bluuebunny/crossref_metadata_2025 huggingface dataset:
The Emerging role of HDACs: Pathology and Therapeutic targets in Diabetes Mellitus
Authors: Dewanjee Saikat , Vallamkondu Jayalakshmi , Chakraborty Pratik Chakraborty , Kalra Rajkumarsingh , Gangopadhyay Moumita , Sahu Ranabir , Medala Vijaykrishna , John Albin , Reddy P. Hemachandra , Kandimalla Ramesh
Published: April 2021

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can induce several vascular complications that were referred to be the major cause of morbidity and mortality in DM. Although several therapeutic targets have been identified and accessed clinically, the imminent risk of DM and its prevalence are still ascending. Substantial pieces of evidence revealed that histone deacetylase (HDAC) isoforms can regulate various molecular activities in DM via epigenetic and post-translational regulation of several transcription factors. To date, 18 HDAC isoforms have been identified in mammals that were categorized into 4 different classes. Classes I, II, and IV are regarded as classical HDACs, which operate through a Zn-based mechanism. In contrast, class III HDACs or Sirtuins depend on nicotinamide adenine dinucleotide (NAD+) for their molecular activity. Functionally, most of the HDAC isoforms can regulate β cell fate, insulin release, insulin expression and signaling, and glucose metabolism. Moreover, the roles of HDAC members have been implicated in the regulation of oxidative stress, inflammation, apoptosis, fibrosis, and other pathological events, which substantially contribute to diabetes-related vascular dysfunctions. Therefore, HDACs could serve as the potential therapeutic target in DM towards developing novel intervention strategies. This review sheds light on the emerging role of HDACs/isoforms in diabetic pathophysiology and emphasized the scope of their targeting in DM for constituting the novel interventional strategies for metabolic disorders/complications.
Pitfalls and Caveats in Applying Immunostaining to Histopathological Diagnosis
Authors: Tsutsumi Yutaka
Published: April 2021

Immunostaining is an essential histochemical technique for analyzing pathogenesis and making a histopathological diagnosis. The needs are prompted by technical development and refinement, commercial availability of a variety of antibodies, deepened knowledge of immunohistochemical markers, accelerated analysis of morphofunctional correlations, progress in molecular target therapy, and the expectation of advanced histopathological diagnosis. However, immunostaining does have various pitfalls and caveats. We should learn from mistakes and failures, as well as from false positivity and false negativity. The present review article describes various devices, technical hints and trouble-shooting guides to keep in mind in performing immunostaining.
Monitoring of Vibrations in Free-Form Surface Processing Using Ball Nose End Mill Tools with Wireless Tool Holder Systems
Authors: Yamamoto Takamasa , Matsuda Ryo , Shindou Masatoshi , Hirogaki Toshiki , Aoyama Eiichi ,   Research and Development Group, Yamamoto Metal Technos Co., Ltd. 4-7 Setoguchi 2-chome, Hirano, Osaka 547-0034, Japan,   Department of Mechanical Engineering, Doshisha University, Kyotanabe, Japan
Published: April 2021

Monitoring technologies have attracted attention in the factory automation fields that rely on the Internet of Things (IoT). However, it is difficult to monitor the process information from a round machining tool during rotating operations. Therefore, we developed a novel tool holder equipped with a wireless communication function to monitor tool vibrations. In the present study, we attempt to measure the tool holder vibrations during ball nose end milling processes using the servo driving information for different machine tools. We demonstrate that, using the developed tool holder with a wireless system, it is feasible to improve the machined free form surface by considering the servo driving information.
Effect of Strain-Rate on Forming Limit Strain of Aluminum Alloy and Mild Steel Sheets Under Strain Path Change
Authors: Yamashita Minoru , Komuro Shohei , Nikawa Makoto ,   Department of Mechanical Engineering, Faculty of Engineering, Gifu University 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan,   Department of Materials Science and Processing, Graduate School of Natural Science and Technology, Gifu University, Gifu, Japan
Published: April 2021

The aim of this study is to show the effect of the strain-rate on the forming limit strain of an aluminum alloy A5052 sheet and a mild steel sheet SPCC. Biaxial stretching test was carried out. The prescribed strain path was linear path or that with directional change in straining. The sheet was pre-strained by uniaxial tension in the latter path. The deformation speed was set to be quasi-static or high speed whose strain-rate was about 300 /s using the dedicated high speed stretching device. The forming limit strain of the A5052 sheet for the linear strain path was larger in the high speed stretching than that under the quasi-static condition. For the case with strain path change the forming limit strain was further large. This may be due to the softening phenomenon which occurs by aging treatment, because the stretching experiment was conducted about two weeks after the pre-straining operation. On the other hand, the forming limit strain of the SPCC under the high speed condition was smaller than that under the quasi-static condition in the linear strain path. This is attributed to the decreased strain hardening exponent when the strain-rate increases. Further, in the equi-biaxial stretching of the pre-strained specimen, large difference of the forming limit strain between the deformation speeds was found. It is concluded that A5052 aluminum alloy sheet has a good adaptability to high speed forming, on the other hand, attention should be paid in increasing the forming speed of SPCC.
Evaluation of Residual Stress in Die Castings of Al-Si-Cu Alloy Considering Material Composition Change in Thickness Direction
Authors: Nikawa Makoto , Sasai Daichi , Mizutani Yoshiki , Yamashita Minoru ,   Department of Mechanical Engineering, Faculty of Engineering, Gifu University 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan,   Department of Materials Science and Processing, Gifu University, Gifu, Japan,   Gifu Prefectural Industrial Technology Center, Gifu, Japan
Published: April 2021

