bluuebunny/crossref_metadata_2025 huggingface dataset:
Epigallocatechin-3-gallate inhibits H2O2-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor
Authors: Yan Xue , Li Yanfei , Yu Han , Wang Wei , Wu Chunyan , Yang Yang , Hu Yongjia , Shi Xiujuan , Li Jue
Published: August 2017

Epigallocatechin-3-gallate (EGCG) is one of the major polyphenolic compounds present in green tea extracts and has been used as a potential drug for the treatment of numerous diseases. The present study aimed to elucidate the role and mechanism of EGCG in protecting against H2O2-induced apoptosis in mouse vascular smooth muscle cells (VSMCs). VSMCs were pretreated with various concentrations of EGCG for 2 hours prior to treatment with H2O2. Treatment with H2O2 significantly decreased the cell viability and induced apoptosis of VSMCs, which were attenuated by pretreatment with EGCG. In particular, EGCG pretreatment significantly inhibited the H2O2-induced upregulation of cleaved forms of caspase-3, caspase-8, and caspase-9, Bax, CathepsinD, and downregulation of Bcl-2. Moreover, the antioxidation effect of EGCG on VSMCs was determined to be associated with the 67kD laminin receptor (67LR). Our results demonstrated that EGCG improved cell viability and protected VSMCs against oxidative stress through both extrinsic and intrinsic pathways, while 67LR is likely to be an active and key receptor of EGCG. These findings provide a novel molecular mechanism of EGCG in inhibiting H2O2-induced apoptosis in VSMCs, as well as its function in preventing the development of atherosclerosis.
Directional cell expansion requires NIMA-related kinase 6 (NEK6)-mediated cortical microtubule destabilization
Authors: Takatani Shogo , Ozawa Shinichiro , Yagi Noriyoshi , Hotta Takashi , Hashimoto Takashi , Takahashi Yuichiro , Takahashi Taku , Motose Hiroyasu
Published: August 2017

Plant cortical microtubules align perpendicular to the growth axis to determine the direction of cell growth. However, it remains unclear how plant cells form well-organized cortical microtubule arrays in the absence of a centrosome. In this study, we investigated the functions of Arabidopsis NIMA-related kinase 6 (NEK6), which regulates microtubule organization during anisotropic cell expansion. Quantitative analysis of hypocotyl cell growth in the nek6-1 mutant demonstrated that NEK6 suppresses ectopic outgrowth and promotes cell elongation in different regions of the hypocotyl. Loss of NEK6 function led to excessive microtubule waving and distortion, implying that NEK6 suppresses the aberrant cortical microtubules. Live cell imaging showed that NEK6 localizes to the microtubule lattice and to the shrinking plus and minus ends of microtubules. In agreement with this observation, the induced overexpression of NEK6 reduced and disorganized cortical microtubules and suppressed cell elongation. Furthermore, we identified five phosphorylation sites in β-tubulin that serve as substrates for NEK6 in vitro. Alanine substitution of the phosphorylation site Thr166 promoted incorporation of mutant β-tubulin into microtubules. Taken together, these results suggest that NEK6 promotes directional cell growth through phosphorylation of β-tubulin and the resulting destabilization of cortical microtubules.
Comparisons of magnetic charge and axial charge meson cloud distributions in the PCQM
Authors: Liu X. Y. , Liu Z. J. , Khosonthongkee K. , Limphirat A. , Yan Y.
Published: August 2017

The meson cloud distributions in r-space are extracted from the nucleon electromagnetic and axial form factors which are derived in the perturbative chiral quark model. The theoretical results indicate that the magnetic charge and axial charge distributions of the three-quark core have the similar distributions in r-space, the magnetic charge distributions of the meson cloud and three-quark core are more or less in the same region and peak at distances of around 0.4 fm, which is in good agreement with the finding of works in the framework of chiral perturbation theory, but the axial charge meson cloud distributes mainly inside the three-quark core.
Novel fluorescent cationic benzothiazole dye that responds to G-quadruplex aptamer as a novel K+ sensor
Authors: Sun Xin , Li Qian , Xiang Junfeng , Wang Lixia , Zhang Xiufeng , Lan Ling , Xu Shujuan , Yang Fengmin , Tang Yalin
Published: August 2017

A fluorescent cationic benzothiazole dye that selectively targets a G-quadruplex aptamer was designed and synthesized as a K+ sensor.
Single-step homogeneous immunoassay for detecting prostate-specific antigen using dual-color light scattering of metal nanoparticles
Authors: Vial Stéphanie , Wenger Jérôme
Published: August 2017

Conventional sandwich-type immunoassays are widely used for protein biomarker detection, yet their workflows are challenged by the need for multiple incubation steps separated by washing cycles.
Lone pair-π interaction-induced generation of photochromic coordination networks with photoswitchable conductance
Authors: Liao Jian-Zhen , Chang Jian-Fei , Meng Lingyi , Zhang Hai-Long , Wang Sa-Sa , Lu Can-Zhong
Published: August 2017

Lone pair-π interaction-induced variation of the degree of charge-transfer was successfully used for switching the conductance of a photochromic coordination network.
By-product processing of Si3N4saw-tooth nanoribbons during carbon foam processing using pyrolysis–nitridation reactions
Authors: Farhan Shameel , Wang Rumin , Zhang Dandan , Li Kezhi
Published: August 2017

