bluuebunny/crossref_metadata_2025 huggingface dataset:
Cloud–Fog Collaborative Computing Based Task Offloading Strategy in Internet of Vehicles
Authors: Zhu Chunhua , Liu Chong , Zhu Hai , Li Jingtao
Published: June 2024

Vehicle terminals in the mobile internet of vehicles are faced with difficulty in the requirements for computation-intensive and delay-sensitive tasks, and vehicle mobility also causes dynamic changes in vehicle-to-vehicle (V2V) communication links, which results in a lower task offloading quality. To solve the above problems, a new task offloading strategy based on cloud–fog collaborative computing is proposed. Firstly, the V2V-assisted task forwarding mechanism is introduced under cloud–fog collaborative computing, and a forwarding vehicles predicting algorithm based on environmental information is designed; then, considering the parallel computing relationship of tasks in each computing node, a task offloading cost model is constructed with the goal of minimizing delay and energy consumption; finally, a multi-strategy improved genetic algorithm (MSI-GA) is proposed to solve the above task offloading optimization problem, which adapts the chaotic sequence to initialize the population, comprehensively considers the influence factors to optimize the adaptive operator, and introduces Gaussian perturbation to enhance the local optimization ability of the algorithm. The simulation experiments show that compared with the existing strategies, the proposed task offloading strategy has the lower task offloading cost for a different number of tasks and fog nodes; additionally, the introduced V2V auxiliary task forwarding mechanism can reduce the forwarding load of fog nodes by cooperative vehicles to forward tasks.
Modeling and Suppression of Conducted Interference in Flyback Power Supplies Based on GaN Devices
Authors: Yan Jichi , Wu Haoyuan , Fu Xueliang , Li Mingtong , Yu Yannan
Published: June 2024

The application of GaN power devices has significantly increased the power density of flyback power supplies but has also caused severe electromagnetic interference (EMI) issues. To address the challenge of conducted interference in flyback power supplies, a comprehensive analysis of the transmission mechanism of conducted common-mode noise is undertaken. This analysis involves simplifying the equivalent model of conducted interference and leveraging the circuit characteristics of conducted noise to propose a solution for attenuating common-mode noise. Considering the constraints of external compensation capacitors, a balanced winding is further introduced to mitigate the impact of noise. To enhance the efficacy of conducted interference suppression, it is suggested to change the winding structure of the transformer and incorporate a shielding winding. This configuration aims to minimize the generation and propagation of common-mode noise within the transformer. Finally, experimental verification is carried out using a 150 W GaN flyback power supply prototype. The experimental results demonstrate that the proposed method effectively suppresses common-mode noise in the circuit.
Domain Decomposition Hybrid Implicit–Explicit Algorithm with Higher-Order Perfectly Matched Layer Formulation for Electrical Performance Evaluation under Low-Pressure Discharge Phenomenon
Authors: Wang Rui , Cui Wanzhao , Zhang Le , Wang Yuming , Wei Huan
Published: June 2024

Low-pressure discharge events have a major impact on a satellite’s electrical performance. Most notably, a number of serious issues arise from the inability to directly modify satellite systems that operate in orbit. Accurate analysis of electrical performance is crucial for mitigating the issues arising from the low-pressure discharge phenomenon. Complex structures, such as intricate features and curved structures, are frequently used in satellite systems’ enormous microwave components. In this case, the finite-difference time-domain (FDTD) approach proposes the hybrid implicit–explicit (HIE) algorithm with a domain decomposition method to effectively simulate complex structures under the low-pressure discharge phenomenon. The bilinear transform method is adjusted in accordance with the implicit equations for the anisotropic magnetized plasma environment caused by the discharge. To end unbounded lattices, a higher-order perfectly matched layer is used at the boundary. An example of a microwave connector structure is used to show how well the algorithm performs electrically. According to the findings, the suggested algorithm behaves in a way that is consistent with both the traditional algorithm and the experiments. Furthermore, the phenomenon of low-pressure discharge has a notable impact on the electrical performance of microwave components.
Light Field Spatial Super-Resolution via View Interaction and the Fusing of Hierarchical Features
Authors: Wei Wei , Zhang Qian , Meng Chunli , Wang Bin , Fang Yun , Yan Tao
Published: June 2024

Light field (LF) cameras can capture the intensity and angle information of any scene in one single shot, and are widely used in virtual reality, refocusing, de-occlusion, depth estimation, etc. However, the fundamental limitation between angular and spatial resolution leads to low spatial resolution of LF images, which limits their development prospects in various fields. In this paper, we propose a new super-resolution network based on view interaction and hierarchical feature fusion to effectively improve LF image spatial resolution and preserve the consistency of the reconstructed LF structure. Initially, we provide novel view interaction blocks to represent the relationship between all views, and efficiently combine hierarchical features using a feature fusion block consisting of residual dense blocks (RDBs) to more effectively preserve the parallax structure. In addition, in the process of extracting features, we introduce residual channel-reconstruction blocks (RCBs) to minimize the duplication of channels in the features. An inter-view unit (InterU) and an intra-view unit (IntraU) are employed to minimize redundancy in the spatial domain as well. Our suggested method is tested using public LF datasets, which include large-disparity LF images. The experimental results demonstrate that our method exhibits the best performance in terms of both quantitative and qualitative results.
Raman-Activated Cell Ejection for Validating the Reliability of the Raman Fingerprint Database of Foodborne Pathogens
Authors: Yan Shuaishuai , Guo Xinru , Zong Zheng , Li Yang , Li Guoliang , Xu Jianguo , Jin Chengni , Liu Qing
Published: June 2024

