bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Development of An E-Voting Model for Village Head Elections Based on Android
Authors: Yanti Lestri , Wijaya Ardi , Apridiyansyah Yovi , Pahrizal Pahrizal
Published: August 2023

Voting or voting in a democratic country is an important part of the means of selecting leaders. Village head elections are generally still carried out conventionally, elections still use paper to elect village heads (Kades) which are carried out by punching one of the candidate images. The problem that arises is that voters must come to the polling place in order to be able to collect data and vote, for Citizens who cannot attend the polling place or do not exercise their right to vote will add to the data on the abstentions list that is present at the election. In village head elections (Pilkades) the vote counting process is still done manually so it takes quite a long time. This study aims to build an e-voting simulation system which is expected to provide knowledge of technological developments in the field of general elections. This system development method uses Waterfall. Furthermore, if you have obtained the results, you will test the system that was built by testing it with the black box testing method to see in terms of functionality all features are running smoothly or not. The results of testing the E-voting application for village head elections show that the system can run well and has been implemented so that it can be used on Android-based smartphone devices.
Information System Of Student Point Violations (Case Study Of Sma Muhammadiyah 7 Serbelawan)
Authors: Arrafiq Mhd Zhasnitra , Dewi Arie Rafika , Lubis Husni
Published: August 2023

Efforts to strengthen school discipline can be done in various ways. For example, at the middle school level, points for violations committed by students are calculated based on the rules set by the school. The number of fault points counted varies from warning to calling the parent at the highest level, and notifying the maximum number of fault points to the parent. SMA Muhammadiyah 7 serbelawan has issued a code of conduct. The school will apply penalty points for all infractions committed by students in an attempt to enforce disciplinary action. To improve teacher performance in dealing with problem students, the authors designed a system for calculating student violation points using the oriented objects technology method. By using the object oriented technology method, it will build a system systematically and regularly in order to achieve a goal based on the abstraction of existing objects and the presence of this system will certainly greatly help teacher performance, especially counseling guidance teachers and counseling guidance teachers, problems in recapitulating all student violations that occur in Muhammadiyah 7 Serbelawan High School. With a system that has been computerized and integrated with databases, it will be able to facilitate the process of finding student data that violates and conducting counseling easily and documents are stored neatly in the database.
The Relationship between Abdominal Muscle Strength and Jump Service Skills in Volleyball Extracurricular at SMKN 06 Mukomuko Regency
Authors: Pamungkas Baruno Tri , Mesterjon Mesterjon , Febrianti Mariska
Published: August 2023

This study aims to find out how the UAS questions in physical education lessons are made by sports teachers at SMP Negeri 3 Bengkulu Tengah. This research is a qualitative research. The subjects in this study were sports teachers who made UAS questions in class VII. The instruments in this research are content validity test instruments and construct validity tests. The results of the study show that the questions made by the sports teacher at SMP Negeri 3 in Central Bengkulu have not been said to be good. Because the teacher is not consistent in making questions for example in the content validity test. It says on the lattice that the questions contained in the indicators are 10 but in fact only 5 items are contained in the indicators, and it is also said on the lattice of questions that are contained in the indicators from No. 1-10 while in fact on the questions of No. 26 – 30 . on the items that are not contained in the lattice indicators totaling 25 items. Analysis of the questions on the construct validity test on the rules of writing a good question at No. 14 which contains each question must use language that is in accordance with the Indonesian language rules. In the problems analyzed, the researchers found that the writing of foreign language words was not italicized.
The Relationship between Arm Muscle Strength and Tosser Athletes in State High School Volleyball 13 Muko-Muko
Authors: Ahmad Deliah
Published: August 2023

This study aims to determine the scientific relationship between arm muscle strength and upper passing skills (Tosser) in volleyball. The formulation of the problem in this research is how big is the relationship between arm muscle strength and passing skills in volleyball games at SMA Negeri 13 Muko-Muko? This research was conducted at the Volleyball Development Club of SMA Negeri 13 Muko-Muko. The research method used is the correlation method with product moment statistics, this research is objective or what it is with a sample of 30 athletes assisted by the Volleyball Club of SMA Negeri 13 Muko-Muko taken with a total sampling technique. The results of the data Based on the results of research conducted at the Volleyball Club of SMA Negeri 13 Muko-Muko using the data normality test, homogeneity test, hypothesis testing, it can be concluded as follows: 1) Test results and measurement of arm muscle strength through push up tests on skills passing over a volleyball game is normally distributed, 2) Based on the results of tests that have been carried out that arm muscle strength has a significant relationship with passing skills in volleyball games
Analysis of the Difficulty in Performing the Volleyball Bottom Passing Technique at the Sahabat Muda Club
Authors: Afriyanti Amelia , Darsi Helvi , Sovensi Ever
Published: August 2023

