bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: One‐Pot Synthesis of Three Types of 2,3‐Disubstituted Thienopyridines from Halopyridinyl Ketones.
Authors: Kobayashi Kazuhiro , Kozuki Taketoshi , Konishi Hisatoshi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bifunctional Organocatalyst to Promote the Biginelli Reaction under Mild Conditions.
Authors: Mase Nobuyuki , Nakamura Daisuke , Kawano Yasuhiro , Suzuki Yuka , Takabe Kunihiko
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Investigation into the Reaction of 2‐Amino‐4,5‐dimethylthiophene‐3‐carboxamide with Iso(and Isothio)cyanates under Microwave Irradiation.
Authors: Davoodnia Abolghasem , Rahimizadeh Mohammad , Atapour‐Mashhad Hoda , Tavakoli‐Hoseini Niloofar
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hit to Lead Optimization of Pyrazolo[1,5‐a]pyrimidines as B‐Raf Kinase Inhibitors.
Authors: Gopalsamy Ariamala , et al. et al.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Autocatalysts Show Organocatalysis of Other Reactions.
Authors: Kamioka Seiji , Ajami Dariush , Rebek Julius Jr.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereochemistry of Disilanylene‐Containing Cyclic Compounds — Synthesis and Palladium‐Catalyzed Reactions of cis‐ and trans‐3,4‐Benzo‐1,2‐diisopropyl‐1,2‐dimethyl‐1,2‐disilacyclobut‐3‐ene.
Authors: Naka Akinobu , Sakata Jun , Ikadai Junnai , Kawasaki Hiroyuki , Ohshita Joji , Miyazaki Eigo , Kunai Atsutaka , Yoshizawa Kazunari , Ishikawa Mitsuo
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Friedlaender Reaction in the Synthesis of 2‐(Phosphoryl)alkyl‐Substituted 1,6‐Naphthyridines.
Authors: Lemport Pavel S. , Bodrin Georgy V. , Belyakov Andrey I. , Petrovskii Pavel V. , Vologzhanina Anna V. , Nifant'ev Edward E.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorescent Dyes with 2‐Amino‐4,7‐diazaindole Skeleton: Synthesis and Spectroscopy.
Authors: Gryko Daniel T. , Piechowska Joanna , Vetokhina Volha , Wojcik Dominik
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diterpene Esters and Phenolic Compounds from Sapium insigne (Royle) Benth. ex Hook. fil.
Authors: Devkota Hari Prasad , Basnet Purusotam , Yahara Shoji
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Heterosteroids. First Synthesis of Oxa Steroid from Cholic Acid.
Authors: Ibrahim‐Ouali Malika , Botsi‐Nkomendi Nicaise , Rocheblave Luc
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lipase‐Catalyzed Regio‐ and Stereoselective Deacylation: Separation of Anomers of Peracylated α,β‐D‐Ribofuranosides.
Authors: Sharma Raman K. , Aggarwal Neha , Arya Anu , Olsen Carl E. , Parmar Virinder S. , Prasad Ashok K.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoenzymatic Synthesis of GD3 Oligosaccharides and Other Disialyl Glycans Containing Natural and Non‐Natural Sialic Acids.
Authors: Yu Hai , Cheng Jiansong , Ding Li , Khedri Zahra , Chen Yi , Chin Sharlene , Lau Kam , Tiwari Vinod Kumar , Chen Xi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure, Biological Activity, and a Biomimetic Partial Synthesis of the Lirofolines, Novel Pentacyclic Indole Alkaloids from Tabernaemontana.
Authors: Low Yun‐Yee , Lim Kuan‐Hon , Choo Yeun‐Mun , Pang Huey‐Shen , Etoh Tadahiro , Hayashi Masahiko , Komiyama Kanki , Kam Toh‐Seok
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Daphhimalenine A, a New Alkaloid with an Unprecedented Skeleton, from Daphniphyllum himalense.
Authors: Zhang Yu , Di Ying‐Tong , Zhang Qiang , Mu Shu‐Zhen , Tan Cheng‐Jian , Fang Xin , He Hong‐Ping , Li Shun‐Lin , Hao Xiao‐Jiang
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Iridoid Alkaloid from the Flowers of Plumeria rubra L. cv. acutifolia.
Authors: Ye Guan , Li Zhi‐Xiong , Xia Guang‐Xin , Peng Hua , Sun Zhao‐Lin , Huang Cheng‐Gang
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cowaxanthone F, a New Tetraoxygenated Xanthone, and Other Antiinflammatory and Antioxidant Compounds from Garcinia cowa.
Authors: Panthong Kanda , Hutadilok‐Towatana Nongporn , Panthong Ampai
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isolation of Acridone Alkaloids and N‐[(4‐Monoterpenyloxy)phenylethyl]‐Substituted Sulfur‐Containing Propanamide Derivatives from Glycosmis parva and Their Antiherpes Simplex Virus Activity.
