bluuebunny/crossref_metadata_2025 huggingface dataset:
Transferring Landscape Character Assessment from the UK to the Eastern Mediterranean: Challenges and Perspectives
Authors: Griffiths Geoffrey
Published: March 2018

Landscape character assessment (LCA) has a significant contribution to make as a spatial framework for the emerging concept of ‘multi-functional landscapes’, a landscape providing a range of functions, services, and human-derived benefits. The paper reviews the development of LCA in Northwest Europe with a brief description of more recent LCA projects in a Mediterranean context. This is followed by a comparative description of the Living Landscapes approach developed in the UK as applied to Cyprus. The focus is upon the challenges, and limitations, of transferring a method developed in one context to the different physical and cultural setting of the island of Cyprus examining differences in the definition of landscapes, the availability of information on the cultural landscape, the importance of incorporating a strong element of ‘time-depth’, and the potential of LCA for enhancing land use policy at a time of increased land pressures in the Mediterranean.
Au Nanoparticle Sub-Monolayers Sandwiched between Sol-Gel Oxide Thin Films
Authors: Della Gaspera Enrico , Menin Enrico , Maggioni Gianluigi , Sada Cinzia , Martucci Alessandro
Published: March 2018

Sub-monolayers of monodisperse Au colloids with different surface coverage have been embedded in between two different metal oxide thin films, combining sol-gel depositions and proper substrates functionalization processes. The synthetized films were TiO2, ZnO, and NiO. X-ray diffraction shows the crystallinity of all the oxides and verifies the nominal surface coverage of Au colloids. The surface plasmon resonance (SPR) of the metal nanoparticles is affected by both bottom and top oxides: in fact, the SPR peak of Au that is sandwiched between two different oxides is centered between the SPR frequencies of Au sub-monolayers covered with only one oxide, suggesting that Au colloids effectively lay in between the two oxide layers. The desired organization of Au nanoparticles and the morphological structure of the prepared multi-layered structures has been confirmed by Rutherford backscattering spectrometry (RBS), Secondary Ion Mass Spectrometry (SIMS), and Scanning Electron Microscopy (SEM) analyses that show a high quality sandwich structure. The multi-layered structures have been also tested as optical gas sensors.
Digital Image Correlation of 2D X-ray Powder Diffraction Data for Lattice Strain Evaluation
Authors: Zhang Hongjia , Sui Tan , Salvati Enrico , Daisenberger Dominik , Lunt Alexander , Fong Kai , Song Xu , Korsunsky Alexander
Published: March 2018

High energy 2D X-ray powder diffraction experiments are widely used for lattice strain measurement. The 2D to 1D conversion of diffraction patterns is a necessary step used to prepare the data for full pattern refinement, but is inefficient when only peak centre position information is required for lattice strain evaluation. The multi-step conversion process is likely to lead to increased errors associated with the ‘caking’ (radial binning) or fitting procedures. A new method is proposed here that relies on direct Digital Image Correlation analysis of 2D X-ray powder diffraction patterns (XRD-DIC, for short). As an example of using XRD-DIC, residual strain values along the central line in a Mg AZ31B alloy bar after 3-point bending are calculated by using both XRD-DIC and the conventional ‘caking’ with fitting procedures. Comparison of the results for strain values in different azimuthal angles demonstrates excellent agreement between the two methods. The principal strains and directions are calculated using multiple direction strain data, leading to full in-plane strain evaluation. It is therefore concluded that XRD-DIC provides a reliable and robust method for strain evaluation from 2D powder diffraction data. The XRD-DIC approach simplifies the analysis process by skipping 2D to 1D conversion, and opens new possibilities for robust 2D powder diffraction data analysis for full in-plane strain evaluation.
Gender Differences in Laser Acupuncture—Results of a Crossover Study with Green and Yellow Laser at the Ear Point Shenmen
Authors: Litscher Daniela , Wang Junying , Litscher Gerhard , Li Guangzong , Bosch Peggy , Van den Noort Maurits , Wang Lu
Published: March 2018

Background: One of the most commonly used auricular acupuncture points selected for different pain treatment regimens is Shenmen. This point on the ear has been recognized as having a wide number of applications, as found by scientific investigation. Methods: Within this crossover study, the ear acupoint Shenmen was stimulated with two different kinds of laser (green, 532 nm and yellow, 589 nm) in 22 healthy volunteers (13 female, 9 male; mean age ± SD = 25.3 ± 4.1 years; range 21–36 years). Both green and yellow lasers were used for 15 min in the same volunteers in two different sessions. Results: The most prominent finding was that systolic blood pressure decreased significantly (p = 0.048) after yellow laser stimulation. Heart rate also decreased significantly (p < 0.001), whereas heart rate variability ratio low frequency (LF)/high frequency (HF) (p < 0.001) increased. The effects were significantly more pronounced in females than in males. In addition, the temperature was measured, and temperature increases were demonstrated at different locations on the ear using imaging methods. Conclusions: This study shows evidence of the effect of auricular laser acupuncture. However, a comparison with other publications was impossible because this is the first study using green and yellow laser stimulation on the ear.
Flow Behavior Characteristics and Processing Map of Fe-6.5wt. %Si Alloys during Hot Compression
Authors: Wen Shibo , Han Chaoyu , Zhang Bao , Liang Yongfeng , Ye Feng , Lin Junpin
Published: March 2018

