bluuebunny/crossref_metadata_2025 huggingface dataset:
SOCS3 expression in cutaneous lichen planus
Authors: Doss Reham William , El-Rifaie Abdel-Aziz , Rashed Laila Ahmed , Naguib Rehab
Published: April 2023

Background: Lichen Planus (LP) is an idiopathic, inflammatory, autoimmune disease. The aetiopathogenesis of LP is still unclear. Suppressor of cytokine signaling- 3 (SOCS3) is known to inhibit cytokine signaling through Janus kinase (JAK) /signal transducers, activators of transcription , NFkB, and focal adhesion kinase (FAK) signaling pathways. Modulation of SOCS3 level leads to immune dysfunction.
Aim of the work: Our study aimed to detect a possible role of SOCS3 in cutaneous LP
Methods: In this case - control study skin biopsies were collected from 30 LP patients and 30 healthy volunteers. Biopsies were kept in lysis solution frozen at -80 Celsius till analysis of SOCS3 using Real time polymerase chain technique (RT-PCR) was done.
Results: The expression of SOCS3 in cutaneous LP was significantly higher when compared to normal skin from healthy controls (p < 0.001).
Conclusion: SOCS3 might play a role in the pathogenesis of LP
Exploring the National Nursing Research Priorities in the Eastern Mediterranean Region and Overcoming Associated Challenges
Authors: Nashwan Abdulqadir J. , Hashish Ebtsam A. Abou , Mohamed Ahmed S. , Alrimawi Intima , Aqtam Ibrahim , Obeisat Salwa Al , Alhalaiqa Fadwa , Alzaatreh Mohammad , Alhadidi Majdi , AL-Fayyadh Sadeq , Faleh Jadeel N. , Shaban Marwa M. , Shaban Mostafa , Mirzaei Alireza , Vakilabad Reza N. , Arabloo Jalal , Siddique Sulman , Alharbi Hanan F. , Alshdefat Aisha , Atout Maha
Published: April 2023

Background Nurses play a significant role in contributing to various health priorities globally, including research. Identifying the status of national nursing research priorities (NNRPs) in the Eastern Mediterranean Region (EMR) is crucial to cultivate these priorities. Aim This paper aims to highlight the existing status of NNRPs in EMR countries concerning their existence and publicity. Methods Experts from nine EMR countries, including Egypt, Iran, Iraq, Jordan, Pakistan, Palestine, Qatar, Oman, and Saudi Arabia, responded, and participated in this report. The analysis was conducted to determine the percentage of countries with existing, under development, or nonexistent NNRPs. Results The analysis shows that 58% of the participating countries have existing NNRPs, while 25.8% don't and 16% are under development. The largest portion of NNRPs (38%) was developed by governmental organizations. Midwives were not specified in half of the published priorities. The majority of NNRPs (65%) were developed by experts’ opinions and consensus, and 33% only have an associated strategy, outcome measures, and funding opportunities. Yet, most of the published research priorities were not updated regularly. Conclusion EMR countries face a challenge with the need for more nurses, which may hinder their involvement in research projects or continued education. Despite this, all countries involved in this report emphasized the importance of developing nursing education and research as priorities for improving their current nursing workforce. Health policymakers, nurse practitioners, academic researchers, educators, and nursing leaders should collaborate to develop operational plans to foster national nursing education and research.
Risk factors associated with the initial unplanned removal of orogastric tubes in NICU: A Single Center Study in China
Authors: Chen Jun , Fang Xiaoling , Dai Yiheng , Liu Lijun , Huang Chaomei
Published: April 2023

Background: Newborns, in particular, are at higher risk for unplanned removal of orogastric tubes (UROGTs). Because there is a lack of studies identifying the incidence and risk factors for UROGTs in China, we designed this case‒control study to investigate them.
Method: This study was conducted in China. A total of 111 neonates who received orogastric tubes between October 2022 and February 2023 were analyzed. Univariate and multivariate logistic models were used for risk factor analyses.
Results: The rate of UROGTs was 56.8%, and the incidence was 7.2 per 100 tube days. An increased risk of UROGTs was associated with higher agitation scores (OR=17.82, P=0.001), no oral feeding (OR=0.02, P=0.007), fixation tape loosening (OR=22.75, P=0.027) and tape wetting (OR=12.6, P=0.021).
Conclusions: The incidence of UROGTs was found to be significantly higher than that of endotracheal tube extubation. The risk factors were higher agitation scores, no oral feeding, fixation tape loosening and tape wetting.
Analysis of rare Parkinson’s disease variants in millions of people
Authors: Pitz Vanessa , Makarious Mary , Bandrés-Ciga Sara , Iwaki Hirotaka , Singleton Andrew , Nalls Mike , Heilbron Karl , Blauwendraat Cornelis
Published: April 2023

Objective
Although many rare variants have been reportedly associated with Parkinson’s disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants.
Methods
We assessed a total of 27,590 PD cases, 6,701 PD proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, and AMP-PD. Based on well-known PD genes, 834 variants of interest were selected from the ClinVar annotated 23andMe dataset. We performed a meta-analysis using summary statistics of all three studies.
Results
The meta-analysis resulted in 11 significant variants after Bonferroni correction, including variants in GBA1 and LRRK2. At least 9 previously reported pathogenic or risk variants for PD did not pass Bonferroni correction in this analysis.
Conclusions
Here, we provide the largest rare variant meta-analysis to date, providing thorough information of variants confirmed, newly identified, or rebutted for their association with PD.
Biologics for asthma have risk of anaphylactic reactions and serious? : A pharmacovigilance study based on a global real-world database
Authors: Park Sunny , Kim Yeju , Lee Geon Ho , Choi Soo An
Published: April 2023

