bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolutionary aspects of bipolar affective illness
Authors: Rybakowski Janusz , Rybakowski Filip
Published: December 2023

Choroba afektywna dwubiegunowa (ChAD) zwana również chorobą maniakalno-depresyjną charakteryzuje się okresowym występowaniem biegunowo przeciwnych stanów nastroju, aktywności i motywacji do działania (manii i depresji) niekiedy o ekstremalnym nasileniu. Wytworzenie takich stanów i ich utrzymywanie się w procesie ewolucji może świadczyć o możliwości ich adaptacyjnego charakteru umożliwiającego przystosowanie do niekorzystnej sytuacji zewnętrznej (depresja) oraz mobilizację organizmu w obliczu dostępności zasobów (mania). W artykule główny nacisk jest położony na ewolucyjny aspekt „dwubiegunowości” oraz stanów maniakalnych i hipomaniakalnych. Badania genetyczno-molekularne wskazują, że w przebiegu ewolucji doszło do zachowania genów związanych z predyspozycją do ChAD. W pracy omówiono ewolucyjne koncepcje adaptacyjne ChAD, związane z funkcjonowaniem Homo sapiens w okresie środkowego i późnego plejstocenu, jak również koncepcje „mismatch” związane z nieprzystawalnością czynności mózgu do współczesnych warunków. Przedstawiono ewolucyjne korzyści stanu manii/hipomanii, również w kontekście ich powiązania ze stanami depresji, wskazujące na możliwość związku ze zwiększeniem sukcesu reprodukcyjnego. Jest on następstwem takich cech stanu maniakalnego/hipomaniakalnego, jak zwiększona aktywność eksploracyjna, psychoruchowa i seksualna oraz łatwe podejmowanie ryzyka. Sukces reprodukcyjny może też wiązać się z temperamentem hipertymicznym i cyklotymicznym najczęściej występującymi w ChAD, jako że temperament hipertymiczny często doprowadza do podwyższenia statusu społecznego i tendencji do przywództwa, a temperament cyklotymiczny może zwiększać kreatywność. Przytoczone są przykłady związku między stanem maniakalnym/hipomaniakalnym a zjawiskiem emigracji oraz wpływem na rozwój społeczeństwa amerykańskiego.
The place of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depressive disorders in children and adolescents. Recommendations of the Main Board of the Polish Psychiatric Association. Part 2 – pharmacological properties and safety of use
Authors: Janas-Kozik Małgorzata Honorata , Słopień Agnieszka , Remberk Barbara , Siwek Marcin
Published: December 2023

Celem pracy było dokonanie przeglądu badań oceniających właściwości farmakodynamiczne selektywnych inhibitorów wychwytu zwrotnego serotoniny (SSRI), jak i bezpieczeństwa ich stosowania. SSRI u pacjentów <18r.ż. odznaczają się niekiedy odmiennością parametrów farmakokinetycznych w porównaniu do osób dorosłych, co ma istotny pływ na ich skuteczność i tolerancję. Stężenie fluoksetyny, fluwoksaminy czy paroksetyny jest około 2x większe u dzieci w porównaniu do młodzieży i dorosłych co powinno być uwzględnione na etapie zarówno wprowadzania leku jak i ustalania dawek docelowych. W przypadku istotnych problemów z doborem leku i/lub dawki leku w związku z niezadowalającą skutecznością i/lub tolerancją u pacjenta <18r.ż. bardzo istotne znaczenie może mieć zbadanie polimorfizmu dominującego dla metabolizmu danego leku izoenzymu, dotyczy to zwłaszcza CYP2C19 w przypadku leczenia escitalopramem, a w mniejszym stopniu w trakcie leczenia sertraliną oraz CYP2D6 w przypadku stosowania fluoksetyny lub paroksetyny. Leki z grupy SSRI są na ogół dobrze tolerowane u pacjentów w wieku poniżej18 r.ż. a większość działań niepożądanych (TEAE) w trakcie leczenia ma nasilenie łagodne lub umiarkowane. W większości RCT oceniających skuteczność SSRI w leczeniu depresji u pacjentów w wieku <18r.ż. wskaźniki nasilenia lub wystąpienia myśli samobójczych w trakcie obserwacji są porównywalne do placebo, próby samobójcze są zjawiskiem rzadkim, a pojedyncze przypadki, występują tak w grupach aktywnego leczenia jak i w ramieniu placebo.
Nie wykazano istotnie statystycznie zwiększonego ryzyka dla LPD (w tym wszystkich SSRI) lub psychoterapii czy też kombinacji LPD z psychoterapią (poza wenlafaksyną). Jedynie terapia wenlafaksyną wiązała się ze zwiększonym w porównaniu do placebo ryzykiem wystąpienia zachowań i/lub ideacji samobójczych w terapii krótkoterminowej.
Short Communication: Ethnobotanical study of medicinal plants used to treat livestock ailments in Dallo Manna District, Oromia State, Ethiopia
Authors: GOBANA AWAL HUSSIEN , TELILA HABTE , Jilo Sufian Abdo
Published: December 2023