This study aims to determine the difficulty of the underhand passing technique of the Sahabat Muda club in Lubuklinggau City and to determine the factors causing the difficulty of athletes doing the underpassing of the Sahabat Muda club in Lubuklinggau City. This research is a qualitative descriptive research that explains the situation or ongoing activities by conducting interviews. In this study, the population was 15 people and the sample consisted of 10 people who took part in volleyball training activities at the Young Friends Club. Data collection techniques using observation and interviews to determine the difficulties and factors of difficulty of each individual. The results of this study indicate that the description 1) The error that usually occurs when doing a downward pass is that the position of both arms is too high. When receiving the ball, both knees are not bent. The arms are not tight, the ball hits the upper arm. 2) The cause is due to an error in positioning the batting arm bent at the elbow so that the bat is narrow, as a result the ball rotates or turns its direction. Improper impact of the ball on the palm of the hand. At the time of contact with the ball the arms are not parallel. There is no harmonious or simultaneous movement of the arm and leg movements. Too explosive movement of the swing as a whole, so the ball is far off the mark. Knees are less bent in the preparation step of implementation. Hit or contact the ball with the forearm too late so that the direction of the ball is up and back. The high ball that should have been in the top pass, but was taken with the bottom pass, so it is not accurate at the intended target. Less able to regulate contact with the ball quickly, according to the arrival of the ball...
Extracurricular Basketball Shoot Lay-Up Ability Survey Of Students Of SMK Negeri 1 Bengkulu City
Authors: Pebrianto Fuji , Anggara Deffri , Apriansyah Dolly
Published: August 2023

This research is motivated by the game of basketball in schools, especially in high school, which is one of the game sports that is included in the curriculum as a compulsory sport to be taught. shoot on students of SMK Negeri 1 Bengkulu City. This type of research is qualitative research. The method used in this study is to use the lay up shoot technique. The subjects of this research were students of SMK Negeri 1 Bengkulu City. Data collection techniques are carried out in several ways, namely observation and documentation studies. The results showed that from the data from the lay-up shoot research conducted by students at SMK Negeri 1 Bengkulu City, there were 10 students in the very good category, 9 in the good category, 7 in the moderate category, 5 in the poor category, 0 in the very poor category. . The overall results obtained by all students of SMK Negeri 1 Bengkulu City were mostly in the Very Good category, 5 male students and 5 female students.
Application of the Hollow Sprint Method to the Results of the 100 Meter Run for Class X Students at SMAN 9 Seluma
Authors: Fitrawan Nozi , Perdima Feby Elra , Supriyanto Supriyanto
Published: August 2023

The purpose of this study was to determine the effect of the application of the hollow sprint method on the results of the 100 meter run in class X students at SMAN 9 Seluma. In this study, the research method used is the experimental method. The subjects of this study were students of class XA at ​​SMAN 9 Seluma as many as 32 students. Data collection techniques used in the research are test, observation and documentation methods. Analysis of the data used in quantitative research using the 100 meter running assessment guidelines. The conclusion of this research is the application of the effect of the application of the hollow sprint method has a significant influence on the results of the student's 100 meter run with the results of the t-test in the class studied both in the implementation of observations and the application of the hollow sprint method. The results of the observations obtained the value of t count or t count 11.41 > t table 1.695. And after the implementation of the holow sprint method, the results of the t test are t count or t count 16.95 > t table 1.695, so that the hypothesis which states that the application of the hollow sprint method has an effect on the results of the 100 meter run in class XA SMAN 9 Seluma is acceptable. the truth.
Metode Back Flushing Dalam Perhitungan Biaya Manufaktur
Authors: Ismanto Alek Candra
Published: August 2023

Penelitian ini berfokus pada metode backflush costing dan mekanisme pembuatan jurnal akuntansi, kemudian membandingkan metode tradisional dan backflush. Sisi positif dan negatif diungkapkan untuk menentukan apakah dapat dijalankan atau tidak untuk keadaan bisnis saat ini dan tergantung pada tujuan bisnis sehubungan dengan gaya manajemen yang diterapkan. Selain itu, metode backflush akan memicu perhitungan akuntansi manajemen modern yang secara tradisional hanya berfokus pada produk dan biaya yang melekat padanya. Backflush harus dikombinasikan dengan Just-In-Time untuk memaksimalkan keuntungan atau laba bagi bisnis. Dari pembuatan jurnal akuntansi yang menerapkan kedua metode tersebut, diharapkan dapat memahami tujuan metode Back Flush.
Perancangan Website Penjualan Kebutuhan Aksesoris Game Menggunakan CMS Prestashop
Authors: Muhammad Ridho  , Ina Sholihah Widiati  , Tinuk Agustin
Published: August 2023

