bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Margin Width and Time to Local and Systemic Recurrence of Ductal Carcinoma in Situ
Authors: Shafi Alam Ara , AlMushawah Fatema , Abdalkarim Yousef
Published: January 2023

Background:Recurrence after DCIS treatment is common and half are invasive cancers. Positive excision margin is significantly associated with recurrence, however; debate exists about close margin. We examine the pattern of treatment and recurrences at a single institute.
Objective: To investigate, in women with DCIS treated at KFMC and long follow-up, the relationship between margin width and time to local or systemic recurrence of disease, controlling the other characteristics.
Method:We retrospectively reviewed a prospectively maintained database of DCIS patients treated at single institution from 2014-2018. A multivariable Cox model was used to evaluate the association of margin width with recurrence while controlling for other variables.
Results:We identified 56 cases with a median follow-up of 51 months (range 3 - 120), of which four (7%) had a recurrence within 2 years of initial treatment. Three were invasive ductal cancer while one was high grade DCIS. After controlling the other variables, no association of margin width with recurrence was identified (p-value 0.81) in the current study, however; all recurrences were on the left side (p-value <0.001).
Conclusion:The current study did not identify any correlation between margin width and LR, however; relation between site and LR was statistically significant as more LR was identified in left breast. Low rate of LR in current study could be due to more aged population of patients in present study.
Subducted slabs induce high heat flux at the core-mantle boundary
Authors: Zhao Chengcheng , Manthilake Geeth , Bouhifd Ali , Mathieu Antoine
Published: January 2023

Despite growing evidence suggesting chemically distinct regions and partial melting at the core-mantle boundary (CMB) throughout Earth’s history, current heat-flow models assume a homogeneous thermal boundary layer. To understand probable thermal response of bridgmanite to subducted slab, we measured thermal diffusivity of mid-ocean ridge basalt (MORB)-bearing olivine polycrystalline as an analogy. Our results show a sharp increase of thermal conductivity with an addition of 0.1 vol. % MORB, followed by a systematic decrease with increasing MORB. When the infection point of 1.2–5 vol.% is exceeded, thermal conductivity jump again with 10 vol.% MORB. If it were the case at the CMB, MORB introduced by subducted slab and scattered by mantle flow may have led to lateral variation of heat flux. It results in plume clusters with varying scales, which either grows into superplume with mobile plume root or vanishes when MORB is drained to the infection point.
Altered intestinal microbiota in mice consuming high-fat diets influence cognitive function
Authors: Ma Weiwei , Hua Yinan , Zhou Cui , Fan Rong , Benazzouz Sara , Shen Jiingyi , Xiao Rong
Published: January 2023

This study was aiming to verify critical role of gut microbiota linking diet-induced obesity and cognitive dysfunction. After antibiotic treatment, male C57BL/6 mice were subjected to fecal microbiota transplantation (FMT) using fecal microbiota isolated from donor mice fed on various high-fat diets and control basic diet. Novel object recognition test, 16S rRNA gene sequencing of feces and haematoxylineosin staining of hippocampal CA1 area were performed for all mice. The results showed that donor obese mice induced by diets high in long-chain saturated fatty acid (LCSFA), n-6 polyunsaturated fatty acid (n-6 PUFA) and trans fatty acid (TFA) had significant cognitive impairment (all Ps < 0.05) compared with that in control and n-3 polyunsaturated fatty acid (n-3 PUFA) groups. In recipient mice, the similar effect of above high-fat diets was revealed after FMT, while in absence of obesity. The donor mice in LCSFA, medium-chain saturated fatty acid (MCSFA), n-6 PUFA, and TFA groups showed more structural breakage and less nerve cells in hippocampal CA1 area than that in other groups, which was similar to corresponding recipients. According to these results it was concluded that high LCSFA, n-6 PUFA, and TFA diets may impair the cognitive function by damaging the structures of CA1 region in hippocampal through influencing intestinal microbiota in mice.
Conditions of Inner Planet Formation Inferred From New Estimates of the Sun’s Chemical Composition
Authors: Putirka Keith , Bergemann Maria , Serenelli Aldo
Published: January 2023

Models of inner planet formation assume that their building blocks precipitate from the Solar Nebula, where thermal gradients and planet mass control their bulk compositions. New estimates of the Solar photosphere provide a test of these ideas. We find that none of the inner planets match the Sun’s composition: except for Mercury, the inner planets have less Fe and more Si, Al and Mg. Major elements are also enriched in proportion to their 50% condensation temperatures, which describe 70% of Earth’s variations. But these enrichments are uncorrelated with planet mass, and only O records a heliocentric thermal gradient, while Fe decreases with heliocentric distance. These results imply that above 1,000 K, thermal gradients across the inner Solar System were negligible, and that Fe contents are controlled by the Solar magnetic field. Moreover, knowledge of ambient temperatures and stellar magnetic fields are necessary to improve predictions of exoplanet compositions.
Evaluating the habitat suitability modeling of Aceria alhagi and Alhagi maurorum in their native range using machine learning techniques
Authors: Dastres Emran , Bijani Farzad , Naderi Ruhollah , Zamani Afshin , Edalat Mohsen
Published: January 2023

