bluuebunny/crossref_metadata_2025 huggingface dataset:
A nutrition-focused review of the interventions in US-living Latino communities with type II diabetes
Authors: Guirette Mélanie , Sevilla-Gonzalez Magdalena , Balaguera Maureen , Caballero Augusto Enrique
Published: September 2024

Type 2 diabetes (T2D) is a chronic, debilitating disease that disproportionally affects the Hispanic/Latino community residing in the United States. Optimal nutrition therapy is fundamental to the proper management of T2D and must be culturally adapted to facilitate permanent behavior change in this population. This review selected and assessed the nutrition components of interventions aimed to improve T2D outcomes in US-based Latinos/Hispanics, published from 2002 to 2023. An overview of the participant characteristics, nutrition intervention, and dietary assessment and outcomes is included. Nutrition interventions in this community benefit from the inclusion of bicultural registered dietitian nutritionist (RDNs) to assure the counseling team promotes culturally tailored nutrition recommendations based on current dietary guidelines. Nutrition assessment and outcomes should be captured with the use of validated dietary assessment tools and dietary quality indices appropriate to their target population. Standardizing these practices will facilitate intervention comparability and replicability and ultimately better target the needs of this community.
Amino acid requirements of the infant: the amino acid composition of human breast milk
Authors: Moughan Paul J. , Deglaire Amelie , Yan Yalu , Wescombe Philip , Lim Wen Xin Janice , Stroebinger Natascha , Duan Sufang , Szeto Ignatius Man-Yau , Hodgkinson Suzanne
Published: September 2024

The recommended amino acid requirements of the infant are based on the amino acid composition of mature human breast milk. The amino acid composition of breast milk is usually determined following either acid or alkaline (for tryptophan) hydrolysis. For accuracy, however, the known effect of hydrolysis time on amino acid composition should be accounted for. Also, ideally the amino acid composition of breast milk should be given in units of digested (assumed to be absorbed) amino acids. A review of the literature is presented which gives mean total amino acid concentrations in mature human milk (n = 26 studies), mean hydrolysis correction factors (n = 3 studies) and mean true ileal amino acid digestibility coefficients (n = 3 studies, suckling piglet). There were differences between the estimates of amino acid concentration corrected for hydrolysis time and digestibility, and current FAO (2013) recommendations that were not corrected for these factors. The values based on the published literature up until 2023 (mg/g true protein) corrected for hydrolysis time and digestibility gave higher values (more than 16% higher) for leucine, lysine and threonine, and considerably higher values (greater than 30%) for histidine and tryptophan. Current recommendations may need revision.
Non-surgical nursing care for tumor patients: an overview of sedation, analgesia, and recent innovations
Authors: Wei Wei , Wang Pan , Qing Pan , Li Zhang , He Qi
Published: September 2024

With the increasing prevalence of tumors, effective symptom management has emerged as a cornerstone of patient care. While surgical interventions remain pivotal, non-surgical nursing methods have gained prominence in providing relief from pain, discomfort, and other tumor-related symptoms. This review delves into the various non-surgical approaches employed, emphasizing tumor sedation and analgesia. We discuss the array of non-pharmacological and pharmacological strategies, shedding light on their indications, contraindications, and potential side effects. Furthermore, the importance of addressing individual differences in pain perception and the ethical considerations in symptom management are highlighted. We conclude by providing insights into the recent innovations in the field, emphasizing the need for personalized and comprehensive care to enhance patients’ quality of life. Tumor sedation, Tumor analgesia, Non-surgical nursing care, Pain management, Non-pharmacological interventions, Palliative care, Recent innovations, Symptom management.
Ultrasound-based radiomics nomogram for predicting HER2-low expression breast cancer
Authors: Zhang Xueling , Wu Shaoyou , Zu Xiao , Li Xiaojing , Zhang Qing , Ren Yongzhen , Qian Xiaoqin , Tong Shan , Li Hongbo
Published: September 2024

Purpose

Accurate preoperative identification of Human epidermal growth factor receptor 2 (HER2) low expression breast cancer (BC) is critical for clinical decision-making. Our aim was to use machine learning methods to develop and validate an ultrasound-based radiomics nomogram for predicting HER2-low expression in BC.

Methods

In this retrospective study, 222 patients (108 HER2-0 expression and 114 HER2-low expression) with BC were included. The enrolled patients were randomly divided into a training cohort and a test cohort with a ratio of 8:2. The tumor region of interest was manually delineated from ultrasound image, and radiomics features were subsequently extracted. The features underwent dimension reduction using the least absolute shrinkage and selection operator (LASSO) algorithm, and rad-score were calculated. Five machine learning algorithms were applied for training, and the algorithm demonstrating the best performance was selected to construct a radiomics (USR) model. Clinical risk factors were integrated with rad-score to construct the prediction model, and a nomogram was plotted. The performance of the nomogram was assessed using receiver operating characteristic curve and decision curve analysis.

