bluuebunny/crossref_metadata_2025 huggingface dataset:
Report in Documentary Communication in Southern Region of Russia during First Half of 18th Century
Authors: Gorban O. A.
Published: November 2023

This article examines the report as a new type of document in the business writing system of the first half of the 18th century. The aim is to identify common and distinctive features of reports from various institutions in the southern region of Russia. The materials used for this study are documents from the Don Army (State Archive of the Volgograd Region) and the Astrakhan Province (National Archive of the Republic of Kalmykia). Through a comparative analysis of their content, functions, and speech organization, it is revealed that all reports were submitted from subordinate subjects to superiors, served informative purposes, and occasionally served as accompanying documents. They shared a similar form (addressee, addresser, title, main text, date, place of creation), although there were variations in the placement of requisites, document titles, and addresser formulas. Differences were also identified, such as the larger number of reports in the documentation of the Don Army and their frequent use as accompanying documents, while Astrakhan reports often contained financial reports. In Don reports, the addresser was referred to in the final formula as “about this report,” while Astrakhan reports only included their name (or signature). It can be concluded that reports were increasingly integrated into official communication, becoming firmly established in the military sphere, and their form became more standardized, reflecting the development of common rules for document management.
Concept of Friedrich Nietzsche’s Apollonian and Dionysian and Its Influence on Aesthetic Dialogue in Two Stories by Maxim Gorky
Authors: Ozhigova M. M.
Published: November 2023

This article explores the implementation of Friedrich Nietzsche’s concept of the Apollonian and Dionysian in the works of M. Gorky. The aim of the study is to analyze the influence of Nietzsche’s ideas on Gorky’s aesthetic pursuits, both in his early and later works. The primary materials for this research are Gorky’s short story “On a Poet” (1894) and his text “Story About a Novel” (1924). The novelty of this study lies in the examination of a unique “dialogue” between these two works, which were written approximately thirty years apart. The focus of this “dialogue” is Gorky’s own aesthetic search and the impact of Nietzsche’s concept of the Apollonian and Dionysian on his development as a writer. The study provides a thorough analysis of both “On a Poet” and “Story About a Novel”, evaluating the extent to which the concept of the Apollonian and Dionysian is realized in these texts. It is shown that these works engage in a sort of “aesthetic dialogue”. The results of the study reveal direct quotations from Nietzsche’s treatise “The Birth of Tragedy” in Gorky’s texts, demonstrating the influence of Nietzsche ‘s ideas on Gorky’s views on the genesis of creativity and the questions of possibility and necessity in the creative process.
Urban Development in Western Siberia during 1930s
Authors: Aksarin V. V. , Sadykova E. F.
Published: November 2023

The subject of the study is the cities of Western Siberia, with a focus on socio-economic indicators such as education, demographics, population structure, healthcare, and housing conditions. This research introduces documents from the Russian State Archive of Economy into scholarly discourse for the first time. The influence of natural and geographical conditions on the development of Siberian cities was taken into account. Historical-comparative, historical-typological, and statistical research methods were used, as well as graphical representation of the data. A comparative quantitative analysis of the socio-economic indicators of Western Siberian cities revealed an increase in population with a majority of females over males, as well as a complexity of urban infrastructure due to the growth of medical, educational, scientific, and cultural institutions. The number of newly built residential buildings also increased, although their level of improvement remained low. The overall proportion of industrial enterprises in the cities increased, although the share of large enterprises was small, with only Omsk and Novosibirsk having slightly less than 50 % of them, and an average annual workforce exceeding 20,000 people. Examining the historical experience of development in Western Siberian cities contributes to a better understanding of the region’s settlement system history.
Newspaper ‘Gazavat’ and Issue of North Caucasus in Nazi Germany’s Propaganda in 1943-1944
Authors: Tatarov A. A.
Published: November 2023

The newspaper ‘Gazavat’ is considered in the article as a source of printed propaganda by Nazi Germany among the mountain peoples of the North Caucasus in the national formations of the Wehrmacht. In Russian and foreign historiography, the materials of ‘Gazavat’ have been poorly studied and insufficiently introduced into scientific circulation. The aim of the article is to analyze the articles of ‘Gazavat’ for 1943–1944 in order to identify the content of Germany’s specialized propaganda aimed at the peoples of the North Caucasus. Based on content analysis and thematic analysis methods, the author identifies four thematic blocks: national history, political future, fighting spirit, and religion. The conducted research showed that Germany used well-thought-out political technologies to manipulate the real costs of integrating the North Caucasus into the Russian Empire and the USSR. The release of the newspaper ‘Gazavat’ for North Caucasus units of the Wehrmacht was significantly delayed. The specialized propaganda was aimed at converting traditional institutions, national hopes, and historical traumas of the mountain peoples into a call for retribution against the Soviet regime. At the same time, a combination of the potential and expert knowledge of mountain emigrants, German political and military actors was implemented.
The Use of an Ambroxol Solution to Assess Acute Dermal Irritation on Rabbit Skin
Authors: Wahyuddin Munifah , Mukhriani  , Vera Olfiana  , Ika Puspita Sari  , Rizka Humardewayanti Asdie  , Titik Nuryastuti
Published: November 2023

