bluuebunny/crossref_metadata_2025 huggingface dataset:
EDANet: Efficient Dynamic Alignment of Small Target Detection Algorithm
Authors: Zhu Gaofeng , Zhu Fenghua , Wang Zhixue , Yang Shengli , Li Zheng
Published: January 2025

Unmanned aerial vehicles (UAVs) integrated with computer vision technology have emerged as an effective method for information acquisition in various applications. However, due to the small proportion of target pixels and susceptibility to background interference in multi-angle UAV imaging, missed detections and false results frequently occur. To address this issue, a small target detection algorithm, EDANet, is proposed based on YOLOv8. First, the backbone network is replaced by EfficientNet, which can dynamically explore the network size and the image resolution using a scaling factor. Second, the EC2f feature extraction module is designed to achieve unique coding in different directions through parallel branches. The position information is effectively embedded in the channel attention to enhance the spatial representation ability of features. To mitigate the low utilization of small target pixels, we introduce the DTADH detection module, which facilitates feature fusion via a feature-sharing interactive network. Simultaneously, a task alignment predictor assigns classification and localization tasks. In this way, not only is feature utilization optimized, but also the number of parameters is reduced. Finally, leveraging logic and feature knowledge distillation, we employ binary probability mapping of soft labels and a soft label weighting strategy to enhance the algorithm’s learning capabilities in target classification and localization. Experimental validation on the UAV aerial dataset VisDrone2019 demonstrates that EDANet outperforms existing methods, reducing GFLOPs by 39.3% and improving Map by 4.6%.
Energy Management Strategy for Direct Current Microgrids with Consideration of Photovoltaic Power Tracking Optimization
Authors: Li Fudong , Shi Zonghao , Zhu Zhihao , Gan Yongjun
Published: January 2025

In response to the uncertainty of renewable energy output and the fluctuation of load, this paper proposes a hybrid energy storage management strategy based on the State of Charge (SOC) to smooth power fluctuations and thereby improve the power quality of photovoltaic energy storage DC microgrids. Firstly, a hybrid algorithm for power tracking control is formed by incorporating the Particle Swarm Optimization (PSO) algorithm into the variable step-size Incremental Conductance (INC) method, thereby optimizing the maximum power point tracking control system of the photovoltaic system. Then, a first-order filter is employed for the initial allocation of demand power. Taking the SOC of supercapacitors and energy storage batteries as a reference, a secondary power allocation energy management strategy based on rule-based control is proposed to ensure the service life and application safety of the hybrid energy storage system. Finally, simulation experiments are conducted in MATLAB/Simulink 23.2 (R2023b). The results indicate that the proposed energy management strategy can maintain the SOC of the hybrid energy storage system at a reasonable level and effectively smooth DC bus voltage fluctuations.
A Lifecycle Analysis of a Floating Power Plant Using Biomethane as a Drop-In Fuel for Cold Ironing of Vessels at Anchorage
Authors: Mallouppas George , Ktoris Angelos , Yfantis Elias Ar. , Petrakides Sotiris , Drousiotis Marios
Published: January 2025

The purpose of this research article is to perform a greenhouse gas (GHG) impact assessment using a lifecycle analysis of a cold-ironing solution for vessels at anchorage in a retrofitted barge and a marine genset combusting biomethane in dual fuel mode. A lifecycle methodology is developed based on the 4th International Maritime Organization (IMO) GHG study. Eleven impact scenarios are evaluated in terms of CO2 and harmful pollutants (SOx, CO, PM10, PM2.5, NMVOC, and NOx). Vessels operated by Petronav Ship Management Ltd are examined, specifically M/T Alexandria and M/T Astraia. The scenarios reveal CO2 reductions of up to 21% and CO increases of up to 60% due to the combustion of biomethane in dual fuel mode, alongside SOx reductions of up to 20% with increasing biomethane energy substitution. Particulates and NOx decrease due to the utilization of biomethane. This article presents a pragmatic solution for cold ironing for vessels at anchorage with proven lower GHG emissions with the exception of increased CO emissions, therefore the benefits outweigh the drawbacks.
Fracture Failure Model of Caragana korshinskii Kom. Branches Constructed Using ABAQUS/Explicit
Authors: Su Qiang , Zhang Jianchao , Liu Wenhang , Ma Xuejie , Yu Zhihong , Liu Zhixing
Published: January 2025

This study focuses on developing a finite element model for Caragana korshinskii Kom. branches and calibrating the necessary parameters. Using Caragana korshinskii Kom. branches in full bloom as the subject, we established a finite element model with ABAQUS and analyzed the relationship between the shear force and displacement. The Johnson–Cook model was employed to create a finite element shear model for Caragana korshinskii Kom. branches and to calibrate its parameters. Plackett–Burman and climbing tests were conducted to identify key parameters influencing the shear mechanical model of Caragana korshinskii Kom. branches, specifically the yield stress and strain. This included the strengthening index and fracture strain. Through central composite design experiments, the optimal parameters for the shear model of Caragana korshinskii Kom. branches were identified: a yield stress of 18.65 MPa, a strain strengthening index of 0.59, and a fracture strain of 0.54. The results indicated that the maximum error in the simulated shear force values for Caragana korshinskii Kom. branches of varying diameters was 9.68%. Additionally, the difference between the simulated and actual tensile force values was 1.7%. These findings indicate that the calibrated finite element model is accurate and effective in simulating the failure behavior of Caragana korshinskii Kom. branches, providing a valuable tool for optimizing cutting and harvesting processes.
Hybrid Modification of Wheat Bran Using Microbial Processing and Ultrasound: Enhancements in Bran Composition and Bread Quality
Authors: Sik Esra , Bekiroglu Hatice , Icyer Necattin Cihat , Ozulku Gorkem
Published: January 2025

