bluuebunny/crossref_metadata_2025 huggingface dataset:
BIOMARKERS OF CARDIOVASCULAR COMPLICATIONS ASSOCIATED WITH COVID-19 DISEASE
Authors: Kushnarova Nataliia , Zinych Olesia , Kovalchuk Alla , Prybyla Olha , Shyshkan-Shyshova Kateryna
Published: January 2024

The coronavirus disease (COVID-19), which caused a global pandemic in the world, is now becoming an endemic, seasonal disease. Therefore, the search for new biomarkers to predict the course of the disease and its outcomes remains extremely important. It has been found that COVID-19 affects not only the respiratory system but also other organs and systems of the body. In particular, the target of the SARS-CoV-2 virus is the cardiovascular system. Because the severity of COVID-19 disease is highly variable, laboratory biomarkers can provide important prognostic information already at the emergency stage, especially in patients with atypical manifestations. It has been demonstrated that viral infections, and in particular COVID-19, can cause changes in the host's lipid profile. Changes in the processes of intracellular cholesterol biosynthesis and its transport in the bloodstream of patients with COVID-19 have been reported. Thus, in patients suffering from COVID-19, significantly reduced levels of total іукгь cholesterol (C), HDL, and LDL cholesterol, and an increased ratio of triglycerides/C have been recorded. Patients with COVID-19 are characterized by an increased content of residual (remnant) cholesterol, which is defined as cholesterol present in residual lipoproteins rich in triglycerides and, as shown by the results of genetic, observational, and clinical studies, is associated with the development of atherosclerosis and overall mortality. Several peptide cardiac biomarkers have become other predictors of cardiovascular prognosis in patients with COVID-19: highly sensitive cardiac troponin – successfully used in clinical practice as a marker of myocyte damage for diagnosis and prognostic assessment of acute coronary syndrome; N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker of myocardial stretch; peptide ST2 – a marker of remodeling of myocardial extracellular matrix, which prevents fibrosis, cardiac hypertrophy and apoptosis; copeptin is a biomarker of neurohumoral activation. The review provides a concise analysis of currently known cardiac biomarkers in COVID-19 and their prognostic significance.
NATIONAL ORIENTATION OF THE TEXTBOOK FROM PHYSICS AS AN IMPORTANT FACTOR PATRIOTIC EDUCATION
Authors:   Український державний університет імені Михайла Драгоманова, BLAGODARENKO L. , VASILENKO S. ,   Український державний університет імені Михайла Драгоманова
Published: January 2024

У статті наголошено, що проблема виховання патріотичної особистості нині набуває особливого змісту, оскільки в нашій країні в умовах військового часу відбувається консолідація суспільства. Зауважено, що більшість учителів фізики не приділяють уваги цьому вкрай важливому питанню з різних причин, серед яких основними є такі, як відсутність у молоді мотивації до вивчення фізики, обмеженість навчального часу, слабка готовність учнів до засвоєння знань, нерозуміння ними ролі науки в розвитку техніки та всієї сучасної цивілізації, а також ролі фізики особисто для себе. Констатовано, що виховання патріотизму та почуття національної гідності можливо лише на спільній ідеології, адже вона забезпечує утвердження у свідомості певних цінностей і переконань, а головне – поваги до здобутків культури і науки держави. Тому необхідно шукати усі можливі підходи до ефективного формування національної самосвідомості, зокрема, знайомити молодь із науковою спадщиною українських науковців, а також сучасними досягненнями науки в нашій країні, які забезпечують суспільний, економічний і соціальний розвиток. Відзначено, що освітній процес з фізики в закладах загальної середньої освіти має значний потенціал щодо формування в молоді почуття національної гідності і виховання патріотизму. На прикладі змістовного наповнення підручників з фізики авторів М. Шута, М. Мартинюка, Л. Благодаренко показано, як можна максимально реалізувати цей потенціал. Зазначено, що сучасні вимоги до створення підручника значно обмежують обсяг навчального матеріалу, але авторам названих підручників вдається дотримуватися визначеної ними концепції, яка передбачає формування в учнів почуття національної гідності та виховання патріотизму з використанням навчального матеріалу курсу фізики. Показано, як можна з мінімальними витратами обсягу підручника вирішити проблеми обмеженості місця для інформації, що здатна формувати в учнів почуття національної гідності та виховання патріотизму. Ключові слова: освітній процес з фізики, національна спрямованість підручника фізики, патріотичне виховання.
ВИКОРИСТАННЯ МЕТОДУ ПРОЄКТІВ ДЛЯ РОЗВИТКУ SOFT SKILLS НАВИЧОК У МАЙБУТНІХ УЧИТЕЛІВ
Authors:   Бердянський державний педагогічний університет, KONDRATIEVA O.
Published: January 2024

