bluuebunny/crossref_metadata_2025 huggingface dataset:
Spinal navigation for small thoracic intradural tumors: The challenge between minimally invasive and exoscopic magnification
Authors: Peron Stefano , Sicuri Giovanni Marco , Campione Alberto , Venturini Martina , Schembari Silvia , Rusconi Angelo , Cannizzaro Delia , Stefini Roberto
Published: August 2023

Background:

Spinal navigation offers significant benefits in the surgical treatment of small thoracic intradural tumors. It enables precise tumor localization without subjecting the patient to high radiation doses. In addition, it allows for a smaller skin incision, reduced muscle stripping, and limited bone removal, thereby minimizing the risk of iatrogenic instability, blood loss, postoperative pain, and enabling shorter hospital stays.

Case Description:

This video presents two cases demonstrating the application of spinal navigation technique for thoracic intradural tumors measuring <20 mm. In the first case, which involves a small calcified tumor, navigation can be performed using 3D fluoroscopy or computed tomography images obtained intraoperatively. Notably, as illustrated in the second case, the merging of preoperative magnetic resonance imaging images with intraoperative 3D fluoroscopy enables navigation in the context of soft intradural lesions as well. The setup of the operating room for these procedures is also depicted.

Conclusion:

In these procedures, the use of an exoscope, in addition to the well-known advantages in terms of magnification and ergonomics, provides a large space of movement around the surgical field, with greater ease in the use of navigation devices and ultrasound. The minimal invasiveness of the surgical approach is in no way a hindrance to exoscopic visualization and surgical dissection.
Makna Pantun Buah Janji dalam Tradisi Pernikahan Orang Jawant
Authors: Falentina Yustina
Published: August 2023

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan makna Patun Buah Janji. Penelitian ini menggunakan teori Interpretasi makna yang di kaji menggunakan makna leksikal yang terbagi menjadi 2 jenis yaitu: makna konseptual (langsung), dan makna asosiatif (kiasan) dan di analisis menggunakan teori interpretasi Paul Ricoeur yaitu hermeneutika, yang terbagi menjadi 3 tingkatan atau level yaitu: (1) level semantik, (2) level refleksi, (3) level eksistensial. Teknik pengumpulan data ini dengan cara observasi, dan wawancara.  Data diperoleh dari informan serta arsip atau dokumen. Hasil dari penelitian ini pantun tersebut bermaknakan menghubungkan antara manusia dan alam, dan manusia dan tradisinya, secara teoritis Pantun Buah Janji memiliki 2 pengertian yaitu langsung dan kiasan, level semantik mengkaitkan hubungan antara manusia dan alam, level refleksi menggambarkan antara manusia dan tuhan-nya, dan level eksistensial menghubungkan antara manusia dan hasratnya. Makna dari Pantun Buah Janji adalah sebagai bentuk pembelajaran yang dilakukan oleh guru kepada muridnya. Pantun ini juga merupakan pesan kepada para pengantin yang akan menempuh hidup baru setelah pernikahan adat tersebut selesai, pantun ini bertujuan memberikan kebutuhan secara rohani yang mempengaruhi pola hidup berumah tangga Orang Jawant dalam kehidupan sehari-harinya.
Tradisi Mandi Kembang Kaum Perempuan Di Desa Sungai Nipah Kecamatan Jongkat Kabupaten Mempawah
Authors: Prihantini Nur Kasih
Published: August 2023

Penelitan ini didasarkan oleh kepercayaan sebagian Masyarakat Melayu yang berada di Desa Sungai Nipah Kecamatan Jongkat Kabupaten Mempawah, adanya tradisi mandi kembang yang masih diyakini masyarakat lokal khususnya kaum  perempuan. Mandi kembang memiliki keterkaitan dengan konsep religi dimana ada ritual yang dilakukan untuk melakukan mandi kembang dan berlandaskan  kepada kepercayaan serta doa-doa yang ada pada sistem religi masyarakatnya. Tulisan ini bertujuan untuk mendeskripsikan motivasi kaum perempuan melakukan mandi kembang, bagaimana proses mandi kembang dan menganalisis makna yang terdapat pada media yang digunakan. Digunakannya teori ritual yang dikemukakan Turner yang berkaitan dengan makna mandi kembang. Penelitian ini menyimpulkan bahwa tradisi mandi kembang merupakan salah satu tradisi yang masih diyakini masyarakat sebagai salah satu bentuk usaha manusia untuk dapat dipermudahkan harapan yang diinginkannya.
Rediscovering the particle in a box: Machine learning regression analysis for hypothesis generation in physical chemistry lab
Authors: Thrall Elizabeth , Martinez Lopez Fernando , Egg Thomas , Lee Seung Eun , Schrier Joshua , Zhao Yijun
Published: August 2023

