bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular epidemiological investigation and genetic variation analysis of porcine reproductive and respiratory syndrome virus
Authors: Li Zhiliang
Published: October 2024

Porcine reproductive and respiratory syndrome (PRRSV) is a reproductive disorder and respiratory infectious disease of pigs caused by virus (PRRSV). Its clinical characteristics are fever and anorexia in sows, abortion in late pregnancy, and easy to give birth to stillbirth; Piglets with respiratory symptoms and increased mortality before weaning, commonly known as blue-ear disease, can also cause immunosuppression, infection and other diseases immune failure. The constant variation of PRRSV has caused huge economic losses to China’s pig industry chain.
A Taxonomy of Knowledge Management Systems
in the Micro-Enterprise
Authors: J. Hall Stephen , Smith Serengul , Baskent Can , De Raffaele Clifford
Published: October 2024

Knowledge Management Systems enhance innovation, increase operational efficiency, and improve decision-making in business organisations. The administrative and resource overheads required to implement and maintain such systems inherently exclude the smallest of firms from reaping these benefits. This research aims to identify, evaluate, and summarize the distribution of research on knowledge management and supporting systems across business size classifications with a particular focus on micro-enterprises. It also seeks to establish if existing knowledge management models, practices, and systems have invested due consideration in their design to cater for the limited resources typically found in the micro-enterprise. It contributes new insight into the applicability of knowledge management systems to micro-enterprises and it stimulates a possible re-think of how such systems can cater to the specific constraints of this prolific business type. This taxonomy is the result of a thorough analysis of 168 research papers from a total of 10511 papers published in reputable conference proceedings since 2012. It focuses on key knowledge management themes covered, including the size of the enterprise, the adoption challenges, the potential benefits, the technologies used, and the aspects of the knowledge management cycle that are being employed. Furthermore, it draws on this analysis to highlight the appropriateness of existing knowledge management systems to the distinctive risk and opportunity characteristics of the micro-enterprise.
Sultan’ın Mutlakıyeti ve Müttefikleri: Nizam-ı Cedid Dönemi Üzerine Bir İnceleme
Authors: Yılmaz Sercan
Published: October 2024

Türkiye’nin son 250 yıllık değişim ve dönüşüm tarihinin bütünü modernleşme-batılılaşma paradigması içinde kavranılmaktadır. Nizam-ı Cedid hareketi de batılılaşmanın ve batı kurumlarının Osmanlı toplum ve devlet hayatına tesirinin başlangıcı olarak ele alınmasıyla programlı bir modernleşme hareketi olarak görülmektedir. Böylece ilgili dönemin, İmparatorluğun klasik döneminin anlam-değer kabulleri ve tavırlarından keskin bir dönüşümü ihata ettiği varsayılmaktadır. Bu çalışmada ise Nizam-ı Cedid ile ortaya çıkan reform sürecinin Osmanlı İmparatorluğu’nun klasik döneminin siyasal ideolojisi ile gösterdiği bütünlüklü ilişkinin mahiyeti ortaya konulmaktadır. Bu dönemin ana karakteri, reform siyaseti aracılığıyla sultanın mutlakıyeti tekrar kurulurken, bu çabanın Osmanlı siyasası içindeki müttefikleriyle birlikte oluşturmak istediği yapının doğurduğu siyasal gerilimlere dayanmaktadır. Dolayısıyla bu döneme modernleşme üzerinden atfedilen ilerici-gerici, aydın-muhafazakâr dikotomileri oturduğu retoriğin, klasik dönemin siyasal ideolojisinden kopmanın değil, Osmanlı siyasasının kendi içindeki mevzi çatışmalarının siyasal söylemi içinde anlam kazandığı görülmektedir. Böylece Nizam-ı Cedid dönemi, İmparatorluğun klasik ile yeni arasında kurmaya çalıştığı dengeli ilişkide kendine özgü bir dönüşüm siyasetinin takip edildiği bir dönem olarak ortaya çıkmaktadır.
Samsun’da Kara Yolu Trafik Kazalarının CBS Tabanlı Zamansal ve Mekânsal Analizi
Authors: Özçelebi Muhammed Akif
Published: October 2024

Dünya genelinde kentlerdeki araç sayısının artışı, uluslar için önemli bir endişe kaynağı olmuştur. Bu durum, ekonomik kayıpların yanı sıra kara yolu trafik kazalarında (KTK) da yükselişe yol açmış ve trafik güvenliğini küresel düzeyde ciddi bir sorun haline getirmiştir. Bu çalışmada Samsun’da KTK’lerin zaman içerisinde neden ve nasıl gerçekleştiğinin tespit edilmesi, nispeten yüksek riskli konumların belirlenmesi ve yakın çevresindeki aktivite alanlarıyla ilişkilendirilmesi amaçlanmıştır. Bu doğrultuda Çekirdek yoğunluk, Ancelin Local Moran’ın I, benzerlik ve mekân-zaman küpü analizlerinden yararlanılmıştır. Buna göre 2018-2020 yılları arasında gerçekleşen 4.339 kara yolu trafik kazaları en az perşembe günü, kış mevsimi ve gece saatlerinde (00.00-06.00) meydana gelirken, en fazla kaza ise cumartesi günü, yaz ayları ve akşam vakitlerinde (16.00-21.00) gerçekleşmiştir. Çalışma kapsamında yapılan analizler Samsun’da KTK’lerin daha yüksek araba hızına ve hacmine sahip çok şeritli yollar üzerinde kümelendiğini ortaya çıkarmıştır. KTK’lar konut ve ticari arazi kullanım alanları ile kamu ve özel kurumların toplandığı şehir merkezleri ve yakın çevresindeki anayollar boyunca meydana gelmiştir. KTK’lerde sözü edilen şehir merkezlerinde ise Samsun’un en nüfuslu ilçesi olan İlkadım öne çıkmıştır. Samsun şehrinde mekân zaman küpü analizi neticesinde zaman içinde KTK’lerin kümelenme gösterdiği sıcak noktalar içerisinde en geniş alana yayılan model “azalan sıcak noktalar” olmuştur. Bu model İlkadım ilçesinin kentsel alanı ile Canik ilçesinin batısındaki İlkadım Bulvarı’nın çevresinde kümelenmiştir. Sonuç olarak tespit edilen bu sıcak noktalar güvenlik kurumlarının kaza sıklığını veya şiddetini azaltacak önlemler konusunda daha bilinçli kararlar almasına rehberlik edeceği düşünülmektedir.
Gümüşhane Merkez Mahalle Adlarının Köken Bakımından İncelenmesi
Authors: Budak Nihan
Published: October 2024

