bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTATION OF GRANT DEEDS CONTAINING PROHIBITIONS ON WIFE GRANTS TO HUSBAND GRANTS MADE BY PPAT (STUDY OF SUPREME COURTDECISIONNUMBER 1893 K/PDT/2015)
Authors:   Law Faculty, Jenderal Soedirman University, Indonesia., Fatharani Sani , and Sulistyandari ,   Law Faculty, Jenderal Soedirman University, Indonesia., Wahyu Handayani Sri ,   Law Faculty, Jenderal Soedirman University, Indonesia.
Published: August 2024

Article 1678 of the Civil Code reads that it is forbidden to grant a husband and wife during the marriage period. The problem of this study is how to implement the Grant Deed, which contains a prohibition on giving wives to husbands based on the Supreme Court decision Number: 1893 K/Pdt/2015 and civil liability carried out by PPAT for negligence in PPATs obligations in terms of making grant deeds. This study aims to analyze the implementation of the Grant Deed, which contains a prohibition on the grant of wives to husbands based on the decision of the Supreme Court Number: 1893 K/Pdt/2015, and to analyze the civil liability carried out by PPAT for negligence in PPATs obligations in terms of making grant deeds. The type of research used is normative juridical, with the methods used being a legislative approach, a conceptual approach, and a case approach. The specification of this study uses a prescriptive. The data needed in this study is secondary data obtained from literature research, such as primary legal materials, secondary legal materials, and tertiary legal materials. The results of the study can be concluded that the application of the Grant Deed, which contains elements of the prohibition of wife grants to husbands based on the decision of the Supreme Court Number: 1893 K/Pdt/2015, namely, when viewed from the Denpasar District Court Decision Number: 723/Pdt.G/2013/PN.Dps, states that the conditions of the grant have been met, so the grant is valid. while if you look at the Decision of the Court of Appeal, namely the Decision of the High Court Number: 04/PDT/2015/PT. Dps, and Cassation Level Decision, namely Supreme Court Decision number: 1893 K/pdt/2015 stated that the grant was void or invalid because it violated the legal rules of Article 1678 of the Civil Code, as well as responsibility for PPATs negligence, namely civil liability and payment of compensation costs in the form of case costs.
BIBLIOMETRIC ANALYSIS OF IMPLEMENTATION TRENDS OF AUGMENTED REALITY TECHNOLOGY IN SCIENCE LEARNING
Authors:   Student of Magister Degree Program of Physics Education, Universitas Negeri Padang Jl. Prof. Dr. Hamka Air Tawar Barat Padang-25131, Indonesia., Maharani Zan Aprina , a Asrizal ,   Lecturer of Master Degree Program of Physics Education, Universitas Negeri Padang Jl. Prof. Dr. Hamka Air Tawar Barat Padang-25131, Indonesia.
Published: August 2024

Technological developments have brought many benefits to life, especially in the field of education, by facilitating access to information, increasing learning interactions, and expanding learning opportunities. In education, technology can be included in learning media. However, there are many challenges faced in applying technology in learning. One technology that can be applied in learning is Augmented Reality (AR). AR technology is able to present the virtual world as if it were real. The application of AR in learning has many challenges such as funding and students lack of digital literacy. So this research was carried out in the form of a bibliometric analysis of the use of AR in learning. This analysis was carried out using the publish or perish application and VOSviewer to search and analyze articles. Research articles starting from 2014-2024 state the use of AR in the last 10 years. The results of the bibliometric analysis state that the use of AR in learning is divided into 5 clusters, this research has started to emerge since 2022, and research that has not yet been widely carried out is the use of digital teaching materials with AR. Research related to digital teaching materials with AR could become a new trend in 2024.
KNOWLEDGE OF STROKE AMONG HYPERTENSIVE PATIENTS IN MOROCCO
Authors: Nezha Nacer , Asmaa Echafi , Chaima Gueddari , Ahmed Idbenjabbar
Published: August 2024

Background: Cerebrovascular accidents are increasingly becoming a growing source of disability and death. However, it is possible to prevent them by raising awareness of their risk factors and ensuring early management of patients. Aim: The study aims to determine the prevalence of stroke and study the knowledge of hypertensive patients regarding risk factors and warning signs at the health facilities in the province of Essaouira, Morocco. Materials and Methods: This is a cross-sectional quantitative analytical study of hypertensive patients in the province of Essaouira, Morocco. Results:455 participants took part in the study. 66.4% of patients were women, 50.5% were aged 60 or over, and 62.2% lived in urban areas. Most were married (64%) and had no formal education (58.2%). 7% of patients had a history of stroke diagnosed by a healthcare professional. 68% of participants identified numbness or weakness of the face, arm or leg as the main warning sign. 59.3% of participants had a low level of knowledge about stroke. Age, level of education, place of residence, social security coverage, history of stroke in the respondent, as well as in immediate family, relatives and neighbors, were significantly (p<0.05) related to the level of stroke knowledge. Conclusion: The low level of knowledge about stroke among hypertensive patients highlights the need for increased awareness, both among these patients and in the community. It is therefore crucial to implement local education programs to encourage preventive behaviors and provide information on how to deal with the warning signs of stroke.
GREFFE DES CELLULES SOUCHES MESENCHYMATEUSES CHEZ LES DIABETIQUES TYPE 1 EXPERIENCE DU SERVICE DENDOCRINOLOGIE ET DIABETOLOGIE CHU MARRAKECH
Authors:   Service dEndocrinologie, Diabetologie, Maladies Metaboliques & NutritionCHU Mohammed VI Marrakech, Maroc., Ezzahra Mennani Fatima , Ismail Zahra ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques & NutritionCHU Mohammed VI Marrakech, Maroc., Ijdda Sara ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques & NutritionCHU Mohammed VI Marrakech, Maroc., Rafi Sana ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques & NutritionCHU Mohammed VI Marrakech, Maroc., El Mghari Ghizlane ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques & NutritionCHU Mohammed VI Marrakech, Maroc., El Ansari Nawal ,   Service dEndocrinologie, Diabetologie, Maladies Metaboliques & NutritionCHU Mohammed VI Marrakech, Maroc.
Published: August 2024