A novel concept of by-product processing of high-yield Si3N4nanoribbons over the outer surface of carbon foams containingin situgrown silicon nanowires during high temperature carbonization treatment.
The effect of Fe on the structure and electrical conductivity of sodium borosilicate glasses
Authors: Ciżman A. , Rysiakiewicz-Pasek E. , Krupiński M. , Konon M. , Antropova T. , Marszałek M.
Published: August 2017

We report the synthesis and characterization of iron-bearing sodium borosilicate glasses with an Fe2O3content lower than 10 mol%.
The reaction of Criegee intermediate CH2OO with water dimer: primary products and atmospheric impact
Authors: Sheps Leonid , Rotavera Brandon , Eskola Arkke J. , Osborn David L. , Taatjes Craig A. , Au Kendrew , Shallcross Dudley E. , Khan M. Anwar H. , Percival Carl J.
Published: August 2017

We investigate the kinetics and product distributions in the reaction CH2OO + water dimer – the main atmospheric removal route of Criegee intermediates.
Unravelling hydrogen bonding interactions of tryptamine–water dimer from neutral to cation
Authors: Liu Zongyuan , Trindle Carl O. , Gu Quanli , Wu Wei , Su Peifeng
Published: August 2017

The physical origin for the three intermolecular hydrogen bonds in the neutral and cationic forms of the tryptamine–water dimer is explored.
A ground state potential energy surface for HONO based on a neural network with exponential fitting functions
Authors: Pradhan Ekadashi , Brown Alex
Published: August 2017

Using CCSD(T)-F12/cc-pVTZ-F12 and CCSD(T)/CBS ab initio energies, two different six-dimensional ground state potential energy surfaces for HONO have been fit in sum-of-products form using neural network exponential fitting functions and tested by computing vibrational energies with MCTDH.
Guidelines and diagnostics for charge carrier tuning in thiophene-based wires
Authors: Gryn'ova Ganna , Ollitrault Pauline J. , Corminboeuf Clémence
Published: August 2017

Reported experimental trends in charge carrier tuning in single molecule junctions of oligothiophene-based wires are rationalized by means of frontier molecular orbital theory.
Surface-bound quadruple H-bonded dimers: formation and exchange kinetics
Authors: Gahtory Digvijay , Sen Rickdeb , Smulders Maarten M. J. , Zuilhof Han
Published: August 2017

While the mechanistic details of the dimerization of the self-complementary 2-ureido-4(1H)-pyrimidinone (UPy) motif are well studied in solution, no such investigation is available on a surface. Here we report an extensive study of hydrogen binding kinetics for quadruply H-bonded UPy arrays on aluminum surfaces and explore the ON/OFF capability of such arrays under externally controllable conditions. Also, we investigate the dynamic nature of this system whereby the interfacially H-bonded UPy is displaced by another UPy derivative in solution, and reveal the kinetics of the exchange process.
Quantitative exponential stability and stabilisation of discrete‐time Markov jump systems with multiplicative noises
Authors: Yan Zhiguo , Zhang Weihai , Park Ju H. , Liu Xiaoping
Published: August 2017

This study is concerned about the quantitative exponential stability (QES) and stabilisation of discrete‐time Markov jump systems with multiplicative noises. First, the defects of exponential stability in practical applications are analysed. Based on this analysis, a concept of the QES is given, and two stability criteria are derived. By utilising an auxiliary definition of general finite‐time stability (GFTS), the relations among QES, GFTS and finite‐time stability are established. Moreover, the quantitative exponential stabilisation is studied, and state feedback controller and the observer‐based controller are designed. Subsequently, the relation between the states' upper bound and states' decay rate of considered systems is quantitatively shown by a searching method. Finally, an example is used to illustrate the effectiveness of the authors' obtained results.
Low Gestational Age Is the Strongest Predictor for Severe Retinopathy of Prematurity and Adverse Outcomes at Two-Year Follow-Up in a Low Incidence Setting
Authors: Nobile Stefano , Bordignon Linda , Peretti Anna , Carnielli Virgilio
Published: August 2017

We aimed to determine the risk factors for type 1 ROP and outcomes at 2 years of corrected age among preterms born < 30 weeks of gestational age (GA) in a low-incidence setting. A cohort study with 447 infants was conducted. Those who underwent laser therapy for type 1 ROP were compared with controls by univariate and multivariate analysis. Neurological development was assessed by Bayley scales. Using univariate analysis, gestational age, sepsis, necrotizing enterocolitis, and insulin administration were found to be associated with type 1 ROP. Only GA remained significant with logistic regression. Infants with type 1 ROP had worse visual and neurodevelopmental outcomes at 2 years. Predictors of impaired neurodevelopment were type 1 ROP, surfactant administration, and bronchopulmonary dysplasia. Low GA was found to be a strong predictor of type 1 ROP, which was associated (along with surfactant administration and bronchopulmonary dysplasia) with worse neurological development.
Therapie der Essstörung durch Emotionsregulation
Authors: Sipos Valerija , Schweiger Ulrich , Jauch-Chara Kamila , Faßbinder Eva
Published: August 2017

