bluuebunny/crossref_metadata_2025 huggingface dataset:
New Cytotoxic Steroid Produced by the Soil-Derived Fungus Aspergillus flavus JDW-1
Authors: Guo Wenqiang , Liu Wenjie , Xiao Feng , Zhang Miaomiao , Li Longqiang , Yang Ping , Chen Chunchen
Published: May 2019

One new steroid 1, together with seven known compounds 2 to 8, were discovered in the extract of a soil-derived fungus Aspergillus flavus JDW-1. The structure, including the absolute stereochemistry of new compound 1, was established by interpretation of extensive nuclear magnetic resonance spectroscopic data and further confirmed by X-ray crystallographic analysis. The cytotoxicity of 1 against the A-549, Hela, HCT-116, MGC-803, and HO-8910 cell lines was evaluated, which showed cytotoxicity with the half-maximal inhibitory concentration (IC50) values as 5.00 to 22.38 μM. Compounds 2 to 8 exhibited moderate radical scavenging activity against DPPH with IC50 values ranging from 4.7 to 28.5 μM.
Chemical Compositions of the Essential Oils and Headspace Volatiles of Seseli peucedanoides Plant Parts
Authors: Petrović Goran M. , Stamenković Jelena G. , Jovanović Olga P. , Stojanović Gordana S.
Published: May 2019

The chemical compositions of the essential oils of Seseli peucedanoides (M.Bieb.) Koso-Pol. inflorescences and leaves, isolated by hydrodistillation, and headspace volatiles, obtained by the static headspace method, were analyzed in detail by gas chromatography (GC) and GC/mass spectrometry (MS). In total, 74 constituents were identified, representing more than 98% of the observed GC peaks. The number of identified essential oil components obtained from the inflorescences was 63 while for the leaf essential oil it was 46. A much smaller number of compounds, 26 for inflorescences and 21 for leaves, were detected in the headspace samples. In both essential oils the most abundant compounds were the same, ( E)-caryophyllene and germacrene D, only in different proportions. The main components in the headspace specimens were α-pinene and ( E)-β-ocimene with ( E)-caryophyllene and ( Z)-3-hexen-1-ol also determined in significant percentages. The major class of compounds identified in the investigated essential oils was hydrocarbon sesquiterpenes with a share of over 80%, while the most dominant class of the headspace volatiles was hydrocarbon monoterpenes, which contribute slightly less than 80% of the total.
Ankle Arthrodesis With Anterior Plate Fixation in Patients at High Risk for Nonunion
Authors: Steginsky Brian D. , Suhling Mallory L. , Vora Anand M.
Published: May 2019

Between January 1, 2011, and January 1, 2017, an orthopaedic foot and ankle surgeon performed tibiotalar arthrodesis on 221 patients. Thirty-two were included in this study. Inclusion criteria included patients with at least one risk factor for nonunion and/or malunion, isolated anterior ankle arthrodesis with plate fixation, patients older than 18, and a minimum of 1-year follow-up. Risk factors were avascular necrosis of the talus, severe segmental bone defect, smoking, inflammatory arthropathy, coronal deformity greater than 15°, diabetes mellitus, septic nonunion, failed ankle arthrodesis, and body mass index greater than 35. Functional outcome questionnaires (Ankle Osteoarthritis Score [AOS] and Foot Function Index [FFI]) were collected at the latest visit or by phone. Twenty-six (26/32, 81.2%) patients included in the study had computed tomography images available for review at an average of 3.2 months after surgery. The rate of successful arthrodesis was 93.8% (30/32) at an average of 78 days. Overall, 14 patients (14/32, 43.8%) developed a postoperative complication, including 1 patient that had a delayed nonunion and 2 patients that proceeded to nonunion. Twenty-three patients (23/32, 71.9%) completed the functional outcome questionnaires at an average of 26.8 months. Mean AOS and FFI scores improved significantly postoperatively ( P < .001). Sagittal tibiotalar and coronal tibiotalar alignment improved significantly in patients with severe preoperative deformity ( P < .001). Tibiotalar arthrodesis with anterior plate fixation in a high-risk cohort results in high union rates and significantly improved functional outcomes.

Levels of Evidence: Therapeutic, Level IV: Prospective, comparative trial.
Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis
Authors: Phothijindakul Nicharee , Chusakul Supinda , Aeumjaturapat Songklot , Snidvongs Kornkiat , Kanjanaumporn Jesada , Ruangritchankul Komkrit , Phannaso Chuntima
Published: May 2019

Background

Local allergic rhinitis (LAR) is characterized by chronic rhinitis with localized nasal allergic response to allergens in the absence of systemic immunoglobulin (IgE)-mediated disease assessed by skin prick test (SPT) or specific serum IgE level. Nasal provocation test (NPT) is the gold standard for the diagnosis of LAR. Nasal eosinophilia is a known inflammatory marker in allergic rhinitis. We hypothesized that nasal eosinophilia can be used as a screening tool for LAR.

Objective

To determine the applicability of nasal eosinophilia as a diagnostic tool for LAR.

Methods

Forty-eight perennial nonallergic rhinitis (NAR) patients with SPT negative were recruited. Nasal cytology analysis was performed. NPTs with 3 allergens (mixed mites, mixed cockroaches, and Bermuda grass) were performed to diagnose LAR. Nasal symptoms combined with nasal patency were used to determine the results of NPT. The sensitivity, specificity, positive predictive value, and negative predictive value of nasal eosinophilia as a diagnostic tool of LAR were calculated.