Asthma is a chronic inflammatory condition that affects the lung airways. Chronic use of oral glucocorticoids in patients with severe asthma is associated with several adverse events (AEs). Biologics (omalizumab, benralizumab, mepolizumab, reslizumab, and dupilumab) have been developed as alternative therapies for the treatment of asthma. The aim of this study was to evaluate the risk of anaphylactic reactions associated with these five biologics based on a large global database. We utilized individual case reports from the Uppsala Monitoring Center from 1968 to December 29, 2019. A disproportionality analysis of all drugs and monoclonal antibodies. Anaphylactic reactions were defined according to the "anaphylactic reaction” of the standardized MedDRA queries. Contrary to dupilumab, omalizumab, benralizumab, and mepolizumab demonstrated positive signals related to anaphylactic reactions among all drugs and monoclonal antibodies. Reslizumab, which represented only 315 cases of all AEs, required more reports to determine its association with anaphylactic reactions. This was an important study since the majority (96.2%) of the cases of anaphylactic reactions were reported serious. In conclusion, the results indicate that omalizumab, benralizumab, and mepolizumab are associated with a high risk of anaphylactic reactions, and careful monitoring in the post-injection period is recommended.
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp → π*Ar interaction
Authors: Wehn Paul M. , Yang Song , Grina Jonas A. , Rizzi James P. , Schlachter Stephen T. , Wang Bin , Xu Rui , Yang Hanbiao , Du Xinlin , Han Guangzhou , Wang Keshi , Czerwinski Robert M. , Ged Emily L. , Huang Heli , Halfmann Megan M. , Maddie Melissa A. , Morton Emily R. , Olive Sarah R. , Tan Huiling , Xie Shanhai , Josey John A. , Wallace Eli M.
Published: April 2023

Pharmacokinetic properties of our first-generation HIF-2α antagonist PT2385, including modest solubility, resulted in a high recommended phase 2 dose (RP2D) of 800 mg BID and motivated the pursuit of novel scaffolds which could improve solubility and formulation parameters with the goal of improved pharmacokinetics. Herein we disclose our successful efforts to identify such HIF-2α antagonists through an optimization strategy characterized by: (1) increasing the fraction of sp3 hybridized carbons (Fsp3), (2) replacing the aromatic portion of the indane core with pyridine heterocycles, and (3) improving a putative Olp → π*Ar interaction, an underutilized electrostatic contact in medicinal chemistry. These efforts emphasize the importance of employing multiple strategies in parameter optimization. In isolation, modifications to areas (1) and (2) improved solubility, but with the compromise of reduced potency. In area (3), understanding the importance of an Olp → π*Ar interaction, as documented through a wealth of crystal structures and retrospective calculations, proved essential in guiding SAR and identifying the trifluoromethyl group as a suitable replacement of the sulfone. Only by combining these three strategies could inhibitors with substantially improved solubility and comparable potency be discovered. Finally, the overall improvement in pharmacokinetic properties of the newly identified inhibitors is highlighted through a battery of ADME and in vivo data, including use of pharmacodynamic biomarkers indicative of HIF-2α antagonism.
Urinary retention after gynecologic surgeries for benign diseases in Egyptian women
Authors: Elsaid Mahmoud Atef , Gabriel Mohamed Mohamed Ibrahim , Abdelmoaty Muhamed Ahmed , Elsalhy Mohamed Abd-elrahim
Published: April 2023

Background: Postoperative urinary retention (POUR) is the inability to void following surgery. It is a common complication of gynecologic surgery, particularly when urine incontinence and pelvic organ prolapse are treated.
Objective: To determine the incidence and factors influencing urinary retention following benign gynecologic surgery in Egyptian women.
Patients and methods: This research was done on a total of 100 patients who all had gynecologic surgeries for benign diseases within the period from November 2021 to November 2022 in Al-Hussein University Hospital.
Results: the void volume was significantly lower 24 hours postoperative than preoperative and one-week postoperative (P <0.001). The post-void residuals volume was significantly higher 24 hours postoperative than preoperative and one-week postoperative (P < 0.001). 13 of the 100 women included in the study had retention. There were statistically non-significant differences between the presence of POUR and demographic data (P > 0.05). There were statistical significance differences in both POUR and CS presence (P = 0.045) and need for indwelling catheter (P < 0.001). The void volume was considerably lesser before 24 hours postoperative in the patients with retention than the patients without retention (P < 0.001). The post-void residuals substantially greater 24 hours postoperative in the patients with retention than the patients without retention (P < 0.001).
Conclusion: The findings of this study suggest that benign gynecologic surgery may have an unanticipated impact on postoperative voiding dysfunction.
Optimal degrees of freedom of the lower extremities for human walking and running
Authors: Kudo Shoma , Fujimoto Masahiro , Sato Takahiko , Nagano Akinori
Published: April 2023

