bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenic BCS1L Mutation Resulting in Hypertrophic Cardiomyopathy: A Unique Presentation of Nuclear Mitochondrial Disease
Authors: Incognito Cameron , Hedley Jeffrey , Posadas Kristine T. , Wang Xiangling , Desai Milind
Published: March 2023

A 21-year-old man with sensorineural hearing loss and glaucoma presented with severely limited exercise capacity since childhood. He was found to have biventricular concentric hypertrophy with greatest wall thickening at the posterior and lateral walls of the left ventricle apex (1.7 cm) and the free wall of the right ventricle (1.1 cm). There was no inducible left ventricular outflow tract obstruction. Metabolic testing revealed marked lactic aciduria (1,650.1 μmol/mmol creatinine) and plasma lactate (3.9 mmol/L). A sarcomeric hypertrophic cardiomyopathy gene panel was unremarkable, but mitochondrial gene analysis revealed a homozygous c.385G>A (p.Gly129Arg) pathogenic mutation in the BCS1L gene. This gene is responsible for an assembly subunit of cytochrome complex III in the respiratory transport chain and is the rarest respiratory chain defect. This gene has not frequently been implicated in cardiomyopathy. Mitochondrial hypertrophic cardiomyopathy is more rare than hypertrophic cardiomyopathy resulting from sarcomeric mutations and is more likely to be symmetric, less frequently results in left ventricular outflow tract obstruction, and is more likely to progress to dilated cardiomyopathy. Evidence-based screening protocols have not been established; treatment follows guideline-directed medical therapy for congestive heart failure, including evaluation for heart transplantation. This report expands the phenotype of the BCS1L mutation and suggests that affected patients may need screening for underlying cardiomyopathy.
Antioxidant, Cytotoxic, and Insulinotropic Activities of Several Leaves Extracts of Medicinal Plants
Authors: Marzanti Amelia , Aprianti Riska Widya , Mariya Silmi , Noviana Rachmitasari , Rohaeti Eti , Suparto Irma Herawati
Published: March 2023

The prevalence of diabetes mellitus and cancer is increasing; thus, research into efficient treatments utilizing active compounds derived from medicinal plants has focused on these diseases. Through the agro maritime 4.0 approach, medicinal plants are explored in the archipelago of Indonesia, particularly on Tinjil Island, Banten Province. The medicinal plants identified on the island include Morinda citrifolia, Terminalia catappa, and Gnetum gnemon. Therefore, this study aimed to evaluate the in vitro of aqueous extracts of leaves of those three plant species. All aqueous extracts were analyzed for total phenolic content and further tested for antioxidant activity using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), MTT cytotoxic activity (3-[4,5-dimethylthiazole-2-yl]-2- 5-diphenyl-tetrazolium-bromide) in MCF-7- (ATCC HTB 22) and Burkitt’s Lymphoma Raji (ATCC CCL 86) cells, and insulinotropic activity in pancreatic BRIN BD11 cells. The results showed that the total phenolic content of T. catappa was significantly higher (9.21 ± 2.49 mg GAE/g extract sample) compared to M. citrifolia (3.00 ± 0.35 mg GAE/g) and G. gnemon (7.47 ± 0.33 mg GAE/g). Compared to the other two extracts, T. catappa extract has the best DPPH antioxidant activity of IC50 7.44 ± 0.77 µg/mL (p<0.05). MTT cytotoxic activity in all samples did not inhibit the proliferation of Raji cells but did the proliferation of MCF-7 cells. The IC50 for the best cytotoxic activity was shown in M. citrifolia (8.06 µg/mL). T. catappa triggered insulin secretion at 62.5 µg/mL with the highest insulin concentration (54.55 mg/mL). The aqueous extract of T. catappa leaves shows potential as an antioxidant and insulinotropic agent, while M. citrifolia leaves have a cytotoxic effect with anticancer potential.
KOBİ’lerde yeşil süreç inovasyonunu teşvik etmek için yeşil dönüşümcü liderliğin ve yeşil temel yeteneklerin etkilerinin incelenmesi
Authors: ÖZGÜL Burcu
Published: March 2023

Bu araştırmanın amacı, küçük ve orta ölçekli işletmelerdeki (KOBİ) işletme sahibi yöneticilerin yeşil dönüşümcü liderliğinin yeşil süreç inovasyonu üzerindeki rolünü incelemektir. Daha spesifik olarak, doğal kaynak temelli teori ve üst kademeler teorisini bir araya getiren bu çalışma, yeşil temel yeteneği, yeşil dönüşümcü liderliğin yeşil süreç inovasyonunu harekete geçirdiği önemli bir temel aracılık mekanizması olarak görmektedir. Geliştirilen teorik modeli test etmek için 403 KOBİ’den veri toplanmıştır. Analizi gerçekleştirmek için Smart PLS 3 analiz programı kullanılmıştır. Sonuçlar, KOBİ’lerdeki işletme sahibi yöneticilerin yeşil dönüşümcü liderliğinin yeşil süreç inovasyonu ile doğrudan ve yeşil temel yetenekler aracılığıyla dolaylı pozitif bir ilişkisi olduğunu doğrulamaktadır. Ayrıca sonuçlar, KOBİ’lerdeki işletme sahibi yöneticilerin yeşil dönüşümcü liderliğinin yeşil temel yetenekler üzerinde olumlu bir etkisi olduğunu ve yeşil temel yeteneklerin de yeşil süreç inovasyonu desteklediğini göstermektedir. Çalışma, yeşil dönüşümcü liderlik ile yeşil süreç inovasyonu arasındaki ilişkileri aydınlatmakta, özellikle imalat KOBİ'leri endüstrisinde yeşil süreç inovasyonunu etkileyebilecek yönetsel gelişim alanlarının altını çizerek teorik ve pratik bilgilere katkıda bulunmaktadır.
Oxidative stress in thyroid dysfunction
Authors: Eddib Intissar , Barhoumi Lassaad , Mahmoudi Ahmed , Ben Nasr Hmed
Published: March 2023

