bluuebunny/crossref_metadata_2025 huggingface dataset:
The mobility of fluids through rocks
Authors: Lodhia Bhavik , Clark Stuart
Published: December 2021

Over the last decade, there has been an irreversible shift from hydrocarbon exploration towards carbon storage, low-carbon energy generation and hydrogen exploration. Whilst basin modelling techniques may be used to predict the migration of hydrocarbons through sedimentary basins on geological timescales, there remains little understanding of how fluids behave at the basin scale on present-day timescales. Maximum vertical fluid velocity, vmax, may be calculated as the product of mobility and buoyancy. We present am algorithm to determine the basin-scale mobilities of CO2 and methane with depth for sandstone and carbonate. CO2 and methane mobility and buoyancy increase by an order of magnitude at gas phase transitions and are significantly greater in sandstone than in carbonate. Critical properties of CO2 cause fluid mobility and buoyancy to be sensitive to changes in surface temperature. vmax for CO2 and methane are on scales of m/year. Our results indicate an optimal depth for CO2 storage of below 0.59 km and 1.24 km when surface temperature > 20oC and 0oC, respectively. vmax for hydrogen is approximately 2-10 times greater than other hydrocarbon fluids and this will have important consequences for the future use of basin modelling software for determining hydrogen migration for exploration and storage.
Comparison of Different Types of Therapy for Overactive Bladder: A Systematic Review and Network Meta-Analysis
Authors: Liu Peng , Sheng Lei , Li Yan , Shi Benkang , Guo Hongda , Zhang Qiujie , Guo Hu
Published: December 2021

To compare the efficacy and safety of different interventions (including Antimuscarinics, Mirabegron, OnabotulinumtoxinA, sacral neuromodulation (SNM) and peripheral tibial nerve stimulation (PTNS)) on idiopathic overactive bladder (OAB). PubMed, Embase, Cochrane library, and other sources were searched for randomized controlled trials (RCTs) comparing interventions of OAB from 1 January 2000 to 19 April 2021. A systematic review and network meta-analysis were performed by two authors independently. 55 RCTs involving 32,507 patients were included in this network. Overall, Antimuscarinics, Mirabegron, OnabotulinumtoxinA, SNM, and PTNS were more efficacious than placebo and SNM showed the best effect for reducing micturition frequency, urgency episodes and urgency urinary incontinence episodes. OnabotulinumtoxinA was the best in achieving reduction of 100% and ≥50% in the number of urinary incontinence episodes /day and PTNS was the best in reducing urinary incontinence episodes. The efficacy of Antimuscarinics, Mirabegron and PTNS were similar in reducing micturition frequency, urinary incontinence episodes and urgency urinary incontinence episodes. The results revealed that all interventions included in the network were efficacious in managing adult OAB syndrome compared with placebo. Furthermore, SNM and OnabotulinumtoxinA were the most efficient treatments for overactive bladder.
Arbuscular Mycorrhizal Fungi Regulate MAPK Pathway Genes Expression and Enhance Drought Tolerance of Populus Simonii × P. Nigra Seedlings
Authors: Tao Jing , Dong Fengxin , Wang Yihan , Chen Hui , Tang Ming
Published: December 2021

Background: Arbuscular mycorrhizal fungi (AMF) form a symbiotic relationship with host plants, which can promote plants to absorb more water and nutrients, and thus improve the stress resistance of plants. Our study aimed to investigate the effects of Rhizophagus irregularis on Populus simonii × P. nigra seedlings under drought stress. Results: The experiment was a completely random design with two water conditions (well-watered or drought stress) and two AMF treatments (inoculated with or without R. irregularis). Our results showed that mycorrhizal seedlings performed less oxidative damage and stronger tolerance of drought, which recorded higher photosynthesis and less concentrations of Malondialdehyde (MDA), H2O2, and proline under drought stress versus non-mycorrhizal seedlings. Under drought stress, AMF inoculation reduced soluble sugar concentration in leaves but promoted its accumulation in roots. The superoxide dismutase (SOD) activity in leaves and roots, and catalase (CAT) activity in roots of mycorrhizal seedlings were lower than non-mycorrhizal seedlings, but CAT activity in leaves of mycorrhizal seedlings was higher than non-mycorrhizal seedlings under drought stress. Drought stress and AMF inoculation both induced the expressions of MAPKs of P. simonii × P. nigra, but the expression patterns of MAPKs under four treatments were obviously different.Conclusions: Overall, our results demonstrated that mycorrhizal seedlings had less oxidative damage and stronger tolerance to drought. MAPKs expressions of P. simonii×P. nigra (PsnMAPKs) were induced by drought stress and AMF inoculation, and the expression patterns of PsnMAPKs in response to drought stress were different between mycorrhizal and non-mycorrhizal seedlings. Non-mycorrhizal seedlings may be adapted to drought by up-regulating MAPKs expressions leading to stomatal closure. Drought stress decreased serval PsnMAPKs expressions induced by AMF inoculation, which may be associated with mycorrhizal colonization.
Combined Elevation of Temperature and CO2 Levels Impacts the Production and Sugar Composition of Aphid Honeydew
Authors: Blanchard Solène , Verheggen François , de Vreken Isabelle Van , Richel Aurore , Detrain Claire
Published: December 2021