Determining the degrees of freedom (DOF) of the linked rigid-body model, representing a multi-body motion of the human lower extremity, is one of the most important procedures in locomotion analysis. However, a trade-off exists between the quality of data fitting and the generalizability of the model. This study aimed to determine the optimal DOF of the model for the lower extremities that balance the goodness-of-fit and generalizability of the model during walking and running using Akaike’s information criterion (AIC). Empirically obtained kinematic data for the lower extremities during walking and running were fitted by models with 9, 18, or 22 DOF. The relative quality of these models was assessed using their bias-corrected AIC (cAIC) value. A significant simple main effect of the model was found on the cAIC value for both walking and running conditions. Pairwise comparisons revealed that the cAIC value of the 18-DOF model was significantly smaller than that of the 9-DOF (walking: p< 0.001, running: p = 0.010) and 22-DOF (walking: p < 0.001, running: p < 0.001) models. These findings suggest that the 18-DOF model is optimal for representing the lower extremities during walking and running, in terms of goodness-of-fit and generalizability.
Diagnostic significance and utility of circulating redox biomarkers in patients with gastric cancer
Authors: Dorf Justyna , Pryczynicz Anna , Matowicka-Karna Joanna , Kędra Bogusław , Żukowski Piotr , Zalewska Anna , Maciejczyk Mateusz
Published: April 2023

The aim of our study was to evaluate the redox status, antioxidant barrier as well oxidative damages in gastric cancer patients. We are also the first to assess the diagnostic utility of redox parameters in GC patients in respect to histopathological parameters. 50 patients with gastric cancer and 50 healthy controls matched for sex and age were included in the study. Antioxidant barrier, redox status and oxidative damage products were measured in serum/plasma samples using colorimetric or spectrophotometric method. The activity of SOD (p < 0.05) was significantly higher whereas the activity of CAT (p < 0.0001), GPx (p < 0.0001), GR (p < 0.0001) and GSH (p < 0.05) was considerably lower in GC patients compared to the control group. Levels of TOS (p < 0.0001), OSI (p < 0.0001), AOPP (p < 0.0001), IMA (p < 0.01), LOOH (p < 0.0001), 8-Iso-P (p < 0.0001) and DNA/RNA (p < 0.0001) were significantly higher, and the levels of TAC (p < 0.0001) and total thiols (p < 0.0001) were considerably lower in GC patients compared to the healthy control. Some redox parameters are characterised by high AUC value in differentiation GC patients according to histopathological parameters. Gastric cancer is strongly linked to systemic redox imbalance as well as increased oxidative damage to proteins, lipids and DNA. Redox biomarkers can be potential diagnostic indicators of gastric cancer advancement.
Wheat varietal diversity affects arbuscular mycorrhizal symbiosis and soil enzymatic activities in the root zone
Authors: Taschen Elisa , Guillot Esther , Dezette Damien , Abadie Josiane , Arnal Didier , Plassard Claude , Taudière Adrien , Enjalbert Jérôme , Roux Xavier Le , Hinsinger Philippe
Published: April 2023

High-input agriculture has been associated with a drastic reduction of within-field crop genetic diversity, while plant (mostly functional) diversity in natural ecosystems has been shown to promote ecosystem functioning. Increasing intra-specific diversity in agroecosystems is a promising strategy to stabilize crop productivity and promote the associated diversity of fauna and microbiota. We investigated the effect of the within-field diversity of bread wheat varieties on arbuscular mycorrhizal fungi (AMF) and two enzymatic activities involved in organic nitrogen and phosphorus mineralization. A field experiment was designed to test whether the number of mixed wheat varieties in a plot, or their functional diversity (previously assessed), influence the abundance and diversity of AMF and the activity of leucine aminopeptidases and phosphatases in the root zone. The AMF abundance was measured by quantitative polymerase chain reaction, community composition was analyzed by Illumina metabarcoding on two AMF specific markers, and potential microbial activities were quantified by biochemical assays. Wheat traits related to root morphology and susceptibility to fungal diseases previously quantified for each variety were also used. Number of varieties significantly increased AMF abundance in roots, whereas functional cluster number did not, with no impact of root morphology. Functional cluster number influenced AMF diversity, though weakly and not linearly, responding most to binary mixtures. Both wheat variety and functional group number increased the potential leucine amino-peptidase activities in the root zone, while no effect was observed for phosphatase activities. Our results highlight that increasing crop intra-specific diversity triggered changes in key processes involved in nutrient acquisition.
From static state to dynamic simulation: a delivery-path-oriented approach to quantify ecosystem services and its application to ecological management
Authors: Su Dan , Wu Qing , Fang Xiaoqian , Cao Yu , CAO Yu
Published: April 2023

