bluuebunny/crossref_metadata_2025 huggingface dataset:
Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of N6-Methyladenosine RNA Modification Regulators in Human Cancers
Authors: Li Rui , Yin Yun-Hong , Ji Xiu-Li , Liu Xiao , Li Jian-Ping , Qu Yi-Qing
Published: June 2021

N6-methyladenosine RNA modification plays a significant role in the progression of multiple tumorigenesis. Our study identified the imperative role of m6A regulators in the tumor immune microenvironment, survival, stemness score, and anticancer drug sensitivity of pan-cancer. The Wilcox test was to identify the differential expression between 17 m6A regulators across 33 TCGA cancer types and their normal tissues from UCSC Xena GDC pan-cancer. Survival analysis of m6A-related regulators in 33 TCGA cancer types was identified using the “survival” and “survminer” package. The Spearman correlation test and Pearson correlation test were used to identify the correlation relationship between m6A regulators expression and tumor microenvironment, tumor stem cell score, and drug sensitivity of anticancer drugs. ConsensusPathDB was used for exploring m6A regulators functional enrichment. The 17 (METTL3, WTAP, METTL14, RBM15, RBM15B, VIRMA, HNRNPC, HNRNPA2B1, YTHDC1, ZC3H13, YTHDF1, YTHDC2, YTHDF2, IGF2BP3, IGF2BP1, FTO, and ALKBH5) m6A regulators were differentially expressed in 18 TCGA cancer types and adjacent normal tissues. Correlation analysis indicated that the relationship between the expression of 17 m6A regulators and tumor microenvironment indicated that the higher expression of m6A regulators, the higher the degree of tumor stem cells. The anticancer drug sensitivity analysis indicated that ZC3H13 expression had a positive relationship with anticancer drugs such as selumetinib, dabrafenib, cobimetinib, trametinib, and hypothemycin (p < 0.001). YTHDF2 expression was significantly negatively correlated with the anticancer drug dasatinib (p < 0.001). The pan-cancer immune subtype analysis showed that the 17 m6A regulators were significantly different in immune subtype C1 (wound healing), C3 (inflammatory), C2 (IFN-gamma dominant), C5 (immunological quiet), C4 (lymphocyte depleted), and C6 (TGF-beta dominant) (p < 0.001). Our study provides a comprehensive insight for revealing the significant role of m6A regulators in the tumor immune microenvironment, stemness score, and anticancer drug sensitivity of human cancers.
Policy and Food Consumption: What Nutrition Guidelines Are Swiss Children Meeting and What Determines Adherence?
Authors: Rangelov Natalie , Nogueira Avelar e Silva Raquel , Suggs L. Suzanne
Published: June 2021

Objectives: To describe the adherence of the children to the Swiss Society for Nutrition (SSN) dietary guidelines, assess determinants of adherence, and compare these findings with a previous study in the same population.

Methods: Data from 312 children ages 5–12 were collected through a survey and a 2-day food record. The associations of children- and parent-related factors with adherence of the children to guidelines were assessed by logistic regression analyses.

Results: SSN guidelines were not met for any food category, although there were improvements: vegetables (4.5% in this study vs. 0% in the previous study), sweets, snacks, and soft drinks (SSD) (12.5 vs. 9.5%), and fruit (45.5 vs. 10.4%). Higher Body Mass Index (BMI) in children was associated with higher adherence to guidelines for protein intake. Higher parental BMI was associated with higher adherence to vegetables. Parental lower educational level was associated with higher adherence for cereal.

Conclusion: Despite improvements since the last eating behavior assessment in this population, children consume too little fruit, vegetables, cereal, and milk and dairy products, and too much SSD and proteins. Further efforts are needed to promote healthy eating to children and achieve adherence to guidelines.
Interventional and Non-interventional Medical Rehabilitation Approaches to Axial Spine Pain in Vertebral Metastatic Disease
Authors: Sarma Krishna , Kohns David J. , Berri Maryam A. , Joyce Elizabeth , Smith Sean R.
Published: June 2021

As targeted therapies help patients with advanced cancer live longer, interventions for management of axial spine pain will become more common. Unfortunately, the indications for and safety of these procedures have been relatively unexplored compared with non-cancer adults. This review focuses on the following aspects of axial spine pain management in patients with vertebral metastatic disease: (1) pathophysiology and symptoms of cancer- and non-cancer-related spine pain; (2) safety and efficacy of non-interventional rehabilitation approaches to treat this pain; (3) considerations for interventional pain approaches to acute and chronic pain in patients with vertebral metastatic disease. This review also summarizes gaps in the literature and describes specific cases in which the described interventions have been applied.
Neutropenia Is Not Associated With the Outcomes in Patients With Kawasaki Disease
Authors: Tang Yunjia , Gang Miao , Qian Weiguo , Ma Jin , Xu Qiuqin , Lv Haitao
Published: June 2021

Objective: To investigate the outcomes of coronary artery lesions (CALs) and intravenous immunoglobulin (IVIG) resistance in patients with and without neutropenia during the disease course and to explore the relationships between Δ absolute neutrophils count (ΔANC) and the outcomes.

Methods: We retrospectively reviewed the medical records of patients hospitalized in Children's Hospital of Soochow University with a main diagnosis of KD during January 2019 and December 2019. 1:4 propensity score matching was carried out to adjust the baseline characteristics. Smoothed plots and threshold effect analyses were performed to reveal the relationships between ΔANC and the outcomes.

