bluuebunny/crossref_metadata_2025 huggingface dataset:
Topical Nano-emulgel for Skin Disorders: Formulation Approach and Characterization
Authors: Ahmad Javed , Gautam Anuj , Komath Shahadali , Bano Mehdiya , Garg Anuj , Jain Keerti
Published: November 2018

Background:

Acne vulgaris is a common chronic skin disease that affects around
9.4% (approx. 650 million people) of the global population. Growing research in the field of
nanomedicine over the years has now been exploited in management of various human disorders.
The nanomedicine concept has an immense opportunity for the effective management
and control of acne disease by designing a novel, low-dose topical delivery system. Topical
nanoemulsion-based gel preparations are said to have various benefits over the conventional
formulations. The recent patents on topical anti-acne formulation (US 7241456B2; US
6897238B2; US 6284234B1) provided the concept to design thymol loaded nano-emulgel
for topical application in acne.

Methods:

The objective of the current investigation was to design a thymol loaded nanoemulgel
preparation by exploiting low-energy emulsification method for topical application
in acne. Furthermore, developed formulation was characterized for thermodynamic stability,
mean droplet size, zeta potential, drug content and in-vitro drug diffusion study.

Results:

The optimized thymol loaded nanoemulsion was found to be 13.60±0.117 nm with
PdI 0.197±0.008. Nanoemulsions will provide an enormous surface area for better penetration
of therapeutic agent into the pilosebaceous region, resulting better efficacy.

Conclusion:

From the above studies, it concluded that aqueous-based gel vehicle of the
developed formulation system exploited for topical delivery has moisturising properties
which can improve local tolerability also.
Single-chain Antibody Against Reg4 Suppresses Gastric Cancer Cell Growth and Enhances 5-FU-induced Cell Death in vitro
Authors: Zhang Xue-Qing , Yu Lu-Ting , Du Pei , Yin Tian-Qi , Zhang Zhi-Yuan , Xu Ying , Li Xiang , Li You-Jie , Wang Min , Luo Chen
Published: November 2018

Background:

Regenerating islet-derived gene family member 4 (Reg4), a well-investigated growth factor in the regenerative pancreas, has recently been reported to be highly associated with a majority of gastrointestinal cancers. Pathological hyper-expression or artificial over-expression of Reg4 causes acceleration of tumor growth, migration, and resistance to chemotherapeutic 5-Fluorouracil (5-FU). Until now, no method has been successfully established for eliminating the effects of Reg4 protein.

Methods:

This study reports the production of an engineered immunoglobin, a single-chain variable fragment (scFv-Reg4), to specifically bind Reg4 and block the bioactivity. The complementary-determining regions (CDRs) against Reg4 were assigned using MOE and ZDOCK servers. The binding affinity (KD) was determined by bio-layer interferometry (BLI). MKN45 and AGS cell proliferation was determined by Thiazolyl blue tetrazolium bromide (MTT) method and the cell apoptosis was detected by flow cytometry assay.

Results:

The KD of scFv-Reg4 to Reg4 was determined to be 1.91×10-8. In MKN45 and AGS cell lines, scFv- Reg4 depressed Reg4-stimulated cell proliferation and the inhibitory rates were 27.7±1.5% and 17.3±2.6%, respectively. Furthermore, scFv significantly enhanced 5-FU-induced cell death, from 23.0±1.0% to 28.4±1.2% in MKN45 and 28.2±0.7% to 36.6±0.6% in AGS cells. Treatment with scFv alone could lyse cancer cells to a certain extent, but no significance has been observed.

Conclusion:

The single-chain antibody (scFv-Reg4) significantly inhibited gastric cancer cell proliferation and synergistically enhanced the lethal effect of 5-FU. Thus, traditional chemo-/radio- therapeutics supplemented with scFv-Reg4 may provide advances in the strategy for gastrointestinal cancer treatment.
Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase
Authors: Królewska-Golińska Karolina , Cieślak Marcin J. , Sobczak Milena , Dolot Rafał , Radzikowska-Cieciura Ewa , Napiórkowska Mariola , Wybrańska Iwona , Nawrot Barbara
Published: November 2018

Background:

Novel derivatives of benzo[b]furan were found to be highly toxic towards human chronic myelogenous (K562), acute myelogenous (HL-60) and acute lymphoblastic (MOLT-4) leukemia cells.

Objective:

The objective was the characterization of the biological activity of novel benzofurans (influence on apoptosis, mitogen-activated protein kinases and on the cell cycle). Cellular protein(s) targeted by test benzofurans and mechanism of action were identified.

Methods:

The methods utilized in the study were chemical synthesis, fluorescence assays, flow cytometry, gene expression by DNA microarray and real-time RT-PCR, western blotting, cytotoxicity assays, pull-down assay, mass spectroscopy, in vitro polymerization of tubulin, molecular docking.

Results:

1,1'-[3-(bromomethyl)-5,6- dimethoxy-1-benzofuran-2,7-diyldiethanone (1) and methyl 4-bromo-6- (dibromoacetyl)-5-hydroxy-2-methyl-1-benzofuran-3-carboxylate (2) induced apoptosis in K562 and MOLT-4 cells. The profiling of gene expression revealed that 1 and 2 increased the expression of proapoptotic genes involved in both receptor (TNFRSF 10A, TNFRSF 10B, CASP8) and mitochondrial (BAX, BID, NOXA, APAF1) pathways of apoptosis. Test benzo[b]furans activated c-Jun N-terminal kinase (JNK) and p38 kinase in K562 cells. Tubulin was identified as a protein target for benzo[b]furans in pull-down experiments with biotinylated 2. Test benzo[b]furans inhibited polymerization of tubulin monomers in vitro, decreased the level of cellular microtubules and arrested cells in a G2/M phase. Molecular docking suggests that benzo[b]furans 1 and 2 bind to tubulin via colchicine binding pocket and the complex is stabilized mainly by hydrophobic interactions.

