bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase 2a study evaluating the efficacy and safety of sutetinib in patients with advanced non–small-cell lung cancer (NSCLC) harboring uncommon EGFR mutations.
Authors: Wu Fengying , Zhou Fei , Zhao Fuyou , Zhang Wei , Wang Lei , Yu Jia , Xiong Anweng , Zhao Jing , Li Wei , Gao Guanghui , He Yayi , Bo Bing , Meng Shuyan , Han Baohui , Zhou Caicun
Published: June 2023

9131

Background: Although non-small cell lung cancer (NSCLC) patients with tumor harboring classical Epidermal Growth Factor Receptor (EGFR) mutations have numerous therapeutic choices, uncommon EGFR mutation NSCLC patients have limited treatment options. Sutetinib is a selective tyrosine kinase inhibitor (TKI) targeting uncommon EGFR mutations. Methods: In this multicenter, open-label phase 2a study, treatment-naïve adults with NSCLC harboring uncommon EGFR mutations (G719X, S768I, L861Q) received oral sutetinib monotherapy at 80 or 64 mg/day (Chinese trial register CTR20190681). The primary endpoint was objective response rate (ORR) per RECIST v1.1. Secondary endpoints included duration of response (DoR), overall survival (OS), safety and tolerability. Adverse events (AEs) were graded according to the CTCAE v5.0. Results: Sutetinib was administered to 30 NSCLC patients at 80 (n = 15) or 64 (n = 15) mg/day. Median age was 60 years old (range 47-74 years). Twenty patients (66.7%) were females, 10 patients (33.3%) had a history of smoking. Patients had an ECOG PS of 0 (10.0%) or 1 (90.0%). Tumors had a G719X (36.7%), L861Q (30.0%), or S768I (20.0%) EGFR mutation, or a combination of these uncommon EGFR mutations (13.3%). None had EGFR T790M, L858R, exon 19 deletions, or exon 20 insertions. The ORR was 71.4% (20/28), including 92.9% (13/14) and 50.0% (7/14) in the 80 and 64 mg/day cohorts, respectively. The disease control rate (DCR) was 96.4%, including 100.0% (14/14) and 92.8% (13/14) in the 80 and 64 mg/day cohorts, respectively. All responses were partial responses. The median DoR was 12.5 months (20.3 and 9.2 months in the 80 and 64 mg/day cohorts, respectively). One-year OS was 84.7% (92.9% and 75.0% in the 80 and 64 mg/day cohorts, respectively). As of 15 January 2022 (database lock), 11 (36.7%) patients were still receiving sutetinib treatment. Grade ≥3 treatment emerged AEs were similar in the 80 mg/day (80.0%, 12/15) and 64 mg/day (73.3%, 11/15) cohorts. The most frequently reported grade ≥3 Treatment-related AEs (TRAEs) were diarrhea (36.7%), abnormal liver function (13.3%), and rash (10.0%). One grade 4 TRAE was observed: hypokalemia in the 64 mg/day cohort. Conclusions: Sutetinib demonstrated a high response rate with durable antitumor activity in patients with NSCLC harboring uncommon EGFR mutations. The toxicities are expected and comparable to other EGFR TKIs. A multi-center phase 2b study is ongoing in the United States and China to further evaluate Sutetinib in uncommon EGFR mutation NSCLC. Clinical trial information: CTR20190681 .
Metformin with neoadjuvant chemotherapy in localized triple negative and HER2neu-positive breast cancer: A prospective phase 2 open label randomised controlled trial (McBETH).
Authors: B M Mouna Bidaraguppe , kumar akash , Batra Atul , Sharma Vinod , Kataria Babita , Gogia Ajay , Mathur Sandeep , Sharma Aparna
Published: June 2023

TPS631

Background: Repurposing of drugs in cancer is an attractive strategy and metformin has long been an agent with promising yet unproven activity in breast cancer. Despite some recent studies showing inadequate efficacy in adjuvant setting, there is a lack of well powered studies in neo-adjuvant setting in localised breast cancer. Few past studies suggest that metformin may have anticancer effects in the subsets of Her2 neu positive as well as Triple negative breast cancer (TNBC). We initiated this study to investigate if metformin in combination with standard neo-adjuvant chemotherapy is effective in improving pathological complete response rates in these subsets among localised breast cancers. Methods: This is an investigator initiated randomised, open label, parallel-group superiority trial. All non diabetic localised chemo-naïve breast cancer patients aged ≥18 years planned for neo-adjuvant chemotherapy will be randomly allocated (stratified by HER 2 positive and TNBC) to receive standard neo-adjuvant chemotherapy with or without metformin (850mg twice daily) till the day of surgery. The patients will be followed up until the surgery. The primary objective of this study is to compare the pathological complete response rates(ypT0ypN0) in each arm. The secondary objectives are to compare pathological complete response rates in predefined subsets of HER2 positive and triple negative breast cancer, clinical response rates in each arm, patient reported outcomes in each arm (ESAS-r Scale), breast conservation surgery rates in each arm, incidence and severity of adverse events in both arms. Trial statistical design: Planned accrual is total 242 patients including 10% drop out rate. It is a superiority design with an absolute improvement of 11% in pathological complete response from a baseline of 33% in the standard arm. Conduct to date: study activation: May 2022. Enrolment: 116 subjects. Clinical trial information: REF/2022/05/054208.
Dexamethasone and exercise for cancer-related fatigue: A phase III randomized controlled trial.
Authors: Noronha Vanita , Goud Supriya , Mahajan Sarika Gautam , Sharma Rangita , Yadav Akanksha , Pawar Akash , Chintala Sravan Kumar , Shah Minit Jalan , More Sucheta Bhagwan , Menon Nandini Sharrel , Patil Vijay Maruti , Singh Ajaykumar Chandrabhan , Shah Srushti , Nawale Kavita Prakash , Nakti Dipti , Daptardar Anuradha , Karuvandan Naveen , Sarkar Laboni , Suman Mannavi , Prabhash Kumar
Published: June 2023