Thyroidal dysfunction is a risk factor for the development of many metabolic disorders and pathologies. In this work we evaluated the status of the oxidative stress in hypo- and hyperthyroidism, as a sign for developing associated diseases. A total of 44 participants have been recruited and distributed into three groups: Euthyroidism (6), Hypothyroidism (29) and hyperthyroidism (9). Their hematological and biochemical parameters were diagnosed. Free thyroxin 4 (FT4) and thyroid stimulating hormone (TSH) were determined using Elisa kits. Malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were measured in plasma samples by spectrophotometric methods. Our results showed an increase in lipid peroxidation in both hypo- and hyperthyroidism (1.14 ±0.631 µmol. L-1 and 0.904 ±0.179 µmol. L-1 , respectively) in comparison to normal cases (0.821 ±0.173 µmol.L-1 ). Our findings highlight the misbalance of the oxidative stress occurrence in hypo- and hyper-thyroidism due to the subsequent metabolic rate disturbances.
Magical ayurvedic spices and herbs that can boost our immunity
Authors: Singh Sunita
Published: March 2023

Today world is facing an unprecedented pandemic COVID 19 caused by SARS COV 2. In present scenario it’s become more important to build our defense system more strong against it as no evidence-based treatment for COVID-19 is developed yet. Since time immemorial, traditional spices and herbs have played a vital role as immuno-boosters in Indian cuisine. Herbs and spices were well known from ancient times for their medicinal properties. More than 80 spices are grown in different parts of the world, particularly in Asia. India is home to several spices that are used extensively in traditional medicine. Spices like turmeric, saffron, cloves, cinnamon, carom seeds, ginger and garlic are known to have a plethora of beneficial properties. Herbs like mint, tulsi (Holy Basil), leaves of neem, ashwagandha, giloy are said to have several health benefits. Herbs and spices are wonderful because, unlike drugs, we don’t need to “take” them. Instead, we can add them to our favorite dishes for a kick of flavor and increased immunity.
Comment enseigner la grammaire slovaque?
Authors: JAMBOROVA LEMAY Diana
Published: March 2023

Dans notre article, nous aborderons la problématique liée à l’enseignement de la grammaire théorique slovaque aux francophones dans le milieu universitaire. Tout comme dans notre vie de tous les jours, les nouvelles technologies s’imposent de plus en plus dans notre pratique de l’enseignement à l’université. Nous collaborons depuis plusieurs années avec les collègues belges de l’Université de Hasselt qui ont élaboré la plateforme d’enseignement à distance EMCG.
Tarih ve Kolektif Bellek Aktarımında Sanal Gerçeklik: “War Remains” Örneği
Authors: YEGEN Ceren , DÖNMEZ Servet Can
Published: March 2023

Kolektif bellek, ortaklıklar üzerinden hareket ederek kolektif değerlerin oluşması gibi pekiştirilmesini de amaçlar. Canlandırma sanatı olarak diorama dolaylı eserlerde de ortak anlatı ve değerler açıkça görülmekte, kolektif bilinç inşası amaçlanmaktadır. Örneğin Türkiye’de yer alan bazı beyaz propaganda mekanizmaları üzerinden Türk ulusunun dostluk, ulusal mücadele ve fedakârlık anlayışı sıcak tutulmaya çalışılmaktadır. Ancak çağımızda anlatının yapısı da değişmiştir. Günümüzde dijital anlatılar da bir tarih ve kolektif bellek aktarıcısı görevi görmektedir. Örneğin sanal gerçeklik gibi dijital teknolojiler, özellikle genç nesle yönelik kurgulanan bilgisayar oyunlarıyla anlatı ve kolektif birçok unsuru etkili ve etkileşimli şekilde işlemektedir. Bu nedenle bu çalışmada, tarih ve kolektif bellek aktarımında dijital anlatının mevcut rolü tartışılmıştır. Bu amaç doğrultusunda savaş meydanında olmanın nasıl hissettirdiğini anlamaya odaklı olan ve 31 Temmuz 1917 – 10 Kasım 1917 tarihleri arasında gerçekleşen Büyük Passchendaele Muharebesi’nden (I. Dünya Savaşı sırasında) bazı çatışma anlarını deneyimleme imkânı sunan “War Remains: Dan Carlin Presents an Immersive Memory” adlı sanal gerçeklik içeriği, Ümmühan Molo’nun “360 Derece VR Film Çözümleme Modeli” üzerinden analiz edilmiştir. Belirli bir taraftan veya cepheden verilmeyen hikâyede, savaş ortamının deneyimlenmesine olabildiğince tarafsız olarak odaklanıldığı görülmüştür.
Mersin İlindeki (Türkiye) Bazı Doğal ve Kültürel Sit Alanlarının Floristik Yapısı Üzerine Bir Çalışma
Authors: TEL Ahmet Zafer , ORTAÇ İshak , İLÇİM Ahmet , ÖZUSLU Ergün
Published: March 2023

