bluuebunny/crossref_metadata_2025 huggingface dataset:
A validated stability indicating LC-MS compatible RP-HPLC assay and dissolution methods for marketed formulation Stribild
Authors: Harini U , Pawar AKM
Published: January 2019

Objective: The prime objective of the current work is to develop a simple, rapid, efficient, economical and stability indicating LC-MS (liquid chromatography–mass spectroscopy) compatible RP - HPLC (reverse phase – high performance liquid chromatography) method for the analysis of emtricitabine (EMT), tenofovir disoproxil fumarate (TDF), cobicistat (COB) and elvitegravir (ELV) in bulk, marketed formulation (Stribild) and in In-vitro dissolution method.

Method: The chromatography was achieved on Unisol C18 column (250 × 4.0 mm, 3 µ) with a mobile phase combination of acetate buffer (adjusted with dilute glacial acetic acid to pH 4) and acetonitrile in gradient mode at a flow rate of 1mL/min and the detection was performed at 260 nm using PDA (photo diode array) detector. Forced degradation studies were performed and the % degradation under various stress conditions was calculated. The developed RP-HPLC method was applied for Stribild tablets to study the dissolution profile.

Results: The retention times for emtricitabine, tenofovir disoproxil fumarate, cobicistat and elvitegravir were 5.7, 12.1, 16.3 and 19.4 min respectively. The % degradation was below 20% which is within the limits. The percent drug release was found to meet USP specification, i.e. not less than 80% of amount of labeled drug EMT, TDF, COB and ELV dissolved in 30min.

Conclusion: The method was validated as per ICH guidelines and all the validation parameters were within the compendial requirements. The proposed method can be successfully adopted for the analysis of Stribild tablets in pharmaceutical industries.

Keywords: Stribild, emtricitabine, tenofovir disoproxil fumarate, cobicistat, elvitegravir
Successful treatment of ureteric calculi with constitutional homoeopathic medicine Lycopodium clavatum: A Case report
Authors: Hati Akshaya Kumar , Rath Sasmita , Nayak Chintamani , Raj Induprava , Sahoo Amulya Ratna , PAITAL BISWARANJAN
Published: January 2019

Introduction

Formation of stone in the urinary tract, kidney, ureter and bladder is called as Urolithiasis. Formation of urinary stones is very common. About 5-15% population are affected with urinary stone, and, therefore, causes high morbidity in comparison to the above types of stone formation. Shock wave lithotripsy and ureteroscopy along with conservative treatments are the most common approaches for the treatment of calculi, although considered as expressive in one hand, and on the other hand, such interventions may lead to complications. Therefore, alternative medicines give a second thought for the treatment of urolithiasis because it avoids surgical interventions. Here we present a case study for the successful treatment of urolithiasis by a homoeopathic medicine Lycopodium clavatum in a 43 years old male.

Case Profile

A 43-year-old male patient with intense pain in the right loin for 5-6 days, increased frequency of urination, ineffectual urination, severe pain during urination, and finally with the pain score was 9, was considered for treatment in the present study. Based on his complete case history, Lycopodium clavatum at potencies of 0/1 to 0/6 was prescribed to him.

Conclusion

Correct homoeopathic organ specific or constitutional formulation(s) selected based on specific important symptoms can also be efficacious in diseases such as ureteric stone. Constitutional medicine Lycopodium clavatum is usually prescribed when the patient is with right side pain with ureteric stone and it is justified in the present case report. Randomized control trial is suggested to ascertain the results obtained in the present study i.e. successful treatment of urolithiasis with the constitutional homeopathic formulation Lycopodium clavatum.
An updated review on Anti-Alzheimer’s herbal drugs
Authors: Sanka Nihitha , Santhipriya N , Nadendla Rama Rao
Published: January 2019

Alzheimer’s disease (AD) is related to cognitive impairment, dementia observed generally in aged population due to neurodegeneration in an ongoing manner. It gradually worsens memory power of the patient. The hallmark diagnosis features includes formation of senile plaques and Neurofibrillary tangles (NFT’S) [1, 2]. Too little availability of Acetyl choline (ACh) a neurotransmitter in the cerebral region due to metabolism by an enzyme Acetyl choline esterase before showing its action and neural death are the primary reasons for AD. There are many categories of Anti-Alzheimer’s drugs available for management of AD in the market but due to lack of patient compliance successful outcomes were not observed [3]. Apart from this including Nutraceuticals in diet daily routine, Aromatherapy, modifications in the regular schedule, practicing yoga regularly relaxes mind and body from tensions, insomnia, blood circulation, detoxification of organs due to rhythmic breathings and reduce frequency of incidence of headache  are proven to show best results by relieving stress according to survey[4-9]. At present herbal medicine has turn out to be best choice for the management of AD because of its availability, very economic, good patient compliance, ease of formulation and lower deleterious side effects [10, 11]. Novel techniques can be used for the development of herbal medicine. This review totally discuses about the occurrence of AD, its Pathophysiology, different stages in the disorder, various selective therapeutic targets for AD, available Anti-AD herbal drugs such as Curcumin, Withania somnifera, Bhrami, Ginkgo biloba, guggul, ginseng, herbs with essential oils, volatile oils, source and cultivation of the herbs, mechanism of action of the Phytochemicals in the herb responsible for treating AD.