Conclusion:

Novel benzo[b]furans with anti-microtubule activity were identified. They induce apoptosis in cancer cells and cause G2/M cell cycle arrest. Biological activity of 1 and 2 makes them potential lead compounds for development as anticancer drugs.
Biodistribution, Safety and Organ Toxicity of Docetaxel-Loaded in HER-2 Aptamer Conjugated Ecoflex® Nanoparticles in a Mouse Xenograft Model of Ovarian Cancer
Authors: Ghassami Erfaneh , Varshosaz Jaleh , Minaiyan Mohsen , Nasirikenari Mehrab , Hoseini Seyed M.
Published: November 2018

Background:

Docetaxel is a notably efficient anticancer drug administered for several types of malignancies including ovarian cancer. However, various side effects caused either by the nonspecific distribution of the active ingredient or by high contents of Tween 80 and ethanol in the currently marketed formulations, could even deprive the patients of the treatment.

Objectives:

In the current study, a novel targeted delivery system composed of Ecoflex® polymeric nanoparticles loaded with docetaxel and equipped with HER-2 specific aptamer molecules was evaluated regarding blood and tissue toxicity, and biodistribution.

Method:

The tumor-bearing nude mice, achieved by subcutaneous injection of SKOV-3 cells, were divided into four groups treated with normal saline, Taxotere®, targeted docetaxel nanoparticles, and non-targeted docetaxel nanoparticles. Few patents were alos cied in the article.

Results:

According to the results of hematologic evaluations, almost all hematologic parameters were in normal range with no significant difference among the four groups. Histopathological studies revealed that treatment with targeted nanoparticles caused a remarkable reduction in mitosis in tumor sections and overall reduced organ toxicity compared with Taxotere®. The only exception was spleen in which more damage was caused by the nanoparticles. The results of the biodistribution study were also in accordance with pathological assessments, with significantly lower drug concentration in non-tumor tissues, except for spleen, when targeted nanoparticles were used compared with Taxotere®.

Conclusion:

These results could evidence the efficiency of the targeted delivery system in concentrating the drug cargo mostly in its site of action leading to the elimination of its adverse effects caused by exposure of other tissues to the cytotoxic agent.
Operation Scenario and Coordination Control of DC Grid with DC-DC Converters
Authors: Wang Meiyan , Li Ke-Jun , Sun Kaiqi , Liu Zhijie
Published: November 2018

Background:

With the increasing development of voltage source converter based high
voltage direct current (HVDC), it will become a reality to interconnect different DC networks into
DC grid with DC-DC converters.

Methods:

In this paper, three operation scenarios for the DC grid with DC-DC converters are proposed,
by which the DC networks can reinforce each other with relative independence. In order to
achieve the flexible switching of the proposed scenarios, the DC-DC combined control and principle
of parameter selection are presented. In addition, two coordination controls for different scenarios are
given to optimize the distribution of unbalanced power when the disturbances occur in the grid. With
the proposed scenarios and control strategy, the impacts caused by the disturbances are alleviated and
the uninterrupted operation of the grid is guaranteed.

Results:

A simulation model is established on the PSCAD/EMTDC and the simulation results verify
the effectiveness of the proposed operation scenarios and control strategy.

Conclusion:

Finally, the effectiveness of the proposed operation scenarios and control strategy is verified
by the simulation results in PSCAD/EMTDC.
Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study (Preprint)
Authors: Hewlings Susan , Kalman Douglas S
Published: November 2018

BACKGROUND

The sulfur-containing compound methylsulfonylmethane (MSM) has been used as a dietary supplement for a variety of reported health benefits. Clinical observations and case studies have indicated that MSM may help alleviate allergic rhinitis; however, this effect has not been evaluated under controlled conditions.

OBJECTIVE

This study aimed to determine the effects of MSM consumption on allergic rhinitis symptoms after provocation with a standardized allergen.

METHODS

We recruited healthy participants with a history of allergic nasal congestion to participate in a randomized, double-blind, adaptive-design study. Participants were administered a standardized allergen in clinic to determine the presence or absence of an allergic response. Participant responses were recorded using a recognized measure of nasal patency, peak nasal inspiratory flow (PNIF), and by a visual analog scale to score the severity of their allergy-related nasal symptoms. After we collected baseline nasal responses to allergen, followed by a 1-week washout period, participants returned to the clinic and were exposed to allergen after taking an acute high dose of 12 g of MSM. We then randomly assigned participants to a lower dose of MSM (1 g, 3 g, or 6 g), which they consumed once a day for 14 days. Participants returned to the clinic for repeat assessments while again taking their assigned daily dose of MSM.

RESULTS

All MSM treatment courses significantly reduced visual analog scale average nasal symptoms in a longitudinal comparison across all participants, with low-dose treatments decreasing symptoms by 53.72% (P=.001), and an acute 12-g dose decreasing symptoms by 22.49% (P=.03). Although the acute dose of MSM did not yield significant changes in nasal patency, low “everyday” doses significantly relieved nasal obstruction as indicated by a 17.32% (P=.02) increase in PNIF across all participants. The most effective dose across all measurements was daily consumption of 3 g of MSM, which significantly decreased all nasal symptoms (nasal obstruction, rhinorrhea, watery or itchy eyes and nose, and sneezing) and further was found to significantly (P=.01) increase PNIF.