Results

LAR was diagnosed in 41.6% of the NAR patients. Nasal eosinophilia was found in 58% of the NAR patients. The sensitivity of nasal eosinophilia for diagnosing LAR was 80%, the specificity was 57.14%, the positive predictive value was 57.14%, and the negative predictive value was 80%. The most common allergen of LAR was mixed mites.

Conclusion

Nasal eosinophilia on nasal cytology was a good screening tool for diagnosing LAR because of its high sensitivity and simplicity of the procedure. Unfortunately, the low specificity of nasal eosinophilia makes the NPT necessary for confirmation of LAR.
Explaining the end of Spanish exceptionalism and electoral support for Vox
Authors: Turnbull-Dugarte Stuart J.
Published: May 2019

The 2018 regional elections in Andalucía marked the end of Spain’s exceptional status as a country with a party system free from the radical right. The electoral success of the radical right-wing challenger, Vox, who gained 11% of the vote and 12 seats in the regional parliament, brought this exceptionalism to an end. This paper analyses the individual-level determinants that explain the electoral success of Vox and the emergence of the radical right within the Spanish party system. The results indicate that concerns over devolution, likely engendered by the Catalan separatist crisis, predominantly explain voters’ preferences for the right-wing challenger. This is true both amongst the general electorate as well as amongst the former voters of other right-wing parties. Significantly, against popular assumptions and empirical observations explaining the rise of radical right-wing parties across much of Western Europe, the results display no empirical link between immigration and electoral support for Vox.
Assessing Patients’ Perception of Health Care Service Quality Offered by COHSASA-Accredited Hospitals in Nigeria
Authors: Mahmoud Ali Bassam , Ekwere Theresa , Fuxman Leonora , Meero Abdelrhman Ahmad
Published: May 2019

Service quality in health care institutions is an emerging phenomenon, and many hospitals are concerned about providing quality service to their patients based on information obtained by the patient’s perceptions of service quality. First, we aimed to determine patients’ perception of service quality offered at Council for Health Service Accreditation of Southern Africa (COHSASA)–accredited private hospitals in Nigeria. And that included reexamining the dimensionality of SERVQUAL (the test tool) based on our sample data. Second, we aimed to find out whether there are any existing gaps between patients’ expectation and perception of the service quality. Third, this research is an attempt to test the perceived quality effects on patients’ satisfaction and repurchase intentions toward health services. Quantitative research was conducted via self-administered questionnaires to patients who attended a randomly selected COHSASA-accredited private hospital in Nigeria and analyze their data using a variety of quantitative procedures including structural equation modeling, factor analyses, and paired-samples t tests. A systematic sampling method was used, and a total of 228 questionnaires were used for the final analyses. SERVQUAL was found to be a three-factor variate comprising the following: tangibility, reliability, and sensitivity. Our results concluded that perceived quality was significantly lower than expected quality despite being accompanied with positive levels of satisfaction and repurchase intentions. Finally, patient’s satisfaction was found to fully transmit the indirect effects of two of the three factors, quality sensitivity and reliability, onto repurchase intentions, whereas tangibility does not exert indirect significant influences over repurchase intentions via patient satisfaction.
Anatomy of the Subscapularis: A Review
Authors: Kellam Patrick , Kahn Timothy , Tashjian Robert Z
Published: May 2019

The subscapularis is the largest and most powerful muscle of the rotator cuff. Occupying the vast majority of the subscapular fossa, it is the only internal rotator of the rotator cuff. The subscapularis innervation is classically taught as a dual innervation of 1 upper subscapular and 1 lower subscapular nerve arising from the posterior cord of the brachial plexus. However, there is a large amount of research that suggests there is significant variance in the innervation of the muscle from multiple upper subscapular nerves to multiple lower subscapular nerves arising from various portions of the plexus. Although one of the main functions of the subscapularis is to internally rotate the humerus, there is substantial evidence that displays its importance in glenohumeral stability as well. The insertion of the subscapularis is both tendinous as well as muscular. The more superior tendinous portion inserts on the lesser tuberosity while the more muscular portion inserts inferior to the less tuberosity. The medial to lateral spread of the insertion is quite variable ranging from only on the lesser tuberosity to merging with fibers from the supraspinatus. Understanding the anatomy of the subscapularis improves subscapularis management during shoulder arthroplasty including techniques for takedown, release, and repair.
The importance of cation–cation repulsion in the zircon–reidite phase transition and radiation-damaged zircon
Authors: Tokuda Makoto , Yoshiasa Akira , Kojitani Hiroshi , Hashimoto Saki , Uehara Seiichiro , Mashimo Tsutomu , Tobase Tsubasa , Akaogi Masaki
Published: May 2019

Single crystals of synthetic reidite and natural radiation-damaged zircon from Okueyama, Japan were investigated using X-ray diffraction. The pressure-induced zircon–reidite transition is described by the twisting and translations of SiO4 tetrahedra with disappearance of the SiO4–ZrO8 shared edges. The lattice of radiation-damaged zircons expands mainly from α-decays of radioactive elements such as U and Th. Although old radiation-damaged zircons show anomolous lattice distortion, young radiation-damaged zircons do not show such distortions. These distortions are caused by thermal recovery that suppresses the Si4+–Zr4+ repulsion between the SiO4 tetrahedron and ZrO8 dodecahedron. These changes in structure can be understood by considering the cation–cation repulsion between the SiO4–ZrO8 shared edges.
RETRACTED ARTICLE: Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway
Authors: Zhang Xiaoli , Li Fei , Cui Yeqing , Liu Shuang , Sun Haichen
Published: May 2019

Background

Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined whether differential modification of Mst1 and Yap could further suppress thyroid carcinoma progression. The aim of our study was to explore the antiapoptotic effects exerted by combined Mst1 overexpression and Yap knockdown in thyroid carcinoma MDA-T32 cells in vitro.

