bluuebunny/crossref_metadata_2025 huggingface dataset:
Kryzys, krytyka, mądrość. Kantowskie ujęcie mądrości i jego aktualność
Authors: Jacyk Dominika
Published: August 2021

The title concepts of criticism, crisis, and wisdom are taken from the paradigm of Kantian philosophy and are characterised in the development given by the contemporary philosopher Odo Marquard. In this connection I present the relationship between wisdom and thinking in the Enlightenment usage. The call for philosophy to be self-understanding in the sense of the Enlightenment Bildung and the autonomy of science and wisdom sounds particularly strong here. I conclude that philosophy becomes stupidity when it turns into a field that—because of some kind of philosophical fundamentalism—would like to become this one-sided attitude towards reality that eliminates and replaces other attitudes.
The Sufi Ethics of Annihilation and Responsibility in Al-Jabri’s Critique of the Arabic Ethical Mind
Authors: Khirallah Issam
Published: August 2021

The paper outlines the interpretation of Sufism formulated by Mohamed Abed Al-Jabri, a contemporary Moroccan philosopher and critic of the Arabic tradition. According to him, Sufism, unknown to Arabic culture until the advent of Islam, originated through a historical conspiracy whereby the Persians attempted to weaken their new Arabic colonisers. Sufism is viewed by him as an evasion and a detachment from life and its problems. It leads its adepts, through the mystical journey, to renounce material life. It plunges its adepts into a way of life where the annihilation of the self in God represents the central value. This annihilation of the self in deity is possible only through the blind obedience of the Seeker (Mureed) to his Master (Sheikh). Therefore, Sufism can only thrive by using tyrannical means. It demands that its adepts, through following a predestined path chosen by God, lose their own volition and freedom in favour of their Master. Breaking the law at the end of the Seeker’s mystical journey reflects, paradoxically, a spiritual accomplishment. Additionally, Sufi orders maintain a congenial relationship with political tyranny. Consequently, I argue, Sufism leads to a loss of human responsibility for oneself and other beings. I also claim that in a post-tyrannical Arabic society, where responsibility for oneself and one’s community should be the centralvalue, Sufi ethics are unable to play a role in the promotion of modern values. For this reason, it should be prevented from shaping the political and social choices of a modern society and constrained to the mystical realm.
Efficiency of the Diesel engine fuelled with the advanced biofuel Bioxdiesel
Authors: POPRAWSKI Wojciech , STRUŚ Mieczysław Stanisław
Published: August 2021

One way to reduce the negative impact of internal combustion engines on the environment is to use advanced biofuels, e.g. Bioxdiesel which is a mixture of Fatty Acid Ethyl Esters (FAEE), bioethanol and standard diesel, with vast majority of the content with biological origin. The FAEE are promising content of the Diesel-Biodiesel-Ethanol blends. The FAEE can be obtained from both vegetable, eg. rapeseed oil and animal fats, as well as waste fats.
The article presents research results on the efficiency of a turbocharged Diesel engine equipped with a Common Rail fuel injection system which was powered by Bioxdiesel fuel and for comparison purposes also fed with standard fuel. The effects study showed that even with a lower calorific value of Bioxdiesel fuel when compared to that for the standard diesel, the overall engine efficiency obtained during the test results was comparable to the standard fuel. Due to the presence of oxygen in the particles of the biofuel, and thus more efficient combustion processes, for a wide range of the minor engine load, the fuel consumption of Bioxdiesel and Diesel fuels was comparable to each other, while at higher engine load the fuel consumption of Bioxdiesel was lower than that for the other fuel.
Diagnostic Patterns of Suspected Covid-19 Patients Using Scor Covid-19, PCR Test and Serological Test in Dr. Soetomo Hospital Surabaya, Indonesia
Authors: Hadi Usman , Bramantono Bramantono , Vitanata M , Rusli Musofa , Rahman Brian Eka , Asmarawati Tripudi , Marfiani Erika , Triyono Erwin Astha
Published: August 2021

Objective: To find out the diagnostic pattern of COVID-19 using RT-PCR or a rapid antibody test in the suspected group patients.Method: The study was conducted in  Dr. Soetomo General Hospital (referal hospital for covid-19, 1500 beds). The study used data on patients with suspected covid-19 who were hospitalized at the Dr. Soetomo General Hospital in Surabaya.Result: There were 200 suspected COVID-19 patients enrolled in this study, the main complaints of cough, fever, dyspnoea, around 69.5%, 75%, and 76.5%, respectively. Although not a common symptom, it seems that anosmia (14%) is typical for COVID-19. Based on this scoring system, a total of 196 patients had a high risk of being infected with COVID-19, and 125 (64%) of them finally showed a positive PCR test. PCR test mostly positive (62.5%), while serological test (rapid imunoglobulin test) mostly non reactive, but there were nonsignificant different between PCR and Serological test (p=0.16 OR: 1.5(0.84-71). Furthermore, if we compare the various existing variables, namely the covid-19 score, immunoglobulin rapid test, and radiological examination, only the radiological examination results can be used as a strong predictor of positive PCR results (p=0.005, OR: 1.68 (0.17-16.43).In this study, we found that abnormal chest radiographs are a good parameter for diagnosing COVID-19, (OR: 2.92; 95% CI, 1.34 -6.34).Conclussion: The initial radiological examination combined with the clinical symptoms of Covid-19 is the most important thing to predict the presence of this disease.
Palate Fracture Profile	in Plastic Reconstructive and Aesthetic	Surgery of	Soetomo Hospital : January 2012 – December 2017
Authors: N. Priscilla Valentine , Budi Agus Santoso , Zarasade Lobredia
Published: August 2021

