bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism of Filtration Behaviors of Cement-Based Grout in Saturated Sand under Different Grouting Conditions
Authors: Xu Shanlin , Cao Hongtao , Zhu Yanzhen , Sun Honglei , Lu Jingling , Shi Junqiang
Published: May 2022

Cement-based grout has been widely used in various civil engineering applications. However, the filtration behaviors of it when grouting the porous geological masses vary a lot under different grouting conditions, which significantly influences its penetration and the enhancement effect. The purpose of this work was to better understand the filtration of cement-based grout in porous sand by conducting a series of visualized laboratory tests and EDTA titration tests. The experimental results show that the cement filtration, including the penetration, retention, and formation of cement filter cake above the grouting body, is collectively influenced by different grouting factors. With the increase of the soil samples’ pore size and the cement slurry’s water-cement ratio, the penetrated distance and amount of cement in sand increase. However, the penetration does not increase monotonically with the grouting pressure. Too excessive grouting pressure (e.g., 300 kPa in this study) accelerates the formation of cement filter cake and thus stops the subsequent cement infiltration. The mechanisms of different filtration behaviors were explained from microscopic particle clogging in the pore throat of the porous media. Furthermore, the reduced permeability of the sand column with the retained cement due to filtration was discussed, and the dewatering phenomenon of the cement slurry after filter cake formation was first revealed.
Analysis of Human Reliability in Fever Clinics during the Epidemic Based on the DEMATEL Method
Authors: Lin Ange , Chen Xiongfeng
Published: May 2022

Objective. To explore the method and process of human reliability analysis in epidemic prevention and control system in the complex environment of fever clinics. Methods. Based on the actual situation in the fever clinic of a level A tertiary hospital in Wenzhou, factors that affect clinical safety are sorted out. The Delphi method is used when evaluating the interrelationship among the contributing factors, and then, the DEMATEL method is used to further sort it out to build an impact model. Finally, the data of the experimental model are analyzed, and the impact of factors on human reliability is summarized. Results. Through the data analysis of 23 factors in the fever clinic of the hospital, the impact, prominence, and relation of each factor are confirmed. It is concluded that layout design, disinfection, and isolation setting and on-the-job training are the core factors impacting the operation of the fever clinic. Conclusion. Conducting a human factor reliability analysis with the help of the DEMATEL method can quantitatively describe the influence and interrelationship of human factors in epidemic prevention and control system and effectively promote the safety enhancement of fever clinics.
Sea Experimental for Compressive Sensing-Based Sparse Channel Estimation of Underwater Acoustic TDS-OFDM System
Authors: Junejo Naveed Ur Rehman , Esmaiel Hamada , Sattar Mariyam , Sun Haixin , Khalil Muhammad Amir , Ullah Ihsan
Published: May 2022

Due to the high spectral efficiency (SE) and fast synchronization, the time-domain synchronization orthogonal frequency division multiplexing (TDS-OFDM) system has gotten much more attraction of researchers as compared to cyclic-prefix (CP) and zero padding (ZP) OFDM in terrestrial as well as underwater acoustic communication. Inter-block interference (IBI) degrades the TDS-OFDM performance due to its long-delay multiple channels. In TDS-OFDM, dual pseudo-random noise (DPN) sequences utilize two PN sequences as a guard interval (GI) after every data block to cope with interference from the OFDM data block to the next PN sequence resulting in compromising the energy efficiency (EE) and spectral efficiency. We have proposed compressed sensing-based technique compressive sensing matching pursuit (CoSaMP), orthogonal matching pursuit (OMP), and look-ahead and backtracking OMP (LABOMP) for TDS-OFDM over the real-time underwater channel in this paper. Moreover, prior to estimating the channel, the received PN sequence is considered in the time domain to compensate for the Doppler shift of the UWA channel. The real-time data experiment has been initially conducted for testing in a water tank in our laboratory. Furthermore, it has been tested on the sea for long communications under the water at the Wuyuan sea area in Xiamen, China. Simulations and experimental results evident that the compressed sensing techniques have better performance over the conventional TDS-OFDM and DPN-TDS-OFDM, even LABOMP outperform OMP and CoSaMP in terms of bit-error-rate (BER), SE, and EE.
Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis
Authors: Cui Leilei , Bai Zhaoliang
Published: May 2022

Objective. To explore the effect of a moxibustion instrument combined with intermediate frequency electrostatic therapy on pain and joint function in elderly patients with cold-dampness arthritis (KOA). Method. 200 patients with cold-dampness KOA treated in our hospital from May 2019 to September 2021 were selected. According to the random number table method, they were divided into the observation group (

n
=
100

) and control group (

n
=
100

). The observation group was treated with moxibustion combined with medium-frequency treatment, and the control group was treated with medium-frequency treatment. The clinical effects of the two groups were compared. The joint functions of the two groups were evaluated by the visualization scale of the osteoarthritis index (WOMAC index) of McMaster University in Western Ontario. The TCM symptom scores of the two groups were evaluated according to the guiding principles for clinical research of new traditional Chinese medicine. The visual analogue scale (VAS) was used to evaluate the pain degree of the two groups, and the microcirculatory blood perfusion (MBPU) and interleukin-1 were compared between the two groups, β (IL-1β) and tumor necrosis factor-α (TNF-α). The levels of matrix metalloproteinase-1 (MMP-1), serum bone morphogenetic protein-2 (BMP-2), cartilage oligomeric matrix protein (COMP), and serum type II collagen C-terminal peptide (CTX-II) were assessed by the comprehensive quality of life questionnaire-74. Result. The total effective rate of the observation group (92.00%) was higher than that of the control group (76.00%), and the difference was statistically significant (

