bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurology Telemedicine as Virtual Learning: A Student’s Perspective
Authors: Beck Anne-Taylor , Crump William J. , Shah Jignesh J.
Published: August 2020

Small rural regional medical school campuses can be challenged to provide the breadth of learning opportunities required in some specialties.  Here we report our initial experience with a telemedicine stroke consultation service that addressed one of our concerns.  We share an essay from the student perspective as well as those of the regional dean and remote neurology faculty and encourage others to try this technology and report their findings.  The authors have no conflict of interest to report and this study was found to be exempt by the Baptist Health Madisonville Internal Review Board.
Evaluation of a Rural Healthcare System Featuring Medical and Premedical Students: The Essentia Health Summer Research Intern Program
Authors: Benziger Catherine Pastorius , Thiel Ryan , Groth Nicole , Pink Vicki , Doerer Joseph , Dean Katherine
Published: August 2020

Background: Training medical and premedical students in clinical research is challenging with the demands of medical education. Students pursue research opportunities in specialty practice to acquire knowledge and gain experience in the clinical setting. Pairing clinical observation with mentored research informs the value of evidence-based medicine and prepares students for a career in medicine and science. However, programs that offer both research training and clinical observership are rare, particularly in rural areas.  

Hypothesis: Early exposure to sub-specialty practice in rural areas is important to recruit and train the next generation of physicians to serve this population.  

Methods: This report provides a description of the Essentia Health Summer Research Internship Program, a pilot program with the University of Minnesota Medical School aimed to provide mentored clinical research training and clinical observership for medical and premedical students. The program provided an experiential model of clinical patient interaction, problem solving, and access to research that is integrated into clinical experiences as students learn the value of evidence-based medicine.  

Results: Six medical and four premedical students have participated in the internship within the programs first two years. Student-completed weekly journals and surveys reveal enthusiasm for various research and clinical components of the program. Program highlights include the acquisition of research and clinical knowledge through mentorship and research lectures, and observerships throughout the Heart and Vascular Center.  

Conclusion: The program aims to provide underrepresented rural students training in research methodology through mentorship and observership within specialty practice.
Building Novel Research Capacity in a Regional Medical Campus Emergency Medicine Program: 1.0 Origins and Partnerships
Authors: Brown N. Shira , Stobbe Karl , Luterman Maynard , Upadhye Suneel , Henderson Christopher , Chambers Larry W. , Heywood David , Graystone Amber , Ahmed Salim , Davies-Schinkel Corrine , Bell Amanda
Published: August 2020

The Emergency Medicine Researchers of Niagara (EMRoN) program is an evolving research incubator with the Niagara Regional Campus (NRC) of McMaster University’s Michael G DeGroote School of Medicine and Niagara Health (NH) that is becoming a productive research organization aligned with the strategic priorities of its partner organizations (NRC and NH). EMRoN is committed to advancing local community health care standards and sharing best practices with provincial and national peers.  In its first two years of operation EMRoN has achieved success in new structures, processes and outcomes that position it well to be a fulsome research organization for years to come.
Calculation of Consumption and Expenditures for Electricity Energy Costs at Lido Graha Hotel Lhokseumawe City Based on Electrical Power Measurement
Authors: Hasibuan Arnawan , Siregar Widyana Verawaty , Nasution Elvy Sahnur , Ismail Rohana
Published: August 2020

Evaluation of energy utilization and identification become energy saving opportunities, as well as recommendations for increasing efficiency, on energy use and use of energy sources in the context of energy conservation This paper aims to describe the audit of electrical energy in the Lido Graha Lhokseumawe Hotel room, by taking samples in different room types and conducting an electrical energy audit on the use of installed lights and air conditioners. The method used in this study is data collection, interviews, observations and direct measurements on the use of lights and AC (Air Conditioning). The data analysis technique used is to determine the estimated value of electricity consumption and how much it will cost for electricity. From the results of calculations and analysis obtained total electricity consumption needs based on the type of room with various types of loads used 855.62 kWh/days with costs that must be spent per day is Rp. 1,190,574.96, 25,668.6 kWh/month with a monthly cost of Rp. 35,087,608.60. Whereas for a year electricity demand is 308,494.8 kWh/year with a cost of Rp. 421,051,305.24.
Comparative Analysis of Single Exponential Smoothing and Holt's Method for Quality of Hospital Services Forecasting in General Hospital
Authors: Rachmat Rachmat , Suhartono Suhartono
Published: August 2020

The quality health service is one of the basic necessities of any person or customer. To predict the number of goods can be done in a way predicted. The comparison method of Single Exponential Smoothing and Holt's method is used to predict the accuracy of inpatient services will be back for the coming period. Single Exponential Smoothing the forecasting methods used for data stationary or data is relatively stable. Holt's method is used to test for a trend or data that has a tendency to increase or decrease in the long term. The outcome of this study is the Single Exponential Smoothing method is more precise than Holt's method because of the history of hospitalized patients who do not experience an increase or no trend. In addition, the percentage of error (the difference between the actual data with the forecast value) and Mean Absolute Deviation (MAD) to calculate the forecast error obtained from the Single Exponential Smoothing method is smaller compared to Holt's method.
Single Phase Power Factor Improvement Based Instantaneous Power P Q Theorm
Authors: Setiyono Setiyono , Dwinanto Bambang
Published: August 2020

