bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis
Authors: Trajman Anete , Lachapelle-Chisholm Sophie , Zikos Théodora , Werneck Guilherme Loureiro , Benedetti Andrea
Published: July 2022

Background

There is consistent evidence that SARS-CoV-2 vaccines have statistical and clinical significant efficacy to prevent incident and severe cases of COVID-19, although different outcomes were analyzed and different risk reductions were observed. However, randomized control trials (RCT) were not designed or powered to assess whether the vaccines prevent deaths, even though this was a secondary or exploratory outcome across many studies. Early real-world observational data suggest that these vaccines are highly effective in reducing hospitalization and all-cause mortality. Our objective is to summarize and appraise—the existing evidence on the efficacy and real-world effectiveness of all SARS-CoV-2 vaccines currently approved for full or limited use to prevent all-cause and COVID-19-attributed mortality.

Methods

The population consists of persons with a record of vaccination status and the outcome of interest. Randomized controlled trials, comparative cohort and case-control studies reporting vaccination with any of the vaccines approved (intervention) will be eligible. The primary outcome will be all cause deaths. COVID-19-attributed deaths and deaths attributable to the vaccination (adverse event deaths) will be secondary outcomes. We will compare deaths occurring in vaccinated persons versus those non-vaccinated or having received placebo. Studies in any language will be eligible. Two independent reviewers will screen for inclusion and assess quality of studies using the Cochrane Risk of Bias 2 and the ROBINS-1 tool, as appropriate. Hazard ratios will be calculated. Assessment of statistical heterogeneity amongst the studies will be done using I2 and prediction intervals, as well as visual inspection of the forest plots. Publication bias will be assessed using a funnel plot and Egger statistical test if we have more than 10 studies in a forest plot. We have followed the PRISMA-Protocol checklist for the current protocol, which is registered at Prospero (York University, CRD42021262211).
Automatic Multi-functional Integration Program (AMFIP) towards all-optical mechano-electrophysiology interrogation
Authors: Luo Qin , Zhang Justin , Huang Miao , Lin Gaoming , Tanaka Mai , Lepler Sharon , Guan Juan , Siemann Dietmar , Tang Xin
Published: July 2022

Automatic operations of multi-functional and time-lapse live-cell imaging are necessary for the biomedical science community to study active, multi-faceted, and long-term biological phenomena. To achieve automatic control, most existing solutions often require the purchase of extra software programs and hardware that rely on the manufacturers’ own specifications. However, these software programs are usually non-user-programmable and unaffordable for many laboratories. To address this unmet need, we have developed a novel open-source software program, titled Automatic Multi-functional Integration Program (AMFIP), as a new Java-based and hardware-independent system that provides proven advantages over existing alternatives to the scientific community. Without extra hardware, AMFIP enables the functional synchronization of the μManager software platform, the Nikon NIS-Elements platform, and other 3rd party software to achieve automatic operations of most commercially available microscopy systems, including but not limited to those from Nikon. AMFIP provides a user-friendly and programmable graphical user interface (GUI), opening the door to expanding the customizability for myriad hardware and software systems according to user-specific experimental requirements and environments. To validate the intended purposes of developing AMFIP, we applied it to elucidate the question whether single cells, prior to their full spreading, can sense and respond to a soft solid substrate, and if so, how does the interaction depend on the cell spreading time and the stiffness of the substrate. Using a CRISPR/Cas9-engineered human epithelial Beas2B (B2B) cell line that expresses mNeonGreen2-tagged mechanosensitive Yes-associated protein (YAP), we show that single B2B cells develop distinct substrate-stiffness-dependent YAP expressions within 10 hours at most on the substrate, suggesting that cells are able to sense, distinguish, and respond to mechanical cues prior to the establishment of full cell spreading. In summary, AMFIP provides a reliable, open-source, and cost-free solution that has the validated long-term utility to satisfy the need of automatic imaging operations in the scientific community.
The impact of environmental and climate parameters on the incidence and mortality of COVID-19 in the six Gulf Cooperation Council countries: A cross-country comparison study
Authors: Saddik Basema , Awad Manal A. , Al-Bluwi Najlaa , Hussein Amal , Shukla Ankita , Al-Shujairi Arwa , AlZubaidi Hamzah , Al-Hajjaj Mohamed S. , Halwani Rabih , Hamid Qutayba
Published: July 2022

Background

Environmental factors can influence the epidemiological dynamics of COVID-19. To estimate the true impact of these factors on COVID-19, climate and disease data should be monitored and analyzed over an extended period of time. The Gulf Cooperation Council (GCC) countries are particularly lacking in such studies. This ecological study investigates the association between climate parameters and COVID-19 cases and deaths in the GCC.

Methods

Data on temperature, wind-speed and humidity and COVID-19 cases and deaths from the six countries of the GCC were collected between 29/1/2020 and 30/3/2021. Using Spearman’s correlation coefficient, we examined associations between climate parameters and COVID-19 cases and deaths by month, over four different time periods. A two-step cluster analysis was conducted to identify distinct clusters of data using climate parameters and linear regression analysis to determine which climate parameters predicted COVID-19 new cases and deaths.

