bluuebunny/crossref_metadata_2025 huggingface dataset:
Liver Stiffness Measurement With FibroScan: Use the Right Probe in the Right Conditions!
Authors: Berger Arthur , Shili Sarah , Zuberbuhler Floraine , Hiriart Jean-Baptiste , Lannes Adrien , Chermak Faiza , Hunault Gilles , Foucher Juliette , Oberti Frederic , Fouchard-Hubert Isabelle , Cales Paul , de Ledinghen Victor , Boursier Jerome
Published: April 2019

INTRODUCTION:

FibroScan's M and XL probes give significantly different results, which could lead to misevaluation of liver fibrosis if the correct probe is not chosen. According to the manufacturer, the M probe should be used when the skin–liver capsule distance (SCD) is <25 mm, and the XL probe should be used when SCD is ≥25 mm. We aimed at validating this recommendation and defining the conditions of use for FibroScan probes in clinical practice.

METHODS:

Four hundred thirty-nine patients with biopsy-proven chronic liver disease were included. Of them, 382 had successful examinations with both M and XL probes. Advanced fibrosis was defined as Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) F ≥3 or Metavir F ≥2.

RESULTS:

In a same patient, XL probe results were significantly lower than M probe results: 7.9 (5.6–11.7) vs 9.5 (6.7–14.6) kPa, respectively (P < 0.001). After matching for age, sex, liver fibrosis, and serum transaminases, M probe results in patients with SCD <25 mm and XL probe results in those with SCD ≥25 mm did not significantly differ: 8.8 (6.0–12.0) vs 9.1 (6.7–12.8) kPa, respectively (P = 0.175). Of note, 81.4% of patients with body mass index (BMI) <32 kg/m2 had SCD <25 mm, and 77.7% of patients with BMI ≥32 kg/m2 had SCD ≥25 mm. A practical algorithm using BMI first and then the FibroScan Automatic Probe Selection tool was proposed to help physicians accurately choose which probe to use in clinical practice.

CONCLUSIONS:

There is no significant difference in results between M and XL probes when they are used in the right conditions. In clinical practice, the probe should be selected according to the BMI and the Automatic Probe Selection tool.
A Persian version of the Affiliate Stigma Scale in caregivers of people with dementia
Authors: Saffari Mohsen , Lin Chung-Ying , Koenig Harold G. , O’Garo Keisha-Gaye N. , Broström Anders , Pakpour Amir H.
Published: April 2019

Background: Dementia is prevalent among older adults and frequently causes dependence on family caregivers. Caregivers may experience a form of stigmatization called affiliate stigma that negatively affects their mental health. The current study sought to establish the psychometric properties of a tool to measure affiliate stigma among Iranian caregivers. Methods: Overall, 541 caregivers of older people with dementia were included in this cross sectional study. Several measures were used to assess the psychometric properties of the Affiliate Stigma Scale (ASS) including the Zarit Burden Interview (ZBI), Hospital Anxiety and Depression Scale (HADS), Short Form 12 (SF-12), Rosenberg Self-Esteem Scale (RSES), and Multidimensional Scale of Perceived Social Support (MSPSS). Convergent and discriminate validity were examined.Exploratory and confirmatory factor analyses were utilized to assess the factor structure of the Ass and a Rasch model was used to evaluate the measurement functioning of the scale. Results: Factor loadings ranged from 0.69 to 0.83 and test-retest reliability from 0.72 to 0.89.Item difficulty ranged widely from -0.66 to 0.89. No considerable differential item functioning (DIF) was found across gender. Confirmatory factor analysis confirmed the three cognitive,effective, and behavioral dimensions of the scale (comparative fit index [CFI]=0.931 to 0.995,root mean square error of approximation [RMSEA]=0.046 to 0.068). Internal consistency was acceptable (Cronbach’s α: 0.88 to 0.94). Significant and positive relationships were found between affiliate stigma and depression, anxiety, and care giving burden (β =0.35 to 0.46). Conclusion: The ASS is a psychometrically valid measure for assessing affiliate stigma in Iranian caregivers of people with dementia. Application of this tool among other caregivers, language sand cultures deserves further study.
Effects of an educational playful intervention on nasal hygiene behaviors of preschoolers: a quasi-experimental study
Authors: Costa Priscila , Ermini Talita , Sigaud Cecilia Helena de Siqueira
Published: April 2019

Background: To determine the effects of an educational playful intervention on nasal hygiene behaviors among preschool (3-4 years old) children. Methods: A quasi-experimental before-after study was conducted with 39 children attending public daycare center in Sao Paulo, Brazil. A group-based intervention consisted of two educational sessions to promote healthy behaviors for nasal hygiene. It was adopted playful strategies such as a story told by puppets, card games and simulation of nasal hygiene in front of the mirror. The outcome was evaluated by observing six healthy behaviors for nasal hygiene one week before and after the intervention. Differences in the outcome before and after the intervention were tested using Wilcoxon signed rank test and McNemar’s test. Results: The median of healthy nasal hygiene behaviors went from 3.0 to 4.0 after the intervention, with a significant statistical difference (P=0.0004) and a difference of behaviors. After the intervention, forcing the air out of one opened nostril increased from 5.1%to 30.8% (P=0.001, CI 95%: 0-0.440), forcing the air out of the other nostril increased from 5.1% to 28.2% (P=0.003/CI 95%: 0-0.50), throwing the piece of toilet paper in the garbage increased from 53.8% to 87.21% (P=0.04, CI 95%: 0.035-0.65), and sanitizing the hands with soap and water increased from 15.4% to 43.6% (P=0.039-0.76). Conclusion: the educational playful intervention improved the autonomy of preschoolers to adopt healthy nasal hygiene behaviors.
Intervening to reduce sedentary behavior in older adults – pilot results
Authors: Koltyn Kelli F. , Crombie Kevin M. , Brellenthin Angelique G. , Leitzelar Brianna , Ellingson Laura D. , Renken Jill , Mahoney Jane E.
Published: April 2019

