bluuebunny/crossref_metadata_2025 huggingface dataset:
Simultaneous Determination of Two Metabolites of Gelsemium elegans by
LC-MS/MS in Rat Urine and its Application to Pharmacokinetic Study
Authors: Yan Rui , Zhang Shan
Published: November 2023

Background:

G. elegans is a highly useful medicinal plant with broad and superior
clinical pharmacological effects. However, it also exhibits high toxicity to humans, so it must be
used with extreme caution in clinical practice. Previous studies on G. elegans have mainly focused on its main ingredients from perspectives of pharmaceutical analysis, pharmacokinetics,
and pharmacodynamics. The kinetic behavior of G. elegans' main metabolites in vivo has not yet
been reported, which is also crucial for studying the herb's toxification and detoxification process.

Aims:

This study aimed to establish a quantitative method to describe the metabolic profile of
the two main metabolites of koumine after oral administration of G. elegans to rats.

Objective:

The objective of this study was to test two major metabolites of G. elegans in rat urine
after administration using a rapid and sensitive high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method developed in advance.

Methods:

A Kromasil C18 column was used as the stationary phase for chromatographic separation, with an isocratic mobile phase consisting of mixture of water (2 mM ammonium formate),
formic acid, and methanol (25:0.05:75, v/v/v) at a flow rate of 0.40 mL/min. The mass spectrometer was equipped with an electrospray ionization (ESI) source operating in positive ionization
mode, and detection was performed using a selective reaction monitoring (SRM) mode. Detection was performed in selective reaction monitoring (SRM) mode. Protein precipitation was used
to pretreat the rat urine samples before analysis, with acetonitrile as the precipitation solvent. In
this study, a "relative quantification" strategy was employed, which avoided the expensive and
time-consuming separation of standard substances. The assay was validated in terms of specificity, linearity, precision, stability, recovery, and other aspects.

Results:

The intra- and inter-day precision values were less than 12.7%. The recoveries at three
different concentrations were all above 73.1%. The stability study showed that the analytes were
stable during the experiment. The method was then used to study the kinetic profiles of N-demethylkoumine and N-oxidatekoumine in rat urine for the first time.

Conclusion:

In this study, the established LC/MS method was fully validated and proven to be
sensitive and accurate for the simultaneous determination of the two main metabolites of G. elegans in rats' urine samples. These results could provide references for the safe use of koumine
and G. elegans in clinical applications.
Dropout or Drop-In Experiences in an Internet-Delivered Intervention to Prevent Depression and Enhance Subjective Well-Being During the Perinatal Period: Qualitative Study
Authors: Valla Lisbeth , Haga Silje Marie , Garthus-Niegel Susan , Drozd Filip
Published: November 2023

Background

The perinatal period is a vulnerable time when women are at increased risk of depression. “Mamma Mia” is a universal preventive internet-delivered intervention offered to pregnant women, with the primary goals of preventing the onset or worsening of depression and enhancing subjective well-being during the perinatal period. However, treatment dropout from internet-delivered interventions is often reported.

Objective

The study aim was to acquire an understanding of the different experiences among participants who dropped out of the Mamma Mia intervention during pregnancy, compared to participants who dropped out during the postpartum follow-up phase.

Methods

A total of 16 women from a larger randomized controlled trial (Mamma Mia) participated in individual semistructured interviews following a strengths, weaknesses, opportunities, and threats format. Of the 16 participants included, 8 (50%) women dropped out early from the intervention during pregnancy (pregnancy group), whereas 8 (50%) women dropped out later, after giving birth (postpartum follow-up group). Data were analyzed using the framework approach.

Results

The results showed that there were differences between the groups. In general, more participants in the postpartum follow-up group reported that the program was user-friendly. They became more aware of their own thoughts and feelings and perceived that the program had provided them with more new knowledge and practical information than participants in the pregnancy group. Participants in both groups suggested several opportunities for improving the program.

Conclusions

There were differences between women who dropped out of the intervention during pregnancy and the postpartum follow-up phase. The reported differences between groups should be further examined.
Sex Differences in Pain Sensitivity in a Dutch Cohort: Cross-Sectional and Web-Based Multidimensional Study (Preprint)
Authors: Smits Rachel J H , van der Wal Selina E I , van Boekel Regina L M , Timmerman Hans , Bronkhorst Ewald M , Abrar Diana , Vissers Kris C P , Blaney Davidson Esmeralda N , Steegers Monique A H
Published: November 2023

BACKGROUND

Sex is an important factor influencing the development and treatment of chronic pain, but the extent of its influence is still unclear. Other demographic factors as well as nonpharmacological interventions might influence pain sensitivity differently in men and women.

OBJECTIVE

In this study, we aimed to investigate the influence of sex and other demographic, lifestyle, behavioral, clinical, and environmental factors on pain sensitivity in the Dutch population. Different films were used to investigate how they would impact pain sensitivity and what influence sex and other variables have on the effect of this simple intervention.

METHODS

We performed a study consisting of 2 parts: (1) a cross-sectional research to investigate pain sensitivity differences between men and women and the influence of other demographic variables on the pain sensitivity in a Dutch cohort and (2) an internet intervention study to determine whether a short film could skew pain sensitivity.

