bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex Differences in Patients With Chronic Heart Failure With Reference to Left Ventricular Ejection Fraction
Authors: Sakata Yasuhiko , Miyata Satoshi , Nochioka Kotaro , Miura Masanobu , Shiroto Takashi , Shimokawa Hiroaki
Published: July 2018

Background:

Data on sex differences in heart failure (HF) with reference to left ventricular ejection fraction (LVEF) are limited.

Methods and Materials:

We examined 4683 consecutive patients (mean 69 years) with HF in the CHART-2 study.

Results:

Compared to men (N = 3188), women with HF (N = 1495) were older and had a lower prevalence of ischemic heart disease and cancer, received less implementation of evidence-based treatment, and were characterized by more severe HF in terms of higher New York Heart Association (NYHA) functional class and increased brain natriuretic peptide (BNP) levels, despite greater preservation of LVEF. During the median 6.3-year follow-up, all-cause mortality was comparable between women and men (32.8% vs 33.2%, P = .816), while women had higher cardiovascular mortality, particularly among those with LVEF ≥50%. Although no sex differences existed in cause of death among patients with LVEF ≤ 40% and 41% to 49%, women had a higher proportion of cardiovascular death and lower proportion of noncardiovascular death than men among those with LVEF ≥ 50%. Multivariable Cox regression models showed that women with HF had reduced risk of both cardiovascular and noncardiovascular death, regardless of LVEF category. Beta-blockers were associated with improved mortality in women but not men with LVEF ≤ 40%, while renin–angiotensin system inhibitors were not associated with improved mortality in women with LVEF ≥ 50% but were in men.

Conclusion:

In addition to sex-specific differences in the age of onset, etiology and response to treatment, women with heart failure and preserved left ventricular ejection fraction (LVEF ≥ 50%) have higher cardiovascular mortality than men. Sex-related management of congestive heart failure should include a consideration of LVEF.
A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms
Authors: Martínez-Laperche Carolina , Buces Elena , Aguilera-Morillo M. Carmen , Picornell Antoni , González-Rivera Milagros , Lillo Rosa , Santos Nazly , Martín-Antonio Beatriz , Guillem Vicent , Nieto José B. , González Marcos , de la Cámara Rafael , Brunet Salut , Jiménez-Velasco Antonio , Espigado Ildefonso , Vallejo Carlos , Sampol Antonia , Bellón José María , Serrano David , Kwon Mi , Gayoso Jorge , Balsalobre Pascual , Urbano-Izpizua Álvaro , Solano Carlos , Gallardo David , Díez-Martín José Luis , Romo Juan , Buño Ismael
Published: July 2018

Key Points

A risk model using donor and recipient cytokine gene polymorphisms and clinical variables significantly improves GVHD risk stratification. The model is useful in identifying patients with low-risk of developing severe GVHD, but results must be confirmed in prospective studies.
Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial
Authors: Cardenas Jessica C. , Zhang Xu , Fox Erin E. , Cotton Bryan A. , Hess John R. , Schreiber Martin A. , Wade Charles E. , Holcomb John B.
Published: July 2018

Key Points

Early platelet administration is associated with improved hemostasis and reduced mortality in severely injured, bleeding trauma patients.
Abiraterone Alone or in Combination With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer With Rising Prostate-Specific Antigen During Enzalutamide Treatment
Authors: Attard Gerhardt , Borre Michael , Gurney Howard , Loriot Yohann , Andresen-Daniil Corina , Kalleda Ranjith , Pham Trinh , Taplin Mary-Ellen ,   on behalf of the PLATO collaborators
Published: July 2018

Purpose

Enzalutamide resistance could result from raised androgens and be overcome by combination with abiraterone acetate. PLATO ( ClinicalTrials.gov identifier: NCT01995513) interrogated this hypothesis using a randomized, double-blind, placebo-controlled design.

Patients and Methods

In period one, men with chemotherapy-naïve metastatic castration-resistant prostate cancer received open-label enzalutamide 160 mg daily. Men with no prostate-specific antigen (PSA) increase at weeks 13 and 21 were treated until PSA progression (≥ 25% increase and ≥ 2 ng/mL above nadir), then randomly assigned at a one-to-one ratio in period two to abiraterone acetate 1,000 mg daily and prednisone 5 mg twice daily with either enzalutamide or placebo (combination or control group, respectively) until disease progression as defined by the primary end point: progression-free survival (radiographic or unequivocal clinical progression or death during study). Secondary end points included time to PSA progression and PSA response in period two.

Results

Of 509 patients enrolled in period one, 251 were randomly assigned in period two. Median progression-free survival was 5.7 months in the combination group and 5.6 months in the control group (hazard ratio, 0.83; 95% CI, 0.61 to 1.12; P = .22). There was no difference in the secondary end points. Grade 3 hypertension (10% v 2%) and increased ALT (6% v 2%) or AST (2% v 0%) were more frequent in the combination than the control group.

Conclusion

Combining enzalutamide with abiraterone acetate and prednisone is not indicated after PSA progression during treatment with enzalutamide alone; hypertension and elevated liver enzymes are more frequent with combination therapy.
Feminizing Adrenocortical Carcinoma: The Source of Estrogen Production and the Role of Adrenal-Gonadal Dedifferentiation
Authors: Wu Luming , Xie Jing , Jiang Lei , Su TingWei , Ye Lei , Zhou Weiwei , Jiang Yiran , Zhang Cui , Ning Guang , Wang Weiqing
Published: July 2018

Background

Feminizing adrenocortical carcinoma (ACC) is rare. The source of estrogen production and the underlying mechanism remain unclear.

Objective

In the current study, we investigated the source and the molecular mechanism of estrogen production in feminizing ACC.

