bluuebunny/crossref_metadata_2025 huggingface dataset:
Resilience in the Endurance Runner: The Role of Self-Regulatory Modes and Basic Psychological Needs
Authors: Diotaiuti Pierluigi , Corrado Stefano , Mancone Stefania , Falese Lavinia
Published: January 2021

Endurance sports certainly require an important and delicate task of mental and physical reintegration from the impact of the fatigue induced by the exertion of the sport performance. The topic of the resilience of athletes has been the theme of numerous studies, however, there are few specific works on the psychological resilience of runners. Our study aimed to investigate Resilience in Endurance Runner related to the role of Self-Regulation Modes and Basic Psychological Needs. Especially, the aim of our work was presenting a model where the gratification of the Needs of Autonomy and Competence and the level of Locomotion were the predictors of the two main components of Richardson’s resilience: Homeostatic and Resilient Reintegration. The present study involved 750 endurance runners, members of the Fidal (Italian Athletics Federation). A SEM analysis was performed combining into one explanatory model the following variables: Autonomy and Competence Satisfaction, Self-Regulatory Locomotion Mode, Homeostatic and Resilient Reintegration. The model showed overall acceptable fit measurements: χ2 = 872.152; CFI = 0.966; TLI = 0.952; RMSEA = 0.058. Results indicated that BPNs and SRMs are predictors of the level of resilience in endurance running athletes. In particular, Resilient Reintegration was mainly affected by Locomotion Mode (β = 0.379 for p < 0.005), which in turn received a major influence from Autonomy Satisfaction (β = 0.574 for p < 0.001). Homeostatic Recovery was found to be affected by Competence Satisfaction (β = 0.489 for p < 0.001). The study pointed out the importance of supporting in endurance runners the gratification of the needs of Autonomy and Competence as key factors capable of enhancing perseverance, timely recovery and psychophysical balance.
Suitability of Slower Growing Commercial Turkey Strains for Organic Husbandry in Terms of Animal Welfare and Performance
Authors: Olschewsky Anna , Riehn Katharina , Knierim Ute
Published: January 2021

Intensive turkey production with fast growing strains is often critically discussed regarding animal welfare problems. Studies evaluating the welfare status of both organic and less intensive selected turkey strains are limited, except in the slightly slower growing Kelly Broad Breast Bronze (Kelly). The aim of this study was to assess the welfare of turkeys from two strains with further decreased growth rate, Hockenhull Large Bronze (HoBr) and Hockenhull Black (HoBl), in comparison to Kelly under commercial organic conditions with 100% organic feed. Altogether 844 non-beak-trimmed male turkeys (274–288 per line) were reared and fattened in three replications with each six groups. On group level, use of resources in the 7, 16, and 25th week of life, mortality and feed conversion were recorded. Each bird was assessed with regard to plumage and skin condition as indicators of agonistic interactions, cannibalism and feather pecking, with regard to leg health, footpad, breast skin condition and, as performance indicators, live and carcass weight, utilization, daily weight gain and weights of valuable meat parts. The significantly slower growing HoBl showed slightly fewer malposition of the legs, reduced injury rates and less breast buttons, but a higher susceptibility to footpad dermatitis than Kelly turkeys. HoBr with a similar growth rate compared to Kelly had slightly more problems concerning walking ability and plumage damage, but also less breast buttons than Kelly turkeys. However, effect sizes were negligible (Φ < 0.10), except for the higher occurrence of footpad dermatitis and the reduced number of breast buttons in HoBl with small effect sizes (Φ = 0.20–0.24). Use of resources, prevalence of breast blisters and mortality, were not statistically different, although mortality rate was numerically lower in HoBl. Thus, for none of the studied strains clear benefits or disadvantages in terms of the birds' predisposition for welfare problems could be identified. Overall, prevalences of animal welfare problems were mostly lower than in comparable studies while performances were comparatively high. Therefore, turkeys from the studied strains appear to be suitable for organic rearing and fattening with 100% organic feed, given a good management.
Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
Authors: Detsika Maria G. , Lianos Elias A.
Published: January 2021

Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of carbon monoxide (CO). Recent studies uncovered a new cytoprotective role for heme oxygenase-1 (HO-1) by identifying a regulatory role on the complement control protein decay-accelerating factor. This is a key complement regulatory protein preventing dysregulation or overactivation of complement cascades that can cause kidney injury. Cell-specific targeting of HO-1 induction may, therefore, be a novel approach to attenuate complement-dependent forms of kidney disease.
Addendum: Anderson, M., et al. Grassland Management Affects Vegetation Structure, Bats and Their Beetle Prey. Diversity 2020, 12, 406
Authors: Anderson Max , Norton Lisa , Mathews Fiona
Published: January 2021

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Stopping Criterion during Rendering of Computer-Generated Images Based on SVD-Entropy
Authors: Buisine Jérôme , Bigand André , Synave Rémi , Delepoulle Samuel , Renaud Christophe
Published: January 2021

