bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptome Analysis of Co-Cultures of THP-1 Human Macrophages with Inactivated Germinated Trichophyton rubrum Conidia
Authors: Cantelli Bruna Aline , Segura Gabriela Gonzalez , Bitencourt Tamires Aparecida , de Abreu Mariana Heinzen , Petrucelli Monise Fazolin , Peronni Kamila , Sanches Pablo Rodrigo , Beleboni Rene Oliveira , da Silva Junior Wilson Araújo , Martinez-Rossi Nilce Maria , Marins Mozart , Fachin Ana Lúcia
Published: May 2023

Although most mycoses are superficial, the dermatophyte Trichophyton rubrum can cause systemic infections in patients with a weakened immune system, resulting in serious and deep lesions. The aim of this study was to analyze the transcriptome of a human monocyte/macrophage cell line (THP-1) co-cultured with inactivated germinated T. rubrum conidia (IGC) in order to characterize deep infection. Analysis of macrophage viability by lactate dehydrogenase quantification showed the activation of the immune system after 24 h of contact with live germinated T. rubrum conidia (LGC). After standardization of the co-culture conditions, the release of the interleukins TNF-α, IL-8, and IL-12 was quantified. The greater release of IL-12 was observed during co-culturing of THP-1 with IGC, while there was no change in the other cytokines. Next-generation sequencing of the response to T. rubrum IGC identified the modulation of 83 genes; of these, 65 were induced and 18 were repressed. The categorization of the modulated genes showed their involvement in signal transduction, cell communication, and immune response pathways. In total, 16 genes were selected for validation and Pearson’s correlation coefficient was 0.98, indicating a high correlation between RNA-seq and qPCR. Modulation of the expression of all genes was similar for LGC and IGC co-culture; however, the fold-change values were higher for LGC. Due to the high expression of the IL-32 gene in RNA-seq, we quantified this interleukin and observed an increased release in co-culture with T. rubrum. In conclusion, the macrophages-T. rubrum co-culture model revealed the ability of these cells to modulate the immune response, as demonstrated by the release of proinflammatory cytokines and the RNA-seq gene expression profile. The results obtained permit to identify possible molecular targets that are modulated in macrophages and that could be explored in antifungal therapies involving the activation of the immune system.
Impact of Repeated Infantile Exposure to Surgery and Anesthesia on Gut Microbiota and Anxiety Behaviors at Age 6–9
Authors: Yang Xiaoyu , Wu Yan , Xu Xuanxian , Gao Wenzong , Xie Juntao , Li Zuoqing , Zhou Xue , Feng Xia
Published: May 2023

(1) Background: Preclinical as well as population studies have connected general anesthesia and surgery with a higher risk of abnormal cognitive development, including emotional development. Gut microbiota dysbiosis in neonatal rodents during the perioperative period has been reported, however, the relevance of this to human children who undergo multiple anesthesia for surgeries is unknown. Given the emerging role of altered gut microbes in propagating anxiety and depression, we sought to study whether repeated infantile exposures to surgery and anesthesia affect gut microbiota and anxiety behaviors later in life. (2) Methods: This is a retrospectively matched cohort study comparing 22 pediatric patients of less than 3 years of age with multiple exposures (≥3) to anesthesia for surgeries and 22 healthy controls with no history of exposure to anesthesia. The parent report version of the Spence Children’s Anxiety Scale (SCAS-P) was applied to evaluate anxiety in children aged between 6 and 9 years old. Additionally, the gut microbiota profiles of the two groups were compared using 16S rRNA gene sequencing. (3) Results: In behavioral tests, the p-SCAS score of obsessive compulsive disorder and social phobia were significantly higher in children with repeated anesthesia exposure relative to the controls. There were no significant differences between the two groups with respect to panic attacks and agoraphobia, separation anxiety disorder, physical injury fears, generalized anxiety disorder, and the total SCAS-P scores. In the control group, 3 children out of 22 were found to have moderately elevated scores, but none of them had abnormally elevated scores. In the multiple-exposure group, 5 children out of 22 obtained moderately elevated scores, while 2 scored as abnormally elevated. However, no statistically significant differences were detected in the number of children with elevated and abnormally elevated scores. The data show that repeated anesthesia and surgical exposures in children led to long-lasting severe gut microbiota dysbiosis. (4) Conclusions: In this preliminary study, our findings demonstrated that early repeated exposures to anesthesia and surgical predisposes children to anxiety as well as long-term gut microbiota dysbiosis. We should confirm these findings in a larger data population size and with detailed analysis. However, the authors cannot confirm an association between the dysbiosis and anxiety.
Asymmetric Effects of Financial Development on CO2 Emissions in Bangladesh
Authors: Das Anupam , Brown Leanora , McFarlane Adian
Published: May 2023

Depending on how it functions and is organized, the financial system can have a negative, positive, or zero impact on the environment. For Bangladesh, the empirical relationship between financial development and the environment, measured in terms of carbon dioxide (CO2) emissions per capita, is analysed over the period 1980 to 2020. This is the first such analysis for this country. We perform this within a non-linear bound testing framework while controlling for changes in energy consumption, gross domestic product, and trade volume. There are two key findings. One, we find that the relationship between CO2 emissions per capita and financial development is cointegrating, with the direction of cointegration running from financial development to CO2 emissions. Two, we find that positive and negative changes in financial development have asymmetric impacts on CO2 emissions in the long and short run. The implications of these findings are discussed regarding their attendant environmental policy implications.
Mechanism and Spatial Spillover Effect of New-Type Urbanization on Urban CO2 Emissions: Evidence from 250 Cities in China
Authors: Hu Chiqun , Ma Xiaoyu , Liu Yangqing , Ge Jiexiao , Zhang Xiaohui , Li Qiangyi
Published: May 2023

