FACTORS ASSOCIATED WITH CONTINUATION OF PALIPERIDONE PALMITATE 1-MONTH FORMULATION MONOTHERAPY IN PATIENTS WITH SCHIZOPHRENIA
Authors: Marumoto *Tatsuro , Horio Hiroshi , Kinoshita Hiroaki , Morita Natsuko , Touma Tokiko , Takebe Kyoko , Wakamatsu Akihide 
Published: February 2025

Background

Schizophrenia often requires long-term treatment with antipsychotics. Paliperidone palmitate long-acting injection (PPLAI) is one of the advantageous options to maintain adherence, prevent relapse and hospitalization (Kishimoto et al., 2021; Tiihonen et al., 2017). In Japan, paliperidone palmitate 1-monthly (PP1M) and paliperidone palmitate 3-monthly (PP3M) have been approved, and the approved patient population for PP3M in Japan is limited to patients with schizophrenia who have been stabilized with PP1M monotherapy. Antipsychotic polypharmacy consisting of LAI and oral antipsychotics (OAPs) are widely used in the clinical practice in many countries (Doshi et al., 2015; Aggarwal et al., 2012; Dimitropoulos et al., 2017; Cordiner et al., 2016; Joo et al., 2019), including Japan (Onitsuka et al., 2023). Hence, LAI monotherapy may be a more appropriate option in the long term. However, to date, factors associated with continuation for LAI monotherapy have not been examined. Therefore, we conducted a post-hoc analysis of a post-marketing surveillance (PMS) to explore factors associated with subsequent treatment continuation in patients who introduced PP1M monotherapy.

Aims & Objectives

The purpose of the post-hoc analysis is to identify factors associated with subsequent treatment continuation in schizophrenia patients in whom PP1M was introduced as a monotherapy.

Method

This study is a post-hoc analysis of the PMS in PP1M in Japan. The case enrollment period was from January 2014 to July 2015, and patients with schizophrenia who received PP1M according to the dosage and administration in the package insert were enrolled. The primary analysis population will be 698 of the 1306 patients enrolled in the PMS who were being treated with PP1M monotherapy treatment at the start of PP1M. Main endpoint will include time to drop out of monotherapy (all causes of dropping PP1M monotherapy). Factors associated with continuation of PP1M monotherapy will be assessed by using cox regression model. In this presentation, we will report on factors associated with subsequent treatment continuation in schizophrenia patients where PP1M was introduced as monotherapy.

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