bluuebunny/crossref_metadata_2025 huggingface dataset:
دراسة حول الترجمات المخطوطة لمعاني القرآن الكريم
Authors: أوغلي أكمل الدين إحسان
Published: November 2022

سوف نركز في هذه الدراسة على المخطوطات الموجودة في الوقت الحاضر، والخاصة بترجمة القرآن الكريم إلى اللغات المختلفة، وسنحاول أيضاتحليل المعطيات الخاصة بميزات هذه المخطوطات وتاريخ ترجمة كل منها، وذلك دون الدخول في أية محاولة لتقييم النصوص المترجمة.
مناهج كتب النوازل الأندلسية والمغربية من منتصف القرن الخامس إلى نهاية القرن التاسع الهجري
Authors: الهيله محمد الحبيب
Published: November 2022

إذا كانت الوظيفة الأساسية لفقهاء المسلمين أن يضعوا أحكاما لكل مايحدث للناس من أقضية في مجتمعاتهم- ضمن إطار العصر الذي يعيشونه،فإنهم يقومون - في نفس الوقت - بوظائف أخرى أهمها: أ) تقديم اجتهادات، وأحكام يمكن أن تستفيد منها الأجيال اللاحقة في ما يعرضلهم من قضايا عصورهم. ب) التصوير الصادق، والحقيقي، للكثير من الواقع المعاش-يقدم للباحثين في التأريخ، والحضارة عناصر تاريخية- لا يرقى إليها شك – تمكنهم من دراسة علمية جادة ونزيهة.
Manuscripts in the history of Makkah and Madīnah
Authors: Al-Jāsir Ḥamad
Published: November 2022

God has favoured the Muslims by His promise to eternally preserve the Book of Islam. ‘We have, without doubt, sent down the Message; and we will assuredly guard it (from corruption)’ (15:9). And it was He who prepared learned men among the Muslims since the time of the Prophet, the blessing of God be upon him, who carried the message of His laws and His commandments and all the tenets of His religion, as they interpreted them from His Holy Book, and as they received them from the Prophet, and transmitted the message faithfully to those whom they deemed worthy of receiving it. And so the message was passed from one age to the next until today.
IT-based smart-university driven management of higher education training activities
Authors:   Information Technology Center, Cyber School, Vinh University, Vietnam, Van Tan LE
Published: November 2022

The IT-based management of training activities at universities has many inadequacies. According to the facilitation of comprehensive IT system application under digital transformation in education sector with the aim of smart-university driven model application, this paper provides a systematic view of a smart university, and analyses some issues related to IT-based training management, which supports Vietnamese universities to integrate smart-university driven management systems.
PROFIL HEDONIK KEMPLANG PANGGANG KHAS PALEMBANG
Authors: Nafsiyah Ikromatun , Seftylia Diachanty  , Selly Ratna Sar  , Guttifera  , Rani Ria Rizki  , Lestari Siti , Nanda Syukerti
Published: November 2022

Palembang's kemplang panggang is one of Palembang's original foods that is populer both inside and outside of Palembang. Kemplang is widely sold and produced in Palembang. The number of baked kemplang products makes consumers confused in choosing baked kemplang products which later became the basis for this research. This study was purposed to determine the level of consumer/panelist preference for baked kemplang sold in markets around Palembang. Kemplang Panggang Palembang of this study was purchased from three different markets and different trade names. This study was divided into two stages, namely the preparation stage and the implementation stage of hedonic testing carried out by 25 semi-trained panelists with four parameters such as aroma, color, taste, and texture. The highest results on the parameters of aroma, color, taste, and texture were found in the sample with code 303 with a “like” level. Based on these results, it can be concluded that sample 303 is the most preferred baked kemplang compared to other baked kemplang samples
Pemanfaatan Jeroan Ikan Dengan Limbah Kulit Jagung Sebagai Pakan Alternatif Ikan Lele
Authors: Ion Tarsardo Sianturi  , Fajar Panuntun  , Fransiska Indang
Published: November 2022

The demand for freshwater consumption fish, especially catfish, is so fast that the aquaculture sector needs to be increased again. The supporting factor in the success of aquaculture is feed, where feed for catfish cultivation on Timor Island, NTT is still much more expensive than on the island of Java, this is an inhibiting factor for the success of cultivation on Timor Island. These problems can be overcome by making independent feed. The purpose of this activity is to determine the potential of local raw materials or waste in Timor Island as raw materials for making fish feed. The method used is a descriptive method where research describes the phenomenon or individual characteristics, the situation accurately in a certain group. Based on the results obtained that the waste on the island of Timor, namely fish offal and corn husks can be used as raw materials for making feed and has a fairly good buoyancy shown by being able to float for more than 5 minutes.
Emisores de Valores y Gobierno Corporativo
Authors: Trujillo Dávila María Andrea , Guzmán Vásquez Alexander
Published: November 2022