Background: Older adults spend most of their day in sedentary behavior (SB) (i.e., prolonged sitting), increasing risk for negative health outcomes, functional loss, and diminished ability for activities of daily living. The purpose of this study was to develop and pilot test an intervention designed to reduce SB in older adults that could be translated to communities. Methods: Two pilot studies implementing a 4-week SB intervention were conducted. SB,physical function, and health-related quality of life were measured via self-report and objective measures. Participants (N=21) completed assessments pre- and post-intervention (studies 1 and 2) and at follow-up (4-weeks post-intervention; study 2). Due to the pilot nature of this research, data were analyzed with Cohen’s d effect sizes to examine the magnitude of change in outcomes following the intervention. Results: Results for study 1 indicated moderate (d=0.53) decreases in accelerometry-obtained total SB and increases (d=0.52) in light intensity physical activity post-intervention. In study 2,there was a moderate decrease (d=0.57) in SB evident at follow-up. On average SB decreased by approximately 60 min/d in both studies. Also, there were moderate-to-large improvements in vitality (d=0.74; study 1) and gait speed (d=1.15; study 2) following the intervention. Further,the intervention was found to be feasible for staff to implement in the community. Conclusion: These pilot results informed the design of an ongoing federally funded randomized controlled trial with a larger sample of older adults from underserved communities. Effective,feasible, and readily-accessible interventions have potential to improve the health and function of older adults.
Quality of Life in Women with Cancer and Its Influencing Factors
Authors: Sheikhalipour Zahra , Ghahramanian Akram , Fateh Alavieh , Ghiahi Rasol , Onyeka Tonia C
Published: April 2019

Introduction: Studies show that some of the factors such as pain and psychological changes could decrease the quality of life of patients with cancer. The understanding of these factors can enhance the effectiveness and process of cancer treatment. Therefore this study was conducted to investigate the quality of life in women with cancer and its influencing factors. Methods: This was a cross-sectional study which was carried out in the city of Tabriz in the northwestern part of Iran in 2016. The sample consisted of 150 women diagnosed with cancer. The EORTC QLQ-C30 (version 3) was used for evaluating the quality of life of the women. The collected data were analyzed in the SPSS ver. 13 using descriptive and inferential statistics. Also, t-test and ANOVA test were applied to investigate the correlation between the dimensions of quality of life and socio-demographic variables. P < 0.05 denoted as statistically significant. Results: The results showed that the quality of life in the function and symptoms dimensions were in acceptable levels. In the function dimension, the highest and lowest scores belonged to the cognitive and emotional domains, respectively. Also, those women who had the symptoms of insomnia and fatigue, and reported the pressure due to financial burden of cancer treatment had a significantly lower quality of life. A low score was reported in general health dimension. No statistically significant relationships were reported between the socio-demographic characteristics and the women’s quality of life and its dimensions. Conclusion: Since sleeplessness and fatigue reduce the quality of life in women with cancer, nursing interventions are required to relieve cancer-related symptoms. The financial burden of cancer treatment is high. Therefore, governmental and insurance agencies should help with the costs paid by the patients and prevent from reducing their quality of life.
Lived Traumatic Childbirth Experiences of Newly Delivered Mothers Admitted to the Postpartum Ward: a Phenomenological Study
Authors: Abdollahpour Sedigheh , Motaghi Zahra
Published: April 2019

Introduction: Childbirth is a stressful event in every woman's life, leading to traumatic deliveries in half of the cases. This study aimed at describing mothers’ lived experiences which make them perceive their childbirth as traumatic. Methods: In this descriptive phenomenological study, based on the DSM-V-A criteria, 32 mothers who had perceptions of a traumatic event during their labor and delivery were explored through semi-structured interviews, and the collected data were analyzed using the Colaizzi’s method. Results: Four main themes could be extracted from the experiences of the mothers. The first theme was sensational and emotional experiences followed by clinical experiences, legal experiences and human dignity, and environmental experiences. The sensational and emotional experiences included four main categories (anxiety, fear, sorrow, anger). The theme of clinical experiences included two main categories (avoidable and unavoidable childbirth complications). The theme of legal experiences and human dignity included two main categories (non-observance of the charter of patient rights, and non-observance of human rights). The theme of environmental experiences also included two main categories (lack of proper supervision and management). Conclusion: To prevent traumatic childbirth and its negative effects, different psychological aspects of childbirth need to be identified.
A Systematic Review on the Anxiolytic Effect of Aromatherapy during the First Stage of Labor
Authors: Ghiasi Ashraf , Bagheri Leila , Haseli Arezoo
Published: April 2019