CONCLUSIONS

The MSM study product provided significant relief of allergic rhinitis symptoms and objective nasal obstruction measurements without the occurrence of adverse events. Oral consumption of the study product may reduce the symptoms and onset of allergic rhinitis without the side effects associated with standard-care medication.

CLINICALTRIAL

ClinicalTrials.gov NCT02342483; https://clinicaltrials.gov/ct2/show/NCT02342483 (Archived by WebCite at http://www.webcitation.org/73vLKNvAp)

INTERNATIONAL REGISTERED REPOR

RR1-10.2196/11139
Use of Agro-Industrial By-Products in Animal Feed at Modern and Semi-Modern Farms of Urban Community of Niamey (UCN): State Places
Authors: Mouctari Ousseini M. M. , Chaibou Mahamadou , Sitou Moustapha I. , I. Tondi Abdoul Razak , Mamman Mani
Published: November 2018

The study was conducted in Urban Community of Niamey at modern and semi-modern farms provided an overview use of agro-industrial by-products in animal feed. Among 57 farms only 17 farms, including 10 beef farms, 2 sheep farms and 5 poultry farms were systematically surveyed. All farm managers are men. 60 and 33% are respectively officials at the level of poultry farms and ruminant farms. Farmers make up 25%, all of which own beef farms. There is also a predominance of adults, 60% at poultry level and 58.33% at ruminant farms. We note the use of a variety of agro-industrial by-products in animal feeds, in this case by-products derived from vegetable processing (wheat bran, exfoliated cotton cake) and animal processing (fish and fish meal ...). There are also some concentrates for poultry feed. Agribusiness by-products are increasingly used in urban livestock production but their valorization needs to be improved.
Un acercamiento al concepto de la innovación en los servicios públicos
Authors: Arguelles Toache Eugenio , Villavicencio Carbajal Daniel H.
Published: November 2018

La innovación en el sector público ha sido poco abordada por los estudios sobre innovación y administración pública. Partiendo de la evolución del enfoque que ha definido la problemática, el artículo plantea desde una perspectiva teórica, el concepto de innovación en el sector público, las dimensiones que comprende, su aplicación y las diferencias con respecto a la innovación en el sector privado. Las características organizacionales y la naturaleza de los servicios públicos obligan a pensar la innovación desde una perspectiva distinta a la que ocurre en las empresas industriales. El objetivo es presentar una propuesta del concepto de innovación en servicios públicos retomando distintas categorías de análisis, enfatizando en dos dimensiones particulares: el valor de uso y el valor público.
Pueblo, populismo y democracia
Authors: Oyarzún R. Pablo
Published: November 2018

En lo que sigue intentaré una aproximación a lo que el título de este coloquio llama “dos conceptos tensos”, al tiempo que los resguarda con la debida prudencia (o quizá los expone con dejo de ironía) entre comillas simples: ‘pueblo’ y ‘populismo’.  Dispondré mi aproximación en tres partes. En la primera me referiré a la noción de “pueblo” teniendo a la vista lo que se podría considerar su gramática populista. Luego ensayaré algunas reflexiones sobre la división de campo que el populismo instala con su apelación al “pueblo” o a cualquiera de las otras magnitudes que tengan similar función en su retórica: será, pues, la cuestión del antagonismo, la partición del espacio social y del espacio del poder entre “ellos” y “nosotros”. Por último, en la expectativa de que lo anterior prepare el paso, será cuestión de la democracia como aquello que en última instancia está en juego en el ambiguo desafío del populismo.
KUALITAS HIDUP LANSIA DITINJAU DARI SABAR DAN DUKUNGAN SOSIAL
Authors: Sari Devi Maya Puspita , Lestari Canina Yustisia Dwi , Putra Evan Chairul , Nashori Fuad
Published: November 2018

Elderly is one of development periods characterized by physical, psychological, and social degeneration that can decrease the quality of life. Quality of life can be improved by social support and sabr as a coping strategy to overcome the problems that occur in elderly periods. This research aimed to analyze the correlation between sabr and social support with quality of life of elders in Yogyakarta. The number of subjects is 24 men and 34 women which is chosen by purposive sampling. Data was collected by WHOQOL, patience instrument, and MSPSS. Multiple linear regression was used to analyze multivariate correlation and pearson correlation was used to analyze the bivariate correlation. This suggest that there was a significant positive correlation between sabr, social support and quality of life of elders. In the other words, quality of life can be predicted based on sabr and social support.  Keyword : Quality of life, Patience, Social Support, Elderly
Psikoedukasi untuk meningkatkan parenting self-efficacy pada ibu anak penyandang autisme
Authors: Purbasafir Trialovena Firizbrilian , Fasikha Siti Suminarti , Saraswati Putri
Published: November 2018