The flow behavior of Fe-6.5wt. %Si alloys during hot compression was investigated at temperatures 650–950 °C and strain rates 0.01–10 s−1. The results showed that the flow stress depended distinctly on the deformation temperatures and strain rates. The flow stress and work hardening rate increased with the decrease of temperature and the increase of strain rate. The activation energy under all the deformation conditions was calculated to be 410 kJ/mol. The constitutive equation with hyperbolic sine function and Zener–Hollomon parameter was developed. The peak stress, critical stress, and steady-state stress could be represented as σ = A + Bln(Z/A). Dynamic recrystallization occurred under the deformation conditions where the values of Z were lower than 1020. Processing maps were established to optimize the processing parameters. The power dissipation efficiency decreased in the high temperature and low strain rate region, increased in the high temperature and high strain rate region, and remained unchanged in other regions with the increase of true strain. Furthermore, the unstable area expanded. The true strain of 0.7 was the optimum reduction according to the processing map. Based on the analysis of surface quality, microstructures, and ordered structures, the optimized processing parameters for the Fe-6.5wt. %Si alloys were the temperature and strain rate of higher than 900 °C and 0.01–10 s−1, respectively, or 800–900 °C and lower than 0.4 s−1, respectively.
Digital Manufacturing of Selective Porous Barriers in Microchannels Using Multi-Material Stereolithography
Authors: Kim Yong , Castro Kurt , Bhattacharjee Nirveek , Folch Albert
Published: March 2018

We have developed a sequential stereolithographic co-printing process using two different resins for fabricating porous barriers in microfluidic devices. We 3D-printed microfluidic channels with a resin made of poly(ethylene glycol) diacrylate (MW = 258) (PEG-DA-258), a UV photoinitiator, and a UV sensitizer. The porous barriers were created within the microchannels in a different resin made of either PEG-DA (MW = 575) (PEG-DA-575) or 40% (w/w in water) PEG-DA (MW = 700) (40% PEG-DA-700). We showed selective hydrogen ion diffusion across a 3D-printed PEG-DA-575 porous barrier in a cross-channel diffusion chip by observing color changes in phenol red, a pH indicator. We also demonstrated the diffusion of fluorescein across a 3D-printed 40% PEG-DA-700 porous barrier in a symmetric-channel diffusion chip by measuring fluorescence intensity changes across the porous barrier. Creating microfluidic chips with integrated porous barriers using a semi-automated 3D printing process shortens the design and processing time, avoids assembly and bonding complications, and reduces manufacturing costs compared to micromolding processes. We believe that our digital manufacturing method for fabricating selective porous barriers provides an inexpensive, simple, convenient and reproducible route to molecule delivery in the fields of molecular filtration and cell-based microdevices.
A Label Free Disposable Device for Rapid Isolation of Rare Tumor Cells from Blood by Ultrasounds
Authors: González Itziar , Earl Julie , Fernández Luis , Sainz Bruno , Pinto Alberto , Monge Rosa , Alcalá Sonia , Castillejo Adela , Soto Jose , Carrato Alfredo
Published: March 2018

The use of blood samples as liquid biopsy is a label-free method for cancer diagnosis that offers benefits over traditional invasive biopsy techniques. Cell sorting by acoustic waves offers a means to separate rare cells from blood samples based on their physical properties in a label-free, contactless and biocompatible manner. Herein, we describe a flow-through separation approach that provides an efficient separation of tumor cells (TCs) from white blood cells (WBCs) in a microfluidic device, “THINUS-Chip” (Thin-Ultrasonic-Separator-Chip), actuated by ultrasounds. We introduce for the first time the concept of plate acoustic waves (PAW) applied to acoustophoresis as a new strategy. It lies in the geometrical chip design: different to other microseparators based on either bulk acoustic waves (BAW) or surface waves (SAW, SSAW and tSAW), it allows the use of polymeric materials without restrictions in the frequency of work. We demonstrate its ability to perform high-throughput isolation of TCs from WBCs, allowing a recovery rate of 84% ± 8% of TCs with a purity higher than 80% and combined viability of 85% at a flow rate of 80 μL/min (4.8 mL/h). The THINUS-Chip performs cell fractionation with low-cost manufacturing processes, opening the door to possible easy printing fabrication.
Crack-Configuration Analysis of Metal Conductive Track Embedded in Stretchable Elastomer
Authors: Koshi Tomoya , Iwase Eiji
Published: March 2018

