bluuebunny/crossref_metadata_2025 huggingface dataset:
Case report of holmes tremor and brief literature review
Authors: Martini Carolina Simão , Gonzaga Raphael , Pingarilho Alexandre , Franceschini Paulo Roberto , Dezena Roberto Alexandre , Aguiar Paulo Henrique Pires de
Published: January 2022

Introduction: Holmes Tremor is a slow frequency tremor, with an irregular presentation of rest and intention tremor, with postural component not obligatory. The Holmes tremor physiopathology, although not completely elucidated, can be explained by lesions in both basal ganglia-thalamo-cortical loop and cerebellum-thalamo cortical loop, and can be treated with a conservative approach– pharmacological treatment – or with surgery. It is reported a case that a surgery was elected as treatment, that resulted in a stimulation of the Ventralis Intermedius (Vim) and Zona Incerta (ZI). Case Presentation: Female patient, 41 years old, with Holmes Tremor involving both upper limbs, more predominant on the right side, and affecting more the proximal than the distal region of the limb. The tremor was both of rest and action, exacerbated by movement, anxiety, and stress. Due to functional impairment and failure of conservative neurological treatment with pharmacotherapy, a neurosurgical procedure was requested for implantation of two electrodes, targeting the Vim and ZI, on the left side for tremor control. Conclusion: Holmes Tremor is a complex syndrome and has its pathophysiology not so well elucidated. The case report describes an implantation of an electrode that had positive outcomes for the patient.
Management and pathophysiology of meningiomas during pregnancy. Literature review and case report
Authors: Bispo Breno Alexander , Aguiar Pedro Henrique Simm Pires de , Caso Ana Carolina , Pedreira Marianna de Souza , Crusius Marcelo Ughini , Aguiar Paulo Henrique Pires de , Carvalho Carla Muniz Pinto de , Bressan Filho Nelson Pedro
Published: January 2022

Introduction: Intracranial tumors diagnosed during pregnancy can cause complications and aggravation for both pregnant and the baby. Tumors are often confused with the diagnosis of eclampsia, therefore involve cautious analysis. Thus, characteristics such as high blood pressure, seizures, intracranial hypertension increase the level of severity of the tumors in question. Fast and efficient diagnosis is of paramount importance for the best outcomes in cases of intracranial tumors in pregnancy. Case Presentation: A 33-year-old primiparous patient G1P0A0, previously healthy, diagnosed with gestational hypertension, evolved during pregnancy with pre-eclampsia refractory to drug treatment. Computed tomography scan of the skull showed a giant sphenoid wing meningioma. At 38 weeks of gestation, the patient presented with a seizure and was admitted to the maternity ward, the examination of eye fundus showed edema of the papillae. In the week following delivery, the patient underwent craniectomy with total meningioma resection. Methods: We performed a literature review on Medline database using as keywords “meningiomas” and “pregnancy” to carry out our search, and 211 articles were found, with only 6 used in this paper, which were further compared with our case. Conclusion: Meningiomas diagnosed during pregnancy, although rare, require several precautions to preserve mother and baby’s lives. Furthermore, given the gestational period and hormonal changes, tumors undergo changes in their functional and anatomical characteristics. Treatment and diagnosis must be quick and efficient, taking into account the gestation time and tumor location.
Temporal correlations in the simplest measurement sequences
Authors: Vieira Lucas B. , Budroni Costantino
Published: January 2022

We investigate temporal correlations in the simplest measurement scenario, i.e., that of a physical system on which the same measurement is performed at different times, producing a sequence of dichotomic outcomes. The resource for generating such sequences is the internal dimension, or memory, of the system. We characterize the minimum memory requirements for sequences to be obtained deterministically, and numerically investigate the probabilistic behavior below this memory threshold, in both classical and quantum scenarios. A particular class of sequences is found to offer an upper-bound for all other sequences, which suggests a nontrivial universal upper-bound of 1/e for the classical probability of realization of any sequence below this memory threshold. We further present evidence that no such nontrivial bound exists in the quantum case.
Mídia Negra e Desigualdade na Estrutura Midiática: Apontamentos sobre Brasil e Estados Unidos
Authors: Da Silva Lopes Ivonete
Published: January 2022

O objetivo deste artigo é analisar a articulação entre racismo e políticas de comunicação (para promover ou restringir a diversidade racial) e o seu reflexo na organização dos sistemas midiáticos. A investigação se concentra no Brasil e Estados Unidos, países que possuem trajetórias bastante distintas na regulaçãoe promoção da diversidade racial na comunicação. No contexto norte-americano, houve leis explícitas que limitavam o acesso dos afro-americanos às concessões, contudo ações afirmativas foram implementadas para introduzir maior pluralidade no setor. No Brasil, por outro lado, não houve limitações formais, o que,no entanto, não implicou a redução da desigualdade na estrutura midiática. Nessa investigação adota-se como metodologia a análise documental (leis e relatórios) para mapear as políticas de comunicação e a participação da mídia negra nos sistemas midiáticos, e entrevistas com proprietários da mídia negra. Como principal resultado, a pesquisa revela que as políticas de ação afirmativa para empregar profissionais negros  promover maior diversidade racial nesse campo refletem-se, ainda hoje, em um cenário mais plural nos EUA se comparado ao brasileiro. O Brasil, com 56 % da população negra, possui 10 portais de notícias e uma revista, enquanto os Estados Unidos, com 14 % de afro-americanos na sua população, somam pouco mais de 500 mídias negras. Entretanto, nos dois países estudados evidencia-se a dificuldade de promoção da diversidade racial na comunicação, seja pelo obstáculo de avançar no debate e na criação dessas políticas, como o caso brasileiro, ou pelo retrocesso e descontinuidade da política de ação afirmativa verificado nos Estados Unidos.
Pengaruh kemampuan kerja dan motivasi kerja terhadap kinerja karyawan PT. Nusantara Card Semesta (NCS) cabang Jambi
Authors: Rachman Aditya , Adriani Zulfina , Kurniawan Dwi
Published: January 2022