Results

The United Arab Emirates (UAE) had the highest cumulative number of COVID-19 cases while Bahrain had the highest prevalence rate per 100,000. The Kingdom of Saudi Arabia (KSA) reported the highest cumulative number of deaths while Oman recorded the highest death rate per 100,000. All GCC countries, except the UAE, reported a positive correlation between temperature and cases and deaths. Wind speed was positively correlated with cases in Qatar, but negatively correlated with cases in the UAE and deaths in KSA. Humidity was positively correlated with cases and deaths in Oman, negatively correlated in Bahrain, Kuwait, Qatar and KSA but there was no correlation in the UAE. The most significant predictors in cluster analysis were temperature and humidity, while in the regression analysis, temperature, humidity and wind speed predicted new COVID-19 cases and deaths.

Conclusion

This study provides comprehensive epidemiological information on COVID-19 and climate parameters and preliminary evidence that climate may play a key role in the transmission of the COVID-19 virus. This study will assist decision makers in translating findings into specific guidelines and policies for the prevention and elimination of COVID-19 transmission and infection.
Lifestyle and socioeconomic determinants of diabetes: Evidence from country-level data
Authors: Richards Selena E. , Wijeweera Chandana , Wijeweera Albert
Published: July 2022

Objective

The objectives of the study is to investigate the global socioeconomic risk factors associated with diabetes prevalence using evidence from available country-level data.

Design

A cross-sectional study based on (2010 & 2019) countrywide Health Nutrition and Population Statistics data.

Population

People ages 20–79 who have diabetes.

Setting

One hundred and thirty-two countries or territories in the world.

Primary outcome measure

Diabetes prevalence rates were determined from (2010 & 2019) countrywide Health Nutrition and Population Statistics (Health Stats, World Bank Group).

Results

In 2010, a 1% increase in per capita income and total tobacco consumption is associated with a 0.92% (95% CI 0.64% to 1.19%) and 0.02% (95% CI 0.006% to 0.047%) increase in diabetes prevalence respectively; and a 1% increase in alcohol consumption is associated with a -0.85% (95% CI -1.17% to -0.53%) decrease in diabetes prevalence. Statistically significant socioeconomic and lifestyle indices positively associated with diabetes prevalence included gross national income; overweight prevalence (BMI>25 kg/m2); and tobacco consumption. Statistically significant inverse associations with global diabetes prevalence included total population size; unemployment and alcohol consumption. The 2019 data was removed due to sparsity of data.

Conclusion

Statistically significant global lifestyle and socioeconomic determinants of diabetes prevalence include alcohol consumption; tobacco consumption; overweight prevalence; per capita income; total population and unemployment rates. Determinants of diabetes include modifiable risk factors which are consistent at both the micro and macro level and include tobacco consumption and overweight prevalence. Factors which are non-modifiable and warrant further investigation include total population and unemployment rates, which were inversely associated with diabetes prevalence and are a product of other underlying factors. Other determinants such as alcohol consumption was also inversely associated with diabetes prevalence, but has been observed to have both negative and positive associations with diabetes at the micro-level. These associations were dependent upon the amount of alcohol consumed. Global cut-off point of alcohol consumption is critical to establish global policies to reduce diabetes prevalence. Overall, the use of cross-sectional based study for country level aggregate data is a critical tool that should be considered when making global joint strategies or policies against diabetes in both data analysis and decision making.
Home gardens of Central Asia: Reservoirs of diversity of fruit and nut tree species
Authors: Vinceti Barbara , Elias Marlène , Azimov Rashid , Turdieva Muhabbat , Aaliev Sagynbek , Bobokalonov Farhod , Butkov Evgeniy , Kaparova Elmira , Mukhsimov Nurullo , Shamuradova Svetlana , Turgunbaev Kubanichbek , Azizova Nodira , Loo Judy
Published: July 2022

Central Asia is an important center of origin for many globally valued fruit and nut tree species. Forest degradation and deforestation are cause for concern for the conservation of these valuable species, now confined to small remnant populations. Home gardens have the important function of sustaining household food consumption and income generation, and can potentially play a critical role in conserving diversity of fruit and nut trees. These systems have been very poorly documented in the scientific literature. This study contributes to filling this gap by describing the diversity of fruit and nut trees in home gardens of Kyrgyzstan, Uzbekistan, and Tajikistan, examining their dynamic flow of planting material and its sources, understanding their future prospects, and looking at significant differences between the three countries. Home gardens show a similar portfolio of the most abundant tree species (apple, apricot, walnut, pear, and plum). Although the diversity of tree species and varieties recorded is significant, small population sizes can limit future possibilities for this diversity to thrive, given the pressure on natural stands and on habitats where the preferred species are found. Furthermore, the selection of species and varieties to be planted in home gardens is increasingly influenced by market opportunities and availability of exotic material. Some of the most abundant tree species recorded are represented largely by exotic varieties (apple, pear), while others (e.g., apricot, walnut, plum) are still mainly characterized by traditional local varieties that are not formally registered. Home gardens continue to play a critical role in rural livelihoods and in national economies, and many rural inhabitants still aspire to maintain them. Thus, home gardens should be integrated in national research and extension systems and closely linked to national conservation efforts. Changes and possible declines in the diversity they host, their health status, and resilience should be carefully monitored.
Benefit of sequential bilateral cochlear implantation in children between 5 to 18 years old: A prospective cohort study
Authors: Kleijbergen W. J. , Sparreboom M. , Mylanus E. A. M. , de Koning G. , Helleman H. W. , Boermans P. P. B. M. , Frijns J. H. M. , Vroegop J. L. , van der Schroeff M. P. , Gelders E. E. J. , George E. L. J. , Lammers M. J. W. , Grolman W. , Stegeman I. , Smit A. L.
Published: July 2022

