bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between tightness of the hip joint and shoulder/elbow injury in high school baseball pitchers: a prospective study
Authors: Hamano Noritaka , Shitara Hitoshi , Tajika Tsuyoshi , Ichinose Tsuyoshi , Sasaki Tsuyoshi , Kamiyama Masataka , Miyamoto Ryosuke , Kuboi Takuro , Endo Fumitaka , Yamamoto Atsushi , Takagishi Kenji , Chikuda Hirotaka
Published: November 2020

Some studies have reported that upper limb tightness is a risk factor for shoulder/elbow pain in high school baseball pitchers; but there has been insufficient research on the relationship between lower limb tightness and shoulder and elbow pain in pitchers. This study aimed to clarify the correlation among pre-season hip range of motion (ROM) and shoulder and elbow disorders in high school baseball pitchers. We surveyed 125 high school pitchers. Hip ROM was measured in the supine and prone positions. After the season, based on their answers to the self-recorded questionnaire, a “shoulder or elbow injury” was defined as any condition resulting in the pitcher being considered disabled for ≥ 8 days. An independent t-test and logistic regression analysis were used for statistical analysis. Eleven disabled pitchers (9%) were identified during the season. In the injured group, the ROM of the plant side hip with 90° flexed external rotation was smaller than that in the non-injured group. Preseason limited ROM in the plant side hip with 90° flexed external rotation was a risk factor for the occurrence of shoulder/elbow pain in the season.
Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo
Authors: Tan Shirui , Gao Jing , Li Qingrong , Guo Tieying , Dong Xiangshu , Bai Xuehui , Yang Jinghui , Hao Shumei , He Feifei
Published: November 2020

The study aimed to investigate the antibacterial effect and potential mechanisms of chlorogenic acid (CA) in Klebsiella pneumonia (KPN) induced infection in vitro and in vivo. 62 KPN strains were collected from the First People’s Hospital of Yunnan Province. CA and CA combined Levofloxacin (LFX) were detected for KPN biofilm (BF) formation in vitro. The lung infection mice model were established by KPN. The effect of CA (500 mg/kg), LFX (50 mg/kg) and CA combined LFX (250 mg/kg + 25 mg/kg) were evaluated through the survival of mice, the changes of inflammation factors of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6 in serum, the histopathological analysis of lung and the protein expression of NLRP3 signaling pathway in vivo. A total of 62 KPNs were isolated and identified, of which 13 (21%) strains were BF positive. 8 (13%) strains were extended spectrum β-lactamase strains (ESBLs), and 20 (32%) strains are ESBLs biofilm positive. In vitro study, CA and LFX showed a synergistic effect on KPN biofilm formation. In vivo mice experiment, CA, especially CA + LFX treated group significantly decreased the serum levels of TNF-α, IL-1β and IL-6, improved the survival ratio and lung pathology changes, and also reduced the protein expression of ASC, caspase 1 p20, IL-1β and phosphor NF-κB p65. CA could effectively alleviate lung infection of KPN infected mice, and the antibacterial effection is strengthened by combined with LFX. The study provide a theroy basis for making rational and scientific antibacterial therapy strategy in clinic.
Longevity strategies in response to light in the reef coral Stylophora pistillata
Authors: Ottaviani Alexandre , Eid Rita , Zoccola Didier , Pousse Mélanie , Dubal Jean-Marc , Barajas Edwige , Jamet Karine , Lebrigand Kevin , Lapébie Pascal , Baudoin Christian , Giraud-Panis Marie-Josèphe , Rouan Alice , Beauchef Gallic , Guéré Christelle , Vié Katell , Barbry Pascal , Tambutté Sylvie , Gilson Eric , Allemand Denis
Published: November 2020

Aging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development of a large array of age-related diseases. Evidence suggests that the accumulation of senescent cells in tissue promotes both normal and pathological aging. Oxic stress is a key driver of cellular senescence. Because symbiotic long-lived reef corals experience daily hyperoxic and hypoxic transitions, we hypothesized that these long-lived animals have developed specific longevity strategies in response to light. We analyzed transcriptome variation in the reef coralStylophora pistillataduring the day–night cycle and revealed a signature of the FoxO longevity pathway. We confirmed this pathway by immunofluorescence using antibodies against coral FoxO to demonstrate its nuclear translocation. Through qPCR analysis of nycthemeral variations of candidate genes under different light regimens, we found that, among genes that were specifically up- or downregulated upon exposure to light, human orthologs of two “light-up” genes (HEY1 and LONF3) exhibited anti-senescence properties in primary human fibroblasts. Therefore, these genes are interesting candidates for counteracting skin aging. We propose a large screen for other light-up genes and an investigation of the biological response of reef corals to light (e.g., metabolic switching) to elucidate these processes and identify effective interventions for promoting healthy aging in humans.
Identification of species-specific peptide markers in cold-pressed oils
Authors: Kotecka-Majchrzak Klaudia , Sumara Agata , Fornal Emilia , Montowska Magdalena
Published: November 2020

In recent years, cold-pressed vegetable oils have become very popular on the global market. Therefore, new versatile methods with high sensitivity and specificity are needed to find and combat fraudulent practices. The objective of this study was to identify oilseed species-specific peptide markers, using proteomic techniques, for authentication of 10 cold-pressed oils. In total, over 380 proteins and 1050 peptides were detected in the samples. Among those peptides, 92 were found to be species-specific and unique to coconut, evening primrose, flax, hemp, milk thistle, nigella, pumpkin, rapeseed, sesame, and sunflower oilseed species. Most of the specific peptides were released from major seed storage proteins (11 globulins, 2S albumins), and oleosins. Additionally, the presence of allergenic proteins in the cold-pressed oils, including pumpkin Cuc ma 5, sunflower Hel a 3, and six sesame allergens (Ses i 1, Ses i 2, Ses i 3, Ses i 4, Ses i 6, and Ses i 7) was confirmed in this study. This study provides novel information on specific peptides that will help to monitor and verify the declared composition of cold-pressed oil as well as the presence of food allergens. This study can be useful in the era of widely used unlawful practices.
Electrode and dielectric layer interface device engineering study using furan flanked diketopyrrolopyrrole–dithienothiophene polymer based organic transistors
Authors: Patil Basanagouda. B. , Takeda Yasunori , Singh Subhash , Wang Tony , Singh Amandeep , Do Thu Trang , Singh Samarendra P. , Tokito Shizuo , Pandey Ajay K. , Sonar Prashant
Published: November 2020

