bluuebunny/crossref_metadata_2025 huggingface dataset:
Impregnation of Activated Carbon with Organic Phase-Change Material
Authors: Bae Jiyeol , Kim Suho , Kim Kwangsoo , Baek Soyoung
Published: December 2023

In this study, we developed a thermal storage medium comprising porous activated carbon filled with organic phase-change materials (PCMs) that utilizes the latent heat of phase-change to absorb heat during heating and release heat during cooling. For the activated carbon, we used both charcoal-based powdered activated carbon (250–350 mesh) and granular activated carbon. The organic phase-change materials used in the experiments were dodecane, tridecane, tetradecane, and pentadecane. Material properties such as thermal conductivity, latent heat, and melting temperature range were evaluated experimentally and theoretically, with the results observed to be consistent. The cyclic thermal performance of the proposed medium was also evaluated. Notably, filling the activated carbon with a mixture of organic PCMs resulted in the highest temperature-moderating effect. The procedure and results presented in this study are expected to aid in further improvement in the performance of thermal storage media containing PCM where stable temperatures are required, including building heating and cooling.
Development and Future Trends of Protective Strategies for Magnesium Alloy Vascular Stents
Authors: Liu Dexiao , Yang Ke , Chen Shanshan
Published: December 2023

Magnesium alloy stents have been extensively studied in the field of biodegradable metal stents due to their exceptional biocompatibility, biodegradability and excellent biomechanical properties. Nevertheless, the specific in vivo service environment causes magnesium alloy stents to degrade rapidly and fail to provide sufficient support for a certain time. Compared to previous reviews, this paper focuses on presenting an overview of the development history, the key issues, mechanistic analysis, traditional protection strategies and new directions and protection strategies for magnesium alloy stents. Alloying, optimizing stent design and preparing coatings have improved the corrosion resistance of magnesium alloy stents. Based on the corrosion mechanism of magnesium alloy stents, as well as their deformation during use and environmental characteristics, we present some novel strategies aimed at reducing the degradation rate of magnesium alloys and enhancing the comprehensive performance of magnesium alloy stents. These strategies include adapting coatings for the deformation of the stents, preparing rapid endothelialization coatings to enhance the service environment of the stents, and constructing coatings with self-healing functions. It is hoped that this review can help readers understand the development of magnesium alloy cardiovascular stents and solve the problems related to magnesium alloy stents in clinical applications at the early implantation stage.
Optimization of the Voltage Total Harmonic Distortion in Multilevel Inverters by Using the Taguchi Method
Authors: Lopez Adolfo R. , Sosa José M. , Sámano Cristian , De León-Aldaco Susana Estefany , Aguayo-Alquicira Jesus , López-Santos Oswaldo
Published: December 2023

A critical reduction in the total harmonic distortion in the output voltage of multilevel inverters can be obtained with an appropriate selection of the angles to switch the power semiconductors at low frequency. Among the methods used to obtain the required sequence of angles, it is possible to recognize both standard and optimized methods, like the Newton–Raphson method or the genetic algorithm, to mention a few. However, implementing the genetic algorithm implies using several configuration parameters, so it is difficult to know if the best option was chosen. This paper implements the Taguchi design of experiments, the Taguchi method, to obtain the appropriate switching angles for an multilevel inverter producing an output voltage of five and seven levels. Experimental results obtained from a laboratory prototype using the computed angles in the MATLAB GA solver demonstrate the superiority of the proposed method.
Discounted Risk-Sensitive Optimal Control of Switching Diffusions: Viscosity Solution and Numerical Approximation
Authors: Lu Xianggang , Sun Lin
Published: December 2023

This work considers the infinite horizon discounted risk-sensitive optimal control problem for the switching diffusions with a compact control space and controlled through the drift; thus, the the generator of the switching diffusions also depends on the controls. Note that the running cost of interest can be unbounded, so a decent estimation on the value function is obtained, under suitable conditions. To solve such a risk-sensitive optimal control problem, we adopt the viscosity solution methods and propose a numerical approximation scheme. We can verify that the value function of the optimal control problem solves the optimality equation as the unique viscosity solution. The optimality equation is also called the Hamilton–Jacobi–Bellman (HJB) equation, which is a second-order partial differential equation (PDE). Since, the explicit solutions to such PDEs are usually difficult to obtain, the finite difference approximation scheme is derived to approximate the value function. As a byproduct, the ϵ-optimal control of finite difference type is also obtained.
Multi-Material Radial Phononic Crystals to Improve the Quality Factor of Piezoelectric MEMS Resonators
Authors: Yang Qian , Gao Tianhang , Zhu Chuang , Li Lixia
Published: December 2023

In this paper, a multi-material radial phononic crystal (M-RPC) structure is proposed to reduce the anchor-point loss of piezoelectric micro-electro-mechanical system (MEMS) resonators and improve their quality factor. Compared with single-material phononic crystal structures, an M-RPC structure can reduce the strength damage at the anchor point of a resonator due to the etching of the substrate. The dispersion curve and frequency transmission response of the M-RPC structure were calculated by applying the finite element method, and it was shown that the M-RPC structure was more likely to produce a band-gap range with strong attenuation compared with a single-material radial phononic crystal (S-RPC) structure. Then, the effects of different metal–silicon combinations on the band gap of the M-RPC structures were studied, and we found that the largest band-gap range was produced by a Pt and Si combination, and the range was 84.1–118.3 MHz. Finally, the M-RPC structure was applied to a piezoelectric MEMS resonator. The results showed that the anchor quality factor of the M-RPC resonator was increased by 33.5 times compared with a conventional resonator, and the insertion loss was reduced by 53.6%. In addition, the loaded and unloaded quality factors of the M-RPC resonator were improved by 75.7% and 235.0%, respectively, and at the same time, there was no effect on the electromechanical coupling coefficient.
Materials, Designs, and Implementations of Wearable Antennas and Circuits for Biomedical Applications: A Review
Authors: Yang Minye , Ye Zhilu , Ren Yichong , Farhat Mohamed , Chen Pai-Yen
Published: December 2023

