bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients
Authors: Wu Yi-Ying , Wang Sheng-Huei , Wu Chih-Hsien , Yen Li-Chen , Lai Hsing-Fan , Ho Ching-Liang , Chiu Yi-Lin
Published: December 2020

COVID-19, caused by SARS-CoV-2, has rapidly spread to more than 160 countries worldwide since 2020. Despite tremendous efforts and resources spent worldwide trying to explore antiviral drugs, there is still no effective clinical treatment for COVID-19 to date. Approximately 15% of COVID-19 cases progress to pneumonia, and patients with severe pneumonia may die from acute respiratory distress syndrome (ARDS). It is believed that pulmonary fibrosis from SARS-CoV-2 infection further leads to ARDS, often resulting in irreversible impairment of lung function. If the mechanisms by which SARS-CoV-2 infection primarily causes an immune response or immune cell infiltration can be identified, it may be possible to mitigate excessive immune responses by modulating the infiltration and activation of specific targets, thereby reducing or preventing severe lung damage. However, the extent to which immune cell subsets are significantly altered in the lung tissues of COVID-19 patients remains to be elucidated.

This study applied the CIBERSORT-X method to comprehensively evaluate the transcriptional estimated immune infiltration landscape in the lung tissues of COVID-19 patients and further compare it with the lung tissues of patients with idiopathic pulmonary fibrosis (IPF). We found a variety of immune cell subtypes in the COVID-19 group, especially naïve B cells were highly infiltrated. Comparison of functional transcriptomic analyses revealed that non-differentiated naïve B cells may be the main cause of the over-active humoral immune response. Using several publicly available single-cell RNA sequencing data to validate the genetic differences in B-cell populations, it was found that the B-cells collected from COVID-19 patients were inclined towards naïve B-cells, whereas those collected from IPF patients were inclined towards memory B-cells. Further differentiation of B cells between COVID-19 mild and severe patients showed that B cells from severe patients tended to be antibody-secreting cells, and gene expression showed that B cells from severe patients were similar to DN2 B cells that trigger extrafollicular response. Moreover, a higher percentage of B-cell infiltration seems associated with poorer clinical outcome. Finally, a comparison of several specific COVID-19 cases treated with targeted B-cell therapy suggests that appropriate suppression of naïve B cells might potentially be a novel strategy to alleviate the severe symptoms of COVID-19.
Impact of disease stage and age at Parkinson’s onset on patients’ primary concerns: Insights for targeted management
Authors: Bhidayasiri Roongroj , Boonmongkol Thanatat , Thongchuam Yuwadee , Phumphid Saisamorn , Kantachadvanich Nitinan , Panyakaew Pattamon , Jagota Priya , Plengsri Rachaneewan , Chokpatcharavate Marisa , Phokaewvarangkul Onanong
Published: December 2020

Background

The concerns of people with Parkinson’s disease (PD) about their disease are often different from the objective clinical picture and subject to various influencing factors, including disease progression. Currently our understanding of these concerns is limited, particularly in Asian countries.

Methods

A 50-item survey on Parkinson’s Disease Patients’ Concerns (PDPC Survey) was developed by a multidisciplinary care team. The subjective greatest concerns (most commonly concerning symptoms) of patients at a specialist centre in Bangkok, Thailand, were explored and categorised according to disease stage and age at onset of PD.

Results

Data for 222 patients showed concerns varied widely. Motor symptoms giving the greatest concern were problems with walking and/or balance (40.5% of patients), while the most commonly concerning non-motor symptom (NMS) was constipation (41.0%). Patterns were observed amongst different patient subgroups. Early PD patients (H&Y stage 1) were more concerned about NMS than motor symptoms, while the reverse was true for advanced PD patients. Young-onset PD patients showed significantly greater concerns than typical-onset patients about motor symptoms relating to social functioning, working and stigmatisation, such as speech (p = 0.003).

Conclusions

This study, in an Asian patient cohort, provides an assessment of a wide range of PD patients’ concerns, encompassing not only motor symptoms and NMS, but also treatment-related adverse events, care in the advanced stage, and the need for assistive devices. Identifying the concerns of individual PD patients and implementing a patient-centred approach to care is critical to their wellbeing and optimal outcomes. The PDPC survey can help healthcare teams build a more accurate picture of patients’ experiences to inform clinical management.
Is microaggression an oxymoron? A mixed methods study on attitudes toward racial microaggressions among United States university students
Authors: Lui P. Priscilla , Berkley Shalanda R. , Pham Savannah , Sanders Lauren
Published: December 2020

To best understand the possible negative health and social consequences associated with racial microaggression, in-depth understanding of how people judge these events is needed. People of Color (POC) and White participants (N = 64) were recruited for a mixed-methods study that incorporated quantitative attitude ratings and focus group interviews. Participants read and discussed their attitudes toward five vignettes that reflected microassault, microinsult, and microinvalidation scenarios. Semantic differential ratings showed that participants judged microassaults to be most unacceptable, followed by microinsults and then microinvalidations. Using a grounded theory approach, our qualitative analysis of interview data revealed five thematic categories. First, participants judged receivers’ psychological harm to be a critical consideration for their attitudes toward microaggression scenarios; they discussed factors associated with individual differences in appraisals, prior exposures to discrimination, and sensitivity to race. Second, participants were less consistent in their opinion about the role of the deliverers’ intent on their judgment of microaggressions; many considered microaggression events to be results of deliverers’ cultural ignorance and racial insensitivity. Third, our analysis revealed the central importance of contexts that shaped participants’ attitudes toward microaggression. Fourth, participants also discussed the notion that receivers of microaggression were racist for calling attention to race issues. Finally, POC participants tended to relate to the vignettes and use their lived experiences to contextualize their opinions about racial microaggression. The current results raise concerns regarding the conceptualization and utility of the word “microaggression,” especially within the broader contexts of racism and major discrimination. Other empirical and practical implications are discussed.
CT texture analysis of mediastinal lymphadenopathy: Combining with US-based elastographic parameter and discrimination between sarcoidosis and lymph node metastasis from small cell lung cancer
Authors: Koda Eriko , Yamashiro Tsuneo , Onoe Rintaro , Handa Hiroshi , Azagami Shinya , Matsushita Shoichiro , Tomita Hayato , Inoue Takeo , Mineshita Masamichi
Published: December 2020

