bluuebunny/crossref_metadata_2025 huggingface dataset:
Z KUŞAĞININ KÜLTÜREL MİRAS ALGISI: SAFRANBOLU ÖRNEĞİ
Authors: KOCAKAYA Elif , DÖNMEZ Yasin
Published: August 2022

Dünya tarihi incelendiğinde kuşaklar arası farklılıkların yaşadığı zaman ve coğrafyaya göre değişiklikler içerdiği bilinmektedir. Savaş gören kuşaklar ile teknoloji gören kuşaklar arasında belirgin farklılıkların olduğu görülmektedir. Kuşaklar incelendiğinde bulundukları dönemin kriterlerine göre farklı ifadelerle anılmaktadır. Dünyanın teknolojik nesli olarak kabul edilen ve 2000 sonrası gençleri oluşturan z kuşağı son dönmelerin en popüler kuşak türüdür. Her şeyin hızla tüketildiği küreselleşen dünyada tarih bilinci oluşmuş, kültürel köklerini iyi tanıyan kuşaklar uluslar açısından büyük önem arz etmektedir. Geçmişin bir yansıması olan kültürel miras değerlerini geleceğe en iyi taşıyan ve insanlığın devamına katkı sağlayacak olan günümüzün gençlerini oluşturan Z kuşağıdır. Bu bakımdan tarihi bir dokuya sahip olan Safranbolu kentinde Z kuşağı ölçüt alınan çalışma amaçlanmıştır.

Gerçekleştirilen bu çalışmada bir dünya miras kenti olan Safranbolu’da Z kuşağının kültürel miras algısı ve bakış açısı araştırılarak literatüre somut katkıda bulunmak hedeflenmiştir. Çalışmadan elde edilen bulgular neticesinde gençlerin kültürel mirası ilk olarak okul döneminde duydukları gözlemlenmiştir. Kültürel miras değerlerinden görsel ve işitsel medyada sıkça yer alan popüler kültür öğeleri ilgilerini çektikleri belirlenmiştir.

Yürütülen bu araştırma sonucunda elde edilen bulgularla hem kültürel mirasın gelecek kuşaklara aktarılması hem de araştırmacıların araştırma süreçlerine katkı sağlaması amaçlanmıştır. Çalışmada günümüz gençlerinin kültürel miras bilincini artıracak önerilere yer verilmiştir.
PENGABDIAN KEPADA MASYARAKAT USAHA PANGAN LOKAL BERBASIS TEPUNG UBI DI TEMPILANG KABUPATEN BANGKA BARAT
Authors: Kurniawan Zaldy , Subhan Muhammad
Published: August 2022

The development of various processed cassava with good quality will support local government programs in realizing food security through the development food diversification of local, namely cassava. This Community Partnership Program (PKM) activity is the Ubi Flour Processing Business Group in Tempilang Village. The sweet potato flour produced is made of processed products such as aruk rice, sweet potato noodles, and cakes. From the survey and analysis together with partners, the problems faced by partners, namely regarding production problems related to increasing production capacity and aspects of business management. So far, the process of the production stage is done manually which requires a lot of manpower and time so that it is less productive. From these conditions, the solution taken is first to procure a cassava flour squeezer which has a function to squeeze the sweet potato flour with the help of a threaded shaft drive system and a hydraulic pump with a tool capable of 5 Kg at a time, second is to carry out training on machine operation and maintenance so partners understand about the use and maintenance of tools properly and correctly, and third is to evaluate and monitor partners to measure the success rate of production problems, whether there has been an increase or not. During monitoring, before the press, the production process takes 30 minutes to produce 5 kg of sweet potato flour. However, with the squeezer it takes only 5 minutes to produce 5 kg of sweet potato flour.
IPTEK BAGI MASYARAKAT MESIN PENCACAH PELEPAH DAN DAUN KELAPA SAWIT UNTUK PAKAN SAPI DI DESA SEMPAN
Authors: Pristiansyah Pristiansyah , Hasdiansah Hasdiansah , Sugiyarto Sugiyarto
Published: August 2022

The growth and development of cattle is very dependent on the maintenance process, including the availability of feed in the surrounding environment, to meet the daily needs of cattle. In order for cow feed to be available and available, it is necessary to have a natural source of cow feed because it is easily available and has a high level of availability, namely in the natural surroundings. This natural source is in the form of grass or leaves that can be consumed directly by cattle, the availability of the feed is not influenced by weather conditions so that it can be obtained anytime and in large quantities. The grass that is available in the environment can be eaten directly by the cows, but the leaves must be processed first to make it easier for the cows to eat. For example, oil palm leaves and fronds, because the size of the palm fronds is quite large, so they cannot be directly used, it is necessary to have a chopping process so that they can be consumed by cows. Of course, the census process manually can be done but it is not effective, it requires a lot of time and a lot of effort. Based on these problems, it is necessary to mechanize the chopping process in order to simplify the process. The purpose of science and technology for the community in cattle breeder farmer groups in general is to increase the quality and capacity of production, especially cattle. Meanwhile, in particular, this IbM activity is expected to collaborate between partners and proposers from educational institutions. Partners can develop their business because they can meet the need for more animal feed through appropriate technology machines in the form of animal feed chopper machines, while institutions can apply science and technology directly and apply their knowledge into appropriate technology and can also introduce Polman educational institutions to the wider community.
PkM MESIN PEMOTONG TEMPE BAGI KELOMPOK USAHA PENGRAJIN KERIPIK TEMPE PELANGI
Authors: Yudo Eko , Ariyanto Ariyanto
Published: August 2022

