bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling of Protein–Protein Interactions in Cytokinin Signal Transduction
Authors: Arkhipov Dmitry V. , Lomin Sergey N. , Myakushina Yulia A. , Savelieva Ekaterina M. , Osolodkin Dmitry I. , Romanov Georgy A.
Published: April 2019

The signaling of cytokinins (CKs), classical plant hormones, is based on the interaction of proteins that constitute the multistep phosphorelay system (MSP): catalytic receptors—sensor histidine kinases (HKs), phosphotransmitters (HPts), and transcription factors—response regulators (RRs). Any CK receptor was shown to interact in vivo with any of the studied HPts and vice versa. In addition, both of these proteins tend to form a homodimer or a heterodimeric complex with protein-paralog. Our study was aimed at explaining by molecular modeling the observed features of in planta protein–protein interactions, accompanying CK signaling. For this purpose, models of CK-signaling proteins’ structure from Arabidopsis and potato were built. The modeled interaction interfaces were formed by rather conserved areas of protein surfaces, complementary in hydrophobicity and electrostatic potential. Hot spots amino acids, determining specificity and strength of the interaction, were identified. Virtual phosphorylation of conserved Asp or His residues affected this complementation, increasing (Asp-P in HK) or decreasing (His-P in HPt) the affinity of interacting proteins. The HK–HPt and HPt–HPt interfaces overlapped, sharing some of the hot spots. MSP proteins from Arabidopsis and potato exhibited similar properties. The structural features of the modeled protein complexes were consistent with the experimental data.
Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors
Authors: Pallavicini Gianmarco , Berto Gaia E. , Di Cunto Ferdinando
Published: April 2019

Glioblastoma multiforme and medulloblastoma are the most frequent high-grade brain tumors in adults and children, respectively. Standard therapies for these cancers are mainly based on surgical resection, radiotherapy, and chemotherapy. However, intrinsic or acquired resistance to treatment occurs almost invariably in the first case, and side effects are unacceptable in the second. Therefore, the development of new, effective drugs is a very important unmet medical need. A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. Under this perspective, genes mutated in congenital microcephaly represent interesting candidates. Congenital microcephaly comprises a heterogeneous group of disorders in which brain volume is reduced, in the absence or presence of variable syndromic features. Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. Microcephaly genes encode for a few kinases, including CITK, PLK4, AKT3, DYRK1A, and TRIO. In this review, we summarize the evidence indicating that the inhibition of these molecules could exert beneficial effects on different aspects of brain cancer treatment.
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
Authors: Pavlou Sofia , Augustine Josy , Cunning Rónán , Harkin Kevin , Stitt Alan W. , Xu Heping , Chen Mei
Published: April 2019

Retinal vascular and neuronal degeneration are established pathological features of diabetic retinopathy. Data suggest that defects in the neuroglial network precede the clinically recognisable vascular lesions in the retina. Therefore, new treatments that target early-onset neurodegeneration would be expected to have great value in preventing the early stages of diabetic retinopathy. Here, we show that the nucleoside reverse transcriptase inhibitor lamivudine (3TC), a newly discovered P2rx7 inhibitor, can attenuate progression of both neuronal and vascular pathology in diabetic retinopathy. We found that the expression of P2rx7 was increased in the murine retina as early as one month following diabetes induction. Compared to non-diabetic controls, diabetic mice treated with 3TC were protected against the formation of acellular capillaries in the retina. This occurred concomitantly with a maintenance in neuroglial function, as shown by improved a- and b-wave amplitude, as well as oscillatory potentials. An improvement in the number of GABAergic amacrine cells and the synaptophysin-positive area was also observed in the inner retina of 3TC-treated diabetic mice. Our data suggest that 3TC has therapeutic potential since it can target both neuronal and vascular defects caused by diabetes.
Experiments with Snails Add to Our Knowledge about the Role of aPKC Subfamily Kinases in Learning
Authors: Chesnokova Ekaterina , Zuzina Alena , Bal Natalia , Vinarskaya Aliya , Roshchin Matvey , Artyuhov Alexander , Dashinimaev Erdem , Aseyev Nikolay , Balaban Pavel , Kolosov Peter
Published: April 2019

Protein kinase Mζ is considered important for memory formation and maintenance in different species, including invertebrates. PKMζ participates in multiple molecular pathways in neurons, regulating translation initiation rate, AMPA receptors turnover, synaptic scaffolding assembly, and other processes. Here, for the first time, we established the sequence of mRNA encoding PKMζ homolog in land snail Helix lucorum. We annotated important features of this mRNA: domains, putative capping sites, translation starts, and splicing sites. We discovered that this mRNA has at least two isoforms, and one of them lacks sequence encoding C1 domain. C1 deletion may be unique for snail because it has not been previously found in other species. We performed behavioral experiments with snails, measured expression levels of identified isoforms, and confirmed that their expression correlates with one type of learning.
DGA CapsNet: 1D Application of Capsule Networks to DGA Detection
Authors: Berman Daniel S.
Published: April 2019

Domain generation algorithms (DGAs) represent a class of malware used to generate large numbers of new domain names to achieve command-and-control (C2) communication between the malware program and its C2 server to avoid detection by cybersecurity measures. Deep learning has proven successful in serving as a mechanism to implement real-time DGA detection, specifically through the use of recurrent neural networks (RNNs) and convolutional neural networks (CNNs). This paper compares several state-of-the-art deep-learning implementations of DGA detection found in the literature with two novel models: a deeper CNN model and a one-dimensional (1D) Capsule Networks (CapsNet) model. The comparison shows that the 1D CapsNet model performs as well as the best-performing model from the literature.
Efficient Ensemble Classification for Multi-Label Data Streams with Concept Drift
Authors: Sun Yange , Shao Han , Wang Shasha
Published: April 2019

