bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Authors: Tuccillo Franca Maria , Palmieri Camillo , Fiume Giuseppe , de Laurentiis Annamaria , Schiavone Marco , Falcone Cristina , Iaccino Enrico , Galandrini Ricciarda , Capuano Cristina , Santoni Angela , D'Armiento Francesco Paolo , Arra Claudio , Barbieri Antonio , Dal Piaz Fabrizio , Venzon David , Bonelli Patrizia , Buonaguro Franco Maria , Scala Iris , Mallardo Massimo , Quinto Ileana , Scala Giuseppe
Published: April 2023

PDF file - 470K, Figure S1. UN1 mAb did not affect the proliferation rate, cell cycle, viability and apoptosis of HPB-ALL cells. Figure S2. The 2/165 phage clone and synthetic peptides do not inhibit the binding of mAb W6/32 to HPB-ALL cells. Supplementary Figure S3. Competition of the UN1 mAb-binding to UN1-positive breast and gastric cancer tissues by the 2/165 phage and G23 peptide. Figure S4. Characterization of affinity-purified antibodies from sera of 2/165 phagotopeimmunized mice.
Supplementary Table 1 from Anetumab Ravtansine: A Novel Mesothelin-Targeting Antibody–Drug Conjugate Cures Tumors with Heterogeneous Target Expression Favored by Bystander Effect
Authors: Golfier Sven , Kopitz Charlotte , Kahnert Antje , Heisler Iring , Schatz Christoph A. , Stelte-Ludwig Beatrix , Mayer-Bartschmid Anke , Unterschemmann Kerstin , Bruder Sandra , Linden Lars , Harrenga Axel , Hauff Peter , Scholle Frank-Detlef , Müller-Tiemann Beate , Kreft Bertolt , Ziegelbauer Karl
Published: April 2023

PDF - 118K, Supplementary Table S1. Mesothelin staining intensity in FFPE tissues of human primary ovarian cancer, pancreatic cancer and mesothelioma.
Supplementary Materials and Methods and Supplementary Figure Legends from Anetumab Ravtansine: A Novel Mesothelin-Targeting Antibody–Drug Conjugate Cures Tumors with Heterogeneous Target Expression Favored by Bystander Effect
Authors: Golfier Sven , Kopitz Charlotte , Kahnert Antje , Heisler Iring , Schatz Christoph A. , Stelte-Ludwig Beatrix , Mayer-Bartschmid Anke , Unterschemmann Kerstin , Bruder Sandra , Linden Lars , Harrenga Axel , Hauff Peter , Scholle Frank-Detlef , Müller-Tiemann Beate , Kreft Bertolt , Ziegelbauer Karl
Published: April 2023

PDF - 117K, Supplementary materials and methods, figure legends for supplementary figures and table.
Supplementary Figure 1 from Small Molecule Inhibition of PAX3-FOXO1 through AKT Activation Suppresses Malignant Phenotypes of Alveolar Rhabdomyosarcoma
Authors: Jothi Mathivanan , Mal Munmun , Keller Charles , Mal Asoke K.
Published: April 2023

PDF file - 890K, Supplementary Figure S1. Validation of PAX3-FOXO1-mediated reporter luciferase activity in U20325-PRSLuc reporter cells and evidence displaying U20325 cells does not express PAX3.
Supplementary Table S1 from Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells
Authors: Tani Tetsuo , Yasuda Hiroyuki , Hamamoto Junko , Kuroda Aoi , Arai Daisuke , Ishioka Kota , Ohgino Keiko , Miyawaki Masayoshi , Kawada Ichiro , Naoki Katsuhiko , Hayashi Yuichiro , Betsuyaku Tomoko , Soejima Kenzo
Published: April 2023

The sequences primers used in this study
Supplementary Figures 1 - 10 from Combining Hedgehog Signaling Inhibition with Focal Irradiation on Reduction of Pancreatic Cancer Metastasis
Authors: Gu Dongsheng , Liu Hailan , Su Gloria H. , Zhang Xiaoli , Chin-Sinex Helen , Hanenberg Helmut , Mendonca Marc S. , Shannon Harlan E. , Chiorean E. Gabriela , Xie Jingwu
Published: April 2023

PDF file - 372K, Supplementary Figure 1 (Fig.S1)- Detection of CD24 transcript in AsPC1 cells, Supplementary Figure 2 (Fig.S2) Detection of Hh target genes in orthotopic pancreatic cancer models, Supplementary Figure 3 (Fig.S3) Expression of SHH and IHH in AsPC1-derived tumors, Supplementary Figure 4 (Fig.S4) Expression of mouse Hh target genes in AsPC1- and MIA PaCa2-derived tumors, Supplementary Figure 5 (Fig.S5) Picture of tumor spheres (100X) from AsPC1-derived pancreatic tumors or lymph node metastases, Supplementary Figure 6 (Fig.S6) Effect of CycT on tumor sphere regeneration, Supplementary Figure 7 (Fig.S7) Effects of combining radiation with Hh signaling inhibition on tumor sphere regeneration of MMC16 cells, Supplementary Figure 8 (Fig.S8) Effects of Hh signaling inhibitor BMS833923 on Hh target gene expression in AsPC1 derived orthotopic model, Supplementary Figure 9 (Fig.S9) Effects of irradiation and Hh signaling inhibitor BMS (BMS833932) on lung metastasis, Supplementary Figure 10 (Fig.S10) Regulation of putative Hh target genes by Hh signaling inhibition in pancreatic cancer
Supplementary Figure Legend from Combining Hedgehog Signaling Inhibition with Focal Irradiation on Reduction of Pancreatic Cancer Metastasis
Authors: Gu Dongsheng , Liu Hailan , Su Gloria H. , Zhang Xiaoli , Chin-Sinex Helen , Hanenberg Helmut , Mendonca Marc S. , Shannon Harlan E. , Chiorean E. Gabriela , Xie Jingwu
Published: April 2023

PDF file - 94K
Supplementary Fig. S5 from Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells
Authors: Tani Tetsuo , Yasuda Hiroyuki , Hamamoto Junko , Kuroda Aoi , Arai Daisuke , Ishioka Kota , Ohgino Keiko , Miyawaki Masayoshi , Kawada Ichiro , Naoki Katsuhiko , Hayashi Yuichiro , Betsuyaku Tomoko , Soejima Kenzo
Published: April 2023