Methods

Mst1 adenovirus and Yap shRNA were transfected into MDA-T32 cells to overexpress Mst1 and inhibit Yap, respectively. Cell viability and death were determined via an MTT assay, a TUNEL assay and western blotting. Mitochondrial function, mitochondrial fission and pathway studies were performed via western blotting and immunofluorescence.

Results

The results of our study showed that combined Mst1 overexpression and Yap knockdown further augmented MDA-T32 cell death by mediating mitochondrial damage. In addition, cancer cell migration and proliferation were suppressed by combined Mst1 overexpression and Yap knockdown. At the molecular level, mitochondrial membrane potential, ATP production, respiratory function, and caspase-9-related apoptosis were activated by combined Mst1 overexpression and Yap knockdown. Further, we found that fatal mitochondrial fission was augmented by combined Mst1 overexpression and Yap knockdown in a manner dependent on the JNK-MIEF1 pathway. Inhibition of JNK-MIEF1 pathway activity abolished the proapoptotic effects exerted by Mst1/Yap on MDA-T32 cells.

Conclusions

Taken together, our data suggest that Mst1 activation and Yap inhibition coordinate to augment thyroid cancer cell death by controlling the JNK-MIEF1-mitochondria pathway, suggesting that differential regulation of the core Hippo pathway components is potentially a novel therapeutic tool for the treatment of thyroid cancer.
Lower limb vascular assessment techniques of podiatrists in the United Kingdom: a national survey
Authors: Tehan Peta Ellen , Fox Martin , Stewart Sarah , Matthews Susan , Chuter Vivienne Helaine
Published: May 2019

Background

Podiatric vascular assessment practices in the United Kingdom (UK) are currently unknown. This study aimed to describe the current practices for performing lower limb vascular assessments by podiatrists in the UK, and, to investigate the effect of practitioner characteristics, including education level and practice setting, on the choice of tests used for these assessments.

Methods

A cross‐sectional observational online survey of registered podiatrists in the UK was conducted using SurveyMonkey® between 1st of July and 5th of October 2018. Item content related to: practitioner characteristics, vascular testing methods, barriers to completing vascular assessment, interpretation of vascular assessment techniques, education provision and ongoing management and referral pathways. Descriptive statistics were performed, and multinomial logistic regression analyses were used to determine whether practitioner characteristics could predict the choice of vascular tests used.

Results

Five hundred and eighty five participants accessed the online survey. After drop‐outs and exclusions, 307 participants were included in the analyses. Comprehensive vascular assessments had most commonly been performed once (15.8%) or twice (10.4%) in the past week. The most common indicators for performing vascular assessment were symptoms of suspected claudication (89.3%), suspected rest pain (86.0%) and history of diabetes (85.3%). The most common barrier to performing vascular assessment was time constraints (52.4%). Doppler examination (72.3%) was the most frequently reported assessment type, with ankle‐brachial index (31.9%) and toe brachial index (5.9%) less frequently performed. There were variable interpretations of vascular test results. The most common topic for education was smoking cessation (69.5%). Most participants (72.2%) were confident in determining ongoing management, with the majority referring to the patient's general practitioner (67.6%). Practitioner characteristics did not predict the types of vascular tests performed.

Conclusion

The majority of vascular assessments currently performed by podiatrists in the UK are inconsistent with UK or international vascular guidelines and recommendations. Despite this, most podiatrists felt confident in diagnosing, referring and managing patients with peripheral arterial disease (PAD), however many felt they needed more education to feel confident to assist patients with PAD to manage their cardiovascular risk factors.
Subjective and objective vestibular changes that occur following paediatric cochlear implantation: Systematic review and meta-analysis
Authors: Yong Michael , Young Emily , Lea Jane , Foggin Hannah , Zaia Erica , Kozak Frederick K. , Westerberg Brian D.
Published: May 2019

Objective

Cochlear implantation can result in post-operative vestibular dysfunction of unknown clinical significance. The objective of this study was to characterize the presence, magnitude, and clinical significance of vestibular dysfunction that occurs after pediatric cochlear implantation.

Data sources

The databases Embase, Medline (OvidSP), and PubMed were used. Only articles published in English were included. Grey literature and unpublished sources were also reviewed.

Study selection

Articles published from 1980 until the present which documented pre-operative and post-operative vestibular testing on children under the age of 18 were used.

Data extraction

Parameters that were assessed included number of patients, pre- and post-operative vestibular-evoked myogenic potentials (VEMPs), head impulse testing (HIT), calorics, and posturography, timing of pre- and post-operative testing, symptomatology, and other demographic data such as etiology of the hearing loss.