This study investigates the effects of microbial bioprocessing (MB), ultrasound treatment (UT), and their combined application (hybrid method, HM) on the functional and nutritional enhancement of wheat bran (WB) and its impact on bread quality. MB was performed by using Saccharomyces cerevisiae with Levilactobacillus brevis LABE 32 (MB32) and Lactiplantibacillus plantarum LABE 29 (MB29). MB32 significantly increased soluble dietary fiber (SDF) and reduced phytic acid content by up to 25.7% when compared to the control. UT further decreased phytic acid content by 52.2% and enhanced phenolic compound release, contributing to improved antioxidant activity. The hybrid method (HM) demonstrated the strongest effect, reducing phytic acid content by 95% and enhancing antioxidant properties, including a 2.4-fold increase in bound antioxidant activity (bound-AA). Bread produced from modified WB showed improvements in specific volume (SV), texture, and nutritional composition. The HM-treated WB yielded bread with the highest SV, approximately 10% greater than the control, while MB29 produced significantly harder bread than other samples (p < 0.05). The HM-treated bread had the highest crust L* value and softest texture (p < 0.05). Nutritionally, only UT and HM treatments significantly increased the total dietary fiber (TDF) content, with the most pronounced increase observed in the HM treatment. Phytic acid degradation in the WB modified with MB32 and UT was in accordance with their breads, notably lowering phytic acid content. Additionally, MB32 and HM increased total phenolic content (TPC) and antioxidant activity, enhancing the bread’s overall nutritional quality. In conclusion, the hybrid application of MB and UT (HM) proved to be the most effective in improving the functional and nutritional properties of WB and the resulting bread, including increased dietary fiber content, reduced phytic acid levels, and enhanced antioxidant activity.
Seasonal Determination of Antibiotic-Resistant Microorganisms and Ciprofloxacin Residues in Pork and Chicken Meats Collected from Fresh Markets in Chiang Mai, Northern Thailand
Authors: Dokuta Sirikwan , Yadoung Sumed , Hongjaisee Sayamon , Khamnoi Phadungkiat , Manochomphu Sirinya , Chuttong Bajaree , Hongsibsong Surat
Published: January 2025

Antibiotic-resistant bacteria are usually found in food-producing animals worldwide. Ciprofloxacin, an antibiotic, can lead to antibiotic residues in food products, posing health risks to consumers and contributing to the development of antimicrobial resistance. Foodborne illnesses occur when adequate attention is not paid to food hygiene and safety, raising the potential for resistant bacteria to spread to humans through the food chain. This study aims to determine the presence of antibiotic-resistant organism contamination and ciprofloxacin residue in raw pork and chicken. Forty-three pork and 33 chicken meat samples were collected from fresh markets in Chiang Mai, Thailand. Antibiotic-resistant organisms were detected by microbial culture and identified by MALDITOF-MS. The antimicrobial sensitivity tests were used to confirm antibiotic resistance. The ciprofloxacin was detected by using an immunochromatographic-based test kit for screening. The results found Extended Spectrum β-lactamase (ESBL)-producing E. coli and K. pneumoniae were detected at 46.51% and 9.30% in pork and 69.70% and 6.06% in chicken meat samples, respectively. Moreover, ciprofloxacin residues were detected in nine samples (11.84%). Based on this study’s findings, the people who are involved in the food chain must be concerned about food safety and food hygiene.
Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies
Authors: Hyży Aleksandra , Rozenek Hanna , Gondek Ewa , Jaworski Mariusz
Published: January 2025

Background: Antioxidants are widely recognized for their potential health benefits, including their impact on cognitive function and gut microbiome modulation. Understanding these effects is essential for exploring their broader clinical applications. Objectives: This review aims to evaluate the effects of antioxidants on the gut microbiome and cognitive function, with a focus on findings from randomized controlled trials (RCTs). Methods: The studies involved human participants across a range of age groups, with interventions encompassing natural antioxidant sources, such as berries, as well as specific antioxidant vitamins. An extensive search across PubMed, SCOPUS, and Web of Science databases identified six relevant RCTs, each evaluated for potential bias. Results: These studies focused on a variety of antioxidant-rich products, including both naturally derived sources and supplemental forms. Antioxidants, including vitamins C, B2, and D, along with polyphenols such as xanthohumol, fermented papaya, peanuts, and berry extracts, demonstrate the potential to support cognitive function and promote gut health through mechanisms that modulate microbiome diversity and reduce inflammation. However, observed changes in microbiome diversity were modest and inconsistent across the studies. Conclusions: While preliminary evidence suggests that antioxidants may benefit gut health and cognitive function, the heterogeneity of existing studies limits their immediate clinical applicability. Additionally, more robust RCTs are needed to substantiate these findings and guide future interventions.
Genome-Wide Insights into Internalizing Symptoms in Admixed Latin American Children
Authors: Britto Gabriela de Sales Guerreiro , Moreira Alberto O. , Bispo Amaral Edson Henrique , Santos Daniel Evangelista , São Pedro Raquel B. , Barreto Thaís M. M. , Feitosa Caroline Alves , Neves dos Santos Darci , Tarazona-Santos Eduardo , Barreto Maurício Lima , Figueiredo Camila Alexandrina Viana de , Costa Ryan dos Santos , Godard Ana Lúcia Brunialti , Oliveira Pablo Rafael Silveira
Published: January 2025