Objectives

To investigate the potential of computed tomography (CT)-based texture analysis and elastographic data provided by endobronchial ultrasonography (EBUS) for differentiating the mediastinal lymphadenopathy by sarcoidosis and small cell lung cancer (SCLC) metastasis.

Methods

Sixteen patients with sarcoidosis and 14 with SCLC were enrolled. On CT images showing the largest mediastinal lymph node, a fixed region of interest was drawn on the node, and texture features were automatically measured. Among the 30 patients, 19 (12 sarcoidosis and 7 SCLC) underwent endobronchial ultrasound transbronchial needle aspiration, and the fat-to-lesion strain ratio (FLR) was recorded. Texture features and FLRs were compared between the 2 patient groups. Logistic regression analysis was performed to evaluate the diagnostic accuracy of these measurements.

Results

Of the 31 texture features, the differences between 11 texture features of CT ROIs in the patients with sarcoidosis versus patients with SCLC were significant. Among them, the grey-level run length matrix with high gray-level run emphasis (GLRLM-HGRE) showed the greatest difference (P<0.01). Differences between FLRs were significant (P<0.05). Logistic regression analysis together with receiver operating characteristic curve analysis demonstrated that the FLR combined with the GLRLM-HGRE showed a high diagnostic accuracy (100% sensitivity, 92% specificity, 0.988 area under the curve) for discriminating between sarcoidosis and SCLC.

Conclusion

Texture analysis, particularly combined with the FLR, is useful for discriminating between mediastinal lymphadenopathy caused by sarcoidosis from that caused by metastasis from SCLC.
Reperfused hemorrhagic myocardial infarction in rats
Authors: Nair Anand R. , Johnson Eric A. , Yang Hsin-Jung , Cokic Ivan , Francis Joseph , Dharmakumar Rohan
Published: December 2020

Background

Intramyocardial hemorrhage following reperfusion is strongly associated with major adverse cardiovascular events in myocardial infarction (MI) patients; yet the mechanisms contributing to these outcomes are not well understood. Large animal models have been used to investigate intramyocardial hemorrhage, but they are exorbitantly expensive and difficult to use for mechanistic studies. In contrast, rat models are widely used to investigate mechanistic aspects of cardiovascular physiology, but a rat model that consistently recapitulates the characteristics of an hemorrhagic MI does not exist. To bridge this gap, we investigated the physiological conditions of MI that would create intramyocardial hemorrhage in rats so that a reliable model of hemorrhagic MI would become available for basic research.

Methods & results

Sprague-Dawley rats underwent either a 90-minute (90-min) ischemia and then reperfusion (I/R) (n = 22) or 30-minute (30-min) I/R (n = 18) of the left anterior descending coronary artery. Sham rats (n = 12) were used as controls. 90-min I/R consistently yielded hemorrhagic MI, while 30-min I/R consistently yielded non-hemorrhagic MI. Twenty-four hours post-reperfusion, ex-vivo late-gadolinium-enhancement (LGE) and T2* cardiac MRI performed on excised hearts from 90-min I/R rats revealed colocalization of iron deposits within the scarred tissue; however, in 30-min I/R rats scar was evident on LGE but no evidence of iron was found on T2* CMR. Histological studies verified tissue damage (H&E) detected on LGE and the presence of iron (Perl’s stain) observed on T2*-CMR. At week 4 post-reperfusion, gene and protein expression of proinflammatory markers (TNF-α, IL-1β and MMP-9) were increased in the 90-min I/R group when compared to 30-min I/R groups. Further, transmission electron microscopy performed on 90-min I/R myocardium that were positive for iron on T2* CMR and Perl’s stain showed accumulation of granular iron particles within the phagosomes.

Conclusion

Ischemic time prior to reperfusion is a critical factor in determining whether a MI is hemorrhagic or non-hemorrhagic in rats. Specifically, a period of 90-min of ischemia prior to reperfusion can produce rat models of hemorrhagic MI, while 30-minutes of ischemia prior to reperfusion can ensure that the MIs are non-hemorrhagic. Hemorrhagic MIs in rats result in marked increase in iron deposition, proinflammatory burden and adverse left—ventricular remodeling compared to rats with non-hemorrhagic MIs.
Alternative hybrid media in Greece: An analysis through the prism of political economy
Authors: Papadopoulou Lambrini
Published: December 2020