Keywords: Alzheimer’s disease (AD), cognitive impairment, Dementia, Senile plaques, Nutraceuticals, Herbal medicine, Phytoconstituents.
Formulation and evaluation of orodispersible tablets of lornoxicam
Authors: Ansari K Kareemuddin , Sharma Neeraj
Published: January 2019

Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. The purpose of this investigation was to develop mouth dissolving tablets of Lornoxicam using KYRON T-314 (Polacrillin Potassium) as a novel superdisintegrant. Mouth dissolving tablets of lornoxicam were prepared by wet granulation technique using KYRON T-314 as superdisintegrant and menthol as subliming agent. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Keywords: KYRON T-314, Mouth dissolving tablet, Lornoxicam, Subliming agent, Superdisintegrant
VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW
Authors: Zhu George , Ahmed Al-kaf Ali Gamal
Published: January 2019

Vitamin A and its derivative retinoic acid (13-cis RA, 9-cis RA, all-trans RA) and recent tamibarotene have been shown a broad variety of biological actives in human, such as vision, embryonic development, cell growth and cellular differentiation and immune function. These precise functions of RA are mediated by their retinoic acid receptors (RARs). In the past five decades, retinoic acid (RA) proved therapeutic benefits in cancer prevention, in skin diseases and in acute promyelocytic leukemia (APL).The elucidation of the molecular basis of vitamin A acid and its retinoid pharmacology in APL has been illustrated in several publications, the detail molecular model of gene regulation had also been proposed by Zhu in earlier 90s. A molecular model is further revised. As an approach to APL treatment, one possible the action of retinoic acid (RA), A consensus sequence (TCAGGTCA motif ) has been postulated for thyroid hormone (TRE) and retinoic acid responsive element (RARE)-containing in the promoter region of target genes. High dose of RA-RARE-PML/RARa complexes in intracellular localization appears to relieve repressors from DNA-bound receptor, including the dissociation of co-re pressor complexes N-CoR, SMRT and HDACs from PML-RARa or PML-RARa/RXR. Also release PML/RARa -mediated transcription repression. This transcriptional derepression occurs at RARa target gene promoter. Consequentially, PML-RARa chimera converted receptor from a repressor to a RA-dependent activator of transcription. The resulting pml-RARA oncoprotein proteolytic degradation occurs through the autophagy-lysosome pathway and the ubiquitin SUMO-proteasome system(UPS) as well as caspase 3, or lysosomal protease (cathepsin D) enzyme or/and EI-like ubiquitin-activating enzyme(UBEIL) induction. Accordingly the expression level of PML-RARa downregulated. PML protein relocalizes into the wild-type nuclear body (PML-NB) configuration or a truncated PML-RARa fusion fragment detected or/and the wild-type RAR upregulated. An effect is to relieve the blockade of pml/RARa-mediated RA dependent promyelocytic differentiation, and retinoic acid (9-cid RA,ATRA, Am80) in APL therapy. Here, oncogenic pml/RARa as constitutive transcriptional repressor that block myeloid differentiation at promyelocytic phenotype. RA can overcome the transcrptional repressor activity of pml/RARa. The oncogenic pml/RARa uncovers a pathogenic role in leukemogenesis of APL through blocking promyelocytic differentiation. This oncogenic receptor derivative pml/ RARa chimera is locked in their "off" regular mode thereby constitutively repressing transcription of target genes or key enzymes (such as AP-1, PTEN, DAPK2,UP.1, p21WAF/CCKN1A）that are critical for differentiation of hematopoietic cells. This is first described in eukaryotes.
FORMULATION AND EVALUATION OF METOCLOPRAMIDE HCL RECTAL SUPPOSITORIES
Authors: Chioma Deborah Ejiogu , Yusuf Felix Sunday
Published: January 2019

Metoclopramide hydrochloride is a dopamine receptor antagonist, used mostly for stomach and esophageal problems as it is a prokinetic agent. The aim of the present study was to design and evaluate the suppositories of Metoclopramide HCl.  Six different, rectal suppositories were developed by fusion (pour-moulding) method by employing various hydrophilic and hydrophobic polymeric bases like gelatin, PEG-400 and hydrogenated vegetable oil using propylene glycol as plasticizer and beeswax as hardening agent.  Metoclopramide HCl suppositories were evaluated for appearance, weight variation, drug content uniformity, liquefaction time and temperature, micro-melting range, disintegration and in-vitro release study.  The in-vitro release rate data was evaluated statistically and was found that from all the formulations the drug release is by diffusion mechanism. Optimum formulation of batch S1 has shown 83.427% Metoclopramide HCl in a study of 2 hrs. These drug release results are supported by the disintegration time of suppositories. Lesser the disintegration time faster the drug release. All formulations has shown zero, first and Higuchi release kinetics. The result suggests that the Metoclopramide HCl suppositories can be prepared by employing hydrophilic and hydrophobic polymers.
A COMPREHENSIVE REVIEW ON SUSTAINED RELEASE MATRIX TABLETS: A PROMISING DOSAGE FORM
Authors: Prakhar Agarwal , Semimul Akhtar
Published: January 2019

Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, least aseptic and flexibility in the design of dosage form. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance delivery. Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers. Matrix controls the free rate of drug. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.
MODULAR REHABILITATION SYSTEM AT THE STATIONARY PHASE OF REHABILITATION OF MILITARY MEN AFTER ACUTE NONREVMATIC MYOCARDITIS
Authors: Bondar S. A. , Zakrevskiy Yu. N. , Balahnov D. O. , Butikov V. P. , Pivkin V. M.
Published: January 2019