El propósito de esta publicación es dar a conocer y analizar la evolución en las prácticas de gobierno corporativo en los emisores de valores en Colombia, tomando como fuente principal para este análisis la información reportada por las empresas en el diligenciamiento de la encuesta de mejores prácticas corporativas, más conocida como encuesta Código País, para el periodo 2007-2014, dando cumplimiento a la Circular Externa 028 de 2007 de la Superintendencia Financiera de Colombia. La encuesta pretende realizar un seguimiento al nivel de implementación de las recomendaciones de adopción voluntaria incluidas en el Código de Mejores Prácticas Corporativas de Colombia, conocido como Código País, contenido en el Anexo 2 de la circular en mención. El texto incluye 41 recomendaciones en materia de: (i) Asamblea General de Accionistas (11 recomendaciones), (ii) Junta Directiva (15 recomendaciones), (iii) Revelación de Información Financiera y No Financiera (13 recomendaciones), y (iv) Solución de Controversias (2 recomendaciones). En el cumplimiento del propósito de la publicación, se analizan los códigos de gobierno corporativo (soft law) a nivel país y se realiza un comparativo frente a otras alternativas como la regulación (hard law), o los modelos híbridos, como el Segmento Novo Mercado, en Bovespa, Brasil o el Programa IR, de la BVC en Colombia. Luego se discute la adopción de las recomendaciones del Código País por parte de todos los emisores en Colombia. Para el efecto se analizan 1,303 encuestas. Los resultados generales muestras una tasa de adopción baja en comparación con las experiencias internacionales, que empieza en el 2007 en 45.9% y termina en el 2014 en 65.6%. Los resultados además muestran que las empresas tienen menores tasas de adhesión al código en las recomendaciones de junta directiva y de información financiera y no financiera.
HUBUNGAN SPIRITUAL LEADERSHIP DENGAN KINERJA PERAWAT DALAM MELAKSANAKAN ASUHAN KEPERAWATAN
Authors: Silvia Dewi Mayasari Riu  , Faradilla Miftah Suranata
Published: November 2022

Introduction. Leadership is a very decisive factor in the success of an organization. Spiritual leadership that is applied at the hospital are believed to be capable of evoking motivation of nurses can further improve the implementation of nursing care. The purpose of this research is to know the relationship of Spiritual Leadership With the nurse Performance in performing Nursing Care. Research methods. done using penilitian Type used is Descriptive Analytic with Crossectional draft. The sample numbered 36 respondents using Simple Random Sampling techniques. Data collection is done by distributing questionnaires and observation sheets. Furthermore the data that has been collected is processed using computer-assisted program SPSS version 16.0 for analysis by using the chi square statistic test with significance level (α) 0.05. The results. in this study, there is a Spiritual Relationship With the nurse Performance Leadership In Implementing Nursing Care. Obtained p = the value of 0,018 showed < α = 0.05. The discussion. The results of this study expect can add information that can be used to improve the performance of the nurses in the care of nursing.
PERILAKU DALAM PELAKSANAAN PROGRAM GERAKAN MASYARAKAT HIDUP SEHAT (GERMAS) DENGAN KEJADIAN PENYAKIT HIPERTENSI DI PUSKESMAS WORI
Authors: Kristine Dareda  , Berthalina H. Korah
Published: November 2022

Berdasarkan data sekunder, penyakit hipertensi mengalami peningkatan setiap tahunnya. Survey awal yang dilakukan di Puskesmas Wori bulan oktober ada 27 kasus hipertensi dan meningkat pada bulan November sebanyak 115 kasus hipertensi. Tujuan penelitian ini untuk mengetahui Hubungan perilaku keluarga dalam program gerakan masyarakat hidup sehat (GERMAS) dengan penyakit hipertensi di Puskesmas Wori. Metode yang digunakan yaitu deskriptif analitik bersifat Cros Sectional. Sampel dalam penelitian ini yaitu 30 responden dengan teknik pengambilan sampel Accidental Sampling. Data dikumpulkan menggunakan kuisioner dan lembar observasi, selanjutnya diolah menggunakan SPSS dengan uji statistic Continuity Correction. Hasil dalam penelitian didapatkan nilai ρ = 0,001 dengan tingkat kemaknaan (α) = 0,05 artinya terdapat hubungan antara perilaku dalam pelaksanaan program germas dengan kejadian penyakit hipertensi di Puskesmas Wori. Kesimpulan yaitu Sebagian besar lansia di Puskesmas Wori memiliki perilaku dalam pelaksanaan GERMAS yang kurang baik. Sebagian besar lansia di Puskesmas Wori memiliki penyakit hipertensi. Disarankan agar program Germas dapat ditingkatkan di Puskesmas Wori.
Faktor - Faktor Yang Berhubungan Dengan Keikutsertaan Suami Dalam KB Vasektomi Di Kel.Pandu Kec.Bunaken Kota Manado
Authors: Noormah Juwita  , Ria A.J.Rotinsulu
Published: November 2022

Rendahnya keikutsertaan suami dalam program KB berhubungan dengan beberapa faktor yaitu pengetahuan,umur,jumlah anak serta dukungan pada keluarga.  Dan masyarakat yang masih menggangap keikutsertaan belum atau tidak penting dilakukan. Bila dibandingkan dengan partisipasi pria di negara-negara tetangga seperti : Korea (27%), Sri Langka (26%), Filipina (24%), Bangladesh (18%), Nepal (18%), Malaysia (16,8%), Cina (11%), Thailand (9%), dan Pakistan (9%),  maka Indonesia menempati angka paling rendah keikutsertaan dalam ber-KB.Tujuan penelitian ini Untuk mengidentifikasi faktor yang berhubungan ; pengetahuan, umur, jumlah anak dan dukungan keluarga dengan keikutsertaan suami dalam KB vasektomi di Kel.Pandu Kec.Bunaken Kota Manado

Penelitian ini merupakan penelitian kuantitatif menggunakan rancangan cross sectional. Jumlah sampel yang di ambil adalah 150 orang suami  Di Kel. Pandu Kec. Bunaken Kota Manado. Instrument penelitian yang digunakan adalah kuesioner. Analisis data meliputi analisis univariat menggunakan distribusi frekuensi dan analisis bivariat menggunakan uji chi square.