We successfully demonstrated a detailed and systematic enhancement of organic field effect transistors (OFETs) performance using dithienothiophene (DTT) and furan-flanked diketopyrrolopyrrole based donor–acceptor conjugated polymer semiconductor namely PDPPF-DTT as an active semiconductor. The self-assembled monolayers (SAMs) treatments at interface junctions of the semiconductor–dielectric and at the semiconductor–metal electrodes has been implemented using bottom gate bottom contact device geometry. Due to SAM treatment at the interface using tailored approach, the significant reduction of threshold voltage (Vth) from − 15.42 to + 5.74 V has been observed. In addition to tuning effect of Vth, simultaneously charge carrier mobility (µFET) has been also enhanced the from 9.94 × 10−4 cm2/Vs to 0.18 cm2/Vs. In order to calculate the trap density in each OFET device, the hysteresis in transfer characteristics has been studied in detail for bare and SAM treated devices. Higher trap density in Penta-fluoro-benzene-thiol (PFBT) treated OFET devices enhances the gate field, which in turn controls the charge carrier density in the channel, and hence gives lower Vth = + 5.74 V. Also, PFBT treatment enhances the trapped interface electrons, which helps to enhance the mobility in this OFET architecture. The overall effect has led to possibility of reduction in the Vth with simultaneous enhancements of µFET in OFETs, following systematic device engineering methodology.
Isoflavones, anthocyanins, phenolic content, and antioxidant activities of black soybeans (Glycine max (L.) Merrill) as affected by seed weight
Authors: Choi Yu-Mi , Yoon Hyemyeong , Lee Sukyeung , Ko Ho-Cheol , Shin Myoung-Jae , Lee Myung Chul , Hur On Sook , Ro Na Young , Desta Kebede Taye
Published: November 2020

Seed weight is regulated by several genes which in turn could affect the metabolite contents, yield, and quality of soybean seeds. Due to these, seed weight is receiving much attention in soybean breeding. In this study, seeds of 24 black soybean varieties and a reference genotype were grown in Korea, and grouped as small (< 13 g), medium (13–24 g), and large (> 24 g) seeds based on their seed weight. The contents of six anthocyanins, twelve isoflavones, and total phenolic, and the antioxidant activities were determined, and the association of each with seed weight was analyzed. The total anthocyanin (TAC) and total isoflavone (TIC) contents were in the ranges of 189.461–2633.454 mg/100 g and 2.110–5.777 mg/g, respectively and were significantly different among the black soybean varieties. By comparison, the average TAC and TIC were the highest in large seeds than in small and medium seeds while the total phenolic content (TPC) was in the order of small seeds > large seeds > medium seeds. Besides, large seeds showed the maximum 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, whereas small seeds showed the maximum ferric reducing antioxidant power (FRAP) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS) scavenging activities. FRAP activity was positively associated with TIC and TAC, the former association being significant. On the other hand, ABTS and DPPH activities were positively correlated to TPC, the later association being significant. Overall, our findings demonstrated the influence of seed weight on anthocyanin, isoflavone, and phenolic contents and antioxidant activities in black soybeans. Besides, the dominant anthocyanins and isoflavones were the principal contributors to the variations observed in the black soybean varieties, and hence, these components could be selectively targeted to discriminate a large population of black soybean genetic resources.
Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia
Authors: Tessema Sofonias K. , Belachew Mulualem , Koepfli Cristian , Lanke Kjerstin , Huwe Tiffany , Chali Wakweya , Shumie Girma , Mekuria Elias F. , Drakeley Chris , Gadisa Endalamaw , Greenhouse Bryan , Bousema Teun , Tadesse Fitsum G.
Published: November 2020

The distribution of malaria infections is heterogeneous in space and time, especially in low transmission settings. Understanding this clustering may allow identification and targeting of pockets of transmission. In Adama district, Ethiopia, Plasmodium falciparum and P. vivax malaria patients and controls were examined, together with household members and immediate neighbors. Rapid diagnostic test and quantitative PCR (qPCR) were used for the detection of infections that were genetically characterized by a panel of microsatellite loci for P. falciparum (26) and P. vivax (11), respectively. Individuals living in households of clinical P. falciparum patients were more likely to have qPCR detected P. falciparum infections (22.0%, 9/41) compared to individuals in control households (8.7%, 37/426; odds ratio, 2.9; 95% confidence interval, 1.3–6.4; P = .007). Genetically related P. falciparum, but not P. vivax infections showed strong clustering within households. Genotyping revealed a marked temporal cluster of P. falciparum infections, almost exclusively comprised of clinical cases. These findings uncover previously unappreciated transmission dynamics and support a rational approach to reactive case detection strategies for P. falciparum in Ethiopia.
The Skytrain plate and tectonic evolution of southwest Gondwana since Jurassic times
Authors: Eagles Graeme , Eisermann Hannes
Published: November 2020

