bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Microgrid Energy Demand Forecasting Using Convolutional Neural Networks
Authors: Karunarathne M. G. I. U. , Sudasinghe P. B. , Weeratunge H. Y. , Herath Damayanthi
Published: November 2024

Microgrids are localized energy systems that operate independently or in conjunction with the main power grid, integrating various energy sources for a reliable and resilient power supply. Microgrid energy demand refers to the electrical power required to meet consumer needs, influenced by factors such as time, weather, and habits of consumers. Accurate forecasting of energy demand is crucial for efficient microgrid operation, resource management, and optimization. Machine learning offers advantages over traditional methods in forecasting, such as the ability to handle complex relationships, adaptability to changes, and scalability. This paper proposes a Convolutional Neural Network (CNN) based approach to forecast microgrid energy demand. The study considers a dataset of multi-year power generation, consumption, and storage data in a microgrid and compares different approaches considering the metrics: Mean Squared Error, Mean Absolute Error, and R Squared Value. The results demonstrate that the CNN model performs well compared to other models. This study seeks to advance the application of machine learning in microgrid management.
Brain abscesses in an immunocompromised patient with a soft tissue mass
Authors: Mwase Thokozani , Mapiye Phineas , Mashigo Boitumelo , Le Roux Camilla , Lovelock Tamsin
Published: November 2024

Nocardiosis is a rare opportunistic infection and may be misdiagnosed as tuberculosis in the immunocompromised patient. This case report highlights the importance of doing tissue cultures in immunocompromised individuals to correctly identify Nocardia spp. and initiate appropriate treatment timeously.Contribution: This case report describes a typical case of disseminated nocardiosis with brain abscesses in an immunocompromised patient who would have typically been treated as disseminated tuberculosis.
Correction of Impacted Maxillary Permanent Anteriors - A Case Report
Authors: Sharma Varsha , Shukla Priti , Pattnaik Sushmita , Dutta Brahmananda
Published: November 2024

The maxillary anteriors play the most prominent role in an individual’s aesthetics, speech, and majorly psychology. The impaction of maxillary anterior teeth can be a challenging orthodontic problem that can be managed by interceptive orthodontics in early mixed dentition. In this particular case report, interceptive orthodontics alone may not bring desirable results because two problems need to be dealt simultaneously, namely, intraosseous crowding and midline shift due to impaction on the affected quadrant. In the article, a novel approach is being discussed, where aesthetics of the child was compromised due to impacted rotated maxillary anteriors that were exposed using soft tissue laser and allowed to erupt by selective removal of primary and permanent first premolar teeth on the affected side alone, leading to spontaneous alignment of arch discrepancy and relative correction of midline shift. A unilateral serial extraction sequence (D-4-C) would be effective treatment of choice. This approach adds psychological benefit to the child by using soft tissue lasers and unilateral serial extraction.
Relationship of Caries between Primary Molars and the Permanent First Molar - A Comparative Study
Authors: Almasri Youmna , Arhil Diala , Harfoush Abdulmalek , Barngkgei Imad
Published: November 2024

Context:

Dental caries is a multifactorial disease that affects large segment of population worldwide.

Aim:

To evaluate the detailed relationship between carious status of primary molars and permanent first molars among 8.5–10 years old children.

Methods and Materials:

Two-hundred and seven children were included in this cross-sectional study. The permanent incisors were fully erupted, the primary canines had no caries experience, and premolars were not erupted. The dentition status of the primary molars and permanent first molars was examined according to the World Health Organization criteria.

Statistical Analysis Used:

Pearson correlation, independent sample t-test, and linear and logistic regression analysis were used. The significance level was set at 0.05.

Results:

The mean (standard deviation) of decay, missing and filled teeth/surface for primary molars and permanent first molar (dmfs&dmft/DMFS&DMFT) were 4.12 (2.53), 8.40 (7.43), 0.77 (1.16) and 1.01 (1.81), respectively. Weak and medium correlations were found between d-component and D-component (r < 0.5), though statistically significant (P value < 0.001). Moreover, there was a relationship between the number of primary molars caries and the presence of caries on the permanent first molar located in the same side and jaw of these primary molars and those located in the opposite side and jaw of the primary molars.

Conclusion:

Nearly one-fifth of the caries on the permanent molars might be attributed to caries on the primary molars among 8.5–10 years-old children. The odds ratio of developing caries on the permanent first molars was 1.5 for children with primary molars caries in comparison to children with no primary caries.
Rehabilitation of Nonsyndromic Oligodontia in Deciduous Dentition Using Modified Hollywood Bridge - A Case Report
Authors: Safoora A K , Santhakumar Madhu , Vadakkepurayil Kannan
Published: November 2024

Oligodontia is a severe type of tooth agenesis involving six or more congenitally missing teeth, excluding the third molars. It is a rare condition and has a low prevalence in deciduous dentition. It can occur either as a part of syndromes or as a separate entity. This is a rare case report of a 3-year-old child with congenitally missing bilateral anterior and posterior deciduous teeth and its aesthetic and functional rehabilitation using a fixed appliance known as modified Hollywood bridge. In this appliance, molars are banded and acrylic teeth were secured to the stainless steel palatal wire with the help of heat cure acrylic resin. Modified Hollywood bridge provides a reasonable treatment option for the replacement of the missing deciduous teeth in children. It is more suitable for younger paediatric patients and also for physically or mentally handicapped patients.
Probiotic Supplementation for Periodontal Diseases - An Umbrella Review
Authors: Sharma Hunny , Ruikar Manisha , Verma Swati
Published: November 2024