This paper reports the analysis of the crack configuration of a stretched metal conductive track that is embedded in a stretchable elastomer. The factor determining the crack configurations is analyzed by modeling as well as experiments. The modeling analysis indicates that the crack configuration is determined by the ratio of the elongation stiffness of the track and elastomer, and is classified into two types: multiple-crack growth and single-crack growth. When the track stiffness is considerably lower than the elastomer stiffness, multiple-crack growth type occurs; in the opposite case, single-crack growth type occurs. Hence, to verify the modeling analysis, metal conductive tracks with different thicknesses are fabricated, and the cracks are studied with respect to the crack width, number of cracks, and crack propagation speed. In this study, two conventional metal-track shapes are studied: straight-shaped tracks with track thickness of 0.04–1.17 µm, and wave-shaped tracks with track thickness of 2–10 µm. For straight-shaped tracks, multiple-crack growth type occurred, when the track thickness was 0.04 µm, and the crack configuration gradually changed to a single crack, with the increase in the track thickness. For wave-shaped tracks with track thickness of 2–10 µm, only single-crack growth type occurred; however, the crack propagation speed decreased and the maximum stretchability of the track increased, with the increase in the track thickness.
Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus
Authors: Revoltella Silvia , Baraldo Giorgia , Waltenberger Birgit , Schwaiger Stefan , Kofler Philipp , Moesslacher Julia , Huber-Seidel Astrid , Pagitz Konrad , Kohl Roland , Jansen-Duerr Pidder , Stuppner Hermann
Published: March 2018

NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable source for the identification of novel bioactive natural products with anti-ageing effects, especially substances that protect plants against UV radiation, which is also known to contribute to the ageing of human skin. Therefore, the aim of this study was to identify novel Nox4 inhibitors from alpine plants. Within an initial screening of extracts of alpine plants on their ability to inhibit Nox4 activity in HEK cells, the methanolic extract of the subaerial parts of Lycopus europaeus showed a strong inhibition of Nox4 (81% chemiluminescence quenching) and a simultaneously high cell viability (91% vitality). Rosmarinic acid was isolated and identified as the major compound in this bioactive extract. It showed a dose dependent inhibitory activity on Nox4 with an IC50 of 1 µM. Moreover, it also showed a significant inhibitory activity on Nox2 in the low micromolar range, whereas no inhibition of Nox5 was detected. Further investigations confirmed that the observed effects of rosmarinic acid on Nox2 and Nox4 are real inhibitory activities, and not due to ROS scavenging effects. Therefore, L. europaeus, which we demonstrated to be a good source of rosmarinic acid, has great potential for usage in cosmeceutical products with anti-ageing activity.
Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum
Authors: Hong Ju-Mi , Suh Sung-Suk , Kim Tai , Kim Jung , Han Se , Youn Ui , Yim Joung , Kim Il-Chan
Published: March 2018

Lobaric acid and lobarstin, secondary metabolites derived from the antarctic lichen Stereocaulon alpnum, exert various biological activities, including antitumor, anti-proliferation, anti-inflammation, and antioxidant activities. However, the underlying mechanisms of these effects have not yet been elucidated in human cervix adenocarcinoma and human colon carcinoma. In the present study, we evaluated the anticancer effects of lobaric acid and lobarstin on human cervix adenocarcinoma HeLa cells and colon carcinoma HCT116 cells. We show that the proliferation of Hela and HCT116 cells treated with lobaric acid and lobarstin significantly decreased in a dose- and time-dependent manner. Using flow cytometry analysis, we observed that the treatment with these compounds resulted in significant apoptosis in both cell lines, following cell cycle perturbation and arrest in G2/M phase. Furthermore, using immunoblot analysis, we investigated the expression of cell cycle and apoptosis-related marker genes and found a significant downregulation of the apoptosis regulator B-cell lymphoma 2 (Bcl-2) and upregulation of the cleaved form of the poly (ADP-ribose) polymerase (PARP), a DNA repair and apoptosis regulator. These results suggest that lobaric acid and lobarstin could significantly inhibit cell proliferation through cell cycle arrest and induction of apoptosis via the mitochondrial apoptotic pathway in cervix adenocarcinoma and colon carcinoma cells. Taken together, our data suggests that lobaric acid and lobarstin might be novel agents for clinical treatment of cervix adenocarcinoma and colon carcinoma.
One-Step Fabrication of Dual Responsive Lignin Coated Fe3O4 Nanoparticles for Efficient Removal of Cationic and Anionic Dyes
Authors: Li Xingang , He Youyi , Sui Hong , He Lin
Published: March 2018

A new, simple one-step approach has been developed to synthesize lignin and lignin amine coated Fe3O4 nanoparticles. These nanoparticles (lignin magnetic nanoparticles (LMNPs) and lignin amine magnetic nanoparticles (LAMNPs)) are found to possess not only magnetic response but also pH-dependent adsorption behavior. Results show that the combination of lignin with nanoparticles increased the adsorption capacities 2–5 times higher than other traditional single lignin based adsorbents (211.42 mg/g for methylene blue (MB) by LMNPs and 176.49 mg/g for acid scarlet GR (AS-GR) by LAMNPs). Meanwhile, by simply adjusting the pH, the dye-loaded adsorbents can be regenerated to recycle both adsorbents and dyes with a desorption efficiency up to 90%. Mechanistic study shows that dye structure and surface charges of adsorbents play the most important part in adsorption where dyes interact with the adsorbent surface via π–π stacking and electrostatic attraction interactions. The efficient fabrication method, eco-friendly reactant, quick magnetic separation, high adsorption and desorption efficiency suggest this novel type of nano-adsorbents to be promising materials for efficient dye pollutant removal and recovery.
Enhancing the Microparticle Deposition Stability and Homogeneity on Planer for Synthesis of Self-Assembly Monolayer
Authors: Shih An-Ci , Han Chi-Jui , Kuo Tsung-Cheng , Cheng Yun-Chien
Published: March 2018

