bluuebunny/crossref_metadata_2025 huggingface dataset:
Aurora-A Regulates Progression and Metastasis of Colorectal Cancer by Promoting Slug Activity
Authors: He Jin-Guang , Li Luming , Qin Ying , Yu Wenfei , He Xiuquan , Gang Ren
Published: December 2017

Epithelial–mesenchymal transition (EMT) is associated with cancer metastasis and poor prognosis, but the exact mechanism has not been clarified. Centrosomal Aurora-A kinase gene is frequently overexpressed in a variety of cancers and plays a pivotal role in the growth and survival of cancer cells. However, its role in colorectal cancer metastasis has not been confirmed. Here we demonstrate that Aurora-A plays a crucial role in the progression and metastasis of colorectal cancer by regulating epithelial–mesenchymal transition. In our study, increased Aurora-A expression was detected in colorectal cancer clinical specimens compared to normal colorectal tissues. Moreover, overexpressed Aurora-A significantly promoted the proliferation, migration, and invasion capacity of colorectal cancer cells and then enhanced metastatic capacity of colorectal cancer in vitro and in vivo and eventually led to poor prognosis. Conversely, silencing Aurora-A expression in colorectal cancer cells decreased the capacity of proliferation, migration, and invasion and further reduced colorectal cancer metastasis. Mechanistically, we found that Slug was involved in Aurora-A–induced migration and invasion of colorectal cancer cells. Silencing Slug expression could block Aurora-A–induced migration, invasion, and metastasis of colorectal cancer cells. Furthermore, the expression of Aurora-A and Slug were positively correlated in colorectal cancer tissues and paired normal colorectal tissue. Taken together, our findings revealed a critical role of Aurora-A in colorectal cancer progression and metastasis by regulating epithelial–mesenchymal transition.
Immunotherapy Strategies Against Multiple Myeloma
Authors: Ma Jing , Li Qian , Yu Zhen , Cao Zeng , Liu Su , Chen Lin , Li Han , Gao Shuang , Yan Tinghui , Wang Yafei , Liu Qiang
Published: December 2017

Multiple myeloma is a monoclonal B-cell malignancy characterized by an accumulation of malignant plasma cells in the bone marrow, the presence of a monoclonal protein in the serum and/or urine, decreased normal immunoglobulin levels, and lytic bone disease. Patients with multiple myeloma benefit from combination therapy including novel therapeutic agents followed by autologous stem cell transplantation prolonged maintenance therapy. However, multiple myeloma remains incurable; most patients with multiple myeloma will eventually become resistant to chemotherapy, and progression or relapse of the disease is inevitable. Immunotherapy represents a novel therapeutic approach with few adverse effects and good targeting capability that might be a powerful pool to allow long-term control of minimal residual disease. This article reviews the literature evaluating 4 major immunotherapeutic approaches for multiple myeloma including cellular immunotherapy, humoral immunotherapy, radio immunotherapy, and immunomodulation.
Prognostic Role of Long Noncoding RNA BANCR in Solid Tumors: A Meta-Analysis
Authors: Zhao Jun , Qi Yali , Hu Jiahao , Dai Wenwen , Chen Yifei
Published: December 2017

Accumulating studies have reported that long noncoding RNA BRAF-activated nonprotein coding RNA plays vital role in various cancers. However, the prognostic values of BRAF-activated nonprotein coding RNA in solid tumors remain controversial. Thus, we assessed the prognostic values of BRAF-activated nonprotein coding RNA by this meta-analysis. We comprehensively searched PubMed, Web of Science, Medline, China National Knowledge Infrastructure (CNKI), and the Cochrane Library at November 2016. After carefully screening, we ultimately included 14 studies in this meta-analysis. This meta-analysis brought all relevant articles into determining the association of BRAF-activated nonprotein coding RNA expression with overall survival and clinicopathologic features. The results showed that high BRAF-activated nonprotein coding RNA expression significantly shorten the overall survival of solid tumors (pooled hazard ratios 1.66, 95% confidence interval: 1.19-2.32). Moreover, high BRAF-activated nonprotein coding RNA expression was also strongly associated with advanced tumor stage (odds ratios = 2.57, 95% confidence interval: 1.14-5.79), differentiation grade (odds ratio = 1.71, 95% confidence interval: 1.26-2.31), lymph node metastasis (odds ratio = 2.67, 95% confidence interval: 1.93-3.70, P < .001), and distant metastasis (odds ratio = 2.98, 95% confidence interval: 1.76-5.07, P = .02). In conclusion, this meta-analysis demonstrated that high BRAF-activated nonprotein coding RNA expression may be a potential novel biomarker for indicating a poor prognosis and progression in human solid tumors.
DNA Methylation Markers Improve the Sensitivity of Endoscopic Retrograde Cholangiopancreatography-Based Brushing Cytology in Extrahepatic Cholangiocarcinoma
Authors: Prachayakul Varayu , Kanchanapermpoon Jiraporn , Thuwajit Chanitra , Boonyaarunnate Thiraphon , Pongpaibul Ananya , Chobson Pornpimol , Thuwajit Peti
Published: December 2017