Abstract. Gobana AH, Telila H, Jilo SA. 2023. Short Communication: Ethnobotanical study of medicinal plants used to treat livestock ailments in Dallo Manna District, Oromia State, Ethiopia. Asian J Ethnobiol 6: 127-136. Historical information on the use of medicinal plants is in danger of extinction due to changes in different parts of the world, including Ethiopia. This study aimed at the ethnobotanical analysis of medicinal plants used to treat animal diseases. Data were collected through semi-structured interviews with the selected informant sources. Analysis of ethnobotanical data used the Informant Consensus Factor (ICF), preference ranking, ranking matrix, and calculating the degree of fidelity. Dallo Manna Region was reported to have all 68 medicinal plant species used to treat veterinary diseases. The most common family is Fabaceae (7 spp.), followed by Euphorbiaceae (5 spp.), Asteraceae (5 spp.), and Solanaceae (4 spp.). The local people generally used the root, followed by leaves, seeds, and stems, to prepare drugs for treating livestock diseases. All medicine is made and used immediately; some are boiled and dried. In addition, the most common route of administration for treating animal diseases in the study area is oral, followed by topical application and nasal. The highest consensus criteria (ICF) values were recorded in ophthalmology, followed by dermatology. Most species have been reported for treating gastrointestinal disorders, followed by species for treating skin diseases and fever. Ten participants compared nine herbs used to treat veterinary diseases to determine their rankings. Hagenia abyssinica (Bruce) J.F.Gmel. in the first place, then this was followed by Zingiber officinale Roscoe and Embelia schimperi Vatke in third place, which achieved the highest value among traditional medicinal plants. The main threats to veterinary medicinal plants are overharvesting of available species, agricultural land expansion, and less attention to traditional medicine due to modernization.
Ethnobotanical study of medicinal plants in Ogotun-Ekiti, Ekiti State, Nigeria
Authors: KILASHO ADEOLA , KOLADE MOLAWA ABDULLAHI , OLUBORODE JAMES , JACKSON VINCENT , AFOLABI SAMUEL
Published: December 2023

Abstract. Kilasho A, Kolade MA, Oluborode J, Jackson V, Afolabi S. 2023. Ethnobotanical study of medicinal plants in Ogotun-Ekiti, Ekiti State, Nigeria. Asian J Ethnobiol 6: 138-144. The essential role of medicinal plants in maintaining human health demonstrates the necessity for appropriate knowledge and documentation of their significance and application. The aim of this study is to thoroughly and methodically record the ethnobotanical knowledge of medicinal plants by local community in Ogotun-Ekiti, Nigeria. The data was collected using both interview method and a structured questionnaire. Respondents were chosen based on their experience, related job and deep understanding of the usage of herbal medicines. According to the findings of the research, 81 medicinal plant species from 40 families and 78 genera were identified and documented. The study also revealed that trees make up 58% of all plants, shrubs make up 27%, herbs make up to 10%. Furthermore, leaves (57%) were the most plant parts used in treating several ailments followed by bark (21%), root (10%) and the seeds (8%) as the least used plant parts. Plants from the Malvaceae family (9 species) were recorded to be the most available in the study area, followed by the Fabaceae family (7 species), Moraceae and Asteraceae (each with 5 species) and three species each from Anarcadiaceae, Combreteaceae, Poaceae, Sapotaceae, Curcurbiataceae, Rutaceae, Solanaceae and Lamiaceae. Some of the frequent illnesses treated with medicinal plants in the study region include: malaria, urinary tract infection, diarrhoea, diabetes amongst others. This study concluded that ethnobotanical survey is crucial for assessing current knowledge and serving as a baseline for future analyses of changes in knowledge and usage. These will thereby give the use of medicinal plants more national and global recognition.
Short Communication: Ethnobotanical survey of medicinal plants for wound healing in Dir Upper District, Pakistan
Authors: JAWADULLAH JAWADULLAH , AKHTAR NAVEED
Published: December 2023

Abstract. Jawadullah, Akhtar N. 2023. Short Communication: Ethnobotanical survey of medicinal plants for wound-healing in Dir Upper District, Pakistan. Asian J Ethnobiol 6: 145-152. Medicinal plants have been used since ancient time by the communities as an alternative to the synthetic medicine, which have adverse side effects and is not available to every individual. This study reports medicinal plants used for wound-healing by the local peoples in Dir Upper District, northern area of Pakistan. A semi-structured questionnaire was used to collect ethnomedicinal data by interviewing 50 informants of different ages (25 to 90 years old). Plant samples were collected as herbarium to be identified in the laboratory. The result shows a total of 20 plant species, each belonging to different families, were used for wound-healing. The majority of growth forms of such plants were herbs (35%) and trees (35%), followed by shrubs (25%) and climbers (5%). The plant parts used for healing were leaves of the plant (45%), followed by plant bark (10%), whole plant (10%), plant roots (10%), fruit peel (5%), gum (5%), bulb (5%), rhizome (5%) and latex (5%). Furthermore, external applications were more common than oral consumption to promote wound-healing. Berberis lycium Royle, Curcuma longa L. and Punica protopunica Balf.fil. were the most cited species used to heal wounds. This study revealed that there is an array of plant biodiversity among Pakistanis for the purpose of wound-healing. This is a result of the socioeconomic status and limited access to modern health services and their preference for folk medicine. Further studies should be planned to create an online database for a collection of therapeutic medicinal plants and their traditional healing potentials.
Species diversity of socio-economic importance in the Kebe Block Forest, Cameroon: Local perceptions and conservation implications
Authors: INIMBOCK SOREL LEOCADIE , CHIMI CÉDRIC DJOMO , NGOMENI ARLENDE FLORE , ENAMBA CHRISTIAN YAYA , POUOMOGNE YOLLANDE GUIAWA , CASPA ROSE GUSUA , TSEMO DIANE CHRISTELLE , NGUEGUIM ELVIS CHENANG , YONGA GUILLAINE , NOUTANEWO PANY , MISSE CHRISTIAN ALAIN , MALA WILLIAM ALAIN
Published: December 2023