Periodontal disease is a common condition caused by bacterial plaque that damages the supporting structures of teeth. Therefore, to manage periodontal disease, probiotic supplementation has emerged as a potential adjunct therapy. This umbrella review aims to summarize the primary findings, conclusions, and recommendations of systematic reviews and meta-analyses published on the effect of probiotics in treating periodontal disease. A systematic review of the literature was undertaken in four databases, i.e., MEDLINE, Embase, Cochrane Central, and Google Scholar using MeSH terms like ‘Probiotic*,’ ‘Prebiotic*,’ ‘Bifidobacterium,’ ‘Lactobacillus,’ and ‘Periodontitis,’ along with keywords like ‘synbiotic*,’ ‘Systematic review*,’ or Meta-analysis. The AMSTAR-2 tool was used to assess the quality of the included reviews once data were retrieved. A total of 22 systematic reviews and meta-analyses published in the last decade were reviewed, and probiotics were found to have potential benefits in reducing Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and gaining Clinical Attachment Level (CAL) in individuals with periodontal disease. However, there is mixed evidence on the effectiveness of probiotics in reducing gingival inflammation (GI) and dental plaque, and further research is needed to understand the mechanisms of action and potential health benefits of probiotics. The findings of this review suggest that probiotics as an adjunct treatment approach may have potential benefits for managing periodontal disease specially in terms of BOP, PPD, and CAL. However, they should not replace conventional treatments like scaling, root planing, and regular dental hygiene, which are essential for effective care.
Almost a Double Whammy! Acute Pulmonary Embolism and an Impending Paradoxical Embolism
Authors: Kumar Raj , Mehrotra Rahul
Published: November 2024

Pulmonary embolism (PE) is a relatively common cardiovascular disorder with high early mortality rates, despite advances in diagnosis and treatment. The risk of mortality is quite high in case the diagnosis is missed. High clinical suspicion is crucial in the diagnosis, more so in the young. Rarely, systemic embolism can occur in a patient with PE through a preexisting patent foramen ovale (PFO) (paradoxical embolism). Paradoxical embolism is associated with very high mortality rates. We report the case of a 31-year-old male, who was diagnosed with massive PE by echocardiography along with a thrombus-in-transit, trapped in a PFO, but without systemic embolization.
Revealing inducible clindamycin resistance in methicillin-resistant S aureus: A vital diagnostic imperative for effective treatment
Authors: Bawankar NS , Agrawal GN , Zodpey SS
Published: November 2024

Introduction:

The World Health Organization added methicillin-resistant S aureus (MRSA) to the list of “priority pathogens,” given its capacity to cause life-threatening infections. Clindamycin is a preferred treatment for non-complicated S aureus-induced skin and soft tissue infections. Its good tissue penetration and oral absorption make it suitable for outpatient therapy. However, the emergence of inducible and constitutive (MLSB) resistance led to clinical challenges, primarily due to the potential oversight of inducible resistance in routine antimicrobial sensitivity testing.

Materials and Methods:

This cross-sectional study was conducted at a tertiary care hospital during 2020–2022. A total of 158 MRSA isolates from various clinical specimens were analyzed. The Kirby-Bauer disk diffusion method using cefoxitin disk and D-test were used to identify MRSA and detect inducible clindamycin resistance (ICR), respectively.

Results:

Among the 158 MRSA isolates, 34.17% showed constitutive clindamycin resistance (MLSBc), while 22.15% displayed ICR (MLSBi). In addition, 10.13% of isolates demonstrated the MS phenotype, clindamycin, and erythromycin susceptibility, with 53 (33.54%) isolates susceptible to both antibiotics. The relative risk of clindamycin treatment failure was 7.66 times higher if the D-test was not used.

Conclusion:

To prevent clindamycin treatment failures, the D-test must be implemented to detect ICR in MRSA isolate. Neglecting simple and cost-effective tests may lead to inaccurate susceptibility reporting, jeopardizing treatment success.
Utility of interactive videogame in allaying preoperative anxiety in pediatric surgical patients - A randomized controlled study
Authors: Vinay AP , Karna ST , Ahmad Z , Waindeskar V , Ahmed R , Kuttan KA
Published: November 2024

Introduction:

Non-pharmacological distraction using video games (VG) is still under-explored in pediatric surgical patients.

Materials and Methods:

We conducted this randomized controlled study of 150 children, aged 4–12 years, scheduled for elective surgery in a tertiary care hospital to estimate the distractive effect of VG on immediate preoperative anxiety in children. In the intervention group (I), playing with VG was encouraged till anesthetic induction. The control group (C) received usual care with verbal reassurance. Modified Yale preoperative anxiety scale (mYPAS) score and presence of anxiety (mYPAS >30) were noted in the preoperative area (T1), at parental separation (T2), and anesthetic induction (T3). Parental separation anxiety score (PSAS) >3 was considered unacceptable parental separation. We used the Mann-Whitney test and t-test to find significance of intergroup mean difference of anxiety and logistic regression to find risk factors for immediate preoperative anxiety.