Abstrak. Mengasuh anak dengan autis merupakan tantangan bagi orang tua terutama ibu. Untuk menghadapi tantangan tersebut dibutuhkan Parenting self-efficacy yang tinggi untuk menghadapi stressor yang muncul selama proses pengasuhan. Psikoedukasi menjadi salah satu metode intervensi yang efektif untuk meningkatkan variabel tersebut, melalui kesiapan kognitif dengan memberikan pemahaman dan informasi baru. Subjek penelitian ini adalah orang tua siswa di Pusat Layanan Autis Malang sebanyak 4 orang yang diambil dengan teknik pengambilan sampel purposive sampling. Penelitian ini merupakan penelitian pre eksperimen dengan desain one group pretest posttest. Hasil penelitian menunjukkan adanya pengaruh psikoedukasi terhadap parenting-self efficacy orang tua sebelum dan sesudah pemberian psikoedukasi ditunjukkan dengan hasil uji wilcoxon. Hasil menunjukkan bahwa psikoedukasi dapat digunakan untuk meningkatkan parenting self-efficacy pada ibu anak penyandang autis.Kata Kunci: psikoedukasi, parenting self-efficacy, ibu dengan anak autisAbstract. Parenting a child with autism disorder is a great challenge for the mother. Hence, the ideal parenting self-efficacy is needed to face stressor which appears increases the variable through up to date information. The study selects four parents at Autism Services Center using purposive technique sampling. This study applied pre-experimental design with one group pre-test and post-test. The results of the study showed that psychoeducation influences parenting self-efficacy before and after giving treatment which showed by Wilcoxon test. Result showed that psychoeducation is highly important to improve parenting self-efficacy among mother to the children with autism disorder. Keywords:  psychoeducation, parenting self-efficacy, mother, child with autism disorder
Hubungan kesepian dan pengungkapan diri di instagram pada dewasa yang belum menikah
Authors: Anggraeni Nora , Zulfiana Uun
Published: November 2018

Abstrak. Penggunaan media sosial salah satunya instagram sebagai wadah berbagi informasi untuk mengatasi perasaan kesepian yang dirasakan akibat ketiadaan hubungan dengan individu lain di dunia nyata. Sebagian individu yang telah memasuki fase dewasa masih belum mampu untuk memenuhi kebutuhan berhubungan dengan orang lain. Salah satu cara yang dilakukan dengan membentuk komitmen untuk membangun sebuah pernikahan. Tujuan dalam penelitian ini untuk mengetahui hubungan antara kesepian dengan pengungkapan diri di instagram pada dewasa yang belum menikah. Penelitian ini merupakan penelitian kuantitatif korelasional dengan sampel sejumlah 260 orang yang diambil menggunakan teknik nonprobability sampling jenis purposive sampling. Pengambilan data menggunakan skala pengungkapan diri dan kesepian yang dianalisis menggunakan korelasi Spearman. Hasil menunjukkan tidak ada hubungan antara kesepian dan pengungkapan diri di instagram pada dewasa yang belum menikah.Kata Kunci: Kesepian, Pengungkapan Diri, Dewasa Belum MenikahAbstract. Exchanging information is one of the leading reasons social media is frequently used nowadays. Instagram for instance, its presence is not only for sharing information to others but also for surmounting solitude as result of social interaction absence in reality. For individuals who have been indicated as adults, the ability to do interaction to others is incapable, marriage commitment as an example. This current study is aimed to find out the relation between loneliness and self-disclosure through instagram for unmarried adults. In this current study used correlational quantitative method in which 260 research participants were recruited by employing nonprobability sampling technique with purposive sampling type. The assembled data taken by using scale of loneliness and self-disclosure and analysed by way of Spearmen correlation. The results have shown that there are no relations between solitude and self-disclosure through instagram for unmarried adults. Keywords:  Loneliness, Self-disclosure, Unmarried Adults
Pembatasan Jumlah Mahar Melalui Keputusan Musyawarah Adat Kluet Timur
Authors: A. Gani Burhanuddin , Ainun Hayati Ainun Hayati
Published: November 2018

Mahar merupakan pemberian wajib dari calon suami kepada calon istri sebagai bentuk dari aplikasi perintah syarâ€™i. Ketentuan pemberian mahar dalam Islam tidak ditentukan jumlah dan bentuknya. Namun, hal ini berbeda dengan praktek yang dilakukan oleh masyarakat kecamatan Kluet Timur yang menetapkan standar mahar. Penelitian ini membahas aspek yang melatarbelakangi pembatasan jumlah mahar yang ditetapkan oleh masyarakat adat kecamatan Kluet Timur dan tinjauan fiqh terhadap praktek pembatasan jumlah mahar yang telah ditetapkan masyarakat adat kecamatan Kluet Timur. Artikel ini menggunakan metode penelitian yuridis sosiologis yaitu penelitian terhadap identifikasi hukum dan efektifitas hukum. Teknik pengumpulan data dalam penelitian ini melalui wawancara, dokumentasi dan observasi. Hasil penelitian menunjukkan bahwa yang melatarbelakangi pembatasan mahar tersebut dipengaruhi oleh beberapa faktor yaitu faktor agama, ekonomi, sosial, dan budaya. Adapun pandangan fikih terhadap pembatasan mahar tersebut ialah jika pembatasan pemberian mahar tersebut atas dasar paksaan, dibujuk atau tipu muslihat maka hukumnya tidak boleh diterima, karena telah mendzalimi calon suami, begitu pula sebaliknya.
Measuring Social and Psychological Outcomes from Activation Labour Market Programmes in Higher Education: A Pilot Study
Authors: Hogarty Vanessa Long , Mc Guckin Conor
Published: November 2018

Following the 2008 recession, Ireland experienced unemployment rates as high as 15% (McGuinness, O’Connell and Kelly, 2014). Policy responses have been through the introduction of upskilling and reskilling through activation labour market policies (ALMPs) in the higher education sector (Department of Education and Skills, 2015).  The evidence to date regarding the efficacy of such interventions (e.g., Springboard+) has been concerned with blunt measurements of progression rates, labour market entry, and earnings. The present study explored social capital and social well-being among a sample of 101 participants of Springboard+ programmes at one higher education provider in Dublin. The primary objective of the pilot study is to create and test a research method informed by well validated indicators to inform a larger national study.
Education Service Quality, Value and Satisfaction on Student Customer Intentions and Behaviour
Authors: Prentice Garry , Brady Joseph , McLaughlin Christopher
Published: November 2018