Induction of EGF and TGF in H3122 cells following alectinib treatment
Supplementary Figures S1-7 from Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks
Authors: Matsuoka Kazuaki , Iimori Makoto , Niimi Shinichiro , Tsukihara Hiroshi , Watanabe Sugiko , Kiyonari Shinichi , Kiniwa Mamoru , Ando Koji , Tokunaga Eriko , Saeki Hiroshi , Oki Eiji , Maehara Yoshihiko , Kitao Hiroyuki
Published: April 2023

Supplementary Figures S1-7. Supplementary Figure S1. The cellular response of RKO cells to IC50 concentration of FdUrd or FTD. Supplementary Figure S2. The cellular responses of A549 cells to IC50 concentration of FdUrd or FTD. Supplementary Figure S3. A549 cells either treated with siGL2 or siTP53 were cultured in the presence of IC50 concentration of FdUrd or FTD. Supplementary Figure S4. RKO (A) or A549 (B) cells were cultured in the presence of IC50 concentration of FdUrd or FTD. Supplementary Figure S5. Immunoflurorescent images of Cyclin B1 in exponentially growing (A) or FTD-treated (B,C) HCT-116 cells. Supplementary Figure S6. Immunoflurorescent images of Cyclin B1 in FTD-treated HCT-116 cells with or without MG132. Supplementary Figure S7. Representative images of alkaline or neutral comet assay in camptothecin-treated HCT-116 cells.
Supplementary Table 2 from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Authors: Knutson Sarah K. , Kawano Satoshi , Minoshima Yukinori , Warholic Natalie M. , Huang Kuan-Chun , Xiao Yonghong , Kadowaki Tadashi , Uesugi Mai , Kuznetsov Galina , Kumar Namita , Wigle Tim J. , Klaus Christine R. , Allain Christina J. , Raimondi Alejandra , Waters Nigel J. , Smith Jesse J. , Porter-Scott Margaret , Chesworth Richard , Moyer Mikel P. , Copeland Robert A. , Richon Victoria M. , Uenaka Toshimitsu , Pollock Roy M. , Kuntz Kevin W. , Yokoi Akira , Keilhack Heike
Published: April 2023

XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Supplementary Methods, Figure Legends from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Authors: Knutson Sarah K. , Kawano Satoshi , Minoshima Yukinori , Warholic Natalie M. , Huang Kuan-Chun , Xiao Yonghong , Kadowaki Tadashi , Uesugi Mai , Kuznetsov Galina , Kumar Namita , Wigle Tim J. , Klaus Christine R. , Allain Christina J. , Raimondi Alejandra , Waters Nigel J. , Smith Jesse J. , Porter-Scott Margaret , Chesworth Richard , Moyer Mikel P. , Copeland Robert A. , Richon Victoria M. , Uenaka Toshimitsu , Pollock Roy M. , Kuntz Kevin W. , Yokoi Akira , Keilhack Heike
Published: April 2023

PDF file - 130K
Supplementary Table 1 from Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer
Authors: Gharpure Kshipra M. , Chu Kevin S. , Bowerman Charles J. , Miyake Takahito , Pradeep Sunila , Mangala Selanere L. , Han Hee-Dong , Rupaimoole Rajesha , Armaiz-Pena Guillermo N. , Rahhal Tojan B. , Wu Sherry Y. , Luft J. Christopher , Napier Mary E. , Lopez-Berestein Gabriel , DeSimone Joseph M. , Sood Anil K.
Published: April 2023

PDF - 312K, Storage stability of PLGA-PRINT nanoparticles.
Supplementary Materials and Methods and Supplementary Figure Legends from Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer
Authors: Gharpure Kshipra M. , Chu Kevin S. , Bowerman Charles J. , Miyake Takahito , Pradeep Sunila , Mangala Selanere L. , Han Hee-Dong , Rupaimoole Rajesha , Armaiz-Pena Guillermo N. , Rahhal Tojan B. , Wu Sherry Y. , Luft J. Christopher , Napier Mary E. , Lopez-Berestein Gabriel , DeSimone Joseph M. , Sood Anil K.
Published: April 2023

PDF - 78K, Supplementary methods and legends for supplementary figures.
Supplementary Figure Legend and Supplementary Tables 1 and 2 from Mutant Ras Elevates Dependence on Serum Lipids and Creates a Synthetic Lethality for Rapamycin
Authors: Salloum Darin , Mukhopadhyay Suman , Tung Kaity , Polonetskaya Aleksandra , Foster David A.
Published: April 2023

PDF - 186K, Figure legend for Supp Fig. 1. Table S1: Composition of fatty acid mixture. Table S2: Cell Cycle Distribution of Cells Treated with Rapamycin and EIPA.
Supplementary Figure 3 from Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by DDR2 Gatekeeper Mutation and NF1 Loss
Authors: Beauchamp Ellen M. , Woods Brittany A. , Dulak Austin M. , Tan Li , Xu Chunxiao , Gray Nathanael S. , Bass Adam J. , Wong Kwok-kin , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF - 36KB, Sensitivity of NCI-H2286 and NCI-H2286-DR to MEK inhibitor is unchanged in the presence or absence of dasatinib.
Supplementary Materials and Methods, Tables 1-2 and Figure Legends from Pharmacodynamic and Antineoplastic Activity of BI 836845, a Fully Human IGF Ligand-Neutralizing Antibody, and Mechanistic Rationale for Combination with Rapamycin
Authors: Friedbichler Katrin , Hofmann Marco H. , Kroez Monika , Ostermann Elinborg , Lamche Herbert R. , Koessl Christian , Borges Eric , Pollak Michael N. , Adolf Günther , Adam Paul J.
Published: April 2023

PDF - 124KB, Supplementary Materials and Methods describing 2D cell viability assays, Western blot and qRT-PCR analyses, and determination of total rat serum IGF-1 levels and ex vivo IGF-1 bioactivity; Supplementary Table 1 (summary of BI 836845 binding characteristics) and Supplementary Table 2 (sequences of qRT-PCR primers/probes) and Supplementary Figure Legends to Supplementary Figures 1-3.
Supplementary Figure 1 from Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by DDR2 Gatekeeper Mutation and NF1 Loss
Authors: Beauchamp Ellen M. , Woods Brittany A. , Dulak Austin M. , Tan Li , Xu Chunxiao , Gray Nathanael S. , Bass Adam J. , Wong Kwok-kin , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF - 96KB, Dasatinib treatment results in dephosphorylation of DDR2 in parental lines but not in parental lines expressing DDR2 T654I. This dephosphorylation is also observed following dasatinib treatment in NCI-H2286-DR but not in HCC-366-DR.
Supplementary Materials and Methods, Figure Legends from Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Authors: Garcia Khristofer , Blank Jonathan L. , Bouck David C. , Liu Xiaozhen J. , Sappal Darshan S. , Hather Greg , Cosmopoulos Katherine , Thomas Michael P. , Kuranda Mike , Pickard Michael D. , Liu Ray , Bandi Syamala , Smith Peter G. , Lightcap Eric S.
Published: April 2023

