bluuebunny/crossref_metadata_2025 huggingface dataset:
The Potential Threats of Spodoptera frugiperda on Six Economic Tree Species in the Tropical Region
Authors: Xue Jiabao , Chen Yi , Kong Xiangyi , Jia Ruizong , Jiang Xiaoqi , Guo Jingyuan , Guo Yunling , Yang Yan
Published: April 2024

Spodoptera frugiperda (J.E. Smith) is a highly significant agricultural pest that poses a threat to crop production worldwide. It is polyphagous, has a strong migratory ability, and is difficult to control, which makes it a threat not only to crops but also to woody plants. However, research on its adaptability to woody plants is limited. This study compares the feeding adaptations (survival rate, pupation time, pupation rate, weight, length, and daily food consumption), protective enzyme activities, and feeding preferences of S. frugiperda on leaves of six economically important tree species (Areca catechu L., Aquilaria sinensis (Lour.) Spreng, Cocos nucifera L., Camellia oleifera Abel, Dalbergia odorifera T. Chen, and Hevea brasiliensis (Willd. ex A. Juss.) Müll. Arg.), with Zea mays L. used as a control treatment. The results indicate that S. frugiperda did not survive when fed with A. catechu, C. oleifera, and D. odorifera. A. catechu had similar survival rates (83.33%), pupation (86.67%), weight, and length data compared to the maize control. C. nucifera had lower survival rates (46.67%) but no significant differences in pupation (76.67%), weight, and length data of S. frugiperda. H. brasiliensis exhibited significantly lower survival (50.00%) and pupation rates (46.67%) compared to maize. However, there was no significant difference in weight and length data, and its preference index was higher among the six tree species treatments. Therefore, A. sinensis is a vulnerable tree with a high risk, while H. brasiliensis and C. nucifera showed varying degrees of susceptibility. A. catechu, C. oleifera, and D. odorifera were found to be unsuitable hosts for S. frugiperda. In conclusion, this study extensively explores the feeding effects of S. frugiperda on six economically important tree species. It provides insights into the feeding preferences of the pest, thereby informing the potential threat posed by S. frugiperda to economically important trees. It helps to prevent further damage from S. frugiperda and provides a reference for agriculture and forestry to develop effective joint prevention and control measures.
Exploring Conspiracist Populism in Power: The Case of Kais Saied in Tunisia
Authors: Annovi Claudia
Published: April 2024

The aim of this paper is to conduct a literature review of the existing nexus between conspiracy theories and populist politics. Most of the literature considering the political nature of conspiracy theories has focused mainly on individual action and electoral choices, hence setting aside the agency of political leaders that deliberately resort to these tales to mobilise supporters. On the contrary, conspiracy theories are increasingly moving away from extremist politics to enter the institutional political arena and become part and parcel of the political narratives and strategies of institutional figures. Against this backdrop, the present work offers a new approach to investigate the connection between populist conspiracy theories and conspiracist populism and attempts to explain how conspiracist populism works and what its potential impact on contemporary democracies is. The analysis of the literature offers some theoretical insights to explore the specific case of the presidency of Kais Saied in Tunisia, which has been labelled as a form of constitutional populism integrating conspiracy theories. The inquiry on the Tunisian case demonstrates that conspiracy theories can represent both tactics and framings for populists in power, and, if democratic checks and balances are weak enough, they can lead to the erosion of democracy itself.
Neurofilaments in Sporadic and Familial Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
Authors: Shahim Pashtun , Norato Gina , Sinaii Ninet , Zetterberg Henrik , Blennow Kaj , Chan Leighton , Grunseich Christopher
Published: April 2024

Background: Neurofilament proteins have been implicated to be altered in amyotrophic lateral sclerosis (ALS). The objectives of this study were to assess the diagnostic and prognostic utility of neurofilaments in ALS. Methods: Studies were conducted in electronic databases (PubMed/MEDLINE, Embase, Web of Science, and Cochrane CENTRAL) from inception to 17 August 2023, and investigated neurofilament light (NfL) or phosphorylated neurofilament heavy chain (pNfH) in ALS. The study design, enrolment criteria, neurofilament concentrations, test accuracy, relationship between neurofilaments in cerebrospinal fluid (CSF) and blood, and clinical outcome were recorded. The protocol was registered with PROSPERO, CRD42022376939. Results: Sixty studies with 8801 participants were included. Both NfL and pNfH measured in CSF showed high sensitivity and specificity in distinguishing ALS from disease mimics. Both NfL and pNfH measured in CSF correlated with their corresponding levels in blood (plasma or serum); however, there were stronger correlations between CSF NfL and blood NfL. NfL measured in blood exhibited high sensitivity and specificity in distinguishing ALS from controls. Both higher levels of NfL and pNfH either measured in blood or CSF were correlated with more severe symptoms as assessed by the ALS Functional Rating Scale Revised score and with a faster disease progression rate; however, only blood NfL levels were associated with shorter survival. Discussion: Both NfL and pNfH measured in CSF or blood show high diagnostic utility and association with ALS functional scores and disease progression, while CSF NfL correlates strongly with blood (either plasma or serum) and is also associated with survival, supporting its use in clinical diagnostics and prognosis. Future work must be conducted in a prospective manner with standardized bio-specimen collection methods and analytical platforms, further improvement in immunoassays for quantification of pNfH in blood, and the identification of cut-offs across the ALS spectrum and controls.
Evaluating the Credibility and Reliability of Online Information on Cannabidiol (CBD) for Epilepsy Treatment in Poland
Authors: Zakrzewski Dawid M. , Podlejska Patrycja , Kubziakowska Wiktoria , Dzwilewski Kamil , Waszak Przemysław M. , Zawadzka Marta , Mazurkiewicz-Bełdzińska Maria
Published: April 2024

