bluuebunny/crossref_metadata_2025 huggingface dataset:
Family Functionality and Its Relationship with Depression and Anxiety in Recovered COVID-19 Patients in a Primary Care Center of Tijuana, Mexico
Authors:   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, MA Salazar-Perfecto , F Ruiz-Gonzalez ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, SS Sanchez-Sanchez ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, JN Lopez-Hernandez ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, MF Ramonetti-Armenta ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, CA Alvarez-Franco ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico
Published: January 2023

Background: In the coronavirus infection, it is important to consider the neuropsychiatric implications; preliminary studies of this new pandemic suggest that patients with COVID-19 may experience depression and anxiety. In that way, family functionality is a determining factor in health preservation of patients with mental disorders and COVID-19. Objective: To determine the family functionality and its relationship with depression and anxiety in recovered COVID-19 patients in a primary care center of Tijuana, Mexico. Methods: A review of clinical records of patients with COVID-19 was carried out at the Family Medicine Unit #27 in Tijuana, Mexico, from July to December 2020. A descriptive cross-sectional study was implemented to know the frequency of depression, anxiety and family functionality in recovered COVID-19 patients. Symptoms of depression were assessed with the Trait Depression Inventory – IDERE. Anxiety was measurement with Spielberger's Trait Anxiety Inventory. Family functionality was determined with family APGAR. Quantitative variables were described as median and interquartile range (IQR), and qualitative variables were expressed as frequency and percentage. The assumption of normality was made by the Kolmogorov-Smirnov test. The Chisquared test was used to analyze differences in categorical variables, and the Odds ratio was used to calculate risk. Results: 560 patients were studied, of which 179 met the selection criteria and 151 entered the study. 54.31% of patients have moderate to severe symptoms of depression, 80.13% moderate to severe symptoms of anxiety and 18.54% alteration in family functionality. Conclusions: COVID-19 is a public health problem that affects multiple dimensions with significant repercussions. It is necessary to apply an early biopsychosocial approach to treat these alterations and avoid their chronicity in order to improve quality life of these patients.
The Use of ROTEM in Liver Transplant Surgeries: A Luxurious Option or a Necessity?!
Authors:   Hematological Pathology, Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada, AL Muntadhar , MD Moosawi ,   Hematological Pathology, Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada
Published: January 2023

Blood management in liver transplant surgeries can be challenging. In this article I will address some of the strenuous challenges related to blood management in this patient population and discuss the use of rotational thromboelastometry (ROTEM) to mitigate these challenges. It is well known that patients with liver disease have a rebalanced hemostasis due to the impaired synthesis of both the coagulation factors and pro-coagulant factors. Interestingly, some studies demonstrated an increased endogenous thrombin potential (ETP) in patients with liver cirrhosis [1]. Hence, it is now well known that this group of patients requires special attention when it comes to blood management.
Laboratory Diagnosis and Classification of Von Willebrand Disease: A Review
Authors:   Haemostasis Unit, Department of Haematology, Antwerp University Hospital, Edegem, Belgium, I Vangenechten , A Gadisseur ,   Haemostasis Unit, Department of Haematology, Antwerp University Hospital, Edegem, Belgium
Published: January 2023

Von Willebrand Disease (VWD), as the most common inherited bleeding disorder, is a widely misdiagnosed disease due to several diagnostic pitfalls. At the heart of this challenge lies the complexity and heterogeneity of VWF, significant (pre-) analytic issues, limited access to a comprehensive repertoire of laboratory assays, inter-individual variations, lack of expertise and complex interpretation of results. Next to a personal and family bleeding history, an array of clinical laboratory tests is required because no single test reflects both quantity and quality of VWF. The assays measure different VWF properties and may be affected by (pre-) analytic variables possibly leading to inaccurate interpretation. Therefore, a laboratory investigation and diagnosis according to a standard algorithm, and repetitive testing, are essential for accurate diagnosis which is illustrated in detail in this review.
Boosting CO2 Photoreduction by π-π-Induced Preassembly between a Cu(I) Photosensitizer and a Pyrene-Appended Co(II) Catalyst
Authors: Wang Jia-Wei , Li Zizi , Luo Zhi-Mei , Huang Yanjun , Ma Fan , Kupfer Stephan , Ouyang Gangfeng
Published: January 2023

The design of a highly efficient system for CO2 photoreduction fully based on earth-abundant elements presents a challenge, which may be overcome by installing suitable interactions between photosensitizer and catalyst to expedite the intermolecular electron transfer. Herein we have designed a pyrene-decorated Cu(I) complex with a rare dual-emission behavior, aiming at additional π-interaction with a pyrene-appended Co(II) catalyst for visible-light-driven CO2-to-CO conversion. The results of 1H NMR titration, time-resolved fluorescence/absorption spectroscopies, quantum chemical simulations and photocatalytic experiments clearly demonstrate that the dynamic π-π interaction between sensitizer and catalyst is highly advantageous in photocatalysis by accelerating the intermolecular electron transfer rate up to 6.9 × 105 s-1, thus achieving a notable apparent quantum yield of 19% at 425 nm with near-unity selectivity. While comparable to most earth-abundant molecular systems, this value is over three-times of the pyrene-free system (6.0%) and far surpassing the benchmarking Ru(II) tris(bipyridine) (0.3%) and Ir(III) tris(2-phenylpyridine) (1.4%) photosensitizers under parallel conditions.
CVD Process Design for 2-D Material Synthesis: Best Practices and Reporting Guidelines
Authors: Chatterjee Shahana , Abadie Thomas , Wang Meihui , Matar Omar , Ruoff Rodney
Published: January 2023