With the current development of information technology, it adds new opportunities for actors kIt is activity buy and sell. at the same time the need for apparel gaming also increased with the development of technology. The increasing need for game accessories adds a new market share for online sales, because many consumers are lazy to come directly to physical stores. This makes the store must be able to compete for the market for game accessories through online sales.Design website e-commerce by using (Content Management System) CMS aims to see if the development is feasible to use likee-commerceanother. It takes an application that can be designed easily to be applied and understood as building a new online store.
Fibrotecoma Testicular: Tumor del Cordón Sexual Extremadamente Raro. Reporte de un Caso
Authors: López Balcarcel Stephanie Judith , Valdez Vargas Angel David , Tercero Cabrera Gustavo Ricardo , Barbales Irias Hugo Roberto , Ortiz Herrera Marco Antonio , González Reynoso Gustavo Eduardo
Published: August 2023

Introducción: Los tumores de tipo fibrotecoma son extremadamente raros, representan el 4 % de las neoplasias gonadales, derivan la túnica albugínea o del estroma gonadal y se asemeja al estroma ovárico, se consideran benignos. El tratamiento será la resección y será curativo si es una enfermedad localizada únicamente en gónadas. Objetivo: Presentar el caso clínico de un paciente masculino de 15 años con un tumor del estroma del cordón sexual de tipo fibrotecoma, características clínicas, exámenes de laboratorio,estudios de imágen y el manejo brindado. Métodos: Se evalúa paciente en consulta externa con evidencia de tumor testicular,se realizan estudios complementarios y se lleva a sala de operaciones realizando orquiectomía radical, la pieza es analizada histológicamente reportando fibrotecoma con cordón espermático libre de tumor. Paciente evoluciona adecuadamente, se da egreso y continua con seguimiento por el departamento de urología. Conclusiones: En pacientes masculinos, la neoplasia de tipo fibrotecoma es considerado poco frecuente y benigna, puede presentarse como tumoración de lento crecimiento o pubertad sexual precoz y si se diagnostica en etapa temprana, la resección será el tratamiento de elección y curativa. Se han reportado pocos casos a nivel mundial, por lo que el seguimiento del paciente se considera estricto.
Neutrosophic inverse power Lindley distribution: A modeling and application for bladder cancer patients
Authors:   Department of Statistics and Informatics, University of Mosul, Mosul, Iraq, Mustafa Marwah Yahya ,   Department of Statistics and Informatics, University of Mosul, Mosul, Iraq, Algamal Zakariya Yahya
Published: August 2023

The inverse power Lindley distribution is employed in the realm of survival analysis to imitate human lifetime data practices. The neutrosophic inverse power Lindley distribution (NIPLD) is intended to characterize a variety of survival data with indeterminacies. The established distribution is particularly useful for modeling uncertain data that is roughly positively skewed. This work discusses the key statistical properties of the developed NIPLD, including the neutrosophic survival function, neutrosophic hazard rate, and neutrosophic moments. In addition, the neutrosophic parameters are estimated using the well-known maximum likelihood estimation approach. To find out if the predicted neutrosophic parameters were reached, a simulation study is done. Not to mention, actual data has been utilized to discuss potential NIPLD real-world applications. Real data were used to illustrate how well the proposed model performed in compared to the current distributions.
Two-step synthesis and oxidizing power assessment of novel pyrylium
Authors: Wu Jingyun
Published: August 2023

Photoredox catalysis is a relatively new concept, and it involves the absorption of light for more productive use of lower energy radiation and to catalyze selective reactions. Traditionally, catalysts used for oxidation or reduction reactions were metal catalysts, such as iridium. However, these metal catalysts are not environmentally friendly and are expensive, prompting the use of organic catalysts. Pyrylium salt, an organic catalyst, can be used as a catalyst. However, the oxidizing ability of basic pyrylium is not that good and can still be improved. In this project, a pyrylium salt with substituents that include fluorine and chlorine (halogens) was synthesized to boost its oxidizing ability in an alcohol oxidation reaction due to its electron-withdrawing groups. Despite unsuccessful oxidation, there is still much research to prove that it can substitute for metal catalysts.
Bacteriostasis of bacillus sp. 22T against penicillium expansum and comparison between its ability on pear and grape
Authors: Su Zixun
Published: August 2023

In the biological lab of Zhejiang University, we justified and tested a type of bacillus to improve the anti-bacteria ability of commonly affecting diseases of fruits, such as pear and grape, which would lead to a large amount of economic loss and unpredictable negative influence if they were rotten before being sold. Using techniques such as gram staining and bacteriostasis test, this paper explores and confirms the results that bacillus sp. 22T has a strong ability to inhibit the growth of penicillium expansum on pear and grape. After 96 hours of exposure to fermentation broth containing bacillus sp. 22T to suppress the growth of penicillium expansum, 33.33 percent of pear and 16.66 percent of grape were not impacted by the bacterium.
A review of current developments in Alzheimers disease treatment methods
Authors: Xu Linfeng
Published: August 2023