Abstract. Inimbock SL, Chimi CD, Ngomeni AF, Enamba CY, Pouomogne YG, Caspa RG, Tsemo DC, Ngueguim EC, Yonga G, Noutanewo P, Misse CA, Mala WA. 2023. Species diversity of socio-economic importance in the Kebe Block Forest, Cameroon: Local perceptions and conservation implications. Asian J Ethnobiol 6: 155-162. Forest areas dedicated to research and education, such as the Kebe Block Forest (KBF), Cameroon, have a high plant diversity, some of which are of socio-economic importance to local populations. Knowing that the objectives of the KBF are well defined, this study aimed to identify forest plant species of socio-economic importance to the local populations living around the KBF. Also, this study aimed to propose strategies that reconcile the local population's well-being and the preservation of the KBF. Given the high dependence of local communities on the forest, a socio-economic survey was carried out in 51 households. Therefore, 40 species of socio-economic importance were found, and six products and services, namely food, medicinal products, raw materials for handicrafts, edible caterpillar species, timber, and income generating, were identified. For 86% of the local people, the availability of these plant species has decreased significantly compared to 10 years ago; the main causes identified were illegal logging (32%) and agriculture (21%). According to occurrence frequency citation, Baillonella toxisperma Pierre (65%), Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill. (38%), and Ricinodendron heudelotii (Baill.) Heckel (30%) were identified as the flagship socio-economic plant species that local people would like to introduce into their farms to ensure their sustainability. Identifying plant species of socio-economic importance, their availability, and their threats provides substantial information that could help the authorities manage the KBF to plan conservation activities better, considering the local population's well-being.
Classification of forest vegetation in Yaraligöz Education and Observation Forest, Kastamonu, Türkiye
Authors: KARAKÖSE MUSTAFA , TERZIOĞLU SALIH
Published: December 2023

Abstract. Karaköse M, Terzioglu S. 2023. Classification of forest vegetation in Yaraligöz Education and Observation Forest, Kastamonu, Türkiye. Nusantara Bioscience 15: 161-171. Forest ecosystems, which contain approximately half of the 12,975 plant taxa known to be distributed in Türkiye, are very important in terms of biological diversity. The fact that forests are seen as wood-producing ecosystems and have been planned for these purposes for many years has resulted in forests being kept away from being evaluated in terms of ecosystem and socio-economic aspects. Today, forest management plans have begun to be prepared in which all components of the forest are considered, and biological diversity is reflected. Based on this understanding, this investigation was performed during 2011-2012 to analyze the forest vegetation of Yaraligöz Education and Observation Forest. The study area is located in the north-western part of Türkiye within the Euro-Siberian phytogeographic region. Phytosociological studies were carried out using the classical Braun-Blanquet approach, and 51 relevés were collected from the research area. The database contains 184 vascular plant taxa, dominated by the Euro-Siberian elements and Hemicryptophytes. The relevés were classified using the Modified TWINSPAN, and the forest vegetation types' distribution was analyzed using non-metric multi-dimensional scaling. A comprehensive comparison among all described syntaxa within the study area and other closely related forests was provided. Topographic factors and mean Ellenberg indicator values were evaluated to interpret the ecological relationships among forest plant associations. Four associations, two (Daphno pontica-Pinetum hamatae and Galio rotundifolii-Abietum equi-trojani) of which are new syntaxa to science, were defined as belonging to the Euxine Province within Erico-Pinetea, Carpino-Fagetea sylvaticae, Quercetea pubescentis, and Vaccinio-Piceetea. The distribution of these four forest associations was mostly affected by light intensity, nutrients, moisture content, and altitude. The results of this vegetation study provided precious knowledge for monitoring vegetation change and nature conservation projects in the Yaraligöz.
Habitat characteristics, population structure, distribution, and regeneration status of Taxus wallichiana in South Vietnam
Authors: HOP NGUYEN VAN , XIONG CHEN CHANG , QUY NGUYEN VAN , LUONG NGUYEN THI
Published: December 2023

Abstract. Hop NV, Xiong CC, Quy NV, Luong NT. 2023. Habitat characteristics, population structure, distribution, and regeneration status of Taxus wallichiana in South Vietnam. Nusantara Bioscience 15: 179-188. Taxus wallichiana Zucc. is an endangered plant species with high economic value, making it threatened to extinction. Biological information about this species is therefore essential for its conservation. This study is aimed to assess the habitat characteristics, population structure, distribution, and regeneration status of T. wallichiana in South Vietnam. Vegetation surveys were conducted from 2016 to 2021 in three regions in Lam Dong Province. The study revealed that it was distributed in regions with monsoon climate with a total extent of ??379.57 ha, with habitats located on the hillside, narrow shelves, dissected terrain, high slope, on feralite soil with light brown to yellow, red, the soil layer thickness over 0.3 m and in clusters or streaks. The study recorded 634 trees with a diameter at breast height (DBH)?25 cm and 137 trees with 6 cm ?DBH<25 cm. The trees were found primarily at 1401-1500 m above sea level in a mixed broadleaved-coniferous forest. The growth indicators of DBH and overall height (Hvn) developed strongly, but the stand volume was low owing to low tree density. The exponential function was the most suitable for simulating the relationship between Hvn and DBH. Seven thousand six hundred and seventy-three regenerating young individuals were recorded with low density. The density of the regenerating trees decreased as the tree height increased. The finding of this study suggests that T. wallichiana faces the danger of extinction, so solutions are required to conserve and develop this threatened species.
The link of socioeconomic importance to the conservation status of the Mediterranean endemic plants in Egypt
Authors: SHALTOUT KAMAL , BEDAIR HEBA , EL-KHALAFY MOHAMED MAHMOUD , KESHTA AMR , HALMY MARWA W. A.
Published: December 2023