LBA12098

Background: Cancer-related fatigue (CRF) significantly impacts QoL of patients. Dexamethasone with physical activity may improve CRF. Methods: Phase III randomized study in patients with advanced cancer on palliative intent therapy, with ECOG PS 0-2, and fatigue score > 4/10 on numeric rating scale. Intervention included oral dexamethasone 8 mg twice daily for 7 days, and exercise (aerobic + resistance). Results: From Dec 2022 to Feb 2023, we enrolled 114 pts; 56 in intervention arm, and 58 in standard arm. Median age was 56 yrs (IQR, 47.8 to 65), with 74 (64.9%) males. Common tumors were lung (75, 65.8%), head-and-neck (12, 11%), and breast (10, 8.8%). Compliance was 87.3% (n=48) for dexa, and 70.9% (n=39) for exercise. Primary endpoint of mean improvement in FACIT-Fatigue subscale on day 8 was 3.22 (SD, 12.69) in intervention, compared to 1.73 (SD, 9.97) in standard arm; P =0.495. However, 54.5% patients in intervention had at least 3 points (minimal clinically relevant) decrease in fatigue, vs 41.8% in control; P=0.182. By day 29, mean change in FACIT-Fatigue scores compared to baseline was similar in intervention vs control; 2.61 (SD, 14.64) vs 2.68 (SD, 12.87), respectively; P=0.978. Although overall symptoms (ESAS) and general QoL were similar, there was a significant improvement in fatigue symptom on EORTC QLQ-C30 in intervention on day 29 compared to baseline; P=0.013. Sleep quality also significantly improved on Day 29 in intervention; P=0.018. On EORTC-QLQ FA12 (cancer-related fatigue QoL), physical fatigue improved significantly from baseline to Day 8 in intervention versus control; P=0.035; with no difference in emotional or cognitive fatigue, interference with daily life, or social sequelae. There was no difference in grade ≥ 3 adverse events between groups; 18 (32.7%) in intervention group versus 18 (30.5%) in control group; P=0.799. Conclusions: Dexamethasone and exercise did not lead to a statistically significant improvement in fatigue by FACT-Fatigue scale, although it resulted in greater proportion of pts with clinically relevant improvements in fatigue. The intervention significantly improved QoL fatigue symptom score and reduced physical fatigue on QoL, along with improving sleep quality. Clinical trial information: CTRI/2022/09/045678 . [Table: see text]
Pembrolizumab plus axitinib versus sunitinib as first-line therapy for advanced clear cell renal cell carcinoma: 5-year analysis of KEYNOTE-426.
Authors: Rini Brian I. , Plimack Elizabeth R. , Stus Viktor , Gafanov Rustem , Waddell Tom , Nosov Dmitry , Pouliot Frederic , Alekseev Boris , Soulieres Denis , Melichar Bohuslav , Vynnychenko Ihor O. , Azevedo Sergio Jobim , Borchiellini Delphine , McDermott Raymond S. , Bedke Jens , Tamada Satoshi , Wu Sterling , Burgents Joseph , Molife L. Rhoda , Powles Thomas
Published: June 2023

LBA4501

Background: At the first interim analysis of the randomized, open-label, phase 3 KEYNOTE-426 (NCT02853331) study, 1L pembro + axi showed statistically significant OS, PFS, and ORR over sun for advanced ccRCC. We report results with 5-y minimum follow-up. Methods: Adults with confirmed locally advanced or metastatic ccRCC with or without sarcomatoid features, no previous systemic therapy for metastatic ccRCC, KPS ≥70%, and ≥1 lesion measurable per RECIST v1.1 were randomly assigned 1:1 to receive pembro 200 mg IV Q3W for 35 doses (~2 y) + axi 5 mg PO BID or sun 50 mg PO QD on a 4-wk-on/2-wk-off schedule. Dual primary end points were OS and PFS per RECIST v1.1 by blinded independent central review (BICR). Secondary end points included ORR and DOR per RECIST v1.1 by BICR, and safety. A post hoc analysis adjusting for the effect of subsequent therapy on OS using a 2-stage adjustment model was conducted. Results: Of 861 enrolled patients (pts), 432 were assigned to pembro + axi and 429 to sun. Median study follow-up was 67.2 mo (range, 60.0-75.0). Efficacy for the ITT population and IMDC risk subgroups are shown in table. For pembro + axi vs sun, the 60-mo OS rates were 41.9% vs 37.1%, and the 60-mo PFS rates were 18.3% vs 7.3%. Median DOR (range) was 23.6 mo (1.4+ to 68.6+) for pembro + axi and 15.3 mo (2.3-68.3) for sun. In pts who discontinued treatment, 237/381 pts (62.2%) in the pembro + axi arm and 300/406 pts (73.9%) in the sun arm received subsequent anticancer treatment. The HR for OS when adjusted for subsequent therapy was 0.67 (95% CI, 0.52-0.84). Clinical data on pts who completed 2 y of pembro will be presented. No new safety signals were observed. Conclusions: After 5 y of follow-up, pembro + axi had sustained OS, PFS, and ORR benefits over sun in advanced ccRCC. These results are the longest follow-up to date of an anti–PD-1/L1 inhibitor + VEGFR TKI in this pt population and continue to support the use of pembro + axi as a 1L standard of care for advanced ccRCC. Clinical trial information: NCT02853331 .
Art on Film at Finch College: Reproductive Labor in the Enrichment Economy
Authors: Ridlen Tim
Published: June 2023

