bluuebunny/crossref_metadata_2025 huggingface dataset:
Musculoskeletal Infection: The Great Mimickers on Imaging
Authors: Klontzas Michail E. , Vassalou Evangelia E. , Spanakis Konstantinos , Alpantaki Kalliopi , Karantanas Apostolos H.
Published: August 2024

A series of conditions can mimic musculoskeletal infections on imaging, complicating their diagnosis and affecting the treatment. Depending on the anatomical location, different conditions can manifest with clinical and imaging findings that mimic infections. Herein we present a wide spectrum of the musculoskeletal disorders of the axial skeleton, long bones, peripheral joints and soft-tissue which may manifest as an infectious process, besides focusing on the potential mimics of osteomyelitis, septic arthritis and infectious spondylodiscitis that are common in clinical practice. We present the typical imaging characteristics of each musculoskeletal infection, followed by mimicking conditions.
Paper-Based Analytical Devices Based on Amino-MOFs (Mil-125, UiO-66 and Mil-101) as Platforms towards Biosensing Applications
Authors: Piguillem Sofía V. , Gomez Germán E. , Tortella Gonzalo R. , Seabra Amedea B. , Regiart Matías D. , Messina Germán A. , Fernández-Baldo Martín A.
Published: August 2024

In this study, we have designed a promising platform based on metal-organic frameworks (MOFs) to develop paper-based analytical devices (PADs) to immobilize biomolecules for application in biosensors. PADs have become increasingly popular in sensing applications in recent years due to their portability, low cost, simplicity, efficiency, fast detection capability, excellent sensitivity, and selectivity. In addition, MOFs are an excellent choice for developing highly sensitive and selective sensors. Their ability to reversibly and reproducibly adsorb and desorb specific molecules allows using these materials as sensors for various applications. They also offer the possibility to modify their structure and properties, making them highly versatile and adaptable to different environments and sensing needs. In this research, we synthesized and characterized three different amino-functionalized MOFs: UiO66-NH2 (Zr), MIL125-NH2 (Ti), and MIL101-NH2 (Fe). These MOFs were used to fabricate PADs capable of sensitive and portable monitoring of alkaline phosphatase (ALP) enzyme activity by laser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significant potential for integration into biosensor PADs, offering key properties that enhance their performance and applicability in analytical chemistry and diagnostics.
Research on the Application of Conjoint Analysis Method in Carbon Tax Pricing for the Sustainable Development Process of China
Authors: Zhang Jiahao , Li Chaolin , Ji Xiangnan , Zhang Li , Chen Yanjun
Published: August 2024

Carbon tax policies (CTP) are globally acknowledged for curbing energy consumption and emissions. Despite global adoption, China's reluctance to embrace a carbon tax, possibly due to effectiveness and public acceptance concerns, is notable. This study employs Choice-Based Conjoint Analysis to gauge Shanghai residents' preferences on four CTP attributes. Among Shanghai's populace, the annual cost of the carbon tax policy ranks highest (48.87%), followed by implementation transparency (24.72%), revenue utilization (16.68%), and policy implementers (9.73%). Notably, Shanghai residents exhibit an average annual willingness to pay of 1435.28 CNY, indicating increased acceptance. Enhanced public awareness of carbon tax policies significantly boosts willingness to pay, augmenting carbon tax revenues and fostering low-carbon technology development. Additionally, transparency improvements in carbon tax policy yield notable increases in willingness to pay, underscoring the link between understanding CTP and its perceived importance. These findings highlight the potential of carbon tax policies in advancing sustainability and transitioning to low-carbon economies.
Identification of Reliable Reference Genes for Use in Gene Expression Studies in Rat Febrile Seizure Model
Authors: Kovalenko Anna A. , Zakharova Maria V. , Schwarz Alexander P. , Zubareva Olga E. , Zaitsev Aleksey V.
Published: August 2024