Authors: Chansriniyom Chaisak , Ruangrungsi Nijsiri , Lipipun Vimolmas , Kumamoto Takuya , Ishikawa Tsutomu
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Exfoliation of Layered Europium Hydroxide into Unilamellar Nanosheets.
Authors: Hu Linfeng , Ma Renzhi , Ozawa Tadashi C. , Sasaki Takayoshi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 9‐Anilinoacridine Triazines as New Class of Hybrid Antimalarial Agents.
Authors: Kumar Ashok , Srivastava Kumkum , Kumar S. Raja , Puri S. K. , Chauhan Prem M. S.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design, Synthesis and Biological Evaluation of Hydroxy‐ or Methoxy‐Substituted Phenylmethylenethiosemicarbazones as Tyrosinase Inhibitors.
Authors: Yi Wei , Cao Ri‐Hui , Chen Zhi‐Yong , Yu Liang , Ma Lin , Song Hua‐Can
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microstructure and Magnetic Properties of Mo Containing Nanoperm‐type Alloys
Authors: Conde C. F. , Conde A.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polymer‐Assisted Composites of Trimetallic Nanoparticles with a Three‐Layered Core‐Shell Structure for Catalyses
Authors: Toshima Naoki
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Crystal Chemistry of Alkali‐, Alkaline‐Earth‐ and Rare Earth‐Oxozincates
Authors: Mueller‐Buschbaum Hanskarl
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Composite Materials with Ionic Conductivity: From Inorganic Composites to Hybrid Membranes
Authors: Yaroslavtsev A. B.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Determination of Electronic Properties of Manganese Complexes: The Efficient Combination of High Field EPR Spectroscopy and Theoretical Calculations
Authors: Duboc Carole , Collomb Marie‐Noelle
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hybrid Systems Engineering: Polymer‐Peptide Conjugates
Authors: Fee Conan J.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recombinant Production of Self‐Assembling Peptides
Authors: McPherson Michael J. , James Kier , Kyle Stuart , Parsons Stephen , Riley Jessica
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Progress in the Total Synthesis of Indole Alkaloids
Authors: Edwankar Chitra R. , Edwankar Rahul V. , Namjoshi Ojas A. , Rallapalli Sundari K. , Yang Jie , Cook James M.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Reactions with Ring‐Strained Organosilanes
Authors: Larson Gerald L.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: ESR Imaging of Conduction Electrons in Organic Conductors
Authors: Dormann Elmar , Feintuch Akiva , Kaplan Noam
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design and Synthesis of 2′‐Functionalized Oligonucleotides. Their Application for Covalent Trapping the Protein—DNA Complexes
Authors: Dolinnaya Nina G. , Zubin Eugeny M. , Kubareva Elena A. , Zatsepin Timofey S. , Oretskaya Tatiana S.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Substituted Piperazines
Authors: Quirion Jean‐Charles
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tactics in Total Synthesis of (‐)‐Kendomycin
Authors: Shan Mingde , Wang Leo , Zhang Qi , O'Dooherty George A.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Voltammetry in Room Temperature Ionic Liquids: Comparisons and Contrasts with Conventional Electrochemical Solvents
Authors: Barrosse‐Antle L. E. , Bond A. M. , Compton R. G. , O'Mahony A. M. , Rogers E. I. , Silvester D. S.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Evolution of Aromatic Prenyltransferases in the Biosynthesis of Indole Derivatives.
Authors: Li Shu‐Ming
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Large π‐Aromatic Molecules as Potential Sensitizers for Highly Efficient Dye‐Sensitized Solar Cells
Authors: Imahori Hiroshi , Umeyama Tomokazu , Ito Seigo
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Resonance Imaging of Cells in Experimental Disease Models
Authors: Muja Naser , Bulte Jeff W. M.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Expression of Chirality in Physisorbed Monolayers Observed by Scanning Tunneling Microscopy
Authors: de Feyter Steven , Iavicoli Patrizia , Xu Hong
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Einsatz von Magnetfiltern in der Bioverfahrenstechnik – Teil 2: Trennung von Biomasse und Magnetbeads im Magnetfilter
Authors: Kampeis P. , König S. , Schumann C.
Published: March 2010

