bluuebunny/crossref_metadata_2025 huggingface dataset:
Symmetric Graphene Dielectric Nanowaveguides as Ultra-Compact Photonic Structures
Authors: Teng Da , Wang Yuncheng , Xu Tianzi , Wang Huayu , Shao Qinqin , Tang Yanan
Published: May 2021

A symmetric graphene plasmon waveguide (SGPWG) is proposed here to achieve excellent subwavelength waveguiding performance of mid-infrared waves. The modal properties of the fundamental graphene plasmon mode are investigated by use of the finite element method. Due to the naturally rounded tips, the plasmon mode in SGPWG could achieve a normalized mode field area of ~10−5 (or less) and a figure of merit over 400 by tuning the key geometric structure parameters and the chemical potential of graphene. In addition, results show that the modal performance of SGPWG seems to improve over its circular counterparts. Besides the modal properties, crosstalk analysis indicates that the proposed waveguide exhibits extremely low crosstalk, even at a separation distance of 64 nm. Due to these excellent characteristics, the proposed waveguide has promising applications in ultra-compact integrated photonic components and other intriguing nanoscale devices.
Electrochemical Characterization and Detection of Lead in Water Using SPCE Modified with BiONPs/PANI
Authors: Okpara Enyioma C. , Nde Samuel Che , Fayemi Omolola E. , Ebenso Eno E.
Published: May 2021

The need for constant assessment of river water qualities for both aquatic and other biological survival has emerged a top priority, due to increasing exposure to industrial pollutants. A disposable screen print carbon electrode was modified with a conductive polymer (PANI) and Zn and/or Cu oxides NPs, obtained through bioreduction in citrus peel extracts (lemon and orange), for ultra-sensitive detection of PB2+, in the Crocodile River water sample. The synthesized materials were characterized with Fourier-transform infra-red spectroscopy (FTIR), ultra-violet visible spectroscopy (UV-Vis), and scanning electron microscopy (SEM). The SPC-modified electrodes designated as SPCE/LPE/BiONPs/PANI and SPCE/OPE/BiONPs/PANI were characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) and eventually deployed in the electrochemical detection of PB2+ in water using square wave voltammetry (SWV) technique. The electrochemical responses of the modified electrodes for both CV and EIS in 0.1 M HCl demonstrated enhanced performance relative to the bare SPCE. A detection and quantification limit of 0.494 ppb and 1.647 were obtained at SPCE/LPE/BiONPs/PANI, respectively, while a detection and quantification limit of 2.79 ppb and 8.91 ppb, respectively, were derived from SPCE/OPE/BiONPs/PANI. The relative standard deviations (RSD) for SPC electrode at a 6.04 µM PB2+ analyte concentration was 4.76% and 0.98% at SPCE/LPE/BiONPs/PANI and SPCE/LPE/BiONPs/PANI, respectively. The effect of copper, zinc, iron, cobalt, nickel, and magnesium on the stripping peaks of PB2+ at SPCE/OPE/BiONPs/PANI, showed no significant change except for cobalt, with about 17.67% peak current drop. The sensors were assessed for possible determination of PB2+ in spiked river water samples. The average percentage recovery and RSD calculated were 94.25% and 3.74% (n = 3) at SPCE/LPE/BiONPs/PANI and, 96.70% and 3.71% (n = 3) at SPCE/OPE/BiONPs/PANI, respectively. Therefore, the fabricated sensor material could be used for environmental assessment of this highly toxic heavy metal in the aquatic system
Studies of Defect Structure in Epitaxial AlN/GaN Films Grown on (111) 3C-SiC
Authors: Serban Andreea , Ene Vladimir , Dinescu Doru , Zai Iulia , Djourelov Nikolay , Vasile Bogdan , Leca Victor
Published: May 2021

Several aspects such as the growth relation between the layers of the GaN/AlN/SiC heterostructure, the consistency of the interfaces, and elemental diffusion are achieved by High Resolution Transmission Electron Microscopy (HR-TEM). In addition, the dislocation densities together with the defect correlation lengths are investigated via High-Resolution X-ray Diffraction (HR-XRD) and the characteristic positron diffusion length is achieved by Doppler Broadening Spectroscopy (DBS). Moreover, a comparative analysis with our previous work (i.e., GaN/AlN/Si and GaN/AlN/Al2O3) has been carried out. Within the epitaxial GaN layer defined by the relationship F4¯3m (111) 3C-SiC || P63mc (0002) AlN || P63mc (0002) GaN, the total dislocation density has been assessed as being 1.47 × 1010 cm−2. Compared with previously investigated heterostructures (on Si and Al2O3 substrates), the obtained dislocation correlation lengths (Le = 171 nm and Ls =288 nm) and the mean distance between two dislocations (rd = 82 nm) are higher. This reveals an improved crystal quality of the GaN with SiC as a growth template. In addition, the DBS measurements upheld the aforementioned results with a higher effective positron diffusion length LeffGaN2 = 75 ± 20 nm for the GaN layer.
Structure–Activity Relationships between the State of Silver on Different Supports and Their I2 and CH3I Adsorption Properties
Authors: Azambre Bruno , Chebbi Mouheb , Ibrahim Nagham
Published: May 2021