This paper presents how to harmonic disturbance reduce on single phase power system. One of the most popular method is harmonic signal extraction with instantaneous power p q theorm. This algorithm implemented to harmonic cencellation by active power filter circuit be paralled with the non linier load. This filter generates of current compensation that are injected into the grid to improve power quality. This Filter is built by an inverter circuit that consists of a mosfet switch array and capasitor mounted on DC link side. Two types of loads are resitive inductive and resistive capasitive produce of current source wave form that close pure sinusoid. Simulation results show the THD index fell to the level of 2.7% in accordance with IEEE 519 standard rules which states that the harmonics content of the power system may occur below 4%, indicating that the power system can be categorized as having good quality.
The Analysis of Pressure Drop on RL 014 for Condensate Disposal on Geothermal Pipe Line
Authors: Martasari Rial Dwi , Lestari Trias Puji
Published: August 2020

Geothermal energy from the Earth's magma is manufactured in the form of hot steam. On the process of transmission of steam in the Pipe Line, there are various problems such as condensation in the steam. Condensation can cause problems such as pressure drop. The formation of condensate gives a negative impact on production activities both in the pipeline or power plant, thus condensate formed in pipelines should be disposed of via the blow down or steam trap. Due to a large number of steam pipelines in the DW area then to do an analysis of pipelines in order to prioritize the disposal of condensate in the pipe more prone formed condensate. DW Area special analysis was not done against condensation and the number of condensates that are formed so as to indicate the occurrence of condensation done with regular analysis pressure drop in the pipeline. The results of the analysis of the pipeline must first and more frequently carried out disposal of condensate on the RL 014 based on pressure drop highest is line DW 14 a and DW 67, next line DW 18 and 17, and the last is the line 11 and 14 b DW. The condition of the steam trap is also noteworthy if the steam trap leak then it can lower the temperature in the pipe. The drop in temperature in the pipeline will accelerate the condensation, the results of the analysis there is a steam trap leaked is 401.00.17.ST19 and 401.00.05.ST14 . Steam trap leaked that needs to be done to combat the most. The production of steam RL 014 per day was able to donate a 52.52% or about 73.5 MW of the total needs of PLTP (geothermal power plant) 140 MW per day.
The Effect of Thixotropic Additive on the Properties of the G Class Cement
Authors: Maulani Mustamina
Published: August 2020

In oil, gas, and geothermal drilling activities, the casing cementing process is always carried out in order to fulfill its function properly and safely. Therefore, everything that supports these activities must be carefully thought out. Before the actual cementing process is applied in the oil, gas, and geothermal field, laboratory-scale simulation must first be carried out by conducting experiments and testing several formulations of cement, water mixture, and additives to be used. The author chooses thixotropic additives, besides functioning as an accelerator, thixotropic can also strengthen the cement itself. With a number of experiments, an optimal cement slurry composition formulation will be obtained, in the sense that by using as few additives as possible, the requirements of the physical characteristics will meet the required standards for conditions (temperature and pressure) of the formation in the well to be cemented. All cementing activities are expected to run well, smoothly, and on time.
The evolution of views on the possibilities of drug therapy in overcoming acquired resistance not associated with Т790М mutation to anti-EGFR drugs in non-small cell lung cancer
Authors: Karabina E V , Lubchenko L N , Garunov A N
Published: August 2020

Understanding the mechanisms of acquired resistance to tyrosine kinase inhibitors is important for clinicians from the perspective of the possibility of forming more effective options for the second and subsequent treatment of non-small cell lung cancer. The prospects of treatment strategies for patients with non-small cell lung cancer featuring the acquired resistance to tyrosine kinase inhibitors, not associated with the Т790М mutation, are quite vast from a scientific point of view, but in routine clinical practice they are not yet available in full. This article describes the current understanding of the mechanisms of acquired resistance to tyrosine kinase inhibitors not associated with the mutation of T790M, the evolution of views concerning the treatment of non-small cell lung cancer, progressing in the course of the treatment by this group of drugs. The possibilities of effective use of targeted therapy and various combinations of antitumor agents in such cases are also considered. Taking into account the diversity of unresolved issues and directions of further scientific research, we should not forget about the available research results and the ability to use the described options in routine clinical practice in a proper way.
Olaparib in the maintenance treatment of platinum-sensitive relapse of BRCA mutant ovarian cancer in routine clinical practice: first results of observational study in Russian patients
Authors: Artamonova E V , Kovalenko E I , Snegovoy A V , Aksarin A A , Anciferova T A , Belonogov A V , Bilan E V , Bilenko S N , Varvus I M , Gorkovenko E A , Enikeev R F , Ermolaeva A M , Kramskaya L V , Kononenko I B , Pechenyy A P , Safina S Z , Chupriyanova T V , Chuhua G G , Shemyakina A I , Shikina E V
Published: August 2020

Background and aims. There is no data on olaparib efficacy and safety in Russian routine clinical practice. Methods. We analysed the 30 consecutive patients who received maintenance olaparib treatment for platinum-sensitive relapse (PSR) of ovarian or fallopian tube cancer in Russian Cancer Centers. Patients were prescribed olaparib capsules 400 mg twice daily. Radiographic assessments were done every 8 weeks. Patient characteristics. Age median 55 (range 39-68); 26 (86,6%) patients had gBRCA1, 2 (6,6%) patients had sBRCA1, 2 (6,6%) patients had gBRCA2. Number of relapse: median 1 (range 1-10), number of lines of chemotherapy: median 2 (range 2-11). Last regimen of chemotherapy: taxane + platinum (± bevacizumab) 90% (27/30), platinum monotherapy 10% (3/30). Best response to the last chemotherapy complete response 43,3% (13/30), partial response 36,7% (11/30), stable disease 20% (6/30). Results. Median follow-up in 13 CR patients was 12 mos. 1 CR patient progressed after 9 mos of maintenance olaparib. Median follow-up in 11 PR patients was 7 mos. 3 PR patients achieved CR on olaparib. 1 PR patient progressed after 6 mos of olaparib maintenance. Median follow-up in SD patients was 12 mos. 1 SD patient achieved PR on olaparib, there were no progressions. 10 (30%) patients had adverse events (AEs). 1 patient had grade 3 AE and 2 patients had AEs leading to dose reduction. There were no grade 4 AEs. Conclusions. Olaparib is safe and effective maintenance treatment of PSR ovarian cancer in routine clinical settings.
Catamnesis of pediatric thoracic and abdominal cancer survivours
Authors: Mikhailova S N , Zaeva G E , Gavrilenko T F , Sinyagina Yu V , Kazantsev A P
Published: August 2020