Results: Of the 438 patients enrolled, 75 (17.1%) were neutropenia cases and 363 (82.9%) were non-neutropenia cases. Patients with neutropenia were younger, had lower levels of initial ANC, white blood cell (WBC) count and C-reactive protein (CRP). Propensity score matching included 75 neutropenia and 247 non-neutropenia patients. No significant difference was found between neutropenia and non-neutropenia groups regarding CALs, coronary artery aneurysms, irregular coronary lumen, IVIG resistance and days of fever duration. There was a non-linear relationship between ΔANC and IVIG resistance. However, threshold effect analysis showed the incidence of IVIG resistance decreased with increasing ΔANC before the turning point (ΔANC = 1.6) (OR = 0.65, 95% CI = 0.50–0.8.4 P = 0.001). On the other hand, there was a linear relationship between ΔANC and CALs, even after adjusting the confounders (OR = 1.06, 95% CI = 1.02–1.11, P = 0.008).

Conclusions: Neutropenia after IVIG was not exactly associated with the outcomes. However, ΔANC was in relation to CALs and IVIG resistance.
Multisystemic Inflammatory Syndrome and Thrombotic Microangiopathy as Complications of COVID-19 in a Child: A Case Report
Authors: Oi Samira Shizuko Parreão , Muniz Monique Pereira Rêgo , Faria Igor Murad , Filho Natalino Salgado , Brito Dyego José Araújo de , Lages Joyce Santos , Lauande Letícia Pádua , Oliveira Thina Klicia Mendonça , Cunha Kaile de Araújo , Neves Precil Diego Miranda de Menezes , Silva Gyl Eanes Barros
Published: June 2021

Clinical presentations of the novel coronavirus (SARS-CoV-2) infection are quite varied, ranging from asymptomatic conditions to potentially fatal disease. The kidney is one of the affected targets of coronavirus disease (COVID-19) complications, and renal dysfunction is a significant prognostic factor for mortality. This report describes a series of clinical complications in a previously healthy child who developed nephritic syndrome with a concomitant SARS-CoV-2 infection. These complications include acute kidney injury that progressed to chronicity, multisystemic inflammatory syndrome, Kawasaki-like syndrome, and thrombotic microangiopathy.
Psychological Outcomes and Predictors of Weight Loss in Adolescents With Severe Obesity Following a Reversible Endoscopic Bariatric Procedure
Authors: Klemenčič Simona , Bujišić Ana , Hribernik Neža Štiglic , Battelino Tadej , Homan Matjaž , Orel Rok , Kotnik Primož
Published: June 2021

Introduction: Adolescent and children obesity is a growing concern worldwide. Bariatric surgery is used as an effective treatment for adolescents with obesity and provides physical and mental health benefits. Application of alternative, minimally invasive, safe, and reversible endoscopic procedures, such as the Duodenojejunal bypass liner (DJBL), has been recently suggested as an effective treatment for adolescents with obesity. We explored specific psychological outcomes of adolescents with obesity during a year of follow-up after undergoing a reversible endoscopic bariatric procedure, and a year after removal. We were also interested in identifying psychological factors that could predict successful weight loss after the procedure.

Methods: Nineteen adolescent with severe obesity undergoing DJBL procedure were psychologically assessed in an open-label, prospective clinical trial (NTC0218393), at the implantation of device and at the removal of device after 12 months. Control group of 26 adolescents with severe obesity were recruited from the same outpatient clinic undergoing only conservative treatment. In addition, adolescents from the intervention group were followed for 12 months after the removal of the device. The Youth Self Report (YSR) was used to assess adolescents' emotional and behavioural problems; The Multidimensional Body-Self Relations Questionnaire (MBSRQ) to assess body image and The Eating Disorder Examination Questionnaire (EDE-Q) to assess attitudes and behaviours related to eating disorder.

Results: Significant improvements in somatic complain (F = 12.478, p = 0.001), emotional and behavioural problems (F = 7.169, p = 0.011) and food restraining (F = 9.605, p = 0.004) were found in the intervention group at device removal compared to the control group. Moreover, at the time of device removal compared to baseline, improvements in several psychological outcomes were found (F = 32.178 p = 0.000 for emotional and behavioural problems). Adolescents also became more satisfied with their appearance (F = 6.789, p = 0.019). Majority of observed changes remained stable at the next follow up a year after the device removal. Significant predictors of successful weight loss at device removal were fewer overeating episodes (B = 0.147, p = 0.022) and lower body satisfaction (B = 0.932, p = 0.013).

Discussion: Following a reversible bariatric procedure, improvements of psychological (emotional and behavioural) factors were found in adolescents with severe obesity. Psychological predictors of successful weight loss were identified, showing the greatest importance of eating behaviour and body satisfaction in successful weight loss.
Is It Really Feasible to Use Budesonide–Formoterol as Needed for Mild Persistent Asthma? A Systematic Review and Meta-Analysis
Authors: Tong Xiang , Liu Tao , Li Zhenzhen , Liu Sitong , Fan Hong
Published: June 2021

Background: Previous studies suggest that inhaled budesonide-formoterol used as needed could effectively reduce the severe exacerbation of mild persistent asthma. However, there are some differences between these studies, so we conducted a meta-analysis.

