bluuebunny/crossref_metadata_2025 huggingface dataset:
Temporality of trauma (reflecting on the book by Zh. T. Toshchenko)
Authors: Yarskaya-Smirnova Valentina
Published: March 2023

This article introduces the reader to reflections on the fundamental scientific publication of Zh.T.Toshchenko. The intersection of the discourses of historical time and social trauma is explained as a still poorly studied phenomenon of reality. All sections of the book are analysed in detail, in the form of a round table with scientists interested in the subject of the monograph under discussion. The article shows Toshchenko's interest in detailing the conceptual apparatus of the book, his desire to reveal concepts, paradigms, theories and definitions, integrating scrupulousness in the analysis of cases and examples with a generalisation of world and national history. The article contains an analysis of the disclosure in the monograph of the categories of progress, evolution and revolution, the definition of generic and specific features of the society of trauma in the absence of a development strategy and state ideology. In unison with the new bestseller, the article gives an example of a revolution in the discourse of the refraction of time in Russian history as a motley non-linear temporality of 1917 and the entire 20th century. A dramatic traumatic intersection of historical time by the event of a revolution that shook the world and overturned the established system of social coordinates was revealed. The article emphasises the conclusion about the Russian trauma as a result of historical upheavals that exposed the crisis of civilisation, the relationship between Russia and the West, the people and the intelligentsia, power and society. The temporal turn turns out to be a useful tool for understanding the concept of trauma of society, that has come into trend of modern scientific directions. The article provides with additional examples of traumatic events and cases of optimisation in Russian education and healthcare. Monographic conclusions relate to overcoming the trauma of society by means of achieving the strategic goal of development - social justice, solving social problems, eliminating inequality and mobilising creative potential. The article reveals the merits of the monograph, including interdisciplinarity and universality, original analytical perspectives and conceptual possibilities. The article also contains recommendations for universities to create a special course for undergraduate and graduate students on the basis of the book´s content.
Tourism-based Cultural Education
Authors: Kurniawan Ahmad
Published: March 2023

In the development of the world of education, especially in the specialization of social sciences in high schools, they do not understand the philosophy of the subjects delivered by educators. Even though based on the research findings, it shows that the world of education in Indonesia has now been juxtaposed with cultural education, but teachers still feel worried about how the achievements of the subjects given can be applied to their students. This is evidenced by direct observations to the class, asking how important the subjects they live are. They said that the knowledge they learned seemed to only be a complement to the graduation requirements for advancing to grades. With this phenomenon, it means that the curriculum model that has been arranged in such a way is only a mere contestation, so it is necessary to add a tourism-based cultured education curriculum model. This arises because seeing the enthusiasm of students when they study social science which is always associated with tourism science becomes more enthusiastic in following the whole learning process. By using the SLR (study literature review) research method, the researcher only focuses on literature review that can strengthen the researcher's argument in reviewing this research which aims to see the effect of the effectiveness of the new model style in cultural education associated with tourism science.
Pengaruh Keberadaan Dapur Setiap Outlet dalam Menunjang Kelancaran Pelayanan di Food & Beverage Department, The Rich Jogja Hotel
Authors: Supriyanto Slamet , Prasasti Ajeng Sonya Citra , Yulianto Gunawan
Published: March 2023

ABSTRACT

The Rich Jogja Hotel seeks to maximize service in this case services related to products produced by the kitchen according to the outlets owned to satisfy guests. With these problems, research is carried out using qualitative research methods, where this research is carried out by collecting data based on research including observation, documentation, data analysis and literature review from various sources.

The success of kitchen services at each outlet will be supported by the presence of a kitchen in each outlet itself, its location, and staff who participate in carrying out tasks based on responsibilities.

Keywords: Kitchen, service, human resources
26 Prelúdios característicos e concertantes para Violino só, Doce momento e Serenim
Authors: Valle Flausino , Feichas Leonardo Vieira ,   Universidade Federal do Acre
Published: March 2023

Flausino Valle (1894-1954), natural de Barbacena - MG, mudou-se aos 18 anos para Belo Horizonte, onde foi violinista, advogado, escritor, professor de História da Música e Folclore, poeta e compositor. Sua obra musical para violino é marcada pela imitação/evocação de paisagens sonoras mineiras do começo do século XX como porteiras, carros de boi, animais e uma forte referência à viola caipira, alcançada por meio de hibridização de várias técnicas instrumentais e do uso de técnicas estendidas. Este livro de edições práticas das obras 26 Prelúdios Característicos e Concertantes para Violino Só, Doce Momento e Serenim, compostas por Valle, é um dos resultados do doutorado em Artes Musicais, realizado pelo organizador Leonardo Feichas na Universidade Nova de Lisboa, em cotutela com a Unicamp. Nessas edições práticas, são propostas visões interpretativas de arcadas e dedilhados, que, quando associadas à leitura da tese de Feichas, fornece uma visão do entendimento sobre essas obras. A proposição destas edições vai ao encontro de um dos desejos de Valle, de que sua obra fosse usada como método de estudo de violino nos cursos de música, nos conservatórios e nas universidades.
Design Form by Right Diagonal Line Asymmetrical Cut according to Head Region Division, Angle and Slice Line
Authors: Guk Hye Ran
Published: March 2023