Most existing multi-label data streams classification methods focus on extending single-label streams classification approaches to multi-label cases, without considering the special characteristics of multi-label stream data, such as label dependency, concept drift, and recurrent concepts. Motivated by these challenges, we devise an efficient ensemble paradigm for multi-label data streams classification. The algorithm deploys a novel change detection based on Jensen–Shannon divergence to identify different kinds of concept drift in data streams. Moreover, our method tries to consider label dependency by pruning away infrequent label combinations to enhance classification performance. Empirical results on both synthetic and real-world datasets have demonstrated its effectiveness.
Effects of β-Adrenergic Antagonists on Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer
Authors: Chaudhary Kunal R. , Yan Sherry X. , Heilbroner Samuel P. , Sonett Joshua R. , Stoopler Mark B. , Shu Catherine , Halmos Balazs , Wang Tony J.C. , Hei Tom K. , Cheng Simon K.
Published: April 2019

Introduction: Locally advanced non-small cell lung cancer (NSCLC) is highly resistant to chemoradiotherapy, and many cancer patients experience chronic stress. Studies that suggest stimulation of β-adrenergic receptors (β-AR) promotes tumor invasion and therapy resistance. We investigated whether β-AR inhibition with beta-blockers acts as a chemotherapy and radiation sensitizer in vitro and in patients treated with chemoradiation for locally advanced NSCLC. Methods: We investigated the effects of the non-selective beta-blocker propranolol on two human lung adenocarcinoma cell lines (PC9, A549) treated with radiation or cisplatin. We retrospectively evaluated 77 patients with Stage IIIA NSCLC who received induction chemoradiation followed by surgery. Pathological and imaging response, metastatic rate, and survival were analyzed using SPSS v22.0 and PrismGraphpad6. Results: Propranolol combined with radiation or cisplatin decreased clonogenic survival of PC9 and A549 cells in vitro (p < 0.05). Furthermore, propranolol decreased expression of phospho-protein kinase A (p-PKA), a β-adrenergic pathway downstream activation target, in both cell lines compared to irradiation or cisplatin alone (p < 0.05). In patients treated for Stage IIIA NSCLC, 16 took beta-blockers, and 61 did not. Beta-blockade is associated with a trend to improved overall survival (OS) at 1 year (81.3% vs 57.4%, p = 0.08) and distant metastasis-free survival (DMFS) (2.6 years vs. 1.3 years, p = 0.16). Although beta-blocker use was associated with decreased distant metastases (risk ratio (RR) 0.19; p = 0.03), it did not affect primary tumor pathological response (p = 0.40) or imaging response (p = 0.36). Conclusions: β-AR blockade enhanced radiation and cisplatin sensitivity of human lung cancer cells in vitro. Use of beta-blockers is associated with decreased distant metastases and potentially improved OS and DMFS. Additional studies are warranted to evaluate the role of beta-blockers as a chemoradiation sensitizer in locally advanced NSCLC.
The IGF1 Receptor Is Involved in Follicle-Stimulating Hormone Signaling in Porcine Neonatal Sertoli Cells
Authors: Cannarella Rossella , Arato Iva , Condorelli Rosita A. , Luca Giovanni , Barbagallo Federica , Alamo Angela , Bellucci Catia , Lilli Cinzia , La Vignera Sandro , Calafiore Riccardo , Mancuso Francesca , Calogero Aldo E.
Published: April 2019

Experimental evidence has shown that the IGF1 receptor (IGF1R) is involved in testicular development during embryogenesis. More recently, data gathered from mice granulosa cells and zebrafish spermatogonia suggest that IGF1R has a role in Follicle-stimulating hormone (FSH) signaling. No evidence has been reported on this matter in Sertoli cells (SCs) so far. The aim of the study was to evaluate the role, if any, of the IGF1R in FSH signaling in SCs. The effects of FSH exposure on myosin-phosphatase 1 (MYPT1), ERK 1/2, AKT308, AKT473, c-Jun N-terminal kinase (JNK) phosphorylation and on anti-Müllerian hormone (AMH), inhibin B and FSH receptor (FSHR) mRNA levels were assessed with and without the IGF1R inhibitor NVP-AEW541 in purified and functional porcine neonatal SCs. Pre-treatment with NVP-AEW541 inhibited the FSH-induced MYPT1 and ERK 1/2 phosphorylation, decreased the FSH-dependent Protein kinase B (AKT)308 phosphorylation, but did not affect the FSH-induced AKT473 and JNK phosphorylation rate. It also interfered with the FSH-induced AMH and FSHR down-regulation. No influence was observed on the FSH-stimulated Inhibin B gene expression. Conclusion. These findings support the role of theIGF1R in FSH signaling in porcine SCs. The possible influence of IGF1 stimulation on the FSH-mediated effects on SCs should be further explored.
Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis
Authors: Smutny Tomas , Barvik Ivan , Veleta Tomas , Pavek Petr , Soukup Tomas
Published: April 2019

Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are closely related chronic inflammatory diseases. Glucocorticoids (GCs) are first-choice drugs for PMR and GCA, although some patients show poor responsiveness to the initial GC regimen or experience flares after GC tapering. To date, no valid biomarkers have been found to predict which patients are at most risk for developing GC resistance. In this review, we summarize PMR- and GCA-related gene polymorphisms and we associate these gene variants with GC resistance and therapeutic outcomes. A limited number of GC resistance associated-polymorphisms have been published so far, mostly related to HLA-DRB1*04 allele. Other genes such ICAM-1, TLR4 and 9, VEGF, and INFG may play a role, although discrepancies are often found among different populations. We conclude that more studies are required to identify reliable biomarkers of GC resistance. Such biomarkers could help distinguish non-responders from responders to GC treatment, with concomitant consequences for therapeutic strategy.
The Effects of Intraoperative Inspired Oxygen Fraction on Postoperative Pulmonary Parameters in Patients with General Anesthesia: A Systemic Review and Meta-Analysis
Authors: Koo Chang-Hoon , Park Eun Young , Lee Sun Young , Ryu Jung-Hee
Published: April 2019

High intraoperative inspired oxygen concentration is applied to prevent desaturation during induction and recovery of anesthesia. However, high oxygen concentration may lead to postoperative pulmonary complications. The purpose of this study is to compare the postoperative pulmonary parameters according to intraoperative inspired oxygen fraction in patients undergoing general anesthesia. We identified all randomized controlled trials investigating postoperative differences in arterial gas exchange according to intraoperative fraction of inspired oxygen (FiO2). A total of 10 randomized controlled trials were included, and 787 patients were analyzed. Postoperative PaO2 was lower in the high FiO2 group compared with the low FiO2 group (mean difference (MD) −4.97 mmHg, 95% CI −8.21 to −1.72, p = 0.003). Postoperative alveolar-arterial oxygen gradient (AaDO2) was higher (MD 3.42 mmHg, 95% CI 0.95 to 5.89, p = 0.007) and the extent of atelectasis was more severe (MD 2.04%, 95% CI 0.14 to 3.94, p = 0.04) in high intraoperative FiO2 group compared with low FiO2 group. However, postoperative SpO2 was comparable between the two groups. The results of this meta-analysis suggest that high inspired oxygen fraction during anesthesia may impair postoperative pulmonary parameters. Cautious approach in intraoperative inspired oxygen fraction is required for patients susceptible to postoperative pulmonary complications.
Pulmonary Vessel Obstruction Does Not Correlate with Severity of Pulmonary Embolism
Authors: Lerche Marianne , Bailis Nikolaos , Akritidou Mideia , Meyer Hans Jonas , Surov Alexey
Published: April 2019

The aim of the present study was to analyze possible relationships between pulmonary vessel obstruction and clinically relevant parameters and scores in patients with pulmonary embolism (PE). Overall, 246 patients (48.8% women and 51.2% men) with a mean age of 64.0 ± 17.1 years were involved in the retrospective study. The following clinical scores were calculated in the patients: Wells score, Geneva score, and pulmonary embolism severity index (PESI) score. Levels of D-dimer (µg/mL), lactate, pH, troponin, and N-terminal natriuretic peptide (BNP, pg/mL) were acquired. Thrombotic obstruction of the pulmonary arteries was quantified according to Mastora score. The data collected were evaluated by means of descriptive statistics. Spearman’s correlation coefficient was used to analyze associations between the investigated parameters. P values < 0.05 were taken to indicate statistical significance. Mastora score correlated weakly with lactate level and tended to correlate with D-dimer and BNP levels. No other clinical or serological parameters correlated significantly with clot burden. Thrombotic obstruction of pulmonary vessels did not correlate with clinical severity of PE.
Cognitive Reserve Assessment Scale in Health (CRASH): Its Validity and Reliability
Authors: Amoretti Silvia , Cabrera Bibiana , Torrent Carla , Bonnín Caterina del Mar , Mezquida Gisela , Garriga Marina , Jiménez Esther , Martínez-Arán Anabel , Solé Brisa , Reinares Maria , Varo Cristina , Penadés Rafael , Grande Iria , Salagre Estela , Parellada Eduard , Bioque Miquel , Garcia-Rizo Clemente , Meseguer Ana , Anmella Gerard , Rosa Adriane R , Contreras Fernando , Safont Gemma , Vieta Eduard , Bernardo Miquel
Published: April 2019

(1) Background: The cognitive reserve (CR) concept has not been precisely defined in severe mental disorders and has been estimated using heterogeneous methods. This study aims to investigate and develop the psychometric properties of the Cognitive Reserve Assessment Scale in Health (CRASH), an instrument designed to measure CR in people with severe mental illness; (2) Methods: 100 patients with severe mental illness (non-affective psychoses and affective disorders) and 66 healthy controls were included. The internal consistency and convergent validity of CRASH were assessed. Spearman’s correlations coefficients were also performed to examine the relationship between CRASH and neuropsychological tests, psychosocial functioning, and clinical course; (3) Results: The internal consistency was high (Cronbach’s alpha coefficient = 0.903). The CRASH global score had a large positive correlation with the Cognitive reserve questionnaire total score (r = 0.838, p < 0.001), demonstrating good convergent validity. The correlation coefficients between the CRASH total scores and clinical, functional, and neuropsychological performance were different between groups. In order to provide clinical interpretation, severity classification based on diagnosis (non-affective psychotic disorders, affective disorders, and healthy controls) have been created; (4) Conclusions: CRASH is the first CR measure developed specifically for patients with severe mental illness, facilitating reliable and valid measurement of this construct. The scale may aid in the stratification of patients and the implementation of personalized interventions.
Fast Tac Metabolizers at Risk—It is Time for a C/D Ratio Calculation
Authors: Schütte-Nütgen Katharina , Thölking Gerold , Steinke Julia , Pavenstädt Hermann , Schmidt René , Suwelack Barbara , Reuter Stefan
Published: April 2019

Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate is highly variable. A fast Tac metabolism rate, defined by the Tac blood trough concentration (C) divided by the daily dose (D), is associated with inferior renal function after RTx. Therefore, we hypothesize that the Tac metabolism rate impacts patient and graft survival after RTx. We analyzed all patients who received a RTx between January 2007 and December 2012 and were initially treated with an immunosuppressive regimen containing Tac (Prograf®), mycophenolate mofetil, prednisolone and induction therapy. Patients with a Tac C/D ratio <1.05 ng/mL × 1/mg at three months after RTx were characterized as fast metabolizers and those with a C/D ratio ≥1.05 ng/mL × 1/mg as slow metabolizers. Five-year patient and overall graft survival were noticeably reduced in fast metabolizers. Further, fast metabolizers showed a faster decline of eGFR (estimated glomerular filtration rate) within five years after RTx and a higher rejection rate compared to slow metabolizers. Calculation of the Tac C/D ratio three months after RTx may assist physicians in their daily clinical routine to identify Tac-treated patients at risk for the development of inferior graft function, acute rejections, or even higher mortality.
New Generation Cardiac Contractility Modulation Device—Filling the Gap in Heart Failure Treatment
Authors: Tint Diana , Florea Roxana , Micu Sorin
Published: April 2019

(1) Background: Heart failure (HF) is a major cause of morbidity and mortality throughout the world. Despite substantial progress in its prevention and treatment, mortality rates remain high. Device therapy for HF mainly includes cardiac resynchronization therapy (CRT) and the use of an implantable cardioverter-defibrillator (ICD). Recently, however, a new device therapy—cardiac contractility modulation (CCM)—became available. (2) Aim: The purpose of this study is to present a first case-series of patients with different clinical patterns of HF with a reduced ejection fraction (HFrEF), supported with the newest generation of CCM devices. (3) Methods and results: Five patients with a left ventricular ejection fraction (LVEF) ≤ 35% and a New York Heart Association (NYHA) class ≥ III were supported with CCM OPTIMIZER® SMART IPGCCMX10 at our clinic. The patients had a median age of 67 ± 8.03 years (47–80) and were all males—four with ischemic etiology dilated cardiomyopathy. In two cases, CCM was added on top of CRT (non-responders), and, in one patient, CCM was delivered during persistent atrial fibrillation (AF). After 6 months of follow-up, the LVEF increased from 25.4 ± 6.8% to 27 ± 9%, and the six-minute walk distance increased from 310 ± 65.1 m to 466 ± 23.6 m. One patient died 47 days after device implantation. (4) Conclusion: CCM therapy provided with the new model OPTIMIZER® SMART IPG CCMX10 is safe, feasible, and applicable to a wide range of patients with HF.
Prognostic Value of Systemic Inflammatory Indices, NLR, PLR, and MPV, for Predicting 1-Year Survival of Patients Undergoing Cytoreductive Surgery with HIPEC
Authors: Kim Na Young , Chun Duk-Hee , Kim So Yeon , Kim Nam Kyu , Baik Seung Hyuk , Hong Jung Hwa , Kim Kyung Sub , Shin Cheung-soo
Published: April 2019

The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) have been reported to be associated with the prognosis of various types of tumors. This study evaluated the prognostic value and clinical use of inflammatory markers for predicting 1-year survival in patients undergoing cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). This retrospective study included 160 patients who underwent CRS with HIPEC between July 2014 and April 2017. Data on NLR, PLR, and MPV were collected preoperatively and on postoperative days (POD) 1, 2, 3, 4, and 5. In a multivariate analysis using a cox proportional hazard regression model, higher values of preoperative NLR and MPV, PLR, and MPV on POD 2, 3, and 5 were associated with reduced 1-year survival after CRS with HIPEC. Patients with increased MPV showed lower rates of 1-year survival following CRS with HIPEC. In addition, elevated preoperative NLR and postoperative PLR were correlated with poor survival. These markers are able to stratify patients by risk profile, which may ultimately improve perioperative management and be helpful in improving outcomes following CRS with HIPEC.
Framework of an IoT-based Industrial Data Management for Smart Manufacturing
Authors: Saqlain Muhammad , Piao Minghao , Shim Youngbok , Lee Jong Yun
Published: April 2019

The Internet of Things (IoT) is the global network of interrelated physical devices such as sensors, actuators, smart applications, objects, computing devices, mechanical machines, and people that are becoming an essential part of the internet. In an industrial environment, these devices are the source of data which provide abundant information in manufacturing processes. Nevertheless, the massive, heterogeneous, and time-sensitive nature of the data brings substantial challenges to the real-time collection, processing, and decision making. Therefore, this paper presents a framework of an IoT-based Industrial Data Management System (IDMS) which can manage the huge industrial data, support online monitoring, and control smart manufacturing. The framework contains five basic layers such as physical, network, middleware, database, and application layers to provide a service-oriented architecture for the end users. Experimental results from a smart factory case study demonstrate that the framework can manage the regular data and urgent events generated from various factory devices in the distributed industrial environment through state-of-the-art communication protocols. The collected data is converted into useful information which improves productivity and the prognosis of production lines.
Long-Term Monitoring of Protected Cultural Heritage Environments in Norway: Development of Methods and First-Time Application
Authors: Eiter Sebastian , Fjellstad Wendy , Puschmann Oskar , Krøgli Svein Olav
Published: April 2019

