bluuebunny/crossref_metadata_2025 huggingface dataset:
Table 2 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Comparison of publication rates by SEP category
Table S5 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S5 shows AEs with Attribution Possible, Probable or Definite to Treatment (HDVIC or Placebo) listed by types and grades
Supplemental Table S6 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Comparison of publication and reporting between the overall dataset and the sensitivity analysis restricting SEPs to only those from both the protocol and ClinicalTrials.Gov, from trials with multiple protocols available.
Table S2 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S2 shows Association of HDIVC Treatment with PSA Response Adjusting for Prior Docetaxel Exposure
Supplemental Table S1 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Comparison of publication rates by SEP detection method.
Supplemental Figure S1 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Structural casual model of the relationship between the number of SEPs, confounding variables, and the percent of SEPs published. Orange represents the exposure of interest (number of SEPs), yellow represents the outcome of interest (percent of SEPs published), and the red arrow indicates the causal path. Green circles indicate confounders, blue circles indicate non-confounding ancestors of the exposure and outcome. Black arrows represent biasing pathway.
Table S11 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S11 shows FACT-P Change (on Study Minus Baseline) Scores
Table 2 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

PSA response rate
Supplementary: Trial Protocol from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Trial Protocol shows the details of the study
Data from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Abstract
High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking. We evaluated the clinical benefit of combining HDIVC with docetaxel in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). In this double-blind, placebo-controlled phase II trial, 47 patients were randomized 2:1 to receive docetaxel (75 mg/m2 i.v.) with either HDIVC (1 g/kg) or placebo. Coprimary endpoints were PSA50 response and adverse event rates. Secondary endpoints included overall survival, radiographic progression-free survival, and quality of life measured using the Functional Assessment of Cancer Therapy-Prostate instrument. Correlative analyses included pharmacokinetics and oxidative stress markers. Eighty-nine percent of patients previously had three or more lines of therapy. The PSA50 response rate was 41% in the HDIVC group and 33% in the placebo group (P = 0.44), with comparable adverse event rates in both groups. There were no significant differences in Functional Assessment of Cancer Therapy-Prostate scores. The median radiographic progression-free survival was not significantly different between the HDIVC and placebo groups, with durations of 10.1 and 10.0 months (HR, 1.35; 95% confidence interval, 0.66–2.75; P = 0.40), respectively. The median overall survival was 15.2 months in the HDIVC group and 29.5 months in the placebo group (HR, 1.98; 95% confidence interval, 0.85–4.58; P = 0.11). HDIVC did not decrease F2-isoprostanes, indicators of oxidative stress. The study was suspended after prespecified interim analysis indicated futility in achieving primary endpoints. In this patient population, combining HDIVC with docetaxel did not improve PSA response, toxicity, or other clinical outcomes compared with docetaxel alone. Findings do not support the routine use of HDIVC in mCRPC treatment outside of clinical trials.
Significance:
This is the first randomized, placebo-controlled, double-blind trial to evaluate HDIVC in cancer treatment. The addition of HDIVC to docetaxel in patients with mCRPC does not improve PSA response, toxicity, or other clinical outcomes compared with docetaxel alone. The routine use of HDIVC in mCRPC treatment is not supported outside of clinical trials.
Data from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Abstract
Secondary endpoints (SEP) provide crucial information in the interpretation of clinical trials, but their features are not yet well understood. Thus, we sought to empirically characterize the scope and publication rate of SEPs among late-phase oncology trials. We assessed SEPs for each randomized, published phase III oncology trial across all publications and ClinicalTrials.gov, performing logistic regressions to evaluate associations between trial characteristics and SEP publication rates. After screening, a total of 280 trials enrolling 244,576 patients and containing 2,562 SEPs met the inclusion criteria. Only 22% of trials (62/280) listed all SEPs consistently between ClinicalTrials.gov and the trial protocol. The absolute number of SEPs per trial increased over time, and trials sponsored by industry had a greater number of SEPs (median 9 vs. 5 SEPs per trial; P < 0.0001). In total, 69% of SEPs (1,770/2,562) were published. The publication rate significantly varied by SEP category [X2 (5, N = 2,562) = 245.86; P < 0.001]. SEPs that place the most burden on patients, such as patient-reported outcomes and translational correlatives, were published at 63% (246/393) and 44% (39/88), respectively. Trials with more SEPs were associated with lower overall SEP publication rates. Overall, our findings are that SEP publication rates in late-phase oncology trials are highly variable based on the type of SEP. To avoid undue burden on patients and promote transparency of findings, trialists should weigh the biological and clinical relevance of each SEP together with its feasibility at the time of trial design.
Significance:
In this investigation, we characterized the utilization and publication rates of SEPs among late-phase oncology trials. Our results draw attention to the proliferation of SEPs in recent years. Although overall publication rates were high, underpublication was detected among endpoints that may increase patient burden (such as translational correlatives and patient-reported outcomes).
Novos gonyleptidas brasileiros
Authors: Piza Junior S. de Toledo
Published: August 2024

