bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease and Diabetes Mellitus: A Subgroup Analysis of the ADAPTABLE Trial
Authors: Narcisse Dennis I. , Kim Hwasoon , Wruck Lisa M. , Stebbins Amanda L. , Muñoz Daniel , Kripalani Sunil , Effron Mark B. , Gupta Kamal , Anderson R. David , Jain Sandeep K. , Girotra Saket , Whittle Jeff , Benziger Catherine P. , Farrehi Peter , Zhou Li , Polonsky Tamar S. , Ahmad Faraz S. , Roe Matthew T. , Rothman Russell L. , Harrington Robert A. , Hernandez Adrian F. , Jones W. Schuyler
Published: September 2023

OBJECTIVE

Patients with diabetes mellitus (DM) and concomitant atherosclerotic cardiovascular disease (ASCVD) must be on the most effective dose of aspirin to mitigate risk of future adverse cardiovascular events.

RESEARCH DESIGN AND METHODS

ADAPTABLE, an open-label, pragmatic study, randomized patients with stable, chronic ASCVD to 81 mg or 325 mg of daily aspirin. The effects of aspirin dosing was assessed on the primary effectiveness outcome, a composite of all-cause death, hospitalization for myocardial infarction, or hospitalization for stroke, and the primary safety outcome of hospitalization for major bleeding. In this prespecified analysis, we used Cox proportional hazards models to compare aspirin dosing in patients with and without DM for the primary effectiveness and safety outcome.

RESULTS

Of 15,076 patients, 5,676 (39%) had DM of whom 2,820 (49.7%) were assigned to 81 mg aspirin and 2,856 (50.3%) to 325 mg aspirin. Patients with versus without DM had higher rates of the composite cardiovascular outcome (9.6% vs. 5.9%; P < 0.001) and bleeding events (0.78% vs. 0.50%; P < 0.001). When comparing 81 mg vs. 325 mg of aspirin, patients with DM had no difference in the primary effectiveness outcome (9.3% vs. 10.0%; hazard ratio [HR] 0.98 [95% CI 0.83–1.16]; P = 0.265) or safety outcome (0.87% vs. 0.69%; subdistribution HR 1.25 [95% CI 0.72–2.16]; P = 0.772).

CONCLUSIONS

This study confirms the inherently higher risk of patients with DM irrespective of aspirin dosing. Our findings suggest that a higher dose of aspirin yields no added clinical benefit, even in a more vulnerable population.
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis
Authors: Devesa Ana , Fuster Valentin , Vazirani Ravi , García-Lunar Inés , Oliva Belén , España Samuel , Moreno-Arciniegas Andrea , Sanz Javier , Perez-Herreras Cristina , Bueno Héctor , Lara-Pezzi Enrique , García-Alvarez Ana , de Vega Vicente Martínez , Fernández-Friera Leticia , Trivieri Maria G. , Fernández-Ortiz Antonio , Rossello Xavier , Sanchez-Gonzalez Javier , Ibanez Borja
Published: September 2023

OBJECTIVE

Experimental evidence suggests that metabolic syndrome (MetS) is associated with changes in cardiac metabolism. Whether this association occurs in humans is unknown.

RESEARCH DESIGN AND METHODS

821 asymptomatic individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study (50.6 [46.9–53.6] years, 83.7% male) underwent two whole-body 18F-fluorodeoxyglucose positron emission tomography-magnetic resonance (18F-FDG PET-MR) 4.8 ± 0.6 years apart. Presence of myocardial 18F-FDG uptake was evaluated qualitatively and quantitatively. No myocardial uptake was grade 0, while positive uptake was classified in grades 1–3 according to target-to-background ratio tertiles.

RESULTS

One hundred fifty-six participants (19.0%) showed no myocardial 18F-FDG uptake, and this was significantly associated with higher prevalence of MetS (29.0% vs. 13.9%, P < 0.001), hypertension (29.0% vs. 18.0%, P = 0.002), and diabetes (11.0% vs. 3.2%, P < 0.001), and with higher insulin resistance index (HOMA-IR, 1.64% vs. 1.23%, P < 0.001). Absence of myocardial uptake was associated with higher prevalence of early atherosclerosis (i.e., arterial 18F-FDG uptake, P = 0.004). On follow-up, the associations between myocardial 18F-FDG uptake and risk factors were replicated, and MetS was more frequent in the group without myocardial uptake. The increase in HOMA-IR was associated with a progressive decrease in myocardial uptake (P < 0.001). In 82% of subjects, the categorization according to presence/absence of myocardial 18F-FDG uptake did not change between baseline and follow-up. MetS regression on follow-up was associated with a significant (P < 0.001) increase in myocardial uptake.