Ambroxol can overcome infections due to the presence of biofilms in the body by interfering with the formation of sticky biofilms and reducing biofilm production, so it has the potential to be used in topical preparations for the treatment of infections. This study aimed to measure the irritating effect on the skin of rabbits resulting from the ambroxol solution to assess the safety of the ambroxol solution. The methods refers to BPOM 2020, namely by dabbing 0.5 ml of ambroxol solution on the back skin of rabbits, then covering it with gauze and non-irritant plasters, after 4 hours of cleaning of residues is then observed at 1 , 24, 48 and 72 hours to see whether or not there was an effect of erythema and edema arising from the influence of the experiment, and at the end of the investigation, a histopathological test was carried out. The results of the research are Macroscopically the ambroxol solution did not show any erythema and edema, so the primary irritation index score was obtained for all test solutions with a score of 0. In contrast, in the microscopic irritation test, the score for erythema was 4 and for edema was 3.  . From this research, it can be concluded that the ambroxol solution non-irritating to the skin.

 

KEYWORDS: Biofilm, ambroxol solutions, acute irritation test.
Relief and mobile veterinary careers may offer a path towards improved quality of life
Authors: Kogan Lori R. , Rishniw Mark
Published: November 2023

OBJECTIVE

Explore relief and mobile veterinarians’ views and experiences related to their current job. In addition, examine reasons why these veterinarians opted to pursue careers in relief and mobile practice.

SAMPLE

Veterinary members of the Veterinary Information Network working as relief or mobile veterinarians.

METHODS

An electronic survey distributed via the Veterinary Information Network data collection portal from May 11, 2023, through May 30, 2023.

RESULTS

A total of 444 responses were collected (125 veterinarians in mobile practice and 240 relief veterinarians). Factors most commonly reported to have a strong effect on mobile or relief veterinarians’ decision to leave their previous job included administration, hospital culture, leadership, feeling their voice was heard, and workplace schedule factors. The majority of mobile and relief practitioners reported feeling satisfied with their work-life balance (mobile, 78%; relief, 91%) as well as availability for children (mobile, 84%; relief, 84%) and other family members (mobile, 85%; relief, 87%).

CLINICAL RELEVANCE

The majority of mobile and relief practitioners who participated in this survey reported feeling satisfied or very satisfied with managing their work and life, in their ability to be present and available for their children, and having opportunity to support and care for elderly family members and those with medical needs. As the field of veterinary medicine becomes increasingly feminized, schedule flexibility and work-life balance will likely increase in importance, making careers in nonpractice settings more desirable. Traditional brick-and-mortar clinics should note that dissatisfaction with administration and office/hospital culture might drive their employees to pursue other career avenues such as relief or mobile practice.
Use of liposomal bupivacaine in dogs and cats undergoing gastrointestinal surgery is not associated with a higher rate of surgical site infections or multidrug-resistant infections
Authors: Andrews Camille , Williams Rachel , Burneko Marie
Published: November 2023

OBJECTIVE

To report the rate of surgical site infections (SSIs) after clean-contaminated and dirty gastrointestinal surgery in dogs and cats that did and did not receive incisional infiltration of Nocita and report the bacteria isolated.

ANIMALS

Client-owned dogs (n = 211) and cats (78).

METHODS

Records of dogs and cats that underwent gastrointestinal surgery at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania and the University of Florida Small Animal Hospital between July 1, 2020, and April 1, 2023, were reviewed for surgical procedures, presence of preoperative septic peritonitis, use of Nocita, perioperative antibiotics administered, postoperative antibiotic use, SSI development postoperatively, and aerobic bacteria isolated.

RESULTS

7 of 124 (5.6%) dogs that received Nocita and 9 of 87 (10.2%) that did not receive Nocita developed an SSI. No dogs presenting with septic peritonitis and given Nocita (n = 5) developed an SSI. Two of 55 (3.6%) cats that received Nocita and 1 of 23 (4%) that did not receive Nocita developed an SSI. Multidrug-resistant (MDR) Escherichia coli was the most common aerobic bacteria isolated from SSIs (n = 3), and MDR bacteria were isolated commonly from both groups (4).

CLINICAL RELEVANCE

Use of Nocita for gastrointestinal surgery in dogs and cats is not associated with higher rates of SSI than published rates of SSI after gastrointestinal surgery. Use of Nocita in dogs with preoperative septic peritonitis is not associated with the development of SSI. MDR bacteria are commonly isolated via culture from both dogs that received Nocita and those that did not.
Forum shopping in regulatory sandboxes
and the perils of experimental law-making
Authors: HANDRLICA Jakub , SHARP Vladimír , NEŠPOR Jan
Published: November 2023