This study investigated a method for accurately predicting the residual stress in die castings manufactured using aluminum alloy. To account for the mechanical properties caused by the material composition differences that occur in the thickness direction of the die castings, a model split in the thickness direction was used in the simulation model. Norton’s law was applied to the constitutive equation of the material, and the stress relaxation phenomenon was examined. The composition of Al-Si-Cu alloy (JIS-ADC12) die castings in the thickness direction were analyzed using scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM-EDS), and differences in composition were confirmed. As a result of calculating the residual stress using the simulation, it was possible to calculate the residual stress that could not be reproduced by the simulation model of uniform composition. This suggested that the difference in mechanical properties of die castings in the micro-region influences the residual stress.
Student’s strategies in online autonomous English language learning
Authors: Inayati Nina , Rachmadhani Rachyani Ayulis , Utami Berliana Nurmustika
Published: April 2021

This study investigates the integration of online technology by English language learners, especially those done in autonomous learning. To be more specific, this study aims to discover how systematic is students’ strategies in online autonomous language learning and the supports they expect from the educational institutions and teachers/lecturers in terms of conducting effective online autonomous learning. This study mainly employs survey design which is supported by interview. The population of the study was the undergraduate students of English Language Education Department in a private university in Malang, East Java, Indonesia. The findings suggest that learners were less systematic in their strategy use when conducting autonomous language learning. They showed lack of long term goal setting and reported difficulty in evaluation, and mostly resort to short term planning, resource finding and execution of learning. For the reasons, avoidance of classroom-like feeling and not knowing how to evaluate was repeatedly noted. Further, they also reported high expectation of teachers and institutions’ support and assistance in conducting autonomous language learning. The current study and some previous studies in the area have noted that learners tend to consider goal setting and evaluation as teachers’ areas, influenced by the fixed curriculum imposed in schools and university. As such, some flexibility in curriculum enactment is proposed and stronger intervention by teachers and institutions to support learners’ autonomy are proposed.
FRASA PREPOSISIONAL BERMAKNA TEMPAT DALAM KALIMAT BAHASA BUGIS: SUATU KAJIAN STRUKTUR DAN SEMATIK
Authors: Haedariah Haedariah
Published: April 2021

The research entitled "Prepositional Phrases Meaningful Places in Bugis Sentences" describe prepositions in Bugis in terms of form, meaning and category. The method used in this research is descriptive distribution. The main data of this research comes from written language, while the oral and artificial data are used as supporting data. The research aims to (1) describe the prepositions of the meaning of places in Buginese, (2) describe the linguistic elements associated with Bugis language prepositions, (3) describe the functions occupied by prepositional phrases meaning place in Bugis language, and (4) describe the meaning the place contained in the prepositions in the Buginese language. The results of this study. Keywords: Prasa, Preposition, Linguistic Elements, Syntax Function
PENGGUNAAN POLA KALIMAT KAGIRI DAN KAGIRI DA DALAM BAHASA JEPANG (ANALISIS STRUKTUR DAN MAKNA)
Authors: Putri Mellati Riandi , Wagiati Wagiati
Published: April 2021

The purpose of this research is to find the way of using kagiri and kagiri da as sentence patterns in Japanese. The type of this research is qualitative research with descriptive method. The data was taken from Japanese online news website, Asahi Shinbun which published on early December 2020 that contain sentences that using kagiri and kagiri da sentence pattern. There are 21 data gathered from Asahi Shinbun, and based on the part of speech that formed with kagiri and kagiri da sentence pattern, there are ten data were classified as noun, nine data were classified as verb, and 2 data classified as adjective. The kagiri sentence pattern used as conjunction when formed with noun and verd with semantic meaning as “while” with certain condition or terms, and used as suffix when formed with noun which containing number or time with semantic meaning of limitation of something. While the kagiri da sentence pattern only formed with adjectives and always in the end of the sentence with semantic meaning of describing a certain level of the speaker feelings. The kagiri sentence pattern have a lot of variations such as formed with joshi in ni kagiri pattern, ni kagitte pattern, and ni kagiru pattern. The further research through another data source such as corpus may needed to find another purpose of this sentence pattern. Keywords: syntax, semantic, verb, kagiri, kagiri da
PROMOTING GRAMMATICAL AWARENESS IN ENGLISH LANGUAGE TEACHING: ESP CONTEXT
Authors: Milawati Milawati
Published: April 2021

Recently, English Specific Purposes is taking a crutial issue to be considered. Since the implementation of ESP is apropriate to the need of its studies, the English skills which required by students is getting growth. Indeed, grammar as one of language components which supports the language skills also changing as its usage. However, the implementation of the grammar usage in ESP, is not really proper to its context. This paper presents the possibilities factors behind its unproper usage and also some activities which raises students’ grammar awarenes . By knowing more about those issue will not only help the teacher to lead the students more effectively and properly in using the grammar, but it will also provide the teacher with a means of evaluating the teaching learning process and help the teacher to produce activities that will actually motivate the students to learn. Keywords: Grammatical Awareness, ESP, English Language Teaching
MINI GROUP DISCUSSION: COOPERATIVE LEARNING IN TEACHING READING
Authors: Fajarina Maskhurin , Ma’rifatullah Sayid
Published: April 2021