The study of the pathogenesis of febrile seizures and their consequences frequently necessitates gene expression analysis. The primary methodology employed for such analysis is reverse transcription with quantitative polymerase chain reaction (RT-qPCR). To guarantee the accuracy of data obtained by RT-qPCR, it is crucial to utilize stably expressed reference genes. The objective of this study was to identify the most suitable reference genes for use in the analysis of mRNA production in various brain regions of rats following prolonged neonatal febrile seizures. The expression stability of eight housekeeping genes was evaluated using the online tool RefFinder in the dorsal and ventral hippocampal regions and in the temporal and medial prefrontal cortex of the brain. The Ppia gene exhibited the greatest stability of expression. Conversely, the genes with the least stable expression level are Actb and Ywhaz; thus, it is not recommended to use them for normalization in a febrile seizure model. Additionally, the majority of housekeeping genes demonstrate age-related, region-specific fluctuations. Therefore, it is crucial to employ the appropriate housekeeping genes for each brain structure under investigation when examining the expression dynamics of genes of interest in a febrile seizure model.
Long Term Side Effects of Testicular Cancer and Treatment (Observational Study of Mortality and Morbidity in Testicular Cancer Survivors)
Authors: Khan M Raheel , Kearney Sheehan Patrice , Bazin Ashley , Farooq Abdul Rehman , Leonard Christine , Aleem Umair , Corrigan Lynda , Mc Dermott Ray
Published: August 2024

Purpose: Testicular cancer (TC) is a rare cancer but due to early age at diagnosis and excellent cure rates, there is a big cohort of survivors. Recent studies have highlighted the late side effects of treatments of TC especially cisplatin based chemotherapy. These complications make the survivorship care challenging with detrimental effects on health and prognosis of TC survivors. In this study we provide a snapshot of common late side effects in TCS and a possible care pathway with nurse-led specialised clinic. Methods: We invited TCS in one of the cancer centre in Ireland for a comprehensive screening using questionnaires, examination and blood tests. Further investigations were performed as indicated. Mortality was assessed through retrospective chart reviews. Results: We recruited 78 TCS to participate in study. 3 patients who had died in survivorship phase were assessed through retrospective chart review. Second malignant neoplasms accounted for all three mortalities. Most common conditions in TCS after 5 years of diagnosis were hypertension (40%), dyslipidaemia (55.6%), hypogonadism (~45%) and high body mass index (52%). Majority of underlying conditions were diagnosed during screening in our clinic including two cases of coronary artery disease and one case of transient ischaemic attacks. Chemotherapy and age more than 30 years at the time of TC diagnosis were associated with a higher incidence of the late side effects. Conclusions: TC is a highly curable cancer but survivorship phase is marred by a range of late side effects. As we lack clear guidelines and care pathways for survivorship, this remains a challenge for patients and healthcare workers. A nurse-led, specialised, screening clinic can improve the care and prognosis of TC survivors.
Sleeve Gastrectomy Reduces Body Weight and Food Intake in Diet-Induced Obese Mice with No Alterations in Anorexigenic and Orexigenic Hypothalamic Genes
Authors: Balbo Sandra Lucinei , Soares Gabriela Moreira , Morari Joseane , Felisberto Júnior Antônio Machado , Vettorazzi Jean Franciesco , Bronczek Gabriela Alves , Bonfleur Maria Lúcia , Carneiro Everardo Magalhães , Velloso Licio Augusto , Boschero Antonio Carlos
Published: August 2024

The epidemic of obesity has increased worldwide and is associated with comorbidities as diabetes as cardiovascular disease. Strategies that modulate body weight and improves glycemic metabolism has increased, and the bariatric surgeries as Sleeve Gastrectomy (SG) has been highlighted in obesity treatment. However, the mechanism by which SG reduces body weight and improves glycemic control are unknow. C57BL mice were submitted to a 10 weeks high fat-diet protocol and submitted to SG. Food intake, fed/fasted glycemia and hypothalamic anorexigenic and orexigenic gene expression were evaluated. SG reduces body weight, fasting glycemia, insulinemia and leptinemia in obese mice. Moreover, SG reduces food and total calorie intake with no alterations in the expression of anorexigenic and orexigenic gene expression. These data indicates that SG improves obesity associated alterations, at least in part, by reduction on food intake. This effect is not associated with the classic food intake pathway in hypothalamus, indicating the involvement of supplementary pathways in this process.
The Use of the International Classification of Functioning, Disability and Health for Cancer Rehabilitation Evaluation and Follow-Up: A Structured Proposal
Authors: Ferratto Ana Laura Contim , Cortelini Munique Égle Doná , Almeida Luciana Alexandra Antônia de , Hamamoto Adriana Naomi , Reis Fabiana , Couto Livia Garcia Drago , Souza Luiz Paulo Marques de , Almeida Elisângela Pinto Marinho de , Imamura Marta , Battistella Linamara Rizzo , Brito Christina May Moran de
Published: August 2024