Spatial locational modeling techniques are increasingly used in species distribution modeling. However, the implemented techniques differ in their modeling performance. In this study, we tested the predictive accuracy of three algorithms, namely "random forest (RF)," "support vector machine (SVM)," and "boosted regression trees (BRT)" to prepare habitat suitability mapping of an invasive species, Alhagi maurorum, and its potential biological control agent, Aceria alhagi. Location of this study was in Fars Province, southwest of Iran. The spatial distributions of the species were forecasted using GPS devices and GIS software. The probability values of occurrence were then checked using three algorithms. The predictive accuracy of the machine learning (ML) techniques was assessed by computing the “area under the curve (AUC)” of the “receiver-operating characteristic” plot. When the Aceria alhagi was modeled, the AUC values of RF, BRT and SVM were 0.89, 0.81, and 0.79, respectively. However, in habitat suitability models (HSMs) of Alhagi maurorum the AUC values of RF, BRT and SVM were 0.89, 0.80, and 0.73, respectively. The RF model provided significantly more accurate predictions than other algorithms. The importance of factors on the growth and development of Alhagi maurorum and Aceria alhagi was also determined using the partial least squares (PLS) algorithm, and the most crucial factors were the road and slope. Habitat suitability modeling based on algorithms may significantly increase the accuracy of species distribution forecasts, and thus it shows considerable promise for different conservation biological and biogeographical applications.
Chatter Stability Improvement of a Slender Milling Tool via a Dynamics Variation Mechanism
Authors: Hayati Sajad , Golmohammadi Masoud , Valitabar Alireza , Rasaee Sajad
Published: January 2023

In this study, a milling tool with variable mass and stiffness is developed for chatter reduction. The proposed milling tool is hollow with a solid core threaded inside it. As the core is screwed in or out of the tool body, the equal mass and stiffness of the tool are changed. Therefore, the tool's frequency response function (FRF) is changed to affect the stability lobe diagram (SLD) position. Moving the SLDs can stabilize an unstable cutting process. With respect to the FRFs obtained from modal test, the idea is proven using an experimental and analytical approach. The optimum core position for every spindle speed is also presented. The developed tool stability is then investigated in a realistic cutting condition. The cutting process sound analysis and surface finish visual inspection results reveal the performance of the proposed system in chatter reduction of a slender milling tool.
Alopecia Areata in Underrepresented Groups: Preliminary Analysis of the All of Us Research Program
Authors: Moseley Isabelle H. , George Elisabeth A. , Tran Megan M. , Lee Hemin , Qureshi Abrar A. , Cho Eunyoung
Published: January 2023

Background
Alopecia areata (AA) is an autoimmune condition characterized by patchy, nonscarring hair loss. Few studies of AA have adequately included participants from underrepresented groups when evaluating the burden of AA in the United States.
Methods and Results
We conducted a cross-sectional study of personal/demographic factors and AA using the ongoing All of Us (AoU) Research Program. AoU enrolls adults over 18 years either as direct volunteers or through participating Health Care Provider Organizations by prioritizing recruiting underrepresented groups. We linked data from surveys and electronic health records (EHRs) to estimate the prevalence of AA by race/ethnicity, physical disability, sexual orientation/gender identity (LGBTQIA+), income, and education. The latest AoU release (version 5) includes 329,038 participants. Average age was 51.8 years (standard deviation, SD 16.7), and 60.2% of participants were female. Of these, 251,597 (76.5%) had EHR data and 752 were diagnosed with AA (prevalence, 0.30%; 95% CI, 0.28–0.32). We used multivariate logistic regression adjusted for age and other factors to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for prevalence of AA. Compared to Whites, Blacks and Hispanics had higher odds of AA (OR, 1.72; 95% CI, 1.39–2.11 and OR, 2.13; 95% CI, 1.74–2.59, respectively). Lower odds of AA were observed in participants with less than a high school degree (OR, 0.80; 95% CI, 0.59–1.08), household income ≤$35,000 (OR, 0.67; 95% CI, 0.54–0.83), and no health insurance (OR 0.35; 95% CI, 0.20–0.56).
Conclusions
In this diverse population of US adults, participants with skin of color had higher prevalence of AA. Lower prevalence of AA among individuals with lower education and income levels and those lacking health insurance may reflect limited access to dermatologic care and potentially higher levels of undiagnosed AA in these groups.
Not every countable complete distributive lattice is sober
Authors: Miao Hualin , xi xiaoyong , Li Qingguo , Zhao Dongsheng
Published: January 2023

The study of the sobriety of Scott spaces has got an relative long history in domain theory. Lawson and Hoffmann independently proved that the Scott space of every continuous directed complete poset (usually called domain) is sober. Johnstone constructed the first directed complete poset whose Scott space is non-sober. Soon after, Isbell gave a complete lattice with a non-sober Scott space. Based on Isbell's example, Xu, Xi and Zhao showed that there is even a complete Heyting algebra whose Scott space is non-sober. Achim Jung then asked whether every countable complete lattice has a sober Scott space.The main aim of this paper is to answer Jung's problem by constructing a countable complete lattice whose Scott space is non-sober. This lattice is then modified to obtain a countable distributive complete lattice with a non-sober Scott space.
In addition, we prove that the topology of the product space ∑P x ∑Q coincides with the Scott topology of the product poset P x Q if the set Id(P) and Id(Q) of all non-trivial ideals of posets P and Q are both countable. Based on this, it is deduced that a directed complete poset P has a sober Scott space, if Id(P) is countable and ∑P is coherent and well-filtered. In particular, every complete lattice L with Id(L) countable has a sober Scott space.
2000 MSC: 54B20, 06B35, 06F30
Maternal and neonatal umbilical cord serum levels of 25-hydroxy vitamin D among Sudanese women with normal pregnancy: a cross-sectional study
Authors: Ahmed Mohamed A , Elmugabil Abdelmageed , AlEed Ashwaq , Al-Nafeesah Abdullah , Adam Ishag
Published: January 2023