Purpose: This research focuses on a creative design cut with right diagonal line asymmetrical haircuts according to head region division, angle, and slice line. Of late, managing customers in the hair beauty industry has been difficult because customers are always looking for new things; therefore, a haircut with a new and creative design is required. This study provides basic data on haircuts.Methods: Hair on the top of the head was divided into three sections: golden-back medium point, back-point, and back-nape medium point. Hair on the upper part of the head was cut at 0°, 30°, and 60°, and the lower part of the head was cut at 45°; however, only the hair on the upper part of the head was used for length measurement.Results: The natural procedure angle of 0° represents smooth and straight textures. In addition, the volume, weight, and expansion increase with the area. Smooth and coarse textures exhibited fine layers at 30° and natural layers at 60° simultaneously. The parallel line becomes straight; further, the A (diagonal) and the V (diagonal) lines elongate and shrink toward the face line, respectively.Conclusion: The right angle line asymmetry cut can provide freshness, liveliness, and rhythm feeling through unbalance. In addition, the length of the right side increases, resulting in a heterogeneous effect. In the future, the volume cut and length changes will be studied based on the jawline, neckline, and clavicle.
Satisfacción laboral de los académicos de la licenciatura de cirujano dentista de la Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México
Authors: Gómez-Carlos Alejandra , Taboada-Aranza Olga , Sánchez-García Juan Pablo
Published: March 2023

Objetivo: Conocer la satisfacción laboral en los académicos de la licenciatura de Cirujano Dentista del Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México en el período 2019. Material y métodos: Estudio observacional, prolectivo, transversal, descriptivo. La población de estudio estuvo conformada por 123 académicos, a los que se les aplicó un cuestionario de 20 ítems con respuestas en escala Likert (α de Cronbach 0.845). Resultados: Del total de encuestados, el 45% (55) del sexo masculino, 55% (68) del femenino, con una media de edad de 36.5 (± 9.6) años. El 48% (59) de los académicos se encuentran satisfechos con el trabajo docente que realizan, en contraste, el 25% (31) está muy insatisfechos. Entre los factores que influyen en la insatisfacción se encontró: La carga horaria, sobre todo los que tienen en turno mixto, el poco apoyo que la institución da para estudiar un posgrado, el estrés que conlleva la responsabilidad de supervisar a los estudiantes en el área clínica en la atención a pacientes. La insatisfacción se presenta en mayor proporción en académicos con una edad ≥ 50 años. Conclusiones: Los factores referidos que influyen en la insatisfacción son: el bajo salario, las inadecuadas instalaciones para impartir clase, la falta de apoyo para la capacitación por parte de la institución, el no reconocimiento al trabajo realizado. Llama la atención que, en la licenciatura de Cirujano Dentista donde el trabajo en equipo es de suma importancia, este no se dé o se dé muy pocas veces.
Effect of different conditions and modes of application on bond strength of adhesives to dentine
Authors: Cestari Fagundes Ticiane , Simões Gonçalves Rafael , De Souza e Silva Ramos Fernanda , De Castro Oliveira Laryssa , Dias Moda Mariana , Sanae Shinohara Mirela
Published: March 2023

Objetivo: Evaluar la resistencia de la unión microtensil en diferentes condiciones de dentina (grabado-E, sin grabado-N, seco-D y húmedo-W) de un adhesivo multimodo (Scotchbond Universal-SU, 3M/ESPE) y un adhesivo de grabado total (Ambar-AB, FGM) utilizando un dispositivo sónico (Smart Sonic Device-SD, FGM). Material y Métodos: En este estudio in vitro, noventa y seis molares humanos extraídos sanos se dividieron en 12 grupos (n=8) de acuerdo con diferentes condiciones de dentina y sistemas adhesivos. Se eliminó el esmalte y se pulieron las superficies centrales de la dentina. Cada sistema adhesivo se aplicó de acuerdo con las diferentes condiciones de dentina, y los bloques de resina compuesta se acumularon de forma incremental y se almacenaron durante 24h. Las muestras se seccionaron en barras y los datos de resistencia de la unión se analizaron con la prueba de Kruskal-Wallis y la prueba de U de Mann-Whitney. Resultado: No se observaron efectos de la aplicación sónica. En general, AB mostró resultados más bajos en comparación con el SU. Las condiciones E y N no afectaron estadísticamente la fuerza de unión de los grupos SU. La dentina seca presentó valores de fuerza de adhesión estadísticamente superiores en comparación con la dentina húmeda para el grupo SU/E/SD. Conclusión: La adhesión de la dentina seca con un sistema adhesivo multimodo puede ser superior a la dentina húmeda con aplicación sónica. Los modos de aplicación no tuvieron influencia en la resistencia de la unión de los adhesivos estudiados.
Variantes anatómicas del foramen mentoniano
Authors: Vinatea Cuenca de Figueroa María Teresa , Miroslava Quezada-Márquez Milushka
Published: March 2023

El foramen mentoniano es un hito anatómico en la cara externa del cuerpo mandibular del que emergen el nervio mentoniano y su paquete vascular. Podemos observar más forámenes, tanto en la cara externa como en la cara lingual de la mandíbula. Se denominará foramen mentoniano accesorio si se comprueba su continuidad con el conducto mentoniano o con el conducto dentario inferior, y se llamará foramen lingual lateral si se continúa con el conducto dentario inferior y emerge en la superficie lingual, distal a la zona de caninos. Se pueden presentar otras variantes anatómicas menos frecuentes como la agenesia uni o bilateral del foramen mentoniano y la presencia del foramen incisivo. La detección de las variantes anatómicas del foramen mentoniano es de gran importancia en el planeamiento de diversos tratamientos invasivos en la zona, para evitar disturbios sensoriales y accidentes vasculares
Numerical analysis of the adhesion strength between layers of composite polymeric materials
Authors: Makovskyi Vladyslav , Chemerys Andrii
Published: March 2023

In today's world, structural elements made of composite polymeric materials (CPMs) are widely used in various engineering fields. One of the innovative directions of using CPMs is the creation of composite membranes based on a different set of polymers and fabrics. Based on the results of the literature analysis, the direction of studying the adhesion strength of banner fabric layers was chosen.