This study aims to: determine the description of workability, work motivation, and employee performance of PT. Nusantara Card Semesta (NCS) Jambi branch. As well as to assess the effect of workability and work motivation of employees on the performance of employees of PT. Nusantara Card Semesta (NCS) Jambi Branch. Based on the study results that 1) Description of the workability of PT. Nusantara Card Semesta (NCS) Jambi branch with an average score of 106.5 is included in the very high category. The description of the average work motivation score of PT. Nusantara Card Semesta (NCS) Jambi Branch, 92.2, is included in the high class. Definition of employee performance of PT. Nusantara Card Semesta (NCS) Jambi Branch, with an average score of 99.1, is high. 2) Based on the results of multiple linear regression testing, the variables of workability and work motivation partially have a positive and significant effect on PT employees' performance. Nusantara Card Semesta (NCS) Jambi branch. Meanwhile, the variables of ability and work motivation also have a significant effect on PT employees' performance. Nusantara Card Semesta (NCS) Jambi branch.
Pengaruh persepsi keadilan kompensasi dan motivasi terhadap kinerja karyawan pada PT. Jambi Distribusindo Rayat
Authors: Oktaviani Aidel , Amin Shofia , Ratnawati Rts.
Published: January 2022

This study examines the effect of perceived fairness of compensation and motivation on employee performance. The sample of this research is 60 employees at PT. Jambi Distributionsdo Raya. The data collection method used a questionnaire and was measured by a Likert scale. The data testing technique used in this study includes instrument testing (validity test, reliability test), multiple linear regression analysis t-tests, F test, and coefficient of determination test (R2) with the help of SPSS application. Based on this research, it can be concluded that it partially shows that compensation fairness has a positive and significant effect on employee performance and motivation has a positive and significant impact on employee performance. Simultaneously, compensation justice and reason positively and significantly affect employee performance at PT. Jambi Distributionsdo Raya.
Pengaruh pengembangan sumber daya manusia dan kemampuan kerja terhadap kinerja karyawan PT. Jambi Media Grafika “Tribun Jambi”
Authors: Pramesrianto Adela , Amin Shofia , Ratnawati Rts.
Published: January 2022

This study aimed to determine whether the development of human resources and workability affects employee performance. The data used in this study are primary data obtained through interviews, questionnaires and processed with the help of SPSS 22 and Windows 10. The population in this study were all employees at PT. Jambi Media Grafika or Tribun Jambi and the sample amounted to 60 people. Research from the hypothesis proves that workability has a positive and significant effect on employee performance, but workability has no significant impact. This research implies that human resource development improves and enhances employee performance.
Analisis motivasi kerja pegawai Kantor Badan Perencanaan Pembangunan Daerah Kota Jambi
Authors: Juliansyah Dedi Ferry , Ardinal Ardinal , Sumarni Sumarni
Published: January 2022

Development. Planning Board of Jambi City. This study aims to determine how the work motivation of the Regional Development Planning Agency of Jambi City in terms of intrinsic and extrinsic motivation. The research methodology used in this research is a descriptive analysis using data collection method through questionnaire, documentation, literature study. Respondents in this research are employees of the Regional Development Planning Board of Jambi City. The results of this study indicate that the overall motivation of employees of the Development Planning Agency of Jambi City has been running quite well. The situation is indicated by the percentage of motivation factors that get the response from the employees. From this research, it can be concluded that the employees of the Regional Development Planning Agency of Jambi City are motivated to perform the tasks, although there are several obstacles. Based on this research, it can be mentioned several suggestions to the Development Planning Board of Jambi City to maintain and improve the motivation of their existing employees, enhance the system of Corporate Administration Policy and Supervision to the employees so that they can understand and perform their duties well.
Pengaruh konflik peran ganda (work family conflict) terhadap keberhasilan usaha (studi kasus pada Ikatan Pengusaha Muslimah Indonesia di Kota Jambi)
Authors: Widyasari Kiki , Dahmiri Dahmiri , Indrawijaya Sigit
Published: January 2022

This study aims to analyze the effect of multiple role conflicts on the business's success in the Jambi City IPEMI. This research was held at the IPEMI Gallery located on the Kambang River in Jambi City. The population in this study were Muslim women entrepreneurs who were members of the Jambi City IPEMI as many as 613 people. The sample in this study was 86 respondents using the probability sampling method, namely simple random sampling. The dependent variable in this study is multiple role conflict, and the independent variable is business success. This study shows that partially influencing considerable role conflict positively and significantly affects business success.
Corporate board and firm performance: A data envelopment analysis (DEA) of Italian listed companies
Authors: De Luca Francesco , Migliori Stefania , Muhammad Hussain , Rapposelli Agnese
Published: January 2022

