bluuebunny/crossref_metadata_2025 huggingface dataset:
A 20th-century discovery: the influence of environmental factors and space structure arrangement on teaching
Authors: Wang Yilin
Published: August 2022

The tradition of classroom space design is formed because people need to find a formal occasion for the dissemination of ideas and knowledge. Whether it is the earliest school in China or the earliest mode of communication in the square in the West all emphasize Teaching, the one who teaches is the leading, the dominant, and the one who learns is the passive receiver. It was not until the last century that people began to notice the significance of "Teaching and Learning" and made changes in the structure of the classroom. This article compares the traditions of Classroom space design and its functions. By doing that, it is argued that the 20th-century design of Classroom re-invent the function of teaching and learning interactions.
Evaluation and Suggestions of commercial spaces for Covid-19 prevention in Edinburgh, UK
Authors: Zhang Yifan
Published: August 2022

The global outbreak of COVID-19 poses a severe threat to various frontiers of life, which has attracted the wide attention of the government and the people to the epidemic disease. Various industries, therefore, have formulated epidemic prevention measures. The city’s public spaces are the main areas of close contact with people, which is the difficulty and critical point of epidemic prevention, especially in ancient cities with dense buildings. This article takes the city of Edinburgh in the UK as an example to explore the current situation and spatial problems of public space in residential areas along the street in the post-epidemic era by questionnaire survey. Meanwhile, this study also discusses and proposes measures to optimize the spatial contradictions of commercial spaces on the ground floor affected by the epidemic. Results show that commercial spaces on the ground floor are urban spaces with a highly dense crowd, high-risk disease diffusion, and relatively inferior control capability during the epidemic. Many ancient buildings in Edinburgh that have been preserved for hundreds of years also have some drawbacks such as narrow interior space and poor ventilation conditions, exacerbating the spread of the epidemic. By contrast, green space is more conducive to epidemic prevention and control. Combined with the advantages of green space, it is suggested to introduce green plants and improve ventilation of commercial spaces to reduce the spread of the epidemic, such as green plants separating spaces and ventilation filtering air.
The Relationship between Car Caster Angle and the Directional Stability of Car
Authors: He Hao
Published: August 2022

Appropriate alignment parameters may maintain stability of driving and handiness of operation, and automatic returnability of the steering system when the vehicle goes on straight. The alignment parameters of wheel and the steering mechanism are very important factors on tire wear. Among these parameters, the caster angle of the car is one of the most important factors to maintain the stability of the car. Choosing a suitable caster angle will reduce the wear degree of the car and improve the safety factor. Decades of research into the relationship between vehicle stability and caster angle have been exhaustive. From a large number of experiments in the past to the development of modeling software in recent years, people can use modeling software to simulate and obtain more accurate results. It will focus on the analysis methods using several typical modeling software on the market, and finally obtain the quantitative and qualitative relationship between the vehicle directional stability and caster angle.
The recent progress of nanofluids and the state-of-art thermal devices
Authors: Zhang Yichi , Zhou Yan
Published: August 2022

Nanofluids have been continuously investigated as innovative fluids in the last decades. The unique thermophysical properties exhibited by nanofluids have led to a variety of applications in modern energy-scarce environments. The purpose of this paper is to provide an overview of recent advances in nanofluids in cooling as well as to summarize the controversies of the existing applications. The development of electronic devices has heightened the need for an effective cooling system. Nanofluids in solar collector applications have greatly improved the thermal efficiency and solar energy utilization compared to conventional fluids, which can greatly alleviate today's energy problems. The cost of nanofluids in commercial applications may be too high, and long-term stability cannot be guaranteed due to the impacts of the thermal efficiency of nanofluids. More innovative approaches are needed to improve the cost and stability of nanofluids to cater to the commercial market. These results aim to provide a deeper understanding of the thermophysical properties and applications of nanofluids and to understand the limitations and potential for future improvements.
The State-Of-Art Aerodynamic Designs On The Open Wheel Race Cars
Authors: Wong David
Published: August 2022

The F1 race car industry is forever innovating and overcoming difficulties as there are so many variables and uncertainties on an object moving at over 360kpm. This paper will discuss the different designs’ effectiveness and variables that affect the performance of such designs. Computational Fluid Dynamics (CFD) simulations will be examined, along with physical tests to achieve the best results, and to form an accurate conclusion. The paper concluded the relationship between proximity to ground, wing incidence with downforce, including the cause of force reduction phenomenon. Individual study and interactions of front wing and wheel is also discussed with several CFD figures. Overall, these results shed light on guiding further exploration of aerodynamic design for open wheel race cars.
The Progress and Application of Aerodynamics of the TOL Modes of Flying Vehicle
Authors: Shi Zhengyang
Published: August 2022

