bluuebunny/crossref_metadata_2025 huggingface dataset:
Incarvillea compacta Maxim ameliorates inflammatory response via inhibiting PI3K/AKT pathway and NLRP3 activation
Authors: Zhang Ji , Feng Yujing , Han Shengqiang , Guan Xueting , He Ziliang , Song Chao , Lv Lingyun , Luo Qiaoyu
Published: October 2022

Incarvillea compacta Maxim is a traditional Tibetan medicine used to treat inflammation-related diseases, such as pneumonia, fever, jaundice, and otitis media. However, no studies have examined its anti-inflammatory mechanism. To validate the anti-inflammatory activity of I. compacta extract (ICE) and its protective effect on acute alcoholic gastritis, Phytochemicals of I. compacta were identified using Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Lipopolysaccharide (LPS)-induced RAW 264.7 macrophages were used in vitro along with an in vivo a mouse acute gastritis model. Pro-inflammatory mediators and cytokines were measured using the Griess reagent and Cytometric bead array (CBA) assay. Furthermore, inflammation-related molecules were analysed by Western blotting, RNA-Seq, and real-time quantitative PCR (RT-qPCR). The experimental results revealed that ICE decreased the nitric oxide (NO), IL-6, MCP-1, and TNF-α levels in LPS-stimulated RAW 264.7 cells, and downregulated the expression and phosphorylation of PDK1, AKT, and GSK3β. Moreover, ICE also downregulated the activation of NLRP3. The RNA-Seq analysis revealed that 340 differentially expressed genes (DEGs) response to ICE treatment was enriched in several inflammation-related biological processes. The results of the in vivo mouse acute gastritis model showed that ICE significantly reduced inflammatory lesions in the gastric mucosa and remarkably downregulated the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNA in gastric tissue. Therefore, the results of this study obtained scientific evidence supporting the use of I. compacta.
Dynamical behavior of a stochastic SICR rumor model incorporating media coverage
Authors: Yue Xuefeng , Huo Liangan
Published: October 2022

Rumor propagation in the new media era poses a huge threat to maintaining the normal order of social life. In this context, we put forth a nonlinear dynamics-based stochastic SICR rumor model that integrates media coverage with science education. First, the existence of a unique global positive solution is obtained. Second, sufficient conditions for extinction are constructed on the spread of rumors based on the Lyapunov function methods and Khasminskii’s theory. Finally, the theoretical analysis is verified through numerical simulations. Additionally, it demonstrates how rumor spreading can be hampered by media coverage.
The hydrogen bond rotation of confined water affected by quantum resonance tunnelling
Authors: Yang Xinrui , Jin Le , Zhu Yu , Zhang Zhiyuan , Liu Rui , Wang Zhigang
Published: October 2022

In this work, we report quantum tunnelling effects on the confined water chain flipping, different from the spatial size and even electronic correlation effects of the confinement environment. First-principles calculations and analyses confirm that quantum tunnelling from the water chain itself enhances the hydrogen bond rotation. Importantly, the neglected resonant tunnelling can result in tunnelling rotation of hydrogen bonds with a probability close to 1 through the provided 0.6 eV energy, while the probability of generally recognized sequential tunnelling is only 10−6. Not only that, compared to sequential tunnelling, resonant tunnelling leads to a 20 K higher flipping temperature of the water chain. Additionally, the ratio of the resonant tunnelling probability to the thermal disturbance probability at 200 K is at least ten times larger than that of sequential tunnelling, which further illustrates the enhancement of hydrogen bond rotation brought about by resonant tunnelling.
Cardiac ischemia modulates white adipose tissue in a depot-specific manner
Authors: Wang Luzhou , Zabri Heba , Gorressen Simone , Semmler Dominik , Hundhausen Christian , Fischer Jens W. , Bottermann Katharina
Published: October 2022

The incidence of heart failure after myocardial infarction (MI) remains high and the underlying causes are incompletely understood. The crosstalk between heart and adipose tissue and stimulated lipolysis has been identified as potential driver of heart failure. Lipolysis is also activated acutely in response to MI. However, the role in the post-ischemic remodeling process and the contribution of different depots of adipose tissue is unclear. Here, we employ a mouse model of 60 min cardiac ischemia and reperfusion (I/R) to monitor morphology, cellular infiltrates and gene expression of visceral and subcutaneous white adipose tissue depots (VAT and SAT) for up to 28 days post ischemia. We found that in SAT but not VAT, adipocyte size gradually decreased over the course of reperfusion and that these changes were associated with upregulation of UCP1 protein, indicating white adipocyte conversion to the so-called ‘brown-in-white’ phenotype. While this phenomenon is generally associated with beneficial metabolic consequences, its role in the context of MI is unknown. We further measured decreased lipogenesis in SAT together with enhanced infiltration of MAC-2+ macrophages. Finally, quantitative PCR analysis revealed transient downregulation of the adipokines adiponectin, leptin and resistin in SAT. While adiponectin and leptin have been shown to be cardioprotective, the role of resistin after MI needs further investigation. Importantly, all significant changes were identified in SAT, while VAT was largely unaffected by MI. We conclude that targeted interference with lipolysis in SAT may be a promising approach to promote cardiac healing after ischemia.
Exposure to strong irradiance exacerbates photoinhibition and suppresses N resorption during leaf senescence in shade-grown seedlings of fullmoon maple (Acer japonicum)
Authors: Kitao Mitsutoshi , Yazaki Kenichi , Tobita Hiroyuki , Agathokleous Evgenios , Kishimoto Junko , Takabayashi Atsushi , Tanaka Ryouichi
Published: October 2022