The aim of the research is to determine mini-group discussion as a cooperative learning in teaching reading. In the article, the method used is quantitative and descriptive qualitative which focus on teaching reading English text of Unhasy Students non-English department. It focus on some problems, those are How the implementation of mini group discussion (mindis) in teaching reading English and How the influence of (Mindis) into students’ enhancement in reading English comprehension. The researcher used test as an instrument and interview of the students. The result of the research are Mindis is easy to teach reading English in non-English department and it has significant influence into the students’ enhancement in reading English. Keywords: mindis, teaching reading, students’ enhancement
The Aksug Porphyry Cu–Mo Ore-Magmatic System (Northeastern Tuva): Sources and Formation of Ore-Bearing Magma
Authors: Berzina A.N. , Berzina A.P. , Gimon V.O.
Published: April 2021

––Two stages are recognized in the evolution of the Aksug ore-magmatic system (OMS): (1) formation of the Aksug granitoid pluton and (2) emplacement of small ore-bearing intrusions. Intrusive bodies of the two stages are composed of rocks of the same type and bear copper mineralization: poor dispersed and large-scale veinlet-disseminated, respectively. The pluton and small intrusions are formed by gabbroid and granitoid rocks, with similar petrogeochemical characteristics of igneous rocks of the same type. The plutonic gabbroic association includes gabbro, gabbrodiorites, and pyroxene–amphibole diorites/quartz diorites. The small subvolcanic gabbroic intrusions are gabbrodiorite and diorite porphyrites. The trace element patterns of the gabbroids are similar to those of igneous rocks in subduction zones. The gabbroids are characterized by isotope parameters εNd(500) = +6.1 to +7.2 and (87Sr/86Sr)500 = 0.7022–0.7030 and model age TNd(DM) = 0.85–0.74 Ga. As follows from the geochemical parameters, the depleted mantle metasomatized by subduction fluids was the source of basaltic magma. The plutonic granitoid association includes tonalites, plagiogranites, and amphibole diorites/quartz diorites; the small subvolcanic granitoid intrusions are tonalite porphyry and quartz diorite porphyrites. The trace element patterns and Nd and Sr isotope compositions of the granitoids are much similar to those of the gabbroids. According to the geochemical parameters, tonalitic and plagiogranitic magmas formed through the melting of juvenile mafic crust, and dioritic magma resulted from the mixing of basaltic and tonalitic/plagiogranitic magmas. In the course of the OMS formation, metals and volatiles were introduced by basaltic and granitoid magmas from the metasomatized mantle and juvenile mafic crust. The compression setting during the pluton formation hampered the separation of ore-bearing fluids, which led to poor dispersed mineralization. The extension setting during the emplacement of small intrusions favored the intense separation of ore-bearing fluids. The interaction of magma and fluids of the small intrusions with rocks of the pluton was accompanied by the removal of metals from the latter and their involvement in the ore-forming process. This increased the ore potential of the magmatic system and favored the formation of rich mineralization at the final stage of its evolution.
Optimizing Laccase Production in Auricularia Cornea by Submerged Fermentation With Wheat Bran Extract: Applications in Decolorization of Malachite Green Dye
Authors: Meng Li , Bai Xiaoran , Wang Qingji , Li Xiaobo , Zhang Shaoyan , Wang Li , Wang Wei , Li Zhuang
Published: April 2021

Wheat bran extract may enhance laccase activity of Auricularia cornea in submerged fermentation. The laccase activity of A. cornea was maximal (768.78 U/mL) at 26.9 ℃, pH 5, a time point of 6 d, 22 h, and an inducer concentration of 10%. Laccase from A. cornea AC5 decolorized 83.27% of 75 mg/L malachite green within 12 h. High performance liquid chromatography (HPLC) analysis of the extracted metabolites suggested that the decolorization occurred through biodegradation. Malachite green induced cytotoxic damage including formation of a micronucleus and chromosome bridge at anaphase. Degradation products of malachite green proved to be less toxic and had negligible effects on chromosomal aberrations.
Remediation of textile industry organic dye waste by photocatalysis using eggshell impregnated ZnO/CuO nanocomposite
Authors: Gerawork Mekdes
Published: April 2021

Heterogeneous photocatalysis using nanocomposites is of great research interest in the treatment of industrial wastewater. The impregnated photocatalyst was produced by liquid state reaction of ZnO/CuO nanocomposite with extracted eggshells. The structure, functional group, metal composition, bandgap, and photocatalytic activity of the nanocomposites were characterized by using X-ray diffraction, Fourier-transform infrared spectroscopy, atomic absorption spectrometry, and UV–Vis spectroscopy, respectively, in the absence and presence of eggshells. Photocatalytic degradation activities of the nanocomposites under UV light irradiation have been tested for a real sewage sample taken from Debre Berhan Textile Industry. From the results, the optimized degradation efficiency of the dye was 97.95% with 0.4 g dose of the photocatalyst, 120 min irradiation time, 120 °C temperature, and pH of 6.7. The results revealed that eggshell impregnated nanocomposite had better catalytic activity than the naked nanocomposite. This is due to the highly porous structure of eggshell biomasses and their sorption characteristics. In conclusion, when nanocomposites are supported by eggshell biomasses, they are excellent photocatalysts and can minimize the contamination of organic dyes from textile effluents.
The use of social media in ethic digital perspective
Authors: Rawanoko Endrise Septina , Komalasari Kokom , Al-Muchtar Suwarma , Bestari Prayoga
Published: April 2021

