bluuebunny/crossref_metadata_2025 huggingface dataset:
Dermatosis inducida por el agua: queratodermia acuagénica, a propósito de un caso
Authors: Montoya Camila , Arias Liza M. , Salazar Mónica , Restrepo Rodrigo
Published: September 2019

La queratodermia acuagénica es una entidad benigna, caracterizada por producir pápulas blanquecinas o traslúcidas pocos segundos después del contacto con el agua.Se presenta el caso de una paciente de 16 años de edad con aparición de múltiples pápulas confluentes y asintomáticas en ambas palmas al contacto con el agua, que desaparecían luego del secado. En el estudio de histopatología se observó dilatación de los conductos ecrinos y cambios en el estrato córneo.Esta rara condición de etiología desconocida se ha relacionado con disfunción neuronal, alteraciones de las glándulas ecrinas y, más recientemente, con alteraciones en las acuaporinas. Se puede diagnosticar con una prueba semiológica sencilla llamada ‘la mano en el balde’; la sospecha clínica es fundamental para hacer el diagnóstico, ya que los hallazgos histopatológicos pueden ser sutiles e inespecíficos. El tratamiento tópico incluye mecanismos de barrera y la toxina botulínica.
El biomodelo porcino en la investigación médica traslacional: del biomodelo al humano en trasplante pulmonar
Authors: Fernández Liliana , Velásquez Mauricio , Sua Luz Fernanda , Cujiño Indira , Giraldo Martha , Medina Diego , Burbano Mauricio , Torres Germán , Munoz-Zuluaga Carlos , Gutiérrez-Martínez Leidys
Published: September 2019

Introducción. La anatomía humana y porcina son comparables. En consecuencia, el biomodelo porcino tiene el potencial de ser implementado para entrenar al profesional quirúrgico en áreas como el trasplante de órganos sólidos.Objetivo. Describir los procedimientos y hallazgos obtenidos mediante experimentos de medicina respiratoria traslacional con biomodelos porcinos realizados en un laboratorio de experimentación animal, y hacer una revisión comparativa entre el pulmón humano y el porcino.Materiales y métodos. El experimento se llevó a cabo en nueve cerdos de raza híbrida en un laboratorio de cirugía experimental. Se estudiaron la anatomía y la histología de las vías respiratorias mediante fibrobroncoscopia, biopsia bronquial y lavado broncoalveolar. El lavado broncoalveolar se estudió con citología en base líquida y se evaluó con las coloraciones de Papanicolau y hematoxilina y eosina. Se utilizaron técnicas de patología molecular, como inmunohistoquímica, citometría de flujo y microscopía electrónica. Los cerdos se sometieron a neumonectomía izquierda con posterior implante del injerto en otro cerdo experimental.Resultados. Los estudios histopatológicos y moleculares evidenciaron un predominio de macrófagos alveolares (98 %) y linfocitos T (2 %) en el lavado broncoalveolar porcino. En los estudios del parénquima pulmonar porcino se encontró tejido linfoide hiperplásico asociado a las paredes bronquiales. La microscopía electrónica evidenció linfocitos T dentro del epitelio y el diámetro de las cilias porcinas fue similar al de las humanas.Conclusiones. El biomodelo porcino es viable en la investigación traslacional para el entendimiento de la anatomía del sistema respiratorio y el entrenamiento en trasplante pulmonar. La implementación de este modelo experimental podría fortalecer los grupos que planean implementar un programa institucional de trasplante pulmonar en humanos.
Experiencia de un centro colombiano en el tratamiento endovascular de la hemorragia posparto que amenaza la vida
Authors: Escobar María Fernanda , Velásquez Jorge Guillermo , Holguín Alejandra , Sánchez Joselin , Messa Adriana , Carvajal Javier Andrés , Nieto Albaro José
Published: September 2019

Introducción. La hemorragia posparto es la primera causa de morbimortalidad materna en el mundo y las laceraciones son la segunda causa en frecuencia. Su tratamiento temprano y apropiado es clave para obtener buenos resultados, y la oclusión endovascular de los vasos pélvicos se cuenta entre las opciones terapéuticas.Objetivo. Describir la experiencia del tratamiento con la ‘embolización’ (sic) arterial de los vasos pélvicos.Materiales y métodos. Se trató de un estudio retrospectivo del tipo de serie de casos basado en el registro institucional de la Fundación Valle del Lili, Cali, Colombia, en el que se incluyeron las pacientes con hemorragia posparto atendidas entre el 1º de enero del 2011 y el 31 de octubre del 2016.Resultados. De las 430 pacientes con diagnóstico de hemorragia posparto, 11 fueron sometidas a la ‘embolización’ de los vasos pélvicos. De este grupo, 10 pacientes tuvieron parto vaginal con laceraciones vaginales complejas, y la mayoría (9 casos, 82 %) fue remitida por otras instituciones de menor complejidad después de 20,5 horas. Las arterias ocluidas frecuentemente fueron la vaginal superior y la pudenda interna. Ninguna paciente presentó complicaciones asociadas al procedimiento y solo dos presentaron sangrado recurrente. Tres pacientes requirieron histerectomía y ninguna murió.Conclusión. El manejo percutáneo es un método de tercera línea, seguro y efectivo para el control de los sangrados de difícil manejo en las pacientes con hemorragia pospartopor desgarros perineales complejos. Estos resultados son similares a los reportados en la literatura científica mundial disponible hasta la fecha.
Geographical distribution of Leishmania species in Colombia, 1985-2017
Authors: Salgado-Almario Jussep , Hernández Carlos Arturo , Ovalle Clemencia Elena
Published: September 2019