Background. Malignancies of thoracic and abdominal localization are the second in pediatric oncopathology, after hemoblastoses. A progress in treatment of this heterogeneous tumors had been achieved by surgery approaches, chemotherapy, supportive care and irradiation role definition in multimodal therapy. Inspite of high survival rate, health condition of pediatric thoracic and abdominal cancer survivours in 5 years and more time in our country are unknown. Aim. To analyze health condition of pediatric thoracic and abdominal cancer survivours and kids, who were born in survivours families. Materials and methods. 324 patients, survived from thoracic and abdominal malignancies were enrolled the study from 1979 to 2015. Patients were subdided into 2 groups: 1st - 126 (38.9%) patients, treated from 1979 to 1996 and 2nd - 198 (61.1%) patients - from 1997 to 2015. Such approach aligned with historical treatment modification - upward 1996 modern anticancer treatment protocols are using and indications for irradiation are limited. Results. By improving therapy of nephroblastoma, decreased number of skeletal disorders from 11.5% in 1st group to 3.9% in 2nd, but increased concomitant renal complications from 5.3% to 21.5% and endocrinopathy from 2.4% to 6.7% in 1st and 2nd groups respectively. In hepar tumours survivours, chronic gastroduodenitis and pancreatoduodenopathy were registrated in 25% and 16% in 1st and 2nd groups respectively. In neuroblastoma survivours, locomotor system pathology (including osteoporosis) was found in 12.1%. Second malignant tumours in period from 8 months to 25 years after end of treatment were in 0,9%, benign - 1,6% of pediatric thoracic and abdominal cancer survivours. Kids, who were born in survivours families, had health condition as their equals in age without oncological family anamnesis. Conclusions. Catamnesis of pediatric thoracic and abdominal cancer survivours can predict possible complications, develop individual rehabilitation and personalized follow up programs. Besides, afterhistory data can help in development of complex treatment approaches for this heterogenous tumours.
Diagnosis of metastatic pulmonary disease: review
Authors: Komarov I G , Belova O S
Published: August 2020

The review presents literature data on the possibilities of modern diagnostic methods in detecting and determining the nature of secondary lung tumors, and also analyzes their main advantages and disadvantages.
Pneumonectomy with carinal resection in patients with non-small cell lung cancer: short and long-term results
Authors: Dadyev I A , Davydov M M , Abdullaev A G , Kulik I O , Ambalova Z A , Akhmedov P I , Anokhin A Yu , Karasheva B M
Published: August 2020

Objective. With to compare short- and long-term treatment outcomes of different carinal resection techniques in patients with non-small cell lung cancer (NSCLC) and carina involvement. Materials and methods. We performed retrospective nonrandomized clinical trial with following groups of patients: patients underwent pneumonectomy with sleeve carinal resection (47 patients); patients underwent pneumonectomy with marginal and wedge carinal resection (18 patients). Statistical analysis was made using Statistic 6.0 program. Case-control analysis of the both groups was performed to evaluate short- and long-term treatment outcomes of different carinal resection techniques in patients with NSCLC and carina involvement. Results. Frequency of non-surgical and surgical complications was 27.7% and 18.5% correspondingly. Postoperative mortality was 8.5% in sleeve carinal resection group and 11.1% in marginal and wedge carinal resection group. Five-year survival rates were 32.6% in sleeve carinal resection group and 11.1% in marginal wedge carinal resection group.
Bendamustine in the treatment of B-cell non-Hodgkin lymphoma
Authors: Babicheva L G , Poddubnaya I V
Published: August 2020

Bendamustine is a uniquely structuredalkylating agent that lacks cross-resistance with other alkylators. This agent has a high degreeof activity against a variety of tumor cell lines.Based on clinical data from randomized phase III trials, bendamustine, with or without rituximab, hasbeen shown to be an appropriate option for first-line treatment or treatment of relapsed/refractory patients with indolent non-Hodgkin’s lymphoma or elderly patients with mantle cell lymphoma. Bendamustine treatment is associated with abetter therapeutic index and offers an improved overall quality of life compared to R-CHOP or R-CVP. It is now often used as achemotherapy backbone for combination with novel drugs including ibrutinib or idelalisib. This article provides a comprehensivesummaryof the clinical data along with practical adviceonhowto optimallymanagepatients with bendamustine therapy, includingdose recommendations, antiemetic prophylaxis, prevention of infusion and skin reactions, as well as prophylaxis of opportunisticinfections. This information might be helpful for clinicians using bendamustine in their daily practice.
The potential use of oncolytic viruses in breast cancer: historical aspects and future prospects (literature review)
Authors: Morozov Dmitriy A , Kolyadina Irina V , Poddubnaya Irina V , Chumakov Petr M , Ilinskaya Galina V , Bokhian Vagan Yu , Sopova Margarita I
Published: August 2020

