bluuebunny/crossref_metadata_2025 huggingface dataset:
The Framework of Cloud Business Process Management Model
Authors: Bitkowska Agnieszka , Dziembek Damian , Gzik Tomasz
Published: September 2024

Business Process Management faces many barriers. Some of them are related to employee resistance to change, poor decision-making, lack of adequate IT systems, limitations of the IT solutions they have or financial constraints. Cloud computing, due to its properties of economic, organizational, managerial and technical nature, can help overcome the difficulties of Business Process Management both at the stage of implementation and execution. The analysis of the literature indicates the existence of ambiguity of concepts and the lack of indication of how to manage business processes using the cloud in practice. In response to this, the Framework of BPM Model based on Cloud Computing was developed and subjected to preliminary verification with the participation of experts from the Polish insurance and financial market. The Framework is the own concept that addresses both theoretical and practical aspects of Business Process Management based on Cloud Computing. The purpose of the Framework in a scientific perspective is to establish nomenclature and definitions and to define an approach to BPM using Cloud Computing. In the practical perspective, the final goal is to support management practitioners by showing how to organize, how to implement and how to execute BPM based on Cloud Computing. The article presents the features, assumptions, structure, directions of the Framework development and the results of its preliminary verification.
PERSEPSI MANAJEMEN BUMD TERHADAP PRAKTIK PENGAWASAN OLEH DEWAN PENGAWAS ATAU KOMISARIS BUMD KABUPATEN GARUT
Authors: Fajarwati Fenty , Shodiqun Muhamad
Published: September 2024

Penelitian ini bertujuan untuk menganalisis pengaruh persepsi manajemen terhadap praktik pengawasan oleh dewan pengawas atau komisaris BUMD Kabupaten Garut. Populasi pada penelitian ini adalah pegawai level menegah dan atas dari BUMD Kabupaten Garut dan sampel yang digunakan sebanyak 40 orang. Metode penelitian ini dapat dikategorikan penelitian kuantitatif dengan menggunakan alat analisis SMARTPLS Versi 4. Hasil penelitian menunjukkan bahwa persepsi manajemen berpengaruh terhadap praktik pengawasan oleh dewan pengawas atau komisaris BUMD Kabupaten Garut.
Loncastuximab tesirine in Chinese patients with relapsed or refractory diffuse large B-cell lymphoma: a multicenter, open-label, single-arm, phase II trial
Authors: Lin Ningjing , Sun Xiuhua , Zhou Hui , Zou Liqun , Zhou Keshu , Liu Lihong , Yang Haiyan , Hu Kai , Cai Qingqing , Liu Yao , Jin Jie , Zhang Liling , Li Wenyu , Guo Ye , Yang Wei , Luo Feng , Wang Zhenguang , Zhu Rong , Yang Lei , Song Dan , Song Yuqin , Zhu Jun
Published: September 2024

Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Loncastuximab tesirine (Lonca), an antibody conjugate targeting CD19, has demonstrated significant clinical benefit in R/R DLBCL in a global phase 2 LOTIS-2 study. In the China bridging pivotal phase 2 OL-ADCT-402-001 study, eligible patients aged ≥18 years with R/R DLBCL who had failed ≥ 2 lines of systemic therapies were enrolled and treated with Lonca every 3 week with 150 μg/kg for 2 cycles; then 75 μg/kg for subsequent cycles (up to 1 year). The primary endpoint was overall response rate (ORR) assessed by independent review committee. Primary analyses for efficacy and safety were performed on the patients who received at least one treatment and had at least 6 months of follow-up following an initial documented response. As of data-cutoff, 64 patients received Lonca (median: 4.0 cycles [range: 1 to 17]). The median number of prior lines of therapies was 3.0 (range: 2 to 12). The ORR was 51.6% (95% CI: 38.7% to 64.2%), and the complete response rate was 23.4%. Hematological events accounted for the majority of the most common (≥15%) Grade ≥3 treatment-emergent adverse events (TEAEs), in which increased gamma glutamyltransferase (25.0%), and hypokalaemia (18.8%) also were reported. Serious TEAEs were reported in 35 of 64 patients with 4 fatal TEAEs. In conclusion, Lonca monotherapy demonstrated clinically meaningful efficacy and was well-tolerated in heavily pretreated Chinese patients with R/R DLBCL, which was consistent with the results of the LOTIS-2 study in Caucasian patients.
Blinatumomab is associated with better post-transplant outcome than chemotherapy in children with high-risk first-relapse B-cell acute lymphoblastic leukemia irrespective of the conditioning regimen
Authors: Peters Christina , Bruno Angela , Rizzari Carmelo , Brescianini Alessandra , Von Stackelberg Arend , Linderkamp Christin , Zeng Yi , Zugmaier Gerhard , Locatelli Franco
Published: September 2024

Not available.
Sociodemographic and Perinatal Risk Factors for Autism Spectrum Disorder: A Case-control Study
Authors: Syfullah Khalid Ahmed , Tayeb Ali Golam Mohammad , Arjumand Merina , Hossain Md Monir , Ahmed Gias Uddin , Pervez Abu Faisal Md , Hossain Mohammad Neamat , Hasan A N M Saiful
Published: September 2024