Abstract. Shaltout K, Bedair H, El-Khalafy MM, Keshta A, Halmy MWA. 2023. The link of socioeconomic importance to the conservation status of the Mediterranean endemic plants in Egypt. Nusantara Bioscience 15: 189-211. Mediterranean Basin is the second world's richest hotspot and one of the most critical spots on the planet for endemic species. Therefore, the present study aimed at screening the Mediterranean endemics and evaluating the uses of recorded taxa quantitively through developing new indices and updating the existing ones. Indeed, Semi-structured interviews were used with 43 informants. Relative Cultural Importance (RCI), Species Conservation Importance (SCI), and Relative Medicinal Importance (RMI) indices were applied to determine the most valuable taxa. A preliminary list of 65 Mediterranean endemic species belonging to 49 genera and 22 families in Egypt was compiled from the available literature. Fifty-seven (87.7%) species have at least one aspect of the potential or actual economic value. The most represented use category was the medicinal value (39 taxa: 69.6%). Thymbra capitata (L.) Cav. was mentioned in the highest use categories (NU: 5). Veronica syriaca Roem. & Schult. attained the maximum ethnobotanical Relative Importance (RI) index value. It is crucial to shed light on the cultural value of Mediterranean endemics to guide future management planning to support the conservation and sustainable use of these critical species.
The initial complete chloroplast genome of Ludisia discolor in Vietnam
Authors: Ho Viet The
Published: December 2023

The medicinal plant Ludisia discolor has been highly valued for its effectiveness in treating various diseases. To better understand its genetic makeup, the complete chloroplast genome (cp) of this plant from Vietnam was sequenced, annotated, and compared with published cp genomes. The results of this study revealed that the complete cp genome of L. discolor is 151,876 bp in size consisting of 96 protein coding genes, 12 rRNA and 33 tRNA genes. Total 53 simple sequence repeats were detected in this genome, most of them are polyA and polyT. Genomic comparisons revealed significant differences between the cp genomes of L. discolor from Vietnam with other accessions from China. These findings could provide valuable insights for the taxonomy, plant identification, breeding, and conservation programs of L. discolor in Vietnam.
Screening for endophytic bacteria from Ambon Banana (Musa paradisiaca) as biocontrol agent of anthracnose (Colletotrichum gloeosporioides) on bananas fruit
Authors: PANGASTUTI ARTINI , PRATIWI HESTI , SETYANINGSIH RATNA
Published: December 2023

Abstract. Pangastuti A, Pratiwi H, Setyaningsih R. 2023. Screening for endophytic bacteria from Ambon Banana (Musa paradisiaca L.) as biocontrol agent of anthracnose (Colletotrichum gloeosporioides) on bananas fruit. Nusantara Bioscience 15: 238-244. Post-harvest Ambon Bananas (Musa paradisiaca L.) are sensitive to anthracnose disease, caused by Colletotrichum gloeosporioides, and causes the fruit to rot quickly. Thus, chemical fungicides are employed, damaging living organisms and the environment. One solution is biocontrol using endophytic microorganisms as antagonistic agents against the anthracnose fungus that causes anthracnose disease. This study aimed to obtain potential endophytic bacteria from the Ambon Banana plant that had inhibitory activity against the growth of the pathogenic fungus C. gloeosporioides that causes anthracnose in bananas. Endophytic bacteria were recovered from Ambon Banana roots by crushing plant components. Therefore, bacterial isolates were tested for antagonistic interactions with pathogenic fungi using the dual culture approach. The 16S rRNA gene sequence analysis was used to identify bacterial isolates with the most significant inhibitory potential. According to the findings of this study, seven isolates of endophytic bacteria, A2-1, A2-2, A5-2, A6-2, A6-3, A8-1, and A9-1, can limit the growth of the pathogenic fungus C. gloeosporioides. The strain A6-3, identified as Pseudomonas pseudoalcaligenes, exhibited the greatest potential as a biocontrol agent against the pathogenic fungus C. gloeosporioides. It achieved the highest inhibition rate of 43.59%, resulting in an extended fruit shelf life and reduced harm susceptibility.
Effect of phosphate solubilizing and nitrogen-fixing bacteria on Pontianak siam citrus (Citrus ×nobilis var. microcarpa) seed germination
Authors: ADHYANINGTYAS RETNO FIKRIA IDIL , RAHMAWATI RAHMAWATI , MUKARLINA MUKARLINA
Published: December 2023