Patientinnen mit Essstörung haben Schwierigkeiten in der Wahrnehmung von Emotionen. Sie haben Fertigkeitendefizite in der Akzeptanz, Modifikation und beim Handeln entgegengesetzt zu emotionsgetriebenem Verhalten. Sie nutzen gestörtes Essverhalten (Nahrungsrestriktion, Essanfälle und Erbrechen), aber auch Situationsvermeidung, Dissoziation und Substanzen als Instrumente der Emotionsvermeidung. Hieraus ergibt sich ein innovativer Ansatzpunkt der Behandlung.
Existence, regularity, and concentration phenomenon of nontrivial solitary waves for a class of generalized variable coefficient Kadomtsev-Petviashvili equation
Authors: Alves Claudianor O. , Miyagaki Olímpio H.
Published: August 2017

In this paper, we establish some results concerning the existence, regularity, and concentration phenomenon of nontrivial solitary waves for a class of generalized variable coefficient Kadomtsev-Petviashvili equation. Variational methods are used to get an existence result, as well as, to study the concentration phenomenon, while the regularity is more delicate because we are leading with functions in an anisotropic Sobolev space.
Spectral evolution of soft x-ray emission from optically thin, high electron temperature platinum plasmas
Authors: Hara Hiroyuki , Ohashi Hayato , Li Bowen , Dunne Padraig , O’Sullivan Gerry , Sasaki Akira , Suzuki Chihiro , Tamura Naoki , Sakaue Hiroyuki A. , Kato Daiji , Murakami Izumi , Higashiguchi Takeshi ,   LHD Experiment Group
Published: August 2017

The soft x-ray spectra of heavy element plasmas are frequently dominated by unresolved transition array (UTA) emission. We describe the spectral evolution of an intense UTA under optically thin conditions in platinum plasmas. The UTA was observed to have a peak wavelength around 4.6 nm at line-of-sight averaged electron temperatures less than 1.4 keV at electron densities of (2.5–7.5) × 1013 cm−3. The UTA spectral structure was due to emission from 4d–4f transitions in highly charged ions with average charge states of q = 20–40. A numerical simulation successfully reproduced the observed spectral behavior.
First-principles study of charged steps on 180° domain walls in ferroelectric PbTiO3
Authors: Jiang Y. X. , Wang Y. J. , Chen D. , Zhu Y. L. , Ma X. L.
Published: August 2017

The atomic-scale mechanism of domain wall motion in ferroelectrics is commonly accepted to be nucleation and the movement of steps on the domain walls. Although very important in understanding the mechanism of domain wall motion and domain switching, the detailed atomic structures of steps have nevertheless been scarcely explored. In this work, the charged steps of these structures on 180° domain walls in PbTiO3 were investigated using first-principles computations. Contrary to the previous understanding that there is a sudden jump at a step from one atomic plane to an adjacent plane, our computation results suggest that it is actually a gradual transition and the actual steps lie at atomic planes with the approximate Miller indices (3 0 1¯). A large polarization rotation was found around the steps, making the polarization distribution Ising–Néel-like. The barriers for the motion of steps along domain walls were found to be much lower than those for which the domain wall is moving as a whole. These findings provide valuable information for further investigations of the domain switching mechanism at the atomic scale.
Effect of nano-selenium and nano-zinc particles during in vitro maturation on the developmental competence of bovine oocytes
Authors: Abdel-Halim B. R. , Helmy Nermeen A.
Published: August 2017

The objectives of the current study were to evaluate the effects of supplemental nano-selenium (NSe) and nano-zinc oxide (NZn-O) particles during in vitro maturation (IVM) on DNA damage of cumulus cells, glutathione (GSH) concentration in bovine oocytes, subsequent embryo development and re-expansion rate of vitrified warmed blastocysts. The current study was conducted on bovine ovaries obtained from a local abattoir and transported to the laboratory in sterile phosphate buffer saline with antibiotics at 37°C, within 1 h after slaughter. Ovaries were pooled, regardless of stage of the oestrous cycle of the donor. Only cumulus-intact complexes with evenly granulated cytoplasm were selected for IVM. Experimental design included the following: Experiment 1 studied the effect of addition of 1.0 µg/mL NSe or NZn-O to IVM medium on DNA damage of cumulus cells; Experiment 2 evaluated the effects of NSe or NZn-O on intracellular glutathione in oocytes and cumulus cells; in Experiment 3, the development of oocytes matured in IVM medium supplemented with 1.0 µg/mL NSe or NZn-O was investigated; and in Experiment 4, the effects of adding 1.0 µg/mL NSe and NZn-O to in vitro fertilisation media on vitrified oocytes and embryos were investigated. The DNA damage in cumulus cells decreased with supplemental NSe and NZn-O at concentration of 1 µg/mL in the IVM medium (180.2 ± 21.4, 55.8 ± 4.3 and 56.6 ± 3.9 for the control and NSe and NZn-O groups respectively). Total GSH concentrations increased following supplementation with 1 µg/mL NSe and 1 µg/mL NZn-O, compared with the control group. Re-expansion rate of vitrified warmed blastocysts in experimental media containing NSe and NZn-O with ethylene glycol was higher than that of the control. In conclusion, providing NSe and NZn-O during oocyte maturation significantly increased both intracellular GSH concentration and DNA integrity of cumulus cells. Optimal embryo development was partially dependent on the presence of NSe and NZn-O during IVM. NSe and NZn-O during oocyte maturation act as a good cryoprotective agents of vitrified, warmed blastocysts.
Quantum repeaters based on trapped ions with decoherence-free subspace encoding
Authors: Zwerger M , Lanyon B P , Northup T E , Muschik C A , Dür W , Sangouard N
Published: August 2017