PDF file - 68KB
Supplementary Table 1 from Blockade of mTOR Signaling via Rapamycin Combined with Immunotherapy Augments Antiglioma Cytotoxic and Memory T-Cell Functions
Authors: Mineharu Yohei , Kamran Neha , Lowenstein Pedro R. , Castro Maria G.
Published: April 2023

Supplementary Table 1: Rat and mouse specific antibodies
Supplementary Figure 5 from Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Authors: Garcia Khristofer , Blank Jonathan L. , Bouck David C. , Liu Xiaozhen J. , Sappal Darshan S. , Hather Greg , Cosmopoulos Katherine , Thomas Michael P. , Kuranda Mike , Pickard Michael D. , Liu Ray , Bandi Syamala , Smith Peter G. , Lightcap Eric S.
Published: April 2023

PDF file - 159KB, The Combination of MLN4924 and Mitomycin C Results in a BRCA1-dependent Activation of ATR following Induction of DNA Strand Breaks.
Supplementary Figure 3 from Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Authors: Garcia Khristofer , Blank Jonathan L. , Bouck David C. , Liu Xiaozhen J. , Sappal Darshan S. , Hather Greg , Cosmopoulos Katherine , Thomas Michael P. , Kuranda Mike , Pickard Michael D. , Liu Ray , Bandi Syamala , Smith Peter G. , Lightcap Eric S.
Published: April 2023

PDF file - 339KB, Comparison of Isobolograms Calculated for Drug Response Surface Plots for 10 Different Agents.
Supplementary Figure 3 from Blockade of mTOR Signaling via Rapamycin Combined with Immunotherapy Augments Antiglioma Cytotoxic and Memory T-Cell Functions
Authors: Mineharu Yohei , Kamran Neha , Lowenstein Pedro R. , Castro Maria G.
Published: April 2023

Supplementary Figure 3: Phenotype of Flt3L derived murine BMDCs
Supplementary Figure 2 from Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Authors: Garcia Khristofer , Blank Jonathan L. , Bouck David C. , Liu Xiaozhen J. , Sappal Darshan S. , Hather Greg , Cosmopoulos Katherine , Thomas Michael P. , Kuranda Mike , Pickard Michael D. , Liu Ray , Bandi Syamala , Smith Peter G. , Lightcap Eric S.
Published: April 2023

PDF file - 664KB, Sensitivity of Cancer Cell Lines to DNA Damaging Agents.
Supplementary Figure 2 from Blockade of mTOR Signaling via Rapamycin Combined with Immunotherapy Augments Antiglioma Cytotoxic and Memory T-Cell Functions
Authors: Mineharu Yohei , Kamran Neha , Lowenstein Pedro R. , Castro Maria G.
Published: April 2023

Supplementary Figure 2: Effect of Rapamycin on GL26 and RG2 cells
Supplementary Figure 1 from Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Authors: Garcia Khristofer , Blank Jonathan L. , Bouck David C. , Liu Xiaozhen J. , Sappal Darshan S. , Hather Greg , Cosmopoulos Katherine , Thomas Michael P. , Kuranda Mike , Pickard Michael D. , Liu Ray , Bandi Syamala , Smith Peter G. , Lightcap Eric S.
Published: April 2023

PDF file - 1215KB, Full Length Western Blots.
Supplementary Figure 1 from Blockade of mTOR Signaling via Rapamycin Combined with Immunotherapy Augments Antiglioma Cytotoxic and Memory T-Cell Functions
Authors: Mineharu Yohei , Kamran Neha , Lowenstein Pedro R. , Castro Maria G.
Published: April 2023

Supplementary Figure 1: Flow analysis showing Annexin V and PI stains
Supplementary Figure Legend from Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
Authors: Carlino Matteo S. , Gowrishankar Kavitha , Saunders Catherine A.B. , Pupo Gulietta M. , Snoyman Stephanie , Zhang Xu Dong , Saw Robyn , Becker Therese M. , Kefford Richard F. , Long Georgina V. , Rizos Helen
Published: April 2023

PDF file - 81K
Supplementary Figure 6 from Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
Authors: Carlino Matteo S. , Gowrishankar Kavitha , Saunders Catherine A.B. , Pupo Gulietta M. , Snoyman Stephanie , Zhang Xu Dong , Saw Robyn , Becker Therese M. , Kefford Richard F. , Long Georgina V. , Rizos Helen
Published: April 2023

PDF file - 452K, Identification of BRAFV600E splice variant lacking exons 2-10 in dabrafenib resistant WMD009 tumour and derived cell line.
Supplementary Figure 1 from Biochemical Assays for the Discovery of TDP1 Inhibitors
Authors: Marchand Christophe , Huang Shar-yin N. , Dexheimer Thomas S. , Lea Wendy A. , Mott Bryan T. , Chergui Adel , Naumova Alena , Stephen Andrew G. , Rosenthal Andrew S. , Rai Ganesha , Murai Junko , Gao Rui , Maloney David J. , Jadhav Ajit , Jorgensen William L. , Simeonov Anton , Pommier Yves
Published: April 2023

PDF - 119K, Schematic representation of the AlphaScreen 3'-phospho-tyrosine DNA substrate used in the TDP1 qHTS assay.
Supplementary Figure 5 from Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
Authors: Carlino Matteo S. , Gowrishankar Kavitha , Saunders Catherine A.B. , Pupo Gulietta M. , Snoyman Stephanie , Zhang Xu Dong , Saw Robyn , Becker Therese M. , Kefford Richard F. , Long Georgina V. , Rizos Helen
Published: April 2023

PDF file - 918K, MAPK inhibitor treatment does not induce apoptosis in MAPK inhibitor resistant patient derived cell lines.
Supplementary Figure 4 from Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
Authors: Carlino Matteo S. , Gowrishankar Kavitha , Saunders Catherine A.B. , Pupo Gulietta M. , Snoyman Stephanie , Zhang Xu Dong , Saw Robyn , Becker Therese M. , Kefford Richard F. , Long Georgina V. , Rizos Helen
Published: April 2023