The purpose of this work is to build a computational model and numerically analyze the adhesion strength of the layers of the banner fabric, which may lead to the development of new materials with improved mechanical and physical properties. This will ensure their wider application in various industries, science, and technology.

The developed methods make it possible to accurately assess the adhesion strength between the layers of the CPM and can be used both in the production of CPM and in the creation of new structures based on composite polymeric materials.
Estimation of House Cleanup Work Volume Based on Disaster Volunteer Center Work Management Data —The Case of the 2015 Joso City—
Authors: Mizui Yoshinobu , Fujiwara Hiroyuki
Published: March 2023

To understand the workload of house cleanup and related workforce shortage after a disaster, the actual work situation in disaster-stricken areas is accounted for by disaster volunteer work management data created by the Disaster Volunteer Center of Joso City in Ibaraki Prefecture at the time of the Kanto–Tohoku Heavy Rain Disaster in September 2015. Using the classification of inundation depth, judged from ground elevation, the weekly workload of house cleanup according to the work content is recorded to clarify the characteristics of each area. Comparing this with the inundated areas without destructions by water flow, near the bank break with house destructions, in the urban area, and around the farmland along the old road, a model to estimate the workload is constructed. It was observed that indoor work to recommence living in urban areas continued for a long time, while the work was completed in a relatively short time in the area along the old road. The area near the bank break, with a small number of houses, witnessed very few house destructions. Hence, it is not necessary to separately calculate the workload caused by house destructions. The appropriateness of the estimated results was verified by using a method to estimate the workload based on the amount of disaster waste. As a result, the total workload estimated by disaster volunteers and victims for the busy period of two months was a million people. In the case of the Joso City flood, very few houses were completely destroyed, therefore, regular living could be resumed swiftly and people settled there after the disaster due to its proximity to the metropolitan area. Hence, the population decreased by the flood was recovered in two years.
Meningkatkan Kualitas Pendidikan Karakter di Jenjang Sekolah Dasar
Authors: Ifnuari Moh. Reza
Published: March 2023

Pendidikan karakter merupakan upaya penguatan dan peningkatan nilai moral atau etika bangsa, khususnya peserta didik yang akan menjadi generasi penerus bangsa dan ujung tombak keberhasilan suatu bangsa yang berkarakter mulia, terutama pada golden age yaitu pada Pendidikan anak sekolah dasar. Negara bertanggung jawab untuk itu dengan melestarikan nilai-nilai luhur yang telah dimiliki oleh nenek moyang kita sebelumnya, dimana nilai-nilai tersebut merupakan cara untuk mempersatukan keragaman bangsa Indonesia, dari suku, ras dan agama. Upaya peningkatan pendidikan karakter di sekolah merupakan salah satu cara untuk mengantisipasi dan meminimalisir kemerosotan moral bangsa yang menjadi permasalahan dalam dunia pendidikan khususnya di Indonesia. Penelitian ini bertujuan untuk mengidentifikasi manajemen pendidikan karakter di sekolah. Penelitian ini merupakan penelitian tinjauan pustaka. Tinjauan Pustaka Literatur digunakan untuk mendapatkan artikel dari database online yang relevan dengan manajemen pendidikan karakter di sekolah dari tahun 2015 hingga 2020. Hasil dari 22 pasal yang diulas adalah peningkatan pendidikan karakter membutuhkan kerjasama antara guru, seluruh warga sekolah, orang tua, masyarakat, sehingga apa yang telah ditentukan dapat terwujud yaitu siswa yang memiliki dan menanamkan nilai-nilai moral dalam kehidupan.
PENINGKATAN MINAT MEMBACA WARGA BELAJAR MELALUI KAMPUNG LITERASI DI PKBM AL-HIDAYAH TASIKMALAYA
Authors: Herwina Wiwin , Dede Nurul
Published: March 2023

Membaca sangat penting bagi kehidupan manusia. Namun demikian, minat membaca warga belajar di Indonesia sampai dengan sekarang ini sangatlah rendah. Rendahnya minat baca di Indonesia dilihat dari beberapa bukti-bukti maupun riset yang sudah dilakukan. Tujuan penelitian ini adalah untuk mengkaji bagaimana peningkatan minat membaca warga belajar dengan adanya Taman Bacaan Masyarakat (PKBM) di PKBM Al-Hidayah Tasikmalaya. Penelitian ini merupakan jenis penelitian kualitatif, dengan metode penelitian yaitu metode studi kasus. Penelitian dilakukan pada PKBM Al-Hidayah Kabupaten Tasikmalaya Provinsi Jawa Barat. Waktu pelaksanaan penelitian berlangsung selama 6 (enam) bulan, yaitu dari bulan April 2020 sampai dengan September 2020. Hasil penelitian menunjukkan minat membaca warga belajar dapat meningkat dengan adanya kampung literasi di PKBM Al-Hidayah Tasikmalaya. PKBM Al-Hidayah Tasikmalaya dijadikan sebagai sumber belajar masyarakat, sumber informasi masyarakat, kepala dan pengelola sebagai motivator, pembimbing, dan stimultan minat baca bagi masyarakat, serta sumber hiburan masyarakat menjadi bukti bahwa telah terjadi peningkatan minat baca di masyarakat.