In this study, the performances of silver-impregnated adsorbents prepared from different host supports (SBA-15, alumina, ceria, and faujasite Y zeolite) and calcined or not at 500 °C (1 h) were compared for the capture of I2 and CH3I. By keeping the silver content rather similar (about 15–17 wt %) among the sorbents, it was possible to assess the effect of silver dispersion and speciation on the adsorption capacities measured for both adsorbates. In a first part, several characterization techniques (XRD, DRS-UV-Vis, TEM, etc.) were used to probe the state of silver in the calcined and non-calcined materials. It was found that the characteristics of silver species are strongly influenced by the thermal treatment, the presence or absence of exchange sites, and the stability of the supports. Silver agglomeration was enhanced after calcination at 500 °C especially for supports bearing no exchange sites (SBA-15) or no ordered pores (alumina and ceria). Then, the adsorption performances of the studied silver sorbents were discussed in relation with their physicochemical characteristics. After-test characterizations were useful to assess the proportion of silver species that have reacted with CH3I and I2 to yield AgI precipitates. Depending on the adsorbate, different trends were obtained. I2 adsorption/reaction with silver sites was found to be quantitative (I/Ag ≈1), whatever the silver speciation and dispersion on the support. By contrast, a high proportion of cationic silver species was found essential to increase CH3I adsorption (I/Ag about 0.6–0.7 against 0.2–0.3 for Ag agglomerated species).
Hyperfine Interactions in the NV-13C Quantum Registers in Diamond Grown from the Azaadamantane Seed
Authors: Nizovtsev Alexander P. , Pushkarchuk Aliaksandr L. , Kilin Sergei Ya. , Kargin Nikolai I. , Gusev Alexander S. , Smirnova Marina O. , Jelezko Fedor
Published: May 2021

Nanostructured diamonds hosting optically active paramagnetic color centers (NV, SiV, GeV, etc.) and hyperfine-coupled with them quantum memory 13C nuclear spins situated in diamond lattice are currently of great interest to implement emerging quantum technologies (quantum information processing, quantum sensing and metrology). Current methods of creation such as electronic-nuclear spin systems are inherently probabilistic with respect to mutual location of color center electronic spin and 13C nuclear spins. A new bottom-up approach to fabricate such systems is to synthesize first chemically appropriate diamond-like organic molecules containing desired isotopic constituents in definite positions and then use them as a seed for diamond growth to produce macroscopic diamonds, subsequently creating vacancy-related color centers in them. In particular, diamonds incorporating coupled NV-13C spin systems (quantum registers) with specific mutual arrangements of NV and 13C can be obtained from anisotopic azaadamantane molecule. Here we predict the characteristics of hyperfine interactions (hfi) for the NV-13C systems in diamonds grown from various isotopically substituted azaadamantane molecules differing in 13C position in the seed, as well as the orientation of the NV center in the post-obtained diamond. We used the spatial and hfi data simulated earlier for the H-terminated cluster C510[NV]-H252. The data obtained can be used to identify (and correlate with the seed used) the specific NV-13C spin system by measuring, e.g., the hfi-induced splitting of the mS = ±1 sublevels of the NV center in optically detected magnetic resonance (ODMR) spectra being characteristic for various NV-13C systems.
Influence of Mediterranean Diet Adherence and Physical Activity on Bone Health in Celiac Children on a Gluten-Free Diet
Authors: Nestares Teresa , Martín-Masot Rafael , de Teresa Carlos , Bonillo Rocío , Maldonado José , Flor-Alemany Marta , Aparicio Virginia
Published: May 2021

We aimed to assess the influence of the Mediterranean Diet adherence and physical activity (PA) on body composition, with a particular focus on bone health, in young patients with celiac disease (CD). The CD group (n = 59) included children with CD with a long (>18 months, n = 41) or recent (<18 months, n = 18) adherence to a gluten-free diet (GFD). The non-celiac group (n = 40) included non-celiac children. After adjusting for potential confounders, the CD group showed lower body weight (p = 0.034), lean mass (p = 0.003), bone mineral content (p = 0.006), and bone Z-score (p = 0.036) than non-celiac children, even when the model was further adjusted for adherence to a GFD for at least 18 months. Among CD children, spending greater time in vigorous physical activity was associated with higher lean mass (p = 0.020) and bone mineral density with evidence of statistical significance (p = 0.078) regardless of the time they followed a GFD. In addition, a greater Mediterranean Diet adherence was associated with a higher bone Z-score (p = 0.020). Moreover, lean mass was strongly associated with bone mineral density and independently explained 12% of its variability (p < 0.001). These findings suggest the importance of correctly monitoring lifestyle in children with CD regarding dietary habits and PA levels to improve lean mass and, consequently, bone quality in this population.
The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections
Authors: Fortin Samantha M. , Chen Jack , Grill Harvey J. , Hayes Matthew R.
Published: May 2021

The mesencephalic trigeminal nucleus (Mes5) processes oral sensory–motor information, but its role in the control of energy balance remains unexplored. Here, using fluorescent in situ hybridization, we show that the Mes5 expresses the melanocortin-4 receptor. Consistent with MC4R activation in other areas of the brain, we found that Mes5 microinjection of the MC4R agonist melanotan-II (MTII) suppresses food intake and body weight in the mouse. Furthermore, NTS POMC-projecting neurons to the Mes5 can be chemogenetically activated to drive a suppression in food intake. Taken together, these findings highlight the Mes5 as a novel target of melanocortinergic control of food intake and body weight regulation, although elucidating the endogenous role of this circuit requires future study. While we observed the sufficiency of Mes5 MC4Rs for food intake and body weight suppression, these receptors do not appear to be necessary for food intake or body weight control. Collectively, the data presented here support the functional relevance of the NTS POMC to Mes5 projection pathway as a novel circuit that can be targeted to modulate food intake and body weight.
Effect of Maternal Nutrition on Cognitive Function of Children
Authors: Arija Victoria , Canals Josefa
Published: May 2021