Results:

The mean m-YPAS (±SD) scores at T1 and T2 were 38 (±10.9) and 52.2 (±18.7) in group C and 46.5 (±13.5) and 33 (IQR: 28.3–65.5) in group I, respectively. The incidence of anxiety at T2 was higher in group C (81.3%) than in group I (59%). More children in group I (53/75) had acceptable separation than in group C (32/75) (P = 0.001). VG led to a 2.32 times lower risk of anxiety at T2 (P = 0.036). In children with acceptable separation, the incidence of anxiety was lower in group I (59%) than in group C (87%).

Conclusion:

VG-based distraction effectively reduced preoperative anxiety in children undergoing elective surgeries.
Counting homomorphisms from surface groups to finite groups
Authors: Klug Michael R.
Published: November 2024

We prove a result that relates the number of homomorphisms from the fundamental group of a compact nonorientable surface to a finite group G, where conjugacy classes of the boundary components of the surface must map to prescribed conjugacy classes in G, to a sum over values of irreducible characters of G weighted by Frobenius-Schur multipliers. The proof is structured so that the corresponding results for closed and possibly orientable surfaces, as well as some generalizations, are derived using the same methods. We then apply these results to the specific case of the symmetric group.
Epidemiological characteristics and risk factors of suspected and confirmed mpox cases during the 2022-2023 epidemic in the Capital Region, Korea
Authors: Shim Mingyeol , Cho Soo Hyeon , Lee Seung Eun , Kim Taeyoung
Published: November 2024

OBJECTIVES: This study investigated the general characteristics of laboratory-confirmed mpox patients in the Capital Region of Korea, as well as the risk factors for mpox infection, particularly focusing on the characteristics of polymerase chain reaction (PCR)-positive and PCR-negative cases.METHODS: We investigated 160 adults, excluding 4 minors, from 164 suspected mpox patients reported in Seoul, Gyeonggi, Incheon, and Gangwon from June 21, 2022 to October 31, 2023. Data were collected via telephone and face-to-face interviews. A statistical analysis of the general characteristics of the infection was conducted using frequency analysis and logistic regression.RESULTS: Of the 160 suspected cases of mpox, 59.3% (n=95) tested positive via mpox-PCR. Among the confirmed cases, 97.9% (n=93) were male. PCR-positive patients typically presented with genital and anal skin rashes or mucosal lesions, accompanied by pain. Additionally, 35.5% (n=33) of the male patients had human immunodeficiency virus (HIV) infections. Most confirmed cases (94.7%, 90/95) were believed to have contracted mpox through sexual contact during the maximal incubation period of 21 days prior to symptom onset, with a significant number reporting same-sex or casual contact. The most commonly collected and highest-yielding specimens from PCR-positive patients were from skin or mucosal lesions, whereas blood samples demonstrated the lowest percent positivity.CONCLUSIONS: In the Capital Region, most PCR-positive cases were male patients in their 30s who had sexual contacts and exhibited symptoms, aligning with findings from previous studies. These results provide a foundation for the differential diagnosis concerning mpox infection and the selection of PCR-test samples in clinical settings.
Miscarriage, stillbirth, and mortality risk from stroke in women: findings from the PLCO study
Authors: Tang Hui , Li Zhou , Zhang Yuan , Dai Mingjun , Wang Xiaoya , Shao Chuan
Published: November 2024

OBJECTIVES: Existing evidence suggests that miscarriage and stillbirth are associated with an increased risk of stroke in women. However, the impact of these events on stroke mortality remains unclear. This study aimed to elucidate the potential association between miscarriage and stillbirth and stroke mortality in women.METHODS: We employed a competing risk model using data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial to assess the relationship between miscarriage/stillbirth and stroke death. Death from other causes was considered as a competing risk, and we conducted a subgroup analysis to explore the potential impact.RESULTS: Our study included 68,629 women for miscarriage and 65,343 women for stillbirth. No significant association was observed between miscarriage and stroke mortality (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.84 to 1.10; p=0.58). While a single stillbirth did not show a significant association (HR, 0.81; 95% CI, 0.57 to 1.15; p=0.23), recurrent stillbirth (≥2) was associated with a significantly increased risk of stroke mortality compared to women with no stillbirths (HR, 2.24; 95% CI, 1.45 to 3.46; p<0.001).CONCLUSIONS: Our findings suggest that recurrent stillbirth, but not single events, is associated with an elevated risk of stroke mortality in women. Further research is warranted to clarify the underlying mechanisms and potential long-term health implications of recurrent pregnancy loss.
О подгруппах аффинной группы кольца Галуа четной характеристики
Authors: Bayramgulov Alik Vadimovich , Pogorelov Boris Aleksandrovich
Published: November 2024

