bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimisation of the delivery method for women in development of abnormalities of labour
Authors:   Chita State Medical Academy, Mudrov V.A. , Yakimova A.V. ,   Novosibirsk State Medical University, Ziganshin A.M. ,   Bashkir State Medical University
Published: July 2022

The aim of the research. To develop a means that would optimise the method of delivery for women with development of abnormalities of labour. Material and methods. Retrospective analysis of 186 cases of labour was carried out at the premises of the perinatal centre of the Regional Clinical Hospital in Chita in 2018-2021. The total sample was divided into 5 study groups: group 1 included 33 women with primary uterine inertia; group 2 included 16 women with secondary uterine inertia, group 3 included 32 women with discoordinated labour activity, group 4 included 55 women with excessive uterine activity, group 5 included 50 women with abnormal uterine contractile activity which arose against the background of the clinical narrow pelvis. All women on the eve of labour (1-2 days) underwent general and special obstetric examination. The groups were comparable in nationality, age, financial and social conditions of the women, their gestational age, frequency of genital and extragenital pathology as well as the main pathology of pregnancy. Statistical processing of the results was carried out using the IBM SPSS Statistics Version 25.0 program. Results. Optimisation of the delivery method for patients with abnormal labour was implemented on the basis of multilayer perceptron, the percentage of incorrect predictions in the learning process of which was 2.4%. The structure of the trained neural network included 14 input neurons: gestational age, labour parity, the woman’s height, uterine fundus height, presence / absence of fetal growth retardation or macrosomia, oligohydramnios, prelabour rupture of amniotic membranes and the posterior view of the foetus’s occipital presentation. Conclusion. An integrated approach based on implementation of universally available methods of objective and instrumental research on the eve of labour makes it possible to choose the correct method of delivery for patients with abnormalities of labour with an accuracy of 96.2%.
Síndrome doloroso regional complexo tipo I.
Authors: Gaspar Ana Teresa , Antunes Filipe
Published: July 2022

Type I complex regional pain syndrome is a neurophatic pain syndrome whose physiopathology is not yet fully understood. It mainly affects limb extremities and often occurs after local trauma. There is no consensus on the treatment, but early intervention seems important, particularly in the context of Physical Medicine and Rehabilitation. The authors review physiopathologic mechanisms and point to importance of an early diagnosis, since failure to recognize this clinical picture and the consequent delay in treatment may cause serious functional impairments.
Tratamento da co-infecção do virus da hepatite B e C: resposta excedida.
Authors: Barbosa João , Calinas Filipe
Published: July 2022

Hepatitis B (HBV) and hepatitis C (HCV) are the most common causes of chronic liver disease. Due to shared routes of transmission, co-infection with HBV and HCV is not uncommon. Higher rates of cirrhosis and hepatocelular carcinoma have been demonstrated in HBV/HCV co-infected patients. No treatment standard has been established for HBV/HCV co-infected patients. Treatment decisions must be made based upon identification of the dominant virus, usually HCV, thus patients should receive pegylated interferon alpha with ribavirin as for HCV monoinfection. Sustained virological response rates for HCV are broadly comparable with HCV monoinfected patients. There is limited information regarding the benefit of combination with nucleos(t)ide analogues. Treatment decisions may modify the complex interaction between HBV and HCV, as flares of the untreated virus may occur, namely with reactivation of HBV. The authors report a case of HBV/HCV co-infection, without a dominant profile, in which the treatment response exceeded expectations regarding the available evidence.
Metástase de melanoma maligno do intestino delgado: uma rara causa de hemorragia digestiva baixa.
Authors: Vaz Pedro Silva , Usurelu Sergiu , Monteiro Ana , Correia Sara , Gouveia António , Loureiro Arnandina
Published: July 2022

The malignant melanoma is the most common cause of metastatic lesion in the gastrointestinal tract, representing about 33% of all the metastatic malignant tumors of the digestive tract. In 35% of patients the small bowel is impaired, and lower gastrointestinal bleeding is a rare form of presentation. The authors report a case of a 81-year-old male with a history of malignant skin melanoma excised in 1994. Underwent middle lobectomy due right pulmonary metastasis of melanoma in 2002. In 2005, in the context of gastrointestinal bleeding is diagnosed metastases of malignant melanoma in the small bowel, and underwent a segmentary enterectomy. At present the follow-up is without symptoms.
O doente politraumatizado grave: implicações da ruralidade na mortalidade, incapacidade e qualidade de vida.
Authors: Gomes Ernestina , Moreira Daniela , Chaló Daniela , Dias Cláudia , Neutel Elisabete , Aragão Irene , Costa-Pereira Altamiro
Published: July 2022

