bluuebunny/crossref_metadata_2025 huggingface dataset:
Rare presentation and retrograde diagnosis of total colonic aganglionosis in a female infant: a case report
Authors: Chakhunashvili Konstantine , Chakhunashvili Davit G. , Kvirkvelia Eka , Gozalishvili Eka
Published: April 2023

Background

Total colonic aganglionosis is an extremely rare variant of Hirschsprung’s disease, which is predominant in males and can be seen in 1:50,000 live births. The presented case not only depicts a rare case, but also unusual clinical, laboratory, and instrumental data.

Case presentation

A 2-day-old Caucasian female newborn was transferred to our hospital from maternity. The initial presentation was reverse peristalsis, abdominal distention, and inability to pass stool. Fever had started before the patient was transferred. Hirschsprung’s disease was suspected, and tests such as contrast enema and rectal suction biopsy were done. Before enterostomy, the management of the disease included fluid resuscitation, colonic irrigation, antibiotic administration, enteral feeding, and supportive therapy. During ileostomy operation, no transition zone was visualized and full-thickness biopsy samples were retrieved from the rectum and descending colon. After surgical intervention, status significantly improved—defervescence and weight gain most importantly improved.

Conclusion

It is well known that diagnosis of total colonic aganglionosis may be delayed for months or even years since the transition zone may not be visible and rectal suction biopsy, unlike full-thickness biopsy, is not always reliable. It might be more prudent not to be derailed because of negative radiography and rectal suction biopsy. Also, doctors should be more suspicious of the disease if signs and symptoms are starting to be consistent with Hirschsprung-associated enterocolitis, despite biopsy and radiology results.
Hemoperfusion techniques using Jafron HA330 cartridge combined with BBraun Dialog+ dialysis machine in patient with coronavirus disease 2019 pneumonia and septic shock: a case report
Authors: Hartomuljono Adrian , Sugiarto Adhrie , Jennefer
Published: April 2023

Background

The use of hemoperfusion for cytokine removal and inflammatory mediators is increasingly intense, especially in coronavirus disease 2019 patients who are already known to the general public for having cytokine storms. However, we have known about these cytokine storms for a long time in the critical care world. One of the modalities to remove cytokines is to use filtration and adsorption techniques with continuous renal replacement therapy. The use of continuous renal replacement therapy is usually constrained by its very high cost compared with standard care, especially in Indonesia, where health costs are covered by national health insurance. In this case, we use hemodialysis and hemoperfusion, using a dialysis machine, which is more cost-effective and easy to use.

Case presentation

We used the Jafron HA330 cartridge, modified for the BBraun Dialog+ dialysis machine. This case report presents an 84-year-old Asian man with septic shock due to pneumonia, congestive heart failure, and acute chronic kidney disease accompanied by fluid overload. After undergoing hemodialysis and hemoperfusion separately, there was a gradual and significant clinical improvement. Clinical indicators, including the vasopressor inotropic score and infection markers, should all be considered when deciding whether to begin hemodialysis and hemoperfusion.

Conclusion

In general, using hemoperfusion to treat septic shock patients can reduce the length of stay in the intensive care unit, and morbidity and mortality.
Calcium oxalate crystal-induced secretome derived from proximal tubular cells, not that from distal tubular cells, induces renal fibroblast activation
Authors: Noonin Chadanat , Itsaranawet Tanakorn , Thongboonkerd Visith
Published: April 2023

Background

Kidney stone disease (KSD) is commonly accompanied with renal fibrosis, characterized by accumulation and reorganization of extracellular matrix (ECM). During fibrogenesis, resident renal fibroblasts are activated to become myofibroblasts that actively produce ECM. However, such fibroblast–myofibroblast differentiation in KSD remained unclear. Our present study thus examined effects of secreted products (secretome) derived from proximal (HK-2) vs. distal (MDCK) renal tubular cells exposed to calcium oxalate monohydrate (COM) crystals on activation of renal fibroblasts (BHK-21).

Methods

HK-2 and MDCK cells were treated with 100 µg/ml COM crystals under serum-free condition for 16 h. In parallel, the cells maintained in serum-free medium without COM treatment served as the control. Secretome derived from culture supernatant of each sample was mixed (1:1) with fresh serum-free medium and then used for BHK-21 culture for another 24 h.

Results

Analyses revealed that COM-treated-HK-2 secretome significantly induced proliferation, caused morphological changes, increased spindle index, and upregulated fibroblast-activation markers (F-actin, α-SMA and fibronectin) in BHK-21 cells. However, COM-treated-MDCK secretome had no significant effects on these BHK-21 parameters. Moreover, level of transforming growth factor-β1 (TGF-β1), a profibrotic factor, significantly increased in the COM-treated-HK-2 secretome but not in the COM-treated-MDCK secretome.

