bluuebunny/crossref_metadata_2025 huggingface dataset:
CyberKnife radiosurgery for trigeminal neuralgia: a retrospective review of 168 cases
Authors: Guillemette Albert , Heymann Sami , Roberge David , Ménard Cynthia , Fournier-Gosselin Marie-Pierre
Published: November 2022

OBJECTIVE

Gamma Knife radiosurgery is recognized as an efficient intervention for the treatment of refractory trigeminal neuralgia (TN). The CyberKnife, a more recent frameless and nonisocentric radiosurgery alternative, has not been studied as extensively for this condition. This study aims to evaluate the clinical outcomes of a first CyberKnife radiosurgery (CKRS) treatment in patients with medically refractory TN.

METHODS

A retrospective cohort study of 166 patients (168 procedures) with refractory TN treated from 2009 to 2021 at the Centre Hospitalier de l’Université de Montréal was conducted. The treatment was performed using a CyberKnife (model G4, VSI, or M6). The treatment median maximum dose was 80 (range 70.0–88.9) Gy.

RESULTS

Adequate pain relief, evaluated using Barrow Neurological Institute pain scale scores (I–IIIb), was achieved in 146 cases (86.9%). The median latency period before adequate pain relief was 35 (range 0–202) days. The median duration of pain relief for cases with a recurrence of pain was 8.3 (range 0.6–85.0) months. The actuarial rates of maintaining adequate pain relief at 12, 36, and 60 months from the treatment date were 77.0%, 62.5%, and 50.2%, respectively. There was new onset or aggravation of facial numbness in 44 cases (26.2%). This facial numbness was predictive of better maintenance of pain relief (p < 0.001). The maintenance of adequate pain relief was sustained longer in idiopathic cases compared with cases associated with multiple sclerosis (MS; p < 0.001).

CONCLUSIONS

In the authors’ experience, CKRS for refractory TN is efficient and safe. The onset or aggravation of facial hypoesthesia after treatment was predictive of a more sustained pain relief, and idiopathic cases had more sustained pain relief in comparison with MS-related cases.
Risk factors for peritumoral edema after radiosurgery for intracranial benign meningiomas: a long-term follow-up in a single institution
Authors: Huang Sheng-Han , Chuang Chi-Cheng , Wang Chun-Chieh , Wei Kuo-Chen , Chen Hsien-Chih , Hsu Peng-Wei
Published: November 2022

OBJECTIVE

Peritumoral edema (PTE) is recognized as a complication following stereotactic radiosurgery (SRS). The aim of this paper was to evaluate the risk of post-SRS PTE for intracranial benign meningiomas and determine the predictive factors.

METHODS

Between 2006 and 2021, 227 patients with 237 WHO grade I meningiomas were treated with Novalis linear accelerator SRS. All patients were treated with a single-fraction dose of 11–20 Gy (median 14 Gy). The median tumor volume was 3.32 cm3 (range 0.24–51.7 cm3).

RESULTS

The median follow-up was 52 months (range 12–178 months). The actuarial local tumor control rates at 2, 5, and 10 years after SRS were 99.0%, 96.7%, and 86.3%, respectively. Twenty-seven (11.9%) patients developed new or worsened post-SRS PTE, with a median onset time of 5.2 months (range 1.2–50 months). Only 2 patients developed post-SRS PTE after 24 months. The authors evaluated factors related to new-onset or worsened PTE after SRS. In univariate analysis, initial tumor volume > 10 cm3 (p = 0.03), total marginal dose > 14 Gy (p < 0.001), preexisting edema (p < 0.0001), tumor location (p < 0.001), parasagittal location (p < 0.0001), superior sagittal sinus (SSS) involvement (p < 0.0001), and SSS invasion (p < 0.015) were found to be significant risk factors. In multivariate analysis, total marginal dose > 14 Gy (HR 3.38, 95% CI 1.37–8.33, p = 0.008), preexisting SRS edema (HR 12.86, 95% CI 1.09–4.15, p < 0.0001), tumor location (HR 2.13, 95% CI 1.04–3.72, p = 0.027), parasagittal location (HR 8.84, 95% CI 1.48–52.76, p = 0.017), and SSS invasion (HR 0.34, 95% CI 0.13–0.89, p = 0.027) were significant risk factors. Twelve (5.3%) patients were symptomatic. Ten of 27 patients had complete resolution of neurological symptoms and edema improvement with steroid treatment. Steroid treatment failed in 2 patients, who subsequently required resection for PTE.

CONCLUSIONS

Radiosurgery is a safe and effective method of treating benign intracranial meningiomas according to long-term follow-up. We also identified total marginal dose > 14 Gy, preexisting PTE, parasagittal location, and SSS invasion as predictors of post-SRS PTE. Risk factors for post-SRS PTE should be considered in meningioma treatment.
Stereotactic radiosurgery for trigeminal neuralgia secondary to tumor: a single-institution retrospective series
Authors: Hall Jennifer C. , Ung Timothy H. , McCleary Tamra-Lee , Chuang Cynthia , Gibbs Iris C. , Soltys Scott G. , Hayden Gephart Melanie , Li Gordon , Pollom Erqi L. , Chang Steven D. , Meola Antonio
Published: November 2022

OBJECTIVE

Trigeminal neuralgia (TN) secondary to tumor represents a rare and diverse entity, and treatment for secondary TN remains controversial. This report reviews a single institution’s experience in treating secondary TN with stereotactic radiosurgery (SRS) and focuses on the durability of pain relief with respect to various treatment targets, i.e., the trigeminal nerve, offending tumor, or both.

