bluuebunny/crossref_metadata_2025 huggingface dataset:
Private quantum channels, conditional expectations, and trace vectors
Authors: Church Amber , Kribs David W. , Pereira Rajesh , Plosker Sarah
Published: March 2021

Private quantum channels are the quantum analogue of the classical one-time pad. Conditional expectations and trace vectors are notions that have been part of operator algebra theory for several decades. We show that the theory of conditional expectations and trace vectors is intimately related to that of private quantum channels. Specifically we give a new geometric characterization of single qubit private quantum channels that relies on trace vectors. We further show that trace vectors completely describe the private states for quantum channels that are themselves conditional expectations. We also discuss several examples.
Nearly deterministic controlled-NOT gate with weak cross-Kerr nonlinearities
Authors: Xiu Xiao-Ming , Dong Li , Gao Ya-Jun , Yi X. X.
Published: March 2021

On the basis of the probe coherent state and weak cross-Kerr nonlinearities, we present a scheme of a nearly deterministic Controlled-NOT gate. In this construction, feed-forward methods, quantum nondemolition detectors and several optical elements are applied. It is a potentially practical quantum gate with certain features. First, the lack of auxiliary photons is allowable, which decreases consumption of resources. Secondly, employment of the signal photon from either of target output ports and three quantum nondemolition detectors enable the success probability to approach unit and judge whether the signal photons lose or not. Thirdly, the displacement measurement is adopted, and thus the Controlled-NOT gate works against photon loss of the probe coherent state. Finally, in order to circumvent the effect of dephasing, the monochromatic signal photons are exploited.
Mixed maximally entangled states
Authors: Li Z. G. , Zhao M. G. , Fei S. M. , Fan H. , Liu W. M.
Published: March 2021

We find that the mixed maximally entangled states exist and prove that the form of the mixed maximally entangled states is unique in terms of the entanglement of formation. Moreover, even if the entanglement is quantified by other entanglement measures, this conclusion is still proven right. This result is a supplementary to the generally accepted fact that all maximally entangled states are pure. These states possess important properties of the pure maximally entangled states, for example, these states can be used as a resource for faithful teleportation and they can be distinguished perfectly by local operations and classical communication.
Some bounds on the minimum number of queries required for quantum channel perfect discrimination
Authors: Lu Cheng , Chen Jianxin , Duan Runyao
Published: March 2021

We prove a lower bound on the $q$-maximal fidelities between two quantum channels $\E_0$ and $\E_1$ and an upper bound on the $q$-maximal fidelities between a quantum channel $\E$ and an identity $\I$. Then we apply these two bounds to provide a simple sufficient and necessary condition for sequential perfect distinguishability between $\E$ and $\I$ and provide both a lower bound and an upper bound on the minimum number of queries required to sequentially perfectly discriminating $\E$ and $\I$. Interestingly, in the $2$-dimensional case, both bounds coincide. Based on the optimal perfect discrimination protocol presented in \cite{DFY09}, we can further generalize the lower bound and upper bound to the minimum number of queries to perfectly discriminating $\E$ and $I$ over all possible discrimination schemes. Finally the two lower bounds are shown remain working for perfectly discriminating general two quantum channels $\E_0$ and $\E_1$ in sequential scheme and over all possible discrimination schemes respectively.
Realization of an economical phase-covariant telecloning in separate cavities
Authors: Fang Bao-Long , Wu Tao , Ye Liu
Published: March 2021

We present a scheme to realize an economical $1 \to 2$ phase-covariant telecloning in separate cavities. In the scheme, an entangled state between a photon pulse and the tapped atoms will be prepared through cavity-assisted interaction. Next, the Bell state measurement is execute on the photon pulse and a trapped atom or another photon pulse on which the quantum information is encoded. In this way, the system can provide symmetric (asymmetric) economical $1 \to 2$ phase-covariant telecloning.
Constant-optimized quantum circuits for modular multiplication and exponentiation
Authors: Markov Igor L. , Saeedi Mehdi
Published: March 2021

Reversible circuits for modular multiplication $Cx\%M$ with $x<M$ arise as components of modular exponentiation in Shor's quantum number-factoring algorithm. However, existing generic constructions focus on asymptotic gate count and circuit depth rather than actual values, producing fairly large circuits not optimized for specific $C$ and $M$ values. In this work, we develop such optimizations in a bottom-up fashion, starting with most convenient $C$ values. When zero-initialized ancilla registers are available, we reduce the search for compact circuits to a shortest-path problem. Some of our modular-multiplication circuits are asymptotically smaller than previous constructions, but worst-case bounds and average sizes remain $\Theta(n^2)$. In the context of modular exponentiation, we offer several constant-factor improvements, as well as an improvement by a constant additive term that is significant for few-qubit circuits arising in ongoing laboratory experiments with Shor's algorithm.
The monomial representations of the Clifford group
Authors: Appleby D. Markus , Bengtsson Ingemar , Brierley Stephen , Grassl Markus , Gross David , Larsson Jan-Ake
Published: March 2021

We show that the Clifford group---the normaliser of the Weyl-Heisenberg group---can be represented by monomial phase-permutation matrices if and only if the dimension is a square number. This simplifies expressions for SIC vectors, and has other applications to SICs and to Mutually Unbiased Bases. Exact solutions for SICs in dimension 16 are presented for the first time.
A Dynamic Substrate is Required for MhuD-catalyzed Degradation of Heme to Mycobilin
Authors: Thakuri Biswash , O'Rourke Bruce , Graves Amanda , Liptak Matthew
Published: March 2021