Honeydew is the keystone of many interactions between aphids and their predators, parasitoids, or mutualistic partners. Despite the crucial importance of honeydew in the aphid-ant mutualism, very few studies have investigated the potential impact of climate change on its production and composition. Here, we quantified changes in the sugar compounds and in the amount of honeydew droplets released by Aphis fabae reared on Vicia faba plants, under elevated levels of temperature and/or CO2. A combined elevation of these two abiotic factors increased honeydew production as well as the total amount in sugars, in particular the concentration of fructose and melezitose. Increased amount of sugars in phloem sap under elevated CO2 conditions, along with a raise of aphid metabolism and sap ingestion to compensate for water loss under elevated temperatures might explain these observed changes increase in honeydew production and sugar content. A higher amount of excreted honeydew coupled with a higher concentration in melezitose and fructose are expected to enhance both the feeding behavior and the laying of a recruitment trail by ant foragers, thereby reinforcing the ant-homopteran mutualism under a scenario of elevated temperature and CO2 levels. We discuss about the enhancing and counteracting effects of climate change on other biological agents (gut microorganisms, predators, parasitoids) that interact with aphids in a complex multitrophic system.
Acute Stress Induces Cerumen Secretion: Case series of Four Medical Students during Exams
Authors: Mohamed Rahma Sameh , Afify Mohamed , Kamal Manar Ahmed
Published: December 2021

Background and Objectives: Cerumen is a common physiological condition; it only becomes a problem if it causes a hearing impairment or other ear-related symptoms. There is increasing evidence for a relationship between stress and hearing problems. The study aims to understand the association between acute stress and increasing cerumen secretion among medical students during exams. Materials and Methods: The study is a retrospective, single-center, and consecutive case series conducted in Benha University Hospitals in Egypt We defined four cases of medical students who complained of earwax accumulation during their final exams from the 15th to the 13th of July 2021. Results: Four medical students participated in the study. Younger Females and males’ percentages were equal, and the mean age was 19.625 years old. Headache, ear discomfort, and ear pruritus are most common, followed by tinnitus, ear debris, and otitis media with effusion, while hearing loss, fever, and ear pain are slightly rare. The bilateral accumulation of earwax is typical than unilateral accumulation. Remowax was used in almost of cases and then ear wash. Males had high perceived stress, while females had moderate stress. Conclusions: This retrospective case series showed an association between acute stress and excessive cerumen secretion among small medical students during their final exams.
Social Networks and Internet Emotional Relationships on Mental Health and Quality of Life in Students: Structural Equation Modelling
Authors: Aliverdi Fatemeh , mahmoodi zohreh , Tourzani Zahra Mehdizadeh , Salehi Leili , Qorbani Mostafa , Mohamadi Farima
Published: December 2021

Background: Social networks and relationships create a sense of belonging and social identity and therefore have a major effect on mental health and quality of life, especially in young people. The present study was conducted to determine the predictor role of social networks and Internet emotional relationships on mental health and quality of life in students. Methods: The present cross-sectional study was conducted in 2021 on 350 students at Alborz University of Medical Sciences selected by convenience sampling. Data were collected using five questionnaires: Socioeconomic Status, Social Networks, Internet Emotional Relationships Mental Health, Quality of Life and a checklist of demographic details. Data were analyzed in SPSS-25, PLS-3, and Lisrel-8.8.Results: According to the path analysis results, mental health had the most significant positive causal relationship with Internet emotional relationships in the direct path (B=0.22) and the most negative relationship with socioeconomic status (B=-0.09). Mental health was assessed using DASS-21, in which higher scores mean higher mental disorders. Quality of life had the highest negative causal relationship with the DASS-21 score in the direct path (B=-0.26) and the highest positive relationship with socioeconomic status in the indirect path (B=0.023). The mean duration of using social networks (B=-0.067) and Internet emotional relationships (B=-0.089) had the highest negative relationship with quality of life.Conclusion: The use of the Internet and virtual networks, Internet emotional relationships and unfavourable socioeconomic status were associated with mental disorders and reduced quality of life in the students. Since students are the future of any country, it is necessary for policymakers to further address this group and their concerns.
Evaluation of Extracellular Volume by Computed Tomography is Useful for Prediction of Prognosis in Dilated Cardiomyopathy
Authors: Yashima Satomi , Takaoka Hiroyuki , Takahashi Manami , Kinoshita Makiko , Sasaki Haruka , Suzuki-Eguchi Noriko , Ota Joji , Nishikawa Yusei , Goto Hiroki , Kobayashi Yoshio
Published: December 2021

Purpose:

Dilated cardiomyopathy (DCM) is commonly encountered in daily clinical practice, and screening for coronary artery disease and other cardiomyopathies is necessary for its diagnosis. Cardiac CT is useful for the screening of coronary artery stenosis, and extracellular volume fraction (ECV) analysis by CT has become available using new specific software. Here, we evaluated the utility of ECV analysis using cardiac CT to predict patient prognosis in cases with DCM.
Methods:

We analyzed 70 cases with DCM and coronary computed tomography (CT) with available late-phase images. We evaluated the ECV of the left ventricular myocardium (LVM) using commercially available software (Ziostation 2, Ziosoft Inc, Japan).
Results:

