bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1
Authors: Katsu Yoshinao , Zhang Jiawen , Baker Michael E.
Published: March 2023

Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response of lamprey CR1 to steroids. The DBD in elephant shark mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), which are descended from a CR, lack these four amino acids, suggesting that a CR2 is their common ancestor. To determine if, similar to lamprey CR1, the presence of this insert in elephant shark MR and GR decreases transcriptional activation by corticosteroids, we inserted these four CR1-specific residues into the DBD of elephant shark MR and GR. Compared to steroid activation of wild-type elephant shark MR and GR, cortisol, corticosterone, aldosterone, 11-deoxycorticosterone and 11-deoxycortisol had lower transcriptional activation of these mutant MR and GR receptors, indicating that the absence of this four-residue segment in the DBD in wild-type elephant shark MR and GR increases transcriptional activation by corticosteroids.
Bioinformatics analysis of SH2D4A in Glioblastoma Multiforme to evaluate immune features and predict prognosis
Authors: Yang Tian , Sun Zhiyou , Li Chujun , Cheng Kexin , Ma Hongwei , Ren Yanhong , Zhang Zhengkui , Yu Rutong
Published: March 2023

Background: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. The predictive role of SH2D4A has been shown to be closely related to various cancers progression,but there is no comprehensive analysis of the clinical significance in glioblastoma. Hence, this study aimed to explore the relationship between the prognosis of GBM and SH2D4A expression.
Methods: The expression of SH2D4A in GBM was analyzed using TIMER2.0 and GEPIA, and validated by qRT-PCR experiments. The CGGA database analyzed the differential expression of SH2D4A in glioma and evaluated the impact of SH2D4A on the survival of glioma patients.LinkedOmics database and GeneMANIA database were studied for SH2D4A co-expression network. A lasso regression model and nomogram were constructed to assess the prognosis of GBM. TCGA database was used to do a GSEA to find functional differences. The relationship between SH2D4A expression and tumor-infiltrating immune cells was analyzed using xCELL, the CIBERSORT algorithm and the TIMER database.
Results: In GBM patients, we found that the expression of SH2D4A was upregulated, and the elevated expression of SH2D4A was strongly associated with the grade of the tumor. High SH2D4A expression was found to be a significant independent predictor of poor overall survival (OS) in GBM patients by survival curve analysis and multivariate cox regression analysis. GSEA revealed that SH2D4A was mainly enriched in extracellular matrix tissues, and the expression level of SH2D4A was inversely correlated with the level of infiltration of CD8+T cells, CD4+T cells, B cells, neutrophils and macrophages in GBM, but was positively correlated with the level of dendritic cell infiltration. Immunoassays suggest that altered SH2D4A expression may affect the immune infiltration of GBM tissues and thus affect the survival outcome of GBM.
Conclusion: In addition to being a possible prognostic marker and therapeutic target for GBM, SH2D4A may also accelerate the progression of GBM.
Combined electric and magnetic field therapy enhances bone repair and regeneration in two tibia osteotomy models in sheep.
Authors: Darwiche Salim E. , Kaczmarek Anna , Schwarzenberg Peter , Inglis Brendan J. , Lechmann Beat , Kronen Peter , Ferguson Stephen J. , Dailey Hannah , von Rechenberg Brigitte , Klein Karina
Published: March 2023

Background: Therapies using electromagnetic field technology show evidence of enhanced bone regeneration at the fracture site, potentially preventing delayed or non-unions.
Methods: Combined electric and magnetic field (CEMF) treatment was evaluated in two standardized sheep tibia osteotomy models: a 3 mm non-critical size gap model and a 17 mm critical size defect model augmented with autologous bone grafts, both stabilized with locking compression plates. CEMF treatment was delivered across the fracture gap twice daily for 90 mins, starting 4 days post-operatively (post-OP) until sacrifice (9 or 12 weeks post-OP, respectively). Control groups received no CEMF treatment. Bone healing was evaluated radiographically, morphometrically (micro-CT), biomechanically and histologically.
Results: In the 3 mm gap model, the CEMF group (n=6) exhibited higher callus mineral density compared to the Control group (n=6), two-fold higher biomechanical torsional rigidity and a histologically more advanced callus maturity (no statistically significant differences).
In the 17 mm graft model, differences between the control (n=6) and CEMF group (n=6) were more pronounced. The CEMF group showed a radiologically more advanced callus, a higher callus volume (p=0.003) and a 2.6x higher biomechanical torsional rigidity (p=0.024), combined with a histologically more advanced callus maturity and healing.
Conclusions: This study showed that CEMF therapy notably enhanced bone healing resulting in better new bone structure, callus morphology and superior biomechanical properties. This technology could transform a standard inert orthopedic implant into an active device stimulating bone tissue for accelerated healing and regeneration.
Folk Medical Practices and Treatments in African Fiction
Authors: Friday Akporherhe , Oghenerioborue Udi Peter , Emmanuel Esemedafe
Published: March 2023