Формування «soft skills» для студентів – об’єктивна вимога сучасного європейського суспільства, тому процес підготовки високоосвіченого педагогічного спеціаліста актуалізує проблему організації процесу навчання, який сприяє самореалізації особистості студента шляхом розвитку його інтелектуальних і організаційних можливостей, вольових якостей та творчих здібностей. У статті проаналізовано застосування методу проєктів у процесі формування навичок soft skills у студентів. Акцентовано, що формування «м’яких навичок» у наш час є важливим складником підготовки майбутніх учителів. Теоретично обґрунтовано доцільність застосування методу проєктів для формування умінь приймати рішення в ситуаціях нестачі часу; лідерських якостей, здатності до візуалізації інформації; уміння публічно виступати; навичок тайм-менеджменту, організації міжособистісного спілкування. Особливу увагу звернено на структурні складові поняття soft skills. Встановлено, що важливими є креативність, професійна англомовна комунікація, критичне мислення, самоорганізація. З’ясовано важливу роль застосування методу проєктів для формування вміння адаптуватися до швидкозмінних вимог сучасного суспільно-економічного розвитку, самостійно окреслювати особисті та професійні цілі, демонструвати уміння дотримуватися дедлайнів, розвивати комунікативні навички та уміння співпраці в колективі, виявляти власний лідерський потенціал. Акцентовано увагу на проєктної діяльності, що значно покращує інтелект майбутніх учителів; здатність до емпатії; активізує спроможність працювати в команді; вміння бути переконливим і впливовим під час виступів, дискусій і переговорів, вдумливо шукаючи рішення, що задовольнить усі сторони; здатність досягати порозуміння з людьми. Сутність вищесказаного зводиться до того, що застосування методу проєктів сприяє формуванню навичок soft skill у студентів та підвищує їхню конкурентоздатність у сучасному освітньому просторі. Перспективою подальшої розвідки у даному напрямку визначено практичний аспект застосування методу проєктів для розвитку soft skills у студентів. Ключові слова: «soft skills», метод проєктів, професійна педагогічна підготовка майбутніх учителів, освітнє середовище.
DEVELOPMENT OF THE PROJECT CULTURE OF FUTURE TEACHERS IN THE EDUCATIONAL ENVIRONMENT OF A HIGHER EDUCATION INSTITUTION
Authors:   Державний заклад «Південноукраїнський національний педагогічний університет імені К. Д. Ушинського», LYSTOPAD O. , MARDAROVA I. ,   Державний заклад «Південноукраїнський національний педагогічний університет імені К. Д. Ушинського», HUDANYCH N. ,   Державний заклад «Південноукраїнський національний педагогічний університет імені К. Д. Ушинського»
Published: January 2024

Метою статті є аналіз особливостей розвитку проєктної культури майбутніх педагогів в освітньому середовищі закладу вищої освіти. Проведене дослідження дає підставу розглядати педагогічне проєктування як особливий вид складної багатоступеневої діяльності, що виявляється у володінні педагогом проєктними знаннями, уміннями та здібностями їх застосування у розв’язанні професійних завдань. Проєктна культура майбутніх педагогів дошкільної освіти це інтегративна характеристика особистості, що відображає здатність і готовність майбутнього педагога дошкільної освіти до проєктування індивідуальних траєкторій розвитку дітей раннього і дошкільного віку, проєктування змісту дошкільної освіти, побудови маршрутів власного розвитку та самовдосконалення проєктних знань, умінь навичок і досвіду проєктної діяльності. Проєктна культура педагога дошкільної освіти включає: розуміння особливостей дошкільного віку (глибоке розуміння особливостей розвитку дитини дошкільного віку, її потреб і можливостей, знати, які методи і підходи до організації освітнього процесу є найбільш ефективними у цьому віковому періоді); формування творчого, ігрового середовища закладу дошкільної освіти (створювати цікаве та стимулююче ігрове середовище для дітей дошкільного віку, сприяти їх творчому розвитку та самовираженню через гру); розвиток творчого мислення (стимулювати творчість дітей, сприяти розвитку їх творчого мислення та уяви, надавати можливості для самостійного творчого виявлення дітей, підтримувати їх ідеї та ініціативи); використання проєктних методів у роботі з дітьми (вміти організовувати та проводити проєктну роботу з дітьми дошкільного віку, використовувати різні методи та форми роботи, такі як групова робота, дослідницька діяльність, майстер-класи тощо); сприяння соціальному розвитку (створювати умови для соціального розвитку дітей, сприяти формуванню навичок співпраці, комунікації та взаємодії з оточуючим світом, організовувати спільні проєкти та заходи, які сприяють соціалізації дітей). Встановлено, що структура проєктної культури майбутніх педагогів дошкільної освіти представлена в сукупності таких трьох компонентів: мотиваційно-особистісний компонент, когнітивно-процесуальний компонент, діяльнісно-управлінський компонент. Визначено рівні розвитку проєктної культури майбутніх педагогів дошкільної освіти: неприпустимий, допустимий, оптимальний. Представлено результати експериментального дослідження розвитку проєктної культури майбутніх педагогів дошкільної освіти. Ключові слова: проєкт, розвиток, проєктна діяльність, педагог, дошкільник, розвиток проєктних умінь, проєктна культура.
Hardiness dan Resiliensi Terhadap Intensi Wirausaha Pada Mahasiswa
Authors: Sasmita Nursakinah Oktaviana , Afriyenti Lenny Utama
Published: January 2024

Meningkatnya peminatan masyarakat dalam berwirausaha dirasakan sejumlah pihak.  Menurut tinjauan dari Walter (koinwork), adanya peningkatan sejumlah 3, 10% dari total penduduk di Indonesia, namun menurut tim redaksi CNBC (2022) Jumlah Entrepreneur RI Cuma 3,4% dari Populasi, masih kurang karena belum memenuhi batas 14% dari total penduduknya. Dalam laporan Setya (2022), ada 17 kampus yang menyelenggarakan Wirausaha Merdeka yang bertujuan untuk mencari calon pemimpin dan innovator bisnis yang dapat memperkecil angka pengangguran bahkan memperluas jumlah lapangan kerja di Indonesia. Penelitian ini bertujuan ingin mengetahui kepribadian hardiness dan resiliensi apakah mempengaruhi keinginan untuk meningkatkan intensitas berwirausaha. Sampel berjumlah 118 orang.  Penelitian ini menghasilkan korelasi yang cukup kuat dari Hardiness terhadap Kesehatan mental, maupun Resiliensi terhadap Kesehatan Mental.