ECV on LVM was 34.5±4.9%. Major adverse cardiac events (MACE) occurred in 20 cases (29%). ECV of the LVM on CT and the presence of significant valvular disease were significantly higher in cases with MACE than in those without (37.6±5.9 vs 33.2±3.9% and 55% vs 24%, P=0.0057 and P=0.013). LVEF was significantly lower in cases with MACE than in those without (22.3±7.6 vs 30.8±11.8%, P=0.0008). The best cut-off value of ECV on LVM for prediction of MACE was 32.7% based on receiver operating characteristics analysis. Cases with ECV ≥32.7% had significantly higher MACE based on Kaplan-Meier analysis (P=0.012). Only ECV on LVM was an independent predictor of MACE based on a Cox proportional hazards model (P=0.028).
Conclusion:

Evaluation of ECV on LVM by CT is useful for predicting MACE in patients with DCM.
A Pan-Cancer Analysis of the Tumorigenic Role of Yin-Yang1 (YY1) in Human Tumors
Authors: Pan Ke-Hao , Shi Nai-Peng , Liu Yi-Fan , Wang Ya-Li , Chen Ming
Published: December 2021

Background: Yin-yang1 (YY1) is a nuclear transcription factor possessing dual transcriptional activity, which has different expression in a variety of tumor tissues. However, it remains unclear that the role of YY1 in most tumors and its association with immune cell infiltration.Methods: The expression of YY1 was analyzed in pan-cancer data which were downloaded from The Cancer Genome Atlas (TCGA) database. The clinical survival data downloading from TCGA was used to analyze the effect of YY1 on clinical prognosis. We had access to the R package “clusterProfiler” to make the enrichment analysis of YY1. The score of the immune cell infiltration of TCGA samples was downloaded from published articles and the correlation between YY1 expression and the immune cell infiltration was analyzed.Results: YY1 had a high expression in 25 tumors and strongly associated with clinical stage. In most tumor types, the over-expression of YY1 was connected to the worse prognostic indicator, such as overall survival(OS), progression-free survival (PFS), disease-specific survival(DSS) and disease-free survival (DFS). Moreover, the expression of YY1 had a correlation with tumor mutation burden(TMB). Nearly all of immune-related genes had co-expression with YY1 and almost all genes had positive correlation with YY1 in all types of tumors. It's worth noting that the expression levels of B cells and T cells were lower in the group with high YY1 expression. In addition, 22 m6A methylation-related cells were co-expressed with YY1, such as METTL3, YTHDC1, FTO and so on. Conclusions: Our study leads to a suggestion that YY1 may be a marker of bad prognosis and high expression of YY1 may lead to immune infiltration and be connected to m6A methylation.
Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Damascus, Syria.
Authors: Alzabibi Mhd Amin , Shibani Mosa , Alsuliman Tamim , Ismail Hlma , alasaad Suja , Torbey André , Altorkmani Abdallah , Sawaf Bisher , Ayoub Rita , khalayli Naram , Kudsi Mayssoun
Published: December 2021

Background

Fibromyalgia is a chronic disease with a high burden. We aim to be the first to investigate the prevalence of fibromyalgia (FM) in Syria and assess its risk factors.
Methods

a self-reported questionnaire was distributed to the public to identify fibromyalgia patients using the American College of Rheumatology (ACR) 2010 modified criteria. Identified cases were matched using age with controls free from rheumatic disorders that were randomly sampled from the same population.
Results

out of 2966 participants, 350 (11.8%) satisfied the diagnostic criteria. Of these, only 29 (8.2%) were previously diagnosed by a physician, 239 (68.3%) were females, and 69 (19.71%) were diagnosed with depression. Female sex (OR=1.7, CI: 1.3-2.1), unemployment (OR=1.4, CI:1.1 – 1.79), diagnosis of major depressive disorder (OR=3.8, CI: 2.7 – 5.35), generalized anxiety disorder (OR=2.7, CI: 1.95 – 3.72), and irritable bowel syndrome (OR=2.4, CI: 1.78 – 3.17) were significant risk factors for FM.
Conclusion

our study revealed one of the highest prevalence rates of fibromyalgia ever reported in the general population. Efforts must be intensified to increase the awareness about this disease in the Syrian society as well as among healthcare providers.
Hands and feet radiologic involvements in systemic sclerosis
Authors: Badiee Fatemeh , Fatemi Alireza , Zahedpasha Reza , Gharib Hadi , Jokar Mohammadhassan , Livani Somayeh , Aghaie Mehrdad , Abdolahi Nafiseh
Published: December 2021