The interest in the potential therapeutic use of cannabis, especially cannabidiol (CBD), has increased significantly in recent years. On the Internet, users can find lots of articles devoted to its medical features such as reducing seizure activity in epilepsy. The aim of our work was to evaluate the information contained on the websites, including social media, in terms of the credibility and the reliability of current knowledge about the usage of products containing cannabidiol in epilepsy treatment. We used online available links found using the Newspointtool. The initial database included 38,367 texts, but after applying the inclusion and exclusion criteria, 314 texts were taken into consideration. Analysis was performed using the DISCERN scale and the set of questions created by the authors. In the final assessment, we observed that most of the texts (58.9%) were characterized by a very poor level of reliability and the average DISCERN score was 26.97 points. Additionally, considering the form of the text, the highest average score (35.73) came from entries on blog portals, whereas the lowest average score (18.33) came from comments and online discussion forums. Moreover, most of the texts do not contain key information regarding the indications, safety, desired effects, and side effects of CBD therapy. The study highlights the need for healthcare professionals to guide patients towards reliable sources of information and cautions against the use of unverified online materials, especially as the only FDA-approved CBD medication, Epidiolex, differs significantly from over-the-counter CBD products.
Pumping up the Fight against Multiple Sclerosis: The Effects of High-Intensity Resistance Training on Functional Capacity, Muscle Mass, and Axonal Damage
Authors: Maroto-Izquierdo Sergio , Mulero Patricia , Menéndez Héctor , Pinto-Fraga José , Lista Simone , Santos-Lozano Alejandro , Téllez Nieves
Published: April 2024

Background: Resistance training (RT) has been recognized as a beneficial non-pharmacological intervention for multiple sclerosis (MS) patients, but its impact on neurodegeneration is not fully understood. This study aimed to investigate the effects of high-intensity RT on muscle mass, strength, functional capacity, and axonal damage in MS patients. Methods: Eleven relapsing–remitting MS patients volunteered in this within-subject counterbalanced intervention study. Serum neurofilament light-chain (NfL) concentration, vastus lateralis thickness (VL), timed up-and-go test (TUG), sit-to-stand test (60STS), and maximal voluntary isometric contraction (MVIC) were measured before and after intervention. Participants performed 18 sessions of high-intensity RT (70–80% 1-RM) over 6 weeks. Results: Significant (p < 0.05) differences were observed post-intervention for VL (ES = 2.15), TUG (ES = 1.98), 60STS (ES = 1.70), MVIC (ES = 1.78), and NfL (ES = 1.43). Although moderate correlations between changes in VL (R = 0.434), TUG (R = −0.536), and MVIC (R = 0.477) and changes in NfL were observed, only the correlation between VL and MVIC changes was significant (R = 0.684, p = 0.029). Conclusions: A 6-week RT program significantly increased muscle mass, functional capacity, and neuromuscular function while also decreasing serum NfL in MS patients. These results suggest the effectiveness of RT as a non-pharmacological approach to mitigate neurodegeneration while improving functional capacity in MS patients.
An Opportunity to Fill a Gap for Newborn Screening of Neurodevelopmental Disorders
Authors: Chung Wendy K. , Kanne Stephen M. , Hu Zhanzhi
Published: April 2024

Screening newborns using genome sequencing is being explored due to its potential to expand the list of conditions that can be screened. Previously, we proposed the need for large-scale pilot studies to assess the feasibility of screening highly penetrant genetic neurodevelopmental disorders. Here, we discuss the initial experience from the GUARDIAN study and the systemic gaps in clinical services that were identified in the early stages of the pilot study.
Inflammatory Cells in Adipose Tissue and Skeletal Muscle of Patients with Peripheral Arterial Disease or Chronic Venous Disease: A Prospective, Observational, and Histological Study
Authors: Ferreira Joana , Longatto-Filho Adhemar , Afonso Julieta , Roque Susana , Carneiro Alexandre Lima , Vila Isabel , Silva Cristina , Cunha Cristina , Mesquita Amílcar , Cotter Jorge , Correia-Neves Margarida , Mansilha Armando , Cunha Pedro
Published: April 2024