Results

A total of 480 radiomics features were extracted, out of which 11 were screened out. The majority of the extracted features were wavelet features. Subsequently, the USR model was established, and rad-scores were computed. The nomogram, incorporating rad-score, tumor shape, border, and microcalcification, achieved the best performance in both the training cohort (AUC 0.89; 95%CI 0.836-0.936) and the test cohort (AUC 0.84; 95%CI 0.722-0.958), outperforming both the USR model and clinical model. The calibration curves showed satisfactory consistency, and DCA confirmed the clinical utility of the nomogram.

Conclusion

The nomogram model based on ultrasound radiomics exhibited high prediction value for HER2-low BC.
The association between nutritional status measured by body mass index and outcomes in the pediatric intensive care unit
Authors: Pournasiri Zahra , Bakhtiary Mahsa , Nikparast Ali , Hashemi Seyedeh Masumeh , Narjes Ahmadizadeh Seyyedeh , Behzad Azita , Asghari Golaleh
Published: September 2024

Aim/Introduction

The relationship between nutritional status upon admission to a pediatric intensive care unit (PICU) and clinical outcomes remains unclear. We examined the relationship between nutrition status, as indicated by body mass index-for-age (BMI-for-age), and clinical outcomes in the PICU.

Method

In this retrospective study at a tertiary care center, records of 1,015 critically ill children and adolescents aged one month to 18 years old with available anthropometric parameters were included. The nutritional status upon admission was determined by calculating the BMI-for-age z-score using the WHO growth charts as the reference. The participants were categorized as underweight (BMI-for-age z-score < −2), normal weight (−2 ≤ BMI-for-age z-score ≤ +1), and overweight/obese (BMI-for-age z-score > +1). Multi-variate odds ratios (OR) with 95% confidence intervals (CI) were used to investigate the association between malnutrition (being underweight and overweight/obese) and odds of Prolonged PICU stay (≥7 days) and PICU mortality after controlling for descriptive characteristics, Glasgow Coma Scale score status, fluctuations in serum sodium, and acute kidney injury confounders.

Results

The proportions of patients in underweight, normal weight, and overweight/obese categories were 34.2%, 45.8%, and 20%, respectively. During the study period, 21.5% of patients had prolonged PICU stay, and 5.6% of patients in PICU died. Compared to normal-weight patients, underweight patients had higher odds of prolonged PICU stay (OR: 1.52; 95% CI: 1.05–2.22) and PICU mortality (OR: 2.12; 95% CI: 1.22–4.01). Age- and gender-stratified full-adjusted analysis showed that the increased odds of prolonged PICU stay remained significant among underweight boys and underweight individuals aged 5–19 years old. Furthermore, the increased odds of PICU mortality remained significant among underweight individuals aged 2–5 years old. However, being overweight or obese during PICU admission did not demonstrate a significant association with our outcomes in the total sample or subgroup analysis.

Conclusion

Our findings showed that PICU patients who were underweight had higher odds of prolonged PICU stay and PICU mortality than their normal-weight counterparts. This underscores the importance of closely monitoring underweight patients in the PICU upon admission in order to improve clinical outcomes.
Extracellular vesicles affecting embryo development in vitro: a potential culture medium supplement
Authors: Xue Yamei , Zheng Haixia , Xiong Yuping , Li Kun
Published: September 2024

Extracellular vesicles (EVs) are nanometer-sized lipid bilayer vesicles released by cells, playing a crucial role in mediating cellular communication. This review evaluates the effect of EVs on early embryonic development in vitro by systematically searching the literature across three databases, Embase, PubMed, and Scopus, from inception (Embase, 1947; PubMed, 1996; and Scopus, 2004) to 30 June 2024. A total of 28 studies were considered relevant and included in this review. The EVs included in these investigations have been recovered from a range of sources, including oviduct fluid, follicular fluid, uterine fluid, seminal plasma, embryos, oviduct epithelial cells, endometrial epithelial cells, amniotic cells, and endometrial-derived mesenchymal stem cells collected primarily from mice, rabbits, cattle and pigs. This diversity in EV sources highlights the broad interest and potential applications of EVs in embryo culture systems. These studies have demonstrated that supplementation with EVs derived from physiologically normal biofluids and cells to the embryo culture medium system has positive effects on embryonic development. Conversely, EVs derived from cells under pathological conditions have shown a negative impact. This finding underscores the importance of the source and condition of EVs used in culture media. Further, the addition of EVs as a culture medium supplement holds significant therapeutic potential for optimizing in vitro embryo culture systems. In conclusion, this evaluation offers a thorough assessment of the available data on the role of EVs in embryo culture media and highlights the potential and challenges of using EVs in vitro embryo production.
Metabolomics and quantitative analysis to determine differences in the geographical origins and species of Chinese dragon’s blood
Authors: Sun Xiuting , Huang Qing , Wu Mingsong , He Liu , Zhao Xiangsheng , Yang Xinquan
Published: September 2024

Objective

The aim of this study was to comprehensively analyze the differences in Chinese dragon’s blood (CDB), specifically Dracaena cochinchinensis and Dracaena cambodiana, from different geographical origins.

