bluuebunny/crossref_metadata_2025 huggingface dataset:
Transition Metal Oxides for Organic Electronics: Energetics, Device Physics and Applications
Authors: Meyer Jens , Hamwi Sami , Kröger Michael , Kowalsky Wolfgang , Riedl Thomas , Kahn Antoine
Published: August 2012

During the last few years, transition metal oxides (TMO) such as molybdenum tri‐oxide (MoO3), vanadium pent‐oxide (V2O5) or tungsten tri‐oxide (WO3) have been extensively studied because of their exceptional electronic properties for charge injection and extraction in organic electronic devices. These unique properties have led to the performance enhancement of several types of devices and to a variety of novel applications. TMOs have been used to realize efficient and long‐term stable p‐type doping of wide band gap organic materials, charge‐generation junctions for stacked organic light emitting diodes (OLED), sputtering buffer layers for semi‐transparent devices, and organic photovoltaic (OPV) cells with improved charge extraction, enhanced power conversion efficiency and substantially improved long term stability. Energetics in general play a key role in advancing device structure and performance in organic electronics; however, the literature provides a very inconsistent picture of the electronic structure of TMOs and the resulting interpretation of their role as functional constituents in organic electronics. With this review we intend to clarify some of the existing misconceptions. An overview of TMO‐based device architectures ranging from transparent OLEDs to tandem OPV cells is also given. Various TMO film deposition methods are reviewed, addressing vacuum evaporation and recent approaches for solution‐based processing. The specific properties of the resulting materials and their role as functional layers in organic devices are discussed.
Simultaneous Open‐Circuit Voltage Enhancement and Short‐Circuit Current Loss in Polymer: Fullerene Solar Cells Correlated by Reduced Quantum Efficiency for Photoinduced Electron Transfer
Authors: Di Nuzzo Daniele , Wetzelaer Gert‐Jan A. H. , Bouwer Ricardo K. M. , Gevaerts Veronique S. , Meskers Stefan C. J. , Hummelen Jan C. , Blom Paul W. M. , Janssen René A. J.
Published: August 2012

The limits of maximizing the open‐circuit voltage Voc in solar cells based on poly[2,7‐(9,9‐didecylfluorene)‐alt‐5,5‐(4,7‐di‐2‐thienyl‐2,1,3‐benzothiadiazole)] (PF10TBT) as a donor using different fullerene derivatives as acceptor are investigated. Bulk heterojunction solar cells with PF10TBT and [6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM) give a Voc over 1 V and a power conversion efficiency of 4.2%. Devices in which PF10TBT is blended with fullerene bisadduct derivatives give an even higher Voc, but also a strong decrease in short circuit current (Jsc). The higher Voc is attributed to the higher LUMO of the acceptors in comparison to PCBM. By investigating the photophysics of PF10TBT:fullerene blends using near‐IR photo‐ and electroluminescence, time‐resolved photoluminescence, and photoinduced absorption we find that the charge transfer (CT) state is not formed efficiently when using fullerene bisadducts. Hence, engineering acceptor materials with a LUMO level that is as high as possible can increase Voc, but will only provide a higher power conversion efficiency, when the quantum efficiency for charge transfer is preserved. To quantify this, we determine the CT energy (ECT) and optical band gap (Eg), defined as the lowest first singlet state energy ES1 of either the donor or acceptor, for each of the blends and find a clear correlation between the free energy for photoinduced electron transfer and Jsc. We find that Eg − qVoc > 0.6 eV is a simple, but general criterion for efficient charge generation in donor‐acceptor blends.
A target‐oriented solid‐gas thermochemical sorption heat transformer for integrated energy storage and energy upgrade
Authors: Li Tingxian , Wang Ruzhu , Kiplagat Jeremiah K.
Published: August 2012

An innovative target‐oriented solid‐gas thermochemical sorption heat transformer is developed for the integrated energy storage and energy upgrade of low‐grade thermal energy. The operating principle of the proposed energy storage system is based on the reversible solid‐gas chemical reaction whereby thermal energy is stored in form of chemical bonds with thermochemical sorption process. A novel thermochemical sorption cycle is proposed to upgrade the stored thermal energy by using a pressure‐reducing desorption method during energy storage process and a temperature‐lift adsorption technique during energy release process. Theoretical analysis showed that the proposed target‐oriented thermochemical sorption heat transformer is effective for the integrated energy storage and energy upgrade, and the low‐grade thermal energy can be upgraded from 87 to 171°C using a group of sorption working pair MnCl2‐CaCl2‐NH3. Moreover, it can give the flexibility of deciding the temperature magnitude of energy upgrade by choosing appropriate sorption working pairs. © 2012 American Institute of Chemical Engineers AIChE J, 59: 1334–1347, 2013
Kinetics study and crystallization process design for scale‐up of UiO‐66‐NH2 synthesis
Authors: Schoenecker Paul M. , Belancik Grace A. , Grabicka Bogna E. , Walton Krista S.
Published: August 2012

A comprehensive scale‐up procedure for amine‐functionalized UiO‐66 is implemented, which leads to the development of a novel flow‐through metal‐organic framework synthesis process. Products are characterized via BET modeling of N2 adsorption at 77 K and powder XRD to confirm crystal porosity and phase, respectively. Batch syntheses are conducted to examine the effects of polytetrafluoroethylene and glass vessel materials on crystal yield and quality. Intermediate samples from sealed‐vessel trials at 373, 383, and 393 K are collected and characterized, which show a high degree of product consistency. Nucleation rates are determined at the same temperatures, and the Arrhenius relationship is used to predict the activation energy of nucleation, EaNuc. A continuous‐flow reactive crystallization process is developed using a draft‐tube type reactor. As a proof of concept, the reactor is operated for three retention times. The cumulative product, material retained within the crystallizer, and intermediate samples are collected and characterized to confirm UiO‐66‐NH2 production. © 2012 American Institute of Chemical Engineers AIChE J, 59: 1255–1262, 2013
Synergistic anticancer effects of arsenic trioxide with bortezomib in mantle cell lymphoma
Authors: Jung Hyun Joo , Chen Zheng , McCarty Nami
Published: August 2012