Kata-kata kunci:  Literasi, peningkatan, membaca, minat.
Digital Twin concept of a force measuring device based on the finite element method
Authors: Baer Oksana , Giusca Claudiu , Kumme Rolf , Prato Andrea , Sander Jonas , Mirian Davood , Hauschild Frank
Published: March 2023

In the framework of EMPIR project ComTraForce, the Digital Twin (DT) concept of force measurement device is developed. DT aims to shade static, continuous as well as dynamic calibration processes, preserving data quality and collecting calibration data for improved Decision-making. To illustrate the developed DT concept, a prototype realisation for static and continuous force calibration processes is developed, involving simulation with ANSYS engineering software. The focus of the current work is placed on the data connection between the physical device and the DT. The DT model is validated using traceable measurements.
Diagnosis of rotating machine defects by vibration analysis
Authors: Bouaouiche Karim , Menasria Yamina , Khalfa Dalila
Published: March 2023

This work presents the analysis of the vibration signals of a ball bearing, the signals available on the platform Case Western Reserve University in the form of MATLAB files. By proposing an approach for the diagnosis of any rotating machine and detects the failed components in a simple way, the proposed approach consists of several methods and steps each complementary to the other. First on decomposing the signal by the feature mode decomposition (FMD) method and then, according to the Kurtosis values by selecting the useful signals after the selection by computing the sum of the useful signals called the residual of the original signal. The simplicity of the form of the residual makes through the application of band pass filtering and Hilbert transform, but the analysis of the peaks represents the frequency of the failed components.
Analisis Kemampuan Membuat Solusi Melalui Kegiatan Eksperimen
Authors: Rohmawati Athik Abida , Fadly Wirawan
Published: March 2023

Kemampuan membuat solusi memiliki peranan penting dalam proses pembelajaran IPA dan menjadi salah satu kemampuan yang harus dikuasai oleh siswa. Kemampuan membuat solusi dalam kegiatan eksperimen siswa belum maksimal dikarenakan siswa sering mengalami kesulitan dalam memecahkan masalah saat kegiatan eksperimen serta tidak mengutamakan teknik penyelesaian tetapi lebih memprioritaskan hasil akhir. Tujuan dari penelitian ini yaitu mendeskripsikan: 1) kemampuan membuat solusi siswa dalam melaksanakan kegiatan eksperimen IPA. 2) upaya guru IPA dalam mengembangkan kemampuan membuat solusi siswa pada kegiatan eksperimen IPA, serta 3) faktor yang mempengaruhi kemampuan membuat solusi siswa dalam melaksanakan kegiatan eksperimen di MTs Negeri 4 Ponorogo. Penelitian menggunakan jenis penelitian kualitatif dengan desain fenomenologi pengumpulan data menggunakan Software NVivo12, observasi, dan wawancara. Dalam menganalisis data penulis menggunakan analisis dari Miles & Huberman dengan langkah kondensasi data, penyajian data, dan penarikan Kesimpulan. Hasil penelitian menunjukkan 1) kecenderungan siswa dalam melaksanakan solusi praktikum diawali dengan menyusun strategi secara ilmiah dan campuran dalam menyelesaikan masalah eksperimen. 2) terdapat 2 upaya yaitu memberikan perintah kepada siswa untuk melakukan kegiatan eksperimen sendiri dan membuat LKPD sebagai fasilitator belajar. 3) faktor yang mempengaruhi yaitu faktor input siswa yang berupa kondisi psikologis dan fisiologis. Dukungan keluarga menjadi faktor yang berpengaruh terhadap siswa dalam melakukan eksperimen.
Analisis Miskonsepsi Ditinjau dari Gaya Belajar dengan Certainty of Response Index
Authors: Ayuni Azhar , Arif Syaiful
Published: March 2023

Pada materi getaran, gelombang dan bunyi memiliki berbagai  macam  konsep yang dapat menimbulkan miskonsepsi pada peserta didik. Miskonsepsi dapat terjadi akibat tidak sama antara konsep peserta didik dengan konsep para ahli. Salah satu penyebab miskonsepsi ialah gaya belajar peserta didik. Miskonsepsi membuat peserta didik salah memahami konsep sehingga hasil yang diperoleh kurang maksimal. Peserta didik kelas VIII A MTsN 2 Ponorogo mendapatkan hasil diatas standar minimum yang ditetapkan kecuali materi getaran, gelombang dan bunyi. Sehingga perlu dilakukan analisis dengan pendekatan kualitatif metode deskriptif. Sehingga dapat didapatkan hasilnya ialah peserta didik gaya belajar  visual memiliki miskonsepsi tertinggi pada miskonsepsi berdasarkan fakta, gaya belajar auditorial miskonsepsi yang tertinggi pada miskonsepsi konseptual yang salah dan gaya belajar kinestetik mempunyai miskonsepsi tertinggi pada miskonsepsi berdasarkan fakta.
Combinatorial Analysis of the Exponential Map for Time-Evolution Operator
Authors: CEYLAN Ali Mert , AYTAÇ Vecdi
Published: March 2023