Methods

Metabolomic analysis of CDB was performed by liquid chromatography-tandem mass spectrometry (LC–MS/MS). A reliable ultrahigh-performance liquid chromatography method with a photodiode array detector (UHPLC-PDA) was developed and applied for the quantitative analysis of 12 phenolic compounds in 51 batches of samples.

Results

A total of 1394 metabolites were detected, of which 467 were identified as differentially accumulated metabolites. Multivariate analysis revealed that both origin and species had an effect on the composition of CDB, with greater variation between species. 19 phenolic compounds were selected as quality markers to distinguish D. cochinchinensis (Hdsp) from D. cambodiana (Hdca), and oppositin and spinoflavanone a were identified as quality markers to discriminate D. cochinchinensis samples from Hainan (Hdsp) and Guangxi Provinces (Gdc). Quantitative analysis indicated that four phenolic compounds, including loureirin D, 4H-1-benzopyran-4-one,2,3-dihydro-3,5,7-trihydroxy-3-[(4-methoxyphenyl)methyl]-,(R)-, loureirin B, and pterostilbene, showed significant differences between Gdc and Hdsp. Additionally, five phenolic compounds, namely resveratrol, loureirin D, pinostilbene, 4H-1-benzopyran-4-one,2,3-dihydro-3,5,7-trihydroxy-3-[(4-methoxyphenyl)methyl]-, (R)-, and loureirin B, exhibited significant differences between Hdsp and Hdca.

Conclusion

There are significant differences in the quality of CDB from different geographical origins and species, which lays the foundation for the in-depth development and utilization of different sources of CDB.
Caffeic acid O-methyltransferase from Ligusticum chuanxiong alleviates drought stress, and improves lignin and melatonin biosynthesis
Authors: Huang Enxia , Tang Jie , Song Simin , Yan Han , Yu Xinyi , Luo Chenlu , Chen Yineng , Ji Huiyue , Chen Anqi , Zhou Jiayu , Liao Hai
Published: September 2024

Drought stress is a major constraint on plant growth and agricultural productivity. Caffeic acid O-methyltransferase (COMT), an enzyme involved in the methylation of various substrates, plays a pivotal role in plant responses to abiotic stress. The involvement of COMTs in drought response, particularly through the enhancement of lignin and melatonin biosynthesis, remains poorly understood. In this study, LcCOMT was firstly proposed to be associated with the biosynthesis of both lignin and melatonin, as demonstrated through sequence comparison, phylogenetic analysis, and conserved motif identification. In vitro enzymatic assays revealed that LcCOMT effectively methylates N-acetylserotonin to melatonin, albeit with a higher Km value compared to caffeic acid. Site-directed mutagenesis of residues Phe171 and Asp269 resulted in a significant reduction in catalytic activity for caffeic acid, with minimal impact on N-acetylserotonin, underscoring the specificity of these residues in substrate binding and catalysis. Under drought conditions, LcCOMT expression was significantly upregulated. Overexpression of LcCOMT gene in Arabidopsis plants conferred enhanced drought tolerance, characterized by elevated lignin and melatonin levels, increased chlorophyll and carotenoid content, heightened activities of antioxidant enzymes peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD), and reduced malondialdehyde (MDA) and hydrogen peroxide (H2O2) accumulation. This study is among the few to demonstrate that COMT-mediated drought tolerance is achieved through the simultaneous promotion of lignin and melatonin biosynthesis. LcCOMT represents the first functionally characterized COMT in Apiaceae family, and it holds potential as a target for genetic enhancement of drought tolerance in future crop improvement strategies.
Influence of social cleavage and media usage on political behavior: a case of Pakistan
Authors: Anum Isma , Zulfiqar Amna
Published: September 2024

Increasingly media provides ample opportunities for the audiences to make media choices and form different levels of exposure along political lines. Predominately, Pakistan’s media is recognized as an irreplaceable tool in sparking change in the political landscape, forgoing national-regional identities, and bridging social gaps. Due to recent technological advancements citizens’ media usage brought changes in the political behavior of citizens regarding party choices and voting behavior. Such changes in the political behavior of citizens affect decision making which is influenced by social cleavage of education, gender, and age. However, contrary to similar historical changes, these advances have widened rather than narrowed societal cleavages. The objective of the paper is to explore the influence of social cleavage and media usage on political behavior of students and faculty in Pakistan specifically NUML university, Islamabad. This research explores how social cleavage and recent advances in digital media access changed the political behavior of faculty and students of NUML university. The paper employed survey-based research with a sample of 250 faculty members and students of NUML, Islamabad. According to results, it is concluded that social cleavage of education, age, and gender plays a vital role in transforming the political behavior of both faculty members and students. Likewise, persistent use of social media portrays positive political participation along with accountable voting behavior, whereby males are more active in participating in political activities as compared to females. The paper has policy implications for a one-dimensional media approach for ignoring solutions to political problems and understanding citizenship rights. Focused and well-defined policies are required to bring youth back to broadcasting media.
Injecting competition into online programming and Chinese- English translation classrooms
Authors: Wan Yinjia , Lian Jian , Zhou Yanan
Published: September 2024