Tempe is a typical Indonesian food with various preparations. One of the products is tempe chips, which are also home-made. The purpose of applying technology for home processing for partners is to improve the quality and production capacity of tempe chips. The results of the survey on partners making tempeh chips, it was found that the problems that occurred in partners were that the process of cutting tempeh was still manual by using a kitchen knife to cut or slice tempeh. So it takes a long time and the results of the slices or pieces of tempeh produce thin and thick dissimilarities of tempeh pieces. The solution given is the technology of cutting or slicing tempeh to make it easier to cut tempeh with the same results from thickness and thinness. The cutting results obtained are an average of 2.58 seconds/cut with a thickness of 1 mm having a texture that is not broken/cracked. In the process of producing tempeh chips, the partner's business increased by 69%.
PKM USAHA PANGAN LOKAL PEMBUATAN KERIPIK TEMPE
Authors: Zaldy Zaldy Kurniawan , Rollastin Boy
Published: August 2022

Snacks are the lifeblood of the Home Industry Community (IKM), which is still developing. One of the potential producers of local food as a typical Bangka snack is in the northern part of Bangka Island, Belinyu District, Bangka Regency. Bukit Ketok Village in Belinyu District is a granary that produces snacks. One of the home industries that produces various snacks in the form of chips made from tempeh is being developed. This tempe chip product is produced by manual slicing of tempeh using a knife, so the results are less productive and not optimal because it requires a lot of energy and time. In addition, education and innovation are needed to increase their production capacity. Therefore, we need an appropriate technology machine capable of slicing tempe with the desired thickness and uniform size with a semi-automatic slicing system with a processing capability of 10kg/hour. The method used is the procurement of a tempe slicing machine, training on machine operation and machine maintenance. Thus, the training can be easily understood by partners properly and correctly. After that, evaluation and monitoring are carried out to partners so that the level of success of the production process can be measured. The output targets resulting from this community service are media publications, production machines and increased partner production.
A Case Study on the Digital Transformation Festivals due to the Covid-19 Pandemic
Authors:   The Korean Society of Culture and Convergence, Lee Seonmi
Published: August 2022

This study is intended to comparatively study domestic and foreign festival cases that successfully continued festivals through digital transformation during the COVID-19 pandemic, and to draw implications. Selected examples are the 2nd of May Festival in Madrid, Spain, the DESECE Children’s Festival in Greece, and the online Gangneung Danoje Festival. As a result of the analysis, the Digital Transformation Festival is first, the most prioritized point in the digital transformation of the festival is the theme of the festival, so it is not the use of digital technology itself. Second, the digital transformation festival established a hybrid festival model in which live and digital coexist. Third, social media became the basis for the success of the digital festival. Fourth, it provided an opportunity to build an archive of existing festivals. Fifth, the COVID-19 crisis improved festival services by introducing a visiting festival program.
A Study on the Effect of Learning Community Activities on the Core Competencies of College Students
Authors:   The Korean Society of Culture and Convergence, Kwon Miae , Kim Mikyung
Published: August 2022

The purpose of this study is to reveal the relationship between learning community activities and core competencies. A pre-post-test of core competencies was conducted on participants in the K University's learning community program, and interviews with participants were conducted to find out the specific significance of the experience of participating in the learning community and core competencies. The results of the study are as follows. First, it was confirmed that all six core competencies of K University improved overall with the participation of the learning community. Second, the degree of improvement in core competency was different according to the nature of the learning community program. Third, it was found that the participation experience of the learning community not only forms individual learning habits but also creates various learning synergies.
Analysis of the Relationship between Learning Attitude, Self-directed Learning Ability, Learning Flow, Problem Solving Ability of Learning Community Participants: Focusing on the Extracurricular
Authors:   The Korean Society of Culture and Convergence, Kwon Youngae , Park Hyejin
Published: August 2022

This study explored the relationship between learning attitude, self-directed learning ability, learning flow, and problem-solving ability of students who participated in the learning community program. For this purpose, a survey was conducted with students who participated in the learning community. The study results are as follows. First, learning attitude and self-directed learning ability were found to have a significant effect on learning flow. Second, learning attitude and self-directed learning ability were found to have a significant effect on problem solving. Third, as a result of analyzing the mediating effect of learning flow in the effect of learning attitude and self-directed learning ability on problem-solving ability, it was found to have a partial mediating effect. It can be seen that in collaborative learning situations, students maintain a positive learning attitude to achieve their learning goals and have a positive effect on learning outcomes through learning flow experiences.
A Comparative Study on the Educational Effect between the Class Using Havruta and Debate Class: Focusing on Core Competencies of 3C
Authors:   The Korean Society of Culture and Convergence, Shin Jungsuk
Published: August 2022