Though Chemical Vapor Deposition (CVD) is a versatile process that has been widely used for synthesizing graphene, hexagonal boron nitride (h BN) and other 2-D materials, the process is plagued by repeatability and reproducibility issues as the growth environment inside the reactor remains virtually unknown. The problem is compounded by the fact that experimental details currently reported in the literature are insufficient to ensure reproducibility, with process details typically reported only partially, and details about the reactor not included at all. In this paper, using the example of the CVD synthesis of graphene in a hot-wall tube reactor, and, with the help of the Computational Fluid Dynamics toolbox OpenFOAM, we have simulated this growth environment and studied its sensitivity to different reactor and process parameters. Based on our findings, we have devised a protocol for reporting CVD processes in literature so that they may be completely reproducible in the future.
A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, Kp,uu
Authors: Lawrenz Morgan , Svensson Mats , Kato Mitsunori , Dingley Karen , Chief Elk Jackson , Nie Zhe , Zou Yefen , Kaplan Zachary , Lagiakos H. Rachel , Igawa Hideyuki , Therrien Eric
Published: January 2023

The blood-brain barrier (BBB) plays a critical role in preventing harmful endogenous and exogenous substances from penetrating the brain. Optimal brain penetration of small molecule CNS drugs is characterized by a high unbound brain/plasma ratio (Kp,uu). While various medicinal chemistry strategies and in silico models have been reported to improve BBB penetration, none were developed to predict Kp,uu directly. We describe a physics-based computational approach, solvation free energy calculations (energy of solvation or E-sol), to predict Kp,uu. Prospective application of this method to internal CNS drug discovery programs highlighted the utility and accuracy of this new method, which showed a categorical accuracy of 79% and a R2 of 0.61 from a linear regression model.
Fragment-based approaches to identify RNA binders
Authors: Suresh Blessy M. , Taghavi Amirhossein , Childs-Disney Jessica L. , Disney Matthew D.
Published: January 2023

Although fragment-based drug discovery (FBDD) has been successfully implemented and well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the challenges associate with the selective targeting of RNA, efforts to integrate known methods of RNA binder discovery with fragment-based approaches has been fruitful, as a few bioactive ligands have been identified. Here, we review various fragment-based approaches implemented for RNA targets and provide insight into experimental design and outcomes, to guide future work in the area. Indeed, investigations surrounding the molecular recognition of RNA by fragments address rather important questions such as the limits of molecular weight that confers selective binding and the physicochemical properties favorable for RNA binding and bioactivity.
Anomalous gelation of self-assembling ethanol molecules
Authors: Sakai Takaaki , Kanega Ryoichi , Ohira Akihiro , Hosono Eiji , Asakura Daisuke , Yamaguchi Takuya , Ishiyama Tomohiro , Bagarinao Katherine , Ohara Koji , Ina Toshiaki , Kishimoto Haruo , Oishi Masatsugu
Published: January 2023

A low-molecular-weight gel is one that is organized by small molecules via noncovalent bonds, and some low-molecular-weight gels already being used in our daily lives. In general, the mechanism of formation of low-molecular-weight gels involves the gelation of solvents such as ethanol and water in the presence of low-molecular-weight gelators, which have larger molecular weights than the solvents. The gelator creates a supramolecular network via noncovalent bonds, and this network holds the solvent molecules, causing them to lose fluidity and thereby promoting gelation. That is, low-molecular-weight gels do not self-assemble and gelate solvent molecules themselves; the literature contains no reports of the self-assembly and gelation of extremely small solvent molecules such as ethanol and water. However, in this work, we found that ethanol molecules themselves form a large gel structure by self-assembling with few-nanometer-diameter oxide nanoparticles and water molecules. Our finding reveals an intriguing phenomenon where ethanol molecules support the main structure of a large gel structure through supramolecular assembly via hydrogen bonding. The key factor for the gelation of ethanol observed in this study is the presence of BaZrO3 nanoparticles, which are positively charged and homogeneously dispersed. When these nanoparticles and water were present, we observed the gelation of a substantial amount of ethanol, which would not normally occur. Our results overturn the common belief that extremely small molecules such as ethanol cannot function as a main bearer of gelatinization, and our discovery opens a path to the development of a novel self-assembly system that has not been previously reported. In addition, because the method proposed in the present work can potentially be used to prepare gels that incorporate other extremely small molecules having hydrogen bonds, we expect our findings to lead to the development of various novel materials with unique functions.
Holistic Prediction of Nucleophilicity and Electrophilicity Based on a Machine Learning Approach
Authors: Liu Yidi , Yang Qi , Cheng Junjie , Zhang Long , Luo Sanzhong , Cheng Jin-Pei
Published: January 2023

Nucleophilicity and electrophilicity dictate the reactivity of polar organic reactions. In the past decades, Mayr et al. established a quantitative scale for nucleophilicity (N) and electrophilicity (E), which proved to be useful tools for the rationalization of chemical reactivity. In this study, a holistic prediction model was developed through a machine-learning approach. rSPOC, an ensemble molecular representation with structural, physicochemical, and solvent features, was developed for this purpose. With 1115 nucleophiles, 285 electrophiles and 22 solvents, the dataset was currently the largest one for reactivity prediction. The rSPOC model trained with the Extra Trees algorithm showed high accuracy in predicting Mayr’s N and E parameters with R2 of 0.96 and 0.92, MAE of 0.99 and 1.47, respectively. Furthermore, the practical applications of the model, for instance, nucleophilicity prediction of NAD(P)H and a series of enamines showed potential in predicting molecules with unknown reactivity within seconds. An online prediction platform (http://isyn.luoszgroup.com/) was constructed based on the current model, which is available free to the scientific community.
EVALUATION AND GENETIC DIVERSITY ANALYSIS OF LOCAL MANGO GERMPLASM
Authors: Alam Md Sarowar , Samsuzzaman Md. , Mazed Miah Md Abdul , Akter Sumi Mirana , Habib Md Ahasan
Published: January 2023

