bluuebunny/crossref_metadata_2025 huggingface dataset:
Can HRV help screening mental illness?: Comparison with psychiatrist's diagnosis (Preprint)
Authors: Park Junhyo , Kim Kyeong min , Kim Jaejin , Kim Young-Joo , Kim Jinwoo
Published: November 2023

BACKGROUND

Clinical scales have been mainly used as tools for screening mental illnesses. However, there are limitations that the clinical scale is less accurate than the diagnosis of a psychiatrist and depends on the subjectivity of the respondent. To complement limitations from clinical scale, Heart Rate Variability (HRV) can be used, as it is reported from studies that HRV and mental illness are correlated. However, studies related to screening mental illness based on biomarkers are insufficient, and there are no studies which compared biomarker-based screening with the diagnosis of a psychiatrist.

OBJECTIVE

Comparing sensitivity and specificity of three different types of screening methods such as clinical scale only, HRV only, and combining clinical scale and HRV with psychiatrist’s diagnosis.

METHODS

The study was conducted for depressive disorder, anxiety, and insomnia, and recruited 85 patients’ group and 30 normal control group. First, psychiatrist diagnose whether the subject is mentally ill or not. Second, subjects are introduced to use mobile application which provides both HRV measurement and clinical scale.

RESULTS

The use of clinical scale and HRV together brings mental illness screening closer to the diagnosis of a psychiatrist. Specifically, including HRV in the mental illness screening increased the sensitivity of depressive disorder and anxiety by 5% respectively and increased by 4% for insomnia.

CONCLUSIONS

Sum of normalized values of HRV factors such as SDNN, LF, HF, and LF/HF Ratio and proper thresholds that classifies mental illness can increase sensitivity of clinical scale based mental illness screening. However, finding optimal threshold is required.
The Allergenicity Potential of Edible Freshwater Fish
Authors: Atika Hanum Falihah  , Muhammad Novrizal Abdi Sahid  , Ika Puspitasari
Published: November 2023

A Freshwater fish is a popular type of fish consumed in Indonesia besides seawater fish. However, until now the most available information regarding the potential allergenicity of fish is only related to seawater fish. The potential allergenicity of freshwater fish has not been studied much, so it has not been identified and characterized. Based on this, this review aims to collect information regarding the potential allergenicity of protein in freshwater fish and the effect of processing on this potential. The potential allergenicity of proteins in several freshwater fish has been confirmed by immunoblotting and ELISA, namely mujair, nile, catfish, mas, toman, janjan, tambakan, tiger scat, barramundi, and eel. The identified allergenic proteins include parvalbumin, tropomyosin, enolase, aldolase, creatine kinase, triosephosphate isomerase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase. In addition, several proteins in other freshwater fish also have allergenicity potential but have not been confirmed through research, namely pomfret, gourami, snakehead, catfish, eel, betutu, and cetol. The potential allergenicity of fish protein is also influenced by the processing process. Changes in the potential allergenicity are related to the characteristics of each allergen protein. Therefore, it is necessary to select the appropriate processing so that potential allergenicity can be suppressed.
The Reform and Innovation of Combining College Student Management and Ideological and Political Education
Authors: Gong Hong
Published: November 2023

The amalgamation of civic and political education is the key to successful student management in colleges and universities, and its integration can bolster the management of students in these institutions. Instill ideological and political education in colleges and universities, thereby advancing both the physical and mental wellbeing of students. The amalgamation of professional and ideological/political knowledge can be augmented by it, thus augmenting students’ understanding of ideology and politics, and ultimately augmenting the ideological awareness of college students. The successful implementation of the aforementioned material necessitates the combined efforts of college instructors and scholars, aided by science and technology. Realizing the successful amalgamation of student administration and ideological instruction in universities and colleges. An examination of the correlation between student administration and ideological instruction in colleges and universities is the initial focus of the article, and the integration of these two elements is then evaluated for its worth. Analyzing student management and ideological education, strategies for cultivating students’ consciousness, and innovating teaching mode are then proposed to address existing issues. Enhancing the situation.
Bridging Theory and Practice in Private Higher Education: Pedagogical Innovations for the Digital Age
Authors: Zhao Na
Published: November 2023

With the application of big data in the information age, the popularization of artificial intelligence and the coming of the network society, the traditional university education model has been severely impacted and challenged. It is an inevitable trend for higher education to adapt to the new social development reality and make corresponding adjustment and reform. Traditional university education pays attention to the imparts of theoretical knowledge and the cultivation of practical ability, but in the information age, students can get rich information and knowledge through the Internet, thus weakening the monopoly of traditional education. In addition, the popularity of artificial intelligence technology also means that some traditional teaching activities can be replaced by automation and intelligence, and the value chain of traditional education has been reshaped. The rise of the network society has also posed new challenges to the traditional university education model. The network society is characterized by a high degree of information sharing and exchange, and students can access various online educational resources and learning opportunities through the network platform. Therefore, traditional university education needs to find a new positioning and role, pay more attention to cultivating innovative ability, practical ability and teamwork ability, and provide students with more competitive comprehensive ability. Faced with these challenges, higher education must make corresponding adjustments and changes. The article carries out relevant research and puts forward specific countermeasures, mainly to update the educational concept, change the educational mode, and focus on cultivating students’ innovative thinking and problem-solving ability. It is necessary to develop diversified educational resources, meet social needs, strengthen cooperation with industries and enterprises, and provide professional education that matches market demand. At the same time, it is also necessary to actively develop online and distance education, make full use of online platforms and technological means, and provide flexible and diverse learning opportunities.
Smart Headlight Dimmer using Raspberry Pi
Authors: Kurundkar Sangeeta
Published: November 2023