Raman spectroscopy for rapid identification of foodborne pathogens based on phenotype has attracted increasing attention, and the reliability of the Raman fingerprint database through genotypic determination is crucial. In the research, the classification model of four foodborne pathogens was established based on t-distributed stochastic neighbor embedding (t-SNE) and support vector machine (SVM); the recognition accuracy was 97.04%. The target bacteria named by the model were ejected through Raman-activated cell ejection (RACE), and then single-cell genomic DNA was amplified for species analysis. The accuracy of correct matches between the predicted phenotype and the actual genotype of the target cells was at least 83.3%. Furthermore, all anticipant sequencing results brought into correspondence with the species were predicted through the model. In sum, the Raman fingerprint database based on Raman spectroscopy combined with machine learning was reliable and promising in the field of rapid detection of foodborne pathogens.
Osmanthus fragrans Flavonoid Extract Inhibits Adipogenesis and Induces Beiging in 3T3-L1 Adipocytes
Authors: Yang Zhiying , Lu Yuxin , Li Tingting , Zhou Xunyong , Yang Jia , Yang Shuwen , Bu Su , Duan Yifan
Published: June 2024

Osmanthus fragrans has a long history of cultivation in Asia and is widely used in food production for its unique aroma, which has important cultural and economic values. It is rich in flavonoids with diverse pharmacological properties, such as antioxidant, anti-tumor, and anti-lipid activities. However, little is known regarding the effects of Osmanthus fragrans flavonoid extract (OFFE) on adipogenesis and pre-adipocyte transdifferentiation. Herein, this research aimed to investigate the effect of OFFE on the differentiation, adipogenesis, and beiging of 3T3-L1 adipocytes and to elucidate the underlying mechanism. Results showed that OFFE inhibited adipogenesis, reduced intracellular reactive oxygen species levels in mature adipocytes, and promoted mitochondrial biogenesis as well as beiging/browning in 3T3-L1 adipocytes. This effect was accompanied by increased mRNA and protein levels of the brown adipose-specific marker gene Pgc-1a, and the upregulation of the expression of UCP1, Cox7A1, and Cox8B. Moreover, the research observed a dose-dependent reduction in the mRNA expression of adipogenic genes (C/EBPα, GLUT-4, SREBP-1C, and FASN) with increasing concentrations of OFFE. Additionally, OFFE activated the AMPK signaling pathway to inhibit adipogenesis. These findings elucidate that OFFE has an inhibitory effect on adipogenesis and promotes browning in 3T3-L1 adipocytes, which lays the foundation for further investigation of the lipid-lowering mechanism of OFFE in vivo in the future.
Nanocomposite Films of Babassu Coconut Mesocarp and Green ZnO Nanoparticles for Application in Antimicrobial Food Packaging
Authors: Mirres Ana Carolina de Morais , Vieira Italo Rennan Sousa , Tessaro Leticia , da Silva Bruno Dutra , de Andrade Jelmir Craveiro , da Silva Arianne Aparecida , Carvalho Nakédia M. F. , de Sousa Ana Maria Furtado , Conte-Junior Carlos Adam
Published: June 2024

In this work, novel nanocomposite films based on babassu coconut mesocarp and zinc oxide nanoparticles (ZnO NPs), synthesized by a green route, were produced for application as food packaging films. The films were prepared using the casting method containing different contents of ZnO NPs (0 wt%, 0.1 wt%, 0.5 wt%, and 1.0 wt%). The films were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), instrumental color analysis, and optical properties. The water vapor permeability (WVP) and tensile strength of films were also determined. The antimicrobial activity of the films against cooked turkey ham samples contaminated with Staphylococcus aureus was investigated. The results showed that incorporating ZnO NPs into babassu mesocarp matrices influenced the structure of the biopolymer chains and the color of the films. The BM/ZnO-0.5 film (0.5 wt% ZnO NPs) showed better thermal, mechanical, and WVP properties. Furthermore, the synergistic effect of babassu mesocarp and ZnO NPs in the BM/ZnO-0.5 film improved the antimicrobial properties of the material, reducing the microbial count of S. aureus in cooked turkey ham samples stored under refrigeration for 7 days. Thus, the films produced in this study showed promising antimicrobial packaging materials for processed foods.
Contribution of Gamma-Aminobutyric Amino Acid and Free Amino Acids to Low-Salt Whole-Wheat Bread through the Addition of Spice Extracts—An Approach Based on Taste Quality
Authors: Hisaki Kumiko , Sakamoto Chikae , Matsui Hina , Ueno Hiroshi , Ueda Yukiko
Published: June 2024