Abstract. Adhyaningtyas RFI, Rahmawati, Mukarlina. 2023. Effect of phosphate solubilizing and nitrogen-fixing bacteria on Pontianak siam citrus (Citrus ×nobilis var. microcarpa) seed germination. Nusantara Bioscience 15: 245-250. West Kalimantan is one of Indonesia's largest producing areas for Siam citrus (Citrus ×nobilis var. microcarpa Hassk.). It is necessary to carry out the proper treatments within the early stages of planting, which increases the speed of germination of citrus seeds to quickly increase the number of seedlings. The biological agents that play a role in promoting plant growth are a group of Plant Growth-Promoting Rhizobacteria (PGPR), consisting of Phosphate-Solubilizing Bacteria (PSB) and Nitrogen-Fixing Bacteria (NFB). This study aims to determine the effect of a combination treatment or a single treatment of phosphate-solubilizing and nitrogen-fixing bacteria, which is known to obtain the best results in the germination and growth of Siam citrus seeds. The study was conducted in a nonfactorial, Completely Randomized Design (CRD). The given treatments were control (without bacterial inoculum), nitrogen-fixing bacteria (NFB P1), phosphate solubilizing bacteria (PSB P2), a combination of NFB and PSB bacteria with a ratio of 1:1 (P3), a combination of NFB and PSB bacteria with a ratio of 2:1 (P4), and the combination of NFB and PSB bacteria with a ratio of 1:2 (P5). Observations were made for 4 weeks after planting. A single treatment with phosphate-solubilizing bacteria (P2) gave the best result on almost all parameters, such as germination percentage, emergence time of germination, root length, number of leaves and fresh weight of Siam citrus seedlings.
The potency of Berastagi sweet orange (Citrus sinensis) peel extract for obesity treatment: An experimental study in male rats
Authors: BATUBARA WINDA RIZKI PEBRINA , SUSILAWATI TRI NUGRAHA , INDARTO DONO
Published: December 2023

Abstract. Batubara WRP, Susilawati TN, Indarto D. 2023. The potency of Berastagi sweet orange (Citrus sinensis) peel extract for obesity treatment: A study in the rats. Nusantara Bioscience 15: 251-257. Obesity is an abnormal accumulation of body fat and is a trigger factor for various degenerative diseases. Obese continues to grow every year in the world. This study aimed to investigate the effects of Orange Peel Extract (OPE) on Body Weight (BW), obesity index (Lee Index), Body Fat Percentage (BFP) and visceral fat in obese-model rats. Thirty male Wistar rats were divided into 5 groups: controls (negative/NC given aquadest and positive/PC given orlistat 12.3 mg/kgBW/day) and interventions (OPE 1-3) given OPE 250, 500 and 750 mg/kgBW/day, respectively. All rats were fed a high-fat, high-fructose (HFHFr) diet for 28 days. Statistical analysis was performed using ANOVA and Friedman test with p<0.05. The average BW in all groups increased significantly after 14 and 28 days of the intervention (p=0.005). A significant decrease in the obesity index average was found in the OPE 2 and 3 groups (p=0.028 and p=0.034) compared to the NC group. The OPE 1-3 and PC group significantly decreased in average BFP compared with the NC group on the 28th day of intervention (p<0.05). In conclusion, OPE can reduce obesity induced by HFHFr. Future research could be directed to evaluate the OPE side effects for obesity treatment.
Optimization of L-asparaginase production from endophytic bacteria isolated from the mangrove Rhizophora mucronata
Authors: NAFISATURRAHMAH ARIN , SUSILOWATI ARI , PANGASTUTI ARTINI
Published: December 2023

Abstract. Nafisaturrahmah A, Susilowati A, Pangastuti A. 2023. Optimization of L-asparaginase production from endophytic bacteria isolated from the mangrove Rhizophora mucronata. Nusantara Bioscience 15: 279-287. L-asparaginase is an enzyme that hydrolyes L-asparaginase to L-aspartate and ammonia. L-asparaginase has the potential to treat acute lymphoblastic leukemia and other malignant cancers. So far, purified L-asparaginase from Escherichia coli and Erwinea chrysanthemi has been available and applied clinically in humans. However, this treatment has side effects such as allergy, cross-interaction, immune system stimulation, drug resistance, and nonspecific L-glutaminase activity. These side effects can be overcome by discovering new sources of L-asparaginase, which are serologically different but have similar therapeutic effects. This study aims to determine the optimal conditions of endophytic bacterial culture in producing L-asparaginase. Endophytic bacteria were screened using an M9 medium with asparagine as a substrate; the L-asparaginase-producing isolates showed pink zones around the colonies. Optimization of L-aparaginase production by endophytic bacteria is carried out by One Factor at A Time (OFAT). Optimization of enzyme production includes incubation time, temperature, pH, ammonium sulfate levels, and glucose concentration in the bacterial growth medium; determination of enzyme production by Nesslerization method. The results showed that 8 isolates could produce high L-asparaginase, 14 isolates had medium ability, 30 isolates had low ability, and 2 bacterial isolates did not produce L-asparaginase. Endophytic isolates were able to produce the highest L-Aparaginase under different optimal conditions. The optimal incubation time for endophytic isolates in this study was 60-84 hours, the optimal temperature was 37ºC, the optimal pH was 7, the nitrogen content was 0.25 mg/L, and the optimal glucose level was 3%.
Potential effects of fermented moringa (Moringa oleifera) leaf extract to increase the color brightness of the Oranda goldfish (Carassius auratus)
Authors: UMAIYAH SITI , PUTRA ACHMAD NOERKHAERIN , HERJAYANTO MUH. , SYAMSUNARNO MAS BAYU
Published: December 2023