Viral oncolysis, an approach to cancer therapy that emerged in the XX century and based on the natural ability of viruses to kill (lyse) cells in which it multiplies, has been developed in recent years by identifying viruses or their engineering variants with selective tumor replication. Over the past decades, a number of specific interactions of oncolytic viruses (both RNA and IDNA-containing) with malignant tumor cells have been described, individual candidate viruses and the types of tumors that they lase have been detected. The therapeutic efficacy of oncolytic viruses is achieved through a combination of selective destruction of tumor cells through a direct cytotoxic effect and activation of antitumor immunity; In addition, oncolytic viruses can affect abberant signaling pathways followed by blockade of tumor cell apoptosis, which gives the virus more time to complete its life cycle. A number of oncolytic viruses have shown promising therapeutic efficacy in preclinical studies in breast cancer; thus, the herpes simplex virus has a high selectivity for replication in tumor cells, which contributes to the death and the formation of infiltration of CD8+ and CD4+ T cells around tumor islands. The ability of reoviruses to enhance the expression of PD-L1 protein in cells was found, and the measles virus armed with the BNiP3 proapoptosis gene is more active in the cell lines of triple negative breast cancer. Improved viruses, from the point of view of the effectiveness and selectivity of effects on the tumor, as well as optimized combinations with other "standard" types of systemic therapy, are very promising, especially in patients with developed drug resistance.
Effect of starting dose of regorafenib on overall survival of patients with metastatic colorectal cancer: a systematic review and meta-analysis
Authors: Fedyanin Mikhail Yu , Polyanskaya Elizaveta M , Tryakin Alexey A , Pokataev Ilia A , Tjulandin Sergei A
Published: August 2020

Aim. To conduct a systematic review and meta-analysis of studies on the effect of starting dose of regorafenib on overall survival (OS) of patients with chemorefractory metastatic colorectal cancer. Materials and methods. We searched for research data in the PubMed. The analysis included all publications till 08.20.2019 which compared OS depending on the starting dose of regorafenib (160 mg or less) in the 1st course of therapy. Meta-analysis was conducted using Review Manager Ver. 5.3. Results. Two studies demonstrated decreased OS at starting dose of less than 160 mg (A. Adenis et al., 2016: risk ratio - RR 1.26, 95% confidence interval - CI 1.01-1.56; A. Aljubran et al., 2019: RR 2.25, 95% CI 0.93-5.43). Two studies showed an improvement in OS with a starting dose of less than 160 mg in the 1st course (T. Bekaii-Saab et al., 2018: RR 0.72, 95% CI 0.47-1,11; J. Gotfrit et al., 2017: RR 0.46, 95% CI 0.17-1.22). In two other studies, there was no effect of a starting dose of regorafenib on OS (K. Yamaguchi et al., 2019: RR 0.95, 95% CI 0.82-1.1; G. Argiles et al., 2019: RR 0,86, 95% CI 0.65-1.13). The meta-analysis did not reveal the effect of starting dose of the drug on OS: RR 0.97, 95% CI 0.78-1.21; p=0.79; I2=64. Conclusions. Reducing the starting dose of regorafenib in the 1st course does not decrease OS and can be recommended for routine clinical practice.
Modern ultrasound technologies in monitoring the effectiveness of chemotherapy for cervical cancer
Authors: Musaeva Zalina R-B , Chekalova Marina A , Mesheryakov Andrei A
Published: August 2020

Cervical cancer remains one of the most important social and medical problems worldwide due to the increase in morbidity and mortality. Improvement of existing and development of new options for diagnosis and treatment of common stages of cervical cancer is an urgent problem of modern Oncology. In accordance with the standards of treatment for advanced cervical cancer, drug, radiation therapy and surgical treatment in various modifications are used. Neoadjuvant chemotherapy can reduce the volume of tumors, which helps to achieve optimal resectability of the tumors, increases the ablasticity of the operation. In addition, it improves survival. An accurate assessment of the effectiveness of treatment is one of the important factors in the overall treatment. Complex ultrasound diagnostics is the most affordable and common imaging method, possessing a number of important technologies, allowing you to get the most objectively visualized tumors, uterus, prevalence, blood flow features and to receive timely information about tumor regression. In connection with the introduction of new technologies, a significant expansion of the capabilities of ultrasound diagnostics in oncology as a whole is observed today. The most promising of them are ultrasound elastography and contrast-enhanced ultrasound. The review is devoted to the possibilities of these methods in assessing the effectiveness of neoadjuvant chemotherapy.
Osimertinib for the first-line treatment of EGFR-positive non-small cell lung cancer
Authors: Reutova Elena V , Laktionov Konstantin P , Iudin Denis I , Neliubina Lidiia A , Gorokhova Galina K , Egorova Angelina V
Published: August 2020

In the past century, lung cancer has become one of the most prevalent malignant neoplasms. The prognosis for patients with metastatic and locally advanced non-small cell lung cancer (NSCLC) was extremely pessimistic. The overall survival on standard platinum-based chemotherapy did not exceed 10 months. The treatment tactics choice, namely choice of specific chemotherapeutic regimen, was empirical. The situation has changed dramatically with the study of molecular-genetic disorders that contribute to a tumor development and targeted therapy availability. Until recently, the main approach to the treatment of patients with NSCLC with activating mutations was the use of first-generation tyrosine kinase inhibitors (TKI), then, in the case of disease progression, the administration of next generations drugs or chemotherapy. However, this trend has been changing lately, new generation of targeted drugs have a significant advantage in time till progression, better intracranial control, a more favorable safety profile, that establish them as first-line treatment. Recent data confirms also an improvement of overall survival. This article discusses the situation in EGFR-postive NSCLC.
The role of a multidisciplinary approach in the treatment of hepatocellular carcinoma
Authors: Kit Oleg I. , Vladimirova Liubov Iu. , Storozhakova Anna E. , Snezhko Tatiana A. , Kalabanova Elena A. , Samaneva Natalia Iu. , Svetitskaia Iana V. , Kabanov Sergei N.
Published: August 2020