As the researches on Ecosystem Services (ESs) become more systematic and mature, concerns on ESs flow have been raising because of its high value in aid ecological management and improvement of human welfare. Despite that the importance of ESs flow have been emphasized, they are mostly semantic, lacking the empirical operation of ESs quantification. Based on the reality observation and literatures extraction, we think the ESs flow can be assessed from direction characteristics, and three classic ESs, crop provision, water yield, and carbon sequestration were chosen as the cases. Combined with their delivery mediums of road work, river runoff, and atmosphere, they are distinguished and classified as three major flow directions, i.e., specific path, single path, and omni-direction. Moreover, the revised two-step floating catchment area method are employed to quantify the ESs flow size, for which has the basic information of supply-side, demand-side, flow direction and distance. The results show (1) the mismatch between supply and demand varies with different ESs and areas. (2) The characteristics of direction, path, services extent, and delivery size of ESs flows are depicted with their own unique attributes. (3) The final ecological status of different areas is changed by integrating the ESs flow into supply and demand, which shows the necessity of ESs flow consideration rather than just supply-demand pattern. This study complements the researches on ESs, generalizes the approach to quantify ESs flow, provides a comprehensive assessment on supply-demand relationship, and offers more scientific and reasonable references to city planning and ecological strategies.
A High-Gain Dual-Band Shared-Aperture Array Integrating Zero-Order-Resonance Patch and Higher-Order Metasurface Antenna
Authors: Chen Qian , Cheng You-Feng , Shao Chen-Hao , Feng Ju , Liao Cheng , Xiao Ding
Published: April 2023

This letter proposes a high-gain shared-aperture array which integrates the hybrid zeroth-order-resonance (ZOR) patch and the higher-order metasurface antenna (MA). In terms of each array element, four hybrid ZOR patches with shorting pins form a metasurface which is fed by slot coupling. Different from some reported designs which have more high-frequency elements than low-frequency ones, the whole array is composed of 4 × 4 hybrid ZOR patches operating in C band (4.74 ∼ 5.12 GHz) and 2 × 2 MAs working in Ku band (13.0 ∼ 14.0 GHz). Such a layout brings that the designed array has the benefit to reduce Ku-band loss. Measure results validate the dual-band operation and show that the antenna has its peak gains of 12.7 dBi and 17.2 dBi in these two bands, respectively.
Feedback of sports intelligent learning system based on model predictive control and artificial intelligence
Authors: Liu Yunzhao , Liu Li
Published: April 2023

The numerical solution of the sports intelligent learning system has high complexity during operation, which restricts the online application of optimal control. In order to improve the optimization effect of the feedback delay of the sports intelligent learning system, this paper discusses the method of efficiently solving the optimal control problem of the differential-algebraic system from the aspects of improving the efficiency of the integration process and selecting an appropriate constraint processing strategy. Moreover, this paper proposes an efficient calculation method for solving the index-1 DAE optimal control problem under continuous inequality constraints. This method avoids a large number of interior point constraints introduced by discretization of continuous inequality constraints and makes it possible to solve optimal control problems under continuous inequality constraints. In addition, this paper designs a one-step advanced model predictive control algorithm to solve the NLP problem one sampling period in advance, and then correct the solution of the NLP problem through sensitivity analysis. Finally, this paper designs experiments to study the performance of the method proposed in this paper. The research results show that the method constructed in this paper is effective.
Application of Multi-sensor Network and Artificial Intelligence in Health Monitoring of Medical Geriatric Care
Authors: Meng Hua , Han Yi , Zan Zhi
Published: April 2023

The comprehensive use of data from multiple sensors for moving target tracking is a long-term problem in multi-sensor data fusion. In wireless sensor networks, state estimation and fusion are the main research issues in target tracking. Distributed is the essential feature of wireless sensor networks. Therefore, with the development of wireless sensor networks, the problem of distributed state estimation has also attracted the attention of scholars. The intelligent medical diagnosis system is composed of a traditional Chinese medicine diagnosis system, a western medicine diagnosis system, and a medical record database. The TCM diagnostic system and the Western medicine diagnostic system are the main body of the system. The TCM diagnostic system is based on a case-based reasoning model, using human body information collection equipment to simulate the process of TCM diagnostics and realize TCM diagnostic engineering, while the Western medicine diagnostic system is a neural network optimized based on genetic algorithms. Model, obtain the diagnosis and treatment method of the disease from the medical record database of the hospital information system. The basic standards for nursing homes issued by the Ministry of Health have promoted the standardized development of nursing homes. However, since the development of China's elderly care homes is still in its infancy, it makes the service content and functional positioning of elderly care homes, and orderly connection with relevant medical institutions and elderly care institutions, The main body of institutional management and the formulation of supporting policies are still in the exploratory stage. Among the chronically ill population, the proportion of elderly people ranks first. At the same time, due to the particularity of the elderly population, the recovery time is lengthened. Due to various reasons, they cannot get adequate medical services in the hospital. Due to the impact of diseases, the health of the elderly is not optimistic, and even loses their lives. Therefore, the daily immediate monitoring of the elderly is very necessary.
Do cancer centres and palliative care wards routinely measure patients’ quality of life? A cross-sectional survey study
Authors: Miranda Rose , Raemdonck Eveline , Deliens Luc , Kaasa Stein , Zimmermann Camilla , Rodin Gary , Robijn Lenzo , Lundeby Tonje , Houbracken Isabelle , Beernaert Kim
Published: April 2023