The estimation of image quality and noise perception still remains an important issue in various image processing applications. It has also become a hot topic in the field of photo-realistic computer graphics where noise is inherent in the calculation process. Unlike natural-scene images, however, a reference image is not available for computer-generated images. Thus, classic methods to assess noise quantity and stopping criterion during the rendering process are not usable. This is particularly important in the case of global illumination methods based on stochastic techniques: They provide photo-realistic images which are, however, corrupted by stochastic noise. This noise can be reduced by increasing the number of paths, as proved by Monte Carlo theory, but the problem of finding the right number of paths that are required in order to ensure that human observers cannot perceive any noise is still open. Until now, the features taking part in the human evaluation of image quality and the remaining perceived noise are not precisely known. Synthetic image generation tends to be very expensive and the produced datasets are high-dimensional datasets. In that case, finding a stopping criterion using a learning framework is a challenging task. In this paper, a new method for characterizing computational noise for computer generated images is presented. The noise is represented by the entropy of the singular value decomposition of each block composing an image. These Singular Value Decomposition (SVD)-entropy values are then used as input to a recurrent neural network architecture model in order to extract image noise and in predicting a visual convergence threshold of different parts of any image. Thus a new no-reference image quality assessment is proposed using the relation between SVD-Entropy and perceptual quality, based on a sequence of distorted images. Experiments show that the proposed method, compared with experimental psycho-visual scores, demonstrates a good consistency between these scores and stopping criterion measures that we obtain.
A Novel Co-Phase Power-Supply System Based on Modular Multilevel Converter for High-Speed Railway AT Traction Power-Supply System
Authors: Wu Si , Wu Mingli , Wang Yi
Published: January 2021

The existing problems of the traction power-supply system (i.e., the existence of the neutral section and the power quality problems) limit the development of railways, especially high-speed railways, which are developing rapidly worldwide. The existence of the neutral section leads to the speed loss and traction loss as well as mechanical failures, all of which threaten the fast and safe operation of the train and the system. Meanwhile, the power quality problems (e.g., the negative sequence current, the reactive power, and the harmonic) can bring a series of problems that cannot be ignored on the three-phase grid side. In response, many researchers have proposed co-phase power-supply schemes to solve these two problems simultaneously. Given that the auto-transformer (AT) power-supply mode has become the main power-supply mode for the high-speed railway traction power-supply system, it has a bright future following the rapid development of the high-speed railway. In addition, there is no co-phase power-supply scheme designed for AT power-supply mode in the existing schemes. Therefore, the main contribution of this paper is to propose a specifically designed power-supply mode more suitable for the AT, as well as to establish the control systems for the rectifier side and the inverter side. In addition, for the proposed scheme, the operation principle is analyzed, the mathematical model is built, and the control system is created, and its functionality is verified by simulation, and its advantages are compared and summarized finally. The result proves that it can meet functional requirements. At the same time, compared with the existing co-phase power-supply scheme, it saves an auto-transformer in terms of topology, reduces the current stress by 10.9% in terms of the current stress of the switching device, and reduces the power loss by 0.25% in terms of the entire system power loss, which will result in a larger amount of electricity being saved. All of this makes it a more suitable co-phase power-supply scheme for the AT power-supply mode.
Assessment of Training Aircraft Crew Exposure to Electromagnetic Fields Caused by Radio Navigation Devices
Authors: Michałowska Joanna , Pytka Jarosław , Tofil Arkadiusz , Krupski Piotr , Puzio Łukasz
Published: January 2021

The paper depicts research concerning the value of the electric component of the electromagnetic (EM) energy determined by the NHT3DL meter by Microrad with the 01E measuring probe during a number of flights made by Aero AT-3 R100, Cessna C172, and Tecnam P2006T fixed wing aircrafts and a Robinson R44 Raven helicopter. The point of reference for the recorded measurement was the normative limits of the electromagnetic field (EMF), which can influence a pilot in the course of a flight. Selected studies of the maximum value recorded by the meter was E = 10.66 V/m when landing at an airfield equipped with the VHF (Very High Frequency) omnidirectional radio range (VOR) approach system. Particular attention has been paid to changes in electric field intensity during the operation and their effects on the type of radio navigation systems as well as communication with the airfield control tower. The obtained results were validated in the Statistica 13.3 software for the purpose of a detailed stochastic analysis of the tested values. Results obtained are subject to the mandatory requirements of Directive 2013/35/EU as well as to the relevant regulations in Poland.
Assessment of Geothermal Resources in the North Jiangsu Basin, East China, Using Monte Carlo Simulation
Authors: Wang Yibo , Wang Lijuan , Bai Yang , Wang Zhuting , Hu Jie , Hu Di , Wang Yaqi , Hu Shengbiao
Published: January 2021