To determine the impact of rurality in epidemiology, injury severity, health care facilities, length of stay, mortality, functional outcome and quality of life in severe trauma patients.All trauma patients admitted in our Emergency Room between 2001 and 2007. Data was collected from the prospective Trauma Registry and Follow-Up Registry 6 months after the accident. Patients were divided in three groups according to residence area: R (rural), SU (semi-urban) and U (urban). Sex, age, type of injury, length of stay in hospital and intensive care, anatomic severity (AIS), politrauma severity (ISS), physiologic severity (RTS), surveillance probability (TRISS index), pre-hospital care, previous admission in other hospital, intensive care admission, Euroqol and Extended Glasgow Outcome scale and mortality were studied in order to find a relation with rurality.1150 patients were analyzed (214 rural, 219 semi-urban, 717 urban). We found a statistical significant relation between rurality and pre-hospital care with rural patients having less medical approach in pre-hospital (R group: 12,2%; SU group: 17,7%; U group: 70,1%, p < 0,001), previous admission in other hospital with rural patients being more often admitted in another hospital before transfer to the trauma centre (R group: 89,2%; SU group: 85,8%; U group: 61,9%, p < 0,001) and intensive care admission (R group: 82,2%; SU group: 78,5%; U group: 72,4%, com p < 0,006). We did not find any significant relation between other variables studied namely severity and early or late outcome.Living in rural areas does not seam to give more burden of disease to severe trauma patients. Rural patients are similar to those that live in urban areas concerning epidemiology, injury severity and outcome. Despite lack of medical pre-hospital care and higher previous admission in other hospital in rural patients, mortality between groups didn't differ in our trauma centre.
Eccrine Porocarcinoma: Cytologic Diagnosis by Fine Needle Aspiration Biopsy (FNAB)
Authors: Kalogeraki Alexandra , Tamiolakis Dimitrios , Tsagatakis Thomas , Geronatsiou Katerina , Haniotis Vrettos , Kafoussi Maria
Published: July 2022

Introduction: Eccrine porocarcinoma is an uncommon malignant adnexal tumor of the skin. Eccrine porocarcinoma is an adenocarcinoma of the eccrine sweat gland with a propensity to recur locally and gives metastases to regional lymph nodes. This paper presents a cytologic diagnosis by fine needle aspiration of an eccrine porocarcinoma along with histopathology and immunocyto-histochemistry.Case Report: The cytologic findings of an eccrine porocarcinoma in a 76-year-old female and histologic features of the skin tumor are reported. Cytologically in fine needle aspiration biopsy, the tumor was characterized by atypical malignant cells with basophilic cytoplasm, hyperchromatic nuclei and prominent nucleoli. The cytologic diagnosis was confirmed by histology.Conclusions: The accurate preoperative diagnosis of eccrine porocarcinoma is crucial to developing a curative surgical plan. Fine needle aspiration cytology provides a convenient, safe and effective approach to solving a challenging differential diagnosis.
Osteoporosis: From Bone Biology to Individual Treatment Decision
Authors: Gonçalves Maria João , Rodrigues Ana Maria , Canhão Helena , Fonseca João Eurico
Published: July 2022

Introduction: Osteoporosis is a bone metabolic disease with increasing prevalence in ageing societies. Herein we reviewed recent epidemiologic findings and their impact in the individual patient management. In addition we dissected the major disease mechanisms which have uncovered new potential therapeutic strategies.Material and Methods: Using MeSH terms (osteoporosis, epidemiology, Portugal, Europe, pathogenesis, osteoblasts, osteoclasts, osteocytes, immune system, obesity, therapy, randomized controlled trial, efficacy, safety) as keywords. We have reviewed original studies, reviews and position papers indexed in PubMed.Results: Osteoporosis is increasingly prevalent, but recently an age-adjusted rate of fracture plateau was reached. A new fracture risk assessment tool was developed, FRAX™, which integrates the contribution of clinical risk factors associated with fragility fractures. It can be used either independently or in combination with bone mineral density. Osteoporosis treatment is offered only to a fraction of the affected individuals. In addition, 40% of the patients receiving Osteoporosis medication had a previous fracture. Relevant safety issues of different drugs used in Osteoporosis have been detected in post-marketing experience. Finally, advances in the understanding of themolecular pathways involved in Osteoporosis led to the development of new drugs.Discussion and Conclusion: Despite the existence of diagnostic tools and several effective treatments, Osteoporosis treatment is still offered only to a fraction of the affected individuals and mainly to a population with advanced disease. New and more effective treatments might change this scenario.
Resumo da Revisão Cochrane
Authors: Carneiro António Vaz , Costa João
Published: July 2022

Objectivos: Esta revisão sistemática destinou-se a determinar os efeitos sobre a mortalidade e morbilidade do rastreio do cancro da mama com mamografia em mulheres de risco baixo e em cuidados primários.Material e Métodos: Foram pesquisadas duas bases de dados - PubMed (Novembro 2012) e a World Health Organization’s International Clinical Trials Registry Platform (Novembro 2012) – para identificação de ensaios clínicos aleatorizados, prospectivos e controlados (Randomized Clinical trials – RCTs) comparando o rastreio com a não realização do rastreio. A extracção dos dados foi feita por dois investigadores que contactaram, quando necessário, os autores dos estudos para informação adicional.Resultados: Foram identificados 8 RCTs cujas amostras somaram 600 000 mulheres com idades entre 39-74 anos. Os resultados agregados dos ensaios de melhor qualidade metodológica (baixo risco de viés de selecção) não detectaram diferenças na mortalidade por cancro da mama aos 7 (risco relativo [RR] = 0,93; Intervalo de Confiança [IC] 95%: 0,79-1,09) ou aos 13 anos (RR = 0,90; IC 95%: 0,79-1,02). Os resultados agregados dos ensaios com maior risco de viés de selecção (por possível aleatorização inadequada) mostraram reduções significativas na mortalidade por cancro da mama aos 7 (RR = 0,71; IC95%: 0,61-0,83) e aos 13 anos (RR = 0,75; IC95%: 0,67-0,83). Não se verificou heterogeneidade entre os resultados dos estudos. Os resultados dos estudos de melhor epior qualidade metodológica foram semelhantes para as mulheres com menos e com mais de 50 anos de idade. Quer os resultados dos estudos de melhor qualidade, quer os resultados dos estudos com maior risco de viés, não encontraram diferenças na mortalidade oncológica (por todos os tipos de cancro) nem na mortalidade global, quer aos 7, quer aos 13 anos. Devido a deficiente classificação das causas de morte nas amostras dos RCTs, a mortalidade por cancro da mama revelou-se um resultado (outcome) enviesado a favor do rastreio. O número total de lumpectomias e mastectomias foi significativamente superior nos grupos rastreados (RR=1,31,IC95%: 1,22-1,42); no que se refere às mastectomias, os valores foram também mais altos: RR=1,20 (IC95%: 1,08-1,32). Verificou-se ainda uma utilização mais intensiva de radioterapia nos grupos rastreados (dados de 2 RCTs).Conclusões: Estes resultados indicam que não está demonstrado que o rastreio do cancro da mama com mamografia tenha umbenefício-risco favorável em mulheres de baixo risco rastreadas em cuidados primários.
Para uma reflexão intertextual a propósito da educação superior
Authors: Afonso Almerindo Janela
Published: July 2022