Given the growing prevalence of computational methods in chemistry, it is essential that undergraduate curricula introduce students to these approaches. One such area is the application of machine learning (ML) techniques to chemistry. Here we describe a new activity that applies ML regression analysis to the common physical chemistry laboratory experiment on the electronic absorption spectra of cyanine dyes. In the classic version of this experiment, students collect experimental spectra and interpret them using the Kuhn free electron model, based on the quantum mechanical particle-in-a-box (PIB). Our new computational activity has students train regression models of increasing complexity to predict the wavelength of maximum absorption for different cyanine dyes using a set of 13 molecular features. In addition, the activity introduces methods for evaluating and interpreting regression models. Ultimately, students are prompted to use their regression analysis results to generate hypotheses for what molecular properties underlie cyanine dye absorption, leading them naturally to the PIB model. In this report, we provide a dataset, reference code implementations in Mathematica and Python notebooks, and an example lab protocol with an introduction to cyanine dyes and the ML techniques. This activity can be completed in a single 3-hour lab period by upper-level undergraduate students with relatively little prior programming experience. Although intended to complement the experimental measurement of cyanine dye spectra, this activity can also be performed on its own; alternatively, it can form the basis of more involved projects in a computational chemistry or machine learning course.
Breaking the Access to Education Barrier: Enhancing HPLC Learning with Virtual Reality Digital Twins
Authors: Bin Abdullah Nazrul , Taylor Mae , Al-Dargazelli Ayah , Benito Montaner Mireia , Kareem Fatma , Locks Amy , Cao Zijing , Bowles Benjamin , Schafhauser Sophie , Sarraf Jean-Charles , Fajinmi Tamara , Muwaffak Zaid , Beckwith Cory , Parkinson Gary N. , Waller Zoe , Szulc Blanka R. , Hilton Stephen
Published: August 2023

This research focuses on an innovative approach to High Performance Liquid Chromatography (HPLC) practical teaching, specifically exploring the application of Virtual Reality (VR) digital twin models to revolutionize undergraduate education. Traditionally, the exposure to HPLC instrumentation for undergraduates has been severely limited due to the substantial student population and the prohibitively high costs of these systems. To surmount these constraints, we designed and developed custom in-house multi-user VR software and created a VR digital twin model of the HPLC instrument in a training environment containing multiple HPLCs, aiming to simulate a realistic, interactive, and immersive learning environment. The investigation included a group of undergraduates with no previous HPLC experience, assessing the effectiveness of the VR digital twin model juxtaposed with conventional teaching methods. Results exhibited a marked improvement in student comprehension of HPLC and their engagement levels, with the VR digital twin model serving as a significant enhancer. Notably, students reported a heightened confidence in their operational understanding of the instrument and exhibited a more profound grasp of the underlying theoretical concepts. In light of these findings, we propose that VR digital twin models can revolutionize practical teaching, particularly in areas constrained by equipment accessibility. This paper, therefore, offers compelling insights into the transformative potential of VR digital twin models in reshaping HPLC practical teaching in undergraduate education.
Proton-responsive ligands promote atmospheric CO2 capture and accelerate catalytic CO2/HCO2‒ interconversion
Authors: Barlow Jeffery M. , Gupta Nikita , Glusac Ksenija , Tiede David M. , Kaphan David M.
Published: August 2023

The synthesis and investigation of [Rh(DHMPE)2][BF4] (1) is reported. 1 features proton-responsive 1,2-bis(di(hydroxymethyl)phosphino)ethane (DHMPE) ligands, which readily capture CO2 from atmospheric sources upon deprotonation. The protonation state of the DHMPE ligand was observed to have a significant impact on the catalytic reactivity of 1 with CO2. Deprotonation and CO2 binding to 1 results in a ~10-fold rate enhancement in catalytic degenerate CO2 reduction with formate, monitored by 12C/13C isotope exchange between H12CO2- and 13CO2. Studies performed using a similar complex lacking hydroxyl ligand functionality ([Rh(DEPE)2][BF4] where DEPE = 1,2-bis(diethylphosphino)ethane) do not show the same rate enhancements when base is added. CO2 binding to 1 is proposed to facilitate pre-organization of formate/ CO2 in the transition state to lower the activation energy and increase the observed catalytic rate. Incorporation of proton-responsive DHMPE ligands not only permits CO2 capture from air, but also provides a unique approach to accelerate the kinetics of catalytic CO2 reduction to formate.
La crisis del concepto de capacidad en la legislación chilena: la protección internacional y autonomía de las personas con discapacidad intelectual
Authors: Lepin Molina Cristián
Published: August 2023

Este artículo tiene por objeto analizar la situación jurídica de las personas con discapacidad intelectual en el ordenamiento jurídico chileno, en especial, el marco normativo, el sistema o modelo adoptado por el legislador nacional, y la contradicción existente con los tratados internacionales que protegen los derechos de las personas con discapacidad. El trabajo pone de relieve la crisis en que se encuentra la noción de capacidad de ejercicio o de obrar, a partir de la aprobación de la Convención sobre los Derechos de las Personas con Discapacidad, especialmente por lo prescrito en su artículo 12, para luego revisar las limitaciones o barreras que la legislación civil establece, la manera en que se infringen las disposiciones internacionales y la posibilidad de establecer un sistema diferenciado de autonomía que reconozca las distintas capacidades de las personas y que establezca como una norma restrictiva y residual la incapacidad absoluta, solo para aquellos casos en que existe una privación absoluta de razón, y que coexista con los mecanismos de apoyo y salvaguardias exigidos por la normativa internacional.
Análisis de factores determinantes para permanecer en un trabajo que enferma
Authors: Silveira Padrón María Cecilia
Published: August 2023

