bluuebunny/crossref_metadata_2025 huggingface dataset:
Progress and Challenges of Messenger RNA Vaccines in the Therapeutics of NSCLC
Authors: Kiousi Eftychia , Lyraraki Vasiliki , Mardiki Georgia Lamprini , Stachika Nikolina , Damianou Aikaterini Konstantina , Malainou Christina Panagiotis , Syrigos Nikolaos , Gomatou Georgia , Kotteas Elias
Published: November 2023

The introduction of immune checkpoint inhibitors in the therapeutics of non-small cell lung cancer (NSCLC) has been a game-changer in the management of patients with lung cancer; however, challenges do exist since a non-negligible subset of patients does not respond to therapy. Various immunotherapeutic anticancer strategies have been increasingly developed in recent years, including monoclonal antibodies, adoptive T-cell therapy, and vaccines. Fueled by their rapid drug development and successful implementation during the COVID-19 pandemic, messenger RNA (mRNA) vaccines represent an emerging therapeutic approach in other fields of medicine, including oncology. Several clinical trials are currently being conducted to assess the safety and efficacy of mRNA vaccines regarding a variety of solid tumors. Combining mRNA vaccines with other immunotherapeutic approaches has also been suggested and is currently under investigation. Although, in the case of NSCLC, the investigation is still in its early stages, the initial results raise the need for clinician awareness of these promising therapies. To this end, in the present review, we aim to summarize current advances in the development of mRNA vaccines in NSCLC therapeutics and discuss pragmatic challenges regarding their drug development and the different opportunities for implementation.
Urethral Mesh Assessment in Cancer Patients
Authors: Pintican Roxana , Buckley Anne , Feier Diana , Freeman Susan
Published: November 2023

Urethral mesh placement has become a common surgical intervention for the management of stress urinary incontinence. While this procedure offers significant benefits, it is not without potential complications. This review article aims to provide a comprehensive overview of urethral mesh assessment in oncologic patients. The article explores normal magnetic resonance imaging (MRI) and computed tomography (CT) mesh appearances and highlights the pathological aspects associated with urethral mesh complications including both short-term and long-term post-operative complications. By understanding the spectrum of normal findings of urethral mesh and the possible complications, clinicians can improve patient outcomes and make informed decisions regarding urethral mesh management in this patient population.
Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review
Authors: Mesgari Hassan , Esmaelian Samar , Nasiri Kamyar , Ghasemzadeh Shabnam , Doroudgar Parisa , Payandeh Zahra
Published: November 2023

Oral squamous cell carcinoma (OSCC) is a prevalent and significant type of oral cancer that has far-reaching health implications worldwide. Epigenetics, a field focused on studying heritable changes in gene expression without modifying DNA sequence, plays a pivotal role in OSCC. Epigenetic changes, encompassing DNA methylation, histone modifications, and miRNAs, exert control over gene activity and cellular characteristics. In OSCC, aberrant DNA methylation of tumor suppressor genes (TSG) leads to their inactivation, subsequently facilitating tumor growth. As a result, distinct patterns of gene methylation hold promise as valuable biomarkers for the detection of OSCC. Oral cancer treatment typically involves surgery, radiation therapy, and chemotherapy, but even with these treatments, cancer cells cannot be effectively targeted and destroyed. Researchers are therefore exploring new methods to target and eliminate cancer cells. One promising approach is the use of epigenetic modifiers, such as DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors, which have been shown to modify abnormal epigenetic patterns in OSCC cells, leading to the reactivation of TSGs and the suppression of oncogenes. As a result, epigenetic-targeted therapies have the potential to directly alter gene expression and minimize side effects. Several studies have explored the efficacy of such therapies in the treatment of OSCC. Although studies have investigated the efficacy of epigenetic therapies, challenges in identifying reliable biomarkers and developing effective combination treatments are acknowledged. Of note, epigenetic mechanisms play a significant role in drug resistance in OSCC and other cancers. Aberrant DNA methylation can silence tumor suppressor genes, while alterations in histone modifications and chromatin remodeling affect gene expression related to drug metabolism and cell survival. Thus, understanding and targeting these epigenetic processes offer potential strategies to overcome drug resistance and improve the efficacy of cancer treatments in OSCC. This comprehensive review focuses on the complex interplay between epigenetic alterations and OSCC cells. This will involve a deep dive into the mechanisms underlying epigenetic modifications and their impact on OSCC, including its initiation, progression, and metastasis. Furthermore, this review will present the role of epigenetics in the treatment and diagnosis of OSCC.
Precision Healthcare and Interventions in Hereditary Breast and Ovarian Cancer and Lynch Syndrome
Authors: Katapodi Maria C.
Published: November 2023

Precision health refers to personalized healthcare that combines genetic and genomic sequence, protein, metabolite, and microbiome information (collectively known as “omics” information) with lifestyle, social, economic, cultural, and environmental influences to help individuals achieve optimal health and well-being [...]
Gout and Colorectal Cancer Likelihood: Insights from a Nested Case-Control Study of the Korean Population Utilizing the Korean National Health Insurance Service-National Sample Cohort
Authors: Kwon Mi Jung , Han Kyeong Min , Kim Joo-Hee , Kim Ji Hee , Kim Min-Jeong , Kim Nan Young , Choi Hyo Geun , Kang Ho Suk
Published: November 2023