Yer adları bilimi (toponimi) dilbilimin alt dallarından biridir. Yer adları; coğrafi şartlar, toplum ve toplumun sahip olduğu kültür, yaşam şekilleri ve şartlarıyla doğru orantılı olarak oluşmaktadır. Yer adlarından hareketle coğrafi yapının yanı sıra o bölgede yaşayan toplum hakkında da ipuçları vermektedir. Bu çalışmada Türkiye’nin kuzeydoğusunda yer alan illerden biri olan Gümüşhane ele alınacaktır. Altı ilçesi bulunan bu ilin merkezi Merkez ilçesi olarak adlandırılmaktadır. Merkez ilçeye bağlı 20 mahalle bulunmaktadır. Bu mahallelerin 8 tanesinin adı tek kelimeden, diğerleri ise iki kelimeden oluşmaktadır. Bu çalışmada mahallelerin adları yapıları ve kökenleri bakımından tek tek ve alfabetik sırayla incelenecektir. Böylelikle dilbilimin alt alanlarından biri olan ve yer adlarının oluşumunu ve anlamını inceleyen yer ad bilimi (toponimi/toponomi) alanına katkı sağlamak amaçlanmaktadır. Tek kelimeden oluşan mahalle adları Canca Mahallesi, Çamlıca Mahallesi, Ekinciler Mahallesi, Fatih Mahallesi, Gaziler Mahallesi, Mezire Mahallesi, Süleymaniye Mahallesi, Yeni Mahallesi; iki kelimeden oluşan mahalle adları Akçakale Mahallesi, Bağlarbaşı Mahallesi, Esentepe Mahallesi, Eskibağlar Mahallesi, Hacıemin Mahallesi, Hasanbey Mahallesi, İnönü Mahallesi, Karaer Mahallesi, Karşıyaka Mahallesi, Oltanbey Mahallesi, Osman Gazi Mahallesi, Özcan Mahallesi şeklindedir.
AEIOU: ARQUITETURA EMERGENTES, INSURGÊNCIAS E OUTROS URBANISMOS
Authors: Carmo Julio Cesar Botega , Weingartner Gutemberg dos Santos , Tsuha Amanda Yumi
Published: October 2024

Será apresentando relato de experimentação de caráter extensionista, por meio do urbanismo tático, voltado para a ativação urbana da área da Esplanada Ferroviária em Campo Grande, Mato Grosso do Sul.
A SUSTENTABILIDADE COMO PILAR NO PLANO DE DESENVOLVIMENTO INSTITUCIONAL DA UNIFIMES E A TRANSVERSALIDADE COM ENSINO, PESQUISA, EXTENSÃO E INOVAÇÃO
Authors: Rezende Cunha Juliene , Salvador Alves de Oliveira Evandro , Lage Fonseca Prado Roselaine , Resende Freitas Daniel , Pereira Glicélia , De Sá Fernandes Marilaine
Published: October 2024

O artigo analisa a sustentabilidade como pilar estratégico de Plano de Desenvolvimento Institucional. Usando análise documental, destaca-se a integração com ensino, pesquisa e extensão, concluindo que a sustentabilidade fortalece o desenvolvimento regional e institucional.
IMPACTO DA EXTENSÃO UNIVERSITÁRIA NA SUSTENTABILIDADE E INOVAÇÃO
Authors: Costa Jacundá Mylena , Morais da Costa Jeferson , Batista Vicente Kyldes
Published: October 2024

O presente artigo analisa o impacto da extensão universitária na promoção da sustentabilidade e inovação, com foco na análise do projeto "Conectando Ideias," desenvolvido pela Universidade Estadual do Tocantins (UNITINS). A pesquisa explora como ações de extensão, baseadas em metodologias participativas, podem fomentar o empreendedorismo e a inovação em comunidades do Tocantins com baixos Índices de Desenvolvimento Humano Municipal (IDHM). O projeto "Conectando Ideias" integrou teoria e prática, promovendo atividades que incentivaram a ciência, a tecnologia e a criatividade, contribuindo para o desenvolvimento socioeconômico regional. A análise destaca o papel transformador da extensão universitária quando alinhada às políticas públicas e aos Objetivos de Desenvolvimento Sustentável (ODS), evidenciando sua capacidade de criar redes colaborativas e de engajar diversos públicos, incluindo estudantes, professores e membros da comunidade. Os resultados obtidos demonstram que o projeto não apenas aumentou o interesse por temas de inovação tecnológica e empreendedorismo, mas também fortaleceu a capacidade das comunidades locais de se envolverem em atividades sustentáveis e inovadoras. O sucesso do projeto "Conectando Ideias" reafirma a relevância da extensão universitária como um pilar estratégico para o desenvolvimento regional, mostrando que iniciativas bem planejadas e executadas podem gerar impactos significativos e duradouros, contribuindo para a construção de um futuro mais equitativo e sustentável no Estado do Tocantins.
Suicide in LGBTI (Lesbian, Gay, Bisexual, Transgender, Intersex) Individuals
Authors: Alaçam Elçin , Yılmaz Mualla
Published: October 2024