Bu çalışmada Mersin ili sınırları içerisinde bulunan, doğal ve kültürel sit özelliği taşıyan Aphrodisias Sit Alanı ve Tisan Mevkii, Taşucu Kalesi ve Boğsak Adası, Eğribük Koyu ve Dana Adası, Gilindere Mağarası, Aydıncık Adaları ve Beşparmak Adaları’nın florası üzerine bir envanter çalışması yapmak ve Mersin ilinin floristik ve biyolojik çeşitlilik araştırmalarına katkı sağlamak amaçlanmıştır. Mersin ili sınırlarındaki adalarda daha önce doğrudan flora tespitine yönelik çalışma yapılmamıştır. Araştırma alanları olan Mersin iline ait dört farklı bölgede toplam 26 familya ve 57 cinse ait 66 farklı takson tespit edilmiştir. Tespit edilen taksonların fitocoğrafik bölgelere göre dağılımı şöyledir: Akdeniz (Doğu Akdeniz dahil) 37 takson (%56.07), Geniş yayılışlı 11 takson (%16.66) ve bilinmeyen 18 (%27.27) taksondur. Avrupa - Sibirya ve İran - Turan coğrafik bölge elementi bulunmamaktadır. Araştırma alanında toplam 1 endemik ve 1 nadir bitki taksonu tespit edilmiştir.
Vamos brincar em casa? Orientações a comunidade sobre formas de estimular bebês no primeiro ano de vida
Authors: Trindade Jorge Luiz de Andrade , Oliveira Gabrielli  Dos Santos Bitencourt
Published: March 2023

Objetivo: Descrever a vivência de acadêmicos do curso de Fisioterapia na orientação de usuários de uma unidade de saúde da família sobre formas de estimular bebês no primeiro ano de vida através do brincar no cuidado da saúde e bem-estar deles e de suas famílias. Métodos: Trata-se de relato da experiência, na construção de conhecimento de uma comunidade sobre a estimulação do desenvolvimento neuropsicomotor (DNPM) através do brincar e brincadeiras no primeiro ano de vida, considerando as fases do desenvolvimento infantil. Foi desenvolvida no componente curricular Prática Integral da Saúde de Crianças e Adolescentes, do Curso de Fisioterapia da Universidade FEEVALE, em uma Unidade de Saúde em Novo Hamburgo, Rio Grande do Sul. Resultados: Nas quartas-feiras a tarde, durante o segundo semestre de 2021, um grupo de acadêmicos promoviam rodas de conversa em sala de espera de unidade de saúde com os usuários, conversando sobre formas lúdicas de estimulação neuropsicomotora do bebê no primeiro ano de vida, através do brincar. Para tanto, foi utilizado uma cartilha com os marcos do DNPM na infância e formas de estimulação através de brincadeiras. Considerações Finais: Com esta experiência, os acadêmicos puderam ter contato com a comunidade e conversar com usuários na Atenção Básica em Saúde, sobre as orientações elaboradas e sugerir formas adequadas de cuidado na infância. Contextualizaram também, conhecimentos teóricos na prática humanizada de intervenção junto aos usuários na Atenção Básica em Saúde.
COVID-19 e a assistência multiprofissional às pessoas com síndrome gripal: relato de experiência de Residentes Multiprofissionais em Atenção Básica
Authors: Silva Júnior José Antonio da , Dantas Maiara Bezerra , Santos Marcus Vinicius Dutra dos , Medeiros Mikaele Garcia de , Fonseca Álvaro Micael Duarte , Nascimento Ellany Gurgel Cosme do
Published: March 2023

Objetivo: descrever as experiências vivenciadas pelos residentes do Programa de Residência em Atenção Básica da Escola Multicampi de Ciências Médicas da Universidade Federal do Rio Grande do Norte, no decorrer do período de enfrentamento à pandemia, em um Centro de Referência para COVID-19. Métodos: trata-se de um relato de experiência, descritivo com abordagem qualitativa, baseado na atuação e em ações realizadas pelos residentes, entre os meses de maio a julho de 2021, no município de Caicó, no Rio Grande do Norte. Resultados: durante esse período, os residentes atuaram na realização de testes por RT-PCR, testes rápidos e sorologias, além da detecção e acompanhamento dos casos suspeitos/confirmados da doença e, além disso, informações, consultas e resultados expressos. Considerações finais: essa experiência proporcionou aos residentes a socialização do conhecimento apreendido nesse cenário da pandemia da COVID-19, como agentes propagadores de informações, além de possibilitar a atuação dos residentes tanto na assistência direta quanto no gerenciamento das atividades do serviço de saúde em questão.
Covid-19 não é democrática: determinação social do processo saúde-doença numa análise de gênero-raça-classe-sexualidade
Authors: Vinicius Ribeiro Cruz Marcus , Clara Santana Silveira Maria , Julie Soares Resende Nathália , De Paula Gomes Sthefany
Published: March 2023

A disseminação da COVID-19 no Brasil se estabeleceu em um cenário político de importantes retrocessos democráticos e de desmonte da seguridade social. A fim de investigar mais profundamente esse contexto, o campo da saúde possui, historicamente, formulações de modelos teóricos que buscam as compreensões de saúde e doença. Ademais, para explicar as condições de saúde da população através de uma noção mais completa, torna-se fundamental debater sobre o processo de saúde-doença e sua determinação social em uma episteme de gênero-raça-classe-sexualidade, visto que a saúde entendida como amplo desenvolvimento das potencialidades humanas em certo momento histórico, choca-se com as limitações estabelecidas pela estrutura para o alcance dessas capacidades através das desigualdades que marcam a realidade nacional. Os desdobramentos cotidianos e os impactos diretos na vida da população negra, nas mulheres, na população LGBTQIA+ e, de forma geral, na classe trabalhadora  na pandemia, com maior número de mortes, afetando em maior grau a saúde mental, as relações de trabalho e familiares, validam de forma concreta a determinação social do processo de saúde-doença. Portanto, o projeto e concepção de saúde precisa se posicionar na disputa de percepção crítica da realidade, e de ação para construir  uma sociedade emancipada.
El diario de un limeño que murió en la Primera Guerra Mundial
Authors: Bonfiglio Giovanni
Published: March 2023