Introduction: Knowledge of the geographical distribution of Leishmania species allows guiding the sampling to little-studied areas and implementing strategies to define risk zones and priority areas for control.Objective: Given that there is no publication that collects this information, the search, review, and compilation of the available scientific literature that has identified species in Colombia is presented in this paper.Materials and methods: A bibliographic search was performed in PubMed, Web of Knowledge, Google Scholar, SciELO and LILACS with the terms “(Leishmania OR Leishmaniasis) AND species AND Colombia”, without restrictions on publication year, language or infected organism; records of national scientific events and repositories of theses from Colombian universities were also included.Results: Eighty-six scientific documents published between 1985 and 2017 were found in which the species of Leishmania and their geographical origin were indicated. The species reported, in descending order of frequency, were: Leishmania (Viannia) panamensis, L. (V.) braziliensis, L. (V.) guyanensis, L. (Leishmania) infantum, L. (L.) amazonensis, L. (L.) mexicana, L. (V.) colombiensis, L. (V.) lainsoni and L. (V.) equatorensis; the last three were found with the same frequency. Leishmania species were reported from 29 departments. Conclusion: Information on the distribution of Leishmania species in Colombia is limited; therefore, it is necessary to gather existing data and propose studies that consolidate the distribution maps of Leishmania species in Colombia. This would allow the detection of areas where species have not been identified as well as the comparison of existing parasite and vector distributions.
Validación de la sexta edición del Addiction Severity Index (ASI-6) (ISA-6) en población clínica de Colombia
Authors: Zapata Juan Pablo , García Jenny , Arroyave César Augusto , Calderón Juan Daniel , Gómez José Mario , Buitrago Doris Jacqueline , Aparicio Angélica , Aguirre Daniel Camilo
Published: September 2019

Introducción. Se recomienda el uso del Addicition Severity Index en su sexta versión (ASI-6) para establecer las necesidades del paciente con adicciones y evaluar la efectividad de los programas.Objetivo. Desarrollar una versión para Colombia del ASI-6 garantizando la equivalencia translingüística y transcultural, y evaluar su confiabilidad y la validez de constructo.Materiales y métodos. En el estudio se incluyeron adultos con trastornos debidos al uso de sustancias bajo tratamiento en centros de atención de la drogodependencia. Se adaptó la versión en español con base en la original en inglés y, posteriormente, se tradujo al inglés la versión así adaptada para determinar su equivalencia. Se evaluó la confiabilidad en cuanto a la consistencia interna, así como la reproducibilidad prueba-reprueba y la confiabilidad interevaluador. La validez convergente del constructo se comprobó mediante la correlación con cuestionarios que miden constructos similares a los subyacentes a cada subescala del ISA-6. Resultados. Se encontró una consistencia interna adecuada, con un alfa de Cronbach por encima de 0,7 en todas las subescalas, excepto la “Social” (α=0,66). La confiabilidad entre evaluadores y de la prueba-reprueba fueron altas, con coeficientes de correlación intraclase mayores de 0,7 en todas las subescalas. El aspecto convergente de la validez de constructo se demostró al obtener coeficientes de correlación de Spearman entre 0,53 y 0,88 en las subescalas del ISA-6 comparadas con cuestionarios que miden constructos similares.Conclusión. La versión del ISA-6 adaptada al contexto colombiano evidenció una confiabilidad y una validez de constructo adecuadas, por lo que puede introducirse en la clínica, aunque se requieren estudios para conocer su sensibilidad al cambio y su validez estructural.
Characterization of ceRNA network to reveal potential prognostic biomarkers in triple-negative breast cancer
Authors: Song Xiang , Zhang Chao , Liu Zhaoyun , Liu Qi , He Kewen , Yu Zhiyong
Published: September 2019

Triple-negative breast cancer (TNBC) is a particular subtype of breast malignant tumor with poorer prognosis than other molecular subtypes. Previous studies have demonstrated that some abnormal expression of non-coding RNAs including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) were closely related to tumor cell proliferation, apoptosis, invasion, migration and drug sensitivity. However, the role of non-coding RNAs in the pathogenesis of TNBC is still unclear. In order to characterize the molecular mechanism of non-coding RNAs in TNBC, we downloaded RNA data and miRNA data from the cancer genome atlas database. We successfully identified 686 message RNAs (mRNAs), 26 miRNAs and 50 lncRNAs as key molecules for high risk of TNBC. Then, we hypothesized that the lncRNA–miRNA–mRNA regulatory axis positively correlates with TNBC and constructed a competitive endogenous RNA (ceRNA) network of TNBC. Our series of analyses has shown that five molecules (TERT, TRIML2, PHBP4, mir-1-3p, mir-133a-3p) were significantly associated with the prognosis of TNBC, and there is a prognostic ceRNA sub-network between those molecules. We mapped the Kaplan–Meier curve of RNA on the sub-network and also suggested that the expression level of the selected RNA is related to the survival rate of breast cancer. Reverse transcription-quantitative polymerase chain reaction showed that the expression level of TRIML2 in TNBC cells was higher than normal. In general, our findings have implications for predicting metastasis, predicting prognosis and discovering new therapeutic targets for TNBC.
Correlation between 18F-FDG maximum standardized uptake value with CD147 expression in lung adenocarcinomas: a retrospective study
Authors: Guo Fei , Li Xueyan , Yao Guodong , Zeng Guangchun , Yu Lijuan
Published: September 2019

Background

The pro-tumoral action of the cluster of differentiation 147 (CD147), which is associated with the chemotherapy resistance of lung adenocarcinoma, is partly due to accelerated tumor cell glycolysis. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) metabolic parameters included maximal standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), which are non-invasive markers of the glucose metabolism of tumor cells in vivo. This study aimed to clarify the correlation between PET metabolic parameters and CD147 expression, and to evaluate the prognostic value of CD147 expression in resectable lung adenocarcinoma patients.

Methods

A total of 89 lung adenocarcinoma chemotherapy-naive patients who underwent 18F-fluorodeoxyglucose positron emission tomography and computerized tomography scan before pulmonary surgery were retrospectively analyzed. The PET metabolic parameters were calculated by 18F-FDG PET imaging, and CD147 expression was analyzed by immunohistochemistry. SUVmax, SUVmean, MTV, and TLG compared for their performance in predicting the expression of CD147 were illustrated with statistical analysis. All patients were then followed-up for survival analysis.

