bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemodialysis prophylaxis and renal replacement therapy in contrast associated acute kidney injury (CA-AKI): literature study
Authors: Satwikajati Sawitri , Kurnianingsih Novi
Published: February 2025

Contrast associated acute kidney injury (CA-AKI) had been the main focus along the development of percutaneous invasive procedure. Contrast associated acute kidney injury (CA-AKI) increase risk of dead among hospitalized patient. The use of iodine based contrast along percutaneous procedure potentially induce contrast associated acute kidney injury (CA-AKI). Many potential hazardous effect may effect individual with CA-AKI such as myocardial re-infarction, stent thrombosis, dead, and major adverse cardiac event (MACE). Many strategies had been developed to prevent and treat CA-AKI such as risk stratification, hydration with normal saline, avoid nephrotoxic drug, use of statin, and N-acetilcystein but when all strategies failed, hemodialysis prophylaxis and renal replacement therapy had potential benefit in CA-AKI.

Keywords: Contrast Associated Kidney Injury, Hemodialysis Prophylaxis, Renal Replacement Therapy
Periodontitis and venous thromboembolism risk: Investigating the connection through a systematic review and meta-analysis
Authors: Pratama Erlan Anugrah , Sadikaningtya Lirasati , Indarto Malik Jantra , Adi Andi Wahjono , Siswanto Bambang Budi
Published: February 2025

BACKGROUND: The relationship between periodontitis and venous thromboembolism (VTE) remains controversial. Some studies show an association, while others do not show an association between periodontitis and VTE.

OBJECTIVES: This study aims to determine the relationship between periodontitis and the risk of VTE using a meta-analysis approach.

METHODS: A meta-analysis study, registered in PROSPERO, was conducted from August to September 2024. The sources for article searches in this study were Scopus, Embase, and PubMed. Data on the proportion of VTE occurrences in the periodontitis and non-periodontitis groups were collected from each article, and pooled point estimates were calculated using the Mantel-Haenszel test.

RESULTS: We identified 40,397 VTE cases and 2,215,063 controls from six articles. Among these six articles, three showed an association between periodontitis and an increased risk of VTE. Additionally, we identified one article reporting that periodontitis was associated with a decreased risk of VTE. Furthermore, two articles revealed that periodontitis had no association with VTE occurrence. Our calculations using the Mantel-Haenszel test showed that, overall, an increased risk of VTE was found in individuals with periodontitis compared to those without (RR: 1.61; 95% CI: 1.09 â€“ 2.39; Egger's p: 0.7917; Heterogeneity p: <0.0001; p: 0.0200).

CONCLUSION: We have identified that periodontitis is an important factor in the occurrence of VTE.

Keywords: venous thromboembolism, periodontitis, risk factors, meta-analysis.
Predictive value of PaCO2 on mortality in patients with acute heart failure
Authors: Afifah Yuri , Prasetya Indra , Baskoro Shalahuddin Suryo , Anjarwani Setyasih
Published: February 2025

Background: Patients with AHF may experience fluctuations in carbon dioxide levels, resulting in either hypercapnia or hypocapnia. Recent research has highlighted the significance of the relationship between CO2 fluctuation and patient outcomes.

Objective: The aim of this study was to explore the relationship between arterial carbon dioxide pressure (PaCO2) upon admission to the ICCU in patients with AHF.

Methods: A single centre retrospective observational study was performed, the patient were enrolled from patient medical record between 2021 and 2023. Participants were divided into three groups based on PaCO2 levels. The study end point was length of hospitalization, mortality at ICCU and mortality in hospital. Statistical analysis used various tests to compare outcomes, with significance set at p<0.05, and ROC analysis evaluated mortality prediction.

Result: The study included 150 patients: 97 with hypocapnia, 33 with normal PaCO2, and 19 with hypercapnia. In-hospital mortality was 37.5%, and 1-month mortality was 33.3% in the hypercapnia group. PaCO2 >45 mmHg was linked to higher in-hospital mortality (OR 6.900, p <0.001) and 30-day mortality (OR 5.600, p <0.001), PaCO2 <35 mmHg showing a protective association in ICCU and in-hospital mortality (OR 0.202, p<0.001) and 30-day mortality (OR 0.237, p<0.001). Length of stay was not significantly affected by either hypocapnia or hypercapnia. The ROC for predicting in-hospital mortality was 0.648 and for 30-day mortality was 0.626 in the PaCO2 >45 mmHg group.

Conclusion: PaCO2 levels at ICCU admission predict mortality in AHF patients. Hypercapnia is associated with higher in-hospital and 30-day mortality, while hypocapnia appears protective.

Keywords: hypercapnia, hypocapnia, acute heart failure, mortality, length of stay
Effect of Adding Different Active Substances on Inhibition Zone Diameter and Microstructural Properties of Composite Bioplastics
Authors:   Politeknik Tonggak Equator Pontianak, Permatasari Nelsy Dian , Witoyo Jatmiko Eko ,   Institut Teknologi Sumatera, Susilo Donor Utomo M. ,   Pontianak State Polytechnic, Saraswati Ayu Rahayu ,   Institut Teknologi Sumatera, Masruri Masruri ,   Universitas Brawijaya, Yuwono Sudarminto Setyo ,   Universitas Brawijaya, Widjanarko Simon Bambang ,   Universitas Brawijaya
Published: February 2025