Abstract: Driving in low-lighting conditions can raise several challenges that may affect your safety at night. Due to darkness, low visibility is the most frequent issue that drivers have at night. It will be difficult to see obstacles, pedestrians and vehicles on the road and another important problem is glare of Oncoming headlights from high intensity beams of xenon or LED headlights of the front facing vehicles. This will lead to temporary blindness for the drivers. In this situation driving the vehicle is a challenging task. It will be difficult to drive with the traditional headlights in such conditions. It poses a serious threat, and many accidents are caused by temporary blindness. According to the Indian statistics, more than 60% of accidents occur during night time and the main reasons behind those accidents is headlights problems. The abrupt brightness experienced by the travellers is known as the Troxler Effect. However, there is an option in every vehicle weather to keep the headlight either high or low when the vehicle is coming from the front side and this is called as upper and dipper system. Some of the drivers do follow this system as the car approaches them at night but a lot of them do not. Due to which it led to the problem of lack of visibility on the road due to constant glare of the headlights. Heavy vehicle’s (like trucks and buses) have extremely powerful headlights which produce very high intensity lights that in turn result in fatal accidents. Truck and bus drivers will ignore to reduce the headlight intensity when small vehicles are approaching them. As we analyse the current highway situation, most of the goods and passenger transportation occur during night. In lots of time These vehicles jeopardise the safety of other people. There is no such system available which can automatically high and low beam those headlights of heavy vehicles and even high beams of small vehicles. To resolve this problem, The System should be developed so that when a car or bike approaches another vehicle then there should be automatic change in the upper and dipper mode of the lights and reduce the light intensity. So that accidents due to headlights can be reduced.
Evolution of Web Development Frameworks
Authors: Ritesh  , Yadav Ayush , Dubey Ashutosh , Prajapati Deepak , Srivastava Akarsh
Published: November 2023

Abstract: Webapps have now become an important part of our industry. Be it small or big business house,they all depend upon webapps to attract more audience The field of web development has very rich history and it is ever evolving. The internet’s everchanging nature and users’ and developers’ evolving needshave led to a dramatic shift in the ever-changing and dynamic world of web development in the last few decades. This review paper presents an in-depth analysis of theevolutionary journey of web development frameworks, fromthe early days of static web pages to the complex, feature-rich web applications of today. An eye–catching and aproper design can only attract the users which can only bedone using a good design framework. Libraries and classesthat offer a broad range of features called frameworks —frameworks layout a foundation of great architecture which is further used to build an application. Frameworks are the building blocks of a web application. They are the foundation upon which web applications are constructed. There are many frameworks for web development that support various programming languages. In this review paper, we will discuss some of the most important frameworks for web development. We will discuss the front-end framework, the back-end framework, and the databaseenvironment. Based on the information provided in thisreview, you can predict which framework will be mosteffective for increasing user engagement.
Blockchain Voting: A Step Towards Inclusive Democracy
Authors: Mande Smita , Rathi Purvesh , Rathi Parth , Rathod Chaitanya , Rathod Manish , Rathod Khushbu
Published: November 2023

Abstract: The online voting system that incorporates blockchain technology aims to transform the voting process by introducing upgraded trust, transparency and security. Through the utilization of a decentralized blockchain network, the proposed system ensures that each vote is securely recorded and verified, thereby establishing an immutable and tamper-resistant voting mechanism. One of the fundamental feature of the system is eligible voter verification. By leveraging blockchain's distributed nature, the system can verify the identity and eligibility of each voter, ensure that eligible individuals can only participate in the voting system. This authentication process adds an additional layer of security and helps prevent fraudulent activities. Secure vote casting is another crucial component of the proposed voting system. Through the utilization of blockchain, each and every vote is encrypted and securely stored in a decentralized manner. This ensures that votes cannot be altered or manipulated, providing a high level of integrity to the voting process. Additionally, the system emphasizes transparent result tallying. The decentralized nature of blockchain technology allows for the public verification of votes, enabling anyone to audit the voting process. This transparency enhances trust among voters, as it provides them with the ability to independently verify the accuracy of the election results. Overall, the proposed online voting system, empowered by blockchain technology, offers a transparent, secure and tamper-resistant solution for conducting elections. By leveraging the benefits of blockchain, such as decentralization and immutability, the system addresses the challenges faced by traditional voting systems and provides a more reliable and trustworthy platform for the democratic process. It has the potential to enhance the integrity of elections, increase voter turnout, and foster trust in the electoral system.
The effectiveness of environment-oriented e-books based on problem-based learning for problem-solving skills
Authors: Ningsih Wintari , Prayitno Baskoro Adi , Santosa Slamet
Published: November 2023

This study aims to test the effectiveness of using environment-oriented e-books based on Problem-Based Learning (PBL) to empower problem-solving skills. The research design used is a Nonrandomized Control Group, Pretest-Posttest Design. The study used a quasi-experimental method with a 2 x 2 factorial design. The research sample was 70, grade X students of Colomadu State High School. The sample was divided into two groups: the control group using powerpoint media and conventional learning models and the treatment group using PBL-based environment-oriented e-books. The material used in the research is ecosystems in biology subjects. The instrument used to obtain data on problem-solving skills is an essay test. Data analysis using ANCOVA (p = 0.05%) with pretest value as a covariate. The results showed that PBL-based environment-oriented e-books had the most significant increase in problem-solving skills scores compared to the control class.
LA INTELIGENCIA ARTIFICIAL (IA) Y SU APORTE A LA MERCADOTECNIA; PRIMEROS HALLAZGOS
Authors: Lara Felix Jesús Humberto , Lara Salazar Jóse Rosario , Mizquiz Reyes Victor Manuel
Published: November 2023