Leaves of fullmoon maple (Acer japonicum) turn brilliant red with anthocyanins synthesis in autumn. Based on field observations, autumn coloring mainly occurs in outer-canopy leaves exposed to sun, whereas inner-canopy leaves remain green for a certain longer period before finally turn yellowish red with a smaller amount of anthocyanins. Here, we hypothesized that outer-canopy leaves protect themselves against photooxidative stress via anthocyanins while simultaneously shading inner canopy leaves and protecting them from strong light (holocanopy hypothesis). To test this hypothesis, we investigated photoinhibition and leaf N content during autumn senescence in leaves of pot-grown seedlings of fullmoon maple either raised under shade (L0, ≈13% relative irradiance to open) or transferred to full sunlight conditions on 5th (LH1), 12th (LH2), or 18th (LH3) Oct, 2021. Dry mass-based leaf N (Nmass) in green leaves in shade-grown seedlings was ≈ 30 mg N g-1 in summer. Nmass in shed leaves (25th Oct to 1st Nov) was 11.1, 12.0, 14.6, and 10.1 mg N g-1 in L0, LH1, LH2, and LH3 conditions, respectively. Higher Nmass was observed in shed leaves in LH2, compared to other experimental conditions, suggesting an incomplete N resorption in LH2. Fv/Fm after an overnight dark-adaptation, measured on 19th Oct when leaf N was actively resorbed, ranked L0: 0.72 > LH3: 0.56 > LH1: 0.45 > LH2: 0.25. As decreased Fv/Fm indicates photoinhibition, leaves in LH2 condition suffered the most severe photoinhibition. Leaf soluble sugar content decreased, but protein carbonylation increased with decreasing Fv/Fm across shade-grown seedlings (L0, LH1, LH2, and LH3) on 19th Oct, suggesting impaired photosynthetic carbon gain and possible membrane peroxidation induced by photooxidative stress, especially in LH2 condition with less N resorption efficiency. Although the impairment of N resorption seems to depend on the timing and intensity of strong light exposure, air temperature, and consequently the degree of photoinhibition, the photoprotective role of anthocyanins in outer-canopy leaves of fullmoon maple might also contribute to allow a safe N resorption in inner-canopy leaves by prolonged shading.
Deciphering the core seed endo-bacteriome of the highland barley in Tibet plateau
Authors: Hao Zhao , Wang Yanhong , Guo Xiaofang , De Ji
Published: October 2022

Highland barley (Hordeum vulgare var. nudum (L.) Hook.f., qingke) has unique physical and chemical properties and good potential for industrial applications. As the only crop that can be grown at high altitudes of 4200–4500 m, qingke is well adapted to extreme habitats at high altitudes. In this study, we analysed the seed bacterial community of 58 genotypes of qingke grown in different regions of Tibet, including qingke landraces, modern cultivars, and winter barley varieties, and characterised endophytic bacterial communities in seeds from different sources and the core endo-bacteriome of qingke. This study aim to provide a reference for the application of seed endophytes as biological inoculants for sustainable agricultural production and for considering microbe-plant interactions in breeding strategies. A total of 174 qingke seed samples from five main agricultural regions in Tibet were collected and subjected to investigation of endophytic endo-bacteriome using high-throughput sequencing and bioinformatics approaches. The phyla of endophytic bacteria in qingke seeds from different sources were similar; however, the relative proportions of each phylum were different. Different environmental conditions, growth strategies, and modern breeding processes have significantly changed the community structure of endophytic bacteria in seeds, among which the growth strategy has a greater impact on the diversity of endophytic bacteria in seeds. Seeds from different sources have conserved beneficial core endo-bacteriome. The core endo-bacteriome of qingke seeds dominated by Enterobacteriaceae may maintain qingke growth by promoting plant growth and assisting plants in resisting pests and diseases. This study reveals the core endo-bacteriome of qingke seeds and provides a basis for exploiting the endophytic endo-bacteriome of qingke seeds.
Congruence in leaders-subordinates’ mindfulness and knowledge hiding: The role of emotional exhaustion and gender similarity
Authors: Wan Jun , Liu Zhengqiao , Zhang Xianchun , Liu Xiliang
Published: October 2022

