bluuebunny/crossref_metadata_2025 huggingface dataset:
Aux sources de l’ originaire dans le désir d’enseigner
Authors: Cayot Angélique
Published: November 2017

Pris dans la « métaphore vive » du mythe de Pygmalion, le désir d’enseigner s’inscrit dans une dimension narcissique patente actualisant le sentiment de continuité d’existence et la quête d’un idéal du moi qui ne demande qu’à coïncider avec le réel et le projet identitaire. Mais se joue aussi la quête de la différence , une logique ancrée dans l’infantile et le sexuel affrontant inévitablement la différence des sexes et une bisexualité activement mobilisée. Enfin, dans la réciprocité du désir d’apprendre et de savoir, enseigner à l’enfant c’est aller à la rencontre de l’ inconnu de Rosolato et convoquer les fantasmes originaires qui nous traversent tous, rattachés aux questions de la naissance, de la mort et de la scène primitive. Dans l’insistance de la répétition, l’enseignant se fait le passeur, le chercheur des signifiants énigmatiques aux origines de la pensée, porteurs de sens et de désir.
Destins de la temporalité psychique et survivance après un génocide : une étude de cas à partir de la libre réalisation de l’arbre généalogique
Authors: Katz-Gilbert Muriel
Published: November 2017

De nombreux travaux ont permis de montrer qu’un crime de masse a des répercussions psychiques sur plusieurs générations. Pensé comme crime généalogique, le génocide constitue une catastrophe de la filiation. Comment les sujets dont la famille a été menacée d’extermination s’inscrivent-ils fantasmatiquement dans leur lignée généalogique ? C’est à travers une médiation projective originale, la libre réalisation de l’arbre généalogique, que l’on tentera d’explorer cette question dans le cadre d’une étude de cas. Celle-ci porte sur la rencontre avec une femme survivante qui a été cachée pendant la Shoah. L’adéquation méthodologique de ce dispositif pour mettre cette question de recherche clinique au travail sera discutée en lien avec le possible repérage d’une problématique traumatique.
Contribution d’une approche projective à la relance des processus de pensée dans un cas d’enfant en difficulté scolaire
Authors: Meyer Philippe , Thévenot Anne , Metz Claire
Published: November 2017

Les dispositifs de diagnostic et de remédiation plus ou moins rééducatifs pour les élèves en grande difficulté scolaire se multiplient actuellement en France. Pourtant l’importance des déterminants et du fonctionnement psychique à l’œuvre dans les difficultés intellectuelles et cognitives a été mise en évidence par de nombreux auteurs. L’étude longitudinale du cas de Murielle, une enfant présentant une suspicion de dyslexie, puis un diagnostic de déficience légère, et enfin une évolution vers une orientation hors du champ du handicap, nous amène à mettre en évidence l’intérêt des méthodes projectives référées à la psychopathologie clinique, appliquées aux difficultés scolaires. En effet, le fonctionnement mental de l’enfant ainsi mis au jour a permis de repenser radicalement les prises en charge initiales de Murielle. Ce cas interroge aussi l’effet de sidération induit sur les parents par un diagnostic de handicap envisagé comme irréversible.
L’adolescent traducteur
Authors: Andreyev Zoé , Neau Françoise
Published: November 2017

À partir des travaux de Jean Laplanche et de son « modèle traductif », cet article propose de comparer le processus adolescent, tel qu’il est travaillé en psychothérapie, au travail du traducteur. À partir de deux cas cliniques de jeunes adolescentes de 13 ans et 16 ans, nous montrons comment le travail thérapeutique a pris la forme, pour la première, d’une recherche d’une « langue de traduction » permettant des aller-retours entre la langue de la sexualité infantile et la langue, effractante, de la sexualité pubertaire ; et pour la seconde, de « traduire » un actuel traumatique à travers des représentations infantiles. Le travail thérapeutique peut être ainsi vu comme la remise en mouvement d’un processus psychique de « traduction » permettant de retrouver une créativité infantile paralysée par l’excès d’excitation.
Les éprouvés du corps et le corps éprouvé de la fibromyalgie
Authors: Castro de Souza Lélia , Baudin Marianne , Pheulpin Marie-Christine
Published: November 2017

Les patients souffrant de fibromyalgie refusent presque toujours de considérer les composantes psychiques potentielles de leur maladie. À travers le tat , nous observons chez ces personnes une prégnance de la sensorialité ainsi qu’un recours important aux postures corporelles pour signifier des affects qui peinent à s’exprimer. Dans la fibromyalgie c’est le corps éprouvé, le corps douloureux qui est au-devant de la scène. L’enveloppe sensorielle semble fonctionner comme une peau psychique susceptible de contenir l’angoisse et de restaurer quelque chose du sentiment de soi et de la continuité d’exister. Elle parait aussi réitérer l’appel à un objet secourable restant hors d’atteinte. La fatigue, considérée dans ce travail comme une forme de dépression, semble trouver dans la douleur éprouvée sa composante mélancolique.
L’épreuve du pouvoir est-elle vouée à être fatale au Parti socialiste ?
Authors: Sawicki Frédéric
Published: November 2017

La débâcle des socialistes aux élections de 2017 a des causes multiples, qui ne tiennent pas qu’aux politiques menées et aux promesses non tenues. L’incapacité de François Hollande à discipliner sa majorité compte pour beaucoup dans le discrédit qui a frappé à la fois le Président et son parti. Cette incapacité est un effet non anticipé des primaires ouvertes et des choix initiaux opérés par le Président pour composer son gouvernement. En négligeant les rapports de force internes à son parti, François Hollande a affaibli et divisé ce dernier, et l’a conduit à sa perte.
L’étude des partis politiques : entre permanence et renouveau
Authors: Bachelot Carole
Published: November 2017