METHODS

Between the years 2009 and 2021, 21 patients with TN secondary to benign (n = 13) or malignant (n = 8) tumors underwent SRS. Barrow Neurological Institute (BNI) pain intensity scale scores were collected from patient electronic medical records at baseline, initial follow-up, and 1 and 3 years post-SRS. The interval change in BNI scale score (ΔBNI) at the various follow-up time points was also calculated to assess the durability of pain relief following SRS.

RESULTS

The median follow-up period was 24 (range 0.5–155) months. Five patients (24%) received treatment to the trigeminal nerve only, 10 (48%) received treatment to the tumor only, and 6 (29%) had treatment to both the nerve and tumor. The overall radiation dosage ranged from 14 to 60 Gy delivered in 1–5 fractions, with a median overall dose of 26 Gy. The median dose to the tumor was 22.5 (range 14–35) Gy, delivered in 1–5 fractions. Of the treatments targeting the tumor, 25% were delivered in a single fraction with doses ranging from 14 to 20 Gy, 60% were delivered in 3 fractions with doses ranging from 18 to 27 Gy, and 15% were delivered in 5 fractions with doses ranging from 25 to 35 Gy. The most common dose regimen for tumor treatment was 24 Gy in 3 fractions. The median biologically effective dose (with an assumed alpha/beta ratio of 10 [BED10]) for tumor treatments was 43.1 (range 13.3–60.0) Gy. There was a significant difference in the proportion of patients with recurrent pain (ΔBNI score ≥ 0) at the time of last follow-up across the differing SRS treatment targets: trigeminal nerve only, tumor only, or both (p = 0.04). At the time of last follow-up, the median ΔBNI score after SRS to the nerve only was −1, 0 after SRS to tumor only, and −2 after SRS to both targets.

CONCLUSIONS

SRS offers clinical symptomatic benefit to patients with TN secondary to tumor. For optimal pain relief and response durability, treatment targeting both the tumor and the trigeminal nerve appears to be most advantageous.
STUDI RASIONALISASI POS HIDROLOGI DI WILAYAH SUNGAI NOELMINA PROVINSI NUSA TENGGARA TIMUR
Authors: Sarwanta Sarwanta , Abdulgani Hamdani
Published: November 2022

Perencanaan infrastruktur sumber daya air memerlukan data pendukung hidrologi yang sahih. Data pendukung tersebut diantarnya data catatan curah hujan, data catatan debit banjir dan data pantauan cuaca selama kurun waktu tertentu. Data hidrologi yang sahih dapat diperoleh dari alat pemantau yang representatif baik dari sisi jumlah maupun penempatannya di suatu kawasan tertentu. Studi ini menganalisis jumlah dan distribusi penempatan pos pemantau hujan, debit banjir dan cuara yang ada saat ini (eksisting) di Wilayah Sungai (WS) Noelmina. Hasil analisis berupa rekomendasi jumlah dan distribusi (sebaran) pos pemantau curah hujan, alat pencatatat debit banjir, dan pemantau cuaca yang sesuai karakteristik wilayah sungai Noelmina. Studi rasionalisasi pos hidrologi mengidentifikasi jumlah, posisi dan kondisi pos hidrologi yang ada, kemudian membandingkan dengan jumlah dan posisi pos yang ideal sesuai standar dan merekomendasikan langkah yang harus dilakukan agar keberadaan pos hidrologi sesuai standar. Hasil studi terhadap keberadaan pos hidrologi di Wilatah Sungai Noelmina yaitu terdapat 14 (empat belas) pos pencatatat curah hujan direkomendasikan direhabilitasi, 7 (tujuh) pos pencatat curah hujan direkomendasikan direlokasi. 5 (lima) pos pencatat debit banjir direkomendasikan dilakukan rehabiltasi dan 2 (dua) pos pencatat debit banjir direkomendasikan untuk dilakukan relokasi. 1(satu) pos pemantau cuaca direkomendasikan dihabilitasi dan 2 (dua) pos pemantau cuaca direkomendasikan direlokasi.
EVALUASI INVESTASI PEMBANGUNAN PERUMAHAN MENGGUNAKAN PENDEKATAN ANALISIS SENSITIVITAS
Authors: Rochman Nur Fatur , Suhana Nono
Published: November 2022

Pesatnya pertumbuhan penduduk kabupaten atau kota di Indonesia meningkatkan permintaan pasar akan tempat tinggal sebagai prioritas utama. Maka, para pengembang mulai menaruh perhatian pada peluang investasi pembangunan perumahan, terutama pada pembangunan perumahan di kawasan perkotaan. Oleh karena itu, sebelum melakukan investasi pembangunan perumahan dilakukan, perlu dilakukan studi secara ekonomi teknik untuk menentukan kelayakan pembangunan perumahan yang akan dibangun. Dalam penelitian ini bertujuan untuk mengevaluasi sebuah investasi perumahan yang akan dibangun di daerah Kabupaten/Kota Kuningan. Pada penelitian ini, penulis merencanakan menggunakan dua alternatif dalam investasi perumahan untuk menentukan PP (Payback Period), NPV (Net Present Value), IRR (Internal Rate of Return), dan BCR (Benefit Cost Ratio) diantaranya Alternatif A dan Alternatif B. Pada pendekatan Analisis Sensitivitas dari masingmasing kedua alternatif yang dianalisis sensitivitasnya yaitu 1) Sensitivitas Investasinya 2) Sensitivitas Benefitnya dan 3) Sensitivitas biaya Operasionalnya.
PENGARUH PENGGUNAAN SUBTITUSI LIMBAH GENTENG PADA AGREGAT KASAR DAN AGREGAT HALUS PADA BETON TERHADAP KUAT TEKAN DAN KUAT TARIK BETON
Authors: Paslah Ronny , Suhana Nono
Published: November 2022