Penggunaan media sosial pada mahasiswa menjadi salah satu gaya hidup di lingkungan Universitas Wisnuwardhana Malang. Pada era digital seperti saat ini penggunaan media sosial sering disalah gunakan bahkan menjadi ajang bully, rasis, dsb. Untuk itu penggunaan media sosial perspektif digital ethic hadir sebagai cara untuk meminimalisir kebobrokan moral anak didik di media sosial. Riset ini berfokus pada penggunaan media sosial perspektif digital ethic pada mahasiswa di Universitas Wisnuwardhana Malang. Metode penelitian ini adalah kualitatif deskriptif. Hasil dari penelitian di lapangan mengenai penggunaan media sosial dan perspektif digital ethic adalah mayoritas mahasiswa Universitas Wisnuwardhana Malang menggunakan media hanya untuk memposting foto-foto pribadi serta kegiatan yang positif. Sistem komunikasi sosial yang ada di media sosial, sama persis dengan sistem komunikasi dalam lingkungan sehari-hari. Mahasiswa Universitas Wisnuwardhana Malang mempertimbangkan dalam mengupload ataupun memposting di media sosial. ABSTRACTThe use of social media for students is one of the lifestyles in the University of Wisnuwardhana Malang. In this digital era, the use of social media is often misused. It even becomes an arena for bullying, racism, etc. For this reason, the use of social media with an ethical digital perspective is present to minimize the moral decay of students on social media. This research focuses on using social media with a digital ethics perspective on students at Wisnuwardhana University Malang. This research method is descriptive qualitative. The research results in the field regarding the use of social media and the digital ethics perspective are that many Wisnuwardhana University Malang students use the media only to post personal photos and positive activities. The social communication system in social media is precisely the same as the communication system in everyday life. Wisnuwardhana University Malang students consider uploading or posting on social media
On the Same Skywalk in a Time of Pandemic: How a vulnerable group copes with the new conditions in Hong Kong
Authors: Villani Caterina , Talamini Gianni , Hu Zhijian
Published: April 2021

The public space plays a crucial role in providing adequate infrastructure for vulnerable social groups in the context of high-density urban Asia. In this study, a well-known elevated pedestrian network in Hong Kong emerges as a revelatory case for the comparative analysis of the pattern of stationary uses before and after the COVID-19 pandemic out-break. Findings reveal a significant decrease (-20 %) in the total number of users and a shift in the pattern of activities, comprising a significant shrinkage of socially oriented uses and a vast increase of individual behaviors. This study advocates a responsive policymaking that considers the peculiar post-outbreak needs of migrant workers in Hong Kong and in high-density urban Asia
The Conservation of Old Johar Market Building
Authors: Rukayah R. Siti , Sardjono Agung Budi , Abdullah Muhammad , Etenia Annica
Published: April 2021

The conservation efforts for heritage architecture are currently trending. This paper aims to uncover the conservation of traditional markets after experiencing a fire in the Johar market, Semarang, Central Java, Indonesia. After the market was renovated, it turned out that it had not included all traders in it. Using the historical method, there is revealing that the number of traders exceeds the room's capacity. Theory discusses about the conservation approach and applied adaptive reuse theory found that the initial plan, is possible to return its function as a market by adjusting the number of traders' capacity. The advantages of traders are recommended to occupy the old square area as open spaces to be attractive for heritage tourism.
The paradox of enrichment, spatial heterogeneity, community effects and the phenomenon of apparent disappearance in the marine bacteriophage dynamics
Authors: Korobeinikov Andrei , Shchepakina Elena , Sobolev Vladimir Sobolev
Published: April 2021

In aquatic microbial systems, high magnitude variations in abundance, such as sudden blooms alternating with comparatively long periods of very low abundance ("apparent disappearance'') are relatively common. The authors suggest that, in order to occur, such variations in abundance in microbial systems and, in particular, the apparent disappearance of species do not require seasonal or periodic forcing of any kind, or external factors of any other nature, and can be caused by internal factors, and in particular by bacteria-phage interaction. Specifically, the authors suggest that the variations in abundance and the apparent disappearance phenomenon can be a result of phage infection and the lysis of infected bacteria. To illustrate this idea, the authors consider a reasonably simple mathematical model of bacteria-phage interaction based on the model suggested by Edoardo Beretta and Yang Kuang, which assumes neither periodic forcing, nor action of other external factors. The model admits a loss of stability via Andronov-Hopf bifurcation and exhibits dynamics which is able to explains the phenomenon. These properties of the model are especially distinctive for spatially non-homogeneous biosystems as well as biosystem with some sorts of cooperation or community effects.
doi:10.1017/S1446181120000085
Draping woven sheets
Authors: Howell P. D. , Ockendon H. , Ockendon J. R.
Published: April 2021

Motivated by the manufacture of carbon fibre components, this paper considers the smooth draping of loosely woven fabric over rigid obstacles, both smooth and nonsmooth. The draped fabric is modelled as the continuum limit of a Chebyshev net of two families of short rigid rods that are freely pivoted at their joints. This approach results in a system of nonlinear hyperbolic partial differential equations whose characteristics are the fibres in the fabric. The analysis of this system gives useful information about the drapability of obstacles of many shapes and also poses interesting theoretical questions concerning well-posedness, smoothness and computability of the solutions.
doi:10.1017/S144618112000019X
On existence and uniqueness of solutions to a pantograph type equation
Authors: Mohsin Muhammad , Zaidi Ali Ashher
Published: April 2021