As reflexões que se seguem constituem o prefácio ao dossiê temático “Educação Superior: (re)configurações de um campo em movimento”. Trata-se, sobretudo, de um exercíco de intertextualidade, intencionalmente contido, em que o autor procura destacar o que de mais expressivo (ou com maior interesse pedagógico, político ou sociológico) cada um dos artigos pôde desenvolver. Sobretudo, os artigos traduzem importantes contribuições de pesquisa e a postura acadêmica engajada de pesquisadores(as) nacionais e estrangeiros com expressiva inserção nos debates sobre as (re)configurações que o complexo campo da Educação Superior vem sofrendo nas últimas décadas. São olhares plurais que contribuem significativamente para compreender contradições e tensões presentes nesse campo, os movimentos de mudança em curso e as múltiplas implicações do atual contexto pandêmico.
Do passado ao futuro glorioso
Authors: Guimarães Elisa de Magalhães e , Faria Michel Marques de
Published: July 2022

Filiado ao quadro teórico-metodológico da Análise do Discurso materialista desenvolvida por Michel Pêcheux, o presente artigo tem como objetivo apresentar uma análise das formas como o futuro e o passado são mobilizados na propaganda de regimes ditatoriais, em uma tensão entre um passado considerado glorioso e um futuro tido como promissor. Para isso, é feita uma análise de peças de propaganda da Era Vargas (1930-1945), da ditadura militar brasileira (1964-1985) e do Estado Novo português (1933-1974). O artigo discute também as condições de produção que autorizam a formulação de determinados dizeres sobre o futuro pelas ditaduras brasileiras e sobre o passado pelo regime português, ao mesmo tempo em que interditam a mobilização do futuro na propaganda portuguesa e do passado na brasileira.
Um olhar transdisciplinar de pesquisa e a constituição da subjetividade fronteiriza
Authors: Guerra Vania Maria Lescano , Almeida Willian Diego de
Published: July 2022

Ao lançar olhares oblíquos sob materialidades linguísticas que têm (re)circulado em nossa sociedade a respeito da mulher, é possível dizer o quanto suas espessuras trazem enunciados atravessados por (inter)discursos e o quanto a emergência destes tornam-se um testemunho que possibilita (trans)formar perfis identitários, bem como (des)legitimar as representações (históricas) dos sujeitos em uma determinada cultura. Partindo desse pressuposto, tem-se por objetivo problematizar, mediante recortes discursivos, possíveis efeitos de sentidos em relação à representação da mulher, de etnia indígena, e a constituição de uma subjetividade fronteriza, a partir do texto da obra “Pelas Mulheres indígenas” – idealizada pela ONG Thydêwá em parceria com a Secretaria de Políticas para as Mulheres da Presidência da República, publicada no ano de 2015.
Episteme PTM (Pertemuan Tatap Muka) SMA Kristen di Masa Covid-19
Authors: Gultom Sherly Deasy Anjuwita
Published: July 2022

Penelitian ini mengkaji tentang episteme-episteme yang muncul dari siswa, orang tua dan guru terhadap Pertemuan Tatap Muka (PTM) yang mulai dilaksanakan kembali setelah dua tahun masa Covid-19 di SMA Kristen. Penelitian ini memiliki tujuan pemetaan episteme tentang PTM yang ada di lingkungan SMA Kristen. Foucault menjabarkan episteme sebagai bentuk pengetahuan yang otoritatif atau pengetahuan yang telah dimantapkan sebagai pemaknaan terhadap situasi tertentu pada suatu zaman. Penelitian ini  menggunakan metode  kualitatif dan dianalisis melalui teori kekuasaan Foucault terkait dengan pengetahuan dan kekuasaan. Data diambil dengan melakukan indepth interview kepada tiga guru, dua siswa kelas 11, dua siswa kelas 10 dan empat siswa kelas 12 sebagai angkatan siswa yang menjalankan masa pembelajaran onsite sebelum pandemi dan masa online ketika pandemi berlangsung hingga saat ini kembali pada pembelajaran onsite.  Dua pertimbangan mengenai pelaksanaan PTM yaitu pertimbangan wilayah aman dan wilayah tidak aman serta batasan waktu menjadi acuan dalam menentukan keputusan  kapan waktu PTM dapat dilaksanakan dengan baik. Hasil penelitian menunjukkan bahwa…
 
Kata kunci: Pertemuan Tatap Muka; covid-19; SMA; Foucault; Kekuasaan
Lakossági hitek és tévhitek a makrotápanyaggokkal kapcsolatos diétákban a TikTok felhasználók körében
Authors: Szilágyi Cintia
Published: July 2022