Background/Objectives: The aim of this study is the operationalization of the International Classification of Functioning, Disability and Health in the rehabilitation care performed at the Institute of Cancer of the State of São Paulo through structuring a goal-oriented tool with relevant categories of evaluation and follow-up for cancer outpatients to be applied by physiatrists, physiotherapists, physical educators, occupational therapists, and psychologists. Methods: A qualitative study based on a literature review and a modified Delphi exercise, Estimate-Talk-Estimate (ETE) technique, was performed with the service’s rehabilitation experts. Consensus was obtained after four rounds under the 80% agreement threshold. Results: Forty categories were identified for neuropsychological evaluation and thirty-three for psychoaffective support, with 12 goals. Thirty-five categories with 13 goals were accounted for physiotherapy. Physical educators identified 18 categories, with 7 goals. Occupational therapists selected 54 categories, with 10 goals. A referral for personal factors was established. Functional Assessment of Cancer Therapy-General (FACT-G) was the quality of life tool chosen to be applied. Conclusions: A set of relevant ICF categories was structured, tailored by a clinically meaningful routine of assessment and follow-up of cancer outpatients based on specialists’ clinical practice and scientific literature. It will contribute for analyzable and more specific and quantifiable institutional health data. Its implementation and future discussion may promote the instrument’s refinement for its use in this population.
Efficient Regeneration of Transgenic Rice from Embryogenic Callus via Agrobacterium-Mediated Transformation: A Case Study using GFP and Apple MdFT1 Genes
Authors: Do Van Giap , Kim Seonae , Win Nay Myo , Kwon Soon-Il , Kweon Hunjoong , Yang Sangjin , Park Juhyeon , Do Gyungran , Lee Youngsuk
Published: August 2024

Genetic transformation is a critical tool for gene manipulation and functional analyses in plants, enabling the exploration of key phenotypes and agronomic traits at the genetic level. While dicotyledonous plants offer various tissues for in vitro culture and transformation, monocotyledonous plants, such as rice, have limited options. This study presents an efficient method for genetically transforming rice (Oryza sativa L.) using seed-derived embryogenic calli as explants. Two target genes were utilized to assess regeneration efficiency: green fluorescent protein (eGFP) and the apple FLOWERING LOCUS T (FT)-like gene (MdFT1). Antisense MdFT1 was cloned into a vector controlled by the rice α-amylase 3D (Ramy3D) promoter, while eGFP was fused to Cas9 under the Ubi promoter. These vectors were introduced separately into rice embryogenic calli from two Korean cultivars using Agrobacterium-mediated transformation. Transgenic seedlings were successfully regenerated via hygromycin selection using an in vitro cultivation system. PCR confirmed stable transgene integration in the transgenic calli and their progeny. Fluorescence microscopy revealed eGFP expression, and antisense MdFT1-expressing lines exhibited notable phenotypic changes, including variations in plant height and grain quality. This study demonstrated the effective use of seed-derived embryogenic calli for rice transformation, offering a promising approach for developing transgenic plants in monocot species.
High-Intensity Interval Training (HIIT) program in High-School Physical Education Classes for promoting Fitness in Adolescents: a Randomized Controlled Trial
Authors: Bento André , Raimundo Armando , Carrasco Luis
Published: August 2024

This study aims to investigate whether 16 weeks of High-Intensity Interval Training (HIIT) implemented on Physical Education classes (PEC), can improve physical fitness in high-school adolescents This study was a two-arm randomized controlled trial design with adolescents (15-17 years old). Twelve classes were randomized to either a 16 weeks of HIIT (HIIT-G, n = 106 students) implemented on PEC warm-up or a control group (CG, n = 123 students) of usual PEC warm-up. The HIIT sessions ranged from 14 to 20 all-out bouts intervals, adopting a 2:1 work-to-rest ratio. Post-intervention measures revealed a significant difference between groups in CRF and girls from HIIT-G increased their cardiorespiratory fitness (CRF) with significant difference between female groups and a medium to large effect size. The main findings from this study indicate that brief whole-body HIIT of an extremely low volume, over 16 weeks, can improve CRF in adolescent girls.
Model pedagogi genre untuk mengembangkan keterampilan membaca pemahaman bahasa indonesia di sekolah dasar
Authors: Pitaloka Deby , Istiyati Siti , Yulisetiani Septi
Published: August 2024