The intersection of biomedicine and radio frequency (RF) engineering has fundamentally transformed self-health monitoring by leveraging soft and wearable electronic devices. This paradigm shift presents a critical challenge, requiring these devices and systems to possess exceptional flexibility, biocompatibility, and functionality. To meet these requirements, traditional electronic systems, such as sensors and antennas made from rigid and bulky materials, must be adapted through material science and schematic design. Notably, in recent years, extensive research efforts have focused on this field, and this review article will concentrate on recent advancements. We will explore the traditional/emerging materials for highly flexible and electrically efficient wearable electronics, followed by systematic designs for improved functionality and performance. Additionally, we will briefly overview several remarkable applications of wearable electronics in biomedical sensing. Finally, we provide an outlook on potential future directions in this developing area.
Salmonella Typhimurium with Eight Tandem Copies of blaNDM-1 on a HI2 Plasmid
Authors: Song Huijuan , Zou Siyu , Huang Yi , Jian Cui , Liu Weiyong , Tian Lei , Gong Lu , Chen Zhongju , Sun Ziyong , Wang Yue
Published: December 2023

Carbapenem-resistant Salmonella has recently aroused increasing attention. In this study, a total of four sequence type 36 Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) isolates were consecutively isolated from an 11-month-old female patient with a gastrointestinal infection, of which one was sensitive to carbapenems and three were resistant to carbapenems. Via antibiotic susceptibility testing, a carbapenemases screening test, plasmid conjugation experiments, Illumina short-reads, and PacBio HiFi sequencing, we found that all four S. Typhimurium isolates contained a blaCTX-M-14-positive IncI1 plasmid. One carbapenem-sensitive S. Typhimurium isolate then obtained an IncHI2 plasmid carrying blaNDM-1 and an IncP plasmid without any resistance genes during the disease progression. The blaNDM-1 gene was located on a new 30 kb multiple drug resistance region, which is flanked by IS26 and TnAs2, respectively. In addition, the ST_F0903R isolate contained eight tandem copies of the ISCR1 unit (ISCR1-dsbD-trpF-ble-blaNDM-1-ISAba125Δ1), but an increase in MICs to carbapenems was not observed. Our work further provided evidence of the rapid spread and amplification of blaNDM-1 through plasmid. Prompting the recognition of carbapenem-resistant Enterobacterales and the initiation of appropriate infection control measures are essential to avoid the spread of these organisms.
Competitive Analysis of Rumen and Hindgut Microbiota Composition and Fermentation Function in Diarrheic and Non-Diarrheic Postpartum Dairy Cows
Authors: Hao Yangyi , Ouyang Tong , Wang Wei , Wang Yajing , Cao Zhijun , Yang Hongjian , Guan Le Luo , Li Shengli
Published: December 2023

Postpartum dairy cows can develop nutritional diarrhea when their diet is abruptly changed for milk production. However, it is unclear whether nutritional diarrhea develops as a result of gut acidosis and/or dysbiosis. This study aimed to uncover changes in the gastrointestinal microbiota and its fermentation parameters in response to nutritional diarrhea in postpartum dairy cows. Rumen and fecal samples were collected from twenty-four postpartum cows fed with the same diet but with different fecal scores: the low-fecal-score (LFS: diarrheic) group and high-fecal-score (HFS: non-diarrheic) group. A microbiota difference was only observed for fecal microbiota, with the relative abundance of Defluviitaleaceae_UCG-011 and Lachnospiraceae_UCG-001 tending (p < 0.10) to be higher in HFS cows compared to LFS cows, and Frisingicoccus were only detected in HFS cows. The fecal bacterial community in LFS cows had higher robustness (p < 0.05) compared to that in HFS cows, and also had lower negative cohesion (less competitive behaviors) and higher positive cohesion (more cooperative behaviors) (p < 0.05) compared that in to HFS cows. Lower total volatile fatty acids and higher ammonia nitrogen (p < 0.05) were observed in LFS cows’ feces compared to HFS cows. The observed shift in fecal bacterial composition, community networks, and metabolites suggests that hindgut dysbiosis could be related to nutritional diarrhea in postpartum cows.
Microbiome in Cancer Development and Treatment
Authors: Ciernikova Sona , Sevcikova Aneta , Mladosievicova Beata , Mego Michal
Published: December 2023