Kata Kunci: Kata kunci: Intensi Wirausaha, Hardiness, Resiliensi,  Mahasiswa,
Optimalisasi Produksi Kuliner Berbahan Dasar Mangrove Dalam Meningkatkan Daya Saing Usaha di Kabupaten Muara Gembon
Authors: Satria Budi , Perdhana Timorora Sandha
Published: January 2024

This research aims to; find out whether there is a significant positive effect between raw material inventory control on the production process, find out whether there is a significant positive effect between production process planning on the production process, find out whether there is a significant positive effect between raw material inventory control on business competitiveness, find out whether there is an influence significant positive relationship between production process planning and business competitiveness and to determine whether there is a significant positive effect between the production process and business competitiveness. The research method used in this study was a survey method using descriptive research methods with a quantitative approach involving 32 business actors in the Mangrove-Based culinary field in Muara Gembong Regency. The results of the study show that Raw Material Inventory Control has a significant effect on Business Competitiveness. In direct and indirect testing it is known that Raw Material Inventory Control has a direct and significant effect on the Competitiveness of Mangrove-Based Culinary Businesses in Muara Gembong Regency. While the Production Planning Process has a significant effect on Business Competitiveness. This means that the better the Production Planning Process will be able to improve the competitive positioning of Mangrove-Based culinary businesses in Muara Gembong Regency
Rosai-Dorfman disease of the cauda equina: illustrative case
Authors: Mangham William , Lesha Emal , Nico Elsa , Yagmurlu Kaan , Golembeski Christopher P , Portnoy David C , Weaver Jason
Published: January 2024

BACKGROUND

Rosai-Dorfman disease (RDD) is a rare, nonmalignant histiocytosis. It typically occurs in lymph nodes, skin, and soft tissues, but numerous reports of central nervous system involvement exist in the literature. The peripheral nervous system has rarely been involved. In this study, the authors present a case of RDD isolated to the cauda equina. The presentation, management, surgical technique, and adjunctive treatment strategy are described.

OBSERVATIONS

A 31-year-old female presented with 6 months of progressive left lower-extremity numbness involving the lateral aspect of the foot and weakness of the left toes. Magnetic resonance imaging of the lumbar spine demonstrated a homogeneously enhancing intradural lesion involving the cauda equina at the L2–3 levels. Histopathology after resection revealed a histiocytic infiltrate, positive for CD68 and S100, and emperipolesis consistent with RDD. No adjuvant therapy was administered, and the patient had full remission at the 1-year follow-up. Only five other cases of intradural RDD lesions of the cauda equina have been reported in the literature.

LESSONS

RDD of the cauda equina is an especially rare and challenging diagnosis that can mimic other dura-based lesions, such as meningiomas. A definitive diagnosis of RDD relies on pathognomonic histopathological and immunohistochemical findings.
A large cirsoid aneurysm of the scalp with multiple arterial supply: illustrative case
Authors: Pahari Soumya , Bhandari Paawan Bahadur , Bhattarai Bibek , Baniya Purushottam , Yadav Stuti , Subedi Prarthana , Mandal Sarbind
Published: January 2024

BACKGROUND

Cirsoid aneurysm of the scalp is a rare arteriovenous fistula having a traumatic, congenital, iatrogenic, or idiopathic etiology. Its presentation can range from a small swelling to a large pulsatile mass with tinnitus, headache, and scalp necrosis.

OBSERVATIONS

A 67-year-old female presented with a gradually increasing swelling on her forehead and head since childhood and no history of trauma. Examination revealed 12 × 5 cm tortuous midline swelling. Computed tomography angiography revealed a mass of tortuous vessels in the right frontoparietal region of the scalp with no bony defect or intracranial extension. Contrast-enhanced computed tomography of the head showed no intracranial pathology. The diagnosis of cirsoid aneurysm was made, and surgery was planned.

A bicoronal incision was made. The feeding arteries were dissected and ligated. The nidus was carefully separated, cauterized, and excised in toto. Inadvertently, a buttonhole in the skin was created while dissecting the nidus, which was sutured. The patient developed a small area of scalp necrosis on the 10th postoperative day, which was debrided and sutured. At the 6-month follow-up, no signs of recurrence were present.

LESSONS

A large cirsoid aneurysm of the scalp with multiple arterial supplies can be treated successfully with surgery. Meticulous dissection and hemostasis are warranted to avoid perioperative complications.
Surgical management of pediatric spinal aneurysmal bone cysts: patient series
Authors: Flyer Benjamin E , Vanstrum Erik B , Chapman Nicholas , Ha Joseph H , Al-Husseini Jacob K , Chu Jason K , McComb J. Gordon , Durham Susan R , Krieger Mark D , Chiarelli Peter A
Published: January 2024

BACKGROUND

Aneurysmal bone cysts (ABCs) are rare, highly vascular osteolytic bone lesions that predominantly affect pediatric populations. This report evaluates the clinicopathological data of pediatric patients with spinal ABCs. The medical records for all patients at Children’s Hospital Los Angeles with biopsy-proven ABCs of the spine between 1998 and 2018 were evaluated.