Autism spectrum disorders included impaired communication and social interaction with restricted and repetitive interests and behaviors. The rising prevalence, coupled with the severe emotional and financial impact on the families, underscores the need for a particular emphasis on the prevention of autism spectrum disorder. However, risk factors for autism have not been well studied in Bangladesh. To describe the sociodemographic and perinatal aspects of a group of Bangladeshi autistic children in order to determine its possible risk factors.This case-control study was conducted at two specialized centers at Chattogram, Bangladesh, from January 2017 to December 2017. We selected 100 autistic children aged more than three years as cases and 100 age, sex-matched children without autism as control for the study. Sociodemographic and perinatal data were collected by direct interviewing of the parents of the children and reviewing the available records. We found higher maternal education and higher maternal age (≥35 years) at birth among autistic children in comparison to the controls (18% and 17% vs. 3% and 6% respectively). Higher paternal age (≥35 years) at birth and monthly family income ≥40000 Taka were found in 26% and 42% of autistic children than 23% and 7% in the control group. Perinatal asphyxia , preterm delivery, low birth weight, and gestational diabetes mellitus were associated with an increased risk of autism. Monthly family income, prematurity, and perinatal asphyxia were independent predictive factors as derived by logistic regression analysis. Higher socioeconomic status, prematurity, and perinatal asphyxia were found to be posing a significant risk to the development of autism.
Bangabandhu Sheikh Mujib Med. Coll. J. 2024;3(2):63-69
Endoscopic Evaluation of Upper Gastrointestinal Bleeding in Liver Cirrhosis
Authors: Kabir Mohammad Rafiqul , Masud Mahadi , Sharifunnesa  , Karmaker Partha Pratim , Arif Mostafa , Talukder Nazir Uddin , Islam M M Shahin Ul
Published: September 2024

Liver cirrhosis is a common, often progressive and usually fatal disorder. Upper gastrointestinal (UGI) bleeding is a leading cause of death in patient with cirrhosis. In this observational study, 50 patients were included according to selection criteria. Maximum participants (40%) were in the age group of 40-50 years of age (Mean ± SD = 42.94 ± 9.72, Minimum = 20 and Maximum = 62). Male were 68% and female were 32%. Male were more sufferer than female. Overall male to female ratio were 3:1. Esophageal varies was the commonest cause of haematemesis and melaena followed by portal hypertensive gastropathy, duodenal ulcer, gastric ulcer, erosive gastritis and reflux oesophagitis in patient with liver cirrhosis. Oesophageal varices were found in 60% participants. There were no gastric varices found among the participants. Presence of Portal HTN gastropathy was in 14% patients. Gastric ulcer was found in only 6% patients, 10% patients had duodenal ulcer, 3 (6%) patients had reflux oesophagitis, erosive gastritis was also present in 3(6%) of participants. Haematemesis, melaena and both haematemesis and melaena were noted in 24%, 22% and 54% of the patients respectively. HBsAg was positive in 50% patient. HCV was positive among 18% patients.
Bangabandhu Sheikh Mujib Med. Coll. J. 2024;3(2):74-78
Assessment of Sensitivity and Specificity of CEA in Primary Diagnosis of patients with Gastrointestinal Malignancy
Authors: Khan Saiful Islam , Md Shafiqul Islam  , Quazi Mehranuddin Ahmed  , Mostak Ahmed  , Md Sidur Rahman Mollah  , Sharif Jayad Atique  , Md Tofazzal Hussain  , Rifat Subrina Anna  , ASM Tanjilur Rahman  , Ratan Kumar Saha
Published: September 2024

Primary Diagnosis of GI (gastrointestinal) malignancy is difficult and most of the diagnostic tools were costly and invasive. The clinical validity of monitoring the serum biomarker carcinoembryonic antigen (CEA) was assessed in 100 patients with gastric, duodenal and colorectal adenocarcinomas in a tertiary-level hospital in Bangladesh. Sensitivity and specificity of the test were evaluated preoperatively. Patients were assessed clinically, radiologically, and biochemically. Our study revealed that in gastrointestinal (GI) malignancy as a whole the CEA test had a preoperative sensitivity and specificity of 54% and 80%, respectively. In stomach cancer, the sensitivity and specificity of CEA were 33.33% and 100%, respectively. In duodenal adenocarcinoma and carcinoma of caecum, the sensitivity and specificity of CEA were 66.67% and 40.0%, respectively. In colonic cancer, the sensitivity and specificity of CEA were 42.86% and 60.0%, respectively. In rectal carcinoma, the sensitivity and specificity of CEA were 42.86% and 63.64%, respectively. All these values are not statistically significant. So for detecting GI malignancies, the use of CEA is not widely recommended due to its low sensitivity and high specificity. An additional finding was that serum CEA levels were significantly elevated in advanced stages of gastrointestinal (GI) malignancy, with the highest levels observed in stage D (100%) followed by stage C (92.3%) and stage B (32.3%).
Bangabandhu Sheikh Mujib Med. Coll. J. 2024;3(2):70-73
Splenic Pregnancy: A Diagnostic Dilemma
Authors: Alam Samiya , Saha Ratan Kumar , Begum Zakia , Akhter Parul , Naher Badrun , Hussain Md Tofazzal , Shanta Ismat Ara
Published: September 2024