Exploring the effect of new-type urbanization (NTU) on urban carbon abatement is of great practical significance for promoting urban green construction and coping with the challenge of global climate change. This study used data from 250 cities in China from 2008 to 2020 and constructed the NTU evaluation indicator system from five dimensions. We used classical panel regression models to examine the effects of NTU on urban CO2 emissions, and further used spatial econometric models of SEM, SAR, and SDM to identify the spatial spillover effects of NTU on urban CO2 emissions. The main results are that China’s NTU and CO2 emissions are generally rising, and NTU has a significantly negative effect on urban CO2 emissions, with an impact coefficient of −0.9339; the conclusions still hold after subsequent robustness tests. Heterogeneity analysis reveals that NTU’s carbon abatement effect is more pronounced in resource-based cities, old industrial areas, and cities with lower urbanization levels and higher innovation levels. Mechanism analysis shows that improving urban technological innovation and optimizing resource allocation are important paths for realizing urban CO2 emission reduction. NTU’s effect on urban CO2 emissions has a noticeable spatial spillover. Our findings provide policy makers with solid support for driving high-quality urban development and dual-carbon targets.
On Farmland and Floodplains—Modeling Urban Growth Impacts Based on Global Population Scenarios in Pune, India
Authors: Karutz Raphael , Klassert Christian J. A. , Kabisch Sigrun
Published: May 2023

Emerging megacities in the global south face unprecedented transformation dynamics, manifested in rapid demographic, economic, and physical growth. Anticipating the associated sustainability and resilience challenges requires an understanding of future trajectories. Global change models provide consistent high-level urbanization scenarios. City-scale urban growth models accurately simulate complex physical growth. Modeling approaches linking the global and the local scale, however, are underdeveloped. This work introduces a novel approach to inform a local urban growth model by global Shared Socioeconomic Pathways to produce consistent maps of future urban expansion and population density via cellular automaton and dasymetric mapping. We demonstrate the approach for the case of Pune, India. Three scenarios are explored until 2050: business as usual (BAU), high, and low urbanization. After calibration and validation, the BAU scenario yields a 55% growth in Pune’s population and 90% in built-up extent, entailing significant impacts: Pune’s core city densifies further with up to 60,000 persons/km2, adding pressure to its strained infrastructure. In addition, 66–70% more residents are exposed to flood risk. Half of the urban expansion replaces agriculture, converting 167 km2 of land. The high-urbanization scenario intensifies these impacts. These results illustrate how spatially explicit scenario projections help identify impacts of urbanization and inform long-term planning.
Correction: Xiao et al. An Assessment of the Rational Range of Eco-Compensation Standards: A Case Study in the Nujiang Prefecture, Southwestern China. Land 2022, 11, 1417
Authors: Xiao Weidong , Qu Liquan , Li Kai , Guo Chuanxu , Li Jie
Published: May 2023

In the original publication [...]
The Effect of Policy and Technological Innovations of Land Tenure on Small Landholders’ Credit-Worthiness: Evidence from Ethiopia
Authors: Abab Shewakena Aytenfisu , Senbeta Feyera , Negash Tamirat Tefera
Published: May 2023

Since the early 2000s, Ethiopia has been implementing one of the largest land certification and digitalization programs in Africa, underpinned by technological and policy innovations. The reform indicates a promising avenue for increasing the collateralization of land use rights for smallholder households who have been credit constrained. However, there is scant evidence to what extent these reforms have influenced access to credit. To help generate new insights and fill this gap, the study employed administrative data generated from 11 districts’ digital land registers, survey data from 2296 households in 19 districts, key informant interviews, and policy and legal framework review. Descriptive and inferential statistics complemented by qualitative explanations are employed to analyze the results of the study. The results revealed that accessibility of information from the digital rural land registers increased the credit-worthiness of small landholders and reduced transaction costs and risks. The reform related to collateralization of land use rights also incentivizes financial institutions to establish new loan products for small landholders. The study concludes that while the two-stage land certification programs allow smallholders to possess documented land rights, their credit-worthiness may likely remain negligible without further technological and policy innovations. This implies two policy issues: the need to reform secured transaction laws and digitalizing registries for higher land rights trade ability.
Evidences of Soil Consumption Dynamics over Space and Time by Data Analysis in a Southern Italy Urban Sprawling Area
Authors: Ricca Nicola , Guagliardi Ilaria
Published: May 2023