This article will summarize the results of recent years of exploration into deeper causes of Alzheimers disease with possible therapeutic strategies. The most popular pathological hypothesis for the causation of Alzheimers is the A cascade hypothesis. A has a dominant role in the pathophysiology of Alzheimers disease, according to genetic and pathological data. Another significant histological characteristic of Alzheimers disease brains is the presence of neurofibrillary tangles made of the protein tau, which is related with microtubules. In the brain, neuronal loss, neuroinflammation, and oxidative stress can result from the cascade consequences of tau toxicity. But as research has progressed, it has been found the A. The accumulation of protein and neurofibrillary tangles composed of phosphorylated tau are only manifestations of AD, not the result. This is also the reason why many drugs fail the phase III clinic. So people began to look for a way out of the problem, starting in the direction of the gene. How to diagnose AD early in the MCI stage, how to find markers for early diagnosis and how to inhibit the progression from the MCI stage to the dementia stage are all questions that need to be investigated in the future.
Research on British epidemic forecastBased on SIR model
Authors: Zhang Chaoyu
Published: August 2023

Since the beginning of 2020, COVID-19 has swept the world and continues to threaten human society. Forecasting the future trend of the epidemics is very important for the prevention of COVID-19. The SIR model is an important mathematical model to forecast future epidemic in epidemiology. In a press conference from London on July 5th, British Prime Minister Boris Johnson said the British government will end nearly all of the coronavirus restrictions starting July 19. This paper aims to use the SIR model to predict epidemics after deregulation of social distance. The results show that as of July 8, 2021, the number of people infected will continue to increase after deregulation, reaching approximately 30000 per day. The British government should reconsider completely liberalizing epidemic control.
Principles and applications of fluorescent probe imaging technology
Authors: Li Jiayu
Published: August 2023

Fluorescent probe technology was discovered in the 19th century and imaging techniques were applied to microscopy around 1670. Fluorescence microscopic imaging is a classical method for observing the structure of organisms in the life sciences. In this regard, single-molecule fluorescence imaging uses fluorescent probes to label, detect, and analyze individual molecules, helping scientists to clearly observe the activities of individual molecules without disrupting the normal physiological state of the organism. In this paper, the principles and applications of fluorescent probe imaging techniques are described and analyzed. The common detection methods of fluorescent probes are spectrophotometry, electrochemistry, atomic absorption spectroscopy, high performance liquid chromatography, and fluorescence spectroscopy. Rapid detection results can be obtained depending on the specific method.
Efficacy and mechanism of cyclin-dependent kinase inhibitors against cancer
Authors: Pei Edwin H.Y.
Published: August 2023

This paper focuses on an overview of the development progress of different cyclin-dependent kinase (CDK) inhibitors. The CDKS are a group of kinases that are indispensable in the cell cycle. However, when it comes to cancer, the cell cycle is not healthy which causes malignancy of the cell that is able to mitosis infinitely. Considering the CDK are a group of molecules that is fundament during mitosis, researchers have developed its inhibitors to inhibit the effect that it has during the cell cycle to postpone the growth of cancer and lead to cancer cell apoptosis. This paper targets on the CDK inhibitors of pan-CDK, CDK4/6, 7, 9, and 12, also introducing their development history and current stages in clinical trials, as well as the drugs related to these CDK inhibitors that are FDA-approved for cancer treatment. In addition, the paper also introduces the future potentials of CDK inhibitors in the treatment and therapy of cancer-related diseases.
Eribulin and its application as anti-cancer treatment
Authors: Fan Yuhan
Published: August 2023

Eribulin (E7389) is a synthetic small molecule medication with high anti-cancer efficacy exhibited in preclinical studies. It is a structure-simplified macrocyclic ketone analog of Halichondrin B, which can inhibit the development of microtubule that is essential for the mitosis of cancer cells. The U.S. Food and Drug Administration (FDA) has given eribulin approval as a third-line chemotherapy for patients with metastatic breast cancer (approved in 2010) or metastatic liposarcoma (approved in 2016). In a number of clinical trials, eribulin has shown outstanding efficacy and safety in the treatment of solid tumors, particularly for breast cancer and sarcoma. Current eribulin clinical trials focus on its use in the therapy of other various cancer types, including non-small cell lung cancer (NSCLC), salivary gland cancer, cervical cancer, urethral cancer, and prostate cancer, and its application in combination treatment. The present study summarizes the mechanism, development, and future directions of eribulin, with an emphasis on the results of clinical trials.
Clinical efficacy of sodium dependent glucose transporters 2 inhibitor in the treatment of heart failure
Authors: Zhang Yuexiang
Published: August 2023

When it comes to diseases, heart failure is always an important issue for people around the whole world. Patients may suffer a lot when they have heart failure. Every year, there are a lot of people who dead because of having Heart Failure in and out of America. Nowadays, there are mainly two types of heart failures, HFrEF (heart failure reduced ejection fraction) and HFpEF (heart failure preserved ejection fraction). Research show that SGLT2 including Dapagliflozin, sotagliflozin, empagliflozin, and other types of inhibitors are effective when used to treat with heart failure patients regardless of whether they have had diseases like diabetes before. With the support of researches mentioned in the following passage, this idea will be reliable and we believe that with such kind of good news that the SGLT2 inhibitor are actually contributing to the process of dealing with HF, people who have been suffer from HF will one day be able to cured.
Immune escape mechanism of PD-1/PD-L1 in non-small-cell lung cancer(NSCLC) and its related drug treatment
Authors: Ye Hong
Published: August 2023