CONCLUSIONS

Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.
Investigations on improving the properties of laser beam welded thick dissimilar joints of steel and aluminum by using filler material
Authors: Lahdo Rabi , Nothdurft Sarah , Seffer Oliver , Hermsdorf Jörg , Kaierle Stefan
Published: September 2023

Thick dissimilar joints of steel and aluminum are still of high interest for shipbuilding in order to reduce the weight and the center of gravity of the ship. Thereby, a reduction of the CO2 emissions as a result of lower fuel consumption and a higher ship stability are achievable. The steel and aluminum ship parts are joined with the aid of an explosive-welded adapter, whose manufacturing is complex, time-consuming, and expensive. Furthermore, the adapter must be oversized to meet strength requirements. Therefore, the shipbuilding industry demands a better alternative. In this study, laser beam welding processes are developed for joining steel S355 J2 (t = 5 mm) with aluminum alloy AA6082-T651 (t = 10 mm) in a lap configuration using a laser beam source with a maximum output power of PL = 6 kW. Laser beam welding of this dissimilar material combination brings certain challenges, such as the formation of brittle microstructures in the weld metal depending on the aluminum content. To improve the microstructure and the associated mechanical properties of the weld seam, a filler material in the form of iron welding powder is used. The welding powder is provided in a groove in the aluminum bottom sheet. In this way, an iron-rich microstructure results, which leads to an increase in the weld seam quality, as shown in metallographic analysis and tensile tests. For example, the cross tension force can be increased by 100%.
The Impending Population Decline in Northern Norway: Implications and Demographic Challenges
Authors: Vennerød Øyvind , Scjøtt-Pedersen Karl Eirik
Published: September 2023

This study presents an analysis of population trends in rural Norway, with a specific focus on the potential implications for rural populations in a long-term perspective. We highlight the significant outward migration of young people from rural areas, which has led to a demographic shift happening at a faster pace and on a larger scale in rural areas compared to central areas. Using North-Varanger, the most north-eastern part of the country, as an example, the article shows that the region has experienced net outward migration for the past 50 years, and if current trends persist, the population in the region could decrease by up to 80 percent by 2100. North-Varanger is an area of strategic importance to Norway. It is also an area of vital importance for the Sami people. This study shows that there is a risk that the population in one of the most strategically important regions will see a dramatic reduction. The only way to reverse this trend is to change the migration patterns and encourage more young families to settle in North-Varanger. This stresses the urgent need for policymakers to re-evaluate current public measures aimed at attracting migrants to rural areas in order to make the measures more effective and to ensure sustainable settlement in the region.
AL-QUR'AN'S SOLUTION IN THE QUARTER LIFE CRISIS PHASE TO ANXIETY (THEMATIC STUDY OF THE QUR'AN)
Authors: Muhajir Ahmad , Tulic Sadzid
Published: September 2023

Human life is not without problems. When problems arise, humans tend to feel anxiety, stress, or even other illnesses that often result in confusion about what is the right solution to solve the problem. even though Allah SWT, in the Al-Qur'an has included many verses that provide solutions for all kinds of anxiety. One example of life anxiety is the quarter life crisis or a quarter century crisis. who feel worried about the future, have no clear direction, confused and distraught about the uncertainty. Usually this anxiety includes relationships, romantic relationships, careers, and social life. Based on this phenomenon mentioned, the author tries to further examine the Qur'an's solutions to the quarter life crisis phase. The method used to analyze the Al-Qur'an's solution to future anxiety uses thematic study of the Qur'an or commonly called maudhu'i. namely finding and collecting verses that contain anxiety and verses that provide solutions to anxiety in the Qur'an. The result of the research is that anxiety is not specifically discussed in the Qur'an, but reflects a broad implied value including its meaning. 1. Khauf, namely the state of the heart, there is no peace about something in the future 2.diiq namely the narrowness of the soul, triggered by doubts originating in the heart, 3.Halu’a namely the nature of complaining, and 4.huzn that is sad. Then the solutions in the Qur'an to avoid anxiety include: Striving hard to look at the future, Continuously trying to follow Allah's instructions, Istiqomah in goodness, Sincere, Reaching for the future with faith, piety and good deeds.
Flowering Behavior, Fruit Harvesting Age and Proximate Levels of the Flesh of the West Sumatera Superior Avocado
Authors: Ihsan Farihul , Hardiati Sri , Putu Indriyani Ni Luh
Published: September 2023

The aim of this study was to determine flowering behavior, fruit harvesting age and proximate levels of the flesh of the four West Sumatera superior avocado varieties, i.e: Mega Gagauan, Mega Murapi, Mega Paninggahan and Tongar. The research was conducted in Indonesian Tropical Fruit Research Institute from October 2020 to August 2022. The plant materials was used Mega Gagagauan, Mega Murapi, Mega Paninggahan and Tongar which 2 trees each variety. Parameters observed i.e: flower type, blooming time, fruit age, fruit character, and proximate content of flesh. Data were analyzed descriptively. The results showed that Mega Gagauan, Mega Murapi and Mega Paninggahan had type B flowers, while Tongar had type A flowers. The time difference between the first and second blooms on the same day for Mega Gagauan and Mega Murapi was 1 and 2 hours, while there is no time difference in Mega Paninggahan and Tongar. The fruits harvesting age of Mega Gagauan, Mega Murapi, Mega Paninggahan, and Tongar are i.e: 161; 232; 160; and 170.42 days. Tongar had the lowest water content (73.83%) and the highest fat (15.30%), Mega Murapi had the lowest crude fiber content (2.82%), and Mega Paninggahan had the highest protein content (1.87%).  Mega Paninggahan was considered the best variety based on the observed character and this research data can be used as the basic for determining actions of cultivating avocado plant.
Payments and Foreign Exchange Regulation under the Sanctions Regime: Legal Aspect
Authors:   Financial University under the Government of the Russian Federation, Arutyunyan Artak V.
Published: September 2023