Существуют четыре неабелевы 2-группы, содержащие циклическую группу индекса 2: группа диэдра, модулярная максимально-циклическая, квазидиэдральная, обобщенная группа кватернионов. Первые три группы содержатся в аффинной группе кольца вычетов $\operatorname{Aff} (\mathbb{Z}_{2^n}) $ и порождаются аддитивной группой и одной из трех инволюций мультипликативной группы кольца. Группа кватернионов в аффинной группе не содержится. В случае совместного использования этих групп возникает вопрос о существовании кольца, в аффинную группу которого вкладываются все четыре группы. Естественным кандидатом на такое кольцо является кольцо Галуа, обобщающее кольцо вычетов и поле Галуа. Описаны все подгруппы аффинной группы кольца Галуа порядка $2^{2n}$ и характеристики $2^n$, порожденные элементом аддитивного порядка $2^n$ и элементом порядка $2$ из мультипликативной группы. Список таких групп исчерпывается упомянутыми группами, за исключением обобщенной группы кватернионов, а также группами $ZD_{2^{n+2}}$ и $ZM_{2^{n+2}}$. Описаны все изоморфные вложения обобщенной группы кватернионов $Q_{2^{n+1}}$ в аффинную группу кольца Галуа $\operatorname{Aff}(\operatorname{GR}(2^{2n}, 2^n))$.
Global trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis
Authors: Zhang Fang-Shuo , Li Hai-Jing , Yu Xue , Song Yi-Ping , Ren Yan-Feng , Qian Xuan-Zhu , Liu Jia-Li , Li Wen-Xun , Huang Yi-Ran , Gao Kuo
Published: November 2024

BACKGROUND

Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM. Despite a significant increase in our understanding of youth-onset T2DM over the past two decades, the related review and evidence-based content remain limited.

AIM

To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research themes.

METHODS

This study utilized the terms “children”, “adolescents”, and “type 2 diabetes”, retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection (SCI, SSCI, ESCI). Utilizing CiteSpace and VoSviewer software, we analyze and visually represent the annual output of literature, countries involved, and participating institutions. This allows us to predict trends in this research field. Our analysis encompasses co-cited authors, journal overlays, citation overlays, time-zone views, keyword analysis, and reference analysis, etc.

RESULTS

A total of 9210 articles were included, and the annual publication volume in this field showed a steady growth trend. The United States had the highest number of publications and the highest H-index. The United States also had the most research institutions and the strongest research capacity. The global hot journals were primarily diabetes professional journals but also included journals related to nutrition, endocrinology, and metabolism. Keyword analysis showed that research related to endothelial dysfunction, exposure risk, cardiac metabolic risk, changes in gut microbiota, the impact on comorbidities and outcomes, etc., were emerging keywords. They have maintained their popularity in this field, suggesting that these areas have garnered significant research interest in recent years.

CONCLUSION

Pediatric and adolescent T2DM is increasingly drawing global attention, with genes, behaviors, environmental factors, and multisystemic interventions potentially emerging as future research hot spots.
Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes
Authors: Wang Ji-Kui , Zhang Di , Wang Jin-Feng , Lu Wan-Lin , Wang Jing-Yuan , Liang Shi-Feng , Liu Ran , Jiang Jing-Xin , Li Hong-Tao , Yang Xuan
Published: November 2024

BACKGROUND

At present, the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent, to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes, the report is as follows.

AIM

To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus (T2DM).

METHODS

We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral anastomosis. Metabolic indicators were collected preoperatively, as well as at 3 and 6 months postoperative. The metabolic indicators analyzed included body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), 2-hour blood glucose (PBG), glycated hemoglobin (HbA1c), fasting C-peptide, 2-hour C-peptide (PCP), fasting insulin (Fins), 2-hour insulin (Pins), insulin resistance index (HOMA-IR), β Cellular function index (HOMA-β), alanine aminotransferase, aspartate aminotransferase, serum total cholesterol (TC), low-density lipoprotein cholesterol (L DL-C), triglycerides (TG), high-density lipoprotein, and uric acid (UA) levels.

RESULTS

SBP, DBP, PBG, HbA1c, LDL-C, and TG were all significantly lower 3 months postoperative vs preoperative values; body weight, BMI, SBP, DBP, FBG, PBG, HbA1c, TC, TG, UA, and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months; and PCP, Fins, Pins, and HOMA-β were all significantly higher 6 months postoperative vs at 3 months (all P < 0.05).

CONCLUSION

Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.
Intestinal glucagon-like peptide-1: A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus
Authors: Liu Le-Rong , Luo Yuan-Yuan , Su Pei-Zhu , Zhang Cong , Li Zhao-Tao
Published: November 2024

In this article, we review the study by Jin et al , which examined the role of intestinal glucagon-like peptide-1 (GLP-1) in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus (T1DM). With the global rise of T1DM, there is an increased burden on society and healthcare systems. Due to insulin therapy and islet dysfunction, T1DM patients are highly vulnerable to severe hypoglycemia, a leading cause of mortality. In healthy individuals, counterregulatory mechanisms restore blood glucose during hypoglycemia, but repeated episodes impair these responses. Jin et al demonstrated that overexpression of GLP-1 attenuates the sympathetic-adrenal reflex and disrupts the secretion of counterregulatory hormones such as glucagon during hypoglycemia, leading to counterregulatory dysfunction. These findings highlight the critical role of GLP-1 in the impaired counterregulatory response to hypoglycemia in T1DM patients and provide new insights into the potential application of GLP-1-related therapies in T1DM patients.
Role of macrophage polarization in diabetic foot ulcer healing: A bibliometric study
Authors: Zhang You-Wen , Sun Lei , Wang Yan-Nan , Zhan Shi-Yu
Published: November 2024

BACKGROUND

Diabetic foot ulcers (DFUs) are a significant contributor to disability and mortality in diabetic patients. Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing. However, the complex mechanism, the difficulty in clinical translation, and the large heterogeneity present significant challenges. Hence, this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU healing.