Given the link between excessive salt consumption and hypertension, reducing salt levels in bread, an important staple food in Japan, is essential. γ-Aminobutyric acid (GABA) has a salty taste-enhancing effect in vivo, and its production is influenced by the type of spice extract in vitro. However, the effects of spices on GABA levels, total free amino acid composition, and taste quality in whole-wheat bread remain unclear. Therefore, this study aimed to investigate whether the addition of spice extracts, which do not affect bread flavor and taste, can increase the GABA level in low-salt whole-wheat bread and whether free amino acid content affects the taste quality of bread using an automatic home bread maker. Through free amino acid composition analysis and sensory testing, we evaluated the influence of six spice extracts on the composition of free amino acids, including GABA, in whole-wheat bread. We found that cumin and anise extracts were effective in increasing the GABA level to approximately twice that in whole-wheat bread. Moreover, both the preference and saltiness of the bread were favorable, indicating that these extracts are useful for reducing the salt content of whole-wheat bread. This study provides a theoretical basis for guiding industrial production.
Improving the Meat and Meat Product Quality of Rare Pork Breeds and Genetic Types
Authors: Teixeira Alfredo , Álvarez-Rodríguez Javier
Published: June 2024

Pork is the most consumed meat globally, particularly in Asia, Europe, and America [...]
Antibacterial Activity Potential of Industrial Food Production Waste Extracts against Pathogenic Bacteria: Comparative Analysis and Characterization
Authors: Ziemah James , Ullrich Matthias S. , Kuhnert Nikolai
Published: June 2024

The Food and Agricultural Organization estimates a 17% loss in the food production chain, making it imperative to adopt scientific and technological approaches to address this issue for sustainability. Industrial food production waste and its value-added applications, particularly in relation to a wide variety of pathogenic microorganisms and the health-related effects have not been thoroughly investigated. This study explores the potential of food production waste extracts—lemon peel (LP), hot trub (HT), and coffee silverskin (CSS) as sources of bioactive compounds. Extraction was conducted using hydro-methanolic extraction with yields in LP (482 mg/1 g) > HT (332 mg/1 g) > CSS (20 mg/1 g). The agar diffusion assay revealed the substantial antibacterial activity of all three extracts against Erwinia Amylovora, Escherichia coli, Bacillus subtilis, and Bacillus aquimaris. All extracts demonstrated activity against Gram-positive and Gram-negative bacteria, displaying minimum inhibitory concentrations effective against pathogenic bacteria like Listeria monocytogenes, Staphylococcus aureus, Vibrio parahaemolyticus, and Salmonella enterica. Total phenolic content (TPC in mg GAE/1g) was 100, 20, and 100 for CSS, HT, and LP, respectively. Antioxidant activity by ABTS indicated IC50 of 3.09, 13.09, and 2.61 for LP, HT, and CSS, respectively. Also, the antioxidant activity of the extracts was further confirmed by DPPH assay with the best activity in CSS (9.84 GAEg−1) and LP (9.77 mg of GAEg−1) rather than in HT (1.45 GAEg−1). No adverse cytotoxic effects on HaCaT cells were observed. Pancreatic amylase inhibition demonstrated antidiabetic potential, with LP showing the highest levels (92%). LC-MS characterization identified polyphenols as the main compounds in CSS, prenylated compounds in HT, and flavanols in LP. The findings imply the potential sustainable use of food production waste in industry.
Combined Ascorbic Acid and Mild Heat Treatment to Improve the Quality of Fresh-Cut Carrots
Authors: Ma Sen , Zhou Ning , Fu Yinghua , Wang Jiayi
Published: June 2024

Mild heat (MH) treatment and ascorbic acid (AsA) addition can improve the quality of fresh-cut produce when used individually; however, their combined effect remains unclear. Herein, fresh-cut carrots were used as models to explore the effects of MH (50 °C)–AsA (0.5%) on quality properties including reactive oxygen species (ROS) metabolism, antioxidants, lignin metabolism, naturally present microbes, and inoculated pathogens (Escherichia coli O157: H7 and Salmonella Typhimurium) during storage (0–5 d, 4 °C). The results indicate that the antioxidant properties in the MH–AsA group were consistent with those of single treatments, resulting in a consistent ROS-scavenging effect. From day 3–5, lignin synthesis was significantly inhibited by MH–AsA as compared with single treatments, probably because the two enzymes (phenylalanine ammonia-lyase and peroxidase) responsible for lignin synthesis exhibited lower expressions. Microbial analysis revealed that MH–AsA treatment led to the lowest counts of both pathogens and aerobic mesophilic bacteria at 0–5 d. Conversely, the inhibitory effect of MH–AsA treatment on mold and yeast was consistent with the single treatments. These results suggest that MH–AsA is a low-cost and safe approach to improve the physiological characteristics of fresh-cut produce while reducing microbial risk.
A Type of Scale-Oriented Terrain Pattern Derived from Normalized Topographic Relief Layers and Its Interpretation
Authors: Nan Xi , Li Ainong , He Zhengwei , Bian Jinhu
Published: June 2024

