bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation of Microstructural and Mechanical Properties With Respect to Polarity in Shielded Metal Arc Welding of Mild Steel
Authors: Khamari Bijaya Kumar , Gunji Balamurali , Karak Swapan Kumar , Biswal Bibhuti Bhusan
Published: March 2019

Welding has been done by taking mild steel as work piece material in shielded metal arc welding (SMAW) process. Material thickness and current were considered as input parameters. Joining of metals has been completed in two ways. In first process double pass welding has been done in which 1st pass was in reverse polarity and the second pass was in straight polarity and in the 2nd process both the passes of welding were completed with straight polarity. The comparison of microstructure and impact toughness has been investigated. It was found that more amount of heat was generated in the 2nd process as compared to the 1st process. Therefore, growths of grains in heat affected zone occurred and maximum growth occurred in 2nd than 1st process. Impact strength increased with decrease in current value and increase in material thickness respectively. The impact strength values for 1st process welding were relatively less as compared to 2nd process.
Propuesta fenomenológica hermenéutica para el abordaje del trastorno límite de personalidad. Un abordaje desde los planteamientos teóricos de Heidegger, Gadamer, Längle, Ricoeur, Merleau-Ponty y Arciero
Authors: Pacheco Pacheco Cristóbal Andres
Published: March 2019

El presente trabajo, tuvo por objetivo diseñar un modelo de intervención psicoterapéutico desde las tradiciones de la fenomenología y la hermenéutica para el tratamiento del trastorno límite de personalidad (TLP). Para el desarrollo del mismo se realizó una extensa revisión teórica en temas asociados a fenomenología, fenomenología clínica, hermenéutica y trastorno límite de la personalidad, para finalmente establecer una propuesta que combina elementos epistemológicos asociados a la fenomenología-hermenéutica, utilizando como base los planteamientos de autores tales como Alfried Längle, Paul Ricoeur, Maurice Merleau-Ponty y Giampiero Arciero. El presente trabajo considera la necesidad de evaluar los beneficios asociados a la implementación del presente modelo en pacientes con TLP, estableciendo además una pregunta asociada a la definición de elementos formativos con los cuales debe contar un terapeuta fenomenológico-hermenéutico.
Dos Modelos de Crisis Suicida. Una Perspectiva Psicológica
Authors: García Haro Juan Manuel , González González Marta , García-Pascual Hernar
Published: March 2019

Resumen. La problemática suicida es sin duda una de las más difíciles para el clínico. En la ayuda a personas con riesgo suicida se camina muchas veces a tientas desprovistos de un esquema conceptual que sirva a explicar-comprender dicha conducta. Ahora bien, sin un entendimiento de la experiencia y de la conducta suicida, difícilmente se podrá dar una ayuda que sea efectiva, por mucho que la investigación apunte a diversos parámetros biomédicos supuestamente explicativos. En este artículo se presentan dos modelos psicológicos de crisis suicida: el modelo psicoanalítico y el existencial.
La Contribución de la Teoría del Apego a la Terapia Familiar Sistémica
Authors: Selvini Matteo , Sorrentino Anna Maria
Published: March 2019

Los autores muestran cómo la teoría del apego ha sido fundamental para ayudar a una parte del movimiento de la terapia familiar a liberarse de los límites de un purismo sistémico que no se interesa por la historia evolutiva de los pacientes y que se centra solo en los recursos, ignorando los límites del paciente y de sus familiares. Así pues, la teoría del apego es decisiva para construir hipótesis que no se queden atrapadas en el aquí y ahora. El terapeuta no es solo una base segura, sino que trabaja para activar una red de bases seguras: el trabajo en equipo crea la posibilidad de ser una referencia para padres y hermanos, favoreciendo el acercamiento y la reconciliación. Las cinco reorganizaciones del apego desorganizado son una guía útil para una valoración que integra los rasgos individuales de la personalidad con sus posibles matrices relacionales. Se centra no solo en el individuo estratégico sino también en el que sufre.
Apego y Trastornos Alimentarios: Implicaciones para la Intervención Psicoterapéutica
Authors: Hernangómez Criado Laura
Published: March 2019

En este artículo, se revisa la relación entre apego y trastornos alimentarios, profundizando en las variables mediadoras investigadas hasta el momento y en las implicaciones de estos resultados para la psicoterapia. Con énfasis en el papel de la relación terapéutica y la metacognición, especialmente en los casos más graves, se plantean propuestas para la adaptación de la terapia y el manejo de dificultades desde la consideración de las diferencias individuales y familiares en el apego.
Pannexin 2 Localizes at ER-Mitochondria Contact Sites
Authors: Le Vasseur Maxence , Chen Vincent C. , Huang Kate , Vogl Wayne A. , Naus Christian C.
Published: March 2019

Endomembrane specialization allows functional compartmentalization but imposes physical constraints to information flow within the cell. However, the evolution of an endomembrane system was associated with the emergence of contact sites facilitating communication between membrane-bound organelles. Contact sites between the endoplasmic reticulum (ER) and mitochondria are highly conserved in terms of their morphological features but show surprising molecular diversity within and across eukaryote species. ER-mitochondria contact sites are thought to regulate key processes in oncogenesis but their molecular composition remains poorly characterized in mammalian cells. In this study, we investigate the localization of pannexin 2 (Panx2), a membrane channel protein showing tumor-suppressing properties in cancer cells. Using a combination of subcellular fractionation, particle tracking in live-cell, and immunogold electron microscopy, we show that Panx2 localizes at ER-mitochondria contact sites in mammalian cells and sensitizes cells to apoptotic stimuli.
Source Country Economic Development and Dynamics of the Skill Composition of Emigration
Authors: Idu Roxana
Published: March 2019