AIM

To examine the relevant literature on macrophage polarization in DFU healing.

METHODS

A bibliometric analysis was conducted using the Web of Science database. Relevant literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software (VOSviewer and CiteSpace) and bibliometric online platforms. The obtained literature was then subjected to visualization and analysis of different countries/regions, institutions, journals, authors, and keywords to reveal the research’s major trends and focus.

RESULTS

The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023, especially in the latter period. Chinese researchers were the most prolific in this field, with 217 publications, while American researchers had been engaged in this field for a longer period. Qian Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this field. Shanghai Jiao Tong University was the institution with the most publications (27). The keywords “bone marrow”, “adjustment, replacement, response, tissue repair”, and “activation, repair, differentiation” appeared more frequently. The study of macrophage polarization in DFU healing focused on the regulatory mechanism, gene expression, and other aspects.

CONCLUSION

This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polarization in DFU healing from 2013 to 2023 in the Web of Science Core Collection database. The key hotspots in this field mainly include the regulation of macrophage activation, gene expression, wound tissue repair, and new wound materials. This study provides references for future research directions.
Facile synthesis of thiophene-embedded Baicalein via oxidative cyclization and anticancer activity against ovarian cancer cells via inhibiting PI3K/MTOR signaling pathway: in-vitro and in-silico study
Authors: Liu Zheqi , Zeng Lin , Wu Linshan , Song Daping , Chen Yanhua
Published: November 2024

This study illustrated the synthesis of a thiophene-embedded Baicalein (BAC) conjugate through the formation of a chalcone backbone, accomplished by refluxing hydroxyl-acetophenone with 5-nitrothiophene-2-carbaldehyde in the presence of piperidine. The BAC conjugate (5,6,7-trihydroxy-2-(5-nitrothiophen-2-yl)-4H-chromen-4-one) was obtained through the oxidative cyclization of the previously synthesized chalcone using DMSO/I2. The structure of BAC was determined by FTIR, 1H-NMR, 13C-NMR, mass spectrometry, and elemental analysis. The impact of BAC on SKOV-3 ovarian cancer cells was assessed via several pharmacological assays, including viability, apoptosis, migration, invasion, and cell cycle analysis. RT-qPCR analysis was performed to assess the impact of BAC on the mRNA levels of Bcl2, Bax, PI3K, Akt, and mTOR. BAC underwent docking analysis utilizing the 3D crystal structure of PI3K. The results indicate that BAC decreases cell viability, migration, invasion, and induces cell cycle arrest at the G2/M phase in SKOV-3 cells in a concentration-dependent manner. The Annexin FITC assay demonstrated the activation of apoptosis by increasing Bax expression and decreasing Bcl2 expression. The mRNA expression of PI3K, Akt, and mTOR was considerably suppressed relative to the untreated control, potentially through interactions with Trp201, Gln291, Leu657, Arg690, Phe694, and Arg849 of PI3K.
Keyword: Cell-viability, Apoptosis, Migration, Cell-cycle, RT-qPCR, Docking
Bull. Chem. Soc. Ethiop. 2025, 39(2), 367-379.                                                             
DOI: https://dx.doi.org/10.4314/bcse.v39i2.14
Synthesis of some novel dipeptides and their copper(II) complexes of (dibenzo [b, d] furan-2-ylsulfonyl) phenylalanine
Authors: O. Moustafa Gaber , A. Almehizia Abdulrahman , M. Naglah Ahmed , A. Zen Amer
Published: November 2024

A new series of dipeptide candidates (6-11) and corresponding octahedral copper complexes (12-15) were prepared by the synthesis of dibenzofuran-2-sulfonyl chloride (3). Then, the acid chloride (3) was coupled, at low temperature, with DL-phenylalanine using triethylamine and gave the corresponding acid (4) as starting material, which was converted to dibenzofuran-2-sulphonyl-DL-phenylalanyl chloride (5) using thionyl chloride. The latter acid chloride (5) was coupled with some aliphatic amino acids and gave the corresponding dibenzofuran-2-sulphonyldipeptide candidates (6, 7). Moreover, dibenzofuran-2-sulphonyldipeptide methyl ester derivatives (8, 9) were prepared via the esterification of the corresponding candidates (6, 7) and hydrazinolysis with hydrazine hydrate 99% of methyl esters (8, 9) to give the corresponding peptide hydrazides (10, 11). Then, all the newly prepared peptide derivatives (6-11) were reacted with copper acetate to afford the corresponding copper complexes (12-15). The newly synthesized compounds (6-15) were characterized.
KEY WORDS: Dibenzofuran-2-sulfonyl-DL-phenylalanyl chloride, Amino acids, Linear dipeptides, Copper complexes.
Bull. Chem. Soc. Ethiop. 2025, 39(2), 301-311.                                                              
DOI: https://dx.doi.org/10.4314/bcse.v39i2.9
The relationship between kidney function and peripheral artery diseases in patients with metabolic syndrome in a resource limited setup: a retrospective record review
Authors: Bouragba Imane , Diaf Mustapha
Published: November 2024