Targeting the microbiome, microbiota-derived metabolites, and related pathways represents a significant challenge in oncology. Microbiome analyses have confirmed the negative impact of cancer treatment on gut homeostasis, resulting in acute dysbiosis and severe complications, including massive inflammatory immune response, mucosal barrier disruption, and bacterial translocation across the gut epithelium. Moreover, recent studies revealed the relationship between an imbalance in the gut microbiome and treatment-related toxicity. In this review, we provide current insights into the role of the microbiome in tumor development and the impact of gut and tumor microbiomes on chemo- and immunotherapy efficacy, as well as treatment-induced late effects, including cognitive impairment and cardiotoxicity. As discussed, microbiota modulation via probiotic supplementation and fecal microbiota transplantation represents a new trend in cancer patient care, aiming to increase bacterial diversity, alleviate acute and long-term treatment-induced toxicity, and improve the response to various treatment modalities. However, a more detailed understanding of the complex relationship between the microbiome and host can significantly contribute to integrating a microbiome-based approach into clinical practice. Determination of causal correlations might lead to the identification of clinically relevant diagnostic and prognostic microbial biomarkers. Notably, restoration of intestinal homeostasis could contribute to optimizing treatment efficacy and improving cancer patient outcomes.
Zagamiite, CaAl2Si3.5O11, the Hexagonal High-Pressure CAS Phase with Dominant Si, as a Mineral from Mars
Authors: Ma Chi , Tschauner Oliver , Beckett John R. , Greenberg Eran , Prakapenka Vitali B.
Published: December 2023

Within the Ca-Al-silicate system, dense, layered hexagonal phases occur at high temperatures and pressures between 20 and 23 GPa. They have been observed both in nature and in experiments. In this study, we describe the endmember with a dominant sixfold coordinated Si as a mineral zagamiite (IMA 2015-022a). This new mineral identified in Martian meteorites has a general formula of (Ca,Na)(Al,Fe,Mg)2(Si,Al,□)4O11, thus defining CaAl2Si3.5O11 as a previously unknown endmember of the hexagonal CAS phases. Zagamiite assumes space group P63/mmc with a unit cell of a = 5.403(2) Å, c = 12.77(3) Å, V = 322.9(11) Å3, and Z = 2. Zagamiite contains significant Fe and Mg and a substantial deficit of Na relative to plagioclase of an equivalent Al/Si, suggesting that it was formed through crystallization from a melt that was derived from a plagioclase-dominant mixture of plagioclase and clinopyroxene above the solidus beyond 20 GPa.
Rapid Screening of Phenolic Compounds with Anti-Enteritis Activity from Camellia oleifera Oil Using a Smurf Drosophila Model and Molecular Docking Methods
Authors: Wang Shuhao , Li Yang , Lin Xin , Fu Xiangjin , Zhong Haiyan , Ren Kangzi , Liu Cheng , Yao Wen
Published: December 2023

Screening and identifying the active compounds in foods are important for the development and utilization of functional foods. In this study, the anti-enteritis activity of ethanol extract from Camellia oleifera oil (PECS) was quickly evaluated using a Smurf Drosophila model and the metabolomics approach, combined with molecular docking techniques, were performed to rapidly screen and identify compounds with potential anti-enteritis activity in PECS. PECS showed good anti-enteritis activity and inhibited the activity of 5-lipoxygenase (LOX), cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS). In particular, wighteone and p-octopamine were newly identified in C. oleifera oil and were proven to have good anti-enteritis activity. The inhibitory activity of kaempferitrin (IC50 = 0.365 mmol L−1) was higher than that of wighteone (IC50 = 0.424 mmol L−1) and p-octopamine (IC50 = 0.402 mmol L−1). Of note, the IC50 value of salazosulfapyridine was 0.810 mmol L−1. Inhibition of LOX activity is likely one of the anti-enteritis mechanisms of PECS. These new findings lay the foundation for further investigations into the underlying mechanisms of anti-enteritis activity in C. oleifera oil.
Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors in Phyllanthus acuminatus Hairy Roots by Non-Targeted Analysis Using High-Resolution Mass Spectrometry
Authors: Benavides Katherine , Sánchez-Kopper Andrés , Jiménez-Quesada Karol , Perez Raquel , Garro-Monge Giovanni
Published: December 2023

Phyllanthus acuminatus has been studied for its vast medical and industrial potential. Phytochemical investigations reveal that the genus is a rich source of lignans, flavonoids, phenolics, terpenoids, and other metabolites. However, the phytochemical profile elucidation of this species still needs further research. The use of eliciting compounds such as salicylic acid and methyl jasmonate has managed to increase the production of secondary metabolites in plant cell cultures. Hairy roots of Phyllanthus acuminatus were produced in 250 mL flasks with a 16 h light/8 h darkness photoperiod under diffused light with a culture time of four weeks. The elicitors salicylic acid and methyl jasmonate were tested in 50 μM and 200 μM concentrations. Non-targeted analysis was done for the different treatments using HR-MS. Identified metabolites were grouped in phenylpropanoids, phenols, and mucic acids, and statistical analysis of relative concentrations was achieved. A significant change in phenols’ relative concentrations appeared in the elicitations with salicylic acid. Because of the elicitation treatment, specific compounds increased their concentrations, some of which have known pharmacological effects and are used in treating chronic diseases. The best elicitation treatment was salicylic acid 50 μM as it increased by more than 100% the general content of phenols and phenylpropanoid derivates and triplicates the concentration of mucic acid derivates in treated hairy root extracts. The application of non-targeted analysis showed interesting changes in phytochemical concentration due to elicitation in Phyllanthus acuminatus hairy roots.
Discovery of a 4-Hydroxy-3′-Trifluoromethoxy-Substituted Resveratrol Derivative as an Anti-Aging Agent
Authors: Liang Yinhu , Chen Xi , Teng Zhifeng , Wang Xuekun , Yang Jie , Liu Guoyun
Published: December 2023