The main goal of this study was to assess whether the presence of peripheral arterial disease (PAD) correlates with increased inflammatory cell infiltration. An observational, single-centre, and prospective study was conducted from January 2018 to July 2022. Clinical characteristics and anthropometric measures were registered. Consecutive PAD patients with surgical indications for a common femoral artery approach and patients with varicose veins with an indication for surgical ligation of the saphenofemoral junction were included. In both groups, samples of sartorius skeletal muscle, subcutaneous adipose tissue (SAT), and perivascular adipose tissue (PVAT) were collected from the femoral region. We analysed the characteristics of adipocytes and the presence of haemorrhage and inflammatory cells in the samples of PVAT and SAT via haematoxylin–eosin staining. We found that patients with PAD had significantly more inflammatory cells in PVAT [16 (43.24%) vs. 0 (0%) p = 0.008]. Analysing SAT histology, we observed that patients with PAD had significantly more CD45+ leucocytes upon immunohistochemical staining [32 (72.73%) vs. 3 (27.27%) p = 0.005]. Upon analysing skeletal muscle histology with haematoxylin–eosin staining, we evaluated skeletal fibre preservation, as well as the presence of trauma, haemorrhage, and inflammatory cells. We registered a significantly higher number of inflammatory cells in patients with PAD [well-preserved skeletal fibres: PAD = 26 (63.41%) vs. varicose veins = 3 (37.50%) p = 0.173; trauma: PAD = 4 (9.76%) vs. varicose veins = 2 (25.00%) p = 0.229; haemorrhage: PAD = 6 (14.63%) vs. varicose veins = 0 (0%) p = 0.248; inflammatory cells: PAD = 18 (43.90%) vs. varicose veins = 0 (0%) p = 0.018]. Patients with PAD had a higher number of inflammatory cells in skeletal muscle and adipose tissue (PVAT and SAT) when compared with those with varicose veins, emphasizing the role of inflammation in this group of patients.
Hidden Treasure: Halophilic Fungi as a Repository of Bioactive Lead Compounds
Authors: Agrawal Shivankar , Chavan Pruthviraj , Dufossé Laurent
Published: April 2024

The pressing demand for novel compounds to address contemporary health challenges has prompted researchers to venture into uncharted territory, including extreme ecosystems, in search of new natural pharmaceuticals. Fungi capable of tolerating extreme conditions, known as extremophilic fungi, have garnered attention for their ability to produce unique secondary metabolites crucial for defense and communication, some of which exhibit promising clinical significance. Among these, halophilic fungi thriving in high-salinity environments have particularly piqued interest for their production of bioactive molecules. This review highlights the recent discoveries regarding novel compounds from halotolerant fungal strains isolated from various saline habitats. From diverse fungal species including Aspergillus, Penicillium, Alternaria, Myrothecium, and Cladosporium, a plethora of intriguing molecules have been elucidated, showcasing diverse chemical structures and bioactivity. These compounds exhibit cytotoxicity against cancer cell lines such as A549, HL60, and K-562, antimicrobial activity against pathogens like Escherichia coli, Bacillus subtilis, and Candida albicans, as well as radical-scavenging properties. Notable examples include variecolorins, sclerotides, alternarosides, and chrysogesides, among others. Additionally, several compounds display unique structural motifs, such as spiro-anthronopyranoid diketopiperazines and pentacyclic triterpenoids. The results emphasize the significant promise of halotolerant fungi in providing bioactive compounds for pharmaceutical, agricultural, and biotechnological uses. However, despite their potential, halophilic fungi are still largely unexplored as sources of valuable compounds.
Understanding the Adoption Dynamics of ChatGPT among Generation Z: Insights from a Modified UTAUT2 Model
Authors: Biloš Antun , Budimir Bruno
Published: April 2024

This research delves into the factors influencing the adoption of ChatGPT, a sophisticated AI-based chatbot, among Generation Z members in Croatia. Employing an extended UTAUT2 model, the impact of various factors on the behavioral intention to use ChatGPT is explored. The study included 694 Generation Z participants, and data were collected through an online survey featuring self-reporting questions. The analysis utilized statistical software packages for performing both confirmatory and exploratory factor analyses, in addition to hierarchical linear regression. Key findings reveal that performance expectancy, social influence, hedonic motivation, habit, and personal innovativeness significantly influence the behavioral intention to use ChatGPT. However, effort expectancy, facilitating conditions, and price value do not exhibit a significant impact. Notably, the study excludes the use behavior factor due to multicollinearity issues with behavioral intention. While the research does not focus on moderating factors, it reports that the adapted UTAUT2 model explains 65% of the variance in the adoption of ChatGPT by Generation Z users.
Lifetime Distribution for a Mixed Redundant System with Imperfect Switch and Components Having Phase–Type Time-to-Failure Distribution
Authors: Baek Myung-Ki , Kim Heungseob
Published: April 2024

Recently, a mixed redundancy was introduced among the redundant design strategies to achieve a more reliable system within the equivalent resources. This study deals with a lifetime distribution for a mixed redundant system with an imperfect fault detector/switch. The lifetime distribution model was formulated using a structured continuous Markov chain (CTMC) and considers the time-to-failure (TTF) distribution of a component as a phase-type distribution (PHD). The model’s versatility and practicality are enhanced because the PHD can represent diverse degradation patterns of the components exposed to varied operating environments. The model provides accurate reliability for a mixed redundant system by advancing the approximate reliability function suggested in previous studies. Furthermore, the model would be useful in system design and management because it provides information such as the nth moment of the system’s lifetime distribution. In numerical experiments on some examples, the mixed redundancy was confirmed to devise a more reliable system than the existing active and standby redundancies, and the improvement effect increased as the number of redundant components decreased. The optimal structure for maximizing the expected lifetime of the system changes depends on the reliability of the components and fault detector/switch.
A Compact Millimeter-Wave Multilayer Patch Antenna Array Based on a Mixed CPW-Slot-Couple Feeding Network
Authors: Deng Kun , Zhang Naibo , Yang Guangyao , Li Yitong , Song Ruiliang , Liu Ning
Published: April 2024

