bluuebunny/crossref_metadata_2025 huggingface dataset:
Resort Otellerde Çevrim İçi Yorum Manipülasyonu
Authors: SOP Serhat Adem , ATASOY Fuat , GÜNAYDIN Yusuf
Published: September 2023

Resort otel yöneticilerinin çevrim içi yorum manipülasyonuna yönelik tutum ve davranışlarını belirlemek amacıyla yürütülen bu araştırmada, otellerde çevrim içi yorumları manipüle edici uygulamaların neden ve nasıl yapıldığı ortaya koyulmaktadır. Bu amaç doğrultusunda nicel araştırma yaklaşımı ve betimsel araştırma tasarımı benimsenmiş, Bodrum’da faaliyet gösteren 42 otel işletmesinin yöneticilerine anket uygulanmıştır. Frekans analizi yoluyla ulaşılan sonuçlar otel yöneticilerinin; işletmenin itibarını korumak, rakiplere üstünlük sağlamak, tur operatörlerinin baskısını yönetebilmek ve tazminat ödemeleriyle karşılaşmamak için çevrim içi yorum manipülasyonu yapabildiklerini göstermektedir. Bu kapsamda uygulanan stratejiler ise olumsuz yorumları engellemek için misafirlere çeşitli parasal teşviklerin (ücretsiz geç çıkış vb.) sunulması, personelden bir misafir gibi sahte yorum yazmasının veya misafirlere olumlu yorum yazdırmasının istenmesi, rakip otellerin aleyhine sahte yorumların yazılması ve çevrim içi platformlara yüksek komisyon bedellerinin ödenmesidir. Araştırmanın sonuçları mevcut literatürle ilişkilendirilerek tartışılmış ve otelcilik sektöründeki güncel durum üzerine bir değerlendirme yapılmıştır. Çevrim içi yorum manipülasyonu konusunu resort oteller perspektifinden inceleyen öncü çalışmalardan olması, bu araştırmanın özgünlüğünü ve literatüre katkısını ortaya koymaktadır.
PENGETAHUAN DAN DUKUNGAN SUAMI TENTANG PEMBERIAN ASI EKSKLUSIF DI KELURAHAN CAMBAYA KOTA MAKASSAR
Authors: Afriani Afriani , Wirawati Amin  , Fitriati Sabur  , Hariyanti Hariyanti
Published: September 2023

Relationship between Knowledge and Support of Husband with the Exclusive Giving of Breast milk in Cambaya Village, Makassar City, (guided by Hj. Hidayati and Afriani) Exclusive breast milk is breast Milk which is given to babies as the main food that can be well received by the baby's digestive system and given exclusively for 6 months. Knowledge of the importance of exclusive breastfeeding is needed by mothers and families because breast milk is the first and main intake for the babys health at this time. In addition to the support of husband and family also has its own factors in influencing the psychological condition of the mother which will have an impact on the success of breastfeeding. More over support of husband and family also has own factors in influencing the psychological condition of mother who will have an impact to the success of breastfeeding. This study aims to determine the relationship between husband's knowledge and support with exclusive breastfeeding, with analytical survey methods and with a cross sectional approach. Subjects of this study were 78 mothers who had infants aged 6-12 months whose was determined by using the Sanley Lemeshow formula and include to the criteria. The research design uses purposive sampling technique. The statistical analysis used in this study was the chi-square statistic, with a confidence level of α = 0.05. The results of the research obtained from sufficient maternal knowledge can motivate exclusive breastfeeding in the cambaya village, husband's support which is sufficient can motivate the mother to give exclusive breastfeeding in the cambaya village. So that it can be concluded that there is a relationship between knowledge and support of husbands with exclusive breastfeeding in Cambaya Makassar. Therefore, it is expected that there is a need to increase the role of health workers in providing information and information about the importance of exclusive breastfeeding. Beside that, husband and family support is also needed to provide support and encouragement so that mothers can breastfeed well.
Intervenções assistidas por animais e a importância do médico veterinário neste contexto: revisão de literatura
Authors: De Carvalho Jardim Gabriela , Reis Gomes Mariana , Timm Krolow Mariana , Ramos de Freitas Vitória , Pereira Dias Tábata , Brum Cleff Marlete
Published: September 2023

Os benefícios oriundos da convivência humano-animal impulsionaram o interesse e conhecimento acerca das práticas das Intervenções Assistidas por Animais (IAA). Entretanto, não há um consenso definido acerca da obrigatoriedade do médico veterinário. Dessa forma, o objetivo desta revisão foi demonstrar a importância do médico veterinário nas equipes de IAA. Para tal, realizou-se uma busca manual de artigos científicos publicados entre os anos de 2002 e 2022, nas bases de dados PubMed, Scielo e Google Acadêmico, usando termos específicos como indexadores. Ao final, 57 artigos foram selecionados. Para que as IAA’s ocorram é necessário o treinamento e acompanhamento de saúde dos animais, porém muitas destas atividades têm sido desenvolvidas por outros profissionais. As IAA são comumente desenvolvidas em pacientes imunossuprimidos, o que sugere uma importante preocupação, pois os animais podem atuar como reservatórios ou disseminadores de patógenos. Assim afirmamos a importância do médico veterinário nas atividades de IAA, para prevenir que os indivíduos envolvidos, tanto homem quanto animal, sofram qualquer dano em relação à sua saúde física e mental.
Impactos do acolhimento institucional no desenvolvimento na adolescência pela perspectiva da Terapia do Esquema
Authors: Santos Gabriela de Araújo Braz dos , Peixoto Ana Cláudia de
Published: September 2023