The intrauterine environment and, specifically, the nutritional status of the mother are crucial factors that can have short and long-term consequences on the health and disease risk of an unborn child [...]
Human Milk from Previously COVID-19-Infected Mothers: The Effect of Pasteurization on Specific Antibodies and Neutralization Capacity
Authors: van Keulen Britt J. , Romijn Michelle , Bondt Albert , Dingess Kelly A. , Kontopodi Eva , van der Straten Karlijn , den Boer Maurits A. , Burger Judith A. , Poniman Meliawati , Bosch Berend J. , Brouwer Philip J. M. , de Groot Christianne J. M. , Hoek Max , Li Wentao , Pajkrt Dasja , Sanders Rogier W. , Schoonderwoerd Anne , Tamara Sem , Timmermans Rian A. H. , Vidarsson Gestur , Stittelaar Koert J. , Rispens Theo T. , Hettinga Kasper A. , van Gils Marit J. , Heck Albert J. R. , van Goudoever Johannes B.
Published: May 2021

Background: Since the outbreak of coronavirus disease 2019 (COVID-19), many put their hopes in the rapid availability of effective immunizations. Human milk, containing antibodies against syndrome coronavirus 2 (SARS-CoV-2), may serve as means of protection through passive immunization. We aimed to determine the presence and pseudovirus neutralization capacity of SARS-CoV-2 specific IgA in human milk of mothers who recovered from COVID-19, and the effect of pasteurization on these antibodies. Methods: This prospective case control study included lactating mothers, recovered from (suspected) COVID-19 and healthy controls. Human milk and serum samples were collected. To assess the presence of SARS-CoV-2 antibodies we used multiple complementary assays, namely ELISA with the SARS-CoV-2 spike protein (specific for IgA and IgG), receptor binding domain (RBD) and nucleocapsid (N) protein for IgG in serum, and bridging ELISA with the SARS-CoV-2 RBD and N protein for specific Ig (IgG, IgM and IgA in human milk and serum). To assess the effect of pasteurization, human milk was exposed to Holder (HoP) and High Pressure Pasteurization (HPP). Results: Human milk contained abundant SARS-CoV-2 antibodies in 83% of the proven cases and in 67% of the suspected cases. Unpasteurized milk with and without these antibodies was found to be capable of neutralizing a pseudovirus of SARS-CoV-2 in (97% and 85% of the samples respectively). After pasteurization, total IgA antibody levels were affected by HoP, while SARS-CoV-2 specific antibody levels were affected by HPP. Pseudovirus neutralizing capacity of the human milk samples was only retained with the HPP approach. No correlation was observed between milk antibody levels and neutralization capacity. Conclusions: Human milk from recovered COVID-19-infected mothers contains SARS-CoV-2 specific antibodies which maintained neutralization capacity after HPP. All together this may represent a safe and effective immunization strategy after HPP.
Cocoa Flavanols Adjuvant to an Oral Nutritional Supplement Acutely Enhances Nutritive Flow in Skeletal Muscle without Altering Leg Glucose Uptake Kinetics in Older Adults
Authors: Sian Tanvir S. , Din Ushnah S. U. , Deane Colleen S. , Smith Ken , Gates Amanda , Lund Jonathan N. , Williams John P. , Rueda Ricardo , Pereira Suzette L. , Phillips Bethan E. , Atherton Philip J.
Published: May 2021

Ageing is associated with postprandial muscle vascular and metabolic dysfunction, suggesting vascular modifying interventions may be of benefit. Reflecting this, we investigated the impact of acute cocoa flavanol (450–500 mg) intake (versus placebo control) on vascular (via ultrasound) and glucose/insulin metabolic responses (via arterialised/venous blood samples and ELISA) to an oral nutritional supplement (ONS) in twelve healthy older adults (50% male, 72 ± 4 years), in a crossover design study. The cocoa condition displayed significant increases in m. vastus lateralis microvascular blood volume (MBV) in response to feeding at 180 and 240-min after ONS consumption (baseline: 1.00 vs. 180 min: 1.09 ± 0.03, p = 0.05; 240 min: 1.13 ± 0.04, p = 0.002), with MBV at these timepoints significantly higher than in the control condition (p < 0.05). In addition, there was a trend (p = 0.058) for MBV in m. tibialis anterior to increase in response to ONS in the cocoa condition only. Leg blood flow and vascular conductance increased, and vascular resistance decreased in response to ONS (p < 0.05), but these responses were not different between conditions (p > 0.05). Similarly, glucose uptake and insulin increased in response to ONS (p < 0.05) comparably between conditions (p > 0.05). Thus, acute cocoa flavanol supplementation can potentiate oral feeding-induced increases in MBV in older adults, but this improvement does not relay to muscle glucose uptake.
Impact of Liver and Pancreas Diseases on Nutritional Status
Authors: Cañamares-Orbis Pablo , Bernal-Monterde Vanesa , Sierra-Gabarda Olivia , Casas-Deza Diego , Garcia-Rayado Guillermo , Cortes Luis , Lué Alberto
Published: May 2021