This article explores Greek alternative media, records their hybridity and analyses them under the prism of political economy. Drawing theoretically on researchers who emphasize the elusiveness and heterogeneity of alternative media and examining them on account of their ownership structures, production practices and media content, I propose their conceptualization as a vibrant organism in a constant dialectic relationship with mainstream media. These ‘alternative hybrid media’ may borrow people, ideas and practices from mainstream media, but they do not compromise their values for the pursuit of profit or political power. This article focuses on Efimerida ton Syntakton, the country’s first national cooperative newspaper, which emerged out of a collective of laid-off journalists and constitutes a representative example of the hybridity that characterizes the Greek alternative media ecosystem. Based on interviews with journalists and secondary data, this article aims to point to the defining characteristics of ‘alternative hybrid media’ and generate a deeper insight into the complex area of alternative media.
ROLE OF TRADITIONAL EMPLOYMENT OF TUVANS IN SOLVING THE LABOR MARKET PROBLEMS OF THE REGION: NEW APPROACHES
Authors: Kylgyday Ai-kys Chamdalovna
Published: December 2020

The present paper covers the historically traditional economic patterns developed in the regions with low urbanization. These patterns based on the Tuva’s materials are being analyzed as well as their role in solving the problems in the labor market. The strategic advantages of their clustering in the field of ethnic economy development, the prospects for their implementation in the context of increasing the economically sustainable rural areas of the region have been revealed.
Nemzetközi vállalatok országhatárokon átívelő belső kommunikációjának menedzsmentje
Authors: Borgulya Ágnes , Konczosné Szombathelyi Márta , Szondi György
Published: December 2020

A tanulmány célja a nemzetközi vállalatok nemzeti határokat átlépő belső kommunikációjának vizsgálata, azaz milyen stratégiákkal irányítják a vállalatok vezetői az eltérő szociokulturális környezetben folyó kommunikációt. A szerzők nemzetközi vállalatnak azokat tekintik, amelyek értékesítési divíziót, képviseleti irodát működtetnek országhatáraikon kívül, amelyeknek leányvállalataik vannak külföldön. "Standardizálás vagy differenciálás: nemzetközi nagyvállalatok magyarországi gazdálkodó egységeinek kommunikációja" témájú kutatásukban a Magyarországon leányvállalattal rendelkező nemzetközi vállalatokat vizsgálják. Különbséget tesznek a vállalaton kívüli (extern), valamint a vállalaton belüli (intern) nemzetközi kommunikáció között. A kutatás a vállalaton belüli nemzetközi kommunikációt vizsgálta, hangsúlyos kérdésköre a nemzetközi nagyvállalatok magyarországi gazdálkodó egységeikkel (leányvállalataikkal) folytatott kommunikációja. Módszerük a rendszerező szakértői interjú. A kis mintavételű kutatási projekt jellege modelltesztelő: Adler (1980), Perlmutter (1969) és Argenti (1994) modelljeit is figyelembe véve, Simone Huck (2005) standardizálás vs. differenciálás modelljét tesztelték. Azt tárták fel, hogy a nemzetközi nagyvállalatok magyarországi gazdálkodó egységeinek kommunikációja a standardizálás vagy a differenciálás modell, illetve e modellek vegyítése mentén leírhatók-e, vagyis modelltipikusak-e. Kutatásuk újdonságértékét az adja, hogy kevés irodalom foglalkozik a vállalat belső, de a külföldön működő egységek miatt mégis határokat átlépő kommunikációjával.
Grupo educativo como estratégia para prevenção do câncer do colo do útero: um relato de experiência
Authors: Luiz Franciane Silva , Caçador Beatriz Santana , Tavares Amanda Tamires Drumond Vilas Boas , De Lelis Giovane Cupertino
Published: December 2020

O câncer do colo uterino (CCU) é relevante causa de morbimortalidade, representando um importante problema de saúde pública. No Brasil, é a terceira causa de óbito por câncer entre as mulheres possuindo altas incidências, com diagnósticos tardios. Sabe-se, entretanto, que grande problema é a adesão das mulheres ao exame, seja por medo ou tabus inscritos na sociedade. Nesta perspectiva, várias estratégias vêm sendo adotadas para aumentar a adesão ao programa de rastreamento do CCU por meio do exame citopatológico do colo do útero, bem como o seguimento das mulheres com exames alterados. Assim, percebe-se a importância dos grupos educativos ao se constituir estratégia de sensibilização sobre a importância de aderir ao exame preventivo. Relatar a experiência de realização de grupo educativo como estratégia de prevenção do câncer de colo de útero. Trata-se de um relato de experiência da realização de um grupo educativo conduzido por 2 alunos e 1 docente em uma unidade básica de saúde do município de Viçosa-MG. O objetivo do grupo foi construir junto à comunidade, conhecimentos acerca dos fatores de risco, prevenção primária e secundária, realização do procedimento, sinais e sintomas e tratamento do CCU. Participaram do grupo 12 e o convite foi realizado pelas ACS as quais participaram da atividade que foi realizada na sala de espera a fim de captar mais pessoas para reflexão. Fez-se exposição dialogada sobre os fatores de risco para aquisição do HPV e sobre câncer de colo uterino. Utilizou-se problematização e explicação passo a passo das etapas do exame, com exposição dos materiais os quais podiam ser manuseados pelos participantes. Percebe-se que grupo educativo intensifica o vínculo entre o indivíduo e o profissional e permite um espaço para se tirar dúvidas seja no âmbito coletivo ou individual e principalmente reforçar a importância em se prevenir o CCU. O grupo educativo revela-se como potente estratégia de promoção da saúde e de prevenção do CCU, sendo importante para construção do conhecimento junto à comunidade, sensibilização e desconstrução de mitos e tabus que fragilizam a tomada de atitude da mulher no sentido de realizar o exame preventivo.
Trabalho interdisciplinar no contexto da prevenção do câncer do colo do útero
Authors: Riguete Thais Michele de Medeiros , Campos Angélica Atala Lombelo , Neves Felipe Silva , Tavares Ludmila Sathler , Matri Alessanda Bonato Beghini , Teixeira Maria Teresa Bustamante
Published: December 2020

