bluuebunny/crossref_metadata_2025 huggingface dataset:
ОБҐРУНТУВАННЯ ТЕХНОЛОГІЇ СИРКОВИХ ПАСТ ІЗ СУБЛІМОВАНОЮ ДИНЕЮ
Authors: Синенко Тетяна Павлівна , Фещенко Дар’я Ігорівна
Published: February 2025

Сирні продукти, отримані шляхом додавання в сир кисломолочний рослинних компонентів, є дуже корисними продуктами. Оскільки рослинна сировина є джерелом незамінних амінокислот, має імуномодулюючі функції, сприяє засвоєнню жиророзчинних вітамінів і переносу заліза в організмі людини. Для зниження ризику впливу активної кислотності, додаткового зволоження готових виробів від свіжих ягід і фруктів, можливе додавання в сирну масу плодово-фруктових порошків, отриманих методом сублімації. Метою роботи є розробка технології сиркових паст з підвищеною харчовою цінністю. Для досягнення даної цілі було визначено можливість використання порошків сублімованої дині в рецептурі сиркових паст. Хімічний склад сублімованих порошків дині представлений значним вмістом рослинного білку (8,35±1,0 г/100 г). Комбінування білка рослинного і тваринного походження дозволить досягти максимальної біологічної цінності розробленого збагаченого продукту, а також оптимального амінокислотного складу кисломолочного продукту. Високий вміст харчових волокон (10,0±1,0 г/100 г) придають функціонально-технологічні властивості порошкам дині. На підставі проведених комплексних досліджень випливає, що прийнятною дозою внесення порошку сублімованої дині в сиркову пасту є від 5,0% до 20%. Органолептична оцінка в сукупності із фізико-хімічними показниками показала, що раціональним рішенням є внесення в кількості 15%. Рецептурна композиція сиркової пасти має наступний склад: 62% кисломолочного сиру (з лактулозою), 23% вершків, 15% порошку сублімованої дині. Використання порошків сублімованої дині в технології сиркових паст сприяє збільшенню калорійності за рахунок збільшенню вмісту вуглеводів, які присутні в рослинній сировині, без додавання цукру в рецептурі. Позитивним є збагачення продукту харчовими волокнами, що відповідає 6% від добової норми. Розроблено рецептуру та технологічну схему сиркових паст з підвищеною біологічною цінністю. Отримано комплекс даних, що характеризує якість розроблених паст, доведено їх харчову та біологічну цінність.
Agronomic Evaluation of Castor Bean Cultivation (Ricinus communis L.) Under Soil Moisture-Limiting Conditions
Authors: Pimentel-López J. , Salmerón-Bello D. , Ruiz-Vera V. M. , Méndez-Gallegos S. J.
Published: February 2025

Objective: To assess yield and growth responses of castor bean collections under soil moisture-restricted conditions.
Design/methodology/approach: The study was conducted in the municipality of Salinas de Hidalgo, San Luis Potosí. Twenty castor bean collections were evaluated under rainfed conditions and irrigation at 50% of crop evapotranspiration, with treatments arranged in randomized blocks.
Results: Significant differences (α = 0.05) between collections were observed for variables such as stem diameter, plant height, number of clusters per plant, number of fruits per cluster, 100-seed weight, and aerial biomass. Regarding soil moisture levels, variables including stem diameter, plant height, number of branches, number of leaves, number of clusters, number of fruits per cluster, 100-seed weight, seed yield, and aerial biomass showed significant differences (α = 0.05).
Limitations on study/implications: The results are based on a single production cycle.
Findings/conclusions: The Calvillo and Encarnación de Díaz collections showed the highest seed yields under rainfed conditions, with 385 and 326.7 g/plant, respectively, while the Luis Moya collection exhibited the highest yield under irrigation, with 680.7 g/plant. Seed yield was influenced solely by soil moisture, independent of collection origin. Collections under the most restrictive soil moisture condition (rainfed) flowered and fruited slightly earlier.
The Real Causes of Ecclesiastical Schism
Authors: Tinikashvili David
Published: February 2025

The Christian teaching during the apostolic era was founded on simple ideas, the acknowledgment of which designated an individual as a member of the church. Christians with divergent views or those who had distanced themselves from the apostles for various reasons were not deemed outside the church. But how these Christians were perceived changed throughout time. They were labeled as heretics, schismatics, and members of illegal congregations, for whom suitable regulations for reunification were instituted. Church schisms were sometimes instigated by personal aspirations such as arrogance, suspicion, distrust, and a lust for power. But even though the human aspect was important, it was rarely the only factor that caused division, which was frequently linked to other objective reasons, for example misunderstandings of a linguistic origin. Nationalism may also be attributed a significant part among the causes of religious division. German nationalism was indeed linked to the emergence of the Reformation. The organization of the Church of England is intricately linked to the class division paradigm of English society. Identical reasons are evident in earlier centuries, particularly in the founding of the Christian churches in Armenia and Persia.
THE HISTORY OF THE AL-JARKHAJI INSTITUTION IN BAGHDAD
Authors: Topuridze Irakli
Published: February 2025

The purpose of this article is to review the institution of Al-Jarkhaji (Al-Charkhachi), or the Night Watchman, in the heritage of Baghdad and the whole of Iraq. What was Al-Jarkhaji? The term is of Turkish (Ottoman) origin (جرخه جي), which means a guard, a watchman. In Iraqi reality, Al-Jarkhaji appeared to us as a night watchman, whose duty was to patrol the city streets on foot and maintain order. In the 18th-19th centuries, it was a kind of police unit that operated independently of other police, Janissary, and Mamluk units. The predecessors of al-Jarkhaji appeared on the scene as early as the reign of the four righteous caliphs. The term denoting them was “al-‘asasu” (العَسَسُ), which is also found in Georgian reality in the 17th-18th centuries. The institution of “asas” is found in medieval Georgia (mainly in eastern Georgia). In addition to the semantic similarity of the term, its practical meaning is also identical.
The Golden Age of Jewish Culture
Authors: Guledani Lali
Published: February 2025

In the Middle Ages, when the political center of Muslim Spain was first Seville and later Córdoba, a way of life and institutions characteristic of an Islamic state were established in Spain. The lifestyle of Muslim Spain, suitable for a highly developed country, and the successful adaptation of Jews to it led to the flourishing of Jewish culture and literature in Arabized Spain, which spans the 8th to the 12th centuries. Jewish literature of the period called the Golden Age; was greatly influenced by Arabic and was distinguished by its thematic and genre diversity. Romantic lyricism is widely represented in Andalusian poetry.