Introduction: Anxiety is the most common psychological response of women to labor. The aim of the present systematic review was to evaluate and summarize the available clinical evidence on the anxiolytic effects of aromatherapy during the first stage of labor. Methods: Electronic databases including: Cochrane Library, MEDLINE/ PubMed, Scopus, CINAHL, SID, Iran Doc, ProQuest, and Google Scholar were searched up to Sep10, 2017 with the keywords of 'aroma*', 'aromatherapy', 'essential oil', 'anxiety', and ' labor '. The risk of bias in the included studies was assessed using the Cochrane Collaboration's 'Risk of bias' tool. The results were reported qualitatively. Results: A total of 14 published papers and 2 unpublished papers were retrieved which met the inclusion criteria. The studies were conducted in Iran, Egypt, Korea, and Italy. Essential oils had been used were lavender in 5 articles, rose, clary sage, geranium and frankincense in 3 articles, chamomile, bitter orange, sweet orange and peppermint in 2 articles, mandarin orange, jasmine and clove in 1 article. A majority of the studies suggested a positive effect of aromatherapy in reducing women's anxiety during the first stage of labor. Conclusion: It is recommended that aromatherapy could be applied as a complementary therapy for reducing anxiety during the first stage of labor, but methodologically rigorous studies should be conducted in this area.
Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography
Authors: Dhungana Sahadeb Prasad , Karki Prahlad , Lamsal Madhab
Published: April 2019

Introduction: Data suggest that brain natriuretic peptide (BNP) and NT pro-BNP partially reflect ventricular pressure and could have a role in the early detection of diastolic abnormalities in hypertensive patients with normal systolic function. This study aimed to assess the role of NT pro-BNP for early detection of diastolic dysfunction in patients with hypertension and to correlate its level with echocardiographic parameters of diastolic dysfunction. Methods: This is a comparative cross-sectional study. Hundred cases of asymptomatic hypertensive patients with normal left ventricular (LV) systolic function and 100 healthy subjects were subjected to echocardiography and measurement of serum NT-pro BNP who received care at outpatient department of internal medicine, B.P. Koirala Institute of health sciences, Nepal. Results: Both systolic and diastolic blood pressures were significantly higher (≥160 and/or 100 mm Hg) in cases compared to controls (<120/80 mm Hg). Echocardiographic parameters of diastolic dysfunction: E/A ratio, E/E’ratio, deceleration time and isovolumetric relaxation time showed a significant difference between cases and controls. Mean serum NT-proBNP was significantly higher in patients with hypertension (213.19 ±184.3 pg/mL) compared to controls (58.51 ± 11.01 pg/mL) (P=0.008). There was no significant difference in mean serum NT-pro BNP levels between cases with no LV diastolic dysfunction (n=14) and controls (n=100) but it showed a significant difference between cases with LV diastolic dysfunction of all grades (n=86) and controls (n=100) (P=0.00). NT-proBNP levels were higher in both group of patients with E/A ratios <0.9 and 0.9-1.5 (245.72 ± 166.73 pg/mL and 210.69 + 143.53 pg/mL respectively) as compared to controls. Mean serum NT-proBNP levels were significantly higher in patients with IVRT >90 ms (270.43 ± 180.81 pg/mL) as compared to controls (P=0.03) but the difference was not significant between cases with IVRT of 60-90 ms (152.02 ± 100.23 pg/mL) and controls (P=0.09). NT-proBNP levels were significantly higher in all groups of patients with E/E’ ratios <8, 8-12, >12 (197 ± 121.25 pg/mL, 263.12 ± 122.52 pg/mL and 180 ± 106.56 pg/mL respectively) compared to controls. Conclusion: Mean serum NT-proBNP was significantly higher in patients with hypertension as compared to controls. There is some correlation between echocardiographic parameters of diastolic dysfunction and serum NT-proBNP. Hence, NT-proBNP may be useful for early detection of LV diastolic dysfunction in patients with hypertension.
Factors related to the non-adherence of medication and nonpharmacological recommendations in high blood pressure patients
Authors: Etebari Farzane , Pezeshki Mohammad Zakaria , Fakour Sanam
Published: April 2019

Introduction: Many studies have been conducted on non-adherence with the antihypertensive treatment regime in various countries, considering the burden of cardiovascular disease (CVD) on the public health system, it is essential to carry out studies in this regard. Methods: Patients with hypertension evaluated at the family medicine clinic of Tabriz University of Medical Sciences were enrolled using simple sampling. Data gathering tool was a questionnaire consisting of three sections including the Hill-Bone compliance questionnaire, the disease characteristics, and patients’ socioeconomic. Results: Of 254 patients with hypertension, gender, income satisfaction, the occupation and the level of education did not correlate with the acceptance of the treatment. However, the number of antihypertensive medications had a significant effect on adherence with dietary orders and appointment keeping (P<0.01 and P=0.01, respectively). The number of antihypertensive drugs could statistically significantly predict overall score obtained from the questionnaire, F (1, 251) = 22.29, P<0.018. Conclusion: Factors related to the history of the disease and socioeconomic status had no effect patients adherence with treatment; however, the number of the prescribed antihypertensive drugs is in association with higher overall scores obtained through the Hill-Bone questionnaire.
Comparison of tracheal tube cuff pressure with two technique: fixed volume and minimal leak test techniques
Authors: Sanaie Sarvin , Rahmani Farzad , Chokhachian Sara , Mahmoodpoor Ata , Rahimi Panahi Jafar , Mehdizadeh Esfanjani Robab , Mirzaei Masomeh , Soleimanpour Hassan
Published: April 2019

