bluuebunny/crossref_metadata_2025 huggingface dataset:
Full Scale Evaluation of GFRP Confined Softwood after Long-Term Exposure to High Humidity Environment
Authors: Almutairi Ahmed D. , Bai Yu , Zhao Xiao-Ling , Ferdous Wahid
Published: February 2023

Plantation softwood timber poles are associated with low natural durability, and it is also not clear what the effects of the high humidity environment on the long-term performance of composite action integrity of such a system. This paper presents a durability study for the proposed composite poles using (GFRP) glass fiber-reinforced polymer as a confinement system on wooden poles sourced from plantation softwood timber. Radiata pine poles of 6 m length were wrapped with multiple layers of 0°/90° woven roving biaxial E-glass fiber sheets through a wet layup process as confinement. The prepared GFRP softwood poles were then subjected to high humidity environmental conditions of up to 95 ± 2% relative humidity and 22 ± 2 °C temperature for a period of 30 months. Various lengths of confinement were considered in this study ranging from 0% to 70% of the span length. The poles had a span length of 5.4 m and were tested using a three-point bending test. Results showed that the proposed confinement system of GFRP-softwood provided a satisfactory long-term performance and the high humidity environment did not greatly affect the improvement in the mechanical performance that the GFRP system provided.
Development of Estimation Models for Individual Tree Aboveground Biomass Based on TLS-Derived Parameters
Authors: Wang Fan , Sun Yuman , Jia Weiwei , Zhu Wancai , Li Dandan , Zhang Xiaoyong , Tang Yiren , Guo Haotian
Published: February 2023

Forest biomass is a foundation for evaluating the contribution to the carbon cycle of forests, and improving biomass estimation accuracy is an urgent problem to be addressed. Terrestrial laser scanning (TLS) enables the accurate restoration of the real 3D structure of forests and provides valuable information about individual trees; therefore, using TLS to accurately estimate aboveground biomass (AGB) has become a vital technical approach. In this study, we developed individual tree AGB estimation models based on TLS-derived parameters, which are not available using traditional methods. The height parameters and crown parameters were extracted from the point cloud data of 1104 trees. Then, a stepwise regression method was used to select variables for developing the models. The results showed that the inclusion of height parameters and crown parameters in the model provided an additional 3.76% improvement in model estimation accuracy compared to a DBH-only model. The optimal linear model included the following variables: diameter at breast height (DBH), minimum contact height (Hcmin), standard deviation of height (Hstd), 1% height percentile (Hp1), crown volume above the minimum contact height (CVhcmin), and crown radius at the minimum contact height (CRhcmin). Comparing the performance of the models on the test set, the ranking is as follows: artificial neural network (ANN) model > random forest (RF) model > linear mixed-effects (LME) model > linear (LN) model. Our results suggest that TLS has substantial potential for enhancing the accuracy of individual-tree AGB estimation and can reduce the workload in the field and greatly improve the efficiency of estimation. In addition, the model developed in this paper is applicable to airborne laser scanning data and provides a novel approach for estimating forest biomass at large scales.
Microscopic Identification of 24 Timber Samples Obtained from Half-Timber Walls in Northern Spain—Considerations on the Relationship between Species and Constructive Needs
Authors: Hueto-Escobar Alicia , Vegas López-Manzanares Fernando , Mileto Camilla
Published: February 2023

Traditional architecture characteristically uses locally available materials to develop constructive systems and techniques, providing an optimum response to the needs of the population. This study focuses on half-timber walls as a traditional technique taking material form in a wide range of variants found mostly in the northwest half of Spain. Primarily aiming to ensure the broad objective of in-depth documentation, understanding, and study, the microscopic analysis of 24 timber samples obtained from different half-timber walls is proposed. This analysis aims to identify the species or species groups used and to establish a correlation with different aspects of construction including structural resistance, durability, and workability. This makes it possible to identify the predominant use of species found close to the locations from which the samples are obtained, using relatively resistant species for the structural elements of the half-timber wall, as well as the use of species with flexible and easily malleable branches for the construction of the enclosure panels. This indicates that, among the species available in a given location, builders have a degree of knowledge on the characteristics of the material, so they could choose the most suitable ones or develop specific constructive solutions based on these characteristics.
DraculR: A Web-Based Application for In Silico Haemolysis Detection in High-Throughput microRNA Sequencing Data
Authors: Smith Melanie D. , Leemaqz Shalem Y. , Jankovic-Karasoulos Tanja , McCullough Dylan , McAninch Dale , Arthurs Anya L. , Breen James , Roberts Claire T. , Pillman Katherine A.
Published: February 2023

