bluuebunny/crossref_metadata_2025 huggingface dataset:
A Wind Power Prediction Method Based on DE-BP Neural Network
Authors: Li Ning , Wang Yelin , Ma Wentao , Xiao Zihan , An Zhuoer
Published: February 2022

With the continuous increase of installed capacity of wind power, the influence of large-scale wind power integration on the power grid is becoming increasingly apparent. Ultra-short-term wind power prediction is conducive to the dispatching management of the power grid and improves the operating efficiency and economy of the power system. In order to overcome the intermittency and uncertainty of wind power generation, this article proposes the differential evolution–back propagation (DE-BP) algorithm to predict wind power and addresses such shortcomings of the BP neural network as its falling into local optimality and slow training speed when predicting. In this article, the DE algorithm is used to find the optimal value of the initial weight and threshold of the BP neural network, and the DE-BP neural network prediction model is obtained. According to the data of a wind farm in Northwest China, the short-term wind power is predicted. Compared with the application of the BP model in wind power prediction, the results show that the accuracy of the DE-BP algorithm is improved by about 5%; compared with the genetic algorithm–BP model, the prediction time is shortened by 23.1%.
Epigenetic Biomarkers Screening of Non-Coding RNA and DNA Methylation Based on Peripheral Blood Monocytes in Smokers
Authors: Huang Xiaowei , Wu Bian , Zhang Fangxue , Chen Fancheng , Zhang Yong , Guo Huizhi , Zhang Hongtao
Published: February 2022

This study aims to use bioinformatics methods to determine the epigenetic changes in microRNA expression and DNA methylation caused by cigarette smoking. The data of mRNA, miRNA expression, and methylation microarray were obtained from the GEO database to filter differentially expressed genes (DEGs), differentially expressed miRNAs (DEMs), and methylated CpG probes (DMPs) through the limma package. The R clusterProfile package was used for functional annotation and enrichment analysis. The protein-protein interaction (PPI) network was constructed by the String database and visualized in Cytoscape software. Starbase database was employed to predict lncRNA and CirRNA based on the sequence of miRNA, and to establish a regulatory network of ceRNA. By overlapping DEG and DEM, 107 down-miRNA-targeted up-regulated genes and 65 up-miRNA-target down-regulated genes were obtained, which were mainly enriched in autophagy signaling pathways and protein ubiquitination pathways, respectively. In addition, 324 genes with low methylation and high expression and 204 genes with high methylation and low expression were respectively related to the degeneration of the nervous system and the function of the cardiovascular system. Interestingly, 43 genes were up-regulated under the dual regulation of reduced miRNA and hypomethylation, while 14 genes were down-regulated under the dual regulation of increased miRNA and hypermethylation. Ten chemicals have been identified as putative therapeutic agents for pathological conditions caused by smoking. In addition, among these genes, HSPA4, GRB2, PRKCA, and BCL2L1 could play a fundamental role in related diseases caused by smoking and may be used as the biomarkers for precise diagnosis and targets for future therapies of smoking-related diseases.
Case Report: Durable Complete Response After Combined Immunotherapy Following Resection of Primary Tumor in a Gallbladder Cancer Patient With Distant Metastatic Lymph Nodes of Favorable Immune-Microenvironment
Authors: Yi Bin , Zhao Zhikun , Dong Hui , Yuan Lei , Wu Yingjun , Xu Yun , Jiang Xiaoqing , Sun Chao , Wu Dongfang , Xiao Yajie
Published: February 2022

Background

Metastatic gallbladder carcinoma (GBC) is one of the most aggressive malignancies. As GBC is usually diagnosed with distant metastases, only a few patients can receive R0 resection and the relapse rate remains high. Programmed cell death protein 1 (PD-1) blockade therapy has provided encouraging long-term outcomes in a subset of patients in many cancers. However, the data on efficacy of PD-1 blockade in GBC are very limited.

Case Presentation

We herein reported a stage IVB GBC patient with localized primary tumor and distant lymph node metastasis. Except for the unresectable multiple metastatic nodes including distant nodes, a complete resection of primary tumor en bloc with partial segment 4B+5 was performed. Tumor tissues of primary tumor and one metastatic lymph node were collected to perform whole-exome sequencing, RNA-seq, and immunohistochemistry. Low TMB (5.38 muts/Mb), low MSI (<20%), and negative PD-L1 expression (TC0) were observed in the primary tumor. Likewise, low TMB (5.44 muts/Mb), low MSI (<20%), and low PD-L1 expression (TC2) presented in the metastatic lymph node. Besides, low genetic intratumor heterogeneity exhibited between the primary and metastatic tumors in this patient. In contrast to the primary tumor, higher-level CD8+ T cell infiltration was revealed in the tumor microenvironment of the metastatic lymph node. Then, chemo-immunotherapy using S1 and anti-PD-1 antibody pembrolizumab was administrated as the first-line treatment for the residual metastatic nodes. Complete response was achieved after 7 courses and has lasted for 32 months up to present. Additionally, blood samples during treatment were further analyzed for immune repertoire sequencing, showing that several T cell receptor clones in metastatic lymph node were predominant in blood during the combined anti-PD-1 treatment.