Aim
Systemic sclerosis (SSc) is a rare autoimmune disorder characterized by vascular and fibrosing involvement of the skin and internal organs. In this study we determined the prevalence and characteristics of radiological hands and feet involvements in Iranian SSc patients identified disease–phenotype associations.
Methods
43 SSc patients (41 women and 2 men), with a median age of 44.79 years (ranges 26 to 70 years) and a mean disease duration of 11.78 years (ranges 2 to 28 years) were studied in this cross-sectional study.
Results
42 patients had radiological changes both in hands and feet. Only one patient had changes just in hand. The most frequent changes that we found in hand was Juxta-articular Osteoporosis (93%), Acro-osteolysis (58.2%), Joint Space Narrowing (55.8%). The prevalence of joint space narrowing or acro-osteolysis were higher in subjects with active skin involvement (modified Rodnan skin score (mRSS)>14) (16/21 v 4/16 for patients with inactive skin involvement (mRSS<14); p = 0.002). The most frequent changes that we found in foot were Juxta-articular Osteoporosis (93%), Acro-osteolysis (46.5%), Joint Space Narrowing (58.1%), subluxation (44.2%). The presence of anti-ccp antibody was detected in 4 (9.3%), while positive rheumatoid factor was found in 13 (30.2%) of SSc patients.
Conclusion
This study corroborates that an arthropathy is common in SSc patients. The introduction of the specific radiological involvements of SSc needs to be confirmed by further studies. in order to define the appropriate prognosis and treatment of patients.
Short- and long-range interactions in the HIV-1 5’UTR regulate genome dimerization and packaging
Authors: Smyth Redmond , Ye Liqing , Gribling Anne-Sophie , Bohn Patrick , Kibe Anuja , Börtlein Charlene , Ambi Uddhav , Ahmad Shazeb , Olguin-Nava Marco , Smith Maureen , Caliskan Neva , von Kleist Max
Published: December 2021

Genome dimerization is a conserved feature of retroviral replication and a critical step in the HIV-1 life cycle, but how it is regulated is incompletely understood. Here, we developed FARS-seq (Functional Analysis of RNA Structure) to comprehensively identify sequences and structures within the HIV-1 5’UTR influencing dimerization. We found nucleotides important for dimerization throughout the HIV-1 5’UTR and identified distinct structural conformations in monomeric and dimeric RNA. The dimer displayed TAR, PolyA, PBS, and SL1-SL3 as stem-loops. In the monomer, SL1 was dramatically reconfigured into long- and short-range base-pairings with polyA and PBS, respectively. The polyA-SL1 interaction disrupts the major packaging motifs, and the PBS-SL1 interaction functionally couples the primer binding site with dimerization and Pr55Gag binding. Altogether, our data provide insights into late stages of HIV-1 life cycle and a mechanistic explanation for the link between RNA dimerization and packaging.
A genome-wide association study to identify candidate genes for metabolic disorders in offspring by in vitro fertilization
Authors: Liu Lihong , Ha Siyao , Li MingQing , Li Zhiling
Published: December 2021

Background: In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. Methods: We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. Results: We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. Conclusions: The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.
Pratylenchus smoliki, a new nematode species (Pratylenchidae: Tylenchomorpha) from the Great Plains region of North America
Authors: Powers Thomas , Todd Timothy , Harris Tim , Higgins Rebecca , MacGuidwin Ann , Mullin Peter , Ozbayrak Mehmet , Powers Kirsten , Sakai Kanan
Published: December 2021

Pratylenchus smoliki is a new species of root-lesion nematode described from corn-soybean production fields in the Central Great Plains of North America. It is characterized by populations with relatively abundant males, two lip annuli, females with a round functional spermatheca and a conoid to subcylindrical tail with a non-crenate, smooth terminus. In host preference tests, corn and wheat produce the largest nematode populations, whereas sorghum and soybeans produce less than 20% the numbers observed on corn. Scanning electron microscopy reveals that the en face patterns compare to those seen in Pratylenchus pseudocoffeae, P. scribneri, P. hexincisus, and P. alleni. The pattern is described as rectangular to trapezoidal subdorsal and subventral lips adjoining oral disc, but with a clear demarcation between the oral disc and the subdorsal and subventral sectors. A Maximum Likelihood COI tree recognizes P. smoliki as a moderately-well-supported clade with several haplotype subgroups. A Maximum Likelihood partial 28S tree provides strong support for the P. smoliki clade and reinforces the close relationships between species with similar en face patterns. Topotype specimens of P. alleni were demonstrably different from P. smoliki using DNA markers. The geographic range of P. smoliki overlaps with the ranges of P. alleni, P. scribneri, P. neglectus, P. hexicisus, and P. dakotaensis. The observed host range (corn, rye, sunflower, and wheat) suggests that P. smoliki may be native to the tallgrass prairie region of the Great Plains.
A POLÍTICA PÚBLICA DE APOIO FINANCEIRO A ESCOLA FAMÍLIA AGRÍCOLA DE NATALÂNDIA: UM ENFOQUE SOBRE A IMPLEMENTAÇÃO
Authors: Andrade Alex Pires , Palotti Pedro Lucas de Moura
Published: December 2021

O presente artigo procurou compreender, a partir da teoria bottom-up e dos escritos atuais sobre os burocratas de nível de rua, o processo de implementação da política estadual de apoio financeiro às Escolas Famílias Agrícolas em Minas Gerais. Para tanto, foram realizados três grupos focais com professores, famílias e estudantes dessas escolas no município de Natalândia/MG. Os resultados apontam que a implementação foi bem-sucedida em razão da implementação conjunta, o que garantiu aos implementadores da Pedagogia da Alternância a capacidade de se dialogar em prol da essência do programa.
GESTÃO POR RESULTADOS E A NOVA ROTINA ESCOLAR NA REDE MUNICIPAL DE ENSINO DE PORTO ALEGRE (RME/POA)
Authors: Leal Caroline Pereira
Published: December 2021

