bluuebunny/crossref_metadata_2025 huggingface dataset:
SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication
Authors: Miyamoto Yoichi , Itoh Yumi , Suzuki Tatsuya , Tanaka Tomohisa , Sakai Yusuke , Koido Masaru , Hata Chiaki , Wang Cai-Xia , Otani Mayumi , Moriishi Kohji , Tachibana Taro , Kamatani Yoichiro , Yoneda Yoshihiro , Okamoto Toru , Oka Masahiro
Published: May 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF6 is an antagonist of interferon (IFN)-mediated antiviral signaling, achieved through the prevention of STAT1 nuclear localization. However, the exact mechanism through which ORF6 prevents STAT1 nuclear trafficking remains unclear. Herein, we demonstrate that ORF6 directly binds to STAT1 with or without IFN stimulation, resulting in the nuclear exclusion of STAT1. ORF6 also recognizes importin α subtypes with different modes, in particular, high affinity to importin α1 but a low affinity to importin α5. Although ORF6 potentially disrupts the importin α/importin β1-mediated nuclear transport, thereby suppressing the nuclear translocation of the other classical nuclear localization signal-containing cargo proteins, the inhibitory effect of ORF6 is modest when compared with that of STAT1. The results indicate that the drastic nuclear exclusion of STAT1 is attributed to the specific binding with ORF6, which is a distinct strategy for the importin α1-mediated pathway. Combined with the results from a newly-produced replicon system and a hamster model, we conclude that SARS-CoV-2 ORF6 acts as a virulence factor via regulation of nucleocytoplasmic trafficking to accelerate viral replication, resulting in disease progression.
Intrapopulation adaptive variance supports thermal tolerance in a reef-building coral
Authors: Drury Crawford , Bean Nina K. , Harris Casey I. , Hancock Joshua R. , Huckeba Joel , H Christian Martin , Roach Ty N. F. , Quinn Robert A. , Gates Ruth D.
Published: May 2022

Coral holobionts are multi-species assemblages, which adds significant complexity to genotype-phenotype connections underlying ecologically important traits like coral bleaching. Small scale heterogeneity in bleaching is ubiquitous in the absence of strong environmental gradients, which provides adaptive variance needed for the long-term persistence of coral reefs. We used RAD-seq, qPCR and LC-MS/MS metabolomics to characterize host genomic variation, symbiont community and biochemical correlates in two bleaching phenotypes of the vertically transmitting coral Montipora capitata. Phenotype was driven by symbiosis state and host genetic variance. We documented 5 gene ontologies that were significantly associated with both the binary bleaching phenotype and symbiont composition, representing functions that confer a phenotype via host-symbiont interactions. We bred these corals and show that symbiont communities were broadly conserved in bulk-crosses, resulting in significantly higher survivorship under temperature stress in juveniles, but not larvae, from tolerant parents. Using a select and re-sequence approach, we document numerous gene ontologies selected by heat stress, some of which (cell signaling, antioxidant activity, pH regulation) have unique selection dynamics in larvae from thermally tolerant parents. These data show that vertically transmitting corals may have an adaptive advantage under climate change if host and symbiont variance interact to influence bleaching phenotype.
IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy
Authors: Sharma Deepti , Bisen Shivantika , Kaur Geetika , Van Buren Eric C. , Rao Gadiparthi N. , Singh Nikhlesh K.
Published: May 2022

Pathological retinal neovascularization (NV) is a clinical manifestation of various proliferative retinopathies, and treatment of NV using anti-VEGF therapies is not selective, as it also impairs normal retinal vascular growth and function. Here, we show that genetic deletion or siRNA-mediated downregulation of IL-33 reduces pathological NV in a murine model of oxygen-induced retinopathy (OIR) with no effect on the normal retinal repair. Furthermore, our fluorescent activated cell sorting (FACS) data reveals that the increase in IL-33 expression is in endothelial cells (ECs) of the hypoxic retina and conditional genetic deletion of IL-33 in retinal ECs reduces pathological NV. In vitro studies using human retinal microvascular endothelial cells (HRMVECs) show that IL-33 induces sprouting angiogenesis and requires NFkappaB-mediated Jagged1 expression and Notch1 activation. Our data also suggest that IL-33 enhances de-ubiquitination and stabilization of Notch1 intracellular domain via its interaction with BRCA1-associated protein 1 (BAP1) and Numb in HRMVECs and a murine model of OIR.
Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins
Authors: Breyne Koen , Ughetto Stefano , Rufino-Ramos David , Mahjoum Shadi , Grandell Emily A. , de Almeida Luís P. , Breakefield Xandra O.
Published: May 2022

Cell membrane-based biovesicles (BVs) are important candidate drug delivery vehicles and comprise extracellular vesicles, virus-like particles, and lentiviral vectors. Here, we introduce a non-enzymatic assembly of purified BVs, supercharged proteins, and plasmid DNA called pDNA-scBVs. This multicomponent vehicle results from the interaction of negative sugar moieties on BVs and supercharged proteins that contain positively charged amino acids on their surface to enhance their affinity for pDNA. pDNA-scBVs were demonstrated to mediate floxed reporter activation in culture by delivering a Cre transgene. We introduced pDNA-scBVs containing both a CRE-encoding plasmid and a BV-packaged floxed reporter into the brains of Ai9 mice. Successful delivery of both payloads by pDNA-scBVs was confirmed with reporter signal in the striatal brain region. Overall, we developed a more efficient method to load isolated BVs with cargo that functionally modified recipient cells. Augmenting the natural properties of BVs opens avenues for adoptive extracellular interventions using therapeutic loaded cargo.
Retail prices of nutritious food rose more in countries with higher COVID-19 case counts
Authors: Bai Yan , Costlow Leah , Ebel Alissa , Laves Sarah , Ueda Yurika , Volin Natalie , Zamek Maya , Masters William A.
Published: May 2022