Results

The SUVmax was significantly correlated with the CD147 expression and was the primary predictor for the CD147 expression of lung adenocarcinoma. A cut-off value of the SUVmax, 9.77 allowed 85.1% sensitivity and 64.3% specificity for predicting the CD147 positive lung adenocarcinoma. CD147 expression was correlated with tumor differentiation and metastasis. Univariate survival analysis showed that CD147 expression was significantly associated with a shorter overall survival (OS) time. Multivariate analysis revealed that CD147 was an independent prognostic factor of lung adenocarcinoma patients.

Conclusion

The SUVmax of a primary tumor measured with 18F-FDG PET may be a simple and non-invasive marker for predicting CD147 expression in lung adenocarcinoma. CD147 is an independent prognostic factor related to OS of postoperative lung adenocarcinoma patients.
Development of Oil Spill Response Decision Support Tool for Aerial Spraying of Dispersants
Authors: Dillon-Gibbons Craig , Galtry Cameron , Boustead Nicholas , D'Arcy-Evans Nicholas , Kurts Phillip , Jal Eric , Kilner Andrew , Washington Daniel
Published: September 2019

2017-280 Abstract

This paper describes the development of a Decision Support Tool (DST) for response planning associated with aerial operations for offshore oil spills. The research program was formulated to include characterization of dispersant spray drift through numerical modeling to generate a database of drift response for a range of airframes and environmental conditions. The drift of aerial dispersants is dependent on a number of different influences including airframe shape and aerodynamics, environmental effects, flight conditions and aerial dispersant make up. As with agricultural spraying, oil spill response spraying has the potential of spray drift to impact upon ecologically sensitive regions and/or areas occupied by people or marine mammals surfacing in the spill area. The development of the DST included an evaluation of existing regulatory models, investigating their application to the offshore environment. It was found that, due to inherent limitations and simplifications, particularly for the larger airframes considered, the existing models were under conservative in comparison with Computational Fluid Dynamics (CFD) models in the near field wake regions for offshore spraying purposes. To address these issues, a combination of scaling factors and the use of inviscid vortex transport and particle dispersion models were adopted for inclusion in the DST. It is envisaged that, once validated further, the DST will become an invaluable tool for Oil Spill Response Operators (OSROs) and decision planners in both the operational mode of providing information to aid in establishing setback distances and in the planning mode to assist with the identification of windows of opportunity conducive to spraying operations.
Compliance Monitoring of Microbiological and Physicochemical Parameters of Abattoirs’ Effluents Discharged into Water Bodies in Owerri, Nigeria
Authors: Egesi Constance O. , Ezebuiro Victor , Ekeleme Anthony C. , Obiukwu Charles E.
Published: September 2019

Aims: To assess the quality of abattoir effluents discharged into water bodies in Owerri Municipal, Nigeria using microbiological and physicochemical approaches.

Study Design:  The study employed microbiological and physicochemical parameters to determine effluent and water quality.

Place and Duration of Study: Abattoirs in Owerri, Imo State, Nigeria, between September 2014 and February 2016.

Methodology: Physicochemical and microbiological analyses were carried out on three abattoir effluents and their receiving water bodies. Counts of total heterotrophic bacteria, total coliform and faecal coliform, Vibrio, Salmonella and Shigella were carried using the plate count method.

Results: The bacterial isolates in the various samples included members of the genera Bacillus, Citrobacter, Enterobacter, Escherichia, Klebsiella, Lactobacillus, Listeria, Micrococcus, Proteus, Salmonella, Serratia, Staphylococcus, Streptococcus and Vibrio. The order of increasing effluent’s total coliform and faecal counts within the different abattoirs are given as Egbu abattoir > Amakohia Ikeduru abattoir > Ahiara abattoir. For the receiving streams, the order was as follows, for the total coliform count: Egbu abattoir > Ahiara abattoir > Amakohia Ikeduru abattoir while for faecal coliform: Egbu abattoir > Amakohia Ikeduru abattoir > Ahiara abattoir. About 85.7% and 42.9% of the total bacterial isolates were found in the Egbu abattoir effluent and receiving the stream, respectively. Ahiara abattoir’s effluent had 66.7% of the bacteria while its receiving stream had 23.8%. Over 57% of the total bacterial isolates were distributed in the Amakohia Ikeduru abattoir with 33.3% for its receiving stream.

Conclusion: This study revealed that pathogenic bacteria from abattoir were constantly discharged into receiving streams, thereby presenting serious health risks. The health status of residents of Owerri who have access to these water bodies should be studied to determine the health implications of such unregulated practices.
Implanting Atomic Cobalt within Mesoporous Carbon toward Highly Stable Lithium–Sulfur Batteries
Authors: Xie Jin , Li Bo‐Quan , Peng Hong‐Jie , Song Yun‐Wei , Zhao Meng , Chen Xiao , Zhang Qiang , Huang Jia‐Qi
Published: September 2019

