bluuebunny/crossref_metadata_2025 huggingface dataset:
ЗРОСІЙЩЕННЯ ПРІЗВИЩ У ПРОЦЕСІ ДЕНАЦІОНАЛІЗАЦІЇ ГРОМАДЯН УКРАЇНИ
Authors: Хом’як Іван
Published: January 2024

У статті проаналізовано роль прізвищ у зміцненні відчуття національної єдности, причини їх видозмін; проілюстровано зросійщені прізвища-мутанти, зафіксовані в сучасному інформаційному просторі; охарактеризовано можливості відновлення власних прізвищ або трансформування їх відповідно до моделей українських антропонімів; обґрунтовано прізвища за джерелами походження й граматичним складом, запис їх згідно з чинним правописом; вмотивовано проблему повернення до життя генетично зумовлених антропонімів з метою зміцнення української ідентичности. Дослідники стверджують, що у прізвищі людини закодовано завдання роду. З огляду на це в умовах незалежної держави маємо можливість відновити правильність своїх прізвищ або трансформувати їх відповідно до моделей українських прізвищ. У статті проаналізовано типові правописні відхилення в носіїв сучасних прізвищ.
COMPETITIVE CREATIVITY BETWEEN TALENT MANAGEMENT AND SERVICE QUALITY: EVIDENCE FROM JORDAN INFORMATION TECHNOLOGY SECTOR
Authors: Alabbas Marwan Mowaffaq Ghazi , Daud Dazmin , Adnan Wardatul Hayat
Published: January 2024

Talent management encompasses a wide range of human resources management practices aimed at attracting and developing talented employees. This study examines the impact of talent management on service quality in Jordanian information technology companies, focusing on the perspective of talented employees and the role of competitive creativity. Data was collected from 341 employees at thirty different Jordanian companies using stratified random sampling techniques. The collected data was then analyzed using SPSS and AMOS SPSS analysis techniques to test the conceptual framework. The study findings demonstrate a significant positive impact of talent management on improving service quality, mediated through the indirect influence of competitive creativity. Furthermore, the direct effects of talent management practices such as talent attraction and talent succession planning were found to have a significant positive effect on service quality. On the other hand, the study reveals that other talent management practices, such as talent development, have a negative direct effect on service quality. Given that this study is the first to investigate the mediating role of competitive creativity between talent management and service quality in Jordan, the limitations of the study were carefully considered.
A COMPREHENSIVE CASE STUDY ON TRADITIONAL WEAVING OF WESTERN RAJASTHAN
Authors: Srivastava Ankita , Saxena Ankur
Published: January 2024

The present paper discusses an age-old craft practised in India named Pattu weaving. This weaving technique is based on the extra weft weave design. Along with the ground warp and weft, few extra bright colored yarns are used in this technique to weave beautiful motifs on the fabric during the weaving process. The craft follows the sustainable way of fabric manufacturing as the fabrics are made on the handloom and follow the traditional ways for pre-weaving process also. The craft becomes more relevant in the present scenario considering the fact that for the last few decades unsustainable practices have increased drastically due to the imbalance of demand and supply, scarcity of natural resources, advent of unsustainable technologies among the other factors. While traditionally, sustainable practices were an integral part of the lifestyle of human beings and balanced the eco-system of the earth. One of the ways for balancing the natural energy consumption is utilization of all natural resources wisely by reinventing traditional craft practices. Hence, the present study focuses on the materials, tools, techniques and processes used in the Pattu weaving craft. PASTLE analysis of the craft has also been done to understand the opportunity and challenges of the craft. Along with this, a comparative analysis of the traditional and contemporary raw materials, techniques, motifs, colour range and application of the craft have also been covered in this paper. For this study, the primary research is based on the information that was collected during Craft Research Documentation activity funded by the Ministry of Textiles, India. Data from Secondary research has also been added to strengthen the analysis.
UNIVERSAL ANDROID-BASED ATTENDANCE APPLICATION USING THE GEOFENCE METHOD
Authors: Prabowo Samuel , Ginanjar Rikip
Published: January 2024

Generally, companies usually apply attendance procedures using the fingerprint attendance machine every employee in the office without exception. A common problem that happens is in the marketing of employees who are more than once out of office in 1 day forget to do a presence that can affect salary reduction sanctions. As a solution to the problem, there should bepresence applications using Global Positioning System (GPS) technology and utilizing NFC (Near Field Communication) technology. By using this application, marketing personnel no longer need to perform a presence with fingerprints on the presence machine, but only need to carry a smartphone device equipped with GPS. The app works by recording employee attendance at the office location as an office entry status and recording the status outside of the office when the Marketing force leaves the office. In this system also implements the Geofence method as an indication of the radius in which the user can perform the attendance process
Gamificación educativa y dimensión afectiva del estudiantado: más que motivación extrínseca
Authors: Suárez Baeza Fátima Renée
Published: January 2024

Introducción: la gamificación es una tendencia que se ha puesto en boga en diferentes sectores, incluyendo el educativo, en el cual las investigaciones se han focalizado mayormente en los principios del diseño y la motivación del estudiante, arrojando en general resultados positivos en los ambientes de aprendizaje, en ese mismo sentido, al ser un tema de interés creciente, resulta necesario considerar aristas poco exploradas como son los factores emocionales. Objetivo: indagar la manera en que las estrategias de gamificación inciden en la dimensión afectiva de un grupo de estudiantes universitarios. Métodos: corresponde a un estudio de caso bajo el enfoque cualitativo, el cual se desarrolló en una institución particular del poniente de la ciudad de Mérida que ofrece la Licenciatura en Educación en la modalidad mixta, para recolectar los datos se realizaron observaciones, entrevistas grupales e individuales. Resultados: entre los principales hallazgos destaca que la experiencia del curso gamificado resultó ser un espacio liberador, en el cual el estudiantado conectaba sus emociones con su intelecto, escapando de forma momentánea de la rutina y del estrés diario que les ocasiona el combinar la escuela y el trabajo. Conclusión: las estrategias de gamificación promovieron la deconstrucción de las formas de sentir, aprender y vincularse en el aula.
„Minidrama“: ästhetisch-performativer (Literatur-)Unterricht
Authors: Jirku Brigitte E.
Published: January 2024