A compact Ka-band antenna array has been proposed to realize broadband and high gain for millimeter-wave applications. The antenna array is divided into a multilayer composed of a driven slot patch layer and a parasitic patch array layer, which is excited by a mixed CPW-Slot-Couple feeding network layer. According to characteristic mode analysis, a pair of narrow coupling slots are introduced in the driven patch to move the resonant frequency of characteristic mode 3 to the resonant frequency of characteristic mode 2 for enhanced bandwidth. In this article, a 1to4 CPW-Slot-Couple feeding network for a 2 × 2 driven slot patch array is implemented, and then each driven slot patch excites a 2 × 2 parasitic patch array. Finally, a proposed 4 × 4 × 3 (row × column × layer) Ka-band antenna array is fabricated to verify the design concepts. The measured results show that the frequency bandwidth of the antenna array is 25 GHz to 32 GHz, and the relative bandwidth is 24.5%. The peak gain is 20.1 dBi. Due to its attractive properties of miniaturization, broadband, and high gain, the proposed antenna array could be applied to millimeter-wave wireless communication systems.
Comparative Effect of Seed Coating and Biopriming of Bacillus aryabhattai Z-48 on Seedling Growth, Growth Promotion, and Suppression of Fusarium Wilt Disease of Tomato Plants
Authors: Akram Waheed , Waqar Sara , Hanif Sana , Anjum Tehmina , Aftab Zill-e-Huma , Li Guihua , Ali Basharat , Rizwana Humaira , Hassan Ali , Rehman Areeba , Munir Bareera , Umer Muhammad
Published: April 2024

Beneficial plant microbes can enhance the growth and quality of field crops. However, the benefits of microbes using cheap and efficient inoculation methods are still uncommon. Seed coating with biocontrol agents can reduce the amount of inocula along with having the potential for large-scale application. Hence, in this research work, the comparative potential of tomato seed coating and biopriming with Bacillus aryabhattai Z-48, harboring multiple plant-beneficial traits, to suppress Fusarium wilt disease along with its beneficial effect on seedling and plant growth promotion was analyzed. Among two bacterial strains, B. aryabhattai Z-48 was able to antagonize the mycelial growth of Fusarium oxysporum f.sp. lycopersici in vitro and its application as a seed coating superiorly benefited seedling traits like the germination percentage, vigor index, and seedling growth index along with a reduced germination time. The seed coating with B. aryabhattai Z-48 resulted in significant increases in the shoot length, root length, dry biomass, and total chlorophyll contents when compared with the bioprimed seeds with the same bacterial strain and non-inoculated control plants. The seed coating with B. aryabhattai Z-48 significantly reduced the disease index (>60%) compared with the pathogen control during pot trials. Additionally, the seed coating with B. aryabhattai Z-48 resulted in a significantly higher production of total phenolics, peroxidase, polyphenol oxidase, and phenylalanine ammonia lyase enzyme in tomato plants. The GC/MS-based non-targeted metabolic profiling indicated that the seed coating with B. aryabhattai Z-48 could cause large-scale metabolite perturbations in sugars, sugar alcohols, amino acids, and organic acids to increase the fitness of tomato plants against biotic stress. Our study indicates that a tomato seed coating with B. aryabhattai Z-48 can improve tomato growth and suppress Fusarium wilt disease effectively under conventional agricultural systems.
Freshwater and Marine Environments in California Are a Reservoir of Carbapenem-Resistant Bacteria
Authors: McCarley Ashley , Espejo Manuel Luis , Harmon Dana E. , Ruiz Cristian
Published: April 2024

Carbapenems are last-resort antibiotics used to treat multidrug-resistant bacterial infections. Resistance to carbapenems has been designated as an urgent threat and is increasing in healthcare settings. However, little is still known about the distribution and characteristics of carbapenem-resistant bacteria (CRB) outside of healthcare settings. Here, we surveyed the distribution of CRB in ten diverse freshwater and seawater environments in California, U.S., ranging from San Luis Obispo County to San Bernardino County, combining both direct isolation and enrichment approaches to increase the diversity of isolated CRB. From the locations surveyed, we selected 30 CRB for further characterization. These isolates were identified as members of the genera Aeromonas, Enterobacter, Enterococcus, Paenibacillus, Pseudomonas, Sphingobacterium, and Stenotrophomonas. These isolates were resistant to carbapenems, other β-lactams, and often to other antibiotics (tetracycline, gentamicin, or ciprofloxacin). We also found that nine isolates belonging to the genera Aeromonas, Enterobacter (blaIMI-2), and Stenotrophomonas (blaL1) produced carbapenemases. Overall, our findings indicate that sampling different types of aquatic environments and combining different isolation approaches increase the diversity of the environmental CRB obtained. Moreover, our study supports the increasingly recognized role of natural water systems as an underappreciated reservoir of bacteria resistant to carbapenems and other antibiotics, including bacteria carrying carbapenemase genes.
Prospects for Geological Storage of CO2 in Carbonate Formations of the Adriatic Offshore
Authors: Saftić Bruno , Bralić Nikolina , Rukavina David , Kolenković Močilac Iva , Cvetković Marko
Published: April 2024