This paper examines the enactment of cultural medical practices in the narratives of African writers. It aims at promoting the application of folk medicines in addressing the health problems of patients as enacted in artistic productions of fiction writers. It will celebrate, propagate and preserve these approaches to preventive and curative medical practices, which are indigenous to the African people. The study will be beneficial to health caregivers, researchers, health educators, health agencies and policy formulators, who are determined to promote the cultural healthcare system in society. It will reawaken and strengthen medical practitioners, patients and researchers, who may which to apply folk medical practices as an alternative treatment for health problems in socio-cultural settings. This research is field survey and library-based, with the literary texts carefully and purposively selected according to their thematic thrust and qualitatively analysed. Oral interviews were conducted to gather first-hand information and data on traditional medical practices from respondents, who have profound knowledge of the topic. The respondents were elderly men and women with profound knowledge of traditional medical practices, and they were drawn from various Urhobo communities, such as Ughelli, Akperhe-Olomu, Orogun, Okparabe, Edjekota-Ogor, and Agbarha-Otor. Among those interviewed were traditional medical practitioners, diviners, and patients, who often apply trado-medicines as alternative and supplementary treatments. Apart from the primary materials, scholarly works that are relevant to the current study were also consulted by the researchers. Findings showed that African societies are endowed with diverse forms of folk medicine, including the use of herbs, hydrotherapy, heat therapy, use of ointments, hot food as an intervention, talk therapy, etc. The study concluded that African writers are conscious of the utilitarian functions of their indigenous healthcare interventions, and so they integrate some of the practices into their artistic works, not only for the documentation but also to activate the awareness of readers on the efficacy of the traditional medicines. The various folk medical practices can serve as alternative and complementary treatments for people who cannot afford western healthcare interventions in contemporary societies.
Adverse Childhood Experiences and Health Risk Behaviours among the Undergraduate Health Campus Students
Authors:   Department of Paediatrics, Hospital Universiti Sains Malaysia, Kelantan, Malaysia, Majid Mardhiah , Ab Rahman Azriani ,   Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Taib Fahisham ,   Department of Paediatrics, Hospital Universiti Sains Malaysia, Kelantan, Malaysia,   Department of Paediatrics, School of Medical Sciences, Universiti  Sains Malaysia, Kelantan, Malaysia
Published: March 2023

Background: Adverse childhood experiences (ACEs) are linked with health risk behaviours (HRBs). The study aimed to evaluate ACEs in the undergraduate health campus of a public university located in the northeast of Malaysia and determine their association with HRBs. Methods: A cross-sectional study was performed by recruiting 973 undergraduate students at the health campus of a public university from December 2019 to June 2021. The World Health Organization (WHO) ACE-International Questionnaire and the Youth Risk Behaviour Surveillance System questionnaire were distributed using simple random sampling according to year of study and the selected batch of students. Descriptive statistics were used for demographic findings and logistic regression analyses were performed to determine the association between ACE and HRB. Results: The 973 participants (male [n = 245] and female [n = 728]) had a median age of 22 years old. The prevalence of child maltreatment among the study population was 30.2%, 29.2%, 28.7%, 9.1% and 6.1% for emotional abuse, emotional neglect, physical abuse, physical neglect and sexual abuse, respectively, among both sexes. The most commonly reported household dysfunctions were parental divorce/separation (5.5%). Community violence was 39.3% among the surveyed participants. The highest prevalence of HRBs among respondents was 54.5% from physical inactivity. The findings confirmed that those exposed to ACEs were at risk of HRBs and that a higher number of ACEs was associated with a higher number of HRBs. Conclusion: ACEs were highly prevalent among participating university students, ranging from 2.6%–39.3%. Hence, child maltreatment is an important public health problem in Malaysia.
Pure Juice Supplementation: Its Effect on Muscle Recovery and Sports Performance
Authors:   Defence Fitness Academy, National Defence University of Malaysia, Kuala Lumpur, Malaysia, Mohd Daud Siti Maizura , Mohd Sukri Nursyuhada ,   Defence Fitness Academy, National Defence University of Malaysia, Kuala Lumpur, Malaysia, Johari Mohamad Hanapi ,   Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia, Gnanou Justin ,   School of Medicine, International Medical University, Kuala Lumpur, Malaysia, Abdul Manaf Faizal ,   Defence Fitness Academy, National Defence University of Malaysia, Kuala Lumpur, Malaysia
Published: March 2023

Strenuous exercise causes increased production of reactive oxygen species (ROS), creating an imbalance between ROS and antioxidants. The reduced antioxidant defence leads to defective elimination of ROS and consequently, delayed-onset muscle soreness (DOMS). DOMS due to exhaustive or prolonged exercise typically peaks between 24 h and 72 h after exercise results in soreness, inflammation, pain and decreased muscle function. As a result, muscle strength will be reduced progressively and this situation might be detrimental to one’s athletic performance, especially amidst competition season. Therefore, supplementation to improve muscle recovery and sports performance has become a common practice among athletes. However, it is suggested to consume natural-based fruit-derived antioxidants as a more effective and safe nutritional strategy. Fruits containing a high amount of polyphenol protect muscle cells from excessive and harmful ROS due to their anti-inflammatory and antioxidant characteristics. To date, there are several expended studies on the consumption of supplements from various antioxidant-rich fruits to provide evidence on their effectiveness, giving better solutions and wider choices of supplementation to the athletes. Therefore, this review aims to provide a comprehensive overview of nutritional standpoint from previous literature on the effect of fruit juices supplementation on muscle recovery and sports performance.
Current Insights on Dyslipidaemia Management for Prevention of Atherosclerotic Cardiovascular Disease: A Malaysian Perspective
Authors:   Department of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia, Wan Ahmad Wan Azman , Rosman Azhari ,   Cardiology, National Heart Institute, Kuala Lumpur, Malaysia, Bavanandan Sunita ,   Department of Nephrology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia, Mohamed Mafauzy ,   Department of Endocrinology, Hospital Universiti Sains Malaysia, Kelantan, Malaysia, Sk Abdul Kader Muhamad Ali ,   Department of Cardiology, Serdang Hospital, Selangor, Malaysia, Muthusamy Tamil Selvan ,   Cardiology, Cardiac Vascular Sentral, Kuala Lumpur, Malaysia, Lam Kai Huat ,   Cardiology, Assunta Hospital, Selangor, Malaysia, Kasim Sazzli Shahlan ,   Faculty of Medicine, Cardiac Vascular and Lung Research Institute, Universiti Teknologi MARA, Selangor, Malaysia, Hoo Fan Kee ,   Department of Medicine, Faculty of Medicine, University Putra Malaysia, Selangor, Malaysia, Fegade Mayuresh ,   Novartis Corporation (Malaysia) Sdn. Bhd., Selangor, Malaysia, Looi Zhi Ling ,   Novartis Corporation (Malaysia) Sdn. Bhd., Selangor, Malaysia, Abdul Rahman Abdul Rashid ,   Department of Medicine, An-Nur Specialist Hospital, Selangor, Malaysia
Published: March 2023