L’analyse des partis politiques suscite depuis le début du xx e  siècle une littérature foisonnante et diversifiée. Cet article donne un aperçu des évolutions récentes de cette littérature en science politique, en revenant sur les dynamiques qui affectent ses grandes traditions d’analyse (entrepreneuriale, organisationnelle, sociétale) et sur l’apparition de nouveaux « objets partisans » qui invitent à l’hybridation des perspectives et des méthodes.
Destins d’une rencontre
Authors: Aisenstein Marilia , Smadja Claude , Papageorgiou Marina , Chambrier-Slama Josiane
Published: November 2017

Cet entretien avec Marilia Aisenstein et Claude Smadja retrace les liens d’André Green avec Pierre Marty et la psychosomatique de l’École de Paris, en apportant un éclairage sur les convergences et les divergences de leurs théorisations ainsi que sur les prolongements de leur rencontre féconde sur la pensée psychosomatique psychanalytique contemporaine.
La argamasa que une los reinos: gestión e integración de las Indias en la Monarquía Hispánica, siglo XVII
Authors: Ponce Leiva Pilar
Published: November 2017

A partir del símil que considera la administración como una especie de argamasa capaz de mantener unidos los diferentes reinos integrados en la Monarquía Hispánica, el presente texto centra su atención en la judicatura indiana Una vez analizadas la naturaleza, las vías de acceso y los ámbitos de acción de los agentes de justicia, se plantean algunas consideraciones en relación al debate sostenido durante el siglo XVII sobre la posición que las Indias ocupaban, o debían ocupar, en el universo contemplado.
El peso de las jerarquías sociales locales en el orden público: la guardia nacional chilena durante el gobierno de José Joaquín Prieto (1831-1841)
Authors: Douzet Carafí María Teresa
Published: November 2017

Desde comienzos de la década de 1830, la guardia nacional se convierte en el principal instrumento del gobierno del presidente José Joaquín Prieto Vial (1831-1841) para garantizar el orden público en la república de Chile El objetivo de este artículo es mostrar que ello no responde solamente a la voluntad del ejecutivo que fomenta sus funciones defensiva y moralizadora, y en lograr acuerdos políticos para su desarrollo institucional, sino al papel de las jerarquías sociales locales que posibilitan la inserción sociopolítica territorial de la guardia nacional y su funcionamiento.
El «modelo» norteamericano en la reglamentación de las intervenciones federales en la Argentina decimonónica. Debates en el Congreso Nacional (1869 y 1894)
Authors: Cucchi Laura , Romero Ana L.
Published: November 2017

Este trabajo examina el lugar de la legislación de los Estados Unidos como referencia doctrinal en los dos mayores debates legislativos de la Argentina decimonónica acerca de la reglamentación de las facultades del gobierno nacional para intervenir en las provincias.
Property Clustering in Linked Data
Authors: Gong Saisai , Hu Wei , Li Haoxuan , Qu Yuzhong
Published: November 2017

Properties are used to describe entities, and a part of them are likely to be clustered together to constitute an aspect. For example, first name, middle name and last name are usually gathered to describe a person's name. However, existing automated approaches to property clustering remain far from satisfactory for an open domain like Linked Data. In this paper, the authors firstly investigated the relatedness between properties using 13 different measures. Then, they employed seven clustering algorithms and two combination methods for property clustering. Based on a sample set of Linked Data, the authors empirically studied property clustering in Linked Data and found that a proper combination of different measures and clustering algorithms gave rise to the best result. Additionally, they reported how property clustering can improve user experience in an entity browsing system.
Runtime Reusable Weaving Model for Cloud Services Using Aspect-Oriented Programming
Authors: Alsobeh Anas M.R. , Magableh Aws Abed Al Raheem , AlSukhni Emad M.
Published: November 2017

Cloud computing technology has opened an avenue to meet the critical need to securely share distributed resources and web services, and especially those that belong to clients who have sensitive data and applications. However, implementing crosscutting concerns for cloud-based applications is a challenge. This challenge stems from the nature of distributed Web-based technology architecture and infrastructure. One of the key concerns is security logic, which is scattered and tangled across all the cloud service layers. In addition, maintenance and modification of the security aspect is a difficult task. Therefore, cloud services need to be extended by enriching them with features to support adaptation so that these services can become better structured and less complex. Aspect-oriented programming is the right technical solution for this problem as it enables the required separation when implementing security features without the need to change the core code of the server or client in the cloud. Therefore, this article proposes a Runtime Reusable Weaving Model for weaving security-related crosscutting concerns through layers of cloud computing architecture. The proposed model does not require access to the source code of a cloud service and this can make it easier for the client to reuse the needed security-related crosscutting concerns. The proposed model is implemented using aspect orientation techniques to integrate cloud security solutions at the software-as-a-service layer.
Corrigendum: Ileal hypertrophy and associated true diverticulum as a cause of colic in a horse
Authors: Mahne Arnold T. , Janse van Rensburg Drienie D. , Hewetson Michael
Published: November 2017