Background: Palatal fractures are often associated with maxillofacial fractures and Le Fort fractures. The diagnosis and management of palatal fractures in the midface area is a challenge for a plastic surgeon in restoring function and aesthetics. With the results of this study, it is expected to be a database of maxillofacial fractures treated at SMF Reconstructive Plastic Surgery and Aesthetic Dr. Soetomo, Surabaya and gave the ability to make a fast and precise diagnosis for time and technical maxillofacial fractures.Methods : This study uses medical record data for all patients diagnosed with palatal fractures in Dr. Soetomo General Hospital, Surabaya during January 2012 to December 2017. The variables studied were demographic data including sex, age, mechanism of occurrence of accidents, types of fractures, management, complications that occur and length of treatment.Results : There were 82 patients with palatal fractures, with traffic accidents being the most common cause of palate fracture (n = 61) followed by workplace accidents and households in second place (12 and 9%). Most sufferers were men (68%), women (14%) with the highest age range of men aged 19-30 years who were followed by ages 31-45. The most were parasagittal fractures (56%), then Sagittal (15%), paraalveolar (9%), alveolar (1%), comminutive (1%). no fractures with anterior and posterolateral alveolar types, posterolateral type or transverse type fractures. Hospitalization period with plating (12 days), transmolar wiring (10.6 days), conservative (13.8 days).Conclusions: In this study assessed the experience in the reconstruction and aesthetic plastic surgery department of Dr. Soetomo General Hospital regarding palatal fractures and accompanying demographic data. The type of fracture that occurs is also related to the management performed. Incomplete medical records caused problems in this study.
Split Lateral Forehead Flap for Reconstruction of Upper and Lower Eyelids
Authors: Pramana I G. A. N. Widya , Rizaliyana Sitti
Published: August 2021

Background: Eyelids reconstruction after tumor resection has be one of the most challenging procedures in reconstructive plastic surgery. Small defects may be closed by primary suture or covered by small local flaps or skin graft. But in large eyelids defects, we need to find a bigger source of color and texture matching tissue that will ensure functional and aesthetical outcomes. Many techniques have been described, but in this case, the author suggest a split lateral forehead flap designed to cover upper and lower eyelids. Patient and Operation Techniques: A Male 51 years-old-patient, presented himself in our clinic with a basal cell carcinoma involving the right upper and lower eyelids. The tumor had a history of 7 years, without any pain or vision disorders involved. Tumor was widely excised, leaving a full thickness on upper and lower eyelids. The inner lining palpebral was replaced by composite auricular graft following by lateral cantophexy. A lateral forehead flap raised with a right temporal pedicle, and the distal part of flap was split in half, and inset into the upper and lower eyelids defect. The donor region was closed with an STSG from Femur Dextra. After 14 days the flap was divided, the functional result was excellent. Discussion: At first, surgeons were worried of raising forehead flaps beyond the midline, fearing that by splitting the distal flap would cause its compropmise. However, rich anastomostic plexus exists between the major forehead angiosomes lined by the smaller calibre “choke” vessels. Conclusions: Periorbital Basal cell carcinoma resection may leave great defect to the underlying tissue. The need to provide adequate support to this structure requires complex techniques with minimum two flaps. In our case, we performed a split lateral forehead flap with a good functional and cosmetic outcome.
Klebsiella Pneumoniae Necrotizing Fascitis of The Lower Extremity in A 7-Month-Old Male: A Case Report and Literature Review
Authors: Zakanito Marelno , Saputro Iswinarno
Published: August 2021

Introduction: Klebsiella pneumoniae necrotizing fasciitis is an uncommon soft tissue infection characterized by rapidly progressing necrosis involving the skin, subcutaneous tissue, and fascia. This condition may result in gross morbidity and mortality if not treated in its early stages. In fact, the mortality rate of this condition is high, ranging from 25 to 35%. We present a case of 7-month-old male with K. pneumoniae necrotizing fasciitis of the lower extremity. Materials and Methods: A 7-month-old male presented with large areas over both left and right inferior side of the lower limbs to the emergency department of Dr. Soetomo Academic Medical Center Hospital, Surabaya, Indonesia. Physical examination revealed elevated heart rate of 136 times per minute and increased body temperature of 38oC. The large areas on both lower limbs were darkened, sloughed off, and very tender to palpation. A small area over the right hand was erythematous and sloughed off. Laboratory evaluation demonstrated decreased hemoglobin of 6.2 g/dL and elevated leukocyte of 28,850 g/dL. Blood cultures demonstrated that K. pneumoniae was present. Discussion: NF is usually hard to diagnose during the initial period. The findings of NF can overlap with other soft tissue infections including cellulitis, abscess or even compartment syndrome. However, pain out of proportion to the degree of skin involvement and signs of systemic shock should alert the clinical to the possibility of NF. The clinical manifestations of NF start around a week after the initiating event, with induration and edema, followed by 24 to 48 hours later by erythema or purple discoloration and increasing local fever In the next 48 to 72 hours, the skin turns smooth, bright, and serous, or hemorrhagic blisters develop. If unproperly treated, necrosis develops, and by the fifth or sixth day, the lesion turns black with a necrotic crust. Conclusions: K. pneumoniae necrotizing fasciitis is a rare but lifethreatening disease. A high index of suspicion is required for early diagnosis and treatment of this condition
Severe Constricted Head – An Extreme Form Of Crouzon Syndrome Posing Challenging Fronto-Orbital Advancement : Case Reports
Authors: Lupitasari Ciptomurti , Zarasade Lobredia , Hutagalung Magda
Published: August 2021