In this study, we present a novel formalization for exponential approximation.
This formalization is for discrete analysis of continuous
time-dependent perturbation operator of quantum mechanics, compared
to multiplying exponentials. This leads us to Galton arrays for
better representation and algebraic operations over exponential multiplications.
Rotations on Galton arrays allow us to perform various
algebraic operations and intuitively explain commutative and noncommutative
operators equality in exponential approximations. Proposed
algebraic operations over Galton arrays will provide an easier
understanding and a novel way to formalize and visualize multiplying
exponentials. But most importantly, it focused on the timeevolution
operator to be written in the proposed formalization of timeordered
multiplication of exponentials with noncommuting operators.
Quasiperiodic circuit quantum electrodynamics
Authors: Koenig Elio , Herrig Tobias , Pixley Jedediah , Riwar Roman-Pascal
Published: March 2023

Superconducting circuits are an extremely versatile platform to realize quantum information hardware, and, as was recently realized, to emulate topological materials, such as three-dimensional Weyl semimetals or two-dimensional Chern insulators. We here show how a simple arrangement of capacitors and conventional superconductor-insulator-superconductor (SIS) junctions can realize a nonlinear capacitive element with a surprising property: it can be quasiperiodic with respect to the quantized Cooper-pair charge. Integrating this element into a larger circuit opens the door towards the engineering of an even broader class of systems. First, we use it to simulate a protected Dirac material defined in the transport degrees of freedom. The presence of the Dirac points leads to a suppression of the classical part of the finite-frequency current noise. Second, we exploit the quasiperiodicity to implement the Aubry-André model, and thereby emulate Anderson localization in charge space. Importantly, the realization by means of transport degrees of freedom allows for a straightforward generalization to arbitrary dimensions. Moreover, our setup implements a truly non-interacting version of the model, in which the macroscopic quantum mechanics of the circuit already incorporates microscopic interaction effects. We propose that measurements of the quantum fluctuations of the charge can be used to directly probe the localization effect. Finally, we present an outlook in which the nonlinear capacitance is employed in a quantum circuit emulating a magic-angle effect akin to twisted bilayer graphene.
Factors Causing Delayed Presentations of Breast Cancer among Female patients in Sulaimaniyah Governorate, Iraq
Authors: Abdulkareem Alaa Abdulrazzaq , Ghalib Hawar Ali , Rashaan Mezjda Ismail
Published: March 2023

Background: Since breast cancer (BC) has the best chance of being effectively treated when it is tiny and has not spread, encouraging early disease detection remains a fundamental goal in improving prognosis.
Objective: To better understand what factors contribute to a late presentation of BC, how this affects disease progression, and to assess awareness of BC warning signs.
Patients and methods: Data was collected at the Breast Diseases Treatment Clinic, Shar Teaching Hospital, Sulaimaniyah, Iraq Sulaimani, from January 2017 to December 2021 on 429 patients. A questionnaire was distributed to women about their demographics, health, and general awareness of the disease. The patient delay was calculated by collecting information on when they initially began experiencing symptoms and when they saw a doctor. We also gleaned information about the tumour's clinicopathological features from the patient's medical records.
Results: The participants' age ranged from 24 to 85 years, with a mean of 49.6±11. Most women were middle-aged (53.8%), from urban areas (80.2%), illiterate (41.7%), married (86.5%), housewives (79.0%), given birth to>4 children (34%), practised breastfeeding (78.8%), and no smokers (91.4%). Regarding patients' health behaviours associated with delay in breast cancer presentation, there were highly significant correlations between early and late screenings (P<0.001). Concerning the patient’s awareness of breast cancer symptoms, there were highly significant correlations between early and late screenings (P<0.001). In addition, the late presentation was strongly correlated with bilateral BC, lymph node involvement, inflammatory breast carcinoma, grade III of BC, and T4 status.
Conclusions: Our findings shed light on possible causes of late presentation and identified those at risk of delayed consultation. Our communities need to be educated about BC, and encouraging them for early detection, decreases the incidence of advanced BC.
Integration of AIEgens into Covalent Organic Frameworks for Pyroptosis and Ferroptosis Primed Cancer Immunotherapy
Authors: Zhang Liang , song An , Yang Qi-Chao , Li Shu-Jin , Wang Shuo , Wan Shu-Cheng , Sun Jianwei , Kwok Ryan T. K. , Lam Jacky , Deng Hexiang , Tang Ben Zhong , Sun Zhijun
Published: March 2023

We report the construction of covalent organic framework (COF-919) from planar and twisted AIEgens-based motifs as a pyroptosis and ferroptosis dual-inducer that can elicit strong inflammatory response for efficient antitumor immunity. Mechanistic studies revealed that, in contrast to traditional COFs constructed with solely planar or twisted motifs, COF-919 displays stronger near-infrared light absorption, lower band energy and longer lifetime to favor the reactive oxygen species (ROS) generation and photothermal conversion for trigger pyroptosis. Because of its outstanding ROS production capability, intracellular lipid peroxidation was also upregulated to lead to glutathione depletion, glutathione peroxidase 4 low expression, and the induction of ferroptosis. Moreover, COF-919 induced pyroptosis and ferroptosis can effectively reshape the tumor immune microenvironment (TME) via promote T cells infiltration and relieve immunosuppressed TME to boost a T-cell-mediated immune response, which is favorable for inhibiting tumor metastasis and recurrence, with > 99% tumor growth inhibition and > 80% cure rates.
Microvascular bleeding control by POC Guided transfusion in high risk cardiac surgery: What about the empiric approach in bleeding with normal labs in POC
Authors: Kling-Gómez Juan Carlos , Soriano Laura Gutiérrez – , Herrera Laura Ramírez – , Orduz Andrea Jiménez – , Maya-Trujillo Nicolás , Becerra-Zapata Eduardo
Published: March 2023