A qualitative and quantitative deterioration of natural environments occurred recently worldwide. Loss of ecological capacities and agricultural decline are the critical consequences of urbanisation. This paper focuses on the value of assessing the urban sprawl in a southern Italy territory in order to evaluate the significant landscape transformations and provide a document to local administrators for a more balanced management of land use. The importance to calculate the soil consumption dynamics is remarkable in the investigated territory, Rende municipality in the Calabria region, southern Italy, since it is characterized by the same human pressure that occurred in other Mediterranean areas, so it is well representative of wider territories included in the Mediterranean setting. The transition from rural areas to urban settlements has been investigated via landscape analysis, and conducted for spatial and temporal changes over 25 years. The landscape analysis has integrated data from the orthophotos and Esri topographic base map. Quantitatively, the estimation of urban growth, in all its components, and soil consumption are evident by analysis of the number of patches. Qualitatively, the occurred consumption of fertile soil has caused a significant impact on local environmental conditions and on human activities resulting in decreasing of arable land, which decreased significantly over the considered period. This study addresses how knowledge of the change in urban areas is needed to effectively manage urban environmental impacts.
Spatio-Temporal Patterns of Warm-Season Ground Surface Temperature—Surface Air Temperature Difference over China Mainland
Authors: Long Yiwen , Ren Guoyu
Published: May 2023

Examining large-scale characteristics of the difference between ground surface temperature (GST) and surface air temperature (SAT) and its long-term trend will help understand land surface energy exchange and the effect of land-atmosphere interaction on climate change and variability. Based on a homogenized monthly dataset of GST and SAT from 1961 to 2018, this study analyzes the spatial distribution and long-term trend of the difference between ground surface temperature and surface air temperature (GST–SAT) in the warm season (April to October) over China mainland. The results show that the warm-season mean GST–SAT in the Qinghai-Tibet Plateau and the northwestern deserts have the largest GST–SAT. On average, the GST–SAT in China is the greatest in summer, with the maximum monthly value occurring in July. During 1961–2018, the warm-season mean GST–SAT undergoes a significant increasing trend (0.04 °C/10yr, p < 0.01), with the largest increase seen in mid-late spring (April and May), and the smallest increase in August. Spatially, the GST–SAT increases significantly in the northern region, decreases slightly in the southern region, and remains unchanged in the Qinghai-Tibet Plateau. The warm-season mean GST–SAT is significantly positively correlated with altitude and sunshine duration (R = 0.50, 0.40; p < 0.05), and significantly negatively correlated with relative humidity and precipitation (R = 0.48, −0.42; p < 0.05), in the country on a whole in the analysis period.
Eco–Environmental Effects of “Production–Living–Ecological” Space Land Use Changes and Recommendations for Ecological Restoration: A Case Study of the Weibei Dryland in Shaanxi Province
Authors: Jin Junfang , Yin Shuyan , Yin Hanmin , Bai Xin
Published: May 2023

As eco–environmental effects have become important considerations in the construction and planning of production, living, and ecological spaces, we used a combination of quantitative and qualitative methods to analyze the eco–environmental effects’ spatiotemporal evolution and present appropriate ideas for ecological restoration based on the land use data. The results show that during the research period both an improvement and degradation of the regional eco–environment occurred simultaneously. In the earlier period, the ecological environment tended to be worse, while in the later period, the eco–environmental quality was dramatically enhanced. Pasture ecological land in the study area had the strongest positive impact on the eco–environmental quality, while the negative effect of agricultural production land was severe. The quality of the regional eco−environment was enhanced (degraded) due to the extension (contraction) of ecological land. The construction of an ecological environment is a complex engineering task. Although the eco−environment in most areas of the study area showed an improving trend, the overall eco–environment remains relatively fragile. In the course of supporting high–quality regional social and economic growth and pursuing high–level environmental preservation strategies, we should take corresponding measures to protect and repair the regional ecological environment.
Temporomandibular Joint Involvement in Juvenile Idiopathic Arthritis: The Results from a Retrospective Cohort Tertial Center Study
Authors: Artamonov Artem , Kaneva Maria , Gordeeva Natalia , Sorokina Lubov , Kostik Mikhail
Published: May 2023

Our study aimed to evaluate the clinical and laboratory features of juvenile idiopathic arthritis (JIA) children with temporomandibular joint (TMJ) arthritis. In the retrospective cohort study, we analyzed data of 753 patients with JIA aged 2–17 years, depending on TMJ arthritis or not. TMJ arthritis can to be diagnosed in the presence of at least two of the following clinical signs of inflammation: pain in TMJ, jaw opening limitation, jaw opening deviation, and micrognathia. We compared clinical, laboratory, and treatment features in JIA patients depending on the involvement of TMJ. TMJ arthritis was detected in 43 (5.7%) of our patients and associated with a longer course of the disease, polyarticular JIA category, treatment with systemic corticosteroids, and longer achievement of the remission and involvement of cervical spine, hip, and shoulder. Active joints >8 (OR = 14.9, p = 0.0000001), delayed remission >7 years (OR = 3.1; p = 0.0004), delayed hip involvement (OR = 4.6; p = 0.041), hip osteoarthritis (OR = 4.0; p = 0.014), cervical spine arthritis (OR = 10.3, p = 0.000001), and corticosteroid treatment (OR = 2.3, p = 0.0007) were associated with TMJ involvement. Patients with TMJ arthritis require more biologics (OR = 3.2, p = 0.0006, HR = 2.4, p = 0.005) and have decreased probability of remission achievement (p = 0.014). Consequently, TMJ arthritis was associated with a severe disease course. Early biologic treatment and corticosteroid avoidance might decrease TMJ involvement.
Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of Ajuga iva (L.)
Authors: Saidi Soukaina , Remok Firdaous , Handaq Nadia , Drioiche Aziz , Gourich Aman Allah , Menyiy Naoual El , Amalich Smail , Elouardi Mohamed , Touijer Hanane , Bouhrim Mohamed , Bouissane Latifa , Nafidi Hiba-Allah , Bin Jardan Yousef A. , Bourhia Mohammed , Zair Touriya
Published: May 2023