Uncertainty about the structure of the Falkland Plateau Basin has long hindered understanding of tectonic evolution in southwest Gondwana. New aeromagnetic data from the basin reveal Jurassic-onset seafloor spreading by motion of a single newly-recognized plate, Skytrain, which also governed continental extension in the Weddell Sea Embayment and possibly further afield in Antarctica. The Skytrain plate resolves a nearly century-old controversy by requiring a South American setting for the Falkland Islands in Gondwana. The Skytrain plate’s later motion provides a unifying context for post-Cambrian wide-angle paleomagnetic rotation, Cretaceous uplift, and post-Permian oblique collision in the Ellsworth Mountains of Antarctica. Further north, the Skytrain plate’s margins built a continuous conjugate ocean to the Weddell Sea in the Falkland Plateau Basin and central Scotia Sea. This ocean rules out venerable correlation-based interpretations for a Pacific margin location and subsequent long-distance translation of the South Georgia microcontinent as the Drake Passage gateway opened.
Clinical factors associated with prognosis in low-grade serous ovarian carcinoma: experiences at two large academic institutions in Korea and Taiwan
Authors: Kang Jun-Hyeok , Lai Yen-Ling , Cheng Wen-Fang , Kim Hyun-Soo , Kuo Kuan-Ting , Chen Yu-Li , Lee Yoo-Young
Published: November 2020

Low-grade ovarian serous carcinoma (LGSOC) has clinical features different from high-grade serous ovarian carcinoma (HGSOC) accounting for the majority of epithelial ovarian cancer. Because of its rarity, previous studies have only focused on the high-grade disease without considering the differences between the two subtypes. This study aimed to evaluate the effect of the clinical prognostic factors known for HGSOC on survival in patients with LGSOC. Based on the Federation of Gynecology and Obstetrics (FIGO) stage, progression-free survival (PFS) was markedly decreased in advanced disease compared with early disease. For stage I, patients with stage IC had poorer survival than those with stage IA and IB regardless of the number of cycles of adjuvant chemotherapy. For advanced disease, no gross residual disease after primary cytoreductive surgery was significantly associated with longer PFS when compared with gross residual disease. In multivariate analysis for PFS and overall survival (OS), age, preoperative CA-125, time interval from surgery to chemotherapy, and the number of cycles of adjuvant chemotherapy were not associated with prognosis. Complete cytoreduction was the only independent prognostic factor for PFS (HR 2.45, p = 0.045). Our study revealed that the known prognostic factors in HGSOC did not show any effect on the survival in LGSOC except for FIGO stage and complete cytoreduction.
High-temperature etching of SiC in SF6/O2 inductively coupled plasma
Authors: Osipov Artem A. , Iankevich Gleb A. , Speshilova Anastasia B. , Osipov Armenak A. , Endiiarova Ekaterina V. , Berezenko Vladimir I. , Tyurikova Irina A. , Tyurikov Kirill S. , Alexandrov Sergey E.
Published: November 2020

In this work, we demonstrate an effective way of deep (30 µm depth), highly oriented (90° sidewall angle) structures formation with sub-nanometer surface roughness (Rms = 0.7 nm) in silicon carbide (SiC). These structures were obtained by dry etching in SF6/O2 inductively coupled plasma (ICP) at increased substrate holder temperatures. It was shown that change in the temperature of the substrate holder in the range from 100 to 300 °C leads to a sharp decrease in the root mean square roughness from 153 to 0.7 nm. Along with this, it has been established that the etching rate of SiC also depends on the temperature of the substrate holder and reaches its maximum (1.28 µm/min) at temperatures close to 150 °C. Further temperature increase to 300 °C does not lead to the etching rate rising. The comparison of the results of the thermally stimulated process and the etching with a water-cooled substrate holder (15 °C) is carried out. Plasma optical emission spectroscopy was carried out at different temperatures of the substrate holder.
Operant conditioning of motor cortex neurons reveals neuron-subtype-specific responses in a brain-machine interface task
Authors: Garcia-Garcia Martha Gabriela , Marquez-Chin Cesar , Popovic Milos R.
Published: November 2020

Operant conditioning is implemented in brain-machine interfaces (BMI) to induce rapid volitional modulation of single neuron activity to control arbitrary mappings with an external actuator. However, intrinsic factors of the volitional controller (i.e. the brain) or the output stage (i.e. individual neurons) might hinder performance of BMIs with more complex mappings between hundreds of neurons and actuators with multiple degrees of freedom. Improved performance might be achieved by studying these intrinsic factors in the context of BMI control. In this study, we investigated how neuron subtypes respond and adapt to a given BMI task. We conditioned single cortical neurons in a BMI task. Recorded neurons were classified into bursting and non-bursting subtypes based on their spike-train autocorrelation. Both neuron subtypes had similar improvement in performance and change in average firing rate. However, in bursting neurons, the activity leading up to a reward increased progressively throughout conditioning, while the response of non-bursting neurons did not change during conditioning. These results highlight the need to characterize neuron-subtype-specific responses in a variety of tasks, which might ultimately inform the design and implementation of BMIs.
Carbonization and H3PO4 activation of fern Dicranopteris linearis and electrochemical properties for electric double layer capacitor electrode
Authors: Trinh Trang K. , Tsubota Toshiki , Takahashi Shuto , Mai Nga T. , Nguyen Minh N. , Nguyen Nam H.
Published: November 2020