El objetivo del estudio es encontrar las áreas de interés que actualmente están trabajando en conjunto con la inteligencia artificial y la mercadotecnia. El método aplicado fue análisis bibliométrico técnica perteneciente a la cienciometría que da la oportunidad de analizar la actividad científica en determinado tiempo en diferentes motores de búsqueda, la información fue recolectada y analizada en el software Vosviewer. Resultados las bases de datos implementadas fueron Scopus, Web of Science y Dimensions encontrando 2,438 documentos que cumplieron con los criterios de refinamientos establecidos en la metodología. Los documentos están clasificados en 1,263 artículos, 132 capítulos de libro, 62 libros, 157 memorias de congresos, 94 revisiones de literatura y 9 editoriales, siendo el documento más citado “How artificial intelligence will change the future of marketing” con 1,581. Limitaciones los documentos analizados son solamente del áreas de administración y negocios. Hallazgos; en sus inicios la IA fue considerada fría, de baja confianza e insensible por los usuarios, pero el Covid-19 incremento su aceptación. La IA ha logrado replicar algunas acciones humanas, nutriéndose de los usuarios a base de enseñanza, la IA crea su inteligencia a partir de información proporcionada por los usuarios y consumidores de los productos y servicios que usan IA para atender la demanda de consumo, asimismo puede ayudar en actividades operativas en las empresas incluso de muy alto riesgo, además, hará emerger nuevas profesiones que aún no son descubiertas pero que, con el pasar del tiempo, irán surgiendo para abastecer muchas de aplicaciones de trabajos con IA.
EVOLUCIÓN DE LA COMUNICACIÓN DE INFORMACIÓN CORPORATIVA EN PÁGINAS WEB DE COMPAÑÍAS COTIZADAS LATINOAMERICANAS
Authors: Jarne Jarne José , Morales Parada Fernando
Published: November 2023

La transparencia corporativa es de mucha relevancia en un contexto de negocios mutinacionales y ha sufrido cambios a lo largo del tiempo. En este sentido, las prácticas de revelación que realicen las empresas son relevantes, en su forma y fondo, especialmente en mercados donde la regulación es diversa y la práctica de divulgación voluntaria sigue siendo amplia. Este trabajo tiene por objetivo evaluar la comunicación corporativa realizada en sitios web de 106 empresas latinas en dos momentos a lo largo del tiempo (2008 y 2018) y pone de manifiesto la relevancia del uso de la web como mecanismo de transparencia corporativa en compañías cotizadas de Argentina, Brasil, Chile y México. Existen diferencias significativas en los resultados de la muestra, observamos un gran desarrollo del asunto en Brasil e importantes avances en las divulgaciones no financieras. Entre las conclusiones se abre el debate del contenido a revelar y la necesidad de avanzar hacia regulaciones que mejoren los contenidos mínimos a divulgar en web corporativas, especialmente considerando la región y no países de forma aislada.
PENGEMBANGAN MEDIA POWTOON TERHADAP KEMATANGAN KARIER SISWA KELAS X
Authors: Rahman Isfira Reina , Mustika Ika , Rismawati Siddik Riesa
Published: November 2023

This study has the aim of developing a powtoon media on student career maturity. In this study using the Research and Development (R&D) method using a model from Brog and Gall. The subjects in this study were students of class X. The results of the study were 1. Product development stage a) Phase I Preliminary study. b) Phase II includes product design, product validation, product revision, product testing. 2. The eligibility of material experts, media experts, and practitioners gets a score in the "Very Eligible" category. 3. Responses from students in the limited and broad trials got scores in the "Very Eligible" category. 4. Product feasibility from material experts, media experts, practitioners and students that powtoon media is very feasible and can be used. It can be concluded that the powtoon media on the career maturity of class X students is very feasible and can be used.
EFEKTIVITAS PENGEMBANGAN MODUL BIMBINGAN KLASIKAL UNTUK KESADARAN DIRI PESERTA DIDIK KELAS VIII SMP FK BINA MUDA
Authors: Aulia Vita , Fatimah Siti , Manuardi Ardian Renata
Published: November 2023

Development of modules as a medium of innovation in guidance and counseling activities, especially in classical guidance services. This module is used as teaching material for service materials that are focused on the context of learners' self-awareness. This research uses an R&D method developed by Borg and Gall which was adapted to stage seven. The purpose of this study is to produce a product that has been tested by several experts such as material experts, media experts, and practitioner experts. The research subjects consisted of 39 students at SMP FK Bina Muda who were specially selected to measure product feasibility through modules. Based on the product testing results that have been obtained from several experts and the response of students, this module has an average percentage of 9 1.63% according to the criteria that this product is very feasible to use for the Junior High School level.  Meanwhile, the results of the t-test analysis on the pretest and posttest result data were obtained by sig. (2-tailed) by 0.000. Thus, the results of the research on the effectiveness of this analysis showed that there was a positive change between the use of modules and the self-awareness of class VIII students at SMP FK Bina Muda.
Clinical Outcomes of Patients With Variant Histology of Urothelial Carcinoma After Radical Cystectomy
Authors: Lee Dan Bee , Kim Jae Yeon , Lee Yun Ha , Song Won Hoon , Lee Seung Soo , Park Sung Woo , Nam Jong Kil
Published: November 2023