The COVID-19 pandemic has curtailed lives and livelihoods, leading to price spikes for some foods and declines for others. We compare monthly retail food prices in up to 181 countries from January 2019 to June 2021, test for differences over time and find that average prices rose significantly, especially for more nutritious food groups in countries with higher COVID-19 case counts. Analysis of retail prices by food group complements data on farm commodity prices and overall consumer price indexes, helping to guide policy for resilience and response to shocks.
Shoaling of abyssal ventilation in the Eastern Indian Sector of the Southern Ocean
Authors: Shimada Keishi , Kitade Yujiro , Aoki Shigeru , Mizobata Kohei , Cheng Lingqiao , Takahashi Kunio T. , Makabe Ryosuke , Kanda Jota , Odate Tsuneo
Published: May 2022

Antarctic Bottom Water formation, which ventilates the abyssal layers of the Southern Ocean, is an integral component of the global ocean meridional overturning circulation. Considering evident freshening and density decreases in the source waters, widespread warming in the Southern Ocean suggests a weakening in the Antarctic Bottom Water supply. We demonstrate that the weakening is robust based on water mass warming in the deep and abyssal layers of the Australian-Antarctic Basin, which remained after removing the southward shift effect of the Southern Antarctic Circumpolar Current Front. Moreover, a decrease in apparent oxygen utilisation and reduced warming in the intermediate density layer below Circumpolar Deep Water extended further from the Australian-Antarctic Basin to the South Australian Basin. We suggest that a concurrent weakening in the densest portion and strengthening in the less dense portion shape the multi-basin change in the meridional overturning circulation that originates from the Southern Ocean.
The role of ocean and atmospheric dynamics in the marine-based collapse of the last Eurasian Ice Sheet
Authors: Sejrup Hans Petter , Hjelstuen Berit Oline , Patton Henry , Esteves Mariana , Winsborrow Monica , Rasmussen Tine Lander , Andreassen Karin , Hubbard Alun
Published: May 2022

Information from former ice sheets may provide important context for understanding the response of today’s ice sheets to forcing mechanisms. Here we present a reconstruction of the last deglaciation of marine sectors of the Eurasian Ice Sheet, emphasising how the retreat of the Norwegian Channel and the Barents Sea ice streams led to separation of the British-Irish and Fennoscandian ice sheets at c. 18.700 and of the Kara-Barents Sea-Svalbard and Fennoscandian ice sheets between 16.000 and 15.000 years ago. Combined with ice sheet modelling and palaeoceanographic data, our reconstruction shows that the deglaciation, from a peak volume of 20 m of sea-level rise equivalent, was mainly driven by temperature forced surface mass balance in the south, and by Nordic Seas oceanic conditions in the north. Our results highlight the nonlinearity in the response of an ice sheet to forcing and the significance of ocean-ice-atmosphere dynamics in assessing the fate of contemporary ice sheets.
Introducing Candidatus Bathyanammoxibiaceae, a family of bacteria with the anammox potential present in both marine and terrestrial environments
Authors: Zhao Rui , Biddle Jennifer F , Jørgensen Steffen L
Published: May 2022

Anaerobic ammonium oxidation (Anammox) bacteria are a group of extraordinary bacteria exerting a major impact on the global nitrogen cycle. Their phylogenetic breadth and diversity, however, are not well constrained. Here we describe a new, deep-branching family in the order of Candidatus Brocadiales, Candidatus Bathyanammoxibiaceae, members of which have genes encoding the key enzymes of the anammox metabolism. In marine sediment cores from the Arctic Mid-Ocean Ridge (AMOR), the presence of Ca. Bathyanammoxibiaceae was confined within the nitrate-ammonium transition zones with the counter gradients of nitrate and ammonium, coinciding with the predicted occurrence of the anammox process. Ca. Bathyanammoxibiaceae genomes encode the core genetic machinery for the anammox metabolism, including hydrazine synthase for converting nitric oxide and ammonium to hydrazine, and hydrazine dehydrogenase for hydrazine oxidation to dinitrogen gas, and hydroxylamine oxidoreductase for nitrite reduction to nitric oxide. Their occurrences assessed by genomes and 16S rRNA gene sequencings surveys indicate that they are present in both marine and terrestrial environments. By introducing the anammox potential of Ca. Bathyanammoxibiaceae and charactering their ideal niche in marine sediments, our findings suggest that the diversity and abundance of anammox bacteria may be higher than previously thought, and provide important insights on cultivating them in the future to not only assess their biogeochemical impacts but also constrain the emergence and evolutionary history of this functional guild on Earth.
Estimating the COVID-19 infection fatality ratio accounting for seroreversion using statistical modelling
Authors: Brazeau Nicholas F. , Verity Robert , Jenks Sara , Fu Han , Whittaker Charles , Winskill Peter , Dorigatti Ilaria , Walker Patrick G. T. , Riley Steven , Schnekenberg Ricardo P. , Hoeltgebaum Henrique , Mellan Thomas A. , Mishra Swapnil , Unwin H. Juliette T. , Watson Oliver J. , Cucunubá Zulma M. , Baguelin Marc , Whittles Lilith , Bhatt Samir , Ghani Azra C. , Ferguson Neil M. , Okell Lucy C.
Published: May 2022

Background

The infection fatality ratio (IFR) is a key statistic for estimating the burden of coronavirus disease 2019 (COVID-19) and has been continuously debated throughout the COVID-19 pandemic. The age-specific IFR can be quantified using antibody surveys to estimate total infections, but requires consideration of delay-distributions from time from infection to seroconversion, time to death, and time to seroreversion (i.e. antibody waning) alongside serologic test sensitivity and specificity. Previous IFR estimates have not fully propagated uncertainty or accounted for these potential biases, particularly seroreversion.

