bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN PROBLEM BASED LEARNING PADA MATERI PENCEMARAN LINGKUNGAN UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK KELAS X MIA 3 SMA NEGERI 3 SURAKARTA
Authors: Astuti Hesti Retno Puji , Prayitno Baskoro Adi , Suwarno Suwarno
Published: March 2021

The purpose of this research is to improve student’s critical thinking skill on Environmental Pollution Subject at class X MIA 3 of SMA Negeri 3 Surakarta. The research is a Classroom Action Research with 2 cycles of action. Each cycle consist of 4 phases which is planning, acting, observing, and reflecting. The result of the observations showed, 1) interpretation skill 43.97%, 2) analysis 29.31%, 3) evaluation 32.76%, 4) inference 43.10%, 5) explanation 53.45%, and 6) self-regulation 52.59%. Average of students’ critical thinking skill procentage is 42,53%. The method of data collection is through observation, tests, and documentation. Technical analysis of data is technical qualitative descriptive. Data validation is use triangulation methods. The results of the application of Problem Based Learning on Environmental Pollution Subject showed an increase of students’ critical thinking skill. Students’ critical thinking skill in the first cycle is 70,83%. Students’ critical thinking skill in the second cycle is 75%. Based on the result of the research, we can conclude that the application of Problem Based Learning on Environmental Pollution Subject in general can improve students’ critical thinking skill at class X MIA 3 of SMA Negeri 3 Surakarta, despite the increase that occurs varies in each cycle.

 

Keywords : Critical Thinking Skill, Problem Based Learning
Pengembangan Model Pembelajaran Group Investigation Media Vido Story Pokok Bahasan Keseimbangan Lingkungan Untuk Meningkatkan Berpikir Kritis Siswa
Authors: Awaliya Sofiyati , Pujiastutik Hernik
Published: March 2021

Tuban Regency is one of the areas that holds the potential of nature, this can be seen from the number of large factories established in Tuban Regency. The existence of this large factory causes changes in the surrounding environmental balance. Based on the results of observation of learning in SMA Muhammadiyah 03 Bancar class X on the subject of environmental balance is still conventional with the lecture method and discussion of this matter leads to less interesting and boring learning therefore there needs to be a development of learning models where students can engage in a social solution Namely the Group Investigation learning model (GI). The purpose of this research is to develop a model of learning by using the environment as a learning medium that is packaged in the form of video story to cultivate students' critical thinking skills. The students' critical thinking ability can be measured from aspects of identifying problems, interpreting, giving relevant ideas and drawing conclusions. This type of research is a research development, which is the development of a learning model that is very appropriate for the material of environmental balance class X semester even, the resulting draft then validated by two experts and one teacher as a user. The results showed the average validation of two experts and one user is 83.529% which indicates valid criteria and is worthy of use. From the results of small-scale test results amounted to 15 students who analyzed with the normalized gain obtained N gain> 0.7. These results indicate that there is a significant improvement in critical thinking of the students so that it can be concluded that the development of this learning model is very valid and feasible to be applied to improve critical thinking of the students.
Penerapan Penelitian Tindakan Kelas Cooperative Learning Tipe Peer Teaching untuk Meningkatkan Keterlibatan Siswa Dalam Pembelajaran Biologi
Authors: Dewi Nory Shenta , Ramli Murni , Rinanto Yudi
Published: March 2021

The research aims to increase students' engagement in Biology learning by applying cooperative learning method specifically peer teaching. The subjects consisted of 32 high school students focusing on Low Achievement (LA) and High Achievement (HA) students. This research is classroom action research (CAR) with 3 Cycles. The research procedure includes the stage of reflection, planning, implementation of action and observation. Behavioral Engagement (BE) data obtained through observation, other data in the form of Psychological Engagement (PE) and Cognitive Engagement (CE) obtained through student engagement questionnaire based on Student Engagement Instrument (SEI). Technique of data validation used is triangulation technique. Technique of analysis data performed by data reduction, data presentation and drawing conclusions based on qualitative descriptive analysis. The results showed that cooperative learning method specifically peer teaching can increase student engagement in biology learning. The average percentage of all BE aspects observed in LA students before the treatment given, Cycle I, Cycle II and Cycle III respectively was 13.72%; 35.24%; 48.26% and 64.24% respectively. Meanwhile BE results of HA students before the treatment given, Cycle I, Cycle II and Cycle III respectively were 22.22%; 48.97%; 56.6% and 64.76% respectively. The results of PE of LA students before the treatment given to Cycle III increased by 3.54% while PE in HA students before the treatment given to Cycle III increased from 3.75%. The result of CE analysis of LA students has increased before the treatment given toward Cycle III that is 2.94% while in HA students increased by 2.95%.
Teknik Instruksional Pertanyaan Guru Di Tahap Evaluating Data, Driving A Conclusion, Presenting The Project In Class As Preffered & Discussion Project Based Learning Untuk Meningkatkan Skor Valid Relationship Concept Map
Authors: Rahayu Yacinta Arum Dwi , Rinanto Yudi , Widoretno Sri
Published: March 2021