Lithium–sulfur (Li–S) batteries hold great promise to serve as next‐generation energy storage devices. However, the practical performances of Li–S batteries are severely limited by the sulfur cathode regarding its low conductivity, huge volume change, and the polysulfide shuttle effect. The first two issues have been well addressed by introducing mesoporous carbon hosts to the sulfur cathode. Unfortunately, the nonpolar nature of carbon materials renders poor affinity to polar polysulfides, leaving the shuttling issue unaddressed. In this contribution, atomic cobalt is implanted within the skeleton of mesoporous carbon via a supramolecular self‐templating strategy, which simultaneously improves the interaction with polysulfides and maintains the mesoporous structure. Moreover, the atomic cobalt dopants serve as active sites to improve the kinetics of the sulfur redox reactions. With the atomic‐cobalt‐decorated mesoporous carbon host, a high capacity of 1130 mAh gS−1 at 0.5 C and a high stability with a retention of 74.1% after 300 cycles are realized. Implanting atomic metal in mesoporous carbon demonstrates a feasible strategy to endow nanomaterials with targeted functions for Li–S batteries and broad applications.
Rational Tuning of Molecular Interaction and Energy Level Alignment Enables High‐Performance Organic Photovoltaics
Authors: Wang Rui , Yuan Jun , Wang Rui , Han Guangchao , Huang Tianyi , Huang Wenchao , Xue Jingjing , Wang Hao‐Cheng , Zhang Chunfeng , Zhu Chenhui , Cheng Pei , Meng Dong , Yi Yuanping , Wei Kung‐Hwa , Zou Yingping , Yang Yang
Published: September 2019

The performance of organic photovoltaics (OPVs) has rapidly improved over the past years. Recent work in material design has primarily focused on developing near‐infrared nonfullerene acceptors with broadening absorption that pair with commercialized donor polymers; in the meanwhile, the influence of the morphology of the blend film and the energy level alignment on the efficiency of charge separation needs to be synthetically considered. Herein, the selection rule of the donor/acceptor blend is demonstrated by rationally considering the molecular interaction and energy level alignment, and highly efficient OPV devices using both‐fluorinated or both‐nonfluorinated donor/acceptor blends are realized. With the enlarged absorption, ideal morphology, and efficient charge transfer, the devices based on the PBDB‐T‐F/Y1‐4F blend and PBDB‐T‐F/Y6 exhibit champion power conversion efficiencies as high as 14.8% and 15.9%, respectively.
A Flexible Strain Sensor of Ba(Ti, Nb)O3/Mica with a Broad Working Temperature Range
Authors: Yang Cheng , Guo Min , Gao Dong , He Waner , Feng Jiajun , Zhang Aihua , Fan Zhen , Chen Deyang , Zeng Min , Wu Sujuan , Gao Jinwei , Guo Chuan Fei , Zhou Guofu , Lu Xubing , Liu Junming
Published: September 2019

Flexible strain sensors have captured a lot of attention since first being proposed. Most studies are focused on adopting new materials or developing novel structures to detect strain, temperature, and even to realize multifunction. The reliability of flexible strain sensors in harsh environments such as at low and high temperatures, however, has so far received little attention because traditional bendable or stretchable substrates, including polyethylene terephthalate, polyimide, polydimethylsiloxane, paper, silk, and cotton, cannot withstand high temperature. The poor thermostability limits their potential applications in harsh conditions such as in interstellar probes, polar exploration, petrochemical, and metal smelting. Here, a heat‐resisting flexible strain sensor is shown, consists of a BaNb0.5Ti0.5O3 film on top of a 4.5 µm thick mica substrate. The device exhibits excellent thermal stability in a wide temperature range from 20 to 773.15 K. Owing to the ultrathin mica substrate and low resistance, the device demonstrates low power consumption (0.96 µW cm−2), is lightweight (2.06 g cm−3), together with having high stability over 5000 bending cycles. This work opens a path for pressure sensors applying ceramic materials that can be used from an ultralow to a high temperature.
Millimeter‐Wave Digital Coding Metasurfaces Based on Nematic Liquid Crystals
Authors: Wang Qiang , Zhang Xin Ge , Tian Han Wei , Jiang Wei Xiang , Bao Di , Jiang Hao Lin , Luo Zhang Jie , Wu Li Ting , Cui Tie Jun
Published: September 2019

Metasurfaces provide an unprecedented capability in manipulating electromagnetic waves. In this work, a millimeter‐wave (mmW) digital coding metasurface based on nematic liquid crystals (NLCs) is proposed and realized. By tuning the bias voltage loaded on the NLCs, the effective permittivity of the NLCs substrate is changed, thus providing different reflection phases. As a proof of concept, mmW beam splitting and mmW beam steering at mmW frequencies are demonstrated using a single metasurface platform. The experimental results are in good agreement with numerical simulations. The proposed digital coding metasurfaces have promising applications on planar mmW devices, such as multi‐beam antennas, beam‐scanning antennas, and wave controllers.
Dynamic Color‐Switching of Plasmonic Nanoparticle Films
Authors: Liu Luntao , Aleisa Rashed , Zhang Yun , Feng Ji , Zheng Yiqun , Yin Yadong , Wang Wenshou
Published: September 2019

The fast and reversible switching of plasmonic color holds great promise for many applications, while its realization has been mainly limited to solution phases, achieving solid‐state plasmonic color‐switching has remained a significant challenge owing to the lack of strategies in dynamically controlling the nanoparticle separation and their plasmonic coupling. Herein, we report a novel strategy to fabricate plasmonic color‐switchable silver nanoparticle (AgNP) films. Using poly(acrylic acid) (PAA) as the capping ligand and sodium borate as the salt, the borate hydrolyzes rapidly in response to moisture and produces OH− ions, which subsequently deprotonate the PAA on AgNPs, change the surface charge, and enable reversible tuning of the plasmonic coupling among adjacent AgNPs to exhibit plasmonic color‐switching. Such plasmonic films can be printed as high‐resolution invisible patterns, which can be readily revealed with high contrast by exposure to trace amounts of water vapor.
Hoarding: A multifactorial understanding
Authors: Akhtar Salman
Published: September 2019