O trabalho interdisciplinar é estruturado a partir da articulação dos diferentes saberes, tendo como desafio o diálogo e interação de conhecimentos para a resolução de problemas. A interdisciplinaridade busca romper a hiperespecialização e a fragmentação dos saberes, caracterizando-se pela intensidade de trocas entre os especialistas. Enfatiza-se a relevância das ações interdisciplinares direcionadas ao controle do câncer cervical, sendo este considerado o quarto tipo de câncer mais prevalente na população feminina, que pode ser detectado precocemente por meio do exame citopatológico do colo do útero. Tal procedimento deve ser realizado em mulheres com vida sexual ativa, entre 25-59 anos de idade, ao menos uma vez por ano, ou, após dois exames anuais consecutivos negativos, a cada três anos. Descrever a experiência interdisciplinar da busca ativa de mulheres participantes de uma coorte. Trata-se de um relato de experiência a respeito de um projeto interdisciplinar para o rastreamento do câncer do colo do útero, no qual a população-alvo foi constituída por 449 mulheres, entre 20-59 anos de idade, que em 2011 participaram da primeira abordagem de uma coorte de base populacional realizada no município de Juiz de Fora – MG. Foi organizada uma força tarefa, incluindo as participações da equipe da Unidade de Atenção Primária à Saúde da respectiva região contemplada, bem como de profissionais e discentes das áreas de enfermagem, nutrição e medicina. Após sucessivas reuniões com todos os envolvidos, traçou-se um plano de ação, incluindo: os mapeamentos da população e do território adscrito; a busca ativa das mulheres através de visitas domiciliares; o contato telefônico, a divulgação do projeto no bairro e a oferta de exames em dias e horários atípicos (no período noturno e aos finais de semana). Após 8 meses, 297 mulheres foram avaliadas, 97 mudaram de bairro, 15 estavam gestantes ou haviam retirado o útero e 27 se recusaram a participar da pesquisa. Atualmente, restam 11 mulheres que já foram convidas e agendadas mais de três vezes, mas ainda não atenderam ao recrutamento. O projeto permitiu a troca de conhecimento e experiência entre os membros da equipe acerca dos fatores associados ao desenvolvimento do câncer do colo do útero, e maior entendimento sobre a doença e sua prevenção. A elaboração de novas estratégias de ação para promoverem uma melhor adesão ao programa de rastreio só foi possível diante do trabalho interdisciplinar. A experiência da integração curricular e da articulação ensino-serviço-comunidade foi desafiadora, mas possibilitou a construção de práticas inovadoras e exitosas. A interdisciplinaridade foi de suma importância para traçar caminhos alternativos que possibilitaram a ampliação da cobertura de exames.
Contribuição da prática do canto coral para a formação interprofissional na área de saúde
Authors: Teixeira Rodrigo Andrade , Soares Francisco José Passos , Medeiros Mércia Lamenha , Austrilino Lenilda
Published: December 2020

O objetivo deste trabalho é relatar uma pesquisa que está sendo realizada no Mestrado Profissional Ensino na Saúde. Consta de reflexões sobre a implantação da educação interprofissional, tendo como ponto de partida o coral da instituição e sua contribuição para o desenvolvimento de habilidades e competências para a prática colaborativa em saúde. A indissociabilidade ensino, pesquisa e extensão, princípio que direciona o projeto pedagógico para os cursos das instituições públicas de ensino superior, aponta para a necessidade de utilizar espaços extencionistas como estratégia favorável ao processo ensino aprendizagem. Assim, o Coral Extencionista da UNCISAL, constitui locus de desenvolvimento para a iniciação em Educação Interprofissional pela potencialidade em estimular o aprimoramento  de práticas colaborativas. O Coral é composto por discentes da graduação dos cursos de medicina, enfermagem, fisioterapia, terapia ocupacional, fonoaudiologia e profissionais de diversas áreas, além da saúde. Sendo um grupo de aprendizagem musical, desenvolvimento vocal, de integração e inclusão social, constituído por diferentes relações interpessoais e de ensino-aprendizagem, exige a aquisição de competências colaborativas, uma vez que cada grupo de voz deve aprender sobre o trabalho conjunto e sobre as especificidades de cada um. Considerando que o canto coral proporciona trabalho em equipe, integração, respeito à especificidade, favorece ao planejamento participativo, a tolerância, a negociação e  a  tomada de decisão, inserir a prática do canto coral, como um programa de iniciação a educação interprofissional, poderá consubstanciar o desenvolvimento de competências colaborativas, a ação de cada um levará aos resultados esperados por todos. Visando verificar se a participação no coral desenvolve habilidades e competências necessárias a prática colaborativa e a educação interprofissional será realizada entrevistas com os discentes, dos vários cursos da área da saúde que integram o coral, na perspectiva de encontrar congruências em relação ao trabalho em equipe e a colaboração entre eles, durante o desenvolvimento das atividades.
Gestão do Trabalho em Equipe nos Serviços Hospitalares
Authors: Lima Ana Clara Barreiros dos Santos , Dos Santos Isaane Lopes , Peduzzi Marina , Spinoza Pilar
Published: December 2020

