bluuebunny/crossref_metadata_2025 huggingface dataset:
Complexity of Translating Analytics to Recent Cannabis Use and Impairment
Authors: DeGregorio Michael W , Kao Chiao-Jung , Wurz Gregory T
Published: February 2024

While current analytical methodologies can readily identify cannabis use, definitively establishing recent use within the impairment window has proven to be far more complex, requiring a new approach. Recent studies have shown no direct relationship between impairment and Δ9-tetra-hydrocannabinol (Δ9-THC) concentrations in blood or saliva, making legal “per se” Δ9-THC limits scientifically unjustified. Current methods that focus on Δ9-THC and/or metabolite concentrations in blood, saliva, urine, or exhaled breath can lead to false-positive results for recent use due to the persistence of Δ9-THC well outside of the typical 3–4 h window of potential impairment following cannabis inhalation. There is also the issue of impairment due to other intoxicating substances—just because a subject exhibits signs of impairment and cannabis use is detected does not rule out the involvement of other drugs. Compounding the matter is the increasing popularity of hemp-derived cannabidiol (CBD) products following passage of the 2018 Farm Bill, which legalized industrial hemp in the United States. Many of these products contain varying levels of Δ9-THC, which can lead to false-positive tests for cannabis use. Furthermore, hemp-derived CBD is used to synthesize Δ8-THC, which possesses psychoactive properties similar to Δ9-THC and is surrounded by legal controversy. For accuracy, analytical methods must be able to distinguish the various THC isomers, which have identical masses and exhibit immunological cross-reactivity. A new testing approach has been developed based on exhaled breath and blood sampling that incorporates kinetic changes and the presence of key cannabinoids to detect recent cannabis use within the impairment window without the false-positive results seen with other methods. The complexity of determining recent cannabis use that may lead to impairment demands such a comprehensive method so that irresponsible users can be accurately detected without falsely accusing responsible users who may unjustly suffer harsh, life-changing consequences.
One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy
Authors: Kanjanaruch Chutikun , Bochantin Kerri A , Dávila Ruiz Bethania J , Syring Jessica , Entzie Yssi , King Layla , Borowicz Pawel P , Crouse Matthew S , Caton Joel S , Dahlen Carl R , Ward Alison K , Reynolds Lawrence P
Published: February 2024

We hypothesized that restricted maternal nutrition and supplementation of one-carbon metabolites (OCM; methionine, folate, choline, and vitamin B12) would affect placental vascular development during early pregnancy. A total of 43 cows were bred, and 32 heifers successfully became pregnant with female calves, leading to the formation of four treatment groups: CON − OCM (n = 8), CON + OCM (n = 7), RES − OCM (n = 9), and RES + OCM (n = 8). The experimental design was a 2 × 2 factorial, with main factors of dietary intake affecting average daily gain: control (CON; 0.6 kg/d ADG) and restricted (RES; −0.23 kg/d ADG); and OCM supplementation (+OCM) in which the heifers were supplemented with rumen-protected methionine (7.4 g/d) and choline (44.4 g/d) and received weekly injections of 320 mg of folate and 20 mg of vitamin B12, or received no supplementation (−OCM; corn carrier and saline injections). Heifers were individually fed and randomly assigned to treatment at breeding (day 0). Placentomes were collected on day 63 of gestation (0.225 of gestation). Fluorescent staining with CD31 and CD34 combined with image analysis was used to determine the vascularity of the placenta. Images were analyzed for capillary area density (CAD) and capillary number density (CND). Areas evaluated included fetal placental cotyledon (COT), maternal placental caruncle (CAR), whole placentome (CAR + COT), intercotyledonary fetal membranes (ICOT, or chorioallantois), intercaruncular endometrium (ICAR), and endometrial glands (EG). Data were analyzed with the GLM procedure of SAS, with heifer as the experimental unit and significance at P ≤ 0.05 and a tendency at P > 0.05 and P < 0.10. Though no gain × OCM interactions existed (P ≥ 0.10), OCM supplementation increased (P = 0.01) CAD of EG, whereas nutrient restriction tended (P < 0.10) to increase CAD of ICOT and CND of COT. Additionally, there was a gain × OCM interaction (P < 0.05) for CAD within the placentome and ICAR, such that RES reduced and supplementation of RES with OCM restored CAD. These results indicate that maternal rate of gain and OCM supplementation affected placental vascularization (capillary area and number density), which could affect placental function and thus the efficiency of nutrient transfer to the fetus during early gestation.
Optimizing the Patient Experience for Women With Disabilities in the Breast Imaging Clinic
Authors: Net Jose M , Feliciano Yara Z , Podsiadlo Victoria , Dialani Vandana , Grimm Lars J
Published: February 2024

While there are varying opinions on what age to begin and at what interval to perform breast cancer screening, screening mammography is recommended for all women irrespective of disability. Unfortunately, women with disabilities are more likely to present with later-stage disease and higher mortality owing to the barriers for more widespread screening in this population. Women with disabilities may experience challenges accessing breast imaging services, and imaging centers may have suboptimal facilities and staff who are inexperienced in caring for this population. Efforts to increase accessibility by employing universal design to increase ease of access and provide training to improve the patient experience will go far to improve outcomes for patients with disabilities. To date, there exists no comprehensive guidance on how to improve breast cancer screening programs for women with disabilities. The purpose of this paper is to review barriers to screening faced by patients with disabilities, describe strategies to overcome these barriers, and provide guidance for radiologists and referring providers in selecting the best exam for the individual patient.
Policies or Prejudices? An Analysis of Antisemitic and Anti-Israel Views on Social Media and Social Surveys
Authors: Binstok Noam , Gould Eric D , Kaplan Todd
Published: February 2024