Les cellules souches mesenchymateuses se caracterisent par leur potentiel de differenciation en multiples lignees, la secretion de diverses cytokines, ainsi que leurs effets immuno- modulateurs, mettent les cellules souches mesenchymateuses en premiere ligne en matiere de therapie cellulaire et de regeneration tissulaire et ouvrent de belles perspectives davenir pour toutes les disciplines medicales non seulement pour la diabetologie. Lobjectif de notre etude est de mettre le point sur lapport des cellules souches mesenchymateuses provenant du tissu adipeux ou de la moelle osseuse de nos patient, dans lamelioration de la prise en charge du diabete de type 1. Notre etude denombrait au total 5 patients repondants a nos criteres dinclusion avec un sexe ratio de 0 ,6. Lage moyen est de 21.2 ans.Les besoins en insuline ont diminue chez la majorite des patients apres la greffe des cellules souches mesenchymateuses. La dose quotidienne moyenne dinsuline basale a passe de 0,46 UI/Kg/j en pre greffe a 0.37 UI/Kg/j apres 18 mois de suivi post greffe, pour linsuline rapide les besoins ont diminue de 17,5 UI /j en pre greffe a 11.5 UI/j apres 18 mois de suivi post greffe. Le taux dHbA1c a baisse chez la totalite des patients.
EINSTEINS THEORY OF RELATIVITY AND ORGANIZATIONAL FLEXIBILITY IN DIGITAL TRANSFORMATIONS
Authors: Mehrotra Ravi
Published: August 2024

The paper will illustrate an analogy of Einsteins Theory of Relativity with the features of organizational flexibility against the backdrop of digital transformations. The relativity of space-time on the structures of organizations in their dynamics has informed the research. Explain how principles of relativity time dilations and space curvatures can be applied in organizational adaptability and responsiveness to give insight on how such flexibility may be achieved in the organisations, especially during digital disruptions. The findings suggest that much like how relativity reset peoples understanding of physics, the flexible approach toward organizational change can reset success in the digital age.
Psychoemotional and autonomic disorders in pre-, peri- and postmenopausal women
Authors: Shishkova V. N.
Published: August 2024

The topicality of issues of health maintenance and quality of life improvement in pre-, peri- and postmenopausal women is associated with the increasingly growing socio-public activity of women in today’s context. A number of studies have found a direct relationship between the onset of menopause and appearance of symptoms of autonomic dysfunction, shift of mood, various sleep disorders, decreased performance, including intellectual one, increased irritability and anxiety. The symptoms of autonomic dysfunction are the most difficult ones for a woman during this period. The most common symptoms of the period covering peri- and postmenopause are hot flashes, severe sweating, chills, heat palpitations in combination with increased anxiety. At the same time, hot flashes and other presentations of autonomic dysfunction do not always mean the onset of menopause and is not obstetrician-gynecologists’ responsibility alone. Therefore, complaints about hot flashes in pre-, peri- and postmenopausal women should not be the only course for the prescription of menopausal hormone therapy, but require a more detailed study of their cause. Previously it was shown that clinically significant components of the MPS symptom complex can be associated with other causes, both somatic and neuropsychiatric. Thus, the effects of psychosocial risk factors on perimenopausal women health include acute or chronic stress, chronic negative emotions, low social status, low or missing social support, general distress, loneliness, etc. These factors often cause the development of anxiety disorders, which are accompanied not only by psycho-emotional presentations, but also by autonomic symptoms. Therefore, the symptoms of autonomic dysfunction caused by anxiety disorders and menopausal syndrome largely overlap. This review presents the characteristics of vegetative and psycho-emotional disorders at each stage of female reproductive ageing. A tofisopam therapy option for vegetative and psychoemotional disorders in pre-, peri- and postmenopausal women is discussed.
Cervicobrachialgia and lumboischialgia: A single effective approach to solving the problem
Authors: Golovacheva V. A. , Golovacheva A. A. , Belyaeva S. D.
Published: August 2024

