
γ
based droplet coalescence regime map presents a critical Ohnesorge number $$Oh_{c}$$

O

h
c

and critical Bond number $$Bo_{c}$$

B

o
c

for a transition from partial to full coalescence; and such critical values are also presented for the transition under effect of the droplet diameter. The critical values based transition boundaries, obtained separately for the varying D and varying $$\gamma$$
γ
, are demonstrated to be in excellent agreement with a correlation reported in the literature.
Membrane nanotubes are ancient machinery for cell-to-cell communication and transport. Their interference with the immune system
Authors: Matkó János , Tóth Eszter Angéla
Published: February 2021

Nanotubular connections between mammalian cell types came into the focus only two decades ago, when “live cell super-resolution imaging” was introduced. Observations of these long-time overlooked structures led to understanding mechanisms of their growth/withdrawal and exploring some key genetic and signaling factors behind their formation. Unbelievable level of multiple supportive collaboration between tumor cells undergoing cytotoxic chemotherapy, cross-feeding” between independent bacterial strains or “cross-dressing” collaboration of immune cells promoting cellular immune response, all via nanotubes, have been explored recently. Key factors and "calling signals" determining the spatial directionality of their growth and their overall in vivo significance, however, still remained debated. Interestingly, prokaryotes, including even ancient archaebacteria, also seem to use such NT connections for intercellular communication. Herein, we will give a brief overview of current knowledge of membrane nanotubes and depict a simple model about their possible “historical role”.
Dual rolls equal channel extrusion as unconventional SPD process of the ultralow-carbon steel: finite element simulation, experimental investigations and microstructural analysis
Authors: Jabłońska M. B. , Kowalczyk K. , Tkocz M. , Bulzak T. , Bednarczyk I. , Rusz S.
Published: February 2021

The paper presents results of FEM modelling as well as properties and microstructure of the ultralow-carbon ferritic steel after the unconventional SPD process—DRECE (dual rolls equal channel extrusion). Based on the conducted numerical simulation information about the deformation behaviour of a steel strip during the DRECE process was obtained. The simulation results were experimentally verified. The influence of DRECE process on hardness distribution, fracture behaviour and microstructure evolution of the investigated steel was analysed. The increase of steel strength properties after subsequent deformation passes was confirmed. The microstructural investigations revealed that the processed strips exhibit the dislocation cell microstructure and subgrains with mostly low-angle grain boundaries. The grains after processing had relatively high dislocation density and intense microband formation was observed. It was also proved that this unconventional SPD method fosters high grain refinement.
Paving the way to achieving the United Nations Sustainable Development Goals for women from Indigenous communities: lessons from Attappady, India
Authors: Thomas Sarah T. , Thomas Elizabeth T. , McLean Michelle , Titus Thomas T.
Published: February 2021

India is home to the world’s second largest Indigenous population, comprising 8.6% of the national population. They are constitutionally recognised as ‘Scheduled Tribes’ to aid their development after centuries of oppression and socio-cultural marginalisation through the caste system. Limited disaggregated data exist on India’s Scheduled Tribe populations’ health outcomes, including for Indigenous women. Kerala, one of India’s southern states, is an intriguing case study. The State has outperformed other Indian states and South Asian countries with respect to a number of health and education indicators despite its more modest economic performance. Relatively little is known, however, about whether the State’s tribal or ‘Adivasi’ population is prospering. This article used data from a cross-sectional observational study of tribal women conducted in the Attappady area in the Palakkad district in Kerala, South India, which has a dense tribal population. The outcomes for these communities were compared with the relevant United Nations 2030 Sustainable Development Goal (SDG) indicators as well as Kerala State data to identify areas of growth and need. The findings of this case study highlight successes as well as persisting gaps in health outcomes for women and children in marginalised tribal communities. Using a strengths-based approach, we propose possible strategies to address the perceived gaps.
Economic Evaluation of Investments in Airports: Recent Developments
Authors: Forsyth Peter , Niemeier Hans-Martin , Njoya Eric Tchouamou
Published: February 2021