This paper examines the extent to which personal biases affect political views, in the context of how antisemitism influences opinions about Israel. Two empirical analyses are conducted. The first one analyzes social media chatter about Jews and Israel in the UK, revealing a strong, positive relationship between negative chatter about both of them at the daily-location level. In order to establish causality, social media chatter about a “Jewish” football team in the English Premier League (Tottenham) is used as an instrument for negative expressions about Jewish people to explain negativity toward Israel. The second empirical analysis uses the 2016 wave of the German Social Survey, which reveals a strong and robust relationship between several commonly used measures of antisemitic beliefs and holding anti-Israel views. A causal interpretation of this finding is supported by an IV analysis motivated by Voigtländer and Voth who show that Nazi indoctrination during the WWII period had a lifelong impact on antisemitic views. In both analyses, the IV estimates are considerably larger than OLS coefficients.
A convolutional neural network for creating near-surface 2D velocity images from GPR antenna measurements
Authors: Iqbal Ibrar , Xiong Bin , Peng Shanxi , Wang Honghua
Published: February 2024

In this research, our focus lies in exploring the effectiveness of a frequency-velocity convolutional neural network (CNN) in the efficient and non-intrusive acquisition of 2D wave velocity visuals of near-surface geological substances, accomplished through the analysis of data from ground-penetrating radar (GPR). To learn complex correlations between antenna readings and subsurface velocities, the proposed CNN model makes use of the spatial features present in the GPR data. By employing a network architecture capable of accurately detecting both local and global patterns within the data, it becomes feasible to efficiently extract valuable velocity information from GPR readings. The CNN model is trained and validated using a substantial dataset consisting of GPR readings along with corresponding ground truth velocity images. Diverse subsurface settings, encompassing different soil types and geological characteristics, are employed to gather the GPR measurements. In the supervised learning approach employed to train the CNN model, the GPR measurements serve as input, while the associated ground truth velocity images are utilized as target outputs. The model is trained using backpropagation and optimized using a suitable loss function to reduce the difference between the predicted velocity images and the actual images. The experimental results demonstrate the effectiveness of the proposed CNN method in accurately deriving 2D velocity images of near-surface materials from GPR antenna observations. Compared to traditional techniques, the CNN model exhibits superior velocity calculation precision and achieves high levels of accuracy. Moreover, when applied to unseen GPR data, the trained model exhibits promising generalization abilities, highlighting its potential for practical subsurface imaging applications.
Association between diet quality and ovarian cancer risk and survival
Authors: Cao Anlan , Esserman Denise A , Cartmel Brenda , Irwin Melinda L , Ferrucci Leah M
Published: February 2024

Background

Research on diet quality and ovarian cancer is limited. We examined the association between diet quality and ovarian cancer risk and survival in a large prospective cohort.

Methods

We used data from women in the prospective National Institutes of Health–AARP Diet and Health Study enrolled from 1995 to 1996 who were aged 50-71 years at baseline with follow-up through December 31, 2017. Participants completed a 124-item food frequency questionnaire at baseline, and diet quality was assessed via the Healthy Eating Index-2015, the alternate Mediterranean diet score, and the Dietary Approaches to Stop Hypertension score. Primary outcomes were first primary epithelial ovarian cancer diagnosis from cancer registry data and among those diagnosed with ovarian cancer all-cause mortality. We used a semi-Markov multistate model with Cox proportional hazards regression to account for semicompeting events.

Results

Among 150 643 participants with a median follow-up time of 20.5 years, 1107 individuals were diagnosed with a first primary epithelial ovarian cancer. There was no evidence of an association between diet quality and ovarian cancer risk. Among those diagnosed with epithelial ovarian cancer, 893 deaths occurred with a median survival of 2.5 years. Better prediagnosis diet quality, according to the Healthy Eating Index-2015 (quintile 5 vs quintile 1: hazard ratio [HR] = 0.75, 95% confidence interval [CI] = 0.60 to 0.93) and alternate Mediterranean diet score (quintile 5 vs quintile 1: HR = 0.68, 95% CI = 0.53 to 0.87), was associated with lower all-cause mortality. There was no evidence of an association between Dietary Approaches to Stop Hypertension score and all-cause mortality.