The introduction of competition has the potential to enhance the efficacy of students' learning performance. Nevertheless, there have been contradictory findings about the impact of intergroup competition on students' learning performance and engagement. Therefore, further comprehensive investigations for this problem are necessary. In order to bridge this gap, the present study seeks to ascertain the efficacy of intergroup competition in relation to students' academic performance and motivation. Consequently, we present the concept of intergroup competition and implement it within the context of an online programming course and an online Chinese-English translation course. The participants of this study consist of sophomore students majoring in Computer Science and English. Initially, a total of 108 sophomore students majoring in Computer Science participated. Then, a total of 100 sophomore students majoring in English participated. A quasi-experimental study was subsequently undertaken to compare students from two courses, which are online programming and Chinese-English translation, assigning them to an experimental group and a comparison group, respectively. Then, we conducted independent samples t-tests to measure the difference between the academic performance of the two group of students from two courses. The results indicate that both groups of students who were exposed to the intergroup competition mechanism demonstrated considerably higher levels of academic performance and engagement compared to the other group of students. The findings indicate that the competition mechanism, has the potential to be a beneficial instrument for enhancing both students' learning performance and motivation.
A perspective review on the role of engine sound in speed perception and control: state of the art and methodological suggestions
Authors: Prpic Valter , Gherri Elena , Lugli Luisa
Published: September 2024

In this review we focus on the role of in-car sound, specifically the artificial engine sounds, on drivers’ speed perception and control, a topic that has received little attention so far. Previous studies indicate that removing or reducing engine sound leads drivers to underestimate speed and, consequently, to drive faster. Furthermore, evidence suggests that specific sound frequencies could play a role in this process, highlighting the importance of in-car sound features. First, we show that the amount of research in the field is scarce and rather outdated, and that this is largely due to the fact that industrial research is subject to very few publications. Then, we examine benefits and limitations of different research paradigms used and we propose a protocol to investigate systematically the phenomenon. In particular, we argue for the benefits of a wider use of psychophysical methods in speed perception, a field that has been typically explored by means of driving simulation. Finally, we highlight some methodological and statistical limitations that might impact the interpretation of the evidence considered. Our methodological considerations could be particularly useful for researchers aiming to investigate the impact of sound on speed perception and control, as well as for those involved in the design of in-car sounds. These are particularly relevant for the design of electric vehicles, which represent a challenge but also the ideal testing ground to advance the knowledge in the field.
Cognitive ability, gender, and well-being in school contexts: longitudinal evidence from Sweden
Authors: Boman Björn , Wiberg Marie
Published: September 2024

While well-being does generally constitute a moderate predictor of school achievement, research on the predictive validity of cognitive ability for well-being in school contexts remains scant. The current study analyzed longitudinal relations between cognitive ability measured at age 13 (Grade 6) and well-being measured at age 18 (Grade 12, valid N = 2,705) in a Swedish sample, using several multivariate model techniques. The results indicate that cognitive ability was not a statistically significant predictor when several predictors were entered in a multiple regression model. However, gender was a significant covariate as girls and young women have a substantially lower degree of self-reported well-being. This casts light on the limitations of cognitive ability as a construct for some non-cognitive outcomes, at least in shorter and narrower spatial–temporal contexts.
The influence of positivity and self-efficacy beliefs on family functioning among young adults in Italy and Colombia
Authors: Baiocco Roberto , Pistella Jessica , Gomez Plata Maryluz , Morelli Mara , Isolani Stefano , Zapata Zabala Maryoris Elena , Cabas Hoyos Kattia Paola , Uribe Tirado Liliana Maria , Ruiz Garcia Marcela Sucel , Barbosa Carmelina Paba , Zuffiano Antonio , Gerbino Maria , Laghi Fiorenzo , Pastorelli Concetta
Published: September 2024

Background

Research suggests that positivity and self-efficacy beliefs may impact adaptive behavior and developmental outcomes, such as social adjustment and subjective wellbeing. The present study explored the effect of positive dimensions (positivity and self-efficacy beliefs) and individual characteristics (gender, type of country, age, and sexual orientation) on family cohesion and flexibility in a group of Colombian and Italian young adults.

Method

An online survey was administered to 949 Colombian and 2,073 Italian people aged between 18 and 40 years (Mage = 24.3; SDage = 4.5; 67% women). A mediational model was performed to test the influence of positivity on family functioning via the mediational role of self-efficacy beliefs, analyzing the moderated effects of gender, type of country, sexual orientation, and age.

Results

Filial self-efficacy mediated the effect of positivity on family functioning, showing stronger paths in men and Colombian participants than in women and Italian counterparts. Regulatory self-efficacy mediated the associations between positivity and family functioning for both genders and types of countries.