Many scholars have focused on understanding ways of how to suppress knowledge hiding by employees. Existing studies have demonstrated that mindfulness could effectively inhibit employees’ knowledge hiding. This study aims to investigate the impact of leader–subordinate mindfulness congruence on subordinate knowledge hiding and its internal mechanisms. Based on the role theory, we collected 169 leadership data and 368 employee data at three time-points through collecting questionnaire of matching leaders and subordinates. In addition, we used polynomial regression and response surface analysis to validate our research hypotheses. The results demonstrated that: (i) Compared with the “high leader–high subordinate” mindfulness congruence condition, subordinates in the “low leader–low subordinate” mindfulness congruence condition were more likely to exhibit knowledge hiding. (ii) Compared with the “low leader–high subordinate” mindfulness incongruence, subordinates under the “high leader–low subordinate” mindfulness incongruence are more likely to exhibit knowledge hiding. (iii) The more incongruent the mindfulness between the leader and the subordinate is, the more likely an employee is to exhibit knowledge hiding. (iv) Emotional exhaustion mediated the correlation between leader–subordinate mindfulness congruence and knowledge hiding. (v) When the gender of the leader and the subordinate is different, the impact of mindfulness congruence on the inhibition of emotional exhaustion is stronger. This study provides a new perspective for researching the impact of mindfulness on individual behavior and provides a new idea for the research related to inhibiting knowledge hiding.
Relations among perceived stress, fatigue, and sleepiness, and their effects on the ambulatory arterial stiffness index in medical staff: A cross-sectional study
Authors: Lang Xiaorong , Wang Quan , Huang Sufang , Feng Danni , Ding Fengfei , Wang Wei
Published: October 2022

Objective

To explore the relations among perceived stress, fatigue, sleepiness, and the pathway of their effects on the ambulatory arterial stiffness index (AASI) among medical staff.

Methods

This cross-sectional study was conducted at a tertiary hospital in Wuhan, China. Perceived stress, fatigue, and sleepiness were measured using the perceived stress scale (PSS), Fatigue assessment scale (FAS), and Epworth Sleepiness Scale (ESS), respectively. AASI was obtained from 24-h ambulatory blood pressure monitoring. Path analysis was used to clarify the relations among the PSS, FAS, and ESS scores, and their relations to AASI values.

Results

A total of 153 participants were included herein. The PSS and FAS correlated with the ESS (r = 0.424, p < 0.001), and the PSS correlated with the FAS (r = 0.614, p < 0.001). In addition, the ESS correlated with the AASI (r = 0.225, p = 0.005). According to the path analysis results, the PSS and FAS had no direct effect on the AASI, but did have an indirect effect on this index (β = 0.059, 95% confidence interval [CI] = 0.017–0.128, p = 0.005; β = 0.059, 95%CI = 0.016–0.135, p = 0.006, respectively) by influencing the ESS (β = 0.263, β = 0.262, p = 0.004).

Conclusion

Sleepiness was a mediator of the effects of perceived stress and fatigue on AASI.
Path to posttraumatic growth: The role of centrality of event, deliberate and intrusive rumination, and self blame in women victims and survivors of intimate partner violence
Authors: Bakaitytė Aistė , Puente-Martínez Alicia , Ubilos-Landa Silvia , Žukauskienė Rita
Published: October 2022

Increased interest in positive changes in the aftermath of traumatic events led researchers to examine assumptions about the process of posttraumatic growth (PTG). However, existing studies often use samples from mixed trauma survivors and investigate separate factors and their associations with growth. Therefore, the purpose of the current study was to examine the path from centrality of event to PTG involving intrusive and deliberate rumination and self-blame as a coping strategy in women survivors of intimate partner violence (IPV). The study sample consisted of 200 women with a history of IPV (ages 18–69, M = 44.79, SD = 12.94). Results of the path analysis indicated that higher centrality of event was related to higher levels of intrusive rumination which was positively related to self-blame and deliberate rumination eventually leading to PTG. Indirect effects from centrality of event to PTG through intrusive and deliberate rumination, and from intrusive to deliberate rumination through self-blame were examined. This study gave support to some theoretical assumptions of the process of PTG and pointed out problematic areas of investigation of coping strategies in this process.
Innate ability, health, motivation, and social capital as predictors of students’ cognitive, affective and psychomotor learning outcomes in secondary schools
Authors: Owan Valentine Joseph , Ekpenyong John Asuquo , Chuktu Onyinye , Asuquo Michael Ekpenyong , Ogar Joseph Ojishe , Owan Mercy Valentine , Okon Sylvia
Published: October 2022

Background

Previous studies assessing students’ learning outcomes and identifying contributing factors have often dwelt on the cognitive domain. Furthermore, school evaluation decisions are often made using scores from cognitive-based tests to rank students. This practice often skews evaluation results, given that education aims to improve the three learning domains. This study addresses this gap by assessing the contributions of four students’ input to their cognitive, affective and psychomotor skills (CAPs).

Methods

A cross-section of senior secondary class II students (n = 870), sampled through the multistage procedure, participated in a physical survey. Students’ Inputs Questionnaire (STIQ) and Learning Outcomes Questionnaire (LOQ) were used for data collection. Based on data obtained from a pilot sample (n = 412), principal axis factoring (PAF) was performed to assess the internal structure of the instruments following an oblique rotation. The KMO value of sampling adequacy were 0.88 and 0.94, while the Bartlett’s test of sphericity were significant χ2(253) = 5,010; p < 0.001 and χ2(105) = 3693.38, p < 0.001 for the STIQ and LOQ, respectively. Confirmatory factor analysis was used to assess the models’ acceptability based on the maximum likelihood estimation technique. The main study used hierarchical linear regression for data analysis.

Results

Findings indicated that innate ability, health, motivation and social capital relatively and cumulatively predicted students’ overall, cognitive, affective and psychomotor learning outcomes. The proportion of variance explained by the predictors increased at different levels of the models with the addition of new variables. Students’ social capital reduced the effect of students’ innate ability regardless of their motivation and health status.