There are few published studies on the association between maternal and umbilical cord serum vitamin D concentrations in Sub-Saharan Africans. Therefore, the aim of this study was to assess the association between mothers and umbilical cord 25-hydroxyvitamin D (25-[OH)]D) levels. A cross-sectional study was conducted at the Saad Abuelela Maternity Hospital in Khartoum, Sudan. 90 pairs of mothers and neonates (umbilical cords) were enrolled. The median (IQR) mother’s age and gestational age were 28.5 (26.0‒30.0) years and 38.0 (37.5‒38.2) weeks, respectively. The median (IQR) umbilical cord level of 25-(OH)D was significantly higher than the median maternal level of 25-(OH)D (30.3 [18.2‒38.4] vs. 20.2 [17.5], ng/mL, P = 0.011). Moreover, compared to the maternal samples, a significantly low number of umbilical cord samples had a vitamin D deficiency (≤ 20; 25/90 [27.8%] vs. 42/90 [46.7%], P = 0.013). The umbilical cord 25-(OH)D levels were positively correlated with and significantly higher than the maternal 25-(OH)D levels (r = 0.401).
A Secure Fingerprint Hiding Technique Based on DNASequence
Authors: Al-Ahmadia Wala’a , Aljahdali Asia , Munshi Asmaa
Published: January 2023

DNA steganography is a technique that utilizes the DNA sequence as the basis for the secure transmission of critical data. This technique consists mainly of encrypting and hiding messages within the high capacity of DNA sequences in order to prevent adversaries from reading and decoding secret messages. However, the biometric system is a technological recognition system that processes information about an individual to distinguish them. Biometrics are used in many applications, including fingerprinting, iris scanning, and face recognition. This research will focus on the development of an effective and secure technique that combines steganography and cryptography. This method aims to protect the image of fingerprints in the communication channel while keeping the information confidential. The hiding process of the proposed system converts fingerprint images into a binary series, which is then added to the DNA sequence after applying the appropriate encryption method. The proposed technique utilizes the Feistel network in the encryption process and uses an insertion technique in the hiding process. It has a low cracking probability, high BPN numbers, and good execution times. During the hiding and decoding processes, the proposed system utilizes four different keys, which are chosen randomly, resulting in a high key space and ahigh key sensitivity. The proposed technique increases the noise by adding some random ambiguity bits at random positions in the fingerprint image. The experimental results show that the proposed system is resistant to several attacks, such as known-plaintext attacks and chosen-plaintext attacks. The proposed technique is limited to hiding only a small image inside the DNA and does not handle video, audio, or a large image size.
Induction of anti-tumor immunity by human telomerase reverse transcriptase (hTERT) and viral-derived peptides in breast cancer mouse models
Authors: Kardar Gholam Ali , Songwe Fanuel , Colagar Abasalt Hosseinzadeh , Ghorbani Mehdi , Mohammadi Amir
Published: January 2023

Human telomerase reverse transcriptase (hTERT) is the most common tumor-associated antigen (TAA) and its activity is upregulated in more than 90% of cancers. Therefore, its targeting can be used in cancer immunotherapy. In continuing with our previous study, we evaluated hTERT derived peptides conjugated to KLH in mice breast cancer models. To induce tumors in Balb/C mice, about 5 × 105 mice breast cancer 4T1 cell were washed and suspended in 100 µl sterile PBS and subcutaneously (s.c) injected to 4th mammary fat pat of 6–8 weeks old mice. Thereafter, tumor size measurements were taken two times a week. About 100 ug KLH conjugated peptides accompanied by Incomplete Freund′s adjuvant (IFA) were injected s.c on days 10th and 20th after cancer cells inoculation. In spite of their significantly lower immunogenicity and affinities on mice HLA compared to human (approximately 5–30 times), these peptides inhibited tumor growth as well as being able to increase the overall survival of vaccinated Balb/C mice compare untreated group.
From differential and perfect differential to Roman domination and perfect Roman domination in probabilistic neural networks
Authors: BERBERLER Zeynep Nihan
Published: January 2023

Let G = (V, E) be a graph of order n. Let B(S) be the set of vertices in V\S that have a neighbor in the vertex set S. The differential of a vertex set S is defined as ∂(S) = |B(S)|−|S| and the maximum value of ∂(S) for any subset S of V is the differential of G. For S ⊆ V(G), the set Np(S) is defined as the perfect neighborhood of S such that all vertices in V(G)\S have exactly one neighbor in S. The perfect differential of S is defined to be ∂p(S) = |Np(S)|−|S| and the perfect differential of a graph is defined as ∂p(G) = {∂p(S)⊆V(G)}. A Roman dominating function of G is a function ƒ:V → {0,1,2} such that every vertex v for which ƒ(v) = 0 has a neighbor u with ƒ(u) = 2. The weight of a Roman dominating function ƒ is w(ƒ) = ∑v∈Vƒ(v). The Roman domination number of a graph G, denoted by γR(G), is the minimum weight of all possible Roman dominating functions. A perfect Roman dominating function is defined as an Roman dominating function ƒ satisfying the condition that every vertex u for which ƒ(u) = 0 is adjacent to exactly one vertex v for which ƒ(v) = 2. The perfect Roman domination number, denoted by γPR(G), is the minimum weight among all perfect Roman dominating functions on G, that is γPR(G) = min{w(ƒ):ƒ is a perfect Roman dominating function on G}. This paper is devoted to the computation of differential, perfect differential and Roman domination, perfect Roman domination of probabilistic neural networks by the use of the proven Gallai-type results γR(G) = n−∂(G), γPR(G) + ∂P(G) = n. Besides, existing Roman and perfect Roman graph classes of probabilistic neural networks are characterized.
2020 Mathematics Subject Classification: 05C69, 05C05, 05C82
Pressure dependence of elastic constants of wurtzite Indium Nitride semiconductor
Authors: Mukherjee Prabir K. , Tripathi Gouri S.
Published: January 2023