The paper presents the experience of rehabilitation treatment for servicemen who had suffered from acute nonrheumatic myocarditis. The treatment was conducted in the 1469 Naval Clinical Hospital of the Northern Fleet with using an 8-modular system of medical rehabilitation activities: a laboratory-diagnostic cluster with a patient’s rehabilitation and expert evaluation and a rehabilitation prognosis; drug therapy, diet therapy, psychosomatic diagnosis and correction of the emotional state; therapeutic exercise with restoration of physical performance and adaptive health parameters; information cluster — providing the patient with a complete and accessible understanding of information about a healthy lifestyle; physiotherapeutic non-pharmacological correction of physiological disorders, activation of endogenous protective systems of the body; functional diagnostics complex: a study of restoration of functioning parameters for cardiovascular and respiratory systems, the development of the body’s adaptation to physical exertion. As a result of using the modular system, a decrease in the average bed-day during the rehabilitation phase for patient after mild acute myocarditis was 16,6% (from 17,5±1,3 to 14,6±2,7 days); after moderate myocarditis — 8.1% (from 22,3±2 to 20.5±1,8 days); and after severe — 5,9% (from 27,2±3,5 to 25,6±1,2 days). The rehabilitation program, which has been developed basing on principles of the theory of modules, is a dynamic, easily simulated system with a combination of variable and permanent elements, that allows to reduce the cost of treatment and rehabilitation in mild myocarditis by 10,6±0,9%, in moderate myocarditis — by 7,2±0,8%, and in severe myocarditis — by 3,7±0,4%.
SYSTEM OF MEDICAL SUPPORT OF NAVAL AVIATION OF THE NAVY: PROBLEM ISSUES AND WAYS OF THEIR SOLUTION
Authors: Mosyagin I. G. , Boyko I. M. , Pulyaev M. N.
Published: January 2019

The article discusses the problematic issues of medical support of naval aviation: in the organizational and staff structure of the medical service, in the field of material support of the medical service units, medical and psychological rehabilitation of the flight personnel, in the field of social protection of aviation medicine specialists of the Navy. The authors suggested ways to solve these problems. Necessity of centralization and effective quantitative and qualitative optimization of the medical personnel who provide medical support for naval aviation is noted. Attention is paid to the developing of a system for training medical personnel providing flights, as well as the creation of conditions that guarantee high-quality medical and psychological rehabilitation of flight personnel. Introduction of modern technologies and equipment into practice of aviation medicine of the Navy, construction and implementation of total renovation and external repairs of buildings of medical units is considered to be an important independent direction in the development of the medical support system for naval aviation. The authors emphasize the expediency of the improving the regulatory framework aimed at ensuring the social protection of aviation medical personnel of the Navy. Development of the medical support system for naval aviation for the period up to 2025 is proposed to be implemented by the stages: the first stage (2018-2020), the second stage (2019-2025). General and particular indicators of effectiveness of package of measures aimed to improve the system of medical support of naval aviation are formulated.
Testicular Awareness: The What, the Why, and the How
Authors: Saab Mohamad M , Hegarty Josephine , Landers Margaret
Published: January 2019

Globally, men have a lower life expectancy than women and health outcomes among men are poorer than women. Only Australia, Brazil, Iran, and Ireland possess national men’s health policies. Testicular disorders can have a negative effect on men’s health and are rarely addressed in these policies. Findings from the empirical literature on men’s awareness of testicular disorders suggest that men’s knowledge of testicular disorders is lacking and their intentions to seek timely medical attention for testicular symptoms are low. This paper aims to introduce the concept of ’testicular awareness’ and explore its implications for health research, practice, and education. The key attributes of ‘testicular awareness’ include: (i) familiarity with own testes; (ii) knowing what is normal versus abnormal; (iii) ability to detect an abnormality; and (iv) knowing own risk factors. Testicular awareness is an all-encompassing concept since it helps men become familiar with an intimate body part that is seldom discussed and enables them to detect testicular abnormalities and to seek timely medical attention for testicular symptoms, regardless of the ultimate diagnosis. Testicular awareness can be promoted using a number of strategies, such as: (i) involving men in drafting men’s health policies that address testicular awareness; (ii) partnering with men to develop and test interventions promoting testicular awareness; (iii) being cognizant of the learning needs of men who are at risk of health disparities including those with low literacy and health literacy; (iv) promoting testicular awareness in clinical practice and health education; and (v) using men’s daily spheres of information to promote testicular awareness; these include but are not limited to: workplaces, universities, gyms, and community organizations.
DIÁLOGO COM O SAGRADO: Narrativas das benzedeiras e rezadeiras de Santo Amaro
Authors: Ribeiro Elder Pereira , De Sena Márcio Luis Moreira , Oreste Liverson Ferreira Santos
Published: January 2019

Este relato de experiência apresenta resultados da pesquisa sobre a Saúde em Santo Amaro: a partir dos saberes tradicionais das rezadeiras/benzedeiras que teve por objetivo analisar as práticas medicinais e espirituais com o sagrado. A pesquisa etnográfica foi realizada com as rezadeiras, dessa forma, estabelecendo fronteiras com os rituais de cura, fé e devoção, nos processos de aprendizagem, aos mais variados tipos de doenças, as rezas e as curas, sendo assim, realizadas por elas. As rezadeiras/benzedeiras são mulheres cujo valor histórico, tornando-se as suas benzeduras símbolo de resistência humana, na sua prática sobre as benzeduras. Entretanto, vale fomentar na pesquisa, sobretudo, as suas práticas também estão relacionadas a conhecimentos católicos, indígena, africana, com seus “cânticos” e “rezas” religiosas, trazendo consigo o desejo da fé de resultar o seu trabalho por alcances estabelecidos nas suas práticas reverenciadas assim as pessoas que procuram por elas.  O objeto é tentar caminhar ao longo da história, em conjunto com as práticas religiosas, percebendo as inúmeras implicações produzidas pela sociedade. O contexto etnográfico da pesquisa foi na cidade de Santo Amaro.

Palavras-chave: Saúde, Benzedeira, Espiritualidade.
A QUESTÃO DO AUTOCONHECIMENTO NA FILOSOFIA DE ORUNMILÁ
Authors: Noguera Renato
Published: January 2019

Partindo da ideia de Orfmilá, a filosofia é autoconhecimento, o propósito é a impressão de dois sentidos: ciência da cabeça e cartografia dos caminhos. O que podemos fazer é uma incursão em arranjos matemáticos sobre o Odu, analisando os elementos que constituem a cabeça e como encruzilhados dos caminhos. A base teórica está situada nos escritos de filósofas (os) nigerianas (os), principalmente Sophie Oluwole.