RESULTS

All respondents filled in a web-based demographic questionnaire and were randomized into 4 groups. The control group filled in the Pain Sensitivity Questionnaire without watching a preliminary film. A cross-sectional analysis was performed in the control group (n=1746). The other 3 groups watched short films: one group watched a film with scenes of nature (n=2650), another group watched a film on laughing people (n=2735), and the last group watched a film on physically painful events (n=2708). Immediately after the film viewing, participants were directed to the Pain Sensitivity Questionnaire to measure their pain sensitivity. The Pain Sensitivity Questionnaire score was stated as a mean per question on the numeric rating scale from 0-1. The cross-sectional study revealed no significant differences between men and women but showed male-female differences in the Pain Sensitivity Questionnaire when specific background factors were present. Watching a short film had a positive impact on the pain sensitivity of the respondents who had chronic pain, with a higher effect observed in female respondents.

CONCLUSIONS

Scientists performing pain research need to account for factors that can influence the outcome of their study and be aware that these factors can be sex-dependent, and pain sensitivity should be analyzed accordingly. Even relatively small interventions such as watching a film can impact pain sensitivity, especially in respondents with current chronic pain. This effect can vary as well when different background factors are present. Our findings warrant further explorations of the possibilities that simple interventions bring for patients in personalized medicine.

CLINICALTRIAL

Landelijk Trial Register NTR-new NL8182; https://onderzoekmetmensen.nl/en/trial/29537
Enhancing security in data sharing between practitioners: a qualitative study (Preprint)
Authors: Manns Aurélia , Pezziardi Thomas , Kadlub Natacha , Burgun Anita , Destrez Alban , Tsopra Rosy
Published: November 2023

BACKGROUND

The digital transition has considerably increased the number of data exchanged in healthcare, with new risks related to security and ethics. Health professionals may have difficulties to consider security during data sharing because of technical and environmental constraints.

OBJECTIVE

Here, we aim at understanding how to help them to better consider security during data sharing.

METHODS

We conducted a qualitative research with 20 interviews of practitioners in surgery wards from several French institutions. The verbatims issued from interviews were analyzed manually, independently and one by one, by two researchers, following iterative thematic analysis. The hierarchy of codes resulting from the analysis conducted to develop a comprehensive model.

RESULTS

We showed that safety awareness could be enhanced with actions at 3 levels. At technical level, there is a need to develop a suitable digital device, in the form of a professional smartphone with a secured and usable application for both data sharing and storage. The application should provide an instant messaging, allowing the transfer of high and complex data, and be interoperable with both the Electronic Health Record and a datawarehouse. At individual level, health professionals should benefit more education in digital health, including security. At institutional level, hospitals should be more involved by providing regulations, assistance, financial investment and limiting professional’s constraints.

CONCLUSIONS

A global strategy should be adopted to enhance security in data sharing, with new devices integrated in a systemic change.
The Performance of ChatGPT-4V in the Japanese Medical Licensing Exam: Image and Table Insights (Preprint)
Authors: Takagi Soshi , Koda Masahide , Watari Takashi
Published: November 2023

UNSTRUCTURED

The recent introduction of Chat Generative Pre-trained Transformer 4 Vision (ChatGPT-4V) has expanded the capabilities of language models to include image input features, potentially broadening their application in the medical field. This Research Letter evaluates the performance of ChatGPT-4V in interpreting clinical images and tables through the Japanese Medical Licensing Exam (JMLE). Employing the September 25, 2023, version of ChatGPT-4V, the study compared the program's responses to the 117th JMLE against the passing criteria and the average scores of human examinees. While ChatGPT-4V surpassed the passing threshold with an 85.1% correct response rate in essential knowledge and 76.5% in other areas, it fell short in image-based (71.9%) and table-based questions (35.0%), indicating a significant gap compared to human performance. This suggests limitations in the model's image and table interpretation, exacerbated by its lower proficiency in non-Latin characters and potential overreliance on text information. Despite its success in passing the JMLE, the study highlights the need for further development of ChatGPT-4V to enhance its reliability for medical applications, including diagnostics.
Program Pelatihan Pengelolaan Arsip Dalam Mewujudkan Program Tertib Arsip di Pemerintah Kota Batu
Authors: Hendrawan Muhammad Rosyihan , Anggraeni Novita Cristyne
Published: November 2023

Tujuan dari penelitian ini adalah untuk mendeskripsikan dan menganalisis program pelatihan pengelolaan arsip dan faktor pendukung dan penghambat program. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan kualitatif. Pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Analisis data yang digunakan dalam penelitian terdiri dari pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil dari penelitian ini menunjukkan bahwa program pelatihan pengelolaan arsip masih belum berjalan secara maksimal. Hal ini dikarenakan: 1) Sudah ada kesesuaian antara program dengan kelompok sasaran, dikarenakan program tersebut mampu memberikan dampak dan manfaat yang baik bagi kelompok sasaran. 2) Belum ada kesesuaian antara program dengan organisasi pelaksana dikarenakan organisasi pelaksana masih belum dapat memenuhi kebutuhan untuk menjalankan program tersebut. 3) Sudah ada kesesuaian antara kelompok sasaran dan organisasi pelaksana yaitu sudah adanya koordinasi, komunikasi dan kerjasama yang baik antara kelompok sasaran dan organisasi pelaksana. Pemerintah Kota Batu perlu memperhatikan penyediaan dana dan standar operasional prosedur serta sumber daya manusia dalam pelaksanaan program pelatihan pengelolaan arsip di Pemerintah Kota Batu
Sistem Kriptografi pada Pengamanan Autentikasi Dokumen Elektronik: Systematic Literature Review
Authors: Harahap Aisyah Romauli , Salim Tamara Andriani
Published: November 2023