This research aimed to calculate the valid relationship score of concept map (CM) using instructional technique of teacher’s questions in the stages of evaluating data, driving a conclusion, presenting the project in class as preferred & discussion project-based learning. This research was a classroom action research. This research was a classroom action research with the research subject of 36 students in X MIPA of Senior High School. The research procedure was including: planning, lesson plan completed with assessment, acting, observing and reflecting.  Validity test in this research was using triangulation method that consisted of verification of valid relationship CM score, documentation based on expert CM and interview to present the valuable relation between concepts. Reduction done to choose the data completion, data interpretation and conclusion based on the complete valid relationship data. Data analysis was using descriptive qualitative. The result of this research shows that valid relationship score of expert CM in pre-research, cycle I and cycle II were written as follows. 1.95%-14.98% with 13.89% of the under averaged students’ score and 11.11% of the over averaged students’ score. 3.08%-61.54% with 19.44% of the under averaged students’ score and 11.11% of the over averaged students’ score. 16.58%-32.16% with 11.11% of the under averaged students’ score and 16.67% of over averaged students’ score. Thus, the use of instructional technique of questioning in the stages of evaluating data, driving a conclusion, presenting the project in class as preferred & discussion project-based learning improving the valid relationship CM score on the individual and classical.

 
Pengaruh Media Pembelajaran Natural Picture Terhadap Hasil Belajar Siswa Pada Mata Pelajaran IPA
Authors: Rudianto Ruril , Nurtjahyani Supiana Dian
Published: March 2021

Science is a science that learns about life in the world from all aspects. To be able to study these subjects requires a deeper understanding of the material. Application of learning innovations needs to be done to achieve the objectives of science subjects especially by teachers so as to provide hands-on experience for students to acquire innovative learning. Based on the observations at SMP Negeri 1 Bancar known that the results obtained by students less satisfactory. The process of teaching and learning is done by lecture method, when the learning process takes place many students are sleepy and chatting. To improve the learning outcomes in science subjects especially biology required the existence of learning innovation, namely by using Natural Picture learning media. The purpose of this study is to determine whether there is an influence of Natural Picture learning media on student learning outcomes in science biology subjects in SMP Negeri 1 bancar. The type of research used is Quasi Eksperimen. This research was conducted at SMP Negeri 1 Bancar with research sample that is student of class VII A which amounted to 32 students as experiment class and student of class VII E which amounted to 32 students as control class. The research design used was Pre-Test research design - Post-Test Control Group Design. Based on the results of data analysis of learning results, the average value in the experimental class given treatment using Natural Picture learning media is higher than the control class using the lecture method. The experiment class is 87.12 and the control class is 74.37. In the hypothesis test the Sig value. (2-tailed) of 0.000, when compared with α 0.05 then Sig <α then H0 is rejected and H1 accepted. Thus, it can be concluded that there is a difference in mean values of experimental class learning outcomes and control classes. That is, there is the effect of learning media Natural Picture on student learning outcomes.

 
Kajian pemalsuan bekatul dan tepung ikan di Wilayah Jawa Tengah
Authors: Utama Cahya Setya , Sulistiyanto Bambang
Published: March 2021

Objective: The research aimed examine the quality adulteration of bran and fish meal in the Central Java region.

Methods: The materials used are rice bran and fish meal originating from 17 regions in Central Java which include Rembang, Jepara, Batang, Solo, Boyolali, Pekalongan, Kendal, Temanggung, Magelang, Ungaran, Pati, Purwodadi, Demak, Salatiga, Kudus, Klaten and Semarang. The research method uses descriptive method. Sampling was carried out by purposive random sample to represent the area of the area used as the research site (10 shops in 1 region with different districts and / or villages). Measurement of the parameters of adulteration on bran used Phloroglucinol test, buoyancy test and specific gravity test, while fish meal used urea test.

Results: The results showed that the bran which was tested for Phloroglucinol and positive buoyancy was faked by adding husks, and was found in the Pati and Demak areas. Density test describes rice bran with non-standard density in Purwodadi, Kendal, Temanggung, Demak and Semarang. Fish meal adulteration occurred in the Boyolali and Pati regions with positive urea content.

Conclusions: The conclusion of this research is that good quality of rice bran based on phloroglucinol test, husk floating test and bulk density test were found in Rembang, Jepara, Solo, Boyolali, Magelang, Ungaran, Salatiga and Kudus areas, the quality of fish meal indicated for adulteration based on the urea test was Pekalongan and Purwodadi areas.
Congratulations! Best Paper Award 2011
Authors: Office Editorial
Published: March 2021

The second Best Paper Award ceremony was held in Kasumigaseki, Tokyo, Japan, on July 29, attended by the winner and IJAT committee members who took part in the selection process for IJAT, Vol.4 (2010). The award winner(s) will also be announced on the IJAT website and given a certificate and a nearly US$1,000 honorarium.

The Best Paper Award 2011 is as follows:

Title: Adaptive Cutting Force Prediction in Milling Processes

Authors: Takashi Matsumura, Takahiro Shirakashi, and Eiji Usui

IJAT, Vol.4, No.3, pp. 221-228, 2010
Congratulations! Best Paper Award & Best Review Award 2013
Authors: Office Editorial
Published: March 2021

The fourth Best Paper Award 2013 and the first Best Review Award 2013 ceremony was held in Kasumigaseki, Tokyo, Japan, on August 2, 2013, attended by the winner and IJAT committee members who took part in the selection process. The Best Paper was severely selected from among 81 papers published in Vol.6 (2012) and the Best Review was selected from 9 reviews published from 2010 to 2012. The Best Paper Award winner was given a certificate with a nearly US$1,000 honorarium and the Best Review Award winner was given a certificate with commemorative shield.

