bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Brand Strategy Roadmap (Studi Kasus Starbucks Coffee)
Authors: Rahmadianto Sultan Arif
Published: January 2023

Pada zaman sekarang, persaingan bisnis tidak lagi mengacu pada masalah kualitas produk melainkan pada masalah brand. Brand yang bagus akan meningkatkan kualitas produk dimata konsumen dengan sendirinya. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis brand strategy dalam brand “Starbucks” dengan menggunakan pendekatan brand roadmap. Dari analisis yang telah dilakukan berdasarkan kontekstual internal (nilai inti) dan eksternal (pesan inti, kepribadian, dan ikon). Brand Starbucks Coffee menggambarkan bahwa Starbucks sebagai brand yang sangat konsisten dalam memberikan gambaran pada publik sehingga brand Starbucks konsekuen dan profesional. Manfaat penelitian ini adalah memberikan gambaran tentang bagaimana menyampaikan pengetahuan brand sehingga mudah dikomunikasikan dan dipahami oleh setiap orang baik itu, pegawai, rekan, pelanggan, atau investor yang berinteraksi dengan brand tersebut.
Analisis Ikonologi Iklan Billboard Go-Pay di Yogyakarta
Authors: Wibowo Arif Ardy , Ayu Dinda Destiana Fahma
Published: January 2023

Iklan merupakan salah satu bentuk promosi yang paling dikenal, hal tersebut dikarenakan oleh daya jangkau yang luas. Iklan juga dirasa memiliki kemampuan untuk menarik perhatian masyarakat terutama produk yang iklannya populer untuk dikenal di masyarakat. Billboard merupakan media luar ruang yang paling utama. Billboard adalah sebuah iklan yang disajikan dalam ukuran besar. Ukuran besar ini didesain untuk dilihat orang-orang yang melakukan perjalanan menggunakan kendaraan dengan tujuan memperkenalkan merk. Tujuan dari penelitian ini untuk mengungkap  makna ideologi yang terkandung dalam iklan billboard Go-Pay.

Dalam penelitian ini penulis memakai penelitian deskriptif kualitatif. Adapun subjek utama penelitian dan bahan utama yang akan dikaji dan dianalisa adalah iklan billboard Go-Pay di Yogyakarta, sedangkan objek pada penelitian ini akan difokuskan pada ideologi yang terkandung pada pesan iklan billboard Go-Pay di Yogyakarta dengan menggunakan analisis ikonologi oleh Gillian Dyer. Data diperoleh dari observasi dan dokumentasi.

Berdasarkan analisis yang dilakukan maka dapat disimpulkan bahwa makna ideologi dalam iklan billboard Go-Pay adalah mudah, efisien dan aman. Artinya, Iklan billboard Go-Pay di Yogyakarta menawarkan  hal yang memberikan kemudahan melakukan berbagai pembayaran,  menawarkan efisiensi (mudah dan cepat) dan menjamin keamanan bertransaksi karena seluruh transaksi tercatat dalam sistem dan keamanan karena untuk dapat mengakses Go-Pay pelanggan harus memasukkan kata sandi dan kode OTP melalui nomor yang terdaftar. Dengan demikian, pelanggan tidak perlu merasa takut kehilangan saldo apabila terjadi sesuatu dengan gawai mereka.
Analisis Tanda dan Makna pada Desain Logo Sanggar Tari Puspitasari
Authors: Nurfitri Rina
Published: January 2023

Logo tersebut memiliki nilai estetika sesuai dengan unsur-unsur seni yang terdapat pada desainnya. Keunikan dari logo puspitasari adalah berhubungan dengan ciri khas dari sanggar tersebut. Logo menjadi penentu atau bahkan sebagai simbol keberadaan suatu tempat pelatihan. Logo yang digunakan pada Puspitasari terdiri dari logotype dan logogram. Hal ini terlihat pada  penggunaan teknik lettering yang dikombinasikan dengan elemen gambar. Logo Pupitasari didominasikan oleh tulisan karena mengandung kata, huruf,  slogan. Dari klasifikasi bentuk yang terdapat pada logo, dai segi konstruksinya Puspitasari termasuk pada picture mark sekaligus lettermark. Tanda tersebut saling melengkapi dengan kombinasi penggunaan logogram dan logotype sudah dapat dikatakan mewakili dari identitas sanggar tari Puspitasari. Ciri khas yang ditampilkanpada logo tersebut mewakili dari bentuk tubuh sang penari dan lambing kelopak bunga mewakili dari nama sanggar tari tersebut yaitu sanggar tari Puspitasari.
Re-Branding dan Perancangan Promosi untuk Clothing Maker-Garmen di Malang
Authors: Ignacia Callista , Setiyati Etsa Astridya , Sukmaraga Ayyub Anshari
Published: January 2023

