bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Existing Steep Sloped Roof Assemblies for Changes to Thermal, Moisture, and Ventilation Performance: A New Joint E06/D08 Standard in Action
Authors: Wagner Carly May , Cyphers Rex A.
Published: May 2022

ASTM Draft, Standard Guide for Evaluation of Existing Steep Sloped Roof Assemblies for Changes to Thermal, Moisture, and Ventilation Performance, is currently being developed through a joint effort between ASTM E06 and ASTM D08. The draft standard is intended to provide guidance for assessing existing steep sloped roof assemblies and attic spaces prior to altering the insulation, vapor control layers, or ventilation aspects of the assemblies. With revisions to the energy codes now requiring insulation and continuous air barriers within the building envelope, the thermal- and vapor-resistant properties of existing steep sloped roof and attic assemblies are often altered without proper evaluation of the performance of the entire enclosure. The assemblies of existing buildings must be evaluated prior to such alterations to help ensure that the addition of insulation or vapor-resistant materials or the alteration to natural ventilation provisions does not cause moisture-related issues over the life of the building. This paper discusses the development of the draft standard and the strategy for formal balloting and collecting feedback between two ASTM committees. The paper also outlines the application of the standard by providing an overview of two case studies in which the procedures within the standard were executed successfully. One case study describes the field study and hygrothermal analysis needed to address condensation issues at an international airport terminal. A second case study describes the field study and review of condensation at the underside of a metal roof deck of an art museum.
Identification of a Developmental Switch in Information Transfer between Whisker S1 and S2 Cortex in Mice
Authors: Cai Linbi , Yang Jenq-Wei , Wang Chia-Fang , Chou Shen-Ju , Luhmann Heiko J. , Karayannis Theofanis
Published: May 2022

The whiskers of rodents are a key sensory organ that provides critical tactile information for animal navigation and object exploration throughout life. Previous work has explored the developmental sensory-driven activation of the primary sensory cortex processing whisker information (wS1), also called barrel cortex. This body of work has shown that the barrel cortex is already activated by sensory stimuli during the first postnatal week. However, it is currently unknown when over the course of development these stimuli begin being processed by higher-order cortical areas, such as secondary whisker somatosensory area (wS2). Here we investigate the developmental engagement of wS2 by whisker stimuli and the emergence of corticocortical communication from wS1 to wS2. Usingin vivowide-field imaging and multielectrode recordings in control and conditional KO mice of either sex with thalamocortical innervation defects, we find that wS1 and wS2 are able to process bottom-up information coming from the thalamus from birth. We also identify that it is only at the end of the first postnatal week that wS1 begins to provide functional excitation into wS2, switching to more inhibitory actions after the second postnatal week. Therefore, we have uncovered a developmental window when information transfer between wS1 and wS2 reaches mature function.

SIGNIFICANCE STATEMENTAt the end of the first postnatal week, the primary whisker somatosensory area starts providing excitatory input to the secondary whisker somatosensory area 2. This excitatory drive weakens during the second postnatal week and switches to inhibition in the adult.
The People’s Centenary? Public History, Remembering and Forgetting in Britain’s First World War Centenary
Authors: Noakes Lucy , Wallis James
Published: May 2022

Between 2014 and 2019, Great Britain and Northern Ireland undertook the largest public history project ever seen there. To mark the centenary of the First World War (1914–18) thousands of public arts projects, community histories, and acts of commemoration and remembrance took place across the country. This article explores a range of public arts projects, commemorative events, and community heritage projects to see what these widespread and diverse public histories can tell us about the cultural memory of the First World War in early twenty-first century Britain.
Novel Palliative Chemotherapy for Cholangiocarcinoma
Authors: Jung Jung Won , Woo Sang Myung
Published: May 2022

The term cholangiocarcinoma (CC) refers to all tumors arising from bile duct epithelium. CCs are characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. This leads to a paucity of data from which to define the natural history and optimal treatment regimens. Currently, surgical resection remains the only potentially curative treatment, but many patients develop recurrence. In addition, a limited number of patients can be candidates for curative resection at diagnosis. Therefore, chemotherapy is inevitable choice for the treatment of advanced CC. Gemcitabine plus cisplatin (GP) is considered a standard option for advanced biliary cancer. A randomized phase III trial (ABC-02 trial) showed the superiority of gemcitabine plus cisplatin over gemcitabine alone. Treatment with nab-paclitaxel plus gemcitabine-cisplatin prolonged median progression-free survival and overall survival vs. those reported for historical controls treated with gemcitabine-cisplatin alone in a phase II study of 60 patients with locally advanced unresectable or metastatic biliary tract cancer. Recent data of the ABC-06 trial has provided slight evidence for the use of second-line chemotherapy after progression on cisplatin plus gemcitabine combination. Other active regimens, that could be considered in patients who include have disease progression while receiving GP and who retain an adequate performance status, includes capecitabine plus cisplatin, liposomal irinotecan plus leucovorin-modulated fluorouracil and a fluoropyrimidine alone. We herein review recent published data regarding the use of palliative chemotherapies in CC patients, with a particular focus on novel cytotoxic agents.
Role of Urokinase-Type Plasminogen Activator Receptor in the Regulation of Angiogenic Properties of Sca1+ Vasculogenic Progenitor Cells
Authors: Dergilev К. V. , Tsokolaeva Z. I. , Beloglazova I. B. , Vasilets Yu. D. , Traktuev D. O. , Kulbitsky N. B. , Parfenova E. V.
Published: May 2022