.
Desigualdades raciais para além do paradigma
Authors: França Danilo
Published: August 2024

The so-called “paradigm of racial  inequalities”, inaugurated by Carlos Hasenbalg, answered decisive  questions about the permanence of disparities between blacks and whites in Brazil and guided new agendas, research designs and forms of  analysis of racial inequalities. This article builds some critical notes on  the way in which racial inequalities  are thematized based on this paradigm, especially the focus on the market as a sphere of observation, and points out the potential for retaking this research object by the contemporary sociology of racial relations, renewed by perspective of intersectionalities and the emergence of new themes.
“Defendendo a paz social”: entre a naturalização e o racismo em decisões de decretação de prisão preventiva.
Authors: Marques Luiz Henrique Gamboa , Lourenço Luiz Cláudio
Published: August 2024

This study aimed to analyze the arguments mobilized by judges to justify the issuance of preventive detention orders and to observe the existence of a relationship between these arguments and class and race factors. The methodology used was the documentary analysis of  interlocutory decisions converting flagrant arrests into preventive detentions, referring to charges of theft and robbery that occurred between 2015 and 2018 in the metropolitan region of Salvador, Brazil. A total of 322 interlocutory decisions to decree preventive  detention were analyzed, retrieved from the case files of Salvador  Prison/BA, a unit for temporary detainees. At the end of the research, it was concluded that, among the justifications in force in Article 312 of the Code of Criminal Procedure, 100% of the decisions analyzed were based on the category of guaranteeing  public order, understood as social harmony offended by the  dangerousness of the prisoner. This dangerousness is expressed by the concepts of criminal recidivism and modus operandi. It was also concluded that these arguments reproduce class and race stereotypes, since they use mechanisms to naturalize the group most affected by the net of the criminal justice system (young black men), depriving them of the enjoyment of citizenship and  protection of fundamental rights.
As deputadas federais do Partido Liberal (2023-27): um estudo sobre as ameaças ao feminismo e à democracia
Authors: Rodrigues Iurca Lazzariny dos Santos , Jesus Clécia Trindade Almeida de , Ferreira Maria Inês Caetano
Published: August 2024

Este artículo presenta un estudio sobre el desempeño de las diputadas federales del Partido Liberal en ejercicio de la 57ª legislatura (2023-27) en el actual proceso de enfrentamiento a los principios del feminismo, en el objetivo de comprender cómo la defensa de las ideas antifeministas e antidemocráticas se llevan a cabo ideales democráticos por parte de estas legisladores, vocalizadoras de valores extremistas. Algunas corrientes académicas reflexionan sobre los vínculos entre el avance del extremismo en la política con la consolidación del neoliberalismo con los que comparte esta investigación. La metodología adoptada fue un relevamiento exhaustivo de artículos de prensa sobre las diputadas, a partir de los perfiles elaborados se crearon categorías que informan las singularidades y diferencias entre ellas. Los resultados muestran que los valores y acciones de estas legisladoras amenazan los derechos conquistados por los movimientos feministas e, incluso, la democracia.
Para acolhimento da fé: breve panorama histórico sobre a construção da Igreja Matriz de Santo Amaro, em Brumal – Minas Gerais
Authors: Pedrosa Aziz José de Oliveira
Published: August 2024

Durante o século XVIII, a exploração mineral em Minas Gerais suscitou a construção de espaços destinados a suprir as necessidades espirituais da população. Nessa perspectiva, foi elevada a igreja Matriz de Santo Amaro, localizada no distrito mineiro de Brumal, cujo processo construtivo ilustra fração do panorama da arquitetura sacra no território da América portuguesa. Nesse sentido, este artigo tem como objetivo examinar, por intermédio de documentação primária, a história da igreja Matriz de Santo Amaro, focalizando-se o processo construtivo, os materiais e a técnicas utilizadas para sua construção, bem como as soluções arquitetônicas manuseadas diante das práticas correntes nos canteiros de obra da primeira metade dos anos setecentos, posto ser evidente, na região, a repetição do uso de partidos similares e programas arquitetônicos para delinear a organização espacial e definir a volumetria do conjunto da edificação.
Acompanhamento por estudantes de idosos em situação de distanciamento social devido a pandemia de Covid 19: experiência do grupo tutorial Pet Magaldi
Authors: Almeida Maria Helena Morgani de , Zilboviclus Celso , Silva Helena Teofilo Ferreira da , Gomes Larissa Pagani , Bastos Mariana Menezes , Silva Matheus Moser da , Oliveira Raquel Ribeiro de , Dieb Iara , Coelho Lucia Moreira
Published: August 2024