Konsep dari sistem kriptografi pada pengamanan autentikasi dokumen elektronik adalah menjamin keaslian, kerahasiaan, dan keamanan dari dokumen elektronik tersebut. Mengetahui bahwa sistem kriptografi dapat menjaga keamanan yang sangat ketat, karena tidak memungkinkan adanya kejadian penyadapan dan pengubahan data oleh pihak luar yang tidak sah. Digunakannya teknik sistem kriptografi untuk melakukan transfigurasi dan transisi terhadap data yang dihasilkan agar tidak dapat dipahami oleh pihak ketiga dengan cara dibuatnya penyandian enkripsi dan deskripsi, untuk menjamin keaslian, kerahasiaan dan keamanan dokumen elektronik. Artikel ilmiah yang digunakan adalah artikel ilmiah terindeks Scopus (2017-2022), akan dianalisis dengan metode systematic literature review (SLR). Parameter yang dianalisis meliputi beberapa aspek yaitu jumlah artikel yang terbit, seleksi jurnal, penulis artikel ilmiah, institusi penulis, serta asal negara artikel terbit, kolaborasi antar penulis, dan jumlah kutipan yang digunakan. Hasil dari analisis tersebut akan divisualisasikan dengan aplikasi VOSviewer. Ditemukan ada beberapa artikel ilmiah yang dapat diketahui bahwa penulis, institusi, dan negara mana yang melakukan penelitian mengenai penyandian sistem kriptografi untuk pengamanan autentikasi dokumen elektronik. Publikasi mengenai sistem kriptografi pada pengamanan dokumen elektronik cenderung mengalami peningkatan yang signifikan dari tahun 2018-2022.
Effect of Archival-based Content on Instagram Engagement: A Study on @arsipugm
Authors: Prabowo Thoriq Tri , Jannana Nora Saiva , Anjarwati Siwi
Published: November 2023

This studyaims to examine the effect of archival-based content types on Instagram engagement in an archival institution in Indonesia. This is quantitative study. Data were obtained from the Instagram log content included like and comment number, within February 2023 to July 2023. There were 63 contents in that period. The contents were categorized into five categories: (A) greeting to followers; (B) archival material; (C) daily news; (D) promoting the services; and (E) archival knowledge. One-way analysis of variance (ANOVA) was employed to analyze the data. The results revealed that there was a significant difference on “likes” mean score among the content types. On the other hand, content types had no significant effect on “comments” mean score. Implementation of principles of social media optimization is suggested to enhance the Instagram engagement. This study offers an intentional approach for archival institutions to enhance their engagement in social media.
THE POWER OF LOVE AS A TRANSFORMATIVE FORCE: ALAIN BADIOU’S THEORY OF LOVE AND CIVIL RIGHTS MOVEMENT IN THE US
Authors: Syaebani Muhammad Irfan , Yuwono Untung , Ekosiwi Embun Kenyowati
Published: November 2023

Love is never considered as a transformative force. Love is generally perceived merely as an affective-emotional thing and personal relationship. Love does not have any practical implication in transforming society. Through Alain Badiou’s theory of love, it can be demonstrated that love has the power to impact the world. According to Badiou, philosophy is a truth procedure that is always occurring in the arena. Politics, science, art, and love are the arenas in which philosophy operates. Thus, it is possible to talk about love philosophically. Philosophy aims to change the world since love is one of the arenas where philosophy operates. Based on the descriptive analysis method in interpreting Alain Badiou’s works; Being and Event and In Praise of Love, it implies that love can generate a transformative action. The case of miscegenation marriage between Mildred Jetter, an African-Indigenous American, and Richard Loving, a white male, during the civil rights movement in the US, can illustrate the role of love in transforming the world. Alain Badiou’s theory of love explains that love can transcend personal dimensions, and it is not purely a romantic feeling and personal relationship but also a transformative force. Thus, this study brings a new perspective on love theoretically and practically because love is not merely an emotion but also a force for change with social dimensions in practicality.
Impact of E-Learning System: Google Classroom Interaction between E-Facilitators and E-Learners at the University of Ibadan Open Distance Learning Centre, Nigeria
Authors: ADEKUNLE Idowu James
Published: November 2023

Open Distance Education, an e-learning delivery system, is structured toward quality education for development and growth that meets the needs of the modern world. Its e-learning method is geared toward quality education that provokes critical thinking, scientific innovation, artistic revolution, and managerial skills. With all these qualities, criticizers still believe that the orthodox method of learning drills, as such face-to-face interaction, fixed location, and immediate feedback are still the best learning practice. Therefore, this article examines the impact of the e-learning system of Open Distance Education as a friendly learning flexibility and teaching mode that provokes mutual understanding, critical thinking, and immediate feedback between online facilitators and e-learners. Also, it investigates how its teaching approach stimulates innovative research, learning security, and interactive mutuality. Seven (7) excerpts are purposively selected from Google classroom interactions. The article uses Schechner's performance theory and the theories of Freud and Jung. Performance theory emphasizes human activities, while the theories of Freud and Jung talk about human interactive engagements. Theories are used to analyze interactive mutuality and knowledge based-performance between e-facilitators and e-learners. The data are subjected to content analyses.
Filosofía de la Historia Americana
Authors: Zea Leopoldo
Published: November 2023