Neoangiogenesis is the key process determining myocardial regeneration after infarction. The urokinase-type plasminogen activator receptor (uPAR) is known to play an important role in the regulation of endothelial cell function and postnatal angiogenesis. However, uPAR its involvement in the regulation of the properties of vascular progenitor cells remains poorly studied.   Aim: to evaluate uPAR expression on the surface of resident cardiac vascular progenitor cells (rcVPCs) and its impact on angiogenic cell properties in vitro as well as postinfarction cardiac vascularization.   Materials and Methods. We used immunofluorescent analysis of cryosections of a murine myocardial infarction model to characterize vessels and rcVPCs, and evaluatedв the angiogenic properties potential of vasculogenic progenitor cells using the «tube assay» and induction ofinducing differentiation in a specialized medium.   Results. We have found that the majority of Sca-1+ rcVPCs express the urokinase receptor and endothelial cell markers on their surface and are capable of proliferation and integration into the newly formed vessels in the injured area, indicating their possible involvement in thecontribution to vascularization process after infarction. After acute ischemic injury, the accumulation of vasculogenic progenitor cells (8+2 and 27+7 cells per visual field, respectively; P = 0.032) and vascularization processes (85+11 and 166+25 capillaries per visual field, respectively; P = 0.033) were observed in myocardium of uPAR-/- animals, compared with wild-type animals. Our studies demonstrated that Sca-1+ rcVCPs derived from uPAR-/- murine hearts demonstrated a reduced ability to form capillary-like structures and endothelial differentiation compared with Sca-1+ rcVCPs from hearts of wild-type mice.   Conclusion. Thus, uPAR deficiency may lead to impaired vasculogenic properties of Sca-1+ rcVCPs, which is likely due to the loss of regulatory influence of specific ligands and the ability to interact with signaling mediators such as integrins. From the viewpoint of regenerative medicine, the modulation of uPAR activity can be considered as a potential targetpromising approach for targeted regulation of vasculogenic progenitor cells properties and postnatal angiogenesis.

Highlight

   The urokinase-type plasminogen activator receptor is involved in the regulation of the angiogenic properties of Sca1+ vasculogenic progenitor cells.
Does Acute Appendicitis in Pregnancy a Clinical Challenge in Surgery Practice? Our Experience
Authors: Bolukbasi Hakan , Yilmaz Serhan , Yildirim Engin Okan , Ocakoğlu Aziz
Published: May 2022

Objective. This study was designed to compare the diagnosis, treatment, and results of acute appendicitis in pregnant and non-pregnant women. Material and Methods. Women between the ages of 18 and 40 who were operated for acute appendicitis between 2015 and 2020 were included in the study. Results. There were 27 (3.8%) patients in Group Pregnant, and 679 (96.2%) patients in Group non-Pregnant. The mean WBC values in Group P and Group non-P was 16.53±2.91 and 13.99±4.31 (x103), and there was a significant difference between the groups.Mean pain symptom duration time was 3.40±1.90 in Group P and 1.91±1.34 day in Group non-P, while it was significantly longer in Group P . When the preoperative USG reports were evaluated, no significant difference was found between the groups.The diagnosis was made by MRI in 2 (7.4%) pregnant patients who non-visualized according to the USG report. In Group P, 10 patients were laparoscopic, 17 patients open; In group non-P, 153 patients laparoscopic and 526 patients were operated using open surgery technique. While the mean operation time did not differ significantly between the groups. Length of hospital stay was significantly higher in Group P with 3.48±4.26 days to 1.95±1.45 days. Conclusion. Diagnosis and treatment of acute appendicitis during pregnancy may be difficult, but with advanced radiological examinations and experienced surgeons, these difficulties can be easily overcome.
Large Sacrococcygeal Teratoma in Fetus and Newborn: Clinical Case and Review
Authors: Butylkina Jekaterina , Volochovič Jelena
Published: May 2022

We present a clinical case of fetal and neonatal large sacrococcygeal teratoma. Sacrococcygeal teratoma mostly found in neonates, infant, and children below 4 years old and is more common in girls than boys. Antenatal fetus ultrasound is the main diagnostic method.  Antenatal diagnosis is very important making pregnancy care plan, time and method of delivery also to prevent fetal and neonatal death. Complete excision of the sacrococcygeal teratoma, including the coccyx, remains the mainstay of treatment. Patient's birth mother gives consent for information about the patient (photograph and article) to appear in a journal article.
Modeling and analysis of SIR epidemic dynamics in immunization and cross-infection environments: Insights from a stochastic model
Authors: Chang Zhengbo , Meng Xinzhu , Hayat Tasawar , Hobiny Aatef
Published: May 2022