Dalam mendirikan sebuah usaha, nama merek dan kualitas produk menjadi hal penting yang perlu diperhatikan. Oleh karena itu, dengan adanya branding atau re-branding dapat menjadi batasan dan pembeda setiap pelaku usaha satu dan usaha lainnya. Selain itu, perancangan media promosi juga sangat membantu dalam meningkatkan awareness. Objek perancangan dalam Tugas Akhir ini adalah Clothing Maker-Garmen di Malang. Clothing Maker-Garmen merupakan salah satu usaha kecil menengah yang bergerak di bidang konveksi baju. Sejak didirikan pada tahun 2014, Clothing Maker-Garmen belum banyak dikenal masyarakat luas. Oleh karena itu, perlu dilakukan re-branding guna meningkatkan brand awareness serta pendapatan usaha (income). Media yang dihasilkan berupa logo (positif dan negatif), slogan, corporate identity (kop surat, amplop, stempel, nota pembayaran), buku graphic standart manual (GSM), serta media promosi berupa brosur, kartu nama, buku katalog dan merchandise. Metode yang digunakan yaitu metode kualitatif-deskriptif. Teknik pengambilan data yang dilakukan adalah melalui proses wawancara (in depth interview) serta studi literatur. Analisis data yang digunakan pada re-branding dan perancangan promosi adalah analisis Segmentation, Targeting dan Positioning (STP). Perancangan yang digunakan berupa perancangan media dan perancangan kreatif. Hasil dari perancangan re-branding yang didapat berupa peningkatan brand awareness yang berdampak pada peningkatan jumlah konsumen serta pendapatan usaha (income).
Perancangan Media Promosi Sebagai Upaya Pengenalan Toko Kopi Sido Mukti Malang
Authors: Jonathan Jonathan , Rahmadianto Sultan Arif , Sukmaraga Ayyub Anshari
Published: January 2023

Industri 4.0 ditandai meningkatnya penggunaan teknologi informasi. Toko yang berdiri sejak 1950 ini belum memanfaatkan teknologi informasi dalam promosinya. Tugas akhir ini bertujuan merancang media promosi dengan media sosial Instagram karena pertumbuhan penggunanya tinggi dan media cetak. Penggunaan Instagram dan media cetak bertujuan mempromosikan Toko Sido Mukti untuk dapat bersaing di era industri 4.0. Metode kualitatif digunakan untuk mendeskripsikan suatu obyek. Teknik perancangan diawali dengan pengambilan data melalui observasi, wawancara, dan dokumentasi. Dari observasi didapatkam data keadaan toko dan lingkungannya. Dari wawancara didapatkan sejarah toko, perkembangan toko, dan keunggulan produk. Data tersebut didokumentasikan dengan rekaman suara, foto, serta video. Tema desain yang digunakan adalah vintage serta ilustrasi cross-hatching. Keluaran akhirnya berupa desain Instagram dan media cetak pendukung lainnya. Kesimpulannya adalah segala jenis usaha sebaiknya mengikuti perkembangan yang ada agar mampu bersaing tanpa meninggalkan keunggulan yang telah ditawarkan. Perancang selanjutnya diharapkan agar mampu mengeksplorasi keunggulan Toko Sido Mukti yang belum dimunculkan.
Perancangan Motion Graphic Bangga Kecantikan Lokal (Indonesia) Kepada Remaja Putri Usia 18-22 Tahun di Indonesia
Authors: Adiningsih Prastiti Setya , Prasetia Bintang Pramudya Putra
Published: January 2023

Kecantikan adalah salah satu faktor penting yang mempengaruhi kehidupan seorang perempuan. Di Indonesia, lebih dari 90% perempuan mengatakan bahwa kecantikan memiliki pengaruh pada kehidupan mereka, seperti kehidupan sosial, pekerjaan, popularitas, dan juga kesempatan dalam mendapatkan pasangan. Standar kecantikan selalu mengalami perubahan mengikuti perkembangan jaman, tidak terkecuali standar kecantikan di Indonesia. Oleh sebab itu dibuatlah sebuah perancangan video motion graphic yang dapat mengedukasi masyarakat, khususnya perempuan Indonesia untuk memahami lebih dalam tentang kecantikan dan senantiasa ikut serta dalam mempertahankan kecantikan Indonesia.
PENDAMPINGAN BELAJAR KELOMPOK BERBANTUAN FUN PUZZLE
Authors: Patricia Firda Alfiana , Zamzam Kenys Fadhilah
Published: January 2023

The learning process carried out at each individual's home experienced many obstacles during its implementation, including students easily bored, students' interest in learning decreased, and the learning process carried out was less focused so that the learning process was less effective. The learning process individually experiences obstacles because parents pay less attention to their children's learning process for reasons of being busy working, besides that it is also caused by a lack of knowledge. One solution to overcome this problem is through learning assistance activities which are part of the form of community service. Learning assistance through tutoring activities can improve achievement as well as learning motivation. The implementation of learning assistance with the group work method consists of five stages including: preparation, assessment, planning, intervention, and termination. The existence of this learning assistance activity helps students' ways of thinking become more open so that apart from influencing academics, they also learn how to socialize. This is evidenced by changes in attitude before the activity is carried out and after the activity is carried out.
The Relationship Between Cervical Cancer Severity and miRNA-205 Expression in Bali
Authors: Sari Kartika , Lestari Desak Putu Oki , Novitasari Novitasari , Nugraha Yudhi , Prasasty Vivitri Dewi , Sakti Septi Panca
Published: January 2023