Background : Constricted head or cloverleaf deformity in Crouzon syndrome is a severe form of the syndrome involving trilobed coronal and lambdoid synostosis. Crouzon syndrome with acanthosis nigricans is distinct from the classic Crouzon syndrome, characterized by thick and dark skin in body folds. The major problems resulting from constricted head are related to craniostenosis, orbitostenosis developing from abnormalities of the skull base associated with progressive rise in intracranial and intraorbital pressures which could progress to hydrocephalus and cerebellar herniation. Case: Two cases with severe Crouzon syndrome were reported. The first was a five month old girl associated with acanthosis nigricans and the other was a sixteen month old boy, both whose phenotypic expressions were at the extreme severe end of the disease spectrum. On examination there was serious corneal exposure, visual loss, severely narrow head, midface hypoplasia, and beaked nose. CT scan showed typical cloverleaf skull, expanded middle cranial fossa, foreshortened anterior and posterior fossae and honeycomb appearance in the occiput involving pansutural synostosis and extensive copper beaten deformity from the high intracranial pressure . Both were complicated with hydrocephalus requiring ventriculoperitoneal shunt. This required an arduous effort in releasing the brain from the multiply punctured calvaria, avoiding excessive dural tear and bleeding and ultimately preserving the brain. Excessive bleeding was also caused by the raised ICP. Both patients are planned to undergo occipital expansion three months later. Conclusion: Severely constricted head in Crouzon syndrome is an extreme manifestation and late stage of the syndrome which not only will result in irreversible complication but will require meticulous surgical technique.
Pengaruh urea dalam media maturasi in vitro terhadap tingkat maturasi oosit sapi
Authors: Kurniawati Sepvian Dewi , Sarudji Suryanie , Widjiati Widjiati
Published: August 2021

This study was aimed to determine the effect of urea in maturation medium on in vitro oocyte maturation rate. The medium used was TCM-199 added with Hepes, NaHCO3, Kanamycin 0.15 IU/mL, PMSG, 0.15 IU/mL hCG, and 10% FBS. Cumulus oocyte complexes (COCs) of cows derived from follicle aspiration were divided into three groups. In control group (P0), the COCs were matured in vitro in a maturation medium without urea addition, meanwhile in the P1 and P2 groups, the medium was added with urea 20 and 40 mg/dL, respectively. Each petri dish contained three drops of maturation medium (300 µl/drops) according to the groups. Microdrops were coated with mineral oil and then incubated in a 5% CO2 incubator, at 39 ˚C with maximum humidity. Aceto-orcein staining was conducted to evaluate the maturation of oocytes based on the achievement of metaphase II phase that is indicated by the presence of metaphase plate and/or first polar body. The result showed that the oocyte maturation rates of P0, P1, and P2 were 51.25, 52.43 (p >0.05), and 46.88 % (p <0.05) respectively. It could be concluded that the presence of urea at 40 mg/dL in maturation medium reduced the percentage of bovine oocyte maturation in vitro.
Serum Progesterone profile of pregnant Ettawa crossbred does at day-0, -21, -42, -63 and -84
Authors: Bellani Ayu Aprodhita Cintya , Ismudiono Ismudiono , Hariadi Mas'ud , Lokapirnasari Widya Paramita
Published: August 2021

This study aimed to determine the progesterone concentrations of Ettawa crossbred does at day-0, -21, -42, -63, and -84 after mating. Five Ettawa crossbred does were injected with PGF2α twice with an interval of 11 days for estrous synchronization followed by natural mating on day-3 after the second PGF2α injection. Blood was collected through the jugular vein for the measurement of serum progesterone concentrations using ELISA, whereas pregnancy was diagnosed at 90 days after mating by abdominal palpation. The results showed that all does were on estrus onthethird day after the second PGF2α, three of them diagnosed to be pregnant following mating. The progesterone concentration at day-0 was 1.52 ± 0.33 ng/mL, increased (p <0.05) to 7.08 ± 1.02 and 5.50 ± 2.82 ng/mL at day-21 and day-42, and increased (p <0.05) again to 12.01 ± 5.30 and 12.04 ± 0.30 ng/mL at day 63 and day 84, respectively. There was no significant difference in progesterone concentrations between day 21 and day 42 and between day 63 and day 84. It could be concluded that there was a biphasic increase of progesterone concentrations of the pregnant Ettawa crossbred does, i.e. from day-0 to day-21/day-42 and from day-21/day-42 to day-63/day-84.
The Application of Morning Routine for Patients with Critical Illness in Intensive Care Units: A Case Report
Authors: Massie Juliana G.E.P , Waluyo Agung , Putra Kharisma Adytama
Published: August 2021