Endoscopic retrograde cholangiopancreatography with brushed cytology is still the standard method for the diagnosis of extrahepatic cholangiocarcinoma in obstructive jaundice; however, the diagnostic yield is limited. To improve the diagnostic sensitivity, DNA methylation analysis is an attractive candidate, since this may constitute a stable marker in brushed specimens. Therefore, this study aims to evaluate the importance of such epigenetic markers in brushed biliary cells from patients with obstructive jaundice for the diagnosis of extrahepatic cholangiocarcinoma. The cells examined were those that were left over from brushed cytology done during routine endoscopic retrograde cholangiopancreatography of patients with extrahepatic cholangiocarcinoma. The methylation states of HOXA1, RASSF1A, P16, and NEUROG1 genes in extrahepatic cholangiocarcinoma were measured by quantitative methylation-specific polymerase chain reaction and compared between brushed biliary cells and normal gall bladder epithelial cells. The results showed that the sensitivity of the methylation index measurements of HOXA1 and NEUROG1 genes from brushed samples was markedly superior to that of standard cytology. In conclusion, measurement of the DNA methylation status of HOXA1 and NEUROG1 genes in leftover brushed biliary cells might serve as a useful supplement in the detection of malignant biliary obstruction by increasing the sensitivity of diagnosis by routine cytology.
Can BRICS build ivory towers of excellence? Giving new meaning to world-class universities
Authors: David Solomon Arulraj , Motala Shireen
Published: December 2017

This paper aims to map the landscape of higher education transformation in the BRICS (Brazil, Russia, India, China and South Africa) nations while exploring the status of BRICS nations in some of the global university rankings and analysing their potential to give new meaning to notions such as excellent and world-class universities. The study provides different theoretical perspectives about global university ranking and about the notion of ‘world-class/excellence’. Based on the literature exploration, the gathered data from some of the global university ranking agencies and the critical reflections from purposefully selected respondents, it is considered that the quest for world-class universities is articulated in several public policy documents of BRICS nations. While some attempts to achieve this quest vary (e.g. from China’s strong effort to India’s least effort), BRICS nations, like many other nations, seem to evolve towards this ambition, as universities have become the centre point of the development agenda. The ability of BRICS nations to provide new meaning to ‘world-class/excellence’ notions, although not clear, cannot be disputed given the indications that the BRICS bloc is emerging as an alternative economic force and the role higher education is playing in this emergence.
Two worlds of educational research? Comparing the levels, objects, disciplines, methodologies, and themes in educational research in the UK and Germany, 2005–2015
Authors: Zapp Mike , Marques Marcelo , Powell Justin JW
Published: December 2017

Embedded in social worlds, education systems and research reflect distinct national trajectories. We compare two contrasting traditions of educational research (ER). Whereas British ER exhibits a multidisciplinary and pragmatic character, German ER reflects pedagogy and mainly humanities-based traditions. Yet, in both countries, policymakers’ growing demand for evidence in ER resulted in increased funding, specific research programs, and mandatory large-scale assessments. These have reshaped the field, suggesting more similar ER agendas. Based on a comprehensive original dataset of basic ER projects funded by the main grant-making agencies in both countries (2005–2015), we analyze five dimensions: levels, objects, disciplines, methodologies, and themes. We find epistemic drift, with partial convergence characterized by a multi-level focus, multidisciplinary approach, strongly empirical and quantitative methodology, and a premium on teaching and learning themes. The cases remain distinct in exploring systemic questions in a wider contextual frame (UK) or concentrating more narrowly on the individual learner (Germany).
Universality of culture and neo-intuitionalism: Do they make a difference to comparative education?
Authors: Mohammad Amal Abdel Fattah
Published: December 2017

Comparative education (CE) addresses culture through the lens of global culture which increasingly puts so much emphasis on human capital. Also, convergence of educational systems has become one of the main issues of global culture in CE, particularly with so many nationalities melting into the global society to become part and parcel of the global culture network. As a result, these nationalities have been under considerable pressure to accredit and adopt similar institutional structures including models of bureaucracy, inclusive education, democratic transition, and spread of science which is based on universities and social sciences, all of which are considered as major knowledge systems. In addition, there are calls for growing interest in the contributions of neo-institutional theory as a distinct approach to the study of social, economic, political and educational phenomena, particularly in the field of CE because it takes into account the dual power of globalization and contextualization and accommodates the multi-directional influence on the macro-level educational phenomenon and both the institutional and individual level. Hence, the current research aims mainly at identifying the most significant changes in culture, particularly global culture. It also investigates the effective roles these changes play in the field of CE and their relation to the neo-institutional theory. Finally, it aims at developing a number of recommendations to promote the institutional construction of CE at the Faculties of Education in Egyptian universities.
Impact of identity politics on education in Pakistan: A comparison between Balochistan and Punjab
Authors: Nasser Ammna , Kyriazi Tenia , Paris Cody Morris , Ahmad Mahine
Published: December 2017

This research article examines the impact of ethnic identity-based politics on education in Pakistan through in-depth interviews with young professionals from Balochistan and Punjab. The findings suggest that the Punjabi-dominated power structure results in an unequal allocation of financial resources, whereby Balochistan lacks the financial resources to invest in education development. In addition, political instability caused by unprecedented ethnic strife contributes towards poor-quality education, which, as a result, adversely impacts a Balochi’s future course of life. On the other hand, Punjabis are at an advantage in the public arena because of their robust educational foundation.
Amateur Theatricals and the Dramatic Marketplace: Lacy’s and French’s Acting Editions of Plays
Authors: Weig Heidi
Published: December 2017