We propose a stochastic SIR model with two different diseases cross-infection and immunization. The model incorporates the effects of stochasticity, cross-infection rate and immunization. By using stochastic analysis and Khasminski ergodicity theory, the existence and boundedness of the global positive solution about the epidemic model are firstly proved. Subsequently, we theoretically carry out the sufficient conditions of stochastic extinction and persistence of the diseases. Thirdly, the existence of ergodic stationary distribution is proved. The results reveal that white noise can affect the dynamics of the system significantly. Finally, the numerical simulation is made and consistent with the theoretical results.
Seizing Securities in Criminal Proceedings of the Russian Federation: Theory and Practice
Authors: Sokolova Marina , Fatyanov Alexey , Makeev Alexey , Blinova Elena , Gorlova Yulia , Alimamedov Elmir
Published: May 2022

The article discusses topical issues related to the difficulties encountered by the investigator when seizing securities. The authors, on the basis of the studied criminal procedural and civil legislation, proposed to amend the Code of Criminal Procedure of the Russian Federation, solving contradictions in theory and practice. Based on the results of studying the theoretical and practical aspects of the investigator’s activities in imposing seizure of securities, a number of issues were highlighted, which were studied in detail. In addition, proposals were made to improve the current criminal procedural legislation, which will allow the investigator to optimize the activities on the application of this measure in the future in procedural coercion, both in general and in relation to certain types of securities.Keywords: Bonafide Acquirer; Criminal Proceedings; Interrogator; Seizure of Securities Penyitaan Surat Berharga dalam Proses Pidana Federasi Rusia: Teori dan PraktikAbstrakArtikel ini membahas tentang kesulitan-kesulitan yang dihadapi penyidik dalam penyitaan surat berharga. Para penulis, berdasarkan undang-undang acara pidana dan perdata yang dipelajari, mengusulkan untuk mengubah Kode Acara Pidana Federasi Rusia, memecahkan kontradiksi dalam teori dan praktik. Berdasarkan hasil kajian aspek teoretis dan praktis dari kegiatan penyidik dalam melakukan penyitaan surat berharga, beberapa hal menjadi sorotan yang dikaji secara rinci. Selain itu, diusulkan untuk memperbaiki undang-undang acara pidana saat ini, yang memungkinkan penyidik untuk mengoptimalkan kegiatan penerapan tindakan ini di masa depan dalam paksaan prosedural, baik secara umum maupun dalam kaitannya dengan jenis surat berharga tertentu.Kata kunci: Pengakuisisi Bonafide; Proses Pidana; Interogator; Penyitaan Surat BerhargaКонфискация ценных бумаг в уголовном судопроизводстве Российской Федерации: Теория и практика АннотацияВ данной статье рассматриваются трудности, с которыми сталкиваются следователи при конфискации ценных бумаг. Авторы на основе изученного уголовно-процессуального и гражданского законодательства предложили внести изменения в Уголовно-процессуальный кодекс Российской Федерации, разрешающие противоречия в теории и практике. По результатам изучения теоретических и практических аспектов деятельности следователя при конфискации ценных бумаг выделен ряд вопросов, которые подробно изучены. Кроме того, предлагается внести изменения в действующий уголовно-процессуальный закон, которые позволили бы следователям оптимизировать их дальнейшее осуществление данного деяния в условиях процессуального принуждения как в целом, так и в отношении отдельных видов ценных бумаг.Ключевые Слова: Добросовестный Покупатель; Уголовное Судопроизводство; Дознаватель; Конфискация Ценных Бумаг
Halal Certification in Government and Non-Governmental Organizations: A Comparative Analysis of Indonesia, Malaysia, and Thailand
Authors: Yakub Aminudin , Zein Fitriyani
Published: May 2022