This study conducted the debate class and class using Havruta targeting the students who were taking a general education course called  in C university. In the results of comparing the improvement of self-directed competency, creative/convergent competency, and considerate/collaborative competency, the class using Havruta showed the higher educational effects than debate class.
Such results of this study must be originated from the fact in which Havruta could induce students’ active participation in class more than debate; Havruta could improve the bond and consciousness of collaboration between students; and the Havruta teaching method develops ‘thinking power’. However, the class using Havruta caused pressure and resistance because of its unfamiliar teaching method in which the whole process should be designed and proceeded by students. In order to solve this, it would be necessary to develop various teaching models and effective learning materials for classes using Havruta.
A Study on the Drama by Park Jaebum: Focusing on Anti-hero Trilogy ,  and
Authors:   The Korean Society of Culture and Convergence, Lee Daun
Published: August 2022

Park Jaebum made his debut as a drama writer through  in 2003 and established a distinctive world of works starting from  (KBS2, 2017). , , and . In conclusion, the anti-hero trilogy by Park Jaebum based on the primitive vengeance of the anti-hero and showed the characteristics of varied heroic narrative, and displayed similarity where the anti-hero and ordinary citizens are in unity and block out cartel, the antagonist. Moreover, the anti-hero trilogy by Park Jaebum contains the nature of crimes inference investigation, but it stands out from regular genre drama as comedy is actively applied. Especially, Park Jaebum’s anti-hero trilogy actualizes laughter through verbal humor, situational humor, and satire and parody and this shows similarity with entertainment effects and the relief of dramatic tension.
A Study on Gyobang Dance and Music in Honam Area of the Joseon Dynasty
Authors:   The Korean Society of Culture and Convergence, Yanng Jiseon
Published: August 2022

The purpose of this study is to study Gyobang dance and music in Honam region during the Joseon Dynasty. Except for Jeju Island, there were six Gyobangs in the Honam region: Namwon, Jeonju, Gwangju, Sunchang, Muju, and Suncheon. The dances that had been passed down to Gyobang in the Honam region are 11 events such as Jengmu, Pogorak, Seonyurak, Geommu, Heonbando, Cheoyongmu, Seungmu, Geommu, Hakdance, Abakmu, and Mudong. Kyobang’s music was handed down 19 songs.
The characteristics of Gyobang dance in Honam region are, first, Gyobang dance contains human joy and anger and contains an unrefined freedom. Second, Gyobang's music contains both calm and folk style. Third, the Gyobang dance of Honam influenced the culture of the Pungryu that harmonized with the nature of Honam.
Parental Phubbing and Adolescents’ Reactive Characteristics to Parents-Self - Centered Drawing (PSCD)
Authors:   The Korean Society of Culture and Convergence, Choi Seunghwan , Chung Youngin
Published: August 2022

This study explores the relationship between parental phubbing and adolescents’ reactive characteristics to Parents-Self-Centered Drawing (PSCD). The participants included 130 students from middle and high schools in Gyeonggi, Korea. We conducted chi-square tests to explore the differences in PSCD between the higher and lower parental phubbing groups. Results indicated that there were statistically significant differences in the omission of body parts, drawing order, positioning of figures and facial expressions for father figures between the higher and lower father phubbing groups. Second, there were statistically significant differences in the omission of body parts, drawing order for mother figures between the higher and lower mother phubbing groups. Third, we found significant differences in the omission of body parts, drawing order and facial expressions for self-figures between the groups according to father phubbing, while we found significant differences in the omission of body parts, drawing order and positioning of figures for self-figures between the groups according to mother phubbing. The findings of this study suggest that the possibility of PSCD as an indicator of parental phubbing for adolescents.
Analysis on Doping Mindset and Propensity of Domestic Athletes: Focusing on Whether to Have Doping Education and Punishment Perception
Authors:   The Korean Society of Culture and Convergence, Yang Gisuk
Published: August 2022

This study is designed to confirm differences on doping mindset and propensity considering demographic characteristic, whether to have doping education, whether to have doping punishment perception of domestic athletes. For this purpose, we selected 955 athletes as subject of study, and investigated doping mindset and propensity of athletes by using Performance Enhancement Attitude Scale as a research tool. As a result, first, it was found that there was a statistically significant difference in doping education depending on age, career, national team experience, and winning experience. Second, it was found that there was a statistically significant difference in punishment perception depending on age, career, national team experience, winning experience, and doping education. Third, it was found that there was a statistically significant difference in PEAS depending on age and doping education. It is judged that this result can be used as useful basic data in carrying out doping prevention of domestic athletes.
A Study on the Direction of Integrated Education of Korean Language and Korean Art Culture
Authors:   The Korean Society of Culture and Convergence, Cho Hangrok , Woo Seunghee
Published: August 2022

The purpose of this study is to suggest the way of integration education of Korean language and Korean art culture for Korean language learners. It deals with the genre and main factors of Korean art through a interdisciplinary research as the first step of it. It focuses on curricula, textbooks, and teaching activities to review how Korean art is being introduced into the current Korean language education. This study suggests 4 alternatives including conducting a survey for learner needs analysis and setting pluralistic educational goals for introducing Korean art into Korean language education. This study is an interdisciplinary research between Korean art and Korean language education. It will be meaningful as an attempt to find an integrated education plan for Korean language and Korean art in the era of academic convergence.
Study on Impact to Quality of Private Education Service on Satisfaction and Retaking Lectures’ Intention
Authors:   The Korean Society of Culture and Convergence, Seo Misoon , Yoon Byungseop , Chae Myungsin
Published: August 2022