In this work, we study the pressure dependence of elastic constants ofwurtzite Indium Nitride semiconductor based on the Landau free energyexpansion. Elastic constants are obtained as functions of pressure up tosecond order. However, departure from nonlinearity is found to be small for acarefully chosen set of model parameters. Agreement with previously obtainedresults based on first-principles calculations is found to be satisfactory.
Meaning-making strategies for text reading during bilingual science teaching
Authors: Axelsson Feyza , Ünsal Zeynep , Jeppsson Fredrik
Published: January 2023

This article concerns how different meaning-making strategies are used and related to each other during text reading in bilingual science teaching. A qualitative case study approach was adopted in order collect data in a public school in Sweden. Non-participant observations were made when a Turkish-speaking nineth grade (15-year-old) emergent bilingual student received additional lessons in his mother tongue in addition to regular monolingual science lessons. The purpose of the bilingual science teaching was to support the student’s meaning-making of a text about atoms. A narrative analysis shows how five meaning-making strategies were used and related to each other in various ways, depending on the context. The conversations often started with the meaning-making strategy of questioning. In some situations, relating questioning to rereading without the teacher giving any additional information resulted in the student making meaning. In other situations, this was not enough, and further meaning-making strategies were needed, namely using examples, reformulating, and translating. The bilingual science teaching enabled the student to use his whole language repertoire to make meaning of the text content. Typically, the participants read the text in Swedish and then talked about it in Turkish. However, their discussions about the meaning of scientific concepts did not follow this pattern. Scientific concepts were sometimes kept in Swedish and sometimes translated into Turkish. The translations were continuously related to everyday situations by using examples and reformulation as meaning-making strategies. This detailed analysis of the strategies used contributes to an increased understanding of the meaning-making process in text reading during bilingual science teaching. Educators might draw on these findings to support emergent bilingual students in similar situations.
HSI-IPGAN: Hyperspectral Image Inpainting via Generative Adversarial Network
Authors: Chen Hu , Li Jia , Zhang Junjie , Zhang Liangang , Zeng Dan
Published: January 2023

Due to the instability of the hyperspectral imaging system and the atmospheric interference, hyperspectral images (HSIs) often suffer from losing the image information of areas with different shapes, which significantly degrades the data quality and further limits the effectiveness of methods for subsequent tasks. Although mainstream deep learning-based methods have achieved promising inpainting performance, the complicated ground object distributions increase the difficulty of HSIs inpainting in practice. In addition, spectral redundancy and complex texture details are two main challenges for deep neural network-based inpainting methods. To address the above issues, we propose a novel inpainting model based on generative adversarial networks for HSI (HSI-IPGAN). To reduce the redundancy of spectral information, a multi-frequency channel attention module is designed to strengthen the essential channels and suppress the less significant ones, which calculates adaptive weight coefficients by converting feature maps to the frequency domain. Furthermore, we propose to constrain the generation of missing areas from both global and local perspectives, by fully leveraging the HSI texture information, so that the overall structure information and regional texture consistency of the original HSI can be maintained. The proposed method has been extensivelyevaluated on the Indian Pines and FCH datasets. The promising results indicate that HSI-IPGAN outperforms the state-of-the-art methods in quantitative and qualitative assessments.
Numerical assessment of the static and dynamic response of the basilica of St. Sotiri
Authors: Bilgin Huseyin , Fule Zelina
Published: January 2023

Basilicas constructed in the post-Byzantine time in Balkans cover a period of 400 years, from the 16th century to the 19th century. These masonry religious objects are of particular interest due to their different building typologies, so it is important that they be saved for future generations. This paper analyses the static and dynamic response of the Basilica of St. Sotiri near Gjirokaster (Albania). The static response and dynamic properties of the church have been assessed using FEM technique. As a result, important information is obtained to determine the critical regions of the structure and the performance of the structure is investigated. The aim of this study is to point out that sophisticated numerical analysis methods can provide clear insight and information on interpreting the actual response of historical buildings. Authors believe that the approach and findings of this case study are applicable to a wide range of monumental churches.
Impact of Race and Ethnicity on Length of Stay, Discharge Location, and Total Charges for Inpatients with Skin Ulcers in New York
Authors: Hardy Nicole J. , Gronbeck Christian , Feng Hao
Published: January 2023