The gradual emergence of regulatory sandboxes in various jurisdictions has already
triggered considerable attention of legal academia. Thus, academicians have addressed
various legal frameworks, providing for regulatory sandboxes in the field of financial and
energy technologies, artificial intelligence, medical products etc. In all these fields,
regulatory sandboxes do currently serve as a tool for facilitating these new technologies,
which could hardly emerge successfully under the rules of conventional legal frameworks.
Beside identifying the advantages of regulatory sandboxes, various risks were also identified
with respect to the prospective introduction of regulatory sandboxes in various fields of
governance. This article aims to address the feature of ‘forum shopping’, that the
spontaneous emergence of regulatory sandboxes might imply. The authors argue, that while
such forum shopping will represent an inevitable implication of legal pluralism, one may
also expect various attempts for the “passportisation” of regulatory sandboxes. At the same
time, the authors aim to address a more theoretical question, to which extent are classical
tenets of legal jurisprudence applicable to the experimental legislation?
Calidad fisicoquímica del río Mulato en Mocoa Putumayo-Colombia
Authors:   Instituto Tecnológico del Putumayo, Facultad de Ingeniería, Grupo de Investigación en Recursos Naturales Amazónicos (GRAM), Putumayo, Colombia, Agudelo Lorena , Muñoz Angie ,   Instituto Tecnológico del Putumayo, Facultad de Ingeniería, Semillero de Investigación Hinchas del Medio Ambiente, Putumayo, Colombia, Enriquez Valeria ,   Instituto Tecnológico del Putumayo, Facultad de Ingeniería, Semillero de Investigación Hinchas del Medio Ambiente, Putumayo, Colombia, Silva Nilsa ,   Instituto Tecnológico del Putumayo, Facultad de Ingeniería, Grupo de Investigación en Recursos Naturales Amazónicos (GRAM), Putumayo, Colombia, Lozano Ruth ,   Instituto Tecnológico del Putumayo, Facultad de Ingeniería, Grupo de Investigación en Recursos Naturales Amazónicos (GRAM), Putumayo, Colombia
Published: November 2023

El río Mulato abastece de agua para consumo humano el centro del municipio de Mocoa, departamento del Putumayo, Colombia. Las fuentes hídricas de esta zona del país no cuentan con estudios de calidad actualizados. Por ello, en el presente artículo se informa el análisis de los parámetros fisicoquímicos: pH, turbidez, OD, DBO5 conductividad, temperatura, DQO y SST; posteriormente, se comparó el análisis estadístico con la normatividad colombiana y se estableció el ICA. Se evidenció que el río Mulato recibe las cargas contaminantes de 35 vertimientos provenientes de dos quebradas tributarias, que incidieron en las alteraciones de los parámetros de turbiedad y pH; en cuanto a la primera, en la parte media el valor fue de 6.38 NTU, el más alto de 3 NTU y en la zona baja de 3.73 NTU; el segundo referente al pH se encuentra entre 5.6 y 5.8. Con los datos obtenidos de las muestras de agua de las tres zonas, tomadas in situ y ex situ, se estableció que aunque existe cierto grado de turbidez y contaminación, la calidad del agua del río Mulato se encuentra en aceptable, con alerta verde.
Índice de riesgo por acaparamiento del agua: propuesta metodológica de justicia hídrica
Authors:   Centro de Investigación en Biodoversidad, Alimentación y Cambio Climático, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México, Azuara-García Guadalupe , Palacios Efrén ,   Centro de Investigación en Biodoversidad, Alimentación y Cambio Climático, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México, Alcántara José ,   Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México, Pérez-Avilés Ricardo ,   Centro de Investigación en Biodoversidad, Alimentación y Cambio Climático, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México, Ortiz Benjamín ,   Centro de Investigación en Biodoversidad, Alimentación y Cambio Climático, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla / El Colegio de Puebla A.C., Puebla, México
Published: November 2023

Se propone la conformación de un índice de riesgo por acaparamiento del agua (IRAA) capaz de diferenciar territorialmente a los acaparadores, tomando en consideración el uso que éstos le dan al agua, los volúmenes que acumulan, así como el estatus del recurso en cada cuenca y acuífero. El patrón de acaparamiento se establece al identificar a concesionarios y usos cuando los volúmenes otorgados concentran al menos 80 % de las aguas superficiales y/o subterráneas del municipio. El IRAA integra el grado de presión sobre el recurso hídrico para determinar el riesgo y permite vincular la gestión hídrica y la gestión de los usos de suelo, puesto que las actividades acaparadoras de agua quedan identificadas en cada municipio. El índice se aplicó en el estado de Puebla, donde de 174 municipios que cumplieron con los requerimientos metodológicos, 45.4 % resultó con riesgo muy alto, 41.4 % con riesgo alto, 10.9 % con riesgo medio y 2.3 % con riesgo bajo. Ninguno entró en la categoría de riesgo muy bajo, mostrando una tendencia marcada de riesgo hídrico por acaparamiento en el estado, que se corrobora con la presencia de acaparadores intermunicipales, también identificados en este estudio. A través del IRAA es posible determinar zonas de prioridad en la transformación de la gestión del agua que trasciende los organismos de cuenca e incorpora los territorios municipales. Propone a su vez argumentos para la justicia ambiental. Los métodos y técnicas empleadas se ubican en el ámbito de la ciencia de datos.
Feeling in Crisis: Vicissitudes of Response in Experiments with Global Justice Education
Authors: Taylor Lisa
Published: November 2023