Abstract. Umaiyah S, Putra AN, Herjayanto M, Syamsunarno MB. 2023. Potential effects of fermented moringa (Moringa oleifera) leaf extract to increase the color brightness of the Oranda goldfish (Carassius auratus). Nusantara Bioscience 15: 288-296. Moringa (Moringa oleifera Lam.) leaf extract serves as a natural reservoir of carotenoids, prominently ?-carotene, effectively employed to augment the color quality of ornamental fish. This study aimed to evaluate the potential effects of adding fermented moringa leaf extract to feed to enhance the color vibrancy of Oranda goldfish (Carassius auratus (Linnaeus, 1758)). Moringa leaves were also fermented using Aspergillus niger Tiegh. at a dosage of 0.5 g/100 g for 48 hours, followed by extraction using 70% ethanol. Four doses of fermented moringa leaf extract (0, 40, 50, 60 mL/kg) with three replications were added to a commercial feed using the coating method. The results showed that the carotene in fermented moringa leaf extract is 94.22 ppm/50 mL. Adding moringa leaf extract to the feed enhanced the Oranda goldfish's brightness and color diversity. The addition of fermented moringa leaf extract at a dose of 60 mL/kg led to the highest color diversity values on the body (57.81%), caudal (71.71%), and head (71.13%) compared to other treatments. Moringa leaf extract did not affect growth rate, survival, blood profile, and water quality parameters for maintaining Oranda goldfish. The extract from A. niger had the potential to be used in the cultivation of Oranda goldfish, and the addition of 60 mL/kg achieved the best color brightness and diversity.
ADAPTIVE POTENTIAL OF SPRING WHEAT ACCESSIONS FOR THE CONTENT OF ANTIOXIDANTS IN GRAIN IN THE CONDITIONS OF EASTERN SIBERIA
Authors: Polonsky Vadim Igorevich , Sumina Alena Vladimirovna
Published: December 2023

The aim of the study is to determine the adaptive potential of wheat accessions grown in Eastern Siberia in terms of the total content of antioxidants (TAC) in the grain and 1000 grain weight, as well as to analyze the relationship between the adaptability indicators of accessions for these traits. The object of the study were 7 accessions of spring wheat, which were grown in three ecological points: Krasnoturansky GSU (Krasnoyarsk Territory), Beisky GSU (Republic of Khakassia) and Piy-Khemsky GSU (Republic of Tyva). The HTC values for these items were respectively: 1.50, 1.25, 0.93. For wheat accessions, 1000 grain weight and the TAC value were determined. Grain extraction was carried out using hot bidistilled water, the TAC level was measured on a Tsvet Yauza-01-AA device, gallic acid was used as a reference sample. For each of these traits, 5 adaptability parameters of wheat accessions were calculated: coefficient of ecological variation Cv, stress resistance index d, homeostatic parameter Hom, index of level and stability of the variety PUSS, stability factor SF. It is shown that the conditions for growing wheat (point) did not significantly affect the value of TAC in the grain. It was found that the variability of this trait is mainly due to the wheat genotype. It has been established that the optimal values of adaptability parameters and the smallest sum of ranks both in terms of TAC in the grain and in 1000 grain weight were characteristic of the same Omskaya Krassa wheat accession. A positive relationship was found between each indicator of adaptability in terms of the level of TAC in the grain and that in terms of 1000 grain weight, while the correlation was significant for the stability indicators Hom and PUSS. The recorded results suggest a high probability of obtaining wheat accessions with increased stability in terms of TAC in grain when selecting forms for high stability in terms of grain size and vice versa. The discovered effect is the basis of a new method for screening wheat genotypes for an increased level of adaptability in terms of the content of functional substances in the grain – antioxidants, using data on 1000 grain weight instead of the laborious method of their direct measurement for the corresponding calculations.
ANOTHER FIND OF THE EASTERN MIRROR WITH SPHINXES ON THE MIDDLE YENISEI
Authors:   Institute of Archaeology and Ethnography SB RAS, A. Borodovskiy
Published: December 2023

The article is devoted to the publication of another metal button mirror with paired figures of sphinxes and a floral ornament with a Kufic inscription, recently discovered on the territory of the Middle Yenisei. In this region, similar items are not only rare (exhibits of the Minusinsk and Abakan museums), but are also markers of the northern border of the distribution of these items in the Mongolian time. The сlarity of the decoration details of the product gives every reason to consider it far from being the latest copy from the original. Sufficiently good preservation of the images on the mirror (epigraphics, fantastic animals and floral decorations) makes it possible to analyze in detail not only individual artistic details, but also to make a probable attribution of the origin and chronology of this object. The peculiarities of the style of the Kufic inscription and images of sphinxes make it possible to date the mirror no later than the 11th–12th centuries, and also to include it in the circle of objects produced in Iran or Central Asia. The absence of such imported items in the south of Western Siberia north of the middle reaches of the Yenisei River is probably due to the historical features of the cultural ties of the medieval population in the initial period of the 2nd millennium AD. Overall, the new find of a mirror with a Kufic inscription and a paired image of the sphinxes on the background of a floral ornament makes it possible to clarify the local and general features of the distribution of such items in Eurasia in the Middle Ages. This, in turn, provides certain grounds for reconstructing the dynamics of the changes in the external relations of Southern Siberia over the past millennium.
ON THE ISSUE OF IRMEN JUGS
Authors:   T.F. Gorbachev Kuzbass State Technical University, S. Kovalevsky ,   Russian State Institute of Performing Arts, Siberian Higher School of Music and Theatrical Art
Published: December 2023

The article is devoted to such a category of ceramic inventory of the Irmen cultural and historical community of the south of Western Siberia as jugs. It was revealed that this type of tableware was made by the Irmen population quite rarely. A comparative analysis of the distribution of jugs in various territories showed their more frequent use by the population of the northeastern part of the Irmen world, formed on the basis of the previously existing Elovo culture here. Special attention in the conducted research is paid to the context of finding jugs within settlements and burial mounds. It was shown that vessels of this type in some cases were not broken and discarded dishes. The y were often placed several copies together and in specially designated places, obviously playing a certain role in ritual practice. The peculiarity of vessels of this type was also manifested in the specifi c ornamentation, indicating their special purpose.
WEAPONS ITEMS FROM THE SHELOMOK-I BURIAL MOUND
Authors:   Altai State University, I. Ragimkhanova
Published: December 2023