Conclusions

Better prediagnosis diet quality was associated with lower all-cause mortality after ovarian cancer diagnosis but was not associated with ovarian cancer risk.
The Effects of Placement and Order on Consent to Data Linkage in a Web survey
Authors: Burton Jonathan , Couper Mick P , Jäckle Annette
Published: February 2024

We report on an experiment in a supplemental web survey as part of a longitudinal study in the United Kingdom where we ask survey respondents to consent to two forms of data linkage to health records and to consent to be mailed a serology kit. We varied the placement (early, early in context, or late in the survey) and order (linkage first or serology first) of the consent requests. We also examine reasons for consent or non-consent. We find that order of the requests does not make much difference, but making the requests early in the survey significantly increases consent rates over asking them after a series of content-related questions (by 3.4 percentage points) or later in the survey (by 7.2 percentage points). This is consistent with previous research showing that early requests for consent in a survey have a positive effect. The main reason chosen for not consenting related to the personal nature of the information requested.
The transcription factor ThDOF8 binds to a novel cis-element and mediates molecular responses to salt stress in Tamarix hispida
Authors: Wang Peilong , Wang Danni , Li Yongxi , Li Jinghang , Liu Baichao , Wang Yuanyuan , Gao Caiqiu
Published: February 2024

Salt stress is a common abiotic factor that restricts plant growth and development. As a halophyte, Tamarix hispida is a good model plant for exploring salt-tolerance genes and regulatory mechanisms. DNA-binding with one finger (DOF) is an important transcription factor (TF) that influences and controls various signaling substances involved in diverse biological processes related to plant growth and development, but the regulatory mechanisms of DOF TFs in response to salt stress are largely unknown in T. hispida. In the present study, a newly identified Dof gene, ThDOF8, was cloned from T. hispida, and its expression was found to be induced by salt stress. Transient overexpression of ThDOF8 enhanced T. hispida salt tolerance by enhancing proline levels, and increasing the activities of the antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD). These results were also verified in stably transformed Arabidopsis. Results from TF-centered yeast one-hybrid (Y1H) assays and EMSAs showed that ThDOF8 binds to a newly identified cis-element (TGCG). Expression profiling by gene chip analysis identified four potential direct targets of ThDOF8, namely the cysteine-rich receptor-like kinases genes, CRK10 and CRK26, and two glutamate decarboxylase genes, GAD41, and GAD42, and these were further verified by ChIP–quantitative-PCR, EMSAs, Y1H assays, and β-glucuronidase enzyme activity assays. ThDOF8 can bind to the TGCG element in the promoter regions of its target genes, and transient overexpression of ThCRK10 also enhanced T. hispida salt tolerance. On the basis of our results, we propose a new regulatory mechanism model, in which ThDOF8 binds to the TGCG cis-element in the promoter of the target gene CRK10 to regulate its expression and improve salt tolerance in T. hispida. This study provides a basis for furthering our understanding the role of DOF TFs and identifying other downstream candidate genes that have the potential for improving plant salt tolerance via molecular breeding.
Isolation of Lactobacillus acidophilus strain and its anti-obesity effect in a diet induced obese murine model
Authors: Zheng Yanyi , Zhang Silu , Zhang Zhizhu , Zhang Tengxun , Teng Xin , Xiao Guoxun , Huang Song
Published: February 2024

Intestinal microbiota is a potential determinant of obesity, with probiotic bile salt hydrolase (BSH) as one of the key mechanisms in the anti-obesity effects. In this study, we present a Lactobacillus acidophilus GOLDGUT-LA100 (LA100) with high BSH activity, good gastric acid and bile salt tolerance, and a potential anti-obesity effect. LA100’s anti-obesity effects were evaluated in a high-fat diet-induced, obese mouse model. LA100 administration alleviates high-fat diet-induced pathophysiological symptoms, such as body weight gain, high serum glucose and cholesterol level, hepatic lipid accumulation, and adipose inflammation. These results demonstrate concrete anti-obesity benefit in animal models and show promising applications in future clinical studies.
Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics
Authors: Tate David F , Wade Benjamin S C , Velez Carmen S , Bigler Erin D , Davenport Nicholas D , Dennis Emily L , Esopenko Carrie , Hinds Sidney R , Kean Jacob , Kennedy Eamonn , Kenney Kimbra , Mayer Andrew R , Newsome Mary R , Philippi Carissa L , Pugh Mary J , Scheibel Randall S , Taylor Brian A , Troyanskaya Maya , Werner John K , York Gerald E , Walker William , Wilde Elisabeth A
Published: February 2024

Introduction

MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild TBI (mTBI) are mixed, making the findings difficult to interpret. As such, additional research is needed to continue to elucidate the relationship between the clinical features of mTBI and quantitative MRI measurements.

Material and Methods

Volumetric and diffusion imaging data in a sample of 976 veterans and service members from the Chronic Effects of Neurotrauma Consortium and now the Long-Term Impact of Military-Relevant Brain Injury Consortium observational study of the late effects of mTBI in combat with and without a history of mTBI were examined. A series of regression models with link functions appropriate for the model outcome were used to evaluate the relationships among imaging measures and clinical features of mTBI. Each model included acquisition site, participant sex, and age as covariates. Separate regression models were fit for each region of interest where said region was a predictor.

Results

After controlling for multiple comparisons, no significant main effect was noted for comparisons between veterans and service members with and without a history of mTBI. However, blast-related mTBI were associated with volumetric reductions of several subregions of the corpus callosum compared to non–blast-related mTBI. Several volumetric (i.e., hippocampal subfields, etc.) and diffusion (i.e., corona radiata, superior longitudinal fasciculus, etc.) MRI findings were noted to be associated with an increased number of repetitive mTBIs versus.