In general, flying vehicle represents for hybrid vehicle possesses fixed wing and the ability to fly based on aerodynamics principles. This paper will discuss the aerodynamic technology from the perspective of the application of flying vehicles. Specifically, the aerodynamic concepts such as lift, and wing design will be discussed. Moreover, the current state-of-art of the flying vehicle will be discussed. In addition, the state-of-art specific products will be introduced to help explain the current state-of-art. According to the analysis, the flying vehicle has great prospects. In the future, it is possible to eliminate traffic congestion and relieve pressure on the present metropolitan transportation network by applying this technology. Overall, these results shed light on the guiding the further exploration of flying vehicle in terms of aerodynamics.
Nanoparticles in sunscreen: exploration of the effect and harm of titanium oxide and zinc oxide
Authors: Lyu Wenrui , Qian Mile , Yang Fan
Published: August 2022

In recent years, cosmetics have shown a positive development due to its own various properties, functionalities and applications. But as we know, microorganisms can cause the decomposition, deterioration and corruption of cosmetics, bringing economic losses. Therefore, commodities with bactericidal and antibacterial effects are attracting more and more people's attention. People found nanoparticles can be used in the cosmetics like sunscreen to have UV protectection and prevent bacteria simultaneously. In this review, it firstly discuss the nanotechnology and different mechanisms of process of sun protection. In main body, it focused on the nano size of titanium dioxide and zinc oxide particles in sunscreen. Then taking a deeply research on their preparation, effectiveness and toxicity, respectively. In nano titanium dioxide part, because of specific functions, the antibacterial property of it is also been shown. Finally, having a summary and expectation of the nano particles in sunscreen.
Emerging Vaccine Immunotherapy In NSCLC: The Adverse Reactions of Recent Clinical Trials and Future Directions
Authors: Yang Yuhao , Zeng Jingyi , Zhao Ruijia
Published: August 2022

Lung cancer is the most common primary malignant tumour of the lung today and can be classified into two types, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), depending on their histopathological characteristics. The incidence and mortality rates of lung cancer are currently extremely high and, on the rise, worldwide. However, normal scientific methods are not sufficient enough to cure lung cancer, but only to monitor the spread of cancer cells and inhibit them to a certain extent, so it is urgent to find effective treatments for lung cancer. This article focuses on the mechanisms of cancer vaccines for non-small cell lung cancer and a review of recent vaccine immunotherapy for lung cancer. This article also discusses some clinical adverse reactions, in order to provide a reference for vaccine immunotherapy in the future.
CAR-T Therapy: A Promising Cancer Treatment
Authors: Fang Yixuan , Liu Boxu , Song Wenze
Published: August 2022

CAR-T therapy is a new clinical treatment option. It is the focus of an increasing number of researches, all of which suggested that it has a beneficial therapeutic effect on a variety of diseases, especially blood cancer. In this paper, clinic applications of CAR-T therapy for many diseases are listed, including B-cell acute lymphoblastic leukemia, Hepatitis B, and Human Immunodeficiency Virus. The differences between CAR-T therapy and other cancer treatments like tumor-infiltrating lymphocyte and T cell receptor therapy were discussed, standard biological medicines, and antibody-mediated anti-cancer drugs. The study also looks at the limitations and side-effects of CAR-T therapy, such as toxicity, and missing the target. The disadvantages, constraints, and options for improvement were also discussed in the paper. To summarize, CAR-T therapy has a good therapeutic function on some illnesses, although it is still in the experimental stage and is not commonly used in the clinic. In the near future, CAR-T therapy is likely to be used in a rising range of therapeutic therapies. In general, this paper can help get a better knowledge of CAR-T treatment, as well as a more exact comprehension of its future evolution.
Effectiveness of Cytokine-Related Combination Immunotherapy with Conventional Oncological Treatment
Authors: Fan Zimeng , Li Zhian , Sun Liwen
Published: August 2022

This review will provide an overview of cytokine and cytokine-based immunotherapy and focus on recent developments in new-era oncological treatment, including several combinations of both conventional cancer therapy and novel immunotherapy with cytokine, and their applications in clinical research. There are five main parts, (1) The technology of cytokine immunotherapy, (2) The function of cytokine immunotherapy and defects of cytokine as a monotherapy, (3) The specific cancers that are targeted by synergistic cytokine immunotherapy, and (4) Prospects of cytokine in immunotherapy.
Genetic Mutations That Lead to Ohtahara Syndrome and Childhood Absence Epilepsy
Authors: Liu Jiakang , Shao Tianxing
Published: August 2022

Since epilepsy has become one of the biggest problems worried by the world, especially affecting thousands of children every year, many scholars have developed some therapies to try to save those families. One of the reasons why some people suffer from such illness is the genetic factors, which changes the function of the corresponding protein and causes a seizure. Among them, two representative diseases are Ohtahara syndrome and Childhood Absence Epilepsy. In the last century, as the mutated genes and the mechanisms of these two syndromes were still largely unknown, general antiepileptic drugs for them weren’t performing well in some conditions. Therefore, the demands for the mechanisms for these two diseases were increasingly higher though the complexity of human genes and genetic mutation still remains a challenging problem to the current technology. Luckily, extensive preclinical studies have shown that new drugs have promising therapeutic effects on these two syndromes. This article introduces the therapies for Ohtahara syndrome and Childhood Absence Epilepsy. There are going to collect the factors resulting from Childhood Absence Epilepsy and Ohtahara syndrome. Concluding past treatments and comparing them with the new therapies to find the medical progress in these two illnesses and whether Allopregnanolone, antisense oligonucleotides (ASOs) can help to treat Ohtahara syndrome, Zonisamide (ZSN), Levetiracetam (LEV), Topiramate (TPM) can treat Therapy-Resistant CAE.
An Application of Generalized Linear Models to Fine Needle Aspiration in Breast Cancer
Authors: Zeng Chudi
Published: August 2022