 

The Best Paper Award 2013 is as follows:

Title: Estimation of Dynamic Mechanical Error for Evaluation of Machine Tool Structures

Authors: Daisuke Kono, Sascha Weikert, Atsushi Matsubara, and Kazuo Yamazaki

Int. J. of Automation Technology Vol.6 No.2, pp. 147-153, March 2012

 

The Best Review Award 2013 is as follows:

Title: Indirect Measurement of Volumetric Accuracy for Three-Axis and Five-Axis Machine Tools: A Review

Authors: Soichi Ibaraki and Wolfgang Knapp

Int. J. of Automation Technology Vol.6 No.2, pp. 110-124, March 2012
Intelligent Edutab Box: Supporting Real-Time Face-to-Face Collaborative Learning
Authors: Omae Yuto , Mizukoshi Kazutaka , Furuya Tatsuro , Oshima Takayuki , Sakakibara Norihisa , Mizuochi Yoshiaki , Yatsushiro Kazuhiro , Matsushita Masaya , Takahashi Hirotaka ,   Department of Industrial Engineering and Management, College of Industrial Technology, Nihon University 1-2-1 Izumi, Narashino, Chiba 275-8575, Japan,   Digital Alliance Co., Ltd. 2-12-1 Kitaguchi, Kofu, Yamanashi 400-0024, Japan,   Elementary School Attached to the University of Yamanashi 1-4-1 Kitashin, Kofu, Yamanashi 400-0005, Japan,   Joetsu University of Education 1 Yamayashiki-machi, Joetsu, Niigata 943-8512, Japan,   Yamanashi Prefectural University 5-11-1 Iida, Kofu, Yamanashi 400-0035, Japan,   Nagaoka University of Technology 1603-1 Kamitomioka, Nagaoka, Niigata 940-2188, Japan,   Research Center for Space Science, Advanced Research Laboratories, Tokyo City University 8-15-1 Todoroki, Setagaya, Tokyo 158-0082, Japan
Published: March 2021

Educational benefits of collaborative learning have been demonstrated in several studies and various systems have been developed to date. Numerous efforts have been made to enhance these benefits by supporting collaborative learning with information and communications technology. These efforts have primarily involved support for constructing collaborative learning groups, for collaborative learning in e-learning environments, and for collaborative learning analysis. This study aims to develop a computer-supported collaborative learning system that supports instructors in real time to facilitate collaborative learning in a face-to-face environment with multiple learners at the same time to provide enhanced support. Both the learner and instructor have one tablet terminal and conduct collaborative learning in a single classroom. Herein, the learner can use the tablet to save an educational log and freely browse the educational log of another learner. By referencing the educational logs, learners can learn through face-to-face communication. Additionally, the instructor can determine (1) who is viewing whose educational log and to what extent and (2) which learner is struggling to achieve targets. Herein, an overview of the proposed system is provided and the results obtained using the proposed system are reported to evaluate its effectiveness.
Derechos humanos, desaparición forzada y feminicidio en el Estado de Chihuahua
Authors: Medina Parra Rosa Isabel
Published: March 2021

La violencia contra las mujeres constituye una violación a los Derechos Humanos y uno de los problemas sociales más graves, es el mecanismo de control ejercido por el poder masculino, sobre el comportamiento, el cuerpo y los derechos de las mujeres, para evitar que transgredan el orden social y se mantengan subordinadas, cuyas máximas expresiones son la desaparición forzada y el feminicidio. La normatividad en México y el Estado de Chihuahua, presenta avances significativos en materia de derechos humanos, sin embargo dicho tipo de violencia se ha incrementado considerablemente en las últimas décadas, contabilizándose en centenas los casos registrados anualmente.
¿Experiencias de segregación o acoso en la maquiladora? Testimonios de trabajadores(as) en Ciudad Juárez, Chihuahua
Authors: Limas H Myrna , Frías Martínez Fernanda Nohemí
Published: March 2021

Una tarea clave que inició el Instituto Nacional de las Mujeres del gobierno mexicano en la década 2000 fue certificar empresas según el Modelo de Equidad de Género (MEG), ante el compromiso de cumplir con acuerdos internacionales en aras de propiciar ambientes laborales libres de violencia de género y promover la equidad e igualdad de oportunidades. El objetivo en este artículo es exponer algunas experiencias de empleados(as) de una empresa maquiladora certificada en tal modelo, enmarcando dos ejes: segregación laboral por razones de género y acoso/hostigamiento sexual. El trabajo en campo consistió en realizar entrevistas durante mayo y junio 2017. El análisis se enfoca en seis categorías: discriminación, puestos y salarios, relaciones personales, conocimiento y percepción del tema, eventos de acoso, y, atención y seguimiento a denuncias.
PREVALENCE OF HUMAN PARVOVIRUS B19 IgG AND IgM ANTIBODIES AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC AT FEDERAL TEACHING HOSPITAL IDO-EKITI, NIGERIA.
Authors: Akele Richard Yomi , Abelekum Jennifer Tamuno , Oluboyo Bernard Oluwapelum , Akinseye Janet Funmilayo , Enitan Seyi Samson , Olayanju Olusola Ayodeji , Akele Emmanuel Jide
Published: March 2021