Introduction: There is a correlation between endotracheal cuff pressure and airway complication; therefore, cuff pressure measurement is of an essential importance. The gold standard technique is measuring the cuff pressure by a calibrated manometer. However, there are several methods that injects air into balloon pilot and measures the cuff pressure. The aim of this study is to compare the tracheal cuff pressure measurement by two methods: fixed volume and minimal leak test (MLT). Methods: This descriptive study was performed at the emergency department on 110 patients. Patients were randomized into two groups. For one group, fixed volume technique and for the other group MLT was used. Results: Mean cuff pressure was 46.07±23.54 cmH2O in the fixed volume group and 33.72±9.14 cmH2O in the MLT group (P=0.05) which is significantly higher in the fixed volume group (P=0.028). In addition, 56.4% and 78.2% of the subjects had normal cuff pressure in the fixed volume group and MLT group, respectively; indicating a significantly higher rate in MLT group (P=0.025). Conclusion: Both techniques cause above normal intracuff pressure; however, MLT produces more acceptable pressure than fixed volume. It seems that the volume of 10 cc produces high pressures; therefore, fixed values may yield more appropriate results in lower volumes.
Is normal body mass index a good indicator of metabolic health in Azar cohort population?
Authors: Somi Mohammd Hossein , Nikniaz Zeinab , Ostadrahimi Alireza , Eftekhar Sadat Amir Taher , Faramarzi Elnaz
Published: April 2019

Introduction: Metabolic syndrome (Mets) has become most important public health problem in the world. We examined the association between Mets and different cardiometabolic phenotype in Azar cohort population. Methods: In the present study, the data of 13099 subjects who participated in Azar cohort study were cross-sectionally analyzed. Mets was defined according to the National Cholesterol Education Program’s Adult Treatment Panel III report (ATPIII) criteria. Participants were categorized into four cardiometabolic phenotypes including metabolically healthy Lean (MHL), metabolically unhealthy lean (MUHL), metabolically healthy Obese (MHO), metabolically unhealthy obese (MUHO) according to BMI cut–off point (25 kg/m2 ), and the presence of Mets. Results: Totally, the prevalence of Mets was 33.20% with the higher prevalence in women (40.1%). About 46.7% of participants were MHO and 1.6% of them were MHL. In both genders, MUHL had the highest prevalence of hyperglycemia, hypertrigliceridemia, hypo-HDL-cholestrolemia and Frahmingham 10-year CVD risk. In both MUHL and MUHO phenotypes, hypertriglyceridemia (OR: 31.97 [95% CI: 22.31, 45.81] and OR: 20.28 [95% CI: 17.32, 23.75]) and hypo-HDL cholestrolemia (OR:27.97 [95% CI: 17.35, 45.09] and OR:11.0 [95% CI: 9.62, 12.58]) are the strongest predictor of incidence of Mets. Also, the results of multinominal regression analyses indicated that in all cardiometabolic phenotypes, Framingham 10- year CVD risks had the lowest power for predicting of Mets incidence. Conclusion: Based on the results, in addition to obese individuals, multiple metabolic abnormalities were seen in normal weight individuals and these subjects are even at higher risk of developing Mets compared with metabolically obese individuals. So, it seems that decision on initiation of lifestyle interventions should not be only based on the BMI; rather metabolic status seems to be even more important.
Isolated inferior vena cava aneurysm: a case report
Authors: Tadayon Niki , Kalantar-Motamedi Seyyed Mohammadreza , Zarrintan Sina , Tayyebi Ali
Published: April 2019

We report a rare case of inferior vena cava (IVC) aneurysm in a 22-year old Afghan-Iranian male patient. CT scan illustrated a saccular aneurysm of IVC originating from right side of the IVC below the renal veins (a saccular type 3 IVC aneurysm). We planned open resection and repair of the aneurysm. The patient had well recovery after the operation and his follow-up did not reveal any morbidity. IVC aneurysm is a rare clinical entity. Its diagnosis necessitates precise clinic suspicion and the management is based on anatomical location and associated anomalies.
Cardiac hydatid cyst: A rare presentation of echinococcal infection
Authors: Firouzi Ata , Neshati Pir Borj Mohsen , Alizadeh Ghavidel Alireza
Published: April 2019

A 57–year-old man presented with atypical chest pain. Transthoracic echocardiography was performed and revealed a very large and well defined intra-myocardial multicystic mass in the posterolateral and basal inferoseptal segments of left ventricle suggestive of hydatid cyst. Although the echocardiographic diagnosis was straightforward, serologic test (hydatid cyst antibody) with enzyme-linked immunosorbent assay (ELISA) was performed which was positive for echinococcal infection. Other works up showed no involvement of other organ system. Albendazol was started for him and he referred to cardiac surgeon for resection of cystic mass.
Chromatographic Method for Determination of the Amino Acid Content in Dioscorea bulbifera L. Tubers by RP-HPLC
Authors: Bhat Musadiq Hussain , Fayaz Mufida , Kumar Amit , Dar Alamgir Ahmad , Jain Ashok Kumar
Published: April 2019

Background: The present study was carried out for determination of amino acid content in tubers of Dioscorea bulbifera using reverse-phase high-performance liquid chromatography. Methods: The method involved the vapor phase hydrolysis of the sample, automated derivatisation of the amino acids with the aid of AccQ-Fluor reagent kit, separated on a high performance liquid chromatography equipped with photo diode array (HPLC-PDA) at 254 nm having column temperature of 37 ºC. Results: The proportional molar concentration for each amino acid was calculated based on the concentration of standard amino acids and expressed as μg amino acid/mg sample. Methionine, aspartic acid and leucine were major components while as tyrosine was found minor from the plant on dry weight basis. Conclusion: The method is reliable, simple and economical for determining the amino acid content of Dioscorea bulbifera tubers.
Isolation and Identification of Antibiotic-Producing Halophilic Bacteria from Dagh Biarjmand and Haj Aligholi Salt Deserts, Iran
Authors: Elyasifar Babak , Jafari Sevda , Hallaj-Nezhadi Somayeh , Chapeland-leclerc Florence , Ruprich-Robert Gwenaël , Dilmaghani Azita
Published: April 2019

