bluuebunny/crossref_metadata_2025 huggingface dataset:
Action of the 4-Nitro-2-phenoximethanesulphonanilide (Nimesulide) on neutrophil chemotaxis and superoxide production
Authors: Mello Susana Beatriz Veríssimo de , Laurindo leda Maria Magalhães , Cossermelli Wilson
Published: June 2009

4-nitro-2-phenoximethanesulphonanilide (nimesulide) is a nonsteroidal anti-inflammatory agent that has been employed in the treatment of inflammatory diseases because of its specific actions on the inflammatory response mechanisms caused by injury. The objectives of this paper were to determine the action of this agent on two notable neutrophil functions, chemotaxis and production of the superoxide anion. These two functions were studied after the neutrophils were pre-incubated with three different concentrations of 4-nitro-2-phenoximethanesulphonanilide (0.1; 0.3 and 0.5 mN). The results obtained herein demonstrated that 4-nitro-2-phenoximethanesulphonanilide-exposed peripheral blood neutrophils from healthy subjects produced significantly less superoxide when challenged by phorbol-mirystate acetate (PMA at 50 ng/ml) or formy-methionil-leucyl-phenilalanine (FMLP 10 -7 M) and opsonizided zymozan (1 mg/ml). Additionally, the agent was equally effective in reducing the PMN chemotoaxis when challenged by C5a factor (2% zimozan activated solution), FMLP 10 -9 M and leukotrien (3. 10 -7 M). The results obtained suggest that in addition to its interference in the metabolism of the aracdonic acid, the 4-nitro-2 phenoximethanesulphonanilide may interfere in a more direct fashion with the neutrophil function. This specific action may contribute to its anti-inflammatory activity.
Assessment of functional capacity during gait using a reciprocal propulsion orthosis (ARGO): a comparative study with a conventional mechanical orthosis
Authors: Muszkat Rachel , Yazbek Jr. Paulo , Arango Claudia T. , Moreira Maria Cecilia , Trombetta lvani C. , Battistella Linamara Rizzo
Published: June 2009

One subject (male, 24 years) with an incomplete motor and sensitive SCI, neurological level C6-C7 was submitted to a comparative study during gait using an advanced reciprocaiting gait othosis (ARGO) and a conventional mechanical orthosis (CMO) and respiratory and metabolic variables were compared at peak effort and in the second minute of recovery. We found that the ARGO, as with the CMO, not garantee gait independence but the ARGO does enable a more functional gait pattern with a more efficient ventilation . The ratio of CO2/O2 showed that ARGO enable aerobic conditions of work and the energy expenditure using is significantly lower than CMO.
Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement
Authors: Gebrim Luiz Henrique , Lima Geraldo Rodrigues de , Gianotti Filho Osvaldo , Barreto Elci , Baracat Fausto F. , Grabert Hartmut H.
Published: June 2009

The biological behavior of breast cancer supports the impression that it is often a systemic disease which can recur many years after the treatment of the local lesion. Since 35% of patients without axillary nodal metastasis will have recurrence of the disease after mastectomy, prognostic indicators are necessary to identify the high-risk patients to allow a more rational adjuvant therapy. We studied the prognostic value of fatty tissue invasion, perineural involvement and lymphatic and venous peritumoral embolization in T2NOMO primary breast carcinomas. Fifty-three patients were studied after initial treatment (only Halsted mastectomy). They were divided into two groups: A (control), with 25 patients with 15 years of survival without clinical and laboratory evidence of metastasis, and group B, with 28 patients who developed metastasis after initial treatment. The results were analysed by the chi-square test (p<0.05). The fatty tissue invasion was identified in 56.0% and 78.5% in the A and B groups respectively, while venous embolization was only detected in 8.0% of the group A tumors and in 10.7% of those in group B. Neither showed significant variation when analyzed according to the chi-square test. Lymphatic embolization and perineural involvement were found respectively in 36.0% and 40.0% in the group A tumors and in 67.8% and 71.4% of those in group B, exhibiting a significant statistical variation. When analysing the histopathological characteristics in the pre- and post-menopausal patients, the chi-square test disclosed that lymphatic embolization and perineural involvement had a significantly higher incidence only in pre-menopausal patients in group B.
Intermittent negative pressure ventilation may increase urine flow in normal subjects
Authors: Dias Ricardo Marques , Stabile Carlos , Dotto Pedro , Jardim José Roberto
Published: June 2009

In order to analyze the effect of intermittent negative pressure ventilation (NPV) on renal function, we studied 20 healthy male volunteers (mean age 29±4.1 years). NPV was performed with an "Emerson Chest Respirator Pump", adjusted to a breathing frequency of 10 respirations per minute, with inspiratory time/total respiratory time ratio of 0.4 and negative pressure of 25 cmH2O. The experimental protocol was carried out in two phases of two hours each - spontaneous breathing and NPV breathing. At the end of each phase, urine volume of the whole period was collected as well as venous blood sample for biochemical determinations. During NPV there was significant increase (P<0.05) in urine flow rate (1.43±0.81 to 2.76±1.95 ml/min) as well as in natriuresis (258±201 to 389±175 mcEq/min), kaliuresis (61±45 to 98±49 mcEq/min), fractional sodium excretion (1.38±0.88 to 1.96±0.98%), osmolar clearance (3.13±1.82 to 4.32±1.24 ml/min) and pH (7.37± 0.04 to 7.41±0.07) with unchanged creatinine and free water clearances. We concluded that NPV increases urine flow rate, kaliuresis and natriuresis but the data we have do not allow us to explain the mechanisms underlying such a phenomenon.
Supraceliac clamping in the surgical treatment of abdominal aortic aneurysm: an experimental study in dogs
Authors: Piccinato Carlos Eli , Gomes Uilho Antonio , Piccinato Maria Aparecida Neves Cardoso , Souza Maria Eliza Jordani , Franco Clarice Fleury Fina , Cherri Jesualdo
Published: June 2009