Resumo do Congresso de Graduação da USP 2021.
O lugar institucional de formação de professores para o ensino superior na Universidade de São Paulo
Authors: Rivas Noeli Prestes Padilha , Monti Aline Cristina Gimenes
Published: August 2024

Resumo do Congresso de Graduação da USP 2021.
Conexão dos alunos ao exercício da cidadania através do trabalho com ODS na disciplina de educação ambiental
Authors: Vicente Luene Pessoa , Lazarin Marilia , Sevilha Gabriel , Oliveira Vitor Caetano , Fernandez Fernanda da Rocha Brando
Published: August 2024

Resumo do Congresso de Graduação USP 2021.
A implantação de um laboratório de aprendizagem digital como recurso indutor para o uso de tecnologias digitais no ensino de graduação
Authors: Nardocci Adelaide Cassia , Ito Erica Sayuri , Almeida Ingrid Mags Carvalho de , Almeida Daniely Soares Lino , Bógus Cláudia Maria
Published: August 2024

Resumo do Congresso de Graduação USP 2021.
A experiência da disciplina EAD0720 vinculada ao CAEG "aprendendo e transformando: ensino de graduação vinculado à extensão universitária interdisciplinar e empreendedora
Authors: Rodrigues Ana Carolina de Aguiar
Published: August 2024

Resumo do Congresso de Graduação USP 2021.
Criando Startups a Partir de Aprendizagem Baseada em Projetos na Disciplina “ZMV1386 - Biologia Molecular: Desenvolvendo Projetos”
Authors: Nunes Alanne , Fukumasu Heidge
Published: August 2024

Previous research has highlighted the necessity of enhancing the teaching-learning process, given the demand for a workforce that is proficient in formulating problem-solving strategies. The course in which the current didactic-pedagogical project was applied follows a project-based learning (PBL) approach, wherein students identify a problem within their area of ​​interest and formulate strategies to address it. With the goal of adapting this approach to real-world market conditions, the present proposal was conceived, focusing on simulating the establishment of startups based on developed projects. To achieve this, students initiate the activity by delineating the central problem that the company aims to solve, along with assigning a name to the startup, followed by the allocation of roles, strategic planning and resource identification, a recap of activities based on molecular technologies, projection of tasks for the upcoming semester, and specification of expected outcomes and limitations. In the last class of the course, projects completed over the semester were presented. Remarkable student engagement was observed in the startup simulation, encompassing the creation of websites, slogans, and logos to captivate the end consumer of the product or service. Additionally, an electronic survey was conducted to understand the students’ opinions, and the outcomes served to validate the success of the proposal. These findings further support the idea that active teaching methodologies have the potential to enhance the development of student skills toward problem solving within their future areas of activity.
Pré-Cálculo: Um Curso Preparatório Para Ingressantes da ESALQ/USP
Authors: Souza Carolina Rodrigues , Zilio Jéssica Carolina , Oliveira Allison Queiroz de , Savian Taciana Villela , Silva Marcelo Andrade da
Published: August 2024

Cálculo é uma disciplina fundamental para diversos cursos de nível superior, uma vez que promove a construção de um raciocínio lógico e matemático essencial para a resolução de problemas práticos e tomadas de decisão. Apesar da sua importância, uma parcela considerável dos alunos não obtém máximo aproveitamento das aulas, devido sobretudo à falta de conhecimento prévio em Matemática e à dificuldade em assimilar conceitos abstratos.  A preocupação com relação ao mau desempenho dos graduandos na disciplina de Cálculo vai além da questão curricular, uma vez que o déficit de aprendizagem desses conceitos pode impactar no rendimento de disciplinas posteriores e até na vida profissional dos indivíduos. Diante desse impasse, foi criado em 2018 o Curso Pré-Cálculo, oferecido pelo Departamento de Ciências Exatas aos alunos ingressantes da ESALQ/USP. Este trabalho descreve o surgimento do curso, seu formato atual e os principais resultados obtidos ao longo do seu oferecimento. O curso passou por melhorias a cada nova edição, incluindo uma reestruturação da carga horária e a criação de uma apostila, baseada na demanda dos participantes. Graças ao empenho e dedicação dos professores e alunos da pós-graduação, tem sido observado nas últimas edições uma evolução positiva com relação à aprovação dos alunos na disciplina de Cálculo, bem como na avaliação do curso pelos próprios participantes.
Coronary Atherosclerotic Plaque Burden Assessment by Computed Tomography and Its Clinical Implications
Authors: Vatsa Nishant , Faaborg-Andersen Christian , Dong Tiffany , Blaha Michael J. , Shaw Leslee J. , Quintana Raymundo A.
Published: August 2024