Background/Objectives: Internalizing disorders, including depression and anxiety, are major contributors to the global burden of disease. While the genetic architecture of these disorders in adults has been extensively studied, their early-life genetic mechanisms remain underexplored, especially in non-European populations. This study investigated the genetic mechanisms underlying internalizing symptoms in a cohort of Latin American children. Methods: This study included 1244 Brazilian children whose legal guardians completed the Child Behavior Checklist (CBCL) questionnaire. Genotyping was performed using the Illumina HumanOmni 2.5-8v1 BeadChip. Results: The genome-wide association analysis revealed a significant association of rs7196970 (p = 4.5 × 10−8, OR = 0.61), in the ABCC1 gene, with internalizing symptoms. Functional annotation highlighted variants in epigenetically active regulatory regions, with multiple variants linked to differential expression of ABCC1 across several human tissues. Pathway enrichment analysis identified 42 significant pathways, with notable involvement in neurobiological processes such as glutamatergic, GABAergic, and dopaminergic synapses. Conclusions: This study identifies ABCC1 variants as novel genetic factors potentially associated with early-life internalizing symptoms. These results may contribute to future research on targeted interventions for childhood internalizing conditions.
Seedling Growth and Systemic Uptake of Liquid Vermicompost-Coated Seeds in Organic Pumpkin (Cucurbita sp.)
Authors: Pola Wissanee , Aiamla-or Sukanya
Published: January 2025

Liquid vermicompost (LVC) is one of the organic ingredients for improving plant growth. This study aims to investigate the impact of the application of LVC coating formulations in distinct ratios on seeding emergence, seedling growth parameters, and nitrogen content as well as the systemic uptake characteristics in seedlings. Coating formulations contained gum arabic (GA) mixed with 5–15% of LVC and were applied to pumpkin seeds and compared to non-coated seeds. All samples were stored under cold and ambient conditions for 3 months to evaluate the performance of the coating. Results showed no statistical distinctions in the percentage of seedling emergence. Nevertheless, the 5LVC-GA in the organic formulation significantly increased shoot length, seedling growth rate (SGR), seedling vigor index (SVI), and nitrogen content (%) in the coated seedlings. Additionally, the evaluation of seedling uptake was achieved using rhodamine B as a fluorescent tracer which was diluted in the organic formulation. This explored the transportation of the treatment within a seedling. Therefore, the application of an optimum concentration of 5LVC-GA treatment can improve seedling growth and nitrogen accumulation. This could be confirmed with fluorescence imaging of translocation to seedling organs. However, seed storability declines over three months, emphasizing the need for better coatings and packaging solutions.
Exploring the Role of Communication Asset Mapping (CAM) as a Strategy to Promote Hereditary Cancer Risk Assessment Information Within African American Communities
Authors: Lumpkins Crystal Y. , Kaphingst Kimberly A. , Miller Lynn R. , Cooper Evelyn , Smith Margaret , Belshe Katie , Lumpkins Garry , Peltzer Jill , Adsul Prajakta , Wray Ricardo
Published: January 2025

Objective: African Americans (AAs) carry the largest burden for almost every type of cancer in the US and are also more likely to die from cancer. Approximately 10% of cancers can be explained by a hereditary factor and detected earlier. Many AAs, however, have inequitable access to hereditary cancer risk assessment (HCRA) tools and information, further exacerbating disparities in cancer rates. Innovative communication strategies to promote community-based HCRA information have promise as a means encouraging optimal primary cancer screening among AAs. The current pilot study followed a participatory process where researchers engaged with a Community Advisory Board (CAB) to explore how Communication Asset Mapping (CAM) could assist lay health advisors with the dissemination of evidence-based HC/RA information within AA faith communities. Methods: The research team and CAB conducted exploratory community-engaged group discussions with residents (n = 21) guided by Communication Infrastructure Theory, and used a community-engaged mapping process to inform the development of a CAM dissemination strategy. Results: Through textual analysis, the following conclusions were reached: (1) optimal locations (e.g., community centers) within specified neighborhood networks should have representatives who are trusted ambassadors to assist with HCRA information dissemination; (2) trusted community member voices should fully represent the neighborhood network in the community-engagement mapping process; (3) well-known and frequented geographic locations should provide a true representation of participants’ neighborhoods to create a robust health information network concerning HCRA. Conclusions: Community residents appreciated the engagement process; however, they felt that its impact was limited due to the lack of community voices within their neighborhoods to identify important communication resources within the network for optimal HCRA information dissemination. CAM, therefore, is an important public health strategy for the identification of trusted networks and useful communication resources within these networks. The strategy was also helpful in pinpointing people who could be critical communicators of emerging health information akin to HCRA.
Patterns of Change in Athletic Identity After Anterior Cruciate Ligament Reconstruction
Authors: Brewer Britton W. , Shinnick Rachel , Cornelius Allen E. , Van Raalte Judy L. , Badiei Fahimeh
Published: January 2025