The presented clinical case describes a patient with chronic musculoskeletal cervicobrachialgia and lumbosciatica, which are some of the most common neurological disorders. The authors identified the factors contributing to the onset and chronification of musculoskeletal pain: pain catastrophization, anxiety, kinesiophobia, physical inactivity, spending too much time in front of the computer, long-term static postures, comorbid diseases – chronic insomnia, episodic tension-type headache with pericranial tenderness. No therapeutic effect, pain reduction and returning to previous daily activity were earlier observed, the pain chronification factors were not assessed or corrected, no awareness conversations about the causes of the disease and prognosis were held, the patient was only offered pharmacotherapy as treatments, no therapeutic gymnastics was recommended, and no recommendations for ergonomics and motor activities for daily life were provided to the patient. A complex approach to the treatment, including awareness conversations, kinesiotherapy, kinesiotaping, Difendum (diclofenac potassium) therapy course were offered to the patient at the Sechenov University Clinic of Nervous Diseases. Kinesiotherapy is a modern, efficient yet proven method for treating chronic musculoskeletal pain. It includes therapeutic gymnastics, an exercise program for posture correction, recommendations for ergonomics and lifestyle. Difendum (diclofenac potassium) has become a drug of choice within the pharmacotherapy course. It is a non-steroidal anti-inflammatory drug that is widely used in Russian neurological practice and has a proven efficacy and safety profile in the treatment of musculoskeletal pain. It should be noted that Difendum was prescribed to the patient from the first days of treatment at the same time as he started to take a kinesiotherapy training course. The patient experienced a rapid pain relief while taking pharmaceutical therapy, which played an important role in supporting adherence to recommendations for increasing physical activities, ergonomics and therapeutic gymnastics. The complex treatment provided a relatively quick and efficient relief to the patient. After a 5-day course of treatment, he reported a decrease in pain syndrome and an increase in functional activities. After 3 months, the pain completely regressed, sleep and emotional state returned to normal, and daily activities improved. A 6-month follow-up examination showed a persistent therapeutic effect.
Early use of cladribine tablets for relapsing-remitting multiple sclerosis: Expert opinion
Authors: Popova E. V. , Abroskina M. V. , Bakhtiyarova K. Z. , Vlasov Ya. V. , Davydovskaia M. V. , Evdoshenko E. P. , Korobko D. S. , Nilov A. I. , Sutormin M. V. , Trinitatskiy Yu. V. , Khabirov F. A. , Sheiko G. E. , Shumilina M. V.
Published: August 2024

In March 2020, oral cladribine was licensed in Russian Federation for the treatment of adult patients with highly active relapsing multiple sclerosis as defined by clinical or imaging features. Three years after the introduction into the Russian market, practical aspects in the use of cladribine tablets we evaluated, including data from real-world studies and the experience gained in the own routine clinical practice. Early initiation of cladribine therapy, use of cladribine in treatment naïve patients and patients with suboptimal response to previous disease-modifying therapy, use of cladribine as the treatment of choice in patients with suboptimal response to platform disease-modifying therapy and washout period while switching to cladribine from other disease-modifying therapy. During the discussion thirteen neurologists from federal and regional centers experienced in multiple sclerosis diagnosis and therapy were asked to answer several questions regarding the practical use of cladribine tables and come to consensus opinion. Consent was reached if at least 75% of the experts agreed on a particular statement. The experts agreed on the possibility to switch patients to cladribine from platform disease-modifying therapy in case of MRI activity or neutralizing antibodies in the absence of relapses activity to achieve better disease control, potential cladribine effects on progression independent of relapses, washout period reduction while switching from natalizumab to cladribine. Consensus opinion will help to manage practical questions regarding cladribine usage.
Erratum in the article “Results from the open-label, single-center, clinical study assessing the efficacy and safety of a group cognitive stimulation therapy in Russian-speaking patients with the moderate dementia stage of Alzheimer's disease”
Authors: Editorial Article
Published: August 2024

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O educador social e a promoção da educação em espaços não escolares: Uma revisão sistemática
Authors: Leitão Hamilton Vale , Soares Stela Lopes
Published: August 2024

O papel do educador social na promoção da educação em espaços não escolares é plural e fundamental para o desenvolvimento integral dos indivíduos e comunidades que atende. Com isso, o objetivo deste estudo é discutir o papel do educador social na promoção da educação em espaços não escolares. Por meio da revisão sistemática da literatura, foram analisados estudos que discutem a importância da educação em espaços não formais e informais, o papel do/a educador/a social na construção do conhecimento, a aproximação com a realidade dos educandos, as parcerias e articulações com o terceiro setor, bem como os desafios para essa modalidade de educação. Os resultados apontam que a atuação do educador social é fundamental para a promoção de uma educação de qualidade, inclusiva e transformadora. Por meio de práticas pedagógicas inovadoras, o educador social estimula a autonomia e o protagonismo dos educandos, promovendo aprendizagens significativas e contextualizadas. A proximidade com a realidade dos educandos possibilita uma educação mais relevante e alinhada às necessidades e interesses dos alunos. Além disso, a construção de parcerias e a articulação com o terceiro setor potencializam o trabalho do educador social, ampliando recursos e fortalecendo as ações educativas. No entanto, existem desafios a serem enfrentados, como a falta de recursos, as desigualdades sociais e os obstáculos burocráticos. Para superar esses desafios, é necessário o engajamento de políticas públicas efetivas, valorização dos profissionais da educação e fortalecimento das parcerias entre os diferentes atores envolvidos. Este estudo contribui para a valorização do educador social e ressalta a importância da educação em espaços não escolares como uma alternativa complementar à educação formal. Investir na formação e valorização desses profissionais, bem como na criação de políticas públicas que fomentem a educação em espaços não escolares, é essencial para promover uma sociedade mais justa, igualitária e educadora.
O Projeto “Construindo uma Escola Antirracista” e seus efeitos na formação e nas práticas curriculares de professoras de uma escola pública em Uberlândia, MG
Authors: Da Silva Júnior Astrogildo Fernandes , Machado Léa Aureliano de Sousa
Published: August 2024