Conclusions

In deployment-related mTBI, significant findings in this cohort were only observed when considering mTBI sub-groups (blast mechanism and total number/dose). Simply comparing healthy controls and those with a positive mTBI history is likely an oversimplification that may lead to non-significant findings, even in consortium analyses.
Orbital evolution of eccentric perturbers under dynamical friction: crossing the sound barrier
Authors: Buehler Robin , Kolyada Roman , Desjacques Vincent
Published: February 2024

In a gaseous medium, dynamical friction (DF) reaches a maximum when the orbital speed of a (point-like) perturber moving on a circular orbit is close to the sound speed. Therefore, in a quasi-steady state, eccentric orbits of perturbers approaching the sound barrier (from below) should rapidly circularize as they experience the strongest drag at pericentre passage. To investigate this effect, we extend the solution for circular DF in a uniform gaseous medium to eccentric Keplerian orbits. We derive an approximation to the steady-state DF force, which is valid for eccentricities as high as e = 0.9 in a limited range of Mach number around the transition to supersonic regime. We validate our analytical result with 3D simulations of the gas density response. Although gaseous DF generally dissipates orbital energy, we find that it can be directed along the motion of the perturber near pericentre passage when the eccentricity is e ≳ 0.9. We apply our results to compute the long-time evolution of the orbital parameters. Most trajectories tend to circularize as the perturber moves into the supersonic regime. However, orbits with eccentricities e ≳ 0.8 below the sound barrier experience a slight increase in eccentricity as they loose orbital energy. Possible extensions to our analytical approach are also discussed.
Distant activity of long-period comets C/2019 L3 (ATLAS) and C/2020 P3 (ATLAS)
Authors: Sun Shaofeng , Shi Jianchun , Ma Yuehua , Zhao Haibin
Published: February 2024

Long-period comets C/2019 L3 (ATLAS) and C/2020 P3 (ATLAS) remain active at heliocentric distance greater than 4 au. Broad-band Charge-Coupled Device (CCD) photometry of long-period comets C/2019 L3 and C/2020 P3 is analysed in this paper. The observation was obtained with three telescopes: ZEISS-1000 at Simeiz Observatory, Maksutov at Abastumani Astrophysical Observatory, and ZTSh at Crimean Astrophysical Observatory. The R-band A(0)fρ values of C/2019 L3 range from (5043 ± 244) to (13611 ± 1874) cm, and tend to decrease first and then increase. The average colour indices of C/2019 L3 are B–V = 0.75 ± 0.06, V–R = 0.28 ± 0.05, and R–I = 0.21 ± 0.05. The reddening of C/2019 L3 exhibits variations during the observational runs, ranging from (13.75 ± 1.07) to (−15.69 ± 0.37) per cent/kÅ with an average value of (0.94 ± 0.23) per cent/kÅ. It possesses a non-steady coma since the average gradient of its surface brightness profile is −1.60. For comet C/2020 P3, its R-band A(0)fρ values range from (606 ± 31) to (869 ± 20) cm, the colour indices are B–V = 1.04 ± 0.09, V–R = 0.26 ± 0.05, and R–I = 0.76 ± 0.04, and the reddening is (−6.65 ± 0.01) per cent/kÅ. The colour indices of the two comets differ from those of other long-period comets. Compared with other long-period comets, comet C/2019 L3 is very active at heliocentric distance of ∼4 au, while C/2020 P3 is moderately active at heliocentric distance of ∼7 au.
Dust accumulation near the magnetospheric truncation of protoplanetary discs – II. The effects of opacity and thermal evolution
Authors: Li Rixin , Chen Yi-Xian , Lin Douglas N C
Published: February 2024

Dust trapping in the global pressure bump induced by magnetospheric truncation offers a promising formation mechanism for close-in super-Earths/sub-Neptunes. These planets likely form in evolved protoplanetary discs, where the gas temperature at the expanding truncation radius become amiable to refractory solids. However, dust accumulation may alter the disc opacity such that thermal evolution is inevitable. To better understand how thermodynamics affects this planet formation pathway, we conduct a suite of local dust evolution simulations in an idealized inner disc model. Our calculations take into account self-consistent opacity-dependent temperature changes as well as dust evaporation and vapour condensation. We find that disc thermal evolution regulates dust growth and evolution, discouraging any accumulation of small particles that drives the increase of opacity and temperature. Significant retention of dust mass takes place when the disc environments allow runaway growth of large solids beyond the fragmentation barrier, where small particles are then swept up and preserved. Our results further validate dust accumulation near disc truncation as a promising mechanism to form close-in planets.
dbCRAF: a curated knowledgebase for regulation of radiation response in human cancer
Authors: Liu Jie , Li Jing , Jin Fangfang , Li Qian , Zhao Guoping , Wu Lijun , Li Xiaoyan , Xia Junfeng , Cheng Na
Published: February 2024