Background: Human Parvovirus B19 (B19V) is a DNA virus, transmitted through respiratory secretions, hand-to-mouth-contact, blood transfusion and trans-placental transfer. It causes high mortality and morbidity in pregnant women, thus contributing to poor maternal and child health. B19V has been neglected due to dearth of epidemiological data. The aim of this study was to determine the sero-prevalence of Human Parvovirus B19 antibodies among pregnant women attending antenatal clinic at Federal Teaching Hospital Ido-Ekiti, Nigeria. Materials and Methods: This cross-sectional study enrolled pregnant women attending Federal Teaching Hospital Ido-Ekiti from January to May 2019 to obtain sero-epidemiological data. One hundred and twenty-two (122) consenting pregnant women were enrolled following institutional ethical approval. They were administered structured questionnaire and venous blood was collected in plain tubes for serum extraction. Sera samples were analyzed for IgG and IgM antibodies using the enzyme linked immunosorbent assay method. Percentages, median, chi-square and multivariate analysis were carried out using SPSS version 17. Results: The prevalence of IgG was 44.3% (54/122), IgM 41.8% (51/122), and IgG/IgM 28.7% (35/122) leaving 55.7% (68/122) of the population uninfected. The median age of participants was 22 (Interquartile range 18-25) years among which 36-45years had the highest prevalence which was not statistically significant (p=0.09 4.75). There was association between miscarriage, still birth, history of blood transfusion and prevalence of Human Parvovirus B19 (p<0.05). Conclusion: There is a high Prevalence of B19V among pregnant women attending antenatal clinic in this study. This underscores the need for testing and immunization of pregnant women against B19V.
A REVIEW ON EMERGING PATHOGENESIS OF COVID-19 AND POINTS OF CONCERN FOR RESEARCH COMMUNITIES IN NIGERIA
Authors: Muhammad Mubarak , Ibrahim Salisu Ahmed , Yarube Isyaku Umar , Bello Bashir
Published: March 2021

Background: COVID-19 remains an emerging pandemic that continuously poses an alarming threat and challenge to economic, social and well-being of the people throughout the world. It also remains an evolving disease which complete pathogenesis that translates into clinical features is only just emerging by each second of the day. There have been observations about the emerging trends of the disease in Nigeria like in any other country in the world where there is outbreak. This study examined from evidence-based literature the emerging pathogenesis of COVID-19 and important points of concern of the disease in Nigeria. Materials and Methods: The paper reviewed published articles in PubMed and Google Scholar using search terms ‘COVID-19” and “SARS-CoV-2”, as well as searched for general COVID-19 information on internet. Results: The result summarized literature on emerging pathogenesis of COVID-19 and important points of concern as well as research questions as to the peculiar trends of the disease in Nigeria. Conclusion: Pathogenesis of COVID-19 remains an emerging knowledge and there are many important research questions that need to be scientifically answered for a successful containment of COVID-19 in Nigeria. It is recommended that all members of intellectual research communities should join the fight against COVID-19 pandemic.
DEFECTS OF THE TREATMENT AND DIAGNOSTIC PROCESS IN IN-PATIENT PROFILE “PSYCHIATRY” CONDITIONS
Authors:   Central Research Institute for Organization and Informatization of Medical Care, Ministry of Health of Russia, Moscow, Russia, Davidov D.R. , Shikina I.B. ,   Central Research Institute for Organization and Informatization of Medical Care, Ministry of Health of Russia, Moscow, Russia
Published: March 2021

Significance. Timely identification of defects in the treatment and diagnostic process during internal quality audit of care delivery stimulates evidence-based organizational and management decisions and improves quality of care delivery to mental patients. Material and methods. A retrospective analysis of 270 records of internal quality audit of care to mental patients treated at the Mental Hospital # 4 of the Moscow Healthcare Department has been conducted. A total of 156 inpatient records (57.8%) from 2015 to 2018 were compared with 114 inpatient records (42.2%) in 2019. Results and discussion. Heads of the structural units and deputy heads of the health care facility have evaluated quality of care delivery at the two levels of control. Primary medical documentation was assessed on 12 items (from 0 to 1 point). The arithmetic mean of the assessments for each of the items was calculated - the overall quality factor. At both levels of control, defects in the care delivery were described. The quality factor at the 1st level of control equalled to 0.95 (0.92; 0.96), and 0.86 (0.79; 0.91) at the 2nd level. The quality factor at the 2nd level of control in 2015 - 2018 (1.0 (0.90; 1.00)) was statistically significantly higher than in 2019 (0.86 (0.79; 0.91)) (p = 0.011). Data for the complete 2019, despite the order of the Ministry of Health of the Russian Federation as of June 7, 2019 No. 381n, were observed and obtained in accordance with the requirements of the Moscow Healthcare Department Order No. 932 as of October 30, 2019 “On procedure for implementing internal quality audit and safety performance of health organizations of the state healthcare system of the city of Moscow”. Conclusion. The ongoing monitoring of quality of inpatient health care delivery to mental patients to identify defects in the treatment and diagnostic process using internal quality audit records helps to improve quality of care delivery to patients.
Herramientas de mercadeo tradicional y digital utilizadas por grandes empresas ubicadas en países en vías de desarrollo y su relación con el desempeño exportador: el caso de Costa Rica
Authors: Quirós-Gómez Josué , Arce-Gutiérrez Susan
Published: March 2021