No abstract available.
Drilling into an active mofette: pilot-hole study of the impact of CO2-rich mantle-derived fluids on the geo–bio interaction in the western Eger Rift (Czech Republic)
Authors: Bussert Robert , Kämpf Horst , Flechsig Christina , Hesse Katja , Nickschick Tobias , Liu Qi , Umlauft Josefine , Vylita Tomáš , Wagner Dirk , Wonik Thomas , Flores Hortencia Estrella , Alawi Mashal
Published: November 2017

Abstract. Microbial life in the continental deep biosphere is closely linked to geodynamic processes, yet this interaction is poorly studied. The Cheb Basin in the western Eger Rift (Czech Republic) is an ideal place for such a study because it displays almost permanent seismic activity along active faults with earthquake swarms up to ML 4.5 and intense degassing of mantle-derived CO2 in conduits that show up at the surface in form of mofettes. We hypothesize that microbial life is significantly accelerated in active fault zones and in CO2 conduits, due to increased fluid and substrate flow. To test this hypothesis, pilot hole HJB-1 was drilled in spring 2016 at the major mofette of the Hartoušov mofette field, after extensive pre-drill surveys to optimize the well location. After drilling through a thin caprock-like structure at 78.5 m, a CO2 blowout occurred indicating a CO2 reservoir in the underlying sandy clay. A pumping test revealed the presence of mineral water dominated by Na+, Ca2+, HCO3−, SO42− (Na-Ca-HCO3-SO4 type) having a temperature of 18.6 °C and a conductivity of 6760 µS cm−1. The high content of sulfate (1470 mg L−1) is typical of Carlsbad Spa mineral waters. The hole penetrated about 90 m of Cenozoic sediments and reached a final depth of 108.50 m in Palaeozoic schists. Core recovery was about 85 %. The cored sediments are mudstones with minor carbonates, sandstones and lignite coals that were deposited in a lacustrine environment. Deformation structures and alteration features are abundant in the core. Ongoing studies will show if they result from the flow of CO2-rich fluids or not.
The Internal Frontier: How Art at Once Problematizes Borders and Draws us Closer to Them
Authors: Ozga Kasia
Published: November 2017

This study combines first-person storytelling, visual interpretation, and linguistic investigation to analyze how a mixed-media artwork that Kasia Ozga produced in 2011, The Internal Frontier, represents immigrant journeys on an autobiographic, social, and discursive level. In the context of an increasingly polarized political climate, Ozga examines borders as individual experiences and geopolitical phenomena to explain how art conditions conflictual aspects of the self to coexist, promoting social consciousness and community engagement.Those in power use borders to naturalize and separate what is familiar from what is strange. As an artist, Ozga explores how our personalities are partitioned, enforced, and made from external boundaries that define our movements, and by the internal borders that we impose on ourselves. Here, reproductions of different “frontiers” around the world are literally cut from the fabric of human chest x-rays collected from immigrant long-term visa applicants, highlighting physical removal and absence. To produce these modified artifacts, shown in light-boxes in various exhibitions in France and the United States, Ozga researched the border-as-process of inclusion and exclusion linked to regulative authority in social relations, nation-building, political sovereignty, as well as personal identity formation.In the artworks, migration is transformed from an isolated act to a shared human experience. The images, at once precise and indeterminate, maintain the dual symbolism of the border as barrier and as springboard, simultaneously inhibiting and enabling interactions between individuals and select geographic locations. Just as migrants lead us to re-evaluate our physical and mental borders, critical cultural production can contest the impact and staying power of borders by underscoring how establishing and overriding boundaries enable us to claim and reclaim who we are.
Zhang Peili: Record. Repeat.
Authors: Larson Ellen
Published: November 2017

Review ofExhibition catalog: Orianna Cacchione, Zhang Peili: Record. Repeat. Exh. Cat. Chicago: Art Institute of Chicago, 2017. 96 pp.; 50 color ills. Hardback $25.00 (9780300226225) Exhibition schedule: Art Institute of Chicago, March 31–July 9, 2017
Fixed point theorem for generalized set-valued contractions on partial metric space
Authors: Abdelouahab MANSOUR , Mostapha Djedidi , Khadra Nachi
Published: November 2017

In this paper, we give a new version of Ekeland’s variationalprinciple on partial metric space. Using this variational principle,we establich a general result on the existence of a fixed point for aclass of genralized set-valued contractions on partiel metric space.
Pollen sources in the Bojanów forest complex identified on honeybee pollen load by microscopic analysis
Authors: Stawiarz Ernest , Żuraw Beata , Marut Agnieszka
Published: November 2017

The aim of this study was to determine sources of pollen for the honeybee in the Bojanów forest complex, Nowa Dęba Forest District (southeastern Poland). Sampling of pollen loads from bees extended from the beginning of May until the end of September 2016 and was carried out at 7-day intervals using pollen traps mounted at the entrance of beehives. A total of 73 pollen load samples were collected from the study area.