Conclusions

These data indicate, for the first time, that proximal and distal tubular epithelial cells exposed to COM crystals send different messages to resident renal fibroblasts. Only the secretome derived from proximal tubular cells, not that from the distal cells, induces renal fibroblast activation after their exposure to COM crystals. Such differential effects are partly due to TGF-β1 secretion, which is induced by COM crystals only in proximal tubular cells.
Clinical application value of expanded carrier screening in the population of childbearing age
Authors: Fang Yuqin , Li Jingran , Zhang Miaomiao , Cheng Yuan , Wang Chaohong , Zhu Jiansheng
Published: April 2023

Objective

The objective of this study was to explore the clinical utility of the implementation of expanded carrier screening (ECS) in Chinese population of childbearing age.

Materials and methods

Based on capillary electrophoresis, a first-generation sequencing technology, a prospective screening study of carriers of 15 single-gene diseases was carried out in 327 subjects in Anhui Province, including 84 couples and 159 women of childbearing age, the disease carrier rate, types of screened pathogenic genes, and incidence of both partners carrying the same pathogenic genes were summarized and analyzed.

Results

In 320 people with normal phenotypes who underwent ECS for 15 genetic diseases and 7 spouses who underwent targeted gene sequencing, 65 carriers of at least one disease were detected, with a total carrier rate of 20.31% (65/320). Among the 65 carriers, 81.54% (53/65) carried one genetic variant, 16.92% (11/65) carried two genetic variants, and 1.54% (1/65) carried three genetic variants. In this study, the three diseases with the highest carrier rates were hereditary deafness (8.13%, 26/320), Wilson's disease (4.06%, 13/320), and phenylketonuria (3.13%, 10/320). One high-risk couple (1.19%, 1/84) was detected.

Conclusions

It has certain clinical application value to implement ECS in the population of childbearing age in China.
IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma
Authors: Kunhiraman Haritha , McSwain Leon , Shahab Shubin W. , Gershon Timothy R. , MacDonald Tobey J. , Kenney Anna Marie
Published: April 2023

Medulloblastoma (MB) is the most common pediatric brain malignancy and is divided into four molecularly distinct subgroups: WNT, Sonic Hedgehog (SHHp53mut and SHHp53wt), Group 3, and Group 4. Previous reports suggest that SHH MB features a unique tumor microenvironment compared with other MB groups. To better understand how SHH MB tumor cells interact with and potentially modify their microenvironment, we performed cytokine array analysis of culture media from freshly isolated MB patient tumor cells, spontaneous SHH MB mouse tumor cells and mouse and human MB cell lines. We found that the SHH MB cells produced elevated levels of IGFBP2 compared to non-SHH MBs. We confirmed these results using ELISA, western blotting, and immunofluorescence staining. IGFBP2 is a pleiotropic member of the IGFBP super-family with secreted and intracellular functions that can modulate tumor cell proliferation, metastasis, and drug resistance, but has been understudied in medulloblastoma. We found that IGFBP2 is required for SHH MB cell proliferation, colony formation, and cell migration, through promoting STAT3 activation and upregulation of epithelial to mesenchymal transition markers; indeed, ectopic STAT3 expression fully compensated for IGFBP2 knockdown in wound healing assays. Taken together, our findings reveal novel roles for IGFBP2 in SHH medulloblastoma growth and metastasis, which is associated with very poor prognosis, and they indicate an IGFBP2-STAT3 axis that could represent a novel therapeutic target in medulloblastoma.
Customer accounting practices, antecedents and performance implications: insights from the financial services industry in Kuwait
Authors: Ojra Jafar , Opute Abdullah Promise , Alsaqer Abdulaziz M.
Published: April 2023

Competing effectively in the contemporary marketing landscape is becoming increasing challenging. Equally increasing therefore is the pertinence for organisations to be customer oriented. Academic discourse emphasises the need for more customer-oriented approach. Inspired by gaps in the literature, this study explores the contingency factors and performance implications of customer accounting in the Kuwaiti financial services industry. A questionnaire was used to collect data, and data analysis was based on 115 responses from management accountants of participating firms. This study reports critical insights that enhance the no one-size fits all notion of contingency foundation. For organisations in the industrial and geographical setting covered in this study, the insights from this study offer relevant cues for optimising customer accounting operationalisation and maximising the organisational performance impact. The limitations of this study have been acknowledged and critical directions for further knowledge development flagged.
Case report - sulfonylurea poisoning mimicking vertebrobasilar acute ischemic stroke
Authors: Kędra Kamila , Michalik Izabela , Oleszko Michał , Wiącek Marcin
Published: April 2023

Background: We report the case of sulfonylurea induced hypoglycemia manifesting as acute encephalopathy with focal neurological signs misdiagnosed as posterior circulation acute ischemic stroke (AIS) and discuss the potential effects of hypoglycemia on central nervous system, as well as its differentiation from AIS. Case presentation: A 64-year-old patient with type II diabetes treated with glimepiride was transferred to the Department of Neurology after the procedure of radical prostatectomy. On admission, the patient was unconscious with four limb paresis and bilateral Babinski sign. Non-contrast head CT and CT angiography vessels did not reveal any abnormalities. Due to exceeded therapeutic window the patient was disqualified from intravenous thrombolysis. At the admission hypoglycemia was observed and promptly corrected with the 5% dextrose infusion. For the next 72 hours repeated intravenous glucose infusions were needed to maintain its levels above 70 mg/dl. Based on the absence of ischemic changes on MRI and repeated decreases in glucose level for the next 3 days, glimepiride induced hypoglycemic encephalopathy was diagnosed. Within 24 hours of admission the patient regained consciousness and eventually presented four-limb paresis as a result of prolonged neuroglycopenia. Conclusions: Prolonged insufficient brain nutrition can result in permanent or long-lasting brain damage, manifesting as impaired consciousness and focal neurological signs. Perioperative sulfonylureas intake may result in prolonged hypoglycemia.
Аmelioration by phytoadaptogene of effects of balneofactors of Truskavets’ Spa on patients with post-radiation encephalopathy
Authors: Fihura Oksana
Published: April 2023