Methods

A total of 46 consecutive patients with a diagnosis of ACC were recruited in our center. We described the clinical characteristics and steroid hormone profile of the peripheral and adrenal vein. In both feminizing ACC tissues and cell lines, we investigated the expression of steroidogenic biomarkers and β-catenin pathways by quantitative PCR and immunohistochemical staining. The effects of Wnt inhibitors on steroidogenesis were also analyzed in NCI-H295R cells.

Results

A total of 46 consecutive patients with ACC were analyzed, and 25 had functional ACC. Four patients received a diagnosis of feminizing ACC based on feminizing manifestations, high levels of estradiol that were normalized after surgery, and histological Weiss score. Gonadal steroidogenic biomarkers including CYP19A1, HSD17B3, and LHCGR were markedly elevated in the feminizing ACC tissues. Adrenal vein sampling and liquid chromatography–tandem mass spectrometry suggested high CYP19A1 activity in the adrenal mass. β-catenin expression was also elevated. When treated with niclosamide and PNU-74654, the H295R cell line showed a decrease in β-catenin expression, cell proliferation, and steroid secretion. All steroid hormone enzymes were inhibited, whereas CYP19A1, HSD17B3, and LHCGR mRNA increased.

Conclusions

Feminizing ACC can express high levels of CYP19A1, thus ectopically producing estrogens. Wnt pathway activation and dedifferentiation toward common adrenal-gonadal precursor cells may be the underlying mechanisms.
The Stress Hormone Cortisol Enhances Interferon-ϒ–Mediated Proinflammatory Responses of Human Immune Cells
Authors: Yeager Mark P. , Guyre Cheryl A. , Sites Brian D. , Collins Jane E. , Pioli Patricia A. , Guyre Paul M.
Published: July 2018

BACKGROUND:

Cortisol is a prototypical human stress hormone essential for life, yet the precise role of cortisol in the human stress response to injury or infection is still uncertain. Glucocorticoids (GCs) such as cortisol are widely understood to suppress inflammation and immunity. However, recent research shows that GCs also induce delayed immune effects manifesting as immune stimulation. In this study, we show that cortisol enhances the immune-stimulating effects of a prototypical proinflammatory cytokine, interferon-ϒ (IFN-ϒ). We tested the hypothesis that cortisol enhances IFN-ϒ–mediated proinflammatory responses of human mononuclear phagocytes (monocyte/macrophages [MOs]) stimulated by bacterial endotoxin (lipopolysaccharide [LPS]).

METHODS:

Human MOs were cultured for 18 hours with or without IFN-ϒ and/or cortisol before LPS stimulation. MO differentiation factors granulocyte-macrophage colony stimulating factor (GM-CSF) or M-CSF were added to separate cultures. We also compared the inflammatory response with an acute, 4-hour MO incubation with IFN-ϒ plus cortisol and LPS to a delayed 18-hour incubation with cortisol before LPS exposure. MO activation was assessed by interleukin-6 (IL-6) release and by multiplex analysis of pro- and anti-inflammatory soluble mediators.

RESULTS:

After the 18-hour incubation, we observed that cortisol significantly increased LPS-stimulated IL-6 release from IFN-ϒ–treated undifferentiated MOs. In GM-CSF–pretreated MOs, cortisol increased IFN-ϒ–mediated IL-6 release by >4-fold and release of the immune stimulant IFN-α2 (IFN-α2) by >3-fold, while suppressing release of the anti-inflammatory mediator, IL-1 receptor antagonist to 15% of control. These results were reversed by either the GC receptor antagonist RU486 or by an IFN-ϒ receptor type 1 antibody antagonist. Cortisol alone increased expression of the IFN-ϒ receptor type 1 on undifferentiated and GM-CSF–treated MOs. In contrast, an acute 4-hour incubation of MOs with IFN-ϒ and cortisol showed classic suppression of the IL-6 response to LPS.

CONCLUSIONS:

These results reveal a surprisingly robust proinflammatory interaction between the human stress response hormone cortisol and the immune activating cytokine IFN-ϒ. The results support an emerging physiological model with an adaptive role for cortisol, wherein acute release of cortisol suppresses early proinflammatory responses but also primes immune cells for an augmented response to a subsequent immune challenge. These findings have broad clinical implications and provide an experimental framework to examine individual differences, mechanisms, and translational implications of cortisol-enhanced immune responses in humans.
Vascular endothelial growth factor signaling in development and disease
Authors: Karaman Sinem , Leppänen Veli-Matti , Alitalo Kari
Published: July 2018

Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind to their cognate tyrosine kinase VEGF receptors (VEGFRs) in endothelial cells to elicit various downstream effects. In recent years, there has been tremendous progress in elucidating different VEGF/VEGFR signaling functions in both the blood and lymphatic vascular systems. Here, and in the accompanying poster, we present key elements of the VEGF/VEGFR pathway and highlight the classical and newly discovered functions of VEGF signaling in blood and lymphatic vessel development and pathology.
Probiotics against airway allergy: host factors to consider
Authors: Spacova Irina , Ceuppens Jan L. , Seys Sven F. , Petrova Mariya I. , Lebeer Sarah
Published: July 2018

The worldwide prevalence of allergic diseases has drastically increased in the past decades. Recent studies underline the importance of microbial exposure for the development of a balanced immune system. Consequently, probiotic bacteria are emerging as a safe and natural strategy for allergy prevention and treatment. However, clinical probiotic intervention studies have so far yielded conflicting results. There is increasing awareness about the importance of host-associated factors that determine whether an individual will respond to a specific probiotic treatment, and it is therefore crucial to promote a knowledge-based instead of an empirical selection of promising probiotic strains and their administration regimen.