Pregnancy in spleen is an infrequent incidence. Hence its outcome is meant to be much more alarming when it ruptures than usual site tubal ectopic. A 29 years old woman presented at her 9 weeks of gestation with loose motion and repeated vomiting. She had a previous history of ectopic pregnancy. She confirmed her pregnancy by urinary strip test but no Ultrasonogram was done. She was received in a state of shock. Ultrasonography revealed abdominal collection and βHCG was raised. Laparotomy was done as a case of tubal ruptured ectopic. Surprisingly ectopic site was in the spleen and splenectomy was done. A number of case reports and literature review are discussed to explore how the splenic ectopic pregnancy present, how these cases are managed and what could be done to alleviate this misery.
Bangabandhu Sheikh Mujib Med. Coll. J. 2024;3(2):113-116
Cover Page July 2024
Authors: Islam M M Shahin Ul
Published: September 2024

Abstract not available
Bangabandhu Sheikh Mujib Med. Coll. J. 2024;3(2): I
List of Contents July 2024
Authors: Islam M M Shahin Ul
Published: September 2024

Abstract not available
Bangabandhu Sheikh Mujib Med. Coll. J. 2024;3(2): II
Pemanfaatan TTG Mesin Grinder dalam Proses Pengolahan Jagung Menjadi Menir untuk Meningkatkan Nilai Ekonomi Hasil Pertanian dan Peternakan Unggas
Authors: Yoto Yoto , Nurhadi Didik , Suyetno Agus , Mawangi Putri Ardista Nursisda , Effendi Muhammad Idris , Maula Putrinda Inayatul
Published: September 2024

Program pengabdian masyarakat ini bertujuan untuk meningkatkan kesejahteraan petani jagung dan peternak unggas di Desa Tempursari melalui penyediaan teknologi tepat guna berupa mesin penggiling jagung. Masalah utama yang dihadapi adalah tingginya harga pakan ternak, terutama jagung menir. Melalui observasi dan wawancara, ditemukan bahwa petani dan peternak belum memiliki pengetahuan dan akses terhadap teknologi penggilingan jagung. Kegiatan pengabdian meliputi pelatihan penggunaan mesin penggiling, demonstrasi, dan serah terima mesin kepada kelompok tani. Hasil evaluasi menunjukkan bahwa mesin ini mampu meningkatkan efisiensi produksi pakan ternak hingga 45%, mengurangi biaya produksi sebesar 30%, dan meningkatkan nilai tambah jagung hingga 25%. Partisipasi aktif masyarakat dalam pelatihan menunjukkan tingginya antusiasme mereka terhadap teknologi baru ini. Kesimpulannya, program pengabdian ini telah berhasil memberikan solusi yang efektif terhadap permasalahan yang dihadapi oleh masyarakat Desa Tempursari. Adanya mesin penggiling jagung diharapkan dapat meningkatkan pendapatan petani dan peternak serta berkontribusi pada pengembangan sektor pertanian di daerah tersebut.
Implementation of Ticket Sanctions for Traffic Violations Based on Law No. 22 of 2009 at the Sorong City Police Traffic Unit
Authors: Massa Ferderika , Wan Norhasniah
Published: September 2024

Traffic violations are one type of offense that is included in certain criminal offenses. In the context of Indonesian law, every offense, whether it is a crime or a violation, must be processed in accordance with the applicable laws. However, there are still many students and people who commit violations such as driving without a driver's license, STNK, violating red lights, and not wearing a helmet. Although the police are responsible for traffic order, often the settlement of violations is not in accordance with the provisions of the law, even settled on the spot by unscrupulous law enforcement officers. Traffic law should create order and freedom for society, by combining the freedom of road users with order. This research aims to explore the application of ticket sanctions against traffic violations based on Law No. 22 of 2009 concerning Road Traffic and Transportation at the Sorong City Police Traffic Unit. The research method used is empirical juridical with descriptive analysis approach. The results showed that the application of ticket sanctions against traffic violations includes various types of sanctions in accordance with the violations committed, such as principal and additional punishment. The application of ticket sanctions is carried out through various stages, including written legal action using ticket stamps. In addition, the research also revealed that minors who commit traffic offenses are enforced with special considerations, taking into account the truth, justice, and welfare of the child. This research underscores the importance of road traffic and transportation in supporting national development and integration, as well as the need to develop its potential and role in realizing traffic safety and order.
MENYELARASKAN KEPENTINGAN POLITIK, BUDAYA, DAN BIROKRASI DALAM PERUMUSAN KEBIJAKAN PERTAHANAN
Authors: Sarjito Aris
Published: September 2024

This research investigates the multifaceted challenges of defense policy formulation by addressing three primary questions: How does political polarization affect defense policy? In what ways do cultural factors influence national defense policies? What are the primary bureaucratic obstacles in defense policy formulation, and how can they be mitigated? Utilizing Political Polarization Theory, the study examines how ideological divides hinder consensus-building and lead to policy stagnation. Constructivist Theory of International Relations explores how cultural narratives, historical legacies, and national identity shape defense strategies. The Bureaucratic Politics Model analyzes internal power struggles and inter-agency rivalries that complicate policy formulation. Qualitative research methods using secondary data, including literature reviews, policy documents, and case studies, are employed to examine these dynamics. Findings indicate that political polarization leads to delayed and compromised defense policies, cultural factors significantly influence strategic priorities, and bureaucratic obstacles impede efficient policy implementation. The study concludes with recommendations for mitigating these obstacles through strategic reforms, enhanced inter-agency coordination, and the adoption of new technologies. This research provides comprehensive insights for policymakers to navigate the complexities of defense policy formulation.
Local Culture-Based Leadership To Improve The Professionalism Of Employees At The Mentawai Islands Regency Personnel And Human Resource Development Agency
Authors: Imelda Sonya , Khairul Khairul , Pratomo Hurip
Published: September 2024