Recent studies have demonstrated that coronary plaque burden carries greater prognostic value in predicting adverse atherosclerotic cardiovascular disease outcomes than myocardial ischemia, thereby challenging the existing paradigm. Advances in plaque quantification through both noncontrast and contrast-enhanced computed tomography (CT) methods have led to earlier and more cost-effective detection of coronary disease compared with traditional stress testing. The 2 principal techniques of noninvasive coronary plaque quantification assessment are coronary artery calcium scoring by noncontrast CT and coronary CT angiography, both of which correlate with disease burden on invasive angiography. Plaque quantification from these imaging modalities has shown utility in risk stratification and prognostication of adverse cardiovascular events, leading to increased incorporation into clinical practice guidelines and preventive care pathways. Furthermore, due to their expanding clinical value, emerging technologies such as artificial intelligence are being integrated into plaque quantification platforms, placing more advanced measures of plaque burden at the forefront of coronary plaque evaluation. In this review, we summarize recent clinical data on coronary artery calcium scoring and coronary CT angiography plaque quantification in the evaluation of adverse atherosclerotic cardiovascular disease in patients with and without chest pain, highlight how these methods compare to invasive quantification approaches, and directly compare the performance characteristics of coronary artery calcium scoring and coronary CT angiography.
Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study
Authors: Villar-Calle Pablo , Kochav Jonathan D. , Vadaketh Krista , Chiu Caitlin , Tak Katherine , Agoglia Hannah , Liberman Nicole , Nguyen Kenny L. , Vizcarra-Tellez Abdier , Wu Alan , RoyChoudhury Arindam , Khalique Omar K. , Judd Robert M. , Kim Raymond J. , Shah Dipan J. , Heitner John F. , Farzaneh-Far Afshin , Shenoy Chetan , Owyang Clark G. , Mukherjee Monica , Horn Evelyn M. , Weinsaft Jonathan W. , Kim Jiwon
Published: August 2024

BACKGROUND:

Right ventricular (RV) dysfunction is known to impact prognosis, but its determinants in coronary artery disease are poorly understood. Stress cardiac magnetic resonance (CMR) has been used to assess ischemia and infarction in relation to the left ventricle (LV); the impact of myocardial tissue properties on RV function is unknown.

METHODS:

Vasodilator stress CMR was performed in patients with known coronary artery disease at 7 sites between May 2005 and October 2018. Myocardial infarction was identified on late gadolinium enhancement-CMR, and infarct transmurality was graded on a per-segment basis. Ischemia was assessed on stress CMR based on first-pass perfusion and localized by using segment partitions corresponding to cine and late gadolinium enhancement analyses. RV function was evaluated by CMR-feature tracking for primary analysis with a global longitudinal strain threshold of 20% used to define impaired RV strain (RV
IS
); secondary functional analysis via RV ejection fraction was also performed.

RESULTS:

A total of 2604 patients were studied, among whom RV
IS
was present in 461 patients (18%). The presence and magnitude of RV
IS
were strongly associated with LV dysfunction, irrespective of whether measured by LV ejection fraction or wall motion score (
P
<0.001 for all). Regarding tissue substrate, regions of ischemic and dysfunctional myocardium (ie, hibernating myocardium) and infarct size were each independently associated with RV
IS
(both
P
<0.001). During follow-up (median, 4.62 [interquartile range, 2.15–7.67] years), 555 deaths (21%) occurred. Kaplan-Meier analysis for patients stratified by presence and magnitude of RV dysfunction by global longitudinal strain and RV ejection fraction each demonstrated strong prognostic utility for all-cause mortality (
P
<0.001). RV
IS
conferred increased mortality risk (hazard ratio, 1.35 [95% CI, 1.11–1.66];
P
=0.003) even after controlling for LV function, infarction, and ischemia.

CONCLUSIONS:

RV
IS
in patients with known coronary artery disease is associated with potentially reversible LV processes, including LV functional impairment due to ischemic and predominantly viable myocardium, which confers increased mortality risk independent of LV function and tissue substrate.
Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study
Authors: Jiang Xiaqing , Schreiner Pamela J. , Gunderson Erica P. , Yaffe Kristine
Published: August 2024

BACKGROUND:

To understand the role of hypertensive disorders of pregnancy (HDP), including preeclampsia and gestational hypertension (GH), in brain health earlier in life, we investigated the association of HDP with midlife cognition and brain health.

METHODS:

We studied a prospective cohort of women, baseline age 18 to 30 years, who were assessed at study years 25 and 30 with a cognitive battery and a subset with brain magnetic resonance imaging. A history of HDP was defined based on self-report. We conducted linear regression to assess the association of a history of preeclampsia, GH, or no HDP with cognition and brain magnetic resonance imaging white matter hyperintensities.

