bluuebunny/crossref_metadata_2025 huggingface dataset:
Ketahanan Mortar Ringan Campuran Gula Aren dan Ragi pada Suhu Tinggi: Narrative Review
Authors:   Universitas Riau, Christina Shelly , Kristanto Daniel ,   Universitas Riau, Hafisuddin Fahri ,   Universitas Riau, Olivia Monita ,   Universitas Riau
Published: November 2022

Lightweight mortar is a specific type of mortar that is made by adding a foaming agent. A lightweight mortar has a lot of pores or cavities filled with air, which reduces the mortar’s weight. The lightweight mortar has better heat insulation than an ordinary mortar with its high porosity. There has been much research and application of lightweight mortar in the last few years. This review focuses on lightweight mortar made with a natural additive that has good high-temperature resistance. Many additives can be used, such as yeast and palm sugar. Yeast is a microorganism that can be used as a foaming agent because it can produce carbon dioxide (CO2) that creates a lot of pores in the mortar through the glycolysis process. Palm sugar is a disaccharide groups sugar, and sucrose, consisting of glucose and fructose. Glucose can reduce gypsum consumption in mortar and ettringite formation. Besides, sugar contains lignin, which can increase the bonding strength of mortar components. This study proves that the innovation of lightweight mortar with organic additives has a long-term potency with its durability at high temperatures.
Evaluation of Flexible Pavement Damage Using The PCI (Pavement Condition Index) Method Based on Core Drill Data, Case Study: on The Mandarin Road to The President Nicolao Lobato Roundabout and The Bebonuk Road in Dili City, Timor-Leste
Authors:   Universitas Jember, de Almeida Brigida Freitas , Krisnamurti Krisnamurti ,   Universitas Jember, Ratnaningsih Anik ,   Universitas Jember, Hasanuddin Akhmad ,   Universitas Jember
Published: November 2022

Localization and characterization of road damage are used in an effort to accelerate road repairs. The evaluation results were compared with field data and laboratory data. The results of the analysis show that the average PCI on the right side of the road reaches a value of 68 with a good rating good, on the left side it is worth 62 with a good rating good, and for the Bebonuk road section it is worth 39 with a bad rating poor. The average value of core drill is 86.85% and 99.92%, while the average PCI value is 35.36%. Asphalt content extracted with specifications 0.3, JMF 5.4% and penetration of 5.1%.
Analisis Prioritas Penanganan Banjir Kali Konto, Provinsi Jawa Timur
Authors:   Universitas Jenderal Achmad Yani, Indrawati Dian , Adityawan Mohammad Bagus ,   Institut Teknologi Bandung, Ichsan Diki Maulana ,   Institut Teknologi Bandung, Harlan Dhemi ,   Institut Teknologi Bandung, Nugroho Joko ,   Institut Teknologi Bandung
Published: November 2022

Flood in Kali Konto is a disastrous hazard which strikes a lot of housing, infrastructures and paddy fields along its river banks almost every year. In 2021, along with destroyed revertment at roolagh 70 area, flood inundated more than 10 villages in Kabupaten Jombang and several more in Malang and Kediri. However, flood management at Kali Konto needs special consideration because several conditions, include watershed area pattern, extremely slope condition changing, numerous materials from Kelud mountain eruption in several part of Konto river, and a lot of infrastructures which laid in Konto river. This paper discussed about appropriate infrastructures which derived from hydrology and hydraulics modeling for Q2 and Q50 flood return periods. Since the model resulted 49 locations, Analytical Hierarchy Process (AHP) model used for determining priority for scaling down flood hazard in Kali Konto. The most priority comes to Karang Tengah, Blaru and Bugasur Kedaleman area based on the most losses occurred.
Estimasi Dimensi Optimum dan Rasio Tulangan Gedung Hotel Yogyakarta dengan Artificial Neural Network
Authors:   Universitas Gadjah  Mada, Harahap Kinanti Faradiba , Aminullah Akhmad ,   Universitas Gadjah  Mada, Priyosulistyo Henricus ,   Universitas Gadjah  Mada
Published: November 2022

Cost estimation at the conceptual design stage of a building is necessary because it is considered as a fundamental input in further decision making. This paper presented a neural network method in approximating the optimum dimension and the minimum reinforcement ratio of beams and columns at the conceptual design stage of hotel buildings in Yogyakarta. A group of 27 building variations were prepared as the training data for the set up neural network model. Fourteen empirical formulas were obtained which could be used to estimate the optimum dimension and minimum reinforcement ratio of beams and columns with 5 parameters which consist of soil sites class, beam spans, number of floors, concrete strengths and diameters of the reinforcing bar.
Evaluation of Penataran Train Fares During The Covid-19 Pandemic Using ATP-WTP Methods
Authors:   Universitas Brawijaya, Firmansyah Nur Aldi , Wicaksono Achmad ,   Universitas Brawijaya, Anwar Muhammad Ruslin ,   Universitas Brawijaya
Published: November 2022

Indonesian Railways Company must increase the fare for the Penataran Train due to additional operational costs in providing the COVID-19 health protocol. On the other hand, people experience a reduction in monthly income due to the lack of activities outside the home. Ticket prices must be adjusted to determine the number of subsidies borne by the government. This study aims to evaluate the fare of the Penataran Train using the Ability To Pay (ATP) and Willingness To Pay (WTP) methods. Questionnaires have been distributed to 417 respondents using the Google Form application. The results showed that the ATP was higher than the WTP 1 without passenger expectations, and the ATP was lower than the WTP 2 with passenger expectations. Restriction of seating capacity is the most expected service by respondents. The recommended fare is IDR 33,478.00/trip, and the public service obligation is IDR 54,816.00/trip.
Selection of Floor Covering Materials Using Life Cycle Cost Analysis on The Apartment Development Project South Tangerang
Authors:   Universitas Brawijaya, Ramadhan Muhammad Mahesa , Wijatmiko Indradi ,   Universitas Brawijaya, Devia Yatnanta Padma ,   Universitas Brawijaya
Published: November 2022