In this Review, we summarize the insights from animal model studies of allergic disease, which reveal how host-related factors – such as genetic makeup, sex, age and microbiological status – can impact the outcomes of preventive or curative probiotic treatment. We explore why and how these factors can influence the results of probiotic studies and negatively impact the reproducibility in animal experiments. These same factors might profoundly influence the outcomes of human clinical trials, and can potentially explain the conflicting results from probiotic intervention studies. Therefore, we also link these host-related factors to human probiotic study outcomes in the context of airway allergies.
The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity
Authors: Lisowska Justyna , Rödel Claudia Jasmin , Manet Sandra , Miroshnikova Yekaterina A. , Boyault Cyril , Planus Emmanuelle , De Mets Richard , Lee Hsiao-Hui , Destaing Olivier , Mertani Hichem , Boulday Gwénola , Tournier-Lasserve Elisabeth , Balland Martial , Abdelilah-Seyfried Salim , Albiges-Rizo Corinne , Faurobert Eva
Published: July 2018

Endothelial integrity relies on a mechanical crosstalk between intercellular and cell–matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes. RhoA/ROCK-dependent cytoskeletal remodeling is central to the disease, as it causes unbalanced cell adhesion towards increased cell–extracellular matrix adhesions and destabilized cell–cell junctions. This study reveals that CCM proteins directly orchestrate ROCK1 and ROCK2 complementary roles on the mechanics of the endothelium. CCM proteins act as a scaffold, promoting ROCK2 interactions with VE-cadherin and limiting ROCK1 kinase activity. Loss of CCM1 (also known as KRIT1) produces excessive ROCK1-dependent actin stress fibers and destabilizes intercellular junctions. Silencing of ROCK1 but not ROCK2 restores the adhesive and mechanical homeostasis of CCM1 and CCM2-depleted endothelial monolayers, and rescues the cardiovascular defects of ccm1 mutant zebrafish embryos. Conversely, knocking down Rock2 but not Rock1 in wild-type zebrafish embryos generates defects reminiscent of the ccm1 mutant phenotypes. Our study uncovers the role of the CCM1–CCM2 complex in controlling ROCK1 and ROCK2 to preserve endothelial integrity and drive heart morphogenesis. Moreover, it solely identifies the ROCK1 isoform as a potential therapeutic target for the CCM disease.
NEOTECTONIC DEFORMATION OF EASTERN PYLIA ( SW PELOPONNESE , GREECE )
Authors: Ladas I. , Mariolakos I. , Fountoulis I.
Published: July 2018

The present paper aims to the understanding of the effect of the morphotectonic factors on the formation of the morphoneotectonic macrostructures that comprise the eastern part of Pylia Peninsula (SW Péloponnèse). As the broader area of Pylia is one of the tectonically and seismically most active areas of the Hellenic arc, due to the fact that it is very near to the Hellenic trench (approximatly 50Km), the peninsula of Pylia is strongly considered to be a suitable area to study the neotectonic deformation at the Eastern Mediterranean region.
MORPHOTECTONIC ANALYSIS IN THE ELIKI FAULT ZONE (GULF OF CORINTH, GREECE)
Authors: Verrios S. , Zygouri V. , Kokkalas S.
Published: July 2018

Morphotectonic analysis using geomorphic indices has been developed as a basic reconnaissance tool in order to identify areas experiencing rapid tectonic deformation or estimate relative variations of tectonic activity in a specific area. We applied this analysis in Eliki fault zone, which is located in the western part of the Gulf of Corinth. Eliki fault zone was selected because it displays a spectacular geomorphic expression and hosts historic and recent seismicity. The intensity of active tectonics is interpreted through a detailed geomorphic study of the fault-generated mountain fronts and fluvial systems. Tectonic geomorphology analysis of the Eliki footwall area includes the application of the most commonly used geomorphic indices, such as the mountain front sinuosity index (Smf), the valley floor / width ratio index (Vf), the stream gradient index (SL) and the transverse topographic symmetry factor (T). These indices were estimated on topographic maps and aerial photographs of the study area in order to correlate active tectonics and erosional processes. Our results imply that the Eliki fault zone can be assigned to a tectonic class of the higher tectonic activity. However, spatial variations of tectonic activity along the segmented studied fronts point to a general trend of increasing activity towards the east, which is gradually decreasing towards the west.
INVESTIGATION OF THE CAUSES OF THE SLIDING ON THE 123KM ON THE KORINTHOS-TRIPOLIS NATIONAL ROAD AND WORKING TECHNIQUES TO RESTORE THE STABILITY
Authors: Μαρίνος Π. , Καββαδάς M. , Ντουνιάς Γ. , Προβιά Α.
Published: July 2018

The paper deals with the important landslide of a 220m width at the area of the 123km on the Korinthos-Tripolis national road as well as the remedial measures in order to restore the stability of the road. The sliding caused the traffic interruption on the national road at 08/02/2003 and for the next two months. The service was restored after the development of a bypass road on the same position with the sliding. The geomorphological features of the area indicate that there were sliding problems in the past which they became serious after the construction of the national road by the additional load of the embankment of the road and the increased infiltrations. The main remedial work was the toe buttress of the unstable slope by the construction of a 15m high fence in the valley and appropriate drainage on the foot of the sliding and at the same time it is re-arranged the riverbed through the development of a sewer along with the use of a drainage network.
LANDSLIDE PHENOMENA IN KANALIA VILLAGE, FTHIOTIDA PR. AND HANDLING THEIR IMPACTS IN THE RESIDENTIAL DEVELOPMENT OF THE AREA
Authors: Ρόζος Δ. , Αποστολίδης E.
Published: July 2018