RESULTS:

Among 1441 women (mean age, 55.2±3.6 years), 202 reported preeclampsia and 112 reported GH. GH was associated with worse cognitive performance: global cognition (mean score, 23.2 versus 24.0;
P
=0.018), processing speed (67.5 versus 71.3;
P
=0.01), verbal fluency (29.5 versus 31.1;
P
=0.033), and a trend for executive function (24.3 versus 22.6;
P
=0.09), after multivariable adjustment. GH was associated with a greater 5-year decline in processing speed (mean change, −4.9 versus −2.7;
P
=0.049) and executive function (−1.7 versus 0.3;
P
=0.047); preeclampsia was associated with a greater 5-year decline on delayed verbal memory (−0.3 versus 0.1;
P
=0.041). GH and preeclampsia were associated with greater white matter hyperintensities in the parietal and frontal lobes, respectively.

CONCLUSIONS:

GH and preeclampsia are associated with cognition and white matter hyperintensities during midlife, with differences in cognitive domains and brain lobes. Women with HDP may need to be closely monitored for adverse brain outcomes starting in midlife.
Do the New Brazilian Agreements on Cooperation and Facilitation of Investment Promote Outward Foreign Direct Investment?
Authors: Bellak Christian , Leibrecht Markus
Published: August 2024

Brazil has recently adopted a novel approach in investment protection, the Agreements on Cooperation and Facilitation of Investment (ACFIs) which aim inter alia at promoting Brazil’s rising outward FDI. Motivated by claims that ACFIs will not achieve this goal – while otherwise tying the hands of policy makers – we use data over the years 2001 to 2022 and apply a Synthetic Control approach to study whether outward Foreign Direct Investment Stock of Brazil in Mexico is spurred by the ratification of the Mexico–Brazil ACFI. The concerns about ACFIs cannot be dismissed as our evidence shows that the ACFI does not promote outward foreign direct investment (FDI), at least for the post-treatment years used in our analysis. The absence of an impact is most likely driven by the omission of substantive provisions and, most notably, of Investor-State Dispute Settlement, which would address the hold-up problem in international investment.
Use of rice by-products for production of the Tenebrio molitor larvae: emphasis on the fatty acid profile
Authors: Chamorro D.P. , Dias K.C. , Oliveira L.F.S. , Cordeiro M.W.S. , Wagner R. , Kuradomi R.Y. , Pedron F.A. , Ferrigolo F.R.G. , Pretto A. , Lanes C.F.C.
Published: August 2024

The objectives of this study were to assess the ability of Tenebrio molitor larvae to biotransform by-products from rice processing enriched with 1% flaxseed oil into high-nutritional value food and to obtain oil from T. molitor larvae with a fatty acid profile suitable for future application in animal nutrition. Larvae of T. molitor were cultured on seven experimental diets, including four diets composed of rice processing by-products enriched with 1% flaxseed oil (rice husk, rice cleaning residue, whole rice bran, and defatted rice bran), and three control diets (chicken feed, wheat bran in combination with yeast (in a 9:1 ratio) with the addition of 1% flaxseed oil, and wheat bran in combination with yeast (in a 9:1 ratio) without flaxseed oil). The addition of 1% flaxseed oil aimed to improve the larvae’s fatty acid profile. Growth and larval survival were assessed during the experimental period. The larvae were analyzed for dry matter, ash, protein, fat levels, and fatty acid profiles. Larvae fed diets containing wheat bran with oil (111.9 ± 5.2 mg) and wheat bran without oil (111.6 ± 1.9 mg) exhibited significantly higher final weights than the rest of the dietary treatments, followed by larvae fed diets composed of rice cleaning residue (75.8 ± 2.2 mg) and chicken feed (67.8 ± 7.0 mg). The remaining treatments showed significantly lower weights. Survival rates were similar among treatments, being equal to or greater than 90%. Protein content ranged from 39.3% to 49.1%, while lipid levels varied from 23.3% to 39.4%. The fatty acid profile differed significantly among treatments. Linoleic acid (C18:2n-6) was the predominant polyunsaturated fatty acid (PUFA), with the highest concentration observed in larvae fed chicken feed. Higher levels of polyunsaturated fatty acids (PUFAs) were found in larvae raised on whole rice bran. The highest omega-6 content was found in the larvae reared with chicken feed (24.1%), while the highest omega-3 content was found in the treatment with whole rice bran (6.1%). The omega-6/omega-3 ratio varied significantly among the treatments, reaching 42.9 in the treatment with rice cleaning residue, while in the whole rice bran treatment, the ratio was 3.5. Moreover, in wheat bran treatments, the addition of 1% flaxseed oil reduced the omega 6/omega-3 ratio from 29.1 to 8.9. The growth results of the current study demonstrate that among the tested rice by-products, the best outcomes were obtained with rice cleaning residue. However, the most favorable fatty acid profile for future application in animal nutrition was achieved with whole rice bran enriched with 1% flaxseed oil.
Tech Competency and the Pink pc: Illuminating the iMac G3 and pc Builds
Authors: Harkin Stephanie
Published: August 2024

