bluuebunny/crossref_metadata_2025 huggingface dataset:
Developmental Support for Infants With Genetic Disorders
Authors: Wojcik Monica H. , Stewart Jane E. , Waisbren Susan E. , Litt Jonathan S.
Published: April 2020

As the technical ability for genetic diagnosis continues to improve, an increasing number of diagnoses are made in infancy or as early as the neonatal period. Many of these diagnoses are known to be associated with developmental delay and intellectual disability, features that would not be clinically detectable at the time of diagnosis. Others may be associated with cognitive impairment, but the incidence and severity are yet to be fully described. These neonates and infants with genetic diagnoses therefore represent an emerging group of patients who are at high risk for neurodevelopmental disabilities. Although there are well-established developmental supports for high-risk infants, particularly preterm infants, after discharge from the NICU, programs specifically for infants with genetic diagnoses are rare. And although previous research has demonstrated the positive effect of early developmental interventions on outcomes among preterm infants, the impact of such supports for infants with genetic disorders who may be born term, remains to be understood. We therefore review the literature regarding existing developmental assessment and intervention approaches for children with genetic disorders, evaluating these in the context of current developmental supports postdischarge for preterm infants. Further research into the role of developmental support programs for early assessment and intervention in high-risk neonates diagnosed with rare genetic disorders is needed.
Apparent Cause Analysis: A Safety Tool
Authors: Parikh Kavita , Hochberg Evan , Cheng Jenhao Jacob , Lavette Laura Beth , Merkeley Kathryn , Fahey Lisbeth , Shah Rahul K.
Published: April 2020

Causal analysis is a core function of safety programs. Although established protocols exist for conducting root cause analysis for serious safety events, there is limited guidance for apparent cause analysis (ACA) in health care. At our institution, through a novel facilitated ACA approach, we aim to improve safety culture and provide a clear approach to address precursor safety events and near-miss safety events. We define facilitated ACA as limited investigation (scope and duration) of a safety event that resulted in little to no harm. These investigations require fewer resources and focus on preventive strategies. Our facilitated ACA model, with an operational algorithm and structured process, was developed and implemented at our tertiary-care, freestanding, urban pediatric hospital in 2018. Sixty-four ACAs were completed, and 83% were identified with the algorithm. Process measures, including time from event reporting to ACA launch (median 3 days; interquartile range 2–6 days), are tracked. Patient safety consultants averaged 5 hours to complete a facilitated ACA. A median of 3 disciplines or departments participated in each facilitated ACA. Through an iterative process, we implemented a structured process for facilitated ACA, and the model’s strength includes (1) right event, (2) right team, (3) right analysis, and (4) right action plans. This novel facilitated ACA model may support organizational cause analysis and improve safety culture with higher-reliability processes.
Morphological variation of Varroa destructor (Parasitiformes, Varroidae) in different seasons
Authors: Yevstafieva V. O. , Zaloznaya L. M. , Nazarenko O. S. , Melnychuk V. V. , Sobolta A. G.
Published: April 2020

Varroosis is one of the most dangerous and common diseases of honey bees (Apis mellifera Linnaeus, 1758) worldwide, caused by gamasid mites of the species Varroa destructor Anderson and Trueman, 2000. This external parasite is widespread and adapted to the climate conditions of most countries of the world, and it can infect bees at any life stage. It parasites on worker bees, male and queen bees, larvae and pupae, feeding on their hemolymph and fat bodies, causing lower survival rates and lower density of bee colonies, decreasing the bees’ life span. Here, we studied the specifics of the seasonal variation of female V. destructor mites, obtained from honey bees, by the morphological characters of mites belonging to the summer and winter generations, and their differences were established. Using the methods of multivariate statistics, we found significant differences between the summer (June–July) and winter (October–November) morphotypes of V. destructor mites. There are differences between the seasonal samples by 12 morphological characters of the parasite, namely the width of dorsal shield, width of dorsoventral shield, number of pores on sternal shield, length of tarsus and macrochaeta IV, and distances between setae of gnathosoma. Processing the seasonal samples of mites with discriminant analysis resulted in differences by 11 morphological characters including the length of dorsal shield, number of lancet setae, length and width of genitoventral shield, width of anal shield, number of setae and pores on sternal shield and distance between setae of gnathosoma. In general, the summer females are smaller and elongated compared to winter females, with larger genitoventral shield and shorter legs. The mites of summer and winter generations are adapted to different seasons: the summer mites to the reproductive period, the winter generation to overwintering on bees. The ratio of morphotypes in female V. destructor mites is observed to change during the year, from 20.2% winter morphotype in summer generation to 20.7% summer morphotype in winter mites. Studying the influence of acaricides on the distinguished morphotypes is a promising approach to improve pest control measures against varroosis of honey bees.
Distribution, bioecological peculiarities of staphylinids (Coleoptera, Staphylinidae) in livestock biocenoses of forest-steppe and steppe Ukraine
Authors: Palyi A. P. , Makshei A. N. , Kasianenko O. I. , Petrov R. V. , Faly L. I. , Palyi A. P.
Published: April 2020