Croatia has both significant CO2 emissions from the point sources and a history of oil and gas exploration, and this is why the CCS technology surfaced as a viable solution for curbing CO2 emissions on a national level. Since approximately half of emissions from the stationary industrial sources occur along the Adriatic coastline, the entire offshore area became an exploration target. Regional studies revealed the potential storage plays, one of which is in the aquifer of the Mesozoic carbonate complex with dual porosity extending all along the Croatian offshore area. Three structures were chosen in its central part–Klara, Kate and Perina. For the first two, the models were constructed based on the data from old exploration wells and a regional structural map, while for the Perina structure, a new seismic interpretation was added to better characterise its properties. It came out that the Kate structure appears to be the most prospective in general (45 Mt), with neighbouring Klara as the second (39 Mt), while the initially promising Perina (7 Mt) turned out to be of far lesser importance. The Perina structure case is an example that new seismic interpretation can reduce the capacity estimate if it reveals certain limiting factors, in this case, the limitation of structural closure.
Activated Carbon Derived from Cucumber Peel for Use as a Supercapacitor Electrode Material
Authors: Nazhipkyzy Meruyert , Kurmanbayeva Gulim , Seitkazinova Aigerim , Varol Esin Apaydın , Li Wanlu , Dinistanova Balaussa , Issanbekova Almagul , Mashan Togzhan
Published: April 2024

Biowaste conversion into activated carbon is a sustainable and inexpensive approach that relieves the pressure on its disposal. Here, we prepared micro-mesoporous activated carbons (ACs) from cucumber peels through carbonization at 600 °C followed by thermal activation at different temperatures. The ACs were tested as supercapacitors for the first time. The carbon activated at 800 °C (ACP-800) showed a high specific capacitance value of 300 F/g at a scan rate of 5 mV/s in the cyclic voltammetry and 331 F/g at the current density of 0.1 A/g in the galvanostatic charge–discharge analysis. At the current density of 1 A/g, the specific discharge capacitance was 286 F/g and retained 100% capacity after 2000 cycles. Their properties were analyzed by scanning electron microscopy, energy-dispersive X-ray analysis, porosity, thermal analysis, and Fourier-transform infrared spectroscopy. The specific surface area of this sample was calculated to be 2333 m2 g−1 using the Brunauer–Emmett–Teller method. The excellent performance of ACP-800 is mainly attributed to its hierarchical porosity, as the mesopores provide connectivity between the micropores and improve the capacitive performance. These electrochemical properties enable this carbon material prepared from cucumber peels to be a potential source for supercapacitor materials.
Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition
Authors: Romanowska Hanna , Wilk Aleksandra , Danko Mikołaj , Borkowska Anna , Popińska Katarzyna , Sibilska Marta , Żydak Joanna , Marciniak Wojciech , Szlagatys-Sidorkiewicz Agnieszka , Książyk Janusz
Published: April 2024

This study continues the research in which we determined the concentration of aluminum in children receiving long-term parenteral nutrition (LPN). Since our results were interesting, we decided to assay arsenic (As) and cobalt (Co) in the collected material, which, like aluminum, constitute contamination in the mixtures used in parenteral nutrition. Excesses of these trace elements in the human body are highly toxic, and deficiencies, particularly in the case of Co, can lead to various complications. The aim of this study was to determine the impact of LPN in children on their serum levels of As and Co, as well as the excretion of these elements in urine, and to compare them with a control group of healthy children. The study group consisted of 83 children receiving home parenteral nutrition from two Polish centers, while the control group included 121 healthy children. In both groups, the levels of As and Co in serum and urine were measured. The elemental compositions of the samples were determined using inductively coupled plasma mass spectrometry (ICP-MS). It was demonstrated that the children receiving LPN did not have increased As exposure compared to the controls. Greater exposure compared to the control group was shown for Co. In conclusion, children receiving LPN are not exposed to As, and even though the concentrations of Co in serum and urine were higher in the LPN group than in the healthy controls, neither trace element poses a health threat to children requiring LPN.
Diet-Induced Early Inflammatory Response of Visceral Adipose Tissue in Healthy Male Wistar Rats
Authors: Dimitrov Iliyan , Stankova Teodora , Angelova Penka , Boyadjiev Nikolay , Georgieva Katerina , Dimov Ivica , Bivolarska Anelia , Draganova Milena , Gerginska Fanka , Daskalova Elena , Gramatikov Vilian , Delchev Slavi
Published: April 2024