Where women were once historically at the forefront of computer programming, contemporary tech culture erases their participation. Today, however, tech-competency is showcased as feminine in online Pink pc build videos, which contest dominant narratives that place tech culture adjacent to geek masculinity. Before young people were building their own Pink pc’s, Apple’s G3 series represented an earlier articulation of feminine computer design. Apple’s rounded, colourful personal computer became an unconventional marker of femininity. Pink pc s challenge technology’s prevalent masculine-coding. Their hyperfeminine designs reflect possible agentic identity expression and resistance to hegemonic masculine taste values. Yet, the Pink pc also surfaces in corporate and post-feminist contexts and cultures, typically restricted by economic mobility. This article explores these contradictions through the Pink pc, from Apple’s G3 to Pink pc builds today, developing understandings towards feminist science and technology studies, invisible gaming cultures, and Critical Femininities.
Development of a Two-Step EOF Statistical Postprocessing Algorithm to Identify Patterns of Systematic Error and Variance within GEFSv12 Reforecasts
Authors: Stikeleather William D. , Roundy Paul E.
Published: August 2024

Analysis of seasonally varying signals of model error biases, as well as the diagnosis of space–time patterns of synoptic error, here is accomplished through the development of a statistical postprocessing algorithm based on time-extended empirical orthogonal functions (EEOFs) built on patterns of variance. This work analyzes GEFSv12 200-hPa geopotential height (Z200) model error against ERA5 reanalysis data. The mean-square error variance between GEFSv12 reforecast and ERA5 grows rapidly after day 7 of a forecast and continues to increase through the end of the 16-day forecast period. At lead time 16, the largest variance occurs in mid- to high-latitude oceanic storm tracks. Variance is highest during hemispheric winter when baroclinic energy is abundant. The seasonal cycle of error shows largest anomalies in the high latitudes during hemispheric winter. After running the titular two-step, space–time EEOF algorithm, a standardized spatial eigenspectrum shows that eigenvalues increase at longer lead times after decreasing in the medium range, demonstrating that the algorithm extracts large-scale signals of systematic error in the long range. Leading wintertime space–time eigenmode pairs include high-latitude blocking structures and Rossby wave trains. Results suggest that the large-scale systematic errors in GEFSv12 Z200 initiate in part from inaccurate representations of phase speeds of atmospheric waves in the polar jet.
Determining if Admission Thromboelastography can Predict the Development of Late Resolving Multiple Organ Failure in Trauma Patients
Authors: Smith Ross P. , Dwyer Lauren K. , O’Dell Jacob C. , McCoy Christopher C. , Guidry Christopher A. , Winfield Robert A.
Published: August 2024

Background

Normal coagulation TEG values on admission negatively correlate with overall risk of multiple organ failure, but less is known about association between coagulation and late-resolving multiple organ failure (LRMOF) risk. Here, the relationship between TEG parameters and development of LRMOF was investigated.

Methods

We conducted a retrospective assessment of patients at high postinjury multiple organ failure risk at our center. The primary outcome was LRMOF.

Results

Analysis included 742 patients. Demographics were 76% male, mean age of 41, mean ISS of 23, 34% hypercoagulability, and 16% developed LRMOF. Patients with normal admission TEG developed LRMOF at significantly lower unadjusted rates than patients with coagulation disturbances (9 vs 16%-19%, P = 0.029); however, multivariable logistic regression demonstrated that neither coagulation profile nor individual admission TEG parameters showed association with LRMOF.

Conclusions

In this series, we found no significant relationship between coagulation status and LRMOF development.
Systematic Literature Review of the Presentation and Management of Pediatric Relapsing Polychondritis
Authors: Montero Mackenzie L. , Panda Roshan M. , Palacios Victoria J. , Solis Roberto N. , Levi Jessica R.
Published: August 2024

Introduction:

Pediatric Relapsing Polychondritis (RP) is a rare autoimmune disorder that causes inflammation and damage to cartilage in children. Common symptoms include pain, swelling and deformities in the ears, nose, trachea, joints, and eyes. The lack of research on the pediatric population necessitates further evaluation of the literature on pediatric RP to summarize existing patterns in presentation, management, and treatment.

Methods:

A systematic review was conducted on PubMed and Embase from 1947 to April 2023 on RP in patients under 21 years old abiding by the 2020 PRISMA checklist. Only patient presentations meeting McAdam criteria for RP and including information on management were included.