This paper considers the nexus of affective engagement, a critical analysis of systemic discrimination, and reflexive self-implication in education committed to social change. I ask how our inherited models and theories of learning and teaching for social change can curb our vigilance vis-à-vis the ways libidinal dynamics organize our curriculum as affective wish and our pedagogy as affective defense. I focus specifically on the qualities of global justice education—the ethical and political stakes of this project, the theories of learning, pedagogical strategies and discourses of moral development it inherits—that render learning, teaching, and learning to teach (none of which are discrete) affectively and ethically fraught. The paper examines student writing samples from a mandatory pre-service course on social and global justice education, one designed to engage future teachers in considering the inequitable global distribution of precarity and recognizability (Butler) within contemporary contexts of neoliberal globalization and war. In the writing samples, students reflect on the challenges they faced making sense of representations of the ravages of militarized capitalist globalization, in particular the challenges of creating and facilitating curriculum within which their peers might encounter such difficult knowledge. I ask, firstly, what students’ narrations of teaching social justice tell us about what is difficult in studying/teaching the devastation of the contemporary militarized, imperial global capitalist order in which we are profoundly implicated as citizens in the global North. Secondly, what can student narrations of teaching social justice tell me about what is difficult in global justice teacher education, specifically the wishes, the anxieties and discursive foreclosures underpinning my own conduct of it in this course?
Inter-connecting Aboriginal and Western Paradigms in Post-secondary Science Education: An Action Research Approach
Authors: Hogue Michelle Marie
Published: November 2023

Very few Aboriginal[1] students are successful in science courses in the Western education system, particularly at the post-secondary level. Without a science background they are excluded from entering into science-related professions such as medicine, scientific research, science education, fields of engineering environmental and biological sciences to name a few. The result has been the severe under-representation of Aboriginal people and their voice in such professions. The vast array of literature that addresses the issue of Aboriginal success in post-secondary education is quantitative in nature and done “on” Aboriginal people by non-Aboriginal people. Very little qualitative data exists, that addresses this issue from the experiential voice and perspective of the Aboriginal people themselves. This paper addresses the results of focus group discussions with Aboriginal students, faculty, teachers and community members around the issue, from their perspective and voice, of what is needed for Aboriginal success in post-secondary education with a specific focus on science. [1] The research for this project was done in collaboration with members of the surrounding Blackfoot community, the Aboriginal community indigenous to Southern Alberta. The words Aboriginal, Indigenous, Native will be used interchangeably within this paper and are meant to be inclusionary of Aboriginal peoples. Blackfoot specifically refers to members of the surrounding Aboriginal community involved in this project.
Book Review: A Deleuzian Approach to Curriculum
Authors: Waterhouse Monica
Published: November 2023

Book Review: A Deleuzian Approach to Curriculum
Fishing for difference: A case study of singularity and sensibility in critical literary life writing
Authors: Robson Claire Elizabeth , Sumara Dennis
Published: November 2023

This paper draws upon a two-year study that examined how critical literary life writing helped a group of lesbian seniors negotiate identity. As we consider the notions of difference and singularity, building upon the earlier work of one of the authors, we analyze the work of one participant - an ex nun whose life’s work has made her remarkable in the eyes of the world. However, as oral historians (Portelli, 1981; Thompson, 2009) have found, epic stories of celebration and achievement can serve to limit the scope of life narratives. This can hold especially true for marginalized individuals (Boyd, 2008). We suggest that in this instance, structured practices of close writing opened up our participant’s narrative to lyric possibility, rather than the “grammars of consequence” (Zwicky, 2006).
Taking the Quantum Leap: Arts-Based Learning as a Gateway into Exploring Transition for Senior Nursing Students
Authors: Janzen Katherine Joyce , Szabo Joanna , Jakubec Sonya L.
Published: November 2023

In a senior-baccalaureate nursing program, a student’s journey of transition to becoming a Registered Nurse is fraught with institutional and relational tensions. In a fourth-year capstone theory course focused on issues and trends in nursing leadership, we explored these tensions through arts-based learning activities. Through the theoretical lens of Janzen’s (2013) Quantum Perspective of Learning, reflective narratives illuminated student experiences of the transition and into the unknown. Our goal to inspire, to nurture, and to empower students to take their own quantum leaps took them into finite career spaces and the infinite spaces in-between and beyond.
Board Games as Play-full Pedagogical Pivots for STEM Teaching and Learning
Authors: Higgins Marc , McFeetors Janelle
Published: November 2023

Drawing inspiration from Ellsworth’s (2005) work on thinking with pedagogically nonprescriptive objects and the pedagogies they permit and prohibit, we turn our attention to similar educational “texts” increasingly used in STEM (i.e., science, technology, engineering, mathematics) education—board games. We tinker with board games as they refuse and resist the ways that STEM education often privileges cognitive destinations rather than relational learning journeys that enfold the whole learning self, the content, as well as the materiality of learning. We ask, how might games simultaneous act as locations of, and as, pedagogy that inflect experiences of student learning? To answer this question, we explore the pedagogical intents expressed by game designers themselves by their design diaries, blogs and interviews while thinking with Ellsworth’s concept of pedagogical pivot . In exploring game designers’ statements, we map out some of the potentialities that this pedagogical medium might offer STEM teaching and learning.
Leveraging Multimodal Literacies: Design of a Multimodal Research Journal
Authors: McKee Lori
Published: November 2023