Changes in athletic identity have been documented after injury and other sport transitions in nomothetic investigations. Patterns of change in athletic identity after injury have not been examined systematically at the individual level. In the current study, secondary analyses were performed on two data sets (N = 43 and N = 80) in which athletic identity values were available for before and at least six months after anterior cruciate ligament (ACL) reconstruction. A stable pattern of athletic identity was most common (48–68% of participants), followed, respectively, by a decreasing pattern (19–45% of participants) and an increasing pattern (7–14% of participants) in both data sets, with a trend toward a decreasing pattern over time in the data set in which athletic identity values were available up to two years after surgery. Partial support was obtained for the claim that decreases in athletic identity after ACL surgery are related to postoperative perceptions of knee symptoms and function. The current intraindividual findings complement the results of nomothetic studies and suggest that although stability of athletic identity after sport injury seems to be the norm, changes in athletic identity are also common and should be considered in applied work with athletes who have sustained injuries.
Biomonitoring of Hydroxylated Polycyclic Aromatic Hydrocarbon Metabolites in Workers at a Waste-to-Energy Incinerator, Turin, Italy
Authors: Farina Elena , Iamiceli Anna Laura , Orengia Manuela , Gandini Martina , Crosetto Laura , Abate Vittorio , De Filippis Stefania Paola , De Luca Silvia , Iacovella Nicola , De Felip Elena , Bena Antonella
Published: January 2025

This paper presents the results of the human biomonitoring of ten urinary OH-PAHs (hydroxylated polycyclic aromatic hydrocarbon) in a cohort of workers at an incinerator in Turin, Italy. Long-term exposure was assessed through repeated measurements at three time points: before the startup (T0), after 1 year (T1), and after 3 years (T2). Paired data were available for 26 subjects, seven administrative workers (AWs) and 19 plant workers (PWs). Short-term exposure was assessed by comparing start-end shift measurements. Due to the non-normal distribution of the data, the nonparametric Cuzick’s test for trend and the Wilcoxon signed-rank test for paired samples were used. Neither the trend nor the T0-T2 comparison tests resulted in statistically significant outputs in the two groups (q-value > 0.05), even when controlling for smoking habits. In relation to PWs, some of the metabolites were higher at T2 with respect to T0, but no linear increase was found. Conversely, 1-OH-PYR (ng/g creatinine) showed lower median values at T1 (61.5) and T2 (67) compared to the baseline (151.3). Similarly, short-term comparisons yielded no significant results, with rather overlapping distributions of values. Overall, no significant increases in metabolite levels were detected as a result of occupational exposure in the incinerator workers considered. These findings align with previous results for metals and ambient air measurements.
Comparative Analysis of Immune Response Genes Induced by a Virulent or Attenuated Strain of Babesia bigemina
Authors: Martínez-García Grecia , Estrada Karel , Lira-Amaya José J. , Santamaria-Epinosa Rebeca M. , Lopez-Arellano María E. , Sciutto-Conde Edda L. , Rojas-Martinez Carmen , Alvarez-Martínez Jesus A. , Sánchez-Flores Alejandro , Figueroa-Millán Julio V.
Published: January 2025

RNA-seq technology has been widely used for the characterization of the transcriptome profile induced by several diseases in both humans and animals. In the present study, RNA-seq was used to identify the differential expression of genes associated with the immune response in cattle infected with two different strains of Babesia bigemina, both derived from the same Mexican field isolate, which exhibit distinct phenotypic characteristics: the virulent strain, capable of producing acute clinical signs, and the attenuated strain, capable of stimulating a protective immune response when used as an immunogen with an efficacy greater than 80%. The differential gene expression analysis performed revealed a total of 620 differentially expressed genes (DEGs). However, the intersection of the edgeR and DESeq2 programs used in the bioinformatics analysis only identified 247 DEGs, of which 108 genes were enriched to be closely correlated with the bovine immune response based on gene ontology terms; most of the DEGs obtained encode proteins associated with the major histocompatibility complex, immunoglobulins, and T-cell surface receptors. The infection caused by the attenuated strain induced higher transcription of immune response genes compared to the infection caused by the virulent strain; nonetheless, in both infections, a greater down-regulation than up-regulation was observed. Different immunoglobulin-associated genes were found to be up-regulated in the group inoculated with the attenuated strain, whereas these were down-regulated in the virulent strain-inoculated group. In addition, an up-regulation of the HSPA6, CD163, and SLC11a1 genes was observed in the group inoculated with the virulent strain, previously reported in other Apicomplexan infections. The findings provide relevant information that could contribute to clarifying the immune response associated with an acute bovine babesiosis infection by B. bigemina.
Maternity Care Providers’ Experiences with Providing Information on Newborn Bloodspot Screening During Pregnancy: A Dutch Survey Study
Authors: Klapwijk Jasmijn E. , Gitsels-van der Wal Janneke , Martin Linda , Verschoof-Puite Rendelien K. , Elsinghorst Ellen , Henneman Lidewij
Published: January 2025