Objective

To determine the benefit of sequential cochlear implantation after a long inter-implantation interval in children with bilateral deafness receiving their second implant between 5 and 18 years of age.

Study design

Prospective cohort-study.

Setting

Tertiary multicenter.

Patients

85 children with bilateral deafness and unilateral implantation receiving a contralateral cochlear implant at the age of 5 to 18 years.

Method

The primary outcomes were speech recognition in quiet and noise (CVC) scores. The secondary outcomes were language outcomes and subjective hearing abilities, all measured before and 12 months after sequential bilateral cochlear implantation. Medians of the paired data were compared using the Wilcoxon signed-rank test. Univariable linear regression analyses was used to analyze associations between variables and performance outcomes.

Results

A significant benefit was found for speech recognition in quiet (96% [89–98] vs 91% [85–96]; p < 0.01) and noise (65% [57–75] vs 54% [47–71]; p = 0.01) in the bilateral CI condition compared to unilateral (n = 75, excluded 10 non-users). No benefit was seen for language outcomes. The subjective sound quality score was statistically significant higher in bilateral compared to the unilateral CI condition. Pre-operative residual hearing level in the ear of the second implant, the inter-implant interval and age at time of second implantation was not significantly associated with performance scores.

Conclusion

After 12 months of use, sequential bilateral cochlear implantation showed improved speech perception in quiet and noise and improved subjective sound quality outcomes in children despite a great inter-implantation interval (median of 8 years [range 1–16 years]).
Antifungal therapy in the management of fungal secondary infections in COVID-19 patients: A systematic review and meta-analysis
Authors: Sah Sujit Kumar , Shariff Atiqulla , Pathakamuri Niharika , Ramaswamy Subramanian , Ramesh Madhan , Undela Krishna , Srikanth Malavalli Siddalingegowda , Kumar Teggina Math Pramod
Published: July 2022

Objectives

The prevalence of fungal secondary infections among COVID-19 patients and efficacy of antifungal therapy used in such patients is still unknown. Hence, we conducted this study to find the prevalence of fungal secondary infections among COVID-19 patients and patient outcomes in terms of recovery or all-cause mortality following antifungal therapy (AFT) in such patients.

Methods

We performed a comprehensive literature search in PubMed®, Scopus®, Web of Sciences™, The Cochrane Library, ClinicalTrial.gov,MedRxiv.org,bioRxiv.org, and Google scholar to identify the literature that used antifungal therapy for the management fungal secondary infections in COVID-19 patients. We included case reports, case series, prospective & retrospective studies, and clinical trials. Mantel Haenszel random-effect model was used for estimating pooled risk ratio for required outcomes.

Results

A total of 33 case reports, 3 case series, and 21 cohort studies were selected for final data extraction and analysis. The prevalence of fungal secondary infections among COVID-19 patients was 28.2%. Azoles were the most commonly (65.1%) prescribed AFT. Study shows that high survival frequency among patients using AFT, received combination AFT and AFT used for >28 days. The meta-analysis showed, no significant difference in all-cause mortality between patients who received AFT and without AFT (p = 0.17), between types of AFT (p = 0.85) and the duration of AFT (p = 0.67).

Conclusion

The prevalence of fungal secondary infections among COVID-19 patients was 28.2%. The survival frequency was high among patients who used AFT for fungal secondary infections, received combination AFT and AFT used for >28 days. However, meta-analysis results found that all-cause mortality in COVID-19 patients with fungal secondary infections is not significantly associated with type and duration of AFT, mostly due to presence of confounding factors such as small number of events, delay in diagnosis of fungal secondary infections, presence of other co-infections and multiple comorbidities.
Cryptanalysis and improved mutual authentication key agreement protocol using pseudo-identity
Authors: Jo Hyang-Rim , Pak Kyong-Sok , Kim Chung-Hyok , Zhang Il-Jin
Published: July 2022

The authentication key agreement is a scheme that generates a session key for encrypted communication between two participants. In the authentication key agreement, to provide the mutual authentication and the robust session key agreement is one of the important security requirements to enhance the security performance of key agreement. Recently Zhou et al. had proposed the key agreement protocol using pseudo-identifiers, but we found that there were weaknesses in their protocol. We have demonstrated that Zhou et al.’s protocol is vulnerable to replay attack, fails to provide mutual authentication, no key control, re-registration with the original identifier and efficiency in the verification of wrong password. We improved their scheme and proposed an improved authentication key agreement protocol that provides robust mutual authentication and the secure session key agreement. We analyzed its security performance using BAN logic and AVISPA tools and compared computational cost, communication overhead and security properties with other related schemes.
Information loss and bias in likert survey responses
Authors: Westland J. Christopher
Published: July 2022

