bluuebunny/crossref_metadata_2025 huggingface dataset:
Launchable rotary wing UAV designs and launch mechanism designs for rotary wing UAV
Authors: Gokbel Etka , Ersoy Sezgin
Published: December 2021

In recent years, rotary-wing unmanned aerial vehicles have been used in many areas. Rotary wing unmanned aerial vehicle (UAV) can carry different payloads according to their duties. For example; if they carry cameras, they are used for reconnaissance / surveillance, cargo if they carry cargo, agriculture if they carry pesticides, mapping if they carry an advanced camera and mapping system, and communication if they carry a base station or relay. Rotary-wing unmanned aerial vehicles are usually commanded to take off manually by a trained UAV operator. Before takeoff, the rotary-wing unmanned aerial vehicle is prepared for take-off by the UAV operator and this preparation takes approximately five minutes. It takes time for rotary-wing unmanned aerial vehicles to take off from the runway and reach their cruising speed, causing time loss in critical areas. A rotary-wing unmanned aerial vehicle launch assembly and a rotary-wing unmanned aerial vehicle with an opening mechanism that can open the thrust arms after launch and continue to fly can be the solution to this time loss. Rotary-wing drones capable of launching and without the intervention of the UAV operator will play an important role in emergency response and defense, where situational awareness is often required. For example; firefighters responding to fires can take advantage of the ability to quickly launch rotary-wing unmanned aerial vehicles from a stationary or moving fire truck. Thanks to the day / thermal camera on the launched rotary wing unmanned aerial vehicles, valuable information can be obtained about the progress of the fire and the damage caused by the fire. Thanks to rapid awareness, the fire can be intervened and fought faster. Similarly, military personnel can quickly deploy launchable rotary-wing drones for reconnaissance and surveillance and perform their duties. In order to be applicable to various types of missions, it is important that the rotary wing unmanned aerial vehicle be portable and low in volume. Since the launchable rotary-wing unmanned aerial vehicle proposed in the thesis has an arm release mechanism after launch, it can automatically open and generate thrust after launching its arms. In this way, it helps lower volume coverage before being launched. This also reduces air friction during launch. It can be deployed to autonomous systems effortlessly as it has closed package, mobile and self-arm management. Different mechanisms will be studied to create an efficient design. A mechanism that allows it to open its arms in a short time will be used in the self-arm-opening management design. Throwable rotary wing unmanned aerial vehicle and launch mechanism will be designed and 3D printers will be used for prototype.
Noise pollution contours in metro stations (case study of Tehran metro)
Authors: Forouhid Amir Esmael , Ilkah Mohammad , Mahmoudi Jafar
Published: December 2021

To encourage the society to choose the public transportation system, it should comfort and satisfy people. Noise pollution in urban transportation systems is a risk that can endanger passenger health and affect their use of public transportation. Hence, this study investigates the effect of noise pollution on users’ satisfaction of Tehran Metro line 7 using a sound level meter to measure noise pollution in four stations, namely Sanat Square, Tarbiat Modarres University, Shahid Navvab Safavi, and Rudaki. The data was analyzed using noise measurement, and noise pollution is compared at four stations with noise contour maps.
The stationary response of piezoelectric cantilever beam model excited by colored noise
Authors: Ge Gen , Liu Jie
Published: December 2021

This article provides a method to predict the steady-state response of a piezoelectric cantilever under the excitation of Gaussian colored noise which is a better approximation to the ambient random excitation than the white noise. In this paper, a cantilever energy harvester model, which is fully-paved with piezoelectric ceramic and excited by Gaussian colored noise, is built by the Lagrange’s equations and is nondimensionalized. Then the dynamic equation and piezoelectric equation are transformed into a pair of stochastic differential equations about transient equivalent amplitude and transient phase. After that, the stochastic averaging method is applied to simplify the stochastic differential equations into an Itô type equation about the equivalent amplitude, the drift coefficient and the diffusion coefficient are obtained. This method provides another approach which is different from the stochastic linearization method and moment method. On this basis, some crucial outputs such as the steady-state probability density function (PDF) of the equivalent amplitude, the beam’s displacement, the transient output voltage, the joint probability density function of displacement and velocity as well as the mean square value of output voltage are all obtained. With different noise intensity values and delay factors, the Monte Carlo numerical simulation has verified the correctness of the theoretical prediction.
Cylindrical shell pressure vessel profile variation footprint in strain comparison of test data with numerical analysis
Authors: Pany Chitaranjan
Published: December 2021