The prolonged consumption of a high-fat diet (HFD) leads to abnormal growth of the visceral adipose tissue (VAT), increased macrophage infiltration, and altered secretion of biologically active molecules. This is considered as a precondition for the development of obesity, inflammation, and obesity-related disorders. Therefore, we studied HFD-induced changes in the tissue levels of the inflammatory markers C-reactive protein, serum amyloid-A, and interleukin-4 in healthy male Wistar rats. The animals were first divided at random into two groups subjected to either a standard or a high-fat diet. The initial effect of the diet was evaluated after fourteen weeks. In order to study the diet duration effect, the standard diet was given to twelve animals from the HFD group, while the remaining continued with the HFD for an additional four weeks. Our results showed that the HFD barely affected body mass index, conicity, relative fat mass, and Lee indices, whereas it provoked adipocyte hypertrophy and gradually increased the levels of both the pro- and anti-inflammatory markers. The switch from the high-fat to the standard diet resulted in the comparatively fast restoration of the baseline levels of the studied molecules. Although, the prolonged consumption of an HFD causes adipocyte hypertrophy in healthy male animals, the inflammatory process in VAT is well-coordinated, time-dependent, and reversible.
Transmission Modelling for Human Non-Zoonotic Schistosomiasis Incorporating Vaccination: Guiding Decision- and Policymaking
Authors: Panzner Ursula
Published: April 2024

Schistosomiasis, acquired by skin-penetrating cercariae of dioecious digenean schistosomes during freshwater contact, afflicts nearly 260 and 440 million people with active infections and residual morbidity, respectively. About 10 million women at reproductive age contract schistosomiasis during gestation every year. Acute schistosomiasis is characterized by pre-patent pro-inflammatory CD4+ T-helper 1 or CD4+ Th1/T-helper 17 reactivity against immature schistosomulae. Chronic schistosomiasis is dominated by post-patent anti-inflammatory CD4+ T-helper 2 reactivity against ova epitopes. Flukes co-exist in immunocompetent definitive hosts as they are capable of evading their defense mechanisms. Preventive measures should be complemented by vaccination, inducing long-term protection against transmission, infection, and disease recurrence, given the latest advancements in schistosomal vaccines. Vaccines become pivotal when considering constraints of chemotherapy, i.e., lack of protection against re-infection, and evolving resistance or reduced sensitivity. Transmission models for human non-zoonotic schistosomiasis incorporating vaccination available in PubMed, Embase and Web of Science up to 31 December 2023 are presented. Besides conceptual model differences, predictions meant to guide decision- and policymaking reveal continued worm harboring that facilitates transmission besides residual infections. In addition, increased susceptibility to re-infection and rebound morbidity, both shifted to later life stages following the intervention, are forecasted. Consequently, a vaccination schedule is pivotal that considers the optimal age for initial immunization, i.e., pre-schoolchildren or schoolchildren in a cohort-based or population-based manner, while incorporating potential non-adherers promoting ongoing transmission. Longevity over magnitude of vaccine protection to antigenic schistosomal moieties is crucial. Accounting for pre-acquired immunity from natural exposure, in utero priming in addition to herd immunity, and induced by chemotherapy is crucial. Combining, as a multi-component approach, long-term effects of vaccination with short-term effects of chemotherapy as regular repeated vaccine-linked therapy seems most promising to achieve WHO’s endpoints of transmission elimination and morbidity control.
Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies
Authors: Suzuki Hiroyuki , Kannaka Kento , Uehara Tomoya
Published: April 2024

Radiolabeled antibodies are powerful tools for both imaging and therapy in the field of nuclear medicine. Radiolabeling methods that do not release radionuclides from parent antibodies are essential for radiolabeling antibodies, and practical radiolabeling protocols that provide high in vivo stability have been established for many radionuclides, with a few exceptions. However, several limitations remain, including undesirable side effects on the biodistribution profiles of antibodies. This review summarizes the numerous efforts made to tackle this problem and the recent advances, mainly in preclinical studies. These include pretargeting approaches, engineered antibody fragments and constructs, the secondary injection of clearing agents, and the insertion of metabolizable linkages. Finally, we discuss the potential of these approaches and their prospects for further clinical application.
Study of Optical Rogue Waves in Two-Dimensional Disordered Lattices
Authors: Song Jie , Li Meng , Li Fuqiang , Wang Ying , Chen Ziyang , Lou Cibo
Published: April 2024

We probed the impact of both the degree of disorder and nonlinearity on rogue waves (RWs) in two-dimensional disordered lattices. Our results unveiled that an increase in the disorder level under linear conditions heightened the probability of RW occurrence and simultaneously contracted the “long tail”. Interestingly, with the introduction of nonlinearity, this “long tail” became shorter compared with linear conditions. Nevertheless, in the context of disordered media, RW occurrence probability demonstrated relative stability—a distinct deviation from its conduct within homogeneous media.
Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs
Authors: Kovtareva Svetlana , Kusepova Lyazat , Tazhkenova Gaukhar , Mashan Togzhan , Bazarbaeva Karlygash , Kopishev Eldar
Published: April 2024

The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.
Novel Biocomposite of Starch and Flax Fiber Modified with Tannic Acid with Biocidal Properties
Authors: Stepczyńska Magdalena , Rytlewski Piotr , Moraczewski Krzysztof , Pawłowska Alona , Karasiewicz Tomasz
Published: April 2024