Breast cancer is currently the most dangerous cancer for women worldwide. Doctors routinely employ biopsies, diagnostic mammograms, and other techniques to detect and diagnose breast cancer. The Fine Needle Aspiration, also referred to as fine needle biopsy, is a technique for assessing tumors that involves inserting a needle into a mass to retrieve alive cells. However, the current breast biopsy test is time-consuming and unable to detect early breast cancer. Applying the statistical tools to fine-needle aspiration is helpful in developing its feasibility and reducing test time, thereby reducing the cost of service as well as waiting time. In this study, the diagnostic model was fitted with a generalized linear model as the framework and Least Absolute Shrinkage and Selection Operator regression as the essential methods. Amongst cellular level features, which are variables in the model, some features were identified that play an essential role in the models, including texture, smoothness, concave points, and fractal dimension. The high accuracy (>0.9) obtained from the model in data testing supported that Generalized-Linear-Models-based machine prediction can effectively assist physicians in their clinical diagnosis. In addition, essential features in the model could be considered to have some association with the hidden lesion of breast cancer.
Evaluation on Current Lung Cancer Situation in China
Authors: Xie Zijun
Published: August 2022

Lung cancer has been a serious problem all around the world. Especially in China, lung cancer has been listed as one of the top cancers which leads to a high prevalence rate and mortality. This paper aims to give a brief conclusion on various origins of lung cancer for different crowds in China. Moreover, the paper gave a conclusion on current treatment and new theories for both small cell lung cancer and non‐small cell lung cancer. At the end of this paper, constructive suggestions were put forward for reducing the prevalence rate of lung cancer and the death rate it causes.
Malaria in Sub-Saharan Africa: Current Situation and Future Strategies
Authors: Wang Yuxin
Published: August 2022

Malaria is a life-treating disease caused by parasites, which can be transmitted by mosquitoes. Some population groups, such as newborn babies, children under five, and people in pregnancy, are vulnerable to malaria and may likely develop severe diseases. Nearly half of the population around the world was at risk of developing malaria in 2020, even though many countries have successfully eliminated malaria already. Thus, there is an urgent need to eradicate malaria around the world. Although malaria incidence has decreased significantly due to the worldwide implementation of various interventions, sub-Saharan Africa (SSA) holds a significant portion of the cases and deaths. Thus, it is critical to reduce malaria incidence in SSA in order to reduce the global malaria burden. This article summarizes the policies implemented from past to present in SSA the challenges that the region currently encounters, and future strategies the region should develop based on the success of past practices of other countries.
Analysis of vascular robot optimization scheme based on dynamic planning and ARIMA model
Authors: Deng Bowen , Lu Jiayu , Cao Yue
Published: August 2022

The study of vascular robots has become a new research hotspot in the interdisciplinary field and is of pivotal importance to the field of minimally invasive therapy. In this paper, we focus on the development of the ordering scheme of vascular robot, establish the optimal ordering model of vascular robot based on the idea of dynamic programming, calculate the minimum operating cost of the ordering scheme through LINGO software programming, and provide a specific weekly ordering scheme for the hospital to order vascular robot. Firstly, the optimal ordering model of the vascular robot is established based on the idea of bottom-up solution of dynamic programming in order to solve the specific to weekly ordering scheme. Second, a mind map format is adopted to sort out the problem, which allows a clearer analysis of the topic conditions. Then, the correctness of the model solution is checked by using segmented programming verification, which enhances the persuasive power of the model. Finally, the principles of machine learning are combined to build.
Function, Injury, and Treatment for Meniscus
Authors: Cao Jinyuan , Chen Beijie
Published: August 2022

The meniscus is considered a vital structure for maintaining normal functions and perennial health of the knee joint. This study focuses on the meniscus and discusses its function, injuries and the corresponding treatments. Results show that two menisci are located in the knee joint- medial and lateral meniscus, which are different in shape but work together to provide specific functions. The main functions of the meniscus include load sharing, shock absorption, stability, joint lubrication and nutrition. Meniscal injuries include vertical longitudinal, radial, horizontal (cleavage), degenerative (complex), and bucket-handle tears, all of which can cause serious knee morbidity. There are different symptoms of meniscus damage, and the severity of the damage can be identified from the symptoms. Once the meniscus injury is found, conservative or surgical treatment should be carried out immediately. Conservative treatments generally include massage, acupuncture, and slight movement, as well as drug treatment. Surgical treatments include meniscus suture, partial meniscectomy, and meniscectomy. If it is not treated in time, the meniscus could cause irreversible damage and a series of sequelae.
The Gut Microbiota Dysbiosis as a Trigger of Inflammation-Driving Pathogensis of Alzheimer’s Disease
Authors: Chen Keyin , Wei Yuchen , Xing Tianhao
Published: August 2022