El presente artículo analiza los factores que inciden en el mantenimiento de determinadas relaciones laborales, aun cuando causen daño manifiesto a la persona como trabajador. Partiendo de un recorrido teórico del concepto de trabajo, se conocen sus diferentes aspectos en los centros laborales contemporáneos, tomando como ambiente laboral los call center. Asimismo, se reflexiona sobre elementos clave de la dinámica laboral que afectan la salud física y mental de los trabajadores en sus diversos procesos sociales y psicológicos que refuerzan su apego a entornos laborales tóxicos, desde donde emergen diferentes enfoques de la organización del trabajo contemporáneo que necesitan ser replanteado para no ser nocivos a la integridad de la persona ni a la dinámica del propio ambiente laboral en su productividad.
Сучасний стан та тенденції розвитку ринку алкогольних напоїв в Україні
Authors: Зайченко Катерина Сергіївна , Болховська Анна Петрівна
Published: August 2023

У статті досліджено поточний стан вітчизняного ринку алкогольних напоїв, що є одним із найбільш пріоритетних для держави через низку причин: економічних, соціальних, культурних та ін. Проаналізовано нормативні акти, які регулюють виробництво та обіг алкогольних напоїв в Україні, зокрема Податковий кодекс та закони України, та останні зміни, що були ухвалені Верховною Радою України. Для визначення сучасного стану ринку алкогольних напоїв розглянуто динаміку його обсягів продажів та частки українських товарів на внутрішньому ринку в динаміці у період з 2010 до 2020 рр. Позитивна динаміка першого показника порівняно з негативною динамікою другого показника свідчить про зменшення ділової активності вітчизняних підприємств з таких причин: розвиток тіньового сектору виробництва алкогольної продукції, підвищення акцизів, зниження купівельної спроможності та ін. Визначено тип конкурентних відносин ринку алкогольних напоїв на основі ключових характеристик його функціонування: кількість продавців, еластичність попиту, контроль над ціноутворенням, методи конкуренції, бар’єри для входження на ринок. Проведений аналіз виявив, що на ринку діє значна кількість виробників та продавців товару; попит на продукцію є еластичним; існує державне регулювання, в тому числі і за рахунок встановлення мінімальних оптово-відпускних та роздрібних цін; застосовуються всі методи конкуренції як цінові, так і нецінові; є певні обмеження для підприємств при виході на ринок. Сформульовано основні тенденції розвитку ринку алкогольної продукції, які сформувалися під впливом факторів зовнішнього та внутрішнього середовища: переорієнтація українського споживача на продукцію вітчизняного виробника; преміумізація споживання алкогольних напоїв та підвищення рівня усвідомленості споживачів; диджиталізація; новий рівень домашнього споживання; зміна смаків споживачів та бажання нового в асортименті алкогольної продукції.
Цінова політика будівельно-виробничого підприємства та її вплив на конкурентоспроможність
Authors: Щербина Олег Сергійович
Published: August 2023

Сьогодення ставить підприємницьку діяльність в межі жорсткої конкурентної боротьби, котра стає визначальним фактором на шляху ціноутворення продукції будівельно-виробничих підприємств. Встановлення обґрунтованого рівня цін на ринку будівельних матеріалів є одним з основних об’єктивних факторів впливу на успішне планування роботи організацій, що включає прогнозування ефективності цінової політики та розуміння того, наскільки запланована система ціноутворення вирішуватиме можливість вдалого розвитку та протистояння конкурентній політиці. У статті представлена методика створення цінової політики будівельно-виробничих підприємств, встановлені основні цілі та завдання. Виявлено необхідність попередньої оцінки попиту на дану групу товарів для досягнення бажаного фінансового результату. В межах даного наукового дослідження представлено проєкт створення калькуляції будівельного матеріалу з урахуванням усіх складових собівартості продукції. Обґрунтовано важливість впливу ринкової політики конкурентів на ціноутворення власної номенклатури товарів. Розглянуті фактори і методи ціноутворення. Особливу увагу акцентовано на визначенні остаточної ціни на продукцію.
Сутність, моделі та етапи формування і реалізації державної політики у сфері культури в сучасній Україні
Authors: Гололобов Сергій Миколайович , Мірзоян Катерина Олександрівна
Published: August 2023

У статті здійснено теоретико-практичне висвітлення та удосконалення основних засад сутності, моделей та етапів формування і реалізації державної політики у сфері культури в сучасній Україні. Запропоновано концептуальну основу, що відображає сутність культурної політики у вигляді трирівневої моделі, яка розглядає культуру на мега-, макро- та мікрорівнях, у взаємозв’язку з природою (мегарівень), політикою та економікою (макрорівень) і людиною (мікрорівень). Розглянуто та охарактеризовано дві конфігурації моделей державної політики у сфері культури: 1) ліберальна, частково державна, державна бюрократично-просвітницька, державна престижно-просвітницька, національно-емансипаційна; 2) популістична, патерналістична, культуралістична, соціодинамічну. Доведено, що базовим критерієм вибору тієї або іншої моделі виступає значення та функції культури у суспільстві на конкретному етапі його розвитку. Обґрунтовано та запропоновано сучасній українській державі перейти до моделі відкритого доступу державної політики у сфері культури на основі партнерської взаємодії. Доведено, що для забезпечення переходу до моделі відкритого доступу необхідно реалізувати такі дві основні інституційні цілі як: 1) впровадити учасницьку модель урядування у сфері культури, що функціонуватиме на засадах відкритого доступу та сприятиме сталості сектора культури; 2) закріпити суспільно орієнтовану модель діяльності інституцій культури бюджетного та позабюджетного секторів. Розкрито поняття «суспільно орієнтовані інституції». Охарактеризовано такі 8 основних етапів формування та реалізації державної політики у сфері культури, як: 1) визначення проблеми; 2) формування «порядку денного»; 3) розробка варіантів вирішення проблеми; 4) вибір політики; 5) планування політики; 6) реалізація політики; 7) оцінювання політики; 8) перегляд політики. З’ясовано, що у сучасній Україні зазначеним вище етапам надається непропорційна увага: найбільше акцентується суспільна увага на етапі планування та етапі реалізації державної політики у сфері культури.
Potential of fermented kuini and ceri Terengganu beverages in enhancing insulin secretion in pancreatic cells
Authors: H. Hadijah , A.M. Musaalbakri , M. Syahida , J. Rosliza , M.A. Mohd Shukri
Published: August 2023