The problem of how to evaluate investments in airports has now been studied for over 50 years. This paper analyzes the use of different methods like cost–benefit analysis (CBA), economic impact analysis (EIA), and computable general equilibrium (CGE) models to address the question. It assesses the strength and weaknesses of each method, and it discusses which methods have been used in different countries. The paper argues that the CBA approach and the newer CGE modeling approach address the policy issue well and that both methods are appropriate, although improvements are possible, especially in the newer aspects of evaluation. Furthermore, more data intensive CGE models are able to analyze broader aspects of the evaluation question for which CBA has had difficulty. EIA does not address the problem satisfactorily, and it misleads air transport policy. But this evaluation contrasts sharply with practice. EIA has been extensively used to decide on airport investment. CGE approaches are very promising, though further work is needed for them to reach their full potential. This paper pays particular attention to the relationship between CBA and CGE in airport investment evaluation and also the possible role of wider economic benefits (WEBs) of aviation in evaluation.
Neural Antibody Testing for Autoimmune Encephalitis: A Canadian Single-Centre Experience
Authors: Budhram Adrian , Mirian Ario , McFadden Sean , Edmond Pamela , Bhayana Vipin , Yang Liju
Published: February 2021

Neural antibodies have emerged as useful biomarkers in suspected autoimmune encephalitis. We reviewed results of neural antibody testing (anti-N-methyl D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein (LGI1), contactin-associated protein-like 2 (CASPR2), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), γ-aminobutyric acid type B receptor (GABA(B)R), dipeptidyl-peptidase-like protein-6 (DPPX), IgLON family member 5 (IgLON5) and glutamic acid decarboxylase-65 (GAD65)) using cell-based assays (CBAs) and tissue indirect immunofluorescence (TIIF) at our centre. Our findings suggest increased clinical sensitivity of CBA compared to TIIF. However, this may come at some expense to clinical specificity, as evidenced by possible false-positive results when weak serum positivity by CBA was observed for certain antibodies (i.e. anti-NMDAR, CASPR2). In such cases, correlation with serum TIIF, as well as CSF CBA and TIIF, aids in identifying true-positive results.
“This Is Not A Rule”: COVID-19 in England & Wales and Criminal Justice Governance via Guidance
Authors: SORABJI John , VAUGHAN Steven
Published: February 2021

While soft law is an integral part of the efficient and effective functioning of public administration in England & Wales, the extent to which it was deployed in response to COVID-19 is striking, with over 400 pieces of “guidance and regulations” created. In this article, we consider the general place of soft law in administrative law in England & Wales and the broad regulatory framework, including soft law, that governs the COVID-19 pandemic. This allows us to take a deep dive into COVID-19 and the criminal justice system, showing how the senior judiciary relied predominately on soft law (judicial guidance and protocols) to manage the system (set against the backdrop of targeted legislation and a limited number of Practice Directions, which have the force of law). We argue that the senior judiciary’s approach to the use of COVID-19 soft law has, in many ways, been more effective than that taken by the government. Yet there remains room for improvement, particularly in the nature of the judicial guidance issued and about what guidance was in place and when.
Hydrogen peroxide vapor decontamination of N95 respirators for reuse
Authors: Kenney Patrick A. , Chan Benjamin K. , Kortright Kaitlyn E. , Cintron Margaret , Russi Mark , Epright Jacqueline , Lee Lorraine , Balcezak Thomas J. , Havill Nancy L. , Martinello Richard A.
Published: February 2021

Objective:

The coronavirus disease 2019 (COVID-19) pandemic has led to global shortages of N95 respirators. Reprocessing of used N95 respirators may provide a higher filtration crisis alternative, but whether effective sterilization can be achieved for a virus without impairing respirator function remains unknown. We evaluated the viricidal efficacy of Bioquell vaporized hydrogen peroxide (VHP) on contaminated N95 respirators and tested the particulate particle penetration and inhalation and exhalation resistance of respirators after multiple cycles of VHP.

Methods:

For this study, 3M 1870 N95 respirators were contaminated with 3 aerosolized bacteriophages: T1, T7, and Pseudomonas phage phi-6 followed by 1 cycle of VHP decontamination using a BQ-50 system. Additionally, new and unused respirators were sent to an independent laboratory for particulate filter penetration testing and inhalation and exhalation resistance after 3 and 5 cycles of VHP.

Results:

A single VHP cycle resulted in complete eradication of bacteriophage from respirators (limit of detection 10 PFU). Respirators showed acceptable limits for inhalation/exhalation resistance after 3 and 5 cycles of VHP. Respirators demonstrated a filtration efficiency >99 % after 3 cycles, but filtration efficiency fell below 95% after 5 cycles of HPV.