Newborn bloodspot screening (NBS) aims to detect treatable disorders in newborns to offer early interventions. According to the official Dutch national NBS guidance, parents in the Netherlands should be informed about NBS during pregnancy by maternity care providers (MCPs), providing two leaflets and oral information. This study investigated what, how, and when information about NBS is given during pregnancy according to Dutch MCPs. An online questionnaire was completed by 279 MCPs; 237 (84.9%) provided information to parents themselves, although 4.6% of them only did so postnatally, and 240 (86.0%) considered this the task of the MCP. Among the 237 MCPs, information was provided by personal conversation (59.9%) and by giving at least one leaflet (83.1%), while 25.7% only gave leaflets. Being a first pregnancy (45.1%) and parents’ literacy (38.8%) influenced how MCPs provided information. Information was mostly provided at 34–37 weeks gestation (68.8%). Conversations mostly included giving information on when NBS will be performed (97.2%), the purpose of NBS (93.7%), how the test will be performed (92.3%), and participation being voluntary (80.3%). The results suggest that while most Dutch MCPs consider it their task to provide NBS information, its timing, method, and completeness do not always follow the established guidelines.
In-Situ Polymerization for Catalytic Graphitization of Boronated PAN Using Aluminum and Zirconium Containing Co-Catalysts
Authors: Kim Taewoo , Kim Byoung-Suhk , Ko Tae Hoon , Kim Hak Yong
Published: January 2025

In-situ polymerization is an effective method for integrating co-catalysts homogeneously into the polymer matrix. Polyacrylonitrile (PAN)-derived highly graphitized carbon is a state-of-the-art material with diverse applications, including materials for energy storage devices, electrocatalysis, sensing, adsorption, and making structural composites of various technologies. Such highly graphitized materials can be effectively obtained through in-situ polymerization. The addition of external catalysts during in-situ polymerization not only enhances the polymerization rate but also facilitates the degree of graphitization and quality of graphitic carbon upon graphitization at moderate temperatures. In this study, we apply an in-situ polymerization technique to integrate aluminum triflate (Al(OTf)3) and zirconocene dichloride (C5H5)2ZrCl2 co-catalyst into a boronated polyacrylonitrile (B-PAN) matrix. The in-situ polymerization ensures the uniform distribution of the co-catalyst without aggregation, facilitating the formation of a well-ordered graphitic structure at a moderated temperature. Boronated polyacrylonitrile (B-PAN) solutions, with and without co-catalyst (Al(OTf)3, (C5H5)2ZrCl2 or both) were prepared through polymerization process, dried in an oven, and then subjected to graphitization at 1250 °C with a heating rate of 1 °C min−1 for 1 h under an N2 atmosphere. The resulting graphitic carbon was characterized to determine the impact of co-catalyst on the degree of graphitization. This study provides valuable insights into synthesizing high-quality graphitic carbon materials, offering promising pathways for their scalable production through the strategic use of in-situ polymerization and co-catalysis. These materials have potential applications in various fields, including environmental technologies, energy storage, and conversion, offering a pathway to design facile and economical graphitic carbon materials.
Heat and Cold Shocks Decrease the Incidence of Diapause in Trichogramma telengai Larvae
Authors: Voinovich Natalia D. , Reznik Sergey Y.
Published: January 2025

Insect diapause and response to thermal stress are similar in the variety of manifestations. However, the influence of thermal shocks on the incidence of insect diapause has not been sufficiently studied. Our laboratory experiments showed that both cold (−10 °C) and heat (43 °C) shocks experienced for at least 20–30 min significantly reduced the incidence of facultative larval winter diapause in the insect egg parasitoid Trichogramma telengai. However, the patterns of these responses were substantially different. In particular, the peaks of the sensitivity to diapause-averting effects of heat and of cold shocks fell, correspondingly, on middle-stage (5 days of development at 15 °C) and late-stage (9–11 days of development at 15 °C) larvae. Heat shocks influence the incidence of diapause mostly via the changes in the initial proportions of diapause-destined and non-diapause-destined individuals, whereas the effect of cold shocks is mostly based on differential mortality (i.e., the difference in mortality among treatments of the same experiment) with better survival of non-diapause-destined individuals. These results elucidate the peculiarities of the interaction between stress and diapause, allowing us to specify the methods for Trichogramma mass rearing and storage.
Machine Learning Models for the Early Real-Time Prediction of Deterioration in Intensive Care Units—A Novel Approach to the Early Identification of High-Risk Patients
Authors: Thiele Dominik , Rodseth Reitze , Friedland Richard , Berger Fabian , Mathew Chris , Maslo Caroline , Moll Vanessa , Leithner Christoph , Storm Christian , Krannich Alexander , Nee Jens
Published: January 2025