Methods: We searched PubMed, Ovid MEDLINE, Cochrane Library and several web search engines to screen the literature until March 25, 2020 and used risk ratios (RR), odds ratios, hazard ratios (HR) and weighted mean differences with 95% confidence intervals (CI) to evaluate the pooled effects. Adolescent/adult patients with mild persistent asthma who used budesonide–formoterol as needed were included in this study. The primary outcome was to investigate the superiority of budesonide–formoterol as needed in reducing severe exacerbations in patients with mild persistent asthma. STATA 12.0 software was used for statistical analysis.

Results: Across all 4 articles, 4,023 patients used budesonide–formoterol as needed (budesonide–formoterol group), 4,042 patients used budesonide maintenance plus short-acting β2-agonist (SABA) as needed (budesonide group), and 1,500 patients used SABA as needed (SABA group). The results showed that the incidence of severe exacerbations and the time to first severe exacerbation in the budesonide–formoterol group were significantly different from those for the SABA group (RR = 0.46, 95% CI = 0.36–0.59, p < 0.001; HR = 0.43, 95% CI = 0.33–0.56, p < 0.001; respectively), but there was no difference between the budesonide–formoterol group and budesonide group (RR = 0.86, 95% CI = 0.62–1.04, p = 0.093; HR = 0.77, 95% CI = 0.57–1.03, p = 0.079; respectively). There were statistically significant differences in the forced expiratory volume in 1 second and in the responses to the Asthma Control Questionnaire-5 between the budesonide-formoterol group and the SABA group, but the differences were not clinically significant. In addition, the daily dose of budesonide in the budesonide–formoterol group was significantly lower than that in the budesonide group, and there was no difference in the incidence of adverse events among the three groups.

Conclusion: In summary, budesonide–formoterol used as needed may reduce severe exacerbation in adolescent/adult patients with mild persistent asthma.
Complexity and Entropy in Legal Language
Authors: Friedrich Roland
Published: June 2021

We study the language of legal codes from different countries and legal traditions, using concepts from physics, algorithmic complexity theory and information theory. We show that vocabulary entropy, which measures the diversity of the author’s choice of words, in combination with the compression factor, which is derived from a lossless compression algorithm and measures the redundancy present in a text, is well suited for separating different writing styles in different languages, in particular also legal language. We show that different types of (legal) text, e.g. acts, regulations or literature, are located in distinct regions of the complexity-entropy plane, spanned by the information and complexity measure. This two-dimensional approach already gives new insights into the drafting style and structure of statutory texts and complements other methods.
DNA Metabarcoding for Quality Control of Basil, Oregano, and Paprika
Authors: Raclariu-Manolică Ancuţa Cristina , Anmarkrud Jarl Andreas , Kierczak Marcin , Rafati Nima , Thorbek Birgitte Lisbeth Graae , Schrøder-Nielsen Audun , de Boer Hugo J.
Published: June 2021

Herbs and spices are some of the most vulnerable products in terms of fraud and adulteration in the food sector. Although standard analytical methods are accurate for quality control of specific lead or marker compounds, they cannot accurately assess the entire species composition of many marketed products. Complementary analytical approaches are thus often used for comprehensive screening of herbs and spices. In this study we evaluate DNA metabarcoding for the identification and authentication of 62 products, containing basil, oregano, and paprika collected from different retailers and importers in Norway. Our results show varying degrees of discrepancy between the constituent species and those listed on the product labels, despite high product authenticity. We suggest the false positives result from the sensitivity of DNA metabarcoding and filtering thresholds should be integrated into protocols to reduce false positives. Our results highlight how integrating DNA metabarcoding into the toolbox of analytical methods for quality control of fresh and/or processed plant-based food can improve product quality.
Can Reclaimed Water Be Used for Sustainable Food Production in Aquaponics?
Authors: Cifuentes-Torres Liliana , Correa-Reyes Gabriel , Mendoza-Espinosa Leopoldo G.
Published: June 2021

Aquaculture is a technology used for the production of animal protein but produces a great amount of waste that decreases productivity and adversely affects the environment. Sedimentation and filtration have been used for the treatment of the suspended fraction of these wastes although dissolved substances like nutrients can be an asset. Therefore, the management of aquaculture waste remains a challenge. Aquaponics is a technology that can eliminate dissolved N and P from aquaculture systems as they serve as nutrients for plants, which are absorbed through the roots and are incorporated into their tissues. Several reports and studies exist on the benefits of aquaponic systems for the combined production of plants and aquatic organisms and its advantages in terms of economics and environmental protection. The great majority of the studies use the wastewater from the aquatic production tanks as a source of nutrients for plants production. However, domestic or municipal wastewater is a resource that has been used extensively in other production systems such as conventional agriculture and aquaculture, yet its potential as a source of water for aquaponics has not been established. The current analysis hypothesizes that reclaimed water can be used for aquaponics. Despite the extensive use of reclaimed water in agriculture and aquaculture and the low risk to human health when properly managed, there are no academic studies that have tackled this issue. In order to overcome the generalized mistrust of the public in consuming crops irrigated with reclaimed water or fish growing in reclaimed water, it is recommended that only ornamental fish and plants would be cultivated by this method. There is an urgent need for studies to verify the safety and advantages of such cultivation technique. Finally, it is necessary to establish guidelines for the responsible use of reclaimed water in aquaponics.
Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding
Authors: Aguilar Miguel , Prieto Pilar
Published: June 2021