The enactment of Law Number 33 of 2014 concerning Halal Product Assurance (JPH) changed the implementation of Halal Certification in Indonesia where halal certification which had been carried out by MUI for 30 years (since 1989) changed to the Halal Product Assurance Organizing Agency (BPJPH) of the Ministry of Religion of the Republic of Indonesia. With this provision, a new era in the administration of Halal Product Guarantee by the government begins. This research uses qualitative research with juridical-normative and comparative approach. The author makes a comparison with Thailand and Malaysia. The results of the study state that the implementation of halal certification in Malaysia is carried out entirely by a state institution called JAKIM, while in Thailand it is carried out by non-governmental organizations (NGOs).Keywords: Halal Product Certification; Non-Governmental Organizations (NGOs); Ratio Sertifikasi Halal Melalui Pemerintah dan Organisasi Non-Pemerintah: Analisis Perbandingan Indonesia, Malaysia, dan Thailand Abstrak:Lahirnya Undang-undang Nomor 33 Tahun 2014 tentang Jaminan Produk Halal (JPH) mengubah pelaksanaan Sertifikasi Halal di Indonesia dimana sertifikasi halal yang telah dijalankan MUI selama 30 tahun (sejak 1989) berubah ke Badan Penyelenggara Jaminan Produk Halal (BPJPH) Kementerian Agama RI. Dengan ketentuan ini maka dimulai era baru penyelenggaraan Jaminan Produk Halal oleh pemerintah. Penelitian ini menggunakan penelitian kualitatif dengan pendekatan yuridis-normative dan perbandingan. Penulis melakukan perbandingan dengan negara Thailand dan Malaysia. Hasil penelitian menyatakan bahwa pelaksanaan sertifikasi halal di Malaysia dilakukan sepenuhnya oleh lembaga negara yang bernama JAKIM, sedangkan di Thailand dilakukan oleh lembaga non pemerintah (NGO).Kata Kunci: Sertifikasi Produk Halal; Organisisasi Non Pemerintah (NGO); Perbandingan Халяльная сертификация в государственных и негосударственных организациях: сравнительный анализ Индонезии, Малайзии и Таиланда Аннотация:Принятие Закона № 33 от 2014 г. о Гарантии на халяльный продукт (JPH) изменило внедрение халяльной сертификации в Индонезии, где халяльная сертификация, которая проводилась MUI (Советом Индонезийских Богослов) в течение 30 лет (с 1989 г.), была преобразована в Организационный орган по обеспечению халяльной продукции (BPJPH) Министерства по делам религии Республики Индонезии. С этим положением начинается новая эра в управлении гарантией на халяльный продукт со стороны правительства. В данном исследовании используются качественные исследования с юридически-нормативным и сравнительным подходами. Автор проводит сравнение с Таиландом и Малайзией. Результаты исследования показывают, что внедрение халяльной сертификации в Малайзии полностью осуществляется государственным учреждением под названием JAKIM, а в Таиланде - неправительственными организациями (NGO).Ключевые слова: Сертификация халяльной продукции; Неправительственные организации (NGOs); Соотношение
Inequities in Pain Assessment and Care of Hospitalized Children With Limited English Proficiency
Authors: Payson Alison , Pulido Anamaria , San Martin Stephanie , Garlesky Cindy , Garcia Erileen , Reyes Clara , Reyes Mario , Leyenaar JoAnna
Published: May 2022

OBJECTIVES

To examine inequities in pain assessment and management of hospitalized children with limited English proficiency (LEP) as assessed by (1) self-reported pain prevalence and intensity, and (2) nurse-documented pain assessments and analgesia.

METHODS

A cross-sectional survey of hospitalized children and parent proxies examined preferred language and pain prevalence, intensity, and etiology; subsequent electronic medical record chart review examined demographics, nurse-documented pain scores, and analgesia prescribed for children aged ≤21 years at a tertiary care children’s hospital. The primary outcome was a difference of ≥3 points between self-reported and nurse-documented worst pain scores. Descriptive statistics, Fisher’s exact tests, and multivariable logistic regression were used to identify differences in outcomes between children with and without LEP.

RESULTS

A total of 155 patients (50% children and 50% parental proxies) were interviewed (96% response rate). Of those, 60% (n = 93) reported pain in the previous 24 hours, most frequently because of acute illnesses. Of patients reporting pain, 65% (n = 60) reported a worst pain score of ≥3 points higher than nurse-documented scores; this discrepancy affected more patients with LEP (82%, n = 27) than English-proficient patients (55%, n = 33) (P = .01) with an adjusted odds ratio of 3.2 (95% confidence interval: 1.13–10.31). Patients with LEP were also less likely than English-proficient patients to receive medications at the time of their worst pain (60% vs 82%, P = .03), particularly opioid analgesia (9% vs 22%, P = .04).

CONCLUSIONS

Children with LEP were more likely to self-report pain scores that exceeded nurse-documented scores and received less medications, particularly opiates. This population may be particularly vulnerable to underassessment and inadequate management of pain.
Interventions to Promote Physical Activity and Healthy Digital Media Use in Children and Adolescents: A Systematic Review
Authors: Oh Christina , Carducci Bianca , Vaivada Tyler , Bhutta Zulfiqar A.
Published: May 2022

OBJECTIVES

To identify effective interventions that promote healthy screen time use and reduce sedentary behavior in school-aged children and adolescents (SACA) in all settings, over the last 20 years.

METHODS

Searches were conducted from 2000 until March 2021 using PubMed, Embase, Medline, PsycINFO, Ovid SP, The Cochrane Library, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, and the WHO regional databases, including Google Scholar and reference lists of relevant articles and reviews. Randomized-controlled trials and quasi-experimental studies assessing interventions to reduce sedentary behaviors and screen time in healthy SACA (aged 5-19.9 years) globally. Data were extracted by 2 reviewers and where possible, pooled with a random-effects model.

RESULTS

The review included 51 studies, of which 23 were included in meta-analyses with 16 418 children and adolescents. Nondigital randomized-controlled trials reported a small, but significant reduction of TV-specific screen time (minutes per day) (mean difference, −12.46; 95% confidence interval, −20.82 to −4.10; moderate quality of evidence) and sedentary behavior (minutes per day) (mean difference, −3.86; 95% confidence interval, −6.30 to −1.41; participants = 8920; studies = 8; P = .002; moderate quality of evidence) as compared with control groups. For quasi-experimental studies, nondigital interventions may make little or no difference on screen time (minutes per day) or sedentary behavior (minutes per day), given the high uncertainty of evidence. Most studies were conducted in a high-income country. Generalizability of results to low- and middle- income countries remain limited.