Historically an exclusive, upper-class entertainment, private theatricals became a widespread, primarily middle-class pastime in the course of the nineteenth century. To the emerging bourgeoisie, play-acting represented an important way to negotiate class identity by emulating the habits of social elites. The foremost raw materials for private stagings of drama were the acting editions of plays published most prolifically in the second half of the century by T. H. Lacy and Samuel French, consecutively. This paper examines Lacy’s and French’s publication and marketing strategies by placing side by side guide literature and play series issued by them, to illuminate the impact these strategies had on the dramatic marketplace, and the way that Lacy, in particular, engaged social anxieties about the theatre in establishing his business concept. It then traces the changing composition of Lacy’s and French’s Acting Editions to highlight a significant increase in plays by women from the 1880s onwards. I argue that this increase expresses the evolution of amateur theatricals into a distinctly middle-class social practice because the female dramatists that French’s favoured, produced work congruent with bourgeois interest in morally sound, domestic topics and educational value, and recommended themselves through the respectable public personas they created for themselves.
Hypersensitivity reactions to human insulin analogs in insulin-naïve patients: a systematic review
Authors: Bzowyckyj Andrew S. , Stahnke Amanda M.
Published: December 2017

Objective:

The objective of this study was to raise awareness of hypersensitivity reactions to human insulin analogs (HIAs) in insulin-naïve patients and encourage consistent and detailed reporting of HIA reactions.

Data sources:

A search of PubMed, MEDLINE and International Pharmaceutical Abstracts using the terms ‘insulin’ and ‘hypersensitivity’ was completed with English language, humans, and publication date after 1 January 1990 as limits.

Study selection and data extraction:

The initial search identified 598 articles. These titles and abstracts were reviewed for relevance (e.g. mention of HIA) resulting in the exclusion of 477 articles. The full texts of the remaining titles were evaluated in addition to each article’s references to identify additional reports meeting criteria ( n = 14). Upon extensive review, 118 articles were excluded for not meeting prespecified inclusion criteria, resulting in 17 articles.

Data synthesis:

Evidence supporting hypersensitivity reactions to HIAs was variable, potentially due to a variety of causes (e.g. difficulty identifying a true case of hypersensitivity reaction to HIAs). Inconsistencies were noted for the identification, confirmatory testing, management, and reporting of these reactions. Management strategies included use of insulin desensitization protocols, antihistamines, steroids, immunosuppressant/immunomodulator therapies, conversion to noninsulin therapies, and pancreas transplantation.

Conclusions:

Complete and consistent identification, evaluation, management, and reporting of these reactions is essential. Specific aspects of the patient’s history should be reported, including previous insulin exposure, the specific HIAs used, duration of use prior to the reaction, a clear timeline of the reaction, and discussion of precipitating events or confounding factors.
Observational Study of the Association Between Tongue Exam and the Kampo Diagnostic Procedure of Fuku Shin (Abdominal Exam) in Blood Stasis
Authors: Arai Young-Chang , Aono Shuichi , Makino Izumi , Nishihara Makoto , Ikemoto Tatsunori , Owari Keiko
Published: December 2017

Blood stasis is a very important pathophysiological concept not only in Kampo but also in traditional Chinese medicine. Blood stasis indicates severe disease. Fuku shin (the abdominal exam) and Zetsu shin (the tongue exam) are the most important approaches of the 4 diagnostic procedures in Kampo. Tenderness of the lower abdominal region ( Sho fuku koh man) and distended sublingual veins have been mentioned as typical signs of blood stasis in Kampo or traditional Chinese medicine. The aim of the present study was to determine the association between Sho fuku koh man and distended sublingual veins. An appearance of sublingual veins and a level of Sho fuku koh man showed a significant and positive correlation ( rs = .5248; n = 279; P < .0001). In conclusion, the relationship between the appearance of sublingual veins and the level of Sho fuku koh man showed a significant and positive correlation.
Investigating Chemical Composition and Indications of Hydrosol Soft Drinks (Aromatic Waters) Used in Persian Folk Medicine for Women’s Hormonal and Reproductive Health Conditions
Authors: Hamedi Azadeh , Afifi Mehdi , Etemadfard Hamed
Published: December 2017

Hydrosol soft drinks in Persian nutrition culture are produced as side products of the essential oil industry to be used as safe remedies for treatment of some ailments. This study investigated hydrosols for women’s hormonal health conditions. Detailed information was gathered by questionnaires. Chemical constituents of these mono- or poly-herbal hydrosols were identified after liquid/liquid extraction and gas chromatography–mass spectrometry. Hierarchical cluster and K-means analysis (SPSS software) were used to find their relevance. A literature survey was also performed. In most cases, thymol, carvacrol, and carvone were the major constituents except for dill, white horehound, willow, Moderr, and yarrow hydrosols, whose their major components were dill ether, menthol, phenethyl alcohol, linalool, or camphor. Based on clustering methods, some similarities could be found in their constituents with some exceptions. None of them have been studied scientifically before. These investigations may lead to the development of some functional drinks or even new lead components.
A Review of the Antioxidant Activity of Celery (Apium graveolens L)
Authors: Kooti Wesam , Daraei Nahid
Published: December 2017