Conclusion/implication

This study has provided evidence that the four students’ inputs are crucial predictors of their learning outcomes in the three domains. This result is helpful for school management to provide services aimed at improving the school climate for students’ motivation and social capital. The result can provide policymakers with a proper understanding of the constituents of learning outcomes and how policies can be aligned to secure quality student inputs for maximum productivity in education.
Rejection sensitivity mediates the interparental conflict and adolescent Internet addiction: School connectedness as a moderator
Authors: Tao Zhiyuan , Zhao Xiuli , Wang Zhenhai , Yu Chengfu , Zhang Wei
Published: October 2022

Internet addiction (IA) is a growing social problem with negative mental and social outcomes; the present study examined whether rejection sensitivity mediates the relationship between interparental conflict and adolescent IA and the moderating role of school connectedness. One thousand and seven adolescents (51.84% females; Meanage = 13.17; SD = 0.69) anonymously completed questionnaires to assess interparental conflict, school connectedness, rejection sensitivity, IA, and demographic information. The model results showed that: (1) the positive association between interparental conflict and adolescent IA was partially mediated by rejection sensitivity; (2) this indirect link was moderated by the school connectedness and was stronger for adolescents with high school connectedness. The results provide support for the attachment theory that high interparental conflict could increase adolescents’ rejection sensitivity, and high school connectedness plays a double-edged role that adolescents show more rejection sensitivity while reporting high interparental conflict and high school connectedness.
Stakeholder relationships and corporate social goal orientation: Implications for entrepreneurial psychology
Authors: Lu Xiaowei , Sheng Ya , Xiao Yao , Wang Wei
Published: October 2022

As the sensitivity to corporate social responsibility (CSR) continues to grow, the goal of enterprises has expanded beyond the sole pursuit of economic value. Corporate social goal orientation has therefore come to occupy a central position in entrepreneurs’ psychology and the transition away from a market-only economy. This study uses secondary data from 4,288 samples of 725 Chinese-listed companies from 2009 to 2020 to explore the driving factors in social goal orientation based on the characteristics of sample companies and their industry groups from the perspective of stakeholder relationships. The results can be summarized as follows: (1) there is an inverted U-shaped relationship between government stakeholder relationships and social goal orientation, and there is a significant positive relationship between financial stakeholder relationships, market stakeholder relationships, and corporate social goal orientation. (2) The correlation between single-dual stakeholder relationships and social goal orientation is not consistent. In light of the nature of the roles of government and the market, the correlation between the government–market dual relationship and corporate social goal orientation is not significant. However, there is a significant correlation between the finance–government dual stakeholder relationship and social goal orientation; that is, the dual stakeholder relationship maintains the existence of non-institutional capital and corporate financial capital. Moreover, there is no significant correlation between the market–finance dual relationship and corporate social goal orientation, and there is substitutability between market and financial stakeholder relationships. With the deepening of our understanding of CSR, the core goal of enterprises is no longer confined to the pursuit of economic value, and their social goal orientation has come to be regarded as a major driving force in sustainable development. This study enriches the research on the relationship between stakeholder relationships and shows that stakeholder relationships also have important significance to both achieving corporate goals and shaping entrepreneurs’ psychology.
A comparison of perceptual anticipation in combat sports between experts and non-experts: A systematic review and meta-analysis
Authors: Zhang Zhen , Piras Alessandro , Chen Chao , Kong Bin , Wang Dexin
Published: October 2022

In order to systematically evaluate perceptual anticipation between experts and non-experts for different kinds of combat sports, we needed to perform a comprehensive assessment. In this systematic review and meta-analysis, we searched four English-language and three Chinese-language databases that used expert/non-expert research paradigms, to explore perceptual anticipation in combat sports. We employed a random effects model for pooled analyses using the inverse variance method. We included 27 eligible studies involving 233 datasets in this meta-analysis. We observed large effect sizes for the differences between experts and non-experts in both response accuracy (1.51; 95% CI: 1.15 to 1.87, p < 0.05) and reaction time (-0.91; 95% CI: −1.08 to−0.73, p < 0.05). We also observed substantial differences between experts and non-experts in the mean duration of visual fixations per trial (1.51; 95% CI: −2.40 to −0.63, p < 0.05), but not in the visual fixation duration (0.16; −061 to 0.92, p = 0.69). Taken together, high-level combat athletes have more advantages in perceptual anticipation than lower-level athletes, showing faster and more accurate responses when facing the opponent's attacks, as well as focusing on fewer points of visual fixations than novice athletes. Different types of combat sports and stimulus presentations affect perceptual anticipation abilities to varying extents in relation to outcome measures, with more pronounced expertise in a stimulus that is closer to real-world situations.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021226343, PROSPERO CRD42021226343.
Virtual Reality Animal Rescue World: Pediatric virtual reality analgesia during just noticeable pressure pain in children aged 2–10 years old (crossover design)
Authors: Alrimy Taima , Alhalabi Wadee , Malibari Areej A. , Alzahrani Fatma Salih , Alrajhi Sharifah , Alhalabi Mohammed , Hoffman Hunter G.
Published: October 2022

Background and aims

Excessive pain during medical procedures is a worldwide medical problem. Most scald burns occur in children under 6, who are often undermedicated. Adjunctive Virtual Reality (VR) distraction has been shown to reduce pain in children aged 6–17, but little is known about VR analgesia in young children. This study tests whether desktop VR (VR Animal Rescue World) can reduce the just noticeable pressure pain of children aged 2–10.