Norway has a political goal to minimize the loss of cultural heritage due to removal, destruction or decay. On behalf of the national Directorate for Cultural Heritage, we have developed methods to monitor Cultural Heritage Environments. The complementary set of methods includes (1) landscape mapping through interpretation of aerial photographs, including field control of the map data, (2) qualitative and quantitative initial and repeat landscape photography, (3) field recording of cultural heritage objects including preparatory analysis of public statistical data, and (4) recording of stakeholder attitudes, perceptions and opinions. We applied these methods for the first time to the historical clustered farm settlement of Havrå in Hordaland County, West Norway. The methods are documented in a handbook and can be applied as a toolbox, where different monitoring methods or frequency of repeat recording may be selected, dependent on local situations, e.g., on the landscape character of the area in focus.
Temperature Stable Cold Sintered (Bi0.95Li0.05)(V0.9Mo0.1)O4-Na2Mo2O7 Microwave Dielectric Composites
Authors: Wang Dawei , Zhang Shiyu , Zhou Di , Song Kaixin , Feteira Antonio , Vardaxoglou Yiannis , Whittow Will , Cadman Darren , Reaney Ian M.
Published: April 2019

Dense (Bi0.95Li0.05)(V0.9Mo0.1)O4-Na2Mo2O7 (100−x) wt.% (Bi0.95Li0.05)(V0.9Mo0.1)O4 (BLVMO)-x wt.% Na2Mo2O7 (NMO) composite ceramics were successfully fabricated through cold sintering at 150 °C under at 200 MPa for 30 min. X-ray diffraction, back-scattered scanning electron microscopy, and Raman spectroscopy not only corroborated the coexistence of BLVMO and NMO phases in all samples, but also the absence of parasitic phases and interdiffusion. With increasing NMO concentration, the relative pemittivity (εr) and the Temperature Coefficient of resonant Frequency (TCF) decreased, whereas the Microwave Quality Factor (Qf) increased. Near-zero TCF was measured for BLVMO-20wt.%NMO composites which exhibited εr ~ 40 and Qf ~ 4000 GHz. Finally, a dielectric Graded Radial INdex (GRIN) lens was simulated using the range of εr in the BLVMO-NMO system, which predicted a 70% aperture efficiency at 26 GHz, ideal for 5G applications.
Comparing Properties of Concrete Containing Electric Arc Furnace Slag and Granulated Blast Furnace Slag
Authors: Lee Jin-Young , Choi Jin-Seok , Yuan Tian-Feng , Yoon Young-Soo , Mitchell Denis
Published: April 2019

For sustainable development in the construction industry, blast furnace slag has been used as a substitute for cement in concrete. In contrast, steel-making slag, the second largest by-product in the steel industry, is mostly used as a filler material in embankment construction. This is because steel-making slag has relatively low hydraulicity and a problem with volumetric expansion. However, as the quenching process of slag has improved recently and the steel making process is specifically separated, the properties of steel-making slag has also improved. In this context, there is a need to find a method for recycling steel-making slag as a more highly valued material, such as its potential use as an admixture in concrete. Therefore, in order to confirm the possibility of using electric arc furnace (EAF) oxidizing slag as a binder, a comparative assessment of the mechanical properties of concrete containing electric arc furnace oxidizing slag, steel-making slag, and granulated blast furnace (GBF) slag was performed. The initial and final setting, shrinkage, compressive and split-cylinder tensile strength of the slag concretes were measured. It was found that replacing cement with EAF oxidizing slag delayed the hydration reaction at early ages, with no significant problems in setting time, shrinkage or strength development found.
Removal of Chromates and Sulphates by Mg/Fe LDH and Heterostructured LDH/Halloysite Materials: Efficiency, Selectivity, and Stability of Adsorbents in Single- and Multi-Element Systems
Authors: Matusik Jakub , Rybka Karolina
Published: April 2019

Industrial wastewaters often contain mobile and toxic anions that cannot be removed by precipitation techniques and most known adsorbents. Layered double hydroxides (LDH) are excellent scavengers of anions; however, their use in real applications is of minor importance owing to their swelling behavior and high cost of production. The performed research shows the possibility of obtaining Mg/Fe LDH using natural magnesite. Moreover, heterostructured LDH/halloysite materials were synthesized. The adsorption efficiency of these materials was very high in both single- and multi-element systems, confirming the LDH selectivity. This was with the exception of wastewaters containing a high concentration of chlorides, which clearly hampered the removal of Cr(VI) and S(VI). The measurements indicated that LDH dissolution took place to a small extent (<10 wt%). The LDH/halloysite materials showed lower efficiency than the raw LDH; however, the clay presence has several benefits in terms of future applications: (i) it significantly reduces the pH, especially in contrast to the calcined LDH, which enables the reuse or safe disposal of purified water; (ii) it reduces swelling of the composite, which opens the possibility for applications in column adsorption; (iii) it induces dual adsorption properties through additional cation adsorption; and (iv) it substantially lowers the price of the adsorbent.
DFT Analysis of NO Adsorption on the Undoped and Ce-Doped LaCoO3 (011) Surface
Authors: Li Xiaochen , Gao Hongwei
Published: April 2019