Limbah bahan bangunan seperti genteng baik yang masih utuh maupun yang sudah pecah banyak di temukan di daerah maupun perkoataan. Dalam hal ini peneliti bermaksud untuk memanfaatkan pecahan genteng tersebut mengganti sebagian agregat kasar dalam campuran beton. Diharapkan dengan pecahan genteng harga agregat berkurang atau lebih irit tetapi tanpa mengurangi mutu kuat tekan dan kuat tarik dari beton yang ada. Penelitian ini merupakan eksperimental yang diwujudkan melalui serangkaian analisis dan pengujian laboratorium terhadap beton normal yang di subtitusikan dari limbah genteng dengan campuran 5 %, 10 %, 15 %, 20 %, selama 7 hari, 14 hari, 21 hari, dan 28 hari. Hasil nilai kuat tekan beton subtitusi 5%, 10%,15%, dan 20% beton umur 28 hari masing -masing sebesar 17,91Mpa, 13,58 MPa, 10,75 MPa, dan 8,96 MPa. Penurunan kuat tekan beton subtitusi 5%, 10%, 15%, dan 20% beton umur 28 hari masing – masing sebesar 28,58%, 45,85%, 57, 13% dan 64,27%. Sedangkan kuat tarik belah beton subtitusi 5%, 10%, 15%, dan 20% beton umur 28 hari masing- masing sebesar 9,05 MPa,7,73 MPa, 6,79 MPa dan 5,66 MPa. Penurunan kuat tarik belah subtitusi 5%, 10%, 15%, dan 20% beton umur 28 hari masing – masing sebesar 39,26%, 48,12%, 54,42% dan 62,01%
MODEL BANGKITAN DAN TARIKAN PADA PUSAT KEGIATAN PERGURUAN TINGGI DI KABUPATAEN INDRAMAYU
Authors: Sarwanta Sarwanta , Abdulgani Hamdani , Arief Oki
Published: November 2022

Setiap pusat kegiatan akan menimbulkan dampak lalu lintas pada jalan akses yang menghubungkan pusat kegiatan tersebut dengan lingkungan sekitarnya.  Lalu lintas yang ditimbulkan berupa lalu lintas menuju pusat kegiatan (tarikan) maupun lalu lintas yang meninggalkannya (Bangkitan). Keberadaan kampus di kota Indramayu sebagai salah satu pusat kegiatan pendidikan perlu diketahui dampak lalu lintas yang ditimbulkannya. Tujuan dari penelitian ini untuk menyusun model bangkitan dan tarikan lalu lintas untuk mengetahui besarnya dampak lalu lintas yang timbul dengan adanya keberadaan perguruan tinggi yang ada di Kota Indramayu. Dengan diketahuinya dampak lalu lintas yang ditimbulkan, maka dapat membantu pihak yang berwenang membuat kebijakan untuk langkah antisipasi. Hasil analisis faktor yang mempengaruhi tarikan dan bangkitan perjalanan kendaraan di beberapa perguruan tinggi yang ada di Kabupaten Indramayu yaitu jumlah mahasiswa. Model tarikan perjalanan kendaraan menuju perguruan tinggi yang ada di Kabupaten Indramayu adalah Y1 = 22,432 + 0,040X1, dengan Y1 =Tarikan perjalanan kendaraan (smp/jam) dan X1 adalah Jumlah mahasiswa (orang). Model bangkitan lalu lintasnya adalah Y2 = 10,500 + 0,040 X1, Dimana Y2 adalah bangkitan perjalanan kendaraan (smp/jam) dan X1 adalah Jumlah mahasiswa (orang).
Kesalahan siswa dalam menyelesaikan soal cerita tentang bangun ruang sisi lengkung menggunakan prosedur newman
Authors: Lestari Liya , Afriansyah Ekasatya Aldila
Published: November 2022

The fact that many students still struggle with mathematical concepts like the material of curved side space is what spurred this research. This study set out to investigate the errors that students make when applying Newman's technique to narrative problems with curved side spaces. Methodology for descriptive qualitative research is used. Three students who reside in the village of Radug were selected as samples using the purposive sampling technique from a population of all students who had studied the Constructing Curved Side Space content. Tests, field notes, observations, and interviews are just a few of the data collection procedures used. The steps of data reduction, presentation, and conclusion are the data analysis technique used. According to the study's findings, there were 16% reading errors, 50% problem understanding errors, 33% transformation errors, 55% process skills faults, and 59% writing errors in the final answer. Problem-solving is still a joint task that must be solved, so there is a need for other research that can help analyze mathematical errors. Penelitian ini dilatarbelakangi oleh masih banyaknya siswa yang mengalami kesulitan dalam memahami ide-ide dasar matematika, termasuk ruang sisi lengkung. Penelitian ini melihat kesalahan yang dibuat siswa saat memanfaatkan proses Newman untuk menyelesaikan cerita ruang sisi lengkung. Metodologi penelitian ini adalah deskriptif kualitatif. Purposive sampling digunakan untuk mengambil tiga siswa dari desa Radug sebagai sampel dari populasi semua siswa yang sebelumnya telah mempelajari konten untuk Membangun Sisi Lengkung Ruang. Beberapa metode yang digunakan untuk mengumpulkan data meliputi tes, catatan, observasi, dan wawancara. Teknik analisis data meliputi tahapan reduksi data, penyajian, dan penarikan data. Menurut temuan penelitian, ada 16% kesalahan membaca, 50% kesalahan pemahaman masalah, 33% kesalahan transformasi, 55% kesalahan keterampilan proses, dan 59% kesalahan menulis dalam jawaban akhir. Pemecahan masalah masih menjadi tugas bersama yang harus diselesaikan, maka perlu adanya penelitian lain yang bisa membantu menganalisa kesalahan matematis.
Improvement of Crop Production Planning in Ukraine Using the Cobb-Douglas Production Function
Authors: Dolgikh Yana
Published: November 2022