Quantum repeaters provide an efficient solution to distribute Bell pairs over arbitrarily long distances. While scalable architectures are demanding regarding the number of qubits that need to be controlled, here we present a quantum repeater scheme aiming to extend the range of present day quantum communications that could be implemented in the near future with trapped ions in cavities. We focus on an architecture where ion-photon entangled states are created locally and subsequently processed with linear optics to create elementary links of ion-ion entangled states. These links are then used to distribute entangled pairs over long distances using successive entanglement swapping operations performed using deterministic ion-ion gates. We show how this architecture can be implemented while encoding the qubits in a decoherence-free subspace to protect them against collective dephasing. This results in a protocol that can be used to violate a Bell inequality over distances of about 800 km assuming state-of-the-art parameters. We discuss how this could be improved to several thousand kilometres in future setups.
Large-Scale Atmospheric Dispersal Simulations Identify Likely Airborne Incursion Routes of Wheat Stem Rust Into Ethiopia
Authors: Meyer M. , Burgin L. , Hort M. C. , Hodson D. P. , Gilligan C. A.
Published: August 2017

In recent years, severe wheat stem rust epidemics hit Ethiopia, sub-Saharan Africa’s largest wheat-producing country. These were caused by race TKTTF (Digalu race) of the pathogen Puccinia graminis f. sp. tritici, which, in Ethiopia, was first detected at the beginning of August 2012. We use the incursion of this new pathogen race as a case study to determine likely airborne origins of fungal spores on regional and continental scales by means of a Lagrangian particle dispersion model (LPDM). Two different techniques, LPDM simulations forward and backward in time, are compared. The effects of release altitudes in time-backward simulations and P. graminis f. sp. tritici urediniospore viability functions in time-forward simulations are analyzed. Results suggest Yemen as the most likely origin but, also, point to other possible sources in the Middle East and the East African Rift Valley. This is plausible in light of available field surveys and phylogenetic data on TKTTF isolates from Ethiopia and other countries. Independent of the case involving TKTTF, we assess long-term dispersal trends (>10 years) to obtain quantitative estimates of the risk of exotic P. graminis f. sp. tritici spore transport (of any race) into Ethiopia for different ‘what-if’ scenarios of disease outbreaks in potential source countries in different months of the wheat season.
Using Economic Evaluation to Illustrate Value of Care for Improving Patient Safety and Quality: Choosing the Right Method
Authors: Padula William V. , Lee Ken K.H. , Pronovost Peter J.
Published: August 2017

To scale and sustain successful quality improvement (QI) interventions, it is recommended for health system leaders to calculate the economic and financial sustainability of the intervention. Many methods of economic evaluation exist, and the type of method depends on the audience: providers, researchers, and hospital executives. This is a primer to introduce cost-effectiveness analysis, budget impact analysis, and return on investment calculation as 3 distinct methods for each stakeholder needing a measurement of the value of QI at the health system level. Using cases for the QI of hospital-acquired condition rates (e.g., pressure injuries), this primer proceeds stepwise through each method beginning from the same starting point of constructing a model so that the repetition of steps is minimized and thereby capturing the attention of all intended audiences.
Optogenetic silencing of primary afferents reduces evoked and ongoing bladder pain
Authors: Samineni Vijay K. , Mickle Aaron D. , Yoon Jangyeol , Grajales-Reyes Jose G. , Pullen Melanie , Crawford Kaitlyn , Noh Kyung Nim , Gereau Graydon B. , Vogt Sherri , Lai H. Henry , Rogers John A. , Gereau Robert W.
Published: August 2017

Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition of bladder sensory afferents temporarily relieves pain. Here, we explored the possibility that optogenetic inhibition of bladder sensory afferents could be used to modulate bladder pain. Specifically, we chose to study the role of Nav1.8+sensory afferents before and after induction of a mouse model of bladder pain. The light-activated inhibitory proton pump Archaerhodopsin (Arch) was expressed under control of the Nav1.8+promoter to selectively silence these neurons. Optically silencing Nav1.8+afferents significantly blunted the evoked visceromotor response to bladder distension and led to small but significant changes in bladder function. To study of the role of these fibers in freely behaving mice, we developed a fully implantable, flexible, wirelessly powered optoelectronic system for the long-term manipulation of bladder afferent expressed opsins. We found that optogenetic inhibition of Nav1.8+fibers reduced both ongoing pain and evoked cutaneous hypersensitivity in the context of cystitis, but had no effect in uninjured, naïve mice. These results suggest that selective optogenetic silencing of bladder afferents may represent a potential future therapeutic strategy for the treatment of bladder pain.
Effect of 40Gy irradiation on the ultrastructure, biochemistry, morphology and cytology during spermatogenesis in the southern green stink bugNezara viridula(Hemiptera: Pentatomidae)
Authors: Stringer L. D. , Harland D. P. , Grant J.E. , Laban J. , Suckling D. M.
Published: August 2017