O presente texto tem como analisar as formas como o projeto “Construindo uma escola antirracista” reverberou, na formação, e nas práticas curriculares das professoras que atuavam na Educação Infantil de uma escola pública localizada na cidade de Uberlândia, MG. O projeto foi desenvolvido no período de outubro de 2020 a abril de 2022. O foco do projeto foi a Educação Infantil por ser o momento em que os estudantes ingressam na escola. Como metodologia optou-se pela abordagem qualitativa e recorreu à História Oral Temática. Foram entrevistadas oito professoras que participaram de todas as etapas do Projeto.  Foi possível constatar que o referido projeto, no que tange à maior parte das protagonistas, promoveu reflexões sobre situações de racismo no ambiente escolar e assim ampliar seus saberes e remodelar suas práticas curriculares.
Los nombres por el lógos. Una “adecuación” platónica de los nombres
Authors: Fernández Mouján Raimundo
Published: August 2024

En el Crátilo, Platón aborda la cuestión de la orthótes onomáton, la “exactitud” o “adecuación” de los nombres con respecto a aquello que nombrarían. Dos posturas se ponen en juego sobre tal adecuación (el convencionalismo de Hermógenes y el naturalismo de Crátilo), las cuales son desmontadas por el Sócrates platónico. ¿Pero solo dos? ¿No hay acaso en el Crátilo aunque sea la indicación de una posible “adecuación” platónica? Este artículo muestra esa posible “adecuación”. Para cumplir tal objetivo, se investiga la diferencia entre el nombre (o nombre “natural”) y la palabra, la necesidad de anclar la denominación en las esencias, y se muestra sobre todo que es necesario pensar la cuestión del nombre en relación con la del lógos. Para eso, se articula una lectura del Crátilo con una revisión de algunos pasajes del Fedón y del Sofista.
Strategi Komunikasi KPU Kota Semarang Dalam Mengajak Gen Z Menggunakan Hak Pilih #temanpemilih
Authors: Fitri Alifa Nur , Rohmah Siti , Ayu Aulia Suminar
Published: August 2024

Penelitian ini membahas peran dan tantangan Komisi Pemilihan Umum (KPU) dalam menghadapi Pemilu 2024 di Indonesia, dengan fokus pada Generasi Z sebagai pemilih dominan. Generasi Z, yang berjumlah 74,94 juta jiwa atau 27,94% dari total penduduk, sangat terhubung dengan teknologi digital dan media sosial. Meskipun ini mempermudah akses informasi, mereka juga rentan terhadap hoaks yang dapat merusak kepercayaan publik terhadap proses pemilu. Tantangan utama KPU adalah mengatasi penyebaran hoaks di media sosial dan merancang strategi komunikasi yang efektif untuk meningkatkan partisipasi politik anak muda. Penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan studi kasus.Hasil penelitian ini menunjukkan bahwa, pentingnya literasi politik dan strategi komunikasi yang adaptif pada Pemilu 2014 dan 2019, yang masing-masing mencapai 85,9% dan 91,3%.  KPU Kota Semarang telah menunjukkan keberhasilan dalam menggunakan media sosial dan kampanye kreatif seperti #temanpemilih, yang meningkatkan partisipasi pemilih bahkan dalam situasi pandemi. Penelitian ini menyoroti perlunya KPU terus berinovasi dalam menghadapi perubahan perilaku digital Generasi Z, dengan tujuan utama meningkatkan partisipasi politik generasi muda di Indonesia.
University transformation in evaluations of project team participants
Authors: Semenov Maksim Yu.
Published: August 2024

The format of project activities is firmly rooted in the higher education system. This approach is used intensively in the implementation of strategic changes at the level of higher education institutions. This paper examines the transformation process in Russian universities from the perspective of project team members who are responsible for the result. The empirical basis for the analysis is a questionnaire survey (N = 79) of participants of transformation project teams from four Russian universities of different types (classical / technical). The types of transformation projects being implemented in Russian universities were identified. The results show that the main initiator of such projects is primarily the university itself or its individual units. The hierarchy of success factors of university transformation projects implementation in the understanding of their direct executors was determined, among which the most important are the competence of team members (71%), financial and resource support of the project (63%). The principles of project team formation are analyzed, which is mainly (37%) created based on the functional activity of the university employee outside the project. The most pronounced signs of success of a particular transformation project depending on its type are outlined. In the conclusion, we formulate the areas for further research on this topic.
Human capital and the social space of labor: on the VIII St. Petersburg International Labor Forum
Authors: Tarando Elena E. , Rubtcova Mariia V. , Lipatova Ludmila N. , Simtikov Zhomart K.
Published: August 2024

The article provides an overview of the work of the sociological section “Human Capital and the Social Space of Labor: Opportunities and Innovations”, which took place within the framework of the International conference “Human Capital: Education, Labor, Employment in Modern Society”, dedicated to the 300th anniversary of St. Petersburg State University, which was held under the auspices of the VIII St. Petersburg International Labor Forum.
Three reports were presented at the section. The first report concerned the consideration of analytics as one of the basic labor competencies. The second report presented the results of a sociological study of informally self-employed people regarding their attitude towards formalization. The third report was devoted to the analysis of the development of human capital of Chinese civil servants from the perspective of the modern head of state Xi Jinping.
Kant and modern law
Authors: Salenko Alexander V.
Published: August 2024