Geothermal energy has been recognized as an important clean renewable energy. Accurate assessment of geothermal resources is an essential foundation for their development and utilization. The North Jiangsu Basin (NJB), located in the Lower Yangtze Craton, is shaped like a wedge block of an ancient plate boundary and large-scale carbonate thermal reservoirs are developed in the deep NJB. Moreover, the NJB exhibits a high heat flow background because of its extensive extension since the Late Mesozoic. In this study, we used the Monte Carlo method to evaluate the geothermal resources of the main reservoir shallower than 10 km in the NJB. Compared with the volumetric method, the Monte Carlo method takes into account the variation mode and uncertainties of the input parameters. The simulation results show that the geothermal resources of the sandstone thermal reservoir in the shallow NJB are very rich, with capacities of (6.6–12) × 1020 J (mean 8.6 × 1020 J), (5.1–16) × 1020 J (mean 9.1 × 1020 J), and (3.2–11) × 1020 J (mean 6.6 × 1020 J) for the Yancheng, Sanduo and Dai’nan sandstone reservoir, respectively. In addition, the capacity of the geothermal resource of the carbonate thermal reservoir in the deep NJB is far greater than the former, reaching (9.9–15) × 1021 J (mean 12 × 1021 J). The results indicate capacities of a range value of (1.2–1.7) × 1021 J (mean 1.4 × 1022 J) for the whole NJB (<10 km).
An Integrated Comparative Assessment of Coal-Based Carbon Capture and Storage (CCS) Vis-à-Vis Renewable Energies in India’s Low Carbon Electricity Transition Scenarios
Authors: Hiremath Mitavachan , Viebahn Peter , Samadi Sascha
Published: January 2021

Roadmaps for India’s energy future foresee that coal power will continue to play a considerable role until the middle of the 21st century. Among other options, carbon capture and storage (CCS) is being considered as a potential technology for decarbonising the power sector. Consequently, it is important to quantify the relative benefits and trade-offs of coal-CCS in comparison to its competing renewable power sources from multiple sustainability perspectives. In this paper, we assess coal-CCS pathways in India up to 2050 and compare coal-CCS with conventional coal, solar PV and wind power sources through an integrated assessment approach coupled with a nexus perspective (energy-cost-climate-water nexus). Our levelized costs assessment reveals that coal-CCS is expensive and significant cost reductions would be needed for CCS to compete in the Indian power market. In addition, although carbon pricing could make coal-CCS competitive in relation to conventional coal power plants, it cannot influence the lack of competitiveness of coal-CCS with respect to renewables. From a climate perspective, CCS can significantly reduce the life cycle GHG emissions of conventional coal power plants, but renewables are better positioned than coal-CCS if the goal is ambitious climate change mitigation. Our water footprint assessment reveals that coal-CCS consumes an enormous volume of water resources in comparison to conventional coal and, in particular, to renewables. To conclude, our findings highlight that coal-CCS not only suffers from typical new technology development related challenges—such as a lack of technical potential assessments and necessary support infrastructure, and high costs—but also from severe resource constraints (especially water) in an era of global warming and the competition from outperforming renewable power sources. Our study, therefore, adds a considerable level of techno-economic and environmental nexus specificity to the current debate about coal-based large-scale CCS and the low carbon energy transition in emerging and developing economies in the Global South.
Energy-Efficient Device Discovery Mechanism for Device-to-Device Communications in 5G Networks
Authors: Li Mingfu , Tsai Hsin-Ling
Published: January 2021

The conventional direct device discovery scheme which uses the random access protocol and encounters contentions or collisions is highly energy and time-consuming. To reduce the energy consumption of user equipments (UEs), this work proposes a two-phase hybrid device discovery mechanism for device-to-device (D2D) communications. In the first phase, the evolved packet core (EPC) or base station (BS) uses the location information of UEs to judge whether two UEs are able to establish a D2D link. In the second phase, UEs use Wi-Fi Direct to discover their target UEs. The BS directly assigns UEs’ states and allocates appropriate Wi-Fi channels to UEs. UEs no longer have to search or listen to all channels, thus reducing the discovery delay. The proposed mechanism saves cellular spectrum resources because it uses unlicensed bands for D2D discovery and communications. The performance of the proposed hybrid D2D discovery mechanism is also theoretically analyzed in this paper. Evaluation results show that the proposed D2D discovery mechanism has better performance in terms of energy consumption, discovery delay and discovery success rate, compared with the conventional direct D2D discovery scheme, especially in the network scenarios with smaller cells such as 5G networks. Additionally, the analytic results coincide with simulation results, demonstrating that our theoretic analysis is accurate.
Growth Kinetics and Optical Properties of CsPbBr3 Perovskite Nanocrystals
Authors: Kim Sung , Park Kyoung-Duck , Lee Hong
Published: January 2021

We synthesized CsPbBr3 perovskite nanocrystals (NCs) at different reaction temperatures and tracked their growth kinetics on the basis of their optical properties and estimated size. The energies of the absorption and fluorescence (FL) peaks with increasing reaction temperature for the CsPbBr3 perovskite NCs were tuned within the regions of 2.429–2.570 eV and 2.391–2.469 eV, respectively, depending on size of the NCs (9.9–12.5 nm). The Stokes shifts of CsPbBr3 perovskite NCs with increasing NC size decreased from 101 meV to 38 meV. The full-width at half-maximum of the FL peaks for the CdSe NCs decreased from 150 meV to 90 meV because of the improved size uniformity of the CsPbBr3 perovskite NCs. The energy spacing of CsPbBr3 perovskite NCs synthesized at various reaction temperatures was calculated from Tauc plots; this information is critical for determining the bandgap energy and enables the size of the CsPbBr3 perovskite NCs to be estimated using the effective mass approximation.
Scenario Analysis for Selecting Sewage Sludge-to-Energy/Matter Recovery Processes
Authors: Facchini Francesco , Mummolo Giovanni , Vitti Micaela
Published: January 2021