Today, the world’s climate change is a growing problem, plant carbon sequestration is one of the effective ways to mitigate climate change by reducing greenhouse gases, mostly carbon gases. Dicranopteris linearis (D. linearis), a common fern species in the tropic or subtropic ecoregions, has been recently recognized as a potential feedstock to produce highly porous biochar. This study aims to enhance the specific surface area (SSA) and pore volumes of biochars derived from the D. linearis by H3PO4 activation and examine electrical properties of the activated biochars and their possible usage for the electric double-layer capacitor (EDLC) electrode. The treated raw fern was activated with H3PO4 85% by the three different mixing ratios 1:0, 1:1, and 1:3 (w/w) and then pyrolysis under N2 flow maintained at 500 °C for 1 h. The performance as the electrode for an EDLC was evaluated in 1 mol L−1 H2SO4 solution for the H3PO4-activated samples. The SSA and pore volumes were drastically increased after activation. The maximum SSA and pore volume were 1212 m2 g−1 and 1.43 cm3 g−1, respectively for the biochar activated at 400 °C with a weight mixing ratio 1:3 (w/w) between the fern and H3PO4 acid while these values of the biochar at 400 °C were 12 m2 g−1 and 0.02 cm3 g−1, respectively. The biochar activated at 600 °C with the mixing ratio 1:1 (w/w) showed the maximum capacitance value, ca. 108 F g−1 at 1 mV s−1. The activation using H3PO4 showed a positive tendency to enhance electrochemical properties and it could be a premise toward a higher performance of EDLC from the D. linearis derived activated biochar.
Quantitative analysis of low-concentration α-HMX based on terahertz spectroscopy
Authors: Tang Zhengmin , Deng Hu , Liu Quancheng , Guo Jin , Shang Liping
Published: November 2020

Due to the instability of α type HMX at low concentrations, it belongs to the impurity crystal form.
Positively charged gold–silver nanostar enabled molecular characterization of cancer associated extracellular vesicles
Authors: Liu Yuan , Zhang Wei , Phan Thanh Huyen , Chrzanowski Wojciech , Rodger Alison , Wang Yuling
Published: November 2020

Direct surface-enhanced Raman scattering (SERS) has contributed to characterizing extracellular vesicles (EVs) by providing molecular signatures.
A vaccine for photodynamic immunogenic cell death: tumor cell caged by cellular disulfide–thiol exchange for immunotherapy
Authors: Wen Ya , Liu Yiqiong , Guo Fangfang , Han Yi , Qiu Qiansai , Li Yan , Dong Haiqing , Ren Tianbin , Li Yongyong
Published: November 2020

Tumor cells, caged by the protein shell, are mediated to an immunogenic cell death and transformed into a hot cell vaccine. Such vaccine protects 75% pre-immunized mice against tumor initiation and significantly retards the established tumor growth.
Fenton-like reaction, glutathione reduction, and photothermal ablation-built-in hydrogels crosslinked by cupric sulfate for loco-regional cancer therapy
Authors: Kim Sungyun , Seo Ji-Hye , Jeong Da In , Yang Mingyu , Lee Song Yi , Lee Junmin , Cho Hyun-Jong
Published: November 2020

CuSO4-reinforced hydrogel system was developed for chemodynamic and photothermal therapy of breast cancer.
pH-Sensitive nanogels for drug delivery in cancer therapy
Authors: Li Zhen , Huang Jun , Wu Jun
Published: November 2020

Compared to normal tissue, solid tumors exhibit a lower pH value. Such pH gradient can be used to design pH-sensitive nanogels for selective drug delivery. The acid-sensitive elements in the nanogel cause it to swell/degrade rapidly, followed by rapid drug release.
Enhanced proton conductivity in a flexible metal–organic framework promoted by single-crystal-to-single-crystal transformation
Authors: Chen Xi , Zhang Zhongyue , Chen Jin , Sapchenko Sergei , Han Xue , da-Silva Ivan , Li Ming , Vitorica-Yrezabal Inigo J. , Whitehead George , Tang Chiu C. , Awaga Kunio , Yang Sihai , Schröder Martin
Published: November 2020

Transformation of MFM-722(Pb)-DMA to MFM-722(Pb)-H2O leads to an increase in proton conductivity linked to a structural transition.
Promoting the electrocatalytic properties of nickel aerogel by gold decoration for efficient electrocatalytic oxygen evolution in alkali
Authors: Gao Wei , Lei Min , Li Lanqing , Wen Dan
Published: November 2020

Decoration of Au onto Ni aerogel preserved the structural features and modulated their interaction to enhance the OER electrocatalytic properties.
Evaluating the role of a urea-like motif in enhancing the thermal and mechanical strength of supramolecular gels
Authors: Tómasson Daníel Arnar , Ghosh Dipankar , Kurup M. R. Prathapachandra , Mulvee Matthew T. , Damodaran Krishna K.
Published: November 2020

Enhanced thermal and mechanical strength in semicarbazone gels with a urea-like motif obtained by modifying the hydrogen bonding motif of the hydrazone compound.
(De)lithiation of spinel ferrites Fe3O4, MgFe2O4, and ZnFe2O4: a combined spectroscopic, diffraction and theory study
Authors: Bock David C. , Tallman Killian R. , Guo Haoyue , Quilty Calvin , Yan Shan , Smith Paul F. , Zhang Bingjie , Lutz Diana M. , McCarthy Alison H. , Huie Matthew M. , Burnett Veronica , Bruck Andrea M. , Marschilok Amy C. , Takeuchi Esther S. , Liu Ping , Takeuchi Kenneth J.
Published: November 2020

Combined X-ray absorption spectroscopy, synchrotron X-ray diffraction, and density functional theory elucidate (de)lithiation mechanisms for the spinel ferrites MFe2O4 (M = Fe2+, Mg2+, Zn2+).
Preferential location of zirconium dopants in cerium dioxide nanoparticles and the effects of doping on their reducibility: a DFT study
Authors: Koleva Iskra Z. , Aleksandrov Hristiyan A. , Neyman Konstantin M. , Vayssilov Georgi N.
Published: November 2020