The experiment was conducted during 2019-2021 at Regional Agricultural Research Station, Akbarpur, Moulvibazar, Bangladesh with twenty-three local mango genotypes to assess the performance and genetic divergence for the identification of suitable parents for the futute breeding program. . Wide variations were observed regarding the number of fruits/plant, fruit weight, percent of edible portion, and TSS of different germplasms. The highest number of fruit per plant (610) was observed in MIAkb001, highest individual fruit weight /plant (759.7g) was obtained from MIAkb015. The higher fruit yield was recorded from MIAkb001 (162.07kg). The percent of the edible portion was higher in MIAkb014 (65.71%) whereas maximum TSS (18%) was obtained from MIAkb007 andMIAkb015 respectively. The genetic divergence was assessed in 23 mango genotypes through multivariate analysis. The genotypes under this study were grouped into five clusters and the diversity was influenced by the morphological characters. The highest number (8) of genotypes were in cluster-I and the lowest (1) number of the genotype was in cluster-III. From the PCA we found, the number of fruits per plant (FNPP), fruits yield per plant (FYPP), and individual fruit weight were positive across the two axes, and these were the main traits for genetic divergence.
EVALUATION OF PATIENT ABSORBED DOSE OF CONVENTIONAL X-RAYS USING DIRECT METHOD IN SOME HOSPITALS IN PORT HARCOURT, NIGERIA
Authors: . Etim , Edem Akanimo , . Akpan , and Yawo Ita Okon , Joseph Okwet
Published: January 2023

In this work, entrance skin dose was used to evaluate patient absorption dose of conventional X-rays using a direct method in some hospitals in Port-Harcourt, Rivers State. The method was based on the guidelines established by the NBIRR protocols. Questionnaires were distributed to two (2) X-ray facilities in Port Harcourt, Rivers State with code names GHC and UPTH in order to obtain information about X-ray machines such as type, model, waveform, filtration, etc., and radiological parameters used during two common diagnostic procedures such as Kilo Peak Voltage (kVp) and Milli Ampere Times Seconds (mAs). The two types of X-ray exams considered were chest (PA) and abdomen (AP). The weight and height of each patient totaling one hundred (100) were measured and two TLD badges were used on each patient to record the patient’s dose while a TLD reader (Harshaw 6600) was used to read the chips and an oven (annealing machine) was also used to anneal the chips. Mean ESD (mGy) was estimated and compared with International Established Reference Values. It was found that the mean ESD (mGy) for chest (PA) was 1.40, which is higher than the standard values of 0.17, 0.40, and 0.30 for USA, IAEA, and NRP, respectively. While the mean ESD (mGy) for the abdomen (AP) was found to be 1.62, which was higher than the standard values of 0.56, 1.02, and 102 for the USA, IAEA, and NRP, respectively. Generally, it was observed that there was a wide variation in patient dose for the two different types of x-ray examinations, which could be attributed to several factors, such as the type of x-ray machine used, radiographic techniques.
CYTOMIXIS AND MEIOTIC ABNORMAL BEHAVIOR RELATED IN SOME SELECTED SPECIES OF THE GENUS Salvia L. (Lamiaceae) FROM IRAN
Authors: Alijanpoor Behnaz , Safaeishakib Masoumeh
Published: January 2023

In this research, the cytogenetic characteristics, phases of meiosis, abnormality during meiosis, variety of pollen grains, and cytomixis phenomenon have been studied. Populations of 10 species belonging to Salvia L. have been collected from different geographical regions of Iran. Cytomixis was recorded during meiosis I in three species of Salvia (S. nemorosa, S. staminea, S. verticellata) of the Lamiaceae family. Cytomixis and other associated meiotic abnormalities such as chromatin stickiness, clumping of metaphase -1, laggards, bridges, aberrations anaphase I, II, and micronuclei in the species reported into pollen sterility and some variable sizes. It can be said all of these are dependent on each other to create some abnormalities. Cytomixis and chromosome migration occurre in diploid and polyploid meiocytes.
STUDY OF CHRONOLOGICAL ORDER IN INTERSECTING PRINTED AND PEN STROKES WITH THE HELP OF CHROMATICITY DIAGRAM
Authors: Ghimire Bal Ram , Giri Roshan , Chimouriya Shanker Prasad
Published: January 2023

Writing cross stroke examination is one of the difficult and challenging problem in forensic document examination. In this work, we tried to find sequence of order in crossing printed and pen strokes. The study mainly deals with application of chromaticity diagram generated by Video Spectral Comparator (VSC)-6000. Chromaticity co-ordinates are generated from three different points of first, second and cross strokes. When two strokes cross each other, then surface on point of intersection corresponds to second stroke. So, we have started this work with the assumption that chromaticity co-ordinate (x,y) of the crossing stroke should be similar to that of second stroke. We perform our experiment in both homogeneous and heterogeneous crossing strokes. We repeat the same experiment five times by preparing different samples each time to establish more valid conclusion but we get positive and conclusive results only in the case of heterogeneous crossing strokes where printed stroke is above the pen strokes.
EVALUATION OF TOXIC ELEMENTS IN GROUNDWATER IN THE INDUSTRIES AREA OF NNEWI NORTH SOUTH-EASTERN NIGERIA
Authors: K.A Ifeanyichukwu , C.M. Okolo, , A. Odoh,
Published: January 2023