The deposition stability and homogeneity of microparticles improved with mask, lengthened nozzle and flow rate adjustment. The microparticles can be used to encapsulate monomers, before the monomers in the microparticles can be deposited onto a substrate for nanoscale self-assembly. For the uniformity of the synthesized nanofilm, the homogeneity of the deposited microparticles becomes an important issue. Based on the ANSYS simulation results, the effects of secondary flow were minimized with a lengthened nozzle. The ANSYS simulation was also used to investigate the ring-vortex generation and why the ring vortex can be eliminated by adding a mask with an aperture between the nozzle and deposition substrate. The experimental results also showed that particle deposition with a lengthened nozzle was more stable, while adding the mask stabilized deposition and diminished the ring-vortex contamination. The effects of flow rate and pressure were also investigated. Hence, the deposition stability and homogeneity of microparticles was improved.
The Hydrolytic Stability and Degradation Mechanism of a Hierarchically Porous Metal Alkylphosphonate Framework
Authors: Lv Kai , Yang Chu-Ting , Liu Yi , Hu Sheng , Wang Xiao-Lin
Published: March 2018

To aid the design of a hierarchically porous unconventional metal-phosphonate framework (HP-UMPF) for practical radioanalytical separation, a systematic investigation of the hydrolytic stability of bulk phase against acidic corrosion has been carried out for an archetypical HP-UMPF. Bulk dissolution results suggest that aqueous acidity has a more paramount effect on incongruent leaching than the temperature, and the kinetic stability reaches equilibrium by way of an accumulation of a partial leached species on the corrosion conduits. A variation of particle morphology, hierarchical porosity and backbone composition upon corrosion reveals that they are hydrolytically resilient without suffering any great degradation of porous texture, although large aggregates crack into sporadic fractures while the nucleophilic attack of inorganic layers cause the leaching of tin and phosphorus. The remaining selectivity of these HP-UMPFs is dictated by a balance between the elimination of free phosphonate and the exposure of confined phosphonates, thus allowing a real-time tailor of radionuclide sequestration. Moreover, a plausible degradation mechanism has been proposed for the triple progressive dissolution of three-level hierarchical porous structures to elucidate resultant reactivity. These HP-UMPFs are compared with benchmark metal-organic frameworks (MOFs) to obtain a rough grading of hydrolytic stability and two feasible approaches are suggested for enhancing their hydrolytic stability that are intended for real-life separation protocols.
Self-Reported Fractures in Dermatitis Herpetiformis Compared to Coeliac Disease
Authors: Pasternack Camilla , Mansikka Eriika , Kaukinen Katri , Hervonen Kaisa , Reunala Timo , Collin Pekka , Huhtala Heini , Mattila Ville , Salmi Teea
Published: March 2018

Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. Increased bone fracture risk is known to associate with coeliac disease, but this has been only scantly studied in DH. In this study, self-reported fractures and fracture-associated factors in DH were investigated and compared to coeliac disease. Altogether, 222 DH patients and 129 coeliac disease-suffering controls were enrolled in this study. The Disease Related Questionnaire and the Gastrointestinal Symptom Rating Scale and Psychological General Well-Being questionnaires were mailed to participants; 45 out of 222 (20%) DH patients and 35 out of 129 (27%) of the coeliac disease controls had experienced at least one fracture (p = 0.140). The cumulative lifetime fracture incidence did not differ between DH and coeliac disease patients, but the cumulative incidence of fractures after diagnosis was statistically significantly higher in females with coeliac disease compared to females with DH. The DH patients and the coeliac disease controls with fractures reported more severe reflux symptoms compared to those without, and they also more frequently used proton-pump inhibitor medication. To conclude, the self-reported lifetime bone fracture risk is equal for DH and coeliac disease. After diagnosis, females with coeliac disease have a higher fracture risk than females with DH.
Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis
Authors: Zhang Enxiang , Yin Shutao , Lu Xiaotong , Ye Linhu , Fan Lihong , Hu Hongbo
Published: March 2018

Glycycoumarin (GCM) is a representative of bioactive coumarin compounds isolated from licorice, an edible and medicinal plant widely used for treating various diseases including liver diseases. The purpose of the present study is to examine the possibility of GCM as a sensitizer to improve the efficacy of BH3 mimetic ABT-737 against liver cancer. Three liver cancer cell lines (HepG2, Huh-7 and SMMC-7721) were used to evaluate the in vitro combinatory effect of ABT-737/GCM. HepG2 xenograft model was employed to assess the in vivo efficacy of ABT-737/GCM combination. Results showed that GCM was able to significantly sensitize liver cancer cells to ABT-737 in both in vitro and in vivo models. The enhanced efficacy by the combination of ABT-737 and GCM was attributed to the inactivation of T-LAK cell-originated protein kinase (TOPK)-survivin axis and inhibition of de novo lipogenesis. Our findings have identified induction of TOPK-survivin axis as a novel mechanism rendering cancer cells resistant to ABT-737. In addition, ABT-737-induced platelet toxicity was attenuated by the combination. The findings of the present study implicate that bioactive coumarin compound GCM holds great potential to be used as a novel chemo-enhancer to improve the efficacy of BH3 mimetic-based therapy.
Scalar Fields as Sources for Wormholes and Regular Black Holes
Authors: Bronnikov Kirill
Published: March 2018