Kuini (Mangifera odorata) and ceri Terengganu (Lepisanthes fruticosa) are well-known indigenous fruit in Malaysia. Recently, the use of these fruits is gaining attention due to their high nutrient value. In this study, an antidiabetic activity was selected to be tested on the functional beverages from both fruits. A total of two products have been formulated based on the fermentation of kuini puree and ceri Terengganu juice. The study was conducted through an in vitro assay by using pancreatic cells (BRIN BD11). The pancreatic cells were incubated with KRB (negative control) or KRB-containing products (10-1000 μg/mL) or KRB containing glibenclamide (10-1000 μg/mL). Insulin concentration was determined using Rat INS (Insulin) ELISA Kit. Results showed that both fermented kuini and ceri Terengganu beverages have the ability to increase insulin secretion from BRIN BD11 cells as compared to the control. As for fermented ceri Terengganu beverage, the highest insulin secretion was observed at a concentration of 1000 µg/mL (3.51-fold of increment). Whereas for fermented kuini beverage, the highest insulin secretion was observed at a concentration of 500 µg/mL (3.38 -fold of increment). In conclusion, both fermented beverages have the potential to enhance insulin secretion from pancreatic cells. Further study is needed to be conducted through an in vivo experiment to verify the antidiabetic action of these fermented beverages.
Sosialisasi Pangan Aman dan Halal Pada Siswa Sekolah
Authors: Suyanto Agus , Nurrahman Nurrahman , Aminah Siti , Hersoelistyorini Wikanastri
Published: August 2023

Latar belakang: Pangan merupakan kebutuhan pokok manusia yang paling utama, yang tidak dapat ditinggalkan dalam kehidupan sehari-hari.  Tuntutan dan perhatian terhadap kualitas pangan yang akan dikonsumsi masyarakat, dirasakan semakin lama semakin besar. Pangan yang baik harus bermutu, bergizi, aman dan halal.  Tujuan: Kegiatan sosialisasi pangan aman dan halal untuk memberikan pengetahuan kepada siswa  akan pentingnya mengkonsumsi makanan yang aman dan halal. Metode: Sosialisasi ini dilakukan dengan cara memberikan pelatihan dalam bentuk ceramah kepada siswa  SMP dan SMK, masing-masing sebanyak 28 dan 23 orang. Pelatihan siswa SMP dan SMK dipisah agar lebih fokus dalam menerima materi. Untuk mengetahui dampak pelatihan dilakukan pre-test dan post-test dengan menjawab soal yang telah disiapkan.  Hasil: dari nilai rata-rata pengetahuan tentang pangan aman dan halal sebelum dan setelah ceramah sebesar 5,61 dan 7,04 untuk siswa SMP, sedangkan pada siswa SMK sebesar 5,35 dan 7,04. Kesimpulan: Sosialisasi menunjukkan bahwa tingkat pengetahuan siswa meningkat secara signifikan.
Kata kunci: halal, pangan aman, sosialisasi, siswa
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Abstract
Background: Food is the most basic human need, which cannot be left behind in everyday life. Demands and attention to the quality of food that will be consumed by the community, are felt to be getting bigger and bigger. Good food must be of good quality, nutritious, safe, and lawful. Objective: safe and halal food socialization activity to provide knowledge to students about the importance of consuming safe and halal food. Method: This socialization was carried out by providing training in the form of lectures to SMP and SMK students, totaling 28 and 23 students respectively. The training for SMP and SMK students is separated so that they are more focused on receiving the material. To find out the impact of the training, pre-test, and post-tests were carried out by answering the questions that had been prepared. Result: the average value of knowledge about safe and halal food before and after the lecture was 5.61 and 7.04 for junior high school students, while for vocational students it was 5.35 and 7.04. Conclusion: Socialization showed that the level of knowledge of students increased significantly.
Keywords: halal, safe-food, socialization, students
Design of Compact and Superdirective Metamaterial-Inspired Two- and Three-Elements Antenna Arrays
Authors: Dakhli Saber , Floc’h Jean Marie , Aseeri Mohammed , Mersani Ameni , Rmili Hatem
Published: August 2023

This paper presents the development of a miniature antenna array in a small space in order to achieve superdirectivity for long-range communication. The proposed structures consist of a superdirective metamaterial-inspired array based on a capacitively loaded loop (CLL) driven by an electrically small monopole antenna. This elementary antenna is then used in two- and three-array configurations separated by a fixed interelement distance of 0.1λ to achieve a higher directivity and compact size (with λ the wavelength calculated at the operation frequency 1.850 GHz). The design of the elementary antenna, its simulated radiation performances, as well as those of the parasitic array are also reported. The results of the optimization of two- and three-antenna arrays are discussed. For this study, three corresponding prototypes were fabricated and tested. The measured impedance mismatch and radiation pattern results are presented and shown to be in good agreement with their simulated values. The maximum measured directivity is equal to 5.9 dBi and 4.75 dBi in the case of the two- and three- elements, respectively. The proposed antenna arrays can serve for the realization of point-to-point wireless links and can have a significant impact on compact and high-directive radiofrequency front-ends of a wireless system and for wireless power transfer applications.
Metagenomic sequencing for investigation of a national keratoconjunctivitis outbreak, Israel, 2022
Authors: Motro Yair , Wajnsztajn Denise , Michael-Gayego Ayelet , Mathur Shubham , Marano Roberto BM , Salah Ikram , Rosenbluh Chaggai , Temper Violeta , Strahilevitz Jacob , Moran-Gilad Jacob
Published: August 2023

Background

Epidemics of keratoconjunctivitis may involve various aetiological agents. Microsporidia are an uncommon difficult-to-diagnose cause of such outbreaks.