The purpose of the publication is to introduce into scientific circulation a collection of weapons of the Shelomok culture found at the Shelomok-I burial mound. As a result of the archaeological study of the burial ground in 2018, 2019 and 2021, 11 burials were investigated, 3 of which may be classified as military ones. Armament items are represented by bronze and bone arrowheads, a butt, a quiver hook, a bronze model of a bow, armor plate and a mace. According to the totality of the artifacts found, the burial mound of Shelomok-I, are dated to the 4th — 2nd centuries BC. To date, the volume of available weapons of the early Iron Age found in the Tomsk Region remains very limited, so the introduction of materials from the Shelomok-I burial mound into scientific circulation is of particular importance.
TECHNICAL AND TECHNOLOGICAL ANALYSIS OF THE ANDRONOVO CULTURE CERAMICS FROM THE FIRSOVO-15 SETTLEMENT (EXCAVATION MATERIALS 2020)
Authors:   Altai State University, A. Fedoruk , I. Valkov ,   Federal Research Center of Coal and Coal Chemistry SB RAS
Published: December 2023

The paper presents the results of the technical and technological analysis of Andronovo ceramics obtained during the rescue excavations in 2020 at the multi-time settlement of Firsovo-15. The composition of the raw materials and molding masses of 18 samples was studied. It was found that most of the vessels were made of medium-hard plastic clays. In total, two recipes for composing molding masses have been identifi ed: clay + chamotte + organic solution, clay + chamotte + organics. Comparison of the data obtained with the result of earlier studies of the materials of the monument allows us to speak of a high degree of uniformity of the Andronovo ceramic complex of the Firsovo-15 settlement. A comparative analysis of the results with the available information on the technology of making ceramics of other Andronovo settlements of Altai demonstrates some originality of the studied complex. It consists in a small variety of recorded recipes, as well as in the presence of the only one type of mineral impurity in the studied sample. The results obtained indicate that the population who left this site had stable traditions in the selection of raw materials and the composition of molding masses, as well as its cultural unity.
NEW DATA ON THE AGE OF ANCIENT IRRIGATED AGRICULTURE IN TUVA
Authors:   Biosphere Research Center of the Republic of Tyva, T. Prudnikova
Published: December 2023

According to the conducted research, the Republic of Tuva is an area of ancient agriculture, which was facilitated by the geographical location and natural conditions, first of all, the mountainous terrain and the abundance of rivers in this territory. Practically in all river valleys of the region there are various irrigation systems corresponding to the capabilities of technology and the organization of social labor of certain historical periods. Here you can observe all the stages of irrigation development. According to В.А. Latynin’s classification, it is the stage of early irrigated agriculture, the stage of the simplest types of irrigation channels that turn into complex fan irrigation systems. The presence of the rudiments of agriculture in the Neolithic is evidenced by the finds of pollen of cultivated barley aged 6–5 thousand years in the valley of the Small Yenisei, made by S.B. Potakhin. Mining and ore production contributed to the development of agriculture in the Bronze Age — there are large copper deposits in the bowels of Tuva. According to the conducted research, developed irrigated agriculture existed in this territory in the Xiongnu period (Ubsunur basin, SOAN-9199; East Tuva Highlands, SOAN-9201). In 2022, radiocarbon dating was obtained for the first time, confirming the presence of irrigated agriculture in Tuva in the 1st millennium BC, Scythian-Saka time.
ARCHAEOLOGICAL RESEARCH OF A.N. MOLOTILOV IN THE BARABINSK FOREST-STEPPE IN 1912
Authors:   The Museum of Local History of Novosibirsk, A. AVTUSHKOVA
Published: December 2023

The article presents the activities of A.N. Molotilov, a student of the Imperial Tomsk University, a member of the Tomsk Society for the Study of Siberia and the Improvement of its Way of Life in the field of the study of archaeological sites in the Barabinsk forest-steppe in 1912. In the northern part of Baraba and on the coast and islands of Lake Chany, he investigated archaeological sites, including the now famous Voznesenskoye, Chinyaikha, Tyumen settlements, etc. A.N. Molotilov professionally describes the studied objects and is considered one of the first to think about the protection of archaeological heritage. The location of many of the sites discovered by A.N. Molotilov is still unknown. However, the results of his work remain relevant to this day. The article also suggests the possible location some of archeological sites discovered of A.N. Molotilov.
CERAMIC DISHES OF THE PAZYRYK CULTURE FROM THE SITES DISCOVERED IN ALTAI IN THE PRE-REVOLUTIONARY PERIOD AND IN THE 1920s
Authors:   Altai State University, A. Tishkin , J. Mu ,   Altai State University
Published: December 2023

The ceramic dishes belong to the category of mass archaeological sources in the study of the Pazyryk culture of the Scythian-Saka time. However, the degree of study of such products leaves much to be desired, although their information potential is beyond doubt. In this case, not only quantitative indicators and qualitative characteristics are important, but also the implementation of the program of interdisciplinary analysis, as well as the history of detection. The article examines the process of accumulating information about the fi nds of the clay vessels at the initial stage of excavation of the sites of the Pazyryk culture. From 1865 to 1929, expeditions led by V. V. Radlov, N.M. Yadrintsev, S.I. Rudenko and other researchers explored the Altai Region. In the course of this work, a lot of information was obtained, which is still in demand today. The results of the first analytical conclusions and their interpretation are noted. Color illustrations of some jugs are given. It is noted that some finds could not be found in the museum collections. There are problems with the level of publication materials, which requires additional archival research.
EVERYTHING CHANGES, NOTHING DISAPPEARS — TO THE ANNIVERSARY OF MIKHAIL VASILIEVICH SHUNKOV
Authors:   Institute of Archaeology and Ethnography SB RAS, M. Kozlikin , A. KUNGUROV ,   Altai State Museum of Local Lore, D. Papin ,   Altai State University,   Institute of Archaeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, A. Tishkin ,   Altai State University
Published: December 2023