The non-canoncial heme oxygenase MhuD from Mycobacterium tuberculosis binds a heme substrate that adopts a dynamic equilibrium between planar and out-of-plane ruffled conformations. MhuD degrades this substrate to an unusual mycobilin product via successive monooxygenation and dioxygenation reactions. This article establishes a causal relationship between heme substrate dynamics and MhuD-catalyzed heme degradation resulting in a refined enzymatic mechanism. UV/Vis absorption (Abs) and electrospray ionization mass spectrometry (ESI-MS) data demonstrated that a second-sphere substitution favoring population of the ruffled heme conformation changed the rate-limiting step of the reaction resulting in a measurable build-up of the monooxygenated meso-hydroxyheme intermediate. In addition, UV/Vis Abs and ESI-MS data for a second-sphere variant that favored the planar substrate conformation showed that this change altered the enzymatic mechanism resulting in an alpha-biliverdin product. Single-turnover kinetic analyses for three MhuD variants revealed that the rate of heme monooxygenation depends upon the population of the ruffled substrate conformation. These kinetic analyses also revealed that the rate of meso-hydroxyheme dioxygenation by MhuD depends upon the population of the planar substrate conformation. Thus, the ruffled haem conformation supports rapid heme monooxygenation by MhuD, but further oxygenation to the mycobilin product is inhibited. In contrast, the planar substrate conformation exhibits altered heme monooxygenation regiospecificity followed by rapid oxygenation of meso-hydroxyheme. Altogether, these data yielded a refined enzymatic mechanism for MhuD where access to both substrate conformations is needed for rapid incorporation of three oxygen atoms into heme yielding mycobilin.
Unraveling the Allosteric Cross-Talk Between Coactivator Peptide and Ligand Binding Site in Glucocorticoid Receptor
Authors: La Sala Giuseppina , Gunnarsson Anders , edman karl , Tyrchan Christian , hogner anders , Frolov Andrey
Published: March 2021

Glucocorticoid receptor (GR) is a nuclear receptor that controls critical biological processes by regulating thetranscription of specific genes. There is a known allosteric cross-talk between the ligand and coregulator bindingsites within the GR ligand binding domain that is crucial for the control of the functional response. However, themolecular mechanisms underlying such an allosteric control remain elusive. Here, molecular dynamics (MD)simulations, bioinformatic analysis and biophysical measurements are integrated to capture the structural anddynamic features of the allosteric cross-talk within GR. We identified a network of evolutionarily conservedresidues that enables the allosteric signal transduction, in agreement with experimental data. MD simulationsclarify how such network is dynamically interconnected and offer a mechanistic explanation of how the differentpeptides affect the intensity of the allosteric signal. This study provides useful insights to elucidate the GRallosteric regulation, ultimately, posing the foundation for designing novel drugs.
Corona Virus: A Pandemic
Authors: Akash Ande
Published: March 2021

In the midst of the continuous CORONA VIRUS pandemic, India has seen a gigantic flood of new cases in the previous 21 days. As of April month, 34,000 affirmed cases and 1074 passings have been accounted from near all the states/association regions of India. India has expanded the testing rate, has particularly fortified the medical services area to the battle of Coronavirus along with cross country lockdown. India with populance of more than 1.3 billion individuals which is a critical populace thickness in fact and the absence of all inclusive admittance to unsoiled water and generally speaking impoverished financial status, all have encouraged significant test to India's battle against Coronavirus. Not being able to control India's pandemic situation could have shocking results along with boundless cases and a large number of passings that could undoubtedly overpower the medical services framework of whole India. Could be converted into hotspot soon due to such devastating spread of pandemic of coronavirus.The WHO has expressed that "eventual pandemic's fate will rely upon how India handles it. During this time, our nation India is facing various tough challenges to fight against the pandemic coronavirus, so in this article, I have tried to collect the information about the current situation of India.
A concise review of oil pulling as a precautionary measure in COVID-19 pandemic
Authors: Twinkal Mahakale  , Gaurav Sawarkar  , Vaishali Kuchewar  , Pramod Khobragade
Published: March 2021

COVID-19 pandemic situations generate myths that create doubt in society that things have to follow due to some misunderstanding and inadequate shreds of evidence ancient medicine lacking behind despite tremendous potential. Various modalities are in force to prevent a pandemic situation; the Dept of AYUSH is playing a very vital role in this condition. The dept. of AYUSH, Govt. of India giving rise to funding to various research institutes, private organizations, and deemed universities. Simultaneously, to combat pandemic situation AYUSH department focusing on Yoga, Pranayama, consumption of immunomodulatory drugs, herbal medicines, diet regimen and release protocol for COVID-19 mild, moderate and severe conditions. In Ayurveda the Kriyakalpa have mentioned: the therapeutic procedures used to cure the disease and practicably act with prescribed guidelines for specific disorders related to the eyes and ear. The Gandush (oil pulling), one of the types of Kriyakalpa, also can be useful to prevent airborne infections. This procedure helps for the oral cavity's excellent health, which can avoid diseases through the air, increasing the immunity power of surrounding organs and avoiding favorable conditions to get infected. It is readily responsive to clear nasal and oral route and decrease Kapha Dosha. This is a very cost effective and easily adoptable procedure having a negligible diet regime and precautionary measures.
Psychosocial Effects and Panic Regarding Corona Virus
Authors: Amir Ali
Published: March 2021