In Morocco, many applications in ethnomedicine on Ajuga iva (L.) have been recognized as able to treat various pathologies such as diabetes, stress, and microbial infections. The objective of this work is to carry out phytochemical, biological, and pharmacological investigations on the extracts of Ajuga iva leaves in order to confirm its therapeutic effects. The phytochemical screening carried out on the different extracts of Ajuga iva showed its richness in primary (lipids and proteins) and secondary metabolites (flavonoids, tannins, reducing compounds, oses, and holoside. The best contents of polyphenols, flavonoids, and tannins evaluated by spectrophotometric methods were found in the hydroethanolic extract (69.850 ± 2.783 mg EAG/g DE, 17.127 ± 0.474 mg EQ/g DE, 5.566 ± 0.000 mg EQC/g DE), respectively. Analysis of the chemical composition of the aqueous extract by LC/UV/MS revealed 32 polyphenolic compounds including ferulic acid (19.06%), quercetin (10.19%), coumaric acid (9.63%), and apigenin-7-(2-O-apiosylglucoside) (6.8%). The antioxidant activity of Ajuga iva extracts was evaluated by three methods (DPPH*, FRAP, CAT). The hydroethanolic extract recorded the strongest reducing power: DPPH* (IC50 = 59.92 ± 0.7 µg/mL), FRAP (EC50 = 196.85 ± 1.54 (µg/mL), and CAT (199.21 ± 0.37 mg EAG/gE). A strong correlation between phenolic compounds and antioxidant activities was confirmed by the determination of Pearson’s coefficient. The antimicrobial activity of Ajuga iva studied by the microtiter method revealed potent antifungal and antibacterial qualities against Candida parapsilosis and Staphylococcus aureus BLACT. An in vivo oral glucose tolerance test (OGTT) using normal rats revealed that the antihyperglycemic action of the aqueous extract significantly reduced postprandial hyperglycaemia at (30 min, p < 0.01) and area under the curve (AUC glucose), p < 0.01. Similarly, the aqueous extract, tested on pancreatic α-amylase enzyme activity in vitro and in vivo significantly inhibited pancreatic α-amylase activity with IC50 = 1.52 ± 0.03 mg/mL. In conclusion, the extract from Ajuga iva could be a good source of bioactive molecules, which exhibit potent antioxidant and antimicrobial activity, as well as strong antidiabetic activity, for applications in the pharmaceutical industry.
Phytochemical Composition, Bioactive Compounds, and Antioxidant Properties of Different Parts of Andrographis macrobotrys Nees
Authors: Dalawai Dayanand , Murthy Hosakatte Niranjana , Dewir Yaser Hassan , Sebastian Joseph Kadanthottu , Nag Anish
Published: May 2023

Andrographis macrobotrys Nees is an ethnomedicinal plant belonging to the family Acanthaceae, distributed in the moist deciduous and semi-evergreen forests of the southern Western Ghats of India. The objective of this research was to determine the phytochemical composition and bioactive chemical components using gas chromatography and mass spectrometry (GC-MS) and to check the antioxidant potential of the plant part extracts. A. macrobotrys roots, stems, and leaves were obtained from the species’ natural habitat in the Western Ghats, India. The bioactive compounds were extracted using a Soxhlet extractor at 55–60 °C for 8 h in methanol. Identification analysis of A. macrobotrys bioactive compound was performed using GC-MS. Quantitative estimation of phytochemicals was carried out, and the antioxidant capacity of the plant extracts was determined by 2,2′-diphenyl-1-picrylhydrazyl radical scavenging (DPPH) and ferric reducing assays (FRAP). A. macrobotrys has a higher concentration of phenolics in its stem extract than in its root or leaf extracts (124.28 mg and 73.01 mg, respectively), according to spectrophotometric measurements. GC-MS analysis revealed the presence of phytochemicals such as azulene, 2,4-di-tert-butylphenol, benzoic acid, 4-ethoxy-ethyl ester, eicosane, 3-heptadecanol, isopropyl myristate, hexadecanoic acid methyl ester, hexadecanoic acid, 1-butyl-cyclohexanol, 9,12-octadecadienoic acid, alpha-monostearin, and 5-hydroxy-7,8-dimethoxyflavone belonging to various classes of flavonoids, terpenoids, phenolics, fatty acids, and aromatic compounds. Significant bioactive phytochemicals include 2,4-di-tert-butylphenol, 2-methoxy-4-vinylphenol, 5-hydroxy-7,8-dimethoxyflavone, azulene, salvigenin, squalene, and tetrapentacontane. In addition, the antioxidant capability of each of the three extracts was assessed. The stem extract demonstrated impressive DPPH scavenging and ferric reduction activities, with EC50 values of 79 mg/mL and 0.537 ± 0.02 OD at 0.2 mg/mL, respectively. The results demonstrated the importance of A. macrobotrys as a source of medicine and antioxidants.
Vascular Diseases: Etiologic, Diagnostic, Prognostic, and Therapeutic Research
Authors: Olinic Dan Mircea , Stanek Agata
Published: May 2023