Background: Halophilic bacteria are potent organisms in production of novel bioactive antimicrobial compounds which might be considered in drug innovation and control of plant pathogens. Salt deserts in Semnan province are of the most permanent hypersaline areas in the North of Iran. Despite the importance of these areas, there is no scientific report regarding the biodiversity and potency of their halophilic bacteria. Thus, aforementioned areas were selected to detect the halophilic bacteria. Methods: Here, seven strains were isolated and cultured on their molecular and biochemical properties were characterized. To determine the antibiotic potency of the isolates, agar well diffusion method was conducted. Phylogenetic analysis was done to reveal the isolates relationship with previously known strains. Results: As a result, growth of the strains in the medium containing 5 to 20% (w/v) NaCl determined that the majority of the isolates were moderately halophile. Catalase activity of all strains was positive. The results represented that D6A, Dar and D8B have antimicrobial effects against different plant and human pathogens. Phylogenic tree analysis also showed that two strains of D6A and Dar are belonged to Bacillus subtilis and D8B is belonged to Virgibacillus olivae. The bacteria extracts were evaluated for their antifungal and antibacterial activities on human and Plant pathogenic strains. The MIC of the extract B. subtilis against was found active against human pathogenic fungi and Plant pathogenic bacteria and fungi, ranging from 12.5 to 25 µg/mL. Conclusion: This study highlights the therapeutic and prophylactic potential of B. subtilis extracts as antibacterial and antifungal agents.
Evaluation of the Effects of Chronic Administration of Citrus aurantium Essential Oil on the Development of Tolerance and Dependence to Morphine
Authors: Parvizpur Alireza , Parnian Kosar , Samankan Sama , Fathiazad Fatemeh , Charkhpour Mohammad
Published: April 2019

Background: Long-term exposure to opioids may lead to physical dependence and tolerance. The purpose of this study was to investigate the effects of Citrus aurantium essential oil (CEO) on the morphine-induced tolerance and dependence. Methods: To evaluate morphine tolerance, the experiments were carried out in 6 rat groups (n=8) in the weight range of 225-275 g. The control group received morphine (10 mg/kg/day) and the test groups received morphine with the different doses of essential oil (CEO 20, 40 and 80 mg/kg/day) or 4 mL/kg of essential oil vehicle (KolliphorÒ HS15 30% in normal saline that adjusted in pH=7.4 with phosphate buffer) intraperitoneally. The hot-plate test was carried out every other day, 90 minutes after the injections. To examine morphine withdrawal, male Wistar rats were divided into seven groups (n=8) randomly, including: morphine sulphate, CEO (20, 40 and 80 mg/kg) + morphine, vehicle of CEO + morphine. The rats were rendered morphine-dependent by injection of additive doses of morphine subcutaneously for 9 days. The procedure of the morphine administration was as following protocol: day1: 5 mg/kg/12h, day 2 and 3: 10 mg/kg/12h, day 4 and 5: 15 mg/kg/12h, day 6 and 7: 20 mg/kg/12h and day 8 and 9: 25 mg/kg/12h. In the 9th day, 2 hours after the last dose of morphine, naloxone (4 mg/kg) was injected intraperitoneally. Some withdrawal behaviors were counted for 60 minutes. Results: Morphine tolerance was completed after 5 days in the control group. The vehicle group showed tolerance on the 9th day (p-value=0.991), 20mg group in the 13th day (p-value to control=0.010, to vehicle=0.049), 40 mg group on the 15th day (p-value to control and vehicle<0.001) and 80 mg group on the 13th day (p-value to control= 0.001, to vehicle= 0.007). The results showed that CEO could reduce the morphine withdrawal syndrome and total withdrawal score (TWS). Intraperitoneally injection of CEO in two doses (40 mg/kg with p<0.001 and 80 mg/kg with p<0.01) significantly reduced the TWS in comparison to the morphine+vehicle treated group. Conclusion: The results indicated that chronic administration of C. aurantium essential oil extracted had beneficial effects in reducing morphine withdrawal syndrome and could significantly delay tolerance to morphine.
Inhibitory Effect of Hydroxymethylfurfural in Viability of BALB/C Mice Splenocytes
Authors: Saleh-Ghadimi Sevda , Jafari-Vayghan Hamed , Kheirouri Sorayya , Alizadeh Mohammad
Published: April 2019

Background: This study was designed to discover if hydroxymethylfurfural (HMF) exposure modifies cell proliferation and DNA damage in BALB/c mice splenocytes. Methods: Mitogenesis in T cells and B cells was induced by Concanavalin A (Con A) and lipopolysaccharide (LPS). The colorimetric tetrazolium assay was used to evaluate cell proliferation. DNA damaging consequences were evaluated via measurement of 8-hydroxy-2-deoxyguanosine (8-OHdG) level in BALB/c mice splenocytes. Results: Spleen cells proliferation elicited by ConA, was dramatically suppressed by 25, 50 and 100 mM of HMF. However, there was not any significant difference between various concentrations of HMF. The same result was observed following treatment with LPS and HMF in different concentrations. Eight-OHdG concentration was elevated significantly in HMF treated groups compared with untreated control and mitogens. Conclusion: HMF was found to have immunosuppressing and DNA damaging properties in mM concentrations in mice splenocytes.
Human Gyrovirus Apoptin as a Potential Selective Anticancer Agent: An In Vitro Study
Authors: Akbari Amir , Arabsolghar Rita , Behzad Behbahani Abbas , Rafiei Dehbidi Gholamreza , Zare Farahnaz , Hadi Mahdieh
Published: April 2019