Purpose: The efficacy of standard chemotherapy or radical cystectomy in patients who have urothelial tumors with variant histology (VH) is very limited in terms of their prognosis. This study aimed to investigate the prognosis of bladder cancer (BC) patients with VH who underwent radical cystectomy (RC).Materials and Methods: We retrospectively evaluated 327 BC patients who underwent RC at Pusan National University Yangsan Hospital between February 2010 and June 2021. VH was categorized into less and more aggressive types according to the patient’s mortality risk relative to pure urothelial carcinoma (PUC). More aggressive types included micropapillary, plasmacytoid, and sarcomatoid variants. Less aggressive types comprised other variant types, including squamous differentiation, glandular differentiation, lipoid, and nested. Small cell carcinoma, pure adenocarcinoma, pure squamous cell carcinoma, and lymphoma BC were excluded from analysis. The progression-free survival (PFS) and overall survival (OS) rates were evaluated using Kaplan-Meier analysis and Cox regression.Results: After the exclusion of nonurothelial tumors, data from 299 patients were available for analysis. We identified 244 (74.6%) and 55 patients (16.8%) with PUC and urothelial carcinoma with VH, respectively. VH patients were categorized as having less aggressive (n=35) and more aggressive (n=20) types. Univariate analysis identified significant differences in PFS (p=0.031) between patients with PUC (n=244) and more aggressive VH (n=20). Multivariate analysis showed that more aggressive VH was significantly associated with OS and PFS. In the Kaplan-Meier analysis, a statistically significant difference was observed between PUC and more aggressive VH in OS and PFS.Conclusions: VH patients with more aggressive types showed more advanced TNM stages at presentation than PUC patients. Pathological upstaging after RC was more common in VH patients. Among VH patients, the presence of a more aggressive VH type can be an independent predictor of progression after RC, with a worse prognosis than that of PUC patients.
Preoperative Renal Artery Embolization Before Radical Nephrectomy for Nonmetastatic Renal Cell Carcinoma: A Propensity Score Matched Analysis
Authors: Noh Jin , Song Sang Hun , Jung Gyoohwan , Lee Sangchul , Hong Sung Kyu , Byun Seok Soo , Kim Jung Kwon
Published: November 2023

Purpose: This study investigated the effects of preoperative renal artery embolization (PRAE) before radical nephrectomy (RN) for advanced nonmetastatic renal cell carcinoma (RCC) on perioperative and oncologic outcomes.Materials and Methods: We analyzed 820 patients who had undergone RN for advanced nonmetastatic RCC (cT3-4/N0-1) between June 2003 and May 2022. Propensity score matching (PSM) at a 1:2 ratio was performed using the nearest-neighbor method, matching 121 PRAE patients to 242 controls. The primary endpoints included recurrence rate, overall survival, cancer-specific survival, and recurrence-free survival.Results: Before PSM, there were differences in sex (p=0.047), clinical stage (p=0.001), and the Fuhrman grade (p<0.001) between the 2 groups. After PSM, the baseline characteristics were well balanced. The mean age at operation was 58.2±13.0 years, and the median follow-up was 42.0 months. The postoperative transfusion rate was higher in PRAE group (18.2% vs. 10.7%, p=0.049). No significant differences were found between the PRAE and control groups in operation time (166.6±95.3 minutes vs. 155.5±74.2 minutes, p=0.263), estimated blood loss (360.4±732.0 mL vs. 293.4±596.6 mL, p=0.384), or length of hospital stay (7.7±4.9 days vs. 7.7±3.7 days, p=0.961) between the 2 groups. Recurrence was significantly less common in the PRAE group than in the control group (20.7% vs. 34.3%, p=0.007). No significant differences were found in cancer-specific death (8.3% vs. 9.1%, p=0.793) or overall death (8.3% vs. 12.0%, p=0.281). In multivariate logistic regression analysis, clinical T stage ≥3 (odds ratio [OR], 4.365; p<0.001), clinical N stage 1 (OR, 2.405; p=0.020) and no PRAE (OR, 2.293; p=0.004) were independent predictors of recurrence.Conclusions: Our results showed that PRAE was related to a lower recurrence rate. Thus, PRAE seems to be useful before RN for nonmetastatic RCC patients.
Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma
Authors: Nicaise Edouard H. , Schmeusser Benjamin N. , Shah Yash B. , Bilen Mehmet A. , Ogan Kenneth , Master Viraj A.
Published: November 2023

The purpose of this review is to provide an up-to-date understanding of the literature describing the impact of body composition on renal cell carcinoma (RCC) prognosis and outcomes. Although obesity is recognized as a risk factor for RCC development, overweight patients with localized and advanced RCC display more favorable outcomes than normal-weight individuals. However, obesity as measured by body mass index is a poor indicator of total body fat, fails to account for lean muscle mass, and inconsistently predicts perioperative and survival outcomes in RCC. Recent studies have suggested that objective measurements of lean and fat body masses from various compartments have strong prognostic utility. Low muscle mass (i.e., sarcopenia) and low visceral adiposity are often associated with poorer survival outcomes in localized and advanced RCC. These patients tend to experience higher rates of recurrence, progression, treatment failure, and death from kidney cancer. Given the influence of body composition in RCC outcomes, further characterization of the role of prehabilitation programs is warranted to evaluate the feasibility and efficacy of interventions targeting these modifiable factors.
Nonregional Lymph Node Metastasis as a Predictor of Early Progression When Using Androgen Receptor Targeting Agents in Patients With Metastatic Castration-Resistant Prostate Cancer Without Previous Chemotherapy
Authors: Kim Sihyeon , Rho Beom Yong , Kang Dong Hyuk , Chung Doo Yong
Published: November 2023