The search for novel microRNA (miRNA) biomarkers in plasma is hampered by haemolysis, the lysis and subsequent release of red blood cell contents, including miRNAs, into surrounding fluid. The biomarker potential of miRNAs comes in part from their multicompartment origin and the long-lived nature of miRNA transcripts in plasma, giving researchers a functional window for tissues that are otherwise difficult or disadvantageous to sample. The inclusion of red-blood-cell-derived miRNA transcripts in downstream analysis introduces a source of error that is difficult to identify posthoc and may lead to spurious results. Where access to a physical specimen is not possible, our tool will provide an in silico approach to haemolysis prediction. We present DraculR, an interactive Shiny/R application that enables a user to upload miRNA expression data from a short-read sequencing of human plasma as a raw read counts table and interactively calculate a metric that indicates the degree of haemolysis contamination. The code, DraculR web tool and its tutorial are freely available as detailed herein.
Association of GSTTI, M1 and Polymorphism in GSTPI with Chronic Periodontal Disease in a Pakistani Population
Authors: Arshad Kainat , Ishfaq Uzma , Asif Muhammad , Akbar Atif , Pitafi Kehkashan Fatima , Mulghani Muhammad Rehan , Shaheen Uzman , Saeed Suleman , Arif Muhammad , Bashir Ahsan , Farooq Muhammad , Brook Alan Henry , Iqbal Furhan
Published: February 2023

Objective: Chronic periodontal disease (CP) is a multifactorial infectious and inflammatory disease that occurs due to the challenge between the immune response of the host and specific periodontal bacteria, and that can lead to tooth loss due to damage inflicted to the supporting tissue. The current study investigates the genotypes of the GSTM1 and GSTT1 genes, along with the allelic frequency of the single nucleotide polymorphism [SNP; rs1695] in the GSTP1 gene and correlates them individually or in various combinations with the incidence of CP. Methods: A total of 203 clinically confirmed CP patients and 201 control subjects were enrolled from Multan and Dera Ghazi Khan Districts in Pakistan from April to July 2022. Multiplex Polymerase Chain Reaction (PCR) and tetra-primer amplification refractory mutation system–polymerase chain reaction (T-ARMS–PCR) approaches were applied to determine the genotypes of the studied GSTs. The association of rs1695 in GSTP1 with CP was studied both individually and in various combinations with GSTM1 and T1. Results: The absence of GSTM1, the presence of GSTT1 and the presence of the mutant allele (G) at rs1695 in GSTP1 were found to be significantly associated with CP. Patients aged between 10 and 30 years were more affected by CP. Conclusion: Our results indicate that the genotypes of the analyzed GSTs affect the levels of protection from oxidative stress and may therefore influence the disease progression in CP.
Comprehensive Flood Risk Assessment: State of the Practice
Authors: Grigg Neil S.
Published: February 2023

A comprehensive assessment of flood hazards will necessitate a step-by-step analysis, starting with hydrometeorological examinations of runoff and flow, followed by an assessment of the vulnerability of those at risk. Although bodies of knowledge about these topics are large, flood risk assessments face data challenges such as climate change, population growth, and shifting land uses. Recent studies have provided comprehensive reviews of advances in the water sciences arena, and in a complementary way, this paper reviews the state of the practice of assessing flood risk, include flood scenarios, hydrometeorology, inundation modeling, flood frequency analysis, interrelationships with water infrastructure, and vulnerability of people and places. The research base for each of these topics is extensive. Some of the tools in these areas, such as hydrologic modeling, have research advances that extend back decades, whereas others, such as numerical weather prediction, have more room to evolve. It’s clear from all studies that data is crucial along the progression from atmospheric conditions to the impact on flood victims. How data are provided and shared and how they are used by stakeholders in flood risk reduction continue to evolve. Improved availability of data and uses of emerging tools of data science and machine learning are needed to assess and mitigate flood risks. Continued the development of key tools is also required, especially to improve the capability to assemble them effectively on user platforms.
The Sustainability of the Fishery Industry and Environmental Development: A Study on Factor Market Distortions
Authors: Yang Sha , Wu Jia
Published: February 2023

By reviewing the related research on the distortion of labor, capital, and technical factors, combined with the development and the upgrading status of the marine fishery industry, we used the macro data of the industry to measure the degree of price distortion of its market factors and to construct a Moore-like index and a simplified industrial structure upgrade index based on the fsQCA fuzzy set qualitative comparative analysis. The main content of this paper is related to environment and sustainable development. We found that (1) in the case of low capital factor distortion, the combination of high labor factor distortion and low marine fishery resource distortion will inhibit the rapid upgrading of the marine fishery industry structure; (2) in the case of low capital factor distortion, the combination of low labor factor distortion and high marine fishery resources will also inhibit the rapid upgrading of the marine fishery industry structure; and (3) under the combination of low labor factor distortion and low marine fishery resource factor distortion, regardless of the degree of capital factor distortion, the rapid upgrading of the marine fishery industrial structure will be inhibited; there are only differences in the timing of the impact. The impact of factor distortion on the upgrading of industrial structure lags two and three periods, respectively.
Changes in Student’s Breakfast and Snack Consumption during the Second COVID-19 Lockdown in Portugal: A Five-Wave Study
Authors: Magalhães Paula , Pereira Beatriz , Garcia Francisco , Vilas Catarina , Moreira Tânia , Rosário Pedro
Published: February 2023