The sewage sludges are the byproducts of the wastewater treatment. The new perspective of the wastewater value chain points to a sustainable circular economy approach, where the residual solid material produced by sewage sludge treatments is a resource rather than a waste. A sewage sludge treatment system consists of five main phases; each of them can be performed by different alternative processes. Each process is characterized by its capability to recover energy and/or matter. In this paper, a state of the art of the sludge-to-energy and sludge-to-matter treatments is provided. Then, a scenario analysis is developed to identify suitable sewage sludge treatments plants that best fit the quality and flowrate of sewage sludge to be processed while meeting technological and economic constraints. Based on the scientific literature findings and experts’ opinions, the authors identify a set of reference initial scenarios and the corresponding best treatments’ selection for configuring sewage sludge treatment plants. The scenario analysis reveals a useful reference technical framework when circular economy goals are pursued. The results achieved in all scenarios ensure the potential recovery of matter and/or energy from sewage sludges processes.
Fault Detection in DC Microgrids Using Short-Time Fourier Transform
Authors: Grcić Ivan , Pandžić Hrvoje , Novosel Damir
Published: January 2021

Fault detection in microgrids presents a strong technical challenge due to the dynamic operating conditions. Changing the power generation and load impacts the current magnitude and direction, which has an adverse effect on the microgrid protection scheme. To address this problem, this paper addresses a field-transform-based fault detection method immune to the microgrid conditions. The faults are simulated via a Matlab/Simulink model of the grid-connected photovoltaics-based DC microgrid with battery energy storage. Short-time Fourier transform is applied to the fault time signal to obtain a frequency spectrum. Selected spectrum features are then provided to a number of intelligent classifiers. The classifiers’ scores were evaluated using the F1-score metric. Most classifiers proved to be reliable as their performance score was above 90%.
Constrained versus Unconstrained Rational Inattention
Authors: Azrieli Yaron
Published: January 2021

The rational inattention literature is split between two versions of the model: in one, mutual information of states and signals are bounded by a hard constraint, while, in the other, it appears as an additive term in the decision maker’s utility function. The resulting constrained and unconstrained maximization problems are closely related, but, nevertheless, their solutions differ in certain aspects. In particular, movements in the decision maker’s prior belief and utility function lead to opposite comparative statics conclusions.
Burnout among Probation Officers in Poland and the Role of Preferred Styles of Coping with Stress
Authors: Wirkus Łukasz , Babicka-Wirkus Anna , Opora Robert , Stasiak Krzysztof
Published: January 2021

The current article examined the relationship between preferred styles of coping with stress and occupational burnout among probation officers in Poland. The probation system in Poland is unique in comparison to similar organizations in Europe and the world. It is characterized by two separate specializations in the area of performed tasks: probation officers for adults and for family and juvenile clients. The main purpose of the study was to assess the relationship between occupational burnout levels among probation officers (n = 390) and their preferred styles of coping with stress. Two psychological tools were used in the study: the Maslach Burnout Inventory (MBI) and the Coping Inventory for Stressful Situations (CISS). A linear regression analysis was carried out to explain the variance in occupational burnout. Occupational burnout was the dependent variable and the CISS scales were the predictors. In order to test the moderating role of the sociodemographic factors of gender, work experience, age, and probation specialization in the relationship between coping styles and occupational burnout, a range of moderation analyses using Hayes’ PROCESS macro on SPSS was carried out.
Study of Psychosocial and Academic Indicators in Young Adults from Andalucía, Spain
Authors: Espejo-Garcés Tamara , Cachón-Zagalaz Javier , Zurita-Ortega Félix , González-Valero Gabriel , Ubago-Jiménez José Luis
Published: January 2021

Background: The university years bring a great deal of vital changes. In addition, psycho-social factors play a key role in university students’ development and their consumption of harmful substances. The aim is to analyse academic performance according to psychosocial factors, self-concept, emotional intelligence and harmful substance consumption in a sample of future Physical Education teachers. Methods: The present study was carried out with a sample of 775 undergraduate students who were studying for the Primary Education Degree in Physical Education in Andalusia, Spain. The main instruments used include an ad hoc questionnaire, the Self-Concept Form-5 test, Alcohol Use Disorders Identification Test, Fagerström Test for Nicotine Dependence and the Emotional Intelligence Inventory adapted to Sport. Results: The results show that young people who have a greater general self-concept and self-emotional management are those who access the university degree through Vocational Training. In relation to the average record mark, it was observed that participants with marks of notable and outstanding obtained higher scores in general self-concept, academic dimension and hetero-emotional management. Those with grades of passed and outstanding were those with higher levels in the physical dimension of self-concept and emotional use. In relation to receiving a scholarship to study, it has been shown that those university students who do perceive it have higher levels in most of the dimensions of emotional intelligence and self-concept. Conclusions: Finally, the harmful substances did not show significant relationships with academic factors, except between tobacco and the average mark of the file.
Value Conflict, Lack of Rewards, and Sense of Community as Psychosocial Risk Factors of Burnout in Communication Professionals (Press, Radio, and Television)
Authors: Gascón Santiago , Fueyo-Díaz Ricardo , Borao Luis , Leiter Michael P. , Fanlo-Zarazaga Álvaro , Oliván-Blázquez Bárbara , Aguilar-Latorre Alejandra
Published: January 2021