Fifty-nine taxa from 31 plant families were identified in the analyzed material. From 4 to 21 taxa (average 9.5) were recorded in one sample. The pollen of Brassicaceae (“others”), Taraxacum type, Solidago type, and Rumex had the highest frequency in the pollen loads examined. Apart from these four taxa, pollen grains of Rubus type, Poaceae (“others”), Calluna, Fagopyrum, Trifolium repens s. l., Phacelia, Aster type, Melampyrum, Quercus, Cornus, and Veronica were recorded in the dominant pollen group. The forest habitat taxa that provided pollen rewards to honeybees in the Bojanów forest complex were the following: Rubus, Calluna, Prunus, Tilia, Frangula alnus, Pinus, Quercus, Cornus, Robinia pseudoacacia, Salix, and Vaccinium. Apart from forest vegetation, the species from meadows and wastelands adjacent to this forest complex, represented by Taraxacum, Rumex, Plantago, Poaceae, Trifolium repens, and Solidago, proved to be an important source of pollen. The study indicates that forest communities are a valuable source of pollen for pollinating insects from early spring through to late fall.
EFFICIENCY OF AGRICULTURAL FARMS IN POLAND IN 2012-2015 DEPENDING ON THEIR ECONOMIC SIZE
Authors: Gałecka Agnieszka
Published: November 2017

The article assesses the level of effectiveness of farms in Poland depending on the economic size. The analysis included agricultural farms participating in the Polish FADN. The study period covered the years 2012-2015. It was found that with the increase in economic size of farms increased productivity of land, labor and capital and labor productivity. In the case of land profitability, return on assets and return on equity growing trend appeared to economic size SO 500 thousand euros, while the above indicators were analyzed on a much lower level. In addition, during the period considered, there was a decrease in the efficiency of agricultural farms in Poland, which is unfavorable.
INEQUALITIES IN HEALTH CONDITION OF RESIDENTS OF EUROPEAN
UNION COUNTRIES – ANALYSIS OF CITY – VILLAGE RELATIONS
Authors: Jakubowska Agnieszka , Rosa Anna
Published: November 2017

The aim of the article is to assess the health inequalities in the European Union countries, analyzed in
terms of “city-village” in the context of their impact on the potential of human capital. In the research problem,
the authors used literature analysis and the data available from Eurostat for EU Member States (NUTS-1).
For the purposes of this study, the authors identified the population of men and women in two age groups.
The level of self-assessment of the health status of hybrids of EU rural and urban areas was analyzed. The
results showed a significantly higher level of health inequality in the “city-country” relationship in the
Central and Eastern European member states.
FUNDS AND PROGRAMS FOR SUPPORTING EDUCATION IN RURAL AREAS IN POLAND
Authors: Kondratowicz-Pozorska Jolanta
Published: November 2017

The aim of this paper is to present the different forms of support and the accompanying them sources of funding which were allocated for the education and development of the rural population between 2002 and 2016 and define the effects of these activities. A number of the EU policies, programs (including national ones), offers of various foundations for the rural population have been reviewed. Scientific literature, empirical materials and description of the EU and national institutions have been studied, as well as programs supporting the economic and social development of rural areas in Poland. The data required to write the article come from research institutions such as IRWiR, IERiGŻ and available GUS’s and The World Bank’s publications.
Descrição de contingências durante a leitura de histórias e o comportamento de crianças: um estudo exploratório
Authors: Gonçalves Meira de Almeida Christiana , Almeida-Verdu Ana Claudia Moreira , Cavalcante Maria Regina
Published: November 2017

O estudo investigou os efeitos da descrição de contingências durante a leitura de histórias sobre o comportamento de crianças entre 8 e 10 anos. No grupo 1, duas crianças foram expostas à uma história com desfecho positivo para o comportamento-alvo de pegar doces antes da festa (A) e, em seguida, outra história com desfecho aversivo (B). No grupo 2, outras duas crianças foram expostas às mesmas histórias na ordem inversa. No grupo 3, três crianças ouviram duas histórias (C e D) sobre festa de aniversário, mas sem menção do comportamento-alvo. Após cada leitura, as crianças eram deixadas em situação similar à descrita nas histórias. A frequência de comportamentos direcionados aos doces foi registrada, sendo maior após a leitura da história A do que após a leitura da história B. Sugere-se que a descrição das contingências durante a narração das histórias controlou o desempenho subsequente dos participantes. 
Análise comparativa dos quadros de ação coletiva das mulheres indígenas
Authors: Morales Martínez Celeste , García Oramas María José
Published: November 2017

O objetivo dessa pesquisa é comparar os elementos associados à participação coletiva de mulheres indígenas pertencentes a duas organizações de direitos humanos, Kalli Luz Marina (México) e Federação Regional de Mulheres Asháninkas, Nomatsiguengas e Kakintes da Selva Central (Peru), com base na perspectiva de gênero. Efetuou-se uma análise qualitativa por entrevistas semiestruturadas realizadas com as participantes, além de investigação dos arquivos das organizações. Verificou-se que a organização das mulheres indígenas é motivada pela percepção de injustiça, a capacidade de agência, identidade coletiva e emoções presentes no processo, o que as leva a mobilizar-se e a manter-se em seus grupos, com uma participação ativa, buscando relações de gênero equitativas. As organizações de mulheres nahuas, asháninkas e nomatsiguengas contribuem para a criação de espaços de encontro para seus pares e fornecem elementos relevantes para o desenvolvimento de atividades de gênero culturalmente situadas.
Comprometimento organizacional: questões que cercam sua natureza e os seus limites conceituais
Authors: Menezes Igor Gomes , Aguiar Carolina Villa Nova , Bastos Antonio Virgilio Bittencourt
Published: November 2017