Background: Selective therapy has always been the main challenge in cancer treatments. Recently, it has been shown that Human Gyrovirus-derived protein apoptin (HGV-Apoptin) has selective cytotoxic effects on cancer cells similar to its homologue, Chicken Anemia Virus-derived Apoptin (CAV-Apoptin). However, apoptotic effects of Human Gyrovirus apoptin have been only evaluated on a few cancerous cell lines and need to be further investigated. In this study, we have evaluated the apoptotic effects of HGV-Apoptin and CAV-Apoptin expression on lung cancer (A549) and normal (HEK-293) cell lines, in order to provide more information about the specificity of these proteins on cancerous cells. Methods: Target cells were transfected by the calcium-phosphate precipitation method with constructed plasmids expressing HGV-Apoptin and CAV-Apoptin proteins as well as the control plasmid. Transfection efficiency was followed and imaged by fluorescence microscopy. Quantification of apoptosis was performed by flow cytometry. Measurements were compared by paired Student t-test. Results: Cells were successfully transfected with control and constructed plasmids. Flowcytometry analysis showed that A549 cells transfected with HGV-Apoptin and CAV-Apoptin expressing plasmids, undergone the apoptosis compared to A549 cells transfected with control plasmid (P<0.001). None of the plasmids could induce apoptosis in HEK-293 cells. Conclusion: Human Gyrovirus-derived apoptin (HGV-Apoptin) similar to its homologue, chicken anemia virus derived Apoptin (CAV-Apoptin) can induce apoptosis in Non-small-cell lung carcinoma cell line A549, but not in normal human embryonic kidney cell line HEK-293, which can be introduced as a promising novel specific antitumor agent.
Influence of High- and Low-Frequency Resistance Training on Lean Body Mass and Muscle Strength Gains in Untrained Men
Authors: Franco Cristiane M.C. , Carneiro Marcelo A.S. , de Sousa Jairo F.R. , Gomes Gederson K. , Orsatti Fábio L.
Published: April 2019

Franco, CMC, Carneiro, MAS, de Sousa, JFR, Gomes, GK, and Orsatti, FL. Influence of high- and low-frequency resistance training on lean body mass and muscle strength gains in untrained men. J Strength Cond Res 35(8): 2089–2094, 2021—The aim of this study was to investigate whether high-frequency resistance training (HFRT) performs better in lean body mass (LBM) and muscle strength gains when compared with low-frequency resistance training (LFRT). Eighteen untrained males (height: 1.76 ± 0.05 m, body mass: 78.3 ± 13.5 kg, and age: 22.1 ± 2.2 years) were randomly allocated into HFRT (n = 9) and LFRT (n = 9). Muscle strength {1 repetition maximum (RM) (bench press [BP] and unilateral leg extension [LE])} and LBM (DXA) were assessed at before and after 8 weeks of training. Both groups performed 7 whole-body resistance exercises, standardized to 10 sets per week, 8–12 maximal repetitions, and 90–120 seconds of rest in a 5-day resistance training routine. The LFRT performed a split-body routine, training each specific muscle group once a week. The HFRT performed a total-body routine, training all muscle groups every session and progressed from a training frequency of once per week to a training frequency of 5 times per week. Lean body mass increased without differences between groups (HFRT = 1.0 kg vs. LFRT = 1.5 kg; p = 0.377). Similarly, 1RM increased without differences between groups (right LE, HFRT = 21.2 kg vs. LFRT = 19.7 kg, p = 0.782; BP, HFRT = 7.1 kg vs. LFRT = 4.5 kg, p = 0.293). These findings suggest that in young untrained men, progressing from a training frequency of once per week to a training frequency of 5 times per week with equated volume produces similar gains in LBM and muscle strength as a constant training frequency of once per week, over an 8-week training period.
Comparing Biomechanical Time Series Data During the Hang-Power Clean and Jump Shrug
Authors: Kipp Kristof , Comfort Paul , Suchomel Timothy J.
Published: April 2019

Kipp, K, Comfort, P, and Suchomel, TJ. Comparing biomechanical time series data during the hang-power clean and jump shrug. J Strength Cond Res 35(9): 2389–2396, 2021—The purpose of this study was to investigate differences in the force-, velocity-, displacement-, and power-time curves during the hang-power clean (HPC) and the jump shrug (JS). To this end, 15 male lacrosse players were recruited from a National Collegiate Athletic Association Division-I team, and performed one set of 3 repetitions of the HPC and JS at 70% of their HPC 1 repetition maximum (1RM HPC). Two in-ground force plates were used to measure the vertical ground reaction force (GRF) and calculate the barbell-lifter system mechanics during each exercise. The time series data were normalized to 100% of the movement phase, which included the initial countermovement and extension phases, and analyzed with curve analysis and statistical parametric mapping (SPM). The SPM procedure highlighted significant differences in the force-time curves of the HPC and JS between 85 and 100% of the movement phase. Likewise, the SPM procedure highlighted significant differences in the velocity- and power-time curve of the HPC and JS between 90 and 100% of the movement phase. For all comparisons, performance of the JS was associated with greater magnitudes of the mechanical outputs. Although results from the curve analysis showed significant differences during other periods of the movement phase, these differences likely reflect statistical issues related to the inappropriate analysis of time series data. Nonetheless, these results collectively indicate that when compared with the HPC, execution of the JS is characterized by greater GRF and barbell-lifter system velocity and power outputs during the final 10% of the movement phase.
Anaerobic Threshold in a Water-Based Exercise: Agreement Between Heart Rate Deflection Point and Lactate Threshold Methods
Authors: Alberton Cristine L. , Andrade Luana S. , Pinheiro Rochele B. , Pinto Stephanie S.
Published: April 2019