Using the density functional theory (DFT) method, we investigated the adsorption of NO on the undoped and Ce-doped LaCoO3 (011) surface. According to our calculations, the best adsorption site is not changed after Ce doping. When the NO molecule is adsorbed on the perfect LaO-terminated LaCoO3 (011) surface, the most stable adsorption site is hollow-top, which corresponds to the hollow-NO configuration in our study. After the substitution of La with Ce, the adsorption energy of hollow-NO configuration is increased. For the perfect CoO2-terminated LaCoO3 (011) surface, it is found that Co-NO configuration is the preferential adsorption structure. Its adsorption energy can also be enhanced after Ce doping. When NO molecule is adsorbed on the undoped and Ce-doped LaO-terminated LaCoO3 (011) surface with hollow-NO configuration, it serves as the acceptor and electrons transfer from the surface to it in the adsorption process. On the contrary, for the Co-NO configuration of undoped and Ce-doped CoO2-terminated LaCoO3 (011) surface, NO molecule becomes the donor and loses electrons to the surface.
Effect of Multi-Directional Forging on the Microstructure and Mechanical Properties of β-Solidifying TiAl Alloy
Authors: Cui Ning , Wu Qianqian , Bi Kexiao , Wang Jin , Xu Tiewei , Kong Fantao
Published: April 2019

This study systematically investigated the influence of multi-directional forging (MDF) on the microstructural evolution, hot deformation behavior, and tensile properties of a β-solidifying TiAl alloy. The initial lamellar microstructure of an as-cast alloy was remarkably refined and homogenized by three-step MDF. High temperatures and multi-pass deformations were conducive to the decomposition of lamellae. A crack-free billet was obtained through three-step MDF, with a deformation temperature of 1250 °C and a forging speed of 0.1 mm/s, indicating that MDF can be applied to β-solidifying TiAl alloys by the proper control of the alloy composition and process parameters. Microstructural observation showed that the billet mainly consists of fine and equiaxed γ grains and a small amount of β phase. The tensile properties of the multi-directional forged alloy were also significantly improved, due to microstructure refinement. The ultimate tensile strength (UTS) and elongation (δ) at room temperature were 689.4 MPa, and 0.83%, respectively. The alloy exhibits excellent ductility at 700 °C. When the temperature was increased to 700 °C, the UTS decreased to 556 MPa and δ increased to 5.98%, indicating that the alloy exhibits excellent ductility at 700 °C. As the temperature further increased to 750 °C, δ dramatically increased to 46.65%, indicating that the ductile-brittle transition temperature of the alloy is between 700 °C and 750 °C.
The Intergranular Corrosion Susceptibility of Metastable Austenitic Cr–Mn–Ni–N–Cu High-Strength Stainless Steel under Various Heat Treatments
Authors: Liu Guangming , Liu Yuanyuan , Cheng Yawen , Li Jin , Jiang Yiming
Published: April 2019

The intergranular corrosion (IGC) behavior of a new metastable austenitic Cr–Mn–Ni–N–Cu high-strength stainless steel under various heat treatments was studied. The samples were solution treated at 1050 °C for 30 min and then aged at 600 to 900 °C for 10 to 300 min, respectively. The IGC susceptibility of aged samples was investigated using a double-loop electrochemical potentiokinetic reactivation (DL-EPR) test in a solution of 0.1 M H2SO4 and 0.002 M KSCN and the 10% oxalic acid etch. The surface morphologies of samples were characterized using optical microscopy and the scanning electron microscopy after electrochemical tests. Two time-temperature-sensitization diagrams were plotted based on the DL-EPR test and oxalic acid etching. No IGC and precipitate were observed for samples aged at 600 °C and 900 °C. For samples aged at 650 °C to 750 °C, the IGC susceptibility and the amount of precipitate both increased with the extended aging time. For samples aged at 800 °C and 850 °C, the amount of precipitate increased as the aging time was prolonged. However, only the sample aged at 800 °C for 60 min showed slight intergranular corrosion in the DL-EPR test. The IGC of the Cr–Mn–Ni–N–Cu austenitic stainless steel originated from the precipitation of Cr23C6 and Cr2N at the grain boundaries. The chromium-depleted zones near grain boundaries stood as the corrosion nucleation sites, but the dissolution of the weak area followed a consistent crystallographic orientation along each grain boundary.
Influencing Factors of Void closure in Skew-Rolled Steel Balls Based on the Floating-Pressure Method
Authors: Shu Chang , Wang Jitai , Shu Xuedao , Tian Duanyang
Published: April 2019

Due to the instable conditions caused by the wear of rollers, macro voids inevitably occur in skew rolling steel balls. Macro voids in rolled balls greatly weakens the mechanical properties, resulting in the scrapping of about 23% of all skew rolling balls. This paper adopts the floating-pressure method (FPM) to eliminate macro voids in rolled steel balls, and mainly focuses on the investigation of the influencing factor void closure in skew-rolled balls. The research contents are listed as follows: Firstly, the mechanical model of FPM eliminating void in rolled steel balls is established, and the theoretical relationship between influencing factors of void closure is obtained. Then, the metal flow behaviors, the stress distribution and the effect of process parameters on void closure are revealed by numerical analysis. Subsequently, based on the uniform design method, the prediction equation of the required temperature and air pressure for compacting various inferior rolled balls with different diameter by FPM is deduced. Finally, the FPM experiment is carried out to verify the results of numerical analysis. The research results provide theoretical guidance for eliminating macro voids in skew-rolled steel balls.
Wirelength of Enhanced Hypercube into Windmill and Necklace Graphs
Authors: Liu Jia-Bao , Arockiaraj Micheal , Delaila John Nancy
Published: April 2019