O comprometimento organizacional, um dos fenômenos mais investigados no campo do comportamento organizacional, pode ser considerado um construto polissêmico e multifacetado. Este trabalho buscou discutir a complexidade e dispersão que cerca o conceito de comprometimento organizacional, envolvendo três problemas centrais: 1º) a quantidade de interfaces teóricas entre comprometimento organizacional e outros construtos da área organizacional; 2º) o grande desequilíbrio entre estudos que tomam o construto como uma atitude em detrimento de definições que enfatizem indicadores comportamentais; e 3º) a dimensionalidade do construto e a falta de consenso a respeito de quantas e quais são as bases constitutivas do comprometimento organizacional. Além de sistematizar os principais problemas sobre o construto, este estudo sugere alguns caminhos de investigação teórica e empírica que poderiam minimizar os problemas que cercam esta vertente de pesquisa, em razão das questões conceituais que caracterizam o seu construto central. 
Fostering Persistence: 3D Printing and the Unforeseen Impact on Equity
Authors: FitzPatrick Daniel L. , Dominguez Victoria S.
Published: November 2017

A professor and a preservice teacher take some risks constructing a “homemade” printer.
Time-gated detection of protein-protein interactions with transcriptional readout
Authors: Kim Min Woo , Wang Wenjing , Sanchez Mateo I , Coukos Robert , von Zastrow Mark , Ting Alice Y
Published: November 2017

Transcriptional assays, such as yeast two-hybrid and TANGO, that convert transient protein-protein interactions (PPIs) into stable expression of transgenes are powerful tools for PPI discovery, screens, and analysis of cell populations. However, such assays often have high background and lose information about PPI dynamics. We have developed SPARK (Specific Protein Association tool giving transcriptional Readout with rapid Kinetics), in which proteolytic release of a membrane-tethered transcription factor (TF) requires both a PPI to deliver a protease proximal to its cleavage peptide and blue light to uncage the cleavage site. SPARK was used to detect 12 different PPIs in mammalian cells, with 5 min temporal resolution and signal ratios up to 37. By shifting the light window, we could reconstruct PPI time-courses. Combined with FACS, SPARK enabled 51 fold enrichment of PPI-positive over PPI-negative cells. Due to its high specificity and sensitivity, SPARK has the potential to advance PPI analysis and discovery.
Determining Children’s Level of Acquisition through Grammatical Profiles: Evidence from a Bilingual Russian-English Child Acquiring Verbs
Authors: Tsfasman Maria
Published: November 2017

In this paper, I present my research on verb acquisition of a bilingual Russian- English child. I apply grammatical profiles to determine the level of acquisition of the child, noticing that grammatical profiles are different for spoken and written language. I show that the bilingual child I examined has acquired the Russian verb system completely, but still makes some mistakes in verb formation.
BGDMdocker: a Docker workflow for data mining and visualization of bacterial pan-genomes and biosynthetic gene clusters
Authors: Cheng Gong , Lu Quan , Ma Ling , Zhang Guocai , Xu Liang , Zhou Zongshan
Published: November 2017

Recently, Docker technology has received increasing attention throughout the bioinformatics community. However, its implementation has not yet been mastered by most biologists; accordingly, its application in biological research has been limited. In order to popularize this technology in the field of bioinformatics and to promote the use of publicly available bioinformatics tools, such as Dockerfiles and Images from communities, government sources, and private owners in the Docker Hub Registry and other Docker-based resources, we introduce here a complete and accurate bioinformatics workflow based on Docker. The present workflow enables analysis and visualization of pan-genomes and biosynthetic gene clusters of bacteria. This provides a new solution for bioinformatics mining of big data from various publicly available biological databases. The present step-by-step guide creates an integrative workflow through a Dockerfile to allow researchers to build their own Image and run Container easily.
Lack of additional effects of long‐term, low‐dose clarithromycin combined treatment compared with topical steroids alone for chronic rhinosinusitis in China: a randomized, controlled trial
Authors: Deng Jie , Chen Fenghong , Lai YinYan , Luo Qing , Xu Rui , Ou Chunquan , Fu Qingling , Shi Jianbo
Published: November 2017

Background

In China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was to determine whether a topical steroid and clarithromycin combination is better than a single topical steroid for Chinese patients with CRS.

Methods

Patients with CRS with/without nasal polyps were included in this study and randomly assigned to a clarithromycin plus budesonide aqua nasal spray group (CLM + BUD, clarithromycin 0.25 g/d and budesonide 256 μg/d) or a budesonide‐alone group (BUD, budesonide 256 μg/d). The treatment period was 3 months. The primary outcome was visual analog scale (VAS) score for 5 major symptoms and a general nasal symptom. Other assessments included the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), computed tomography scan (Lund‐Mackay score), and rigid nasal endoscopy (Lund‐Kennedy score). Nasal secretion evaluation was the secondary outcome.

Results

Seventy‐four patients were included and randomly assigned to the CLM + BUD group (n = 38) or the BUD group (n = 36). VAS scores for nasal obstruction, rhinorrhea, smell reduction, headache, nasal pain, and general nasal symptom were markedly improved in both treatment arms, but the differences between groups were not significant. Furthermore, SNOT‐22, Lund‐Mackay, and Lund‐Kennedy scores improved significantly after treatment in both groups, and were slightly better in the CLM + BUD group. For the responders in the CLM + BUD group, interleukin (IL)‐6 and IL‐8 were markedly reduced.