Los aportes de Lepoldo Zea a la reflexión sobre América y el mundo no deben restringirse al ámbito filosófico propiamente dicho, ya que logró configurar una serie de temas y problemas nodales que a su vez sometió a un amplio debate intelectual. No le bastó con recuperar lo que significó para América Latina la apertura de la corriente de la historia de las ideas y el reconocimiento de la dignidad de la filosofía latinoamericana, sino que tuvo este quehacer, cuyo reconocimiento culmina en obras como Filosofía de la historia americana (1978). Para Zea no se trataba sólo de descubrir un tema, definir un problema o aplicar una metodología para su análisis: se trataba de fundarlo como tal, de enlazarlo con una tradición de pensamiento y de establecer un diálogo con los maestros que lo precedieron y los contemporáneos que lo acompañaron en la magna tarea de pensarnos.
Fault-tolerant quantum computation of molecular observables
Authors: Steudtner Mark , Morley-Short Sam , Pol William , Sim Sukin , Cortes Cristian L. , Loipersberger Matthias , Parrish Robert M. , Degroote Matthias , Moll Nikolaj , Santagati Raffaele , Streif Michael
Published: November 2023

Over the past three decades significant reductions have been made to the cost of estimating ground-state energies of molecular Hamiltonians with quantum computers. However, comparatively little attention has been paid to estimating the expectation values of other observables with respect to said ground states, which is important for many industrial applications. In this work we present a novel expectation value estimation (EVE) quantum algorithm which can be applied to estimate the expectation values of arbitrary observables with respect to any of the system's eigenstates. In particular, we consider two variants of EVE: std-EVE, based on standard quantum phase estimation, and QSP-EVE, which utilizes quantum signal processing (QSP) techniques. We provide rigorous error analysis for both both variants and minimize the number of individual phase factors for QSPEVE. These error analyses enable us to produce constant-factor quantum resource estimates for both std-EVE and QSP-EVE across a variety of molecular systems and observables. For the systems considered, we show that QSP-EVE reduces (Toffoli) gate counts by up to three orders of magnitude and reduces qubit width by up to 25% compared to std-EVE. While estimated resource counts remain far too high for the first generations of fault-tolerant quantum computers, our estimates mark a first of their kind for both the application of expectation value estimation and modern QSP-based techniques.
Covariant catalysis requires correlations and good quantum reference frames degrade little
Authors: Luijk Lauritz van , Werner Reinhard F. , Wilming Henrik
Published: November 2023

Catalysts are quantum systems that open up dynamical pathways between quantum states which are otherwise inaccessible under a given set of operational restrictions while, at the same time, they do not change their quantum state. We here consider the restrictions imposed by symmetries and conservation laws, where any quantum channel has to be covariant with respect to the unitary representation of a symmetry group, and present two results. First, for an exact catalyst to be useful, it has to build up correlations to either the system of interest or the degrees of freedom dilating the given process to covariant unitary dynamics. This explains why catalysts in pure states are useless. Second, if a quantum system ("reference frame") is used to simulate to high precision unitary dynamics (which possibly violates the conservation law) on another system via a global, covariant quantum channel, then this channel can be chosen so that the reference frame is approximately catalytic. In other words, a reference frame that simulates unitary dynamics to high precision degrades only very little.
PERFIL DOS PACIENTES E ATENDIMENTOS REALIZADOS EM UMA UNIDADE BÁSICA DE SAÚDE COM ATENDIMENTO NOTURNO
Authors: De Carvalho Suelen Da Fré , Muller Patrícia Ana , Dexheimer Geórgia Muccillo
Published: November 2023

Introdução: O Sistema Único de Saúde (SUS), criado em 1988, tem como objetivo promover saúde de forma integra e igualitária para toda a população. As unidades básicas de saúde (UBS), caracterizadas como atenção primária, desempenham papel fundamental neste sistema, sendo a principal porta de entrada da população, além de estruturar de forma correta os atendimentos e acompanhamentos que são encaminhados para as demais esferas do SUS. Objetivo: Este trabalho tem por objetivo avaliar o perfil da população atendida em uma UBS Universidade, vinculada a Universidade do Vale do Taquari - Univates, na cidade de Lajeado – RS, com atendimento noturno. Métodos: Foram avaliados os perfis dos pacientes atendidos, utilizando as variáveis: idade, sexo, bairro de origem, turno de atendimento e especialidade médica encaminhada, durante um período de 01 de janeiro a 31 de dezembro de 2019. Resultados: De um total de 6582 consultas e reconsultas, houve uma prevalência de atendimentos do sexo feminino (59%), na faixa dos 25 a 59 anos (60%). O predomínio dos atendimentos foi no turno da noite, para ambos os sexos, e que os bairros de origem mais comuns entre os pacientes atendidos foram: Conventos, com 1167 acessos a UBS, e o Montanha com: 901 acessos. Conclusão: A UBS tem papel fundamental na atenção e promoção da saúde da população. Os atendimentos noturnos se mostram importantes e indispensáveis para propiciar acesso à população, principalmente àqueles com jornada de trabalho diurna.
BOAS PRÁTICAS RELACIONADAS À ASSISTÊNCIA DE ENFERMAGEM DURANTE A ADMINISTRAÇÃO DE MEDICAMENTOS DE ALTA VIGILÂNCIA NA UNIDADE DE TERAPIA INTENSIVA
Authors: Rosa dos Santos Talita , Tonin Luana , Araujo Adriana , Shimbo Adriano
Published: November 2023