Este ensayo presenta parte de los resultados de un estudio en curso acerca de la migración europea en Perú en la primera mitad del siglo XX. El objetivo es analizar la transformación del grueso de los inmigrantes y mostrar cómo se asimilaron a la sociedad peruana, al punto de llegar a considerarse parte de ella y tomar distancia frente a sus países de origen. Ese sería uno de los efectos de la Primera Guerra Mundial en el Perú.
Entre la psicología y la filosofía de William James : emociones y creencias
Authors: García Laura Inés
Published: March 2023

William James ha sido un pensador destacado de su siglo, tanto por sus aportes en psicología como por su obra filosófica. Sin embargo, resulta poco frecuente encontrar estudios que tracen puentes de comunicación entre los desarrollos del autor en ambas disciplinas, pues algunos de ellos están centrados en sus aportes a la psicología experimental y otros en su filosofía pragmatista. En este trabajo, nuestro objetivo general es mostrar cuál podría ser una de las posibles líneas de conexión entre la psicología y la filosofía de James. Por ello nos proponemos, en particular, abordar una de las áreas que creemos pueden servir como punto de contacto entre estas disciplinas, a saber, la concepción sobre la mente humana que ha formulado este autor.
El giro pragmático en las teorías deliberativas
Authors: Mougán Rivero Juan Carlos
Published: March 2023

El significado del pragmatismo en la teoría política goza de tan amplia variedad de interpretaciones como en el ámbito epistemológico. Una de las líneas más fecundas es la que acentúa el vínculo que dicha inspiración filosófica tiene con las concepciones deliberativas de la democracia. Frente a quienes, como Posner1 (2003) y en diferente modo también Rorty (1991), han insistido en que la inspiración pragmatista supone el abandono de la pretensiones epistémicas de la democracia, autores como Misak (2000) y Talisse (2005 y 2007) se han basado en la obra de Peirce para ofrecer una defensa epistémica de la democracia bajo la convicción de que esta guarda relación con la manera en que defendemos y justificamos nuestras creencias. De acuerdo con ello, lo que proponen es una nueva manera de vincular la democracia con nuestras formas de conocimiento que tienen mayores garantías de veracidad y razonabilidad. La consecuencia de su perspectiva es la defensa de una concepción deliberativa de la democracia en la que lo relevante para la mejora de la calidad de esta forma de gobierno radica en un cierto perfeccionismo epistémico en el desarrollo de las capacidades argumentativas y deliberativas de la ciudadanía (Talisse, 2005, pp. 118-121; 2007, pp. 85-98).
Rorty and Dewey on philosophy and democracy : toward a fruitful conversation
Authors: Voparil Christopher J.
Published: March 2023

En sus primeros ensayos publicados a principios de la década de 1960, Richard Rorty estaba preocupado, no muy diferente de William James, por «el espectáculo de filósofos discutiendo sin cesar sobre los mismos temas». Se embarcó en una búsqueda de caminos de «conversación fructífera», como él la llamó, que finalmente lo llevó al pragmatismo (1967, p. 1; ver también 1961, 1962)1. Este artículo retoma las contribuciones respectivas de Rorty y John Dewey al tema de la filosofía y la democracia en este espíritu de conversación fructífera y tiene dos objetivos principales. El primero es ofrecer una lectura del trabajo de Rorty durante la última década de su vida, particularmente los ensayos recopilados en su último volumen de artículos filosóficos, Philosophy as Cultural Politics (2007), para apoyar la afirmación de que la adopción de Rorty de la idea de la filosofía como política cultural marca una afirmación explícita de las ideas deweyanas. El segundo es examinar el terreno compartido, así como las divergencias, entre estos dos pensadores que surgen como resultado de esta lectura, con miras a promover la contribución del pragmatismo a la democracia y las cuestiones sociales y morales de nuestro tiempo.
John Dewey and the importance of the "qualitative" for democracy
Authors: Pappas Gregorio Fernando
Published: March 2023

A pesar de que Dewey escribió sobre la importancia de lo «cualitativo» (es decir, lo que es no cognitivo, no lingüístico y se ha asociado con los «sentimientos»), solo unos pocos estudiosos de Dewey han enfatizado o han seguir reconstruyendo este aspecto de su filosofía1. Esto es desconcertante, especialmente cuando hay un creciente cuerpo de investigación en psicología social y ciencias cognitivas que respalda la visión de Dewey del pensamiento como cualitativo (ver Green & Haidt, 2002; Haidt, 2001 y Varela, 1999). Mi preocupación aquí, sin embargo, no es reflexionar críticamente sobre los motivos por los que los deweyanos han sido conservadores en este tema, sino proporcionar un argumento positivo de por qué los deweyanos (y los pragmáticos en general) deben, más que nunca, abrazar y continuar investigando sobre el «cualitativo» en la experiencia. Argumentaré que si te importa la democracia, y la mayoría de los deweyanos lo hacen o se supone que lo hacen, entonces debes preguntarte sobre la función de lo cualitativo en la democracia. Dewey argumentó que la democracia era una tarea interminable. Sugeriré algunas tareas positivas y prometedoras para nosotros (los deweyanos) a medida que reconstruimos su filosofía para el siglo XXI. La mala calidad del discurso público en Estados Unidos nos obliga a ampliar la lógica de Dewey para incluir y elaborar las ideas que nos dejó sobre el papel inevitable de lo cualitativo en el pensamiento. Hace falta una investigación más interdisciplinar, abrazadora de la «revolución afectiva» en las ciencias, pero crítica con el dualismo de razonamiento y sentimiento. Sugeriré algunas tareas positivas y prometedoras para nosotros (los deweyanos) a medida que reconstruimos su filosofía para el siglo XXI. La mala calidad del discurso público en Estados Unidos nos obliga a ampliar la lógica de Dewey para incluir y elaborar las ideas que nos dejó sobre el papel inevitable de lo cualitativo en el pensamiento. Hace falta una investigación más interdisciplinar, abrazadora de la «revolución afectiva» en las ciencias, pero crítica con el dualismo de razonamiento y sentimiento. Sugeriré algunas tareas positivas y prometedoras para nosotros (los deweyanos) a medida que reconstruimos su filosofía para el siglo XXI. La mala calidad del discurso público en Estados Unidos nos obliga a ampliar la lógica de Dewey para incluir y elaborar las ideas que nos dejó sobre el papel inevitable de lo cualitativo en el pensamiento. Hace falta una investigación más interdisciplinar, abrazadora de la «revolución afectiva» en las ciencias, pero crítica con el dualismo de razonamiento y sentimiento.
La relevancia de "el concepto de arco reflejo en psicología" en la filosofía contemporánea de las ciencias cognitivas
Authors: Venturelli Nicolás
Published: March 2023