This presentation explores the interplay between the researcher’s understandings of multimodal literacies (Walsh, 2011) and the design of a digital, multimodal, research journal using the Google Keep application (Google, 2018). The examples come from a year-long action research study (Pine, 2009) designed to inform the pedagogies of a novice educator. The research journal design was built upon understandings of multimodal literacy that recognize that meanings can be shaped through the researcher-digital interface (Kuby & Rowsell, 2017), and it was extended from uses of Google Keep for pedagogical documentation in kindergarten classrooms (Vaillancourt, 2017). The presentation highlights the ways that the researcher created the journal using text and publicly useable images and analyzed the data through hashtag labels. Through this discussion, the researcher considers the ways meaning was shaped through the affordances and constraints of the journal. The presentation contributes to knowledge related to the ways that multimodal literacy, and digital tools designed for teaching practice, can be used within research designs.
To Know, To Love and To Heal: PhotoStory and Duo-Ethnography as Approaches to Enhancing Social Justice and Self-Actualization in High School Classrooms
Authors: Le Giang , Blaikie Fiona , Tran Vuong
Published: November 2023

This article explores using PhotoStory to promote social justice in the classroom. Interweaving Photovoice (Wang & Burris, 1997) with story-sharing results in PhotoStory, a unique teaching and learning approach that can empower voices of marginalized high school students. Through PhotoStory, we explore possibilities for self-actualization in high schools, where a primary pedagogical goal is to disrupt inequitable social orders and change oppressive behaviors and perceptions. Coming to critical consciousness for both teachers and students is vital, leading to engagement in dialogical pedagogy (Mthethwa-Sommers, 2014). As bell hooks (1994) asserts, oppression emanates in and through differences in relation to sex/gender, class and race. Similarly, Freire (1970) highlights the critical role of literacy skills to equip those who are oppressed to speak truth to power. Contextualized by habitus (Bourdieu, 1986), creators of PhotoStory documentaries come to understand their own and others’ lived experiences, enhancing individual and collective empathy, and promoting healing, offering holistic ways to connect through culturally responsive learning, and flipped and flattened pedagogies. By applying duoethnography (Sawyer & Norris, 2013), three authors, two graduate students and one professor discuss and critique this art-based pedagogical method via experiences of utilizing PhotoStory as an experiential teaching and learning tool. Although the scholars are different in relation to age, status, gender and sexual identities, they are committed to exploring an ethic of care and pedagogical self-actualization that serves our need “to know, to love, and to heal”.
O uso da simulação realística na atividade curricular de saúde do adulto do curso de enfermagem
Authors: Encarnação Flávia Thaiane Azevedo da , Galdino Simone Daria Assunção Vasconcelos , Girard Gleyce Pinto , Silva Cecilia Carvalho da , Lobato Amanda Thayane de Oliveira , Castro Rasiel Azevedo , Valente Zila Rebeca Brito , Soares Daniete da Luz Monteiro , Jeremias Talita Izabel de Sousa Stainki , Vieira Thays Gonçalves
Published: November 2023

Objetivo: Aplicar e avaliar uma estratégia de ensino baseada em simulação realística de um caso clínico na atividade curricular. Métodos: Qualitativo e quantitativo, realizado com 29 discentes do 6º semestre do curso de enfermagem de uma faculdade de Belém-PA, de março a maio de 2022. A coleta de dados se deu a partir de uma simulação realística, com caso clínico de infarto agudo do miocárdio, após o debriefing foi aplicado um questionário com perguntas abertas e fechadas. Para a análise optamos pela análise de conteúdo de Bardin e outros autores. Resultados: A participação dos discentes, e o alcance do objetivo proposto pela simulação e o bom rendimento na discussão do caso clínico, representaram o impacto positivo da metodologia no ensino aprendizagem. Conclusão: A simulação realística como metodologia ativa teve impacto positivo no processo ensino-aprendizagem no curso de Saúde do Adulto I, pois possibilitou o estreitamento entre teoria e prática, propiciando vivências que aproximam a realidade, favorecendo um ambiente de interatividade entre os participantes. Os discentes participaram como atores e plateia, utilizamos simuladores de baixa fidelidade elaborado pelos pesquisadores pois a faculdade não dispunha.
The Emerging Role of Vitamin D in Neurological Health and Disease
Authors: Noor Amna , Shah Syed Imran Ali
Published: November 2023

Vitamin D has come up as a pluripotent biochemical modulator of several systemic functions including its well-established musculoskeletal effects functioning as well as other key roles in nervous, cardiac, immune, vascular, and endocrinological systems. It undergoes metabolic activation in the skin, liver, and kidneys to exert its systemic actions primarily through Vitamin D receptor-mediated gene expression. In recent times, the involvement of Vitamin D has been documented in the regulation of neurotrophins, neural differentiation, and maturation, and the synthesis of neuromodulators including acetylcholine, dopamine, and gamma-aminobutyric acid. Clinical studies have also highlighted the involvement of Vitamin D in neurological disorders, thereby underscoring its potential in the clinical management of such disorders. Further, research is required to determine the multipronged roles of Vitamin D and its molecular pathways in neurophysiology for the potential prevention and treatment of neurological dysfunction.
Association between multilingualism and cognitive performance among older adults in rural southern India
Authors: Menon Anjana Jayakumar , Malo Palash Kumar , Jain Shubham , Gandhi Sandhya , Sundarakumar Jonas S. , Rai Pooja , Issac Thomas Gregor
Published: November 2023

Objectives:

Recent studies have shown that multilingualism may play an important role in enhancing cognitive health. The process of language acquisition constitutes a form of natural brain training, which in turn is hypothesized to increase neuroplasticity and hence, maintains the cognitive reserve. The study aimed to analyze the relationship between the number of languages known to an individual and its effect on cognitive functioning in both healthy and cognitively impaired study participants.