Results:

From the 304 initial studies, 54 studies were included for final analysis with a total of 68 patients, who were predominantly female (65%). With a median diagnostic delay of 1 year, the mean age of onset was 12 years old. The most common symptoms on presentation included bilateral auricular chondritis (69%), nasal cartilage inflammation (62%), and respiratory tract chondritis (63%). The most commonly reported information in the literature for the initial workup usually included CT/MRI (72%), bronchoscopy (57%), biopsy (51%), and labs (88%), which most commonly displayed elevated ESR (59%). The most common medications were corticosteroids (91%) and methotrexate (35%) and the most common procedural treatment was tracheostomy (38%). The most efficacious treatment options were monoclonal antibodies (87%, n = 15) and corticosteroids (66%, n = 62) used in 22% and 91% of patients, respectively. The most commonly used monoclonal antibody therapy was infliximab (13%, n = 9).

Conclusion:

The most common presentation for pediatric RP includes chondritis of the ear, nose, and respiratory tract. The most effective treatment options include corticosteroids and monoclonal antibody therapy, such as infliximab. Our findings highlight increasing remission achieved with anti-rheumatic drugs and monoclonal antibody treatment, especially alongside corticosteroids.
Evaluating an Expanded Health Action Process Approach Model of Health Promotion to Predict Physical Activity Levels of Individuals With Chronic Health Conditions and Disabilities
Authors: Wu Jia Rung , Chan Fong , Tansey Timothy , Ditchman Nicole , Berven Norman , Hoyt William
Published: August 2024

Physical activity is associated with reduced stress, anxiety, and depression. This study evaluated autonomous motivation and social support for exercise in addition to the Health Action Process Approach (HAPA) model as predictors of physical activity among people with chronic health conditions and disabilities. This is secondary data analysis. Participants were 982 U.S. individuals with chronic health conditions and disabilities. Hierarchical regression analysis (HRA) was used to assess variable impact sequentially, and a serial multiple mediation analysis (SMMA) was utilized to test mediation effect. The HAPA model constructs, autonomous motivation, and social support for exercise accounted for 35% of the variance in physical activity scores, a large effect size. Commitment was the strongest predictor, followed by autonomous motivation and self-efficacy. SMMA results indicated that autonomous motivation was associated with self-efficacy and commitment, and these factors were significantly associated with physical activity. Self-efficacy and commitment significantly mediated the relationship between autonomous motivation and physical activity. Autonomous motivation thus plays an important role in predicting the physical activity levels of adults with disabilities, warranting the inclusion of an autonomy construct in the HAPA model.
Adaptive consensus control and attack detection of nonlinear multiagent systems under false data injection attacks and unknown control directions
Authors: Pan Yingnan , Ding Bingjie , Zhang Linchuang
Published: August 2024

This paper investigates the consensus control problem for strict-feedback nonlinear multiagent systems (MASs) under false data injection attacks (FDIAs) and unknown control directions. Different from the existing results, an attack detection mechanism that only uses the information of adjacent agents is designed to judge the occurrence times of the FDIAs, and the negative effects of FDIAs are eliminated by proposing a switching topologies strategy. By introducing the multiple Nussbaum functions, the multiple unknown control directions are addressed, while the effects of these functions enhance each other rather than offset each other. It is shown that the consensus performance and the boundedness of all the signals in the closed-loop systems can be ensured. Finally, the validity of the proposed control scheme is verified through a simulation example.
Staging a dialogue between Autonomist Marxists and Post-Marxists: The case of the alt-right multitude
Authors: Buarque Beatriz Lopes
Published: August 2024

Albeit in different ways, both Autonomist Marxists and Post-Marxists have proposed radical democratic theories. To Autonomist Marxists, the latest advances in capitalism would pave the way for global democracy. To Post-Marxists, the plurality of social movements would push society towards a radical model of democracy. Despite their contributions, both Autonomist Marxism and Post-Marxism have left underdeveloped the possibility that digital, affective capitalism could push society towards the opposite direction of global and radical democracy. This article explores the hypothesis that contemporary capitalism may have given birth to a multitude that aims at consolidating White, Western, and masculine supremacy. It argues that fantasies that have, for centuries, sustained the racist, xenophobic, and sexist ideological dimensions of capitalism have brought together multiple groups and individuals that have engaged in the collaborative production of conspiracy theories conveying the common belief that an idealised White/Western identity is under attack: the alt-right multitude. By merging part of the key features of the multitude proposed by Autonomist Marxists with what is known as a ‘Žižekian-Lacanian-Post-Marxist theory’, this article stages a dialogue between both schools of thought, opening new directions for research on how capitalism intersects with issues of race, ethnicity, and gender.
Removal of boron from wastewaters using valonia-tannin-based biosorbent produced via spray drying
Authors: Erdol-Aydin Nalan , Sezer Serhat , Esin Berk , Nasun-Saygili Gulhayat
Published: August 2024