P
<
0.05

) in β and TNF-α. The levels of MMP-3, BMP-2, comp, and CTX-II and the improvement of quality of life score in the control group were better than those in the control group (

P
<
0.05

). Conclusion. Moxibustion instrument combined with intermediate frequency electrostatic therapy can effectively improve the knee joint function, pain, blood perfusion, inflammatory reaction, and cartilage damage of the elderly patients with cold-dampness-type knee arthritis, and the therapeutic effect is good.
Some Novel Analytical Approximations to the (Un)damped Duffing–Mathieu Oscillators
Authors: Alyousef Haifa A. , Salas Alvaro H. , Alkhateeb Sadah A. , El-Tantawy S. A.
Published: May 2022

Some novel exact solutions and approximations to the damped Duffing–Mathieu‐type oscillator with cubic nonlinearity are obtained. This work is divided into two parts: in the first part, some exact solutions to both damped and undamped Mathieu oscillators are obtained. These solutions are expressed in terms of the Mathieu functions of the first kind. In the second part, the equation of motion to the damped Duffing–Mathieu equation (dDME) is solved using some effective and highly accurate approaches. In the first approach, the nonintegrable dDME with cubic nonlinearity is reduced to the integrable dDME with linear term having undermined optimal parameter (maybe called reduced method). Using a suitable technique, we can determine the value of the optimal parameter and then an analytical approximation is obtained in terms of the Mathieu functions. In the second approach, the ansatz method is employed for deriving an analytical approximation in terms of trigonometric functions. In the third approach, the homotopy perturbation technique with the extended Krylov–Bogoliubov–Mitropolskii (HKBM) method is applied to find an analytical approximation to the dDME. Furthermore, the dDME is solved numerically using the Runge–Kutta (RK) numerical method. The comparison between the analytical and numerical approximations is carried out. All obtained approximations can help a large number of researchers interested in studying the nonlinear oscillations and waves in plasma physics and many other fields because many evolution equations related to the nonlinear waves and oscillations in a plasma can be reduced to the family of Mathieu‐type equation, Duffing‐type equation, etc.
The Effects of Magneto-Radiative Parameters on the Heat Transfer Mechanism in H2O Composed by Cu-Al2O3 Hybrid Nanomaterial: Numerical Investigation
Authors: Khan Wahid , Khan Umar , Adnan  , Ullah Basharat , Ahmed Naveed , Khan Ilyas , Alqahtani Aisha M. , Alam Md. Nur
Published: May 2022

The analysis of thermal performance in second generation of nanofluids (hybrid nanofluids) attained much attention of the researchers, scientists, engineers, and industrialists. These fluids have ultra-high thermal characteristics due to which their broad applications could be found in many areas of technological world. Therefore, a novel analysis regarding the heat transfer is conducted over a stretched surface by considering combined convection, thermal radiations, and magnetic field. The hybrid nanofluid is synthesized by Cu-Al2O3 guest hybrid-nanomaterial and host liquid H2O. The hybrid flow model is solved numerically and decorated the results over the region of interest. It is drawn that the velocity drops by increasing the strength of Cu-Al2O3 fraction and applied Lorentz forces. Furthermore, the thermal performance of Cu-Al2O3/H2O augmented against stronger thermal radiations, volumetric fraction, and magnetic field effects.
Hematological Parameters in Individuals with Beta Thalassemia Trait in South Sumatra, Indonesia
Authors: Sari Dian Puspita , Wahidiyat Pustika Amalia , Setianingsih Iswari , Timan Ina S. , Gatot Djajadiman , Kekalih Aria
Published: May 2022

Background. β-Thalassemia has a very wide clinical variation, depending on the severity of the patient’s condition. Individuals with β-thalassemia traits are usually asymptomatic; however, laboratory examination will show mild anemia with microcytic hypochromic erythrocytes morphology with wide variation depending on the genotype. This study was conducted to determine the reference value of hematological parameters and hemoglobin (Hb) analysis based on the phenotype of β-thalassemia (β0 and β+) and determine the differences of hematological characteristics between the two phenotypes. Methods. This cross-sectional study was conducted by evaluating the hematological parameters and Hb analysis of the β-thalassemia trait in the family of thalassemia patient population. The subjects were divided into β0 and β+. The subject with normal Hb analysis with or without iron deficiency was excluded. Results. A total of 203 subjects with thalassemia traits were included from the families of thalassemia patients, consisting of 101 subjects with β0-thalassemia, 82 subjects with β+-thalassemia, and the mutation had not been found in 20 subjects. There was a relationship in the mean/median of hematological parameters, HbA2 and HbF, between β0-thalassemia and β+-thalassemia (