Liver and pancreatic diseases have significant consequences on nutritional status, with direct effects on clinical outcomes, survival, and quality of life. Maintaining and preserving an adequate nutritional status is crucial and should be one of the goals of patients with liver or pancreatic disease. Thus, the nutritional status of such patients should be systematically assessed at follow-up. Recently, great progress has been made in this direction, and the relevant pathophysiological mechanisms have been better established. While the spectrum of these diseases is wide, and the mechanisms of the onset of malnutrition are numerous and interrelated, clinical and nutritional manifestations are common. The main consequences include an impaired dietary intake, altered macro and micronutrient metabolism, energy metabolism disturbances, an increase in energy expenditure, nutrient malabsorption, sarcopenia, and osteopathy. In this review, we summarize the factors contributing to malnutrition, and the effects on nutritional status and clinical outcomes of liver and pancreatic diseases. We explain the current knowledge on how to assess malnutrition and the efficacy of nutritional interventions in these settings.
The Potential Health Benefits of the Ketogenic Diet: A Narrative Review
Authors: Dowis Kathryn , Banga Simran
Published: May 2021

Considering the lack of a comprehensive, multi-faceted overview of the ketogenic diet (KD) in relation to health issues, we compiled the evidence related to the use of the ketogenic diet in relation to its impact on the microbiome, the epigenome, diabetes, weight loss, cardiovascular health, and cancer. The KD diet could potentially increase genetic diversity of the microbiome and increase the ratio of Bacteroidetes to Firmicutes. The epigenome might be positively affected by the KD since it creates a signaling molecule known as β-hydroxybutyrate (BHB). KD has helped patients with diabetes reduce their HbA1c and reduce the need for insulin. There is evidence to suggest that a KD can help with weight loss, visceral adiposity, and appetite control. The evidence also suggests that eating a high-fat diet improves lipid profiles by lowering low-density lipoprotein (LDL), increasing high-density lipoprotein (HDL), and lowering triglycerides (TG). Due to the Warburg effect, the KD is used as an adjuvant treatment to starve cancer cells, making them more vulnerable to chemotherapy and radiation. The potential positive impacts of a KD on each of these areas warrant further analysis, improved studies, and well-designed randomized controlled trials to further illuminate the therapeutic possibilities provided by this dietary intervention.
Erratum: Lee et al. Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats. Nutrients 2020, 12, 2383
Authors: Lee Jee Youn , Park Chan Sol , Choi Hae Young , Chung Sung Hyun , Pyo Mi Kyung , Yune Tae Young
Published: May 2021

The authors have requested that the following changes be made to their paper [...]
Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease
Authors: Miziak Barbara , Błaszczyk Barbara , Czuczwar Stanisław J.
Published: May 2021

Alzheimer’s disease (AD; progressive neurodegenerative disorder) is associated with cognitive and functional impairment with accompanying neuropsychiatric symptoms. The available pharmacological treatment is of a symptomatic nature and, as such, it does not modify the cause of AD. The currently used drugs to enhance cognition include an N-methyl-d-aspartate receptor antagonist (memantine) and cholinesterase inhibitors. The PUBMED, Medical Subject Heading and Clinical Trials databases were used for searching relevant data. Novel treatments are focused on already approved drugs for other conditions and also searching for innovative drugs encompassing investigational compounds. Among the approved drugs, we investigated, are intranasal insulin (and other antidiabetic drugs: liraglitude, pioglitazone and metformin), bexarotene (an anti-cancer drug and a retinoid X receptor agonist) or antidepressant drugs (citalopram, escitalopram, sertraline, mirtazapine). The latter, especially when combined with antipsychotics (for instance quetiapine or risperidone), were shown to reduce neuropsychiatric symptoms in AD patients. The former enhanced cognition. Procognitive effects may be also expected with dietary antioxidative and anti-inflammatory supplements—curcumin, myricetin, and resveratrol. Considering a close relationship between brain ischemia and AD, they may also reduce post-brain ischemia neurodegeneration. An investigational compound, CN-105 (a lipoprotein E agonist), has a very good profile in AD preclinical studies, and its clinical trial for postoperative dementia is starting soon.
Chemical Classes Presenting Novel Antituberculosis Agents Currently in Different Phases of Drug Development: A 2010–2020 Review
Authors: Angula Klaudia T. , Legoabe Lesetja J. , Beteck Richard M.
Published: May 2021

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a curable airborne disease currently treated using a drug regimen consisting of four drugs. Global TB control has been a persistent challenge for many decades due to the emergence of drug-resistant Mtb strains. The duration and complexity of TB treatment are the main issues leading to treatment failures. Other challenges faced by currently deployed TB regimens include drug-drug interactions, miss-matched pharmacokinetics parameters of drugs in a regimen, and lack of activity against slow replicating sub-population. These challenges underpin the continuous search for novel TB drugs and treatment regimens. This review summarizes new TB drugs/drug candidates under development with emphasis on their chemical classes, biological targets, mode of resistance generation, and pharmacokinetic properties. As effective TB treatment requires a combination of drugs, the issue of drug-drug interaction is, therefore, of great concern; herein, we have compiled drug-drug interaction reports, as well as efficacy reports for drug combinations studies involving antitubercular agents in clinical development.
The Implications of Regulatory Framework for Topical Semisolid Drug Products: From Critical Quality and Performance Attributes towards Establishing Bioequivalence
Authors: Ilić Tanja , Pantelić Ivana , Savić Snežana
Published: May 2021