Palavras-chave: Orunmilá; filosofia; autoconhecimento; ori; caminhos.
A SEXUALIDADE NO CURRÍCULO AFRO-BRASILEIRO
Authors: Soares Emanoel Luís Roque , Vasconcelos José Gerardo
Published: January 2019

A intenção deste texto é mostrar que por muito tempo, o negro vindo da África escravizado e os afrodescendentes nascidos no Brasil e no mundo foram adestrados para uma normatização que tentou a todo custo condicioná-los à cultura do colonizador (concilio de Trento 1546 a 1563), sem levar em consideração a sua própria cultura, postas a força, através do chicote e da repressão escravistas, amplamente apoiada com o auxílio moralista da igreja e, mais tarde, quando tem acesso a escola formal esta cultura vai ser imposta através de uma espécie de catequismo didático curricular que, sem dúvida, vai ser um dos vários desserviços a nossa tolerância, respeito e aceitação da diferença e que vem a gerar, até os dias atuais atos de características machista, sexista e preconceituosa, promovendo até doenças Foucault (2006). Desta maneira, nossa problemática é como adequar o currículo para nos livrarmos ou diminuirmos estas mazelas. Pra tal empreitada trilharemos o seguinte caminho: Primeiro explicar o paradigma da cientificidade e como ele não dá conta das ciências humanas Kuhn (2016), Figueiredo (1995) e nem dos currículos na pós-modernidade Doll Jr.(1997) Macedo (2000). Mostrar porque o corpo afrodescendente deve ser educado, a partir de um currículo onde apareça a sua cultura Macedo (2000), Geertz (2013), Laraia (2004) e a cultura do outro com o qual se convive uma vez, que a cultura é semiótica e apresenta-se e significa-se de diversas facetas e, ainda, aquele que a estuda (o etnólogo) a interpreta e descreve alisando as diversas intenções simbólicas contidas na mesma. Procurar propor um currículo que tenha como base a cultura afrodescendente apoiada na mitologia ancestral dos orixás Prandi (2001), Verger (1997) e em textos de letras de músicas da MPB que versam sobre sexualidade.

PALAVRAS-CHAVE: sexualidade, currículo, cultura, afrodescendente.
ENTREVISTA SOBRE PEDAGOGIA QUEER E EDUCAÇÃO INCLUSIVA
Authors: González Aldo Ocampo
Published: January 2019

A compreensão epistemológica da Educação Inclusiva expressa um funcionamento diaspórico, isto é, as formas de construção do seu conhecimento, operam através de uma dispersão do conhecimento, distribuída por uma multiplicidade de geografias epistêmicas, entre elas, Feminismo, Teoria Queer, Estudos Postcolonial, entre outros. Neste caso, as contribuições do Feminismo e dos Estudos Queer, tornam-se instâncias chave do conhecimento para promover a proposta de uma nova racionalidade - cada vez mais ampla em suas propostas e sistemas de raciocínio - para justificar a relevância da inclusão para além da produção de ficções baseadas na inclusão no mesmo - dentro da Ciência da Educação no século XXI. Retornando à idéia de Educação Inclusiva como "categoria de análise" e "dispositivo macroeducativo" (Ocampo, 2017), esta entrevista analisa as interseções políticas, epistêmicas e pedagógicas que a Pedagogia Queer compartilha com a Educação Inclusiva; reconhecendo o primeiro como uma das suas principais memórias epistêmicas de transformação. Nessa ocasião, o Dr. Nilson Dinis, acadêmico do Departamento de Educação e Não-Programa de Graduação em Educação da Universidade Federal de São Carlos, nos dá reflexões interessantes sobre a configuração de um campo que, embora exprima uma longa história em epistemologias subalternas, é conhecida e entendida a partir de uma posição de afastamento e periferia na educação e no treinamento de professores. O Dr. Dinis também aprofunda a compreensão do trans, sua agência e repercussões políticas nas gramáticas educacionais. Ao mesmo tempo, dá idéias-chave para abordar o currículo, as lógicas operacionais das instituições educacionais e a co-gestão das identidades sexuais no contexto educacional. Indubitavelmente, suas contribuições contribuem para posicionar um tópico que as políticas públicas e educacionais no campo da produção de Educação Inclusiva, é subalternizado, gerando novas estratégias de apartheid do conhecimento ou em termos de Spivak (1998) ou Foucault (1970) , a violência epistêmica, se tornam os chamados "vazios da diversidade", que são apenas declarações que atraem a noção de diferença para o centro do capitalismo, sem abordá-lo, deixando-o em uma situação permanente de desvalorização social e indefesa. Em suma, a entrevista espelha uma crescente complexidade, convidando-nos a superar as simplicidades pedagógicas a este respeito. 

Palavras-chave: pedagogia queer, educação inclusiva, multiplicidade de diferenças, ação e resistência política.
Microstructure evolution and dielectric properties of Ce-doped SrBi4Ti4O15 ceramics synthesized via glycine-nitrate process
Authors: Du Huiling , Ma Cuiying , Ma Wuxiang , Wang Haiting
Published: January 2019

Ce-doped strontium bismuth titanate (SrBi4Ti4O15, SBT) powders were prepared
by glycine-nitrate process at 400-500?C and the ceramics were sintered at
980?C. The phase composition, morphology and electric properties were
investigated. It was found that the calcined powders consist of a single
phase SBT and the calcination temperature is lower than that for the
conventional solid state method. The morphology of Cedoped SBT is flake-like
and the layer size decreases with Ce-addition from 12 to 2?m confirming
that the addition of Ce3+ inhibits grain growth. The Curie temperature of
Ce-doped SBT increased for about 20?C compared to the pure SBT. The tan ?
was ~0.005 at 35?C and even below 0.05 up to 400?C. The temperature
coefficient of dielectric constant was ~0.012 and the rate of frequency
change was 0.01-0.04, which indicated the high stability of dielectric
properties of the Ce-doped SBT. Impedance analysis revealed that the
conduction mechanism of the Ce-doped SrBi4Ti4O15 ceramics is mainly grain
conduction.
Influence of Co ion doping on the microstructure, magnetic and dielectric properties of Ni1-xCoxFe2O4 ceramics
Authors: Zou Jihua , Gao Rongli , Fu Chunlin , Cai Wei , Chen Gang , Deng Xiaoling
Published: January 2019