We review nonsingular static, spherically symmetric solutions of general relativity with minimally coupled scalar fields. Considered are wormholes and regular black holes (BHs) without a center, including black universes (BHs with expanding cosmology beyond the horizon). Such configurations require a “ghost” field with negative kinetic energy K. Ghosts can be invisible under usual conditions if K < 0 only in strong-field region (“trapped ghost”), or they rapidly decay at large radii. Before discussing particular examples, some general results are presented, such as the necessity of anisotropic matter for asymptotically flat or AdS wormholes, no-hair and global structure theorems for BHs with scalar fields. The stability properties of scalar wormholes and regular BHs under spherical perturbations are discussed. It is stressed that the effective potential V eff for perturbations has universal shapes near generic wormhole throats (a positive pole regularizable by a Darboux transformation) and near transition surfaces from canonical to ghost scalar field behavior (a negative pole at which the perturbation finiteness requirement plays a stabilizing role). Positive poles of V eff emerging at “long throats” (with the radius r ≈ r 0 + const · x 2 n , n > 1 , x = 0 is the throat) may be regularized by repeated Darboux transformations for some values of n.
Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
Authors: Sonvico Fabio , Clementino Adryana , Buttini Francesca , Colombo Gaia , Pescina Silvia , Stanisçuaski Guterres Silvia , Raffin Pohlmann Adriana , Nicoli Sara
Published: March 2018

In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects. Recently, nasal administration of insulin showed promising results in clinical trials for the treatment of Alzheimer’s disease. Nanomedicines could further contribute to making nose-to-brain delivery a reality. While not disregarding the need for devices enabling a formulation deposition in the nose’s upper part, surface modification of nanomedicines appears the key strategy to optimize drug delivery from the nasal cavity to the brain. In this review, nanomedicine delivery based on particle engineering exploiting surface electrostatic charges, mucoadhesive polymers, or chemical moieties targeting the nasal epithelium will be discussed and critically evaluated in relation to nose-to-brain delivery.
Isolation and Rheological Characterization of Cellulose Nanofibrils (CNFs) from Coir Fibers in Comparison to Wood and Cotton
Authors: Yue Daran , Qian Xueren
Published: March 2018

In this report, the isolation and rheological characterization of cellulose nanofibrils from coir (CNFs-1) were studied and compared with the CNFs from wood (CNFs-2) and cotton (CNFs-3). Cellulose nanofibrils were isolated successfully from coir fibers by chemical treatments followed by ultrasonic fibrillation. During ultrasonic processing, the size and the crystal structure of the CNFs were influenced by the raw materials. In comparison to CNFs-2 and CNFs-3, CNFs-1 from coir fibers presented diverse advantages, such as sufficient fibrillation with a low diameter distribution, in the range of 2–4 nm and high crystallinity. In the dynamic rheology study of CNFs-1, elastic behavior was observed and maintained due to the formation of gel-like steady network structures, which could not be easily deconstructured by frequency shearing and temperature changing. All results indicated that coir fibers could be used as a valuable resource for the preparation of CNFs, which exhibited comparable properties with those isolated from wood, in regard to morphology and rheological properties. This work provides a basis for further advanced applications using the CNFs isolated from coir fibers.
Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery
Authors: Ji Feng , Sun Hong , Qin Zhihui , Zhang Ershuai , Cui Jing , Wang Jinmei , Li Shuofeng , Yao Fanglian
Published: March 2018

Multifunctional drug carriers have great applications in biomedical field. In this study, we introduced both polydopamine (PDA) and zwitterionic polymer of poly(3-(3-methacrylamidopropyl-(dimethyl)-ammonio)propane-1-sulfonate) (PSPP) onto the surface of mesoporous silica nanoparticles (MSNs) to develop a novel nanoparticle (MSNs@PDA-PSPP), which was employed as a new kind of drug carrier for the delivery of doxorubicin (DOX). The PDA coating, as a gatekeeper, could endow the drug carrier with pH-sensitive drug release performance. The outermost PSPP layer would make the drug carrier possess protein resistance performance. The chemical structure and properties were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermogravimetric analysis (TGA). MSNs@PDA-PSPP could keep good colloidal stability within 72 h in phosphate buffered saline (PBS) and protein solutions. Meanwhile, MSNs@PDA-PSPP exhibited a high drug loading for DOX. In vitro drug release experiments suggested MSNs-DOX@PDA-PSPP exhibited pH-dependent drug release behaviors. Besides, MSNs@PDA-PSPP had no cytotoxicity to human hepatocellular carcinoma cells (HepG2 cells) even at a concentration of 125 µg/mL. More importantly, cellular uptake and in vitro anticancer activity tests suggested that MSNs-DOX@PDA-PSPP could be taken up by HepG2 cells and DOX could be successfully released and delivered into the cell nuclei. Taken together, MSNs@PDA-PSPP have great potential in the biomedical field.
Library Assessment Research: A Content Comparison from Three American Library Journals
Authors: Allen Ethan , Weber Roberta , Howerton William
Published: March 2018