Likert response surveys are widely applied in marketing, public opinion polls, epidemiological and economic disciplines. Theoretically, Likert mapping from real-world beliefs could lose significant amounts of information, as they are discrete categorical metrics. Similarly, the subjective nature of Likert-scale data capture, through questionnaires, holds the potential to inject researcher biases into the statistical analysis. Arguments and counterexamples are provided to show how this loss and bias can potentially be substantial under extreme polarization or strong beliefs held by the surveyed population, and where the survey instruments are poorly controlled. These theoretical possibilities were tested using a large survey with 14 Likert-scaled questions presented to 125,387 respondents in 442 distinct behavioral-demographic groups. Despite the potential for bias and information loss, the empirical analysis found strong support for an assumption of minimal information loss under Normal beliefs in Likert scaled surveys. Evidence from this study found that the Normal assumption is a very good fit to the majority of actual responses, the only variance from Normal being slightly platykurtic (kurtosis ~ 2) which is likely due to censoring of beliefs after the lower and upper extremes of the Likert mapping. The discussion and conclusions argue that further revisions to survey protocols can assure that information loss and bias in Likert-scaled data are minimal.
Determinants of time to full enteral feeding achievement among infants with birth weight 1000-2000g admitted to the neonatal intensive care unit of public hospitals in Hawassa city, Sidama region Ethiopian, 2019: A retrospective cohort study
Authors: Tewoldie Melese Tikusie , Girma Meron , Seid Haider
Published: July 2022

Background

Nutritional care during the neonatal period is a cornerstone towards achieving optimal care. However, very limited data is available on optimizing parenteral and enteral nutrition that directly affects infant survival among Ethiopian neonates. Therefore, the objective of this study is to identify determinants of time to full enteral feeding achievement among low-birth-weight neonates admitted to neonatal intensive care units of public hospitals in Hawassa city.

Methods

A facility-based retrospective cohort study was conducted in Adare general hospital and Hawassa University’s comprehensive specialized hospital from August 2018 to 2019. Charts of infants with a birth weight of 1000-2000g (n = 273) neonates who were admitted to the neonatal intensive care unit (ICU) were reviewed. The sample size for each hospital was allocated proportionally and subjects were selected by using a simple random sampling technique. Data were entered using Epi. data version 3.1, and analysis was performed using SPSS version 20. Kaplan-Meier estimator and a Cox proportional hazard model were used.

Result

The mean (SD) age when an enteral feed (trophic feeding) was first commenced was 2.13(1.373) days. The median time to achieve full enteral feeding was 8 days with IQR (7–10 days). Gestational age reduces the time to full enteral feeding by 18.8% for each additional week of gestation (AHR = 0.812, p-value = 0.003). The time to achieve full enteral feeding was shorter by 70.4% among neonates who were small for gestational age, as compared with that appropriate for gestational age (AHR = 0.296, p-value<0.001).

Conclusion

According to this study, the time that the neonate takes to achieve full enteral feeding was relatively short. Gestational age and weight for gestational were the determinants for time to full enteral feeding achievement. Further research needs to be conducted to explore further, in addition to current findings.
LDL retention time in plasma can be -based on causation- estimated by the lipid composition of LDL and other lipoproteins
Authors: Jansen Martin , Contini Christine
Published: July 2022

Introduction

Information on LDL’s dynamic behaviour of LDL (i.e. production rate and fractional catabolic rate) are of interest if pathologies, lipid-lowering strategies or LDL-metabolism itself are investigated. Determination of these rates is costly and elaborate. Here we studied the interrelationship of LDL mass, its composition and other lipoproteins. Based on this data, we deducted information about LDL’s dynamic behaviour.

Methods

Lipoprotein profiles of n = 236 participants are evaluated. Plasma was separated by sequential ultracentrifugation into VLDL, IDL, LDL and HDL. Additionally, LDL and HDL were separated into subfractions. Stepwise multiple linear regressions were used to study LDL’s ApoB mass and lipid composition. Relying on these results and on causation, we constructed a mathematical model to estimate LDL’s retention time.

Results

The ApoB mass in LDL correlated best among all measured parameters (including corresponding lipid compositions but using no LDL-associated parameters) with the cholesterol ester content in IDL. TG/CE ratios in LDL’s subfractions were strongly correlated with the corresponding ratios in IDL and HDL. The constructed mathematical model links the TG/CE ratio of LDL and HDL to LDL’s ApoB concentration and enables a good estimate of LDL’s retention time in plasma.