Considering the global importance of both gout and colorectal cancer (CRC) as significant health issues with mutual relevance, we aimed to examine the risk of colorectal cancer in Korean patients with gout. In this nested case-control study, we used data from 9920 CRC patients and 39,680 controls the Korean National Health Insurance Service-National Sample Cohort database. Propensity score overlap-weighted multivariate logistic regression analyses, adjusted for confounders, were used to assess the odds ratio (OR) and 95% confidence interval (CI) of the association between gout and CRC. Adjusted OR for CRC were similar between patients with gout and the control group (0.95; 95% CI, 0.86–1.04; p = 0.282). However, after adjustment, subgroup analysis revealed an 18% reduction in the probability of CRC among patients younger than 65 years with gout (95% CI, 0.70–0.95; p = 0.009). Conversely, absence of an association between gout and subsequent CRC persisted regardless of sex, income, residence, and Charlson Comorbidity Index score, even among individuals aged 65 years or older. These results imply that gout may not be a significant independent risk factor for CRC among the general population. However, in patients younger than 65 years with gout, a slightly reduced likelihood of CRC was observed. Further research is necessary to establish a causal relationship between gout and CRC and to generalize these findings to other populations.
Cellular Plasticity in Mammary Gland Development and Breast Cancer
Authors: Wicker Madison , Wagner Kay-Uwe
Published: November 2023

Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current definition of cellular plasticity in the field of mammary gland biology. Following a synopsis of the evolving model of the hierarchical development of mammary epithelial cell lineages, we discuss changes in cell identity during normal mammary gland development with particular emphasis on the effect of the gestation cycle on the emergence of new cellular states. Next, we summarize known mechanisms that promote the plasticity of epithelial lineages in the normal mammary gland and highlight the importance of the microenvironment and extracellular matrix. A discourse of cellular reprogramming during the early stages of mammary tumorigenesis that follows focuses on the origin of basal-like breast cancers from luminal progenitors and oncogenic signaling networks that orchestrate diverse developmental trajectories of transforming epithelial cells. In addition to the epithelial-to-mesenchymal transition, we highlight events of cellular reprogramming during breast cancer progression in the context of intrinsic molecular subtype switching and the genesis of the claudin-low breast cancer subtype, which represents the far end of the spectrum of epithelial cell plasticity. In the final section, we will discuss recent advances in the design of genetically engineered models to gain insight into the dynamic processes that promote cellular plasticity during mammary gland development and tumorigenesis in vivo.
Homologous Recombination Repair Gene Alterations Are Associated with Tumor Mutational Burden and Survival of Immunotherapy
Authors: Ito Mamoru , Kubo Makoto , Kawaji Hitomi , Otsubo Yoshiki , Kurata Kanako , Abutani Hikaru , Suyama Mikita , Oda Yoshinao , Yoshizumi Tomoharu , Nakamura Masafumi , Baba Eishi
Published: November 2023

Background: Comprehensive genomic profiling (CGP) has become generally accepted practice in cancer care since CGP has become reimbursed by national healthcare insurance in Japan in 2019. However, its usefulness for cancer patients is insufficient for several reasons. Methods: In an observational clinical study of FoundationOne® CDx, potential biomarkers were explored and the cause of testing failure was investigated. A total of 220 cancer patients were enrolled in the study during the period from 2018 to 2019 at Kyushu University Hospital. Results: The primary tumor sites of the 220 cases were breast (115), colon (29), stomach (19), and pancreas (20). The present dataset suggested that homologous recombination repair (HRR) gene alterations were positively associated with tumor mutational burden-high (TMB-high) (p = 0.0099). A public dataset confirmed that patients with HRR gene alterations had a higher TMB and showed significantly longer survival of immunotherapy. In the present study, 18 cases failed sequencing. A lower percentage of tumor cell nuclei was the most common reason for testing failures (p = 0.037). Cases that received neoadjuvant chemotherapy before sampling tended to fail testing. Conclusions: HRR gene alterations can be a potential biomarker predicting TMB-high and a good response to immunotherapy. For successful sequencing, samples with lower percentages of tumor cell nuclei and previous neoadjuvant chemotherapy should be avoided.
Effects of Acute and Chronic Gabapentin Treatment on Cardiovascular Function of Rats
Authors: Pendyala Ved Vasishtha , Pribil Sarah , Schaal Victoria , Sharma Kanika , Jagadesan Sankarasubramanian , Yu Li , Kumar Vikas , Guda Chittibabu , Gao Lie
Published: November 2023