Ni1-xCoxFe2O4 (x = 0, 0.2, 0.4, 0.6, 0.8) ceramics were prepared by chemical
co-precipitation method and the effect of Co ion doping on the
microstructure, magnetic and dielectric properties has been investigated.
The results show that the synthesized ceramics display only spinel phase of
Ni1-xCoxFe2O4, without other apparent impurities found. The lattice of
Ni1-xCoxFe2O4 crystal structure was distorted as a result of the
incorporation of Co ion, and the lattice parameters increase with the
increase of Co ion content. The grain size decreases slightly with
increasing the content of Co ion, indicating a change of particle size and
morphology at higher doping content. The results of impedance analysis shows
that the sample doped with 80 at.%Co possesses the maximal dielectric
constant, while the pure NiFe2O4 sample shows the minimal value when the
frequency is below 0.1MHz. The M-H loops of these ceramics exhibit highly
magnetic nature and the saturation magnetization. The remnant magnetization
increases linearly with the increase of Co-concentration in nickel ferrite
while the coercive field (Hc) shows non-monotonic variation with Co content.
The minimal and maximal values of Hc can be obtained when the Co
concentrations are 40 and 80 at.%, respectively. The highest value of the
saturation magnetization is 63 emu/g obtained with 80 at.% Co doping while
the lowest value is ~31 emu/g for the pure NiFe2O4 ceramics. The abnormal
magnetic behaviour is due to the A-B super exchange interaction when
magnetic Co2+ ions are added.
Examination of milled h-BN addition on sintered Si3N4/h-BN ceramic composites
Authors: Balázsi Katalin , Furko Mónika , Fogarassy Zsolt , Balázsi Csaba
Published: January 2019

Silicon nitride (Si3N4) ceramics containing 1 and 5 wt.% of hexagonal boron
nitride (h-BN) were prepared by attrition milling and hot-isostatic
pressing. Thorough morphological characterizations have been carried out to
reveal the influence of the milling parameters on the size of the h-BN
additives. The results confirmed significant decrease in h-BN particle size
by increasing milling time. The transmission electron microscopy
observations revealed that the h-BN particles were incorporated into the
ceramic matrix. The results showed that the increase of the h-BN content
decreased significantly the hardness of materials. Moreover, the hardness
values were higher when the size of h-BN was larger. The same tendency was
observed in the case of Young?s modulus.
Kasner type magnetized string cosmological models in f(R,T) gravity
Authors: Hatkar S.P. , Gore S.V. , Katore S.D.
Published: January 2019

The Bianchi-I Kasner type metric with cosmic string and magnetic field in the
framework of the f(R,T) theory of gravitation is considered. Three
different functional forms of the function f(R,T) are chosen for
investigation. We found that the strings exist in early stages of evolution
of the Universe and they disappear as time increases. The variation of the
equation of state (EoS) parameter ? = p/?<-1 may come from the effect of
the string. We find that the string tension and rest energy density reduce in
presence of magnetic field. The Universe is expanding and accelerating.
Supporting Parents’ Informed Early Childhood Education and Care Choices through Playgroups
Authors: Stratigos Tina , Fenech Marianne
Published: January 2019

PROVIDING INFORMATION TO FAMILIES about quality early childhood education and care (ECEC) is important for supporting informed choices. The Australian Government has attempted to build parents’ capacity to make informed choices through the National Quality Framework and the National Quality Standard (NQS) rating system. Many families, however, have limited or no knowledge or understanding of the NQS. This study investigated the potential of playgroups as a site for raising awareness about quality ECEC and the NQS ratings among families. Semi-structured interviews were conducted with six supported playgroup coordinators, and focus groups were held with families from seven playgroups. Findings suggest that playgroups could be an effective avenue for disseminating information about quality ECEC. For supported playgroups, the informal and trusted approach of the playgroup coordinator may play an important role in raising awareness about quality ECEC, and they could be better supported in this role through accurate, up-to-date information and resources that are respectful of families’ diverse backgrounds and needs.
The state of musculoskeletal system in children cured of cancery
Authors: Krutikova N. Yu. , Yudenkova O. A.
Published: January 2019

Successful implementation of modern treatment modalities for children with oncological and hematological diseases resulted in significant increase in overall and relapse-free survival. These patients are at risk of developing musculoskeletal late effects. The assessment of musculoskeletal late effects and mineral metabolism and the development of solutions for comprehensive rehabilitation and prevention of late effects are challenging issues for pediatrics. A literature review summarizes information related to musculoskeletal late effects associated with special treatment and demonstrates a need for the optimization of diagnostic approaches and corrective therapy of mineral metabolism. Up-to-date multidisciplinary rehabilitation treatment for children in remission can correct the consequences of their main disease and treatment-related side effects.
Successful thoracoscopic esophageal leiomyomectomy in an adolescent
Authors: Ivanova N. N. , Talypov S. R. , Roshin V. Ju. , Akhaladze D. G.
Published: January 2019

Leiomyoma of oesophagus is a rare tumour in adults and even more rare finding in pediatrics. Biopsy or enucleation of tumour is necessary to exclude malignancy, especially in a case of any malignancy symptoms, for example, severe weight loss. Total excision of benign tumour is curative. In our report we present the clinical case of successful thoracoscopic excision of esophageal leiomyoma in adolescent.
GEOARKEOLOGI CEKUNGAN SOA, FLORES, NUSA TENGGARA TIMUR
Authors: Intan Fadhlan S
Published: January 2019