OBSERVATIONS

Seventeen patients, 6 males and 11 females, were identified. The mean age at surgery was 10.4 years (range, 3.5–20 years). The most common presenting complaint was pain at the lesion site 16/17 (94%), followed by lower-extremity weakness 8/17 (47%). Resection and intralesional curettage were performed in all patients. Three (18%) of 17 patients underwent selective arterial embolization prior to resection. Spinal stability was compromised in 15 of 17 patients (88%), requiring instrumented fusion. Five (29%) of the 17 patients received additional therapy including radiation, calcitonin-methylprednisolone, or phenol. Four (23.5%) of 17 patients experienced a recurrence, and the mean time to recurrence was 15 months. The postoperative follow-up ranged from 6 to 108 months (median, 28 months). Reoperation occurred after an average of 35 months. At the recent follow-up, patients were free of disease.

LESSONS

Gross-total resection by intralesional curettage with case-dependent instrumented spinal fusion for instability remains an effective strategy for managing pediatric spinal ABCs. Long-term follow-up is necessary to detect tumor recurrence.
Cerebral arterial vasospasm complicating supratentorial meningioma resection: illustrative cases
Authors: Pickles Andrew C , Tsiang John T , Pecoraro Alexandria A , Pecoraro Nathan C , Jani Ronak H , Bond Brandon J , Germanwala Anand V , Serrone Joseph C , Prabhu Vikram C
Published: January 2024

BACKGROUND

Cerebral arterial vasospasm is a rare complication after supratentorial meningioma resection. The pathophysiology of this condition may be similar to vasospasm after aneurysmal subarachnoid hemorrhage, and treatment options may be similar.

OBSERVATIONS

The authors present two cases of cerebral vasospasm after supratentorial meningioma resection and perform a systematic literature review of similar cases.

LESSONS

Cerebral arterial vasospasm after supratentorial meningioma resection may be associated with significant morbidity due to cerebral ischemia if not addressed in a timely manner. Treatment paradigms may be adopted from the management of arterial vasospasm associated with subarachnoid hemorrhage.
Effects of three-week intake of Matcha green tea powder on heart rate variability metrics
Authors: Willems Mark Elisabeth Theodorus , Foster Cameron Thomas
Published: January 2024

Introduction: Compared to other green teas, higher intake of multiple phytochemicals is achieved with Matcha green tea consumption. Green tea consumption is known to have metabolic effects but is also consumed for supposed calming effects. The aim of the present study was to examine the effects of encapsulated Matcha green tea on heart rate variability metrics during supine rest, as well as on physiological and metabolic responses during both supine rest and moderate-intensity exercise. Methods: Healthy females (n=8, age: 22±3 yrs, body mass: 68±11 kg, height: 162±5 cm) volunteered. The study employed a placebo-controlled, randomised cross-over design. Time-domain heart rate variability metrics during supine rest (n=5) and physiological and metabolic responses using indirect calorimetry techniques during supine rest and 60-min of moderate-intensity (~ 4-METs) treadmill walking (speed: 4.4±0.5 km·h-1) were measured following 3 weeks of 3 g·day-1 of Matcha green tea or placebo. Results: During supine rest with Matcha green tea, all participants had lower heart rates by 13±7% (P=0.01, d= -1.45), higher mean beat-to-beat RR intervals by 16±9% (P=0.03, d=1.25), higher SDNN by 44±32% (P=0.01, d=0.76) and higher pNN50 by 139±139% (P<0.01, d=1.28). Matcha green tea had no effects on the physiological and metabolic responses during supine rest and moderate-intensity treadmill walking (e.g. respiratory exchange ratio, placebo: 0.78±0.04; Matcha: 0.78±0.03, P=0.87). Fat oxidation during supine rest was correlated (r=0.75, P<0.01) with the moderate-intensity walking induced fat oxidation. Conclusions: In young adult healthy females, Matcha green tea beneficially effects heart rate variability metrics during supine rest indicating an alteration in parasympathetic nervous activity and therefore suggestive of a relaxing effect. Matcha green tea did not change the metabolic responses during supine rest and exercise possibly due to the low respiratory exchange ratio in the female cohort. Future work should address the effectiveness of Matcha green tea during conditions of psychological stress.Keywords: Matcha green tea, heart rate variability, rest, walking, substrate oxidation
Transcriptomic Profiling Reveals Neuroinflammation in the Corpus Callosum of a Transgenic Mouse Model of Alzheimer’s Disease
Authors: Takase Hajime , Hamanaka Gen , Hoshino Tomonori , Ohtomo Ryo , Guo Shuzhen , Mandeville Emiri T. , Lo Eng H. , Arai Ken
Published: January 2024

Background: Alzheimer’s disease (AD) is a widespread neurodegenerative disorder characterized by progressive cognitive decline, affecting a significant portion of the aging population. While the cerebral cortex and hippocampus have been the primary focus of AD research, accumulating evidence suggests that white matter lesions in the brain, particularly in the corpus callosum, play an important role in the pathogenesis of the disease. Objective: This study aims to investigate the gene expression changes in the corpus callosum of 5xFAD transgenic mice, a widely used AD mouse model. Methods: We conducted behavioral tests for spatial learning and memory in 5xFAD transgenic mice and performed RNA sequencing analyses on the corpus callosum to examine transcriptomic changes. Results: Our results show cognitive decline and demyelination in the corpus callosum of 5xFAD transgenic mice. Transcriptomic analysis reveals a predominance of upregulated genes in AD mice, particularly those associated with immune cells, including microglia. Conversely, downregulation of genes related to chaperone function and clock genes such as Per1, Per2, and Cry1 is also observed. Conclusions: This study suggests that activation of neuroinflammation, disruption of chaperone function, and circadian dysfunction are involved in the pathogenesis of white matter lesions in AD. The findings provide insights into potential therapeutic targets and highlight the importance of addressing white matter pathology and circadian dysfunction in AD treatment strategies.
Sensitivity analysis for the eddy current testing of carbon fiber reinforced plastic materials
Authors: Pintér Bálint , Bingler Arnold , Bilicz Sándor , Pávó József
Published: January 2024