Rev.esc.adm.neg

Las exportaciones juegan un papel clave en el desarrollo económico de los países. Estas se han visto beneficiadas por el uso de internet, según estudios previos. No obstante, la literatura no es clara con respecto a la relación que existe entre las herramientas de mercadeo digital y tradicional con el desempeño exportador de grandes empresas ubicadas en países en vías de desarrollo. Con el fin de determinar si existe esta relación y, además, identificar cuáles herramientas poseen un mayor impacto en este tipo de organizaciones, se desarrolla la presente investigación. Se basa en una metodología cualitativa por medio de entrevistas a profundidad realizadas a empresas con más de cien colaboradores ubicadas en Costa Rica, las cuales fueron analizadas con el software Atlas.TI8. Los resultados apuntan a que efectivamente existe la posible relación descrita, y cómo, a pesar de que se evidencia la relevancia que tienen las herramientas de mercadeo digital en la actualidad, existe una predominancia de las herramientas tradicionales. El análisis permite concluir que cada vez son más las compañías que manejan las herramientas de mercadeo digital a nivel interno dentro la organización, debido a la importancia de estas para el logro de los objetivos, además fue posible identificar que las empresas estudiadas han logrado un equilibrio entre mantener las actividades de mercadeo tradicional e incursionar en el uso del mercado digital.
Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients
Authors: Zhang Yan , Shi Yuanfei , Shen Huafei , Shou Lihong , Fang Qiu , Zheng Xiaolong , Zhu Mingyu , Huang Xin , Huang Jiansong , Li Li , Zhou De , Zhu Lixia , Zhu Jingjing , Ye Xiujin , Jin Jie , Xie Wanzhuo
Published: March 2021

Background Peripheral T-cell lymphoma(PTCL) is a group of lymphoproliferative tumors originated from post-thymic T cells or mature natural killer (NK) cells. It shows highly aggressive clinical behaviour, resistance to conventional chemotherapy, and a poor prognosis. Its incidence rate in China is 1 to 2 times higher than in western countries. Therefore, optimal strategies for identifying high-risk patients are urgently needed. Materials and Methods We retrospectively studied 347 newly diagnosed PTCL patients from January 2011 to October 2019 and analyzed the relationship between peripheral blood lymphocyte-monocyte ratio (LMR) and platelet-monocyte ratio (PMR) and prognosis. The model of Peripheral Blood Score was established to screen out high-risk patients. Results The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value based on survival rate. It was found that patients with PTCL with LMR ≤ 1.68 and PMR ≤ 300 had inferior overall survival (OS) and the difference was significant in both low-risk (P<0.001) and medium high-risk (P<0.001) groups of IPI score. In multivariate analysis, LMR ≤ 1.68 (HR=1.751, 95% CI 1.158-2.647, p=0.006), PMR ≤ 300 (HR=1.762, 95% CI 1.201-2.586, p=0.002), stage III-IV (HR=3.276, 95% CI 1.512-7.099, p=0.003), Eastern Cooperative Oncology Group (ECOG) score 3-5 (HR=2.351, 95% CI 1.647-3.356, p<0.001) and extra-nodal invasion more than one site (HR=1.659, 95% CI 1.125-2.445, p=0.039) were independently associated with short survival. LMR and PMR were integrated into "Peripheral Blood Score (PBS)" model. PTCL patients were divided into three risk groups: low-risk group, medium risk group and high-risk group. The 1-year OS was 86%, 55.3% and 22.6%, and the 3-year OS was 43.4%, 20% and 13.1%, respectively. Conclusion Overall, LMR and PMR can be used as early prognostic indicators in PTCL patients. Moreover, we can easily detect the complete blood cell count (CBC), and use PBS model to preliminarily screen and stratify patients. It is simple, convenient and accurate to screen out patients with short lives, and formulate personalized treatment strategies.
Characteristics, Comorbidities, and Outcomes Among Patients Admitted With COVID-19 in Sheikh Khalifa Medical City: A Retrospective Study
Authors: Abdelwahab Moustafa , Qadi Lara Al , Jawabreh Mohammad Al , Sulaiman Hanan , Blooki Mariam Al
Published: March 2021

Background: Many studies were published to describe the clinical characteristics of COVID-19, however there is still lack of knowledge and it’s time to take stock of the war against coronavirus disease 2019 (COVID-19) pandemic before we hit another million in a matter of days. Simply Identifying COVID-19 features will help in mapping the disease and guiding pandemic management. A retrospective review, retrospective study was initiated in SKMC to describe the demographic data, clinical characteristics, and outcomes of COVID-19 cases who were hospitalized during that period.Methods: Confirmed positive COVID-19 sample patients from April 1st 2020 to May 31st 2020 in Sheikh Khalifa Medical City. Clinical characteristics, Demographic data, incubation periods, laboratory findings, and patient outcomes data retrieved from 336 cases in the electronic medical chart (SALAMTAK).Results: The median age was 44 years and 83.9% (n = 282) of the patients were men. The patients with diabetes mellitus being the most common risk factor (25.0%), followed by hypertension (22.9%) and Age ≥60 were (13.4%). Total 36 patients (10.7%) were asymptomatic. The most common symptoms were upper respiratory tract symptoms, manifested as dry cough (70.2%), and followed by fever (54.2%), shortness of breath (43.5%), headache (25.9%) and sore throat (25.3%). Less common symptoms were diarrhea (16.7%) chest pain (14.6%). The maximum length of stay is 32 days. The minimum length of stay in [ICU/HDU] was 1 day and the maximum was 21 days.Conclusion: In this retrospective study, fever and cough were common symptoms. Special attention should be given to patients with risk factors especially patients with one risk factor such as diabetic patients, patients with hypertension and older patients over 60 years as they are the most highly prevalent in this case series. Disease was affecting males and D-dimer was significantly elevated in deceased patients.
Refractive Error Induced by Intraocular Lens Tilt After Intrascleral Intraocular Lens Fixation
Authors: TOKUHISA TERUAKI , WATANABE TOMOYUKI , WATANABE AKIRA , NAKANO TADASHI
Published: March 2021