Berdasarkan hasil penelitian adalah pengetahuan sebagian besar memiliki pengetahuan cukup yakni 72 responden ( 48 % ) , sebagian besar memiliki umur < 30 - 40 Tahun yakni 77 responden (51,3 %), jumlah anak hampir seluruhnya memiliki jumlah anak hidup > 2 Org yakni  81 responden (54 %). Kesimpulan dari penelitian ini adalah ada hubungan umur dengan keikutsertaan suami KB vasektomi sedangkan  tidak ada hubungan yang bermakna antara pengetahuan dan jumlah anak.
PEMBERDAYAAN KADER KESEHATAN DALAM PELAKSANAAN DETEKSI DINI GANGGUAN TUMBUH KEMBANG ANAK DI DESA PALAES KECAMATAN LIKUPANG BARAT KABUPATEN MINAHASA UTARA
Authors: Cut Mutiya Bunsal  , Rizal Arsyad
Published: November 2022

Tumbuh kembang anak merupakan suatu proses yang kontinyu, dimulai sejak kandungan sampai anak tumbuh dewasa. Kualitas anak yang baik dapat dicapai dengan memastikan bahwa proses tumbuh kembang anak juga baik. Pemantauan pertumbuhan, perkembangan, dan gangguan tumbuh kembang anak merupakan acuan bagi tenaga kesehatan yang bekerja pada fasilitas pelayanan kesehatan dasar/primer. Pengabdian kepada masyarakat dilakukan kepada kader kesehatan di desa Palaes yang berjumlah 6 orang dengan kegiatan pemberian materi tentang DDTK dan dilakukan simulasi deteksi dini tumbuh kembang anak. Adapun keberadaan kader kesehatan dapat menunjang kinerja puskesmas dalam mendeteksi gangguan tumbuh kembang anak. Pemberdayaan dilakukan kepada kader kesehatan yang ada agar kinerja dapat deteksi dini tumbuh kembang anak dapat maksimal dilakukan dipelayanan posyandu dengan keterlibatan yang dilakukan langsung oleh kader kesehatan desa.
Revolution und Resilienz: Die ukrainische Zivilgesellschaft und das Ende des Post- Sowjetismus
Authors: Worschech Susann
Published: November 2022

Seit dem Beginn des russischen Angriffskriegs auf die gesamte Ukraine im Februar 2022 ist vielfach von der Resilienz der ukrainischen Gesellschaft die Rede, deren Wurzeln in diesem Text analysiert werden sollen. Die Entwicklung der ukrainischen Zivilgesellschaft ist einerseits von einer langen Protesthistorie geprägt, die bis zur Staatsgründung im frühen 20. Jahrhundert zurückreicht. Andererseits lassen sich verschiedene Revolutionszyklen und Verdichtungspunkte seit der ukrainischen Unabhängigkeit identifizieren, in denen sich spezifische Handlungsrepertoires und Organisationsformen der ukrainischen Zivilgesellschaft herausbildeten. Die außergewöhnliche und wohl auch unerwartete Resilienz der Ukraine gegenüber der russischen Invasion wurzelt, so die These dieses Aufsatzes, in der Entwicklung der ukrainischen Zivilgesellschaft von der Protestgesellschaft zur „aktiven“ und breit engagierten Gesellschaft.
Digital study of interocclusal contact points in patients with partial
tooth loss in case of immediate and nearest implantation prosthetics
Authors: Alpatieva Yulia , Bulycheva Elena , Konchakovsky A.
Published: November 2022

The main purpose of this study was to study the qualitative and quantitative characteristics of occlusal ratios of dentitions in patients with partial loss of teeth replaced by preliminary direct or proximal dental implantsprostheses to prevent complications on the masticatory muscles and the temporomandibular joint.
The article presents a detailed analysis of the interocclusal relations of dentitions in patients with partial tooth loss before and after prosthetics, including an assessment of the interocclusal contact points, their multiplicity, uniformity and strength of masticatory pressure, the presence of premature contacts, the trajectory of the overall direction
of occlusal load, occlusal balance between the left and the right sides of dentition. The assessment of interocclusal relationships in the control and main groups was carried out using an available, simple, and unbiased digital device "T-Scan III" (Tekscan, USA).
OSTROŁĘCKO - SIEDLECKI SUBREGION IN THE IDEA OF SUSTAINABLE DEVELOPEMENT IN MAZOWIECKIE PROVINCE
Authors: Rakowski Witold
Published: November 2022

In view of the fact that one of the objective of development strategy in Mazowieckie Province is to redeem the difference betwen the subregion in the range of economic and social developement, the author proves, by using selected indiacators, that theidea of sustainable developement in Mazowieckie Province is not realized. In the years 1999 - 2007 the differences have deepened in the level of developement between ostrołęcko - siedlecki subregion and Warsaw.
Attitudes of sports coaches toward deafness as an indicator of creating an inclusive climate
Authors: Karić Jasmina , Kordić Milena
Published: November 2022

Introduction. An inclusive approach to sports means opening up opportunities for deaf people to participate in sports activities equally to the hearing population. The paper deals with attitudes toward deafness from the perspective of sports coaches, who represent an important factor in creating an inclusive sports environment. Objectives. The aim of this research was to determine the orientation of sports coaches' attitudes toward deafness. As part of the research tasks, attitudes were examined in relation to age, gender, level of education and the type of sport the coaches practice. Methods. The research was conducted on a sample of 39 participants within the population of sports coaches. The sample consisted mostly of male subjects (66.7 %) 24 to 60 years of age, with the average age being 30.8 (SD = 7.61). Most participants completed undergraduate academic studies (43.6%). The majority of the sample were team sports coaches (82.1%). The Attitudes to Deafness Scale was used as an instrument. Results. The results showed that sports coaches were neutral in their attitudes toward deafness. Age, gender, level of education, and the type of sport did not appear to be significant factors in their attitudes toward deafness. Conclusion. Future research can focus on tests that will test the presence and influence of joint contact between sports coaches and deaf people on their attitudes toward deafness. The dominance of neutral and negative attitudes potentially represents an obstacle to the social inclusion of the deaf through sports and challenges experts dealing with the deaf population to subtly influence the change of attitudes of sports coaches toward deafness in adequate ways.
Recent advances in surveillance colonoscopy for dysplasia in inflammatory bowel disease
Authors: Na Soo-Young , Moon Won
Published: November 2022