Mantle cell lymphoma (MCL) is a subtype of B‐cell Non‐Hodgkin's Lymphoma (NHL) and accounts for ∼6% of all lymphomas. MCL is highly refractory to most chemotherapy including newer antibody‐based therapeutic approaches, and high‐grade MCL has one of the worst survival rates among NHLs. Therefore, the development of new therapeutic strategies to overcome drug resistance of MCL is important. In this article, we tested the effects of arsenic trioxide (As2O3, ATO) in bortezomib‐resistant MCL. ATO is reported to induce complete remission in the patients with relapsed or refractory acute promyelocytic leukemia. Their effects in MCL, however, have not been explored. In this report, we show that ATO effectively inhibited the growth of MCL cells in vitro. ATO treatment also reduced cyclin D1 expression which is a genetic hallmark of MCL and NF‐kB expression which was reported to have a prosurvival role in some MCL cells. The induction of apoptosis in MCL was partially due to reduced levels of cyclin D1 and increased levels of apoptosis‐related molecules. The antiproliferative effects of bortezomib on MCL greatly increased when the cells were also treated with ATO, indicating ATO can sensitize MCL to bortezomib. Similar results were noted in bortezomib‐resistant cell lines. In conclusion, ATO may be an alternative drug for use in combined adjuvant therapies for MCL, and further clinical testing should be performed. Am. J. Hematol., 2012. © 2012 Wiley Periodicals, Inc.
Severe lateral tibial bowing with short stature in two siblings—A provisionally novel syndrome
Authors: Zitano Lia , Loder Randall T. , Cohen Mervyn D. , Weaver David D.
Published: August 2012

In this report, we describe two siblings with short stature and severe lateral tibial bowing. In the younger sibling, the bowing was bilateral, while in the older sib, it was unilateral. However, both showed bilateral abnormalities of the distal tibial epiphyses and growth plates. Pseudoarthrosis of the left distal tibial metaphysis and subsequent spontaneous resolution of the abnormality occurred in the younger sibling. The fibulas of both children were of normal diameter and were straight, except for the distal ends. Surgery has almost completely corrected the lower leg bowing in both patients. The type of tibial bowing seen in these children can be associated with a number of syndromes, such as neurofibromatosis type I, Weismann–Netter syndrome, and a variety of environmental caused disorders, such as vitamin D deficient rickets. However, the severity of the bowing present in our patients and the absence of other clinical features differentiates this condition from those reported in the literature. We posit that the condition in the children presented here represents an as yet undescribed syndrome, which is likely to be of genetic origin. © 2012 Wiley Periodicals, Inc.
Syntheses, structures of N‐(substituted)‐2‐aza‐[3]‐ferrocenophanes and their application as redox sensor for Cu2+ ion
Authors: Chen Lianmei , Cui Xiuling , Cheng Haitao , Chen Xiaopei , Song Maoping , Tang Mingsheng , Wei Donghui , Wu Yangjie
Published: August 2012

Rigid N‐(substituted)‐2‐aza‐[3]‐ferrocenophanes L1 and L2 were easily synthesized from 1,1 ‐dicarboxyaldehydeferrocene and the corresponding amines. Ligands L1 and L2 were characterized by 1H NMR, 13C NMR and single‐crystal X‐ray crystallography. The coordination abilities of L1 and L2 with metal ions such as Cu2+, Mg2+, Ni2+, Zn2+, Pb2+ and Cd2+ were evaluated by cyclic voltammetry. The electrochemical shift (ΔE1/2) of 125 mV was observed in the presence of Cu2+ ion, while no significant shift of the Fc/Fc + couple was observed when Mg2+, Ni2+, Zn2+, Pb2+, Cd2+ metal ions were added to the solution of L1 in the mixture of MeOH and H2O. Moreover, the extent of the anodic shift of redox potentials was approximately equal to that induced by Cu2+ alone when a mixture of Cu2+, Mg2+, Ni2+, Zn2+, Pb2+ and Cd2+ was added to a solution of L1. Ligand L1 was proved to selectively sense Cu2+ in the presence of large, excessive first‐row transition and late‐transition metal cations. The coordination model was proposed from the results of controlled experiments and quantum calculations. Copyright © 2012 John Wiley & Sons, Ltd.
Semidry synthesis of the poly(acrylic acid)/palygorskite superabsorbent with high‐percentage clay via a freeze–thaw–extrusion process
Authors: Chen Jing , Ding Shijie , Jin Yeling , Wu Jie
Published: August 2012

A problem with the synthesis of polymer/clay composites is the poor compatibility between clay and polymers; this is particularly bad for those with a high percentage of clay. In response, we introduced a freeze–thaw–extrusion process before polymerization to make the best use of the high activation ability of acrylic acid (the monomer) and the exceptional hydration of palygorskite (clay). This processing was powerful for facilitating clay dispersed into the nanoscale and for obtaining good compatibility with the polymer, even for those polymers with high clay contents. The experiment showed that the quality of the consequent superabsorbent was improved significantly. As the dispersion was worked out perfectly by the freeze–thaw–extrusion process, we further explored the effect of the system water content on the water absorptivity of the consequent composite. With synthesis by the improved system, the water absorbency still amounted to 98.2 g/g in a 0.9 wt % NaCl solution for the composite with 35 wt % clay, whereas the water content (55 wt %) was much less than that of general synthesis (ca. 95 wt %). Scanning electron microscopy showed that the composite had a rich pore structure in the range of several hundred nanometers, and the palygorskite was distributed perfectly in the composite on the nanoscale. Fourier transform infrared spectroscopy gave further direct evidence for the reaction between the clay and polymer. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Novel benzoxazine resins as photoinitiator comprising benzophenone and coinitiator amine for photopolymerization
Authors: Bai Jing , Shi Zixing
Published: August 2012

A novel kind of benzoxazine precursors made of 4‐dihydroxybenzophenone (DHBP), formaldehyde and N, N′‐diethylethylenediamine was developed. The striking feature of this class of precursors is that it can be acted as an effective photo initiator for polymerization of acrylate monomers. In addition, this kind of precursors could be directly dispersed in water and its aqueous solution exhibited very sharp response to temperature, with a well‐defined cloud point. The structure of this precursor has been confirmed by Proton Nuclear Magnetic Resonance Spectroscopy (1H‐NMR) and Fourier Transform Infrared spectroscopy (FTIR) and its curing behaviors are investigated by Differential Scanning Calorimetry (DSC). The photopolymerization of acylate monomers, initiated by this precursor, was studied through photo‐DSC. The results show that this precursor is dramatically more efficient than benzophenone (BP), in which the polymerization rate is almost four times as high as that of the BP system. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Absorption characterization of Ca2+, Na+, and K+ on irradiation crosslinked carboxymethyl sago pulp hydrogel
Authors: Pushpamalar Vengidesh , Langford Steven James , Ahmad Mansor , Hashim Kamaruddin , Lim Yau Yan
Published: August 2012