Journalists are at particular risk of work-related stress and burnout. The objective of this study is to describe and analyze the principal factors involved in the appearance of burnout in communication professionals, as well as the possible interactions between them and with self-reported health, and to observe whether the variables involved are the same in different types of environments. To achieve this objective, 292 participants answered the following measurement instruments: Demographic and labor datasheet; Maslach Burnout Inventory (MBI General survey); Areas of Worklife Scale (AWS); and General Health Questionnaire (GHQ -12). The results were the following: Emotional Exhaustion (EE) shows direct correlation and statistical significance with the other two burnout dimensions, Depersonalization (DP) and Personal Accomplishment (PA), also with health perception variables and inverse and statistical significance with the workload, control, rewards, community, fairness, and values. A multiple linear regression model shows workload and values as inverse EE predictors, which confirms a burnout process in which EE contributes as the main dimension in DP and is shown to be a precursor of PA, itself. When comparing different types of media, journalists who work in institutional press offices presented significantly lower scores in PA and higher in control, rewards, community, justice, and values. Therefore, further research should be carried out in order to analyze the protective role of these variables regarding PA and burnout.
Parent Feeding Practices in the Context of Food Insecurity
Authors: Arlinghaus Katherine R. , Laska Melissa N.
Published: January 2021

The process of feeding is complex and highly dependent on parent, child, social, and environmental factors. Given the rising rates of food insecurity and concomitant poor nutrition and health, the purpose of this article was to outline the important and complex ways in which the context of food insecurity can impact parent feeding practices. Key factors discussed here include the impact of food insecurity on: expectations for motherhood, structural constraints, stress and depression, parents’ perceptions of health and child weight, and intergenerational transmission of parent feeding practices. Future research needs are also identified and discussed.
Survival Outcomes and Predictors for Patients who Failed Chemoradiotherapy/Radiotherapy and Underwent Salvage Total Laryngectomy
Authors: Tsai Ming-Hsien , Chuang Hui-Ching , Lin Yu-Tsai , Huang Tai-Lin , Fang Fu-Min , Lu Hui , Chien Chih-Yen
Published: January 2021

Background: To assess the presence of adverse pathological features at the time of salvage total laryngectomy (TL) associated with oncologic outcome. Methods: Ninety patients with persistent/locally recurrent disease and who subsequently underwent salvage TL after definitive treatment by radiation alone (RTO) or concurrent chemo-radiation (CCRT) from 2009 to 2018 were retrospectively enrolled. Kaplan–Meier methods were used to estimate overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Results: Lymphovascular invasion (LVI), perineural invasion, positive margin, and stage IV disease were associated with worse survival in the univariate analysis. In the multivariate analysis, the presence of LVI and positive margin were both independent negative predictors in OS (LVI: adjusted hazard ratio (aHR) = 2.537, 95% CI: 1.163–5.532, p = 0.019; positive margin: aHR = 5.68, 95% CI: 1.996–16.166, p = 0.001), DSS (LVI: aHR = 2.975, 95% CI: 1.228–7.206, p = 0.016); positive margin: aHR = 11.338, 95% CI: 2.438–52.733, p = 0.002), and DFS (LVI: aHR 2.705, 95% CI: 1.257–5.821, p = 0.011; positive margin (aHR = 6.632, 95% CI: 2.047–21.487, p = 0.002). Conclusions: The presence of LVI and positive margin were both associated with poor OS, DSS, and DFS among patients who underwent salvage TL after failure of RTO/CCRT. The role of adjuvant therapy for high-risk patients after salvage TL to improve the chance of survival requires more investigation in the future.
Socioeconomic Costs of Dementia Based on Utilization of Health Care and Long-Term-Care Services: A Retrospective Cohort Study
Authors: Han Eun-Jeong , Lee JungSuk , Cho Eunhee , Kim Hyejin
Published: January 2021