Este artigo objetiva discutir os Esquemas Iniciais Desadaptativos desenvolvidos em adolescentes acolhidos institucionalmente e seus impactos no desenvolvimento. Dezenove participantes em situação de acolhimento institucional em um munícipio da Baixada Fluminense, no Estado do Rio de Janeiro, participaram da pesquisa. Os resultados revelaram: presença significativa dos esquemas de Abandono, Vulnerabilidade ao dano/doença e Desconfiança/Abuso. Problemas emocionais/comportamentais como depressão, ansiedade, agressividade e problemas sociais também se mostraram prevalentes, a partir da aplicação do Inventário de autorrelato Youth Self-Report (YSR) aplicado nos adolescentes; 57% da amostra apresentou nível clínico para comportamentos externalizantes demonstrando que os adolescentes investigados utilizavam estratégias disfuncionais para lidar com a ativação de seus esquemas. Portanto, a partir dos dados alcançados com essa pesquisa, considera-se urgente investir no contexto de relação e de desenvolvimento dos adolescentes, bem como, no contexto das políticas públicas dirigidas à infância e adolescência.
Evaluation of bergenin in amylase enzyme inhibition and lipid uptake in liver cells
Authors: V Diana Mendes do Nascimento , Barbosa Fabiano Sousa , Oliveira Micael Davi Lima , Oliveira Kelson Mota Teixeira , Almeida Patrícia Danielle Oliveira , Lima Emersom
Published: September 2023

Changes in the global economy contribute to a sedentary lifestyle and higher caloric intake, increasing the incidence of metabolic diseases. It is estimated that the number of individuals diagnosed with metabolic diseases will increase by 25% by 2030 and 51% by 2045. Natural products have been tested in metabolic diseases with positive results, as shown by bergenin. Thus, this work aimed to evaluate the possible effects of bergenin in models of metabolic disease through in silico and in vitro experimental procedures. Bergenin showed the ability to inhibit protein glycation by 19.88 ± 4.22% in the oxidative pathway and 8.32 ± 1.85% in the non-oxidative pathway. This study showed for the first time that bergenin has the potential to inhibit the α-amylase enzyme (33.89 ± 0.96%) using in silico and in vitro assays. Bergenin was not able to significantly inhibit lipid uptake by the Oil Red method. After these results, it is understood that bergenin has the potential to be better studied as a therapeutic option in metabolic diseases. However, additional in vivo studies are needed to better elucidate the possible pharmacological effects of bergenin in metabolic diseases.
Woman cartography in the Brazilian labor market: verses and reverses
Authors: Costa Murilo Marques , Pereira Alessandra dos Santos , Lúcio Drielly Neres , Adão Jorge Manoel , Pires Roseli Vieira
Published: September 2023

This article discusses the scenario that illustrates the role of women in the economy and society; addresses the issue that although this scenario has undergone significant changes in recent decades, female participation in the labor market in Brazil is still lower when compared to male participation. Thus, the general objective of the study is to analyze the working conditions of women. As for the methodological procedures, it is a bibliographical research, carried out in the following databases: Google Scholar, SciELO and repositories and it has a qualitative, descriptive and analytical approach. The results indicate that, in the Brazilian labor market, there are still differences between women and men, mainly with regard to remuneration and working hours, introducing an unexpected progress in female entrepreneurship.
Healh as a rignht: acesso f the street population to healts services
Authors: Santos Samuel Lopes dos , ALVES Aniclécio Mendes , Alves Ferreira Pedro Lucas , Paz Silva Filho Paulo Sérgio da , Sena Queiroz Bruna Furtado , Lopes Barbosa Marcela Flavia , Sabrina Rodrigues Jessica , Carvalho Alves Winícius de
Published: September 2023

This study aimed to: Describe, through a literary survey, the perception of homeless people in relation to the provision of health services and the accessibility process in the search for health care. Thus, the methodological design was chosen: an integrative review, conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Anslyses (PRISMA) protocol. We used as inclusion criteria primary studies that addressed the access to health services offered by public health institutions to homeless people, published from 2011 to November 2021 in any language. Databases: Medical Literature Analysis and Retrieval System Online (MEDLINE), via PubMed; Latin American and Caribbean Literature on Health Sciences (LILACS), via the Virtual Health Library (VHL) and the Spanish Bibliographic Index on Health Sciences (IBECS), also through the VHL. A total of 08 studies were obtained as results. It can be concluded that: there is a fragmentation in the accessibility process of homeless people to enter health services, such individuals permeate social stigmas, prejudice, inhumane situations and even the devaluation of their health problems. Inferring when their perception is that they are unattended by public policies and without direct health promotion and prevention actions.
Public policies and the professional training of young people in rural areas: An integrative review
Authors: Stampini Andreza , Carvalho Angelita Alves de , Reis Lílian Perdigão Caixêta , Nascimento-Souza Mary Anne
Published: September 2023