In this work, a parametric study is carried out on carbon fiber-reinforced plastic (CFRP) materials to investigate how the spatially varying fiber distribution influences the measured signal in an eddy current testing (ECT) configuration. The measurement setup was modeled using finite element method, while the fiber distribution is taken into account by an inhomogeneous anisotropic conductivity tensor. The study revealed a trade-off relation between the size of the ECT coil and the maximal dynamic range of the ECT signal, which contributes to the understanding of the connection between the fiber arrangement and the ECT signal and provides an opportunity for optimal ECT coil design.
Multiple psychiatric diagnoses and return-to-work following posttraumatic stress injury rehabilitation
Authors: Krebs Brandon K. , Rachor Geoffrey S. , Yamamoto Shelby S. , Dick Bruce D. , Brown Cary A. , Asmundson Gordon J.G. , Straube Sebastian , Els Charl , Jackson Tanya D. , Brémault-Phillips Suzette , Voaklander Don , Stastny Jarett , Berry Theodore , Gross Douglas P.
Published: January 2024

BACKGROUND: Posttraumatic stress injury (PTSI) is a term used to describe a range of psychiatric difficulties which arise following exposure to a psychologically traumatic event. The impact of being diagnosed with multiple psychiatric conditions on the return-to-work (RTW) outcomes of individuals with PTSI has not been adequately researched. OBJECTIVE: The current study examined whether the presence of two or more psychiatric conditions occurring simultaneously is predictive of RTW outcomes in workers with PTSI. METHOD: A population-based cohort design was conducted using archival data from injured workers admitted to a PTSI rehabilitation program. Differences in RTW outcomes and demographic, administrative, and clinical variables were compared between individuals with single and multiple psychiatric diagnoses. A range of variables were entered into a multivariable logistic regression model predicting RTW. RESULTS: The final logistic regression model indicated workers had higher odds of RTW if they had a single psychiatric diagnosis (Adjusted Odds Ratio (AOR) 2.20), non-elevated scores on a measure of traumatic stress (AOR 1.85), and reported higher self-perceived readiness to RTW (AOR 1.24). CONCLUSION: Being diagnosed with multiple psychiatric conditions appears to be associated with more negative RTW outcomes following PTSI rehabilitation.
Theoretical and methodological approach to information support for grain production management
Authors: Arinichev Igor' Vladimirovich , Sidorov Viktor
Published: January 2024

Abstract. The purpose of the research is to determine the role of participants involved in data preparation under controlled and uncontrolled conditions for the development of intelligent systems for phytosanitary monitoring diagnostics, as well as to propose an architecture for their interaction at different levels of grain production The methodological basis of the study was the process and system approaches. The scientific novelty lies in substantiating the rational interrelation of participants in the process of data collection and preparation under different conditions. Results. The correlation between the main monitoring tasks and machine learning models is presented. An architecture for the interaction of data preparation agents at the individual, regional, and national levels of grain production has been developed. The advantages and disadvantages of implementing the process at each level are listed. The creation of a unified national database is recommended, where information from regional repositories is consolidated to ensure effective monitoring of grain production and make scientifically grounded decisions regarding grain fields management. It is shown that the existence of a central database will allow for scaling of intelligent diagnostic systems and tracking phytosanitary risks in different parts of the country. A number of conceptual elements of the information support methodology for grain production management are proposed, including data collection methods, confidentiality regulations, accessibility standards, data format, quality, and security. The filling and continuous updating of the national information database require significant efforts from specialists and serve as an important element of effective monitoring and decision-making in grain production at the national level. The need for interaction and communication between specialists from different fields is emphasized, as well as the importance of having an information infrastructure to ensure reliability, scalability, security, and accessibility of data.
The model of modernization of conceptual approaches of state regulation of the agro-food market of the region
Authors: Kuznecov Vladimir Vasil'evich , Holodova Marina
Published: January 2024

Abstract. The purpose of the study is to develop a model for the modernization of conceptual approaches to state regulation of the agro-food market of the region, which includes tools and mechanisms that eliminate imbalances in its development. The existing unilateral mechanism of state support for the agricultural sector in the face of agricultural producers does not ensure the maintenance of the total supply of food at the level of consumer demand, which, on the one hand, leads to a crisis of overproduction of certain types of food, on the other hand, does not allow to increase their economic accessibility. Methods. The instrumental and methodological apparatus of the study consisted of methods of comparative, structural-target, scenario analysis, expert assessments, cognitive modeling and others. The processing of analytical material, which ensures the reliability of calculations, was carried out using the IGLA decision support system. The scientific novelty lies in the substantiation of additional tools and mechanisms aimed at stimulating solvent demand, among which the development and implementation of a regional program of domestic food aid and a mechanism for stimulating solvent demand in the context of the regional State Program “Development of agriculture and regulation of agricultural products, raw materials and food markets” are proposed. Results. It is argued that the variety of factors affecting the functioning of the agri-food market, the high level of dynamism, multi-aspect and uncertainty of the processes taking place in it, the complexity of obtaining relevant information necessary to predict its development, allow us to attribute the agri-food market to complex poorly structured systems, the study of which by traditional methods is significantly difficult. To solve the problems of regulating the agri-food market, it is proposed to use cognitive modeling methods, which allows us to justify the need and adequacy of the use of additional tools of state regulation aimed at stimulating consumer demand.
Use of plasmolysed yeast to encapsulate and enhance the bioavailability of plant antioxidants
Authors: Kalinina Irina Valer'evna , Fatkullin Rinat Il'gidarovich , Naumenko Natalia
Published: January 2024