Cervical cancer is the one of leading cause of death for women worldwide. It occurs due to infection with the human papilloma virus (HPV) which attacks the cervix in the female reproductive organs. The detecting cervical cancer method is by using pap smears and liquid based cytology (LBC) and vaccinations. However, both methods are limited in detecting cervical cancer quickly and accurately. This study aims to find potential biomarkers that will be used to quickly detect the development of cervical cancer. Large-scale studies have shown that microRNA-205 (miRNA) regulation has a very important role in various types of cancer including cervical cancer. The extraction and synthesis of cDNA from 26 preparations of cervical cancer paraffin blocks were measured by quantitative real time PCR to evaluate the expression of miRNA-205 as a biomarker of cervical cancer in cervical cancer samples. Statistical results showed that there was a significant difference in the expression of miRNA-205 which was relatively higher in cervical cancer patients (p<0.05) miRNA-205. In addition, the increased expression of miRNA-205 is associated with an increase in the severity of cervical cancer. We conclude that miRNA-205 is a potential candidate for cervical cancer molecular biomarker.
Capacity to Consent of People with Dementia: a Narrative Review from an Ethical Perspective
Authors: Hisan Urfa Khairatun , Qomariyah Nurul , Elizabeth Kristina
Published: January 2023

People with dementia have impairment to execute daily life activities by presenting as a deterioration of mental processes, such as memory, thinking, reasoning, and judgment. Many participants in dementia research may lack the capacity to provide informed consent. Additional safeguards are needed for dementia research participants’ protection because of their vulnerability. Only after carefully weighing the risks and possible benefits for the participants in the research may it be decided to use vulnerable participants. The intention to prevent harm pushes against the removal of autonomy. This dilemma is the driving force behind this article's narrative review of the capacity to consent problems in dementia research. For this critical narrative review, we conducted a thorough search of Scopus, PubMed, and Wiley Open Library for literature addressing the ethical and legal issues on the capacity to consent of people with dementia. We outline the dilemmas and difficulties that surround them including the related ethical principles, the informed consent process, capacity to consent, and safeguards for the participant in research involving people with dementia.
Risk of Back Pain in Faculty of Medicine UPN Veteran Jakarta Students During Online Lectures in the 2020 COVID-19 Pandemic Era
Authors: Saputra Dwi Arwandi Yogi , Saputra Hermawan , Sutoto Sutoto
Published: January 2023

Online learning is learning that is done without face-to-face but through available platforms. All forms of learning materials are distributed online. Communication is done online and tests are also conducted online. During the Covid-19 pandemic, distance learning using devices such as laptops and smartphones is very much needed to support distance learning activities. This has an impact on increasing the risks that arise such as back pain.
Retrospective Analysis of COVID-19 Vaccination in a University Hospital and the Relationship with the Epidemic Rate
Authors: Alıravcı Işıl Deniz , Gümüşer Fatma , Şener Alper
Published: January 2023

It was aimed to make a retrospective analysis of the vaccines administered in the vaccine unit of our hospital since the beginning of the COVID-19 pandemic. The study was carried out retrospectively from the vaccination records our hospital, 14 January 2021 to 01 July 2022. In the 18-month period, a total of 75079 (100%) vaccines were administered, 59386 (79%) were Biontech and 15693 (21%) were Sinovac vaccines. Only Sinovac was available until June, therefore, 66% of the Sinovac vaccines were administered in the first five months period. After the Biontech vaccine started to be applied in our hospital, the rates of Sinovac vaccination have declined drastically.  When the epidemic and vaccination graphs were examined separately, inverse correlation was found between the peak points of the epidemic and vaccine graphics. Biontech was found to be the most preferred vaccine by individuals against COVID-19 in this study.
Critically Ill Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Developing Sepsis and Potassium Disorder: a Case Report in Secondary Hospital Setting
Authors: Pinastika Regia Anadhia , Rahmawati Indah , Putrianda Tiara Nadya
Published: January 2023

Sepsis and electrolyte disturbances are frequently experienced among acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. It is characterized by organ failure brought on by unbalanced host response to infection. A 63-year-old male presented to the hospital with the complaint of breathlessness with the oxygen saturation of 76%. The leukocyte level increased to 19.000 and the Potassium level decreased to 2.88. The combination of antibiotics, Potassium supplement, oxygen support through NRM of 15 liters per minute and symptomatic treatment were administered to the patient. The NRM was then changed to HFNC due to his worsening condition and successfully decreased oxygen demand. The patient’s condition has made a significant improvement after seven days of hospitalization. Patients with AECOPD are at higher risk of developing sepsis and electrolyte disturbances. Sepsis will change the biological system of the body due to different pathophysiology such as electrolyte imbalance and obviously engaged with the pathogenesis of ensuing regular intensifications. It is important for the clinicians to know the effective management for the patient, so that the critical phase can be passed even at the limited facilities.
The Effect of High-Intensity Interval Training on Blood Lactate Levels and Rate of Perceived Exertion in Sedentary Healthy Adults
Authors: Damayanti Nur Ahlina , Nusdwinuringtyas Nury , Uliana Tambunan Tresia Fransiska , Kekalih Aria
Published: January 2023

The high-intensity interval training has been seen to be beneficial for various populations. This study aimed to determine the effect of high-intensity interval training (HIIT) on blood lactate levels and rate of perceived exertion (RPE) in sedentary healthy adults. A pre-post study was conducted on adults that were stated healthy and sedentary on physical activity. All participants were given HIIT with a total duration of 20 minutes for 12 sessions using a treadmill. Blood lactate level and RPE was recorded on the 1st and 12th session. A significant decrease in blood lactate level and RPE after giving HIIT was found with a reduction of 1,1 mmol/ L and 2 on the Borg Scale respectively (p<0.0001). Further research is needed using field-based exercise testing to determine exercise prescription and to obtain the benefit of HIIT in populations with cardiovascular risk factors before utilizing it in patients.
Environmental DNA metabarcoding reveals seasonal and spatial variation in the vertebrate fauna of Ilulissat Icefjord, Greenland
Authors: Schiøtt S , Jensen MR , Sigsgaard EE , Møller PR , Avila MdP , Thomsen PF , Rysgaard S
Published: January 2023