Due to the unregulated flow of industrial wastes into the environment, industrial pollution is a major environmental issue in South-eastern Nigeria. It became critical to examine the influence of industrial activity on groundwater quality for home use. Following conventional protocols, twenty-two groundwater water samples were obtained inside the study region. Atomic Absorption Spectroscopy, method was used to determine the chemical compositions of all the samples collected. Groundwater Quality index was employed to evaluate the laboratory result. Potential Toxic Element concentrations in Groundwater for Cr, Fe, Ni, As, Cd, Hg and Al ranged from (0.00 to 0.83ppm, 0.32 to 0.56ppm 0.10 to 0.38ppm, 0.00 to 0.32ppm, 0.00 to 0.01ppm, 0.13 to 0.35ppm, and 0.00 to 1.21ppm) respectively. The various guidelines for water quality and the index revealed that the groundwater was contaminated, basically from anthropogenic sources. It´s recommended that the groundwater should be treated before consumption.
ORGANOPHOSPHATE AND CARBAMATE PESTICIDES RESIDUE ANALYSIS IN VEGETABLES PRODUCED IN FAR-WEST NEPAL
Authors: Budha Janaki , Sapkota Prativa , Acharya Archana , Bhandari Rakshya , B. Singh Narendra , Dhakal Deependra
Published: January 2023

This is an experimental research study carried out at the laboratory of wholesale fruits and vegetable market, Attarya, Kailali, to analyze organophosphate and carbamate pesticide residue in vegetables grown and marketed in four different districts of far-west Nepal by Rapid Bioassay of Pesticide Residue. The main goal of this study is to determine the proportion of AChE inhibition in various vegetable commodities and to compare the pesticide residue. Seven different vegetables were collected purposively from four distinct areas in Nepal’s far west region. Each of the 28 vegetable samples was analyzed for both organophosphate and carbamate residues. The sample was extracted from each vegetable and examined through a spectrophotometer and the data are interpreted. The experiment’s findings suggest that the Beans from Kanchanpur had the highest OP (21.69 percent) while cucumber from Dadeldhura had the lowest (0.07 percent). The bitter gourd of Kailali had the greatest C (24.39 percent), while the bottle gourd of Doti had the lowest (0.49 percent). All 56 items examined in the Attariya market laboratory were found to have low pesticide residue, with less than 35%. However, the waiting period must be strictly adhered to.
SPATIAL MODELING OF AIR POLLUTANT CONCENTRATIONS USING GWR AND ANFIS MODELS IN TEHRAN CITY
Authors: Isazade Vahid , Qasimi Abdul Baser , Seraj Keyvan , Isazade Esmail
Published: January 2023

Today, air quality is a major subject in city regions that have affected human health, the environment, and the city ecosystem. Therefore, government officials, environmental organizations, health organizations, and city managers often need to model the concentration of air contaminants. This study aimed to compare geographically weighted regression (GWR) modeling and neural network (ANFIS) using Segno and Mamdani rules to spatially predict the concentration density of fNO2, CO, and SO2 pollutant indices. And PM 2.5 for the year 2021 in Tehran. The results of the statistical analysis of Sugeno and Mamdani rules revealed that the (RMSE) in evaluating the ANFIS model with the Mamdani method was 0.895 ppm, and with the Sugno method it was 1.004 ppm, whereas the RMSE in terms of Spatial weighted regression model was obtained on digital model with a height of (12.5 m) and a value of 692.0 ppm. The evaluation results showed that Mamdani and Sugno laws do not have the same and desirable accuracy. For Mamdani law, the RMSE level of PM 2.5 pollutant was (0.71 ppm) and according to Sugno law, this level was obtained for CO pollutant (0.81 ppm). While evaluating the geographically weighted regression model for the four air pollution indices the digital altitude model of (12.5 m) had similar results, which statistically for the digital altitude model of (12.5 m) obtained the RMSE for PM 2.5 (0.82 ppm). The findings of this study demonstrated that the weighted geographic regression model and the ANFI neural network have acceptable functionalities for spatial prediction of air pollutants.
Lineage tracing reveals fate bias and transcriptional memory in human B cells
Authors: Swift Michael , Horns Felix , Quake Stephen R
Published: January 2023

We combined single-cell transcriptomics and lineage tracing to understand fate choice in human B cells. Using the antibody sequences of B cells, we tracked clones during in vitro differentiation. Clonal analysis revealed a subset of IgM+ B cells which were more proliferative than other B-cell types. Whereas the population of B cells adopted diverse states during differentiation, clones had a restricted set of fates available to them; there were two times more single-fate clones than expected given population-level cell-type diversity. This implicated a molecular memory of initial cell states that was propagated through differentiation. We then identified the genes which had strongest coherence within clones. These genes significantly overlapped known B-cell fate determination programs, suggesting the genes which determine cell identity are most robustly controlled on a clonal level. Persistent clonal identities were also observed in human plasma cells from bone marrow, indicating that these transcriptional programs maintain long-term cell identities in vivo. Thus, we show how cell-intrinsic fate bias influences differentiation outcomes in vitro and in vivo.
Post-COVID Inflation Dynamics: Higher for Longer
Authors: Verbrugge Randal J. , Zaman Saeed
Published: January 2023