Education is the area where social changes have to be reflected rapidly and accurately.
After the COVID-19 pandemic, it is necessary to increase public trust as high-quality education services beyond a role of supplement public education with the expectation and dependence of private education. In this study through empirical testing it specifically present quality of private education service and reveal that there is significant in customer satisfaction. In addition, there are differences in the relationship between satisfaction quality of educational service by customer types(students and parents), and quality of educational service has a positive effect on retaking classes.
Based on the results of this study, Furthermore, in order to increase customer satisfaction, it is necessary to lay groundwork for more beneficial capabilities for improving the quality of education services within private one.
A Study on Practical Direction and Strategy of a Growth-Oriented Mindset in Knowledge Information Age
Authors:   The Korean Society of Culture and Convergence, Jeon Jonghee
Published: August 2022

The purpose of this study is to specifically explore the practical direction and strategy of a growth -oriented mindset in the age of knowledge information. In a world full of external stimuli and heterogeneous demands, if an individual does not intend for a better direction on his own, he stays in a reactive being, rushing to deal with day-to-day issues, and it is difficult to realize and develop his own personality and potential. In this context, this study presented the practical direction and strategy of a growth-oriented mindset related to qualitative growth and learning goals that emphasize absolute standards and processes for oneself based on research on related literature and the latest issues. First, from a macroscopic point of view, the practical direction of the growth -oriented mindset includes ‘What is important after work is active change, not passive rest’, and ‘a life of making and executing a highlight for growth in an era where distraction is the default’. Next, from a microscopic point of view, the strategy for the growth-oriented mindset has from a microscopic point of view, ‘prioritize non-urgent but important tasks’, ‘start small and light and continue to change based on the brain plasticity’, ‘practice planned training towards excellence’, ‘practice the balance between real-time information and knowledge’, ‘cultivate the depth of extracting value from information’, ‘Developing depth by minimizing distraction’, ‘practice rituals and deep work’. It is hoped that this study will broadly share and spread the direction and practice strategy of a growth -oriented mindset that helps people fill the meaning and value of life in knowledge information age.
Sistem Navigasi Wall Following Robot Omnidirectional Dengan 4 Penggerak Mekanum Menggunakan PID Berbasis myRIO
Authors: Ramadhan Rizky , Siradjuddin Indrazno , Dewatama Denda
Published: August 2022

Intisari— Navigasi wall following merupakan salah satu sistem navigasi dengan cara mengikuti dinding. Tugas dari robot ini adalah mengikuti dinding sesuai dengan setpoint yang diberikan dengan cara mempertahankan jarak robot dengan dinding agar robot tetap dalam jarak aman dan tidak menyentuh dinding. Pada robot ini menggunakan sensor infrared sebagai masukan untuk mengukur jarak antara robot dengan dinding. Dimana nantinya data dari sensor diolah pada kontroller myRIO dengan menggunakan metode PID yang nantinya data keluarannya akan diolah lagi menggunakan inverse kinematic. Untuk keluaran dari robot ini adalah 4 buah motor mekanum. Robot ini menggunakan software LabVIEW untuk menampilkan dan mengatur PID, dimana PID yang diterapkan pada robot ini dapat membuat pergerakan robot ini lebih cepat dan stabil. Penentuan parameter kendali PID dalam penelitian ini diperoleh menggunakan 2 metode, yaitu ziegler Nichols dan trial and error, pada metode ziegler nichols didapatkan respon yang kurang baik, sehingga dilanjutkan menggunakan metode trial and error yang mendapatkan repon yang cepat dan stabil dengan nilai Kp = 1.5, dan Kd = 0.004
Alat Penentu Ukuran dan Stok Sepatu Otomatis Berbasis IoT (Internet of Things) Menggunakan ESP32
Authors: Aryasatya Waluyo Muhammad Titan , Siswoko Siswoko , Subiyantoro Subiyantoro
Published: August 2022

[1]         A. Hermawan, A. Muid, I. Nirmala, “Rancang Bangun Alat Ukur Panjang Kaki dan Penentu Stok Sepatu yang Tersedia Secara Digital Menggunakan Arduino Mega 2560 Berbasis Website”. Kumpulan Jurnal Ilmu Komputer (KLIK). Vol. 05, No. 02. September 2018.[2]         R. Firdaus, M.F. Wicaksono. M. Kom. “Alat Pengukur Ukuran Kaki untuk Pencarian Sepatu Berbasis Raspberry Pi”, Jurnal UNIKOM. 2018.[3]         M. Subiatno, H. Setiawan, dkk, “Rancang Bangun Prototipe Sistem Kontrol Penggunaan Air Prabayar Berbasis Arduino Uno”, STIKI Informatika Jurnal ,Vol. 8, No. 1, April 2018.[4]         Muliadi. Al Imran. Muh. Rasul. Pengenmbangan Tempat Sampah Pintar Menggunakan ESP32, Jurnal Media Elektrik Vol.17 No.2, April 2020.[5]         Arasada, Bakhtiyar. Suprianto, Bambang. Aplikasi Sensor Ultrasonik Untuk Deteksi Posisi Jarak Pada Ruang Menggunakan Arduino Uno. Jurnal Teknik Elektro. Vol.6, No. 2. 2017.[6]         A. Prayitno, dkk. “Pengaruh Brand Image, Lifestyle dan Promosi Terhadap Keputusan Pembelian Sepatu Ventela (Studi Kasus pada Konsumen Toko Gorilla Market Bululawang)”, E-Journal Manajemen Prodi Manajemen Fakultas Ekonomi dan Bisnis Unisma. Vol 10. No 15. 2021.[7]         K. Koloay, dkk. “Rancang Bangun Aplikasi Fitness Berbasis Android (Studi Kasus: Popeye Gym Suwaan)”, E-Journal Teknik Informatika Vol.5, No. 2. 2020.[8]         S. Surahman, dan E.B. Setiawan, “Aplikasi Mobile Driver Online Berbasis Android Untuk Perusahaan Rental Kendaraan”, Jurnal ULTIMA InfoSys. Vol. VIII, No.1. Juni 2017.[9]         G. H. Krisnawati, “Membangun Aplikasi Berbasis Android “Pembelajaraan Menggunakan APP Inventor”, Jurnal DASI. Vol.12, No.4. Desember 2011.[10]      Sunardi, dkk. “Analisis Application Programming Interface pada Mobile E-Voting menggunakan Metode Test-Driven Development, Jurnal TECHNO. Vol, 20. No.2. Oktober 2019.[11]      I. F. Maulana, “Penerapan Firebase Real Time Database pada Aplikasi E-Tilang Smartphone Berbasis Mobile Android”, Jurnal RESTI. Vol.4 No. 5. 2020.
Tumor de Buschke – Löwenstein
Authors: Leone Paolo , Carvajal Maria Fernanda
Published: August 2022