The favorite themes of Andalusian poets also include motifs of friendship, wine, and revelry, to which both Arab and Jewish poets dedicated their poems.

At the end of the 11th century, the genre and stylistic features of Jewish secular poetry were finally established in Andalusia. During the heyday of Jewish poetry, along with traditional Eastern Arabic genres, new, innovative genres and themes adapted to the existing reality emerged, vividly conveying the moods, feelings, and emotions of Jewish poets. Themes such as homeland and the issue of belonging to it, “Elegy for the Cities,” or longing (“Hanin”) became prevalent. Longing for the homeland was considered the most common theme in Andalusian poetry. One of the significant innovations was that Jewish poets began to write secular poems alongside traditional liturgical poetry.

The article presents the poets of the Andalusian Golden Age of Jewish culture (Yehuda Halevi, Shelomo ibn Gebirol, Moshe ibn Ezra, Abraham ibn Ezra, Shmuel Hanagid, Yehuda Alkharizi, and others), notes their merits and creative features and discusses the innovative genres and themes characteristic of this period.
Anatomy of Miracles in Medieval Georgia (According to European Narratives)
Authors: Javakhishvili Manana
Published: February 2025

The research focuses on the anatomy of medieval miracles, highlighting the miracles mentioned about Georgia in European sources, particularly in the texts of Hayton, Marco Polo, John Mandeville, Hildesheim, Plano Carpini, and Marino Sanudo.

During the 11th and 12th centuries, Latin-language sources about Georgia primarily provided general information along with semi-mythical and legendary narratives. However, in the subsequent period of Mongol rule during the 13th and 14th centuries, accounts of Georgia began to take on more concrete details. These narratives clarified the political context, landscape, customs, and other cultural-anthropological references, including descriptions of miraculous events.

The objective of this study is to analyze the nature and character of miracles that occurred in Georgia as presented in Western sources, as well as the types of interpretations these texts allow.
War in Sudan: A Sample of Regional and International Actors' Relations
Authors: Gureshidze Simon
Published: February 2025

The ongoing conflict in Sudan, particularly since April 2023, has drawn attention due to its intricate interplay of internal and external actors with diverse interests. Domestically, key players include the Sudan Armed Forces (SAF) and Rapid Support Forces (RSF), whose violent clashes have destabilized the nation and displaced thousands. The SAF, led by General Abdel Fattah al-Burhan, aims to centralize authority, while the RSF, under General Mohammed Hamdan Dagalo (Hemedti), seeks political dominance backed by revenue from resource networks. Internationally, the conflict reflects complex geopolitical dynamics. Egypt strongly supports the SAF, prioritizing stability and border security. The United Arab Emirates (UAE) and Saudi Arabia exhibit divergent strategies despite shared regional interests. Russia, through entities like the Wagner Group, pursues influence over Sudan’s natural resources and strategic positioning, while Turkey emphasizes economic, political, and military cooperation. Israel’s involvement aligns with its broader regional security interests and normalization efforts. The UK, maintaining historical ties, supports humanitarian aid and a transition to civilian governance. The Sudan conflict underscores the prioritization of financial and strategic interests over ideological concerns by regional and global powers. This multifaceted crisis reveals evolving alliances and competitive policies in a fragmented post-Cold War world.
Akeldama - Manifestation of Semantic Transformation of the Biblical Term
Authors: Elizbarashvili Eliso
Published: February 2025

The article discusses the word აკელდამა/აკლდამა [Akeldama/Akldama], which likely entered Georgian via Greek (Ἀκελδαμά or variant Ἀκελδαμάχ), and its semantic evolution. The term itself originates from the Aramaic phrase חקל דמא (Ḥaqel D'ma), translated as "Field of Blood", as attested in the Gospel of Matthew and the Acts of the Apostles (Gr. χωρίον αἴματος, ἀγρὸς αἴματος; Lat. ager sanguinis). However, this word did not gain wider usage in Greek and remained limited to its specific biblical context. In contrast, in Georgian აკლდამა [Akldama] became a designation of an honorable burial site, despite its association with Judas Iscariot’s sin, as it refers to the land purchased with the thirty pieces of silver. The article explains this transformation in the semantic meaning of აკელდამა [Akeldama] by referencing the burial tradition for pilgrims at the site known by this name in Jerusalem. This tradition would have been well-known to Georgians of the time through their compatriots in Jerusalem’s spiritual centers. In the 12th century, members of the Hospitaller Order, the Knights of St. John, built a large underground vaulted structure, which they called Chaudemar - a distorted form of the French words Champ de Mar (Field of Blood), as Akeldama is referred to in the Acts of the Apostles. This event further influenced the semantic evolution of the word აკელდამა/აკლდამა (Akeldama/Akldama) in Georgian, leading to its complete inversion of meaning—from symbolizing the sin of Judas to representing a prestigious burial structure.
Hiệu quả và an toàn của bóng Scoring trong chuẩn bị tổn hương mạch vành vôi hóa trước khi đặt stent phủ thuốc kết quả theo dõi sau 1 năm
Authors: Nguyễn Minh Khoa , Nguyễn Thế Phương , Phạm Công Nhựt , Huỳnh Văn Thưởng
Published: February 2025

Đặt vấn đề: Tổn thương vôi hóa trung bình và nặng là thách thức lớn trong can thiệp mạch vành qua da, liên quan đến nguy cơ biến cố tim mạch cao. Bóng Scoring giúp cải thiện hiệu quả chuẩn bị tổn thương, nhưng dữ liệu về tính hiệu quả và an toàn lâu dài còn hạn chế.