This study examined the socioeconomic costs of dementia based on the utilization of healthcare and long-term care services in South Korea. Using 2016 data from two national insurance databases and a survey study, persons with dementia were categorized into six groups based on healthcare and long-term care services used: long-term care insurance users with home- and community-based services (n = 93,346), nursing home services (n = 69,895), and combined services (n = 16,068); and long-term care insurance non-users cared for by family at home (n = 192,713), living alone (n = 19,526), and admitted to long-term-care hospitals (n = 65,976). Their direct and indirect costs were estimated. The total socioeconomic cost of dementia was an estimated US$10.9 billion for 457,524 participants in 2016 (US$23,877 per person). Among the six groups, the annual per-person socioeconomic cost of dementia was lowest for long-term care insurance users who received home- and community-based services (US$21,391). It was highest for long-term care insurance non-users admitted to long-term care hospitals (US$26,978). Effective strategies are necessary to promote long-term care insurance with home- and community-based services to enable persons with dementia to remain in their communities as long as possible while receiving cost-efficient, quality care.
Children of Parents with a Mental Illness: Predictors of Health-Related Quality of Life and Determinants of Child–Parent Agreement
Authors: Radicke Alina , Barkmann Claus , Adema Bonnie , Daubmann Anne , Wegscheider Karl , Wiegand-Grefe Silke
Published: January 2021

(1) Background: Health-related quality of life (HRQoL) is frequently reduced in children of parents with a mental illness (COPMI). Child self- and parent proxy-ratings vary with raters’ characteristics and facets of HRQoL. This study aimed at analyzing risk and protective factors associated with HRQoL in COPMI, and at examining the magnitude, direction, and predictors of child–parent agreement. (2) Methods: Analyses were based on baseline data of the German CHIMPS (children of parents with a mental illness) project with n = 134 parents diagnosed with mental illness and n = 198 children and adolescents aged 8 to 18 years. (3) Results: Both children and parents reported significantly lower HRQoL than the reference population, particularly for the child’s physical and psychological well-being. Parents’ proxy-report indicated a lower HRQoL than the children’s self-report. Child and parental psychopathology, social support, and the child’s age significantly predicted HRQoL. Interrater agreement was satisfactory and better for observable aspects like physical well-being and school environment. The child’s gender-identity and mental health significantly predicted child–parent agreement. (4) Conclusions: Parental psychopathology significantly reduces children’s HRQoL. Interventions should promote resilience in children by targeting risk and protective factors. Child–parent agreement emphasizes the need to obtain both self- and proxy-reports, whenever possible.
General Parenting and Hispanic Mothers’ Feeding Practices and Styles
Authors: Power Thomas G. , Fisher Jennifer O. , O'Connor Teresia M. , Micheli Nilda , Papaioannou Maria A. , Hughes Sheryl O.
Published: January 2021

Previous research has shown that general parenting styles, general parenting dimensions, maternal feeding styles, and maternal feeding practices all show specific relationships with the weight status of young children. This study examined the relationships between general parenting and maternal feeding styles/practices in a sample of 187 Hispanic mothers with low incomes. As part of a larger study, mothers of preschool children were recruited through Head Start programs and completed validated questionnaires assessing their general parenting, feeding styles, and feeding practices. Results identified numerous associations between general parenting dimensions and specific feeding practices: i.e., maternal nurturance was positively associated with healthy eating guidance and feeding responsiveness; inconsistency was positively associated with restriction for weight and promotion of overconsumption; follow through on discipline was positively associated with monitoring, healthy eating guidance, and feeding responsiveness; and family organization was positively associated with monitoring and healthy eating guidance. General parenting styles were associated with feeding practices as well, with authoritative mothers showing the highest levels of healthy eating guidance and authoritarian mothers showing the lowest levels of monitoring. There were no significant associations between mothers’ general parenting styles and mothers’ feeding styles. Implications of these findings for the prevention of childhood obesity are considered.
Can Innovation Agglomeration Reduce Carbon Emissions? Evidence from China
Authors: Zhang Jianqing , Yu Haichao , Zhang Keke , Zhao Liang , Fan Fei
Published: January 2021

Innovation agglomeration plays a decisive role in improving the input–output scale and marginal output efficiency of factors. This paper takes carbon emissions as the unexpected output and energy consumption as the input factor into the traditional output density model. The dynamic spatial panel Durbin model is used to analyze the mechanism for innovation agglomeration and energy intensity to affect carbon emissions from 2004 to 2017 in thirty Chinese provinces. Then, we test the possible mediating effect of energy intensity between innovation agglomeration and carbon emissions. The major findings are as follows. (1) The carbon emission intensity has time-dependence and positive spatial spillover effect. That is, there is a close correlation between current and early carbon emissions, and there is also a high-degree correlation between regional and surrounding areas’ carbon emissions. (2) Carbon emissions keep a classical inverted U-shaped relation with innovation agglomeration, as well as with energy intensity. However, the impact of innovation agglomeration on carbon emissions in inland regions of China does not appear on the right side of the inverted U-shaped curve, while carbon emissions are subject to a positive nonlinear promoting effect from energy intensity. (3) When the logarithm of innovation agglomeration is more than 3.0309, it first shows the inhibition effect on energy intensity. With the logarithm of innovation agglomeration exceeding 5.0100, it will show the dual effect of emission reduction and energy conservation. (4) Energy intensity could work as the intermediary variable of innovation agglomeration’s influence on carbon emissions. Through its various positive externalities, innovation agglomeration can produce a direct impact on carbon emissions, and through energy intensity, it can also affect carbon emissions indirectly.
Multilevel Social Mechanisms of Post-Disaster Depression
Authors: Wind Tim R. , Kawachi Ichiro , Komproe Ivan H.
Published: January 2021