Topographic scale characteristics contain valuable information for interpreting landform structures, which is crucial for understanding the spatial differentiation of landforms across large areas. However, the absence of parameters that specifically describe the topographic scale characteristics hinders the quantitative representation of regional topography from the perspective of spatial scales. In this study, false-color composite images were generated using normalized topographic relief data, showing a type of scale-oriented terrain pattern. Subsequent analysis indicated a direct correlation between the luminance of the patterns and the normalized topographic relief. Additionally, a linear correlation exists between the color of the patterns and the change rate in normalized topographic relief. Based on the analysis results, the issue of characterizing topographic scale effects was transformed into a problem of interpreting terrain patterns. The introduction of two parameters, flux and curl of topographic field, allowed for the interpretation of the terrain patterns. The assessment indicated that the calculated values of topographic field flux are equivalent to the luminance of the terrain patterns and the variations in the topographic field curl correspond with the spatial differentiation of colors in the terrain patterns. This study introduced a new approach to analyzing topographic scale characteristics, providing a pathway for quantitatively describing scale effects and automatically classifying landforms at a regional scale. Through exploratory analysis on artificially constructed simple DEMs and verification in four typical geomorphological regions of real terrain, it was shown that the terrain pattern method has better intuitiveness than the scale signature approach. It can reflect the scale characteristics of terrain in continuous space. Compared to the MTPCC image, the terrain parameters derived from the terrain pattern method further quantitatively describe the scale effects of the terrain.
Preoperative Echocardiographic Unknown Valvopathy Evaluation in Elderly Patients Undergoing Neuraxial Anesthesia during Major Orthopedic Surgery: A Mono-Centric Retrospective Study
Authors: Coviello Antonio , Cirillo Dario , Vargas Maria , de Siena Andrea Uriel , Barone Maria Silvia , Esposito Francesco , Izzo Antonio , Buonanno Pasquale , Volpe Serena , Stingone Andrea Gabriele , Iacovazzo Carmine
Published: June 2024

Background: The assessment of cardiac risk is challenging for elderly patients undergoing major orthopedic surgery with preoperative functional limitations. Currently, no specific cardiac risk scores are available for these critical patients. Echocardiography may be a reliable and safe instrument for assessing cardiac risks in this population. This study aims to evaluate the potential benefits of echocardiography in elderly orthopedic patients, its impact on anesthesiologic management, and postoperative Major Adverse Cardiac Events (MACEs). Methods: This is a retrospective, one-arm, monocentric study conducted at ‘’Federico II’’ Hospital—University of Naples—from January to December 2023, where 59 patients undergoing hip or knee revision surgery under neuraxial anesthesia were selected. The demographic data, the clinical history, and the results of preoperative Echocardiography screening (pEco-s) were collected. After extensive descriptive statistics, the χ2 test was used to compare the valvopathies and impaired Left Ventricular Function (iLVEF) prevalence before and after echocardiography screening and the incidence of postoperative MACE; a p-value < 0.05 was considered statistically significant. Results: The mean age was 72.5 ± 6.9, and the prevalence of cardiac risk factors was about 90%. The cumulative prevalence of iLVEF and valvopathy was higher after the screening (p < 0.001). The pEco-s diagnosed 25 new valvopathies: three of them were moderate–severe. No patients had MACE. Conclusions: pEco-s evaluation could discover unknown heart valve pathology; more studies are needed to understand if pEco-s could affect the anesthetic management of patients with functional limitations, preventing the incidence of MACE, and assessing its cost-effectiveness.
Post-Discharge Treatment Patterns among Patients Treated with Apixaban or Warfarin during Hospitalization for Venous Thromboembolism (VTE)
Authors: Coons James C. , Anupindi Vamshi Ruthwik , Doshi Riddhi , DeKoven Mitch , Dai Feng , Russ Cristina , Stellhorn Robert , Cheng Dong , Shi Liucheng , Deeba Serina , Hines Dionne M.
Published: June 2024

Background: Oral anticoagulants (OACs), such as apixaban and warfarin, are indicated for reducing the risk of recurrent venous thromboembolism (VTE) and are often initiated in the hospital. The aim of this study was to evaluate OAC continuity from inpatient to outpatient settings and the risk of recurrent VTE among patients with an initial event. Methods: This retrospective cohort study utilized hospital charge data and medical and prescription claims from 1 July 2016 to 31 December 2022 to identify adults treated with apixaban or warfarin while hospitalized for VTE. Patients were followed to assess switching or discontinuation post-discharge and the risk of recurrent VTE. The index date was the date of the first apixaban or warfarin claim within 30 days post-discharge. Results: Of the 19,303 eligible patients hospitalized with VTE, 85% (n = 16,401) were treated with apixaban and 15% (n = 2902) received warfarin. After discharge, approximately 70% had ≥1 fill for their respective apixaban or warfarin therapy. The cumulative incidence of discontinuation over the 6 months following index was 50.5% and 52.2% for the apixaban and warfarin cohorts, respectively; the cumulative incidence of switching was 6.0% and 20.9%, respectively. The incidence rates of recurrent VTE were 1.2 and 2.5 per 100 person-years for the apixaban and warfarin cohorts, respectively. Conclusions: The majority of patients continued their apixaban or warfarin therapy following hospital discharge; however, a considerable proportion either switched or discontinued OAC upon transitioning from inpatient care. Among those who continued therapy, discontinuation, switch, and recurrent VTE occurred less often with apixaban vs. warfarin.
Body Contouring as Gender-Affirming Surgery in Transgender Patients: A Systematic Review of the Current Literature
Authors: Aristizábal Alejandra , Ríos-Sánchez María , Escandón Joseph M. , DeRoberts Dean , Armenta Enrique , Del Corral Gabriel , Mascaro Andrés , Manrique Oscar J.
Published: June 2024