Plants are an important source of natural active products that are different, based on mechanism and biological properties. Celery ( Apium graveolens L) is a plant from the apiaceae family and phenolic and antioxidant compounds of this plant have been studied by several scientists. The aim of this study was to review systematically the antioxidant activity of celery. Required articles were searched from databases such as Science Direct, PubMed, Scopus, and Springer. Keywords used in this study were Apium graveolens L, celery, antioxidant, free radical, leaf, and seed. Out of 980 collected articles (published in the period 1997-2015), 9 studies finally met the inclusion criteria and were considered. Celery, because of compounds such as caffeic acid, p-coumaric acid, ferulic acid, apigenin, luteolin, tannin, saponin, and kaempferol, has powerful antioxidant characteristics, to remove free radicals. It is clear that celery, with different compounds and diverse concentration can have varied healing effects. It is suggested that the next studies concentrate on other therapeutic and industrial attributes of celery.
Investigation of the Mechanism of Anti-Inflammatory Action and Cytotoxicity of a Semipurified Fraction and Isolated Compounds From the Leaf of Peltophorum africanum (Fabaceae)
Authors: Adebayo Salmon A. , Steel Helen C. , Shai Leshweni J. , Eloff Jacobus N.
Published: December 2017

Peltophorum africanum extracts have been shown to possess many important medicinal benefits, including anti-inflammatory and antiviral activities. However, the mechanism of action is poorly understood. The mechanism of anti-inflammatory action was determined by measuring the synthesis of cytokines in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage cells in vitro. Compound 1 (CP1), compound 2 (CP2), and fraction F3.3.0 (F3.3.0) significantly reduced the synthesis of interleukin 1β (IL-1β) from RAW 264.7 cells (1.18, 1.32, and 0.92 ng/mL), respectively. Similarly, CP1, CP2, and F3.3.0 inhibited the production of IL-2 and tumor necrosis factor–α (TNF-α) by RAW 264.7 cells (0.41, 0.60, 0.74 and 0.11, 0.27, 0.24 ng/mL, respectively. In addition, CP1 and CP2 had lower cytotoxicity toward RAW 264.7 cells, with CP2 indicating the lowest cytotoxicity (LD50 = 207.88 µg/mL). The mechanism of action was found to be via the inhibition of pro-inflammation cytokines (IL-1 β and TNF-α). This observation may support the use of P africanum to treat pain-related conditions.
Israel–China Relations Enter a New Stage: Limited Strategic Hedging
Authors: Chaziza Mordechai
Published: December 2017

Since the establishment of diplomatic ties between China and Israel in 1992, their relations have warmed up and developed rapidly in diverse areas. This study offers a new theoretical framework, strategic hedging behavior, for analyzing Sino-Israel relations, in order to understand the nature and scope of the hedging relationship between China and Israel. What impact will China’s hedging relationship with Israel have on Washington’s dominance in the Middle East region? The study asserts that this relationship is limited to economics and technology, and China’s relations with Israel cannot replace Israel’s strategic and special relationship with the US. However, the future of the hedging relationship countries is highly sensitive to the evolution of US–China relations in the Middle East and other areas.
Can Digital Technologies Play a Role in Improving Children’s Learning Outcomes in India?
Authors: Banerjee Sashwati , Chakravarty Sujoy , Joshi Ira , Pillai Siddharth
Published: December 2017

In this study, we explore the effects of an educational intervention in the form of digital games targeted towards improving the learning outcomes in mathematics and Hindi language among first, second and third graders in four government schools in southern New Delhi. In addition to administering these games in the classroom, we randomly recruited 40 households from a low-income community, where children play the games as an extra-curricular activity. We measure the improvement in aptitude in math and Hindi pre- and post-intervention, using various demographic controls and find that the community intervention had some impact in boosting aptitude. In contrast, the school intervention did not show the desired results though it did register some improvement in children’s knowledge. Using qualitative observation coupled with the quantitative assessment of impact, we attempt to deconstruct the various infrastructural challenges and sampling issues posed in our school intervention, and identify key features that need to be adhered to for future researchers who may want to assess the impact of educational interventions on young children from underprivileged backgrounds in India.
Social Sector Expenditure in India in the 2000s: Trends and Implications
Authors: Chattopadhyay Soumyadip
Published: December 2017

Acknowledging the contribution of social infrastructure towards building up human capital, this article analyses the trend and pattern of social sector expenditure in India in the 2000s. Rhetorical commitment of successive Indian governments towards inclusive social development and poverty alleviation in the 2000s has not been backed up by adequate financial allocations and this has merely served to maintain the status quo on social sector spending. The new pattern of tax shares between the centre and states has resulted in higher inflow of ‘untied fund’ from the central government accompanied by lower allocations of ‘tied fund’. Subsequently, states have not exhibited any definitive sign of using their newly accrued fiscal autonomy to prioritise social sector expenditure. Along with greater public investment for development of human resources, this article emphasises on the need for appropriate monitoring and evaluation framework, and change in the budget making policy with greater involvement of people directly affected by changes in public policies related to social sector.
A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance
Authors: Ward Soracha E. , O’Sullivan Jamie M. , Drakeford Clive , Aguila Sonia , Jondle Christopher N. , Sharma Jyotika , Fallon Padraic G. , Brophy Teresa M. , Preston Roger J. S. , Smyth Paul , Sheils Orla , Chion Alain , O’Donnell James S.
Published: December 2017

Key Points

VWF sialylation modulates in vivo clearance through Ashwell-Morrell independent pathways. VWF binding to MGL plays a novel role in facilitating VWF clearance.
Genome of Russian wheat aphid an economically important cereal aphid
Authors: Burger Nicolaas Francois Visser , Botha Anna-Maria
Published: December 2017