Inflammatory bowel disease (IBD) has a global presence with rapidly increasing incidence and prevalence. Patients with IBD including those with ulcerative colitis and Crohn’s disease have a higher risk of developing colorectal cancer (CRC) compared to the general population. Risk factors for CRC in patients with IBD include long disease duration, extensive colitis, primary sclerosing cholangitis, family history of CRC, stricture, and prior dysplasia. Surveillance colonoscopy for CRC in patients with IBD should be tailored to individualized risk factors and requires careful monitoring every year to every five years. The current surveillance techniques are based on several guidelines. Chromoendoscopy with targeted biopsy is being recommended increasingly, and high-definition colonoscopy is gradually replacing standard-definition colonoscopy. However, it remains unclear whether chromoendoscopy, virtual chromoendoscopy, or white-light endoscopy has better efficiency when a high-definition scope is used. With the development of new endoscopic instruments and techniques, the paradigm of surveillance strategy has gradually changed. In this review, we discuss cutting-edge surveillance colonoscopy in patients with IBD including a review of literature.
FACTORS AFFECTING THE SUSTAINABILITY OF LEAN IN HEALTHCARE: A SYSTEMATIC LITERATURE REVIEW
Authors: Wagner Reginal , Hattingh Teresa , Meijer Hanneke
Published: November 2022

The application of Lean in healthcare has been steadily climbing since 2000. However, Lean implementation in healthcare environments has experienced high failure rates that could be attributed to a lack of sustainable implementation. A knowledge gap has therefore been identified, in both practice and research, to understand the reason for failure and the impact of Lean sustainability on Lean success. The aim of the main study is to explore the factors that affect the sustainability of Lean healthcare in South African hospitals. This paper reports on the first part of the study, a systematic literature review (SLR) that identifies the factors that affect the sustainability of Lean healthcare in hospitals. Through the SLR, 50 factors affecting Lean sustainability in hospitals were identified and grouped into 12 themes. These themes were then tested against Lean principles. The results showed that the adaptation of Lean so that it makes sense to healthcare staff and is compatible with a hospital context is important for sustainability. Staff and organisational readiness during Lean implementation is also critical for long-term sustainability. The SLR results will be used to develop an interview protocol for the second part of the main study, which will involve interviews with South African-based practitioners, consultants, and academics who are directly involved in Lean implementation in South African hospitals. Keywords Lean; Lean healthcare; Lean principles; factors; systematic literature review; hospital
CAGE20-4 Cruise Report: High-resolution 2D and 3D seismic investigations on the Møre and Vøring Margins
Authors: Bünz Stefan
Published: November 2022

The CAGE20-4 expedition on RV Helmer Hanssen targeted areas on the outer margins of the Møre and Vøring basins, with emphasis on IODP drilling proposal P944 sites. High-resolution 2D and 3D P-Cable seismic studies focused in particular on the structure of igneous deposits and how tectonic and igneous events have affected the Paleogene and global climate through gas production from organic-rich sediments and release into the atmosphere via hydrothermal venting. This expedition was part of a collaboration between CAGE and the Center for Earth Evolution and Dynamics (CEED) at the University of Oslo.

The cruise may be known as: CAGE20_4
How does serif vs sans serif typeface impact the usability of e-commerce websites?
Authors: Vecino Sara , Mehtali Jonas , de Andrés Javier , Gonzalez-Rodriguez Martin , Fernandez-Lanvin Daniel
Published: November 2022

This study tries to find evidence that points towards the best typeface to use in e-commerce websites to maximize usability, trust, loyalty, appearance and overall user satisfaction. We tested the difference between serif and sans serif inside the same font family. A total of 246 volunteers participating in the experiment were asked to complete a set of tasks and a questionnaire on an e-commerce website prototype. We measured task completion time, reading speed and reading comprehension. From the results, using multiple linear regression, we deduced that only gender determines user preferences. Females tend to prefer the serif version of the typeface under study. Although most e-commerce websites use sans serif typefaces, we could not find evidence supporting this decision. The serif and sans serif characteristic inside the same font family does not affect usability on a website, as it was found that it has no impact on reading speed and user preference.
Dynamic analysis of the microbial communities and metabolome of healthy banana rhizosphere soil during one growth cycle
Authors: Ye Liujian , Wang Xiaohu , Wei Shengbo , Zhu Qixia , He Shuang , Zhou Liqin
Published: November 2022

Background

The banana-growing rhizosphere soil ecosystem is very complex and consists of an entangled network of interactions between banana plants, microbes and soil, so identifying key components in banana production is difficult. Most of the previous studies on these interactions ignore the role of the banana plant. At present, there is no research on the the micro-ecological environment of the banana planting growth cycle.

Methods

Based on high-throughput sequencing technology and metabolomics technology, this study analyzed the rhizosphere soil microbial community and metabolic dynamics of healthy banana plants during one growth cycle.

Results

Assessing the microbial community composition of healthy banana rhizosphere soil, we found that the bacteria with the highest levels were Proteobacteria, Chloroflexi, and Acidobacteria, and the dominant fungi were Ascomycota, Basidiomycota, and Mortierellomycota. The metabolite profile of healthy banana rhizosphere soil showed that sugars, lipids and organic acids were the most abundant, accounting for about 50% of the total metabolites. The correlation network between fungi and metabolites was more complex than that of bacteria and metabolites. In a soil environment with acidic pH, bacterial genera showed a significant negative correlation with pH value, while fungal genera showed no significant negative correlation with pH value. The network interactions between bacteria, between fungi, and between bacteria and fungi were all positively correlated.