Ilulissat Icefjord in Greenland is experiencing the effects of climate change, with the Sermeq Kujalleq glacier being one of the fastest-moving and most productive ice streams in Greenland. This is likely affecting the distribution of species in the fjord, including those important to local fisheries. Due to heavy ice conditions, few studies on environmental and ecological conditions exist from the fjord. However, new techniques such as environmental DNA (eDNA) metabarcoding now allow deeper insight into the fjord system. Here, we combine local ecological knowledge with data on hydrographic conditions, stable isotopes (δ18O), and eDNA metabarcoding to investigate the spatial and seasonal distribution of marine fish and mammals inside Ilulissat Icefjord. Our eDNA results support local observations that Arctic char migrate to the southern fjord during summer, harp seals forage in large herds in the fjord system, polar cod is the dominant prey fish in the area, and Greenland shark likely does not reside in the fjord system. Lower predation pressure in the Icefjord, due to the absence of Greenland shark and polar bears as well as limited fishing/hunting, is presumably one of the reasons why ringed seals and Greenland halibut are larger in the Icefjord. Furthermore, our results indicate that in summer, the southern branch of the fjord system has a more diverse community of vertebrates and different water masses than the northern branch and main fjord, indicating a time lag between inflows to the different branches of the fjord system. Our approach highlights the value of combining local ecological knowledge with scientific research and represents a potential starting point for monitoring biological responses in Ilulissat Icefjord associated with climate-induced changes.
Characteristics of ringed seal Pusa hispida (‘natchiq’) denning habitat in Kotzebue Sound, Alaska, during a year of limited sea ice and snow
Authors: Lindsay JM , Hauser DDW , Mahoney AR , Laidre KL , Goodwin J , Harris C , Schaeffer RJ , Schaeffer R , Whiting AV , Boveng PL , Laxague NJM , Betcher S , Subramaniam A , Witte CR , Zappa CJ
Published: January 2023

Sea ice and snow are essential to Arctic ecosystems, playing key roles in the lives of Arctic marine mammals and the Indigenous Peoples who rely on them. Ringed seals Pusa hispida (‘natchiq’ in Iñupiaq) use snow-covered dens on sea ice for pupping, but quantitative information on denning habitat requirements is limited, and it is unknown how changes in snow depth and sea-ice extent will impact ringed seals. Here, an Indigenous Elder Advisory Council and a multidisciplinary group of scientists used knowledge co-production to quantify fine-scale ringed seal habitat selection patterns in Kotzebue Sound, Alaska (USA), during a year of unprecedentedly limited snow and sea-ice availability. Together, we conducted unoccupied aerial vehicle-based surveys during spring 2019 and related seal counts to survey date, bathymetry, and novel proxies for snow depth and surface roughness that we derived from Landsat 8 surface reflectance and validated with on-ice measurements. Generalized additive models showed that counts of seal groups (all age classes) and pups were associated with later survey dates, deeper water, and habitat with bright Landsat 8 pixel values and intermediate pixel variability, which in turn were correlated with deep snow and surface roughness. We observed shallow snow depths, early sea-ice breakup, and high seal densities consistent with the extreme lack of ice available in 2019. Indigenous Knowledge, intentionally woven with scientific data, provided novel and more nuanced understandings of snow and sea-ice conditions for seals. Our results may give a glimpse at future ringed seal habitat and selection in a warming Arctic.
Impact of Aging on Mitochondrial Respiration in Various Organs
Authors: JEDLIČKA J , TŮMA Z , RAZAK K , KUNC R , KALA A , PROSKAUER PEÑA S , LERCHNER T , JEŽEK K , KUNCOVÁ J
Published: January 2023

Mitochondria are considered central regulator of the aging process; however, majority of studies dealing with the impact of age on mitochondrial oxygen consumption focused on skeletal muscle concluding (although not uniformly) a general declining trend with advancing age. In addition, gender related differences in mitochondrial respiration have not been satisfactorily described yet. The aim of the present study was to evaluate mitochondrial oxygen consumption in various organs of aging male and female Fischer 344 rats at the ages of 6, 12 and 24 months. Mitochondrial respiration of homogenized (skeletal muscle, left and right heart ventricle, hippocampus, cerebellum, kidney cortex), gently mechanically permeabilized (liver) tissue or intact cells (platelets) was determined using high-resolution respirometry (oxygraphs O2k, Oroboros, Austria). The pattern of age-related changes differed in each tissue: in the skeletal muscle and kidney cortex of both sexes and in female heart, parameters of mitochondrial respiration significantly declined with age. Resting respiration of intact platelets displayed an increasing trend and it did not correlate with skeletal muscle respiratory states. In the heart of male rats and brain tissues of both sexes, respiratory states remained relatively stable over analyzed age categories with few exceptions of lower mitochondrial oxygen consumption at the age of 24 months. In the liver, OXPHOS capacity was higher in females than in males with either no difference between the ages of 6 and 24 months or even significant increase at the age of 24 months in the male rats. In conclusion, the results of our study indicate that the concept of general pattern of age-dependent decline in mitochondrial oxygen consumption across different organs and tissues could be misleading. Also, the statement of higher mitochondrial respiration in females seems to be conflicting, since the gender-related differences may vary with the tissue studied, combination of substrates used and might be better detectable at younger ages than in old animals.
Academy™: An Online Diabetes Educational Programme for Healthcare Professionals
Authors: Taylor Jennifer
Published: January 2023

The last decade has seen a rapid expansion in the use of technology by people living with Type 1 diabetes. But how should the information generated by this technology be interpreted and used to inform patient management?This is where Academy™ comes in, providing free certified education on best practice for using the plethora of options in diabetes technology.