Due to complex interdependent relationships affecting their microstructure, topical semisolid drug formulations face unique obstacles to the development of generics compared to other drug products. Traditionally, establishing bioequivalence is based on comparative clinical trials, which are expensive and often associated with high degrees of variability and low sensitivity in detecting formulation differences. To address this issue, leading regulatory agencies have aimed to advance guidelines relevant to topical generics, ultimately accepting different non-clinical, in vitro/in vivo surrogate methods for topical bioequivalence assessment. Unfortunately, according to both industry and academia stakeholders, these efforts are far from flawless, and often upsurge the potential for result variability and a number of other failure modes. This paper offers a comprehensive review of the literature focused on amending regulatory positions concerning the demonstration of (i) extended pharmaceutical equivalence and (ii) equivalence with respect to the efficacy of topical semisolids. The proposed corrective measures are disclosed and critically discussed, as they span from mere demands to widen the acceptance range (e.g., from ±10% to ±20%/±25% for rheology and in vitro release parameters highly prone to batch-to-batch variability) or reassess the optimal number of samples required to reach the desired statistical power, but also rely on specific data modeling or novel statistical approaches.
Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
Authors: Gonçalves José L. M. , Lopes Ana Beatriz C. , Baleizão Carlos , Farinha José Paulo S.
Published: May 2021

Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the system was optimized by a novel approach using selective functionalization of the silica pores to tune the carrier-cargo interaction and by tunning the amount of grafted polymer. The system features excellent retention of cationic cargo at low pH and a burst release at higher pH. This results from the expanded-collapsed conformation transition of the pH-responsive polymer shell and the simultaneous change in the interaction between the cargo and the polymer shell and the modified pore walls. At low pH, the electrostatic interaction of the cationic cargo with the protonated amine groups of the extended polymer shell retains the cargo, resulting in very low leakage (OFF state). At high pH, the electrostatic interaction with the cargo is lost (due to deprotonation of the polymer amine groups), and the polymer shell collapses, squeezing out the cargo in a burst release (ON state). Pore functionalization in combination with the stimuli-responsive polymer shell is a very promising strategy to design high-performance ON:OFF smart hybrid nanocarriers for stimuli-actuated cargo release, with great potential for application in the controlled release of drugs and other biologically active agents.
Towards Biological Control of Aspergillus carbonarius and Botrytis cinerea in Grapevine Berries and Transcriptomic Changes of Genes Encoding Pathogenesis-Related (PR) Proteins
Authors: Gkizi Danai , Poulaki Eirini G. , Tjamos Sotirios E.
Published: May 2021

Grapevine bunch rot, caused by Botrytis cinerea and Aspergillus carbonarius, causes important economic losses every year in grape production. In the present study, we examined the plant protective activity of the biological control agents, Paenibacillus alvei K165, Blastobotrys sp. FP12 and Arthrobacter sp. FP15 against B. cinerea and A. carbonarius on grapes. The in vitro experiments showed that strain K165 significantly reduced the growth of both fungi, while FP15 restricted the growth of A. carbonarius and FP12 was ineffective. Following the in vitro experiments, we conducted in planta experiments on grape berries. It was shown that K165, FP12 and FP15 reduced A. carbonarius rot severity by 81%, 57% and 37%, respectively, compared to the control, whereas, in the case of B. cinerea, the only protective treatment was that with K165, which reduced rot by 75%. The transcriptomic analysis of the genes encoding the pathogenesis-related proteins PR2, PR3, PR4 and PR5 indicates the activation of multiple defense responses involved in the biocontrol activity of the examined biocontrol agents.
Identification of QTLs for Spot Blotch Resistance in Two Bi-Parental Mapping Populations of Wheat
Authors: Gahtyari Navin C. , Roy Chandan , He Xinyao , Roy Krishna K. , Reza Mohamed M. A. , Hakim Md. A. , Malaker Paritosh K. , Joshi Arun K. , Singh Pawan K.
Published: May 2021

Spot blotch (SB) disease caused by the hemibiotrophic pathogen Bipolaris sorokiniana inflicting major losses to the wheat grown in warm and highly humid areas of the Indian subcontinent, including Bangladesh, necessitates identification of QTLs stably expressing in Indian subcontinent conditions. Thus, two RIL mapping populations, i.e., WC (WUYA × CIANO T79) and KC (KATH × CIANO T79), were phenotyped at Dinajpur, Bangladesh for three consecutive years (2013-2015) and genotyped on a DArTseq genotyping by sequencing (GBS) platform at CIMMYT, Mexico. In both populations, quantitative inheritance along with transgressive segregation for SB resistance was identified. The identified QTLs were mostly minor and were detected on 10 chromosomes, i.e., 1A, 1B, 2A, 2B, 2D, 4B, 4D, 5A, 5D, and 7B. The phenotypic variation explained by the identified QTLs ranged from 2.3–15.0%, whereby QTLs on 4B (13.7%) and 5D (15.0%) were the largest in effect. The identified QTLs upon stacking showed an additive effect in lowering the SB score in both populations. The probable presence of newly identified Sb4 and durable resistance gene Lr46 in the identified QTL regions indicates the importance of these genes in breeding for SB resistance in Bangladesh and the whole of South Asia.
Match Algorithms for Scientific Names in FlorItaly, the Portal to the Flora of Italy
Authors: Conti Matteo , Nimis Pier Luigi , Martellos Stefano
Published: May 2021