Although lesbian, gay, bisexual, transgender, and intersex (LGBTI) people have become more visible in recent years, in many countries, people with different sexual orientations continue to face discrimination, exclusion, labeling, violence, fines, and death penalties. Individuals with different sexual orientations are subjected to homophobic attitudes that are considered not only by society but also by their closest social environment, such as family. Homophobia within the family can lead to a loss of self-confidence, self-esteem and negative situations such as migration and homelessness. In addition to the difficulties they experience, their inability to benefit from health services negatively affects their mental health. Studies show that the rates of suicide among LGBTI people are higher than among heterosexuals due to difficulties and mental problems. In order to reduce the suicide risk of individuals with different sexual orientations, the lack of knowledge of society and healthcare professionals should be eliminated. LGBTI individuals should be supported in the coming out process, and school-family-health worker cooperation should be ensured due to the higher risk of suicide during adolescence. Preventive interventions should be prioritized, and the cultural competencies of healthcare professionals should be gained in order to determine whether individuals who commit suicide were previously receiving psychological support in some of the studies conducted. Training should be organized for health professionals to gain cultural competencies, courses for those with different sexual orientations should be added to the curriculum, and care guidelines should be created. This review aims to address the factors in suicidal behaviors of those with different sexual orientations and the strategies that can be implemented to address these factors. It is thought that this review can be used as a resource for creating training and care guidelines, which are essential factors in gaining future cultural competencies of healthcare professionals.
Neuropsychiatric Problems of Patients Undergoing Neurosurgery
Authors: Albayrak Eda , Topan Handan , Sürme Yeliz
Published: October 2024

Patients undergoing neurosurgery for various medical conditions often experience a range of physiological and neuropsychiatric challenges. Common complications include fear, anxiety, depression, post-traumatic stress disorder, delirium, and sleep disorders, especially prevalent among individuals treated surgically for brain tumors. These neuropsychiatric symptoms can lead to extended hospital stays, increased rates of mortality and morbidity, and a decline in overall functional outcomes. Effective management requires a comprehensive approach that includes thorough evaluation, targeted psychoeducation, and consistent counseling. By providing holistic care that integrates psychological and physiological needs, healthcare professionals can support patients in navigating the emotional and cognitive impact of their surgical experience. Telehealth practices offer a promising avenue to extend monitoring and support beyond the hospital, allowing continuous care that enhances patients' quality of life and reduces the risk of disability, while also providing valuable resources for their families.
Self Psychology and Mood Disorder
Authors: Kesebir Sermin
Published: October 2024

The self is the state of feeling and experiencing the existence of the subject called “me”. The self is a fragmented self in the newborn. The first part is called the “demonstrative/grandiose self”. When appropriately mirrored and supported by the caregiver, it provides vitality and self-esteem, in other words, a sense of existence. The second part, in which the object of the self is projected, is called the 'idealized parental image'. When the idealized parental image is properly developed in the relationship between the self and the self-object, it provides a balance in tension, the ability to wait/defer and impulse control. While the psychology of the self was initially associated with the concept of narcissism, it has subsequently been used to explain depression. Our findings suggest that self-pathology and mood disorders overlap electrophysiologically. This calls for further investigation of the structural etiology of mood disorder, in other words, whether psychopathology of the self is a predisposing trait for mood disorder.
Social Media Addiction and Lie Concept from a Psychological Perspective
Authors: Deligöz Eda
Published: October 2024

The act of lying is considered a multidimensional and complex problem that is shaped by cognitive and social factors underlying individuals' behaviors and has important social consequences in society. Lying may be triggered by factors such as personal gain, desire for social acceptance, desire to maintain social relations, or it may be based on psychological and psychopathological foundations. With the rapid development of digital technologies and the widespread use of social media platforms, individuals' efforts to exist in the virtual environment have increased their tendency to distort the truth in order to make themselves more attractive or interesting. While social media allows individuals to interact with other users continuously, it also creates an atmosphere of competition that can be called “social competition” in this environment. This situation triggers behaviors such as making themselves look different than they are, exaggerating their achievements or living conditions, and makes it easier to lie on these platforms. The increasing tendency to lie in social media posts can also affect individuals' mental health and psychological states. As the dissonance between online identities and real-life selves increases, individuals may develop depression, anxiety disorders and even narcissistic tendencies. Thus, the proliferation of lying on digital platforms is not only an individual problem, but also carries risks for the mental health of society. The aim of this study is to draw attention to the relationship between social media addiction and lying and to discuss how social media addiction may increase the tendency to lie in individuals in the light of scientific studies in the existing literature.
El Rol de la Salud Mental en el Plan de Salud Pública 2022-2031: Desafíos y Oportunidades
Authors: Manrique Abril Fred Gustavo , Herrera Amaya Giomar Maritza , Suárez Parra Adriana Marcela
Published: October 2024