In recent years, researchers have studied the category of rural youth, that is, young citizens who have chosen to live in rural areas. The objective of the study was to identify, through an integrative literature review, public policies for access to education and professionalization of rural youth in the Brazilian context. The hypothesis is that public policies aimed at the rural environment allow rural youth access to teaching and learning and qualify them for the job market. As a methodological strategy, an integrative review research was used. Data collection was carried out in April and May 2022. In all, there were 14 works analyzed in this study. In addition, works with a time interval of 13 years, from 2009 to 2022, were considered. It is concluded that the objective of the article was achieved, since, through the analysis of the documents, it was possible to identify the public policies, as well as the programs of access to education and professionalization of rural youth in the Brazilian context, such as PRONAETC, PRONAF, EFA and CEFET.
Post-consumer PET/HDPE blends as an alternative route for marketing recycled materials
Authors: Teixeira Viviana Aparecida Pessôa Maia , Moraes Luanda Silva de
Published: September 2023

Polymers such as high-density polyethylene (HDPE) and polyethylene terephthalate (PET) are widely used by the packaging sector and widely consumed by society, generating large amounts of post-consumer waste, bringing reflection on the use of these materials (Macedo,2020). Aiming to reduce the impact of excessive disposal of these polymers in nature, proposals for the development of new materials, whose composition allows their reuse, have become imperative, as conscious innovations both in raw materials and in production Technologies (DAS, 2021). The objective of this work was to produce post-consumer PET/HDPE polymeric blends as a raw material option, replacing only post-consumer HDPE. For the development of this work, post-consumer PET/HDPE polymeric blends were prepared in different proportions, which were processed by extrusion and injection. The results of the thermal and mechanical properties showed that the presence of PET in the blends, in different concentrations, had an impact on the increase of the indices obtained in the thermal and mechanical analysis, when compared to the post-consumer HDPE matrix.
Social, biological factors and spatial distribution of patients with Diabetes Mellitus using insulin in a Brazilian population
Authors: Botelho Nahara , Madaalena Isabela , De Oliveira Daniela , Scaini Fabrício , Kuchler Patrick Calvano , Alves Diego Escobar , Thedei Júnior Geraldo , Gonçalves Jussara Maria , Kuchler Erika Calvano , Baratto-Filho Flares
Published: September 2023

The aim was to identify the social and biological factors involved in the control and follow-up of patients with Diabetes Mellitus using insulin. Sociodemographic data and data related to the control of Diabetes Mellitus were collected. The geographic information system (GIS) was used for georeferencing analysis. Statistical analysis was performed and p values <0.05 indicated a statistical difference. A total of 308 patients were included, 191 (62%) female and 117 (38%) male. The mean age was 59.8 years (standard deviation=12.5). Of the individuals who had an off-target HbA1c test, 60 (75%) had a test result in less than 12 months, 129 (86%) between 12 and 24 months, and 20 (87%) more than 24 months. The relationship between HbA1c results and social and biological factors showed no statistically significant difference (p>0.05). In the spatial analysis, it was observed that consultations over 12 months and off-target results were more distant from the health units. Conclusion: Gender, education, spatial distribution, overweight and obesity are factors involved in the control of Diabetes Mellitus in a Brazilian population.
The therapeutic itinerary of severe COVID-19 survivors in a small-town municipality
Authors: Eidt Vanusa Daiane , Alves das Mercês Nen Nalú
Published: September 2023

This study aimed to understand the trajectory undertaken by survivors of severe COVID-19 in a municipality in the interior of Brazil. It is a qualitative study with a descriptive and exploratory approach. Ten survivors of severe COVID-19 residing in a municipality with 17,000 inhabitants participated. Among the sought-after care were home, professional, and religious care. The categorization of narratives into "popular sphere and the praxis of self-care" and "professional sphere and the quest for resolution" highlights the influence of culture on the health-disease process and the care experience. The study demonstrated that the trajectory began with popular care, followed by professional and folk care, clearly indicating the interconnection of both practices in seeking health-related care. The importance of understanding the specificities in the care experience of severe COVID-19 reinforces the importance of including popular and religious practices in the healthcare system.
impact of implementing the health transformation strategy on health services delivery from employee’s point of view
Authors: Al-Shehri Hassan , Aloyuni Saleh Abdullah
Published: September 2023

The study aimed to assess the impact of the health transformation strategy on the provision of healthcare services from the perspective of employees in the Kingdom. The descriptive and analytical methodology was used, along with a questionnaire, to collect data from administrative staff in hospitals and healthcare centers. After analyzing the data, the study found that there is a high level of health transformation in the Kingdom across its three dimensions, and there is also a high level of healthcare service provision. The study also found a statistically significant positive correlation between the level of health transformation across its three dimensions and the level of healthcare service provision in the Kingdom. Important findings from the study include the need to improve the level of healthcare staff and provide a supportive and stimulating environment for their work, as well as improving communication with beneficiaries of healthcare services. The study recommended maintaining the Kingdom's excellent level of healthcare services by providing all the necessary resources and requirements to achieve the goals of Vision 2030.
Takaful Industry in the Era of Technological Advancement
Authors: Ahmad Zaki , Mokal Mahvish Nawaz , Rahman Mahfujur
Published: September 2023