Data synthesis

Ten articles were included. Relative risk values evaluating the effect of cochlear implantation on vestibular function were calculated for VEMPs and caloric testing due to the availability of published data. I2 values were calculated and 95% confidence intervals were reported. Separate analyses were conducted for each individual study and a pooled analysis was conducted to yield an overall relative risk. Assessment on risk of bias in individual studies and overall was performed.

Conclusion

Pediatric cochlear implantation is associated with a statistically significant decrease in VEMP responses post-operatively (RR 1.8, p < 0.001, I2 91.86, 95%CI 1.57–2.02). Similar results are not seen in caloric testing. Insufficient data is available for analysis of HIT and posturography. Further studies are necessary to determine the effect of cochlear implantation on objective vestibular measures post-operatively and whether any changes seen are clinically relevant in this population.
Source-side spatial wavefield gradients in land seismic exploration
Authors: Van Renterghem Cédéric , Schmelzbach Cédric , Sollberger David , Häusler Mauro , Robertsson Johan Olof Anders
Published: May 2019

The recording of seismic data using arrays of densely spaced receivers enables the estimation of the spatial gradient components of the wavefield, in addition to the acquisition of conventional translational motion. We have extended the concept of array-based receiver-side gradiometry to the source-side and investigated the potential of combining source- and receiver-side gradient estimates for land seismic exploration. The robustness of array-based gradient source formation is demonstrated with a field data reciprocity experiment. We apply a gradient-based elastic wavefield decomposition technique to small arrays of densely spaced vertically and horizontally oriented force sources and determine with synthetic and field data examples that the processing of data obtained from multicomponent source arrays allows us to simulate a composite source that theoretically only emits S-waves at all emergence angles. A promising application of the gradient-based S-wave source is downhole S-wave imaging. Finally, by combining source- and receiver-side gradient estimates, 49C seismic data can be obtained comprising three translational components, three rotational components, and one divergence component on the source and receiver side. This concept could have a significant potential to enhance the acquisition and processing of data from locally dense arrays in land seismic exploration.
Uncovering neurodevelopmental features in bipolar affective disorder
Authors: Valli Isabel , Fabbri Chiara , Young Allan H.
Published: May 2019

Schizophrenia and bipolar disorder are genetically related and their clinical features overlap. Schizophrenia is conceptualised as a neurodevelopmental disorder but the evidence for bipolar disorder is less clear. Cluster-analytic approaches reveal different cognitive profiles within bipolar disorder, possibly reflective of differing neurodevelopmental loads, which are also suggested by recent genetic and neuroimaging studies. Such studies suggest the potential utility of further clinical subcategories in bipolar disorder based on neurodevelopmental load.

Declaration of interest

None.
Stage II Differentiated Thyroid Cancer Is a High-Risk Disease in Patients <45/55 Years Old
Authors: Liu Zeming , Shen Xiaopei , Liu Rengyun , Zhu Guangwu , Huang Tao , Xing Mingzhao
Published: May 2019

Purpose

The mortality risk of stage II differentiated thyroid cancer (DTC) based on the American Joint Committee on Cancer (AJCC) staging system requires further investigation.

Methods

Retrospective study of DTC in the US Surveillance, Epidemiology, and End Results program for disease-specific mortality risk in various AJCC stages, with patient age stratification of stage II disease.

Results

Using AJCC staging system 6.0, hazard ratios (HRs) of mortality for stage II DTC in patients <45 yo and patients ≥45 yo and stages III, IVA, IVB, and IVC compared with stage I were 46.95, 4.95, 9.82, 57.37, 222.10, and 468.68, respectively, showing a robustly higher mortality risk in stage II disease in patients <45 yo than in older patients (P < 0.001), comparable with stage IVA (P = 0.482). Similar results were obtained with AJCC 7.0. With AJCC 8.0, HRs of mortality for stage II in patients <55 yo and patients ≥55 yo and stages III, IVA, and IVB compared with stage I were 75.16, 11.23, 69.45, 134.94, and 235.70, respectively, showing a robustly higher risk in stage II disease in patients <55 yo than in older patients (P < 0.001), comparable with stage III (P = 0.57). Kaplan-Meier survival curves displayed a sharp decline with stage II disease in patients <45/55 yo compared with older patients.

Conclusions

The mortality risk of stage II DTC was sharply differentiated at patient age 45/55 years, being robustly high in younger patients and comparable with stage III/IVA. This emphasizes the importance of considering age when managing stage II DTC and not treating it as a uniformly low-risk disease.
Sesamoid malalignment in hallux valgus: Radiographic and MRI measurements and their correlation with internal derangement findings of the first metatarsophalangeal joint
Authors: Skweres Justin , Chhabra Avneesh , Hummel Jed , Heineman Nathan , Dessouky Riham , Xi Yin , Zhang Lihua , Wukich Dane
Published: May 2019

Objective:

Sesamoid displacement (SD) and rotation are important components in the preoperative assessment of hallux valgus (HV). To date, Inter reader reliability (IRR) of SD on X-rays and MRI, correlations with hallux valgus angle (HVA), and qualitative changes of the hallux-sesamoid complex (HSC) on MRI have not been studied. The aim of this study was to correlate sesamoid malalignment with HV severity and findings of internal joint derangement.