After the hike of the Coronavirus from the country of China in the end of the previous year, Novel Coronavirus accounts for a total of about 46 million cases all around the world with the death of more than 1.28 million individuals & 31.8 million recoveries. Besides its extraordinary infectivity & casualty rates, Corona Virus Disease has caused widespread panic, economic weight & budgetary misfortunes. Mass terror of CORONA VIRUS, named as "corona phobia", has made an adequate mental indications in over-all population. Along these lines, this audit has been embraced to characterize panic consequence of CORONA Virus. The quarantine can create extreme anger, nervousness, accumulating, psychological illness & sadness. Strengthened through an "infodemic" extent through a various foundation in web-based broadcasting. Upheavals bigotry, defamation, & tolerance against specific networks remain additionally being broadly detailed. All things considered, bleeding-edge medical services laborers are at higher danger of getting the illness just as encountering unfriendly mental results in a type of burnout, tension, fear of communicating contamination, a sentiment of contrariness, wretchedness, & extended substance-reliance. Network-based alleviation projects to battle coronavirus will upset youngster normal way of life & may cause flowery psychological depression. Networks remain pretentious by disease in several manners & want exceptional consideration.
A case report on Staphylococcal Scalded Skin Syndrome in a 3 year old: Clinical diagnosis and management
Authors: Gayathri Sunil  , Meghana Vinod  , Neethu C M  , Jis Ann Maria  , Vinitha Prasad
Published: March 2021

Staphylococcal-scalded skin syndrome (SSSS) is a blistering skin disorder which is considered as a pediatric emergency. This life-threatening syndrome is caused by Staphylococcal exfoliative toxins produced by Staphylococcus aureus. Although it can affect any age group, children below 5 years of age are at utmost risk. The specific antibodies to exotoxins and increased exotoxin clearance, minimize the frequency of SSSS in adults. Mortality in infancy is low (4%) and is less than 10 % in children but is between 40% and 63% in adults.  Clinical features of SSSS may range from a few localized blisters to generalized desquamation covering the entire body. The histopathological evaluation of the skin biopsy helps in the definitive diagnosis of SSSS.  Here we present a case of a 3 year old female child with low grade fever associated with erythematous rashes all over the body and severe itching. A clinical diagnosis of Staphylococcal Scalded Skin Syndrome (SSSS) was made. With appropriate treatment using intravenous Flucloxacillin and supportive care, the child’s symptoms were completely resolved within a week.
The Mediation Role of Organizational Slack And Innovation Climate on The Effect of Perceived Organizational Support in Academic Performance
Authors: Taha Meero Dilshad
Published: March 2021

The main objective of this research is to examine the mediation role of both organizational slack and innovation climate on the effect of perceived organizational support on academic performance at the colleges of Duhok University by using path analysis. The research reviews the contributions of researchers on the subjects of perceived organizational support (POS), organizational slack (OS), innovation climate (IC), and academic performance (AP). Constructing on previous studies, a set of hypotheses are formulated to express the effect of the POS, OS, IC variables on AP variable. A sample of 181 lecturers were selected to verify research hypotheses which have been proposed. Finally, the main conclusions of the research are presented. The results of the investigation reveal that the organizational slack and innovation climate variables mediates the influence between the perceived organizational support and the academic performance and that the indirect effect between the perceived organizational support and the academic performance was stronger than the direct influence between them.
Network Connection and Energy Radiation through Grassroots Master Teacher Studios
Authors: Feng Panjing
Published: March 2021

Distributed leadership is a collective leadership mode in which multiple members of the organization dynamically share leadership roles according to changes in capability and environment, so as to achieve leadership sharing and leadership energy radiation. Facing the distributed leadership practice of Master Teacher Studio that really occur in education management can make our understanding and description of its original ecological and endogenous construction process more objectively, meticulously and deeply. Through the generation and expansion of the case studio with the characteristics of "grassroots", the empowerment and differentiation of leaders, the stimulation and radiation of members leadership, the generation process of "grassroots" Master Teacher Studio from the initial construction of "uniline" mode to "network" distribution connection, and the radiation process of Master Teacher Studio members' energy from "uninuclear transmission" to "multinuclear connection". Thus, it will realize the organic integration of Western distributed leadership theory and localized grassroots master teachers' studio practice.
EVALUATION OF SOME QUALITY INDICATORS AND PROSPECTS FOR USING DIFFERENT VARIETIES OF PEAR FRUIT IN MEDICINE
Authors: A.N. Dosayeva , N.V. Nesterova
Published: March 2021

In this article, the authors studied the macrodiagnostic characteristics of pear fruits of three varieties that are most common in the food markets of the Russian Federation. To date, the standardization of such promising and rich in the composition of biologically active substances (BAS) raw materials is carried out only in accordance with the state Standards of the food industry. The research was aimed at developing quality indicators necessary for identifying raw materials that could be considered as a source for obtaining medicinal substances. For all the studied fruits, the total content of extractive substances, organic acids in terms of malic acid and pectin substances was determined. The content of extractive substances was from 15.8% to 17.6%, organic acids - from 0.34% to 1.09%, pectin substances - from 1.15% to 1.87%. As a result of the qualitative reactions, the data of TLC-spectrophotometric method pear fruits, the varieties which are most widely cultivated on the territory of the Russian Federation, was identified as arbutin, which allows to consider the material as a promising source of valuable biologically-active substances and actualizes the further research aimed at developing modern methods of standardization for inclusion in the proposed regulatory documentation.
FACTORS PROVOKING EPILEPTIC SEIZURES
Authors: N.G. Tokareva , O.I. Ignatieva
Published: March 2021