Mục tiêu: Đánh giá tỉ lệ biến cố tim mạch 1 năm sau can thiệp tổn thương vôi hóa bằng bóng Scoring.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu can thiệp lâm sàng không ngẫu nhiên, tiến cứu theo dõi 1 năm trên 30 bệnh nhân tổn thương vôi hoá (trung bình và nặng), sử dụng bóng Scorflex NC để chuẩn bị tổn thương trước khi đặt stent.

Kết quả: Tuổi trung bình là 60,50 ± 7,75 tuổi; 76,7% là nam giới. Đau thắt ngực không ổn định chiếm 40%. IVUS (siêu âm nội mạch) cho thấy tổn thương nặng có cung canxi lớn hơn tổn thương trung bình (282 ± 72,23o so với 220 ± 69,62o,

p = 0,009) và dài hơn (15,18 ± 9,18 mm so với 8,15 ± 4,78 mm, p = 0,01). Tỉ lệ thành công thủ thuật đạt 100%. Sau 1 năm, LDL giảm từ 3,14 ± 0,93 mmol/L xuống 2,65 ± 0,88 mmol/L (p = 0,028). MACEs (biến cố tim mạch gộp) chiếm 6,7% với tái hẹp trong stent là 6,7%, không ghi nhận tử vong do tim mạch, nhồi máu cơ tim chung hoặc huyết khối stent.

Kết luận: Bóng Scoring là phương pháp tiềm năng, an toàn, hiệu quả trong chuẩn bị tổn thương vôi hóa. Cần có thêm các nghiên cứu lâm sàng đối chứng và phân tích chi tiết các yếu tố ảnh hưởng.

Từ khóa: bóng cắt; xơ vữa mạch vành; động mạch vành; tổn thương mạch vành
Nhận thức của sinh viên Điều dưỡng về Kỳ thi lâm sàng theo Cấu trúc Khách quan (OSCE): yếu tố đảm bảo chất lượng theo Hướng dẫn của AMEE
Authors: Lê Ngọc Tuyết , Phạm Dương Thanh Tâm , Trần Thuỵ Khánh Linh , Huỳnh Thuỵ Phương Hồng , Phạm Lê An
Published: February 2025

Đặt vấn đề: Kỳ thi lâm sàng theo Cấu trúc Khách quan (OSCE) là phương pháp toàn cầu trong đánh giá kỹ năng lâm sàng. Từ năm 2022, Bộ môn Điều dưỡng, Đại học Y Dược Thành phố Hồ Chí Minh (TPHCM), đã áp dụng Hướng dẫn số 81 của AMEE nhưng nhận thức của sinh viên về OSCE chưa được nghiên cứu đầy đủ.

Mục tiêu: Mô tả nhận thức của sinh viên Điều dưỡng về OSCE và xác định mối liên quan giữa điểm thi với các yếu tố nhân khẩu học và nhận thức của sinh viên.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 216 sinh viên Điều dưỡng năm 3 và 4 tham gia OSCE năm 2022. Bộ câu hỏi gồm 32 mục (Cronbach’s alpha = 0,872) được sử dụng, phân tích bằng SPSS 16.0 với kiểm định Spearman và t-test độc lập (p <0,05).

Kết quả: Hầu hết sinh viên đánh giá OSCE công bằng (83,3%), bao quát kiến thức và kỹ năng lâm sàng (84,3% và 88,4%) nhưng gây căng thẳng (80,1%) và sợ hãi (64,3%), liên quan đến áp lực thời gian (77,7%). Các trạm thi được đánh giá có trình tự hợp lý (77,8%), phản ánh đúng nội dung học tập (72,7%) và công bằng (67,1%). Không có sự khác biệt điểm thi theo giới tính (p = 0,81) hay dân tộc (p = 0,81). Điểm thi tương quan yếu với nhận thức về đặc tính và chất lượng OSCE.

Kết luận: Sinh viên có nhận thức tích cực về OSCE, nhưng môi trường thi và hoạt động ôn tập cần cải thiện. Phản hồi từ sinh viên là cơ sở quan trọng để nâng cao chất lượng kỳ thi OSCE.

Từ khóa: nhận thức sinh viên; OSCE; đánh giá lâm sàng
Độ chính xác của phương pháp siêu âm trong xác định vị trí đầu tận của catheter tĩnh mạch trung tâm được đặt từ ngoại biên cho trẻ sơ sinh
Authors: Nguyễn Hoàng Thạch , Bùi Thanh Liêm , Trần Nam Hưng , Trịnh Thị Thu Hà , Trương Quốc Hoàng Minh , Nguyễn Hoàng Tâm
Published: February 2025

Mục tiêu: Catheter tĩnh mạch trung tâm là phương tiện vô cùng thiết yếu trong điều trị trẻ sơ sinh, đặc biệt là trẻ non tháng nhẹ cân. Việc đầu tận catheter sai vị trí có thể gây ra các biến chứng nguy hiểm tính mạng. Nghiên cứu của chúng tôi nhằm so sánh sự tương đồng của phương pháp siêu âm xác định đầu tận catheter tĩnh mạch trung tâm đặt từ ngoại biên (PICC) cho trẻ sơ sinh khi so với X quang như tiêu chuẩn chẩn đoán.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang thực hiện tại khoa Hồi sức sơ sinh bệnh viện Nhi Đồng 2, Thành phố Hồ Chí Minh từ 05 tháng 09 năm 2023 đến 31 tháng 05 năm 2024 với 60 trường hợp đặt PICC.