On April 22, 2024, the world celebrated the 300th anniversary of the birth of Immanuel Kant, an outstanding thinker who was not only a philosopher, but can rightfully be called a jurist. Kant’s ideas have become the foundation for modern law. Kant’s philosophy of law has a significant influence on the legal systems of states that consider themselves democratic, legal, and republican. Kant’s ideas have gained particular importance in the field of international law, constitutional law, and the theory of state and law. Kant’s categorical imperative, in essence, has become a key legal value that is enshrined in the vast majority of the constitutions of democratic states. Moreover, Kant’s concept of the dignity of the individual is the cornerstone of the modern doctrine of human and civil rights and freedoms. The philosopher’s ideas about the limits of human rights have also found legislative embodiment and practical application. Immanuel Kant developed the foundations of the legal concept of “limits of limits” of human rights and freedoms (German: Schranken-Schranken-Theorie). The Kant’s formula that the right of one person ends where the right of another begins has become widely accepted. According to Immanuel Kant’s ideas, all fundamental and other derivative human rights and freedoms have their limits and should not be used to harm or prejudice the rights of others. The author believes that the philosophical ideas of Immanuel Kant in the 21st century have not only not become obsolete but have gained even greater relevance and practical significance, which applies, among other things, to the Russian Federation, which is still continuing its slow and problem-ridden ascent to the rule of law.
Amplifying Radiotherapy by Evoking Mitochondrial Oxidative Stress using a High-performance Aggregation-induced Emission Sonosensitizer
Authors: Li Xing , Sun Yingshu , Wang Yilin , Zhou Ye , Bao Yixuan , Zhang Zhuomiao , Liu Shujing , Yang Huini , Zhang Ruoyao , Xia Peng , Ji Meiju , Hou Peng , Chen Chao
Published: August 2024

Introduction:

Developing effective methods to enhance tumor radiosensitivity is
crucial for improving the therapeutic efficacy of radiotherapy (RT). Due to its deep tissue
penetration, excellent safety profile, and precise controllability, sonosensitizer-based sonodynamic
therapy (SDT) has recently garnered significant attention as a promising combined approach
with RT.

Methods:

However, the limited reactive oxygen species (ROS) generation ability in the aggregated
state and the absence of specific organelle targeting in sonosensitizers hinder their
potential to augment RT. This study introduces a fundamental principle guiding the design of
high-performance sonosensitizers employed in the aggregated state. Building upon these principles,
we develop a mitochondria-targeted sonosensitizer molecule (TCSVP) with aggregation-
induced emission (AIE) characteristics by organic synthesis. Then, we demonstrate the
abilities of TCSVP to target mitochondria and produce ROS under ultrasound in H460 cancer
cells using confocal laser scanning microscopy (CLSM) and fluorescence microscopy.
Subsequently, we examine the effectiveness of enhancing tumor radiosensitivity by utilizing
TCSVP and ultrasound in both H460 cells and H460 and 4T1 tumor-bearing mice.

Results:

The results indicate that evoking non-lethal mitochondrial oxidative stress in tumors
by TCSVP under ultrasound stimulation can significantly improve tumor radiosensitivity (p
<0.05). Additionally, the in vivo safety profile of TCSVP is thoroughly confirmed by histopathological
analysis.

Conclusion:

This work proposes strategies for designing efficient sonosensitizers and underscores
that evoking non-lethal mitochondrial oxidative stress is an effective method to enhance
tumor radiosensitivity.
Myristic Acid Solid Lipid Nanoparticles Enhance the Oral Bioavailability and Therapeutic Efficacy of Rifaximin against MRSA Pneumonia
Authors: Zhang Yumin , Zhang Aoxue , Chen Dongmei , Xie Shuyu
Published: August 2024

Background:

Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is one of
the leading causes of death and an immense financial burden on healthcare systems. Rifaximin
(RFX) has good antibacterial activity against MRSA, but its clinical application is limited due to its
poor oral absorption. Solid lipid nanoparticles have good biocompatibility, high drug loading, sustained
release performance, and the inertia of lipids in gastric acid, which facilitates oral drug delivery.

Objective:

In order to improve the oral bioavailability of rifaximin and expand the clinical application
of RFX for MRSA pneumonia, this study developed RFX-loaded myristic acid solid lipid nanoparticles
(RFX-SLNs).

Methods:

This study first prepared RFX-SLNs through hot melt emulsification and ultrasonic methods
and selected the optimal formula of RFX-SLNs through single-factor screening. Afterward, the particle
size, zeta potential, and polydispersity index (PDI) of the RFX-SLNs were measured, the morphology
of RFX-SLNs was observed by transmission electron microscopy, and the encapsulation efficiency
(EE) and drug loading capacity (LC) of RFX-SLNs were detected by high-performance liquid chromatography.
Then, the sustained release ability and oral bioavailability of RFX-SLNs were studied through
in vitro release and pharmacokinetics. Finally, the therapeutic effect of RFX-SLNs on MRSA pneumonia
infection was studied by using a mouse MRSA pneumonia infection model.