Napjainkban egyre nagyobb szerepet kapnak azok a nem fertőző, táplálkozással összefüggő betegségek, amelyek kialakulásának kockázata nagymértékben csökkenthető lenne a megfelelő életmóddal. Amelynek egyik fontos összetevőjéről, a táplálkozásról készült az aktuális kutatás. Ma a legkedveltebb diéták Magyarországon a szénhidrát és a zsír fogyasztással összefüggő étrendek. Ezek elterjedése és a közösségi médiába való megjelenése tette lehetővé a végzett netnográfiai vizsgálatot, melynek fő célja az volt, hogy azonosítsa milyen téves következtetések vagy információk élnek a köztudatban a témával kapcsolatban. Bízom benne, hogy a kapott eredményekből levont következtetések segítséget nyújthatnak a jövőbeni kutatásokhoz és a táplálkozással kapcsolatos dilemmák feloldásához, hogy a fogyasztók a számukra legmegfelelőbb életmódot legyenek képesek kialakítani, ezzel is növelve az egészségben eltöltött évek számát.
JEL-kódok: I18, M30, M39
Scientometrics in the Library as a Research Support Tool in the Ural Branch of the Russian Academy of Sciences
Authors: Prokof’eva Yu. D.
Published: July 2022

Scientometrics today is an effective tool to analyze and evaluate the activities of scientific organizations, as well as to form strategies and forecasts for the development of scientific research. To carry out scientometric research, specialists are required with the knowledge and skills to work with scientometric data. Such specialists can be employees of research libraries. The purpose of the study is to determine the role of the research library in carrying out scientometric works in the interests of research organizations. The article describes the experience of bibliometric analysis and the development of scientometrics in the Central Scientific Library of the Ural Branch of the Russian Academy of Sciences (UB RAS). The study of the state of scientometrics in research organizations of UD RAS was carried out by the method of questionnaires. As a result, it is revealed that most often work in scientometric databases is carried out by scientific secretaries and deputy directors for scientific work. In some answers one can see a limited use of scientometric databases capabilities. Thus, the need for a specialist in scientometrics has been identified. Despite the indicated advantages of library specialists, the importance of interaction between a research organization and a library is emphasized for conducting a high-quality scientometric analysis.
Scientometric Analysis of Research on Information and Library Policy
Authors: Sokolov S. V.
Published: July 2022

The article presents tools for searching and analyzing keywords in the scientific electronic library eLIBRARY.ru. On the basis of identifying common keywords in research on information and library policy, as well as determining of the most used keywords in each of the scientific areas, the current state and prospects for the integration of library science, political science and sociological research are determined. The author comes to the following conclusions. The most important topics are related to such keywords as “information resources”, “information equality”, “information space”; library studies on the issues of state regulation of the development of the media space and the promotion of news information have not been recorded, there are very few studies on the actualization of libraries as subjects of the promotion of state civilizational values.
New Types of Libraries in the Republic of Tyva
Authors: Podik I. V.
Published: July 2022

The article focuses on the issue of the mass appearance of the “public”, “folk” and street libraries in the Republic of Tyva. The author gives the historical experience of creating such libraries in the region, concentrates herself on their future and compares it with the open of modern “public” and “folk” libraries. The aim of the study is to conceptualize this phenomenon as the process of the transformation of the “public” libraries, or as a new form of the library space organization in the region. Basing on the research results there arises a question, related to the need for creation and existence of such libraries. The conclusion is as follows. It is possible to change the library services organization in public libraries, via, e.g., the creation of reading rooms with free access to the certain parts of library collection without registration as a reader, the opening of outof-station service points in convenient places for people, the organization of bookcrossing. For further investigating the demand for the “public’, ‘folk” and street libraries it is necessary to conduct a population survey, as well as to study the quality of the library and information services of the libraries of the Republic of Tyva.
Publishing House of the Third Wave “Syntaxis” in France (1980–1992)
Authors: Bazanov P. N.
Published: July 2022

For the first time, the history of the publishing house of the third wave of Russian emigration “Syntaxis” is reconstructed, a brief outline of the history of the journal of the same name is given. The article provides a historiographic review of the study of the topic. The sources for funding the journal and the publishing house are identified. The activity of the “Syntaxis” printing house and the reasons of its origin are reconstructed. The role of the owners and founders of the publishing house M. V. Rozanova and A. D. Sinyavsky in the activities of the publishing house is shown. Particular attention is paid to the wellknown books by A. D. Sinyavsky. The publishing policy of “Syntaxis” is analysed. The thematic and typological analysis of its products is given. The publishing house has discovered the names of E. Limonov, V. Sorokin and others that are popular with modern Russian readers. Memoirs by A. Z. Steinberg attract the attention of scientists of various profiles. Non-traditional editions of “Syntaxis”are of interest to domestic and foreign bibliophiles and antiquarians. The activities of the publishing house “Maryina Roshcha” – a branch of “Syntaxis” is shown. Special attention is paid to the illustrators of the publishing house.
Mathematical Analysis: Feasibility of Using Viral Proteins to Reawaken Dormant Retrovirus Infection
Authors: Chen S.
Published: July 2022