Zirconium doping dramatically facilitates O vacancy formation in ceria nanoparticles not only at the surface but also in four-coordinated inner O positions, which enhances O mobility. In mixed nanoparticles zirconium tends to occupy inner sites.
Solar and visible-light active nano Ni/g-C3N4 photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions
Authors: Hosseini-Sarvari Mona , Akrami Zahra
Published: November 2020

In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands.
Ionic liquid induced highly dense assembly of porphyrin in MOF nanosheets for photodynamic therapy
Authors: Qin Jian-Hua , Zhang Hua , Sun Pengfei , Huang Ya-Dan , Shen Qingming , Yang Xiao-Gang , Ma Lu-Fang
Published: November 2020

A facile fabrication of porphyrin-integrated MOF nanosheets as efficient photosensitizers for photodynamic therapy (PDT) is presented.
Dendrite-free Zn anodes enabled by functional nitrogen-doped carbon protective layers for aqueous zinc-ion batteries
Authors: Wu Cuiping , Xie Kaixuan , Ren Kaixin , Yang Shun , Wang Qinghong
Published: November 2020

A nitrogen-doped carbon network coating layer on zinc foil effectively hampers the growth of Zn dendrites and buffers the side reaction of corrosion, thus improving the cycling stability of the Zn anode.
Black bean protein concentrate ameliorates hepatic steatosis by decreasing lipogenesis and increasing fatty acid oxidation in rats fed a high fat-sucrose diet
Authors: Hernandez-Velazquez Irma , Sanchez-Tapia Monica , Ordaz-Nava Guillermo , Torres Nimbe , Tovar Armando R. , Galvez Amanda
Published: November 2020

The black bean is a legume widely consumed in Latin America, however its consumption has decreased significantly in recent decades.
Thermal and non-thermal processing of red-fleshed apple: how are (poly)phenol composition and bioavailability affected?
Authors: Yuste Silvia , Macià Alba , Motilva María-José , Prieto-Diez Neus , Romero María-Paz , Pedret Anna , Solà Rosa , Ludwig Iziar A. , Rubió Laura
Published: November 2020

This work fills a gap in the understanding of the effect of processing on the bioavailability of (poly)phenols in fruit products.
Dietary probiotic and metabolites improve intestinal homeostasis and prevent colorectal cancer
Authors: Peng Mengfei , Lee Seong-Ho , Rahaman Shaik O. , Biswas Debabrata
Published: November 2020

Metabolites from Lactobacillus casei display substantial antioxidant and anti-inflammatory activities, inhibit colorectal cancer cell proliferation and growth, and modulate gut microfloral composition, specifically reducing sulfidogenic bacteria.
New ternary deep eutectic solvents for effective wheat straw deconstruction into its high-value utilization under near-neutral conditions
Authors: Ci Yu-hui , Yu Fei , Zhou Cheng-xuan , Mo Hao-e , Li Zu-yu , Ma Yun-qian , Zang Li-hua
Published: November 2020

The new synthesized DES is used to reduce, which significantly reduces the maintenance cost of biomass refining equipment and provides a feasible way for biomass resource utilization under near-neutral conditions.
Metallotherapeutics development in the age of iron-clad bacteria
Authors: Centola Garrick , Xue Fengtian , Wilks Angela
Published: November 2020

Drug-resistant infections pose a significant risk to global health as pathogenic bacteria become increasingly difficult to treat. The rapid selection of resistant strains through poor antibiotic stewardship has reduced the number of viable treatments and increased morbidity of infections, especially among the immunocompromised. To circumvent such challenges, new strategies are required to stay ahead of emerging resistance trends, yet research and funding for antibiotic development lags other classes of therapeutics. Though the use of metals in therapeutics has been around for centuries, recent strategies have devoted a great deal of effort into the pathways through which bacteria acquire and utilize iron, which is critical for the establishment of infection. To target iron uptake systems, siderophore–drug conjugates have been developed that hijack siderophore-based iron uptake for delivery of antibiotics. While this strategy has produced several potential leads, the use of siderophores in infection is diminished over time when bacteria adapt to utilize heme as an iron source, leading to a need for the development of porphyrin mimetics as therapeutics. The use of such strategies as well as the inclusion of gallium, a redox-inert iron mimic, are herein reviewed.
Structure–activity relationship analysis of a series of nonsteroidal analogues as androgen receptor antagonists
Authors: Yuan Miao , Cheng Ping , Zhang Shuping
Published: November 2020

Computer-aided drug design technology was used to screen drugs in large-scale and to accelerate the progress of drug design of nonsteroidal compounds deriving from the hybridization of FDA-approved Enzalutamide and Abiraterone.
Drug design and molecular docking simulations of Polo-like kinase 1 inhibitors based on QSAR study
Authors: Tong Jianbo , Wang Tianhao , Feng Yi
Published: November 2020

Computationally exploring novel potential Polo-like kinase 1 inhibitors using a systematic modeling study.
Annulation of imidazo[1,2-a]pyridines under metal-free conditions
Authors: Semwal Rashmi , Joshi Abhisek , Kumar Rahul , Adimurthy Subbarayappa
Published: November 2020

Synthesis of benzo[a]imidazo[5,1,2-cd]indolizines from 2-arylimidazo[1,2-a]pyridines and benzyne precursors under metal-free conditions has been described.
Enhanced structural and magnetic properties of fcc colloidal crystals of cobalt nanoparticles
Authors: Costanzo S. , Ngo A. T. , Russier V. , Albouy P. A. , Simon G. , Colomban Ph. , Salzemann C. , Richardi J. , Lisiecki I.
Published: November 2020

We report the elaboration of supercrystals made up of dodecanoic acid-coated 8.1 nm-Co nanocrystals with controlled supercrystallinity, morphology and magnetic properties.
Selective extracellular arginine deprivation by a single injection of cellular non-uptake arginine deiminase nanocapsules for sustained tumor inhibition
Authors: Qi Hongzhao , Wang Yin , Yuan Xubo , Li Peifeng , Yang Lijun
Published: November 2020