In the present paper, the serious landslide phenomena that make difficult the residential development of Kanalia village are studied. Kanalia village is located on a slope of the eastern bank of Roustianitis torrent, the main hydrographie axis of the broader area, which is one of the main branches of Sperchios River. The geological structure of the area (sandstones and siltstones of the Pindos zone flysch) as well as the hydro meteorological and climatological conditions favoring the formation of locally very thick weathering mantle and also the development of seasonal aquifers, were at first studied. As it was confirmed, the main causes of landslide phenomena manifestation are related to the above conditions, to the erosional activity of water in the slopes of the hydrographie axes and finally to the human interventions.These phenomena are observed in five (5) main sites with most important the one affected the South - Southwest part of the village covering the area from KanaliaGardiki provincial road until Roustianitis torrent downwards. In that case, the periodic re-activations of the sliding phenomena during the last forty years have caused full destruction and abandonment of this part of the village, since no relevant measures have been taken so far. The remaining sites are restricted in some parts of the village road network, without affecting residential zones.For the protection and development of the residential area of Kanalia village, the following measures were recommended for the improvement of the ground conditions in the slope affected areas: (a) drainage both of the surficial and ground waters in the vulnerable zones, (b) slope supporting works with gabion walls (flexible structures), (c) protection of the stream slopes from erosion and undermining with gabion walls and gully dams, (d) tree plantations, and (e) suitable and appropriate foundation of the new constructions on the stable basement or foundation using specific types, if necessary. It is suggested the application of these measures for the safety of the road network, the good operation of which constitutes a prerequisite for a safe residential development.
INFLUENCE OF THE MICROSTRUCTURE AND MINERALOGICAL COMPOSITION ON THE LABORATORY HYDRAULIC CONDUCTIVITY OF MARLS FROM NORTHERN PELOPONNESE
Authors: Χριστοδουλοπούλου T. , Τσώλη-Καταγά Π.
Published: July 2018

The role which microstructural characteristics and clay mineralogy plays on the saturated hydraulic conductivity value (k) of marls from Northern Péloponnèse, measured in the laboratory, is studied. This value must be taken under consideration when severe geotechnical problems are investigated (e.g. embankment foundations, landslides phenomena involving clayey sediments, soil conditioning e.t.c.) or empirical functions are applied to predict hydraulic conductivity from basic geotechnical properties. The marly samples were analysed by x-ray diffraction (XRD) and by thermo-gravimetric methods (DTA, TG) for the determination of mineralogical composition of clay fraction and by scanning electron microscopy (SEM) for the study of their microstructure. Their basic physical characteristics (grain-size distribution, e, WL, WP, IP, GS, Yd, n) were also determined. The coefficient of permeability (or hydraulic conductivity, k) was measured by the falling head method and the values obtained range between 1.66 10~8 and 1.06 10"6 cm/s, with a few exceptions. Our results indicate that the occurrence of swelling clay minerals in these cohesive marly sediments influences the value of hydraulic conductivity. Because of the double-layer effect not all the pore space contributes to seepage. Furthermore, the aggregation or flocculation of clay minerals and other microstructural characteristics related to the packing of structural constituents (forming an open or tight microstructure), the shape and the distribution of micropores, and the cementation degree of the microstructure are influence factors that affect the value of k. Predicting k, using empirical functions reported by several researchers for cohesive materials, or from simple correlations, as this of k versus clay fraction which is reported in this paper, is not absolutely safe, especially for cemented sediments as marls. Physicochemical factors, as the above-mentioned, play a prevalent role on the hydraulic conductivity value and they cannot be quantified and accounted in existing models.
HYDROGEOLOGICAL CONDITIONS OF POTAMIA BASIN, CENTRAL GREECE, ASSOCIATED WITH THE PROSPECTIVE LIGNITE EXPLOITATION OF THE AREA
Authors: Βασιλείου E. , Κουμαντάκης I. , Δημητρακόπουλος Δ. , Γρηγοράκου E.
Published: July 2018

In Elassona Hydrological Basin, an area of 85 Km2 in Central Greece, two lignite deposits, Domeniko and Amourio, of 160x106 tn of lignite have been found. The exploitation process of the future open pit lignite mines is highly connected with the existence of surface and ground water in the area. The exploitation of these two lignite deposits will cause changes of the natural and human environment of the area. In this paper the hydrogeological conditions and the hydrodynamic status of surface and ground water of the basin are described. A water management system of the water coming from dewatering process is suggested.
INVESTIGATION OF HYDROGEOLOGICAL AND ENVIRONMENTAL CONDITIONS WITH RESPECT TO THE EXISTANCE OF A CEMETERY WITHIN THE REGION OF THE LIVADIA VILLAGE AT THE ISLAND OF TlLOS
Authors: Περλέρος B. , Αντωνιάδης Κ. , Δρακοπούλου E.
Published: July 2018

The hydrogeological and environmental conditions were investigated, as dictated by national legislation, in order to define the boundaries of the Livadia village, at the island of Tilos. However, since a cemetery is located near the village, an additional study had to be performed, to estimate the possibility to decrease the distance required by law (250 m), between the cemetery and the village boundaries. This study investigated the impact of the cemetery on groundwater and surrounding environment by utilizing the geological, hydrogeological, environmental and chemical data in order to:• Evaluate the significance of underground water according to national and international standards.• Evaluate the flow of underground water.• Evaluate the chemistry of underground water upgradient, downgradient and near the cemetery.• Evaluate the possibility of compound and microbiological load migration from the cemetery and downgradient towards the village.• Locate other possible sources of contamination within the wider area of investigation.• Estimate the influence of the cemetery on surface and underground water • Recommend a groundwater monitoring system.
Σωματικές εμπειρίες, εικόνα σώματος και κοινωνική ταυτότητα ατόμων με τυφλότητα: ποιοτική μελέτη στην Ελλάδα
Authors: Κούτρα Λίνα , Τόγκας Κωνσταντίνος , Αλεξιάς Γεώργιος , Σαββάκης Μάνος , Στρατοπούλου Ιφιγένεια
Published: July 2018