Finch College was a small women's liberal arts college located on the Upper East Side of Manhattan open from 1900 to 1975. The Contemporary Wing of the Finch College Museum of Art held a number of important exhibitions for conceptual art, experimental media, and film organized by the museum's curator, Elayne Varian, from 1966 to 1975. This article addresses how ideas of process, reproduction, and documentation were being reconfigured at Finch, especially in film and media art of the 1960s. Robert Morris's film installation, Finch College Project (US, 1969), is emblematic of this larger turn toward process in the visual arts; however, Varian's Projected Art exhibitions complicate our understanding of how and why artistic process became a subject of interest. In light of what Boltanski and Esquerre have recently identified as an “enrichment economy” and what feminist thinkers of the time theorized as reproductive labor, works in the Projected Art series shift attention to the reproductive labor of caring for, curating, collecting, and consuming visual art and film. I argue that Varian's exhibitions as a whole complicate our understanding of process-oriented work during the postwar period, especially film and media that moved into gallery exhibition spaces. These works attacked the existing modes of production by turning toward process, complicating the status of photographic reproduction, and contributing their own surplus value through reproductive labor.
Critical Hope
Authors: Kesrouany Maya Issam
Published: June 2023

This article explores the theory and practice of critique in the works of the Lebanese Communist intellectual Husayn Muruwwa (1910–1987) and his grandson Rabih Mroué (b. 1967). Husayn Muruwwa, one of the most important Arab intellectuals of the second half of the twentieth century, reinvented literary criticism and cultural critique in the 1950s and '60s. His grandson, one of the most prominent Arab visual artists, has been redefining the critical approach to visual representation since the Lebanese civil war. The article pits Husayn Muruwwa's critique based on collective hope and emancipation against his grandson's vision of an individualistic critique based on desire. It considers the critical and political writings of Husayn Muruwwa and Rabih Mroué's performances, video lectures, and interviews to explore specifically how they represent hope in relation to critique, and it ultimately suggests a participatory aesthetics that is common to both and that transcends their autobiographical statements and establishes resonances between their thought. Their approaches to critique, the article illustrates, play out as revised inheritances of both the Arab renaissance (nahda) and the national liberation movements in the 1970s. These revisions create a continuity that is critical to understanding the relationship between critique and hope in the Arab intellectual tradition.
Tetracycline-mediated fluorescence correlates with passage number and β-galactosidase activity in HeLa and HEK293T cells
Authors: Redwood-Sawyerr Chileab , Nesbeth Darren N.
Published: June 2023

We report data consistent with tetracycline-mediated fluorescence having the potential to be an effective marker of senescence in immortalised cells. HeLa cells that had previously undergone more than 20 passages were transiently transfected with a plasmid encoding a novel tetracycline-inducible transgene featuring an open reading frame for green fluorescent protein. While characterising the performance of this plasmid and transfection procedure, HeLa cell fluorescence was observed to result from incubating cells with media containing 2 μg/ml tetracycline alone, without plasmid or transfection reagent. To investigate this phenomenon further, HeLa and HEK293T cells were purchased from a tissue culture collection and after cultivation over 4-23 passages, incubated with media containing 2 μg/ml tetracycline. For both cell lines, tetracycline-mediated fluorescence increase correlated with passage number increase. This effect in HeLa and HEK293T cells was also borne out by expression of β-galactosidase activity, an imperfect but widely used marker of cellular senescence. These data suggest tetracycline may have utility as a marker of cellular senescence in immortal cells and can inform future investigation and validation of this previously unreported application for this reagent.
Από τον αγροτικό στον αστικό χώρο
Authors: Χρονοπούλου Χριστίνα
Published: June 2023

Η παρούσα διατριβή επικεντρώθηκε στη μελέτη των λογοτεχνικών χαρακτήρων στα διηγήματα του Δημοσθένη Βουτυρά. Πιο συγκεκριμένα, το ερμηνευτικό ενδιαφέρον στράφηκε στους χαρακτήρες του κοινωνικού περιθωρίου, όπως αυτοί αποτυπώνονται σε διηγήματα που καλύπτουν χρονικά μια περίοδο από την αρχή της συγγραφικής παρουσίας του λογοτέχνη ως τα μέσα της μεσοπολεμικής περιόδου. Μεθοδολογικά η διατριβή αναπτύχθηκε αξιοποιώντας κειμενικά και εξωκειμενικά κριτήρια, με ερμηνευτικά εργαλεία από την αφηγηματολογία αλλά και το επιστημονικό πεδίο της κοινωνιολογίας. Πιο ειδικά, θεωρητικές πυξίδες αποτέλεσαν, η αφηγηματολογική προσέγγιση βάσει του ευρύτερου θεωρητικού σχήματος του Gerard Genette και η τυπολογία της Dorrit Cohn για τη μελέτη της συνείδησης των μυθοπλαστικών προσώπων σε μια πιο υφολογικού τύπου ανάλυση, ενώ σημαντικά ευρήματα για την αποτύπωση των χαρακτήρων αναδύθηκαν από την αξιοποίηση της θεωρίας του Bakhtin για τη διαλογικότητα και των συμπερασμάτων του σχετικά με το καρναβαλικό στοιχείο. Επιπλέον, η προσέγγιση της συμπεριφοράς και της ταυτότητας των περιθωριακών χαρακτήρων όπως τους αποδίδει ο συγγραφέας έγινε μέσω των πολιτισμικών σπουδών και ειδικότερα των θεωρητικών μελετών του Pierre Bourdieu, αναφορικά με τα μοντέλα ζωής της λαϊκής τάξης. Για την κατηγοριοποίηση των χαρακτήρων χρησιμοποιήθηκε κυρίως το μοντέλο της Shlomith Rimmon – Kenan. Τα συμπεράσματα σχετικά με την απόδοση του κοινωνικού αποτυπώματος, των πολιτικών και φιλοσοφικών ιδεών, τοποθετούν τους χαρακτήρες του Βουτυρά στο φάσμα της ρεαλιστικής αφήγησης.
Exploring potential strategies to enhance memory and cognition in aging mice
Authors: Bhat M Shreevatsa , M G Ramesh Babu , Dhanushkodi Anandh , Rai Prof Kiranmai S
Published: June 2023