In the December 2022 Summary of Economic Projections (SEP), the median projection for four-quarter core PCE inflation in the fourth quarter of 2025 is 2.1 percent. This same SEP has unemployment rising by nine-tenths, to 4.6 percent, by the end of 2023. We assess the plausibility of this projection using a specific nonlinear model that embeds an empirically successful nonlinear Phillips curve specification into a structural model, identifying it via an underutilized data-dependent method. We model core PCE inflation using three components that align with those noted by Chair Powell in his December 14, 2022, press conference: housing, core goods, and core-services-less-housing. Our model projects that conditional on the SEP unemployment rate path and a rapid deceleration of core goods prices, core PCE inflation moderates to only 2.75 percent by the end of 2025: inflation will be higher for longer. A deep recession would be necessary to achieve the SEP’s projected inflation path. A simple reduced-form welfare analysis, which abstracts from any danger of inflation expectations becoming unanchored, suggests that such a recession would not be optimal.
Comparative assessment of the effect of titanium dioxide – based nanoparticles on boar germ cells in vitro
Authors: Yavorovsky O.P. , Zazuliak T.S. , Ostapiv D.D. , Riabovol V.M. , Demetska O.V.
Published: January 2023

Modern titanium dioxide nanomaterials, in particular modified with nanosilver, have antiviral, antibacterial, antifungal activity, cytotoxic effects in vitro experiments and can affect germ cells of warm-blooded laboratory animals. The research aims to study the effect of different types of titanium dioxide nanoparticles on the physiological and biochemical characteristics of wild boar germ cells in vitro. When applying the maximum dose (LD50) of the studied nanopowders in all samples, sperm survival was probably lower than in the control: by 41.9% (р<0.001) ‒ under the action of TiO2 nanoparticles (hereinafter NPs) (Frantsevich Institute for Problems of Materials Science of NAS of Ukraine, hereinafter IPM), by 28.0% (р<0.05) ‒ under the action of TiO2 NPs (Acros Organics), by 53.5% (р<0.001) ‒ under the action of 4% Ag-TiO2 NPs (IPM) and by 55.9% (р<0.001) ‒ are the action of NPs 8% Ag-TiO2 (IPM). Nanopowders of different based on titanium dioxide manufacturers, characterized by similar morphological characteristics and varying degrees of nanosilver addition (Ag content from 0 to 8%), starting from a dose of 1/10 LD50, can have a damaging effect on the germ cells of wild boars, which is manifested by a decrease in the respiratory activity of sperm and cytochrome oxidase activity, by increasing succinate dehydrogenase activity. The most sensitive marker was the sperm survival rate, the value of which significantly decreased under the action of 8% Ag-TiO2 nanoparticles (IPM) at a dose of 1/100 LD50, which is a consequence of disruption of the activity of mitochondrial enzymes and, accordingly, resynthesis of ATP. Our results confirm and extend the data on the nature of the damaging effect of titanium dioxide-based nanoparticles on germ cells of warm-blooded animals due to oxidative stress. The obtained experimental data will be taken into account in the hygienic regulation of the investigated nanopowders.
Ensuring of rehabilitation care quality provision: organizational-methodological aspect
Authors: Bezverkhniuk T.M. , Babova I.K.
Published: January 2023

Introduction of international treatment protocols into medical care determines the need for scientific substantiation of the mechanisms of their adaptation in rehabilitation care. On the basis of a systemic approach we substantiated the organizational model of quality assurance for the provision of rehabilitation care in health care system in Ukraine, which consists of four interacting subsystems: management, functional, monitoring (resultative) and supply (process) subsystems. The state of rehabilitation care provision in Ukraine at the expense of the Social Insurance Fund of Ukraine and the National Health Service of Ukraine was analyzed. Need to renovate medical and technological documentation of rehabilitation care for the main groups of socially significant diseases that lead to disability of the population was grounded. Recommended program of rehabilitation at the health-resort stage of patients after coronavirus disease (COVID-19) is proposed for health-resort institutions as a methodical basis for the introduction of updated medical-technological standardization documents, which will contribute to improving the quality of rehabilitation care in Ukraine. Typical (recommended) rehabilitation program consists of general provisions on the organization of rehabilitation care, in particular the existing documentary base; indications, contraindications and criteria for admission to the health-resort stage of rehabilitation (in the post-acute or long-term period); diagnostic plan; regulation of actions in case of deterioration of the patient's clinical condition; approximate duration of the rehabilitation course; tasks of the rehabilitation stage; general characteristics of the resort and available natural healing resources; list of rehabilitation procedures; indicators of the effectiveness of rehabilitation care. The program was implemented in a number of health-resort institutions of Ukraine.
ОСОБЛИВОСТІ РОЗВИТКУ РУХОВИХ ЯКОСТЕЙ ДІТЕЙ ДОШКІЛЬНОГО ВІКУ
Authors: Караулова С. І. , Воронков Є. О. , Потапов К. Ю.
Published: January 2023

Дослідження присвячене проблемі оптимізації системи рухової активності дітей дошкільного віку. Проаналізовано літературу і показано, що дана проблема спрямована на вирішення своєчасного та правильного формування природи фізичної активності з набуттям рухових навичок, що сприяє здоровому фізичному, когнітивному, емоційному та соціальному розвитку дитини. Вивчено вікові та статеві особливості та динаміку прояву рухових якостей дітей дошкільного віку. При порівнянні результатів фізичної підготовленості під впливом програми зміцнення здоров’я та активізації рухового режиму визначено гетерохронність та варіативність розвитку рухових якостей, що вказує на нерівномірність педагогічних впливів у вихованні фізичних якостей, на використання диференційованого підходу до розвитку рухових якостей дітей дошкільного віку. Підтверджено ефективність комплексної програми активізації рухового режиму дітей та рекомендовано впровадження її у систему фізичного виховання у закладах дошкільної освіти України.
Saúde mental discente: qual o papel do professor frente a essa temática?
Authors: Machado Pinheiro Victória , Alves Vargas Leonardo , Sônego Fabricia , Rohr Angela
Published: January 2023