The modern realities of business structures are characterized by extremely difficult conditions due to the restric-tive economic measures imposed by Western countries on the Russian Federation as a sign of non-acceptance of its foreign economic paradigm. The study outlines areas for improvement of the Russian financial system on the basis of the analysis of the sanctions imposed and their impact on the possibility of cross-border payments. The legal aspects of the regulation of digital assets are considered through the prism of Russian and foreign legislation, the advantages of their use and legalization as a payment instrument are highlighted. It is proposed to create a special economic zone for the implementation of digital currency settlements using tokens. In conclusion, this form of payment organization allows to apply an experimental legal regime, to develop pro-prietary mechanisms of admission to the market of digital currencies and tokens, taking into account all the functioning features of the international financial center.
Quality of Life Concept as the Ideological and Political Basis for Sustainable Development
Authors:   St. Petersburg State University, Argvliani Karina R.
Published: September 2023

The quality of life concept, which developed in the mid-XXth century as a response to the redefinition of the val-ues of mass consumption society, is increasingly important in international relations nowadays. Despite a sig-nificant shift in the theoretical approach to defining the term quality, there is still no unified methodology that would make it possible to assess the quality of life of the population most fully and accurately. When compiling indices, it is important to involve a large number of people in the process of subjective analysis of the quality of their own lives. The aim of the article is to confirm the increasing role of quality of life indicators in international relations. The object of the study is the UN policy on the implementation of statutory principles. The subject is the political attitudes to the development of quality of life indices. The novelty of the work is the complex ap-proach to the study of the quality of life concept in international relations. The novelty of the work is the complex approach to the study of the quality of life concept in international relations. Using the example of various methods of indexing the state of the world society, it shows how the priorities are gradually changing: moving away from the dominance of economic indicators (GDP) and refocusing on others, fixing the socio-political realities of the Earth’s population quality of life.
Public Control over Branches and Representative Offices of International Non-Governmental Organizations in Russia
Authors:   Independent Researcher, Goncharov Vitaly V.
Published: September 2023

The present paper aims to investigate the necessity of organization and implementation of public control in the Russian Federation over branches and representative offices of international non-governmental organizations. The work justifies the role and place of the institute of public control in the system of legal guarantees of im-plementation and protection of both the system of constitutional principles and the entire system of rights, free-doms and legitimate interests of Russian citizens. The author argues for the idea that the system of objects of public control, stipulated by law, should include the activities, acts and decisions of branches and representa-tive offices of international non-governmental organizations. The paper formalizes and explores the main modern problems that hinder the organization and implementation of public control over branches and repre-sentative offices of international non-governmental organizations. The author devises a system of proposals and recommendations for solving the above-mentioned problems, including by introducing amendments and additions to the Constitution of the Russian Federation and the current legislation.
Xi Jinping’s “Deadline” Thinking in Government
Authors:   Peoples’ Friendship University of Russia, Tian Miao
Published: September 2023

The paper shows the necessity of using the “deadline” thinking approach in public administration, supported by the facts of the state of the current international situation and the internal factors that are developing in Chinese society. The challenge of this paper is to reveal the essence of Xi Jinping’s “deadline” thinking approach in governmental organization. The aim of the study is to discuss Xi Jinping’s current public policy as an example of a productive manifestation of “deadline” thinking in political decision-making. The article uses theoretical research methods (analysis, synthesis) and presents structured material – the experience of using Xi Jinping’s “deadline” thinking in the state structure. It is demonstrated that in governing China, due to “deadline” thinking, the formation of a strategy for building socialism with Chinese specificity on the basis of overcoming complex domestic and international situations is actively taking place. The relevance of using this type of thinking is justi-fied by Xi Jinping as a struggle against negative manifestations in Chinese society, which are obstacles in building socialism with Chinese specificity – corruption, weak scientific and technological potential, factors threatening public security. Such a bottomline (deadline) concept, according to Xi Jinping, will strengthen the Party’s performance and enhance its legitimacy. As part of his activities, Xi Jinping also makes proposals, spe-cific and targeted – the fight against bureaucracy and formalism, setting the level of official morality, tightening party discipline, and preventing criminal violations within parties. One of Xi Jinping’s strengths is not only dis-cussion, but also concrete proposals for reform of the economic system, reform of the ecological system, re-form of the political system, and reform of the social and cultural system.
Diagnosis of Core Production Dependence on Production Infrastructure Based on Ensemble Method of Machine Learning
Authors:   Kazan National Research Technological University, Shinkevich Aleksey I. , Malysheva Tatyana V. ,   Kazan National Research Technological University
Published: September 2023