Materials and Methods:

This study utilized cross-sectional (baseline) data from Srinivasapura Aging, Neuro Senescence and COGnition study, which is an ongoing community-based, longitudinal aging cohort study conducted in a rural setting in southern India. A total of 3725 participants were considered for the study. The participants were separated into two groups, namely, monolinguals (participants knowing one language) and multilingual (participants knowing more than one language). The cognitive performance of the participants was assessed using the Clinical Dementia Rating (CDR) Scale. In addition, bivariate analyses and binary logistic regression analyses were carried out.

Results:

The result of CDR scores with respect to language category shows that, among the monolingual participants, 86.5% were healthy individuals and 13.5% were with mild cognitive impairment (MCI). Similarly, among the multilingual, 94.3% were healthy and 5.7% were with MCI. The odds ratio value derived from logistic regression (0.69 95% CI (0.5-0.9)) that an individual has a higher chance of developing cognitive impairment if he/she is a monolingual.

Conclusion:

This study highlights that knowing more than one language might have a profound positive impact on cognitive health, thereby reducing the likelihood of developing cognitive decline.
Criteria for resistance in diabetic macular edema
Authors:   Ufa Eye Research Institute, Ufa, Russian Federation, Bikbov M.M. , Gilmashin T.R. ,   Ufa Eye Research Institute, Ufa, Russian Federation, Kudoyarova K.I. ,   Ufa Eye Research Institute, Ufa, Russian Federation
Published: November 2023

Purpose. To evaluate the morphofunctional features of diabetic macular edema (DME) and propose a classification of the degree of its resistance. Material and methods. The study included 448 patients (448 eyes) with newly diagnosed DME. A complete ophthalmological examination was performed, including spectral optical coherence tomography of the macular area. All patients were divided into 3 study groups depending on the anti-VEGF drug used: Brolucizumab (138), Ranibizumab (142) and Aflibercept (168). All patients (110) resistant to loading doses of an anti-VEGF drug were switched to intravitreal administration of a dexamethasone-containing implant. The observation period was 6 months. Results. According to the results of our study, the overall percentage of resistance to anti-VEGF therapy in patients with DME was 24.6%. At the same time, in group 1 it was observed in 20.2% of patients, in group 2 in 28.1% and in group 3 in 25.0%. It was found that when switching to intravitreal administration of a dexamethasone-containing biodegradable implant, there was an increase in visual acuity in the studied groups, respectively, from 0.25 to 0.67, from 0.04 to 0.3 and from 0.38 to 0.6 against the background of a decrease in retinal edema. Conclusion. The use of a dexamethasone-containing biodegradable implant after 6 months improved the architectonics of the retinal layers, increased visual acuity and reduced retinal edema in group 1 in 92.9% of patients, in group 2 in 87.5% and in group 3 in 90.5%. The developed clinical classification of the degree of DME resistance, depending on the morphofunctional features of the patient's retina, contributes to making the optimal decision regarding the choice of the most effective initial intravitreal pharmacotherapy for this disease. Key words: diabetic macular edema, anti- VEGF drugs, classification of DME resistance to intravitreal pharmacotherapy, dexamethasone implant
Ocular surface microbioma
Authors:   Russian Center for Eye and Plastic Surgery, Bashkir State Medical University, Ufa, Russian Federation, Rezbaeva G.N. , Orenburkina O.I. ,   Russian Center for Eye and Plastic Surgery, Bashkir State Medical University, Ufa, Russian Federation, Gimranova I.A. ,   Fundamental and Applied Microbiology Department, Bashkir State Medical University, Ufa, Russian Federation, Babushkin A.E. ,   Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russian Federation
Published: November 2023