This paper presents an endogenous growth model of migration and technological diffusion with transitional dynamics, which provide explanations for the empirical pattern of the mobility transition. A two-skill group extension of this model offers new hypotheses regarding the skill composition of emigration during the mobility transition. Skill-biased technological change (SBTC), which first occurs in the destination, raises the relative return to high skill migration and thus the high-to-low skill emigration ratio. As SBTC eventually diffuses to the source economy, it also raises the relative return to high skill investment there, and causes a decline in the high-to-low skill emigration ratio. Empirical evidence using bilateral migration data from 31 destinations and 195 origins is shown to support this hypothesis, with the average income of origins, at which the peak high-to-low skill emigration ratio is reached, is estimated at $2000 in 2011 US dollars PPP (adjusted for purchasing power parity). Furthermore, research and development intensity as a measure of SBTC in destinations is shown to be empirically, positively linked to the bilateral high-to-low skill emigration ratio.
Propagule Dispersal Determines Mangrove Zonation at Intertidal and Estuarine Scales
Authors: Wang Wenqing , Li Xiaofei , Wang Mao
Published: March 2019

Propagule dispersal has generally been recognized as a vital factor affecting the spatial structure of tropical forest plants. However, available research shows that this hypothesis does not apply to mangrove species the propagules of which are dispersed by water. Due to the lack of comprehensive and quantitative information as well as the high spatio-temporal heterogeneity of the mangrove environment, the exact factors affecting the spatial structure of mangrove forests are poorly understood. To assess this, we selected a mangrove estuary with high mangrove species richness that experiences great changes in water salinity. After investigating the zonation of mature mangrove individuals across tides and the estuary, we measured the size and initial specific gravity of the propagules and then selected the eight most common species from which to observe the changes in specific gravity, buoyancy, and root initiation during dispersal at different sites with different water salinity regimes. The relationships among distribution patterns, propagule establishment, and dispersal behavior were investigated. We found that mangrove propagule dispersal is not a passively buoyant process controlled by water currents. During dispersal, mangrove propagules can actively adjust their specific gravity and root initiation. The dynamic specific gravity of the propagules was negatively related to propagule buoyancy and surface elevation. The differences in propagule specific gravity corroborated the distribution patterns of the species across the intertidal zone and estuary. Mangrove zonation on both the intertidal and estuarine scale can be explained by the tidal sorting hypothesis, as zonation is controlled by the tidal sorting of the propagules according to buoyancy and by the differential ability of the propagules to establish in the intertidal zones. The results add new understanding of observed mangrove species zonation and should inform conservation managers when restoring mangroves or evaluating the potential impacts of global change and anthropogenic disturbances that might alter the hydrology, including the water salinity regime.
Consuming Blackberry as a Traditional Nutraceutical Resource from an Area with High Anthropogenic Impact
Authors: Vlad Ioana Andra , Goji Győző , Dinulică Florin , Bartha Szilard , Vasilescu Maria Magdalena , Mihăiescu Tania
Published: March 2019

The most serious quality issue of natural resources for human consumption or medicinal purposes is the contamination with pollutants harmful to consumers. Common blackberry (Rubus fruticosus L.) is a sought-after nutraceutical and an important component in herbal medicine in many places around the globe. The present study aims to analyze the level of heavy metal bioaccumulation in blackberry organs, as well as its spatial distribution in two consecutive years immediately after the interruption of the extended activity of the industrial source of pollution. The research was conducted in one of the most polluted areas in Romania and Eastern Europe, within a 26 km radius of the source of pollution. The Pb, Cd, Cu, and Zn concentrations in the leaves, flowers, and unwashed blackberry fruits were analyzed spectrophotometrically through flame atomic absorption spectroscopy (FAAS). The results show that blackberry is an important bioaccumulator of these heavy metals—71% of the Pb concentration values and 100% of the Cd concentration values exceeded the World Health Organization thresholds by up to 29 and 15 times, respectively. Also, the leaves are the largest reservoirs of Pb and Zn (the median values: 51.4 mg/kg dry weight and 105.2 mg/kg d.w., respectively), and the flowers contained the largest quantities of Cd and Cu (2.54 mg/kg d.w. and 11.3 mg/kg d.w., respectively). The Pb concentrations decreased by a power function in relation to the distance from the source of pollution. The implications of these results on the safety of the use of blackberry are discussed. The urgent necessity for food education of the local population which consumes contaminated nutraceutical products is emphasized.
VNF Placement Optimization at the Edge and Cloud †
Authors: Leivadeas Aris , Kesidis George , Ibnkahla Mohamed , Lambadaris Ioannis
Published: March 2019