Background
Black patients receiving outpatient care for skin ulcers are less likely to see a physician and are at risk for higher stage pressure injuries. While racial/ethnic differences in outpatient treatment of skin ulcers has been described, this study aims to elucidate potential differences in the inpatient setting using publicly-available data.
Methods
We conducted a retrospective cohort study of the Statewide Planning and Research Cooperative System database, a de-identified, patient-level dataset for inpatient visits in New York between 2009–2021. Admissions were filtered by diagnosis-related group (APR-DRG) code 380 (skin ulcers).
Results
Compared to white patients, Black patients demonstrated longer mean LOS (8.15 vs. 7.44 days, p = 0.003), higher mean charges ($44,800 vs. $37,600, p < 0.001), and were more frequently discharged home without services (38.4% vs. 33.0%, p < 0.001). Hispanic patients had shorter mean LOS (6.92 vs. 7.64 days, p = 0.006), similar hospital charges, and were also more frequently discharged home without services (46.1% vs. 34.8%, p < 0.001). After adjusting for patient factors, Black patients had a longer LOS by 0.29 days (p = 0.011) with $2,836 higher inpatient charges (p < 0.001) whereas Hispanic patients had a shorter LOS by 0.30 days (p = 0.038) with $2,402 lower total charges (p = 0.004).
Conclusions
The findings suggest racial and ethnic differences in hospitalizations for skin ulcers, with Black patients experiencing greater LOS and charges. The reasons for these differences merit investigation, yet could be related to delays in outpatient care, more severe disease, presence of comorbid conditions, or complications requiring intensive inpatient services.
Practical biomarkers and robust multiplex models for the prediction of response to promising first-line chemotherapy: A theranostic study in metastatic ovarian cancer patients with residual peritoneal tumors
Authors: Kawabata-Iwakawa Reika , Iwasa Norihiro , Satoh Kenichi , Colinge Jacques , Shimada Muneaki , Takeuchi Satoshi , Fujiwara Hiroyuki , Eguchi Hidetaka , Oishi Tetsuro , Sugiyama Toru , Suzuki Mitsuaki , Hasegawa Kosei , Fujiwara Keiichi , Nishiyama Masahiko
Published: January 2023

Background:In advanced or metastatic ovarian cancer patients, the therapeutic impact of molecular targeted agents and immunotherapy is limited, and current chemotherapeutic algorithms are still far from personalized medicine.We recently demonstrated that intraperitoneal carboplatin with dose-dense paclitaxel (ddTCip) therapy is a promising front-line chemotherapy even in patients with residual peritoneal tumors, which led us to this theranostic study for biomarker discovery to realize precision medicine (ID: UMIN000001713 on Feb 16th, 2009).Methods:We first validated previously suggested markers (41 genes and 3 predictive models for therapeutic efficacy and 31 polymorphisms for toxicity), sought out more active effective biomarkers through genome-wide transcriptome and genotyping analyses, and then developed multiplex statistical prediction models for progression-free survival (PFS) and toxicity. Multiple regression analysis following the forward stepwise method and the classification and regression tree (CART) algorithm were mainly employed to develop multiplex prediction models.Results:The association analyseswith PFS in 76 patients followed by the validation study using data sets in 189 patients published in The Cancer Genome Atlas revealed thatSPINK1expression could be a possible predictive biomarker of ddTCip efficacy even when used alone, and multiple regression analyses provided a potent efficacy prediction model using expression data of 5 genes. SPINK1 appeared to be a critical resistant determinant of ddTCip therapy, which indicates the potential of SPINK1 as a novel therapeutic target. For toxicity prediction, ABCB1 rs1045642 and ERCC1 rs11615 polymorphisms appeared to be closely associated with grade 2-4 hematologic toxicity and peripheral neuropathy, respectively. We further successfully composed robust multiplex prediction models for adverse events - CART models using a total of 4 genotype combinations and further powerful multiple regression models using 15 polymorphisms on 12 genes-.Conclusions:We newly proposedSPINK1expression as a powerful predictive biomarker of the efficacy of ddTCip therapy and confirmed the predictive values ofABCB1and/orERCC1polymorphisms for toxicity. The multiplex prediction models composed herein were also found to work well for the prediction of therapeutic response.These findings may raise the potential to realize precision medicine in the essential treatment for metastatic ovarian cancer patients.
Lower COVID-19 incidence in Bulgaria in 2022 can be attributed to the Delta variant's belated intense spread.
Authors: Getsova Zhivka , Kamenov Galin , Bogdanov Nikolay , Rangelova Vanya
Published: January 2023

Objectives
The first COVID-19 wave caused case fatality rates (CFRs) of above 7% globally. In 2021 and 2022 the values of the same indicator went down to 2%. Differences between countries are still observed. The present study aimed to assess the CFRs dynamics in Bulgaria in relation with the specificity of the epidemic process in the country.
Methods
Descriptive analysis of cumulative incidence, mortality rates, and hospital admissions during the Delta and Omicron waves in Bulgaria and in the EU was performed. Differences in stringency index and testing capacities were analyzed to provide reasoning behind the findings. Indicator values were compared temporally and quantitatively.
Results
Data was reviewed for 27 EU countries. Opposing trends in Bulgaria and in the EU were reported. During the Delta wave incidence in Bulgaria was 25% higher than in the EU and increased by 67% during the Omicron period. In the EU, the increase during the Omicron wave was five-fold. Mortality in Bulgaria decreased by 38% between the two waves but it continued to be above the median mortality rate in the EU. Hospital admissions followed similar trends. Out of 16 countries only 5 experienced a drop of the number of new hospital patients. In Bulgaria admissions shrank by 45% during the Omicron predominance.
Conclusions
Higher incidence during the Delta wave resulted in accumulation of population with recently obtained natural immunity. Given evidence from countries with good vaccination coverage, it is reasonable to conclude that some of the mortality in Bulgaria could have been averted. Due to the observed positive association between acceptance of vaccines and other anti-epidemic measures, we recommend that future risk communication efforts highlight the importance of personal decision-making and social behaviour.
Green Synthesis and Antibacterial Activity of Silver Nanoparticles: A Review
Authors: Nandiyanto Asep Bayu Dani , Nabila Annisa Moza , Nindya Faradhina Salfa , Berliana Nur'aini , Oktaviani Nur Shafa , Khoiriah Selmi Fiqhi , Kurniawan Tedi
Published: January 2023