A study on theNezara viridulamale gonad cells was undertaken to compare normal development and development of insect cells after irradiation of 4thinstar nymphs with a dose of 40 Gray. Visually, morphologically, biochemically and cytologically the insects were not all uniformly affected by the radiation. In all aspects of development there was a range from severely affected to nearly normal. Irradiated insects appeared to move slowly and were unable to mate with non-irradiated females. The testes of the males varied from bright orange to grey in colour and all were smaller in size than non-irradiated testes. The ultrastructure of the developing sperm showed abnormalities the axonemes, the mitochrondrial derivatives, nebenkern and centrioles. Cytochemically, the main difference observed was the presence of granules heavily stained with acid phosphatase in between mitochrondrial derivatives. The chromosomes of these irradiated insects were highly fragmented. Although a few sperm in irradiated insects appeared normal no progeny were produced as insect did not mate. The sterile insect technique (SIT) requires a balance between the effective radiation dose to achieve partial or full sterility, while maintaining physical fitness. The observation that abnormalities varied from almost none to severe at 40Gy could help the development of SIT for control ofN.viridulaand other Pentatomidae.
Anti-infective potential of a quorum modulatory polyherbal extract (Panchvalkal) against certain pathogenic bacteria
Authors: Patel Pooja , Joshi Chinmayi , Palep Hanmanthrao , Kothari Vijay
Published: August 2017

Anti-infective potential of a polyherbal ayurvedic formulation namelypanchvalkalwas assayed against three pathogenic bacteria. This formulation was found to exert quorum-modulatory effect onChromobacterium violaceum,Serratia marcescens, andStaphylococcus aureusat 250-750 μg/mL. Besides altering production of the quorum sensing-regulated pigments in these bacteria, the test formulation also hadin vitroeffect on antibiotic susceptibility, catalase activity and hemolytic potential of the pathogens.In vivoassay confirmed the protective effect of thispanchvalkalformulation onCaenorhabditis elegans, when challenged with the pathogenic bacteria. Repeated exposure ofS. aureustopanchvalkaldid not induce resistance in this bacterium. To the best of our awareness, this the first report on quorum-modulatory potential ofpanchvalkalformulation, validating the anti-infective potential and moderate prebiotic property of this polyherbal preparation.
Convex Optimized Population Receptive Field (CO-pRF) Mapping
Authors: Slater David , Melie-Garcia Lester , Adaszewski Stanislaw , Kay Kendrick , Lutti Antoine , Draganski Bogdan , Kherif Ferath
Published: August 2017

Population receptive field (pRF) mapping represents an invaluable non-invasive tool for the study of sensory organization and plasticity within the human brain. Despite the very appealing result that fMRI derived pRF measures agree well with measurements made from other fields of neuroscience, current techniques often require very computationally expensive non-linear optimization procedures to fit the models to the data which are also vulnerable to bias due local minima issues. In this work we present a general framework for pRF model estimation termed Convex Optimized Population Receptive Field (CO-pRF) mapping and show how the pRF fitting problem can be linearized in order to be solved by extremely fast and efficient algorithms. The framework is general and can be readily applied to a variety of pRF models and measurement schemes. We provide an example of the CO-pRF methodology as applied to a computational neuroimaging approach used to map sensory processes in human visual cortex - the CSS-pRF model. Via simulation and in-vivo fMRI results we demonstrate that the CO-pRF approach achieves robust model fitting even in the presence of noise or reduced data, providing parameter estimates closer to the global optimum across 93% of in-vivo responses as compared to a typical nonlinear optimization procedure. Furthermore the example CO-pRF application substantially reduced model fitting times by a factor of 50. We hope that the availability of such highly accelerated and reliable pRF estimation algorithms will facilitate the spread of pRF techniques to larger imaging cohorts and the future study of neurological disorders and plasticity within the human brain.
Polymorphism of a widely used building block for halogen-bonded assemblies: 1,3,5-trifluoro-2,4,6-triiodobenzene
Authors: Raffo Pablo A. , Suárez Sebastián , Fantoni Adolfo C. , Baggio Ricardo , Cukiernik Fabio D.
Published: August 2017

After reporting the structure of a new polymorph of 1,3,5-trifluoro-2,4,6-triiodobenzene (denoted BzF3I3), C6F3I3, (I), which crystallized in the space group P21/c, we perform a comparative analysis with the already reported P21/n polymorph, (II) [Reddy et al. (2006). Chem. Eur. J.
12, 2222–2234]. In polymorph (II), type-II I...I halogen bonds and I...π interactions connect molecules in such a way that a three-dimensional structure is formed; however, the way in which molecules are connected in polymorph (I), through type-II I...I halogen bonds and π–π interactions, gives rise to an exfoldable lamellar structure, which looks less tightly bound than that of (II). In agreement with this structural observation, both the melting point and the melting enthalpy of (I) are lower than those of (II).
Questioning worth: selling out in the music industry
Authors: Bridson Kerrie , Evans Jody , Varman Rohit , Volkov Michael , McDonald Sean
Published: August 2017

Purpose

This study aims to illuminate the way in which consumers question the authenticity and worth of musicians, leading to a classification of selling out. The authors contribute to the debate on authenticity by attending to the question of worth that is under-examined in existing literature, by drawing upon French pragmatic sociology with specific attention to convention theory to understand conflicting interpretations of worth.