Previous reports have suggested the use of supraceliac aortic clamping in the surgical treatment of abdominal aortic aneurysm of difficult approach. The objective of the present report was to study the hepatic and renal metabolic changes of three groups of dogs submitted to temporary clamping (30 minutes) of the abdominal aorta at three different levels: below the renal arteries, infrarenal group (8 dogs); above the renal arteries, uprarenal group (9 dogs); above the celiac artery, supraceliac group (9 dogs). Blood bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen, and creatinine levels were measured before clamping and 5 minutes and 24 hours after reperfusion of the aorta. Bilirubin levels remained unchanged 5 minutes and 24 hours after reperfusion in all three groups. Alkaline phosphatase levels were significantly increased in all three groups 24 hours after reperfusion. ALT levels increased significantly in the supraceliac group and AST levels increased significantly in the infrarenal and supraceliac groups 24 hours after reperfusion of the aorta. However, despite these significant increases after reperfusion, the levels of these hepatic enzymes were still within the normal range for dogs. Urea nitrogen and creatinine levels showed that renal function did not change in any of the three groups. We conclude that supraceliac, infrarenal or suprarenal aortic clamping for 30 minutes do not promote any important changes in the hepatic or renal function of dogs.
Parenteral injection of organophosphate insecticide: apropos of two cases
Authors: Nishioka Sérgio de Andrade
Published: June 2009

Two cases of parenteral injection of organophosphate insecticide are reported. A 20-year-old man injected himself malathion intramuscularly, The developed necrosis in the injection set and abscess formation, and developed a severe poisoning reaction of late onset that was fully manifested 60 hours after the injection. A 22-year-old girl injected herself subcutaneously a small amount of fenitrothion and had severe swelling of the affected limb and a sterile abscess. In cases of parenteral injection of organophosphates, attention must be paid to the possibility of late onset of the clinical manifestations of the poisoning, and to the fact that usual measures to reduce exposure to the organophosphate, such as induction of vomiting, gastric lavage and use of activated charcoal are probably ineffective. Local complications at the site of the injection, like necrosis and abscesses are also expected findings.
Rhabdomyosarcoma mimicking Wilms' tumor
Authors: Bittencourt Achiléa Lisboa , Mendonça Núbia , Schmitt Fernando
Published: June 2009

A case of a 6 year old child, with a pleomorphic rhabdomyosarcoma involving simultaneously the leg muscles and the kidney is reported. The renal tumor distorted the pyelocalycial system and Wilms' tumor was the clinical diagnosis. The authors discuss on the possible primary site of the tumor.
Chronotopic and blood pressure response to oral glucose load in chagas' disease
Authors: Guariento Maria Elena , Olga Elza , Muscelli Ana , Gontijo José Antonio Rocha
Published: June 2009

Cardiac chronotropic and pressor responses after an oral load of glucose were assessed in sixteen Chagasic subjects and 28 controls by means of blood pressure and pulse rate measurements. Cardiovascular response was correlated with serum insulin and glucose levels. The experiment identified a subgroup of Chagasic subjects (n=8) with a hypoinsulinemic behavior presenting less chronotropic and pressor responses than controls. This may indicate a lower insulin activity and/or an early Autonomic Nervous System dysfunction in this subgroup.
Acute efects of the Paulinia cupana, "Guaraná" on the cognition of normal volunteers
Authors: Galduróz José Carlos Fernandes , Carlini Elisaldo de Araújo
Published: June 2009

The authors studied the acute effects of "Guaraná", when compared to caffeine and placebo, (double blind study) on cognition, anxiety and sleep in 30 normal volunteers. Although results were negative it cannot be concluded that "Guaraná" is harmless. Other studies shall be undertaken, administering "Guaraná" on a long term basis, as popularly proclaimed.
Colonic (splenic flexure) necrosis due to thrombosis of the middle colic artery following blunt abdominal trauma
Authors: Coimbra Raul , Aguiar José Ribeiro , Rasslan Samir , Ressurreição Silvio Pires
Published: June 2009

We report an unusual case of a 28-year-old man who developed a colonic necrosis due to thrombosis of the middle colic artery 18 hours following blunt abdominal trauma. Although rare, this condition can occur in those patients whom non surgical treatment was initially performed.
Aspergillary bronchopneumonia: an unusual cause of atelectasis and asphyxia in a leukemic patient
Authors: Velloso Elvira Deolinda Rodrigues Pereira , Martinez Gracia Aparecida , Dorlhiac-Llacer Pedro Enrique , Chamone Dalton Alencar Fischer
Published: June 2009

A 22-year-old man in his first relapse of T-acute lymphoblastic leukemia developed fever and a pulmonary infiltrate after 23 days of granulocytopenia. Although having been under amphotericin B for 10 days, productive purulent cough ensued, with right lobe atelectasis and acute ventilatory failure that resolved after the elimination of a thick gelatinous bronchial plug. Sputum cultures yielded Candida Albicans and Staphylococcus epidermidis, and microscopic examination of the sputum plug disclosed Aspergillus hyphae. The patient died 9 days after, of a disseminated Aspergillus infection, confirmed by necropsy.
Nucleolar Organizer Regions (NORs)
Authors: Altemani Albina Messias de Almeida Milani
Published: June 2009