Hydrogel of carboxymethyl sago pulp (CMSP) of various degree of substitution (DS) was prepared by electron beam irradiation of various radiation doses. The CMSP hydrogels were subjected to swelling in different ionic strength solutions of KCl, NaCl, and CaCl2. The CMSP hydrogels, due to its polyelectrolyte nature, were found to be highly sensitive to ionic strength of the medium. All the CMSP hydrogels showed the absorption of K+ and Ca2+ increases with the increase in the concentrations of the respective cation solutions. The cation absorption also decreases with DS and % gel fraction (%GF) of the CMSP hydrogels. Subjecting the CMSP hydrogels in NaCl results in deswelling and releases Na+ to swelling medium where the Na+ release increases with the increase of DS and %GF. The sorption capacity depends on the extent of crosslinking and decreases with the increase in the extent of crosslinking. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Synthesis and characterization of molybdenum‐modified polycarbosilane for SiC(Mo) ceramics
Authors: Xie Zhengfang , Niu Jiaxin , Chen Zhaohui
Published: August 2012

A novel molybdenum‐containing polycarbosilane, polymolybdenocarbosilane (PMoCS), for SiC(Mo) fiber has been synthesized from polysilacarbosilane (PSCS) and MoCl5 as raw materials. The synthesis conditions is investigated. Characterization performed on the as‐synthesized PMoCS includes Fourier Transformed Infrared Spectroscopy (FT IR), gel‐permeation chromatography (GPC), X‐ray photoelectron spectroscopy (XPS), 1H NMR, and 29Si NMR, respectively. The polymer‐to‐ceramic conversion is studied with thermogravimetric analysis (TGA) and X‐ray diffraction  (XRD). Preliminary research on the melt spinnability of PMoCS is carried out. The results show that the synthesis reaction is temperature‐dependent. Mo exists mainly as SiMo bonds. The reaction mechanism is believed to involve HCl elimination between SiH and MoCl, and followed by the Kumada rearrangement. The ceramic yield of PMoCS, prepared with 10 wt % MoCl5, is approximately 78.5% at 1200°C in a N2 flow. The XRD results suggest that ceramics pyrolyzed in the range of 800–1000°C are all amorphous, while β‐SiC and β‐MoSi2 crystals are observed at 1200 and 1400°C, respectively. The conversion from β‐MoSi2 to α‐MoSi2 is almost completed at 1600°C. PMoCS is melt spinnable into flexible and uniform green fibers with the diameters about 13.4 μm to 12.2 μm. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Delay Approximation of Fractional Integrals
Authors: Machado J. A. Tenreiro
Published: August 2012

This paper explores the calculation of fractional integrals by means of the time delay operator. The study starts by reviewing the memory properties of fractional operators and their relationship with time delay. Based on the time response of the Mittag‐Leffler function an approximation of fractional integrals consisting of time delayed samples is proposed. The tuning of the approximation is optimized by means of a genetic algorithm. The results demonstrate the feasibility of the new perspective and the limits of their application.
Was steuert das Pflanzenwachstum?
Authors: Koerner Christian
Published: August 2012

Die Photosynthese ist zwar ein unerlässlicher Prozess, ohne den keine Pflanze wachsen kann, sie ist aber nur selten der limitierende Faktor für das Pflanzenwachstum. Vielmehr beschränken Wasser‐ und Nährstoffmangel sowie niedrige Temperatur die zellulären Prozesse der Gewebebildung direkt und wesentlich ausgeprägter, weshalb die Rate der Gewebebildung in aller Regel bestimmt, wieviel Photosyntheseprodukte (Zucker) verwertet (und erzeugt) werden können.
Impact of lymphadenectomy on survival after surgery for sporadic gastrinoma
Authors: Bartsch D K , Waldmann J , Fendrich V , Boninsegna L , Lopez C L , Partelli S , Falconi M
Published: August 2012

Background

The study was undertaken to determine prognostic factors and the value of systematic lymphadenectomy on survival in sporadic gastrinoma.

Methods

Patients with sporadic gastrinoma who underwent initial surgery during a 21-year period in two tertiary referral centres were analysed retrospectively with respect to clinical characteristics, operative procedures and outcome.

Results

Forty-eight patients with a median age of 52 (range 22–73) years were analysed. Some 18 patients had pancreatic and 26 had duodenal gastrinomas, whereas the primary tumour remained unidentified in four patients. After a median postoperative follow-up of 83 (range 3–296) months, 20 patients had no evidence of disease, 13 patients were alive with disease, 11 patients had died from the disease and four had died from unrelated causes. In 41 patients who underwent potentially curative surgery, systematic lymphadenectomy with excision of more than ten lymph nodes resulted in a higher rate of biochemical cure after surgery than no or selective lymphadenectomy (13 of 13 versus 18 of 28 patients; P = 0·017), with a trend towards prolonged disease specific survival (P = 0·062) and disease-free survival (P = 0·120), and a reduced risk of death (0 of 13 versus 7 of 24 patients; P = 0·037). Negative prognostic factors for disease specific survival were pancreatic location (P = 0·029), tumour size equal to or larger than 25 mm (P = 0·003), Ki-67 index more than 5 per cent (P < 0·001), preoperative gastrin level 3000 pg/ml or more (P = 0·003) and liver metastases (P < 0·001). Sex, age, type of surgery and presence of lymph node metastases had no influence on disease free or disease specific survival.

Conclusion

In sporadic gastrinoma, systematic lymphadenectomy during initial surgery may reduce the risk of persistent disease and improve survival.
Role of patient-specific virtual reality rehearsal in carotid artery stenting
Authors: Willaert W I M , Aggarwal R , Van Herzeele I , Plessers M , Stroobant N , Nestel D , Cheshire N , Vermassen F
Published: August 2012

Background

Recent advances in simulation science permit patient-specific rehearsal of endovascular stenting procedures. This study aimed to evaluate how effectively real interventions are replicated by patient-specific rehearsal technology, and to assess its value as a preparatory tool for the interventionalist and the operating team.