Kết quả: Chúng tôi ghi nhận 60 trường hợp đặt PICC, 92,7% là trẻ non tháng và nhẹ cân. Độ tuổi trung vị của dân số nghiên cứu là 28 tuần (26 – 31); cân nặng lúc sinh trung vị là 1100 gram (850 – 1350). Có 60% PICC đặt từ chi trên và đầu, 40% PICC đặt từ chi dưới. Hệ số tương đồng Kappa giữa siêu âm và Xquang khi xác định đầu tận PICC là 0,87 (p <0,0001); với siêu âm khảo sát TMC trên hệ số tương đồng Kappa là 0,96 (p <0,0001); với siêu âm khảo sát tĩnh mạch chủ (TMC) dưới hệ số tương đồng Kappa là 0,72 (p <0,001). Độ nhạy, độ đặc hiệu, giá trị tiên đoán dương, giá trị tiên đoán âm của siêu âm lần lượt là 88,9%; 93,9%; 92,3%; 91,2%; khi xét riêng siêu âm khảo sát TMC trên là 100%; 95,7%; 92,9%; 100%; siêu âm khảo sát TMC dưới là 78,6%; 90%; 91,7%; 75%.

Kết luận: Siêu âm có thể được sử dụng để xác định đầu tận PICC, nhằm hạn chế việc sử dụng Xquang cho trẻ. Tuy nhiên, khi siêu âm gặp khó khăn, Xquang vẫn là phương pháp cần thiết.

Từ khóa: catheter tĩnh mạch trung tâm; siêu âm
AI-Driven Machine Learning for Fraud Detection and Risk Management in U.S. Healthcare Billing and Insurance
Authors: Raktim Dey  , Ashutosh Roy  , Jasmin Akter  , Aashish Mishra  , Malay Sarkar
Published: February 2025

Healthcare fraud in the United States results in billions of dollars in financial losses annually, necessitating advanced technological solutions for fraud detection and risk management. Machine learning (ML) has emerged as a powerful tool in identifying fraudulent claims, mitigating risks, and enhancing financial security in healthcare billing and insurance (Anderson & Kim, 2023). This study examines the application of supervised and unsupervised ML techniques, such as decision trees, neural networks, and anomaly detection models, to detect fraudulent patterns in insurance claims (Wang et al., 2022). By analyzing large-scale electronic health records (EHRs) and claims datasets, ML algorithms can identify suspicious activities and reduce false positives, improving fraud detection accuracy (Garcia & Lee, 2023). Additionally, predictive analytics aids in risk assessment, enabling insurers and healthcare providers to proactively manage financial fraud risks (Brown et al., 2023). Despite its advantages, ML-based fraud detection systems face challenges, including data privacy concerns, interpretability issues, and regulatory compliance (Nguyen & Patel, 2023). This research highlights the effectiveness of AI-driven fraud detection models in minimizing financial losses and enhancing operational efficiency in the U.S. healthcare sector, with future implications for explainable AI and privacy-preserving ML solutions.
Sindrome de la orina púrpura
Authors: Llamas Nieves Andrés Elías , Plaza Morales Maria
Published: February 2025

Introducción: el síndrome de la bolsa de orina púrpura es una entidad poco frecuente que consiste en un cambio en la coloración de la orina, que se vuelve púrpura en determinados escenarios: pacientes de edad avanzada o con múltiples comorbilidades, portadores de sonda vesical y en el seno de una infección del tracto urinario por determinados gérmenes. Se presenta el caso de un hombre de 83 años con cuadro clásico de síndrome de orina púrpura, con el propósito de ampliar el conocimiento revisando la literatura vigente. Caso clínico: paciente de 83 años con antecedente de hiperplasia prostática benigna, portador de sonda vesical de cuatro años de evolución, quien consulta al servicio de urgencias de una institución de salud de primer nivel de Bolívar, Colombia, por cuadro clínico de 5 días de evolución consistente en picos febriles, asociado a coloración violácea de la orina. La exploración física fue normal y los laboratorios  reportan leucocitosis, parcial de orina sugestivo de infección urinaria.  Se inició tratamiento empírico con ciprofloxacino, el paciente presentó adecuada evolución clínica con desaparición de la fiebre y recuperación de la coloración normal de la orina en aproximadamente 48 horas. Conclusión: el síndrome de la orina púrpura es una entidad cuya incidencia va en aumento debido al mayor número de pacientes portadores de sonda vesical permanente con factores de riesgo asociados. En cada caso debe individualizarse tratamiento, establecer la necesidad de instaurar antibioticoterapia y educar sobre la importancia de consultar de manera oportuna.
Precarious Residence? A study on the Impact of Restrictive Migration Policy on Migrants’ Subjective Well-Being and Stress
Authors: Jutvik Kristoffer , Holmqvist Emma
Published: February 2025

Migration policy in the Nordic welfare states is increasingly marked by restrictiveness. Although research has studied the consequences of this policy trend, there is limited knowledge about how it affects stress levels and the well-being of migrants. In this study, we examine the impact of a policy change implemented in Sweden in 2016 that resulted in the swift abandonment of permanent residence. To conduct our research, we use survey data to compare differences in self-stated levels of stress and well-being among those granted permanent residence status according to the pre-2016 policy and those granted temporary residence according to the new policy. Our findings indicate a significant difference in well-being between the two groups, with those granted temporary residence permits experiencing lower levels of well-being as well as more stress related to their own and their family members’ status. Importantly, we conclude that a lower sense of well-being is correlated with higher levels of stress connected to residence status. These results have important implications for evaluating the impact of the new migration policy in Sweden and assessing similar policy trends in other contexts.
Academic Services to Support Timely Completion of Studies: Students' Needs, Expectations, and Policy Strategies
Authors: Sutarto Sutarto , Sari Dewi Purnama , Yanto Murni
Published: February 2025