This study identifies the phytochemical compounds in ethanolic extracts of Syzygium myrtifolium leaves, applies it to developing composite bioplastics as a natural antibacterial agent, and compares it with composite bioplastics prepared with sodium benzoate, particularly regarding inhibition zone diameter and microstructure. The results showed that the phytochemicals were identified in the ethanolic extract of Syzygium myrtifolium leaves, like flavonoids, alkaloids, tannins, phenolics, terpenoids, and saponins. LC-MS confirming bioactive in it as auraptenol, calopiptin, quercetin-3-O-β-D-glucuronide, and quercetin-3-O-L-arabinopyranoside. Moreover, in vitro tests showed that composite bioplastics with the ethanolic extracts of Syzygium myrtifolium had inhibition zone diameter against E. coli, similar to those with sodium benzoate added. Additionally, the microstructure of the composite bioplastics with the ethanolic extracts of Syzygium myrtifolium was rougher, irregular, and more porous than those of another. It indicated that the ethanolic extract of Syzygium myrtifolium leaf could be used as a natural antibacterial agent to replace the chemical agent.
Implementation study of authentic assessment in physical education in Indonesia and Malaysia
Authors: Hariadi Hariadi , Valianto Budi , Akhmad Imran , Syed Ali Syed Kamaruzaman Bin
Published: February 2025

Authentic assessment is essential in the domains of Physical Education, Sports, and Health, encompassing cognitive, affective, and psychomotor dimensions. Despite the existence of assessment tools for fundamental movements, their widespread adoption remains limited. This study aims to assess the viability of the Instrument for Authentic Assessment in Physical Education (IPOPJ) within Indonesian and Malaysian elementary schools, offering a comparative analysis of the educational systems in both countries. The research objectives encompass understanding the implementation process of IPOPJ, identifying obstacles, and evaluating adherence to predefined standards. Employing concurrent triangulation, the study gathers quantitative data through questionnaires and qualitative data through observations and interviews. Analysis is focused on communication, resource availability, disposition, and bureaucratic structures. Findings from statistical analyses using Z-tests, coupled with concurrent triangulation, reveal the absence of significant differences in responses from physical education teachers in Indonesia and Malaysia, indicating a high likelihood of successful IPOPJ implementation in both countries. This study underscores the important role of effective communication, adequate resources, positive disposition, and streamlined bureaucratic structures in facilitating successful assessment implementation.
Improving reading comprehension learning for students with learning disabilities through know-want-learned strategy
Authors: Juhanaini J. , Rizqita Alya Jilan , Putri Lamina Amalia
Published: February 2025

Reading comprehension is a skill that needs to be mastered.  It helps individuals understand the context and message through reading. Therefore, it is important for students with learning disabilities to master reading comprehension skills. This research aims to improve reading comprehension of students with learning disabilities through Know-Want-Learned (KWL) strategy. This research involved three experts to validate the instrument and eight students with learning disabilities to comprehend texts to see their comprehension. This study used a pre-experimental design research method using one-group pre-test post-test design. The data analysis technique used in this study was nonparametric statistics Wilcoxon test to test the hypothesis.
Joint Effort, a mobile application to support cannabis use self-management and reinforce the use of protective behavioral strategies: development process and usability testing (Preprint)
Authors: Côté José , Auger Patricia , Chicoine Gabrielle , Cheng Jinghui , Cossette Sylvie , Fontaine Guillaume , Genest Christine , Lal Shalini , Lapierre Judith , Pagé Gabrielle M , Maheu-Cadotte Marc-André , Rouleau Geneviève , Vinette Billy , Jutras-Aswad Didier
Published: February 2025

BACKGROUND

Canada’s legalization of recreational cannabis use (CU) has made even more evident the need for innovative interventions promoting lower-risk CU. Young adults 18 to 25 are the age group with the highest prevalence of CU. Protective behavioral strategies (PBS) have been proven to help manage CU and reduce negative CU consequences. To date, few interventions have focused on PBS. To fill this gap, a mobile application (app) prototype using PBS as a means of influencing CU was developed with and for young adults.

OBJECTIVE

To describe the development process and usability testing of Joint Effort, a CU self-management mobile app prototype centered on promoting the use of PBS among young adult past-month cannabis users (< 1 month).

METHODS

Intervention Mapping (IM) and a co-design approach were used. Six steps were followed: 1) focus groups were conducted to identify needs and preferences regarding CU interventions; 2) matrix of change objectives was used to select target behaviors and determinants; 3) theory-based intervention methods and practical applications were selected; 4) focus groups were held to validate intervention structure and examples of tailored messages; 5) preliminary intervention content was created; and 6) intervention content was transposed to a mobile app prototype. Usability was assessed through qualitative semi-structured interviews and the User Version of the Mobile Application Rating Scale (uMARS) completed by a sample of 20 university students with a mean age of 21.8 years (median: 22), of which 70% were women and 75% were undergrads. Qualitative data were analyzed using thematic analysis.

RESULTS

Four themes were identified from the interviews: Joint Effort was visually pleasing and easy to use; content was well-adapted to the target audience and non-judgmental; customization functions were appreciated; and the app was helpful and relevant to initiate behavior change. The prototype obtained a quality mean score of 4.43/5.0 (SD: 0.53) per item on the uMARS. Mean scores were obtained on five subscales: engagement (4.14/5 ±0.53), functionality (4.60/5 ±0.47), aesthetics (4.53/5 ±0.52), information quality (4.44/5 ±0.61), and subjective items (3.36/5 ±0.53).

CONCLUSIONS

Our findings highlight the added value of IM and a co-design approach that emphasizes the importance of incorporating user feedback in the development of mobile apps. On the strength of the usability results obtained, the Joint Effort prototype has since been developed into an iOS mobile app and further larger-scale evaluations are ongoing to assess its acceptability, feasibility, and efficacy.
Use of a Medical Communication Framework to Assess Quality of Automated Replies to Primary Care Portal Patient Messages: A Content Analysis. (Preprint)
Authors: Lee Natalie S. , Richards Nathan , Grandominico Jodi , Cronin Robert M. , Hendricks Amanda K , Tripathi Ravi S. , Jonas Daniel E.
Published: February 2025

BACKGROUND

Generative artificial intelligence (GenAI) tools are increasingly available to assist clinicians in responding to patient messages; however, their suitability as a tool for medical communication in primary care has not been systematically assessed.