Introducción: El Plan Decenal de Salud Pública 2022-2031 de Colombia es una construcción colectiva y significativa para mejorar la salud pública y garantizar el derecho fundamental a la salud, especialmente en los aspectos de salud mental y atención a poblaciones vulnerables. Reconoce en la salud, un derecho humano inalienable y define al bienestar integral como físico y mental. El plan establece objetivos estratégicos para mejorar la calidad de vida, reducir desigualdades y asegurar la participación social en la formulación de políticas.
Metodología: Revisión narrativa teniendo como inicio de profundización, los puntos clave sobre la incorporación de la salud mental como un objetivo esencial, la importancia de la colaboración interinstitucional y el fortalecimiento de los servicios de salud.
Resultados:  Se describen las estrategias relevantes sobre la gestión de determinantes sociales, la capacitación de personal de salud, y el monitoreo continuo para ajustar las intervenciones según sea necesario.
Conclusiones:  Se recalcan los desafíos para la implementación que consisten en el abordaje de las desigualdades en acceso a servicios, el estigma asociado a la salud mental, y la sostenibilidad financiera. Se puntualiza sobre las oportunidades importantes del plan como son un marco legal favorable, la participación social activa y la innovación tecnológica, que pueden mejorar el acceso a la salud mental, especialmente en áreas rurales.
Discusión y Recomendaciones: El Plan Decenal 2022-2031 es un paso fundamental hacia un sistema de salud que responda a la necesidad urgente de ofrecer una cobertura completa, equitativa e inclusiva. La participación activa de la comunidad y la intersectorialidad son componentes cruciales en la toma de decisiones ya que fortalece las posibilidades de éxito en la implementación de estrategias adaptadas a las necesidades reales de cada región, permitiendo reducir las inequidades y mejorar el bienestar general de la población.
Cardio-metabolic disorders in a patient with non-alcoholic fatty liver disease and normal body weight
Authors: Turkina Svetlana V. , Statsenko Mikhail E. , Tyshchenko Irina A. , Titarenko Marina N. , Kosivtsova Marina A. , Gorbacheva Elena E.
Published: October 2024

The relationship between the formation of non-alcoholic fatty liver disease (NAFLD) in obese individuals has been proven, which increases the patient’s cardio-metabolic risk. A number of studies have demonstrated that patients with normal body weight (NBW) have comparable risks of developing cardiovascular disease and progression to NAFLD compared to obese patients.
Purpose of the study: To assess the incidence of cardio-metabolic disorders in patients with NAFLD and NBW.
Materials and methods: 225 patients of both sexes (18–65 years old) with confirmed NAFLD were included. Patients were divided into 3 groups according to body mass index (BMI) values.
Results: In patients of group 1, an increased risk of developing coronary heart disease (CHD), arterial hypertension (AH), type 2 diabetes mellitus and progression of liver fibrosis was revealed with an increase in the level of the triglyceride index.
Conclusions: The study demonstrated the need for early identification of NAFLD in NBW individuals and assessment of existing cardiometabolic risk factors.
Laparoscopic surgery and mortality in perforated peptic ulcer (correlation and regression
Authors: Puzikova Alla V. , Panin Stanislav I. , Linchenko Alexander A. , Bublikov Alexander E.
Published: October 2024

Aim of the study is to evaluate the relationship between the number of laparoscopic operations and mortality in patients with perforated peptic ulcer.
Materials and methods: The functional relationships between the number of performed laparoscopic operations and the levels of hospital and postoperative mortality were studied based on the analysis of the results of surgical treatment of patients with a perforated ulcer in 2018.
Results: An analysis of the functional relationships between the number of laparoscopic operations performed and mortality was carried out based on the results of primary statistical information (2 189 patients with a perforated ulcer). Strong direct correlations have been established, which can be most reliably described within the framework of polynomial regression models (r2 = 0.917 and r2 = 0.889).
Conclusion: An assessment of trends in the reduction in hospital and postoperative mortality with an increase in number of laparoscopic operations will be determined only with standardized approaches to the usage of minimally invasive technologies in all areas of the Russian Federation.
Effectiveness and safety of olokizumab and levilimab in patients with COVID-19 in 2022: a cohort study
Authors: Petrov Vladimir I. , Ryazanova Anastasia Yu. , Tokareva Natalya S.
Published: October 2024

A single-center observational cohort study of the use of levilimab and olokizumab in patients with COVID-19 was conducted.
Purpose was to evaluate the effectiveness and safety of olokizumab and levilimab in the infectious diseases hospital of the Volgograd region in 2022.
Materials and methods: We analyzed 182 medical records of patients who were prescribed genetically engineered biological drugs in 2022. Long-term results of the use of drugs and disease outcomes after discharge or transfer to another medical fascility were assessed using the federal register of people with COVID-19.
Results: There were no significant differences in the effectiveness of levilimab and olokizumab. The chance of detecting signs of bacterial infection/sepsis was significantly higher by 2.7 times in patients receiving levilimab compared with olokizumab (OR=2.7, 95 % CI 1.43-5.17).
Features of diagnosis and treatment of chronic endometritis of bacterial-viral etiology
Authors: Tkachenko Lyudmila V. , Sviridova Natalia I. , Deleske Inna A.
Published: October 2024

The study revealed the combined effect of conditionally pathogenic flora and viral agents on the endometrium. Combined inflammatory and proliferative processes lead to severe changes in the endometrium and increase the risk of recurrent bleeding, pregnancy loss and infertility.
Current trends in the prevention of molar-incisal hypomineralisation
Authors: Sorokina Anastasia A. , Gavrilova Olga A. , Kornilova Veronika V.
Published: October 2024