This research aims to analyze student needs, expectations, and policy strategies for improving academic services to support the timely completion of studies. The type of research used is qualitative with a case study approach. The research informants were 21 students of the IAIN Curup Postgraduate Islamic Religious Education Doctoral Program and four managers of the IAIN Curup Postgraduate Islamic Religious Education and Doctoral Study Program. Data collection techniques used semi-structured interviews. The validity of the data obtained was checked using source triangulation and analyzed using the Miles and Huberman analysis model, which consists of three stages: data condensation, data presentation, and conclusion. The research results found that students' needs and expectations to support the completion of their studies on time can be grouped into two, namely academic services carried out by lecturers and academic services carried out by education staff. To ensure they complete their studies on time, students need and expect academic services that are professional, precise, and fast. The policy strategy implemented by policymakers to support the completion of studies on time is to improve educational services to student needs and expectations by establishing quality policies.
The Efficacy of the Reading, Mind Mapping, and Sharing Learning Model in Boosting Students' Problem-Solving Skills
Authors: Ardiansyah Arief , Akbar Mukhammad Naafiu
Published: February 2025

This research is motivated by the fact that there are still many teaching practices by teachers who still apply conventional learning approaches. Therefore, this research wants to test a new learning approach that emphasizes aspects of student involvement in their active cognitive processes by using the Reading, Mind Mapping, and Sharing (RMS) learning model. The main objectives of this study include two things. First, to test the effectiveness of the RMS learning model in improving students' academic performance in the form of problem-solving abilities. Second, to see how much influence the RMS learning model has in enhancing the ability to solve these problems. This study used a quasi-experimental research design on two groups of research subjects. Data analysis was carried out using several statistical techniques, namely the independent sample t-test to test the effectiveness of the RMS learning model on problem-solving abilities and calculating the effect size value to see how much influence the RMS learning model had in influencing the increase in problem-solving skills. This study found two findings: the RMS learning model has proven effective in improving problem-solving skills and has a high influence on improving problem-solving abilities. The RMS Learning Model is a foundational strategy for educators in Islamic Religious Education to boost student cognitive engagement.
The Use of Learning Management System and Its Effect on Learning Effectiveness at State Islamic University
Authors: Anwar Rosihon , Muhyi Asep Abdul , Rudianto Apip
Published: February 2025

As a result of the research, the data regarding the application of e-learning based on the Learning Management System (LMS) at UIN SGD Bandung is a form of readiness to welcome the digitization of education, which started in 2020. The university formed an exceptional IT team called PTIPD to handle the digitization of education by applying e-learning based on the Learning Management System (LMS). This research uses a qualitative method. From the results of interviews with several lecturers at the State Islamic University Sunan Gunung Djati Bandung regarding the use of e-learning based on the Learning Management System (LMS), the most widely used applications are e-knows and Google Classroom applications, there are also other applications such as zoom applications, google meet, WhatsApp, and others. The effectiveness of LMS at UIN SGD Bandung on learning depends on how the method is applied and how well students and teachers can adapt to technology in the learning context. Based on the description above, several factors influence learning using the LMS Learning Management System to be ineffective: lack of integration between online and face-to-face components, limitations in the use of technology, restrictions on interaction in learning, poor class management, and poor teaching quality.
Exploring Songs as a Novel Tool for Enhancing Arabic and English Language Learning at State Islamic University
Authors: Erlangga Rifqi Aulia , Bahroni Bahroni
Published: February 2025

This study attempts to demonstrate the language acquisition theory, which says humans are natural learners who can learn by habituation. There is a song called Kun Fayakun, which has the same tune as Maroon 5's popular song Memories. This study examines the effectiveness of teaching Arabic simultaneously with English using that song for students. Sixty-four first-year UIN Salatiga students from Indonesia's various regions were requested to sing it in two versions, analyze the lyrics in two languages (Arabic and English), and map new vocabulary learned from the song. This study's data analysis will utilize a qualitative descriptive method based on experiment outcomes. Even though the respondents' initial English and Arabic abilities were rudimentary, with an average score of 6.5 out of 10, they stated that this multilingual popular song-based experiment provided them with a lot of information and new terminology in a pleasant and challenging way. These findings show that studying Arabic and English through popular song media can be a successful and entertaining technique for students.
Aplicación de las tecnologías del aprendizaje y el conocimiento (TAC) en la enseñanza de matemáticas para Estudiantes de Educación Superior
Authors: Velastegui-Hernández Rommel , Mayorga-Ases Leticia , Hernández-Dávila Carlos , Mayorga-Ases Maria
Published: February 2025

El presente estudio aborda la aplicación de las Tecnologías del Aprendizaje y el Conocimiento (TAC) en la enseñanza de matemáticas en la educación superior, evaluando tanto los beneficios como los desafíos asociados con su integración. Las TAC, como herramientas interactivas y recursos digitales, han demostrado tener un impacto positivo en la comprensión de conceptos matemáticos complejos, permitiendo una visualización dinámica y promoviendo el aprendizaje autónomo de los estudiantes. Sin embargo, la implementación efectiva de estas tecnologías enfrenta barreras relacionadas con la formación docente insuficiente, la falta de infraestructura adecuada y la resistencia de algunos educadores a adoptarlas. A pesar de estas dificultades, los docentes y estudiantes reconocen los beneficios pedagógicos de las TAC, especialmente en cuanto a la mejora de la comprensión, la motivación y la personalización del aprendizaje. El estudio también revela que, aunque las tecnologías permiten a los estudiantes acceder a recursos complementarios y colaborar de manera más eficiente, algunos enfrentan desafíos de adaptación debido a su familiaridad limitada con las herramientas tecnológicas. Por lo tanto, se destaca la importancia de proporcionar formación continua a los docentes y estudiantes, y de garantizar una infraestructura tecnológica adecuada para facilitar el acceso y el uso efectivo de las TAC. Finalmente, se concluye que, a pesar de los retos, las TAC tienen el potencial de transformar positivamente la enseñanza de las matemáticas, favoreciendo un aprendizaje más dinámico y accesible.
Implementasi Strategi Pemasaran Industri Rumah Tangga (IRT) Food and baverage: Studi Kasus pada IRT Kopi Buser King dan BUTERI
Authors: Purwati Titik , Prasetyo Novi Eko , Sunuyeko Nurcholis , Fatmawati Fatmawati , Hadiwijaya Munawwir , Hartatik Sri Fatmaning
Published: February 2025