Conclusion

The combination of CLM + BUD for the treatment of first‐time‐diagnosed CRS in this Chinese population cohort did not show a better effect compared with a single BUD regimen, but it may have a better effect in some patients with increased IL‐6 or IL‐8.
Interactions between two-spotted spider mite, Tetranychus urticae and greenhouse whitefly, Trialeurodes vaporariorum on strawberry
Authors: Mortazavi Nasimeh , Fathipour Yaghoub , Talebi Ali Asghar
Published: November 2017

The interspecific competition is a widespread phenomenon among the herbivores and is an important factor in shaping the herbivore communities. Plants usually mediate competition among herbivores via induced resistance, which can affect pest density, either by altering the performance or host preference of herbivores. The strawberry plants host the two-spotted spider mites (TSSM), Tetranychus urticae Koch and greenhouse whitefly (GHWF), Trialeurodes vaporariorum (Westwood) in greenhouses. We clearly observed the adverse effect of TSSM or GHWF prevalence on colonization and outbreak of the other one, therefore the possibility exists that feeding-induced changes in plant and interspecific competition are the effective factors in shaping their densities. In this study, laboratory experiments were carried out to determine whether previous feeding by TSSM on strawberry (Camarosa variety) affects the performance and oviposition preference of GHWF (as a competitor), and vice versa. Lower egg number, and the slower development as well as delayed oviposition were observed when the pests fed on infested leaves than control leaves. Furthermore, when the pests were given the choice between the non-infested and infested leaves, both pests significantly preferred the non-infested leaves. Our study concluded that feeding-induced changes in quality of host plant adversely affected the performance and oviposition preference of both pests. We suggested that these results can help to explain the different population densities of pests in presence and absence of other species and can attract the attention of farmers to the effects of interspecific competition on the densities of pests.
Post-cataract eye drops can be avoided by depot steroid injections
Authors: Buchan John C , Cleveland Victoria , Sutton Heather , Cassels-Brown Andy
Published: November 2017

There are over 400 000 cataract operations now being performed annually in the UK. With the majority of those patients being older people, comorbidities such as dementia or arthritis can prevent patients putting in their own post-operative eye drops. Where there is a lack of family or other support, district nursing services are often called upon to administer these eye drops, which are typically prescribed four times a day for 4 weeks, thus potentially totalling 112 visits for drop instillation per patient.

To reduce the burden of these post-operative eye drops on district nursing services, administration of an intra-operative sub-Tenon's depot steroid injection is possible for cataract patients who then do not require any post-operative drop instillation. As a trial of this practice, 16 such patients were injected in one year, thus providing a reduction of 1792 in the number of visits requested. Taking an estimated cost of each district nurse visit of £38, this shift in practice potentially saved more than £68 000; the additional cost of the injection over the cost of eye drops was just £8.80 for the year. This practice presents an opportunity to protect valuable community nursing resources, but advocacy for change in practice would be needed with secondary care, or via commissioners.
Maintaining a Strong Signal and Strong Impact
Authors: Knipp Delores J. , Hapgood Mike A. , Welling Dan T.
Published: November 2017

We discuss measures of the Space Weather Journal impact and influence.
Initiated Chemical Vapor Deposition: A Versatile Tool for Various Device Applications
Authors: Yu Seung Jung , Pak Kwanyong , Kwak Moo Jin , Joo Munkyu , Kim Bong Jun , Oh Myung Seok , Baek Jieung , Park Hongkeun , Choi Goro , Kim Do Heung , Choi Junhwan , Choi Yunho , Shin Jihye , Moon Heeyeon , Lee Eunjung , Im Sung Gap
Published: November 2017

Advances in device technology have been accompanied by the development of new types of materials and device fabrication methods. Considering device design, initiated chemical vapor deposition (iCVD) inspires innovation as a platform technology that extends the application range of a material or device. iCVD serves as a versatile tool for surface modification using functional thin film. The building of polymeric thin films from vapor phase monomers is highly desirable for the surface modification of thermally sensitive substrates. The precise control of thin film thicknesses can be achieved using iCVD, creating a conformal coating on nano‐, and micro‐structured substrates such as membranes and microfluidics. iCVD allows for the deposition of polymer thin films of high chemical functionality, and thus, substrate surfaces can be functionalized directly from the iCVD polymer film or can selectively gain functionality through chemical reactions between functional groups on the substrate and other reactive molecules. These beneficial aspects of iCVD can spur breakthroughs in device fabrication based on the deposition of robust and functional polymer thin films. This review describes significant implications of and recent progress made in iCVD‐based technologies in three fields: electronic devices, surface engineering, and biomedical applications.
WTP for baby milk formula in China: Using attribute nonattendance as a priori information to select attributes in choice experiment
Authors: Quan Shiwen , Zeng Yinchu , Yu Xiaohua , Bao Te
Published: November 2017

It is well‐known that these nonattended attributes in choice experiments (CE) could cause some bias. A combination of two successive CEs are designed with focus on consumers’ demand for the attributes of baby milk formula in China, where the first CE includes the full set of attributes and the second excludes consumers’ self‐reported nonattended attributes in the first CE. Significant discrepancies are detected for both WTPs for an individual attribute and the total WTPs (the sum of all WTPs for individual attributes in each CE), and in most cases WTPs decrease as a result of excluding the ignored attributes. Changes in WTP are mainly driven by the variation of choice task complexity. However, there is no significant difference in the influence of excluding nonattended attributes on the WTPs for the same attended attribute in different subsamples. In addition, we also find that consumers in China have significantly higher but dispersed WTP values for imported (11.6–47.0%), organic (6.9–52.5%), and probiotics (7.3–35.5%) and sugar‐free (5.9–26.0%) attributes for baby milk formula. [EconLit citations: C90, D12, Q13, Q18].
Riboflavin transporter deficiency mimicking mitochondrial myopathy caused by complex II deficiency
Authors: Nimmo Graeme A. M. , Ejaz Resham , Cordeiro Dawn , Kannu Peter , Mercimek‐Andrews Saadet
Published: November 2017