Counts of nucleolar regions (NORs) demonstrated by a silver staining technique in paraffin sections, have been used to distinguish between benign and malignant lesions. AgNORs were studied in 24 biopsies from oral cavity (5 cases of normal oral mucosa, 5 of pseudocarcinomatous hyperplasia and 14 of squamous cell carcinoma, subdivided according to degree of differentiation: 5 grade 1, 5 grade 2 and 4 grade 3) to find whether they were helpful in distinguishing pseudocarcinomatous hyperplasia due to chronic parasitic infections from squamous cell carcinoma. Two methods of counting AgNORs were used: (A) a simpler one which counts nucleolar clusters (AgNU) and satellite AgNORs and the other (B) counting all individual AgNORs, including those within AgNUs. In both methods the lowest mean values were observed for grade 3 carcinoma, while the highest belonged to grade 2 carcinoma. The simpler method (A) was the most useful because AgNU counts showed significant difference when pseudocarcinomatous hyperplasia was compared with grade 1 and 2 carcinomas, which are the most difficult to discriminate from it. However the overlapping of values render the technique of limited use in individual cases.
Aerobic deterioration influences the fermentative, microbiological and nutritional quality of maize and sorghum silages on farm in high quality milk and cheese production chains
Authors: Borreani Giorgio , Bernardes Thiago Fernandes , Tabacco Ernesto
Published: June 2009

Maize and sorghum silages are good sources of energy for lactating dairy cows that produce milk destined for fresh and matured cheeses. Silages are usually stored in horizontal silos with or without side walls on commercial farms throughout the world. The main microbiological and nutritional quality problems are related to harvesting time, ensiling technology, and management practices during filling and feed-out. Aerobic deterioration is a key point that must avoided on farms in order to improve the hygienic, chemical and sensorial quality of milk and cheeses. Aerobic deterioration causes large losses of dry matter (DM) and quality, and it can cause health problems for animals and humans through the transfer of pathogens and mycotoxins from feed and livestock to food products. The objectives of the present work were to overview management practices connected to the storage of maize and sorghum in horizontal silos on farms producing milk for make Protected Designation of Origin (PDO) hard ripened cheese, to define good management practices that should be applied as the basis for safe silage production and to reduce the extent of aerobic deterioration.
Carcass and meat lamb and kid quality and development of consumer acceptability
Authors: Sañudo Astiz Carlos
Published: June 2009

Small ruminants have been one of the first domesticated species and from their origins have produced multiple benefits to humans. In the last two centuries, world sheep production has become more and more specialised upon geographical areas. But, recent changes in consumer attitudes, together with the increment in artificial fibre industries and human world population, some crisis related with the international wool market and some increments in lamb prices, have provoked that lamb meat has increased its relative importance inside the global sheep income. Also, sheep production systems vary considerably across the world, and reflect the different local environmental conditions, which determine, to a large extent, breeds, housing, levels of intensification and, at the end, local market requirements and qualities. However, among all the meats, sheep meat remains the most internationally traded (16 % of total world production is exported), which explains the potential existence of different lamb products in the same market. Then, the new requirements have created a higher interest for meat production, including its quality and quality marks. This interest from producers and the industry should be reflected in a proportional higher interest from the researches towards sheep and goat, where it exists, in general, important lacks of knowledge and, in particular, in lamb and kid meat Science. In the present speech we will made a special incidence on the relationship between carcass quality and lamb acceptability and on some factors like breed and species, diet and production system, slaughter weight and ageing time and their importance on the variation of the carcass and meat quality, including consumer acceptability.
Avaliação "in vivo" da composição corporal e da carcaça de caprinos: uso de ultrasonografia
Authors: Teixeira Alfredo
Published: June 2009

Atendendo ao crescente interesse na produção e consumo de carne de caprinos e à cada vez maior necessidade de recorrer a metodologias rápidas que proporcionem a predição da composição corporal e qualidade da carcaça, realizamos uma revisão dos últimos trabalhos realizados com recurso à técnica dos ultra-sons. Após uma breve resenha histórica sobre a evolução do uso do método na caprinicultura, são referidos os princípios da técnica e a sua aplicação aos caprinos (operador, identificação de pontos anatómicos de medida, diferentes medidas corporais e na carcaça, tipos de aparelhos e sondas e acondicionamento animal). São posteriormente analisados os resultados das principais pesquisas recentemente efectuadas. Finalmente são discutidas as expectativas futuras para o uso da técnica de ultra-sons na avaliação in vivo de caprinos, com referência a diferentes procedimentos para a obtenção de modelos de predição.
Entrenamiento y adaptación muscular: sustratos y vías metabólicas para la producción de energía
Authors: Boffi Federico Martín
Published: June 2009

Tres isoformas de MyHC han sido caracterizadas en músculo esquelético de equinos adultos a nivel proteico: tipo I, IIA y IIX. La distribución de estas MyHCs definen tres tipos puros de fibras que contienen una sola isoforma (tipo I, IIA y IIX) y dos tipos de fibras híbridas que expresan dos isoformas (I+IIA y IIAX). Las fibras híbridas IIAX existen en los músculos locomotores como una población estable y significativa. Dependiendo de la naturaleza del estímulo, la respuesta adaptativa puede tomar diferentes formas: hipertrofia, remodelación sin hipertrofia y respuesta mixta, cuando se combina la remodelación con la hipertrofia. Los equinos pueden aprovechar diferentes sustratos energéticos, algunos de los cuales son utilizados en forma inmediata tras la ingesta, mientras que otros son almacenados en el hígado, músculos y tejido adiposo para ser usados en otro momento. El glucógeno muscular y la glucosa pueden ser degradados por la vía aeróbica (oxidativa) o la anaeróbica lactacida (glucolítica), mientras que en ejercicios de resistencia la utilización de ácidos grasos se realiza a partir de la degradación de triglicéridos almacenados en el tejido celular subcutáneo. El metabolismo oxidativo mide la función de los sistemas cardiovascular y respiratorio. En cambio, el metabolismo anaeróbico solo involucra al tejido muscular.
Testes genéticos na eqüideocultura
Authors: Coelho Eduardo Geraldo Alves , Oliveira Denise Aparecida Andrade de
Published: June 2009