Minidramen können sowohl im Fremdsprachenunterricht wie auch im Literaturunterricht in der Fremdsprache zur Festigung der Sprachkenntnisse sowie der ästhetischen Vermittlung und Reflexion von Literatur und Kultur produktiv eingesetzt werden. Die Vorstellung einer dramapädagogischen Unterrichtseinheit anhand des Minidramas „Mutter lernt Englisch“ von Elke Heidenreich wird ergänzt von theoretischen Überlegungen über Literarizität und Performativität. Eine Auswahlbibliografie über Minidrama und Quellen zu Minidramen ergänzen die Erörterungen.
“I would like my students to feel like that too.” Reflections on engagement in drama-rich pedagogies with community/heritage languages teachers
Authors: Hogan Zoe
Published: January 2024

This article explores engagement and group flow in drama-rich pedagogies with community languages (also known as heritage languages) teachers. Flow is usually examined in terms of an individual experience of creativity (Csikszentmihalyi, 1997, 2008, 2014), where autotelic or intrinsically rewarding experiences are associated with a state of flow. Group flow refers to a collective state where attention is equally put on the task and others, because the task requires continuous social interaction (Hackert et al., 2022; Sawyer, 2004, 2007). Teaching Artists working with drama-rich pedagogies must balance individual creative contributions, group dynamics and the demands of the narrative to sustain engagement and bring about the conditions for group flow. This research found that engagement for the purposes of teacher professional development broadened to encompass autotelic engagement. Data also indicated that a deepening sense of autotelic engagement served to extend and reinforce participants’ teacher professional learning goals.
Determinación de E. coli /coliformes en muestras de lechugas iceberg obtenidas del Mercado 27 de febrero, agosto 2023
Authors: Aguilar Ortiz Emily Tamara , Saquicaray Morocho Jenny Alexandra , Torres Segarra Silvia Monserrath
Published: January 2024

Introducción: La contaminación generada en los alimentos se ha convertido en un problema de salud pública al producir grandes patologías en el hombre, en donde se estudia las distintas colonias microbiológicas como E. coli y coliformes. Estos grupos de bacterias se pueden identificar en distintos tipos de alimentos como las lechugas iceberg, por sus parámetros de producción como las malas prácticas agrícolas. Objetivo: Determinar la presencia de E. coli /coliformes en lechugas iceberg expendidas en el mercado 27 de febrero de la ciudad de Cuenca. Métodos: Estudio de carácter observacional descriptivo, de corte transversal en el período agosto 2023 en el cual se recolectaron 30 muestras para la identificación de E. coli/coliformes en lechugas iceberg. Resultados: La determinación de E. coli/coliformes en las 30 muestras de lechuga analizadas del mercado 27 de febrero de la ciudad de Cuenca nos indica un crecimiento del 30% para E. coli que determinan algún grado de contaminación y el 100% para coliformes que pasa los límites establecidos por la Normativa Sanitaria de Perú. Conclusiones: Se determinó la frecuencia de E. coli/coliformes en las muestras recolectadas de lechuga iceberg expendidas por los comerciantes del mercado 27 de febrero de la ciudad de Cuenca procedente de diversos factores de contaminación a lo largo de su producción, uno de ellos la calidad del agua de riego que está en contacto directo con este producto alimenticio. Área de estudio general: Bioquímica y Farmacia. Área de estudio específica: Microbiología de Alimentos. Tipo de estudio:  Artículo original / Original article.
Desain Taman Bugar Dan Pintar TK Islam Terpadu Al-Ma’Un, Di Kecamatan Dau, Kabupaten Malang
Authors: Kurniawan Hendra , Budiyono Debora , Sumiati Astri , Putri Sri Andika , Asnah Asnah
Published: January 2024

Lembaga pendidikan formal yang mendidik anak usia dini dikenal dengan Kelompok Bermain (KB) dan Taman Kanak-kanak (TK). Taman Kanak-Kanak merupakan bentuk pendidikan pra sekolah yang menyediakan program pendidikan dini yang diperlukan oleh siswa dalam menyesuaikan diri dengan lingkungannya dan untuk kehidupan selanjutnya. Pada TK Islam Terpadu Al-Ma’Un proses pembelajaran telah sesuai dengan esensi dari pendidikan anak usia dini. Namun demikian, dalam melaksanakan proses pembelajaran masih terbatas dengan penggunaan alat permainan dan belum memanfaatkan taman sekolah sebagai media pembelajaran. Pemanfaatan taman sekolah dalam proses pembelajaran melibatkan kreativitas guru dalam memanfaatkan dan mempraktekkannya sebagai media belajar. Oleh karena itu perlu menciptakan tempat bermain yang aman dan nyaman bagi murid TK sebagai ekoedukasi. Tujuan kegiatan Pengabdian Kepada Masyarakat adalah mendesain sebuah Taman Bugar dan Pintar TK Islam Terpadu Al-Ma’Un, di Kecamatan Dau, Kabupaten Malang. Metode yang digunakan adalah Participation Learning Action (PLA) dan Focussed Group Discussion (FGD). Hasil kegiatan Pengabdian Kepada Masyarakat adalah sebuah desain yang berkonsep meningkatkan kualitas akademik, kesehatan, dan peduli lingkungan. Konsep taman terdiri dari site plan, konsep fasilitas, dan konsep tanaman yang menjadi pedoman dalam mewujudkan Taman Bugar dan Pintar TK Islam Terpadu Al-Ma’Un.
Alat Sistem Penjemur Ikan Asin Otomatis Berbasis IoT (Internet Of Things)
Authors: Herwanto Prengki Rahmadan , Kalsum Toibah Umi , Alamsyah Hendri
Published: January 2024

