bluuebunny/crossref_metadata_2025 huggingface dataset:
Tibetan red deer (Cervus canadensis wallichi) diet composition patterns and associations during lean seasons in Tibet, China
Authors: Liang Xiaoping , Wei Kaili , Li Qinfang , Gooley Aaron , Zhang Minghai , Yu Jingjing , Wang Zhongbin , Yin Changxiao , Zhang Weiqi
Published: November 2024

Tibetan red deer (Cervus canadensis wallichi) in the high-altitude environment of the Qinghai-Tibet Plateau could face seasonal challenges from food shortages and nutritional deficiencies but the nutritional requirements are complex. Analyzing diet composition pattern(s) is the first step to disentangle this complexity. From a systematic perspective, we hypothesize that: (A) diet composition pattern or patterns exist within the population and (B) a portion of the diet beyond characterized diet combinations will consist of random combinations. In this study, we investigated diet composition patterns of a Tibetan red deer population distributed in the Sangri Red Deer Reserve, Tibet Autonomous Region, during the harsh lean season. In March 2021 and 2022, we searched for Tibetan red deer in the reserve and collected freshly defecated samples. Diet composition at the individual level was determined using micro-histological analysis, followed by k-means clustering and co-occurrence network analysis to reveal population level diet composition patterns. Diet composition of Tibetan red deer included 14 and 19 plant species (or genera) in 2021 and 2022, respectively. K-means clustering indicated two distinct diet patterns within the population across both sampling periods. In 2021, diet composition of both clusters was dominated by Salix spp. (58.49% and 33.67%). In 2022, R. macrophylla had the highest ranking and occupied 34.83% of diet composition in the first cluster while Salix spp. (39.39%) was the most consumed food in the second cluster. Results of co-occurrence networks showed positively associated food combinations of less dominant food items, with a staple food occurring in all food item pairs in both years. However, randomness accounted for 95.83% and 93% of all food item pairs in 2021 and 2022, respectively, which implies a stable dietary complex system. The 2022 co-occurrence network displayed complex associations, while the 2021 network exhibited limited and simple associations. Our results suggest that Tibetan red deer fulfill their nutritional requirements by consuming high quantities of several food items or a balanced combination of foods with complex co-occurrence associations to overcome potential food shortages, but multilayer networks containing nutritional values and food availabilities are necessary to entangle the complexity of the dietary system.
Potential Application of Spices and Pineapple as Healthy Beverages
Authors: Ishak Zuwariah , Maarof Syahida , Mohamad Nur Ilida , Kasim Norzaleha , Noor Nik Mohd Faiz Che Mohd
Published: November 2024

Aims: The purpose of this study was to evaluate pineapple-spice beverages for their potential health benefits and assess their consumer acceptance. Fortifying fruit beverages with spices can enhance their nutritional and health benefits, making them effective carriers for delivering phytochemicals and other nutrients.
Methodology: Spices extracts from cinnamon bark, star anise, coriander, cloves, white cumin, and cumin were incorporated into pineapple beverages to enhance their antioxidant, vitamin, and mineral content. Specifically, two selected samples, namely pineapple-spice beverages and spice beverage (as a control), were chosen based on the optimization of beverage formulation parameters previously conducted.
Results: The formulation deemed most favourable through sensory evaluation comprised 25% pineapple juice combined with spice extracts and underwent further physicochemical analyses and shelf life studies. The shelf life of both beverages demonstrated 12 months of storage stability at ambient temperature, in terms of sensory evaluation, microbiological, and physical analyses. In the 12th month, the sensory evaluation panel for spice beverages and pineapple spice beverages gave scores above 6 for all attributes, which include colour, odour, viscosity, taste, sweetness, sourness, and overall acceptability of the beverages. The highest scores in panellist evaluations were attributed to the pineapple spice beverages. In antioxidant studies, the highest values of DPPH, FRAP value and total phenolic content were observed in samples of pineapple spice beverages. Pineapple-spice beverages (25%) exhibited significant levels of vitamin A, C, B3, B5, B7, B12, and zinc. Colour analysis for the L* value showed a slight increase, while the a* value showed a slight decrease throughout the storage period for both types of beverages. Additionally, pH and brix values were recorded during the storage period of the beverage samples.
Conclusion: Thus, spices and pineapple are an excellent potential for creating nutritious and healthy beverages.
Analysis of Return on Asset and Inflation on Stock Returns in Telecommunication Sector Companies on IDX
Authors: Amin A. Mustika
Published: November 2024

Aims: The primary objective of this study was to assess the impact of return on assets (ROA) and inflation on stock returns for telecoms businesses listed on the IDX from 2019 to 2023.
Study Design:  This research is a quantitative study that intends to investigate the effect of Return on Asset and Inflation on Stock Returns.
Place and Duration of Study: Indonesia Stock Exchange (IDX) between March to October 2024.
Methodology: The research method used is descriptive method with a quantitative approach, with the classical assumption test data analysis method, multiple linear regression analysis and hypothesis testing. The sampling technique in this study was purposive sampling where only 10 of the 16 populations were sampled.
Results: The Sig. result for ROA is 0.010 <0.05 and the t count value is 2.679> t table 2.012, meaning that ROA on variable Stock Return has a significant effect partially, while for inflation it is 0.011> 0.05 and the t count value is 2.657 > t table 2.012 means that Inflation on variable Stock Return does not have a significant effect partially. As for the F test results, the calculated F value is 6.233. While in the distribution table the value of F at a significant level of 5% is 3.195. The significant value is at a value of 0.004> 0.05, it can be concluded that ROA (X1), and inflation (X2) simultaneously have a significant effect on Stock Returns (Y).
Conclusion: Both ROA and Inflation Partially has a negative and significant effect on stock returns. In addition, simultaneously the results showed that ROA and Inflation simultaneously had a significant effect on Stock Returns.
Chaos Theory and Garbage Can Model as Effective Strategies for Decision Making in Educational Institutions
Authors: GÖKSOY Süleyman
Published: November 2024

Chaos is explained as complexity, instability, unpredictability, nonlinearity, and in the trash can model, conflicts, restrictions, differences, dynamic environment, instability of participation, complex organizations, and unstable conditions have importance. The garbage can model explains this tendency in organizations that often experience very high degrees of uncertainty. The aim of the current study is to discuss how the manager can benefit from the trash can model within the framework of their proactive personality in cases of chaos that may occur during the education management process. A case study design from qualitative research methods was used in the study. The research data were obtained, analyzed, evaluated and interpreted with the document analysis technique. The literature on chaos theory and the garbage can model used in administrative decision-making was systematically examined and synthesized. In general, the question sought to be answered is how education and school systems can effectively manage chaos and complexity. Thus, a new and different understanding and perspective will be tried to be created for effective school management.
Within the scope of the current research, the following suggestions can be offered to education administrators: Creating a simple and flexible organization and organizational structure, giving importance to the detection of pre-learning and experiences (cognitive, emotional, motor, social aspects) in individuals, the need for education and school administrators to be proactive and behave accordingly. As a result, in school improvement efforts, despite linear organizational charts and development plans, schools are not linear but chaotic systems. This situation brings about the fact that schools cannot be managed from the top. Also, plans in schools should be short-term (1-2 years) rather than long-term (5-10 years) and should focus on the process rather than the product.
Effect of Nitrogen and Boron Fertilization on Nutrient Content and Uptake by Mustard Crop in Chitrakoot Area
Authors: Mishra Ashutosh , Sirothia Pawan , Waladi Bharti , Singh Opendra Kumar
Published: November 2024

This study assessed the impact of nitrogen (N) and boron (B) fertilization on yield, nutrient composition, and nutrient uptake in Indian mustard (Brassica juncea) in Chitrakoot, Madhya Pradesh, India. A field trial featuring 13 treatments combined reduced nitrogen levels, nano-urea applications, and different boron doses, using a randomized block design with three replications. Treatment T12 [½ recommended nitrogen dose (RDN) + two nano-urea sprays + 1.25 kg B ha⁻¹] achieved the highest seed yield (1523.81 kg ha⁻¹), surpassing the control (100% NPK as per RDF) which yielded 958.73 kg ha⁻¹. T12 also had the highest nutrient concentrations 2.78% nitrogen, 0.482% phosphorus, and 0.74% potassium as well as the highest nutrient uptake, with nitrogen at 42.36 kg ha⁻¹, phosphorus at 7.34 kg ha⁻¹, and potassium at 11.28 kg ha⁻¹. These results indicate that combining nano-urea with boron, especially at elevated boron levels, can significantly improve yield and nutrient absorption in mustard, highlighting its potential for sustainable farming in semi-arid areas.
Effect of Fertilizers and Humic Acids on Soil Micro Nutrients of Foxtail Millet Crop
Authors: Kumar Y. S. Satish , Rao Ch. Sujani , Prasad P. R. K. , Sridhar T.Venkata , Basha S. Jaffar , Jayalalitha K.
Published: November 2024

Humic acids is an important soil component that can improve nutrient availability and impact on other important chemical, biological, and physical properties of soils. The ecological benefits of Humic acids are diverse and represent profitable and effective solutions for environmental problems and preservation of the environment. It can be integrated into the soils in the form of manure; it improves the physico chemical and biological properties of the soil. A field experiment was conducted at the College Farm, Agricultural College, Mahanandi, ANGRAU during kharif & rabi seasons of 2020-21 and 2021-22. The experimental soil was sandy loam in texture with a pH of 7.52, an Electrical Conductivity (EC) of 0.42 dS/m, 0.32% Organic Carbon (OC), low available nitrogen (175 kg ha-1), medium phosphorus (P) at 18.48 kg ha-1, high potassium (K) at 580 kg ha-1, and sufficient zinc (Zn) status at 0.85 ppm. The experiment was laid out in split plot design with three replications with four main plots and six sub plots total twenty four treatments. After critical observation of the study, available iron, Zinc, Copper and Manganese contents in soil revealed that there was significant difference between the subplots that received different levels of Humic acids but main plots that received different levels of inorganic fertilizers and their interaction was found to be non significant at panicle initiation and harvest stages of foxtail millet crop in two kharif seasons of 2020 and 2021. Similar results were recorded in soil Copper and Manganese contents during two kharif seasons of Foxtail millet crop. However, the similar trend was followed in succeeding bengalgram crop.
A Systematic Review of the Impact of Medicinal Plants on Cardiac Health Compared to Standard Pharmaceuticals Available in Bangladesh
Authors: Joty Farhana Akter , Azad Md. A. K.
Published: November 2024

Introduction: Medicinal plants have long been an essential part of healthcare in many cultures with a variety of bioactive chemicals that contribute to different pharmacological effects. Crude medicines, which are frequently utilized in their natural state to treat a variety of ailments, can be derived from these plants. The potential of medicinal plants in medication development and discovery has been acknowledged more and more by contemporary scientific research, especially when it comes to disorders for which there are few available treatments. Numerous chemicals originating from plants have been found to possess antibacterial, anti-inflammatory, antioxidant, and cardioprotective qualities, making them potential candidates for use in pharmaceutical applications.
Aims: The aim of this study is to review and analyze the medicinal plants of Bangladesh that show potential benefits for cardiovascular health. It focuses on evaluating the therapeutic properties of these plants, comparing them with existing pharmaceutical treatments, and emphasizing the importance of further research to explore their effectiveness and possible integration into cardiovascular health management.
Methodology: A systematic review was conducted to identify medicinal plants in Bangladesh with cardiovascular benefits. We searched databases such as PubMed, Scopus, and Google Scholar for studies published between [2006-2019]. The inclusion criteria were studies on plants used in Bangladesh that demonstrate cardiovascular effects, particularly anticoagulant or hypolipidemic properties. Pharmaceutical drugs in the Bangladesh market for similar purposes were also reviewed for comparison. Data were analyzed to highlight the pharmacological effects and potential advantages or drawbacks in comparison to available pharmaceuticals.
Conclusion: Twenty-one medicinal plants have been found to have positive effects on cardiovascular health. On the other hand, despite being effective in their intended pharmacological actions, traditional cardiovascular medications including lipid-lowering medicines and anticoagulants are frequently linked to a variety of adverse effects.
Genetic Association Studies for Indirect Selection for Important Yield and Yield Attributing Traits in Grain Cowpea (Vigna unguiculata L. Walp subsp unguiculata)
Authors: Kundu Ritama , Deshpande Sanjeev K.
Published: November 2024

Aims: The present study encompasses genetic association studies among F4 and F5 families generated from various crosses in grain cowpea (Vigna unguiculata L. Walp subsp unguiculata).
Study Design: Augmented design-II for F4 families and checks during kharif 2023 and Randomized block design with two replications for selected F5 families and checks during rabi-summer 2023-24.
Place and Duration of Study: The current experiment was conducted at the Botany garden, Department of Genetics and Plant Breeding, University of Agricultural Sciences, Dharwad, Karnataka for the evaluation of 36 F4 families and six checks during kharif 2023 and 27 selected F5 families and five checks during rabi-summer 2023-24.
Methodology: The material under experiment included 36 F4 families and six checks evaluated in augmented design-II during kharif 2023. Then during rabi-summer 2023-24, 27 selected F5 families and five checks evaluated in randomized block design. Observations were recorded for nine yield and yield attributing traits viz., total yield (kg/ha), single plant yield (g), number of pods per plant, test weight (g), number of seeds per pod, pod length (cm), number of clusters per plant, days to fifty per cent flowering and days to maturity. Correlation and path coefficients were estimated using standard procedures.
Results: Correlation studies indicated that yield estimates were highly positively correlated to all yield attributing traits except to days to fifty per cent flowering and days to maturity. Characters like number of pods per plant (0.59, 0.64), pod length (0.65, 0.58) and test weight (0.39, 0.58) had highest correlations with yield in F4 and F5 generation respectively. Path coefficients further highlighted the character; number of pods per plant (0.363, 0.594) to have the highest direct effect on yield at both phenotypic and genotypic level respectively.
Evaluation of the Effect of Aqueous Extracts of Fresh Neem (Azadirachta indica A. Juss., 1830) Leaves and Kernels on the Mortality of the Sweet Potato Weevil (Cylas puncticollis Boheman, 1833) under Laboratory Conditions in Burkina Faso
Authors: Rabiéta Simdé , Ouattara Delphine , Alizèta Sawadogo , Elias Mano , Issaka Zida , Karim Nébié , Georges Kambou , Nacro Souleymane
Published: November 2024

Aims: Evaluate the effect of neem extracts (kernels and fresh leaves) on the mortality of the sweet potato weevil Cylas puncticollis in the laboratory.
Place and Duration of Study: The study took place in Bobo-Dioulasso, western Burkina Faso. It lasted for 6 months. 
Methodology: The experimental design was a completely randomized Fisher block in 5 treatments with 5 replicates. The collected fresh neem leaves and kernels were weighed and crushed to which 2.5 l of distilled water was added to each. After 12 hours, the mixture was filtered. Four concentrations were prepared from this filtrate: 10; 20; 30 and 40 cl/l and a control (distilled water). The various tests were carried out with Whatman paper cut into two equal parts then placed at the bottom of a Petri dish and spaced one centimeter apart. One ml of each dose of the solutions prepared was spread evenly on one of the two parts of the paper called the treated area while the other part received nothing called the untreated area. A batch of 10 adult weevils was placed in the center of the paper treated with neem extract.
Results: The results showed that after 1 hour's exposure to neem leaf extracts, a high mortality of 45% was recorded, whereas with neem kernels extracts, 30% mortality was observed after 30 minutes' exposure, then 32.5% after 1 hour.
Conclusion: Neem leaves and kernels extracts can be used to control the potato weevil, Cylas puncticollis. This is an environmentally-friendly control method that could be used as an alternative to chemicals.
Parametric Modeling Method for Rapid Bridge Layout Using BIM Technology: A Revit and Excel Integration Approach
Authors: Zhang Ershi
Published: November 2024

Bridge engineering faces significant challenges and difficulties in applying BIM technology due to its complex structure, changes in component cross-sections, and terrain variations. In building construction projects, elevation and grid are commonly used as the coordinate reference system for buildings, which can help engineers accurately locate various components and parts of the building. However, in bridge engineering, due to the complex changes in road curves and terrain, traditional elevation and grid are no longer applicable in many cases. Therefore, how to achieve parameterized design of component models and rapid and accurate model construction in bridge engineering is an urgent problem that needs to be solved in the engineering field. This article compiles project information of bridge engineering into Excel and uses C # programming language combined with Revit API to extend the functionality of Revit, developing a plugin for rapid parametric modeling of bridge engineering based on "Revit+Excel". This plugin not only significantly improves the modeling efficiency of bridges, saving more than half of the time compared to traditional modeling methods, but also ensures modeling accuracy, thus promoting the application of BIM technology in bridge engineering.
Study On Demand For Service Quality Of Hypermarket
Authors: Chung Yi-Chan , Hsu Yao-Wen , Po Yu-Wei
Published: November 2024

The hypermarket market has reached a saturation point; therefore, hypermarkets should develop their
characteristics and understand customer needs to improve customer satisfaction and attract more customers. This
study uses the Kano model to identify five items that can significantly improve customer satisfaction and reduce
customer dissatisfaction, including staff being willing to assist and Serve customers (Item 4), having a bright and
clean appearance of facilities (Item 7); service facilities meet the requirements Customer needs (Item 9); being able to provide responsible services (Item 20); Staff’s problem-solving attitude builds customer confidence (Item 21). Hypermarkets can improve these items to enhance customer satisfaction and increase profits.
Photoorganocatalytic Aerobic Oxidative Amine Dehydrogenation/Super Acid‐Mediated Pictet‐Spengler Cyclization: Synthesis of cis‐1,3‐Diaryl Tetrahydroisoquinolines
Authors: Unkel Lisa‐Natascha , Malcherek Simon , Schendera Eva , Hoffmann Frank , Rehbein Julia , Brasholz Malte
Published: April 2019

Aerobic oxidative dehydrogenation reactions of benzylamines to imines were studied and the efficiencies of various ground‐ and excited state quinone organocatalysts were compared. Long wave‐absorbing anthraquinones readily catalyze the aerobic photodehydrogenation of primary and secondary benzylamines to benzylidenebenzylamines with high rate and selectivity, and the reaction mechanism was studied by laser flash photolysis. Further, branched α‐benzyl dibenzyl‐amines undergo a regioselective photocatalytic dehydrogenation to branched aldimines, which can efficiently be converted into cis‐1,3‐diaryl tetrahydro‐isoquinolines through diastereoselective super acid‐mediated Pictet‐Spengler cyclizations.

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Synthesis of Multi‐substituted Dihydropyrazoles by Copper‐Mediated [4+1] Cycloaddition Reaction of N‐Sulfonylhydrazones and Sulfoxonium Ylides
Authors: Hu Sipei , Du Shiying , Yang Zuguang , Ni Lingfang , Chen Zhengkai
Published: April 2019

A general and expeditious approach for the copper mediated synthesis of multi‐functionalized dihydropyrazoles from N‐sulfonylhydrazones and sulfoxonium ylides has been achieved under aerobic oxidative conditions. The formal [4+1] cycloaddition reaction exhibits many notable features and can be easily scaled up to gram scale.

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Synthesis of α‐Alkyl‐β‐Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases
Authors: Méndez‐Sánchez Daniel , Mourelle‐Insua Ángela , Gotor‐Fernández Vicente , Lavandera Iván
Published: April 2019

Chiral (α‐substituted) β‐hydroxy amides are interesting derivatives as they are useful building blocks of many biologically active compounds. Herein, the biocatalytic stereocontrolled synthesis of various acyclic syn‐α‐alkyl‐β‐hydroxy amides through a dynamic kinetic resolution is shown. Hence, a series of overexpressed alcohol dehydrogenases (ADHs) in Escherichia coli was used to reduce the corresponding racemic β‐keto amides. Among them, ADH‐A from Rhodococcus ruber and commercial evo‐1.1.200 afforded the best activities and selectivities, giving access to the opposite enantiomers with high diastereomeric excess and excellent enantiomeric excess. Some of these compounds were obtained at semipreparative scale.

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Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi‐Zi‐Hou‐Po decoction in normal and corticosterone‐induced depressive rats
Authors: Bai Yongtao , Song Lihua , Zhang Yongheng , Dai Guoliang , Zhang Weidong , Song Shanshan , Sun Hong , Jing Wen , Xu Meijuan , Ju Wenzheng
Published: April 2019

A highly selective and efficient LC–MS/MS method was developed to determine the plasma concentration of magnolol, hesperidin, neohesperidin and geniposide following oral administration of Zhi‐Zi‐Hou‐Po decoction in normal and depressed rats. Plasma samples were pretreated by protein precipitation with methanol. Chromatographic separation was performed on an XTerra® MS C18 column using a gradient elution with a mobile phase composed of acetonitrile–0.1% aqueous formic acid. The proposed method was validated to be specific, accurate and precise for the analytes determination in plasma samples. The calibration curves displayed good linearity over definite concentration ranges for the analytes. The intra‐ and inter‐day precision of the proposed method at three different levels were all within <11.13% and the relative errors ranged from −8.46 to 8.93%. The recovery of the four compounds ranged from 82.72 to 89.08% and no apparent matrix effect was observed during sample analysis. After full validation, the established method was successfully applied for comparing the pharmacokinetics of four components between normal and depressed rats. The results showed that the AUC and Cmax of four analytes in depressed rats were significantly different from those in normal rats and might provide helpful information to guide the clinical use of Zhi‐Zi‐Hou‐Po to treat depression.
Differences in preferential flow with antecedent moisture conditions and soil texture: Implications for subsurface P transport
Authors: Grant Kirsten N. , Macrae Merrin L. , Ali Genevieve A.
Published: April 2019

Preferential flowpaths transport phosphorus (P) to agricultural tile drains. However, if and to what extent this may vary with soil texture, moisture conditions, and P placement is poorly understood. This study investigated (a) interactions between soil texture, antecedent moisture conditions, and the relative contributions of matrix and preferential flow and (b) associated P distributions through the soil profile when fertilizers were applied to the surface or subsurface. Brilliant blue dye was used to stain subsurface flowpaths in clay and silt loam plots during simulated rainfall events under wet and dry conditions. Fertilizer P was applied to the surface or via subsurface placement to plots of different soil texture and moisture condition. Photographs of dye stains were analysed to classify the flow patterns as matrix dominated or macropore dominated, and soils within plots were analysed for their water‐extractable P (WEP) content. Preferential flow occurred under all soil texture and moisture conditions. Dye penetrated deeper into clay soils via macropores and had lower interaction with the soil matrix, compared with silt loam soil. Moisture conditions influenced preferential flowpaths in clay, with dry clay having deeper infiltration (92 ± 7.6 cm) and less dye–matrix interaction than wet clay (77 ± 4.7 cm). Depth of staining did not differ between wet (56 ± 7.2 cm) and dry (50 ± 6.6 cm) silt loam, nor did dominant flowpaths. WEP distribution in the top 10 cm of the soil profile differed with fertilizer placement, but no differences in soil WEP were observed at depth. These results demonstrate that large rainfall events following drought conditions in clay soil may be prone to rapid P transport to tile drains due to increased preferential flow, whereas flow in silt loams is less affected by antecedent moisture. Subsurface placement of fertilizer may minimize the risk of subsurface P transport, particularily in clay.
Dempster‐Shafer theory‐based hierarchical saliency detection
Authors: Jia Ning , Zhao Weidong , Liu Xianhui
Published: April 2019

This article presents a new saliency detection method based on a hierarchical structure. In order to better capture the key elements in an image, we first construct a three‐layer structure by applying a merging strategy to the image. For different layers, we exploit different methods to detect salient regions. After obtaining initial saliency maps of five layers, we construct a Dempster‐Shafer model to fuse and refine these saliency maps. In the Dempster‐Shafer model, the saliency value of upper layers can provide guidance for saliency detection of lower layers. Finally, we fuse the saliency map of each layer to obtain the final result. Abundant experimental results on two benchmark data sets demonstrate that our method outperforms most of 12 state‐of‐the‐art methods in terms of three popular evaluation criteria, that is, the P‐R curve, the F‐measure, and the mean absolute error.
Identification of lncRNA–miRNA–mRNA regulatory network associated with epithelial ovarian cancer cisplatin‐resistant
Authors: Zhao Xin , Tang Dong‐Yang , Zuo Xu , Zhang Tian‐Dong , Wang Cheng
Published: April 2019

To construct a long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger RNA (mRNA) regulatory network related to epithelial ovarian cancer (EOC) cisplatin‐resistant, differentially expressed genes (DEGs), differentially expressed lncRNAs (DELs), and differentially expressed miRNAs (DEMs) between MDAH and TOV‐112D cells lines were identified. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted to analyze the biological functions of DEGs. Downstream mRNAs or upstream lncRNAs for miRNAs were analyzed at miRTarBase 7.0 or DIANA‐LncBase V2, respectively. A total of 485 significant DEGs, 85 DELs, and 5 DEMs were identified. Protein–protein interaction (PPI) network of DEGs contrains 81 nodes and 141 edges was constructed, and 25 hub genes related to EOC cisplatin‐resistant were identified. Subsequently, a lncRNA–miRNA–mRNA regulatory network contains 4 lncRNAs, 4 miRNAs, and 35 mRNAs was established. Taken together, our study provided evidence concerning the alteration genes involved in EOC cisplatin‐resistant, which will help to unravel the mechanisms underlying drug resistant.
Measuring Anxiety and Depression in Ghanaian and U.S. College Students
Authors: Bettmann Joanna E. , Prince Kort C. , Hardy Clinton J. , Dwumah Peter
Published: April 2019

Differences between Ghanaian (n = 465) and U.S. (n = 425) college students on the Hopkins Symptom Checklist‐25 (HSCL‐25; Mollica, Wyshak, de Marneffe, Khuon, & Lavelle, 1987) were examined. Compared with their U.S. counterparts, Ghanaians reported less general distress related to anxiety and depression, more anxiety‐specific distress, and no differences in depression‐specific distress. A multidimensional approach may be most appropriate in HSCL‐25 screening for symptoms of anxiety and depression.

Se examinaron las diferencias entre estudiantes universitarios ghaneses (n = 465) y estadounidenses (n = 425) en el Listado de Síntomas de Hopkins‐25 (HSCL‐25, por sus siglas en inglés; Mollica, Wyshak, de Marneffe, Khuon, & Lavelle, 1987). Comparados con sus homólogos estadounidenses, los ghaneses comunicaron un menor sufrimiento general relacionado con la ansiedad y depresión, un mayor sufrimiento específico relacionado con la ansiedad, y no hubo diferencias en el sufrimiento específico relacionado con la depresión. Un enfoque multidimensional puede ser el más apropiado en el chequeo de HSCL‐25 para síntomas de ansiedad y depresión.
Drunkorexia: An Exploratory Investigation of College Students With Alcohol‐Related Infractions
Authors: Tuazon Victor E. , Travis Sterling P. , Honderich Eleni M. , Williams Amy E. , Menefee Sarah E. I. , Gressard Charles F.
Published: April 2019

The construct of drunkorexia, caloric restriction prior to or during alcohol consumption, was examined in 411 college students who experienced alcohol‐related infractions. Analyses were conducted to examine differences in demographic prevalence distributions, alcohol‐related consequences, and alcohol consumption between a subsample of participants who reported drunkorexia behaviors and a subsample who did not.
The Impact of Religion/Spirituality on Acculturative Stress Among International Students
Authors: Philip Selin , Neuer Colburn Anita A. , Underwood Lee , Bayne Hannah
Published: April 2019

The authors conducted a qualitative study using phenomenological inquiry to explore the nature and essence of international students' experience of utilizing religion/spirituality to cope with acculturative stress. Twelve students from 2 public universities and diverse religious/spiritual traditions participated. Results suggest that religion/spirituality plays a central role in the heightening of psychological, cognitive, and social functioning and affects students' performance in the academic environment. Implications for student affairs personnel, counselors, counselor educators, and supervisors are provided.
Prior Sexual Victimization and Disclosure of Campus Sexual Violence Among College Students
Authors: Stepleton Kate , McMahon Sarah , Potter Cathryn C. , MacKenzie Michael J.
Published: April 2019

Using survey data from a large, public university, the authors examined the relationships of precollege sexual violence experience to revictimization and disclosure. Among victims of campus sexual violence, those with prior sexual victimization were no more or less likely to disclose to campus resources and were less likely to disclose to peers. Results suggest that institutions need to be prepared to support students with a range of victimization experiences. There is also a need for earlier and expanded sexual violence education and awareness efforts.
Addressing Self‐Injury on College Campuses: Institutional Recommendations
Authors: Lewis Stephen P. , Heath Nancy L. , Hasking Penelope A. , Whitlock Janis L. , Wilson Mark S. , Plener Paul L.
Published: April 2019

Nonsuicidal self‐injury is a significant concern on college campuses. Hence, the authors, the International Consortium on Self‐Injury in Educational Settings, offer the current position paper. First, the authors review current research in the field. Next, they discuss considerations for colleges' institutional‐wide response to self‐injury, including the role of and recommendations for relevant stakeholders (students, residence staff, mental health professionals) who directly and indirectly support students who self‐injure. Guidelines for response and suggested resources are also presented.
Using Narrative Therapy to Assist College‐Age Latino Immigrants
Authors: Farrell Isabel C. , Gibbons Melinda M.
Published: April 2019

Latinos represent a large percentage of the immigrant population currently entering the United States. These immigrants may face mental health issues related to their immigration and acculturation experiences, leading to a need for counseling. The authors introduce narrative therapy as an appropriate treatment modality for college‐age Latino students.
A survey of antimicrobial resistance in Enterobacteriaceae isolated from the Chesapeake Bay and adjacent upper tributaries
Authors: Riedel Stefan , Boire Nicholas , Carson Kathryn A. , Vadlamudi Aravinda , Khuvis Joshua , Vadlamudi Vivek , Atukorale Vajini , Riedel Victoria A. A. , Parrish Nicole M.
Published: April 2019

In recent years, the rise in antimicrobial resistance (AR) in the healthcare setting as well as the environment has been recognized as a growing public health problem. The Chesapeake Bay (CB) and its upper tributaries (UT) is a large and biologically diverse estuary. This pilot study evaluated the presence of AR of gram‐negative bacteria isolated from water samples collected at various sites of the Chesapeake Bay. Bacterial organisms were identified and antimicrobial susceptibility testing was performed by phenotypic and genotypic methods. Ninety‐two distinctly different gram‐negative bacteria were identified; Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, and Escherichia coli were most often isolated. Serratia marcescens was more frequently isolated in samples from the UT compared to the CB. Antimicrobial resistance was more frequently detected in organisms from the CB by phenotypic and genotypic methods. Antimicrobial resistance to ampicillin, imipenem, tetracycline, and chloramphenicol were the most frequently observed resistance patterns. ACT‐1, CMY, and SHV genes were the most frequently detected resistance genes, with predominance in organism isolated from the CB. The results from this study emphasize the importance for further developing comprehensive surveillance programs of AR in bacterial isolates in the various environments, such as recreational and other water systems.
The emergence of melatonin in oncology: Focus on colorectal cancer
Authors: Gil‐Martín Emilio , Egea Javier , Reiter Russel J. , Romero Alejandro
Published: April 2019

Within the last few decades, melatonin has increasingly emerged in clinical oncology as a naturally occurring bioactive molecule with substantial anticancer properties and a pharmacological profile optimal for joining the currently available pharmacopeia. In addition, extensive experimental data shows that this chronobiotic agent exerts oncostatic effects throughout all stages of tumor growth, from initial cell transformation to mitigation of malignant progression and metastasis; additionally, melatonin alleviates the side effects and improves the welfare of radio/chemotherapy‐treated patients. Thus, the support of clinicians and oncologists for the use of melatonin in both the treatment and proactive prevention of cancer is gaining strength. Because of its epidemiological importance and symptomatic debut in advanced stages of difficult clinical management, colorectal cancer (CRC) is a preferential target for testing new therapies. In this regard, the development of effective forms of clinical intervention for the improvement of CRC outcome, specifically metastatic CRC, is urgent. At the same time, the need to reduce the costs of conventional anti‐CRC therapy results is also imperative. In light of this status quo, the therapeutic potential of melatonin, and the direct and indirect critical processes of CRC malignancy it modulates, have aroused much interest. To illuminate the imminent future on CRC research, we focused our attention on the molecular mechanisms underlying the multiple oncostatic actions displayed by melatonin in the onset and evolution of CRC and summarized epidemiological evidence, as well as in vitro, in vivo and clinical findings that support the broadly protective potential demonstrated by melatonin.
Reflexive periodic solutions of general periodic matrix equations
Authors: Hajarian Masoud
Published: April 2019

Analysis and design of linear periodic control systems are closely related to the periodic matrix equations. The objective of this paper is to provide four new iterative methods based on the conjugate gradient normal equation error (CGNE), conjugate gradient normal equation residual (CGNR), and least‐squares QR factorization (LSQR) algorithms to find the reflexive periodic solutions (X1,Y1,X2,Y2,…,Xσ,Yσ) of the general periodic matrix equations

urn:x-wiley:mma:media:mma5596:mma5596-math-0001
for i = 1,2,…,σ. The iterative methods are guaranteed to converge in a finite number of steps in the absence of round‐off errors. Finally, some numerical results are performed to illustrate the efficiency and feasibility of new methods.
Pointwise error estimates for a generalized Oseen problem and an application to an optimal control problem
Authors: Allendes Alejandro , Campaña Gilberto , Hernández Erwin
Published: April 2019

We derive pointwise error estimates for a generalized Oseen when it is approximated by a low order Taylor‐Hood finite element scheme in two dimensions. The analysis is based on estimates for regularized Green's functions associated with a generalized Oseen problem on weighted Sobolev spaces and weighted interpolation results. We apply the maximum norm results to obtain convergence in an optimal control problem governed by a generalized Oseen equation and present a numerical example that allows us to show the behavior of the error.
Preconditioned iterative methods for diffusion problems with high‐contrast inclusions
Authors: Gorb Yuliya , Kramarenko Vasiliy , Kuznetsov Yuri
Published: April 2019

This paper is concerned with robust numerical treatment of an elliptic PDE with high‐contrast coefficients, for which classical finite‐element discretizations yield ill‐conditioned linear systems. This paper introduces a procedure by which the discrete system obtained from a linear finite element discretization of the given continuum problem is converted into an equivalent linear system of the saddle‐point type. Three preconditioned iterative procedures—preconditioned Uzawa, preconditioned Lanczos, and preconditioned conjugate gradient for the square of the matrix—are discussed for a special type of the application, namely, highly conducting particles distributed in the domain. Robust preconditioners for solving the derived saddle‐point problem are proposed and investigated. Robustness with respect to the contrast parameter and the discretization scale is also justified. Numerical examples support theoretical results and demonstrate independence of the number of iterations of the proposed iterative schemes on the contrast in parameters of the problem and the mesh size.
Profiling and simultaneous quantitative determination of oligostilbenes in Paeonia ostii seed shell from different geographical areas in China and their comparative evaluation
Authors: Zhang Lina , Liu Pu , Gao Jiayu , Wang Xinsheng , An Jiamin , Xu Shijing , Deng Rui‐xue
Published: April 2019

Introduction

The Paeonia ostii T. Hong & J. X. Zhang seed shell, characterised by a high content of oligostilbenes, is one of the two most important by‐products in the preparation of seed oil. Oligostilbenes are considered characteristic constituents of the genus Paeonia, and can be used in fingerprinting to determine the geographical origin and the quality of raw materials.

Objective

To develop and optimise a simple and reproducible high‐performance liquid chromatography diode array detection (HPLC‐DAD) method for the simultaneous determination of seven oligostilbenes in P. ostii seed shell from different geographical areas, and to associate the cultivation area.

Methodology

A validated HPLC method coupled with a DAD detector was performed for the detection and determination of target compounds in the samples. Optimal chromatographic conditions were achieved using an Agilent Zorbax Eclipse SB‐AQ‐C18 column and a gradient elution with acetonitrile and potassium dihydrogen phosphate solution.

Results

The proposed quantitative method showed appropriate accuracy and precision, and was successfully applied to the routine analysis of seven oligostilbenes and the quality evaluation of 50 P. ostii seed shell samples. There were significant differences between the contents of the seven oligostilbenes in different samples (P < 0.01).

Conclusion

The results demonstrated that the oligostilbenes were main secondary metabolites in the P. ostii seed shells, and the content of seven components in P. ostii seed shells sourced from different cultivation areas in China was different.
Development of a robotics platform for automated multi‐ionization mass spectrometry
Authors: Karki Santosh , Meher Anil K. , Inutan Ellen D. , Pophristic Milan , Marshall Darrell D. , Rackers Kevin , Trimpin Sarah , McEwen Charles N.
Published: April 2019

Rationale

Successful coupling of a multi‐ionization automated platform with commercially available mass spectrometers provides improved coverage of compounds in complex mixtures through implementation of new and traditional ionization methods. The versatility of the automated platform is demonstrated through coupling with mass spectrometers from two different vendors. Standards and complex biological samples were acquired using electrospray ionization (ESI), solvent‐assisted ionization (SAI) and matrix‐assisted ionization (MAI).

Methods

The MS™ prototype automated platform samples from 96‐ or 384‐well plates as well as surfaces. The platform interfaces with Thermo Fisher Scientific mass spectrometers by replacement of the IonMax source, and on Waters mass spectrometers with additional minor source inlet modifications. The sample is transferred to the ionization region using a fused‐silica or metal capillary which is cleaned between acquisitions using solvents. For ESI and SAI, typically 1 μL of sample solution is drawn into the capillary tube and for ESI slowly dispensed near the inlet of the mass spectrometer with voltage placed on the delivering syringe barrel to which the tubing is attached, while for SAI the sample delivery tubing inserts into the inlet without the need for high voltage. For MAI, typically, 0.2 μL of matrix solution is drawn into the syringe before drawing 0.1 μL of the sample solution and dispensing to dry before insertion into the inlet.

Results

A comparison study of a mixture of angiotensin I, verapamil, crystal violet, and atrazine representative of peptides, drugs, dyes, and herbicides using SAI, MAI, and ESI shows large differences in ionization efficiency of the various components. Solutions of a mixture of erythromycin and azithromycin in wells of a 384‐microtiter well plate were mass analyzed at the rate of ca 1 min per sample using MAI and ESI. In addition, we report the analysis of bacterial extracts using automated MAI and ESI methods. Finally, the ability to perform surface analysis with the automated platform is also demonstrated by directly analyzing dyes separated on a thin‐layer chromatography (TLC) plate and compounds extracted from the surface of a beef liver tissue section.

Conclusions

The prototype multi‐ionization automated platform offers solid matrix introduction used with MAI, as well as solution introduction using either ESI or SAI. The combination of ionization methods extends the types of compounds which are efficiently ionized and is especially valuable with complex mixtures as demonstrated for bacterial extracts. While coupling of the automated multi‐ionization platform to Thermo and Waters mass spectrometers is demonstrated, it should be possible to interface it with most commercial mass spectrometers.
An evaluation of effort estimation supported by change impact analysis in agile software development
Authors: Tanveer Binish , Vollmer Anna Maria , Braun Stefan , Ali Nauman bin
Published: April 2019

In agile software development, functionality is added to the system in an incremental and iterative manner. Practitioners often rely on expert judgment to estimate the effort in this context. However, the impact of a change on the existing system can provide objective information to practitioners to arrive at an informed estimate. In this regard, we have developed a hybrid method, that utilizes change impact analysis information for improving effort estimation. We also developed an estimation model based on gradient boosted trees (GBT). In this study, we evaluate the performance and usefulness of our hybrid method with tool support and the GBT model in a live iteration at Insiders Technologies GmbH, a German software company. Additionally, the solution was also assessed for perceived usefulness and understandability in a study with graduate and post‐graduate students. The results from the industrial evaluation show that the proposed method produces more accurate estimates than only expert‐based or only model‐based estimates. Furthermore, both students and practitioners perceived the usefulness and understandability of the method positively.