The impacts of vascular diseases (VD) include increased morbidity and mortality, which are related to factors such as population aging, socio-economics, or an increasing prevalence of risk factors, e [...]
Exploring the Potential of Transcranial Direct Current Stimulation for Relieving Central Post-Stroke Pain: A Randomized Controlled Pilot Study
Authors: Baik Ji-Soo , Yang Jung-Hyun , Ko Sung-Hwa , Lee So-Jung , Shin Yong-Il
Published: May 2023

The potential of transcranial direct current stimulation (tDCS) as a non-invasive brain stimulation technique for treating pain has been studied. However, its effectiveness in patients with central post-stroke pain (CPSP) and the impact of lesion location remain unclear. This study investigated tDCS’s pain reduction effects in patients with CPSP. Twenty-two patients with CPSP were randomized into the tDCS or sham groups. The tDCS group received stimulation of the primary motor cortex (M1) for 20 min, five times weekly, for two weeks, and underwent evaluations at baseline, immediately after the intervention, and one week after the intervention. The tDCS group had no significant improvement compared to the sham group in pain, depression, and quality of life. Nevertheless, significant changes were identified within the tDCS group, and the pain trends appeared to be influenced by the lesion location. These findings provide important insights into the use of tDCS in patients with CPSP, which could inform further research and development of pain treatment options.
Andrographis paniculata (Burm.f.) Nees Alleviates Methotrexate-Induced Hepatotoxicity in Wistar Albino Rats
Authors: Parthasarathy Manisha , Prince Sabina Evan
Published: May 2023

Andrographis paniculata is a herbal plant used in traditional medicinal approaches to treat various ailments and diseases. Methotrexate (MTX) is a clinically used immunosuppressant and anticancer drug. One of the increasing concerns with MTX use is liver toxicity. The aim of this study is to investigate the potential effect of aqueous leaf extract of Andrographis paniculata against methotrexate-induced hepatotoxicity. Wistar albino rats were grouped into five groups, and the drugs were administered. MTX (20 mg/kg b.w.) was intraperitoneally injected into rats on the ninth day alone. Aqueous leaf extract of Andrographis paniculata (500 mg/kg b.w./day) was orally administered for 10 days. We confirmed the beneficial effect of aqueous extracts of Andrographis paniculata on restoring the hepatic enzyme markers, lipid profile, antioxidant level, anti-inflammatory marker (IL-10), anti-apoptosis (bcl-2), significant suppression of inflammatory cytokines (TNF-α, and IL-6), apoptosis marker (caspase 3) and cellular tissue damage caused by MTX. Overall, we revealed that Andrographis paniculata reduces critical aspects of oxidative stress, inflammatory processes, and apoptosis, thus protecting against methotrexate-induced hepatotoxicity.
Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease
Authors: Gonçalves Anderson Cesar , de Faria Oliveira Isabelle Stefan , Hamamoto Filho Pedro Tadao , Ortolan Erika Veruska Paiva , Terra Simone Antunes , Rodrigues Maria Aparecida Marchesan , de Arruda Lourenção Pedro Luiz Toledo
Published: May 2023

Introduction: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity that affects the submucosal nerve plexus of the distal intestine. The lack of definition of the causal relationship between histological findings and clinical symptoms has been identified as the primary point to be elucidated in the scientific investigation related to IND-B, which is essential for it to be considered a disease. Objective: To investigate the relationship between histopathological findings and symptoms in a series of patients with IND-B. Methods: Twenty-seven patients with histopathological diagnosis of IND-B, according to the Frankfurt Consensus (1990), who underwent surgical treatment through colorectal resections were included. Data from medical records regarding the clinical picture of the patients at the time of diagnosis, including the intestinal symptom index (ISI) and a detailed histopathological analysis of the rectal specimens, were retrieved. Exploratory factor analysis was performed, applying the principal components method for clusters with Varimax rotation. Results: Two factors were determined: the first, determined by histopathological and clinical variables, and the second, composed of the main symptoms presented in patients with IND-B, including ISI. Factorial rotation showed the association between the two factors and, through a graph, demonstrated the proximity between ISI values and histopathological alterations. Conclusion: There was evidence of an association between the clinical features presented by patients with IND-B and the histopathological findings of the rectal samples. These results support the understanding of IND-B as a disease.
Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide
Authors: Harrison Stuart A. , Webb William L. , Rammu Hanadi , Lane Nick
Published: May 2023

A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite for the synthesis of many other essential biomolecules. Aspartate’s prebiotic synthesis is complicated by the instability of its precursor, oxaloacetate. In this paper, we show that the use of the biologically relevant cofactor pyridoxamine, supported by metal ion catalysis, is sufficiently fast to offset oxaloacetate’s degradation. Cu2+-catalysed transamination of oxaloacetate by pyridoxamine achieves around a 5% yield within 1 h, and can operate across a broad range of pH, temperature, and pressure. In addition, the synthesis of the downstream product β-alanine may also take place in the same reaction system at very low yields, directly mimicking an archaeal synthesis route. Amino group transfer supported by pyridoxal is shown to take place from aspartate to alanine, but the reverse reaction (alanine to aspartate) shows a poor yield. Overall, our results show that the nodal metabolite aspartate and related amino acids can indeed be synthesised via protometabolic pathways that foreshadow modern metabolism in the presence of the simple cofactor pyridoxamine and metal ions.
Rare Causes of Cerebral Venus Sinus Thrombosis: A Systematic Review
Authors: Theologou Rafaella , Nteveros Antonios , Artemiadis Artemios , Faropoulos Konstantinos
Published: May 2023