Background: Aging population is rapidly expanding worldwide, and age-related cognitive impairments prove detrimental for achieving a better productive and quality of life.  Lack of effective therapies for age-related cognitive impairment focuses attention on developing preventive strategies, such as nutritional interventions, cell therapies and environmental manipulations. The objective of the present study was to explore the comparative benefits of potential memory-enhancing strategies like supplementation of choline (Ch) and docosahexaenoic acid (DHA) or administration of human embryonic kidney stem cell conditioned media (HEK-CM) or exposure to environmental enrichment (EE), that attenuates cognitive impairments in aging mice.

Methods: 12-month-old CF1 male mice were subdivided [n=6/group] into normal aging control (NAC), saline vehicle control (SVC), Ch-DHA, EE, heat-inactivated HEK-CM (HIHEK-CM) and HEK-CM mice. Spatial working and reference memory were assessed using an eight-arm radial maze test and cognition using a novel object recognition test (NORT).

Results: Spatial memory and cognition were decreased in normal aging mice. Aged mice exposed to dietary Ch-DHA or HEK-CM showed significant enhancement in spatial learning tasks, memory and cognition compared to the same in age-matched NAC mice. Ch-DHA and HEK-CM treated mice committed significantly lesser reference memory errors and attained a higher percentage of correct choices in spatial learning and memory tasks. Moreover, on testing for cognition in NORT, significantly higher number of visits to the novel object was observed in Ch-DHA supplemented and HEK-CM administered aging mice whereas HEK-CM and EE mice groups showed significantly greater number of visits to familiar object, when compared to same in age-matched NAC and HIHEK-CM groups, respectively.

Conclusion: Supplementation of Ch-DHA and HEK-CM treatment strategies have a higher potential [~ 20—30%] for enhancing spatial learning, memory and cognition in normal aged mice, whereas exposure to EE seems to enhance only their short-term memory.
The journey of F1000Research since inception: through bibliometric analysis
Authors: Kumar Dilip , Shandilya Abhinav Kumar , Srivastava Sandeep
Published: June 2023

Background: Bibliometric analysis is an approach adopted by researchers to understand the various analytics such as year-wise publications, their citations, most impactful authors and their contributions, identification of emerging keywords, multiple themes (niche, motor, basic, and emerging or declining) etc. F1000Research is one of the Q1 category journals that publishes articles in various domains, but a detailed journal analysis is yet to be done.

Methods: This study is an effort to extract the F1000Research journey information through bibliometric analysis using VOS-viewer and Biblioshiny (R-studio) interface. The F1000Research journal started its journey in 2012; since then, 5767 articles have been published until the end of 2022. Most of the published articles are from medical science, covering Biochemistry, Genetics & Molecular Biology, Immunology & Pharmacology, Toxicology & Pharmaceutics. To understand the research journey, various analyses such as publication & citation trends, leading authors, institutions, countries, most frequent keywords, bibliographic coupling between authors, countries and documents, emerging research themes, and trending keywords were performed.

Results: The United States is the biggest contributor, and COVID-19 is the most commonly occurred keyword.

Conclusions: The present study may help future researchers to understand the emerging medical science domain. It will also help the editors and journal to focus more on developing or emerging areas and to understand their importance towards society. Future researchers can contribute their quality research studies, focusing on emerging themes. These authors’ research can guide future researchers to develop their research area around the most impacted articles. They can collaborate with them to bring that emerging theme forward.
How blue light affect sleep
Authors: Mikulska Julia , Skoczylas Kamila , Rokicki Sebastian , Schok Katarzyna
Published: June 2023

Many external factors affect human sleep. One of them is visible light. Its effect on the human body consists in synchronizing the biological clock in the suprachiasmatic nuclei of the hypothalamus with the 24-hour solar cycle. The short fraction of light waves perceived by humans as blue waves is the strongest factor that synchronizes the circadian system, which maintains the internal homeostasis of many biological and psychological rhythms. This impact depends on the amount, duration and time of exposure to blue light during the day. Exposure to blue light during the day is important for inhibiting the secretion of melatonin, a hormone produced by the pineal gland and playing a key role in entraining the circadian rhythm. While exposure to blue light is essential for maintaining the body's well-being, alertness, and cognitive abilities during the day, chronic exposure to low-intensity blue light right before bedtime can have serious consequences for sleep quality, circadian phase, and cycle duration. That is why the right amount and the right time of exposure to blue light are so important.
impact of ultraviolet radiation on the skin and the role of photoprotection – the review of the literature
Authors: Antonik Dominika , Denys Barbara , Góra Karolina , Zdziennicki Wojciech , Zimnicki Patryk , Lato Marta , Iberszer Konrad , Litwiniuk Maria , Zaniuk Marcin , Hurkała Kamil
Published: June 2023

Introduction and objective:

The sun emits ultraviolet radiation in the UV-A, UV-B and UV-C ranges. Photoprotection is used to prevent the impact of this radiation on the skin. It effectively counteracts photoaging, photodermatoses and photocarcinogenesis.