Die Hochgradienten‐Magnetseparation (HGMS) besitzt großes Potenzial, um als erster Capture‐Schritt in Aufbereitungsverfahren für biotechnologische Produkte eingesetzt zu werden, da sie eine Fest/Fest/Flüssig‐Trennung in einem Schritt ermöglicht. Bei Magnetseparatoren, die nach diesem Prinzip arbeiten, wurde bisher der Tatsache nicht genügend Rechnung getragen, dass die Anlagerungsbereiche der magnetischen Mikrosorbentien, die sich während der Magnetfiltration in der Filtermatrix ausbilden, den freien Strömungsquerschnitt des Magnetfilters einengen und Zellen oder Zelltrümmer zurückhalten oder sogar einschließen können. Schwerpunkt der hier dargestellten Untersuchungen am Umwelt‐Campus Birkenfeld ist daher die Quantifizierung der Trennung von Biomasse (fluoreszierende Escherichia coli‐Zellen) und Magnetbeads in einem HGMS‐Filter. Dazu musste eine geeignete Analysemethode entwickelt werden, die eine Quantifizierung ermöglicht und mit der eine Aussage darüber getroffen werden kann, welche Menge an Bakterienzellen im Filtrat zu finden ist und welche Menge durch die entstehenden Magnetpartikel‐Anlagerungsbereiche an der Filtermatrix zurückgehalten wird. In den Untersuchungen wurden zwei verschiedene Varianten der Filtermatrix getestet und miteinander verglichen. Es wurde in beiden Fällen eine gute Trennung von Biomasse und Magnetbeads – sowohl in Modellsuspensionen als auch in E. coli‐Fermentationsbrühen – erreicht.
Inline‐Partikelgrößenmesstechniken für Suspensionen und Emulsionen
Authors: Hass R. , Munzke D. , Reich O.
Published: March 2010