PDF file - 5091K, CT scans illustrating growth of subcutaneous lesion while on MAPK inhibitor treatment.
Supplementary Table Legend from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer
Authors: Fu Maoyong , Maresh Erin L. , Helguera Gustavo F. , Kiyohara Meagan , Qin Yu , Ashki Negin , Daniels-Wells Tracy R. , Aziz Najib , Gordon Lynn K. , Braun Jonathan , Elshimali Yahya , Soslow Robert A. , Penichet Manuel L. , Goodglick Lee , Wadehra Madhuri
Published: April 2023

PDF - 55K, Legends for Supplementary Tables 1 through 5.
Supplementary Materials and Methods from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer
Authors: Fu Maoyong , Maresh Erin L. , Helguera Gustavo F. , Kiyohara Meagan , Qin Yu , Ashki Negin , Daniels-Wells Tracy R. , Aziz Najib , Gordon Lynn K. , Braun Jonathan , Elshimali Yahya , Soslow Robert A. , Penichet Manuel L. , Goodglick Lee , Wadehra Madhuri
Published: April 2023

PDF - 68K, Supplementary Materials and Methods.
Supplementary Figure 2 from Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
Authors: Carlino Matteo S. , Gowrishankar Kavitha , Saunders Catherine A.B. , Pupo Gulietta M. , Snoyman Stephanie , Zhang Xu Dong , Saw Robyn , Becker Therese M. , Kefford Richard F. , Long Georgina V. , Rizos Helen
Published: April 2023

PDF file - 1142K, Resistant melanoma sub-lines display a diminished proliferative transcriptome signatured when exposed to MAPK inhibitors.
Supplementary Figures 1 and 2 from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer
Authors: Fu Maoyong , Maresh Erin L. , Helguera Gustavo F. , Kiyohara Meagan , Qin Yu , Ashki Negin , Daniels-Wells Tracy R. , Aziz Najib , Gordon Lynn K. , Braun Jonathan , Elshimali Yahya , Soslow Robert A. , Penichet Manuel L. , Goodglick Lee , Wadehra Madhuri
Published: April 2023

PDF - 855K, Supplementary Figure 1. Anti- EMP2 IgG1 can detect EMP2 in human tissue. Supplementary Figure 2. The serum levels of the human EMP2 IgG1 was compared to those of Trastuzamab.
Supplementary Figure 1 from Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
Authors: Carlino Matteo S. , Gowrishankar Kavitha , Saunders Catherine A.B. , Pupo Gulietta M. , Snoyman Stephanie , Zhang Xu Dong , Saw Robyn , Becker Therese M. , Kefford Richard F. , Long Georgina V. , Rizos Helen
Published: April 2023

PDF file - 2188K, Melanoma sub-lines with acquired resistance to MAPK inhibition, survive in the presence of MAPK inhibitor.
Supplementary Figure Legend from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer
Authors: Fu Maoyong , Maresh Erin L. , Helguera Gustavo F. , Kiyohara Meagan , Qin Yu , Ashki Negin , Daniels-Wells Tracy R. , Aziz Najib , Gordon Lynn K. , Braun Jonathan , Elshimali Yahya , Soslow Robert A. , Penichet Manuel L. , Goodglick Lee , Wadehra Madhuri
Published: April 2023

PDF - 37K, Legends for Supplementary Figures 1 and 2
Supplementary Table 2 from Mechanism of Differentiation-Enhanced Photodynamic Therapy for Cancer: Upregulation of Coproporphyrinogen Oxidase by C/EBP Transcription Factors
Authors: Anand Sanjay , Hasan Tayyaba , Maytin Edward V.
Published: April 2023

PDF file - 64K, Effect of mutations in the mCPO upstream region upon C/EBP-induced promoter activity.
Supplementary Methods, Figure Legend from Preclinical Characterization of AMG 330, a CD3/CD33-Bispecific T-Cell–Engaging Antibody with Potential for Treatment of Acute Myelogenous Leukemia
Authors: Friedrich Matthias , Henn Anja , Raum Tobias , Bajtus Monika , Matthes Katja , Hendrich Larissa , Wahl Joachim , Hoffmann Patrick , Kischel Roman , Kvesic Majk , Slootstra Jerry W. , Baeuerle Patrick A. , Kufer Peter , Rattel Benno
Published: April 2023

PDF file - 24KB
Supplementary Figure Legend from Mechanism of Differentiation-Enhanced Photodynamic Therapy for Cancer: Upregulation of Coproporphyrinogen Oxidase by C/EBP Transcription Factors
Authors: Anand Sanjay , Hasan Tayyaba , Maytin Edward V.
Published: April 2023

PDF file - 49K
Supplementary Figures 1 and 2 from New Insights into PARP Inhibitors' Effect on Cell Cycle and Homology-Directed DNA Damage Repair
Authors: Jelinic Petar , Levine Douglas A.
Published: April 2023

PDF - 615K, Supplemental Figure 1. Apoptosis assessment in olaparib- and veliparib-treated cells. Supplemental Figure 2. Assessment of PJ34-treated cells.
Supplementary Figure 1 from Mechanism of Differentiation-Enhanced Photodynamic Therapy for Cancer: Upregulation of Coproporphyrinogen Oxidase by C/EBP Transcription Factors
Authors: Anand Sanjay , Hasan Tayyaba , Maytin Edward V.
Published: April 2023

PDF file - 1072K, C/EBP consensus sites in other genes from the literature.
Supplementary Table 1 from TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression
Authors: Zhu Jin , Yang Dong-Rong , Sun Yin , Qiu Xiaofu , Chang Hong-Chiang , Li Gonghui , Shan Yuxi , Chang Chawnshang
Published: April 2023

30 metastasis-related genes used for screening.
Supplementary Table 4 from Selective Activity of the Histone Deacetylase Inhibitor AR-42 against Leukemia Stem Cells: A Novel Potential Strategy in Acute Myelogenous Leukemia
Authors: Guzman Monica L. , Yang Neng , Sharma Krishan K. , Balys Marlene , Corbett Cheryl A. , Jordan Craig T. , Becker Michael W. , Steidl Ulrich , Abdel-Wahab Omar , Levine Ross L. , Marcucci Guido , Roboz Gail J. , Hassane Duane C.
Published: April 2023