We show existence and uniqueness of solutions to an initial boundary value problem that entails a pantograph type functional partial differential equation with two advanced nonlocal terms. The problem models cell growth and division into two daughter cells of different sizes. There is a paucity of information about the solution to the problem for an arbitrary initial cell distribution.
doi:10.1017/S144618112100002X
Procesamiento de imágenes multiespectrales captadas con drones para evaluar el índice de vegetación de diferencia normalizada en plantaciones de café variedad Castillo
Authors: Bonnaire Rivera Lou , Montoya Bonilla Bibiana , Obando-Vidal Francisco
Published: April 2021

El café es un producto importante en la economía colombiana que aporta en alto grado a los ingresos de los agricultores en el departamento de Cauca, quienes buscan aumentar su rentabilidad mediante procesos diferenciados en el cultivo y valor agregado en la cosecha. En la actualidad, el manejo agronómico se hace de manera tradicional y por plantas al azar, lo que limita la visión general del estado del lote. La agricultura de precisión es una herramienta que hace más confiable el manejo del cultivo al considerar sus diferentes características agroclimáticas. El presente estudio evidencia el uso de imágenes multiespectrales del terreno tomadas con drones para determinar de forma temprana el estado nutricional de las plantas. Como resultado, se consolidó un sistema de información que permitió el procesamiento de imágenes por medio de un algoritmo que calcula el índice de vegetación de diferencia normalizada (NDVI, por su sigla en inglés). En el cultivo de café variedad Castillo se alcanzaron valores de NDVI superiores a 0,8. Al contrastar los datos obtenidos por el dron con los datos registrados en tierra mediante un espectrómetro foliar y una prueba de Tukey (p = 0,05), se evidenciaron diferencias significativas entre los métodos de evaluación.
A decentralized Offline Patient ID Generation and Matching Algorithm: Nigeria phone number-based proposal (Preprint)
Authors: Chukwu Emeka , Ekong Iniobong , Garg Lalit
Published: April 2021

BACKGROUND

Quality of health service delivery data remains sub-optimal in many developing countries despite over a decade of progress in digitization and Health Management Information Systems (HMIS). Uniquely identifying Patients within the care continuum is the only way to guarantee better outcomes hinged on cross-institution shared health records. Many different strategies exist for uniquely identifying and tracking a patient in a health system, and they also have their trade-offs.

OBJECTIVE

This paper aims to use Nigeria, a typical low-and-middle-income country, to demonstrate how leading candidates for Patient identification fit in the digital Patient ID desirable attributes framework. This paper also designed and proposed an offline decentralized Patient ID generation and matching model to address network reliability challenges.

METHODS

We surveyed and present the leading candidates for Patient ID in Nigeria. We then designed a phone-based Patient matching model starting from current Nigeria's Federal Capital Territory administration model.

RESULTS

We show that no current Patient ID strategy simultaneously meets the six attributes of uniqueness, unchanging, uncontroversial, inexpensive, ubiquitous, and uncomplicated. We surveyed patient identification schemes and presented algorithms for universal-offline Patient ID generation and matching models.

CONCLUSIONS

Our model shows a prototype for generating and validating a universally unique Patient ID given a set of Patient characteristics without a central authority. This model can help fast-track implementing a Master Patient Index (MPI) in Low and Middle-Income Countries.

CLINICALTRIAL
A Diagnostic Pitfall of a Sternal Mass
Authors: ABID Walid , HENTATI Abdessalem , HLIMA Ghassen BEN , REBAI Mohamed , LASMAR Ahmed , GOUIAA Naourez , FRIKHA Imed
Published: April 2021

The sternum is an exceptional localization for Diffuse Large B Cells
Lymphoma. A Case of a man with a sternal mass that mimics a sarcoma on
the CT scan. Needle biopsy was not contributive. Surgical resection was
indicated because of a local progression. Histopathological examination
concluded to a primary DLBCL
Recurrent Kaposi Sarcoma of the Ear in an HIV-negative patient: A Case report with review of the literature. Is ear a predilection site for Kaposi sarcoma in HIV-negatives?
Authors: Etesami ifa , Kalantari Yasamin , Ghanadan Alireza , Rezayat Azadeh
Published: April 2021

Kaposi sarcoma (KS) is an angioproliferative disorder. While KS of the
head and neck is common in HIV-positives, it’s rare in HIV-negatives.
Our case and the past 24 reported cases of ear KS reviewed here,
highlight the importance of considering KS in the differential diagnosis
of ear lesions in HIV-negatives.
Awake Craniotomy
Authors: McNicholl Dennis J.
Published: April 2021

Prior to the advent of anesthesia, performing surgical procedures on patients in the awake state was the order of the day. In modern times, especially with the continued advancement and safety of anesthesia, such a practice of performing surgery on a patient in the awake state might appear unnecessary, and perhaps even medieval. However, this practice still does intentionally occur for a subset of neurosurgery patients. This unique dimension of the procedure places special demands on the anesthesiologist’s knowledge base, skill and training in order to produce a successful patient outcome. This chapter delves into salient aspects of patient selection, operating room setup, monitoring and communication considerations, pharmacologic regimens, regional anesthetic options and a thorough list of complications for which to be prepared.
This review contains 5 figures, 5 tables, and 69 references.
Keywords: awake craniotomy, functional neurosurgery, eloquent cortex, awake-asleep-awake, electrocorticography, epilepsy, deep brain stimulator, dexmedetomidine, intraoperative seizure
IDENTIFIKASI RHODAMIN B PADA SAGU MUTIARA DI PASAR INDUK KOTA BANDUNG TAHUN 2019
Authors: Widiantara Tantan , Hasnelly
Published: April 2021