Gabapentin (GBP), a GABA analogue, is primarily used as an anticonvulsant for the treatment of partial seizures and neuropathic pain. Whereas a majority of the side effects are associated with the nervous system, emerging evidence suggests there is a high risk of heart diseases in patients taking GBP. In the present study, we first used a preclinical model of rats to investigate, firstly, the acute cardiovascular responses to GBP (bolus i.v. injection, 50 mg/kg) and secondly the effects of chronic GBP treatment (i.p. 100 mg/kg/day × 7 days) on cardiovascular function and the myocardial proteome. Under isoflurane anesthesia, rat blood pressure (BP), heart rate (HR), and left ventricular (LV) hemodynamics were measured using Millar pressure transducers. The LV myocardium and brain cortex were analyzed by proteomics, bioinformatics, and western blot to explore the molecular mechanisms underlying GBP-induced cardiac dysfunction. In the first experiment, we found that i.v. GBP significantly decreased BP, HR, maximal LV pressure, and maximal and minimal dP/dt, whereas it increased IRP-AdP/dt, Tau, systolic, diastolic, and cycle durations (* p < 0.05 and ** p < 0.01 vs. baseline; n = 4). In the second experiment, we found that chronic GBP treatment resulted in hypotension, bradycardia, and LV systolic dysfunction, with no change in plasma norepinephrine. In the myocardium, we identified 109 differentially expressed proteins involved in calcium pathways, cholesterol metabolism, and galactose metabolism. Notably, we found that calmodulin, a key protein of intracellular calcium signaling, was significantly upregulated by GBP in the heart but not in the brain. In summary, we found that acute and chronic GBP treatments suppressed cardiovascular function in rats, which is attributed to abnormal calcium signaling in cardiomyocytes. These data reveal a novel side effect of GBP independent of the nervous system, providing important translational evidence to suggest that GBP can evoke adverse cardiovascular events by depression of myocardial function.
C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages
Authors: Wright Oliver , Harris Anna , Nguyen Van Dien , Zhou You , Durand Maxim , Jayyaratnam Abbie , Gormley Darren , O’Neill Luke A. J. , Triantafilou Kathy , Nichols Eva Maria , Booty Lee M.
Published: November 2023

The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the specific downstream targets and underlying molecular mechanisms are less clear. In this study, CRISPR-Cas9 was used to generate macrophage models lacking C5aR2, which were used to probe the role of C5aR2 in the context of PRR stimulation. cGAS and STING-induced IFN-β secretion was significantly increased in C5aR2 KO THP-1 cells and C5aR2-edited primary human monocyte-derived macrophages, and STING and IRF3 expression were increased, albeit not significantly, in C5aR2 KO cell lines implicating C5aR2 as a regulator of the IFN-β response to cGAS-STING pathway activation. Transcriptomic analysis by RNAseq revealed that nucleic acid sensing and antiviral signalling pathways were significantly up-regulated in C5aR2 KO THP-1 cells. Altogether, these data suggest a link between C5aR2 and nucleic acid sensing in human macrophages. With further characterisation, this relationship may yield therapeutic options in interferon-related pathologies.
Sertoli Cell-Specific Activation of Transforming Growth Factor Beta Receptor 1 Leads to Testicular Granulosa Cell Tumor Formation
Authors: Fang Xin , Nie Linfeng , Putluri Satwikreddy , Ni Nan , Bartholin Laurent , Li Qinglei
Published: November 2023

The transforming growth factor β (TGFβ) superfamily, consisting of protein ligands, receptors, and intracellular SMAD transducers, regulates fundamental biological processes and cancer development. Our previous study has shown that sustained activation of TGFβ receptor 1 (TGFBR1) driven by anti-Mullerian hormone receptor type 2 (Amhr2)-Cre in the mouse testis induces the formation of testicular granulosa cell tumors (TGCTs). As Amhr2-Cre is expressed in both Sertoli cells and Leydig cells, it remains unclear whether the activation of TGFBR1 in Sertoli cells alone is sufficient to induce TGCT formation. Therefore, the objective of this study was to determine whether Sertoli cell-activation of TGFBR1 drives oncogenesis in the testis. Our hypothesis was that overactivation of TGFBR1 in Sertoli cells would promote their transdifferentiation into granulosa-like cells and the formation of TGCTs. To test this hypothesis, we generated mice harboring constitutive activation of TGFBR1 in Sertoli cells using anti-Mullerian hormone (Amh)-Cre. Disorganized seminiferous tubules and tumor nodules were found in TGFBR1CA; Amh-Cre mice. A histological analysis showed that Sertoli cell-specific activation of TGFBR1 led to the development of neoplasms resembling granulosa cell tumors, which derailed spermatogenesis. Moreover, TGCTs expressed granulosa cell markers including FOXL2, FOXO1, and INHA. Using a dual fluorescence reporter line, the membrane-targeted tdTomato (mT)/membrane-targeted EGFP (mG) mouse, we provided evidence that Sertoli cells transdifferentiated toward a granulosa cell fate during tumorigenesis. Thus, our findings indicate that Sertoli cell-specific activation of TGFBR1 leads to the formation of TGCTs, supporting a key contribution of Sertoli cell reprogramming to the development of this testicular malignancy in our model.
“Small Hepatocytes” in the Liver
Authors: Mitaka Toshihiro , Ichinohe Norihisa , Tanimizu Naoki
Published: November 2023