Dyslipidaemia is highly prevalent in the Malaysian population and is one of the main risk factors for atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C) is recognised as the primary target of lipid-lowering therapy to reduce the disease burden of ASCVD. Framingham General CV Risk Score has been validated in the Malaysian population for CV risk assessment. The Clinical Practice Guidelines (CPG) on the management of dyslipidaemia were last updated in 2017. Since its publication, several newer randomised clinical trials have been conducted with their results published in research articles and compared in meta-analysis. This underscores a need to update the previous guidelines to ensure good quality care and treatment for the patients. This review summarises the benefits of achieving LDL-C levels lower than the currently recommended target of < 1.8mmol/L without any safety concerns. In most high and very high-risk individuals, statins are the first line of therapy for dyslipidaemia management. However, certain high-risk individuals are not able to achieve the LDL-C goal as recommended in the guideline even with high-intensity statin therapy. In such individuals, lower LDL-C levels can be achieved by combining the statins with non-statin agents such as ezetimibe and PCSK9 inhibitors. Emerging non-statin lipid-lowering therapies and challenges in dyslipidaemia management are discussed in this article. The review also summarises the recent updates on local and international guidelines for dyslipidaemia management.
Current Aspects of Bovine Leukemia
Authors: House J. A. , Glover F. L. , House C.
Published: March 2023

Bovine leukemia (leukosis, lymphosarcoma) is a disease which has caused serious economic consequences in Europe. Apparently there are not as many herds in the United States that show as high a percentage of tumors as are found in European cattle. It is difficult to evaluate the actual incidence of the clinical disease in cattle in the United States. In 1974, 4,669 cattle carcasses were condemned because of lymphosarcoma (14). In general, we can assume that these cattle did not demonstrate clinical signs of lymphosarcoma before slaughter, but were condemned due to the presence of internal tumors since only five cattle were condemned on ante-mortem inspection. It is difficult to determine the number of cattle observed to have tumors and not sent to slaughter, but rather "condemned" by the veterinarian and sent for tankage from the farm.
Pre-Weaning and Post-Weaning Nutrition
Authors: Williams Danny L. , Mahoney John. H.
Published: March 2023

Animal health is an important aspect of a preconditioning program; however, average daily gain and feed efficiency are extremely important if the program is to be profitable for the cow:calf producer. Not all calves are stressed to the same degree and as a result, not all calves will respond equally to a given treatment or nutritional level.
Bovine Salmonellosis
Authors: Butler D. G.
Published: March 2023

Recent research in the bovine relative to pathogenesis, epidemiology and prophylaxis in particular has challenged the validity of some of the conclusions about bovine salmonellosis derived from studies in other species. This presentation gives a brief overview of Bovine Salmonellosis with particular emphasis on those topics or concepts which have been or need to be further clarified.
Clinical Lameness in Dairy Cows in the Midwestern United States
Authors: Wells S. J. , Trent A. M.
Published: March 2023

The economic cost of lameness in dairy cattle has recently been reported as $7.69 per cow at risk of lameness (per cow in the herd) per year.1 This work, from herds with a 5% reported annual incidence of lameness, listed losses from culling, treatment and prevention costs, and death, but failed to include milk loss other than that from withheld milk due to treatment.
Development and Implementation of the Ontario Dairy Monitoring and Analysis Program
Authors: Kelton David F. , Martin S. Wayne , Hansen Donna S.
Published: March 2023

The importance of monitoring dairy cattle health and productivity at the herd level has become evident during the last decade (1). To monitor all aspects of the herd's performance, dairy producers and veterinarians need a variety of herd level information based on daily cow and farm events. These data are stored either on the farm or in central databases maintained by agencies serving the dairy industry. Unfortunately, in many cases the information useful for monitoring herd performance has not been gleaned from the existing cow level data, or has not been presented in a fashion that facilitates the monitoring process. The Ontario Dairy Monitoring and Analysis Program (ODMAP) evolved out of a perceived need for a herd level monitoring system that utilized the available herd data and was tailored to the characteristics of the Ontario dairy industry. The objectives of the ODMAP project included the establishment of a herd level database that could be used 1) to produce periodic summary reports useful to producers and veterinarians for monitoring herd performance, and 2) to investigate the herd level associations among measures of herd management, milk production, reproductive performance, animal health, and profitability. This manuscript outlines the development and implementation of the ODMAP and summarizes some of the data collected during the first year of the project.