Nos últimos anos a equideocultura deu um salto qualitativo, havendo hoje, no mercado, animais de alto valor e geneticamente superiores. Isso é possível, em grande parte, devido aos avanços na área da genética animal, os quais permitem identificar, não apenas anomalias, mas também diversos genes de interesse econômico. Com o auxílio da citogenética pode-se identificar indivíduos com alterações no número ou na estrutura dos cromossomos, o que em muitos casos afeta principalmente a reprodução. Também a confirmação de genealogia, anteriormente feita por tipagem sangüínea e atualmente por testes de DNA, tem papel extremamente importante, não apenas por garantir a ascendência dos animais, mas também porque um pedigree confiável pode permitir ao criador identificar a origem de problemas genéticos em seu rebanho e reduzi-los ou mesmo, eliminá-los. Ainda com as ferramentas da biologia molecular, podemos hoje, identificar indivíduos que apresentam genes desejáveis ou indesejáveis, o que nos permite selecioná-los precocemente, reduzindo assim, os custos do produtor e aumentando o valor agregado dos animais. Entre tais genes podemos destacar os que identificam portadores ou afetados por mutações genéticas indesejáveis como: SCID (Síndrome da Imunodeficiência Combinada), HYPP (Parilisa Hipercalêmica), HERDA (Astenia Dérmica Regional Hereditária Eqüina), etc. Também a identificação dos genes que determinam a cor ou padrão da pelagem já pode ser feita direta ou indiretamente (por meio de marcadores genéticos), como é o caso dos genes para as pelagens Overo, Tobiano, etc. Com os avanços no estudo do genoma eqüino muito mais estará disponível em breve, o que certamente só trará maiores contribuições à equideocultura mundial.
Technologies to mitigate the environmental impact of broiler production
Authors: Oviedo-Rondón Edgar O.
Published: June 2009

The broiler industry produces efficiently animal protein, but generates residues with high contents of N, P, K, trace minerals, and high bacterial charge. The rapid microbial decomposition of these residues cause ammonia volatilization, nuisance odor, fine particulate matter, and attract insects and rodents. This presentation will discuss the more effective methods to utilize these resources and minimize potential environmental impact. These procedures include planning, personnel training, zoning of areas used to dispose the final residues in crop lands, farm isolation, precision nutrition, litter and house management practices, and appropriate mortality disposal. Broiler litter has been used for animal feeding and power generation. Additionally, new technologies to reduce ammonia, odor and fine particle emissions, or reduction of P solubility will be presented.
Utilização de subprodutos da indústria de biodiesel na alimentação de ruminantes
Authors: Abdalla Adibe Luiz , Silva Filho José Cleto da , Godoi Antonio Roberto de , Carmo Carolina de Almeida , Eduardo José Luiz de Paula
Published: June 2009

Com a introdução de óleo vegetal na cadeia produtiva do biocombustível no Brasil, é esperado o aumento da demanda por plantas oleaginosas e oferta de fibras vegetais resultantes da extração do óleo. Considerando a alimentação animal como elo entre a produção de biodiesel e a pecuária, propomos o estudo da utilização de subprodutos destes empreendimentos na alimentação visando aumentar a produtividade e diminuir a emissão de gases de efeito estufa pelos animais, gerando créditos de carbono e atendendo ao interesse da iniciativa privada. A técnica de produção de gases in vitro tem sido utilizada no LANA-CENA/USP com a finalidade de estudar o efeito de alimentos que possuem metabólitos secundários bioativos, na fermentação ruminal e degradabilidade da matéria orgânica (MOVD), bem como, no estudo da produção de metano. Resultados recentes mostraram que a substituição total do farelo de soja por tortas de algodão, dendê, mamona e pinhão manso proporcionou menor produção total de gases; e que a produção de metano foi significativamente afetada pela inclusão das tortas, sendo que o farelo de soja apresentou produção de metano de 15,3 mL/g MOVD. Diversos trabalhos mostram que as tortas e farelos apresentam características nutricionais adequadas para inclusão na dieta de ruminantes, entretanto, estudos criteriosos desses materiais enquanto matérias-primas para ração animal são necessários para avaliar possíveis efeitos deletérios devido à presença de metabólitos bioativos. Através de análises de cromatografia de alta resolução, podem ser identificadas essas substâncias que, em condições tropicais podem não apresentar a mesma toxicidade. A introdução de tortas com elevado teor de gordura nas dietas de ruminantes pode auxiliar na mitigação de metano entérico, e a produção de algumas oleaginosas pode contribuir com o seqüestro de carbono pelos solos de Cerrado na recuperação de pastagens, reduzindo a necessidade de desmatamentos.
Acurácia do exame clínico no diagnóstico da DPOC
Authors: Mattos Waldo Luís Leite Dias de , Signori Leonardo Gilberto Haas , Borges Fernando Kessler , Bergamin Jorge Augusto , Machado Vivian
Published: June 2009