Aim. Evaluation of treatment options and efficacy in patients with hepatocellular carcinoma based on data from the FSBI Rostov Cancer Research Institute using a multidisciplinary approach to the problem.
Materials and methods. 124 cases of hepatocellular carcinoma were analyzed. In 79.8% of patients (average age of 61.4 years) the disease was diagnosed at advanced stages (IIIIV). Antibodies to viral hepatitis B were detected in 18 (14.5%) patients, and antibodies to viral hepatitis C in 35 (28.2%) patients. Liver cirrhosis occurred in 38 (30.6%) cases, and ChildPugh class A in 20 (16.1%) cases. In the FSBI RCRI, a multidisciplinary approach has been introduced into clinical practice; decision on treatment tactics is made with a close cooperation of several specialists. The use of special treatment methods was available in 67 (54%) patients. 32 patients with Barcelona Clinic Liver Cancer (BCLC) stage A (early) or stage B (intermediate), had surgical treatment or hepatic arterial chemoembolization (HACE) with lipiodol or microspheres using various cytostatics (18 and 14 patients, respectively). 35 patients with advanced stage C were given a systemic therapy with various cytostatics (gemcitabine, oxaliplatin, doxorubicin) or targeted therapy with sorafenib. The treatment efficacy was assessed according to mRECIST.
Results. The best median overall survival (OS) up to 21 months was in the group of patients (n=18) who underwent volume resection surgery. In this group, sorafenib was prescribed to 2 patients after surgery. When performing HACE, the median OS was 14.2 months. In 6 patients, HACE was performed 2 or more times. Among the 14 patients who had HACE, sorafenib was prescribed in 8 cases, and the median OS in this group was 16.3 months. 20 patients were given targeted therapy with sorafenib. Following 3 months of taking the drug, 16 patients achieved stabilization of the disease according to the mRECIST, in 1 patient a partial response, in 3 patients disease progression. Median OS was 9.1 months; progression-free survival among patients treated with sorafenib was 5.4 months.
Conclusions. The use of a multidisciplinary approach in clinical practice makes it possible to choose the optimal treatment option for hepatocellular carcinoma and contributes to the improvement in OS. The combination of local treatment methods (surgical treatment, HACE) with effective drug therapy is the most optimal approach to treating patients with advanced stages of hepatocellular carcinoma.
Sip feeding as a type of nutritional and metabolic support in clinical medicine
Authors: Shestopalov Aleksandr E. , Dmitriev Aleksandr V.
Published: August 2020

The article provides an analytical review of the use of oral enteral nutrition (OEN, or sip feeding) as an adjuvant therapy and nutritional and metabolic support in various diseases and pathological conditions. Liquid and powdery sip feeds are currently becoming increasingly widespread due to their physiological nature and effectiveness in maintaining a nutritional status and eliminating nutritional deficiency in patients from different fields of medicine: oncology, musculoskeletal disorders, cardiovascular and pulmonary diseases (chronic obstructive pulmonary disease) and others. These sip mixtures contain proteins, fats, carbohydrates (macronutrients), omega-3 polyunsaturated fatty acids, as well as vitamins and minerals. Sip feeding is a supplement to a regular diet and is given between meals. The most prevalent sip feeding scheme is taking liquid forms of sip feeds in volumes of 200300 ml 23 times a day. Regimes which combine a regular diet and OEN should provide target indicators of energy and protein consumption: 2530 kcal/kg per day and 1.41.8 g of protein per 1 kg of body weight per day. In extremely severe cases, protein intake may be increased. Calorie ratio for individual nutrients in total energy consumption: proteins/fats/carbohydrates 20/30/50%. Sip feeding improves clinical and financial outcomes in inpatient and outpatient practice: shortens the time of staying in the clinic; reduces the number of infectious and non-infectious complications, the rate of repeated hospitalizations; treatment costs; improves the quality of life. OEN is recommended by the European Society for Clinical Nutrition and Metabolism guidelines and by many national guidelines on enteral nutritional support.
Possibilities of epigenetic therapy of acute myeloid leukemias in children
Authors: Seregin Georgii Z. , Lifshits Anna V. , Аleskerova Gunel А. , Valiev Timur T.
Published: August 2020

The results of the treatment of acute myeloid leukemia (AML) in pediatric patients remain poor. The modern programs of treatment allow achieving long-term survival in only 6570% of patients and the event-free survival rates are lower and make up approximately 55%. The development of protocols for high-intensity therapy, which are based on the block principle, followed by long-term maintenance therapy has led to the significant progress in the treatment of AML. As supportive care has improved, it became possible to escalate the doses of chemotherapy, which contributed to the increase of the treatment effectiveness. So far, doses and drugs administration regimens have approached the tolerated level, which necessitates the research into new therapeutic targets. An investifation of the epigenetic processes underlying leukemogenesis made it possible to identify those targets DNA methylation and histone deacetylation. This review presents the results of the use of epigenetic drugs in the treatment of AML in children. The possibilities of including epigenetic agents in standard polychemotherapy protocols are presented.
Modern immunological criteria for a stratification of risk groups for precursor B cell acute lymphoblastic leukemia in children
Authors: Shervashidze Meri A. , Valiev Timur T. , Batmanova Natalia A. , Tupitsyn Nikolai N. , Serebryakova Irina N.
Published: August 2020