Aim

During the third quarter of 2022, a keratoconjunctivitis outbreak was reported across Israel, related to common water exposure to the Sea of Galilee. We report a comprehensive diagnostic approach that identified Vittaforma corneae as the aetiology, serving as proof of concept for using real-time metagenomics for outbreak investigation.

Methods

Corneal scraping samples from a clinical case were subjected to standard microbiological testing. Samples were tested by calcofluor white staining and metagenomic short-read sequencing. We analysed the metagenome for taxonomical assignment and isolation of metagenome-assembled genome (MAG). Targets for a novel PCR were identified, and the assay was applied to clinical and environmental samples and confirmed by long-read metagenomic sequencing.

Results

Fluorescent microscopy was suggestive of microsporidiosis. The most abundant species (96.5%) on metagenomics analysis was V. corneae. Annotation of the MAG confirmed the species assignment. A unique PCR target in the microsporidian rRNA gene was identified and validated against the clinical sample. The assay and metagenomic sequencing confirmed V. corneae in an environmental sludge sample collected at the exposure site.

Conclusions

The real-time utilisation of metagenomics allowed species detection and development of diagnostic tools, which aided in outbreak source tracking and can be applied for future cases. Metagenomics allows a fully culture-independent investigation and is an important modality for public health microbiology.
Application of Bibliometric Visualization and Mind Mapping for Dadih Development
Authors: Mutia Sari Shinta , Amini Hijratun , Saraswati Lucia , Rozi Fachrur , Nazir Novizar , Azima Fauzan , Rahmayani Rahmayani
Published: August 2023

Beneficial lactic acid bacteria (LAB) are used to produce dadih, contributing to its health benefits. Dadih is fermented with lactic acid bacteria that convert lactose into glucose and galactose, enhancing digestibility. Despite its potential, dadih has limited appeal due to its traditional production methods and restricted market availability. To address this issue, the article suggests employing methodical concept development techniques, such as Mind Mapping, to generate innovative ideas for dadih product development. In addition, bibliometric analysis is used to obtain insight into the research trends and prospects in the field of food technology as they pertain to local fermented dadih products. The findings from the VOSviewer analysis reveal various aspects of dadih research, including mutagenicity, food safety, and fermented dairy products. Using these insights and mind-mapping techniques, this study advances dadih product development knowledge and is a foundation for future research.
Evaluating students’ ability in constructing scientific explanations on chemical phenomena
Authors: Laliyo Lukman Abdul Rauf , Utina Rahmat , Husain Rustam , Umar Masri Kudrat , Katili Muhammad Rifai , Panigoro Citra
Published: August 2023

Evaluation of students’ ability in constructing scientific explanations on scientific phenomena is essential as an effort to obtain information and feedback for innovation in learning process and curriculum development. Unfortunately, this issue is still left unexplored by researchers in chemistry education. Such is presumed to occur due to validated instruments, measurements, analysis techniques, and diverse epistemological values that leave much space to be investigated. Employing a Rasch model, we intended to validate test of ability in constructing scientific explanations on chemical phenomena, examine data fit with the Rasch model, evaluate difference in the students’ ability in constructing scientific explanations, investigate items with different functions, and diagnose causes for difference in item difficulty level. The respondents were 550 students from seven senior high schools in three regencies/cities and 153 university students in Sulawesi, Indonesia. Data were collected by 30 test items; each item consisted of three questions measuring students’ ability in proposing their knowledge (Q1), evidence (Q2), and reasoning (Q3). Their responses were assessed on criteria and analyzed using the Rasch partial credit model. This model applies an individual-centered statistical approach allowing researchers to measure up to item and individual level. Results suggested that data fit the Rasch model measurement. Also, students’ ability in constructing scientific explanations varied significantly. We found no items with different functions, signifying that sex and hometown do not influence students’ ability. However, based on item logit value grouping, it was discovered that item difficulty level also varied among students. This was particularly due to students’ lack of chemistry concepts mastery that lowered their ability and accuracy in constructing scientific explanation. This shows lack of epistemological engagement of students in learning process. In conclusion, this study provides valuable insights into students’ ability to construct scientific explanations and sheds light on factors that influence their performance in this area. Findings highlight need for targeted interventions that address students’ conceptual understanding and engagement with chemistry concepts, as well as promote critical thinking and scientific reasoning skills. This has important implications for science education and can inform curriculum development and evaluation policies.
Sonographic assessment of the common carotid artery luminal diameter in adults with co-existing diabetes mellitus and hypertension
Authors: Alhaji Modu Ali  , Anthony Chukwuka Ugwu  , Abubakar Shettima  , Umar Abubakar  , Onwuzu Sobechukwu W.I  , Mohammed Yusuf Mohammed
Published: August 2023