The fishing industry is currently one of the choices of food ingredients for daily needs. In everyday life, we are familiar with salted fish. To process salted fish, the drying process is done manually so fishermen have to directly control the drying of salted fish using 5-6 fishermen and drying salted fish cannot be left alone because salted fish is very vulnerable to rainwater. To minimize damage to salted fish and make fishermen's work easier, technology for automatic drying of salted fish based on the internet of things has been developed. The components used in making this IoT-based salted fish dryer are NodeMcu, rain sensors, light sensors, and servo motors. This research uses experimental methods, this research was carried out on ANTB (Bengkulu Traditional Fishermen's Alliance) on the coast of Bengkulu. The results of the research, the salted fish drying equipment can be controlled remotely using the Blynk Platform with an ON-OF controller, opening the drying roof by detecting the bright light sensor and closing the drying roof by detecting the rain sensor, then monitoring the drying remotely using the Blynk Platform so that it can determine bright conditions by displaying the LDR sensor value and indicator light for the rain sensor.
Çocuk Evleri Hizmet Modelinde Psikososyal Destek Sağlayan Meslek Elemanlarının Deneyimleri: Sivil Toplum Kuruluşu Örneği
Authors: Yıldız Beyza Nur , Karataş Mustafa
Published: January 2024

Dünya üzerinde var olan sosyoekonomik ve kültürel sorunlardan en çok çocuklar olumsuz etkilenmekte, kimi zaman temel ihtiyaçları karşılanamamakta, sağlıklı bireyler olarak yetişmelerinin önüne geçilmektedir. Bu nedenle çocuklar aile desteğinden yoksun kalmakta, bazıları ise ihmal ve istismar durumlarıyla karşı karşıya kalmaktadır. Bu gibi durumlarda çocukların koruma altına alınma ihtiyacı ortaya çıkmaktadır. Yapılan araştırma ile; bir STK bünyesinde çalışan ve Devlet koruması altındaki çocuklara psikososyal destek sağlama deneyimi olmuş meslek elemanlarının, çocuk evleri hizmet modeline ve sunulan hizmetlere ilişkin düşünce ve değerlendirmelerinin incelenmesi amaçlanmıştır. Nitel araştırma yöntemi kullanılarak gerçekleştirilen araştırmanın örneklemini 20 meslek elemanı oluşturmaktadır. Meslek elemanları ile çocuk evlerindeki deneyimleri üzerine yarı yapılandırılmış görüşme formu aracılığıyla görüşmeler yapılmıştır. Araştırma sonucunda çocuk evlerinde psikososyal destek sağlayan meslek elemanlarının çocuk evleri hizmet modeline ve sunulan hizmetlere ilişkin olumlu görüşlerinin olduğu ancak süreç içerisinde uygulamaya yönelik birçok olumsuz durumla karşılaştıkları sonucuna varılmıştır.
Williams Sendromu Tanısı Almış Çocuğa Sahip Ebeveynlerin Anksiyete Düzeylerine İlişkin Araştırma
Authors: Coşkun Hakan , Güntay Amine , Güleç Yakuphan , Eviz Ömer , Ç:ıvak Ümit , Korkmazyürek Küçükdemir Ayşe , Erkul Ercem
Published: January 2024

Williams-Beuren Sendromu (WS) 1961 yılında John Cyprian Phipps Williams tarafından tespit edilen ve kromozom çiftlerinden yedinci çiftin silinmesi sonucunda ortaya çıkan çoklu sistemik bir kromozom bozukluğudur. WS tanısı almış çocuklar özel gereksinimli bireyler olduğundan dolayı çocukların ebeveynlerine daima bağımlı olması, sosyal hayatlarının sınırlı olması vb. etkenler nedeniyle ebeveynlerde anksiyeteye sebep olabilmektedir. Bu bağlamda çalışmanın amacı Türkiye’de WS tanısı almış çocuğa sahip olan ebeveynlerin yaşadıkları güçlüklerden ötürü oluşan anksiyete düzeylerinin araştırılmasıdır. Tarama modeliyle gerçekleştirilen araştırmaya WS tanısı almış çocuğa sahip Türkiye Williams Sendromlular Derneğine (TWSD) kayıtlı 118 ebeveyn katılmıştır. Veriler, araştırmacılar tarafından oluşturulan sosyo-demografik sorular ve Beck, Epstein, Brown ve Steer (1988) tarafından geliştirilen Beck Anksiyete Envanteri (BAE) aracılığıyla toplanmıştır. Verilerin analizinde ise, veriler normal dağılımdan geldiği için parametrik testlerden Pearson korelasyon testi, Bağımsız Örneklem t Testi ve Tek Yönlü Varyans Analizi kullanılmıştır. Elde edilen bulgular neticesinde ebeveynlerin medeni durumunun, çalışma durumunun, sahip olduğu çocuk sayısının, WS tanısı almış çocuğun ailenin kaçıncı çocuğu olduğunun, çocuğun WS tanılı olmasından dolayı kendilerini suçlamalarının ve son olarak kendileri olmadığında çocuğun bakımını kimin üstleneceği konusunda yaşadıkları kaygının anksiyete düzeylerini anlamlı bir şekilde etkilediği gözlemlenmiştir. WS tanısı almış çocuğa sahip ebeveynlerle daha yoğun ve etkin bir biçimde çalışılması ve WS tanısı almış çocuklara yönelik mikro, mezzo ve makro sosyal hizmet uygulamaları geliştirilmesi önerilmektedir.
Effects of Manohra Dance, the Cultural Heritage of UNESCO, on Physical Performance in Children
Authors: PONGSIRI Tatpıcha , PHONGAMPAİ Mantira , SRİKET Natthawee , SRİKET Phudis , SRİRUNGRANGCHAİ Krit , SUNGWORAKAN Tichar , MANEEDANG Noppadol , CHAROENPANİCH Nongnapas
Published: January 2024