The relevance of the study is conditioned by the need to improve the process of planning the crop production by agricultural enterprises of Ukraine through the construction of a functional relationship between the results of production activities of enterprises and the factors that determine these results. The purpose of the study is to improve the process of planning crop production by agricultural enterprises of Ukraine through the development of an econometric model in the form of a Cobb-Douglas production function. To model the processes of crop production, it is proposed to use the Cobb-Douglas production function, which describes the dependence of the crop production index on the indices of agricultural land acreage and labour productivity. Based on statistical information for 1996-2020, unknown parameters of the Cobb-Douglas production function were found by regression analysis. The high quality of the constructed model is substantiated. High predictive properties of the model are proved. To analyse the efficiency of resource use in crop production by agricultural enterprises, the coefficients of average, marginal products of labour and capital are calculated. The sensitivity of crop production to changes in crop areas and labour productivity is investigated. It is determined that if the index of agricultural areas is increased by 1%, the index of crop production will increase by 0.77%; and if the index of labour productivity is increased by 1%, the index of crop production will increase by 0.81%. An increasing return on the scale of resources spent is revealed, which indicates an increase in production volumes with an increase in the volume of resources in the crop production industry.
Prospects for the Development of the Seed Industry in Ukraine
Authors: Grunwald Nataliia , Zakharchuk Oleksandr , Matsybora Tetiana
Published: November 2022

Given the significant production and export potential of the crop sector in Ukraine, it is important to develop an effective national seed production system. Providing agricultural producers with seeds of national selection is one of the main factors of food security in the country. The development of an effective seed production system provides for the creation of appropriate conditions for increasing seed production and popularising national varieties and hybrids that have a significant yield potential and high-quality indicators for their wider use, which will ensure the competitive advantages of agricultural production and its development. The purpose of the study is to identify trends and outline development prospects for the seed industry of Ukraine. In the course of the study, the dialectical method, analysis and synthesis, system generalisation (establishing trends in the development of the Ukrainian seed industry; forming conclusions), and comparative analysis (determining the main problems of seed production development in Ukraine) were applied. Trends in the development of the seed industry in Ukraine are established. The main problems of seed production development are identified and measures to stimulate selection activities in Ukraine are proposed. Prospects for the development of Ukrainian seed production are outlined. Conclusions, suggestions, and practical recommendations can be used in the development of national programmes to support seed production in Ukraine.
Interstitial washdown during crystalloid fluid loading in graded hypovolemia –A retrospective analysis in volunteers
Authors: Hahn Robert G.
Published: November 2022

BACKGROUND: “Interstitial washdown” is an edema-preventing mechanism that implies a greater redistribution of interstitial albumin occurs whenever the capillary filtration is increased. OBJECTIVE: To study the effect of interstitial washdown on fluid distribution in normovolemic and hypovolemic volunteers. METHODS: Capillary filtration was increased by infusing 25 mL/kg Ringer’s acetate intravenously over 30 min 10 male just after withdrawal of 0, 450, and 900 mL of blood. Population volume kinetic analysis was used to assess the effects of washdown and hemorrhage on fluid distribution, using the difference in plasma dilution based on hemoglobin and albumin as biomarker of washdown. RESULTS: Blood withdrawal during 10–15 min recruited 100–150 mL of fluid of high albumin content to the plasma, which was probably lymph. The albumin recruitment was temporarily reduced during the fluid loading but increased from 40 min post-infusion and was then greater when preceded by hemorrhage. Simulations suggested that interstitial washdown decreased the extravascular fluid volume by 200 mL over 3 h. The plasma volume and urinary excretion both increased by approximately half this amount. CONCLUSIONS: Blood loss without hypotension probably recruited lymph to the plasma, but interstitial washdown played no major role in determining the distribution of crystalloid fluid after hemorrhage.
CircIRAK1 aggravates ox-LDL-induced endothelial cell injury in atherosclerosis via TRIM14 upregulation by binding to miR-330-5p
Authors: Liu Fang , Gao Bo , Wang Yu
Published: November 2022