The purpose of this study was to determine the effect of silver nanoparticles (AgNPs) from different green synthesis medium and their various particle sizes on antibacterial activity. The article review method compares the results of 11 studies obtained from the PubMed database, Web of Science, and ScienceDirect indexed by Scopus in the last five years. The search was conducted based on the phrases nanoparticles, antibacterial, Green synthesis, and AgNPs. Green synthesis of AgNPs with various plant extracts produces different sizes of nanoparticles. The smallest size AgNPs were obtained in the range of 5-15 nm and an average of 13 nm extracted using the leaves of the Pacific Yew tree (Taxus brevifolia). Meanwhile, AgNPs with the best antibacterial effectiveness were obtained from the Blume flower extract (Wedelia urticifolia) measuring less than 30 nm providing a zone of inhibition for S. aureus, K. pneumoniae, E. coli, and P. aeruginosa bacteria.
Synthesis of Bioplastics on Rice Straw Cellulose Using Orange Peel Extract, Chitosan, and Sorbitol
Authors: Chadijah Sitti , Harianti Harianti , Febryanti Amalyah , Alif Alfiah , Maulidiyah Maulidiyah , Umar Akrajas Ali
Published: January 2023

With the use of several plasticizers (orange peel extract, chitosan, and sorbitol), rice straw cellulose has been used to synthesize and characterize bioplastics. This study aims to synthesize and characterize bioplastics from rice straw cellulose with various additions of plasticizers, namely orange-peel extract, chitosan, and sorbitol, each with a certain concentration so that quality improvement can occur. The methods used in this study include testing the tensile strength value, testing the percentage elongation, and testing the percentage of biodegradation. In addition, functional group characterization tests were also carried out using FTIR. The results obtained in this study were the best values for tensile strength and percentage elongation in treatment A, namely 10.2611 MPa and 13.88%. The percentage of biodegradation for 7 days reached 50.58%. Functional group absorptions were found in various plasticizers, namely C-H, O-H, C-O, C-N, and C=C. Based on existing data, bioplastics synthesized using rice straw cellulose in various plasticizers meet JIS (Japan Industrial Standards).
Penerapan Algoritma K-Means Clustering Analysis Pada Penyakit Menular Manusia (Studi Kasus Kabupaten Majalengka)
Authors: BASTIAN ADE
Published: January 2023

Kesehatan merupakan hal yang berharga bagi manusia karena siapa saja dapat mengalami gangguan kesehatan, begitu  pula  pada manusia yang sangat  rentan  terhadap  berbagai  macam  penyakit namun penyebabnya tidak kita sadari. Algoritma  K-Means  tidak  terpengaruh  terhadap  urutan  objek yang digunakan, hal ini dibuktikan ketika penulis mencoba menentukan secara acak titik awal pusat cluster  dari  salah  satu  objek  pada  permulaan  perhitungan.  Jumlah  keanggotaan  cluster  yang dihasilkan  berjumlah  sama  ketika  menggunakan  objek  yang  lain  sebagai  titik  awal  pusat  cluster tersebut. Namun, hal ini hanya berpengaruh pada jumlah iterasi yang dilakukan. Pengelompokan  objek  (objek  clustering) adalah salah satu proses dari  objek  mining yang bertujuan untuk mempartisi objek  yang ada kedalam satu atau lebih  cluster  objek  berdasarkan karakteristiknya.Penelitian  ini  mengkaji bagaimana  penggunaan  Algoritma  K-Means Cluster  Analysis  dalam studi kasus penyakit menular manusia pada  suatu  objek. Penelitian ini mengkaji metode K-Means Cluster  Analysis dalam penyakit menular pada manusia berdasarkan set variabel  yang dibentuk per kecamatan tiap puskesmas yang jumlahnya ada 32 Kantor Puskesmas di Kabupaten Majalengka.
Women in Disasters: Unfolding the Struggles of Displaced Mothers in Talisay, Batangas during the Taal Volcano Eruption and the Pandemic
Authors:   Polytechnic University of the Philippines, Manila, Philippines, Ancheta Jeffrey Rosario , Gamayo George Vincent
Published: January 2023