Background Predictive machine learning models have made use of a variety of scoring systems to identify clinical deterioration in ICU patients. However, most of these scores include variables that are dependent on medical staff examining the patient. We present the development of a real-time prediction model using clinical variables that are digital and automatically generated for the early detection of patients at risk of deterioration. Methods Routine monitoring data were used in this analysis. ICU patients with at least 24 h of vital sign recordings were included. Deterioration was defined as qSOFA ≥ 2. Model development and validation were performed internally by splitting the cohort into training and test datasets and validating the results on the test dataset. Five different models were trained, tested, and compared against each other. The models were an artificial neural network (ANN), a random forest (RF), a support vector machine (SVM), a linear discriminant analysis (LDA), and a logistic regression (LR). Results In total, 7156 ICU patients were screened for inclusion in the study, which resulted in models trained from a total of 28,348 longitudinal measurements. The artificial neural network showed a superior predictive performance for deterioration, with an area under the curve of 0.81 over 0.78 (RF), 0.78 (SVM), 0.77 (LDA), and 0.76 (LR), by using only four vital parameters. The sensitivity was higher than the specificity for the artificial neural network. Conclusions The artificial neural network, only using four automatically recorded vital signs, was best able to predict deterioration, 10 h before documentation in clinical records. This real-time prediction model has the potential to flag at-risk patients to the healthcare providers treating them, for closer monitoring and further investigation.
Vibration Foam Rolling Treatment Influence on Acute Changes in Plantar Flexors Muscle Temperature and Surface Emg Activity in Amateur Male Athletes
Authors: Borisavljević Aleksandar , Ćosić Marko , Janković Goran , Radić Iva , Janković Dunja , Dopsaj Milivoj
Published: January 2025

Background/Objectives: Foam rolling is widespread and deeply rooted in exercise practice. The optimal duration and role of this treatment still lack scientific consensus. A relatively novel foam rolling treatment that combines vibration during application targets different muscle characteristics that are not well understood. Studies exploring this combined treatment are scarce. The aim of this study was set to investigate the acute effects of different duration vibration (15 s, 30 s, and 60 s) foam rolling treatment (VFRt) on muscle skin temperature and surface muscle electromyography (sEMG) during Maximal Voluntary Isometric Contraction. Methods: Eighteen male subjects performed four sets of three trials of maximal isometric heel rises during three experimental sessions conducted in research laboratory. Results: Repeated measures of ANOVA determined that the muscle skin temperature significant difference was only found for the 30 s treatment (p = 0.013–0.000). For surface muscle electromyography a 30 s treatment out of all three yielded the most significant results, between pretreatment set and post-treatment set 1 (p = 0.01)—small effect size (Cohen’s d = −0.33)—and pretreatment set to post-treatment set 3 (p = 0.01)—small effect size (Cohen’s d = −0.30). Conclusions: All treatments did not produce significant differences during Maximal Voluntary Isometric Contraction heel rises, which—for practical application purposes—present a safe treatment. Future studies should investigate the acute effects of longer duration treatment on changes in surface muscle temperature. In terms of practical application, other findings suggest that muscle efficiency was improved taken into account of unchanged muscle strength along with decreased sEMG, which is beneficial. Also, the downward trend of muscle activity caused by the other two treatment durations could be of significance for practical application during rehabilitation process or during activities where this is a desired and indicated goal. In terms of targeting elevated muscle activity, 30 s of VFRt is the treatment of choice.
Cyclic Peak Extraction from a Spatial Likelihood Map for Multi-Array Multi-Target Bearing-Only Localization
Authors: Hu Chuanxing , Zhang Bo , Yang Xishan , Zhai Zhaokai , Liu Dai
Published: January 2025

In the context of multi-array multi-target bearing-only localization, due to the existence of direction-finding errors, the crossing results of bearing lines cannot accurately determine correspondence with targets. Under conditions that clutter interference and missing of detection in direction-finding, the traditional method will produce false alarm targets and miss some targets. To address this issue, this paper draws on the idea of a spatial likelihood map which calculates the likelihood of target presence at each grid point within the observation area by partitioning the observation area into grids and utilizing bearing data from each array, yielding the distribution of targets in the observation area. Then, a multi-target cyclic peak extraction algorithm based on a statistical dual-threshold is proposed, which eliminates false peaks by cyclic extraction of target positions, so as to reduce false targets. Simulation results demonstrate that the spatial likelihood mapping-based localization exhibits good performance. Furthermore, when the multi-target cyclic peak extraction algorithm based on statistical dual-thresholds is applied, it outperforms direct target extraction from the spatial likelihood map, showcasing enhanced multi-target localization capabilities. Moreover, compared to the position non-linear least squares multi-target localization method, the proposed method has lower optimal sub-pattern assignment distance and lower localization error under the condition of interference and missing detection.
Central Vascular Access Devices: Current Standards and Future Implications
Authors: Baldauf Benito , Cemin Roberto , Hummel Jana , Bonnemeier Hendrik , Assadian Ojan
Published: January 2025