Respiratory failure is still the main cause of morbidity and mortality at the Intensive Care Unit. One of the abnormalities in the respiratory system that can cause respiratory failure is Acute Respiratory Distress Syndrome (ARDS). This condition is a respiratory emergency characterized by a progressive decrease in oxygen after a serious illness or injury. Critical illness and treatment in the Intensive Care Unit are a less pleasant experience for patients and affect the patients’ psychologies. The unstable psychical conditions of the patients during the treatments also influence the physical condition of the patients and it affected to the length of the stay, the risk for complications, and nosocomial infections. Patients’ ability to be adapted to the intensive care environment is one of the keys to the success of the nursing care for the critical cases. The purpose of this study is to describe the comprehensive and holistic nursing care management in ARDS cases at the Intensive Care Unit. One of the focuses of the nursing interventions, in this study, is the environmental and intensive care atmosphere modifications of the intensive care unit called the morning routine.
Identification of 1, 2, 4-Triazine and Its Derivatives against Lanosterol 14 - Demethylase (CYP51) Property of Candida Albicans: Influence on the Development of New Antifungal Therapeutic Strategies
Authors: Verma Abhishek Kumar , Majid Aarfah , Hossain Md. Shahadat , Ahmed Sk. Faisal , Ashid Mohammad , Bhojiya Ali Asger , Ameta Satish , Upadhyay Sudhir K. , Srivastava Abhishek K. , Vishwakarma Naveen Kumar , Yadav Vijay Kumar , Teli Pankaj Kumar , Harina Harina , Alam Mudassir
Published: August 2021

This research aims to find out whether the synthetic 1, 2, 4-triazine and its derivatives have antifungal effects and can protect humans from infection with Candida albicans. Molecular docking and molecular dynamic simulation are widely used in modern drug design to target a We are interested in using molecular docking and molecular dynamics modelling to investigate the interaction between the derivatives of 1, 2, 4-triazine and the resulting lanosterol 14 - demethylase (CYP51) of Candida albicans The inhibition of Candida albicans CYP51 is the main goal of our research. The 1, 2, 4-triazine and its derivatives have been docked to the CYP51 enzyme, which is involved in Candida albicans Multidrug Drug Resistance (MDR). Autodock tools were used to identifying the binding affinities of molecules against the target proteins. Compared to conventional fluconazole, the molecular docking results indicated that each drug has a high binding affinity for CYP51 proteins and forms unbound interactions and hydrogen bonds with their active residues and surrounding allosteric residues. The docking contacts were made using a 10 ns MD simulation with nine molecules. RMSD, RMSF, hydrogen bonds, and the Rg all confirm these conclusions. In addition, these compounds were expected to have a favorable pharmacological profile and low toxicity. The compounds are being offered as scaffolds for the development of new antifungal drugs and as candidates for future in vitro testing.
Developing an online learning community through an open reflective assessment
Authors: Owen John , Wasiuk Catherine , Nokes Ailsa , Roderick Sian
Published: August 2021

The concepts of learning communities, open educational practices and co-created teaching and learning are topics of current debate, particularly since the switch to online learning in 2020/21 because of the COVID-19 pandemic. This case study uses student feedback to evaluate a new assessment method introduced within an online distance learning Master of Public Health programme. The assessment required students to blog about their motivations for studying public health, submitting their reflections to an open online platform, resulting in the co-creation of a shared, open-learning resource for current and future students. The assessment design was informed by the benefits of open educational practices and co-created teaching and learning, with the overall aim of developing an online learning community that will continue to grow and develop beyond the initial assessment and cohort. Feedback suggests that the open, reflective nature of the assessment had a positive impact on the student learning experience and contributed towards a sense of learning community through enhanced social cohesion within the group.
Staff and student perspectives of online teaching and learning; implications for belonging and engagement at university – a qualitative exploration
Authors: Abu Lija , Chipfuwamiti Craig , Costea Adrian-Mihai , Kelly Alison Faith , Major Krisztina , Mulrooney Hilda Mary
Published: August 2021

A sense of belonging within higher education (HE) enhances educational engagement and attainment. The rapid shift to online provision has implications for reducing students’ sense of belonging at university. We have previously shown that students consider belonging in HE to be important and that their personal sense of belonging was high. We also found that sense of belonging had elements of people and place: relationships with peers and staff were influential and the physical campus facilitated social relationships. In the first lockdown, we showed that sense of belonging in both staff and students at our large widening-participation London university was reduced. In this paper, we report on a continuing project to explore the impact of sustained provision of learning online, focusing on qualitative interviews carried out with forty-three students and twenty-three staff. Both groups identified advantages and disadvantages of online provision. Advantages included flexibility and accessibility, with savings – financial and time – owing to reduced commuting. However, both groups identified a negative impact on social relationships, student motivation and engagement. Future development of blended learning should be planned, supported and structured to optimise the benefits.
Engaging students in online learning: technology-integrated distance learning for Chinese students at partner institutions in China
Authors: Gao Xiaowen
Published: August 2021