Background: Diabetes mellitus (DM) and hypertension (HTN) are known to cause major in changes in arterial morphology and function, (remodelling) including alterations in carotid intima media thickness (CIMT), carotid artery luminal diameter (CALD), and arterial compliance and blood flow velocity. However, there is a paucity of data evaluating common carotid luminal diameter (CCALD) in an adult with both DM and HTN (DM+HTN) in the study locality. Objective: This study is therefore aimed at evaluating the CCALD in adults with DM+HTN. Methodology: One hundred and fifteen (115) adult subjects with co-existing DM+HTN and one hundred and fourty four (144) healthy controls participated in the study. Their ages ranged from 18 to 80 years. The common carotid artery luminal diameter (CCALD) at the diastolic phase of the cardiac cycles was scanned and measured using a venue 50 ultrasound scanners with electronic calipers and high frequency linear array transducer. Result: The overall mean CCALD was 6.43±0.87 mm and 5.88±0.77 mm for subjects with DM+HTN and healthy controls, respectively. The mean CCALD value was significantly higher in subjects DM+HTN compared to the healthy controls (0.000). The mean CCALD correlated positively with age in males with DM+HTN hypertensive females, while no significant correlations were observed among healthy controls. Males had significantly higher mean CCALD value when compared to their female counterparts in both subjects with DM+HTN and healthy controls. Conclusion: In this study, the mean CCALD value in subjects with DM+HTN is significantly higher compared to those of healthy controls.
The impact of marketing mix on customer loyalty with customer satisfaction as mediating variable
Authors: Lena Ellitan
Published: August 2023

The drastic changes that have taken place in Indonesia have changed human lives. Humans who are already dependent on using plastic bags, should slowly reduce the use of plastic bags by the government. Due to government regulations, many companies that produce plastic bags and shops that sell plastic bags suffer losses. Therefore, plastic bag companies and shops that sell plastic bags must be clever in managing their marketing. This study was influenced by previous research that sought the effect of marketing mix (4P) on customer loyalty mediated by customer satisfaction. This research was conducted to understand the impact of marketing mix on customer loyalty in Surabaya, using customer satisfaction as a mediator. This research uses quantitative research methods, with 100 respondents aged 17 years or older, who have used plastic bags and lived in Surabaya. Respondents will fill in the questionnaire given using the Google form. This research found that the product has an impact on customer satisfaction; price has an impact on customer satisfaction; place has an impact on customer satisfaction; promotion has an impact on customer satisfaction; customer satisfaction has an impact on customer loyalty; customer satisfaction mediates the relationship between product and customer loyalty; customer satisfaction mediates the relationship between price and customer loyalty; customer satisfaction mediates the relationship between place and customer loyalty; customer satisfaction mediates the relationship between promotion and customer loyalty.
Klasifikasi Biji Kopi Berdasarkan Bentuk Menggunakan Image Processing dan K-NN
Authors: Fadjeri Akhmad
Published: August 2023

Temanggung Regency is the largest coffee producing area in Central Java. Robusta and Arabica are two types of coffee grown in this area. The manual method of sorting coffee beans is still used so the results are more subjective. Therefore, we require a system for categorizing coffee beans so that the results are more objective and reliable. This study uses K-NN classification and morphological features to recognize coffee beans based on the type and shape of the coffee bean defects. This aim of this study discovers which characteristics are better at classifying coffee beans into four categories (whole Robusta, whole Arabica, Robusta broken, and broken Arabica). A total of 110 coffee bean photos were used, with 80 images as training data, 40 images as test data, and a total of five morphological features.Our findings reveal that morphological traits may classify coffee beans into four categories with an accuracy of 62.5%, which is very good for detecting 100% whole Robusta and 90% Arabica but remains weak for recognizing broken coffee beans by type. Lean performs better in distinguishing coffee beans based on four classes, with a 70% accuracy. Morphological features outperform color features in distinguishing coffee beans based on shape defects, with an accuracy score of 83%.
Evils Full ofatē: Sophocles,Antigone1-6
Authors: Catrambone Marco
Published: August 2023

The article proposes two solutions for the textually controversial incipit of Sophocles’Antigone. In line 4, the corrupt οὔτ’ ἄτης ἄτερ can be emended to οὔτ’ ἄτης πλέων, an almost forgotten correction once tentatively proposed by Campbell. In lines 2-3, the syntax of Antigone’s question appears sound. Firstly, ὁποῖον οὐχὶ νῷν ἔτι ζώσαιν τελεῖ; in line 3 is a question governed by ἆρ’ οἶσθ’, with subject understood (Ζεύς). Secondly, ὅ τι Ζεὺς τῶν ἀπ’ Οἰδίπου κακῶν in line 2 is a pre-posed topicalised clause, with verb understood (τελεῖ or ἐστί), offering the background information from which the ὁποῖον-question takes its cue.
Ettore Romagnoli’s Horace in Black Orbace Rereading – with Digressions - the Bimillennial Conference
Authors: Sconza Federica
Published: August 2023

The paper investigates the Fascist exploitation of Horatian poetry by analysing the speech held by Ettore Romagnoli in 1935 on the bimillenary of the poet’s birth. Romagnoli’s oration must sacrifice to the demands of the oriented reading of Horace’s work promoted by the regime themes and attitudes characteristic of the poet (the reflections on time and the precariousness of human life, the search for self-sufficiency andaurea mediocritas, the rejection of dogmatism). Instead, the intellectual who moves from a secluded position to full adherence to the new Augustan establishment is exalted, at the cost of historical and literary distortions.
Soviet Cinema Music. The Second Generation – Composers of the Sixties
Authors: Egorova Tatiana Konstantinovna
Published: August 2023