Discussion

Relying on our statistic evaluations, we assume that i) the production of nascent LDL via IDL as well as ii) LDL’s prolonged retention are mapped by the TG/CE ratio in LDL subfractions. HDL’s TG/CE ratio is associated with the change in LDL’s TG/CE ratio during its retention in plasma. Our mathematical model uses this information and enables–by relying on causation- a good estimation of LDL’s retention time.
Fear of Covid 19 during the third wave of infection in Norwegian patients with type 1 diabetes
Authors: Ueland Grethe Åstrøm , Ernes Tony , Vonheim Madsen Tone , Husebye Eystein Sverre , Sandberg Sverre , Fjell Løvaas Karianne , Cooper John Graham
Published: July 2022

Objective

To study the fear of Covid 19 infection among Norwegian patients with type 1 diabetes.

Research design and methods

Fear of Covid 19 scale, a validated scale assessing the fear of Covid 19, was sent electronically to 16255 patients with type 1 diabetes in May 2021. The items are rated on a scale from 1 to 5 (total scores from 7 to 35). The higher the score, the greater the fear.

Results

10145 patients, 52% of the Norwegian adult type 1 diabetes population, completed the questionnaire. The mean total fear score was 13.8 (SD 5.8). Women experienced more fear than men (OR 1.96), and fear increased significantly with increasing age for both genders (p<0.05). Fear increased with increasing BMI, more pronounced for men than women. Fear was positively correlated to HbA1c (Spearman rho 0.067, p<0.05), and significantly increased in patients with micro- and macrovascular complications, compared with patients without complications (p<0.05). Smokers showed increased fear compared with non-smokers, (1.59 (1.39–1.81)), and non-European patients reported more fear than Europeans (OR of 2.02 (95% CI 1.55–2.63).

Conclusion

Assessment of fear of Covid 19 in the type 1 diabetes population in Norway revealed an overall low fear during the third wave of infection. Patients considered to be at high risk of serious disease, such as older individuals, smokers and obese individuals expressed more fear than low risk individuals. The degree of fear was also associated with sex, ethnicity, educational/working status, glycemic control and presence of complications.
Urgent air transfers for acute respiratory infections among children from Northern Canada, 2005–2014
Authors: Prendergast Caitlin , Robinson Joan , Caya Chelsea , Perez Trejo Maria E. , Guan Iline , Hébert-Murakami Veronica , Marianayagam Justina , Wong Zing-Wae , Walker Celia , Goldfarb David M. , Barrowman Nick , Jetty Radha , Embree Joanne , Papenburg Jesse
Published: July 2022

Background

The incidence of hospitalizations for acute respiratory infections (ARI) among young Indigenous children from Northern Canada is consistently high. ARIs requiring urgent air transfer can be life-threatening and costly. We aimed to describe their epidemiology, estimate age-specific incidences, and explore factors associated with level of care required.

Methods

We undertook a retrospective cohort study of children <5 years old from Northern Canada transferred by urgent air transport for ARI from 2005 through 2014 to 5 pediatric tertiary care centers in Vancouver, Edmonton, Winnipeg, Ottawa and Montreal. Admissions were identified via ARI-related ICD-9/10 coding and forward sortation area. Descriptive statistics and univariable analyses were performed.

Results

Among 650 urgent air transfers, the majority were from Nunavut (n = 349, 53.7%) or Nunavik (n = 166, 25.5%), <6 months old (n = 372, 57.2%), and without underlying comorbidity (n = 458; 70.5%). Estimated annual tertiary care ARI admission rates in infants <1 year old from Nunavut (40.7/1000) and Nunavik (44.5/1000) were tenfold higher than in children aged 1 to 4 years. Bronchiolitis (n = 333, 51.2%) and pneumonia (n = 208, 32.0%) were the most common primary discharge diagnoses. Nearly half required critical care (n = 316, 48.6%); mechanical ventilation rates ranged from 7.2% to 55.9% across centres. The most common primary pathogen was respiratory syncytial virus (n = 196, 30.1%). Influenza A or B was identified in 35 cases (5.4%) and vaccine-preventable bacterial infections in 27 (4.1%) cases.

Interpretation

Urgent air transfers for ARI from Northern Canada are associated with high acuity. Variations in levels of care were seen across referral centers, age groups and pathogens.
Policies on mental health in the workplace during the COVID-19 pandemic: A scoping review
Authors: Villarreal-Zegarra David , Reátegui-Rivera C. Mahony , Sabastizagal-Vela Iselle , Burgos-Flores Miguel Angel , Cama-Ttito Nieves Alejandra , Rosales-Rimache Jaime
Published: July 2022

Background

The COVID-19 pandemic has had a profound impact on both mental health and working conditions. Workplaces are conducive spaces for implementing strategies and interventions to promote mental health. In addition to this, they are preventing, identifying, and managing mental disorders effectively. Although international agencies have identified some guidelines for the management of mental health in the workplace in the context of the COVID-19 pandemic, a more precise characterization of both the components of the policies, their implementation, and evidence of the outcome is required to provide useful information for decision-makers.

Objectives

This study aims to synthesize scientific information regarding national and local policies focusing on preventing or improving, directly or indirectly, mental health problems in the workplace during COVID-19 pandemic.