The latest molecular biology methods, in particular, bacterial 16S rRNA sequencing, makes it possible to reveal the diversity of the ocular surface microbiota and expand the list of the most common types identified by cultural methods. Most metagenomic sequencing results confirm that Corynebacterium, Propionibacterium, and Staphylococcus are dominant on the healthy ocular surface. However, the obtained data point to differences in the microbial spectrum among people. Factors explaining this variability are currently unknown, in particular, to what extent it is related to people and their environment, and to what extent they are artificial, i.e. brought in from outside. Describing the microorganisms on the ocular surface is not easy due to the possible risk of bacterial contamination. More research is needed, including better experimental studies, to avoid bias in the study of the role of the ocular surface microbiome in relation to healthy and pathological conditions. In particular, the study of strain heterogeneity, overlaps, taxonomic composition and functional profile of the healthy eye surface microbiome are important for drug development, especially those based on probiotics, for the treatment of eye diseases. Key words: ocular surface of a healthy person, ocular microbiome, ocular microbiota, microbial flora, cultural method, identification by the 16S rRNA marker gene, metagenomic sequencing
The Hitchhiker’s Guide to Statistical Analysis of Feature-based Molecular Networks from Non-Targeted Metabolomics Data
Authors: Pakkir Shah Abzer K. , Walter Axel , Ottosson Filip , Russo Francesco , Navarro-Díaz Marcelo , Boldt Judith , Kalinski Jarmo-Charles , Kontou Eftychia E. , Elofson James , Polyzois Alexandros , González-Marín Carolina , Farrell Shane , Aggerbeck Marie R. , Pruksatrakul Thapanee , Chan Nathan , Wang Yunshu , Pöchhacker Magdalena , Brungs Corinna , Cámara Beatriz , Caraballo-Rodríguez Andrés M. , Cumsille Andres , de Oliveira Fernanda , Dührkop Kai , El Abiead Yasin , Geibel Christian , Graves Lana G. , Hansen Martin , Heuckeroth Steffen , Knoblauch Simon , Kostenko Anastasiia , Kuijpers Mirte CM. , Mildau Kevin , Papadopoulos Lambidis Stilianos , Portal Gomes Paulo Wender , Schramm Tilman , Steuer-Lodd Karoline , Stincone Paolo , Tayyab Sibgha , Vitale Giovanni Andrea , Wagner Berenike C. , Xing Shipei , Yazzie Marquis T. , Zuffa Simone , de Kruijff Martinus , Beemelmanns Christine , Link Hannes , Mayer Christoph , van der Hooft Justin JJ , Damiani Tito , Pluskal Tomáš , Dorrestein Pieter C. , Stanstrup Jan , Schmid Robin , Wang Mingxun , Aron Allegra T. , Ernst Madeleine , Petras Daniel
Published: November 2023

Feature-Based Molecular Networking (FBMN) is a popular analysis approach for LC-MS/MS-based non-targeted metabolomics data. While processing LC-MS/MS data through FBMN is fairly streamlined, downstream data handling and statistical interrogation is often a key bottleneck. Especially, users new to statistical analysis struggle to effectively handle and analyze complex data matrices. In this protocol, we provide a comprehensive guide for the statistical analysis of FBMN results. We explain the data structure and principles of data clean-up and normalization, as well as uni- and multivariate statistical analysis of FBMN results. We provide explanations and code in two scripting languages (R and Python) as well as the QIIME2 framework for all protocol steps, from data clean-up to statistical analysis. Additionally, the protocol is accompanied by a web application with a graphical user interface (https://fbmn-statsguide.gnps2.org/), to lower the barrier of entry for new users. Together, the protocol, code, and web app provide a complete guide and toolbox for FBMN data integration, clean-up, and advanced statistical analysis, enabling new users to uncover molecular insights from their non-targeted metabolomics data. Our protocol is tailored for the seamless analysis of FBMN results from Global Natural Products Social Molecular Networking (GNPS and GNPS2) and can be adapted to other MS feature detection, annotation, and networking tools.
Educational field practice in geomapping at the Faculty of Geology of Irkutsk University
Authors:   Irkutsk State University, Kovalenko S.N. , Dekabryov I.K. ,   Institute of the Earth's Crust SB RAS, Yuryev A.A. ,   Institute of the Earth's Crust SB RAS, Bogdanova I.A. ,   Irkutsk State University
Published: November 2023

The article provides a detailed description of all geological formations represented by: ages from the Archean Acron to the Cenozoic Era; sedimentary rocks of different stratigraphic units, different-age magmatic complexes, metamorphic and dynamometamorphic rocks and the sequence of their formation; modern loose formations of slope, proluvial-gravel, lake, alluvial, glacial, solifluctional and others minerals and organic remains, folds and discontinuities of different morphology and genesis within several key areas of the Baikal region and the vicinity of Irkutsk, which have to be studied by students at the educational field practice on geomapping, after the second year of study at the University. In the process of geomapping students are trained in methods of mapping and cameral processing of all these geological formations and presenting the results in the form of a scientific and production report at the end of the practice.
Portulan Club expedition to the Munku-Sardyk region in 2020
Authors:   Irkutsk State University, Kovalenko S.N. , Kitov A.D. ,   Institute of the Earth's Crust SB RAS, Ivanov E.N. ,   Institute of the Earth's Crust SB RAS
Published: November 2023

The results of the summer expedition 2020 of the student teaching club "Portulan" together with the staff of the Institute of Geography of the Siberian Branch of the Russian Academy of Sciences to the Munku-Sardyk mountain area, where the field research of nival-glacial formations, river and slope aufeis, slope forms of relief and processes of their formation in the valleys of the Bely Irkut, Bugovek and Muguvek rivers were carried out, are summarized: regime surveys of high altitude aufeis, as well as traditional weather monitoring and study of the rock stream "Active".
Scientific conference of students and young scientists on Earth sciences, dedicated to the 105th anniversary of ISU
Authors:   Irkutsk State University, Andreeva Yu.S. , Snopkov S.V. ,   Irkutsk State University,   Irkutsk National Research Technical University
Published: November 2023