PDF - 962K, Reactome gene list.
Supplementary Figure 2 from TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression
Authors: Zhu Jin , Yang Dong-Rong , Sun Yin , Qiu Xiaofu , Chang Hong-Chiang , Li Gonghui , Shan Yuxi , Chang Chawnshang
Published: April 2023

Morphology change of C4-2 S/P cells transfected with TR4 shRNA. C4-2 CD133+ S/P cells with TR4 knock down (B) showed morphology change to more differentiated PCa cells than control group (A).
Supplementary Figure 1 from TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression
Authors: Zhu Jin , Yang Dong-Rong , Sun Yin , Qiu Xiaofu , Chang Hong-Chiang , Li Gonghui , Shan Yuxi , Chang Chawnshang
Published: April 2023

Quantitation for Western Blot data. A. Quantitation for Fig. 1C/D. B. Quantitation for Fig. 2A/D. C. Quantitation for Fig. 3D. D. Quantitation for Fig. 5A.
Supplementary Figure 6 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Authors: You Shuo , Li Rui , Park Dongkyoo , Xie Maohua , Sica Gabriel L. , Cao Ya , Xiao Zhi-Qiang , Deng Xingming
Published: April 2023

PDF file - 181K, Toxicity analysis for treatments with IR and niclosamide in mice bearing A549-IRR xenografts.
Supplementary Figure 4 from Selective Activity of the Histone Deacetylase Inhibitor AR-42 against Leukemia Stem Cells: A Novel Potential Strategy in Acute Myelogenous Leukemia
Authors: Guzman Monica L. , Yang Neng , Sharma Krishan K. , Balys Marlene , Corbett Cheryl A. , Jordan Craig T. , Becker Michael W. , Steidl Ulrich , Abdel-Wahab Omar , Levine Ross L. , Marcucci Guido , Roboz Gail J. , Hassane Duane C.
Published: April 2023

PDF - 107K, AR-42, unlike PTL, does not upregulate HMOX-1 as a consequence of ROS induction.
Supplementary Figure 5 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Authors: You Shuo , Li Rui , Park Dongkyoo , Xie Maohua , Sica Gabriel L. , Cao Ya , Xiao Zhi-Qiang , Deng Xingming
Published: April 2023

PDF file - 142K, Niclosamide or in combination with IR inhibits cell proliferation in tumor tissues.
Supplementary Figure 3 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Authors: You Shuo , Li Rui , Park Dongkyoo , Xie Maohua , Sica Gabriel L. , Cao Ya , Xiao Zhi-Qiang , Deng Xingming
Published: April 2023

PDF file - 190K, Niclosamide increases the proportion of the cell population in the G0/G1 phase in A549 parental and radioresistant A549 (A549-IRR) cells.
Supplementary Figure 2 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Authors: You Shuo , Li Rui , Park Dongkyoo , Xie Maohua , Sica Gabriel L. , Cao Ya , Xiao Zhi-Qiang , Deng Xingming
Published: April 2023

PDF file - 74K, Niclosamide (Niclo) reduces STAT3 nuclear localization in radioresistant human lung cancer A549-IRR cells.
Supplementary Figure 1 from Selective Activity of the Histone Deacetylase Inhibitor AR-42 against Leukemia Stem Cells: A Novel Potential Strategy in Acute Myelogenous Leukemia
Authors: Guzman Monica L. , Yang Neng , Sharma Krishan K. , Balys Marlene , Corbett Cheryl A. , Jordan Craig T. , Becker Michael W. , Steidl Ulrich , Abdel-Wahab Omar , Levine Ross L. , Marcucci Guido , Roboz Gail J. , Hassane Duane C.
Published: April 2023

PDF - 3879K, AR-42 gene expression signature displays similarity to PTL and HDAC inhibitors.
Supplementary Figure 1 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Authors: You Shuo , Li Rui , Park Dongkyoo , Xie Maohua , Sica Gabriel L. , Cao Ya , Xiao Zhi-Qiang , Deng Xingming
Published: April 2023

PDF file - 218K, Ionizing radiation (IR) induces activation of the JAK2/STAT3/Bcl2/Bcl-XL survival signaling pathway in various human lung cancer cells.
Supplementary Tables from TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer
Authors: Rajput Sandeep , Volk-Draper Lisa D. , Ran Sophia
Published: April 2023

Supplementary Tables - PDF file 134K, Supplementary Tables
Supplementary Table 1 from Decreased miR-340 Expression in Bone Marrow Is Associated with Liver Metastasis of Colorectal Cancer
Authors: Takeyama Hiroshi , Yamamoto Hirofumi , Yamashita Shinya , Wu Xin , Takahashi Hidekazu , Nishimura Junichi , Haraguchi Naotsugu , Miyake Yasuhiro , Suzuki Rei , Murata Kohei , Ohue Masayuki , Kato Takeshi , Takemasa Ichiro , Mizushima Tsunekazu , Ishii Hideshi , Mimori Koshi , Doki Yuichiro , Mori Masaki
Published: April 2023

PDF - 60K, Clinicopathologic factors of patients analyzed by miRNA array.
Supplementary Figure S3 from TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer
Authors: Rajput Sandeep , Volk-Draper Lisa D. , Ran Sophia
Published: April 2023

Supplementary Figure S3 - PDF file 379K, Generation of MDA-MB-231 (TLR4-) and HCC1806 (TLR4+) stably modified clones
Supplementary Figure 2 from Decreased miR-340 Expression in Bone Marrow Is Associated with Liver Metastasis of Colorectal Cancer
Authors: Takeyama Hiroshi , Yamamoto Hirofumi , Yamashita Shinya , Wu Xin , Takahashi Hidekazu , Nishimura Junichi , Haraguchi Naotsugu , Miyake Yasuhiro , Suzuki Rei , Murata Kohei , Ohue Masayuki , Kato Takeshi , Takemasa Ichiro , Mizushima Tsunekazu , Ishii Hideshi , Mimori Koshi , Doki Yuichiro , Mori Masaki
Published: April 2023

PDF - 150K, Over expression of miR-340 suppressed c-Met expression in HCT116 and SW480 in vitro.
Supplementary Figure S1 from TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer
Authors: Rajput Sandeep , Volk-Draper Lisa D. , Ran Sophia
Published: April 2023

Supplementary Figure S1 - PDF file 343K, Functional analysis of TLR4 protein in MDA-MB-231 cells
Supplementary Figure Legends from TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer
Authors: Rajput Sandeep , Volk-Draper Lisa D. , Ran Sophia
Published: April 2023