Mature hepatocytes (MHs) in an adult rodent liver are categorized into the following three subpopulations based on their proliferative capability: type I cells (MH-I), which are committed progenitor cells that possess a high growth capability and basal hepatocytic functions; type II cells (MH-II), which possess a limited proliferative capability; and type III cells (MH-III), which lose the ability to divide (replicative senescence) and reach the final differentiated state. These subpopulations may explain the liver’s development and growth after birth. Generally, small-sized hepatocytes emerge in mammal livers. The cells are characterized by being morphologically identical to hepatocytes except for their size, which is substantially smaller than that of ordinary MHs. We initially discovered small hepatocytes (SHs) in the primary culture of rat hepatocytes. We believe that SHs are derived from MH-I and play a role as hepatocytic progenitors to supply MHs. The population of MH-I (SHs) is distributed in the whole lobules, a part of which possesses a self-renewal capability, and decreases with age. Conversely, injured livers of experimental models and clinical cases showed the emergence of SHs. Studies demonstrate the involvement of SHs in liver regeneration. SHs that appeared in the injured livers are not a pure population but a mixture of two distinct origins, MH-derived and hepatic-stem-cell-derived cells. The predominant cell-derived SHs depend on the proliferative capability of the remaining MHs after the injury. This review will focus on the SHs that appeared in the liver and discuss the significance of SHs in liver regeneration.
General Curve Model for Evaluating Mechanical Properties of Concrete at Different Ages
Authors: Yang Qiuwei , Wang Xinhao , Peng Xi , Qin Fengjiang
Published: November 2023

During the process of pouring and solidification of concrete, the compressive strength and elastic modulus of concrete exhibit dynamic growth patterns. The mechanical properties of concrete usually remain stable in the later stage (28 days after pouring). Studying appropriate curve models to accurately evaluate the changes in early mechanical properties of concrete has always been an important topic in the field of concrete materials. This work proposes a new dual parameter curve model for accurately evaluating the growth pattern of early compressive strength and elastic modulus of concrete. A comparative study was conducted between the proposed new curve model and existing curve models using 18 sets of experimental data from 10 literature sources. The research results indicate that the fitting average error and standard deviation of this new curve model are significantly smaller than the existing curve models. For some examples, the fitting error and standard deviation of the new model are only about 20%–30% of those of the existing models. The main advantages of this new curve model lie in two aspects. The first advantage is that this new curve model only contains two unknown parameters, so only a small amount of experimental data is required for data fitting and does not require complex mathematical operations. The second advantage is that this new curve model has a wide range of applications, which include compressive strength evaluation and elastic modulus evaluation and can also be extended to the evaluation of the mechanical properties of other materials similar to concrete.
Nanoscale Insights into the Protection of Calcium Silicate Hydrate by Polydimethylsiloxane Coatings in Sulfate Environments: Different Degrees of Polymerization
Authors: Jiang Jialin , Li Shaochun , Duan Yuying , Wang Muhan , Hu Jinhu , Hou Dongshuai , Geng Yongjuan , Hu Mengjun , Liu Zhijun
Published: November 2023

Calcium silicate hydrate (CSH) plays a crucial role in concrete by controlling its properties and durability. The degradation of CSH often signifies concrete damage. Polydimethylsiloxane (PDMS) is commonly used to protect concrete from sulfate corrosion; however, the comprehensive mechanistic understanding of its protective effects against CSH remains limited. Here, molecular dynamics (MD) simulations were employed to explore atomic-scale interactions between PDMS coatings and CSH in a sulfate-rich environment. Our results reveal that PDMS mitigates sulfate-induced CSH decalcification by forming a positively charged layer, ultimately reducing sulfate bonding by 83.3% compared to the blank group. Molecular structure analysis highlights key hydrogen bonding and calcium–oxygen bonding interactions that are critical for this protection. Higher polymerization stabilizes substrate adsorption, reducing surface diffusion to 33.3% of low-polymerization PDMS, thereby enhancing protection. Additionally, water molecule interactions with the CSH matrix are negatively correlated with the amount of adsorbed sulfate. Simulation results offer valuable insights into the molecular-level dynamic response of the material, contributing to a deeper understanding of the protective mechanisms of PDMS against sulfate-induced CSH degradation in concrete. These findings can guide experimenters and engineers in designing more effective protective coatings for concrete exposed to sulfate-rich environments, thereby laying a foundation for further experimental research and the development of concrete materials with enhanced durability under challenging environmental conditions.
Effect of Ca Addition on Inclusions of Welding Heat-Affected Zone in Pressure Vessel Steels
Authors: Liu Yan , Li Bo , Wang Kai , Du Anna
Published: November 2023