As a result of research in the territory of livestock farms, 103 species of predatory Coleoptera were found, including Staphylinidae accounting for 51.4%, Histeridae – 27.3%, Carabidae – 21.3%. A total of 39 species of the Staphylinidae family were identified, belonging to 5 subfamilies: Oxytelinae, Steninae, Staphylininae, Tachyporinae, Aleocharinae. Species composition of staphylinids varied in relation to the types of animal rearing premises. In cowsheds and calf pens species diversity was higher (35 species). To study the peculiarities of feeding in laboratory conditions, we monitored 9 species of Staphylinidae: Philonthus addendus Sharp, Ph. cruentatus (Gmel.), Ph. rectangulus Sharp, Ph. varians (Payk.), Ph. spinipes Sharp, Ph. nitidus F., Creophilus maxillosus (L.), Ontholestes murinus (L.), Oxytelus sp. Feeding specialization of imagoes and larvae of different ages was studied. We determined that the mass of food consumed per day is higher than the weight of the beetles. Large species of staphylinids prefer feeding on average-aged larvae of flies and can eat puparia. Peculiarities of the development of coprophilous staphylinids were studied on the example of Ph. spinipes Sharp. During 24 h a female laid 1–3 eggs (in +28°С). Duration of the egg phase depends on the temperature regime (in +20 °С – 4–5, +28 °С – 3–4 days). Cessation of egg laying was observed with decrease in the temperature to +14 °С. The development takes part in three larval stages. Duration of the larva phase at +28 °С was 8–10 days, at +20 °С – 13–14 days. The first moulting was observed on the 2–3th days (in +28 °С) after the larvae emerged from the eggs. At +28 °С the pupa phase lasted 8–10 days. Decrease in temperature prolonged the rate of the development. At +24 °С it practically did not change (9–10 days), at +18 °С – increased to 13–15 days.
Temporal dynamic of the phylogenetic diversity of the bird community of agricultural lands in Ukrainian steppe drylands
Authors: Koshelev A. I. , Pakhomov O. Y. , Kunakh O. M. , Koshelev V. A. , Fedushko M. P.
Published: April 2020

This study discussed the importance of the phylogenetic components in the structure of bird communities of anthropogenically transformed ecosystems. The investigation was conducted in the landscapes of the south and south-east of Ukraine in the nesting seasons 1988–2018. The bird community in the agricultural landscape was found to be presented by 10 species. The number of species was closely correlated with its phylogenetic analogue – Faith’s index. Both indices were stationary over time, as they do not show a statistically significant time trend. The two axes were extracted as a result of the DPCOA procedure and the permutation test showed their statistical significance. The axis 1 was the most sensitive to the opposite dynamics of the abundance of Coturnix coturnix and Burhinus oedicnemus on the one hand and Alauda arvensis and Melanocorypha calandra on the other. The axis 2 is the most sensitive to the opposite dynamics of Corvus monedula and Melanocorypha calandra on the one hand and Coturnix coturnix and Motacilla flava on the other. Based on phylogenetic diversity, the years can be clustered with the extraction of four relatively homogeneous phylogenetic structures of bird communities. The indicator of the initial period of dynamics (1988–1992) was Burhinus oedicnemus. Sowing or mechanical weeding may be considered as a major factor of nest destruction of Burhinus oedicnemus. The decreasing of the abundance of the trophic recourses because of agricultural activity may have caused the monotonous negative trend over time of the Burhinus oedicnemus populations. The period 1993–2003 was a transitional one, for which there were no clear indicators, as a characteristic feature of this period was the processes of bird community restructuring. The period 2004–2013 was characterized by the loss of Burhinus oedicnemus from the community and a sharp increase in the abundance of Corvus monedula. These species are distinguished by their phylogenetic specificity and are located on the periphery relative to the phylogenetic core of the community. There was growing importance in the community of such species as Alauda arvensis, Anthus campestris, and Melanocorypha calandra between 2014 and 2018. Our results also confirm the assumption that phylogenetic overdispersion is an important requirement for the stability of the bird community in anthropogenically transformed landscapes.
Syntaxonomy and ecological differentiation of the pioneer vegetation of Ukraine. 1. Classes: Cakiletea maritimae, Ammophiletea, Crithmo-Staticetea, Crypsietea aculeatae, Therosalicornietea
Authors: Dubyna D. V. , Dziuba T. P. , Iemelianova S. M. , Makhynia L. М.
Published: April 2020

Pioneer plant communities grow on newly-formed ecotopes of coastal and partially continental areas, on patches that have dried after the surface water flooding. They are affected by sea tides, wind-induced effect, salinity, denudation, accumulation and sharp changes in soil humidity. To these factors are added chemical and biological pollution, as well as anthropogenic pressure. Due to these reasons, such plant communities have a specific floristic composition, structure, functional regime and resilience mechanisms, which are different from coenoses of more stable habitats. On the basis of the analysis of more than 600 phytosociological relevés using TWINSPAN modified algorithm the current state of littoral and halophytic classes of pioneer vegetation in Ukraine has been established and their syntaxonomic structure identified. It has been determined that the level of pioneer phytocoenoses diversity in Ukraine is similar to that of Central Europe. The Cakiletea maritimae class is presented by 1 order, 1 alliance, and 4 associations; Ammophiletea – by 1 order, 1 alliance, and 8 associations; Crithmo-Staticetea – by 1 order, 2 alliances, and 3 associations; Crypsietea aculeatae – by 1 order, 3 alliances, and 4 associations, Therosalicornietea – by 1 order, 2 alliances, and 10 associations. Synoptic tables of vegetation classes are given and nine alliances are briefly characterized. Using DCA-ordination analysis of syntaxa in the association-rank level we identified that the main factors of ecological differentiation are soil humidity and aeration as well as the nitrogen content. For the pioneer plant communities, other significant impact factors are the extremality of environmental conditions, their unevenness and non-equilibrium, in particular, the mechanical action of the sea waves, the dynamic processes of denudation and accumulation, salinity, as well as the variability of damping during the year. This research contributes to the identification of the place of the distinguished syntaxa of Ukrainian pioneer vegetation in the European system.
Floristic diversity of steppe territories near Poltava town (Ukraine)
Authors: Davydov D. A. , Gomlya L. M.
Published: April 2020