Traditional avenues of accreditation, module review and teaching evaluations are not the only ways to assess education service quality and related issues. In order to evaluate the education service provided by a private university in Ireland, this investigation utilized an extension of Cronin, Brady and Hult’s (2000) model examining the effects of quality, value and customer satisfaction on customer intentions and behaviour. The model predicts that positive perceptions of quality, value and satisfaction in relation to the education service encounter will lead to positive word of mouth, and future intention to use the service again.  The Arts undergraduate student sample size was 260. The perception of a high price for the education service provided did not translate to high service value, and service quality was only shown to have an indirect effect on satisfaction, word of mouth behaviour and intentions to return to the university. Despite a slight majority stating that the service quality was above average, and the majority stating they were satisfied overall, only a minority indicated that they would use the service again. The underlying reasons for and implications from these findings and others are discussed.
The current immigration situation in Great Britain in the context of educational system resources
Authors:   Vladimir State University, Danilova Marina Vladimirovna
Published: November 2018

The study deals with the statistical indicators of the present-day immigration situation in the UK based on the analysis of data from the Office for National Statistics. The research reviews the regional specific nature of the ethnocultural diversity of the country through the prism of school reality and the impact on the resources of local education authorities. The indicators of teaching English as an additional language are characterized. The author identifies the factors associated with the student performance: the detection of special educational needs, switching schools, the implementation of the right to free school meals, the social situation in the area of residence. The emphasis is placed on the difficulties in integrating newcomers into the educational environment, considering the rules and requirements of the British education system caused by both the lack of the period of study and the enrollment of students in the class according to their age regardless of their educational experience. The research presents the personnel resource of the UK education system in relation to work with students being the representatives of ethnic minorities.
The attitude of the population to health (a case of Khabarovsk)
Authors:   Pacific National University, Gutik Tatiana Valeryevna
Published: November 2018

The paper deals with the factors that have a negative impact on human health. The research describes the role of the state and the personality in the preservation of health as well as the state efforts to improve the health of the population. The health-development factors are analyzed, and the role of self-preservation and preventive health behavior is defined. The paper presents the results of a pilot sociological study (Khabarovsk, September-October 2018) conducted by the author to identify the attitude of the population to health. This requires the evaluation of the following indicators: the importance of health, the interest in maintaining one’s health, lifestyle, the responsibility for health, bad habits or the lack of them, the respondents’ activity rate degree of maintaining their physical fitness. The research findings demonstrate the high value of health for people and confirm the relevance of further research into the nature and the impact of life goals on the attitude to their health, the level of literacy and awareness about health risks, the level of health skills, and the health activity rate. The practical significance of the study is to develop a health-activity promotion mechanism for the population that will engage more people in leading a healthy lifestyle and doing sports regularly.
Changes in motives of personal behavior in the context of the scientific and technological revolution
Authors:   Russian University of Transport, Sibgatulina Failya Ravilyevna
Published: November 2018

The study analyzes the changes in personal behavioral motives in the system of social relations of the post-industrial society under the influence of the scientific and technological revolution. The transformation of science into the direct productive force and the development of the educational and cultural level of people in the post-industrial society affect the role and significance of the rational component in people’s behavior. The motive of personal behavior is modified in the context of the scientific and technological revolution. For the motive, the evaluation function turns into a prerequisite for finding ways to meet the needs according to the current level of social production. The predominance of scientific knowledge in the motive structure and the dramatic increase in alternative solutions to the multifactorial problems transform a motivation of personal behavior. For the motivation, the correlation between the sensual and rational components is modified in favor of the latter. The change in human behavioral motive has an impact on the socialization of a person.
ANALYSIS OF SILDENAFIL AND ITS DERIVATIVES IN JAMU (HERBAL MEDICINES) USING LC/MS/MS SPECTROSCOPY
Authors: Kurniaty Rina , Khairan Khairan , Lelifajri Lelifajri
Published: November 2018

Jamu (herbal medicine) is a traditional Indonesian medicine used to nourish, treat, and restore of health, as well as for beauty and fitness. A healthy Jamu is safe when consumed and free from chemicals (in Indonesia it’s called BKO). BKO is a medicinal chemical compound which is intentionally added in jamu (herbal medicine), which aims to increase the accelerate effects of Jamu or herbal medicine from the usual. The aims of this study are to extract, isolate, identify and elucidate the structure of the BKO of sildenafil and it’s derivatives in two herbal preparations circulating in the city of Banda Aceh. Extraction, isolation and identification of sildenafil BKO and its derivatives in jamu were done by using column chromatography (CC) and thin layer chromatography (TLC) meanwhile, the structure elucidation of sildenafil and it’s derivatives were done by Fourier-Transform Infra-Red (FT-IR) and liquid chromatography/mass spectroscopy (LC/MS/MS). The results of extraction, isolation and   identification with a solvent  ethyl acetate: methanol: ammonium hydroxide (25%) (100: 15: 1.5 v/v showed that two jamu circulating in Banda Aceh positively contained BKO sildenafil derivatives, namely thiosildenafil. The FT-IR analysis showed a strong absorption of thiocarbonyl (C=S) group at 1288-1242 cm-1, which is a typical uptake of the thiosildenafil compound. The Spectroscopy LC/MS/MS analysis using electron spray ionization (ESI-MS/MS) showed that the isolate have a similar spectra with thiosildenafil compound [TSLD+H]+ at 491 m/z and [TSLD+Na]+ at 513 m/z and other derivate of thiosildenafil, namely propoxyphenylhydroxylethylthiosildenafil [PHTSLD+H]+ at 533 m/z.
PEMANFAATAN ABU PEMBAKARAN LIMBAH PADAT INDUSTRI CHLOR ALKALI SEBAGAI ADSORBEN PADA PENGOLAHAN LIMBAH CAIRNYA
Authors: Sumingkrat Sumingkrat , Hartini Hartini , Yusuf Adrian
Published: November 2018