The biographical essay is dedicated to the 70th anniversary of the famous researcher of the Eurasia ancient past — Mikhail Vasilyevich Shunkov, whose scientific activity relates to the solution of such fundamental problems as human settlement in the North and Central Asia territory,the formation and development of cultural traditions at diff erent stages of the Paleolithic, geochronology, Pleistocene paleogeography and paleoecology of ancient human. Signifi cant dates and events in the life of the hero of the day that infl uenced his formation as a scientist are given. It tells about the active scientifi c-organizational and expeditionary activities of the researcher. The essay also presents the most important scientifi c results of Mikhail V. Shunkov, obtained mainly during a comprehensive study of the multilayer Paleolithic objects of Altai, such as the Denisova Cave and the Karama Early Paleolithic site. Publication activity, pedagogical activity and the main directions of the administrative work of the scientist are covered.
Feasibility Study of Digital Administration and Digital Marketing of SMEs Products at The Investment Gallery of Manado State Polytechnic
Authors: Paendong Melky , Kumaat Arief Perdana , Kolondam Arifmanuel , Maramis Diana
Published: December 2023

The challenges for SMEs in Indonesia are growing, especially in terms of competing in an increasingly competitive and dynamic market. One of the efforts that SMEs can undertake to enhance their competitiveness is by leveraging digital technology in managing their businesses, from administrative systems to digital marketing activities for SME products. Therefore, this research aims to conduct a feasibility study of digital administration and digital marketing systems for SME products, with the research location being the Investment Gallery of the State Polytechnic of Manado, which serves as a showcase and sales platform for local SMEs' flagship products, managed by the Marketing Laboratory of the Manado State Polytechnic (Polimdo).This research was conducted using a survey method involving respondents from SMEs participating in the Manado State Polytechnic (Polimdo) Investment Gallery. The collected data were analyzed using both quantitative and qualitative descriptive analysis. The observational results indicate that the majority of SMEs participating have knowledge of digital technology, but only a small portion have implemented it in their businesses.In this context, the use of digital administration and digital marketing systems can help SMEs optimize their administrative processes and enhance efficiency in managing their businesses. Additionally, the use of digital technology can assist SMEs in expanding their markets and increasing their sales. However, despite the significant benefits of using digital technology in SMEs, there are still some challenges to overcome, such as the limited technological knowledge of SME owners. Therefore, the implementation of digital administration and digital marketing systems for SMEs requires a suitable approach to ensure optimal benefits.
Analysis of Incoterms and Relational Resources to Improve Competitive Advantage: A Study of Freight Forwarders Company in Indonesia
Authors: Sugiono Ahmad , Rahayu Agus , Wibowo Lili Adi , Hurriyati Ratih
Published: December 2023

This study aims to analyze the impact of Incoterm and relational resources on the competitive advantage of Indonesian Freight forwarders. The measurement methodology uses structural equation model (SEM) analysis with SmartPLS software to analyze the impact of Incoterms and relational resources on competitive advantage. Through social media, online questionnaires were sent to gather research data. The Likert scale of 5 was used to create the questionnaire. Companies that provide freight forwarding services were the respondents in this study, chosen by simple random sampling. Online questionnaires were distributed to 75 companies to answer questions submitted. The data analysis step is validity tests, reliability tests, significance tests, and hypothesis tests. Based on the data processing results, it is found that Incoterm and relational resources positively affect competitive advantages. The novelty of this study is a model of the relationship between the effect of Incoterm and relational resources on the competitive advantage of freight forwarding companies. The research's theoretical implication is that Freight forwarder companies' management should select appropriate incoterms and implement relational resource policies to encourage increased competitive advantage. One of the limitations of this study is that the sample size used is only a small number of companies engaged in international Freight Forwarder services, only 75 companies.
Enhancing English Language Proficiency in HRM: A Strategic Imperative for Logistics Efficiency
Authors: Rahmawati Yusi , Mege Stacia Reviany
Published: December 2023

Good human resource management is critical to organizational success in the frantic logistics environment. The importance of English language skills in this setting cannot be overstated. This study piece dives into the interconnected connection between human resource management and English language abilities in the logistics sector. The internationalization of trade and the spread of supply chains across borders has prompted the development of a common language for communication. English, as the international corporate lingua franca, is critical in overcoming linguistic gaps across varied logistics teams and stakeholders. This article discusses the significant impact that English proficiency has on numerous facets of logistics operations. This study looks into the critical importance of English language competency in human resource management in the logistics industry, focusing on cross-cultural communication, talent acquisition, and retention. A comprehensive analysis of the literature, case studies, and surveys within the logistics industry was conducted to assess the significance of English language skills. Our research demonstrates a significant link between English language competency and effective cross-cultural communication, which is essential for timely information exchange in logistics operations. The strategic importance of English language ability for logistics organizations is highlighted by this research. In order to enable the staff to communicate effectively and promote operational excellence, it highlights the need for ongoing investment in language training programs. The findings of this study highlight the fact that comprehending English is a strategic need in the field of global logistics, not just a desired talent.