The strain comparison of a pressure vessel made of HSLA 15CDV6 in a cylindrical shell membrane region in a pressure test is discussed in this paper. Non-linear finite element analysis (FEA) of thin-walled cylindrical pressure vessels has been carried out using ANSYS. Hoop strain obtained from FEA is not compared well with the pressure test data at the membrane location of the cylindrical shell where the strain gauge is mounted. So to explain the reasons for the difference in strains at the membrane region, the profile of the cylindrical shell at strain gauge region has been measured. The 3D FEA of the cylindrical region with the measured profile is performed. It is found that with measured profile the FEA is giving the strain close to measured strain in the hoop direction. This leads to the increase in strain and stress as having been demonstrated through mathematical modeling in the deviated profiles variations of cylindrical shells. Therefore, the stresses in the deviated region are greater than those that would exist in an undeviated cylindrical shell, which reduces the margin of safety with respect to the yield strength of the material and causes stress concentration. The details of the stress analysis carried out including the effect of measured 3D profile variation are discussed in this paper.
Prefabrik Düşey Drenlerin Farklı Eşleme Yöntemleri ile Sayısal Analizi
Authors: TUNÇ Ufuk , ÇOLAKOĞLU Hüseyin , ÜSTÜNAY Erdem , YILDIZ Abdulazim , BAĞRIAÇIK Baki
Published: December 2021

Yumuşak zeminler üzerine inşa edilen dolgularda zamana bağlı konsolidasyon oturmalarının dikkatli bir şekilde incelenmesi gereklidir. Bu tür zeminlerde konsolidasyon oturmalarını hızlandırmak için kil zemin içerisine prefabrik düşey drenler inşa edilir. Bu çalışma kapsamında, yumuşak zeminler içine inşa edilen düşey dren sistemlerinin farklı eşleme yöntemleri kullanılarak gerçekleştirilen sayısal analizleri araştırılmıştır. Sayısal analizlerin doğruluğu literatürde yer alan büyük ölçekli konsolidometre deney sonuçları ile karşılaştırılarak kontrol edilmiştir. Deney düzeneği, sonlu elemanlar yöntemine dayanan Plaxis 2D bilgisayar programı ile modellenmiştir. Analizlerde farklı eşleme yöntemleri kullanılarak düşey drenler eksenel simetrik koşullardan düzlem şekil değiştirme koşullara dönüştürülmüştür. Modifiye cam kili modeli kullanılarak gerçekleştirilen analizler deneysel ölçüm sonuçları ile karşılaştırılmış ve aralarında oldukça iyi bir uyum olduğu görülmüştür. Bu sonuçlar, düşey dren sistemlerinin 2 boyutlu koşullarda analiz edilebilmesi için geliştirilen eşleme yöntemlerinin doğru sonuç verdiğini ve bu tür mühendislik uygulamaların analizlerinde tasarım mühendislerine önemli kolaylıklar sağlayacağını göstermiştir.
Performance Assessment of ZrO2 Nanofibrous Oxygen Sensor
Authors: ERDEM YILMAZ Özlem
Published: December 2021

An alternative oxygen sensor to conventional ZrO2 based automotive oxygen sensors (COS) was successfully manufactured. ZrO2 nanoparticles were used as base material and nanofibers were fabricated via electrospinning using polyvinyl alcohol and ZrO2 solution (ZrO2+PVOH) to obtain active surface of the sensor where the engine exhaust gas interacts and chemisorption reactions take place prior to calcination process of nanofibers at 700 oC. Thanks to operating temperature control and high surface/volume ratio of nanofibrous structure, the ZrO2+PVOH nanofibrous sensor demonstrated similar performance with COS under increasing exhaust gas percentage (until 50-60%) along with increasing operating temperature conditions. For ZrO2+PVOH nanofibrous sensor, maximum sensing performance (Ra/Re) of 7.24 was achieved at sensor operating temperature of 700 oC and exhaust gas concentration of 50% whereas it was 8.11 for EOS under same conditions. The ZrO2+PVOH nanofibrous sensor performed acceptable performance throughout wider operating temperature range (270-900 oC) compared to conventional COS. Though an average of 15% reduction in sensing performance was observed for ZrO2+PVOH nanofibrous sensor, the promising results of this alternative oxygen sensor will be a good guide for more comprehensive future works focusing on oxygen sensors with very rapid response-recovery time and light-off capability.
Optimization of Urban Cargo Distribution Network and Station Points with Open Source GIS
Authors: BEDİROĞLU Şevket
Published: December 2021

The cargo and transportation sector is growing day by day. Resources need to be managed more efficiently in the face of growth in the sector and fast delivery demand in customer requests. Location selection of cargo branches and route planning processes of cargo vehicles are important in order to manage resources more efficiently. Geographic Information Systems (GIS) provide significant advantages in site selection and route planning processes. Especially open source GIS data and GIS software offer low cost and effective solutions. In this study, the branch locations of a cargo company in ġehitkamil district of Gaziantep province were examined and the routes of the vehicles were analyzed in a way to minimize time loss and fuel consumption. In this context, isochrone maps were produced over the road network. The population numbers within these isochrone zones were calculated and vehicle liability zones were determined according to the population data. Finally, the daily route planning of more than a hundred cargoes, which are required to be delivered by cargo vehicles in one day, has been made.
Application of networked water balance model in refined management of steel industrial park
Authors: Wang Yurong , Li Linyuan , He Wentao , Zhang Xinli , Li Xuanjin , Li Xiang , Li Hongying
Published: December 2021