Radiation therapy (RT) is one of the primary treatment modalities of cancer, with 40–60% of cancer patients benefiting from RT during their treatment course. The intrinsic radiosensitivity or acquired radioresistance of tumor cells would affect the response to RT and clinical outcomes in patients. Thus, mining the regulatory mechanisms in tumor radiosensitivity or radioresistance that have been verified by biological experiments and computational analysis methods will enhance the overall understanding of RT. Here, we describe a comprehensive database dbCRAF (http://dbCRAF.xialab.info/) to document and annotate the factors (1,677 genes, 49 proteins and 612 radiosensitizers) linked with radiation response, including radiosensitivity, radioresistance in cancer cells and prognosis in cancer patients receiving RT. On the one hand, dbCRAF enables researchers to directly access knowledge for regulation of radiation response in human cancer buried in the vast literature. On the other hand, dbCRAF provides four flexible modules to analyze and visualize the functional relationship between these factors and clinical outcome, KEGG pathway and target genes. In conclusion, dbCRAF serves as a valuable resource for elucidating the regulatory mechanisms of radiation response in human cancers as well as for the improvement of RT options.
An evolutionary learning-based method for identifying a circulating miRNA signature for breast cancer diagnosis prediction
Authors: Sathipati Srinivasulu Yerukala , Tsai Ming-Ju , Aimalla Nikhila , Moat Luke , Shukla Sanjay K , Allaire Patrick , Hebbring Scott , Beheshti Afshin , Sharma Rohit , Ho Shinn-Ying
Published: February 2024

Breast cancer (BC) is one of the most commonly diagnosed cancers worldwide. As key regulatory molecules in several biological processes, microRNAs (miRNAs) are potential biomarkers for cancer. Understanding the miRNA markers that can detect BC may improve survival rates and develop new targeted therapeutic strategies. To identify a circulating miRNA signature for diagnostic prediction in patients with BC, we developed an evolutionary learning-based method called BSig. BSig established a compact set of miRNAs as potential markers from 1280 patients with BC and 2686 healthy controls retrieved from the serum miRNA expression profiles for the diagnostic prediction. BSig demonstrated outstanding prediction performance, with an independent test accuracy and area under the receiver operating characteristic curve were 99.90% and 0.99, respectively. We identified 12 miRNAs, including hsa-miR-3185, hsa-miR-3648, hsa-miR-4530, hsa-miR-4763-5p, hsa-miR-5100, hsa-miR-5698, hsa-miR-6124, hsa-miR-6768-5p, hsa-miR-6800-5p, hsa-miR-6807-5p, hsa-miR-642a-3p, and hsa-miR-6836-3p, which significantly contributed towards diagnostic prediction in BC. Moreover, through bioinformatics analysis, this study identified 65 miRNA-target genes specific to BC cell lines. A comprehensive gene-set enrichment analysis was also performed to understand the underlying mechanisms of these target genes. BSig, a tool capable of BC detection and facilitating therapeutic selection, is publicly available at https://github.com/mingjutsai/BSig.
Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma
Authors: Odia Yazmin , Koschmann Carl , Vitanza Nicholas A , de Blank Peter , Aguilera Dolly , Allen Jeffrey , Daghistani Doured , Hall Matthew , Khatib Ziad , Kline Cassie , MacDonald Tobey , Mueller Sabine , Faison Shamia L , Allen Joshua E , Naderer Odin J , Ramage Samuel C , Tarapore Rohinton S , McGovern Susan Lynne , Khatua Soumen , Zaky Wafik , Gardner Sharon L
Published: February 2024

Background

This study evaluated the safety and pharmacokinetics (PK) of oral ONC201 administered twice-weekly on consecutive days (D1D2) in pediatric patients with newly diagnosed DIPG and/or recurrent/refractory H3 K27M glioma.

Methods

This phase 1 dose-escalation and expansion study included pediatric patients with H3 K27M-mutant glioma and/or DIPG following ≥1 line of therapy (NCT03416530). ONC201 was administered D1D2 at 3 dose levels (DLs; −1, 1, and 2). The actual administered dose within DLs was dependent on weight. Safety was assessed in all DLs; PK analysis was conducted in DL2. Patients receiving once-weekly ONC201 (D1) served as a PK comparator.

Results

Twelve patients received D1D2 ONC201 (DL1, n = 3; DL1, n = 3; DL2, n = 6); no dose-limiting toxicities or grade ≥3 treatment-related adverse events occurred. PK analyses at DL2 (D1-250 mg, n = 3; D1-625 mg, n = 3; D1D2-250 mg, n = 2; D1D2-625 mg, n = 2) demonstrated variability in Cmax, AUC0–24, and AUC0–48, with comparable exposures across weight groups. No accumulation occurred with D1D2 dosing; the majority of ONC201 cleared before administration of the second dose. Cmax was variable between groups but did not appear to increase with D1D2 dosing. AUC0–48 was greater with D1D2 than once-weekly.