Design/methodology/approach

The considerations music fans go through navigating whether artists are selling out and the loss of worth were explored through 22 semi-structured interviews, complemented by focus group discussions (20 participants) and analysis of an online video blog.

Findings

The study identified three key themes: “Authenticity and Worth in the Inspired World”, “Selling Out as Loss of Worth” and “Signifiers of Selling Out”.

Practical implication

The emergent themes enable us to understand the worth that consumers place on musical artists, and the clash between the ideologies of the market world and the inspired world. The ideas regarding selling out and the signifiers may apply to other consumption experiences where the clash between the inspired and the market worlds exists and the conflicting ethos of each can lead to a loss of worth and selling out.

Originality/value

In this research, the authors examine situations in which consumers stigmatise as “sell outs”, artists who are marketised under the influence of capitalist social relations of production. As a result, these artists lose their authenticity and worth in the eyes of consumers. In doing so, this research contributes to the debate on authenticity by attending to the question of worth that is under-examined in existing literature.
Domain-specific market segmentation using a latent class mixture modelling approach and wine-related lifestyle (WRL) algorithm
Authors: Bruwer Johan , Li Elton
Published: August 2017

Purpose

Since the publication of Van Raaij and Verhallen’s seminal work in European Journal of Marketing in 1994, identifying the domain-specific market segmentation approach as one of the most feasible for segmenting markets, there has been surprisingly limited development in this field, with the food domain as the only exception. This study aims to develop a methodological approach using latent class mixture modelling as contribution in the domain-specific market segmentation field.

Design/methodology/approach

This study captures the AIO lifestyle perspective using a domain-specific 80-item algorithm which has the wine (product) domain as its focus. A sample size of 811 consumers is used from data collected by means of the CATI approach.

Findings

The authors use four criteria for model selection: comparison of the Bayesian information criterion (BIC) statistic, comparison of classification error, verification of the interpretation of the derived segments and, finally, use of the conditional bootstrap procedure to test whether the selected model provides a significant improvement over the previous model. The five-segment model option yields a minimum BIC, the classification error measure is minimal and is easier to interpret than the other models. Segment descriptions for the five identified lifestyle-based segments are developed.

Research limitations/implications

Segmentation by traditional k-means clustering has proven to be less useful than the more innovative alternative of mixture regression modelling; therefore, the authors identify segments in the market on the basis of individuals’ domain-specific lifestyle characteristics using a latent class mixture modelling approach.

Practical implications

Following the attainment of a clear and robust market segmentation structure, the simultaneous analysis of the lifestyles, demographics and behaviours of consumers as nexus of the domain-specific segmentation approach, provides rich and valid information accurately informing the market segment descriptions.

Originality/value

The authors make a substantive contribution by developing a methodological approach using latent class mixture modelling; the first of its kind in the area of domain-specific segmentation. Next, they use the discriminant and/or predictive validity of the 80-scale items to predict cluster membership using the WRL algorithm. Finally, the authors describe the identified market segments in detail and outline the practical implications.
Library staff recruitment and retention for managerial positions in Vietnam
Authors: Huynh Trang Thi
Published: August 2017

Purpose

This paper aims to conduct an exploratory research of recruitment source and professional staff retention for succession planning, as well as suggests some experiences of keeping qualified staff in Vietnamese libraries. It stems from the context of academic and public libraries in the Mekong Delta region, Vietnam.

Design/methodology/approach

This research draws on transformational leadership theory initiated by Burns (1978) and expanded by Bass (1985). It was conducted through a multi-method case study approach at 13 public and 4 academic libraries in the Mekong Delta, Vietnam. Data collection consisted of an online survey with 162 responses and 23 in-depth semi-structured interviews.

Findings

Research result indicates that staff recruitment for managerial positions in Vietnamese libraries is mainly from within the organisation. Staff retention relies on differing factors, of which salary was considered the most important by several participants. However, succession planning itself may be a good way to keep qualified employees who would like to be promoted. For those employees attracted by high salaries rather than future managerial positions, supplemental income is believed to be a possible solution.

Research limitations/implications

A larger research coverage will be suggested to further research, so as to get further information about staff recruitment and how to retain qualified staff in Vietnamese library settings.

Practical implications

This study aims to benefit library leaders by providing good insights into which recruitment source is suitable to look for qualified staff for managerial positions in Vietnam. Most importantly, the research would inform library leaders and the local government in the Mekong Delta of the possible reasons for staff turnover. This study also helps to raise library leaders’ awareness of how to retain their qualified professional employees within a highly dynamic environment.

Originality/value

This research contributes to literature about qualified staff recruitment and retention in an Asian country context, which has not been discussed so far. It also helps to raise awareness of library leaders about applying some practical strategies, including succession planning, into retaining managing employees in their organisations.
F1000: an overview and evaluation
Authors: Williams Ann E.
Published: August 2017

Purpose

The purpose of this paper is to provide an overview and evaluation of F1000, a publishing outlet and peer review system for research in the biomedical and life sciences.