On October 27, 2023, Irkutsk State University celebrates its next anniversary – 105 years since its foundation. Many events are timed to coincide with this event at the university, including the traditional scientific conference of students and young scientists of the Faculty of Geology.
Recent seismotectonic deformations on the Ashate volcanic plateau and their role in structure of the Dariganga volcanic field, Southeastern Mongolia
Authors:   Irkutsk State University, Chuvashova I.S. ,   Institute of the Earth's Crust SB RAS, Rasskazov S.V. ,   Irkutsk State University,   Institute of the Earth's Crust SB RAS
Published: November 2023

From instrumental measurements in southeastern Mongolia and adjacent China, weak seismicity is determined. However, 7.5-kilometer long system of ditches, probably of seismic nature, was detected in the western part of the Dariganga volcanic field, on the edge of the Ashate Plateau that resulted from erosional dissection of the 4.8–4.3 Ma shield edifice. We propose that the modern seismotectonic reactivation of the Askhate volcano is related to tectonic motions in the Late Cenozoic Tamtsag foredeep of the Nukut-Daban range, spatially associated with neotectonic reactivation of the Solonker suture.
Initial substantiation and subsequent perception of hypotheses on structure and development of the Baikal system of basins
Authors:   Irkutsk State University, Rasskazov S.V. ,   Institute of the Earth's Crust SB RAS, Chuvashova I.S. ,   Irkutsk State University,   Institute of the Earth's Crust SB RAS
Published: November 2023

The history of getting ideas on the structure and development of the Baikal system of basins and its most important structural elements is conventionally divided into stages of putting forward: 1) initial hypotheses that appeared before the 1960s, 2) numerous hypotheses associated with a large amount of work performed in connection with the development of the rifting problems in the south of Eastern Siberia in the 1960–1990s, and 3) latest hypotheses that resulted from new facts obtained through new approaches implemented in geological studies of the 2000–2020s.
Explorers and history of geological exploration in Eastern Siberia: introduction
Authors:   Irkutsk State University, Rasskazov S.V. ,   Institute of the Earth's Crust SB RAS, Kovalenko S.N. ,   Irkutsk State University, Snopkov S.V. ,   Irkutsk State University,   Siberian School of Geosciences
Published: November 2023

A special issue of the journal is dedicated to researchers and the history of geological exploration in Eastern Siberia. The articles in the issue highlight the initial contributions to the study of geology, geography and mineral resources of the territory by A.V. Lvov, S.P. Peretolchin, and V.M. Senyukov, provide information about the unknown pages of the construction of the Circum-Baikal Railway, studies of the Botogol graphite deposit, the Markov oil and gas condensate field, the Baikal system of basins, and volcanism spatially associated with its development. An overview is given of the 50-year career of geologists who graduated from ISU in 1973.
Аchievements of geologists-graduates of the Irkutsk state university in 1973 (meeting in 50 years)
Authors:   Irkutsk State University, Korolkov A.T.
Published: November 2023

Meetings of graduates of various universities occur frequently. Geologists graduates meet especially regularly every 5 years. Every meeting is the joy of returning to youth. Many graduates have long been called by name and patronymic. Although after 50 years there are... grandparents, they call each other exclusively by their first names. Such a meeting is not just communication, but also summing up. Each course brings invaluable experience in its field. A review of this work activity shows how much the geologists graduates have done useful for the country. This should be known not only by representatives of Irkutsk State University and students, but also by a wide range of readers.
Deep Learning-Powered Beamforming for 5G Massive MIMO Systems
Authors: Bendjillali Ridha Ilyas , Bendelhoum Mohammed Sofiane , Tadjeddine Ali Abderrazak , Kamline Miloud
Published: November 2023

In this study, a ResNeSt-based deep learning approach to beamforming for 5G massive multiple-input multiple-output (MIMO) systems is presented. The ResNeSt-based deep learning method is harnessed to simplify and optimize the beamforming process, consequently improving performance and efficiency of 5G and beyond communication networks. A study of beamforming capabilities has revealed potential to maximize channel capacity while minimizing interference, thus eliminating inherent limitations of the traditional methods. The proposed model shows superior adaptability to dynamic channel conditions and outperforms traditional techniques across various interference scenarios.
The Effect of ESG Performance on Stock Price Resiliency and Volatility in Korea: Evidence from COVID-19 Pandemic
Authors: Lee Dawon , Park Rae Soo
Published: November 2023

Although the COVID-19 pandemic differs in origin from traditional economic crises, its adverse effects on the global financial market are notably more pronounced. Following the initial emergence of COVID-19, stock market indices experienced a sharp decline, and stock prices became more volatile. This paper focuses on the role of Environmental, Social, and Governance (ESG) performance of Korean-listed firms during the financial crisis stemming from the COVID-19 pandemic. This paper uses the ESG score and rating data from the Korea Institute of Corporate Governance and Sustainability (KCGS). It divides the analysis period into crisis (1st quarter in 2020) and post-crisis (from 2nd quarter in 2020 to 1st quarter in 2021) periods. The results show that the stock price fall of firms with good ESG performance in the crisis period was higher than that of firms with poor performance. However, the stock price resilience of firms with good performance is markedly higher. Additionally, the price volatility of firms with good ESG performance is lower than that of firms with poor performance. This paper provides new empirical evidence that ESG activity plays an important role in stock price resiliency and volatility in Korea, even during financial crises like the one spawned by the COVID-19 pandemic.