The circumstances of the COVID-19 lockdown affected many students’ life spheres, including their feeding patterns and snack intake. The main goals of the present study were to: (a) analyze the changes in students’ breakfast and snacking consumption during lockdown, and (b) analyze changes in the content of the students’ snacks using the Healthy Eating Index. This study analyzed data from a sample of 726 students from 36 classes from the late elementary (i.e., fifth grade) through high school (i.e., twelfth grade) from two public schools in the north of Portugal. Data were collected in five moments during the 2020/2021 school year, pre-, during, and post-second lockdown moments. Throughout the five moments, almost 90% of the students ate breakfast, and the majority brought snacks from home to eat in school. Surprisingly, there was an increase in the quality of the snacks consumed during lockdown compared to the pre-lockdown moments (e.g., consumption of more whole and total fruits and less consumption of food with added sugar, saturated fats, refined grains, and fatty acids). Suggestions for healthy behavior promotion will be discussed, such as improving the school food environment and teaching children to prepare healthy lunch boxes.
The Effect of Ecological Management on Regional Health Inequality
Authors: Yan Fafa , Zuo Alec , Qi Wen’e , Zhou Zhimin
Published: February 2023

Ecological management has been implemented to improve individual well-being. However, it remains unclear whether this management has improved health inequality over time. Aiming to examine whether health inequality is caused by ecological management in China, we harnessed a macro-level dataset from 2001 to 2019 across 31 Chinese provinces—combined with gene and dietary culture data—and utilized a bilateral approach to pair provincial data. Empirical results of system Generalized Method of Moments (sys-GMM) estimations in benchmark and extensive models which suggest a negative and statistically significant causal effect of ecological management on health inequality. Specifically, ecological management contributes to decreasing the inequality in the population death rate, the death rate among pregnant women, the underweight newborn rate, the child malnutrition rate, and the infectious disease mortality. The results are robust to weak instruments in the sys-GMM setting and a delayed effect of ecological management. Additionally, the heterogeneity analysis shows that the causal effect of ecological management on decreasing regional health inequality is more significant and higher for subsamples in identical regions than in different regions.
Use of Outpatient Health Services by Mexicans Aged 15 Years and Older, According to Ethnicity
Authors: Pelcastre-Villafuerte Blanca Estela , Avila-Burgos Leticia , Meneses-Navarro Sergio , Cerecer-Ortiz Nadia , Montañez-Hernández Julio César
Published: February 2023

The aim of this study was to estimate the prevalence of health needs and use of outpatient services for indigenous (IP) and non-indigenous (NIP) populations aged ≥15 years, and to explore the associated factors and types of need. A cross-sectional study was conducted based on the 2018-19 National Health and Nutrition Survey. The population aged ≥15 years who had health needs and used outpatient services was identified. Logistic models were developed to explore the factors underlying the use of outpatient services. For both populations, being a woman increased the likelihood of using health services, and having health insurance was the most important variable in explaining the use of public health services. Compared to the NIP, a lower proportion of IP reported health needs during the month prior to the survey (12.8% vs. 14.7%); a higher proportion refrained from using outpatient services (19.6% vs. 12.6%); and a slightly higher proportion used public health services (56% vs. 55.4%). For the NIP, older age and belonging to a household that had received cash transfers from a social program, had few members, a high socioeconomic level, and a head with no educational lag, all increased the likelihood of using public health services. It is crucial to implement strategies that both increase the use of public health services by the IP and incorporate health-insurance coverage as a universal right.
Green Agricultural Products Supply Chain Subsidy Scheme with Green Traceability and Data-Driven Marketing of the Platform
Authors: Wang Xue , Zhang Jiayuan , Ma Deqing , Sun Hao
Published: February 2023

Government subsidies have played an important role in the development of green agriculture. In addition, the Internet platform is becoming a new channel to realize green traceability and promote the sale of agricultural products. In this context, we consider a two-level green agricultural products supply chain (GAPSC) consisting of one supplier and one Internet platform. The supplier makes green R&D investments to produce green agricultural products along with conventional agricultural products, and the platform implements green traceability and data-driven marketing. The differential game models are established under four government subsidy scenarios: no subsidy (NS), consumer subsidy (CS), supplier subsidy (SS), and supplier subsidy with green traceability cost-sharing (TSS). Then, the optimal feedback strategies under each subsidy scenario are derived using Bellman’s continuous dynamic programming theory. The comparative static analyses of key parameters are given, and the comparisons among different subsidy scenarios are conducted. Numerical examples are employed to obtain more management insights. The results show that the CS strategy is effective only if the competition intensity between two types of products is below a certain threshold. Compared to the NS scenario, the SS strategy can always improve the supplier’s green R&D level, the greenness level, market demand for green agricultural products, and the system’s utility. The TSS strategy can build on the SS strategy to further enhance the green traceability level of the platform and the greenness level and demand for green agricultural products due to the advantage of the cost-sharing mechanism. Accordingly, a win-win situation for both parties can be realized under the TSS strategy. However, the positive effect of the cost-sharing mechanism will be weakened as the supplier subsidy increases. Moreover, compared to three other scenarios, the increase in the environmental concern of the platform has a more significant negative impact on the TSS strategy.
Spatiotemporal Dynamic Evolution and Its Driving Mechanism of Carbon Emissions in Hunan Province in the Last 20 Years
Authors: Gu Huangling , Liu Yan , Xia Hao , Tan Xiao , Zeng Yanjia , Zhao Xianchao
Published: February 2023