This study aims to examine the effectiveness of corporate governance mechanisms by analysing the influence of corporate board structure on firm performance. A sample of 224 non-financial publicly traded Italian firms is selected to test the proposed research hypotheses and evaluate the firm’s efficiency by adopting a data envelopment analysis (DEA) approach. The findings show that corporate governance mechanisms are crucial in the performance of Italian publicly listed firms. The results show that the inclines and declines in DEA efficiency rankings are associated with the characteristics of the corporate boards. Additionally, many firms show a sub-optimal level of efficiency, as they do not operate at an optimal scale with respect to the efficiency frontier. This study represents an additional source of useful information for managers and stock investors because the DEA approach is a diagnostic tool for distinguishing between more and less efficient firms with respect to corporate governance mechanisms. This study contributes to the existing body of knowledge by providing a strategic framework to explore the board-performance relationship while applying the novel efficiency model
Live pig markets are hotspots for spread of African swine fever virus in Nigeria
Authors: Adedeji Adeyinka , Atai Rebecca , Gyang Helen E. , Gambo Panzam , Habib Maimuna A. , Weka R. , V.B. Muwanika , Masembe Charles , Luka Pam
Published: January 2022

Livestock trading through live animal markets are potential pathways for
the introduction and spread of economically important pathogens like the
African swine fever virus (ASFV) to new areas in several countries. Due
to the high demand for live pigs in Nigeria both for restocking and
slaughter, live pigs are sold at designated live pig markets (LPM) in
the country. This involves movement of pigs over long distances.
Despite, reports of ASF outbreaks following restocking of pigs bought
from LPMs, there is paucity of information on the role of LPMs in the
epidemiology of ASF. In this study, data and pig samples (whole blood,
sera, tissue) were collected from 4 selected LPMs in Nigeria (Dawaki,
Katsit, Numan & Pandam) between 2019 and 2020. Samples were analysed by
polymerase chain reaction (PCR) and Enzyme-linked Immunosorbent Assay
(ELISA). Four genes of ASFV positive samples were characterized to
identify the circulating genotypes. Results revealed trade activities
involving transportation of pigs from these selected markets to 42 major
cities and towns in thirteen (13) States of Nigeria. PCR results
revealed an overall ASF prevalence of 10.77% (66/613). ASFV was
confirmed by PCR in all the selected LPMs with a prevalence rate of
3.13%-23.81%. The phylogeny revealed genotype I and serogroup 4 based
on the p72 protein that encodes the B646L gene and the
EP402R gene encoding the CD2V. While sequence analysis of CVR of
B602L gene revealed 8 tetrameric repeats variants, six of which
have never been reported in Nigeria. Analysis of sera samples recorded a
seroprevalence of 6.9% (16/217) within the study period. Findings from
this study show that LPM are hotspots and channels for transmission and
continuous spread of ASFV in Nigeria. Therefore, for ASF to be
controlled in Nigeria, disease surveillance and regulation at LPMs are
critical.
Multi-objective Optimization, Process Scale-up Techno-Economics and Uncertainty analysis of Microwave-Assisted Extraction of Phenolic-Rich Extract from Allium sativum
Authors: Oke Olusola , Adeyi Oladayo , Okolo Bernerd , Okhale Samuel , Ude Chiamaka , Adeyi John , Otolorin John , Darlinton Nnabodo , Adeyanju James , Adeniyi adewale , Nwonsu-Obieogu Kenechi , Eleanyan Emmanuel
Published: January 2022

Allium sativum extract is one of the medicinal and aromatic products
used in pharmaceutical and food industries. The scientific literature
bibliography regarding process scale-up simulation and techno-economics
of phenolic extract from Allium sativum microwave-assisted extraction is
seldom reported. This study presented optimization and techno-economic
evaluation of phenolics recovery from allium sativum microwave-assisted
extraction. Box-benken design extraction experiment was conducted at
irradiation power (520 – 1040 W), extraction time (2- 10 minutes) and
solid-liquid ratio (0.4 – 1 g/100 ml). The extraction conditions that
optimized experimental extractible yield and Total Phenolic Content
(TPC) were evaluated in Box-benken desirability of Response Surface
Methodology. Bioactive finger printing of the extract was analyzed using
HPLC. Aspen Batch Process Developer was used for the process
techno-economic analysis. Profitability uncertainty was analyzed using
Monte-Carlo Simulation (MCS). Optimal extractible yield (28.62 %) and
TPC (76.8 mgGAE/g dry extract) were obtained at irradiation time 7.62
mins, microwave power 826.67 Watt with solid-liquid ratio 0.55g/100ml.
The HPLC fingerprint revealed Bentulinic acid, galic acid, chlorogenic
acid, ellagic acid and ferulic acid. Cost of Manufacturing (COM) for 5L,
50L and 500L extractors gave US$ 1480, US$ 220 and US$ 56
respectively. Techno-economic results of 500L extraction capacity with
900 kg/year design gave batch size (0.25 kg), production rate (2
kg/mins), cycle time (125 mins), discounted NPV (38133 US$), ROI
(34%), IRR (37%) and PBT (2.94yrs). MCS results show 85.58 % and
83.53certainties of achieving base case ROI PBT. Therefore, the study
shows that MAE of garlic powder is economically feasible.
Patriarchial ifos in the perception of Greek church chanters
Authors: Peno Vesna Sara
Published: January 2022