The aim of the study is to discuss the impact of UV radiation on the skin and the role of sun protection, also in special groups of patients - children and non-immunocompetent people. The article also presents a summary of data on the effect of sunscreens on vitamin D synthesis.

Materials and methods:

The literature was reviewed in the Pubmed, Google Scholar database and in the recommendations of the Polish Dermatological Society with the use of keywords.

State of knowledge:

Erythema is the most visible effect of sunburn, but exposure to UV radiation is primarily photocarcinogenesis or photoimmunosuppression. The SPF factor is the main determinant of the effectiveness of sunscreens, but effective protection against both UVB and UVA radiation is essential. Daily use of sunscreen reduces skin damage associated with exposure to light and does not negatively affect vitamin D synthesis.

Conclusions:

The basis of skin protection is using sunscreens, avoiding excessive exposure to solar radiation and using protective clothing, hats and sunglasses. Thanks to these activities, we can significantly reduce the number of cases of certain skin cancers. It is also important to remember that sun protection applies to everyone, especially children and non-immunocompetent people.
Intermittent fasting – a novel approach to treating overweight and obesity? – meta-analysis and literature review
Authors: Lubczyńska Zuzanna , Popravko Yevheniia , Lewandowski Mateusz Mirosław , Bienia Grzegorz , Żołnierek Maja , Świętochowski Jakub , Siekierko Nikola , Kotusiewicz Wiktoria , Jędrzejewska Barbara , Kotulska Maria
Published: June 2023

Introduction Intermittent fasting (IF) is a form of dietary intervention that includes periods of regular calorie intake alternated with periods of fasting. IF has gained a lot of attention as a potential approach to treating metabolic syndrome-related diseases. Therefore, health care professionals need to be able to provide their patients with evidence-based information on IF. The aim of this article is to review data on effectiveness of IF in weight loss, especially in comparison with calorie restriction.

MethodsPubMed and Google Scholar databases were searched for studies published from 1.01.2017 to 31.12.2022 that included phrases “intermittent fasting” or “alternate day fasting”, “intermittent fasting obesity”, “alternate day fasting obesity”. Intervention studies on obese or overweight patients were included. We excluded studies of short duration and studies that focused on intercurrent medical conditions. In total, 14 articles that suited those criteria were identified.

ResultsIntermittent fasting induces pronounced metabolic changes in the body due to strict and time-limited restriction of calorie intake and in animal models was proved to prolong lifespan and modulate tumorigenesis and aging. It is a proposed new approach to treating obesity, which is a a major risk factor for cardiovascular diseases and diabetes.

ConclusionsIn our study, IF was found as effective, but not superior to calorie restriction in reducing body mass, improving body composition and reducing other cardiometabolic risk factors. Our findings are consistent with other recent systematic reviews. Further research is needed to directly compare various IF regimens and determine patients’ characteristics that may be associated with more successful implementation of intermittent fasting regimens.
Teletrabajo y comportamiento creativo. El efecto moderador de la motivación intrínseca
Authors: Santiago-Torner Carlos
Published: June 2023

El teletrabajo es un recurso laboral que, con ciertas adaptaciones, puede actuar como un agente de bienestar emocional, regular el conflicto trabajo-familia y activar procesos organizacionales clave como la motivación intrínseca y el comportamiento creativo. Esta investigación tiene como objetivo principal estudiar la relación entre el teletrabajo y el comportamiento creativo, analizando el papel moderador de la motivación intrínseca entre esas dos variables. El modelo se contrasta a partir de una muestra compuesta por 273 hombres y 175 mujeres con estudios universitarios. El teletrabajo y su intensidad se relacionan de forma curvilínea con la motivación intrínseca y el comportamiento creativo. No obstante, el diseño de la curva no adquiere una forma de U invertida; es decir, el número de días teletrabajados y sus beneficios asociados, al progresar, no disminuyen gradualmente la motivación intrínseca y la creatividad del empleado. Así mismo, el teletrabajo y sus ventajas estimulan el comportamiento creativo solo cuando la motivación intrínseca alcanza niveles medios o altos. Sin duda, el teletrabajo se convierte en un hábitat idóneo para empleados con alta formación académica, pues integra necesidades psicológicas básicas que explican el modo en que la motivación intrínseca se asocia con algunos rasgos de la personalidad; además, este vínculo produce respuestas novedosas, útiles y adaptativas. Sin embargo, la eficacia del teletrabajo y el evitar el aislamiento social es una responsabilidad compartida que requiere un esfuerzo ininterrumpido entre organización y empleado.
Making something out of nothing! Creating art using recycled materials in early years
Authors: Rana Priyanka
Published: June 2023

Art Specialist, Priyanka Rana, discusses the importance of giving little children the opportunity to develop their creative skills as well as learn about sustainability and environmental concerns in an age appropriate way, in time for Children's Art Week from the end of June into July. Priyanka shares ideas for how settings can easily take part without spending lots of money on art supplies.
Dyslexia and technology
Authors: Worsdell Chantal
Published: June 2023