Current progress in botany requires new claims for floristic research. Now the latter is not a simple species inventory of a separate local or regional flora but it needs coordination with recent results of critical taxonomic, nomenclatural and molecular phylogenetic investigations. Based on the fact that detailed research on steppes as a zonal type of vegetation in the Forest-Steppe zone of Ukraine is very important for preservation of current steppe territories, the authors studied several territories with steppe vegetation near Poltava town (Poltava region, Ukraine). The key steppe territories found are situated near Abazivka, Rozhayivka, Kostochky, Buhayivka, Machukhy, Ivonchentsi and Zhuky villages. Data about steppe flora from only the first territory located between Abazivka and Rozhayivka villages including “Rozhayivskyi” local botanical reserve were early reported in literature sources while data about steppe vegetation of the other areas has never been published in detail. The full list of 401 vascular plant species found on these steppe territories with the frequency of distribution, major synonym names and references to current taxonomic papers for separate species are proposed. One of these species (Hemerocallis fulva (L.) L.) is a new alien for Poltava region. Taxonomy for all species was critically revised, nomenclature of several taxa (Dichoropetalum carvifolia (Vill.) Pimenov & Kljuykov, Erophila verna (L.) DC., Campanula canescens (Waldst. & Kit.) Roth) is discussed in detail. The name “Dichoropetalum carvifolium-chabraei (Crantz) Soldano et al.” is an invalid designation based on trinominal and must be rejected. The names Selinum chabraei Jacq. ex Murray, Peucedanum euphimiae Kotov and Hemerocallis lilio-asphodelus var. fulva L. were lectotypified. The studied steppe territories have the great significance in the sozological aspect, they include 32 rare steppe plant species (seven from the Red Data Book of Ukraine and 25 from the list of locally rare plants within Poltava region) so the primary task for further research is to organize their protection as the most valuable steppe areas and the monitoring of their condition in the future.
Nematicidal activity of aqueous tinctures of medicinal plants against larvae of the nematodes Strongyloides papillosus and Haemonchus contortus
Authors: Boyko O. O. , Kabar A. M. , Brygadyrenko V. V.
Published: April 2020

The study focuses on in vitro effect of aqueous tinctures of 48 species of herbaceous, shrub and tree plants on the first-third stage larvae of Strongyloides papillosus (Wedl, 1856) and third-stage larvae of Haemonchus contortus (Rudolphi, 1803) Cobb, 1898. The highest level of the effect was exerted by 3% aqueous tinctures of Wisteria sinensis (Sims) DC., Ailanthus altissima (Mill.) Swingle, Laburnum anagyroides Medik., Quercus petraea subsp. iberica (Steven ex M. Bieb.) Krassiln., Ginkgo biloba L., Colchicum autumnale L., Aristolochia manshuriensis Kom., Celastrus scandens L., Securigera varia (L.) Lassen, Magnolia kobus DC. Over 90% of the first and second non-invasive stage larvae of S. papillosus died at contact with these tinctures. The lowest parameters of LD50 were seen for L. anagyroides, Juniperus sabina L., C. scandens, M. kobus, A. manshuriensis, Wisteria sinensis (Sims) DC. and Securigera varia (L.) Lassen. Invasive larvae of S. papillosus and H. contortus were resistant to the effect of all the 48 surveyed species of plants. Third-stage larvae of H. contortus remained vital when exposed for 24 h to all the studied concentrations up to 3% aqueous tincture of plants. The results of the experiments and also the analysis of the literature indicate the necessity to continue the survey on nematocidial activity of aqueous tinctures and alcveshol extracts of plants.
La Expansión Regional de la Masonería en Nuevo León, 1905-1911
Authors: Garza Martínez Antonio
Published: April 2020

El presente trabajo pretende entender la lógica de expansión regional de la masonería en el estado de Nuevo León una vez conformada la Gran Logia del Estado de Nuevo León, que derivó en una organización del tipo de jurisdicciones territoriales de los talleres de su obediencia. Este patrón de organización se entiende como parte del uso y de la ocupación socio-espacial de la ciudad y en una escala mayor, del territorio político del estado de Nuevo León, toda vez que se comprende el contexto histórico del momento dentro del marco cronológico propuesto para este estudio.
Aluízio Pinheiro Ferreira: Maçonaria, Revolução de 30 e a criação do Território Federal do Guaporé
Authors: Ribeiro da Fonseca Dante
Published: April 2020

O artigo aborda a biografia de Aluizio Pinheiro Ferreira durante o período que vai de 1897 até 1943. Enfatiza dois aspectos da vida do biografado: sua atividade pública e sua filiação maçônic, tendo como pano de fundo principal a Revolução de 30 (1930 – 1945) e a cisão da Maçonaria Brasileira (1927). O período culmina com a criação do Território Federal do Guaporé (hoje estado brasileiro de Rondônia) em 1943, no período mais duro do governo de exceção (1937 a 1945), e a nomeação de Aluizio Ferreira como seu primeiro governador.
Francisco de Miranda ¿Iniciado masón después de muerto?
Authors: Parada José Gregorio
Published: April 2020