The paper deals with the so-called patriarchal - Constantinople ifos in the
recent church-singing tradition. Different aspects of this phenomenon are
presented, about which numerous stereotypical attitudes have been expressed
in different kind of narratives. In considering the phenomenon of ifos in
this study, we started from the fact that it was at the center of a dispute
between the reformers of the late Byzantine Neum notation - the so-called
the ?old method? and the conservative among Constantinople?s renowned
singers, who did not accept the ?new method? without resistance. It was also
stated that the patriarchal ifos by inertia and not always justifiably
attributed to the singers who were active in the Church of St. George on
Fanar. Also, arguments were presented in favor of a critical review of
contemporary discourses in which the ideologized belief is repeated that the
Constantinople throne is the guarantee of any kind of saint church
tradition, and thus the patristic Orthodox church music.
The magazine „Gusle“ (1911-1914) in the history of Serbian music periodicals
Authors: Vasic Aleksandar , Golubovic Marija
Published: January 2022

The Association of Serbian Singing Societies in Sombor started the magazine
?Gusle? in May 1911. It was a monthly magazine with each issue sixteen pages
long. In the introductory place in each issue ?Gusle? brought extensive
texts dedicated to the problems in the work of Serbian singing societies.
One column followed the work of the Association, and one brought news from
the life of singing societies. The magazine was concluded by notes and
advertisements. The out?break of the First World War stopped the publication
of this magazine. The last issue was published in April 1914. This is the
first study dedicated to the magazine ?Gusle?, its structure, content and
ideological profile. In the appendix, the paper brings an integral
bibliography of the journal, which did not exist until now.
Écoutant la musique de pan: Regarding the ontological horizons of 'Pause' in Claude Debussy’s Syrinx
Authors: Tomic Marija
Published: January 2022

The basic thesis of this paper is that 'pause' represents the ontological
center of Claude Debussy?s (1862-1918) Syrinx for solo flute (1913). The
phenomenon of the musical work is interpreted through an ontological
perspective, following Roman Ingarden?s reflections presented in his
Ontology of the Work of Art, having also in mind the different modes in
which music can exist, that can be read from Ferruccio Busoni?s Sketch of a
New Esthetic of Music. Since the programmatic content of Syrinx represents
the myth of Pan?s flute, we necessarily introduce Mircea Eliade's
explication of the phenomenon of myth, more precisely, of the mythical time,
into the theoretical discussion as well.
Musicians' attitudes towards concert activities in the first year of the pandemic: Belgrade context
Authors: Milanovic Biljana
Published: January 2022

This paper is based on the intersection of studies of performing arts, music
and digital media in the field of musicology, which I connected with
empirical research of professional musicians' attitudes towards Belgrade
concert life in art music in the first year of the coronavirus pandemic
(COVID-19). The research was conducted on the basis of a survey in which
fifteen concert musicians participated. Given the appropriate theoretical
perspective, the considerations are contextualized with respect to global
changes of concert life.
Predictors of response to BCG therapy in non-muscle invasive bladder cancer
Authors: Radovanovic Milan , Petrovic Milos , Santric Veljko , Zubelic Aleksa
Published: January 2022

Intravesical BCG (Bacillus Calmette?Guerin) therapy represents the therapy of choice for intermediaryand high-risk non-muscle invasive bladder cancers after transurethral resection. However, up to 40% of these patients do not show adequate response to the therapy (BCG failure) and 15% of them experience the progression of the disease to muscle-invasive bladder cancer. In such cases, radical cystectomy is indicated. Studies suggest that early radical cystectomy in patients with BCG failure is followed by better survival compared to delayed radical cystectomy. The prediction of response to BCG therapy could enable early identification of patients on which this therapy would have no effect and who should undergo early radical cystectomy.
Hypoglycemia Subtypes in Type 1 Diabetes: An Exploration of the Hypoglycemia Fear Survey-II
Authors: Maclean Rory H. , Jacob Peter , Choudhary Pratik , Heller Simon R. , Toschi Elena , Kariyawasam Dulmini , Brooks Augustin , Kendall Mike , Zoysa Nicole de , Gonder-Frederick Linda A. , Amiel Stephanie A.
Published: January 2022

Objectives: The Hypoglycemia Fear Survey II (HFS-II) is a
well-validated measure of fear of hypoglycemia in people with type 1
diabetes. The aim of this study was to
explore the relationships between hypoglycemia worries, behaviors, and
cognitive barriers to hypoglycemia avoidance and hypoglycemia awareness status,
severe hypoglycemia, and HbA1c.

Research design and
methods: Participants with
type 1 diabetes (n=178), enriched for people at risk of severe hypoglycemia (49%),
completed questionnaires assessing hypoglycemia fear (HFS-II), hyperglycemia
avoidance (HAS), diabetes distress (PAID), and cognitive barriers to
hypoglycemia avoidance (A2A). Exploratory factor analysis was applied to the
HFS-II. Clusters based on HFS-II, A2A, Gold, HAS and PAID were sought using
k-means clustering.

Results: Four HFS-II factors were identified: Sought
Safety, Restricted Activity, Ran High and Worry. Whilst Sought Safety,
Restricted Activity and Worry increased with progressively impaired awareness
and recurrent severe hypoglycemia, Ran High did not. Cluster analysis outlined
four clusters: two clusters with preserved hypoglycemia awareness were
differentiated by low fear / low cognitive barriers to hypoglycemia avoidance
(cluster 1), versus high fear and distress and increased Ran High
behaviors (cluster 2). Two clusters with impaired hypoglycemia awareness were
differentiated by low fear / high cognitive barriers (cluster 3), and high fear
/ low cognitive barriers (cluster 4).