Conclusions

Chemo-immunotherapy may provide a potential curative option for the lymph node metastases of gallbladder cancer. The low intratumor heterogeneity and high level of infiltrating CD8+ T-cells in metastatic node might be indispensable to the durable complete response in this patient.
MEDUSA: Multi-Scale Encoder-Decoder Self-Attention Deep Neural Network Architecture for Medical Image Analysis
Authors: Aboutalebi Hossein , Pavlova Maya , Gunraj Hayden , Shafiee Mohammad Javad , Sabri Ali , Alaref Amer , Wong Alexander
Published: February 2022

Medical image analysis continues to hold interesting challenges given the subtle characteristics of certain diseases and the significant overlap in appearance between diseases. In this study, we explore the concept of self-attention for tackling such subtleties in and between diseases. To this end, we introduce, a multi-scale encoder-decoder self-attention (MEDUSA) mechanism tailored for medical image analysis. While self-attention deep convolutional neural network architectures in existing literature center around the notion of multiple isolated lightweight attention mechanisms with limited individual capacities being incorporated at different points in the network architecture, MEDUSA takes a significant departure from this notion by possessing a single, unified self-attention mechanism with significantly higher capacity with multiple attention heads feeding into different scales in the network architecture. To the best of the authors' knowledge, this is the first “single body, multi-scale heads” realization of self-attention and enables explicit global context among selective attention at different levels of representational abstractions while still enabling differing local attention context at individual levels of abstractions. With MEDUSA, we obtain state-of-the-art performance on multiple challenging medical image analysis benchmarks including COVIDx, Radiological Society of North America (RSNA) RICORD, and RSNA Pneumonia Challenge when compared to previous work. Our MEDUSA model is publicly available.
Comparative Genomics and Characterization of SARS-CoV-2 P.1 (Gamma) Variant of Concern From Amazonas, Brazil
Authors: Zimerman Ricardo Ariel , Ferrareze Patrícia Aline Gröhs , Cadegiani Flavio Adsuara , Wambier Carlos Gustavo , Fonseca Daniel do Nascimento , de Souza Andrea Roberto , Goren Andy , Rotta Liane Nanci , Ren Zhihua , Thompson Claudia Elizabeth
Published: February 2022

Background

P.1 lineage (Gamma) was first described in the State of Amazonas, northern Brazil, in the end of 2020, and has emerged as a very important variant of concern (VOC) of SARS-CoV-2 worldwide. P.1 has been linked to increased infectivity, higher mortality, and immune evasion, leading to reinfections and potentially reduced efficacy of vaccines and neutralizing antibodies.

Methods

The samples of 276 patients from the State of Amazonas were sent to a central referral laboratory for sequencing by gold standard techniques, through Illumina MiSeq platform. Both global and regional phylogenetic analyses of the successfully sequenced genomes were conducted through maximum likelihood method. Multiple alignments were obtained including previously obtained unique human SARS-CoV-2 sequences. The evolutionary histories of spike and non-structural proteins from ORF1a of northern genomes were described and their molecular evolution was analyzed for detection of positive (FUBAR, FEL, and MEME) and negative (FEL and SLAC) selective pressures. To further evaluate the possible pathways of evolution leading to the emergence of P.1, we performed specific analysis for copy-choice recombination events. A global phylogenomic analysis with subsampled P.1 and B.1.1.28 genomes was applied to evaluate the relationship among samples.

Results

Forty-four samples from the State of Amazonas were successfully sequenced and confirmed as P.1 (Gamma) lineage. In addition to previously described P.1 characteristic mutations, we find evidence of continuous diversification of SARS-CoV-2, as rare and previously unseen P.1 mutations were detected in spike and non-structural protein from ORF1a. No evidence of recombination was found. Several sites were demonstrated to be under positive and negative selection, with various mutations identified mostly in P.1 lineage. According to the Pango assignment, phylogenomic analyses indicate all samples as belonging to the P.1 lineage.

Conclusion

P.1 has shown continuous evolution after its emergence. The lack of clear evidence for recombination and the positive selection demonstrated for several sites suggest that this lineage emergence resulted mainly from strong evolutionary forces and progressive accumulation of a favorable signature set of mutations.
The Role of Awareness on Motor-Sensory Temporal Recalibration
Authors: Bubna Mikaela , Lam Melanie Y. , Cressman Erin K.
Published: February 2022

Temporal recalibration (TR) may arise to realign asynchronous stimuli after exposure to a short, constant delay between voluntary movement and sensory stimulus. The objective of this study was to determine if awareness of the temporal lag between a motor response (i.e., a keypress) and a sensory event (i.e., a visual flash) is necessary for TR to occur. We further investigated whether manipulating the required motor and perceptual judgment tasks modified the influence of awareness on TR. Participants (n = 48) were randomly divided between two groups (Group 1: Aware and Group 2: Unaware). The Aware group was told of the temporal lag between their keypress and visual flash at the beginning of the experiment, whereas the Unaware group was not. All participants completed eight blocks of trials, in which the motor task (single or repetitive tap), perceptual judgment task (judging the temporal order of the keypress in relation to the visual flash or judging whether the two stimuli were simultaneous or not), and fixed temporal lag between keypress and visual flash (0 or 100 ms) varied. TR was determined by comparing judgments between corresponding blocks of trials in which the temporal lag was 0 or 100 ms. Results revealed that both the Aware and Unaware groups demonstrated a similar magnitude of TR across all motor and perceptual judgment tasks, such that the magnitude of TR did not vary between Aware and Unaware participants. These results suggest that awareness of a temporal lag does not influence the magnitude of TR achieved and that motor and perceptual judgment task demands do not modulate the influence of awareness on TR.
CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma
Authors: Qiu Lin , Zhou Rui , Luo Ziyan , Wu Jiangxue , Jiang Hua
Published: February 2022