Pressure vessel steels are used in the manufacture of tanks for the storage of gases, chemical materials and oil. To meet the increasing production demands, high-wire-energy welding is widely used in the manufacture of pressure vessel steels. This means that the weldability of pressure vessel steels needs to be improved. Therefore, in order to reveal the microalloying effect of Ca in pressure vessel steel, this study took a commonly used pressure vessel steel as the research object, and three groups of experimental steels with different Ca mass fractions were prepared using vacuum metallurgy, controlled rolling and controlled cooling. Welding heat simulation technology was used to simulate the welding heat of experimental steel and the welding heat-affected zone (HAZ) was investigated. The inclusions of the welding HAZ in the experimental steels were observed by using a metallographic microscope and scanning electron microscope (SEM). The mechanism of intragranular acicular ferrite (IAF) nucleation induced by the inclusions containing Ca elements in the welding HAZ of pressure vessel steels was also discussed. The research results show that the addition of Ca increased the number density of effective inclusions in the welding HAZ of the experimental steel up to 535.60 pieces/mm2. The addition of the Ca element was beneficial for producing more pinning inclusions in the experimental steel welding HAZ under the experimental conditions, and the inclusions were mainly elliptical oxide complex inclusions of Ca-Si with a size of about 2 μm. Meanwhile, Al2O3 and MnS were precipitated. After the addition of Ca elements, Mn-poor regions appeared around the inclusions containing Ca in the welding HAZ. IAF nucleation was mainly induced by the local compositional change mechanism and supplemented by the stress–strain energy mechanism and inert interface energy mechanism. This study provides a valuable reference for optimizing the welding process of pressure vessel steels and is of great importance for understanding the IAF nucleation mechanism of Ca-containing inclusions in the welding HAZ of pressure vessel steels.
Safety and Efficacy of Concurrent Atezolizumab/Bevacizumab or Nivolumab Combination Therapy with Yttrium-90 Radioembolization of Advanced Unresectable Hepatocellular Carcinoma
Authors: Villalobos Alexander , Dabbous Howard Hussein , Little Olivia , Gbolahan Olumide Babajide , Akce Mehmet , Lilly Meghan Allegra , Bercu Zachary , Kokabi Nima
Published: November 2023

To evaluate the safety and efficacy of combining yttrium-90 radioembolization (Y90-RE) with immune checkpoint inhibitor therapy, consecutive advanced unresectable hepatocellular carcinoma (HCC) patients treated between 2016 and 2022 with atezolizumab/bevacizumab or nivolumab within three-months pre- and post-Y90-RE were retrospectively evaluated. Tumor response and treatment-related clinical/laboratory adverse events (AE) were assessed at 1 and 6 months, as well as differences in clinical and laboratory variables and median overall survival (OS) from initial treatment (whether it was Y90-RE or systemic therapy) between the two cohorts. A total of 19 patients (10 atezolizumab/bevacizumab; 9 nivolumab), comprising 84% males with median age 69 years, met the inclusion criteria. Compared to the atezolizumab/bevacizumab group, there were less males (100% vs. 67%; p = 0.02) and more ECOG ≥ 2 patients in the nivolumab group (0% vs. 33%; p = 0.02). Baseline characteristics or incidence of 6-month post-treatment any-grade AE (60% vs. 56%; p = 0.7), grade ≥ 3 AE (0% vs. 11%; p = 0.3), objective response (58% total, 60% vs. 56%; p = 0.7), and complete response (16% total; 10% vs. 22%; p = 0.8) were similar between the atezolizumab/bevacizumab and the nivolumab cohorts. Median OS was 12.9 months for the whole cohort, 16.4 months for nivolumab, and 10.7 months for atezolizumab/bevacizumab. Among patients with advanced unresectable HCC, the utilization of Y90-RE concurrently or within 90 days of nivolumab or atezolizumab/bevacizumab immunotherapy, appears to be well-tolerated and with a low incidence of severe AE.
Benefits of Morphology-Based Functional Group Classification to Study Dynamic Changes in Phytoplankton in Saline-Alkali Wetlands, Taking Typical Saline-Alkali Wetlands in Northeast China as an Example
Authors: Zhao Zhongbo , Song Tiejun , Zhang Mingye , Tong Shouzheng , An Yu , Zhang Peng , Sang Bing , Cao Guanglan
Published: November 2023

Phytoplankton are sensitive to the change in hydrological environment and can effectively reflect the health status of water, so they are often used for water quality assessment. To understand the recovery process of phytoplankton community structure characteristics and water quality conditions, two methods of phytoplankton classification functional group (FG) and morphology-based functional group (MBFG) were compared based on morphological differences and applicability. In this study, we investigated the changes in the aquatic environmental conditions and phytoplankton functional groups in the saline wetland of Dagangzipao during the restoration process of the Songnen Plain. The functional group division method suitable for saline-alkali wetlands was also determined. The results showed that there were 86 species belonging to 47 genera and seven phyla. The average phytoplankton biomass range in 2020 is 0.37 mg/L–3.59 mg/L, and the average phytoplankton biomass range in 2021 is 0.01 mg/L–1.44 mg/L. The Q-index showed that the water quality was in a good state. The redundancy analysis showed that the characteristics of phytoplankton functional groups showed a good indication of the habitat characteristics of saline-alkali wetlands, and the environmental interpretation of the MBFG was higher than that of the FG. The results provide a reference for the sustainable development of saline wetland water environment protection and ecological restoration.
Dynamics of a Quantum Common-Pool Resource Game with Homogeneous Players’ Expectations
Authors: Grau-Climent Juan , García-Pérez Luis , Alonso-Sanz Ramon , Losada Juan Carlos
Published: November 2023