Improvement of academic library services as an outcome of continuous assessment is an aim of libraries of higher education institutions. Academic libraries are realizing the need to document evidence of their value to the institutions and the patrons they serve. Publications that include assessment research are reaching library decision makers, who seek to apply evidence to improve services or implement best practices that benefit all stakeholders. Following two previous studies that reported longitudinally on front-line library services, this paper investigates current five-year trending of three prestigious academic library journals in the publication of assessment studies. Data for this study were drawn through a content analysis process, in which the investigators selected studies for inclusion using a set of criteria developed in a pilot exercise. After individually examining 649 research articles, published between 2012 and 2016, 126 met the study’s selection criteria and were categorized according to the type of service they studied. Papers on information literacy instruction dominated, while reference services, technology, and general assessment studies saw less representation in the three journals. This finding reflects the priority placed upon information literacy instruction and describes how three American library journals are responding to current trends across academic libraries.
Proof of Feasibility of the Sea State Monitoring from Data Collected in Medium Pulse Mode by a X-Band Wave Radar System
Authors: Ludeno Giovanni , Raffa Francesco , Soldovieri Francesco , Serafino Francesco
Published: March 2018

X-band marine radars can be exploited to estimate the sea state parameters and surface current. However, to pursue this aim, they are set in such a way as to radiate a very short pulse to exploit the maximum spatial resolution. However, this condition strongly limits the use of radar as an anti-collision system during navigation. Consequently, a continuous change of radar scale is needed to perform both the operations of waves and current estimations and target tracking activities. The goal of this manuscript is to investigate the possibility of using marine radar working in a medium pulse mode to estimate the sea state parameters and surface current, while assuring suitable anti-collision performance. Specifically, we compare the capabilities of the X-band radar for sea state monitoring when it works in short and medium pulse modes and we present the results of a comparison based on data collected during two experimental campaigns. The provided results show that there is good agreement about the estimation of wave parameters and the surface current field that make us hopeful that, in principle, it is possible to use the medium pulse mode to achieve information about sea state with a reasonable degradation.
Using Landsat Spectral Indices in Time-Series to Assess Wildfire Disturbance and Recovery
Authors: Hislop Samuel , Jones Simon , Soto-Berelov Mariela , Skidmore Andrew , Haywood Andrew , Nguyen Trung
Published: March 2018

Satellite earth observation is being increasingly used to monitor forests across the world. Freely available Landsat data stretching back four decades, coupled with advances in computer processing capabilities, has enabled new time-series techniques for analyzing forest change. Typically, these methods track individual pixel values over time, through the use of various spectral indices. This study examines the utility of eight spectral indices for characterizing fire disturbance and recovery in sclerophyll forests, in order to determine their relative merits in the context of Landsat time-series. Although existing research into Landsat indices is comprehensive, this study presents a new approach, by comparing the distributions of pre and post-fire pixels using Glass’s delta, for evaluating indices without the need of detailed field information. Our results show that in the sclerophyll forests of southeast Australia, common indices, such as the Normalized Difference Vegetation Index (NDVI) and the Normalized Burn Ratio (NBR), both accurately capture wildfire disturbance in a pixel-based time-series approach, especially if images from soon after the disturbance are available. However, for tracking forest regrowth and recovery, indices, such as NDVI, which typically capture chlorophyll concentration or canopy ‘greenness’, are not as reliable, with values returning to pre-fire levels in 3–5 years. In comparison, indices that are more sensitive to forest moisture and structure, such as NBR, indicate much longer (8–10 years) recovery timeframes. This finding is consistent with studies that were conducted in other forest types. We also demonstrate that additional information regarding forest condition, particularly in relation to recovery, can be extracted from less well known indices, such as NBR2, as well as textural indices incorporating spatial variance. With Landsat time-series gaining in popularity in recent years, it is critical to understand the advantages and limitations of the various indices that these methods rely on.
A New MODIS C6 Dark Target and Deep Blue Merged Aerosol Product on a 3 km Spatial Grid
Authors: Bilal Muhammad , Qiu Zhongfeng , Campbell James , Spak Scott , Shen Xiaojing , Nazeer Majid
Published: March 2018

In Moderate Resolution Imaging Spectroradiometer (MODIS) Collection (C6) aerosol products, the Dark Target (DT) and Deep Blue (DB) algorithms provide aerosol optical depth (AOD) observations at 3 km (DT3K) and 10 km (DT10K), and at 10 km resolution (DB10K), respectively. In this study, the DB10K is resampled to 3 km grid (DB3K) using the nearest neighbor interpolation technique and merged with DT3K to generate a new DT and DB merged aerosol product (DTB3K) on a 3 km grid using Simplified Merge Scheme (SMS). The goal is to supplement DB10K with high-resolution information over dense vegetation regions where DT3K is susceptible to error. SMS is defined as “an average of the DT3K and DB3K AOD retrievals or the available one with the highest quality flag”. The DT3K and DTB3K AOD retrievals are validated from 2008 to 2012 against cloud-screened and quality-assured AOD from 19 AERONET sites located in Europe. Results show that the percentage of DTB3K retrievals within the expected error (EE = ± (0.05 + 20%)) and data counts are increased by 40% and 11%, respectively, and the root mean square error and the mean bias are decreased by 26% and 54%, respectively, compared to the DT3K retrievals. These results suggest that the DTB3K product is a robust improvement over DT3K alone, and can be used operationally for air quality and climate-related studies as a high-resolution supplement to the current MODIS product suite.
A Review of Multimode Interference in Tapered Optical Fibers and Related Applications
Authors: Wang Pengfei , Zhao Haiyan , Wang Xianfan , Farrell Gerald , Brambilla Gilberto
Published: March 2018