BACKGROUND: Atherosclerosis (AS) is a common inflammatory cardiovascular disease, and circular RNAs (circRNAs) are associated with the pathogenesis of AS. CircRNA Interleukin (IL)-1 receptor-associated kinase 1 (circIRAK1, hsa_circ_0091822) was upregulated in AS. The aims of this study were to ascertain the function and mechanism of circIRAK1 in AS. METHODS: Human Umbilical Vein Endothelial Cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL). RNA expression was detected by reverse transcription-quantitative polymerase chain reaction assay. Cell viability was examined using Cell Counting Kit-8 assay. Tube formation ability was measured by tube formation assay. Cell apoptosis was assessed using flow cytometry. Western blot was used for protein detection. Inflammatory reaction was evaluated via Enzyme-linked immunosorbent assay. Oxidative injury was analyzed by commercial kits. Target binding was determined through dual-luciferase reporter assay, RNA immunoprecipitation assay and pull-down assay. RESULTS: The expression of circIRAK1 was upregulated in AS serums and ox-LDL-treated HUVECs. Silencing circIRAK1 enhanced cell viability and angiogenesis while suppressed cell apoptosis, inflammatory response and oxidative stress in ox-LDL-stimulated HUVECs. CircIRAK1 served as a molecular sponge for miR-330-5p. CircIRAK1 regulated ox-LDL-mediated cell injury by absorbing miR-330-5p. In addition, miR-330-5p prevented endothelial cell dysfunction caused by ox-LDL via targeting tripartite motif containing 14 (TRIM14). TRIM14 expression was upregulated by circIRAK1 through sponging miR-330-5p. CONCLUSION: These results suggested that circIRAK1 upregulated TRIM14 by interacting with miR-330-5p, consequently contributing to ox-LDL-induced endothelial cell injury in AS.
Mathematical-heuristic modelling for human performance envelope
Authors: Rusu Victoria , Calefariu Gavrila
Published: November 2022

BACKGROUND: Using the theory of complex systems, some human functions (thinking, memory, language) and human relationships have been analyzed and explained. In order to study the limits of human performance (in Air Traffic Controllers and pilots) a new concept was created, called the Human Performance Envelope (HPE). OBJECTIVE: The aim of this paper is to apply the principles of the complex system to the analysis of the human factors of the HPE concept. Moreover, this paper’s objective is to create a mathematical model that will give the opportunity to study all the physiological ergonomic factors, not only the ones that are most commonly studied. The most studied factors are mental workload, stress and situation awareness (SA). By applying the mathematical model, it is possible to analyze all the physiological factors (stress, mental workload, fatigue, attention, vigilance and SA). METHODS: In the present paper the theory of complex systems (hybrid modelling) was applied to the Human Performance Envelope concept. A mathematical model was created, then it was validated and solved based on previous researches. RESULTS: Firstly, a literature analysis was performed on the complex systems application by the present researchers concerning pilots’ HPE. The proportional and inverse proportional relationships between the nine human factors were visually illustrated. Finally, a mathematical model was proposed, consisting of a set of equations, which were partially solved and validated by the experiments on pilots done by other researchers. CONCLUSIONS: Further research is required to validate the whole mathematical model, including physiological measurements (experiments) for the six ergonomic factors and the applied heuristic psychosocial methods for the others.
Local passive heating administered during recovery impairs subsequent isokinetic knee extension exercise performance
Authors: Chang Yongling , Liu Xin , Hurr Chansol
Published: November 2022

BACKGROUND:

Passive heating has attracted attention as a potentially promising recovery modality in sports. However, investigations of passive heating have yielded only inconsistent results for exercise performance.

OBJECTIVE:

To investigate the acute effects of local passive heating administered between repeated bouts of isokinetic exercise.

METHODS:

The experiment was a randomized crossover study. There was a total of three visits including a familiarization visit. During the remaining two visits, eleven healthy men performed three bouts of nine sets of isokinetic knee extensions using their dominant single-leg (30 repetitions/set, 180[Formula: see text]/sec). A 15 min recovery, during which a local passive heating pad at control (CON) or heating (HT) was applied to the rectus femoris, was afforded after the 3rd and 6th sets (Recovery 1 and 2). Isokinetic exercise performance, as assessed by peak torque, total work, and average power was analyzed using two-way repeated-measures ANOVA.

RESULTS:

Following Recovery 1 and 2, isokinetic exercise performance, as assessed by peak torque, total work, and average power was reduced in Set 4 ([Formula: see text] 0.001, [Formula: see text] 0.001, [Formula: see text] 0.080) and Set 7 ([Formula: see text] 0.001, [Formula: see text] 0.001, [Formula: see text] 0.009) in the HT group relative to the CON group. Electromyography analysis revealed that signal amplitude was lower in the HT group in Set 4 ([Formula: see text] 0.001) subsequent to Recovery 1, and that firing frequency was higher in Set 7 ([Formula: see text] 0.002) in the HT group after Recovery 2. Furthermore, EMG time-frequency maps from one representative participant showed that following Recovery 1 and 2 peak energy decreased during the first five repetitions in Set 4 and 7.

CONCLUSIONS:

Local passive heating administered during recovery decreased subsequent performance of isokinetic knee extensors, muscle activation ability and increased firing frequency maintaining force output. Therefore, local passive heating is not an appropriate acute recovery strategy for isokinetic exercises.
Effects of the intensity of interval training on aerobic fitness, body composition and resting metabolic rate of women with overweight or obesity: A randomized trial
Authors: Andreato Leonardo Vidal , Andrade Alexandro , Keech Andrew , da Silva Valmir , Francisco Walker William , Milani Felipe Tiburcio , de Souza Genta Laura , Branco Braulio Henrique Magnani
Published: November 2022

BACKGROUND:

Moderate-intensity interval training (MIIT) may be a viable exercise format for improving body composition, aerobic fitness, and health-related variables.

OBJECTIVES:

This randomized trial aimed to analyze the effect of MIIT or high-intensity interval training (HIIT) on aerobic fitness, body composition variables, and resting metabolic rate (RMR) in women with overweight or obesity.

METHODS:

31 sedentary adult women with overweight or obesity performed 7 weeks [Formula: see text] 3 weekly sessions of either HIIT or MIIT. Physical and physiological tests were applied before and after training.