Alzheimer's disease (AD) is a degenerative disease of the central nervous system, and its pathogenesis is very complex. Gut microbiota is an immense and complicated microbial community that is regarded as the “second brain “by scientists. These microorganisms exist in the ecosystem of the gastrointestinal tract which is in the human body and form a relatively stable environment within the gastrointestinal tract. As a large number of microorganisms that can survive and coexist harmoniously in the human body, intestinal flora is a very important environmental factor and plays a very important role in the mutual transformation of people's health and diseases. On this basis, the cerebral intestinal axis is a two-way information regulation system that connects the brain and gastrointestinal functions. This means that intestinal microorganisms can participate in the brain-intestinal axis. Recent studies have shown that disturbances (compositional changes and translocations) of the gut microbiota are associated with neurological disorders (AD), where the gastrointestinal tract communicates with the central nervous system via the gut-brain axis, including direct effects on nerves, endocrine pathways, and immune regulation. Animal models, fecal microbiota transplantation, and probiotic interventions provide evidence for the association of gut microbiota with AD. The leaked bacterial metabolites may directly damage neuronal function, and may also induce neuroinflammation and promote the pathogenesis of AD. Therefore, the main goal of this review is to summarize, study and discuss the nowadays research and results of intestinal microbiota in Alzheimer-related mechanisms and to understand the relevance, function, and impact between the mechanism and Alzheimer’s disease.
Key Role of Deliberate Rumination in Posttraumatic Growth Among Sexually Traumatized Survivors
Authors: Liu TzuTing
Published: August 2022

This article discusses the relationship between posttraumatic growth and deliberate rumination and main cause of deliberate rumination. As Tedeschi & Calhoun (2004) mentions, the concept of posttraumatic growth (PTG), people who experiences a traumatic event not only show posttraumatic symptoms but can also have a positive change in mentality afterwards. According to the research of Hannah Stockton (2011), PTG is positively correlated with deliberate rumination. The model of PTG proposed by Tedeschi & Calhoun (2004) shows that after experiencing a traumatic event, the individual will encounter cognitive challenges, a change in goal of life and beliefs and enter the stage of intrusive rumination. In the stage of intrusive rumination, in the process of self-disclosure or after a period of time, the patient will give up past cognition, undergo a change in mood, and then enter the stage of refined rumination, which is shown to rebuild cognition, and altered priorities.
Effect of Ganoderma lucidum fermentation on the content and α-glucosidase inhibitory activity of mulberry leaves flavonoid
Authors: Hu Xinyu
Published: August 2022

Diabetes is now a worldwide disease that has a negative impact on human health.As a result,the search for low-cost,safe,and effective diabetes treatment drugs derived from natural medicinal plants has become a research priority.Mulberry leaf(ML)flavonoids have been proven to be a highly effective α-glucosidase inhibitor and have a good effect on the treatment of diabetes.The solid state fermentation of Ganoderma lucidum utilizing ML as substrate was explored in this study with the goal of increasing the concentration and-glucosidase inhibitory effect of mulberry leaf flavonoid(MLF).The results indicated that fermented by G.lucidum for 8 d could increase the content of MLF from 1.596 mg/ml to 4.736 mg/ml.Meanwhile the polysaccharide in ML would be degraded and utilized as nutritions to support the cell growth of G.lucidum.The inhibitory rate of MLF on α-glucosidase was significantly enhanced by fermentation.During the concentration of 10μg/ml,the α-glucosidase inhibition rate of MLF was enhanced from 45.31±2.24%to 73.46±3.28%when fermented by G.lucidum for 8d.Moreover,it was found that the inhibition type of MLF would change from competitive inhibition to mixed-type inhibition.This study will serve as a reference for microbial fermentation and enrichment of medicinal plant active components,as well as a contribution to the high-value-added use of mulberry leaf resources.
Advances in Research and Treatment on Patients with Alzheimer's disease Induced by Sleep disorders
Authors: Li Sijing
Published: August 2022

Alzheimer's disease (AD) is a disease characterized by memory impairment, loss of words and inability in emotional control that occurs in the early and intermediate stage of the end of our lives. A number of studies have shown that the incidence and severity of AD is higher in patients with sleep disorders than in healthy people. The pathogenic mechanism of AD is still inconclusive, while several hypotheses have been proposed according to its etiological characteristics: Some studies suggest that the β-amyloid protein hypothesis and the mechanism of abnormal phosphorylation of protein tau induced by sleep disorders may be the key factors leading to AD. This paper will summarize the mechanisms of AD induced by sleep disorders and discuss the current therapies approaches to it, which included pharmacological therapy, using Trazodone, Midazolam Maleate tablets, Gardenia Citrusaurantium capsules as well as non-pharmacological therapy, which use aerobic exercise and light therapy, promoting the idea of relieving sleep disorders as an adjunctive treatment for AD. The contents summarized in this paper have some significance of reference to the direction of treatment of AD sleep disorders.
Classification, Risk Factors, Diagnoses, and Examination for Six-Type Meniscus Tears
Authors: Zhang Maida
Published: August 2022