The technique of using drugs to target latent virus reservoirs has been introduced to reawaken dormant viruses so that the immune system can attack them. However, further tests have shown this method to fail in laboratory tests. In this work, the author tries to mathematically analyze whether drugs can be used to reawaken dormant virus reservoirs and proposed the use of viral proteins to activate the sleeping virus. The results show that the amino acid sequences ARG of gag proteins of HTLV1, HTLV2, STLV1 and STLV2 match with their primer binding site GGGGGCTCG in the 3'-to-5' direction, and the amino acid sequences SPR of gag proteins of HIV1, HIV2, SIV and FIV match with their primer binding site GGCGCCCGA in the 3'-to-5' direction. The gag proteins are promising for reawakening dormant retrovirus infection. The author hence believes that the latency-reversing drugs were involved in the process of transcription of cancer genes, and the virus genome they reawaken were just happened to contain the same NF-κB binding sites, so the drugs were indirectly reawakened dormant retrovirus infection. On the other hand, it is more reliable to use viral proteins to directly reawaken retrovirus, just as androgen receptor activates the IGF1R gene.
Optimization of Lignin-Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging
Authors: AbdulRasheed-Adeleke Tawakaltu , Egwim Evans Chidi , Afolabi Ayo Samuel , Sadiku Emmanuel Rotimi , Ochigbo Stephen S
Published: July 2022

The optimization of production of lignin-nanofiber-filled thermoplastic starch composite film for potential application in food packaging was carried using Response Surface Methodology (RSM), through the adoption of the Box-Wilson Central Composite Design (CCD) with 1 center point. The effects of filler loading on moisture absorption (MAB), tensile strength [TS], percent elongation [PE] and Young’s modulus [YM]) of the films were investigated in order to construct the desirability indices of the composite. The quality of the fitting model was expressed by the coefficient of determination, R2 and the adjusted R2. Results showed that the nanocomposite films were best fitted by a quadratic regression model with a high coefficient of determination (?2) value. The selected film has desirability of 76.80%, close to the objective function, and contained 4.81% lignin and 5.00% nanofibre. The MAB, TS, YM and PE of the selected film were 17.80 %, 21.51 MPa, 25.76 MPa and 48.81%, respectively. The addition of lignin and nanofiber to starch composite reduced the moisture absorption tendency but increased the mechanical properties of the films due to the good filler/matrix interfacial adhesion. Conclusively, results suggested that these films would be suitable for packaging application.
Learning About Real Experiences From Real Users: A Blueprint for Participatory Accessibility Testing
Authors: Marcaccio Alexandra , Clarke Sara , Wetheral Alison
Published: July 2022

Although it is crucial for libraries to meet required online accessibility standards (e.g., Web Content Accessibility Guidelines 2.0), compliance with these technical standards does not guarantee optimal or equitable experiences for all library users who interact with online spaces or materials. Recent literature on accessibility testing has acknowledged the value of including people with disabilities in testing and designing digital objects and spaces. This thinking aligns with the library-based user experience (UX) principle that talking directly to users about their experiences using library services and resources is the most effective way to understand and thereby improve the overall library experience. In 2020, the UX Group at Western Libraries undertook a pilot accessibility testing initiative to plan, design, and deliver participatory accessibility testing with campus community members who had self-identified as living with a range of disabilities. Three accessibility tests were designed to assess five distinct digital objects, and 14 testing sessions were completed with eight participants. A semi-structured and participatory testing method allowed participants to freely interact with the testing objects, provide detailed feedback regarding their experiences using the objects, and recommend improvements to elements they found less accessible. This article includes an overview of considerations and challenges of the initiative as well as lessons learned in the process of securing funding, recruiting participants, designing the tests, and conducting testing. We reflect on the value of participatory accessibility testing and make recommendations for conducting similar projects at other libraries.
Psychometric Properties of the COVID-19 Burnout Scale in Brazil
Authors: Soares Ana , Vargas Adriano , Noriega José Ángel Vera Noriega
Published: July 2022

The present study aims to adapt and analyze the psychometric properties (evidence of factor validity and internal consistency) of the COVID-19 Burnout Scale in a sample of Brazilian health professionals. Two studies were carried out (N total = 427). In Study 1 [202 health professionals (age over 18), mainly women (82%) and psychologists (31.2%)], an exploratory factor analysis support the one-factor solution and the suitability of the ten items. Moreover, was also presented in Study 2 [225 health professionals (over 18 years old), the majority of women (79.6%) and psychologists (24.8%)] results of confirmatory factor analysis and item parameters (Item Response Theory) that corroborate the unifactorial structure and convergent validity with the Coronavirus Anxiety Scale. The results indicate that this measure may be suitable for use in research and in the burnout evaluation scenario.
Análisis de predictores de síntomas ansiosos, depresivos y del estrés: inteligencia emocional y afrontamiento
Authors: Delhom Peris Iraida , Donio-Bellegardeb Mônica , Mateu-Mollá Joaquín , Lacomba-Trejo Laura
Published: July 2022

Marco teórico: La Inteligencia Emocional (IE), las estrategias de afrontamiento y la edad parecen jugar un papel importante en la aparición de sintomatología ansiosa, depresiva y de estrés, siendo todos ellos síntomas con una gran prevalencia y repercusión en España. Es por ello que estas variables se convierten en aspectos clave a considerar en relación a la salud mental. Por ello, el objetivo de este trabajo pretende comprobar si las habilidades de IE, el afrontamiento y la edad resultan predictores significativos de la psicopatología.

Método: Participaron 256 españoles, evaluados en sintomatología ansiosa, depresiva y estrés (DASS-21), IE (TMMS-24) y afrontamiento (CAE). Se llevaron a cabo correlaciones de Pearson y modelos de regresiones jerárquicas (MRJ).