OBJECTIVE

To assess current strengths and limitations of GenAI for primary care messages according to a medical communication framework.

METHODS

This was a descriptive quality improvement study of 201 GenAI replies to real patient messages, submitted to primary care physicians through the electronic portal at a large midwestern academic medical center. Two PCP reviewers applied a medical communication framework to develop a codebook defining strengths and limitations across five communication domains. The reviewers then assessed the presence of communication strengths and limitations for each GenAI draft, according to the codebook. All discrepancies between reviewers were reconciled via discussion, and reconciled strengths and limitations were tallied. We report the frequency of observed strengths and limitations in communication domains.

RESULTS

Across all messages (n=201), 26.4% (53 of 201) had strengths only and no limitations, while 27.4% (55 of 201) only had limitations and no strengths. The remaining 46.3% (93 of 201) had a mix of strengths and limitations. Strengths were more common than limitations in the domains of “Rapport Building” (43.3% [87 of 201] vs. 17.4% [35 of 201]) and “Enabling Next Steps” (36.3% [73 of 201] vs. 19.4% [39 of 201]). Limitations were more common in the remaining domains of “Information Delivery” (44.3% [89 of 201] vs 21.4% [43 of 201]), “Information Gathering” (29.9% [60 of 201] vs 21.4% [43 of 201]), and “Responding to Emotion” (8.5% [17 of 201] vs 4.5% [9 of 201]).

CONCLUSIONS

GenAI drafts may often contain usable portions such as expressions of respect or outlining common next steps in response to primary care patient messages. However, those strengths may be tempered by limitations in other important communication domains requiring clinician judgment, including gathering and delivering appropriate information and responding to emotion. Careful monitoring is needed to ensure that GenAI drafts do not negatively impact patient-physician communication.
Perspectives of Healthcare Professionals on the Use of Artificial Intelligence to Support Clinical Decision-Making in the Management of Multiple Long-Term Conditions: An Interview Study (Preprint)
Authors: Cooper Jennifer , Haroon Shamil , Crowe Francesca , Nirantharakumar Krishnarajah , Jackson Thomas , Fitzsimmons Leah , Hathaway Eleanor , Flanagan Sarah , Marshall Tom , Jackson Louise , Gunathilaka Niluka , D'Elia Alexander , Morris Simon George , Greenfield Sheila
Published: February 2025

BACKGROUND

Managing multiple long-term conditions (MLTC) is a complex healthcare domain. It presents both challenges and opportunities for artificial intelligence (AI) tools. Understanding healthcare practitioners’ (HCPs) experiences of MLTC management and the factors influencing their attitudes towards using AI in complex clinical decision-making is crucial for successful implementation.

OBJECTIVE

We aimed to explore the perspectives of primary care HCPs on managing MLTC and their attitudes to using AI tools to support clinical decision-making in MLTC.

METHODS

Twenty HCPs including general practitioners, geriatricians, nurses and pharmacists, were interviewed. A patient case study was used to explore how an AI tool might alter the way participants approach clinical decision-making with a patient with MLTC. We derived concepts inductively from the interview transcripts and structured them according to the five categories of Buck’s model exploring determinants of attitudes to AI. These included the concerns and expectations that contributed to the minimum requirements for HCPs to consider using an AI decision-making tool, as well as the individual characteristics and environmental influences determining their attitudes.

RESULTS

HCPs perspectives on managing MLTC were grouped into three main themes: (1) balancing multiple competing factors including accounting for patients’ social circumstances, (2) managing polypharmacy, and (3) working beyond single condition guidelines. HCPs typically expected that AI tools would improve the safety and quality of clinical decision-making. However, they expressed concerns about the impact on the therapeutic clinician-patient relationship that is fundamental to the care of patients with MLTC. The key prerequisites for clinicians adopting AI-tools in this context included improving public and patient trust in AI, saving time and integrating with existing systems, and ensuring that the rationale behind a recommendation is apparent, to enable a final decision made by an experienced human clinician.

CONCLUSIONS

This is the first study to examine the attitudes of HCPs to using AI-decision making tools in the context of managing MLTCs. HCPs were positive about the potential for AI tools to improve the safety and quality of care but unequivocal that the human touch is irreplaceable when managing patients with complex medical and social circumstances.

INTERNATIONAL REGISTERED REPORT

RR2-10.1136/bmjopen-2023-077156
ELLYSE: Voice Assistant with Advanced Task Automation and Personalization Using Python
Authors: Kumari Ms. Rekha
Published: February 2025

The primary purpose of this study is to examine the development, functionality, and practical applications of "Ellyse:
A Voice Assistant using python," an AI- driven voice assistant created to streamline daily tasks and improve productivity
through seamless voice interactions. Given the rapid advancements in AI and natural language processing (NLP), the role of
voice assistants has grown significantly, from performing simple actions to providing intelligent, interactive experiences that
enhance user convenience.
"Ellyse" is developed to respond to a diverse set of commands, enabling the management of reminders, alarms, search
functions, and system controls, making it a versatile tool for users with different needs. This studyaims to present the technical
structure, design considerations, and practical utility of "Ellyse" in everyday scenarios. By focusing on a modular development
approach and optimizing for user interaction, the assistant seeks to address current gaps in personal AI applications and
demonstrates the potential of voice-based AIin both general and specific use cases.
Blockchain in Enhancing Supply Chain Transparency
Authors: Thakur Chandan Kumar
Published: February 2025