Conclusion

The results suggest that positivity and self-efficacy beliefs may allow families to engage in more adaptive family functioning across countries and genders. Further research should focus on implications from a cross-national perspective to examine other culture-specific factors that may impact family adjustment.
Emotion and cognition: on the cognitive processing model of nostalgia
Authors: Cao Shurong
Published: September 2024

Nostalgia is a common emotional phenomenon, but its complexity has resulted in a limited understanding and interpretation. This study, grounded in emotional cognitive science, develops a cognitive processing model of nostalgia, encompassing its triggering mechanism, cognitive processes, and effects. The analysis indicates that nostalgia functions as an adaptive mechanism for individuals with deficiencies in belongingness and low-avoidance tendencies, helping them cope with disruptions in self-continuity by forging symbolic social bonds in a distant and idealized timespace. Essentially, nostalgia allows individuals to reconstruct alternate systems of meaning and value, which serve as references for defining self-worth and identity. This study advances the understanding of the complex cognitive processing involved in nostalgia and also provides an important reference for the study of complex emotions.
Development and validation of the Japanese version of the Auckland individualism and collectivism scale: relationship between individualism/collectivism and mental health
Authors: Noda Shota , Okawa Sho , Kasch Chantal , Vogelbacher Christoph , Lindsay Cameron E. , Nishiuchi Motohiro , Kobayashi Maaya , Hofmann Stefan G.
Published: September 2024

Background

This study developed the Japanese version of the Auckland Individualism and Collectivism Scale (J-AICS), examined its reliability and validity, and explored the associations between its factors (compete, unique, responsibility, advice, and harmony) along with variables related to mental health in the Japanese population.

Methods

We recruited 476 Japanese participants from the general population. Participants completed the J-AICS along with questionnaires pertaining to culture and mental health.

Results

Confirmatory factor analysis indicated the correlated five-factor model showed a good fit to the data. The Cronbach’s α and McDonald’s ω coefficients were high for the individualism, collectivism, compete, unique, and advice factors, but low for the responsibility and harmony factors. Convergent validity was supported by significant relationships between culture-related variables. A one-way analysis of variance revealed the low individualism/collectivism cluster had higher loneliness and lower satisfaction with life than the high individualism and collectivism clusters. The multiple regression analyses showed that the responsibility factor was significantly and negatively associated with mental health concerning anxiety and depressive symptoms, loneliness, and satisfaction with life. In addition, the harmony factor was significantly and positively associated with the mental health.

Conclusion

These findings demonstrate sufficient validity of the J-AICS; however, reliability was insufficient for responsibility and harmony. Further, responsibility was positively associated with mental health and harmony was negatively associated with mental health.
Prevalence and disparities in receiving medical advice to quit tobacco use in the US adult population
Authors: Chandra Monalisa , Talluri Rajesh , Fokom Domgue Joel , Shete Sanjay
Published: September 2024

Introduction

Evidence suggests that advice from health care professionals (HCP) increases the likelihood of quit attempts and successful quitting of tobacco use. However, previous studies primarily focussed on cigarette smoking and did not include all forms of tobacco products. This study aimed to investigate the prevalence and disparities in receiving HCP’s advice to quit tobacco use (combustible or noncombustible) in the US adult population.

Methods

Using the 2022 National Health Information Survey (NHIS) data, we examined 4,424 adults who reported (i) any tobacco product use within the past 12 months and (ii) having seen an HCP within the past 12 months. The outcome variable included the receipt of advice to quit tobacco use from an HCP, and predictors included sociodemographic variables. Weighted prevalence estimates were calculated, and multivariable regression analyses were conducted.

Results

Over 38% of tobacco users who visited an HCP were advised to quit. The odds of receiving such advice were lower among Hispanics (AOR: 0.625; 95% confidence interval (CI) [0.464–0.843];p = 0.002), males (AOR: 0.767; 95% CI [0.659–0.893], p = 0.001), those above the poverty level (AOR: 0.795; 95% CI [0.641–0.987];p = 0.037), foreign-born (AOR: 0.664; 95% CI [0.496–0.888]; p = 0.006), those with a bachelor’s degree or higher educational level (AOR: 0.477; 95% CI [0.349–0.653]; p < 0.001) and those aged less than 45 years (AOR: 0.404; 95% CI: [0.344–0.473]; p < 0.001).

Conclusion

The prevalence of receiving HCP’s advice to quit tobacco use remains suboptimal and disparate among sociodemographic groups. Our findings call for strategic implementation of the USPHS’s recommendation on treating tobacco use and taking further actions to equip HCPs with the training and resources needed to provide appropriate advice to quit tobacco.
Defense mechanisms of Salmonella against antibiotics: a review
Authors: Punchihewage-Don Anuradha Jeewantha , Ranaweera Priyanka Nilmini , Parveen Salina
Published: September 2024