Introducción: El tumor de Buschke – Lowenstein (TBL) es enfermedad de transmisión sexual causada por el virus del papiloma humano (VPH), descrita como una forma intermedia entre un condiloma acuminado y un carcinoma de células escamosas. Afecta principalmente al área genital y anorrectal, posee capacidad de transformación maligna y una alta tasa de recurrencia. La cirugía es el tratamiento de primera línea.
Caso clínico: Presentamos el caso de un paciente masculino de 27 años con lesiones verrucosas de crecimiento progresivo en el área inguinal y genital. Mediante la correlación clínico-patológica se llegó al diagnóstico de TBL. Tras discusión en comité multidisciplinario se declaró irresecable y se resolvió tratamiento con radioterapia, además vacunación terapéutica contra el VPH, tanto sistémica como intralesional.
Conclusión: El TBL es localmente agresivo y de difícil tratamiento, por lo que la prevención contra el VPH es fundamental. La vacunación terapéutica en conjunto con la radioterapia ofreció mejoría clínica.
Prediction of fatigue crack propagation in metals based on IBAS-PF
Authors: Wensheng Su , Zhenhua Gu , Jiefei Gu , Zhigang Xue
Published: August 2022

Owing to particle leanness, the standard Particle Filter (PF) algorithm is prone to the problem of reduced prediction accuracy when predicting fatigue crack propagation. An improved particle filter algorithm based on the optimization algorithm of beetle antenna search (IBAS-PF) for fatigue crack propagation in metals is proposed in this paper. The discrete Paris formula was used to establish the state equation of fatigue crack propagation, in which the uncertainty of material and crack propagation process were considered. Meanwhile, the characteristics of Lamb wave signals under different crack lengths were extracted to establish the observation equation. The sampling process of the PF algorithm was optimized based on the beetle antennae search algorithm to improve the particle diversity and the prediction accuracy. Compared with the standard PF algorithm, the improved BASO-PF algorithm has higher accuracy for metal fatigue crack propagation, as well as better state estimation ability.
Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs
Authors: Lee Miyoung , Geitgey Delaney K. , Hamilton Jamie A. G. , Boss Jeremy M. , Scharer Christopher D. , Spangle Jennifer M. , Haynes Karmella A. , Henry Curtis J.
Published: August 2022

The world’s population with obesity is reaching pandemic levels. If current trends continue, it is predicted that there will be 1.5 billion people with obesity by 2030. This projection is alarming due to the association of obesity with numerous diseases including cancer, with recent studies demonstrating a positive association with acute myeloid leukemia (AML) and B cell acute lymphoblastic leukemia (B-ALL). Interestingly, several epidemiological studies suggest the converse relationship may exist in patients with T cell acute lymphoblastic leukemia (T-ALL). To determine the relationship between obesity and T-ALL development, we employed the diet-induced obesity (DIO) murine model and cultured human T-ALL cells in adipocyte-conditioned media (ACM), bone marrow stromal cell-conditioned media, stromal conditioned media (SCM), and unconditioned media to determine the functional impact of increased adiposity on leukemia progression. Whereas only 20% of lean mice transplanted with T-ALL cells survived longer than 3 months post-inoculation, 50%–80% of obese mice with leukemia survived over this same period. Furthermore, culturing human T-ALL cells in ACM resulted in increased histone H3 acetylation (K9/K14/K18/K23/K27) and methylation (K4me3 and K27me3) posttranslational modifications (PTMs), which preceded accelerated cell cycle progression, DNA damage, and cell death. Adipocyte-mediated epigenetic changes in human T-ALL cells were recapitulated with the H3K27 demethylase inhibitor GSK-J4 and the pan-HDAC inhibitor vorinostat. These drugs were also highly cytotoxic to human T-ALL cells at low micromolar concentrations. In summary, our data support epidemiological studies demonstrating that adiposity suppresses T-ALL pathogenesis. We present data demonstrating that T-ALL cell death in adipose-rich microenvironments is induced by epigenetic modifications, which are not tolerated by leukemia cells. Similarly, GSK-J4 and vorinostat treatment induced epigenomic instability and cytotoxicity profiles that phenocopied the responses of human T-ALL cells to ACM, which provides additional support for the use of epigenetic modifying drugs as a treatment option for T-ALL.
Clinical deployment environments: Five pillars of translational machine learning for health
Authors: Harris Steve , Bonnici Tim , Keen Thomas , Lilaonitkul Watjana , White Mark J. , Swanepoel Nel
Published: August 2022