Network Function Virtualization (NFV) has revolutionized the way network services are offered to end users. Individual network functions are decoupled from expensive and dedicated middleboxes and are now provided as software-based virtualized entities called Virtualized Network Functions (VNFs). NFV is often complemented with the Cloud Computing paradigm to provide networking functions to enterprise customers and end-users remote from their premises. NFV along with Cloud Computing has also started to be seen in Internet of Things (IoT) platforms as a means to provide networking functions to the IoT traffic. The intermix of IoT, NFV, and Cloud technologies, however, is still in its infancy creating a rich and open future research area. To this end, in this paper, we propose a novel approach to facilitate the placement and deployment of service chained VNFs in a network cloud infrastructure that can be extended using the Mobile Edge Computing (MEC) infrastructure for accommodating mission critical and delay sensitive traffic. Our aim is to minimize the end-to-end communication delay while keeping the overall deployment cost to minimum. Results reveal that the proposed approach can significantly reduce the delay experienced, while satisfying the Service Providers’ goal of low deployment costs.
The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?
Authors: de Cárcer Guillermo
Published: March 2019

The master mitotic regulator, Polo-like kinase 1 (Plk1), is an essential gene for the correct execution of cell division. Plk1 has strong clinical relevance, as it is considered a bona fide cancer target, it is found overexpressed in a large collection of different cancer types and this tumoral overexpression often correlates with poor patient prognosis. All these data led the scientific community to historically consider Plk1 as an oncogene. Although there is a collection of scientific reports showing how Plk1 can contribute to tumor progression, recent data from different laboratories using mouse models, show that Plk1 can surprisingly play as a tumor suppressor. Therefore, the fact that Plk1 is an oncogene is now under debate. This review summarizes the proposed mechanisms by which Plk1 can play as an oncogene or as a tumor suppressor, and extrapolates this information to clinical features.
An Archaeometallurgical Investigation on Metal Samples from the Chiaravalle Cross
Authors: Di Martino Daniela , Perelli Cippo Enrico , Scherillo Antonella , Kasztovszky Zsolt , Harsányi Ildikó , Kovács Imre , Szőkefalvi-Nagy Zoltán , Cattaneo Roberta , Gorini Giuseppe
Published: March 2019

The production and manufacturing techniques of metals involve expertise, and the study of ancient artifacts relies on interdisciplinary skills. Metalworking processes used in the production of jewelry masterpieces can, for example, give indications on the provenance of an ancient object of an unknown origin and the techniques used. In this regard, metallic samples from the Chiaravalle Cross (a beautiful processional cross with a complex structure, dating to the 13th century) have been studied, combining bulk and point measurements. Neutron-based experiments (like Prompt Gamma Activation Analysis and neutron diffraction) provide the bulk of the elemental and mineralogical composition, while particle induced X-ray emission analyses evidenced important details on its manufacturing techniques.
Rare Diseases with Periodontal Manifestations
Authors: Hanisch Marcel , Hoffmann Thomas , Bohner Lauren , Hanisch Lale , Benz Korbinian , Kleinheinz Johannes , Jackowski Jochen
Published: March 2019

Background: The object of this paper was to provide an overview of rare diseases (RDs) with periodontal manifestations and allocate them to relevant categories. Methods: In ROMSE, a database for “Rare Diseases with Orofacial Involvement”, all 541 entities were analyzed with respect to manifestations of periodontal relevance. Inclusion criteria were periodontally relevant changes to the oral cavity, in accordance with the 2018 version of the Classification of Periodontal and Peri-Implant Diseases and Conditions. Rare diseases were recorded, using the methodology described, and subsequently compared with the Orphanet Classification of Rare Diseases. Results: A total of 76 RDs with periodontal involvement were recorded and allocated in accordance with the Classification of Periodontal and Peri-Implant Diseases and Conditions. Of the 541 RDs analyzed as having known orofacial manifestations, almost 14 percent indicated a periodontally compromised dentition. Conclusions: Around 14 percent of RDs with an orofacial involvement showed periodontally relevant manifestations, which present not only as a result of gingivitis and periodontitis, but also gingival hyperplasia in connection with an underlying disease. Thus, dentists play an important role in therapy and early diagnoses of underlying diseases based on periodontally relevant manifestations.
A Multisensory Multilevel Health Education Model for Diverse Communities
Authors: Williams Olajide , Swierad Ewelina M.
Published: March 2019

Owing to their enormous capacity to improve health and save lives, public health researchers and practitioners have worked on developing effective frameworks for the optimization of health promotion strategies. A multilevel focus, as exemplified by the Socio-Ecological Model (SEM), is one common denominator among these frameworks. The SEM highlights important social and ecological influences on health behavior by delineating the different levels of influence. These include public policy, organizational, community, interpersonal, and intrapersonal levels, which, when considered during the development of health promotion campaigns—especially those that focus on health education—strengthen the influence of that campaign on targeted behaviors. However, the SEM lacks a complimenting framework for understanding the role of conventional and unconventional approaches to health education; that is, how to design a health education intervention that considers both the context, such as the social and ecological levels of influence, and the best approaches for developing and delivering the health education in a manner that optimizes its effectiveness in today’s modern and increasingly diverse world. Addressing this gap, the current article presents an integrative Multisensory Multilevel Health Education Model (MMHEM), which incorporates three key domains—(1) Art (innovativeness/creativity), (2) Culture (cultural tailoring), and (3) Science (evidence-based), while promoting the importance of considering the socio-ecological levels of influence on targeted behaviors. Using a successful health education intervention, called the Hip Hop Stroke, we deconstruct the Multisensory Multilevel Health Education Model and discuss its potential role as a guide for developing public health education interventions.
Sleep Quality among Police Officers: Implications and Insights from a Systematic Review and Meta-Analysis of the Literature
Authors: Garbarino Sergio , Guglielmi Ottavia , Puntoni Matteo , Bragazzi Nicola Luigi , Magnavita Nicola
Published: March 2019