Currently, the most significant problems of adherence to modern pharmacotherapy have been identified. The urgency of the treatment of epilepsy is confirmed by its frequency of spread. In Russian neurology, epilepsy is treated in accordance with international standards and recommendations. For a number of years, the drugs of the first stage of choice have proven their effectiveness. Monotherapy is preferred; with the development of drug-resistant epilepsy, the possibilities of using a combination of antiepileptic drugs are considered. Epileptic activity in the form of increased seizure frequency can be triggered by alcohol consumption, sleep disturbance - wakefulness, stressful situations, eye strain, somatic diseases and other factors. The aim of this study was to determine the main factors of provocation leading to an increase in the frequency of seizures in epilepsy. Materials and methods: we carried out a retrospective analysis of 43 case histories of patients with increased seizure rates who were hospitalized in the neurological department of one of the central clinical hospitals in Saransk. The initiation of anticonvulsant drug therapy in all patients coincided with the justification of the diagnosis. Seizure remission was achieved in the first year of treatment in most patients, which indicates a good level of compliance and coincides with clinical guidelines. Most patients in the sample received monotherapy with antiepileptic drugs of the first choice. An increase in seizures in patients taking antiepileptic drugs was noted at 3 years of treatment. Results: the most frequent factor provoking seizures was non-adherence to the therapy regimen, which was often mistakenly interpreted by outpatient doctors as the development of drug-resistant epilepsy; patients were referred to inpatient treatment for alternative monotherapy or combination therapy. Non-compliance with the therapy regimen was noted in the form of a decrease in the dose of the drug, irregularity of administration, and forgetfulness of the patient. Other factors provoking an increase in the frequency of epileptic seizures accounted for a significantly lower percentage and did not have a relevant significance
CHOOSING THE OPTIMAL TECHNOLOGY FOR OBTAINING DRY STRAWBERRY LEAF EXTRACT
Authors: O.V. Yaborova , S.A. Sosnina , A.Yu. Turyshev
Published: March 2021

In recent years, there has been an increasing interest in medicines produced on the basis of medicinal plant raw materials. To improve the quality of drug supply to the population and expand the range of medicines, research is relevant to improve the efficiency of the extraction methods used, replacing infusions and decoctions with industrial products. In this regard, the study of the technological parameters of obtaining an extract from the leaves of dry strawberry is of practical interest for the further development of dosage forms with it and the formation of a scientific justification for their use in medical practice.
PECULIARITIES OF MOTIVATION-NEEDED SPHERE OF PATIENTS WITH EPILEPSY: CLINICAL AND PSYCHOLOGICAL ASPECT
Authors: N.G. Tokareva , O.I. Ignatieva
Published: March 2021

Epilepsy is a common neuropsychiatric disease in which a number of personality characteristics change. Motivation takes one of the main places in the structure of the patient's personality. Motivation largely determines human behavior, is an important component, since it helps to understand the features and directions of human activity. A motive is an impulse to activity, which is associated with the goal of satisfying the arisen desires. Only by understanding how the patient's motivational-need sphere is arranged, it is possible to determine the patient's role, the degree of his participation in treatment-and-prophylactic measures, as well as influence the formation of motivation, motivate the sick person for educational activities, labor, production activities, etc. The study of the characteristics of the patient's motivational-need sphere is necessary in order to understand how the patient's motivation is formed in the treatment process, how important it is in his life and whether the patient will be able to effectively manage life, enjoy reality, successfully look and plan the future, precisely based on his own motive. That is why the problem of motivation is very relevant at the present time. This work analyzes the features of the motivational-need-related sphere of patients with epilepsy. The study included 317 patients aged 18 to 65 years with focal forms of epilepsy, whose structure was dominated by simple, complex partial seizures. Verification of the diagnosis in the examined patients was carried out on the basis of the results of clinical neurological, psychopathological, pathopsychological, electroencephalographic examination and computed tomography of the brain. The study used a methodology for assessing the level of claims: V. Gerbachevsky's questionnaire. Clinical and psychological research of patients with epilepsy made it possible to substantiate the choice of 2 clusters: the first cluster included able-bodied working patients – n=131 (41.3%), the second cluster - non-working patients – n=186 (58.7%).
In the 1st cluster, indicators on the scales "Level of mobilization of efforts", "Regularity of results", "Cognitive motive" prevail, in the 2nd cluster indicators on the scale "Avoidance" prevail. Taking into account the motivational-need-oriented orientation of the patient is an important component in the construction of therapeutic programs aimed at improving the quality of medical care.
RESEARCH ON THE CREATION OF AN APPLICATION SYSTEM FOR THE TREATMENT OF WOUND PROCESSES
Authors: D.A. Petrukhina , I.V. Pletneva , Y.S. Pokrovskaya
Published: March 2021