Penelitian ini bertujuan untuk mengidentifikasi dan mendeskripsikan strategi pemasaran yang diterapkan oleh industri rumah tangga di wilayah Malang. Dengan menggunakan studi kasus, peneliti menggunakan pedoman wawancara dan catatan lapangan untuk mendapatkan data. Data yang terkumpul ditranskrip, direduksi, ditampilkan dan ditriangulasi agar jenuh. Temuan menunjukkan bahwa kedua industri rumah tangga tersebut masih menerapkan cara yang sangat konvensional untuk menjangkau target pelanggannya. Mereka hanya melakukan penjualan langsung di pasar tradisional dan kepada mereka yang datang ke tempat-tempat wisata setempat. Dan juga, mereka mengandalkan pemasaran dari mulut ke mulut untuk mencapai target pasar mereka. Berdasarkan temuan tersebut, peneliti ingin memberikan beberapa saran kepada beberapa pihak. Untuk subjek penelitian, disarankan untuk melibatkan generasi muda dalam mempromosikan produknya. Selanjutnya, pemangku kepentingan dan peneliti lebih lanjut diharapkan dapat mendukung industri rumah tangga tersebut baik secara material maupun non material.
ANALISIS SAND BLASTING DAN COATING KAPAL MT.SUCHAONUGNUM
Authors: Wa’addulloh Mu’izzaddin , Purwanto Purwanto
Published: February 2025

Indonesia adalah negara kepulauan dengan wilayah lautan luas dan memiliki banyak jalur perdagangan dunia. Untuk itu, moda transportasi laut perlu ditingkatkan serta dipertahankan kualitasnya dari berbagai bahaya seperti korosi. Lambung kapal merupakan daerah yang selalu terjadi kontak langsung dengan air laut sehingga membutuhkan perlindungan dan perawatan ekstra. Sandblasting adalah metode pembersihan permukaan lambung kapal dari korosi, sisa lapisan cat lama, serta bekas penempelan fouling dengan menggunakan pasir silika sebagai zat abrasive. Objek penelitian ini yaitu kapal TK. Berkat 12 di sandblasting dengan tingkat kebersihan Sa2.5. Luas area yang sandblasting mencakup 2049 m² untuk sweep blasting dan 1202 m² untuk spot blasting. Setelah sandblasting dilakukan painting yaitu proses perawatan dan perlindungan lambung kapal dari bahaya kerusakan akibat korosi dan fouling. Pada lambung kapal TK. Berkat 12 dilakukan tiga kali coating pada area BGA dengan menggunakan cat primer AC, intermediate AC, dan AF, serta dua kali coating pada area AGA menggunakan cat primer AC dan finishing AGA. Luas area coating primer AC sebesar 3251 m², intermediate AC sebesar 3223 m², AF sebesar 3223 m², dan finishing AGA sebesar 928 m². Berdasarkan hasil inspeksi pengecatan berupa pengukuran DFT diketahui bahwa hasil painting TK Berkat 12 telah memenuhi standar BKI.
PERENCANAAN STRUKTUR GEDUNG KANTOR PENGELOLA 6 LANTAI KAWASAN INDUSTRI TERPADU BATANG (KITB)
Authors: Abdussalam Ashal , Haq Faishal Nurul
Published: February 2025

Kawasan Industri Terpadu Batang (KITB) adalah salah satu pusat pertumbuhan ekonomi baru yang strategis. Namun, kawasan tersebut belum ada pembangunan gedung pengelolaan yang berfungsi untuk kantor pengelola (KITB). Sehingga, BUMN akan membangun Gedung Kantor Pengelola Kawasan Industri Terpadu Batang. Jenis struktur yang akan direncanakan menggunakan struktur beton bertulang yang tentunya berpanduan serta mengacu pada Standar Nasional Indonesia yang terbaru, yaitu SNI 2847-2019, SNI 1726-2019, SNI 1727-2020 dan SNI 2052-2017. Perencanaan dimulai dengan menentukan sistem struktur, merencanakan struktur atap, preliminary desain, perhitungan beban, memodelkan struktur dan analisis momen, perhitungan penulangan, merencanakan struktur bawa dan dilanjut merencanakan anggaran biaya (RAB) dan Time Schedule.Hasil dari pembahasan yaitu sebuah perencanaan struktur Gedung dengan spesifikasi diantaranya adalah Gedung dengan sistem rangka pemikul momen khusus (SRPMK), struktur atap baja (Baja profil / IWF), B-1 (850 x 550 mm), B-2 (700 x 500 mm), B-T (350 x 250 mm), BC-1 (500 x 350 mm), BA-1 (650 x 350 mm), BA-2 (500 x 250 mm), BA-3 (400 x 200 mm), K-1 (850 x 850 mm), K-2 (750 x 750 mm), K-L (400 x 400 mm), Dinding geser (Tebal 400 mm) dengan struktur bawah menggunakan pondasi dalam dengan menggunakan bored pile P-1 (D = 550 mm, Depth = 14,60 m), P-2 (D = 300 mm, Depth = 6,40 m) dan perencanaan anggaran biaya (RAB) serta Time Schedule.
Muti-indicator integrated assessment of coastal erosion vulnerablity in the Abandoned Yellow River Delta using geospatial approaches
Authors: Zhang Zhi , Zhou Kai , Chen Peng
Published: February 2025