Conclusion: This is the first study to define clusters of
hypoglycemia experience by worry, behaviors, and cognitive barriers to
hypoglycemia avoidance. The resulting subtypes may be important in
understanding and treating problematic hypoglycemia.
Three Sides to the Story: Adherence Trajectories During the First Year of Sodium–Glucose Cotransporter 2 Inhibitor Therapy Among Medicare Beneficiaries
Authors: Hawley Chelsea E. , Lauffenburger Julie C. , Paik Julie M. , Wexler Deborah J. , Kim Seoyoung C. , Patorno Elisabetta
Published: January 2022

Objective We aimed to understand the factors associated with SGLT2i
adherence and longitudinal adherence trajectories in older adults with type
2 diabetes.

Research
Design and Methods Using Medicare claims data (April
2013-December 2017), we identified 83,675 new SGLT2i users aged ≥66 years old
with type 2 diabetes. We measured SGLT2i
adherence as the Proportion of Days Covered (PDC) during the first year
of SGLT2i therapy. We used linear regression to assess the association between
baseline covariates and PDC. Then we used group-based trajectory
modeling to identify distinct longitudinal SGLT2i adherence groups and used a
multivariable logistic regression model to examine the association between
baseline covariates and membership in these adherence groups.

Results Unadjusted mean PDC was 63%.
Previous adherence to statins had the strongest positive association with PDC [regression
coefficient 6.00% (95% CI, 5.50%,6.50%)], whereas female sex [-5.51% (-6.02%, -5.00%)],
and Black race/ethnicity [-5.06% (-6.03%, -4.09%)] had the strongest negative
association. We identified three
adherence trajectory groups: low (23% of patients, mean PDC: 17%), moderate
(32%, mean PDC: 50%), or high adherence (45%, mean PDC 96%). More patients
in the high adherence group were
previously adherent to statins [OR 1.43 (95% CI 1.39,1.48)], and more women
[1.28 (1.23,1.32)] and Black patients [1.31 (1.23,1.40)] were in the low adherence group.

Conclusions
In
a large population of older patients with type 2 diabetes, 45% were highly adherent
during the first year of SGLT2i treatment. Female sex and Black race/ethnicity were most strongly associated
with low adherence.
Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting β-Catenin Degradation in Type 1 Diabetic Mice
Authors: Chen Xiaoqing , Li Yilang , Yuan Xun , Yuan Wenchang , Li Conglin , Zeng Yue , Lian Yuling , Qiu Xiaoxia , Qin Yuan , Zhang Guiping , Liu Xia-Wen , Luo Chengfeng , Luo Jiandong , Hou Ning
Published: January 2022

Methazolamide
(MTZ), a carbonic anhydrase inhibitor, has been shown to inhibit cardiomyocyte
hypertrophy and exert a hypoglycemic effect in patients with type 2 diabetes
mellitus and diabetic db/db mice. However, whether MTZ has a cardioprotective
effect in the setting of diabetic cardiomyopathy is not clear. We investigated
the effects of MTZ in a mouse model of streptozotocin-induced type 1 diabetes mellitus
(T1DM). Diabetic mice received MTZ by
intragastric gavage (10, 25, or 50 mg/kg; daily for 16 weeks). In the diabetic
group, MTZ significantly reduced both random and fasting blood glucose levels and
improved glucose tolerance in a dose-dependent manner. MTZ ameliorated
T1DM-induced changes in cardiac morphology and dysfunction. Mechanistic analysis
revealed that MTZ blunted T1DM-induced enhanced expression of β-catenin. Similar results were observed in neonatal rat cardiomyocytes (NRCMs) and adult mouse cardiomyocytes treated
with high glucose or Wnt3a (a β-catenin activator). There was no
significant change in β-catenin mRNA levels in cardiac tissues or NRCMs. MTZ-mediated
β-catenin downregulation was recovered by MG132, a proteasome inhibitor. Immunoprecipitation
and immunofluorescence analyses showed augmentation of AXIN1–β-catenin interaction
by MTZ in T1DM hearts and in NRCMs treated with Wnt3a; thus, MTZ may potentiate
AXIN1–β-catenin linkage to increase β-catenin degradation. Overall, MTZ may alleviate
cardiac hypertrophy by mediating AXIN1–β-catenin interaction to promote degradation
and inhibition of β-catenin activity. These findings may help inform novel therapeutic
strategy to prevent heart failure in patients with diabetes mellitus.
STEAM-APPROACH IN THE CONTENT OF THE HOBBY GROUP WORK TECHNICAL CREATIVITY
Authors: Shevchenko Oleksandr
Published: January 2022