Scientific names are not part of everyday language in any modern country, and their input as strings in a query system can be easily associated with typographical errors. While globally unique identifiers univocally address a taxon name, they can hardly be used for querying a database manually. Thus, matching algorithms are often used to overcome misspelled names in query systems in several data repositories worldwide. In order to improve users’ experience in the use of FlorItaly, the Portal to the Flora of Italy, a near match algorithm to resolve misspelled scientific names has been integrated in the query systems. In addition, a novel tool in FlorItaly, capable of rapidly aligning any list of names to the nomenclatural backbone provided by the national checklists, has been developed. This manuscript aims at describing the potential of these new tools.
Effects of Association of Barley Plants with Hydrocarbon-Degrading Bacteria on the Content of Soluble Organic Compounds in Clean and Oil-Contaminated Sand
Authors: Chetverikov Sergey , Vysotskaya Lidiya , Kuzina Elena , Arkhipova Tatiana , Bakaeva Margarita , Rafikova Gulnaz , Korshunova Tatiana , Chetverikova Darya , Hkudaygulov Gaisar , Kudoyarova Guzel
Published: May 2021

Plant-bacteria consortia are more effective in bioremediation of petroleum contaminated soil than when either organism is used individually. The reason for this is that plant root exudates promote growth and activity of oil degrading bacteria. However, insufficient attention has been paid to the ability of bacteria to influence root exudation. Therefore, the influence of barley plants and/or bacterial inoculation (Pseudomonas hunanensis IB C7 and Enterobacter sp. UOM 3) on the content of organic acids, sugars and plant hormones in the eluate from clean and oil-polluted sand was studied separately or in combination. These strains are capable of oxidizing hydrocarbons and synthesizing auxins. Concentrations of organic acids and sugars were determined using capillary electrophoresis, and hormones by enzyme-linked immunosorbent assays. In the absence of plants, no sugars were detected in the sand, confirming that root exudates are their main source. Introducing bacteria into the sand increased total contents of organic compounds both in the presence and absence of oil. This increase could be related to the increase in auxin amounts in the sand eluate, as well as in plants. The results indicate that bacteria are able to increase the level of root exudation. Since auxins can promote root exudation, bacterial production of this hormone is likely responsible for increased concentrations of soluble organic compounds in the sand. Bacterial mediation of root exudation by affecting plant hormonal status should be considered when choosing microorganisms for phytoremediation.
Hard Coating Materials Based on Photo-Reactive Silsesquioxane for Flexible Application: Improvement of Flexible and Hardness Properties by High Molecular Weight
Authors: Leem Jong Tae , Seok Woong Cheol , Yoo Ji Beom , Lee Sangkug , Song Ho Jun
Published: May 2021

EPOSS of polyhedral oligomeric silsesquioxanes (POSS) mixture structure and LPSQ of ladder-like polysilsesquioxane (LPSQ) structure were synthesized via sol–gel reaction. EPSQ had a high molecular weight due to polycondensation by potassium carbonate. The EPSQ film showed uniform surface morphology due to regular double-stranded structure. In contrast, the EPOSS-coated film showed nonuniform surface morphology due to strong aggregation. Due to the aggregation, the EPOSS film had shorter d-spacing (d1) than the EPSQ film in XRD analysis. In pencil hardness and nanoindentation analysis, EPSQ film showed higher hardness than the EPOSS film due to regular double-stranded structure. In addition, in the in-folding (r = 0.5 mm) and out-folding (r = 5 mm) tests, the EPSQ film did not crack unlike the EPOSS coated film.
Chemistry, Processing, Properties, and Applications of Rubber Foams
Authors: Rostami-Tapeh-Esmaeil Ehsan , Vahidifar Ali , Esmizadeh Elnaz , Rodrigue Denis
Published: May 2021

With the ever-increasing development in science and technology, as well as social awareness, more requirements are imposed on the production and property of all materials, especially polymeric foams. In particular, rubber foams, compared to thermoplastic foams in general, have higher flexibility, resistance to abrasion, energy absorption capabilities, strength-to-weight ratio and tensile strength leading to their widespread use in several applications such as thermal insulation, energy absorption, pressure sensors, absorbents, etc. To control the rubber foams microstructure leading to excellent physical and mechanical properties, two types of parameters play important roles. The first category is related to formulation including the rubber (type and grade), as well as the type and content of accelerators, fillers, and foaming agents. The second category is associated to processing parameters such as the processing method (injection, extrusion, compression, etc.), as well as different conditions related to foaming (temperature, pressure and number of stage) and curing (temperature, time and precuring time). This review presents the different parameters involved and discusses their effect on the morphological, physical, and mechanical properties of rubber foams. Although several studies have been published on rubber foams, very few papers reviewed the subject and compared the results available. In this review, the most recent works on rubber foams have been collected to provide a general overview on different types of rubber foams from their preparation to their final application. Detailed information on formulation, curing and foaming chemistry, production methods, morphology, properties, and applications is presented and discussed.
Confined Plunging Liquid Jets for Dilution of Brine from Desalination Plants
Authors: Shrivastava Ishita , Adams Edward Eric , Al-Anzi Bader , Chow Aaron Chunghin , Han Jongyoon
Published: May 2021