Background. We have previously explored effects of Ukrainian phytocomposition “Balm Truskavets’” on parameters of neuro-endocrine-immune complex and biophotonics in humans with maladaptation. It is known that in patients with post-radiation encephalopathy the reaction to some stimuli is significantly changed, therefore it needs correction. The purpose of this study is to test the ability of this phytocomposition to amelioration the effects of standard balneotherapeutic complex in patients with post-radiation encephalopathy. Material and methods. The research was carried out through a retrospective analysis of the database of the Truskavetsian Scientific School of Balneology, which remained unpublished. The object of observation in 1997 were 19 men and 3 women with urate urolithiasis and chronic pyelonephritis who were exposed to pathogenic factors of the accident at the Chоrnobylian nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice: on admission and after two weeks of rehabilitation in sanatorium “Perlyna Prykarpattya” (Truskavets’ Spa). 11 patients received standard balneotherapy while the other 11 patients additionally received the phytocomposition “Balm Truskavets’”. According to the protocol, blood pressure, routine hematological and biochemical blood parameters were determined. In addition, physical working capacity (PWC150) as well as EEG, heart rate variability (HRV) and immunity parameters were determined. Results. Standard balneotherapy increases the decreased level of T-helper lymphocytes, but further decreases the level of B-lymphocytes, glomerular filtration rate and PWC150, in combination with increased normal levels of blood creatinine and urea, as well as decreased levels of diastolic BP and heart rate. This is accompanied by a further increase in the sympathetic tone and the leveling of the increased of ULF band HRV as marker of level in the plasma of catecholamines and glucocorticoids. Additional use of phytocomposition limits the adverse effects of standard balneotherapy by modulating EEG and HRV parameters. Conclusion. Phytocomposition "Balm Truskavets'" by modulating the parameters of the nervous system limits the adverse effects of standard balneotherapy at the Truskavets’ Spa in patients with post-radiation encephalopathy.
Multiple sclerosis: is there a role for coenzyme Q10?
Authors: Mantle David
Published: April 2023

Mitochondrial dysfunction, oxidative stress and inflammation have been implicated in the pathogenesis of multiple sclerosis (MS). Therefore, there is a rationale for the use of supplementary coenzyme Q10 (CoQ10) as a potential novel therapeutic agent for this disorder, based on the key roles of this vitamin-like substance in normal mitochondrial function, as an antioxidant and as an anti-inflammatory agent. In this article, the pre-clinical and clinical studies relating to the use of supplementary CoQ10 for the treatment of MS is reviewed.
Hyperbaric oxygen to save the brain
Authors: Palmer Sarah Jane
Published: April 2023

Hyperbaric oxygen (HBO) therapy, the administration of pure oxygen at a pressure greater than the pressure of atmospheric oxygen, is a promising treatment for a range of neurological conditions, including traumatic brain injuries, Alzheimer's disease and comatose states. The research exploring the use of HBO therapy for neurological conditions is extremily exciting, and in this article, Sarah Palmer presents some key studies, demonstrating their findings and highlighting just how promising this potential therapy is.
The use of acupuncture as a complementary treatment for people with neurological conditions
Authors: Huber Pia AJ
Published: April 2023

Acupuncture is the insertion of very fine needles at specific points of the body. Originally based in East Asia, acupuncture has been found to be highly beneficial to patients suffering from many diseases and research has found measurable physiological effects. Research evidence shows that acupuncture reduces the experience of pain, stress and anxiety. It also appears to improve digestive problems, helps fatigue, and benefits gait impairments and bladder dysfunction in people with multiple sclerosis.
Experiences implementing hydrocolloid dressings after caesarean section
Authors: Scheck Simon M , Sircar Sikhar
Published: April 2023

Aim:

Despite increasing interest in reduction of surgical site infection (SSI) after caesarean section, there is limited evidence around optimal dressing choice. We report the experience of a secondary hospital in regional New Zealand changing from a basic contact dressing to a hydrocolloid dressing over a three-month period, reporting SSI rates, midwifery and nursing experience, and cost.

Method:

A retrospective cohort study of hydrocolloid dressings for caesarean sections over three months, compared with basic contact dressings in caesarean sections in the same period one year previously. We report wound swabs with significant growth; results from a survey sent to midwifery and nursing staff; and cost per dressing, as well as the number of dressing changes before discharge.