In recent years, tapered optical fibers (TOFs) have attracted increasing interest and developed into a range of devices used in many practical applications ranging from optical communication, sensing to optical manipulation and high-Q resonators. Compared with conventional optical fibers, TOFs possess a range of unique features, such as large evanescent field, strong optical confinement, mechanical flexibility and compactness. In this review, we critically summarize the multimode interference in TOFs and some of its applications with a focus on our research project undertaken at the Optoelectronics Research Centre of the University of Southampton in the United Kingdom.
First Evaluation of Infrared Thermography as a Tool for the Monitoring of Udder Health Status in Farms of Dairy Cows
Authors: Zaninelli Mauro , Redaelli Veronica , Luzi Fabio , Bronzo Valerio , Mitchell Malcolm , Dell’Orto Vittorio , Bontempo Valentino , Cattaneo Donata , Savoini Giovanni
Published: March 2018

The aim of the present study was to test infrared thermography (IRT), under field conditions, as a possible tool for the evaluation of cow udder health status. Thermographic images (n. 310) from different farms (n. 3) were collected and evaluated using a dedicated software application to calculate automatically and in a standardized way, thermographic indices of each udder. Results obtained have confirmed a significant relationship between udder surface skin temperature (USST) and classes of somatic cell count in collected milk samples. Sensitivity and specificity in the classification of udder health were: 78.6% and 77.9%, respectively, considering a level of somatic cell count (SCC) of 200,000 cells/mL as a threshold to classify a subclinical mastitis or 71.4% and 71.6%, respectively when a threshold of 400,000 cells/mL was adopted. Even though the sensitivity and specificity were lower than in other published papers dealing with non-automated analysis of IRT images, they were considered acceptable as a first field application of this new and developing technology. Future research will permit further improvements in the use of IRT, at farm level. Such improvements could be attained through further image processing and enhancement, and the application of indicators developed and tested in the present study with the purpose of developing a monitoring system for the automatic and early detection of mastitis in individual animals on commercial farms.
New Spectral Index for Detecting Wheat Yellow Rust Using Sentinel-2 Multispectral Imagery
Authors: Zheng Qiong , Huang Wenjiang , Cui Ximin , Shi Yue , Liu Linyi
Published: March 2018

Yellow rust is one of the most destructive diseases for winter wheat and has led to a significant decrease in winter wheat quality and yield. Identifying and monitoring yellow rust is of great importance for guiding agricultural production over large areas. Compared with traditional crop disease discrimination methods, remote sensing technology has proven to be a useful tool for accomplishing such a task at large scale. This study explores the potential of the Sentinel-2 Multispectral Instrument (MSI), a newly launched satellite with refined spatial resolution and three red-edge bands, for discriminating between yellow rust infection severities (i.e., healthy, slight, and severe) in winter wheat. The corresponding simulative multispectral bands for the Sentinel-2 sensor were calculated by the sensor’s relative spectral response (RSR) function based on the in situ hyperspectral data acquired at the canopy level. Three Sentinel-2 spectral bands, including B4 (Red), B5 (Re1), and B7 (Re3), were found to be sensitive bands using the random forest (RF) method. A new multispectral index, the Red Edge Disease Stress Index (REDSI), which consists of these sensitive bands, was proposed to detect yellow rust infection at different severity levels. The overall identification accuracy for REDSI was 84.1% and the kappa coefficient was 0.76. Moreover, REDSI performed better than other commonly used disease spectral indexes for yellow rust discrimination at the canopy scale. The optimal threshold method was adopted for mapping yellow rust infection at regional scales based on realistic Sentinel-2 multispectral image data to further assess REDSI’s ability for yellow rust detection. The overall accuracy was 85.2% and kappa coefficient was 0.67, which was found through validation against a set of field survey data. This study suggests that the Sentinel-2 MSI has the potential for yellow rust discrimination, and the newly proposed REDSI has great robustness and generalized ability for yellow rust detection at canopy and regional scales. Furthermore, our results suggest that the above remote sensing technology can be used to provide scientific guidance for monitoring and precise management of crop diseases and pests.
Mechanical, Electrical and Magnetic Properties of Ferrogels with Embedded Iron Oxide Nanoparticles Obtained by Laser Target Evaporation: Focus on Multifunctional Biosensor Applications
Authors: Blyakhman Felix , Buznikov Nikita , Sklyar Tatyana , Safronov Alexander , Golubeva Elizaveta , Svalov Andrey , Sokolov Sergey , Melnikov Grigory , Orue Iñaki , Kurlyandskaya Galina
Published: March 2018