Purpose: In present, the use of androgen receptor targeting agents (ARTA) is one of the standard treatments for metastatic castration-resistant prostate cancer (mCRPC) without previous chemotherapy. However, some patients may experience early progression despite ARTA use. Therefore, we analyzed predictors of early progression.Materials and Methods: We retrospectively analyzed patients treated with ARTA for mCRPC before chemotherapy at Inha University Hospital. Patients were divided into an early progression group and a late progression group. The 2 groups were defined as a group that used ARTA for more than 1 year without progression and a group that did not. Clinical and pathological parameters were analyzed to evaluate the oncologic outcomes. Univariate and multivariate logistic regression analyses were used to predict progression markers.Results: The final analysis included 70 patients. The mean progression-free duration with ARTA use was 334.90±364.716 days. There were 44 and 26 patients in the early and late progression groups, respectively. Univariate and multivariate logistic regression analyses did not show statistically significant results for the ARTA medication type, body mass index, Gleason grade group, visceral metastasis, bone metastasis, regional lymph node (LN) metastasis, time to CRPC, and prostate-specific antigen kinetics. In contrast, age (odds ratio [OR], 1.154; 95% confidence interval [CI], 1.043–1.251) and nonregional LN metastasis (OR, 8.819; 95% CI, 1.165–66.746) were significantly associated with the progression-free duration of ARTA use in multivariate logistic regression analysis.Conclusions: We think that nonregional LN metastasis is a predictor of early progression when using ARTA in patients with mCRPC without previous chemotherapy.
Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type
Authors: Wee Chan Woo , Cho Jaeho
Published: November 2023

Renal cell carcinoma (RCC) has traditionally been considered one of the most radioresistant tumors based on in vitro and clinical studies that utilized a low biologically effective dose. However, recent studies have suggested that administering a higher radiation dose to RCC can lead to satisfactory local control and potentially long-lasting disease control. Thanks to significant advances in radiotherapy technology, it is now feasible to deliver higher radiation doses to tumors while preserving the organs at risk. Furthermore, over the past decade, a crucial role of radiotherapy has emerged in metastatic cancers, both for symptom palliation and for the elimination of tumor niches. This review discusses the current evidence and future perspectives concerning the role of radiotherapy in metastatic RCC.
Early Experience With Pembrolizumab in Bacillus Calmette-Guérin Unresponsive Non–Muscle-Invasive Bladder Cancer
Authors: Lee Chung Un , Song Wan , Kang Minyong , Sung Hyun Hwan , Jeon Hwang Gyun , Seo Seong Il , Jeon Seong Soo , Park Se Hoon , Jeong Byong Chang
Published: November 2023

Purpose: Radical cystectomy (RC) is recommended for patients with non–muscle-invasive bladder cancer (NMIBC) who are unresponsive to intravesical bacillus Calmette-Guérin (BCG) instillation. However, RC is a very risky treatment, and some patients cannot undergo RC due to old age, patient preference, and comorbidities. In this study, we investigated the efficacy of pembrolizumab, a programmed cell death protein 1 inhibitor, in patients with NMIBC unresponsive to intravesical BCG instillation.Materials and Methods: Between December 2016 and February 2023, 24 patients who experienced recurrence after BCG treatment and subsequently received pembrolizumab were enrolled. We evaluated the patients’ response to pembrolizumab therapy using urine cytology, cystoscopic examination (with/without biopsy), and/or computed tomography imaging. The primary endpoint was the complete response (CR) rate 3 months after the first dose of pembrolizumab. Patients were followed up every 3 months for the first 2 years and every 6 months thereafter. Kaplan-Meier survival analysis was used to illustrate CR and the individual treatment course was demonstrated.Results: The median follow-up period was 16 months (range, 2–68 months) and the median number of pembrolizumab administrations was 5 times (range, 3–39 times). Thirteen of the 18 patients (54.2%) with BCG-unresponsive NMIBC achieved CR at 3 months. The median duration of CR maintenance was 15 months (range, 5–47 months). Five patients (20.8%) showed no recurrence for 12 months after pembrolizumab administration. Seven patients underwent RC, and pathological reports showed T2 stage in 3 patients. To date, 1 patient (4.2%) has died.Conclusions: Our early experience with pembrolizumab treatment for BCG-unresponsive NMIBC showed better results than those of the KEYNOTE-057 trial, which reported a CR rate of 40% at 3 months. However, long-term data and more cases are required to establish pembrolizumab therapy in patients with BCG-unresponsive NMIBC in a real-world setting.
Predictive Factors of Abiraterone Response in Patients With High-Risk Metastatic Hormone-Sensitive Prostate Cancer
Authors: Cho Jaeyoung , Suh Jungyo , You Dalsan , Jeong In Gab , Hong Jun Hyuk , Ahn Hanjong , Lim Bumjin
Published: November 2023