Conclusions

ONC201 given D1D2 was well tolerated at all DLs and associated with greater AUC0–48.
Representation of the UK Parliament’s Power in the National Media: Too Weak, or Too Strong?
Authors: Russell Meg , James Lisa
Published: February 2024

Representations of UK parliamentary power in the popular media have attracted little attention, despite shaping citizens’ impressions of the institution. We begin to close this gap, through a content analysis of 657 articles in the national newspapers 2013–2019—a period straddling the Brexit referendum. Pre-referendum, media representations of parliamentary power were mixed, while afterwards, as parliament exerted influence over Brexit, it was presented as more powerful. But right-leaning newspapers shifted their normative position from lamenting parliament’s weakness to criticising its strength. Parliament hence faced a lose-lose situation, with key media outlets depicting it either as dangerously weak or dangerously strong.
The Needs and Experiences of Patients Returning to Work After Total Knee Arthroplasty and Total Hip Arthroplasty: A Systematic Review and Meta-Synthesis
Authors: Zhang Wenzhong , Ji Hong , Wang Ning , Sun Kangming , Xu Zhenzhen , Li Jing , Liu Cuihong , Sun Qingxiang , Wang Chunlei , Zhao Fengyi
Published: February 2024

Objective

The objective of this study was to conduct a systematic and comprehensive review of qualitative research to examine the physical and psychological needs, as well as work experiences, of patients undergoing total knee replacement and total hip replacement surgeries during their process of returning to work.

Methods

A systematic review and meta-synthesis of qualitative literature was conducted. A systematic search was conducted across 8 databases to identify qualitative or mixed-methods research on the needs and experiences of individuals with total knee replacement and total hip replacement who have returned to work. The search period extended from the inception of each database to March 2023. Two researchers independently utilized a predetermined search strategy to retrieve relevant English-language studies published in any year. The included studies were assessed for quality using the Critical Appraisal Skills Program appraisal tool. Findings from the studies were then summarized and integrated using the pooled integration method.

Results

There were 10 studies in total. Three key themes were identified from the original research: needs during the return to work process and rehabilitation training, faith and support to return to work, and constraints and challenges at work.

Conclusion

Health care professionals and employers should conscientiously consider the physical and psychological requirements of patients who have undergone total knee replacement and total hip replacement when they are resuming work, taking into account the specific constraints and challenges that may arise in the workplace. To ensure a seamless transition back to work, it is essential to develop tailored occupational interventions, implement comprehensive return to work programs, and offer patients sufficient understanding and support.

Impact

The findings of this study offer valuable insights into the physical and psychological needs, as well as the work experiences, of patients who have undergone total knee replacement and total hip replacement during their reintegration into the workforce. These findings have the potential to assist health care professionals and employers in providing enhanced support to facilitate successful return-to-work outcomes for patients.
Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia
Authors: Mo Fan , Zhao Han , Li Yifan , Cai Huanhuan , Song Yang , Wang Rui , Yu Yongqiang , Zhu Jiajia
Published: February 2024

Background and Hypothesis

Neuroimaging studies investigating the neural substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed results, which may be reconciled by network localization. We sought to examine whether AVH-state and AVH-trait brain alterations in schizophrenia localize to common or distinct networks.

Study Design

We initially identified AVH-state and AVH-trait brain alterations in schizophrenia reported in 48 previous studies. By integrating these affected brain locations with large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we then leveraged novel functional connectivity network mapping to construct AVH-state and AVH-trait dysfunctional networks.

Study Results

The neuroanatomically heterogeneous AVH-state and AVH-trait brain alterations in schizophrenia localized to distinct and specific networks. The AVH-state dysfunctional network comprised a broadly distributed set of brain regions mainly involving the auditory, salience, basal ganglia, language, and sensorimotor networks. Contrastingly, the AVH-trait dysfunctional network manifested as a pattern of circumscribed brain regions principally implicating the caudate and inferior frontal gyrus. Additionally, the AVH-state dysfunctional network aligned with the neuromodulation targets for effective treatment of AVH, indicating possible clinical relevance.

Conclusions

Apart from unifying the seemingly irreproducible neuroimaging results across prior AVH studies, our findings suggest different neural mechanisms underlying AVH state and trait in schizophrenia from a network perspective and more broadly may inform future neuromodulation treatment for AVH.
In-vitro and preclinical testing of bacillus subtilis UBBS-14 probiotic in rats shows no toxicity
Authors: Negi Ankit , Pasam Tulasi , Farqadain Syed Muhammad , Mahalaxmi Y , Dandekar Manoj P
Published: February 2024

Introduction

Probiotics made from Bacillus subtilis provide a wide spread of health benefits, particularly in the treatment of diarrhea and gastrointestinal problems. Herein, we employed in vitro and in vivo paradigms to assess the potential adverse effects and toxicity of B. subtilis UBBS-14.

Materials and methods

According to Organization for Economic Co-operation and Development (OECD) 423 and 407 requirements, a preclinical investigation was conducted in male and female Sprague-Dawley rats. Acute toxicity was examined following a single peroral (PO) administration of 5,000 mg/kg body weight (bw) i.e. equivalent to 500 billion colony-forming units (CFU) per kg bw. Single administration of B. subtilis UBBS-14 showed no mortality or adverse effects until the 14-day observation period, indicating LD50 is >5,000 mg/kg bw.

Results

Incubation of B. subtilis UBBS-14 with Caco2, HT29, and Raw 264.7 cell lines, showed no cytotoxic effects. This probiotic strain was also found responsive to the majority of antibiotics. For a 28-day repeated dose toxicity study, rats were administered 100, 500, and 1,000 mg/kg bw daily once (10, 50, and 100 billion CFU/kg bw/day, respectively) doses of B. subtilis UBBS-14. No notable changes were seen in the morphology, weight, and histopathology of the critical internal organs. The haematological, biochemical, electrolyte (sodium, potassium, chloride, and calcium), and urine analytical results were within the normal range and equivalent to the vehicle-treated group.