Neuroblastoma (NB) is a devastating malignancy threatening children’s health, and amplification of MYCN is associated with treatment failure and a poor outcome. Here, we aimed to demonstrate the role of cell division cycle 27 (CDC27), an important core subunit of the anaphase-promoting complex, and its clinical significance in NB patients. In functional assays, we illustrated that CDC27 promoted the cell growth, metastasis and sphere-formation ability of NB cells both in vitro and in vivo. To further understand the potential mechanism, SK-N-SH cells were transfected with CDC27 siRNA, and RNA-sequencing was performed. The results revealed that downregulation of CDC27 led to markedly reduced expression of ODC1, which is a well-established direct target of MYCN. Subsequently, we further illustrated that suppression of ODC1 significantly attenuated the promotion effect of CDC27 on the proliferation, metastasis, and sphere-formation ability of NB cells, hinting that CDC27 exerted its biological behavior in NB at least partly in an ODC1-dependent manner. In addition, CDC27 rendered cells more vulnerable to ferroptosis, while knockdown of ODC1 markedly reversed the pro-ferroptotic effect of CDC27. Collectively, our data is the first to report that the CDC27/ODC1 axis promotes tumorigenesis and acts as a positive regulator of ferroptosis in NB, highlighting that CDC27 may represent a novel therapeutic strategy and prognostic biomarker in neuroblastoma.
Macrophages and Metabolic Reprograming in the Tumor Microenvironment
Authors: Liu Jin , Gao Mingwei , Yang Zhou , Zhao Yidan , Guo Kun , Sun Binwen , Gao Zhenming , Wang Liming
Published: February 2022

Due to the emergence of traditional drug resistance in tumor treatment, the anti-cancer therapies are facing multiple challenges. Immunotherapy, as a new and universal treatment, has been gradually concerned. The macrophages, as an important part of the immune system, play an important role in it. Many studies have shown that immune state is essential in cancer progression and prognosis, rebuilding the architecture and functional orientation of the tumor region. Most tumors are complex ecosystems that change temporally and spatially under the pressure of proliferation, apoptosis, and extension of every cell in the microenvironment. Here, we review how macrophages states can be dynamically altered in different metabolic states and we also focus on the formation of immune exhaustion. Finally, we look forward to the explorations of clinical treatment for immune metabolism process.
Role of Radiation Based Conditioning Regimens in Patients With High-Risk AML Undergoing Allogenic Transplantation in Remission or Active Disease and Mechanisms of Post-Transplant Relapse
Authors: Salhotra Amandeep , Stein Anthony Selwyn
Published: February 2022

In the two decades there has been a consistent improvement in the clinical outcomes of patients diagnosed with acute leukemia undergoing allogenic stem cell transplantation. These improvements have been made possible by advancements in supportive care practices, more precise risk stratification of leukemia patients by genetic testing at diagnosis, accurate disease assessment by measurable residual disease (MRD) in pretransplant marrow and attempts to clear residual disease clones prior to transplant. Availability of targeted therapies, immunotherapies, and approval of novel drug combinations with BCL-2 inhibitors has also improved remission rates for patients who are undergoing transplant. For patients who are unable to achieve a morphologic or MRD- remission prior to transplant, the risk of relapse post-transplant remains high. Total body irradiation (TBI) based intensification of transplant conditioning may be able to overcome risk of increased relapse rate in this clinical setting by improving clearance of leukemic clones. However, in the past increased nonrelapse mortality (NRM) associated with escalation of conditioning intensity has neutralized any potential benefit of decreasing relapse rate in HCT patient resulting in no significant improvement in overall survival. In this review we discuss incorporation of newer radiation techniques such as total marrow irradiation (TMI) to safely deliver targeted doses of radiation at higher doses to improve outcomes of patients with active leukemia. We also discuss the mechanisms associated with leukemia relapse and treatment options available in post allo-HCT relapse setting despite use of intensified conditioning regimens.
Optimization of Cervical Cancer Screening: A Stacking-Integrated Machine Learning Algorithm Based on Demographic, Behavioral, and Clinical Factors
Authors: Sun Lin , Yang Lingping , Liu Xiyao , Tang Lan , Zeng Qi , Gao Yuwen , Chen Qian , Liu Zhaohai , Peng Bin
Published: February 2022

Purpose

The purpose is to accurately identify women at high risk of developing cervical cancer so as to optimize cervical screening strategies and make better use of medical resources. However, the predictive models currently in use require clinical physiological and biochemical indicators, resulting in a smaller scope of application. Stacking-integrated machine learning (SIML) is an advanced machine learning technique that combined multiple learning algorithms to improve predictive performance. This study aimed to develop a stacking-integrated model that can be used to identify women at high risk of developing cervical cancer based on their demographic, behavioral, and historical clinical factors.