Die Inline‐Bestimmung von Teilchengrößen in Emulsionen und Suspensionen stellt besondere Anforderungen an die Messtechnik, da auch bei sehr hohen Teilchenkonzentrationen im Prozess verdünnungsfreie Analytik betrieben werden soll. Neben einer Klärung der Begriffe atline, online und in‐line gibt der Beitrag eine Einführung in die mathematische Beschreibung von Größenverteilungen. Als Inline‐Techniken werden Photonendichtewellen‐Spektroskopie, Focused Beam Reflectance Measurement und Ultraschallextinktion‐Spektroskopie diskutiert und ihre sehr unterschiedlichen physikalischen Messprinzipien erläutert. Auch wird kurz erklärt, wie Teilchengrößen aus den Messresultaten erhalten werden. Die wesentlichen Charakteristika dieser drei Methoden werden abschließend im Überblick dargestellt.
Adsorptive Entfernung von Wasser aus primären Alkoholen im ppm‐Bereich
Authors: Bathen D. , Pahl C. , Pasel C. , Luckas M. , Bathen D.
Published: March 2010

Hochreine organische Lösungsmittel gewinnen in der Optik‐, Elektronik‐, Pharma‐ und Chemie‐Industrie zunehmend an Bedeutung. Ein besonders schwieriges Problem stellt die Entfernung von Wasser im unteren ppm‐ und ppb‐Bereich dar. Verfahrenstechnisch lösen lässt sich dieses Problem durch Adsorption des Wassers an Zeolithen, Silicagelen oder Aluminiumoxiden. Obwohl bereits vereinzelt technische Lösungen existieren, fehlen systematische Untersuchungen der Einfluss‐Parameter sowie eine verlässliche Messtechnik. Eine bedeutende Stoffgruppe, die häufig mit sehr niedrigen Wassergehalten benötigt wird, sind die linearen primären Alkohole. Daher wurde das Adsorptionsverhalten der Alkohole von Methanol bis 1‐Hexanol systematisch untersucht. Dabei zeigt sich, dass von den sechs untersuchten Adsorbentien mit 3 Å Molekularsieben die geringsten Restfeuchtegehalte erzielt werden. Die im Konzentrationsbereich bis 1000 ppm vermessenen Adsorptionsisothermen können mit der Langmuir‐Gleichung gut angepasst werden. Dabei zeigen sich deutliche Unterschiede für die Wasserentfernung aus Methanol bis Propanol, während die Isothermen für Butanol bis Hexanol nahezu deckungsgleich sind. Die hierfür verantwortlichen Wechselwirkungen zwischen (kritischen) Moleküldurchmessern und Porengeometrie des Zeoliths einerseits und zwischen Lösungsmittel und Wasser andererseits werden im Detail analysiert.
Recent Progress in the Crystallographic Studies of Photosystem II
Authors: Guskov Albert , Gabdulkhakov Azat , Broser Matthias , Glöckner Carina , Hellmich Julia , Kern Jan , Frank Joachim , Müh Frank , Saenger Wolfram , Zouni Athina
Published: March 2010

The photosynthetic oxygen‐evolving photosystem II (PSII) is the only known biochemical system that is able to oxidize water molecules and thereby generates almost all oxygen in the Earth’s atmosphere. The elucidation of the structural and mechanistic aspects of PSII keeps scientists all over the world engaged since several decades. In this Minireview, we outline the progress in understanding PSII based on the most recent crystal structure at 2.9 Å resolution. A likely position of the chloride ion, which is known to be required for the fast turnover of water oxidation, could be determined in native PSII and is compared with work on bromide and iodide substituted PSII. Moreover, eleven new integral lipids could be assigned, emphasizing the importance of lipids for the perfect function of PSII. A third plastoquinone molecule (QC) and a second quinone transfer channel are revealed, making it possible to consider different mechanisms for the exchange of plastoquinone/plastoquinol molecules. In addition, possible transport channels for water, dioxygen and protons are identified.
Evolution of the Channelrhodopsin Photocycle Model
Authors: Stehfest Katja , Hegemann Peter
Published: March 2010

Many processes in green algae are under control of rhodopsin‐type photoreceptors, but only a few have been studied at least in some detail in the past. Up to now, functionally and biochemically only the channelrhodpsins ChR1 and ChR2 are characterized. Thus, this short review reports on channelrhodopsin properties with a strong focus on the knowledge about the photoreaction cycle(s).
On the Compatibility Criteria for Protein Encapsulation inside Mesoporous Materials
Authors: Giussani Lara , Fois Ettore , Gianotti Enrica , Tabacchi Gloria , Gamba Aldo , Coluccia Salvatore
Published: March 2010

The properties of the enzyme pepsin, relevant to its incorporation inside the channels of mesoporous silica materials in the preparation of bioinorganic hybrids, are highlighted by molecular dynamics simulations of aqueous solutions of the protein under conditions optimal for encapsulation in SBA‐15. The protein size, shape, flexibility and surface properties are calculated with the aim of deriving general accessibility/compatibility criteria favouring encapsulation inside mesoporous systems.
Be careful what you strive for: the significance of motive–goal congruence for depressivity
Authors: Pueschel Oliver , Schulte Dietmar , Michalak Johannes
Published: March 2010

In a sample of 61 psychotherapy outpatients, the current study investigated the association between progress at motive‐congruent personal goals and depressivity. In a correlational design, motives were measured with a Picture Story Exercise. Personal goals and goal progress were assessed using a self‐report approach. The Beck Depression Inventory was used to determine patients' levels of depressive symptoms. In accordance with Beck's congruency hypothesis, results showed that only motive‐congruent goal progress was related to depressivity. Motive‐incongruent progress could not account for interindividual differences in depressive symptoms. Implications of the findings are discussed in terms of the aetiology of depression and the definition of explicit treatment goals. Copyright © 2010 John Wiley & Sons, Ltd.

Key Practitioner Message:

• Goal progress per se is not associated with lower levels of depressivity.

• Only in combination with implicit motives can goal progress account for interindividual differences in depressivity.