Background: There is an increasing demand for body contouring and gender-affirming surgeries, and so is the need to compare outcomes between techniques. Gender dysphoria is a discrepancy between gender identity and the sex assigned at birth. One way to address this is to perform procedures to enable patients to look according to their desired gender identity. Gaps in knowledge regarding the best approaches and which surgical techniques yield the most patient satisfaction remain. This article summarizes up-to-date studies, including upper and lower body contouring procedures. Methods: A systematic review was performed using terms related to body contouring in gender-affirming surgery for transgender patients. All articles included surgical and patient-reported outcomes following either chest or lower body contouring procedures. Results: 15 studies, including trans male chest wall contouring, trans female breast augmentation, and lower body contouring, with 1811 patients, fulfilled the inclusion criteria. The double incision (DI) techniques consistently resected more tissue and had better BODY Q scores than non-overweight patients. Bleeding was increased in periareolar, semicircular, and obese patients with DI techniques. Nipple depigmentation and sensation loss were more common with double-incision-free nipple graft techniques (DIFNG). Lower body contouring patients had average implant sizes bigger than 200 mL and reported 2 gluteal implant displacements, 1 exposure, and one rupture. Eight percent of patients who underwent large-volume fat grafting reported dissatisfaction due to fat reabsorption. Conclusions: The debate between the double incision and periareolar techniques continues. Variations of the DIFNG technique continue to be the most common approach; however, nipple depigmentation and loss of sensation are also more common with it. Regarding increased bleeding with periareolar techniques, there is still no evidence that hormonal therapy may be playing a role in it. For lower-body trans female contouring, implants could help with the longevity of contouring results in patients needing large-volume fat grafting. There is an increasing evaluation of gender-affirming body contouring patient-reported outcomes; however, there is still a need for a validated way to report satisfaction scores in lower body contouring. Validated surveys could help identify surgical candidates based on satisfaction patterns, specifically for transgender and non-binary patients.
Retrospective Analysis of Rectal Endoscopic Submucosal Dissection at Ordensklinikum Linz and Kepler Universitätsklinikum Linz
Authors: Swiridoff Nikolaj , Ziachehabi Alexander , Wewalka Friedrich , Spaun Georg , Alibegovic Vedat , Schöfl Rainer
Published: June 2024

Background and study aim: Endoscopic submucosal dissection is a minimally invasive endoscopic procedure for the removal of neoplastic benign and early malignant lesions in the gastrointestinal tract. In this study, we analyse the success and safety of rectal ESD at Linz hospitals, focusing on a specific endoscopist. Additionally, we examine whether there is a learning curve regarding success parameters. Methods: This retrospective study included all 102 patients who underwent endoscopic submucosal dissection of the rectum by a defined endoscopist at Ordensklinikum Hospital and Kepler University Hospital between December 2010 and May 2021. With the collected data, a descriptive statistic was carried out and regression analyses were performed. Results: The en bloc resection rate was 78.4% and the rate of lesions removed in healthy tissue was 55.6%. The average procedure time was 179 min and the complication rate was 7.8%. In total, 26.4% of cases showed carcinoma; in 25.9% of these cases, an oncologically curative resection was achieved with ESD. Follow-up data were available for 61.1% of cases, with recurrence being diagnosed in 3.6% of cases. A learning curve was observed regarding the rate of lesions removed in healthy tissue and the procedure time, but not regarding the en bloc resection rate. Conclusions: Endoscopic submucosal dissection is a safe method for the removal of large rectal adenomas and early carcinomas. The en bloc resection rate of the analysed procedures is within the range of comparable European studies. The rate of lesions removed in healthy tissue is below the R0 resection rate of the comparative literature; however, a learning curve could be observed in this parameter.
Anxiety and Depression in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension after the Removal of COVID-19 Pandemic Restrictions
Authors: Wieteska-Miłek Maria , Witowicz Anna , Szmit Sebastian , Florczyk Michał , Peller Michał , Dzienisiewicz Milena , Kurzyna Marcin
Published: June 2024

Background: There was increased risk of mental disturbances during the COVID-19 pandemic. Patients with chronic diseases, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), were particularly vulnerable. Our previous study showed high levels of fear of COVID-19 (FCV-19S), anxiety (HADS-A), and depression (HADS-D) in the second year of the pandemic among PAH/CTEPH patients. The aim of the present study was to assess changes in the levels of FCV-19S, HADS-A, and HADS-D after removing restrictions related to the COVID-19 pandemic. Methods: In this prospective, single-center study, 141 patients (62% females, 64% PAH) with a median age of 60 (range 42–72) years were included. Patients completed appropriate surveys in the second year of the pandemic, and then, after the restrictions were lifted in Poland (after 28 March 2022). Results: FVC-19S decreased significantly from 18 (12–23) to 14 (9–21), p < 0.001. The levels of anxiety (HADS-A ≥ 8 points) and depression (HADS-D ≥ 8 points) were abnormal in 26% and 16% of patients, respectively; these did not change at follow-up (p = 0.34 for HADS-A and p = 0.39 for HADS-D). Conclusions: Among PAH/CTEPH patients, fear of COVID-19 decreased significantly after the COVID-19 pandemic restrictions were removed, but anxiety and depression remained high, indicating that the COVID-19 pandemic was not a major factor in causing these disorders.
Do Ultrasound Lung Abnormalities Correlate to Biomarkers and Male Gender in Rheumatoid Arthritis Patients? A Monocentric Cross-Sectional Study
Authors: Bandinelli Francesca , Benucci Maurizio , Mallia Ilenia , Mauro Ilaria , Pecani Nikita , Li Gobbi Francesca , Manfredi Mariangela , Guiducci Serena , Lari Barbara , Grossi Valentina , Infantino Maria , Giannasi Gianfranco
Published: June 2024