O presente artigo discute a recente reforma na política em educação do município de Porto Alegre. Nosso objetivo é apresentar a nova rotina escolar implantada nas escolas da Rede Municipal de Ensino de Porto Alegre (RME/POA), a partir de 2017, buscando descrever o processo reformista e discutir os instrumentos adotados pela administração municipal como forma de construção e de funcionamento da gestão por resultados aplicadas à educação. Por meio de pesquisa documental foram consultados documentos oficiais e notícias jornalísticas a respeito da nova rotina escolar que, através de uma análise descritiva comparada, de abordagem qualitativa dos dados, nos permitiu verificar que a intervenção efetuada na realidade escolar gerou intensificação do trabalho docente e não se traduziu em efetividade e criação de valor público.
Detecting, extracting and classifying foreign objects in inter-basin channels to ensure water supply safety
Authors: Chen Junjie , Liu Donghai
Published: December 2021

Foreign objects (e.g., livestock, rafting, and vehicles) intruded into inter-basin channels pose threats to water quality and water supply safety. Timely detection of the foreign objects and acquiring relevant information (e.g., quantities, geometry, and types) is a premise to enforce proactive measures to control potential loss. Large-scale water channels usually span a long distance and hence are difficult to be efficiently covered by manual inspection. Applying unmanned aerial vehicles for inspection can provide time-sensitive aerial images, from which intrusion incidents can be visually pinpointed. To automate the processing of such aerial images, this paper aims to propose a method based on computer vision to detect, extract, and classify foreign objects in water channels. The proposed approach includes four steps, i.e., aerial image preprocessing, abnormal region detection, instance extraction, and foreign object classification. Experiments demonstrate the efficacy of the approach, which can recognize three typical foreign objects (i.e., livestock, rafting, and vehicle) with a robust performance. The proposed approach can raise early awareness of intrusion incidents in water channels for water quality assurance.
Determinants of household water demand: a cross-sectional study in South West Nigeria
Authors: Oyerinde A. O. , Jacobs H. E.
Published: December 2021

Estimating residential water demand in developing countries is complicated by the unique nature of water supply, characterised by unequal access and multiple water sources. Using cross-sectional data obtained from a survey of 1,300 households, the determinants of residential water demand were predicted using a multiple linear regression model. The determinants include access to water, household size, trip number, monthly income, payment for water, educational qualification, trip time and house type. The determinants predicted daily water consumption with an F(9, 1,014) = 81.063, P < 0.05, R2 = 0.450. Daily water consumption was found to be 2.8 times more per household and 4.4 times more per capita for those with on-site access, compared to those with off-site access. Moreover, consumption was influenced by the various water source categories.
Research on application of ecohydrology to disaster prevention and mitigation in China: a review
Authors: Fan Guangli , Xia Jun , Song Jinxi , Sun Haotian , Liang Dong
Published: December 2021

In this paper, the ecohydrology measures including water management and interaction of ecological hydrology were considered to take a holistic view on the impact of climate, ecology, environment, and topography on different types of disasters. In the first step, the contents of the grim disaster situation and the information framework of ecohydrology with disasters were evaluated. Nest, the creation of ecohydrology and its work with related disasters were summarized. Three disasters including flood, drought, and geohazard were evaluated and three examples (Dujiangyan Irrigation Project, Karez, and Ecological slope) have been separately discussed for considering the concept of the problem. Depending on the characteristics and potential for an effect in different disasters, there needed to be some challenges and opportunities for ecohydrology facing related disasters in various fields, such as National Space Planning, Sponge City and the ‘One Belt And One Road’ Initiative. Finally, some valuable conclusions were drawn on the application of ecohydrology to disaster prevention and mitigation. Furthermore, the key systemic settings between water management, hydrology, and ecology were described, which is of the main importance for social disaster reduction, emergency management, and protection of accident prevention.
Experimental studies of iron transformations kinetics and autocatalysis during its physicochemical removal from underground water
Authors: Martynov S. Yu , Poliakov V. L.
Published: December 2021

The mathematical model of physicochemical iron removal from groundwater was developed. It consists of three interrelated compartments. The results of the experimental research provide information in support of the first two compartments of the mathematical model. The dependencies for the concentrations of the adsorbed ferrous iron and deposited hydroxide concentrations are obtained as a result of the exact solution of the system of the mass transfer equations for two forms of iron in relation to the inlet surface of the bed. An analysis of the experimental data of the dynamics of the deposit accumulation in a small bed sample was made, using a special application that allowed selection of the values of the kinetic coefficients and other model parameters based on these dependencies. We evaluated the autocatalytic effect on the dynamics of iron ferrous and ferric forms. The verification of the mathematical model was carried out involving the experimental data obtained under laboratory and industrial conditions.
Treatment of the Allura Red food colorant contaminated water by a novel cyanobacterium Desertifilum tharense
Authors: Gül Ülküye Dudu , Şenol Zeynep Mine , Ertit Taştan Burcu
Published: December 2021