The syndrome of hoarding has remained largely unaddressed by psychoanalysts. This is because grotesque forms of it do not appear at the clinician's door and the public focus on such gross pathology draws attention away from the subtler forms of hoarding in our patients. This paper delineates a thorough phenomenological profile of the hoarding disorder, distinguishing it from collecting and from obsessive–compulsive disorder with which it is frequently confused. It traces the phylogenetic basis of hoarding to animal survival techniques, the sociogenetic basis of the producers' induction of false needs in consumers, and ontogenetic basis to object‐hunger consequent upon childhood loss. The paper recommends a large‐hearted differential therapeutics to help individuals suffering from this syndrome.
Design and in silico modeling of Indoloquinoxaline incorporated keratin nanoparticles for modulation of glucose metabolism in 3T3‐L1 adipocytes
Authors: Kunjiappan Selvaraj , Theivendren Panneerselvam , Pavadai Parasuraman , Govindaraj Saravanan , Sankaranarayanan Murugesan , Somasundaram Balasubramanian , Arunachalam Sankarganesh , Ram Kumar Pandian Sureshbabu , Ammunje Damodar Nayak
Published: September 2019

The following study was done to assess the glucose utilizing efficiency of Indoloquinoxaline derivative incorporated keratin nanoparticles (NPs) in 3T3‐L1 adipocytes. Indoloquinoxaline derivative had wide range of biological activities including antidiabetic activity. In this view, Indoloquinoxaline moiety containing N, N‐dimethyl (3‐fluoro‐6H‐indolo [3,2‐b] quinoxalin‐6‐yl) methanamine compound was designed and synthesized, and further it is incorporated into keratin nanoparticles. The formulated NPs, drug entrapment efficiency, releasing capacity, stability, and physicochemical properties were characterized by various spectral analyzer and obtained results of characterizations were confirmed the properties of NPs. The analysis of mechanism underlying the glucose utilization of NPs was examined through molecular docking with identified target, and observed in silico study reports shown strong interaction of NPs in the binding pockets of AMPK and PTP1B. Based on the in silico screening, the formulated NPs was performed for in vitro cellular viability and glucose uptake studies on 3T3‐L1 adipocytes. Interestingly, 40 μg of NPs displayed 78.2 ± 2.76% cellular viability, and no cell death was observed at lower concentrations. Further, the concentration dependent glucose utilization was observed at different concentrations of NPs in 3T3‐L1 adipocytes. The results of NPs (40 μg) on glucose utilization have revealed eminent result 58.56 ± 4.54% compared to that of Metformin (10 μM) and Insulin (10 μM). The identified results clearly indicated that Indoloquinoxaline derivative incorporated keratin NPs significantly increased glucose utilization efficiency and protect the cells against the insulin resistance.
Reflecting on Maltese school‐based counselling practices: An autoethnographic collaborative writing project
Authors: Falzon Ruth , Galea Carmen , Galea Rita , Galea Silvia , Muscat Maud
Published: September 2019

Maltese counsellors working in schools are, at times, just making ends meet due to lack of human resources and work schedules. ‘Why do our students/children have to repeat the same story to so many professionals?’ teachers/parents angrily query. This autoethnographic study voices our professional experiences as authors and participants. This empowers us to be advocates for our young clients. Collaborative autoethnography (CAE) methodology best fits our research question as we ‘seek to discover and systemically analyze (graphy) personal experience (auto)…understand cultural experience (ethno)’ (Ellis, Adams, & Brochner, 2011, p. 273). Our writing and reflections conclude that best practices include counsellors who work, at least, in pairs within transdisciplinary teams at one school for cycles of five years, with clarity of roles across professionals.
The protective effects of grape seed procyanidin B2 against asporin mediates glycated low‐density lipoprotein induced‐cardiomyocyte apoptosis and fibrosis
Authors: Li Xiao‐Li , Yu Fei , Li Bao‐Ying , Fu Chun‐Li , Yu Xin , Xu Mei , Cheng Mei , Gao Hai‐Qing
Published: September 2019

The progression of diabetic cardiomyopathy is related to cardiomyocyte dysfunction and apoptosis. Our previous studies showed that asporin (ASPN) was significantly increased in the myocardium of db/db mice through proteomics, and grape seed procyanidin B2 (GSPB2) significantly inhibited the expression of ASPN in the heart of db/db mice. We report here that ASPN played a critical role in glycated low‐density lipoproteins (gly‐LDL) induced‐cardiomyocyte apoptosis. We found that gly‐LDL upregulated ASPN expression. ASPN increased H9C2 cardiomyocyte apoptosis with down‐regulation of Bcl‐2, upregulation of transforming growth factor‐β1, Bax, collagen III, fibronectin, and phosphorylation of smad2 and smad3. However, GSPB2 treatment reversed ASPN‐induced impairments in H9C2 cardiomyocytes. These results provide evidence for the cardioprotective action of GSPB2 against ASPN injury, and thus suggest a new target for fighting against diabetic cardiomyopathy.
Contemporary management of stent thrombosis: Predictors of mortality and the role of new‐generation drug‐eluting stents
Authors: Katsikis Athanasios , Keeble Thomas R. , Davies John R. , Jagathesan Rohan , Kabir Alamgir , Sayer Jeremy W. , Robinson Nicholas M. , Kalogeropoulos Andreas S. , Aggarwal Rajesh K. , Gamma Reto A. , Tang Kare H. , Kassimis George , Kelly Paul A. , Clesham Gerald J. , Karamasis Grigoris V.
Published: September 2019

Objectives

We sought to evaluate mortality predictors and the role of new‐generation drug‐eluting stents (NG‐DES) in stent thrombosis (ST) management.

Background

No data are available regarding the outcome of patients with ST after interventional management that includes exclusively NG‐DES.

Methods

Patients with definite ST of DES or BMS who underwent urgent/emergent angiography between 2015 and 2018 at our institution were considered for the study. After excluding patients who achieved TIMI‐flow<2 after intervention or received an old‐generation stent, 131 patients were included. Management classification was stent or non‐stent treatment (medical management, thromboaspiration, balloon‐angioplasty). Follow‐up was performed to document all‐cause death (ACD) and target‐lesion‐revascularization (TLR) that was used for censorship.