Global warming caused by carbon emissions is an environmental issue of great concern to all sectors. Dynamic monitoring of the spatiotemporal evolution of urban carbon emissions is an important link to achieve the regional “double carbon” goal. Using 14 cities (prefectures) in Hunan Province as an example, based on the data of carbon emissions generated by land use and human production and life, and on the basis of estimating the carbon emissions in Hunan Province from 2000 to 2020 using the carbon emission coefficient method, this paper uses the Exploratory Spatial–Temporal Data Analysis (ESTDA) framework to analyze the dynamic characteristics of the spatiotemporal pattern of carbon emissions in Hunan Province from 2000 to 2020 through the Local Indicators of Spatial Association (LISA) time path, spatiotemporal transition, and the standard deviation ellipse model. The driving mechanism and spatiotemporal heterogeneity of urban carbon emissions were studied by using the geographically and temporally weighted regression model (GTWR). The results showed that: (1) In the last 20 years, the urban carbon emissions of Hunan Province have had a significant positive spatial correlation, and the spatial convergence shows a trend of first increasing and then decreasing. Therefore, priority should be given to this relevance when formulating carbon emission reduction policies in the future. (2) The center of carbon emission has been distributed between 112°15′57″~112°25′43″ E and 27°43′13″~27°49′21″ N, and the center of gravity has shifted to the southwest. The spatial distribution has changed from the “northwest–southeast” pattern to the “north–south” pattern. Cities in western and southern Hunan are the key areas of carbon emission reduction in the future. (3) Based on LISA analysis results, urban carbon emissions of Hunan from 2000 to 2020 have a strong path dependence in spatial distribution, the local spatial structure has strong stability and integration, and the carbon emissions of each city are affected by the neighborhood space. It is necessary to give full play to the synergistic emission reduction effect among regions and avoid the closure of inter-city emission reduction policies. (4) Economic development level and ecological environment have negative impacts on carbon emissions, and the population, industrial structure, technological progress, per capita energy consumption, and land use have a positive impact on carbon emissions. The regression coefficients are heterogeneous in time and space. The actual situation of each region should be fully considered to formulate differentiated emission reduction policies. The research results can provide reference for the green and low-carbon sustainable development of Hunan Province and the formulation of differentiated emission reduction policies, and provide reference for other similar cities in central China.
The Influence of Personality on Interpersonal Emotion Regulation in the Context of Psychosocial Stress
Authors: Wickett Robin , Muhlert Nils , Niven Karen
Published: February 2023

Interpersonal emotion regulation is common in everyday life and important to various outcomes. However, there is a lack of understanding about the personality profiles of people who are good at regulating others’ emotions. We conducted a dyadic study, pairing 89 ‘regulators’ and ‘targets’, with the targets subjected to a psychosocial stressor in the form of a job interview, and the regulators instructed to manage the targets’ feelings prior to the interview. We did not observe any relationship between the regulators’ personality traits and the strategies that they reported using when trying to manage the targets’ feelings, nor between the regulators’ personalities and the targets’ job interview performance. However, the anxiety levels of the targets who were paired with more extraverted regulators fluctuated less across the multiple measures throughout the study, suggesting more effective interpersonal emotion regulation. Our findings suggest that extraversion may be the most relevant trait in shaping interpersonal emotion regulation, and that the influence of personality on regulatory effectiveness is unlikely to arise due to preferences for using different types of strategies.
Impacts of the Attachment and Child Health (ATTACHTM) Parenting Program on Mothers and Their Children at Risk of Maltreatment: Phase 2 Results
Authors: Letourneau Nicole , Anis Lubna , Novick Jason , Pohl Carrie , Ntanda Henry , Hart Martha
Published: February 2023