Arginine deiminase nanocapsules possessing extremely weak cellular interaction could selectively deprive extracellular arginine to treat argininosuccinate synthetase-deficient tumors efficiently.
Intramolecular [3 + 2] nitrone cycloaddition reaction: highly regio and diastereoselective synthesis of bicyclo[3.2.1]octane scaffolds
Authors: Bakthadoss Manickam , Mushaf Mohammad
Published: November 2020

Development of a regio- and a diastereoselective protocol for the synthesis of bicyclo[3.2.1]octane frameworks from vinylogous carbonates and N-substituted hydroxylamine hydrochlorides via intramolecular 1,3-dipolar nitrone cycloaddition reaction.
Structural isomers of saligenin-based β2-agonists: synthesis and insight into the reaction mechanism
Authors: Knežević Anamarija , Novak Jurica , Bosak Anita , Vinković Marijana
Published: November 2020

The unexpected emergence of β-aryl-β-aminoethanol isomers in the reaction between aromatic β-halohydrin and amines was analyzed by experimental and computational methods.
Imine-functionalized polysiloxanes for supramolecular elastomers with tunable mechanical properties
Authors: Hu Han , Wang Linlin , Wang Lili , Li Lei , Feng Shengyu
Published: November 2020

A series of imine-functionalized polysiloxanes were reported for the first time and used to build supramolecular coordination elastomers.
Thermo- and oxidation-sensitive poly(meth)acrylates based on alkyl sulfoxides: dual-responsive homopolymers from one functional group
Authors: Işık Doğuş , Quaas Elisa , Klinger Daniel
Published: November 2020

Alkyl sulfoxide side groups introduce thermo- and oxidation-sensitivity into poly(meth)acrylates, thus realizing new dual-responsive homopolymers based on one functional group.
Progress in the synthesis of imide-based N-type polymer semiconductor materials
Authors: Liao Mao , Duan Jieming , Peng Peng'ao , Zhang Jingfeng , Zhou Ming
Published: November 2020

Representative molecular structures of four N-type polymer semiconductors materials (a: N2000; b: PPDI-DTT, c: TBDI-DT and d: PDTzTIT) based on NDI, PDI, BTI and BTzI, respectively.
SiC mesoporous membranes for sulfuric acid decomposition at high temperatures in the iodine–sulfur process
Authors: Yu Xin , Wang Qing , Nagasawa Hiroki , Kanezashi Masakoto , Tsuru Toshinori
Published: November 2020

In the present study, SiC particles derived mesoporous membrane was discovered and applied to membrane reactor for H2SO4 decomposition. The reaction equilibrium was moved the to the product side by membrane reactor with extraction at 600 °C.
Elaboration of soft porous ultrasound insulators
Authors: Poupart Romain , Lacour Thomas , Darnige Pablo , Poncelet Olivier , Aristégui Christophe , Voisin Thomas , Marre Samuel , Brunet Thomas , Mondain-Monval Olivier
Published: November 2020

A simple and easy way is proposed for the fabrication of a highly attenuating composite material for underwater acoustics.
A functional modified graphene oxide/nanodiamond/nano zinc oxide composite for excellent vulcanization properties of natural rubber
Authors: Yang Zhen , Huang Yan , Xiong Yuzhu
Published: November 2020

A modified graphene oxide/nanodiamond/nanozinc oxide (MGO/ND/nanoZnO) functional hybrid filler is designed and prepared to improve the vulcanization efficiency of a rubber composite and to reduce the use of ZnO.
Electronic and structural characterisation of polycrystalline platinum disulfide thin films
Authors: Zhussupbekov Kuanysh , Cullen Conor P. , Zhussupbekova Ainur , Shvets Igor V. , Duesberg Georg S. , McEvoy Niall , Ó Coileáin Cormac
Published: November 2020

Semiconducting thin-film polycrystalline PtS2 is characterised by atomically resolved scanning tunnelling microscopy and spectroscopy.
A useful preparation of ultrasmall iron oxide particles by using arc plasma deposition
Authors: Ida Yumi , Okazawa Atsushi , Sonobe Kazutaka , Muramatsu Hisanori , Kambe Tetsuya , Imaoka Takane , Chun Wang-Jae , Tanabe Makoto , Yamamoto Kimihisa
Published: November 2020

Finely size-controlled ultrasmall iron oxide particles (IOPs) on graphene nanosheets were usefully prepared by using pulsed arc plasma deposition. The IOPs are composed of a high crystallinity single γ-Fe2O3 component without annealing.
Ruddlesden–Popper phases of lithium-hydroxide-halide antiperovskites: two dimensional Li-ion conductors
Authors: Koedtruad Anucha , Amano Patino Midori , Chuang Yu-Chun , Chen Wei-tin , Kan Daisuke , Shimakawa Yuichi
Published: November 2020

Then= 2 Ruddlesden–Popper antiperovskite LiBr(Li2OHBr)2was successfully obtained and the two-dimensional Li-ion conduction was discussed.
Pre-oxidization-induced change of physicochemical characteristics and removal behaviours in conventional drinking water treatment processes for polyethylene microplastics
Authors: Shao Yu , Zhou Xinhong , Liu Xiaowei , Wang Lili
Published: November 2020

This study revealed whether the conventional pre-oxidization processes in drinking water treatment can affect PE MPs′ physicochemical characteristics and their removal behavior in the subsequent drinking water treatment processes.
Influence of Al3+co-doping on the spectral properties of europium doped Ca9Y(PO4)7
Authors: Szczodrowski Karol , Górecka Natalia , Grinberg Marek
Published: November 2020