Nos últimos anos percebeu-se um aumento expressivo de casos referentes a transtornos psicológicos na população brasileira, sendo esses identificados principalmente em adolescentes. Essa realidade também é percebida no ambiente educacional, no qual tais questões vêm se apresentando de maneira cada vez mais recorrente dentre os educandos, podendo estar direta ou indiretamente relacionadas a dificuldades no processo de ensino e aprendizagem. Em vista disso, esta pesquisa objetivou responder qual a importância de debates sobre saúde mental para identificar e prevenir transtornos psicológicos, na visão dos educadores que atuam na educação básica. Realizou-se pesquisa qualitativa, utilizando como ferramenta de coleta de dados as entrevistas com professores, que posteriormente foram analisadas e interpretadas por meio da Análise Textual Discursiva, para melhor compreender a percepção dos docentes sobre o tema. Os resultados da pesquisa apontaram que debates sobre saúde mental são imprescindíveis à prevenção e auxílio das dificuldades relacionadas a eles no ambiente escolar.
Analysis of the Application of Ink Art in Graphic Design Imagery
Authors: Wang Ye
Published: January 2023

The graphic design industry has been developing rapidly in recent years. People have begun to focus on steering the development of graphic design in the direction of localization, integrating more traditional Chinese elements, raising the level of acceptance toward graphic design content, and disseminating traditional culture on this basis. Ink art plays an important role in the process of historical and cultural development. It uses simple color contrast to construct different situations and possesses unique artistic charm and cultural heritage. Incorporating ink elements into graphic design may enhance the graphic design style and provide inspiration. This article focuses on the reasons, advantages, and strategies of using ink art in graphic design imagery, hoping to provide references for graphic design activities.
Cómo el lenguaje reconfigura el pensamiento
Authors: Gomila Antoni
Published: January 2023

El desarrollo empírico del programa neo-whorfiano ha sido muy fructífero en la última década. En este trabajo se resumen las investigaciones más notables dentro de este programa, y se discuten sus resultados, para tratar de establecer qué versión de la hipótesis relativista es la que resulta vindicada. Se argumenta que la conclusión que se deriva de estas investigaciones es que el lenguaje reconfigura el pensamiento, transformando las capacidades cognitivas previas. Los efectos relativistas identificados, en cambio, no permiten establecer una conclusión radical respecto a la importancia de las diferencias cognitivas que se siguen de las diferencias lingüísticas de los correspondientes hablantes.
China: la dimensión filosófica de su emergencia internacional
Authors: Yousef Sandoval Laila
Published: January 2023

La presencia de China a nivel global cobra cada vez mayor relevancia en las relaciones internacionales de este siglo. El objetivo de este trabajo es analizar los fundamentos filosófico-políticos que sustentan este avance a través de las nociones de epistemología, tiempo y sustancia presentes en el pensamiento chino para ver de qué manera articulan su cosmovisión política. Se prestará atención a cómo dichos conceptos se relacionan con el legismo y el confucianismo, para dar así con la clave de la posición política china en la actualidad.
Truth in pragmatism. Dewey and Brandom face to face
Authors: Frápolli María José
Published: January 2023

In this paper, I compare the approach to truth characteristic of pragmatism, often identified with warranted assertability, with the prosentential proposal put forward by Robert Brandom. I argue that Brandom´s is a genuine step forward from pragmatism and analytic philosophy, even though his philosophical take includes classic pragmatist features. Furthermore, I show that Dewey and Brandom coincide in their social kind of naturalism, also supported by evolutionary psychology. I conclude that the essential distinction between truth and warranted assertability cannot be exposed without involving an external perspective, the third-person perspective, which is absent in standard pragmatist approaches to truth.
John Dewey's Radical Logic: The Function of the Qualitative in Thinking
Authors: Pappas Gregory Fernando
Published: January 2023

In his later works, John Dewey questioned some of the traditional assumptions about the nature and function of the qualitative in inquiry. Dewey foresaw what recent scientific accounts of human thinking are confirming: it is more complex, less linear, more emotional, affective, bodily-based, non-reflective, non-linguistic, non-conscious than philosophers have assumed. Commentators on Dewey have emphasized how inquiry is social, instrumental, and experimental, but for the most part have neglected the qualitative dimension of inquiry. The first section of this essay outlines the different forms that the neglect of the qualitative has taken in Dewey scholarship. The second addresses what Dewey means by the qualitative. The third presents nine specific functions the qualitative has on thinking (inquiry). The essay concludes in the fourth section with some implications of the view presented on the normative dimension of Dewey’s philosophy, and suggests which promising future inquiries remain open regarding the function of the qualitative in inquiry.
John Dewey: la asertabilidad garantizada como sinécdoque
Authors: González-Castán Óscar Lucas
Published: January 2023

Dewey introduce de una forma problemática las nociones de verdad y conocimiento en el argumento general de su Lógica. Sostiene que el fin de la investigación es producir enunciados que tengan asertabilidad garantizada y equipara, por definición, el conocimiento y la verdad con este tipo de enunciados. Esta estrategia se enfrenta con dificultades que proceden de dos frentes. El primero tiene que ver con la línea de continuidad que Dewey establece entre el comportamiento animal, el comportamiento cotidiano y el comportamiento científico. Si la noción de verdad no es necesaria para describir el primero, tampoco lo será para describir el último. La segunda dificultad procede de los rendimientos epistemológicos que Dewey extrae del cambio de nuestras teorías científicas y de sus aserciones garantizadas. Exploro el papel que el error y la repetición tienen en este ámbito y argumento que la postura de Dewey, sin ser falsa, constituye un caso de metonimia, es decir, de tomar una parte por el todo.
ALISON BECHDEL Y EL SECRETO DE LA FUERZA SOBREHUMANA: EL REGRESO DE UNA PIONERA
Authors: Jiménez Jesús
Published: January 2023