With the intensification of population aging, aging-related diseases are attracting more and more attention, thus, the study of aging mechanisms and anti-aging drugs is becoming increasingly urgent. Resveratrol is a potential candidate as an anti-aging agent, but its low bioavailability limits its application in vivo. In this work, a 4-hydroxy-3′-trifluoromethoxy-substituted resveratrol derivative (4–6), owing to its superior cell accumulation, could inhibit NO production in an inflammatory cell model, inhibit oxidative cytotoxicity, and reduce ROS accumulation and the population of apoptotic cells in an oxidative stress cell model. In D-galactose (D-gal)-stimulated aging mice, 4–6 could reverse liver and kidney damage; protect the serum, brain, and liver against oxidative stress; and increase the body’s immunity in the spleen. Further D-gal-induced brain aging studies showed that 4–6 could improve the pathological changes in the hippocampus and the dysfunction of the cholinergic system. Moreover, protein expression related to aging, oxidative stress, and apoptosis in the brain tissue homogenate measured via Western blotting also showed that 4–6 could ameliorate brain aging by protecting against oxidative stress and reducing apoptosis. This work revealed that meta-trifluoromethoxy substituted 4–6 deserved to be further investigated as an effective anti-aging candidate drug.
Impact of Surface Trap States on Electron and Energy Transfer in CdSe Quantum Dots Studied by Femtosecond Transient Absorption Spectroscopy
Authors: Dou Hongbin , Yuan Chunze , Zhu Ruixue , Li Lin , Zhang Jihao , Weng Tsu-Chien
Published: December 2023

The presence of surface trap states (STSs) is one of the key factors to affect the electronic and optical properties of quantum dots (QDs), however, the exact mechanism of how STSs influence QDs remains unclear. Herein, we demonstrated the impact of STSs on electron transfer in CdSe QDs and triplet-triplet energy transfer (TTET) from CdSe to surface acceptor using femtosecond transient absorption spectroscopy. Three types of colloidal CdSe QDs, each containing various degrees of STSs as evidenced by photoluminescence and X-ray photoelectron spectroscopy, were employed. Time-resolved emission and transient absorption spectra revealed that STSs can suppress band-edge emission effectively, resulting in a remarkable decrease in the lifetime of photoelectrons in QDs from 17.1 ns to 4.9 ns. Moreover, the investigation of TTET process revealed that STSs can suppress the generation of triplet exciton and effectively inhibit band-edge emission, leading to a significant decrease in TTET from CdSe QDs to the surface acceptor. This work presented evidence for STSs influence in shaping the optoelectronic properties of QDs, making it a valuable point of reference for understanding and manipulating STSs in diverse QDs-based optoelectronic applications involving electron and energy transfer.
Observation of Multi-Phonon Emission in Monolayer WS2 on Various Substrates
Authors: Adler Eli R. , Le Thy Doan Mai , Boulares Ibrahim , Boyd Robert , He Yangchen , Rhodes Daniel , Van Keuren Edward , Barbara Paola , Najmaei Sina
Published: December 2023

Transition metal dichalcogenides (TMDs) have unique absorption and emission properties that stem from their large excitonic binding energies, reduced-dielectric screening, and strong spin–orbit coupling. However, the role of substrates, phonons, and material defects in the excitonic scattering processes remains elusive. In tungsten-based TMDs, it is known that the excitons formed from electrons in the lower-energy conduction bands are dark in nature, whereas low-energy emissions in the photoluminescence spectrum have been linked to the brightening of these transitions, either via defect scattering or via phonon scattering with first-order phonon replicas. Through temperature and incident-power-dependent studies of WS2 grown by CVD or exfoliated from high-purity bulk crystal on different substrates, we demonstrate that the strong exciton–phonon coupling yields brightening of dark transitions up to sixth-order phonon replicas. We discuss the critical role of defects in the brightening pathways of dark excitons and their phonon replicas, and we elucidate that these emissions are intrinsic to the material and independent of substrate, encapsulation, growth method, and transfer approach.
Lead-Free Perovskite Thin Films for Gas Sensing through Surface Acoustic Wave Device Detection
Authors: Enea Nicoleta , Ion Valentin , Viespe Cristian , Constantinoiu Izabela , Bonciu Anca , Stîngescu Maria Luiza , Bîrjega Ruxandra , Scarisoreanu Nicu Doinel
Published: December 2023

Thin film technology shows great promise in fabricating electronic devices such as gas sensors. Here, we report the fabrication of surface acoustic wave (SAW) sensors based on thin films of (1 − x) Ba(Ti0.8Zr0.2)O3−x(Ba0.7Ca0.3)TiO3 (BCTZ50, x = 50) and Polyethylenimine (PEI). The layers were deposited by two laser-based techniques, namely pulsed laser deposition (PLD) for the lead-free material and matrix assisted pulsed laser evaporation (MAPLE) for the sensitive polymer. In order to assay the impact of the thickness, the number of laser pulses was varied, leading to thicknesses between 50 and 350 nm. The influence of BCTZ film’s crystallographic features on the characteristics and performance of the SAW device was studied by employing substrates with different crystal structures, more precisely cubic Strontium Titanate (SrTiO3) and orthorhombic Gadolinium Scandium Oxide (GdScO3). The SAW sensors were further integrated into a testing system to evaluate the response of the BCTZ thin films with PEI, and then subjected to tests for N2, CO2 and O2 gases. The influence of the MAPLE’s deposited PEI layer on the overall performance was demonstrated. For the SAW sensors based on BCTZ/GdScO3 thin films with a PEI polymer, a maximum frequency shift of 39.5 kHz has been obtained for CO2; eight times higher compared to the sensor without the polymeric layer.
Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System
Authors: Pai Christopher , Sengupta Rajarshi , Heuckeroth Robert O.
Published: December 2023