The aim of this paper is to investigate how the takaful industry can address the issue of technological advancement. Furthermore, to explore the way by which takaful operators can compete with fintech insurers as well as in which areas takaful operators should focus on to innovate, e.g., technology or products, Additionally, to find out if there are any shariah concerns if takaful operators jump on the bandwagon of these fintech insurers, The findings of the research show that the impact of technological innovations extends beyond the takaful value chain itself to the whole takaful eco-system. The combination of big data and advanced analytics is reshaping the takaful industry, from underwriting to claims and marketing, by inventing new products and distribution channels. The threat from big-tech companies such as Google, Facebook, Apple, and Amazon have broadened the scope of the operator’s problem because these big-tech companies are currently offering insurance products through their websites. The Takaful industry should tie up with big tech companies to sell their products through their websites. Since these companies have deep knowledge and experience in technology, they have also gained a decent reputation as they have proven records of providing excellent services to their customers and have a vast global reach. This research brings insights for policymakers, regulators, and practitioners. The main insights in this paper are technological advancements in the takaful industry. It further answers the question of which areas Takaful operators should focus on to innovate, e.g., technology or products.
Enhancing Mutual Assistance: An Analysis of Sharia Insurance Fund Separation in Comparison to Conventional Insurance
Authors: Rizqa Agitsna Alya
Published: September 2023

Separation of funds in sharia insurance adheres to the main principle of mutual assistance (ta'awun), which means that each participant must have the intention to help each other. The application of the concept of separation of sharia insurance funds emphasizes the position of tabarru funds which may only be used for the needs of policyholders (ta'awun), while funds originating from the shareholder component (ujrah) can be used for the needs of insurance companies. This study aims to determine the concept of Islamic insurance in the separation of funds which is an advantage compared to conventional insurance. A qualitative method was chosen in this research, which used sharia insurance companies in Indonesia as the research object. Research findings state that the separation of sharia insurance funds is divided into tabaru (mutual assistance) funds and ujrah funds which is in accordance with the concept of fund theory. Efforts to invest higher levels have been made by the company, but the low investment returns mean that the profit sharing between participants and the company is lower, while investment losses will still be borne by the participants. Besides that, low claims on sharia insurance mean that companies do not need to use their reserve funds to cover the high level of tabarru fund claims.
Potential of Culinary Tourism I-Bumi Cafe and Resto In Supporting Tourism In West Sumatra
Authors: Mandalia Siska , Wulandari Wiranda , Fadila Nessa
Published: September 2023

Culinary tourism is one of the superiorities in the tourism industry that has enormous potential to be developed and utilized if managed properly and professionally. Culinary tourism complements other forms, such as cultural, nature, and marine tourism, which are already popular among West Sumatra tourists. This research aims to identify the potential of culinary tourism in I-Bumi Cafe & Resto in supporting tourism in West Sumatra. This research uses a qualitative approach using the literature study method of several writings in journals, articles, and documents related to analyzing culinary tourism potential. The results of this study indicate that the existence of I-Bumi Cafe & Resto has the potential to support tourism in West Sumatra through culinary tourism. The possibility possessed by I-Bumi Cafe & Restaurant supports tourism activities in West Sumatra. The strengths possessed by I-Bumi Cafe & Restaurant must be maintained and paid attention to as well as possible, weaknesses must be eliminated, opportunities that exist are immediately exploited, and threats or challenges must be anticipated presently. In this way, steps can be taken for improvement in the future.
Review of COVID-19 Impact and Islamic Social Finance
Authors: Haidar Abdullah , Annisa Satifa Siti
Published: September 2023

The goal of this study is to identify the trajectory of published research in the cited journals on the topic of Islamic social finance during the COVID-19   pandemic. The study was carried out in September 2020. There were 47 research publications analyzed. A journal that was released in 2020 is the focus of the study. The VOSviewer application program is used to examine and evaluate the acquired data to discover the challenges with Islamic social finance and bibliometric mapping of COVID-19   research progress. The study's findings demonstrate a considerable increase in the number of publications on this subject. Four groupings are identified on the bibliometric visualization's map of the development of COVID-19   research. There are 19 patients in Cluster 1, 13, in Cluster 2, 9, in Cluster 3, and 8 in Cluster 4.   The findings of this study suggest that, in to lessen the effects of the existing economic crisis, there should be a particular focus on the growth of Islamic social finance.
Hybrid Alpha Power Marshall Olkin G Class of Distributions
Authors:   Department of Mathematical Statistics, Faculty of Science, University of Aleppo, Aleppo, Syria, Taher Fatimah ,   Department of Mathematical Statistics, Faculty of Science, University of Aleppo, Aleppo, Syria.,   Department of Mathematical Statistics, Faculty of Science, University of Aleppo, Aleppo, Syria., Zeina Mohamed Bisher , Ranneh Moustafa Mazhar
Published: September 2023

This research presents a new class of probability distributions derived as a hybrid class between alpha power transformation class and Marshall Olkin G class and we call it the hybrid alpha power Marshall Olkin G class of distributions (HAPMOG). Characteristics properties of this new class were derived including moments, moments generating function, characteristic function, reliability and hazard functions, and its probability density function was presented in linear combination. Also, many generated distributions depending on this new class was presented and well-studied including HAPMOG-Exponential, HAPMOG-Weibull, HAPMOG-Freshet. This new class of distributions helps in modelling new forms of data, which has important applications in engineering, communication systems, networks modeling, etc.
Implementasi Brain Based Learning Dalam Mengasah Multiple Intelligences Di MTs Al-Qur’an La Raiba Hanifida Jombang
Authors: Utami Risyunida , Idawati Khoirotul
Published: September 2023