The knee is the connection of the tibia and femur, which are two bones near to knees, and the menisci are in the knee joint shaped in two wedge pieces of fibrocartilage. Meniscus tears are considered the most common knee injuries and happen from acute trauma - like the fibrocartilage of meniscus tears, breaks, cracks, ruptures, or splits - or as the result of degenerative changes that happen over time. This study discussed the classification, risk factors, diagnoses, and examination for meniscus tears. The result shows that there are six common meniscus tears including bucket handle, flap, radial, degenerative, horizontal, and longitudinal meniscus tears. Risk factors of meniscus tears include age, gender, limb alignment, accidents, sports injuries, and osteoarthritis. Physical examinations and imaging examinations are commonly used techniques. Magnetic Resonance Imaging (MRI) is considered the most typical standard of testing meniscus tears. It can identify different types of meniscus tears and detect any associated damage to the ligaments, cartilage, and tendons.
Research Status of HPV and Cervical Cancer
Authors: Li Jinghan , Liu Jinyang , Liu Xiaoxi , Wang Zehua
Published: August 2022

Cervical cancer is a worldwide malignant tumors in gynecology, which does great harm to women's health. The pathogenesis of cervical cancer is mainly related to the persistent infection of high-risk HPV virus. This paper mainly studies the relationship between HPV and cervical cancer, and finds that there is a close relationship between them. The significance of our study of this subject is that it is now clear that cervical cancer is transmitted through viruses and vectors, which is a great discovery. In this way, many years before the occurrence of cervical cancer, there is enough opportunity to find it and eliminate it, which is a very great contribution, so many patients who should have cervical cancer have been blocked, ensuring the health of women to a great extent.
A Review on the Diagnosis and Treatment of Syphilis
Authors: Chen Qianqi , Yang Yiyao
Published: August 2022

Syphilis is a multi-phase sexually transmitted disease through contacting with a partner infected by syphilis or from a gravida to her newborn congenitally. The reappearance of syphilis is a severe public health concern, particularly because syphilis lesions would boost the chance of acquiring and spreading human immunodeficiency virus (HIV) infection. A dose of benzathine penicillin G (BPG) through intramuscular injection is the current treatment for syphilis, which is the optimal treatment for all stages of syphilis. Although some alternatives such as doxycycline and ceftriaxone are also evidently effective, the optimal therapy is still BPG, especially in latent syphilis and pregnancy. Because of the clinically significant azithromycin resistance, this second-line medication is no longer used routinely. Currently, macrolide resistance is the only antibiotic resistance with clinical evidence. Even though still no vaccine is published for syphilis, syphilis is a promising disease for vaccine development. The vaccine for syphilis is currently under research. This paper contained information about the pathological process, symptoms, diagnosis of syphilis, and effective treatment using antibiotics. The review also discussed future vaccine directions.
Evolution of COVID-19 as well as its different variants
Authors: Sun Yutong
Published: August 2022

COVID-19, first appeared in 2019, it has fulfilled every corner of our life, causing a lot of inconvenience to our daily life. People around the world all have the will to decrease the rate of infection. Some countries have used herd immunity, some use lockdown, other countries use social distancing and so on, but they cannot fully control the spread of COVID-19. Surveillance, vaccine development and its coverage are insufficient for a therapeutic and preventative approach. Besides, variants of COVID-19 further aggravate the tension due to their uncertainty. This research is based on a review of the literature with the goal of comparing different variations and their severity. Despite the fact that practically all countries have demonstrated active resistance to COVID-19 by unwavering efforts such as epidemic research and vaccine development, there are still many aspects that need to be investigated and researched.
The Progress of Yoga for the Treatment of Anxiety
Authors: Dai Yi , Li Jie
Published: August 2022

Anxiety disorders include generalized anxiety disorder (GAD), panic disorder, phobia, social anxiety disorder (SAD), and separation anxiety disorder. So far, the etiology of anxiety disorder is complex. its pathogenesis is not clear. It’s the result of the comprehensive effect of genetic and psychological factors. The emotional control loop in the brain is composed of the prefrontal lobe, amygdala, hippocampus, hypothalamus, anterior cingulate us, etc. The abnormal structure, function or connection of these areas can cause emotional control disorders and constitute the pathological structural basis of anxiety disorders. The first-line therapies are selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. Traditional drug therapy or psychotherapy has certain side effects. As a safe and effective adjuvant therapy, yoga has attracted more and more attention. As a result, we researched the effects of yoga on brain bioelectrical activity, neurotransmitters, and synaptic plasticity in the literature. as well as articles about how yoga assists patients with a range of diseases. These findings were utilized to evaluate the role of yoga practice in anxiety disorder treatment.
Application of C-MET Inhibitors in the Treatment of Non-small Cell Lung Cancer
Authors: Zhou Muge
Published: August 2022