Methods

We built a Bayesian statistical model that incorporates these factors and applied this model to simulated data and 10 serologic studies from different countries.

Results

We demonstrate that seroreversion becomes a crucial factor as time accrues but is less important during first-wave, short-term dynamics. We additionally show that disaggregating surveys by regions with higher versus lower disease burden can inform serologic test specificity estimates. The overall IFR in each setting was estimated at 0.49–2.53%.

Conclusion

We developed a robust statistical framework to account for full uncertainties in the parameters determining IFR. We provide code for others to apply these methods to further datasets and future epidemics.
Trajectory patterns of SARS-CoV-2 neutralising antibody response in convalescent COVID-19 patients
Authors: Wong Ngai Sze , Lee Shui Shan , Chan Denise P. C. , Li Timothy C. M. , Ho Tracy H. Y. , Luk Fion W. L. , Chow Kai Ming , Tso Eugene Y. K. , Yeoh Eng-Kiong , Wong Samuel Y. S. , Hui David S. C. , Lui Grace C. Y.
Published: May 2022

Background

The adaptive immune responses of COVID-19 patients contributes to virus clearance, restoration of health and protection from re-infection. The patterns of and the associated characteristics with longitudinal neutralising antibody (NAb) response following SARS-CoV-2 infection are important in their potential association with the population risks of re-infection.

Methods

This is a longitudinal study with blood samples and clinical data collected in adults aged 18 or above following diagnosis of SARS-CoV-2 infection. NAb levels were measured by the SARS-CoV-2 surrogate virus neutralisation test (sVNT). Anonymous clinical and laboratory data were matched with surveillance data for each subject for enabling analyses and applying latent class mixed models for trajectory delineation. Logistic regression models were performed to compare the characteristics between the identified classes.

Results

In 2020–2021, 368 convalescent patients in Hong Kong are tested for NAb. Their seroconversion occur within 3 months in 97% symptomatic patients, the level of which are maintained at 97% after 9 months. The NAb trajectories of 200 symptomatic patients are classified by the initial response and subsequent trend into high-persistent and waning classes in latent class mixed models. High-persistent (15.5%) class patients are older and most have chronic illnesses. Waning class patients (84.5%) are largely young adults who are mildly symptomatic including 2 who serorevert after 10 months.

Conclusions

Characteristic sub-class variabilities in clinical pattern are noted especially among patients with waning NAb. The heterogeneity of the NAb trajectory patterns and their clinical association can be important for informing vaccination strategy to prevent re-infection.
Synthesis of a Möbius carbon nanobelt
Authors: Segawa Yasutomo , Watanabe Tsugunori , Yamanoue Kotono , Kuwayama Motonobu , Watanabe Kosuke , Pirillo Jenny , Hijikata Yuh , Itami Kenichiro
Published: May 2022

Technologies for the creation of topological carbon nanostructures have greatly advanced synthetic organic chemistry and materials science. Although simple molecular nanocarbons with a belt topology have been constructed, analogous carbon nanobelts with a twist—more specifically, Möbius carbon nanobelts (MCNBs)—have not yet been synthesized owing to their high intrinsic strain. Here we report the synthesis, isolation and characterization of a MCNB. Calculations of strain energies suggest that large MCNBs are synthetically accessible. Designing a macrocyclic precursor with an odd number of repeat units led to a successful synthetic route via Z-selective Wittig reactions and nickel-mediated intramolecular homocoupling reactions, which yielded (25,25)MCNB over 14 steps. NMR spectroscopy and theoretical calculations reveal that the twist moiety of the Möbius band moves quickly around the MCNB molecule in solution. The topological chirality that originates from the Möbius structure was confirmed experimentally using chiral HPLC separation and circular dichroism spectroscopy.
Ice nucleating properties of airborne dust from an actively retreating glacier in Yukon, Canada
Authors: Xi Yu , Xu Cuishan , Downey Arnold , Stevens Robin , Bachelder Jill O. , King James , Hayes Patrick L. , Bertram Allan K.
Published: May 2022

Airborne dust from the Kaskawulsh Glacier outwash sediments contains effective INPs. The concentrations and properties of the INPs were investigated.
Quadrupole and multi-collector ICP-MS analysis of 226Ra in brain from a radium dial painter
Authors: Arbova D. L. , Tolmachev S. Y. , Brockman J. D.
Published: May 2022

Two ICP-MS methods were developed to measure the radiotoxic isotope 226Ra in brain tissues from a radium dial painter worker.
Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin
Authors: Leppkes Jakob , Dimos Nicole , Loll Bernhard , Hohmann Thomas , Dyrks Michael , Wieseke Ariane , Keller Bettina G. , Koksch Beate
Published: May 2022