Chantal Worsdell considers the pros and cons of cutting-edge technology for dyslexia diagnosis/support, and whether concepts of embodied cognition can help ECEC settings embrace technological innovation.
Selecting your next device
Authors: Bird Vanessa
Published: June 2023

With a myriad of choices on the market, selecting devices for your clinic can be a highly stressful process. Aesthetic consultant Vanessa Bird sheds light on aspects to consider when making these important technical purchases for your clinic
İLK TÜR NEOLİTİK ÇÖMLEKÇİLİKTEN ÜÇ BOYUTLU YAZICILARLA SERAMİK ÜRETİMİNE
Authors: ÜNAL Serap , HASEKİOĞLU Uygar
Published: June 2023

Birinci tür çömlekçilik olarak adlandırılan, elle şekillendirmede yaygın olarak kullanılan, formu fitil tekniği ile yükselterek oluşturma yöntemi, günümüzde de aynı zamanda önemli bir kültürel değer olarak sürdürülmektedir. Bu tarz üretimin ilk ustasının günümüzden 50-60 milyon yıl önce varlığı ön görülen çömlekçi yaban arısı olduğu da göz ardı edilmemelidir. Aynı zamanda bu yöntem çağdaş teknolojilere de esin vermiştir. Üç boyutlu yazıcılarda polimer ve toprak malzemelerle üretilen formların teknolojik temelde çıkış noktası birinci tür ilkel çömlekçiliktir. Çömlek üretiminin makine destekli gelişimi; çarklı çömlekçilikten itibaren, günümüzün inovatif üretim teknolojileri arasında önemli bir yer tutan 3B bilgisayar destekli yazıcılarla yapılan üretim tarzına ve daha da ileriye dönük bir gelişim içinde Delta Wasp sistemiyle mimaride konut yapımına kadar taşınmıştır.

Çalışmada, yaklaşık 9000 yıllık pişmiş toprak üretimi ve kültürü olan çömlekçiliğin değerli bir maddi kültür unsuru olduğu vurgulanmış, çağdaş seramik endüstrisi ve sanatına ilham veren yansımaları incelenmiş, anılan biyomimetik ve tarihsel aktarımla birlikte, 3B yazıcılarla Göller Bölgesi killeri ile Tekstür profil analizi (TPA) yapılarak seramik üretimi ve uygulamaları hakkında bilgi üretilmesi amaçlanmıştır.

Anahtar kelimeler: Çömlekçilik, Kültürel Miras, 3B Seramik Üretimi, Tekstür profil analizi.
XRD Observation on the Weld Metal of Resurfaced Rail Steel
Authors:   Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand, Muangjunburee Prapas ,   Center of Excellence in Metal and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand, Poolsiri Nutchanon ,   Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand, Chaideesungnoen Sasirat ,   Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand,   Center of Excellence in Metal and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand, Naultem Ammarat ,   Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand, Oo Hein Zaw ,   Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand, Kongpuang Manwika ,   Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand,   Center of Excellence in Metal and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
Published: June 2023

The current research studied two samples of rail steel grade 900A deposited with different electrodes, namely, electrodes A and B, using the Shielded Metal Arc Welding (SMAW) process. This research fi nds out the suitable hardness values of the various electrodes. The phase identifi cation and microstructural analysis of weld metal were conducted using X-ray diffraction (XRD) and an optical microscope, respectively. The micro-hardness profi les along the cross-section of the weldment were acquired using a micro-Vickers hardness tester, and a Brinell hardness tester measured the hardness values on the top surface of the weld metal. According to the results, the diffraction angles of the XRD patterns for all weld metal samples differed due to their distinct microstructures. The microstructure of the weld metal, in particular, produced the primary infl uence on the hardness
A Comparison Between Position-Based and Image-Based Multi-Layer Graphical user Authentication System
Authors: Edward Audu Lovingkindness , Suru Hassan , Giro­ Mustapha Abubakar
Published: June 2023

System security is very important, especially in the age that we live in. One of the ways to secure data is by creating a password that makes it difficult for unauthorized user to gain access to the system. However, what makes it difficult for the system to be attacked is directly dependent on approach used to create it, and how secured it is. Text based approach is the oldest authentication approach. It requires that the user supplies textual password in order to gain access to the system. However, this approach has shown a significant drawback and several vulnerabilities, one of which is the difficulty in recalling or remembering textual passwords. Several other attacks that textual passwords are vulnerable to include brute force attacks, shoulder spying, dictionary attacks etc. The introduction of graphical schemes made things a lot better. Graphical passwords make use of images. However, most graphical schemes are vulnerable to shoulder surfing attacks. In this research work, we developed two systems; A position-based multi-layer graphical user authentication system and an Image-based multi-layer graphical user authentication system. The reason behind this research work is to compare the two systems, and evaluate them based on three major performance metrics: (1) Security, (2) Reliability (3) Individual preference.
A study on the characteristics of patients with facial palsy treated with Korean medicine - Based on the Korean National Health Insurance statistical yearbook
Authors: Yoon Hae-chang
Published: June 2023