Genomic architecture facilitates chromosome recognition, pairing, and recombination. Telomeres and subtelomeres play an important role at the beginning of meiosis in specific chromosome recognition and pairing, which are critical processes that allow chromosome recombination between homologs (equivalent chromosomes in the same genome) in later stages. In plant polyploids, these terminal regions are even more important in terms of homologous chromosome recognition, due to the presence of homoeologs (equivalent chromosomes from related genomes). Although telomeres interaction seems to assist homologous pairing and consequently, the progression of meiosis, other chromosome regions, such as subtelomeres, need to be considered, because the DNA sequence of telomeres is not chromosome-specific. In addition, recombination operates at subtelomeres and, as it happens in rye and wheat, homologous recognition and pairing is more often correlated with recombining regions than with crossover-poor regions. In a plant breeding context, the knowledge of how homologous chromosomes initiate pairing at the beginning of meiosis can contribute to chromosome manipulation in hybrids or interspecific genetic crosses. Thus, recombination in interspecific chromosome associations could be promoted with the aim of transferring desirable agronomic traits from related genetic donor species into crops. In this review, we summarize the importance of telomeres and subtelomeres on chromatin dynamics during early meiosis stages and their implications in recombination in a plant breeding framework.
Pre-Exposure Cybersickness Assessment Within a Chronic Pain Population in Virtual Reality
Authors: Brown Phillip , Powell Wendy
Published: June 2021

Virtual Reality (VR) is being increasingly explored as an adjunctive therapy for distraction from symptoms of chronic pain. However, using VR often causes cybersickness; a condition with symptoms similar to those of motion and simulator sickness. Cybersickness is commonly assessed using self-report questionnaires, such as the Simulator Sickness Questionnaire (SSQ), and is traditionally conducted post-exposure. It’s usually safe to assume a zero baseline of cybersickness as participants are not anticipated to be exhibiting any sickness symptoms pre-exposure. However, amongst populations such as chronic pain patients, it’s not unusual to experience symptoms of their condition or medication which could have a confounding influence on cybersickness symptom reporting. Therefore, in population groups where illness and medication use is common, assuming baseline is not necessarily desirable. This study aimed to investigate cybersickness baseline recordings amongst a chronic pain population, and highlights how deviations from an assumed baseline may incorrectly infer adverse effects arising from VR exposure. A repeated measures study design was used, in which twelve participants were assessed pre and post VR exposure via SSQ. Significant differences were found between actual and assumed pre-exposure baseline scores. Furthermore, we found significant differences between actual and assumed increases in cybersickness scores from baseline to post exposure. This study highlights that clinical sub-populations cannot be assumed to have a zero baseline SSQ score, and this should be taken into consideration when evaluating the usability of VR systems or interventions for participants from different demographics.
Koalas Give Tree Bark a Licking
Authors: Mella Valentina S. A. , Van Stan John T.
Published: June 2021

All animals need water to live, but not all of them need to drink it from their surroundings. Drinking free water from rivers or puddles is just one of many ways that animals get the water they need. Until recently, koalas were thought to get most of their water from the leaves that they eat. But, after years of koala watchers getting caught in the rain, the scientists and volunteers began sharing similar, strange stories. These sleepy animals were waking up during storms and giving the tree bark a lively licking! Surprisingly, koalas appear to drink a type of free water rarely studied: stemflow. This is rainwater that drains down tree bark, and it is not just water. Stemflow picks up all types of things from the bark as it drains, from nutrients and pollutants to bacteria and fungi, raising many new questions for koala scientists.
Modeling Spatial Interaction in Stochastic Frontier Analysis
Authors: Areal Francisco J. , Pede Valerien O.
Published: June 2021

We compare farm level efficiency rankings derived from non-spatial and a variety of spatial model specifications that account for unobserved heterogeneity in both the production and the efficiency sides of the stochastic frontier model in an empirical application on rice farming in the Philippines. We show how not accounting for unobserved spatial heterogeneity affects efficiency estimates and farm efficiency rankings. When not accounting for unobserved spatial heterogeneity efficiency, models show farms to be relatively more inefficient than they actually are (i.e., once unobserved spatial heterogeneity is incorporated in the models). More importantly from a policy perspective, the rankings of the farms in terms of efficiency are altered once unobserved spatial heterogeneity is incorporated in efficiency models. We recommend the use of unobserved effects in both production and efficiency within the stochastic frontier analysis framework to avoid making any misleading recommendations to farmers and policymakers.
A Prediction of NPVR ≥ 80% of Ultrasound-Guided High-Intensity Focused Ultrasound Ablation for Uterine Fibroids
Authors: Yang Mei-Jie , Yu Ren-Qiang , Chen Wen-zhi , Chen Jin-Yun , Wang Zhi-Biao
Published: June 2021

Objective: To evaluate factors in predicting the treatment outcome of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for uterine fibroids with a non-perfused volume ratio (NPVR) of at least 80%.

Methods: One thousand patients with uterine fibroids who received USgHIFU were enrolled. Thirty-two independent variables of four dimensions of data set, including general information of patients, clinical symptoms, laboratory tests, and fibroid imaging characteristics, were used to investigate the potential predictors of the NPVR of at least 80% by multivariate logistic regression. NPVR was the gold standard for evaluating the efficiency of HIFU ablation, and a NPVR of at least 80% was considered sufficient ablation, while partial ablation was defined as having an NPVR of <80%.

Results: Out of 1,000 fibroids, 758 obtained sufficient ablation and 242 obtained partial ablation, and the median NPVR was 88.3% (interquartile range: 80.3–94.8%). The probability of NPVR reaching 80% fibroids with a signal intensity of T2WI of hypointense, isointense, and hyperintense was 86.4, 76.5, and 62.6%, respectively; fibroids with an enhancement type of T1WI of slight, irregular, and regular was 81.5, 73.6, and 63.7%, respectively; and fibroids with uterine anteroposterior of 30–130 mm was 57.7–78.3%, respectively. In patients with a platelet count of 50 × 109/L−550 × 109/L, the probability of NPVR reaching 80% is from 53.4 to 80.1%, respectively.