OBJETIVO: A DPOC é um problema de saúde pública, e métodos diagnósticos simples podem ser úteis para facilitar o diagnóstico desta doença. O objetivo deste estudo foi avaliar a acurácia de variáveis clínicas para o diagnóstico de DPOC. MÉTODOS: Pacientes com DPOC e controles foram prospectivamente avaliados por dois examinadores quanto a nove variáveis clínicas. A razão de verossimilhança para o diagnóstico de DPOC foi determinada utilizando-se o modelo de regressão logística. RESULTADOS: Foram incluídos 98 pacientes com DPOC (idade média, 62,3 ± 12,3 anos; VEF1 médio, 48,3 ± 21,6%) e 102 controles. A razão de verossimilhança e IC95% para o diagnóstico de DPOC foram: 4,75 (2,29-9,82; p < 0,0001) para uso da musculatura acessória; 5,05 (2,72-9,39; p < 0,0001) para respiração com os lábios semicerrados; 2,58 (1,45-4,57; p < 0,001) para tórax em barril; 3,65 (2,01-6,62; p < 0,0001) para redução da expansibilidade torácica; 7,17 (3,75-13,73; p < 0,0001) para redução do murmúrio vesicular; 2,17 (1,01-4,67; p < 0,05) para índice torácico > 0,9; 2,36 (1,22-4,58; p < 0,05) para comprimento laríngeo < 5,5 cm; 3,44 (1,92-6,16; p < 0,0001) para tempo expiratório forçado > 4 s; e 4,78 (2,13-10,70; p < 0.0001) para limite inferior do fígado > 4 cm abaixo do rebordo costal. A concordância entre observadores para as mesmas variáveis foi, respectivamente, 0,57, 0,45, 0,62, 0,32, 0,53, 0,32, 0,59, 0,52 e 0,44 (p < 0,0001 para todas). CONCLUSÕES: Vários achados do exame clínico podem ser utilizados como testes diagnósticos para DPOC.
Comparação entre três equações de referência para a espirometria em crianças e adolescentes com diferentes índices de massa corpórea
Authors: Drumond Sarah Costa , Fontes Maria Jussara Fernandes , Assis Irmgard de , Duarte Marco Antônio
Published: June 2009

OBJETIVO: Comparar o VEF1 e a CVF, calculados a partir de três equações de referência (idealizadas por Polgar e Promadhat, Hsu et al. e Mallozi em 1971, 1979 e 1995, respectivamente) e verificar se estas se equivalem ao predizer a função pulmonar em crianças e adolescentes com diferentes índices de massa corpórea (IMC). MÉTODOS: Os indivíduos foram divididos em quatro grupos: baixo peso (BP), eutrófico (E), sobrepeso (SP) e obeso (O), de acordo com o padrão de referência do National Center for Health Statistics, e então submetidos ao teste espirométrico. RESULTADOS: Foram avaliadas 122 crianças e adolescentes saudáveis com idade entre 7-14 anos. Os valores de CVF previstos pela equação de Hsu et al. nos grupos E (feminino) e BP (masculino), assim como os valores de VEF1 previstos pelas equações de Polgar e Promadhat e Hsu et al. nos grupos BP (feminino e masculino), foram significativamente superiores aos valores medidos. De acordo com a equação de Polgar e Promadhat, os valores de VEF1 previstos foram significativamente superiores aos valores medidos no grupo E (feminino). CONCLUSÕES: Não houve equivalência dos valores de CVF e VEF1, medidos em indivíduos com diferentes IMC, e os previstos pelas equações de Polgar e Promadhat e de Hsu et al. O mesmo não ocorreu quando as equações de Mallozi foram utilizadas. O IMC não foi um fator importante para o índice preditivo nas equações de Mallozi, podendo ser utilizadas indistintamente em crianças e adolescentes com diferentes IMC.
Validação de um protocolo para o teste de caminhada de seis minutos em esteira para avaliação de pacientes com hipertensão arterial pulmonar
Authors: Camargo Viviane Moreira de , Martins Barbara do Carmo dos Santos , Jardim Carlos , Fernandes Caio Julio Cesar , Hovnanian Andre , Souza Rogério
Published: June 2009

OBJETIVO: Elaborar e validar um protocolo para teste de caminhada de seis minutos em esteira (TC6est) para a avaliação de pacientes com hipertensão arterial pulmonar (HAP). MÉTODOS: A população do estudo foi composta por 73 pacientes com HAP diagnosticados através de cateterismo cardíaco direito, com ou sem inalação de NO. Todos os pacientes realizaram um TC6 em solo e três TC6est baseados em um protocolo de incremento de velocidade pré-determinado e intercalados por um período de repouso. Os pacientes que haviam realizado o teste hemodinâmico com inalação de NO realizaram o terceiro TC6est com a inalação da mesma dose de NO utilizada durante o cateterismo. RESULTADOS: Os resultados mostraram uma correlação da distância caminhada no TC6est com os dados hemodinâmicos, assim como com a classe funcional e com a distância caminhada no solo. Além disso, a distância percorrida no TC6est apresentou uma correlação significativa com a sobrevida, confirmando, portanto, sua correlação com a gravidade da doença. A inalação de NO durante o TC6est levou a variações compatíveis com as variações hemodinâmicas frente à mesma dose de NO, sugerindo que o protocolo em questão pode refletir o efeito de intervenções terapêuticas. CONCLUSÕES: Concluímos que a distância percorrida no TC6est é um marcador funcional e prognóstico na avaliação de rotina de pacientes com HAP.
Bacterial pneumonia following bone marrow transplantation: HRCT findings
Authors: Coelho Luiz Otávio de Mattos , Gasparetto Taísa Davaus , Escuissato Dante Luiz
Published: June 2009

OBJECTIVE: To describe HRCT findings in patients with bacterial pneumonia following bone marrow transplantation (BMT). METHODS: This was a retrospective study involving 30 patients diagnosed with bacterial pneumonia in whom HRCT of the chest was performed within 24 h after the onset of symptoms and the diagnosis was confirmed, based on a positive culture of sputum or bronchial aspirate, together with a positive pleural fluid or blood culture, within one week after symptom onset. There were 20 male patients and 10 female patients. The median age was 21 years (range, 1-41 years). The BMT had been performed for the treatment of the following: chronic myeloid leukemia, in 14 cases; severe aplastic anemia, in 6; acute myeloid leukemia, in 4; Fanconi's anemia, in 3; and acute lymphocytic leukemia, in 3. Two radiologists analyzed the HRCT scans and reached their final decisions by consensus. RESULTS: The most common HRCT findings were air-space consolidation (in 60%), small centrilobular nodules (in 50%), ground-glass opacities (in 40%), bronchial wall thickening (in 20%), large nodules (in 20%), pleural lesions (in 16.7%) and tree-in-bud opacities (in 10%). The pulmonary lesions were distributed in the central and peripheral areas in 15 patients, whereas they were exclusively peripheral in 11. Lesions were located in the lower and middle lobes of the lung in 22 and 20 patients, respectively. CONCLUSIONS: The most common HRCT findings in our patient sample were air-space consolidation, small centrilobular nodules and ground-glass opacities, most often in the central and peripheral regions of the middle and lower lung zones.
The impact of smoking cessation on patient quality of life
Authors: Sales Maria Penha Uchoa , Oliveira Maria Irenilza , Mattos Isabela Melo , Viana Cyntia Maria Sampaio , Pereira Eanes Delgado Barros
Published: June 2009