Site-specific incorporation of fluorine into bovine pancreatic trypsin inhibitor (BPTI) through chemical protein synthesis, followed by investigations of influence of fluorine on inhibition properties towards serine protease chymotrypsin.
Dendrite-free lithium depositionviaa fumed silica interlayer as an electron inhibitor in all-solid-state batteries
Authors: Wang Liuyang , Li Zhuohua , Luo Jianchuan , Fan Hongyang , Zhao Ruirui
Published: May 2022

Nanosized-fumed silica acts as an electron inhibitor between the Li metal and garnet electrolyte to inhibit the dendrite formation.
Anodic dearomatization of 2-alkynylanilines for the synthesis of multi-functionalized indoles
Authors: Chen Zhuowen , He Qiuqin , Guo Hao , Fan Renhua
Published: May 2022

An anodic oxidative dearomatization of 2-alkynylaniline and its application for the synthesis of benzenoid ring multi-functionalized indoles is reported.
Synthesis of silica-stabilized Ag44 clusters aided by a designed mercaptosilane ligand
Authors: Yang Jinyu , Xie Shoudong , Zhang Hui , Xu Wenhao , Dong Angang , Tang Yun
Published: May 2022

The novel and precise design of both a microscopic ligand and macroscopic structure has been demonstrated to improve the stability and potential optical applications of Ag44 clusters.
Benzene and triazine-based porous organic polymers with azo, azoxy and azodioxy linkages: a computational study
Authors: Šutalo Petar , Pisačić Mateja , Biljan Ivana , Kodrin Ivan
Published: May 2022

Computational study of azoxy and azodioxy-based 2D layered structures revealed their potential for the selective binding of CO2 over N2.
The effect of annealing in carbon powders on the anisotropy of the thermoelectric properties of SrTiO3−δ single crystals on the (001) crystal plane
Authors: Ma Zhixin , Qi Yang , Bi Xiaoguo , Liu Xu-dong , Li Xiaodong , Li Ji-guang , Sun Xudong
Published: May 2022

The anisotropy of the thermoelectric properties of SrTiO3 on the (001) crystal plane is investigated by a combination of first-principles calculations and experimental results.
Toward size-dependent thermodynamics of nanoparticles from quantum chemical calculations of small atomic clusters: a case study of (B2O3)n
Authors: Loukhovitski Boris I. , Pelevkin Alexey V. , Sharipov Alexander S.
Published: May 2022

A method for obtaining temperature-dependent thermodynamics of arbitrary-sized particles from DFT calculations of the small clusters via extrapolation of the basic underlying properties rather than the thermodynamic functions themselves.
Photoinduced cascade cyclization of alkynes with NH4SCN: access to SCN-containing dibenzazepines or dioxodibenzothiazepines
Authors: Chen Shiliu , Yan Qinqin , Fan Jie , Gao Yongjun , Yang Xiulong , Li Lijun , Liu Zhongquan , Li Zejiang
Published: May 2022

Photoinduced tandem cyclization of alkynes with NH4SCN was developed for the synthesis of various SCN-containing seven-membered N-heterocycles.
Comprehensive comparison of sample preparation workflows for proteomics
Authors: Zheng Weimin , Yang Pengyuan , Sun Chuanyu , Zhang Yang
Published: May 2022

Exploring the optimal pretreatment protocol for proteomes: methodological workflow, protein characterization and the most comprehensive comparison.
Bimetallic Ni–Mo nitride@N-doped C as highly active and stable bifunctional electrocatalysts for full water splitting
Authors: Zhang Yu , Zhang Baiqing , Yin Zhuoxun , Ma Xinzhi , Zhou Yang
Published: May 2022

NiMoN-2 nanosheets were used as bifunctional catalysts and exhibited high total water decomposition activity. Only a cell voltage of 1.58 V was required to attain a current density of 10 mA cm−2.
Pd/CNT with controllable Pd particle size and hydrophilicity for improved direct synthesis efficiency of H2O2
Authors: You Huan , Fu Chengbing , Wang Meng , Yang Chunliang , Shi Yongyong , Pan Hongyan , Lin Qian
Published: May 2022

Comparison of Pd catalyst performance before and after N/O doping. Schematic diagram of anchoring Pd nanoparticles on the surface of N and O doped CNT.
Enhancing the capacity of supercapacitive swing adsorption CO2 capture by tuning charging protocols
Authors: Binford Trevor B. , Mapstone Grace , Temprano Israel , Forse Alexander C.
Published: May 2022

Electrochemical carbon dioxide capture by supercapacitors is found to depend strongly on charging protocols. Varying the charging polarity leads to increases in capture capacities and improved mechanistic understanding of the capture process.
Giant magnetoresistance and tunneling electroresistance in multiferroic tunnel junctions with 2D ferroelectrics
Authors: Chen Yancong , Tang Zhiyuan , Dai Minzhi , Luo Xin , Zheng Yue
Published: May 2022

Giant magnetoresistance and tunneling electroresistance are achieved in Ni/2L In2Se3/BN/Ni multiferroic tunnel junctions with eight resistance states.
On-resin Cα-functionalization of N-arylglycinyl peptides with boronic acids
Authors: Young Hailey A. , Proulx Caroline
Published: May 2022