Conclusions: In predicting NPVR ≥ 80%, the signal intensity on T2WI was the most important factor affecting ablative efficiency, followed by enhancement type on T1WI, uterine anteroposterior, and platelet count.
Long Non-coding RNAs in Traumatic Brain Injury Accelerated Fracture Healing
Authors: Guo Guoning , Gou Yajun , Jiang Xingyu , Wang Shuhong , Wang Ruilie , Liang Changqiang , Yang Guang , Wang Tinggang , Yu Anyong , Zhu Guoyan
Published: June 2021

It is commonly observed that patients with bone fracture concomitant with traumatic brain injury (TBI) had significantly increased fracture healing, but the underlying mechanisms were not fully revealed. Long non-coding RNAs (lncRNAs) are known to play complicated roles in bone homeostasis, but their role in TBI accelerated fracture was rarely reported. The present study was designed to determine the role of lncRNAs in TBI accelerated fracture via transcriptome sequencing and further bioinformatics analyses. Blood samples from three fracture-only patients, three fracture concomitant with TBI patients, and three healthy controls were harvested and were subsequently subjected to transcriptome lncRNA sequencing. Differentially expressed genes were identified, and pathway enrichment was performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. High-dimensional data visualization by self-organizing map (SOM) machine learning was applied to further interpret the data. An xCell method was then used to predict cellular behavior in all samples based on gene expression profiles, and an lncRNA–cell interaction network was generated. A total of 874 differentially expressed genes were identified, of which about 26% were lncRNAs. Those identified lncRNAs were mainly enriched on TBI-related and damage repair-related pathways. SOM analyses revealed that those differentially expressed lncRNAs could be divided into three major module implications and were mainly enriched on transcriptional regulation and immune-related signal pathways, which promote us to further explore cellular behaviors based on differentially expressed lncRNAs. We have predicted that basophils, CD8+ T effector memory cells, B cells, and naïve B cells were significantly downregulated, while microvascular endothelial cells were predicted to be significantly upregulated in the Fr/TBI group, was the lowest and highest, respectively. ENSG00000278905, ENSG00000240980, ENSG00000255670, and ENSG00000196634 were the most differentially expressed lncRNAs related to all changes of cellular behavior. The present study has revealed for the first time that several critical lncRNAs may participate in TBI accelerated fracture potentially via regulating cellular behaviors of basophils, cytotoxic T cells, B cells, and endothelial cells.
MRI With Intratympanic Gadolinium: Comparison Between Otoneurological and Radiological Investigation in Menière's Disease
Authors: Neri Giampiero , Tartaro Armando , Neri Letizia
Published: June 2021

Objectives/hypothesis: To compare findings obtained using both magnetic resonance imaging plus intratympanic gadolinium and audiovestibular testing for Menière's disease.

Study design: Retrospective cohort study.

Methods: Patients with definite unilateral Menière's disease (n = 35) diagnosed according to 2015 Barany Criteria were included. Three-dimensional real inversion recovery (3D-real-IR) MRI was executed 24 h after intratympanic gadolinium injection to assess the presence and degree of endolymphatic hydrops. Pure tone audiometry, bithermal caloric test, head impulse test, ocular, and cervical VEMPs using air-conducted sound were performed to evaluate the level of hearing and vestibular loss. The results were compared to verify precision of the method in providing correct diagnoses.

Results: Different degrees of endolymphatic hydrops were observed in the MRI of the cochlea and vestibule in the affected ears of Menière's disease patients, even though it was impossible to radiologically distinguish the two otolithic structures separately. The correlation between the degree of linked alterations between instrumental and MRI testing was statistically significant. In particular, an 83% correspondence with audiometry, a 63% correspondence for cVEMPs and 60% correspondence for cVEMPs were seen. While for HIT the accordance was 70 and 80% for caloric bithermal test.

Conclusions: MRI using intratympanic gadolinium as a contrast medium has proved to be a reliable and harmless method, even though there is an objective difficulty in disclosing macular structures. The study revealed that there is no complete agreement between instrumental values and MRI due to the definition of the image and fluctuation of symptoms. The present work highlights the greater (but not absolute) sensitivity of otoneurological tests while MRI, although not yet essential for diagnosis, is certainly important for understanding the disease and its pathogenic mechanisms.
Seroprevalence of Brucellosis in Buffalo Worldwide and Associated Risk Factors: A Systematic Review and Meta-Analysis
Authors: Shi Jun-Feng , Gong Qing-Long , Zhao Bo , Ma Bao-Yi , Chen Zi-Yang , Yang Yang , Sun Yu-Han , Wang Qi , Leng Xue , Zong Ying , Li Jian-Ming , Du Rui
Published: June 2021

Background: Brucellosis is an important zoonotic disease caused by Brucella spp. Brucellosis is widely distributed in more than 160 or 170 countries around the world, where it poses a huge threat to animal husbandry and human health. About 150 million head of water buffalo, distributed across more than 40 countries worldwide, are kept for the purposes of service, milk, and meat. High incidence of Brucella spp. in buffalo has negatively affected dairy products and meat products.