Μολονότι η τύφλωση αποτελεί συχνή μορφή αναπηρίας, οι σωματικές εμπειρίες, η εικόνα σώματος και η κοινωνική ταυτότητα των τυφλών δεν έχουν ερευνηθεί εκτεταμένα. Πραγματοποιήθηκε ποιοτική έρευνα με συνεντεύξεις σε επτά τυφλούς και τα αποτελέσματα έδειξαν ότι η αίσθηση ταυτότητάς τους είναι ισχυρά δομημένη, χωρίς στιγματισμό και χωρίς προβλήματα στην κοινωνικοποίησή τους. Οι τυφλοί αρνούνται τη διαφορετική αντιμετώπιση και βασίζονται στις αισθήσεις τους μόνο για την καθημερινή επιβίωση. Οι σωματικές εμπειρίες είναι βασικές για την  αναγνώριση του περιβάλλοντός τους και η εξωτερική εμφάνιση αποτελεί συστατικό στοιχείο της εικόνας εαυτού. Τα άτομα με προβλήματα όρασης δεν εμφανίζουν αβεβαιότητα και δυσαρέσκεια για το σώμα τους και δεν έχουν προβλήματα με την ανάπτυξη και διατήρηση της θετικής εικόνας του σώματος. Τα αποτελέσματα μπορούν να χρησιμοποιηθούν για την πληρέστερη ψυχοκοινωνική φροντίδα τους.
A educação permanente em saúde no serviço de atendimento móvel de urgência
Authors: Silva Andrielly Barros , Lopes Gabriel Miranda , Batista Kamila Maria Penna , Castro Mônica Cristina Da Silva
Published: July 2018

A Educação Permanente é uma estratégia Política Nacional implantada pelo Ministério da Saúde em 2004, visando a capacitação dos profissionais nos serviços de saúde. Esta pesquisa teve como objetivo, identificar por meio da literatura, as atividades relacionadas à Educação Permanente em Saúde que o Serviço de Atendimento Móvel de Urgência desenvolve no âmbito da prática assistencial. Trata-se de uma Revisão Integrativa da Literatura com recorte temporal de 2012 a 2017 e busca de artigos nas bases de dados da Biblioteca Virtual em Saúde por meio de periódicos na Scientific Electronic Library Online – SCIELO, Literatura Latino-Americana e do Caribe em Ciências da Saúde - LILACS, Base de dados de enfermagem - BDENF e Literatura Internacional em Ciências da Saúde - MEDLINE. Na análise dos dados emergiram três categorias temáticas, sendo apresentadas nos resultados: a primeira categoria - a importância da educação permanente em saúde nos serviços de saúde. Segunda categoria - as estratégias e atividades de educação permanente em saúde. E a terceira categoria - a percepção dos profissionais sobre o processo de educação permanente no Serviço Móvel de Urgência. Obtém-se como resultado a falta de conhecimentos dos profissionais sobre Educação Permanente em Saúde e a importância de conhecer, incorporar e desenvolver atividades voltadas para aperfeiçoamento dos serviços móveis de urgência. Conclui-se que este instrumento é de grande valia para todos os profissionais por gerar mudanças no processo de trabalho dos setores e assim obter uma melhora nas práticas de saúde oferecidas a população diante da realidade local.
Ergonomia aplicada na qualificação da ambiência do espaço de nascer.
Authors: Silva Cristiane Neves da
Published: July 2018

Este estudo tem como objetivo rever as evidências disponíveis sobre o projeto de ambientes destinados ao nascimento, mais especificamente os quartos PPP (pré- parto, parto e puerpério), a fim de identificar características relativas aos aspectos ergonomicos dos ambientes e equipamentos utilizados que possam auxiliar na diminuição do estresse materno e facilitar a fisiologia do parto.  Entendendo-se a ergonomia como uma disciplina dedicada a relacionar o entendimento das interações entre os seres humanos e outros elementos ou sistemas dos ambientes e relacionando-a com as proposições relativas aos estudos de ambiência, que atentam para os aspectos subjetivos que influenciam na percepção do ambiente, busca-se identificar elementos projetuais e ergonômicos que contribuam para experiências de nascimento seguras e satisfatórias para todas as mulheres.
Biyoloji Öğretmen Adaylarının Eleştirel Düşünme Eğilimleri Üzerine Bir İnceleme
Authors: Çakırlar-altuntaş Esra , Yılmaz Miraç , Turan Salih Levent
Published: July 2018

Biyoloji öğretmen adaylarının eleştirel düşünme eğilimlerinin
farklı değişkenler (empatik eğilim, sınıf, akademik başarı) açısından incelenmesini
amaçlayan bu araştırma nicel araştırma yöntemlerinden ilişkisel modelde
desenlemiştir. Bu araştırma, 2015-2016 Eğitim - Öğretim yılı Bahar Dönemi’nde
bir devlet üniversitesinin Biyoloji Eğitimi Anabilim Dalı’nda öğrenim gören 82
biyoloji öğretmen adayının gönüllü katılımı ile gerçekleştirilmiştir. Betimsel
istatistiklerin hesaplandığı, korelasyon ve regresyon analizlerinin yapıldığı
araştırmada California Eleştirel Düşünme Eğilimi Ölçeği, Empatik Eğilim Ölçeği,
ayrıca araştırmacılar tarafından hazırlanan Kişisel Bilgiler Anketi kullanılmıştır.
Elde edilen bulgular sonucunda çalışmaya katılan biyoloji öğretmen adaylarının
eleştirel düşünme eğilimlerinin ve empatik eğilimlerinin orta düzeyde kaldığı, çalışmaya
katılan biyoloji öğretmen adaylarının eleştirel düşünme eğilimleri ile empatik
eğilimleri arasında pozitif yönlü ve orta düzeyli bir korelasyonun varlığı
belirlenmiştir. Ancak söz konusu biyoloji öğretmen adaylarının sınıf düzeyleri ile
akademik başarıları arasında bir korelasyonun varlığı tespit edilememiştir. Ayrıca
söz konusu biyoloji öğretmen adaylarının empatik eğilimlerinin eleştirel
düşünme eğilimlerinde tek yordayıcı değişken olduğu elde edilen bulgulardandır.
Bilinçli Farkındalık Temelli Bilişsel Terapi Programının Üniversite Öğrencilerinin Duygu Düzenleme Güçlüklerini Azaltmadaki Etkisi
Authors: DEMİR Volkan , GÜNDOĞAN Nazire
Published: July 2018