• Implicit motives can provide clinicians with important information for the definition of adequate treatment goals.
The value of E‐cadherin/ β‐catenin expression in imprints of NCSLC: Relationship with clinicopathological factors
Authors: Pagaki Eumorfia , Patsouris Efstratios , Gonidi Maria , Athanassiadou Anna‐Maria , Maurikakis Myron , Athanassiades Peter , Chelidonis George , Athanassiadou Pauline
Published: March 2010

Metastasis is specific for malignant tumors and its control is one of the most important problems in the design of therapies for cancer patients. Loss or reduction of E‐cadherin expression and/or β‐catenin expression plays a casual role in tumor progression and metastasis and is associated with poor prognosis.

The purpose of the study is to investigate the expression of E‐cadherin and β‐catenin and their significance as independent prognostic markers in imprints of resected nonsmall cell lung cancer (NSCLC).

Imprint smears from 70 patients who underwent surgical lung resection for primary carcinoma were studied. As control group was used imprints of physiological tissues.

Histologically 47 (67.1%) of the tumors were squamous cell carcinomas and 23 (32.9%) were adenocarcinomas. Tumors stage was I in 29 (41.4%), II in 13 (18.6%), III in 24 (34.3%) and IV in 4 (5.7%).

Positive expression for E‐cadherin was observed in 44.29% of malignant smears vs 85.71% for control group (P = 0.011). For β‐catenin, positive expression was observed in 42.86% malignant cases vs 85.71% for control group (P = 0.008). Positive expression of E‐cadherin and β‐catenin was observed in moderate and well differentiated tumors (P < 0.0001 for both respectively). Positive E‐cadherin and β‐catenin expression was observed in 70.6% and 76.5% of the cases with negative lymphnode metastasis (P < 0.0001 for both respectively). There was no statistically significant association between histological type, tumor stage, pleural invasion, tumor size (P > 0.05 for all) and E‐cadherin/β‐catenin expression.

Reduced E‐cadherin or β‐catenin negative expression relates to dedifferentiation and progression of NSCLC. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Cytodiagnosis of secretory carcinoma of the breast: A report on two cases
Authors: Jena Madhusmita , Shariff Shameem
Published: March 2010

Secretory carcinoma of the breast is a rare (<1%) low grade breast carcinoma which shows distinct features at histology. Diagnosis of this carcinoma at fine needle aspiration cytology (FNAC) is difficult. Two cases of secretory carcinoma of the breast presenting as a breast mass, one in a 24‐year‐old female and the other in a 40‐year‐old female are reported, highlighting their appearance at FNAC. In both the cases the aspirates were cellular and consisted of clusters and single cells with uniform round nuclei showing minimal nuclear atypia. Most of the cells had moderate to abundant cytoplasm with prominent intracytoplasmic vacuoles. Many cells showed a plasmacytoid appearance and others were binucleate. A typical amphophilic bubbly cytoplasm of the tumor cells was observed. Both cases were confirmed as secretory carcinoma on histology. The differences in cell morphology at FNAC of secretory carcinoma of the breast from other breast carcinomas, and its utility of making a preoperative diagnosis are discussed. Diagn. Cytopathol. 2010;38:921–924. © 2010 Wiley‐Liss, Inc.
A case of papillary carcinoma in a thyroglossal cyst without a carcinoma in the thyroid gland
Authors: Albayrak Yavuz , Albayrak Fatih , Kaya Zülküf , Kabalar Esref , Aylu Belkiz
Published: March 2010

The thyroglossal duct cyst is the most common developmental anomaly of the thyroid gland. We present a patient with a papillary thyroid carcinoma diagnosed after surgical resection of a thyroglossal cyst. The 39‐year‐old patient reported to our hospital due to a swelling of this throat. The results of the ultrasonography were reported as showing multiple nodules in both thyroid lobes, and an ∼3‐cm diameter image in the submental area, in keeping with lymphadenomegalia. In the fine‐needle aspiration cytology (FNAC) evaluation from the nodules in the thyroid, it was observed that the thyrocites with uniform nuclei made up single‐layer groups. FNAC from the thyroglossal cyst, a few histiocytes were observed on a ground with a large number of erythrocytes. The patient was subjected to a total thyroidectomy, pyramidal lobe excision, and total excision of the 3‐cm diameter soft mass, starting at the tip of the pyramidal lobe. The case was diagnosed as papillary thyroid carcinoma in thyroglossal duct cyst with histopathological and immunohistochemical findings. If the thyroglossal channel cyst had been diagnosed preoperatively, total thyroidectomy and a Sistrunk operation would have been performed. For this reason, repeated FNAC, particularly, if performed under ultrasound guidance, may improve the diagnostic value of FNAC. Thus, in such patients, throat ultrasonography must be carried out in expert hands, thin‐needle aspiration biopsy, computerized tomography, and thyroid scintigraphy must be done if necessary, and the necessary treatment protocols carried out after a definite diagnosis. Diagn. Cytopathol. 2011;39:38–41. © 2010 Wiley‐Liss, Inc.
Generation of mice with a conditional null allele of the Jagged2 gene
Authors: Xu Jingxia , Krebs Luke T. , Gridley Thomas
Published: March 2010