Spanish and French summaries in PDF.
Evaluation of Animal Drug Residue Detection Methods
Authors: Bishop J. Russell , Whittier William D. , Duncan Susan E. , Jones Gerald M.
Published: March 2023

Animal drug residues in milk have been a major source of concern in the United States for several years. Many new methods to detect various residues at low levels have been introduced, revised or improved. At present the only "official" method approved by federal regulatory officials is for the detection of beta-lactam type antibiotics and is the Bacillus Stearothermophilus disc assay. The Food and Drug Administration (FDA) HPLC (High Pressure Liquid Chromatography) procedure is the "official" confirmatory method. A study was undertaken to evaluate 14 detection methods with 24 animal drug residues in milk to determine the sensitivity of each method and its ability to detect a residue at the FDA "recommended violative" level. No method tested is quantitative but give only a positive or negative indication of the presence of the drug. Milk samples were contaminated or "spiked" with known amounts of commonly available antimicrobial agents in 3 to 6 concentration levels. Fifteen replicates of each milk preparation were tested with applicable methods. The data revealed a total of 13 methods capable of detecting 23 drug residues at their respective levels of concern. Therefore, it would appear there exists adequate methodology for supplementation of the Bacillus stearothermophilus disc assay in regulatory milk testing.
Receiving Nutrition and Management for Feedlots
Authors: Cole N. Andy
Published: March 2023

Feeder calves encounter numerous physiological and psychological stressors during movement from one production point to another. Proper nutrition can help prepare the animal for a period of stress, reduce the adverse effects of stress, and enhance recovery from stressful periods. Additionally, inadequate nutrition can accentuate the adverse effects of stress.
Efficacy of Enrofloxacin in the Treatment of Bovine Clinical Mastitis
Authors: Pyörälä S. , Hirvonen J. , Pyörälä E.
Published: March 2023

Fluoroquinolones form a promising family of new bactericidal antimicrobials. Enrofloxacin is the first antimicrobial of this family available to veterinary medicine. Fluoroquinolones share a wide spectrum of acitivity but are most potent against gram-negative bacteria. They have a large volume of distribution and a low binding to plasma proteins, and are active at low concentrations. Compared with many other antimicrobials, they also have the advantage of being active against intracellular pathogens (8). Very few studies have been made of the pharmacokinetics of enrofloxacin in lactating cows. In one report, enrofloxacin was administered intravenously ( IV) or intramuscularly (IM) to three cows (3). After both routes of administration, the concentration of enrofloxacin in milk rapidly exceeded that in plasma. At a dose of 2.5 mg/kg b.w., inhibitory levels against coliform bacteria and most staphylococci(> 0.25 μg/ ml) were obtained in milk for approximately 24 hours. Using the same dose administered subcutaneously (SC), a concentration of 0.06 μg/ml or more was maintained in the serum and tissue of calves for 24 hours (6).

The bactericidal action of fluoroquinolones, their wide distribution in tissue and their activity against intracellular pathogens make them attractive for the treatment of staphylococcal mastitis. Enrofloxacin could solve the problem posed by the lack of a pharmacokinetically suitable antimicrobial for coliform mastitis. There are no published data on the efficacy of fluoroquinolones in the treatment of mastitis, except one preliminary report on norfloxacin in dry cow therapy (7).
Transmission of Paratuberculosis
Authors: Sweeney Raymond W.
Published: March 2023

The causative organism of paratuberculosis, Mycobacterium paratuberculosis, inhabits the intestinal tract and mesenteric lymph nodes of infected cows. While paratuberculosis has generally been regarded as an enteric infection, there is now evidence that the organism can disseminate to extra-intestinal sites such as uterus, supramammary lymph nodes, udder, sexual organs of bulls, and may be excreted directly in milk and semen.1,2,4-8,12,13,16,18 Recent studies would suggest that the likelihood of dissemination increases as extent of infection increases. Most clinical cases are likely to be disseminated.
Animal Welfare in Slaughter Plants
Authors: Grandin Temple
Published: March 2023

There are five basic causes of animal welfare problems in slaughter plants. They are: 1) Poorly designed or improper stunning and handling equipment. 2) Distractions which impede animal movement, such as sparkling reflections on a wet fioor, air hissing, high-pitched noise or air drafts blowing down the race towards approaching animals. These distractions can ruin the performance of a well designed system and cause animals to become excited. When this happens, prodding will be required to make them move. 3) Lack of employee training and poor supervision of employees by management. 4) Poor maintenance of equipment and facilities, such as malfunctioning stunners or worn, slick fioors which cause animals to slip and fall. 5) Poor condition of animals arriving at the plant, such as cripples and sick animals. Another problem is pigs and cattle from excitable genetic lines which are more likely to become agitated during handling. To maintain a high standard of welfare, all five problem areas must be addressed. A survey of 29 Canadian slaughter plants indicated that 27% had excellent non-slip fioors and 21% had slick fioors which would cause animals to slip. Twenty-four percent had high pitched motor noise or hissing air exhausts that caused animals to balk. Air drafts blowing down the race towards approaching animals were a problem in 9% of the plants. Air drafts will often impede animal movement.
Information on Regulation of Reproductive Cyclicity in Cattle
Authors: Wiltbank Milo C.
Published: March 2023

Reproductive cycles are regulated by hormones. The purpose of this paper is to give an overview of recent information on hormonal regulation of reproductive cycles in order to allow increased understanding of programs that are currently being developed or will be developed for improving reproductive efficiency in cattle.