Sagu mutiara merupakan hasil olahan pati sagu yang berbentuk butiran(bulat-bulat) dengan warna merah, putih atau hijau. Warna pada sagu mutiara yang umum dijual tersebut sering kali terang dan mencurigakan. Penggunaan bahan tambahan pangan berbahaya masih marak terjadi karena ketidaktahuan masyarakat terhadap hal ini, terutama dalam hal penggunaan zat pewarna sintetik berbahaya rhodamin B, sehingga tujuan penelitian ini adalah untuk mengetahui ada atau tidaknya penambahan rhodamin B pada sagu mutiara di Pasar Induk Kota Bandung dan untuk mengetahui jumlah kontaminasi rhodamin B pada sagu mutiara yang dijual di Pasar Induk Kota Bandung. Pasar Induk dipilih sebagai tempat penelitian karena merupakan pasar terbesar yang biasanya menyalurkan berbagai kebutuhan kepada pasar lain disekitarnya. Metode penelitian yang digunakan adalah metode purposive sampling dengan mengambil seluruh populasi untuk dijadikan sampel sehingga menghasilkan 13 sampel terpilih dari 12 pedagang. Sebanyak 4 sampel didapatkan dari Pasar Induk Gede Bage dan 9 sampel dari 12 pedagang didapatkan dari Pasar Induk Caringin. Analisis kualitatif zat pewarna dilakukan dengan metode spot test. Sedangkan analisis kuantitatif dilakukan dengan metode spektrofotometri. Hasil penelitian secara kualitatif menunjukkan bahwa sagu mutiara tidak mengandung rhodamin B, namun teridentifikasi pewarna jenis lain yaitu crystal panceau, amaranth dan azorubin A, sehingga tidak dilakukan analisis lebih lanjut secara kuantitatif. Crystal panceau dan Amaranth merupakan bahan pewarna yang dilarang sedangkan azorubin A atau karmoisin merupakan bahan pewarna yang diperbolehkan dalam batas tertentu. Sampel yang teridentifikasi sebagai produk yang mengandung pewarna crystal panceau sebanyak 10 sampel, sedangkan sampel yang teridentifikasi mengandung pewarna amaranth dan azorubin A masing-masing sebanyak satu sampel, lalu satu sampel lainnya tidak teridentifikasi jenis pewarnanya
PENGARUH KONSENTRASI AMPAS KECAP DAN KONSENTRASI WORTEL (Daucus carota) TERHADAP KARAKTERISTIK NUGGET NABATI
Authors: Ikrawan Yusep , Nurminabari Ina Siti
Published: April 2021

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh interaksi konsentrasi ampas kecap dan konsentrasi wortel terhadap karakteristik nugget nabati. Rancangan percobaan yang digunakan pada penelitian ini adalah pola faktorial (3x3) dalam Rancangan Acak Kelompok (RAK) dengan 3 kali ulangan. Rancangan perlakuan yang dilakukan pada penelitian ini terdiri dari dua faktor yaitu konsentrasi ampas kecap (H) yang terdiri dari 3 taraf yaitu h1 (45%), h2 (50%), dan h3 (55%) dan konsentrasi wortel (W) yang terdiri dari 3 taraf yaitu w1 (5%), w2 (10%), dan w3 (15%). Respon organoleptik meliputi kenampakan, tekstur, aroma, dan rasa. Respon kimia meliputi kadar protein, kadar serat kasar, kadar air, dan kadar lemak. Hasil penelitian menunjukkan Konsentrasi ampas kecap (H) berpengaruh terhadap kadar air, protein, serat kasar, lemak, kenampakan, aroma, rasa, dan tekstur. Konsentrasi wortel (W) berpengaruh terhadap serat kasar, kadar air, tekstur, rasa dan kenampakan tetapi tidak berpengaruh terhadap protein, lemak, dan aroma. Interaksi konsentrasi ampas kecap (H) dan konsentrasi wortel (W) berpengaruh terhadap kenampakan dan rasa tetapi tidak berpengaruh terhadap kadar air, protein, serat kasar, lemak, aroma, dan tekstur.
Determination of Pitavastatin Calcium by Analytical Spectrophotometry
Authors: Antakli Saad , Nejem Leon , Kullah Ahmad
Published: April 2021

Simple and rapid spectrophotometric method for the quantitative analysis of Pitavastatin calcium (PTV) in raw material and tablets pharmaceutical formulation has been described. The method is based on the formation of yellow ion-pair complex between Pitavastatin calcium and Bromocresol purple (BCP) in chloroform medium.
Different parameters affecting the reaction such as: effect of solvents, stability, reagent concentration, correlation ratio, etc. were optimized. The formed complex was quantified spectrophotometrically at absorption maximum 405 nm. Linearity range was 2.20 - 35.23 µg/mL, regression analysis showed a good correlation coefficient R2 = 0.9991. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.367 µg/mL and 1.112 µg/mL respectively. The average percent recovery was found to be (100.62 – 101.14) % for Pitavastatin Calcium. This study was applied on Syrian pharmaceutical trademark: (PAVACRIUM 4 & Londalop). The method was successfully applied for the determination of Pitavastatin calcium in tablets pharmaceutical formulation.
The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.
Organizational Learning and Innovation in the Tourism Industry as a Basis for Creating Value for Tourists
Authors: Kostadinović Ivana , Stanković Sunčica
Published: April 2021