The Notch signaling pathway is an evolutionarily‐conserved intercellular signaling mechanism, and mutations in its components disrupt embryonic development in many organisms and cause inherited diseases in humans. The Jagged2 (Jag2) gene, which encodes a ligand for Notch pathway receptors, is required for craniofacial, limb, and T cell development. Mice homozygous for a Jag2 null allele die at birth from cleft palate, precluding study of Jag2 function in postnatal and adult mice. We have generated a Jag2 conditional null allele by flanking the first two exons of the Jag2 gene with loxP sites. Cre‐mediated deletion of the Jag2flox allele generates the Jag2del2 allele, which behaves genetically as a Jag2 null allele. This Jag2 conditional null allele will enable investigation of Jag2 function in a variety of tissue‐specific contexts. genesis 48:390–393, 2010. © 2010 Wiley‐Liss, Inc.
Effect of deposition temperature on the properties of thin polymer films deposited by plasma‐enhanced CVD using cyclo‐hexa‐hydrocarbons as monomers
Authors: Moriki Kazunori , Satoh Tetsuji , Itabashi Atsushi , Yumoto Motoshige
Published: March 2010

Plasma CVD is a candidate technology for the fabrication of optical polymer waveguides. It can deposit a film on any surface geometry and any substrate material at a temperature under 200 °C in a vacuum process. It also provides good thickness controllability and uniformity of the deposition film. In the present study, the effects of the deposition temperature on film properties, specifically the refractive index, deposition rate, and molecular structure, are discussed. The refractive index decreases as the deposition temperature rises. The logarithm of the deposition rate increases with the reciprocal of the temperature and the gradient of the deposition rate depends on the relative abundance of double bonds in the monomer source. The gradient does not change when CF4 is used instead of Ar as the gas mixed into the plasma, although the deposition rate increases by a factor of about five. We speculate that the deposition rate increases due to the increase in the abundance precursors produced by the presence of CF4 in the plasma and due to an increased abundance of dangling bonds on the surface of the deposition film caused by F radicals. We further speculate that the precursors incorporated into the polymer are selected on the substrate by the density of adsorption sites and the adsorption energy. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 27–35, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10171
Microwave absorber properties of magnetic and dielectric composite materials
Authors: Joon An Young , Nishida Ken , Yamamoto Takashi , Ueda Shunkichi , Deguchi Takeshi
Published: March 2010

In recent years, because of rapid progress in wireless technology, microwave absorbers or noise suppressors have become necessary for an environment with safe electromagnetic wave levels. To design microwave absorbers or noise suppressors, it is necessary to have a knowledge of the complex permittivity εr*and permeability εr*. In this report, we present the values of the complex permittivity εr*and permeability µr*for composite materials including a magnetic component (iron, Fe coated with Fe3O4) and a dielectric component (titanium oxide, TiO2) obtained by varying the Fe/TiO2volume fraction ratio. By varying this ratio, we can change the values of the complex permeability (µr*=µ′r−jµ′′r) and complex permittivity (εr*=ε′r−jε′′r). The results are applied to the design of a microwave absorber in order to tailor the reflection loss and the central frequency to particular requirements, for example, the conditions required for ETC (5.8 GHz) use in Japan. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 18–26, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10206
Compact feed circuit with quarter‐wavelength transmission line matrix controlling beams in three directions including boresight
Authors: Tsuji Masatoshi
Published: March 2010