Design/methodology/approach

The review chronicles the rise of F1000 and describes the site’s functionalities and use capabilities.

Findings

The findings detail both the strengths and limitations of F1000 and point toward avenues for continued research and development.

Originality/value

This is the first review to provide a substantive evaluation of F1000 for academics to consider when adopting, using and researching the platform.
hybriddetective: A workflow and package to facilitate the detection of hybridization using genomic data in r
Authors: Wringe Brendan F. , Stanley Ryan R. E. , Jeffery Nicholas W. , Anderson Eric C. , Bradbury Ian R.
Published: August 2017

The ability to detect and characterize hybridization in nature has long been of interest to many fields of biology and often has direct implications for wildlife management and conservation. The capacity to identify the presence of hybridization, and quantify the numbers of individuals belonging to different hybrid classes, permits inference on the magnitude of, and timescale over which, hybridization has been or is occurring. Here, we present an r package and associated workflow developed for the detection, with estimates of efficiency and accuracy, of multigenerational hybrid individuals using genetic or genomic data in conjunction with the program newhybrids. This package includes functions for the identification and testing of diagnostic panels of markers, the simulation of multigenerational hybrids, and the quantification and visualization of the efficiency and accuracy with which hybrids can be detected. Overall, this package delivers a streamlined hybrid analysis platform, providing improvements in speed, ease of use and repeatability over current ad hoc approaches. The latest version of the package and associated documentation are available on GitHub (https://github.com/bwringe/hybriddetective).
Prematurity and neonatal outcome including congenital malformations after maternal malignancy within six months prior to or during pregnancy
Authors: Sabeti Rad Zahra , Friberg Britt , Henic Emir , Rylander Lars , Ståhl Olof , Källén Bengt , Lingman Göran
Published: August 2017

Introduction

The proportion of women who postpone childbearing is increasing. As malignancy risk increases with age, pregnancy in connection with malignancy will become more common.

Material and methods

We compared infants born 1994–2011 to women with a malignancy within six months prior to the last menstrual period or during pregnancy with offspring of women without a previous malignancy. Five national registers were used.

Results

A total of 790 women with a malignancy diagnosis from six months prior to the last menstrual period up to delivery were identified. Their 802 infants were compared with 1 742 757 infants of women without a malignancy. A high rate of prematurity was found, especially when the malignancy was diagnosed during the second or third trimesters (33%). Most of these premature births were the result of induced delivery before 35 weeks (91%). The most remarkable finding is the observation that these premature infants had a significantly higher risk for neonatal morbidity than premature infants in the control group with an adjusted odds ratio of 2.67 (95% confidence interval; 1.86–3.84). We found a significantly increased risk of mainly relatively mild malformations among infants of women with a malignancy diagnosis within six months prior to the last menstrual period or during the first trimester with a risk ratio of 1.81 (95% confidence interval; 1.20–2.61).

Conclusions

A high incidence of prematurity, mostly due to induced delivery, was found, including an increased risk for neonatal morbidity among these infants. An increased risk for relatively mild malformations was also found.
Editorial: depression in the setting of inflammatory bowel disease means we have failed to provide early, effective, psychosocial care—authors’ reply
Authors: Alexakis C. , Kumar S. , Saxena S. , Hotopf M. , Pollok R.
Published: August 2017

Linked Content

This article is linked to Alexakis and Kumar and Keefer papers. To view these articles visit https://doi.org/10.1111/apt.14171 and https://doi.org/10.1111/apt.14212.
Editorial: progress towards a simple tool for screening for hepatic steatosis in the general population – authors’ reply
Authors: Yip T. C.‐F. , Ma A. J. , Yuen P.‐C. , Wong G. L.‐H.
Published: August 2017

Linked Content

This article is linked to Maj and Wong and Gallacher and McPherson papers. To view these articles visit https://doi.org/10.1111/apt.14172 and https://doi.org/10.1111/apt.14217.
Serous‐lined, stapled pouch wall plication: initial results of a simple and quick novel continence mechanism in troubleshooting secondary to continent cutaneous urinary diversion
Authors: Riedmiller Hubertus , Kocot Arkadius , Kalogirou Charis
Published: August 2017

Objectives

To report a novel and straightforward technique of a secondary continent outlet for continent cutaneous urinary diversion (CCUD) reservoirs without the need for further bowel resection, reducing operating time and length of hospitalization.

Patients and Methods

From 2015 to 2017, six patients with unreconstructable, incontinent outlets (out of a total pool of 595 patients with CCUD) have undergone the technique described in the present paper at our department. The technique relies on the Mitrofanoff principle, using a stapled full‐thickness pouch wall plication, which creates a flap‐valve continence mechanism.

Results

All patients enjoyed full continence with ease of clean intermittent catheterization (CIC) in the postoperative period and on follow‐up to a mean (range) of 12.4 (7–18) months. No major complications were encountered in any patient and the average capacity of the reservoirs was not compromised by the procedure (540 mL preoperatively vs 500 mL in further follow‐up).