Organizational learning, innovation and creating value for tourists are the main issues in a successful tourism research. From that point of view, the aim of the study is to examine the relationship between the variables included in the research: organizational learning, innovation and creating value for tourists. The tested conceptual model didn’t fit well, so it was corrected based on the recommendations for a possible revision of the model. The analysis results indicated a significant impact of organizational learning on innovation and on creating value for tourists. Innovation, also, has a significant impact on creating value for tourists. Furthermore, the results indicated that innovation established the relationship between organizational learning and creating value for tourists. These results show the importance of organizational learning and innovation to improve creating value for tourists.
Workout Pacing Predictors of Crossfit® Open Performance: A Pilot Study
Authors: Mangine Gerald , Feito Yuri , Tankersley Joy , McDougle Jacob , Kliszczewicz Brian
Published: April 2021

To observe workout repetition and rest interval pacing strategies and determine which best predicted performance during the 2016 CrossFit® Open, five male (34.4 ± 3.8 years, 176 ± 5 cm, 80.3 ± 9.7 kg) and six female (35.2 ± 6.3 years, 158 ± 7 cm, 75.9 ± 19.3 kg) recreational competitors were recruited for this observational, pilot study. Exercise, round, and rest time were quantified via a stopwatch for all competitors on their first attempt of each of the five workouts. Subsequently, pacing was calculated as a repetition rate (repetitions·s-1) to determine the fastest, slowest, and average rate for each exercise, round, and rest interval, as well as how these changed (i.e., slope, Δ rate / round) across each workout. Spearman’s rank correlation coefficients indicated that several pacing variables were significantly (p < 0.05) related to performance on each workout. However, stepwise regression analysis indicated that the average round rate best predicted (p < 0.001) performance on the first (R2 = 0.89), second (R2 = 0.99), and fifth (R2 = 0.94) workouts, while the competitors’ rate on their slowest round best predicted workout three performance (R2 = 0.94, p < 0.001). The wall ball completion rate (R2 = 0.89, p = 0.002) was the best predictor of workout four performance, which was improved by 9.8% with the inclusion of the deadlift completion rate. These data suggest that when CrossFit® Open workouts consist of multiple rounds, competitors should employ a fast and sustainable pace to improve performance. Otherwise, focusing on one or two key exercises may be the best approach.
SARS-CoV-2: A critical review of preventive and control measures in the context of the virus’ characteristics
Authors: Alič Manca , Ovca Andrej
Published: April 2021

The year 2020 has been marked by the novel coronavirus, named Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), which causes coronavirus disease COVID-19. The World Health Organization (WHO) declared a global pandemic on the 11th of March 2020 due to the spread of this very contagious virus throughout the world. Since the outbreak, we have gained many insights about the virus, its presence and persistence in the environment and its possible and most common transmission routes. Such knowledge about the virus is invaluable for establishing effective preventive and control measures (also referred to as Non-Pharmaceutical Interventions (NPIs)) that have become a key to tackling this pandemic in the absence of a SARS-CoV-2 vaccine. In this review, we discuss five main groups of NPIs: 1) ventilation, 2) cleaning and disinfection, 3) hand hygiene, 4) physical distancing, and 5) protective masks. We explore their shortcomings and potential negative consequences that might occur as unwanted side effects.
Digital Inequality Through the Lens of Self-Disclosure
Authors: Lee Jooyoung , Rajtmajer Sarah , Srivatsavaya Eesha , Wilson Shomir
Published: April 2021

Recent work has brought to light disparities in privacy-related concerns based on socioeconomic status, race and ethnicity. This paper examines relationships between U.S. based Twitter users’ socio-demographic characteristics and their privacy behaviors. Income, gender, age, race/ethnicity, education level and occupation are correlated with stated and observed privacy preferences of 110 active Twitter users. Contrary to our expectations, analyses suggest that neither socioeconomic status (SES) nor demographics is a significant predictor of the use of account security features. We do find that gender and education predict rate of self-disclosure, or voluntary sharing of personal information. We explore variability in the types of information disclosed amongst socio-demographic groups. Exploratory findings indicate that: 1) participants shared less personal information than they recall having shared in exit surveys; 2) there is no strong correlation between people’s stated attitudes and their observed behaviors.
Pemahaman Petani Tentang Budidaya Kopi Arabika dan Pengaruhnya Terhadap Produktivitas Hasil Panen
Authors: Suara Komang Agus , Widia I Wayan , Gunadnya Ida Bagus Putu
Published: April 2021

Tujuan penelitian ini adalah untuk mengetahui tingkat pemahaman petani terhadap budidaya kopi dan pengaruhnya terhadap produktivitas. Aspek budidaya yang diamati meliputi persiapan lahan, pengatur intensitas cahaya, teknik tanam, pemuliaan tanaman, aplikasi pupuk, pengendalian hama tanaman, peremajaan tanaman dan aspek pemanenan kopi. Penelitian ini melibatkan 45 responden yang dipilih dengan menggunakan simple random sampling dari petani anggota kopi MPIG Kintamani Bali. Hasil wawancara indikator dari variabel penelitian nilai tertinggi diperoleh peremajaan tanaman dan panen kopi terendah. Hasil analisis data dengan Confirmatory Factor Analysis (CFA) dan Multiple Regression Analysis (MRA) menunjukkan bahwa ada tiga faktor budidaya yang relevan berkontribusi terhadap pencapaian produktivitas tanaman, yaitu persiapan lahan, teknik penanaman dan peremajaan tanaman. Teknik persiapan lahan dan penanaman memberikan efek positif pada produktivitas kopi arabika tetapi, peremajaan tanaman memberikan efek negatif. Teknik penanaman memiliki pengaruh paling dominan terhadap produktivitas tanaman kopi arabika. Diharapkan bahwa produksi panen kopi arabika di Bali (0,5 ton / Ha) kopi dapat ditingkatkan produksi kopi nasional.