Developing an area can be started with infrastructure development. One example of such infrastructure is an apartment with a function as a means of residence and economic development in the area around the apartment. The South Tangerang X Apartment development project is one of the objects studied in this research. This study aims to select alternative materials for floor work based on the building cycle using life cycle cost (LCC) analysis with such a large project value. The research method used is Pareto diagram analysis to select the work to be analyzed. The LCC analysis uses a present worth analysis method with a gate-to-gate phase. This study indicates that the LCC analysis on Apartment Project X South Tangerang found the results on alternative KR1B HT floor work, namely alternative 2 of IDR. 1,437,912,015 on the KR1A HT flooring; the chosen alternative is alternative 2 of IDR. 989,177,787 on the chosen alternative KR4 HT floor work, namely alternative 2 of IDR. 1,510,914,248, and for the KR5A marble floor, the chosen alternative is alternative 2 of IDR. 617,202,771. The result of the LCC generated savings of IDR. 2,364,054,553.
Hernia interna por divertículo de Meckel: Una causa rara de obstrucción intestinal
Authors: Sandoval López Jesús Carlos , Beyuma-Mora Hugo E , Labastida-Ramírez Diana L
Published: November 2022

Meckel's diverticulum is the remnant of the omphalomesenteric duct and is considered the most common congenital hernia secondary to a Meckel's diverticulum, a rare cause of bowel obstruction. Keywords: Meckel’s diverticulum; intestinal obstruction; omphalomesenteric duct; congenital gastro-intestinal malformation.
DATOS ABIERTOS EN VENEZUELA
Authors: Sandoval Sucre Franklin
Published: November 2022

Los datos abiertos se han convertido en los últimos años en un tema de creciente interés. Los gobiernos están implementando de forma creciente iniciativas que buscan ampliar el acceso a datos relacionados al funcionamiento de sus instituciones. Aunque en la República Bolivariana de Venezuela se han llevado adelante diferentes iniciativas relacionadas con el gobierno abierto, todavía no se ha realizado una evaluación empírica sobre la relación entre este último y la implementación efectiva de mecanismos de acceso a los datos abiertos. Este artículo evalúa, de forma exploratoria, el estado de los datos abiertos en la administración pública nacional venezolana. Para ello, se utiliza la información proporcionada por estudios internacionales, así como el análisis del contenido y funcionalidades de los portales de datos abiertos. Se concluye que a la administración pública venezolana todavía le queda mucho por avanzar en materia de datos abiertos, tanto en la adopción de este tipo de iniciativa, como en el desarrollo de su sitio web ya existente, especialmente la utilización de datos por parte de la ciudadanía.
Elastisitas penerimaan pajak dan pendapatan asli daerah Kota Jambi
Authors: Maulana M Reno , Rahmadi Selamet , Parmadi Parmadi
Published: November 2022

The purpose of this study is 1) to analyze the proportion of sources of local tax revenues to total local tax revenues and locally-generated revenue in the city of Jambi. 2) To analyze the elasticity of sources of local tax revenue and the elasticity of locally-generated revenue in Jambi City. The data used are secondary data during the period 2006-2015. Data were analyzed descriptively quantitative. The results of the study found that 1) The proportion of the largest tax source to total taxes and locally-generated revenue in Jambi City in 2006-2015 came from street lighting tax, while the lowest proportion of entertainment tax; 2) The largest tax elasticity in Jambi City in 2006-2015 is entertainment tax and the lowest is advertisement tax Keywords: Sources of tax revenue, Regional taxes, Locally-generated revenue

 Abstrak Tujuan Penelitian ini adalah 1) untuk Menganalisis proporsi sumber-sumber penerimaan pajak daerah terhadap total penerimaan pajak daerah dan Pendapatan Asli Daerah di Kota Jambi. 2) Untuk menganalisis timgkat elastisitas sumber-sumber penerimaan pajak daerah dan elastisitas Pendapatan Asli Daerah di Kota Jambi. Data yang digunakan adalah data sekunder selama periode 2006-2015. Data dianalisis secara deskriptif kuantitatif. Hasil penelitian menemukan bahwa 1) Proporsi sumber pajak terbesar terhadap total pajak dan Pendapatan Asli Daerah di Kota Jambi pada Tahun 2006 -2015  bersumber dari pajak penerangan jalan, sedangkan proporsi terendah dari pajak hiburan; 2) Elastisitas pajak terbesar di Kota Jambi pada Tahun 2006 -2015  adalah pajak hiburan dan yang terendah adalah pajak reklame Kata Kunci : Sumber-sumber Pajak daerah, Pajak Daerah, Pendapatan Asli Daerah.
Rim do Desportista
Authors:   Dr. Ricardo Miranda  Hospital Prof. Dr. Fernando da Fonseca, Miranda Ricardo ,   Unidade de Medicina do Exercício do Centro de Medicina Naval, Henriques Moisés ,   Unidade de Reabilitação e Departamento de Saúde Ocupacional do Centro de Medicina Naval
Published: November 2022