The rational organization of the production infrastructure of an industrial enterprise has a significant impact on the level of profitability of production. New technologies for integrating business processes are evolving in the face of industrial automation. The aim of the article is to diagnose the level of economic dependence of the core production on the production infrastructure. As a research method, the algorithm of the ensemble method of machine learning “Random Forest” is proposed. The parameters that quantitatively and qualitatively describe the costs of main and auxiliary production, the costs of repair facilities, and the level of production efficiency have been developed. Approbation of the algorithm on the example of chemical enterprises allowed distin-guishing three classes of productions by the nature of the organization of production infrastructure and its par-ticipation in the core production. The quality of the obtained models is evaluated by calculating the risk of mis-classification and the magnitude of cumulative lift, where the class with the most correct classification results is highlighted. Results obtained are primary diagnostics of the organization and capacity utilization of the produc-tion infrastructure in order to make decisions on business process restructuring.
Interaction between the Judiciary and Political Processes: Analyzing the Impact of Political Factors on the Professional Training of Specialists
Authors:   Russian State University of Justice, Bondarev Viktor G. , Tsyplakova Ekaterina P. ,   Russian State University of Justice
Published: September 2023

The interaction between the judiciary and political processes has many dimensions, such as the appointment of judges, political attitudes, the training of judicial professionals, support for their professional development, the influence of political forces and groups on judicial processes and the enforcement of judicial decisions. Examining these linkages allows for a better understanding of the complexity and dynamics of the relationship between the judiciary and the political sphere, as well as identifying possible challenges and problems faced by professionals in the judiciary. The article analyzes the mechanisms by which political processes affect the professional training and development of judicial professionals, such as political appointments, legislative changes, public policy, funding, and other factors. Examples of the impact of political factors on the judiciary are given, highlighting negative and positive aspects. The authors emphasize the importance of maintaining the independence, objectivity and competence of judicial training and the need to continuously monitor and respond to changes in the political environment.
On the Issue of Digitalization Policy and its Impact on the Education System in the All-Russian Context (Threats and Risks)
Authors:   Baltic State Technical University “VOENMEH” named after D.F. Ustinov, Forostiannyi Nikita S. , Sukhova Anna A. ,   Baltic State Technical University “VOENMEH” named after D.F. Ustinov, Bragin Artem R. ,   St. Petersburg State University
Published: September 2023

The paper argues for the idea that the education system influences managerial decision-making at the public and private levels, which ultimately determines the society’s quality of life and the state of the country’s security. Hence, it seems important to study the process of digitalization, which has changed and is changing all spheres of society, including the educational process. Studying the process of digitalization of education means con-ducting various kinds of monitoring, assessments and ratings that reflect the level of development of digital transformation and the impact on the quality of educational services. The use of digital technologies ensures both the satisfaction of the growing needs of modern society and its socio-economic development. Neverthe-less, the active process of digitalization carries potential threats and risks that need to be taken into account when implementing the digital transformation strategy in all object sectors.
Actitudes e ideologías lingüísticas hacia las lenguas qom y español en Colonia Aborigen Chaco, Argentina
Authors: Paredes Agustina
Published: September 2023

En este artículo se exponen los últimos avances realizados en una investigación de doctorado que se inserta en el marco teórico de la lingüística antropológica y parte del trabajo de campo etnográfico en una comunidad indígena argentina, localizada entre las ciudades de Machagai y Quitilipi (Chaco). Se trata del grupo indígena qom situado Colonia Aborigen Chaco. Con este trabajo se pretende contribuir a la reflexión sobre la situación sociolingüística de dicha comunidad. Para ello, se hace foco en las actitudes e ideologías lingüísticas que los indígenas tienen sobre las lenguas qom y español para finalmente presentar las conclusiones esbozadas hasta el momento.
Maternidad y consumo problemático de sustancias: abordajes en un Hospital General de Agudos
Authors: Doubik Emilia
Published: September 2023

A partir de mi rotación como residente de Trabajo Social por la Sala de Internación de Maternidad de un Hospital General de Agudos- zona sur de CABA- durante el período de abril y mayo de 2022, me propuse a través del presente trabajo, analizar y reflexionar en torno a la manera en que les[1] profesionales de salud, principalmente de la disciplina Trabajo Social, abordan las situaciones de mujeres que ingresan al hospital por el nacimiento de su hije y se encuentran en situación de consumo de sustancias psicoactivas. E indagar si tales profesionales identifican obstáculos al momento de intervenir sobre dicha problemática en un contexto hospitalario.
[1] El lenguaje inclusivo es una herramienta que tiene como objetivo reconocer al género femenino y LGTBI+, en contraposición, al discurso lingüístico que históricamente estuvo asociado al masculino, invisibilizando tales géneros. Es un modo de comunicación que busca desarmar estereotipos y alcanzar mayores estándares de igualdad.
Intelligent, Variable-rate Spray Technology Reduces Total Pesticide Output while Controlling Foliar Disease of Shumard Oak
Authors: Fessler Lauren , Xiaocun Sun , Wright Wesley C. , Zhu Heping , Fulcher Amy
Published: September 2023

Air-blast sprayers have known inefficiencies in nursery production systems. Intelligent, variable-rate spray technology aims to improve application accuracy and reduce total pesticide consumption by utilizing pulse-width modulated solenoid valves, laser scanning and ground speed sensors, and a computerized algorithm to customize spray output based on plant presence, size, shape, and density. This study used an air-blast sprayer retrofitted with this variable-rate spray technology to directly compare spray characteristics and pest control of the sprayer operated in intelligent, variable-rate mode and conventional, constant-rate mode to spray trees grown in 57 L (15 gal) containers in a multi-row pot-in-pot production system. Variable-rate mode reduced total spray volume by 43% while providing equivalent, and at times better, disease control compared to the constant-rate mode for two fungal borne diseases of Shumard oak (Quercus shumardii Buckley). This research demonstrates the capability of variable-rate technology to reduce input costs, environmental harm, and risk of pesticide exposure while simultaneously controlling disease and maintaining saleable crops.