Resultados: Los MRJ evidenciaron que una menor edad, menos claridad y altos niveles en atención, expresión emocional y autofocalización negativa predicen la ansiedad y el estrés, mientras que la depresión estuvo predicha por una alta atención y autofocalización y una baja claridad.

Conclusiones: Señalamos la relevancia de la IE y el afrontamiento orientado a las emociones en la predicción de la psicopatología.
Impacto psicológico del confinamiento domiciliario en mujeres con y sin TCA
Authors: Aracil Bellot Marta , Solano Santos , Lacruz Tatiana , Álvarez Tamara , Pastor Judith , López Mª Paz
Published: July 2022

La situación de pandemia sanitaria mundial que actualmente vivimos y las medidas tomadas para su alivio, como el confinamiento domiciliario, son unas situaciones que, por su carácter extraordinario, son proclives a causar un impacto psicológico en las personas, especialmente si éstas son más vulnerables al estar sufriendo un trastorno de salud mental, como en el caso de los Trastornos de la Conducta Alimentaria. En consecuencia, el objetivo de este trabajo es el de estudiar cómo puede afectar dicho confinamiento domiciliario a personas con este diagnóstico, y si les afecta de manera diferente respecto a la población general. Para ello, durante ese período se administró un cuestionario online a dos muestras de población, formadas ambas por 50 mujeres, 100 participantes en total. La muestra de población clínica, integrada por pacientes diagnosticadas de TCA, tiene una media de edad de 29.08 (DT=7.86) y la muestra de población general tiene una media de 31.60 (DT=7.63). El cuestionario incluye variables socioeconómicas, emocionales y psicológicas, y un cuestionario de autocompasión (SCS). Los resultados han mostrado un afrontamiento significativamente peor de los estresores por parte de las personas con TCA frente al grupo control, aunque no un aumento significativo de la sintomatología psicológica. Asimismo, dos variables se han mostrado muy relevantes de cara a mejorar la experiencia de próximos confinamientos, la convivencia y la autocompasión.
Cáncer de mama tratado con trastuzumab: un análisis bibliométrico de estudios latinoamericanos
Authors:   , Carrera Sanchez Jhosselyn Pamela , Robles De La Sota Lizbeth Sara
Published: July 2022

El presente estudio de investigación tiene como objetivo determinar la producción científica en países de Latinoamérica acerca del Cáncer de mama tratado con trastuzumab, teniendo en cuenta que es el tumor más prevalente en las mujeres latinoamericanas al igual que los subtipos más agresivos como Her2 en contraste con Norteamérica y Europa, según GLOBOCAN 2020. Siendo un estudio descriptivo transversal mediante el análisis bibliométrico de los artículos indizados en la revista SCOPUS durante los años 2010 – 2020. La estrategia de búsqueda para Scopus fue conformada por cuatro baterías de búsqueda, donde se evidenció 67 estudios siendo Brasil (37.31%) y México (16.42%) los países con más estudios publicados. Así mismo, se observa que el sexo femenino tiene mayor producción científica respecto al sexo masculino. Por otro lado, se encontró que las universidades fueron la principal filiación de los autores principales de nuestro estudio bibliométrico, los 2 diseños más frecuentes fueron los observacionales y experimentales, y el idioma que se encontró en la mayoría de los estudios fue inglés, seguido por español y portugués. En conclusión, el análisis bibliométrico, nos indica que la producción científica se ve muy aglomerada en Brasil, México y Chile. Se encontró que la producción de estudios experimentales y ensayos clínicos en Latinoamérica es baja, por otro lado, se evidenció un aumento del sexo femenino como autoría principal. Objetivo general: Describir las características bibliométricas sobre estudios de cáncer de mama HER2 temprano y avanzando, tratado con trastuzumab en Latinoamérica.
U-Slotted Wideband Microstrip Patch Antenna for Ka Band and mmW 5G Applications
Authors: Borel Touko Tcheutou Stephane , Priyadarshini Rashmi
Published: July 2022

5G stands for 5 th generation network. It allows to connect people, machines, objects, etc. this paper will be talking about the design of a simple rectangular microstrip patch antenna for Ka bands and mmW applications at 35 GHz as operating frequency with dimensions 4.4 x 3.05 mm2 and we got after simulation some parameters such as bandwidth equals to 4 GHz, 5.3 dB as Gain, 6.5 dB as Directivity, 1.9 as VSWR (Voltage Standing Wave Ratio). Then, we have tried to improve those parameters by doing another design known as U slot antenna and we have achieved, bandwidth equals to 3 GHz, 6.08 dB as Gain, 7.16 dB as Directivity, 1.3 as VSWR. The proposed antenna has been made using FR4 material for substrate and has successfully improved the values of parameters because efficiency is 85% and is suitable for 5G applications.
Bipolar fuzzy soft filter and its application to multi-criteria group decision-making
Authors: Demir İzzettin , SALDAMLI Murat , OKURER Merve
Published: July 2022

In this paper, firstly, we introduce the notion of a bipolar fuzzy soft filter ( BFS -filter) by using bipolar fuzzy soft sets. Also, we define the concept of an ultra BFS -filter and investigate some of its properties. Next, we give convergence of BFS -filters in a bipolar fuzzy soft topological space with useful results. Moreover, we develop a multi-criteria group decision-making method based on BFS -filter to deal with uncertainties in our daily life. Finally, we present a numerical example to make a decision for selection of best alternative.2010 AMS Classification: 54A20, 54A40, 06D72.
The incidence of venous thromboembolism among hospitalized COVID-19 positive patients: A multicenter study
Authors: Alshahrani Asma , Almoahzieie Abdullah , Alshareef Hanan , Alammashm Buthinah , Alhumaidi Sarah , Meraya Abdulkarim M. , Alshammari Abdullah S. , Ajlan Aziza , Alghofaili Alnajla , Alnassar Abdullah , Alshahrani Nada , Aldossari Maram , Alkhaldi Turkiah , Alwazzeh Marwan J , Alkuwaiti Feras A. , Almashouf Abdullah B. , alghamdi Shrouq Hamed , Alshehri Ohuod
Published: July 2022