Conclusion

B. subtilis UBBS-14's no-observed-effect level (NOEL) was thus determined to be >1,000 mg/kg bw/day following a 28-day oral dosing.
A Qualitative Concept Elicitation Study to Understand Patient-Reported Symptoms and Impacts of Neisseria gonorrhoeae Infections in the United States
Authors: Kocaata Zeki , Currie Brooke , Beck Ekkehard , Zaiser Erica , Cutts Katelyn , Barnes Nicola , Meszaros Kinga
Published: February 2024

Background

Gonorrhea is the second most common bacterial sexually transmitted infection in the United States, with rising rates. Emerging antimicrobial resistance threatens public health, and vaccines are in development. This study documents patient-reported gonorrhea symptoms and health-related quality-of-life (HRQoL) impact in women who have sex with men (WSM), men who have sex with women (MSW), and men who have sex with men (MSM).

Methods

Semistructured qualitative interviews were conducted (April 2021–March 2022) among US adults with recent (≤6 months) confirmed gonorrhea. Concept saturation was achieved, confirming adequate participant numbers to meet objectives. Elicited symptom and HRQoL impacts were used to develop a conceptual disease model. Common patient-reported outcome measure (PROM) items were compared with elicited concepts.

Results

Thirty-two participants (15 WSM, 8 MSW, and 9 MSM) were included. Eight were asymptomatic, 6 had repeat infections, and 5 women and 4 men had complications (i.e., infertility or pelvic inflammatory disease, and urethritis, respectively).

The most frequently reported symptoms were vaginal discharge (n = 11 of 12), dysuria (n = 10 of 12), and abdominal/vaginal pain (n = 9 of 12) for symptomatic WSM; dysuria (n = 5 of 6) and penile discharge (n = 4 of 6) for symptomatic MSW; and throat, testicular, or rectal pain (n = 4 of 6) for symptomatic MSM. All (symptomatic and asymptomatic) participants reported HRQoL impacts including negative emotional experiences (n = 31 of 32), and interference with sexual activity (n = 30 of 32), relationships (n = 24 of 32), and social life (n = 17 of 32). Concepts were poorly represented in existing PROMs.

Conclusions

Participants reported a diverse range of symptoms and HRQoL impacts, to help inform the value of new treatment and prevention options. More research is needed to quantify patient burden and develop PROMs.
Tata Motors Limited: strategic journey towards electric vehicle
Authors: Nayak Digbijay , Sahay Arunaditya
Published: February 2024

Learning outcomes

The case study has been prepared for management students/business executives to understand electric vehicle (EV) business, business environment, industry competition and strategic planning and strategy implementation.

Case overview/synopsis

The size of the Indian passenger vehicle market was valued at US$32.70bn in 2021; it was projected to touch US$54.84bn by 2027 with a Compound Annual Growth Rate (CAGR) of more than 9% during the period 2022–2027. The passenger vehicle industry, a part of the overall automotive industry, was expected to grow at a rapid pace, as the Indian economy was rising at the fastest rate. However, the Government of India (GoI) had put a condition on the growth scenario by mandating that 100% of vehicles produced would be EVs by 2030. Tata Motors (TaMo), a domestic player in the market, had been facing a challenging competitive environment. Although it had been incurring losses, it had successfully ventured into the EV business. TaMo had taken advantage of the first mover by creating an electric mobility business vertical to enable the company to deliver on its aspiration of providing innovative and competitive e-mobility solutions. TaMo leadership had been putting efforts to scale up the electric mobility business, thus, contributing to GoI’s plan for electric mobility. Shailesh Chandra, president of electric mobility business, had a big task in hand. He had to scale up EV production and sales despite insufficient infrastructure for charging and shortages of electronic components for manufacturing.

Complexity academic level

The case study has been prepared for management students/business executives for strategic management class. It is recommended that the case study is distributed in advance so that the students can prepare well in advance for classroom discussions. Groups will be created to delve into details for a specific question. While one group will make their presentation, the other groups will question the solution provided and give suggestions.

Supplementary materials

Teaching notes are available for educators only.

Subject code

CSS 11: Strategy.
Aerodynamic performance increase over an A320 morphing wing in transonic regime by numerical simulation at high Reynolds number
Authors: Abou Khalil Jacques , Jiménez Navarro César , El Jeaid Rami , Marouf Abderahmane , El Akoury Rajaa , Hoarau Yannick , Rouchon Jean-François , Braza Marianna
Published: February 2024

Purpose

This study aims to investigate the morphing concepts able to manipulate the dynamics of the downstream unsteadiness in the separated shear layers and, in the wake, be able to modify the upstream shock–boundary layer interaction (SBLI) around an A320 morphing prototype to control these instabilities, with emphasis to the attenuation or even suppression of the transonic buffet. The modification of the aerodynamic performances according to a large parametric study carried out at Reynolds number of 4.5 × 106, Mach number of 0.78 and various angles of attack in the range of (0, 2.4)° according to two morphing concepts (travelling waves and trailing edge vibration) are discussed, and the final benefits in aerodynamic performance increase are evaluated.