Species used in this study: Shumard oak (Quercus shumardii Buckley).
Histology of Adventitious Root Formation and Phytohormone Analysis of American Chestnut Cuttings
Authors: Lu Xinya , Cuarto Maxine , Liang Haiying
Published: September 2023

The formation of adventitious roots (ARs) is a complex process. It plays an important role in the successful production of elite clones since it is a key step in the vegetative propagation of economically important horticultural woody species. The American chestnut (Castanea dentata) is a heritage species and is notoriously recalcitrant to stem rooting. As part of the efforts to understand American chestnut cuttings’ recalcitrance, we examined AR formation via histology and compared the phytohormone level profile between American chestnut and easy-to-root poplar cuttings (Populus x euramericana). It was found that ARs could be induced directly from American chestnut cuttings without callus formation. Adventitious roots of American chestnut were initiated from cambial derivatives and developed a vascular system connected with that of the stem. Compared to easy-to-root poplar, American chestnut cuttings had a low level of indole-3-acetic acid (IAA) and a high level of cytokinin (CK), abscisic acid (ABA), salicylic acid (SA), jasmonic acid (JA), and oxylipin 12-oxo-phytodienoic acid (OPDA). Hormone distribution between leaves and stems also differed between American chestnut and poplar. This unfavorite endogenous hormone profile may contribute to American chestnut cuttings’ recalcitrance to rooting.

Species used in this study: American chestnut [Castanea dentata (Marsh.) Borkh.], poplar (Populus x euramericana).

Chemicals used in this study: 1-Naphthaleneacetic acid (NAA).
Macrophage phenotype impacts in vitro equine intrasynovial deep digital flexor tenocyte matrix metalloproteinase gene expression and secretion
Authors: Cooper Hannah E. , Bowlby Charles , Long Sidney , Durgam Sushmitha S.
Published: September 2023

OBJECTIVE

To investigate matrix metalloproteinase (MMP) and their inhibitors tissue inhibitor matrix metalloproteinase (TIMP) gene expression and secretion during equine deep digital flexor tendon (DDFT) tenocyte and macrophage (undifferentiated, proinflammatory, and regulatory) co-culture.

SAMPLE

Third passage DDF tenocytes and donor-matched macrophages differentiated from peripheral blood CD14+ monocytes from 5 healthy horses ages 9–11 years, euthanized for reasons unrelated to musculoskeletal conditions.

METHODS

Passage 3 DDT tenocyte aggregate cultures were co-cultured with undifferentiated (control), proinflammatory (granulocyte-macrophage colony-stimulating factor; GM-CSF pretreated and lipopolysaccharide + interferon gamma-primed; LPS+IFN-γ) or regulatory (interleukin-4 and interleukin-10-primed; IL-4 + IL-10) macrophages in direct and transwell co-cultures for 72 hours. MMP-1, -2, -3, -9, -13, and TIMP -1, -2 mRNA were measured via real-time Polymerase Chain Reaction (rtPCR). Co-culture media MMP -3, -9, and TIMP -1, -2 concentrations were quantified via ELISA.

RESULTS

Direct co-culture of DDF tenocytes with proinflammatory macrophages for 72 hours increased MMP-1, -3, and -13 mRNA levels whereas, MMP-9 mRNA levels decreased. Direct and transwell co-culture with proinflammatory and regulatory macrophages resulted in increased MMP-3 and decreased MMP-9 media concentrations. While direct co-culture with regulatory macrophages significantly increased TIMP-1 mRNA, overall, TIMP mRNA and culture media concentrations were largely unchanged.

CLINICAL RELEVANCE

Cell-to-cell contact between DDF tenocytes and macrophages is not essential to induce MMP gene expression and secretion. Co-culture systems offer a viable in vitro platform to screen and evaluate immunomodulatory properties of therapies aimed at improving equine intrasynovial tendon healing.
The Impact of Inflation and Exchange Rates on Generating Power of Cash in Egypt (Panel Data Analysis)
Authors: Elewa May Mahmoud , Abdel aal Yasmin Abdel aal Mahmoud , Mahmoud Nevin Hussein Mohamed
Published: September 2023

Objective –The objective is to study the effect of the sharp change in currency exchange rate EXR and inflation on generating power of cash GPC in light of Egyptian Accounting standards EAS in the progressing Egyptian industry setting.Methodology –The methodology consists of careful examination of the numerical evidence and analysis of the changes in the relevant accounting standards and regulations. The study used numerical data from 38 non-financial firms for 5 years corresponding to 190 firm year observations during 2017-2021. The study applies the panel data method. The designated sample of firms are listed on the EGX 100, have yearly financial statements, have not discontinued during the study period, run in cash, the currency is recorded in the Egyptian pound, and have complete data. The study applies multiple regressions. It applied fixed effects, random effects, and pooled models. The study includes the dependent variables of the generating power of cash GPC. The study also includes the independent variables; exchange rates EXR and inflation rates.Results –Findings indicate a significant relationship among; inflation, EXR andGPC. Findings offer new perceptions for investors and policy makers concerned with EXR and inflation.Research limitations/implications –Much of the information is available. However, the time span of the study allows for tracking the impact of inflation and change in EXR on firm GPC.Novelty/Originality –The originality lies in setting an accounting standard for inflation tailored for the Egyptian business environment that adapts the available accounting information to the current economic situation.
Behavioral lifestyles and motivations for adopting a vegetarian style among under-graduate students from the State of São Paulo, Brazil.
Authors: Maestre Sofia , Mazzeo Isabela , Leme Ana Carolina , Fisberg Mauro
Published: September 2023