Results

Mode of presentation was STEMI in 88% and UA/NSTEMI in 12%. Type of ST was early, late, and very late in 11, 4, and 85%, respectively. Eighty four patients received stent and 47 non‐stent treatment. After 926 ± 34 days, 21 ACDs, 7 TLRs and no cases of definite, recurrent ST were observed. Univariate predictors of in‐hospital mortality were LVEF and presentation with shock or cardiac arrest. For patients discharged alive, non‐stent treatment (HR 4.2, p = .01), TIMI‐2 flow (HR 7.4, p = .002) and GFR < 60 mL/min (HR 3.8, p = .01) were independent predictors of ACD. The stent‐treatment group had significantly better ACD‐free survival after discharge, both unadjusted (p = .022) and adjusted (p = .018).

Conclusions

After ST management, different predictors were observed for in‐hospital mortality and mortality in patients discharged alive. The better outcome with NG‐DES treatment is a novel observation, warranting further studies to elucidate if it is associated with stent‐related or patient‐related factors.
S‐Scheme Heterojunction TiO2/CdS Nanocomposite Nanofiber as H2‐Production Photocatalyst
Authors: Ge Haonan , Xu Feiyan , Cheng Bei , Yu Jiaguo , Ho Wingkei
Published: September 2019

One‐dimensional (1D) nanostructured photocatalyst is a promising candidate for hydrogen (H2) generation, which can be used to deal with the energy crisis. Herein, novel 1D TiO2/CdS well‐hybridized nanofibers (NFs) were synthesized via in situ electrospinning method. These 1D hybrid NFs showed a high H2‐production rate of 2.32 mmol h−1 g−1 with an apparent quantum efficiency of 10.14 %, which was 35‐fold higher than that of pristine TiO2 NFs. X‐ray photoelectron spectroscopy (XPS) analysis and density functional theory calculation implied that the electrons transferred from CdS to TiO2 upon hybridization and created an internal electric field (IEF) pointing from CdS to TiO2. This IEF drove the photoexcited electrons in TiO2 to transfer toward CdS upon light irradiation as revealed by in situ irradiated XPS analysis, suggesting that a step‐scheme (S‐scheme) heterojunction was formed in the TiO2/CdS nanohybrids and greatly promoted the separation of electron‐hole pairs to foster efficient H2 photogeneration. The significant enhancement of photocatalytic activity was also benefited from the easy transfer for electrons in the 1D well‐distributed nanostructure of nanohybrids. This work presents a method for in situ preparing well‐distributed 1D NFs with high photocatalytic activity for H2 production via the S‐scheme pathways.
New Insights in Frustrated Lewis Pair Chemistry with Azides
Authors: Boom Devin H. A. , Jupp Andrew R. , Nieger Martin , Ehlers Andreas W. , Slootweg J. Chris
Published: September 2019

The geminal frustrated Lewis pair (FLP) tBu2PCH2BPh2 (1) reacts with phenyl‐, mesityl‐, and tert‐butyl azide affording, respectively, six, five, and four‐membered rings as isolable products. DFT calculations revealed that the formation of all products proceeds via the six‐membered ring structure, which is thermally stable with an N‐phenyl group, but rearranges when sterically more encumbered Mes−N3 and tBu−N3 are used. The reaction of 1 with Me3Si−N3 is believed to follow the same course, yet subsequent N2 elimination occurs to afford a four‐membered heterocycle (5), which can be considered as a formal FLP‐trimethylsilylnitrene adduct. Compound 5 reacts with hydrochloric acid or tetramethylammonium fluoride and showed frustrated Lewis pair reactivity towards phenylisocyanate.
Pyridyl‐Functionalized 1‐Phosphabarrelene: Synthesis, Coordination Chemistry and Photochemical di‐π‐Methane Rearrangement
Authors: Bruce Marlene , Papke Martin , Ehlers Andreas W. , Weber Manuela , Lentz Dieter , Mézailles Nicolas , Slootweg J. Chris , Müller Christian
Published: September 2019

The [4+2] cycloaddition of 2‐(2′‐pyridyl)‐4,6‐diphenyl‐λ3‐phosphinine with the highly reactive dienophile hexafluoro‐2‐butyne has been studied and the first pyridyl‐functionalized 1‐phosphabarrelene was obtained and structurally characterized. Although monodentate CF3‐1‐phosphabarrelenes show only a poor coordination ability, the chelating nature of the novel P,N‐hybrid ligand gives access to various transition‐metal complexes. Upon irradiation with UV light, the pyridyl‐functionalized 1‐phosphabarrelene undergoes a rather selective di‐π‐methane rearrangement in the coordination sphere of the metal center, leading to the formation of a complex based on a hitherto unknown pyridyl‐functionalized 5‐phosphasemibullvalene derivative. DFT calculations provide first insights into the mechanism of this reaction.
Understanding the Localization of Berylliosis: Interaction of Be2+ with Carbohydrates and Related Biomimetic Ligands
Authors: Müller Matthias , Buchner Magnus R.
Published: September 2019

The interplay of metal ions with polysaccharides is important for the immune recognition in the lung. Due to the localization of beryllium associated diseases to the lung, it is likely that beryllium carbohydrate complexes play a vital role for the development of berylliosis. Herein, we present a detailed study on the interaction of Be2+ ions with fructose and glucose as well as simpler biomimetic ligands, which emulate binding motives of saccharides. Through NMR and IR spectroscopy as well as single‐crystal X‐ray diffraction, complemented by competition reactions we were able to determine a distinctive trend in the binding affinity of these ligands. This suggests that under physiological conditions beryllium ions are only bound irreversibly in glycoproteins or polysaccharides if a quasi ideal tetrahedral environment and κ4‐coordination is provided by the respective biomolecule. Furthermore, Lewis acid induced conversions of the ligands and an extreme increase in the Brønstedt acidity of the present OH‐groups imply that upon enclosure of Be2+, alterations may be induced by the metal ion in glycoproteins or polysaccharides. In addition the frequent formation of Be‐O‐heterocycles indicates that multinuclear beryllium compounds might be the actual trigger of berylliosis. This investigation on beryllium coordination chemistry was supplemented by binding studies of selected biomimetic ligands with Al3+, Zn2+, Mg2+, and Li+, which revealed that none of these beryllium related ions was tetrahedrally coordinated under the give conditions. Therefore, studies on the metabolization of beryllium compounds cannot be performed with other hard cations as a substitute for the hazardous Be2+.
Oxidation of Enones for Regioselective [3+2] Cycloaddition through γ‐Enone Radical Intermediates
Authors: Kan Jian , Zhang Min , Zhang Xiaofeng , Lou Xin , Shang Yaping , Xu Biping , Yang Fanyuanhang , Su Weiping
Published: September 2019