Background: Lung ultrasound (LUS) is a tool of growing interest in Rheumatoid Arthritis (RA) oligo- symptomatic ILD to avoid. Objective: We aimed to evaluate (i) the prevalence of pleural (PLUS) and parenchymal (PAUS) abnormalities in LUS in the RA population and their possible correlation to biomarkers; (ii) the predictivity of gender, smoking habits, previous infections (past COVID-19 tuberculosis), and treatments; (iii) the differences in LUS between sexes. Methods: We collected the data of 155 (15 early and 140 late) RA patients with mild respiratory symptoms, evaluating PLUS and PAUS, in fourteen lung areas and also summing the scores (LUS-T). Results: Only 13/155 (8.4%) were completely negative; LUS correlated to age (all parameters p 0.0001), rheumatoid factor IgM (PLUS p 0.0006, PAUS p 0.02, LUS-T p 0.001) and ACPA (p 0.001, 0.006, 0.001, respectively), and PLUS also correlated to IL6 (p 0.02). The male gender was predictive of all LUS evaluations (p 0.001, 0.05, 0.001, respectively), which were higher than in women (p 0.001, 0.01, 0.001, respectively). Other potential risk factors were independent, except biological treatments, which showed a low predictivity to PLUS (p < 0.05). Conclusions: We can conclude that LUS is a useful technique in RA low respiratory symptoms and correlates with age, the most important RA biomarkers, and male sex.
Hypothalamic Hemangioma-like Pilocytic Astrocytoma in an Adult Patient: A Systematic Review with a Focus on Differential Diagnosis and Neurological Presentation
Authors: Costanzo Roberta , Rosetti Vittoria , Tomassini Alessia , Fuschillo Dalila , Lofrese Giorgio , Iacopino Domenico Gerardo , Tosatto Luigino , D’Andrea Marcello
Published: June 2024

Background: Pilocytic astrocytoma (PCA) are commonly observed as slow-growing noncancerous brain tumors in pediatric populations, but they can also occur in adults, albeit rarely. When located in diencephalic regions, particularly in the hypothalamus, they present unique diagnostic and management challenges due to their rarity and overlapping clinical and radiological features with other intracranial pathologies. This systematic review aims to provide a comprehensive understanding of hypothalamic PCA in adults, focusing on their differential diagnosis, neurological presentation, diagnostic modalities, treatment strategies. A case illustration is also described in order to better underline all the difficulties related to the diagnostic process. Material and methods: A systematic literature search was conducted in the PubMed/MEDLINE, Embase, and Scopus databases up to November 2023 to identify studies. Results: The systematic literature search identified a total of 214 articles. Following screening by title and abstract and full-text review, 12 studies were deemed eligible and are included here. Conclusions: Adult-onset PCA in diencephalic regions pose diagnostic challenges due to their rarity and overlapping features with other intracranial lesions. Advanced imaging techniques play a crucial role in diagnosis, while surgery remains the cornerstone of treatment. Multidisciplinary collaboration is essential for the optimal management and long-term follow-up of these patients.
The Trochlear Bisector as a New Landmark for Kinematic Alignment in Total Knee Arthroplasty: A Radiographic Study
Authors: Iacono Francesco , Bonanzinga Tommaso , Di Matteo Berardo , Iacomella Alberto , Delmedico Michelangelo , Gambaro Francesco Manlio , Favaro Alberto , Marcacci Maurilio
Published: June 2024

Background: In recent years, there has been considerable interest in prosthetic alignment techniques for total knee arthroplasty (TKA), particularly in the so-called kinematic alignment, which aims to restore the knee’s native alignment. However, implementing this technique requires specialized instruments and procedural steps that can be laborious. This study introduces the bisector of the trochlear groove as a reliable landmark for performing the distal femoral cut while maintaining parallelism with the native femoral joint line. Methods: Three orthopedic specialists assessed 110 X-ray images of full-leg, weight-bearing lower limbs obtained from healthy individuals between January 2021 and December 2022. The bisector of the trochlear groove was identified on the X-ray images, and the angle between this bisector and the femoral joint line was measured. The consistency of these measurements across repeated assessments and different examiners was evaluated. Results: The bisector of the trochlear groove was found to be perpendicular to the femoral joint line, with a mean angle of 89.4°. The inter-rater reliability was 68% within ±1.3° from the mean, while the intra-rater reliability was 82% within ±1.5° from the mean. Conclusions: These results suggest that by performing a femoral cut perpendicular to the bisector of the trochlear groove, surgeons can inherently restore the femoral joint line of the native knee in patients where the native joint line is no longer identifiable due to the effect of osteoarthritis. This method may offer a viable and straightforward alternative to the standard surgical technique currently practiced for kinematic alignment in TKA.
The Efficacy of CO2 Vaginal Laser in the Treatment of Recurrent, Post-Coital and Interstitial Cystitis: A Multicentric Prospective Study
Authors: Luvero Daniela , Silvagni Adele , Angioli Anna Maria , Filippini Maurizio , Plotti Francesco , Montera Roberto , De Cicco Nardone Carlo , Notaro Erika , Branda Francesco , Angioli Roberto
Published: June 2024