Figure 1 shows a typical hormonal profile for 4 key reproductive hormones during the estrous cycle of the cow. Progesterone comes from the corpus luteum and increases after the time of ovulation and then decreases at the time of luteolysis. Prostaglandin (PG) F2a comes from the nonpregnant uterus and is the hormone responsible for luteolysis. AI, shown below PGF2a is secreted in distinct pulses near the time ofluteolysis. Estradiol-17B increases early in the cycle and after the time of luteolysis. This increase in estradiol causes estrus behaviour and the LH surge. The LH surge is responsible for ovulation of the preovulatory follicle. Ovulation occurs about 28 h after the initiation of the LH surge.

The remainder of this manuscript will provide more depth on this simplified view of the estrous cycle by summarizing some recent information on: regulation of follicular development, regulation of corpus luteum function, and how this information can be applied to understanding mechanisms involved postpartum anestrus and development of follicular cysts.
Results of Serological Testing of AABP Members for Antibody to M. paratuberculosis
Authors: Collins M. T. , Manning E. J. B.
Published: March 2023

The objective of the research was to determine if humans with a high risk of exposure to M. paratuberculosis had different levels of serum antibody to this infectious agent than persons with low risk of exposure.
Immunohistochemical Test on Skin Biopsies as a Method for Detection of Cattle Persistently Infected with Bovine Viral Diarrhea Virus
Authors: Brodersen Bruce W. , White Amy K. , Smith David R.
Published: March 2023

A novel rapid method for identification of cattle persistently infected (PI) with bovine viral diarrhea virus (BVDV) was examined. Individual cattle PI with BVDV serve as a source of infectious virus within cattle herds. Identification of cattle which are PI with BVDV is a clinical challenge, since many PI cattle appear clinically normal. BVDV infects a wide variety of tissues and cell types, particularly cells of the monocyte macrophage lineage. Cells of this lineage are present in the skin. BVDV antigen can be readily detected by the immunohistochemical (IHC) method.
Byt i świat w ontologii eleackiej
Authors: Piętka Dariusz
Published: March 2023

Przedmiotem artykułu są teorie pierwszych ontologów greckich: Ksenofanesa, Parmenidesa i Melissosa na temat bytu, jego jedności i tożsamości, z uwzględnieniem niektórych poglądów Zenona. Naczelnym problemem artykułu jest pytanie o naturę relacji bytu względem świata u filozofów eleackich. Celem jest opis sposobu rozumienia tego powiązania, zaproponowanego przez każdego z nich. W rezultacie analiz porównawczych, opierając się na badaniu zachowanych fragmentów tekstów starożytnych, okazało się, że Ksenofanes jest autorem koncepcji Jedno-Boga tożsamego ze światem, zaś Parmenides sformułował oryginalną teorię bytu transcendującego świat cielesny, ale stanowiącego jego rację tożsamości jako całości. Przedstawiona w artykule interpretacja poglądów Parmenidesa stanowi ujęcie odmienne od powszechnie przyjmowanego. Melissos natomiast wykorzystując Parmenidejski sposób rozumienia bytu jako czegoś jednego umieszcza go w świecie. Zbliża to poglądy Melissosa do poglądów Ksenofanesa. Każda z tych teorii nastręcza jednak wielu problemów interpretacyjnych, wynikających przede wszystkim z niewielkiej ilości tekstów źródłowych.

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Zgłoszono: 06/11/2022. Zrecenzowano: 13/12/2022. Zaakceptowano do publikacji: 20/12/2022
In the Quest for Natural Living: the Taoist and Jungian Roots of Arnold Mindell’s Therapeutic Path
Authors: Kowalski Arian
Published: March 2023

In this article, I would like to take a closer look at the philosophical meaning of the term “process,” which is a fundamental category in Arnold Mindell’s psychology. The Taoist origins of this concept go back to the Tao – the principle of the universe. Tao is the process of passing into each other the opposite aspects of the monastically understood Qi energy. Mindell was also inspired by the analytical psychology of Carl Gustav Jung, which emphasizes the importance of archetypal, unconscious mental processes and their impact on the ego through random thoughts, fantasies or dreams. Mindell distinguishes between a primary process (mental content that we are aware of) and a secondary process (mental content that we are not aware of) to explain what connects a person with her natural living – an unadulterated existence through rigid boundaries between the two processes acquired during one’s upbringing. The purpose of this article is to explore the Jungian and Taoist roots of Mindell’s psychology and to characterize individual lives as confronting their entire processual being, thus becoming natural living.