To mitigate the problems of lack of preparedness and lack of a sense of learning community associated with online learning, this case study illustrates how a range of technologies including online platforms and educational tools may be integrated to assist purposeful engagement with learners for active learning to ensue. This case is based on an undergraduate module delivered virtually to three TNE partner institutions in China. Zoom, Mentimeter and WeChat were adopted to help with cognitive and affective engagement by the students. While this design is focused on online delivery, there is also an important implication for classroom-based teaching in achieving purposeful engagement with students.
The climate emergency in higher education: working together to meet the challenge of student activism
Authors: Cross Iain David , Congreve Alina
Published: August 2021

This conference reflection explores the themes raised by participants in the authors’ interactive workshop at the SHIFT 2021 conference. The workshop focused on how universities are responding to the climate emergency through innovative teaching practices.
Reimagining the role of technology in higher education: the new normal and learners’ likes
Authors: Greve Katharina , Tan Aaron
Published: August 2021

The COVID-19 pandemic forced universities to look at teaching provision. As a result, new technologies, an increasing usage of existing online platforms and alternative ways to engage with learners in the classroom, have together become ‘the new normal’. This research aims to answer the questions: how do higher education learners perceive the new role of technology in the classroom? Is technology overload counteracting the potential benefits that blended delivery can offer? In-depth semi-structured interviews with eight students from two seminar groups reveal their positive perception of and continuous interest in the use of technology in the physical and virtual classroom. The study provides examples and recommendations, enabling the effective deployment of technology focusing on three areas: the learner, the facilitator and the technology. Finally, this study makes important contributions to constructivism in the context of technology usage and current and post-pandemic pedagogic practice.
The Association between Serum Lactate Dehydrogenase Level and In-hospital Death due to Pulmonary Embolism
Authors: Ghaffari Samad , Hajizadeh Reza , Mohammadi Tooba , Kavandi Hadis , Mohammadi Kamran , Mohebalizadeh Mehdi , Sedokani Amin
Published: August 2021

Background: Few studies are evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed the possible power of serum LDH levels to predict in-hospital mortality.Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included.Results: The mean age of patients was 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however, this association was not significant.Conclusion: LDH can be a good prognostic marker for predicting in-hospital death in patients with pulmonary embolism.
Quality of Life After Sialendoscopy: Prospective Non-Randomized Study
Authors: de Melo Giulianno Molina , Neves Murilo Catafesta das , Rosano Marcello , Vanni Christiana Maria Ribeiro Salles , Abrahao Marcio , Cervantes Onivaldo
Published: August 2021

Background: The symptomatic (swelling and pain) salivary gland obstructions are caused by sialolithiasis and salivary duct stenosis, negatively affecting quality of life (QOL), with almost all candidates for clinical measures and minimally invasive sialendoscopy. The impact of sialendoscopy treatment on the QOL has been little addressed nowadays. The objective is to prospectively evaluate the impact of sialendoscopy on the quality of life of patients undergoing sialendoscopy due to benign salivary obstructive diseases, measured through QOL questionnaires of xerostomia degree, the oral health impact profile and post sialendoscopy satisfaction questionnaires. Result: 37 sialendoscopies were included, most young female: 64.5% sialolithiasis, 35.4% post-radioiodine; 4.5 times/week painful swelling; 23.5 months symptom duration; pre- and post-sialendoscopy VAS values: 7.42 to 1.29 (p<0.001); 86.5% and 89.2% were subjected to sialendoscopy alone and endoscopic dilatation respectively; 80.6% reported improved symptoms after sialendoscopy in the sialolithiasis clinic (p<0.001). The physical pain and psychological discomfort domain scores were mostly impacted where sialendoscopy provided relief and improvement (p<0.001). We found a positive correlation between sialendoscopy and obstructive stone disease (p<0.001) and no correlation in sialendoscopy satisfaction in xerostomia patients (p=0.009).Conclusions: We found improved symptoms with overall good satisfaction after sialendoscopy correlated with stones; and a negative correlation between xerostomia. Our findings support the evident indication of sialendoscopy for obstructive sialolithiasis with a positive impact on QOL and relative indication to xerostomia that barely improved QOL satisfaction.Trial Registration: WHO Universal Trial Number (UTN): U1111-1247-7028 Brazilian Clinical Trials Registry (ReBeC): RBR-6p8zfs
Performance Evaluation of Geological Disaster Relief Operations in China using SBM-DEA Methodology
Authors: bai pengfei , La ruifang , Duan Qianqian
Published: August 2021

Geological disasters have caused enormous damage to human beings and the economy in China. Chinese government pay great effort on geological disaster relief. Usually, the efficiency of the disaster rescue is the first priority to be considered. Takeing the historical analysis of China's geological disaster rescue as the main line ,in this paper, we developed a slacks-based measure data envelopment analysis (SBM-DEA) model to evaluate the performance of 18 geological disasters relief during 2015–2019 in China, which are used to examine the performance of the geological disasters rescue activities. The results show that though the capabilities of geo-disaster relief is continuous improvement from 2015 to 2019, China’s geological disasters rescue system is still at the primary stage. Especially, the efficiency of landslide rescue operation is pretty low. We analysis the factors influencing the efficiency and provide several suggestions for capacity improvement of geo-disasters rescue.
Does the Presence of Renal Vascular Variation in the Renal Allograft Determine the Outcome of Renal Transplantation? Experience from the National Kidney Transplantation Center, Ethiopia
Authors: Wondmagegn Habtamu , Gebremickael Abinet , Bekele Mahteme , George Mala , Fikadu Teshale , Hailu Tadiwos , Ayele Tsegazeab
Published: August 2021

