bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of efficiency and safety of Olatropil medication in complex treatment of discirculatory encephalopathy in patients with arterial hypertension
Authors: В. І. Величко  , Г. О. Данильчук  , Г. В. Корнован  , С. Ф. Коваленко  , О. М. Балабан
Published: December 2018

The article is devoted to the actual problem of modernity – chronic cerebrovascular pathology. The data on efficacy of therapy with combined nootropic Olatropyl are presented in comparison with piracetam in patients with chronic brain ischaemia due to arterial hypertension and cerebral atherosclerosis.The objective: study of effectiveness and safety of Olatropil in complex treatment of dyscirculatory encephalopathy in patients with arterial hypertension.Materials and methods. Sixty patients (men and women) with arterial hypertension (AH) and signs of discirculatory encephalopathy (DEP) of I and II degree aged from 46 to 65 years were examined. All patients were divided into two statistically homogeneous groups (main and control) of 30 people each. Patients of both groups received antihypertensive medications during diet therapy. Patients of the main group in addition to the basic therapy took Olatropil, and patients of control – piracetam.Results. Analysis of the results of the investigation showed that in patients of the main group who received Olatropil, compared with the control group, there was a significant decrease in clinical manifestations of AH, decrease in severity of asthenoneurotic syndrome, anxiety, improvement of cognitive functions, and increase of cerebral blood flow. During the investigation Olatropil demonstrated a favorable safety and tolerability profile.Conclusion. Inclusion combined medication Olatropil in complex therapy of dyscirculatory encephalopathy in patients with arterial hypertension provides more pronounced therapeutic effect due to its neurometabolic, nootropic, vasoconstrictive and antihypoxic action.
Early evaluation of the development of cardiovascular pathology in asymptomatic patients with subclinical hypothyroidism
Authors: О. Г. Шекера  , Х. М. Кухарчук
Published: December 2018

To date, the issue of the influence of subclinical hypothyroidism on the development and progression of cardiovascular disease is very actively discussed. The importance of this pathology is due to the fact that during the first year, 5–15% of cases of subclinical hypothyroidism go into a manifestation with the development of cardiovascular complications in 70–80% of patients. According to various authors, cardiovascular lesions are observed in the majority (in 70–82%) of patients with hypothyroidism and often the first manifestation of the disease. And clinical manifestations of cardiovascular pathology in patients with subclinical hypothyroidism occur in 25–50% of patients. In the works on subclinical hypothyroidism, signs of glucose metabolic disorders have also been identified, which is also a cardiovascular risk factor.The objective: evaluation of methods for individual prediction and targeted early detection of cardiovascular risk in people with subclinical hypothyroidism.Materials and methods. An analytical review of scientific publications using the search engine JAMA, Scholar and PubMed has been conducted over the past 10 years.Results. Scale SCORE allows you to quickly and easily assess the overall risk of cardiovascular mortality for each person, as well as predict its dynamics in the future and identify specific ways to reduce it. Scale PROCAM is a method of calculating the global ten-year risk of coronary artery disease in women and men. ASSIGN scale a 10-year risk of developing cardiovascular disease, including death from cardiovascular disease, CHD, cerebrovascular disease at discharge, or coronary artery intervention. The Reynolds risk scale estimates the 10-year total risk of cardiovascular events (MI, ischemic stroke, coronary artery revascularization, and death from cardiovascular disease). Score Framingham scale allows us to assess the 10-year risk of developing cardiovascular events in individuals who do not have clinical manifestations of cardiovascular disease.Conclusion. The use score in patients with subclinical hypothyroidism without symptoms of cardiovascular lesions will allow doctors to improve preventive measures in people at high risk of developing cardiovascular disease.
Experience in the use of Noophen® 500 in patients with stable angina and gastroesophageal reflux disease in preparation for esophagogastroduodenofibroscopy
Authors: О. С. Хухліна  , В. Ю. Дрозд
Published: December 2018

The objective: was to determine the frequency of cardiac symptoms in patients with stable angina pectoris with co-morbidity with gastroesophageal reflux disease (GERD) in the course of esophagogastroduodenofibroscopy (EHDS), determining the efficacy of Noophen®500 in order to prevent the development of cardiac symptoms of CHF, anxiety symptoms that may occur during ECGDS.Materials and methods. 89 patients with HF, I-II FC with comorbid endoscopically positive GERD (A, B, C) were examined. Two representative groups of the study were formed: group 1 (main group) – 45 patients who received a 500 mg dose of Noophen® 500 for a premedication, once a day, on the eve of EGGFS 2 hours before bedtime; 2nd (control) group – 44 patients who did not receive premedication. Endoscopic examination was carried out in the morning, on an empty stomach, 1 hour after awakening, under ECG monitoring. All patients before the use of the drug for 1 hour before the endoscopic examination and 1 hour after it, it was suggested to pass the tests of C.D. Spielberger and Yu.L. Hanina, and SUN. When conducting the efGDS, the possible effect of the drug on the technique of carrying out the endoscopic study was evaluated, and after diagnosis, the degree of satisfaction with the studies was determined in the patients surveyed.Results. A single application of Noophen® 500 can be recommended to prevent the occurrence of negative cardiac events during the endoscopic diagnosis, reduce the level of anxiety of patients, and provide a more comfortable diagnosis. Does not affect the state of sphincters, secretory and peristaltic activity of the digestive tract, facilitates the conduct of this diagnostic study for both the patient and the doctor.Сonclusion. The use of Noophen® 500 for the purpose of premedication provides an easy tranquilizing effect, anxiolytic, normotimic and moderate activating effects, improves mood, well-being and does not cause retardation, drowsiness, a feeling of exhaustion, and does not adversely affect the course of comorbid pathologies.
Platelet autologous plasma for the treatment of posttraumatic osteoarthritis and knee injury: clinical findings of 12 months follow-up
Authors: Г. О. Гаврилюк
Published: December 2018