CONCLUSIONS

Public health policies and programs will be necessary to reduce excessive sedentary behavior and screen time, especially in the post-coronavirus disease 2019 reality.
INTERACTION OF INVESTIGATIVE AND OPERATIONAL SUBDIVISIONS DURING THE PRE-TRIAL INVESTIGATION
Authors: Pavlichenko Ye. V. , Pryvydentsev O. H.
Published: May 2022

The article clarifies the concept, essence and scientific basis of the investigator’s interaction with operational units; the role of theoretical provisions of interaction of the investigator with operative divisions is defined; the basis of interaction of the investigator with operative divisions is analyzed; modern levels, directions, forms and types of interaction of the investigator with operative divisions are considered; procedural and organizational-tactical aspects of the investigator’s interaction with operational units are revealed; the practical experience of organization and implementation of interaction of the investigator with operative divisions in criminal proceedings is generalized. It is determined that interaction of investigator and operational units in criminal proceedings should be defined as based on laws and regulations, as well as unanimity and agreement of tasks, which provides for effective application of legal measures, forces, forms, methods and tools aimed at effective investigation. The article forms theoretical conclusions, substantiates and highlights the main provisions and statements on improvement of practical principles associated with the interaction of the investigator with operational units during the criminal proceedings. On the basis of analytical researches of normative-legal maintenance of interaction of the investigator with operative divisions the conclusion on expediency of improvement of a normative field for the purpose of proper and timely execution of instructions of the investigator and the prosecutor by operative divisions is made. It is proved that during the execution of the instructions of the investigator, the prosecutor, the employee of the operational unit uses the powers of the investigator. Officers of operational units do not have the right to carry out procedural actions in criminal proceedings on their own initiative or to apply to the investigating judge or prosecutor. Only purposeful and systematic work of the investigator and the operative unit during the implementation of the sections will allow to use the capabilities of both subjects in the process of verification and collection of evidence by covert means effectively. In order to improve the interaction between the investigator and the operative unit at the legislative level, it is recommended to consolidate the right of the operative unit to initiate search and other procedural actions, to improve the procedure of joint investigative actions by the investigator and the operative unit.
LEGAL GUARANTEES OF FREEDOM OF CONSCIENCE AND RELIGION IN UKRAINE
Authors: Kravtsova M. O. , Datsiuk T. K. , Filipenko O. I.
Published: May 2022

The article identifies the main Ukrainian and international legal acts, which enshrine legal guarantees of freedom of conscience and religion. In particular, these rights are guaranteed by the European Convention on Human Rights, the Universal Declaration of Human Rights and Freedoms, the UN Charter, the International Covenant on Civil and Political Rights, the International Covenant on Economic, Social and Cultural Rights and a number of other acts. The legal consolidation of the rights of freedom, conscience and religion in the Constitution of Ukraine and the Law of Ukraine "On Freedom of Conscience and Religious Associations" is considered, the bodies responsible for normative-legal and legislative regulation of legal provision of freedom of conscience and freedom of religion in Ukraine are determined. It was found that the mechanism of protection of freedom of conscience and freedom of religion is a system of effective legal means of implementation, protection and defense of freedom of conscience and freedom of religion in general and its individual elements (opportunities) enshrined in the laws of a particular state. The assessment of normative legal acts showed that the issues of uncertainty in the conceptual apparatus used in the regulation of the religious sphere remain unresolved; uncertainty in the subjects of religious relations, their rights and responsibilities; unequal legal status of religious groups and religious organizations; the degree of state intervention in state-church relations. The concepts and elements of the mechanism of legal provision of freedom of conscience and freedom of religion of the person in Ukraine are defined.The criteria for classification of legal remedies for freedom of conscience and freedom of religion, which include national remedies and public institutions, are analyzed. It is concluded that the state policy in the field of protection of freedom of conscience should be aimed at finding an effective organization of the system of public administration and control. To this end, it is necessary to specify and clearly delineate the powers of public authorities of Ukraine and public authorities, officials and specialists of various bodies of public administration, control and supervision in the field of protection of freedom of conscience.
COMBATING POLITICAL CORRUPTION ON POLITICAL PARTY FINANCING: PROSPECTS FOR IMPLEMENTATION OF EU LEGISLATION
Authors: Maksimentseva N. O.
Published: May 2022