Results:

In the hydrocolloid group (n=94) four patients had significant growth on wound swabs (4.3%, 95% confidence interval (CI): 0–10.6%) compared with six patients in the basic contact group (n=117) (5.1%, 95% CI: 1.0–7.1%). Only 9/20 (45%) midwives reported that they liked the hydrocolloid dressings, compared with 19/21 (90%) liking the basic contact dressings, primarily due to difficulty removing the dressings. When accounting for the number of dressing changes on the ward, the cost per caesarean section was $5.11 NZD for hydrocolloid dressings, compared with $5.72 NZD for basic contact dressings.

Conclusion:

Our initial experience with a change to hydrocolloid dressings showed promising results with regard to SSI rates, as well as a cost reduction. This, however, is to be balanced with dressings that are potentially more difficult to remove, resulting in reduced midwifery and nursing satisfaction.
Hyalomatrix coverage in scalp wounds with exposed cranium and dura
Authors: Kozusko Steven D , Bird Dorothy , Fahey A Leilani
Published: April 2023

Aim:

The armamentarium of options available for soft tissue reconstruction of the scalp spans the reconstructive ladder. The purpose of this paper is to describe a case series of patients with exposed cranium and dura who were successfully reconstructed using esterified hyalomatrix (eHAM, Hyalomatrix, Medline Industries Inc., US).

Methods:

After obtaining Institutional Review Board approval, a retrospective review of the senior author's (ALF) patient database was completed. Patients who underwent scalp reconstruction using eHAM were identified. Each patient's chart was reviewed and data collected on demographics, days to skin graft, duration of follow-up, pathology, comorbidities and complications.

Results:

This case series consisted of five patients aged ≥18 years, with scalp wounds exposing dura or cranium, who were treated with eHAM as a bridge to definitive coverage with a skin graft. Each wound successfully granulated the exposed critical structure with the use of the eHAM. The mean time to skin graft coverage was 41 days, with a range of 13–79 days. Of the series of five patients, four had a follow-up of ≥12 weeks. The mean defect size was 90.2cm2.

Conclusion:

Complex scalp reconstruction can be accomplished using healing by secondary intention, skin grafts, local flaps, tissue expansion and free tissue transfer. As shown in this case series, another option available in select patients is using a dermal substitute such as eHAM. This is one treatment option available to reconstructive surgeons in multiple specialties.
Efficacy of bioabsorbable dressing combined with antibacterial spray for treatment of third-degree burns
Authors: Ting Liu , Yongchao Li , Chan Liu , Yeda Lv , Dongxu Liu , Zhiming Yuan
Published: April 2023

Objective:

To evaluate the clinical efficacy of a bioabsorbable dressing in combination with antibacterial spray in treating third-degree burns.

Method:

Patients with third-degree burns in our hospital from February 2019 to February 2020 were enrolled and divided into an experimental group and a control group. In all patients, two wound repair surgeries were performed. During the first surgery, bioabsorbable dressing (PELNAC, Gunze Medical Equipment (Shenzhen) Co. Ltd., China) was used for wound treatment. During the second surgery, autologous split-thickness skin graft was performed. For patients in the experimental group, bioabsorbable dressings (PELNAC) were uniformly applied with antibacterial spray during the operation and during postoperative dressing. For patients in the control group, antibacterial spray was not used.

Results:

A total of 68 patients took part in the study (experimental group n=36; control group n=32). Infection rate in the experimental group was significantly lower than that in the control group (2.8% versus 21.9%, respectively; p<0.05). The mean wound healing time in the experimental group was shorter by 3.2 days and the wound healing rate of the experimental group was significantly higher than that in the control group (p<0.05). Vancouver Scar Scale (VSS) scores at specific postoperative time intervals were significantly reduced in the experimental group compared with those in the control group (p<0.05).

Conclusion:

Bioabsorbable dressing combined with antibacterial spray could reduce infection rate, shorten wound healing time and reduce scar formation in repairing third-degree burns.
Intralesional epidermal growth factor therapy in recalcitrant diabetic foot ulcers
Authors: Özker Emre
Published: April 2023

Objectives:

Diabetic foot ulcers (DFUs) cause high morbidity and mortality despite best treatment. Thus, new products are urgently needed to treat DFUs. Intralesional epidermal growth factor (EGF) (Heberprot-p) is considered to be an adjuvant therapy to standard of care (SOC) in DFUs. In the present study, the effect of Heberprot-p treatment on wound healing is compared to standard treatment.

Methods:

The data of patients with DFUs were retrospectively analysed. The patients who had had DFUs of at least four weeks' duration and who had been treated in the wound clinic between January 2014 and 2017 were included in the study. The patients were divided into study and control groups. The study group consisted of patients in whom intralesional recombinant human EGF, Heberprot-p 75μg, was applied; the control group consisted of the remaining patients in whom EGF was not applied. The efficacy of Heberprot-p treatment in Wagner 2 and 3 DFUs were retrospectively investigated.

Results:

The study group (n=29 patients) who received Heberprot-p treatment was found to have shorter treatment times and higher rates of wound healing than the control group (n=22 patients). Although the amputation rate in the study group was less than the control group, the difference was not statistically significant.