Today’s sports medicine physicians will commonly encounter athletes with renal injury. Haematuria is one of the first signs. The types of renal injury include renal trauma and exercise-induced haematuria. The single kidney athlete also poses a great challenge to the physicians. Many studies have described the prevalence of haematuria in both athletes and nonathletes. In the athletic population, the incidence is usually considerably higher. Using a gradual return to play progression and close monitoring, will enhance the probability of returning without complications.
Reportagem sobre o 6th International Consensus Conference on Concussion in Sport
Authors:   Soc Portuguesa de Medicina Desportiva, Tomás Rita
Published: November 2022

A 6th International Consensus Conference on Concussion in Sport decorreu entre 27 e 28 de outubro, no Postillion Hotel & Convention Centre Amsterdam. Depois de ter sido adiado dois anos e ter mudado de cidade (em 2020 e 2021 estava previsto ser em Paris), finalmente peritos de todo o Mundo reuniram-se para atualizar o Concussion in Sport Group Consensus Statement. A documento anterior, o Consenso de Berlim, foi publicado em 2017 na sequência da quinta reunião que decorreu em outubro de 2016 em Berlim. ....
Analisis Bimbingan Rohani Islam dalam Menumbuhkan Karakter Anak di Masa Depan
Authors: Nikmah Laelatul , Amalia Nurani Firda , Azizah Nur
Published: November 2022

Riwayat artikel: Diterima 12 Juni 201x Direvisi 20 Agustus 201x Diterima 26 Agustus 201x Bimbingan agama Islam penting bagi anak sejak dini. pemberian bimbingan rohani Islam dapat dilakukan melalui Taman Pendidikan Al-Qur'an (TPQ). Karena pada kenyataannya anak yang kurang mendapat bimbingan rohani memiliki perilaku yang tidak baik, seperti berbohong, berdebat, keras kepala, dan masih banyak perilaku buruk lainnya yang dimiliki anak saat ini. Penelitian ini bertujuan untuk mengetahui bimbingan spiritual Islami yang diberikan siswa usia sekolah dasar di TPQ Al-Hidayah Cilongok agar mampu menumbuhkan akhlak yang baik di masa yang akan datang. Data diperoleh melalui observasi dan wawancara dengan Ustadz atau Ustadzah di TPQ Al-Hidayah.Hasil penelitian adalah: anak usia sekolah dasar di TPQ Al-Hidayah diberikan bimbingan spiritual islam melalui membaca Iqra atau Juz 'Amma, mengaji, mengaji kitab kuning. , tahlil, dan istighfar, menghafal surat-surat pendek yang nantinya akan disetorkan kepada Ustadz atau Ustadz di TPQ Al-Hidayah. Selain itu materi tentang akhlak atau akhlak Islami juga diberikan agar kelak kelak anak-anak usia sekolah dasar mampu menerapkannya dalam kehidupan.
"The iconographic invention. Regional identities and Nation in the Mexican cinema of the Golden Age"
Authors:   ", Castro Ricalde María de la Cruz de Fátima ,   UNIVERSIDAD AUTÓNOMA METROPOLITANA UNIDAD CUAJIMALPA"
Published: November 2022

This book aims to identify how the region is configured, in relation to the predominant approaches to the nation emanating from the center of the country, during the golden age of Mexican cinema. It is assumed that although the idea has circulated there was a hegemonic thought about the nation in the post-revolutionary period, rather, it derived from the policies of state institutions and intellectuals such as Manuel Gamio and José Vasconcelos. It discusses how, when predominant versions of the national project encounter some cultural manifestations and the thinking of intellectual representatives of the regions, they experience fractures and modifications. Two decisive stages for the consolidation of national identity have been extensively studied. The first was in the nineteenth century, during the decades after Mexican independence in 1810. The second, in the post-revolutionary period, was within the framework of the national project. In this period, a narrative was required to speak of a nation proud of its indigenous past, cohesive in the present, and with an eye on a prosperous and modern future.
Laboratory Findings of Aluminium Refinery Residue (ARR) Stabilized with GGBS and Alkali Solution
Authors:   Research Scholar, Department of Civil Engineering, NITK, Surathkal, Mangaluru, Karnataka, India, Kudachimath Nityanand S
Published: November 2022

Aluminium Refinery Residue (ARR) is the residual product generated during the manufacturing process of Alumina. The Bayer process is most commonly adopted to extract alumina from the ore bauxite. Globally, nearly 3 billion tons of Aluminium Refinery Residue (ARR) is stored. The storage of untreated Aluminium refinery residue consumes more open land for storage. The present article discusses the material properties like grain size analysis, consistency limits, specific gravity, maximum dry density, optimum moisture content, unconfined compression strength test, and durability properties of stabilized Aluminium refineries residue with ground granulated blast furnace slag (25%), a combination of alkaline solution at 5% Na2O, Silica modulus and its probable application as road construction material. Results have shown an increase in UCS (average 381%) values of the stabilized ARR at 0,7 and 28 days of curing compared with same day cured sample and Problems associated with the earthen road construction material is the reduced strength and weathering due to exposure to harmful climatic conditions. So the prominence has been given to the durability of the stabilized Aluminium Refinery Residue (ARR) by considering the effect of Wetting and Drying (W and D) cycles on its weight loss which is within the limits as specified by codes.
Cefuroxime-induced Anaphylaxis: A Case Report
Authors:   MD Internal Medicine & Associate Professor, Department of General Medicine BKL Walawalkar Rural Medical College and Hospital, Dervan, Ratnagiri, Maharashtra, India, Ratnaparkhe Vikas
Published: November 2022