Confined plunging jets are investigated as potential outfalls for the discharge of desalination brine. Compared to offshore submerged outfalls that rely on momentum to induce mixing, plunging jets released above the water surface utilize both momentum and negative buoyancy. Plunging jets also introduce air into the water column, which can reduce the possibility of hypoxic zones. In contrast to unconfined plunging jets, confined plunging jets include a confining tube, or downcomer, around the jet, which increases the penetration depth of the bubbles and can provide better aeration. However, the presence of this downcomer can hinder mixing with surrounding water. Therefore, laboratory measurements of dilution are reported here and compared to the dilution of unconfined plunging jets. In addition, qualitative observations of bubble penetration depth are also used to discuss aeration potential. For designs that increase the bubble penetration depth as compared to unconfined plunging jets, results show that dilution decreases as the depth of the downcomer is increased. However, it is shown that confined plunging jets can be designed with a short downcomer to provide higher dilution than unconfined jets. The effect of the diameter of downcomer on dilution is also investigated and a non-monotonic effect is observed.
Material Generation Algorithm: A Novel Metaheuristic Algorithm for Optimization of Engineering Problems
Authors: Talatahari Siamak , Azizi Mahdi , Gandomi Amir H.
Published: May 2021

A new algorithm, Material Generation Algorithm (MGA), was developed and applied for the optimum design of engineering problems. Some advanced and basic aspects of material chemistry, specifically the configuration of chemical compounds and chemical reactions in producing new materials, are determined as inspirational concepts of the MGA. For numerical investigations purposes, 10 constrained optimization problems in different dimensions of 10, 30, 50, and 100, which have been benchmarked by the Competitions on Evolutionary Computation (CEC), are selected as test examples while 15 of the well-known engineering design problems are also determined to evaluate the overall performance of the proposed method. The best results of different classical and new metaheuristic optimization algorithms in dealing with the selected problems were taken from the recent literature for comparison with MGA. Additionally, the statistical values of the MGA algorithm, consisting of the mean, worst, and standard deviation, were calculated and compared to the results of other metaheuristic algorithms. Overall, this work demonstrates that the proposed MGA is able provide very competitive, and even outstanding, results and mostly outperforms other metaheuristics.
Effects of Fin Arrangements on Thermal Hydraulic Performance of Supercritical Nitrogen in Printed Circuit Heat Exchanger
Authors: Yang Shan , Zhao Zhongchao , Zhang Yong , Chen Zhengchao , Yang Min
Published: May 2021

The printed circuit heat exchanger (PCHE) with discontinuous fins is a novel type of compact and highly efficient plate heat exchanger, which has superior thermal hydraulic performance. The morphology and characteristics of the flow channel greatly affect the performance of the PCHE. The discontinuous airfoil fins are used in PCHE channel design because they can affect the flow and heat transfer by increasing the heat transfer area and the disturbance in the channel. In this paper, the effects of different staggered distance (Ls) and transverse distance (Lv) of airfoil fin arrangements on the heat transfer and flow of supercritical nitrogen in the PCHE are numerically simulated using ANSYS Fluent. Simulation results and subsequent analysis show that the appropriate decrease in Ls and reduction in Lv between the two rows of fins can improve the convective heat transfer of the PCHE. A fully staggered arrangement of fins (Ls = 1.2) and an appropriate increase in the Lv can mitigate pressure drop. The comprehensive performance of different channel geometries is compared by the performance evaluation criteria (PEC) in this study. It is shown that considering flow resistance and heat transfer, the comprehensive heat transfer performance can be enhanced by properly increasing the staggered distance and the vertical distance between fins. When Ls = 1.2 mm and Lv = 1.25 mm, the PEC value of the staggered channel is the highest, which is 11.6% higher than that of the parallel channel on average.
Factors to Improve Publication Productivity in Russian Universities
Authors: Vasiljeva Мarina V. , Osipov Gennady V. , Ponkratov Vadim V. , Ivlev Vitali Ju. , Ivleva Marina I. , Karepova Svetlana G. , Gardanova Zhanna R. , Dudnik Olesya V.
Published: May 2021

One of the most important conditions for the effectiveness of science is the motivation of academic staff of universities as key and direct producers of new knowledge. The purpose of the article was to substantiate the factors of efficiency in managing the publication activity of Russian universities. The nature and density of the relationship between the number of scientific publications and the level of citation of 19 leading countries in the world, including Russia, were determined by means of statistical analysis and the method of clusters. It has been empirically proven that the priority model for the development of publication activity should be an intensive model, which aims at improving the quality of scientific publications and the level of their citation. Moreover, a survey of 1573 young scientists (under the age of 39) and 2461 senior scientists from 14 universities in Russia was conducted. It investigated the factors of effective management of the publication activity at Russian universities. The results contribute to a better understanding on how Russian universities can activate and foster the flow of high-quality publication outputs by their researchers.
A Comparative Analysis of Berith and the Sacrament of Baptism and How They Contributed to the Inquisition
Authors: Elazar-DeMota Yehonatan
Published: May 2021