Methods

All patients deemed candidates for carotid artery stenting procedures with suitable computed tomography images were enrolled. Each team member rehearsed the virtual procedure in the laboratory, simulated operating theatre or angiography suite environment immediately before treating the real patient. Dexterity and qualitative metrics were recorded. Subjective questionnaires used a Likert scale from 1 (poor) to 5 (excellent).

Results

Of 18 patients, three were excluded. In 11 of 15 and 13 of 15 patients respectively endovascular tool use and fluoroscopy angles were identical during rehearsal and the real procedure. In a third of patients, the simulator did not adequately predict difficulties in cannulating the stenotic internal or common carotid arteries. The procedure realism, value in evaluating the case, increase in efficiency in tool use, and potential to increase communication, confidence and team performance were all rated highly (4 of 5).

Conclusion

Patient-specific rehearsal was rated highly for both face and content validity. Access strategy, endovascular material use and angiographic imaging were all replicated effectively, although certain biomechanical vessel properties seemed to be replicated to a lesser degree. Patient-specific rehearsal constitutes a unique tool that may help tailor endovascular material choice, and optimize the preoperative preparation of the interventionalist and team.
Blaming the Messenger for the Bad News about Partner Violence by Women: The Methodological, Theoretical, and Value Basis of the Purported Invalidity of the Conflict Tactics Scales
Authors: Straus Murray A.
Published: August 2012

More than 200 studies have found “gender symmetry” in perpetration of violence against a marital or dating partner in the sense that about the same percent of women as men physically assault a marital or dating partner. Most of these studies obtained the data using the Conflict Tactics Scales (CTS). However, these results have been challenged by numerous articles in the past 25 years that have asserted that the CTS is invalid. This article identifies and responds to 11 purported methodological problems of the CTS, and two other bases for the belief that the CTS is not valid. The discussion argues that the repeated assertion over the past 25 years that the CTS is invalid is not primarily about methodology. Rather it is primarily about theories and values concerning the results of research showing gender symmetry in perpetration. According to the prevailing “patriarchal dominance” theory, these results cannot be true and therefore the CTS must be invalid. The conclusion suggests that an essential part of the effort to prevent and treat violence against women and by women requires taking into account the dyadic nature of partner violence through use of instruments such as the CTS that measure violence by both partners. Copyright © 2012 John Wiley & Sons, Ltd.
The involvement of AQP1 in heart oedema induced by global myocardial ischemia
Authors: Ding Fang‐Bao , Yan Yu‐Mei , Huang Jian‐Bin , Mei Ju , Zhu Jia‐Quan , Liu Hao
Published: August 2012

Aquaporin‐1 (AQP1) is a member of aquaporin family that was previously proven to be involved in myocardial dysfunction; however, the role of AQP1 in myocardial stunning is less clear. To determine the change of AQP1 expression level in the heart and its effect on oedema after global myocardial ischemia, 40 adult goats underwent cardiopulmonary bypass (CPB) with an aortic cross‐clamp time of 2 h and total bypass time of 6, 12, 24, 48 and 72 h followed by subsequent reperfusion. AQP1 function of eight goats was inhibited by HgCl2 during the 24 h on CPB. All groups were compared with eight sham bypass control goats. Myocardial water content was measured, and the APQ1 mRNA and protein levels were detected by RT‐PCR and immunoblotting, respectively. The results showed that the degree of myocardial oedema increased significantly at 6, 12, 24 and 48 h of reperfusion after CPB as compared with the control and recovered at 72 h of subsequent reperfusion. Expression levels of AQP1 mRNA and protein began to increase at 12 h and peaked at 24 h of CPB following reperfusion. Furthermore, myocardial oedema was reduced in the HgCl2 group compared with the time‐matched CPB and control groups. These data suggested that AQP1 expression increases in CPB and AQP1 plays an important role in myocardial oedema during CPB. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis of trans‐Disubstituted Alkenes by Cobalt‐Catalyzed Reductive Coupling of Terminal Alkynes with Activated Alkenes
Authors: Mannathan Subramaniyan , Cheng Chien‐Hong
Published: August 2012

A cobalt‐catalyzed reductive coupling of terminal alkynes, RCCH, with activated alkenes, R′CHCH2, in the presence of zinc and water to give functionalized trans‐disubstituted alkenes, RCHCHCH2CH2R′, is described. A variety of aromatic terminal alkynes underwent reductive coupling with activated alkenes including enones, acrylates, acrylonitrile, and vinyl sulfones in the presence of a CoCl2/P(OMe)3/Zn catalyst system to afford 1,2‐trans‐disubstituted alkenes with high regio‐ and stereoselectivity. Similarly, aliphatic terminal alkynes also efficiently participated in the coupling reaction with acrylates, enones, and vinyl sulfone, in the presence of the CoCl2/P(OPh)3/Zn system providing a mixture of 1,2‐trans‐ and 1,1‐disubstituted functionalized terminal alkene products in high yields. The scope of the reaction was also extended by the coupling of 1,3‐enynes and acetylene gas with alkenes. Furthermore, a phosphine‐free cobalt‐catalyzed reductive coupling of terminal alkynes with enones, affording 1,2‐trans‐disubstituted alkenes as the major products in a high regioisomeric ratio, is demonstrated. In the reactions, less expensive and air‐stable cobalt complexes, a mild reducing agent (Zn) and a simple hydrogen source (water) were used. A possible reaction mechanism involving a cobaltacyclopentene as the key intermediate is proposed.
An Isoreticular Family of Microporous Metal–Organic Frameworks Based on Zinc and 2‐Substituted Imidazolate‐4‐amide‐5‐imidate: Syntheses, Structures and Properties
Authors: Debatin Franziska , Behrens Karsten , Weber Jens , Baburin Igor A. , Thomas Arne , Schmidt Johannes , Senkovska Irena , Kaskel Stefan , Kelling Alexandra , Hedin Niklas , Bacsik Zoltan , Leoni Stefano , Seifert Gotthard , Jäger Christian , Günter Christina , Schilde Uwe , Friedrich Alwin , Holdt Hans‐Jürgen
Published: August 2012