In this work, we analyse a common-pool resource game with homogeneous players (both have boundedly rational expectations) and entanglement between players’ strategies. The quantum model with homogeneous expectations is a differential approach to the game since, to the best of our knowledge, it has hardly been considered in previous works. The game is represented using a Cournot type payoff functions, limited to the maximum capacity of the resource. The behaviour of the dynamics is studied considering how the fixed points (particularly the Nash equilibrium) and the stability of the system vary depending on the different values of the parameters involved in the model. In the analysis of this game, it is especially relevant to consider the extent to which the resource is exploited, since the output of the players is highly affected by this issue. It is studied in which cases the resource can be overexploited, adjusting the parameters of the model to avoid this scenario when it is possible. The results are obtained from an analytical point of view and also graphically using bifurcation diagrams to show the behaviour of the dynamics.
Experimental Study on the Effect of Carbon Graphitization Degree and Pore Structure on the Electrochemical Durability of Gas Diffusion Layers
Authors: Wang Jianan , Gao Lingfeng , Liao Tianshu , Cheng Feng , Zhou Daming , Hua Shiyang
Published: November 2023

Gas diffusion layers (GDLs) in high-temperature, high-humidity, and high-electric-potential environments can be affected by the carbon corrosion and degradation of Polytetrafluoroethylene (PTFE) network structures, resulting in reduced reliability and hydrophobicity. By using cyclic voltammetry and offline characterization, a high-potential scanning of 1–1.5 V is applied to the GDL in the three-electrode system, considering the role of gradient graphitization degree and pore size structure in corrosion. Accelerating the electrochemical corrosion process of carbon and PTFE allows the identification of corrosion location, extent, and determinants. The results indicate that after 800 cycles of high-potential triangulation scanning, the graphitization of gas diffusion base has the most significant impact on the GDL’s durability. On the other hand, the durability of the GDL’s microporous layer is influenced by its small pore size structure rather than its graphitization degree. Furthermore, the corrosion process of GDLs with a small pore size structure tends to be relatively slow, providing a basis for GDL selection and durability prediction.
The Economic Importance of Offshore Wind Energy Development in Poland
Authors: Brelik Agnieszka , Nowaczyk Piotr , Cheba Katarzyna
Published: November 2023

The European Union’s climate policy aims to reduce greenhouse gas emissions by 55% by 2030 and to achieve climate neutrality by 2050. One of the instruments for achieving these climate goals is the development of offshore wind energy. Unfortunately, Poland, as one of the few European Union countries with access to the sea, does not have offshore wind farms yet. The purpose of this article is to determine the importance of offshore wind energy for the development of Poland based on the example of two sea regions: the West Pomeranian and Pomeranian Voivodeships. This article uses the input–output method to determine the economic effects of offshore wind power. The region’s share in the supply chain was determined based on the location of the offshore wind energy sector. A comparative analysis with the Saint-Brieuc offshore wind farm in France made it possible to show the differences between the studied locations. The supply chain share of the regions surveyed was 2.28% and 6.00% in the CAPEX phase and 5.98% and 8.23% in the OPEX phase. The annual average global value in the CAPEX phase at the country level was EUR 2793 million, and at the regional level, EUR 243 million and EUR 663 million. In the OPEX phase, the corresponding values are EUR 2106 million, EUR 223 million and EUR 663 million. The average annual employment in the CAPEX phase at the national level amounted to 26,323 jobs and at the regional level, 1953 and 5804. In the OPEX phase, employment amounted to 4790, 558 and 751 jobs, respectively. On the other hand, the average annual value added in the CAPEX phase at the national level was EUR 1221 million, and at the regional level, it was EUR 106 million and EUR 290 million. In the OPEX phase, it was EUR 920 million, EUR 97 million and EUR 239 million, respectively. While not all of the findings are conclusive, in general, the domestic offshore wind industry has weaker economic linkages and lower wage levels than the location adopted for comparison. It uses more labour-intensive economic sectors with lower OPEX value added. The results of the analyses presented in this paper are of crucial importance not only for Poland, as their advantage is the possibility to present, from an economic point of view, the profitability of this type of investment in general.
A Review of the Sustainable Development of Solar Photovoltaic Tracking System Technology
Authors: Yang Zihan , Xiao Zhiquan
Published: November 2023

In the face of the traditional fossil fuel energy crisis, solar energy stands out as a green, clean, and renewable energy source. Solar photovoltaic tracking technology is an effective solution to this problem. This article delves into the sustainable development of solar photovoltaic tracking technology, analyzing its current state, limiting factors, and future trends. The adjustment of solar panel orientation using solar tracking technology to maximize energy generation efficiency has been widely implemented in various fields, including solar power plants. Currently, limiting factors for this technology include energy generation efficiency, costs, and the complexity of various environmental conditions. In terms of sustainable development, this article emphasizes the importance of photovoltaic materials and manufacturing innovation, energy efficiency improvements, as well as the integration of smart and digital technologies. Future trends include higher precision, broader applications, and lower costs. Solar photovoltaic tracking technology will play a pivotal role in global energy production, fostering the realization of a clean and sustainable energy future.
A Hybrid Physical Co-Simulation Smart Grid Testbed for Testing and Impact Analysis of Cyber-Attacks on Power Systems: Framework and Attack Scenarios
Authors: Abdelrahman Mahmoud S. , Kharchouf Ibtissam , Nguyen Tung Lam , Mohammed Osama A.
Published: November 2023