Purpose: This study aimed to identify predictive factors for the response to abiraterone in patients with high-risk metastatic hormone-sensitive prostate cancer (mHSPC).Materials and Methods: This study analyzed the clinical characteristics of 167 patients with high-risk mHSPC who received abiraterone. Univariate and multivariable Cox proportional hazard regression analyses were conducted to identify predictive factors for castration-resistant prostate cancer (CRPC)-free survival and cancer-specific survival.Results: The mean age at presentation was 71.62±8.12 years. The prostate-specific antigen level was 218 ng/mL (interquartile range, 70–654 ng/mL). Of the 167 patients, 118 (72%) had a biopsy Gleason grade of 5, 43 patients (28.7%) had CRPC, and 30 patients (18.0%) died after a mean follow-up period of 13.5 months. In the multivariable Cox proportional hazard regression analyses for CRPC-free survival, a Gleason grade of 5 (hazard ratio [HR], 2.888; 95% confidence interval [CI], 1.133–7.361; p=0.026) and bone lesions ≥10 (HR, 4.194; 95% CI, 1.760–9.997; p=0.001) were significantly associated with CRPC-free survival. In the multivariable Cox proportional hazard regression analyses for cancer-specific survival, bone lesions ≥10 (HR, 3.185; 95% CI, 1.215–8.348; p=0.001) was significantly associated with cancer-specific survival.Conclusions: Patients with bone lesions ≥10 and Gleason grade of 5 are at higher risk of developing CRPC, and bone lesions ≥10 is at higher risk of cancer-specific survival in high-risk mHSPC treated with abiraterone.
Behavioral Analysis of Backdoor Malware Exploiting Heap Overflow Vulnerabilities Using Data Mining and Machine Learning
Authors: Khaliq Ali Raza , Ullah Subhan , Ahmad Tahir , Yadav Ashish , Majid M Imran
Published: November 2023

Backdoor malware remains a persistent and elusive threat that successfully evades conventional detection methods through intricate techniques, such as registry key concealment and API call manipulation. In this study, we introduce an approach to detect backdoor malware, drawing upon the diverse domains of cybersecurity. Our method combines static and dynamic analysis techniques with machine learning methodologies, particularly emphasizing classification and feature engineering. Through static analysis, we extract valuable raw features from malware binaries. Discerning the most significant attributes, we delve into the calling frequencies embedded within these raw features. Subsequently, these selected attributes undergo a meticulous refinement process facilitated by feature engineering techniques, culminating in a streamlined set of distinctive features. To accurately detect malware exploiting heap-based overflow vulnerabilities, we employ three distinct yet potent classifiers: J48, Naïve Bayes, and Simple Logistic. These classifiers are trained and tested using carefully curated feature sets. Our approach combines machine learning and data mining principles to develop a comprehensive malware detection methodology. We demonstrate the efficacy of our approach through rigorous validation using two distinct settings: a dedicated training/testing set and a comprehensive 10-fold validation. Our approach simultaneously achieves 90.29% and 84.46% accuracy in train/ test split and cross-validation strategies.
O que é não religião?
Authors: Taves Ann , Cruz Eduardo Rodrigues da
Published: November 2023

Do original What is Nonreligion? On the Virtues of a Meaning Systems Framework for Studying Nonreligious and Religious Worldviews in the Context of Everyday Life. Secularism and Nonreligion, v. 7, n. 9, pp.1-6, 2018. O tradutor agradece pela gentil autorização dada pela autora e pelos editores do periódico Secularism & Non-Religion
Bens de salvação e mercados religiosos
Authors: Stolz Jörg , Sanches Duarte Gustavo
Published: November 2023

Apesar do enorme sucesso do conceito de "mercados religiosos", ainda não está claro o que são "bens religiosos", e sob quais condições um "mercado religioso" de fato existe em uma determinada sociedade. O autor integra diferentes conceitos dos teóricos da escolha racional e de Max Weber em uma nova tipologia de bens religiosos individuais e sociais. A tipologia mostra que os mercados são apenas uma possibilidade entre tantas outras de produção, troca e alocação de bens religiosos. Além disso, ela ajuda a entender as condições em que os mercados podem ou não ser ferramentas teóricas importantes.
Pendampingan Membaca dan Menulis Aksara Jawa di Madrasah Baitus Solihin Kajor Wetan Selopamioro Imogiri Bantul
Authors: Suwardiyono Dian Nugroho
Published: November 2023

Kajor Wetan Village is an area that has a lot of Javanese art. There is a lot of cultural art here that continues to be preserved. One of the most basic things in culture is language. Java has its own unique script or letters, namely the Javanese script. Currently, many children are reluctant to learn about Javanese script. This is due to a lack of interest in learning Javanese script, this is of course a problem. Baitus Solihin Madrasah is the only madrasah in Kajor Wetan village. This madrasah is a gathering place for children in Kajor Wetan village. The assistance activity for reading and writing Javanese script aims to provide madrasah students with an understanding of local culture to strengthen religious teaching values and add cultural values in Kajor Wetan. This mentoring activity is divided into 3 parts over 2 days. The first day contains an explanation of the basics of Javanese script and practice reading Javanese script. The second day was filled with learning games and competitions in reading Javanese characters. In general, this mentoring activity has provided additional knowledge to madrasah students regarding Javanese script and has been able to add value to Kajor Wetan village as an arts village.