Conclusion

In revisional surgery for secondary CCUD incontinence, especially if the patient has already lost a significant amount of bowel or has previously undergone radiation therapy, the technique described here represents a safe and effective alternative to restore continence.
Longitudinal vocabulary development in Australian urban Aboriginal children: Protective and risk factors
Authors: Short K. , Eadie P. , Descallar J. , Comino E. , Kemp L.
Published: August 2017

Background

Vocabulary is a key component of language that can impact on children's future literacy and communication. The gap between Australian Aboriginal and non‐Aboriginal children's reading and academic outcomes is well reported and similar to Indigenous/non‐Indigenous gaps in other nations. Determining factors that influence vocabulary acquisition over time and may be responsive to treatment is important for improving Aboriginal children's communication and academic outcomes.

Aim

To determine what factors influence Australian urban Aboriginal children's receptive vocabulary acquisition and whether any of these are risks or protective for vocabulary development.

Method

One hundred thirteen Aboriginal children in South Western Sydney from the longitudinal birth cohort Gudaga study were assessed on The Peabody Picture Vocabulary Test multiple times: 3 years, just prior to school entry, at the end of the first and second years of formal schooling. Multilevel models were used to determine the effects of 13 fixed and manipulable maternal, child, and family variables drawn from previous research.

Results

Higher maternal education was found to be protective at 3 years and over time. The number of children in urban Australian Aboriginal households made an impact on vocabulary development and this varied over time. From 3 to 6 years, those with early poor non‐verbal cognitive skills had vocabulary skills that remained below those with stronger non‐verbal skills at 3 years. Girls exhibit an earlier advantage in vocabulary acquisition, but this difference is not sustained after 4 years of age.

Conclusions

The risk and protective factors for vocabulary development in Australian Aboriginal children are similar to those identified in other studies with some variation related to the number of children in the home. In this limited set of predictors, maternal education, gender, non‐verbal cognitive skills, and the number of children in households were all shown to impact on the acquisition of vocabulary to 3 years and or the developmental trajectory over time.
Exposure to overprotective parenting and psychopathology in extremely low birth weight survivors
Authors: Day K. L. , Dobson K. G. , Schmidt L. A. , Ferro M. A. , Saigal S. , Boyle M. H. , Van Lieshout R. J.
Published: August 2017

Background

Extremely low birth weight (ELBW; <1,000 g) infants are the most vulnerable babies and are at higher risk for experiencing overprotective (i.e., controlling and intrusive) parenting, which is hypothesized to contribute to the risk for mental disorders. Despite the increased risk for anxiety disorders and decreased risk for alcohol or substance use disorders seen in ELBW survivors, no research has examined the impact of parenting. This study investigated if overprotective parenting mediates links between ELBW birth status and psychiatric disorders in adulthood.

Study design

Participants included ELBW survivors born in 1977–1982 and matched normal birth weight (≥2,500 g) control participants (ELBW n = 81; normal birth weight n = 87) prospectively followed in Ontario, Canada. These individuals retrospectively reported on whether either of their parents was overprotective using the Parental Bonding Instrument. Presence of a current anxiety disorder and of current alcohol or substance use disorders was assessed using the Mini International Neuropsychiatric Interview at age 29–36 years.

Results

Path analysis showed that overprotective parenting was a significant mediator of the association between ELBW status and risk for an anxiety disorder in adulthood and the risk for an alcohol or substance use disorder in adulthood in ELBW survivors. Overprotective parenting accounted for 53% of the association between ELBW status and the risk for an anxiety disorder in adulthood and 26% of the association between ELBW status and alcohol or substance use disorders.

Conclusions

Overprotective parenting accounted for a substantial proportion of the increased risk for anxiety and alcohol or substance use disorders in adulthood in ELBW survivors. Despite their perceived vulnerabilities, it is important that the parents of ELBW survivors be supported in their attempts to facilitate their children's pursuit of independence during childhood and beyond.
Diagnosis of monogenic liver diseases in childhood by next‐generation sequencing
Authors: Stalke A. , Skawran B. , Auber B. , Illig T. , Schlegelberger B. , Junge N. , Goldschmidt I. , Leiskau C. , von Neuhoff N. , Baumann U. , Pfister E.‐D.
Published: August 2017

Next‐generation sequencing (NGS) has opened up novel diagnostic opportunities for children with unidentified, but suspected inherited diseases. We describe our single‐center experience with NGS diagnostics in standard clinical scenarios in pediatric hepatology. We investigated 135 children with suspected inherited hepatopathies, where initially no causative pathogenic variant had been identified, with an amplicon‐based NGS panel of 21 genes associated with acute and chronic hepatopathies. In 23 of these patients, we detected pathogenic or likely pathogenic variants in 10 different genes. We present 6 novel variants. A total of 14 of these patients presented with the characteristic phenotype of the related hepatopathy. Nine patients showed only few or atypical clinical symptoms or presented with additional signs. In another 13 out of 135 cases, we detected variants of unknown significance (VUS) in 9 different genes. Only 2 of these patients showed characteristic phenotypes conclusive with the detected variants, whereas 11 patients showed unspecific or atypical phenotypes. Our multi‐gene panel is a fast and comprehensive tool to diagnose inherited pediatric hepatopathies. We also illustrate the challenge of dealing with genetic variants and highlight arising clinical questions, especially in patients with atypical phenotypes.