Objetivo: Identificar e documentar as boas práticas relacionadas à assistência de enfermagem durante a administração de medicamentos de alta vigilância na Unidade de Terapia Intensiva descritas na literatura científica. Metodologia: Revisão Integrativa da literatura para identificar práticas relacionadas à assistência de enfermagem na administração de medicamentos de alta vigilância. Resultados: Benzodiazepínicos, antipsicóticos, hipnóticos, antidepressivos, opioides, glicose 50%, insulina NPH e regular, heparina e varfarina são os medicamentos de alta vigilância mais utilizados na UTI. Para melhorar o uso destes medicamentos, a literatura destaca a importância de barreiras de prevenção, incluindo cuidados comportamentais e ambientais dos profissionais, como dupla checagem, limitação de interrupções, uso de sinalizações coloridas, entre outros. Considerações finais: São consideradas fundamentais medidas eficazes, como comportamento, ambiente, tecnologia, educação continuada e requalificação para profissionais envolvidos, a fim de fornecer capacitação adequada para uma assistência individualizada e segura.
AVALIAÇÃO DA QUALIDADE DE VIDA DE IDOSOS COM SEQUELAS DE ACIDENTE VASCULAR CEREBRAL: SCOPING REVIEW
Authors: Barreto Pires Santos Lucas , Alves Vilela Alba Benemérita , Silva Santos Jacquelane , Moreira Freire Maria Eliane
Published: November 2023

Mapear os principais instrumentos de avaliação da qualidade de vida de pessoas idosas com sequelas de Acidente Vascular Cerebral. Estudo do tipo revisão de escopo, realizado a partir de artigos extraídos das bases de dados MEDILINE (PubMed) e CINAHL (via EBSCO), em que foram utilizados descritores contemplados nos diretórios DeCS e MeSH, pertinentes à seguinte questão norteadora: Qual o estado da arte divulgado na produção científica nacional e - internacional sobre instrumentos utilizados para medir a qualidade de vida de pessoas idosas que foram acometidas de AVC? Preencheram os critérios de elegibilidade 22 estudos. Os instrumentos genéricos de avaliação da qualidade de vida utilizados foram o EQ-5D, em oito (35%) estudos, o SF-36-- e o RAND-36, em dois (7%) estudos, respectivamente. O IQV, o WHOQOL-BREF e o SF-12 apareceram uma vez (4%) em cada estudo. Em relação aos instrumentos específicos, destacaram-se o SAQOL-39- e o SS-QOL, - em três (14%) estudos, cada; -o NEURO-QOL foi utilizado em dois (9%) estudos. A utilização de instrumentos validos e específicos para medir qualidade de vida de pessoas com doenças graves e suas complicações, possibilita identificar -indicadores e determinantes para orientar a prática assistencial e garantir ao idoso uma melhor qualidade de vida.
QUALIDADE DE VIDA DE MULHERES NO CLIMATÉRIO USUÁRIAS DA ATENÇÃO PRIMÁRIA À SAÚDE
Authors: Santos Jacquelane Silva , Da Costa Aurélio Molina , Pires Santos Lucas Barreto
Published: November 2023

O objetivo deste estudo foi analisar a qualidade de vida de mulheres no climatério usuárias da Atenção Primária à Saúde. Trata-se de uma pesquisa quantitativa, do tipo transversal, realizada com mulheres no climatério. A amostra foi composta por 265 mulheres. Os dados foram coletados utilizando um questionário sociodemográfico e o WHOQOL-Bref. Realizou-se estatística descritiva, medidas de tendência central e dispersão, cálculo da frequência relativa e do teste de Kolmogorov-Smirnov. Quanto às variáveis sociodemográficas, a faixa etária de 61-65 anos, ciclos regulares ou menopausadas, não solteiras, com maior escolaridade e renda familiar, foram as que tiveram melhor qualidade de vida. Em relação à raça autodeclarada, as mulheres pretas apresentaram escores mais baixos em todos os parâmetros investigados com o questionário socioeconômico e demográfico. Dos domínios avaliados no instrumento WHOQOL-Bref, o domínio físico, o social e o psicológico apresentaram melhores resultados para a qualidade de vida satisfatória e o domínio meio ambiente obteve menor contribuição para uma melhor qualidade de vida em todas as facetas investigadas. Conclui-se que, embora a qualidade de vida geral da mulher seja satisfatória, algumas variáveis relacionadas às condições sociais, nível de instrução e condições de moradia que se comunicam com o domínio meio ambiente trazem resultados menos satisfatórios que podem impactar na qualidade de vida das mulheres climatéricas.
Asymmetric Two-component Alkenyl Catellani Reaction for the Construction of C--N Axial Chirality
Authors: Wu Chengui , Liu Ze-Shui , Shang Yong , Liu Chang , Deng Shuang , Cheng Hong-Gang , Cong Hengjiang , Jiao Yinchun , Zhou Qianghui
Published: November 2023