Osteoarthritis (OA) is the most common form of arthritis in the world. In the general structure of morbidity, the portion of OA is 12%. The main reason for the development of secondary knee OA in young patients is traumatic injury, which leads to the gradual degradation of the articular cartilage with the development of symptomatic OA in the first 3-5 years after injury.The objective: to investigate the clinical safety and efficacy of platelet autologous plasma (PAP) comparing to standard treatment in young patients with symptomatic post-traumatic knee OA (PTOA) and in the early period after the knee injury.Materials and methods. The stady included 122 patients (mean age 34,81±4,28 years), 62 – with established symptomatic PTOA (mean time from trauma –46,87±2,09 months), and 60 – in early period after intra-articular knee trauma (confirmed by MRI, 20,15±1,72 days after injury). Patients with established PTOA and knee trauma were divided in 2 groups – Gr.1 received standard treatment (NSAIDs, exercises, complex physical therapy for patients with PTOA and NSAIDs, complex physical therapy for patients with knee trauma), Gr.2 –in addition to the standard treatment received course of 3 intra-articular injections of PAP. Efficacy of treatment in both group was evaluated by standard recommended scales (KOOS questionnaire (Knee injury and Osteoarthritis Outcome Score) and VAS pain score (Visual Analogue Scale).Results. Patients of both groups with PTOA demonstrated positive dynamics of clinical manifestations of OA and functional activity, which affected the improvement of KOOS parameters. However, Gr.2 showed better results compared to Gr.1. During the follow-up period, in both groups of patients with knee injury, positive dynamics were observed for all KOOS subscales. However, the functional state of patients who received intraarticular PAP injection had a more significant dynamic, accompanied by significant differences in indicators with repeated monitoring.Conclusions. Use of the intraarticular injections of PAP for the treatment of symptomatic knee PTOA, as well as in the early period after a knee injury is safe and effitient part of the complex therapy, which improves both early and long-term results of the treatment. In patients with PTOA, PAP use allows to reduce the number of exacerbations arthritis within 12 months. In patients after knee trauma PAP use accelerates the improvement in the functional activity comparing to treatment with standard therapy.
Hyperhemolysis syndrome: theory and practice
Authors: С. В. Видиборець  , С. М. Гайдукова  , О. В. Кучер  , Г. І. Мороз
Published: December 2018

The article dead with detailed information about etiology, pathogenesis, clinical sings, prophylactics and treatment of complication of blood transfusions of hyperhemolysis. Hyperhemolysis syndrome is a severe complication of blood transfusions in patients of different age, more incident in the sickle cell disease and thalasemia, but occuring also in other conditions, for example, lymphomas, anemia of chronic disease. The phathogenesis of thys syndrome remains not amply studied and there are no unambiguous recommendations on its treatment. This review of the revelant publications present the probable mechanisms of development, clinical cases and their treatment.
Effect of Tivorel on the level of matrix metalloproteinases-2 and 9, galectin-3, final glycation products and functional state of the endothelium in patients with postinfarction chronic heart failure with preserved ejection fraction
Authors: О. В. Курята  , А. Забіда  , О. Ю. Сіренко
Published: December 2018

The objective: to evaluate the effect of Tivor-L (20 mg levocarnitine + 42 mg arginine hydrochloride, Yuriya-Pharm) on AGEs, galectin-3, MMP-2,9 serum level, cardiac haemodynamics and endothelial function in patients with post infarction HFpEF.Materials and methods. All individuals (35) included aged 40 to 80 years, 23 (66%) males and 12 (34%) females were diagnosed with (HFpEF) according to ESC guidelines (2016). First (1-st ) group (n=15) pts with postinfarction HFpEF treated with Tivor-L in addition to standard treatment for Chronic heart failure (CHF). Second (2nd) group (n=20) – pts with postinfarction HFpEF with standard treatment for CHF without Tivor-L. All the patients included in 1st group got Tivor-L intravenously daily for 10 days in addition to the conventional therapy. General biochemical blood analysis, complete blood count and glomerular filtration rate, MMP-2, MMP-9, galectin-3 and AGEs serum levels were determined before and after treatment.Results. Mean galectin-3 level in 1st was decreased by 16.4 % on the whole (p<0,05), in compare with standard therapy – no significant changes (p>0,05). significant decreasing of MMP-2, MMP-9 levels on 41% and 78,5% in 1st group (p<0,05). The FMD level was significantly higher in 1st group than in standard therapy group (p<0,05). Endothelial function normalizing was achieved in 10 (66%) of 1st group patients.Conclusion. Most of the pts with postinfarction HFpEF have increased AGEs serum level, and endothelial dysfunction. There were a significant decrease in galectin-3 and MMP-2, MMP-9 serum levels after adding of Tivor-L to the conventional treatment for chronic heart failure.
Clinical and Laboratory Efficacy and Safety of ValeVita Rinogel Spray and Nazo-Vit Use in Treatment of Children with Acute Postvirus Rhinosinusitis
Authors: Ю. В. Гавриленко
Published: December 2018