The research is motivated by the many emerging leadership model practices found today based on models from the United States, Europe, Japan, and China, giving the impression that Indonesian people do not have a model to organize or lead an organization. If studied in depth, existing local wisdom teaches a lot about leadership models. Local wisdom spread in various Indonesian communities, one of which is in the Mentawai Islands Regency contains various leadership models that can be used for organizational structuring, especially employee professionalism. This study aims to examine the perceptions of employees under the coordination of the Head of BKPSDM Mentawai Islands Regency using the theory of Local Culture-Based Leadership. Qualitative research uses a descriptive type of case study research because it wants to know and provide an overview of the circumstances studied. Data collection techniques are carried out by observation techniques, interviews, and documentation of informant determination based on consideration of knowledge and experience of the object of research. The results showed that the decision-making aspect involved all officials and staff. The formulation of problems is discussed together and not only the opinions of the leader but officials and staff in the environment contribute to the problems faced. In the aspect of conflict control, controlling conflicts is by the leader using power and authority and follow-up to resolve conflicts. In the aspect of building teamwork, the leader gives encouragement and input, and the leader has an important role in building the team.
Одеські трофейні експонати в колекції Національного музейного комплексу «Молдова» (Ясси)
Authors: Красножон Андрій
Published: September 2024

Шість пам’ятників епіграфіки Османської імперії вивезли співробітники Одеської трофейної служби у 1942 р. до міста Яси. З того часу їхня доля залишалася невідомою. Три з них належали до фортеці Ізмаїл і датовані 1795 р. Ще дві належали фортеці Аккерман і датувалися XVII-XVIII ст. Ще одна стела потрапила до Одеси зі Стамбула.
Першу групу пам’ятників було виявлено автором на початку 2014 р. Другу половину пам’ятників – у червні 2024 р. Усі пам’ятні плити досі залишаються в Румунії, у фондах Національного музейного комплексу «Молдова». Жодна з вивезених під час війни до Яс плит не була перевидана румунськими дослідниками протягом усіх повоєнних десятиліть, незважаючи на доступність цих матеріалів.
Історичний контекст появи кожної з цих пам’яток епіграфіки особливий. Ізмаїльські плити відображали час масштабної модернізації фортеці після того, як її було взято військами Суворова у грудні 1790 р. і знову повернуто Порті. Ці роботи очолив Рашид-ефенді, котрий згодом став турецьким комендантом Ізмаїла. Плита з Аккермана з написом Абу Бакра відображає період масштабного ремонту веж цитаделі фортечного комплексу після влучення в них блискавки у 1673 р. Плита з молитвою на честь Алі відбиває присутність у XVIII ст. громади суфіїв. Зрештою, стела з ім’ям Махмуд-бея носить епітафію на честь похованого у Стамбулі пірата. Всі ці пам’ятники епіграфіки Османа виявлені у фондах Національного музейного комплексу «Молдова» (м. Ясси). Їхньому введенню до наукового обігу і присвячена ця стаття.
Києво-Покровський жіночий монастир у соціокультурному просторі великого міста другої половини 19 – початку 20 ст.
Authors: Chuchalin Oleksandr
Published: September 2024

Метою статті є дослідження історії заснування, просторового розвитку, фінансово-господарської та благодійницької діяльності Києво-Покровського жіночого монастиря та з’ясування значення жіночих монастирів та їх чернецтва у соціокультурному просторі великого міста другої половини 19 – початку 20 ст.
Наукова новизна. Досліджено історію Києво-Покровського жіночого монастиря другої половин 19 – початку 20 ст., формування його архітектурно-господарського комплексу, соціального складу черниць, фінансово-господарської діяльності, місця у соціокультурному просторі Києва. До наукового обігу введено архівні матеріали, що відображають різні аспекти історії Києво-Покровського монастиря.
Висновки. Друга половина 19 ст. ознаменувалася зміною урядової політики щодо Російської православної церкви та її монастирів, що дозволило Київській єпархії відновити окремі обителі та заснувати нові монастирі. Києво-Покровський жіночий монастир, заснований у 1889 р., був останнім монастирем збудованим у місті Києві в синодальний період. Однак, за короткий час обитель змогла стати важливим духовним центром, сформувати духовний авторитет черниць та естетичний вплив урочистих монастирських богослужінь, вплинувши на культурну атмосферу великого міста.
Розташування обителі у центральній частині Києва стало вирішальним з точки зору її господарської та соціокультурної діяльності. Статус великого міста та мета його засновниці з організації такого монастиря впливали на формування складу черниць і послушниць, що відрізняло цей монастир від інших обителей єпархії. У першокласні монастирі, до яких належав і Києво-Покровський спільножительний жіночий монастир, частіше вступали представниці дворянського стану. На посаді настоятельниць цього монастиря були, як правило, представниці так званого «освіченого чернецтва».
Соціально-економічні та суспільно-політичні зміни, що припали на другу половину 19 – початок 20 ст. сприяли тому, що традиційно релігійна функція православних монастирів уже не задовольняла потреб поставлених часом. У зв’язку з цим особлива увага приділялася відкриттю при монастирях навчальних закладів, посиленню благодійницької та культурно-просвітницької діяльності. Процеси урбанізації та торгово-промислового розвитку Києва спонукали керівництво та чернецтво монастиря йти в ногу з часом, відповідати запитам оточуючого соціуму. Завдяки монастирям, Київ, в умовах стрімких трансформаційних змін суспільства, продовжував зберігати свій неповторний образ древньої християнської столиці. У той же час монастирі ставали частиною міського середовища, вміло використовуючи результати урбанізації та економічного розвитку, поєднували значення релігійних та історико-культурних центрів. Їх відвідування прочанами та мандрівниками набувало не лише характеру поклоніння святині, але мало і просвітницький характер.
The Agreements Concluded by the Bulgarian State With Foreign Navigation Companies in the International Navigation on the Danube And Black Sea in the late 19th – early 20th centuries
Authors: Mitea Ionel Constantin
Published: September 2024