In recent years, a variety of treatment methods for Non-small cell lung cancer (NSCLC) have been used, but most of them fail to show significant effect due to the late stage of diagnosis. At present, immunotherapy has become a new way of tumor therapy and attracted wide attention, among which programmed death molecule-1(PD-1) and programmed death ligand-1(PD-L1) have been proved to relate to immune escape in NSCLC, and relevant clinical drugs have shown a clear therapeutic effect. The related drugs can relieve the immune tolerance by blocking the pathway, and play a role in tumor killing. There are now various related drugs. Here, I review the progresses of the mechanistic role of PD-1 pathway in the tumor immune escape and effect of related drugs therapy.
Liquid biopsy of circulating tumor DNA in cerebrospinal fluid for early diagnosis of brain malignancies: A review
Authors: Gong Liuxia
Published: August 2023

Brain cancer is the most aggressive intracranial disease: once diagnosed, 70% of patients will not survive. Early and accurate diagnosis is essential to improving the survival rate of diagnosed patients. Currently, imaging scans and pathological biopsies are mainly relied on to confirm the diagnosis of brain tumors. However, imaging scans do not confirm the diagnosis or tumor grade, nor do assess response and monitor treatment effect. Similarly, pathological biopsies are highly invasive and difficult to repeat. To address these limitations, the field has proposed the use of cerebrospinal fluid (CSF) as a liquid biopsy method to detect circulating tumor DNA (ctDNA). This review focuses on how liquid biopsy of CSF ctDNA can facilitate and complement the clinical care of patients with brain tumors. Relevant reviews in the past five years show that ctDNA is highly expressed and its content in CSF is higher than that in plasma. By sequencing the ctDNA of CSF, the diagnosis and prognosis information of brain tumors can be obtained, the best treatment method can be selected, the treatment response can be monitored, and the tumor evolution can be tracked. Because ctDNA detection is still in the research stage and lacks standardized technology, its effectiveness and practicality require further investigation before they can be used in clinical practice.
Analysis of the possibility of effectiveness that therapeutic techniques for diabetes in the treatment of heart failure
Authors: Huang Qingyi
Published: August 2023

Many studies have revealed that the recurrence of heart failure (HF) in patients with diabetes is significantly higher than that in patients without diabetes, and insulin resistance and abnormal glucose metabolism are common in patients with HF. Therefore, heart failure is an important clinical problem in diabetic patients. Diabetes and heart failure are "killers" that go hand in hand. They share common risk factors. Patients with heart failure frequently have hyperglycemia, and heart failure is a typical complication for diabetic patients. Based on the possible association between the two diseases, this paper will further analyze the therapies of type 2 diabetes (T2DM) and explore whether it can have an effect on how to address heart failure. The study's findings demonstrated that treating type 2 diabetes did have some influence on the management of heart failure and that treating type 2 diabetes did reduce the progression of heart failure symptoms.
CRISPR-Cas9 as a tool for treating cystic fibrosis through gene editing
Authors: Xu Jiabao
Published: August 2023

The most common cause of mortality is Cystic Fibrosis, a fatal genetic disease. However, in recent years, there have been a growing number of papers concentrating on CRISPR-Cas9, a gene-editing tool that is being used to permanently cure this genetic disease, named by a biopharmaceutical company EditasMedicine, invested in by Bill Gates. However, before the breadth of search and study of this technology continuously expands, challenges and remaining issues should be addressed. This paper reviews the mechanisms of cystic fibrosis and discusses its technical challenges, such as efficiency, safety and delivery of gene editing, potential side effects, and ethical issues, this paper also talks about the future applications of CRISPR-Cas9 in other diseases, so as to provide an alternative treatment method for the diseases with gene editing better results can be obtained.
Does oridonin inhibit the growth of small-cell lung cancer?
Authors: Lee Yu-Hsuan
Published: August 2023

Research Question: Can oridonin inhibit small cell lung cancer growth by blocking the Notch signalling? Purpose: Small cell lung cancer (SCLC) is an aggressive illness with a low 5-year survival rate. Oridonin is a Chinese medicine extracted from the leaves of the Rabdosia rubescens, a traditional Chinese medicinal herb, which has been proven to have many medical effects in opposition to the tumour. Notch signalling is an essential pathway in multicellular organisms and transfers information into living organisms. Methods: This study will use a human small-cell lung cancer cell line (H1688). Migration assay will test the influence of oridonin on cell migration. A Xenograft mouse tumour model is created to determine the effect of oridonin on tumour growth. Annexin V will test cell apoptosis, and a western blot is used to test whether Notch signalling is activated. All the assays are repeated three times, and the statistics are analyzed by calculating the means and doing the student's t-test. Possible results: There are three main possible results:(1) Oridonin can inhibit SCLC growth by blocking the notch signalling. (2) Oridonin can inhibit the tumour growth of SCLC cells but not by blocking notch signalling. (3) Oridonin cannot inhibit tumour growth but can block the notch signalling. Conclusion: The study will show whether oridonin can inhibit the growth of SCLC by blocking the notch signalling. It will provide a new method of treatment for those with SCLCs.
Correlation and enlightenment between type 2 diabetes and aging from the perspective of oxidative stress
Authors: Wang Kehao
Published: August 2023