Background: This multicentric prospective study was carried out at Fondazione Policlinico Universitario Campus Bio Medico and Ospedale di Stato of St. Marino Republic. Between 1 January 2019, and 31 December 2022, all pre- and post-menopausal women diagnosed with recurrent, post-coital, and interstitial cystitis at both centers were included in the study. The main aim of the study was to assess the effectiveness of vaginal CO2 laser treatment, alone or combined with intravesical hyaluronic acid instillations, in managing cystitis symptoms, such as dysuria, pollakiuria, and urgency, across the entire patient cohort. The secondary objective was to investigate the reduction in number of annual cystitis episodes post-treatment. Methods: Each woman underwent three to four sessions of micro-ablative CO2 vaginal laser treatment. A follow-up examination was conducted 12 months after the final laser session (up to December 2023), during which a post-treatment VAS assessment evaluated dysuria, daily pollakiuria, and urgency. The enrolled patients recorded the number of cystitis episodes experienced during the 12-month pre- and post-treatment period. Results: Results indicated the laser’s efficacy in reducing the total number of cystitis episodes per year and an improvement in symptoms up to one year post-treatment. Greater efficacy of the CO2 laser treatment, particularly when combined with intravesical hyaluronic acid instillation, was observed in both pre- and post- menopausal women. Conclusions: Fractional CO2 laser therapy represents a safe and efficacious, non-hormonal approach for pre- and post-menopausal women diagnosed with recurrent, post-coital, and interstitial cystitis.
Endovascular Treatment of Abdominal Aortic Aneurysm: Impact of Diabetes on Endoleaks and Reintervention
Authors: Praca Charlotte , Sakalihasan Natzi , Defraigne Jean-Olivier , Labropoulos Nicos , Albert Adelin , Seidel Laurence , Musumeci Lucia
Published: June 2024

Background: Diabetes has a protective effect on abdominal aortic aneurysms (AAAs); however, there are contrasting reports on the impact of diabetes on endovascular aortic repair (EVAR) outcomes, endoleaks (ELs) being the major negative outcome. The present study characterizes ELs and their outcomes in AAA patients, diabetic or not. Methods: This single-center, retrospective, comparative study was carried out on 324 AAA patients who underwent elective EVARs between 2007 and 2016 at the University Hospital of Liège (Belgium). The primary endpoint was the incidence and effect of ELs on the evolution of the aneurysmal sac; the secondary endpoints were surgical reintervention and mortality rate. Diabetic and non-diabetic patients were compared with respect to various risk factors by logistic regression, while a Cox regression was used to analyze survival. Results: In AAA patients meeting the inclusion criteria (n = 248), 23% were diabetic. EL incidence was comparable (p = 0.74) in diabetic (38.7%) vs. non-diabetic (43.9%) patients. EL risk factors were age (HR = 1.04, p = 0.014) and fibrate intake (HR = 3.12, p = 0.043). A significant association was observed between ELs and aneurysm sac enlargement (p < 0.001), regardless of group (p = 0.46). Aneurysm sac regression per month for non-diabetic patients was −0.24 ± 0.013, while for diabetics it was −0.18 ± 0.027 (p = 0.059). Dyslipidemia (HR = 3.01, p = 0.0060) and sulfonylureas (HR = 8.43, p = 0.043) were associated with shorter EL duration, while diabetes (HR = 0.080, p = 0.038) and beta blockers (HR = 0.46, p = 0.036) were associated with longer EL duration. The likelihood of reoperation decreased with more recent surgery (OR = 0.90, p = 0.040), regardless of diabetic status. All-cause mortality was higher for the non-diabetic group (45.5% vs. 26.3%, p = 0.0096). Conclusions: Endoleak occurrence is a known risk factor for sac expansion. In diabetic patients, endoleaks lasted longer, and regression of the aneurysm sac tended to be slower. The number and type of reintervention was not related to the diabetic status of AAA patients, but overall survival was higher in patients with diabetes.
Therapeutic Apheresis Using a β2-Microglobulin Removal Column Reduces Circulating Tumor Cell Count
Authors: Komura Yasuo , Kimura Shintarou , Takaura Ayana , Hirasawa Yumi , Segawa Katsunori , Muranishi Hiromi , Imataki Osamu , Kumayama Yoshihisa , Homma Koichiro
Published: June 2024

An elevated serum β2-microglobulin (β2M) level is indicative of impaired glomerular filtration and prerenal diseases, such as malignant tumors, autoimmune disorders, and liver diseases. An elevated serum β2M level has been shown to promote metastasis via the induction of epithelial–mesenchymal transition (EMT) in cancer cells. However, the therapeutic potential of targeting β2M remains unclear. Here, we aimed to investigate the efficacy of Filtor, a small polymethyl methacrylate fiber-based β2M removal column, in reducing the β2M level and suppressing cancer cell-induced EMT and metastasis. We assessed the effects of Filtor on the changes in metastasis based on the number of circulating tumor cells (CTCs), which reflects the post-EMT cancer cell population. We performed therapeutic apheresis using Filtor on a male patient with sinonasal neuroendocrine carcinoma, a female patient with a history of colorectal cancer, and another female patient with a history of pancreatic ductal adenocarcinoma. Significantly low serum β2M levels and CTC counts were observed immediately and 4 weeks after treatment compared with those in the pretreatment phase. Moreover, the CTC count immediately after therapeutic intervention was markedly reduced, likely because Filtor had trapped CTCs directly. These findings suggest that therapeutic apheresis with Filtor can prevent cancer metastasis and recurrence by directly removing CTCs.
Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature
Authors: D’Adamo Christopher R. , Nelson Josephine L. , Miller Sara N. , Rickert Hong Maria , Lambert Elizabeth , Tallman Ruhm Heather
Published: June 2024