The purpose of the research paper is to reveal important moments in the history of international navigation on the Danube and the Black Sea in the late 19th – the early 20th centuries. Considering the broad picture of navigation, we will analyze specific issues related to the steps taken by Bulgaria for the development of navigation activities in its ports aimed at appropriate legislative changes and the conclusion of agreements with foreign shipping companies.
The scientific novelty is given by the analysis of how the approaches of some young riparian states, which wanted to impose their sovereign will and economic interests in their own ports on the Danube and the Black Sea, influenced regional navigation. In this historical context and reference period, we analyse, in detail, the agreements concluded by Bulgaria with foreign shipping companies, French and German, at the early 20th century.
Conclusions. The late 19th – the early 20th centuries faced a particular surge in the presence of navigation companies on the Danube and in the Black Sea ports, marked by the diversification of navigation activities and the establishment of ‘freedom of navigation on the River’, as an expression of ‘European interest’. The Danube ports were still the subject of the great powers’ interest and the shipping companies that stimulated commercial activities on the Maritime Danube.
Bulgaria, a young riparian state to the River that also benefitted from access to the Black Sea, initiated legislative and commercial steps, aiming at economic benefits and international visibility. These initiatives of the Bulgarian authorities expressed the incipient intentions to create a national shipping company that could successfully compete with the already established companies on the Danube and the Black Sea. The purposes of the agreements concluded with the German and French companies were to increase exports through Bulgarian ports and also the efficiency of the activity of the Bulgarian Railways, a vital area of the economy directly related to navigation. The actions of the Bulgarian government contributed substantially to the dynamism of navigation activities on the Danube and the Black Sea.
Evaluation of the use of prenatal immune stimulation to alter postnatal immune function in weaned pigs
Authors: Burdick Sanchez Nicole C. , Mitchell Ty , Broadway Paul R. , Bowen Brooke M. , Davis Emily M. , Dobbins Thomas , Barker Samantha N. , Legako Jerrad F. , Petry Amy L. , Carroll Jeffery A.
Published: September 2024

This study was designed to determine whether exposure to low-dose endotoxin (lipopolysaccharide; LPS) during gestation can enhance immunity to a subsequent LPS challenge in piglets after weaning. Pregnant sows (parity: 2.6 ± 1.4) were assigned to prenatal immune stimulation (PIS; n = 7; administered 2.5 µg/kg BW LPS, i.m.) or saline treatment groups (CON; n = 7) administered at day 78 ± 1.8 of gestation. From the two prenatal treatment groups, barrows (n = 17 PIS, 17 CON) were identified at weaning (21 ± 1.3 day of age) to subsequently receive a post-weaning LPS challenge. On day −1, the pigs were fitted with indwelling jugular catheters and subcutaneous temperature loggers. On day 0, the pigs were challenged i.v. with LPS (10 µg/kg BW), and blood samples were collected at −2, 0, 1, 2, 4, 6, 8, 12, and 24 h relative to LPS challenge. There was a treatment × time interaction for subcutaneous temperature (P < 0.01), where the temperature increased more quickly at 1 and 2 h post-challenge in PIS compared to CON pigs. There was a tendency (P = 0.08) for less change in white blood cells, relative to baseline values, in PIS compared to CON pigs. There was a treatment × time interaction (P = 0.01) for lymphocyte concentrations where the concentrations were reduced in PIS compared to CON pigs at 8 h post-challenge. There was also a treatment × time interaction (P = 0.01) for the change in eosinophil concentrations, where there was less change in eosinophil concentrations from 1 to 12 h in PIS compared to CON pigs. There was a tendency (P ≤ 0.06) for a treatment × time interaction for serum interleukin-6 (IL-6) and IL-8. Granulocyte-macrophage colony-stimulating factor tended to be greater, and tumor necrosis factor-α tended to be reduced in PIS compared to CON pigs (P ≤ 0.08). These data suggest that exposure to endotoxin in utero may influence the postnatal innate immune response to endotoxin. More research is necessary to further understand the mechanism behind the differences observed and the potential long-term influence of prenatal immune stimulation on pig offspring.
The biomechanical evaluation of metacarpal fractures fixation methods during finger movements: a finite element study
Authors: Liu Mingrui , Luo Lincong , Lin Tao , Lv Xiaoyu , Vashisth Manoj Kumar , Li Jiaying , Shen Jianlin , Xu Lin , Huang Wenhua
Published: September 2024

Objective

This study used finite element analysis to simulate four commonly used fixation methods for metacarpal shaft oblique fractures during finger motion and evaluate their biomechanical performance. The aim was to provide evidence for clinically selecting the optimal fixation method, guiding early rehabilitation treatment, and reducing the risk of complications.

Methods

Finite element analysis simulated dynamic proximal phalanx motion (60° flexion, 20° extension, 20° adduction, and 20° abduction). We analysed stress, displacement, and distributions for dorsal plates, intramedullary nails, Kirschner wire, and screw fixation methods.