Type 2 diabetes is a very common type in diabetes, which is also called noninsulin-dependent diabetes. This paper focuses on the correlation between type 2 diabetes (T2D) and aging from the perspective of oxidative stress (OS), including the pathway that T2D produces oxidative stress and the effect that oxidative stress imposes on T2D. This paper also mentioned some specific mechanisms, like a glycolytic pathway, enhanced formation of advanced glycation end products (AGE), activation of protein kinase C (PKC), and deactivation of the insulin signaling pathway. In addition, this paper also talks about the important influence of OS in the process of aging. And, the attention was focused on the excessive ROS produced by mitochondria. On this basis, this paper sorts out the correlation between aging and T2D in OS and finds some experimental evidence, through which this paper also offers some enlightenment from the way of anti-aging to anti-diabetes.
The role and efficacy of PROTAC in FLT3-mutated AML treatment
Authors: Liu Nicole
Published: August 2023

Small molecule Proteolysis Targeting Chimera (PROTAC) is an effective therapy for patients with FLT3-ITD acute myeloid leukemia (AML). By activating the ubiquitination system, PROTAC can generate protein and kinase degradation upon FLT3 to perform outcomes of antiproliferative activities. The focus of this study revolves around the investigation of the efficacy of VHL and CRBN-based PROTAC on FLT3 degradation compared to conventional immunotherapy agents such as quizartinib. By assessing the performances of PROTAC on MOLM-14 and MV4-11 cells with other therapies, comparing both adverse effects and benefits could demonstrate crucial approaches to applying PROTAC for AML treatments. The VHL-recruiting PROTAC based on the modification of quizartinib has shown promising effects where FLT3 within MV4-11 injected athymic mice had experienced around a 60% of decrease. The CRBN-based degrader TL12-186, on the other hand, had also demonstrated antiproliferative outcomes where 14 out of 7559 proteins of the MOLM-14 cell have been successfully degraded, showing a more than 25% decrease. Even though there seem to be some improvements in the VHL-recruiting PROTAC compared to traditional immunotherapy agents like quizartinib, CRBN-mediated PROTAC has shown a relatively less significant result. Critiquing in a variety of aspects, quizartinib has demonstrated better performance in cell permeability, low nanomolecular concentration, and degradation. The significance of this study provides an overview of existing PROTAC technology that shows effects on the treatment of FLT3-mutated AML. Further studies may be conducted on the foundation of this study to demonstrate the enhancements of each modified PROTAC compared to existing therapies.
Scientific facts on proteins when cooking
Authors: Wu Shuhuan
Published: August 2023

Protein is an essential part of food and makes a large contribution to the nutritional value of food. This paper evaluates protein by finding out the impact of different cooking methods on protein, and the influence of protein properties on the choice of cooking method. The results of this paper indicate that deep-frying maximizes the nutritional value of sturgeon. Cooking time and temperature have an impact on protein denaturation and nutritional value. Controlling heating time and temperature precisely can maximize retention of the color, flavor, and aroma of food. Using low-temperature vacuum cooking can reduce the loss of nutrients and moisture and also prevent secondary contamination. Different processes before cooking, such as basting, can not only increase the nutritional value but also enhance the flavor. The analysis can provide detailed information about the protein value and know what is the best way to cook sturgeon. It also provides a better understanding of the choice of cooking method and how to handle the food before cooking.
Research on the effects of gaming on the brain
Authors: Li Jialun
Published: August 2023

In recent decades, with the help of computer brain imaging technology and other advanced science and technology, a wealth of research achievements has been made in brain science related to games. These achievements explain the deep mechanism of games and provide scientific theoretical basis for the application of games. This paper analyses the effects of games on the brain. On the one hand, it focuses on the analysis and discussion of the positive effects on the brain in four aspects, including games make the brain excited, become more intelligent, improve agility skills, and improve observation. On the other hand, it summarizes the negative effects of excessive games on the brain, including the structural changes of the brain, mental malaise and brain stunting. In the end, the paper summarizes and summarizes the full text.
Brief classification and latest therapy for lactose intolerance
Authors: Shao Xiyue
Published: August 2023