The article provides an analysis of the concept of "political corruption" under the laws of Ukraine and proves the lack of a clear definition and features of this concept. Instead, the author highlights the main features of political corruption, its differences from other types of corruption. In addition, the peculiarities of regulating the concept of "political corruption" in the Anti-Corruption Strategy 2020-2024 are analyzed. The article pays special attention to the types of political corruption, namely the financing of political parties and the experience of the European Union in addressing issues of transparency, control, prevention and combating illegal activities. Attention is paid to sources of financing, selection of their types and features of receipt of funds by certain types. The concept of "gifts" and issues related to this type of funding, transparency and legitimacy of gifts and such activities within the requirements of applicable law, setting limits on the amount of such income and the procedure for reporting and declaring the income of parties. A system of control over the transparency of the receipt of funds has been established: 1) the obligation of parties to report the fact and source of receipt; 2) provide information on legal and natural persons-donors; 3) the right of a specially authorized body of the EU to verify the revenues and contributions of political parties is defined. The procedure for financing political parties at the expense of state funds and the conditions for their provision, features of reporting and control over the expenditure of funds, areas of funding, restrictions and requirements for the receipt of funds, the procedure and requirements for declaring certain financial sources. It also mentions the rights and opportunities for measures taken by the bodies that control the financing of political parties from the budget of the European Union.
FEATURES OF THE IMPLEMENTATION OF THE PRINCIPLE OF JUSTICE IN THE EXECUTION OF COURT DECISIONS
Authors: Shelever N. V.
Published: May 2022

A fair court decision is the goal of justice. The meaning of justice is achieved only when the court decision is executed. Otherwise, the court decision remains only a sheet of paper. Execution of court decisions is the final stage of the court process, which has as its purpose the implementation of the court decision. That is, in the execution of a court decision, the principle of justice is implemented in practice. The state executive service is responsible for enforcing court decisions. In accordance with the Constitution of Ukraine, the state must ensure the execution of a court decision. In addition to the adoption of an act of justice, courts must exercise appropriate judicial control over its execution. The author also draws attention to the fact that in practice there is often a “formal” execution, as enforcement proceedings are closed for one reason or another, and there is no actual execution of the court decision. The European Court of Human Rights singles out another problematic issue in Ukraine – the long-term non-enforcement of national court decisions. After analyzing the work of the state executive service, the author came to the conclusion that the situation is quite complicated. Compared to European countries, the performance rate is low. Due to the legal nihilism of the citizens of Ukraine, it is quite difficult to enforce court decisions in our country. Since the execution of court decisions is a component of the right to a fair trial, the author summarizes the experience, proposals of state executors and analyzes the relevant problems. Among them there are such as low wages of employees of the state executive service, the lack of proper security for state executors in the execution of court decisions, the need to increase the staff in the state executive service. Proposes to expand the rights of state executors and take active measures to combat corruption in the courts. Inadequate cooperation of banks, police and other bodies with the state executive service is also a big problem in practice, which significantly complicates the work of state executors and slows down the execution of court decisions. Therefore, the author summarizes the proposals of state performers and sets them out in the proposed article. In connection with Ukraine’s desire to become a full member of the European Union, the need to study the experience of leading member states in order to implement it in domestic legislation is emphasized.
ADMINISTRATIVE AND LEGAL REGULATION OF PUBLIC ADMINISTRATION IN THE FIELD OF PHYSICAL CULTURE
Authors: Morhunov O. A.
Published: May 2022

The purpose of the article is to study the administrative and legal regulation of public administration in the field of physical culture. The article examines the administrative and legal regulation of public administration in the field of physical culture. It is determined that the administrative and legal regulation of public administration of physical culture should be defined as a set of administrative and legal norms and other administrative and legal means by which to consolidate, streamline, protect relations with the participation of subjects of power in these areas in the interests of man, society and the state through the mechanism of administrative and legal regulation. The leading place in the legal regulation of the spheres of physical culture and sports belongs to the norms of administrative law, which form the basis of public administration of these spheres, determining the status of public administration, principles, bases, forms and methods of their official activity, priorities and ways of forming state policy. physical culture and sports, means and procedures for its implementation, regulate control and supervision in these areas. Also, administrative and legal regulation takes place to regulate relations in the fields of physical culture and sports with the participation of subjects of power to protect the rights and freedoms of individuals and their groups, bring to administrative responsibility, prevent and combat corruption in these areas. Administrative and legal regulation of public administration of physical culture can be understood as a set of administrative and legal norms and other administrative and legal means that consolidate, streamline, protect relations with the participation of subjects of power in these areas in the interests of man, society and state through the mechanism administrative and legal regulation, which ensures the implementation of administrative and legal regulation in the legal behavior of participants in administrative relations on the basis of perception and subsequent reflection in socially significant activities in the forms of compliance and application of administrative norms.
Bem-estar psicológico, sintomas de depressão e forças do caráter em idosos da comunidade
Authors: Freitas Eduarda Rezende , Barbosa Altemir José Gonçalves
Published: May 2022

Em um mundo com um número crescente de idosos, envelhecer bem se torna cada vez mais importante, e as forças do caráter podem contribuir para que isso seja alcançado. A fim de analisar forças na velhice, associando-as com sintomas depressivos e bem-estar psicológico, 188 idosos responderam às versões reduzidas e em português dos instrumentos Values-in-Action Inventory of Strengths, Escala de Depressão Geriátrica e Philadelphia Geriatric Center Morale Scale. As forças Amor, Esperança, Curiosidade, Perdão e Vitalidade se associaram tanto a níveis mais elevados de bem-estar psicológico quanto a mais baixos de sintomas depressivos. Foram obtidas correlações significativas entre seis forças e sintomas depressivos – negativas fracas – e entre 11 delas e bem-estar psicológico – positivas fracas. Os resultados deste estudo ampliam, ainda que limitadamente, o conhecimento sobre forças de idosos, especialmente como elas se relacionam com dois construtos que influenciam a velhice. Ademais, fornecem uma base para o desenvolvimento de intervenções futuras.
Pensar Criticamente
Authors: Liebel Vinícius
Published: May 2022