Background: Metabolic syndrome (MetS) is characterized by a cluster of cardiovascular risk factors and has an impact on the prevalence of chronic kidney diseases (CKD). We aimed to investigate the association between CKD and peripheral arterial diseases (PAD) in MetS patients.Patients and Methods: This retrospective record review was performed among patients with and without MetS over seven months. MetS was defined according to NCEP ATPIII criteria, PAD was diagnosed by an anklebrachial index (ABI) <0.9 and confirmed by angiography. Subjects were categorized on the basis of estimated Glomerular filtration rate (eGFR). The ANOVA test was applied to compare the three classes of eGFR. Boxplots were used to compare kidney biological parameters between males and females, MetS abnormalities and association of PAD with CKD.Results: From 342 patients, 56.40% were females, 77.8% with MetS, and 17.3% with PAD, 79.9% diabetics, 50.9% hypertensives, and 37.1% with dyslipidemia. The mean age was 61.56±17.30 years. Significant differences (p<0.05) were highlighted for age, anthropometric characteristics, diabetes, dyslipidemia, hypertension, PAD, family history and biochemical parameters. High levels of uric acid, albuminemia, micro-albuminuria and caliciumia in MetS patients were observed in both genders. These parameters increased with number of MetS components. CRP levels and lipid profile were significantly higher (p<0.05) in CKD patients. The prevalence of PAD in patients without CKD was 10.16% vs. 47.45 % in subjects with CKD.Conclusion: The coexistence of CKD and PAD was associated with MetS abnormalities and an inflammatory state, suggesting that the control of metabolic disorders may form part of the preventive measures for PAD and CKD.
La traite négrière transatlantique du 15ème au 19ème siècle
Authors: Atul Yasser Arafat , Atul Nyota Marie-Jeanne , Muya wa Muya Naomie
Published: November 2024

La traite négrière, comme phénomène social, n’était pas apparue au hasard. Elle n’est pas non plus la continuation de l’esclavage, comme pratique ancienne dans les sociétés africaines, et revêtant un caractère social, mais plutôt de l’esclavage mué en activité mercantiliste. La traite négrière avait été tributaire des conséquences fâcheuses sur l’économie, le social, la culture et la démographie de l’Afrique. Ce commerce juteux avait eu comme corollaire la chosification, l’instrumentation et la déshumanisation des Africains, utilisés dans les plantations de l’Amérique pour faire asseoir l’économie des Occidentaux, dont les actions perverses se poursuivent jusqu’alors par leurs multinationales disséminées en terre africaine.
Abstract
The slave trade, as a social phenomenon, did not appear by chance. Nor is it a continuation of slavery as an ancient practice in African societies, and of a social character, but rather slavery transformed into mercantilist activity. The slave trade had been affected by the adverse economic, social, cultural, and demographic consequences of Africa. This lucrative trade had as a corollary the objectification, instrumentation, and dehumanization of Africans, used on the plantations of America to establish the economy of Westerners, whose perverse actions have continued until now by their multinationals scattered on African soil.
Effects of Brachiaria decumbens leaf meal supplementation on the health, blood biomarkers, and relative telomere length of broiler chickens raised in tropical environments
Authors: Kassim N.A. , Chung E.L.T. , Alghirani M.M. , Ong Y.L. , Kamalludin M.H. , Abdullah Jesse F.F. , Loh T.C.
Published: November 2024

The main goal of this investigation was to determine the effects of Brachiaria decumbens leaf meal on the health performance, blood biomarkers, and relative telomere length of broiler chickens raised in tropical conditions. A total of 300, day-old, male, Ross 308 broilers were divided into six groups and given various feeding regimens based on a completely randomized design model. T1 commercial feed was devoid of antibiotics (negative control) whereas T2 commercial feed was supplemented with 100 mg/kg oxytetracycline (positive control). Commercial diets supplemented with 25, 50, 75, and 100 mg/kg of powdered B. decumbens leaf meal was given to the birds in treatments T3, T4, T5, and T6, respectively. Throughout the 42-day study, there were a few occurrences of leg problems, diarrhoea, and fatalities, but no statistical association was detected. The growth performance, leucocyte profile, immunoglobulin and cytokine concentrations, and relative telomere length, however, differed substantially among treatments.T3 broilers fed with diets supplemented with 25 mg/kg of B. decumbens leaf meal exhibited the best growth performance (highest final body weight and body weight gain; lowest cumulative feed conversion ratio), leucocyte profiling (increased total white blood cell count, monocytes, and basophil count; decreased heterophil to lymphocyte ratio), immunoglobulins (up-regulated IgG, IgA, and IgM), cytokines (increased IL4 and IL7), and telomere length. In conclusion, B. decumbens leaf meal can be used instead of antibiotics to enhance the growth and health of broilers raised in hot, humid conditions.
O „warjatunci JMT” i Modrzejewskiej
Authors: Kowalska Agnieszka
Published: November 2024