Background
Coagulation disorders are frequently encountered among coronavirus disease 2019 [COVID-19]-infected patients, especially among those with more severe symptoms. This study aims to determine the incidence and risk factors of venous thromboembolism [VTE] in COVID-19 patients.
Methods
The retrospective observational Cohort study was conducted from March to July 2020. All adult patients [> 18 years old] with laboratory-confirmed COVID-19 were included. Laboratory data and real-time reverse transcriptase-polymerase chain reaction [rRT-PCR] for SARS-CoV-2 were obtained from medical records and correlated with those who developed VTE.
Results
In this study, 1024 patients were identified with confirmed COVID-19, of which 58 patients [5.7%] had VTE. In the bivariate analysis, VTE was associated with chronic kidney disease, hematological disorder, cancer, and high D-dimer > 0.50 mg/l. The analysis of the data showed that the number of patients diagnosed with cancer was significantly higher in the VTE group [8 patients, 13.8%] than the non-VTE group [47 patients, 4.9%; p = 0.003]. Patients with cancer were 2 times more likely to have VTE [adjusted odds ratio [1] = 2.614; 95% CI=[1.048–6.519]; p = 0.039]. The sensitivity analyses showed that individuals with high D-dimer > 0.50 mg/l were more likely to have VTE.
Conclusion
VTE is more prevalent among individuals with chronic conditions, including cancer. Healthcare professionals should closely monitor individuals with high risk of developing VTE, including those with COVID-19 and chronic conditions, to prevent unwanted complications.
Effect of central venous catheter dressing replacement frequency on skin bacterial colonization: a study protocol for a multicenter randomized controlled study
Authors: wang wenchao , Gu ying , Shen Weijie , wang Linjuan , Lin Jianping , Zhao yaoxun , Yan weili , Dou yalan , He leiyan , Lu guoping , wang chuanqing
Published: July 2022

Background: Bloodstream infections of central venous catheters （CVC） are often caused by the migration of organisms from the insertion site or under the dressing. According to the evidence summary, it is recommended to change the dressing 24hrs after insertion, which would cause central line-associated bloodstream infection (CLABSI) and medical adhesive-related skin injury (MARSI) in the previous audits we had implemented. The purpose of this study is to evaluate the hypothesis that not changing the dressing after 24hrs of CVC insertion is not inferior to changing after 24 hrs in terms of the occurrence of bacterial colonization on the seventh or eighth day after the insertion.Method: A multicenter prospective randomized controlled non-inferiority trial of pediatric patients with CVC whether the dressing is changed 24hs after CVC insertion. A total of 280 children will be enrolled according to the inclusion and exclusion criteria. The main outcome will be the occurrence of bacterial colonization under dressings. The secondary outcomes will be the incidence of CLABSI and MARSI. Discussion: This study investigates the safety and feasibility of not changing the dressing after 24hs of CVC. The result may update the evidence of CVC maintenance and form a new policy and process of CVC maintenance.Trial registration: ClinicalTrials.gov, NCT04806776. Initially registered on 17th March 2021,the recruitment will be completed on June 1st ,2022.
Acute expression of human APOBEC3B in mice causes lethality associated with RNA editing
Authors: Vega Alicia Alonso de la , Temiz Nuri , Tasakis Rafail , Somogyi Kalman , Reuveni Eli , Ben-David Uri , Stenzinger Albrecht , Poth Tanja , Papavasiliou Fotini , Harris Reuben , Sotillo Rocio
Published: July 2022

RNA editing has been described to promote heterogeneity leading to the development of multiple disorders including cancer. The cytosine deaminase APOBEC3B is known to fuel tumor evolution through DNA mutagenesis, but whether it may also function as an RNA editing enzyme has not been studied. Here, we engineered a novel doxycycline-inducible mouse model of human APOBEC3B-overexpression to understand the impact of this enzyme in tissue homeostasis and address a potential role in C-to-U RNA editing. Elevated and sustained levels of APOBEC3B led to rapid alteration of cellular fitness, major organ dysfunction, and ultimately lethality in mice. Importantly, extensive analyses of RNA-sequencing and WES from mouse tissues expressing high APOBEC3B levels reveal frequent UCC-to-UUC RNA editing events mainly localized in a specific hotspot. This work identifies, for the first time, a new function for APOBEC3B in RNA editing and presents a valuable preclinical tool to understand the emerging role of APOBEC3B as a potent driver of cancer and other diseases.
The m6A demethylase FTO promotes esophageal cancer progression via the YTHDF1/AKT3 signaling network
Authors: Zang Chunbao , Wei Ran , Zhao Fangfang , Li Zhenyu , Kong Lingsuo , Li Yuanhai
Published: July 2022