A series of luminescent materials based on a calcium yttrium phosphate matrix doped with europium and different concentrations of aluminum ions (0, 5, 10% of mole) was synthesized using the Pechini method.
Carboxylated cellulose nanofiber/montmorillonite nanocomposite for the removal of levofloxacin hydrochloride antibiotic from aqueous solutions
Authors: Li Junfeng , Tao Junhong , Ma Chengxiao , Yang Jie , Gu Tiantian , Liu Jianchao
Published: November 2020

Herein, we report the facile two-step synthesis of an effective carboxylated cellulose nanofiber/montmorillonite nanocomposite (CMNFs–MMT) adsorbent for levofloxacin hydrochloride (Levo-HCl).
NiSe2/CdS composite nanoflakes photocatalyst with enhanced activity under visible light
Authors: Shen Shijie , Yan Linghui , Song Kai , Lin Zhiping , Wang Zongpeng , Du Daming , Zhang Huanhuan
Published: November 2020

The obtained NiSe2/CdS composite nanoflakes exhibit greatly enhanced photocatalytic properties due to the accelerated separation of photon-generated carriers.
Supramolecular adducts between macrocyclic Gd(iii) complexes and polyaromatic systems: a route to enhance the relaxivity through the formation of hydrophobic interactions
Authors: Di Gregorio Enza , Lattuada Luciano , Maiocchi Alessandro , Aime Silvio , Ferrauto Giuseppe , Gianolio Eliana
Published: November 2020

The set-up of reversible binding interactions between the hydrophobic region of macrocyclic gadolinium based contrast agents and SO3−/OH containing pyrene derivatives provides new insights for pursuing relaxivity enhancement of MRI contrast agents.
Influence of structure and solubility of chain transfer agents on the RAFT control of dispersion polymerisation in scCO2
Authors: Pacheco Ana A. C. , da Silva Filho Arnaldo F. , Kortsen Kristoffer , Hanson-Heine Magnus W. D. , Taresco Vincenzo , Hirst Jonathan D. , Lansalot Muriel , D'Agosto Franck , Howdle Steven M.
Published: November 2020

RAFT dispersion polymerisation of methyl methacrylate is performed in scCO2 with 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT) present as chain transfer agent (CTA) and surprisingly shows good control over PMMA molecular weight.
Light-fueled dynamic covalent crosslinking of single polymer chains in non-equilibrium states
Authors: Kodura Daniel , Houck Hannes A. , Bloesser Fabian R. , Goldmann Anja S. , Du Prez Filip E. , Frisch Hendrik , Barner-Kowollik Christopher
Published: November 2020

Synthetic polymers consume green light as fuel for intramolecular crosslinking, yielding non-equilibrium single chain nanoparticles that can be light-stabilised, kinetically and chemically trapped, or else unfold in the absence of light fuel.
Ion type and valency differentially drive vimentin tetramers into intermediate filaments or higher order assemblies
Authors: Denz Manuela , Marschall Manuel , Herrmann Harald , Köster Sarah
Published: November 2020

Our systematic study shows that vimentin forms individual 10 nm diameter filaments in the presence of monovalent ions and thicker filaments that aggregate into dense networks in the presence of multivalent ions.
Enhanced permselective separation of per-fluorooctanoic acid in graphene oxide membranes by a simple PEI modification
Authors: El Meragawi Sally , Akbari Abozar , Hernandez Sebastian , Mirshekarloo Meysam Sharifzadeh , Bhattacharyya Dibakar , Tanksale Akshat , Majumder Mainak
Published: November 2020

Strategic surface-modification techniques can tailor the effectiveness of graphene oxide-based loose nanofiltration membranes for the retention of emerging contaminants.
A stable metallic 3D porous BPC2 as a universal anode material for Li, Na, and K ion batteries with high performance
Authors: Younis Umer , Muhammad Imran , Qayyum Fizzah , Kawazoe Yoshiyuki , Sun Qiang
Published: November 2020

Materials composed of B, C, and P have been hotly pursued for batteries due to their low mass and high abundance.
Nanocomposite adhesive hydrogels: from design to application
Authors: Zhang Yuchen , Chen Qing , Dai Zhengwei , Dai Yu , Xia Fan , Zhang Xiaojin
Published: November 2020

Hydrogels may exhibit strong adhesion upon embedding nanoparticles into them forming strong/weak bonds (viathe multiple physical or chemical interactions).
High-capacitance polyurethane ionogels for low-voltage operated organic transistors and pressure sensors
Authors: Tabi Grace Dansoa , Kim Joo Sung , Nketia-Yawson Benjamin , Kim Do Hwan , Noh Young-Yong
Published: November 2020

A facile method to fabricate high-capacitance stretchable polyurethane ionogels is reported for organic transistor and pressure sensor applications, measuring remarkable mobility of ∼2 cm2V−1s−1and a high-pressure sensitivity of 0.12 kPa−1.
Ring fusion in tetrathienylethene cored perylene diimide tetramers affords acceptors with strong and broad absorption in the near-UV to visible region
Authors: He Qiao , Eisner Flurin D. , Pearce Drew , Hodsden Thomas , Rezasoltani Elham , Medranda Daniel , Fei Zhuping , Nelson Jenny , Heeney Martin
Published: November 2020

Two PDI tetramers with a central tetrathienylethene core were investigated as non-fullerene acceptors in organic photovoltaics and the dramatic differences in their optical absorption spectra were rationalised on the basis of DFT calculations.
High efficiency and long lifetime orange-red thermally activated delayed fluorescent organic light emitting diodes by donor and acceptor engineering
Authors: Kothavale Shantaram , Chung Won Jae , Lee Jun Yeob
Published: November 2020

Molecular design approach for the simultaneous achievement of high efficiency and long lifetime in the long wavelength region.
Tidally perturbed pulsations in the pre-main sequence δ Scuti binary RS Cha
Authors: Steindl T. , Zwintz K. , Bowman D. M.
Published: November 2020

Context. Stellar components in binaries are subject to tidal forces which influence asteroseismic properties. Tidally pertubed pulsations have been reported for different objects but none of these are in their pre-main sequence phase of evolution. This makes RS Cha, consisting of two δ Scuti stars and with pulsational characteristics influenced by tidal effects, the first such object observed.