Supplementary Figure Legends - PDF file 88K, Supplementary Figure Legends
Supplementary Figure 2 from 1α,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling
Authors: Chen Ping-Tsung , Hsieh Ching-Chuan , Wu Chun-Te , Yen Tzu-Chen , Lin Paul-Yang , Chen Wen-Cheng , Chen Miao-Fen
Published: April 2023

Supplementary Figure 2. Effects of Calcitriol on migration capacity and EMT in vitro
Supplementary Tables 1 and 2 from Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling
Authors: Balic Anamaria , Sørensen Morten Dræby , Trabulo Sara Maria , Sainz Bruno , Cioffi Michele , Vieira Catarina R. , Miranda-Lorenzo Irene , Hidalgo Manuel , Kleeff Joerg , Erkan Mert , Heeschen Christopher
Published: April 2023

PDF - 48K, Table S1. List of utilized primers. Table S2. List of utilized antibodies.
Supplementary Figure Legends from Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells
Authors: Karpel-Massler Georg , Westhoff M.-Andrew , Zhou Shaoxia , Nonnenmacher Lisa , Dwucet Annika , Kast Richard E. , Bachem Max G. , Wirtz Christian R. , Debatin Klaus-Michael , Halatsch Marc-Eric
Published: April 2023

PDF file - 52 KB
Supplementary Figure 5 from Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells
Authors: Karpel-Massler Georg , Westhoff M.-Andrew , Zhou Shaoxia , Nonnenmacher Lisa , Dwucet Annika , Kast Richard E. , Bachem Max G. , Wirtz Christian R. , Debatin Klaus-Michael , Halatsch Marc-Eric
Published: April 2023

PDF file - 46 KB, Densitometric analysis corresponding to the Western blots shown in Fig. 7 and one additional independent set of experiments.
Supplementary Figure 4 from Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells
Authors: Karpel-Massler Georg , Westhoff M.-Andrew , Zhou Shaoxia , Nonnenmacher Lisa , Dwucet Annika , Kast Richard E. , Bachem Max G. , Wirtz Christian R. , Debatin Klaus-Michael , Halatsch Marc-Eric
Published: April 2023

PDF file - 495 KB, The antimigratory effect of the combined treatment with erlotinib (E) and NSC23766 (N) is independent of anti-adhesive effects.
Supplementary Figure 3 from Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells
Authors: Karpel-Massler Georg , Westhoff M.-Andrew , Zhou Shaoxia , Nonnenmacher Lisa , Dwucet Annika , Kast Richard E. , Bachem Max G. , Wirtz Christian R. , Debatin Klaus-Michael , Halatsch Marc-Eric
Published: April 2023

PDF file - 417 KB, Combined treatment with erlotinib (E) and NSC23766 (N) does not enhance the inhibition of cell migration of T98MG cells.
Supplementary Figure 2 from Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells
Authors: Karpel-Massler Georg , Westhoff M.-Andrew , Zhou Shaoxia , Nonnenmacher Lisa , Dwucet Annika , Kast Richard E. , Bachem Max G. , Wirtz Christian R. , Debatin Klaus-Michael , Halatsch Marc-Eric
Published: April 2023

PDF file - 44 KB, Lapatinib and NSC23766 yield a synergistic antiproliferative effect on established and primary cultured glioblastoma cells.
Supplementary Figures 1 and 2 and Supplementary Tables 1 through 3 from A Novel CDK9 Inhibitor Shows Potent Antitumor Efficacy in Preclinical Hematologic Tumor Models
Authors: Yin Tinggui , Lallena Maria J. , Kreklau Emiko L. , Fales Kevin R. , Carballares Santiago , Torrres Raquel , Wishart Graham N. , Ajamie Rose T. , Cronier Damien M. , Iversen Phillip W. , Meier Timothy I. , Foreman Robert T. , Zeckner Douglas , Sissons Sean E. , Halstead Bart W. , Lin Aimee B. , Donoho Gregory P. , Qian Yuewei , Li Shuyu , Wu Song , Aggarwal Amit , Ye Xiang S. , Starling James J. , Gaynor Richard B. , de Dios Alfonso , Du Jian
Published: April 2023

PDF - 1128K, Figure S1. Knockdown of CDK7 and CDK9 can inhibit RNAP II CTD P-Ser2 and P-Ser5. Figure S2. LY2857785 and flavopiridol inhibit MCL-1, XIAP protein expression and induce CASP-3 and cleaved PARP in AML cell MV-4-11. Table S1. LY2857785 inhibits solid tumor cell proliferation and induces apoptosis. Table S2. 261 probsets gene signature in sens and res cell lines. Table S3. LY2857785 inhibits proliferation of normal human hematopoietic cells in vitro.
Supplemental Figure 1 from A Novel Neutralizing Antibody Targeting Pregnancy-Associated Plasma Protein-A Inhibits Ovarian Cancer Growth and Ascites Accumulation in Patient Mouse Tumorgrafts
Authors: Becker Marc A. , Haluska Paul , Bale Laurie K. , Oxvig Claus , Conover Cheryl A.
Published: April 2023

Supplemental Figure 1. Ultrasound is an accurate and precise measurement of actual tumor weight and ascites volume.
Supplementary Figure 2 from Phosphoproteomics of MAPK Inhibition in BRAF-Mutated Cells and a Role for the Lethal Synergism of Dual BRAF and CK2 Inhibition
Authors: Parker Robert , Clifton-Bligh Roderick , Molloy Mark P.
Published: April 2023

PDF file - 66K, Response to combinatorial MAPK1/CK2 inhibition in thyroid cells lines.
Supplementary Figure 1 from Phosphoproteomics of MAPK Inhibition in BRAF-Mutated Cells and a Role for the Lethal Synergism of Dual BRAF and CK2 Inhibition
Authors: Parker Robert , Clifton-Bligh Roderick , Molloy Mark P.
Published: April 2023

PDF file - 251K, Phosphosite analyser output. Heat map of kinase set enrichment analysis (KSEA) using the program phosphosite analyser.
Supplementary Figure 6 from Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro
Authors: Wu Xuping , Sooman Linda , Wickström Malin , Fryknäs Mårten , Dyrager Christine , Lennartsson Johan , Gullbo Joachim
Published: April 2023