This exploratory study empirically shows how community social capital is related to post-disaster depression, whereas most disaster mental health research has focused on posttraumatic stress disorder. We tested the validity of earlier found multilevel social and individual mechanisms of posttraumatic stress for symptoms of post-disaster depression. We used data (n = 231) from a community study after a flood in Morpeth (2008), a rural town in northern England. At the salutary community level, our multilevel analyses showed that, in communities with high social capital, individuals employ less individual social support and coping effort, which protects individuals from developing symptoms of depression. Yet, on the ‘dark’ individual level of our model, we found that perceiving the disaster as less traumatic after a year was related to more feelings of depression in contrast to previous findings for posttraumatic stress. Our explanation of this finding is that, when the appraisal of the disaster as threatening fades into the background, individuals may perceive the full scope of the disaster aftermath and start to feel depressed. We also found that more social support is related to more depression. Although depressed people may attract or receive more social support, this social support can paradoxically become disabling by reinforcing a sense of dependence, thereby undermining self-esteem and leading to feelings of helplessness. Our results imply that to curb post-disaster depression, boosting community level social capital may be an important starting point for building resilience. At the same time, interventionists need to identify risk groups for whom the stressful experience becomes less intrusive and who experience the burden of dependency on an unequal relationship with ones’ social inner circle.
Cost of Venous Thromboembolic Disease in Patients with Lung Cancer: COSTECAT Study
Authors: Rubio-Salvador Ana Rosa , Escudero-Vilaplana Vicente , Marcos Rodríguez José Antonio , Mangues-Bafalluy Irene , Bernardez Beatriz , García Collado Carlos , Collado-Borrell Roberto , Alvarado Fernández María Dolores , Chacón López-Muñiz José Ignacio , Yébenes Cortés María , Gómez Barrera Manuel , Calleja-Hernández Miguel Ángel
Published: January 2021

Background: Patients with lung cancer (LC) are at significantly higher risk of developing venous thromboembolism (VTE), which may lead to increased use of health resources and the cost of the disease management. The main aim of the study was to determine the cost of the management of VTE events in patients with LC treated with Low Molecular Weight Heparins (LMWH) in Spain. Methods: Costecat was an observational, ambispective pharmacoeconomic study. Patients with LC, with a first episode of VTE (symptomatic or incidental) in treatment with LMWH, were recruited from six third-level hospitals and followed up for six months. Sociodemographic, clinical and resource use variables of VTE-related implications and its treatment were collected. Direct healthcare costs and direct non-healthcare costs were recorded. Data collection was documented in an electronic case report. Costs (€2018) were estimated from the healthcare perspective. Statistical analysis was performed using the statistical program R 3.4.3 version (30 November 2017). Results: Forty-seven patients were included. Mean age was 65.4 years, 66.0% were male. The percentage of patients with LC who had metastatic disease was 78.7%. Twenty-three patients (48.9%) needed hospital admissions due to thromboembolic episode. Total average cost of patients with cancer associated VTE (CAT) was €10,969.6 per patient/semester. The hospitalizations represent 65.8% of total costs (7207.3 € SD 13,996.9 €), followed by LMWH therapy which represents 18.6% (2033.8 € SD:630.5 €). Conclusions: Venous thromboembolism episodes induce an economic impact on patients and healthcare systems. Direct healthcare costs are the major burden of the total cost, in which hospitalizations are the main drivers of cost.
Modes of Transmission of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) and Factors Influencing on the Airborne Transmission: A Review
Authors: Delikhoon Mahdieh , Guzman Marcelo I. , Nabizadeh Ramin , Norouzian Baghani Abbas
Published: January 2021

The multiple modes of SARS-CoV-2 transmission including airborne, droplet, contact, and fecal–oral transmissions that cause coronavirus disease 2019 (COVID-19) contribute to a public threat to the lives of people worldwide. Herein, different databases are reviewed to evaluate modes of transmission of SARS-CoV-2 and study the effects of negative pressure ventilation, air conditioning system, and related protection approaches of this virus. Droplet transmission was commonly reported to occur in particles with diameter >5 µm that can quickly settle gravitationally on surfaces (1–2 m). Instead, fine and ultrafine particles (airborne transmission) can stay suspended for an extended period of time (≥2 h) and be transported further, e.g., up to 8 m through simple diffusion and convection mechanisms. Droplet and airborne transmission of SARS-CoV-2 can be limited indoors with adequate ventilation of rooms, by routine disinfection of toilets, using negative pressure rooms, using face masks, and maintaining social distancing. Other preventive measures recommended include increasing the number of screening tests of suspected carriers of SARS-CoV-2, reducing the number of persons in a room to minimize sharing indoor air, and monitoring people’s temperature before accessing a building. The work reviews a body of literature supporting the transmission of SARS-CoV-2 through air, causing COVID-19 disease, which requires coordinated worldwide strategies.
The Association between Hepatic Encephalopathy and Diabetic Encephalopathy: The Brain-Liver Axis
Authors: Cheon So Yeong , Song Juhyun
Published: January 2021