Aims. We aim to investigate the pulsational properties of the eclipsing binary RS Cha in terms of the theory of tidally perturbed pulsations.

Methods. Based on photometric time series obtained from the TESS satellite, we performed binary modelling using PHOEBE to interpret the binary light curve and to allow the investigation of the pulsations of both components in RS Cha. We modelled the detrended light curve with the superposition of linear modes. The frequencies were then interpreted as self excited modes perturbed by tidal forces.

Results. We find evidence for tidally perturbed modes, which enables the identification of pulsation modes. RS Cha mainly exhibits dipole modes, while one prominent l = 2 or l = 3 mode is also inferred. The latter verifies previous results from spectroscopic time series.

Conclusion. This work shows that RS Cha is an ideal candidate to test the theory of tidally perturbed pulsations within the framework of asteroseismic modelling. The identification of multiple pulsation modes using this theory is unprecedented and will be a keystone in the future of pre-main sequence asteroseismology. However, amplitude modulation caused by the changing light ratio during the orbital phase in an eclipsing binary also plays a significant role, which can complicate mode identification.
Polarisation properties of methanol masers
Authors: Dall’Olio D. , Vlemmings W. H. T. , Lankhaar B. , Surcis G.
Published: November 2020

Context. Astronomical masers have been effective tools in the study of magnetic fields for years. Observations of the linear and circular polarisation of different maser species allow for the determination of magnetic field properties, such as morphology and strength. In particular, methanol can be used to probe different parts of protostars, such as accretion discs and outflows, since it produces one of the strongest and the most commonly observed masers in massive star-forming regions.

Aims. We investigate the polarisation properties of selected methanol maser transitions in light of newly calculated methanol Landé g-factors and in consideration of hyperfine components. We compare our results with previous observations and evaluate the effect of preferred hyperfine pumping and non-Zeeman effects.

Methods. We ran simulations using the radiative transfer code, CHAMP, for different magnetic field values, hyperfine components, and pumping efficiencies.

Results. We find a dependence between the linear polarisation fraction and the magnetic field strength as well as the hyperfine transitions. The circular polarisation fraction also shows a dependence on the hyperfine transitions. Preferred hyperfine pumping can explain some high levels of linear and circular polarisation and some of the peculiar features seen in the S-shape of observed V-profiles. By comparing a number of methanol maser observations taken from the literature with our simulations, we find that the observed methanol masers are not significantly affected by non-Zeeman effects related to the competition between stimulated emission rates and Zeeman rates, such as the rotation of the symmetry axis. We also consider the relevance of other non-Zeeman effects that are likely to be at work for modest saturation levels, such as the effect of magnetic field changes along the maser path and anisotropic resonant scattering.

Conclusions. Our models show that for methanol maser emission, both the linear and circular polarisation percentages depend on which hyperfine transition is masing and the degree to which it is being pumped. Since non-Zeeman effects become more relevant at high values of brightness temperatures, it is important to obtain good estimates of these quantities and the maser beaming angles. Better constraints on the brightness temperature will help improve our understanding of the extent to which non-Zeeman effects contribute to the observed polarisation percentages. In order to detect separate hyperfine components, an intrinsic thermal line width that is significantly smaller than the hyperfine separation is required.
The multiphase and magnetized neutral hydrogen seen by LOFAR
Authors: Bracco A. , Jelić V. , Marchal A. , Turić L. , Erceg A. , Miville-Deschênes M.-A. , Bellomi E.
Published: November 2020

Faraday tomography of polarimetric observations at low frequency in the radio is a unique tool for studying the structure of the magneto-ionic diffuse interstellar medium (ISM) based on Faraday depth. LOFAR data below 200 MHz have revealed a plethora of features in polarization, whose origin remains unknown. Previous studies have highlighted the remarkable association of such features with tracers of the magnetized-neutral ISM, such as interstellar dust and atomic hydrogen (HI). However, the physical conditions responsible for the correlation between magneto-ionic and neutral media have not been clarified yet. In this Letter we further investigate the correlation between LOFAR data and the HI spectroscopic observations at 21 cm from the Effelsberg-Bonn HI Survey (EBHIS). We focus on the multiphase properties of the HI gas. We present the first statistical study on the morphological correlation between LOFAR tomographic data and the cold (CNM), lukewarm (LNM), and warm (WNM) neutral medium HI phases. We use the Regularized Optimization for Hyper-Spectral Analysis approach to decompose the HI phases based on a Gaussian decomposition of the HI spectra. We study four fields of view – Fields 3C196, A, B, and C – and find, in at least the first two, a significant correlation between the LOFAR and EBHIS data using the histograms of oriented gradients (HOG) feature. The absence of a correlation in Fields B and C is caused by a low signal-to-noise ratio in polarization. The observed HOG correlation in Fields 3C196 and A is associated with all HI phases and it is surprisingly dominant in the CNM and LNM phases. We discuss possible mechanisms that would explain the correlation between CNM, LNM, and WNM with polarized emission at Faraday depths up to 10 rad m−2. Our results show how the complex structure of the ionic medium seen by the LOFAR tomographic data is tightly related to phase transition in the diffuse and magnetized neutral ISM traced by HI spectroscopic data.