Cefuroxime auxetil is a second-generation cephalosporin antibiotic that can cause immediate hypersensitivity reactions, ranging from mild urticaria to severe anaphylactic shock. Anaphylactic reactions typically involve multiple systems, notably the skin, the respiratory and cardiovascular systems. Here, we report an unusual case presented with anaphylaxis secondary to IV cefuroxime administration with no history of any allergic reaction to date. There was no family history of allergic reactions. A 54 years old male was diagnosed witha left knee meniscal injury and so was posted for arthroscopy. He was given IV cefuroxime (ZOCEF) 1.5 gm intravenously preoperatively and the patient collapsed immediately. The patient developed chills with rigor, change in voice, profuse sweating, itching and rash all over the body, severe chest pain, difficulty in breathing, abdominal pain, vomiting, and drowsiness. The patient had hypotension with cold peripheral extremities. He was severely drowsy, and arousable only after deep stimuli. The patient was resuscitated successfully with IV fluids and steroids. This case shows that clinicians must be cautious while giving a drug in any form to apatient in OPD or IPD.
90-letni Zygmunt Bauman: Schopferkraft i jego dwoistości
Authors: Blackshaw Tony
Published: November 2022

W listopadzie 2015 roku Zygmunt Bauman obchodził 90. urodziny, będąc przy tym jak zwykle żywotnym, produktywnym i inteligentnym. Po ponad 70 opublikowanych książkach, z których każda analizuje jeden temat i otwiera drzwi na wszystkie strony, jego praca pozostaje istotnym punktem odniesienia w socjologii. Bauman nadal jest jednym z najbardziej elektryzujących socjologów, jednym z najbłyskotliwszych i najbardziej elastycznych myślicieli w swym pokoleniu. Wyjaśnia to, dlaczego niektórzy komentatorzy uznali go za jednego z najważniejszych żyjących socjologów. Gwoli ścisłości, jego prace poddane zostały również zdecydowanej krytyce. Po zarysowaniu rozumowania umniejszających jego dokonania w niniejszym artykule rozwija się myśl, że więcej ona mówi o stanie obecnej kultury w socjologii niż jakości pracy Baumana. Sposób praktykowania swego rzemiosła przez Baumana można uznać za osobliwy, nie jest on jednak w socjologii niczym nowym. Inni ważni socjologowie – Marks, Simmel, Weber – byli również nonkonformistami, lecz we współczesnym świecie Bauman jest wyjątkiem. Bauman, jak i inni ważni nonkonformiści, jest wytworem własnej niezwykłej biografii. Podobnie jak niektórzy z nich potrafił on wykorzystać podwójną wizję emigranta, która wyostrzyła jego osobistąświadomość wieloznaczności nowoczesności. W tekście ukazuje się, że socjologia w rękach Baumana tworzy odmienną mapę kognitywną tego, co zwykli ludzi uznają za rzeczywistość, zaś my wszyscy bierzemy za oczywistość. Punktem wyjścia jego pracy jest hermeneutyczne zrozumienie przygodności i wieloznaczności strumienia życia. Baumanowskie metafory opisujące tę nowoczesność są mesjanistyczne i ekologiczne: ratują pewną odmianę socjologii, która jest zagrożonym gatunkiem. Ostatnia część artykułu rzuca wyzwanie tendencji krytyków Baumana, wedle których ostateczną ochroną socjologii jako dyscypliny akademickiej leży poza władzą społeczną, znajdując się we władzy tego, co obiektywne. Bauman zajmuje odmienne stanowisko, jego socjologia bowiem rozpościera się między dwiema „rzeczywistościami” – hermeneutyczną socjologią i socjologiczną hermeneutyką. Wskutek nieustannego procesu wymiany między nimi, potrafi on „odkryć to, co istnieje”. Oto poczucie wolności, które promieniuje z dialektyki, która cechuje jego dzieło.
DMFF: An Open-Source Automatic Differentiable Platform for Molecular Force Field Development and Molecular Dynamics Simulation
Authors: Wang Xinyan , Li Jichen , Yang Lan , Chen Feiyang , Wang Yingze , Chang Junhan , Chen Junmin , Zhang Linfeng , Yu Kuang
Published: November 2022

In the simulation of molecular systems, the underlying force field (FF) model plays an extremely important role, determining the reliability of the simulation. However, the quality of the state-of-the-art molecular force fields is still unsatisfactory in many cases, and the FF parameterization process largely relies on human experience, which is not scalable. To address this issue, we introduce DMFF, an open-source molecular FF development platform based on automatic differentiation technique. DMFF serves as a powerful tool for both top-down and bottom-up FF development. Using DMFF, both energies/forces and thermodynamic quantities such as ensemble averages and free energies can be evaluated in a differentiable way, realizing an automatic, yet highly flexible force field optimization workflow. DMFF also eases the evaluation of forces and virial tensors for complicated advance force fields, helping the fast validation of new models in molecular dynamics simulation. DMFF has been released as an opensource package under the LGPL-3.0 license and is available at https://github.com/deepmodeling/DMFF.
Bond dissociation energies of X−H bonds in proteins
Authors: Treyde Wojtek , Riedmiller Kai , Gräter Frauke
Published: November 2022

Knowledge of reliable X−H bond dissociation energies (X = C, N, O, S) for amino acids in proteins is key for studying the radical chemistry of proteins. X−H bond dissociation energies of model dipeptides were computed using the isodesmic reaction method at the BMK/6-31+G(2df,p) and G4(MP2)-6X levels of theory. The density functional theory values agree well with the composite- level calculations. By this high level of theory, combined with a careful choice of reference compounds and peptide model systems, our work provides a highly valuable data set of bond dissociation energies with unprecedented accuracy and comprehensiveness. It will likely prove useful to predict protein biochemistry involving radicals, e.g., by machine learning.
Use of forests for recreational activities (practical exercise lessons)
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Lebedev A. V.
Published: November 2022