A late-stage α-C–H functionalization reaction of resin-bound, electron-rich N-aryl peptides with boronic acid nucleophiles under mild conditions is reported.
Structure–property correlation of crosslinked domain hydrogels exhibiting thermoresponsive mechanical toughening and hybridization with photoluminescent carbon dots
Authors: Ida Shohei , Okuno Takahiro , Morimura Miki , Suzuki Kazumasa , Takeshita Hiroki , Oyama Masatoshi , Nakajima Keiji , Kanaoka Shokyoku
Published: May 2022

A smart gel material exhibiting a simultaneous change in mechanical properties and photoluminescence is developed.
Preparation of aminated porous polyacrylonitrile nanofibers as adsorbent for methyl orange removal
Authors: Wu Qinghua , Ling Xionghui , Huang Weigeng , Zeng Xianhua , Fan Longfei , Lin Junyu , Yu Wenhui , Yao Jiaen , Wen Wu
Published: May 2022

Amino functionalized porous polyacrylonitrile electrospun nanofibers were fabricated, which have good adsorption performance for MO in an acidic environment.
Polymerization kinetics of bicyclic olefins and mechanism with symmetrical ansa-metallocene catalysts associated with active center count: relationship between their activities and structure and activation path
Authors: Ali Amjad , Naveed Ahmad , Shehzad Khurram , Aziz Tariq , Rasheed Tahir , Moradian Jamile Mohammadi , Hassan Mobashar , Rahman Abdul , Zhiqiang Fan , Guo Li
Published: May 2022

Copolymerization of ethylene (E) with 5-vinyl-2-norbornene (VNB) catalyzed by ansa-metallocenes allows the precise control of essential polymeric properties such as comonomer incorporation, molecular weight (Mw), and polydispersity (Đ).
Light-responsive polyurethanes: classification of light-responsive moieties, light-responsive reactions, and their applications
Authors: Lam Ki Yan , Lee Choy Sin , Pichika Mallikarjuna Rao , Cheng Sit Foon , Hang Tan Rachel Yie
Published: May 2022

A comprehensive review of the advances of light-responsive PU in diverse ranges of medical and industrial applications. The review outlined the classes of light-responsive moieties, responsive mechanisms, and synthetic methods of light-responsive PU.
Acellular bioactivity and drug delivery of new strontium doped bioactive glasses prepared through a hydrothermal process
Authors: El Baakili Salwa , El Mabrouk Khalil , Bricha Meriame
Published: May 2022

This work aims to study the kinetics of apatite layer formation on the surface of strontium doped binary bioactive glasses (BG: 63S37C) prepared by a hydrothermal process and evaluate their potential for drug loading and release.
Combining multivariate curve resolution and lumped kinetic modelling for the analysis of lignin degradation by copper-catalyzed Fenton-like systems
Authors: Berkovic Andrea M. , Costante Mariana R. , García Einschlag Fernando S.
Published: May 2022

Efficient lignin degradation was achieved by dark cupro-Fenton treatment. Optimal conditions were assessed by using OED and SRM. Kinetic profiles obtained by MCR-ALS decomposition of UV-vis spectra allowed the development of a lumped kinetic model.
Quantum mechanical effects in acid–base chemistry
Authors: Zhang Xiaoliu , Zhou Shengmin , Leonik Fedra M. , Wang Lu , Kuroda Daniel G.
Published: May 2022

Acid-based theories do not consider the quantum mechanical nature of the acidic hydrogen shuttling potential. Here, it is demonstrated that this particularity is needed to explain the formation acid-base complex with a delocalized acidic hydrogen.
A flexible functional module to regulate ultraviolet optical nonlinearity for achieving a balance between a second-harmonic generation response and birefringence
Authors: Cao Liling , Tian Haotian , Lin Donghong , Lin Chensheng , Xu Feng , Han Yinglei , Yan Tao , Chen Jindong , Li Bingxuan , Ye Ning , Luo Min
Published: May 2022

The flexible (C3H2O4)2− groups were employed to design a new mixed alkali malonate KLi(C3H2O4)·H2O as an potential UV NLO crystal achieving the balance between strong SHG efficiency and moderate birefringence.
Design of hydrogel–microgel composites with tailored small molecule release profiles
Authors: Guo Siyuan , Wong Daniel , Wang Sifan , Gill Ravleen , Serpe Michael J.
Published: May 2022

Stimuli-responsive hydrogel-microgel composites (HMC) were prepared, and their controlled release properties investigated and release profiles correlated to the composite's chemical and physical properties.
Boosting the visible-light-driven photocatalytic antibacterial performance of MoS2 nanosheets by poly(3-(4-methyl-3′-thiophenoxy))propyltrimethylammonium chloride (PThM) modification
Authors: Xu Xiaoqing , Sun Yuansong , Zhang Manman , Zhao Rui , Zeng Shaohua , Xu Ying , Nie Wangyan , Zhou Yifeng , Chen Pengpeng
Published: May 2022

A schematic diagram of the synthesis of PTh/MoS2 and PThM/MoS2 and their use in the inactivation of E. coli.
Role of SWI/SNF chromatin remodeling genes in lung cancer development
Authors: Monterde Beatriz , Varela Ignacio
Published: May 2022