With the deployment of numerous innovative smart grid technologies in modern power systems, more real-time communication and control are required due to the complexity and proliferation of grid-connected systems, making a power system a typical cyber-physical system (CPS). However, these systems are also exposed to new cyber vulnerabilities. Therefore, understanding the intricate interplay between the cyber and physical domains and the potential effects on the power system of successful attacks is essential. For cybersecurity experimentation and impact analysis, developing a comprehensive testbed is needed. This paper presents a state-of-the-art Hybrid Physical Co-simulation SG testbed at FIU developed for in-depth studies on the impact of communication system latency and failures, physical events, and cyber-attacks on the grid. The Hybrid SGTB is designed to take full advantage of the benefits of both co-simulation-based and physical-based testbeds. Based on this testbed, various attack strategies are tested, including man-in-the-middle (MitM), denial-of-service (DoS), data manipulation (DM), and setting tampering (change) on various power system topologies to analyze their impacts on grid stability, power flow, and protection reliability. Our research, which is based on extensive testing on several testbeds, shows that using hybrid testbeds is justified as both practical and effective.
Power Generation with Renewable Energy and Advanced Supercritical CO2 Thermodynamic Power Cycles: A Review
Authors: Zhang Xinyu , Ge Yunting
Published: November 2023

Supercritical CO2 (S-CO2) thermodynamic power cycles have been considerably investigated in the applications of fossil fuel and nuclear power generation systems, considering their superior characteristics such as compactness, sustainability, cost-effectiveness, environmentally friendly working fluid and high thermal efficiency. They can be potentially integrated and applied with various renewable energy systems for low-carbon power generation, so extensive studies in these areas have also been conducted substantially. However, there is a shortage of reviews that specifically concentrate on the integrations of S-CO2 with renewable energy, encompassing biomass, solar, geothermal and waste heat. It is thus necessary to provide an update and overview of the development of S-CO2 renewable energy systems and identify technology and integration opportunities for different types of renewable resources. Correspondingly, this paper not only summarizes the advantages of CO2 working fluid, design layouts of S-CO2 cycles and classifications of renewable energies to be integrated but also reviews the recent research activities and studies carried out worldwide on advanced S-CO2 power cycles with renewable energy. Moreover, the performance and development of various systems are well grouped and discussed.
Calculation of Processes in the Electric Drive of the Sucker-Rod Pumping Unit with Reactive Power Compensation
Authors: Malyar Andriy , Cieslik Sławomir
Published: November 2023

The uneven load of the electric drive of sucker-rod pumping units causes an increase in the consumption of reactive power, which requires compensation. This article discusses the issue of calculating the processes in sucker-rod pumping units in the case of individual compensation of the reactive power. Mathematical models for calculating the process of changing the capacity of cosine capacitors for reactive power compensation in the starting and steady-state modes of the electric drive of the sucker-rod pumping unit, which are characterized by the periodically varying load and moment of inertia, have been developed. The calculation is based on a mathematical model of the induction motor that takes into account the saturation of the magnetic path and the skin effect in the bars of the deep-bar rotor. The created mathematical model can be used to regulate the capacitance of the capacitors connected to the induction motor in order to reduce the reactive power consumption.
Accuracy Assessment of Charge-Mode Accelerometers Using Multivariate Regression of the Upper Bound of the Dynamic Error
Authors: Tomczyk Krzysztof , Kowalczyk Małgorzata
Published: November 2023

This paper presents the mathematical basis and related procedures for the regression of the upper bound of the dynamic error produced by charge-mode accelerometers. The integral-square error obtained in response to simulation signals with one constraint appearing at the input of the accelerometer is considered. Physical models of accelerometers are presented with related equations and mathematical formulae that make it possible to obtain the error and the corresponding constrained signal. Examples of the regression for predefined values of the accelerometer parameters are also discussed. The solutions presented in this paper may contribute to increasing the accuracy of the charge-mode accelerometers commonly used in energy systems. Development of the functions approximating the integral-square error for the given ranges of accelerometer parameters constitutes the original contribution of this paper.
Examining the Mechanism of Current Conduction at Varying Temperatures in Polyimide Nanocomposite Films
Authors: Akram Shakeel , Haq Inzamam Ul , Castellon Jerome , Nazir M. Tariq
Published: November 2023

Charge injection and conduction are fundamental phenomena that occur in dielectric materials when subjected to both low and high electric fields. This paper delves into the exploration of various conduction mechanisms, including space-charge-limited current (SCLC), Schottky charge injection, Poole–Frenkel, and hopping charge conduction, to elucidate the prevailing conduction mechanism in single and multilayer polyimide (PI)/SiO2 nanocomposite films across a range of temperatures. At elevated electric field strengths, the conduction behavior transitions from ohmic to exhibiting a non-linear current–voltage dependence. The investigation highlights that PI nanocomposite films display distinct conduction behaviors contingent on both the applied electric field and temperature conditions. The insights derived from this study provide valuable empirical groundwork and explanations for conducting current measurements in PI-based insulation systems, particularly in applications such as motor insulation for electric vehicles.
Influencing Factors Analysis and Optimization of Hydraulic Fracturing in Multi-Layered and Thin Tight Sandstone Gas Reservoir
Authors: Zhang Hao , Bai Yuhu , Fang Maojun , Meng Fankun
Published: November 2023