OBJECTIVE: Young adults have gained recognition as a period marked by changes in dietary and other lifestyle behaviors. The aim was to characterized young adults as meat and non-meat consumers and examine non-meat consumers associations between lifestyle behaviors, reasons, and motivations for adhering to vegetarian styles. METHODS: cross-sectional analysis with 692 college students from 18 to 25 years old. Participants reported socio-demographic and lifestyle characteristics. Non-meat consumers questionnaire was related to aspects of adhering a vegetarian style, and they were classified as difficulties, positive and negative aspects of adhering it. Questions related to overall health were asked. Descriptive analysis and logistic regressions were used for analyses. RESULTS: The majority of the study participants were female (79.2%) with mean age of 21.2±0.07 years. Almost 18% of the participants were non-meat consumers, from those, 78.9% reported themselves as ovo-lacto-vegetarian. Meat consumers had a higher probability for practicing less physical activity (PA) (OR 1.51; 95%CI 1.01, 2.27) and being less underweight (OR 0.22; 95%CI 0.10, 0.49) or normal weight (OR 0.48; 95%CI 0.28, 0.84) as compared to non-meat consumers. Ovo-lacto-vegetarian was more likely to reduce industrialized items (OR 3.69; 95%CI 1.18, 11.56) and less willing to do things (OR 0.10; 95%CI 0.01, 0.52) than vegan adults. Conclusion: Most participants were meat-consumers and had higher chances of not practicing PA and being more overweight. Vegans might be consuming more industrialized foods and were more willing to do things. Future studies should be considered to increase data generalizability in Brazil and other countries.
Síndrome coronario agudo recurrente tras infusión de infliximab en paciente con artritis reumatoide
Authors: Rebolledo Del Toro Martin , Borda Camila , Rincón Luisa Fernanda , Castillo Andrea , Fernández-Ávila Daniel Gerardo
Published: September 2023

Descripción del caso:Paciente masculino de 61 años con artritis reumatoide no controlada, en manejo con infliximab, quién presentó en tres oportunidades síndrome coronario agudo menos de 48 horas posterior a la aplicación del medicamento.
Hallazgos clínicos:Presentó infarto con elevación del ST en dos ocasiones y síndrome coronario agudo sin elevación del ST en una oportunidad, encontrándose enfermedad coronaria multivaso.
Tratamiento y resultado:Se realizó intervención coronaria con tromboaspiración, implante de stents medicados y angioplastia con balón medicado, suspensión del infliximab y modificación y optimización de manejo farmacológico cardiovascular.
Relevancia clínica:Los pacientes con artritis reumatoide tienen enfermedad cardiovascular subclínica y mayor riesgo cardiovascular. La evidencia respecto a la relación entre infliximab y cardiopatía isquémica es controversial. En reportes de caso se encuentra un amplio espectro clínico de compromiso cardíaco con la infusión de infliximab, que va desde la angina estable hasta el síndrome coronario agudo con elevación del segmento ST. La fisiopatología no está claramente dilucidada, con hipótesis que proponen la ruptura de placa, reacciones alérgicas y la vasoconstricción como posibles mecanismos de enfermedad. La asociación directa entre la infusión de infliximab y el síndrome coronario agudo necesita más investigación clínica con el fin de optimizar el manejo y pronóstico de los pacientes que presentan este tipo de complicaciones.
Physiologia e ética:
Authors: Rocha Everton da Silva
Published: September 2023

Abordaremos nesse artigo o problema da coerência no pensamento de Epicuro e de sua unidade sistemática. A partir de críticas feitas contra o epicurismo ao longo da tradição pretendemos voltar aos textos fundamentais atribuídos a Epicuro e apresentar argumentos que demonstrem em Diôgenes Laêrtios, nas cartas e máximas uma unidade sistemática, que perpassa todo o conjunto da obra epicúrea.  Defenderemos o posicionamento que physiologia e ética seriam separadas apenas para efeitos didáticos e teóricos. Na realidade elas fazem parte de um mesmo sistema filosófico. A continuidade entre physiologia e ética seria demonstrada nas posições epicúreas relacionadas aos problemas dos fenômenos celestes, dos limites para as dores e os prazeres, e principalmente da morte.
Clinamen, necessity and modern receptions of epicureanism:
Authors: Fytakis Kyriakos
Published: September 2023