Disasters strike globally, but their impacts are often more severe on socially and economically marginalized sectors like women. This is one of the main justifications behind the 2010 Philippine Disaster Risk Reduction and Management Act, which promotes gender equality and inclusivity in all strategies to combat the adverse effects of natural hazards, especially on underrepresented populations. However, gender-based discrimination during disasters is still prevalent in local communities of the Philippines. Thus, this study attempts to unfold the struggles of displaced mothers in Talisay, Batangas, because of the Taal Volcano’s eruption in January 2020 and worsened by the COVID-19 pandemic that began in March 2020. Specifically, this study identifies the direct impacts that impede survivors’ capacity to recover from the disruptions brought about by the aforementioned catastrophes. Findings, through mothers’ narratives, reveal six (6) key themes that reveal insecurity in livelihood, shelter, education of their children, food, health and nutrition, and water, sanitation, and hygiene (WASH). This only proves that displaced mothers face socio-economic issues aggravated by the changing climate that the local government of Talisay needs to address towards a gender-inclusive DRRM.
Spectres of Caste/Contagion: Death Anxiety and Caste Anxiety in U.R. Ananthamurthy’s Samskara
Authors:   Department of Humanities and Social Sciences, IIT Roorkee., Thiyagaraj G. , Mishra Binod ,   Department of Humanities and Social Sciences, IIT Roorkee.
Published: January 2023

The article critiques the traversal politics of caste and contagion through a critical dissection of what comes as a primarily biomedical excess of the outbreak—the dead body. It elucidates upon the becoming of the dead body into an untouchable where its “right to die with dignity” is deferred. The article reasons this stigmatisation of the deceased as a result of anxiety ensued in the living population facing the outbreak crisis. Through a close textual reading of U.R. Ananthamurthy’s novel Samskara (1965), the article elaborates on the othering discourse of outbreaks and discusses the type of socio-immune response exhibited by a casteist body politic. The novel centres its narrative around a plague-stricken Brahmin community where the contested dead body of pestilence triggers an endless debate of humanistic morals and ethics. By equipping the Derridean lens of hauntology, the article reads Samskara as an outbreak narrative which informs about the social unpreparedness and indecisiveness expressed by caste groups. The article discusses two types of anxieties expressed in such a caste-based society, namely death anxiety and caste anxiety. It mediates how these anxieties are produced in inversion, creating a unique pattern of social instability and inertia with relevance to the socio-political discourse of India. The epiphenomenon of inverted anxieties in India is presented as a subverted narrative from the global patterns of anxiety charged by microbial invasions. Finally, the article examines how the dead regains spectral agency in order to reveal the social pathology of a community doubly infected with caste and contagion.
The English Language Limits Me! Connecting Third Space to Curriculum Transformation in a South African University, Expanding Epistemological Landscapes?
Authors:   University of Fort Hare, South Africa., Kepe Mzukisi Howard
Published: January 2023

Many studies were conducted on conventional colonial heritage; however, less attention examines the developing concept of curriculum decolonisation in South African universities. This paper advocates for a hybrid literacy between traditional conceptions of academic literacy and instruction for students’ sociohistorical lives, affluent and less affluent. I discuss and illustrate the hegemony of English in high-learning institutions and the post-apartheid mainstream education system. Alongside my previous work in the language field, I interrogate the impasse of language policy in high education and South African schools. This paper is an ethnographic study congruent with the interpretivism paradigm, employing the semi-structured interview for data collection. The third space supports it as a theoretical framework. It affords the provision and guidance for classroom instruction and autonomous learning modes balance, where developing new knowledge is heightened, allowing students’ voices. It is a response to the 2015-2016 student protests on South African university campuses, where several were perplexed on how to respond to the demands of the students to end violent protests against western disciplinary norms that devalue non-centre practices and themes. Biliteracy and translingualism are empathised as the concepts against ownership of language and culture, and its territorialisation, challenging the traditional contrast of ‘native’ and ‘non-native’ speakers and its connection to a particular nation-state.
Afghan Women and the Taliban: Tracing Questions of Legal Rights, Insecurity and Uncertainty in Select Texts vis-à-vis the Current Crisis
Authors:   Department of Liberal Arts, Humanities & Social Sciences, Manipal Academy of Higher Education, Manipal, India, B.N. Anupama , Dutta Chowdhury Payel ,   School of Arts, Humanities & Social Sciences, REVA University, Bengaluru, India
Published: January 2023

The status of Afghan women has been a subject of academic interest primarily because of the strict patriarchal hegemony that they have been subjected to. Afghanistan has seen enormous changes in the last four decades due to multiple invasions, wars, and terrorism. 15th August 2021 marks a significant transition in the Afghan socio-political scenario with the Afghan government collapsing as Taliban took over Kabul. The Taliban’s initial public statements after seizing power included assurances on allowing women their rights within the framework of Shari’a Law. Against this backdrop, this paper examines the actual status of Afghan women’s legal rights and security concerns at present after the completion of one year of the Taliban take-over. The study delves into an exploration of the changing dynamics of women’s status in real-life vis-à-vis such portrayals in select literary texts by Khaled Hosseini and Atiq Rahimi to understand how their narrative spaces mirror the socio-political conflicts in Afghanistan. Drawing upon Gender Studies and discourses concerning masculinity and femininity, particularly studies conducted on women and violence, and the UN Women’s reports on gender alert published in December 2021 and August 2022, this paper aims to explore the fictional space in relation to the real-life scenario in Afghanistan.
Religious Heritage: Reconciliation between Spirituality and Cultural Concerns
Authors:   Department of Social Anthropology, University of León (Spain)., Fernández-Álvarez Óscar , González-González Miguel ,   Department of Social Anthropology, University of León (Spain), Ouali-Fernández Sara ,   Department of Social Anthropology, University of León (Spain).
Published: January 2023