The characteristics of Manohra dance are delicate because of the high physical performance specific posture, which can communicate the meaning. The purpose of this study is to study the effects of exercise with Manohra dance on physical performance, which were postural balance, muscle strength, and flexibility. Twenty-four female students aged 12-13 years old were included in the training program. They were randomly divided into two groups, experimental and control groups, twelve in each group. All subjects were trained with a strength and flexibility program as circuit training, only the experimental group was additionally trained with eight specific postures of the Manohra dance. All subjects were performed 3 times a week for 8 weeks continuously. The study involved three testing sessions pre-training, after 4-weeks and 8-weeks intervention. Compared between groups by using an independent t-test, significant at p<0.05. The results of experimental group showed higher significant difference in postural balance in all directions during the performance of YBT (p<0.05; YBT 1 p=0.044, YBT 2 p=0.004 and YBT 3 p=0.017) and flexibility (p<0.05; p=0.047) than the control group at week 8th. While there was no significant difference between groups of leg muscle strength (p>0.05). As a result, it was determined that the Manohra dance shows advantages, which are charming, conservation, and good for health, it can be suggested to use the Manohra dance posture in a training program to improve postural balance and flexibility in children.
Gençlik ve Spor Bakanlığı Gençlik Kamplarında Görev Yapan Kamp Liderlerinin Bazı Demografik Değişkenlere Göre Liderlik Becerilerinin İncelenmesi
Authors: Şahin Medine , Bezci Şakir
Published: January 2024

Bu çalışmada, Gençlik ve Spor Bakanlığı Gençlik Kamplarında görev yapan kamp liderlerinin bazı demografik değişkenlere göre liderlik becerileri incelenmiştir. Veri toplama aracı olarak, Gençlik Liderlik Özellikleri Ölçeği ve araştırmacı tarafından hazırlanan demografik bilgi formu kullanılmıştır. Elde edilen verilere göre, cinsiyet değişkenine göre liderlik, iletişim kurabilme, grup becerileri, güven duyma ve güvenilir olma, karar verme becerileri, problem çözme becerileri, sorumluluk puanları arasında anlamlı bir farklılık olmadığı; mücadele isteği ve hedef koyma puanları arasında anlamlı bir farklılık gözlenmiş olup erkeklerin kadınlara kıyasla mücadele isteği ve hedef koyma puanı daha yüksek bulunmuştur. Yaş değişkenine bakıldığı zaman liderlik, mücadele isteği ve hedef koyma, iletişim kurabilme, grup becerileri, güven duyma ve güvenilir olma, sorumluluk puanları arasında anlamlı bir ilişki olmadığı; karar verme becerileri, problem çözme becerileri puanları arasında ters yönde çok zayıf düzeyde anlamlı bir ilişki olduğu tespit edilmiştir. Eğitim durumuna göre liderlik, mücadele isteği ve hedef koyma, iletişim kurabilme, grup becerileri, güven duyma ve güvenilir olma, karar verme becerileri, problem çözme becerileri, sorumluluk puanları arasında anlamlı bir farklılık olmadığı gözlenmiştir. Meslekteki çalışma sürelerine göre liderlik, mücadele isteği ve hedef koyma, iletişim kurabilme, grup becerileri, güven duyma ve güvenilir olma, problem çözme becerileri, sorumluluk puanları arasında anlamlı bir farklılık olmadığı; karar verme beceri puanları arasında anlamlı bir farklılık gözlenmiştir. Kamp liderliği yapma sürelerine göre liderlik, mücadele isteği ve hedef koyma, iletişim kurabilme, grup becerileri, güven duyma ve güvenilir olma, karar verme beceri, problem çözme becerileri, sorumluluk puanları arasında anlamlı bir farklılık olmadığı gözlenmiştir. Sonuç olarak araştırma grubunun liderlik becerilerin yüksek düzeyde olduğu görülmüştür.
Efektivitas Perencanaan Anggaran dalam Sistem Informasi Pemerintahan Daerah (SIPD) di Kabupaten Gresik Provinsi Jawa Timur
Authors: Tumija Tumija , Ramadhan Akhmad Zakky
Published: January 2024

Kabupaten Gresik memiliki kemampuan menerapkan Good Governance melalui Sistem Pemerintahan Berbasis Elektronik (SPBE) khususnya dalam tata kelola keuangan daerah dimana penerapan Sistem Informasi Pemerintahan Daerah (SIPD) menjadi kunci kesuksesan E-government. Penelitian ini bertujuan mengetahui efektivitas perencanaan anggaran, dan  faktor penghambat dalam SIPD di Kabupaten Gresik.

Penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan induktif, karena penulis melakukan pengamatan terlebih dahulu terhadap permasalahan kemudian melakukan penarikan kesimpulan yang berasal dari kegiatan wawancara, observasi dan dokumentasi.

Hasil penelitian menunjukkan bahwa dalam perencanaan anggaran dalam SIPD sudah efektif. Hal ini ditunjukkan dari enam dimensi efektivitas perencanaan menurut Handoko, (2003:103). Pertama, dimensi Kegunaan, SIPD sudah efektif dalam layanan sarana informasi yang terintegrasi antara pemerintah pusat dan daerah. Kedua, dimensi ketepatan dan objektivitas, bahwa SIPD menciptakan keakuratan dalam perencanaan anggaran. Ketiga, dilihat dari dimensi ruang lingkup bahwa SIPD telah sesuai dengan prioritas yang dibutuhkan dalam tahapan-tahapan penyusunan perencanaan anggaran. Keempat, dimensi efektivitas biaya, bahwa sistem ini kedepannya tidak memerlukan biaya dalam penerapannya  sehingga efisien dari segi biaya. Kelima, dimensi Akuntabilitas, dengan adanya aplikai ini input data tepat waktu dalam perencanaan sampai dengan cetak data. Keenam, dimenai ketepatan waktu  bahwa aplikasi ini realtime dimana verifikasi input data oleh OPD atas kegiatan dalam satu tahun. Hambatan perencanaan dalam SIPD ini yaitu keterlambatan OPD dalam penginputan SIPD, dokumen fisik penyusunan perencanaan anggaran terlalu tebal, tidak memiliki hak akses untuk merubah dan menetapkan kegiatan dan verifikasi TAPD yang membutuhkan waktu lama
Analisis Mekanisme Tabungan Berencana Menggunakan Akad Mudharabah Mutalaqah Pada PT. Bank Sumut Syariah Medan
Authors: Sari Widya Purnama , Arafah Santi
Published: January 2024