Although the hemipterans (Aphididae) are comprised of roughly 50,000 extant insect species, only four have sequenced genomes that are publically available, namely
Acyrthosiphon pisum
(pea aphid),
Rhodnius prolixus
(Kissing bug),
Myzus persicae
(Green peach aphid) and
Diuraphis noxia
(Russian wheat aphid). As a significant proportion of agricultural pests are phloem feeding aphids, it is crucial for sustained global food security that a greater understanding of the genomic and molecular functioning of this family be elucidated. Recently, the genome of US D. noxia biotype US2 was sequenced but its assembly only incorporated ~ 32% of produced reads and contained a surprisingly low gene count when compared to that of the model/first sequenced aphid,
A. pisum
. To this end, we present here the genomes of two South African
Diuraphis noxia
(Kurdjumov, Hemiptera: Aphididae) biotypes (SA1 and SAM), obtained after sequencing the genomes of the only two D. noxia biotypes with documented linked genealogy. To better understand overall targets and patterns of heterozygosity, we also sequenced a pooled sample of 9 geographically separated D. noxia populations (MixIX). We assembled a 399 Mb reference genome (PRJNA297165, representing 64% of the projected genome size 623 Mb) using ± 28 Gb of 101 bp paired-end HiSeq2000 reads from the D. noxia biotype SAM, whilst ± 13 Gb 101 bp paired-end HiSeq2000 reads from the D. noxia biotype SA1 were generated to facilitate genomic comparisons between the two biotypes. Sequencing the MixIX sample yielded ±26 Gb 50 bp paired-end SOLiD reads which facilitated SNP detection when compared to the D. noxia biotype SAM assembly. Ab initio gene calling produced a total of 31,885 protein coding genes from the assembled contigs spanning ~ 399 Mb (GCA_001465515.1).
Ground deformation and fault modeling of the 2016 sequence (24 Aug. – 30 Oct.) in central Apennines (Central Italy)
Authors: Pavlides Spyros , Chatzipetros Alexandros , Papathanasiou George , Georgiadis George , Sboras Sotiris , Valkaniotis Sotiris
Published: December 2017

A chain fault reactivation took place in central Apennines, from August 24 to October 30, 2016, producing five moderate-to-strong earthquakes ranging from Mw5.5 to Mw6.6. This paper presents the results from the study of the ground co-seismic ruptures around the Monte Vettore and Vettoretto, and Norcia. Surface co-seismic ruptures, were observed in the Vettore and Vettoretto segment of the fault for some kilometers (~7 km) in the August earthquakes, which were partly re-activated  and  expanded  northward  during  the  October  earthquakes.  Ruptures  with  5-15  cm displacements are observed both in scree and weathered mantle (elluvium) and the bedrock, mainly fragmented carbonate rocks with small tectonic surfaces. After the October seismic sequence the co-seismic displacement doubled and reached more than 50cm. Oblique low-altitude aerial images were acquired at several sites using a UAV and 3D models were constructed using photogrammetric extrapolation. Numerous observed and mapped rock falls, slides of earth-materials etc, occur mainly along the mountain roads, on artificial slopes. They were studied with preliminary mapping from satellite imagery, and examples are presented of large landslides in the epicentral region with pre and after- the earthquake images. The first four events are associated with four individual fault segments respectively, all aligned along the mountain-fronts of Mt Gorzano and Mt Vettore. The last fifth and strongest event was the result of linkage and breaching of the previous fault segments. We modelled the fault segments intofive seismogenic sources in order to calculate the post-sequence static stress changes produced by the five seismogenic sources (or source faults) to the surrounding faults (receiver faults). Our results suggest possible triggering effects for neighbouring faults located along the strike of the source faults and delay effects for faults which are directly located either on the footwall or hanging-wall.
Geological and seismological evidence for NW-SE crustal extension at the southern margin of Heraklion basin, Crete.
Authors: Ganas Athanassios , Fassoulas Charalambos , Moshou Alexandra , Bozionelos George , Papathanassiou George , Tsimi Christina , Valkaniotis Sotirios
Published: December 2017

In this paper we present new geological and seismological data on the orientation of crustal extension in central Crete (SE Heraklion basin) following the occurrence of two shallow seismic sequences: a) the May 2005 Assimi M=4.1 earthquake sequence and b) the 2013 Houdetsi-Tefeli sequence (3.2≤Mw≤3.6). Emphasis is given to the results of the geological field work, stress analysis, source inversion, aftershock relocations and mapping of earthquake-induced environmental effects. For the first time we find seismological evidence for N-S strike-slip motions along shallow fault planes in central Crete (Amourgeles fault). Our results indicate that while crustal extension dominates there is a combination of active fault kinematics, ranging from normal faulting along the northern edge of Messara basin (south-dipping Plakiotissa fault) to strike-slip faulting inside the SE part Heraklion basin (Houdetsi-Tefeli). The combination of active fault motions accommodates a NW-SE extension of the upper crust.
Patent foramen ovale closure versus medical therapy for stroke prevention: A systematic review and meta-analysis of randomized controlled trials
Authors: Tse Gary , Wu William K.K. , Gong Mengqi , Bazoukis George , Wong Wing Tak , Wong Sunny Hei , Lampropoulos Konstantinos , Baranchuk Adrian , Tse Lap Ah , Xia Yunlong , Li Guangping , Wong Martin C.S. , Chan Yat Sun , Mu Nan , Dong Mei , Liu Tong ,   International Health Informatics Study (IHIS) Network
Published: December 2017

Background: Previous randomized trials on patent foramen ovale (PFO) closure versus medical therapy for stroke prevention were inconclusive. Recently, two new randomized trials and new findings from an extended follow-up of a previous trial have been published on this topic. We conducted a systematic review and meta-analysis of randomized trials comparing PFO closure with medical therapy for stroke prevention.