Methods:

Two readers analyzed a series of 56 consecutive patients who had X-rays and MRI performed on the same foot within 3 months of each other. Multiple measures of SD on X-rays and MRI and the sesamoid rotation angle (SRA) on MRI were assessed and correlated with HVA and various qualitative features at the HSC including cartilage, plantar plate, and collateral ligament abnormalities.

Results:

We found excellent IRR (ICC = 0.79 – 0.99) for SRA on MR, but poor IRR for lateral sesamoid displacement (LDS) and tibial sesamoid position (TSP) scales on both modalities. Good IRR was also seen for morphologic abnormalities of HSC. The absolute value of the SRA on MR positively correlated with HVA ( p < 0.0001). LDS and TSP on both modalities lacked a significant correlation with HVA ( p > 0.05). No correlation was found between any measure of SD or rotation with HSC morphologic changes ( p > 0.05).

Conclusion:

Among different measures of sesamoid malalignment, sesamoid rotation angle measured on MRI can be used to judge the severity of HV; however, it does not correlate with qualitative morphologic abnormalities of the HSC.

Advances in knowledge:

The MRI measurement of SRA is a better indicator of sesamoid displacement relative to the HSC than standard AP radiographic measures of non-rotational sesamoid displacement; however, it should not be used to predict qualitative morphologic abnormalities of the HSC.
Educação, memes e a categoria trabalho
Authors: Orsini Eddie Francisco Manoel Ferreira
Published: May 2019

Neste momento de crise da Educação, em que a realidade da Educação nos Colégios Estaduais da rede regular é extremamente dura, pretende-se investigar o uso de memes e outros elementos gráficos como recurso didático neste ambiente de dificuldades e desafios. Tenta-se construir um modus operandi para o uso da imagem (tão presente na sociedade), mas sem que se perca a riqueza do conteúdo da disciplina. Usa-se a teoria e método de István Mészáros, mas com a presença de outros momentos do marxismo. Neste estudo, o ser humano é compreendido enquanto um complexo de complexos, a saber, trabalho, pensamento e linguagem; mas este axioma lukacsiano é reposicionado pela crítica de Mészáros ao capital e sua sociabilidade caracterizada pela “autoalienação”. Desta perspectiva, fica claro que a Educação não deixa de ser a maneira que o indivíduo tem de direcionar sua capacidade de trabalho sobre si mesmo e, claro, também às instituições que fazem parte deste processo. Desta maneira, alcançamos uma aproximação maior entre o universo do educando e o do educador, demonstrando a capacidade dos recursos gráficos como catalisadores do Ensino. No ambiente da pós-modernidade e da revolução informacional com sua fluidez desconcertante, a imagem revelou-se um excelente recurso; mas vimos que ela demanda também que o educador saiba fazer uso dela.
OS MEMES E O GOLPE
Authors: Nolasco-Silva Leonardo , Soares Maria da Conceição Silva , Lo Bianco Vittorio
Published: May 2019

O artigo sugere pensar os memes como discursos abertos e colaborativos, capazes de participar da narração da nossa história comum, sublinhando sua potência na criação do pensamento. Memes são discursos (imagens, vídeos, músicas e outras formas de comunicação) que viralizam na internet e despertam o desejo de atualização. Diferente do viral que se assenta basicamente no compartilhamento, o meme demanda ser modificado para se inserir em cada novo ato de compartilhar. Um meme é, pois, um discurso que se adequa aos contextos mais variados, exigindo de quem o compartilha um trabalho de atualização e ressignificação. O texto apresenta aspectos positivos e negativos da memética e aponta para o papel ativo dos usuários na manipulação da linguagem em tela. Reflete sobre a viabilidade de intercâmbios semânticos entre os memes e o fazer científico, indicando que, apesar da aparência de repetição os memes produzem diferença. Reconhece os memes como disparadores de práticas formativas e, para tanto, apresenta como recorte de pesquisa a produção de memes no bojo do golpe de 2016, no Brasil.
Embedding knowledge into non-medical prescribing education
Authors: Walls Elaine
Published: May 2019

This article focuses on the non-medical prescribing (NMP) module for community prescribers in a nurse education context. The module mainly attracts registered nurses (RNs) from community settings (such as health visiting, school nursing, district nursing and practice nursing), and is provided in higher education institutions (HEIs) as part of a specialist programme or a continuing workforce development module. The article discusses changes to the way the module was taught that can enhance student learning within the NMP module and facilitate wider success and confidence among community nurse prescribers. The move from Nursing and Midwifery Council standards for prescribing to a single competency framework from the Royal Pharmaceutical Society (RPS) has encouraged academics to revisit teaching strategies and consider an approach that offers wider student participation in learning. The use of technology-enhanced learning (TEL) in HEIs is part of national recommendations to improve the student experience and increase success.
Analysis of the organisational culture in two Croatian hospitals
Authors: Mrkonjić Ružica , Ristić Jadranka , Jambrović Igor , Rukavina Marina , Rašić Irena
Published: May 2019

Background:

organisational culture is the character of the environment of individual bodies. It consists of a set of values, norms and customs that govern the relations between people within it. Its elements are a mission or goals, organisational climate and a working atmosphere, which affect motivation, effectiveness and, ultimately, management style.