Objective: To evaluate the effects of POC guided and empiric transfusions in patients with microvascular bleeding (MVB) in high risk cardiac surgeries.
Design: This was a prospective, observational study
Setting: The study was performed at a single cardiovascular university hospital.
Participants: Thirty-three patients under point of care (POC) guided transfusion were compared with twenty-seven patients undergoing empirical transfusion.
Interventions: No interventions were performed
Measurements and Main Results: Coagulation products used and its dosing, as well as need of transfusion in ICU, re-exploration and use of factor VII were compared between two groups (POC and Empiric approaches). There were 36 patients managed by POC and 27 empirically. Between POC patients 25% (n=9) had normal lab values and even though they needed transfusions. No differences were found in platelets usage, being the first product used 87% ( 83% POC v. 93% Empiric) nor cryoprecipitates 65% (72% POC v. 56% Empiric). Fresh frozen plasma was used almost twice in the empirical group 74%( 89% POC v. 56% Empiric p:0.0045). In a few cases just one coagulation product was used 25% (19% POC v. 33% Empiric), while in the majority of cases more than one was necessary 75% (81% POC v. 67% Empiric). No differences in doses used were found (mean: platelets 6-10 ml/kg, FFP >10 ml/kg, cryoprecipitates <5 ml/kg). Patients in POC group had significantly more re-exploration (53% POC v. 26% Empiric p:0.0182), abnormal labs at ICU admission (47% POC v. 26% Empiric), and needed more transfusions at ICU (64% POC v. 33% Empiric p:0.0096). Factor VII was required in 8 (12,7%) patients and all of them belong to POC group and all of them needed to be re-explored. 13% of patients required Factor VII use and all were from POC group (p:0.0039)
Conclusions: This study shows there is no difference between quantity of products used in both groups, but POC focuses more on each deficiency with an specific coagulation product unlike empirical approach. For that reason POC is more restrictive, requiring more re-explorations, more use of factor VII, more transfusions and finding more lab abnormalities in the ICU.
Experimental characterization of the thermo-optic coefficient vs. temperature for 4H-SiC and GaN semiconductors at the wavelength of 632 nm
Authors: Rao Sandro , Mallemace Elisa D. , Faggio Giuliana , Iodice Mario , Messina Giacomo , Corte Francesco G. Della
Published: March 2023

The design of semiconductor-based photonic devices requires precise knowledge of the refractive index of the optical materials, a not constant parameter over the operating temperature range. However, the variation of the refractive index with the temperature, the thermo-optic coefficient, is itself temperature-dependent. A precise characterization of the thermo-optic coefficient in a wide temperature range is therefore essential for the design of nonlinear optical devices, active and passive integrated photonic devices and, more in general, for the semiconductor technology explored at different wavelengths, from the visible domain to the infrared or ultraviolet spectrum. In this paper, after an accurate ellipsometric and micro-Raman spectroscopy characterization, the temperature dependence of the thermo-optic coefficient (\(\partial n/\partial T\)) for 4H-SiC and GaN in a wide range of temperature between room temperature to T = 500K in the visible range spectrum, at a wavelength of λ = 632.8 nm, is experimentally evaluated. For this purpose, using the samples as a Fabry-Perot cavity, an interferometric technique is employed. The experimental results, for both semiconductors, show a linear dependence with a high determination coefficient, R2 of 0.9934 and 0.9802, for 4H-SiC and GaN, respectively, in the considered temperature range.
Increased neurovirulence of omicron BA.5 over BA.1 in human brain organoids and K18-hACE2 mice
Authors: Stewart Romal , Ellis Sevannah , Yan Kexin , Dumenil Troy , Bishop Cameron , Tang Bing , Nguyen Wilson , Larcher Thibaut , Sullivan Robert , Lor Mary , Meunier Frederic , Rawle Daniel , Suhrbier Andreas
Published: March 2023

The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 remains controversial. We show that a BA.5 isolate was significantly more pathogenic in K18-hACE2 mice than a BA.1 isolate, with BA.5 infections showing increased neuroinvasiveness, resulting in brain infection and mortality, similar to that seen for original ancestral isolates. BA.5 also infected human cortical brain organoids to a greater extent than the BA.1 and original ancestral isolates. In the brains of mice neurons were the main target of infection, and in human organoids neuronal progenitor cells and immature neurons were infected. Evidence for brain infection and brain damage in certain COVID-19 patients is becoming compelling, with the results herein illustrating the increasing intrinsic neuropathogenic potential of evolving omicron variants.
Preoperative predictors for recurrence sites associated with poor post-recurrence survival after surgery of non-small cell lung cancer: a multicenter study
Authors: Isaka Tetsuya , Adachi Hiroyuki , Murakami Kotaro , Miura Jun , Kikunishi Noritake , Shigeta Naoko , Kudo Yujin , Miyata Yoshihiro , Okada Morihito , Ikeda Norihiko , Ito Hiroyuki
Published: March 2023