Herein, an oxidization reaction of enones with a CuII complex that leads to a new type of regioselective [3+2] cycloaddition is reported. Highly functionalized cyclopentenes and spirocyclic compounds are obtained in moderate‐to‐good yields. This cycloaddition reaction occurred through the formation of γ‐enone radicals, providing a rarely explored reactivity pattern for enones.
Effect of Rotor Disc Diameter on Holdup, Axial Dispersion and Droplet Size in a Taylor‐Couette Disc Contactor
Authors: Grafschafter Annika , Siebenhofer Matthäus
Published: September 2019

Application of liquid‐liquid extraction is on a steady rise. Although there are considerable designs of extraction devices, equipment design and optimization is still on the research agenda. Utilization in the biorefinery industry or metallurgy requires robust technologies and equipment. The simple design and stable operation performance of the Taylor‐Couette disc contactor suffices the technical needs for these harsh operation conditions. The effect of different rotor disc diameter on the dispersed phase holdup, axial dispersion, and droplet size was investigated. It was shown that with smaller rotor disc diameter stable operation is still feasible but higher axial backmixing has to be expected.
Instandhaltung und Service als Wirtschaftsfaktor
Authors: Huonker Wolfram
Published: September 2019

Auf Wachstumskurs sieht der Wirtschaftsverband Industrieservice (WVIS) seine Branche. Das weitere Wachstum hängt nach dessen Einschätzung jedoch von Spezialisierung, ICT‐Kompetenz und zukunftsfähigen Personalstrategien ab. Orientierung will hierbei die In.Stand. am 23. und 24. Oktober geben und lädt Instandhalter und Servicefachleute auf das Stuttgarter Messegelände zur neuen Fachmesse für Instandhaltung und Services ein.
Gerade Kanten für schnelle Prozesse
Authors: Deck Nadine
Published: September 2019

Der Drang zur ständigen Verbesserung ist in manchen Unternehmen besonders ausgeprägt. Bei der Progroup etwa ist man allein durch den sehr dynamischen Verpackungsmarkt immer an Optimierungen im Produktionsprozess interessiert. In diesem Zusammenhang überzeugte auch der Vegapuls 64, der verglichen mit den riesigen Papiermaschinen zwar nur ein kleines, aber dennoch entscheidendes Rädchen im Gesamtprozess darstellt.
Schneller zum Ziel mit höherer Qualität
Authors: Kullmann Thomas
Published: September 2019

Anlagen in der Intralogistik werden immer größer und komplexer. Unvorhergesehene Probleme können den Inbetriebnahmeprozess ausbremsen oder komplexe Anlagenprozesse müssen immer wieder 〟durchgespielt〝 werden. Die Inbetriebnahme kann so schnell ausufern und letztendlich den Zeitrahmen und die Gesamtkosten eines Projektes erhöhen. Hier bringt eine virtuelle Inbetriebnahme mit einem Digitalen Zwilling der realen Anlage enorme Vorteile.
Prozesse schlanker, sicherer und schneller machen
Authors: Leisinger Nadine
Published: September 2019

Eine der zentralen Fragen für pharmazeutische Unternehmen ist: Wie können Pharmaanlagen trotz einer Vielzahl an prozesstechnischen Anforderungen möglichst wirtschaftlich und sicher geplant, gebaut und betrieben werden? Ein echtes Vorzeigeprojekt von Müller Processing ist ein Materialhandlingsystem für hochaktive Wirkstoffe, das im vergangenen Jahr beim Biotechspezialisten Alexion in Irland in Betrieb gegangen ist
Unbemannte Tankfahrt
Authors: Günther Sabine
Published: September 2019

Erstmals hat Lobbe in Kooperation mit ST‐Cleaning einen Roboter zur Tankreinigung im Werk Böhlen der Dow Olefinverbund eingesetzt. Wie eine unbemannte Raumfahrt startet an einem nebligen Novembermorgen die Reinigung eines 40.000 m3‐Tanks mittels Roboter
Sonderlösung für die Spezialchemie
Authors: Dylla Eike
Published: September 2019

Aufgrund von Modernisierungsarbeiten an Behältern in einem deutschen Chemiewerk war es notwendig eine temporäre Lösung zur übernahme eines leichtentzündliche Fluids zu schaffen. Für die übergangsphase wurden die Fördermengen reduziert, so dass die vorhandenen Pumpensysteme überdimensioniert waren und daher nicht eingesetzt werden konnten. Mit der hermetisch dichten Membrandosierpumpe aus der Ecodos‐Baureihe bot Lewa eine für die Förderung gefährlicher Stoffe sehr gut geeignete Pumpe an
Klassische Pumpenlösung für neuen Prozess
Authors: Höppener Roland
Published: September 2019

Korrosionsfeste Werkstoffe und langlebige Wellenabdichtungen: Das sind zwei wichtige Konstruktionsmerkmale der Pumpen, die künftig heiße Schwefelsäure bei Aurubis in Hamburg fördern. Mit der Abwärme, die bei der Herstellung dieser Schwefelsäure entsteht, versorgt Aurubis die östliche HafenCity mit CO2‐freier Wärme. Die Pumpen werden von dem Unternehmen Rheinhütte Pumpen geliefert, das eine lange Tradition bei der Entwicklung und Fertigung von Pumpen für korrosive Medien vorweisen kann
Scherarm pumpen
Authors: Willis Roger
Published: September 2019