Background: Central venous access devices (CVADs) are crucial for various medical conditions, but pose risks, including catheter-related bloodstream infections (CRBSI). CRBSI increases comorbidity, mortality, and healthcare costs. Surveillance and evidence-based guidelines have successfully reduced CRBSI rates, although the COVID-19 pandemic has led to increased infection rates. Main body: This review explores strategies for reducing the incidence of CRBSI and examines factors contributing to variations in reported rates across developed countries. Highlighting the significant morbidity, mortality, and healthcare resource burden associated with CRBSI, the analysis delves into evidence-backed preventive measures. It discusses the impact of the COVID-19 pandemic on infection rates and proposes resilient strategies in response to these challenges. The review emphasises the importance of understanding CRBSI pathogenesis, patient, procedure, and device-related risk factors, and the implementation of evidence-guided algorithms and surveillance measures. Recommendations include the use of all-inclusive procedure packs, ultrasound-guided placement, daily dressing changes with antimicrobial treatment, and the use of antimicrobial locks. Conclusions: The review underscores the need for clear, concise algorithms adaptable to various healthcare settings and the scalability of infection prevention systems to ensure resilience.
Thresholds for Rural Public and Ecosystem Services: Integration into Rural Green Space Spatial Planning for Sustainable Development
Authors: Yang Huiya , Zou Jiahui , Wang Chongxiao , Wu Renzhi , Ali Maroof , Huang Zhongde , Jiang Hongchao , Zhang Fan , Bai Yang
Published: January 2025

Rural landscapes are experiencing ecosystem degradation due to urbanization and rapid suburban expansion. Ecosystem services derived from natural resources and essential public services facilitated by social capital collectively address the growingly diverse social and ecological requirements of rural residents. Even so, ecosystem services and public services are often trade-offs, highlighting the necessity to enhance their coordinated development. However, it remains unclear how to use the identified thresholds to delineate functional zones. This will scientifically guide sound and efficient spatial planning and ecological management. This study takes the suburban countryside of Jiangning in Nanjing as the study area. It explores the inclusion of the threshold value of rural public services and ecosystem services in the strategic design of sustainable suburban development in China. First, we quantify and map six types of ecosystem services (ESs) and 13 types of rural public services (RPSs). Secondly, we use the piecewise linear regression method to identify the response and threshold of 13 types of RPSs to six kinds of ESs. Finally, the combination and classification of threshold values are used to divide functional areas, and space-specific management and planning suggestions are put forward. The results are as follows (1) With the increase in RPSs, all ESs respond with a downward trend. (2) In addition to the negative linear relationship between education and social welfare services and ESs, the response thresholds of other RPSs and ESs were identified. (3) According to multiple density threshold analysis of each RPS’s response to ESs, four functional areas were obtained. We emphasize the priority of spatial planning and management, that is, the priority management of “ESs enhancement area and RPSs optimization area”. (4) The threshold values of ESs and RPSs can be used as tools to delineate functional zones and guide the spatial planning and management of rural functional areas. In general, our research helps ensure the maximization of rural ecological benefits while also meeting the growing diversity of needs of rural residents and enabling efficient, phased, gradient, and precise spatial management of suburban rural ecosystems and public services to promote the sustainable development of suburban rural areas and realize rural revitalization.
Research on Territorial Spatial Use Regulation, Land Element Allocation, and Regional Fiscal Transfer Payments: An Empirical Study of the Yangtze River Economic Belt
Authors: Zhao Wanmin , Gao Yijia , Ma Aihui
Published: January 2025

The regulation of land use within territorial spaces has, to some extent, inhibited the free flow of land resources, giving rise to the dilemma of substantial losses and profits within and outside regulated areas. Investigating how to allocate “windfall profits” to compensate the regions that suffer windfall losses is of great importance for addressing regional development imbalances. This study, based on the perspective of restricted land development rights, employed an improved Cobb–Douglas (C-D) production function to analyze the differences in land input contributions between the agricultural and non-agricultural sectors. It quantified the extent of restricted land development rights, assessed their value using the opportunity cost method, and applied an economic adjustment coefficient to revise the regional fiscal transfer amounts. The results indicate the following: (1) The contribution of land factors to economic output is more significant in the non-agricultural sector than in the agricultural sector. (2) There are substantial differences in the quantities of restricted land development rights and their unit values across provinces and cities. Anhui Province has the largest restricted area, at approximately 71,945.52 hectares, while Guizhou Province has the smallest, at about 6452.62 hectares. Shanghai has the highest unit value, at around CNY 13.77 million per hectare, whereas Yunnan Province has the lowest, at approximately CNY 1.4748 million per hectare. (3) The total fiscal transfer amount for the provinces in the Yangtze River Economic Belt is about CNY 23.4 billion. Anhui Province receives the most compensation, at approximately CNY 8.5 billion, while Jiangsu Province has the highest expenditure, at about CNY 19.8 billion. Currently, the state should establish a comprehensive regional fiscal transfer compensation mechanism that takes into account the fiscal payment capacities of “windfall profit regions” and the incentive effects on “windfall loss regions” when determining fiscal transfer amounts. This approach aims to alleviate potential fiscal payment resistance in “windfall profit regions” and enhance proactive protection efforts in “windfall loss regions”, thereby achieving the coordinated development of economic growth, ecological improvement, and food security.
Histological Research and Phytochemical Characterization of Capsella bursa-pastoris Medik. from Bihor County, Romania
Authors: Onea (Minz) Sorina-Georgiana , Pallag Annamaria , Burlou-Nagy (Fati) Cristina , Jurca Tünde , Vicaș Laura Gratiela , Eleonora Marian , Olah Neli Kinga , Kiss Rita , Pașca Bianca
Published: January 2025