El trabajo se desarrolla siguiendo los siguientes puntos. Tras una breve presentación general del enfoque dinamicista dentro de la ciencia cognitiva corporizada y de su impacto en el campo, doy razones para justificar cierta continuidad entre el movimiento corporizado y la filosofía pragmatista de Dewey, tomada en su conjunto. A continuación, paso al análisis pormenorizado de las ideas centrales del artículo de Dewey, tras algunas precisiones en torno de su interpretación: divido mis consideraciones entre los aportes críticos y los aportes positivos que pueden desprenderse del artículo y que pueden justificadamente reconducirse hasta el enfoque dinamicista en las ciencias cognitivas.
Leyendas y cuentos malgaches : su relevancia en la educación
Authors: Linaza Iglesias José Luis
Published: March 2023

Este primer informe sobre la importancia de leyendas y cuentos en la educación infantil es fruto de una investigación realizada en los primeros años del siglo XXI, en la que José Luis Linaza tuvo la oportunidad de visitar y recorrer varios lugares de Madagascar, así como visitar y utilizar alguna de las entonces escasas bibliotecas públicas.
Efecto de los mecanismos participativos escolares en el desarrollo de actitudes favorables hacia la democracia y la libertad política : el caso de estudiantes peruanos recientemente egresados del nivel secundario
Authors: Stojnic Lars
Published: March 2023

En el presente trabajo analizaré, partiendo del análisis del enfoque de desarrollo humano, el rol que cumpliría la escuela peruana en el fomento de la libertad de los individuos a participar de la vida pública y de la constitución de la democracia. Concretamente, propongo discutir si es que la existencia de mecanismos de participación estudiantil al interior de las escuelas tendría algún efecto en la disposición de las y los estudiantes peruanos hacia la democracia como forma de gobierno y hacia la libertad política.
Reconocimiento y memoria en el siglo XIX : los campesinos republicanos de Ayacucho
Authors: Pereyra Chávez Nelson Ernesto
Published: March 2023

Este artículo intenta comprender cómo los campesinos de Ayacucho participaron en la formación del Estado republicano en el siglo XIX. Por ello, estudia, primero, las demandas y estrategias campesinas de reconocimiento para con el Estado republicano en formación. En segundo lugar, se elabora un trabajo de memoria de los campesinos. Argumenta que la memoria es usada por estos pobladores como una conciencia subjetiva de un pasado vivo y presente que emerge en una coyuntura particular frente a punto de referencia social (el «marco social de la memoria») y se expresa en una narrativa que puede condensar diversos recuerdos particulares (Stern, 2009, p. 31).
Hoy o nunca : la celebración de la batalla de Sángrar y la reivindicación de memorias locales en Canta
Authors: Hurtado Lourdes
Published: March 2023

Este artículo explora la construcción de una memoria local alrededor de la celebración de la batalla o combate de Sángrar en la provincia de Canta, Lima. Es una reflexión inicial sobre las conmemoraciones en torno a la batalla: a qué actores les pertenece esa memoria, quiénes tienen la legitimidad para recrearla, y cómo la oficialización de la celebración de un episodio muy poco conocido de la Guerra del Pacífico puede inscribirse en un proceso mayor de reivindicación provinciana ante un Estado que no ha prestado la debida atención a las poblaciones de las zonas rurales y en particular a aquellas de la sierra de Lima. Detrás de la recreación de la memoria sobre la batalla de Sángrar se encuentran los deseos de incorporación y pertenencia de una comunidad provinciana bastante heterogénea que ve con preocupación la falta de reconocimiento estatal sobre su participación histórica en la guerra con Chile y que observa con incertidumbre el futuro de sus generaciones más jóvenes, que no encuentran mayores posibilidades educativas y económicas al terminar la secundaria, y por ello, tarde o temprano, terminan migrando a Lima.
El quipu que los indios de Parinacocha presentaron al licenciado Polo
Authors: Glave Testino Luis Miguel
Published: March 2023

Esta pequeña historia encierra algunas de las claves para conocer mejor uno de los momentos álgidos de la transición colonial. Se trata de unos quipus que los indios de Parinacocha guardaban con el registro de lo que entregaron en oro y especies durante cinco años, entre 1545 y 1549, en medio de la guerra civil, cuando por orden de Gonzalo Pizarro fueron encomendados en Martín de Robles. El primer encomendero, Diego de Gumiel, fue ejecutado por Pizarro, al parecer por alguna intervención de Robles, quien vino a recibir en recompensa el repartimiento del finado. La vida posterior de Robles fue particularmente turbulenta, hasta que fue ejecutado por el oidor Diego González Altamirano por orden del virrey, cuando ya las rebeliones civiles habían pasado su punto más alto y parecía que había salido indemne a pesar de su comprometido protagonismo en una y otra (Platt, Bouysse y Harris 2006: 227-246).
Stories to Wake Up: Women Narratives Reconstructing Themselves as Sociohistorical Subjects
Authors: Barbosa-Corredor Jose Adriano
Published: March 2023