Molar-incisal hypomineralization (MIH), or systemic enamel hypoplasia, as it can be found in the ICD-10 revision rubricator used in the Russian Federation, is increasingly being detected at a dental appointment. Every day, clinicians are faced with the problem of competent management of such patients, choosing effective methods of prevention and therapy. The review presents modern points of view on the etiology of the disease, the rationale for the use of treatment and preventive measures regarding this nosology, which contribute to improving the quality of dental care. Particular attention is paid to drugs produced by domestic manufacturers.
Criteria for identifying a risk group for iron deficiency anemia from among healthy women of reproductive age
Authors: Leshcheva Maria Yu. , Korichkina Lyubov N. , Korotkikh Irina N. , Poselyugina Olga B.
Published: October 2024

The article presents the results of a survey of healthy women of reproductive age with the definition of criteria for identifying a risk group for anemia from among them. The criteria were the indicators of peripheral blood: a decrease in the concentration of Hb (below 120.0 g/l) of blood and hematocrit, an expansion of RDW, a decrease in the volume of red blood cells (MCV), as well as a decrease in the amount of serum iron, ferritin, total protein that do not reach the lower limit of normal and the presence of a history of diagnosis of somatoform dysfunction of the autonomic nervous system. The application of the identified criteria for the early diagnosis of iron deficiency will allow effective timely preventive measures to prevent the development of iron deficiency anemia in women of reproductive age.
Assessment of the effect of solid herbal extract of primula veris l on the physical performance of rats after chronic alcohol intoxication
Authors: Perfilova Valentina N. , Muziko Elena A. , Borodkina Lyudmila E. , Tivon Yakov V. , Kataev Valery A. , Latypova Guzel M. , Kustova Margarita V. , Tyurenkov Ivan N.
Published: October 2024

The aim of this study was to evaluate the effect of solid herbal extract of Primula Veris L. and comparison drugs phenotropil and mildronate on the physical performance of female rats after chronic alcohol intoxication (CAI). CAI was modeled by replacing drinking water for 6 months with a 10 % solution of ethyl alcohol with sucrose (50 g/l). At the age of 16 months, the “Rotarod performance test”, “The horizontal rope walking test” and “Forced swim test with weight load” were performed. After CAI, rats show a deterioration in coordination and motor activity, a decrease in muscle strength and aerobic-anaerobic endurance. Solid herbal extract of Primula Veris L., phenotropil and mildronate contributed to an increase in the physical performance of animals after CAI.
The effect of exogenous melatonin on the dynamics of body weight and the level of Klotho protein in the blood of female rats subjected to prolonged dark deprivation
Authors: Kondakova Larisa I. , Bugaeva Lyubov I. , Bagmetova Victoria V. , Sirotenko Viktor S. , Smirnova Tatyana S.
Published: October 2024

The study of the effect of exogenous melatonin (0.3 mg/kg, intragastrically in 2% starch mucus, 14-day course) on the dynamics of body weight and the level of Klotho protein in the blood of 4-month-old white mongrel female rats subjected to 30-day dark deprivation (light-dark mode 24/0 h, artificial lighting 300 Lux). It has been shown that prolonged dark deprivation leads to a decrease in the level of Klotho protein, which is a marker of premature aging; a decrease in melatonin levels, fluctuations in the rate of body weight gain in sexually mature female rats. Exogenous melatonin contributed to an increase in the level of Klotho protein and the restoration of melatonin levels in the blood serum of animals, as well as a decrease in body weight, which indicates its protective effect on the condition of animals with accelerated aging caused by dark deprivation.
Treating chronic HCV infection in children: challenges and regional perspectives
Authors: Kaplunov Kirill O. , Shishimorov Ivan N.
Published: October 2024

The article discusses the treatment of chronic form of viral hepatitis C (HVGS) in children. Many problems of the issue under consideration relate to both the scarcity of official statistics and the ambiguity of approaches to the treatment of HVGS in children in our country and abroad. The authors show the most problematic loci from various aspects: from the side of epidemiology and clinical points of view - infectology, clinical pharmacology, and also proposed rational ways to solve existing problems.
Experience of using the passive exoskeleton EXAR-34 in complex rehabilitation of a patient with post-traumatic plexopathy due to gunshot cervicothoracic wound (clinical observation)
Authors: Vorobyov Alexander A. , Mazunov Anton S. , Gaivoronsky Alexey I. , Andryushchenko Fyodor A.
Published: October 2024

The use of passive exoskeletons is a promising direction in the treatment of patients with severe combat injuries to the shoulder girdle, leading to disability in 30 % of cases.
Aim: To demonstrate the capabilities of the passive exoskeleton EXAR-34 in the rehabilitation and habilitation of a victim with damage to the branches of the brachial nerve plexus.
Materials and methods: An analysis of medical documentation, physical examination, morphometry, and goniometry were carried out.
Clinical observation and discussion: A patient with post-traumatic left-sided plexopathy due to a gunshot perforating shrapnel cervicothoracic wound with gunshot fractures of the transverse processes of C6, C7, Th3 vertebrae, I–III ribs on the left after reconstructive intervention on elements of the brachial nerve plexus, when previously carried out rehabilitation measures were ineffective, during the first fitting of the EXAR-34 device, the range of active movements in the joints of the injured limb increased to 37,1–60,7 %, and routine motor skills were restored.
Conclusion:The experience of using the EXAR-34 device demonstrates high promise in complex rehabilitation and habilitation of patients after reconstructive interventions on the brachial plexus for combat wounds.
Non-compact cardiomyopathy. A case from practic
Authors: Bestolchenkov Andrey V. , Toporkova Nina G.
Published: October 2024