P
<
0.05

). ROC for each hematological parameter, HbA2 and HbF, showed that the highest diagnostic value based on the area under the curve was mean corpuscular hemoglobin (MCH) (0.900) and mean corpuscular volume (MCV) (0.898). The cutoff point of MCH for β0-thalassemia trait was ≤20.5 pg (sensitivity 85%, specificity 90%) and MCV was ≤66.8 fL (sensitivity 87%, specificity 87%). Conclusion. MCH values can be used as a screening tool for predicting β0-thalassemia in the relatives of thalassemia patients in the South Sumatra population.
Pregnancy-Associated Sacroiliitis following an Uncomplicated Pregnancy
Authors: Ahmadi Maryam , Abiri Farid , Ahmadiani Somaieh , Jenabi Ensiyeh
Published: May 2022

Pregnancy-associated sacroiliitis is infrequent during the peripartum period. Although pregnancy-associated pyogenic sacroiliitis rarely occurs, it is associated with significant morbidity and mortality. A timely diagnosis of the disease is challenging due to its nonspecific clinical symptoms. We reviewed a case that experienced an acute illness during pregnancy. The illness was manifested by localized pain in the hips or buttocks, sacroiliac joint tenderness, and debilitating hip pain during ambulation. Magnetic resonance imaging revealed little joint involvement, and the patient was treated with antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and glucocorticoids. The patient responded well to the therapy with marked improvement in her ambulation. Septic sacroiliitis should be considered in peripartum patients presenting with increased inflammatory markers and severe localized pain. Medical management is usually curative and without an adverse effect on pregnancy. Although we could not perform a biopsy to verify the cause of the disease, the patient’s excellent response to the treatment confirmed our diagnosis.
[Retracted] Deep Transfer Learning‐Based Breast Cancer Detection and Classification Model Using Photoacoustic Multimodal Images
Authors: Althobaiti Maha M. , Ashour Amal Adnan , Alhindi Nada A. , Althobaiti Asim , Mansour Romany F. , Gupta Deepak , Khanna Ashish
Published: May 2022

The rapid development of technologies in biomedical research has enriched and broadened the range of medical equipment. Magnetic resonance imaging, ultrasonic imaging, and optical imaging have been discovered by diverse research communities to design multimodal systems, which is essential for biomedical applications. One of the important tools is photoacoustic multimodal imaging (PAMI) which combines the concepts of optics and ultrasonic systems. At the same time, earlier detection of breast cancer becomes essential to reduce mortality. The recent advancements of deep learning (DL) models enable detection and classification the breast cancer using biomedical images. This article introduces a novel social engineering optimization with deep transfer learning‐based breast cancer detection and classification (SEODTL‐BDC) model using PAI. The intention of the SEODTL‐BDC technique is to detect and categorize the presence of breast cancer using ultrasound images. Primarily, bilateral filtering (BF) is applied as an image preprocessing technique to remove noise. Besides, a lightweight LEDNet model is employed for the segmentation of biomedical images. In addition, residual network (ResNet‐18) model can be utilized as a feature extractor. Finally, SEO with recurrent neural network (RNN) model, named SEO‐RNN classifier, is applied to allot proper class labels to the biomedical images. The performance validation of the SEODTL‐BDC technique is carried out using benchmark dataset and the experimental outcomes pointed out the supremacy of the SEODTL‐BDC approach over the existing methods.
Knowledge, Attitude, Practices, and Associated Factor towards Hepatitis B Virus Infection among Health Care Professionals at Tibebe Ghion Specialized Hospital, Bahir Dar, Northwest Ethiopia, 2021: A Cross Sectional Study
Authors: Belete Debaka , Wondale Dagnaneh , Kiros Teklehaimanot , Demissie Biruk
Published: May 2022

Background. Hepatitis B virus (HBV) infection is the major infectious hazard for health care personnel. The global prevalence of HBV infection is highly heterogeneous, and the highest prevalence (6.2 and 6.1%) is among the World Health Organization Western Pacific and World Health Organization African regions, respectively. The pooled prevalence of HBV in Ethiopia among health workers was accounted for 5%. The prevalence rate of HBV in health care workers is about 2–10 times higher than the general population in the world. There for, the main aim of this study was to assess the knowledge, attitude and practice, and associated factors towards hepatitis B virus (HBV) infection among health care professionals at Tibebe Ghion Specialized Hospital, Bahir Dar, Northwest Ethiopia, 2021. Method. An institutional-based cross-sectional study design was at Tibebe Ghion Specialized Hospital, Bahir Dar, in 2021, and a systematic random sampling technique was used from different professionals, and the separate sample was taken independently from each. A pretested structured questionnaire was constructed and collects data then analyzed by using SPSS version 23. Result. A total of 422 health care workers having different professions have participated in this study. 243 (57.6%) of the study subjects were males. The average correctly answered knowledge, attitude, and practice questions were 65.6%, 40.3%, and 34.8, respectively. Multivariable logistic regression analysis showed that being nurse professionals (

A
O
R
=
0.17

(0.07, 0.38),

P
<
0.001

), midwives (

A
O
R
=
0.19

(0.07, 0.5),

P
=
0.001

), and work experience (

A
O
R
=
2.37

(1.38, 4.02),

P
=
0.002

) were associated with knowledge levels. Being degree holders (

A
O
R
=
2.49

(1.23, 5.02),

P
=
0.01

) and specialists (

A
O
R
=
9.78

(2.69, 35.5),

P
=
0.001

) were associated with attitude levels. Being medical laboratories (

A
O
R
=
17.42

(5.02, 60.5),

P
≤
0.001

) and pharmacy professionals (

A
O
R
=
11.2

(4.02, 31.42),

P
≤
0.001

) were associated with practice levels. Conclusion and Recommendation. Based on the current study, most of the health care professionals in this study area have poor knowledge, negative attitude, and malpractice towards HBV infection. Therefore, continual professional training programs on HBV infection include increased vaccination coverage rate and postexposure prophylaxis of heath care workers especially for highly exposed professionals.
Study on the Features of Clinical Imaging Diagnosis of Arteriosclerotic Encephalopathy
Authors: Tang Wenbo , Du Xiaoying , Wang Wei , Shan Erbo , Nie Zhonglin , Yu Chaowen , Gao Yong
Published: May 2022