Results: We searched all research related to seroprevalence of brucellosis in water buffalo anywhere in the world in PubMed, Science Direct, SpringerLink, China National Knowledge Infrastructure, Wanfang Database, and VIP Chinese Journal Databases. A total of 26 articles published from 1985 to 2020 met the final selection criteria. The overall seroprevalence of buffalo brucellosis worldwide was 9.7%. The seroprevalence before 2010 (20.8%) (95% CI: 5.6–42.2) was much higher than the seroprevalence rate from 2010 to 2020 (4.2%) (95% CI: 1.8–7.5). Subgroup analysis by feeding mode found that the point estimate of seroprevalence in stock buffalo (11.5%) (95% CI: 3.6–23.0) was higher than that in captive buffalo (10.6%) (95% CI: 4.9–18.1). Subgroup analysis by farming mode found that the seroprevalence was higher in captive-bred buffalo (10.7%) (95% CI: 6.6–15.7) than in intensively farmed buffalo (8.5) (95% CI: 0.9–22.2). The seroprevalence in buffalo living in dry lands (6.4%) (95% CI: 2.0–12.9) is greater than that in buffalo living in wetlands (5.1%) (95% CI: 1.8–10.4) (P < 0.05). The seroprevalence in female buffalo (10.1%) (95% CI: 3.4–19.7) was higher than that in male buffalo (4.4%) (95% CI: 2.0–7.4). The seroprevalence in lactating buffalo was higher than that in buffalo of other ages (26.9%) (95% CI: 1.8–66.5). Subgroup analysis by detection method found that the seroprevalence detected by the complement fixation test (27.3%) (95% CI: 0.7–70.8) was much higher than that detected by other methods.

Conclusion: The results of this meta-analysis showed that buffalo brucellosis infection is very common in buffalo herds around the world. Although the seroprevalence of brucellosis in buffalo and humans is relatively low, serious effects upon animal husbandry and public health make it necessary to take effective control and preventive measures to control the spread of this disease.
Development of a Real-Time Quantitative RT-PCR Assay for Detection of Bovine Rhinitis B Virus
Authors: Xie Yi-Lun , Lv Dian-Hong , Wen Xiao-Hui , Zhai Qi , Luo Man-Lin , Wei Wen-Kang , Chen Qin-Ling , Zhai Shao-Lun
Published: June 2021

Bovine rhinitis B virus (BRBV) has been frequently identified in cattle diagnosed with bovine respiratory disease complex (BRDC) in recent years, suggesting its potential contribution to BRDC. The goal of this study was to develop a TaqMan-based real-time quantitative RT-PCR assay for efficient BRBV detection. A pair of primers and a probe were designed based on the 3D gene of the BRBV genome. The assay was specific for BRBV and able to exclude bovine rhinitis A virus, foot-and-mouth disease virus and Senecavirus A. The limit of detection of the assay was 4.46 copies per reaction. A standard curve was plotted, with a coefficient of determination of 0.999 in the concentration range of 100-108 copies/μl. The reproducibility of the assay was acceptable, with the standard deviations of cycle threshold values lower than 1.00 in both intra- and inter-assay. Of 200 samples collected from 150 head of cattle in recent years in China, 11% (22/200) of the samples tested positive in the assay, i.e., 4.6% (7/150) of the cattle were BRBV positive. This study provides an efficient diagnostic tool for the epidemiological investigations of BRBV.
Rationale of an Advanced Integrative Approach Applied to Autism Spectrum Disorder: Review, Discussion and Proposal
Authors: Ferreira María Luján , Loyacono Nicolás
Published: June 2021

The rationale of an Advanced Integrative Model and an Advanced Integrative Approach is presented. In the context of Allopathic Medicine, this model introduces the evaluation, clinical exploration, diagnosis, and treatment of concomitant medical problems to the diagnosis of Autism Spectrum Disorder. These may be outside or inside the brain. The concepts of static or chronic, dynamic encephalopathy and condition for Autism Spectrum Disorder are defined in this model, which looks at the response to the treatments of concomitant medical problemsto the diagnosis of Autism Spectrum Disorder. (1) Background: Antecedents and rationale of an Advanced Integrative Model and of an Advanced Integrative Approach are presented; (2) Methods: Concomitant medical problems to the diagnosis of Autism Spectrum Disorder and a discussion of the known responses of their treatments are presented; (3) Results: Groups in Autism are defined and explained, related to the responses of the treatments of the concomitant medical problems to ASD and (4) Conclusions: The analysis in the framework of an Advanced Integrative Model of three groups including the concepts of static encephalopathy; chronic, dynamic encephalopathy and condition for Autism Spectrum Disorder explains findings in the field, previously not understood.
Transcriptome Profiling Reveals Molecular Changes during Flower Development between Male Sterile and Fertile Chinese Cabbage (Brassica rapa ssp. pekinensis) Lines
Authors: Hu Jingfeng , Lan Mei , Xu Xuezhong , Yang Hongli , Zhang Liqin , Lv Fengxian , Yang Huiju , Yang Ding , Li Chongjuan , He Jiangming
Published: June 2021