The paper attempts to analyse the results of the activities undertaken by the generation of composers of the Sixties in cinema. The aim of the study is to identify the specifics of the Soviet school of cinema music, the core of which included the brightest and most extraordinary representatives of the Russian musical avant-garde who achieved fame and world recognition in various fields of academic and experimental music of the post-war period. The scientific novelty lies in understanding, both in each specific case and in general patterns, the degree of mutual influence of cinema, focused on the perception of the mass audience, on the one hand, and the manifestations of creative individuality of the composers, on the other hand. As a result of the study, the author comes to the conclusion that due to the effective creative activities of the composers of the sixties, the tradition of cooperation of Soviet cinematographers with the most talented and highly professional musicians was preserved for several years, which would not allow the Soviet school of cinema music to descend to the level of standardised narrative soundtrack.
Kemampuan Membuat Model Matematika dan Daya Juang Produktif Siswa SMP dalam Menyelesaikan Soal Pemecahan Masalah
Authors: Melani Rini , Herman Tatang , Hasanah Aan , Mefiana Syifa Ananda , Samosir Christina Monika
Published: August 2023

Membuat model matematika adalah kemampuan menerjemahkan situasi realitas ke dalam bahasa matematika. Model matematika sama dengan kemampuan representasi matematis. Ada tiga representasi matematika yang menjadi sorotan dalam penelitian ini yaitu konkrit, piktorial, dan abstrak. Penelitian ini dilaksanakan di salah satu sekolah di kabupaten Bandung Barat sejumlah 51 siswa. Peneliti memilih siswa berdasarkan tingkatan daya juang produktifnya yaitu tinggi, sedang dan rendah. Siswa yang memiliki daya juang produktif tinggi dapat menjawab ketiga soal dengan benar dengan model matematika abstrak. Siswa yang memiliki daya juang produktif yang sedang dapat menjawab dua soal dengan benar dengan model matematika konkrit dan abstrak. Siswa yang memiliki daya juang produktif yang rendah dapat menjawab satu soal dengan bantuan intervensi/perlakuan dari peneliti guna mendorong daya juang produktif dengan memberikan soal pemecahan masalah dan mengajukan pertanyaan gaya Socrates. Bantuan ini tidak menghilangkan kesempatan siswa untuk aktif berfikir, sebaliknya melalui metode ini siswa dituntut untuk memaknai pengetahuannya. Sebanyak 2% siswa mengerjakan soal dengan menggunakan model matematika konkret dan seluruh siswa yang mengerjakan dengan menggunakan model matematika konkret tersebut dapat menjawab soal dengan benar. Sebanyak 7.5% siswa mengerjakan soal dengan menggunakan model pictorial dan seluruh siswa yang mengerjakan dengan menggunakan model pictorial tersebut dapat menjawab soal dengan benar. Sebanyak 90.5% siswa memilih untuk mengerjakan soal dengan menggunakan model matematika abstrak. Hanya 12.5% siswa yang mampu mengerjakan soal dengan tepat. Sebanyak 78% siswa yang gagal diakibatkan mereka memilih menggunakan model matematika abstrak padahal mereka belum menguasai model matematika abstrak dengan baik.
Proses Berpikir Kreatif Siswa dalam Pengajuan Masalah Comprehending dengan Model Christou
Authors: Fi Umma Abika Sharah , Amir Mohammad Faizal
Published: August 2023

Penelitian ini bertujuan untuk mengidentifikasi proses berpikir kreatif siswa dalam pengajukan masalah comprehending dengan model Christou. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan studi kasus. Partisipan penelitian yaitu siswa kelas V A SDN Sidokepung II sebanyak 25 siswa. Pemilihan subjek penelitian menggunakan teknik purposive sampling. Pengambilan data meliputi tes pengajuan masalah comprehending model Christou dan wawancara. Teknik analisis data terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan. Indikator proses berpikir kreatif dalam pengajuan masalah terdiri dari tahapan persiapan, iluminasi, dan verifikasi. Hasil penelitian ini menunjukan bahwa proses berpikir kreatif siswa bervariasi pada setiap tahapannya bergantung pada comprehending siswa dalam mengajukan masalah. Penelitian ini menyarankan bagi guru sekolah dasar untuk menstimulasi kemampuan pengajuan masalah comprehending agar dapat membangun berpikir kreatif siswa.
What is the Role of Testosterone Therapy in Postmenopausal Women? A SWOT Analysis
Authors: Aktoz Fatih , Gunes Ali Can , Erel Cemal Tamer
Published: August 2023