Lactose intolerance is a digestive problem with a high incidence worldwide. The disease occurs mainly due to a lack or deficiency of lactase in the body, which prevents effective digestion of lactose. Congenital lactose intolerance is caused by a genetic defect that prevents the body from producing enough lactase, and its incidence is relatively low. Secondary lactose intolerance is caused by other gastrointestinal disorders, such as celiac disease, and is relatively common. Functional lactose intolerance is the most common form of lactose intolerance, in which lactase activity is reduced or lactose absorption is impaired, but there is no apparent organic disease. This article lists several possible solutions for different types of lactose intolerance based on the latest research. In studies of lactose intolerance, scientists have found that the rate of lactose intolerance varies widely across populations, with significant differences in prevalence by race and region. In addition, several studies have shown a link between lactose intolerance and the composition of the gut microbiome. Therefore, the study of lactose intolerance has important implications for understanding how the human digestive system works and the relationship between the gut microbiome and health.
ATAC-seq: A powerful tool for investigating chromatin accessibility and transcription factor binding
Authors: Wang Xilin
Published: August 2023

Chromatin Transposase Accessibility Sequencing is a new high-throughput sequencing technique developed by Professor William Greenleaf in 2013 which uses DNA transposase to probe chromatin accessibility with Tn5 transposase. This technique, which is simpler and more sensitive than DNase-seq, MNase-seq and FAIRE-seq and requires fewer cells, has been used to study chromatin accessibility using Tn5 transposase. ATAC-seq is important for the study of epigenetic molecular mechanisms because it can map chromatin accessibility on a genome-wide scale, compare open chromatin regions in different tumour samples, compare differences in transcription factor binding between treatments, reveal nucleosome localisation information and transcription factor binding sites, and can be used to locate specific unknown transcription factors, which can be used in combination with other methods to screen for specific transcription factors of interest. It is possible to combine this approach with others to investigate specific regulatory factors. Herein, ATAC-seq is systemically profiled to present that ATAC-seq has enormous potential to drive future discoveries in the field of genomics and beyond.
Global status of antibiotic resistance and management
Authors: Chan Lei
Published: August 2023

The greatest achievement of the 20th century is the invention and use of antibiotics. However, the abuse use of antibiotics caused by poor regulation has become an urgent issue worldwide, and has risen to be a threat to the global public health, bringing a great financial burden on society. From the perspective of the world, the United States has a long history of development in the discovery, application and regulatory process of antibiotics, forming sufficient cognition and relatively perfect countermeasures. Although the European Union and its member states started the measures to curb antibiotic resistance late, they also caught up and gradually established a complete monitoring system. As the largest developing country, China still has a lot to work on, especially the construction of basic medical facilities and systems. It can be seen that the importance of antibiotics use and management have become a global consensus. This article elaborated and focus the current situation of antibiotic resistance in the United States, the European Union and China as well as the corresponding countermeasures taken by each country. Countries should collaborate together and establish a global system to monitor the use of antibiotics in order to control antibiotic resistance.
Effectiveness of early cancer detection method: magnetic resonance imaging and X-ray technique
Authors: Zhang Cynthia Yueqiao
Published: August 2023

Cancer is a major problem plaguing human society today. With the research and development of nano-drug delivery technology and new non-surgical treatment methods, many types of early cancers can be cured or effectively controlled. However, the current treatment methods for advanced cancer are still limited, and efficient early cancer identification is crucial for enhancing patients prognosis and survival rates. Magnetic resonance imaging (MRI) and X-ray technologies are currently the mainstream and generally applicable means of early cancer detection. However, there is a lack of unified comparison and interpretation for their respective applicable cancer detection types. Herein, the paper first provides a comprehensive comparison and explanation of the working principles of the two technologies, as well as their advantages and disadvantages. Further, this article introduces the application of MRI and X-ray technology in the early detection of different common cancer types, including lung, breast, and brain cancers. The paper found that MRI is crucial in the early detection of brain cancer, and X-ray is a common method for lung cancer screening. With further advances in technology, cancer-related deaths can be further curbed.
Lysosomal proton pump: its role in SARS-CoV-2s egress and future therapeutic application
Authors: Chen Yuhan
Published: August 2023

The coronavirus SARS-CoV-2 is currently spreading throughout the world. The severity of the situation has increased efforts to create efficient prevention and treatment strategies. SARS-CoV-2 has been the subject of numerous experiments, and as a result, scientists now understand it better. Usually, the virus exits the cell through exocytosis. However, SARS-CoV-2 utilizes deacidified lysosomes as a means to egress from the infected cell.This proposal shows a deep understanding of lysosomal viral secretion and elaborates on the impact of the lysosomal proton pump, which functions to regulate the pH value of the endo-lysosomal environment, on lysosome functioning. Experiment are proposed to test the ability of a lysosomal proton pump inhibitor to impede the egress of the SARS-CoV-2 virus and analyze its potential application in a therapeutic target.
Future directions for management and treatment of algal blooms: A case study of filamentousCyanobacteria in Dianchi Lake
Authors: Wang Yifan
Published: August 2023