The biosorption properties of a newly isolated and identified cyanobacterium called Desertifilum tharense were investigated in the current study. Following morphological and molecular identification (16S rRNA sequencing analysis), the food colorant removal potential of this new isolate was determined. Moreover, the isotherm, kinetic, and thermodynamic studies were performed, and also the biosorbent characterization was studied after and before colorant biosorption with Fourier transform infrared and scanning electron microscopy analysis. Additionally, the changes in chlorophyll content of the biosorbent were examined after and before colorant treatment. The newly isolated cyanobacterial biosorbent removed 97% of Allura Red food colorant/dye at 1,500 mg L−1 initial dye concentration successfully at optimal conditions. Langmuir isotherm and pseudo-second-order kinetic models were fitted with the biosorption of the dye. The D-R model showed that the biosorption process occurred physically. The chlorophyll-a content of the biosorbent was negatively affected by the biosorption. The newly isolated and identified cyanobacterium seems to be a successful candidate for use to treat highly dye concentrated wastewaters.
Symbolism of God’s Protection over the Chosen People during the Journey to the Promised Land in Origen’s Homilies to Psalm 77 (78)
Authors: Bardski Krzysztof
Published: December 2021

The article analyzes selected literary motifs of Psalm 77, which were used by Origen to formulate more-than-literal interpretations. The methodology of research on the processes of creating allegorical and symbolic associations has been applied to the following literary motifs: the separation of the waters of the Red Sea, the cloud and the pillar of fire leading the Israelites through the wilderness, water from a rock, and manna from heaven.
Juego del ajedrez y la toma de decisiones en los docentes de educación básica (Escuela Juan Pablo Segundo, Región de Los Lagos-Chile)
Authors: Martínez Marlenis , Solis Doris , Valdes Guillermo
Published: December 2021

El presente artículo tiene como objetivo determinar la incidencia del juego del ajedrez en la aplicación de la toma de decisiones de los docentes de la Escuela Juan Pablo Segundo, región de los Lagos-Chile. Se utilizó el enfoque cuantitativo con un tipo de investigación descriptiva y diseño no experimental. La población constituida por 65 docentes que laboran en la institución antes referida; se empleó la técnica de la encuesta y como instrumento un cuestionado de preguntas cerradas con dos alternativas de respuestas, el mismo fue validado a través del juicio de expertos y la confiablidad con la técnica de Kuder de Richardson. Los resultados demostraron que los docentes conocen el juego del ajedrez, pero les falta capacitación en la aplicación de la toma de decisiones. El estudio permitió establecer la importancia del ajedrez y su utilización en la toma decisiones, dado que fortalece los conocimientos y potencia el desarrollo de capacidades en el desarrollo físico mental en los docentes de educación básica.
Metabolic Syndrome, Alzheimer’s Disease, and Covid 19: A Possible Correlation
Authors: Finelli Carmine
Published: December 2021

:

Age and comorbidities are key indicators of hospital admission, serious illness, and mortality
in COVID-19 patients. Patients with age-related comorbidities, such as cardiovascular disease,
hypertension, diabetes, chronic kidney disease, NAFLD, obesity, and metabolic syndrome,
are more likely to require hospitalization and suffer severe sickness of COVID-19. Patients with
Alzheimer’s disease and risk factors associated with dementia may also be more vulnerable to serious
COVID-19 infection. Peripheral inflammation, including in patients who recover from illness,
may promote the course of neurodegenerative disorders through neuroinflammatory pathways.

:

The aim of this study is to examine the impact of COVID-19 on immunity in patients with age-related
diseases such as metabolic syndrome and Alzheimer’s disease and also to hypothesize the possible
correlation between metabolic syndrome, Alzheimer’s disease, and COVID-19. Identifying
the mechanisms that explain the complicated interaction between metabolic syndrome,
Alzheimer’s disease, COVID-19, inflammation, and immunity could be crucial to designing effective
pharmacological therapies and procedures. This study adds to our basic information about the
new coronavirus by synthesizing current knowledge of these linkages. To reduce inflammation and
enhance immunity, patients should acquire good lifestyle practices. Walking, breathing exercises,
and a nutritious diet all help in improving lung capacity and immunity.

:

Future research into novel therapeutics for patients with metabolic syndrome, Alzheimer’s disease,
and COVID-19 inflammation and immunology is encouraged by this paper.
The Effects of Stimulation with PMA/Ionomycin on CD4+ T Cell Proliferation and Surface CD4 Molecule Modulation of Patients with LRBA Deficiency and CVID with the Unsolved Genetic Defect
Authors: Salami Fereshte , Shariati Sahar , Rasouli Seyed Erfan , Delavari Samaneh , Tavakol Marzieh , Sadri Homa , Asghari Babak , Yazdani Reza , Rezaei Nima , Abolhassani Hassan , Azizi Gholamreza
Published: December 2021

Background:

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiencies. LPS-responsive beige-like anchor protein (LRBA) deficiency is a combined immunodeficiency characterized by a CVID-like phenotype. Affected patients by LRBA and CVID present a wide range of clinical manifestations, including hypogammaglobulinemia, recurrent infections, autoimmunity, as well as T cell abnormality.

Methods:

The study population comprised of patients with CVID (n=10), LRBA deficiency (n=11), and healthy controls (n=12). CD4+ T cell frequency and CD4 MFI (mean fluorescence intensity) were evaluated using flow cytometry before and after stimulation with PMA/ION.