This article reports on a research conducted at a private university in Colombia, as part of an English language course in which the topics of study addressed the culture and history of Colombia and Boyacá through art. Narratives from three female students were analyzed, from a decolonial perspective, to observe their processes of reconstruction as sociohistorical subjects taking into account their experiences in the contexts where they study, live in, and come from. The data for this research was gathered inside and outside the classroom through learners’ diaries and dialogical interviews held with the researcher. Narratives served the purpose of making visible elements of those processes and allowed to explore three of them: (1) The construction of particular relationships in and with the world; (2) a perception of unity of past, present, and future; and (3) a sense of their personal and spiritual growth in time. Nevertheless, the narrative of each participant had unique features and values. The results showed that each female had specific anecdotes constructing their experiences, relationships, and plans in their world. One conclusion of the study refers to how the relevance of family, context, childhood memories, and life expectations offer meaningful and memorable topics of discussion within English language lessons for undergraduate learners.
The Impact of TBI on Intermediate Students’ Writing skills in Online Classes at a Private Institute in Cartagena de Indias
Authors: Garcia-Echeverry Adriana , Novozhenina Alexandra
Published: March 2023

This qualitative research project aims to determine the impact that Task-Based Instruction had on fifteen Intermediate English language students´ writing skills in online classes at a private institute in Cartagena. A journal, a questionnaire, and a checklist were used as instruments to collect information during the diagnostic stage. During the action stage, six workshops were implemented, each with a different writing strategy: webbing, peer-editing, asking questions to revise writing, revising and editing, using templates, and reorganizing ideas. At this stage, the same instruments were used to measure the impact of the strategy and to achieve the research objectives. Results show that implementing six online workshops predicated on the task-based instruction helped the students to improve their writing, learning new vocabulary, use ICT tools, and writing strategies, thus having a positive impact on their English language learning process not only in writing but also in other skills. TBI was favorably accepted by learners and affected positively their writing skills.
Numerical solution of differential-algebraic equations of arbitrary index with Riemann-Liouville derivative
Authors: Bulatov Mikhail V. , Indutskaya Tatyana S.
Published: March 2023

In the article, linear systems of ordinary differential equations of fractional order α∈(0,1) are investigated. In contrast to previously known results, the authors consider the case when the matrix before the fractional differentiation operation is degenerate. Problems in such a formulation are called differential-algebraic equations of fractional order. The fundamental differences of such systems from the classical problems of fractional differentiation and integration are emphasized, namely, the systems under consideration can have an infinite number of solutions, or a solution of the original problem depends on the high fractional derivative of the right-hand side. Corresponding examples are given. The authors pass to a different, equivalent formulation of the problem, namely, they rewrite it in the form of a system of linear integral equations of the Abel type (with a weak singularity). This technique allows one to use the apparatus of regular matrix bundles to investigate the existence and uniqueness of the original problem. Using this result, the authors give sufficient conditions for the existence of a unique solution to the class of problems under consideration. Further, an algorithm for the numerical solution of such equations is proposed. The method is based on the product integration method and the quadrature formula of right rectangles. Calculations and graphs of the errors of the proposed method for various fractional differentiation exponents and various indices of the initial matrix bundles are presented.
La segregación en la escuela concertada. Un análisis a través de las actividades complementarias
Authors: Cuartero Cobo María del Mar
Published: March 2023

La capacidad de las escuelas concertadas de seleccionar al alumnado más aventajado socioeconómicamente es una de las causas que explican la creciente segregación escolar en España. A pesar de que la educación obligatoria se debe impartir gratuitamente, para garantizar la libertad de elección de centro de todas las familias, está extendido el cobro de las denominadas «cuotas voluntarias», que se justifican por la oferta de actividades complementarias. La ambigüedad de los preceptos que regulan dichas actividades se hizo patente durante el estado de alarma a raíz de la pandemia de COVID-19. Por ello, regiones como la Comunidad de Madrid oCataluña se apresuraron a promulgar medidas que garantizaran la voluntariedad real de estasactividades y/o la equidad en el acceso con independencia de la capacidad socioeconómica delas familias. Este trabajo pretende explicar por qué, paradójicamente, intentar garantizar lavoluntariedad e incluso la gratuidad de dichas actividades nos alejan del objetivo de lograr unsistema educativo justo.
Anti-oxidant and Whitening Effect of Low Molecular Weight Kaki-tannin with Gamma irradiation
Authors: So Kyeong Seok , Kim Jin Hyun , Lim Yeo Jin , Jeong Ju Tae , Seo Jae Yong , Cha Young Kwon , Cho Hyun Dae , Cho Hang eui , Bae Seunghee
Published: March 2023