The enteric nervous system (ENS) is an essential network of neurons and glia in the bowel wall. Defects in ENS development can result in Hirschsprung disease (HSCR), a life-threatening condition characterized by severe constipation, abdominal distention, bilious vomiting, and failure to thrive. A growing body of literature connects HSCR to alterations in miRNA expression, but there are limited data on the normal miRNA landscape in the developing ENS. We sequenced small RNAs (smRNA-seq) and messenger RNAs (mRNA-seq) from ENS precursor cells of mid-gestation Ednrb-EGFP mice and compared them to aggregated RNA from all other cells in the developing bowel. Our smRNA-seq results identified 73 miRNAs that were significantly enriched and highly expressed in the developing ENS, with miR-9, miR-27b, miR-124, miR-137, and miR-488 as our top 5 miRNAs that are conserved in humans. However, contrary to prior reports, our follow-up analyses of miR-137 showed that loss of Mir137 in Nestin-cre, Wnt1-cre, Sox10-cre, or Baf53b-cre lineage cells had no effect on mouse survival or ENS development. Our data provide important context for future studies of miRNAs in HSCR and other ENS diseases and highlight open questions about facility-specific factors in development.
Phantosmia in Parkinson’s Disease: A Systematic Review of the Phenomenology of Olfactory Hallucinations
Authors: Ercoli Tommaso , Bagella Caterina Francesca , Frau Claudia , Ruiu Elisa , Othmani Sabrine , Gusinu Giansalvo , Masala Carla , Sechi Leonardo Antonio , Solla Paolo , Defazio Giovanni
Published: December 2023

Olfactory dysfunction is a prevalent non-motor symptom in Parkinson’s disease (PD), affecting approximately 65–90% of subjects. PD patients may also report odor perception in the absence of any external source, often referred to as olfactory hallucinations (OHs) or phantosmia. This study aims to explore the current understanding of OHs in PD and offer a comprehensive overview of their prevalence and characteristics. We conducted a systematic search of the literature published on PubMed from inception to July 2023 regarding OHs in PD, following PRISMA guidelines. From the 2875 studies identified through database searching, 29 studies fulfilled the necessary criteria and underwent data extraction. The frequency of OHs in PD patients varies widely, ranging from 0.5% to 18.2%, with female prevalence ranging from 36% to 75% of the patients. Olfactory experiences may vary widely, ranging from pleasant scents to unpleasant odors. Several studies have indicated the concurrent presence of other types of hallucinations alongside phantosmia, especially visual and auditory hallucinations. OHs in PD are a type of hallucination that has been largely overlooked. To gain a deeper understanding of OHs in PD patients, the next crucial step should involve the development and validation of a dedicated questionnaire.
Bidirectional Associations between Parental Feeding Practices and Child Eating Behaviors in a Chinese Sample
Authors: Wang Jian , Wu Ruxing , Wei Xiaoxue , Chang Yan-Shing , Tang Xianqing , Zhu Bingqian , Cao Yang , Wu Yinghui , Zhu Daqiao
Published: December 2023

Background: Child eating behaviors (CEBs) and parental feeding practices (PFPs) play critical roles in childhood obesity. However, the bidirectional relationships between CEBs and PFPs remain equivocal. This longitudinal study aimed to explore their bidirectional relationships. Methods: A convenience sample of 870 parents with preschoolers was recruited in this longitudinal study (Shanghai, China). Three non-responsive feeding practices (NFPs), three responsive feeding practices (RFPs), five CEBs, and covariates were collected using validated questionnaires at baseline and the 6-month follow-up. Cross-lagged analyses using structural equation modeling (SEM) were performed to examine their bidirectional relationships. Results: Eight hundred and fifty-three parents completed questionnaires, with a response rate of 98%. The mean age of their children at baseline was 4.39 years (standard deviation = 0.72 years). Eighteen out of sixty longitudinal cross-lagged paths were statistically significant. Parental encouragement of healthy eating and content-restricted feeding were found to be bidirectionally associated with child food fussiness. Four parent-driven associations and one child-driven association were identified between RFPs and CEBs. For example, monitoring was negatively associated with children’s unhealthy eating habits (β = −0.066, standard error (SE) = 0.025, p < 0.01). Eight child-driven associations and one parent-driven association were observed between NFPs and CEBs. For example, higher child satiety responsiveness predicted a higher pressure to eat (β = 0.057, SE = 0.029, p < 0.01) and the use of food as a reward (β = 0.083, SE = 0.031, p < 0.01). Conclusions: There were bidirectional, parent-driven, and child-driven associations. Parents should be encouraged to adopt RFPs to shape CEBs. Increasing parents’ understanding of CEBs and providing them with reasonable coping strategies would help optimize PFPs.
The Causal Relationship between the Morning Chronotype and the Gut Microbiota: A Bidirectional Two-Sample Mendelian Randomization Study
Authors: Chen Manman , Wang Zhenghe , Tan Din Son , Wang Xijie , Ye Zichen , Xie Zhilan , Zhang Daqian , Wu Dandan , Zhao Yuankai , Qu Yimin , Jiang Yu
Published: December 2023