Coastal erosion is the leading marine hazard in the Abandoned Yellow River Delta, and coastal erosion vulnerability assessment is essential for disaster mitigation and risk reduction. To comprehensively reflect the erosion status of the coast of the Abandoned Yellow River Delta, a ICVI index that integrates the composition of coastal dynamics(Mean tidal range, Mean significant wave height, Storm surge height), coastal morphology(Seawall Elevation, Rate of coastline change, Rate of tidal flat erosion, Coastal slope, Tidal flat width), and socioeconomic indicators(Population density, Land use, Roads, Artificial protection) was constructed. After that, the coastal erosion vulnerability assessment of the Abandoned Yellow River Delta was carried out, and the physical and socioeconomic vulnerability was calculated and then combined to create an integrated coastal vulnerability index (ICVI). The driving factors and the interactions between these factors of coastal erosion vulnerability were analyzed by using a geodetector method. The results showed that the proportions of the very high, high, medium, low, and very low vulnerability of the whole coast were 13.62%, 19.31%, 18.29%, 27.28%, and 21.5%, respectively. The very high vulnerable areas were mainly distributed in Xiangshui, Binhai, and Sheyang. The coastal erosion vulnerability generally showed a distribution pattern high in the north and low in the south. The spatial differentiation of coastal erosion vulnerability results from the synergistic effect of multiple factors such as coastal dynamics, coastal morphology, and socioeconomic indicators, among which Rate of tidal flat erosion is the dominant factor in the spatial differentiation of coastal erosion vulnerability. The interaction results showed that coastal erosion protection requires the synergistic effect of multiple measures, especially coastline protection and tidal flats erosion protection, which are the most beneficial for coastal erosion protection. The vulnerability maps developed in this study can provide reliable spatial information for the relevant authorities to formulate better erosion risk mitigation policies.
Phenotype of sickle cell disease. Correlation of haplotypes and polymorphisms in cluster β, BCL11A, and HBS1L−MYB. Pilot study
Authors: Ropero Paloma , Peral Miriam , Sánchez-Martínez Luis Javier , Rochas Sara , Gómez-Álvarez Miguel , Nieto Jorge M. , González Fernando A. , Villegas Ana , Benavente Celina
Published: February 2025

Objective/Background

Sickle cell disease (SCD) is a monogenic disease with a highly variable phenotype depending on the amount of fetal hemoglobin (HbF), the main modulator. Variation of HbF levels among patients is genetically regulated. HbF determines both the phenotype of the disease and the response to treatment with the main drug used, hydroxyurea. The efforts of the researchers have focused on discovering the genetic factors responsible for HbF variation, mainly describing the haplotypes of the β cluster and single nucleotide polymorphisms (SNPs) at three different loci: BCL11A, HBS1L-MYB, and the β-globin cluster. This study aimed to determine the possible correlation between the number of SNPs and haplotypes with higher HbF levels in a cohort of patients with SCD. A positive association could explain why certain haplotypes, such as Senegal or Arab-Indian, show higher HbF levels and less severe disease.

Methods

To test this hypothesis, the characterization of haplotypes was performed using the PCR-RFLP technique and genotyping of three SNPs representative of the three loci with the greatest association with HbF variation: XmnI (rs7482144), BCL11A (rs4671393), and HBS1L-MYB (rs9376092).

Results

We found more SNPs in haplotypes related to higher HbF than those with less HbF, although only the SNP XmnI (rs7482144) showed a statistically significant association.

Conclusion

We found a direct correlation between haplotypes and the number of SNPs. Haplotypes with higher levels of HbF and less severe phenotypes showed a higher number of SNPs. Thus, the Benin and Bantu haplotypes traditionally associated with poor prognosis showed the fewest mutated SNPs.
The effects of amyloidosis and aging on glutamatergic and GABAergic synapses, and interneurons in the barrel cortex and non-neocortical brain regions
Authors: Qu Tao
Published: February 2025

Previous studies on changes in the distribution of GABAergic interneurons and excitation/inhibition (E/I) balance in Alzheimer’s disease (AD) and aging were mainly conducted in the neocortex and hippocampus. However, the limbic system is the primary and crucial location for AD progression. Therefore, in this study, we utilized AD and aging mouse models to investigate the E/I balance and the distribution of parvalbumin (PV)- and somatostatin (SST)-expressing cells in S1BF (barrel field of primary somatosensory cortex, barrel cortex), CA1 hippocampal area and brain regions beyond the neocortex and hippocampus, including retrosplenial cortex (RSC, which is composed of RSG and RSA), piriform cortex (Pir), amygdala (BMA), and hypothalamus (DM). We discovered that amyloidosis may disrupt the alignment of excitatory pre- and postsynaptic quantities. Amyloidosis reduces the quantity of synapses and SST cells, but does not impact the counts of PV cells. By contrast, aging is linked to a decline in synapses, I/E ratios, SST and PV cells. Amyloidosis affects the S1BF and BMA, while aging may harm all studied regions, including the S1BF, RSC, hippocampus, Pir, BMA, and DM. Aging mostly affects synapses and I/E ratios in Pir, BMA, and DM, and PV and SST interneurons in the hippocampus.
Can patient self-evaluation of functional status be used for evaluation of impairment of motor function in Guillain-Barré syndrome? Mapping clinician- and patient-reported outcomes in a phase 3 study of eculizumab in Japan
Authors: Regnault Antoine , Loubert Angély , Quéré Stéphane , Lin Qun , Frick Glen , Ishida Hirokazu , Abeta Yuko , Chevrou-Severac Helene
Published: February 2025

Background and purpose

Guillain-Barré syndrome (GBS) is an autoimmune neurological disorder characterized by muscle weakness. In clinical trials, treatment benefit and disease severity are typically measured using clinician-reported outcome measures like the Hughes Functional Grading Scale (HFGS). However, patient-reported outcome measures, such as the Rasch-built Overall Disability Scale (R-ODS) may provide additional insight into the patient experience during treatment. In this study, exploratory analyses of clinical trial data were performed to investigate how existing clinician-reported outcomes and patient-reported outcomes can help to assess disease progression by providing an accurate measurement of functional status.