Methods

The data of 858 women screened for cervical cancer at a Venezuelan Hospital were used to develop the SIML algorithm. The screening data were randomly split into training data (80%) that were used to develop the algorithm and testing data (20%) that were used to validate the accuracy of the algorithms. The random forest (RF) model and univariate logistic regression were used to identify predictive features for developing cervical cancer. Twelve well-known ML algorithms were selected, and their performances in predicting cervical cancer were compared. A correlation coefficient matrix was used to cluster the models based on their performance. The SIML was then developed using the best-performing techniques. The sensitivity, specificity, and area under the curve (AUC) of all models were calculated.

Results

The RF model identified 18 features predictive of developing cervical cancer. The use of hormonal contraceptives was considered as the most important risk factor, followed by the number of pregnancies, years of smoking, and the number of sexual partners. The SIML algorithm had the best overall performance when compared with other methods and reached an AUC, sensitivity, and specificity of 0.877, 81.8%, and 81.9%, respectively.

Conclusion

This study shows that SIML can be used to accurately identify women at high risk of developing cervical cancer. This model could be used to personalize the screening program by optimizing the screening interval and care plan in high- and low-risk patients based on their demographics, behavioral patterns, and clinical data.
Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients With Operated Oral Cavity Cancer: A Retrospective Study
Authors: Tsai Yao-Te , Fang Ku-Hao , Hsu Cheng-Ming , Lai Chia-Hsuan , Chang Sheng-Wei , Huang Ethan I. , Tsai Ming-Shao , Chang Geng-He , Luan Chih-Wei
Published: February 2022

Aim

We probed the prognostic value of the preoperative high-sensitivity modified Glasgow prognostic score (HS-mGPS), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) for patients with oral cavity squamous cell carcinoma (OSCC) to identify patients with the highest risk of having poor survival outcomes.

Materials and Methods

We executed a retrospective assessment of the records of 303 patients with OSCC who had been subjected to curative surgery between January 2008 and December 2017. The HS-mGPS was categorized using C-reactive protein and albumin thresholds of 3 mg/L and 35 g/L, respectively. Moreover, receiver operating characteristic curve analyses were executed to find out the optimal PLR and NLR cutoffs. We plotted survival curves and compared them through the use of the Kaplan–Meier method and log-rank test, respectively. Through a Cox proportional hazard model, we identified prognostic variables. We also plotted a nomogram comprising the HS-mGPS and clinicopathological factors and assessed its performance with the concordance index.

Results

The PLR and NLR cutoffs were 119.34 and 4.51, respectively. We noted an HS-mGPS of 1−2 to be associated with a shorter median overall survival (OS) and disease-fee survival (DFS) compared with an HS-mGPS of 0. Multivariate analysis revealed that an HS-mGPS of 1−2 and an NLR of ≥4.51 were independent risk factors related to poor OS and DFS. The HS-mGPS appeared to have better prognostic effect than did the PLR and NLR, and the combination of the HS-mGPS and NLR appeared to exhibit optimal discriminative ability for OS prognostication. The nomogram based on the HS-mGPS and NLR yielded accurate OS prediction (concordance index = 0.803).

Conclusion

Our findings suggest that preoperative HS-mGPS is a promising prognostic biomarker of OSCC, and the nomogram comprising the HS-mGPS and NLR provided accurate individualized OSCC survival predictions.
Non-NMDA Mechanisms of Analgesia in Ketamine Analogs
Authors: Voss Logan J. , Harvey Martyn G. , Sleigh James W.
Published: February 2022

Despite 50 years of clinical use and experimental endeavor the anesthetic, analgesic, and psychomimetic effects of ketamine remain to be fully elucidated. While NMDA receptor antagonism has been long held as ketamine's fundamental molecular action, interrogation of bespoke ketamine analogs with known absent NMDA binding, yet profound anesthetic and analgesia fingerprints, suggests alternative targets are responsible for these effects. Herein we describe experimental findings utilizing such analogs as probes to explore ketamine-based analgesic molecular targets. We have focused on two-pore potassium leak channels, identifying TWIK channels as a rational target to pursue further. While the totality of ketamine's mechanistic action is yet to be fully determined, these investigations raise the intriguing prospect of separating out analgesia and anesthetic effects from ketamine's undesirable psychomimesis—and development of more specific analgesic medications.
Shallower Root Spatial Distribution Induced by Phosphorus Deficiency Contributes to Topsoil Foraging and Low Phosphorus Adaption in Sugarcane (Saccharum officinarum L.)
Authors: Yi Ke , Li Xiaofeng , Chen Diwen , Yang Shu , Liu Ying , Tang Xinlian , Ling Guizhi , Zhao Zunkang
Published: February 2022