The content of the article are the memoirs and correspondence of the actress and traveller Jadwiga Mrozowska-Toeplitz, in which she described her reflections on the fellow artist Helena Modrzejewska. Both ladies met in Kraków in 1903, during Madame’s last performances. Mrozowska, in a colourful way, described both the American star’s acting and her attitude towards her theatre colleagues. The letters and published diaries interestingly show how Mrozowska’s attitude towards herself and Modrzejewska changed. They also indirectly touch on relations within and outside the theatre, as well as the social status of actors. Their content is certainly an interesting supplement to research on the history of theatre and the biographies of the artists themselves.
Warszawski hołd Madame 1909
Authors: Krasiński Edward , Samborska Joanna
Published: November 2024

Helena Modrzejewska (1840–1909) was a luminary of the stage, captivating audiences in Cracow (1865–1869) and Warsaw (1869–1876). Yet, her brilliance transcended national borders. From 1877 she soared to the zenith of American theatre history, her talent resonating across the globe. In 1880–1882 and 1885, she graced the stages of London and around Great Britain. Following Helena Modrzejewska’s passing on 8 April 1909 on Bay Island in Newport Beach, California, many articles, biographical entries, memories, and press notes flooded the Warsaw newspapers. Correspondents meticulously detailed funeral ceremonies in Los Angeles and Chicago. On 30 June, Modrzejewska’s body was transported to New York; then, on 3 July, to Europe on the Augusta Victoria steamer and later on to her hometown, Cracow. This comprehensive overview of Warsaw’s posthumous reception includes pivotal texts by exceptional artists (Józef Kotarbiński) and critics (Władysław Bogusławski), as well as a review of funeral ceremony descriptions, publications of correspondence excerpts, memoirs, and photo collections.
Stulecie urodzin Heleny Modrzejewskiej w cieniu wojny
Authors: Szydłowska Mariola
Published: November 2024

The subject of the article is the celebration of the hundredth anniversary of Helena Modjeska’s birth in 1940, which took place outside Poland due to the war situation. The outstanding artist was celebrated in the United States with two jubilee academies. The first one, organized on the initiative of the Polish Americans, took place on May 5, 1940 at the Polish Home in Los Angeles, and the second one was on October 27 in the Modjeska Club in New York. In a specific historical and geopolitical situation, both celebrations not only recalled and emphasized the achievements of this outstanding Polish-American artist, but were also a kind of national manifestation. The organizers wanted the American community to be interested in the current situation in Poland. The Academy in Los Angeles, during which Ignacy Paderewski’s message to American friends was replayed, even became a war appeal, a voice of support for Modjeska’s home country occupied by two invaders.
Zarządzanie wizerunkiem i strategie komunikacyjne Teatru 13 Rzędów Jerzego Grotowskiego – rekonesans
Authors: Kosiński Dariusz
Published: November 2024

The article proposes a very preliminary reconnaissance of the strategies and methods used and developed by the world-renowned Polish artist and theatre researcher Jerzy Grotowski (1933–1999) to create and manage a socially attractive image of himself and of the institution he run. It presents several basic ways and strategies of creating and managing these images developed in the Opole period of Grotowski’s activity (1959–1965), including Ludwik Flaszen’s comments and the ways in which the Theatre’s own publications, photography, radio and film are used as tools for creating and communicating the image.
Musicale i komedie muzyczne w latach dyrekcji Witolda Mazurkiewicza w Teatrze Polskim w Bielsku-Białej (2013–2023)
Authors: Linert Andrzej
Published: November 2024

The author described the dominant trend of musical shows in the repertoire of the Polish Theatre in Bielsko-Biała during the years of Witold Mazurkiewicz’s management. Three musicals and several comedies staged between 2013 and 2023 were analyzed. These included Zorba by Joseph Stein, Fred Ebb and John Kander directed by Mazurkiewicz, Sześć wcieleń Jana Piszczyka by Jerzy Stefan Stawiński adapted and directed by Wojciech Kościelniak and Człowiek z La Manchy by Dale Wasserman with music by Mitch Leigh directed by Mazurkiewicz. For the first time, the presence of musicals in a regional theatre was both an attempt to meet the expectations of the surroundings and the result of casting possibilities. Mazurkiewicz has proven that with creative, well-sung actors and a large group of collaborating artists, it is possible to come up with new and original stage solutions. Difficult musicals can also be produced to a high standard by small theatres where the musical repertoire functions on a par with the dramatic one.
O potrzebie polityki teatralnej i barierach rozwoju teatru w Polsce
Authors: Szulborska-Łukaszewicz Joanna
Published: November 2024

The article is concerned with the system of organising theatre life in Poland and the most important problems of the community, organizations and institutions within the theatre sphere. Such problems result from, among others, the current formal and legal regulations in Poland. In context of the voices appearing increasingly more often within the public debate that demand a special theatre law and formulation of a theatre policy at the central level, while also referring to the branch debate that took place in March 2024 at the Jan Kochanowski Theatre in Opole, the author wonders what determines the theatre’s success. Whether theatre policy at the central level is really necessary? Will the Act on Theatres solve the problems? Can the Act on Theatre be a solution to the problems, and if so, which ones?
Od dworca „pod słońce”. Transgranicznym szlakiem cieszyńskiego tramwaju
Authors: Pindór Mirosława
Published: November 2024