Results:

The frequencies of CD4+ T cells were significantly lower in patients with LRBA deficiency than in HCs before and after treatment. In the unstimulated state, the CD4+ T cells frequency in CVID patients was significantly lower than in HCs. There were no statistically significant differences between patients and healthy individuals in CD4+ T cell proliferation. Compared to HCs, LRBA and CVID patients showed a lower CD4 MFI in unstimulated conditions. Furthermore, CD4 MFI decreased in both patients and the control group following activation.

Conclusion:

Despite the reported decrease in CD4+ T cell frequency in patients with CVID and LRBA deficiency, our findings demonstrated that their CD4+ T cells have a normal proliferative response to stimuli similar to healthy individuals
From Bench Side to Bed-Travelling on a Road to Get a Safe and
Effective Vaccine against COVID-19, Day to Save the Life
Authors: Ray Suman Kumar , Mukherjee Sukhes
Published: December 2021

:

Coronavirus Disease 2019 (COVID-19) is caused by a new strain of
coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-
2). It is the most challenging pandemic of this century. The growing
COVID-19 pandemic has triggered extraordinary efforts to restrict the virus in
numerous ways, owing to the emergence of SARS-CoV-2. Immunotherapy,
which includes artificially stimulating the immune system to generate an immunological
response, is regarded as an effective strategy for preventing and
treating several infectious illnesses and malignancies. Given the pandemic's high
fatality rate and quick expansion, an effective vaccination is urgently needed to
keep it under control. The basic goal of all COVID-19 vaccine programs is to develop
a vaccine that causes the generation of surface protein neutralizing antibodies
in subjects. The epitope discovery for the SARS-CoV-2 vaccine candidates
is likewise made using an immuno-informatics methodology. It can be
used to find the epitopes in viral proteins important for cytotoxic T cells and B
cells. A safe and effective COVID-19 vaccine that can elicit the necessary immune
response is necessary to end the epidemic. The global search for a safe and
effective COVID-19 vaccine is yielding results. More than a dozen vaccines
have already been approved around the world, with many more in the clinical
trials. Patents can cover the underlying technology used to generate a vaccine,
whereas trade secrets can cover manufacturing methods and procedures.
O antigo Paço dos arcebispos de Braga
Authors: Martins Manuela , Mar Ricardo , Ribeiro Maria do Carmo
Published: December 2021

O antigo Paço dos arcebispos de Braga ocupa um inequívoco lugar de destaque na paisagem urbana bracarense, cuja complexa história se entrecruza com a da construção do próprio palácio, constituído por um complexo de edifícios que se foram anexando uns aos outros, entre os séculos XIV e XVIII. Situado nas proximidades da Sé Catedral, o Paço arcebispal desenvolve-se por uma vasta área do centro histórico de Braga, sendo reconhecido como um dos edifícios patrimoniais mais emblemáticos da cidade, que tira também partido das características que foram conferidas aos seus espaços envolventes no contexto da intervenção de restauro ocorrida entre 1930 e 1950. Como exemplar complexo de arquitetura civil, o Paço arcebispal conta-nos uma história longa e dinâmica, associada aos protagonistas que ajudaram a dar forma aos edifícios que formalizam o palácio, um indiscutível testemunho do poder e importância que os arcebispos tiveram na história de Braga. O Paço dá também conta da evolução e do pulsar da cidade ao longo de séculos, pois nele encontramos expressões das diferentes tendências artísticas e culturais que se fizeram sentir, um pouco por toda a Europa, entre os finais da Idade Média e os finais do Antigo Regime. Assim, os seus sucessivos acrescentos e fases construtivas representam exemplos paradigmáticos da racionalidade urbanística e das linguagens arquitetónicas características do longo período de progressiva construção dos “paços” que compõem o Paço arcebispal bracarense. A história da sua evolução representa também um excelente testemunho das mudanças ocorridas nas cidades com vocação senhorial, permitindo-nos entender como foram mudando as estratégias de propaganda e de afirmação pública do poder no espaço urbano medieval, renascentista e barroco.
Patrones de distribución de la familia Solieriaceae (Gigartinales, Rhodophyta) en México
Authors: Hernández Oscar , Dreckmann Kurt M. , Núñez Resendiz María Luisa , Sentíes Abel
Published: December 2021

Antecedentes y Objetivos: Solieriaceae es una familia de algas rojas marinas muy diversa y distribuida ampliamente en zonas tropicales y templadas del mundo. En México, se encuentran 21 de las 94 especies conocidas, lo que representa 23% de la diversidad a nivel mundial. A pesar del conocimiento que se tienen sobre la diversidad y distribución de las especies de esta familia en México, aún se desconocen sus aspectos biogeográficos, fundamentales para el entendimiento del arreglo y evolución en el espacio geográfico de cualquier grupo taxonómico. El objetivo del presente estudio fue identificar y describir los patrones de distribución de las especies de Solieriaceae en México, mediante un Análisis Cladístico de Distribución y Endemismo (PAE-CADE), discutir los procesos que les han dado lugar; y a partir de ello, aportar evidencia que contribuya a futuras propuestas de conservación que involucren a estos organismos.Métodos: Mediante la definición de cuadrantes de 2° de latitud por 2° de longitud para los océanos Atlántico y Pacífico, se construyó una matriz de presencia/ausencia, a partir de la cual se realizó un análisis de PAE-CADE.Resultados clave: Se definieron dos grandes áreas de congruencia: el océano Pacífico con tres áreas anidadas, y el océano Atlántico con cuatro áreas anidadas; todas definidas por la presencia de una o más especies restringidas. Asimismo, se detectaron una zona de convergencia biótica en el océano Pacífico y un área de endemismo en la Sonda de Campeche.Conclusiones: Se reconoce que las costas mexicanas se componen por áreas de congruencia anidadas con una complejidad biótica; es decir, por áreas con diferente afinidad y origen biogeográfico. Sin embargo, la incorporación de información filogenética a este tipo de estudios permitirá integrarla dentro del esquema de la biogeografía evolutiva.
Modeling of the comprehensive assessment of the effectiveness of economic entities: Management aspect
Authors:   Department of Administrative Management and Foreign Economic Activity, National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine, et al. Zaburanna
Published: December 2021