Results:

The optimal formulation of RFX-SLNs was 1% RFX with water (3% PVA) and oil
(myristic acid) ratio of 1:19. RFX-SLNs were spherical in shape with a smooth surface and uniform
size. The EE and LC of three different batches of RFX-SLNs were 89.35±2.47%, 90.45±3.69%,
88.72±1.18%, and 9.50 ± 0.01%, 10.09±0.01%, and 9.68±0.00%, respectively. In vitro release
and pharmacokinetic studies showed that the myristic acid solid lipid nanoparticles showed excellent
sustained release as expected and increased the oral bioavailability of RFX by 2.18 times. This indicates
that RFX-SLNs can be used for the oral treatment of bacterial infections. Compared to RFX,
RFX-SLNs showed good therapeutic effects in a mouse MRSA pneumonia infection model

Conclusion:

This study indicates that the myristic acid solid lipid nanoparticles might be an effective
way to enhance the oral absorption and therapy effects of RFX and other insoluble drugs. This not only
opens up avenues for the clinical application of RFX but also provides a way for the development of
new dosage forms of water-soluble drugs and the expansion of their clinical application scope.
Strategies for Pain Management after Extraction of Primary Teeth: A Systematic Review of Randomized Clinical Trials
Authors: Rodrigues Janina , Palma Luiz Felipe , da Silva Gabriela Seabra , França Lucas Santiago , Alves Lívia Araújo , Raggio Daniela Prócida , Tedesco Tamara Kerber
Published: August 2024

Background:

In dental extractions, particularly when local anesthesia is used, it usually
offers analgesic relief for a few hours. However, pain can become a notable concern in the immediate
postoperative period due to the trauma experienced by both soft and hard oral tissues.

Objectives:

This systematic review aimed to evaluate the most effective strategies for managing
postoperative pain in primary tooth extractions.

Methods:

Two examiners conducted a search across five electronic databases: MEDLINE (via
PubMed), Embase, Scopus, Web of Science, CENTRAL, and OpenGray. Studies were included if
they met the following criteria after reviewing their titles and abstracts: they involved children and
evaluated pain management following primary tooth extraction. Subsequently, articles that described
extractions performed under any form of sedation, were not conducted under local anesthesia,
in an outpatient setting, and in children aged 0 to 12 years, or were not randomized controlled
trials, were excluded.

Results:

The search yielded 374 relevant articles, of which 9 were included. Among these, 5 utilized
preoperative medications as a pain management strategy, one evaluated low-level laser therapy
(LLLT) postoperatively, one assessed calendula drops postoperatively, and another explored
virtual reality during the procedure and arnica in solution both pre and postoperatively.

Conclusion:

Among all the strategies evaluated, the strategy involving analgesics administered 30
minutes before tooth extractions was supported by better-designed studies. However, there is a
high risk of bias.
Contemporary Jurisprudence and Legal Abortion in Asian Muslim Countries: The Politics of Global Abortion Rights
Authors: Tayebi Naeimeh , Radmehr Zohreh , Ghodrati Fatemeh
Published: August 2024

Background:

Religion plays an important role in a patient's decision to have an abortion,
as well as in a country's abortion policy. However, a holistic understanding of the position of Asian
Islamic countries has been less researched.

Objective:

Contemporary jurisprudence and legal abortion in Asian Muslim countries; The politics
of global abortion rights.

Method:

The article examined jurisprudence and legal issues of abortion in 12 Asian Muslim countries
between 1990 and 2021, searching in reliable databases using the keywords of “abortion, civil
law, criminal consequences.” The exclusion criteria were inadequate data in the study, editorial
studies, and case reports.

Results:

Abortion at the mother's request is legal in Turkey, Tajikistan, Kyrgyzstan, Turkmenistan
and the Republic of Azerbaijan. In Iran, Malaysia, Afghanistan, Brunei and Indonesia, abortion is
forbidden at any stage of gestation but before 4 months (Iran) and up to 22 weeks (Malaysia). In
Brunei and Indonesia, it is permitted if a mother’s life is in danger. Abortion is legal in Bangladesh
under the heading of "menstrual regulation," but a mother's request for abortion is illegal unless the
mother's life is in danger. Termination of pregnancy is a crime and punishable in Pakistan unless it
is done in good faith or to preserve the woman's life through "necessary treatment."

Conclusion:

The diversity of procedures in Asian Muslim countries depends on their legal system,
whether it is exclusively based on Sharia law (Iran), a combination of Sharia law along with civil
law (Saudi Arabia), or whether the legal system is not officially based on Sharia laws (Turkey).
effect of adding fermented garlic (Allium sativum) peel extract through drinking water on intestinal histology, meat chemistry, and digestive tract microbes of broilers
Authors: Prabayanti I. A. S. T. , Dewi I. G. A. M. K. , Nuriyasa I. M.
Published: August 2024

The study aimed to determine the effect of additional fermented garlic peel extract through drinking water on intestinal histology, meat chemical quality, and microbes of the digestive tract of broilers aged 4 weeks. The research was conducted at Sesetan Farm, Faculty of Animal Science, Udayana University, Jalan Raya Sesetan, Gang Markisa Number 5, Sesetan Village, South Denpasar District, Denpasar City, Bali. The design used was a completely randomized design with 4 treatments and 4 replicates, each replicate containing 5 broilers so the total number of broilers used was 80. The treatments given were broiler chickens given drinking water without garlic peel extract P0 (Control), broiler chickens treated with 1.5% garlic peel extract in drinking water (P1), broiler chickens treated with 3% garlic peel extract in drinking water (P2), broiler chickens treated with 4.5% garlic peel extract in drinking water (P3). The variables observed were villi height, kripta depth, ash content, water content, fat content, protein content, carbohydrate content, total plate count (TPC), lactic acid bacteria (BAL), escherichia coli, and Coliform.
FUEL PROPERTIES AND DIESEL ENGINE EXHAUST GAS TEMPERATURE OF BIODIESEL-CALOPHYLLUM INOPHYLLUM-ESSENTIAL OIL MIXTURE
Authors: Gamayel Adhes , Priyadi Muhammad Untung Zaenal
Published: August 2024