The present paper aims at describing one of the important symbols of the Cieszyn and Český Cieszyn – a tram line, a cultural heritage around which the history of both border towns can be written. The history of the Cieszyn tram line in the years 1911–1921 was depicted in the first part. The second part presents its current state and various ways of commemorating the tram line (which were undertaken after 2004), such as a joint bilingual theatre project of the Polish Stage and the Czech Stage of the Tĕšínské Divadlo (Cieszyn Theatre) in Český Cieszyn. The project is entitled Těšínské niebo Cieszyńskie nebe (Cieszyn Sky). There is another cross-border project entitled “Tramwaj Cieszyński wrócił! Těšínská tramvaj se vrátila!” (The Cieszyn tram is back) and many other valuable and diverse initiatives. The third part of this article describes two big cross-border projects: 1) “An analysis of the possibility to restore the tram line as a tourist attraction in Cieszyn and Czech Cieszyn”; 2) “On the trail of Cieszyn tram line – development of the cross-border tourism”. A number of activities undertaken and implemented in the second project were specified. The subject of the longer description was the greatest tourist attraction on the reconstructed famous tram route – a faithful replica of the Cieszyn Ringhoffer. The summary underlines that both the history of the Cieszyn tram line and the process of its commemoration and restoration depended on the political and social events, which have been of international importance. It was also emphasized that the symbolism of the Cieszyn tram line has changed over the years – from a symbol of the Cieszyn and Czech Cieszyn unification and integration of the societies inhabiting them, to “a core metaphor of one city as it was before 1920”.
Nagroda? Kulturowo-zarządcze dylematy zapisane w polskiej literaturze dokumentu osobistego XX wieku
Authors: Sieroń Dorota
Published: November 2024

This article analyses the socio-emotional context of the award as a tool for motivating the individual, which at the same time influences the environmental relations. The author made a historical reconstruction based on an analysis of personal documentary literature by referring to Jarosław Iwaszkiewicz’s jubilee award, and the Nobel Prize in Literature awarded to three Polish writers: two women – Wisława Szymborska and Olga Tokarczuk – and one man: Czesław Miłosz. The author’s findings and conclusions are related to the research hypotheses of Daniel H. Pinek.
Culture Management Must Fuel Socioenvironmental Change
Authors: Pałasz Michał
Published: November 2024

In the face of the unprecedented socio-environmental challenges of the Anthropocene, characterized by the interconnected crises of climate change, biodiversity loss, inequality, and more, the traditional approaches to culture management must evolve. Beginning with an analysis of the current state of polycrisis – including ecological boundaries breached and social inequalities exacerbated – this paper emphasizes the systemic nature of these challenges and argues for a redefinition of culture management that integrates both cultural and natural systems. It critiques the conventional understanding of culture management as limited to the administration of cultural institutions, advocating instead for a broader perspective that acknowledges culture’s integral role in shaping human-environment interactions. Drawing upon a variety of interpretations of culture, ranging from its broad anthropological functional conception as humanity’s adaptive mechanism to specific manifestations such as national, ethnic, religious, or organizational cultures, alongside sector-specific perspectives focusing on both cultural institutions and grassroots initiatives, as well as individual involvement in cultural practices, this paper argues for a paradigmatic shift towards nature-culture management. The purpose of this is to align human – and therefore cultural – activities with the environment on a global and local scale. An illustrative modelling exercise showcases the shift from traditional cultural management within a stable world towards a more conscientious and impactful approach that responds to the demands of the polycrisis, drawing upon the principles of Kate Raworth’s doughnut economics. The proposed “bucket wheel” model of culture management, which focuses on the value mining for sustainable well-being, highlights the circulation of values that promote positive social and environmental outcomes. This paper concludes by highlighting the pressing need to embrace this paradigm shift in culture management to effectively address the challenges of the Anthropocene. This finding underscores the necessity for cultural interventions that transcend existing paradigms, emphasizing the potential of culture management to drive socio-environmental change and contribute towards a sustainable future for people and the planet.
Ars, ratio et sensibilitas
Authors: Laberschek Marcin
Published: November 2024

The subject matter of the article is in line with the humanistic perspective of management and deals with management as an area of knowledge, the teaching of management in academic centres, and management as a human activity. The aim is to find an answer to the question of whether there is still a place for humanistic management – that is – a management in which human values are at least as important as material ones, in a world in which measurable results count, in which goals determine the means of achieving them, and if so, what such management should be distinguished by. Following the idea contained in Emil Orzechowski’s paper Arte et Ratione, the author indicates that such management is possible, while at the same time broadening this concept with the element of sensitivity (sensibilitas), or more precisely, ethical sensitivity. After all, management without human sensitivity is a mere tool for making profits regardless of the cost.
W poszukiwaniu miary sukcesu kariery artystycznej
Authors: Plebańczyk Katarzyna
Published: November 2024

The concept of success is a subjective category, making it a challenging area for research. It was, therefore, intriguing to delve deeper into what artists themselves consider to be a success. This text has been crafted around this issue, presenting a qualitative review of the relevant literature. This includes shifts in responsibility for career management from organisations to individuals and the evolving job market for artists, where there is an increasing move away from traditional employment models towards self-management of careers. Research findings selected by the author have been presented, highlighting the diversity of approaches, challenges, and barriers to self-management as defined by the artists themselves.