OBJECTIVE: To evaluate changes in health-related quality of life (HRQoL) after twelve months of smoking cessation. METHODS: This was a prospective study to evaluate the effectiveness of a smoking cessation program on the quality of life of 60 self-referred subjects, at a public hospital, during the period of August 2006 to December 2007. The program consisted of 2-h group sessions once a week during the first month and then every 15 days over six months, followed by monthly phone contacts for another six months. The treatment was based on behavior modification and the use of bupropion in combination with nicotinic replacement therapy. Abstinence was verified by exhaled CO measurements. Patient HRQoL was quantified using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) questionnaire. Differences in quality of life scores between quitters and non-quitters at twelve months after the initial intervention were evaluated using analysis of covariance with baseline characteristics as covariates. RESULTS: Self-reported quality of life scores were significantly higher among the 40 quitters than among the 20 non-quitters. The following SF-36 domains were most affected: role-emotional (p = 0.008); general health (p = 0.006); vitality (p < 0.001); and mental health (p = 0.002). At twelve months after the smoking cessation intervention, the SF-36 mental component and physical component summary scores were higher among quitters than among non-quitters (p = 0.004 and p = 0.001, respectively). CONCLUSIONS: Our findings illustrate that smoking abstinence is related to better HRQoL, especially in aspects of mental health.
Atendimento fisioterapêutico no pós-operatório imediato de pacientes submetidos à cirurgia abdominal
Authors: Forgiarini Junior Luiz Alberto , Carvalho Alexandra Torres de , Ferreira Tatiane de Souza , Monteiro Mariane Borba , Bosco Adriane Dal , Gonçalves Marisa Pereira , Dias Alexandre Simões
Published: June 2009

A cirurgia abdominal causa uma série de complicações pulmonares após o processo cirúrgico. Assim, faz-se necessário um tratamento precoce adequado objetivando minimizar as complicações no período pós-operatório. Objetivamos avaliar o efeito do atendimento fisioterapêutico no pós-operatório imediato de pacientes submetidos à cirurgia abdominal. Este foi um ensaio clínico randomizado, no qual um grupo recebeu atendimento fisioterapêutico na sala de recuperação e, posteriormente, nas enfermarias, e outro grupo o recebeu somente nas enfermarias. Concluímos que a fisioterapia realizada no pós-operatório imediato reduziu a perda da função pulmonar, a perda da força muscular ventilatória e o tempo de internação na sala de recuperação.
Infecção pelo vírus Influenza A (H1N1) de origem suína: como reconhecer, diagnosticar e prevenir
Authors: Machado Alcyone Artioli
Published: June 2009

Em março de 2009, houve o início de uma epidemia de gripe no México que, em pouco tempo, levou ao surgimento de casos semelhantes em outros países, alertando as autoridades sanitárias para o risco de uma pandemia. Neste artigo, descrevemos os principais sinais e sintomas da infecção pelo vírus Influenza A (H1N1) de origem suína, as medidas a serem tomadas para os casos suspeitos ou confirmados e como proceder em relação aos contactantes. Comentamos também quais drogas são utilizadas para o tratamento e profilaxia.
Gripe aviária: a ameaça do século XXI
Authors: Andrade Cláudia Ribeiro de , Ibiapina Cássio da Cunha , Champs Natália Silva , Toledo Junior Antonio Carlos Castro de , Picinin Isabela Furtado de Mendonça
Published: June 2009

Este estudo teve como objetivo fazer uma revisão da literatura a respeito da infecção pelo vírus influenza A subtipo H5N1, levando em conta a possibilidade de as crianças serem um dos grupos etários mais acometidos caso ocorra uma pandemia. A revisão bibliográfica foi realizada nos seguintes bancos de dados, restrita aos últimos 10 anos: Medline, MD Consult, HighWire e Medscape. As crianças e os adultos jovens representam uma fração importante da população susceptível. Mais da metade dos indivíduos infectados apresentavam menos de 20 anos de idade, e um quarto era menor do que 10 anos. O período de incubação variou de 2 a 5 dias. As manifestações clínicas iniciais são não específicas, o que dificulta o diagnóstico. A maioria dos casos apresentou um quadro de pneumonia grave, que evoluiu para insuficiência respiratória em 4 dias em média. A radiografia de tórax pode mostrar infiltrado intersticial difuso ou multifocal ou consolidação lobar ou segmentar com broncograma aéreo. A infecção tem alta patogenicidade, com 63% de letalidade, o que indica que o vírus pandêmico também pode apresentar alta patogenicidade com mortalidade elevada. O conhecimento sobre os riscos da pandemia e sobre as medidas que podem ser tomadas em casos suspeitos é um importante passo para o controle de uma possível pandemia.
Aspergilloma formation in cavitary sarcoidosis
Authors: Panjabi Chandramani , Sahay Sandeep , Shah Ashok
Published: June 2009