Methods: PubMed and Cochrane Library were searched until 16th September 2017.  The following search terms were used for PubMed: "patent foramen ovale" AND (stroke OR embolism) and "randomized" AND "Trial". For Cochrane Library, the following terms were used: "patent foramen ovale" AND "closure" AND (stroke OR embolism).

Results: A total of 91 and 55 entries were retrieved from each database using our search strategy respectively, of which six studies on five trials met the inclusion criteria. This meta-analysis included 1829 patients in the PFO closure arm (mean age: 45.3 years; 54% male) and 1972 patients in the medical therapy arm (mean age: 45.1 years; 51% male). The median follow-up duration was 50 ± 30 months. When compared to medical therapy, PFO closure significantly reduced primary endpoint events with a risk ratio [RR] of 0.60 (95% CI: 0.44-0.83, P < 0.0001; I2: 15%). It also reduced stroke (RR: 0.50, 95% CI: 0.35-0.73, P < 0.0001; I2: 32%) despite increasing the risk of atrial fibrillation/flutter (RR: 1.90, 95% CI: 1.23-2.93, P < 0.01; I2: 43%). However, it did not reduce transient ischemic accident events (0.75; 95% CI: 0.51-1.10, P = 0.14; I2: 0%), all-cause bleeding (RR: 0.89; 95% CI: 0.44-1.78, P = 0.74; I2: 51%) or gastrointestinal complications (RR: 0.92; 95% CI: 0.32-2.70, P = 0.88; I2: 0%).

Conclusions: PFO closure significantly reduces risk of stroke when compared to medical treatment and should therefore be considered for stroke prevention in PFO patients.
Features of the impact of the solar wind diamagnetic structure on Earth’s magnetosphere
Authors: Пархомов Владимир , Parhomov Vladimir , Бородкова Наталия , Borodkova Natalia , Еселевич Виктор , Eselevich Viktor , Еселевич Максим , Eselevich Maxim , Дмитриев Алексей , Dmitriev Aleksey , Чиликин Виталий , Chilikin Vitaliy
Published: December 2017

In Earth’s orbit on June 28, 1999, there was a diamagnetic structure (DS) representing a filament with a uniquely high speed (about 900 km/s). We show that the filament is a part of the specific sporadic solar wind (SW) stream, which is characterized as a small interplanetary transient. We report the results of studies on the interaction between such a fast filament (DS) and Earth’s magnetosphere. Around noon hours at daytime cusp latitudes, we recorded a powerful aurora in the UV band (shockaurora), which rapidly spread to the west and east. Ground-based observations of geomagnetic field variations, auroral absorption, and auroras on the midnight meridian have shown the development of a powerful substorm-like disturbance (SLD) (AE~1000 nT), whose origin is associated with the impact of the SW diamagnetic structure on the magnetosphere. The geostationary satellite GOES-8, which was in the midnight sector of the outer quasi-capture region during SLD, recorded variations of the Bz and Bx geomagnetic field components corresponding to the dipolarization process.
First results of registering ionospheric disturbances obtained with SibNet network of GNSS receivers in active space experiments
Authors: Ишин Артем , Ishin Artem , Перевалова Наталья , Perevalova Natalia , Воейков Сергей , Voeykov Sergey , Хахинов Виталий , Khakhinov Vitaliy
Published: December 2017

Global and regional networks of GNSS receivers have been successfully used for geophysical research for many years; the number of continuous GNSS stations in the world is steadily growing. The article presents the first results of the use of a new regional network of GNSS stations (SibNet) in active space experiments. The Institute of Solar-Terrestrial Physics of Siberian Branch of Russian Academy of Sciences (ISTP SB RAS) has established this network in the South Baikal region. We describe in detail SibNet, characteristics of receivers in use, parameters of antennas and methods of their installation. We also present the general structure of observation site and the plot of coverage of the receiver operating zone at 50–55° latitudes by radio paths. It is shown that the selected location of receivers allows us to detect ionospheric irregularities of various scales. The purpose of the active space experiments was to reveal and record parameters of the ionospheric irregularities caused by effects from jet streams of Progress cargo spacecraft. The mapping technique enabled us to identify weak, vertically localized ionospheric irregularities and associate them with the Progress spacecraft engine impact. Thus, it has been shown that the SibNet deployed in the Southern Baikal region is an effective instrument to monitor ionospheric conditions.
Robust Randomized Matchings
Authors: Matuschke Jannik , Skutella Martin , Soto José A.
Published: December 2017

The following game is played on a weighted graph: Alice selects a matching M and Bob selects a number k. Alice’s payoff is the ratio of the weight of the k heaviest edges of M to the maximum weight of a matching of size at most k. If M guarantees a payoff of at least α then it is called α-robust. In 2002, Hassin and Rubinstein gave an algorithm that returns a [Formula: see text]-robust matching, which is best possible.