Methods

A within-subject repeated measures design was used. With treatment order randomized, each healthy volunteer pediatric participant underwent brief cutaneous pressure stimuli under three conditions: (1) no distraction, (2) a verbal color naming task (no VR), and (3) a large TV-based desktop VR distraction. A hand-held Wagner pressure pain stimulation device was used to generate just noticeable pain sensations. Participants indicated when a steadily increasing non-painful pressure stimulus first turned into a painful pressure sensation (just noticeable pain).

Results

A total of 40 healthy children participated (43% aged 2–5 years; and 57% aged 6–10 years). Compared to the no distraction condition, the 40 children showed significant VR analgesia (i.e., a significant reduction in pain sensitivity during the VR Animal Rescue World condition), t(39) = 9.83, p < 0.001, SD = 6.24. VR was also significantly more effective at reducing pain sensitivity vs. an auditory color naming task, t(39) = 5.42, p < 0.001, SD = 5.94. The subset of children aged 2–5 showed significant reductions in pain during VR. Children under 6 showed greater sensitivity to pain during no distraction than children aged 6–10.

Conclusion

During no distraction, children under 6 years old were significantly more sensitive to pain than children aged 6–10. Virtual reality (VR) significantly reduced the “just noticeable” pressure pain sensitivity of children in both age groups.
Online neurostimulation of Broca’s area does not interfere with syntactic predictions: A combined TMS-EEG approach to basic linguistic combination
Authors: Maran Matteo , Numssen Ole , Hartwigsen Gesa , Zaccarella Emiliano
Published: October 2022

Categorical predictions have been proposed as the key mechanism supporting the fast pace of syntactic composition in language. Accordingly, grammar-based expectations are formed—e.g., the determiner “a” triggers the prediction for a noun—and facilitate the analysis of incoming syntactic information, which is then checked against a single or few other word categories. Previous functional neuroimaging studies point towards Broca’s area in the left inferior frontal gyrus (IFG) as one fundamental cortical region involved in categorical prediction during incremental language processing. Causal evidence for this hypothesis is however still missing. In this study, we combined Electroencephalography (EEG) and Transcranial Magnetic Stimulation (TMS) to test whether Broca’s area is functionally relevant in predictive mechanisms for language. We transiently perturbed Broca’s area during the first word in a two-word construction, while simultaneously measuring the Event-Related Potential (ERP) correlates of syntactic composition. We reasoned that if Broca’s area is involved in predictive mechanisms for syntax, disruptive TMS during the first word would mitigate the difference in the ERP responses for predicted and unpredicted categories in basic two-word constructions. Contrary to this hypothesis, perturbation of Broca’s area at the predictive stage did not affect the ERP correlates of basic composition. The correlation strength between the electrical field induced by TMS and the ERP responses further confirmed this pattern. We discuss the present results considering an alternative account of the role of Broca’s area in syntactic composition, namely the bottom-up integration of words into constituents, and of compensatory mechanisms within the language predictive network.
Prevalence of psychopathy in a community sample of Spanish adults: Definitions and measurements matter
Authors: Sanz-García Ana , Peña Fernández María Elena , García-Vera María Paz , Sanz Jesús
Published: October 2022

The main objective of this work is to examine the prevalence of psychopathy in the general adult population from the main currently existing theoretical perspectives of psychopathy, using for this purpose the five-factor or Big Five model as a common language that allows the comparison and integration of the personality traits considered as defining psychopathy by these different perspectives. The NEO Personality Inventory-Revised (NEO PI-R) was applied to a sample of 682 adults of the general Spanish population. The prevalence of clinical and subclinical psychopathy was calculated according to six different definitions of these two constructs based on Hare’s, Lilienfeld’s, triarchic, and DSM-5-hybrid models, and the simultaneous presence of a minimum number of personality traits that differed from the sample mean by one standard deviation. Prevalence rates for the different definitions were consistently low, indicating that the prevalence of clinical psychopathy in the general Spanish population is around 0.55%, and that of subclinical psychopathy is around 1.65%. There were no significant sex differences in the prevalence of psychopathy. These results question the alarmist claims that warn about the existence in society of a very high number of people with psychopathy who can cause many social, economic, physical, and psychological damage to others.
Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence
Authors: Zhang Guang-Ming , Wu Hong-Yun , Cui Wen-Qiang , Peng Wei
Published: October 2022