Abstract. The yeast Saccharomyces cerevisiae is widely used in many fermentative processes of food production. At the same time, the spent yeast biomass obtained after production processes generates significant amounts of waste. Thus, in the brewing industry residual brewer's yeast is the second largest volume of waste, which is about 3% of the volume of brewed beer. Utilization of these wastes is rather complicated and requires additional costs from the enterprises. Under these conditions, the directions of additional utilization of spent yeast mass are of high interest. One of such directions can be the use of plasmolysis of spent yeast and its further use for encapsulation of biologically active substances. Among biologically active compounds, plant polyphenols – substances with pronounced antioxidant properties – occupy an important place. Scientific novelty. This study examines dihydroquercetin, rutin and curcumin in their original and nanostructured forms. For these compounds an extensive list of pharmacological properties such as anti-inflammatory, antioxidant, capillaroprotective and others has been established. At the same time, these compounds are characterized by a low level of bioavailability. The purpose of the study was to investigate the possibility of using spent, plasmolysed cells of brewer's yeast Saccharomyces to encapsulate plant polyphenols: dihydroquercetin, rutin and curcumin, and to evaluate the effect of such an approach on the bioavailability of biologically active substances in an in vitro digestion model. Results. As a result of these studies, it was found that plasmolysed yeast cells are able to act as a “delivery system” of plant antioxidants. Using the proposed approaches, it is possible to achieve an encapsulation efficiency of approximately 57–64 %, provided that the polyphenols are ultrasonically nanostructured beforehand. Analysis of the potential bioavailability of encapsulated forms of plant antioxidants in an in vitro gastric digestion model showed that the technology of encapsulation into yeast cells allowed to ensure the preservation of plant antioxidants about 80 %. In comparison with the initial forms of biologically active substances, encapsulation allowed to provide an increase in bioavailability by about 30–40 %.
Features of feeding young rabbits
Authors: Kvartnikova Elizaveta , Kosovskiy G , Krovina Elena
Published: January 2024

Abstract. Domestic industrial rabbit breeding after 30 years of stagnation is beginning to gain momentum. Rabbit breeding is a well-developed branch of animal husbandry all over the world. An essential condition for the success of animal husbandry is the correctness of the organization of feeding, since in the cost of production, the cost of feeding reaches 60–70 %.The basis of the organization of feeding of all types of farm animals, including rabbits, is to determine their nutritional and energy needs. The feeding of young rabbits attracts special attention of scientists, since its energy demand is 3.4 times higher than that of adult animals during reproduction. Scientific research of domestic and foreign scientists on feeding young rabbits is very fragmented. The scheme of three-breed rabbit crossing has been developed at the Afanas`ev Research Institute of Fur – Bearing Animal Breeding and Rabbit Breeding on the basis of which the first domestic precocious and highly productive cross “Rodnik” was created. The relevance of the study lies in the need to create optimal diets for highly productive rabbit crosses. The purpose of the study is to study and analyze the achievements of domestic and foreign rabbit scientists contributing to the development of optimal diets for highly productive rabbit crosses. The novelty of the research lies in the fact that the analysis of new knowledge obtained by different scientific schools makes it possible to choose the direction of creating optimal diets for young rabbits. The results of the study. It has been established that the physiological features of rabbit digestion indicate the direction to the creation of diets optimized in terms of the ratio of nutrients, allowing to reduce the cost of feeding by 34 %. Probably, the need for nutrients and energy of new highly productive and precocious rabbit crosses will differ from the needs of meat-skinned breeds, as a result of which there will be a need to create individual diets.
Micropropagation of Pomegranate (Punica granatum L.) ‘Ganesh’ cultivar from nodal explants.
Authors: Thorat M , Taur Rupali
Published: January 2024

The present study was carried out to develop a rapid in vitro multiplication protocol using nodal explants. Complete plantlets have been successfully regenerated from node explants. The explants were incubated on Murashige and Skoog (MS) culture medium supplemented with different combinations of 6-benzyl amino purine (BAP) Indole acetic acid (IAA) and kinetin. Multiplication of node explants was achieved on BAP while from other combinations of growth hormone,. The response of various growth regulators was investigated. The combination of       showed the highest rate of shoot induction (100%) and a shoot regenerated about 6 shoots per explants when cultured on MS media supplemented with BAP (4 µM) within 2 weeks. The multiple elongated shoots were obtained on MS basal medium combination of Activated charcoal and growth hormones. Well-developed roots were achieved on MS medium in combination with BAP and IAA as well as 80% of plantlets were survived in the soil successfully in the hardening process. A robust and optimized protocol will be helpful for the mass production of this economical important  fruit .
ANALISIS PERBEDAAN PENDAPATAN USAHATANI KELAPA SAWIT VARIETAS DURA DENGAN USAHATANI KELAPA SAWIT VARIETAS TENERA DI DESA BUDI ASIH KECAMATAN PULAU RIMAU KABUPATEN BANYUASIN PROVINSI SUMATERA SELATAN
Authors: Sugiharto Bambang Bayuaji , Iswarini Harniatun
Published: January 2024