Key Word: Local culture, Javanese Alphabet, Reading and Writing, Cultural Vilage
Interest-Free Long-Term Loans for Empowering Development in India
Authors: Manoj Kumar Agarwal  , Samia Ansari
Published: November 2023

Interest-free long-term loans for capex to the Subnational Governments of India, under the Special Assistance to States for Capital Investment (SASCI) Scheme, would facilitate the effective implementation of the present developmental schemes and infrastructure projects across all the States in unison, thereby empowering development. The Central Government of India’s expedited release of capex loans to states is accelerating development spending and contributing to an increase in overall public capex. Consequently, this boost in public capex is also crowding in private capex. Given the reduction in GST compensation grants and borrowing limits, it would be more advantageous for the State Governments to fully utilize the additional borrowing as interest-free loans for capital expenditures.
PENDEKATAN PSIKOLOGIS DALAM MENENTUKAN MINAT BERWIRAUSAHA MAHASISWA
Authors: Suasana I Gst. A. Kt. Gd , Warmika I Gde Ketut
Published: November 2023

Kewirausahaan memainkan peran yang semakin nyata, karena dapat berkontribusi pada pembangunan ekonomi dan penciptaan lapangan kerja. Tujuan penelitian adalah menjelaskan pengaruh faktor-faktor psikologis terhadap minat berwirausaha, dan menemukan model dengan kombinasi faktor-faktor psikologis terbaik di dalam model yang dapat dijadikan prediktor minat berwirausaha. Responden adalah mahasiswa yang pernah atau sedang mengikuti mata kuliah kewirausahaan di FEB Unud. Ukuran sampel ditentukan sebanyak 120 orang dengan purposive sampling dan data dianalisis menggunakan regresi linier berganda. Analisis metode enter menemukan bahwa faktor psikologis berpengaruh signifikan terhadap minat berwirausaha, dan hanya kebutuhan untuk berprestasi serta lokus kontrol internal berpengaruh positif dan signifikan terhadap minat berwirausaha. Berdasarkan metode stepwise, ditemukan bahwa kombinasi antara kebutuhan untuk berprestasi, lokus kontrol internal, dan toleransi terhadap ambiguitas adalah prediktor terbaik dari minat berwirausaha. Implikasinya, penguatan faktor psikologis bagi mahasiswa dapat didekati dengan pelatihan motivasi wirausaha dengan melibatkan role model wirausaha sukses. Peneliti selanjutnya, perlu mengkaji dan mengidentifikasi faktor psikologid lain, untuk lebih memperkuat hasil analisis, seperti kreativitas dan komunikasi.
PENILAIAN KINERJA PEGAWAI APARATUR SIPIL NEGARA BADAN PENELITIAN DAN PENGEMBANGAN DAERAH KABUPATEN LAMPUNG TENGAH DENGAN PENDEKATAN IMPORTANCE PERFORMANCE ANALYSIS
Authors: Supomo Supomo , Suhada Bambang , Suharto Suharto
Published: November 2023

This study aims to measure the performance of State Apparatus Employees (ASN) at the Central Lampung Regional Research and Development Agency. Assessment This study only uses services as an independent variable. In this study, 27 ASNs were involved as questionnaire respondents using the census method. Data testing techniques used in this study include validity testing with factor analysis, reliability testing, gaps, and Importance and Performance Analysis (IPA). IPA is a research method by comparing the level of importance with the level of implementation. The results showed that the results of the performance appraisal integrity and integrity are not important. Based on the research results, the most important attribute is increasing the priority to be done in order to remain competitive. Meanwhile, attributes that are deemed less important do not require temporary repairs, if necessary they are ignored or eliminated.
ANALSIS STRATEGI DALAM PENINGKATANPENERIMAAN PAJAKHIBURAN DIKABUPATEN LAMPUNG TENGAH
Authors: Sandra Sari Uci , Suhada Bambang , Suharto Suharto
Published: November 2023

Sumber-sumber pendanaan pelaksanaan Pemerintahan Daerah terdiri atas Pendapatan Asli Daerah, Dana Perimbangan, Pinjaman Daerah, dan lain-lain pendapatan yang sah. Dalam usaha untuk meningkatkan penerimaan pajak daerah, pajak hiburan sangat berperan sesuai dengan perkembangannya. Oleh karena itu, pemerintah daerah dapat menjadikan bisnis hiburan sebagai salah satu sumber yang potensial untuk dikenakan pajak. Lahan yang memiliki potensial dalam meningkatkan peneriman pajak hiburan yaitu dimana jika ada daerah-daerah yang memiliki tempat wisata dan juga didalamnya terdapat usaha hiburan. Jenis penelitian yang digunakan penulis berupa penelitian deskriptif yangbertujuan untuk membuat deskripsi secara actual dan sistematis mengenai fakta dan sifat data, yang penelitiannya menggunakan sebagai subjek informasi untuk masalah masalah yang akan diteliti. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Penelitian ini akan mengacu pada penelitian kualitatif dengan analisis SWOT (Strenght, Weakness, Opportunity, Threats). Berdasarkan hasil analisis SWOT yang dilakukan fokus strategi dalam meningkatkan penerimaan pajak hiburan di Kabupaten Lampung Tengah dapat mengguakan stretegi SO (Strengths – Opportunity) sebagai berikut : (1). Menambah kuantitas serta kualitas sumber daya manusia bidang penagihan, kontroling dan pemeriksa pajak; (2). Optimalisasi penerimaan dengan intensifikasi dan ekstesifikasi pajak hiburan guna meningkatkan penerimaan pajak hiburan; (3). Manambah penggunaan alat perekam online (tapping box) dalam upaya monitoring dan akuntabilitas pelaporan pajak self Assesment seperti pajak hiburan; (4). Menambah anggaran yang ditujukan sebagai reward petugas lapangan dalam memantau berjalannya semua program yang dijalankan dalam upaya meningkatkan penerimaan pajak hiburan;
PENGARUH KOMPETENSI DAN KINERJA PEGAWAI TERHADAP KUALITAS PELAYANAN PUBLIK DI KANTOR KECAMATAN PUTRA RUMBIA KABUPATEN LAMPUNG TENGAH LAMPUNG
Authors: Irawan Ferri , Suharto Suharto , Mazni Afdal
Published: November 2023