Despite extensive research in recent decades, knowledge of the pathophysiology of depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been extensively reported to undergo a series of adaptive changes at multiple levels during the depression state. As a crucial relay in brain networks associated with emotion regulation, LHb receives excitatory or inhibitory projections from upstream brain regions related to stress and cognition and interacts with brain regions involved in emotion regulation. A series of pathological alterations induced by aberrant inputs cause abnormal function of the LHb, resulting in dysregulation of mood and motivation, which present with depressive-like phenotypes in rodents. Herein, we systematically combed advances from rodents, summarized changes in the LHb and related neural circuits in depression, and attempted to analyze the intrinsic logical relationship among these pathological alterations. We expect that this summary will greatly enhance our understanding of the pathological processes of depression. This is advantageous for fostering the understanding and screening of potential antidepressant targets against LHb.
Physician assisted-dying in mentally and somatically ill individuals in Switzerland: Protocol for survey-based study
Authors: Kowalinski Eva , Ziltener Tiziana , Staub Sarah , Moeller Julian , Trachsel Manuel , Schneeberger Andres R. , Franke Irina , Lang Undine E. , Huber Christian G.
Published: October 2022

Background

Article 115 of the Swiss Penal Code (StGB) permits physician-assisted dying (PAD), provided it is not performed for “selfish reasons,” and thus, occupies a special role in international comparison. However, the Swiss federal law does not regulate who exactly is entitled to access PAD, and there is no universal agreement in the concerned professional societies. Additional uncertainty arises when assessing the wish for PAD of a mentally ill person compared to a somatically ill person.

Objectives

This study aims to contribute to the discussion of PAD among the mentally ill and to provide insight into the current situation in Switzerland.

Methods

This is a monocentric prospective observational survey-based study. We will conduct an exploratory online/telephone survey about PAD in somatic vs. mental illness in Switzerland. The survey sample will comprise 10,000 Swiss residents of the general population from all three language regions (German, Italian, and French) as well as 10,000 medical professionals working in the seven states (“cantons”) of Basel-Stadt, Basel-Landschaft, Aargau, Lucerne, Graubünden, Ticino, and Vaud. Opinions on PAD in mentally and somatically ill patients will be assessed using 48 different case vignettes. Each participant will be randomly assigned a somatic terminal, a somatic non-terminal, and a mental non-terminal case vignette. Furthermore, the attitude toward the ethical guidelines of the Swiss Medical Association of 2004, 2018, and 2022, as well as the stigmatization of mentally ill people will be assessed.

Discussion

Physician-assisted dying in mentally ill persons is a highly relevant yet controversial topic. On the one hand, mentally ill persons must not be discriminated against in their desire for PAD compared to somatically ill persons while at the same time, their vulnerability must be considered. On the other hand, treating physicians must be protected in their ethical integrity and need security when judging PAD requests. Despite its relevance, data on PAD in the mentally ill is sparse. To regulate PAD for the mentally ill, it is therefore important for Switzerland—but also internationally—to gain more insight into the ongoing debate.

Clinical trial registration

ClinicalTrials.gov, identifier: NCT 05492461.
Prevalence and characteristics of registered falls in a Belgian University Psychiatric Hospital
Authors: de Smet Lynn , Carpels Arnout , Creten Lotte , De Pauw Louise , Van Eldere Laura , Desplenter Franciska , De Hert Marc
Published: October 2022

Objectives

Falls in elderly patients treated in general hospitals have already been the focus of several studies. Research within psychiatric settings, however, remains limited, despite the fact that this population has a number of characteristics that could increase the fall risk. The aim of this retrospective study was to estimate the prevalence of falling in patients with a psychiatric hospital setting.

Methods

A retrospective descriptive chart review of falls registered in the period July 1, 2013 until June 30, 2019 in a Belgian University Psychiatric Hospital was conducted. Data were collected from the “patient related incident report and management system” (PiMS) of the hospital. All registered falls of all hospitalized patients were included in the study.

Results

During the 6-year study period an incidence of 4.4 falls per 1,000 patient days was found. Only 0.5% of the falls resulted in severe injury and none of these falls were fatal. Eighty percent of falls involved a patient over the age of 65. Only 25.0% of the elderly patients suffered physical consequences, while injuries were present in 31.4% of adults and 68.2% of young patients. The two most common causes of a fall were the health status (63.3%) and the behavior (55.1%) of the patient.

Conclusion

The estimated prevalence of falls in our study was generally in line with the rates found in literature on falls in psychiatric settings. Falls in psychiatric settings occur both in younger and older patients, suggesting that all age categories deserve sufficient attention in fall prevention policies. However, more research is necessary to improve fall prevention policies.
Non-exercise activity thermogenesis in the workplace: The office is on fire
Authors: Rizzato Alex , Marcolin Giuseppe , Paoli Antonio
Published: October 2022

From the second half of the previous century, there has been a shift toward occupations largely composed of desk-based behaviors. This, inevitably, has led to a workload reduction and a consequent lower energy expenditure. On this point, small increments of the non-exercise activity thermogenesis (NEAT) could be the rationale to reach health benefits over a prolonged period. Different published researches suggest solutions to reverse sitting time and new alternative workstations have been thought to increase total physical activity. Therefore, the purpose of this narrative review is to summarize the current state of the research regarding the “NEAT approach” to weight-gain prevention in work environments. This review analyzes the main evidence regarding new alternative workstations such as standing, walking workstations, seated pedal, and gymnastic balls to replace a standard office chair.
The prescribing pattern of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in patient with type two diabetes mellitus: A two-center retrospective cross-sectional study
Authors: Korayem Ghazwa B. , Alshaya Omar A. , Alghamdi Albandari A. , Alanazi Shahad S. , Almutib Renad T. , Alsaileek Mahdi , Alrashidi Abdulrahman , Aldosari Nasser , Bin Sheraim Nader , Al Yami Majed S. , Almohammed Omar A.
Published: October 2022

Background

The use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) in patients with type 2 diabetes mellitus (T2DM) remains limited, especially in those with other compelling indications. Thus, this study aimed to describe the prescribing patterns of GLP-1-RA and SGLT2i in patients with T2DM and to determine the factors that affect the prescribing of these medications.