Results

At 60° of finger flexion and 20° of abduction, plate fixation demonstrated greater stability and minimal displacement, with a peak displacement of 0.19 mm; however, it showed higher stress levels in all motion states, increasing the risk of failure. The stability of the intramedullary nail was similar to that of the dorsal plate, with a maximum displacement difference of 0.04 mm, and it performed better than the dorsal plate during adduction of 20°. Kirschner wire showed the highest stress levels of 81.6 Mpa during finger flexion of 60°, indicating a greater risk of failure and unstable displacement. Screws had lower stress levels in all finger motion states, reducing the risk of failure, but had poorer stability. Stress and displacement distributions showed that the dorsal plate, intramedullary nail, and Kirschner wire mainly bore stress on the implants, concentrating near the fracture line and the proximal metacarpal. In contrast, the screws partially bore stress in the screw group. The anterior end of the metacarpal mainly hosted the maximum displacement.

Conclusion

This study demonstrates that under simulated finger motion states, the dorsal plate fixation method provides the best stability in most cases, especially during finger flexion and abduction. However, high stress levels also indicate a higher risk of failure. The intramedullary nail is similar to the dorsal plate in stability and performs better in certain motion states. Kirschner wire exhibits the highest risk of failure during flexion. Although screws have poorer stability in some motion states, they offer a lower risk of failure. These findings provide important reference and surgical selection strategies for treating metacarpal fractures.
A data-driven approach to enhance urban infrastructure for sustainable mobility and improved quality of life in highly populated cities. Case study: Barcelona
Authors: Sanchez-Sepulveda Monica V. , Navarro Joan , Amo-Filva Daniel , Fonseca David , Antúnez-Anea Felipe , Barranco-Albalat Albert
Published: September 2024

The concentration of populations in large cities has resulted in significant challenges affecting residents’ quality of life, particularly mobility and environmental pollution. Addressing these issues is crucial for enhancing environmental, social, and economic wellbeing. This study proposes leveraging Open Data repositories to identify critical points in urban infrastructure for promoting accessible, sustainable, and healthy mobility. We hypothesize that by analyzing and optimizing urban infrastructure based on available data, it is possible to mitigate the negative impacts of urbanization on mobility and environmental quality. A data-driven tool, incorporating data visualization, exploratory analyses, and classification and clustering algorithms, was employed to develop a system that not only presents data intuitively but also offers insights and recommendations for improvement. The findings, based on a case study in Barcelona, are transferable to other cities worldwide, offering valuable insights for urban planning professionals in future city improvement projects. While the city of Barcelona serves as a case study, the methodology is transferable to other cities worldwide.
Evaluation of spatial interpolation techniques for urban heat island monitoring in small and medium sized cities
Authors: Brabant C. , Dubreuil V. , Dufour S.
Published: September 2024

The growth of a city is typically accompanied by densification and sprawl, the former through verticalization, urban renewal, and the filling in of empty spaces. All of these activities extend and intensify the urban heat island (UHI), which is quantified in this study as the difference in daily minimum temperature between urban and rural areas. Here, we investigate this phenomenon in the area of Rennes (France) and 17 surrounding cities using the Rennes Urban Network which comprises 93 weather stations. This study aims to 1) determine the optimal method for spatializing UHI in Rennes, France, 2) estimate and spatialize the UHI in the small peri-urban cities surrounding Rennes. For this, we model mean UHI and intense UHI using three methods of interpolation—multi-linear regression (MLR), ordinary kriging (OK), and regression kriging (RK)—based on data from 2022. We find that the RK method is the most suitable overall, with an RMSE of 0.11°C for mean UHI and 0.25°C for intense UHI. This approach allows stochasticity to be taken into account, and thus provides a better representation of UHI variation within Rennes and its peri-urban cities.
Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases
Authors: Li Hui , Chen Lixia , Liu Meikuai , Bao Meng , Zhang Quanbo , Xu Shihao
Published: September 2024

Background

Sentinel lymph node metastasis (SLNM) is a critical factor in the prognosis and treatment planning for breast cancer (BC), as it indicates the potential spread of cancer to other parts of the body. The accurate prediction and diagnosis of SLNM are essential for improving clinical outcomes and guiding treatment decisions.

Objective

This study aimed to construct a Lasso regression model by integrating multimodal ultrasound (US) techniques, including US, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS), to improve the predictive accuracy of sentinel lymph node metastasis in breast cancer and provide more precise guidance for clinical treatment.

Results

A total of 253 eligible samples were screened, of which 148 were group benign and 105 were group malignant. There were statistically significant differences (p < 0.05) between group malignant patients in terms of age, palpable mass, body mass index, distance to nipple, maximum diameter, blood flow, microcalcification, 2D border, 2D morphology, and 2D uniformity and group benign. The Lasso regression model was useful in the diagnosis of benign and malignant nodules with an AUC of 0.966 and in diagnosing SLNM with an AUC of 0.832.