Introdução: Trata-se de uma síntese de evidência de caráter exploratório que teve como objetivo identificar e analisar na literatura como é feita a gestão do trabalho em equipe nos serviços hospitalares. Método: Exploramos as bases (BVS, Pubmed, Web of Science e Cinahl) com operadores de busca (OR e AND) e os filtros texto completo, idioma (português, inglês e espanhol), sem limitação de data de publicação e humanos e, aplicados os critérios de inclusão: artigo com qualquer desenho de estudo; publicações que tratassem como tema central da gestão do trabalho em equipe nos serviços hospitalares. Resultados: Após leitura do título e resumo dos 399 artigos foram selecionados 25 artigos (BVS 04 artigos, Pubmed 11, Web of Science 03, Cinahl 07) para leitura na íntegra e análise, da qual resultaram apenas 03 artigos que respondiam ao objetivo proposto. Evidenciou-se um maior número de publicações nos últimos dois anos, em sua maioria a partir de 2015 com estudos realizados na atenção primária. Nos resultados identifica-se escassez de publicações nacionais relacionadas ao tema central do estudo no âmbito hospitalar, onde poucas organizações apoiam a prática interprofissional, uma vez que o trabalho em equipe é ainda desenvolvido de forma multiprofissional, com frágil colaboração, sem evidência de uma comunicação efetiva entre gestores e equipe, além da falta de clareza de papéis. As publicações mostram o reconhecimento de que a interdisciplinaridade e o trabalho em equipe melhoram o vínculo entre os profissionais e pacientes, contribuem para resultados positivos como: segurança, satisfação e qualidade no atendimento. Conclusão: Constatou-se a necessidade de novos estudos sobre gestão do trabalho em equipe que perpassem os aspectos burocráticos e retratem sobre as ações de gestão para o desenvolvimento do trabalho em equipe nos serviços hospitalares, contribuindo assim para o trabalho interprofissional colaborativo.
Trabalho interprofissional na Estratégia Saúde da Família – relato de experiência de uma proposta de formação continuada de trabalhadores
Authors: Neri Ana Paula , Aquiles Grace Jacqueline , Gasquez Adriana Sant’Ana , Fabri Clicie Arrias , De Oliveira Heloisa Amboni
Published: December 2020

Com a implantação da Estratégia Saúde da Família (ESF), tem-se discutido sobre o desafio de formar profissionais para uma atuação de caráter interprofissional e valorização das práticas colaborativas, em uma visão usuário centrada. A formação de profissionais de saúde e o desenvolvimento dos trabalhadores que atuam no Sistema Único de Saúde (SUS) são eixos fundamentais da Política Nacional de Educação Permanente em Saúde e devem acontecer de forma indissociada e organizada a partir das necessidades de saúde da população e do território (BRASIL, 2016). Este relato tem como objetivo descrever a atuação da preceptoria para uma equipe da ESF de uma Unidade Básica de Saúde de um município de médio porte do noroeste do Paraná. Metodologia: Na organização do processo de trabalho da equipe da ESF, preconizou-se as reuniões semanais com os trabalhadores, para um trabalho de formação em relação a tomada de decisões e planejamento de suas ações. Percebia-se nessas ocasiões uma disputa entre as categorias profissionais na escolha dos problemas a serem abordados prioritariamente pela equipe. A preceptoria da equipe, fundamentada nos conceitos de interprofissionalidade e colaboração ativa e aliada às metodologias ativas de ensino aprendizagem, estruturou o espaço de debates e pactuação  da equipe. Para auxiliá-los nas discussões e demandas cotidianas foi elaborado um instrumento, onde constam as solicitações individuais à equipe e suas contrareferências.  Para as demandas de caráter mais abrangente utiliza-se um método de planejamento estratégico situacional. Resultados e Conclusão: Nesses encontros as metodologias ativas proporcionaram um deslocamento dos trabalhadores de um papel passivo de receber e reproduzir conceitos para atividades que produziram um pensamento ativo e contribuíram para parte de uma mudança no local de trabalho. Nessa perspectiva o trabalho interprofissional mediado pelas metodologias ativas, foram ponto de partida para reflexões e reelaboração de novas práticas de cuidados.
Pengaruh kualitas layanan, kepuasan pelanggan dan keterikatan pelanggan terhadap loyalitas pelanggan grab di Surabaya
Authors: Bara Fadela , Prawitowati Tjahjani
Published: December 2020

Customer Loyalty indirectly help companies to promote products or services to the people closest to them. This is will be greatly help the company to get new customers. To increase Customer Loyalty, the company is expected to improve the quality of services provided. Quality is closely related to Customer Satisfaction and Customer Engagement, quality encourages customers to establish long-term bonds of mutual benefit in the company and Customer Engagement can increase Customer Loyalty because of the high level of Customer Engagement is the result of Customer Satisfaction of the product or service provided by the company.
EFFECT OF PHYSICAL EXERCISES WITH RESPIRATORY SIMULATORS ON CLINICAL AND FUNCTIONAL INDICATORS IN PATIENTS WITH BRONCHOPULMONARY AND CEREBROVASCULAR PATHOLOGY
Authors: Dyshko B , Mizin V , Ezhov V , Dudchenko L
Published: December 2020

Aim. The paper aims to evaluate the effectiveness of respiratory training as part of a comprehensive spa and medical rehabilitation. Materials and methods. Studies were performed in 90 patients with bronchial asthma and 60 patients with chronic cerebral ischemia. During physical training, New Breath breathing simulators were used. The effectiveness of medical rehabilitation was evaluated according to the severity of impaired body functions related to the corresponding domains of the International Classification of Functioning, Disability and Health. Results. Under rehabilitation, the condition of patients in both groups improved significantly, systemic rehabilitation effects in the form of improved indicators of the blood system and its oxygen transport functions, as well as increased reserves for handling stress and other psychological demands were notified. Conclusion. The study suggests the inclusion of physical exercises with the New Breath simulator in the comprehensive rehabilitation of patients with chronic cerebral ischemia and obstructive diseases of the respiratory system.
Trichoderma asal akar kopi dari Alor: Karakterisasi morfologi dan keefektifannya menghambat Colletotrichum Penyebab Penyakit Antraknosa secara in Vitro
Authors: Molebila Didiana Yanuarita , Rosmana Ade , Tresnaputra Untung Surapaty
Published: December 2020