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Received: 14/04/2022. Reviewed: 19/10/2022. Accepted: 24/10/2022.
Measuring the Effectiveness of Electricity Distribution in Indonesian Provinces using DEA Bootstrap
Authors:   Universitas Brawijaya, Rahmawati Amalia , Tri Wahyudi Setyo ,   Brawijaya University, Kresna Sakti Rachmad ,   Brawijaya University
Published: March 2023

Purpose The aims of this research are to measure the efficiency of electricity distribution in 33 Indonesian provinces from 2010 to 2019. Design/methodology/approach The efficiency was measured using a two-step bootstrap analysis, i.e. DEA BCC and DEA Bootstrap. Findings This study finds that the efficiency estimation uses DEA BCC overestimate and that the proximity between electrical sources and customers becomes one of the supporting factors for the electricity distribution process and reduces losses. Furthermore, workforce input, nameplate capacity, and network length will be adjusted to customers; electricity demand needs as a component of the electricity distribution process from plants to consumers. Research limitations/implications This study uses the output of the number of customers and the amount of electricity distributed while the input variables use the amount of labor, installed capacity, and length of the distribution network. Originality/value This study uses DEA Bootstrap and the variables used in the study is a combination of variables that have been proven to affect electricity distribution and have never been applied in Indonesia.
Nove terapije u liječenju Alzheimerove bolesti
Authors: Perković Romana , Tomić Svetlana , Jurić Stjepan , Gudelj Ema , Hrvoić Lovro
Published: March 2023

Razvoj medicine produžio je ljudski životni vijek, ali povećanjem udjela starogstanovništva raste i incidencija neurodegenerativnih bolesti kao što je Alzheimerova bolest. Donedavno je jedina opcija za liječenje Alzheimerove bolesti bila simptomatska terapija u obliku inhibitora kolinesteraze (rivastigmin, donepezil, galantamin) ili antagonista NMDA receptora (memantin). Pokušaji pronalaska potencijalne terapije koja ne ublažava samo kliničku sliku, već može i usporiti ili potpuno zaustaviti progresiju neurološkog i kognitivnog propadanja, usmjereni su na dvije osnovne morfološke karakteristike bolesti – amiloidne plakove i hiperfosforilirane tau neurofibrilarne snopiće, zbog čega se naziva antiamiloidnom i antitau terapijom. Taj se terapijski pristup temelji na inhibiciji sinteze beta-amiloida ili proteina tau, sprječavanju njihova taloženja u agregate ili uklanjanju nastalih patoloških oblika primjenom specifičnih protutijela. Jedan takav lijek, aducunumab (originalno ime Aduhelm), nedavno je odobrio FDA za liječenje blage Alzheimerove bolesti.
Amoksicilinski osip
Authors: Poslon Danijela , Banac Srđan
Published: March 2023

Cilj: Amoksicilinski osip je generalizirani makulopapulozni egzantem koji se javlja nakon primjene semisintetskih penicilina u liječenju bolesnika koji imaju klinički neprepoznatu infektivnu mononukleozu. Često se kod takvih bolesnika pogrešno postavlja dijagnoza alergije na penicilin. Cilj ovog rada bio je prikazati pojavu osipa u djevojčice koja je liječena amoksicilinom zbog znakova upale gornjih dišnih putova. Nije imala tipičnu kliničku prezentaciju infektivne mononukleoze. Prikaz slučaja: Četverogodišnja djevojčica primljena je zbog akutnih simptoma kataralne upale gornjih dišnih putova i vrućice do 39,7 °C uz zimicu i tresavicu, na što je uvedena terapija amoksicilinom. Nakon prve doze amoksicilina javio se osip – prvo na glavi, iza uški, da bi se zatim difuzno proširio „spustivši“ se na trup i ektremitete. S obzirom na perzistirajuću vrućicu, širenje i konfluiranje osipa i grlobolju, djevojčica je hospitalizirana. Pri prijamu je bio prisutan makulopapulozni eritematozni osip, crveno ždrijelo s hipertrofičnim tonzilama i uvećani angularni limfni čvorovi. CRP je iznosio 37,1, a krvna slika bila je obilježena relativnom neutrofilijom. Iz biokemijske analize seruma za izdvojiti su bile normalne vrijednosti transaminaza. Serologijom je potvrđena akutna infekcija Epstein-Barrovim virusom. Nakon simptomatskog liječenja kožni simptomi su se postupno povukli. Pacijentica je četvrtog dana hospitalizacije postala afebrilna, a šestog dana otpuštena je kući. Zaključak: Patogeneza ovakvog kožnog osipa još je uvijek nedovoljno istražena. Najčešće je riječ o prolaznoj imunološkoj reakciji zbog virusne infekcije, a ne o razvoju prave alergijske reakcije na amoksicilin, na što se najčešće u praksi pogrešno posumnja. Zaključno, na infektivnu mononukleozu treba posumnjati čak i kada nema tipičnih kliničkih elemenata za tu bolest poput limfocitoze i povišenih vrijednosti transaminaza.
Investigation of the effect of spatial dispersion in a metal shell of a non-spherical magnetoplasmonic nanoparticle
Authors: Eremin Yu. A.  , Lopushenko V. V.
Published: March 2023

Based on the method of discrete sources, the effect of spatial dispersion in the metal shell of a magnetoplasmonic nanoparticle on the absorption of electromagnetic energy is studied. Hybrid particle is composed of a magnetic core Fe3O4 or Fe2O3 and a golden shell. The influence of the elongation of spheroidal particles on the level of energy absorption is considered. It is shown that taking into account the spatial dispersion in the shell leads to a decrease in the absorption cross section to 30% and is accompanied by a shift of the plasmon resonance to the short-wavelength region down to 25 nm. It is found that averaging the absorption cross section over the directions of propagation of external excitation and polarizations entails a threefold decrease in the level of absorbed energy. Keywords: discrete source method, plasmon resonance, spatial dispersion, generalized nonlocal response theory.
Усовершенствованный алгоритм FCDI для восстановления равновесия плазмы в токамаке
Authors: Коренев П.С. , Коньков А.Е. , Митришкин Ю.В. , Балаченков И.М. , Киселев Е.О. , Минаев В.Б. , Сахаров Н.В. , Петров Ю.В.
Published: March 2023