Conclusion:

Bioquell VHP demonstrated high viricidal activity for N95 respirators inoculated with aerosolized bacteriophages. Bioquell technology can be scaled for simultaneous decontamination of a large number of used but otherwise intact respirators. Reprocessing should be limited to 3 cycles due to concerns both about impact of clinical wear and tear on fit, and to decrement in filtration after 3 cycles.
Towards a definitive symptom structure of obsessive−compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals
Authors: Cervin Matti , Miguel Euripedes C. , Güler Ayşegül Selcen , Ferrão Ygor A. , Erdoğdu Ayşe Burcu , Lazaro Luisa , Gökçe Sebla , Geller Daniel A. , Yulaf Yasemin , Başgül Şaziye Senem , Özcan Özlem , Karabekiroğlu Koray , Fontenelle Leonardo F. , Yazgan Yankı , Storch Eric A. , Leckman James F. , do Rosário Maria Conceição , Mataix-Cols David
Published: February 2021

Background

The symptoms of obsessive−compulsive disorder (OCD) are highly heterogeneous and it is unclear what is the optimal way to conceptualize this heterogeneity. This study aimed to establish a comprehensive symptom structure model of OCD across the lifespan using factor and network analytic techniques.

Methods

A large multinational cohort of well-characterized children, adolescents, and adults diagnosed with OCD (N = 1366) participated in the study. All completed the Dimensional Yale-Brown Obsessive−Compulsive Scale, which contains an expanded checklist of 87 distinct OCD symptoms. Exploratory and confirmatory factor analysis were used to outline empirically supported symptom dimensions, and interconnections among the resulting dimensions were established using network analysis. Associations between dimensions and sociodemographic and clinical variables were explored using structural equation modeling (SEM).

Results

Thirteen first-order symptom dimensions emerged that could be parsimoniously reduced to eight broad dimensions, which were valid across the lifespan: Disturbing Thoughts, Incompleteness, Contamination, Hoarding, Transformation, Body Focus, Superstition, and Loss/Separation. A general OCD factor could be included in the final factor model without a significant decline in model fit according to most fit indices. Network analysis showed that Incompleteness and Disturbing Thoughts were most central (i.e. had most unique interconnections with other dimensions). SEM showed that the eight broad dimensions were differentially related to sociodemographic and clinical variables.

Conclusions

Future research will need to establish if this expanded hierarchical and multidimensional model can help improve our understanding of the etiology, neurobiology and treatment of OCD.
Dynamic Analysis of the UVMS: Effect of Disturbances, Coupling, and Joint-Flexibility on End-Effector Positioning
Authors: Shah Umer Hameed , Karkoub Mansour , Kerimoglu Deniz , Wang Hong-Du
Published: February 2021

This paper investigates the dynamics of an underwater vehicle-manipulator system (UVMS) consisting of a two-link flexible-joint manipulator affixed to an autonomous underwater vehicle. The quasi-Lagrange formulation is utilized in deriving a realistic mathematical model of the UVMS considering joints’ friction, hysteretic coupling between the joints and links, and the nonlinear hydrodynamic forces acting on the system, such as added mass, viscous damping, buoyancy, drag, and vortex-induced forces. Numerical simulations are performed to demonstrate the effects of hydrodynamic forces and system coupling between the vehicle and the manipulator and the joints and the links on the precise positioning of the end effector.
Economic impact of the use of the National Surgical Quality Improvement Program
Authors: Fansi Alvine , Ly Angela , Mayrand Julie , Wassef Maggy , Rho Aldanie , Beauchamp Sylvie
Published: February 2021

Objectives

The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP®) is a validated, risk-adjusted database for improving the quality and security of surgical care. ACS NSQIP can help participating hospitals target areas that need improvement. The aim of this study was to systematically review the literature analyzing the economic impact of using NSQIP. This paper also provides an estimation of annual cost savings following the implementation of NSQIP and quality improvement (QI) activities in two hospitals in Quebec.

Methods

In June 2018, we searched in seven databases, including PubMed, Embase, and NHSEED for economic evaluations based on NSQIP data. Contextual NSQIP databases from two hospitals were collected and analyzed. A cost analysis was conducted from the hospital care perspective, comparing complication costs before and after 1 year of the implementation of NSQIP and QI activities. The number and the cost of complications are measured. Costs are presented in 2018 Canadian dollars.

Results

Out of 1,612 studies, 11 were selected. The level of overall evidence was judged to be of moderate to high quality. In general, data showed that, following the implementation of NSQIP and QI activities, a significant decrease in complications and associated costs was observed, which improved with time. In the cost analysis of contextual data, the reduction in complication costs outweighed the cost of implementing NSQIP. However, this cost analysis did not take into account the costs of QI activities.