Methods

Our study is a scoping review. The Scopus, Web of Science, and Embase databases and PubMed search engine were used. Original and reviewed articles published from January 1, 2020 to October 14, 2021 were included in the research. Articles with abstract or full text in English, Spanish, German and Portuguese were also included. Our strategy is based on identifying policies (intervention) which focuses on directly or indirectly preventing or ameliorating mental health problems in the workplace during COVID-19 pandemic (participants).

Results

A total of 6,522 records were identified, and only four studies were included in the scoping review, which were of low quality. That is, we found limited evidence evaluating mental health policies using primary or secondary data (empirical evaluation). Among the policies that have been identified are the increase of mental health resources, the promotion of mental health and self-care support programs, and the reduction of barriers to access to mental health treatment.

Conclusion

Our research finds that there is limited evidence available to evaluate national and local policies aimed at directly or indirectly preventing or ameliorating mental health problems at work during COVID-19 pandemic. This forces decision-makers to use different criteria to guide the allocation of resources and budgets. Therefore, there is a need for health intelligence teams in health systems to be able to assess the impact of policies as an important input for decision-makers.
Correlation of the antibacterial activity of commercial manuka and Leptospermum honeys from Australia and New Zealand with methylglyoxal content and other physicochemical characteristics
Authors: Green Kathryn J. , Lawag Ivan L. , Locher Cornelia , Hammer Katherine A.
Published: July 2022

Variation in the antibacterial potency of manuka honey has been reported in several published studies. However, many of these studies examine only a few honey samples, or test activity against only a few bacterial isolates. To address this deficit, a collection of 29 manuka/Leptospermum honeys was obtained, comprising commercial manuka honeys from Australia and New Zealand and several Western Australian Leptospermum honeys obtained directly from beekeepers. The antibacterial activity of honeys was quantified using several methods, including the broth microdilution method to determine minimum inhibitory concentrations (MICs) against four species of test bacteria, the phenol equivalence method, determination of antibacterial activity values from optical density, and time kill assays. Several physicochemical parameters or components were also quantified, including methylglyoxal (MGO), dihydroxyacetone (DHA), hydroxymethylfurfural (HMF) and total phenolics content as well as pH, colour and refractive index. Total antioxidant activity was also determined using the DPPH* (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric reducing–antioxidant power) assays. Levels of MGO quantified in each honey were compared to the levels stated on the product labels, which revealed mostly minor differences. Antibacterial activity studies showed that MICs varied between different honey samples and between bacterial species. Correlation of the MGO content of honey with antibacterial activity showed differing relationships for each test organism, with Pseudomonas aeruginosa showing no relationship, Staphylococcus aureus showing a moderate relationship and both Enterococcus faecalis and Escherichia coli showing strong positive correlations. The association between MGO content and antibacterial activity was further investigated by adding known concentrations of MGO to a multifloral honey and quantifying activity, and by also conducting checkerboard assays. These investigations showed that interactions were largely additive in nature, and that synergistic interactions between MGO and the honey matrix did not occur.
Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/core genes
Authors: Hong Xupeng , Menne Stephan , Hu Jianming
Published: July 2022

Hepadnaviruses use extensively overlapping genes to expand their coding capacity, especially the precore/core genes encode the precore and core proteins with mostly identical sequences but distinct functions. The precore protein of the woodchuck hepatitis virus (WHV) is N-glycosylated, in contrast to the precore of the human hepatitis B virus (HBV) that lacks N-glycosylation. To explore the roles of the N-linked glycosylation sites in precore and core functions, we substituted T77 and T92 in the WHV precore/core N-glycosylation motifs (75NIT77 and 90NDT92) with the corresponding HBV residues (E77 and N92) to eliminate the sequons. Conversely, these N-glycosylation sequons were introduced into the HBV precore/core gene by E77T and N92T substitutions. We found that N-glycosylation increased the levels of secreted precore gene products from both HBV and WHV. However, the HBV core (HBc) protein carrying the E77T substitution was defective in supporting virion secretion, and during infection, the HBc E77T and N92T substitutions impaired the formation of the covalently closed circular DNA (cccDNA), the critical viral DNA molecule responsible for establishing and maintaining infection. In cross-species complementation assays, both HBc and WHV core (WHc) proteins supported all steps of intracellular replication of the heterologous virus while WHc, with or without the N-glycosylation sequons, failed to interact with HBV envelope proteins for virion secretion. Interestingly, WHc supported more efficiently intracellular cccDNA amplification than HBc in the context of either HBV or WHV. These findings reveal novel determinants of precore secretion and core functions and illustrate strong constraints during viral host adaptation resulting from their compact genome and extensive use of overlapping genes.
Climate change resilient agricultural practices: A learning experience from indigenous communities over India
Authors: Aich Amitava , Dey Dipayan , Roy Arindam
Published: July 2022