Early adversity (e.g., family violence, parental depression, low income) places children at risk for maltreatment and negatively impacts developmental outcomes. Optimal parental reflective function (RF), defined as the parent’s ability to think about and identify thoughts, feelings, and mental states in themselves and in their children, is linked to secure attachment and may protect against suboptimal outcomes. We present the results of Phase 2 randomized control trials (RCTs) and quasi-experimental studies (QES) of the Attachment and Child Health (ATTACHTM) parental RF intervention for families with children at risk for maltreatment. Phase 2 parents experiencing adversity, along with their children aged 0–5 years (n = 45), received the 10–12-week ATTACHTM intervention. Building on completed Phase 1 pilot data, Phase 2 examined outcomes of long-standing interest, including parental RF and child development, as well as new outcomes, including parental perceived social support and executive function, and children’s behavior, sleep, and executive function. RCTs and QES revealed significant improvements in parents’ RF, perception of social support, and executive function, children’s development (i.e., communication, problem-solving, personal–social, and fine motor skills), and a decrease in children’s sleep and behavioral problems (i.e., anxiety/depression, attention problems, aggressive behavior, and externalizing problems), post-intervention. ATTACH™ positively impacts parental RF to prevent negative impacts on children at risk of maltreatment.
Long-Acting Injectable Antipsychotic Treatment during Pregnancy: A Case Series
Authors: Eleftheriou Georgios , Butera Raffaella , Sangiovanni Anna , Palumbo Claudia , Bondi Emi
Published: February 2023

Introduction: Data from the literature show that prolonged-release injectable antipsychotics (LAIs) ensure constant blood drug levels better patient compliance and offer a simpler treatment regimen for both patients and caregivers. This observational–descriptive study aims to detect the possible complications found in newborns of women with bipolar or psychotic disorders and LAI therapy during pregnancy. Methods: This study involved women with psychotic disorders during pregnancy who contacted the Teratology Information Center of Bergamo, Italy between 2016 and 2021 to receive counseling on the possible risks of exposure to LAI therapy. The follow-up procedure was carried out by telephone interview or direct contact with the patient and/or her physician. Results: In this study, LAI treatment in pregnancy was not associated with an increased risk of malformations. All but one of the children in the sample were born healthy and the mothers maintained psychopathological compensation during pregnancy. Conclusions: This study showed that, despite the small size of the sample under examination, the administration of LAIs do not compromise the normal intrauterine development of the unborn child and there were no evident major malformations.
Certainty in Uncertain Times: Dental Education during the COVID-19 Pandemic–A Qualitative Study
Authors: Goetz Katja , Wenz Hans-Jürgen , Hertrampf Katrin
Published: February 2023

Background: The restrictions concerning social contact due to the COVID-19 pandemic implied a rethinking of teaching methods at universities in general, and for practice-oriented teaching such as dental education in particular. This qualitative study aimed to assess aspects of feelings of certainty and uncertainty during this specific education process, incorporating the perspectives of teaching staff and dental students. Methods: Qualitative methods based on interviews were used for data collection. Dental students from different academic years (second, third, fourth, and fifth) and teaching staff responsible for the content and implementation of courses within the dental curriculum were recruited. The data analysis was performed by qualitative content analysis. Results: A total of 39 dental students and 19 teaching staff participated. When students and staff dealt positively with this specific situation, certainty was achieved. The availability of presentations and clear communication enhanced feelings of certainty. The participants often felt unsure about how to handle such a challenging situation and felt insecure when planning for the semester. The students missed contact with other students and argued that the information policy on their dental studies was not transparent enough. In addition, dental students and teaching staff were nervous about the risk of infection from COVID-19, especially in practical courses with patient contact. Conclusions: The COVID-19 pandemic situation leads to a rethinking of dental education. Feelings of certainty can be strengthened by clear and transparent communication as well as training in online teaching methods. To reduce uncertainty, it is crucial to establish channels for information exchange and feedback.
Factors Affecting Inpatients’ Mortality through Intentional Self-Harm at In-Hospitals in South Korea
Authors: Choi Sulki , Kim Sangmi , Lee Hyunsook
Published: February 2023

This study aimed to identify the patient characteristics, comorbidities, risk factors, and means of the self-harm of patients who attempt self-harm in and outside of a hospital, and to determine the characteristics of death by suicide among survival and death patient groups in South Korea. This study used data from the Korean National Hospital Discharge In-depth Injury Survey conducted from 2007 to 2019. In total, 7192 outpatient participants and 43 inpatient participants performed self-harm. Frequency analysis, chi-square tests, Fisher’s exact test, and logistic regression analysis were performed using STATA, version 15.0 (StataCorp), and statistical significance was set at 5%. Thirty-one inpatients who performed self-harm survived, and 12 died. Among male inpatients, the older they were, the higher the rates of self-harm and mortality rates due to falls and poisoning if they had comorbidities and financial problems. In addition, the rate of self-harm attempts within a short period after hospitalization was high. Our evidence of the characteristics of patients who performed self-harm in the hospital and the influencing factors of self-harm can be used as primary data for predicting patients at a high risk of self-harm and for creating preventative policies to reduce the risk of self-harm among inpatients in South Korea.
Time Perception in Adult ADHD: Findings from a Decade—A Review
Authors: Mette Christian
Published: February 2023