The objective: to evaluate the effectiveness of the therapeutic effect, the overall and local tolerance of ValeVita Rinogel Spray and ValeVita Nazo-Vit in treatment of children with acute postvirus rhinosinusitis (APRS).Materials and methods. The clinical study included 30 children (17 boys and 13 girls) who were on an outpatient treatment in ENT department of the city’s Children’s Clinical Hospital №1 in Kyiv. The age of patients ranged from 8 to 15 years old (mean age 11.5±0.5 years old). The main group of children (n=15) used ValeVita Rinogel Spray and ValeVita Nazo-Vit; the control group (n=15) used nasal decongestants (xylometazoline) and sodium chloride 0.9%. In children of both observed groups there were evaluated clinical symptoms of APRS, microbiological and cytomorphological studies of the nasal mucosa before and after the treatment.Results. According to the analysis of rhinoscopic and endoscopic examination there was a more rapid regress of clinical symptoms of APRS in children of the main group compared with the control group. Cytomorphological study in the main group noted a significant decrease of inflammatory cells (eosinophils, neutrophil granulocytes, lymphocytes) in nasal mucosa of children with APRS during treatment period compared with children of the control group. Combined use of ValeVita Rinogel Spray and ValeVita Nazo-Vit in the main group promoted normalization of immune clearance of nasal mucous lining as manifested by decrease of pathogenic organisms compared with the control group. During observation time no complications, side effects associated with the use of ValeVita Rinogel Spray and ValeVita Nazo-Vit were noted in patients.Conclusion. Combination of ValeVita Rinogel Spray and ValeVita Nazo-Vit is effective and safe in the treatment of acute postvirus rhinosinusitis in children 8-15 years old, does not cause local and general pathological changes, as evidenced by performed clinical and laboratory examination of patients.
Rational combined antibacterial therapy of the first line for treatment of patients with in-patient community-acquired pneumonia
Authors: Т. О. Перцева  , Т. В. Кірєєва  , К. О. Бєлослудцева  , М. А. Крихтіна
Published: December 2018

Given that community-acquired pneumonia (CAP) is a frequent disease, in which antibiotics are always prescribed, in foreign literature there are papers devoted to rationalizing of the choice of one-component or combination antibiotic therapy (ABT) in this pathology, as well as to optimize its terms appointment.The objective: to evaluate the efficacy, safety and rationality of the appointment of beta-lactam in combination with azithromycin (Chemomycin® from the manufacturer Hemofarm AD, Serbia) in patients with CAP of the third clinical group.Materials and methods. The study was attended by 25 patients the third clinical group of CAP, who were treated in the therapeutic and pulmonary departments of the city. After diagnosis, the patient was given a combined ABT: beta-lactam, namely, amoxicillin / clavulanate (at a dose of 1,2 g three times a day intravenously) or ceftriaxone (at a dose of 2 g once a day intravenously), and the macrolide, namely the preparation of azithromycin Chemomycin® from the manufacturer Hemofarm AD, Serbia (at a dose of 500 mg once daily orally).Results. As a result, all patients included in the study, found recovery. In the treatment of patients, there were no apparent clinical side effects of the drug. In addition, in patients with the presence of concomitant cardiology, the deterioration of the condition, the appearance of new changes and/or prolongation of the QT interval (clinically and according to the electrocardiogram) was not observed in any case.Conclusion. 1. The presence of a frequent concomitant pathology and false habits in hospitalized patients with CAP of our region is a risk factor for the presence of intracellular pathogens, as well as typical strains of respiratory pathogens producing beta-lactamase; this is an indication for the addition of macrolides (mainly azithromycin) to the first line ABT that acts on intracellular pathogens and destroys the Haemophilus influenzae biofilms.2. Integrated step-by-step antibiotics inpatients with CAP in the three-day oral azithromycin treatment program (Chemomycin®) significantly reduces the serum level of the systemic inflammation marker of CRP, is safe and highly effective.3. The drug Chemomycin® is well tolerated, it can be recommended as a drug of choice for conducting a complex first-line ABT for the patients with third clinical group of CAP.
Рlatelets: structure and function
Authors: С. В. Видиборець  , С. М. Гайдукова  , О. В. Мулярчук
Published: December 2018

A general characteristic of platelets. The article presents literature data of laboratory methods of couting platelets. The principles, advanages and disadvantages of counting platelets count. Special attention is paid to the study of automated platelet blood parameters and their interpretation. Provides information about the features of preanalytical phase of the study of platelet parameters usid hematology analyzers.
Аlbumin of serum: the range of possibilities for the application
Authors: С. В. Видиборець
Published: December 2018