Background: Cerebral venous sinus thrombosis (CVST) is a rare manifestation of thrombosis commonly caused by thrombophilia, hormonal-related factors, non-cerebral malignancy, and hematologic diseases. The aim of this review was to identify and summarize rare CVST cases. Methods: A literature search of the Medline database was performed in November 2022. CVST cases of a common cause were excluded. Demographic and clinical data were extracted. Eligible cases were categorized into inflammatory, primary CNS tumors, post-operative/traumatic, and idiopathic groups to allow statistical group comparisons. Results: 76 cases were analyzed. Idiopathic CVST was most frequently reported followed by inflammatory, post-traumatic/operative and primary CNS tumor causes. The intracranial hemorrhage rate was 23.7% and it was found to increase in the inflammatory group (45.8%). Anticoagulation was used in the majority of cases and it was significantly related to better outcomes. A low rate of anticoagulation use (43.8%) was found among CVST cases in the post-operative/traumatic group. The overall mortality rate was 9.8%. 82.4% of patients showed significant early improvement. Conclusions: Most rare CVST cases were either of idiopathic or inflammatory origin. Interestingly, hemorrhage occurred often he idiopathic CVST cases. A low rate of anticoagulation use in neurosurgical CVST cases after trauma or head surgery was observed.
Effect of Iron Tailing Powder-Based Ternary Admixture on Acid Corrosion Resistance of Concrete
Authors: Zhang Bing , Zhang Yannian , Liu Wenliang , Gu Xiaowei , Wang Qingjie , Zhang Shaowu , Gao Jian
Published: May 2023

Exposure of concrete to acidic environments can cause the degradation of concrete elements and seriously affect the durability of concrete. As solid wastes are produced during industrial activity, ITP (iron tailing powder), FA (fly ash), and LS (lithium slag) can be used as admixtures to produce concrete and improve its workability. This paper focuses on the preparation of concrete using a ternary mineral admixture system consisting of ITP, FA, and LS to investigate the acid erosion resistance of concrete in acetic acid solution at different cement replacement rates and different water–binder ratios. The tests were performed by compressive strength analysis, mass analysis, apparent deterioration analysis, and microstructure analysis by mercury intrusion porosimetry and scanning electron microscopy. The results show that when the water–binder ratio is certain and the cement replacement rate is greater than 16%; especially at 20%, the concrete shows strong resistance to acid erosion; when the cement replacement rate is certain and the water–binder ratio is less than 0.47; especially at 0.42, the concrete shows strong resistance to acid erosion. Microstructural analysis shows that the ternary mineral admixture system composed of ITP, FA, and LS promotes the formation of hydration products such as C-S-H and AFt, improves the compactness and compressive strength of concrete, and reduces the connected porosity of concrete, which can obtain good overall performance. In general, concrete prepared with a ternary mineral admixture system consisting of ITP, FA, and LS has better acid erosion resistance than ordinary concrete. The use of different kinds of solid waste powder to replace cement can effectively reduce carbon emissions and protect the environment.
Mechanical Spectroscopy Study of CrNiCoFeMn High-Entropy Alloys
Authors: Campari Enrico Gianfranco , Casagrande Angelo
Published: May 2023

The equiatomic high-entropy alloy of composition of CrNiCoFeMn with an FCC crystal structure was prepared by either induction melting or additive manufacturing with a selective laser melting (SLM) process, starting from mechanically alloyed powders. The as-produced samples of both kinds were cold worked, and in some cases re-crystallized. Unlike induction melting, there is a second phase, which is made of fine nitride and Cr-rich σ phase precipitates, in the as-produced SLM alloy. Young’s modulus and damping measurements, as a function of temperature in the 300–800 K range, were performed on the specimens that were cold-worked and/or re-crystallized. Young’s modulus values of (140 ± 10) GPa and (90 ± 10) GPa were measured from the resonance frequency of free-clamped bar-shaped samples at 300 K for the induction-melted and SLM samples, respectively. The room temperature values increased to (160 ± 10) GPa and (170 ± 10) GPa for the re-crystallized samples. The damping measurements showed two peaks, which were attributed to dislocation bending and grain-boundary sliding. The peaks were superposed on an increasing temperature background.
A Polymorph of Dipeptide Halide Glycyl-L-Alanine Hydroiodide Monohydrate: Crystal Structure, Optical Second Harmonic Generation, Piezoelectricity and Pyroelectricity
Authors: Baptista Rosa M. F. , Gomes Clara S. B. , Silva Bruna , Oliveira João , Almeida Bernardo , Castro Cidália , Rodrigues Pedro V. , Machado Ana , Freitas Ruben B. , Rodrigues Manuel J. L. F. , de Matos Gomes Etelvina , Belsley Michael
Published: May 2023