The textbook reveals the features of designing forest landscapes for recreational purposes on forest lands. Issues on landscape and inventory work on the design and improvement of forests, on the implementation of forestry activities (forest care, forest sanitation, fire protection and forest regeneration) considers. The textbook is intended for full-time and part-time undergraduate students studying in the following areas: 35.03.01 - Forestry and 35.03.10 - Landscape architecture.
Bir Gizli Katmanlı Yapay Sinir Ağlarında Optimal Nöron Sayısının İncelenmesi
Authors: ÜNAL Tayfun , ÇİFTÇİ Ünver , URGAN Nurkut Nuray
Published: November 2022

Bu makalede, bir gizli katmanlı yapay sinir ağları için optimal nöron sayısı araştırılmıştır. Bunun için teorik ve istatiksel çalışmalar yapılmıştır. Optimal nöron sayısını bulmak için global minimum bulmak gereklidir. Ancak yapay sinir ağlarının eğitimi konveks olmayan bir problem olduğundan optimizasyon algoritmaları ile global minimum bulmak zordur. Bu çalışmada global minimumu dolayısıyla optimum nöron sayısını bulmak için baskı maliyet fonksiyonu önerilmiştir. Baskı maliyet fonksiyonu yardımıyla global minimumu veren yapay sinir ağı modelinin nöron sayısının, optimal nöron sayısını verdiği gösterilmiştir. Ayrıca baskı maliyet fonksiyonu XOR veri kümesi ve daire veri kümesi üzerinde test edilmiş ve XOR veri kümesi üzerinde %99, daire veri kümesi üzerinde ise %97 başarı elde edilmiştir. Bu veri kümeleri için optimal nöron sayısı tespit edilmiştir.
Short communication: Irrigation Efficiency Improvement Reserve in Central Asia Compared to Israel
Authors:   Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, st. Kari Niyazova, 39, Tashkent, 100000, Uzbekistan, Khaydarov Aziz , Petrov G. ,   Center for Innovative Development of Science and New Technologies of the National Academy of Sciences of the Republic of Tajikistan, 33 Rudaki Ave., Dushanbe, 734025, Tajikistan, Mitusov A.
Published: November 2022

The paper aims to assess the reserves of water conservation in irrigated agriculture in Central Asia (CA) compared with Israel. We compared specific water consumption, precipitation, and evapotranspiration indicators during the growing season. The article shows that taking into account the above parameters, the actual difference in water consumption between Israel and the countries of Central Asia is only 21.4% of the real irrigation rate. It is the limiting value; in reality, the reserves are even less since evapotranspiration from the main irrigated areas is slightly higher than the average in Central Asia. In addition, large volumes of water are spent on leaching saline lands in Central Asia
COVID-19–Related Functional Impairment in a Community Sample of Korean Adults: Associations With Depression, COVID-19 Infection Fear, and Resilience
Authors: Park Yun-ju , Jung Young-Eun , Kim Moon-Doo , Bahk Won-Myong
Published: November 2022

Objective We aimed to determine the effects of depression, COVID-19 infection fear, and resilience on COVID-19–related functional impairment.Methods We obtained data from 476 community-dwelling adults aged 20–69 years living in Jeju, South Korea, and evaluated the relationships between COVID-19–related functional impairment (work/school, social, and home life) and sociodemographic and healthrelated characteristics, COVID-19–related life changes (financial difficulties since the pandemic, employment change, interpersonal conflict), and clinical characteristics, including depression, COVID-19 infection fear, and resilience.Results Functional impairment in the home life domain was associated with marital status and monthly income. Greater work/school, social, and home life functional impairment was significantly associated with all COVID-19–related life changes. Regression analysis indicated that resilience modulated the positive associations of COVID-19–related functional impairment with symptoms of depression and COVID-19 infection fear when relevant factors were controlled for.Conclusion Our results suggest the importance of clinical characteristics, including depression, COVID-19 infection fear, and resilience for understanding functional impairment related to COVID-19. These results have important implications for interventions aimed at reducing depression and COVID-19 infection fear, and enhancing resilience.
The Impact of the COVID-19 Pandemic and Social Distancing on Cognition of Alzheimer’s Disease Patients
Authors: Joo Soo Hyun , Hahn Chang Tae , Lee Chang Uk
Published: November 2022

Objective The risk of rapid cognitive decline in Alzheimer’s disease (AD) during the coronavirus disease 2019 (COVID-19) pandemic has been recognized. The purpose of this study was to investigate the cognitive decline in such patients during the COVID-19 pandemic by evaluating changes in their cognitive measure parameters before and after the pandemic.Methods This was a retrospective cohort study conducted in AD patients during their first visit and one-year regular follow-up for testing cognitive function at the Geriatric Psychiatry Clinic of Seoul St. Mary’s Hospital. Changes in the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Sum of Box for CDR (CDR-SB) scores were investigated. A time series analysis was performed to determine whether there was a significant difference in the MMSE, CDR, and CDR-SB scores of AD patients in pre- and post–COVID-19 periods.Results Overall, 130 AD patients aged 60 to 93 years were assessed. Their baseline mean MMSE score was 22.30 which had decreased to 21.08 at the one-year follow-up. Before November 2019, the average CDR differences for one year was 0.06, but after November 2019, it increased to 0.36 (p<0.001). Before November 2019, the average of the CDR-SB change value for one year was 1.69, but after November 2019, it increased to 3.00 (p<0.001). The difference in MMSE values for one year was not statistically significant. The time series analysis revealed a significant increase in the CDR and CDR-SB scores by approximately 0.47 (p=0.005) and 2.39 (p=0.002), before and after November 1, 2019, respectively.Conclusion This study revealed that the COVID-19 pandemic and social distancing worsen cognitive function in AD patients rapidly. Exposure to the COVID-19 pandemic and social distancing for at least seven months worsen cognitive decline significantly. Therefore, in order to minimize the adverse effects of the cognitive decline in these patients, the period of social distancing should be minimized.
Confounding by Indication in Studies of Selective Serotonin Reuptake Inhibitors
Authors: Lee Jimin , Chang Sung Man
Published: November 2022