The paper presents the improved FCDI plasma equilibrium reconstruction algorithm implemented at the Globus-M2 tokamak. The algorithm has been improved to be able to operate in real time. The FCDI-FF (Fixed Filaments) operation mode was added, in which the plasma is modeled by current filaments at fixed positions. New user interface for the algorithm displays reconstructed plasma separatrix and contours of the internal magnetic surfaces, the poloidal flux distribution, and graphs of the reconstructed plasma parameters, including profiles of plasma pressure, poloidal current and safety factor q, plasma energy, poloidal beta and internal inductance, which can be exported in *.mat, *.json and G-eqdsk formats.
A Methodology for Evaluating and Scheduling Preventive Maintenance for a Thermo-Electric Unit Using Artificial Intelligence
Authors: Ahmed Wasan Mahmood , Ahmed Ahmed Abdulrasool , Abdulateef Osamah Fadhil
Published: March 2023

Flow-production systems whose pieces are connected in a row may not have maintenance scheduling procedures fixed because problems occur at different times (electricity plants, cement plants, water desalination plants). Contemporary software and artificial intelligence (AI) technologies are used to fulfill the research objectives by developing a predictive maintenance program. The data of the fifth thermal unit of the power station for the electricity of Al Dora/Baghdad are used in this study. Three stages of research were conducted. First, missing data without temporal sequences were processed. The data were filled using time series hour after hour and the times were filled as system working hours, making the volume of the data relatively high for 2015-2016-2017. 2018 was utilized as a test year to assess the modeling work and validate the experimental results. In the second step, the artificial neural networks approach employs the python program as an AI, and the affinity ratio of real data using the performance measurement of the mean absolute error (MAE) was 0.005. To improve and reduce the value of absolute error, the genetic algorithm uses the python program and the convergence ratio became 0.001. It inferred that the algorithm is efficient in improving results. Thus, the genetic algorithm provided better results with fewer errors than the neural network alone. This concludes that the shown network has superior performance over others and the possibility of its long-term predictions for 2030. A Sing time series helped detect future cases by reading and inferring system data. The development of appropriate work plans will lower internal and external expenses of the systems and help integrate other capabilities by giving correct data sources of raw materials, costs, etc. To facilitate prediction for maintenance workers, an interface has been created that facilitates users to apply them using the python program represented by entering the times, an hour, a day, a month, a year, to predict the type and place of failure.
A Perception-Based Survey on Innovation and Technology Adoption by Small-Scale Farmers in Semi-Arid Zimbabwe
Authors: Masere Tirivashe Phillip
Published: March 2023

This study was conducted with agricultural extension agents of semi-arid Zimbabwe to gather their perceptions on innovation and technology adoption by small-scale resource-constrained farmers, as well as the effect of their working conditions on the quality of service delivery to small-scale farmers. Data was solicited through focus group discussions (FGDs) and semi-structured interviews (SSIs) with all the public agricultural extension agents operating in the study area. It was found that agents were mainly hampered by lack of in-service training, transport and poor remuneration. Of all disseminated technologies during the last 20 years, respondents assessed that 17% had very low adoption rate, 26% had low adoption, 17% had average adoption, 26% had high adoption and only 13% had very high adoption. Bulky, expensive and risky technologies like tractors, solar driers, metal silos and bee farming were among the least adopted whereas hybrid seeds and value addition were very highly adopted. Reasons for the very low adoption were noted to be lack of capital, markets and information support on how to use new technology. Despite these challenges respondents indicated that small-scale farmers had the capacity to innovate and to adopt technology in the form of indigenous knowledge, willingness and commitment to learn and improve productivity, and labor. Agents suggested the strengthening of farmer-extension-research linkages so that technologies could be developed from some successful indigenous innovations, where possible and also to ensure the development of technology tailor-made to the needs of small-scale farmers, resource-endowments and biophysical conditions of their farming communities.
ОЦЕНКА РАБОЧЕЙ ЕМКОСТИ СИММЕТРИЧНЫХ КАБЕЛЕЙ С ПЛЕНКО-ПОРИСТО-ПЛЕНОЧНОЙ ПОЛИЭТИЛЕНОВОЙ ИЗОЛЯЦИЕЙ
Authors: Баннов В.В. , Попов Б.В. , Попов В.Б.
Published: March 2023

Показано, что для управления непрерывными процессами наложения изоляции на токопроводящую медную жилу для каждого типа симметричного кабеля нужно определять величину погонной емкости изолированной жилы. Для этого в работе получено аналитическое выражение рабочей емкости, позволяющее определять величину погонной емкости кабельной пары с пленко-пористо-пленочной полиэтиленовой изоляцией жил. На основе проведенных исследований даны практические рекомендации по настройке системы автоматического регулирования погонной емкости при наложении изоляции на экструзионной линии.
УСТОЙЧИВОСТЬ РАБОТЫ АЛГОРИТМОВ ЦОС КОГЕРЕНТНОГО ПРИЕМНИКА К БЫСТРОМУ ВРАЩЕНИЮ ПОЛЯРИЗАЦИИ, ВЫЗВАННОМУ ГРОЗОВЫМ РАЗРЯДОМ
Authors: Базаров Т.О. , Дорожкин А.Н. , Лукиных Т.О. , Наний О.Е. , Сенько М.А. , Трещиков В.Н.
Published: March 2023