Water shortages have become a major constraint on China's industrial development. Iron and steel industrial parks have a huge demand for water resources and complex production technologies. Therefore, it is very important to study the distribution, transfer and loss of water resources in industrial parks in order to improve the ability to refine water resources management. The purpose of this study was to reveal the water flow in industrial parks by using the principle of water balance and to provide a method for quantification and characteristic recognition of water resources in industrial production processes. In this research, an iron and steel industrial park in North China was chosen as the case study. In order to calculate the water balance of the whole steel production processes, the industrial park was divided into four levels and 110 water units according to the pipe network system and production processes. Based on the results of multi-level and multi-node water balance, this paper analyzed the water intake structure and water consumption structure of industrial parks, and provided the methods to optimize the allocation of water resources and reduce the consumption of fresh water in industrial production processes. The results of the study showed that the energy department accounted for 60.8% of the total water withdrawal of the industrial park. There were 6,249 m3/day of fresh water in the industrial park, which could be replaced by reclaimed water from urban sewage. Evaporation and pipe network leakage were the main water consumption factors in the steel park, which contributed 91.3% of the water consumption. Under the guidance of the research results, the evaporation water consumption of the industrial park was reduced by 8,412 m3/day, and pipe leakage was reduced by 600 m3/day. This article demonstrates the application of the water balance principle in complex water use systems, which is helpful for water resources management based on water use processes.
Assessing Finance Interaction of Chemical Industry Corporations with State
Authors: Malyshev M. K.
Published: December 2021

The article assessed interaction of state and chemical industry corporations by criteria of budget making, tax burden and managerial impact. The appraisal was made on the basis of methodological tools worked out by the author. Within the period from 2012 to 2020 earnings of corporations of chemical industry producing mineral fertilizers grew and exceeded tax revenues of regions of their location, which caused an increase in companies’ taxation potential. However, analysis of tax payments to the budget system by profit tax, property tax, income tax and VAT did not confirm the growth in this potential. A rise in dividends, payments for losses were typical for enterprises, as well as increasing amount of dividends surpassing net profit. The goal of the article is to identify the level of finance interaction efficiency between state and enterprises of chemical industry. The following enterprises of chemical industry producing mineral fertilizers acted as the object of the research: the public company ‘Apatit’ (Vologda region), the public company ‘Akron’ (Novgorod region) and the public company ‘Dorogobuzh’ (Smolensk region). This choice was stipulated by location of these enterprises in regions with weakly-diversified economic structure and serious dependence on the budget-forming enterprise. The information base of the research was formed by works by Russian and overseas authors dealing with chemical industry development, finance accounting of the companies, data of the Federal Taxation Service and the Treasury of Russia.
Methodology of Writing Literature Review on Management and Business: Digest of Overseas Highly-Cited Articles
Authors: Denisov I. V.
Published: December 2021

The goal of the research is to elaborate methodology how to systematize findings in the field of management published during previous years. Special attention is paid to typology of reviews. In this case the author distinguished systematic (meta-analysis as its variant), semi-systematic, integrative and other types of reviews. The article traces the origin of literature reviews starting from medical science to their use in articles concerning management in business. The author described difficulties of conducting meta-analysis and systematic analysis on materials of research on management and showed several methods of presenting results of systematic review of literature. Review articles can both rely on proofs obtained in previous quality (or mixed) methods of research and include quantitative data. Orientation to author is also possible. The most widely used type is a subject review, where researcher describes publications fostering the development of general comprehension of the concept or phenomenon being of interest, including for the future research. The choice of the review type and methodology of its conducting is determined by the data that should be analyzed. Authors should follow the chosen methodology.
Structural Development of Russian Economy: Assessing the Condition and Prospects of Speeding-Up
Authors: Morozov O. V. , Vasiliev M. A.
Published: December 2021

In the practice of state governance economic development is usually estimated by comparing macro-economic indicators for the period being evaluated with relevant preceding periods. The article studies a non-conventional – structural approach to estimating the development of sectoral structure of Russian economy. The period of 10 years, i. e. from 2011 to 2020 was analyzed, at the same time the possibility of accelerated development in the medium-term (2023) and long-term (2036) periods was investigated. The authors provide theoretical foundations of the research, indicators of structural development, the procedure and algorithms of their estimation. The criterion and quality model of passing-over from the actual condition to the optimal combination of sector scales were identified. By comparing the actual and model (estimated) indicators of sector scales the trend and nature of structural development of national economy were evaluated, as well as its capacity to develop rapidly in future periods. The findings show that harmonization of indicators of diversity and uniformity, changeability and stability in sectoral structure forms a structural precondition for the development of national economy. These indicators can be used by bodies of state governance in the process of devising strategy of accelerated development of economy in general and its industries.
Key Trends in Esg-Agenda Development: Reviewing the Situation in Russia and the World
Authors: Zhukova E. V.
Published: December 2021