Bu çalışma bilinçli farkındalık temelli bilişsel terapi programının
üniversite öğrencilerinin duygu düzenleme güçlüklerini azaltmadaki etkisini
değerlendirmek amacıyla hazırlanmıştır. Araştırma, öntest-sontest modelli yarı
deneysel bir çalışmadır. Araştırma, İstanbul’da psikoloji bölümünde ikinci ve
üçüncü sınıflarında öğrenim görmekte 10 öğrencinin katılımıyla gerçekleşmiştir.
Ölçme aracı uygulama öncesinde ön-test,
uygulamanın bitiminde ise son-test olarak uygulanmıştır. Araştırmada
katılımcılara sekiz oturumdan oluşan her oturumu 90 dakika süren bir program
uygulanmıştır. Tek grup öntest - sontest kontrol grupsuz yarı deneysel desenin
kullanıldığı çalışmada veriler, Wilcoxon İşaretli Sıra Testi ile
çözümlenmiştir. Yapılan analizler bilinçli farkındalık temelli bilişsel terapi
programının üniversite öğrencilerinin duygu düzenleme güçlüklerini azaltmada
etkili olduğunu göstermiştir. Terapi programının kalıcılığını belirlemek için
grup üyelerine onbeş ay sonra tekrar duygu düzenleme güçlüğü ölçeği uygulanmıştır. Yapılan analiz
sonucunda son-test ile izleme testi puanı arasında bir farkın olmadığı, bu
anlamda yapılan bilinçli farkındalık temelli bilişsel terapi programının uzun
süreli bir etkiye sahip olduğu bulunmuştur.
Our Beloved Kin
Authors: Brooks Lisa
Published: July 2018

With rigorous original scholarship and creative narration, Our Beloved Kin recovers a complex picture of war, captivity, and resistance during the “First Indian War” (later named “King Philip’s War”) by relaying the stories of Weetamoo, a female Wampanoag leader, and James Printer, a Nipmuc scholar, whose stories converge in the captivity of Mary Rowlandson. King Philip’s War (1675-1678) is often viewed as the quintessential moment of colonial conquest and Native resistance, but these stories reveal a historical landscape much more complex than its original Puritan narrators conveyed. Our Beloved Kin also draws readers beyond the locus of most narratives of the war, southern New England, into the northern front, the vast interior of Wabanaki, where the war continued long beyond the death of “King Philip.” Beginning and ending at Caskoak, a place of diplomacy, the book explores the movement of survivors seeking refuge, captives taken in war, and Indigenous leaders pursuing diplomacy in vast Indigenous networks across the northeast. Supplemented by thirteen maps and an interactive website, Our Beloved Kin takes readers into Indigenous geographies, braiding together research in historical archives, including little-known revelatory documents, interpretive frameworks drawn from Indigenous languages, and place-based history which arises from reading “the archive of the land” to offer a compelling new interpretation of “King Philip’s War.”
Critique of Religious Discourse
Authors: Abu Zayd Nasr Hamid
Published: July 2018

First published in Arabic in 1994, this book's controversial approach argued that conventional fundamentalist interpretations of the Quran and other Islamic religious texts are ahistorical and misleading. Conservative religious leaders accused this book's author of apostasy. Marking the first time a work by this author is available in its entirety in any Western language, this English edition makes the author's erudite interpretation of classical Islamic thought accessible to a wider audience at a critical historical moment. The book discusses the life and work of Nasr Hamid Abu Zayd (1943–2010); the rise of the Islamist movement, a phenomenon that Islamists call the Awakening; religious discourse; the Islamic left; and the problematic aspects of reading the religious texts themselves.
The Steam Mill and Jacksonian Politics: The Career of William N. Jeffers
Authors: Bendler Bruce A.
Published: July 2018

Political and economic transitions reshaped New Jersey as they did throughout the United States during the 1820s. By the end of that decade an emergent second party system, centered on support of or opposition to Andrew Jackson, defined both national and state elections. The “Market Revolution” had begun to transform the nation’s economy. Industrialization and improvements in the transportation network led to the eclipse of purely local markets by national ones. Politicians and entrepreneurs at the local level sought to adapt to such transitions. William N. Jeffers of Salem County, New Jersey, so adapted his approach to both political and economic relationships. Jeffers furthered his political ambitions by identification with the Jacksonian movement in New Jersey. He sought to advance his economic ambitions by obtaining a charter for a bank and for a steam mill to take advantage of Salem County’s agricultural economy.
"The almighty dollar will buy you, you bet/ A superior class of coronet:" Biographical Sketches of NJ's Gilded Age "Dollar Princesses"
Authors: Ziobro Melissa
Published: July 2018