Background
The recurrence site that influences post-recurrence survival (PRS) in patients with non-small cell lung cancer (NSCLC) undergoing surgery and the preoperative predictors of recurrence remain unclear.
Methods
Cohorts 1 and 2 had 4520 (who underwent complete resection for p-stage 0-IIIA NSCLC) and 727 (who experienced recurrence after surgery) patients, respectively. The initial sites of recurrence were the lungs (309 cases), thoracic lymph nodes (225 cases), pleura (112 cases), bone (110 cases), central nervous system (86 cases), abdomen (84 cases), cervical and axillary lymph nodes (38 cases), chest wall (13 cases), skin (5 cases), and eye and tongue (3 cases). For cohort 2 analysis, the initial recurrence site that resulted in poor PRS was analyzed by multivariable analysis using a Cox proportional hazard model. For cohort 1 analysis, the preoperative predictors of recurrence patterns with poor PRS were analyzed by multivariable analysis using a logistic regression model.
Results
In cohort 2 analysis, recurrence in the central nervous system (hazard ratio [HR], 1.59; p=0.003), bone (HR, 1.67; p<0.001), abdomen (HR, 1.79; p<0.001), and pleura (HR, 1.72; p<0.001) were independent poor prognostic recurrent sites for PRS and they were high-risk sites (HRS). Thoracic lymph nodes, cervical and axillary lymph nodes, lungs, chest wall, eye and tongue, and skin were low-risk sites (LRS) that did not affect PRS. Patients with multiple LRS without HRS recurrence had a worse prognosis than those with a single LRS without HRS recurrence (5-year PRS 19.5% vs. 37.0%, p=0.001) and were comparable to those with HRS recurrence (p=0.806). In cohort 1 analysis, preoperative predictors for HRS and multiple LRS recurrences were positron emission tomography (PET) maxSUV ≥ 3.0 (HR, 6.09; p<0.001), clinical stage ≥ II (HR, 2.36; p<0.001), and carcinoembryonic antigen (CEA) ≥ 5 ng/ml (HR, 1.46; p=0.001). The cumulative incidence rates of HRS and multiple LRS recurrences within 5 years were 46.7%, 26.6%, and 3.2% (p<0.001) in patients with 3, 1-2, and 0 of the above risks, respectively.
Conclusions
HRS and multiple LRS recurrences were vital recurrences associated with poor PRS. Preoperative PET maxSUV, CEA level, and clinical stage can predict the incidence of vital recurrence.
Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis
Authors: Ning Zuodong , Huang Yunying , Lu Haocheng , Zhou Yong , Tu Tao , Ouyang Feifan , Liu Yaozhong , Liu Qiming
Published: March 2023

Purpose: Novel, effective, and safe preventive therapy targets for AF are still warranted. Circulating proteins with causal genetic evidence represents promising candidates. We aimed to systematically screen circulating proteins for AF drug targets and determine their safety and efficacy using genetic methods.
Methods: The protein quantitative trait loci (pQTL) of up to 1,949 circulating proteins were retrieved from nine large genome-proteome-wide association studies. Two-sample Mendelian Randomization (MR) and colocalization analyses were used to estimate the causal effects of proteins on the risk of AF. Further, phenome-wide MR was conducted to depict side effects and the drug-targets databases were searched for drug validation and repurposing.
Results: Systematic MR screen identified 30 proteins as promising drug targets. Genetically predicted 12 proteins increased AF risk (TES, CFL2, MTHFD1, RAB1A, DUSP13, SRL, ANXA4, NEO1, FKBP7, SPON1, LPA, MANBA); 18 proteins decreased AF risk (PMVK, UBE2F, SYT11, CHMP3, PFKM, FBP1, TNFSF12, CTSZ, QSOX2, ALAD, EFEMP1, FLRT2, LRIG1, OLA1, SH3BGRL3, IL6R, B3GNT8, FCGR2A). DUSP13 and TNFSF12 possess strong colocalization evidence. For these identified proteins, extended phe-MR conducted side-effect profiles, whereas drug targets databases presented the approved or investigated indications.
Conclusion: We identified 30 circulating proteins as potential preventive targets for AF.
Climate anxiety is associated with self-efficacy and behavioural engagement amongst adolescents: a cross sectional analysis
Authors: Turcotte-Tremblay Anne-Marie , Fortier Gabrielle , Bélanger Richard E , Bacque-Dion Claude , Gansaonré Rabi Joel , Leatherdale Scott T. , Haddad Slim
Published: March 2023

Background
Adolescents are increasingly aware of the treats of climate change and encouraged to take part in environmental actions. However, the current understanding climate anxiety adolescents is sparse. This study establishes the characteristics of adolescents who experience functional impairments induced by climate anxiety and who adopt pro-environment behaviours. It also characterizes the association between climate anxiety, feelings of self-efficacy and environmental actions.
Methods
2 379) from 113 schools in Quebec answered questions about climate anxiety, self-efficacy, behavioural engagement and several indicators of wellbeing. Data were analysed using poisson regressions adjusted for potential confounders (age, gender, school type, material deprivation, etc).
Results
More than one in ten adolescents (11%) reported that thinking about climate change makes it difficult to sleep or interferes with their ability to get work or assignments done. Only 35% of adolescents believed that they can do something to address the problem and 44% tried to reduce their behaviors that contribute to climate change. Adolescents who are boys and who are less anxious were less preoccupied and involved in the fight against climate change. Teenagers from less affluent families were more concerned, but not more engaged. Those with a good relationship with their family and strong school connectedness were both less concerned and more involved in the fight against climate change. Adolescents who felt they can do something about climate change were more likely to try to reduce behaviors that contribute to climate change.
Conclusion
The findings are useful to identify and support vulnerable groups that are more likely to experience functional impairments due to climate anxiety. The feeling of climate self-efficacy was not well developed among some groups of adolescents. Improving the youth’s beliefs in their capacity to help address the climate change may be a key strategy to promote pro-environmental actions. As the threat of climate change increases, it will be important to follow the evolution of climate anxiety and engagement amongst adolescents.
Simulation experiment of Internet online art design teaching based on computer image segmentation and Cluster algorithm
Authors: Zhang Yi , Liu Jun , Wu Xiaoli
Published: March 2023