The aims of this study were to determine level of understanding of farmers on coffee cultivation and its effect on productivity. Observed cultivation aspect include land preparation, light intensity regulator, planting techniques, plant breeding, fertilizer application, plant pest control, plant rejuvenation and coffee harvesting aspect. This research involved 45 respondents selected by using simple random sampling from coffee member farmers of MPIG Kintamani Bali. The results of the indicator interviews of the highest value research variables obtained plant rejuvenation and lowest coffee harvest. The results of data analysis with Confirmatory Factor Analysis (CFA) and Multiple Regression Analysis (MRA) showed that there were three relevant cultivation factors contributing to the achievement of crop productivity, namely land preparation, planting techniques and plant rejuvenation. Land preparation and planting techniques gave a positive effect on productivity of arabica coffee but, plant rejuvenation gave negatively effect. Planting techniques have the most dominant influence on the productivity of arabica coffee crops. It was expected that the production of arabica coffee harvest in Bali (0.5 ton / Ha) of coffee could be improved the national coffee production.
Peningkatan Gelombang Elektromagnetik Menurunkan Laju Perkecambahan Padi Beras Merah Cenana Jatiluwih (Oryza Sativa Var Barac Cenana)
Authors: Nugraha Viqtor Arya , Wijaya I Made Anom S. , Widia I Wayan
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pemaparan medan elektromagnetik terhadap padi varietas lokal serta mengetahui medan elektromagnetik dan waktu perendaman  yang tepat sehingga menghasilkan perkecambahan padi varietas lokal yang terbaik. Rancangan percobaan yang digunakan adalah Rancangan faktorial yang terdiri dari dua faktor. Faktor yang pertama yaitu kuat medan elektromagnetik dari 0 mT, 2 mT, 3 mT dan 4 mT, sedangkan faktor kedua yaitu lama perendaman terdiri dari 48, 64,dan 96 jam. Data yang diperoleh dianalisis dengan sidik ragam, kemudian dilanjutkan dengan uji duncan apabila perlakuan berpengaruh nyata. Hasil penelitian menunjukkan bahwa semakin kuat paparan elektromagnetik dengan tegangan tertentu mengakibatkan adanya penurunan terhadap persentase perkecambahan benih padi, sedangkan untuk perlakuan perendaman, semakin lama perendaman benih menghasilkan peningkatan persentase perkecambahan padi. Perkecambahan padi terbaik dihasilkan pada pemaparan medan elektromagnetik tegangan 2 mT dengan lama perendaman 96 jam.

This study aims to find out the modeling of electromagnetic fields against local rice varieties and to determine the electromagnetic field and the proper immersion time to produce the best rice germination. The experimental experiment used is a factorial circuit consisting of two factors. The first factor is the strength of the electromagnetic field of 0 mT, 2 mT, 3 mT and 4 mT, while the second factor is the duration of immersion consisting of 48, 64, and 96 hours. The data obtained were analyzed by verbal examination, then continued with duncan test if treatment had real effect. The results showed that the stronger electromagnetic exposure with certain voltage resulted in a decrease in the percentage of seed germination of local varieties of rice while for the immersion treatment, the longer the seed immersion resulted in increased percentage of germination of local varieties of rice. The best germination was produced at exposure of 2 mT voltage electromagnetic field with 96 hours of immersion time for red rice varieties.
Perencanaan Sistem Kelistrikan PLTMH Banjar Dinas Mekar Sari
Authors: Yanto I Putu Eka April , Giriantari I. A. Dwi , Ariastina W. G.
Published: April 2021

Intisari— Artikel ini mengemukakan tentang desain ulang Pembangkit Listrik Tenaga Mikrohidro (PLTMH) di Banjar Dinas Mekar Sari, Desa Panji, Kecamatan Sukasada, Kabupaten Buleleng, Bali. PLTMH tersebut telah beroperasi sejak tahun 1980, dengan memanfaatkan aliran air Sungai Tukad Pasut. Investigasi awal menunjukkan adanya penurunan kapasitas produksi PLTMH karena kurangnya perawatan. Selain itu, desain awal PLTMH tersebut belum mengadopsi sistem kontrol yang modern, sehingga mengakibatkan produksi listrik yang tidak efisien. Rancangan baru untuk PLTMH di Banjar Dinas Mekar Sari menggunakan turbin crossflow untuk mengakomodasi laju aliran air 1,32 m3/detik dan dengan tinggi head efektif 16 m. Energi mekanik turbin dikopel ke generator melalui sistem kopel belt dengan panjang sabuk 3099 mm. Diameter pulley adalah 750 mm untuk sisi turbin, dan 149 mm untuk sisi generator. Kapasitas generator adalah 185 kVA, 50 Hz, 230/400 V, 1500 rpm, dan dengan efisiensi 94%. Electronic Load Controller memiliki kapasitas 180 kW, dengan 6 ballast load 30 kW. Sambungan dari generator ke transformator menggunakan kabel bawah tanah NYFGbY 4 × 95 mm2, dengan panjang 69 m. Transformator berjenis step-up/step-down dengan kapasitas 250 kVA.