This research investigates the properties and performance of fuel blends comprising biodiesel, Calophyllum inophyllum oil (Nyamplung), and essential oils. Biodiesel, a renewable energy source, has gained significant attention due to its low sulfur content, high calorific value, and biodegradability. Experimental investigations involved blending biodiesel with Nyamplung oil and essential oils (clove oil, pine oil, and turpentine oil) in varying proportions. Fuel properties, including density, viscosity, and flash point, were analyzed to assess combustion characteristics. Additionally, engine performance parameters such as torque and exhaust gas temperature (EGT) were evaluated to understand combustion efficiency and engine health. The results revealed that the addition of Nyamplung oil and essential oils increased the density and viscosity of the fuel blends compared to pure biodiesel, impacting atomization and combustion processes. Despite higher viscosity potentially causing ignition delay, flash points decreased due to the presence of essential oils, enhancing safety during storage and handling. Torque measurements indicated variations in engine performance among fuel mixtures, with incomplete combustion observed in blends containing essential oils. EGT measurements further highlighted differences in combustion completeness, with lower temperatures observed in pure biodiesel due to improved atomization and complete combustion.
STUDY OF VOCATIONAL QUALITY ASSURANCE PERFORMANCE IN PREPARATION FOR SCHOOL SELF-EVALUATION IN THE COVID-19 PANDEMIC ERA
Authors: Arifin Zainal , Widodo Syukri Fathudin Achmad , Wiyono Giri , Sutikno Agus , Darmono Darmono
Published: August 2024

This research is based on the results of initial observations and field observations, such as: (1) the quality of SMK graduates is still low, especially with the current world problem, namely the COVID-19 pandemic. (2) there are still some educational quality standards that need to be improved and even improved their achievements. (3) many vocational high schools have implemented a school quality assurance system, but why is the quality of their graduates still low. The purpose of this study is to determine the assessment of school principals, teachers, school committees, and vocational students to photograph the efforts made by vocational quality assurance, especially in preparing the School Self Evaluation (SSE) as the main capital in the accreditation activities of the school concerned.The research method used is the descriptive quantitative research method. The research population is Vocational High School, while the sample is taking 4 Vocational High Schools that have implemented a Quality Assurance System, especially QMS ISO 9001:2008 or QMS ISO 9001:2015, such as several Vocational High Schools located in the Province of D.I. Yogyakarta and Central Java. Research data were collected based on the results of the distribution of questionnaires (instruments), interviews, observations, documentation studies, and Focus Group Discussions (FGD). The filler of the research instrument is the principals, teachers, school committees, and the concerned vocational students. The research data were analyzed descriptively quantitatively to see how far the level of achievement of the eight National Education Standards (NES) that had been set in the RPS.The results of this study are: (1) schools in implementing a school quality assurance system through their SSE have used four stages, consist of standard-setting, standard fulfillment, continuous evaluation, and quality improvement. (2) schools have taken correct and appropriate steps in achieving their vision and mission based on the formulated SPMI guidelines, (3) schools have implemented eight NESs starting from standards: graduates, content, process, educational assessment, educators and education personnel, educational facilities and infrastructure, education management, and financing standards properly. (4) each vocational high school has the same or different strategies and methods in achieving the school's vision and mission.
Comparison of the Burdens and Attitudes Between Standard and Web-Based Remote Programming for Deep Brain Stimulation in Parkinson Disease: Survey Study
Authors: Wan Xiaonan , Lin Zhengyu , Duan Chengcheng , Zeng Zhitong , Zhang Chencheng , Li Dianyou
Published: August 2024

Background

Remote programming enables physicians to adjust implantable pulse generators over the internet for patients with Parkinson disease who have undergone deep brain stimulation (DBS) surgery. Despite these technological advances, the demand for and attitudes toward remote programming compared with standard programming among patients with Parkinson disease are still not well understood.

Objective

This study aims to investigate the preferences and perceptions associated with these 2 programming methods among patients with Parkinson disease through a web-based survey.

Methods

A web-based survey was administered to 463 patients with Parkinson disease who have undergone DBS surgery. The survey aimed to assess the burdens associated with postoperative programming and to compare patients’ attitudes toward the 2 different programming methods.

Results

A total of 225 patients completed the survey, all of whom had undergone standard programming, while 132 patients had also experienced remote programming. Among those who received standard programming, 191 (85%) patients required the support of more than 1 caregiver, 129 (58%) patients experienced over 2 days of lost work time, 98 (42%) patients incurred expenses ranging from US $42 to US $146, and 14 (6%) patients spent over US $421. Of the 132 patients who had used remote programming, 81 (62%) patients indicated a preference for remote programming in the future. However, challenges with remote programming persisted, including difficulties in obtaining official prescriptions, a lack of medical insurance coverage, and limited medical resources.