Lim bah industri klor alkali termasuk limbah 83 dari sumber yang spesifik. Pembakaran lirnbah padat industri kimia terpadu, yang memproduksi kaustik soda, VCM dan PVC akan menghasilkan abu. Limbah cair media proses polimerisasi PVC setelah pengendapan disebut spent pure water (SPW). Abu sisa pernbakaran, Solid Waste /ncenerator (SWI) ini dapat dimanfaatkan sebagai adsorben  untuk SPW. Sesuai dengan model Freundlich isoterm, SW! mempunyai daya adsorpsi terhadap biru metilen lebih baik dari pada karbon aktif, dan mampu menurunkan turbiditas SPW sampai sekitar 95%.
PROSES KAJIAN TEKNO-EKONOMI KEMUNGKINAN PENDIRIAN INDUSTRI PENGOLAHAN KHITIN DI KOTA MAKASSAR PROPINSI SULAWESI SELATAN
Authors: Sudibyo Agus , Hutajulu Tiurlan F. , Nasyirudin Nasyirudin
Published: November 2018

Kajian tekno-ekonomi kemungkinan pendirian industri pengolahan khitin di Kabupaten Kota Makassar, Propinsi sulawesi Selatan telah dilakukan dengan tujuan untuk mengevaluasi kelayakan pasokan bahan baku, disain proses dan teknologinya, kelayakan finansial dan dampak terhadap ekonominya. Analisis kelayakan pendirian industri khitin ini didasarkan pada dua kapasitas yaitu pertama dengan kapasitas 3 ton kulit udang per hari dan kedua dengan kapasitas 4 ton kulit udang. Hasil analisis kelayakan menunjukkan bahwa industri pengolahan khitin dengan kapasitas 4 ton kulit udang per hari secara finansial layak didirikan di Makassar. Namun industri pengolahan khitin yang erkapasitas 3 ton kulit udang per hari pun secara finansial layak didirikan meskipun nilainya tidak  setinggi industri khitin yang berkapasitas 4 ton kulit udang per hari. Analisis sensitivitas dilakukan pula untuk mengetahui kelayakan industri pengolahan khitin terhadap pengaruh perubahan harga bahan baku, harga bahan kimia pembantu yang dipakai, biaya produksi dan harga khitin. Hasil  analisis sensitivitas menunjukkan bahwa industri pengolahan khitin sangat dipengaruhi atau sensitif terhadap perubahan harga bahan baku, harga bahan kimia pembantu yang dipakai, biaya produksi dan harga jual khitin.
Propriedades geotécnicas de misturas de solo residual de basalto com resíduos de borracha de pneus
Authors: Morais Manuella , Ogliari Bandeira Felipe , Leandro Menegotto Mauro
Published: November 2018

O presente trabalho tem por objetivo avaliar o comportamento hidráulico e mecânico de misturas de um solo argiloso residual de basalto com resíduos de borracha de pneus para utilização em obras geotécnicas. Assim, foram submetidas a ensaios de compactação, permeabilidade e cisalhamento direto, amostras de solo argiloso e de misturas contendo teores de 5%, 10%, 15% e 20% de resíduos de borracha de pneus. Os ensaios de compactação demonstraram que o peso específico seco máximo e o teor de umidade ótimo das misturas apresentam redução com o aumento do teor de resíduo. O coeficiente de permeabilidade mostrou-se crescente com o incremento do resíduo de borracha. Nos ensaios de cisalhamento direto, as misturas apresentaram maior ângulo de atrito interno e menor coesão, quando comparadas ao solo puro. Verificou-se que a utilização dos resíduos de borracha de pneus misturados ao solo deve ser criteriosa, sendo recomendada principalmente como material de enchimento leve ou em obras que possuam critérios de permeabilidade e resistência pouco restritivos.
Modelización numérica de los drenes verticales
Authors: Melentijevic Svetlana , Moreno Robles Javier , Martín Blanco Pablo
Published: November 2018

La instalación de los drenes verticales (columnas de grava y drenes mecha) en terrenos blandos cohesivos es una técnica de mejora del terreno frecuentemente utilizada para la cimentación de los terraplenes. Conjuntamente con aplicación de la precarga permiten acelerar la consolidación del terreno. Este artículo presenta los métodos de la modelización numérica de los drenes verticales, cuyo comportamiento tiene carácter tri-dimensional. Se estudia la evolución de los asientos y disipación de los excesos de las presiones intersticiales durante el proceso de consolidación. Para facilitar los cálculos bi-dimensionales, es necesario transformar el flujo radial correspondiente al dren vertical en términos de una célula unitaria a las condiciones de deformación plana. Adicionalmente en el caso de las columnas de grava se requiere la coincidencia en términos de rigidez. Por ese motivo se requiere la conversión de determinados parámetros geotécnicos necesarios para conseguir la equivalencia en los tiempos de consolidación y de los asientos en los modelos tri-dimensionales y bi-dimensionales. En este artículo se presentan diferentes métodos existentes de transformación de permeabilidades entre la célula unitaria y el modelo en deformación plana, que se pueden conseguir igualando las condiciones de permeabilidad y/o geometría. Se presenta un ejemplo de aplicación contrastando los resultados obtenidos de asientos y disipación de los excesos de presiones intersticiales durante la consolidación. Al final del artículo se presenta un estudio de diferentes mecanismos de rotura de las columnas de grava en función de su posición debajo del terraplén.
Modelação 2.5D MEF-PML de vibrações induzidas em túneis
Authors: Lopes Patrícia , Alves Costa Pedro , Silva Cardoso António , Calçada Rui
Published: November 2018