ABSTRACTThe purpose of this study was to determine the amount of income between the two varieties, to determine the difference in income between oil palm farming of the dura variety and coconut farming of the tenera variety. location is done intentionally. The research method used in this study is a quantitative method, the sampling method used in this study is proportional random sampling, by taking a sample of 20 respondents from oil palm farmers of the Tenera variety and 15 people from oil palm farmers of the Dura variety. The data taken are primary data and secondary data. The data processing method used is a quantitative method. The results showed that the average income of oil palm farmers with the Dura variety was Rp. 2,825,870 (Rp/lg/month), while oil palm farming with the Tenera variety averaged Rp. 6,059,467 (Rp/lg/month). . This shows that oil palm farmers with the tenera variety get higher incomes than the oil palm farmers with the dura variety and based on the results of the Independent t-test test, the sig value. (2-tailed) 0.001 < 0.05 for oil palm farmers of the Dura variety and 0.000 < 0.05 for rubber farmers of the Tenera variety showed that there was a difference in income for growing oil palm varieties with the Tenera variety and farm income for growing oil palm varieties for the Dura variety. ABSTRAKTujuan penelitian ini adalah untuk mengetahui besarnya pendapatan antara kedua varietas tersebut, untuk mengetahui perbedaan pendapatan antara usahatani kelapa sawit varietas dura dan usahatani kelapa sawit varietas tenera. Penentuan lokasi dilakukan dengan cara sengaja. Metode penelitian yang digunakan pada penelitian ini adalah metode kuantitatif, metode penarikan contoh yang digunakan dalam penelitian ini adalah proporsional random sampling, dengan mengambil sampel sebanyak 20 orang responden dari petani kelapa sawit varietas Tenera dan 15 orang dari petani kelapa sawit varietas Dura. Data yang diambil adalah data primer dan data sekunder. Metode pengolahan data yang digunakan adalah metode kuantitatif. Hasil penelitian menunjukkan Besar pendapatan petani kelapa sawit varietas dura rata-rata sebesar sebesar Rp.2.825.870 (Rp/lg/bln), sedangkan usahatani kelapa sawit dengan varietas Tenera rata-rata sebesar Rp.6.059.467 (Rp/lg/bln). Hal ini menunjukkan bahwa petani kelapa sawit dengan varietas tenera mempunyai pendapatan lebih tinggi dibandingkan dengan petani kelapa sawit varietas dura dan berdasarkan hasil pengujian Independent t-tes nilai sig. (2- tailed) 0.001 < 0.05 untuk petani kelapa sawit varietas Dura dan 0,000 < 0,05 untuk petani karet varietas Tenera menunjukkan bawa terdapat perbedaan pendapatan usahatani yang menanam kelapa sawit varietas tenera dengan pendapatan usahatani yang menanam kelapa sawit varietas dura.
Persepsi masyarakat tentang dampak sosial ekonomi dan lingkungan hadirnya PT Riau Andalan Pulp and Paper (RAPP) di Kelurahan Pangkalan Kerinci Timur
Authors: Situmorang Putri Insani , Purwanti Emi
Published: January 2024

Pertumbuhan ekonomi bidang industri tidak hanya memberikan dampak positif tetapi juga memberi peluang memberikan dampak negatif terhadap masyarakat. Pembangunan industri berkontribusi pada pertumbuhan wilayah melalui aspek ekonomi, lingkungan dan sosial. Penelitian bertujuan melihat persepsi masyarakat terkait dampak sosial ekonomi dan lingkungan hadirnya industri PT RAPP di masyarakat. Pendekatan penelitian secara analisis deskriptif kualitatif dengan Skala Likert. Responden sebanyak 60 orang yang bekerja di PT RAPP dan yang tidak bekerja di PT RAPP. Hasil penelitian menunjukkan kehadiran perusahaan mempengaruhi kondisi sosial, ekonomi dan lingkungan masyarakat. Indikator kondisi sosial berupa pendidikan, kesehatan, akses transportasi serta kelembagaan sosial hasil skoring sebesar 4,30 atau kategori sangat baik. Kondisi ekonomi ditunjukkan dengan indikator berupa peningkatan pendapatan dan kesempatan kerja pada masyarakat yang mendorong peningkatan kesejahteraan masyarakat dan menjadikan kehidupan menjadi lebih baik, nilai skoring yang diperoleh rataan 4,37 yang masuk ke dalam kriteria sangat baik. Namun demikian, hadirnya industri tersebut dirasakan masyarakat dapat memberikan dampak negatif terhadap kondisi lingkungan yaitu terjadinya pencemaran udara serta kurangnya jumlah air bersih yang ditunjukkan dengan nilai skoring sebesar 2,91 atau kategori kurang baik.
Problems of implementation by insurers of the right of recourse to the person who caused the damage
Authors:   Turan University, Bayan M. , Ospanova D.A. ,   Turan University, Plotskaya O.А. ,   Plekhanov Russian University of Economics, Institute of Management Technologies of the Federal State Budgetary Educational Institution of Higher Education “MIREA - Russian Technological University”
Published: January 2024