The article studies successive implementation of the concept of sustainable development on the international and Russian market starting with the official formulating the concept in the report ‘Our Common Future’, which was presented by the UN in 1987 and till the latest trends of national economy of the Russian Federation. The author provides the gist of key aspects and notions of ESG-approach to management, analyzes their rise and assesses the degree of their academic elaboration and practical use in Russia. On the basis of the current trend analysis a conclusion was drawn about the importance of introducing the concept of management from ESG-standpoint on all levels of economy. Scientific generalization of practical experience allowed the author to come to the conclusion that international trends of sustainable development will determine the general line in ESG-approach to management of social and economic development in Russia on all levels – from federal to corporate one. The article identifies key regulator trends in carbon regulation, the development of tools of green and responsible financing, commitments on ESG-information revealing and risk management. The latest initiatives of big state, public and finance companies in issuance of green bonds were described, as well as acute trends in the state regulator work in ESG- sphere.
Nanoparticles Mediated Target-specific Drug Delivery in Prostate
Cancer: An In-depth Review
Authors: Upadhyay Tarun Kumar , Ali Mohammed Irfan , Khan Fahad , Goel Harsh , Mathur Manas , Goyal Keshav , Moin Sarmad , Pandey Pratibha , Tanwar Pranay , Sharangi Amit Baran , Gautam Saloni Dinesh Chandra , Kapdi Jhanvi Kiran , Patel Kruti Indravadan , Patel Meghna Vipulbhai , Parmar Amisha M. , Kamal Mohammad Amjad
Published: December 2021

:

Nanotechnology has been extensively exploited for its enormous therapeutic
and diagnostic potential in the management of multiple disorders. It employs nanomaterials
as drug carriers with enhanced efficacy and limited side effects on normal tissues. A
lot of nanomaterials have been studied and produced, imminently reforming the treatment
and diagnostics of numerous malignancies, including cancer. The purpose of the
present study is to explore the role of nanotechnology-based devices/therapies that have a
vital function in the therapeutics and diagnostics of cancer with potential impact at three
levels: early detection, tumor imaging, and drug delivery methods. Concentrating on cancer,
promising nanotechnology-based approaches have been planned to satisfy the need
for targeted specificity of traditional agents of chemotherapeutics, in addition to early
recognition of malignant and precancerous lesions. Prostate cancer is the fifth most well--
known cancer worldwide and the second most usually detected cancer in men. Therefore,
there is a crucial need to improve therapeutic prospects for the diagnosis and treatment of
prostate cancer via the exploitation of the potential of nanomaterials for cell-targeted specificity
and improved primary diagnosis of precancerous tumors. The present review,
therefore, focuses on summarizing all prospective applications of nanotechnology in the
prognosis and diagnosis of prostate cancer, which would further help researchers to elucidate
a more potent therapeutic approach for the better management of prostate cancer in
the days ahead.
Withdrawal Notice: Overview of Enzyme Engineering Towards the
Production of Hyaluronic Acid with Tailored Molecular Weight
Authors: Ebrahimi Tahereh , Hosseini Kamran , Ahangari Hossein , Gholizadeh Pourya , Tarhriz Vahideh
Published: December 2021

The article has been withdrawn at the request of the author and the editor of the journal Current Protein and Peptide Science.

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Theracurmin Supplementation May be a Therapeutic Option for Older Patients
with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up
Study
Authors: Dost Fatma Sena , Kaya Derya , Ontan Mehmet Selman , Erken Neziha , Bulut Esra Ateş , Aydin Ali Ekrem , Isik Ahmet Turan
Published: December 2021

Background:

Alzheimer’s Disease (AD) is still a great global challenge and agents with
various mechanisms represent a promising therapeutic opportunity. Theracurmin, a very highly absorbable
curcumin formulation, was shown to improve memory and attention in non-demented people.

Objective:

The aim of the study was to investigate the effect of Theracurmin on disease course in
elderly patients with mild cognitive impairment (MCI) and AD.

Methods:

This follow-up study was performed retrospectively on 93 patients with MCI or AD. All patients underwent comprehensive geriatric assessment, including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA), clock-drawing test, activities of daily living (ADL), at baseline and end of the 6th-month. 19 patients with AD and 17 with MCI were treated with Theracurmin 180 mg/day per oral.

Results:

MMSE, MOCA and instrumental ADL scores decreased in AD patients not treated with
Theracurmin (p<0.001, p=0.011, and p=0.004, respectively), whereas these scores remained stable
in those treated with Theracurmin. This stabilization in the instrumental ADL was also observed in
MCI patients treated with Theracurmin. During the follow-up, three MCI patients who did not receive
Theracurmin progressed to AD, whereas only one patient progressed in those who received
it.

Conclusion:

Theracurmin seems to be a therapeutic option for elderly patients with AD and MCI
via providing stabilization of the disease course by preventing progressive loss in cognitive functions
and ADLs.
Structure-based De Novo Design and Docking Studies of 5(S)-Methyl-L-Proline
Containing Peptidomimetic Compounds as Dipeptidyl Peptidase-4
Inhibitors
Authors: Pathak Chirag D. , Gajjar Anuradha K.
Published: December 2021

Background:

Diabetes affects millions of people worldwide, with predicted numbers of
about 700 million adults affected by 2045. Among the several anti-diabetic drug therapies available in
the market, Dipeptidyl Peptidase-4 (DPP-4) inhibitors have emerged as a promising therapeutic approach
with scope for exploration in the segment of peptidomimetics.