A simulação e o estudo da problemática das vibrações induzidas pelo tráfego ferroviário em túneis é uma tarefa difícil e complexa. O carácter semi-indefinido do domínio circundante do túnel associado às características tridimensionais do problema são os principais responsáveis pela complexidade do problema. Uma solução eficiente e precisa para a simulação do comportamento dinâmico de estruturas muito longas, como por exemplo, vias férreas ou túneis, é proposta utilizando técnicas 2.5D no contexto do método dos elementos finitos, e adoptando PML’s para o tratamento das fronteiras devido à truncatura do domínio. Dado o recurso a uma abordagem 2.5D MEF-PML não ser usual, as equações do 2.5D PML são derivadas, salientando-se a compatibilidade com o 2.5D MEF. Após essa breve descrição do modelo, exemplos de validação são apresentados, demonstrando a precisão do modelo. Por último, um estudo paramétrico é desenvolvido por forma a avaliar a influência de algumas propriedades do túnel e do solo, nas vibrações induzidas à superfície do maciço.
Pengaruh Proporsi Komisaris Independen, Jumlah Direktur, Jumlah Komite Audit, Kepemilikan Saham Institusional, Kepemilikan Saham Manajemen Dan Ukuran Perusahaan Terhadap Kinerja Keuangan Perusahaan
Authors: Ieneke Santoso Herman Ruslim,
Published: November 2018

This study aims to test the impact ofindependent commissioner, board of directors, audit committee, ownership of institutional and management shares and size of firm to the firm performance of the firms listed at Indonesian Stock Exchange Index LQ45 for two consecutive years of the period  February 2014 to January 2016.  This study use the sampling data of 31 firms  The sampling is based on the method of purposive sampling.  Process of analysis data is carried out with analysis partially first and then analysis simultaneous.  The statistic method used is SPPS ( Statistical Product and Service Solution) to obtain descriptive statistics, correlation of variables and analysis of variance. The result of the partial analysis shows that there are two variable has significant influence to the firm performance which is portion of independent commissioner and ownership of institutional shares.  Whereas, the result of the simultaneous analysis has shows  significant impact.
Memorias de un amor platónico
Authors: Ramírez Claudia
Published: November 2018

"Un día, después de leer Carta al padre de Kafka, decidí hablar sobre mis madres. Así en plural porque aquella cuya sangre pulula por mi cuerpo ya no me reconoce ni mucho menos sabe quién soy. De igual forma hablo sin saber sobre quién lo hago en realidad. Incluso desconozco por qué escribo lo que aquí escribiré".
Carta no enviada
Authors: Fernández Ángel José
Published: November 2018

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La musa secreta
Authors: Sol Mora Pablo
Published: November 2018

"Ambientada a finales del siglo XIX en alguna antigua y venerable ciudad italiana -Roma o Venecia-, esta podría ser una de esas historias de escritores de Henry James. Hay un joven ingenuo en pos de un descubrimiento literario, unas mujeres mayores que ocultan algo, una casona ruinosa y enmohecida y, por supuesto, la sombra omnipresente del poeta muerto. Sin embargo, tuvo lugar en Veracruz, en pleno siglo XX y, lo más importante, no se trata de un relato ficticio."
Ya no están
Authors: López Páez Jorge
Published: November 2018

"Desesperados por mis achaques, mis padres me mandaron con dos tías, hermanas de mi madre, a la capital. Fue en el año de 1930. Paramos en la casa de la tía Otilia, hermana de mi abuelita. Vivía en la calle de Durango, enfrente de la Plaza de Toros. Algún taurófilo podría dar los nombres de los toreros famosos en aquel entonces."
J. Xavier Velasco: el sueño de hacer cine
Authors: Carrillo Finck Fernando
Published: November 2018

"En la escena internacional, el cine mexicano ha logrado el reconocimiento de gran parte de la crítica gracias a trabajos con concepciones renovadas del llamado séptimo arte. Los proyectos que surgen a lo largo del territorio evidencian la pluralidad de propuestas formales que integran la cinematografía nacional. Desde el ámbito xalapeño en particular, la obra de J. Xavier Velasco se presenta como una de las más sólidas, producto de las experiencias profesionales del cineasta."
MEMBANGUN NAGARI FOTOKOPI MELALUI KULIAH KERJA NYATA REVOLUSI MENTAL INDONESIA MELAYANI DI KABUPATEN TANAH DATAR
Authors: Helmizar Helmizar , Putri Aulia Rahmi , Syaputra Ajie
Published: November 2018