Season one of the acclaimed historical drama Downton Abbey was set in 1912, but a key element of the show’s storyline, known to all dedicated viewers, occurred years earlier, off screen, when a wealthy, young American heiress named Cora Levinson of Cincinnati married the British Robert Crawley, Viscount Downton, the future Earl of Grantham. As part of their marriage contract, Cora’s fortune would be tied to the Grantham family’s failing estate to prevent it from going bankrupt. In return, Cora would eventually earn the title of Countess of Grantham. While Downton Abbey’s Granthams are fictional, the idea of wealthy American heiresses marrying impoverished European noblemen is not. There were by some counts close to 500 of these marriages in the decades between the end of the Civil War and WWI, and several of the brides had ties to NJ. Who were these women? Can we know what motivated them? Did they find happiness? And how did their “loves lives” impact social norms, transatlantic relations, and the U.S. economy?
Cahn–Hilliard equation on the boundary with bulk condition of Allen–Cahn type
Authors: Colli Pierluigi , Fukao Takeshi
Published: July 2018

The well-posedness of a system of partial differential equations with dynamic boundary conditions is discussed.
This system is a sort of transmission problem between the dynamics in the bulk Ω and on the boundary Γ.
The Poisson equation for the chemical potential and the Allen–Cahn equation for the order parameter in the bulk Ω are considered as auxiliary conditions for solving the Cahn–Hilliard equation on the boundary Γ.
Recently, the well-posedness of this equation with a dynamic boundary condition, both of Cahn–Hilliard type, was discussed.
Based on this result, the existence of the solution and its continuous dependence on the data are proved.
Effect of Nano Zeolite on the Transformation of Cadmium Speciation and Its Uptake by Tobacco in Cadmium-contaminated Soil
Authors: Hu Qiulong , Zeng Wei-ai , Li Fan , Huang Yanning , Gu Songsong , Cai Hailin , Zeng Min , Li Qiang , Tan Lin
Published: July 2018

The study was aimed at exploring the effects of applying ordinary and nano zeolite on the soil pH, soil available cadmium (Cd) content, soil Cd speciation and Cd uptakes by tobacco using pot experiment with simulated Cd contaminated soil indoors. The results showed that soil pH increased and available Cd content reduced with the amount of ordinary and nano zeolite increasing. Compared with the control, the application of ordinary and nano zeolite increased soil pH at 0.47 - 1.05 and 0.73 - 1.57, respectively, and reduced the available Cd contents at 19.3% - 32.7% and 23.2% - 40.5%, respectively. In addition, soil pH had significantly negative correlation with available Cd content in each treatment (p<0.05). Nano zeolite could more effectively reduce Cd contents of all parts of tobacco than ordinary zeolite with the same amount treatments, and Cd content in all parts of tobacco plants was positively correlated with soil available Cd content. The content of exchangeable Cd (EXE) in soil decreased to some extent with different zeolite treatments, application of nano zeolite was better than that of application of ordinary zeolite in reducing Cd bioavailability and transferability. Overall, application of nano zeolite has an advantage over ordinary zeolite in reducing available Cd content in soil and Cd content in tobacco.
Global dynamics and parameter identifiability in a predator-prey interaction model
Authors: Tripathi Jai Prakash , Meghwani Suraj S. , Tyagi Swati , Abbas Syed
Published: July 2018

This paper discusses a predator-prey model with prey refuge. We investigate the role of prey refuge on the existence and stability of the positive equilibrium. The global asymptotic stability of positive interior equilibrium solution is established using suitable Lyapunov functional, which shows that the prey refuge has no influence on the permanence property of the system. Mathematically, we analyze the effect of increase or decrease of prey reserve on the equilibrium states of prey and predator species. To access the usability of proposed predator-prey model in practical scenarios, we also suggest, the use of Levenberg-Marquardt (LM) method for associated parameter estimation problem. Numerical results demonstrate faithful reconstruction of system dynamics by estimated parameter by LM method. The analytical results found in this paper are illustrated with the help of suitable numerical examples
Antibacterial evaluation of CNF/PVAm multilayer modified cellulose fiber and cellulose model surface
Authors: Chen Chao , Ek Monica
Published: July 2018

Earlier studies have shown that 3-layer-modified cellulose fibers with poly(acrylic acid) (PAA) as the middle layer between two cationic polyelectrolyte polyvinylamine (PVAm) layers have strong antibacterial efficacy in terms of both bacteria adsorption and bacterial growth inhibition. In the present work, the fossil-based PAA middle layer was replaced by sustainable wood-based cellulose nano-fibrils (CNF), i. e., the fibers were modified by a 3-layer PVAm/CNF/PVAm system. Interestingly, the antibacterial efficacy of this system was greater than that of the previous PVAm/PAA/PVAm system. A higher salt concentration and lower assembly pH in the multilayer build-up resulted in better bacterial reduction. As the surface of a cellulose fiber is heterogeneous, making it difficult to characterize and visualize at high resolution, more homogeneous cellulose model surfaces were prepared by spin coating the dissolved cellulose fiber onto a silica surface to model the fiber surface. With increasing ionic strength, more aggregated and heterogeneous structures can be observed on the PVAm/CNF/PVAm modified model surfaces. The adsorbed bacteria distributed on the structured surfaces were clearly seen under fluorescence microscopy. Adsorbed amounts of bacteria on either aggregate or flat regions were quantified by scanning electron microscopy (SEM). More adsorbed bacteria were clearly seen on aggregates than on the flat regions at the surfaces. Degrees of bacteria deformation and cell damage were also seen under SEM. The surface roughness of the modified model surfaces was examined by atomic force microscopy (AFM), and a positive correlation was found between the surface roughness and the bacterial adhesion. Thus, an additional factor that controls adhesion, in addition to the surface charge, which is probably the most dominant factor affecting the bacteria adhesion, is the surface structures, such as roughness.
Transmedia branding: Brands, narrative worlds, and the mcwhopper peace agreement
Authors: Scolari A. Carlos
Published: July 2018