In 1391 Spanish Jews were forcibly converted to Catholic Christianity, and Portuguese Jews suffered the same fate in 1497. Jewish law rendered involuntary converts as anusim and voluntary converts as meshumadim. Christians without Jewish ancestry called them by various names, New Christians, alboraique, xuetas, and marranos, to name a few. In the fifteenth century, Catholic clerical authorities debated whether the New Christians were indeed Christians, albeit coerced. Canonic law rendered the sacrament of baptism as irrevocable. As such, any belief or practice not in accordance with Catholic doctrine was tantamount to heresy. Consequently, the Inquisition sought to rid the Church of the “Judaizing heresy.” On the one hand, the Sinaitic covenant (berith) considered anusim as Jews, even though there were Christians. This paper analyzes Jewish law and canonic law on respective religious identities. It includes an examination of rabbinic texts and rabbinic responsa, and an examination of the sacrament of Christian baptism. Both religious traditions fought for the souls of the anusim, characterizing what Victor Turner calls liminality and communitas.
Combination of Sentinel-2 and PALSAR-2 for Local Climate Zone Classification: A Case Study of Nanchang, China
Authors: Chen Chaomin , Bagan Hasi , Xie Xuan , La Yune , Yamagata Yoshiki
Published: May 2021

Local climate zone (LCZ) maps have been used widely to study urban structures and urban heat islands. Because remote sensing data enable automated LCZ mapping on a large scale, there is a need to evaluate how well remote sensing resources can produce fine LCZ maps to assess urban thermal environments. In this study, we combined Sentinel-2 multispectral imagery and dual-polarized (HH + HV) PALSAR-2 data to generate LCZ maps of Nanchang, China using a random forest classifier and a grid-cell-based method. We then used the classifier to evaluate the importance scores of different input features (Sentinel-2 bands, PALSAR-2 channels, and textural features) for the classification model and their contribution to each LCZ class. Finally, we investigated the relationship between LCZs and land surface temperatures (LSTs) derived from summer nighttime ASTER thermal imagery by spatial statistical analysis. The highest classification accuracy was 89.96% when all features were used, which highlighted the potential of Sentinel-2 and dual-polarized PALSAR-2 data. The most important input feature was the short-wave infrared-2 band of Sentinel-2. The spectral reflectance was more important than polarimetric and textural features in LCZ classification. PALSAR-2 data were beneficial for several land cover LCZ types when Sentinel-2 and PALSAR-2 were combined. Summer nighttime LSTs in most LCZs differed significantly from each other. Results also demonstrated that grid-cell processing provided more homogeneous LCZ maps than the usual resampling methods. This study provided a promising reference to further improve LCZ classification and quantitative analysis of local climate.
New Inventories of Global Carbon Dioxide Emissions through Biomass Burning in 2001–2020
Authors: Shiraishi Tomohiro , Hirata Ryuichi , Hirano Takashi
Published: May 2021

Recently, the effect of large-scale fires on the global environment has attracted attention. Satellite observation data are used for global estimation of fire CO2 emissions, and available data sources are increasing. Although several CO2 emission inventories have already been released, various remote sensing data were used to create the inventories depend on the studies. We created eight global CO2 emission inventories through fires from 2001 to 2020 by combining input data sources, compared them with previous studies, and evaluated the effect of input sources on CO2 emission estimation. CO2 emissions were estimated using a method that combines the biomass density change (by the repeated fires) with the general burned area approach. The average annual CO2 emissions of the created eight inventories were 8.40 ± 0.70 Pg CO2 year−1 (±1 standard deviation), and the minimum and maximum emissions were 3.60 ± 0.67 and 14.5 ± 0.83 Pg CO2 year−1, respectively, indicating high uncertainty. CO2 Emissions obtained from four previous inventories were within ±1 standard deviation in the eight inventories created in this study. Input datasets, especially biomass density, affected CO2 emission estimation. The global annual CO2 emissions from two biomass maps differed by 60% (Maximum). This study assesses the performance of climate and fire models by revealing the uncertainty of fire emission estimation from the input sources.
An Instance Segmentation-Based Method to Obtain the Leaf Age and Plant Centre of Weeds in Complex Field Environments
Authors: Quan Longzhe , Wu Bing , Mao Shouren , Yang Chunjie , Li Hengda
Published: May 2021

Leaf age and plant centre are important phenotypic information of weeds, and accurate identification of them plays an important role in understanding the morphological structure of weeds, guiding precise targeted spraying and reducing the use of herbicides. In this work, a weed segmentation method based on BlendMask is proposed to obtain the phenotypic information of weeds under complex field conditions. This study collected images from different angles (front, side, and top views) of three kinds of weeds (Solanum nigrum, barnyard grass (Echinochloa crus-galli), and Abutilon theophrasti Medicus) in a maize field. Two datasets (with and without data enhancement) and two backbone networks (ResNet50 and ResNet101) were replaced to improve model performance. Finally, seven evaluation indicators are used to evaluate the segmentation results of the model under different angles. The results indicated that data enhancement and ResNet101 as the backbone network could enhance the model performance. The F1 value of the plant centre is 0.9330, and the recognition accuracy of leaf age can reach 0.957. The mIOU value of the top view is 0.642. Therefore, deep learning methods can effectively identify weed leaf age and plant centre, which is of great significance for variable spraying.