Nagari Atar merupakan salah satu nagari yang berada di Kecamatan Padang Ganting Kabupaten Tanah Datar yang memiliki geografis yang berbukit-bukit. Nagari ini dikenal dengan nagari fotokopi yang ditandai dengan adanya tugu fotokopi yang berada di kantor pemerintahan wali nagari. Hampir setengah masyarakat Nagari Atar merantau untuk mencari penghidupan. Dengan banyaknya masyarakat yang merantau sehingga potensi-potensi yang ada di Nagari Atar tidak dapat dimanfaatkan dengan baik, melalui pengabdian ini bertujuan membantu masyarakat untuk mengembangkan potensi-potensi yang ada melalui kegiatan Kuliah Kerja Nyata Revolusi Mental Indonesia Melayani. Metode yang digunakan pada kegiatan ini yaitu pelatihan masyarakat dan difusi IPTEKS berdasarkan permasalahan yang ada sehingga dapat memberikan solusi untuk mengatasi masalah. Dari kegiatan yang telah dilakukan dapat dilihat keberhasilannya dengan banyaknya/antusias masyarakat terhadap kegiatan yang dilakukan. Harapannya hasil dari kegiatan yang dilakukan dapat bermanfaat bagi masyarakat dan mengatasi permasalahan yang ada sehingga Nagari Atar dapat menjadi nagari yang maju.
A case of silent colonic lesions associated with streptococcus gallolyticus, bacteremia and endocarditis
Authors: Berevoescu Nicolae , Bordea Adrian , Scăunașu Răzvan , Berevoescu Mihaela , Cristian Daniel
Published: November 2018

We present a clinical case of synchronous colonic lesions, histologically different, associated with streptococcus gallolyticus subsp. gallolyticus (Sgg)/ Streptococcus bovis biotype I, bacteremia and infective endocarditis. A 53-year-old female, without history of CRC in her family, known with total hysterectomy for uterine fibromatosis, presents to Emergency Department for marked asthenia, nausea, weight loss (10 kgs in the last month), febrile episode associated with severe anemia, symptomatology that has increased in the last two weeks. The patient was admitted in the Internal Medicine Department for further investigations, under the suspicion of sepsis of unknown cause. On blood cultures grew Sgg bacteria. Both transthoracic echocardiography and transesophageal echocardiography were performed and diagnosed infective endocarditis with vegetations of the mitral and aortic valves. Antibiotics treatment was initiated, with ceftriaxone and gentamycin, according to antibiogram results. Severe hypochromic, microcytic anemia, and lack of an infective origin site required digestive endoscopic evaluation, and showed gastritis, ulcerovegetative tumor of the ascending colon and polyp in the rectosigmoid. Resection of rectosigmoid polyp was performed through colonoscopy, and, also, right hemicolectomy with ileo-transverse anastomosis for the ascending colon cancer. Post-operative evolution was favorable. Histological result showed mucinous adenocarcinoma of the ascending colon and tubulovillous adenoma, with moderate dysplasia, in the rectosigmoid. At 6-month, endoscopic evaluation showed normal aspect of anastomosis without presence of other colonic lesions.
Standard or individualized quality of life for larynx cancer patients?
Authors: Ionescu Roxana , Bertesteanu Serban V. , Popescu Radu C. , Balalau Cristian , Scaunasu Razvan V. , Popescu Bogdan
Published: November 2018

Locally advanced larynx cancer benefits from curative surgery therapy. Clinical trials have been proposed for assessing the quality of life for patients with larynx malignant neoplasia who underwent radical surgery. The removal of the “voice box” is known to have great impact on the social reintegration of these patients as well as psychological distress. The presence of tracheostomy and voice impairment are two of the major issues that need to be thought of by patients that will have a total laryngectomy. The quality of life is a multi-dimensional subjective and personal concept which includes normal physical activity, looks, psychological status, somatic symptoms and, non the less, sexual activity. Cancer free survival intervals for patients with larynx cancer must be evaluated physical and psychological modifications with particular considerations to stress, anxiety and depression related symptoms and to functional rehabilitation adaptation regarding swallowing and speech. Oncology surgeons must consider that QoL is impaired in all patients with larynx cancer that benefit from total laryngectomy. However, there is evidence presented below that the difference in QoL parameters is small when comparing radical surgery, total laryngectomy, and larynx conservation by radio and chemotherapy.
A study of community-acquired Mycoplasma pneumoniae in Yantai, China
Authors: Yu Hong Xia , Zhao Mao Mao , Pu Zeng Hui , Ju Yuan Rong , Liu Yan
Published: November 2018

Introduction: Community-acquired pneumonia (CAP) is a global disease responsible for a large number of deaths, with significant economic impact. As diagnostic tools have increased in sensitivity, understanding of the etiology of CAP has begun to change. Mycoplasma pneumoniae is one of the major pathogens causing CAP. Macrolides and related antibiotics are first-line treatments for M. pneumoniae. Macrolide resistance has been spreading for 15 years and now occurs in worldwide. We undertook the first study on macrolide resistance of M. pneumoniae in Yantai. This may be helpful to determine the appropriate therapy for CAP in this population.
Objective: To investigate the rate and mechanism of macrolide resistance in Yantai.
Methods: Pharyngeal swab samples were collected from adult CAP patients. Samples were assayed by polymerase chain reaction (PCR) and cultivated to test for M. pneumoniae. Nested PCR was used to specifically amplify M. pneumoniae 23S rRNA gene fragments containing mutations, and amplicons were analyzed by CE-SSCP for macrolide resistance mutations. Results were confirmed by sequencing. Twenty-seven strains of M. pneumoniae were isolated and the activities of nine antibiotics against M. pneumoniae were tested in vitro.
Results: Out of 128 samples tested, 27 were positive for M. pneumoniae. Mycoplasma 100% macrolides resistance to Mycoplasma pneumoniae. The mechanism of macrolides resistance was A2063G point mutation in the sequence directly binding to macrolides in the 23S rRNA V domain in vitro. The mean pyretolytic time for the fluoroquinolone group was 4.7 ±2.9 d, which was significantly shorter than 8.2 ±4.1 d for the azithromycin group.
Conclusions: Macrolides are not the first-line treatment for M. pneumoniae respiratory tract infections in Yantai.