Penelitian ini bertujuan untuk mengetahui tabungan berencana yang digunakan oleh Bank Sumut Syariah Medan dalam tabungan berencana akad mudharabah mutlaqah. Jenis penelitian yang digunakan adalah kualitatif, sedangkan sifat penelitian yaitu deskriptif. Teknik pengumpulan data yang dilakukan yaitu wawancara, observasi dan dokumentasi. Temuan penelitian menunjukkan bahwa Bank Sumut Syariah Medan bermaksud untuk menerapkan Perjanjian Mudharabah Mutlaqah dalam analisisnya tentang mekanisme tabungan. Kontrak mudharabah mutalaqah yang dimaksudkan untuk dimanfaatkan dengan mekanisme tabungan. Karena Bank Sumut Syariah Medan menganut prinsip syariah, setiap bank harus menggunakan akad yang melakukan hal yang sama sebagai dasar suatu produk agar dapat menawarkan salah satu fasilitas kepada nasabah. Tantangan Bank Sumut Syariah Medan yaitu kemungkinan finalty jika nasabah menarik uang sebelum perjanjian awal
Upper Limits for Velocity, Momentum, and Energy of Motion
Authors: Annamalai Chinnaraji
Published: January 2024

The velocity of a moving object with its non-zero mass or a moving particle with its non-zero mass is less than the speed of light because light has no mass. So, the speed of light is the upper limit for all moving objects in the Universe. In this article, the upper limits for momentum and energy of motion are derived for scientific problem-solving.
E SE VOCÊ FOR ARTISTA MAGO(A)?
Authors: Guerra Nadam
Published: January 2024

Neste texto, propomos o conceito de artista mago. Buscamos definições de Magia e a estrutura do xamanismo para traçar pontos de contato entre Arte e Magia. Listamos exemplos de artistas (1) que são ligados a tradições mágicas ou que utilizam elementos destas tradições; (2) de artistas que têm práticas análogas à magia mesmo não sendo ligados a nenhuma tradição; e (3) de artistas magos propriamente que, conscientemente, utilizam procedimentos mágicos ou análogos em sua obra construindo uma espiritualidade criativa. Com estas aproximações pretendemos demonstrar que toda arte pode ser vista como uma espécie de magia.
CONTAMINAÇÕES MÁGICAS
Authors: Desideri Marcio Ricardo Desideri
Published: January 2024

Através da linguagem da maquiagem nas artes da cena contemporânea, investigamos as “contaminações mágicas” no ator, que se constituem de (in)corporações, de acordo com a teoria do corpomídia, de Elena Katz e Cristina Greiner. Para que dessa maneira, pudéssemos ultrapassar as implicações reducionistas e escassez de teorias acerca da maquiagem nas artes cênicas, além das técnicas. Dado que foi possível consideramos a maquiagem como um parasita com variados níveis de contaminações ao corpo, seja animado ou inanimado. Bem como proposta inovadora de a compreender como uma linguagem visual artística híbrida “polifônica”, de acordo com o estudo de polifonia de Ernani Maletta, das quais as personas plásticas se proliferam e reverberam suas vozes, revelando complexas camadas que constitui a virtualidade e a materialidade, entre conceitos do atual, do possível e da memória. Contudo, sob a ótica do esoterismo, direcionamos os processos de (in)corporações e relacionamos suas origens, os símbolos, os rituais, as máscaras e os objetos com o arcaico na contemporaneidade. Na qual concluímos com os desdobramentos dessa conjuntura, as multiplicidades que atravessam o corpo, bem como as tensões com a máscara e a maquiagem, as camadas holográficas e o outro que habita o ator no processo de contaminação
AYAUHUAYA
Authors: Silva Matheus Moura
Published: January 2024

Este artigo tem como foco o processo criativo de uma história em quadrinhos a partir do uso de ayahuasca. A história em questão se chama, AyauhuayA, e foi escolhida para este trabalho por se tratar de um encontro com um ser espiritual durante transe psicodélico. Na introdução do artigo é dado o panorama da pesquisa, realizada no contexto da tese defendida em 2018, no PPGACV/FAV-UFG. São descritos os capítulos que a compõe e levantados pontos como: as perguntas motivadoras para a pesquisa, 1) Há diferença entre o ímpeto criador do que é feito de modo ordinário em contraposição ao visionário?; 2) O que diferencia os quadrinhos visionários dos realizados de modo ordinário?. E a metodologia empregada, sendo esta a pesquisa baseada em arte, a autoetnografia e a bricolagem. A experiência em si é o mote da história em quadrinhos que busca retratar, o mais próximo possível, a visão original. Sendo a HQ um trabalho criado colaborativamente no escopo da Arte Visionária. No decorrer do texto é feita a descrição do processo criativo, desde a obtenção da visão, criação do roteiro ao desenho final. Com base em pesquisas sobre criatividade e ENOC, além da experiência empírica com criação visionária, concluir que, primeiro, não existem diferenças entre o ímpeto criador ordinário e o visionário. Segundo, a diferenciação entre os quadrinhos visionários e ordinários seria apenas a percepção do autor de que aquela narrativa é, na verdade, a expressão de uma realidade distinta e não uma criação pura e simples do intelecto imaginativo.
Composition of “Karma” based on the Gestalt Modeling of “Ponteio No. 29” by Camargo Guarnieri
Authors: Alves de Oliveira Helder , Pitombeira Liduino
Published: January 2024