In this interview with EMJ, Pratik Choudhary, Professor of Diabetes, Leicester Diabetes Centre, University of Leicester, UK, and Chair of the Diabetes Technology Network-UK (DTN-UK), outlined the genesis and development of the Academy online platform, what it currently offers, and what is in the pipeline for this unique resource.
Can Human Milk Oligosaccharides Modulate the Allergic Response and Improve the Management of Cow’s Milk Protein Allergy?
Authors: Boreham Helen
Published: January 2023

During this symposium, leading experts in paediatric allergy and immunology reviewed new evidence for the role of human milk oligosaccharides (HMO) in supporting the development of the infant microbiota and modulating the immune system, thereby improving the clinical management of cow’s milk protein allergy (CMPA). Liam O’Mahony, University College Cork, Ireland, explored the mechanisms by which HMOs can modify the gut microbiome and beneficially influence allergic and infectious responses in both healthy infants and those with CMPA. New data from the CINNAMON study were showcased by Claire Boulangé, Nestlé Institute of Health Sciences, Lausanne, Switzerland, highlighting key mechanisms by which specific HMOs can support the microbiome and modulate metabolome production that may lead to important immune benefits in CMPA. Finally, Anna Nowak-Węgrzyn, Professor of Pediatrics and Chief of the Division of Pediatric Allergy and Immunology at the Grossman School of Medicine, New York University (NYU) Langone Health, USA, presented results from the Platypus study, in which infants with moderate-to-severe CMPA were fed an amino acid (AA)-based formula containing two HMOs. Symptoms of CMPA decreased significantly in infants fed the HMO-supplemented formula, and these clinical improvements were accompanied by normal growth and positive changes to the faecal microbiome. Collectively, these findings translate to important immune benefits and a key role for HMO-supplemented formula in the clinical management of CMPA.
Mortality in Patients with Pad with Respect to Glycaemic Status: A Review
Authors: Hjellestad Iren D. , Jonung Torbjørn
Published: January 2023

Peripheral arterial disease (PAD) is a manifestation of atherosclerosis. Atherosclerosis is a chronic inflammatory process and nonenzymatic glycation is a process of major interest in relation to how risk factors promote atherogenesis. A strong association between diabetes mellitus (DM) and PAD has been established, and the association is related to the duration of DM. Previous studies have revealed a higher prevalence of DM in patients with PAD compared to general populations and populations at risk of developing DM. The typical dyslipidaemia found in patients with PAD is similar to that found in patients with insulin resistance, and an association of HbA1c with atherogenic dyslipidaemia is described. HbA1c has been described as a predictor for DM and of micro and macrovascular disease. 5-year all-cause mortality in PAD is 19–37% and 10-year all-cause mortality is 42-54%. The mortality in PAD increases with age, with the severity of the peripheral vascular disease, and with the coexistence of PAD with coronary artery disease and DM. Patients with DM, defined by glucose criteria, and PAD have an increased mortality compared with patients with PAD alone. Recent studies have shown an association of HbA1c levels with vascular complications and death in patients with DM. No studies could be found that aimed to validate HbA1c against glucose criteria as a predictor for mortality in patients with PAD. Further studies on patients with PAD and DM are needed to identify which is the best diagnostic method to predict mortality in PAD with respect to glycaemic status: the glucose parameters or the HbA1c.
The Role of Environmental Factors in Digestive Cancer
Authors: Lambert Rene
Published: January 2023

The risk of digestive cancer in each country is analyzed in cancer registries for Incidence and Mortality. Survival is estimated from registries with a correct follow-up. Estimated values of Incidence and Mortality, expressed as an age standardized rate (ASR) for 100 000 persons, for all the population of a country are also found in the WHO-IARC database Globocan, recently edited for the year 2008. At each site of digestive tumors, the variations between countries, in cancer incidence, mortality and survival, depend on the resources and the global health status of the country. Indeed environmental causal factors linked to lifestyle may have an increasing or decreasing impact on the risk of cancer. Such factors are classified on 3 categories: 1- nutrition plays a determinant role in colorectal cancer with a higher risk in countries with more resources and more calories in the diet. 2- Toxic agents like alcohol and tobacco increase the risk at all sites of digestive cancer; their role is preponderant in esophageal cancer. Aflatoxin, a food contaminant in tropical, less developed countries, increases the risk of liver cancer. 3 – Infectious agents play a major role with the Bacteria H.pylori for stomach cancer over the world, and the Hepatitis virus B and C for liver cancer in less developed countries of Africa and Asia. The control of carcinogenic causal environmental factors is included in the primary prevention of digestive cancer.
The Versatile Role of the Vagus Nerve in the Gastrointestinal Tract
Authors: Stakenborg Nathalie , Di Giovangiulio Martina , Boeckxstaens Guy E. , Matteoli Gianluca
Published: January 2023