PDF file - 73K, Figure S6 The activity of PPP correlated (p<0.05) with that of vinorelbine (A), and docetaxel (B), but not with gemcitabine (C) or cisplatin (D). The correlation was 0.62 for 5-FU (not significant; data not shown).
Supplementary Figures S1-S9 from Strengthening Context-Dependent Anticancer Effects on Non–Small Cell Lung Carcinoma by Inhibition of Both MET and EGFR
Authors: Zhang Yu-Wen , Staal Ben , Essenburg Curt , Lewis Steven , Kaufman Dafna , Vande Woude George F.
Published: April 2023

Supplementary Figures S1-S9 - PDF file 588K, Supplementary Figure S1: The chemical structures of SGX523 and erlotinib; Supplementary Figure S2: The effect of erlotinib on basal tyrosine phosphorylation of EGFR; Supplementary Figure S3: Inhibition of MET, EGFR, and their downstream signaling by SGX523 and erlotinib in the absence of ligands; Supplementary Figure S4: Dose-dependent inhibition of H1373 and H1993 cell proliferation by SGX523 and/or erlotinib in vitro; Supplementary Figure S5: SGX523 and erlotinib combination results in a stronger ERK inhibition in the H1373 tumors; Supplementary Figure S6: The effects of SGX523 and/or erlotinib on cell viability of H358, H1373, H1993 and EBC-1; Supplementary Figure S7: EBC1-Sg3-H62 and EBC1-Sg3-H71 cells are relatively less sensitive to SGX523, compared to the parental EBC-1 cells; Supplementary Figure S8: The effect of SGX523 and/or erlotinib on MET and EGFR in the EBC-1 and its tumor derivatives; Supplementary Figure S9. Kaplan-Meier survival analyses of the mice in the drug studies
Supplementary Figure 2 from Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro
Authors: Wu Xuping , Sooman Linda , Wickström Malin , Fryknäs Mårten , Dyrager Christine , Lennartsson Johan , Gullbo Joachim
Published: April 2023

PDF file - 28K, Figure S2 Analysis of potential correlations between PPP activity and the expression (A) or phosphorylation (B) of IGF-1R in nine ESCC cell lines. No significant correlation was identified in either case (p>0.05).
Data Supplement from Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na
Authors: Mäki-Jouppila Jenni H.E. , Laine Leena J. , Rehnberg Jonathan , Narvi Elli , Tiikkainen Pekka , Hukasova Elvira , Halonen Pasi , Lindqvist Arne , Kallio Lila , Poso Antti , Kallio Marko J.
Published: April 2023

Supplemental Movie 1. Cent-1 treated HeLa H2B-GFP mCherry-tubulin cells arrest in mitosis for several hours with misaligned chromosomes, followed by cell death or abnormal exit from M phase. The cell on the left hand side forms a multipolar spindle after nuclear envelope breakdown (NEB) and exhibits a long mitotic arrest followed by cell division into three daughter cells (NEB to anaphase time is 5 h 15 min). The cell on the right hand side initially forms a tri-foci spindle (time point 01:15), then two microtubule emanating foci fuse together (time point 01:35) to form a bipolar spindle. The cell exhibits a long mitotic arrest followed by cell death (NEB to cell death time is 10 h 30 min). During the arrest most chromosomes congress to the metaphase plate but some remain misaligned near the spindle poles. The cells were treated with 5 microM Cent-1 for 1 h before time-lapse filming started with 5 min frame capture interval. The numbers indicate time in h:min. H2B-GFP is coloured red and mCherry tubulin green.
Data Supplement from Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na
Authors: Mäki-Jouppila Jenni H.E. , Laine Leena J. , Rehnberg Jonathan , Narvi Elli , Tiikkainen Pekka , Hukasova Elvira , Halonen Pasi , Lindqvist Arne , Kallio Lila , Poso Antti , Kallio Marko J.
Published: April 2023

Supplemental Movie 3. Cent-1 treatment decreases microtubule dynamicity in human lung carcinoma A549 cells. A549 cells stably expressing EGFP-alpha-tubulin were treated with 5 microM Cent-1 for 1 h before the analysis of microtubule dynamicity using 10 s frame capture interval for a total of 4 min. For the analysis, microtubule plus-ends were marked (blue dots) and the total growth and shrinkage velocities of individual microtubules were measured.
Supplementary Figures 1 through 3 and Supplementary Tables 1 through 3 from OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice
Authors: Iusuf Dilek , Ludwig Marion , Elbatsh Ahmed , van Esch Anita , van de Steeg Evita , Wagenaar Els , van der Valk Martin , Lin Fan , van Tellingen Olaf , Schinkel Alfred H.
Published: April 2023

PDF - 278KB, Supplemental figure 1. pH equilibrium between the lactone (closed ring) form and free carboxylic acid (open) form of irinotecan and SN-38. Supplemental Figure 2. Role of Oatp1a/1b uptake transporters in small intestinal (tissue plus content) exposure of irinotecan and SN-38 after intravenous administration of irinotecan (10 mg/kg) to female wild-type and Oatp1a/1b knockout mice. Supplemental Figure 3. Role of Oatp1a/1b uptake transporters in kidney exposure of irinotecan and SN-38 after intravenous administration of irinotecan (10 mg/kg) to female wild-type and Oatp1a/1b knockout mice. Supplemental Table 1. Overview of ΔCt values of the RT-PCR analysis of expression of several esterases in liver of female wild-type, Oatp1a/1b knockout (Slco1a/1b(-/-)) and OATP1B1/1B3 humanized mice. Supplemental Table 2. Overview of ΔCt values of the RT-PCR analysis of expression of several esterases in small intestine of female wild-type, Oatp1a/1b knockout (Slco1a/1b(-/-)) and OATP1B1/1B3 humanized mice. Supplemental Table 3. Overview of ΔCt values of the RT-PCR analysis of expression of several esterases in kidney of female wild-type, Oatp1a/1b knockout (Slco1a/1b(-/-)) and OATP1B1/1B3 humanized mice.
Data Supplement from Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na
Authors: Mäki-Jouppila Jenni H.E. , Laine Leena J. , Rehnberg Jonathan , Narvi Elli , Tiikkainen Pekka , Hukasova Elvira , Halonen Pasi , Lindqvist Arne , Kallio Lila , Poso Antti , Kallio Marko J.
Published: April 2023