Background: Numerous observational studies have documented an association between the circadian rhythm and the composition of the gut microbiota. However, the bidirectional causal effect of the morning chronotype on the gut microbiota is unknown. Methods: A two-sample Mendelian randomization study was performed, using the summary statistics of the morning chronotype from the European Consortium and those of the gut microbiota from the largest available genome-wide association study meta-analysis, conducted by the MiBioGen consortium. The inverse variance-weighted (IVW), weighted mode, weighted median, MR-Egger regression, and simple mode methods were used to examine the causal association between the morning chronotype and the gut microbiota. A reverse Mendelian randomization analysis was conducted on the gut microbiota, which was identified as causally linked to the morning chronotype in the initial Mendelian randomization analysis. Cochran’s Q statistics were employed to assess the heterogeneity of the instrumental variables. Results: Inverse variance-weighted estimates suggested that the morning chronotype had a protective effect on Family Bacteroidaceae (β = −0.072; 95% CI: −0.143, −0.001; p = 0.047), Genus Parabacteroides (β = −0.112; 95% CI: −0.184, −0.039; p = 0.002), and Genus Bacteroides (β = −0.072; 95% CI: −0.143, −0.001; p = 0.047). In addition, the gut microbiota (Family Bacteroidaceae (OR = 0.925; 95% CI: 0.857, 0.999; p = 0.047), Genus Parabacteroides (OR = 0.915; 95% CI: 0.858, 0.975; p = 0.007), and Genus Bacteroides (OR = 0.925; 95% CI: 0.857, 0.999; p = 0.047)) demonstrated positive effects on the morning chronotype. No significant heterogeneity in the instrumental variables, or in horizontal pleiotropy, was found. Conclusion: This two-sample Mendelian randomization study found that Family Bacteroidaceae, Genus Parabacteroides, and Genus Bacteroides were causally associated with the morning chronotype. Further randomized controlled trials are needed to clarify the effects of the gut microbiota on the morning chronotype, as well as their specific protective mechanisms.
Compaction Properties of Particulate Proteins in Binary Powder Mixtures with Common Excipients
Authors: Holmfred Else , Hirschberg Cosima , Rantanen Jukka
Published: December 2023

The increasing interest in protein- and peptide-based oral pharmaceuticals has culminated in the first protein-based products for oral delivery becoming commercially available. This study investigates the compaction properties of proteins in binary mixtures with common excipients up to 30% (w/w) of particulate protein. Two model proteins, lysozyme and bovine serum albumin, were compacted with either microcrystalline cellulose, spray-dried lactose monohydrate, or calcium hydrogen phosphate dihydrate at two different compaction pressures. Compared to the compacted pure materials, a significant increase in the tensile strength of the compacts was observed for the binary blends containing lysozyme together with the brittle excipients. This could be attributed to the increased bonding forces between the particles in the blend compared to the pure materials. The use of bovine serum albumin with a larger particle size resulted in a decrease in tensile strength for all the compacts. The change in the tensile strength with an increasing protein content was non-linear for both proteins. This work highlights the importance of considering the particulate properties of protein powders and that protein-based compacts can be designed with similar principles as small-molecules in terms of their mechanical tablet properties.
Prompt Analysis and Design for Passively Mode-Locked Solid-State Lasers with Semiconductor Saturable Absorbers
Authors: Cheng Pin-Wen , Hsu Yu-Hsin , Liang Hsing-Chih , Huang Kai-Feng , Chen Yung-Fu
Published: December 2023

The critical pump power for achieving passively continuous-wave mode-locking in a solid-state laser is analytically derived from the spatially dependent rate equations and the criterion for the intracavity pulse energy. A prompt way is proposed to straightforwardly design the cavity for passively mode-locked solid-state lasers. Complete experiments are performed to demonstrate the proposed cavity design and, simultaneously, to verify the theoretical model for the critical pump powers. It is interestingly observed that even though a larger modulation depth causes a higher critical pump power, it can generate a shorter pulse width in return.
Traditional Knowledge Evolution over Half of a Century: Local Herbal Resources and Their Changes in the Upper Susa Valley of Northwest Italy
Authors: Sulaiman Naji , Zocchi Dauro M. , Borrello Maria Teresa , Mattalia Giulia , Antoniazzi Luca , Berlinghof S. Elisabeth , Bewick Amber , Häfliger Ivo , Schembs Mia , Torri Luisa , Pieroni Andrea
Published: December 2023

Susa Valley, located in the Italian Western Alps, has served as a meeting point for cultural, spiritual, and commercial exchange for a long period of history. The valley’s role as one of the main connecting routes between south and southwestern Europe resulted in its acquisition of a rich traditional ecological knowledge. However, like other Italian mountainous valleys, this valley has suffered from abandonment and depopulation in the past 50 years. Our study aims to investigate the current ethnobotanical medicinal knowledge in the valley and to compare our findings with a study conducted over 50 years ago in the same area. In 2018, we conducted 30 in-depth semi-structured interviews on medicinal plants and food-medicines used in the Susa Valley. We documented 36 species, of which 21 species were used for medical purposes and 15 species were used as food-medicine. The comparison with the previous study on medicinal herbs conducted in 1970 in the valley demonstrated a significant decrease in both the knowledge and use of medicinal plants, which could be attributed to socioeconomic, cultural, and possibly environmental changes that occurred in the past half-century. Our study highlights several promising species for future use as nutraceuticals, food, and medicinal products, such as Taraxacum officinale, Urtica dioica, and Artemisia genipi.
Karyotypes and Physical Mapping of Ribosomal DNA with Oligo-Probes in Eranthis sect. Eranthis (Ranunculaceae)
Authors: Mitrenina Elizaveta Yu. , Alekseeva Svetlana S. , Badaeva Ekaterina D. , Peruzzi Lorenzo , Artemov Gleb N. , Krivenko Denis A. , Pinzani Lorenzo , Aytaç Zeki , Çeçen Ömer , Baasanmunkh Shukherdorj , Choi Hyeok Jae , Mesterházy Attila , Tashev Alexander N. , Bancheva Svetlana , Lian Lian , Xiang Kunli , Wang Wei , Erst Andrey S.
Published: December 2023