Time perception is impaired in adult ADHD. Since the term time perception subsumes different constructs, including time estimation, time reproduction, time production, and duration discrimination, it remains open whether certain domains are more affected than other domains in adult ADHD. The aim of this explorative review is to present the current state of research on time perception in adult ADHD by analysing studies from the past 10 years. A review of the literature addressing adult ADHD time perception, time estimation, and time reproduction was performed. The search strategy was conducted by using the databases “PubMed”, “Medline”, and “PSYNDEX”. The results of the present review indicate that the number of studies on time perception in adult ADHD is very scarce. Moreover, the main investigated domains of time perception in the past decade were time estimation, time reproduction and time management. Whereas some of the found studies were able to demonstrate a distinct deficit in time estimation, time reproduction and time management other studies were unable to demonstrate a clear association between ADHD and time estimation and time reproduction deficits. However, the diagnostic protocols, study design, and methodology varied between studies. Further studies on time estimation and time reproduction need to be carried out.
Consequences of COVID-19 and Its Variants: Understanding the Physical, Oral, and Psychological Impact
Authors: Afrashtehfar Kelvin I. , Jurado Carlos A. , Al-Sammarraie Amaweya , Saeed Musab H.
Published: February 2023

The highly infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic, which affects the lives of people worldwide in a variety of unprecedented ways [...]
Effects of Non-Pharmacological Sleep Interventions in Older Adults: A Systematic Review and Meta-Analysis
Authors: Gu Hye-Ja , Lee Oi-Sun
Published: February 2023

This study investigated the effects of non-pharmacological interventions on sleep in older people through a systematic review and meta-analysis. We conducted a literature search using eight electronic databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. Participant characteristics, the contents of the evaluated interventions, and the measured outcomes were systematically reviewed for 15 selected studies. We performed a meta-analysis to estimate the effect size for overall, aggregated sleep outcomes. Due to the small number of studies available for each intervention, only the overall effectiveness of non-pharmacological sleep interventions was evaluated. The evaluated interventions included exercise, aromatherapy, acupressure, cognitive behavior therapy, and meditation. Our results demonstrated that non-pharmacological interventions showed statistically significant effects on sleep (effect size = 1.00, 95% confidence interval: 0.16, 1.85, I2 = 92%, p < 0.001). After confirming publication bias and removing outliers, we found no heterogeneity (I2 = 17%, p = 0.298), with a decrease in effect size to 0.70 (95% confidence interval: 0.47, 0.93). Non-pharmacological interventions are effective for improving sleep in older adults. Future studies should continue to investigate sleep problems and interventions addressing these problems in this demographic, particularly in older women. Objective measures should be used to follow-up on the evaluated sleep interventions over the long term.
An Ultrasound–Fenton Process for the Degradation of 2,4,6-Trinitrotoluene
Authors: Li Yangang , Zhang Wenzhen , Mu Kelei , Li Shangkun , Wang Jiawei , Zhang Shujun , Wang Lu
Published: February 2023

2,4,6-Trinitrotoluene (TNT), one of the main compounds in ammunition wastewater, is harmful to the environment. In this study, the treatment efficiency of 2,4,6-TNT by different treatment processes, including ferrous ion (Fe2+), hydrogen peroxide (H2O2), Fenton, ultrasound (US) irradiation, US + Fe2+, US + H2O2 and US–Fenton process, was compared. The results showed that US–Fenton was the most effective among all methods studied. The effects of initial pH, reaction time and H2O2 to Fe2+ molar ratio were investigated. The results showed that the removal of TNT, TOC and COD was maximum at an initial pH of 3.0 and H2O2 to Fe2+ molar ratio of 10:1. TNT, TOC and COD removal was fast in the first 30 min, reaching 83%, 57% and 50%, then increased gradually to 99%, 67% and 87% until 300 min, respectively. Semi-batch mode operation increased the removal of TNT and TOC by approximately 5% and 10% at 60 min, respectively. The average carbon oxidation number (ACON) was increased from −1.7 at 30 min to a steady-state value of 0.4, indicating the mineralization of TNT. Based on GC-MS analysis, 1,3,5-trinitrobenzene, 2,4,6-trinitrobenzene acid, 3,5-dinitrobenznamine and 3,5-dinitro-p-toluidine were the major byproducts from the US–Fenton process. The TNT degradation pathway was proposed, which involved methyl group oxidation, decarboxylation, aromatic ring cleavage and hydrolysis.
Information Delayering Safety Management (IDSM): A New Method of System Safety in Urgent Situations Needs to Be Established
Authors: Lei Yu , Zhang Guirong , Liao Xiuping , Feng Wei
Published: February 2023