Non-small cell lung cancer (NSCLC) is a kind of refractory lung cancer. Under traditional cisplatin treatment, it is difficult for patients, especially the advanced cancer patients, to have a high cure rate and survival rate. Abnormal histological variants may lead to NSCLC. Mutations in C-MET may lead to abnormal downstream metabolism, which in turn triggers unrestricted cell growth and metastasis. Therefore, C-MET inhibitors can inhibitive the overexpression and activation of C-MET by blocking the gene pathway, in result in that the growth and the spread of cancer cell can be inhibitived. A variety of C-MET inhibitors such as crizotinib, cabonitinib, capmatinib, etc., have been found to have good therapeutic activity and considerable clinical data. This paper discussed the C-MET as a therapeutic target in NSCLC, and outline the applications in clinical and therapeutic effects of various C-MET inhibitors.
Advances in biosensor technology in clinical medicine
Authors: Wu Wenzheng , Meng Chengzhen , Zhao Xiaoyi , Yun Jingyi , Wang Shihao , Zhao Wei , Shan Pufan
Published: August 2022

With the rapid development of science and technology and medical technology, the development of biosensor technology is on the fast track and is becoming increasingly integrated into clinical care. This phenomenon has revolutionised the healthcare industry, but at the same time, the drawbacks are also becoming apparent. In this paper, we examine the process of integrating biosensor technology with clinical care, discussing the current state of integration and making recommendations accordingly.
Research progress of IgA nephropathy markers
Authors: Mou Yunying , Liang Kexin , Chang Hongyuan , Tian Jiao , Zheng Yongshun , Wang Shihao
Published: August 2022

IgA nephropathy is one of the most common forms of primary glomerulonephritis, and its clinical presentation and prognosis vary greatly among individuals, so early identification of individuals at high risk of poor prognosis is crucial. Currently, the clinical predictors of IgAN include hypertension, proteinuria, glomerular filtration rate and Oxford pathological staging, which are non-specific, invasive and delayed. With further research into the pathogenesis of IgAN, some new, simpler and earlier biomarkers have been identified. In this paper, the role of cytokine, protein and nucleic acid markers in the diagnosis of IgA nephropathy is described in a comprehensive manner based on the pathogenesis of IgA nephropathy. It is expected that based on the pathogenesis of IgA nephropathy, more markers of IgA nephropathy will be discovered by studying the four-fold strike doctrine and other related doctrines to help detect subclinical disease activity, monitor disease progression and assess treatment.
PENGARUH LATIHAN MEDITASI DENGAN TINGKAT KECEMASAN PERAWAT YANG BERTUGAS DI RUANG ISOLASI COVID-19 RUMKIT TK. II UDAYANA
Authors: Artaguna I Made , Sukmandari Ni Made Ari
Published: August 2022

Nurses as the front line in handling COVID-19 are at risk of experiencing anxiety disorders due to the increasing workload, worrying about their health, and that of their families. Meditation is an attempt to improve stress conditions and eliminate psychosocial problems. This study aims to determine the effect of meditation practice on the anxiety level of nurses on duty in the COVID-19 Isolation Room of Rumkit Tk. II Udayana. This study used a pre-experimental method with a One group pre-test-posttest design. This study involved 23 samples selected by purposive sampling technique. Collecting data using the Hamilton Anxiety Rating Scale, meditation is given for 15 minutes every day for a week. Data analysis consists of data analysis using paired t-test. The test results showed that the average pre-test anxiety was 23.96 and the post-test was 9.65. The results of the Paired t Test showed that the t value = 19.200 > 2.069 and the p value 0.001 < 0.05 indicating there was a significant difference in the level of anxiety of nurses before and after doing meditation. Isolation. It is recommended to hospitals to use meditation practice as a collaboration in order to reduce anxiety levels and it is necessary to increase promotion so that the management of anxiety levels using meditation exercises is increasingly known to the public.
EFEKTIVITAS TERAPI BEKAM KERING TERHADAP INTENSITAS NYERI LUTUT PADA PENDERITA OSTEOARTRITIS DI PRAKTIK PERAWAT MANDIRI LATU USADHA
Authors: Firsia Sastra Putri Desak Made
Published: August 2022

Background: Knee pain is an uncomfortable feeling, from mild, moderate, or severe which is very subjective and only people who experience it can explain and evaluate the feeling. Data obtained in May 2021 at the Latu Usadha Independent Nurse Practice as many as 21 visiting patients and 11 patients experiencing knee pain.

Objective: To describe the effectiveness of dry cupping therapy on the intensity of knee pain in Osteoarthritis sufferers at the Latu Usadha Independent Nurse Practice.

Methodology: Pre-Experimental Design with one group pretest-posttest design, research subjects are knee pain sufferers, non-probability sampling using purposive sampling method. Research instrument with VAS observation sheet

Results: Pretest results showed moderate pain (81.8%), and severe pain at 18.2%. After being given cupping therapy the results of the posttest score were obtained with minor pain results of 100.0%, which means that there is a decrease in knee pain for patients with osteoarthritis.