SWI/SNF family of chromatin remodeling complexes uses the energy of ATP to change the structure of DNA, playing key roles in DNA regulation and repair. It is estimated that up to 25% of all human cancers contain alterations in SWI/SNF, although the precise molecular mechanisms for their involvement in tumor progression are largely unknown. Despite the improvements achieved in the last decades on our knowledge of lung cancer molecular biology, it remains the major cause of cancer-related deaths worldwide and it is in urgent need for new therapeutic alternatives. We and others have described recurrent alterations in different SWI/SNF genes in nearly 20% of lung cancer patients, some of them with a significant association with worse prognosis, indicating an important role of SWI/SNF in this fatal disease. These alterations might be therapeutically exploited, as it has been shown in cellular and animal models with the use of EGFR inhibitors, DNA-damaging agents and several immunotherapy approaches. Therefore, a better knowledge of the molecular mechanisms regulated by SWI/SNF alterations in lung cancer might be translated into a therapeutic improvement of this frequently lethal disease. In this review, we summarize all the evidence of SWI/SNF alterations in lung cancer, the current knowledge about the potential mechanisms involved in their tumorigenic role, as well as the results that support a potential exploitation of these alterations to improve the treatment of lung cancer patients.
Performance analysis of RIS aided NOMA networks with hardware impairments
Authors: Lu Zhiping , Yue Xinwei , Chen Shuo , Ma Weiguo
Published: May 2022

Reconfigurable intelligent surface (RIS) has stimulated their potential applications for improving the performance of wireless communication networks. In this paper, the performance of RIS aided non‐orthogonal multiple access (NOMA) networks with hardware impairments over Rician fading channels is investigated. More specifically, the exact and asymptotic expressions of outage probability for a pair of users, that is, the nearby user n and distant user m are derived, where the imperfect successive interference cancellation (ipSIC) and perfect SIC (pSIC) are taken into consideration. According to the approximate analyses, the diversity orders of user n with ipSIC/pSIC and user m are obtained in the high signal‐to‐noise radio regime. It indicates that the diversity orders are in connection with reflecting elements and Rician factors except the channel ordering. The impact of these parameters on outage behaviors of RIS‐NOMA networks is also analysed. In addition, the system throughput of RIS‐NOMA networks with ipSIC/pSIC is surveyed in detail. Monte Carlo simulations are present to verify the correctness of theoretical analyses that: (1) The outage probability of user n with pSIC is superior to that of orthogonal user, while the outage probability of user m is inferior to that of orthogonal user and (2) as the number of reflecting elements and Rician factors increases, the outage behaviors of RIS‐NOMA networks are enhanced carefully.
Direction of arrival estimation under Class A modelled noise in shallow water using variational Bayesian inference method
Authors: Feng Xiao , Zhang Xuebo , Song Ruiping , Wang Junfeng , Sun Haixin , Esmaiel Hamada
Published: May 2022

The shallow water noise shows obvious impulsive property, which greatly degrades the direction of arrival (DOA) performance due to the conventional design concept based on the Gaussian assumption. In this paper, DOA estimator in presence of impulsive noise utilising variational Bayesian inference is proposed. The Middleton's Class A noise model is considered as a typical underwater noise model to analyse the performance of DOA estimation. The DOA estimation problem is modelled as the sparse signal recovery problem, and the hierarchical Bayesian learning framework is formulated by considering the common sparsity of signal and the element‐wise sparsity of the impulsive noise. The variational Bayesian inference realises the posterior estimation of signal and impulsive noise components. To mitigate the basis mismatches, the root sparse Bayesian learning method is applied to refine the steering vectors. Simulations verify the advantages of the proposed DOA method in terms of spatial resolution, root mean square error, accuracy, and robustness compared with the state‐of‐the‐art benchmarks in the presence of Middleton's Class A noise.
Three-dimensional extinction maps: Inverting inter-calibrated extinction catalogues
Authors: Vergely J. L. , Lallement R. , Cox N. L. J.
Published: May 2022

Context. Three-dimensional (3D) maps of the extinction density in the Milky Way can be built through the inversion of large catalogues of distance-extinction pairs for individual target stars. Considerable progress is currently achieved in this field through the Gaia mission. Available catalogues are based on various types of photometric or spectrophotometric information and on different techniques of extinction estimations.

Aims. The spatial resolution of the maps that can be achieved increases with the spatial density of the target stars, and, consequently, with the combination of input catalogues containing different target lists. However, this requires careful inter-calibration of the catalogues. Our aim is to develop methods of inter-comparison and inter-calibration of two different extinction catalogues.

Methods. The catalogue we used as reference for inter-calibration is a spectrophotometric catalogue. It provides a more accurate extinction than a purely photometric catalogue. In order to reduce the dimension of the problem, a principal component analysis was performed in (G, GB, GR, J, H, K) multi-colour space. The subspace constituted by the two first components was split into cells in which we estimated the deviations from the reference. The deviations were computed using all targets from the reference catalogue that were located at a short spatial distance of each secondary target. Corrections and filtering were deduced for each cell in the multi-colour space.

Results. We applied the inter-calibration to two very different extinction datasets: on the one hand, extinctions based on both spectroscopy and photometry, representing 6 million objects and serving as a reference, and, on the other hand, a catalogue of 35 million extinctions based on photometry of Gaia eDR3 and 2MASS. After calibration, the dispersion of the extinction among neighbouring points in the second catalogue is reduced, regardless of whether reference targets are present locally. Weak structures are then more apparent. The extinction of high Galactic latitude targets is significantly more tightly correlated with the dust emission measured by Planck, a property acquired from the first catalogue. A hierarchical inversion technique was applied to the two merged inter-calibrated catalogues to produce 3D extinction density maps corresponding to different volumes and maximum spatial resolution. The maximum resolution is 10 pc for a 3000 pc × 3000 pc × 800 pc volume around the Sun, and the maximum size of the maps is 10 kpc × 10 kpc × 800 pc for a resolution of 50 pc. The inclusion of the spectroscopic survey data increases the dynamic range of the extinction density, improves the accuracy of the maps, and allows the mapping to be extended to greater distances to better constrain the remarkable ≃ 2.5 kpc wide dust-free region in the second quadrant in particular, which now appears as a giant oval superbubble. Maps can be downloaded or used by means of on-line tools.
Bottleneck detection for discrete manufacturing system based on object-oriented colored petri nets and cloud simulation
Authors: Zhang Yongyang , Peng En’gao , Luo Zhenkun , Zeng Lianghua , Li Chun
Published: May 2022