Methods

Data were collected as part of a phase 3 study to assess the safety and efficacy of eculizumab in patients in Japan with severe GBS. The association between HFGS score and R-ODS total centile score (linear measure of limitations; 0, most severe activity and social participation limitations and 100, no limitations) was assessed using the Spearman rank-order correlation coefficient. Threshold values of R-ODS total centile score that could differentiate between patients with an HFGS score of ≤ 1 and > 1 were determined using receiver-operating characteristic curve analyses and mapping (Rasch measurement theory). A triangulation approach was used to establish a proposed value for R-ODS total centile score equivalent to an HFGS score of ≤ 1 or > 1.

Results

Overall, 57 patients were included in this analysis. These exploratory analyses revealed good correlation between R-ODS total centile and HFGS scores. Using the Rasch model, mapping of HFGS to R-ODS scores showed a good fit. Evaluation of the R-ODS threshold that could approximate the functional motor symptom categories based on HFGS (score of 0 or 1) revealed a range of values from 60 to 80. Based on a trial sample, a threshold of 60 was found to have 100% sensitivity and 87% specificity at week 4, and 93.8% sensitivity and 77.8% specificity at week 24.

Conclusion

This study established thresholds for the R-ODS total centile score that could approximate classification of functional impairment in GBS based on the HFGS score. Given that the R-ODS reflects the patient perspective, it may be used to capture a more complete picture of GBS severity.
Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review
Authors: Ibrahim Asmaa , Yusuff Kazeem , Awaisu Ahmed , Elewa Hazem
Published: February 2025

Proton pump inhibitors (PPIs) are widely prescribed medications for the management of acid-related disorders, due to their effectiveness and favorable pharmacokinetics. However, the occurrence and severity of adverse drug reactions (ADRs) in patients using PPIs, particularly in relation to their association with CYP2C19 polymorphisms, are of great concern. This association has largely been investigated through observational studies, which have shown conflicting or weak findings. Therefore, this review aims to examine the current evidence regarding the long-term ADRs of PPIs and their link to CYP2C19 variants.
Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women
Authors: Graf Katja , Murrieta-Coxca José Martin , Vogt Tobias , Besser Sophie , Geilen Daria , Kaden Tim , Bothe Anne-Katrin , Morales-Prieto Diana Maria , Amiri Behnam , Schaller Stephan , Kaufmann Ligaya , Raasch Martin , Ammar Ramy M. , Maass Christian
Published: February 2025

Background

Pregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. Current preclinical models, including animal studies, fail to accurately replicate human pregnancy conditions, resulting in gaps in drug safety and pharmacokinetics predictions. To address this issue, we used a three-organ microphysiological system (MPS) combined with a digital twin framework, to predict pharmacokinetics and fetal drug exposure.

Methods

The here shown human MPS integrated gut, liver, and placenta models, interconnected via the corresponding vasculature. Using prednisone as a model compound, we simulate oral drug administration and track its metabolism and transplacental transfer. To translate the generated data from MPS to human physiology, computational modelling techniques were developed.

Results

Our results demonstrate that the system maintains cellular integrity and accurately mimics in vivo drug dynamics, with predictions closely matching clinical data from pregnant women. Digital twinning closely aligned with the generated experimental data. Long-term exposure simulations confirmed the value of this integrated system for predicting the non-toxic metabolization of prednisone.

Conclusion

This approach may provide a potential non-animal alternative that could contribute to our understanding of drug behavior during pregnancy and may support early-stage drug safety assessment for vulnerable populations.
Genome-wide identification of PDX and expression analysis under waterlogging stress exhibit stronger waterlogging tolerance in transgenic Brassica napus plants overexpressing the BnaPDX1.3 gene compared to wild-type plants
Authors: Yao Mingyao , Hong Bo , Ji Hongfei , Guan Chunyun , Guan Mei
Published: February 2025

The PDX gene is a key gene in the vitamin B6 synthesis pathway, playing a crucial role in plant growth, development, and stress tolerance. To explore the family characteristics of the PDX gene in Brassica napus (B. napus) and its regulatory function under waterlogging stress, this study used five PDX genes from Arabidopsis thaliana as the basis for sequence analysis. Thirteen, eight, and six PDX genes were identified in B. napus, Brassica oleracea (B. oleracea), and Brassica rapa (B. rapa), respectively. Bioinformatics study reveals high conservation of PDX subfamily genes during evolution, and PDX genes in B. napus respond to waterlogging stress.In order to further investigate the effect of the PDX gene on waterlogging tolerance in B. napus, expression analysis was conducted on BnaPDX1.3 gene overexpressing B. napus plants and wild-type plants. The study showed that overexpressing plants could synthesize more VB6 under waterlogging stress, exhibit stronger antioxidant enzyme activity, and have a more effective and stable ROS scavenging system, thus exhibiting a healthier phenotype. These findings suggested that the BnaPDX1.3 gene can enhance the waterlogging tolerance of B. napus, which is of great significance for its response to waterlogging stress. Our study provides a basic reference for further research on the regulation mechanism of the PDX gene and waterlogging tolerance in B. napus.