Conclusion: There was a decrease in the level of knee pain after being given dry cupping therapy
Do Technological Developments Increase Unemployment? Investigation Of Technological Developments, Education, Job Participation, And Unemployment In Thailand
Authors:   European School of Economics, Italy, Laura Claudia , Choi Chaem ,   Thammasat Business School, Thailand
Published: August 2022

This study investigates technological developments, work participation, education, and unemployment where each variable is investigated carefully, especially the relationship between variables. In order to investigate the causal link between variables, this study employs a time frame of 21 years, from 2000 to 2020, and uses the autoregressive vector quantitative approach. This study uses secondary data from the world bank with the control variables being internet literacy, Economics participation, education, and unemployment in Thailand. We found that technological developments in Thailand do not threaten to increase unemployment. Where with the development of technology new jobs are created and the role of education in human capital investment becomes important in increasing human ability to master technology and use technology optimally so that technological developments also increase economic participation. Economic participation is an indicator of labor participation and employment.
The Digital Economy and the Importance of Technology in Economic Growth
Authors:   STIE Jaya Negara Tamansiswa Malang,Indonesia, Hadi Prabowo Bambang
Published: August 2022

This study investigates internet users, economic growth and digital. This study investigates data at the start point year of 2000 to 2020 to generate "autoregressive vectors" that can be utilize for determine relationship among the variables. This model is to analyze among growth of the economic, the individual user from internet, also there is digital economic spending at Indonesia using secondary data from the World Bank. We discovered there is a development of digital economy who has a substantial and has influence on the growth of economic, implying that there is digital economy is critical to economic progress, but the growth of the modern economy cannot being separated from the influence of internet users. This study proves that a decrease in internet users will increase economic growth, just as an increase in the economy when it declines will lead to an increase in internet users.
Interest Rates and Burden of Economics in Thailand
Authors:   STIE Jaya Negara Tamansiswa Malang,Indonesia, Sulisnaningrum Ema , Puspaningtyas Meinarti
Published: August 2022

This research tries to investigate how interest rates affect economic performance by using indicators of GDP, consumption, investment and interest rates. The World Bank provided secondary data for our study, which has an annual study period from 2000 to 2020. We use vector analysis for estimate data. We found that Investments encourage economic growth, although, in Thailand, domestic consumption does not necessarily encourage economic growth. This is very surprising because it is a different finding. However, interest rates suppress all sectors, both in the market sector, namely consumption, the financial sector, namely investment, and the production sector, namely GDP. GDP itself is an indicator of economic growth. Interest rates are a depressant and a burden on the economy in Thailand so low-interest rates and being managed carefully are the policies we recommend for economic recovery in Thailand.
The Role Of Education And Health In Work Participation In Cambodia
Authors:   Universitas 17 Agustus 1945 Banyuwangi, Indonesia, Taufik Widianto Adita , Chanthavy Achariya ,   Royal University of Law and Economics, Cambodia
Published: August 2022

This study's goal is to determine how the role of investment in health and education on job participation in Cambodia. This study examines investment in education, investment in health, and the number of Cambodian residents who work or are absorbed as laborers in Cambodia. This study uses secondary data from the world bank. We use behavioral data analysis with the Threshold Autoregressive model. The research period in this study is the annual period from 2000 to 2019.We found that employment in Cambodia is impacted by investments in health and education. Education is able to increase human capital so that people can find suitable and more productive jobs and jobs that require experts are increasingly filled, this increases work participation while increasing economic performance. Health itself keeps the community healthy and can still work productively so that it can increase the work participation of the Cambodian community
Handling Inflation In The World Of Marketing By Using Communication And Information Technology And Its Impact On Economic Growth
Authors:   STIE Jaya Negara Tamansiswa Malang, Indonesia, Damayanti Lina
Published: August 2022

This study examines Inflation, Communication and Information Technology, Marketing and Economic Growth, and the connection among them. This study investigates data from the 2000 to 2020 starting point to generate “autoregressive vectors” that can be used to determine relationships between variables. This model is used to analyze Inflation, Information Communication and Technology, Marketing and Economic Growth in Indonesia using secondary data from the World Bank. We find that Inflation can reduce the quality of economic development in each period from the beginning to the end, but inflation can be overcome with the existence of Information Communication and Technology, not only that Information Communication and Technology also helps in the development of a Marketing in Indonesia which has resulted in increased economic growth in Indonesia.
Participación de las empresas en la gestión de la seguridad y salud en el trabajo en Colombia
Authors: Ospina Cardozo Juli Jessenia , Mazo Bedoya Luz Alicia , Varón Morales Luz Patricia
Published: August 2022

Durante la construcción de este documento, se analizó la participación por parte de las empresas en la administración en la gestión de la seguridad y salud en el trabajo, a partir del análisis de la información, presente en reseñas informativas como revistas, libros, artículos, páginas web, etc., con temas de importancia como los indicadores de accidentalidad y enfermedades laborales, reportadas por las fuentes estadísticas existentes en Colombia. Con lo anterior se procedió a indagar si existe participación alguna de las empresas en el campo de evaluación y aporte a la mejora de las normas y el concepto que tienen sobre la evolución de la gestión de la seguridad y salud en el trabajo con el objeto de conocer cómo han intervenido éstas en el cuidado y protección de la salud y bienestar de sus trabajadores, respecto al sistema de gestión en seguridad y salud en el trabajo, o anteriormente llamado, programas de salud ocupacional y en la aplicación de las normas que se han desarrollado durante la trayectoria de la legislación laboral que ha tenido Colombia. Esta investigación se realizó en la ciudad de Cali, a través de las herramientas ya mencionadas.
Modelo teórico curricular para la transformación del talento humano en la universidad compleja
Authors: Majad Rondón Musa Ammar 
Published: August 2022