Religious heritage has a dual cultural and religious meaning and importance in society. It has a cultural value because it symbolises the history and art of a community, and a religious value because it represents a spiritual hub and home for a community of believers. This article analyses the challenges posed by this association between religious heritage —as both an economic and tourism resource— and cultural heritage. Methodologically, an observation, reflection and analysis of the challenges that are faced are proposed. The results reveal various initiatives for development, protection and enhancement. The discussion revolves around the importance of community involvement and the benefits this brings to various sectors, including economic activity, from the perspective of religious tourism as an aspect of tourism per se, in which a faith and its believers are elements that merit heritage conservation.
Aspects and Dimensions in Collaborative Approach: To Improve Research Discovery in Digital Arts and Digital Humanities
Authors:   Universitas Negeri Makassar, Indonesia., Bosra Mustari , Sumarsih  , Manap Somantri , Abdu Wamaungo Juma
Published: January 2023

Utilizing casual local area assessment and insight contraptions, as well as the improvement of the field of automated workmanship since 2013, this paper expects to look at the design, examples, and subjects of cross-public joint efforts in Digital Humanities research. This contains works from the Web of Science Core Collection as of December 2018 in the field of computerized humanities. The discoveries demonstrate the fact that there is a lot of global cooperation in the field of computerized humanities research; the conveyance among nations is lopsided. In this article, we explicitly audited the accounts and discoveries that have been made during the advancement of this specific field of examination, looking at how much they can or ought to be re-examined considering the post-computerized culture where we get ourselves as a part of post-humanistic thinking. This study utilized various informatics procedures and advances to distinguish the examples, subjects, and designs of the global joint effort in digital humanities research and digital art.
Colonialidade como fato social total
Authors: Trindade da Silva Lucas
Published: January 2023

Em um esforço de explicitar a teoria social produzida por Aníbal Quijano, buscarei demonstrar como a colonialidade, quando lida como fato social total, é fenômeno abarcador, presente em experiências individuais – seja em diversas formações sócio-nacionais seja de mulheres e homens em particular – e que, mutatis mutandis, confere a tais experiências uma significação global ou um caráter de totalidade, imiscuindo-se nas dimensões sincrônico-estrutural (da ordem), diacrônico-histórica (da mudança), corpóreo-psíquica (subjetividade), assim como onto-epistemológica (metateórica).
As articulações internominais na construção de sentidos para família em formações nominais
Authors: Rodrigues Mara , Zattar Neuza
Published: January 2023

O presente trabalho resulta de uma parte da pesquisa realizada junto ao Programa de Pós-Graduação em Linguística – Unemat, e se propõe a analisar como se dá a significação da formação nominal família constituída por articulações internominais em textos que circulam na internet. Partimos da formulação de que a significação não é algo pronto e acabado e que o homem precisa significar o tempo todo. Tomamos como aporte teórico a Semântica da Enunciação desenvolvida por Guimarães (2002; 2018) e os estudos enunciativos de Dias (2018) sobre a formação nominal, definida como “uma formulação articulatória que abriga um campo de pertinências entre o memorável e a atualidade do dizer.” (DIAS, 2013, p. 214). O procedimento de análise adotado é o das redes enunciativas, que são lugares de observação do funcionamento do nome, ou seja, lugares que podem fornecer visibilidade na produção de um enunciado.
O papel do hemisfério direito no processamento de inferências: o que dizem os estudos cerebrais?
Authors: Franzen Bruna Alexandra , Roberto Dohane , Tomitch Lêda Maria Braga
Published: January 2023

O presente artigo tem por objetivo mapear trabalhos que, nos últimos doze anos (2009-2021), têm investigado as redes cerebrais ativadas no processo de construção inferencial, voltando especial atenção para o papel do hemisfério direito. Para tanto, foi realizada uma busca no Portal de Periódicos Capes e PubMed, que retornou quinze artigos, dos quais onze atenderam aos requisitos para análise. Tendo por base os modelos de compreensão de Gagné et al. (1993) e de Kintsch e Rawson (2013), apresenta-se e discute-se o que os estudos trazem em torno da realização de inferências, do estabelecimento da coerência e das bases neurais envolvidas nesses processos. A discussão efetuada aponta para um envolvimento superficial do hemisfério direito na maioria dos estudos, indicando uma atuação em conjunto de ambos os hemisférios. Ressalta-se, contudo, que as pesquisas aqui reportadas não trabalham com porções textuais maiores e isso pode ser um fator importante no que tange ao papel do hemisfério direito no processamento de níveis superiores de leitura.
O discurso sobre masculinidade tóxica em uma campanha publicitária governamental
Authors: Araújo Oliveira Fábio , De Jesus Santos Nádia
Published: January 2023

Neste artigo, o objetivo é analisar o discurso sobre a masculinidade tóxica em três peças publicitárias da   campanha “Nova Masculinidade”, realizada pelo Governo do Estado da Bahia em 2019, como ação de prevenção à violência contra mulheres. Para isso, utiliza-se o arcabouço teórico-metodológico da Análise de Discurso de linha francesa, enfocando a constituição, formulação e circulação dos sentidos sobre esse tipo de masculinidade. Com a análise, é possível perceber que a memória dos estudos de gênero, dos estudos das masculinidades e dos movimentos sociais que lutam contra a violência de gênero sustentam os enunciados da campanha em questão. Além disso, os sentidos constituídos e formulados circulam em espaços com grande movimentação de uma diversidade de pessoas, o que poderia favorecer na ressignificação do objeto discursivo "masculinidade'', proposta pela campanha. Entretanto, “Nova Masculinidade” é da ordem do acontecimento, não entrando para a regularidade da memória.