Background: Renal transplantation is the treatment of choice for people who suffer from end stage renal disease. Renal vascular anatomy is known for presenting a wide range of variations. Kidneys with variant renal vascular anatomy when used as a graft appear to be a potential risk factor that could impair the outcome of kidney transplantation. Information on renal vascular variations and its implication in the surgical outcome of renal transplantation has not been well studied. Hence, the present study was aimed to evaluate the outcomes of transplantation of renal allografts with variant renal vasculature as compared to allografts without renal vascular variation in the national kidney transplantation center of Ethiopia.Methods: A health institution based cross-sectional study was conducted. A retrospective review of the medical records of kidney recipients was performed. A total of 120 renal transplant recipient’s medical records were evaluated. Chi-square test and Independent t test was used to compare the surgical outcomes of renal transplantation. Graft survival was expressed using Kaplan-Meier curves, and was compared using the log-rank test. P values less than 0.05 was considered as statistically significant. Result: Evaluation of the renal transplant outcomes did not have shown a significant difference in the postoperative complication rate, rate of delayed graft function (DGF), creatinine clearance levels at 1 , 6, or 12 months postoperatively, and 1-year graft survival among recipients of allografts with and without renal vascular variations. However, operation time and the length of hospital stay were significantly longer among recipients of allografts with variant vasculature.Conclusion: No significant difference was noted in the outcomes of transplantation of renal allografts with and without vascular variations. Hence, renal allografts with vascular variations are safe to be recruited for transplantation as to this study.
Joint Reconstruction Framework of Compressed Sensing and Nonlinear Parallel Imaging for Dynamic Cardiac Magnetic Resonance Imaging
Authors: Hu Zhanqi , Zhao Cailei , Zhao Xia , Kong Lingyu , Yang Jun , Wang Xiaoyan , Liao Jianxiang , Zhou Yihang
Published: August 2021

Compressed Sensing (CS) and parallel imaging are two promising techniques that accelerate the MRI acquisition process. Combining these two techniques is of great interest due to the complementary information used in each. In this study, we propose a new reconstruction framework for dynamic cardiac imaging that takes advantage of both CS-based dynamic imaging and one nonlinear parallel imaging technique. The method decouples the reconstruction process into two sequential steps: use CS to reconstruct a series of aliased dynamic images from the highly undersampled k-space data; use nonlinear GRAPPA method, one nonlinear technique of parallel imaging, to reconstruct the original dynamic images from the k-space data that has been reconstructed by CS. The sampling scheme of the proposed method is designed to simultaneously satisfy the incoherent undersampling requirement for CS and the structured undersampling requirement for nonlinear parallel imaging. Four in vivo experiments of dynamic cardiac cine MRI were carried out with retrospective undersampling to evaluate the performance of the proposed method. Experiments show the proposed method of dynamic cardiac cine MRI is superior at reducing aliasing artifacts and preserving the spatial details and temporal variations, when compared with k-t FOCUSS and k-t FOCUSS with sensitivity encoding, using the same numbers of measurements. The proposed joint reconstruction framework effectively combines the CS method and one nonlinear technique of parallel imaging, and improves the image quality of dynamic cardiac cine MRI reconstruction when comparing to the state-of-the-art methods.
Functional Connectivity Density Alterations in Children with Strabismus and Amblyopia based on Resting-state Functional Magnetic Resonance Imaging (fMRI)
Authors: Shi Yi-Dan , Ge Qian-Min , Lin Qi , Liang Rong-Bin , Li Qiu-Yu , Shi Wen-Qing , Li Biao , Shao Yi
Published: August 2021

Purpose: To investigate functional connectivity density (FCD) values of brain areas in children with strabismus and amblyopia (SA) by resting-state functional magnetic resonance imaging (rs-fMRI).Methods: This study recruited 26 children (14 male, 12 female) with SA and 26 healthy children (14 male, 12 female) as healthy controls. Both groups matched in age, gender, educational level and socioeconomic background. All participants underwent fMRI scanning while resting. Visual function of participants was also evaluated by an ophthalmic examination; rs-fMRI data was then used to determine global and short-range FCD. Receiver operating characteristic curves were constructed to investigate whether there was a significant difference between children with SA and healthy controls. This experiment has passed the ethical approval and obtained the logic number cdyfy201511.Results: Global FCD values of children with SA were found to be remarkably decreased in the right cerebellum, left lenticular nucleus, putamen, and right superior frontal gyrus as compared with healthy controls; global FCD values of children with SA were increased in the right angular gyrus, left middle cingulate gyrus, left angular gyrus, right superior parietal gyrus, and right middle frontal gyrus. In children with SA, short-range FCD values were found to be remarkably decreased in regions of the middle right temporal pole, right cerebellum, left lenticular nucleus, putamen, left hippocampus, right hippocampus, left thalamus, left cerebellum; values were increased in the right superior parietal gyrus as compared with healthy controls.Conclusion: We noted abnormal neural connectivity in some brain areas of children with SA; the detailing of such connectivity aberrations is helpful in exploring the pathophysiology of SA and providing useful information for future clinical management.
Reusing of Real Textile Wastewater After Treatment by Gamma Irradiation: Implications on the Growth of Capsicum Frutescens Plant
Authors: AHSAN MD ARIFUL , Rahman M. Safiur , Bhuiyan Md. Abdul Quaiyum , Rahaman Md. Saifur , Rahman Mir Tamzid , Khan Mubarak Ahmad
Published: August 2021