Hay personas que parecen adelantadas a su tiempo, y Alison Bechdel (Pensilvania, 1960) es una de ellas, como vuelve a demostrar con su última obra: El secreto de la fuerza sobrehumana. En ella habla de cuestiones como la decadencia física o la menopausia, que deberían ser habituales en la ficción, pero que todavía siguen siendo temas tabúes.
Claves para el diagnóstico y manejo de femicidio en el primer nivel de atención
Authors: Cepeda Inca Gladys Monserrath , Bedoya Vaca Rita Del Carmen , Cepeda Inca Héctor Eduardo
Published: January 2023

Introducción: Muchas de las mujeres víctimas de femicidio utilizan los servicios de salud un tiempo antes de ser asesinadas por su victimario. Según la Organización Mundial de la Salud, este fenómeno suele ser consecuencia de acontecimientos previos que requieren estrategias de intervención para reducir esta problemática de salud pública.
Biocontrol de Cosmopolites sordidus (Germar) en plantaciones de Musa AAB del Carmen, Manabí, Ecuador
Authors: González Dávila Ricardo Paúl , Vivas Cedeño Jorge , Tacuri Troya Elizabeth Telli , Mendoza Mejía Jorge Luis
Published: January 2023

Debido a la gran influencia que tiene el Cosmopolites sordidus (picudo negro) sobre la producción del cultivo de Musa AAB en la zona de El Carmen, Manabí, Ecuador, se realizó el presente trabajo de investigación en el laboratorio de microbiología de la Universidad Laica Eloy Alfaro de Manabí, Extensión El Carmen, con el objetivo de evaluar cepas monoespóricas y poliespóricas de Beauveria bassiana y Metarhizium anisopliae. La evaluación se realizó en trampas tipo sándwich con cuatro tratamientos y cinco repeticiones en un Diseño Completamente al Azar (DCA). Los resultados obtenidos del seguimiento en 24 días mostraron que la cepa de Metarhizium anisopliae alcanzó el 16% de mortalidad, Beauveria bassiana 74% y la mezcla de los dos hongos el 78 %, lo que indica que se obtuvo mejor control del picudo negro al realizar una mezcla de los hongos, pero esta alternativa es la de mayor costo, por ello la alternativa de mayor factibilidad para los productores en el control del picudo negro es la aplicación de Beauveria bassiana.
Aspergilosis y su impacto en la función pulmonar
Authors: Salcedo Hernández Cristian Javier , Tomalá Salvatierra Ángelo Miguel , Ramírez Amaya Josefina Elizabeth , Arteaga Muñoz Jean Luis
Published: January 2023

La aspergilosis es una infección oportunista que generalmente afecta las vías aéreas inferiores y es causada por la inhalación de esporas del hongo filamentoso Aspergillus, comúnmente presentes en el ambiente. El género Aspergillus define a un conjunto de hongos filamentosos hialinos, miembros anamórficos de la familia Trichocomaceae y que se hallan distribuidas en la naturaleza en una gran variedad de substratos o en suspensión en el ambiente por lo que el ser humano está continuamente expuesto a su inhalación, puede causar un amplio espectro de infecciones en el ser humano que van desde las formas superficiales (otitis externas fúngicas, onicomicosis, queratomicosis, infecciones de heridas y quemaduras) a la aspergilosis profunda invasora que es la que plantea los mayores retos diagnósticos al microbiólogo y al clínico. El objetivo del presente artículo es concientizar a la sociedad sobre sobre lo que es la aspergilosis y el daño que puede causar en la función pulmonar de los seres humanos. Material y Método: Se realizó una revisión bibliográfica de artículos de fuentes como Scielo, Redalyc y autores especializados entre otros, se obtuvieron 36 artículos de los cuales se consideraron 15 para realizar este artículo.
Left-Tail Momentum of Korean Stock Markets
Authors: Eom Cheoljun , Eom Yunsung , Park Jong Won
Published: January 2023

This study examines the relationship between left-tail risk and stock return in the Korean stock markets and ascertains whether there is a left-tail momentum phenomenon in which stocks with high left-tail risk have lower investment performance than those with low left-tail risk (Atilgan et al., 2020). The results reveal that left-tail risk has a significant negative relationship with stock returns for future holding periods and that the left-tail momentum is strongly observed in the Korean stock markets. The excess return of the Fama-French 3-factor model of the decile portfolio-based (H-L) zero-cost investment strategy using left-tail risk has a significant value of -0.67% to -0.73% per month on average. These results are robust even after controlling for changes in the left-tail risk measures or key related variables that could affect the left-tail momentum. In addition, the left-tail momentum has explanatory power regarding the fluctuations of stock returns independent of Fama-French 3-factors.
OUTLINE OF THE FUNCTIONAL PURPOSE, REQUIREMENTS FOR THE COMPOSITION OF EQUIPMENT AND TOOLS FOR COMPLEX HARDWARE COMMUNICATION AND CYBERSECURITY
Authors: Shemendiuk Oleksandr , Kozubtsov Igor , Neshcheret Ivan , Protsiuk Yurii , Bryhadyr Serhii , Fomkin Denys
Published: January 2023