ROLLEMBERG, Denise; CORDEIRO, Janaína (org.). Por uma Revisão Crítica – Ditadura e Sociedade no Brasil. Salvador: Sagga, 2021. 468 p.
Ensino secundário e as Classes Integrais do Colégio Estadual do Paraná
Authors: Junior Sergio Roberto Chaves
Published: May 2022

O texto apresenta questões relacionadas aos aspectos formativos das Classes Integrais do Colégio Estadual do Paraná (CEP), experiência de inovação pedagógica do ensino secundário desenvolvida entre 1960 e 1967 no modelar colégio situado em Curitiba-PR. Essa experiência, em conjunto com as iniciativas congêneres desenvolvidas em outras instituições de ensino brasileiras e que atenderam pela denominação de Classes Experimentais, constituíram parte das propostas de inovação pedagógica desenvolvidas a partir dos anos 1950 em território nacional. A análise das fontes possibilitou a identificação de um conjunto de ações pedagógicas desenvolvidas visando à formação integral dos estudantes participantes das turmas selecionadas para aquela inovação educacional, tendo em vista as transformações sociais do contexto.
Visões sobre o processo de escrita
Authors: Abed Carolina Zuppo
Published: May 2022

Este artigo propõe analisar os processos criativos por um viés interdisciplinar, investigando sobretudo o papel do caos na criação (de modo geral) e na escrita (especificamente). A hipótese de trabalho desenvolvida é a de que os atos de criação resultam de um trânsito contínuo entre a ordem e a desordem – e que, para criar, é preciso manter-se em uma zona indeterminada entre esses dois polos. O ponto de partida para tal proposição está nas reflexões de Deleuze (2006) e de Agamben (2017) sobre os atos criativos. Teorias das artes visuais (OSTROWER, 2014) e pensamentos de filosofias milenares orientais (Tao Te Ching e Rig Veda) também contribuíram para pensar a questão. Espera-se, com as reflexões aqui propostas, situar o debate acerca dos mecanismos de criação no paradigma filosófico-científico da complexidade, tal como defendido por Morin (2000), e contribuir para uma maior compreensão dos processos criativos em escrita.
HRCT chest in patients suffering from COVID-19: Experience from a tertiary care centre in India during second wave of the pandemic
Authors: Firdose Syed Ruzina , Mattoo Priyanka , Malik Aadil Hussain , Viqar Arif
Published: May 2022

Aim

The objective of the present study is to describe high-resolution CT (HRCT) chest manifestations of coronavirus disease 2019 (COVID-19) patients during second wave of the pandemic in a tertiary care hospital in New Delhi, India. We also aim to compare the findings on the HRCT chest during the second wave of COVID-19 with the data form earlier outbreaks and to look for any features specific to the second wave and thus indirectly to the delta variant of SARS-CoV-2. We also assessed the severity of the pulmonary involvement based on HRCT findings.

Methods

We analysed HRCT chest findings in 237 patients with COVID-19 admitted at our institute from 1st April 2021 to 31st May 2021. Covid-19 infection was confirmed by reverse transcription polymerase chain reaction (rt-PCR) or rapid antigen test (RAT) in all these patients.

Results

The mean age in our study group was 51.3 ± 12.1 years (range 19–79 years) comprising of 136 males (57.4%) and 101 females (42.6%). The majority of the patients showed bilateral (95.3%) and peripheral (42.6%) distribution of the disease. Ground glass opacities were the most common finding, seen in 214 (90.3%) patients, followed by interlobular septal thickening in 202 (85.8%) and crazy paving in 194 (81.3%) patients. Majority (36.7%) of these patients had a CT severity score above 20 indicating severe disease.

Conclusion

A typical pattern of peripheral subpleural often bilateral distribution of ground glass opacities on HRCT chest usually points to the possibility of COVID-19 pneumonia. The higher incidence of abnormalities on HRCT chest in patients with infection mainly from the delta variant of SARS-Cov-2 was mainly because of the more severe disease in the population. More research is needed to further evaluate the role of HRCT chest in the diagnosis of COVID-19 caused by different strains of the virus.
Systematic review and meta-analysis of probiotics in the treatment of allergic rhinitis
Authors: Yan Shuiping , Ai Si , Huang Lizhen , Qiu Caixia , Zhang Fangting , He Ningxin , Zhuang Xiangli , Zheng Jian
Published: May 2022