Alberton, CL, Andrade, LS, Pinheiro, RB, and Pinto, SS. Anaerobic threshold in a water-based exercise: agreement between heart rate deflection point and lactate threshold methods. J Strength Cond Res 35(9): 2472–2478, 2021—The purpose of this study was to compare and assess the agreement of the heart rate (HR) and rating of perceived exertion (RPE) corresponding to the anaerobic threshold (AT) between HR deflection point (HRDP) and lactate threshold (LT) methods during a water-based exercise in young men. Sixteen young men (24 ± 6 years) performed the experimental protocol, which comprised the performance of a maximal incremental test during the water-based stationary running exercise. The initial cadence corresponded to 90 b·min−1, with 10 b·min−1 increases every 3 minutes up to exhaustion. Heart rate was monitored every 30 seconds while blood lactate concentrations and RPE were measured at the end of each 3-minute bout. Anaerobic threshold was identified by HRDP and LT methods by experienced physiologists. Paired Student's t-test, Bland-Altman analysis, and Pearson correlation were used for data analysis (α = 0.05). As results, there was agreement between HRDP and LT methods for HR, while RPE presented significant higher values for the HRDP method, resulting in an absence of acceptable agreement between methods. In addition, strong relationships (p ≤ 0.001) were verified between methods of AT determination for HR (r = 0.786) and RPE (r = 0.916). Therefore, based on the agreement between HRDP and LT methods, the HR determined by HRDP may be a valid parameter used for the intensity prescription of water-based stationary running exercise in young men during water aerobics programs and may be considered more reliable than RPE.
Transference Effect of Short-Term Optimum Power Load Training on the Punching Impact of Elite Boxers
Authors: Loturco Irineu , Pereira Lucas A. , Kobal Ronaldo , Fernandes Victor , Reis Valter P. , Romano Felipe , Alves Mateus , Freitas Tomás T. , McGuigan Michael
Published: April 2019

Loturco, I, Pereira, LA, Kobal, R, Fernandes, V, Reis, VP, Romano, F, Alves, M, Freitas, TT, and McGuigan, M. Transference effect of short-term optimum power load training on the punching impact of elite boxers. J Strength Cond Res 35(9): 2373–2378, 2021—This study examined the changes in bench press (BP), jump squat (JS), and half-squat (HS) power outputs induced by a short-term (1 week) training scheme based on the optimum power load (OPL) applied to national boxing athletes and measured the transference effect coefficient (TEC) of these exercises on punching impact. Eight elite boxing athletes from the Brazilian National team participated in this study. Athletes were tested before and after 3 power-oriented training sessions performed at the OPL. The physical assessments comprised punching impact measures (jabs and crosses) at fixed and self-selected distances, and bar-power output in BP, HS, and JS exercises. Magnitude-based differences were used to compare pre-training and post-training sessions. Transference effect coefficient was calculated as the ratio between the result gain in the “untrained exercises” (punching impact in jabs and crosses) and “trained exercises” (HS, JS, and BP), for variables presenting an effect size of at least 0.2. The OPL training elicited meaningful increases in the punching impact forces (∼8%) and in both JS and HS power outputs (∼12 and ∼14%, respectively), but not in BP power output. There was an effective transference (TEC = ∼0.80) of JS and HS performance gains to punching impact force, suggesting that increases in lower-limb power can be directly transferred to punching impact. These results provide coaches and practitioners with valuable information about how to rapidly and effectively increase the punching impact force of elite amateur boxers.
Sexual Education and Women Empowerment in Health: A Review of the Literature
Authors: Mirzaii Najmabadi Khadigeh , Sharifi Farangis
Published: April 2019

Objectives: Women constitute almost 50% of the world population and play a number of roles in the community. The present study aimed to assess the relationship between sex education and women empowerment in health. Methods: Based on the aim of the study, the data were obtained reviewing the related literature on electronic and non-electronic websites and using equivalent keywords published until the last week of February 2018. In addition, mesh terms and key words were included in this research. Inclusion criteria were articles published from 2005 to February 2018. All the observation or interventional studies including ten articles which met the search criteria were studied. Results: The results revealed that sex education has different effects on sexual attitudes or activities of women. Further, it was effective in increasing the sexual autonomy of female college students. Furthermore, health providers’ contribution may improve sexual autonomy. In the current study, sex education programs were effective at increasing HIV/AIDS ( Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) knowledge and condom use, reducing the risk of unprotected intercourse and sexually transmitted infections (STIs), as well as unplanned pregnancy and abortion. Finally, abstinence-plus sex education programs increased health knowledge while they reduced risky sexual behaviors. Conclusions: In general, sex education is a critical method of women empowerment in health through increasing their health knowledge and related behaviors. Therefore, a compilation program of sex education is more useful. Accordingly, seeking to place sex training in the educational curriculum in accordance with the culture of the countries is a necessity.
Fixed Versus Flexible Antagonist Protocol in Reduced Ovarian Reserve Patients: A Historical Cohort Study
Authors: Akbari Asbagh Firouzeh , Dehbashi Zahra , Moosazadeh Mahmood , Pourmand Amirhossien , Ebrahimi Mahbod , Pourmand Naghmeh , Akbari Asbagh Parvin
Published: April 2019