Poor sleep is associated with bad health outcomes, worse wellbeing and decreases in performance, productivity and safety at work. Police officers are exposed to several risk factors including extended work schedules, shift work, occupational stress, dangerous and traumatic events and can, as such, develop sleep problems. The aim of the present study was to analyze the sleep quality among police officers. A systematic literature search, in PubMed/MEDLINE, PsycINFO, Scopus, ISI/Web of Science (WoS) and the Cochrane Library was conducted. Original articles, published in English, French, Italian, Spanish and Portuguese, the primary objective of which was the evaluation of the quality of sleep through the Pittsburgh Sleep Quality Index (PSQI) in Police Forces, were selected. From an initial sample of 1,149 studies, 13 articles were included in the meta-analysis (3,722 police officers). The pooled prevalence of bad sleep quality in police officers was 51% [95%CI 42–60%]. The pooled global score of the PSQI was 5.6 [95%CI 5.0–6.3], corresponding to a low average quality. At the meta-regressions, statistically significant associations could be found for work seniority (in terms of years of service) and being on shift. The poor quality of sleep in police officers could have negative consequences for workers’ health and for the safety of third parts. The implementation of health and sleep hygiene promotion programs in police forces is strongly recommended.
Use of Non-Linear Ultrasonic Techniques to Detect Cracks Due to Steel Corrosion in Reinforced Concrete Structures
Authors: Climent Miguel Ángel , Miró Marina , Carbajo Jesús , Poveda Pedro , de Vera Guillem , Ramis Jaime
Published: March 2019

In this work, non-linear ultrasonic wave techniques have been used to detect the onset of micro-cracking due to steel corrosion in model reinforced concrete elements. The specimens were of prismatic shape with a single steel rebar. The corrosion was forced by admixing an appropriate amount of sodium chloride at the moment of preparing the concrete mix, and by the application of an electric field, using a constant current density power source, and making the steel rebar work as the anode, and an external counter-electrode as the cathode. The preliminary results indicate that the onset of cracking seems to be accompanied by the appearance of higher-harmonic generation at the output signal (harmonic distortion), when the system is excited by the means of an ultrasound wave with a burst central frequency. Other phenomena related to the micro-cracks induced by corrosion, such is the parametric generation with respect to the fundamental amplitude, have not been observed until now.
Partial Discharge in Nanofluid Insulation Material with Conductive and Semiconductive Nanoparticles
Authors: Makmud Mohamad Zul Hilmey , Illias Hazlee Azil , Chee Ching Yern , Dabbak Sameh Ziad Ahmad
Published: March 2019

This study provides a thorough investigation of partial discharge (PD) activities in nanofluid insulation material consisting of different types of nanoparticles, which are conductive and semiconductive when subjected to high voltage stress is presented. Nanofluids have become a topic of interest because they can be an alternative to liquid insulation in electrical apparatus due to their promising dielectric strength and cooling ability. However, during in-service operation, PDs can occur between conductors in the insulation system. Therefore, this study presents the behavior of PDs within nanofluid dielectric materials consisting of conductive and semiconductive nanoparticles. The results show that there is an improvement in the PD resistance and a reduction in the tan delta of nanofluids at power frequency after the incorporation of conductive or semiconductive nanoparticles in the nanofluid oil. However, the most suitable concentration of conductive and semiconductive nanoparticles in the base fluid was found to be, respectively, 0.01 g/L and 1.0 g/L at PD inception and PD steady-state conditions. The clustering of nanoparticles in a nanofluid suspension due to PD activities is also discussed in this study.
Fire Performance of Heavyweight Self-Compacting Concrete and Heavyweight High Strength Concrete
Authors: Aslani Farhad , Hamidi Fatemeh , Ma Qilong
Published: March 2019