Background: The purpose of this meta-analysis is to systematically evaluate the efficacy of probiotics on allergic rhinitis (AR).
Methods: Collecting randomized controlled trials (RCTs) with probiotics as intervention measures for AR, two researchers independently screened the literature, extracted the data and evaluated the methodological quality of the included studies, and used RevMan 5.3 software for meta-analysis to observe the effects of probiotics on Rhinitis Quality of Life (RQLQ) scores, Rhinitis Total Symptom Scores (RTSS), blood eosinophil count, total and antigen-specific serum immunoglobulin E (IgE) levels by using the fixed- or the random-effects model to calculate the pooled risk for significant heterogeneity.
Results: A total of 2708 patients were included in 30 RCTs. Meta-analysis results showed that the RQLQ global scores (mean difference [MD] = −9.43; P < 0.00001), RQLQ nasal scores (MD = −1.52; P = 0.03), and RTSS nasal scores (MD = −1.96; P = 0.02) significantly improved in the probiotic group when compared with those in the placebo group. There was no significant difference in blood eosinophil count (MD = −0.09; P=0.82), RQLQ eye scores (MD = −1.45; P = 0.07), RTSS global scores (MD = −2.24; P = 0.26), RTSS eye scores (MD = −0.39; P = 0.31), total and antigen-specific serum IgE levels (MD = −0.04; P = 0.7 and MD = −0.08; P = 0.81) between the probiotic and the placebo group.
Conclusion: Compared with the placebo group, the quality of life and symptoms of patients with AR significantly improved in the probiotic group, thus providing a new potential method for the application of probiotics in AR. However, because of the limited evidence for the current study outcomes, the heterogeneity of research, and the differences in research results, more high-quality studies are needed to in the future.
Long-term outcome of omalizumab-assisted desensitisation to cow’s milk and eggs in patients refractory to conventional oral immunotherapy: real-life study
Authors: Ayats-Vidal Roser , Riera-Rubió Silvia , Valdesoiro-Navarrete Laura , García-González Miguel , Larramona-Carrera Helena , Asensio-De la Cruz Oscar , Bosque-García Montserrat
Published: May 2022

Background: Oral immunotherapy (OIT) is a promising approach to cow’s milk and egg allergies, but reactions are frequent and some patients cannot be desensitized.
Objective: To evaluate long-term OIT outcomes with omalizumab (OMZ) in paediatric patients with severe egg and/or milk allergies.
Methods: This retrospective real-life study analysed findings in children with Immunoglobulin E-mediated allergy to cow’s milk and/or hen eggs refractory to conventional OIT, who underwent OIT with OMZ in our department between 1 January 2010 and 31 December 2015.
Results: In all, 41 patients were included (median age: 7 years; interquartile range [IQR]: 5.5–9.5); 26/41 (63.4%) underwent OIT for milk, 8/41 (19.5%) for egg and 7/41 (17.1%) for both. The median time between initiation of OMZ and OIT was 27 weeks (IQR: 22–33). Forty (97.56%) patients reached the maintenance phase (200 mL of cow’s milk and 30 mL of raw egg or 1 cooked egg) in a median time of 27 weeks (IQR: 18–37). The median total time with OMZ was 117 weeks (IQR: 88–144). During the OMZ period, 2.44% (1/41) of patients presented anaphylaxis. After discontinuation of OMZ, 29.3% (12/41) presented anaphylaxis, 50% of them had a poor adherence to daily ingestion. One patient (2.44%) was diagnosed with eosinophilic esophagitis after 2 years of discontinuation of OMZ. Currently, after a median time of 9 years (IQR: 7–10) since the initiation of OMZ, 75.6% (31/41) are desensitized (27/31 without OMZ).
Conclusions: Omalizumab allows desensitisation of children with severe allergies to cow’s milk and/or egg without developing severe reactions while receiving this treatment. However, discontinuation of OMZ leads to severe allergic reactions, and hence must be monitored carefully.
Dedicator of cytokinesis protein 2 knockdown ameliorates LPS-induced acute lung injury by modulating Rac1/2 activity
Authors: Zhou Yan , Hu Wan
Published: May 2022

Dedicator of cytokinesis protein 2 (DOCK2) is a member of the cytoskeletal dynamics protein family, and is ubiquitously expressed in hematopoietic cells according to previous studies. This paper was intended to explore the underlying mechanism that DOCK2 might involve in the progression of acute lung injury (ALI). Following lipopolysaccharide (LPS) induction in the purchased A549 cells, the expression level of DOCK2 was determined and its knockdown was performed by transfection. Subsequently, the viability, inflammation, oxidative stress barrier, and apoptosis of transfected A549 cells were measured to observe the alterations. Inflammation-related and apoptosis-related proteins were measured by western blot analysis. Finally, 8-Chlorophenylthio-cyclic monophosphate (8-CPT), ras-related C3 botulinum toxin substrate (Rac) 1 agonist, was applied to treat cells for investigating the underlying mechanism regarding the role of DOCK2. According to the results, DOCK2 was upregulated in LPS-induced A549 cells. Following the knockdown of DOCK2, the release of inflammatory cytokines was alleviated, accompanied by attenuated oxidative stress, barrier injury, and apoptosis of LPS-induced A549 cells. Nonetheless, this trend was reversed by further treatment of 8-CPT. In summary, DOCK2 knockdown alleviates inflammation, oxidative stress, barrier injury, and apoptosis of LPS-induced A549 cells by associating with Rac1/Rac2. These findings highlighted the therapeutic potential of DOCK2 for the treatment of ALI.