A retrospective analysis of the statistical data of persons who died in the Tambov region over the past 5 years revealed one case of death from non-compact cardiomyopathy. The incidence of non-compact cardiomyopathy in the population is 0.014 to 1.3 %. Due to the non-proliferation of this pathology, a single recorded case attracted attention for research. This study presents a 10-year-old patient who was admitted to the intensive care unit in the decompensation stage, during which the disease ended in death. After analyzing the medical documentation, it was found that with the development of the disease, the clinical picture was erased, symptoms from the cardiovascular system did not appear, signs of decompensation were not observed until the moment of this hospitalization. Death occurred suddenly, autopsy revealed non-compact cardiomyopathy of the left ventricle, which through its complications led to non-coronary ischemia of the subepicardial myocardium of the left ventricle, which was the cause of death. Since the pathology is quite rare, the purpose of our study is to consider, on the example of a clinical case, the factors contributing to the fatal outcome in non-compact cardiomyopathy.
Clinical study of the effectiveness of the use of metronidazole-based gels in the occurrence of inflammatory periodontal diseases without violations of periodontal attachment (literature review)
Authors: Popov Vyacheslav A. , Popova Daria A. , Sergeevna Malygina M. , Gorbatova Lyubov N. , Grzybovsky Andrey M. , Gorbatova Maria A. , Krylov Ilya A.
Published: October 2024

At this moment inflammatory diseases of the oral cavity are widespread in the world among people of different ages. Metronidazole is widely used as an effective drug for their treatment. This review is aimed at analyzing modern literature sources that tell about the role of metronidazole in the treatment of inflammatory disorder of oral cavity.
The versatility of using platelet-enriched autoplasm in medical practice
Authors: Mutova Tamara V. , Zatolokina Maria A. , Sukovatykh Boris S. , Mutov Viktor Ya. , Gunov Stanislav V. , Tverskoy Alexey V. , Kachmarskaya Lyudmila M. , Reshetnyakov Dmitry V.
Published: October 2024

The search for highly effective and safe methods in regenerative medicine has always been and remains an urgent problem. There are many drugs on the pharmacological market, but they cannot be considered to meet the requirements. One of the potential compounds capable of solving this problem is platelet-enriched autoplasm, which is economical and obtained directly from human blood with further centrifugation and platelet activation. An impressive number of studies are presented in the domestic and foreign literature, which confirm its effectiveness in assessing the area of a wound defect, the rate of regeneration and the absence of side effects. This is ensured by the content of a large number of growth factors and various biologically active compounds. In modern surgical practice, platelet-enriched autoplasm has found extensive use in the treatment of chronic wounds of various etiologies, prone to long-term course and frequent relapses; in cosmetology and aesthetic medicine in the issue of improving the appearance of scars; in urology in the treatment of erectile dysfunction; in obstetric and gynecological practice in improving pregnancy and pregnancy outcomes, reducing recurrence of adhesions, correcting functional sexual dysfunction and a favorable course of in vitro fertilization.
FAS system diagnostic and prognostic value in patients with chronic heart failure
Authors: Tokmachev Roman E. , Budnevsky Andrey V. , Kravchenko Andrey Ya. , Chernyshova Natalia I. , Chumachenko Arina V. , Fedortsov Alexander A.
Published: October 2024

The authors conducted the descriptive literature synthesis to present the structure and mechanism of the FAS family action, the purpose of determining the concentration of biomarkers in blood serum, the relationship of various FAS ligands levels with the patient’s clinical condition - the HF functional class (FC), as well as the sFASL using possibility to predict the HF course. The review analyzed 22 studies on the FAS system biomarkers participation in the HF pathogenesis and the relationship of their serum concentrations with the HF severity. A threshold sFASL value of 0.0999 ng/ml is associated with this pathology unfavorable course, while the increase in sFASL degree directly correlates with an increase in the FC of HF, the progression and death risks.
Experimental models of fibrosis
Authors: Kosolapov Vadim A. , Litvinov Roman A. , Spasov Alexander A.
Published: October 2024

Fibrosis, as a pathological process, is characterized by excessive accumulation of extracellular matrix and can affect various organs and tissues, including the lungs, liver, heart and kidneys, leading to serious morbidity and poor quality of life. The main mechanisms of fibrosis are disturbances in cellular signaling pathways, their regulation, interaction, including disturbances in the exchange of cellular regulatory signals, impaired mechanisms of cell adhesion, and changes in the extracellular matrix. All this makes the search for new agents with antifibrotic activity to be urgent. The review examines the basic mechanisms of the development of fibrosis with an emphasis on experimental models, as well as the potential and limitations of experimental models of fibrosis in the context of further search and study of new drugs with antifibrotic activity.
Monitoring of several morphometric parameters of the optic nerve and retina in persons without glaucoma and patients with primary open-angle glaucoma using various types of spectacle correction
Authors: Gndoyan Irina A. , Kuznetsova Natalia A. , Kushtareva Lilia B.
Published: October 2024