Aim:

this research aimed to determine which organisational culture is prevalent in hospitals, and which staff consider is the most desirable.

Methods:

the research was conducted in two hospitals in Zagreb—University Hospital Sveti Duh and University Hospital Dubrava. The Organizational Culture Assessment Instrument was administered to 87 nurses.

Results:

in both hospitals, a clan culture was prevalent, followed by a hierarchical culture, then a competitive culture. The adhocracy culture was the least common. Participants said a clan culture was the most desirable, then a hierarchical culture, followed by the adhocracy culture; the least desirable was a competitive culture. In Sveti Duh, a clan culture was predominant, while in Dubrava it was a hierarchical culture. The most desirable culture for staff of both hospitals is the clan culture, but it was more prevalent in Sveti Duh.

Conclusion:

in two Croatian university hospitals, according to staff, a clan organisational culture is the most common type and is also the most desirable.
Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold
Authors: Bülow Roman David , Boor Peter
Published: May 2019

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases (CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all other organs, is pathological deposition of extracellular matrix (ECM). Renal ECM is a complex network of collagens, elastin, and several glycoproteins and proteoglycans forming basal membranes and interstitial space. Several ECM functions beyond providing a scaffold and organ stability are being increasingly recognized, for example, in inflammation. ECM composition is determined by the function of each of the histological compartments of the kidney, that is, glomeruli, tubulo-interstitium, and vessels. Renal ECM is a dynamic structure undergoing remodeling, particularly during fibrosis. From a clinical perspective, ECM proteins are directly involved in several rare renal diseases and indirectly in CKD progression during renal fibrosis. ECM proteins could serve as specific non-invasive biomarkers of fibrosis and scaffolds in regenerative medicine. The gold standard and currently only specific means to measure renal fibrosis is renal biopsy, but new diagnostic approaches are appearing. Here, we discuss the localization, function, and remodeling of major renal ECM components in healthy and diseased, fibrotic kidneys and the potential use of ECM in diagnostics of renal fibrosis and in tissue engineering.
Reading the grand palimpsest of mixed reality
Authors: Adria Marco
Published: May 2019

By applying Marshall McLuhan’s tetrad, this article proposes and responds to the question, ‘[h]ow does mixed reality change and create social environments?’. Historical examples of media as tools and modes of experience are described and assessed in order to reveal traces of the old and the ancient found in mixed reality. These examples include the Palais de l’electricité of 1900 and the medieval palimpsest. The article concludes with the argument that mixed reality foretells a new age of consumption.
The pre-modern self in post-modern times: The rhetoric of privacy in the work of Walter J. Ong, S.J.1
Authors: De Palma Paul
Published: May 2019

The Edward Snowden revelations of leaked National Security Agency documents in 2013 received considerable attention in the scholarly and popular media. More recently, Facebook and other social media sites have come under scrutiny for their role in the 2016 US elections. Surveys of attitudes consistently indicate that Americans fear identity theft and other problems arising from Internet use. Yet Americans consistently turn over their personal data to Google, Facebook and other large companies. An important 2015 study of Internet browsing habits showed that users, after an initial concern with privacy-enhancing technologies following the Snowden revelations, quickly returned to sports and celebrity gossip as loci of interest. This article teases out reasons for the apparent contradiction. It uses Walter J. Ong’s work, Norbert Elias’s study of manners, along with more recent scholarship on privacy, on the early book trade and on aspects of the early modern period to argue that the contemporary concept of privacy is historically contingent. Historical circumstances and the development of certain technologies encouraged the development of privacy and the self. Current circumstances and technologies are contributing to their decay. This article grows out of two preliminary addresses, one given at the 2016 meeting of the Media Ecology Association in Bologna and the other at a meeting of the Gonzaga University Socratic Club in 2018.
La lucha por la vida con xeroderma pigmentoso en la mansión de Los otros (2001)
Authors: Aguilar Vargas Esteban , Ayuso Díaz Víctor Manuel , Méndez Domínguez Nina Isabel
Published: May 2019

En la práctica médica nos encontramos día a día con pacientes que cursan con alergias o reacciones atípicas a elementos que se encuentran de manera común a su alrededor, pero en pocas ocasiones hemos de toparnos con reacciones tan severas como las que caracterizan a los individuos que padecen xenoderna pigmentoso. En la película Los otros (2001) de Alejandro Amenábar, los espectadores somos testigos de la lucha constante por la vida y por la salud que Grace enfrenta diariamente, una lucha contra el efecto de nada menos, que el sol mismo. La trama nos permite sentir la ansiedad, el estrés y la frustración que caracteriza a los habitantes de la mansión, ante una situación que finalmente, se resolvería de manera definitiva con el alto costo de su propia vida. Finalmente, la muerte resulta ser para los habitantes, una vía reveladora y liberadora que les permite recobrar la alegría y tranquilidad.
Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle
Authors: Purwanto Bambang , Wiyasihati Sundari Indah , Masyitha Putri Ayu , Wigati Kristanti Wanito , Irwadi Irfiansyah
Published: May 2019

Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.
A diagnosztikus mérési rendszer technológiai keretei: az eDia online platform
Authors: Molnár Gyöngyvér , Csapó Benő
Published: May 2019