Purpose: Routinely assessing quality of life (QoL) of patients with cancer is crucial for improving patient-centred cancer care. However, little is known about whether or how cancer centres assess QoL for clinical practice or for research purposes. Therefore, our study aimed to investigate if QoL data is collected and if so, how and for what purposes.
Method: We conducted a cross-sectional survey study among 32 cancer centres in Europe and Canada. Centre representatives identified the most suitable persons within their cancer ward and/or palliative care ward to complete an online survey. Descriptive statistics were used to summarise the information on QoL assessment and documentation.
Results: There were 20 (62.5%) responding cancer centres. In total, 30 questionnaires were completed, of which 13 were completed for cancer wards and 17 for PC wards. We found that 23.1% and 38.5% of the cancer wards routinely assessed QoL among inpatients and outpatients with cancer, respectively, whereas, in palliative care wards, 53% assessed QoL for outpatients with cancer and 70.6% for the inpatients. Wide variabilities were observed between the cancer centres in how, how often, when and which instruments they used to assess QoL.
Conclusion: A sizable proportion of the cancer wards, especially, and PC wards apparently does not routinely assess patients’ QoL, and we found wide variabilities between the cancer centres in how they do it. To promote routine assessment of patients’ QoL, we proposed several actions, such as addressing barriers to implementing patient-reported outcome measures through innovative e-Health platforms.
An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats
Authors: Beyrami Sona , niri Hasan Hadadzadeh , Golmohammadi heidar , Panahi Mohammad Hossein , Abbaszadeh Hojjat Allah , mahmoudi saeed , Fazlzadeh Mehdi , Gharari Noradin
Published: April 2023

Background: Occupational and environmental exposures to organic solvents and noises in the workplace are major health issues. One of these solvents is toluene, and on top of that noise is an impartible part of any industry. the present study aims to determine the alteration of oxidative stress parameters and the histopathological changes caused by simultaneous exposure to toluene and noise in the brain tissue.
Methods: For this purpose, 32 male Wistar rats were divided into four experimental groups and then were exposed to varying factors for 8 hours a day (8 h/day) for 28 days. These four groups were: 1) The control group, 2) The group exposed to noise (100dB), 3) The group exposed to toluene by inhalation (500 ppm), and 4) The group simultaneously exposed to both of them. In this study, the levels of lipid peroxidation (MDA) and glutathione (GSH) and the histopathological changes of the brain tissue were determined.
Results:The findings suggest that, in the various parts of the temporal brain tissue simultaneously exposed to toluene and noise, the cohesion was more decreased compared to the tissues in other groups. Furthermore, in the group simultaneously exposed to both factors the MDA level increased and the GSH level decreased significantly.
Conclusions: The results indicated the impact of synergistic interaction between noise and toluene on the accumulation of oxidation products, the progressive morphological damages as well as the weakening of the antioxidant defense system in brain tissues of rats and being simultaneously exposed to both factors has a cumulative effect
Post-Malaria Neurological Syndrome (PMNS): a rare case report with brain biopsy findings
Authors: Alawad Mouhammad J , Almayoof Moustafa , bozom Adel Al , Alkhidir Taha , Emam Saeed S , Farfar Khalifa
Published: April 2023

Post-malaria neurological syndrome (PMNS) is a rare, self-limiting condition that presents with a wide range of neurological manifestations after clearance of malarial infection, especially Plasmodium Falciparum, most patients recover without residual deficits. Here we present a case of a 29-year-old, male with a recent history of malaria treated successfully, who presented due to a generalized tonic-clonic seizure, without any other neurological symptoms, the examination and labs were unremarkable, he underwent a computer tomography (CT) scan and Magnetic resonant imaging (MRI) which both showed two areas of vasogenic edema involving the subcortical white matter of left frontal and right posterior parasagittal regions, all autoimmune screens, infection workup from blood and CSF were negative, he underwent a brain biopsy that showed intense perivascular inflammation with neuronal loss and gliosis, findings are nonspecific and can be seen in a variety of condition. The patient’s condition improved, and he was discharged without any complications.
New MCDM Applications using Cubic Bipolar Fuzzy Model in Medical and Engineering
Authors: Farooq Adeel , Nabeel Muhammad , Ali Ghous
Published: April 2023

Nowadays, several fuzzy extensions of ELECTRE (Elimination and Selection Transforming Reality) and TOPSIS (The Order Preference by Similarity to Positive Ideal Solution) methods are emerging as powerful mathematical tools for dealing with uncertainties in different multi-criteria decision-making (MCDM) situations of medical and engineering domains. Since cubic bipolar fuzzy (CBF) set theory is also becoming an effective mathematical tool for such kinds of problems. In this study, we present an improved CBF-TOPSIS method using the concepts of normalized Euclidean distance and revised closeness index because in the existing CBF-TOPSIS method the notions of Euclidean distance and relative closeness index were used to reach the final decision. Then, we rectify the shortcomings of the existing CBF-ELECTRE-I method, that is, there was a problem in the discordance formula. To modify the existing algorithm based on the CBF-ELECTRE-I model, we add a new step to find the exact linear ranking order of alternatives, which is purely based on concordance and discordance outranking coefficients. Second, we explore two new applications to validate the applicability and feasibility of the improved CBF-ELECTRE-I and CBF-TOPSIS methods in medical and engineering. Finally, to demonstrate the veracity of the modified CBF-ELECTRE-I and CBF-TOPSIS methods, we perform a brief sensitivity analysis between them and other existing models.
A method for calculating left ventricular ejection fraction non-invasively from left ventricular arterial coupling (Ees/Ea)
Authors: Yamazaki Yukiko , Matsuki Yuka , Shigemi Kenji
Published: April 2023