This investigation concentrates on the possibility of using gamma radiation for the decomposition of textile wastewater and reuse as irrigation water. The real wastewater sample was irradiated at four different radiation doses of 3, 5, 8, and 10 kGy. After irradiation at 8–10 KGy, physicochemical parameters, i.e., pH, turbidity, EC, total suspended solids (TSS), total dissolved solids (TDS), biological oxygen demand (BOD5), and chemical oxygen demand (COD) have decreased sharply and approached to the expected value. At maximum 10 KGy radiation dose, 59.0 % BOD5 and 71.6 % COD removal have been achieved, accelerating the enhancement in biodegradability index (BOD5/COD, 0.43). Ammonium and total nitrogen have improved up to 87.0 % and 94.5 % after irradiation at 10 KGy doses. These treated textile wastewater samples were reused to grow Capsicum frutescens plants to inspect the fertility responses. When Capsicum plants were nourished by textile wastewater irradiated at 8–10 kGy, the dry masses of the fruits, moisture content, root length, average plant height, average number of leaves, and total number of fruits were increased in comparison to those plants nourished by simply water and raw wastewater. The elemental analysis confirmed that the heavy metals concentration in Capsicum fruits decreased gradually with higher radiation doses. Helpful macro and micronutrients for plant production such as Na, K, and Mg were raised at a sufficient level of 47.7 %, 23.5 %, and 63.8 % for 10 KGy, whereas the highest 50.0 % increase in Ca concentration was found for 8 KGy fruit samples.
Universal non-Hermitian skin effect in two and higher dimensions
Authors: Zhang Kai , Yang Zhensen , Fang Chen
Published: August 2021

Skin effect, experimentally discovered in one dimension, describes the physical phenomenon that on an open chain, an extensive number of eigenstates of a non-Hermitian hamiltonian are localized at the end(s) of the chain. Here in two and higher dimensions, we establish a theorem that the skin effect exists, if and only if periodic-boundary spectrum of the hamiltonian covers a finite area on the complex plane. This theorem establishes the universality of the effect, because the above condition is satisfied in almost every generic non-Hermitian hamiltonian, and, unlike in one dimension, is compatible with all spatial symmetries. We propose two new types of skin effect in two and higher dimensions: the corner-skin effect where all eigenstates are localized at one corner of the system, and the geometry-dependent-skin effect where skin modes disappear for systems of a particular shape, but appear on generic polygons. An immediate corollary of our theorem is that any non-Hermitian system having exceptional points (lines) in two (three) dimensions exhibits skin effect, making this phenomenon accessible to experiments in photonic crystals, Weyl semimetals, and Kondo insulators.
Mechanism for reconfigurable logic in disordered dopant networks
Authors: Tertilt Henri , Bakker Jesse , Becker Marlon , de Wilde Bram , Klanberg Indrek , Geurts Bernard , Wiel Wilfred van der , Heuer Andreas , Bobbert Peter
Published: August 2021

We present an atomic-scale mechanism based on variable-range hopping of interacting charges enabling reconfigurable logic and nonlinear classification tasks in dopant network processing units in silicon. Kinetic Monte Carlo simulations of the hopping process show temperature-dependent current-voltage characteristics, artificial evolution of basic Boolean logic gates, and fitness-dependent gate abundances in striking agreement with experiment. The simulations provide unique insights in the local electrostatic potential and current flow in the dopant network, showing subtle changes induced by control voltages that set the conditions for the logic operation. These insights will be crucial in the systematic further development of this burgeoning technology for unconventional computing. The establishment of the principles underlying the logic functionality of these devices encourages the exploration and utilization of the same principles in other materials and device geometries.
Accurate Five-category Classification for Colorectal Cancer Using Gut Microbiome 16S rRNA Sequencing
Authors: Zhang Liying , Zhu Jiaqi , Ding Qiutao , Huang Yanqi , Zhang Hongbo , Ma Shiqing , Han Mingya , Zheng Shu , Zheng Weixian , Liu Jun
Published: August 2021

The association between the gut microbiome and the five stages of colorectal cancer (CRC) (healthy, polyposis, nonadvanced adenoma, advanced adenoma, and cancer) remains unclear. We performed 16S rRNA sequencing of the V3-V4 amplicon from 999 samples from subjects at various stages of CRC development and constructed an accurate predictive random forest model for CRC development. In the testing set, our five-category CRC prediction classifier had accuracies of 0.84 and 0.74 using the relative operational taxonomic unit (OTU) abundances and relative genus abundances, respectively. Specifically, the OTU-based classifier had a sensitivity of 0.97 and specificity of 0.97 for CRC samples, and the genus-based classifier had a sensitivity of 0.97 and specificity of 0.95 for CRC samples. Meanwhile, the gut microbiota was found to differ at all stages of CRC development. The differential abundances of closely related bacteria were used to accurately classify the five stages of CRC development. Additionally, both unannotated and annotated OTUs played important roles in classifier modelling. Our work not only provides valuable 16S rRNA sequencing data from patients and healthy individuals on a large scale but also identifies reproducible gut microbiome biomarkers for CRC staging and highlights their potential applications as noninvasive microbiome biomarkers for diagnosis and as predictive CRC screening tests.
Phytochemical Characterization, Pharmacological Properties And Toxicity of Amazonian Fruit Cubiu (Solanum Sessiliflorum Dunal)
Authors: Dalenogare Jéssica Franco , Somacal Sabrina , Machado Vanessa Schopf , Montagner Greice Franciele Feyh dos Santos , Verdi Camila Marina , Duarte Marta Maria Medeiros Frescura , Emanuelli Tatiana , Santos Roberto Christ Vianna , Sagrillo Michele Rorato , Bauermann Liliane de Freitas
Published: August 2021