Low phosphorus (P) availability in acid soils is one of the main limiting factors in sugarcane (Saccharum officinarum L.) production. Reconstruction of the root system architecture (RSA) is a vital mechanism for crop low P adaption, while the RSA of sugarcane has not been studied in detail because of its complex root system. In this study, reconstruction of the RSA and its relationship with P acquisition were investigated in a P-efficient sugarcane genotype ROC22 (R22) and two P-inefficient genotypes Yunzhe 03-103 (YZ) and Japan 2 (JP). An efficient dynamic observation room was developed to monitor the spatiotemporal alternation of sugarcane root length density (RLD) and root distribution in soil with heterogeneous P locations. The sugarcane RSA was reconstructed under P deficiency, and R22 had an earlier response than YZ and JP and presented an obvious feature of root shallowness. Compared with the normal P condition, the shallow RLD was increased by 112% in R22 under P deficiency while decreased by 26% in YZ and not modified in JP. Meanwhile, R22 exhibited a shallower root distribution than YZ and JP under P deficiency, supported by 51 and 24% greater shallow RLD, and 96 and 67% greater shallow root weight, respectively. The ratio of shallow RLD to total RLD in R22 was 91% greater than YZ, and the ratio of shallow root weight to total root weight in R22 was greater than that of YZ and JP by 94 and 30%, respectively. As a result, R22 had a higher shoot P accumulation than YZ and JP, which thereby increased the relative leaf sheath inorganic P concentration (RLPC) by 47 and 56%, relative shoot biomass (RSB) by 36 and 33%, and relative cane weight (RCW) by 31 and 36%, compared with YZ and JP under P deficiency, respectively. We verified the reliability and efficiency of a dynamic observation room and demonstrated that a shallower root distribution contributed to improving topsoil foraging, P acquisition, and low P adaption under P deficiency in sugarcane. Therefore, a shallower root distribution merits consideration as an evaluation trait for breeding P efficient sugarcane genotypes and genetic improvement.
Analyzing the Impact of Greenhouse Planting Strategy and Plant Architecture on Tomato Plant Physiology and Estimated Dry Matter
Authors: Zhang Yue , Henke Michael , Li Yiming , Xu Demin , Liu Anhua , Liu Xingan , Li Tianlai
Published: February 2022

Determine the level of significance of planting strategy and plant architecture and how they affect plant physiology and dry matter accumulation within greenhouses is essential to actual greenhouse plant management and breeding. We thus analyzed four planting strategies (plant spacing, furrow distance, row orientation, planting pattern) and eight different plant architectural traits (internode length, leaf azimuth angle, leaf elevation angle, leaf length, leaflet curve, leaflet elevation, leaflet number/area ratio, leaflet length/width ratio) with the same plant leaf area using a formerly developed functional–structural model for a Chinese Liaoshen-solar greenhouse and tomato plant, which used to simulate the plant physiology of light interception, temperature, stomatal conductance, photosynthesis, and dry matter. Our study led to the conclusion that the planting strategies have a more significant impact overall on plant radiation, temperature, photosynthesis, and dry matter compared to plant architecture changes. According to our findings, increasing the plant spacing will have the most significant impact to increase light interception. E–W orientation has better total light interception but yet weaker light uniformity. Changes in planting patterns have limited influence on the overall canopy physiology. Increasing the plant leaflet area by leaflet N/A ratio from what we could observe for a rose the total dry matter by 6.6%, which is significantly better than all the other plant architecture traits. An ideal tomato plant architecture which combined all the above optimal architectural traits was also designed to provide guidance on phenotypic traits selection of breeding process. The combined analysis approach described herein established the causal relationship between investigated traits, which could directly apply to provide management and breeding insights on other plant species with different solar greenhouse structures.
Patient Management Strategies in Perioperative, Intraoperative, and Postoperative Period in Breast Reconstruction With DIEP-Flap: Clinical Recommendations
Authors: Chen Kuo , Beeraka Narasimha M. , Sinelnikov Mikhail Y. , Zhang Jin , Song Dajiang , Gu Yuanting , Li Jingruo , Reshetov I. V. , Startseva O. I. , Liu Junqi , Fan Ruitai , Lu Pengwei
Published: February 2022

Background and Objective

Deep Inferior Epigastric Perforator (DIEP) flap is a tissue isolated from the skin and subcutaneous tissue of the lower abdomen or rectus muscle to foster breast reconstruction. There is limited information about DIEP-flap induced complications associated with breast reconstruction surgery.

Evidence

We conducted a systematic review of the published literature in the field of breast cancer reconstruction surgery. Information was gathered through internet resources such as PubMed, Medline, eMedicine, NLM, and ReleMed etc. The following key phrases were used for effective literature collection: “DIEP flap”, “Breast reconstruction”, “Patient management”, “Postoperative DIEP”, “Intraoperative anticoagulant therapy”, “Clinical recommendations”. A total of 106 research papers were retrieved pertaining to this systematic review.

Conclusion

A successful breast reconstruction with DIEP-flap without complications is the priority achievement for this surgical procedure. This study provides various evidence-based recommendations on patient management in the perioperative, intraoperative, and postoperative periods. The clinical recommendations provided in this review can benefit surgeons to execute breast reconstruction surgery with minimal postoperative complications. These recommendations are beneficial to improve clinical outcomes when performing surgery by minimizing complications in perioperative, intraoperative, and postoperative period.
Effects of Transient Electrical Acupuncture Stimulation Combined With Rehabilitation Training on Hemorheology, Neurological Function and BDNF in Patients With Cerebral Infarction
Authors: Chen Shuangqin , Huang Jianghua , Tang Xuan , Wang Ting , Zeng Yahua
Published: February 2022

Objective

To explore the effects of transient electric acupuncture stimulation combined with rehabilitation training on hemorheology, neurological function and brain-derived neurotrophic factor (BDNF) in patients with cerebral infarction (CI).