Purpose: to perform long-term monitoring of the state of several morphometric parameters of the retina and optic nerve in persons without glaucoma and patients with primary open-angle glaucoma (POAG) in the conditions of achieving tolerant and target IOP against the background of the use of various types of spectacle correction.
Material and methods: 139 patients aged 40–60 years with various types of clinical refraction were examined, 41 subjects (81 eyes) of them were without glaucoma, 98 patients (164 eyes) had POAG at stage I–II. In addition to standard methods, the scope of the examination included optical coherence tomography (OCT) of the optic nerve and the central area of the retina to determine the thickness of the retinal nerve fiber layer (RNFL), retinal ganglion cell complex (RGCC) and the area of the neuroretinal rim (NRR). The study was conducted in 4 observation groups. The first (21subjects) and the second (20 subjects) groups were represented by persons without glaucoma who used monofocal spectacle correction and progressive spectacle correction for near work, respectively. The third (50 subjects) and the fourth (48 subjects) groups were composed of patients with POAG who also used, respectively, monofocal spectacle correction for near vision or progressive spectacle correction against the background of topical hypotensive therapy with the achievement of tolerant and target IOP. The follow-up period was three years.
Results: There were no significant changes in the area of NRR (p 0,5) and in the thickness of RNFL (p 0,2) and RGCC (p 0,3) over the three-year follow-up period in all patients without glaucoma. In patients with POAG who applied progressive correction, no negative dynamics was revealed in the NRR area (p 0,5) and in the thickness of RNFL (p 0,5) and RGCC (p 0,5) during the follow-up period. POAG patients with using monofocal correction had noticeable losses in RNFL and RGCC thickness (p 0,05) without a significant decrease in the area of NRR (p 0,3).
Conclusion: The progressive spectacle correction using provides accommodative regulation of IOP in POAG and implements an indirect neuroprotective effect.
Regularities of variability in the anatomical structure of the left atrium in persons of different body types
Authors: Karakozova Elena A. , Chaplygina Elena V. , Aboyan Igor A. , Pakus Sergey M. , Karakozov Dmitry A. , Kornienko Natalia A.
Published: October 2024

Attention of cardiac surgeons and arrhythmologists are the ostia of the pulmonary veins, which are the place of the formation of trigger points during the development of atrial fibrillation. Data on the variability of the anatomical structure of the left atrium are scarce and are often contradictory, which makes it relevant to study the variability of the structure of the left atrium in the aspect of constitutional anatomy.
Purpose of the study: to establish patterns of variability in the structure of the left atrium, taking into account body type.
Materials and methods: The study is based on an analysis of the results of contrast-enhanced MSCT of the heart in 105 apparently healthy individuals.
Results: Analyzing the data obtained on the types of confluence of the pulmonary veins (PV) into the left atrium, it was found that in individuals of all body types, the flow of the 4-ostia pulmonary veins into the cavity of the left vertex occurs in the largest percentage of cases. Among the examined individuals, the following 7 variants of the anatomical structure of the left atrium with different frequencies of occurrence were identified: 1) typical confluence of the PV in combination with the oval shape of the orifice of the left appendage; 2) typical confluence of the PV in combination with the round shape of the mouth of the left atrium (LA) appendage; 3) confluence of the PV with a common collector on the left side in combination with the round shape of the mouth of the LA appendage; 4) confluence of the PV with a common collector on both sides in combination with the oval shape of the mouth of the LA appendage; 5) confluence of the PV with a common collector on both sides in combination with the round shape of the mouth of the LA appendage; 6) typical confluence of the PV in combination with the accessory pulmonary vein and the oval shape of the orifice of the LA appendage; 7) typical confluence of the PV in combination with the accessory pulmonary vein and the round shape of the auricle.
Development of modular extrusion bioprinter prototype
Authors: Kravchenko Sergey V. , Trofimenko Artyom I. , Sukhno Igor V. , Buzko Vladimir Yu. , Gneush Anna N.
Published: October 2024

Introduction: The aim of this work was to develop a prototype of a modular extrusion bioprinter capable of performing 2D and 3D printing with hydrogels based on sodium alginate and gelatin.
Materials and methods: The bioprinter uses Cartesian coordinate system, the print head is movable in Y and Z axes, the printing platform is in X axis and equipped with cooling system. Constructs were printed with 3 types of gels: based on gelatin with the addition various concentrations of xanthan gum; based on combination of gelatin and sodium alginate; based on gelatin and xanthan gum with the addition of carbon nanotubes.
Results: The constructs from various gels corresponded to the structure determined by their digital models.
Conclusions: The developed system allows performing 2D and 3D printing with gels based on gelatin, sodium alginate, including those containing carbon nanotubes and/or xanthan gum for a wide range of experimental tasks.
Vacuum-assisted laparostomy for peritonitis, abdominal sepsis and severe abdominal injury: methodology and practical aspects
Authors: Maskin Sergey S. , Derbentseva Tatyana V. , Alexandrov Vasily V. , Matyukhin Viktor V. , Biryulev Dmitry S. , Azad Rashid , Sigaev Sergey M.
Published: October 2024

One of the modern methods of multi-stage treatment of patients with widespread peritonitis, abdominal sepsis and abdominal injuries is vacuum-assisted laparostomy.
Aim: the methodology and practical aspects of the clinical use of vacuum-assisted laparostomy in the treatment of generalized peritonitis, abdominal sepsis and abdominal trauma are presented. A detailed illustrated description of the vacuum-assisted laparostomy technique is provided with the step-by-step implementation of all necessary procedures in patients with widespread peritonitis, abdominal sepsis and abdominal injuries. The attention of surgeons is drawn to important technical aspects of performing this technique to increase its safety and effectiveness.
Functional activity of thyroid gland follicular cells after exposure to tartrazine, bone trauma and administration of selenase
Authors: Morozov Vitaly N.
Published: October 2024