Mucha tinta se ha gastado para intentar abrir puentes entre la Francmasonería y el Precursor de la independencia venezolana, Francisco de Miranda. Estas líneas comienzan en Francia con un encuentro de dos grandes hombres: Miranda y Bonaparte. Ambos tienen algo en común aparte de su gran genio militar: se les suele encasillar dentro de las filas masónicas sin que haya suficientes pruebas para sustentarlo. En este artículo intentamos dar una mirada a los nexos de don Francisco de Miranda con miembros de esta hermandad, sin que por esto se le deba incluir en la lista de la afamada hermandad.
Medallas de la masonería española: El Sexenio democrático (1868-1874). Análisis documental e iconográfico
Authors: Cuadrado Merchán Manuel
Published: April 2020

Con la caída de la Monarquía Isabelina en1868 se inicia un período de libertades y la Masonería española podrá actuar dentro de la legalidad. Durante el Sexenio democrático, la Masonería experimentará una eclosión que inaugura su época dorada en España. A lo largo de los convulsos años siguientes numerosas logias españolas se integrarán en la masonería portuguesa buscando una regularidad masónica que no encontraban en las nuevas obediencias españolas. De este período se han conservado algunas medallas que documentamos y analizamos desde la numismática y la iconografía, para arrojar luz sobre esta manifestación del arte masónico español.
British Freemasonry, 1717-1813, edited by Róbert Péter
Authors: Clements Diane
Published: April 2020

Review of British Freemasonry, 1717-1813, editado por Róbert Péter. London: Routledge, 2016. 2396 pages. ISBN-13: 978-1138100190. ISBN-10: 1138100196.
Templarios y Masones. Las claves de un enigma de Javier Alvarado Planas
Authors: Morales Ruiz Juan José
Published: April 2020

Reseña de Templarios y Masones. Las claves de un enigma de Javier Alvarado Planas. Madrid: editorial Sanz y Torres, Colección Historia, 2019, 250 páginas. ISBN: 978-84-17765-94-1.
Great Horned Owl, Bubo virginianus (Gmelin, 1788) (Aves, Strigiformes), in the state of Rio de Janeiro, Brazil
Authors: Patiu Fabio de Mello , Tavares Davi Castro , Gonçalves Pablo Rodrigues
Published: April 2020

The geographic distribution of Great Horned Owl, Bubo virginianus (Gmelin, 1788), in Rio de Janeiro state, southeastern Brazil, is revised and expanded. Two individuals were recorded in an Atlantic Forest fragment surrounded by rural and industrial areas in Macaé municipality, on the northern coast of Rio de Janeiro state. This is the twentieth time that B. virginianus is documented in this state in the last two centuries and highlights the importance of bird surveys in regions with ornithological knowledge gaps.
First records of the whirligig beetles Gyretes minax Ochs, 1967 and G. puberulus Ochs, 1967 (Coleoptera, Gyrinidae) from Maranhão state, northeastern Brazil
Authors: Colpani Daniara , Desidério Gleison R. , Nascimento Stênio S.R. , Azevêdo Carlos A.S.
Published: April 2020

The genus Gyretes Brullé, 1835 has 181 species occurring in Brazil, most of them known in the country’s North Region. In this study, we record for the first time the occurrence of Gyretes minax Ochs, 1967 and Gyretes puberulus Ochs, 1967 in Maranhão state, northeastern Brazil. We also provide a diagnosis and illustrations for each of these species and comment on their geographical distributions.
INTERAKSI SIMBOLIK DAN IMAJI RELIGIOUS DALAM MEMBANGUN CITRA PONDOK PESANTREN NURUL JADID
Authors: Baharun Hasan , Intania Intania
Published: April 2020

This paper presents about the interpretation of symbols that are formed in all activities in Islamic boarding schools, where the use of these symbols has a deep meaning in religious aspects, especially in building a positive image of Islamic boarding school, until it can attract public confidence in the implementation of education and learning inside of it. The symbols formed are the creations, works, and initiatives of Islamic boarding school residents, as the basic of their social behavior and actions. This research uses a qualitative with case study, with a research site at Pondok Pesantren Nurul Jadid, Paiton, Probolinggo, East Java. The results showed that the symbols of social interaction at Islamic boarding school has own attraction. The harmony of Islamic boarding school residents in their behavior and the meaning that contained by islamic values. Syimbol which is showed through the behavior of Islamic boardin school residents is including to the part of religious image which has function as society’s aid to recognize religious life of islamic boarding school residents well, until it can be formed positive image for Islamic boarding school persistence. Hence, symbol as media to show religious image can increase positive image which is pointed to society’s trust toward education persistence at Islamic boarding school.  Tulisan ini menyajikan tentang interprestasi simbol-simbol yang terbentuk pada seluruh aktivitas yang ada di pondok pesantren, di mana penggunaan simbol tersebut memiliki makna yang mendalam dalam aspek religious, khususnya dalam membangun citra positif pesantren, sehingga mampu menarik kepercayaan masyarakat terhadap pelaksanaan pendidikan dan pembelajaran di dalamnya. Simbol yang terbentuk merupakan cipta, karya dan karsa warga pondok pesantren, sebagai basis perilaku dan tindakan sosialnya. Penelitian ini menggunakan pendekatan kualitatif jenis studi kasus, dengan situs penelitian di Pondok Pesantren Nurul Jadid, Paiton, Probolinggo, Jawa Timur. Hasil penelitian menunjukkan bahwa simbol-simbol dalam interaksi sosial pondok pesantren memiliki daya tarik sendiri. Keselarasan warga pondok pesantren dalam berperilaku melalui simbol-simbol tertentu, disebabkan karena penyesuain perilaku dengan makna yang terkandung dalam nilai-nilai Islam. Simbol yang ditampilkan melalui perilaku warga pondok pesantren, termasuk bagian dari imaji religious yang berfungsi membantu masyarakat mengenal dengan baik kehidupan religious pondok pesantren, sehingga akan membentuk citra positif bagi keberlangsungan pendidikan di pondok pesantren. Dengan demikian, simbol sebagai media untuk menunjukkan imaji regious, mampu meningkatkan citra positif pondok pesantren yang berujung pada kepercayaan masyarakat terhadap keberlangsungan pendidikan di pondok pesantren.
On modeling bodies with delaminating coatings taking into account the fields of prestresses
Authors: Bogachev I V , Vatulyan A O
Published: April 2020