We report on a new series of isoreticular frameworks based on zinc and 2‐substituted imidazolate‐4‐amide‐5‐imidate (IFP‐1–4, IFP=imidazolate framework Potsdam) that form one‐dimensional, microporous hexagonal channels. Varying R in the 2‐substitued linker (R=Me (IFP‐1), Cl (IFP‐2), Br (IFP‐3), Et (IFP‐4)) allowed the channel diameter (4.0–1.7 Å), the polarisability and functionality of the channel walls to be tuned. Frameworks IFP‐2, IFP‐3 and IFP‐4 are isostructural to previously reported IFP‐1. The structures of IFP‐2 and IFP‐3 were solved by X‐ray crystallographic analyses. The structure of IFP‐4 was determined by a combination of PXRD and structure modelling and was confirmed by IR spectroscopy and 1H MAS and 13C CP‐MAS NMR spectroscopy. All IFPs showed high thermal stability (345–400 °C); IFP‐1 and IFP‐4 were stable in boiling water for 7 d. A detailed porosity analysis was performed on the basis of adsorption measurements by using various gases. The potential of the materials to undergo specific interactions with CO2 was investigated by measuring the isosteric heats of adsorption. The capacity to adsorb CH4 (at 298 K), CO2 (at 298 K) and H2 (at 77 K) at high pressure were also investigated. In situ IR spectroscopy showed that CO2 is physisorbed on IFP‐1–4 under dry conditions and that both CO2 and H2O are physisorbed on IFP‐1 under moist conditions.
Formal Synthesis of Dictyostatin and Synthesis of Two Dictyostatin Analogues
Authors: Gallon Julien , Esteban Jorge , Bouzbouz Samir , Campbell Matthew , Reymond Sébastien , Cossy Janine
Published: August 2012

A formal convergent synthesis of dictyostatin from (R)‐Roche ester is described. Synthetic highlights include a Ni‐catalyzed Nozaki–Hiyama–Kishi coupling between an aldehyde and a Z vinyl iodide to assemble the two main fragments, a diastereoselective Myers alkylation, a stereoselective Evans aldolization, two asymmetric Duthaler crotyltitanations, and a stereoselective Pd‐catalyzed Marshall allenylindium addition to install the stereogenic centers of dictyostatin. The synthesis of (9R)‐epi‐dictyostatin and a new ring‐contracted dictyostatin isomer were also achieved.
ChemInform Abstract: The Fluorite Related Modulated Structures of the Gd2(Zr2‐xCex)O7 Solid Solution: An Analogue for Pu Disposition.
Authors: Reid D. P. , Stennett M. C. , Hyatt N. C.
Published: August 2012

The fluorite‐related structures of the Gd2(Zr2‐xCex)O7 (0 ≤ x ≤ 2) solid solution, of interest as a model system for ceramic disposition of Pu (with Ce as a Pu surrogate), are determined by XRD, XANES, TEM, and EELS.
ChemInform Abstract: Structural and Physical Properties of Layered Oxy‐Arsenides LnRuAsO (Ln: La, Nd, Sm, Gd).
Authors: McGuire Michael A. , May Andrew F. , Sales Brian C.
Published: August 2012

The title compounds are characterized by powder XRD, electrical transport, magnetization, and heat capacity measurements.
ChemInform Abstract: Crystal Structures and Magnetic Properties of Strontium and Copper Doped Lanthanum Ferrites.
Authors: Sora Isabella Natali , Caronna Tullio , Fontana Francesca , Fernandez Cesar de Julian , Caneschi Andrea , Green Mark
Published: August 2012

The crystallographic and magnetic structures of La0.8Sr0.2Fe1‐xCuxO3‐w (x = 0.05, 0.10, 0.20) are determined by neutron powder diffraction at room temperature.
ChemInform Abstract: Magnetic and Electrical Properties of UCr2Al20 Single Crystals.
Authors: Swatek P. , Kaczorowski D.
Published: August 2012

Single crystals of the title compound are prepared from the elements using excess Al as a flux.
ChemInform Abstract: Carbonophosphates: A New Family of Cathode Materials for Li‐Ion Batteries Identified Computationally.
Authors: Ceder Gerbrand , et al. et al.
Published: August 2012

A new class of materials which can intercalate lithium reversibly is discovered by a novel high‐throughput ab initio computational approach.
ChemInform Abstract: The Elusive Tetrasulfate Anion [S4O13]2‐.
Authors: Logemann Christian , Kluener Thorsten , Wickleder Mathias S.
Published: August 2012

(NO2)2[S4O13], the first tetrasulfate reported so far, is synthesized by reaction of N2O5 with a large excess of SO3 (80 °C, 24 h).
ChemInform Abstract: Sr7Ge6, Ba7Ge6 and Ba3Sn2 — Three New Binary Compounds Containing Dumbbells and Four‐Membered Chains of Tetrel Atoms with Considerable Ge—Ge π‐Bonding Character.
Authors: Siggelkow Lisa , Hlukhyy Viktor , Faessler Thomas F.
Published: August 2012

The title compounds are prepared by arc‐melting of the elements followed by annealing in welded Ta ampules (700—800 °C, 7—14 d).
ChemInform Abstract: Synthesis of Mn2O3 Homogeneous Core/Hollow‐Shell Structures with Excellent Adsorption Performance.
Authors: Cao Jie , Mao Qinghe , Qian Yitai
Published: August 2012

Mn2O3 homogeneous core/hollow‐shell structures with cube‐shaped and dumbbell‐shaped morphologies are synthesized in high yields from MnCO3 microcubes (obtained from H2O/EtOH solutions of MnSO4, NaHCO3, and (NH4)2SO4, 50 °C, 7 h) or MnCO3 dumbbells (obtained from aqueous solutions of MnCl2, C6H5Na3O7, and NH3, autoclave,160 °C, 2 h).
ChemInform Abstract: Design and Development of Bioinspired Guanine‐Based Organic Catalyst for Asymmetric Catalysis.
Authors: Suez Gal , Bloch Victoria , Nisnevich Gennady , Gandelman Mark
Published: August 2012

A series of 13 guanine‐based chiral catalysts is prepared and tested in the enantioselective Michael addition reaction of malonate (II) to nitrostyrene.
ChemInform Abstract: Simple and Efficient System for the α‐Bromination of a β‐Ketoester by Using N‐Bromosuccinimide in the Presence of Silica‐Supported NaHCO3 as the Heterogeneous Catalyst: An Environmentally Benevolent Approach.
Authors: Rahman Ateeq , Jonnalagadda S. B.
Published: August 2012