In this study, the fresh and hardened state properties of heavyweight self-compacting concrete (HWSCC) and heavyweight high strength concrete (HWHSC) containing heavyweight magnetite aggregate with 50, 75, and 100% replacement ratio, and their performance at elevated temperatures were explored experimentally. For fresh-state properties, the flowability and passing ability of HWSCCs were assessed by using slump flow, T500 mm, and J-ring tests. Hardened-state properties including hardened density, compressive strength, and modulus of elasticity were evaluated after 28 days of mixing. High-temperature tests were also performed to study the mass loss, spalling of HWSCC and HWHSC, and residual mechanical properties at 100, 300, 600 and 900 °C with a heating rate of 5 °C/min. Ultimately, by using the experimental data, rational numerical models were established to predict the compressive strength and modulus of elasticity of HWSCC at elevated temperatures. The results of the flowability and passing ability revealed that the addition of magnetite aggregate would not deteriorate the workability of HWSCCs and they retained their self-compacting characteristics. Based on the hardened densities, only self-compacting concrete (SCC) with 100% magnetite content, and high strength concrete (HSC) with 75 and 100% magnetite aggregate can be considered as HWC. For both the compressive strength and elastic modulus, decreasing trends were observed by introducing magnetite aggregate to SCC and HSC at an ambient temperature. Mass loss and spalling evaluations showed severe crack propagation for SCC without magnetite aggregate while SCCs containing magnetite aggregate preserved up to 900 °C. Nevertheless, the mass loss of SCCs containing 75 and 100% magnetite content were higher than that of SCC without magnetite. Due to the pressure build-up, HSCs with and without magnetite showed explosive spalling at high temperatures. The residual mechanical properties analysis indicated that the highest retention of the compressive strength and modulus of elasticity after exposure to elevated temperatures belonged to HWSCC with 100% magnetite content.
Study on the Stabilization of a New Type of Waste Solidifying Agent for Soft Soil
Authors: Shen Jiansheng , Xu Yidong , Chen Jian , Wang Yao
Published: March 2019

The use of desulfurization gypsum and steel/furnace slag composite cementitious material (DGSC) to solidify soft soil can fully utilize industrial wastes, reduce cement use and protect natural resources. By studying the unconfined compressive strengths of DGSC-solidified soil with different mix ratios, water-binder ratios and curing periods, the influence of those factors on the unconfined compressive strength of the soil can be analyzed. Furthermore, the quasi-water-cement ratio is introduced to predict the strength of the DGSC-solidified soil. The results show that the higher the DGSC content is, the better its effect on the soft soil. The variation in the unconfined compressive strength of DGSC-solidified soil overtime can be described by the same trend as that of cement-solidified soil but its early strength is lower than that of cement-solidified soil. When the water-binder ratio of the DGSC-solidified soil is the same as that of the cement-solidified soil, after a28-day curing period, the content of DGSC is higher than that of the 5% cement content, so the DGSC solidification effect is comparable to that of cement. Therefore, using DGSC instead of cement as a soft soil solidifying agent can meet the strength requirements of solidified soil.
Microstructural Modeling and Strengthening Mechanism of TiB/Ti-6Al-4V Discontinuously-Reinforced Titanium Matrix Composite
Authors: Zhao Shuai , Xu Yangjian , Pan Changliang , Liang Lihua , Wang Xiaogui
Published: March 2019

A novel modeling method was proposed to provide an improved representation of the actual microstructure of TiB/Ti-6Al-4V discontinuously-reinforced titanium matrix composite (DRTMC). Based on the Thiessen polygon structure, the representative volume element (RVE) containing the complex microstructures of the DRTMC was first generated. Thereafter, by using multiple user-defined subroutines in the commercial finite element software ABAQUS, the application of asymmetric mesh periodic boundary conditions on the RVE was realized, and the equivalent elastic modulus of the DRTMC was determined according to the homogenization method. Through error analyses on the experimental and calculated results regarding the equivalent elastic parameters of the DRTMC, the rationality of generating the DRTMC finite element model by using the present method was validated. Finally, simulations based on four types of network-like models revealed that the present simplifications to the particle shape of the reinforcement phase had less of an influence on the overall composite strength. Moreover, the present study demonstrates that the DRTMC enhancement is mainly attributed to the matrix strengthening, rather than the load-transferring mechanism. The strengthening influences of the distribution forms of the reinforcement phases, including their distribution density and orientation, were studied further. It was found that both the higher distribution density and limited distribution orientation of the particles would increase the probability of overlapping and merging between particles, and; therefore, higher strength could be yielded when the volume fraction of the reinforcement phase reached a certain threshold. Owing to the versatility of the developed methods and programs, this work can provide a useful reference for the characterization of the mechanical properties of other composites types.
Editorial for Special Issue “Structural Control of Mineral Deposits: Theory and Reality”
Authors: Chauvet Alain
Published: March 2019

“Structural Control” remains a crucial point that is frequently absent in scientific and/or economic analyses of ore deposits, whatever their type and class, although a selection of references illustrates its importance [...]
Effects of a Lysine-Involved Maillard Reaction on the Structure and In Vitro Activities of Polysaccharides from Longan Pulp
Authors: Yi Yang , Han Miao-Miao , Huang Fei , Wang Li-Mei , Min Ting , Wang Hong-Xun
Published: March 2019

The effects of amino acid-involved Maillard reactions (MRs) on the structure and activities of longan pulp polysaccharides (LPs), which were heteropolysaccharides mainly composed of glucose, galactose, mannose, rhamnose, glucuronic acid, ribose, and galacturonic acid, were investigated. The changes of browning degree and molecular weight (Mw) distribution in the MR systems containing LPs and amino acids (lysine, proline, or glycine) indicated that lysine was more active in conjugating with LPs. The MR-modified LPs (MLPs) obtained via a 4 h MR between LPs and lysine showed obvious structural differences from LPs. Specifically, particle-like LPs contained 94% fractions with a Mw less than 7.07 kDa, by contrast, network-like MLPs contained 45% fractions with a Mw larger than 264.1 kDa. Moreover, MLPs showed stronger radical scavenging abilities and macrophage immunostimulating effects, but weaker cancer cell growth-inhibitory abilities. The results indicate that the amino acid-involved MR is a promising method to modify native polysaccharides for better biological properties.
Differentiation of Fresh and Processed Fruit Juices Using Volatile Composition
Authors: Perestrelo Rosa , Silva Catarina , Silva Pedro , Medina Sonia , Câmara José S.
Published: March 2019