The paper presents a model of steady-state oscillations of an inhomogeneous body with a prestressed exfoliating coating based on a general linearized statement of the problem of the motion of a prestressed-strained elastic body. On its basis, the statement of the problem of oscillations of an inhomogeneous strip consisting of a substrate and a prestressed coating is formulated, between which there is a delamination in a certain region. Steady oscillations are caused by a load applied to the upper boundary of the coating. To calculate the oscillations of the two-dimensional structure under consideration, the Fourier transform in the longitudinal coordinate was used and the original problem was reduced to solving a number of auxiliary boundary value problems with respect to transformants of the desired functions. From the conditions that the stress functions vanish (the cover is modeled as a mathematical section) of the substrate and the coating, the operator relations are constructed in the area of delamination to calculate the opening functions. The kernels of these operator relations are singular and are integrals over an infinite interval. A study was made of the behavior of their integrands at infinity, on the basis of which special approaches were used to calculate the kernels. As a result of solving the obtained hypersingular equations with difference kernels, for which the collocation method is used, the originals of the disclosure functions are constructed. Using a similar approach for inverting the Fourier transformations, we constructed relations to calculate the originals of the displacement functions at the upper boundary of the coverage. Based on the computational experiments, an analysis is made of the influence of the initial geometric and mechanical parameters of the substrate and coating on the values of the disclosure functions in the delamination region and the displacement functions at the upper boundary of the layer. The influence of the prestress level on the amplitude-frequency characteristics (AFC) was also investigated. It was found that the most significant effect on the frequency response is in the vicinity of the frequencies of the thick resonances. Based on the information on the displacement fields, it is possible to construct schemes for identifying delamination characteristics.
The Ultimate Load Estimation of Welded Joints of High-Strength Steels subject to Mechanical and Geometric Heterogeneity
Authors: Sapozhnikov S B , Ivanov M A , Shcherbakov I A
Published: April 2020

In this paper we consider the problems arising in the numerical estimation of the ultimate load of welded joints of high-strength steels with slight hardening. The stress concentrator in the transition node from the deposited to the base metal is modeled based on the example of welding a roller wire on a plate made of high-strength steel. The use of welding wire with a yield point lower than that of the base metal allowed to simulate areas of the welded joint with heterogeneous mechanical properties. The geometry of three areas of the welded joint is studied, i.e. weld metal, heat-affected zone (HAZ) and the base metal. Mechanical properties of all three areas are determined by calculation and experimentally. For this purpose, it is proposed to consider the material in all sections as ideally elastic-plastic, and the yield strength is uniquely associated with the hardness in the indentation zone (a Rockwell diamond cone is used). Calculations of the inelastic indentation process by the finite element method (FEM) in axis-symmetric formulation allowed obtaining a linear relationship between the hardness and the yield strength with a coefficient of 0.418. Tests at a quasi-static three-point bend (with stretching in the surfacing area) were carried out on sample beams cut perpendicular to the direction of welding. The “force-deflection” diagrams are obtained and compared with the calculated curves (FEM in a three-dimensional formulation with an explicit consideration of the complex configuration of all sections and different yield stress in the areas determined by local hardness values). There is a good agreement between the calculated and experimental ultimate loads. The proposed method of the three-stage study (determination of local hardness, yield strength in the areas and the ultimate load) can be effectively used to assess the ultimate loads of the welded joints due to the low parametricity of the proposed models of materials inelastic deformation in areas for which it is impossible to manufacture standard samples for the study of mechanical properties. The experimental study of the strengthening effect of the seam with a stress concentrator in the form of an angle of 90 degrees on the value of the ultimate bending load showed that the removal of the deposited metal does not lead to an increase in the ultimate load of the welded joint when using the welding wire of low-carbon high-plastic steel.
The Refined Model of Viscoelastic-Plastic Deformation of Reinforced Cylindrical Shells
Authors: Yankovskii A P
Published: April 2020