Hepatic encephalopathy (HE) is one of the main consequences of liver disease and is observed in severe liver failure and cirrhosis. Recent studies have provided significant evidence that HE shows several neurological symptoms including depressive mood, cognitive dysfunction, impaired circadian rhythm, and attention deficits as well as motor disturbance. Liver disease is also a risk factor for the development of diabetes mellitus. Diabetic encephalopathy (DE) is characterized by cognitive dysfunction and motor impairment. Recent research investigated the relationship between metabolic changes and the pathogenesis of neurological disease, indicating the importance between metabolic organs and the brain. Given that a diverse number of metabolites and changes in the brain contribute to neurologic dysfunction, HE and DE are emerging types of neurologic disease. Here, we review significant evidence of the association between HE and DE, and summarise the common risk factors. This review may provide promising therapeutic information and help to design a future metabolic organ-related study in relation to HE and DE.
Tryptophan Derivatives by Saccharomyces cerevisiae EC1118: Evaluation, Optimization, and Production in a Soybean-Based Medium
Authors: Dei Cas Michele , Vigentini Ileana , Vitalini Sara , Laganaro Antonella , Iriti Marcello , Paroni Rita , Foschino Roberto
Published: January 2021

Given the pharmacological properti es and the potential role of kynurenic acid (KYNA) in human physiology and the pleiotropic activity of the neurohormone melatonin (MEL) involved in physiological and immunological functions and as regulator of antioxidant enzymes, this study aimed at evaluating the capability of Saccharomyces cerevisiae EC1118 to release tryptophan derivatives (dTRPs) from the kynurenine (KYN) and melatonin pathways. The setting up of the spectroscopic and chromatographic conditions for the quantification of the dTRPs in LC-MS/MS system, the optimization of dTRPs’ production in fermentative and whole-cell biotransformation approaches and the production of dTRPs in a soybean-based cultural medium naturally enriched in tryptophan, as a case of study, were included in the experimental plan. Variable amounts of dTRPs, with a prevalence of metabolites of the KYN pathway, were detected. The LC-MS/MS analysis showed that the compound synthesized at highest concentration is KYNA that reached 9.146 ± 0.585 mg/L in fermentation trials in a chemically defined medium at 400 mg/L TRP. Further experiments in a soybean-based medium confirm KYNA as the main dTRPs, whereas the other dTRPs reached very lower concentrations. While detectable quantities of melatonin were never observed, two MEL isomers were successfully measured in laboratory media.
Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections
Authors: Batoni Giovanna , Maisetta Giuseppantonio , Esin Semih
Published: January 2021

It is widely recognized that many chronic infections of the human body have a polymicrobial etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis patients, periodontitis, otitis, urinary tract infections and even a proportion of systemic infections. The treatment of mixed infections poses serious challenges in the clinic. First, polymicrobial communities of microorganisms often organize themselves as biofilms that are notoriously recalcitrant to antimicrobial therapy and clearance by the host immune system. Secondly, a plethora of interactions among community members may affect the expression of virulence factors and the susceptibility to antimicrobials of individual species in the community. Therefore, new strategies able to target multiple pathogens in mixed populations need to be urgently developed and evaluated. In this regard, antimicrobial or host defense peptides (AMPs) deserve particular attention as they are endowed with many favorable features that may serve to this end. The aim of the present review is to offer a comprehensive and updated overview of studies addressing the therapeutic potential of AMPs in mixed infections, highlighting the opportunities offered by this class of antimicrobials in the fight against polymicrobial infections, but also the limits that may arise in their use for this type of application.
Application of Raman Spectroscopic Imaging to Assess the Structural Changes at Cell-Scaffold Interface
Authors: Kalisz Grzegorz , Przekora Agata , Kazimierczak Paulina , Gieroba Barbara , Jedrek Michal , Grudzinski Wojciech , Gruszecki Wieslaw I. , Ginalska Grazyna , Sroka-Bartnicka Anna
Published: January 2021

Raman spectroscopic imaging and mapping were applied to characterise three-compound ceramic composite biomaterial consisting of chitosan, β-1,3-d-glucan (curdlan) and hydroxyapatite (HA) developed as a bone tissue engineering product (TEP). In this rapidly advancing domain of medical science, the urge for quick, reliable and specific method for products evaluation and tissue–implant interaction, in this case bone formation process, is constantly present. Two types of stem cells, adipose-derived stem cells (ADSCs) and bone marrow-derived stem cells (BMDSCs), were cultured on composite surface. Raman spectroscopic imaging provided advantageous information on molecular differences and spatial distribution of compounds within and between the cell-seeded and untreated samples at a microscopic level. With the use of this, it was possible to confirm composite biocompatibility and bioactivity in vitro. Deposition of HA and changes in its crystallinity along with protein adsorption proved new bone tissue formation in both mesenchymal stem cell samples, where the cells proliferated, differentiated and produced biomineralised extracellular matrix (ECM). The usefulness of spectroscopic Raman imaging was confirmed in tissue engineering in terms of both the organic and inorganic components considering composite–cells interaction.