The global supply chain is a complex and interconnected system that plays a vital role in the efficient movement of
goods across industries. However, the lack of transparency and the possibility of fraud or inefficiency have raised concerns
regarding supply chain operations. Blockchain technology, with its decentralized, secure, and immutable nature, offers a
promising solution for enhancing supply chain transparency. This research paper explores the role of blockchain in addressing
the challenges faced by traditional supply chains, examines real-world applications, and discusses its potential impact on
improving trust, efficiency, and accountability.
Optimizing Secure Communication in Intelligent Transportation Networks with Certificate-less Authorization in VANETs
Authors: M. Shanthalakshmi  , R.S. Ponmagal
Published: February 2025

As an outcome of technology progress, among the most widely used design models in intelligent transportation networks is Vehicular Ad-hoc Networks (VANETs). Assistance for Vehicle to Vehicle (V2V) connectivity is offered via VANETs. Automobile access to actual time traffic, weather, and transportation data is made possible via VANETs, which also assure traffic safety and effectiveness. The legitimacy of an organisation providing data is a crucial factor that must be taken seriously in order to ensure secure interaction in VANETs. In regards to safety mutual identification along with safe distribution of keys in VANETs continue to pose certain disadvantages considering that numerous protocols that have been suggested. However, since they depend on the authorised authority, they are susceptible to assaults through the firewall and Reliable Control (RC), which may raise safety issues amongst customers. we provide a certificate less secure authorization system that lessens the load on automobiles' internal storage and satisfies the delay criterion by doing away with certificate. The suggested system is strong and resistant against attacks from malevolent users
O perfil Museu do Agora" no Instagram
Authors: Anderson da Silva Antonio , Pagliarini de Souza Luciana Coutinho
Published: February 2025

O presente artigo tem como tema a arte nas redes sociais, e, como objetivo, compreender a dimensão do processo de apreensão do objeto de arte nelas veiculado. Para tanto, procurou-se entender o estreitamento da relação da arte com as novas mídias e as possibilidades que esses ambientes ofertam para a veiculação, acesso e produção de arte. A fundamentação teórica envolveu Santaella e Leonardo, acerca da arte nas redes sociais; e Jenkins e Botelho, acerca da dimensão das novas relações estabelecidas pelas mídias contemporâneas. Valeu-se de uma análise semiótica peirceana da arte veiculada pelo Museu do Agora na rede social Instagram. Finalmente, refletir sobre a arte veiculada nas redes sociais atuais ajuda a compreender a natureza específica que a arquitetura das redes oferta à experiencia da arte.
Perfil farmacoepidemiológico de medicamentos utilizados no controle da dor em pacientes idosos em Campo Grande/MS
Authors: Silva Dias Marcelo , Schiaveto de Souza Albert , Gomes Guerrero Moureau Ana Tereza
Published: February 2025

Objetivos: Realizar um diagnóstico situacional referente ao perfil farmacoepidemiológico de medicamentos utilizados no manejo e controle da dor em pacientes idosos atendidos na Atenção Primária de Saúde (APS) de Campo Grande/MS. É um trabalho descritivo do tipo transversal, com dados secundários, realizado na APS de Campo Grande/MS. Métodos: Foram analisados 839 formulários de consultas farmacêuticas e após a aplicação dos critérios de inclusão e exclusão, foram selecionadas 112 pacientes. Resultados: Encontrou que 87,5% são do sexo feminino e 12,5% do masculino, 62,5% tem até Ensino Fundamental, 58,18% são do lar e que 14,41% dos idosos ingerem bebida alcóolica frequentemente. Na caracterização farmacoterapêutica temos que 58,04% utilizam medicamentos caseiros como terapia alternativa e 59,46% esquece de tomar a medicação. Conclusões: A análise dos dados permitiu a elaboração do perfil farmacoterapêutico dos pacientes idosos, sendo uma fonte segura de informações. Concluímos que através deste trabalho podemos auxiliar no tratamento e manejo da dor dos pacientes idosos atendidos na APS.
Assessment of Insecticide Compatibility with Beauveria bassiana for Fall Armyworm (Spodoptera frugiperda) Management in Maize
Authors: Sugeetha G. , Adwaitha M. V. , Reddy K. S. Nikhil , Mahadevu P. , Mahadevu J.
Published: February 2025

The study was conducted during March–April, 2021, in College of Agriculture, V. C. Farm, Mandya, Karnataka, India to assess their combined efficacy and potential synergistic or antagonistic effects. The compatibility between Beauveria bassiana and various insecticides was evaluated at 7, 14, and 21 days after inoculation to assess fungal growth inhibition and colony diameter for the management of maize fall armyworm (FAW). The results revealed that, at 7 days post-inoculation, significant differences were observed in fungal growth inhibition among all insecticide combinations with Beauveria bassiana. The inhibitory effects varied from 26 to 68% with Chlorantraniliprole 9.3+ λ-cyhalothrin 4.6 ZC at half recommended concentration (RC) exhibiting the least inhibition (26%) and good colony growth (33.3 mm). At 14 days post-inoculation, all treatments displayed significant differences compared to the control, with growth inhibition ranging from 15.67 to 62.7%. Chlorantraniliprole 9.3+λ-cyhalothrin 4.6 ZC at half RC exhibited the least inhibition (15.67%) and promoted larger colony growth. At 21 days post-inoculation, significant differences persisted among treatments, with Chlorantraniliprole 9.3+λ-cyhalothrin 4.6 ZC demonstrating high compatibility and harmlessness towards B. bassiana, even at lower concentrations. In contrast, Novaluron 5.25+Emamectin benzoate 0.9 SC exhibited the highest growth inhibition (59%) at full RC. Hence, the study accomplishes the combination of Chlorantraniliprole 9.3+λ-cyhalothrin 4.6 ZC, especially at lower concentrations, demonstrated high compatibility with B. bassiana, offering an effective and sustainable approach for managing FAW.
IMPLEMENTASI TEKNOLOGI QUICK RESPONSE CODE DALAM SISTEM E-TICKETING PADA EVENT ORGANIZER
Authors: Almadina Muhammad Fitrian Shousyade , Martanto Martanto , Dikananda Arif Rinaldi , Rohman Dede
Published: February 2025