The paper formulates the initial-boundary-value problem of the viscoelastic-plastic bending behavior of cylindrical circular shells cross-reinforced along equidistant surfaces. The instant elastoplastic deformation of the shell composition components is described by the governing equations of the theory of plastic flow with isotropic hardening. The viscoelastic deformation of these materials is described by the defining relations of the Maxwell - Boltzmann model of body. The geometric nonlinearity of the problem is taken into account in the Karman approximation. The used system of two-dimensional resolving equations and the corresponding initial and boundary conditions make it possible to determine displacements and stress-strain state (including residual one) in materials of the composition of flexible cylindrical shells with varying degrees of accuracy. In this case, the weak resistance of the considered composite structures to transverse shears is taken into account. In the first approximation, the equations are used, the initial and boundary conditions correspond to the relations of the widely used non-classical Reddy theory. A numerical solution of the initial-boundary-value problem posed is constructed using an explicit step-by-step "cross" scheme. The elastoplastic and viscoelastic-plastic dynamic deformation of a relatively thin long circular cylindrical shell is investigated. The structure is rationally reinforced in the circumferential direction and is loaded with an internal pressure of an explosive type. It has been demonstrated that under intense short-term loading even of a relatively thin cylindrical reinforced shell by internal pressure, the traditional Reddy theory does not guarantee that the maximum residual deflection and the intensity of residual deformations of the components of the composition are accurate to within 10% compared to calculations performed by the refined theory. The difference in the results of the corresponding calculations increases with an increase in the relative thickness of the composite shell. It was found that after plastic deformation of a long reinforced cylindrical shell in its residual state, not only appear zones of edge effects, but also a local zone of an intense deformation located in the vicinity of the central section of the shell. The length of the local central zone is comparable with the length of the zones of edge effects. It is shown that the amplitude of the transverse vibrations of the reinforced shell in the vicinity of the initial moment of time significantly (by an order of magnitude) exceeds the value of the maximum modulus of the residual deflection. Therefore, the calculations performed in the framework of the theory of elastoplastic deformation of composition materials do not allow a very approximate determination of the magnitude of the residual displacements and the magnitude of the residual deformed state of the components of the composition of the cylindrical shell.
COVID-19 e saúde mental: A emergência do cuidado
Authors: Faro Andre , Bahiano Milena de Andrade , Nakano Tatiana de Cassia , Reis Catiele , Silva Brenda Fernanda Pereira da , Vitti Laís Santos
Published: April 2020

Considerando-se a situação atual mundial, marcada por importantes crises na saúde pública e, mais recentemente, a pandemia causada pela COVID-19, o presente artigo buscou reunir informações e achados de pesquisa a respeito do impacto de tais crises na saúde mental. O texto traz conceitos relacionados à problemática do novo coronavírus e analisa consequências de medidas adotadas para lidar com situações desse tipo, tais como distanciamento social, quarentena e isolamento, ao longo de três períodos distintos: pré-crise, intracrise e pós-crise. O artigo enfoca as repercussões observadas na saúde mental da população, refletindo acerca dos desfechos favoráveis e desfavoráveis dentro do processo de crise. Por fim, são apresentadas questões relacionadas a emergência do cuidado em saúde mental, tanto aquele prestado pela Psicologia, como aquele que pode ser desenvolvido pelos demais profissionais de saúde, de modo a minimizar os impactos negativos da crise e atuar de modo preventivo.
Fostering resilience-oriented thinking in engineering practice
Authors: MacAskill Kristen , O’Hanlon Francesca , Guthrie Peter , Mian Juliet
Published: April 2020

Round tables discussing the resilience of critical infrastructure systems held in the UK, the USA and New Zealand have provided insight into how organisations are changing the basis of planning and investment decisions to enhance resilience. The events convened stakeholders to explore how resilience is embraced in their sectors and to identify how to advance practice. The overarching premise was to convene a diverse group who would not typically have an opportunity to engage with each other, to share their perspectives on putting resilience thinking into practice. The round tables identified that early-adopting organisations are implementing approaches to decision making that embrace resilience thinking, but such approaches are not yet embedded in common practice across organisations that are responsible for planning and managing critical infrastructure. The findings emphasise that multi-agency coordination and collaboration is required to advance resilience thinking in professional practice and to move beyond traditional risk-based paradigms. Governance and policy interventions will help encourage cross-sector information sharing and enforce responsibility and transparency surrounding exposure to potential shocks and stresses. It is recommended that such interventions could expand on principles and practice in existing emergency-management efforts, on the basis that such efforts are founded on coordinating various groups.
Characteristics of Psychiatry Consultations Requested from the Neurology Clinic, Diagnostic Congruence Rates between Psychiatrists and Neurologists
Authors: ERDOGAN Esin , DELİBAŞ Dursun Hakan , EŞKUT Neslihan
Published: April 2020