Objective:

Series of proline-containing peptidomimetic compounds were designed and investigated for
their drug-likeness through Lipinski’s rule of five, lead-likeness through the rule of three, predictive
pharmacokinetic studies (absorption, distribution, metabolism, and excretion), and toxicity properties
through in-silico approaches. The designed compounds were evaluated for their interactions with
binding sites of the enzyme DPP-4 using an extra precision docking approach.

Methods:

Proline-containing peptidomimetic compounds were designed rationally. Drug-likeness and
lead-likeness properties were calculated using Schrödinger Maestro v11.2 software. ADME and toxicity
properties were predicted using PreADMET version 2.0. Docking study was performed using
Schrödinger Maestro v11.2 software, and ligands for the study were designed using MarvinSketch
software.

Results:

5(S)-methyl-L-proline containing 17 ligands were designed. All of them were found to obey
Lipinski’s rule of five. Compounds were found to have good ADME profile and low toxicity predictions.

Conclusion:

Four compounds were found to have good interactions with DPP-4 binding sites and
hence created the scope to develop DPP-4 inhibitors containing 5(S)-methyl-L-proline moiety.
Investigation of the Experimental Pharmacokinetics of the Bis-Chlorinated Bis-pyridinium Mono-aldoxime Cholinesterase Reactivator K-868 in Rats
Authors: Kalász Huba , Tekes Kornélia , Bátor György , Adeghate Jennifer , Adeghate Ernest , Darvas Ferenc , Fűrész József , Karvaly Gellért
Published: December 2021

Background:

The widespread use of organophosphorus compounds in agriculture and their existence in some military arsenals present continuous threats. Quaternary bis-pyridinium aldoximes are potent, highly polar cholinesterase reactivators and the most intensively studied candidate antidotes against poisoning with organophosphorus compounds.

Objective:

The in vivo experimental pharmacokinetic properties of K-868, a novel bis-chlorinated, bis-pyridinium mono-aldoxime are detailed and put in context with regard to similar compounds described earlier.

Methods:

Rats received 30 µmol K-868 i.m. and were sacrificed at various time points following treatment. Blood, cerebrospinal fluid and tear were collected, while the brains, eyes, kidneys, livers, lungs and testes were removed, dissected and homogenized. K-868 concentrations were determined using high performance liquid chromatography with ultraviolet absorption detection.

Results:

K-868 was detected in the eyes, kidneys, lungs and tear within 5 minutes in maximal serum concentrations attained 15 minutes following administration. Elimination was slow for K-868 which remained detectable at 120 minutes in the blood and the kidneys, and at 60 minutes in the eyes, lungs and tear following its administration. Nevertheless, its distribution was overall poor with areas under the 120-minute concentration curves (AUC120) showing close similarity in the blood and the kidneys, while reaching just approximately 5% of serum AUC120 in the eyes and lungs.

Conclusion:

K-868 is a potent candidate antidote against organophosphate poisoining with a prolonged presence in the circulation.
Potential Benefits of Tricetin in Medicine for the Treatment of Cancers
and Other Health-Related Disorders: Medicinal Importance and Therapeutic
Benefit
Authors: Patel Dinesh Kumar
Published: December 2021

Background:

Medicinal plants have been used in medicine for the treatment of numerous
diseases due to their medicinal properties and pharmacological activities. The popularity of herbal-
based drugs in the health sector has been increasing due to patient compliance and cost-effectiveness.
Herbal drugs derived from plant and animal sources have been used in the Ayurvedic,
Homeopathic, and Naturopathic systems of medicine. Medicinal plants have been used as fuel,
clothing, shelter, and food material worldwide since a very early age. Phytoconstituents are pure
plant chemicals found in different parts of the plant material. Flavonoids are an important class of
phytochemicals found in medicinal plants and their derived products.

Methods:

In order to understand the biological significance of tricetin, the present study collected
and analyzed scientific data on tricetin medicinal importance and pharmacological activities.
Literature databases such as Google, PubMed, Science Direct, and Scopus have been searched using
terms tricetin and flavonoid. All the scientific information has been collected from these
databases to know the biological importance of tricetin. Analytical data of tricetin have also been
collected and analyzed in the present work to know the isolation, separation, and identification procedure
of tricetin.

Results:

Scientific data analysis of different research work revealed the presence of tricetin in
Triticum dicoccum, Lathyrus pratensis, Eucalyptus globules, Thuja occidentalis, and Metasequoia
glyptostroboides. Scientific data analysis signified the biological importance of tricetin against different
forms of cancerous disorders, human osteosarcoma, glioblastoma multiforme, human breast
adenocarcinoma, human non-small cell lung cancer, and liver cancer. Scientific data analysis also
signified the biological potential of tricetin against inflammation, neurodegenerative diseases,
atherosclerosis, diabetes, and respiratory syncytial virus infection. Scientific data analysis revealed
the biological importance of tricetin against multidrug resistance and free radicals.