Male sterility exists widely in flowering plants and is used as a fascinating tool by breeders for creating hybrid varieties. Herein, stamen samples from male sterile CCR20000 and male fertile CCR20001 lines during two developmental stages were employed to elucidate the molecular changes during flower development in fertile and sterile Chinese cabbage lines. RNA-seq revealed weak transcriptional activity in the sterile line, which may have led to the abnormal stamen development. The differentially expressed genes were enriched in plant hormone, carbon metabolism, and biosynthesis of amino acid pathways. Important genes with opposite patterns of regulation between the two lines have been associated with the male sterility trait. Members of the transcription factor families such as AP2, MYB, bHLH, and WRKY were highly active in the regulation of structural genes involved in pollen fertility. This study generated important genomic information to support the exploitation of the male sterility trait in Chinese cabbage breeding programs.
Polyvinylidene Fluoride-Based Metasurface for High-Quality Active Switching and Spectrum Shaping in the Terahertz G-Band
Authors: Danila Octavian
Published: June 2021

We report theoretical investigations performed in the terahertz G-band, in the 228–232 GHz spectral window for a piezoelectrically-responsive ring-cone element metasurface composed of polyvinylidene fluoride (PVDF)/Silicon and PVDF/Silica glass. The choosing of this spectral window is motivated by a multitude of applications in terahertz detection and terahertz imaging, that commonly make use of this band. The uniqueness of the envisioned architecture resides in the combination between the readily-available polyvinylidene fluoride polymer and silicon/silica glass substrates, together with the introduction of an extra degree of freedom, in the form of a ring-cone architecture, and the active control of the geometric sizes through the longitudinal piezoelectric effect exhibited by the polymer. The spectral response of the metasurface is dependent on the combination between the polymer elements and the substrate, and ranges from near-zero absorption switching to a resonant behavior and significant absorption. The interaction between the electromagnetic field and the polymer-based metasurface also modifies the phase of the reflected and transmitted waves over a full 2π range, permitting complete control of the electric field polarization. Moreover, we take advantage of the longitudinal piezoelectric effect of PVDF and analyze the spectrum shaping capability of the polymer-based metasurface. Our analysis highlights the capability of the proposed architecture to achieve complete electric field polarization control, near-zero optical switching and resonant behavior, depending on the geometries and sizes of the architecture elements resulting from construction considerations and from the externally applied voltages through the piezoelectric effect.
The Brain and the New Foundations of Mathematics
Authors: Melkikh Alexey V.
Published: June 2021

Many concepts in mathematics are not fully defined, and their properties are implicit, which leads to paradoxes. New foundations of mathematics were formulated based on the concept of innate programs of behavior and thinking. The basic axiom of mathematics is proposed, according to which any mathematical object has a physical carrier. This carrier can store and process only a finite amount of information. As a result of the D-procedure (encoding of any mathematical objects and operations on them in the form of qubits), a mathematical object is digitized. As a consequence, the basis of mathematics is the interaction of brain qubits, which can only implement arithmetic operations on numbers. A proof in mathematics is an algorithm for finding the correct statement from a list of already-existing statements. Some mathematical paradoxes (e.g., Banach–Tarski and Russell) and Smale’s 18th problem are solved by means of the D-procedure. The axiom of choice is a consequence of the equivalence of physical states, the choice among which can be made randomly. The proposed mathematics is constructive in the sense that any mathematical object exists if it is physically realized. The consistency of mathematics is due to directed evolution, which results in effective structures. Computing with qubits is based on the nontrivial quantum effects of biologically important molecules in neurons and the brain.
Increased reliability Cleanup engine and transmissions of tractors using nanomaterials
Authors: Lyalyakin V. P. , Solovev R. Yu. , Olhovatsky A. K. , Gitelman D. A.
Published: June 2021

The article presents some of the results and the results of the study to reduce the operational running and improving engine reliability , renovated CLD SHP, using nanomaterials.
IMPLEMENTASI SISTEM INFORMASI PENJUALAN BERBASIS CLIENT-SERVER (Studi Kasus: PT. SAMAFITRO CABANG BANDUNG)
Authors: Yunanto Rio , Muchtar Agus , Firdaus Dony Waluya
Published: June 2021

Samafitro's Branch Office is located in Bandung at 229th RE. Martadinata street. The problems before implementation of Sales Information System, sales activities was records and calculations by paper based. They are could result in human error, so that the accounting process and the generating reports are less quickly and accurately.

         Type of research that is using academic research. type of data that is using quantitative data and qualitative data. Research methods that is using explanatory and descriptive research. Technique of data collection that is using field research that consists of interview, observation and library research. Structure of system development that is using Waterfall.

            Financial reporting in Sales Information System of Samafitro in accordance with financial accounting standards. The computerized data processing is well, there by reducing the occurrence of human error and produce sales reports in the Supevisor Sales and supporters report on the accounts receivable in Supervisor Accounting.
PERANCANGAN SISTEM INFORMASI AKUNTANSI LAPORAN KEUANGAN (STUDI KASUS PADA PT. 212 SIAGA PROPERTY MANAGEMENT)
Authors: Widilestariningtyas Ony , Boedikartini Dwi Rahayu , Yunanto Rio
Published: June 2021

212 Siaga Property Management make a move area of service of security. When the writer research at financial administration, they making of financial statement still use the Microsoft Office Excel as a means of calculate. For the problems hence writer take the title "Desaign of Accounting Information Systems Financial Statement (Cases Study at PT. 212 Siaga Property Management with Microsoft Visual Basic 6.0 and SQL Server 2000 Bases of Client Server."

          Research design which writer applies research design with data primer/secunder, research type which writer applies basic and administer research, data type that writer use qualitative data and quantitative data, research method that writer use survey and descriptive research, data collecting technique that writer use field study consisted of by interview, observation and literature study, system development method that writer use methodology orienting at process, data and output. System development structure that writer use waterfall.