The authors of this article analyze the current legislation in the field of civil liability insurance of vehicle owners in terms of the use of the insurers’ right of recourse to the person who caused the damage. Article 28 of the Law “On Compulsory Insurance of Civil Liability of Vehicle Owners” dated July 1, 2003 regulates the recovery of insurance payment by way of recourse (regress claims). Analysis of the practice of implementation by insurers of this right in court has revealed some shortcomings and imperfections of the Article 28 of the Law under consideration. As a result, the authors of the article offer recommendations for improving the rules governing the relations associated with the implementation by insurers of their right of recourse to the insured (insured).The introduction of the institution of compulsory insurance of civil liability of vehicle owners has significantly reduced the burden on the judicial system in terms of disputes on recovery of damage caused as a result of a traffic accident. However, in the judicial practice on this type of insurance, many questions arise. The recommendations in the article are based on the results of court disputes involving the author of the article.
The institute of the ombudsman (commissioner for human rights) in the public power system
Authors:   Akhmet Yassawi International Kazakh-Turkish University, Ashirbekova A.B. , Abikenov А.А. ,   Al-Farabi Kazakh National University, Saktaganova I.S. ,   L.N. Gumilyov Eurasian National University
Published: January 2024

The ombudsman institution plays an important role in the system of state bodies that ensure the rights and freedoms of people and citizens. In the article, in the context of the theory of separation of state power, the issue of the legal features of the ombudsman (human rights commissioner) in the system of state bodies raised. In addition, the concept and meaning of the ombudsman institution is revealed, and its place in the system of state authorities is analyzed. Three models of the ombudsman institute working in the states in modern times describes executive, independent and parliamentary. The purpose of the article is to determine its position in the system of state power by studying the legal status of the ombudsman institution, based on the norms established in national legislation. The works of foreign and domestic scientists who made a significant contribution to the study of the history of the formation and development of the Ombudsman Institute noted. Research methods of the Human Rights Ombudsman Institute described. In addition, the legal status of the ombudsman (Human Rights Commissioner) is described based on the articles of the Constitutional Law “On Human Rights Commissioner in the Republic of Kazakhstan” adopted on November 5, 2022.
Selected issues of participation of persons with disabilities in public procurements in the Republic of Kazakhstan
Authors:   Suleyman Demirel University, Tursynova B.B. , Makhmadinov D.M. ,   Suleyman Demirel University
Published: January 2024

Many countries around the world are actively incorporating elements of sustainability in their public procurement contracts. One of these elements is the social aspect that allows states to deal with the unemployment of persons with disabilities while also ensuring that their needs for goods and services are met. To achieve the above goal, the state, when conducting public procurement, provides certain advantages to public associations of persons with disabilities of the Republic of Kazakhstan and (or) organizations that are created by public associations of persons with disabilities of the Republic of Kazakhstan, provided that they produce goods and (or) supply goods, perform work, provide services. This article examines the procedure for legal regulation and provision of advantages to certain categories of participants in public procurement and identifies gaps that affect the possibility and effectiveness of their participation to improve the current state that involves such persons who participate in public procurement. The article draws conclusions from the problems of unfair use of benefits of the state for persons with disabilities by other persons who do not have the right to it, and also considering various schemes for withdrawing funds. In other terms, the current legislation which was aimed to satisfy the needs of persons with disabilities giving opportunities to exercise their rights has not been achieved. The article also promotes the idea to provide benefits for categories of social entrepreneurship entities and organizations whose activities are aimed at solving social problems through their participation in public procurement.
Patient Centered Care (PCC) dalam Dokumentasi Keperawatan
Authors: Bawuno Vinny Vionita , Erika Kadek Ayu , Syam Yuliana
Published: January 2024

Pelayanan keperawatan harus berfokus pada pasien/patient centered care (PCC) dengan mengedepankan respon terhadap kebutuhan, nilai, keyakinan serta pilihan pasien. Dokumentasi keperawatan merupakan media komunikasi non verbal yang berperan penting dalam keberhasilan PCC, oleh sebab itu diperlukan tinjauan terkait PCC dalam dokumentasi keperawatan. Studi ini bertujuan untuk mengidentifikasi dan mensintesis hasil penelitian terkait dokumentasi keperawatan berdasarkan PCC. Digunakan metode pendekatan literature review dengan pencarian artikel pada enam basis data elektronik: PubMed, EBSCO, Cochrane Library, ProQuest, Scopus dan DOAJ. Teridentifikasi 262 artikel, yang kemudian dilakukan skrining berdasarkan kriteria inklusi berupa original artikel, sampel perawat, pasien maupun dokumentasi keperawatan PCC, diterbitkan dalam kurun waktu sepuluh tahun terakhir atau rentang tahun 2012 sampai tahun 2022, serta berbahasa Inggris. Hasil menunjukkan, lima studi memenuhi kriteria inklusi, termasuk empat studi kualitatif dan satu studi cross-sectional. Empat studi melaporkan variasi dalam kelengkapan pendokumentasian PCC, tiga studi menyoroti faktor-faktor, hambatan maupun tantangan dalam pendokumentasian PCC, serta dua studi menyimpulkan strategi dan rekomendasi terkait upaya peningkatan dokumentasi keperawatan PCC. Kajian ini menemukan wawasan baru yang komprehensif terkait rendahnya pelaksanaan dokumentasi PCC, tantangan, hambatan dan faktor penyebab, serta upaya peningkatan dokumentasi keperawatan PCC. Sehingga ini dapat berguna untuk rencana pengembangan strategi pendokumentasian berdasarkan PCC.