Silica‐supported NaHCO3 catalyzes the α‐bromination of carbonyl compounds bearing enolizable α‐positions, e.g. (I), (III) and (V), as well as toluene (VII).
ChemInform Abstract: Mn‐Promoted Aerobic Oxidative C—C Bond Cleavage of Aldehydes with Dioxygen Activation: A Simple Synthetic Approach to Formamides.
Authors: Zhang Chun , Xu Zejun , Shen Tao , Wu Guolin , Zhang Liangren , Jiao Ning
Published: August 2012

Mutagenic active molecules (XIII) and (XV) and the antimalarial active compound (XVII) are easily synthesized under neutral conditions.
ChemInform Abstract: Magnesium‐Catalyzed Hydroboration of Aldehydes and Ketones.
Authors: Arrowsmith Merle , Hadlington Terrance J. , Hill Michael S. , Kociok‐Koehn Gabriele
Published: August 2012

An easily prepared and inexpensive heteroleptic magnesium alkyl complex is presented as an efficient catalyst for the hydroboration of aromatic and aliphatic aldehydes and ketones under mild conditions and at low catalyst loadings.
ChemInform Abstract: Iron Thiolate Complexes: Efficient Catalysts for Coupling Alkenyl Halides with Alkyl Grignard Reagents.
Authors: Cahiez Gerard , Gager Olivier , Buendia Julien , Patinote Cindy
Published: August 2012

The reaction proceeds highly chemo‐ and stereoselective and the yields are slightly better than those obtained with Fe(acac)3.
ChemInform Abstract: One‐Step Synthesis of Highly Functionalized Monofluorinated Cyclopropanes from Electron‐Deficient Alkenes.
Authors: Ivashkin Pavel , Couve‐Bonnaire Samuel , Jubault Philippe , Pannecoucke Xavier
Published: August 2012

Zinc activation (with TmsCl/DMSO in THF) prior to use is a crucial step for the cyclopropanation.
ChemInform Abstract: Simple and Efficient Method for the Preparation of Aryl Azides Using Sonication.
Authors: Telvekar Vikas N. , Sasane Kulbhushan A.
Published: August 2012

Various aryl azides (II) are obtained from aryl compounds (I) in a convenient sonication‐mediated azidation protocol under mild conditions.
ChemInform Abstract: Regioselective Heterohalogenation of 4‐Halo‐anisoles via a Series of Sequential ortho‐Aluminations and Electrophilic Halogenations.
Authors: Conway Ben , Crosbie Elaine , Kennedy Alan R. , Mulvey Robert E. , Robertson Stuart D.
Published: August 2012

The ortho‐alumination of 4‐bromoanisole (I) followed by an electrophilic iodination leads to 2‐iodo‐4‐bromoanisole (II), which is transformed into desired 2‐iodo‐4‐bromo‐6‐chloroanisole (III) by a second ortho‐alumination and a chlorination.
ChemInform Abstract: Vinyl Polymerization versus [1,3] O to C Rearrangements in the Ruthenium‐Catalyzed Reactions of Vinyl Ethers with Hydrosilanes.
Authors: Harada Nari‐aki , Nishikata Takashi , Nagashima Hideo
Published: August 2012

Benzyl vinyl ethers, where the carbocationic species is stabilized by adjacent electron‐rich aromatic groups, induce the [1,3] O to C rearrangement.
ChemInform Abstract: Oxo/Imido Heterometathesis Between N‐Sulfinylamines and Ketones Catalyzed by a Silica‐Supported Molybdenum Imido Complex.
Authors: Zhizhko Pavel A. , Zhizhin Anton A. , Zarubin Dmitry N. , Ustynyuk Nikolai A.
Published: August 2012

Grafting the known molybdenum complex (Ph‐CMe2‐CH2)2Mo(=N‐Mst)2 onto the surface of silica dramatically enhances its catalytic activity in the title heterometathesis reaction.
ChemInform Abstract: Palladium‐Catalyzed Aromatic Azidocarbonylation.
Authors: Miloserdov Fedor M. , Grushin Vladimir V.
Published: August 2012

For the first time, the title reaction is shown to proceed as a remarkably clean and high‐yielding reaction.
ChemInform Abstract: Efficient Approach to Pure Entacapone and Related Compounds.
Authors: Srikanth G. , Ray Uttam Kumar , Rao D. V. N. Srinivas , Gupta P. Badarinadh , Lavanya P. , Islam Aminul
Published: August 2012

A new and efficient route for the synthesis of pure entacapone (V), a known catechol‐O‐methyl transferase inhibitor, through new intermediate (III) is described.
ChemInform Abstract: Nickel‐Catalyzed Heck‐Type Alkenylation of Secondary and Tertiary α‐Carbonyl Alkyl Bromides.
Authors: Liu Chao , Tang Shan , Liu Dong , Yuan Jiwen , Zheng Liwei , Meng Lingkui , Lei Aiwen
Published: August 2012

For the first time the title reaction is described under mild conditions.
ChemInform Abstract: Application of a Novel 1,3‐Diol with a Benzyl Backbone as Chiral Ligand for Asymmetric Oxidation of Sulfides to Sulfoxides.
Authors: Gogoi Paramartha , Kotipalli Trimurthulu , Indukuri Kiran , Bondalapati Somasekhar , Saha Pipas , Saikia Anil K.
Published: August 2012

The method allows the oxidation of prochiral sulfides using a titanium peroxo complex, generated in situ, as the oxidant.
ChemInform Abstract: Highly Efficient Method for the Synthesis of 1,4‐Phenylenedithioureas under Solvent‐ and Catalyst‐Free Conditions Promoted by Microwave Irridiation.
Authors: Zhang Li‐Ping , Shang Xiao‐Bo , Wu Qing‐Fen , Zhang Yang , Li Jian‐Ping
Published: August 2012

1,4‐Phenylene diisothiocyanate reacts with aromatic amines in a nucleophilic addition reaction under solvent‐ and catalyst‐free conditions.
ChemInform Abstract: Highly Effective Activation of Aryl Chlorides for Suzuki Coupling in Aqueous Media Using a Ferrocene‐Based Pd(II)—Diimine Catalyst.
Authors: Hanhan Murat Emre , Martinez‐Manez Ramon , Ros‐Lis Jose Vicente
Published: August 2012