The cubiu (Solanum sessiliflorum) is a tropical fruit native to the Amazon region and widely used in medicine and cosmetics, despite the lack of research regarding the actual safety and effectiveness of its use for these purposes. This study aimed to evaluated the phytochemical characterization, pharmacological properties (skin wound healing, antimicrobial and anti-inflammatory properties), and toxicity of cubiu extract. The cubiu antimicrobial capacity was determined against strains of Aeromonas caviae, Pseudomonas aeruginosa, and Sphingomonas paucimobilis. Additionally, cubiu toxicity (hemolysis, coagulation, cell viability, and genotoxicity tests), antioxidant activity (reactive oxygen species total levels), scratch assay (in vitro skin wound healing), and anti-inflammatory activity against phytohemagglutinin and in the scratch assay (Interleukin 1, interleukin 6, interleukin 10, tumor necrosis factor-alpha, and interferon-gamma levels), were evaluated. Human fibroblast cells were used to evaluate skin wound healing, and human peripheral blood mononuclear cells were used for the other assessments. Our findings showed that the cubiu extract is rich in phenolic compounds, the major compound being 5-caffeoylquinic acid. In addition, was effective against the three bacterial strains tested and inhibited and destroyed the biofilm formed by Pseudomonas aeruginosa. The cubiu extract also was no toxicity, maintained the hemocompatibility parameters in the biological range, improved cell viability, decreased reactive oxygen species total levels and pro-inflammatory cytokine levels, increased anti-inflammatory cytokine levels, and accelerated the wound healing process. In conclusion, this is the first research to prove that cubiu is an important compound for use in the skin diseases, promoting skin wound healing, antimicrobial and anti-inflammatory activities.
SSR Marker-Based Genetic Resource Assessment of The Rainbow Clam Moerella Iridescens Along The Coasts of China: Implications for Strategy of Conservation Management
Authors: Li Xiaoying , Gao Shan , Zhao Manman , Dong Zhiguo
Published: August 2021

This study aims to determine the genetic structure and diversity of rainbow clam Moerella iridescens in different sea areas of China. Seventeen pairs of microsatellite primers (SSR) were used to amplify the SSRs of rainbow clam in Lianyungang of Haizhou Bay, Chongming of Shanghai, Ningde in Fujian, Cixi and Wenzhou in Zhejiang. A total of 1146 alleles were detected in 310 individuals from the 17 SSR loci. The average observed heterozygosity of six populations was 0.4381–0.6139, the average expected heterozygosity was 0.5897–0.7325, and the average Shannon diversity index was 1.2655–1.7998. The clams exhibited rich genetic diversity and the FST of the genetic differentiation index of the six populations was 0.0470, indicating low genetic differentiation amongst the populations. The results indictated that rainbow clam along China coasts exhibited high diversity and low population differentiation.
Improving Nurses' Performance in Safe Handling of Antineoplastic Agents: a Quasi-experimental Study
Authors: Nouri Arezoo , Seyyedjavadi Mehri , Iranijam Effat , Aghamohammadi Masoumeh
Published: August 2021

Background: The safe, principled, and standard handling of anticancer drugs can reduce the effects of occupational exposure and promote safe behaviors in nurses. Thus, the present study aimed to determine the effects of standard guidelines education on the safe handling of anti-neoplasm drugs among oncology nurses in Ardabil, Iran.Methods: The quasi-experimental study with one-group pretest-posttest design was performed among 32 nurses employed in the oncology wards of two educational hospitals in Ardabil city, during 2020. All of the nurses in the wards who met the inclusion criteria participated in the study. The data were collected by using a demographic information form and nurses' knowledge assessment questionnaire regarding the standard guidelines for working with antineoplastic drugs, and a standard checklist for examining their performance in this regard. Then, they were analyzed through descriptive (mean and standard deviation) and inferential statistics (t-test and Pearson's correlation coefficient) in SPSS 22.Results: The mean and standard deviation of the knowledge and performance scores of the oncology nurses was respectively determined 59.56±6.41 and 18.96±2.54, which changed to 66±4.82 and 32.03±2.45 three months after training. The results of t-test represented a statistically significant difference between the level of knowledge and performance before and after the intervention (P=0.001).Conclusions: Based on the results, the standard guidelines education improved the nurses' knowledge and performance on the safe handling of anticancer drugs in the chemotherapy wards. Therefore, it is suggested to pay attention to the promotion of the oncology nurses' awareness in the planning and policy-making of healthcare centers.