Background. Modern therapy programs allow achieving high survival rates in children with acute lymphoblastic leukemia (ALL). However, there is a group of patients in whom a relapse occurs, which makes it necessary to search for optimal tools for monitoring remission and the earliest detection of ALL relapse. According to clinical and immunological studies, assessment of minimal residual disease (MRD) levels is one of the leading criteria for response to treatment and can be the basis for risk-stratified therapy.
Aim. Assessment of MRD levels on the 15th day of induction as the main parameter for stratification of patients into prognostic risk groups and the impact of MOB levels on patient survival.
Materials and methods. The study included 117 children with a newly diagnosed precursor B-cell ALL. All patients were given an induction course according to the BFM ALL IC 2009 protocol.
MRD levels were determined by flow cytometry.
Results. Given the MRD based stratification, a truly standard risk group was identified, the survival rate of which reached 100%.
Conclusions. The use of MRD as the main tool for the risk of adapted therapy made it possible to improve survival in patients of the standard risk group, as well as to optimize therapy for high and medium risk groups in the future.
SDH-deficient gastrointestinal stromal tumors: paradoxical effect of imatinib
Authors: Filonenko Daria A. , Meshcheryakov Andrey A. , Arkhiri Petr P. , Nikulin Maxim P. , Kolobanova Evgeniia S.
Published: August 2020

Succinate dehydrogenase deficient gastrointestinal stromal tumors (dSDH GIST) is a unique group of GISTs with an energy metabolism defect as the key oncogenic mechanism without mutations in the proto-oncogene receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor a (PDGFRA). SDH-deficiency is a result of mutations in SDHA, SDHB, SDHC, SDHD. There are three variants of dSDH GIST: sporadic dSDH GIST, Carney triad or Carney-Stratakis syndrome. dSDH GISTs are characterized by young age, female prevalence, gastric location, multiple tumors, lymph node metastases, indolent behavior and poorly response to imatinib. Despite the literature data, we report the response to imatinib in patient with dSDH GIST. 21 year old female patient presented with incomplete Carney triad (multiply gastric GIST with liver and peritoneal metastases, left lung chondroma). The patient received imatinib with clinical response in a month and radiological response in three months-cystic transformation of primary gastric tumor and liver metastases. The duration of response was 8 months.
Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
Authors: Lyubimova Nina V. , Beishembaev Almaz M. , Timofeev Yurii S. , Zhordania Kirill I. , Kushlinskii Nikolai E.
Published: August 2020

Introduction. Granulosa cell tumors of ovary (GCTO) rare type of malignant ovarian neoplasms formed from granulosa cells of the follicles capable to produce biologically active substances, including inhibin B. The purpose of this study is evaluation of clinical significance of inhibin B analysis in blood serum of patients with adult type of GCTO primary disease, relapse and during remission after treatment.
Materials and methods. The study included 134 patients with GCTO, 15 patients with benign ovarian tumors and 82 healthy women. Inhibin B was determined in blood serum with standard enzyme-linked immunosorbent assay Inhibin B Gen II ELISA (Beckman Coulter, USA) in the microplate format.
Results. The analysis data indicates a high sensitivity of inhibin B in the diagnosis of primary GCTO (92.3%) and in relapse (92.7%) with a specificity 100%. An increase of inhibin B before the clinical manifestation of relapse (for 212 months) confirms its significance as an effective biochemical marker for GCTO monitoring.
Conclusion. Inhibin B can be used as effective biochemical marker of primary and GCTO and its relapses.
Hodgkin's lymphoma
Authors: Demina E. A. , Tumyan G. S. , Moiseeva T. N. , Mikhailova N. B. , Myakova N. V. , Rumyantsev A. G. , Maschan A. A. , Kaplanov K. D. , Shmakov R. G. , Falaleeva N. A. , Ptushkin V. V. , Osmanov E. A. , Poddubnaya I. V. , Baikov V. V. , Kovrigina A. M. , Konovalov D. M. , Trofimova O. P. , Sotnikov V. M. , Ilin N. V. , Vinogradova Yu. N. , Nechesnyuk A. V. , Parkhomenko R. A. , Stefanov D. N. , Nevolsky A. A. , Ivanov S. A. , Khaylova Zh. V.
Published: August 2020

Clinical recommendations.
High-dose chemotherapy following autologous hematopoietic stem cell transplantation for multiple myeloma in the real world setting. Single-center experience
Authors: Mochkin Nikita E. , Sarzhevskiy Vladislav O. , Dubinina Julia N. , Smirnova Elena G. , Fedorenko Denis A. , Bannikova Anna E. , Kolesnikova Dina S. , Bogatyrev Vladimir S. , Samoylova Anastasia A. , Faddeev Nikolay M. , Melnichenko Vladimir Ya.
Published: August 2020

Aim. To assess the long-term results of high-dose chemotherapy following autologous hematopoietic stem cell transplantation (autoHSCT) for multiple myeloma (MM) in the real setting and influence of different factors on the results.
Materials and methods. From 2006 till 2018 in Pirogovs Center were performed 205 autoHSCT for patients with MM, aged between 3172 years (median 55). 55 (26.8%) autoHSCT were tandem. The study population consisted of 45% men and 55% women. Median follow up was 75 months. For the majority of patients autoHSCT was performed after achieving at least partial response according to the IMWG criteria. For less than 9% patients, autoHSCT was done for chemo refractory disease as a salvage therapy. Most of the patients 179 (87.4%) were treated using melphalan-based conditioning regimens (140 or 200 mg/m2). Initial staging according to ISS was done for less than 30% and to R-ISS less than 5% patients. No transplant-related mortality till D + 100 was registered. 186 patients were included in the final analysis.
Results. The 5-year OS and PFS were 73% and 34%, respectively, that corresponds with international data. For patients, younger than 60, 5-year OS was 82%; for patients older than 60, it was 49% (p0.05). For tandem autoHSCT, 5-year PFS was 44%; for single autoHSCT 26% (p0.05). 5-year PFS after autoHSCT was significantly higher in patients with complete and stringent complete response after autoHSCT (44%) in comparison with the group with partial and very good partial response (77%). Sex, response before and after autoHSCT, immunomodulatory drugs in induction, number of prior lines of induction therapy, conditioning regimen and maintenance therapy had no influence on OS. PFS had the same tendencies, except tumor response after autoHSCT.
Conclusion. In a real setting, we recommend tandem autoHSCT for all eligible patients with chemosensitive disease, despite the depth of response and induction therapy. Patients younger than 60 and patients with complete of greater response after autoHSCT, benefit from the autoHSCT most. Implementation of total cytogenetic testing according to the R-ISS is of a great value for further development of autoHSCT for MM in Russia.
Therapy of Hodgkin lymphoma in Russia during the COVID-19 pandemic
Authors: Poddubnaya Irina V. , Baryakh Elena A. , Vorobyev Vladimir I. , Demina E. A. , Zhukov Nikolay V. , Kaplanov K. D. , Konstantinova T. S. , Motorin Dmitry V. , Ptushkin V. V. , Sarzhevsky Vladislav O. , Tumyan G. S.
Published: August 2020