Conclusions

Healthy banana rhizosphere soil not only has a stable micro-ecology, but also has stable metabolic characteristics. The microorganisms in healthy banana rhizosphere soil have mutually beneficial rather than competitive relationships.
A klímaváltozás hatásának modellezése a főbb hazai gabonafélék esetében
Authors: Bene Enikő , Domán Csaba , Keményné Horváth Zsuzsanna , Lőrincz Katalin , Vári Enikő , Vígh Enikő , Zubor-Nemes Anna
Published: November 2022

Az üvegházhatású gázok kibocsátásának csökkentése, illetve azok negatív hatásaihoz történő alkalmazkodás hiányában, a globális és regionális klímaszcenáriók előrejelzése alapján (amelyek jelentős szórást mutatnak) a mezőgazdasági termelés környezeti feltételeinek további romlása várható. Mindez jól megalapozott felkészülést tesz szükségessé az agrárágazat szereplői részéről. Ehhez szükséges számszerűsíteni a lehetséges beavatkozások következményxeit, azok hozamokra, költségekre és jövedelmezőségre gyakorolt hatását. Jelen kutatás a hatékony alkalmazkodás szempontjából kiemelkedően fontos, országosan reprezentatív, valós üzemi szintű (mikrogazdasági) agromenedzsment adatokra alapozott szimulációs hatásvizsgálatot dokumentál. Több regionális klímamodell szimulációs eredményének figyelembevétele alapján – azok bizonytalansága mellett – a jelenlegi agrotechnika alkalmazása mellett a búza hozamának kisebb, míg a kukorica hozamának nagyobb mértékű csökkenése várható. A szimulációk eredménye szintén rámutat az egyes beavatkozások időpontjának változására, a tenyészidőszak eltolódására. Az őszibúza esetében, az általunk vizsgált alkalmazkodási lehetőségek (intenzívebb tápanyaggazdálkodás, öntözés) átlagosan nem tudták kompenzálni a klímaváltozás negatív hatását. Ugyanakkor a kukorica esetében az öntözés és az ehhez kapcsolódó megnövelt műtrágya felhasználás számottevően javítja az adaptáció eredményét: 2050-ig akár még hozamnövekedés is elképzelhető (+10 százalék a jelenlegi színvonalhoz képest), 2100-ig pedig csak 7 százalékkal csökkennek a hozamok a pótlólagos víz kijuttatásával (szemben az adaptáció nélkül várható 28%-os csökkenéssel). Fontos azonban hangsúlyozni, hogy a kukorica esetében adaptációval várhatóan elérhető, hozamokban kifejezett pozitív hatás nem került kifejezésre költségek és többletbevétel tekintetében. Ennek hiányában az adaptációs stratégiák gazdasági életképessége pillanatnyilag nem értékelhető.
Who's listening?
Authors: Atwool Nicola
Published: November 2022

This paper outlines ways in which traumatised children remain invisible and argues that play is one means of giving children a voice in the therapeutic environment. It begins with a discussion of the ways in which children's trauma often remains invisible. It outlines briefly the impact of trauma and offers an alternate construction to the dominant discourse, arguing that each child's experience is unique and that his/her voice must be heard at each stage of the process if therapy is to be effective. The relevance of play in therapeutic work with children is then discussed, drawing on research and clinical experience to illustrate the significance of play in giving children a voice and achieving positive therapeutic outcomes. In the final section, the implications for adults' interaction with children in other contexts is outlined and the implications for adult psychotherapy are also explored.
Tumor Cell‐Responsive Photodynamic Immunoagent for Immunogenicity‐Enhanced Orthotopic and Remote Tumor Therapy
Authors: Chen Yingchao , Xiong Tao , Zhao Xueze , Du Jianjun , Sun Wen , Fan Jiangli , Peng Xiaojun
Published: November 2022

Combining photodynamic therapy (PDT) and immune checkpoint blockades is an efficient method to maximize immunotherapeutic outcome by boosting tumor immunogenicity and modulating the immunosuppressive tumor microenvironment. However, the always‐on bioactivity of photosensitizers or immune checkpoint inhibitors leads to uncontrollable side effects, limiting the in vivo therapeutic efficacy of treatments. An activatable strategy is of great importance for improving the selectivity during cancer therapy. In this study, a photodynamic immunomodulator, ICy‐NLG, is developed by conjugating the photosensitizer ICy‐NH2 with the indoleamine 2,3‐dioxygenase 1 inhibitor NLG919 through a glutathione (GSH)‐cleavable linker to achieve activatable photodynamic immunotherapy. The conjugation considerably suppresses both the PDT effect and the activity of the inhibitor. After ICy‐NLG is activated by high levels of GSH in tumor cells, the PDT effect is restored and leads to immunogenic tumor cell death. The released tumor‐associated antigens in conjunction with the activated immune checkpoint inhibitor induce a synergistic antitumor immune response, resulting in the growth inhibition of primary and distant tumors and the prevention of lung metastasis in mouse xenograft models.
Dual “Unlocking” Strategy to Overcome Inefficient Nanomedicine Delivery and Tumor Hypoxia for Enhanced Photodynamic‐Immunotherapy
Authors: Li Xianglong , Jiang Cong , Jia Xinlin , Cao Yuanyuan , Mao Yuanqing , Hao Ji‐Na , Yang Yang , Zhang Peng , Li Yongsheng
Published: November 2022