Salmonella is a foodborne pathogenic bacterium that causes salmonellosis worldwide. Also, Salmonella is considered a serious problem for food safety and public health. Several antimicrobial classes including aminoglycosides, tetracyclines, phenols, and β-Lactams are used to treat Salmonella infections. Antibiotics have been prescribed for decades to treat infections caused by bacteria in human and animal healthcare. However, intensive use of antibiotics resulted in antibiotic resistance (AR) among several foodborne bacteria including Salmonella. Furthermore, multi-drug resistance (MDR) of Salmonella has increased dramatically. In addition to MDR Salmonella, extensively drug resistant (XDR) as well as pan drug resistant (PDR) Salmonella were reported globally. Therefore, increasing AR is becoming a serious universal public health crisis. Salmonella developed many mechanisms to ensure its survival against antimicrobials. The most prominent defense mechanisms against these antibiotics include enzymatic inactivation, expelling drugs from the cell through efflux pumps, altering the structure of drugs, and changing or protecting the targets of drugs. Additionally, the formation of biofilms and plasmid-mediated AR by Salmonella, enhancing its resistance to various antibiotics, making it a challenging pathogen in both healthcare and food industry settings. This review focuses exclusively on providing a detailed overview of the mechanisms of AR in Salmonella.
Smoking cessation assistance among pneumologists and thoracic surgeons in Switzerland: a national survey
Authors: Minervini Fabrizio , Kestenholz Peter , Rassouli Frank , Pohle Susanne , Mayer Nora
Published: September 2024

Objective

Smoking, with a prevalence of about 25%–30% in Switzerland, is proven to cause major systemic, avoidable diseases including lung cancer, increasing societies morbidity and mortality. Diverse strong quitting smoking recommendations have been made available providing advice facilitating smoking cessation globally. In other European countries like Germany, clinical practice guidelines for smoking cessation services have been implemented. However, in Switzerland, there is still no national consensus on a comprehensive smoking cessation program for lung cancer patients nor on the adequate provider. Our primary aim was to assess the current status of smoking cessation practice among specialists, mainly involved in lung cancer care, in Switzerland in order to uncover potential shortcomings.

Material and methods

A self-designed 14-items questionnaire, which was reviewed and approved by our working group consisting of pneumologists and thoracic surgeons, on demographics of the participants, the status of smoking cessation in Switzerland and specialists' opinion on smoking cessation was sent to thoracic surgeons and pneumologists between January 2024 and March 2024 via the commercially available platform www.surveymonkey.com. Data was collected and analysed with descriptive statistics.

Results

Survey response rate was 22.25%. Smoking cessation was felt to positively affect long term survival and perioperative outcome in lung cancer surgery. While 33 (37.08%) physicians were offering smoking cessation themselves usually and always (35.96%), only 12 (13.48%) were always referring their patients for smoking cessation. Patient willingness was clearly identified as main factor for failure of cessation programs by 63 respondents (70.79%). Pneumologists were deemed to be the most adequate specialist to offer smoking cessation (49.44%) in a combination of specialist counselling combined with pharmaceutic support (80.90%).

Conclusion

The development of Swiss national guidelines for smoking cessation and the implementation of cessation counselling in standardized lung cancer care pathways is warranted in Switzerland to improve long-term survival and perioperative outcome of lung cancer patients.
Workplace happiness in architectural companies in the city of Valencia: a gender comparison
Authors: Rodríguez-Leudo Ana Lucía , Navarro-Astor Elena
Published: September 2024

Introduction

How to make work life increasingly meaningful and ensuring that business actions aim at improving quality of life is a trending topic. Yet, it has not often been studied within architectural firms, that play a crucial role in achieving sustainable development goals, especially those related to equity, equality, and the creation of pleasant work environments. This study aims to identify whether there are gender differences in the perception and levels of workplace happiness of individuals working within architectural companies in Valencia (Spain).

Methods

A mixed methodology based on qualitative and quantitative data has been applied with a sample of 201 workers from 60 practices.

Results

Participants perceive themselves as flourishing and quite happy at work. Yet, there are gender differences in the factors that motivate workplace happiness. While women prioritize the work environment, their colleagues and teams, men point out to career development. Thus, recognition, appreciation, feeling valued and goals and achievements are among the main drivers of men’s workplace happiness. In addition, women tend to experience negative emotions such as anxiety, anger, or sadness more frequently than men. Given these results, architectural companies face a considerable challenge.

Discussion

The research examines the relationship between workplace happiness and social sustainability in architectural firms, highlighting the importance of human capital for competitiveness. To promote sustainability and well-being at work, it is crucial to understand how organizational decisions impact employee well-being and to know the differences in perceptions of workplace happiness between men and women. This analysis may be of interest to the architectural firms object of this research.
Climate variability impact on groundwater quality in Small Island Developing States: Mauritius Island as a case study
Authors: Gungoa Varsha , Kebede Seifu
Published: September 2024

This study investigates the impact of climate variability on groundwater quality in Mauritius. This is achieved by analyzing the physical and chemical water quality of the five main aquifers over eleven years. Temporal variations in water quality properties were compared to the Standardised Precipitation Index (SPI), Dry Spells, the Standardised Evapotranspiration Index (SPEI), and other climate variables to gain insights into how precipitation controls groundwater quality. The results reveal that the SPI and the SPEI correlate minimally with water quality indicators. Sulphate is the only water quality indicator that showed correlations above 0.4 in aquifers 2 and 3 against a 12-month SPI. Sulphate, alongside chloride, showed what is termed ”notable correlation,” a concept defined in this paper to accommodate correlations that fall above 0.3 when assessed against global climate modes ENSO and AAO, respectively. These results signify that sulphate is the most sensitive water quality indicator to water quantity changes, notwithstanding the modesty of the correlations. Heavy storms occurring during cyclones impact groundwater quality with respect to conductivity, TDS, salinity, and nitrate, although this could not be statistically tested given the lack of water quality indicators collected on the days surrounding the storm. Therefore, the conclusion is made based on one storm event. The study revealed that individual correlations between climate indices and water quality variables are present but weak. However, the long-term trend in water quality is visible.
Potential contribution of land cover change on flood events in the Senegal River basin
Authors: Ndiaye Assane , Arnault Joël , Mbaye Mamadou Lamine , Sy Souleymane , Camara Moctar , Lawin Agnidé Emmanuel , Kunstmann Harald
Published: September 2024