Relevance. COVID-19 pandemic currently has a significant negative impact on the treatment of patients with oncological pathology, including patients with classic Hodgkin lymphoma. Generalized data on publications on the impact of concomitant pathology on the severity of infection show a significant increase in the risk of death from infection in male patients, aged 60 years, with the presence of 3 concomitant diseases, among which particularly negative role is played by diseases of the cardiovascular system, diabetes, oncology, chronic lung disease, immunodeficiency conditions. Particularly dangerous is the development of COVID-19 infection in an interval of less than 14 days from the course of antitumor therapy. At the same time, patients with Hodgkin lymphoma require immediate treatment, often associated with toxic, immunosuppressive therapy, frequent visits to the clinic, hospitalizations. International communities have not yet developed clear guidelines for the management of patients with Hodgkins lymphoma. Taking into account the understanding that the circulation of coronoviral infection will continue in the population, the Advisory board on the Problems of Hodgkin Lymphoma Therapy in the COVID-19 Pandemic is highly relevant.
Aim. To change and adapt current treatment approaches in the current epidemiological environment.
Results. The main directions of the impact of the COVID-19 pandemic on the treatment of patients with cancer pathology, including patients with classical Hodgkin lymphoma, were determined, key problems in the treatment of LC during the COVID-19 pandemic were identified, and measures aimed at reducing the risk for patients were developed. Existing approaches to first-line, relapse/refracturing cHL therapy, including salvage therapy, and auto/allo SCT during the COVID-19 pandemic, have been adapted.
Clinical case of long-term use of durvalumab in the treatment of advanced small-cell lung cancer
Authors: Statsenko Galina B. , Kurakin Vyacheslav I. , Plokhotenko Irina V.
Published: August 2020

Over the last few decades there was a little progress in the treatment of small cell lung cancer (SCLC). But now the approaches are changing with immune checkpoint inhibitors coming into clinical practice. Using a combination of immunotherapy with the standard chemotherapy in the first line of extensive stage small cell lung cancer (ES-SCLC) results in significant overall survival improvement, for the first time the median survival in these patients exceeded one year. Here we present a clinical case of ES-SCLC patient treated with durvalumab, a monoclonal antibody against PD-L1, in combination with etoposide and carboplatin in the CASPIAN clinical trial. In the CASPIAN trial more than 20% of patients treated with durvalumab stay alive more than two years. In the presented case we also reported durable control of the disease, the patient continued to receive durvalumab of more than two years with acceptable tolerability.
XÁC ĐỊNH ĐỘC LỰC, ĐỘ MẪN CẢM KHÁNG SINH CỦA VI KHUẨN SALMONELLA SPP. PHÂN LẬP TỪ BÊ GIAI ĐOẠN BÚ SỮA BỊ TIÊU CHẢY TẠI HUYỆN ĐỨC TRỌNG TỈNH LÂM ĐỒNG
Authors: Hòa Nguyễn Xuân , Tuấn Phạm Đăng , Hoàn Lê Trần , Việt Lê Quốc , Phước Lê Văn , Danh Nguyễn Đức , Hải Phan Vũ
Published: August 2020

Tóm tắt. Vi khuẩn Salmonella có khả năng sản sinh nội độc tố mạnh, là nguyên nhân viêm ruột và gây nên bệnh tiêu chảy của bò. Nghiên cứu phân lập 74 mẫu phân bê tiêu chảy tại huyện Đức Trọng, tỉnh Lâm Đồng đã xác định tỷ lệ nhiễm vi khuẩn Salmonella của bê là 51,35%. Kết quả PCR xác định gene độc tố của vi khuẩn Salmonella cho thấy có 12/36 chủng vi khuẩn có gene mã hóa độc tố, trong đó có 8 chủng (21,05 %) dương tính với gen quy định độc tố đường ruột Stn, và 8 chủng (21,05%) vi khuẩn mang yếu tố xâm nhập Inv A. Đặc biệt có 4 chủng vi khuẩn đồng thời mang yếu tố xâm nhập Inv A và độc tố đường ruột Stn (chiếm 10,53%). 8/12 chủng vi khuẩn Salmonella phân lập được từ phân bê tiêu chảy đều có độc lực mạnh - giết chết toàn bộ chuột thí nghiệm trong 24-36 giờ. Vi khuẩn Salmonella mẫn cảm cao (87,5 - 100%) với kháng sinh Gentamycin và Enrofloxacin, mẫn cảm trung bình với Amoxicillin, Doxycycline và Ceftiofur, trong khi đó kháng hoàn toàn kháng sinh Oxytetracyclin.
THỰC TRẠNG TIẾP CẬN THÔNG TIN ĐẤT ĐAI CỦA NGƯỜI DÂN TẠI THỊ TRẤN ÁI TỬ, HUYỆN TRIỆU PHONG, TỈNH QUẢNG TRỊ
Authors: Qúy Lê Ngọc Phương , Tân Nguyễn Quang , Nhật Nguyễn Tiến , Đức Lê Anh
Published: August 2020