Methods

A total of 90 patients with CI were admitted to our hospital from March 2019 to March 2021. According to the random number table method, 90 patients were divided into a control group (was treated with transient electrical acupuncture stimulation intervention treatment) and a therapy group (was treated with rehabilitation training on the basis of the control group), with 45 cases in each group. NIHSS score to detect neurological deficit; FMA score to detect motor function recovery; the clinical efficacy of the two groups of patients were compared; blood rheology analyzer to detect whole blood high shear viscosity, whole blood low shear viscosity, platelet aggregation rate and fibrinogen indicators; ELISA detects the content of BDNF in serum.

Results

There was no significant difference in NIHSS score, FMA score, clinical efficacy, hemorheology index, and BDNF content between the two groups of patients before treatment (P > 0.05). After treatment, the NIHSS score, whole blood high shear visible, whole blood low shear visible, platelet aggregation rate and fibrinogen index of the two groups were lower than those before treatment, and the FMA score and BDNF content of the two groups were higher than those before treatment, and all the above indicators in the therapy group changed significantly compared with the control group (P < 0.05). After treatment, the clinical efficacy of the therapy group was better than that of the control group (P < 0.05).

Conclusion

The combination of transient electrical acupuncture stimulation and rehabilitation training can inhibit the blood flow index of patients with CI, improve the nerve function, increase the content of BDNF in the patient's serum, and restore the patient's nerve function.
Application of Operating Room Nursing Intervention to Incision Infection of Patients Undergoing Gastrointestinal Surgery Can Reduce Complications and Improve Gastrointestinal Function
Authors: Wang Ping , Chen Hong , Ji Qi
Published: February 2022

Objective

To observe the influence of nursing intervention in operation rooms on incision infection of patients undergoing gastrointestinal surgery and the improvement of gastrointestinal function.

Methods

A total of 340 patients who underwent gastrointestinal surgery in our hospital from June 2020 to August 2021 were included. According to the random number table, they were divided into the conventional nursing group (n = 170) and the operating room nursing group (n = 170). The conventional nursing group was treated with routine nursing intervention, while the operating room nursing group was treated with operating room nursing intervention. The incision infection, healing, gastrointestinal function recovery, and complications in the two groups were compared, and the patient care satisfaction was recorded.

Results

The incidence of incision swelling, pain, and incision secretion in the operating room nursing group was significantly lower than that in the conventional nursing group (p < 0.05). The patients in the operating room nursing group had higher grade A healing than in the conventional nursing group, and lower grade B and grade C healing than in the conventional nursing group (p < 0.05). The time of anal exhaust, first defecation, and the time of gastric tube removal in the operating room nursing group were lower than those in the conventional nursing group (p < 0.05). The incidence of postoperative complications, such as incision infection, incision dehiscence, early inflammatory bowel adhesion, and abdominal abscess, in the operating room nursing group was lower than that in the conventional nursing group (p < 0.05). The total satisfaction degree in the operating room nursing group was significantly higher than that in the conventional nursing group (p < 0.05).

Conclusion

Nursing intervention in operation room can reduce complications and improve gastrointestinal function when applied to patients undergoing gastrointestinal surgery due to incision infection.
Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention
Authors: Yang Qiu Ping , Chen Yuan Yuan , Li Zhenzhen , Xu Mingming
Published: February 2022

Objective

To observe the main risk factors for pruritic skin evidence complicating type 2 diabetes mellitus (T2DM) and the effectiveness of interventions with comprehensive care measures.

Methods

Two hundred and twenty four patients with T2DM admitted to our hospital from June 2020 to November 2021 were selected and divided into Diabetic pruritus group (DP group, n = 71) and T2DM group (n = 153) according to the patients' complications of pruritus. General information such as gender, age, body mass index (BMI), duration of illness, family history, treatment modalities, other comorbidities, underlying illnesses were collected from all patients. Fasting plasma glucose (FPG), renal function [Serum creatinine (Scr), urea nitrogen (BUN), uric acid (BUA)], lipid levels [total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)] were measured in all patients on day 2 after admission. Risk factors for pruritus complicating T2DM were identified by single multifactorial analysis. Meanwhile, patients in the DP group were divided into group A (n = 35) and group B (n = 36) using the random number table method. Group A adopted the conventional care mode and group B patients adopted the comprehensive care interventions to compare the care effects [visual analog score (VAS) before and after care, treatment efficiency, care satisfaction rate] of patients in groups A and B; the levels of pruritus mediator indicators [substance P,β-endorphin (β-EP) and γ-interferon (INF-γ)] before and after care.

Results

Risk factors for pruritus in T2DM were age, duration of DM, combined Diabetic peripheral neuropathy (DPN), combined diabetic retinopathy (DR), combined diabetic kidney disease (DKD) and serum FPG levels (P <0.05). Satisfaction rate of nursing care, treatment efficiency, post-care improvement in VAS scores, serum substance P, β-EP and INF-γ levels and other mediators of pruritus were better in Group B with integrated nursing intervention than in group A with conventional care only (P < 0.05).