Conclusion

In this study, we successfully constructed and validated a Lasso regression model based on the multimodal ultrasound technique for predicting whether SLNM occurs in BCs, showing high diagnostic accuracy.
Assessing the invasive potential of Saguinus midas in the extent of occurrence of the critically endangered Saguinus bicolor
Authors: Lagroteria Diogo , Cavalcante Thiago , Zuquim Gabriela , Röhe Fábio , Medeiros Aline S. M. , Hrbek Tomas , Gordo Marcelo
Published: September 2024

Saguinus bicolor is one of the most endangered primates in the Amazon, mainly due to threats related to human activities, such as deforestation and habitat fragmentation. Moreover, the encroachment of Saguinus midas, a widely distributed species, into the restricted range of S. bicolor, poses further conservation challenges and extinction risks. This study focuses on the potential niche overlap and competition between these two species, which are closely related callitrichid primates with a parapatric distribution. We employed the support vector machine (SVM) algorithm to investigate the potential of invasion by S. midas into the area of occurrence of S. bicolor by quantifying and comparing the habitat suitability for both species. We used environmental variables that are known to be relevant descriptors of callitrichid niches and a similarity test was applied to assess niche overlap between the two species. Our analysis reveals that the majority of the area occupied by S. bicolor exhibits higher habitat suitability for S. midas than for S. bicolor. Furthermore, we found a high niche similarity between the species. These results suggest a significant invasive potential of S. midas into the range of S. bicolor. The research highlights the concerning prospects for the long-term persistence of S. bicolor, emphasizing the urgent need for conservation measures. The conservation and maintenance of an ecologically functional urban forest matrix, along with the preservation of habitat quality and connectivity in rural areas, are crucial. Monitoring the current contact areas between the two species and the areas indicated as highly and moderately suitable for S.midas in the range of S. bicolor is also essential, and the observed trends in the occupation of these areas need to be incorporated into adaptive conservation strategies to protect less anthropogenically impacted areas. The findings are expected to contribute to the ongoing National Action Plan for the conservation of S. bicolor and support the management and conservation efforts for the species.
Association between fatty liver index and cardiometabolic multimorbidity: evidence from the cross-sectional national health and nutrition examination survey
Authors: Gu Xinsheng , Gao Di , Zhou Xinjian , Ding Yueyou , Shi Wenrui , Park Jieun , Wu Shaohui , He Yue
Published: September 2024

Background

Metabolic dysfunction associated steatotic liver disease (MASLD) contributes to the cardiometabolic diseases through multiple mechanisms. Fatty liver index (FLI) has been formulated as a non-invasive, convenient, and cost-effective approach to estimate the degree of MASLD. The current study aims to evaluate the correlation between FLI and the prevalent cardiometabolic multimorbidity (CMM), and to assess the usefulness of FLI to improve the detection of the prevalent CMM in the general population.

Methods

26,269 subjects were enrolled from the National Health and Nutrition Examination Survey 1999–2018. FLI was formulated based on triglycerides, body mass index, γ -glutamyltransferase, and waist circumference. CMM was defined as a history of 2 or more of diabetes mellitus, stroke, myocardial infarction.

Results

The prevalence of CMM was 10.84%. With adjustment of demographic, anthropometric, laboratory, and medical history covariates, each standard deviation of FLI leaded to a 58.8% risk increase for the prevalent CMM. The fourth quartile of FLI had a 2.424 times risk for the prevalent CMM than the first quartile, and a trend towards higher risk was observed. Smooth curve fitting showed that the risk for prevalent CMM increased proportionally along with the elevation of FLI. Subgroup analysis demonstrated that the correlation was robust in several conventional subpopulations. Receiver-operating characteristic curve analysis revealed an incremental value of FLI for detecting prevalent CMM when adding it to conventional cardiometabolic risk factors (Area under the curve: 0.920 vs. 0.983, P < 0.001). Results from reclassification analysis confirmed the improvement from FLI.

Conclusion

Our study demonstrated a positive, linear, and robust correlation between FLI and the prevalent CMM, and our findings implicate the potential usefulness of FLI to improve the detection of prevalent CMM in the general population.
Design and validation of a scale of motivation for scientific publication in Peruvian university professors (MoSCPU-UP)
Authors: Carranza Esteban Renzo Felipe , Mamani-Benito Oscar , Huancahuire-Vega Salomón , Casildo-Bedón Nancy , Cabrera-Orosco Isabel , Turpo-Chaparro Josué Edison
Published: September 2024

The study’s objective was to design and validate a motivation scale for scientific publication in Peruvian university professors (MoSCPU-UP). Instrumental research where a scale of 13 items distributed in 2 factors (Intentional State and Commitment-will) was designed and validated. The sample comprised 546 university professors (62.1% male) aged 22 to 67 (M = 45.05 and DS = 9.32). The sample was separated into two subgroups for the exploratory and confirmatory factor analysis. For analyzing the validity of evidence based on the content, the Aiken V coefficient was used; for construct validity, exploratory and confirmatory factor analysis was used. Reliability was studied through Cronbach’s alpha coefficient. The results show that the items received a favorable evaluation (Aiken’s V > 0.70). Goodness of fit indices were adequate (IFC = 0.93, TLI = 0.92, and RMSEA = 0.08). Likewise, the correlation between factors 1 and 2 was significant (p < 0.05). Evidence of validity based on the relationship with other variables with measures of professional self-efficacy is significant and acceptable reliability (α = 0.91; 95% CI = 0.89–0.92). In conclusion, the MoSCPU-UP scale is an instrument that reports evidence of validity and reliability.
Students' perception of the strengths and weaknesses of the inclusive educational model of Brazilian municipal public schools
Authors: Capellini Vera , Muñoz-Martínez Yolanda , Gómez Puerta Jose Marcos , Reis Verônica Lima dos , Rocha Eduardo Pimentel da
Published: September 2024

Introduction

Brazil is a signatory of important documents that advocate the promotion and access to equitable, inclusive, and quality education. However, the construction of inclusive policies, practices, and cultures has been little discussed in the country, making the process of educational inclusion of children with specific educational needs difficult.