To identify the bottleneck unit of discrete manufacturing system dynamically, an intelligent detection method of bottleneck (IDMOB) is proposed by combining object-oriented colored Petri nets (OOCPN) and cloud simulation. With the proposed method, the production cells of manufacturing system are abstracted as several Petri net sub-modules. And the messages are passed through mapping functions and message passing gates among Petri net modules. Then, the cloud simulation is created to simulate the real processing, and the production data and capacity function are plugged into the cloud to detect the bottleneck unit intelligently. Finally, the effectiveness of IDMOB method is applied and validated in a practical case study from the power transformer industry.
Resonances of a fractional-order biomedical model with time delay state feedback
Authors: Cui Zhoujin , Mao Zisen , Zhang Xiaorong
Published: May 2022

In the present paper, the primary resonance of a fractional-order Willis aneurysm system with time-delay state feedback control is studied. Using the multiple scale method, the amplitude and phase equations are obtained. The first order approximate solution is derived and the influence of time delay on resonance is studied. The concept of equivalent damping related to time-delay feedback is proposed, and the reasonable selection of feedback gain and time delay is discussed from the point of view of vibration control. The frequency response and external excitation response curves of the system are given. In order to test the stability of the system, bifurcation analysis is carried out. The obtained results are very useful in the clinical diagnosis and treatment of cerebral aneurysms.
A study of emotion setting based on event evolutionary graph-Take microblog users’ expression of emotions on news reports related to the Beijing Winter Olympics as an example
Authors: Yu Jinzheng , Zhu Ligu
Published: May 2022

With the prominence of the “emotion setting” function in media agenda setting, the sentiment bias of netizens has gradually become a noteworthy part of the communication of public opinion events. In this paper, we use the BERT model to analyze the sentiment of news headlines and netizens’ comments from January 2021 to July 2021, and extract news headlines and their relationships with the help of LTP to construct a theory map of news and comments for each month in Neo4j, and then explore the deep logic of netizens’ sentiment changes. The research results show that there is a correlation and lag between the emotional direction of Internet users and the emotional direction of media news reports in online public opinion dissemination. In addition, the public’s attention to information on international current affairs needs to be strengthened.
Conception of a global dispatching system for metauniverse in internet of everything sky-earth computing (i) beyond cloud computing
Authors: Li Zongcheng
Published: May 2022

In order to overcome the serious defects of information mechanism and promote the rationalization of resource allocation, this series of research proposes a hyper-cyber world computing mode which combines the traditional computing mode in various professional application fields with the modern computing mode in the field of information network technology (represented by distributed computing, grid computing, cloud computing and cluster computing), It can be called the Sky-Earth Computing (SEC). Here, “Sky (or Heaven)” metaphors the information world in the field of digital network technology, and “Earth” metaphors the real world in various professional application fields. Facing the ecosphere of metauniverse in Internet of everything, we propose to provide a customized global service dispatcher (GSD) and its enhanced version of the world-wise brain (WWB) with the user as the center. The global service dispatcher to be developed should have at least three functions: unified standard measurement system, supply-demand intelligent docking system, and integrated dispatching center system. Through the development and implementation of super metauniverse system engineering technology, let every user become the center of their own all-interconnected ecosphere (AIE)!
Construction and design of dynamic community management system for the elderly
Authors: Wang Rui , Zhou Chenghang , Deng Zhuofu
Published: May 2022

In view of that the current information management and service efficiency of most pension institutions is low and can not meet the needs of the elderly for professional care, combined with the convenience of the current application of the Internet, a dynamic community management system for the elderly was designed. This system is designed for managers and members in the community, and it is composed of five modules: membership management, housing management, check-in management, entertainment venue management and user management. In the realization of multiple sub-functions, the combination of file operation and structure array makes the structure clear and complete. At the same time, the realization of sub-functions directly applies the array function, reducing the number of lines of code inside the function, making the function more prominent and easier to identify.
Exploration on the teaching mode of public English based on learning link App
Authors: Zhou Yunhong
Published: May 2022

Under the condition of information technology, with the mobile teaching APPS help, it has become a new scenic spot in the classroom. The application of Chaoxing learning link in Higher Vocational English classroom provides a way to explore the online and offline English teaching mode. On the premise of investigating the mobile learning needs of higher vocational students, this study explores the online and offline public English teaching design, and provides a new perspective for the teaching strategies of English teaching.
Research on the Integration of the new generation of information technology into the curriculum system of business education
Authors: Dong Xiangli , Qin Zhangwei
Published: May 2022