Background: Ejection fraction (EF) is a standard method of evaluating of cardiac function.
EF is useful to monitor cardiac function and circular management during general anesthesia, but it is impossible to calculating EF using ultrasonography continuously and non-invasively.
The aim of our study is development of the method to estimate EF non-invasively from left ventricular arterial coupling (Ees/Ea).
Methods: Ees/Ea can be estimated non-invasively from pre-ejection period (PEP), ejection time (ET), end-systolic pressure (Pes) and diastolic pressure (Pad). These parameters were calculated from a vascular screening system, VeSera 1000/1500(Fukuda Denshi Co., Ltd., Tokyo, Japan). The left ventricular efficiency (Eff) as a pump, is defined as the ratio of external work (EW) to myocardial oxygen consumption, as strongly correlated to pressure-volume area (PVA). Eff can be calculated from Ees/Ea, and EF(EFeff) was approximated from Eff. We measured EF using transthoracic echocardiography, and compared it with EFeff.
Results: The study included 44 healthy adults (36 males, 8 femals). EFecho was 66±5 %, EFeff was 57±9 %. There was a positive correlation between EF and EFeff (R2 = 0.219, p < 0.05 ). Result of Bland-Altman analysis, the limits of agreement were – 7.5 to 24.4 %, the PE was 24%.
Conclusion: The results suggest that EF can be measured non-invasively using left ventricular arterial coupling.
QuickAware: A Virtual reality tool for Quick Clay Landslide Hazard Awareness
Authors: Alene Gebray Habtu , Depina Ivan , Thakur Vikas , Perkis Andrew , Bruland Oddbjørn
Published: April 2023

In recent years, the area of application of Virtual Reality (VR) has grown tremendously from the entertainment industry to the military, to mental health, to hazard identification training, and to our daily lives. VR has been widely employed in hazard identification and prevention, safety training, evacuation, search and rescue, and damage identification of hazards. This paper investigates the application of VR for raising awareness about quick clay landslide hazard. Quick clay landslides are geological hazards that are often triggered suddenly, are difficult to forecast, and often result in disastrous consequences. Currently, hazard and risk maps are used to communicate quick clay landslide risk to the public. However, these maps are mostly expert specific, and they may not appear convenient to communicate natural hazards such as quick clay landslides to the public. VR technology can be used to further enhance the communication of landslide risk to the public by developing simulations that can raise awareness about, among others, landslide initiation signs, preventive measures, safety training, and actions that can increase safety of individuals in a hazard event. To narrow this communication gap, we developed a tool, QuickAware, that can help in improving awareness of quick clay risk using a VR application. The development process of the tool started with a co design approach where stakeholder experts were brought to collaborate in setting up VR scenarios and defining the VR environment contents. The contents were then conceptualized and translated into VR experience. The usability of the VR application was examined by conducting a survey with 16 participants. The results of the survey indicated that the tool has a promising value in improving awareness creation for quick clay landslide hazard.
Circuit Change during Extracorporeal Membrane Oxygenation: Single-Center Retrospective Study of 44 Changes
Authors: Genty Thibaut , Burguburu Stanislas , Imbert Audrey , Roman Calypso , Camille Wirth , Thès Jacques , Stéphan François
Published: April 2023

Background: Bleeding and thrombosis induce major morbidity and mortality in patients under extracorporeal membrane oxygenator (ECMO). Circuit changes can be performed for oxygenation membrane thrombosis but are not recommended for bleeding under ECMO. The objective of this study was to evaluate the course of clinical, laboratory, and transfusion parameters before and after ECMO circuit changes warranted by bleeding or thrombosis.
Methods: In this single-center, retrospective, cohort study, clinical parameters (bleeding syndrome, hemostatic procedures, oxygenation parameters, red-cell transfusion) and laboratory parameters (platelet count, hemoglobin, fibrinogen, PaO2) were collected over the seven days surrounding the circuit change.
Results: In the 274 patients on ECMO from January 2017 to August 2020, 44 circuit changes were performed in 40 patients, including 32 for bleeding and 12 for thrombosis. Mortality was similar in the patients with vs. without changes (17/40, 43% vs. 103/234, 44%) and in those with bleeding vs. thrombosis (12/32, 43% vs. 5/12, 42%, P=0.94). In patients with bleeding, numbers of bleeding events, hemostatic procedures, and red-blood-cell transfusions were significantly higher before vs. after the change (P<0.001); the platelet counts and fibrinogen levels decreased progressively before, and increased significantly after, the change. In patients with oxygenator thrombosis, no significant differences were demonstrated between oxygenation parameters (ventilator FiO2, ECMO FiO2, and PaO2) and ECMO flow before vs. after the change.
Conclusions: In patients with bleeding, changing the ECMO circuit decreased clinical bleeding and red-blood-cell transfusion needs and increased platelets and fibrinogen levels. Oxygenation parameters did not change significantly in the group with thrombosis.
In vitro and in vivo evaluation of alginate hydrogel-based wound dressing loaded with green chemistry cerium oxide nanoparticles
Authors: Zhao Ran , Zhao Chenyuyao , Wan Yi , Wang Yibing
Published: April 2023