Hydrogels are biomimetic materials widely used in the area of biomedical engineering and biosensing. Ferrogels (FG) are magnetic composites capable of functioning as magnetic field sensitive transformers and field assisted drug deliverers. FG can be prepared by incorporating magnetic nanoparticles (MNPs) into chemically crosslinked hydrogels. The properties of biomimetic ferrogels for multifunctional biosensor applications can be set up by synthesis. The properties of these biomimetic ferrogels can be thoroughly controlled in a physical experiment environment which is much less demanding than biotests. Two series of ferrogels (soft and dense) based on polyacrylamide (PAAm) with different chemical network densities were synthesized by free-radical polymerization in aqueous solution with N,N’-methylene-diacrylamide as a cross-linker and maghemite Fe2O3 MNPs fabricated by laser target evaporation as a filler. Their mechanical, electrical and magnetic properties were comparatively analyzed. We developed a giant magnetoimpedance (MI) sensor prototype with multilayered FeNi-based sensitive elements deposited onto glass or polymer substrates adapted for FG studies. The MI measurements in the initial state and in the presence of FG with different concentrations of MNPs at a frequency range of 1–300 MHz allowed a precise characterization of the stray fields of the MNPs present in the FG. We proposed an electrodynamic model to describe the MI in multilayered film with a FG layer based on the solution of linearized Maxwell equations for the electromagnetic fields coupled with the Landau-Lifshitz equation for the magnetization dynamics.
Trends Supporting the In-Field Use of Wearable Inertial Sensors for Sport Performance Evaluation: A Systematic Review
Authors: Camomilla Valentina , Bergamini Elena , Fantozzi Silvia , Vannozzi Giuseppe
Published: March 2018

Recent technological developments have led to the production of inexpensive, non-invasive, miniature magneto-inertial sensors, ideal for obtaining sport performance measures during training or competition. This systematic review evaluates current evidence and the future potential of their use in sport performance evaluation. Articles published in English (April 2017) were searched in Web-of-Science, Scopus, Pubmed, and Sport-Discus databases. A keyword search of titles, abstracts and keywords which included studies using accelerometers, gyroscopes and/or magnetometers to analyse sport motor-tasks performed by athletes (excluding risk of injury, physical activity, and energy expenditure) resulted in 2040 papers. Papers and reference list screening led to the selection of 286 studies and 23 reviews. Information on sport, motor-tasks, participants, device characteristics, sensor position and fixing, experimental setting and performance indicators was extracted. The selected papers dealt with motor capacity assessment (51 papers), technique analysis (163), activity classification (19), and physical demands assessment (61). Focus was placed mainly on elite and sub-elite athletes (59%) performing their sport in-field during training (62%) and competition (7%). Measuring movement outdoors created opportunities in winter sports (8%), water sports (16%), team sports (25%), and other outdoor activities (27%). Indications on the reliability of sensor-based performance indicators are provided, together with critical considerations and future trends.
Validation of the VitaBit Sit–Stand Tracker: Detecting Sitting, Standing, and Activity Patterns
Authors: Berninger Nathalie , Ten Hoor Gill , Plasqui Guy
Published: March 2018

Sedentary behavior (SB) has detrimental consequences and cannot be compensated for through moderate-to-vigorous physical activity (PA). In order to understand and mitigate SB, tools for measuring and monitoring SB are essential. While current direct-to-customer wearables focus on PA, the VitaBit validated in this study was developed to focus on SB. It was tested in a laboratory and in a free-living condition, comparing it to direct observation and to a current best-practice device, the ActiGraph, on a minute-by-minute basis. In the laboratory, the VitaBit yielded specificity and negative predictive rates (NPR) of above 91.2% for sitting and standing, while sensitivity and precision ranged from 74.6% to 85.7%. For walking, all performance values exceeded 97.3%. In the free-living condition, the device revealed performance of over 72.6% for sitting with the ActiGraph as criterion. While sensitivity and precision for standing and walking ranged from 48.2% to 68.7%, specificity and NPR exceeded 83.9%. According to the laboratory findings, high performance for sitting, standing, and walking makes the VitaBit eligible for SB monitoring. As the results are not transferrable to daily life activities, a direct observation study in a free-living setting is recommended.
The Post-Intervention Persistence of Energy Conservation Behaviors: An Evaluation of the ‘Start Green’ Program
Authors: Burns S. , Savan Beth
Published: March 2018

For more than four decades, behavioral intervention programs informed by psychology have been employed to increase pro-environmental behaviors. However, there has been little evidence for the post-intervention durability of target behaviors. The few studies that have conducted such evaluations have found that improvements often return to baseline levels post-intervention. This study evaluated the durability of home energy conservation behaviors before, during, and after a community based multi-technique intervention program, and examined the relationship between behavioral durability and the perceived importance, convenience and family norms of each behavior, as well as generalized pro-conservation decision making. The results show increased frequency in target behaviors that remain elevated seven months post-intervention. While the reported generalization of pro-conservation decision-making consistently increased during the study, perceived importance, convenience, and family norms of target conservation behaviors were largely unaffected. In addition, the few significant alterations in these perceptions were found to be due to increases during the post-intervention period only, indicating that they are not necessary pre-requisites for durable behavior change. These results show that a well designed community based intervention can have direct impacts on target behaviors that persist beyond its termination.