RESULTS:

In both analyses (intention-to-treat and by adherence to the training), aerobic fitness showed a time effect ([Formula: see text] 0.041 and [Formula: see text] 0.015), but without differences between groups ([Formula: see text] 0.05). No group (HIIT vs. MIIT), time (pre vs. post), or interaction effects (group vs. time) were found for RMR, body composition markers (fat mass, body fat percentage, lean mass), or body mass index – BMI ([Formula: see text] 0.05). In addition, MIIT induced a relatively high drop-out rate.

CONCLUSIONS:

This study suggested that the short-term (7-weeks) interval exercise training was effective for increasing aerobic fitness, and moderate-intensity intervals were as effective as high-intensity intervals. However, neither training format was effective for changing RMR, body composition variables, or BMI of women with overweight or obesity. Clinical trial ID: RBR-9jd7b7.
Antidepressant Effects of a Multimodal Group Therapy Program for Mild Dementia: A Retrospective Evaluation of Clinical Routine Data
Authors: Bartels Claudia , Abdel-Hamid Mona , Wiltfang Jens , Schneider Anja , Belz Michael
Published: November 2022

Background: The multimodal CORDIAL treatment concept for mild dementia, combining cognitive rehabilitation, cognitive behavioral and humanistic psychology interventions, has proven its feasibility and demonstrated a reduction of depressive symptoms in individual dyadic/triadic settings. Objective: We investigate antidepressant effects of an adapted group-based CORDIAL program in clinical routine care. Methods: During 2013 and 2017, 51 outpatients with mild dementia (45% female, mean age 72.4 years, 67% Alzheimer’s dementia, mean MMST 24.8) periodically received a modified CORDIAL group treatment as part of our regular outpatient care. Treatment comprised 10 bi-weekly sessions, partly involving caregivers. Systematic pre- and post-treatment assessments of clinical routine data were evaluated retrospectively (median time-interval of 6.6 months). Results: Depressive symptoms as measured by the Geriatric Depression Scale significantly decreased over time (p = 0.007, Cohen’s d = 0.39), and irrespective of gender. Patients with longer disease duration before treatment start showed significantly higher initial levels of depressive symptoms (p = 0.044), followed by a reduction to a level of those with shorter disease duration (ns). Most secondary outcomes (cognitive symptoms, disease severity, quality of life, caregiver burden) remained unchanged (ns), while competence in activities of daily living declined from pre- to post-measurement (p = 0.033). Conclusion: A group-based CORDIAL treatment is feasible in a clinical routine setting and demonstrated antidepressant effects comparable to those of the individual treatment design, further suggesting its implementation in regular care. Future trials might also investigate its potentially preventive effects by reducing depressive symptoms in pre-dementia stages, even at a subsyndromal level.
Improved Alzheimer’s Disease versus Frontotemporal Lobar Degeneration Differential Diagnosis Combining EEG and Neurochemical Biomarkers: A Pilot Study
Authors: Laton Jorne , Van Schependom Jeroen , Goossens Joery , Wiels Wietse , Sieben Anne , De Deyn Peter Paul , Goeman Johan , Streffer Johannes , van der Zee Julie , Martin Jean-Jacques , Van Broeckhoven Christine , De Vos Maarten , Bjerke Maria , Nagels Guy , Engelborghs Sebastiaan
Published: November 2022

Background: Distinguishing between Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) results in poor diagnostic accuracy. Objective: To investigate the utility of electroencephalography (EEG)-based biomarkers in comparison and in addition to established cerebrospinal fluid (CSF) biomarkers in the AD versus FTLD differential diagnosis. Methods: The study cohort comprised 37 AD and 30 FTLD patients, of which 17 AD and 9 FTLD patients had definite diagnoses. All participants had CSF neurochemical (NCM) biomarker analyses (Aβ1-42, T-tau, P-tau181, and Nf-L) and underwent 19-channel resting-state EEG. From the EEG spectra, dominant frequency peaks were extracted in four regions resulting in four dominant frequencies. This produced eight features (4 NCM + 4 EEG). Results: When NCM and EEG markers were combined, the diagnostic accuracy increased significantly. In the whole group, the accuracy went up from 79% (NCM) to almost 82%, while in the definite group only, it went up from around 85% to almost 95%. Two differences in the occurrence of the dominant EEG frequency were discovered: people lacking a clear dominant peak almost all had definite AD, while people with two peaks more often had FTLD. Conclusion: Combining EEG with NCM biomarkers resulted in differential diagnostic accuracies of 82% in clinically diagnosed AD and FTD patients and of 95% in patients having a definite diagnosis, which was significantly better than with EEG or NCM biomarkers alone. This suggests that NCM and EEG markers are complementary, revealing different aspects of the disease and therefore confirms again their relevance in developing additional diagnosis tools.
Pathological (Dis)Similarities in Neuronal Exosome-Derived Synaptic and Organellar Marker Levels Between Alzheimer’s Disease and Frontotemporal Dementia
Authors: Krishna Geethu , Santhoshkumar Rashmi , Sivakumar Palanimuthu Thangaraju , Alladi Suvarna , Mahadevan Anita , Dahale Ajit B. , Arshad Faheem , Subramanian Sarada
Published: November 2022

Background:

Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are pathologically distinct neurodegenerative disorders with certain overlap in cognitive and behavioral symptoms. Both AD and FTD are characterized by synaptic loss and accumulation of misfolded proteins, albeit, in different regions of the brain.

Objective:

To investigate the synaptic and organellar markers in AD and FTD through assessment of the levels of synaptic protein, neurogranin (Ng) and organellar proteins, mitofusin-2 (MFN-2), lysosomal associated membrane protein-2 (LAMP-2), and golgin A4 from neuronal exosomes.