Purpose To investigate the spherical shift of Intraocular lens (IOL) tilt after intrascleral fixationMethods We retrospectively reviewed the medical records of patients who underwent flanged intrascleral IOL fixation with transconjunctival 25- or 27-gauge pars plana vitrectomy at the Department of Ophthalmology of Jikei University Hospital with a minimum follow-up duration of three months. Second-generation anterior segment optical coherence tomography (CASIA2; TOMEY) was used to obtain the tilt and decentration of intrasclerally fixated IOL and postoperative anterior chamber depth. We investigated the relationship of the refractive error with these parameters, axial length, and keratometry. In addition to the clinical investigation, we performed optical simulations using the Zemax optical design program for studying the spherical shift of the IOL tilt by means of the through-focus response and change of spherical equivalent power.Results The study involved 72 eyes of 67 patients. The degree of IOL tilt was correlated with the amount of refractive error (Spearman's rank correlation coefficient [CC] = −0.32; P = 0.006). In particular, a tilt angle greater than 10° strongly influenced the refractive error. Postoperative anterior chamber depth also correlated with the refractive error (CC = 0.50; P < 0.001). The refractive error did not correlate with decentration (CC = −0.17; P = 0.15), axial length (CC = −0.08; P = 0.49), and keratometry (CC = −0.06; P =0.64). Optical simulations using the Zemax optical design program also showed a myopic shift exponentially as the tilt becomes greater. Conclusion An IOL tilt greater than 10 ° induces refractive error.
Quality of life of caregivers of patients with gastrointestinal cancer: The influence of sex, age, and stage of the cancer patients
Authors: Rosa Lilian Nascimento , Forones Nora Manoukian
Published: March 2021

Purpose: The caregivers of cancer patients may experience changes in their routine and environment that affect their quality of life. The aim of the study was to identify the domains that compromise the quality of life of the caregivers of patients with gastrointestinal cancer (GIC). Methods: A descriptive, observational study with caregivers of patients diagnosed with GIC during chemotherapy therapy was done. The caregivers answered 2 questionnaires, SF-36 (Short Form Health Survey 36) and CBS (Caregiver Burden Scale). Results: 100 caregivers of 100 patients with GIC were included. The mean age of the patients was 62.2±13 years. Most of them had colorectal cancer (66%), ECOG 0-1 (87%) and stage II/III (81%) disease. Among caregivers, 81% had less than 60 years old and 76% were female. According to the SF-36, lower levels were observed in the emotional, physical aspects and vitality and the best average in functional capacity. Regarding the CBS instrument, the general strain domain and disappointment was the more affected. Stage or ECOG was not associated to the caregivers QOL or burden. High schooling level of the patients was associated with a better quality of life and less burden of the caregivers. Ageing caregivers had a worst QoL and an increased burden.Conclusion: Most of caregivers were women and youngers and had a worst quality of life in emotional role, physical aspects and vitality and an increased burden in general strain and disappointment.
AI-guided use of balanced PPARα/γ dual agonist finetunes macrophage responses in inflammatory bowel disease
Authors: Katkar Gajanan , Sayed Ibrahim , Anandachar Mahitha Shree , Castillo Vanessa , Eleadah Vidales , Toobian Daniel , Usmani Fatima , Sawires Joseph , Leriche Geoffray , Yang Jerry , Sandborn William , Das Soumita , Sahoo Debashis , Ghosh Pradipta
Published: March 2021

A computational platform, the Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables querying and navigating invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease (IBD)-map and prioritize two nuclear receptors, PPARα/γ. Balanced agonism of PPARα/γ was predicted to impact macrophage processes, ameliorate colitis in network-prioritized animal models, ‘reset’ the gene expression network from disease to health, and achieve a favorable therapeutic index that tracked other FDA-approved targets. Predictions were validated using a balanced and potent PPARα/γ-dual agonist (PAR5359) in two pre-clinical murine models, i.e., Citrobacter rodentium-induced infectious colitis and DSS-induced colitis. Mechanistically, we show that such balanced dual agonism promotes bacterial clearance more efficiently than individual agonists both in vivo and in vitro; PPARα/γ is required and its agonism is sufficient to induce the pro-inflammatory cytokines and cellular ROS, which are essential for bacterial clearance and immunity, whereas PPARα/γ-agonism blunts these responses, delays microbial clearance and induces the anti-inflammatory cytokine, IL10. Balanced agonism achieved controlled inflammation while protecting the gut barrier and ‘reversal’ of the transcriptomic network. Furthermore, dual agonism effectively reversed the defective bacterial clearance observed in PBMCs derived from IBD patients. These findings not only deliver a macrophage modulator for use as barrier-protective therapy in IBD, but also highlight the potential of BoNE to accelerate and enhance the precision of drug discovery.
Accumulation, risk assessment of trace elements in soil-herbage systems and effects of elevation on subalpine grassland in the northeast of Tibet Plateau
Authors: Yang Qianfang , Wang Shengli , Zhao Cuicui , Nan Zhongren
Published: March 2021