The increase in flood events observed in West African countries, and often in specific river basins, can be influenced by several factors, including anthropogenic land use and land-cover changes. However, the potential contribution of land cover changes to flood events still needs to be explored, especially in West Africa. Here, the fully coupled atmosphere-hydrology WRF-Hydro system, which comprises an atmospheric model and additionally incorporates the surface, subsurface, overland flow, and channel routing, is used to investigate the potential impact of a land cover change scenario on flood events in the Senegal River basin. The simulation was performed from 2010 to 2020, with a calibration period spanning from 2011 to 2012 and a validation period from 2013 to 2020. Several skill scores, including Nash-Sutcliffe Efficiency (NSE), BIAS, and Kling-Gupta Efficiency (KGE), were utilized to assess the calibration and validation performances. Additionally, two planetary boundary layer schemes (PBL5 and PBL7) were used to determine their associated uncertainty. Our results show that the best calibration results (NSE = 0.70; KGE = 0.83; PBIAS = −7% and BE = 0.67) in the Senegal River basin are obtained with PBL5 when the calibration is performed with a SLOPE parameter 0.03. A similar good performance was also obtained for the validation with NSE = 0.74, KGE = 0.84, and PBIAS = −8%. Likewise, our findings indicate that converting savanna to woody savannas can elevate water resources, with a 2% rise in precipitation and a 4% increase in runoff. This transition also correlates with an increase in moderate flood events (3500–4000 m3/s), a decrease in severe floods (4000–5000 m3/s), and their associated occurrence of extreme floods (>5000 m3/s) in the Senegal River basin.
What Can We Do About the Climate Crisis?
Authors: Niamir Leila , Weber Elke U.
Published: September 2024

Understanding how our planet’s climate is changing because of human actions is super important if we want to keep living here. A changing climate means hotter weather, droughts, wildfires, heavy rains, storms, and floods. To fix things, we need to figure out which human activities are making the climate act this way and how we can change those activities. Everyone has a part to play—politicians, companies, engineers, and citizens. Small things like changing how we travel or use energy can help a lot. When the younger people who will inherit the planet come together and demand action on climate change, they can have a big impact. It helps when young people combine these demands with personal action, to show others that they, and lots of other people, care about this issue: by eating less red meat, using transportation wisely, pushing for changes in how businesses operate, and voting for leaders who care about the environment.
The Influence of Augmented Reality on Consumer Attitudes and Adoption Intent: Exploring Aesthetics, Playfulness, Utility and Trust
Authors: Mumtaz Muhammad Usman , Butt Asad Hassan , Khan Dr. Muhammad Naeem , Irshad Waseem
Published: September 2024

Global consumer-brand relationships are undergoing significant transformations due to technological advancements. Immersive technologies, particularly Augmented Reality (AR), are increasingly indispensable for enhancing the consumer shopping journey. Employing Partial Least Squares Structural Equation Modelling (PLS SEM), the study utilized a sample size of 178 for analysis. The findings reveal a notable willingness among consumers in Pakistan to embrace AR technology. Furthermore, the study predicts that key AR attributes such as aesthetics, playfulness, and utility have the potential to elevate the traditional shopping experience into a more engaging and immersive one. These AR characteristics exert a positive influence on consumer attitudes, which are pivotal indicators for increased sales, market share, consumer satisfaction, and loyalty. Consequently, the research underscores the allure and feasibility of novel shopping experiences with AR technology for Pakistani users.
Modeling of the Potential Distribution Areas Suitable for Olive (Olea europaea L.) in Türkiye from a Climate Change Perspective
Authors: Özdel Muhammed Mustafa , Ustaoğlu Beyza , Cürebal İsa
Published: September 2024

Türkiye is one of the first regions where olives were domesticated, and olives reflect the country’s millennia-old agricultural and cultural heritage. Moreover, Türkiye is one of the leading nations in olive and olive oil production in terms of quality and diversity. This study aims to determine the current and future distribution areas of olives, which is important for Türkiye’s socio-economic structure. For this purpose, 19 different bioclimatic variables, such as annual mean temperature (Bio1), temperature seasonality (Bio4), and annual precipitation (Bio12), have been used. The RCP4.5 and RCP8.5 emission scenarios of the CCSM4 model were used for future projections (2050 and 2070). MaxEnt software, which uses the principle of maximum entropy, was employed to determine the current and future habitat areas of the olives. Currently and in the future, it is understood that the Mediterranean, Aegean, Marmara, and Black Sea coastlines have areas with potential suitability for olives. However, the model projections indicate that the species may shift from south to north and to higher elevations in the future. Analyses indicate that the Aegean Region is the most sensitive area and that a significant portion of habitats in the Marmara Region will remain unaffected by climate change.
N-Acetylcysteine Mitigates Oxidative Stress Induced by Transplanting Lettuce Seedlings into a DFT Hydroponic System
Authors: Sakamoto Masaru , Suzuki Takahiro
Published: September 2024