Kualitas pelayanan publik mengacu pada tindakan atau kegiatan yang diberikan yang berdampak pada kapasitas untuk mencapai kualitas terbaik untuk memenuhi harapan masyarakat. Kinerja karyawan dan aspek terkait kompetensi mempengaruhi seberapa baik layanan diberikan. Penelitian ini bertujuan untuk menguji (1) pengaruh kompetensi pegawai terhadap kualitas pelayanan publik di Kantor Kecamatan Putra Rumbia Kabupaten Lampung Tengah Lampung; (2) pengaruh kinerja pegawai terhadap kualitas pelayanan publik di Kantor Kecamatan Putra Rumbia Kabupaten Lampung Tengah Lampung; dan (3) pengaruh gabungan kompetensi dan kinerja pegawai terhadap kualitas pelayanan publik di Kantor Kecamatan Putra Rumbia, dengan menggunakan rumus Slovin diambil sampel sebanyak 100 responden dari populasi sebanyak 20.377. menggunakan regresi sebagai alat penelitian dan memperoleh data ini melalui kuesioner. (1) Terdapat pengaruh positif dan signifikan kompetensi pegawai terhadap kualitas pelayanan publik di Kantor Kecamatan Putra Rumbia Kabupaten Lampung Tengah Lampung sebesar 38,5%; (2) Terdapat pengaruh positif dan signifikan kinerja pegawai terhadap kualitas pelayanan publik di Kantor Kecamatan Putra Rumbia Kabupaten Lampung Tengah Lampung sebesar 37,3%; dan (3) Terdapat pengaruh positif dan signifikan sikap pegawai terhadap kualitas pelayanan publik di Kantor Kecamatan Putra Rumbia Berdasarkan temuan penelitian, semakin tinggi kompetensi dan efektifitas pegawai semakin memberikan kontribusi positif terhadap kualitas pelayanan publik.
PENGARUH KOMPETENSI PETUGAS DAN DISIPLIN KERJA TERHADAP KUALITAS PELAYANAN INSEMINASI BUATAN (IB) PADA SAPI DI KECAMATAN WAY SEPUTIH KABUPATEN LAMPUNG TENGAH
Authors: Solikin Solikin , Suharto Suharto , Mazni Afdal
Published: November 2023

Di Kecamatan Way Seputih Kabupaten Lampung Tengah telah ada petugas Inseminasi Buatan (IB), namun karena jumlahnya yang terbatas dan pendidikan yang dimiliki juga tidak berlatar belang pendidikan peternakan, maka sering memberikan pelayanan Inseminasi Buatan (IB) pada sapi yang menyebabkan sapi setelah dilakukan Inseminasi Buatan (IB) gagal bunting. Selain itu karena tempat domisili petugas yang berjauhan dengan pembagian tempat kerja dan belum adanya posko pengaduan Inseminasi Buatan (IB) pada sapi, menyebabkan petani peternak sapi terlambat melaporkan masa birahi sapi, sehingga harus menunggu masa birahi kembali baru dilakukan Inseminasi Buatan (IB). Selain itu kurang disiplinya petugas Inseminasi Buatan (IB) untuk segera memberikan pelayanan Inseminasi Buatan (IB) juga menjadi faktor kegagalan dalam Inseminasi Buatan (IB). Permasalahan lain yang muncul adalah petugas tidak dapat dihubungi nomor Hand Phone (HP)-nya saat ada sapi yang sedang birahi mengakibatkan birahi sapi terlewati sehingga petani peternak masih harus menunggu 21 hari lagi untuk mendapatkan masa birahi sapi.

Populasi sebanyak 155 petani peternak sapi dengan sampel yang digunakan sebanyak 34 responden. Pengambilan data ini dengan mengunakan quisioner sebagai alat bantu penelitian. Hasil analisis yang diperoleh ada pengaruh kompetensi petugas terhadap kualitas pelayanan Inseminasi Buatan (IB) pada sapi di Kecamatan Way Seputih Kab Lamteng. Dari hasil uji F diketahui ada pengaruh kompetensi petugas dan disiplin kerja terhadap kualitas pelayanan Inseminasi Buatan (IB) pada sapi di Kecamatan Way Seputih Kab Lamteng. Koefisien nilai R menunjukan keeratan pengaruh antara kompetensi petugas dan disiplin kerja terhadap kualitas pelayanan Inseminasi Buatan (IB) pada sapi di Kecamatan Way Seputih Kab Lamteng tergolong kategori sedang.
Nonlinear fourth-order dynamic equations on unbounded time scales
Authors:   Khazar University, Department of Mathematics, AZ1096 Baku, Azerbaijan, Allahverdiev Bilender , Tuna Hüseyin ,   Mehmet Akif Ersoy University, Department of Mathematics, 15030 Burdur, Turkey
Published: November 2023

"In this paper, we investigate nonlinear fourth-order dynamic equations on unbounded time scales. The existence and uniqueness of the solutions for these problems are obtained."
On the Goldie dimension of finitely generated locally cyclic modules
Authors:   University Sidi Mohamed Ben Abdellah, Faculty of Sciences Dhar El Mahraz, Fez, Morocco, Boudine Brahim , Moindze Soibri ,   University of Comoros, Faculty of Sciences and Techniques, Moroni, Comores
Published: November 2023

Let R be a commutative ring with identity. In this paper we investigate the Goldie dimension of finitely generated locally cyclic R-modules. Then, we give a characterization of rings whose finitely generated locally cyclics have finite Goldie dimension.