Conclusions

NSQIP improves complication rates and associated costs when QI activities are implemented.
Atomized urbanism: secrecy and security from the Gulag to the Soviet closed cities
Authors: Siddiqi Asif
Published: February 2021

This article recovers the early history of the Soviet ‘closed city’, towns that during the Cold War were absent from maps and unknown to the general public due to their involvement in weapons research. I argue that the closed cities echoed and appropriated features of the Stalinist Gulag camp system, principally their adoption of physical isolation and the language of obfuscation. In doing so, I highlight a process called ‘atomized urbanism’ that embodies the tension between the obdurate reality of the city and the goal of the state to obliterate that reality through secrecy. In spatial terms, ‘atomized’ also describes the urban geography of these cities which lacked any kind of organic suburban expansion.
Hyperlactataemia as a predictor of adverse outcomes post-cardiac surgery in neonates with congenital heart disease
Authors: Valencia Eleonore , Staffa Steven J. , Nathan Meena , Smith-Parrish Melissa , Kaza Aditya K. , DiNardo James A. , Nasr Viviane G.
Published: February 2021

Objective:

To evaluate the discriminative ability of hyperlactataemia for early morbidity and mortality in neonates with CHD following cardiac surgery.

Methods:

Retrospective, observational study of neonates who underwent cardiac surgery on cardiopulmonary bypass at a tertiary care children’s hospital from June 2015 to June 2019. The primary predictor was lactate. The primary composite outcome was defined as ≥1 of the following: cardiac arrest or extracorporeal membrane oxygenation within 72 hours or 30-day mortality post-operatively. The secondary outcome was the presence of major residual lesions, according to the Technical Performance Score.

Results:

Of 432 neonates, 28 (6.5%) sustained the composite outcome. On univariate analysis, peak lactate within 48 hours, increase in lactate from ICU admission through 12 hours, and single ventricle physiology were significantly associated with the composite outcome. The peak lactate occurred at a median of 2.9 hours (interquartile range: 1, 35) before the event. Through multi-variable analysis, a multi-variable risk algorithm was created. Predicted probabilities demonstrated an increasing risk based on single ventricle status and delta lactate, ranging from 1.8% (95% CI: 0.9, 3.9) to 52.4% (95% CI: 32.4, 71.7). The model had good discriminative ability for the composite outcome on receiver operating characteristic analysis (area under the curve = 0.79; 95% CI: 0.75, 0.89). Moreover, a peak lactate of 7.3 mmol/l or greater was significantly associated with the presence of a major residual lesion (odds ratios: 5.16, 95% CI: 3.01, 8.87).

Conclusions:

We present a simple, two-variable model, including delta lactate in the immediate post-operative period and single ventricle status, to prognosticate the risk of early morbidity and mortality in neonates undergoing cardiac surgery for potential intervention.
Impact of CT-based planning and bladder volume changes on the dosimetry of vaginal vault brachytherapy
Authors: Venkatasai Jeyaanth , Ramireddy Jebakarunya , Sathyamurthy Arvind , Godson Henry Finlay , Karuppusami Reka , Das Saikat , Ram Thomas Samuel
Published: February 2021

Aim:

To compare dose to target and organs at risk (OARs) in conventional plan (2D) versus computed tomography (CT)-based three-dimensional (3D) plan in vaginal cuff brachytherapy (VBT) and to compare the effect of bladder distension on target and OARs dosimetry.

Materials and methods:

Post-hysterectomy patients with an indication for VBT were included in the study. All patients underwent planning CT scans with a full bladder and an empty bladder protocol. For each CT, two plans were generated—one library-based 2D plan and another CT-based 3D plan. Dosimetric parameters were recorded for clinical target volume (CTV) and OARs.

Results:

A total of 92 observations were made from data collected from 46 patients. Difference between CTV dose in terms of 2D and 3D plans were not statistically significant for CTV (p = 0·11). Significant reduction in D0·1cc, D1cc and D2cc dose parameters were observed in bladder, rectum, sigmoid and bowel doses with the 3D plan (p < 0·001). Bladder distension showed a 20% reduction in dose for bowel (p < 0·001). Bladder distension also showed a 6·12% (p = 0·047) increase in D2cc, but there was a significant reduction in the mean dose to the bladder.