Oxidative stress results from an imbalance between the production and accumulation of reactive oxygen species (ROS), which can impede plant growth under various environmental stresses. While waterlogging is a well-known inducer of oxidative stress, the effects of oxidative stress on plant roots grown using the deep flow technique (DFT) hydroponic system remain poorly understood. In this study, we demonstrate that N-acetylcysteine (NAC) enhances the growth of lettuce seedlings transplanted into a DFT system. NAC application significantly improved both shoot and root growth, with the most pronounced effects observed at a concentration of 0.3 mM. Moreover, NAC mitigated the accumulation of hydrogen peroxide in roots following transplantation. It also reduced a temporary increase in lipid peroxidation and total phenolic content in both roots and shoots. These results suggest that NAC functions as an antioxidant, alleviating oxidative stress by scavenging hydrogen peroxide in the roots. Importantly, NAC’s protective effects may extend to other hydroponically grown crops, offering broader potential for reducing oxidative stress across various cultivation systems.
Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review
Authors: Badia Josep M. , Amador Sara , González-Sánchez Carmen , Rubio-Pérez Inés , Manuel-Vázquez Alba , Juvany Montserrat , Membrilla Estela , Balibrea José M. , Guirao Xavier
Published: September 2024

Background: While selective use of antibiotics for infected pancreatic necrosis (IPN) in acute pancreatitis (AP) is recommended, studies indicate a high rate of inadequate treatment. Methods: A search of PubMed, Scopus, and Cochrane databases was conducted, focusing on primary research and meta-analyses. Data were categorized based on core concepts, and a narrative synthesis was performed. Results: The search identified a total of 1016 publications. After evaluating 203 full texts and additional sources from the grey literature, 80 studies were included in the review. The answers obtained were: (1) Preventive treatment does not decrease the incidence of IPN or mortality. Given the risks of bacterial resistance and fungal infections, antibiotics should be reserved for highly suspected or confirmed IPN; (2) The diagnosis of IPN does not always require microbiological samples, as clinical suspicion or computed tomography signs can suffice. Early diagnosis and treatment may be improved by using biomarkers such as procalcitonin and novel microbiological methods; (3) When indicated, early initiation of antibiotics is a key determinant in reducing mortality associated with IPN; (4) Antibiotics with good penetration into pancreatic tissue covering Gram-negative and Gram-positive bacteria should be used. Routine antifungal therapy is not recommended; (5) The step-up approach, including antibiotics, is the standard for IPN management; (6) Antibiotic duration should be kept to a minimum and should be based on the quality of source control and patient condition. Conclusions: Early antibiotic therapy is essential for the treatment of IPN, but prophylactic antibiotics are not recommended in AP. High-quality randomized controlled trials are required to better understand the role of antibiotics and antifungals in AP management.
Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
Authors: Birch Graham , Meniri Magali , Mitchell Chris , Mwanguhya Francis , Businge Robert , Ahabyona Solomon , Nichols Hazel J. , Cant Michael A. , Blount Jonathan D.
Published: September 2024

Reproductive activity is costly in terms of future reproduction and survival. Oxidative stress has been identified as a likely mechanism underlying this cost of reproduction. However, empirical studies have yielded the paradoxical observation that breeders often sustain lower levels of oxidative damage than non-breeders. The oxidative shielding hypothesis attempts to explain such data, and posits that breeders pre-emptively reduce levels of oxidative damage in order to protect their germ cells, and any resultant offspring, from harm caused by exposure to oxidative damage. While there is some empirical evidence of oxidative shielding in females, there have been no explicit tests of this hypothesis in males, despite evidence of the oxidative costs to the male reproductive effort and the vulnerability of sperm cells to oxidative damage. In this study, we assess lipid oxidative damage (malondialdehyde, MDA) in the ejaculates of reproducing and non-reproducing wild banded mongooses. We found that, among breeding males, ejaculate MDA levels were lower during mate competition compared to 2 months later, when individuals were not mating, which is consistent with the oxidative shielding hypothesis, and similar to findings in females. However, ejaculate MDA levels did not differ significantly between breeding and non-breeding individuals at the time of mating, contrary to expectation. The finding that ejaculate MDA was not higher in non-breeders may reflect individual differences in quality and hence oxidative stress. In particular, breeders were significantly older than non-breeders, which may obscure differences in oxidative damage due to reproductive investment. Further research is needed to establish the causal relationship between reproductive investment and oxidative damage in ejaculates, and the consequences for offspring development in banded mongooses and other species.