A polymorph of glycyl-L-alanine HI.H2O is synthesized from chiral cyclo-glycyl-L-alanine dipeptide. The dipeptide is known to show molecular flexibility in different environments, which leads to polymorphism. The crystal structure of the glycyl-L-alanine HI.H2O polymorph is determined at room temperature and indicates that the space group is polar (P21), with two molecules per unit cell and unit cell parameters a = 7.747 Å, b = 6.435 Å, c = 10.941 Å, α = 90°, β = 107.53(3)°, γ = 90° and V = 520.1(7) Å3. Crystallization in the polar point group 2, with one polar axis parallel to the b axis, allows pyroelectricity and optical second harmonic generation. Thermal melting of the glycyl-L-alanine HI.H2O polymorph starts at 533 K, close to the melting temperature reported for cyclo-glycyl-L-alanine (531 K) and 32 K lower than that reported for linear glycyl-L-alanine dipeptide (563 K), suggesting that although the dipeptide, when crystallized in the polymorphic form, is not anymore in its cyclic form, it keeps a memory of its initial closed chain and therefore shows a thermal memory effect. Here, we report a pyroelectric coefficient as high as 45 µC/m2K occurring at 345 K, one order of magnitude smaller than that of semi-organic ferroelectric triglycine sulphate (TGS) crystal. Moreover, the glycyl-L-alanine HI.H2O polymorph displays a nonlinear optical effective coefficient of 0.14 pm/V, around 14 times smaller than the value from a phase-matched inorganic barium borate (BBO) single crystal. The new polymorph displays an effective piezoelectric coefficient equal to deff=280 pCN−1, when embedded into electrospun polymer fibers, indicating its suitability as an active system for energy harvesting.
Effects of Heat Input on Weld Microstructure and Properties in Keyhole TIG Welding of Invar 36 Alloy
Authors: Liu Hongbing , Lv Shanhui , Xuan Yang , Oliveira João Pedro , Schell Norbert , Shen Jiajia , Deng Jingyu , Wang Yuhua , Yang Jin
Published: May 2023

The Invar alloy is widely used for aircraft wing mould manufacturing. In this work, keyhole-tungsten inert gas (K-TIG) butt welding was used to join 10 mm thick Invar 36 alloy plates. The effect of heat input on the microstructure, morphology and mechanical properties was studied by using scanning electron microscopy, high energy synchrotron X-ray diffraction, microhardness mapping, tensile and impact testing. It was shown that regardless of the selected heat input, the material was solely composed of austenite, although the grain size changed significantly. The change in heat input also led to texture changes in the fusion zone, as qualitatively determined with synchrotron radiation. With increases in heat input, the impact properties of the welded joints decreased. The coefficient of thermal expansion of the joints was measured, which demonstrated that the current process is suitable for aerospace applications.
Numerical Investigation on the Ballistic Performance of Semi-Cylindrical Nacre-like Composite Shells under High-Velocity Impact
Authors: Yang Huiwei , Gao Dongyang , Chen Pengcheng , Lu Guoyun
Published: May 2023

The nacre has excellent impact resistance performance, and it is attracting attention in the field of aerospace composite research. Inspired by the layered structure from nacre, semi-cylindrical nacre-like composite shells of brittle silicon carbide ceramic (SiC) and aluminum (AA5083-H116) were established. Two types of tablet arrangements (regular hexagonal and Voronoi polygons) of the composites were designed, and the same size of ceramic and aluminum shell were established for the impact resistance analyzed numerically. In order to better compare the resistance performance of the four types of structures under different impact velocity, the following parameters were analyzed including energy variation, damage characteristic, bullet residual velocity, and semi-cylindrical shell displacement. The results show that the semi-cylindrical ceramic shells have higher rigidity and ballistic limit, but the severe vibration after impact causes penetrating cracks, and the whole structure failure occurred eventually. The nacre-like composites have higher ballistic limits than semi-cylindrical aluminum shells, and the impact of bullets only causes local failure. In the same conditions, the impact resistance of regular hexagons is better than Voronoi polygons. The research analyzes the resistance characteristic of nacre-like composites and single materials, and provides a reference for the design of nacre-like structures.
A Hybrid Damper with Tunable Particle Impact Damping and Coulomb Friction
Authors: Akbar Muhammad Ayaz , Wong Wai-On , Rustighi Emiliano
Published: May 2023

A particle impact damper (PID) dissipates the vibration energy of a structure through impacts within the damper. The PID is not commonly used in practice mainly because of its low damping-to-mass ratio and the difficulty in achieving its optimal design due to its nonlinear characteristics. In contrast, a Coulomb friction damper (FD) can offer a higher damping force-to-mass ratio than other dampers, but it is also difficult to be controlled precisely due to its nonlinear characteristics and excessive frequency sensitivity regarding the resonant frequency. This paper examines a hybrid damper by combining a particle impact damper and a Coulomb friction damper (PID + FD) theoretically and experimentally. A theoretical model of the proposed damper is developed and tested numerically on a single-degree-of-freedom (SDOF) structure. The predicted results are validated by experimental tests on a prototype of the proposed damper. The damping force provided by the FD in the prototype can be varied by adjusting the normal force applied through a compression spring, while the vibration energy dissipation by the PID can be varied by changing the cavity size of the PID. A parametric analysis of the proposed hybrid damper has been performed. The proposed hybrid damper can reduce the maximum vibration amplitude of the SDOF primary structure by 66% and 43% compared with using the FD and PID only. The proposed damper is found to be effective over a wide range of excitation frequencies. Furthermore, the proposed hybrid damper achieves a similar vibration suppression performance to the traditional tuned mass damper (TMD) of a similar mass ratio. The proposed damper does not require an optimally tuned natural frequency and damping, unlike the TMD, and therefore it does not have the detuning problem associated with the TMD. In addition, the performance of the proposed damper is tested and compared with the TMD for random earthquake excitation data. Consequently, the proposed hybrid damper may be a simpler and better alternative to the TMD in passive vibration control applications.
The Transverse Vibration Characteristics of Circular Saw Blade on Mobile Cantilever-Type CNC Sawing Machine
Authors: Yan Xinyu , Cui Yunqi , Qiu Hongru , Ding Tao , Zhu Nanfeng , Wang Baojin
Published: May 2023