Objectives: This study aimed to find out the characteristics of patients with facial palsy based on the National Health Insurance(NHI) statistical yearbook and provide the information pertaining to supplement Coverage of NHI.Methods: Based on the data of NHI between 2004 to 2021 for facial palsy(G51) obtained from the Ministry of Health and Welfare, the analyses were carried out according to the distribution of gender and the number of patients, visits, reimbursed days, and medical expenses by using the SAS 9.4.Results: The crude rate of facial palsy was reported as 361.71(2021) comparable with 419.60(2004) and 534.11(2009). The rate of men increased from 293.96(2004) to 302.27(2021) but the rate of women decreased from 450.88(2014) to 420.80(2021). The number of patients maintained around 190,000, however, it declined for patients treated Korean medicine(KM) after 2010. As the medical expenses were elevated, especially Western medicine(WM), that of WM exceeded KM’s since 2018. The expenses of women were higher than men’s in KM. By contrast, there was no difference with gender in WM. For reimbursed days per visits, it has been increased in WM but there was no difference in KM.Conclusion: Although the rate of patients with facial palsy in KM was high with no difference in the whole number of patients and reimbursed days per visits in KM annually, the number of patients in KM decreased but medical expenses elevated. According to this, it is necessary for reinforcing Coverage of NHI to research other factors related to KM.
Effects of Korean Medicine Treatment at Public Health Center for Post-acute COVID-19 Patients: A Retrospective Case-series of 11 patients
Authors: Yu Chang-hwan , Kim Kwan-Il , Jung Hee-Jae , Lee Beom-joon
Published: June 2023

Objectives: The purpose of this study is to determine the clinical features of post-acute COVID-19 syndrome and the effectiveness and safety of Korean medicine treatment at the Public health center.Methods: The study was conducted among 11 patients with post-acute COVID-19 syndrome who attended a single public health center from January to December 2022. We retrospectively analyzed the charts of 11 patients and collected clinical characteristics, previous treatments, Korean medicine treatments, outcome variables (Numeral Rating Scale (NRS), Leicester Cough Questionnaire (LCQ), Visual Analog Scale (VAS)), adverse events, etc.Results: Of the 11 patients, six were women, and the average age of all patients was 68.27±12.31 years. The most common symptom were cough(n=9, 81.82%) and sore throat(n=9, 81.82%), followed by sputum, fatigue, rhinorrhea, and loss of appetite, etc. All 11 patients were treated with herbal medicine, with Samso-eum(n=6, 54.55%), Yeonkyopaedok-san(n=5, 45.45%), and Haengso-tang(n=3, 27.27%) being the most commonly used. After herbal medicine treatment, the median cough NRS decreased from 5 to 1, and the median sore throat NRS decreased from 4 to 1, both of which were statistically significant. One patient reported adverse event of dyspepsia and heartburn, but it was mild.Conclusions: The study presented the clinical features of the post-acute COVID-19 syndrome and suggested that Korean medicine treatment at public health centers may be effective and safe in alleviating associated symptoms.
A Case Report of Acute Angle Closure Glaucoma Patient Treated with Go-bang
Authors: Han gioen , Kang Eunjeong
Published: June 2023

Objectives: This is a case report on the treatment of one patient with acute angle-closure glaucoma using traditional Korean medicine.Methode: We assessed the progression of acute angle-closure glaucoma by analyzing Optical Coherence Tomography(OCT) results.Results: Acute angle closure glaucoma did not progress to OCT after treatment.Conculsion: We obtained results from OCT examinations indicating that the progression of acute angle-closure glaucoma had ceased after Korean herbal medicine treatment.
Effects of Bojungikgi-tang and its modifications for Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Kim Mikyung , Han Chang-ho
Published: June 2023

Objectives: This study aimed to evaluate the efficacy and safety of Bojungikgi-tang (BJIG) and its modifications for patients with anemia.Methods: The subject of analysis of this study was a parallel design randomized controlled trial in which BJIG or its modifications was administered orally to patients who met the World Health Organization's anemia criteria and the efficacy and safety were prospectively measured. Electronic databases were searched to retrieve eligible literature published from 1 January 2000 to 12 February 2023. A meta-analysis was conducted, and the risk of bias (RoB) and level of evidence of the included studies was assessed using the Cochrane RoB 2 tool and GRADE method, respectively.Results: Five studies were included in the meta-analysis. When BJIG or its modifications was administered to anemia patients receiving conventional treatment, additional benefits compared to the non-administered group were found in terms of an increase in red blood cell count (mean difference (MD) 0.46 x 1012/L, 95% confidence interval (CI) 0.17 to 0.74), hemoglobin concentration (MD 9.28 g/L, 95% CI 6.06 to 12.51), hematocrit (MD 2.57%, 95% CI 1.76 to 3.38), total effective rate (odds ratio 5.29, 95% CI 2.05 to 13.68), and traditional Chinese medicine symptom scores (standardized MD -1.51, 95% CI -2.79 to -0.24).Conclusions: This study demonstrated the clinical potential of BJIG and its modifications to provide additional benefits to patients with anemia receiving conventional treatment.
The First Record of Calvolia summersi (Mostafa, 1970) (Acari: Winterschmidtiidae) from the Oriental Region and a new record of host association with Xylocopa (Ctenoxylocopa) fenestrata (Fabricius, 1798) with a review on Xylocopa-mite associations in India
Authors: Ghosh Dibyajyoti , Acharya Shelley , Subramanian Kumarapuram A.
Published: June 2023

Mites have long been associated with bees, often showing a close relationship with particular taxa, probably due to a co-evolutionary process. The present study is the first confirmation on the occurrence of the mite species Calvolia summersi (Mostafa, 1970) in India and its association with Xylocopa fenestrata (Fabricius, 1798), a large carpenter bee species. The mite species was previously reported from Brazil in association with Zethus, a neotropical potter wasp genus. C. summersi is isolated and studied from different populations of X. fenestrata in Sagar Islands, West Bengal, the biggest island of mangrove Sundarban deltaic complex. A literature-based review of the Xylocopa-mite associations from India is provided herewith to understand the diversity and pattern of mite species on Xylocopa host selection in the country. Instigating a baseline study of Xylocopa-mite association is recommended to demark the status of dynamism for better conservation and protection.
Presidents in deficit: are there historical rewards to deficits?
Authors: Geloso Vincent , Shera Marcus
Published: June 2023