An albumin is a basic albumin of organism. It’s possesses numerous irreplaceable functions. Preparations of albumin are utillized in intensive therapy, during operative interferences, at traumas, burns, diseases of buds, liver and other. An albumin is let in on the ground before other solutions for infusions. Discusses the international requirements to the technology of albumin preparation manufacture, the main controllable parameters of ready dosage form quality, and methods of control. Suggests alternative stabilizers for the manufacture of albumin preparations and quality control of additional parameters, the main of which is the functional activity (binding capacity, absorption capacity), directly determining the preparation efficiency.
Cardiovascular prevention
Authors: Л. В. Хіміон  , О. Б. Ященко  , С. В. Данилюк  , Т. О. Ситюк
Published: December 2018

The overview of the updated clinical guidelines on cardiovascular prevention and management of risk factors by family physician is given at the article.
Pseudo-abdominal syndrome in the practice of a general practitioner–family medicine
Authors: Л. С. Бабінець  , Б. О. Мігенько  , Н. І. Корильчук  , Н. Є. Боцюк  , Л. М. Мігенько  , Є. М. Стародуб  , О. Р. Ясній
Published: December 2018

A separate group of diseases accompanied by severe pain syndrome are diseases of the organs outside the abdominal cavity, but form a symptom complex similar to the acute abdomen – pseudo-abdominal syndrome. The article presents a list of such major pathologies that clinically simulate acute surgical diseases of the abdominal cavity, but unlike the diseases that make up the acute abdominal syndrome, an acute surgical intervention is not required in the pseudo-abdominal syndrome.
Alcohol consumption in patients with first diagnosed tuberculosis and its effect on the disease
Authors: I. I. Грек
Published: December 2018

The objective: determination of the alcohol consumption character and course of the infectious process in patients with first diagnosed tuberculosis (FDTB).Materials and methods. There are 52 patients with FDTB on continuation phase of treatment were investigated. Patients had a complete general clinical laboratory instrumental examination and test AUDIT. Treatment and monitoring were carried out in accordance with the order of the Ministry of Health of Ukraine No. 620 dated 04.09.2014 (UCPMD «Tuberculosis»).Results. 72% of patients with FDTB have alcohol consumption with a risk for their mental and physical health, of which 15,8% have a possible alcohol dependence. 88% patient had a non-compliance of treatment regimen and 15,4% of patients still had cavities after an intensive phase of treatment.Conclusion. Abuse of alcoholic beverages has a direct influence on the beginning and management of FDTB. The AUDIT test helps identify groups of patients who are consuming alcohol with risk for their physical and mental health.
Modern view on the risk factors for malignant tumors of the thyroid gland: a systematic review
Authors: В. І. Ткаченко  , Я. Ю. Рімар
Published: December 2018

The morbidity of thyroid carcinoma (TC) tends to annual growth. The results of the multifactorial studies of the development of thyroid carcinogenesis testify the insufficient knowledge about the influence and significance of certain TC factors, which requires systematization in order to improve the oncoepidemic situation in the country.The objective: of this study was to conduct an analytical systematic review of literature to resume risk factors of TC in the last 10 years.Materials and methods. The generalization of literary sources, founded by key words in Google Scholar, PubMed and eLIBRARY.ru for 2007 to 2017 was carried out. We analyzed the value of the odds ratio (OR), the relative risk (RR), the hazard ratio (HR), standardized incidence ratio (SIR) and an excess relative risk (ERR) with respective confidence intervals (95% CI), as well as the reliability value (p).Results. The most significant risk factors for TC are: ionizing radiation (increases the incidence in 1,3–5 times); previous thyroid disease (associated with TC in 30–94% cases, most goiter, adenoma and AIT – in 29,7%, OR=2,12; RR=1,4), heredity (presence of TC in I degree relatives increases the chance of occurrence in > 4-times), systemic autoimmune disease (SLE increases the risk 1,8 times), diabetes (TC risk increases on 18–20%), menstrual and reproductive factors (increased risk in 1,2–2,4 times), anthropometric factors (high height – increases the risk in 1,2–1,6 times, BMI ≥30 kg/m2 – in 1,35–1,7 times, and the waist >90 cm in women – in 1,3 times); benign breast disease (TC risk is higher on 38–56%), breast cancer (TC risk increases in 1,4–2,3 times), deficiency of vitamin D (TC risk increases 2–6 times), the persistence of virus, insufficient iodine intake, lifestyle – the use of certain products and physical activity, anthropogenic and occupational factors.Conclusion. The primary care physician should take into account the current understanding of the risk ТС factors in patients, especially in high-risk groups.
Ceramide as a risk factor of nonalcoholic fatty liver disease
Authors: Л. Л. Павловський  , В. В. Чернявський
Published: December 2018

At present, one of the factors of the pathogenesis of nonalcoholic fatty liver disease, which deserve particular attention, is the accumulation of specific lipid subspecies in the liver – ceramides. This article shows what the ceramides are, how they are formed, and how they influence on apoptosis and development of insulin.
Basic approaches to treatment of urinary tract infection in the practice of a family doctor
Authors: Л. Ф. Матюха  , Т. А. Титова
Published: December 2018