Penelitian bertujuan untuk merancang dan menguji seberapa efektif sistem dengan teknologi Quick Response Code untuk mengoptimalkan manajemen acara dan mengevaluasi kepuasan pengguna. Tingkat kepuasan diukur menggunakan metode System Usability Scale (SUS) yang dibagikan kepada 60 responden. Analisis kuesioner menghitung rerata nilai final_score SUS, disertai uji validitas dan reliabilitas menggunakan Cronbach's Alpha. Pengujian Kruskal-Wallis dilakukan untuk menilai perbedaan kepuasan sebelum dan setelah sistem diimplementasi. Hasil analisis menunjukkan nilai rerata final_score SUS sebesar 72.2 (kategori GOOD), dengan tingkat kepuasan HIGH hingga ACCEPTABLE. Uji validitas menyatakan semua pertanyaan valid, dan uji reliabilitas menghasilkan nilai Cronbach Alpha sebesar 0.69, hal ini menunjukkan konsistensi yang baik. Uji Kruskal-Wallis mengungkap perbedaan signifikan (p < 0.001), menunjukkan dampak positif sistem terhadap pengalaman pengguna.
DESAIN ANTARMUKA WEBSITE PEMASARAN MENGGUNAKAN DESIGN THINKING
Authors: Nasution Najwa Fadiyah , Nasution Tri Rahmadani , Silalahi Yayi Naulia , Syuhada Rahmad
Published: February 2025

Penelitian ini bertujuan untuk merancang desain antarmuka website pemasaran pada PDAM Tirtanadi Cabang Pemasaran Air Limbah Kota Medan, dengan fokus pada peningkatan promosi layanan pengelolaan air limbah. Pentingnya topik ini didorong oleh kurangnya pemahaman masyarakat tentang layanan tersebut menyebabkan rendahnya minat dan kesadaran masyarakat terhadap layanan PDAM Tirtanadi. Desain antarmuka ini menggunakan pendekatan Design Thinking, pendekatan ini melibatkan analisis kebutuhan pengguna, perancangan antarmuka fungsional dan estetis, serta prototyping menggunakan Figma. Hasil dari penelitian ini menunjukkan bahwa desain antarmuka berkualitas baik dapat meningkatkan pengalaman pengguna serta efektivitas promosi, hal ini diharapkan dapat meningkatkan jumlah pelanggan dan memperkuat citra PDAM Tirtanadi sebagai penyedia layanan profesional. Hasil penelitian ini juga diharapkan dapat memberikan kontribusi penting bagi pengembangan website pemasaran, tidak hanya informatif tetapi juga menarik dan mudah diakses oleh pengguna. Dengan demikian, penerapan desain secara tepat dapat mengoptimalkan proses promosi pada PDAM Tirtanadi Cabang Pemasaran Air Limbah.
ROLE OF HRCT IN EVALUATION OF PATHOLOGIES OF TEMPORAL BONE AND ITS SURGICAL INTERVENTION
Authors: Ahmed Sarfraz
Published: February 2025

Background:Advanced medical imaging techniques like CT and HRCT
help diagnose pathologies in the temporal bone, providing detailed
visualization and insights into pathological conditions, particularly soft
tissue density eg. cholesteatoma, which is difficult to diagnose through
clinical examination alone. Aims and Objectives: The study aims to
identify temporal bone changes in chronic suppurative otitis media
patients using HRCT, correlate surgical intervention with HRCT
findings, and confirm diagnosis through intraoperative findings.
Methods: Total 100 patients with temporal bone pathologies. The
patients were aged 10-60 years and provided clinical data. They underwent a Siemens Somatom AS 128 Slice multislice CT scan, revealing ear ossicle erosion, dural plate erosion, mastoid sclerosis, and scutum erosion. Surgical
procedures were scheduled based on HRCT findings. The study compared HRCT and intraoperative findings to
determine their correlation, using IBM SPSS 23rd version software and Chi-square test. Results: The study analyzed
100 patients with ossicular abnormalities, with incus erosion being the most common. Other common conditions
included scutum, malleus, and stapes erosion. Sinus plate erosion was rare, while mastoid sclerosis was common but
not as prevalent. Soft tissue/fluid attenuation was prevalent during intraoperative procedures, with the epitympanum
having the highest prevalence at 98%, indicating density-related abnormalities. Conclusions: The data offers crucial
insights into ossicular and mastoid health conditions, aiding clinicians in comprehensive assessments, accurate
diagnoses, and effective treatment strategies, ultimately improving patient care and outcomes in otolaryngology.
FERROPTOSIS AND THEIR EMERGING ROLE IN DISEASE PROGRESSION AND TREATMENT
Authors: Kumar Raushan
Published: February 2025

The iron dependent pathways known as Ferroptosis that's started by
uncontrolled lipid peroxidation and is directed by atomic systems which
incorporate different atoms and organelles. Ferroptosis has ended up a
basic component in various physiological and obsessive scenarios,
driving to significant restorative advance in a wide run of diseases.
Ferroptosis may be a modified type of cell death mechanism. This
current article represent the brief role Ferroptosis and its part within the
pathogenesis of numerous maladies.
ADENOSINE IN CARDIOVASCULAR PHYSIOLOGY: MULTIFACETED ROLES IN CORONARY VASODILATION, ATHEROPROTECTION, AND PLATELET REGULATION
Authors: Waly Mostafa
Published: February 2025