Conclusion:

Heberprot-p therapy is a promising treatment in DFUs, which can be routinely used as an adjunct to standard care.
Pressure injury susceptibility related to lifestyle factors in patients with spinal cord injury: a cross-sectional survey
Authors: Gyawali Dronacharya , Tharu Niraj Singh
Published: April 2023

Aim:

To identify the lifestyle factors preventing and predisposing to the development of pressure injuries (PIs) in individuals with spinal cord injury (SCI) living in the community in Bangladesh.

Methods:

A quantitative cross-sectional survey was conducted using a convenient sampling method. An equal number of participants, both with PIs and without, were recruited from the community, and a face-to-face interview was conducted. The standard outcome measure used to identify lifestyle factors in SCI was the Spinal Cord Injury Lifestyle Scale. The odds ratio (OR) was used to measure the associated difference between both groups and with sociodemographic variables. A p-value of ≤0.05 was considered statistically significant.

Results:

The study cohort comprised 80 participants—40 with PIs and 40 without. The study findings showed that lifestyle factors that were strongly associated with the occurrence of PIs (p<0.01, OR: <1) were: smoking; regular exercise; weight-bearing activity; body position on wheelchair; joint contracture; skin examination; pressure relief technique; wearing a protective device; accessibility; bladder and bowel management (p=0.03, OR: 0.32). Whereas, bladder incontinence appeared as a strong risk factor (p=0.04, OR: 2.5) for developing PIs in people with SCI.

Conclusion:

The outcome of this study suggests that people with SCI should be aware of, and review, their lifestyle factors to reduce their chance of developing PIs.
Antimicrobial photodynamic therapy: modern technology in the treatment of wound infections in patients with burns
Authors: Mahmoudi Hassan , Pourhajibagher Maryam , Chiniforush Nasim , Alikhani Mohammad Yousef , Bahador Abbas
Published: April 2023

Background:

Staphylococcus aureus is one of the most frequently isolated microorganisms from burn wounds. Antimicrobial photodynamic therapy (aPDT) is a new strategy that may improve antimicrobial treatment.

Method:

This study evaluated three meticillin-resistant Staphylococcus aureus (MRSA) and three meticillin-sensitive Staphylococcus aureus (MSSA) clinical isolates, which produced a biofilm with 0.1mg/ml Toluidine Blue O (TBO) (Sigma-Aldrich, Germany) with an energy density of 45J/cm2 and 90J/cm2, for MRSA and MSSA, respectively. The antibiofilm potential of aPDT with TBO was analysed using crystal violet assays and scanning electron microscopy.

Results:

TBO-aPDT significantly degraded the biofilm formed by MRSA and MSSA clinical isolates (p<0.05).

Conclusion:

Our results indicated that aPDT is an effective approach to combat bacterial biofilms associated with burn wound infection. aPDT could provide a supplemental to the treatment of wound and tissue infection, and patients with burns may benefit from combined treatments.
The role of surfactants and biosurfactants in the wound healing process: a review
Authors: Ohadi Mandana , Forootanfar Hamid , Dehghannoudeh Negar , Banat Ibrahim M , Dehghannoudeh Gholamreza
Published: April 2023

Wound healing refers to the complex process of restoring the forms and functions of damaged tissues. Multiple growth factors and released cytokines tightly regulate the wound site. Healing processes can be disrupted by any alteration that would aggravate the damage and lengthen the repair process. Some of the conditions that may impair wound healing include infections and inflammation. Surfactants are amphiphilic compounds widely used in various formulations including detergents, food, pharmaceuticals and cosmetics. Biosurfactants, therefore, are surface-active compounds produced by biological agents, particularly yeast or bacteria, and represent a safer and environmentally preferred alternative to chemical surfactants. Numerous studies have targeted surface-active molecules as wound healing agents for their anti-inflammatory, antioxidant and antibacterial potential. This review focuses on surface-active molecules used in wound healing activities and analyses their effectiveness and mechanisms of action.
The matrix inverse Young inequality
Authors: Drury Stephen
Published: April 2023

An inverse Young inequality is established for positive definite matrices.
Multi-Fragment Patellar Non-Union in a Young Patient Due to Failed Fixation and its Management – A Rare Case Report
Authors: Mahajan Neetin P , GS Prasanna Kumar , Kondewar Pranay , Jadhav Kishor
Published: April 2023

Introduction: Multi-fragmentary patellar non-union is rare and it causes functional disability in patients. The purpose of studying this case is to present an unusual patella multi-fragmentary non-union and discuss its management. Case presentation: We present a case of a 25-year-old male patient presented with pain and instability and decreased movements of the right knee since last 1 year. The patient had a history of trauma for which he was operated at the local hospital. X-ray and CT scan of the right knee was suggestive of the non-union of the right patella with three main fragments. We managed with open reduction and internal fixation using CC screw, cerclage and tension band wiring. At one-year follow up, the patient is having a clinical and radiological union of non-union with good functional outcome. Conclusion: Combination of cannulated cancellous screw, cerclage and tension band wiring provides stable fixation in the multi-fragmentary patellar non-union, helps in early mobilisation which in turn helps in getting good functional outcome and prevents implant-related complications. Keywords: Non-union; Multi-fragmentary patella; Internal fixation; Fixation failure.
Chronic Tibial Tunnel Infection Following ACL Reconstruction: A Case Report and Review of the Literature
Authors: Pokhare Bishnu , Kalawar Rosan Prasad Shah , Goyal Ashish Kumar
Published: April 2023