Capsella bursa-pastoris Medik. (CBP) is a species with antibacterial, anti-inflammatory, antioxidant, anticancer, and hepatoprotective effects. We have chosen to study this species because, although it is a common plant with a distinctive fruit appearance, its effects are not fully understood. The aim of this study was to characterize the histoanatomy of the vegetative, reproductive organs and to characterize CBP extracts in terms of bioactive compounds and its antioxidant capacity. This study investigated the quantitative chemical composition of this species using the HPLC method, revealing the total content in polyphenols, flavonoids, and anthocyanins, and investigated the antioxidant potential through fluorescence recovery after photobleaching (FRAP assay), cupric ion (Cu2+) reduction, (CUPRAC assay), and a free radical scavenging method (DPPH). Our results show that CBP is a rich source of flavonoids, mainly from the extract obtained from the fruits; it has an antioxidant capacity, with the highest values being obtained from mature flowers and ripe fruits. Of the active principles, the highest amounts, according to HPLC determinations, were obtained in flowers and are represented by hyperoside. Thus, we can recommend the studied species for phytopharmaceutical preparations.
(1R)-2,3,4,6-Tetra-O-benzyl-1-C-allyl-1-deoxy-1-C-(2-thiazolyl)-d-galactopyranose
Authors: Ferrari Clark , Dondoni Alessandro , Marra Alberto
Published: January 2025

We have previously reported that thiazolylketol acetates, synthesized by the addition of 2-lithiothiazole to sugar lactones followed by acetylation, are efficient glycosyl donors affording O-, N-, P-, and C-glycosides. After the first example of C-glycosidation recently described by us, we report here on the unexpected outcome of the reaction of a thiazolylketol acetate with allyltrimethylsilane in the presence of trimethylsilyl triflate. The obtained intermediate, an intramolecular N-thiazolium salt, could be stereoselectively converted into the desired allyl C-thiazolylketoside.
Determination of the Critical Voltage for the Observation of Uncoated Wood Samples in Electron Microscopy
Authors: Kvietková Monika Sarvašová , Dvořák Ondřej , Kubista Kryštof , Těhníková Kristýna , Lin Chia-Feng , Jones Dennis
Published: January 2025

Electron microscopy (EM) is a key tool for studying the microstructure of wood; however, observing uncoated samples poses a challenge due to surface charging. This study aims to identify the critical voltage that allows for the effective observation of uncoated wood samples without significant loading. As part of the experiment, samples of different wood species were tested, including Acacia (Robinia pseudoacacia L.), Oak (Quercus robur L.), Maple (Acer pseudoplatanus spp.), Ash (Fraxinus excelsior L.), Spruce (Picea abies (L.) Karst.), Thermowood (Thermal modifed Spruce), Garapa (Apuleia leiocarpa), Ipé (Handroanthus spp.), Merbau (Intsia bijuga), and Massaranduba (Manilkara spp.). Several methods were tested for surface preparation for SEM analysis, including the use of a circular saw, a hand milling machine, and a microtome. The results show that the optimal voltage for observing uncoated wood samples varied depending on the wood species. Regarding the selection of wood species and the results obtained, it was found that uncoated samples could be effectively observed. This finding suggests that practical observations can be accelerated and more cost-effective, as all wood species exhibited the required voltage range of 1 kV to 1.6 kV. Additionally, it was determined that using a secondary electron detector was optimal for such observations, as it provided a sufficiently strong signal even at relatively low voltages. Conversely, when using a backscattered electron detector, it was more beneficial to use coated samples to achieve a sufficient signal at higher voltages. This study brings new knowledge that will facilitate further research and applications of electron microscopy in the study of other wood species or wood-based materials.
Biomechanical Behaviors of Molars Restored with Endocrowns Composed of Different Materials
Authors: Li Zhi , Zhu Junxin , Xu Yongxiang , Bao Xudong , Wang Xiaoyan
Published: January 2025

To assess the biomechanical behaviors of endodontically treated molars (ETMs) restored with endocrowns composed of different materials, forty mandibular molars were assigned to five groups (n = 8 each). Untreated molars constituted the control group (group C); the rest of the teeth that underwent root canal therapy were restored with endocrowns composed of polycrystalline ceramics (ST zirconia®, UPCERA) in group ZR, lithium disilicate glass ceramics (UP.CAD®, UPCERA) in group LD, resin-based nanoceramics (Hyramic®, UPCERA) in group NC, and feldspathic ceramics (CEREC Blocs®, Sirona) in group FC. All teeth were axially loaded until fracture. The process was recorded using a high-speed camera system, and fractographic analysis was conducted. The results showed that fracture loads did not significantly differ among groups C, LD, and NC; the loads were significantly lower than the load in group ZR but higher than the load in group FC. The mean time from the initial crack to complete tooth fracture varied. Group C had the longest time, followed by group NC; groups ZR, LD, and FC had the shortest time. Similar failure patterns were observed in groups ZR and LD, which were more regular than the pattern in group NC; group FC exhibited the roughest fracture surfaces. Fracture resistance testing combined with a high-speed camera system and fractographic analysis provides a promising modality for studying the biomechanical behaviors of restored teeth. Endocrowns composed of lithium disilicate glass ceramics or resin-based nanoceramics offer alternative restorations for ETMs with extensive coronal loss.