Methods

This multicenter retrospective cross-sectional study reviewed the electronic health records of adult patients diagnosed with T2DM who received care between January and December 2020. The patients were classified according to their compelling indications into “patients who are more likely” to benefit from SGLT2i or GLP-1 RA and “patients who are less likely” to benefit from them. They were then further categorized depending on whether these medications were prescribed.

Results

A total of 1,220 patients were included; most were female (56.9%). SGLT2i or GLP-1 RA were preferably prescribed in only 19% of the patients for reasons including BMI ≥ 27 kg/m2 (85.6%), uncontrolled T2DM (68.5%), high risk for ASCVD (23.9%), or established ASCVD (14%). The remaining 81.0% were underprescribed these agents. Patients at an older age or with a history of stroke or transient ischemic attack had higher odds of being underprescribed (OR 1.02; 95% CI: 1.01–1.03 and OR 2.86; 95% CI: 1.33–6.15), respectively.

Conclusion

The results concur with those of previous studies highlighting the underutilization of GLP-1 RA and SGLT2i in patients with T2DM but also with compelling indications. To optimize the use of GLP-1 RA and SGLT2i for their additional benefits, prescribers need to assess the benefits of using these agents in patients who would likely benefit from them, regardless of DM control.
The effects of forest therapy on public mental health and circular economy: A policy support model in Japan
Authors: Zhang Shujian , Teng Junfei , Zeng Yan , Song Honglin , Gu Zhijun
Published: October 2022

Background

Forest therapy has gained popularity in Japan and even other nations/regions due to its health benefits. In addition, forest therapy has contributed to the development of circular economy and industrial upgrading. Japanese successful practice can serve as a model for other countries in the Asia-Pacific region. To this end, the aim of this study was to determine whether forest therapy can improve the whole well-being of the participants and has a positive effect on the development of circular economy in the region.

Methods

Both empirical and inductive research methods were used; empirical approach was conducted to perform comparative analysis of regional data that was retrieved from the research project of Japanese Forestry Agency in 2015. Specifically, the efficacy of forest therapy on physical (blood glucose, blood pressure, body weight) and mental (sleep quality e.g.,) health outcomes among 815 participants was investigated. Regional data are from the statistics of Iiyama City from 1990 to 2005. After the concept of forest therapy became popular in the late 1990s, this element had a great positive impact on the economic benefits of Ishiyama City and other major forest scenic areas. We summarize and analyze a series of policies made by relevant departments of the Japanese government in the years from 2019 to 2021 to promote forest therapy and related circular industry development.

Results

Significant (pre-to-post participation) changes in physical measure was observed. Firstly, mean weight of those overweight participants decreased across three different time points (pre-test/enrollment = 79.7 kg, 3-month participation = 77.2, and 6-month participation = 76.8 kg), while overall mean weight of the participants decreased to 61, 60.5, and 60.4 kg, respectively. Secondly, Participant with normal weight showed a decrease on mean HbA1C (from 6.09 to 6.06) at Week 24, while overweight participants demonstrated a slight change 6.03–6.01 after 6 months the average HOMA-IR for overweight participants decreased from 3.5 to 2.5 at Week 24, while participants with normal weight demonstrated a decrease from 2.2 to 1.7 at Week 24. Forest Therapy has emerged in Japan since Mid-1990s and has attracted a large number of tourists all over the world due to its unique health benefits.

Conclusion

Forest therapy in Japan has positive effects on whole well-being of Japanese residents and it has helped public mental health promotion and economic growth. Under the guidance and support of government policies, it can promote the development of circular economy and industrial transformation and set a model of Japanese forest therapy development for other countries in the Asia-Pacific region.
Nursing personnel management during COVID-19 pandemic: An exemption trend in view of health reasons
Authors: Sharma Sruti , Dhaliwal Navneet , Bhadada Sanjay , Kumar Ashok , Sangat Sumit Kumar , Pandey Navin
Published: October 2022

Background

In the COVID-19 pandemic, the healthcare system faced unprecedented challenges with increased number of patients and limited resources. Managing nursing resource was a major challenge for hospital administration. They had to be on the frontline, but their safety was of paramount importance.

Aim

This study aims to analyze the measures taken for the management and effective engagement of nursing personnel for deployment in the COVID area of the hospital and the exemption trend based on their health status.

Methodology

A retrospective cross-sectional descriptive study was carried out to analyze the requests of nursing staff received for exemption of duty in COVID patient care areas. These requests were categorized and examined by the medical board constituted for this purpose. Microsoft Excel was used to interpret the results.