Esta investigación tuvo como propósito construir un modelo teórico curricular para la transformación del talento humano en la universidad compleja, bajo el enfoque de las teorías humanista, de sistemas y de la complejidad. La importancia refiere al estudio de las dificultades curriculares que afectan la transformación del talento humano en el ámbito universitario, específicamente en la carrera de Administración, mención Relaciones Industriales, de la Universidad Alonso de Ojeda, en San Cristóbal, estado Táchira. Se apoyó en el paradigma postpositivista; siendo un estudio de campo, de naturaleza descriptiva, evaluativo-explicativo, con enfoque hermenéutico, adoptando el método etnográfico, con el enfoque cualitativo, complementado con técnicas e instrumentos cuantitativos y desarrollando el modelo de evaluación curricular de Stufflebeam y Shinkfield (1989). Los sujetos se conformaron en los estratos coordinador, docente y estudiante. Las técnicas fueron la entrevista a profundidad y el cuestionario. Se obtuvo la necesidad de reforzar la educación como actividad planificada; se determinaron debilidades internas en los procesos educativos transformadores del hombre, entendiendo que se trata de un sujeto que ha de ver, pensar y actuar para servir y transformar los componentes internos de su propio ser y la sociedad, con compromiso, valor ético, responsabilidad y pertinencia; esto, en una institución con proyección poco significativa en el entorno. Se realizaron recomendaciones y se presentó la construcción del modelo curricular.
Creating an atmosphere of enthusiasm and motivation in the classroom
Authors: Rivera Quintero Rosario , Useche Ospinal Verónica 
Published: August 2022

En el ámbito educativo actual, la figura del docente está siendo cada vez más desestimada por parte de los mismos estudiantes, lo cual ha ido generando una serie de factores que hacen que ellos ya no se sientan motivados por aprender o encuentren diversas excusas para no querer apropiarse de sus conocimientos. A través de éste artículo, se pretende concientizar, animar y ayudar al maestro a apropiarse de su rol y ejercerlo de tal forma que pueda ser un canal que estimule el aprendizaje en sus estudiantes sin que ellos se sientan presionados ni obligados. Los tres componentes mencionados en el artículo y que ayudarán a abordar este tema son: creatividad, innovación y estimulación intelectual. Si bien en el proceso de formación, éstos deben ser desarrollados de forma conectada, muchos los ven como factores aislados entre sí o no interconectados. La correlación que estos tres elementos poseen es primordial en el manejo y organización al interior de las aulas, ya que tiene como fin interesar a los aprendices a ser más conscientes y a involucrarse más en su propio aprendizaje, sintiéndose responsables de cumplir las metas u objetivos propuestos y estimulando sus capacidades en el logro de los mismos. Por otro lado, reconocer la importancia del rol del docente, su pasión por enseñar y formar, son puntos claves para la creación de ambientes motivacionales y entusiastas, ya que esto conlleva a que los estudiantes asimilen y se interesen por aprender de manera más natural y fresca sin dejar de lado la exigencia y excelencia en cada uno de los procesos.
Efectos adversos de la estabilidad laboral reforzada para una organización
Authors: Santos Ortiz Natalia
Published: August 2022

Las organizaciones han generado constantes debates sobre las implicaciones del término jurisprudencial de estabilidad laboral reforzada, que se le otorga a un trabajador como mecanismo de protección para no ser despedido cuando se encuentre en estado de vulnerabilidad manifiesta, preservando sus principios y derechos Constitucionales. El objetivo del presente artículo es analizar los efectos adversos en los procesos organizacionales y económicos de la estabilidad laboral reforzada para una organización. Para ello, se llevó a cabo un diseño de investigación documental de tipo jurídico con un enfoque cualitativo. Como resultado, se evidenció que los efectos económicos con relación a costos percibidos por las empresas en un caso de estabilidad laboral reforzada no se pueden cuantificar con exactitud, debido a que dependen de variables características o propias de cada organización como, por ejemplo: el tipo de protección que adquiere el empleado, el tipo de cargo que ocupa, el salario que devenga, el tipo de contrato por el cual estaba vinculado, etc., lo que obliga a las organizaciones a tomar medidas preventivas reestructurando sus procesos de selección y contratación mediante la creación de sistemas de seguridad y salud en el trabajo con el fin de anticipar, reconocer, evaluar y controlar la existencia de sujetos propensos a una estabilidad laboral reforzada. Los resultados comprometen a las organizaciones a crear estrategias que permitan maniobrar y enfrentar los retos jurídicos y económicos de la estabilidad laboral reforzada con el fin de mantener la eficiencia, efectividad y productividad organizacional.