The purpose of this paper was to develop novel biocomposites with biocidal properties in microorganisms, with enhanced mechanical strength and hydrophobicity as well as with increased biodegradation rates. The main idea and the novelty of this work was to use cross-linking compounds and, at the same time, biocidal compounds—natural compounds of plant origin with biocidal properties. The authors assumed that the modification of flax fiber by natural plant compound will reduce the hydrophilicity of novel biocompositie. Biopolymer based on thermoplastic starch reinforced with flax fibres modified with tannic acid (TA) was prepared by extrusion and injection molding processes. The effects of TA modification on the mechanical and structural properties of biocomposites were analyzed through DMA, tensile tests, DSC, and TG. The biocidal and wettability properties of the biocomposites were investigated. The article also discusses the outcomes of research conducted on the structural characteristics and rates of the biodegradation of biocomposites.
Main Controlling Factors Affecting the Viscosity of Polymer Solution due to the Influence of Polymerized Cations in High-Salt Oilfield Wastewater
Authors: Hu Jiani , Fu Meilong , Li Minxuan , Luo Yuting , Ni Shuai , Hou Lijuan
Published: April 2024

In view of the high salinity characteristics of reinjection oilfield wastewater in the Gasi Block of Qinghai Oilfield, with the polymer produced by Shandong Baomo as the research target, we systematically investigated the variations in the impact of six ions, Na+, K+, Ca2+, Mg2+, Fe2+, and Fe3+, in the produced water from polymer flooding on the viscosity and stability of the polymer solution. Additionally, we provided the primary research methods for complexation in reinjected wastewater. Experimental results indicate that the main factors leading to a decrease in polymer viscosity are high-valence cations, with the descending order of their influence being Fe2+ > Fe3+ > Mg2+ > Ca2+ > Na+ > K+. High-valent cations also effect the viscosity stability of polymer solutions, and their order from greatest to least impact is: Fe2+ > Ca2+(Mg2+) > Fe3+ > Na+(K+). This article is focused on investigating the influencing factors and extent of the impact of oilfield wastewater on the viscosity of polymer solutions. It illustrates the response mechanism of cations to the viscosity of polymer solutions in reinjection wastewater polymerization. Through this research, the goal is to provide reference control indicators and limits for the water quality of injected polymers at oilfield sites. This ensures the stability and controllability of polymers in field applications and offers theoretical guidance for polymer flooding technology.
Chitosan-Based Grafted Cationic Magnetic Material to Remove Emulsified Oil from Wastewater: Performance and Mechanism
Authors: Du Sicong , Liu Chuang , Cheng Peng , Liang Wenyan
Published: April 2024

In order to remove high-concentration emulsified oil from wastewater, a chitosan-based magnetic flocculant, denoted as FS@CTS-P(AM-DMC), was employed in this present study. The effects of factors including the magnetic flocculant dose, pH values, and coexisting ions were investigated. A comparative dosing mode with the assistance of polyacrylamide (PAM) was also included. The evolution of floc size was studied using microscopic observation to investigate the properties of flocs under different pH values and dosing modes. Particle image velocimetry (PIV) and extended Deryaguin–Landau–Verwey–Overbeek models were utilized to illustrate the distribution and velocity magnitude of the particle flow fields and to delve into the mechanism of magnetic flocculation. The results showed that FS@CTS-P(AM-DMC) achieved values of 96.4 and 74.5% for both turbidity and COD removal for 3000 mg/L of simulated emulsified oil. In the presence of PAM, the turbidity and COD removal reached 95.7 and 71.6%. In addition, FS@CTS-P(AM-DMC) demonstrated remarkable recycling and reusability performances, maintaining effective removal after eight cycles. The strength and recovery factors of magnetic flocs without PAM reached 69.3 and 76.8%, respectively. However, with the addition of PAM, they decreased to 46.73 and 51.47%, respectively. During the magnetophoretic processes, FS@CTS-P(AM-DMC) and oil droplets continuously collided and aggregated, forming three-dimensional network aggregates. Moreover, the magnetic floc generated a swirling motion, and the residual emulsified oil droplets could be further captured. Emulsified oil droplets were primarily removed through charge neutralization under acidic conditions. Under neutral and alkaline conditions, magnetic interactions played a major role in magnetic flocculation.
Automatic Detection of Banana Maturity—Application of Image Recognition in Agricultural Production
Authors: Yang Liu , Cui Bo , Wu Junfeng , Xiao Xuan , Luo Yang , Peng Qianmai , Zhang Yonglin
Published: April 2024