Objectives: The antagonist of gonadotropin-releasing hormone is proven to be effective and safe in preventing a surge in luteinizing hormone (LH) during in vitro fertilization (IVF) cycles. In addition, the differentiation of GnRH antagonist protocols is in timing the initiation of the GnRH antagonist. The present study aimed to compare fixed versus flexible antagonist regimens in patients with reduced ovarian reserve in order to identify a better regimen for these patients. Materials and Methods: This study was of a historical cohort type. Totally, 129 patient files were investigated including 48 versus 66 files related to fixed or flexible protocols, respectively. The mean of age, body mass index (BMI), follicle stimulating hormone (FSH), and anti-Mullerian hormone (AMH), as well as the mean dose of gonadotropin, the mean length of IVF/ICSI cycles, and the mean counts of oocytes and embryos with grading including good, fair, and poor were compared between the 2 groups. Results: The total and mean consumption of gonadotropin dose (recombinant FSH) in the flexible and fixed groups were significantly different (P=0.05). However, the mean antagonist (cetrotide) doses in the fixed and flexible groups were not significantly different while it was lower in the flexible group (P = 0.50). Finally, the duration of gonadotropin consumption in IVF/ICSI period was not significantly different between the two groups. Conclusions: In general, the fixed protocol is recommended in patients with reduced ovarian reserve since it is simple to use and more cost effective compared to the flexible protocol.
The Association Between Menopausal Symptoms and General Health Among Iranian Women With Menopause: A Cross-Sectional Study
Authors: Sharifi Nasibeh , Najar Shahnaz , Rezaii Nazanin , Jalili Lida , Yazdizadeh Hamideh , Yaralizadeh Masumeh
Published: April 2019

Objectives: Health promotion leads to a higher quality of life among women. The present study aimed to investigate the relationship between menopausal symptoms and general health among women with menopause. Materials and Methods: In this cross-sectional, 600 postpartum women in Ahvaz, Iran were selected and recruited using the randomized cluster sampling method during 2013-2014. The data were collected by the women’s demographic characteristics instrument, as well as the Goldenberg’s and menopausal symptoms questionnaires. In addition, descriptive statistics and logistic regression were employed for data analysis by the SPSS software, version 19. The statistical tests were performed at 95% confidence interval. Results: As regards the menopausal symptoms, sleep disorders (39%), myalgia (42.7%), and hot flashes (32.5%) were reported as moderate, severe, and very severe, respectively. Further, 50.2% of the participants had impaired general health. Finally, job, hot flashes, sleep disorders, myalgia, depression, and aggressiveness were associated with general health (P<0.05). Conclusions: In general, there is a need to improve public health and reduce menopausal symptoms among postmenopausal women since menopause is changed to a crisis in a woman’s life.
Enhancing Descriptive Writing Achievement of Tenth Graders by Using Internet Meme Picture
Authors: Inderawati Rita , Ariani Dea , Hambali Muslih
Published: April 2019

ABSTRACTThe objectives of this study were to find out whether or not: (1) there was a significant difference in Descriptive Writing achievement after the tenth grade students of SMA Negeri 1 Indralaya Utara were taught by using internet meme picture and (2) there was a significant difference in Descriptive Writing achievement between the students who were taught by using internet meme pictures and those who were not. The samples of this study were X MIPA 1 and X MIPA 2 with the total number of 64 students. To collect the data, each group was given pre-test and post-test of writing. The data were analyzed by using Paired Sample t-test and Independent Sample t-test in SPSS version 22. The results from Paired Sample t-test showed that there was a significant difference in Descriptive Writing achievement before and after the tenth-grade students of SMA Negeri 1 Indralaya Utara were taught by using Internet Meme Picture. The result from Independent Sample t-test of the post-test in both experimental and control groups showed that there was a significant difference in Descriptive Writing achievement between the students who were taught by using Internet Meme Picture and those who were not as the r-value both of Paired Sample t-test and Independent Sample t-test results were lower than 0.05 (0.000 < .05).  ABSTRAKTujuan penelitian ini adalah untuk mengetahui apakah: (1) ada perbedaan yang signifikan dalam menulis deskriptif setelah siswa kelas sepuluh SMA Negeri 1 Indralaya Utara diajarkan dengan menggunakan Internet Meme Picture dan (2) ada perbedaan yang signifikan dalam penulisan deskriptif antara siswa yang diajar dengan menggunakan Internet Meme Picture dengan mereka yang tidak. Sampel penelitian ini adalah kelas X MIPA 1 dan X MIPA 2 dengan jumlah total 64 siswa. Untuk mengumpulkan data, setiap kelompok diberikan pre-test dan post-test penulisan. Data dianalisis dengan menggunakan Paired Sample t-test dan Independent Sample t-test dengan SPSS versi 22. Hasil dari Paired Sample t-test menunjukkan bahwa ada perbedaan yang signifikan dalam penulisan deskriptif sebelum dan sesudah siswa kelas X SMA Negeri 1 Indralaya Utara diajarkan dengan menggunakan Internet Meme Picture. Hasil Independent Sample t-test dari post-test di kedua kelompok yaitu eksperimen dan kontrol menunjukkan bahwa ada perbedaan yang signifikan dalam prestasi penulisan deskriptif antara siswa yang diajar dengan menggunakan Internet Meme Picture dan dengan mereka yang tidak. Nilai kedua t-test yaitu hasil Paired Sample t-test dan hasil Independent t-test lebih rendah dari 0,05 (0,000 <0,05).How to Cite: Inderawati, R., Ariani, D. N., Hambali, M. (2018). Enhancing Descriptive Writing Achievement of Tenth Graders by Using Internet Meme Picture. IJEE (Indonesian Journal of English Education), 5(2), 176-190. doi:10.15408/ijee.v5i2.7666. Inserted: -