The vagus nerve, the major nerve of the parasympathetic nervous system, innervates several organs from the neck to the abdomen. The vagal branches contain afferent (i.e. sensory) and efferent (i.e. motor) fibres contributing to a bidirectional communication between the visceral organs and the brain. The extensive vagal innervation of the body indicates that vagus nerve has a multitude of physiological functions. Specifically, the gastrointestinal (GI) tract is densely innervated by the vagus nerve and the latter plays a crucial role in GI functions such as food intake, digestion, and GI barrier function. In addition, the vagus nerve has immunomodulatory properties suggesting that activation of the parasympathetic innervation of the GI tract could act as a new therapeutic tool to treat intestinal immune diseases. This review summarises the anatomical and physiological properties of the vagal innervation of the GI tract.
Looking Back To Our Roots: 80 Years of Wintrobe’s Indices
Authors: Urrechaga Eloísa , Izquierdo Silvia , Escanero Jesús F.
Published: January 2023

This year (2014) we are celebrating the 80th anniversary of Dr Maxwell Myer Wintrobe’s pioneer works, one of the most important contributions in clinical laboratory and medicine. Red cell indices continue to provide an essential support to the diagnosis and classification of anaemia. The erythrocyte indices, such as mean cell volume, mean cell hemoglobin concentration, and mean cell hemoglobin, are called the Wintrobe’s indices. Automation in hematology has progressed steadily since Wallace Coulter first applied electrical impedance technology to counting red cells and white cells. Technological advances being incorporated into hematology analysers since then are now allowing access to more cellular information than was ever available before through a ‘simple routine complete blood count’. Current research is beginning to demonstrate that this information also has great potential to identify cellular changes that typically occur in several important medical conditions-bringing us all one step closer to using hematology analysers as more than just simple cell counters, but instead as powerful tools for the management of any medical condition that impacts the biology of blood cells. There are increasing amounts of data provided, which require specialist knowledge to interpret as well as to understand the limitations in the measurement of the parameter. Both laboratory scientists and clinicians need to keep up-to-date with new parameters and methods in hematology, implying a stronger collaboration between them to improve clinical decision-making.
Adrenal Insufficiency (AI) in Cirrhosis
Authors: O’Brien Julia , Fede Giuseppe , Burroughs Andrew K
Published: January 2023

10.33590/emjhepatol/10310451
Autosomal Dominant Polycystic Kidney Disease: What Do We Need To Know For Counselling?
Authors: Piccoli Giorgina Barbara , Pia Anna , Neve Vigotti Federica , Guzzo Gabriella , Clari Roberta , Attini Rossella , De Pascale Agostino , Solitro Federica , Arena Vincenzo , Veltri Andrea
Published: January 2023

In the new millennium, few kidney diseases changed their perspectives as much as autosomal dominant polycystic kidney disease (ADPKD). New diagnostic approaches, including the evaluation of renal or liver volume by computerised tomography (CT) scan, the detection of cyst infections by positron emission tomography (PET) scan, and new therapeutic approaches (including vaptans, mTOR inhibitors, and somatostatin analogues) pose new clinical and ethical dilemmas. Therefore, the analysis of the recent advances offers an occasion for reviewing our counselling policy. The aim of this narrative review is to discuss a few crucial points concerning counselling in ADPKD: should all ADPKD patients undergo genetic testing for characterisation of the involved gene? What is the role of prenatal counselling and preimplantation selection? Should all ADPKD patients be followed in a nephrology clinic? Which imaging to use in which patients? Whom should we treat, when, and by which drugs, and how to communicate the treatment options? The working conclusions highlight the trends towards earlier referral of ADPKD patients, the importance of offering the diet options, including low-salt, high-water intake, difficult to follow, but devoid of side-effects, and the expectancy for the new therapeutic options, alone or in combination, aimed at reduction of cyst volume and/or control of cyst growth.
Scientific approaches to the use of self-seeded forests on agricultural lands of private property in territorial communities
Authors: Dorosh O. , Zastulka I.-O.
Published: January 2023

Based on the given data on the level of forest cover in the regions of Ukraine, it was found that forests grow unevenly and, accordingly, this indicator varies from 3.7% in Zaporizhzhia to 51.4% in Zakarpattia Oblasts. It is substantiated that this problem can be overcome through the legal protection of self-seeded forests on privately owned agricultural lands. It was found that most of the problems, shortcomings and gaps in the legislative, economic and political direction related to the use of these lands are settled by the Law of Ukraine “On Amendments to Certain Legislative Acts of Ukraine on the Preservation of Forests” No. 2321-IX dated June 20, 2022. The concept of self-forested land has been clarified and it has been established that a plot of land is considered to be self-forested, provided that information about the belonging of all its lands to self-forested land is entered in the State Land Cadastre. Studies conducted on the further fate of self-seeded forests within the territories of territorial communities indicate that the preservation of self-forested lands on agricultural lands and natural meadow lands is not always expedient and economically justified in terms of territorial communities in different regions of Ukraine due to their inherent specificities. The facts of the presence of self-forested land plots on the territory of the investigated territorial communities have been established. Accordingly, scientific approaches to their solution are proposed. In particular, it is suggested that with a significant dominance of forest lands in the structure of the community’s land fund, namely, in the case of more than 50% forest cover and the predominance of forest land areas in more than two times over agricultural lands, self-afforestation of agricultural lands on the territory of the community should not be allowed.
Theoretical basics of the efficiency of the functioning of local government bodies
Authors: Malinovska O. , Revutskyi A.
Published: January 2023