Selective serotonin reuptake inhibitors (SSRIs) are used worldwide as the first-line pharmacological treatment for depression. Although SSRI use can increase the risk of suicide, fractures, and infertility, the nature of these relationships is controversial. This review reports confounding by indication and confounding by severity for SSRI side effects in previously published observational studies. The PubMed and Google Scholar databases were searched for English-language articles published from 2005 to 2022. SSRIs are often prescribed for depressive symptoms, and depression is associated with an increased risk of side effects. Therefore, confounding by indication, whereby patients are selected for a particular treatment depending on their diagnosis or severity of illness, may lead to erroneous treatment conclusions, resulting in an adverse outcome. The side effects of SSRIs that can be considered due to confounding by indication or severity include suicide, fractures, infertility, atrial fibrillation, stroke, autism spectrum disorder, and congenital malformation. When prescribing SSRIs for depression, physicians must consider confounding by indication and severity in the management of side effects. In addition, medication discontinuation should be carefully considered when side effects occur during the treatment.
Coronelismo eletrônico não é uma metáfora
Authors: Aires Janaine , Dos Santos Suzy
Published: November 2022

O coronelismo eletrônico designa um tipo de sistema alicerçado em compromissos recíprocos e de mútua dependência entre a mídia e a política. Este artigo discute imprecisões e divergências conceituais a partir de duas questões centrais: “O coronelismo eletrônico é uma questão regional?” e “Qual a principal mercadoria do sistema de coronelismo eletrônico?”. Elabora-se, ainda, uma categorização dos atores que articulam esse sistema, que se subdividem em: proprietários de sistemas midiáticos; famílias governamentais; lideranças personalistas; e comunicadores-políticos. Por fim, como resultado, o artigo apresenta um quadro comparativo entre os seus diferentes tipos de capital político.
Explaining polarized trust in scientists: A political stereotype-approach
Authors: Altenmüller Marlene Sophie , Wingen Tobias , Schulte Anna
Published: November 2022

Public trust in science is polarized along political lines. Conservatives trust scientists and their findings less than do liberals – but why? Here, we show that people across the political spectrum hold stereotypes about scientists' political orientation (e.g., "scientists are liberal"), compare that to their own political orientation, and only trust scientists to the degree that they perceive them to be ideologically similar. Thus, we predict that the link between political orientation and trust in scientists is affected by political stereotypes about scientists. We tested this hypothesis in five studies in Germany and the US and combined a series of highly controlled experimental and correlational studies (total N = 2,859) with a large-scale analysis of Twitter data (N = 3,977,868). We experimentally manipulated scientists' perceived political orientation (study 1) or used naturally occurring variations in political stereotypes about scientific disciplines (e.g., "sociologists are liberal", studies 2 to 5). Across all studies, we consistently observed that stereotypes about scientists explain the link between political orientation and trust in scientists. Results showed that conservatives’ distrust in scientists is substantially reduced for stereotypically moderate disciplines (e.g., economists) and even reversed for scientists perceived as conservative. Confirming the critical consequences of this finding, the effect shaped participants' perceptions of the value of science, their protective behavior intentions during a pandemic, policy support, and information-seeking behavior.
Childhood Personality and Academic Performance: A Sibling Fixed-Effects Study
Authors: Constantinou Andrea , von Soest Tilmann , Zachrisson Henrik Daae , Cheesman Rosa , Ystrom Eivind
Published: November 2022

This study investigates associations between personality traits at age eight and academic performance between ages 10 to 14, controlling for family confounds. Sibling data from the Norwegian Mother and Child Cohort Study (MoBa) were used (n = 9,701). First, we estimated overall associations between Big Five personality traits and academic performance, including literacy, numeracy, and foreign language. Second, we added sibling fixed effects to remove unmeasured confounders shared by siblings as well as rating bias. Openness to Experience (between-person β=0.22 [95% CI 0.21 - 0.24]) and Conscientiousness (between-person β=0.18 [95% CI 0.16 - 0.20]) were most strongly related to educational performance. Agreeableness (between-person β=0.06 [95% CI -0.08 - 0.04]) and Extraversion (between-person β=0.02 [95% CI 0.00 - 0.04]) showed small associations with educational performance. Neuroticism had a moderate negative association (between-person beta=-0.14 [95% CI -0.15 - 0.11]). All associations between personality and performance were robust to confounding: the within-family estimates from sibling fixed effects models overlapped with the between-person effects. Finally, childhood personality was equally predictive of educational performance across ages and genders. Although family background is influential for academic achievement, it does not confound associations with personality. Childhood personality traits reflect unbiased and consistent individual differences in educational potential.
SanAntonioApp
Authors: Navas Rafael , Erasun Vanessa , Banega Rafael , Sapriza Gonzalo , Saracho Andrés , Gamazo Pablo
Published: November 2022