In March of each year, dormant spores of filamentous cyanobacteria (Aphanizomenon flosaquae) responsible for algal blooms in Dianchi Lake start to revive as the temperature reaches around 14 degrees Celsius. The apparent succession phenomenon between filamentous cyanobacteria and microcystis algae has made it one of the dominant species of eutrophication in Dianchi Lake. So far, China has invested more than 50 billion RMB in the treatment of eutrophication in Dianchi Lake, but the situation remains far from optimistic, with water quality only being classified as Class IV. To achieve sustainable development in Dianchi Lake water quality treatment and restoration, it is important to consider the economic value of the treatment products while implementing the remediation. Filamentous cyanobacteria, one of the main pollutants of eutrophication in water bodies, can be used to extract AFA-phycocyanin, which has been identified as a complex of C-phycocyanin/allophycocyanin, phycobiliproteins (including the chromophore phycoviolobilin), AFA-photosynthetic pigments, and mycosporine-like amino acids (MAA). These extracts can be used in nutritional cosmetics and pharmaceutical compositions for the prevention or treatment of diseases, disorders, or symptoms involving acute or chronic inflammation, oxidative denaturation of cellular or tissue, or uncontrolled cell proliferation. By extracting and processing filamentous cyanobacteria, its economic value can be increased, treatment costs can be reduced, and contributions can be made to the sustainable development of algal bloom pollution control in Dianchi Lake.
Synthesis of dihydrolucilactaene: a newly discoveredantimalarial compound
Authors: Wei Zijian , Gao Tian
Published: August 2023

The discovery of dihydrolucilactaene as a secondary metabolite in fungus Fusarium sp. RK97-94 showed a 100-fold increase in potency in antimalarial activity compared with its analoguelucilactaene. Although dihydrolucilactaene shows a high level of antimalarial activity and had been shown to be a promising drug lead candidate for malaria treatment due to its highly selective cytotoxicity towards malaria-causing pathogens and negligible cytotoxicity towards other cells at lower concentrations, its complete biosynthesis pathway in Fusarium sp. RK97-94 is still to be determined, making mass production of the molecule via biological means less than desirable. In this work, we propose a complete chemical synthesis route for dihydrolucilactaene via a series of reactions involving commercially available reagents for the potential industrial application and mass production of dihydrolucilactaene.
Different treatments for different types of gastric cancer
Authors: Sun Yumiao
Published: August 2023

Abnormal cell growth in the main part of the stomach is what usually leads to gastric cancer. 44% of newly diagnosed gastric cancer cases worldwide occur in China. Overall, gastric cancer is the fourth most common cancer and the second most common cause of cancer death. In recent years, some progress has been made in treating gastric cancer, and it has been found through research that hereditary gastric cancer does exist. The treatment options for gastric cancer will be analyzed and studied in this article. The various stages of gastric cancer will be introduced, along with the various treatment options based on the staging. Through research, early, middle, and late stages of gastric cancer can be distinguished. Early gastroscopy, a CT scan, positron emission tomography, local excision in the middle and late stages, chemotherapy, immunology, and medications for treatment are a few of the treatment options for gastric cancer. Different gastric cancers and patients use various diagnostic and therapeutic approaches depending on the type of cancer they have. Patients can better combat tumor cells and increase their five-year survival rate by using various diagnostic techniques for various time periods. Gastric cancer diagnostic research is anticipated to significantly lower the incidence of the disease with better early detection and chemoprevention for patients.
The influence of the nervous system on social behavior
Authors: Peng Jinhao
Published: August 2023

Social behavior plays an essential role in our daily life, not only in humans but also in other species, contacting with others through sociability can help organisms to contact with comrades and distinguish surrounding environments to survive well in different situations. This paper will focus on some techniques that are used widely in detecting neurons and the role of the nervous system in conducting animals' social behavior through mouse models to provide new ideas for the treatment of social disorders.
Seabirds in China in the face of industrial activities and oil spill: lessons learnt from Bohai Bay
Authors: Wei Zichen
Published: August 2023

Seabirds play essential roles in both terrestrial and marine ecosystems, but oil spill and habitat loss through reclamation and degradation have long been adversely affecting their populations worldwide, and thus affecting the well-being of terrestrial and marine ecosystems. In this study, using Bohai Bay in north China, a semi-closed continental sea where oil and gas activities and habitat loss are happening at a rapid pace as an example, threats for seabirds and their overlap with highly-risked areas in terms of an oil spill are reviewed. The results showed that while Bohai Bay is one of the most important sites for seabirds and waterbirds on the eastern China coast, oil spills and habitat loss are affecting the population of the birds. We concluded that sea birds in Bohai are at severe risks of oil spill and habitat loss, oil spill risks are especially high for autumn migrants, residents and winter birds, while habitat loss harms less ocean-dependent species. Accordingly, more focused and oriented efforts should be done in establishing conservation areas among Bohai Strait and the north side of the Shandong Peninsula and the western Bohai coast where overlap between bird diversity hotspots and potential exposure to habitat loss and oil spill occurs. And a general insight into how are given species affected by the two factors is given. This study enhances our understanding of seabirds vulnerabilities, what has been neglected, and what should be more well-noticed in future conservational endeavors.