The objective: a comparative study was aimed at the study of the effectiveness and evaluation of the dynamics of clinical and laboratory parameters of therapy with oral antimicrobial Flaprox versus nitrofuran therapy in patients with exacerbation of chronic urinary tract infection in outpatient settings.Materials and methods. Тhe study included 40 patients (16 men, 24 women) with exacerbation of chronic pyelonephritis. Participants in the study were divided into 2 groups: 26 patients who received Flaprox 500 mg twice a day for 10 days in the main group (A), 14 patients in the control group (B) received nitrofuran 100 mg 4 once a day for 10 days. The mean age of the patients was 39,8±8,9 years.Results. The regression of clinical manifestations of urinary tract infection in the study process was noted in both groups. In the main group, the dynamics of reduction of symptoms of general intoxication and normalization of local symptoms and inflammatory changes in blood and urine has a more pronounced tendency from 5 days of treatment and persisted throughout the course of therapy.Conclusions. Flaprox useing for 10 days allowed to reliably reduce or eliminate dysuria, infection of the urinary tract (bacteriuria), and inflammatory process (leukocythria) without negative changes in the blood biochemistry analysis. Therapy of UTI with Flaprox demonstrates efficacy in comparison with the use of nitrofurans and the achievement of positive dynamics of clinical and laboratory parameters in a shorter time.
The clinical course of chemoresistant pulmonary tuberculosis in the dynamics of treatment depending on the genotypes of M. tuberculosis
Authors: А. В. Рогожин
Published: December 2018

The objective: to determine the features of clinical-laboratory and radiological dynamics in patients with chemoresistant pulmonary tuberculosis depending on genotypes of M. tuberculosis during the intensive phase of treatment.Materials and methods. In 135 patients with chemoresistant pulmonary tuberculosis were studied the clinical-laboratory and radiologocal dynamics depending on the genotypes of M. tuberculosis during the intensive phase of treatment. The patients were divided into two groups. Genotypes of M. Tuberculosis Beijing family (Beijing group) were found in 67,4% of patients, genotypes of the family LAM, Haarlem, Africanum and genotypes of individual profiles (non-Beijing group) were found in 32,6% of patients. Features of the clinical course dynamics of chemoresistant pulmonary tuberculosis were assessed by the dynamics of intoxication syndrome, closing of the lung parenchyma destruction and cessation of the bacterial excretion during the intensive phase of treatment.Results. Among patients of theBeijing group compared with no-Beijing group the positive clinical and radiographic dynamics is observed much less frequently. At the same time in the group ofBeijing patients there are significantly fewer people with the cessation of bacterial excretion and cases of healing of the pulmonary parenchyma destruction and more patients with an intoxication syndrome.Conclusion. Using of the VNTR molecular genetic method allows predicting the course and effectiveness of the treatment of chemoresistant pulmonary tuberculosis.
Self-improvement is the main factor in the success of a family doctor practice
Authors: М. А. Дудченко  , Н. Г. Третяк  , С. І. Сорокіна  , М. О. Дудченко
Published: December 2018

The family doctor’s profession is hard, tense and not always pleasant. The doctor does not know rest, no repose. He has no holidays, no weekend days. From the morning until late at night, and often all over the night, the doctor is among the suffering people.The quality of vocational training depends not so much on the congenital (type of nervous system, memory, etc.) as on the qualities acquired, such as general development, memory, humanism, charity, mastering of medical knowledge while studying at a university, etc.At the same time, the doctor must own the entire range of medical knowledge, be a cultured, educated intellectual, erudite in all spheres of human life.A creative physician must constantly engage in self-improvement with the aim to acquire professional experience, deep theoretical knowledge and practical skills using all available methods.
The prevention of cardiovascular diseases in old patients – state of problem
Authors: Ткаченко В. І. , Максимець Я. А.
Published: December 2018

Nowadays the WHO pays to the problem of ageing and health a lot of attention.The objective: to found out the features of prevention and management of cardiovascular diseases in elderly people.Materials and methods. A systematic analysis of 67 available literature sources and guidelines about management of cardiovascular diseases in old people received from JAMA, Scholar, NCBI, Cochrane Library and PubMed databases for the 2007–2017 with keywords related to the aim was conducted.Results. European and American guidelines have some recommendation for care of old people. Unfortunately, at presentUkraine doesn’t have specific protocols for the treatment of old patients. However, certain emphases are identified in National Unified clinical protocols of primary, emergency and secondary (specialized) medical care for hypertension, CVD and dyslipidemia.Conclusion. In accordance with Global Strategy and Action Plan of WHO it is necessary to develop more clear guidelines for care of old people, especially in prevention and management of cardio)vascular diseases.
Features of research of reflected pains in patients with multiple sclerosis
Authors: Г. М. Чуприна  , Н. К. Свиридова  , А. І. Галуша
Published: December 2018