Introduction: Rupture of the anterior cruciate ligament (ACL) is a common injury in active people and one of the most common knee injuries in sports. Foreign body granuloma with concomitant infection is a rare complication in ACL surgery. Very few cases have been reported on it. We present a young patient with a chronic discharging sinus at a surgical site on the tibia in a diabetic patient and its successful management. Case Report: A thirty-two-year-old male presented to us with a persistent discharging sinus at the surgical site following an Anterior Cruciate Ligament (ACL) reconstruction two years back. Since then, he developed wound infection at the incision site created for graft harvesting, which kept on discharging sero-purulent discharge even with several antibiotics and local dressing courses. There was no stiffness or instability in the knee. We did a follow-up arthroscopic evaluation of the joint and debridement of the wound. A portion of hamstring graft and non-absorbable suture with unhealthy granulation tissues were found subcutaneously during the surgery. A partially resorbed bioscrew with unhealthy granulation tissue was observed in the tibial tunnel. After thorough debridement of the site, the wound completely healed. Conclusion: Surgical site infection and foreign body granuloma should be considered and treated accordingly if the patient presents with persistent discharging sinus at the surgical site in ACL reconstruction Keywords: Anterior cruciate ligament reconstruction, ACL, Surgical site infection, Tibial tunnel.
Comparison of Functional Outcome Between Trans– 2nd Metacarpal Fixation and Trans-Trapezius Fixation with K-Wire for Bennett Fracture
Authors: Navale Vishal V. , Gulati Manasee
Published: April 2023

Introduction: An articular fracture of the base of the thumb metacarpal consisting of a single, variable-sized, volar-ulnar fracture fragment is termed Bennett fracture. In the studies conducted so far there has been paucity in the knowledge about the methods of k wire fixation for the Bennett fracture and hence the purpose of this study is to compare functional outcome between the trans – 2nd metacarpal fixation and trans – trapezius fixation with K wire for Bennett fracture. Methods: Patients were 18 years and above with no previous injury on the 1st metacarpal . Final assessment was performed from six months to nine months after the treatment with the DASH Score, VAS scale for pain, Hand Grip strength by Dynamometer. Radiographic images were taken at 6 months post-op in two separate views to evaluate post-traumatic arthritis of the first CMC joint. Results: Statistical analysis showed a correlation between Pain and DASH score to be 0.946 in TTZ group and 0.966 in T2MC group and hence signifies that patients in T2MC group had a better functional outcome with lower DASH score and lower pain score. Significant correlation was seen between Pain and Grip strength, with -0.587 in TTZ group and -0.482 in T2MC group. Higher pain score correlated with higher DASH score and lower Grip strength and hence we can conclude that T2MC had a better functional outcome post-surgery than TTZ technique of fixation. Post op radiographs showed that T2MC group of patients had a better outcome with less arthritic complications and less pain and better grip strength. Conclusion: This study gives us the overview about the two fixation methods of Bennett fracture , and that when trans 2nd metacarpal fixation is done , there are less chances of arthritis of the CMC joint as well as better functional outcomes post operatively as compared to trans trapezial fixation and hence guides a surgeon to make a decision about the technique of fixation to be employed during fixing such fracture. Keywords: Bennett fracture, Trans-trapezial, Trans- 2nd metacarpal, Functional outcome
Radiological Assessment and Functional Outcomes of Hand and Wrist in Patients with Distal End Radius Fractures
Authors: Pethapara Yogesh , Singh Vishwajeet , Patel Ronak
Published: April 2023

Background: Fractures of distal end of radius are the most common fractures among the patients treated at emergency rooms. Despite a considerable progress in medical field over the last several years, distal end of radial fracture outcomes seem to be unsatisfactory in fairly large number of cases. The aim of this study was to determine the functional outcome of hand and wrist after distal end of radius fractures managed by different treatment modalities, to determine the complications of each methods used for treatment of distal end of radius fractures, to compare anatomical outcome with functional outcome after management of fracture distal end of radius. Methods: A clinical, observational, prospective type of study was carried out on 40 cases with fractures of distal end of radius. The fractures were classified according to AO classification. After initial evaluation patients were taken up for either conservative or operative treatment. All the cases were followed up and assessed for minimum of 6 months. Patients with complications were followed up more frequently. Results: Anatomical results were evaluated according to Sarmiento’s modification of Lindstrom Criteria. Clinical and functional results were evaluated according to demerit point system of Gartland and Werley with Sarmiento modification Conclusions: There is direct relationship between anatomical result and functional outcome. Therefore, every effort should be made to restore normal length and alignment, as well as articular surface congruency of distal radius. Keywords: Distal end of radius, Demerit point system of Gartland and Werley with Sarmiento modification, Sarmiento’s modification of Lindstrom Criteria, Functional evaluation
Sideswipe Injury to the Leg – A Hefty Price for an Autorickshaw Ride: A Case Report
Authors: Kasotya Devender , Bhatia Nishant , Yadav Rajeev , Sabat Dhananjay
Published: April 2023