This review delves into various aspects of acute coronary syndrome
(ACS), emphasizing recent advancements. Despite progress, ACS
remains a major global health concern. The classical view linking
coronary stenoses to chronic syndrome is challenged, with optimal
medical therapy often showing better outcomes. Diverse ACS
mechanisms include plaque rupture, calcified nodules, spontaneous
dissection of the coronary arteries, and coronary artery spasm. Immune
factors, particularly neutrophils and their extracellular traps, play a dual
role in both inflammation and tissue healing. The adaptive immune
response involving T and B lymphocytes adds complexity. Metabolic and lipid-related factors like adenosine
pathways, vitamin D, and lipoprotein-associated phospholipase A2 impact atherothrombotic processes. Non-coding
RNAs, including circular, long, and microRNAs contribute to ACS. Genic therapies like Olpasiran and Inclisiran
show promise in targeting specific molecular pathways to reduce cardiovascular risk factors. Overall, this review
offers a comprehensive understanding of ACS, incorporating recent molecular, immunological, and therapeutic
advances, highlighting the need for ongoing research to improve diagnostic and treatment strategies.
CONCEPT AND REQUIREMENTS OF ESTABLISHING GREEN LABORATORIES: SCOPING REVIEW
Authors: Bhattacharya Shreya
Published: February 2025

Green laboratories are innovative research environments designed to
prioritize sustainability and environmental stewardship. These facilities
aim to minimize ecological footprints by integrating energy-efficient
designs, resource conservation, waste reduction, and fostering a culture
of sustainability. This review examines the core principles of green
laboratories and outlines the requirements for their development. It
delves into advancements in infrastructure, operational strategies,
cultural transformations, and technological solutions. Furthermore,
challenges such as high initial costs, resistance to change, and regulatory complexities are explored. Highlighting
success stories and providing a forward-looking perspective, this review aspires to guide global efforts in adopting
sustainableresearch practices and catalyze a paradigm shift toward environmentallyconscious science (1-3).
UTERINE LIPOLEIOMYOMA : A RARE CASE REPORT
Authors: Singh Madhu
Published: February 2025

Uterine lipoleiomyoma and pure lipomas are both benign tumors of fatty
tissue. They are uncommon, with a reported incidence of only 0.03% to
0.25%. Pure cervical lipomas are especially rare. While MRI can
sometimes help identify the fatty nature of these tumors before surgery,
most are diagnosed after surgery by examining the tissue under a
microscope. Despite several proposed theories, the exact origin and
development of these tumors remain a mystery. Uterine lipoleiomyomas
are a specific type of uterine leiomyoma (fibroids) distinguished by the
presence of fatty tissue. They have the potential to continue growing
even after menopause. We present the case of a patient diagnosed with a uterine lipoleiomyoma through ultrasound
and CECT imaging, which was later confirmed through tissue analysis. Currently, surgical intervention remains the
primary treatment approach for managing lipoleiomyomas.
ESTUDO DOS FLUIDOS NO ENSINO FUNDAMENTAL II: Aplicação dos Três Momentos Pedagógicos com Mapas Conceituais
Authors: Prates Shirly Inglecia Silva , Soares Maria Rosangela
Published: February 2025

A Física estuda os fenômenos da natureza e é essencial no currículo escolar desde os primeiros anos do ensino fundamental. Desse modo surge a necessidade buscar por estratégias vão além do ensino mecânico, promovendo competências como raciocínio e criatividade, estimulando os estudantes a serem protagonistas de seu próprio aprendizado.  Esse estudo investiga a utilização dos Mapas Conceituais como estratégia facilitadora para o ensino da Física dos Fluidos, empregando a metodologia dos Três Momentos Pedagógicos com estudantes do 8° e 9° anos do Ensino Fundamental. O estudo foi aplicado em quinze encontros com 25 estudantes. Ele envolveu a construção de mapas conceituais que foi parte de uma Exposição Cientifica realizada no final do projeto.  Os resultados sugerem que a metodologia promoveu uma aprendizagem significativa, envolvendo os estudantes em um ambiente colaborativo e significativo.
Respiratory system evaluation of adult primary immunodeficiency patients: a tertiary care center experience
Authors: Kaya Saltuk Buğra , Çakmak Mehmet Erdem , Bostan Özge Can , Damadoğlu Ebru , Karakaya Gül , Kalyoncu Ali Fuat , Esenboğa Saliha , Ayvaz Deniz Çağdaş , Tezcan İlhan
Published: February 2025

Introduction

Primary immunodeficiencies (PIDs) are rare diseases in which chronic pulmonary diseases are common. Chronic pulmonary complications affect the long-term survival of these patients. The aim of this study was to evaluate the accompanying lung diseases and respiratory functions in adult PID patients in the Turkish population.

Materials and Methods

Patients’ files who applied to the immunology clinic between 2015 and 2020 were evaluated retrospectively. The respiratory system was evaluated by physical examination, and if necessary, computed tomography, chest radiography, and pulmonary function test (PFT) were performed. The diagnosis of PIDs was based on the European Society of Immunodeficiency’s (ESID) criteria.