Organizational safety decisions rely heavily on safety information in today’s data-driven era, but there is a significant danger of information distortion that can compromise system safety. To address the issue of information distortion and enhance system safety, a new approach called information delayering safety management (IDSM) has been developed and implemented. The IDSM method combines delayering management mode and graph theory to study the relationship between information distortion management and delayering management. By using the delayering mode as a theoretical foundation for safety information management, information distortion can be reduced. The implementation of this approach from a graph theory perspective has been tested using a case study and has been proven to effectively enhance the reliability of safety information and ensure system safety. The minimum control set of the directed graph algorithm can be used to realize the whole network management of safety information distortion. The amount of safety information and signal noise can be controlled by adjusting connectivity, and safety information distortion can be regulated through the adjustment of structural holes and flow direction. Overall, IDSM offers a new, effective method for accident analysis and safety management, allowing safety professionals to make informed decisions based on robust advanced evidence.
Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects
Authors: Wang Jianping , Zhao Bin , Che Jingmin , Shang Peng
Published: February 2023

The hypoxia pathway not only regulates the organism to adapt to the special environment, such as short-term hypoxia in the plateau under normal physiological conditions, but also plays an important role in the occurrence and development of various diseases such as cancer, cardiovascular diseases, osteoporosis. Bone, as a special organ of the body, is in a relatively low oxygen environment, in which the expression of hypoxia-inducible factor (HIF)-related molecules maintains the necessary conditions for bone development. Osteoporosis disease with iron overload endangers individuals, families and society, and bone homeostasis disorder is linked to some extent with hypoxia pathway abnormality, so it is urgent to clarify the hypoxia pathway in osteoporosis to guide clinical medication efficiently. Based on this background, using the keywords “hypoxia/HIF, osteoporosis, osteoblasts, osteoclasts, osteocytes, iron/iron metabolism”, a matching search was carried out through the Pubmed and Web Of Science databases, then the papers related to this review were screened, summarized and sorted. This review summarizes the relationship and regulation between the hypoxia pathway and osteoporosis (also including osteoblasts, osteoclasts, osteocytes) by arranging the references on the latest research progress, introduces briefly the application of hyperbaric oxygen therapy in osteoporosis symptoms (mechanical stimulation induces skeletal response to hypoxic signal activation), hypoxic-related drugs used in iron accumulation/osteoporosis model study, and also puts forward the prospects of future research.
Incidence and Duration of Sick Leave Due to Work-Related Musculoskeletal Disorders in the Accommodation and Food Services Activities Sector in Slovenia: A Nationwide 5-Year Observational Study
Authors: Zerbo Šporin Dorjana , Kozinc Žiga , Prijon Ticijana , Šarabon Nejc
Published: February 2023

Objectives: The aim of this study was to analyze Slovenian data on sick leave (SL) due to the most common work-related musculoskeletal disorders (MSDs) among workers in sector I “accommodation and food services activities” from the NACE Rev2 classification. Methods: We investigated both SL incidence (i.e., number of cases) and disease severity (i.e., average SL duration) by body site, gender, age and divisions within the sector. In addition, trends in SL data (difference between 2015 and 2019) were analyzed. The effect of age group, gender and division was also assessed with relative risk (RR). RESULTS: Female gender was associated with higher risk of MSDs in young (RR = 1.91 (1.53–2.43)) and older (RR = 2.24 (1.90–2.65)) subgroups. Older age was associated with greater SL incidence and longer SL duration, regardless of gender and division within sector I. This was also reflected in relative risk calculations between older and younger groups (females: RR = 4.43; CI = 3.75–5.01; p < 0.001; males: RR = 3.71; CI = 2.89–4.77; p < 0.001). Low back disorders were the most frequent cause for SL, while lower limb disorders tended to cause the longest average SL. The SL durations were similar across divisions within the sector, while the incidence rate tended to be higher in the “accommodation” than the “food and beverage services” division. Conclusions: Special attention needs to be paid to reducing the risk of low back disorders, which are by far the most common cause of SL, and lower limb disorders, which cause the longest SL. We recommend the implementation of countermeasures that focus on early detection and rapid treatment/recovery of MSDs in older workers.
Gelatin as It Is: History and Modernity
Authors: Mikhailov Oleg V.
Published: February 2023

The data concerning the synthesis and physicochemical characteristics of one of the practically important proteins—gelatin, as well as the possibilities of its practical application, are systematized and discussed. When considering the latter, emphasis is placed on the use of gelatin in those areas of science and technology that are associated with the specifics of the spatial/molecular structure of this high-molecular compound, namely, as a binder for the silver halide photographic process, immobilized matrix systems with a nano-level organization of an immobilized substance, matrices for creating pharmaceutical/dosage forms and protein-based nanosystems. It was concluded that the use of this protein is promising in the future.
Distributed Cross-Domain Optimization for Software Defined Industrial Internet of Things
Authors: Huang Yunjing , Luo Shuyun , Xu Weiqiang
Published: February 2023