We show that Alice can improve her payoff to 1/ln(4) by playing a randomized strategy. This result extends to a very general class of independence systems that includes matroid intersection, b-matchings, and strong 2-exchange systems. It also implies an improved approximation factor for a stochastic optimization variant known as the maximum priority matching problem and translates to an asymptotic robustness guarantee for deterministic matchings, in which Bob can only select numbers larger than a given constant. Moreover, we give a new LP-based proof of Hassin and Rubinstein’s bound.
Salmon Plan Wins Environmental Award
Authors: Merritt Margaret
Published: December 2017

The Matanuska-Susitna (Mat-Su) Salmon Research, Monitoring and Evaluation Plan for Upper Cook Inlet, Alaska was the winner in the Environmental category of the Alaska Chapter, American Planning Association (APA) 2015 Awards program. The plan, which used the Analytic Hierarchy Process (AHP) to identify, structure and prioritize specific issues related to program goals and objectives, was showcased in November, 2015 during the APA’s annual convention in Anchorage, Alaska.https://doi.org/10.13033/ijahp.v9i3.512
REFLECTIONS: MATHEMATICAL PRINCIPLES OF DECISION MAKING
Authors: Karpak Birsen
Published: December 2017

This article discusses my reflections on Mathematical Principles of Decision Making by Thomas Saaty  (Saaty T. L., 2010). In this book, Saaty very clearly explains his Analytic Hierarchy Process (AHP) theory for measuring both tangible and intangible factors. Experts judgments are elicited about the dominance of a factor over another one via pairwise comparisons using an absolute scale and priorities of the factors are derived. The important concepts of the AHP such as compatibility index, validation, sensitivity analysis for testing the robustness of the priorities derived, and its generalization to structures with dependence and feedback, and the Analytic Network Process (ANP) are given. Extensions of the theory to complex decisions involving benefits, opportunities, costs and risks and applications to resource allocation and conflict resolution are included, as well as the generalization to continuous and time dependent judgments is also covered.https://doi.org/10.13033/ijahp.v9i3.521
GROUP DECISION MAKING: DRAWING OUT AND RECONCILING DIFFERENCES
Authors: Peniwati Kirti
Published: December 2017

Why is group decision making so important today?  In our increasingly complex environment, decision making becomes more and more challenging for leaders and practitioners.  Working in groups appears to be the norm because the alignment of visions and actions are critical for an organization. A leader or a group facilitator needs a supporting system to make collective thinking effective. The book, Group Decision Making: Drawing out and Reconciling Differences, written by Thomas Saaty and myself shows that the AHP is the scientific approach for supporting group processes in the current and future complex environment (Saaty & Peniwati, 2008). https://doi.org/10.13033/ijahp.v9i3.533
Words from the Special Issue Editor
Authors: Saaty Rozann W.
Published: December 2017

It has been very gratifying to me to edit this memorial issue of the IJAHP in honor of Tom Saaty, my husband of 53 years.https://doi.org/10.13033/ijahp.v9i3.555
Job Satisfaction of People With Intellectual Disability: Associations With Job Characteristics and Personality
Authors: Akkerman Alma , Kef Sabina , Meininger Herman P.
Published: December 2017

To obtain an understanding of factors associated with job satisfaction of people with intellectual disability (ID), this study investigates the associations of job satisfaction with job characteristics (i.e., job demands, job resources) and personality, using the job demands-resources model. Data were gathered from 117 people and their employment support workers, using structured questionnaires adapted from well-established instruments. Job resources and age were positively associated with job satisfaction. Job demands and personality showed no significant direct associations with job satisfaction. Moderation analyses showed that for people with ID with high conscientiousness, enhanced job demands were associated with reduced job satisfaction, which was not the case for those with low conscientiousness. This study emphasizes the importance of job design.
The Local versus the Global in Curating and Curatorial Pedagogy
Authors: Jones Amelia
Published: December 2017

Based on the specific structure of the new University of Southern California, Roski School of Art and Design curriculum of the MA in Curatorial Practices, this article polemically examines current tendencies in curating and curatorial practices programmes, arguing that there is an important role to be played by the latter – but not, as is often argued, in extending the reach of the self-proclaimed ‘global’ art world. The role of curatorial pedagogy, to the contrary, might best be understood as a critical one in giving students tools to understand the dangerous history behind claims of the ‘global’, which resonate with colonialist and imperialist and capitalist ideologies that have, since the early modern period, defined ‘art’ as such in Europe and European-based cultures.
Exhibition Reviews
Authors: Racevičiūte Barbora , Lau Charlene K. , Syperek Pandora , Allen Fiona , Landbrecht Christina , Xiang Joy
Published: December 2017

IN SEARCH OF EXPO 67

Curated by Lesley Johnstone and Monika Kin Gagnon, Musée d’art contemporain de Montréal, Montreal, 26 June – 1 November 2017

SARA BERMAN’S CLOSET

The Met Fifth Avenue, New York, 6 March – 26 November 2017

OFFSHORE: ARTISTS EXPLORE THE SEA

Ferens Art Gallery and Hull Maritime Museum, Hull, United Kingdom, 1 April – 28 August 2017

56 ARTILLERY LANE

Curated by Amy Budd and Naomi Pearce, Raven Row, London, 21 April – 11 June 2017

LEARNING FROM ATHENS

Documenta 14, curated by Adam Szymczyk (along with Pierre Bal-Blanc, Hendrik Folkerts, Candice Hopkins, Hila Peleg, Paul B. Preciado, Dieter Roelstaete, Bonaventure Soh Bejeng Ndikung and Monika Szewczyk), Athens, 8 April – 16 July 2017

VIVIENNE WESTWOOD: GET A LIFE!