In the current study, a comprehensive approach based on headspace solid-phase microextraction (HS-SPME), combined with gas chromatography-quadrupole mass spectrometry (GC-qMS), was used to establish the volatile signature of fresh and processed fruit juices, obtained from the same batch of grapes, red fruits, orange, pear, and apple. This is a powerful tool for evaluating the impact of the production process on the volatomic pattern of fruit juice. A total of 169 volatile organic compounds (VOCs) belonging to different chemical groups were identified. Esters, carbonyl compounds, terpenoids, and alcohols are the major chemical groups in the investigated fruit juices. However, their contribution to the total volatile profile varied. Special attention should be paid to processed fruit juices to avoid the possible deleterious effects associated with the formation of furanic compounds (e.g., heat treatment), since their furanic content was significantly higher in comparison to that of fresh fruit juices. The knowledge obtained in the current study will allow for the introduction of modifications to the process involved in processing juice, which will improve the organoleptic characteristics of processed juices, contributing to a better acceptance by consumers. Furthermore, more assays should be performed to assess the effect of harvests, geography, and agronomy on the volatile profile of juices.
Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives
Authors: Ren Hang , An Haoyun , Tao Jingchao
Published: March 2019

Glycosylation of 6-amino-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine and its iodo- and bromo- analogues with the protected ribofuranose and 2′-deoxyribofuranose under different conditions resulted in the synthesis of N9- and N8-glycosylated purine nucleosides. Five key intermediate nucleosides, having 6-methoxy, 7-iodo, and 2-bromo groups, were further derivatized to 23 final 8-aza-7-deazapurine nucleoside derivatives. The structures of N9- and N8-glycosylated products were assigned based on UV and NMR spectra. HMBC analysis of 2D NMR spectra and X-ray crystallographic studies of the representative compounds unambiguously verified the connection of ribose ring to N9- or N8-position of the purine ring. The anticancer activity of these new compounds was evaluated.
Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA
Authors: Yang Yuan-Shuai , Wei Wei , Hu Xin-Xin , Tang Sheng , Pang Jing , You Xue-Fu , Fan Tian-Yun , Wang Yan-Xiang , Song Dan-Qing
Published: March 2019

Twenty-five new derivatives of 8-hydroxycycloberberine (1) were synthesized and evaluated for their activities against Gram-positive bacteria, taking 1 as the lead. Part of them displayed satisfactory antibacterial activities against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), as well as vancomycin-intermediate Staphylococcus aureus (VISA). Especially, compound 15a displayed an excellent anti-MRSA activity with MICs (minimum inhibitory concentrations) of 0.25–0.5 μg/mL, better than that of 1. It also displayed high stability in liver microsomes and whole blood, and the LD50 value of over 65.6 mg·kg−1 in mice via intravenous route, suggesting a good druglike feature. The mode of action showed that 15a could effectively suppress topo IV-mediated decatenation activity at the concentration of 7.5 μg/mL, through binding a different active pocket of bacterial topo IV from quinolones. Taken together, the derivatives of 1 constituted a promising kind of anti-MRSA agents with a unique chemical scaffold and a specific biological mechanism, and compound 15a has been chosen for the next investigation.
Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates
Authors: Wang Yixuan , Wang Huiqiang , Jiang Xinbei , Jiang Zhi , Guo Tingting , Ji Xingyue , Li Yanping , Li Yuhuan , Li Zhuorong
Published: March 2019

Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease. Using the fragment-hopping strategy, a series of 2-aryl-isoindolin-1-one compounds were designed, synthesized and investigated for their in vitro antiviral activity towards multiple EV-A71 clinical isolates (H, BrCr, Shenzhen98, Jiangsu52) in Vero cell culture in this study. The structure–activity relationship (SAR) studies identified 2-phenyl-isoindolin-1-ones as a new potent chemotype with potent antiviral activity against EV-A71. Ten out of the 24 tested compounds showed significant antiviral activity (EC50 < 10 µM) towards four EV-A71 strains. Compounds A3 and A4 exhibited broad and potent antiviral activity with the 50% effective concentration (EC50) values in the range of 1.23–1.76 μM. Moreover, the selectivity indices of A3 and A4 were significantly higher than those of the reference compound, pirodavir. The western blotting experiment indicated that the viral VP1 was significantly decreased at both the protein and RNA level in a dose-dependent manner following treatment with compound A3. Moreover, compound A3 inhibited the viral replication by acting on the virus entry stage. In summary, this study led to the discovery of 2-aryl-isoindolin-1-ones as a promising scaffold with potent anti-EV-A71 activities, which deserves further in-depth studies.
Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults
Authors: McHill Andrew , Czeisler Charles , Phillips Andrew , Keating Leigh , Barger Laura , Garaulet Marta , Scheer Frank , Klerman Elizabeth
Published: March 2019