Results

A total of 186 patients were included in the study. The median age of the patients was 38 years. The distribution of the diseases included in the study in order of frequency is: Common Variable Immunodeficiency (CVID) (47.8%), Severe Combined Immunodeficiency (SCID) (22.6%), Selective IgA deficiency (SIgAD) (10.8%), X-Linked Agammaglobulinemia (XLA) (10.2%), Chronic Granulomatous Disease (CGD) (8.6%). The most common findings on chest radiology were bronchiectasis (37.1%), parenchymal nodule (32.8%), ground glass opacity (31.2%), lymphadenopathy (24.7%), fibrotic changes (24.8%), reticular opacities (23.7%) and bronchial wall thickening (23.1%). PFT’s results were lower in patients with CGD. Bronchiectasis (37.1%), asthma (22%), and tuberculosis (9.7%) were the most common lung complications.

Conclusion

We think that the frequency of other lung complications, especially asthma and bronchiectasis, is higher in adult patients with PIDs, and patient management is poor as there are no guidelines for the follow-up, diagnosis, and treatment of pulmonary complications.
The Predictability of High-Frequency Returns in the Cryptocurrency Markets and the Adaptive Market Hypothesis
Authors: Karasiński Jacek
Published: February 2025

The objective of this study was to examine the level and behaviour of the weak-form efficiency of the 16 most capitalised cryptocurrencies using intraday data. The study employed martingale difference hypothesis tests utilising the rolling window method. The predictability of high frequency returns varied over time. For most of the time, the cryptocurrencies were unpredictable. Nevertheless, their weak-form efficiency appeared to decrease along with an increase in frequency. In general, most cryptocurrencies were marked by high levels of unpredictability. However, there were some significant differences between the most and least efficient ones. To exploit market inefficiencies, investors should focus on higher frequencies. Higher frequencies should also be a concern to regulators when it comes to ensuring market efficiency.
The Evolution and Significance of Notarial Law in Modern Legal Systems
Authors: Basyarudin Basyarudin
Published: February 2025

This article explores the evolution and contemporary significance of notarial law within modern legal frameworks. Tracing its origins from ancient civilisations through the Roman Empire to present-day practices, we examine how the notary profession has adapted to changing societal needs while maintaining its core principles. The study highlights the diverse roles notaries play across different legal systems, particularly contrasting their functions in civil law and common law jurisdictions. Special attention is given to the challenges and opportunities presented by the digital age, including the emergence of electronic and remote online notarisation. These technological advancements promise increased efficiency and accessibility but also raise important questions about security, fraud prevention, and the preservation of the notary’s traditional role. By analysing these developments, this article aims to provide a comprehensive overview of notarial law’s current state and its potential future trajectory. It emphasises the ongoing importance of notaries in ensuring legal authenticity and trust while acknowledging the need for adaptation in an increasingly digital world.
Vestígios do Tempo no Cárcere
Authors: Plens Claudia , Tognoli Anderson , Zarankin Andrés , Carvalho Aline , Neves Deborah , Lima Fernanda , Oksman Silvio
Published: February 2025

É estimado que entre 1969 a 1975 cerca de sete mil pessoas tenham sido detidas no maior centro de repressão brasileiro, o Destacamento de Operação e Informação do Centro de Operações de Defesa Interna, no município de São Paulo (DOI-Codi-SP), no Brasil. Nesse espaço, inúmeras pessoas foram torturadas e dezenas, assassinadas. Recentemente uma pesquisa arqueológica interdisciplinar vem sendo realizada com o propósito de compreender de modo abrangente como ocorreram os crimes de Estado contra a sociedade civil, por meio da perspectiva da arqueologia da arquitetura e arqueologia forense, com desdobramento para ações da Arqueologia Pública. Ademais, pesquisa histórica por meio de documentos escritos e coletas de depoimentos vem sendo paralelamente desenvolvida. Este artigo tem por objetivo explorar um panorama geral da primeira fase da pesquisa, apresentar e discutir os vestígios de inscrições confeccionadas possivelmente por uma vítima na contagem do tempo de sua detenção nesse espaço. Em face das descobertas angustiantes, mas profundamente significativas, este trabalho ressalta a importância de investigações arqueológicas e históricas no processo de desvelamento e compreensão das atrocidades cometidas no DOI-Codi-SP. Através da análise dos vestígios físicos e dos relatos das vítimas, a pesquisa oferece uma nova dimensão ao entendimento dos crimes de Estado, da necessidade de um efetivo processo de Justiça de Transição, ao mesmo tempo em que reafirma o papel da Arqueologia Pública como uma ferramenta vital para a construção de memória e justiça. As inscrições na parede, registrando os dias de cárcere de um detento, não são meramente marcas em uma superfície de concreto; elas simbolizam a resiliência humana face à opressão e enfatizam a necessidade urgente de preservarmos estes espaços de memória para as futuras gerações, como locais de reflexão e aprendizado sobre o passado sombrio que jamais deve ser esquecido ou repetido.
A ocupação da encosta da serra sul catarinense: encontros culturais no Holoceno tardio
Authors: DeBlasis Paulo , Kozlowski Henrique , B. Perin Edenir , B. Campos Juliano , M. Guimarães Geovan , S. E. Farias Deisi
Published: February 2025

Este artigo sintetiza a pesquisa arqueológica feita até o momento na região meridional da encosta da serra catarinense, aqui definida pela bacia do rio Tubarão e adjacências. A presença de grupos associados às tradições Umbu, Je e Guarani é descrita, discutindo-se a natureza da ocupação dessa região. Considera-se também a emergência de padrões culturais próprios durante o Holoceno tardio, que se prolongam até época bem recente.
Um estudo das tecnologias sociais na materialidade do sítio Matão 1, Felício dos Santos, Alto Araçuaí, minas gerais
Authors: Fagundes Marcelo , Perillo Filho Átila , Fonseca Thamara Ferreira , Luna Machado Daniel , Mafra Luís Fernando Rangel de Oliveira
Published: February 2025