One of the promising areas of the pharmaceutical industry is the development of local drug delivery systems consisting of a biocompatible matrix and a drug. Such local delivery systems include medicinal films. Ensuring pharmacological action, accuracy of dosing, strong fixation to damaged tissues of the mucous membrane, prolongation of action are the undoubted advantages of medicinal films in comparison with traditional means of treating wound processes. The development of the technology of the drug film containing in its composition the drug cycvalone, which has a wide range of biological activity-antioxidant, anti-inflammatory, antibacterial and others - is an urgent task of pharmacy.
As a result of the conducted research, the technology of a drug film with cycvalone in the form of an inclusion complex with β-cyclodextrin based on a matrix of a biodegradable polymer of sodium alginate was developed. It should be noted the availability, safety and pharmacological effectiveness of medicinal substances used in the technology of the dosage form. The inclusion of cyclodextrin in the composition of the film is due to the solubilization of the active substance molecule and an increase in the bioavailability of cycvalone during application therapy. Introduction of cycvalone in the form of complex inclusion also has a positive effect on the uniformity of distribution of the drug in the matrix and, consequently, determines the accuracy of drug dosing. After the release of the active substance, cyclodextrin is able to show detoxifying properties in the wound. The use of a modern biodegradable material as a film-forming agent provides a prolonged action of active substances, high bioavailability and enhanced therapeutic properties of the composition.
The values of quality indicators of medicinal films confirming the rational selection of the composition and the optimal technology of the dosage form were experimentally established.
THE ROLE OF AGONISTS AND ANTAGONISTS OF THE WNT SIGNALING PATHWAY IN PATIENTS WITH ANDROGENIC ALOPECIA AND ALOPECIA AREATA
Authors: A.V. Samoylova , I.A. Snimshchikova , M.O. Plotnikova , N.Y. Yakushkina
Published: March 2021

Alopecia is a common pathology among the active population, which leads not only to cosmetic defects, but also to the development of somatic diseases against the background of traumatic effects and chronic stress. The pathogenetic mechanisms of hair follicle formation are complex and diverse, since numerous factors, including the components of the Wnt signaling pathway, have an effect on its morphogenesis, the study of which is the subject of this study. The search for possible early markers of the development of alopecia led to interest in the study of the main morphogenic proteins of WNT - the signaling pathway (one of the intracellular signaling pathways, which control the development of blood vessels, as well as the growth and division of hair follicle cells) sclerostin and β-catenin among patients with androgenic and alopecia areata. The article presents data on the quantitative content of β-catenin and sclerostin in the blood serum in patients with androgenic and alopecia areata. Their possible pathways of complex interaction and influence on the morphogenesis of the hair follicle and the activity of the Wnt-signaling pathway have been analyzed, and the relationship between changes in the level of morphogenic proteins of the WNT-signaling pathway with sex and the course of the disease has been described. Establishment of the prognostic role of morphogenic proteins of the WNT signaling pathway in androgenic and alopecia areata will allow not only identify the personal risk of disease progression and to determine approaches to targeted therapy, but to develop and introduce updated diagnostic screening into dermatological practice.
Pharmacoeconomic features of the use of drugs used in the treatment of allergic rhinitis
Authors: T.G. Afanasyeva , N.N. Lavrova , V.R. Tumentseva
Published: March 2021

Rhinitis is an inflammation of the nasal mucosa; today, according to the World Health Organization, the prevalence of the disease is 40% of the world's population. Allergic rhinitis is the most common type of chronic rhinitis, affecting 10–20% of the world's population, and the severity of the disease is associated with a significant deterioration in the quality of life, sleep and performance. Allergic rhinitis is an inflammatory disease of the nasal mucosa caused by exposure to an allergen, causing IgE-mediated inflammation. Clinically, the disease is characterized by the following main symptoms: rhinorrhea, sneezing, itching and nasal congestion. Despite the general symptoms of allergic rhinitis, its impact on the quality of life of patients and the significant cost of treatment, including pharmacotherapy, many patients do not adhere to drug treatment regimens due to their insufficient effectiveness in eliminating the emerging symptoms. Pharmacoeconomic research identifies, measures and compares the costs and effects of drug use. This framework includes research methods related to cost minimization, cost-effectiveness, decision analysis, cost of illness, and patient quality of life. This article will consider one of the four main methods for assessing pharmacoeconomics - cost minimization analysis. A cost-minimization analysis is a pharmacoeconomic assessment by comparing the costs of two or more drug alternatives regardless of outcome. Since the pharmaceutical market is represented by a wide range of original, reference and generic drugs for the treatment of allergic rhinitis, an important aspect of our research is the selection of effective and economically acceptable therapy for outpatients.
EDUCATIONAL MICROENVIRONMENT AS A CONDITION FOR THE GIFTEDNESS DEVELOPMENT IN SENIOR PRESCHOOL AGE
Authors: N.B. Shumakova , E.S. Belova
Published: March 2021

The article is devoted to the problem of conditions for the development of gifted children in kindergarten. The main attention is paid to the peculiarities of the modern educational microenvironment that contributes to the development of gifted older preschoolers. The article presents the results of a study in which 113 children of 6-7 years old with high intellectual abilities took part. Children attended preparatory groups for kindergartens with different microenvironments. A comparative analysis of the developmental features of extraordinary preschoolers was carried out in an enriched educational microenvironment (40 children) and in a typical microenvironment (73 children). The assessment of intellectual development was carried out using the methodology for diagnosing intellectual abilities of MEDIA, intellectual and creative activity - using a diagnostic game lesson. As a result of univariate analysis of variance, it was found that the educational microenvironment, which allows an intellectually gifted preschooler to realize his need for exploring the world and show his creative abilities, makes a significant contribution to the development of his cognitive initiative and intellectual and creative activity (10.6% of the variance of this indicator at p <0.000), thereby contributing to the favorable development of the potential of children's giftedness. It is shown that the features of the content of education (interdisciplinary nature, cognitive complexity and variety of topics), the dominance of research and creative activity, the relationship of cooperation, the encouragement of creative activity and independent search are specific characteristics of the developing educational microenvironment for gifted preschoolers. It is substantiated that the creation of a developing educational microenvironment for gifted preschoolers is impossible without special training of educators aimed at teaching them to accept and appreciate the uniqueness of the child, to help him interact with other children, to discover his hobbies and to explore the world.
THE RELEVANCE OF EXISTENTIAL DANITIES IN PREPARATION FOR THE PROFESSIONAL ACTIVITY OF A HELPING SPECIALIST
Authors: E.P. Korablina , S.B. Pashkin , E.I. Braznik , N.B. Lisovskaia , P.D. Abramova
Published: March 2021