With the deepening of exploration and development of tight sandstone gas reservoirs, the remaining recoverable reservoirs gradually become thinner with the vertical stratigraphic structure. The geomechanical properties become complex, and development based on conventional hydraulic fracturing methods often leads to serious problems, such as difficult control of fracture height, penetrating interlayers, too short fracture length, and inadequate proppant filling. In view of the above problems, we conducted a numerical investigation on a hydraulic fracturing scheme in a multi-layered and thin tight sandstone gas reservoir. According to the dataset from wells in a real gas reservoir in China’s Ordos Basin, the relevant geomechanical characteristics of the gas layers, together with the interlayers in the main production interval, were obtained, based on which, a fine numerical model was developed. By using the PL3D fracture propagation algorithm, a 3D hydraulic fracture propagation model was produced, and then using microseismic monitoring and production data matching, a high-precision hydraulic fracture model of the multi-layered and thin tight sandstone gas reservoir was obtained. On this basis, the influence of different geomechanical parameters and fracturing operational parameters on hydraulic fracture propagation was analyzed. Finally, an optimized hydraulic fracturing scheme that fitted the characteristics of the multi-layered and thin tight sandstone gas reservoir was proposed. Using a typical reservoir example, the optimized scheme enabled control of the fracture height in thin layers and the creation of long fractures with better proppant filling, so that the productivity of the fracture was significantly improved.
Global Decarbonization: Current Status and What It Will Take to Achieve Net Zero by 2050
Authors: Lau Hon Chung , Tsai Steve C.
Published: November 2023

A review of global CO2 emissions over the last century shows that emissions from 80 economies contributed to 95% of global emissions. Among them, 55 economies were decarbonizers, where CO2 emissions had either plateaued or were declining, while 25 economies were polluters, where CO2 emissions were still increasing. In 2021, the global CO2 emissions were 37.1 Gtpa, with 56% coming from polluters and 39% from decarbonizers. If current trends continue, global CO2 emissions will reach 49.6 Gtpa by 2050, with 81% coming from polluters and 14% from decarbonizers. Only 14 economies will reach net zero. The decarbonization target, over and above current efforts, to achieve net zero is calculated for each economy. Decarbonizers need to mitigate 230 Mtpa CO2 and polluters 1365 Mtpa CO2 beginning in 2021 to reach the net-zero target by 2050. This target will increase each year decarbonization is delayed. Analyses show that renewable energies’ share in the total final energy consumption in most economies increased by an average of only 4 percentage points in the last decade, which is inadequate for achieving net zero by 2050. Other means of decarbonization, including low-carbon fossil solutions through carbon capture and storage, will be needed. Pathways to accelerate decarbonization are proposed and their policy implications are discussed.
Whole Life Cycle Cost Analysis of Transmission Lines Using the Economic Life Interval Method
Authors: Zeng Wenhui , Fan Jiayuan , Zhang Wentao , Li Yu , Zou Bin , Huang Ruirui , Xu Xiao , Liu Junyong
Published: November 2023

With the large-scale construction and commissioning of transmission lines over the past two decades, the grid is facing a large-scale centralized decommissioning of transmission lines. The transmission line’s economic life is crucial to rationalizing its construction and reducing the grid’s development costs. Based on the minimum economic life calculation principle, the static and dynamic transmission line economic life calculation model is established, considering the whole life cycle for transmission line cost. The improved gray GM (1,1) model is applied to forecast cost data during the economic life assessment of transmission lines with fewer samples. Considering the cost uncertainty in life-cycle costing, the interval cost model based on the coefficient of variation wave amplitude is proposed to determine the economic life intervals under different guarantees by using the normal distribution probability density function, which reduces the influence of cost fluctuations on the economic life calculation error. The economic life analysis of a 500 kV transmission line is used as a case study to verify the model’s accuracy and effectiveness. The method shows the economic life intervals under different guarantee degrees based on the most probable economic life determination, which provides theoretical support for calculating the economic life elasticity of transmission lines.
Renewables, Energy Mix and Inflation in the European Union Countries
Authors: Markowski Łukasz , Kotliński Kamil
Published: November 2023

One of the effects of the 2022 energy crisis was a high increase in inflation. According to a review of the literature on the subject, a factor that may increase the economy’s resistance to external price shocks is the relatively high share of renewable sources in energy production. The aim of this paper is to assess the relationship between the share of renewables in energy production and the level of HICP and core inflation in a cross-sectional approach in the crisis year of 2022 within the EU countries. This study used regression methods, cluster analysis and dispersion measures. As a result of the analysis, it was found that in 2022 (using a cross-sectional approach), there was a statistically significant relationship between the above-mentioned variables. A higher share of renewables by 1 p.p. meant lower HICP by 0.13 p.p. and lower core inflation by 0.1 p.p. “Wind” and “solar” had the greatest importance in the multiple regression equation. It can also be stated that in 2022, countries with a similar energy mix structure were characterized as having a similar rate of inflation. It is therefore justified to increase the share of renewables in energy production, because it brings not only positive environmental but also economic effects.