Basically, every child is intelligent and has a tendency toward nine intelligences. To sharpen these intelligences, we need a learning model that optimizes brain activity. Brain-based learning is a learning model that involves the entire brain's potential as an approach to sharpening students multiple intelligences. The purpose of this research is to describe the concept of brain-based learning in the MTs al-Qur’an La Raiba Hanifida, the implementation of brain-based learning in multiple intelligences in the MTs, and the supportive and inhibitory factors of brain-based learning in multiple intelligences in the MTS and MA al-Qur'an La Raiba. In this study, the researchers used qualitative research and a case study approach. Data is collected using three techniques: (1) observation, (2) interviews, and (3) documentation. Data analysis techniques use domain analysis and taxonomic analysis. Data validation techniques use several things, including extending participation and triangulation. The result of this research is that: (1) The concept of brain-based learning in the MTs al-Qur’an La raiba is a learning model used as an approach in the learning process using the entire brain potential to maximize success. (2) Implementation of brain-based learning in sharpening multiple intelligences in the Hanifida MTs: planning, implementation, and evaluation 4) Factors supporting the implementation of brain-based learning in MTs and MA: training, support from the foundation, integration with the cottage, teachers (facilitators, providing support and guidance), availability of learning resources, and the ability of the student. The hindering factors are the difficulty in obtaining a valid reference for the age of MTs and MA students, taking a long time to upgrade the video, the recording device not meeting the desired specifications, internet problems, and changing the paradigm of teachers and students
Կարգավորվող երկրորդ տիպի դիաբետիկ պացիենտների մոտ մասնակի շարժական պրոթեզներով կոգնիտիվ ֆունկցիաների և ուղեղի ակտիվության բարելավումը
Authors: Սաղաթելյան Լ. Ռ. , Վարդանյան Ա. Ռ. , Երանյան Մ. Հ.
Published: September 2023

Цель настоящего исследования – оценка влияния восстановления утра-ченных задних окклюзионных контактов с помощью частичных съемных протезов на активность головного мозга и когнитивные функции у пациентов с контролируемым диабетом 2-го типа. Накапливающиеся данные свидетельствуют о том,что потеря зубов может быть основным фактором риска для головного мозга и когнитивных нарушений. Было отобрано 20 пациентов с контролируемым диабетом 2-го типа (45-55 лет) с частичной адентией (Кеннеди 1,2 класс). Все пациенты ранее не носили протезы. Частичные съемные протезы были изготовлены из термопластичной акриловой смолы. Активность головного мозга и когнитивные функции оценивались с помощью электроэнцефалограммы и опросника Mini- Mental State Examination до и через 1 месяц после протезирования. Оценка ЭЭГ показала увеличение среднего значения через 1 месяц но-шения протеза, мини-тест когнитивных показателей свидетельствует об увеличении общего значения через 1 месяц. Восстановление утраченного заднего окклюзионного контакта у пациентов с контролируемым диабетом 2-го типа с удовлетворительными показателями частичных съемных протезов может способствовать улучшению функции мозга и когнитивного статуса.
Accumulating evidence suggests that tooth loss may be a major risk factor for brain and cognitive impairment. This study aims to evaluate the effect of removable partial dentures on brain activity and cognitive function in patients with controlled type 2 diabetes. The study included 20 patients with controlled type 2 diabetes mellitus aged 45-55 years with partial adentia. Patients had unilateral or bilateral peripheral edentulism in both the maxilla and mandible and had not previously worn removable partial dentures. Thermoplastic acrylic resins were used to make removable partial dentures. Brain activity and cognitive functions were assessed using EEG and MMSE before prosthetics and 1 month after prosthetics. The study of cognitive functions and EEG indicates an improvement in brain activity and cognitive functions after 1 month of wearing the RPD. Rehabilitation of unilateral or bilateral peripheral adentia with RPD improves brain function and cognitive status in patients with controlled type 2 diabetes.
Динамика выявляемости остеопороза у мужчин за последние 10 лет, по данным рентгеновской денситометрии
Authors: Асланян Н. В.
Published: September 2023