A technológia fejlődése jelentős hatást gyakorol a tanulásra, az oktatásra, számos új lehetőséget kínál és várható, hogy a jövőben még jelentősebb változásokat hoz. Alkalmazása fontos kérdéseket vet fel az alapvetően tanár és diák személyes interakciójára épülő tanítási folyamatban. A pedagógusok számára az jelenti az egyik legnagyobb kihívást, miképpen tudják az alapvetően osztálykeretben folyó tevékenységet minden egyes diák számára hatékonnyá, személyre szabottá tenni. E folyamat alapvető feltétele a gyakori és pontos értékelés, annak ismerete, melyik diák hol tart a különböző fejlesztési területeken. Ezt a problémát oldja meg az eDia online értékelő rendszer, amely a személyre szóló fejlesztő munkát segítő eszközöket ad a pedagógus kezébe. A jelen tanulmány célja az eDia-rendszer technológiai kereteinek bemutatása. Áttekintjük az elektronikus tesztelés főbb mérföldköveit és az eDia-rendszer kidolgozásának szervezeti kereteit. Az eDia-rendszer felépítésének ismertetése során kiemelt figyelmet fordítunk a rendszer felhasználói felületének oktatási gyakorlatot segítő, a tesztelés minőségét javító főbb funkcióinak, tulajdonságainak bemutatására, mint például a változatos feladatszerkesztési, válaszadási és pontozási lehetőségekre, a személyre szóló visszajelentés felépítésére vagy a diákok fejlődésének nyomon követhetőségére. Külön kitérünk a rendszer tanórai integrációját segítő és támogató tanári tesztek modulban rejlő lehetőségekre, illetve a fejlesztések iskolai, pedagógiai munkát érintő hosszú távú céljaira.
Digitális kreativitás – a vizuális és informatikai kultúra szinergiája
Authors: Kárpáti Andrea , Nagy Angelika
Published: May 2019

A vizuális művészetek új műfajai a digitális kreativitás körébe tartoznak. Az immár általánosan elfogadott, az információs és kommunikációs technológiákat felhasználó képalkotó módszereket és innovatív megoldásokat tartalmazó új vizuális kultúra iskolai megismertetése fontos feladatunk, hiszen a fiatalok képalkotó közösségei ezt ma főként az iskolán kívül egymástól tanulják. Ebben az írásban röviden ismertetjük az Új Képkorszak képzőművészetének digitális műfajait, összefoglaljuk egy nemzetközi kutatás eredményeit a Vizuális Kultúra Tanuló Közösségekről és bemutatjuk a MoholyNagy Vizuális Modulok – a 21. század új képi nyelvének tanítása című pedagógiai program részeként megvalósuló, integrált vizuális és médiapedagógiát.
A digitális környezet következményei és lehetőségei kisgyermekkorban
Authors: Lénárd András
Published: May 2019

A digitális környezet kialakulása és változásai mélyreható társadalmi folyamatokat indukálnak (Kapitány és Kapitány, 2013). A digitális környezet nem kizárólag technológiai változások talaja, hanem a tudásról, tudásépítésről, annak módszertanáról vallott eddigi elképzeléseinket is alapjaiban érinti. A gyermekkorra a legtöbb forrás mint globális életkori szakaszra tekint, jórészt a mára már vitatható generációelméletekből (Prensky, 2001; Howe és Strauss, 2000) kiindulva. Érdemes azonban e szakaszt részekre bontva megvizsgálni, ugyanis az életkori sajátosságok függvényében a digitális környezeti hatások eltérően jelentkezhetnek az egyes fejlődési szakaszokban. E hatásokat semmiképpen nem hagyhatjuk figyelmen kívül, hiszen alapvető módszertani kategóriákat, megoldásokat befolyásolnak. Nagyrészt a digitális környezettel kapcsolatos laikus nézetek térnyerése miatt számos téveszme él a kisgyermekkori eszközhasználattal, digitális kompetenciákkal kapcsolatban. Ezek lebontása a helyes fejlesztési irányok meghatározásához elengedhetetlen. A tanulmány a kisgyermekkorra jellemző életkori sajátosságokból kiindulva mutat be néhány aspektust, mely a digitális környezeti hatások oktatásban történő figyelembe vételére nyújt példákat. Mindenképpen szükséges a kisgyermekkori oktatás módszertanának megújítása, melyben a digitális környezet változásai nemcsak feltételként, hanem elsősorban kiváló lehetőségként jelentkeznek. A jövő oktatásának kulcskérdése, hogy él-e, jól él-e ezekkel a lehetőségekkel egy olyan, a további fejlődés szempontjából döntő jelentőségű szakaszban, mint a kisgyermekkor.
Self Determination and Quality of Life: a Comparison of the Measurement Scales for Students with Intellectual Disabilities
Authors: Emanuela Zappella
Published: May 2019