Professions aimed at helping and supporting a person in a difficult situation, with their traditions and principles of assisting activities, have existed since ancient times. The main purpose of the helping professions is to improve the quality of life of the person who sought help and to activate his inner potential. The importance of existential problems and their solution in the way of the professions plays a special role, since only a harmonious person who has reached agreement with himself and the outside world can fully open up in the profession. Despite the individual specifics of each profession; regardless of the direction of his work, the helper must have not only a certain set of personal qualities and a proper level of professional knowledge, but also an understanding, awareness and acceptance of the level of responsibility that he bears for what is happening in the work process. The study describes the relationship of future aid specialists to existential problems, professional responsibility and future profession.
CHANGES IN THE DIET OF STUDENTS DURING LOCKDOWN
Authors: E.S Nagornov , O.V. Nesterova
Published: March 2021

In the Russian Federation, in connection with the impend-ing threat of the spread of the epidemic, in order to pre-vent the spread of a new coronavirus infection, it was decided to introduce a self-isolation regime. Obviously, changes in the lifestyle in a certain way affected the diet of the population. The article analyzes the change in the nutrition of students of higher medical educational insti-tutions in this period. The authors developed and con-ducted a survey of young people and found that the stu-dents' nutrition is quite diverse. However, with a decrease in physical activity, the caloric content of the diet in-creased, which can lead to an increase in body weight, an increase in glucose and cholesterol levels. These factors, combined with stress caused by drastic changes in life-style, are predictors of chronic disease.
DIAGNOSTIC CRITERIA EARLY DIAGNOSIS ENDOMETRIOSIS
Authors: D.R. Bakhtiyarova
Published: March 2021

The purpose of this study is to study a clinical case of late diagnosis of endometriosis of the uterine body (adenomyosis), despite the presence of such typical clinical manifestations as heavy uterine bleeding, leading to the formation of chronic post – hemorrhagic iron deficiency anemia and the development of sideropenic syndrome, accompanied by weakness, dizziness, rapid fatigue, brittle hair and nails. Also, the data of the family history (endometriosis in the mother) and the patient's history indicating the presence of pollinosis and bronchial asthma were not taken into account.
COLOURED FRUITS AND VEGETABLES FOR HEALTHY BODY
Authors: Khatri Amrita
Published: March 2021

Fruits and vegetables are extremely essential to our healthiness because they are whole foods, produced by natural world. They are rich in a large amount of nutrients, as they possess fiber, vitamins, and enzymes .Each different color fruit and vegetable contains unique health components that are essential to our health.Green color is very crucial in diet. Green vegetables contain chlorophyll, calcium, folate, vitamin C, calcium, and beta-carotene. The green fruit and vegetables are also rich in phytochemicals which are important in keeping the healthy body e.g. spinach has carotinoids, lutein and zeaxanthin .The antioxidant properties possessed by broccoli are good to defend the eyes by keeping the retina healthy and powerful. Peas and lima beans are also good sources .The green Fruits and vegetables are also encumbered with necessary minerals and fibers. The green vegetables are loaded with cancer blocking chemicals like sulforaphanes, isosynate and indols which reduces the stroke of carcinogens. They are also associated with reduction of cataract and age related muscular degeneration, thus also controls blindness. The nutrients found in these vegetables reduce cancer risks, lower blood pressure, LDL cholesterol levels, normalize digestion time, support retinal health and vision, fight harmful free-radicals, and boost immune system activity. Green colour of fruits and vegetables enhances calcium absorption, boosts mental alertness and helps in cell regulation.
'POET'S THEATER'
Authors: Gangarade Sandhya
Published: March 2021

The creator, the Creator, the creator, by whatever name, calls the ultimate power that colors the sky blue, the earth green, the sun gold and the moon silver. The colors of Pushpavali in the forest division are countless and the colors of water creatures in the ocean are amazing. Colorless water is also the miracle of the same and the white, black and red color of Ganga, Yamuna and Saraswati is also an expression of the same. Some also create 'Kavirmanishi Paribhu Swayambhu', the poet of the world of life, nature's colors with full sensibility Does. In poetry, there are mainly three basic colors - white, black, white, black and red.

सृष्टा, रचेता, विधाता जिस भी नाम से पुकारें उस परम शक्ति को जो आकाश को नीला, धरती को हरा, सूरज को स्वर्ण और चाँद को रजत रंग में रंग देता है। वन प्रान्तर में पुष्पावलि के रंग अनगिनत है और सागर में जल-जीवों के रंग अद्भुत। रंगहीन जल भी उसी का चमत्कार है और गंगा, यमुना और सरस्वती का श्वेत, श्याम और लाल रंग भी उसी की अभिव्यक्ति है।कवि भी रचेता है ‘कविर्मनीषी परिभू स्वयंभू’ जीवन के जगत के, प्रकृति के रंगो को कवि पूरी संवेदन शीलता से संयोजित करता है। काव्य में मुख्य रूप से तीन रंग आधारभूत रंग है- श्वेत, श्याम, रतनान-सफेद, काला और लाल।
PSYCHOLOGICAL EFFECTS OF COLOR AND COLOR THERAPY
Authors: Chaudhary Abhilasha
Published: March 2021

And the mind has a close relationship, we all know this. A healthy mind selects a healthy body and a healthy body. Color is the medicine of mind and soul and hence it has the ability to resist various physical mental diseases. Colors have an important place in the life of a human being. Varna is an element entirely dependent on light and vision. The absence of even one proves to be a hindrance to the knowledge of color. Every object must have some color and basically the objects are identified due to their surface color and the amount of light is more or less the same color makes the object appear different.