Biallelic likely pathogenic variants in SLC52A2 and SLC52A3 cause riboflavin transporter deficiency. It is characterized by muscle weakness, ataxia, progressive ponto‐bulbar palsy, amyotrophy, and sensorineural hearing loss. Oral riboflavin halts disease progression and may reverse symptoms. We report two new patients whose clinical and biochemical features were mimicking mitochondrial myopathy. Patient 1 is an 8‐year‐old male with global developmental delay, axial and appendicular hypotonia, ataxia, and sensorineural hearing loss. His muscle biopsy showed complex II deficiency and ragged red fibers consistent with mitochondrial myopathy. Whole exome sequencing revealed a homozygous likely pathogenic variant in SLC52A2 (c.917G>A; p.Gly306Glu). Patient 2 is a 14‐month‐old boy with global developmental delay, respiratory insufficiency requiring ventilator support within the first year of life. His muscle biopsy revealed combined complex II + III deficiency and ragged red fibers consistent with mitochondrial myopathy. Whole exome sequencing identified a homozygous likely pathogenic variant in SCL52A3 (c.1223G>A; p.Gly408Asp). We report two new patients with riboflavin transporter deficiency, caused by mutations in two different riboflavin transporter genes. Both patients presented with complex II deficiency. This treatable neurometabolic disorder can mimic mitochondrial myopathy. In patients with complex II deficiency, riboflavin transporter deficiency should be included in the differential diagnosis to allow early treatment and improve neurodevelopmental outcome.
Kreisförmiger lichtinduzierter Elektronentransfer in einer Donor‐ Akzeptor‐Akzeptor‐Triade
Authors: Larsen Christopher B. , Wenger Oliver S.
Published: November 2017

Eine Elektronen‐Donor‐Akzeptor‐Akzeptor(D‐A1‐A2)‐Triade liefert die erste direkte Evidenz für die Realisierung des Konzepts eines lichtinduzierten molekularen Stromkreises. Nach Lichtanregung in einen optischen Ladungstransferübergang zwischen D und A1 sowie anschließendem thermischem Elektronentransfer von A1.− auf A2 folgt eine geometrische Reorganisation im ladungsgetrennten D.+‐A1‐A2.−‐Zustand mit Bildung eines Ionenpaarkontakts. Dies ermöglicht eine “Vorwärts”‐Ladungsrekombination zwischen A2.− und D.+, die den molekularen Stromkreis mit einer geschätzten Quanteneffizienz von 4 % in Toluol bei 298 K schließt.
Circular Photoinduced Electron Transfer in a Donor‐Acceptor‐Acceptor Triad
Authors: Larsen Christopher B. , Wenger Oliver S.
Published: November 2017

An electron‐donor‐acceptor‐acceptor (D‐A1‐A2) triad has been developed that provides the first proof‐of‐concept for a photoinitiated molecular circuit. After photoexcitation into an optical charge‐transfer transition between D and A1, subsequent thermal electron‐transfer from A1.− to A2 is followed by geometric rearrangement in the D.+‐A1‐A2.− charge‐separated state to form an ion‐pair contact. This facilitates “forward” charge recombination between A2.− and D.+ to complete the molecular circuit with an estimated quantum efficiency of 4 % in toluene at 298 K.
A low‐cost clay‐based heterogeneous Fenton‐like catalyst: Activation, efficiency enhancement, and mechanism study
Authors: Liu Zhengjiang , Ma Huiyan , Liu Juming , Xing Lei , Cheng Lin , Yang Jucai , Mao Baodong , Zhang Qiancheng
Published: November 2017

In this work, Hangjin2# clay (HC), a natural iron‐contained clay mineral first discovered in Inner Mongolia of China, is found to be able to catalyze the heterogeneous Fenton reaction efficiently upon rational modification. After activation using dilute sulfuric acid, the HC prohibited a significantly enhanced activity for heterogeneous Fenton reaction. Via acid activation process, Fe2+/Fe3+ redox can be introduced on the surface of sulfuric acid‐activated Hangjin2# clay (SHC), and Brønsted acid sites can be also created on the surface of SHC. Furthermore, Brønsted acid sites could effectively promote the generation of •OH for methyl orange (MO) oxidation and facilitate the Fe3+/Fe2+ redox process. Fenton degradation of MO was used to evaluate the effect of acid activation on the catalytic activities of SHC. Experimental results revealed that the high activity of SHC was mainly attributed to the synergetic effect of the abundant acid sites on catalyst surface and the Fe3+/Fe2+ redox process. In addition, quenching studies confirmed that •OH radicals were principally responsible for the degradation of MO. More importantly, MO degradation for 3 consecutive cycles demonstrated SHC exhibited reusable and stable activity.
RNA interference‐mediated knockdown and virus‐induced suppression of Troponin C gene adversely affect the behavior or fitness of the green rice leafhopper, Nephotettix cincticeps
Authors: Lan Hanhong , Hong Xiaojing , Huang Ranran , Lin Xin , Li Qinghuang , Li Kaihui , Zhou Tao
Published: November 2017