The impact of climate change on agricultural practices is raising question marks on future food security of billions of people in tropical and subtropical regions. Recently introduced, climate-smart agriculture (CSA) techniques encourage the practices of sustainable agriculture, increasing adaptive capacity and resilience to shocks at multiple levels. However, it is extremely difficult to develop a single framework for climate change resilient agricultural practices for different agrarian production landscape. Agriculture accounts for nearly 30% of Indian gross domestic product (GDP) and provide livelihood of nearly two-thirds of the population of the country. Due to the major dependency on rain-fed irrigation, Indian agriculture is vulnerable to rainfall anomaly, pest invasion, and extreme climate events. Due to their close relationship with environment and resources, indigenous people are considered as one of the most vulnerable community affected by the changing climate. In the milieu of the climate emergency, multiple indigenous tribes from different agroecological zones over India have been selected in the present study to explore the adaptive potential of indigenous traditional knowledge (ITK)-based agricultural practices against climate change. The selected tribes are inhabitants of Eastern Himalaya (Apatani), Western Himalaya (Lahaulas), Eastern Ghat (Dongria-Gondh), and Western Ghat (Irular) representing rainforest, cold desert, moist upland, and rain shadow landscape, respectively. The effect of climate change over the respective regions was identified using different Intergovernmental Panel on Climate Change (IPCC) scenario, and agricultural practices resilient to climate change were quantified. Primary results indicated moderate to extreme susceptibility and preparedness of the tribes against climate change due to the exceptionally adaptive ITK-based agricultural practices. A brief policy has been prepared where knowledge exchange and technology transfer among the indigenous tribes have been suggested to achieve complete climate change resiliency.
Ecofeminismo: una filosofía para la postpandemia
Authors: Ruiz Pérez Nieves
Published: July 2022

El propósito del presente artículo es poner de relieve la filosofía ecofeminista en el contexto actual de crisis sanitaria y ecológica. Desde la hipótesis de que cada vez es más evidente la necesidad de un cambio de paradigma epistemológico para afrontar la cuestión del calentamiento global y, con ello, reducir las posibilidades de nuevos brotes pandémicos, se pretende argumentar por qué debería darse ese nuevo paradigma, bajo qué condiciones, cómo ha de ser esa transición y, sobre todo, qué tiene que ofrecer el ecofeminismo en esa transformación social. El ecofeminismo se presenta como una filosofía que busca eliminar de la episteme humana las estructuras de dominio y explotación dada entre los propios seres humanos (androcentrismo) y entre el ser humano y la naturaleza (antropocentrismo). Estas estructuras de pensamiento están fomentadas y naturalizadas por sistemas culturales como el patriarcado y, desde un punto de vista mercantil y más reciente, el capitalismo. Este sistema dual vertebra las sociedades actuales cada vez más globalizadas. Se está demostrando que esta manera de ver el mundo amenaza seriamente la vida en este planeta. La humanidad tiene la llave para minimizar las consecuencias de esta grave crisis ecológica sin punto de retorno. Así pues, este artículo defiende la idea de que cambiar de rumbo es algo imperativo y que el ecofeminismo nos proporciona las herramientas oportunas de respeto al otro, igualdad y sostenibilidad para que eso sea posible.
Reflexiones intempestivas. Género, afectos y pandemia
Authors: Romano Alejandra
Published: July 2022

Dentro de la próxima historia futura que se escriba de nuestros tiempos, la pandemia del COVID-19 será sin dudas un punto de inflexión en el relato histórico así como también de sus representaciones temporales colectivas apenas iniciado el siglo XXI, dado que la experiencia de la dilatación temporal que produjo el virus ─materializada en una cuarentena obligatoria a nivel mundial─ develó las estructuras artificiales y conflictivas de un presente ‘exitoso’ cimentado en su presupuesto evolutivo (Premat, 2016), sobre el cual la narrativa oficial del capitalismo moderno pretendió naturalizar una continuidad armoniosa y, paradójicamente, ahistórica, de la tríada pasado-presente-futuro. Una narrativa que, además, tradicionalmente configuró en sus esquemas explicativos la supremacía de la cronología, la linealidad del tiempo, y su avance sistemáticamente controlado como un orden progresivo, instalando un determinado régimen de historicidad presentista (Hartog, 2003) como único imaginario posible del tiempo en la modernidad actual para vivir, y por tanto, para narrar. En este sentido, pretendemos analizar en este trabajo el ensayo Borrador para un abecedario del desacato (2021) de Vir Cano como una apuesta literaria por la búsqueda y la exploración de relatos pandémicos insubordinados al régimen temporal vigente. De esta manera, analizaremos las modulaciones posibles de una temporalidad disidente a las temporalidades presentistas de la época contemporánea a partir de un libro originado y producido en el mismo momento del acontecimiento global del coronavirus. Así, postulamos dicha escritura como una ficción inactual y una escritura intempestiva que opera desde los márgenes de la literatura para producir fisuras en el presente desde el lenguaje y desde el cuerpo mismo del relato. El abordaje metodológico de la obra literaria se hará, por tanto, desde un análisis retórico textual, dado que sus herramientas permitirán poner de manifiesto los procedimientos discursivos del artificio utilizados por Cano, tales como el palimpsesto o el desacato alfabético del diccionario, y señalar en sus modos de operación narrativa, a la vez, el trazado de un imaginario que guarda la potencia —tanto de sus desvíos como de sus repeticiones— de otras lenguas y otros tiempos posibles.
Difference in cytological findings of healthy and conjunctivitis/keratoconjunctivitis affected canine eyes between variably experienced evaluators
Authors: Berzina Inese , Terentjeva Anastasija , Kovalcuka Liga
Published: July 2022

Background and Aim: Cytology investigations are a frequent part of ophthalmological examination. We aimed to assess whether the cytological findings of healthy and conjunctivitis/keratoconjunctivitis samples differed based on the evaluator's experience.