Soa Basin, which belongs to Ngada Regency and Nagekeo Regency, is located on Flores Island, with many cultural stays, among others, from the Paleolithic period, which has not been too concerned by environmental researchers, especially geoarkeology. This is the issue that covers general geological conditions. The purpose of this research is to mapping the surface geology in general as an effort to present geological information related to archeological site. The aim is to know the geomorphological, stratigraphic aspects of the archaeological sites. The research method is done through literature review, survey, field data analysis and interpretation. Environmental observations provide information on the landscape of the study area consisting of terrestrial morphology units, and weak wavy morphology units. The river is centripetal flow pattern, with the old river, mature-old river, periodic/permanent river, and episodik /intermittent river. Constituent rocks are volcanic breccias, tuffs, conglomerates, and alluvial deposits. The geological structure is a fracture of the normal fault type. Exploration in the Soa Basin has listed 12 paleolithic sites. From the classification of petrology, litik tools made of jasper, chert, andesite, and basalt rocks. Rock as a raw material litik, found in Soa Basin and surrounding areas, both in the form of outcrops and boulder.
Effect of Solid-State Fermentation on Main Nutritional Components, Some Minerals, Condensed Tannin and Phenolic Compounds of Olive Leaves
Authors: Altop Aydın
Published: January 2019

This study was carried out to investigate the effects of solid-state fermentation (SSF) on main nutritional components, some minerals, condensed tannin and phenolic compounds of olive leaves. Two groups were formed as a fermented (FOL, Aspergillus niger ATCC 52172) and non-fermented olive leaves (OL). Suitable environmental conditions (humidity, temperature and pH) before SSF were established and fermentation lasted on day 8. After fermentation, while the crude fiber, neutral detergent fibre (NDF) and acid detergent fibre (ADF) content of FOL compared to OL were decreased, its the crude protein, ether extract, ash and condensed tannin contents were increased. Some macro minerals (Ca, N, K, P, Mg) and micro minerals components (Fe, Mn, Zn, Cu, B) of FOL and OL were varied. Although oleuropein content of FOL was decreased, it‘s catechin and hydroxytyrosol contents were increased by SSF. These results showed that A. niger ATCC 52172 strain could be suitable inoculant to improve the nutritional content of olive leaves.
Amatör İç Su Balıkçılarının Sosyo-Demografik Özellikleri: Türkiye Örneği
Authors: Ateşşahin Tuncay , Cilbiz Mehmet
Published: January 2019

Bu çalışma, iç sulardaki amatör balıkçıların bazı sosyo-demografik özelliklerini belirlemek amacıyla, sosyal bir platformda interaktif olarak yürütülmüştür. Verilerin toplanmasında, 24 sorudan oluşan çevrimiçi bir anket formu kullanılmıştır. Ankette amatör balıkçılara yöneltilen sorular diğer çalışmalarla paralellik gösterecek şekilde hazırlanmıştır. Online ankete toplamda 2045 kişi katılmış ve Türkiye‘nin 71 farklı ilinden katılım gerçekleşmiştir. Ankete katılan amatör balıkçıların büyük bir bölümünü erkek balıkçılar oluşmaktadır (%99,9). Balıkçıların meslek dağılımlarına bakıldığında işsizliğin yaygın olduğu görülmüştür (%41,7). Genelde emekli uğraşı olarak değerlendirilen olta balıkçılığının bu çalışmada emekliler arasında çok yaygın çıkmamasının sebebi olarak anketin interaktif olarak uygulanması gösterilebilir. Bu düşünceyi destekler şekilde, ankete katılanların %76,7‘sı 25-46 yaş aralığındadır. Çoğunluğu (%76,7) bekâr olan oltacıların, ortalama aylık gelirleri 2845 â‚º‘dir. %51,2‘sinin aylık geliri 1500-3000 â‚º aralığındadır. Amatör balıkçıların çoğunluğu (%40,6) lise mezunudur ve %41,5‘lık kısmı üniversite (ön lisans, lisans ve yüksek lisans) eğitimi almıştır. Çalışmamıza dâhil olan amatör balıkçıların eğitim düzeylerinin, Türkiye‘nin birçok göl ve baraj gölündeki ticari balıkçılardan daha yüksek olduğu söylenebilir.
SISTEM PAKAR DIAGNOSA PENYAKIT PULPITIS PADA GIGI DENGAN MENGGUNAKAN METODE CERTAINTY FACTOR
Authors: Antika Elly , Lesmana I Putu Dody , Hindayati Annisa Sri
Published: January 2019

Pulpitis adalah peradangan pada pulpa gigi yang menimbulkan rasa nyeri. Pulpa adalah bagian gigi paling dalam, yang mengandung pembuluh darah dan saraf. Dalam pendiagnosaan penyakit ini, banyak sekali orang yang salah mengartikannya dengan penyakit gigi sensitive. Penyakit gigi pulpitis dapat diketahui melalui tes gejala fisik, foto rongen, dan gejala yang muncul saat diberi rangsangan. Namun untuk memeriksakan gigi kepada pakar gigi secara teratur merupakan suatu hal yang jarang dilakukan oleh sebagian orang, karena alasan-alasan tertentu. Oleh karena itu dibuatlah sistem pakar untuk mendiagnosa penyakit pulpitis pada gigi.Metode yang digunakan dalam sistem pakar diganosa penyakit pulpitis pada gigi ini adalah Certainty Factor. Certanty Factor ini dipilih karena metode ini paling cocok untuk digunakan untuk memberikan kemungkinan diagnosa terhadap suatu penyakit. Di dalam certanty factor terdapat tiga proses yaitu pengumpulan atau pemberian nilai kepercayaan (MB) dan ketidak percayaan (MD), pengklasifikasian atau pengkombinasian antara penyakit dengan gejala yang timbul, dan perhitungan nilai kepastian terhadap suatu gejala terhadap suatu penyakit. Dari semua tahapan yang telah dilakukan dengan sistem pakar menggunakan metode certanty factor, dapat diketahui hasil akhirnya yaitu semakin tinggi atau besar nilai kepastian, maka seseorang tersebut dapat diketahui terdiagnosa suatu penyakit tersebut.
HUBUNGAN PEMBERIAN MAKANAN TAMBAHAN-PEMULIHAN DENGAN KADAR HEMOGLOBIN DAN KENAIKAN BERAT BADAN IBU HAMIL KURANG ENERGI KRONIS (STUDI DI WILAYAH KERJA PUSKESMAS JELBUK KABUPATEN JEMBER)
Authors: Amareta Dahlia Indah
Published: January 2019