Trichoderma of coffee roots from Alor: Morphological characteristic and in vitro efficacy to inhibit Colletotrichum, causing Anthracnose

Trichoderma is a fungus capable of intimate associations with plant root systems including on coffee plants. This aim of study is to determine the characteristics of Trichoderma  morphospecies from coffee roots of Alor origin, East Nusa Tenggara (NTT) and its ability to inhibit the growth of Colletotrichum causing anthracnose disease in-vitro. Root samples of healthy coffee plants were taken from the location of coffee plantations in Alor District, NTT. Isolation of Trichoderma fungi from coffee roots was done by incubating the sterilized coffee roots in a layer of moist filter paper in a Petri dish for seven days. Identification of Trichoderma by observing the characteristics of the colony on the medium of potato dextrose agar (PDA)  and microscopic media using microcultures (slide culture). Inhibition of Trichoderma fungi against Colletotrichum was tested by multiple culture methods on PDA media. The results of root incubation in humid conditions showed that there was four morphospecies of Trichoderma fungi, each of which had different characteristic specifications. In vitro antagonism in test on PDA medium, the first three morphospecies against Colletotrichum showed that each Trichoderma could inhibit 70.2%, 65.8%, and 63.3%, respectively, five days after inoculation. This data shows that Trichoderma isolated from coffee roots from Alor has the potential to suppress the growth of anthracnose pathogens.
Pengamatan dan Pemetaan Penyakit Busuk Pangkal Batang di Perkebunan Kelapa Sawit Menggunakan Unmanned Aerial Vehicle (UAV) dan Kamera Multispektral
Authors: Santoso Heri
Published: December 2020

Surveillance and Mapping of Basal Stem Rot Disease in Oil Palm Plantation Using Unmanned Aerial Vehicle (UAV) and Multispectral Camera

Basal stem rot (BSR) disease caused by Ganoderma boninensis is still a major disease in oil palm plantations both in Indonesia and Malaysia. In some countries, remote sensing approach has been used for monitoring BSR in oil palm plantation. However, the utilization of satellite imagery in remote sensing especially in vegetation study on the tropical region was often limited by cloud cover. A drone or unmanned aerial vehicle (UAV) utilization is the best way to deal with cloud cover in the tropic region. Machine learning of random forest (RF) and satellite imagery used in the BSR study produced good accuracy. This research was aimed to identify and monitor the BSR infection on individual oil palm trees using an UAV and multispectral camera and RF classification. The results showed that the data acquired from UAV was affected by cloud shadows. The RF classification of healthy and infected oil palm trees by BSR disease and the spreading map of BSR infection was affected by cloud shadows. The highest accuracy of healthy and infected oil palm by BSR was 79.49%. Reflectance calibrator, digital to reflectance conversion, and model implications to build spreading map of BSR infection need to be conducted both on the clear area and the cloud shadow-covered area. Moreover, the UAV-based data should be considering the cloud view on the coverage area.
RIGHT TO THE CITY AND RIGHT TO THE NON-CITY: NEO-EXTRACTIVISM AND SOCIAL MOVEMENTS IN SOUTHERN EUROPE
Authors: PANICO CARLA
Published: December 2020

This text aims to propose a reflection on the phenomenon of so-called touristification within the geographical area of Southern Europe concerning two points: how the processes of production of space that go under this name can be placed inside of the framework of the neo-extractive processes and how social movements against tourism may eventually resonate with the perspective of political ecology. The hypothesis is that this typology of accumulation processes responds to certain colonial rationality of capitalist exploitation within a specific area of the Global North – Southern Europe – starting from the global economic crisis of 2008, which I assume as a historical period characterized by specific forms of production of space (Lefebvre 1974) and specific social movements – the anti-tourism movements and the environmental struggles.
Lisa Källström, Pippi mellan världar: En bildretorisk studie
Authors: Bjorvand Agnes-Margrethe
Published: December 2020

Review/Recension
Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration inNpas2Mutant Mice
Authors: DePoy Lauren M. , Becker-Krail Darius D. , Zong Wei , Petersen Kaitlyn , Shah Neha M. , Brandon Jessica H. , Miguelino Alyssa M. , Tseng George C. , Logan Ryan W. , McClung Colleen A.
Published: December 2020

Substance use disorder (SUD) is associated with disruptions in circadian rhythms. The circadian transcription factor neuronal PAS domain protein 2 (NPAS2) is enriched in reward-related brain regions and regulates reward, but its role in SU is unclear. To examine the role of NPAS2 in drug taking, we measured intravenous cocaine self-administration (acquisition, dose–response, progressive ratio, extinction, cue-induced reinstatement) in wild-type (WT) andNpas2mutant mice at different times of day. In the light (inactive) phase, cocaine self-administration, reinforcement, motivation and extinction responding were increased in allNpas2mutants. Sex differences emerged during the dark (active) phase withNpas2mutation increasing self-administration, extinction responding, and reinstatement only in females as well as reinforcement and motivation in males and females. To determine whether circulating hormones are driving these sex differences, we ovariectomized WT andNpas2mutant females and confirmed that unlike sham controls, ovariectomized mutant mice showed no increase in self-administration. To identify whether striatal brain regions are activated inNpas2mutant females, we measured cocaine-induced ΔFosB expression. Relative to WT, ΔFosB expression was increased in D1+ neurons in the nucleus accumbens (NAc) core and dorsolateral (DLS) striatum inNpas2mutant females after dark phase self-administration. We also identified potential target genes that may underlie the behavioral responses to cocaine inNpas2mutant females. These results suggest NPAS2 regulates reward and activity in specific striatal regions in a sex and time of day (TOD)-specific manner. Striatal activation could be augmented by circulating sex hormones, leading to an increased effect ofNpas2mutation in females.