Օստեոպորոզը մեծահասակների շրջանում աշխարհում ամենատարածված հիվանդություններից է: Օստեոպորոզը հանդիպում է ամեն 3-րդ կնոջ և ամեն 4-րդ տղամարդու մոտ 50 տարեկան և ավելի բարձր տարիքային խմբերում: Խնդիրը հիմնականում համարվում է կանացի, քանի որ ավելի հաճախ ախտորոշվում է կանանց մոտ, սակայն տղամարդկանց շրջանում ազդրի՝ օստեոպորոզով պայմանավորված կոտրվածքների հետևանքները զգալիորեն ավելի ծանր են լինում, իսկ մահացությունը 2 անգամ ավելի բարձր է, քան կանանց մոտ: Հայաստանում տղամարդկանց շրջանում երբևէ չեն անցկացվել պոպուլյացիոն հետազոտություններ՝ օստեոպորոզի տարածվածությունը հայտնաբերելու և ոսկրերի միներալային խտության նվազման աստիճանը որոշելու համար: Ուսումնասիրության նպատակն է գնահատել օստեոպորոզի հայտնաբերման դինամիկան տղամարդկանց մոտ վերջին տարիների ընթացքում՝ համաձայն DXA-ի տվյալների, և FRAX – ով բացահայտել ռիսկի այն գործոնները, որոնք առավելապես նպաստում են կոտրվածքների առաջացմանը տղամարդկանց մոտ (մինչև 50 տարեկան և 50-ից բարձր տարիքային խմբերում): Հետազոտությունները կատարվել են HOLOGIC ֆիրմայի ռենտգենյան դենսիտոմետրով 3 ժամանակային կետերում' 2013 թ., 2018 թ. և 2022 թ., և գնահատվել է օստեոպորոզի ախտորոշման դինամիկան Հայաստանում: Ստացված տվյալներն ապացուցում են, որ օստեոպորոզը մնում է թերագնահատված խնդիր տղամարդկանց մոտ ինչպես ամբողջ աշխարհում, այնպես էլ Հայաստանում, չնայած որ առկա է հիվանդների թվի զգալի ավելացում համեմատած նախորդ տարիների հետ: Osteoporosis is nowadays one of the most common diseases among the elderly. Every third woman and every fourth man at the age of 50 and above suffer from osteoporosis. Most of the people affected by osteoporosis are women. Although the problem of osteoporosis is considered to be more female, complications after a hip fracture of men are more severe than those of women. Mortality rate of men after a hip fracture is twice higher than that of women. In Armenia, no population studies have been conducted to detect male osteoporosis. The purpose of the study is to assess the dynamics of the detection of male osteoporosis over the past 10 years according to DXA, and to identify a factor in FRAX that most affects the risk of fractures of men at various age. The study was conducted on an X-ray densitometer by HOLOGIC at three time points: in 2013, 2018 and 2022. We evaluated the dynamics of detection of male osteoporosis in Armenia. The findings confirm that osteoporosis remains an underappreciated problem for men, both worldwide and in Armenia. Although, according to our data, there is a considerable tendency in the increase of the number of appeals among men over the past 10 years.
Սննդամթերքի ոլորտը կանոնակարգող նորմատիվային փաստաթղթերում առկա տարբերությունները Staphylococcus ցեղի մանրէների վերաբերյալ
Authors: Նիկոլյան Ս. Հ. , Ցականյան Ա. Վ. , Անդրեասյան Ն. Ա. , Մարտիրոսյան Ս. Թ.
Published: September 2023

Основной причиной пищевых отравлений могут быть стафилококковые бактерии, различающиеся по способности ферментировать сахара и продуци-ровать коагулазу, подразделяясь на коагулазоположительные и коагулазоотри-цательные. Наряду с опасными представителями данного рода и широко рас-пространенными S.aureus, другие коагулазоположительные стафилококки, такие как некоторые штаммы S.intermedius и S.hyicus, также имеют факторы вирулентности и могут вызывать заболевания пищевого происхождения. Более того, изучение и выявление различий между евразийскими (ЕАЭС), международными и национальными (Республика Армения) нормативными документами по безопасности пищевых продуктов на предмет стандартизации коагулазоположительных стафилококков позволят совершенствовать микро-биологические требования в Армении и влиять на темпы развития науки.
The major cause of food poisoning can be staphylococcal bacteria, which differ in their ability to ferment sugars and produce coagulase subdivided into coagulase-positive and coagulase-negative. Along with dangerous members of this genus and the widespread S.aureus, other coagulase-positive staphylococci, such as some strains of S.intermedius and S.hyicus, also have virulence factors and can cause foodborne diseases. Moreover, the study and identification of differences between the Eurasian (EAEU), international, and national (Republic of Armenia) food safety regulations for the standardization of coagulase-positive staphylococci will improve microbiological requirements in Armenia and influence the pace of science development.
Hybrid Revascularisation in Cases of Longer Arterial Occlusive Diseases of Lower Limbs in Combination with Diabetis Mellitus
Authors: Hambardzumyan K. M.
Published: September 2023

Целью нашего исследования была оценка результатов баллонной дилатации поверхностных, подколенных и передних отделов артерий ниже колена без
стентирования. В это исследование было включено 30 пациентов с заболеванием
периферических сосудов (ЗПС). Все пациенты были мужчинами с диабетом 2-го
типа. Во всех случаях выполняли дуплексное сканирование и компьютерную
томографию. Клиническая фаза заболевания периферических артерий оценивалась по WIFI III. Все операции включали чрескожную транслюминальную
ангиопластику (реканализацию и баллонную дилатацию) поверхностной бедренной артерии (ПБА), подколенной артерии (ПА) и передних отделов большеберцовых артерий в сочетании с профундопластикой в 27 (90%) случаях и полного
протезирования короткой ПБА в 3 (10%). ИБС наблюдалась в 6 (20%) случаях.
Среди них коронарное стентирование было представлено у всех. Сразу после
процедуры отмечалось улучшение кровотока в стопе и/или купирование болевого
синдрома. Сочетание периферической баллонной дилатации с профундопластикой или коротким аллопротезированием ПБА у пациентов со средней стадией
WIFI дало достаточные достоверные результаты для спасения конечности.
Մեր հետազոտության նպատակն էր գնահատել ծնկից ներքև գտնվող
մակերեսային, պոպլիտեալ և առաջային զարկերակների օդապարիկային
լայնացումն առանց ստենտավորման: Այս ուսումնասիրությունը ներառում էր
ծայրամասային անոթային հիվանդությամբ 30 հիվանդ: Բոլոր հիվանդները
տղամարդիկ էին և ունեին 2-րդ տիպի շաքարախտ: Բոլոր դեպքերում կատարվել են դուպլեքս սկանավորում և համակարգչային տոմոգրաֆիա։
Ծայրամասային զարկերակային հիվանդության կլինիկական փուլը գնահատվել է WIFI III-ի միջոցով: Բոլոր վիրահատությունները ներառում էին
մակերեսային ազդրային զարկերակի (ՄԱԶ), ենթածնկային և տաբիալ
զարկերակների ներմաշկային տրանսլյումինալ անգիոպլաստիկա (վերականալիզացիա և բալոն անգիոպլաստիկա) 27 (90%) դեպքերում և կարճ ՄԱԶ-ի
ամբողջական փոխարինում 3 դեպքերում (10%): Սրտի իշեմիկ հիվանդություն
առկա էր 6 (20%) դեպքերում: Բոլոր այդ դեպքերում կատարվել էր կորոնար
զարկերակների ստենտավորում։ Միջամտությունից անմիջապես հետո
նկատվել է ոտքի արյան հոսքի բարելավում և/կամ ցավի թեթևացում: WIFI-ի
միջին փուլով հիվանդների մոտ ծայրամասային բալոն անգիոպլաստիկայի
համակցումը պրոֆունդոպլաստիկայի կամ ՄԱԶ-ի կարճ ալոպրոթեզավորման հետ ցուցադրել է բավարար հուսալի արդյունքներ վերջույթը փրկելու
համատեքստում:
Վիզուալիզացիոն մեթոդների կիրառումը ժամանակակից ճառագայթային ուռուցքաբանությունում
Authors: Անտոնյան Պ. Մ.
Published: September 2023