STEAM is actively implemented in the modern educational space of Ukraine. This is due to the fact that one of the important tasks of education is the comprehensive development of the growing generation, their acquisition of the necessary competencies and successful realization in the future. Therefore, the required condition is the formation of an integral (coherent) approach to the content of education and the formation of the educational environment. Analysis of theory and practice shows that the STEAM-approach contributes to the improvement of the learning process in the educational institutions, including after-school education, based on the use of five components: Science, Technology, Engineering, Arts, Mathematics It has been established that steam aims to expand opportunities and areas of work, promoting not only the development of the subject competencies in the field of natural sciences, technologies, engineering, art and mathematics, but also the key competencies that are set to ensure effective child socialization and actively interact with each other. At the heart of large-scale multi-year research, such scientists as N. Balyk, G. Shmyger, Ya. Bykovskyi, N. Polihun, J. Bilyk, V. Zhukova, V. Pikalova, A. David, etc., came to the unanimous conclusion that these components are of great importance in the development of science and society in the future. They are also called disciplines of the 21st century. In the future, they may become the basis for such professions as: chemical engineers, software developers, petroleum engineers, computer systems analysts, mechanical engineers, civil engineers, robotics mechanics, nuclear medicine engineers, architects of underwater structures and aerospace engineers. Special attention in the article is focused on the question of STEAM -approach in the content of the hobby group work on technical creativity.
WORD-FORMATING AND SEMANTIC CHARACTERISTICS ENGLISH METHODOLOGICAL VOCABULARY
Authors: Tsymbal Yulia
Published: January 2022

In this article the morphological term creation is analyzed: affixation, conversion, general vocabulary processes and lexical-semantic relations in the English term system of education are also analyzed. The English-speaking terminology system of education is characterized as complex, stable and dynamic. Its elements are units of autochthonous language and borrowing from other languages, and the structure is isomorphic to the structure of logical connections between the concepts of the field of education. This term system is an open set, which draws from the whole variety of language tools new opportunities for expressing the values arising in the process of further development of educational activity. Semantic terminology has always been one of the main ways to replenish terminology. As a result of the semantic method of terminology, the terminological meaning is exhausted on the rights of the lexical-semantic variant, which develops on the basis of the adjacency of the signs of what is already indicated in the previous meaning of the word and the new one, which is denoted.
FIELDS AND LIMITS OF ECONOMIC HUMANISM
Authors: Kosovych Vitaliy , Kosovych Bohdanna
Published: January 2022

The article is devoted to the search for formal criteria of economic humanization in the new millennium. The fields and limits of a human-oriented economy are defined as such criteria. Fields of economic humanization are considered as a system of economic relations in which socio-economic human rights are realized. As the results of comparative analysis, it is established that the list of socio-economic human rights is characterized by constant development. The set of these rights is most clearly outlined today in the Sustainable Development Goals. It is emphasized that due to a set of preconditions of objective nature (political, economic, biological, natural-ecological) humanization processes in the economy must be reasonable and rational, i.e. in some way limited. The limits of economic humanization are interpreted as restrictions on human-centered evolution of the modern economy caused by the need for sustainable economic development. It is argued that the principle of parity and proportionality between the factors of economic development and the factors of economic humanization should be the basis of economic humanism. It is proposed to take into account international and national factors in the formation of fields and limits of economic humanization. Attention is drawn to the need for a conduct of a separate study of state and legal regulation of fields and limits of economic humanization, in particular in entrepreneurship.
THE MODERN VIEW OF PHYSICAL THERAPY ON RECOVERY OF PATIENTS AFTER STROKE WITH UPPER LIMB SPASTITY
Authors: Homola Alona
Published: January 2022

The purpose of the article is to analyze recommendations for physical therapy methods after acute cerebrovascular accident. Most often, complications of the function of the upper limb occur, this causes difficulties in everyday and professional life. In most cases, the function in the arm is restored worse than in the leg. In case of insufficient restoration of hand function, an occupational therapist teaches the patient the basic skills of self-care: eating, bathing, personal toilet, dressing, controlling bowel movements and urination, using the toilet, moving around, the ability to move on a flat surface, climbing stairs. There are many technical devices that allow you to be independent: an anti-slip mat, prevention of falling in the bathroom, handrails, a step into the bathtub, seats in the bathtub, etc. In the first month of the recovery period, people after a stroke develop complications – contractures of the affected limbs, pain and pulling sensations; spasticity develops, which impairs coordination and balance and, as a result, increases dependence on others. Spasticity increases unevenly, the patient develops a peculiar Wernicke-Mann posture: the upper limb is bent at the elbow and radial wrist joints, the fingers are clenched into a fist; the lower limb is straightened at the hip, knee and ankle joints. Unqualified recommendations and improper selection of a physical therapy program provoke an increase in spasticity. Objective. To find effective evidence-based physical therapy methods that affect the restoration of upper limb function. Methods. Scientific literature analysis, synthesis, generalization, pedagogical observation. An important question for a physical therapist is the selection of effective methods that positively affect the restoration of functional movement of the upper limb, the patient receives an achievable request, and the specialist is able to prevent negative consequences and get good results in a short time.
HUMAN FACTORS: THE PROBLEM OF MAN-MACHINE INTERACTION UNDER THE DIGITALIZATION CONDITIONS
Authors: Protasenko Olga , Mygal Galyna
Published: January 2022