The food azo dye tartrazine requires further study to understand the safety of its effects and study the adaptation of the body against this background, in particular after bone injury, as well as ways to correct these changes. The purpose of the work was to determine the functional activity of follicular endocrinocytes on electronograms after long-term use of tartrazine and tibiae trauma with or without administration of selenase. The study involved 36 mature white rats (rats of the 1st group were injected with saline solution for 2 months, the 2nd group – a solution of tartrazine at a dose of 1500 mg/kg, the 3rd group – tartrazine and selenase at a dose of 40 mcg/kg), with subsequent tibiae trauma. On 3rd day, hypofunction of follicular cells was determined in rats of all groups, (17,20 ± 0,25), (12,90 ± 0,23), (13,80 ± 0,20) points, and by 24th day only in rats of 1st group recovery of their function was detected, (34,40 ± 0,22).
Formation of adaptive potential and level of physical condition in disabled people during the course of labor
Authors: Nagovitsyna Elena A. , Vasilyeva Natalia N.
Published: October 2024

А person with a disability that has begun to work is forced to pay the "physiological price of adaptation".
Materials and methods: The monitoring of the level of physical condition (LPC) by E.A. Pirogova and the adaptive potential (AP) by R.M. Baevsky was carried out on 130 disabled people during their work hours. Their working period lasted 2 weeks.
Results: An increase in LPC and a decrease in AP were revealed in people with childhood and psycho-neurological disabilities. In movement disabled people, the indicators of LPC decreased after the end of their work period.
Conclusions: Monitoring of indicators has determined a favorable impact of labor on people with childhood disabilities and low reserves of adaptive potential in movement disabled people. The determinative factors of LPC and AP in disabled people during the course of work have been established.
Prevention of postoperative contracture of the masticatory muscles using a multifunctional gnathic device when removing retinated teeth
Authors: Makedonova Yulia A. , Vorobyov Alexander A. , Alexandrov Alexander V. , Yarygina Elena N. , Puzikova Alla V. , Shishkin Vladislav D.
Published: October 2024

Full rehabilitation of patients after atypical extraction of wisdom teeth is not among the priority issues in dentistry, however, the duration and severity of postoperative inflammatory contracture of the masticatory muscles significantly affects the duration of the postoperative period, increasing the patient’s period of disability. Numerous studies indicate the advisability of local effects on tissues in order to improve blood and lymph circulation in the area of inflammation, which enhances the exchange of intercellular fluid and relaxes the masticatory muscles. A method of adaptive myogymnastics for early rehabilitation of patients is proposed and proved the effectiveness of its use.
Changes in the autoantibodies levels to neuroreceptors in the blood serum and brain tissue of rats during chronic administration of bromocriptine
Authors: Baturina Maria V. , Grudina Ekaterina V.
Published: October 2024

The experiments were carried out on 46 white laboratory male rats Wistar with a body weight of 250–280 g. Animals were daily administered intraperitoneally for 28 days with bromocriptine at a dose of 1 mg/kg and, as a control, physiological saline. In animals treated with bromocriptine, an accumulation of autoantibodies in blood serum and in brain tissue to neuroreceptors was found compared to control animals: NMDA (subunits NR1, NR2A, NR2B) and to dopamine receptors of the first and second types (DR1 and DR2). At the same time, the level of autoantibodies in the brain was significantly lower. High levels of autoantibodies were detected after 2 and 4 weeks from the start of immunization of animals. After completion of the chronic administration of bromocriptine, a high level of autoantibodies persisted 3 and 7 days after the last administration of the drug. 14 days after completion of the injections, the level of autoantibodies in the blood and brain decreased significantly. In the group of rats in which autoantibodies were determined 4 weeks after completion of injections, their level did not differ from the values in control animals. An increase of autoantibodies to the S100B protein was found. The levels of autoantibodies to the S100B protein in the blood serum had a positive moderate relationship with the content of autoantibodies to NR2A, NR2B and DR2 in the brain tissue. At the same time, there were no correlations with the levels of AAT to neuroreceptors in the blood.
El contexto sociopolítico de los reinados de Alfonso XII y Alfonso XIII. Una mirada especial a los derechos de la mujer
Authors: Sánchez-Cabezudo Tiffany
Published: October 2024

La investigación presente se enfoca en el análisis comparativo de los reinados de Alfonso XII y Alfonso XIII, periodos sucesivos que, pese a su continuidad cronológica, se distinguen marcadamente por sus características y consecuencias socioeconómicas y políticas. Durante el reinado de Alfonso XII, se observa una fase de relativa armonía en el panorama económico, social y político, resaltando la promulgación de la Constitución de 1876. Este documento legal estableció una forma de democracia apócrifa, ensombrecida por prácticas caciquiles diseñadas para perpetuar la alternancia en el poder de los partidos políticos tradicionales, configurando así un escenario de democracia limitada. Por su parte, el mandato de Alfonso XIII, se caracterizó por una marcada inestabilidad, evidenciada a través de significativos conflictos sociales y políticos. Contrario a lo que podría suponerse inicialmente, este periodo se destaca por importantes transformaciones en el rol y la posición de la mujer en la sociedad española. De esta manera, la presente investigación tiene como objetivo, aportar una visión crítica y profunda de un periodo de transición fundamental en la historia contemporánea de España, identificando el avance en los derechos y el estatus de la mujer en la sociedad española.