This study aims to describe of genre pedagogy learning model on Indonesian language comprehension in elementary school. This research uses literature study method with descriptive analysis technique. In this study, researchers sought data from the number or relevant books on genre pedagogy learning model and reading comprehension in Indonesian language in elementary school. Genre pedagogy is a text-based learning model based on a teaching and learning cycle where teachers provide guidance and interaction to learners before learners create texts independently. In practice, this genre pedagogy is implemented using four stages, namely the initial stage of Building Knowledge, the second stage is modelling, the third stage is joint construction and the last stage, namely independent construction. The application of the genre pedagogy model can indirectly motivate learners to utilize various learning resources around them in reading comprehension, especially when learners build their own understanding.
PENGARUH KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN DENGAN INOVASI PRODUK SEBAGAI VARIABEL MEDIASI
Authors: Desfera Andika Krisnia , Rusno Rusno , Nurdiana Nurfarida Iva
Published: August 2024

Tujuan dari penelitian ini yaitu untuk mengetahui dan menganalisis pengaruh kualitas produk terhadap keputusan pembelian dengan inovasi produk sebagai variabel mediasi pada UD. Tiga Saudara Kabupaten Lumajang. Data dikumpulkan dengan menggunakan teknik penyebaran kuesioner dengan menggunakan skala likert serta sampel yang didapatkan dengan mengambil jumlah responden sebanyak 112 responden yang pernah membeli produk milik UD. Tiga Saudara Kabupaten Lumajang yang didasarkan pada teknik simple randem sampling. Pengujian hipotesis dalam penelitian ini dilakukan dengan menggunakan uji asumsi klasik dan analisis path analysis (analisis jalur). Hasil analisis penelitian ini menunjukan bahwa variabel kualitas produk berpengaruh positif dan signifikan terhadap keputusan pembelian, variabel inovasi produk berpengaruh positif dan signifikan terhadap keputusan pembelian, serta inovasi produk mampu memediasi kualitas produk terhadap keputusan pembelian.
PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL, BUDAYA ORGANISASI DAN KOMITMEN ORGANISASI TERHADAP KEPUASAN KERJA DI DINAS TANAMAN PANGAN HORTIKULTURA DAN PERKEBUNAN KABUPATEN MALANG
Authors: Lalo Anggie Marice Bili , Graha Andi Nu , Wilujeng Sri
Published: August 2024

Dengan penelitian ini, kami berharap dapat mempelajari bagaimana faktor-faktor seperti gaya kepemimpinan transformasional, komitmen organisasi, dan budaya perusahaan memengaruhi kebahagiaan pekerja di tempat kerja. Investigasi saat ini, metodologi penelitian kuantitatif diterapkan. Dengan menggunakan pendekatan Jenuh Sampling yaitu pengambilan sampel seluruh populasi untuk penelitian ini, maka sampel penelitian berjumlah 60 orang ASN Dinas Tanaman Pangan Hortikultura dan Perkebunan Kabupaten Malang. Metodologi analisis data dilakukan dengan menggunakan regresi linier berganda. Komitmen organisasi ternyata berdampak pada Dinas Tanaman Pangan Hortikultura dan Perkebunan Malang, budaya organisasi, dan gaya kepemimpinan transformasional yang pada akhirnya mempengaruhi kepuasan kerja.
PENGARUH’’MOTIVASI’’KERJA’’DAN’’ORGANIZATIONAL CITIZENSHIP”BEHAVIOR”(OCB)”TERHADAP”KINERJA KARYAWAN PADA PT. BERKAH GIAT JAYA KOTA MALANG
Authors: Aprilita Selly Wulan , Sarwoko Endi , Sedyastuti Kristina
Published: August 2024