This paper discusses the imaging diagnostic features of arteriosclerotic encephalopathy and combines the spatial context information of local features to study the clinical imaging image copy detection algorithm. Moreover, this paper proposes a clinical imaging copy detection algorithm that combines the BOW model and spatial context embedding and a clinical imaging copy detection algorithm that combines the BOW model and global context verification. In addition, this paper applies the algorithm to the imaging diagnostic features of arteriosclerotic encephalopathy and sets up a controlled experiment to start research. The experimental research shows that the application of imaging diagnosis to the detection of subcortical arteriosclerotic encephalopathy has good clinical effects and rapid remission of patients’ symptoms. The effectiveness of this method can be verified by a large number of clinical practices in follow-up studies.
An Intelligent Identification and Repair Method for Annular Holes in 3D Printing
Authors: Zhang Shanhui , Wu Wei , Wei Wei
Published: May 2022

With the popularization of 3D printing in the consumer goods field, there is a specific type of hole named annular hole in the narrow features, surface bumps, or folded parts of products. The traditional triangular mesh repair method is not effective for such holes. The structural characteristics of the annular hole are analyzed in this research, and the definition and identification method for annular holes is presented through the shape and position relationship of two closed hole lines. To improve the repair efficiency and the applicability of the algorithm, the traditional hole repair method and process are ameliorated. A repair strategy of hole boundary stitching and filling, triangulation optimization, implicit surface construction based on Radial Basis Function, and surface integral deformation is adopted to achieve a smooth joint of the repaired hole surface with the original triangular mesh surface. The method can ensure surface smoothness and accuracy. Finally, two experiments are carried out to verify the repair quality and efficiency of our method. Compared with Geomagic software, the proposed method can automatically identify and repair annular holes with fewer defects and similar efficiency. Compared with a traditional hole repair method, the evaluation results demonstrate that the proposed method is much faster, and the repair quality is higher without the influences of human operations. It is shown that our method can be applied to annular hole repair of 3D printing models without the participation of technicians.
Diagnostic Value and Clinical Performance of Cardiac Ultrasound in Patients with Chronic Heart Failure with Hypertension
Authors: Li Punan , Zhang Xiaoli
Published: May 2022

Objective. To assess the diagnostic value and clinical performance of cardiac ultrasound in patients with chronic heart failure and hypertension. Methods. In this prospective study, between August 2017 and January 2020, 50 patients with chronic heart failure and hypertension were recruited and assigned to the study group and 50 healthy individuals during the same period after physical examinations were included in the control group. Cardiac ultrasound examinations were performed on the participants, and the results were compared and analyzed. Results. The study group had a higher left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), and late diastolic peak flow velocity (A wave) and showed lower early diastolic peak flow velocity (E wave) and late diastolic peak flow velocity/lower early diastolic peak flow velocity (E/A) ratio levels than in the control group. The study group had 15 patients with grade I cardiac function (ultrasound detection rate of 100%), 18 patients with grade II cardiac function (ultrasound detection rate of 100%), and 17 patients with grade III cardiac function (ultrasound detection rate of 100%). Grade I cardiac function patients showed the lowest LVEDD, LVESD, and E/A and the highest LVEF than grade II patients, followed by grade III patients. The study group showed higher LVEF and echocardiographic estimation of the pulmonary arterial systolic pressure (PASP) and lower right ventricular lateral wall systolic excursion velocity and tricuspid annular plane systolic excursion (TAPSE) than the control group. Chronic heart failure with hypertension was associated with high levels of right atrial total emptying volume (RAVIt), right atrial passive emptying volume (RAVIp), right atrial active emptying volume (RAVIa), and right atrial active emptying fraction (RAVIaEF) and low levels of right atrial total emptying fraction (RAVItEF) and right atrial passive emptying fraction (RAVIpEF) versus the healthy status (all P < 0.05). Conclusion. Cardiac ultrasound is a noninvasive operation with low cost, high repeatability, and accurate detection, which can identify right heart function impairment at an early stage, assist clinical treatment, and improve patient prognosis, so it is worthy of promotion and application.
Energy-Efficient UART Design on FPGA Using Dynamic Voltage Scaling for Green Communication in Industrial Sector
Authors: Haripriya D. , Kumar Keshav , Shrivastava Anurag , Al-Khafaji Hamza Mohammed Ridha , Moyal Vishal , Singh Sitesh Kumar
Published: May 2022