SIGNIFICANCE STATEMENTCircadian disruptions are a common symptom of substance use disorders (SUDs) and chronic exposure to drugs of abuse alters circadian rhythms, which may contribute to subsequent SU. Diurnal rhythms are commonly found in behavioral responses to drugs of abuse with drug sensitivity and motivation peaking during the dark (active) phase in nocturnal rodents. Emerging evidence links disrupted circadian genes to SU vulnerability and drug-induced alterations to these genes may augment drug-seeking. The circadian transcription factor neuronal PAS domain protein 2 (NPAS2) is enriched in reward-related brain regions and regulates reward, but its role in SU is unclear. To examine the role of NPAS2 in drug taking, we measured intravenous cocaine self-administration in wild-type (WT) andNpas2mutant mice at different times of day.
Estimates of net community production from multiple approaches surrounding the spring ice-edge bloom in Baffin Bay
Authors: Burgers Tonya M. , Tremblay Jean-Éric , Else Brent G. T. , Papakyriakou Tim N.
Published: December 2020

Measurements of net community production (NCP) provide an upper constraint on the strength of the oceanic biological pump, the dominant mechanism for removing CO2 from the ocean surface and sequestering it at depth. In this investigation, our objectives were to describe the spatial and temporal variability of NCP associated with the spring ice-edge bloom in Baffin Bay and to identify the key environmental drivers controlling its variability. Using data collected between June 9 and July 10, 2016, we estimated NCP based on (1) underway measurements of surface water oxygen to argon ratios (O2:Ar), (2) underway measurements of the partial pressure of CO2, and (3) seasonal nitrate drawdown from discrete samples. These multiple approaches displayed high NCP (up to 5.7 mol C m–2) in eastern Baffin Bay, associated with modified Atlantic waters, and low NCP (<1 mol C m–2) in the presence of Arctic outflow waters in western Baffin Bay. Arctic outflow waters were characterized by low surface salinities and nitrate concentrations, suggesting that high freshwater content may have limited the nutrient availability of these waters. Different integration depths and timescales associated with each NCP approach were exploited to understand the temporal progression and succession of the bloom, revealing that the bloom was initiated under ice up to 15 days prior to ice retreat and that a large portion of NCP in eastern Baffin Bay (potentially up to 70%) was driven by primary production occurring below the surface-mixed layer.
Successful Endovascular Repair of a Kommerell’s Diverticulum and a Right-Sided Aortic Arch
Authors: Hayakawa Masato , Nagano Takaaki , Nishijima Isao , Shinzato Kento , Ikemura Ryo , Miyagi Kazufumi , Iha Kiyoshi , Senaha Shigenobu , Shimoji Mitsuyoshi , Akasaki Mitsuru
Published: December 2020

Background: A 57-year-old woman was diagnosed with Kommerell’s diverticulum in the setting of a right aortic arch on computed tomography.
Case report: Although asymptomatic, the maximum diameter of the aneurysm was 55 mm; thus, she underwent surgery to prevent rupture of the aneurysm. A bypass was constructed from the left common carotid artery to the left subclavian artery. A stent-graft was deployed from the distal right subclavian artery, and coil embolization of the diverticulum was performed via the left subclavian artery. She was discharged after 12 days of surgery. The postoperative four-month follow up showed a smaller aneurysm.
Conclusion: Thoracic endovascular aortic repair is feasible and effective for Kommerell’s diverticulum.
Estado Del Arte Scopus Sostenibilidad Del Recurso Hídrico
Authors: Camilo Alejandro Corchuelo Rodriguez , Cristian Alexander Vega Mosquera , Luz Marina Paez
Published: December 2020

Este informe muestra el estado actual y las tendencias de las publicaciones Scopus relacionadas con el tema “Sostenibilidad del recurso hídrico”. Se presenta las cifras de las publicaciones, citas, colaboraciones y tendencias entre otros. Este es un insumo para la comunidad académica USTA cuyo objetivo es identificar tendencias mundiales en las publicaciones para articular líneas y grupos de investigación. Abstract
Estado del arte scopus Poblaciones vulnerables y territorio
Authors: Camilo Alejandro Corchuelo Rodriguez , Cristian Alexander Vega Mosquera , Luz Marina Paez , Karoll Piza Amado
Published: December 2020

Este informe muestra el estado actual y las tendencias de las publicaciones Scopus relacionadas con el tema “Poblaciones vulnerables y territorio”. Se presenta las cifras de las publicaciones, citas, colaboraciones y tendencias entre otros. Este es un insumo para la comunidad académica USTA cuyo objetivo es identificar tendencias mundiales en las publicaciones para articular líneas y grupos de investigación
Universidad y gobernanza: la política de los saberes
Authors: Luis Fernando Bravo León
Published: December 2020