Conclusion

Pruritus in T2DM is associated with age, duration of DM, combined DPN, combined DR, combined DKD and FPG levels. Comprehensive care according to the above risk factors can effectively relieve patients' clinical symptoms and signs, improve the level of pruritus mediators and patient-care relationship.
Are Foliar Fertilizers Beneficial to Growth and Yield of Wild Lowbush Blueberries?
Authors: Tasnim Rafa , Calderwood Lily , Tooley Brogan , Wang Lu , Zhang Yong-Jiang
Published: February 2022

Wild lowbush blueberry is an economically and culturally important crop in North America. Different fertilizer companies have been advertising their foliar fertilizer products to the wild blueberry growers, claiming better growth and production of this crop with no scientific proof. Although foliar fertilization has shown to be efficient for delivering micronutrients in deficit for different crops by reducing soil activation and environmental contamination, limited research has been done in wild blueberries. It is still unknown how foliar fertilizers affect the physiology, growth, and yield of this crop. Therefore, we tested the impacts of seven foliar treatments containing macro- and micro-nutrients and plant hormones (Seacrop16, Salvador, Agro-Phos applied in 2019 and Kali-T, Nano-Gro, Poma, Poma + Nanocellulose applied in 2020) on this crop for one crop cycle from vegetative year (2019) to crop year (2020). We tested these products against the standard soil-applied granular fertilizer called Diammonium phosphate (DAP) and control (no fertilizer) in a randomized complete block design with eight replicates in a conventional wild blueberry field in Maine, USA. In 2019, no significant differences across the applied treatments were observed in crop physiology and growth except in leaf chlorophyll concentration. In 2020, there was significantly higher leaf chlorophyll concentration in SeaCrop16 and Poma+Nanocellulose plots, but significantly lower photosynthetic rates in DAP and SeaCrop16 treated plots compared to the control. Meanwhile, no significant differences in plant height, leaf characteristics, or blueberry yield were found among the treatments. Overall, mobile nutrients (N, P, K) from soil applied fertilizers and foliar fertilizers containing other immobile nutrients (Ca) and/or plant hormones might benefit crop growth, but the impact on yield is limited. We also reveal that the wild blueberry physiological and morphological traits and leaf nutrients in the vegetative year are more related to the crop yield than those traits in the crop year. This implies that a combination of wild blueberry physiology, morphology, and leaf nutrients in the vegetative year largely impact their yield in the following crop year.
What Have We Learned after Millennia of Locust Invasions?
Authors: Lecoq Michel , Cease Arianne
Published: February 2022

Locust outbreaks have long been a very serious problem for agriculture and livelihoods in many countries globally. This article is an introduction to a Special Issue of the journal Agronomy devoted to the management of these pests. Although not exhaustive, the nineteen articles herein cover a variety of species, many regions of the world and many aspects of pest locust management and research in the early 21st century. This book is a source of information and reflection, as well as a resource, to support new areas of investigation and practice contributing to the process of developing sustainable solutions for locust invasions.
Chitosan-Induced Physiological and Biochemical Regulations Confer Drought Tolerance in Pot Marigold (Calendula officinalis L.)
Authors: Akhtar Gulzar , Faried Hafiz Nazar , Razzaq Kashif , Ullah Sami , Wattoo Fahad Masoud , Shehzad Muhammad Asif , Sajjad Yasar , Ahsan Muhammad , Javed Talha , Dessoky Eldessoky S. , Abdelsalam Nader R. , Chattha Muhammad Sohaib
Published: February 2022

Severe water stress conditions limit growth and development of floricultural crops which affects flower quality. Hence, development of effective approaches for drought tolerance is crucial to limit recurring water deficit challenges. Foliar application of various plant growth regulators has been evaluated to improve drought tolerance in different floricultural crops; however, reports regarding the role of chitosan (Ci) on seasonal flowers like calendula are still scant. Therefore, we evaluated the role of Ci foliar application on morphological, physiological, biochemical, and anatomical parameters of calendula under water stress conditions. Different doses of Ci (0, 2.5, 5, 7.5, 10 mg L−1) were applied through foliar application to evaluate their impact in enhancing growth and photosynthetic pigments of calendula. The optimized Ci level of 7.5 mg L−1 was further evaluated to study mechanisms of water stress tolerance in calendula. Ci application significantly increased biomass and pigments in calendula. Ci (7.5 mg L−1) resulted in increased photosynthetic rate (72.98%), transpiration rate (62.11%), stomatal conductance (59.54%), sub-stomatal conductance (20.62%), and water use efficiency (84.93%). Furthermore, it improved catalase, guaiacol peroxidase, and superoxide dismutase by 56.70%, 64.94%, and 32.41%, respectively. These results highlighted the significance of Ci in inducing drought tolerance in pot marigold.
TASE: Task-Aware Speech Enhancement for Wake-Up Word Detection in Voice Assistants
Authors: Cámbara Guillermo , López Fernando , Bonet David , Gómez Pablo , Segura Carlos , Farrús Mireia , Luque Jordi
Published: February 2022