Self-determination is a key concept to promote greater self-awareness in the subjects with disability, to build appropriate educational or professional projects and to evaluate the already active programs. Using PRISMA checklist, I selected articles from different databases (CINAHL, Medline, Psych INFO, Cochrane Library, ERIC, Scholar. The 9 evaluation measures identified are analyzed with respect to: choice of the points of view to be collected, domains, items and data collection methods. The results show that while some scales focus on autonomy, empowerment, self-realisation and self-regulation and others focus on knowledge, skills and abilities, attitudes and beliefs. Two instruments added also: opportunities and support. With respect to the choice of the points of view to be collected: in some cases the student’s opinion is collected but in other cases their point of view is integrated or replaced with that of teachers and parents. Only one tool is designed for all children and starts from the belief that self-determination is important for all people, including those with a disability. A third element of the analysis is the possibility of answering the questions posed by the various evaluation tools. A typical form is Likert scale while in other cases open questions are used. The analysis highlights two critical issues. The variety of definitions of self-determination is inevitably reflected in the choice of domains and items and therefore self-determination is only partially investigated. Secondly the opinion and people with disabilities are sometimes completed or replaced by that of third persons as parents and teachers. Starting from the analysis of existing instruments. the article closes with a reflection on the possibility of constructing a scale that considers all the aspects of self-determination offered in the literature (at the individual and environmental level) and collects the opinion of all the subjects involved in self-determination projects. This synthesis represents a first step in the construction of a possible universal scale starting from the analysis of the literature. A comparison would then be necessary with the students with intellectual disabilities, the family members and the other actors involved to understand which domains are really meaningful to them and to build indicators that correspond to the elements that are important to them. In this way we would have a tool capable of combining the point of view of literature with that of the people directly involved.
Palliative Gastrectomy and Survival in Patients With Metastatic Gastric Cancer: A Propensity Score–Matched Analysis of a Large Population-Based Study
Authors: Li Qin , Zou Jiahua , Jia Mingfang , Li Ping , Zhang Rui , Han Jianglong , Huang Kejie , Qiao Yunfeng , Xu Tangpeng , Peng Ruan , Song Qibin , Fu Zhenming
Published: May 2019

OBJECTIVES:

The role of palliative gastrectomy in the management of metastatic gastric cancer remains inadequately clarified.

METHODS:

We analyzed patients with metastatic gastric cancer enrolled in the Surveillance, Epidemiology, and End Results registry from January 2004 to December 2012. Propensity score (PS) analysis with 1:1 matching and the nearest neighbor matching method was performed to ensure well-balanced characteristics of the groups of patients who undergone gastrectomy and those without gastrectomy. Data were analyzed by Kaplan-Meier and Cox proportional hazards regression models to evaluate the overall survival and cancer-specific survival rates with corresponding 95% confidence intervals (CIs).

RESULTS:

In general, receiving any kind of gastrectomy was associated with an improvement in survival in the multivariate analyses (hazard ratio [HR]os = 0.64, 95% CI = 0.59–0.70, HRcss = 0.63, 95% CI = 0.57–0.68) and PS matching (PSM) analyses (HRos = 0.63, 95% CI = 0.56–0.70, HRcss = 0.62, 95% CI = 0.55–0.70). After PSM, palliative gastrectomy was found to be associated with remarkably improved survival for patients with stage M1 with only 1 metastasis but not associated with survival of patients with stage M1 with extensive metastasis (≥2 metastatic sites).

DISCUSSION:

The results obtained from the Surveillance, Epidemiology, and End Results database suggest that patients with metastatic gastric cancer might benefit from palliative gastrectomy on the basis of chemotherapy. However, a PSM cohort study of this kind still has a strong selection bias and cannot replace a properly conducted randomized controlled trial.
O Pibid e a dimensão afetiva: perspectivas do professor supervisor
Authors: Darroz Luiz Marcelo , Rosa Cleci Teresinha Werner da , Prediger Nathalia
Published: May 2019

Este artigo apresenta os resultados de uma pesquisa qualitativa realizada junto a um conjunto de supervisores do subprojeto Pibid/Física da Universidade de Passo Fundo, na qual se buscou identificar indícios de mudança na relação afetiva do professor com sua profissão. A hipótese que originou este trabalho é que a realidade docente apresenta dificuldades e os professores se encontram desmotivados com a profissão. A coleta de dados se deu a partir de entrevistas semiestruturadas com seis professores de escolas públicas que, na época dessa coleta, possuíam bolsas de supervisão do subprojeto pesquisado. A análise dos dados guiou-se pela Análise Textual Discursiva (ATD), que teve como categorias a priori cinco dimensões relacionadas ao domínio afetivo. Como resultado, percebeu-se que o Pibid influencia na relação afetiva do professor com sua profissão, uma vez que as falas dos supervisores permitiram identificar componentes dessa dimensão, que se fazem presentes na mudança afetiva após entrarem no programa.

PALAVRAS-CHAVE: Pibid/Física. Domínio afetivo. Afetividade. Supervisores.
Un nouveau témoin de l’Histoire des Sept Dormants d’Ephèse. Le manuscrit Cambridge Syr. Add. 2020. Texte et traduction
Authors: Afif Naïma
Published: May 2019

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Noms iraniens dans l’onomastique de la ville de Sardes
Authors: Bouzid-Adler Fabrice
Published: May 2019

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Les inscriptions funéraires antiques d’Antioche sur l’Oronte
Authors: Güven Evrim
Published: May 2019

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The Chief of Miners, Moses (Sinai 346, c. 1250 BCE)
Authors: Krahmalkov Charles R.
Published: May 2019

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La dernière oeuvre de Christian Knorr de Rosenroth : le Messias puer
Authors: Vileno Anna Maria , Wilkinson Robert J.
Published: May 2019

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