Pulmonary cavitation is rather uncommon in patients with sarcoidosis, and aspergilloma is even more uncommon in such cases. Here, we present the case of a 63-year-old female patient with cavitary lung disease who had been under treatment for TB for 9 months. A diagnosis of pulmonary sarcoidosis was established based on the fiberoptic bronchoscopy finding of noncaseating granuloma. Treatment with corticosteroids led to a dramatic improvement in symptoms. While under treatment for sarcoidosis, the patient developed an aspergilloma. She presented immediate skin test reactivity to Aspergillus fumigatus, as well as positivity for A. fumigatus serum precipitins. This is the first reported case of aspergilloma formation in a patient with cavitary sarcoidosis in India.
Hiperplasia de células neuroendócrinas pulmonares difusas com obstrução ao fluxo aéreo
Authors: Coletta Ester Nei Aparecida Martins , Voss Larissa Rêgo , Lima Mariana Silva , Arakaki Jaquelina Sonoe Ota , Câmara Juvêncio , D'Andretta Neto Carlos , Pereira Carlos Alberto de Castro
Published: June 2009

A hiperplasia de células neuroendócrinas pulmonares difusas com obstrução ao fluxo aéreo é uma lesão pulmonar rara. Todos os casos publicados foram diagnosticados por biópsia pulmonar cirúrgica. Apenas três casos relatados apresentavam opacidades intersticiais difusas na TCAR. Nós relatamos três casos adicionais desta entidade. Todos eram mulheres, com obstrução leve ou moderada ao fluxo aéreo. No primeiro caso, uma biópsia transbrônquica, associada com dados de imagem foram considerados suficientes para o diagnóstico. Um padrão em mosaico foi observado nos três casos, mas no terceiro um infiltrado pulmonar difuso foi também observado. Em casos muito raros, o aspecto na TCAR pode simular aquele encontrado em outras doenças pulmonares intersticiais.
Weed Management Using Reduced Rate Combinations of Diclosulam, Flumioxazin, and Imazapic in Peanut
Authors: Ducar J. Tredaway , Clewis S. B. , Wilcut J. W. , Jordan D. L. , Brecke B. J. , Grichar W. J. , Johnson W. C. , Wehtje G. R.
Published: June 2009

Experiments were conducted during 2000 and 2001 at a total of 13 locations throughout Alabama, Georgia, Florida, North Carolina, and Texas to evaluate efficacy of herbicides at or below the manufacturer's suggested use rate. Herbicide applications included diclosulam and flumioxazin applied PRE alone or followed by imazapic applied early postemergence (EPOST). All possible combinations of diclosulam at 0, 13.5, or 27 g ai/ha and flumioxazin at 0, 53, or 105 g ai/ha applied PRE were included. Imazapic was applied at 35 g ai/ha. Ivyleaf morningglory was controlled more than 87% when imazapic was applied EPOST regardless of PRE herbicide. Pitted morningglory control > 67% was observed with applications of diclosulam (27 g/ha) followed by imazapic, diclosulam (13.5 g/ha) plus flumioxazin (53 g/ha), diclosulam (13.5 g/ha) plus flumioxazin (105 g/ha), and diclosulam (27 g/ha) plus flumioxazin (105 g/ha). Sicklepod was controlled more than 74% with flumioxazin (53 g/ha) followed by imazapic and diclosulam (27 g/ha) plus flumioxazin (105 g/ha) followed by imazapic. Florida beggarweed was controlled more than 84% by all PRE herbicide combinations except flumioxazin (53 g/ha) alone or diclosulam (27 g/ha) alone or with imazapic. Yellow nutsedge was controlled at least 90% with diclosulam at either rate followed by imazapic and by diclosulam plus flumioxazin followed by imazapic regardless of rate. Pod yield was generally higher when herbicides were applied regardless of herbicide combination or rate. Peanut yield was maximized with the lowest rates of flumioxazin or diclosulam PRE followed by imazapic EPOST.
Herbicide Selection and Application Timing for Control of Cressleaf Groundsel (Packera glabella)
Authors: Lake Jeremy T. , Hager Aaron G.
Published: June 2009

Field experiments were conducted from 2004 through 2006 to evaluate cressleaf groundsel control following fall or early-spring preplant herbicide applications. Glyphosate, glyphosate + imazethapyr, glyphosate + 2,4-D ester, paraquat, paraquat + simazine, chlorimuron + tribenuron, and pendimethalin + glyphosate + 2,4-D ester applied in the fall controlled at least 93% of the cressleaf groundsel. Glyphosate, glyphosate + imazethapyr, glyphosate + 2,4-D ester, chlorimuron + tribenuron, and pendimethalin + glyphosate + 2,4-D ester applied in the spring provided at least 94% control of the cressleaf groundsel. Chlorimuron + tribenuron provided at least 98% control, regardless of application timing. These results indicate that herbicides applied in the fall or early spring can control cressleaf groundsel. However, certain herbicides provide greater control when applied in the fall compared with spring.
Ability of Potato Cultivars to Tolerate and Suppress Weeds
Authors: Colquhoun Jed B. , Konieczka Christopher M. , Rittmeyer Richard A.
Published: June 2009