Buchanan and Wagner pointed to an asymmetry in the political rewards of deficits and surpluses, with the former being preferable to the latter. They assigned the rise of this asymmetry to the popularization of Keynesian ideas. We test both claims by relying on the historical reputation surveys of US presidents since 1948. Historical reputations have long been something presidents have cared about, and they constitute a reliable way to assess whether their reputations suffer or gain from having run deficits. We find evidence that the size of deficits tends to be associated with greater presidential scores and that this effect is stronger in more recent surveys, when Keynesian ideas were more popular.
Man's last stand! Polysemy and dialogue in advertising reception
Authors: Knudsen Gry Høngsmark
Published: June 2023

This paper examines the reception to an ad on YouTube, showing how users negotiate and challenge an ad's meaning in dialogue with other users, texts, and the persuasive intent of the ad. The ads, user comments, and video responses are analyzed through a combined netnography and discourse analysis. The analysis shows how polysemy is an aspect of the reading process and not an outcome of a more or less loyal acceptance of ad meaning. Thus, this study gives evidence that supports rhetorically oriented advertising theories.
"There Are No Ugly Women, Only Lazy Ones": Taiwanese Women's Social Comparison with Mediated Beauty Images
Authors: Tsai Wan-Hsiu Sunny
Published: June 2023

This qualitative interview study examines women's consumption of beauty media and their social comparison with mediated beauty images in relation to the motives of self-evaluation, self-improvement, and self-enhancement, in a collectivistic Asian society, Taiwan. This study pays special attention to how local media conventions and social norms frame women's relationship s with different types of beauty images. Respondent interviews were conducted with 35 Taiwanese women from various backgrounds. Findings underscore the inspirational role and educational function of media and advertising images in inducing women to accept mediated beauty standards as attainable and empowering. Taiwanese women's consumption of beauty media was primarily motivated by self-improvement goals, which were reinforced by local social beliefs that normalized women's responsibility to beautify themselves, and in turn, legitimized the media's skewed beauty standard as a worthy ambition for women.
The Impact of Lowering the Payroll Tax on Informality in Colombia
Authors: Fernández Cristina , Villar Leonardo
Published: June 2023

In 2012, the Colombian Government reduced employer payroll contributions from 29.5 to 16.0 percent. Two years later, the informality rate had diminished by about 4.0 percentage points. This paper attempts to estimate how much of this reduction was due to the tax reform, isolating the impact of other macroeconomic variables. A natural approach to performing this task is to apply a difference-in-differences methodology using a household survey panel. Since the Colombian survey does not have a panel structure, we simulated one using a matching difference-in-differences methodology. According to the results, the tax reform is associated with a 4.8-percentage-point decrease in the informality of workers affected by the reform in the thirteen main metropolitan areas. This represents approximately half the reduction of the relevant informality rate during that period, affecting mostly salaried men and workers in general with low levels of education.
Deceleration in Female Labor Force Participation in Latin America
Authors: Gasparini Leonardo , Marchionni Mariana
Published: June 2023

After half a century of sustained growth, female labor force participation has decelerated in Latin America, especially among married vulnerable women. Based on a large database of microdata from household surveys, this paper documents this recent deceleration and provides evidence on the determinants. We argue that the fast economic growth experienced by the region in the 2000s was an important driving force: lower unemployment and higher earnings of male partners plus increased social assistance may have reduced the pressing need for vulnerable women to take low-quality jobs.
Camera spatial arrangement influence on reconstruction accuracy of chemiluminescence tomography
Authors: Wang Jia , Li Mingzhe , Guo Zhenyan , Wu Shenjiang , Li Dangjuan
Published: June 2023

Computed tomography of chemiluminescence (CTC) has been demonstrated to be a powerful tool for three-dimensional (3D) combustion visualization and measurement, in which the number of cameras and their spatial arrangement significantly impact the tomographic reconstruction quality. In this work, the relationship of the camera spatial arrangement and tomographic reconstruction accuracy is theoretically established based on two-dimensional (2D) and 3D Mojette transforms and their accurate reconstruction conditions. Numerical simulations and experiments were conducted to demonstrate the theories. The results suggest that the exact reconstruction conditions of the Mojette transforms can be used to determine the minimum number of cameras required for tomography reconstruction, and its achieved reliability can be used as an indicator to predict the reconstruction quality. Besides, the 2D coplanar semicircular configuration exhibits a better performance than that of the 3D non-coplanar arrangement. When the 3D non-coplanar arrangement is adopted, the cameras should be widely distributed in the hemispherical space. The related research provides a theoretical basis for the establishment of the CTC system and other tomography modalities.
Experimental generation of nondiffracting Mathieu beams using a thin-disk laser configuration
Authors: Aghbolaghi Reza , Charehjaloo Habib Sahebghoran , Daemi Mohammad Hossein
Published: June 2023

Nondiffracting modes were experimentally generated in an end-pumped thin-disk laser with a new kind of axicon-based stable laser resonator. The eigenvalue and eigenvector of the resonator were investigated based on the geometrical optics view. Ytterbium ions doped in the YAG crystal as an active medium were then utilized in this configuration. The experimental generation of the Mathieu–Gauss and Ince–Gauss modes was performed and also discussed during the thin-disk deformation.