Penelitian”ini”bertujuan”untuk/mendapatkan informasi mengenai motivasi\kerja/dan organizational citizenship behavior/terhadap/kinerja karyawn\PT.Berkah Giat Jaya Kota Malang. Penelitian ini menggunakan/metode kuantitatif pada instrumen yang dinyatakan valid sehingga\layak digunakan. Responden/yang\diteliti berjumlah 83 karyawan dengan total pertanyaan seba nyak 30\pertanyaan. Peneliti menggunakan data primer dan mengolah data tanggapan responden \menggunakan SPSS. Analisis regresi linier berganda merupakan teknik yang digunakan/dalam\penelitian ini. Hasilipenelitian\menunjukan motivasi kerja dan organizational citizenship behavio\berpengaruh signifikan terhadap kinerja karyawan/PT. Berkah Giat Jaya Kota Malang, motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan/PT. Berkah Giat Jaya Kota Malang, organizational citiznship behavior berpengaruh positif dan signifikan terhadap kinerja kryawan’PT. Berkah Giat Jaya Kota Malang. Bagi peneliti selanjutnya disarankan untuk mengembangkan faktor’lain’di luar faktor’yang sudah diteliti, seperti reward and punishment, budaya organisasi.
Comparison of Relational Database Modeling Performance based on Number of Normalized Entities
Authors: Yunianto Dika Rizky , Yudistira Eka Putra  , Cahya Rahmad
Published: August 2024

The database is the most important part of the development of a software. Management of data storage in the database is very important because the amount of data stored is increasing and varied. Thus requiring increased storage capacity and increased processing time. One form of database used in software is a relational database. Relational database modeling to reduce storage capacity can be circumvented by normalizing the database. From the experimental results, database normalization has an effect on the number of entities. So that the storage capacity and processing time in data processing are also affected by the normalization of the database. The more the number of entities will cause the more time needed in data processing.
Perancangan Aplikasi Sistem Penilaian Kinerja Karyawan Metode TOPSIS Berbasis Website
Authors: Ardiansyah Fatur Rachman
Published: August 2024

Perkembangan teknologi berkembang sejalan dengan berjalannya waktu. Perkembangan teknologi semakin mempengaruhi setiap bagian kehidupan manusia mengikuti perkembangan zaman.  Barbagai macam teknologi yang berkembang pada dunia kerja sangat beragam. Mulai dari sistem yang ringan hingga sistem yang rumit. Dalam lingkup kerja saat ini, banyak aspek yang nyatanya belum tersentuh oleh kemajuan teknologi. Mulai dari bidang rekrutmen, pengembangan, perbaikan, bahkan evaluasi pun juga tidak luput dari sentuhan teknologi. Dalam bidang pengembangan tentu saja berbagai macam model pengembangan baik individu maupun organisasi juga dituntut bisa penggunaan teknologi. Dalam hal perbaikan tentu saja sangat lekat kaitannya dengan penggunaan teknologi. Sedangkan penelitian ini nantinya akan berfokus pada bidang evaluasi kerja yang mana nyatanya juga tersentuh oleh teknologi. Pada PT Sanjayatama Lestari, penilaian karyawan masih menggunakan cara manual dengan melakukan penilaian oleh supervisor dilapangan. Setelah itu supervisor akan ditanyai secara lisan dan dimasukkan pada data berupa catatan atau pada file aplikasi pengolah kata maupun angka. Penilaian yang disampaikan pada perusahaan dimana penilaian bisa saja bersifat objektif dan tidak transparan. Nantinya fokus masalah yang diambil dalam perancangan ini nantinya adalah merancang sistem penunjang keputusan untuk penilaian karyawan pada karyawan PT. Sanjayatama Lestari Surabaya. Metode yang digunakan untuk membuat aplikasi menggunakan metode waterfall. Untuk memudahkan pengguna dan menyesuaikan dengan perangkat maka digunakan bahasa pemrograman berbasis web. Dengan adanya rancangan aplikasi ini diharapkan akan memudahkan pengguna dan memiliki data yang valid serta menghindarkan transparansi dalam penilaian karyawan.
BOARD STRUCTURE AND ISLAMIC BANK STABILITY: A STANDALONE RISK COMMITTEE MODERATING EFFECT
Authors: Umar Umar Habibu , Abduh Muhamad , Besar Mohd Hairul Azrin , Kurawa Junaidu Muhammad
Published: August 2024