В связи с широким внедрением в клиническую практику современных методов лучевой терапии, позволяющих увеличить точность доставки поглощенных доз, оптимизация планирования облучения становится особенно актуальной. В обзоре рассмотрена роль современных методов визуализации на всех этапах проведения лучевой терапии онкологических заболеваний – симуляции, планирования, мониторинга облучения и оценке эффективности лечения. Показана перспективность применения морфологических и функциональных методик МРТ, ПЭТ/КТ с метаболическими и рецепторными маркерами, УЗИ, позволяющих повысить точность планирования и обеспечить эффективный мониторинг лечебного процесса.
In connection with the widespread introduction of new methods of the radiation therapy into the clinical practice, which makes it possible to increase the accuracy of delivery of the absorbed doses, the optimization of radiotherapy planning becomes especially relevant. The review describes the role of modern methods of visualization in all stages of radiation therapy for oncological diseases – simulation, planning, dose delivery monitoring and evaluation of treatment effectiveness. The prospects of using morphological and functional methods of MRI, PET/CT with metabolic and receptor markers and ultrasonography, which can upgrade precision of the radiation therapy planning and improve the monitoring of therapeutic processes, are shown.
Effect of Using Ethanol Extract of Artocarpus Heterophyllus Leaves and Olea Europea Fruit Oil Combination on Facial Skin
Authors: Widyawati Tri , Daulay Milahayati
Published: September 2023

Background: Artocarpus heterophyllus (A. heterophyllus) leaves and Olea europea (OE) fruit oil are natural sources that have been traditionally used for health and skin care purpose. Objective: To assess the potential synergistic effect of combining ethanol extract of A. heterophyllus leaves (AHLE) and OE fruit oil in the formulation of clay masks, specifically in terms of their effect on facial skin. Methods: AHLE was obtained by the maceration method, while OE was purchased commercially. Total phenol and flavonoid content were calculated and a DPPH assay was conducted to evaluate the antioxidant properties. Furthermore, the four formulas prepared were F1 (AHLE 5%), F2 (OE 10%), F3 (AHLE 5% + OE 10%), and F4 (AHLE 2.5% + OE 5%). Adult women received weekly facial treatments with the formulated mask for one month. The effect of these treatments was evaluated based on several skin parameters, including moisture, oiliness, texture, collagen levels, pigmentation, sensitivity, and the presence of wrinkles. Furthermore, the data obtained were analyzed using the Wilcoxon sign-ranked test. Results: AHLE contained total phenolic, flavonoid, and antioxidant activity higher than OE. Clay masks in all formulations showed homogeneity and do not contain coarse grain. After four weeks of treatment, the efficacy of the formulations demonstrated a significant effect. F1 exhibited a reduction in wrinkles by 36.27%, while F3 improved oily skin by 21.39%, enhanced skin texture by 44.32%, reduced pigmentation by 30.30%, and decreased skin sensitivity by 49.18%. Furthermore, F4 demonstrated an increase in skin moisture levels by 27.89% and a boost in collagen production by 32.00%. Conclusion: The combination of AHLE and OE at 5% and 10% demonstrated superior effectiveness compared to their individual use.
Factors Affecting the Outcomes of COVID-19 in Diabetes Patients at Haji Adam Malik General Hospital Medan, Indonesia
Authors: Marpaung Nadya , Lubis Mustafa , Amelia Rina
Published: September 2023

Background: COVID-19 is a virulent viral infection by SARS-CoV-2 which caused pandemic and high mortality. One of the numerous risk factors for worse clinical outcomes in COVID-19 patients is the presence of comorbidity. Diabetes Mellitus is a chronic metabolic disease frequently in COVID-19 patients. Insulin resistance, causes chronic inflammation in the body, may aggravate the clinical outcome COVID-19 patients. Objective: The aim of the study was to examine factors that impact clinical outcomes in COVID-19 T2DM patients. Methods: The method used an analytical method with cross sectional design. Population is inpatients in Haji Adam Malik Hospital diagnosed with COVID-19 and Diabetes Mellitus Type 2 with 99 inpatients as sample. The data used are secondary data obtained through medical records from a hospital covering patients characteristics and laboratory result The data was analyzed using t-independent and chi square test with SPSS program. Results: Clinical outcomes for 99 patients are 60 patients are cured and 39 patients are dead. analytical study found a significant correlation between factors impacting clinical outcomes on COVID-19 patients with T2DM that are HbA1c level, D-dimer, cholesterol total and COVID-19 degree of severity and the clinical outcomes (p<0,05). Conclusion: HbA1c level, D-dimer, total cholesterol and the infection degree of severity affects the clinical outcomes on COVID-19 with T2DM (p<0,05).
Combined Cataract and Corneal Transplantation Surgery Without Viscosurgical Devices
Authors: Kuzman Tomislav , Bakrac Ana , Meter Ana , Gabric Ivana , Gacina Dina , Pauk Sania , Jukic Andjela , Skegro Ivan , Masnec Sanja , Kalauz Miro
Published: September 2023