An embedding of an interconnection network into another is one of the main issues in parallel processing and computing systems. Congestion, dilation, expansion and wirelength are some of the parameters used to analyze the efficiency of an embedding in which resolving the wirelength problem reduces time and cost in the embedded design. Due to the potential topological properties of enhanced hypercube, it has become constructive in recent years, and a lot of research work has been carried out on it. In this paper, we use the edge isoperimetric problem to produce the exact wirelengths of embedding enhanced hypercube into windmill and necklace graphs.
Introduction to the Special Issue “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”
Authors: Sakagami Hiroshi
Published: April 2019

This editorial is a brief introduction to the Special Issue of “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”. From the natural resources and chemical modifications of the backbone structures of natural products, various attractive substances with new biological functions were excavated. Best fit combination of these materials may contribute in the treatment of oral diseases.
Detection and Estimation of Retained Austenite in a High Strength Si-Bearing Bainite-Martensite-Retained Austenite Micro-Composite Steel after Quenching and Bainitic Holding (Q&B)
Authors: Pashangeh Shima , Karimi Zarchi Hamid Reza , Ghasemi Banadkouki Seyyed Sadegh , Somani Mahesh C.
Published: April 2019

To develop an advanced high strength steel with reasonable ductility based on low alloying concept as well as micro-composite microstructure essentially consisting of bainite, martensite and retained austenite, a Si-bearing, low alloy medium carbon sheet steel (DIN1.5025 grade) was subjected to typical quenching and bainitic holding (Q&B) type isothermal treatment in the bainitic region close to martensite start temperature (Ms) for different durations in the range 5s to 1h. While the low temperature bainite has the potential to provide the required high strength, a small fraction of finely divided austenite stabilized between the bainitic laths is expected to provide the desired elongation and improved work hardening. Various materials characterization techniques including conventional light metallography, field emission scanning electron microscopy FE-SEM, electron backscatter diffraction (EBSD), differential thermal analysis, X-ray diffraction (XRD) and vibrating sample magnetometry (VSM), were used to detect and estimate the volume fraction, size and morphology and distribution of retained austenite in the micro-composite samples. The results showed that the color light metallography technique using LePera’s etching reagent could clearly reveal the retained austenite in the microstructures of the samples isothermally held for shorter than 30s, beyond which an unambiguous distinction between the retained austenite and martensite was imprecise. On the contrary, the electron microscopy using a FE-SEM was not capable of identifying clearly the retained austenite from bainite and martensite. However, the EBSD images could successfully distinguish between bainite, martensite and retained austenite microphases with good contrast. Although the volume fractions of retained austenite measured by EBSD are in accord with those obtained by XRD and color light metallography, the XRD measurements showed somewhat higher fractions owing to its ability to acquisition and analyze the diffracted X-rays from very finely divided retained austenite, too. The differential thermal analysis and vibrating sample magnetometry techniques also confirmed the stabilization of retained austenite finely divided in bainite/martensite micro-composite microstructures. In addition, the peak temperatures and intensities corresponding to the decomposition of retained austenite were correlated with the related volume fractions and carbon contents measured by the XRD analysis.
Study on Amplitude and Flatness Characteristics of Elastic Thin Strip under Fluid–Structure Interaction Vibration Excited by Unsteady Airflow
Authors: Li Hongbo , Han Guomin , Yang Jingbo , Li Nong , Zhang Jie
Published: April 2019

Based on unsteady airflow excitation and elastic thin strip vibration theory, a SI-FLAT flatness meter was taken as the research object, and an amplitude–residual stress simulation analysis model of the cold rolling strip under aerodynamic loads was established by using ANSYS Workbench. First, the influences of fluid–structure interaction on the strip amplitude distribution and the flatness calculation deviation were analyzed. It was found that the analysis with fluid–structure interaction matched the actual measurement of the flatness meter better. Then, the influences of different aerodynamic loads and tensions on the strip midpoint amplitude and the flatness calculation deviation were analyzed. It was found that when alternating aerodynamic loads increased, the strip amplitude increased in the form of a quadratic polynomial. However, when the tensions decreased, the strip amplitude decreased exponentially. The strip dimensions also influenced the amplitude of vibration: The wider and thinner the strip, the larger the amplitude. Finally, the influences of different flatness defects on the strip amplitude distribution and the flatness calculation deviation were analyzed. The deviation was serious on the strip edge, and the fluctuation characteristics of the deviation were opposite to those of the initial flatness defects.
Phase Formation and Magnetic Properties of Melt Spun and Annealed Nd-Fe-B Based Alloys with Ga Additions
Authors: Shchetinin Igor , Aggrey Patrick , Bordyuzhin Igor , Savchenko Alexander , Gorshenkov Mikhail , Zhelezniy Mark , Menushenkov Vladimir , Mogil’nikov Pavel
Published: April 2019