A comparative karyotype analysis of four species of yellow-flowered Eranthis sect. Eranthis, i.e., E. bulgarica, E. cilicica, E. hyemalis, and E. longistipitata from different areas, has been carried out for the first time. All the studied specimens had somatic chromosome number 2n = 16 with basic chromosome number x = 8. Karyotypes of the investigated plants included five pairs of metacentric chromosomes and three pairs of submetacentric/subtelocentric chromosomes. The chromosome sets of the investigated species differ mainly in the ratio of submetacentric/subtelocentric chromosomes, their relative lengths, and arm ratios. A new oligonucleotide probe was developed and tested to detect 45S rDNA clusters. Using this probe and an oligonucleotide probe to 5S rDNA, 45S and 5S rDNA clusters were localized for the first time on chromosomes of E. cilicica, E. hyemalis, and E. longistipitata. Major 45S rDNA clusters were identified on satellite chromosomes in all the species; in E. cilicica, minor clusters were also identified in the terminal regions of one metacentric chromosome pair. The number and distribution of 5S rDNA clusters is more specific. In E. cilicica, two major clusters were identified in the pericentromeric region of a pair of metacentric chromosomes. Two major clusters in the pericentromeric region of a pair of submetacentric chromosomes and two major clusters in the interstitial region of a pair of metacentric chromosomes were observed in E. longistipitata. E. hyemalis has many clusters of different sizes, localized mainly in the pericentromeric regions. Summarizing new data on the karyotype structure of E. sect. Eranthis and previously obtained data on E. sect. Shibateranthis allowed conclusions to be formed about the clear interspecific karyological differences of the genus Eranthis.
A Review on Barrier Properties of Cellulose/Clay Nanocomposite Polymers for Packaging Applications
Authors: Jali Sandile , Mohan Turup Pandurangan , Mwangi Festus Maina , Kanny Krishnan
Published: December 2023

Packaging materials are used to protect consumer goods, such as food, drinks, cosmetics, healthcare items, and more, from harmful gases and physical and chemical damage during storage, distribution, and handling. Synthetic plastics are commonly used because they exhibit sufficient characteristics for packaging requirements, but their end lives result in environmental pollution, the depletion of landfill space, rising sea pollution, and more. These exist because of their poor biodegradability, limited recyclability, etc. There has been an increasing demand for replacing these polymers with bio-based biodegradable materials for a sustainable environment. Cellulosic nanomaterials have been proposed as a potential substitute in the preparation of packaging films. Nevertheless, their application is limited due to their poor properties, such as their barrier, thermal, and mechanical properties, to name a few. The barrier properties of materials play a pivotal role in extending and determining the shelf lives of packaged foods. Nanofillers have been used to enhance the barrier properties. This article reviews the literature on the barrier properties of cellulose/clay nanocomposite polymers. Cellulose extraction stages such as pretreatment, bleaching, and nanoparticle isolation are outlined, followed by cellulose modification methods. Finally, a brief discussion on nanofillers is provided, followed by an extensive literature review on the barrier properties of cellulose/clay nanocomposite polymers. Although similar reviews have been presented, the use of modification processes applied to cellulose, clay, and final nanocomposites to enhance the barrier properties has not been reviewed. Therefore, this article focuses on this scope.
Evaluation of Supercapacitive Properties of a PPY/PANI Bilayer Electrodeposited onto Carbon-Graphite Electrodes Obtained from Spent Batteries
Authors: Oliveira Rafaela D. , Santos Cleverson S. , Hryniewicz Bruna M. , Marchesi Luís F. , Pessoa Christiana A.
Published: December 2023

Recently, many efforts have been made to reuse spent batteries in response to the growing demand for sustainable materials production. In parallel, supercapacitors have attracted significant attention for their use in addressing some of the limitations of conventional capacitors and batteries. In this context, this paper describes the preparation, characterization, and supercapacitive performance evaluation of carbon-graphite (CG) electrodes obtained from spent zinc–carbon batteries and modified with polypyrrole (PPY) and polyaniline (PANI). The parameters of PPY and PANI electropolymerization were optimized. CG/PPY, CG/PANI, and CG/PPY/PANI electrodes were obtained to compare their electrochemical responses. Cyclic voltammetry (CV), galvanostatic charge–discharge curves (GCDC), and electrochemical impedance spectroscopy (EIS) were used to evaluate the pseudocapacitive properties of the CG/PPY/PANI-modified electrode. The CG/PPY/PANI electrode showed a specific capacitance of 3416 mF cm−2 in a current density of 2 mA cm−2 and a retention capacity of 76% after 850 GCDC cycles. Thus, CG/PPY/PANI electrodes are shown to be good candidates for use in the development of energy storage devices. In addition, reused CG electrodes from spent batteries have other advantages like low cost, facile construction, and environmental friendliness.
Analysis of Essential Oil of Salix babylonica Collected in Vietnam: Phytochemical Components and Antibacterial and Anticancer Activity
Authors: Hoang Phu Hiep , Tran Thien Hien , Pham Van Khang
Published: December 2023