The timing of caloric intake is a risk factor for excess weight and disease. Growing evidence suggests, however, that the impact of caloric consumption on metabolic health depends on its circadian phase, not clock hour. The objective of the current study was to identify how individuals consume calories and macronutrients relative to circadian phase in real-world settings. Young adults (n = 106; aged 19 ± 1 years; 45 females) photographically recorded the timing and content of all calories for seven consecutive days using a smartphone application during a 30-day study. Circadian phase was determined from in-laboratory assessment of dim-light melatonin onset (DLMO). Meals were assigned a circadian phase relative to each participant’s DLMO (0°, ~23:17 h) and binned into 60° bins. Lean (n = 68; 15 females) and non-lean (n = 38, 30 females) body composition was determined via bioelectrical impedance. The DLMO time range was ~10 h, allowing separation of clock time and circadian phase. Eating occurred at all circadian phases, with significant circadian rhythmicity (p < 0.0001) and highest caloric intake at ~300° (~1900 h). The non-lean group ate 8% more of their daily calories at an evening circadian phase (300°) than the lean group (p = 0.007). Consumption of carbohydrates and proteins followed circadian patterns (p < 0.0001) and non-lean participants ate 13% more carbohydrates at 240° (~1500 h) than the lean group (p = 0.004). There were no significant differences when caloric intake was referenced to local clock time or sleep onset time (p > 0.05). Interventions targeting the circadian timing of calories and macronutrients for weight management should be tested.
Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats
Authors: Konopelski Piotr , Konop Marek , Gawrys-Kopczynska Marta , Podsadni Piotr , Szczepanska Agnieszka , Ufnal Marcin
Published: March 2019

Recent evidence suggests that tryptophan, an essential amino acid, may exert biological effects by means of tryptophan-derived gut bacteria products. We evaluated the potential contribution of tryptophan-derived bacterial metabolites to body weight gain. The study comprised three experimental series performed on separate groups of male, Sprague-Dawley rats: (i) rats on standard laboratory diet treated with water solution of neomycin, an antibiotic, or tap water (controls-1); (ii) rats on standard diet (controls-2) or tryptophan-high (TH) or tryptophan-free (TF) diet; and (iii) rats treated with indole-3-propionic acid (I3P), a bacterial metabolite of tryptophan, or a vehicle (controls-3). (i) Rats treated with neomycin showed a significantly higher weight gain but lower stool and blood concentration of I3P than controls-1. (ii) The TH group showed significantly smaller increases in body weight but higher stool and plasma concentration of I3P than controls-2. In contrast, the TF group showed a decrease in body weight, decreased total serum protein and a significant increase in urine output. (iii) Rats treated with I3P showed significantly smaller weight gain than controls-3. Our study suggests that I3P, a gut bacteria metabolite of tryptophan, contributes to changes in body weight gain produced by antibiotics and tryptophan-rich diet.
Growth Patterns of Neonates Treated with Thermal Control in Neutral Environment and Nutrition Regulation to Meet Basal Metabolism
Authors: Kubota Shiro , Zaitsu Masayoshi , Yoshihara Tatsuya
Published: March 2019

Little is known about the growth patterns of low birth weight neonates (<2500 g) during standardized thermal control and nutrition regulation to meet basal metabolism requirements compared to those of non-low birth weight neonates (2500 g and above). We retrospectively identified 10,544 non-low birth weight and 681 low birth weight neonates placed in thermo-controlled incubators for up to 24 h after birth. All neonates were fed a 5% glucose solution 1 h after birth and breastfed every 3 h (with supplementary formula milk if applicable) to meet basal metabolism requirements. Maximum body-weight loss (%), percentage body-weight loss from birth to peak weight loss (%/day), and percentage body-weight gain from peak weight loss to day 4 (%/day) were assessed by multivariable linear regression. Overall, the growth curves showed a uniform J-shape across all birth weight categories, with a low mean maximum body-weight loss (1.9%) and incidence of neonatal jaundice (0.3%). The body-weight loss patterns did not differ between the two groups. However, low birth weight neonates showed significantly faster growth patterns for percentage body-weight gain: β = 0.52 (95% confidence interval, 0.46 to 0.58). Under thermal control and nutrition regulation, low birth weight neonates might not have disadvantages in clinical outcomes or growth patterns.
Enhancing the Mechanical and Thermal Properties of Epoxy Resin via Blending with Thermoplastic Polysulfone
Authors: Sun Zeyu , Xu Lei , Chen Zhengguo , Wang Yuhao , Tusiime Rogers , Cheng Chao , Zhou Shuai , Liu Yong , Yu Muhuo , Zhang Hui
Published: March 2019