With the continuous development of the economy, people pay more attention to spiritual needs, so the cultural industry has developed by leaps and bounds. The development of Chinese culture and art is transforming towards internationalization and industrialization, and new art forms and styles are constantly emerging. In addition, China's online education is currently in a critical period of transformation. The form of online education is comprehensively deepened, first of all in the field of basic vocational education; The second is the training of students in basic education. At present, the art design teaching courses in Chinese schools have not been fully digitized, and they are faced with the problems of outdated teaching materials, slow updating speed and high purchase cost. Based on this, this study designs an online art teaching system by introducing computer image segmentation technology. Through analysis, it can be concluded that the core algorithm of the system is superior to FCM, FCM_S1 and FCM_S2, etc., and is excellent in division entropy, coefficient and accuracy. and can fully drive the system designed in this paper. The main functional modules of the system include learning guidance, course guidance and teaching resources. Through the simulation experiment, the online art design teaching system of the Internet can fully meet the needs of many students to access through the intranet at the same time, and the external network can meet 500 concurrent users without pressure. So the overall system has good performance. This paper introduces the computer image segmentation technology into the field of art design teaching and designs a kind of effective Internet online system.
Development and validation of a scale for the assessment of the Knowledge-Attitude-Practice of Parents towards Children Snoring: A Cross-Sectional Study
Authors: GUO Siyan , HU Xiaoyue , WANG Xiaokai , TIE Hongyan , ZHANG Qiujun , Li Caixia , QIN Luying , Su Hongxia
Published: March 2023

Background: Children Snoring is a common childhood disorder that affects the growth and development of children and is detrimental to their health. However, awareness of the disease among parents in the community is at a low level.
Aim: To develop the Knowledge-Attitude-Practice of Parents towards Children Snoring Scale and test the reliability and validity of the scale.
Methods: The development of the tool has been divided into two phases involving 1257 parents from China. In the first phase, an initial project bank was created through a literature review. This was followed by a Delphi expert consultation, group discussion and pre-survey. The second stage screened the items and conducted an exploratory factor analysis, then conducted a confirmatory factor analysis and tested for reliability and validity.
Results: The scale has a good content validity index. It consists of four factors and 63.3% of the total variance is explained by 25 items. The confirmatory factor analysis also validates the 4-factor structure with a good overall reliability 0.93 and a test-retest reliability of 0.83. The scale is a good tool to measure the state of children’s parents about the Knowledge-Attitude-Practice toward Children Snoring.
Conclusion: The Knowledge-Attitude-Practice of Parents towards Children Snoring scale is a valid and reliable instrument.
Numerical simulating the influences of hydrate decomposition on wellhead stability
Authors: Cheng Yuanfang , Xue Mingyu , Shi Jihui , Li Yang , Yan Chuanliang , Han Zhongying , Yang Junchao
Published: March 2023

Natural gas hydrate has been identified as a new alternative energy resource which has characteristics of weak cementation, low reservoir strength and shallow overburden depth. Thus, the stability of subsea equipment and formation can be affected during the drilling process. To quantitative assessment on the vertical displacement of the strata induced by hydrate decomposition and clearly learn the influence laws of various factors on wellhead stability, this study established a fully coupled thermo-hydro-mechanical-chemical (THMC) model by ABAQUS. The important factor that affects the wellhead stability is the decomposition range of hydrate. Based on this, the orthogonal experimental design method was utilized to analyze the influence laws of some factors on wellhead stability, including the thickness of hydrate formation, initial hydrate saturation, overburden depth of hydrate sediment, and mudline temperature. The results revealed that, the decomposition of hydrate weakens the mechanical properties of the hydrate formation, thus leading to the compression of the hydrate formation, further causing the wellhead subsidence. The factors were listed in descending order as follows according to their significance of influences on wellhead stability: the thickness of hydrate formation, initial hydrate saturation, overburden depth of hydrate sediment, and mudline temperature. In particular, the effect of mudline temperature on wellhead stability is negligible. Hence, these findings not only confirm the influence of hydrate decomposition on wellhead stability, but also provide important implications for the drilling of hydrate-bearing strata.
Bioinformatics for Wet-lab Scientists: Practical Application in Sequencing Analysis
Authors: Laub Vera , Devraj Kavi , Elias Lena , Schulte Dorothea
Published: March 2023

Background
Genomics data is available to the scientific community after publication of research projects and can be investigated for a multitude of research questions. However, in many cases deposited data is only assessed and used for the initial publication, resulting in valuable resources not being exploited to their full depth.
Main
A likely reason for this is that many wetlab-based researchers do not apply bioinformatic tools themselves and therefore lack the necessary expertise. In this article, we present a series of freely available, predominantly web-based platforms and bioinformatic tools that can be combined in analysis pipelines to interrogate different types of next-generation sequencing data. Additionally to the presented exemplary route, we also list a number of alternative tools that can be combined in a mix-and-match fashion. We place special emphasis on tools that can be followed and used correctly without extensive prior knowledge in programming. Such analysis pipelines can be applied to existing data downloaded from the public domain or be compared to the results of own experiments.
Conclusion
Integrating transcription factor binding to chromatin (ChIP-seq) with transcriptional output (RNA-seq) and chromatin accessibility (ATAC-seq), can assist to form a deeper understanding of the molecular interactions underlying transcriptional regulation and will help establishing new hypotheses and pre-testing them in silico.