Conclusion:

Our study demonstrates the dosimetric benefits with 3D CT-based planning for VBT over 2D-based conventional planning and benefit of bladder distension in the reduction of bowel dose without compromising dose to the target volume.
RAISING THE LEVEL OF AUTOMORPHIC REPRESENTATIONS OF OF UNITARY TYPE
Authors: Anastassiades Christos , Thorne Jack A.
Published: February 2021

We use the endoscopic classification of automorphic representations of even-dimensional unitary groups to construct level-raising congruences.
Stroke rate after thoracic endovascular aortic repair using de-airing of stentgrafts with high-volume of saline solution
Authors: Branzan Daniela , Geisler Antonia , Steiner Sabine , Lautenschlaeger Tina , Doss Markus , Matschuck Manuela , Scheinert Dierk , Schmidt Andrej
Published: February 2021

Summary: Background: Our aim was to determine the rate of ischemic stroke following thoracic endovascular aortic repair (TEVAR) after reducing gas volume released during stentgraft deployment by de-airing of thoracic stentgrafts with high-volume of 0.9% heparinized saline solution. Patients and methods: A single center retrospective analysis of all consecutive patients undergoing TEVAR from 2014 to 2019 was performed. All thoracic stentgrafts were flushed with 120 ml 0.9% heparinized saline solution before implantation, according to our institutional protocol. Endpoints were in-hospital rates of ischemic stroke and spinal cord ischemia (SCI), and all-cause mortality. Results: One hundred and fifty-four patients (mean age: 66.8 ± 13.6 years, 64.9% males) were treated with TEVAR during the study period. Indications for treatment were thoracic aortic aneurysms (n = 75, 48.7%), acute type B aortic dissections (n = 46, 29.9%), aortic arch aneurysms and penetrating aortic ulcers (n = 28, 18.2%), and blunt traumatic aortic injuries (n = 5, 3.2%). Timing of procedure was urgent in 75 patients (48.7%). Proximal landing zone were zone 0–1–2 (n = 75, 48.7%), zone 3 (n = 66, 42.9%) and zone 4 (n = 13, 8.4%). Supra-aortic vessels were revascularized with custom-made fenestrated stentgrafts in 9 patients (5.8%), using chimney technique in 4 patients (2.6%), and with debranching procedures in 19 patients (12.3%). Left subclavian artery was covered without revascularization in 46 patients (29.9%). In-hospital stroke occurred in two patients (1.3%) and SCI in another two patients (1.3%). In-hospital mortality rate was 0.6%. No further in-hospital events were noted. Conclusions: De-airing of stentgrafts with high-volume of 0.9% heparinized saline solution seems to be safe and can be used as an adjunct to keep occurrence of neurological events after TEVAR as low as possible.
The Deep Structure of the Alps Based on the CIFALPS Seismic Experiment: A Synthesis
Authors: Malusà M. G. , Guillot S. , Zhao L. , Paul A. , Solarino S. , Dumont T. , Schwartz S. , Aubert C. , Baccheschi P. , Eva E. , Lu Y. , Lyu C. , Pondrelli S. , Salimbeni S. , Sun W. , Yuan H.
Published: February 2021

The European Alps are the site where classic geologic concepts such as nappe theory, continental subduction and slab breakoff have been first proposed. However, the deep tectonic structure of the Alps has long been poorly constrained by independent geophysical evidence. This review paper summarizes the main results of the CIFALPS passive seismic experiment, that was launched by Chinese, French and Italian scientists in the 2010s to provide new insights on the deep tectonic structure of the Alpine region. The application of a wide range of tomographic methods to the analysis of a single fossil subduction zone makes the CIFALPS experiment a potential reference case for the analysis of other orogenic belts. Major results include: (i) the first seismic evidence of European continental crust subducted into the Adriatic upper mantle, beneath the place where coesite was first recognized in continental (U)HP rocks in the Alps; (ii) evidence of a major involvement of the mantle wedge during (U)HP rock exhumation; (iii) evidence of a serpentinized plate interface favoring continental subduction; (iv) evidence of a continuous slab beneath the Western and Central Alps, ruling out the classic model of slab breakoff magmatism; (v) evidence of a polyphase development of anisotropic fabrics in the Alpine mantle, either representing active mantle flows or fossil fabrics inherited from previous rifting stages. Detection of these major tectonic features allows to propose interpretive geologic cross‐sections at the scale of the lithosphere and upper mantle, providing a baseline for future analyses of active continental margins.