            After writer make the device of information system of financial statement accountancy, expected in processing of transaction and making of financial statement at  PT. 212 Siaga Property Management become computerized better according to standard of financial accounting and output yielded is Financial Statement Balance, Balance, Cash Flow, and Capital Change.
Optimasi Proses Pada Fungsi Pengelolaan Fasilitas Dalam Arsitektur Bisnis Menggunakan TOGAF ADM
Authors: Rachmawati Meidiani Juwita , Fajrillah Asti Amalia Nur
Published: June 2021

Pada era – digital ini, perkembangan teknologi informasi menjadikan TI sebagai cara bagi perusahaan untuk mencapai tujuannya. Tidak hanya membantu dalam proses pekerjaan namun juga dapat menjadi solusi dari sebuah permasalahan dan strategi bagi perusahaan. Dalam proses pengimplementasian TI, diperlukan perancangan dengan analisis yang mendalam sesuai dengan kondisi perusahaan. Hal ini bertujuan agar TI yang diterapkan dapat menjadi solusi, strategi, efektif dan efisien bagi perusahaan. Perkembangan TI ini juga mendorong perusahaan tipe manufaktur untuk terus berkembang. Pada salah satu perusahaan manufaktur di Bandung khususnya pada Fungsi Pengelolaan Fasilitas, mengalami kendala yaitu pada kontrol aset dan kebutuhan aplikasi. Hal ini menjadi pendorong perusahaan manufaktur tersebut untuk mengembangkan TI pada perusahaannya. Salah satu tools untuk menciptakan teknologi informasi yang sejalan dengan tujuan bisnis adalah dengan menggunakan Enterprise Architecture (EA). Melalui EA dapat memaksimalkan investasi penggunaan TI pada suatu organisasi. Pada penelitian ini, perancangan EA menggunakan framework The Open Group Architecture Framework (TOGAF ADM). Penelitian ini dilakukan pada perusahaan manufaktur di Bandung dan berfokus mulai dari fase preliminary hingga fase business architecture, pada fungsi pengelolaan fasilitas dan menggunakan framework TOGAF ADM. Penelitian ini menggunakan metode descriptive dan bertujuan untuk memberikan perancangan arsitektur bisnis sebagai solusi pada fungsi pengelolaan fasilitas untuk mengoptimalkan proses bisnisnya dan dengan menggunakan TI.
Prediction Model Kualitas Aplikasi Sistem Informasi Pembayaran Tiket (E-Ticket) Yang Dipengaruhi Oleh Budaya Organisasi Serta Dampaknya Terhadap Kualitas Informasi Akuntansi Untuk Pengambilan Keputusan
Authors: Puspitawati Lilis , Nurshalihat Novi Indriani Siti
Published: June 2021

The success of the Accounting Information System in producing quality information is the culture of the organization. Accounting Information Systems play an important role in an organization for the achievement of organizational goals that are effective and efficient. The existence of an accounting information system in an organization is nothing but to be able to produce useful information for its users in the decision making process. To be able to produce quality accounting information, we need a reliable accounting information system in processing data and transactions so that the information generated can be useful in decision making.

The method used in this research is descriptive and verification methods. Observation Unit conducted at PT. Kereta Api Indonesia (Persero) Bandung City with its analysis unit are employees in the accounting sub-division 20 people and the system 20 people. The statistical test used is the calculation of Structural Equation Modeling (SEM) with a variance-based analysis of Partial Least Square (PLS) and hypothesis testing using the help of the Smart PLS 3.0 application.

Based on the research conducted it can be seen that (1) Organizational culture significantly influences the quality of accounting information system (2) the quality of accounting information system significantly influences the quality of accounting information.
Beskrivelse til Geologisk Kort over Danmark (i Maalestok 1.: 100,000). Kortbladene Faxe og Stevns Klint. Atlas
Authors: Milthers V
Published: June 2021

Atlas med 31 tavler og 3 kort (Atlas with 31 illustrations and 3 maps)
Beskrivelse til Geologisk Kort over Danmark (i Maalestok 1:100,000). Kortbladet Bornholm. Atlas
Authors: Grönwall K.A , Milthers V
Published: June 2021

Atlas med 30 tavler og 3 kort (Atlas with 30 illustrations and 3 maps)
Beskrivelse til Geologisk Kort over Danmark (i Maalestok 1:100,000). Kortbladet Bornholm. Tekst
Authors: Grönwall K.A , Milthers V
Published: June 2021

Det geologiske Kortblad Bornholm i Maalestok 1:100,000 omfatter Øen Bornholm samt Ærtholmene.Bornholms Overfladeforhold staar i nøje Forbindelse med Karakteren af Øens prækvartære Dannelser, som i den nordlige og den centrale Del er Granit og i den sydlige og sydvestlige Del af Landet bestaar af sedimentære Aflejringer af palæozoisk og mesozoisk Alder. De mest uregelmæssige Landskabsformer findes i Granitomraadet. Hvor Graniten hyppig træder frem i Overfladen, præges denne af den ujævne, buklede Granitoverflade med de fremtrædende Rundklipper, saaledes som de er formede ved Afskuringen under Istiden. Paa de Strækninger, hvor Graniten er dækket af kvartære Aflejringer af større Mægtighed, og hvor den derfor sjældent naar frem til Overfladen, kan man finde jævnt bølgede Overfladeformer af samme Karakter som i andre Dele af Danmark, hvor det særlig er Istidens Aflejringer, der har præget Overfladens Form.