Tiếp cận thông tin về đất đai đóng vai trò quan trọng trong quản lý tài nguyên đất, đặc biệt trong bối cảnh ngày càng có nhiều nhu cầu cạnh tranh về tài nguyên đất do quá trình đô thị hóa nhanh chóng hiện nay. Nghiên cứu này được thực hiện tại thị trấn Ái Tử, huyện Triệu Phong, tỉnh Quảng Trị nhằm mục đích tìm hiểu thực trạng tiếp cận thông tin đất đai của người dân, từ đó có những đề xuất giải pháp hướng tới quản lý đất đai hiệu qủa. Nghiên cứu kết hợp phương pháp quan sát trực tiếp, thu thập số liệu thứ cấp và phỏng vấn 45 hộ đã làm thủ tục hành chính về chuyển nhượng và tặng cho đất đai và phỏng vấn sâu cán bộ chuyên môn tại địa bàn nghiên cứu. Có ba kết quả chính được phát hiện trong nghiên cứu bao gồm, thứ nhất, người dân tiếp cận các thông tin về đất đai thông qua hai kênh chính thức là: thông tin tại bảng niêm yết tại trụ sở thị trấn và thông tin trực tuyến từ cổng thông tin điện tử của Huyện Triệu Phong, tỉnh Quảng Trị. Thứ hai, 66,7% số hộ chưa từng đọc thông tin tại bảng niêm yết và 73,3% chưa từng biết đến cổng thông tin điện tử đối với thủ tục hành chính. Nghiên cứu cũng chỉ ra một số vấn đề khó khăn trong tiếp cận thông tin về đất đai của nông hộ, từ đó đưa ra các khuyến nghị cho cả chính quyền và người dân địa phương.
NGHIÊN CỨU TUYỂN CHỌN GIỐNG NGÔ NẾP TẠI THỪA THIÊN HUẾ
Authors: Sen Trịnh Thị , Nhi Phan Thị Phương
Published: August 2020

Tóm tắt: Nghiên cứu được tiến hành trên 14 giống ngô nếp, nhằm xác định giống có khả năng sinh trưởng phát triển tốt, cho năng suất cao và phẩm chất khá làm nguồn vật liệu cho việc lai tạo giống ngô nếp mới. Thí nghiệm bố trí theo phương pháp tuần tự không nhắc lại, mỗi giống là một công thức, tiến hành trong vụ Đông xuân 2016-2017 và Hè thu 2017, tại vườn thực nghiệm khoa Nông học, trường Đại học Nông Lâm Huế, Đại học Huế. Các chỉ tiêu nghiên cứu thực hiện theo Quy chuẩn về khảo nghiệm giá trị canh tác và giá trị sử dụng của giống ngô. Kết quả nghiên cứu cho thấy các giống ngô nếp có khả năng sinh trưởng phát triển tốt, đạt năng suất và phẩm chất khá lần lượt qua 2 vụ trồng là Tuyên Hóa - Quảng Bình (86,0; 74,3 tạ/ha), Quảng Trạch - Quảng Bình (65,1; 55,8 tạ/ha), Cam Lộ - Quảng Trị (62,5; 58,1 tạ/ha), Triệu Phong - Quảng Trị (75,3; 56,1 tạ/ha) và Bình Sơn - Quảng Ngãi (51,3; 48,9 tạ/ha). Chúng tôi đã tuyển chọn 05 giống ngô nếp này làm nguyên liệu cho những nghiên cứu tiếp theo.Từ khóa: Chất lượng, giống ngô địa phương, năng suất, ngô nếp.
Representasi Budaya Suku Tidore dalam Trailer Suanggi
Authors: Masri Yul Isti
Published: August 2020

Penelitian ini bertujuan untuk mengetahui budaya suku Tidore melalui trailer Suanggi, dan objek dari penelitian ini adalah trailer Suanggi. Trailer Suanggi mempunyai maksud serta pesan tentang kebudayaan, adanya nilai adat istiadat serta kepercayaan maupun keyakinan yang sudah dikemas sedemikian rupa dalam trailer tersebut. Kebudayaan sendiri hingga saat ini sudah melekat pada masyarakat Indonesia terlebih lagi pada masyarakat Tidore sendiri dengan kebudayaan yang ada. Trailer dari film Suanggi merupakan sebuah cerita yang berasal dari Tidore. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Dalam penelitian ini teori yang digunakan adalah teori representasi. Teknik pengumpulan data yang digunakan adalah teknik observasi, wawancara, mengumpulkan data dari internet serta teknik per-adegan. Kemudian objek dari penelitian ini adalah Trailer dari film Suanggi dengan mengambil empat adegan dari trailer tersebut, empat adegan tersebut adalah adegan penelitian di tanah Tidore, adegan tidak direstui oleh orang tua, adegan munculnya Suanggi dan adegan Suanggi yang meresahkan masyarakat. Berdasarkan hasil dari penelitian empat adegan yang didapat dari trailer Suanggi sendiri, dimana budaya Suku Tidore yang direpresentasikan pada trailer film Suanggi seperti: pakaian adat Tidore, Sesajian dan manusia yang bersekutu dengan Suanggi atau yang dipercaya sebagai makhluk yang sering didatangi oleh manusia jika suasana hati seperti sedang dendam atau mempunyai rasa iri hati. Sedangkan untuk nilai kebudayaan yang direpresentasikan suku Tidore dalam trailer Suanggi yang pertama: adanya nilai kepercayaan, dimana kepercayaan terhadap animisme masih diyakini hingga sekarang oleh masyarakat Tidore. Yang kedua: nilai adat istiadat, seperti meminta izin terlebih dahulu kepada petuah jika hendak melakukan sesuatu atau sekedar hanya datang berkunjung.