Background: The most common complications after performing the triple Descemet’s stripping automated endothelial keratoplasty (DSAEK), which combines the cataract phacoemulsification, intraocular lens implantation and DSAEK procedure, are detachment or decentration of the donor lamella and postoperative interface haze. One reason for this is the retained viscoelastic used during surgery. Objective: This study aimed to describe triple DSAEK procedure without the usage of viscoelastic and to discuss its potential benefits on surgical outcomes. Methods: The surgical procedures and outcomes of patients with Fuchs’ dystrophy and lens opacification who underwent the triple DSAEK were retrospectively reviewed. The surgical procedure was described, and postoperative complications were studied. Results: The study included 10 eyes of 10 patients. Capsulorhexis and IOL implantation performed in locally potentiated anesthesia compared to general anesthesia did not significantly differ (P > 0,05). The mean preoperative best-corrected visual acuity was 0.75 LogMar. The mean postoperative best-corrected visual acuity was 0.2 LogMar. The central graft thickness before surgery was 129.6 μm and 6 months after surgery was 114.2 μm. Successful attachment of the donor lamellae was observed in all 10 patients. None of the patients had postoperative interface haze or any other possible viscoelastic caused complication. Conclusion: Although viscoelastic can facilitate certain aspects of the triple DSAEK procedure, we conclude that this procedure can be performed completely without its use. If performed by a trained surgeon, the procedure can be feasible without the complications of donor lamella detachment, decentration, or interface haze.
Serum Periostin Levels in Acute Myocardial Infarction Patients: a 3-month Follow-up Study
Authors: Tin Nguyen , Minh Huynh , Thang Doan , Phuong Phan
Published: September 2023

Background: Heart attack, acute myocardial infarction, are a major cause of morbidity and mortality in Western countries and are rapidly pandemic in developing and underdeveloped countries. Periostin concentration increases in the blood of patients after acute myocardial infarction and affects the process of cardiac remodeling leading to myocardial fibrosis. Objective: To evaluate the correlation between serum periostin levels and cardiac function and acute myocardial infarction patients’ short-term prognosis (three months after onset).Methods: Fifty-two acute myocardial infarction patients were prospectively enrolled in the present study, and 52 controls were established. The levels of periostin of acute myocardial infarction patients at 5-7 days after the onset were measured using enzyme-linked immunosorbent assay. Other blood tests and echocardiography were performed during the patient’s hospital stay. The correlation between periostin and TIMI, GRACE scores, body mass index, laboratory findings, and 3-month post- acute myocardial infarction data, including pro-B-type natriuretic peptide and echocardiographic parameters, were investigated. Results: Serum periostin levels increased significantly in acute myocardial infarction patients compared with normal controls. There was an association between serum periostin at diagnosis and cardiac function three months after acute myocardial infarction: serum periostin was in negative correlation with ejection fraction (r = - 0.31, p = 0.028); positive association was found between serum periostin level and left ventricular end-diastolic diameter (r = 0.38, p = 0.006). Conclusion: Serum periostin levels increase in acute myocardial infarction, and serum periostin can be used to predict cardiac function three months after acute myocardial infarction.
Association Between Left Ventricular Strains and Cardiovascular Risk Factors in Type 2 Diabetic Patients: a Controlled Cross-sectional Study
Authors: Trang Nguyen , Vu Nguyen , Chi Le
Published: September 2023

Background: Cardiovascular complications are the leading cause of death in diabetic patients. Speckle tracking echocardiography can early detect left ventricular systolic dysfunction even when normal ejection fraction. Objective: The study aims to evaluate left ventricular systolic function by Speckle tracking echocardiography and its relation with cardiovascular risk factors in type 2 diabetic patients. Methods: A controlled cross-sectional descriptive study was conducted on 150 patients (75 type 2 diabetic patients and 75 controls). Results: Type 2 diabetic patients had global longitudinal strain (-17.02±3.06%), global circumferential strain (-29.04±6.39%) were lower than the control group (p<0.05). Global longitudinal strain was correlated with systolic blood pressure (r=0.3), diastolic blood pressure (r=0.2), fasting plasma glucose (r=0.5), HbA1c (r=0.2), total cholesterol (r=-0.25), (p<0.05). Global circumferential strain was correlated with systolic blood pressure (r=0.2), diastolic blood pressure (r=0.2), HDL (r=-0.3), (p<0.05). Conclusion: Type 2 diabetic patients have reduced global longitudinal strain and global circumferential strain. The reduction of global longitudinal strain, global circumferential strain was correlated with cardiovascular risk factors (hypertension, not good glycemia control, increasing BMI, dyslipidemia).