Agricultural irrigation projects require information on the quantity and frequency of streamflow to design irrigation systems. On the one hand, this information is obtained from gauging stations or hydrologic models. On the other hand, there are few gauging stations, and hydrologic models are expensive to implement, especially for small irrigation projects. This work proposes a method for estimating spatially distributed Flow Duration Curves (FDC), and describes the SanAntonioApp interactive application with open access and repository, which is used to share the results of this work. The proposed framework uses three years of records of a rich hydrometeorological network to implement, optimise and cross-validate the WFLOW-HBV distributed hydrologic model in San Antonio Creek (Salto, Uruguay). Then, FDC are generated by extending the simulation period with the long records of an agro-climatological station (30 years). The results of this work contribute to evaluate the water availability of the San Antonio catchment and provide information on how often this availability is guaranteed. In addition, the application allows estimating the probability of exceedance of the daily streamflow for a given month and location. This function could be used to estimate the environmental flow established in the current water regulation in Uruguay.
IMPLEMENTASI STRATEGI DINAS PEMBERDAYAAN PEREMPUAN DAN PERLINDUNGAN ANAK (DP3A) DALAM MENEKAN PENINGKATAN ANGKA KEKERASAN SEKSUAL ANAK DI KABUPATEN TANGERANG, INDONESIA
Authors: Dewi Rahma Sita
Published: November 2022

Child sexual violence there are still many cases of violence, namely as many as 72 victims of sexual violence against children. This study aims to determine the implementation of the Office of Women's Empowerment and Child Protection strategy in suppressing the increase in child sexual violence in Tangerang Regency. The research method used is descriptive qualitative research and analyzed by descriptive analysis. Based on the data analysis, it can be concluded that the implementation of strategies that can be carried out by the Office of Women's Empowerment and Child Protection in suppressing the increase in the number of child sexual violence in Tangerang Regency is by analyzing programs, budgets, and procedures. The first program is several PATBM in the village or village has not been running. Secondly, advocacy socialization through BK/BP teachers has been given socialization by service to BK/BP teachers, but only part of the socialization has not been right on target, namely all students. Third, socialization to the community through community leaders where community leaders have never received directions from the department or village. The budget still has its budget limitations. There are still programs or activities whose implementation has not been to the plan due to budget limitations. In the implementation of Standard Operating Procedures (SOP), some problems are still victims of violence who are less cooperative in handling cases of child sexual violence.
A evolução da contabilidade no brasil e sua relevância para os negócios
Authors: Colares Samuel Rodrigues , Silva Alexandre Danley Falcon Souza da , Santos Maria Carolina de Carvalho do , Roberto José Carlos Alves , Cavalcante Zuila Paulino
Published: November 2022

A contabilidade, ao longo dos anos, deixou de ser vista como um método apenas de escrituração de acontecimentos e registros, que tinha a intenção de mensurar tributos e resultados monetários. Tornando-se, atualmente, relevante para a sobrevivência da organização, pois é uma relevante ferramenta que promove a estruturação e gerenciamento. Nesse contexto, o presente artigo tem como questão norteadora: como a evolução dos processos contábeis podem contribuir com a maximização dos resultados organizacionais? Desta forma, objetiva-se descrever a evolução da contabilidade no Brasil, visando demonstrar a sua relevância para as organizações. Para isso, a metodologia utilizada foi a pesquisa bibliográfica, embasada em artigos e livros acerca dos fatos que marcaram a história da contabilidade nos territórios brasileiros. Por fim, nota-se que a contabilidade oferece maior transparência e informações confiáveis, agregando uma série de vantagens aos negócios.
A Scoping Review of Voice-Related Patient-Reported Outcome Measures in Korea
Authors: Lee Jeong Min , Jung Soo Yeon , Kim Han Su
Published: November 2022

Background and Objectives The purpose of this study is to provide a resource for clinicians and researchers regarding voice-related patient-reported outcome measures (PROMs) available in the Korean Language.Subjects and Method A systematic search for Korean voice-related PROMs was conducted in December 2021. The search used five electronic databases, including PubMed, Cumulative Index of Nursing and Allied Health Literature, Science Direct, Research Information Sharing Service, DataBase and Periodical Information Academic. Furthermore, reference lists from PROMs-related articles and voice-related journals were independently searched. Search terms emphasized “voice disorders,” “patient-reported,” and “instruments” both in English and Korean. Three independent investigators screened the electronic search results for relevance and selected articles based on the study’s inclusion and exclusion criteria.Results A total of 164 studies assessing Korean voice-related PROMs were identified, and this list was narrowed to 14 PROMs based on the predetermined inclusion and exclusion criteria. Fourteen voice-related PROMs validated in Korean were selected for a comprehensive review and were categorized as general voice handicap measures, symptom-oriented measures, socioemotional measures, and quality of life measures. Additionally, the characteristics of each of the fourteen Korean voice-related PROMs were summarized in evidence tables.Conclusion A total of fourteen Korean voice-related PROMs are available for clinical and research use; however, care must be taken when clinicians and researchers consider which instrument(s) to use. The current review provides a useful summary and could serve as a guide for future systematic reviews on Korean voice-related PROMs.
Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis
Authors: Spedicati Mattia , Ruocco Gerardina , Zoso Alice , Mortati Leonardo , Lapini Andrea , Delledonne Andrea , Divieto Carla , Romano Veronica , Castaldo Clotilde , Di Meglio Franca , Nurzynska Daria , Carmagnola Irene , Chiono Valeria
Published: November 2022