और मन का घनिश्ठ सम्बन्ध है, ये तो हम सभी जानते है। स्वस्थ मन स्वथ्य षरीर शरीर और स्वस्थ्य षरीर ही निर्विकार मन का वरण करता है। रंग, मन और आत्मा की औशधि है और इसीलिये वह विभिन्न षारीरिक मानसिक रोगों का प्रतिरोध करने की क्षमता रखती है। मनुष्य के जीवन में रंगों का महत्वपूर्ण स्थान है। वर्ण पूर्णतः प्रकाष व दृश्टि पर निर्भर तत्व है। एक की भी अनुपस्थिति रंग के ज्ञान में बाधक सिद्ध होती है। प्रत्येक वस्तु का कोई न कोई रंग अवष्य होता है और मूलतः वस्तुओं की पहचान उनके धरातलीय रंग के कारण ही होती है तथा प्रकाष की मात्रा के कम या अधिक होने से एक ही रंग की वस्तु अलग-अलग दिखलायी पडती है।
WITH COLOR EXPRESSIONS IN PROVERBS / IDIOMS
Authors: Srivastava Sushma
Published: March 2021

The proverb is directly related to the expression side of the common people. Experience of the reality of human life is embedded in the background of the proverb. It is related to the eternal truth. The proverb is complete in itself. It freely connotes a specific meaning. The proverb and idiom provide the elixir of language. Using them, the language incorporates liveliness, simplicity, pictorialism and efficacy. The word 'idiom' derives from the Arabic language which means 'practice' or 'conversation' but now this word conveys a special meaning. Idioms are used as sentences in sentences. "A phrase prevalent in written or poetic language, which is proved by the symptom or euphemism due to its singular meaning in general, is called idiom." We can also call it symptomatic language.

लोकोक्ति का सीधा संबंध जनसामान्य के अभिव्यक्ति पक्ष से है। लोकोक्ति की पृष्ठभूमि में मानव-जीवन के यथार्थ का अनुभव सन्निहित होता है। यह चिरंतन सत्य से संबंधित होती है। लोकोक्ति अपने आप में पूर्ण होती है। यह स्वतंत्र रूप से विषेष अर्थ को ध्वनित करती है। लोकोक्ति ओर मुहावरे भाषा के उत्कर्ष का विधान करते हैं। इनके प्रयोग से भाषा में सजीवता, सरसता, चित्रात्मकता व प्रभावोत्पादकता का समावेष होता है।‘मुहावरा‘ षब्द अरबी भाषा से निकला है जिसका मूल अर्थ है ‘अभ्यास‘ या ‘बातचीत‘ किन्तु अब इस षब्द से एक विषेष अर्थ ध्वनित होता है। मुहावरों का प्रयोग वाक्य मे ंवाक्यांष के रूप में होता है। ”लिखित अथवा काव्य भाषा में प्रचलित वह वाक्यांष जिसका अर्थ सामान्य अर्थ से विलक्षण होने के कारण लक्षणा अथवा व्यंजना द्वारा सिद्ध होता है उसे मुहावरा कहते हैं।“ हम इसे लक्षणा प्रधान भाषा भी कह सकते हैं।
COLOR VISION DEFECT: COLOR BLINDNESS
Authors: Shakya Sudha
Published: March 2021

Humans have many types of sensations such as sight, hearing, touch, smell, taste etc. They originate from stimulants, which a person receives from their external environment, stimulate the stimulating senses i.e. eye, ear, skin, nose and tongue, and produce different sensations. According to Eiseneck (1972), "sensation is a mental process that is no longer divisible." It is produced by external stimuli that affect the senses, and its intensity depends on the stimulus, and its properties depend on the nature of the senses. Apart from these five sensations, there are other sensations such as incidental sensation, static sensation and motion sensation.

मानव में कई प्रकार की संवेदनाएं होती हैं जैसे दृष्टि, श्रवण, स्पर्श, गंध, स्वाद आदि। इनकी उत्पत्ति उद्दीपकों से होती है, जिसे व्यक्ति अपने बाह्य पर्यावरण से ग्रहण करता है, यह उद्दीपक ज्ञानेन्द्रियों अर्थात आंख, कान, त्वचा, नाक और जिव्हा को उद्दीप्त करते हैं, और विभिन्न संवेदना को उत्पन्न करते हैं। आइजनेक (1972) के अनुसार ‘‘ संवेदना एक मानसिक प्रक्रम है जो आगे विभाजन योग्य नहीं होता। यह ज्ञानेन्द्रियों को प्रभावित करने वाली बाह्य उत्तेजना द्वारा उत्पादित होता है, तथा इसकी तीव्रता उत्तेजना पर निर्भर करती है, और इसके गुण ज्ञानेन्द्रिय की प्रकृति पर निर्भर करते हैं। इन पांच संवेदनाओं के अतिरिक्त अन्य संवेदना भी है जैसे आंगिक संवेदना, स्थैतिक संवेदना तथा गति संवेदना।
IMPORTANCE OF COLORS IN THE LIFE OF TRIBES OF MADHYA PRADESH
Authors: Kumar Vijay
Published: March 2021

Colors are always encouraging, the natural properties of colors are the rays of light, which by their wavelengths transform the vibrations of the innermost of the creatures and creatures in nature. The taste and taste are inferior, yet the creature experiences color and taste from its experience. Whose influence plays an important role in his life. Life also gives man the art of living according to his karma, karma is directly related to art. If you define art as the life of a human being, then this fact comes, which is moving and mentally stimulate. Man is physically mortal, soul is considered immortal. The form, color of the soul is visually impaired, but man is able to give it a visual appearance through art. Color and form are the means by which a man is able to express himself to other beings. Man gives the form of visual appearance in different ways, but by using color combination in it, it makes it energetic.