Ecological environment of remote grassland has become increasingly serious in many countries due to mining, tourism, grazing and other human activities. In this study, a total of 15 pairs of soil-herbage samples were collected in the northeast of the Tibet Plateau to study the relationship between physicochemical properties and content of trace elements in soils and elevation, and to examine the accumulation and fractionation of heavy metals in soil-herbage systems. In addition, the ecological risk of the subalpine grassland was also assessed. The average concentrations of Hg, As, Cu, Zn, Pb, Cd, Cr and Mn in soil were higher than their background values of Gansu soil, but the average concentrations of these heavy metals in herbage satisfied Hygienical Standard for Feeds. The speciation analysis of heavy metals in soil indicated that the exchangeable content of heavy metal was very low, except Pb, Cd, Mn. There was a linear relationship between pH, CaCO3, total phosphorus (TP), organic matter (OM), concentrations of Hg, As, Zn, Pb, Cr and Mn in soils, dry weight of herbage and elevation, while there was a quadratic curve trend between Cu, Cd in soils and elevation. The results of risk assessment showed that there was no obvious ecological risk in the study area.
Effects of Inundation on Water Chemistry and Invertebrates in Floodplain Wetlands
Authors: Tsoi Wing (Iris) , Growns Ivor , Southwell Mark , Ryder Darren , Frazier Paul
Published: March 2021

Floodplain wetlands play a significant role in the storage of sediment and water and support high levels of nutrient cycling that lead to substantial primary production and high biodiversity. This storage, cycling and production system is driven by intermittent inundation. In regulated rivers the link between channel flows and floodplain inundation is often impacted with reduction in the frequency and duration of inundation. Managed floodplain inundation is us being used as a tool to help restore floodplain wetland processes and rehabilitate river systems. However, the use of managed water for the environment remains contentious and it is important to quantify the outcomes of re-introducing water to floodplain wetland systems. We examined the effects of environmental floodplain watering on water chemistry and three groups of invertebrates, including benthic and pelagic invertebrates and macroinvertebrates, in wetlands on the Gwydir River system in the north of the Murray-Darling Basin. We hypothesised that wetlands that were inundated for longer periods of time would have altered water chemistry and support a greater richness and abundance of invertebrates, thus altering their assemblage structures. Water chemistry and the assemblage structure of all three invertebrate groups in the wetlands was significantly influenced by the time since connection (TSC) to their respective rivers and therefore inundation period. The microinvertebrate abundance of was positively associated with TSC, but not macroinvertebrates. This suggests that the duration of connection between the channel and floodplain is important in maintaining the ecology and food webs in the wetlands.
Isovitexin, a main Flavonoid Compound from Celtis Sinensis Pers. Leaves, Exerts Activity Against Inflammation caused by Contacting Ginkgolic Acids in Ginkgo Fruit through Downregulating SHP2 Activation
Authors: zhang yiwei , qi zhipeng , wang wenjie , wang lei , cao Fuliang , zhao linguo , fang xianying
Published: March 2021

It has been reported that Celtis sinensis Pers. is employed as a folk medicine for the treatment of inflammation diseases. But the mechanism supporting its use as anti-inflammatory remain unclear. To investigate the anti-inflammatory of Celtis sinensis Pers. ICR mice were provided Celtis sinensis Pers. leaf extract (CLE) at 100, 200mg/kg after ginkgolic acids (GA) sensitization. Our data showed that CLE and the main flavonoid isovitexin in CLE could ameliorate GA-induced contact dermatitis in mice. Ear swelling, inflammatory cell infiltration and splenomegaly were inhibited significantly by isovitexin, while the weight loss of mice in the isovitexin-treated group was much better than that in the dexamethasone-treated group (positive control drug). It has been reported in previous research that GA-induced inflammation is closely related to the T cell response. Therefore, T cells were the focus of the anti-inflammatory effect of isovitexin in this paper. The in vivo results showed that isovitexin (10, 20mg/kg) inhibited the expression of proinflammatory cytokines (TNF-α, IFN-γ, IL-2 and IL-17A) in lymph nodes, inhibited the secretion of cytokines into the serum from mice with contact dermatitis and promoted the expression of apoptosis-related proteins. In vitro, isovitexin also induced apoptosis and proinflammatory cytokine expression in Con A-activated T cells. Further study showed that the MAPK and STAT signaling pathways and the phosphorylation of SHP2 were inhibited by isovitexin. Both molecular docking and biological experiments indicated that SHP2 may be an anti-inflammatory target of isovitexin in T cells. Taken together, isovitexin can serve as a potential natural agent for the treatment or prevention of GA-induced inflammatory problems.
Assessment of Landslide Susceptibility using Weight of Evidence and Frequency Ratio Model in Shahpur Valley, Eastern Hindu Kush
Authors: Rahman Ghani , Rahman Atta Ur , Bacha Alam Sher , Mahmood Shakeel , Moazzam Muhammad Farhan Ul , Lee Byung Gul
Published: March 2021

This study assessed landslide susceptibility using Weight of Evidence (WoE) and Frequency Ratio (FR) model in Shahpur valley, situated in the eastern Hindu Kush. Here, the landslides are recurrent phenomena that disrupt the natural environment and causes huge property damages as well as human losses every year. These damages are expected to increase due to the high rate of deforestation in the region, population growth, agricultural expansion and infrastructural development on the slopes. Initially, the landslide inventory map was prepared from the SPOT-5 satellite image and was verified from frequent field visits. Seven landslide contributing factors including surface geology, fault lines, slope aspect and gradient, land use, proximity to roads and streams were selected. To analyze the relationship between landslide occurrence with its causal factors, WoE and FR models were used. Based on WoE and FR model landslide susceptibility zonation maps were prepared and reclassified into very low to very high landslide susceptible zones. Finally, the resultant maps of landslide susceptibility were validated using the success rate curve and prediction rate curve approach to validate the models.
Awareness, Knowledge, Perceived Benefits, and Barriers Regarding Precision Medicine and Willingness to Participate in a National Registry: Comparison of Cancer Patients and the General Population
Authors: Lee Mangyeong , Cho Juhee , Kong Sun-Young , Yoon Junghee , Kang Danbee , Choi Kui Son , Shin Soo-Yong , Seo Hwa Jeong , Jung So-Youn , Lim Myong Cheol , Lee Eun Sook , Chang Yoon Jung
Published: March 2021