In the present scheme of the world, the problem of shortage of power is seen across the world which can be a vulnerability to various communication securities. The scope of proposed research is that it is a step towards completing green communication technology concepts. In order to improve energy efficiency in communication networks, we designed UART using different nanometers of FPGA, which consumes the least amount of energy. This shortage is happening because of expanding of industries across the world and the rapid growth of the population. Therefore, to save the power for our upcoming generation, the globe is moving towards the concept and ideas of green communication and power-/energy-efficient gadget. In this work, a power-efficient universal asynchronous receiver transmitter (UART) is implemented on 28 nm Artix-7 field-programmable gate array (FPGA). The objective of this work is to reduce the power utilization of UART with the FPGA device in industries. To do this, the same authors have used voltage scaling techniques and compared the results with the existing FPGA works.
English Speech Feature Recognition-Based Fuzzy Algorithm and Artificial Intelligent
Authors: Miao Yuji , Liu Haiying , Gu Shan
Published: May 2022

It is necessary to study the application of digital technology in English speech feature recognition. This paper combines the actual needs of English speech feature recognition to improve the digital algorithm. Moreover, this paper combines fuzzy algorithm to analyze English speech features, analyzes the shortcomings of traditional algorithms, proposes the fuzzy digitized English speech recognition algorithm, and builds an English speech feature recognition model on this basis. In addition, this paper conducts time-frequency analysis on chaotic signals and speech signals, eliminates noise in English speech features, improves the recognition effect of English speech features, and builds an English speech feature recognition system based on digital means. Finally, this paper conducts grouping experiments by inputting students’ English pronunciation forms and counts the results of the experiments to test the performance of the system. The research results show that the method proposed in this paper has a certain effect.
Analysis of Supply Chain Optimization Method and Management Intelligent Decision under Green Economy
Authors: Li Minyi , Zhou Yi
Published: May 2022

As environmental issues become the focus of global attention, low-carbon economy based on the concept of low energy consumption, low pollution, and sustainable development is becoming the focus of global attention. This new trend brings new challenges and opportunities to supply chain management. In view of the current new trend, each node enterprise in the supply chain should have the dual compatibility of economy and environment. How to balance the profits of supply chain nodes is an important issue for traditional enterprises under the guarantee of environmental benefits and green supply chain management. This paper takes the green transformation of enterprises as the breakthrough point, combined with the comparison of three green supply chain models. Considering the different preferences of enterprises for environmentally friendly goals, a green supply chain model is constructed when manufacturers and retailers consider different goals. This paper discusses the impact of environmental preferences of manufacturers and retailers on the supply chain system. It is found that when the manufacturer’s environmental preference is 1, the supply chain profit of the biobjective model is up to 1901. The results show that the model can achieve the dual optimization of the profit target and environmental friendly target and achieve the effect of green supply chain optimization.
A Novel Faster RCNN with ODN-Based Rain Removal Technique
Authors: Kollapudi Purnachand , Nair Mydhili K , Parthiban S. , Mardani Abbas , Upadhye Sachin , Nassa Vinaykumar , Abdul-Rasheed Akeji Alhassan Alolo
Published: May 2022

During rainy times, the impact of outdoor vision systems gets considerably decreased owing to the visibility barrier, distortion, and blurring instigated by raindrops. So, it is essential to eradicate it from the rainy images for ensuring the reliability of outdoor vision system. To achieve this, several rain removal studies have been performed in recent days. In this view, this paper presents a new Faster Region Convolutional Neural Network (Faster RCNN) with Optimal Densely Connected Networks (DenseNet)-based rain removal technique called FRCNN-ODN. The presented involves weighted mean filtering (WMF) is applied as a denoising technique, which helps to boost the quality of the input image. In addition, Faster RCNN technique is used for rain detection that comprises region proposal network (RPN) and Fast RCNN model. The RPN generates high quality region proposals that are exploited by the Faster RCNN to detect rain drops. Also, the DenseNet model is utilized as a baseline network to generate the feature map. Moreover, sparrow search optimization algorithm (SSOA) is applied to choose the hyperparameters of the DenseNet model namely learning rate, batch size, momentum, and weight decay. An extensive experimental validation process is performed to highlight the effectual outcome of the FRCNN-ODN model and investigated the results with respect to several dimensions. The FRCNN-ODN method produced a higher UIQI of 0.981 for the applied image 1. Furthermore, on the applied image 2, the FRCNN-ODN model achieved a maximum UIQI of 0.982. Furthermore, the FRCNN-ODN algorithm produced a higher UIQI of 0.998 on the applied image 3. The simulation outcome showcased the superior outcome of the FRCNN-ODN (Optimal Densely Connected Networks) model with existing methods in terms of distinct measures.
Diagnosis and Management of Atypical Chronic Myeloid Leukemia with a t(2;13)(q33;q12) Translocation
Authors: Wang John S. , Elghawy Omar , Kurpiel Brett R. , Douvas Michael G.
Published: May 2022