Results

The study evaluated the health reasons of nursing officers on the basis of which exemption was given for deployment of nursing officers in COVID areas. They were mostly medical reasons (91.1%) and few personal reasons (8.77%). The majority suffered from diseases affecting two or more than two specialties. Out of 376 applications, 223 were exempted, 81 were not exempted, 13 were given short-term exemption, and 26 were shifted to administrative assignments. Thirty-three staff members were referred to an appropriate forum.
Quality of life and its predictive factors among women with obstetric fistula in Ethiopia: A cross-sectional study
Authors: Hurissa Bekana Fekecha , Koricha Zewdie Birhanu , Dadi Lelisa Sena
Published: October 2022

Objective

Living with obstetric fistulas is detrimental to the quality of life of women with fistulas. This study aimed to assess the quality of life and predictive factors among women with obstetric fistula in Ethiopia.

Methods

A cross-sectional study was employed on consecutively selected 478 women. Linear regressions were used for data analysis.

Results

The mean quality of life in physical, psychological, social, and environmental health domains and the overall quality of life were 40.59 ± 1.58, 38.10 ± 1.78, 29.59 ± 1.97, 34.21 ± 1.65, and 44.61 ± 3.99 respectively. Repair outcome without urinary inconsistence (β = 5.2; 95% CI = 0.72, 9.64), self-esteem (β = 1.3; 95% CI = 0.96, 1.57), negative attitude (β = 5.1; 95% CI = 1.86, 8.33), waiting treatment (β = −8.4; 95% CI = −15.54, −1.10), and low intention (β = 4.7; 95% CI = 1.52, 7.93) were predictors of the quality of life in physical domain. Repair outcome without urinary inconsistence (β = 5.9; 95% CI = 1.73, 9.99), self-esteem (β = 1.8; 95% CI = 1.47, 2.11), negative attitude (β = −6.4; 95% CI = −9.60, −3.25), fathers at primary school (β = 12.5; 95% CI = 0.08, 24.82), living only with parents (β = 4.9; 95% CI = 0.99, 8.90), time of care-seeking (β = −0.01, 95% CI = −0.02, −0.002), and duration lived with fistula (β = −5.4; 95% CI = −9.12, −1.68) were predictors of psychological domain. Dead birth (β = −5.2; 95% CI = −9.86, −0.51), self-esteem (β = 1.1; 95% CI = 0.72, 1.43), and living only with parents (β = 5.5; 95% CI = 0.30, 10.69), and living only with husband (β = 7.8; 95% CI = 2.01, 13.55) were predictors of social domain. Living in rural (β = −6; 95% CI = −9.22, −2.79), women at secondary school (β = 14.1; 95% CI = 3.67, 24.48), self-esteem (β = 1.3; 95% CI = 0.99, 1.55), negative attitude (β = −5.1; 95% CI = −7.97, −2.29) were predictors of quality of life in environmental domain. Repair outcome without urinary inconsistence (β = 8.3; 95% CI = 0.62, 16.02), self-esteem (β = 2.1; 95% CI = 1.34, 2.79), and living only with parents (β = 2.9; 95% CI = 1.06, 4.76) were significant predictors of the overall quality of life.

Conclusions

The quality of life of women with obstetric fistula was low. Repair outcomes, self-esteem, negative attitudes, rural residence, living with parents, and time of care-seeking were significant predictors of quality of life. Urgent measures should be taken to address these factors to improve the quality of life of women with fistula.
High maternal pre-pregnancy BMI is associated with increased offspring peer-relationship problems at 5 years
Authors: Dow Courtney , Lorthe Elsa , Galera Cédric , Tafflet Muriel , Marchand-Martin Laetitia , Ancel Pierre-Yves , Charles Marie-Aline , Heude Barbara
Published: October 2022

Background

Peer relationships are an important aspect of child development that are often overlooked. Maternal pre-pregnancy body mass index (BMI) may influence peer relationships through intrauterine mechanisms affecting fetal neurodevelopment or through postnatal mechanisms including social discrimination of the obese mother/child. This study aimed to determine the relationship between maternal pre-pregnancy BMI and child peer-relationship problems around 5 years old, including preterm and term-born children.

Methods and findings

Maternal BMI and offspring peer-relationship problems were assessed in participants of three French birth cohorts: EDEN (n = 1,184 children born at term), ELFE (n = 10,889 children born ≥33 weeks of gestation) and EPIPAGE-2 (n = 2,646 children born 23–34 weeks of gestation). Reported or measured pre-pregnancy weight (kg) and height (m) were collected from mothers and used to calculate BMI (kg/m2). Offspring peer-relationship problems were assessed using the Strengths and Difficulties Questionnaire at 5.5 years. Logistic regression was used to estimate odds ratios (OR) of a high peer-relationship problem score (≥3) in EDEN and ELFE, and generalized estimated equations were used in EPIPAGE-2 to account for the large number of multiple births. Paternal BMI was used as a negative control in sensitivity analyses. Maternal pre-pregnancy obesity was associated with increased odds of a high peer-relationship problem score in all three cohorts, independent of confounding factors [adjusted OR 2.27 (1.32, 3.88); 1.52 (1.29, 1.78); 1.44 (1.04, 1.99); for EDEN, ELFE and EPIPAGE-2, respectively]. Additional analysis based on negative controls (i.e., adjusting for paternal BMI) showed the same pattern of associations.

Conclusion

High maternal pre-pregnancy BMI is associated with greater likelihood of a high peer-relationship trouble score in offspring around 5 years of age in both children born preterm and at term.