Machine Learning for Health (ML4H) has demonstrated efficacy in computer imaging and other self-contained digital workflows, but has failed to substantially impact routine clinical care. This is no longer because of poor adoption of Electronic Health Records Systems (EHRS), but because ML4H needs an infrastructure for development, deployment and evaluation within the healthcare institution. In this paper, we propose a design pattern called a Clinical Deployment Environment (CDE). We sketch the five pillars of the CDE: (1) real world development supported by live data where ML4H teams can iteratively build and test at the bedside (2) an ML-Ops platform that brings the rigour and standards of continuous deployment to ML4H (3) design and supervision by those with expertise in AI safety (4) the methods of implementation science that enable the algorithmic insights to influence the behaviour of clinicians and patients and (5) continuous evaluation that uses randomisation to avoid bias but in an agile manner. The CDE is intended to answer the same requirements that bio-medicine articulated in establishing the translational medicine domain. It envisions a transition from “real-world” data to “real-world” development.
Morphometric Identification of Starch Granules From Archaeological Contexts: Diagnostic Characteristics of Seven Major North American Plant Families
Authors: Louderback Lisbeth A. , Wilks Stefania , Herzog Nicole M. , Brown Gloria Howat , Joyce Kaley , Pavlik Bruce M.
Published: August 2022

Starch-rich plants have played an important role in human evolution and societal development. Collected, grown, and consumed to support ever-increasing populations, such plants are integral to understanding past human diets. With the advent of starch granule analysis, plant resources that were invisible in the archaeological record can now be revealed in the cracks and crevices of artifacts. Widespread application of this technique, however, has stalled due to a lack of rigorous and standardized protocols. For example, taxonomic identification of starch granules using consistent diagnostic characteristics is still a challenge as there are no comprehensive surveys across important (i.e., dietary) plant taxa, especially at the levels of families, genera, and species. This study provides characteristics for identifying starch granules of seven major North American plant families (Amaranthaceae, Apiaceae, Fagaceae, Liliaceae, Pinaceae, Poaceae, and Solanaceae) based on systematic, morphometric studies of modern reference materials. A dichotomous key to starch granules of the seven families was also generated to aid in identification of those from archaeological contexts. Although we have focused on plants from western North America, these families occur across the globe and have had dietary significance throughout prehistory.
Experimental research on production law of multilayer heterogeneous reservoirs
Authors: Deng Xuan , Huang Xiaoliang , Ye Qing , Li Sainan , Yu Chengchao , Zhang Xu , Wang Zuohao
Published: August 2022

In the development of multi-layer co-production heterogeneous reservoirs, problems such as serious inter-layer heterogeneity and interference always exist, resulting in an unclear understanding of inter-layer production. A clear understanding of the interference mechanism and influence of main controlling factors of multi-layer heterogeneous reservoirs on the production of small layers is the key to the effective development of the reservoirs. On the basis of clarifying the main controlling factors affecting the production of multi-layer heterogeneous reservoirs, this paper developed a multi-pipe parallel displacement experiment system to carry out indoor heterogeneous reservoir multi-layer water injection flooding experiments. Combined with dynamic and static parameters, the experiments simulated and evaluated the effects of factors such as permeability ratio, water cut, shutting down high permeability layers, production pressure difference, and change in crude oil viscosity in high permeability layers. The primary objective of this work is to reveal the mechanism of small-layer interference under different conditions, and clarify the influence of main control factors on the production of small-layer. The results show that the smaller the permeability ratio is, the weaker the difference in physical properties among layers along the vertical direction is. The reduction in the difference in seepage resistance decreases the dynamic interference among layers. The reduction in the water ratio among layers and shutting down high permeability layers can reduce the interlayer interference effectively. Increasing production pressure difference effectively improves the oil displacement efficiency of reservoirs with poor physical properties. A lower fluidity in the high permeability layers can effectively improve the oil displacement efficiency of other layers.
Clinical and genetic characteristics of 29 Chinese patients with X-linked hypophosphatemia
Authors: Xu Tian , Tao Xiaohui , Zhang Zhenlin , Yue Hua
Published: August 2022

Objective

The aim of this study was to fully describe the clinical and genetic characteristics, including clinical manifestations, intact fibroblast growth factor 23 (iFGF23) levels, and presence of PHEX gene mutations, of 22 and 7 patients with familial and sporadic X-linked dominant hypophosphatemia (XLH), respectively.

Methods

Demographic data, clinical features, biochemical indicators, and imaging data of 29 patients were collected. All 22 exons and exon–intron boundaries of the PHEX gene were amplified by polymerase chain reaction (PCR) and directly sequenced. The serum level of iFGF23 was measured in 15 of the patients.