Efficient enhancement of the toughness of epoxy resins has been a bottleneck for expanding their suitability for advanced applications. Here, polysulfone (PSF) was adopted to toughen and modify the epoxy. The influences of PSF on the mechanical and thermal properties of the epoxy resin were systematically studied by optical microscopy, Fourier transform infrared spectrometer (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analyzer (TG), dynamic mechanical thermal analyzer (DMA), mechanical tests and scanning electron microscope (SEM). The dissolution experimental results showed that PSF presents a good compatibility with the epoxy resin and could be well dissolved under controlled conditions. The introduction of PSF was found to promote the curing reaction of the epoxy resin without participating in the curing reaction and changing the curing mechanism as revealed by the FT-IR and DSC studies. The mechanical properties of PSF/epoxy resin blends showed that the fracture toughness and impact strength were significantly improved, which could be attributed to the bicontinuous phase structure of PSF/epoxy blends. Representative phase structures resulted from the reaction induced phase separation process were clearly observed in the PSF/epoxy blends during the curing process of epoxy resin, which presented dispersed particles, bicontinuous and phase inverted structures with the increase of the PSF content. Our work further confirmed that the thermal stability of the PSF/epoxy blends was slightly increased compared to that of the pure epoxy resin, mainly due to the good heat resistance of the PSF component.
A New Muslim Community: Children of Islam and Scotland †,‡
Authors: Bonino Stefano
Published: March 2019

The experience of being a Muslim in Scotland today is shaped by the global and national post-9/11 shift in public attitudes towards Muslims, and is infused by the particular social, cultural, and political Scottish ways of dealing with minorities, diversity, and integration. The paper explores the development of Muslim communities in Scotland, highlighting the ongoing changes in their structure and the move towards a Scottish experience of being Muslim. This experience combines a sense of civic and social belonging to Scotland with a religious and ideological commitment to Islam.
Influence of Digitalization on the Tasks of Employees with Disabilities in Germany (1979–2006)
Authors: Weller Sabrina Inez
Published: March 2019

The deployment of technology in the workplace is increasingly replacing routine tasks and creating more non-routine tasks. In this article, we investigate the influence of computer technology on tasks carried out by employees with disabilities compared to employees without disabilities. We assume significant differences between both groups and stronger substitutive and complementary effects of computer technology in the case of a higher degree of disability. We use four waves of the German BIBB-IAB (BIBB: Federal Institute for Vocational Education and Training- IAB: Institute of Employment Research) and BIBB-BauA (BIBB: Federal Institute for Vocational Education and Training- BauA: German Federal Institute for Occupational Safety and Health Employment surveys (1976–2006) to investigate the development of tasks and the influence of computer technology carried out by employees with disabilities compared to employees without disabilities. The results show a development of tasks carried out by employees with disabilities that is very similar to that of employees without disabilities. In line with the assumptions of the task-based approach, we find that computer technology in the workplace has a complementary effect on routine tasks and a substitutive effect on non-routine tasks carried out by employees with disabilities. Against our theoretical assumptions, we find no systematic differences in the effects of computer technology on the tasks of employees with and without a disability. Moreover, we do not find systematic differences with regard to the degree of disability.
Consumers’ Willingness to Pay for Foods with Traceability Information: Ex-Ante Quality Assurance or Ex-Post Traceability?
Authors: Hou Bo , Wu Linhai , Chen Xiujuan , Zhu Dian , Ying Ruiyao , Tsai Fu-Sheng
Published: March 2019

In this study, traceability in pork profile information with ex-ante quality assurance and ex-post traceability are constructed. Consumers’ willingness to pay (WTP) for traceability information is investigated in Wuxi, China, by combining the Multiple Price Lists method and the Becker–DeGroot–Marschak (BDM) experimental auction. The main factors affecting consumers’ WTP are also analyzed using a Tobit model. The results demonstrate that consumers have higher WTP for ex-ante quality assurance than for ex-post traceability. The highest WTP is for the ex-ante quality assurance attribute of pork quality inspection. Consumers’ WTP for traceability information is influenced by their individual characteristics, including age, education and income, as well as their concern and satisfaction about food safety and confidence in food safety labeling. The contribution of this paper is that it improves the meaning of traceable food information attributes and measures the significance of attributes to consumers. Furthermore, this paper introduces a Becker–DeGroot–Marschak experimental auction method which amends the measurement deviation of hypothetical experiments.
Assessing the Performance of the WOFOST Model in Simulating Jujube Fruit Tree Growth under Different Irrigation Regimes
Authors: Bai Tiecheng , Zhang Nannan , Chen Youqi , Mercatoris Benoit
Published: March 2019

Cropping system models are widely employed to evaluate plant water requirements and growth situations. However, these models rarely focus on growth studies of perennial fruit trees. The aim of this study was to evaluate the performance of the WOFOST (WOrld FOod STudies) model in simulating jujube fruit tree growth under different irrigation treatments. The model was calibrated on data obtained from full irrigation treatments in 2016 and 2017. The model was validated on four deficit percentages (60%, 70%, 80%, and 90%) and one full irrigation treatment from 2016 to 2018. Calibrated R2 and RMSE values of simulated versus measured soil moisture content, excluding samples on the day of irrigation and first day after irrigation, reached 0.94 and 0.005 cm3 cm−3. The model reproduced growth dynamics of the total biomass and leaf area index, with a validated R2 = 0.967 and RMSE = 0.915 t ha−1, and R2 = 0.962 and RMSE = 0.160 m2 m−2, respectively. The model also showed good global performance, with R2 = 0.86 and RMSE = 0.51 t ha−1, as well as good local agreement (R2   ≥   0.8 ) and prediction accuracy (RMSE ≤   0.62 t ha−1) for each growth season. Furthermore, 90% of full irrigation can be recommended to achieve a balance between jujube yields and water savings (average decline ratio of yield ≤ 3.8%).