The main attribute of a modern labour paradigm is a new type of man-machine interaction – the digital ecosystem. However, despite the improvement of man-machine interaction, the human factor remains the most difficult issue in ensuring the safety of such systems. Moreover, the digitalization process complicated the problem of the human factors because it led to a decline of the human’s subjective responsibility for the actions performed because of a significant increase in the share of artificial intelligence in decision-making. As a result, the number of accidents in recent years has decreased but insignificantly. In most cases, the research methods of the human factor are focused on environmental and technical problems of the system functioning, leaving a human unattended. In this regard, the research aims at the peculiarities of human activity in the digital ecosystem. The research was carried out in two directions. The first one is the study of human needs in the digital ecosystem, due to which it was established that a person needs digital safety. This need determined the emergence of a new phenomenon – the safety culture in the digital space. The second direction is the study of the person’s resources. The study of this issue showed that the “cycle” of resources and, in particular, its balanced affects the manifestation of the “human factors” phenomenon.
THE GOLDEN AGE OF DETECTIVE FICTION: GENRE CONVENTIONS OF AGATHA CHRISTIE’S COSY MYSTERIES
Authors: Ramazan Farman J.
Published: January 2022

The article focuses on the investigation of detective fiction in general and detective stories in particular which in this research is understood as a narrative where the plot hinges on a crime that the characters investigate and attempt to solve. The research also deals with various genre types of detective stories, such as police-department procedurals, hardboiled, locked room mysteries, cosy mysteries. Special attention is paid to the genre development of detective stories from a historical perspective. It is worth underlining that the period between World War I and World War II (the 1920s and 1930s) is generally referred to as the Golden Age of Detective Fiction. The purpose of the study is to highlight the main plot elements of a cosy mystery, such as the protagonist, the antagonist, the setting, the crime event, and definite narrative mechanisms involved in a story.
DISTANCE TECHNOLOGIES IN THE PROCESS OF FORMING THE ENGLISH-LANGUAGE COMPETENCE OF FUTURE ENGINEERS
Authors: Halatsyn Kateryna , Feshchuk Alla
Published: January 2022

The urgency of forming English-speaking competence through distance technologies is caused by modern requirements of training specialists in the technical sphere and epidemiological situation in the world. The article aims to define the essence of English-speaking competence formation through distance technologies. In order to realise the defined goal, it is essential to solve the following tasks: 1) to substantiate the essence of the process of formation of English-speaking competence with application of distance technologies; 2) to analyse the specificity of formation of English-speaking competence of future engineers in the course of the use of distance technologies at English lessons. Distance technologies of developing English-speaking competence of future engineers are considered as a set of forms and methods aimed at forming and improving the competence of reading, translation, listening of authentic audio texts, video texts, scientific articles; improving the competence of English-speaking written speech; systematisation of English-speaking grammar competence through tests with the help of distance platforms and Internet-resources. It was found that English-language professional competence integrates knowledge of professional terminological vocabulary, skills of working with English-language professional texts and documents, and background knowledge of socio-cultural features of the language under study. The author proposes goals for the use of distance learning technologies in the course “Academic English”.
MYTHOLOGICAL, RELIGIOUS AND PHILOSOPHICAL WORLDVIEW DOMINANTS IN NOTARY ACTIVITY
Authors: Manoylo Nataliia
Published: January 2022

The notary system occupies a prominent place in any democratic and legal society. Proper performance of functions largely depends on the high level of professional qualification of notaries. The latter is achieved by what values dominate in their operational consciousness. With this in mind, the article considers the main types of worldview in their value manifestations in the process of communication of the notary with visitors and clients. Since the worldview function is one of the central for philosophy, the principal value in all types of worldview, which include mythological, religious and philosophical, is man as a subject of knowledge. But only philosophy, advocating for self-knowledge, recognizes it as the highest value. In the mythological worldview, a man, when placing his mental inclinations in the natural environment, does not yet rise to the realization of his value and self-worth. Religious worldview, denying the anthropomorphic view of the world, is based on reason and will as world-creative principles. In fact, these are attributive value properties of man, which, because the interaction between people does not give grounds to claim that it is based on rational-volitional motivation, are alienated from real people in favor of the Absolute, which is God as the highest value, who through people like him in reasonable will and love, gives them instructions for life, which they, in fulfilling his will, convey to the average "sinful" people. The philosophical worldview is based on the fact that each person is able to assert their own self-worth if they engage in self-awareness through the opportunity to have freedom of thought, her and his spiritual-cognitive space created by prominent thinkers throughout the history of knowledge. Knowing the peculiarities of a man’s worldview motivation, the notary largely takes this into account when performing his professional duties.
TEACHERS’ DISCOURSE: NEUROETHICAL PRINCIPLES
Authors: Truba Hanna
Published: January 2022

The aim of this paper is to describe two different categories: the teacher discourse and neuroethical principles. New reality of life and general digitalization brings new opportunity not only to students to study any course but also it brings ability to the teachers to worldwide their lessons. Therefore, it faces new challenges and imposes great responsibility for teachers. We all should to find out the new ethical principles. The teachers’ discourse refers to a type of communication that presupposes professional communication between persons belonging to the same group in a professional institution, in the center of which is the discursive activity of representatives of the scientific community, which ensures the embodiment of their intentions and the achievement of a perlocutionary effect. With the aim of transferring professional knowledge and for the intellectual and emotional impact on the addressee, where his essential characteristics reflect the general human, ethnic and interpersonal properties inherent in society and the scientific continuum, implemented within the framework of a social institution. Methods used in the study: general scientific (analysis and synthesis, induction and deduction), methods of theoretical research (from abstract to concrete), the method of description.
Tante Ebba og Revolutionen: Historien om de sønderjyske krigsfangers «danske moder» i Rusland
Authors: Nielsen Jens Petter
Published: January 2022