В работе методом численного моделирования исследуется устойчивость работы алгоритмов цифровой обработки сигналов (ЦОС) когерентного приемника к быстрому вращению поляризации, вызванному ударом молнии в оптический кабель в грозотросе (ОКГТ). Установлено, что скорость изменения состояния поляризации (СП) является наиболее важным параметром, определяющим рост коэффициента ошибок (BER) в приемнике. Детальный анализ работы алгоритмов ЦОС в условиях быстрого вращения СП показал, что причиной роста коэффициента ошибок является ограниченное быстродействие блоков пересинхронизации и адаптивной фильтрации.
Mining of Thermostable Alpha-amylase Gene from Geothermal Springs using a Metagenomics Approach
Authors: Chauhan Garima , Kumar Vikas , Arya Meghna , Kumari Asha , Srivastava Akriti , Khanna Prashansa , Sharma Monica
Published: March 2023

The geothermal springs are said to contain the greatest diversity of undiscovered microorganisms, making them the best source for enzymes with economic significance. The untapped microbial diversity living in the geothermal springs can be mined for novel genes, bioactive substances, and industrially significant biocatalysts using the metagenomics technique. Metagenome was extracted from soil samples of various geothermal springs of India. Metagenome was screened for various carbohydrate degrading enzymes (amylase, cellulase, xylanase, amylopullulanase) using degenerate primers-based Polymerase chain reaction amplifications. Further amplicons were cloned, sequenced and analysis of data was done using various bioinformatics tools, e.g., Blast analysis, Protparam and phre2 program. We have isolated numerous enzymes, including cellulase, amylase, amylopullulanase, and xylanase, from diverse geothermal spring in different parts of India using sequence and function-based metagenomics. In this study, we describe the metagenomics-based isolation of a thermostable amylase from the geothermal spring of Odisha. The amylase gene (1503 bp) was amplified using the metagenome as a template using degenerate primers and cloned into the linearized T vector. The putative gene was likely to encode a protein of 469 amino acids with a molecular weight of 53895.05 Da with pI-7.78. Sequence analysis showed its maximum identity of 98.95% with Bacillus licheniformis alpha-amylase gene. Homology modeling of the amylase protein was done using the phyre2 program, which shows it belongs to the (trans) glycosidase superfamily and contains the catalytic TIM alpha/beta-barrel fold. Hence, we can conclude that geothermal springs are hotspots for the mining of industrially robust biocatalysts.
Design and Fabrication of Automated Fire Fighting Robot
Authors: Vishwakarma Deepak , Srivastava Ayush , Singh Anand Kumar , Tripathi Adarsh Mani , Yadav Sunil , Dubey Abhay Kumar
Published: March 2023

Abstract: Flames can cause critical harm and death toll, and it is pivotal to have powerful measures to control and douse them. The utilization of robots for firefighting activities has become progressively famous, provided their capacity to work in risky and testing conditions. In this paper, we present a point-by-point concentrate on the plan, improvement, and execution of a putting out fire robot. The putting out fires robot Is intended to explore through jumbled and temperamental conditions and furnished with sensors and cameras to identify and screen the fire. It is additionally equipped for conveying and sending firefighting gear, for example, quenchers and water hoses. The plan includes choosing the suitable sensors, actuators, and power sources to accomplish the ideal usefulness. The robot’s motion framework is intended to empower it to travel through lopsided territory and flotsam and jetsam, and it has a controller arm to get and work firefighting gear. The execution includes building the actual equipment and fostering the product that controls its activities. The equipment might be created utilizing a blend of off-the-rack parts and specially constructed parts. The product is intended to empower the robot to work independently in a putting out fires situation, utilizing Al calculations to identify and group various sorts of flames and select proper reactions in view of the seriousness of the circumstance. The robot is additionally intended to speak with human administrators, empowering them to screen the robot’s activities and settle on choices in view of the data given by the sensors
Improving students’ metacognitive abilities and creative thinking skills through STEM-based in online learning
Authors: Wilis Retno , Prayitno Baskoro Adi , Sunarno Widha , Anjirawaroj Suwanida
Published: March 2023

Creative thinking skills are crucial to current generations dealing with 21st-century challenges. However, studies on higher-order thinking skills remain limited. CTS can be easily empowered if students have good metacognitive abilities. This study analysed the effect of STEM-based online learning lesson plans on the CTS of students and metacognitive abilities on the inheritance of living things through online learning. The pretest-posttest research designs with a non-equivalent control group were used. The treatment given in the experimental class was the implementation of a STEM-based online learning lesson plan, while the control class was taught through traditional methods used by the teachers. The results of this study indicated that the CTS and metacognitive abilities of students in the experimental class were significantly higher than that of the control class [F(1,54) = 105.287, p = 0.000 and F(1,54) = 103.943, p = 0.000, respectively]. In conclusion, the STEM-based online learning lesson plan is effective in improving the CTS and metacognitive abilities of students.