Purpose: This study aimed to investigate the use of purified Kaki-tannin obtained from a Korean natural product, Diospyros kaki Thumb. In order to confirm the potential application of kaki-tannin to cosmetics, the efficacy was evaluated by kakit-annin that molecular weight decreased by gamma irradiation.Methods: Kaki-tannin polymer was extracted by hydrothermal extraction from persimmon. The molecular weight of Kaki-tannin polymer reduced by gamma-ray irradiation, and then separated and purified. Further, the molecular weight of this polymer was reduced by gamma-ray irradiation; subsequently, it was separated and purified. Radical scavenging activities of this reduced molecular weight Kaki-tannin were examined by the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical, 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) diammonium salt radical cation, and hydroxyl radical scavenging assays. Moreover, the inhibitory effects of Kaki-tannin on tyrosinase and melanin synthesis in B16F10 melanoma cells were measured in vitro. Furthermore, the expression of tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)-1, and TRP-2 during melanogenesis was confirmed by western blotting.Results: Irradiated Kaki-tannin exhibited an antioxidant effect as well as suppressed tyrosinase activity and melanogenesis. The results of this study confirmed that the expression of tyrosinase, MITF, and TRP-2 decreased as the treatment of irradiated Kaki-tannin increased.Conclusion: In the present study, to incorporate high molecular weight Kaki-tannin in cosmetics, it was first irradiated with gamma rays in order to reduce its weight. This study confirmed that Kaki-tannin irradiated by gamma-ray has antioxidant and whitening effects as well as the potential to be used as a cosmetic material.
The feasibility of nipple-sparing mastectomy in combined with abdominal free flap breast reconstruction without skin paddles for flap monitoring: a single-center experience
Authors: Zhu Liling , Chen Kai , Li Shunrong , Zhang Songliang , Zhang Xiaolan , Yan Jingwen , Wang Shuai , Tan Lunyuan , Rao Nanyan
Published: March 2023

Background

Nipple-sparing mastectomy in combination with buried abdominal free flap breast reconstruction without leaving any skin paddles for post-operative monitoring might be associated with better cosmetic outcomes. The feasibility of this approach remains unclear while a detailed and validated protocol of post-operative flap monitoring is lacking.

Materials and Methods

Eligible patients receiving abdominal free-flap breast reconstruction between 2015 and 2020 in our institution were included. Patients were categorized into the buried-flap cohort and the skin-paddle cohort based on whether a skin paddle remained for direct visual monitoring post-operatively. We reported the learning curve of this surgery and the determinants of operative and/or ischemic time. The oncological outcomes and surgical complications rates were also analyzed.

Results

This study included 147 eligible patients (buried-flap cohort: N = 18; skin-paddle cohort: N = 129). In early-stage patients with immediate breast reconstruction (N = 104), there were no observed relapse events with a median follow-up time of 18 months. The learning curve analysis showed significant reduction of the surgery time and the ischemic time with accumulation of surgical experience after 30 cases. The surgery time and ischemic time were significantly shorter in the buried flap cohort, when compared to that of the skin-paddle cohort. The take-back surgery rates, flap failure rates, and other complication rates were similar between two cohorts under the intra- and post-operative monitoring protocol.

Conclusion

This study supported the feasibility of autologous abdominal free-flap breast reconstruction using the buried flap approach, and we validated our intra- and post-operative monitoring protocol. A multicenter and prospective study is needed to validate this approach.
Trial registration：NCT05560633
Vibroscape analysis reveals acoustic niche overlap and plastic alteration of vibratory courtship signals in ground-dwelling wolf spiders
Authors: Choi Noori , Miller Pat , Hebets Eileen
Published: March 2023

Soundscape ecology has enabled researchers to investigate natural interactions among biotic and abiotic sounds as well as their influence on local animals. To expand the scope of soundscape ecology to encompass substrate-borne vibrations (i.e. vibroscapes), we developed methods for recording and analyzing sounds produced by ground-dwelling arthropods to characterize the vibroscape of a deciduous forest floor using inexpensive contact microphone arrays followed by automated sound filtering and detection in large audio datasets. Through the collected data, we tested the hypothesis that closely related species of Schizocosa wolf spider partition their acoustic niche. In contrast to previous studies on acoustic niche partitioning, two closely related species - S. stridulans and S. uetzi - showed high acoustic niche overlap across space, time, and/or signal structure. Finally, we examined whether substrate-borne noise, including anthropogenic noise (e.g., airplanes) and heterospecific signals, promotes behavioral plasticity in signaling behavior to reduce the risk of signal interference. We found that all three focal Schizocosa species increased the dominant frequency of their vibratory courtship signals in noisier signaling environments. Also, S. stridulans males displayed increased vibratory signal complexity with an increased abundance of S. uetzi, their sister species with which they are highly overlapped in the acoustic niche.
Identification of molecular markers of immune cell infiltration in diabetic nephropathy by weighted gene co-expression network analysis (WGCNA)
Authors: Zhou Jianlong , Zhu Lv
Published: March 2023

Background
Increasing evidence has indicated that infiltrating immune cells play an important role in the pathogenesis of diabetic nephropathy (DN). However, there are relatively few systematic studies on the immunity in DN.
Methods
The Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) algorithm was used to calculate the proportion of immune cells in the GSE96804 and GSE30528 datasets, and to find the differential immune cells between DN and normal samples. The immune cell-related genes were searched by weighted gene co-expression network analysis (WGCNA), and the differentially expressed immune cell-related genes were obtained by taking intersection with differentially expressed genes (DEGs) between DN and normal samples in the two datasets. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to investigate the biological functions of differentially expressed immune cell-related genes. Furthermore, multiple machines learning analyses, including Least absolute shrinkage and selection operator (LASSO) regression algorithm, XGBoost algorithm, and random forest algorithm, and ROC analyses were used to screen diagnostic genes. Finally, Gene Set Enrichment Analysis (GSEA) was performed to investigate the functions of diagnostic genes. A competing endogenous RNA (ceRNA) network was constructed and the target drugs were queried in the Drug Gene Interaction Database (DGIdb).
Results
The nine immune cells and six immune cells with significant differences between DN and normal samples in the GSE96804 dataset and GSE30528 dataset were intersected to obtain five co-regulated immune cells. In addition, the 321 immune cell-related genes were intersected with 65 DEGs between DN and normal samples to obtain 13 differentially expressed immune cell-related genes, including one down-regulated gene and 12 up-regulated gene in DN samples compared with normal samples. These 13 differentially expressed immune cell-related genes were mainly associated with extracellular matrix, Protein digestion and absorption, and ECM-receptor Interaction pathway responses. Furthermore, NAP1L2, MOXD1, COL1A2, COL15A1, and LUM were identified as diagnostic genes by multiple machine learning analysis and AUC evaluation. Finally, GSEA revealed that NAP1L2, MOXD1, COL1A2, COL15A1, and LUM were mainly related to immune response, amino acid metabolic, EMC-receptor interaction. Based on the diagnostic genes, 647 lncRNA-miRNA pairs were created and used to build the ceRNA network. Two targeted drugs, COL1A2 and COL15A1, were acquired in the DGIdb database.
Conclusion
In conclusion, NAP1L2, MOXD1, COL1A2, COL15A1, and LUM might be used as diagnostic biomarkers and therapeutic targets.
Effect of sodium hexametaphosphate modification on dispersion stability of natural brucite in aqueous media
Authors: ZHAO Li-dong , ZHONG Ya-dong , Zhang Rui lei , Zhao Hua , LIU Run-jing
Published: March 2023