The primary objective of this study is to assess the adsorption behavior of boron using a tannin-based biosorbent known as tannic acid resin, synthesized from Turkish acorns (valonia) through the spray-drying method. The resulting biosorbent, named Valex, underwent modification into a tannic acid resin-based structure, rendering it suitable for use as a biosorbent. Comprehensive characterization studies involving Fourier transform infrared, X-ray diffraction, scanning electron microscopy, and Brunauer-Emmett-Teller analysis were conducted on this biosorbent. The outcomes demonstrated the effectiveness of tannic acid resin, a tannin-based biosorbent, in removing boron from aqueous solutions. Various parameters such as pH, initial boron concentration, and adsorbent dosage were investigated for their impact on boron removal. The study also delved into adsorption kinetics, adsorption isotherm models, and adsorption thermodynamics. Maximum boron removal, reaching 92.9%, was achieved using 1 g of tannic acid resin-based biosorbent with an initial boron concentration of 8 mg L−1 within 6 h at pH 3. The Langmuir, Freundlich, Dubinin–Radushkevich, and Temkin isotherm models were applied to experimental data, with the Temkin model demonstrating a good fit. Adsorption kinetics were explored using pseudo-first-order, pseudo-second-order, Elovich, first-order, second-order, and intraparticle diffusion models, with the pseudo-second-order kinetic model fitting the data effectively. The negative values of Δ G° at all temperatures indicated the spontaneous nature of boron adsorption on the tannin resin, and the positive value of Δ H° suggested the endothermic nature of adsorption. This study shows the efficacy of Valex in boron adsorption and suggests its potential application as an effective method for boron removal. This study's findings on the impact of various parameters on boron removal provide insights for optimizing the boron adsorption process in practical applications.
Association between PPARγ polymorphisms and neurological functional disability of ischemic stroke
Authors: Yan Ran , Qiu Xin , Dai Yalun , Jiang Yingyu , Gu Hongqiu , Jiang Yong , Ding Lingling , Cheng Si , Meng Xia , Wang Yilong , Zhao Xingquan , Li Hao , Wang Yongjun , Li Zixiao
Published: August 2024

Peroxisome proliferator-activated receptor-γ ( PPARγ) plays a protective role against brain injury after stroke in mice. However, the relationship between PPARγ gene polymorphisms and the functional outcome of acute ischemic stroke (AIS) remains unknown. 8822 patients from The Third China National Stroke Registry (CNSR-III) after whole-genome sequencing, two functional single nucleotide polymorphisms(SNPs) in PPARγ, rs1801282 C > G and rs3856806 C > T, were further analysed. The primary outcome was neurological functional disability at three months. Of the 8822 patients, 968 (11.0%) and 3497 (39.6%) were carriers of rs1801282 and rs3856806, respectively. Carriers of rs3856806 showed reduced risks for three-month neurological functional disability (OR, 0.84; 95% CI, 0.73–0.98; p = 0.02) and reduced risks for higher infarct volume (OR 0.90, 95% CI, 0.81–0.99, p = 0.04). They also had a reduced risk of neurological functional disability only in case of lower baseline IL-6 levels (OR 0.64, 95% CI 0.48–0.84, Pinteraction = 0.01). Carriers of rs1801282 had a reduced risk for three-month neurological functional disability (OR 0.77, 95% CI, 0.61–0.99, p = 0.04). Our study suggested that PPARγ polymorphisms are associated with a reduced risk for neurological functional disability and higher infarct volume in AIS. Therefore, PPARγ can be a potential therapeutic target in AIS.
Comparative Evaluation of Falling Weight Deflectometer, Traffic Speed Deflectometer and Rapid Pavement Tester in Deflection Measurement
Authors: Hamidi Arman , Mirhosseini Ali Foroutan , Hoff Inge , Mork Helge , Grannes Kim Rune Bragstad , Aursand Per Otto
Published: August 2024

This study intends to compare deflections obtained from traffic speed deflection devices (TSDDs) with the deflections of the falling weight deflectometer (FWD). For this purpose, deflections were measured on five sections of three roads in the Norwegian road network using traffic speed deflectometer (TSD) and rapid pavement tester (Raptor). Deflections were also measured using FWD at three different temperatures and the curves of FWD deflections versus temperature (FWD temperature-dependent deflection curves) were obtained. These curves were used to correct the effect of temperature difference. It was shown that both TSD and Raptor have the potential to detect structural deficiencies; however, TSD had better consistency with FWD with regard to deflection values and deflection basin parameters. A refinement was then made to make the Raptor data more consistent with FWD data. Calculating bearing capacity before and after refinement revealed that refining Raptor data can substantially increase the consistency between Raptor and FWD.