This study investigated the chemical compositions and inhibitory activities of essential oils (EOs) of Salix babylonica from Vietnam. The gas chromatography–mass spectrometry (GC/MS) system was used to analyze the chemical compositions of Salix babylonica essential oils. A total of twenty-eight and thirty-one compounds were identified in essential oils of the leaves and bark, among which many chemical compositions were identified for the first time in this plant. Salix babylonica essential oils demonstrated antibacterial activities against Gram-negative strains such as Pseudomonas aeruginosa (PA) and Escherichia coli and Gram-positive strains such as Staphylococcus aureus (SA), and demonstrated anti-cancer activities against three cancer cell lines (HepG2, MCF-7 cell, and A549). The evaluation of the ability to inhibit three strains of microorganisms and inhibit the growth of three cancer cell lines was first conducted using essential oils extracted from the plant species S. babylonica collected in Asia, which will be the basis for using essential oils of this plant in medicine.
Multi-Objective Optimization of Injection Molding Process Parameters for Moderately Thick Plane Lens Based on PSO-BPNN, OMOPSO, and TOPSIS
Authors: Liu Feng , Pang Jianjun , Xu Zhiwei
Published: December 2023

Injection molding (IM) is an ideal technique for the low-cost mass production of moderately thick plane lenses (MTPLs). However, the optical performance of injection molded MTPL is seriously degraded by the warpage and sink marks induced during the molding process with complex historical thermal field changes. Thus, it is essential that the processing parameters utilized in the molding process are properly assigned. And the challenges are further compounded when considering the MTPL molding energy consumption. This paper presents a set of procedures for the optimization of injection molding process parameters, with warpage, sink marks reflecting the optical performance, and clamping force reflecting the molding energy consumption as the optimization objectives. First, the orthogonal experiment was carried out with the Taguchi method, and the S/N response shows that these three objectives cannot reach the optimal values simultaneously. Second, considering the experimental data scale, the back propagation neural network updated by the particle swarm optimization method (PSO-BPNN) was applied to establish the complex nonlinear mapping relationship between the process parameters and these three trade-off objectives respectively. Then, the Pareto optimal frontier of the multi-objective optimization problem was attained by multi-objective particle swarm optimization using a mutation operator and dominance coefficient algorithm (OMOPSO). And the competitive relationship between these objectives was further confirmed by the corresponding pairwise Pareto frontiers. Additionally, the TOPSIS method with equal weights was employed to achieve the best optimal solution from the Pareto optimal frontier. The simulation results yielded that the maximum values of warpage, sink marks, and clamping force could be reduced by 7.44%, 40.56%, and 5.56%, respectively, after optimization. Finally, MTPL products were successfully fabricated.
The Impact of Farm and Industrial Feed Waste on the Safety Parameters of Tenebrio molitor Larvae
Authors: Jankauskienė Agnė , Aleknavičius Dominykas , Antanaitis Šarūnas , Kiseliovienė Sandra , Wedi Philipp , Šumskienė Marijona , Juknienė Ignė , Gaižauskaitė Žydrūnė , Kabašinskienė Aistė
Published: December 2023

The rising global demand for animal-based food has an increasingly detrimental ecological impact, exacerbated by significant food waste (approximately one-third of all food). This research aimed to analyze the possibility of changing the usually balanced feed with sustainable alternatives that remain as a by-product of the production of farms, grain processing, and breweries, thus promoting the sustainability of agriculture. The mealworm larvae were reared on different substrates: (1) agar-agar gels, wheat bran, and brewer’s yeast, (2) carrots, wheat bran, and brewer’s yeast, (3) sprouted potatoes, wheat bran, and brewer’s yeast, and (4) carrots, brewers’ spent grain and brewer’s yeast. For analysis, the frozen larvae were lyophilized and tested for chemical safety in three accredited laboratories. The results have shown that all tested samples had lower levels of pesticides than the detection limit. In scientific literature, we didn’t find studies on polycyclic aromatic hydrocarbons (PAH). In our study, we found PAH in the substrate and these toxins, as our study shows, can also enter the larvae, but no significant accumulation was observed (sum of benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene and chrysene was 0.0007 mg/kg). Furthermore, the total content of PAH, benzo(a)pyrene and histamine did not exceed recommended levels. We have noticed that the highest concentration of heavy metals (e.g., chromium—1.45 ± 0.02) was found in the sample with the brewer’s by-products. While numerous studies utilize plant-derived by-products, the accumulation of glycoalkaloids has not been explored. Among the all glycoalkaloids (tomatidin, tomatine, α-solanine, α-chaconine and solanidin), amounts of α-solanine and α-chaconine were the highest, detected in the sample with sprouted potatoes (175.12 ± 0.21 and 139.32 ± 0.32 mg/kg, respectively). The amount of total putrescine, tyramine, spermine, and spermidine in mealworm larvae was statistically higher compared to the amount detected in the substrate, and histamine level-on the contrary, was statistically significantly lower compared to the amount detected in the substrate. Considering the amount of toxic substances found in the substrate from the by-products, we can assume that mealworms did not accumulate high levels of toxins, which would violate regulations.