Este artigo traz a análise do conjunto lítico do Matão 01, Alto Araçuaí, MG. Para tanto, foram analisados 780 vestígios, utilizando como método as cadeias operatórias, vista como uma ferramenta necessária para nossas inferências acerca do passado. Nosso objetivo foi discutir como o estudo desse material tem sido pensado e, nesse caso, em um sítio com ocupações inferiores a 4200 anos AP. Ou seja, foi demostrar que a intepretação ultrapassa as ideias de que essa tecnologia foi utilizada, exclusivamente, para suprir as necessidades econômicas. Isto é, os líticos foram produzidos de acordo com a conduta sociocultural da   sociedade que a fabricou, servindo como ferramenta para muitos propósitos.
Moedas, museus e educação patrimonial: Uma análise do panorama brasileiro
Authors: Aga Pereira Passos Leticia
Published: February 2025

Este artigo busca estabelecer algumas conexões entre a pesquisa de recepção e as áreas da Arqueologia e da Museologia. Para isso, focamos na cultura material da moeda, refletindo sobre a Numismática no contexto museal brasileiro, com especial atenção à exposição de moedas e a forma como esses pequenos objetos são apresentados e interpretados no ambiente museológico. Também abordamos a questão da educação patrimonial, explorando o papel do público como sujeito cultural nos processos museais e de comunicação. Esse tema tem ganhado espaço nas reflexões sobre as dinâmicas entre emissor, meio e recepção, uma vez que evidencia o processo dialógico e comunicativo dessas interações nas áreas mencionadas.
Interview with Tim Ingold (April 2023)
Authors: C. González Cristopher , Ingold Tim
Published: February 2025

An interview with social anthropologist Tim Ingold, emeritus professor of Social Anthropology at the University of Aberdeen, Scotland. The conversation covers different aspects of his work: the study of biology, his ties with Latin American anthropologists such as Eduardo Viveiros de Castro and Cristián Simonetti, his perception of the ontological turn, archaeology, ethnography, among others.
Sob a luz da estrela D’alva
Authors: Teixeira Mendes Diego , Souza Rafael Lemos de , Oliveira Tatyana Beltrão de , Yabagata Lucas Veloso , Rocha Bárbara Freire Ribeiro , Freitas Joanne Ester Ribeiro , Silva Gustavo Furlaneto
Published: February 2025

Neste trabalho apresentamos uma proposta de uso da plataforma Tainacan para a digitalização de coleções arqueológicas. Discutimos a origem e vantagens de utilizar este plugin de wordpress, bem como sua lógica e estrutura de dados. Indicamos um potencial motivador de sua baixa adesão por instituições de arqueologia e propomos uma forma simples e eficiente de lidar com um repositório cultural para a pesquisa e curadoria arqueológica. Para tanto, demonstramos como realizamos o processo de digitalização com coleções do Museu Antropológico/UFG. Ao final, traçamos reflexões sobre os repositórios digitais e as coleções arqueológicas, apontando desafios e vantagens para a pesquisa, curadoria e comunicação em instituições museológicas.
Integration of mental health services in Family Medicine practice: a systematic review
Authors: Kantharia Farook , Alhejaili Maram , Alharbi Mohammed , Alsharif Zainab , Alshammari Reem , Al-Almutairi Faridah
Published: February 2025

Mental health services must be integrated into the healthcare context to identify psychological disturbances when patients contact family medicine practitioners. The current systematic study aimed to investigate the integration of mental health services in family medical practice. A thorough search of databases, including Scopus, PsycINFO, and Web of Science, was performed to categorize relevant research published between the years 2018 and 2023. The inclusion criteria for this study were English-language studies that focused on the integration of mental health services into family practice. A total of twelve studies were included. A review suggested that mental health issues account for 45% of global diseases and start at age 14 years. A trans-diagnostic, multidisciplinary approach is needed, particularly for young people. Measurement-based care (MBC) is effective in depression treatment, but clinical obstacles hinder its adoption. Collaboration between general practitioners (GPs) and counsellors and training staff on mental health services is crucial for community-level care. The review results emphasize the need for unpublished information, interdisciplinary teams, and improved accessibility. It also emphasizes patient education, crisis intervention techniques, and telehealth services. The review emphasizes policy, result evaluation, and cultural competence for patient-centered mental health treatment.
Determine the Pollution Indices of the Soil Near the Najaf Refinery in the Middle of Iraq
Authors: Basha Noor Th. , Issa Murtadha J.
Published: February 2025

Al-Najaf refinery produces many pollutants from fuel combustion, such as fumes and gases, which lead to heavy metal pollution in the soil. This research aims to study the pollution factors in the soil surrounding the refinery. Five soil samples were collected from different sites to analyse five heavy metals (Ni, Zn, Co, Cr, and Pb) to determine the chemical pollution level. The results found that the percentage of the metal (Co) in site No.3 was the highest due to its presence near the oil flame and toward the direction of the wind. Three different indices were applied to detect pollution levels: geo accumulation index (I-geo), pollution load index (PLI) and contamination factor (CF). The I-geo for Co, Cr, and Pb showed class 1 relative values, which indicated the sites were only slight pollution, while the I-geo for Zn showed class 2 relative values, which indicated moderate ranges of pollution, and the I-geo for Ni showed class 6 relative values, which indication extremely pollution sites. While the contamination factor for Zn was classed as class 2, indicating moderate contamination, the contamination factors for Co, Cr, Pb, and Ni were all rated as class 1, which indicates low contamination values. PLI levels in all investigated sites categorised as class 1 indicate no pollution (perfection). The gases released by the predominant wind impacted the metal percentage distribution pattern.