Method

In this study, we used the Index for Inclusion to investigate children's perceptions considering the three things they like most about their school and the three things they dislike. Data was analyzed qualitatively through content analysis, using prefixed categories created according to the children's answers to the Index (strengths and weaknesses), categorized considering the dimensions and subdimensions assessed by the Index.

Results

The results revealed that children perceive the infrastructural and urban barriers present in their context, which are considered weaknesses for developing inclusive policies, practices, and cultures in their school contexts. On the other hand, they do not show attitudinal barriers, that is, they do not judge others for their differences.

Discussion

Working on differences, from the first school stage, to build a positive relationship between children and the development of practices and an inclusive school can benefit the construction of a school community free of segregating values present in our culture, contributing to the development of inclusive policies, practices, and cultures in school environments.
Simulation of low-load operation for a 350 MW supercritical unit
Authors: Xu Shiming , Yu Bo , Zhou Qiang , Zhang Xiangyu , Wang Fujun , Zhou Huaichun
Published: September 2024

Currently, there is a scarcity of studies exploring the safe operating parameters for coal-fired power units at loads below 30%.To accurately understand the operating characteristics of coal-fired units under low load conditions, and to provide a design basis for flexibility modifications, a simulation model coupled with boiler and turbine was established, which includes the flue gas and air system, steam and water system, steam turbine, and steam extraction heat recovery system, and the iterative calculation strategy for low load conditions was proposed. The simulation calculation was performed on a 350 MW supercritical coal-fired unit, with the model results showing a high degree of alignment with the unit’s design and operational parameters. Under the condition of 269MW, the maximum calculation error between the model’s predicted exit flue gas temperature of the air preheater and the actual operational results was 8.84%. This discrepancy was due to a sudden increase in the operating flue gas temperature, which may be associated with a blockage in the air preheater. And the simulation results under low load conditions indicate that when the unit load is below 20%, the furnace total airflow is controlled to no less than 30% of the airflow at Maximum Continuous Rating (BMCR) and the minimum feedwater flow rate can be reduced to 20% of that in Turbine Heat Acceptance (THA) load, and the unit switches to wet state operation around 20% load. As the unit load decreases, the coal consumption rate for power generation and steam turbine heat consumption rate both increase significantly. The coal consumption rate for power generation at 30% load is increased by 13.3% compared to BMCR load, and it is increased by 32.5% at 15% load which is operated in wet state. Under low load conditions, the coal consumption rate of the unit can be reduced by decreasing the oxygen content in the flue gas, reducing the minimum feedwater flow rate, and implementing boiler water recirculation.
Optimal planning strategy for charging and discharging an electric vehicle connected to the grid through wireless recharger
Authors: Boukhchana Asma , Flah Aymen , Alkuhayli Abdulaziz , Ullah Rahmat , El-Bayeh Claude Ziad
Published: September 2024

The increasing number of electric Vehicles (EVs) and their influence on the power grid present difficulties that this article addresses by suggesting optimal planning methods for EV charging and discharging. EV charging and discharging operations are effectively managed by creating both locally and globally optimal planning schemes. Future transportation could be changed by the widespread adoption of dynamic wireless power transfer systems in conjunction with EVs, as they would enable speedier travel and continuous EV battery recharging. Dynamic wireless power transfer is a practical answer to problems with electric vehicles. The electrification of automobiles will have a significant influence on the power infrastructure due to the increase in demand for electricity. In this study, we provide an optimal planning method worldwide and a locally optimal strategy for EV charging and discharging. To minimize the total cost of all EVs that charge and discharge during the day, we propose an optimization problem for global planning in which the charging powers are optimized. The simulation results demonstrate that the proposed planning schemes can effectively reduce the total electricity cost for EV owners while also minimizing the impact on the power grid. The globally optimal planning scheme achieves the lowest electricity cost, while the locally optimal scheme provides a good balance between cost reduction and computational complexity.
Effect of cellulose-lignin ratio on the adsorption of U(Ⅵ) by hydrothermal charcoals prepared from Dendrocalamus farinosus
Authors: Yang FanQin , Li Hanhan , Wang Boya , Fan Wei , Gu Xiaoyan , Cao Ying , Hu Shanglian
Published: September 2024

Herein, the impact of varying proportions of cellulose/lignin in bamboo on the production of hydrothermal biochar was investigated. Different characterization techniques were applied to explore the structure of hydrothermal biochar derived from three different genotypes (215, 30-A, 52-B) of Dendrocalamus farinosus, and the adsorption behavior of uranium by these hydrothermal biochars was evaluated. It was found that a decrease in cellulose/lignin ratio (3.08, 2.68, and 2.58) positively influenced the specific surface area and pore volume of hydrothermal biochar. Consequently, the prepared hydrothermal biochars exhibited adsorption capacities for U(VI) ions at levels of 14.78 mg/g, 24.68 mg/g, and 26.02 mg/g respectively under these three ratios. The adsorption process by 52-B-220 well complied with the Freundlich isotherm, which indicated that the multi-layer adsorption occurred on the solid liquid interface, but single-layer adsorption was evident in those prepared from genotypes 30-A and 215. This study demonstrated that adjusting biomass feedstock composition as an effective strategy for enhance the quality of biochar.