A small amount of the air‐stable catalyst is sufficient enough for the coupling of unactivated chloride substrates.
ChemInform Abstract: Synthesis and Cytotoxicity Evaluation of Biaryl‐Based Chalcones and Their Potential in TNFα‐Induced Nuclear Factor‐ϰB Activation Inhibition.
Authors: Zuo Yinglin , Yu Yi , Wang Shuni , Shao Weiyan , Zhou Binhua , Lin Li , Luo Zhuoyu , Huang Ruogo , Du Jun , Bu Xianzhang
Published: August 2012

A variety of biaryl‐based chalcones are designed, synthesized and evaluated for their inhibitory activities against five cancer cell lines.
ChemInform Abstract: One‐Pot Synthesis of Amidoalkyl Naphthols Using POCl3/Na2B4O7 as a Heterogeneous Catalyst.
Authors: Jafari Hadi , Moghanian Hassan
Published: August 2012

A convenient and efficient multicomponent procedure for the synthesis of 1‐amidoalkyl‐2‐naphthols under solvent‐free conditions is described.
ChemInform Abstract: Copper‐Catalyzed Skeletal Rearrangement of O‐Propargylic Aryloximes into Four‐Membered Cyclic Nitrones — Chirality Transfer and Mechanistic Insight.
Authors: Nakamura Itaru , Kudo Yu , Araki Toshiharu , Zhang Dong , Kwon Eunsang , Terada Masahiro
Published: August 2012

The cyclization process is investigated with respect to regio‐ and E/Z‐selectivity.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of 4‐Oxaspiro[2.4]heptanes via Central Attack of Oxygen Nucleophiles to π‐Allylpalladium Intermediates.
Authors: Shintani Ryo , Ito Tomoaki , Hayashi Tamio
Published: August 2012

Treatment of lactones of type (I) and (V) with aldehydes under conditions A) results in selective formation of 4‐oxaspiro[2.4]heptanes.
ChemInform Abstract: Three‐Component Reactions of Isocyanides, Dialkyl Acetylenedicarboxylates, and trans‐Cinnamoyl Chlorides for the Synthesis of Highly Functionalized 2‐Vinyl Furans.
Authors: Esmaeili Abbas Ali , Zangouei Mahdieh , Hosseinabadi Rahele , Fakhari Ali Reza
Published: August 2012

as synthons for natural products and pharmaceutical substances
ChemInform Abstract: Ultrasound‐Assisted Bismuth Nitrate‐Induced Green Synthesis of Novel Pyrrole Derivatives and Their Biological Evaluation as Anticancer Agents.
Authors: Bandyopadhyay Debasish , Mukherjee Sanghamitra , Granados Jose C. , Short John D. , Banik Bimal K.
Published: August 2012

Two compounds, compounds (IIId) and (IIIe), show good cytotoxicity against some cancer cell lines and exhibit cytotoxic specificity against liver cancer cell lines in vitro when compared with cultured primary hepatocytes.
ChemInform Abstract: A Synthetic Approach to Diverse 3‐Acyltetramic Acids via O‐ to C‐Acyl Rearrangement and Application to the Total Synthesis of Penicillenol Series.
Authors: Sengoku Tetsuya , Nagae Yuta , Ujihara Yasuaki , Takahashi Masaki , Yoda Hidemi
Published: August 2012

The efficient route to various biologically important 3‐acyltetramic acids can be applied to prepare penicillenol A2 (XIII).
ChemInform Abstract: Asymmetric Allylic Alkylation of Pyrroles and 4,7‐Dihydroindoles with Alkene—Phosphine Ligands.
Authors: Liu Yilin , Cao Ziping , Du Haifeng
Published: August 2012

Under conditions A), isomerization of cis‐alkenes to trans isomers is observed.
ChemInform Abstract: A Heterotrimetallic Pd—Sm—Pd Complex for Asymmetric Friedel—Crafts Alkylations of Pyrroles with Nitroalkenes.
Authors: Zhang Guoqi
Published: August 2012

A novel catalyst, which can be readily prepared in situ, is effective in the title reaction.
ChemInform Abstract: A N‐Heterocyclic Carbene (NHC) Platinum Complex as Pre‐Catalyst for the Intramolecular Hydroamination of Olefins with Secondary Alkylamines and Oxidative Amination of ω‐Alkenic Amines.
Authors: Zhang Rui , Xu Qin , Mei Liang‐yong , Li Sheng‐ke , Shi Min
Published: August 2012

The novel complex (NHCPT) along with AgBF4 is a highly efficient system for the title reaction.
ChemInform Abstract: Highly Reactive meso‐Like Positions of Dipyrihexaphyrin.
Authors: Setsune Jun‐ichiro , Yamato Kyohei
Published: August 2012

The meso‐like positions in the pyridine‐containing porphyrin analogue (I), structurally related to amethyrin, are highly reactive towards addition of alcohols, amines, or cyanide.
ChemInform Abstract: One‐Pot, Pseudo Five‐Component Synthesis of Spirooxindole Derivatives Containing Fused 1,4‐Dihydropyridines in Water.
Authors: Alizadeh Abdolali , Mikaeili Azadeh , Firuzyar Tahereh
Published: August 2012

The reaction of nitroethylene (III) with ammonia generates a ketene diaminal intermediate which reacts with a Knoevenagel product, formed in situ from isatins and 1,3‐dicarbonyl compounds, to yield the title compounds.
ChemInform Abstract: Synthesis of 6H‐Isoindolo[2,1‐a]indol‐6‐ones Through a Sequential Copper‐Catalyzed C—N Coupling and Palladium‐Catalyzed C—H Activation Reaction.
Authors: He Hua‐Feng , Dong Sheng , Chen Yi , Yang Yang , Le Yueqin , Bao Weiliang
Published: August 2012

The one‐pot reaction comprises a copper‐catalyzed C—N coupling cyclization and a palladium‐catalyzed C—H activation course.
ChemInform Abstract: Facile, Novel Two‐Step Syntheses of Benzimidazoles, Bis‐benzimidazoles, and Bis‐benzimidazole‐dihydroquinoxalines.
Authors: Xu Zhigang , Shaw Arthur Y. , Dietrich Justin , Cappelli Alexandra P. , Nichol Gary , Hulme Christopher
Published: August 2012