This work consists of two parts, the first being the analysis of “Ponteio No. 29”, by Camargo Guarnieri, based on the methodology called Gestalt Modeling (hereinafter GM). The analysis was carried out from the perspective of Gestalt Theory based on two laws of perceptual organization. It aimed to stipulate the general guidelines for the hypothetical system that created that work by Guarnieri and, finally, to generate subsidies for the planning of a new composition using this same compositional system. The compositional planning of the new work consists of the second part of this paper. The final conclusions indicate that GM is: 1) a useful and distinctive resource for the analysis of musical works and composition, as it coherently presents new ways of organizing musical elements; and 2) a possible methodology for compositional pedagogy, as it provides subsidies for a conscious practice and the development of students’ own compositional language.
Gram-negative bacterial sRNAs encapsulated in OMVs: an emerging class of therapeutic targets in diseases
Authors: Ajam-Hosseini Mobarakeh , Akhoondi Fatemeh , Parvini Farshid , Fahimi Hossein
Published: January 2024

Small regulatory RNAs (sRNAs) encapsulated in outer membrane vesicles (OMVs) are critical post-transcriptional regulators of gene expression in prokaryotic and eukaryotic organisms. OMVs are small spherical structures released by Gram-negative bacteria that serve as important vehicles for intercellular communication and can also play an important role in bacterial virulence and host-pathogen interactions. These molecules can interact with mRNAs or proteins and affect various cellular functions and physiological processes in the producing bacteria. This review aims to provide insight into the current understanding of sRNA localization to OMVs in Gram-negative bacteria and highlights the identification, characterization and functional implications of these encapsulated sRNAs. By examining the research gaps in this field, we aim to inspire further exploration and progress in investigating the potential therapeutic applications of OMV-encapsulated sRNAs in various diseases.
MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection
Authors: De Mithu , Serpa Gregory , Zuiker Eryn , Hisert Katherine B. , Liles W. Conrad , Manicone Anne M. , Hemann Emily A. , Long Matthew E.
Published: January 2024

Chronic pulmonary bacterial infections and associated inflammation remain a cause of morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator therapies. Therapies targeting host factors that dampen detrimental inflammation without suppressing immune responses critical for controlling infections remain limited, while the development of lung infections caused by antimicrobial resistant bacteria is an increasing global problem, and a significant challenge in CF. Pharmacological compounds targeting the mammalian MAPK proteins MEK1 and MEK2, referred to as MEK1/2 inhibitor compounds, have potential combined anti-microbial and anti-inflammatory effects. Here we examined the immunomodulatory properties of MEK1/2 inhibitor compounds PD0325901, trametinib, and CI-1040 on CF innate immune cells. Human CF macrophage and neutrophil phagocytic functions were assessed by quantifying phagocytosis of serum opsonized pHrodo red E. coli, Staphylococcus aureus, and zymosan bioparticles. MEK1/2 inhibitor compounds reduced CF macrophage pro-inflammatory cytokine production without impairing CF macrophage or neutrophil phagocytic abilities. Wild-type C57BL6/J and Cftrtm1kth (F508del homozygous) mice were used to evaluate the in vivo therapeutic potential of PD0325901 compared to vehicle treatment in an intranasal methicillin-resistant Staphylococcus aureus (MRSA) infection with the community-acquired MRSA strain USA300. In both wild-type and CF mice, PD0325901 reduced inflammation associated body mass loss. Wild-type mice treated with PD0325901 had significant reduction in neutrophil-mediated inflammation compared to vehicle treatment groups, with preserved clearance of bacteria in lung, liver, or spleen 1 day after infection in either wild-type or CF mouse models. In summary, this study provides the first data evaluating the therapeutic potential of MEK1/2 inhibitor to modulate CF immune cells and demonstrates that MEK1/2 inhibitors diminish pro-inflammatory responses without impairing host defense mechanisms required for acute pathogen clearance.
Translating, transmitting and transforming Waldorf curricula: one hundred years after the first published curriculum in 1925
Authors: Rawson Martyn
Published: January 2024

The first Waldorf School was founded in 1919 and the first curriculum was published in German in 1925. Since then, this curriculum has been translated into many other languages and transmitted across geographical space to other cultural contexts while maintaining the character of Steiner Waldorf education. For much of the past 100 years it has been a taken-for-granted source of inspiration for Waldorf teachers. However, Waldorf education faces a number of challenges to its curriculum. In many countries it is increasingly forced to explain and justify itself to the state and comply with educational policy requirements for standardisation and testing. It is challenged to adapt to the digital age and it faces calls to modify its original Western focus and become more attuned to local cultures, while retaining its universal humanist aspirations and its intrinsic character and function. Given that the curriculum is one of the best-known features of Waldorf education, it is surprising that there has been so little research on it. Drawing on the relevant literature, this review paper explores the fundamental concepts of curriculum within Waldorf education: its primary characteristics and functions. It tracks the historical development and the way the curriculum has been adapted both to requirements within schools and to external factors. Along the way there have been differing understandings of the status and function of the curriculum, including whether and in what sense it is universal and essentially unchangeable and/or how it can be adapted. This paper highlights a number of areas in which further research is needed and reports on important new developments, which promise to sustain the viability and relevance of the Waldorf curricula.
Advancing teacher reflective competence: integrating lesson study and didactic suitability criteria in training
Authors: Hummes Viviane , Seckel Maria José
Published: January 2024