Curated by Alex Krenn, chi K11 art space, K11 Art Mall, Shanghai, 20 December 2016 – 28 February 2017
Book Reviews
Authors: Kompatsiaris Panos , Zitzewitz Karin
Published: December 2017

BIENNIALS, TRIENNIALS, AND DOCUMENTA: THE EXHIBITIONS THAT CREATED CONTEMPORARY ART, CHARLES GREEN AND ANTHONY GARDNER Oxford: Wiley-Blackwell (2016), 304 pp., Paperback, ISBN: 978-1-44433-665-8, US $39.95

DISPLAYING TIME: THE MANY TEMPORALITIES OF THE FESTIVAL OF INDIA, REBECCA M. BROWN Seattle and London: University of Washington Press (2017), 248 pp., Paperback, ISBN: 978-0-29574-198-7, US $30.00
Comparison of respiratory parameters with and without mouth guard in Karate Players
Karatecilerde ağız koruyuculu ve ağız koruyucusuz ölçülen solunum parametrelerinin karşılaştırılması
Authors: Soykan Aytekin , Ateş Osman , Güler Meryem , Balcıoğlu Taylan
Published: December 2017

This study aimed to examine the effects of using a mouth guard in Karate on respiration parameters. The study sample consisted of 10 volunteer elite male karate athletes who participated in the National Karate Team and still practice the sport (24.4±6.3years, 176.2±7.4 cm, 71±4.1 kg). The athletes were exposed to respiration tests without and with mouth guard with 2 days interval that give FVC, FEV1, MVV and PEF values. In the light of the found parameters, were no meaningful differences were observed in measurements of parameters between the measurements with and without a mouth guard (p > 0.05).  The athletes continued their routine training between pre-test and post-test. In conclusion it was seen that the use of mouth guard did not directly affect the breathing performance.Extended English abstract is in the end of Full Text PDF (TURKISH) file.ÖzetBu çalışmada Karate sporundaki ağız koruyucusu kullanımının solunum parametrelerine etkisini incelemek amaçlanmıştır. Çalışmaya Karate Milli Takımı’nda yer almış ve aktif spor yaşantısı devam eden gönüllü 10 erkek elit karate sporcusu (24,4±6,3yıl, 176,2±7,4 cm, 71±4,1 kg) dahil edilmiştir. Sporcular FVC, FEV1 MVV, PEF değerlerinin elde edildiği solunum testlerine 2 gün ara ile dişliksiz ve dişlikli olarak katılmıştır. Kaydedilen parametreler ışığında,  dişlikli ve dişliksiz ölçümler arasında istatistiksel açıdan anlamlı bir ilişki gözlenmemiştir (p > 0.05). Sporcular ön test ve son test arası rutin antrenmanlarına devam etmiştir.  Sonuç olarak, dişlik kullanımının solunum performansını direkt olarak etkilemediği görülmüştür.
Association of of IL-1 receptor antagonist (IL-1RN) and interleukin-1β genes (IL-1β) polymorphisms with recurrent pregnancy loss in Iranian Azeri women
Authors: Ali Rahmani Seyyed , Paknejad Zeynab , Mohammadkhanlou Masoumeh , Daneshparvar Marina
Published: December 2017

Objective

One of the most important problems in human reproduction is recurrent pregnancy loss (RPL). RPL is defined as three or more consecutive abortions in the first trimester of pregnancy. The association between the polymorphisms in the immunological factors and RPL was investigated. The aim of our study was to determine the association of interleukin receptor antagonist (IL-IRN) and interleukin-1β (IL-1β) polymorphisms with RPL in Iranian Azeri women.

Materials and methods

The study participants consisted of 100 women with RPL of Iranian Azeri origin. The control group comprised 100 age- and ethnically-matched healthy women of the same reproductive age. Genomic DNA was extracted from the whole blood and genotype determinations were performed using polymerase chain reaction (PCR) amplification followed by restriction fragment length polymorphism (RFLP) analysis.

Results

Our results showed no significant relationship between IL-1RN polymorphism and RPL. The homozygous state in −857 C/T variant was seen to be higher in RPL patients than in control subjects. Also frequency of wild type genotype was lower in RPL patients than in controls. However, this associations was not significant.

Conclusion

This study suggested that −511 C/T (rs16944) and −31 C/T (rs1143627) polymorphisms in IL-1β gene may not be involved in RPL in Iranian Azeri women. Also the promoter polymorphism of the IL-1RN gene may not play a role in the susceptibility to RPL.
Influencia y repercusión mediática de los debates "cara a cara" celebrados ante las elecciones generales de 2008 en España: José Luis Rodríguez Zapatero (PSOE) vs Mariano Rajoy (PP)
Authors: Gallego Reguera María , Bernárdez Rodal Asunción
Published: December 2017

Este artículo se centra en el estudio de los debates electorales "cara a cara" celebrados en España con motivo de las elecciones generales de 2008 entre José Luis Rodríguez Zapatero (PSOE) y Mariano Rajoy (PP) y organizados por la Academia de las Ciencias y las Artes de Televisión. Se han seleccionado estos debates para su estudio en profundidad porque significan el retorno de los debates en España transcurridos quince años después los últimos cara a cara en unos comicios generales, los celebrados en 1993 entre el por entonces presidente del Gobierno, Felipe González (PSOE), y José María Aznar (PP). Los debates de 2008 se convirtieron en un suceso  histórico con una gran repercusión tanto en los medios nacionales como en los internacionales, que realizaron una relevante cobertura del mismo. Aunque la emisión de los debates apenas modificó el voto de los ciudadanos, sí incentivó la participación electoral, lo que siempre altera el reparto de escaños. Su celebración resultó importante para el proceso de la democracia, ya que motivaron la participación electoral, y para la información de los ciudadanos, quienes demostraron un gran interés por ambos programas políticos de televisión.