Amaç: Psikiyatri ve nöroloji merkezi sinir sistemine ait işlev bozukluklarıyla ilgilenmeleri nedeniyle ilgili hastalıklara yönelik ortak yaklaşım gerekmektedir. Bu araştırmada bir eğitim hastanesinin nöroloji kliniğinde yatarak tedavi gören hastalara istenen psikiyatri konsültasyonlarının özellikleri, psikiyatrik hastalıkların tanı benzerlik oranları ve psikiyatri hekimi ile nöroloji hekimi arasındaki psikiyatrik tanı uyumunun araştırılması amaçlanmıştır.
Gereç ve Yöntem: Ocak 2017-Temmuz 2019 tarihleri arasında istenen tüm psikiyatri konsültasyonları geriye dönük olarak değerlendirilmiş, konsültan psikiyatristin belirlediği son psikiyatrik tanı ile nöroloğun belirlediği ilk psikiyatrik tanı arasındaki doğruluk oranı ve iki branş arasındaki tanı uyumu incelenmiştir.
Bulgular: En sık konsültasyon istenme nedenleri sırasıyla ajitasyon (%36.5), depresyon belirtileri (%23.9) ve geçmişte psikiyatrik tedavi öyküsü (%18.9) olarak bulunmuştur. Psikiyatristler tarafından en sık konulan tanılar depresif bozukluklar (%29.7), anksiyete bozuklukları (%19.8) ve kognitif bozukluklardır (%10.9). Doğru tanınma oranları alkol/madde kullanım bozuklukları (A/MKB) (%83.3) ve kognitif bozukluklar (%73.7) için yüksek saptanırken, somatizasyon bozukluğu (%50) ve anksiyete bozuklukları (%29.2) için düşük saptanmıştır. A/MKB için iki hekim arasındaki tanı uyumu yüksek (kappa=0.62), kognitif bozukluklar ve depresif bozukluklar için orta düzeydedir (kappa=0.57, kappa=0.42).
Sonuç: Bu çalışma A/MKB’nun nörologlar tarafından iyi tanındığını, ancak yatan hastalarda sıklıkla görülen anksiyete bozukluğu ve somatizasyon bozukluğunun tanısında yanılgıların yaşandığını göstermiştir. Bu alanda yapılan araştırma sayısının az olması nedeniyle araştırmamız nörolojik hasta popülasyonunda psikiyatrik eş tanıların tanınmasının önemini vurgulaması açısından değerlidir.
Transferencia tecnológica para la producción limpia en la minería de materiales aluviales en La Guajira, Colombia
Authors: Polo Bornachera Kevin , López Juvinao Danny Daniel , Henríquez Jaramillo Alfonso
Published: April 2020

Objetivo: Analizar la transferencia tecnológica para la producción limpia en la minería de materiales aluviales en La Guajira, Colombia.  Metodología: La investigación fue de tipo descriptiva, con diseño no experimental, transeccional y de campo. La población estuvo conformada por tres empresas: Agregados Río Negro, Valores y Contratos S.A. “Valorcon S.A.” y La Macuira Inversiones y Construcciones S.A, que conforman el sector de la minería de materiales aluviales en La Guajira. Para la recolección de datos se utilizó como técnica la encuesta, empleándose como instrumento dirigido a los informantes, con preguntas cerradas y cinco alternativas de respuesta, constituido por 49 ítems. Se aplicó la validez de criterio con expertos, luego se realizó el cálculo de la confiabilidad a través del coeficiente Alfa de Cronbach, obteniéndose un valor de 0,90. Resultados: Se encontró que la mayor parte de la población realiza la transferencia directamente con el proveedor de la tecnología, es decir solo intervienen un receptor y quien provee, la población estudiada a veces asiste a ferias y congresos para obtener información sobre nuevas tecnologías, y entre las barreras se destaca que gran parte de la población no utiliza tecnologías adecuadas para la producción limpia. Conclusiones: La transferencia de tecnología en las empresas estudiadas estuvo enmarcada por  las carencias de tecnologías que propicien una producción limpia, el factor competitivo de la tecnología y aumento de la calidad de los proyectos.
Overviews on adverse events in pharmacological interventions v1
Authors: Dorando Elena
Published: April 2020

Please find detailed information on our protocol in the attached PDF file.
illumina MiSeq Dual Index Amplicon Sequencing Sample Preparation Bacterial 16S rRNA gene v1
Authors: Eiler Alexander , Osman Omneya
Published: April 2020

Preparation of PCR products for amplicon sequencing
Expression of growth factors and tyrosine kinase receptors in the primary tumor and tumor thrombus cells in patients with renal cell carcinoma
Authors: Volkova M. I. , Olshanskaya A. S. , Tsimafeyeu I. V. , Vashakmadze N. L. , Khochenkova Yu. A. , Solomko E. Sh. , Ashuba S. A. , Khochenkov D. A. , Matveev V. B.
Published: April 2020

Objective: to assess the expression and prognostic value of vascular endothelial growth factor A (VEGF-A), fibroblast growth factor 2 (FGF-2) and their receptors VEGFR-1, -2; FGFR-1, -2, as well as platelet-derived growth factor receptors (PDGFR-α, PDGFR-β) in paired samples of primary tumors and tumor thrombi in renal cell carcinoma (RCC).

Materials and methods. Expression of VEGF-A, FGF-2, VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β was studied in paired surgical samples of primary tumors and tumor thrombi in 25 patients with clear cell RCC pT3a–T4N0–1M0–1 and tumor venous thrombosis by immunohistochemical assay using the appropriate Abcam/Santa Cruz Biotech antibodies from the immunohistochemical staining kit Invitrogen. Expression levels were evaluated by a semi-quantitative method (H-score). The analysis of the correlation between expression levels of VEGF-A, FGF-2, VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β and RCC characteristics, as well as evaluation of their influence on the outcome of RCC were performed.