Estos son algunos apuntes sobre la universidad y la gobernanza. Para abordar estas reflexiones la hemos amparado en el concepto de política de los saberes. Entendemos como política de los saberes al papel central que cumple la universidad en la organización y gestión de las sociedades y los estados nacionales desde el origen mismo de la Universidad hasta el desafío planetario de la preservación de la vida. Por ello presentamos sus notas características, misionales y de la cultura académica, para el caso de la Universidad Santo Tomás, en la perspectiva de la definición de su naturaleza como universidad de estudios generales: Universidad de docencia que desarrolla investigación con orientación social.
Plan estratégico de la red académica y de investigación. Red de Paz Maestros Colombia
Authors: Jhonny Alberto Botero Guzmán , Claudia Patricia Tarquino Acosta , Jhon Fernando Hurtado Hurtado , Daniel Alejandro Contreras Castro
Published: December 2020

La Red Paz Maestros se propone como un escenario académico de articulación entre estudiantes, docentes y personas inquietas por el análisis de los procesos educativos en los cuales, todos nos vemos implicados a través de la práctica pedagógica por las dinámicas entre los procesos de la enseñanza y aprendizaje. El trabajo de investigación asume como referente LA ESCUELA y los procesos de enseñanza y aprendizaje que se implementan en los diferentes contextos según el lugar de trabajo de los estudiantes, docentes o investigadores vinculados a la Red Paz Maestros. Desde allí, reconocer el contexto, determinar necesidades y la posibilidad de establecer nuevos paradigmas que aporten a la educación respondiendo a las necesidades y búsquedas que cada día se generan frente a la labor educativa.
Nuevos análisis traceológicos, arqueométricos y petrológicos de material metálico y lítico recuperado en un lugar sagrado de la cultura de Las Motillas: Castillejo del Bonete (Terrinches, Ciudad Real)
Authors: Benítez de Lugo Enrich Luis , Baeza Chico Eleuterio , Delvene Graciela , Gutiérrez Sáez Carmen , Márquez Mora Belén , Menchén Herreros Gabriel , Muñoz Moro Pedro , Odriozola Lloret Carlos
Published: December 2020

Castillejo del Bonete es fue un lugar sagrado utilizado durante el III y II milenios cal BC al sur de La Mancha. Se usó como monumento de culto y funerario; dispone de corredores y construcciones orientados a los solsticios. El trabajo aquí presentado aporta los recientes resultados del estudio analítico de diferentes clases de materiales arqueológicos selectos depositados en este lugar: estelas funerarias, cuentas, útiles metálicos y líticos. En cuanto a la piedra tallada, se han llevado a cabo análisis de uso en diferentes piezas. Respecto a la piedra pulida, se ha desarrollado un análisis con microscopio electrónico de barrido de una cuenta de caolinita roja, así como análisis traceológicos de brazales de arquero. Análisis paleontológicos y petrológicos se han realizado sobre una estela funeraria encontrada en el interior de la cueva mortuoria. Esta serie de analíticas realizadas sobre materiales selectos se añade a las hasta ahora existentes, ya publicadas. En el estado actual de conocimientos es posible afirmar que la cultura material enterrada en Castillejo del Bonete en su mayor parte no difiere de la utilizada durante la vida cotidiana, pero fue amortizada para ser puesta al servicio de un ritual que giró en torno a los ancestros y un culto solar. Esa tradición prolongó durante las Edades del Cobre y el Bronce, siendo un reflejo de los inicios de la jerarquización social y de la monumentalización del territorio al sur de la Meseta.
La ordenación territorial romana del alto Guadiana y el Corpus Inscriptionum Latinarum (CIL)
Authors: Manuel Abascal Juan
Published: December 2020

El río Guadiana (Anas) nace cerca de Laminium (Alhambra, Ciudad Real) y en su tramo superior, hasta el embalse del Cijara, atraviesa de este a oeste La Mancha por los territorios de la propia Laminium y de Oretum. En esta región tan grande sólo conocemos estas dos ciudades de época romana. El número de testimonios epigráficos no es muy elevado y están concentrados especialmente en las comarcas próximas a los ríos Guadiana y Jabalón. En el texto se muestra un modelo de ordenación territorial que ha sido aplicado para la elaboración del fascículo correspondiente de CIL II.
La cerámica pintada tardoantigua, de tradición indígena, documentada en la villa romana de El Saucedo (Talavera la Nueva, Toledo)
Authors: Blanco García Juan Francisco , Castelo Ruano Raquel , López Pérez Ana María , Zamora Merchán Mar , Bustamante-Álvarez Macarena , Donate Inmaculada , Blanco Manuel , Cabello Cristina , Cruz Medina María , Pardo Ana Isabel
Published: December 2020

Presentamos en este artículo el estudio tecno-tipológico de las cerámicas pintadas romanas de tradición indígena de época tardoantigua aparecidas en las campañas de excavación realizadas en la villa de El Saucedo (Talavera la Nueva, Toledo). A través de su análisis y caracterización arqueométrica hemos podido determinar la existencia de dos grupos diferenciables. El primero integrado por producciones que debieron de realizarse en algún taller de la submeseta sur y el segundo por aquellas otras que presentan entre sus desgrasantes abundante mica de color dorado, además de otros componentes. Dichas cerámicas quizá fueron elaboradas en un alfar ubicado en la vecina civitas de Caesarobriga (Talavera de la Reina). El análisis arqueométrico se ha realizado mediante Microscopía Óptica (MO), microanálisis SEM-EDX y análisis DRX.
La fase Almohade de La Alcazaba de Badajoz
Authors: Cortés Rodrigo , Valdés Fernando
Published: December 2020

La última de las ampliaciones islámicas de la Alcazaba de Badajoz se llevó a cabo durante el período almohade. Sin embargo, las evidencias arqueológicas, resultado de los trabajos llevados a cabo allí entre 2010 y 2012, han aportado informaciones que permiten establecer tres fases, dentro de aquel período.