Interactive wound dressings have shown promising results in promoting the wound healing process. In the present study, we tried to fabricate interactive/bioactive nanocomposite wound dressing with potent antioxidant properties. We fabricated cerium oxide nanoparticles using curcumin as the reducing and capping agent. SEM, EDX, DLS, Zetasizer, FTIR, and XRD were applied to characterize the green-synthesized cerium oxide nanoparticles. The synthesized nanoparticles were incorporated into alginate hydrogel and the microstructure, porosity, and swelling state of the fabricated wound dressing were evaluated. The characterizations revealed the physical and chemical properties of the green-synthesized cerium oxide nanoparticles and the incorporated alginate hydrogel-based wound dressing. The in vitro studies showed that the alginate hydrogel-based wound dressing exhibited acceptable antioxidant activities and were hemocompatible and biocompatible. The animal studies (rat full-thickness skin wound model) showed that the alginate hydrogel-based wound dressing were able to promote the wound healing process. The results indicated that the alginate hydrogel-based wound dressing can be applied as effective wound dressing/healing materials.
Python Java Joint Implementation of Internet based Public Opinion Information Collection
Authors: Liu Hongyan , Liu Zhenyu , Sun Dan , Liu Yandong
Published: April 2023

Nowadays, with the rapid development of the Internet era, the network, as a new media form, has spread rapidly in daily news reports and public opinions, and has also penetrated into today's social life. Compared with real life, people's opinions on the Internet are more active. Major or popular events are often discussed quickly by network users, forming public opinion. Many people want to express their ideas and opinions through the Internet, and some of them will forward and follow up relevant information, but also cause huge public opinion pressure on relevant departments and the speech itself, even to unpredictable results. Therefore, this paper uses Python Java technology to establish a network public opinion information collection system. This system is mainly based on the current popular UML modeling tools, and uses this technology as much as possible in all subsequent descriptions by analyzing some cases and scenarios. The test results show that MySQL's read performance is about 30 times higher than that of Lucene based files when persistence is required and the read performance is guaranteed, which further demonstrates the efficiency of the system. This article has made remarkable achievements in the collection of public opinion and relevant information by constantly optimizing the Python Java technology on the Internet.
Improving the rate of diabetic wound healing using dielectric barrier discharge
Authors: El-Hossary F. M. , Badr Gamal , lashein Fakhr El-din M. , Metawa A.E. , Khalaf Mohamed , Gebril Sahar M.
Published: April 2023

Cold atmospheric plasma (CAP) in the air has been applied to improve the rate of diabetic wound healing in streptozotocin (STZ)-induced diabetic mice. The mice were classified into control, diabetic, and two experimental groups treated with CAP. Wounds were treated with CAP once per day for each experimental group for 10 and 20 sec for 15 consecutive days. The rate of wound healing in the group of diabetic mice that have been treated for 10 sec was higher compared to the group of treated diabetics for 20 sec and the control. Histological analyzes of control and plasma-treated for 10 sec revealed epidermal formation, cell proliferation, and improve inflammation earlier as compared to both the diabetic and the treated diabetic for 20 sec. Concomitantly, recovered cytokines (TNFα, CTGF) were relatively similar to the control during the healing period in 10 sec treated group as compared to the diabetic one. Our study confirmed the efficacy of CAP for medical plasma therapies.
Visualization system of martial arts training action based on artificial intelligence algorithm
Authors: Hui Bowen
Published: April 2023

At present, there are many educational methods in the field of Chinese martial arts education, and various types of teaching institutions such as private martial arts schools, national sports institutes, and general institutions of higher learning have been formed. However, the proportion of such groups who choose to receive professional martial arts education is very small compared to the population development base of China's entire higher martial arts education. The main reason is that martial arts training activities must be standardized and professional, and it is difficult to practice effectively in a home environment. Therefore, this paper develops a visualization system of martial arts training movements based on artificial intelligence system. Firstly, the theoretical basis of skeletal point extraction feature and posture quaternion in martial arts, the visualization of martial arts movements based on expression quaternions and the classification model of martial arts movements based on LSTM are introduced. For the human action visualization part, we use the Ogre rendering engine to display human actions and provide a data interface to control the movement of the virtual 3D human model. Then the paper introduced the visualization system design of martial arts training movements, including: system architecture design, system function analysis, visualization module design. Finally, the system is disassembled through the test environment and evaluation indicators, action recognition effect analysis, and system visualization impact analysis, and the application effect of the system is introduced in detail. I hope it can help more people inherit and develop traditional sports and carry forward the spirit of martial arts. so that Wushu, a national traditional activity, can be better spread and popularized. This paper studies the artificial intelligence algorithm and applies it to the design process of martial arts training action visualization system, thus promoting the development of martial arts teaching.
A Method for Measuring the Non-Smoothness of Time Series Data: Dirichlet Mean Energy Function
Authors: Wang Lianchao , Chen Yijin , Song Wenhui , Xu Hanghang
Published: April 2023