Reflected pain (RP) is a variant of pain irradiation. In the case of pathology of internal organs, pain can spread to zones of certain dermatomes (viscero-sensory phenomenon), which are known as Zakharyin–Ged zones.The objective: to analyze the data of the study of the PR – Zakharin–Ged zones, carried out with the help of the Ged test in patients with multiple sclerosis (MS).Materials and methods. It was investigated in 216 patients with MS, using the classical H. Head sample, that in patients with MS, PR occur both from hypoesthesia zones and from areas of hyperesthesia, and in the arrangement of such zones is a definite system: they are associated with Zakharyin1Ged zones, where the PR is localized in pathology of internal organs.Results. The study of the Zakharyin–Ged zones revealed the presence of pain and the appearance of distant visceral pain sensations in 159 (73,6%) patients with MS of the general sample.Conclusions. The presence of hyperalgesia in the zones of Zakharyin–Ged and trigger points and also PR is systemic in nature and can provoke or intensify some neurological or somatic symptoms in MS patients.
Principles of immune correction of infeсtious complications following osteosynthesis of long bone
Authors: Н. О. Дехтяренко  , М. П. Грицай  , Г. Б. Колов
Published: December 2018

The objective: was to study the state of the immune system, analyze the dynamics of the parameters of immunological defense, evaluate the effectiveness of complex treatment with the inclusion of immunomodulating drugs to correct changes in immune defense, optimize the treatment of infection after osteosynthesis due to additional differentiated pharmacological immunocorrection.Materials and methods. 157 patients (113 men and 44 women) with infectious complications after osteosynthesis of long bones were examined. 78 of them had posttraumatic, and in 79 – postoperative osteomyelitis. Osteomyelitis of the femur was noted in 50 patients, tibia osteomyelitis – in 92 and upper limb – in 15 patients.Results. Multifactorial disorders in immune defense are established. It was found out that practically all immunotropic drugs that were used to treat patients with purulent complications after osteosynthesis of long bones showed to some extent a positive effect in terms of correcting the revealed disorders.Conclusion. The presented data became the basis for recommendations on the use of immunomodulating drugs for the prevention and treatment of purulent complications in patients after osteosynthesis of long bones, as well as for stimulation of reparative processes in violation of the rates of bone tissue regeneration.
Klinik örneklerden Campylobacter türlerinin üretilmesinin araştırılması ve antibiyotik duyarlılıklarının belirlenmesi
Authors: BORUCU Recep , TANRIVERDİ ÇAYCI Yeliz , BİRİNCİ Asuman
Published: December 2018

Amaç:
Campylobacter türleri
insanda sistemik infeksiyon ve ishallerin önemli sebeplerindendir. Bu
çalışmadaki amacımız Campylobacter
üretimini sağlamak için uygun besiyerini araştırmak ve üretilecek bakterilere
antimikrobiyal duyarlılık testleri çalışarak direnç profillerini tespit
etmektir. Yöntem:
Çalışmamıza 01 Mayıs - 01 Ekim 2016 tarihleri arasında ishal yakınması ile
başvuran hastalardan, mikrobiyoloji laboratuvarına kültür için gönderilen 405
gaita örneği çalışılmıştır. Campylobacter
üretimi için Modifiye Charcoal
Cephoperazone Deoxycholate Agar (mCCDA) ve Skirrow besiyeri olmak üzere iki farklı besiyeri
kullanılmıştır. Üreme görülen kültürlerdeki bakterilere konvansiyonel testler yapılmıştır
ve Campylobacter şüpheli olanların
Vitek MS ile tanımlaması yapılmıştır.Bulgular:
İncelenen 405 dışkı örneğinin dokuzunda Campylobacter
(%2,2) türü bakteri üremiştir. Bunların altısı Campylobacter jejuni, diğer üç tanesi ise Campylobacter coli olarak tanımlanmıştır. Elde edilen dokuz
izolatın yedisi (%77,8) kan bazlı Skirrow besiyerinde üremiştir. Bu yedi
izolattan ikisi aynı zamanda kömür bazlı mCCDA besiyerinde de üremiştir. İki
izolat (%22,2) ise sadece mCCDA besiyerinde üremiştir. İzole edilen dokuz Campylobacter türü izolata EUCAST kılavuzunun önerileri
doğrultusunda disk difüzyon yöntemiyle antibiyotik duyarlılığı çalışılmıştır. Test edilen antibiyotikler içinde
eritromisin en duyarlı (%77,7), siprofloksasin ise en dirençli (%77,7) olarak
bulunmuştur.Sonuç:
Besiyeri olarak kan bazlı besiyerinin kömür bazlı besiyerine göre daha iyi
üreme sağladığı görülmüştür. Antibiyotiklerden en duyarlı olarak bulunan
eritromisin’in ilk tercih olarak kullanılması ve yüksek bulunan kinolon
direncinin dikkate alınması gerektiği düşünülmektedir.
Василий Иванович Пономарев
Authors: Захаров А. Б.
Published: December 2018

25 июня 2018 г. исполнилось 60 лет известному ученому в области экологии, ихтиологии, охраны ирационального использования природных ресурсов, руководителю отдела экологии животных Института биологии Коми научного центра Уральского отделения Российской академии наук, кандидату биологических наук Василию Ивановичу Пономареву.
Светлана Владимировна Дёгтева
Authors: Чадин И. Ф. , Шубина Т. П.
Published: December 2018

21 сентября 2018 г. исполнилось 60 лет крупному ученому в области геоботаники, лесной типологии,охраны и рационального использования природных ресурсов, руководителю Института биологии Коми научного центра Уральского отделения Российской академии наук, доктору биологических наук Светлане Владимировне Дёгтевой.
Ученый, почвовед, географ, эколог. (К 100-летию со дня рождения Дмитрия Михайловича Рубцова)
Authors: Елькина Г. Я.
Published: December 2018