Herein we report an asymmetric two-component alkenyl Catellani reaction
for the construction of C–N axial chirality through a pal-ladium/chiral
norbornene cooperative catalysis and an axial-to-axial chirality
transfer process. Various partially aromatic iodinated 2-pyridones,
quinolones, coumarin and uracil substrates react with 2,6-disubstituted
aryl bromides with a tethered amide group, to afford a wide variety of
polycyclic C–N atropisomers (38 examples, up to 97% e.e.). The
obtained C–N axial chirality is originated from the preformed transient
C–C axial chirality with high fidelity. The synthetic utility of this
chemistry is demonstrated by facile preparation of complex quinoline and
pyridine based C–N atropisomers through a N-deprotection and
aromatization sequence. In addition, a remote axial-to-central
diastereoinduction process dictated by C–N axial chirality is observed
with excellent diastere-ocontrol.
Esthetic assessment of the ornamental forms of northern white cedar (Thuja occidentalis L.) and their use in garden and park compositions
Authors: Kycheryavyj Volodymyr , Popovych Vasyl
Published: November 2023

Northern white cedar (Thuja occidentalis L.) is represented in the world by
about 200 ornamental forms, 43 of which were discovered and described in
landscaping and nurseries of Lviv. The first plantations in Lviv date back
to the 1920s. They were introduced by the professor at the Medical Institute
T. Vilchynskyi, who brought material for cuttings from a nursery in Kurnik
(Poland). The decorative qualities of these cultivars were determined on the
basis of characteristic features and evaluated in points: the shape and
density of the crown, the color of the needles, the nature of branching, and
the features of seed-bearing. These decorative qualities formed the basis
for the construction of various elements of garden and park compositions
with the participation of tapeworms, alleys, green walls, hedges, boskets,
topiaries, and rock gardens. The highest number of points (12) was obtained
by 46.4% of ornamental forms, 11 - 16.3%, 10 - 9.3%, and 8 -11.6%. Cultivars
with a distinct regular crown shape received high evaluation points. The
options for the spatial arrangement of individuals were proposed and the
distance between seating positions was recommended. Taking into account the
high plasticity of cultivars and the ability to form crowns, variants of
clipped hedges and topiaries were recommended. Several models have been
proposed based on the distribution of ornamental plant groups based on their
symmetry, silhouettes, alignments, contrasts, colors, density, and sizes.
Cultivars were selected for each variant, and their group arrangement was
proposed.
Serbian black truffle Tuber aestivum: Microbiota and effects of different freezing regimes on volatile aroma compounds during storage
Authors: Paunovic Dusanka , Mirkovic Milica , Mirkovic Nemanja , Tesevic Vele , Stankovic-Jeremic Jovana , Todosijevic Marina , Radulovic Zorica
Published: November 2023

The use of truffles in food is based mainly on the addition of artificial
flavors, aiming to achieve an intense aroma in the products. As truffle is a
natural product with nutritional and functional properties, it is important
to find an optimal method for truffle storage. As the microbiota contribute
to truffle aroma, the bacterial and yeast compositions in the rhizosphere
and fruiting body of the truffle and the impact of different freezing
methods on the volatile profile of the truffle Tuber aestivum during 90 days
of the storage were determined. Bacteria and yeasts isolates were identified
using 16s rRNA and 18s rRNA. The effect of freezing truffles at -20?C and
-80?C with and without previous dipping in liquid N2 on the volatile
compounds was observed using GC/MS. The results demonstrated that the
isolated bacteria belonged to the phylum Proteobacteria, Firmicutes and
Actinobacteria, and the identified species mainly belonged to Firmicutes,
genus Bacillus sp. Isolated yeasts were identified as Cryptococcus sp.,
Debaromyces hanseinii, Candida fermentati and Rhodotorula mucilaginosa. The
GC/MS analysis revealed that frozen truffle samples were richer in the
compounds 2-butanone, 2-methyl-butanal, methanethiol and 2-butanol after
freezing or during storage. The content of DMS, acetaldehyde, 3-octanone,
ethanol, and 2-methyl-1-propanol significantly decreased immediately after
freezing. Overall, the gained results indicated that freezing of truffles as
a preservation method had profound effects on the volatile compounds, while
previous dipping in liquid N2 showed no significant impact on the volatile
profile of truffle Tuber aestivum.
Existent state and removal rate of silver in lead-silver slag during the melt-vaporization process
Authors: Shen Y.-Y. , Zhao X.-S. , Zhang F.-J. , Ma W.-X. , Wang X.-F. , Du X.-Y.
Published: November 2023

In this paper, Ag contained in the lead-silver slag was recovered during the melt-vaporization process. The existing Ag state in the soot was analyzed, the influence of the reaction temperature, the carbon ratio, and the reaction time on the removal rate of the silver was investigated, and the process conditions were optimized using reaction surface methodology. Silver chloride, silver metal, silver sulfide, silver oxide, and silver sulfate are the main silver phases in lead-silver slag, of which silver chloride and silver sulfide are the main phases. The silver oxide (Ag2O) and the silver chloride (AgCl) in the leadsilver slag volatilize to soot, the silver sulfide (Ag2S) is oxidized by oxygen to silver sulfate (Ag2SO4), and elemental silver volatilizes with Pb and Zn to form alloys. The silver is ultimately present as Ag, AgCl, Ag2O and Ag2SO4 in the soot. The removal rate of the silver gradually increases with increasing reaction temperature and tends to remain stable at 1300?C. With a gradual increase in the carbon content, the removal rate of silver first increases and then decreases. The highest value is 80.12 wt% when the carbon content is 16.30 wt%. As the holding time increases, the silver removal rate gradually increases and then stabilizes at 79.97 wt% even at a holding time of 150 minutes. The optimum process conditions for silver removal are a reaction temperature of 1340?C, a carbon content of 16.10 wt%, and a holding time of 165 minutes. The average removal rate of silver under these conditions is 80.42 wt%. The research in this article provides a theoretical basis for the removal and utilization of silver from lead and silver residues.
ADMET profiles of selected anabolic steroid derivatives
Authors: Bitang Andrei , Bitang Viorel , Grosu Vlad , Ciorsac Alecu , Isvoran Adriana
Published: November 2023