Early modern readings of Epicureanism carried various prejudices and the term epicurean often designated an impious and potentially dangerous thinker. This was the case for Dutch philosopher Baruch Spinoza whose contemporaries compared his doctrine to Epicureanism on several occasions. However, how accurate would it be to affirm that Spinoza’s philosophy belongs to the neo-epicurean tradition? We find such a comparison in many 17th and 18th century texts, especially in works written by critics of his thought, such as François Fénelon or Jean La Placette. Epicurean doctrine on chance was compared to Spinoza’s theory on necessity, but despite the prejudices of the comparison, both Epicurus’s and Spinoza’s philosophies had an important influence on the Enlightenment, namely on French materialists. In our paper, we proceed to an analysis of this comparison and shed light on one of the most influential receptions of Epicurus’s philosophy in modernity. In this perspective, we show their inherent relation and focus more particularly on their modal theories; we thus examine the reasons why- contrary to other cases- the comparison was based less on ethical and mostly on metaphysical matters and we show at what extent it is legitimate.
The Relation of Depression, Stress, Anxiety, and Burnout among Healthcare Workers during the Second Wave of COVID-19 Pandemic in India
Authors: Das Nikhita , Goswami Seujee , Mondal Aritra
Published: September 2023

Objectives

The COVID-19 outbreak has taken a significant toll on frontline workers globally, resulting in psychological stress, burnout, and mental exhaustion. This online-based cross-sectional study aimed to explore the relationship between depression, anxiety, stress, and burnout among healthcare workers (HCWs) providing direct care to COVID-19 patients in the second wave of the COVID-19 pandemic in India.

Material and Methods

The sample size comprised HCWs who met specific inclusion criteria and had completed at least 1 week of posting in COVID-19 units and provided informed consent to participate. Data were collected using semi-structured socio-demographic Proforma, the Depression Anxiety Stress Scale-21 items (DASS-21), and the Copenhagen Burnout Inventory (CBI)-19 items.

Results

Out of 137 participants, 68.6% had moderate and 15.3% had severe depression; 48.9% had moderate and 24.1% had severe anxiety; and 3.6% had extremely severe anxiety. The prevalence of severe and extremely severe stress was 46.7 and 6.6%, respectively. The subscales of the Copenhagen Burnout Inventory, personal and work-related burnout had a positive correlation with all the subscales of the Depression Anxiety Stress Scale-21 items, while client-related burnout only correlated with the stress subscale.

Conclusion

The high prevalence of burnout and other mental health problems in the healthcare workers during the pandemic necessitate the need for the healthcare system to provide psychological support and interventions for physicians working during the pandemic.
Distal Tibial Fractures – Surgical Outcome Following Minimally Invasive Percutaneous Plate Osteosynthesis
Authors: Sajeed Mohamed , Nisha Nasrin , D Sivaraman , T Prabhu
Published: September 2023

Objectives

With preservation of the vascularity of the bone, preservation of the soft tissue envelope and containment of the fracture haematoma, minimally invasive procedures provide fixation in a biologically sound manner. With these in view, this study was conducted to evaluate the technique of surgical management in distal tibial fractures treated by internal fixation with locking compression plate (LCP) and screws through the minimally invasive percutaneous plate osteosynthesis (MIPPO) technique.

Material and Methods

In this cohort study, 21 patients with distal tibial fractures who were admitted to the hospital between November 2014 and August 2016 were tracked for at least 10 weeks and up to 39 weeks. Adults who were fit enough for surgery, both male and female, participated in the study. MIPPO procedures were followed for every case. In this investigation, a total of 21 cases were examined.

Results

86% of cases with proper bone union were able to bear their full weight at or before the 18-week mark. Complete weight bearing was permitted for the final three patients (14%) at or before 39 weeks. Ninety per cent of patients had fracture union rates that were satisfactory to excellent at 23 weeks. Also, delayed unions were noted in three individuals; two cases experienced ankle stiffness, one as a result of prolonged immobilization and the other as a result of an intra-articular fracture. There were no infections or wound breakdowns during this trial.

Conclusion

The MIPPO technique with LCP plates is a good choice when intramedullary nailing is inadequate for metaphyseal and distal tibia shaft fractures. Also, early fracture union is easily accomplished using the MIPPO technique and careful application of these plates.
Xanthogranuloma of the suprasellar region mimicking cystic craniopharyngioma: A case report
Authors: Alghamdi Abdulaziz M. , Alghamdi Abdulkarim M. , Samkari Alaa , Samman Afnan , Lary Ahmed
Published: September 2023

Background:

Xanthogranuloma of the sellar region is an extremely rare benign entity with only case reports and series documented in the literature. We aim to describe in this report a case of a suprasellar xanthogranuloma that was diagnosed initially as a cystic craniopharyngioma.

Case Description:

A 28-year-old woman presented to the clinic with a 2-week history of headaches, blurred vision, nausea, and vomiting. She had no medical or surgical history, no signs of hormonal disturbances, and no family history of brain tumors or endocrine diseases. Her neurological examination was unremarkable except for bitemporal hemianopia on visual field testing. A magnetic resonance imaging of the brain showed a cystic mass in the sellar region that was compressing the optic chiasm with radiological features representing cystic craniopharyngioma. She underwent endoscopic transnasal transsphenoidal surgery to excise the mass, and only subtotal excision was achieved to preserve the pituitary function. The histopathology confirmed the diagnosis of a xanthogranuloma of the sellar region. The postoperative course was unremarkable, and she did not receive any adjuvant therapy. There was no recurrence of the clinical symptoms or the mass during the 18-month follow-up period.