Potato producers rely heavily on herbicides for the majority of weed control. However, recent occurrences of herbicide-resistant weed populations and the lack of new herbicide registrations have stimulated interest in alternative strategies. The choice of potato cultivars that can suppress or tolerate weed competition could be a component of an integrated weed management system to reduce reliance on herbicides. The competitive ability of 10 potato cultivars—‘Atlantic’, ‘Bannock Russet’, ‘Dark Red Norland’, ‘Goldrush’, ‘Rodeo’, ‘Russet Burbank’, ‘Russet Norkotah’, ‘Snowden’, ‘Superior’, and ‘Villetta Rose’—was evaluated in 2006 and 2007 in Hancock, WI. Weed competition treatments included (1) weedy throughout the season, (2) weed-free from emergence to 4 wk after emergence (WAE) by hand-weeding, and (3) weed-free by hand-weeding for the entire season. Potato cultivars did not differ in ability to reduce weed biomass. Early-season time of potato emergence and canopy closure, as well as weed competition treatments, were strongly related to potato tuber yield. In general, Bannock Russet yield relative to weed-free controls of the same cultivar was less than that of most other cultivars. Overall, Atlantic, Russet Burbank, Snowden, and Superior yields (relative to weed-free control yields) usually were greater than the yields of other cultivars under weedy conditions. Although the ability to suppress weeds was similar among cultivars, differences in yield among cultivars grown in the presence of weeds suggest differential tolerances of weed competition.
Effect of Tillage and Soil-Applied Herbicides with Micro-Rate Herbicide Programs on Weed Control and Sugarbeet Growth
Authors: Bollman Scott L. , Sprague Christy L.
Published: June 2009

Field trials were conducted to determine if tillage and soil-applied herbicides had an effect on weed control and sugarbeet growth with a micro-rate herbicide program. Sugarbeet emergence was earlier in the moldboard plowed system compared with the chisel plowed system at three of four sites. Conditions were dry and sugarbeets emerged 5 d later in the moldboard plowed system compared with the chisel plowed system at the fourth site. Even though the rate of sugarbeet emergence differed between tillage systems at all four sites, final sugarbeet populations did not differ at two of the four sites. Sugarbeet injury from PRE treatments ofS-metolachlor, ethofumesate, and ethofumesate plus pyrazon, followed by four POST micro-rate applications, ranged from 11 to 27% and 1 to 18% in the chisel and moldboard plowed systems, respectively, 6 wk after planting (WAP). Under wet conditions, sugarbeet stand was reduced and injury was greatest from PRE applications ofS-metolachlor. Common lambsquarters, pigweed (redroot pigweed and Powell amaranth), and giant foxtail control in mid-August was consistently higher when a PRE herbicide was applied prior to micro-rate herbicide treatments. Even though there were differences between PRE and no-PRE treatments with respect to sugarbeet injury and weed control, recoverable white sucrose yield did not differ between herbicide treatments. However, recoverable white sucrose yield was greater in the moldboard plowed treatments compared with the chisel plowed treatments at three out of the four sites.
Dose Responses of Five Broadleaf Weeds to Saflufenacil
Authors: Geier Patrick W. , Stahlman Phillip W. , Charvat Leo D.
Published: June 2009

Greenhouse dose–response studies were conducted to determine the effectiveness of PRE and POST applications of saflufenacil on blue mustard, flixweed, Palmer amaranth, redroot pigweed, and tumble pigweed. Weed species did not differ in their responses to saflufenacil applied PRE. Averaged across species, PRE application of saflufenacil at 6 to 30 g/ha reduced weed biomass 82 to 98%, but biomass did not differ among rates of 12 g/ha or higher. POST application of saflufenacil reduced weed biomass by 92%, averaged across species and rates. On the basis of regression analysis, the 90% plant biomass reduction for saflufenacil applied PRE and POST was 9 and 6 g/ha, respectively. Saflufenacil applied PRE reduced population density by 77 to 98%, averaged across weed species; a rate of 9 g/ha reduced population density 90% (DR90) on the basis of regression analysis. Averaged across species, POST application of 6 to 30 g/ha reduced population density by 63 to 93%, but regression analysis indicated that the DR90 value was greater than 30 g/ha. Averaged across rates, saflufenacil reduced the population density of flixweed, Palmer amaranth, redroot pigweed, tumble pigweed, and blue mustard by 49, 64, 67, 73, and 78%, respectively.
Establishing the Geographical Distribution and Level of Acetolactate Synthase Resistance of Palmer Amaranth (Amaranthus palmeri) Accessions in Georgia
Authors: Wise Aaron M. , Grey Timothy L. , Prostko Eric P. , Vencill William K. , Webster Theodore M.
Published: June 2009

Palmer amaranth resistance to acetolactate synthase (ALS)–inhibiting herbicides was first identified in Georgia in 2000. Since then, complaints from peanut producers have increased concerning failure of ALS herbicides in controlling Palmer amaranth. Because efficacy of ALS herbicides can be compromised under adverse conditions, seeds from Palmer amaranth plants that escaped weed control were collected across the peanut-growing region in Georgia to investigate the cause of these reported failures. Greenhouse and growth-chamber studies were conducted using these seeds to evaluate whether weed escapes were a result of Palmer amaranth resistance to ALS herbicides. Each of the 61 accessions collected across Georgia exhibited varying levels of resistance to imazapic applied POST (< 55% control, relative to ALS-susceptible Palmer amaranth). Subsamples of the accessions were evaluated for their response to imazapic rates, which indicated variable levels of resistance across Palmer amaranth accessions. The rate of imazapic that provided 50% reduction in Palmer amaranth plant biomass (I50) for the known susceptible biotype was 0.9 g/ha of imazapic. Of the 10 accessions evaluated, 8 of them had I50values that ranged from 3 to 297 g/ha of imazapic. The other two accessions could not be fit to the log-logistic dose–response curve and had undeterminable I50values because of high levels of ALS resistance (> 1,400 g/ha of imazapic). Herbicide cross-resistance experiments indicated that 30 accessions were resistant to the ALS herbicides imazapic, chlorimuron, pyrithiobac, and diclosulam at the recommended field-use rates. However, each of these 30 accessions was susceptible to glyphosate. These data demonstrate that ALS-resistant Palmer amaranth occurs throughout the peanut-growing region of Georgia. Growers in Georgia will need to alter their weed-control programs in peanut to include herbicides with multiple modes of action that do not rely on ALS herbicides for effective Palmer amaranth control.