There is control over steroids use and marketing, but also new compounds that mimic their effects, steroid derivatives, are being synthesized. They are frequently produced as dietary supplements intended to improve physical activity, and usually no information is provided regarding their composition, dosages, and efficacy or safety. In this study, a computational approach was used to evaluate the absorption, distribution, metabolism, excretion and toxicity (ADMET) profiles of several steroid derivatives: methasterone, methyl-1-testosterone, 4-hydroxytestosterone, methyldienolone, methyltrienolone and 19-nor-5-androstenedione. The following computational prediction tools were applied: admetSAR2.0, ADMETLab2.0, Endocrine Disruptome, PredSkin3.0. All investigated compounds showed good human intestinal absorption, are not able to penetrate the blood-brain barrier and inhibit cytochrome P450 enzymes involved in the metabolism of xenobiotics. These compounds have potential for skin sensitisation, induce reproductive toxicity and endocrine disruption, and have a low potential for hepatotoxicity and respiratory toxicity. It is important that the results of the study are known by those exposed at workplaces where these compounds are produced and packed as well as by consumers. These predictions can also guide the experimental evaluation of the possible toxicity of the investigated compounds, the results of which can be further used for purposes of regulating the use of these steroid derivatives.
Investigation on the influence of the MWCNT, Al2O3 and CuO nanofluid in the ETSC
Authors: Kumar Konka , Ramya Ganesan , Ambikeswari Narayanasamy , Ravishankar Sathyamurthy , Venugopal Jayaprakash , Surakasi Raviteja , Tamilarasan Uthirapathy , Sathish T. , Vijayan V.
Published: November 2023

In this experimental work is based on the comparison on the three different nanoparticle mixed nanofluid usage influence on the evacuated tube solar collector (ETSC). The distilled water is initially tested to identify the better performance providing mass-flow rate then the mass-flow rate. There are three nanoparticles such as MWCNT, Al2O3, and CuO were used in to create the nanofluid by two step method to use as a heat transfer fluid in the system. There are four different combinations of nanofluid were created based on the 0.05% of volume fraction of nanoparticles involvement. The corresponding performance parameters such as outlet temperature, maximum absorbed heat and thermal efficiency were measured and calculated. Among that 50% of MWCNT, 40% of Al2O3, and 10% of CuO nanoparticle mixer of 0.05% volume fraction used nanofluid reached the 38.76% higher temperature difference 33.02% more useful heat absorbed and 33.04% of more efficiency than distilled water in the system.
Kinetic characterization of low velocity positive collision of double droplets
Authors: Ma Zhiheng , Sun Jinjuan , Tian Jianhui , Qu Jinxiu
Published: November 2023

Droplet positive collision is a complex process involving heat transfer in gas-liquid-solid three-phase flow and droplet collide dynamics. In order to study the kinetic behavior of droplets under positive collision in low velocity (v < 2 m/s), this paper focuses on the spreading, vibration, and fracture characteristics of double droplets by numerical simulation. First, the accuracy of the model is verified by experimental comparison. The effects of droplet diameters, collision velocities and wall contact angles on the spreading process are analyzed, and the spreading factor curves are plotted. Then, the droplet rebound vibration after collision fusion is equated to a single-degree-of-freedom damped vibration system, and the peak vibration height variation curve of the fused droplet is obtained by non-linear fitting. Considering the droplet phase change, the influence law of different conditions on the vibration damping factor and vibration time of the fused droplet is studied. Finally, it is found that rebound fracture and spreading fracture occur after the fusion of double droplets under positive collision, and the critical values of collide velocity required for the occurrence of the aforementioned phenomenon are found. To provide a reliable theoretical basis for the study of heat and mass transfer processes after multiple droplets collide the wall.
Experimental study of acoustic streaming induced by a sharp edge at different frequencies and vibrating amplitudes
Authors: Chen Hui , Zhong Geyu , Zhang Chuanyu , Liu Dan , Wei Xueyong , Liu Yingwen
Published: November 2023