Materials and Methods: A study evaluated healthy eyes (n = 40) and eyes affected with keratoconjunctivitis and/ or conjunctivitis (n = 28) in dogs. An ophthalmological examination was performed before sampling the eyes using a sterile cotton swab. An evaluator with theoretical experience and one with undergone clinical pathology residency training performed cytology blinded to the clinical findings.

Results: In the healthy eyes group, the agreement between the evaluators for cellularity was nonexistent, while that for cell preservation and mucus content was fair. In the affected eyes group, the agreement for cellularity and mucus content was moderate, while that for cell preservation was fair. The inadequate sample rate differed significantly between the two evaluators in the healthy eyes group (p = 0.006) but not in the affected eyes group (p = 0.083). Bacterial presence was detected by both evaluators, and the findings did not differ statistically from the bacteriology results (p = 0.05). Significant variations were noted in the differential cell count; the mean count of the superficial epithelial cells and goblet cells of the healthy eyes group (p < 0.05) and that of the basal/intermediate cells and neutrophils of the affected eyes (p < 0.05) showed significant differences.

Conclusion: The evaluator's experience significantly affected the differential cell count in both the healthy and affected eyes groups. Neutrophil degeneration was not observed by the less experienced evaluator, whereas bacteria were detected equally well by both the evaluators.
They Spoke in Defense of Roy Moore: Networked Apologia and Media Ecosystems
Authors: Justice Jacob , Bricker Brett
Published: July 2022

CONTENT WARNING: This article contains discussion of sexual misconduct and quotations from individuals minimizing sexual misconduct.
One God, the Father
Authors: Branson Beau
Published: July 2022

The doctrine of “the Monarchy of the Father” is affirmed by nearly all patristic authors at the source of the doctrine of the Trinity and its canonical, creedal formulation(s). Yet, while still discussed by theologians, the doctrine has been (almost) completely ignored in analytic theology. I argue that the doctrine, though ancient, suggests a fresh approach within the contemporary debate, and reveals a fatal flaw in one of the strongest contemporary arguments against Trinitarianism. Briefly, whereas Social Trinitarianism identifies God with all of the divine persons (taken together) and Relative Identity Trinitarianism identifies God with each of the divine persons (taken individually), what I will call “Monarchical Trinitarianism” identifies God with one of the divine persons (the Father), without rejecting the full divinity of the Son and Spirit. According to Dale Tuggy, all orthodox formulations of the doctrine of the Trinity, by definition, identify God with the Trinity, rather than the Father, whereas the New Testament does the reverse. I argue Tuggy's argument counts equally in favor of Monarchical Trinitarianism, but siphons off that support, counting it as support only for Unitarianism via his definitions, which are undermined by a close reading of both patristic and modern Trinitarian theologians.
Sensitivity analysis of the concentration transport estimation in a turbulent flow
Authors: Kolyukhin Dmitriy , Sabelfeld Karl K. , Dimov Ivan
Published: July 2022

The present study addresses the sensitivity analysis of particle concentration dispersion in the turbulent flow. A stochastic spectral model of turbulence is used to simulate the particle transfer. Sensitivity analysis is performed by estimations of Morris and Sobol indices. This study allows to define the significant and nonsignificant model parameters. It also gives an idea of the qualitative behavior of the stochastic model used.
Acute aerobic exercise and attentional focus influence the self-positivity bias in emotional evaluation. Evidence from an experimental study
Authors: Meixner Friedrich , Herbert Cornelia
Published: July 2022

The influence of aerobic exercise, as a possibly mood-enhancing experience, was investigated for its effect on emotional evaluation of self- vs. other-related emotional (e.g., my/his joy) or neutral (e.g., my/his notes) stimuli. N=30 participants (healthy, female novices, i.e., with no regular, dedicated training schedule) performed four separate sessions of moderate aerobic exercise (22 min of cycling at 60-70% HRmax). Attentional focus was manipulated across exercise bouts (internal focus vs. external focus vs. no instructed attention focus vs. control condition consisting of no exercise and no instructed attention focus). Emotional evaluation of verbal stimuli was assessed 10 minutes after each exercise bout. Exercise increased self-reported positive affect compared to the inactive control condition regardless of attentional focus. Exercising without instructed attentional focus led to faster reaction times in the emotional evaluation task compared to the inactive control condition. Instructed internal or external attentional focus did not affect evaluations (number of valence-congruent responses) or reaction times compared to the no-exercise control condition. Self-reported internal attentional focus during cycling was associated with a subsequently stronger, and in the case of an external focus with a subsequently rather reduced self-positivity bias in the evaluation of self-related, positive vs. other-related positive words.