Methods:

Exosomes isolated from the plasma of healthy controls (HC), AD and FTD subjects were characterized using transmission electron microscopy. Neurodegenerative status was assessed by measurement of neurofilament light chain (NfL) using Simoa. The pooled exosomal extracts from each group were analyzed for Ng, MFN-2, LAMP-2, and golgin A4 by western blot analysis using enhanced chemiluminescence method of detection.

Results:

The densitometric analysis of immunoreactive bands demonstrated a 65% reduction of Ng in AD and 53% in FTD. Mitochondrial protein MFN-2 showed a significant reduction by 32% in AD and 46% in FTD. Lysosomal LAMP-2 and Golgi complex associated golgin A4 were considerably increased in both AD and FTD.

Conclusion:

Changes in Ng may reflect the ongoing synaptic degeneration that are linked to cognitive disturbances in AD and FTD. Importantly, the rate of synaptic degeneration was more pronounced in AD. Changes to a similar extent in both the dementia groups in organellar proteins indicates shared mechanisms of protein accumulation/degradation common to both AD and FTD.
A novel approach to improve network validity using various soft computing techniques
Authors: Lakshmana Kumar R. , Subramanian R. , Karthik S.
Published: November 2022

Mobile Adhoc Networks (MANET) in modern research have many optimal energy conservation mechanisms that can be deployed easily and in a faster manner. The routing approaches associated with energy consumption play a dominant role in routing the data packets between the mobile sensor nodes within the range of optimization. However, major challenges associated with energy consumption in MANETs include reduced lifetime of sensor nodes, poor coverage, and throughput. Most methods tend to reduce the interference of data while traversing between the sensor nodes and increase the capacity of the network. This results in delays while transmitting the packets across the network, and this may result in failure of packets being transmitted. To resolve this issue, in this paper, we propose an ant colony optimization combined with a flower pollination algorithm for minimal energy consumption and throughput maximisation in MANETs. This hybrid meta-heuristic model resolves the issues, including delays, poor coverage, and reduced network lifetime. This hybrid model uses the estimation of neighbourhood distance among the nodes for optimal placement of nodes for effective location. The estimation of location is found using a flower pollination algorithm with a levy flight mechanism. The estimation is carried out in a hyper sphere model that helps in finding the coverage area of the sensor nodes. Depending upon the estimation of neighbourhood distance among the sensor nodes, the consumption of energy among the sensor nodes in MANETs is reduced. The simulation was conducted between the proposed hybrid approach and conventional soft computing heuristics, where the results show that the proposed model achieves a higher rate of energy conservation and reduces delay than other methods.
A novel risk assessment model for work-related musculoskeletal disorders in tea harvesting workers
Authors: Tatar Veysel , Yazicioglu Osman , Ayvaz Berk
Published: November 2022

Work-related musculoskeletal disorders (WMSDs) are the most common occupational health problems in agriculture workers due to repetitive and excessive force movement activities involved in their job processes. The Fine-Kinney method has been commonly used as a quantitative evaluation method in risk assessment studies. Classically, the risk value via Fine–Kinney is calculated by the mathematical multiplication irrespective of the degree of importance of each risk parameter (probability (P), exposure (E), and consequence (C)). Hence, a novel risk management model was proposed based on integrating Fine-Kinney and spherical fuzzy AHP-TOPSIS. First, each risk parameter is weighted using the spherical fuzzy AHP (SF-AHP). Second, the spherical fuzzy TOPSIS (SF-TOPSIS) method is used for hazard ranking. The proposed model is applied to evaluate risks in tea harvesting workers for work-related musculoskeletal disorders. Subsequently, a sensitivity analysis is carried out to test the proposed model. Finally, we compare the proposed model’s applicability and effectiveness with the spherical fuzzy COmbinative Distance-based ASsessment (SF-CODAS) method based on Fine-Kinney. The ranking similarity between the proposed Fine-Kinney-based SF-TOPSIS and SF-CODAS methods is checked by applying Spearman’s rank correlation coefficient, in which 92% of rankings are matched.
A novel decomposition-denoising ANFIS model based on singular spectrum analysis and differential evolution algorithm for seasonal AQI forecasting
Authors: He Mingjun , Che Jinxing , Jiang Zheyong , Zhao Weihua , Wan Bingrong
Published: November 2022

Understanding and forecasting air quality index (AQI) plays a vital role in guiding the reduction of air pollution and helping social sustainable development. By combining fuzzy logic with decomposition techniques, ANFIS has become an important means to analyze the data resources, uncertainty and fuzziness. However, few studies have paid attention to the noise of decomposed subseries. Therefore, this paper presents a novel decomposition-denoising ANFIS model named SSADD-DE-ANFIS (Singular Spectrum Analysis Decomposition and Denoising-Differential Evolution-Adaptive Neuro-Fuzzy Inference System). This method uses twice SSA to decompose and denoise the AQI series, respectively, then fed the subseries obtained after the decomposition and denoising into the constructed ANFIS for training and predicting, and the parameters of ANFIS are optimized using DE. To investigate the prediction performance of the proposed model, twelve models are included in the comparisons. The experimental results of four seasons show that: the RMSE of the proposed SSADD-DE-ANFIS model is 1.400628, 0.63844, 0.901987 and 0.634114, respectively, which is 19.38%, 21.27%, 20.43%, 21.27% and 87.36%, 88.12%, 88.97%, 88.71% lower than that of the single SSA decomposition and SSA denoising. Diebold-Mariano test is performed on all the prediction results, and the test results show that the proposed model has the best prediction performance.
Prevalence and Clinical Characteristics of Dementia and Cognitive Impairment in Multiple System Atrophy: A Systematic Review and Meta-Analysis
Authors: Cui Yusha , Cao Shuangshuang , Li Fangfei , Feng Tao
Published: November 2022