Atypical chronic myeloid leukemia (aCML) is a rare myeloproliferative disorder that shares clinical features with chronic myeloid leukemia but lacks the classic t(9;22) BCR-ABL1 translocation and features prominent dysgranulopoiesis and granulocytic dysplasia. Challenges of this diagnosis include clinical and biologic heterogeneity, the high risk of transformation to acute myeloid leukemia, and the lack of standard treatment options. Allogeneic hematopoietic stem cell transplant is likely the preferred treatment, but this can be limited by patient psychosocial support, age, concomitant medical conditions, and availability of an appropriate donor. We report the case of a 61-year-old male with no significant past medical history diagnosed with aCML with a rare t(2;13)(q33;q12). He presented with weight loss, night sweats, splenomegaly, hyperleukocytosis, a leukoerythroblastic differential with a predominant neutrophilia, anemia, and thrombocytopenia. Subsequent peripheral blood and bone marrow studies lead to the diagnosis of aCML. He was recommended to undergo an allogeneic stem cell transplant evaluation and declined. He was initially treated with hydroxyurea and imatinib to which he responded for approximately three years. After clinical progression, he was treated with sorafenib, a multiprotein kinase inhibitor more commonly used in the treatment of hepatocellular and renal cell carcinoma due to its off target FLT3 inhibition. The patient achieved complete hematologic response which has been sustained for 7 years with tolerable side effects.
Optimal Design of Periodic Honeycomb Plate with Unit Cell Structure Based on Genetic Algorithm
Authors: Feng Yanbo , Sun Xinzu , Chen Bo , Ni Haiyue
Published: May 2022

Composite honeycomb sandwich plates have been widely used in aerospace, ships, construction bridges, machinery, stationery, and other industries. In order to improve the performance and configuration, taking the structural dynamic characteristics of periodic honeycomb plate as the research object, a structural optimization design method based on natural frequency and stiffness was proposed with the goal of weight reduction. The geometric parameters of the structure system were trained by the multiobjective optimization genetic algorithm (MOGA), and the Pareto optimal solution of variable combination was obtained. This paper presented a decoupling method for complex system optimization design based on dynamic performance from the perspective of basic unit, which could solve the coordination problem of vibration stability and weight reduction in periodic honeycomb plate structure optimization design. It has reference significance for the similar composite material frame base structure design.
Cultivation of Different Oyster Mushroom (Pleurotus species) on Coffee Waste and Determination of Their Relative Biological Efficiency and Pectinase Enzyme Production, Ethiopia
Authors: Dissasa Guta
Published: May 2022

Cultivation of specialty mushrooms on lignocellulosic wastes represents one of the most economic and cost-effective organic recycling processes. Solid-state cultivation (SSC) was carried out to evaluate the feasibility of using coffee waste (husk and parchment) as substrate for cultivation of oyster mushroom (Pleurotus species). The periods for spawn running, pinhead and fruit body formation, number of flushes, yield, and biological efficiency of the four Pleurotus species (P. citrinopileatus, P. eryngii, P. ostreatus, and P. sapidus) grown on coffee husk and parchment were studied. The results revealed that the time for the first appearance of pinhead was shortest for P. ostreatus (20–21) days followed by P. sapidus (22–23) days on coffee husks, while P. eryngii and P. citrinopileatus required 26–27 days and 23–24 days, respectively, on the some substrate. All the four Pleurotus species recorded at least four flushes and three flushes on coffee husk and parchment, respectively; flush 1 gave the highest yield while flush 3 and 4 gave the lowest yield. The biological efficiency (B.E.) for P. citrinopileatus, P. eryngii, P. ostreatus and P. sapidus obtained from fresh coffee husk was 26.54, 40.94, 60.33, and 55.72, respectively. Significant differences (

P
<
0.05

) in yield and % B.E. of the four mushrooms species were recorded. The results also showed that the B.E. (61.92%) of P. ostreatus grown on composted coffee husk was insignificantly higher (

P
<
0.05

) than that grown on noncomposted coffee husk (60.33). The yields of P. sapidus obtained from the two substrates were almost comparable with that of P. ostreatus. There was a significant difference at (

P
<
0.05

) observed between noncomposted and composted coffee husk and coffee parchment as well as between coffee husk and coffee parchment on yield and biological efficiency (B.E.). Composted coffee waste is more efficient than noncomposted one. Pectinase enzymes productions by these mushrooms were also studied. They are known to produce extracellular enzymes, particularly pectinase, which contribute to the biochemical decomposition of pectin-rich lignocellulosic wastes biomass. Accordingly, P. sapidus showed more pectolytic activities followed by P. ostreatus. But the pectolytic activity showed by P. eryngii and P. citrinopileatus was relatively lower. The implications of this study are the feasibility of using composted coffee husks and coffee parchment with the supplementary substrate to cultivate very protein-rich mushrooms for food in solid-state cultivation (SSC) while at the same time promoting environmental sustainability.
Darcy‐Forchheimer 3D Flow of Glycerin‐Based Carbon Nanotubes on a Riga Plate with Nonlinear Thermal Radiation and Cattaneo‐Christov Heat Flux
Authors: Eswaramoorthi S. , Loganathan K. , Jain Reema , Gyeltshen Sonam
Published: May 2022

The current investigation deliberates the consequence of the glycerin‐based carbon nanotubes with velocity slip in Darcy‐Forchheimer porous medium on a convectively heated Riga plate. The Fourier heat flux theory was replaced by the Cattaneo‐Christov theory. Moreover, nonlinear facets of radiation are also included in the energy expression, and this creates the energy expression which becomes highly nonlinear. The governing flow problems are altered into an ODE model with the help of suitable variables. The reduced models are solved numerically by applying MATLAB bvp4c theory and analytically by HAM idea. The impact of diverse physical parameters on velocity, temperature, skin friction coefficients, local Nusselt number, entropy generation, and Bejan number are scrutinized through tables and graphs. It is seen that both directions of fluid motion elevate when raising the modified Hartmann number, and it diminishes when escalating the quantity of the Forchheimer number and porosity parameter. The fluid warmth grows when the higher magnitude of the Biot number and heat generation/consumption parameter, and it downturns when enriching the thermal relaxation time parameter. The entropy generation slumps when heightening the slip parameter, whereas it improves when rising the radiation parameter. The Bejan number upturns when upgrading the Biot number and heat generation/consumption parameter.
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson’s Disease
Authors: Huang Zifeng , Han Jiajun , Wu Peipei , Wu Chunxiao , Fan Yaohua , Zhao Lijun , Hao Xiaoqian , Chen Dongfeng , Zhu Meiling
Published: May 2022

Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, which is related to brain iron metabolism disorders. Ferroptosis is a newly discovered iron-dependent programmed cell death mode, which has been considered an essential mechanism of PD pathogenesis in recent years. However, its underlying mechanisms have not been fully understood. In the present study, the PD rat model and PD cell model were induced by 6-hydroyxdopamine (6-OHDA). The results showed that the expression of Sorting Nexin 5 (SNX5) and the level of ferroptosis will increase after treatment with 6-OHDA. Consistent with these results, ferroptosis inducer erastin synergistically reduced the expression of glutathione peroxidase 4 (GPX4) and increased the expression of SNX5 in the PD cell model, while ferroptosis inhibitor ferrostatin-1 (Fer-1) inhibited the decrease of GPX4 and the increase of SNX5 in the PD cell model. Knockdown of SNX5 in PC-12 cells could reduce intracellular lipid peroxidation and accumulation of Fe2+ and significantly inhibit the occurrence of ferroptosis. In conclusion, the present study suggested that SNX5 promotes ferroptosis in the PD model, thus providing new insights and potential for research on the pharmacological targets of PD.
Analysis on the Evolution Mechanism of Open Environmental Protection Innovation among Equipment Manufacturing Oligopolistic Enterprises Based on Data Simulation
Authors: Wang Yang , Fu Liyou
Published: May 2022

The global economic environment is becoming increasingly complex with the variable change in the competition regulation and the merging of technological innovation. A single equipment manufacturing enterprise cannot achieve the realization of an intelligent strategy. With the help of open innovation, the enterprise can build an intelligent manufacturing innovation ecosystem based on promoting internal re-engineering of enterprises and mutual opening of internal innovation resource processes among enterprises to strengthen cooperation. However, since open innovation is a complex collaborative innovation of multiorganizational cooperation, this paper analyzes and discusses the green open innovation cooperation strategy among oligopolistic enterprises in the equipment manufacturing industry under the influence of environmental regulation by using relevant models and theories of evolutionary game theory. In addition, the optimal combination under the existing situation is selected by using the model to simulate and analyze the selection trends and results of oligopolistic enterprises several times. The study shows that the probability of choosing an open green innovation strategy among oligopolistic equipment manufacturing firms is positively proportional to the excess benefit of open green innovation and government subsidies and inversely proportional to the excess benefit of knowledge spillover, government penalties, and the cost of open collaborative innovation and knowledge spillover between two firms.
ROS-Responsive miR-150-5p Downregulation Contributes to Cigarette Smoke-Induced COPD via Targeting IRE1α
Authors: Zhu Mengchan , Ye Ling , Zhu Guiping , Zeng Yingying , Yang Chengyu , Cai Hui , Mo Yuqing , Song Xixi , Gao Xin , Peng Wenjun , Wang Jian , Jin Meiling
Published: May 2022

MicroRNAs (miRNAs) have been reported in human diseases, in which chronic obstructive pulmonary disease (COPD) is included. Herein, we assessed the role along with the possible mechanisms of miR-150-5p in cigarette smoke- (CS-) induced COPD. The plasma miR-150-5p expression was lower in patients with COPD and acute exacerbation of COPD (AECOPD) and was related to disease diagnosis, disease severity, and lung function. Consistently, exposure to CS for 3 months or 3 days reduced miR-150-5p in the plasma and lung tissues of mice, and CS extract (CSE) inhibited miR-150-5p in human bronchial epithelial cells (HBECs) in a concentration along with time-dependent approach. In vitro, miR-150-5p overexpression decreased the contents of inflammatory factors interleukin- (IL-) 6, IL-8 along with cyclooxygenase-2 (COX-2), and endoplasmic reticulum (ER) stress markers glucose-regulated protein (GRP) 78 and C/-EBP homologous protein (CHOP) and promoted cell migrate. Mechanistically, miR-150-5p could bind with the 3

′

-untranslated region (UTR) of inositol requiring enzyme 1α (IRE1α), while IRE1α overexpression obliterated the impacts of miR-150-5p. Besides, N-acetyl-cysteine (NAC) reversed CSE-induced miR-150-5p downregulation and its downstream effects. In vivo, miR-150-5p overexpression counteracted CS-triggered IRE1α upregulation, inflammation, and ER stress in the lung tissues of mice. In conclusion, our findings illustrated that ROS-mediated downregulation of miR-150-5p led to CS-induced COPD by inhibiting IRE1α expression, suggesting to serve as a useful biomarker for diagnosing and treating COPD.
Health Promotion Effects of Sports Training Based on HMM Theory and Big Data
Authors: Song Haiyan , Ma Yao , Chen Hongwei
Published: May 2022