Gizi ibu yang buruk sebelum maupun saat kehamilan akan berisiko melahirkan bayi dengan BBLR, gangguan pertumbuhan dan perkembangan otak bayi, serta risiko kesakitan dan kematian. Salah satu upaya yang dilakukan dalam menurunkan angka BBLR adalah dengan PMT-Pemulihan pada ibu hamil KEK. Tujuan penelitian menganalisis hubungan antara PMT-Pemulihan dengan kenaikan berat badan dan kadar Hb pada ibu hamil KEK.Penelitian ini merupakan penelitian analitik dengan desain cross sectional, melibatkan subjek penelitian sejumlah 38 orang ibu hamil KEK. Variabel bebas adalah PMT-Pemulihan pada ibu hamil KEK, variabel terikat meliputi kenaikan berat badan dan kadar Hb. Uji hubungan dilakukan dengan menggunakan uji Kruskal wallis pada taraf signifikansi 0,05.Hasil penelitian menunjukkan responden berada pada rentang umur 14-37 tahun dengan rerata 20,45 tahun, LILA berada pada rentang 20-23 cm dengan nilai rerata 21,87Â±1,0 cm. Paritas bervariasi mulai 1 hingga 4. Rerata kenaikan berat badan trimester 3 yaitu 4,48Â±3,2 kg dengan kenaikan tertinggi sebesar 12 kg dan nilai terrendah yaitu -0,5 kg artinya terdapat penurunan berat badan sebesar 0,5 kg. Simpulan penelitian ini adalah terdapat hubungan antara PMT-Pemulihan dengan kenaikan berat badan ibu hamil KEK (p=0,007), tidak terdapat hubungan antara PMT-Pemulihan dengan kadar Hb (p=0,097).Â
ANALISIS FAKTOR INTERNAL DAN EKSTERNAL YANG MEMPENGARUHI PENGEMBANGAN AGRIBISNIS TEMBAKAU DI KABUPATEN JEMBER
Authors: Ardhiarisca Oryza , Muspita Merry , Kustiasari Tanti
Published: January 2019

Salah satu kabupaten di jawa timur yang berperan sebagai penghasil terbesar dalam bidang pertembakauan adalah kabupaten jember. Sebagai kabupaten yang menghasilkan tembakau terbesar, perlu dilakukan pengembangan terhadap industri tembakau. Dalam proses pengembangan tersebut perlu dilakukan identifikasi dan analisa terhadap faktor internal dan eksternal yang dapat mempengaruhi industri pertembakauan. Dalam mengidentifikasi dan menganalisa faktor-faktor tersebut digunakan metode analisis deskriptif. Data dalam penelitian diperoleh dengan menggunakan kuesioner, wawancara, dan studi literatur. Kabupaten Jember untuk mengembangkan tembakau adalah sarana prasarana, peran APTI, peran kelompok tani, pemasaran, pembinaan, dan budaya tanam tembakau. Sedangkan yang menjadi kelemahan Kabupaten Jember adalah perubahan anomali iklim, pengetahuan teknis petani, hama penyakit, permodalan, dan penentuan harga oleh perusahaan. Peluang dari luar adalah permintaan pasar, DBH-CHT, dan perkembangan teknologi informasi sedangkan ancamannya adalah persaingan dengan daerah lain.
ANALISIS PENGAWASAN DAN KOMPETENSI TERHADAP KEPUASAN KERJA KARYAWAN MELALUI KINERJA PADA PT. EAST WEST SEED INDONESIA
Authors: Sihombing Fitria Agustina , Muspita Merry , Iskandar Ridwan
Published: January 2019