In vitro models of pathological cardiac tissue have attracted interest as predictive platforms for preclinical validation of therapies. However, models reproducing specific pathological features, such as cardiac fibrosis size (i.e., thickness and width) and stage of development are missing. This research was aimed at engineering 2D and 3D models of early-stage post-infarct fibrotic tissue (i.e., characterized by non-aligned tissue organization) on bioartificial scaffolds with biomimetic composition, design, and surface stiffness. 2D scaffolds with random nanofibrous structure and 3D scaffolds with 150 µm square-meshed architecture were fabricated from polycaprolactone, surface-grafted with gelatin by mussel-inspired approach and coated with cardiac extracellular matrix (ECM) by 3 weeks culture of human cardiac fibroblasts. Scaffold physicochemical properties were thoroughly investigated. AFM analysis of scaffolds in wet state, before cell culture, confirmed their close surface stiffness to human cardiac fibrotic tissue. Following 3 weeks culture, biomimetic biophysical and biochemical scaffold properties triggered the activation of myofibroblast phenotype. Upon decellularization, immunostaining, SEM and two-photon excitation fluorescence microscopy showed homogeneous decoration of both 2D and 3D scaffolds with cardiac ECM. The versatility of the approach was demonstrated by culturing ventricular or atrial cardiac fibroblasts on scaffolds, thus suggesting the possibility to use the same scaffold platforms to model both ventricular and atrial cardiac fibrosis. In the future, herein developed in vitro models of cardiac fibrotic tissue, reproducing specific pathological features, will be exploited for a fine preclinical tuning of therapies.
Promising drugs and treatment options for pediatric and adolescent patients with Hodgkin lymphoma
Authors: De Re Valli , Repetto Ombretta , Mussolin Lara , Brisotto Giulia , Elia Caterina , Lopci Egesta , d’Amore Emanuele S. G. , Burnelli Roberta , Mascarin Maurizio
Published: November 2022

Currently-available therapies for newly-diagnosed pediatric and adolescent patients with Hodgkin lymphoma result in >95% survival at 5 years. Long-term survivors may suffer from long-term treatment-related side effects, however, so the past 20 years have seen clinical trials for children and adolescents with HL gradually abandon the regimens used in adults in an effort to improve this situation. Narrower-field radiotherapy can reduce long-term toxicity while maintaining good tumor control. Various risk-adapted chemo-radiotherapy strategies have been used. Early assessment of tumor response with interim positron emission tomography and/or measuring metabolic tumor volume has been used both to limit RT in patients with favorable characteristics and to adopt more aggressive therapies in patients with a poor response. Most classical Hodgkin’s lymphoma relapses occur within 3 years of initial treatment, while relapses occurring 5 years or more after diagnosis are rare. As the outcome for patients with relapsed/refractory classical Hodgkin lymphoma remains unsatisfactory, new drugs have been proposed for its prevention or treatment. This review summarizes the important advances made in recent years in the management of pediatric and adolescent with classical Hodgkin lymphoma, and the novel targeted treatments for relapsed and refractory classical Hodgkin lymphoma.
Global miRNA expression reveals novel nuclear and mitochondrial interactions in Type 1 diabetes mellitus
Authors: Ferraz Rafaella Sousa , Santos Lucas Cauê Bezerra , da-Silva-Cruz Rebecca Lais , Braga-da-Silva Cintia Helena , Magalhães Leandro , Ribeiro-dos-Santos Arthur , Vidal Amanda , Vinasco-Sandoval Tatiana , Reis-das-Mercês Laís , Sena-dos-Santos Camille , Pereira Adenilson Leão , Silva Lilian Souza D’Albuquerque , Melo Franciane T. Cunha de , Souza Ana Carolina C. Braga de , Leal Valéria S. Galvão , Figueiredo Priscila B. Barbosa de , Neto João F. Abrahão , Moraes Lorena Vilhena de , Lemos Gabriela Nascimento de , Queiroz Natércia Neves Marques de , Felício Karem Miléo , Cavalcante Giovanna C. , Ribeiro-dos-Santos Ândrea , Felício João Soares
Published: November 2022

Background

Considering the potential role of miRNAs as biomarkers and their interaction with both nuclear and mitochondrial genes, we investigated the miRNA expression profile in type 1 diabetes (T1DM) patients, including the pathways in which they are involved considering both nuclear and mitochondrial functions.

Methods

We analyzed samples of T1DM patients and control individuals (normal glucose tolerance) by high throughput miRNA sequencing (miRNome). Next, five miRNAs – hsa-miR-26b-5p, hsa-let-7i-5p, hsa-miR-143-3p, hsa-miR-501-3p and hsa-miR-100-5p – were validated by RT-qPCR. The identification of target genes was extracted from miRTarBase and mitoXplorer database. We also performed receiver operating characteristic (ROC) curves and miRNAs that had an AUC > 0.85 were considered potential biomarkers.

Results

Overall, 41 miRNAs were differentially expressed in T1DM patients compared to control. Hsa-miR-21-5p had the highest number of predicted target genes and was associated with several pathways, including insulin signaling and apoptosis. 34.1% (14/41) of the differentially expressed miRNAs also targeted mitochondrial genes, and 80.5% (33/41) of them targeted nuclear genes involved in the mitochondrial metabolism. All five validated miRNAs were upregulated in T1DM. Among them, hsa-miR-26b-5p showed AUC>0.85, being suggested as potential biomarker to T1DM.

Conclusion

Our results demonstrated 41 DE miRNAs that had a great accuracy in discriminating T1DM and control group. Furthermore, we demonstrate the influence of these miRNAs on numerous metabolic pathways, including mitochondrial metabolism. Hsa-miR-26b-5p and hsa-miR-21-5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation.