bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome
Authors: Vinicki Martina , Pribić Tea , Vučković Frano , Frkatović-Hodžić Azra , Plaza-Andrades Isaac , Tinahones Francisco , Raffaele Joseph , Fernández-García José Carlos , Lauc Gordan
Published: October 2024

With aging, the body’s ability to maintain regular functions declines, increasing susceptibility to age-related diseases. Therapeutic interventions targeting the underlying biological changes of aging hold promise for preventing or delaying multiple age-related diseases. Metformin, a drug commonly used for diabetes treatment, has emerged as a potential gerotherapeutic agent due to its established safety record and preclinical and clinical data on its anti-aging effects. Glycosylation, one of the most common and complex co- and post-translational protein modifications, plays a crucial role in regulating protein function and has been linked to aging and various diseases. Changes in immunoglobulin G (IgG) glycosylation patterns have been observed with age, and these alterations may serve as valuable biomarkers for disease predisposition, diagnosis, treatment monitoring, and overall health assessment. In this study, we analyzed the IgG glycosylation patterns of white men from Europe, aged 29–45 years, under treatment with metformin, testosterone, metformin plus testosterone, and placebo (trial registration number NCT02514629, 2013/07/04), and investigated the longitudinal changes in glycosylation over time. We observed statistically significant differences in the IgG glycome composition between participants on testosterone therapy and placebo, with decreased agalactosylation and increased galactosylation and sialylation. However, metformin therapy did not result in statistically significant changes in glycosylation patterns. These findings contribute to our understanding of the impact of therapeutic interventions on IgG glycosylation and confirm the value of IgG glycosylation as a significant biomarker, capable of assessing biological age using the GlycanAge index and providing insight into overall health compared to chronological age.
Domestication of wild-growing Turkey tail mushroom (Trametes versicolor) from Ethiopian forests on augmented agro-industrial byproducts
Authors: Desisa Buzayehu , Muleta Diriba , Jida Mulissa , Dejene Tatek , Goshu Abayneh , Negi Tadesse , Martin-Pinto Pablo
Published: October 2024

Despite being extensively studied as a white-rot fungus, there have been no efforts to explore and cultivate the high-yielding wild Trametes versicolor strains in Ethiopia. Thus, this study was initiated to assess the growth performance of T. versicolor on various growth media. Accordingly, ten substrates (S1–S10) were formulated by a combination of agro-industrial by-products that mainly constituted sugarcane wastes and animal manures. The effect of substrates on yields, biological efficiencies, and nutritional compositions was examined. The mushroom developed a white mycelium on the growth media. T. versicolor cultivated on the S5 blend, comprising 80% sugarcane bagasse, 12% horse manure, and 8% poultry manure, exhibited the most substantial fruiting body yield (158.33 g/500 g bag) and the highest biological efficiency (31.5%), with an optimal C:N ratio of 31:1. It has shown good mycelial growth, short colonization, and short pinhead formation time compared to other substrates. S7, lacking nitrogen supplementation, yielded low biological efficiency and fruiting bodies at 11.50% and 57.67%, respectively. The crude protein, fiber, low fat, and carbohydrate content ranged from 7.46 to 14.65%, 12.89 to 18.38%, 0.42 to 0.53%, and 48.75 to 66.75%, respectively. Notably, the highest nutritional values, excluding carbohydrates, were obtained from S5, while the sugarcane bagasse had the highest carbohydrate content among substrates. Consequently, S5 emerged as a suitable medium for cultivating wild T. versicolor mushrooms, particularly in regions abundant in poultry, horse manures, and sugarcane bagasse. Therefore, S5 represents an optimal substrate for T. versicolor cultivation, offering improved productivity and nutritional quality at reduced costs.
Discovery and characterization of novel lipopeptides produced by Virgibacillus massiliensis with biosurfactant and antimicrobial activities
Authors: Essghaier Badiaa , Naccache Chahnez , Ben-Miled Houda , Mottola Filomena , Ben-Mahrez Kamel , Mezghani Khemakhem Maha , Rocco Lucia
Published: October 2024

The study aimed to evaluate the biosurfactants (BSs) production by SM-23 strain of Virgibacillus identified by phenotypical and WGS analysis as Virgibacillus massiliensis. We first demonstrated the lipopeptides production by Virgibacillus massiliensis specie and studied their biochemical and molecular analysis as well as their biological potential. The GC–MS analysis indicated that methyl.2-hyroxydodecanoate was the major fatty acid compound with 33.22%. The maximum BSs production was obtained in LB medium supplemented by 1% olive oil (v/v) at 30 °C and 5% NaCl with 1.92 g/l. The obtained results revealed the significant biosurfactants/bioemulsifier potential compared to triton X100 with E24 of 100%, and an emulsification stability SE of 83%. The lipopeptides types were identified by FTIR analysis. A strong antimicrobial action was observed by the produced lipopeptides by the agar diffusion method against E.coli, K. pneumoniae, S. aureus, Fusarium sp, Alternaria sp, and Phytophtora sp. The complete genome sequencing showed genes involved in the synthesis of multiple compounds identified as amphipathic cyclic lipopeptides such as locillomycin/locillomycin B/locillomycin C and bacillibactin. Our results highlighted significant lipopeptides properties displayed by V. massiliensis that can be exploited to develop a novel strategy in the formulation of natural biocidal and fungicidal agents.
Prediction of surgical benefit in gastric cancer patients with peritoneal metastasis treated with hyperthermic intraperitoneal chemotherapy
Authors: Jin Shiyang , Wei Yuzhe , Wang Qiancheng , Ju Yuming , Wang Zeshen , Cheng Qingqing , Li Zhenglong , Liu Xirui , Wang Kuan
Published: October 2024

The objective is to evaluate whether gastric cancer patients with peritoneal metastasis can benefit from surgery through a comprehensive analysis of different clinical factors and perioperative treatment methods. A total of 135 gastric cancer patients with peritoneal metastasis were treated with Hyperthermic intraperitoneal chemotherapy (HIPEC). Patients were divided into either training group (without surgery, n = 90) or test group (with surgery, n = 45). A nomogram was constructed based on significant prognostic factors. The patients were divided into high- and low-risk groups using a nomogram. Overall survival were then compared according to whether surgery was performed in both groups. Alpha-fetoprotein (AFP), complications, conversion chemotherapy, and postoperative chemotherapy were significantly associated with overall survival (p < 0.05). A nomogram was constructed using the above four factors and validated using the test set. The area under the curve (AUC) of the model was 0.752 (95% CI 0.525–978). In the group that did not undergo surgery, the median survival times for the high-risk and low-risk groups were 7 and 11 months, respectively. In the surgery group, the median survival times for the high-risk and low-risk groups were 11 and 19 months, respectively. The difference was statistically significant (p < 0.0001). The four-factor nomogram can accurately predict high-risk and low-risk populations. Our findings suggest that cytoreductive surgery combined with HIPEC can improve the survival time of patients in both groups.
Self-identified Race and Ethnicity and How this is Perceived: Associations with the Physical and Mental Health of Incarcerated Individuals
Authors: Zajdel Rachel A. , Patterson Evelyn J. , Rodriquez Erik J. , Webb Hooper Monica , Pérez-Stable Eliseo J.
Published: October 2024

Objectives

The singular focus on self-identified race and ethnicity in health disparities research may not fully convey the individual and structural components of experiencing race in society, or in a racialized context such as prison. Processes of racialization create boundaries between incarcerated individuals and regulate their daily interactions and access to resources, with possible effects on well-being. However, the relationship between perceived race and health has not been examined within the imprisoned population.

Design

We used data from the 2016 Survey of Prison Inmates (n = 23,010) to assess how self-identified race, perceived race, and the discordance between racial self-identification and perception were associated with the physical (number of chronic conditions) and mental health (psychological distress) of American Indian and Alaska Native, Asian, Black, Latino, White, and multiracial incarcerated individuals.

Results

Reported perception as Latino was associated with better mental and physical health relative to perception as White. Perceived Latino identity was more strongly associated with physical and mental health than a Latino self-identity. Reported perception as Black was associated with less psychological distress than perception as White, but this relationship dissipated after accounting for self-identified race. In contrast, perceived and self-identified multiracial incarcerated individuals reported worse health than their White counterparts. Having a discordant (vs. concordant) racial identity was associated with worse physical and mental health among imprisoned persons regardless of race.

Conclusion

The use of a single, unidimensional measure of race and ethnicity in health disparities research does not fully reveal racialization’s influence on health, specifically for those experiencing incarceration.
High Fe-Loading Single-Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy
Authors: Chen Si , Huang Fang , Mao Lijie , Zhang Zhimin , Lin Han , Yan Qixin , Lu Xiangyu , Shi Jianlin
Published: October 2024

The current single-atom catalysts (SACs) for medicine still suffer from the limited active site density. Here, we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with iron. The constructed iron SACs (h3-FNC) with a high metal loading of 6.27 wt% and an optimized adjacent Fe distance of ~ 4 Å exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial effects. Attractively, a “density effect” has been found at a high-enough metal doping amount, at which individual active sites become close enough to interact with each other and alter the electronic structure, resulting in significantly boosted intrinsic activity of single-atomic iron sites in h3-FNCs by 2.3 times compared to low- and medium-loading SACs. Consequently, the overall catalytic activity of h3-FNC is highly improved, with mass activity and metal mass-specific activity that are, respectively, 66 and 315 times higher than those of commercial Pt/C. In addition, h3-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion (O2·−) and glutathione (GSH) depletion. Both in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h3-FNCs in promoting wound healing. This work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.
Social Class: Te Mātaiaho | the New Zealand Curriculum Refresh’s ‘Inconvenient Truth’?
Authors: Estellés Marta , Rozas-Gómez Claudia , Morgan John , Shafer Derek
Published: October 2024

In this paper, we connect with Martin Thrupp’s calls for class-based analysis in education policy by problematising the absence of social class in the refreshed New Zealand curriculum, Te Mātaiaho (2023). To contextualise this absence, we locate this curriculum policy in a historical perspective and interpret its ‘identity turn’ as an expression of what philosopher Nancy Fraser calls ‘progressive neoliberalism’. We conclude our contribution with a reflection on the reactionary neoliberal response of the current National-led government and a call for educational researchers in Aotearoa New Zealand to more seriously consider social class in their analyses.
Visualizing Convergent Pressures on Arctic Development
Authors: Rivera Ana , Stephenson Scott R. , Tingstad Abbie
Published: October 2024

A rapidly changing Arctic has impacted biophysical and human systems while creating new economic opportunities. Spatially identifying locations with development potential in this changing environment requires characterizing convergences in critical enabling/constraining factors occurring in a particular place. However, mapping techniques based on simple overlays of spatially heterogeneous data may result in visual clutter, compromising legibility, and increasing the likelihood of interpretation errors. To overcome these limitations, we introduce Pythia, a tool that combines geographic statistical analysis with a subtractive color model to enable bi- or tri-variate data analysis. Three case studies showcase this visualization tool. Case study 1 identifies locations where temperature and population are projected to increase by 2040. Case study 2 reveals locations with a significant presence of major roads and high NO2 concentrations but few hospitals and clinics. In case study 3, a combination of transportation infrastructure, protected areas, and travel and tourism infrastructure signals challenges for the future Alaskan tourism industry. Comparing these results allows for further geographic characterization of locations, aiding policymakers in identifying areas lacking resources and infrastructure, exploring possible futures, and supporting long-term strategic planning.
4D Track Reconstruction on Free-Streaming Data with PANDA at FAIR
Authors: Taylor Jenny , Papenbrock Michael , Stockmanns Tobias , Kliemt Ralf , Johansson Tord , Akram Adeel , Schönning Karin ,   the PANDA Collaboration
Published: October 2024

A new generation of accelerator-based experiments in subatomic physics is being developed, where the challenge of separating rare signal processes from background at high intensities requires a change of trigger paradigm. At the future PANDA experiment at FAIR, hardware triggers will be abandoned and instead a purely software-based system will be used. This requires novel reconstruction methods with the ability to process data from many beam–target interactions simultaneously. A 4D tracking algorithm, based on the cellular automaton, has been developed which will utilize the timing information from detector signals. Simulation studies have been performed to test its performance on the foreseen free-streaming, i.e., continuous readout from the PANDA detector, where all processing is on the software level. For this purpose, a novel quality assurance method, tailored for tracking on free-streaming data has been developed and implemented. Benchmark studies on PANDA software show that at higher interaction rates, 4D tracking performs better than the 3D algorithm in terms of efficiency, 84$$\%$$
%
compared to 77$$\%$$
%
. In addition, the fake track suppression is greatly improved, reducing the rate of fake tracks of “ghosts” by about 50$$\%$$
%
.
A rough set-based model for predicting soil greenhouse gases response to biochar
Authors: Belmonte Beatriz A. , Flores Jesus Gabriel A. , Mestizo Cristine L. , Rafer Patricia Nicole B. , Benjamin Michael Francis D. , Aviso Kathleen B. , Tan Raymond R.
Published: October 2024

Biochar application to soil is a potential climate change mitigation strategy. In addition to long-term sequestration of the carbon content of the biochar itself, its application may reduce the emissions of other greenhouse gases (GHGs) from the soil. However, the reported effects of biochar application on soil GHG fluxes exhibit inconsistent results. Prediction of such effects is an important gap that needs to be addressed in biochar research. In this study, rule-based machine learning models were developed based on rough-set theory. Data from the literature were used to generate the rules for predicting the effects of biochar application on soil GHG (CO2, N2O, and CH4) fluxes. Four rule-based models for CO2 fluxes, two rule-based models for N2O fluxes, and three rule-based models for CH4 fluxes were developed. The validity of these models was assessed based on both statistical measures and mechanistic plausibility. The final rule-based models can guide the prediction of changes in soil GHG fluxes due to biochar application, and thus serve as a decision-support tool to maximize the benefits of biochar application as a negative emission technology (NET). In particular, mechanistically plausible rules were identified that predict triggers for GHG fluxes that can offset carbon sequestration gains. This knowledge allows biochar application to be calibrated to local conditions for maximum efficacy.

Graphical Abstract
The importance of urine protein-to-creatinine ratio in elderly patients receiving angiogenesis inhibitors
Authors: Sonoda Akihiro , Iwashita Yoshitaka , Setoguchi Makoto , Kodama Mayo , Shibata Yukina , Hamazono Ryu , Ishida Kazuhisa , Yanagi Masayuki , Imamura Hiroshi
Published: October 2024

Background

Patients receiving angiogenesis inhibitor treatment require attention regarding proteinuria. Monitoring proteinuria using the urine protein-to-creatinine ratio (UPCR) is critical. However, the utility of the UPCR for administering angiogenesis inhibitors to elderly patients remains unclear.

Objectives

We retrospectively examined whether UPCR measurements are associated with improved efficacy and safety of angiogenesis inhibitors in elderly patients.

Methods

This study included patients who experienced grade 2 or higher proteinuria at least once after the administration of angiogenesis inhibitors. The UPCR values at which bevacizumab and ramucirumab could be administered were defined to be less than 3.5 and 2.0, respectively. The actual total dose/planned total dose was used as an efficacy indicator. A proteinuria rate of grade 2 or higher was used as a safety indicator.

Results

There were 14 patients in both the UPCR and qualitative test groups. The medians of the actual total dose/planned total dose (%) for the angiogenesis inhibitors in the UPCR and qualitative test groups were 96.8 (48.5–103.9) and 77.7 (9.1–93.1), respectively, with that in the UPCR group being significantly higher (p < 0.001). However, one patient in the UPCR group developed nephrotic syndrome.

Conclusions

Monitoring UPCR in elderly patients with grade 2 or higher proteinuria increases the total dosage of angiogenesis inhibitors, which may enhance their therapeutic effects. However, nephrotic syndrome was not fully confirmed in this small-scale study. Although further safety verifications are needed, our findings highlight the importance of monitoring UPCR to improve the efficacy and safety of angiogenesis inhibitors in elderly patients.
Hudson Medal Lunch
Authors: Achiume E. Tendayi , Anghie Antony
Published: October 2024

I just want to congratulate Tony Anghie for winning the Society's highest award. And I cannot think of a better person to engage in a conversation with Tony than Tendayi Achiume. Thank you so much for agreeing to do this.
The Goler T. Butcher Medal Lecture: Chanting Their Names
Authors: Sellers Patricia Viseur
Published: October 2024

Thank you to the ASIL Selection Committee, the Annual Meeting Co-Chairs, President Gregory Shaffer, and Executive Director Michael D. Cooper for presenting me with the 2023 Goler T. Butcher Medal. I gratefully use this wonderful occasion to present a lecture to ASIL members.
A large-scale particle system with independent jumps and distributed synchronization
Authors: Baryshnikov Yuliy , Stolyar Alexander
Published: October 2024

We study a system consisting of n particles, moving forward in jumps on the real line. Each particle can make both independent jumps, whose sizes have some distribution, and ‘synchronization’ jumps, which allow it to join a randomly chosen other particle if the latter happens to be ahead of it. The system state is the empirical distribution of particle locations. We consider the mean-field asymptotic regime where

$n\to\infty$

. We prove that

$v_n$

, the steady-state speed of advance of the particle system, converges, as

$n\to\infty$

, to a limit

$v_{**}$

which can easily be found from a minimum speed selection principle. Also we prove that as

$n\to\infty$

, the system dynamics converges to that of a deterministic mean-field limit (MFL). We show that the average speed of advance of any MFL is lower-bounded by

$v_{**}$

, and the speed of a ‘benchmark’ MFL, resulting from all particles initially being co-located, is equal to

$v_{**}$

. In the special case of exponentially distributed independent jump sizes, we prove that a traveling-wave MFL with speed v exists if and only if

$v\ge v_{**}$

, with

$v_{**}$

having a simple explicit form; we also show the existence of traveling waves for the modified systems with a left or right boundary moving at a constant speed v. We provide bounds on an MFL’s average speed of advance, depending on the right tail exponent of its initial state. We conjecture that these results for exponential jump sizes extend to general jump sizes.
A study of one-factor copula models from a tail dependence perspective
Authors: Shyamalkumar Nariankadu , Tao Siyang
Published: October 2024

Modeling multivariate dependence in high dimensions is challenging, with popular solutions constructing multivariate copula as a composition of lower dimensional copulas. Pair-copula constructions do so by using bivariate linking copulas, but their parametrization, in size, being quadratic in the dimension, is not quite parsimonious. Besides, the number of regular vines grows super-exponentially with the dimension. One parsimonious solution is factor copulas, and in particular, the one-factor copula is touted for its simplicity – with the number of parameters linear in the dimension – while being able to cater to asymmetric non-linear dependence in the tails. In this paper, we add nuance to this claim from the point of view of a popular measure of multivariate tail dependence, the tail dependence matrix (TDM). We focus on the one-factor copula model with the linking copula belonging to the BB1 family, pointing out later the applicability of our results to a wider class of linking copulas. For this model, we derive tail dependence coefficients and study their basic properties as functions of the parameters of the linking copulas. Based on this, we study the representativeness of the class of TDMs supported by this model with respect to the class of all possible TDMs. We establish that since the parametrization is linear in the dimension, it is no surprise that the relative volume is zero for dimensions greater than three, and hence, by necessity, we present a novel manner of evaluating the representativeness that has a combinatorial flavor. We formulate the problem of finding the best representative one-factor BB1 model given a target TDM and suggest an implementation along with a simulation study of its performance across dimensions. Finally, we illustrate the results of the paper by modeling rainfall data, which is relevant in the context of weather-related insurance.
Risk of SARS-CoV-2 infection in hospitalized patients following SARS-CoV-2 exposures before and during hospitalization
Authors: Ehrenzeller Selina , Agan Anna , Rhee Chanu , Klompas Michael
Published: October 2024

Little is known regarding SARS-CoV-2 infection risk following SARS-CoV-2 exposures in hospitalized patients. Amongst 11,997 patients in 14 hospitals exposed 2020–2023, 6.5% tested positive (median 3d after exposure). Positivity rates were 6.7% vs 5.8% for Omicron vs pre-Omicron exposures (P = 0.07) and 7.6% vs 4.6% for exposures before vs after admission (P < 0.001).
Inviscid jets driven by pressure maxima
Authors: Ockendon J.R. , Ockendon H.
Published: October 2024

Recent numerical calculations have revealed the existence of fast jets in inviscid fluids when a pressure maximum exists close to a free boundary. This paper describes two-dimensional and axisymmetric configurations for which asymptotic analysis suggests that such jets can become infinitely long in finite time.
Reparation for non-recent institutional child sexual abuse in England and Wales and Australia: a matter for private law or the state?
Authors: Giliker Paula
Published: October 2024

This paper examines the question of reparation for non-recent institutional child sexual abuse in England and Wales and Australia in the light of independent inquiries which reported in 2022 (England and Wales) and 2017 (Australia). Both inquiries recommended the introduction of state-based redress schemes that would exist alongside private law. While the new UK government considers how to proceed, Australia has established a national redress scheme, there have been changes to private law and new legislation reforming tort law and removing procedural obstacles such as limitation. In evaluating the Australian reforms and the case for change in English law, this paper examines the different roles state-based redress and private law compensation play in responding to the harm suffered by victims and survivors of sexual abuse. It argues that there are urgent lessons that the UK government should learn from the Australian experience in establishing a redress scheme and that while legislative change to substantive private law has proven less than successfull in Australia, legislation on limitation periods and suing unincorporated associations has assisted plaintiffs. Finally there are lessons that private law can learn from state-based redress schemes in seeking to provide remedies that meet the distinctive needs of victims and survivors of child sexual abuse.
Chronological considerations for the use of the Late Roman–Migration period Cemetery at Plinkaigalis, Lithuania
Authors: Orozco Alexandria R , Kurila Laurynas , Micelicaitė Viktorija , Jankauskas Rimantas , Branting Scott , Gutautas Simonas , Robkin Jessica R , Whalen Annalise , Atabas Atakan
Published: October 2024

This study presents new (n=32) and previously published (n=35) human bone 14C AMS dates from 54 individuals interred in 50 burials in the Plinkaigalis cemetery (3rd–7th century AD, Lithuania). The aim of this study is to establish duration of use and identify temporal subgroups within the cemetery. Individuals in group burials were assessed for temporal agreement across individuals and the dates for individuals with multiple dates were combined using OxCal. The Sum command, Interval command, and two Bayesian models (overlapping and abutting periods of use) were used to approximate the use of the site over time and evaluate the chronology of dated burials. An IDW (inverse distance weighted) model was employed to visualize median radiocarbon dates across the cemetery for comparison to earlier IDW interpolations of time at Plinkaigalis. While the two models cannot be distinguished at this time, it can be determined that the site was likely in continuous use from 200–600 cal AD (Sum), 230–560 cal AD (Model 1), 220–550 cal AD (Model 2), or cal 283–508 AD (IDW). The area of the cemetery associated with earliest use shifted east when the IDW model was compared to original data. There was also poor agreement in some group burials and burials with multiple dates. The models generally agree on assignment of burials to phases, but disparate phase assignment was noted across the IDW and Bayesian models. Temporal subgroups cannot be confidently reclassified beyond early/later periods of use based on these models without additional sampling and refinement of the IDW modeling method.
A burning issue: Spirits of land and capital in Thailand's agricultural haze crisis
Authors: Cassaniti Julia
Published: October 2024

Air pollution created by agricultural burning has become a critical environmental problem across Southeast Asia, but the solution to it remains unclear. In this essay I discuss the haze crisis in a small community in Northern Thailand, and show how an increase in contract farming is accompanied by a decrease in agricultural spirit rituals. I argue that this change represents a broader shift in the cosmopolitical ecology of the region, as large agricultural businesses hide behind continuing narratives about ‘slash-and-burn’ ‘hill tribes’ to advance an environmentally unsustainable agenda.
Transnationalising Malay Cinema: P. Ramlee in Hong Kong
Authors: Yeo Min Hui
Published: October 2024

This article investigates P. Ramlee's little-known attempt at transnationalising Malay cinema in the early 1960s. Using biographical records, newspaper reports and film magazines, I trace the star's earliest direct contact with Hong Kong cinema, his plans to make Malay films in Hong Kong, the controversy that ensued, and the outcomes of these grand plans. Situating this episode in its historical context, this article unsettles standard narratives of P. Ramlee, and Malay and Malaysian film histories. It demonstrates that, as opposed to the seemingly inevitable ethnonational route, and in contrast to the hypernationalist characterisation of P. Ramlee today, a transnational model was once envisioned through P. Ramlee as a potential future for Malay cinema in the face of tumultuous geopolitical changes. It also brings to light the complex role that labour activism played in shaping post-studio era development of Malay cinema, and the roots of Malaysian national cinema.
At the intersection of history and biography: French retirees in Cambodia and Laos
Authors: Raffin Anne
Published: October 2024

Scholars studying international retirement migration (IRM) refer to lifestyle migration to explain the motives and aspirations of older individuals who choose to relocate out of their home country. Here I investigate French retirees’ reasons for migrating to Southeast Asia, and their sense of purpose in doing so. Interviews with 17 retirees living in Sihanoukville, Cambodia, and Vientiane, Laos, whose narratives evoked some degree of historical relevance, suggest that certain migration choices are best understood in the context of a postcolonial moment comprising colonialism and its dissolution, the Cold War, and the postcolonial diaspora. Such an approach illuminates the relationship between history, migration, and pensioners’ respective biographies in explaining their retirement journeys to former colonies, and in how these experiences foster multifaceted hybrid identities embedded in various historical moments.
Cicchetti’s organizational-developmental perspective of Down syndrome: Contributions to the emergence of developmental psychopathology and the study of persons with neurodevelopmental conditions
Authors: Burack Jacob A. , Russo Natalie , Evans David W. , Boatswain-Jacques Anna-Francesca , Rey Gabriela , Iarocci Grace , Hodapp Robert M.
Published: October 2024

Dante Cicchetti’s earliest work, his studies of social-emotional development in infants and children with Down syndrome, set the stage for the emergence of the larger field of developmental psychopathology. By applying basic developmental principles, methodologies, and questions to the study of persons with Down syndrome, Dante took on the challenge of searching for patterns in atypical development. In doing so, he extended traditional developmental theory and introduced a more “liberal” approach that both continues to guide developmentally based research with persons with neurodevelopmental conditions (NDCs), including Down syndrome. We highlight five themes from Dante’s work: (1) appreciating the importance of developmental level; (2) prioritizing the organization of development; (3) examining whether developmental factors work similarly in those with known genetic conditions; (4) rethinking narratives about ways of being; and (5) examining the influence of multiple levels of the environment on the individual’s functioning. We highlight ways that these essential lessons anticipated present-day research with persons with a variety of NDCs, including Down syndrome, other genetic syndromes associated with intellectual disability, and autism. We conclude with visions to the future for research with these populations as well as for the field of developmental psychopathology more generally.
Intergenerational transmission of comorbid internalizing and externalizing psychopathology at age 11: Evidence from an adoption design for general transmission of comorbidity rather than homotypic transmission
Authors: Marceau Kristine , Lee Sohee , Datta Muskan , Robertson Olivia C. , Shaw Daniel S. , Natsuaki Misaki N. , Leve Leslie D. , Ganiban Jody M. , Neiderhiser Jenae M.
Published: October 2024

Psychopathology is intergenerationally transmitted through both genetic and environmental mechanisms via heterotypic (cross-domain), homotypic (domain-specific), and general (e.g., “p-factor”) pathways. The current study leveraged an adopted-at-birth design, the Early Growth and Development Study (57% male; 55.6% White, 19.3% Multiracial, 13% Black/African American, 10.9% Hispanic/Latine) to explore the relative influence of these pathways via associations between adoptive caregiver psychopathology (indexing potential environmental transmission) and birth parent psychopathology (indexing genetic transmission) with adolescent internalizing and externalizing symptoms. We included composite measures of adoptive and birth parent internalizing, externalizing, and substance use domains, and a general “p-factor.” Age 11 adolescent internalizing and externalizing symptom scores were the average of adoptive parent reports on the Child Behavior Checklist (n = 407). Examining domains independently without addressing comorbidity can lead to incorrect interpretations of transmission mode. Therefore, we also examined symptom severity (like the “p-factor”) and an orthogonal symptom directionality score to more cleanly disentangle transmission modes. The pattern of correlations was consistent with mostly general transmission in families with youth showing comorbid internalizing and externalizing symptoms, rather than homotypic transmission. Findings more strongly supported potential environmental or evocative mechanisms of intergenerational transmission than genetic transmission mechanisms (though see limitations). Parent-specific effects are discussed.
Childhood language development and alexithymia in adolescence: an 8-year longitudinal study
Authors: Lee Ka Shu , Catmur Caroline , Bird Geoffrey
Published: October 2024

Alexithymia (difficulties identifying and describing feelings) predicts increased risks for psychopathology, especially during the transition from childhood to adolescence. However, little is known of the early contributors to alexithymia. The language hypothesis of alexithymia suggests that language deficits play a primary role in predisposing language-impaired groups to developing alexithymia; yet longitudinal data tracking prospective relationship between language function and alexithymia are scarce. Leveraging data from the Surrey Communication and Language in Education cohort (N = 229, mean age at time point 1 = 5.32 years, SD = 0.29, 51.1% female), we investigated the prospective link between childhood language development and alexithymic traits in adolescence. Results indicated that boys with low language function at ages 4–5 years, and those who later met the diagnostic criteria for language disorders at ages 5–6 years, reported elevated alexithymic traits when they reached adolescence. Parent-reported child syntax abilities at ages 5–6 years revealed a dimensional relationship with alexithymic traits, and this was consistent with behavioral assessments on related structural language abilities. Empirically derived language groups and latent language trajectories did not predict alexithymic traits in adolescence. While findings support the language hypothesis of alexithymia, greater specificity of the alexithymia construct in developmental populations is needed to guide clinical interventions.
Community-engaged research: Bringing the science of developmental psychopathology into the real world
Authors: Parade Stephanie H. , Jennings Ernestine , Huffhines Lindsay , Rojo-Wissar Darlynn M. , Caron Colleen , Berger Blythe , Stroud Laura R. , Tyrka Audrey R.
Published: October 2024

The science of developmental psychopathology has made outstanding progress over the past 40 years in understanding adaptive and maladaptive developmental processes across the life span. Yet most of this work has been researcher driven with little involvement of community partners in the research process, limiting the potential public health significance of our work. To continue to advance the field we must move beyond the physical and conceptual walls of our research laboratories and into the real world. In this article, we define and describe the importance of community-engaged research, and present our overarching principles for engaging the community including practicing respect, shared power and decision-making, prioritizing the needs of the community, and engaging in consistent and transparent communication. We present several associated recommendations for best practice and highlight examples from our own research that is grounded in a developmental psychopathology perspective to illustrate these practices. Recommendations for the future of the discipline of development and psychopathology, with emphasis on training and continuing education, are described.
Profiles of self-regulation and their association with behavior problems among sexually abused children
Authors: Amédée Laetitia Mélissande , Cyr Chantal , Hébert Martine
Published: October 2024

This study aimed to delineate profiles of self-regulation among sexually abused children and their association with behavior problems using a person-centered approach. A sample of 223 children aged six to 12, their parents, and teachers were recruited in specialized intervention centers. Latent profile analysis revealed four profiles: (1) Dysregulated, (2) Inhibited, (3) Flexibly Regulated, and (4) Parent Perceived Self-Regulation. Children from the Flexibly Regulated profile showed relatively low behavior problems, and those from the Dysregulated profile were characterized by high behavior problems. Children from the Parent Perceived Self-Regulation profile showed overall good adaptation, although teachers reported higher behavior problems than parents. Children from the Inhibited profile, characterized by the highest level of inhibition but low parent-rated emotion regulation competencies and executive functions, showed the highest level of internalizing behavior problems, indicating that high inhibition does not necessarily translate to better adaptation. Results also show a moderation effect of sex. Being assigned to the Inhibited profile was associated with decreased externalizing behaviors in boys and increased internalizing behaviors in girls. This study underscores the complexity of self-regulation in sexually abused children and supports the need to adopt a multi-method and multi-informant approach when assessing these children.
Snake queens and political consolidation: How royal women helped create Kaan: A view from Waka’
Authors: Navarro-Farr Olivia C. , Kelly Mary Kate , Freidel David A.
Published: October 2024

Classic Maya history was rife with shifting political coalitions and disputes with the key antagonists, Tikal and the Kaan regime, at the center. Understanding how power dynamics and political shifts were experienced among subordinate polities is best viewed from multiple perspectives. We employ elements of Graeber and Sahlins' (2017) stranger-king model, focusing on exogamous marriage practices in relation to two Snake Queens ruling at Waka’. They served as direct links between the Kaan regime and the subordinate Wak polity. We focus on the political and diplomatic nature of their roles in crafting Waka's place in the overarching narratives of alliance and conquest during the sixth through the early part of the eighth centuries. The pairing of archaeological and textual data surrounding Ix Ikoom in the sixth century and Lady K'abel during the seventh century permit interrogation of women's prominence with respect to Kaan regime-building strategies during these centuries.
Psychometric properties of the Turkish version of the developmental care scale for neonates with congenital heart disease
Authors: Sevgi Seçkin Kolak , Ayşe Kahraman
Published: October 2024

Objective:

Developmental care for newborns with congenital heart disease (CHD) improves cardiac and respiratory patterns. According to the American Heart Association, developmental care in newborns with CHD is important for improving neurodevelopmental outcomes. This study aimed to evaluate the validity and reliability of the Turkish version of the Developmental Care Scale for Neonates with Congenital Heart Disease.

Methods:

This was a methodological, descriptive study conducted with 169 nurses from a tertiary-level NICU. The Demographical Information Form and the Developmental Care Scale for Neonates with Congenital Heart Disease were used to collect the data. The scales’ language and content validity, construct validity, and internal consistency were also assessed.

Results:

The scale consists of 31 items and four subscales. Factor loadings ranged from 0.44 to 0.82 and explained 65% of the total variance. Fit indices indicate that the model is acceptable. Cronbach’s α was 0.95 for the entire instrument, 0.91 for developing the external environment subscale, 0.94 for assessing family well-being, 0.86 for the caregiver activities toward the neonate, and 0.82 for the basic need subscale. Item–total correlations ranged between 0.34 and 0.75, according to the item analysis results.

Conclusions:

The Turkish version of the Developmental Care Scale for Neonates with Congenital Heart Disease is valid and reliable. The use of this scale could improve the performance of neonatal intensive care nurses in providing developmental care to newborns with CHD as well as the quality of care.
Defenders of Liberty: The Congos and the Question of African Agency in the Haitian Revolution
Authors: Mobley Christina
Published: October 2024

In April 1802, the leaders of the Haitian Revolution faced a choice that would expose fundamental differences in their vision of liberty in post-emancipation society: join General Leclerc's army or continue the fight against French expeditionary forces. Henri Christophe, Toussaint Louverture, and Jean Jacques Dessalines agreed, whilst Kongo leader Macaya and Sans-Souci refused, the latter describing his forces as “defenders of liberty.”1 Following his arrest, Louverture famously declared: “In overthrowing me, you have cut down in Saint Domingue only the trunk of the tree of the liberty of the blacks; it will grow back from the roots, because they are deep and numerous.”2 The most obvious roots of liberty were Sans-Souci's mainly African troops, known as the “Congos,” who continued the revolution using tactics honed in 1791. But when Christophe, Dessalines, and Alexandre Pétion defected from the French and joined the newly-united “indigenous army,” the conflict over who would lead the “defenders of liberty” persisted, culminating in Henri Christophe's assassination of Sans-Souci, after whom he would famously name his palace.3 Sans-Souci's death foreshadowed a broader discursive victory in post-revolution historiography, which celebrated the role of Creole and mixed-race leaders, and the political ideology of the French Revolution, to the exclusion of African people and ideas.4
Concurrent validity of inertial measurement units in range of motion measurements of upper extremity: A systematic review and meta-analysis
Authors: Li Jinfeng , Qiu Fanji , Gan Liaoyan , Chou Li-Shan
Published: October 2024

Inertial measurement units (IMUs) have proven to be valuable tools in measuring the range of motion (RoM) of human upper limb joints. Although several studies have reported on the validity of IMUs compared to the gold standard (optical motion capture system, OMC), a quantitative summary of the accuracy of IMUs in measuring RoM of upper limb joints is still lacking. Thus, the primary objective of this systematic review and meta-analysis was to determine the concurrent validity of IMUs for measuring RoM of the upper extremity in adults. Fifty-one articles were included in the systematic review, and data from 16 were pooled for meta-analysis. Concurrent validity is excellent for shoulder flexion–extension (Pearson’s r = 0.969 [0.935, 0.986], ICC = 0.935 [0.749, 0.984], mean difference = −3.19 (p = 0.55)), elbow flexion–extension (Pearson’s r = 0.954 [0.929, 0.970], ICC = 0.929 [0.814, 0.974], mean difference = 10.61 (p = 0.36)), wrist flexion–extension (Pearson’s r = 0.974 [0.945, 0.988], mean difference = −4.20 (p = 0.58)), good to excellent for shoulder abduction–adduction (Pearson’s r = 0.919 [0.848, 0.957], ICC = 0.840 [0.430, 0.963], mean difference = −7.10 (p = 0.50)), and elbow pronation–supination (Pearson’s r = 0.966 [0.939, 0.981], ICC = 0.821 [0.696, 0.900]). There are some inconsistent results for shoulder internal–external rotation (Pearson’s r = 0.939 [0.894, 0.965], mean difference = −9.13 (p < 0.0001)). In conclusion, the results support IMU as a viable instrument for measuring RoM of upper extremity, but for some specific joint movements, such as shoulder rotation and wrist ulnar-radial deviation, IMU measurements need to be used with caution.
Projecting Future Mercury Emissions From Global Biofuel Combustion Under the Carbon Neutrality Target
Authors: Wang Tengjiao , Xin Yu , Du Huarui , Cui Can , Li Jiashuo , Liu Xi
Published: October 2024

Biomass plays a crucial role in the low‐carbon energy transition, with a projected contribution of 18.7% to the global energy supply by 2050. However, biofuel combustion has been a notable source of toxic mercury emissions, yet the future trends and distribution of the emissions remain inadequately understood. Here, we projected biofuel combustion under various Shared Socioeconomic Pathways (SSPs) using the Global Change Assessment Model and assessed associated mercury emissions in cooking, heating, and power generation over 2020–2050, aligning with the carbon neutrality target. Our analysis reveals that global biofuel mercury emissions are projected to be 9.90–18.40 tons by 2050, compared to the annual emissions of 13.89 tons in 2020. Notably, a substantial increase in emissions from power generation is expected, escalating from 0.57 tons in 2020 to 4.69–8.27 tons by 2050, with China and Southeast Asia emerging as primary contributors. Conversely, mercury emissions from cooking and heating are expected to decrease from 13.32 tons in 2020 to 4.40–11.53 tons by 2050, except in Africa under SSP2, where the emissions may increase from 5.91 to 6.69 tons. Our findings provide a scientific basis for policies aimed at achieving carbon neutrality targets while adhering to the Minamata Convention on Mercury.