This paper proposes an effective method for measuring the non-smoothness of time series data: Dirichlet mean energy function. The method expresses the time series data as an n-dimensional vector based on its own properties, and then abstracts the time series model as a chain graph model based on directed graph theory. The incidence matrix of the time series data is established based on the constructed chain graph model, and the Dirichlet mean energy function is defined in the form of matrix function. The Dirichlet mean energy function can quantitatively express the non-smoothness of time series data. The contribution of this paper is to proposes an effective mathematical tool for measuring the non-smoothness of time series data based on graph theory and matrix theory. In future work, we will further validate the validity of this tool in more application areas and extend this method to high-dimensional time series data.
Association between intimate partner violence and child nutrition status in Rwanda: Findings from recent Rwanda Demographic and Health Survey 2019/20
Authors: Izabayo Josias , Bahati Claire , Niyonsenga Japhet , Gashugi Yves , Munezero Pascaline , Gitibwa Siméon Sebatukura , Uwambaye Peace , Sezibera Vincent
Published: April 2023

Background Despite significant socio-economic progress and a decade of interventions aimed at improving nutrition, malnutrition remains a significant problem among children under the age of five in Rwanda. While several studies have been conducted to identify important risk factors for malnutrition in Rwanda, none have specifically assessed the association between intimate partner violence (IPV) and child nutritional status. Therefore, this study aimed to examine the association between women's exposure to IPV and the nutritional status of their children in Rwanda.Methods The study analyzed secondary data from the Rwanda Demographic and Health Survey 2019–20 (RDHS 2019/20). Data was gathered on women's emotional, physical, and sexual IPV experiences, as well as demographic and socioeconomic characteristics. Furthermore, their children’s birth outcomes were included as mediating factors. To determine the association between IPV exposure and child nutrition status, we used a series of binary logistic regression models. A total of 2,965 children, ages 6 to 59 months, born to women between the ages of 15 and 49 were studied.Results This study found that approximately 36%, 33.8%, and 14.6% of women in partnerships experienced physical, emotional, and sexual IPV, respectively. The prevalence of stunting among their children was 31.4%, and 7% were underweight. The crude analysis showed that women's experiences of sexual (OR = 1.63, 95%CI = 1.19–2.25) and emotional (OR = 1.29, 95%CI = 1.01–1.65) IPV were associated with an increased likelihood of their children being stunted, while only sexual IPV was associated with underweight (OR = 1.77, 95%CI = 1.05–2.99). Even after controlling for birth outcome variables, the association between sexual IPV, and stunting (OR = 1.55, 95%CI = 1.06–2.28) and underweight (OR = 1.99, 95%CI = 1.13–3.56) remained significant. In the full model, after controlling for sociodemographic factors and birth outcome variables, sexual IPV was found to be associated with an increased risk of child stunting (OR = 1.39, 95%CI = 1.03–2.17) but not significantly associated with underweight.Conclusion Women's experience of intimate partner violence is associated with an increased likelihood of their children's malnutrition status. Therefore, prospective interventions should suppress violence against women to reduce the burden of IPV and childhood malnutrition.
Primary cilium of Prrx1+ cells mediate bone-tendon interface development by regulating cell biology
Authors: Guan Changbiao , Xiao Han , Chen Yang , Wang Linfeng , Jin Yuxin , Zhang Tao , Wu Bing , Lin Ziyang , Lu Hongbin , Sun Deyi , Zhou Yongchun
Published: April 2023

Background
Bone-tendon interface (BTI) is a typical fibrocartilaginous insertion consisting of continuous yet functionally graded structure. However, the underlying mechanism of enthesis formation is poorly understood. It was reported that primary cilia sense changes in the microenvironment of the BTI undergoing mechanical stimulation to regulate repairing. The objective of this study is to investigate how primary cilia mediate the enthesis formation.
Methods
Mice at different ages were used for tracing the spatiotemporal distribution of Prrx1+ cells. Cilium were knocked out at 1, 2, 4, and 6 weeks after birth, and the specimens were harvested at 12 weeks to analyze the effect of cilia deletion on the fate of Prrx1+ cells. Histological analysis and microcomputed tomography were utilized to evaluate the formation of BTI. In vitro, Prrx1+ cells were isolated by cell sorting. The expression level of IFT88 protein was knocked down by shRNA, and it was applied to explore the effect of cilia disruption on the proliferation and differentiation of Prrx1+ cells. NVP-LDE225 was used to diminish the expression levels of the Hedgehog (Hh) signaling pathway, which was performed to understand the effect of Hh signaling pathway on the differentiation capacity of Prrx1+ cells.
Results
Prrx1+ cells participate in the formation of BTI, and in the early postnatal development, Prrx1+ cells are abundant at the BTI. In the late development, Prrx1+ cells gradually decreased in number until disappeared. Locally at the BTI, knockout of cilia may attenuate the chondrogenic differentiation capacity of Prrx1+ cells. Conditional knockout of cilia in the early development is not conducive to BTI formation, and few are in the middle and late stages. In vitro, the knockdown of IFT88 by shRNA could diminish the proliferation and differentiation ability of Prrx1+ cells. At the same time, inhibiting the Hh signaling pathway also diminish the differentiation ability of Prrx1+ cells. The mentioned results suggested that primary cilia may regulate the biological function of Prrx1+ cells via the Hh signaling pathway localized in itself.
Conclusions
Primary cilia mediate the biological function of Prrx1+ cells to modulate further BTI formation via the Hh signaling pathway.