Perusahaan PT. East West Seed Indonesia adalah perusahaan terbesar dalam bidang produksi benih sayuran lokal di Indonesia. Perusahaan ini memiliki tenaga ahli dalam perkembangan produksi benih dan menciptakan benih â€“ benih sayuran unggul, memiliki mitra dan karyawan yang siap dan mampu dalam meningkatkan kinerja perusahaan, maka dari itu penting bagi perusahaan agar dapat terus memperhatikan dan peduli akan sumber daya manusia, khususnya karyawan yang memiliki kontribusi akan keberhasilan perusahaan dengan cara meningkatkan kepuasan kerja karyawan akan pekerjaannya.Â  Tujuan penelitian untuk mengetahui faktor-faktor yang mempengaruhi kepuasan kerja karyawan PT. East West Seed dengan kinerja sebagai variabel antara. Penelitian ini merupakan penelitian penjelasan dengan menggunakan analisis SEM. Hasil penelitian ini menunjukkan bahwa pengawasan berpengaruh secara langsung dan signfikan terhadap kepuasan kerja, kompetensi berpengaruh secara langsung dan signfikan terhadap kinerja, kemudian kinerja berpengaruh secara langsung dan signifikan terhadap kepuasan kerja karyawan, pengawasan tidak berpengaruh signifikan terhadap kinerja namun kompetensi berpengaruh signifikan terhadap kinerja, jika kinerja sebagai variabel antara sedangkan kompetensi tidak berpengaruh signifikan terhadap kepuasan kerja karyawan baik melalui variabel kinerja maupun tidak melalui variabel kinerja. Berdasarkan hasil analisis dan pembahasan tentang analisis pengawasan dan kompetensiÂ  melalu kinerja terhadap kepuasan kerjaÂ  karyawan PT. East West Seed Indonesia, maka dapat ditarik kesimpulan sebagai berikut: Pengawasan tidakÂ  berpengaruhÂ  signfikan terhadap kinerja karyawan PT. East West Seed Indonesia dengan nilai CR= 0,870 dan P value= 0.384. Kompetensi berpengaruh signifikan terhadap kinerja karyawan PT. East West Seed Indonesia dengan nilai CR= 7,456 dan P value= 0.000. Pengawasan berpengaruh langsung dan signifikan terhadap kepuasan kerja karyawan PT. East West Seed Indonesia dengan nilai CR= 3,300 dan P value= 0.000. Kompetensi tidak berpengaruh signifikan terhadap kepuasan kerja karyawan PT. East West Seed Indonesia dengan nilai CR=-0,114 dan P value= 0,909. Â Kinerja berpengaruh signifikan terhadap kepuasan kerja karyawan PT. East West Seed Indonesia dengan nilai CR= 3,085 dan P value= 0.002.
Pengaruh Interval Waktu Pemberian Pupuk Organik Cair Berbahan Baku Keong Mas Terhadap Pertumbuhan dan Produksi Hijauan Pennisetum purpureum cv. Mott
Authors: Sada Silvester Muga , Koten Bernadete Barek , Ndoen Bernadus , Paga Agustinus , Toe Paskalis , Wea Redempta , Ariyanto Ariyanto
Published: January 2019

The research with aim to assessing the effect of givingÂ  time interval of organic liquid fertilizer made golden snail aplle on growth and forage production Pennisetum purpureum cv. Mott, has been held for 3 months at the Kupang State Agricultural Polytechnic gardens forage at Oesao. The study was designed by Randomized Block Design, with 5 treatments and 5 block, which consists of the P0: without organic liquid fertilizer, P5: every 5 days, P7: every 7 days, P9: every 9 days , P11: every 11 days. The variables are number of shoots (number/ week), high gain (cm/ week), production of fresh weight (tons/ ha), dry matter production of forage (tons/ ha). Analysis of variance showed that the interval timing of organic liquid fertilizer made of snailsÂ  no significantÂ  effect (P>0.05) to number of shoots, high gain,Â Â  fresh weight production of forage, andÂ  dry matter production of forage. The average of number of shoots are 10.11/ week (P0: 10.46; P5: 11.35; P7: 10.41; P9: 9.39; P11: 8.94), the increase plant height 20.90 cm/ week (P0: 21.06; P5: 22.01; P7: 21.20; P9: 20.61; P11: 19.60), 53.32 tonnes / ha the fresh production of forage (P0: 53.62; P5: 57.71; P7: 49.39; P9: 55.18; P11: 50.71), 7.73 tonnes/ ha of dry matter of forage (P0: 7.72; P5: 8.80; P7: 7.17; P9: 7.68; P11: 7.26).Â  It was concluded that the growth and forage production of Pennisetum purpureum cv. Mott is not be effected ofÂ  effect of time interval of liquid organic fertilizer made from raw of golden snail.
Mampu Bentuk Briket Variasi Bahan Briket Dengan Komposisi Perekat Serta Waktu Pencelupan Minyak Jelantah
Authors: Nurhilal Mohammad
Published: January 2019

AbstractIndonesia is given Â with abundant natural wealth which is capable of being transformed into source of energy. However, the utilization of these natural resources can not yet be optimized. An alternative solution to make fuel is briquette fuel. The general purpose of this research is to make briquettes of rice husk and garlic skin. While the specific purpose of this research is to know the result of briquette variation of adhesive material and briquette material with adhesive as well as time of reused oil dipping. The method of this research is experiment approach. The results showed that starch glue can be used as briquettes of rice husk and garlic skin; mixed variations of 60%, 70% and 80% starch glue blends were able to form briquettes; variations of pulp mixture 20%, 30% and 40% and without mixing the pulp can form briquettes; and the variation of briquette dyeing time of 1, 3, and 5 minutes had no effect on briquette solidity.Â Keywords: Briquette, rice husk charcoal, garlic skin charcoal, adhesive, solidity.
Neraca Massa, Komposisi Kimia dan Nilai Ekonomis PengolahanAgroindustri Glukomanan
Authors: Kurnianto M Fatoni , Hariono Budi , Hartati Sri
Published: January 2019

Uber Gadung (Dioscorea Hispida dennst) is a tuber plant that can produce glucomannan. Chemically, glucomannan is a non-ionic hydrochloric polysaccharide compound, having a high molecular weight of 9.0x105gmol-1atau2.7x105-1.1x106Dalton. The current problem is not done to the mass balance calculation at the end of the product being the processing base at the agroindustry level. The study consists of 3 main stages, including: (i) sampling; (ii) Product fractionation and drying; (iii) Economic extraction and calculation. The results showed that the calculation of the mass balance of treatment difference in mesh size gives the result that the larger the size (smaller particle size), resulting in less glucomannan. The fraction of glucomannan flour which passes 40-60 mesh sieve produces the highest glucomannan content compared to other particle size. The particle size treatment has significant effect on glucomannan, starch, crude fiber, water, density of kamba, viscosity, pH, and weight percentage. The highest yield is found in 40-60 mesh flour mung, while the highest starch and crude fiber content is in the size <100mesh. The highest added value is obtained from the processing into glucomannan with the value of Rp 650.000 / 100kg, as well as the profit of 86.67 percent. While the value of the lowest profits on the processing of gadung tuber into a dry chip.Â Keywords : Uber Gadung, glucomannan, dry chip