The prevalence of autism has been increasing at an alarming rate. Even accounting for the expansion of autism spectrum disorder diagnostic (ASD) criteria throughout the 1990’s, there has been an over 300% increase in ASD prevalence since the year 2000. The often debilitating personal, familial, and societal sequelae of autism are generally believed to be lifelong. However, there have been several encouraging case reports demonstrating the reversal of autism diagnoses, with a therapeutic focus on addressing the environmental and modifiable lifestyle factors believed to be largely underlying the condition. This case report describes the reversal of autism symptoms among dizygotic, female twin toddlers and provides a review of related literature describing associations between modifiable lifestyle factors, environmental exposures, and various clinical approaches to treating autism. The twins were diagnosed with Level 3 severity ASD “requiring very substantial support” at approximately 20 months of age following concerns of limited verbal and non-verbal communication, repetitive behaviors, rigidity around transitions, and extensive gastrointestinal symptoms, among other common symptoms. A parent-driven, multidisciplinary, therapeutic intervention involving a variety of licensed clinicians focusing primarily on addressing environmental and modifiable lifestyle factors was personalized to each of the twin’s symptoms, labs, and other outcome measures. Dramatic improvements were noted within several months in most domains of the twins’ symptoms, which manifested in reductions of Autism Treatment Evaluation Checklist (ATEC) scores from 76 to 32 in one of the twins and from 43 to 4 in the other twin. The improvement in symptoms and ATEC scores has remained relatively stable for six months at last assessment. While prospective studies are required, this case offers further encouraging evidence of ASD reversal through a personalized, multidisciplinary approach focusing predominantly on addressing modifiable environmental and lifestyle risk factors.
Driving Water through Sub-2-Nanometer Carbon Nanotubes
Authors: Liu Jian , Cao Wei
Published: June 2024

The ultra-low friction observed between water and carbon nanotubes has been extensively reported recently. In this study, we delve into the factors influencing the liquid–solid friction, including surface properties such as surface wettability and roughness of carbon nanotubes, as well as the driving forces involving temperature gradient and pressure drop. Utilizing non-equilibrium molecular dynamics simulations on carbon nanotube models with a diameter of ~1 nm, we observe a significant increase in water flux within a specific range of wettability, independent of roughness. This range is expected to shift to smaller values with increased pressure drop and temperature gradient. Both the mechanical transport coefficient and the thermo-osmosis coefficient exhibit a negative correlation with wettability, and roughness further decreases these coefficients. Through this work, we provide insights into the effects of surface properties on fluid transport through nanopores, contributing valuable information for the optimization of high-performance membrane processes.
Wear Characterization of Cold-Sprayed HEA Coatings by Means of Active–Passive Thermography and Tribometer
Authors: Sesana Raffaella , Corsaro Luca , Sheibanian Nazanin , Özbilen Sedat , Lupoi Rocco
Published: June 2024

The aim of this work is to verify the applicability of thermography as a non-destructive technique to quantify the wear performance of several high-entropy alloy coatings. Thermal profiles obtained from passive and active thermography were analyzed and the results were correlated with the classical tribological approaches defined in standards. HEA coatings made of several chemical compositions (AlxCoCrCuFeNi and MnCoCrCuFeNi) and realized by using different cold spray temperatures (650 °C, 750 °C, and 850 °C) were tested in a pin-on-disk configuration, with a dedicated pin developed for the wear tests. Then, the wear performances of each sample were analyzed with the hardness and wear parameter results. The thermal profiles of passive and active thermography allowed a complete characterization of the wear resistance and performance analysis of the coatings analyzed. The results are also compared with those presented in the literature.
Recovery of Metal Ions (Cd2+, Co2+, and Ni2+) from Nitrate and Sulfate on Laser-Induced Graphene Film Using Applied Voltage and Its Application
Authors: Wang Xiu-man , Su Tong , Chai Yujun
Published: June 2024

The urgent removal of Cd, Co, and Ni from nitrate and sulfate is essential to mitigate the potential risk of chemical pollution from large volumes of industrial wastewater. In this study, these metal ions were rapidly recovered through applying voltage on nitrate and sulfate, utilizing laser-induced graphene/polyimide (LIG/PI) film as the electrode. Following the application of external voltage, both the pH value and conductivity of the solution undergo changes. Compared to Co2+ and Ni2+, Cd2+ exhibits a lower standard electrode potential and stronger reducibility. Consequently, in both nitrate and sulfate solutions, the reaction sequence follows the order of Cd2+ > Co2+ > Ni2+, with the corresponding electrode adsorption quantities in the order of Cd2+ > Co2+ ~ Ni2+. Additionally, using the recovered Co(OH)2 as the raw material, a LiCoO2 composite was prepared. The assembled battery with this composite exhibited a specific capacity of 122.8 mAh g−1, meeting practical application requirements. This research has significance for fostering green development.