Conclusion:

Although xanthogranuloma is uncommon, it should be included in the differential diagnosis of sellar/suprasellar lesions. Due to its wide range of radiological features that sometimes can mimic other lesions, a definitive diagnosis can only be made postoperatively. Surgical excision is the most accepted treatment with a favorable prognosis and low rates of recurrence.
Hypersensitive Inhibition of Organocatalysts by Halide Salts
Authors: Leino Teppo , Noutsias Dimitris , Helttunen Kaisa , Moilanen Jani , Tarkkonen Eeki , Kalenius Elina , Kiesilä Anniina , Pihko Petri
Published: September 2023

Conformationally flexible tertiary amine—thiourea-urea catalysts for the Mannich reaction between imines and malonate esters are efficiently inhibited by quaternary ammonium halides. NMR titrations, isothermal titration calorimetry and NOE experiments showed that the catalysts bind chloride and bromide ions with relatively high affinities (K = 103–105 M–1 in acetonitrile), and they refold into catalytically inactive conformations upon complexation. At substoichiometric inhibitor:catalyst ratios, the reactions displayed hypersensitivity to the inhibitors, with overall rates that were lower than those expected from simple 1st order kinetics and 1:1 inhibitor:catalyst stoichiometry. The Mannich reactions turned out to be 2nd order in catalyst, and this finding also readily explains the observed hypersensitivity.
Effect of Apical Ligands, Substituents and Oxidation States on the Electronic Structure of Co(III) Corrolates
Authors: Neuman Nicolas
Published: September 2023

Cobalt(III) corroles are the most commonly studied types of metallocorroles, yet the details of their electronic structure, ground spin states and place of redox events are not always straightforward. Corroles are redox active, potentially non-innocent ligands, and it has been found through various experimental and computational techniques, that the innocent or non-innocent behavior is modulated by the apical ligands bound to the cobalt center. In this work, we aim to analyze the effect of corrole substituents and number and type of apical ligands on the electronic structure of cobalt corroles through density functional and wavefunction theories, and to determine the relative energies between closed- and open-shell states. We further perform preliminary analyses on the place of electron abstraction upon oxidation and on the effect of the corrole and apical ligands on the cobalt ligand field splittings. We find that both ligand field and electron-donating or withdrawing effects determine the relative energies of open-shell and closed shell singlet states
Unraveling the Origin of Unusual Shift in the Electroluminescence of 1D CsCu2I3 Light-Emitting Diodes
Authors: Kuruppu Udara M. , Rahman Mohammad A , GANGISHETTY MAHESH K
Published: September 2023

Lead-free low-dimensional copper-based metal halides are promising luminescent materials for broadband LEDs owing to their broad self-trapped exciton (STE) emission. However, recently in 1D CsCu2I3, a discrepancy between their electroluminescence (EL) and photoluminescence (PL) has been observed. As a result, the overall output color from LEDs is significantly different than the anticipated emission. To unveil the origin of this discrepancy, here, we provide comprehensive analyses and show that the shift in the EL is neither caused by any structural/optical interactions between CsCu2I3 and electron transport layers (ETL) nor by the degradation of 1D CsCu2I3. Instead, it depends on the carrier imbalance on CsCu2I3, mainly due to the difference in electron mobility of the ETLs and the electron density on the CsCu2I3 layer. By varying the ETLs, different colored 1D CsCu2I3 LEDs with peaks at 556 nm, 590 nm, and 620 nm are fabricated, and a maximum luminance of over 2000 Cd/m2 is achieved for a 556 nm LED. Further, by limiting the electron mobility and injection to 1D CsCu2I3 using an insulating LiF layer at the CsCu2I3/ETL interface, more red-shifted LEDs are achieved confirming the critical role of electron density on the EL characteristics of 1D CsCu2I3.
MODELS OF STOCK MARKET OPTIMIZATION IN ENGINEERING IN THE SOCIO-ECONOMIC ASPECT
Authors: Кузнецов В.П. , Лаврентьева Е.В.
Published: September 2023

Цель статьи – рассмотреть и проанализировать состояние фондового рынка машиностроения в аспекте воздействий на него рыночного и инвестиционного рисков. Проведенный анализ участников рынка российских акций позволил осуществить сравнение действий основных игроков рынка: инвесторов и спекулянтов. Выявленные и обозначенные в статье действия на примере фондового рынка предприятий автопрома предоставили возможность выделить их цикличность и обозначить основные задачи инвесторов. В исследовании приведен комплекс математических методов и моделей управления финансовыми рисками: метод VAR, модель регрессионного анализа и оптимизационная модель тарификации в страховании. Научная новизна представлена разработанным инновационным базисом и рекомендациями по его использованию для фондового рынка предприятий машиностроения.

The article discusses the management of investment risks Industrial enterprises and investors in the Russian stock market. The analysis of the participants of the Russian stock market was carried out; the comparison of investors and speculators was carried out. The article discusses the trends in the market. An example of a trend is given and an analysis of cycles is carried out. The main tasks of speculators and the main tasks of investors are highlighted. The definition of technical and fundamental analysis is given, the classification of technical analysis is considered. The article calculates the method of investment risk management VAR. Recommendations have been developed to reduce investment risk for investors and speculators.