The green rice leafhopper, Nephotettix cincticeps, is a major rice pest in Southeast Asia and Southern China. Novel control strategies must be explored to control the rice pest. Behavior or fitness regulation of insect by modulating the Troponin C (TnC) may be a novel strategy in the comprehensive management of the insect pest. However, characterizations and functions of TnC, especially regarding effect of its RNA interference‐mediated gene knockdown on the behavior or fitness of N. cincticeps remain unknown. Here, we successfully cloned and characterized TnC gene from N. cincticeps (Nc‐TnC). We demonstrated that Nc‐TnC ubiquitously transcribed at all development stages and special tissues in adult insects, with relative higher levels at the adult stage and in the intestinal canal. Microinjection‐ or oral membrane feeding‐based transient knockdown of Nc‐TnC adversely affected the performance or fitness, such as the decreased survival, feeding capacity, weight, and fecundity of N. cincticeps. Furthermore, we revealed that the expression of Nc‐TnC was suppressed by its interaction with rice dwarf virus‐encoded nonstructural protein 10, which ultimately affected detrimentally the corresponding parameters of the performance or fitness of N. cincticeps. In conclusion, our data deepen understanding of Nc‐TnC functions during the development of and viral infection in N. cincticeps. It imply Nc‐TnC may serve as a potential target for N. cincticeps control in future.
Alga‐Made Anti‐Hepatitis B Antibody Binds to Human Fcγ Receptors
Authors: Vanier Gaëtan , Stelter Szymon , Vanier Jessica , Hempel Franziska , Maier Uwe G. , Lerouge Patrice , Ma Julian , Bardor Muriel
Published: November 2017

Microalgae are unicellular eukaryotic organisms which represent an emerging alternative to other cell biofactories commonly used to produce monoclonal antibodies. Microalgae display several biotechnological advantages such as their rapid growth rate and their phototrophic lifestyle allowing low production costs as protein expression is solar‐fueled. Recently, a fully assembled recombinant IgG antibody directed against Hepatitis B surface antigen is produced and secreted in the culture medium of the diatom Phaeodactylum tricornutum. A biochemical characterization of this recombinant antibody demonstrated that the Asn‐297 is N‐glycosylated by oligomannosides. In the immune system, antibodies interact with effector molecules and cells through their Fc part and the recognition of Fcγ receptors (FcγR) which are important for inducing phagocytosis of opsonized microbes. Interactions between IgG and FcγR are influenced by the N‐glycan structures present on the Asn‐297. In this study, the authors characterized the binding capacity of the anti‐hepatitis B recombinant IgG produced in P. tricornutum to two human Fcγ receptors (FcγRI and IIIa) using a cellular binding assay and surface plasmon resonance (SPR). This allowed us to demonstrate that the alga‐made antibody is able to bind FcγRI with a reduced affinity and engages FcyRIIIa with 3‐times higher affinity compared to a control human IgG1.
Unravelling the Carbohydrate‐Binding Preferences of the Carbohydrate‐Binding Modules of AMP‐Activated Protein Kinase
Authors: Mobbs Jesse I. , Di Paolo Alex , Metcalfe Riley D. , Selig Emily , Stapleton David I. , Griffin Michael D. W. , Gooley Paul R.
Published: November 2017

The β subunit of adenosine monophosphate (AMP)‐activated protein kinase (AMPK), which exists as two isoforms (β1 and β2) in humans, has a carbohydrate‐binding module (CBM) that interacts with glycogen. Although the β1‐ and β2‐CBMs are structurally similar, with strictly conserved ligand‐contact residues, they show different carbohydrate affinities. β2‐CBM shows the strongest affinity for both branched and unbranched oligosaccharides and it has recently been shown that a Thr insertion into β2‐CBM (Thr101) forms a pocket to accommodate branches. This insertion does not explain why β2‐CBM binds all carbohydrates with stronger affinity. Herein, it is shown that residue 134 (Val for β2 and Thr for β1), which does not come into contact with a carbohydrate, appears to account for the affinity difference. Characterisation by NMR spectroscopy, however, suggests that mutant β2‐Thr101Δ/Val134Thr differs from that of β1‐CBM, and mutant β1‐Thr101ins/Thr134Val differs from that of β2‐CBM. Furthermore, these mutants are less stable to chemical denaturation, relative to that of wild‐type β‐CBMs, which confounds the affinity analyses. To support the importance of Thr101 and Val134, the ancestral CBM has been constructed. This CBM retains Thr101 and Val134, which suggests that the extant β1‐CBM has a modest loss of function in carbohydrate binding. Because the ancestor bound carbohydrate with equal affinity to that of β2‐CBM, it is concluded that residue 134 plays an indirect role in carbohydrate binding.
[Ni3(HCOO)6]/Poly(styrene‐b‐butadiene‐b‐styrene) Mixed‐Matrix Membranes for CH4/N2 Gas Separation
Authors: Wang Shumin , Guo Qingping , Liang Shujun , Li Peng , Li Xin , Luo Jujie
Published: November 2017

For the evaluation of CH4/N2 separation, mixed‐matrix membranes (MMMs) were fabricated by adding [Ni3(HCOO)6] as a filler into the poly(styrene‐b‐butadiene‐b‐styrene) (SBS) polymer. The structures and morphologies of [Ni3(HCOO)6] and [Ni3(HCOO)6]/SBS MMMs were characterized by different techniques, proving the crystalline structure of [Ni3(HCOO)6] in SBS polymer matrices. The structural integrity of the MMMs and good compatibility between [Ni3(HCOO)6] and SBS polymer were examined by scanning electron microscopy. Gas permeation measurements revealed that membranes containing various [Ni3(HCOO)6] loadings exhibited different separation performances. The operational temperature exerted a significantly positive effect on the separation of CH4 and N2.