The work has been devoted to the study of the theoretical foundations of the effectiveness of local self-government bodies. The main approaches to the interpretation of scientific categories: “efficiency of public administration”, “target efficiency” and “economic efficiency” have been analyzed. The main indicators of the effectiveness of the structural divisions of local self-government bodies have been studied: the number of administrative documents adopted by the public administration body, the number of events carried out or participation in them in accordance with the approved administrative documents, the indicator of the amount of humanitarian aid received by the community. Also the existing scientific concepts and approaches used to evaluate management effectiveness have been considered. These include target concept, system concept, balance of interests concept, functional concept, compositional concept.
Music as an enhacer of EFL spelling skills in diverse secondary classrooms
Authors: García-Carmona Sofía , Fernández-Corbacho Analí
Published: January 2023

This research has as a main aim to check the benefits of using music in the FL classrooms, specifically with students who present lower proficiency levels in the target language. In order to carry out this project, the design of a pedagogical intervention has been necessary. In particular, two groups of the first year of secondary education took part. One group belonged to a bilingual program, the other one was a group formed by students with some difficulties in their learning process, due to diverse circumstances. The intervention focused on teaching the spelling of the sounds /aI/, /eI/, /i:/ and of regular and irregular verbs in the past simple tense having music an essential role during the sessions. The intervention lasted three sessions, data was collected through two dictation passages made at the beginning and at the end of the intervention. Classroom observation also offered qualitative data. Data gathered show interesting results which are highly positive. However, some students would need more time to acquire the knowledge expected. Finally, some pedagogical implications for future teaching interventions are provided.
Суспільно-політична діяльність поляків Уманського повіту початку ХХ ст. у висвітленні газети «Киевлянин»
Authors: Kuznets Tetiana
Published: January 2023

Метою статті є аналіз виявлених у губернській газеті «Киевлянин» публікацій про суспільно-політичну діяльність поляків Уманського повіту початку ХХ ст. Це сприятиме кращому розумінню глибинної сутності польсько-російського антагонізму, який посилювала імперська влада для зменшення польських політичних впливів.

Наукова новизна роботи полягає у тому, що увиразнено оцінку консервативною (у досліджуваних хронологічних межах) губернською газетою «Киевлянин» російської імперської політики щодо суспільно-політичної активності поляків у роки виборів до Державної думи та формування виборних земств. З’ясовано, що на шпальтах газети акцентувалась увага на прагненні імперської влади обмежити участь поляків у політичному процесі, залишивши їм єдине поприще вияву активності – діяльність у місцевих земствах.

Висновки. З’ясовано, що губернська газета «Киевлянин», яка виходила великим накладом і поширювалась по усьому Південно-Західному краєві, публікувала матеріали про російсько-польський антагонізм на інкорпорованих українських територіях. Публікації про суспільно-політичну діяльність поляків на початку ХХ ст. у межах одного повіту дали підстави зробити висновок, що русифікаторська політика імперії була спрямована на зменшення польських політичних впливів. Сприятливим часом для розвитку активності поляків були роки виборів до Державної думи – першого представницького органу влади в Російській імперії та формування виборних органів місцевого самоврядування – земств. Опубліковані у 1906-1912 рр. на шпальтах «Киевлянина» матеріали про участь поляків повіту у цих процесах доповнюють знання про сутність політики деполонізації. Участь поляків у суспільно-політичному житті регулювалася такими важелями як заборона укладання угод під час виборів до Державної думи та запровадження польської та російської курії під час формування виборних земств. Російська влада для активної діяльності поляків залишала тільки участь у місцевих земствах. Риторика газетних публікацій з цього приводу вказує на співчутливу оцінку консервативним «Киевлянином» можливостей участі поляків у суспільно-політичному житті на українських землях початку ХХ ст.
Стратегії виживання єврейського духовенства в радянській Україні в 1920–1930-х роках
Authors: Savchuk Tetiana , Ihnatusha Olexandr
Published: January 2023

Мета дослідження – визначити зміст і зміни стратегій виживання юдейського духовенства в радянській Україні в умовах суспільних трансформацій 1920–30-х рр.

Методологія дослідження включає поєднання макро- та мікроісторичних підходів для реконструкції повсякдення єврейського духовенства. Застосовано біографічний метод для показу життєвих траєкторій окремих представників юдейського духовенства та з’ясування впливу суспільно-політичних подій на формування їх соціальної поведінки.

Наукова новизна полягає в історичній реконструкції стратегій виживання юдейського духовенства в Україні протягом 1920-30-х рр. Показано залежність зміни цих стратегій від форм і способів тиску державно-політичної влади та сили етноконфесійних традицій у середовищі єврейської спільноти.

Висновки. На формування стратегій виживання юдейського духовенства в Україні протягом 1920-30-х рр. впливало посилення й урізноманітнення суспільно-політичних викликів, що були результатом зміцнення тоталітарної системи. Особливо відчутними в середовищі юдейського духовенства були зміни соціальної та національної політики у формі голодоморів, пониження соціальних стандартів, посилення антирелігійного тиску, політичних репресій. У 1920-х рр. умови суспільно-політичного життя були ще відносно сприятливими для малочисельного єврейського духовенства. Затребуваність релігійних послуг, авторитет рабинів і канторів у громадах були факторами підтримки соціального становища служителів.