Conclusions:

Scientific data analysis revealed the biological importance and pharmacological activities
of tricetin against various forms of human disorders, including cancer, inflammation, neurodegeneration,
atherosclerosis, and diabetes.
The methodological concept of geoheritage valorization: Blidinje Nature Park – case study
Authors:   University of Sarajevo, Faculty of Science, Department of Geography, Sarajevo, Bosnia and Herzegovina, Banda Amra , Korjenić Aida ,   University of Sarajevo, Faculty of Science, Department of Geography, Sarajevo, Bosnia and Herzegovina, Temimović Emir ,   University of Sarajevo, Faculty of Science, Department of Geography, Sarajevo, Bosnia and Herzegovina, Čaušević Amra ,   University of Sarajevo, Faculty of Science, Department of Geography, Sarajevo, Bosnia and Herzegovina
Published: December 2021

U Bosni i Hercegovini nedostaje istraživanja na području valorizacije georaznolikosti, što je rezultiralo zanemarivanjem njezinih znanstvenih vrijednosti, ali i nedovoljnim razvojem geoturizma. Cilj je ovoga rada valorizirati odabrane geomorfolokalitete Parka prirode Blidinje s obzirom na njihovu geoturističku vrijednost. Primijenjeni metodološki koncept nastao je kao rezultat analize postojećih metodoloških koncepata valorizacije georaznolikosti, pri čemu su objedinjeni kriteriji za procjenu osnovne, dodane, zaštitne i turističke vrijednosti. Jedan od ciljeva rada jest i doprinos boljem razumijevanju i primjeni metodoloških koncepata turističke valorizacije, posebice u okviru zaštićenih prirodnih područja. Tijekom istraživanja izdvojena su 44 lokaliteta, a na osnovi rezultata preliminarne procjene kreirana je lista s ukupno 23 lokaliteta koji su valorizirani, od čega se njih osam izdvaja većom ocjenom od prosječne. Rezultati ovoga istraživanja upućuju na potencijal za razvoj ponude geoturizma PP Blidinje, čiji bi temelj trebali biti najbolje ocijenjeni geomorfolokaliteti.
Value of the Electronic Medical Record for Hospital Care: Update From the Literature
Authors: Uslu Aykut , Stausberg Jürgen
Published: December 2021

Background

Electronic records could improve quality and efficiency of health care. National and international bodies propagate this belief worldwide. However, the evidence base concerning the effects and advantages of electronic records is questionable. The outcome of health care systems is influenced by many components, making assertions about specific types of interventions difficult. Moreover, electronic records itself constitute a complex intervention offering several functions with possibly positive as well as negative effects on the outcome of health care systems.

Objective

The aim of this review is to summarize empirical studies about the value of electronic medical records (EMRs) for hospital care published between 2010 and spring 2019.

Methods

The authors adopted their method from a series of literature reviews. The literature search was performed on MEDLINE with “Medical Record System, Computerized” as the essential keyword. The selection process comprised 2 phases looking for a consent of both authors. Starting with 1345 references, 23 were finally included in the review. The evaluation combined a scoring of the studies’ quality, a description of data sources in case of secondary data analyses, and a qualitative assessment of the publications’ conclusions concerning the medical record’s impact on quality and efficiency of health care.

Results

The majority of the studies stemmed from the United States (19/23, 83%). Mostly, the studies used publicly available data (“secondary data studies”; 17/23, 74%). A total of 18 studies analyzed the effect of an EMR on the quality of health care (78%), 16 the effect on the efficiency of health care (70%). The primary data studies achieved a mean score of 4.3 (SD 1.37; theoretical maximum 10); the secondary data studies a mean score of 7.1 (SD 1.26; theoretical maximum 9). From the primary data studies, 2 demonstrated a reduction of costs. There was not one study that failed to demonstrate a positive effect on the quality of health care. Overall, 9/16 respective studies showed a reduction of costs (56%); 14/18 studies showed an increase of health care quality (78%); the remaining 4 studies missed explicit information about the proposed positive effect.

Conclusions

This review revealed a clear evidence about the value of EMRs. In addition to an awesome majority of economic advantages, the review also showed improvements in quality of care by all respective studies. The use of secondary data studies has prevailed over primary data studies in the meantime. Future work could focus on specific aspects of electronic records to guide their implementation and operation.
The Characteristics and Functionalities of Mobile Apps Aimed at Patients Diagnosed With Immune-Mediated Inflammatory Diseases: Systematic App Search
Authors: Romero-Jimenez Rosa , Escudero-Vilaplana Vicente , Chamorro-De-Vega Esther , Ais-Larisgoitia Arantza , Lobato Matilla Maria Elena , Herranz-Alonso Ana , Sanjurjo Maria
Published: December 2021

Background

Immune-mediated inflammatory diseases (IMIDs) are systemic conditions associated with a high social and health impact. New treatments have changed the prognosis of IMIDs and have increased patient autonomy in disease management. Mobile apps have enormous potential to improve health outcomes in patients with IMIDs. Although a large number of IMID apps are available, the app market is not regulated, and functionality and reliability remain uncertain.

Objective

Our aims are to review available apps for patients with IMIDs or caregivers and to describe the main characteristics and functionalities of these apps.