As a promising paradigm, the Industrial Internet of Things (IIoT) provides a wide range of intelligent services through the interconnection and interaction of heterogeneous networks. The quality of these services depends on how the bandwidth is shared among different flows. Hence, it is critical to design a flexible flow control strategy in multi-region management scenarios. In this paper, we establish a flow optimization model based on the IIoT networks managed by multiple Software-Defined Networking (SDN) controllers. Specifically, it jointly optimizes the real-time delivery, route selection, and constrained resource allocation to maximize the total utilities of domains. Since the topology and resources within each domain are kept secret, the problem model belongs to a multi-block problem with coupling constraints, which is difficult to be solved directly. To this end, we first decompose the problem into several intra-domain subproblems, which can be solved in parallel. By considering the inter-domain communication problem, we then introduce the slack variables to implement the interaction among domains. Finally, we design a distributed Proximal Symmetric Alternating Direction Method of Multipliers (Prox-SADMM) algorithm to solve the above joint optimization problem. Through numerical simulations, we investigate the impact of data timeliness, multi-path routing, and resource constraints on the rate utility. The performance analysis confirms that the Prox-SADMM algorithm can be well applied to large-scale networks and provides guidance to set appropriate parameter values according to the realistic requirements of IIoT networks.
Estimating the Cost of Production of Two Pentatomids and One Braconid for the Biocontrol of Spodoptera frugiperda (Lepidoptera: Noctuidae) in Maize Fields in Florida
Authors: Perier Jermaine D. , Haseeb Muhammad , Solís Daniel , Kanga Lambert H. B. , Legaspi Jesusa C.
Published: February 2023

The fall armyworm is a polyphagous lepidopteran pest that primarily feeds on valuable global crops like maize. Insecticides and transgenic crops have long been a primary option for fall armyworm control, despite growing concerns about transgenic crop resistance inheritance and the rate of insecticide resistance development. Global dissemination of the pest species has highlighted the need for more sustainable approaches to managing overwhelming populations both in their native range and newly introduced regions. As such, integrated pest management programs require more information on natural enemies of the species to make informed planning choices. In this study, we present a cost analysis of the production of three biocontrol agents of the fall armyworm over a year. This model is malleable and aimed towards small-scale growers who might benefit more from an augmentative release of natural enemies than a repetitive use of insecticides, especially since, though the benefits of using either are similar, the biological control option has a lower development cost and is more environmentally sustainable.
The Genus Spinopygina gen. nov. (Diptera, Sciaridae) from Western North America: Preliminary Molecular Phylogeny and Description of Seven New Species
Authors: Vilkamaa Pekka , Burdíková Nikola , Ševčík Jan
Published: February 2023

The genus Spinopygina gen. nov. (type species Camptochaeta uniceps Hippa & Vilkamaa, 1994) from western North America is described. The genus includes the following eight species: Spinopygina acerfalx sp. nov.; S. aurifera sp. nov.; S. camura sp. nov.; S. edura sp. nov.; S. peltata sp. nov.; S. plena sp. nov.; S. quadracantha sp. nov.; and S. uniceps (Hippa & Vilkamaa, 1994) comb. nov., transferred from Corynoptera Winnertz. The new species are described and Spinopygina uniceps is re-diagnosed. The species are keyed and illustrated. In the maximum-likelihood phylogenetic hypothesis based on four gene fragments (28S, 18S, 16S and COI), Spinopygina gen. nov. appears as the sister group of Claustropyga Hippa, Vilkamaa & Mohrig, 2003. In the same analysis, a remarkable, undescribed species is placed within Camptochaeta Hippa & Vilkamaa clade.
Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
Authors: Escobar Michael , Careta Oriol , Fernández Navas Nora , Bartkowska Aleksandra , Alberta Ludovico Andrea , Fornell Jordina , Solsona Pau , Gemming Thomas , Gebert Annett , Ibáñez Elena , Blanquer Andreu , Nogués Carme , Sort Jordi , Pellicer Eva
Published: February 2023

Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −jc, of 1.8–8.2 mA/cm2, followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts.
Towards Point of Care CRISPR-Based Diagnostics: From Method to Device
Authors: Chen Haoxiang , Zhou Xi , Wang Miao , Ren Lei
Published: February 2023

Rapid, accurate, and portable on-site detection is critical in the face of public health emergencies. Infectious disease control and public health emergency policymaking can both be aided by effective and trustworthy point of care tests (POCT). A very promising POCT method appears to be the clustered regularly interspaced short palindromic repeats and associated protein (CRISPR/Cas)-based molecular diagnosis. For on-site detection, CRISPR/Cas-based detection can be combined with multiple signal sensing methods and integrated into smart devices. In this review, sensing methods for CRISPR/Cas-based diagnostics are introduced and the advanced strategies and recent advances in CRISPR/Cas-based POCT are reviewed. Finally, the future perspectives of CRISPR and POCT are summarized and prospected.
Microangiopathy in Rheumatic Diseases
Authors: Lambova Sevdalina Nikolova
Published: February 2023

Capillaries are part of the microcirculation, which consists of arterioles, capillaries, and venules and are the connecting link between the arterial and venous blood circulation [...]