Conclusions

Postoperative programming of DBS imposes significant burdens on patients and their caregivers during standard programming sessions—burdens that could be mitigated through remote programming. While patient satisfaction with remote programming is high, it is imperative for clinicians to develop personalized programming strategies tailored to the needs of different patients.
Correction: Vaccine Hesitancy in Taiwan: Temporal, Multilayer Network Study of Echo Chambers Shaped by Influential Users (Preprint)
Authors: Yin Jason Dean-Chen
Published: August 2024

UNSTRUCTURED
Application of Artificial Intelligence in Teaching English as a Foreign Language: Progress, Challenges, and Trends
Authors: Wu Lin , Li Keying , Yu Meiqi , Lin Yunxi
Published: August 2024

With the rapid development of artificial intelligence (AI) technology, its application in teaching English as a foreign language (EFL) is becoming increasingly widespread, profoundly affecting teaching models and learning experiences. This paper reviews AI application progress, challenges, and future trends in EFL instruction. It points out that AI technology supports effective EFL instruction through personalized teaching, automated assessment and feedback, active and interactive experiences, data-driven learning analytics, intelligent agents/virtual assistants, and humanoid robots. However, challenges such as technological limitations, gaps in AI acceptance and application capabilities, privacy protection and ethical issues, and unequal distribution of EFL instructional resources have also emerged. These challenges require active responses from educational administrative departments, schools, and EFL educators. In the future, the development of AI+EFL education will likely further promote innovation in EFL instruction models, achieve a more learner-centered teaching paradigm, exert a constructive influence, promote interdisciplinary integration and collaboration, and ensure the improvement of educational quality and equity.
Pesquisa documental em educação: contribuições para a formação continuada de professores
Authors: Salvatori Ana Paula , Henrique Gomes Allan , Fusca Machado Cordeiro Aliciene
Published: August 2024

O presente artigo tem por objetivo constituir um diálogo teórico sobre a pesquisa documental no âmbito da formação continuada de professores, à luz das contribuições da professora Marli André sobre pesquisas qualitativas no campo da educação. Para este fim, mapeamos os estudos da professora Marli André que fizeram o uso da análise de documentos, de modo a situar a concepção da autora sobre as fontes documentais na pesquisa em educação. Em conjunto, apresentamos um recorte de uma pesquisa-intervenção realizada com docentes da educação básica, que se estruturou como um percurso formativo. Os registros de áudio, vídeo, texto e imagem dos encontros do percurso formativo constituíram um acervo documental da pesquisa. Essa produção documental, em diálogo com as discussões da professore Marli André sobre a pesquisa qualitativa, permitiu pensar novos arranjos para a pesquisa documental no campo da educação, especialmente na formação continuada de professores.
Ensino remoto: uma nova distância para a educação superior?
Authors: Karwoski Acir Mario , Bernardo Julio Cesar Oliveira
Published: August 2024

O Ensino Remoto (ER), uma modalidade aproximada de educação a distância, tornou-se, na maior parte das instituições escolares, a única possibilidade para práticas de ensino e aprendizagem durante a pandemia. A pesquisa bibliográfica se depara com a questão problema: como sistemas de ensino puderam/podem se adaptar à emergencial adoção de uma nova estrutura de ensino remoto? O objetivo principal foi investigar disposições iniciais do ER em instituições de educação superior públicas, valendo-se dos objetivos específicos de levantar ações pedagógico-institucionais diante do ER e analisar contextos de aplicabilidade desse ensino. As reflexões surgiram a partir das discussões emergidas em uma disciplina de pós-graduação em Educação com temática voltada para tecnologias e formação de professores, em uma universidade pública. Utilizou-se, além de referências atinentes, pesquisa documental. Cinco plataformas de ER de universidades públicas foram analisadas a fim de possibilitar maior familiaridade com esse fenômeno de modo que as constatações e indagações contribuam para o aprimoramento de ideias ou para possibilitar o repensar de alguns conceitos pré-existentes. A abordagem foi qualitativa a partir da observação de alguns tópicos e a análise para o despertar de questionamentos ou compreensões em torno do ER em tempo de pandemia. Os resultados mostram conquistas e relevantes desafios, em especial no planejamento das plataformas, formação de professores e avaliação.
O Webinar como recurso na pós-graduação a distância: interdisciplinaridade e interação
Authors: Gambôa Chimenes Edna , Cristina Hobmeir Elaine , Teixeira Filho Clóvis
Published: August 2024

As TICs são importantes para a Educação a Distância no cenário atual. Este artigo apresenta um estudo de caso acerca da interação de estudantes em webinários desenvolvidos na pós-graduação na área de comunicação durante a pandemia. Respalda à proposta desta pesquisa referencial teórico a respeito dos elementos que a compõem, particularmente sobre as mudanças educacionais na pandemia. Alicerçado sobre tal base teórica se insere um estudo de caso consoante a perspectiva de Yin (2001). O mecanismo crítico englobou a pesquisa exploratória, por meio de cinco webinários registrados pelos alunos no ambiente virtual de aprendizagem. Conforme os princípios de Bardin (2011) para análise de conteúdo, partiu-se de uma pré-análise, seguida por exploração do material, tratamento dos resultados, inferência e interpretação. Como resultado, este artigo apresenta efetiva participação durante os eventos, com práticas interdisciplinares para a construção dos conhecimentos, pautadas por um ritual de interação e pela socialização.