Methods

We performed an observational, cross-sectional, descriptive study of all apps for patients with IMIDs. Between April 5 and 14, 2021, we conducted a search of the App Store (iOS) and Play Store (Android) platforms. We used the names of the different IMIDs as search terms. The inclusion criteria were as follows: content related to IMIDs, English or Spanish language, and user population consisting of patients and health care consumers, including family and caregivers. The variables analyzed were as follows: app name, type of IMID, platform (Android or iOS), country of origin, language, category of the app, cost, date of the last update, size, downloads, author affiliation, and functionalities.

Results

We identified 713 apps in the initial search, and 243 apps met the criteria and were analyzed. Of these, 37% (n=90) were on Android, 27.2% (n=66) on iOS, and 35.8% (n=87) on both platforms. The most frequent categories were health and well-being/fitness apps (n=188, 48.5%) and medicine (n=82, 37.9%). A total of 211 (82.3%) apps were free. The mean time between the date of the analysis and the date of the most recent update was 18.5 (SD 19.3) months. Health care professionals were involved in the development of 100 (41.1%) apps. We found differences between Android and iOS in the mean time since the last update (16.2, SD 14.7 months vs 30.3, SD 25.7 months) and free apps (85.6% vs 75.8%; respectively). The functionalities were as follows: general information about lifestyles, nutrition, or exercises (n=135, 55.6%); specific information about the disease or treatment (n=102, 42%); recording of symptoms or adverse events (n=51, 21%); agenda/calendar (n=44, 18.1%); reminder medication (n=41, 16.9%); and recording of patient-reported outcomes (n=41, 16.9%). A total of 147 (60.5%) apps had more than one functionality.

Conclusions

IMID-related apps are heterogeneous in terms of functionality and reliability. Apps may be a useful complement to IMID care, especially inpatient education (their most frequent functionality). However, more than half of the IMID apps had not been developed by health care professionals or updated in the last year.
Building a Precision Medicine Delivery Platform for Clinics: The University of California, San Francisco, BRIDGE Experience
Authors: Bove Riley , Schleimer Erica , Sukhanov Paul , Gilson Michael , Law Sindy M , Barnecut Andrew , Miller Bruce L , Hauser Stephen L , Sanders Stephan J , Rankin Katherine P
Published: December 2021

Despite an ever-expanding number of analytics with the potential to impact clinical care, the field currently lacks point-of-care technological tools that allow clinicians to efficiently select disease-relevant data about their patients, algorithmically derive clinical indices (eg, risk scores), and view these data in straightforward graphical formats to inform real-time clinical decisions. Thus far, solutions to this problem have relied on either bottom-up approaches that are limited to a single clinic or generic top-down approaches that do not address clinical users’ specific setting-relevant or disease-relevant needs. As a road map for developing similar platforms, we describe our experience with building a custom but institution-wide platform that enables economies of time, cost, and expertise. The BRIDGE platform was designed to be modular and scalable and was customized to data types relevant to given clinical contexts within a major university medical center. The development process occurred by using a series of human-centered design phases with extensive, consistent stakeholder input. This institution-wide approach yielded a unified, carefully regulated, cross-specialty clinical research platform that can be launched during a patient’s electronic health record encounter. The platform pulls clinical data from the electronic health record (Epic; Epic Systems) as well as other clinical and research sources in real time; analyzes the combined data to derive clinical indices; and displays them in simple, clinician-designed visual formats specific to each disorder and clinic. By integrating an application into the clinical workflow and allowing clinicians to access data sources that would otherwise be cumbersome to assemble, view, and manipulate, institution-wide platforms represent an alternative approach to achieving the vision of true personalized medicine.
Condomless Anal Sex Associated With Heterogeneous Profiles Of HIV Pre-Exposure Prophylaxis Use and Sexual Activities Among Men Who Have Sex With Men: A Latent Class Analysis Using Sex Diary Data on a Mobile App (Preprint)
Authors: Yu Yi-Fang , Wu Huei-Jiuan , Ku Stephane Wen-Wei , Huang Po-Hsien , Li Chia-Wen , Huang Poyao , Strong Carol
Published: December 2021

BACKGROUND

New innovative technologies, such as mobile apps, have been developed to increase pre-exposure prophylaxis (PrEP) adherence and the use of log sex diaries. The contiguity of mobile apps reduces the recall bias that generally affects reported condom and PrEP use. However, none of the currently used mobile apps were designed for event-driven PrEP users, and few studies have demonstrated the potential usage of sex diary data to facilitate the understanding of the different HIV risks among heterogeneous profiles of sex diaries and PrEP use.

OBJECTIVE

We aim to discriminate the heterogeneous profiles of sex events and PrEP use and examine the risk of condomless anal sex among different types of sex events.

METHODS

We recruited 35 adult men who have sex with men from two medical centers in Taiwan since May 2020 and followed up for four months. Participants were on PrEP or willing to take PrEP. They were asked to log their sex events, PrEP use, and dosing regimens on a mobile app to improve their PrEP adherence. Latent class analysis was used to distinguish profiles of sex events and PrEP use. Indicators included correct intake of PrEP for each sex event, participants’ sexual positioning, partner’s HIV status, and age.