Д.М. Рубцов был в числе почвоведов, заложивших фундамент для составления первой почвенной карты Республики Коми М 1:1000000. Работы проводились по административным районам, по ряду районов составлены почвенные карты М 1:300000.
RESTRCTIONS OF PATENT
Authors: wahyuni Lidya
Published: December 2018

This article aimed at studying provisions in TRIPs Agreement and Law Number 14 of 2001 regarding Patent, particularly provisions reflecting criteria of public interest.The approach used is statutory and conceptual approaches by analysing TRIPs Agreement and Law Number 14 of 2001. It is concluded that public interest has been stipulated generally in TRIPs Agreement and Law Number 14 of 2001 in their provisions regarding kind and scope of the use of limitation and exception of patent holder’s exclusive rights. Law Number 14 of 2001 basically has implemented limitation and exception provisions stipulated in TRIPs Agreement. However, it does not provide further and clearer elaborations on some provisions that need to be elaborated further.Keywords: public interest, criteria, exception, limitation, patent.
Deliberate reasoning is not affected by language
Authors: Pfuhl Gerit , Mækelæ Martin Jensen
Published: December 2018

Background: Millions of people use a second language every day. Does this have an effect on their decision-making? Are decisions in a second language more deliberate? Two mechanisms have been proposed: reduced emotionality or increased deliberation. Most studies so far used problems where both mechanisms could contribute to a foreign language effect. Here, we aimed to identify whether deliberate reasoning increases for problems that are devoid of any emotional connotation when using a second language or having to switch between native and second language.Method: We measured deliberate reasoning with items from the cognitive reflection test, ratio bias, a probability matching task, and base rate neglect items. We recruited over 500 participants from Norway and the Netherlands that had English as their second language. Participants were randomly assigned to either the native, switching or second language condition. We measured: number of correctly answered items – deliberate reasoning score, perceived effort, perceived accuracy or confidence, and language proficiency.Results: Deliberate reasoning was not increased when using a second language or when having to switch between native and second language. All three groups performed equally well. Significant predictors of deliberate reasoning were age, gender, education, perceived effort, and confidence but not the language context. Participants with low English proficiency spent more time reading compared to more fluent speakers. Conclusion: There is no advantage of second language on deliberate reasoning in the absence of time pressure. Deliberation was not increased by providing items in a second language, but through the willingness to spend cognitive effort and time to read carefully.
QUIS HAKI
Authors: Septiawan Rully Nanang
Published: December 2018

Patent rights are special rights granted by the state to the inventor of the results of his invention in the field of technology, in which for the specified period of time carry out the invention itself or give approval to others to carry out it. This patent is granted for new inventions that contain inventive steps and can be applied in industry.This patent is exclusive because only inventors produce inventions that can be granted rights, but these inventors can carry out their own inventions or give approval to other parties to implement them, for example through a license.In Law No. 14 of 2001 Article 11, it is stated that those who are considered as inventors are individuals or some people who are declared as inventors for the first time in the application. So this patent right is not only owned by one person, but this right of peten can be given to several people against a discovery carried out jointly and on the patent registration application the names of the inventors are included. If the invention is found in cooperation, then the patent rights are held collectively.
Synthesis and characterization of a nano-scaled barium cerate perovskite powder using starch as polymerization agent
Authors: Köferstein Roberto
Published: December 2018

The preparation of nano-sized BaCeO3 powder using starch as a polymerizationagent is described herein. Phase evolution during the decomposition process of a (BaCe)-gelwas monitored by XRD. A phase-pure nano-sized BaCeO3 powder was obtained aftercalcining of the (BaCe)-gel at 920 °C. The resulting powder has a specific surface area of 15.4m2/g. TEM investigations reveal particles mainly in the size range of 30 to 65 nm. Theshrinkage and sintering behaviour of resulting powder compacts were studied in comparisonto a coarse-grained mixed-oxide BaCeO3 powder (SBET = 2.1 m2/g). Dilatometricmeasurements show that the beginning of shrinkage of compacts from the nano-sized powder is downshifted by 300 °C compared to mixed-oxide powder. Compacts from the nano-sizedpowder reach a relative density of 91 % after sintering at 1450 °C for 10 h.
My Project
Authors: VINOD K K
Published: December 2018

Breeding nutrient use efficient crop varieties has become a contemporary necessity to arm against the future threats in agriculture. This article comments on the necessity and ways to contemplate newer plant breeding strategies for this endeavor.
Identification and certification of Bactrian and Arvan camels of Kazakh population using DNA technology// FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2018. - С. 44-56.
Authors: Adil’bekova Elmira Kalybaevna , Alibaev Nuradin , Svitojus Arunas
Published: December 2018