Results

Twenty-nine patients (male/female: 13:16, juvenile/adult: 15:14) with XLH were included. The main symptoms were bowed lower extremities (89.7%), abnormal gait (89.7%), and short stature/growth retardation (78.6%). Hypophosphatemia with a high alkaline phosphatase level was the main biochemical feature and the median value of serum iFGF23 was 55.7 pg/ml (reference range: 16.1–42.2 pg/ml). Eight novel mutations in the PHEX gene were identified by Sanger sequencing, including two missense mutations (p. Gln682Leu and p. Phe312Ser), two deletions (c.350_356del and c.755_761del), one insertion (c.1985_1986insTGAC), and three splice mutations (c.1700+5G>C, c.1966-1G>T, and c.350-14_350-1del). Additionally, the recurrence rate after the first orthopedic surgery was 77.8% (7/9), and five of them had their first surgery before puberty.

Conclusion

Our study expanded the clinical phenotypes and gene mutation spectrum of XLH and provided a reference for the optimal timing of orthopedic surgeries.
High-resolution estimation of air pollutant emissions from vegetation burning in China (2000–2018)
Authors: Yang Wei , Jiang Xiaoli
Published: August 2022

Vegetation burning in China contributes significantly to atmospheric pollution and climate change. However, most recent studies have focused on forest fires, ignoring grassland fires. Besides, there was a generally high uncertainty in the estimated fire emission because of missing small fire data and limited local vegetation data. This study employed high-resolution burned area data (GABAM, global annual burned area map) and land cover data to develop a high-resolution (30 m) emission inventory of vegetation burning in China in 2000, 2005, 2010, 2015, and 2018. Eleven pollutants were estimated, including CO, CH4, NOx, non-methane volatile organic carbon (NMVOC), SO2, NH3, PM2.5, PM10, organic carbon (OC), black carbon (BC), and CO2. The cumulative pollutant emissions from the temporal and spatial variation analyses of the burned area and emissions reached 1.21 × 105 Gg. Specifically, CO2 was the largest emission, with a mean annual emission of 2.25 × 104 Gg, accounting for 92.46% of the total emissions. CO was the second-largest emission, with a mean annual emission of 1.13 × 103 Gg. PM10 and PM2.5 emissions were also relatively high, with a mean annual emission of 200.5 and 140.3 Gg, respectively, with that of NMVOC (159.24 Gg) in between. The emissions of other pollutants, including OC, NOx, CH4, NH3, SO2, and BC, were relatively low. The South, Southwest, East, and Northeast of China contributed the most emissions. Shrubland contributed the most emissions for different vegetation types, followed by forest and grassland. Consequently, this study provides scientific evidence to support understanding the influence of fire on the local environment and policy on China’s air pollution control.
Maize diversification and nitrogen fertilization effects on soil nitrous oxide emissions in irrigated mediterranean conditions
Authors: Franco-Luesma Samuel , Lafuente Victoria , Alonso-Ayuso María , Bielsa Ana , Kouchami-Sardoo Iraj , Arrúe José Luis , Álvaro-Fuentes Jorge
Published: August 2022

Maize is a major irrigated crop in Mediterranean areas and its typical intensive management may impact soil nitrous oxide (N2O) emissions. In these irrigated continuous maize systems, the legumes incorporation as well as adjusted nitrogen (N) fertilization might be interesting strategies to reduce soil N2O emissions. The objective of this study was to assess the impact of cropping diversification and different N rates on soil N2O emissions in flooded irrigated maize under Mediterranean conditions. To achieve this, two cropping systems (maize monoculture system, MC; and pea -maize rotation, MP) and 3N rates (unfertilized, 0N; medium rate, MN; and high rate, HN) were evaluated in a field experiment established in NE Spain during 2 years (2019; 2020). During the studied period, the N rate had a significant effect on soil N2O emissions, with a non-linear positive response of cumulative soil N2O emissions to N rates. In both systems, quick and high increases of soil N2O fluxes were observed immediately after the N application reaching 55 and 100 mg N2O-N m−2 day−1 in MC and MP, respectively. Both years, the pea phase of the MP rotation showed greater cumulative N2O emissions than the fallow of MC. However, N2O losses in the maize phase were similar (2019) or even higher (2020) in MC than in MP. Moreover, in both seasons, the MN treatments showed lower yield-scaled N2O emissions and N emission factor than the HN treatments, being this last lower than 1% in all cases. The results obtained showed that in irrigated Mediterranean conditions the replacement of a fallow by a legume, together with an adjusted N fertilization are favourable strategies to mitigate soil N2O emissions in high-yielding maize systems.
Characterization and Risk Assessment of Heavy Metals in Surface Sediments From Jian and Moyang Rivers in Western Guangdong
Authors: Feng Jie , Lin Yuemin , Li Mingkun , Ouyang Tingping , Yu Mingjie
Published: August 2022