Natural brucite is unstable in aqueous media, was modified with sodium hexametaphosphate(SHMP) as a surface treatment. In order to explore the effect of sodium hexametaphosphate on the surface of brucite were studied by using relative sedimentation measurement, scanning electron microscopy (SEM), Zeta potential, infrared spectroscopy (FT-IR) and extend DLVO theoretical calculation. The sedimentation experiments show that the sodium hexametaphosphate modification have a positive effect on the dispersion of brucite in aqueous media. The sodium hexametaphosphate changes the potential of the burburite particles, which leads to the increase of electrostatic double layer energy between particles. Infrared spectrum analysis shows that sodium hexametaphosphate can form a hydrophilic complex with magnesium ions on the surface of brucite. DLVO extend theoretical calculation shows that the total energy between brucite particles turned from unfavorable to favorable with the increasing particles distance, and the steric hindrance interaction energy plays a dominant role. The results show that sodium hexametaphosphate have a positive effect on the stability of natural brucite suspension.
Adaptive reversible data hiding scheme based on prediction error histogram shifting to achieve high embedding capacity and keep image visual quality
Authors: Soveiri Reza Ghorbandost , Asaar Maryam Rajabzadeh , Barjoei Pouya Derakhshan
Published: March 2023

Today, with the development of processing technologies and improvement in cloud networks, a large number of photos are transferred in networks. The need to hide data and maintain security attracted the attention of researchers. In this paper, a reversible data hiding method based on the prediction error histogram shifting is proposed in order to increase the embedding capacity and maintains the visual quality of the image as well. To reach these goals, the original image is transformed into block-wise and for each block the prediction method is figured based on the proposed method to create prediction errors. According to our prediction method, in each block, 75% of the prediction error pixels can find the ability to embed information. The experimental results show a good acceptable embedding capacity as it is clear in a sample test image of an airplane. In this case, the embedding capacity of 206,270 bits and a Peak Signal-to-Noise Ratio (PSNR) of 50/99 have been reached. These results show the efficiency of our proposed method based on the embedding capacity and visual quality of the images. The outcomes of the proposed method reach better results than the main competitor methods.
Ms.FPOP: an exact and fast segmentation algorithm with a multiscale penalty
Authors: Liehrmann Arnaud , Rigaill Guillem
Published: March 2023

Given a time series in Rn with a piecewise constant mean and independent noises, we propose an exact dynamic programming algorithm to minimize a least square criterion with a multiscale penalty promoting well-spread changepoints. Such a penalty has been proposed in Verzelen et al. (2020), and it achieves optimal rates for changepoint detection and changepoint localization. Our proposed algorithm, named Ms.FPOP, extends functional pruning ideas of Rigaill (2015) and Maidstone et al. (2017) to multiscale penalties. For large signals, n ≥ 105, with relatively few real changepoints, Ms.FPOP is typically quasi-linear and an order of magnitude faster than PELT. We propose an efficient C++ implementation interfaced with R of Ms.FPOP allowing to segment a profile of up to n = 106 in a matter of seconds. Finally, we illustrate on simple simulations that for large enough profiles (n ≥ 104) Ms.FPOP using the multiscale penalty of Verzelen et al. (2020) is typically more powerfull than FPOP using the classical BIC penalty of Yao (1989).
The Effect of Sub-chronic Linuron Exposure on Thyroid, Liver, and Kidney
Function in Male Wistar Rats
Authors: Medila Ifriqya , Toumi Ikram , Adaika Aicha , Amrani Aya , Riab Messaouda , Boudebia Ouafa
Published: March 2023

Background:

Herbicides are routinely used to control noxious plants. Most of these chemicals may cause toxicity and endocrine disruption in humans and wildlife.

Objective:

This study aimed to evaluate the influence of linuron on thyroid hormone levels and some hepatic and renal parameters and organ (thyroid, liver and kidney) structures to assume their toxicity toward experimental animals and to evaluate the endocrine disrupting capacity of this chemical.

Methods:

Two groups (8 rats each) were used for an in vivo study. The lot I served as control. Lot II was exposed to 40mg/200mg/day pesticide for 50 days. Changes in hepatic and renal parameters and histological structure were investigated in different treated groups.

Results:

Data from this study showed that linuron altered thyroid function as evidenced by abnormal TSH, T4, and T3 levels. Furthermore, exposure to linuron induces a significant decrease in body weight and a significant increase in aspartate aminotransferase, alanine transaminase, total bilirubin, uric acid, creatinine, glutathione, and malondialdehyde. Previous data were confirmed through the histopathological examination of different organs.

Conclusions:

The most used phenylurea herbicide, linuron, disrupted thyroid function at a 40mg/200mg/day dose and produced oxidative stress in the liver and kidney in male Wistar rats. The data of this study warrant further investigation.