Kazakhstan is the center where Bactrians and Dromedaries can be raised, and hybridization between them has become widespread. Genetic resources of interspecies camel hybrids, raised in Kazakhstan, are represented by 30 generations.The most highly valuable in the conditions of Central Asia and Kazakhstan are transboundary camel breeds such as Kazakh Bactrian, Turkmen and Kazakh Dromedary, as well as new generations of camels Arada, Bainar and Baitur.At pure breeding of Kazakh Bactrian, genetic peculiarities are not taken into account, in view of the poor knowledge of this issue. To maintain the biodiversity, molecular genetic monitoring of the state of camel populations is required. Cytogenetic monitoring and certification are one of the promising areas for reliable camel genome assessment.Deep determination of Kazakh dairy camelsallele poolwas not carried out in Kazakhstan before. Genetic studies to optimize structure, identification and certification of valuable genotypes, as well as systematization of genetic resources in dairy camel breeding in Kazakhstan are urgent task.The aim of the study is identification, systematization and certification of genetic resources of Bactrian and Dromedary camels of Kazakh population using DNA technology. Genetic analysis of the typing results of the camels studied was carried out by 7 and 8 loci of DNA microsatellites. The material for the studies was DNA samples isolated from histological samples. The microsatellite loci were selected in accordance with the recommendations of the European Society of Genetics (FAO/ISAG).Identification and certification of Arvan and Kazakh Bactrian camels’ genetic resources using the microsatellite analysis of their genotype was carried outfor the first time. Breeding significance of Bactrian and Arvan camels of Kazakh population using DNA technologies was studied and determined. The obtained results of the study allowed evaluate camels at the level of the allelic profile.
Специальные административные районы – российский офшор?// FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2018. - С. 8-12.
Authors: Алпатова Мария Григорьевна
Published: December 2018

В данной статье нами рассмотрен новый объект правового регулирования российского законодательства – специальный административный район. Для целей исследования важно определить: являются ли САР офшорными зонами в общепринятом понимании.In this article we consider a new object of legal regulation of the russian legislation – a special administrative region. For the purposes of the study, it is important to determine whether SAR are offshore zones in the conventional sense.
Polite speech emerges from competing social goals
Authors: Yoon Erica J. , Frank Michael C. , Tessler Michael Henry , Goodman Noah D.
Published: December 2018

Language is a remarkably efficient tool for transmitting information. Yet human speakers make statements that are inefficient, imprecise, or even contrary to their own beliefs, all in the service of being polite. What rational machinery underlies polite language use? Here, we show that polite speech emerges from the competition of three communicative goals: to convey information, to be kind, and to present oneself in a good light. We formalize this goal tradeoff using a probabilistic model of utterance production, which predicts human utterance choices in socially-sensitive situations with high quantitative accuracy, and we show that our full model is superior to its variants with subsets of the three goals. This utility-theoretic approach to speech acts takes a step towards explaining the richness and subtlety of social language use.
Validating Driver Profiles in the Daimler Traffic Simulation
Authors: Dablander Fabian
Published: December 2018

Driving simulators offer benefits such as a controlled, standardized, and thus replicable environment for experiments; ease of collecting highly accurate and precise measurements; and an overall high cost-effectiveness. To reap these benefits, however, driving simulation must be a valid measurement tool — behaviour observed in the simulation should generalize to the real road. Crucial for this is the behaviour of computer-generated drivers with which the driver interacts. The Daimler traffic simulation assumes, based on empirical studies, six distinct driver profiles. Does the behaviour of computer-generated drivers resemble human driving behaviour? Two experiments were conducted. In a simulation study, we tested whether we can recover the driver profile based on simulated driving data. While driver profiles were well separated in low and medium traffic scenarios, separation decreased in high traffic scenarios. These results are discussed and further studies suggested. In a driving simulator experiment, we tested whether the aggressive and calm driver profile improved upon an older version of the traffic simulation that lacked dedicated driver profiles. 32 participants had to judge whether the driver they encountered behaved like a human or computer, and had to provide realism judgements of its driving behaviour. Using Bayesian hierarchical regression methods, we found evidence that the driving behaviour of the aggressive driver is judged to stronger resemble human driving compared to the older version; other results were equivocal. I discuss these results and suggest improvements for future studies. Finally, in an online appendix, I discuss some of the exciting changes happening in scientific practice and culture. This includes a brief sketch of the “reproducibility crisis” in psychology, a tutorial on Bayesian statistics, and three practical recommendations for applied researchers.
Phytosociology of temperate forest at Tinjure-Milke-Jaljale (TMJ) area, Nepal
Authors: Niroula Bhabindra , Rai Shiva Kumar
Published: December 2018

Tinjure-Milke-Jaljale (TMJ) Conservation Area (Lat. 27°6ʹ57ʺ-27°30ʹ28ʺ N, Long. 87°19ʹ46ʺ -87°38ʹ14ʺ E; alt. 1700-5000 m; area 585.26 km2) lies between Arun and Tamor rivers in eastern Nepal. This area is popular for Rhododendron, the national flower of Nepal, and has been recognized by “The capital of Rhododendron”.
Plyometric basketball training
Authors: NİKOLİC Ana
Published: December 2018

Plyometric basketball training represents a widely used training method whose purpose is to resist the gravity force, meaning jump height improvement, better start acceleration, short section sprint, and direction change movement. The aim of this work was to analyze former plyometric basketball training researches, as well as to consolidate conclusions relevant to established work object analysis. This work covers 22 surveys published during a period from 2008 till 2018, which are shown in a chronological order and analyzed thoroughly. Obtained results suggest that fully planned and performed plyometric training within a defined time period has statistically significant positive effects on basketball explosive capacities development.