In recent years there has been much discussion about the links between brands and storytelling. This article briefly describes transmedia storytelling, reflects on some exemplary works to understand its cultural dynamics, and then focuses on one particular aspect: the development of transmedia strategies in branding. This article delves into that area where branding melts and recombines with storytelling, keeping an eye on transmedia worlds throughout. After presenting a semio-narratological analytical model the article applies the categories to Burger King’s successful and internationally recognized McWhopper campaign (Campaign, Brief. 2015. Y&R’s Burger King “McWhopper” campaign: How a big idea from little New Zealand went global (interview to Tom Paine). Campaign Brief December 31. http://www.campaignbrief.com/ (accessed 16 October 2016)). The analysis spans from the construction of McWhopper’s storytelling to the positioning of competitors in this particular transmedia narrative world. The article concludes with a series of reflections and recommendations for applying semio-narratologic categories to transmedia branding analysis and design.
A Word on Kosovo’s First Ten Years
Authors: Austin Robert C.
Published: July 2018

Kosovo celebrated ten years of fraught independence in February. While there were some good reasons to celebrate, Kosovo still hovers between a failed and a functioning state. Its main economic indicators are extremely bad with no signs of improving. Unemployment, particularly among its youth, is feeding an ongoing brain drain. The legacy of the United Nations Mission (UNMIK) and now the European Union Mission (EULEX) is mixed, but neither was successful in creating the conditions for Kosovo to function as a normal state. Agreements between Belgrade and Prishtina to provide more rights to the Serb communities especially in the north have undermined Kosovo’s sovereignty. Now, the buzz in Prishtina speaks of a territorial swap between Serbia and Kosovo that would pave the way for mutual recognition. The domestic elite have proven more interested in short term survival and profit than in making historic progress. A stale consensus prevails that maybe this is the best that can be hoped for.
First representatives of (210)-oriented perovskite variants−Synthesis, crystal structures and properties of the new 2D hybrid perovskites A[HC(NH2)2]PbI4; A=[C(NH2)3], [HSC(NH2)2]
Authors: Daub Michael , Hillebrecht Harald
Published: July 2018

Single crystals of [C(NH2)3][HC(NH2)2]PbI4 (GuFAPbI4) and [HSC(NH2)2][HC(NH2)2]PbI4 (TuFAPbI4) were obtained from solutions of the binary halides in HI or DMF. Large crystals grown from HI are dark-brown while single phase powders synthesized from DMF are orange. The crystal structure of GuFAPbI4 (I2/m, Z=12, a=14.3147(2), b=12.7591(2), c=25.7377(4)Å), β=101.459(1), 4256 refl., 196 param., R1=0.024, wR2=0.061) represents a 2D perovskite with a new motif similar to Ruddlesden-Popper phases (AX)m(A′BX3)n and m=n=1. The layers are formed by corner-sharing PbI6 octahedra. According to the cut-out of the 3-D perovskite the structure of GuFAPbI4 can be assigned as a (210)-oriented representative. So one octahedron is linked in trans-position and two in cis-orientation. The structure of TuFAPbI4 (P21/n, Z=12, a=14.4208(6), b=12.7545(7), c=26.3982(11) Å), β=100.609(3)°, 6808 refl., 275 param., R1=0.048, wR2=0.096) represents a simple distortion variant of GuFAPbI4. GuFAPbI4 and TuFAPbI4 were further characterized by vibrational spectroscopy and optical spectroscopy. The optical band gap was determined as 2.34 eV in agreement to the observed color. So both compounds are not suitable as a dye in the PSC perovskite solar cell. Similar to other Pb-containing 2D perovskites there is a significant excitonic peak (2.31 eV). TuFAPbI4 represents the first example with protonated thiourea as an organic cation. Therefore, we characterized protonated thiourea iodide and introduce protonated thiourea [HSC(NH2)2]+ as a new cation for hybrid halogeno perovskites.
Older Adults' Sedentary Behavior and Physical Activity After Hip Fracture: Results From an Outpatient Rehabilitation Randomized Controlled Trial
Authors: Zusman Enav Z. , Dawes Martin , Fleig Lena , McAllister Megan M. , Cook Wendy L. , Guy Pierre , Brasher Penelope M. A. , McKay Heather A. , Khan Karim M. , Ashe Maureen C.
Published: July 2018

Background and Purpose:

Prolonged sedentary time and limited physical activity can result in deleterious effects on health and mobility, especially for older adults with fall-related hip fracture. Therefore, the purpose of this study was to examine the effect of a multidisciplinary clinic on sedentary behavior and physical activity (prespecified secondary outcomes) and provide descriptions of activity patterns over 1 year for men and women.

Methods:

We conducted a parallel-group, single-blinded randomized controlled trial comparing a multidisciplinary clinic and usual care (intervention) with usual care (control). We recruited 53 community-dwelling older adults aged 65+ years who were 3 to 12 months postfracture and collected data at baseline, 6, and 12 months; study staff were blinded to group allocation. The clinic included a geriatric assessment by the geriatrician, physiotherapist, and occupational therapist. Referrals were made to other professionals, when indicated. We collected the accelerometer-measured sedentary behavior and physical activity at 3 time points. We used linear mixed-effects models to compare groups at 6 and 12 months and mixed models to compare outcomes between men and women.

Results:

Participants were sedentary for more than 10 hours of a 13-hour day, and there were no significant differences between the study groups at 6 months (2.4 [95% confidence interval: −22.4 to 27.2] minutes) or 12 months (−3.7 [95% confidence interval: −33.6 to 26.1] minutes). Compared with women, men spent 47.2 min/d more in sedentary time (P = .052) and 43.8 min/d less in light physical activity (P = .047).

Discussion:

Older adults after hip fracture spend prolonged periods of waking hours sedentary with very little activity.