Results. VEGF-A, FGF-2, as well as VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β were expressed in the cytoplasm and on the membrane of the primary tumor and tumor thrombus cells in RCC patients. Tumor thrombus cells were characterized by lower expression of VEGFR-1, VEGFR-2, PDGFR-α (p <0.05 for all) and tendency to lower expression of VEGF-A (p = 0.060), FGF-2 (p = 0.046), FGFR-1 (p = 0.077) and FGFR-2 (p = 0.090) compared with primary tumor cells. RCC Furman grade correlated with the expression levels of VEGFR-1 (p = 0.035) and FGFR-1 (p = 0.022) in the primary tumor cells, tumor invasion into venous wall correlated with the expression levels of VEGFR-1 (p = 0.023) and FGFR-2 (p = 0.005) on the thrombus cells. VEGFR-2 overexpression in the primary tumor cells was associated with significant decrease of overall survival (OS) rate (p = 0.011). There was a tendency to OS deterioration in cases with overexpression of VEGFR-2 (p = 0.093) and VEGF-A (p = 0.095) in the tumor thrombus cells. One-year OS in patients with ³2 identified risk factors was 27.3 %, <2 risk factors – 87.5 % (p = 0.004).

Conclusion. Tumor thrombus cells in RCC patients expressed VEGF-A, FGF-2, VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β less active than the cells of the primary tumor. Overexpression of growth factors and tyrosine kinases correlated with RCC Furman grade and tumor venous wall invasion. Overexpression of VEGFR-2 in both primary tumor and thrombus cells in combination with hypoexpression of VEGF-A in the thrombus negatively influenced on OS.
Oncological results of neoadjuvant chemohormonal therapy in patients with high and very high-risk prostate cancer
Authors: Berkut M. V. , Artemjeva A. S. , Reva S. A. , Tolmachev S. S. , Petrov S. B. , Nosov A. K.
Published: April 2020

TolsotogoSt., Saint Petersburg 197022, Russia

Background.Prostate cancer (PCa) of a high and very high risk is a potentially fatal disease that requires an active multimodal approach, including the use of neoadjuvant drug treatment. As option for this treatment is neoadjuvant chemohormonal therapy (NCHT) followed by radical prostatectomy (RPE). However, data on the oncological results of treatment of such patients are still limited and the role of neoadjuvant therapy in the treatment of high and very high-risk PCa remains not fully understood.

Objective:toassesstheoncologicalresultsoftreatmentpatientswithlocalizedandlocallyadvancedPCaofhighandveryhighriskafterNCHT.

Materials and methods.This was a prospective randomized study: patients with PCa of high and very high-risk groups (prostate specific antigen levels (PSA) >20 ng/ml and/or Gleason score³8and/or clinical stage >T2c) were treated with RPE only (group RPE; n = 35) or NCHT followed by RPE (NCHT/RPE group; n = 36). The neoadjuvant course included the intravenous administration of docetaxel once every 21 days (75 mg/m2 up to 6 cycles) and the antagonist of the gonadotropin releasing hormone degarelix according to the standard scheme (6 subcutaneous injections every 28 days). After a follow-up examination evaluating the result of the neoadjuvant regimen, patients underwent RPE with extanded lymphadenectomy.

Results.A mean follow-up was 37.08 ± 20.46 months. A statistically significant reduction of prostate specific antigen >50 % post-chemohormonal therapy was observed in all 36 cases. Lower postoperative stage was noticed in 38.5 % in NCHT/RPE group compared with 2.7 % in RPE group. Similarly, positive surgical margin rate was higher in group without neoadjuvant therapy – 40 and 25 % (RPE group). Cancerspecific survival was 97.2 % in NCHT/RPE group and 87.56 % in the RP group (p = 0.037), cancer specific survival rate – 91.4 % and97.2 % respectively (log-rank test p = 0.22). At the same time, no statistically significant differences were obtained in 3-year recurrence free survival between groups: 38.8 % in NCHT/RPE group versus 43.6 % in the RPE group (log-rank test p = 0.36).

Conclusion.Conducting NCHT before RPE is a safe and effective strategy in patients with PCa of high and very high risk groups and could improve oncological results.
Early complications of radical cystectomy with various types of urine diversion: prognostic factors analysis
Authors: Musayev T. N.
Published: April 2020

Objective: to analyze factors predicting complications in a series of radical cystectomies (RCs) performed for bladder cancer over a 10-year period at the National Center of Oncology (Baku).

Materials and methods. From July 2008 to December 2017 we retrospectively selected 257 consecutive cases of RC with pelvic lymphadenectomy and various options of urine diversion for bladder malignant neoplasms. Information on preoperative prognostic factors, including demographic parameters, as well as general patient health parameters, tumor characteristics and factors concerning the operation was obtained from medical records. We analyzed perioperative factors using monovariant logistic regression, where the endpoints were development of any complication (I–V degrees according to Clavien–Dindo classification), as well as severe complication (III–V grades) within 30-days after RC were considered the endpoints. After the missing data on preoperative bacteriological urinalysis were multiply imputed, a multivariate logistic regression has been performed with odds ratio (OR) calculation.

Results. During the 30-day period, complications were registered in 111 (43.2 %) patients, severe complications – in 48 (18.7 %). Multivariate analysis revealed the following independent predictors of any postoperative complications after RC: local cT4 tumor extension (OR 4.52; p = 0.002), age (OR 1.87; p = 0.017), positive bacteriological urine analysis (OR 2.16; p = 0.032) and number of performed RCs (OR 0.89; p = 0.038). Severe postoperative complications were associated with positive urine culture (OR 4.05; p = 0.002) and age (OR 2.44; p = 0.013).

Conclusion. Our study revealed the following independent factors, which were significantly associated with the risk of any complication or severe complication after RC: local cT4 tumor extension, age, positive urine bacteriological analysis before the intervention and a small number of surgeries or positive urine culture and age, respectively.