With the development of the new generation of information technology, fintech, big data, block chain, cloud computing and other new information technology, as well as the emergence of new retail, new finance, intelligent manufacturing, digital management and other new formats. They pose new challenges to business education. Talent is the first resource. How to cultivate talents with new business technology and professional skills to adapt to the development of new business is an important issue in front of every business education institution, especially in the aspect of curriculum system. This paper discusses the research status, content, significance and thinking of the integration of the new generation of information technology into the curriculum system of business education, aiming to provide theoretical reference for the cultivation of composite applied business talents.
Inspection and treatment of four pipe supports and hangers of 350MW unit
Authors: Yuan Tangqing , Jian Liangliang , Li Jidong , Chen Yang , Jian Mingjian , Zhang Huakai
Published: May 2022

Based on the on-site cold and hot state inspection of the four pipelines of a 350MW unit in Shandong, combined with the review and calculation of stress, design and installation data, operation and maintenance records and other data, this paper formulates a practical adjustment plan and construction scheme, implements comprehensive adjustment and treatment of the four pipeline supports and hangers, basically restores the normal working state of the supports and hangers and pipelines, and ensures the safe operation of the unit.
Dynamic balance design and simulation verification of reed system of loom beating up mechanism
Authors: Wang Kang , Guo Sai
Published: May 2022

In order to reduce the vibration caused by the eccentricity of the reed system in the beating up mechanism of the loom, the centrifugal force generated by the eccentric reed system is decomposed into two parallel base planes, and a dynamic balance design scheme based on the principle of counterweight is established. Based on structural analysis and theoretical calculation, the reasonable balance weight mass, structure and assembly position are determined, and the reed system simulation model based on Adams/view platform is constructed. The correctness of the dynamic balance design scheme is verified by rigid body dynamics simulation and error analysis. The analysis results show that the centrifugal force simulation value F=347.008N, the design value F1=347.222N, and the error is 0.06%, which meets the requirements of mechanical accuracy design. It provides an important technical reference for dynamic balance design, vibration reduction and noise reduction of fixed axis rotation system.
Immobilizing metallocene by solid polymethylaluminoxane “sMAO” for slurry-phase ethylene-1-hexene copolymerization
Authors: Wu Chaofan , Ge Tengjie , Jiang Zeyu , Jiang Yanfeng , Zhang Qian , Li Jian
Published: May 2022

In the field of olefin catalytic polymerization, metallocene catalysts show higher activity than traditional Ziegler-Natta catalysts. In this study, benzoic acid catalyzed the controlled hydrolysis of trimethylaluminum (TMA) to methylaluminoxane (MAO). After pyrolysis, an insoluble form of solid polymethylaluminoxane (sMAO) was synthesized. The influence of synthesis conditions on the particle size and morphy was systematically explored. The synthetic sMAO is used as a carrier to support the metallocene catalyst, and the catalyst is applied to the ethylene/1-hexene copolymerization. The experimental results show that the activity can be as high as 12149.8 gPEꞏ(gcat)-1 when the slurry reaction is catalyzed in a 5L kettle.
A Verticality Adjustment Technology for AP1000 Refueling Machine Mast
Authors: Zuo Changdi , Dong Jianlei , Zhao Haidong , Xie Jun , Mu Di
Published: May 2022

The refueling machine is used to handle the nuclear fuel assembly in the nuclear island, and is used to transport fuel between the fuel upender basket and reactor vessel core. During Unit 1 of a nuclear power plant initial fuel loading, it was found that the inner mast operated with large friction, which caused frequent triggering of overload protection during fuel operation, and the refueling machine was difficult to be operated normally. According to the unique design characteristics of the inner mast of the AP1000 refueling machine, the verticality adjustment method of the mast of the AP1000 refueling machine is developed. By adjusting the verticality of the outer mast, the concentricity of the inner and the outer mast, the levelness of the equilibrium arm of the inner mast, and the gap between the guide roller of the outer mast and the inner mast, the problem of high friction in the operation of the inner mast is solved. At the same time, the verticality of the inner mast during operation is ensured. This method has been successfully applied in the first overhaul of a power plant. It can be used to guide the installation and adjustment of the refueling machine mast with similar structure.
Study on the Synthesis of Water-dispersible Acrylic Resin Containing Hydroxyl Group`
Authors: Jing Ma , Rong Mu , Lai Daowei , Li Huaming , Tao Yong , Fei Xiao , Zhou Chunyu , Sun Chufeng
Published: May 2022

Hydroxy acrylic resin is a long-chain polymer material formed by cleavage and recombination of double bonds of various acrylates and methacrylates under the action of initiators. Among them, MMA and BA provide the rigidity of the molecular chain and For flexibility, HEMA provides the hydroxyl groups required for cross-linking and curing, and MAA gives the resin water solubility. By rationally designing different monomer dosages, resin products with high gloss and high hardness are prepared, and through paint making experiments, the paint film Performance is tested.
Study on preparation and performance of additive flame retardant DOPO-HQ modified epoxy composite
Authors: Wang Chenghui , Wang Lele , Zhang Yingqiang
Published: May 2022

An additive flame retardant was prepared from DOPO-HQ. Fourier transform infrared spectroscopy (FT-IR) was used to analyze its chemical structure. It was added to the experimental formula to prepare EP composite material, and the limiting oxygen index experiment and thermogravimetric analysis experiment were carried out on the material, and the scanning electron microscope experiment was carried out on the residual carbon after combustion. The results show that the modified epoxy resin has a limiting oxygen index of 29.5%, and there is no droplet during combustion; thermogravimetric analysis experiments show that the temperature at which the thermal weight loss is 5%wt decreases, but the residual carbon rate increases. Scanning electron microscopy (SEM) test results show that carbon layer formed by the combustion products of epoxy resin is denser..