The COVID-19 pandemic has caused an unprecedented structural change in the current evolutionary development of the national economy of Ukraine. Situational trends that arise in the open economy of the country require reactive changes in the conditions for doing business and force public authorities to update strategies or mechanisms to support it. At the same time, a number of explicit factors, including unemployment and inflation, further exacerbate the problems in business activities. This makes it necessary to search for relevant methods that would allow interested stakeholders to carry out uninterrupted diagnostics of the state of entrepreneurship development and, on this basis, determine effective government policy tools to support this sector of the economy. Important management measures are the current assessment of the business sector, determination of its future development, and forecasting the consequences of the impact of the external environment on the activities of enterprises. At the same time, the updated methods should take into account the evolution of the development of the national economy and the specifics of the modern activities of large, medium, and small enterprises in Ukraine. The purpose of the article is to develop a relevant methodology for assessing the current activities of business entities in the managerial aspect, as well as modeling the forecast for the development of this sector of the economy, taking into account the specifics of the functioning of the national economy of Ukraine. The use of the methodology proposed by the authors will make it possible to systematically assess the current state of entrepreneurship development and respond in advance to negative factors that cause its inert development.
Efecto de las estrategias de innovación en el éxito de las empresas
Authors: Alarcón Vásquez Felipe , Leal Paredes Santiago , Flores Pérez Jorge
Published: December 2021

La innovación es el núcleo de las estrategias de negocios actuales, las empresas son cada vez más globales y competitivas, obligando a las empresas a innovar en productos y servicios. Las estrategias de innovación forman parte de la empresa para llegar al éxito y lo que obliga a las organizaciones a innovar para no salir del mercado. El propósito de la presente investigación es analizar y realizar una reflexión sobre el efecto de las estrategias de innovación en el éxito de las empresas. El objetivo es conocer la tendencia y el impacto que tendrá cada estrategia de innovación. El estudio realizó una amplia revisión de literatura permitiendo analizar las estrategias de innovación con relación al éxito. Las conclusiones están vinculadas a cómo la investigación en innovación genera valor para impulsar el éxito, además de visualizar que tipo de estrategias de innovación utilizar en el área requerida y el tiempo adecuado.
Высокотемпературная сверхпроводниковая магнитная система для изучения нейронной активности
Authors: Диев Д.Н. , Ковалев И.А. , Макаренко М.Н. , Наумов А.В. , Поляков А.В. , Сурин М.И. , Шутова Д.И. , Щербаков В.И.
Published: December 2021

The paper describes a high-temperature superconducting magnetic system (HTS SMS) to equip an experimental stand intended for neuron activity researches under constant and low-frequency magnetic fields up to 1 T. The design of the magnetic system together with its electromagnetic and cryogenic parameters is briefly discussed. The test results of the preliminary experiments conducted in liquid nitrogen at 77 K for two interchangeable magnets are given. The first magnet was manufactured in the form of a double pancake coil wound with 4 mm high HTS tape. The second magnet was made of pure copper wire with no frame and was impregnated with a thermally conducting epoxy resin. The advantages of the HTS pancake coil were demonstrated in comparison with the cryo-resistive solenoid. Low energy consumption of the HTS magnetic system will allow conducting continuous non-invasive monitoring of biological objects in a magnetic field.
Мобильный ускоритель на базе безжелезного импульсного бетатрона для радиографирования динамических объектов
Authors: Куропаткин Ю.П. , Нижегородцев В.И. , Романов И.Н. , Савченко К.В. , Селемир В.Д. , Урлин Е.В. , Фомичёв В.А. , Чинин А.А. , Шамро О.А.
Published: December 2021

The paper concerns the mobile accelerator based on the ironless pulsed betaron. The accelerator is aimed to radiograph dynamic objects with a large optical thickness. It has a possibility to obtain up to three γ-pulses in one cycle of the acceleration. The accelerator operation description and results of its testing powering in a single-pulse mode are provided. The estimated boundary energy of an electron beam is equal to 60 MeV at the capacitance value of 1.8 mF of the storage of the betatron electromagnet pulsed power system. The thickness of the lead test object examined with γ-rays is 140 mm at 4 m from the tantalum target. The full width of the output γ-pulse at half maximum is equal to 120 ns. The dimension of the radiation source is 3×6 mm. The application of these accelerators within the radiographic complex will allow increasing the investigation efficiency due to the optimization of the hydrodynamic experiments geometry and the cost reduction.