Denne boka handler om en dansk kvinne som skjebnen bringer til Russland i 1911 og som senere skriver en interessant øyenvitenberetning om Den russiske revolusjon, der danske, sønderjyske soldater i russisk krigsfangenskap spiller en sentral rolle.  
The subject of this book is a Danish woman whom fate brought to Russia in 1911. She later  wrote an eyewitness account of the Russian Revolution where captured Danish soldiers from South Jutland play an important part.
Family and the State in Soviet Lithuania: Gender, Law and Society
Authors: Johannsen Lars
Published: January 2022

Dahlia Lenairte's Family and the State in Soviet Lithuania: Gender, Law and Society (2021) offers an account of the changing role and position of women in the family and in society under the Communist reign in Lithuania. Beginning with the first Soviet occupation before the Second World War, Lenairte details the massive changes from Catholicism to Communism with respect to gender policy, family, divorce, childcare, maternity leave, and finally housing, up until the 1980s. Importantly, she shows that, contrary to common belief about Communist policy, gender equality was in fact never achieved in Soviet Lithuania.
Dahlia Lenairtes bog Familie og stat i Sovjet Litauen: Køn, lov og samfund (2021) er en gennemgang af kvinders ændrede roller og position i samfundet og familien under det kommunistisk styre i Litauen. Med et afsæt fra den første sovjetiske besættelse før 2. Verdenskrig viser Lenairte de enorme ændringer der skete fra katolicisme til kommunisme med hensyn til ligestilling, familie, skilsmisse, børnepasning og barselsorlov, og endelig boligsituationen op til begyndelsen af 1980'erne. I modsætning til den almindelige forståelse af kommunistisk ligestillingspolitik bliver det tydeligt, at kvinder aldrig opnåede at blive ligestillet med mænd.
Upaya Meningkatkan Kemampuan Motorik Halus Anak Melalui Kegiatan Meronce Dari Bahan Alam Biji Hanjeli
Authors: Roostin Erna
Published: January 2022

Penelitian ini dilatarbelakangi oleh rendahnya kemampuan motorik halus anak, sehingga dirasa perlu menciptakan suatu kegiatan pembelajaran yang efektif untuk meningkatkan kemampuan motrik halus tersebut. Salah satu upaya yang dilakukan adalah melalui kegiatan meronce dari bahan alam biji hanjeli. Tujuan dari penelitian ini adalah mendeskripsikan kemampuan motorik halus anak melalui kegiatan meronce dari bahan alam biji hanjeli pada anak kelompok A usia 4-5 tahun,  metode yang digunakan adalah Penelitian Tindakan Kelas (PTK) dengan menggunakan desain yang dikembangkan oleh Kemmis dan Mc Taggart terdiri dari empat komponen yaitu: perencanaan, tindakan, observasi, dan refleksi. Penelitian ini dilakukan secara daring (online) dan instrument yang dilakukan yaitu berupa lembar unjuk kerja kemampuan motorik halus anak. Berdasarkan hasil penelitian tindakan kelas ini adalah melalui kegiatan meronce dari bahan alam biji hanjeli kemampuan motorik halus anak kelompok A Kober Aulia Desa Gendereh Kecamatan Buahdua Kabupaten Sumedang tahun pelajaran 2019/2020 dapat ditingkatkan. Hasil akhir pada siklus II menunjukan persentase yang mencapai target kemampuan motorik halus adalah 92%, dengan rata-rata skor kemampuan motorik halus anak secara klasikal mencapai 3,5 dengan kategori berkembang sangat baik (BSB).

Kata kunci: kemampuan motorik halus, kegiatan meronce
Formation features of professional stress and emotional burnout in firefighters-rescuers
Authors:   Tver State Technical University, Filippchenkova S.I.
Published: January 2022

The article presents the results of a study of the peculiarities of the formation of professional stress in Emergencies Ministry officials. The psychological structure of the symptoms of emotional burnout syndrome and its relationship with the level of neuropsychic stability of firefighters and rescuers of the Tver region were revealed. The diagnostic tools of the study were made up by the methods of V.V. Boyko and Yu.A. Baranova. Based on the results of the study demonstrating the relationship of acute stress disorders with the specifics of professional activity, the conclusion about the presence of burnout syndrome in formative stage in firefighters and rescuers and about a sufficiently high level of neuropsychic stability, allowing Emergencies Ministry officials to work successfully.
Competitiveness as an invariant of professionalism of management entities
Authors:   Russian Technological University, Institute of Management Technologies, Posokhova A.V.
Published: January 2022

The position on competitiveness as a psychological invariant of professionalism of management subjects is substantiated. The psychological content of the invariance principle and its application in psychology are revealed. The definition of psychological invariants of professionalism is presented, their types are described. The personal correlates of competitiveness, entrepreneurship, economic thinking, business activity and business acumen are described.
The phenomenon of secrecy in the context of the COVID-19 pandemic and the bioethical issue
Authors:   Tver State Technical University, Evstifeeva E.A. , Komarov G.V. ,   Tver State Technical University
Published: January 2022

The article is devoted to the philosophical conceptualization of the phenomenon of secrecy in the context of the COVID-19 pandemic and the bioethical problem of collective well-being. It is shown that the «will to not know» about the coronavirus is a kind of mystery about its origin and consequences, and a variant of human constitution. The rationale is given that the pandemic entails a revision of the principles of bioethics about justice, collective welfare and personal autonomy, individual human health.