Wake-up word spotting in noisy environments is a critical task for an excellent user experience with voice assistants. Unwanted activation of the device is often due to the presence of noises coming from background conversations, TVs, or other domestic appliances. In this work, we propose the use of a speech enhancement convolutional autoencoder, coupled with on-device keyword spotting, aimed at improving the trigger word detection in noisy environments. The end-to-end system learns by optimizing a linear combination of losses: a reconstruction-based loss, both at the log-mel spectrogram and at the waveform level, as well as a specific task loss that accounts for the cross-entropy error reported along the keyword spotting detection. We experiment with several neural network classifiers and report that deeply coupling the speech enhancement together with a wake-up word detector, e.g., by jointly training them, significantly improves the performance in the noisiest conditions. Additionally, we introduce a new publicly available speech database recorded for the Telefónica’s voice assistant, Aura. The OK Aura Wake-up Word Dataset incorporates rich metadata, such as speaker demographics or room conditions, and comprises hard negative examples that were studiously selected to present different levels of phonetic similarity with respect to the trigger words “OK Aura”.
Time-Resolved Imaging of Femtosecond Laser-Induced Plasma Expansion in a Nitrogen Microjet
Authors: Ciriolo Anna Gabriella , Martínez Vázquez Rebeca , Crippa Gabriele , Devetta Michele , Frezzotti Aldo , Comelli Daniela , Valentini Gianluca , Osellame Roberto , Vozzi Caterina , Stagira Salvatore
Published: February 2022

We report on the study of ultrafast laser-induced plasma expansion dynamics in a gas microjet. To this purpose, we focused femtosecond laser pulses on a nitrogen jet produced through a homemade De Laval micronozzle. The laser excitation led to plasma generation with a characteristic spectral line emission at 391 nm. By following the emitted signal with a detection system based on an intensified charge-coupled device (ICCD) we captured the two-dimensional spatial evolution of the photo-excited nitrogen ions with a temporal resolution on the nanosecond time scale. We fabricated the micronozzle on a fused silica substrate by femtosecond laser micromachining. This technique enabled high accuracy and three-dimensional capabilities, thus, providing an ideal platform for developing glass-based microfluidic structures for application to plasma physics and ultrafast spectroscopy.
Quantification of the Seismic Behavior of a Steel Transmission Tower Subjected to Single and Repeated Seismic Excitations Using Vulnerability Function and Collapse Margin Ratio
Authors: Kassem Moustafa Moufid , Beddu Salmia , Qi Min Wong , Tan Chee Ghuan , Mohamed Nazri Fadzli
Published: February 2022

Transmission towers are a vital lifeline for modern living and are crucial structures that must remain operational even after a seismic event. However, the towers are largely designed to withstand the effects of wind alone and not earthquakes, and the seismic influences on tower design and construction have hitherto been ignored. The purpose of this study was to evaluate the seismic performance of a latticed steel transmission tower-line system that is subjected to a variety of seismic situations (Far-Field, Near-Field and Repeated Earthquakes) using probabilistic vulnerability functions and Collapse Margin Ratios in accordance with FEMA-P695. Nonlinear Time History Analyses were performed by incorporating an array of 36 strong ground motions to develop the Incremental Dynamic Analysis and to generate the fragility functions for three performance limit states as referenced in FEMA 356. The results showed that the single event seismic performance of the tower is better than its performance after multiple ground motions owing to aftershock impact, while near-field excitations led to greater susceptibility and fragility than far-field scenarios. Thus, near-field ground motion is more harmful to the tower and could result in its failure or collapse with only a small reduction in damage relative to the impact of the aftershock.
Microbial Risk Assessment of Industrial Ice Cream Marketed in Italy
Authors: Nalbone Luca , Vallone Lisa , Giarratana Filippo , Virgone Gianluca , Lamberta Filippa , Marotta Stefania Maria , Donato Giorgio , Giuffrida Alessandro , Ziino Graziella
Published: February 2022

Ice cream is a frozen dairy dessert consumed worldwide. The frozen state may give a positive impression regarding microbiological safety; however, transmission of foodborne pathogens can also occur through ice cream consumption. A total of 200 samples of milk-based industrial ice cream, with and without inclusions, were purchased at different mass-market retailers in Italy and analyzed for the detection and enumeration of the aerobic colonies, Enterobacteriaceae, coagulase-positive staphylococci, Salmonella spp. and Listeria monocytogenes. Results were classified according to different ranges of acceptability, whose limits were set for each microbiological parameter. Unsatisfactory loads were obtained for two and nine samples as regarded the aerobic colonies and Enterobacteriaceae, respectively. L. monocytogenes was detected in 16 samples, and in three of them, the loads exceeded the legal limit of acceptability (≤100 cfu/g) during marketing. No unsatisfactory loads were obtained for coagulase-positive staphylococci and no Salmonella spp. was detected. The results obtained allow speculation that inclusions may be a relevant source of contamination for industrial ice cream. However, inadequate manufacturing and hygiene practices also threaten the safety of the finished product. Ice cream is a complex food matrix, and a comprehensive approach to the whole production system is required to ensure high standards of quality and safety.
Almost Anti-Periodic Discrete Oscillation of General N-Dimensional Mechanical System and Underactuated Euler-Lagrange System
Authors: Wang Chao , Wang Jie , Agarwal Ravi P. , Li Zhien
Published: February 2022

In this paper, we introduce the notions of the almost anti-periodic discrete process of the N-dimensional vector-valued and N×N matrix-valued functions. Some basic properties of the almost anti-periodic discrete functions are established. Based on this, the conditions of the stability and instability of the almost anti-periodic solutions to the general N-dimensional mechanical system and the underactuated Euler–Lagrange system have been considered. Moreover, some examples are provided to support our obtained results.