Основними стратегіями виживання юдейського духовенства визначено: слідування етнокультурним традиціям всупереч наростаючому політичному тиску, пошук додаткових господарських занять, отримання допомоги від громади та родини. Культ родини в єврейському соціумі обумовлював тісні взаємозв’язки її членів, що мінімізувало психологічний та економічний тиск атеїзованого суспільства.

Форсування політичного наступу влади на єврейську спільноту на межі 1920-30-х рр. формувало нові стратегії фізичного самозбереження. Юдейське духовенство вимушено відмовлялося від релігійної діяльності, інтенсивно шукало допомоги за кордоном, однак державне адміністрування та репресії комуністичної влади, руйнація нею етноконфесійної інфраструктури стали чинниками обмеження зв’язку євреїв України із закордоном, а відтак – і обсягів їх зовнішньої економічної підтримки. Одним із основних шляхів виходу юдейського духовенства з політичного безправ’я стала еміграція, на яку наважувалися, передусім, члени родин юдейського духовенства. У 1930-х рр. влада заблокувала цей гуманітарний коридор, формуючи тоталітарне суспільство в котлі сталінської модернізації.
Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite
Authors: Li Shaoping , Xiaowen Yundeng , Yang Yuqing , Liu Libo , Sun Yifan , Liu Ying , Yin Lulu , Chen Zhiyu
Published: January 2023

Although tissue engineering offered new approaches to repair bone defects, it remains a great challenge to create a bone-friendly microenvironment and rebuild bone tissue rapidly by a scaffold with a bionic structure. In this study, a multifunctional structurally optimized hydrogel scaffold was designed by integrating polyvinyl alcohol (PVA), gelatin (Gel), and sodium alginate (SA) with aspirin (ASA) and nano-hydroxyapatite (nHAP). The fabrication procedure is through a dual-crosslinking process. The chemical constitution, crystal structure, microstructure, porosity, mechanical strength, swelling and degradation property, and drug-release behavior of the hydrogel scaffold were analyzed. Multi-hydrogen bonds, electrostatic interactions, and strong “egg-shell” structure contributed to the multi-network microstructure, bone tissue-matched properties, and desirable drug-release function of the hydrogel scaffold. The excellent performance in improving cell viability, promoting cell osteogenic differentiation, and regulating the inflammatory microenvironment of the prepared hydrogel scaffold was verified using mouse pre-osteoblasts (MC3T3-E1) cells. And the synergistic osteogenic and anti-inflammatory functions of aspirin and nano-hydroxyapatite were also verified. This study provided valuable insights into the design, fabrication, and biological potential of multifunctional bone tissue engineering materials with the premise of constructing a bone-friendly microenvironment.
Mitochondrial calcium cycling in neuronal function and neurodegeneration
Authors: Walters Grant C. , Usachev Yuriy M.
Published: January 2023

Mitochondria are essential for proper cellular function through their critical roles in ATP synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic signaling. In neurons, Ca2+ buffering is particularly important as it helps to shape Ca2+ signals and to regulate numerous Ca2+-dependent functions including neuronal excitability, synaptic transmission, gene expression, and neuronal toxicity. Over the past decade, identification of the mitochondrial Ca2+ uniporter (MCU) and other molecular components of mitochondrial Ca2+ transport has provided insight into the roles that mitochondrial Ca2+ regulation plays in neuronal function in health and disease. In this review, we discuss the many roles of mitochondrial Ca2+ uptake and release mechanisms in normal neuronal function and highlight new insights into the Ca2+-dependent mechanisms that drive mitochondrial dysfunction in neurologic diseases including epilepsy, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. We also consider how targeting Ca2+ uptake and release mechanisms could facilitate the development of novel therapeutic strategies for neurological diseases.
Multiple Recognition-Based Sensor for Pesticide Residues
Authors: Li Jie , Chen Keren , Zhu Longjiao , Li Xiangyang , Li Changmo , Chang Qiaoying , Xu Wentao
Published: January 2023

The use of pesticides is gradually increasing to improve the yield and quality of crops. However, excessive pesticide use has led to a dramatic pollution increase in the environment and agricultural products, posing severe human health risks. Therefore, rapid, sensitive pesticide detection is essential. Various pesticides detection methods and products have been developed in recent years. This brief review summarized the point-of-care testing (POCT) detection of pesticides based on multiple recognition, including protein-, aptamer-, nanomaterial-, and macrocycle-based recognition. The review aimed to address the growing demands for regulating and destroying pesticides or other adverse agriculture-related applications in the real world.
Cyclodextrin-Based Nanosponges: Overview and Opportunities
Authors: Utzeri Gianluca , Matias Pedro M. C. , Murtinho Dina , Valente Artur J. M.
Published: January 2023

Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.
Ionization of HCCI Neutral and Cations by Strong Laser Fields Simulated With Time Dependent Configuration Interaction
Authors: Schlegel H. Bernhard , Hoerner Paul , Li Wen
Published: January 2023

Graphical Abstract

Time-dependent configuration interaction simulations of the electron dynamics in coherent superpositions of the X and A cation states of HCCI show marked differences in the strong field ionization rates by intense, 2 cycle probe pulses that depend on the initial phase of the superposition and on the carrier envelope phase.