Background: Cognitive impairment is a clinical feature of multiple system atrophy (MSA). However, the prevalence and factors influencing the prevalence of cognitive impairment and dementia in MSA patients remain unclear. Objective: We aim to provide an estimate of the prevalence of cognitive impairment and dementia in patients with MSA and to evaluate the possible effect of demographic, clinical and methodological factors on the prevalence. Methods: We systematically searched the PubMed, Embase, and Web of science databases to identify studies that report the prevalence of cognitive impairment or dementia in MSA published up to February 2022. We computed the estimates of the pooled prevalence using random-effects models. Heterogeneity was investigated by subgroup analyses and meta-regression. Differences between MSA patients with and without cognitive impairment in demographic and clinical features were explored. Results: A total of 23 studies comprising 2064 MSA patients were included in meta-analysis. The pooled prevalence of cognitive impairment in MSA patients was 37% (95% CI: 29% –45%), the prevalence of dementia was 11% (95% CI: 7% –15%). The subgroup analyses showed the prevalence of dementia in pathologically-confirmed MSA was 7% (95% CI: 0% –12%), in clinically diagnosed MSA was 14% (95% CI: 10% –18%). Cognitive impairment in MSA patients was associated with older age, lower education, longer disease duration and more severe motor symptoms. Conclusion: Cognitive impairment is a common non-motor symptom in MSA. Dementia can develop in a few patients with MSA as well, but usually in the late stage.
Timeliness reduction on industrial turnover index based on machine learning algorithms
Authors: Barreñada Lasai , Gálvez Sainz de Cueto Juan Carlos , Fernández Calatrava Jorge
Published: November 2022

The modernisation of the production of official statistics should make use not only of new data sources but also of novel statistical methods applied to traditional survey and administrative data. This improves the traditional quality standards. Here we present an application of statistical learning algorithms to improve the timeliness under a controlled compromise of accuracy of the Spanish Industrial Turnover Index (ITI). The methodology has been developed based on a modular and standardized approach that could be easily extended to other surveys. Our advanced index allows us to predict the ITI 31 days before publication with a median error of 0.5 points over the period Mar 2016–Apr 21, in an index with large oscillations. The results are promising and support the idea of the use of these techniques in improving the quality dimension of timeliness while accuracy is kept under control.
Better understanding the life of the user to improve the design of orthopaedic footwear
Authors: van Dijk Lianne S. , Holtkamp Fred C. , Verkerk Maarten , Wouters Eveline J.M.
Published: November 2022

BACKGROUND:

A relatively high number of users is dissatisfied with their orthopaedic device. The term ‘user practice’ was introduced to emphasise the idea that users of orthopaedic devices perform activities within an environment, which are characteristic for that environment.

OBJECTIVE:

To investigate to what extend orthopaedic shoe engineers map the specific environments in which users live and the activities they perform within these environments during the first intake for custom made orthopaedic footwear.

METHODS:

Orthopaedic shoe engineers were recruited from orthopaedic service providers across The Netherlands. The intake with a new client for orthopaedic footwear was recorded and analysed using four user environments: daily life at home, transport, work, and leisure.

RESULTS:

Our study showed that orthopaedic shoe engineers cover at best less than 50% of activities within the four user environments. Consequently, there is no guarantee that the resulting design of the orthopaedic footwear fits all of the activities and environments of the users.

CONCLUSIONS:

The principles of user practices, consisting of specific environments and activities of the user, are not yet adequately used in the field of orthopaedic shoe engineering. By not using them, too little understanding of the life of the user can result in dissatisfaction and non-usage of the orthopaedic device.
Fracture load assessment of digitally fabricated post and prefabricated fibre post in endodontically treated teeth
Authors: Sharma Swati , Makkar Monika , Luthra Reena , Arora Suraj , Pathania Poonam , Das Gotam , Chaturvedi Saurabh
Published: November 2022

BACKGROUND: Endodontically treated teeth are structurally more susceptible to root fractures. Proper tooth restorations with digitally fabricated or fibre post following endodontic therapy is essential to restore function and esthetics. OBJECTIVE: The aim of this in vitro study is to evaluate the fracture load of digitally fabricated and prefabricated fibre posts in endodontically treated teeth. METHODS: Sixty extracted human single rooted teeth were selected. The crowns were sectioned at the cement-enamel junction to standardize the remaining root length at 15 mm from the apices. Cleaning, shaping and obturation was done using conventional step back technique to an ISO K-file size 40. The roots were divided into two groups of 30 samples each: Group S: teeth reinforced with digitally fabricated posts; Group F: teeth reinforced with fibre posts. Each group was further divided into three subgroups (S7, S9, S12, F7, F9, F12) based on lengths 7, 9 and 12 mm at which the posts were cemented. Composite resin core was fabricated and prepared to receive a complete metal crown. Universal testing machine was used to measure the compressive load required to fracture the teeth. RESULTS: The highest fracture resistance of 1532N was observed with fibre posts at 12 mm of post space length followed by digitally fabricated post 1398N at 12 mm, but the difference was not statistically significant. CONCLUSION: The highest fracture resistance was observed in the teeth restored with fibre posts with 12 mm length and the lowest with digitally fabricated post with 7 mm length. As the length of post increases irrespective of type of post fracture resistance increased.