Introduction: Sideswipe injury is often described as a complex elbow injury occurring when the elbow rests on a side bar of the window of a vehicle and is then impacted by another vehicle travelling in the same or opposite direction. Side swipe injury to the leg is uncommon. Although the term side swipe is mostly used for elbow injuries, we came across a case of open comminuted fibular fracture of right leg resulting from side swipe while travelling in a tricycle. Case Presentation: A 27-year-old male presented to us after sustaining an injury to his right leg while he was travelling in a tricycle with his right leg protruding out. There was an open wound of size 20 cm x 10 cm on lateral aspect of the middle one-third of his right leg and x-rays revealed a comminuted fracture of mid shaft of fibula. He was managed with debridement, vacuum assisted closure (VAC) dressing, split thickness skin grafting and plaster immobilization. At one year follow-up, the patient had excellent function in the leg with no activity limitation and just a minor loss of power in eversion. Conclusion: Sideswipe injury of the leg is an infrequently reported entity and can occur if the leg is protruding out while riding in a tricycle (autorickshaw). Keywords: Leg, Sideswipe injury, Tricycle related injury.
Adult Traumatic Eight Days Old Anterior Dislocation of the Hip with Ipsilateral Fracture Upper Third Shaft Femur: An Atypical Case Report
Authors: Sharma Brijesh , Sharma Yajuvendra Kumar , Yadav Rohit , Pal Chandra Prakash
Published: April 2023

Introduction: Anterior or posterior dislocation of hip are usually associated with fracture head of femur but dislocations associated with femoral neck, trochanter and shaft are very rare and among this anterior dislocation of hip with ipsilateral fracture of shaft femur is an extremely rare injury. We reported a case of anterior dislocation of hip associated with ipsilateral fracture shaft femur upper third in adult male. Case presentation: A 25 yrs male, low socioeconomic status was brought to our emergency department was conscious but unable to mobilize his right lower limb and external rotation deformity was present with some shortening. No neurovascular compromise and was found fracture shaft femur along with anterior dislocation of right hip on x-ray and treated by close reduction of femoral head and internal fixation of fracture shaft femur by intramedullary nail. Conclusion: Early diagnosis of hip dislocation is essential to prevent avascular necrosis of femur head in future. We concluded that there is no need of open reduction for anterior hip dislocation in every such case. Close reduction of anterior dislocation of hip followed by femur interlocking for femoral shaft fracture is good option for management for such type of injuries. Keywords: Hip dislocation, Close reduction, Avascular necrosis, Fracture dislocation
Management of Pauwels Type 3 Femur Neck Fracture by Open Reduction Internal Fixation with DHS System and Intertrochanteric Valgus Osteotomy: A Case Series
Authors: Mahajan Neetin P. , Kondewar Pranay P. , Gadod Lalkar , K. S Akshay
Published: April 2023

Femur neck is anatomically weaker and prone for fractures in all age groups of population.trauma is major cause of fracture in young individuals. Neck of femur fracture are classified based on anatomical location of fracture , pauwels classification system using orientation of fracture line and gardens system based on trabecular alignment in femur head and acetabulum. In young patients open reduction and internal fixation is preferred choice but in elderly we perform arthroplasty. When fracture is more vertical there are chances of non-union due to shear forces across fracture site.In this case series all the patients are having neck of femur fracture pauwels type 3 and are managed with lateral closing wedge valgus osteotomy at level of lesser trochanter to convert shear forces into compression forces which promotes healing of fracture And fixation is done using DHS system and CC screws .all patients were mobilised with Walker by nil weight bearing initially and followed up at 2 weekly interval later gradually weight bearing started as tolerated and all shows union of fracture and osteotomy site at 12 weeks post op. Keywords: Neck of femur fracture, Pauwels type 3, Pauwels angle, DHS system, Valgus osteotomy, Compression forces
Shifting craft’s horizons: From individual makers to post-anthropocentric models of co-production
Authors: Niedderer Kristina , Townsend Katherine
Published: April 2023

This issue features the work of individual practitioners who explore making through established decorative arts such as fine jewellery in Paris, mosaic glass making in Myanmar and a ceramic installation in the Cathedral of Palma de Majorca, alongside socially engaged groups employing co-production methodologies for designing everyday objects and experiences. Within each article, materials and the immediate and wider environment are considered as partners in the co-crafting process, albeit to varying degrees. The notion of serendipity and the influence of eastern philosophy on embracing imperfection in craft practice underpins some accounts and is questioned in others. As a collection, the articles evidence a palpable shift towards, and need for a more equal relationship and level of agency between the maker and the material, as argued in the Position Paper. This includes consideration of gender equality in particular crafts, where roles are traditionally linked to the properties of the materials and skills involved, as highlighted in the Craft and Industry Report. Social engagement through craft is echoed in the Portrait where stitch and embroidery are practised as forms of participatory expression, supporting human connectivity between cross-cultural and trans-national communities to influence issues of social justice. The affective role and emotive sensations evoked by textiles are also explored in the exhibition review of A Thread, Levitated and Hovering, staged in Hangzhou in 2022 and the first of three book reviews; Feminist Subjectivities in Fiber Art and Craft (2021), the other two discussing The Pursuit of Pleasurable Work (2021) and Industrial Craft in Australia (2021).
The creation of contemporary glass mosaics inspired by ancient Burmese glass art
Authors: Wanjing Asawinee
Published: April 2023