A circular saw blade is a commonly used tool in wood processing. The transverse vibration of the saw blade plays an important role in processing quality during cutting and affects its service life as well. In the study, the transverse vibration of the circular saw blade was investigated at the constant rotation by the simulation using ANSYS software when changing the cantilever length of the cantilever woodworking CNC circular saw machine. Meanwhile, the transverse vibration of the circular saw blade without and with load was explored by the eddy current sensors for when the detection point was differently away from the center of the circular saw blade. The time domain, probability density distribution, and power spectrum characteristics of the transverse vibration signal were analyzed, and the simulation values were compared with the actual cutting data. The results revealed that under certain conditions, the maximum transverse vibration value of the circular saw blade was the smallest in the simulation, then the middle in no-load, and the largest in actual cutting. The maximum transverse vibration value of the saw blade was increased with the extension of the cantilevered overhang, but gradually and slightly, indicating the transverse vibration was hardly affected by the change in overhang length of less than 300 mm. The finding provides the reference for the structural optimization design of cantilever CNC circular saw machines and the promotion of its application.
Industrial and Management Applications of Type-2 Multi-Attribute Decision-Making Techniques Extended with Type-2 Fuzzy Sets from 2013 to 2022
Authors: Aleksić Aleksandar , Tadić Danijela
Published: May 2023

The ongoing research in the field of decision-making can be analyzed from different perspectives. Research trends indicate that multi-attribute decision-making (MADM) methods have a significant impact on engineering and management scientific areas. Since many of the problems existing in the mentioned areas are associated with a certain level of uncertainty, type 2 fuzzy sets represent a common solution for the enhancement of conventional MADM methods. In this way, the decision-makers are encouraged to use linguistic expressions for the assessment of attributes’ relative importance and their values. The purpose of this paper is to review a determination of attributes’ relative importance, and their values, as well as the extension of ranking methods with type 2 fuzzy sets. The papers are systematically adjoined to groups consisting of hybrid models with the following characteristics: (1) indicating the procedure for modeling attribute relative importance and their values, (2) determining the extension of MADM methods with type 2 fuzzy sets to determine attributes’ vector weights, and (3) the extension of MADM for attributes ranking with type 2 fuzzy sets. This study reviewed a total of 42 papers in the domain of engineering and management published from 2013 to 2023 in different journals indexed by the Springer, Science Direct, Emerald, Wiley, ProQuest, Taylor, and Francis research platforms.
Trends in Agroforestry Research from 1993 to 2022: A Topic Model Using Latent Dirichlet Allocation and HJ-Biplot
Authors: Montes-Escobar Karime , De la Hoz-M Javier , Barreiro-Linzán Mónica Daniela , Fonseca-Restrepo Carolina , Lapo-Palacios Miguel Ángel , Verduga-Alcívar Douglas Andrés , Salas-Macias Carlos Alfredo
Published: May 2023

Background: There is an immense debate about the factors that could limit the adoption of agroforestry systems. However, one of the most important is the generation of scientific information that supports the viability and benefits of the proposed techniques. Statistical analysis: This work used the Latent Dirichlet Allocation (LDA) modeling method to identify and interpret scientific information on topics in relation to existing categories in a set of documents. It also used the HJ-Biplot method to determine the relationship between the analyzed topics, taking into consideration the years under study. Results: A review of the literature was conducted in this study and a total of 9794 abstracts of scientific articles published between 1993 and 2022 were obtained. The United States, India, Brazil, the United Kingdom, and Germany were the five countries that published the largest number of studies about agroforestry, particularly soil organic carbon, which was the most studied case. The five more frequently studied topics were: soil organic carbon, adoption of agroforestry practices, biodiversity, climatic change global policies, and carbon and climatic change. Conclusion: the LDA and HJ-Biplot statistical methods are useful tools for determining topicality in text analysis in agroforestry and related topics.
An Optimal Inequality for the Normal Scalar Curvature in Metallic Riemannian Space Forms
Authors: Uddin Siraj , Choudhary Majid Ali , Al-Asmari Najwa Mohammed
Published: May 2023

In this paper, we prove the DDVV conjecture for a slant submanifold in metallic Riemannian space forms with the semi-symmetric metric connection. The equality case of the derived inequality is discussed, and some special cases of the inequality are given.
Schur Complement-Based Infinity Norm Bound for the Inverse of Dashnic-Zusmanovich Type Matrices
Authors: Zeng Wenlong , Liu Jianzhou , Mo Hongmin
Published: May 2023

It is necessary to explore more accurate estimates of the infinity norm of the inverse of a matrix in both theoretical analysis and practical applications. This paper focuses on obtaining a tighter upper bound on the infinite norm of the inverse of Dashnic–Zusmanovich-type (DZT) matrices. The realization of this goal benefits from constructing the scaling matrix of DZT matrices and the diagonal dominant degrees of Schur complements of DZT matrices. The effectiveness and superiority of the obtained bounds are demonstrated through several numerical examples involving random variables. Moreover, a lower bound for the smallest singular value is given by using the proposed bound.