Im neuen Werk für Synthesekautschuk eines indonesischen Herstellers kommen nur noch Nemo Exzenterschneckenpumpen von Netzsch Pumpen & Systeme zur Förderung des Trennmittels zum Einsatz, das ein Zusammenkleben frischer Kautschukbahnen verhindert
High prevalence of malnutrition and nutrition impact symptoms in older patients with cancer: Results of a Brazilian multicenter study
Authors: de Pinho Nivaldo B. , Martucci Renata B. , Rodrigues Viviane D. , D’Almeida Cristiane A. , Thuler Luiz C. S. , Saunders Claudia , Jager‐Wittenaar Harriet , Peres Wilza A. F.
Published: September 2019

Background

Malnutrition in cancer is an independent factor associated with negative clinical outcomes. The objective of this study was to evaluate the prevalence of malnutrition across different age groups in patients with cancer in Brazil and to identify associations with nutrition impact symptoms (NIS).

Methods

In this observational, cross‐sectional, multicenter study, the authors evaluated 4783 patients with cancer aged ≥20 years who were admitted to 45 public hospitals in Brazil. Nutritional status, nutritional risk, and NIS were evaluated using the Patient‐Generated Subjective Global Assessment.

Results

More than one‐fourth (25.5%) of all participants were aged ≥65 years. In patients aged ≥65 years, the prevalence of moderate/suspected and severe malnutrition was 55%, it was 45.4% in those aged 51 to 64 years, and it was 36.1% in those aged ≤50 years. Among the NIS with a higher risk of occurrence in patients aged ≥65 years were no appetite (odds ratio [OR], 1.90; 95% CI, 1.62‐2.22; P < .05) and dry mouth (OR, 1.40; 95% CI, 1.1‐1.67; P < .05). In patients between ages 51 and 64 years, compared with those aged ≤50 years, the NIS with a higher risk of occurrence were no appetite (OR, 1.45; 95% CI, 1.23‐1.69; P < .05), dry mouth (OR, 1.22; 95% CI, 1.02‐1.45; P < .05), and problems with swallowing (OR, 1.56; 95% CI, 1.25‐1.96; P < .05).

Conclusions

The prevalence of malnutrition and the occurrence of NIS are high in hospitalized Brazilian patients aged ≥65 years who have cancer. The occurrence of NIS was higher in the population aged >50 years than in those aged ≤50 years. Nutritional screening and assessment should be performed immediately after hospitalization to enable early diagnosis and multidisciplinary or interdisciplinary intervention(s).
The fundamental theorem of tristimulus integration
Authors: Fairman Hugh S.
Published: September 2019

The colorimetric operation of tristimulus integration is analyzed from first principles. An expression compatible with the tenets of linear algebra is found to describe this operation. This expression proves to be different from the operation prescribed by the Commission Internationale de l'Eclairage (CIE) for calculating tristimulus values. This article goes on to examine just what the CIE may be calculating, how their values may relate to tristimulus values, and how it may have occurred that no others have noticed this fact over more than 85 years of use of the CIE method.
Sustainability management emergence and integration on different management levels in smaller large‐sized companies in Austria
Authors: Kiesnere Aisma Linda , Baumgartner Rupert J.
Published: September 2019

Companies should integrate sustainability into all organizational units and on all management levels to contribute to sustainable development. This study explores nine smaller large‐sized companies (revenue between €50 and €300 million, at least 250 employees) from various sectors. We applied the framework of Baumgartner for corporate sustainability/corporate social responsibility empirically and used the promotor model of Witte from innovation management in the context of sustainability. The findings show that companies must have (a) top management support and (b) an open organizational culture regarding sustainable development to integrate sustainability on operational, strategic, and normative management levels. These two prerequisites need to remain stable over time, as changes in top management and staff create new challenges in sustainability implementation. The companies have mainly implemented sustainability management from the top‐down, first enlarging aspects of environmental management and human resource management and then integrating sustainability in terms of their vision and strategy. If top management does not see the need to alter the organization to address sustainability challenges, lower level managers or middle managers might take the initiative. In this case, however, only good environmental and human resources management practices are enabled. The top management blocks bottom‐up implementation efforts if they are not willing to make decisions based on new values and judgement and promote change in the organization. Our case studies show that a power promoter is essential for the integration of sustainability on all organizational levels. Presence of strong power promoter allows other promoter types to act in sustainability integration.
Water‐Tolerant Lead Halide Perovskite Nanocrystals as Efficient Photocatalysts for Visible‐Light‐Driven CO2 Reduction in Pure Water
Authors: Mu Yan‐Fei , Zhang Wen , Guo Xiao‐Xuan , Dong Guang‐Xing , Zhang Min , Lu Tong‐Bu
Published: September 2019

Lead halide perovskite (LHP) nanocrystals have recently been actively investigated for photocatalysis, owing to their inexpensive fabrication and excellent optoelectronic properties. However, LHP nanocrystals have not been used for artificial photosynthesis in aqueous solution, owing to their high sensitivity to water. In this study, water‐tolerant cobalt‐doped CsPbBr3/Cs4PbBr6 nanocrystals have been prepared with the protection of hexafluorobutyl methacrylate. The resultant materials are employed as efficient photocatalysts for visible‐light‐driven CO2 reduction in pure water. The perovskite nanocrystals with 2 % cobalt doping afford an impressive overall yield of 247 μmol g−1 for photocatalytic CO2 conversion into CO and CH4, using water as an electron source. This study represents a significant step for practical artificial photosynthesis by using LHP nanocrystals as photocatalysts in aqueous solution.