This study examines the impact of combining Lesson Study and the Didactic Suitability Criteria (DSC) for the development of teacher reflective skills. It involves six teachers in an Argentinean training program, spanning 15 virtual sessions over 5 months. Analysis of video recordings indicates significant improvement in reflective abilities, especially when using the DSC for lesson analysis. This approach enhances teaching quality and benefits student learning. The study suggests Lesson Study and the DSC are valuable tools for promoting collaboration and reflection among educators, particularly in math education. Further research with larger samples and long-term follow-up is recommended. This underscores the importance of integrating Lesson Study and the DSC in teacher training to enhance reflective competence and raise education quality.
Accuracy of the 10 μg desmopressin test for differential diagnosis of Cushing syndrome: a systematic review and meta-analysis
Authors: Giampietro Rodrigo Rosa , Cabral Marcos Vinicius Gama , Pereira Elizandra Gomes , Machado Marcio Carlos , Vilar Lucio , Nunes-Nogueira Vania dos Santos
Published: January 2024

We evaluated the accuracy of the 10 μg desmopressin test in differentiating Cushing disease (CD) from non-neoplastic hypercortisolism (NNH) and ectopic ACTH syndrome (EAS). A systematic review of studies on diagnostic test accuracy in patients with CD, NNH, or EAS subjected to the desmopressin test obtained from LILACS, PubMed, EMBASE, and CENTRAL databases was performed. Two reviewers independently selected the studies, assessed the risk of bias, and extracted the data. Hierarchical and bivariate models on Stata software were used for meta-analytical summaries. The certainty of evidence was measured using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation Working Group) approach. In total, 14 studies were included: 3 studies on differentiated CD versus NNH and 11 studies on differentiated CD versus EAS. Considering ΔACTH in 8 studies involving 429 patients, the pooled sensitivity for distinguishing CD from EAS was 0.85 (95% confidence interval [CI]: 0.80–0.89, I2 = 17.6%) and specificity was 0.64 (95% CI: 0.49–0.76, I2 = 9.46%). Regarding Δcortisol in 6 studies involving 233 participants, the sensitivity for distinguishing CD from EAS was 0.81 (95% CI: 0.74–0.87, I2 = 7.98%) and specificity was 0.80 (95% CI: 0.61–0.91, I2 = 12.89%). The sensitivity and specificity of the combination of ΔACTH > 35% and Δcortisol > 20% in 5 studies involving 511 participants were 0.88 (95% CI: 0.79–0.93, I2 = 35%) and 0.74 (95% CI: 0.55–0.87, I2 = 27%), respectively. The pooled sensitivity for distinguishing CD from NNH in 3 studies involving 170 participants was 0.88 (95% CI: 0.79–0.93) and the specificity was 0.94 (95% CI: 0.86–0.97). Based on the desmopressin test for differentiating CD from EAS, considering ΔACTH, Δcortisol, or both percent increments, 15%, 19%, or 20% of patients with CD, respectively, would be incorrectly classified as having EAS. For CD versus NNH, 11% of patients with CD would be falsely diagnosed as having NNH, whereas 7% of patients with NNH would be falsely diagnosed as having CD. However, in all hierarchical plots, the prediction intervals were considerably wider than the confidence intervals. This indicates low confidence in the estimated accuracy, and the true accuracy is likely to be different.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=85634, identifier CRD42018085634; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=68317, identifier CRD42017068317.
The combination of IL-2 nanoparticles and Palbociclib enhances the anti-tumor immune response for colon cancer therapy
Authors: Wang Di , Wang Xiaoshuang , Zhang Yingyu , Yu Le , An Jing , Wang Xiaodong , Huang Yue , Han Xuemei
Published: January 2024

Immunotherapy of tumors plays a pivotal role in the current treatment of cancer. While interleukin 2 (IL-2) demonstrated its efficacy as an immunotherapeutic drug in the early days, its short blood circulation time poses challenges in maintaining effective therapeutic concentrations. Additionally, IL-2’s activation of regulatory T cells can counteract its anti-cancer effects. Therefore, the primary goal of this study was to formulate IL-2-carrying nanoparticles via boron-nitrogen coordination between methoxy poly (ethylene glycol) block poly-[(N-2-hydroxyethyl)-aspartamide]phenylboronic acid (mPEG-b-PHEA-PBA, P-PBA) and poly (L-lysine) (PLL). These nanoparticles are intended to be used in combination with CDK4/6 inhibitors to address the short blood circulation time of IL-2, reduce its immunosuppressive effects, and enhance the overall immune response. The envisaged outcome is a sustained and potent therapeutic effect, offering a novel and promising combination therapy strategy for tumor immunotherapy.
Serum immunoglobulin or albumin binding single-domain antibodies that enable tailored half-life extension of biologics in multiple animal species
Authors: Harmsen Michiel M. , Ackerschott Bart , de Smit Hans
Published: January 2024