Lacking blood vessels is one of the main characteristics of most solid tumors due to their rapid and unrestricted growth, which thus causes the inefficient delivery efficiency of nanomedicine and tumor hypoxia. Herein, a dual “unlocking” strategy to overcome these obstacles is proposed by combining engineered hybrid nanoparticles (named ZnPc@FOM‐Pt) with dexamethasone (DXM). It is verified that pretreatment of tumors with DXM can increase intratumorally micro‐vessel density (delivery “unlocking”) to enhance the tumor delivery efficiency of ZnPc@FOM‐Pt and decrease HIF‐1α expression. Correspondingly, more Pt can catalyze tumor‐overexpressed H2O2 to produce oxygen to further cause hypoxia “unlocking,” ultimately achieving boosted ZnPc‐based photodynamic therapy in vivo (tumor inhibition rate: 99.1%). Moreover, the immunosuppressive tumor microenvironment is efficiently reversed and the therapeutic effect of anti‐PD‐L1‐based immunotherapy is promoted by this newly designed nanomedicine. This dual “unlocking” strategy provides an innovative paradigm on simultaneously enhancing nanomedicine delivery efficacy and hypoxia relief for tumor therapy.
Local Characterization of Field Emission Properties of Graphene Flowers
Authors: Giubileo Filippo , Capista Daniele , Faella Enver , Pelella Aniello , Kim Woo Young , Benassi Paola , Passacantando Maurizio , Di Bartolomeo Antonio
Published: November 2022

An experimental study about field emission properties of commercially available graphene flowers cloth is reported. Material characterization by means of X‐ray diffraction, Raman spectroscopy, and X‐ray photoemission spectroscopy confirms the formation of high quality vertical few‐layers graphene nanosheets. A tip‐anode setup is exploited in which nanomanipulated tungsten tip is used as the anode at controlled distance from the emitter in order to reduce the effective emitting area below 1 µm2, giving access to local characterization. A turn‐on field as low as 0.07 V nm−1 and field enhancement factor up to 32 for very small cathode–anode separation distances is demonstrated, in the range 400–700 nm. It is also shown that the turn‐on field increases for increasing distances, while the field enhancement factor decreases. Finally, time stability of the field emission current is reported, evidencing a reduction of the fluctuations for lower current levels.
Large‐Scale Ultrathin Channel Nanosheet‐Stacked CFET Based on CVD 1L MoS2/WSe2
Authors: Liu Menggan , Niu Jiebin , Yang Guanhua , Chen Kaifei , Lu Wendong , Liao Fuxi , Lu Congyan , Lu Nianduan , Li Ling
Published: November 2022

Nanosheet (NS) vertical‐stacked complementary field‐effect transistors (CFETs), where the NS n‐FET and NS p‐FET are vertically stacked and controlled using a common gate, would result in maximum device footprint reduction. However, silicon‐based transistor will become invalid due to mobility degradation and leakage current rising when scaling the thickness of channel and dielectric. Here, it is experimentally demonstrated that CFET can scaling down to 1 nm channel thickness with excellent performance, where chemical vapor deposition (CVD) one layer (1L) WSe2p‐type NS FET is vertically stacked on top of CVD 1L MoS2n‐type NS FET. Bottom MoS2NS FET achieves high on‐state current ofION = 3.3 × 10−5A µm µm−1and low off‐state current ofIOFF = 3.3 × 10−13A µm µm−1atVDS = 0.7 V, with the subthreshold swing reaching 80 mV dec−1. Top WSe2NS FET achieves high on‐state current ofION = 1.2 × 10−5A µm µm−1andIOFF = 4 × 10−11A µm µm−1atVDS = −0.7 V, while the subthreshold swing reaching 150 mV dec−1. Statistical data of 22 CFET devices demonstrate excellent uniformity toward large‐area applications. The CFET based on large‐scale 2D materials breaks the limit of channel scaling and provides a technological base for future high‐performance and low‐power electronics.
Nonvolatile Electrochemical Random‐Access Memory under Short Circuit
Authors: Kim Diana S. , Watkins Virgil J. , Cline Laszlo A. , Li Jingxian , Sun Kai , Sugar Joshua D. , Fuller Elliot J. , Talin A. Alec , Li Yiyang
Published: November 2022

Electrochemical random‐access memory (ECRAM) is a recently developed and highly promising analog resistive memory element for in‐memory computing. One longstanding challenge of ECRAM is attaining retention time beyond a few hours. This short retention has precluded ECRAM from being considered for inference classification in deep neural networks, which is likely the largest opportunity for in‐memory computing. In this work, an ECRAM cell with orders of magnitude longer retention than previously achieved is developed, and which is anticipated to exceed ten years at 85 °C. This study hypothesizes that the origin of this exceptional retention is phase separation, which enables the formation of multiple effectively equilibrium resistance states. This work highlights the promises and opportunities to use phase separation to yield ECRAM cells with exceptionally long, and potentially permanent, retention times.
Synthesis of Fully Substituted Sumanenes at the Aromatic Periphery through Hexabromomethylation
Authors: Nakazawa Hironobu , Uetake Yuta , Yakiyama Yumi , Sakurai Hidehiro
Published: November 2022

2,3,5,6,8,9‐Hexakis(bromomethyl)sumanene, a hexa‐substituted sumanene with bromomethyl groups at the peripheral aromatic carbons, was successfully synthesized in 97% yield with a one‐step reaction. Single‐crystal X‐ray structural analysis showed a formation of a dimer structure. The nucleophilic substitution afforded the introduction of several substituents. These UV‐vis absorption and emission spectra showed clear redshift compared with pristine sumanene, indicating the extension of the conjugation system of hexa‐substituted sumanenes.
The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation
Authors: Dong Yinping , Zhang YuanYang , Wang Xinyue , Li Wenxuan , Zhang Junling , Lu Lu , Dong Hui , Fan Saijun , Meng Aimin , Li Deguan
Published: November 2022

Background

Gastrointestinal (GI) injury is one of the most common side effects of radiotherapy. However, there is no ideal therapy method except for symptomatic treatment in the clinic. Xuebijing (XBJ) is a traditional Chinese medicine, used to treat sepsis by injection. In this study, the protective effects of XBJ on radiation‐induced intestinal injury (RIII) and its mechanism were explored.