Objective: The objective of this review is to examine the current state of evidence on postmenopausal testosterone use in women and explore its potential benefits and risks using the SWOT analysis method which is an evaluation system that allows reviewing any issue under the headings of strengths, weaknesses, opportunities and threats. Mechanism: Testosterone plays a role in female sexual physiology through its effects on the brain and peripheral tissues. At the central level, it stimulates regions of sexual function and interacts with specific receptors in the brain to regulate sexual desire, arousal, and satisfaction. At the peripheral level, testosterone affects various tissues and organs that are involved in sexual function, including the vagina, clitoris, and labia. Testosterone interacts with the androgen receptor in cells and triggers various physiological responses depending on the tissue. It stimulates sperm production in the testes, promotes bone growth and maintenance, and increases muscle mass and strength through protein synthesis. Testosterone also has a beneficial effect on bone density and the cardiovascular system, reducing the risk of heart disease and stroke. It influences cognitive functions such as memory, processing speed, and executive function through androgen receptor-regulated regions of the brain. Findings in Brief: Postmenopausal testosterone therapy may improve sexual function, muscle mass, and reduce the risk of osteoporosis. However, its long-term safety and effectiveness are still under debate. Testosterone therapy can be effective in treating certain symptoms in postmenopausal women, but it may also increase the risk of cardiovascular events and endometrial cancer, and can lead to adverse symptoms such as acne and hirsutism. Careful monitoring and regular hormone level checks are necessary to ensure safe and effective use. It’s important to consider the potential risks and benefits when deciding whether testosterone therapy is appropriate for a postmenopausal woman. Conclusions: Testosterone therapy in postmenopausal women may be a valuable treatment option for selected women. However, more research is needed to better understand the long-term effects of its use. Further research may also help to determine optimal dosing and route of administration, as well as specific testosterone preparations for women.
Integrating Red Blood Cell Features and Hemoglobin Levels in Metastatic Renal Cell Carcinoma Patients Treated with Pazopanib or Cabozantinib: An Easily Exploitable Prognostic Score
Authors: Mazzaschi Giulia , Lazzarin Alessandro , Santoni Matteo , Trentini Francesca , Giorgi Ugo De , Brighi Nicole , Tommasi Chiara , Puglisi Silvia , Caffo Orazio , Kinspergher Stefania , Mennitto Alessia , Cattrini Carlo , Verzoni Elena , Rametta Alessandro , Stellato Marco , Malgeri Andrea , Roviello Giandomenico , Silini Enrico Maria , Rescigno Pasquale , Rebuzzi Sara Elena , Fornarini Giuseppe , Quaini Federico , Giudice Giulia Claire , Banna Giuseppe Luigi , Buti Sebastiano
Published: August 2023

Background: The advent of immune checkpoint inhibitors (ICIs) has revolutionized the metastatic renal cell carcinoma (mRCC) therapeutic landscape. Nevertheless, tyrosine-kinase inhibitors (TKIs) targeting the vascular endothelial growth factor (VEGF) axis still play a key role. The aim of the present study was to explore the prognostic performance of an integrated blood score, based on hemoglobin (Hb) concentration, mean corpuscular volume (MCV), and red cell distribution width (RDW), in mRCC patients treated with anti-VEGF TKIs. The primary endpoint was to correlate Hb, MCV, and RDW with progression-free survival (PFS) and overall survival (OS). Materials and Methods: Our multicenter retrospective observational study involved mRCC patients treated with pazopanib or cabozantinib from January 2012 to December 2020 in nine Italian centers. Clinical records and laboratory data, including Hb levels, MCV, and RDW, were collected at baseline. Descriptive statistics and univariate and multivariate analyses were performed. Results: We enrolled 301 mRCC patients of which 179 (59%) underwent pazopanib, and 122 (41%) cabozantinib. We considered baseline Hb ≥12 g/dL, MCV >87 fL, and RDW ≤16% as good prognostic factors; hence, developing a multiparametric score capable of delineating 4 different categories. The number of good prognostic factors was associated with significantly longer PFS and OS (p < 0.001 for both). Therefore, we developed a red blood cell-based score by stratifying cases into two groups (2–3 versus 0–1, good factors). The impact on PFS and OS was even more striking (median PFS (mPFS): 16.3 vs 7.9 months; median OS (mOS): 33.7 vs 14.1 months)), regardless of the TKI agent. When challenged with univariate and multivariate analysis, the blood score maintained its high prognostic significance in terms of OS (multivariate analysis HR for OS: 0.53, 95% CI 0.39–0.75; p < 0.001, respectively), while the impact on PFS resulted in borderline significance. Conclusions: Our analyses demonstrate the prognostic role of a multiparametric score based on easily exploitable blood parameters, such as Hb concentration, MCV, and RDW. The red blood cell-based score may underlie the upregulation of the HIF-1α pathway and VEGF axis, thereby identifying a selected population who is likely to benefit from TKI therapy.
Which Came First, Age-Related Hearing Loss with Tinnitus or Cognitive Impairment? What are the Potential Pathways?
Authors: Ruan Qingwei , Chen Bing , Panza Francesco
Published: August 2023

Research on the causal relationship between age-related hearing loss (ARHL) and/or tinnitus and dementia is an important and fast-moving field. In this opinion paper, the up-to-date evidence and potential mechanisms for the bidirectional relationship are reviewed. We also present several critical factors that increase the challenges of understanding the causal relationship. These factors include common causes (such as aging, frailty, vascular impairment, and chronic inflammation), auditory and cognitive reserves, and the difficulty in distinguishing central auditory processing disorder (CAPD) from cognitive impairment. Finally, based on cumulative evidence, we propose an integrated mechanism in which the central auditory system might be the common target of both peripheral auditory impairment and dementia or its precursor. There is a bidirectional interaction between the peripheral and central auditory systems and between the central auditory systems and the cognitive brain. CAPD causes the depletion of auditory and cognitive reserves, and indirectly affects the peripheral auditory system via the auditory efferent system. According to the proposal, multimodal intervention might be beneficial for patients with ARHL and/or tinnitus and cognitive impairment, apart from hearing restoration by hearing aids or cochlear implants.