Single-domain antibody fragments (sdAbs) can be isolated from heavy-chain-only antibodies that occur in camelids or the heavy chain of conventional antibodies, that also occur in camelids. Therapeutic application of sdAbs is often complicated by their low serum half-life. Fusion to sdAb that bind to long-lived serum proteins albumin or IgG can prolong serum half-life of fusion partners. Such studies mostly focused on human application. For half-life prolongation in multiple animal species novel species cross-reacting sdAb are needed. We here describe the isolation from immunized llamas of sdAbs G6 and G13 that bound IgG of 9-10 species analysed, including horse, dog, cat, and swine, as well as sdAb A12 that bound horse, dog, swine and cat albumin. A12 bound albumin with 13 to 271 nM affinity dependent on the species. G13 affinity was difficult to determine by biolayer interferometry due to low and heterogeneous signals. G13 and G6 compete for the same binding domain on Fab fragments. Furthermore, they both lack the hallmark residues typical of camelid sdAbs derived from heavy-chain antibodies and had sequence characteristics typical of human sdAbs with high solubility and stability. This suggests they are derived from conventional llama antibodies. They most likely bind IgG through pairing with VL domains at the VH-VL interface rather than a paratope involving complementarity determining regions. None of the isolated sdAb interfered with FcRn binding to albumin or IgG, and thus do not prevent endosomal albumin/IgG-sdAb complex recycling. Fusions of albumin-binding sdAb A12 to several tetanus neurotoxin (TeNT) binding sdAbs prolonged the terminal serum half-life in piglets to about 4 days, comparable to authentic swine albumin. However, G13 conferred a much lower half-life of 0.84 days. Similarly, in horse, G13 prolonged half-life to only 1.2 days whereas A12 fused to two TeNT binding domains (T6T16A12) had a half-life of 21 days. The high half-life of T6T16A12, which earlier proved to be a highly potent TeNT antitoxin, further supports its therapeutic value. Furthermore, we have identified several additional sdAbs that enable tailored half-life extension of biologicals in multiple animal species.
Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
Authors: Marmelo Isa , Dias Marta , Grade Ana , Pousão-Ferreira Pedro , Diniz Mário Sousa , Marques António , Maulvault Ana Luísa
Published: January 2024

The increasing demand for healthy aquatic products has contributed to the rapid growth of aquaculture. Despite the many progresses, over the years, in aquaculture production, animal welfare and reduction of the stress induced by captivity remain a challenge in this sector, and overcoming it is fundamental to improve animal growth performance and resilience to environmental threats (e.g., disease outbreaks and/or climate change impacts). To address this challenge, aquafeeds biofortified with natural ingredients with functional properties, such as macroalgae, have emerged as a promising strategy to enhance fish immunity. The present study aimed at evaluating the potential of Laminaria digitata to improve juvenile gilthead seabream (Sparus aurata) physiological status and resilience, through the modulation of immunomodulatory and antioxidant responses. To explore this hypothesis, four independent treatments were carried out in which fish were fed with different experimental aquafeeds: control feed and biofortified feeds with 1.5%, 3% and 6% of whole L. digitata (incorporated as a dried and powdered ingredient). Fish (n=9) were collected from each treatment upon 30 and 60 days of biofortification in order to assess animal growth and condition indexes, haematological parameters, innate humoral parameters (antiprotease (AP) activity, peroxidase (POD) activity and immunoglobulin M (IgM)) and oxidative stress biomarkers (lipid peroxidation (LPO), catalase (CAT) activity, glutathione S-transferase (GST) activity, superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC)). Significant differences (α = 0.05) between treatments in biomarker responses were tested through a nested-design ANOVA, followed by Tukey HSD multiple comparisons. Pearson correlations between the different endpoints were also explored. Results indicate that a dietary inclusion of 1.5% L. digitata is the most effective biofortification dose, significantly improving antioxidant responses of S. aurata, by increasing levels of CAT, GST and T-AOC, along with the reduction in LPO levels. Additionally, the inclusion of 1.5% L. digitata enhances immunity by increasing the levels of IgM and POD, while maintaining the growth performance and condition indices of the fish. These findings underscore the potential utilization of L. digitata as a functional feed ingredient in aquaculture with relevant immune and antioxidant attributes.
Research in the application of artificial intelligence to lung cancer diagnosis
Authors: Liu Wenjuan , Shen Nan , Zhang Limin , Wang Xiaoxi , Chen Bainan , Liu Zhuo , Yang Chao
Published: January 2024

The morbidity and mortality rates in lung cancer are high worldwide. Early diagnosis and personalized treatment are important to manage this public health issue. In recent years, artificial intelligence (AI) has played increasingly important roles in early screening, auxiliary diagnosis, and prognostic assessment. AI uses algorithms to extract quantitative feature information from high-volume and high-latitude data and learn existing data to predict disease outcomes. In this review, we describe the current uses of AI in lung cancer-focused pathomics, imageomics, and genomics applications.
Evaluation of serum neurofilament light chain and glial fibrillary acidic protein in the diagnosis of Alzheimer’s disease
Authors: Fang Tangni , Dai Yaqian , Hu Xueyi , Xu Yuanhong , Qiao Jinping
Published: January 2024

Purpose

This study aimed to evaluate the use of serum neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in the diagnosis of Alzheimer’s disease (AD) and the differential diagnosis between AD and mild cognitive impairment (MCI).

Methods

From September 2021 to October 2022, we collected venous blood from patients and healthy individuals who visited our hospital’s Neurology Department, and we isolated serum to detect NfL and GFAP using direct chemiluminescence. The results were analyzed using one-way analysis of variance (ANOVA) analysis and receiver operating characteristic (ROC) curves.

Results

Pairwise comparisons among the three groups showed that compared with the health checkup (HC) group, serum NfL and GFAP were increased in both AD and MCI (PNfL < 0.05, PGFAP < 0.01). There were significant differences in GFAP between MCI and AD groups, and the level in AD group was higher (p < 0.01), while there was no difference in NfL. Both serum NfL and serum GFAP levels can independently diagnose AD (p < 0.01). The ROC curve showed that GFAP had a higher diagnostic efficacy, with an area under the ROC curve (AUC) of 0.928. The cut-off values of the two serum markers for the diagnosis of AD were NfL > 40.09 pg./mL and GFAP >31.40 pg./mL. Sensitivity and specificity for NfL in the diagnosis of AD were 59.6 and 76.2%, respectively, and for GFAP, they were 90.4 and 82.1%, respectively. The combined diagnosis of GFAP and NfL improved the diagnostic efficiency (AUC = 0.931, sensitivity = 78.8%, specificity = 92.3%). The cut-off value of GFAP for the differential diagnosis of MCI and AD was 46.05 pg./mL.

Conclusion

Both serum NfL and serum GFAP can be used as biomarkers for the diagnosis of AD. Serum GFAP has better diagnostic efficacy and can distinguish AD from MCI. A combined diagnosis can improve diagnostic specificity.