A compact feed circuit with a λ/4 transmission line matrix circuit for use in array antennas to control beams in three directions, including boresight, is presented. The feed circuit antenna is composed of five switches and λ/4 transmission lines, and the feeding matrix circuit yields phase differences of ±90°and 0°. The feed circuit can obtain a reliable output signal, as there is only a small degree of deviation of output signal with variations in the line width. The feed circuit is simulated, fabricated, and evaluated for the ISM band, and the measured characteristics agree well with the results of the simulation. The size of the feed circuit is 45 (H) ×48 (W) ×3 (T) mm. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 10–17, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10218
Identification of time‐varying Wiener systems with unknown parameters
Authors: Kobayashi Yasuhide , Shiotani Yuzuru , Hikita Shinichi , Nomura Kazuya
Published: March 2010

Wiener systems which consist of a dynamic linear block followed by a static nonlinear element have been used in numerous applications. In many cases, the system parameters are affected by changes in the environmental conditions. This paper describes a new approach to the on‐line identification of time‐varying Wiener systems. The time‐varying linear parameters and the static nonlinear characteristics are estimated by neural networks which can represent various nonlinear characteristics. The initial states of the linear model in each estimation window are not available in the Wiener systems. Thus, the initial states and the other system parameters are estimated simultaneously by nonlinear optimization techniques. Furthermore, the optimal numbers of hidden units in the neural networks are determined by the minimum description length (MDL) criterion. As a result of simulation by this method, more accurate parameters can be obtained than without estimation of the initial states and MDL. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 1–9, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10247
Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp (Eur. J. Org. Chem. 11/2010)
Authors: Taglialatela‐Scafati Orazio , Pagani Alberto , Scala Fernando , De Petrocellis Luciano , Di Marzo Vincenzo , Grassi Gianpaolo , Appendino Giovanni
Published: March 2010

The cover picture shows the formula of cannabimovone, a cannabinoid with a rearranged terpenoid skeleton isolated from an industrial strain of hemp derived from the old Italian variety Carmagnola. The trade of this exceptionally tall plant (up to 5–6 m) from the homonymous Piedmontese town at the foot of the Monviso mountain (see the painting at the right) to Marseille in France was at the origin of the French revolutionary song and dance la Carmagnole. The picture shows the cultivation of Carmagnola hemp at the foot of the Vesuvio, exemplifying the collaboration between the Italian groups from Campania and Piedmont who report the discovery of cannabimovone on p. 2067 ff. The authors acknowledge Mrs. Maria Rosa Gaude for the painting, Assocanapa (Carmagnola) and Dr. Nicola Ghietti for the pictures and their help, and Dr. Alberto Massarotti for the cover page design.
The first example of MEEKC‐ICP‐MS coupling and its application for the analysis of anticancer platinum complexes
Authors: Bytzek Anna K. , Reithofer Michael R. , Galanski Mathea Sophia , Groessl Michael , Keppler Bernhard K. , Hartinger Christian G.
Published: March 2010

MEEKC is a powerful electrodriven separation technique with many applications in different disciplines, including medicinal chemistry; however, up to now the coupling to highly sensitive and selective MS detectors was limited due to the ion suppressive effect of the commonly used surfactant SDS. Herein, the first example of the coupling of MEEKC to ICP‐MS is presented and an MEEKC method for the separation of Pt(II) and Pt(IV) anticancer drugs and drug candidates was developed. Different compositions of microemulsions were evaluated and the data were compared with those collected with standard ultraviolet/visible (UV/vis) spectroscopy detection. The MEEKC‐ICP‐MS system was found to be more sensitive than MEEKC‐UV/vis and the analysis of UV/vis silent compounds is now achievable. The migration behavior of the Pt(II) and Pt(IV) compounds under investigation is correlated to their different chemical structures.
GADD45α induction in the greenscreen HC indicator assay does not occur independently of cytotoxicity
Authors: Olaharski Andrew J. , Albertini Silvio , Mueller Lutz , Zeller Andreas , Struwe Melanie , Gocke Elmar , Kolaja Kyle
Published: March 2010