Methods

The effect of XBJ on survival of irradiated C57BL/6 mice was monitored. Histological changes including the number of crypts and the length of villi were evaluated by H&E. The expression of Lgr5+ intestinal stem cells (ISCs), Ki67+ cells, villin and lysozymes were examined by immunohistochemistry. The expression of cytokines in the intestinal crypt was detected by RT‐PCR. DNA damage and apoptosis rates in the small intestine were also evaluated by immunofluorescence.

Results

In the present study, XBJ improved the survival rate of the mice after 8.0 and 9.0 Gy total body irradiation (TBI). XBJ attenuated structural damage of the small intestine, maintained regenerative ability and promoted proliferation and differentiation of crypt cells, decreased apoptosis rate and reduced DNA damage in the intestine. Elevation of IL‐6 and TNF‐α was limited, but IL‐1, TNF‐𝛽 and IL‐10 levels were increased in XBJ‐treated group after irradiation. The expression of Bax and p53 were decreased after XBJ treatment.

Conclusions

Taken together, XBJ provides a protective effect on RIII by inhibiting inflammation and blocking p53‐related apoptosis pathway.
Fine Pore‐Structure Engineering by Ligand Conformational Control of Naphthalene Diimide‐Based Semiconducting Porous Coordination Polymers for Efficient Chemiresistive Gas Sensing
Authors: Xue Ziqian , Zheng Jia‐Jia , Nishiyama Yusuke , Yao Ming‐Shui , Aoyama Yoshitaka , Fan Zeyu , Wang Ping , Kajiwara Takashi , Kubota Yoshiki , Horike Satoshi , Otake Ken‐ichi , Kitagawa Susumu
Published: November 2022

Exploring new porous coordination polymers (PCPs) that have tunable structure and conductivity is attractive but remains challenging. Herein, fine pore structure engineering by ligand conformation control of naphthalene diimide (NDI)‐based semiconducting PCPs with π stacking‐dependent conductivity tunability is achieved. The π stacking distances and ligand conformation in these isoreticular PCPs were modulated by employing metal centers with different coordination geometries. As a result, three conjugated PCPs (Co−pyNDI, Ni−pyNDI, and Zn−pyNDI) with varying pore structure and conductivity were obtained. Their crystal structures were determined by three‐dimensional electron diffraction. The through‐space charge transfer and tunable pore structure in these PCPs result in modulated selectivity and sensitivity in gas sensing. Zn−pyNDI can serve as a room‐temperature operable chemiresistive sensor selective to acetone.
NMR and DFT Studies with a Doubly Labelled15N/6LiS‐Trifluoromethyl Sulfoximine Reveal Why a Directedortho‐Lithiation Requires an Excess ofn‐BuLi
Authors: Hédouin Matthieu , Barthelemy Anne‐Laure , Vanthuyne Nicolas , Besrour Hend , Maddaluno Jacques , Magnier Emmanuel , Oulyadi Hassan
Published: November 2022

This work shows why it is imperious to use an excess of butyllithium for a directedortho‐lithiation of a trifluoromethyl sulfoximine. The analysis of mixtures ofn‐BuLi and sulfoximine1in THF‐d8using {1H,6Li,13C,15N,19F} NMR experiments at low temperatures reveal that a first deprotonation occurs that leads to dimeric and tetrameric N‐lithiated sulfoximine (93 : 7). Using an excessn‐BuLi (5 equivalents), the second deprotonation on theortho‐position of the aromatic occurs. Six species were observed and characterized on the way. It includes three aggregates involving a sulfoximine: i) a [dilithiated sulfoximine/(n‐BuLi)] dimer solvated by four molecules of THF (Agg2, 39 %); ii) a [dilithiated sulfoximine/(n‐BuLi)3] tetramer solvated by six molecules of THF (Agg3, 39 %); iii) a [dilithiated sulfoximine/(n‐BuOLi)3] tetramer solvated by four molecules of THF (Agg1, 22 %). A DFT study afforded optimized solvated structures for all these aggregates, fully consistent with the NMR data.
Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor‐Mediated Bioorthogonal Activation Approach
Authors: Chu Jacky C. H. , Wong Clarence T. T. , Ng Dennis K. P.
Published: November 2022

Targeted delivery and specific activation of photosensitizers can greatly improve the treatment outcome of photodynamic therapy. To this end, we report herein a novel dual receptor‐mediated bioorthogonal activation approach to enhance the tumor specificity of the photodynamic action. It involves the targeted delivery of a biotinylated boron dipyrromethene (BODIPY)‐based photosensitizer, which is quenched in the native form by the attached 1,2,4,5‐tetrazine unit, and an epidermal growth factor receptor (EGFR)‐targeting cyclic peptide conjugated with a bicycle[6.1.0]non‐4‐yne moiety. Only for cancer cells that overexpress both the biotin receptor and EGFR, the two components can be internalized preferentially where they undergo an inverse electron‐demand Diels–Alder reaction, leading to restoration of the photodynamic activity of the BODIPY core. By using a range of cell lines with different expression levels of these two receptors, we have demonstrated that this stepwise “deliver‐and‐click” approach can confine the photodynamic action on a specific type of cancer cells.
A Highly Compatible Phototrophic Community for Carbon‐Negative Biosynthesis
Authors: Li Chaofeng , Wang Ruoyu , Wang Jiawei , Liu Liangxu , Li Hengrun , Zheng Haotian , Ni Jun
Published: November 2022