The structural transformations and magnetic property changes of the Nd16.2FebalCo9.9Ga0.5B7.5 (SG1, SG2) and Nd15.0FebalGa2.0B7.3 (SG3) nanocomposite alloys obtained by melt spinning in the as-quenched state and after annealing at a temperature range of 560–650 °C for 30 min were studied. The methods used were X-ray diffraction analysis, magnetic property measurements, TEM studies, X-ray fluorescence analysis and Mössbauer spectroscopy. Amorphous phase and crystalline phase Nd2Fe14B (P42/mnm) were observed in the alloy after melt spinning. The content of the amorphous phase ranged from 20% to 50% and depended on the cooling rate. Annealing of the alloys resulted in amorphous phase crystallization into Nd2Fe14B and led to the increased coercivity of the alloys up to 1840 kA/m (23.1 kOe) at 600 °C annealing for 30 min. The alloy with the maximum coercivity had a grain size of the Nd2Fe14B phase ≈50–70 nm with an Nd-rich phase between grains.
Study on Friction Stir Lap Welding of Aluminium to Steel Sheets
Authors: Meng Lingfei , Chen Shujin , Zhang Jiaqi , Wang Di , Zhang Hao , Wei Xiaopeng
Published: April 2019

Friction stir lap welding (FSLW) of 6061-T6 aluminium sheet and DX51D galvanized steel sheet was carried out by adding zinc foil to the lap interface and studying the influence of the zinc foil on the formation mechanisms and mechanical properties. The influence of the thickness of zinc foil, the plunge depth of the shoulder and the shape of the tools on the mechanical properties of the weld are discussed. Zinc foil reduced the generation of brittle intermetallic compounds, such as Fe4Al13. During the welding process, the axial force was small due to the high rotating speed. Liquid zinc was retained at the interface, where eutectic Al–Zn with low melting point and an Fe–Zn compound were generated to achieve the metallurgical combination of aluminium and steel. The fracture was located in the heat affected zone (HAZ) of the 6061-T6 base aluminium. The results showed that when the zinc foil was too thin, there was less zinc content at the interface; the resulting Al–Zn eutectic had low melting point, was not fully spread and had poor continuity, resulting in poor mechanical properties. When the zinc foil was too thick, a large amount of zinc-based solid solution was generated at the interface, and most of the fracture occurred in the zinc-rich layer.
Probing the Impact Energy Release Behavior of Al/Ni-Based Reactive Metals with Experimental and Numerical Methods
Authors: Ren Kerong , Chen Rong , Lin Yuliang , Li Shun , Zhang Xianfeng , Dong Jun
Published: April 2019

Reactive metals (RMs) are a new class of material that can withstand mechanical loads and chemically react to release large amounts of heat under strong impact loading. They are gradually becoming widely used in defense and military fields, including for high-efficiency warheads and reactive armor. For the numerical simulation method considering the combined mechanical-thermo-chemical process for the impact energy release behavior of the RMs, the Al/Ni-based RMs were investigated in this work by combining experiments, theoretical calculations and a numerical simulation. Three kinds of Al/Ni-based RMs (Al-Ni, Al-Ni-CuO and Al-Ni-MoO3), were prepared using the hot-pressing forming process. Firstly, the compressive behavior and the parameters of the Johnson-Cook constitutive model were obtained using a mechanical testing machine and split Hopkinson pressure bars (SHPB). Secondly, the parameters of the equation of state (EOS) under the medium and low pressure conditions of the Al/Ni-based RMs, which were was seen as porous mixtures with high theoretical material density percentages (TMD%), were calculated based on the cold-energy superposition theory and the Wu-Jing method. Third, the impact energy release behaviors of the three RMs were studied with direct ballistic tests. The shock temperatures at different impact velocities were calculated based on the existing shock-induced chemical reaction thermo-chemical model while considering the chemical reaction efficiency, the relationship between the shock temperature and the extent of the chemical reaction was established, and the parameters of the relevant chemical kinetic equations were fitted. Finally, the user’s subroutines defining the material model were implemented to update the stresses in the solids elements in LS-DYNA. The model was based on the Johnson-Cook constitutive model with consideration of the mechanical-thermo-chemical coupling effect, which was verified by the experimental results. The results show that the constitutive model developed in this work can describe the impact energy release behavior of the Al/Ni-based RMs.
The Relationship of Fracture Mechanism between High Temperature Tensile Mechanical Properties and Particle Erosion Resistance of Selective Laser Melting Ti-6Al-4V Alloy
Authors: Zhao Jun-Ren , Hung Fei-Yi , Lui Truan-Sheng , Wu Yu-Lin
Published: April 2019

In this study, selective laser melting (SLM) Ti-6Al-4V is subjected to heat treatment for 4 h at 400 °C, 600 °C, and 800 °C, followed by air cooling. After heat treatment at 400 °C and 600 °C, the ductility was lower (strength increased). This was could be for two reasons: (1) high temperature tensile properties, and (2) particle erosion wear induced phase transformation. Finally, the particle erosion rates of as-SLM Ti-6Al-4V and heat treatment for 4 h at 800 °C (labeled 800-AC) were investigated and compared; the lamellar α + β phases in 800-AC are difficult to destroy with erosion particles, resulting in the erosion resistance of 800-AC being higher than that of the martensitic α’ needles in the as-SLM Ti-6Al-4V at all impact angles (even the hardness of the 800-AC specimen was lower). The as-SLM Ti-6Al-4V alloy needs heat treatment to have better wear resistance.