This research studies glass decorations used in religious buildings from nineteenth-century Burma. It focuses on artworks found along the inner walls of the Buddhist shrine at Shwe Yan Pyay in Nyaungshwe City. Dating from the early nineteenth century, the shrine still serves as a Buddhist learning centre in the village and is thus an invaluable source of knowledge on Burmese and Asian art. Ancient glass artworks employed different techniques, many of which have since faded from practice, such as painting under glass or using lacquer. Their study can inform art education, promote art conservation and open new creative pathways for contemporary artists. This study has researched these ancient techniques through practice-based research and offers examples of its contemporary application.
Socially valid tools: Sloydtrukk and co-crafting togetherness
Authors: Hansson Helena , von Busch Otto
Published: April 2023

In the footsteps of specialization as well as studio crafts, making is commonly thought of as a solitary practice. The term do-it-yourself (DIY) emphasizes the singular and practical maker, empowered by his or her skills, taking action where deemed necessary. Along similar lines, tools are designed for the use by this lone maker, who seldom asks for assistance. The term co-craft, as explored in this article, suggests a collaborative mode of crafts, where participants not only work together, but become reliant on each other. Following the ideas of craftsman and thinker William Coperthwaite, such tools for togetherness make democratic ideals tangible and are ‘socially valid designs’. This article examines a series of workshops where socially valid tools are designed and implemented in Gothenburg, to model possible modes of co-craft and democratic ways of practical cultivation of craft capabilities.
A single ecstasy: Material intimacy in Miquel Barceló’s ceramics in the Cathedral of Palma de Majorca
Authors: Mato-Mora Patricia
Published: April 2023

An analysis of Miquel Barceló’s ceramic intervention in the Chapel of Saint Peter (renamed Chapel of the Holy Sacrament after the intervention), inside the Cathedral of Palma de Majorca (Spain), engenders a discussion about the relationship between the artist and his material. This analysis uses a Taoist lens to give a novel reading of the artwork, the artist’s practice, and of contemporary western notions about art, architectural space, materiality and the body. On the basis that, in Taoism, human organisms and ‘nature’ are understood to be a single integral unity, this conception is hereby extended to include matter, thus presenting a vigorous physical engagement with materiality as an ‘artful erotic contact’ between the human organism and a material.
Gender-based stereotyping in the Spanish artisan sector
Authors: González-Martín César , García-López Ana , Romero-Frías Esteban , Cano-Martínez María Jesús
Published: April 2023

Throughout history, certain stereotypes associated with the idea of feminine and masculine have been consolidated and maintained, framed within a binary sex/gender system. With the passage of time and the inclusion of women in the workplace, such stereotypes have been extrapolated to the latter, resulting in inequalities in access to certain positions and professional development. Although significant progress has been made in workplace equality, some professions continue to be characterized by a particular polarization, and within the artisan sector, this is reflected in specific trades. In this sense, this research aims to determine whether there are gender stereotypes in the Spanish artisan sector, the degree of presence of men and women in the various craft trades, and what elements facilitate this polarization. A survey of 547 craftspeople, and a review of the statistical data on the working population in Spain for the year 2020, reveals a perpetuation of gender segregation depending on the craft trade, along with an ageing sector, and continued stereotyping in the generational replacement in the Spanish craft sector.
Tying the knots
Authors: Kettle Alice
Published: April 2023

Alice Kettle’s stitched works can be viewed in the canon of English figurative embroidery. She uses stitch and thread as a narrative device and as a connecting line, which ties together individual and collective stories as multiple strands across time. The article gives an overview of Kettle’s works which integrate autobiography with mythology and contemporary event, tracing the lineage practices of women and offering a feminine viewpoint to chronicle experience. The works document the recent histories of sociopolitical disruption in Europe, which heralded the fragmentation of unity and Brexit. The recent project Thread Bearing Witness concerns people displacement, migration and global conflict. Stitch is used as a means to represent the marginalized and multiple voices of refugees and those seeking asylum. Stitch is viewed as an expressive and empowering means to change perceptions, promote change and as a common language of making.
Industrial Craft in Australia: Oral Histories of Creativity and Survival, Jesse Adams Stein (2021)
Authors: Haskell Natalie
Published: April 2023

Review of: Industrial Craft in Australia: Oral Histories of Creativity and Survival, Jesse Adams Stein (2021)

Cham: Palgrave Macmillan, 252 pp.,

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