In order to better analyze human health status and guide people to carry out reasonable physical training, this paper puts forward the construction method of human health status evaluation model after sports training based on big data. Firstly, the characteristic information of human health status after sports training is collected based on big data technology, and the evaluation index and evaluation algorithm of human health status after sports training are constructed. The evaluation system of human health status after sports training is constructed. Finally, the experiment proves that the proposed evaluation model of human health status after sports training based on big data has high practicability in the process of practical application and fully meets the research requirements.
CAPRIN1 Enhances Chemoresistance and Glycolysis in Laryngeal Squamous Cell Carcinoma via Regulation of ZIC5
Authors: Zhang Yubo , Zhang Haizhong , Dong Jinhui , Zhao Pengxin , Hao Fang , Han Haixia , Bian Yanrui
Published: May 2022

Background. Cytoplasmic activation/proliferation-associated protein-1 (CAPRIN1) plays an important role in carcinogenesis, whereas its role in laryngeal squamous cell carcinoma remains unclear. This study was designed to investigate the roles of CAPRIN1 in glycolysis and chemoresistance and its underlying mechanisms in laryngeal squamous cell carcinoma. Methods. Cell viability was evaluated by using CCK-8 and colony formation assays. qRT-PCR, Western blotting, and immunohistochemistry were used to determine the expressions of target genes. Gene knockdown and overexpression cell lines were constructed by performing transfection of siRNAs and plasmids, respectively. Luciferase reporter assay, RNA pull-down, and RNA immunoprecipitation assays were applied to evaluate the RNA-protein interactions. The Kaplan–Meier analysis was performed to evaluate the relationship between gene expression and overall survival rate. Results. An elevation of CAPRIN1 was identified to be associated with chemoresistance and poor prognosis in patients with laryngeal cancer. The increase of CAPRIN1 promoted glycolysis and chemoresistance, whereas the knockdown of CAPRIN1 inhibited glycolysis and chemoresistance in laryngeal cancer cells. The underlying mechanistic investigation revealed that CAPRIN1 promoted glycolysis and chemoresistance of laryngeal cancer cells by the regulation of Zic Family Member 5 (ZIC5). Conclusion. CAPRIN1 promoted laryngeal squamous cell carcinoma glycolysis and chemoresistance by the regulation of ZIC5.
Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7
Authors: Yuan Daiyue , Chen Jie , Hao Qingya , Zhang Peng , Chen Zhong
Published: May 2022

We aimed to investigate the role of methyltransferase-like 3 (METTL3) in regulating HCC by mediating m6A level of ubiquitin-specific protease (USP7). METTL3 levels and m6A contents in HCC tissues and cells were detected. Potential correlations between METTL3 level and lymphatic metastasis, tumor size, tumor staging, and overall survival of HCC patients were analyzed. Moreover, its regulatory effects on proliferative, migratory, and invasive rates of HCC cells were examined. Potential methylation of USP7 in HCC was predicted using an online software, and the correlation between USP7 and METTL3 was assessed. METTL3 and m6A were increased both in HCC cells and tissues. High level of METTL3 was associated with the incidence of lymphatic metastasis, large tumor size, advanced tumor staging, and low overall survival of HCC. Silencing of METTL3 reduced proliferation, migration, and invasion rates. USP7 was predicted to have a methylation site regulated by METTL3. It was upregulated in HCC and associated with METTL3 level positively. USP7 silencing decreased proliferation, migration, and invasion rates of HCC cells. METTL3 promotes HCC to proliferate, migrate, and invade by regulating m6A methylation of USP7.
Catastrophic Antiphospholipid Syndrome after Orthotopic Liver Transplant
Authors: Okeke R. , Lok J. , Wells R. , Wycoff M. , Engelhardt A. , Bettag J. , O’Leary C. , Hallcox T. , Nazzal M.
Published: May 2022

Background. Catastrophic antiphospholipid syndrome (CAPS) is an autoimmune thrombogenic disorder of small and large vessels caused by autoantibodies against phospholipids and phospholipid-binding proteins. This severe form of antiphospholipid syndrome (APS) presents clinically with simultaneous life-threatening multiorgan thrombosis and the presence of two or more persistent antiphospholipid antibodies (APL) confirmed on testing 12 weeks apart. Case Presentation. We describe a case report of a 66-year-old woman with detected antinuclear antibodies (ANA) pretransplant diagnosed with CAPS following orthotopic liver transplant. The patient had acute respiratory failure; Doppler ultrasound and CT angiogram confirmed thrombosis in the hepatic artery, subsequent occlusion of the jump graft, and a splenic infarct. Hypercoagulability workup showed elevated levels of anticardiolipin IgG and beta-2-glycoprotein IgG/IgM and positive lupus anticoagulant, treated with steroids and anticoagulation. The patient was discharged after one month and was transitioned from heparin to life-long warfarin. Conclusion. Our patient provided a standard presentation of CAPS with abnormal pretransplant levels of antinuclear antibodies (ANA). Although there have been studies investigating the relationship between anticardiolipin antibodies and lupus anticoagulants and APS, the relationship between pretransplant positive ANA or antimitochondrial antibodies (AMA) and CAPS has yet to be explored. Further studies will be needed to determine the significance of these antibodies. We recommend preoperative APL testing for patients with positive ANA and AMA at preliver transplant presentation.