RESULTS

A total of 551 sex events were classified into three classes by latent class analysis: PrEP nonadherent flip-flopping (234/551, 42%), PrEP imperfect-adherent power bottoming (284/551, 52%), and PrEP adherent serodiscordant topping (33/551, 6%). “PrEP nonadherent flip-flopping” sex events were more likely to involve condomless anal sex than “PrEP imperfect-adherent power bottoming” (OR 1.83, 95% CI 1.03-3.25) after considering random intercepts for individuals, and this class needed to increase their PrEP adherence and use of condoms. “PrEP imperfect-adherent power bottoming” realized their own risk and packaged PrEP with condoms to protect themselves. Up to 99% (32/33) of sex events in “PrEP adherent serodiscordant topping” were protected by PrEP, but all of the sex events in this group were condomless.

CONCLUSIONS

Using the sex diary data could advance the capacity to identify high-risk groups. HIV prevention strategy should be more flexible and combine PrEP with condom use for future HIV prevention.
Incidence and Outcomes of Primary Cutaneous Anaplastic Large Cell Lymphoma: a SEER Population Based Study (Preprint)
Authors: Deb Pratik Q. , Hurley Harry J. , Cai Donghong , Bhate Chinmoy
Published: December 2021

BACKGROUND

Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is the second most common type of cutaneous lymphoma of T cell origin.

OBJECTIVE

To examine epidemiologic features and outcomes in PC-ALCL in the population of the United States.

METHODS

We identified patients with PC-ALCL from the Surveillance Epidemiology and End Results database from 1975 - 2017. Cases with only histological and immunohistochemical or molecular evidence of diagnosis were included in the study. Age, sex, and race-standardized incidence rates (IR) were calculated. Survival was assessed using Kaplan-Meier curves and Cox proportional hazards models.

RESULTS

Of all 569 cases documented as PC-ALCL, 93 patients fulfilled the inclusion criteria. We found the incidence of PC-ALCL to be highly correlated with increased age. There is a predominance of PC-ALCL in white male population. The survival analysis did not signify age of diagnosis, sex, or race as factors affecting the outcome for the patients. Although the site of primary tumor trends towards affecting survival, it does not meet statistical significance.

CONCLUSIONS

PC-ALCL is a rare malignancy predominantly affecting older white male in the United States. The increased age is highly correlated with disease development, however, neither the demographic characteristics nor the site of the primary tumor affects the outcome for the patients.

CLINICALTRIAL

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Accuracy of Store-and-Forward Teledermatology for the Diagnosis of Skin Cancer: The Nouvelle-Aquitaine Experience (Preprint)
Authors: Bui Colin , Doutre Marie-Sylvie , Taieb Alain , Beylot-Barry Marie , Joseph Jean-Philippe , Dorizy-Vuong Valérie
Published: December 2021

BACKGROUND

In Nouvelle-Aquitaine (a French region with a population of almost 6 million), the density of dermatologists is less than 3.8/100,000 inhabitants. This lack of dermatological care is delaying diagnosis and management, especially for skin cancer. The SmartDerm Project is a store-and-forward (SAF) teledermatology platform for primary care in Nouvelle-Aquitaine providing dermatological counselling to general practitioners (GPs).

OBJECTIVE

The main objective was to determine the concordance between the diagnosis of skin cancer made by dermatologists and the pathologists’ diagnosis.

METHODS

GPs in 3 pilot departments of Nouvelle-Aquitaine (Lot-Et-Garonne, Deux-Sèvres, Creuse) sent their dermatology requests using their smartphone, via an app called PAACO/Globule; dermatologists at the University Hospital of Bordeaux answered within 48-72 hours. Consecutive cases of skin cancer suspected by the referent dermatologists during the intervention were included, if the result of biopsy interpreted by a certified pathologist was available at the time of the study.

RESULTS

Among the 1727 requests, 163 (9%) concerned a possible diagnosis of skin cancer and were eligible. For 61 cases, the histopathological findings were not available. Eventually, 93 patients with a total of 102 skin lesions were included. Median age was 75 years (range 26-97 years), with 53% women. The skin lesions had progressed for 8 months on average (range 0.5-36 months). The median response time was 1 day (range 0-61 days); 65 days (range 1-667 days) elapsed on average between the SAF opinion and the histological sample. Histopathology diagnosed 83 malignant lesions (57 basal cell carcinomas, 69%; 18 squamous cell carcinomas, 22%; 6 melanomas, 7%; 1 cutaneous lymphoma, 1%; 1 secondary location of a primary cancer, 1%), 1 precancerous lesion, and 18 benign lesions. The concordance between the opinion of the referent dermatologist and the final pathological finding was 83% for nonmelanocytic lesions and 67% for melanocytic lesions.

CONCLUSIONS

This study showed the reliability of SAF teledermatology in the diagnosis of skin cancer, comparable to literature data in the absence of dermatoscopy. The median delay of about two months between request and histology was an improvement compared to the delay of usual appointments in the intervention area. The lack of data for 61 patients showed that SAF telemedicine requires better coordination and follow-up, especially for the management of skin cancer. With this reservation in mind, teledermatology offers an alternative answer for the triage of patients with skin cancer residing in areas with low medical density.