रंग सदैव उत्साहवर्धन करते हैं, रंगों का प्राकृतिक गुण ही प्रकाश की किरणें होती हैं, जो अपनी तरंगदैध्र्य से प्रकृति में व्याप्त जीवों और प्राणियों के अन्तर्मन के कंपन को ऊर्जा में परिवर्तित करती है। रंग-स्वाद हीन होते हैं, फिर भी प्राणी अपने अनुभव से रंग-स्वाद की अनुभूति करता है। जिसका प्रभाव उसके जीवन में महत्त्वपूर्ण भूमिका निभाते हैं। जीवन, मनुष्य को अपने कर्म के अनुसार जीने की कला भी प्रदान करता है, कर्म का सीधा सम्पर्क कला से है। कला को मनुष्य के जीवन के रूप में परिभाषित करें तो यह तथ्य आता है, जो गतिमान हो और मानसिक रूप से उद्वेलित करें। मनुष्य शारीरिक रूप से नश्वर होता है, आत्मा को अमर माना जाता रहा है। आत्मा का रूप, रंग दृष्टिहीन होता है, लेकिन मनष्ुय कला के माध्यम से इसे दृष्टिगत रूप देने में सक्षम होता है। रंग और रूप ऐसा माध्यम है, जिसके द्वारा मनुष्य अपनी अभिव्यक्ति दूसरे प्राणियों तक पहंुचाने में सामथ्र्यशाली होता है। रूप को मनुष्य भिन्न-भिन्न तरह से दृष्टिगत रूप देता है, परन्तु इसमें रंग संयोजन का प्रयोग कर, इसे ऊर्जावान बनाता है।
COLOR, HEALTH, VEGETABLES - AN APPROACH
Authors: Srivastava Pratibha
Published: March 2021

Colors have great importance in our lives. Through them we get to know the conditions around us and know the effect of colors. Colors arise from the spectral activities when they meet the spectrum in the human eye. Originally, only seven colors of the rainbow are considered to be the father of colors. These seven colors are red, orange, yellow, green, sky, blue and purple. Human virtue religion has red, blue and green colors according to the virtual perception. Different types of objects, sources and categories etc. come from colors. The physical, properties of light sources such as light villian, inclusion, reflection, etc. are associated with which color combinations are known.

रंगों का हमारे जीवन में बहुत महत्व है। इनके द्वारा हमें अपने चारों ओर की स्थितियों का ज्ञान होता है और रंगों का प्रभाव ज्ञात होता है। रंग मनुष्य की आँख में वर्णक्रम से मिलने पर छाया संबंधी गतिविधियों से उत्पन्न होते है। मूलरूप से इन्द्रधनुष के सात रंगों को ही रंगों का जनक माना जाता है। ये सात रंग लाल, नारंगी, पीला, हरा, आसमानी, नीला व बैंगनी है। मानवीय गुण धर्म में आभासी बोध के अनुसार लाल, नीला व हरा रंग होता है। रंगों से विभिन्न प्रकार से वस्तु प्रकाष स्त्रोत एवं श्रेणियां इत्यादि आती है। प्रकाष स्त्रोतोें के भौतिक, गुणधर्म जैसे प्रकाष विलियन, समावेषन, परावर्तन, इत्यादि जुड़े है, जिनसे रंग संयोजन ज्ञात होते है।
IMPACT OF GLOBALIZATION ON PAINTING
Authors: Sharma Archana
Published: March 2021

Art plays an important role in the development of any country. Art is considered a medium for realizing beauty or prosperity. Architecture, sculpture, painting and music have been considered under fine arts. Both painting or poetry is a means of expressing the inner feelings of man. Today in painting, it is possible that even if color does not make sense, it can reach the mind directly and make you feel happy. Art is said to be a response to the realization of truth. By combining Rupo in pictures, the eyes get satiety. Through the eyes, there is a cook in different minds in the mind of the audience.

किसी भी देष के विकास में कला का महत्वपुर्ण योगदान होता है। कला को सोन्दर्य अथवा समृद्वि को साकार करने का माध्यम माना गया है। वास्तुकला, मूर्ति कला, चित्रकला तथा संगीत को ललित कला के अन्तर्गत माना गया है। चित्रकला हो या कविता दोनो ही मनुष्य की आंतरिक भावनाओं को व्यक्त करने का एक माध्यम है। चित्रकला में आज ऐसा संभव है कि रंग का अर्थ न निकले फिर भी वह सीधे मन तक पहुॅच कर रसानुभूति करा सकता है। कला को सत्य की अनुभूति की अनुक्रति कहा गया है। चित्रो में रूपो के संयोजन से नेत्रो को तृप्ति मिलती है। आंखो के माध्यम से दर्षक के मन में विभिन्न भावो से रसोदे्रक होता है।