As the most abundant modification in eukaryotic messenger RNAs (mRNAs), the N6-methyladenosine (m6A) plays vital roles in many biological processes. Here we applied the methylated RNA immunoprecipitation sequencing (MeRIP-seq) and transcriptomic RNA sequencing (RNA-seq) to screen the m6A targets in esophageal cancer patients. We found that the m6A demethylase FTO was significantly up regulated in esophageal cancer cell lines and patient tissues. In vivo and in vitro assays demonstrated that FTO was involved in the proliferation, migration, invasion, and apoptosis of esophageal cancer cells. Moreover, we found that the m6A methyltransferase METTL14 negatively regulates FTO function on esophageal cancer progression. By using transcriptome-wide m6A-seq and RNA-seq assays, we identified that AKT3 is a downstream target of FTO, which acts in concert to regulate the tumorigenesis and metastasis of esophageal cancer. All these findings revealed insights into the m6A-regulated tumorigenesis in esophageal cancer, which is applicable for designing new therapeutic strategy.
The impact of elevated liver enzymes and intrahepatic cholestasis of pregnancy on the course of COVID-19 in pregnant women
Authors: denizli Ramazan , Sakcak bedri , Farisoğulları nihat , Peker melis ece Men , Sınacı selcan , Kara özgür , Tanaçan atakan , Tekin özlem Moraloğlu , Şahin dilek
Published: July 2022

Objective:This study aims to investigate the perinatal outcomes in COVID-19 pregnant women with intrahepatic cholestasis of pregnancy (ICP) and elevated liver enzymes.Methods: Present study was carried on pregnant women with COVID-19 between March 11, 2020 and August 11, 2021. Patients with liver enzyme levels higher than twice the upper limit of the reference range for Aspartate Aminotransferase (AST) and/or Alanine Transferase (ALT) were included. Cases with elevated Fasting Biliary Acid (FBA) levels were regarded as ICP. Remaining cases were used as the control group. A receiver operating characteristics (ROC) analysis was performed to assess the predictive value of ALT and AST for ICP.Results: There were a total of 1751 patients in the study period. Among them 126 had elevated liver enzymes. Nineteen of these cases had also ICP. AST and ALT values were statistically higher in the ICP group. Demographic features, clinical characteristics and perinatal outcomes were similar between the groups. The rate of ICP in pregnant women with COVID-19 was similar to the literature in this study. Although the rates of preterm delivery were higher than the current literature for both groups, study and control groups were comparable in terms of preterm delivery. The optimal cut-off values were 109.5 IU/L (specificity: 59.2%, sensitivity: 63.3%) and 89.5 IU/L (specificity: 68.4%, sensitivity: 67.3%) for ALT and AST ,respectively according to the results of the ROC analysis.Conclusion: Similar perinatal outcomes were observed between the ICP and control groups. However, relatively higher rates of maternal mortality, intensive care unit admission, neonatal intensive care unit admission, and preterm birth were observed for COVID-19 pregnant women with elevated liver enzymes compared to the previous literature. Thus, physicians dealing with pregnant women with COVID-19 should be cautious about the management of cases with elevated liver enzymes.
Infectious clone development of a recombinant strain of cucurbit aphid-borne yellows virus from Brazil by Gibson Assembly
Authors: Costa Thiago Marques , Brandt Lizandra Costa Pereira , Maachi Ayoub , Nagata Tatsuya
Published: July 2022

In Brazil, the main viral disease of the melon crop is severe yellowing disease called “Amarelão do Meloeiro”, and a polerovirus, cucurbit aphid-borne yellows virus (CABYV) is considered one of its etiological agents. This virus is a recombinant strain originated from CABYV and unknown polerovirus. Due to unsuccessful mechanical inoculations of CABYV to host plants, the study of its biological characterization is hampered. Therefore, an infectious clone of the recombinant strain of CABYV was constructed using the Gibson Assembly technology in this study. The full-length genomic cDNA clone produced here was shown to be infectious in cucurbit species such as melon, squash and West Indian gherkin plants, but not for watermelon, cucumber and zucchini plants. This insusceptibility of watermelon plants to the infectious clone corroborates the absence of this virus occurrence in watermelon fields often located near by the melon plantations. This infectious clone provides the important tool for future study in developing resistant melon variety to CABYV infection.
Effect of sarcopenia on liver cirrhosis with complicating esophageal and gastric varices after endoscopic therapy
Authors: hao ningbo , Zhou Ying , Li Xue , Zhang Dan , Hu Wen-Wei , Xie Jing , Ma Xiaobing , Tian Tian , Li Chang-Zheng
Published: July 2022

Background: Several investigators have reported that sarcopenia is common in patients with cirrhosis. However, few studies have discussed the association between sarcopenia and liver cirrhosis complicated with esophageal and gastric variceal bleeding (LC-EGVB). We aimed to investigate the impact of sarcopenia on rebleeding after endoscopic therapy in patients with LC-EGVB. Method: CT images from the 3 rd lumbar vertebrae were selected to analyze body composition, including SMT VAT and SAT, by SliceOmatic software. Sarcopenia was defined according to validated cutoff values for patients with cirrhosis: 44.77 cm 2 /m 2 for males and 32.50 cm 2 /m 2 for females. Results: A total of 187 LC-EGVB patients and 309 donors were included. The rate of sarcopenia in donors (17.4%) was significantly lower than that in LC-EGVB patients (41.2%). LC-EGVB patients with sarcopenia have a high prevalence of portal vein thrombosis and rebleeding rate at 1 year. The rate of sarcopenia in the rebleeding group was significantly higher than that in the non-rebleeding group. Univariate and multivariate analyses showed that sarcopenia was an independent risk factor for rebleeding within 1 year in LC-EGVB patients. Conclusion: LC-EGVB patients have a high prevalence of sarcopenia. Sarcopenia is an independent risk factor for rebleeding within 1 year.