The river environment is complex and receives a variety of contaminants from numerous sources that are persistent, bioaccumulative, and toxic. The distribution, source, contamination, and ecological risk status of Zn, Pb, Cu, Ni, Cr, and Cd were evaluated in the surface sediments at 45 sites on the Moyang and Jian rivers in Western Guangdong, China. Single pollution indices, including contamination factor (CF) and enrichment factor (EF), revealed that Zn, Pb, Ni, Cu, and Cd showed moderate to significant enrichment. To overcome the limitation of the single element indices, a range of sediment quality indices, including modified contamination index (mCd), pollution index (PI), and modified pollution index (MPI), were utilized to ascertain the sediment quality. The sediment in the study area is deemed to be slightly to extremely polluted. The sediment quality guidelines (SQGs), potential ecological risk index (RI), and modified ecological risk index (MRI) were used to assess possible ecological risks. According to the SQGs, Pb, Ni, and Cu have the potential to induce biological effects. The RI indicated that the sediment poses a low ecological risk. However, the MRI indicated that the ecological risk of the sediment was moderate to very high. The accuracy of the single and multi-element indices and ecological risk assessment were evaluated in the river using the principal component analysis (PCA) and cluster analysis (CA), showing an anthropogenic impact. Results demonstrate the need to pay attention to the ecological environment of small rivers, which are sensitive to their surroundings.
Effects of rape/common vetch intercropping on biomass, soil characteristics, and microbial community diversity
Authors: Qu Jiahui , Li Lijun , Wang Ying , Yang Jinhu , Zhao Xinyao
Published: August 2022

Legume–brassica intercropping is widely used to increase productivity in modern, sustainable agricultural systems. However, few studies have assessed the linkages between soil properties and soil microorganisms. Soil microorganisms play a key role in soil nutrient turnover and plant community composition. To elucidate the responses of soil microbial community diversity and structure to intercropping, we conducted a 2-year experiment based on common vetch (CV) monoculture, rape (R) monoculture, and common vetch–rape intercropping (IRCV) with phosphorus (P) addition in alkaline soil. The microbial communities of bacteria and fungi in the rhizosphere soil were examined based on high-throughput sequencing targeting the 16S rRNA and ITS genes, respectively. In addition, we analyzed changes in soil properties and enzyme activities. Intercropping significantly increased dry matter (up to 98.86% and 81.48%, respectively dry matter is the aboveground biomass.) compared with common vetch monoculture. Intercropping decreased soil bulk density and pH and enhanced soil available phosphorus (AP) by 14.54–34.38%, 7.25–22.67%, soil organic matter (SOM) by 15.57–22.85, 6.82–15.57%, soil sucrase (Suc.) by 13.69–16.10%, 35.57–40.24% compared to monoculture common vetch and rape, respectively. However, bacterial alpha diversity was higher under rape monoculture than IRCV. In addition, the dominant soil bacterial phyla Proteobacteria (1.25–3.60%), Gemmatimonadetes (7.88–15.16%), Bacteroidetes (9.39–11.76%), and Rokubacteria (0.49–5.69%) were present at greater abundance with IRCV relative to those with CV and R, but phyla Chloroflexi was significantly decreased by 11.56–12.94% with IRCV compared with the other two treatments. The redundant analysis showed that SOM and AP were positively correlated with the dominant bacterial and fungal flora. Common vetch–rape intercropping resulted in increased biomass and altered soil microbial community composition as well as soil properties. Our results showed that intercropping systems positively improve soil microbial activity; this strategy could help in the cultivation of multiple crops and improve soil properties through sustainable production.
Estimating the energy saving potential of residential consumption in China based on decent living standards
Authors: Yu Yawen , Yang Jin , Chai Song , Tang Lin
Published: August 2022

The basic well-being of residents should be fully considered when making residential energy-saving policies. In this study, decent living standards for China were proposed. The provincial energy saving potential of Chinese residents were estimated from a lifetime perspective using environmental extended input–output analysis. The results show that, in 2017, the energy saving potential of Chinese residents constituted 32.74% of total energy consumption. The consumption categories of transportation, housing and cooking had the greatest energy saving potential of 1668.40, 3540.83 and 3229.75 trillion kJ, respectively, in which direct energy consumption accounted for 85% of total energy consumption. For food, clothing, water, health care and education, there was only energy saving potential from indirect consumption, of which food has the largest indirect energy consumption of 3159.25 trillion kJ. Moreover, the energy saving potential varied at the provincial level, coming from different consumption categories. Special attentions should be paid to the transportation in Beijing, housing in Liaoning, and cooking in Gansu, which have relatively greater energy saving potential with per capita energy saving potential of 207.38, 1002.16, and 4256.6 thousand kJ, respectively. The results verify the importance of differentiated and targeted energy policies for residential consumption in different provinces.
EV duty vehicles: Features and functions of ciliary extracellular vesicles
Authors: Vinay Ludovic , Belleannée Clémence
Published: August 2022

The primary cilium is a microtubule-based organelle that extends from a basal body at the surface of most cells. This antenna is an efficient sensor of the cell micro-environment and is instrumental to the proper development and homeostatic control of organs. Recent compelling studies indicate that, in addition to its role as a sensor, the primary cilium also emits signals through the release of bioactive extracellular vesicles (EVs). While some primary-cilium derived EVs are released through an actin-dependent ectocytosis and are called ectosomes (or large EVs, 350–500 nm), others originate from the exocytosis of multivesicular bodies and are smaller (small EVs, 50–100 nm). Ciliary EVs carry unique signaling factors, including protein markers and microRNAs (miRNAs), and participate in intercellular communication in different organism models. This review discusses the mechanism of release, the molecular features, and functions of EVs deriving from cilia, based on the existing literature.