CO2 sequestration engineering is promising for carbon‐negative biosynthesis, and artificial communities can solve more complex problems than monocultures. However, obtaining an ideal photosynthetic community is still a great challenge. Herein, we describe the development of a highly compatible photosynthetic community (HCPC) by integrating a sucrose‐producing CO2 sequestration module and a super‐coupled module. The cyanobacteria CO2 sequestration module was obtained using stepwise metabolic engineering and then coupled with the efficient sucrose utilization module Vibrio natriegens. Integrated omics analysis indicated that enhanced photosynthetic electron transport and extracellular vesicles promote intercellular communication. Additionally, the HCPC was used to channel CO2 into valuable chemicals, enabling the overall release of −22.27 to −606.59 kgCO2e kg−1 in the end products. This novel light‐driven community could facilitate circular economic implementation in the future.
A Combined XPS and Computational Study of the Chemical Reduction of BMP‐TFSI by Lithium
Authors: Forster‐Tonigold K. , Buchner F. , Bansmann J. , Behm R. J. , Groß A.
Published: November 2022

Invited for this month's cover picture is the work of Prof. Groß’ and Prof. Behm's groups at the Helmholtz Institute Ulm (HIU) Electrochemical Energy Storage and Ulm University. The cover picture shows the model study on the chemical reactions of the ionic liquid BMP‐TFSI with Li atoms. The combined study of XPS experiments and DFT calculations identified various initial products in the solid‐electrolyte interphase formation. Read the full text of the Research Article at 10.1002/batt.202200307.
Nanostructured material‐based optical and electrochemical detection of amoxicillin antibiotic
Authors: Imran Mohd , Ahmed Shahzad , Abdullah Ahmad Zuhairi , Hakami Jabir , Chaudhary Anis Ahmad , Rudayni Hassan Ahmad , Khan Salah‐Ud‐Din , Khan Afzal , Basher Nosiba Suliman
Published: November 2022

The penicillin derivative amoxicillin (AMX) plays an important role in treating various types of infections caused by bacteria. However, excessive use of AMX may have negative health effects. Therefore, it is of utmost importance to detect and quantify the AMX in pharmaceutical drugs, biological fluids, and environmental samples with high sensitivity. Therefore, this review article provides valuable and up‐to‐date information on nanostructured material‐based optical and electrochemical sensors to detect AMX in various biological and chemical samples. The role of using different nanostructured materials on the performance of important optical sensors such as colorimetric sensors, fluorescence sensors, surface‐enhanced Raman scattering sensors, chemiluminescence/electroluminescence sensors, optical immunosensors, optical fibre‐based sensors, and several important electrochemical sensors based on different electrode types have been discussed. Moreover, nanocomposites, polymer, and MXenes‐based electrochemical sensors have also been discussed, in which such materials are being used to further enhance the sensitivity of these sensors. Furthermore, nanocomposite‐based photo‐electrochemical sensors and the market availability of biosensors including AMX have also been discussed briefly. Finally, the conclusion, challenges, and future perspectives of the above‐mentioned sensing techniques for AMX detection are presented.
Modeling an immune response to influenza A virus infection in alveolar epithelial cells
Authors: Miller Marissa L. , Brown Deborah M. , Wysocki Tadeusz A.
Published: November 2022

Influenza A viruses (IAV) have been the cause of several influenza pandemics in history and are a significant threat for the next global pandemic. Hospitalized influenza patients often have excess interferon production and a dysregulated immune response to the IAV infection. Obtaining a better understanding of the mechanisms of IAV infection that induce these harmful effects would help drug developers and health professionals create more effective treatments for IAV infection and improve patient outcomes. IAV stimulates viral sensors and receptors expressed by alveolar epithelial cells, like RIG‐I and toll‐like receptor 3 (TLR3). These two pathways coordinate with one another to induce expression of type III interferons to combat the infection. Presented here is a queuing theory‐based model of these pathways that was designed to analyze the timing and amount of interferons produced in response to IAV single stranded RNA and double‐stranded RNA detection. The model accurately represents biological data showing the necessary coordination of the RIG‐I and TLR3 pathways for effective interferon production. This model can serve as the framework for future studies of IAV infection and identify new targets for potential treatments.
Understand how FERPA applies to sex offender registries
Authors: Rainsberger Richard
Published: November 2022

The Family Educational Rights and Privacy Act governs how student records may be used and disclosed. For campus law enforcement and safety officers, records governed by FERPA may include records pertaining to student conduct and the intersection with other records such as a sex offender registry.
Peptoid‐Peptide Hybrid Analogs of the Enterococcus faecalis Fsr Auto‐Inducing Peptide (AIP) Reveal Crucial Structure‐Activity Relationships
Authors: McBrayer Dominic N. , Ghosh Uttam , Lella Muralikrishna , Cameron Crissey D. , Tal‐Gan Yftah
Published: November 2022

As multidrug‐resistant bacteria become a more pressing risk to human health, alternate approaches to treating bacterial infections are being increasingly investigated. Enterococcus faecalis is an opportunistic pathogen responsible for a large percentage of secondary enterococci infections. Its pathogenicity has been shown to be largely dependent on a cell‐density communication mechanism, termed quorum sensing. In this study, we conducted a systematic investigation of the lactone‐containing macrocyclic signaling peptide used by E. faecalis for Fsr‐mediated communication, termed gelatinase biosynthesis activating pheromone (GBAP). Specifically, through a combination of the on‐resin sub‐monomer and solution phase peptoid building block synthesis approaches, we successfully synthesized a library of peptoid‐peptide hybrid analogs of GBAP and determined the biological effects associated with the introduction of the peptoid (N‐alkyl glycine derivative) modifications. Within the macrocycle region of the peptide, as have been seen with other modifications, the F7 site was unusually tolerant toward peptoid modification, compared with other macrocyclic sites. Interestingly, within the exocyclic tail, peptoid modification at the N2 site completely abolished activity, a first for a single tail modification.