Mammalian chromosomal integrity assays are influenced by cytotoxicity, a phenomenon which impacts data interpretation, assay specificity, and regulatory testing guidelines. Concordance of the GADD45α GreenScreen HC indicator assay to established in vitro and in vivo genetic toxicological assays has previously been described, yet a detailed description in the manner by which cytotoxicity influences its performance has not. Here we present a post‐hoc analysis of a previously tested set of 91 proprietary and nonproprietary compounds investigating the influence of cytotoxicity on GADD45α induction and how varying assay cutoff criteria impacts assay performance. Significant cytotoxicity was identified to accompany the majority (72%) of compounds classified as genotoxic by GADD45α induction. Decreasing the GADD45α genotoxic induction criteria (from a 50 to a 30% increase over solvent controls) resulted in an increased assay sensitivity (from 30 to 68%) and concordance (from 55 to 68%), though a concomitant decrease in specificity was also observed (from 97 to 68%). We conclude that GADD45α induction in the GreenScreen HC indicator assay is influenced by cytotoxicity and that assay performance can be improved if different cutoff criteria are implemented. Environ. Mol. Mutagen. 52:28–34, 2011. © 2010 Wiley‐Liss, Inc.
Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican‐American mothers and children
Authors: Huen Karen , Barcellos Lisa , Beckman Kenneth , Rose Sherri , Eskenazi Brenda , Holland Nina
Published: March 2010

Paraoxonase 1 (PON1) prevents oxidation of low‐density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs). More than 250 SNPs have been previously identified in the PON1 gene, yet studies of PON1 genetic variation focus primarily on a few promoter SNPs (−108, −162) and coding SNPs (192, 55). We sequenced the PON1 gene in 30 subjects from a Mexican‐American birth cohort and identified 94 polymorphisms with minor allele frequencies >5%, including several novel variants (six SNPs, one insertion, and two deletions). Variants of the PON1 gene and three SNPs from PON2 and PON3 were genotyped in 700 children and mothers from the same cohort. PON1 phenotype was established using two substrate‐specific assays: arylesterase (AREase) and paraoxonase (POase). Twelve PON1 and two PON2 polymorphisms were significantly associated with AREase activity, and 37 polymorphisms with POase activity; however, only nine were not in strong linkage disequilibrium (LD) with either PON1−108 or PON1192 (r2 > 0.20), SNPs with known effects on PON1 quantity and substrate‐specific activity. Single tagSNPs PON155 and PON1192 accounted for similar ranges of AREase variation compared to haplotypes comprised of multiple SNPs within their haplotype blocks. However, PON155 explained 11–16% of POase activity, while six SNPs in the same haplotype block explained threefold more variance (36–56%). Although LD structure in the PON cluster seems similar between Mexicans and Caucasians, allele frequencies for many polymorphisms differed strikingly. Functional effects of PON genetic variation related to susceptibility to OPs and oxidative stress also differed by age and should be considered in protecting vulnerable subpopulations. Environ. Mol. Mutagen. 52:105–116, 2011. © 2010 Wiley‐Liss, Inc.
Modeling the environmental fate of perfluorooctanoic acid and perfluorooctanoate: An investigation of the role of individual species partitioning
Authors: Webster Eva , Ellis David A. , Reid Liisa K.
Published: March 2010

A multimedia multi-species environmental fate model was developed for the conjugate pair perfluorooctanoic acid (PFOA):perfluorooctanoate (PFO). The model allows assessment of the relative contribution of each individual species, in equilibrium with each other, to the overall environmental movement of the pair. The Lake Ontario (Canada/USA) watershed system was selected for this investigation and is simulated in a single-region, seven-compartment model, including a water surface microlayer, and aqueous aerosol generation and redeposition. Results indicate that in the equilibrated presence of both PFOA and PFO, the environmental fate of the pair can be accomplished by consideration of the physical properties of the neutral acid, which govern the intermedia distribution of the pair, coupled with processes of media advection, such as air or water flow. The role of the anion, while the most populous species in the aqueous phase, appears merely to be as a source of the neutral acid for subsequent partitioning. Thus, when only the bulk aqueous phase anion concentrations are of interest a multimedia fate model is not required because these concentrations are largely predictable from the magnitude of emissions to and the advection of the phase. With neutral species partitioning, all local field measurement concentrations of the conjugate pair, PFO(A), are explained by the model to within approximately an order of magnitude, with the exception of lake sediment solids. Model results indicate that bulk aqueous phase PFO acts as a net source for PFOA to the atmosphere, where it may be subject to long-range transport (LRT). Initial calculations suggest an atmospheric LRT potential for PFO(A) of thousands of kilometers, rendering it comparable to hexachlorobenzene. Environ. Toxicol. Chem. 2010;29:1466–1475. © 2010 SETAC