The experience of modern combat use of weapons and military equipment in the full-scale military aggression of the Russian Federation against Ukraine confirmed the need to review the existing requirements not only for individual samples, but in particular for the automobile platform. The automobile base consists of technically outdated equipment brands (Ural, Zil, GAZ, KAMAZ, Maz, UAZ), the manufacturer of which is the USSR, and the modern supplier of spare parts is the Russian Federation. If it was used for more than an operational period in connection, then problems began to arise. Purpose of the article. Justification of the composition of equipment and communication facilities of the complex hardware of the communications and cybersecurity troops of the Armed Forces of Ukraine, depending on the purpose and functional tasks. Materials and methods. To solve the tasks set, a set of theoretical research methods was used: historical analysis and generalization of scientific literature on the research problem; structural and genetic analysis and synthesis when clarifying the object and subject of research; the method of convergence from abstract to concrete; method of analytical and comparative analysis in analytical and comparative assessment of the novelty of research results; synthesis and generalization – to substantiate the methodological and methodological foundations of the study; generalization – the formulation of conclusions and recommendations for continuing further research. The result. The existing fleet of complex hardware Communications was constructed by the forces of the repair bases of the Armed Forces of Ukraine according to the unapproved established order projects for the modernization of command and staff vehicles of the old fleet (R-142 and R-145) (up to type A2M1-04) and re-equipped with the latest models of the hardware of the old fleet type P-258, P-256, P-240, P-241, P-238 and P-178. a variable approach to the choice of the automobile base and the complete set of mobile telecommunications kit and means of communication makes it possible to quickly organize all types of communication in any field conditions.
İngilis dilinin ikinci (xarici) dil kimi tədrisində kommunikativ metodun üstünlükləri və çatışmazlıqları
Authors: Adıgözəlova Leyla
Published: January 2023

Nitqin yarandığı gündən etibarən insanlar müxtəlif xarici dilləri müxtəlif məqsədlərlə öyrənməyə çalışırlar. Müəllimləri və tələbələri daim narahat edən ən vacib məsələlərdən biri “Xarici dili necə öyrətmək”, və ya “Xarici dili necə öyrənmək”  olmuşdur.

XXI əsrə qədər ən geniş yayılan tədris metodu “grammar-translation approach” (qrammatika və tərcümə yanaşması) idi.
Şəxsiyyətin hərtərəfli inkişafında fiziki tərbiyə əsas faktor kimi
Authors: Cəfərova İ. S.
Published: January 2023

Azərbaycan gənclərinin sağlam və fəal həyat tərzini təşviq etmək və onların cəmiyyətə inteqrasiyasını təmin etmək məqsədi ilə 2013-2023-cü illəri əhatə edən Azərbaycan gənclərinin İnkişaf Strategiyası və 2016-2020-ci illər üçün Dövlət Proqramı, bədən tərbiyəsi və idmanın   inkişafı üzrə 2012-2020-ci illəri əhatə edən Milli Strategiya həyata keçirilməkdədir.  Müasir  təhsilin məzmunu təhsilalanların yaş, fizioloji, psixoloji xüsusiyyətləri nəzərə alınmaqla onların dünyagörüşünün və şəxsiyyətinin formalaşmasını, bazar münasibətlərinin tələblərinə uyğun zəruri bilik və bacarıqlara yiyələnməsini, əqli, fiziki, mənəvi, estetik inkişafını, müstəqil əmək və təhsil həyatına hazırlanmasını, cəmiyyətin faydalı və məhsuldar üzvünə çevrilməsini təmin edir.
Şagirdlərin vətəndaş cəmiyyətinə hazırlanmasında intelektual oyunların rolu
Authors: Cəfərov Q. M.
Published: January 2023

Vətəndaş cəmiyyətinin formalaşmasınında məktəb yaşlı uşaqlar xüsusi rola malikdırlər və ona görə də, müasir təhsil sisteminin qarşısında geniş dünya görüşünə və intellektə malik, insanların hüquq və azadlıqlarına hörmətlə yanaşan, vətənini dünyanın qabaqcıl ölkələri arasında layiqincə təmsil edə bilən vətəndaşın tərbiyəsi, günün aktual problemlərindəndir.
Oksidativ stress və oksigenin aktiv formalarının orqanizmə təsiri
Authors: Əliyev S. A. , Babayev M. Ə. , Quliyev Y. N.
Published: January 2023

Orqanizmin adaptasiya reaksiyaları, onların optimallaşdırılmasının mexanizmləri və imkanları, resistentliyinin mühitin müxtəlif ekstremal amillərin təsirinə qarşı yüksəldilməsinin üsullarının axtarışı müasir fiziologiyanın və biokimyanın vacib problemlərindən olaraq qalmalıdır. Müasir dövrdə stressin ən çox yayılmış növlərindən biri fiziki yüklərin təsiridir. Uzunmüddətli və yüksək intensivlikli fiziki yüklərin yaratdığı oksidativ stress, bioloji membranların tamlığını pozan universal mexanizm kimi nəzərdən keçirilir.
Bədii gimnastika üzrə Azərbaycanın yığma komandası üzvlərinin fiziki hazırlığına nəzarət və qiymətləndirmə metodları
Authors: Nərimanov E. Ə. , Bagirov S. S.
Published: January 2023

Beynəlxalq arenada rəqabət – məşq prosesinin idarəetmə sahəsində və idmançıların fiziki qabiliyyətinə olan əsas müasir tələbat elmi tədqiqatla müəyyənləşdirilir.  Təqdim olunan məqalədə eksperimental tədqiqatlar təqdim olunaraq həmin tədqiqatda bədii gimnastika üzrə Azərbaycan Respublikasının  yığma komandası da iştirak etmişdir.