With the development of machine vision technology, deep learning and image recognition technology has become a research focus for agricultural product non-destructive inspection. During the ripening process, banana appearance and nutrients clearly change, causing damage and unjustified economic loss. A high-efficiency banana ripeness recognition model was proposed based on a convolutional neural network and transfer learning. Banana photos at different ripening stages were collected as a dataset, and data augmentation was applied. Then, weights and parameters of four models trained on the original ImageNet dataset were loaded and fine-tuned to fit our banana dataset. To investigate the learning rate’s effect on model performance, fixed and updating learning rate strategies are analyzed. In addition, four CNN models, ResNet 34, ResNet 101, VGG 16, and VGG 19, are trained based on transfer learning. Results show that a slower learning rate causes the model to converge slowly, and the training loss function oscillates drastically. With different learning rate updating strategies, MultiStepLR performs the best and achieves a better accuracy of 98.8%. Among the four models, ResNet 101 performs the best with the highest accuracy of 99.2%. This research provides a direct effective model and reference for intelligent fruit classification.
Exploring the Effects of Topography on Leaf Area Index Retrieved from Remote Sensing Data at Various Spatial Scales over Rugged Terrains
Authors: Zheng Yajie , Xiao Zhiqiang , Shi Hanyu , Song Jinling
Published: April 2024

Topography significantly affects remotely sensed reflectance data and subsequently impacts the retrieval of the leaf area index (LAI) from surface reflectance data over rugged terrains. However, most LAI inversion algorithms ignore the influence of terrain. This paper quantitatively analyzes the topographic effects on LAI values retrieved from remote sensing data at various spatial scales (30, 90, 270, 540, 1080, and 5400 m) over rugged terrains. The PRO4SAILT (PROSPECT + 4SAILT) model and the Proy algorithm were used to simulate multiscale surface reflectance for different LAI values over rugged terrains. Based on Gaussian process regression (GPR), an LAI inversion algorithm that ignores terrain effects was first developed. The simulated multiscale reflectance data were subsequently input into the inversion algorithm to retrieve LAI values. Finally, the retrieved LAI values were compared with the corresponding reference LAI values. The results demonstrate that the finer the spatial resolution is, the more significant the topographic effects on the retrieved LAI values are. When the reference LAI is five, as the spatial resolution increases from 5400 m to 30 m, the mean percentage error (MPE) of the retrieved LAI increases from 10.46% to 13.72%, and the root mean square error (RMSE) increases from 0.5376 to 1.005. Regardless of the spatial resolution, the error in the retrieved LAI values increases with an increasing terrain slope. When the reference LAI is five and the spatial resolution is 30 m, the MPE at a slope of 15°–30° is close to 5%, and the RMSE is close to 0.3. The MPE at a slope of 30°–45° is close to 20%, and the RMSE is close to one. In addition, the accuracy of the retrieved LAI values is closely related to the sky view factor (SVF). In general, the larger the SVF is, the smaller the error in the retrieved LAI values. In addition, the conversion relationships between the retrieved LAI values using the algorithm that ignores terrain effects and the true LAI values are provided in this study.
Green Practices in Action: Examining HRM’s Role in Fostering Environmental Performance in Egypt’s Hospitality Sector
Authors: Abedelrahim Selma , Qassim Amal Abdulmajeed , Alatawi Fatmah Mohmmed H.
Published: April 2024

This study examines the dynamic relationship between green human resource management (green HRM), environmental performance (EP), green employee behavior (GEB), and environmental knowledge and awareness (EKAW) within the Egyptian hospitality sector context. Using Pearson correlation coefficients and regression analyses on a sample of 400 staff members from hotels and tourist villages in Egypt, the study examines green HRM practices’ influence on EP, mediated by GEB and EKAW. The findings reveal significant positive correlations between green HRM practices and these mediators, indicating that comprehensive environmental strategies and incentive management are pivotal in promoting eco-friendly practices among employees. The study further confirms GEB and EKAW’s substantial mediating roles in enhancing EP. The results also suggest that while EKAW and GEB independently contribute to EP, their interaction, and the role of environmental awareness as a potential mediator warrant further examination. This research contributes to the literature on sustainable business practices by underscoring human resource strategies’ integral role in achieving environmental sustainability goals, highlighting the importance of incentivizing green practices, and cultivating an organizational culture prioritizing EKAW. These insights are precious for organizations seeking to enhance their ecological footprint through effective green HRM practices.
Optimal Vehicle Scheduling and Charging Infrastructure Planning for Autonomous Modular Transit System
Authors: Chang Ande , Cong Yuan , Wang Chunguang , Bie Yiming
Published: April 2024

Prioritizing the development of public transport is an effective way to improve the sustainability of the transport system. In recent years, bus passenger flow has been declining in many cities. How to reform the operating mode of the public transportation system is an important issue that needs to be solved. An autonomous modular bus (AMB) is capable of physical coupling and uncoupling to flexibly adjust vehicle capacity as well as provide high-quality service under unbalanced passenger demand conditions. To promote AMB adoption and reduce the operating cost of the bus route, this paper presents a joint optimization method to simultaneously determine the AMB dispatching plan, charging plan, and charging infrastructure configuration scheme. Then, a mixed-integer programming model is formulated to minimize the operating costs of the bus route. A hybrid intelligent algorithm combining enumeration, cloning algorithm, and particle swarm optimization algorithm is designed to resolve the formulated model. Subsequently, an actual bus route is taken as an example to validate the proposed method. Results indicate that the developed method in this paper can reduce the operating costs and operational energy consumption of the route compared with the real route operating plan. Specifically, the reduction ratio of the former is 23.85%, and the reduction ratio of the latter is 5.92%. The results of this study validate the feasibility and advantages of autonomous modular transit service, contributing positively to the sustainable development of the urban public transportation system.