Acoustic streaming is the time-averaged flow induced by acoustic waves inside the fluid medium. Much attention has been paid to the streaming flow at the microscale, with the rapid development of micro-fluidics and significant demand for the microscale manipulation of fluid or particles. Recently, the streaming flow at the audible or lower frequency (10 Hz~10 kHz) has been found to be closely associated with local structures, like a sharp edge in the micro-channel. By its strong magnitude and low cost, this kind of streaming flow has been applied in various fields. However, the mechanisms behind this non-classical Rayleigh streaming are still not very clear, though its high sensitivity to the thickness of the acoustic boundary-layer and unstable streaming pattern under high forcing amplitude have been demonstrated. In this study, experimental work has been conducted, with the help of the particle imaginary velocimetry platform, to reveal the influence of frequency and vibrating amplitude on the streaming flow field around a sharp edge with 90?, and its characterized spatial dimension. The scaling law concerning the vibration amplitude and streaming velocity has been come up with, and the parameter frequency is also included. The expression f ?1/6va2~vsy,max demonstrates a good prediction in terms of the streaming magnitude, in comparison with experimental results.
Chemical and thermodynamic properties of Bombyx mori (domestic silk moth): Empirical formula, driving force, and biosynthesis, catabolism and metabolism reactions
Authors: Popovic Marko , Pantovic-Pavlovic Marijana , Sekularac Gavrilo
Published: November 2023

Biothermodynamics is a discipline which has developed intensely during the last 50 years. Thermodynamic properties have been reported for humans, animals, plants, and microorganisms. However, this paper reports for the first time the empirical formula and thermodynamic properties for insects. Thermodynamic properties can be applied in research on thermodynamic interactions between organisms and their environment, as well as between organisms themselves. This paper reports for the first time the empirical formula and reactions of catabolism, biosynthesis and entire metabolism for Bombyx mori (domestic silk moth), as well as the thermodynamic properties of Bombyx mori. It is shown that growth of Bombyx mori is tightly related to catabolism of carbohydrates and lipids, which represents the driving force for the entire metabolism.
Enhancement of Coating Features by Supporting Zinc-Based Coating with Cataphoresis Process: Effect of Acidity and Coating Thickness on the Coating Quality
Authors: Yargıç Adife Şeyda , Eren Bünyamin , Özbay Nurgül
Published: November 2023

In this work, two hot-forged cast materials that are often used in the automobile sector were employed to produce cast elements with enhanced corrosion performance at low microns by combining two forms of cost-effective coatings (zinc + cataphoresis). In the context of the investigation, firstly 5-8 µm or 12-15 µm zinc-coating in an alkaline (Zn, Zn-Fe, Zn-Ni) or an acidic (Zn, Zn-Ni) environment, followed by 20-25 µm cataphoresis-coating were performed on GGG40 cast-parts. Ink, hogabom, shock, pull-off adhesion, water resistance, salt spray, stone impact, cyclic-corrosion, and scab-corrosion performance tests were implemented for characterization. In addition, the zinc-coating thickness and the phosphate-crystal appearance were evaluated in the x-ray diffraction laminography instrument and the scanning electron microscope. The tensile strengths were determined by the pull-off adhesion test between 171 and 433 psi. The coating thicknesses of zinc-coated parts in alkaline and acidic environments were assigned in the range of 5.88-7.18 µm and 12.10-12.96 µm. Due to the characterization results; it was deduced that the cataphoresis-coating after all zinc-based-coatings under alkaline medium did not afford the required quality and corrosion protection, while cast parts coated under acidic medium before cataphoresis-coating gave appropriate corrosion performance, thus the low-cost coatings could be performed with the eligible properties.
Behind the Veil of Blue Ecolabelling: Dismantling the Juxtaposition of International Regulations on Sustainable Oceans
Authors: Woods Jonathan , Meliala Aurora Jillena
Published: November 2023

Ecolabelling was introduced as an alternative consumer-facing mechanism in the market to combat certain threats against the environment and to promote sustainable usage of its components. More importantly in the case of Indonesia as a maritime country, fishery ecolabels can be used to build sustainability to its marine environment which can be vital for its economy in the future. To this end, this article constructs an exposition of ecolabels from a legal perspective in the international and local contexts that is still absent in Indonesia’s legal research. This study employs normative legal research methodology in its data collecting and analysis. The article in its analysis will argue that while the international standards provided for blue ecolabels are robust, its genuine implementation can only be realized in the domestic scene, where local aspects can be considered. This research in the end finds that an ecolabelling of fisheries in Indonesia is urgently needed, concludes that ecolabelling in fisheries can help the state in realizing its international commitments, and recommends its urgent creation in the national scene.
Application of frequency stability criterion for analysis of dynamic systems with characteristic polynomials formed in j1/3 basis
Authors:   Lviv Polytechnic National University, Lozynskyy Orest , Marushchak Yaroslav ,   Rzeszow Univesity of Technology, Lozynskyy Andriy ,   Lviv Polytechnic National University, Kopchak Bohdan ,   Lviv Polytechnic National University, Kasha Lidiya ,   Lviv Polytechnic National University
Published: November 2023

This paper considers the stability of dynamical systems described by differential equations with fractional derivatives. In contrast to a number of works, where the differential equation describing the system may have a set of different values ​​of fractional derivatives, and the characteristic polynomial is formed on the basis of the least common multiple for the denominators of these indicators, this article proposes forming such a polynomial in a specific j¹/³ basis and studying the stability of systems with such fractional description based on the resulting rotation angles of Hn(jl/mω) vector at a frequency change from zero to infinity. This technique is similar to the investigation of system stability by frequency criteria used for a similar problem in describing the system by differential equations in integer derivatives. The application of characteristic polynomials formed in the j¹/³ basis for the description of the processes in dynamic systems and the analysis of the stability of such systems on the basis of the frequency criterion are the essence of the scientific novelty of this paper. The article contains the following sections: problem statement, work purpose, presentation of the research material, conclusions, list of references.