Supplemental Movie 4. Rigosertib treatment decreases microtubule dynamicity in human lung carcinoma A549 cells. A549 cells stably expressing EGFP-alpha-tubulin were treated with 50 nM rigosertib for 1 h before the analysis of microtubule dynamicity using 10 s frame capture interval for a total of 4 min. For the analysis, microtubule plus-ends were marked (blue dots) and the total growth and shrinkage velocities of individual microtubules were measured.
Supplementary File 1 from A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance
Authors: Xia Junfeng , Jia Peilin , Hutchinson Katherine E. , Dahlman Kimberly B. , Johnson Douglas , Sosman Jeffrey , Pao William , Zhao Zhongming
Published: April 2023

XLSX - 17K, Supplementary File S1. 632 melanoma candidate genes.
Supplementary Figures 1 through 16 from A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance
Authors: Xia Junfeng , Jia Peilin , Hutchinson Katherine E. , Dahlman Kimberly B. , Johnson Douglas , Sosman Jeffrey , Pao William , Zhao Zhongming
Published: April 2023

PDF - 912K, Supplementary Figure S1. NRAS mutations in the 69 pan-negative melanoma samples. Supplementary Figure S2. KIT mutations in the 69 pan-negative melanoma samples. Supplementary Figure S3. GNAQ mutations in the 69 pan-negative melanoma samples.Supplementary Figure S4. GNA11 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S5. RAC1 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S6. ADAMTS18 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S7. EPHA7 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S8. TAF1L mutations in the 69 pan-negative melanoma samples. Supplementary Figure S9. NF1 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S10. ALK mutations in the 69 pan-negative melanoma samples. Supplementary Figure S11. STK31 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S12. DGKI mutations in the 69 pan-negative melanoma samples. Supplementary Figure S13. EPHA4 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S14. ERBB4 mutations in the 69 pan-negative melanoma samples. Supplementary Figure S15. SYK mutations in the 69 pan-negative melanoma samples. Supplementary Figure S16. KDR mutations in the 69 pan-negative melanoma samples.
Supplementary Figure 2 from Downregulation of Hepatoma-Derived Growth Factor Contributes to Retarded Lung Metastasis via Inhibition of Epithelial–Mesenchymal Transition by Systemic POMC Gene Delivery in Melanoma
Authors: Tsai Han-En , Liu Guei-Sheung , Kung Mei-Lang , Liu Li-Feng , Wu Jian-Ching , Tang Chia-Hua , Huang Ching-Hui , Chen San-Cher , Lam Hing-Chung , Wu Chieh-Shan , Tai Ming-Hong
Published: April 2023

PDF file - 1470K, Supplementary Figure 2. Evaluation of the Luc-B16-F10 cells delivery efficiency in vivo. Bioluminescence live images of day 0, day 7 and day 14 provided an estimation of the number of metastatic cells upon injection.
Supplementary Figure 2 from Novel Curcumin-Loaded Magnetic Nanoparticles for Pancreatic Cancer Treatment
Authors: Yallapu Murali M. , Ebeling Mara C. , Khan Sheema , Sundram Vasudha , Chauhan Neeraj , Gupta Brij K. , Puumala Susan E. , Jaggi Meena , Chauhan Subhash C.
Published: April 2023

PDF file - 153K, Figure S2. Serum proteins adsorption of MNP-CUR formulation.
Supplementary Figure 1 from Downregulation of Hepatoma-Derived Growth Factor Contributes to Retarded Lung Metastasis via Inhibition of Epithelial–Mesenchymal Transition by Systemic POMC Gene Delivery in Melanoma
Authors: Tsai Han-En , Liu Guei-Sheung , Kung Mei-Lang , Liu Li-Feng , Wu Jian-Ching , Tang Chia-Hua , Huang Ching-Hui , Chen San-Cher , Lam Hing-Chung , Wu Chieh-Shan , Tai Ming-Hong
Published: April 2023

PDF file - 265K, Supplementary Figure 1. Experimental scheme of metastatic melanoma in C57BL/6 mice.
Supplementary Figures 1 - 3 from Combined Targeting of mTOR and AKT Is an Effective Strategy for Basal-like Breast Cancer in Patient-Derived Xenograft Models
Authors: Xu Siguang , Li Shunqiang , Guo Zhanfang , Luo Jingqin , Ellis Matthew J. , Ma Cynthia X.
Published: April 2023

PDF file - 129K, Supplementary Fig. 1 Interaction Plot of MK-2206 and MK-8669 on tumor growth inhibition in WU-BC4 (a) and WU-BC5 (b) Supplementary Fig. 2 Interaction Plot of MK-2206 and MK-8669 on tumor cell Ki67 in WU-BC4 (a) and WU-BC5 (b) Supplementary Fig. 3 Interaction Plot of MK-2206 and MK-8669 on tumor growth inhibition in WU-BC3 (shPTEN) (a) and WU-BC3 (shGFP) (b).
Supplementary Figure Legends from Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF-β, and Wnt Signaling Pathways
Authors: Basu Dipanjan , Lettan Robert , Damodaran Krishnan , Strellec Susan , Reyes-Mugica Miguel , Rebbaa Abdelhadi
Published: April 2023

PDF - 62K, Legends for Supplementary Figures.
Supplementary Table 1 from Expression of the miR200 Family of microRNAs in Mesothelial Cells Suppresses the Dissemination of Ovarian Cancer Cells
Authors: Sugiyama Kazuya , Kajiyama Hiroaki , Shibata Kiyosumi , Yuan Hong , Kikkawa Fumitaka , Senga Takeshi
Published: April 2023

PDF - 11K, Sequence of primers used in the study. Red fonts indicate mutated nucleotides.
Supplementary Figure 6 from Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF-β, and Wnt Signaling Pathways
Authors: Basu Dipanjan , Lettan Robert , Damodaran Krishnan , Strellec Susan , Reyes-Mugica Miguel , Rebbaa Abdelhadi
Published: April 2023

PDF - 57K, Respective contributions of AMPK and Lats1 in mediating the action of C19.
Supplementary Figure 3 from Expression of the miR200 Family of microRNAs in Mesothelial Cells Suppresses the Dissemination of Ovarian Cancer Cells
Authors: Sugiyama Kazuya , Kajiyama Hiroaki , Shibata Kiyosumi , Yuan Hong , Kikkawa Fumitaka , Senga Takeshi
Published: April 2023

PDf - 67K, Mice were intraperitoneally injected with rAD-Ctrl or rAD-miR-200 and two days later, ES-2 cells were implanted. Three days later, mice were sacrificed and mesenterium was fixed and stained with anti-FN1 antibody and DAPI.