A series of title compounds is synthesized by a strategy which involves Ugi four‐component condensation of the isonitrile (I) followed by TFA‐mediated deprotection and cyclization.
ChemInform Abstract: Synthesis of Benzothiazoles Through Copper‐Catalyzed One‐Pot Three‐Component Reactions with Use of Sodium Hydrosulfide as a Sulfur Surrogate.
Authors: Park Namjin , Heo Yumi , Kumar Manian Rajesh , Kim Yong , Song Kwang Ho , Lee Sunwoo
Published: August 2012

A variety of 2‐iodoanilines and aromatic/heteroaromatic aldehydes undergo the title reaction.
ChemInform Abstract: Alkyne—Azide Cycloaddition Catalyzed by Fe—Cu Nanoparticles.
Authors: Garcia‐Munoz Angel , Gonzalez Jaime , Trujillo‐Reyes Jessica , Morales‐Luckie Raul A. , Sanchez‐Mendieta Victor , Gonzalez Carlos , Fuentes Aydee , Cuevas‐Yanez Erick
Published: August 2012

Paramagnetic Fe—Cu nanoparticles are used to catalyze typical azide—alkyne cycloadditions.
ChemInform Abstract: New Triazole Derivatives as Antifungal Agents: Synthesis via Click Reaction, in vitro Evaluation and Molecular Docking Studies.
Authors: Zou Yan , Zhao Qingjie , Liao Jun , Hu Honggang , Yu Shichong , Chai Xiaoyun , Xu Mingjuan , Wu Qiuye
Published: August 2012

A series of fluconazole analogues (I) is designed and synthesized using a click chemistry approach.
ChemInform Abstract: Design, Synthesis, Computational and Biological Evaluation of Some New Hydrazino Derivatives of DHA (III) and Pyrazopyrazoles (IV).
Authors: Kumar Ajay , Lohan Poonam , Aneja Deepak K. , Gupta Girish Kumar , Kaushik Dhirender , Prakash Om
Published: August 2012

New hydrazino derivatives of dehydroacetic acid (DHA) and their cyclic analogues (IV) are synthesized starting from 3‐acetyl‐4‐chloropyranone (I).
ChemInform Abstract: Facile Synthesis of 4‐Substituted 3,4‐Dihydrocoumarins via an Organocatalytic Double Decarboxylation Process.
Authors: Peng Shiyong , Wang Lei , Guo Haibing , Sun Shaofa , Wang Jian
Published: August 2012

The first organocatalytic double decarboxylation strategy for an efficient and convenient synthesis of the title compounds is presented.
ChemInform Abstract: Direct C—H Cross‐Coupling Approach to Heteroaryl Coumarins.
Authors: Min Minsik , Kim Bomi , Hong Sungwoo
Published: August 2012

The spectroscopic properties of all synthesized compounds are investigated in CH2Cl2.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric 6‐endo Cyclization of Dienamides with Substituent‐Driven Activation.
Authors: Tsuchikawa Hiroshi , Maekawa Yuya , Katsumura Shigeo
Published: August 2012

The activation by the tosyl and the C‐3 ester function is essential for the cyclization.
ChemInform Abstract: Deprotonative Metalation of Aromatic Compounds Using Mixed Lithium—Iron Combinations.
Authors: Nagaradja Elisabeth , Chevallier Floris , Roisnel Thierry , Jouikov Viatcheslav , Mongin Florence
Published: August 2012

The electrophilic trapping with LiFe(TMP)3 affords mostly the desired product together with the 2,2‐dimer of the substrate.
ChemInform Abstract: Dihydropyridones: Catalytic Asymmetric Synthesis, N‐ to C‐Sulfonyl Transfer, and Derivatizations.
Authors: Simal Carmen , Lebl Tomas , Slawin Alexandra M. Z. , Smith Andrew D.
Published: August 2012

A scalable addition reaction and the first example of a N‐ to C‐sulfonyl photoisomerization reaction of a dihydropyridone, cf.
ChemInform Abstract: A Concise Synthesis of Tetrahydroisoquinoline‐1‐carboxylic Acids Using a Petasis Reaction and Pomeranz—Fritsch—Bobbitt Cyclization Sequence.
Authors: Chrzanowska Maria , Grajewska Agnieszka , Meissner Zofia , Rozwadowska Maria , Wiatrowska Iwona
Published: August 2012

The sequence affords the target compounds in only 2 steps.
ChemInform Abstract: A Concise Synthesis of 6H‐Indolo[2,3‐b]quinolines: Formal Synthesis of Neocryptolepine.
Authors: Kadam Hari K. , Parvatkar Prakash T. , Tilve Santosh G.
Published: August 2012

The convenient two‐step approach to indoloquinolines (IV) proceeds via C‐3 alkylation of indoles (I) followed by a one‐pot reduction—cyclization—aromatization sequence.
ChemInform Abstract: Bis(imino)pyridine (BIMP) Fe(II) Catalyzes One‐Pot Green Condensation of Resorcinol, Malononitrile, Aromatic Aldehydes and Cyclohexanone.
Authors: Damavandi Saman , Sandaroos Reza
Published: August 2012

Title reaction proceeds smoothly under ultrasound irradiation and under solvent‐free conditions to give the tetracyclic pyrano[2,3‐b]pyridines (V) with excellent regioselectivity.
ChemInform Abstract: Discovery of S‐444823, a Potent CB1/CB2 Dual Agonist as an Antipruritic Agent.
Authors: Odan Masahide , et al. et al.
Published: August 2012

The optimization of a series of 3‐carbamoyl‐2‐pyridone derivatives (I) as CB agonists is reported.
ChemInform Abstract: Prins Cyclization of Styrenes or Acetophenone Catalyzed by DBSA in Water.
Authors: Zhang Juan , Hua Lin , Li Feifei , Wu Xuefen , Tian Shengzhin , Yang Jing
Published: August 2012

Dodecylbenzenesulfonic acid (DBSA) is shown to be an efficient catalyst for the Prins cyclization of styrene derivatives with formaldehyde or acetaldehyde in water to give a variety of aryl‐substituted dioxane derivatives.
ChemInform Abstract: Efficient Synthesis of Flupirtine Analogues Derived from Pyrimidine.
Authors: Hansen Finn K. , Geffken Detlef
Published: August 2012

N‐5‐Acylated pyrimidinetriamines (V),(VII), and (IX) are prepared as analogues of the analgesic flupirtine.