Design/methodology/approach

This article examines through high fidelity (Hi-Fi) numerical simulation the effects of the trailing edge (TE) actuation and of travelling waves along a specific area of the suction side starting from practically the most downstream position of the shock wave motion according to the buffet and extending up to nearly the TE. The present paper studies through spectral analysis the coherent structures development in the near wake and the comparison of the aerodynamic forces to the non-actuated case. Thus, the physical mechanisms of the morphing leading to the increase of the lift-to-drag ratio and the drag and noise sources reduction are identified.

Findings

This study investigates the influence of shear-layer and near-wake vortices on the SBLI around an A320 aerofoil and attenuation of the related instabilities thanks to novel morphing: travelling waves generated along the suction side and trailing-edge vibration. A drag reduction of 14% and a lift-to-drag increase in the order of 8% are obtained. The morphing has shown a lift increase in the range of (1.8, 2.5)% for angle of attack of 1.8° and 2.4°, where a significant lift increase of 7.7% is obtained for the angle of incidence of 0° with a drag reduction of 3.66% yielding an aerodynamic efficiency of 11.8%.

Originality/value

This paper presents results of morphing A320 aerofoil, with a chord of 70cm and subjected to two actuation kinds, original in the state of the art at M = 0.78 and Re = 4.5 million. These Hi-Fi simulations are rather rare; a majority of existing ones concern smaller dimensions. This study showed for the first time a modified buffet mode, displaying periodic high-lift “plateaus” interspersed by shorter lift-decrease intervals. Through trailing-edge vibration, this pattern is modified towards a sinusoidal-like buffet, with a considerable amplitude decrease. Lock-in of buffet frequency to the actuation is obtained, leading to this amplitude reduction and a drastic aerodynamic performance increase.
The ecosystem of disability inclusion in hospitality and tourism organisations: an integrative review and research agenda
Authors: Jamin Aziean , Gbadamosi Gbolahan , Stoyanova-Bozhkova Svetla
Published: February 2024

Purpose

This paper reviews the literature on disability inclusion (DI) in supply and demand chains of hospitality and tourism (H&T) organisations. The purpose of this study is to assess disability support and interventions within H&T organisations. Through the assessment, we identified gaps to recommend H&T scholars’ and practitioners’ knowledge of DI from new perspectives.

Design/methodology/approach

An integrative review was conducted to examine the published evidence on DI in H&T organisations. This study used high-ranking H&T journals from the Scopus and Web of Science databases between 2001 and 2023. In total, 101 empirical papers met the criteria for the review analysis.

Findings

DI focuses heavily on customer disabilities, with scant research on DI in H&T employment. The review emphasises the critical need for empirical research into the varied disability employment ecosystem within H&T organisations, focusing on social integration for inclusive workplaces.

Originality/value

This study contributes to the H&T literature, which previously overlooked the disability context in diversity. The research offers strategies for creating inclusive environments in the H&T industry for disabled consumers and producers.
Using machine learning to determine factors affecting product and product–service innovation
Authors: Bustinza Oscar F. , Molina Fernandez Luis M. , Mendoza Macías Marlene
Published: February 2024

Purpose

Machine learning (ML) analytical tools are increasingly being considered as an alternative quantitative methodology in management research. This paper proposes a new approach for uncovering the antecedents behind product and product–service innovation (PSI).

Design/methodology/approach

The ML approach is novel in the field of innovation antecedents at the country level. A sample of the Equatorian National Survey on Technology and Innovation, consisting of more than 6,000 firms, is used to rank the antecedents of innovation.

Findings

The analysis reveals that the antecedents of product and PSI are distinct, yet rooted in the principles of open innovation and competitive priorities.

Research limitations/implications

The analysis is based on a sample of Equatorian firms with the objective of showing how ML techniques are suitable for testing the antecedents of innovation in any other context.

Originality/value

The novel ML approach, in contrast to traditional quantitative analysis of the topic, can consider the full set of antecedent interactions to each of the innovations analyzed.
Contribution of innovation studies to the intellectual structure of the hospitality and tourism literature
Authors: Arici Hasan Evrim , Köseoglu Mehmet Ali , Aydin Cagdas , Aydin Ceren , Altinay Levent
Published: February 2024

Purpose

This study aims to identify the role of innovation research in formulating the intellectual structure of the hospitality and tourism literature by performing a bibliometric analysis.

Design/methodology/approach

In total, 6,255 journal articles on innovation were gathered from Scopus and analyzed using co-citation, bibliographic coupling and thematic content analyses. The most influential articles were also carefully read to reveal a nomological network of innovation research in hospitality and tourism scholarship.

Findings

Co-citation analysis reveals that there are six significant clusters in the field of innovation research. Various philosophical underpinnings might be used in different circumstances, with actor-network and Schumpeterian theory playing significant roles. A review of current works using bibliographic coupling reveals five interesting emerging research areas and makes numerous recommendations for when to conduct more studies. A review of influential articles displayed differences between the co-citation and bibliographic coupling analysis findings and produced a framework for further investigation of the knowledge field.

Originality/value

This paper is among the first integrative reviews on innovation research in hospitality and tourism by quantitatively reviewing published articles and qualitatively reviewing the content of the most influential studies.