Background
Precision medicine (PM) is a growing area of interest in cancer care. However, relatively little is known about the public attitudes toward PM and the factors associated with the willingness to participate in the construction of national registries for PM.
Methods
A cross-sectional survey was conducted with 1,500 cancer patients and 1,496 general population in South Korea from November 2016 to February 2017. We evaluated cancer patients’ awareness, knowledge, as well as perceived benefits and barriers regarding precision medicine (PM), and their willingness to participate in a national registry for PM, compared to the general population. Logistic regression analysis was performed to identify the factors associated with the willingness to participate in a national registry for PM.
Results
1,500 cancer patients and 1,496 general population were recruited for the study. Cancer patients were less likely to have heard of PM than the general population (20.0% and 33.1%, P < .001), 34.2% of the participants knew the correct definition of PM. Cancer patients were more likely to However, fewer study participants in both groups said they would like to share their personal health data for PM, compared to the number of people who are willing to participate. Cancer patients (aOR 2.98, 95% CI, 2.47–3.61), participants who had heard of PM before (aOR 1.40, 95% CI, 1.00-1.95), had greater perceived benefits (aOR, 2.48, 95% CI, 1.88–3.27) and fewer perceived barriers (aOR 1.57, 95% CI, 1.18–2.08) regarding PM were more likely to have the willingness to participate in the registry compared to those who did not.
Conclusions
Cancer patients were more likely to have greater perceived benefits of PM and higher willingness to participate in the related study than the general population. However, both two groups were still informed about PM well. This study suggests considering the provision of information and education about PM such as expected values and required roles both to the general population and cancer patients.
Capsulorhexis Under Continuous Fluid Pressure in Intumescent Cataracts: A New Technique
Authors: UÇAR Fikret
Published: March 2021

Purpose: To evaluate the effectiveness of the anterior capsulorhexis technique under continuous fluid pressure with anterior chamber maintainer in intumescent cataracts.Methods: Scheduled for phacoemulsification due to intumescent cataracts, 84 eyes of 84 patients were included in the study. An anterior chamber maintainer, which provided continuous fluid pressure in the anterior chamber, was placed in the patients of Group 1 (n = 42). Capsulorhexis without viscoelastic was then applied under continuous fluid pressure. In Group 2 (n = 42) patients, capsulorhexis was performed by utilizing an ophthalmic viscoelastic device (OVD) to the anterior chamber. The efficiency and reliability of our capsulorhexis method were evaluated by comparing the intraoperative and postoperative complications that occurred in such cases.Results: Radial tear did not occur in any of the cases in the capsulorhexis stage in Group 1; however, 6 Group 2 patients were observed to have radial tears(p<0.05). Progression of the anterior capsule, which did not turn into a radial tear, to the periphery was observed in 2 patients in Group 1, and 8 patients in Group 2(p<0.05). When liquefied cortical material egress dynamics were evaluated; the controlled fluid output was observed in 41 patients (97.61%) in Group 1, and 29 patients (69.4%) in Group 2 (p<0.001). There was no statistically significant difference revealed between the two groups in the endothelial cell loss (p> 0.05).Conclusion: The technique we used provides a controlled and safe capsulorhexis in intumescent cataracts, reduces surgical complications, and does not require any additional cost.
Formability and interface structure of Al/Mg/Al composite sheet rolled by hard-plate rolling (HPR)
Authors: Huo Peng Da , Li Feng , Wang Ye , Xiao Xing Mao
Published: March 2021

How to improve the bonding ability and quality perform between heterogeneous plates has always been one of the difficult issues that have long been concerned in the field of high-performance heterogeneous composite plate forming and manufacturing. This paper proposes a new method for manufacturing heterogeneous composite panels—composite panels by hard-plate rolling (HPR). In addition to adding hard plates above and below the aluminum/magnesium/aluminum (Al/Mg/Al) composite slab, the research results of the hot rolling process of the composite plate with or without the hard plates at 40%, 60%, and 80% reduction show that the hard plates can be rolled During the manufacturing process, the shear stress in the rolling direction (RD) is partially converted into the compressive stress in the normal direction (ND), which then increases the welding pressure between the heterogeneous composite laminates, which can inhibit the occurrence of bending and edge cracks, and significantly improve the quality and shape of the board ability. At the same time, through the study of the interface structure of the composite plate, it can be known that metallurgical bonding can be achieved with a small reduction after the addition of the hard-plate, and two clear layers of Al3Mg2 and Al17Mg12 intermetallic compounds appear at the Al/Mg interface, and the thickness of the diffusion layer is uniform. Significantly larger than the traditional hot-rolled composite board, the thickness of the diffusion layer can reach 38µm under the condition of 60% reduction under the action of the hard-plate, the yield strength is 172.3MPa, and the elongation reaches 21.5%. In summary, the hot-rolled by hard-plate is high forming and manufacturing of performance heterogeneous composite panels provides a method.