This study investigates the impact of board attributes on the stability of Islamic banks and whether the presence a standalone risk management committee (SARC) moderates their relation.  Applying the feasible generalized least squares (FGLS) regression as well as the two-step system generalized method of moments (GMM) estimator for robustness to a panel sample of 43 Islamic banks across 15 countries over eleven years from 2010 to 2020, we document evidence suggesting that board meetings, board gender diversity and foreign directors do not influence the stability of Islamic banks. Conversely, board members holding doctorate degrees (PhDs) significantly and negatively affect the stability of Islamic banks.  In addition, the presence of SARC significantly improves the stability of Islamic banks.  The study further finds that SARC partially and positively moderates the effects of board members with PhDs and foreign directors on the stability of Islamic banks.
HALAL AWARENESS: IMPACT ON PURCHASING HALAL MEDICINES UNVEILED
Authors: Al Maslul Syaifullah , Priantina Anita
Published: August 2024

Indonesia offers significant opportunities for the halal sector thanks to its predominantly Muslim population. However, there is a notable lack of certified halal medicines, which is surprising given the crucial role that medicines play in human life. This study aims to investigate how awareness of halal practises influences Muslim consumers' intention to purchase halal medicines, with a particular focus on the Jabodetabek region. The study is based on a total of 150 respondents and employs a partial least squares structural equation modelling (PLS-SEM). From the analysis, it is found that awareness of halal products has a significant influence on the intention to purchase halal medicines. In addition, both subjective norms and perceived behavioural control are identified as significant factors influencing the intention to purchase halal medicines. However, it is worth noting that attitude does not have a statistically significant influence on the intention to purchase halal medicines. This result may be attributed to the limited availability of halal-certified medicines, which influences the attitude of individuals in the decision-making process.
Improving Student Learning Outcomes Through the Flipped-Project Based Learning Model: An Experimental Study
Authors: Bashith Abdul , Amin Saiful , Mindarti Sri , Kurniawan Muchammad Akbar , Dewi Sari , Mkumbachi Ramadhani Lausi
Published: August 2024

This study aims to determine the effectiveness of the Flipped-Project-based Learning model on student learning outcomes. This type of quasi-experimental research uses a control group pretest-posttest design that is applied to class XI IPS SMA Negeri 8 Malang, Indonesia (social sciences program at State Senior High School) academic years 2023-2024. The instrument used is an essay test of 5 questions on International Economic Cooperation material that has been tested for validity and reliability. Data analysis used tests of normality, homogeneity, and independent sample t-test. The result of the study showed that the Flipped-Project Based Learning model was effective in improving students' student learning outcomes in Economics Lessons. Recommendations for further research, it is necessary to develop a project-based model in a blended or hybrid model by utilising digital learning or e-learning platforms.
SORCHIC: Second Order Reversible Cellular Automata based Hybrid Image Cipher for IoT applications
Authors: Rao Vijaya Bhaskara , Rawat Umashankar , Roy Satyabrata , Lal Chhagan
Published: August 2024

In the rapidly evolving digital world, ensuring secure data transmission, especially in image data pivotal to modern communication, remains critical. The Internet of Things (IoT) amplifies the need for encryption systems that blend robust security with efficiency. However, current cryptosystems often compromise one for the other. To address this, emerging algorithmic techniques aim to strike a balance. Among these, First Order Cellular Automata (FOCA) show promise for image encryption, aligning seamlessly with image processing intricacies while maintaining lower implementation complexity. This paper introduces SORCHIC, a novel hybrid encryption algorithm designed specifically for IoT applications encrypting multichannel images. Leveraging Second-Order Cellular Automata (SOCA) and Chaotic Maps, SORCHIC undergoes comprehensive exploration within this work. Detailed insights into its inner workings are provided, followed by a rigorous experimental analysis comparing it to existing encryption methods. The results underscore SORCHIC’s resilience against diverse cryptanalysis attacks and highlight its superior efficiency compared to established techniques. This study contributes to advancing encryption methods, particularly in IoT, by presenting a robust, efficient, and secure approach tailored for image data transmission.
Strain-Dependent Charge Trapping and Its Impact on the Operational Stability of Polymer Field-Effect Transistors
Authors: Cho Kilwon , Park Sangsik , Kim Seung Hyun , Lee Hansol
Published: August 2024

Despite recent dramatic improvements in the electronic characteristics of stretchable organic field-effect transistors (FETs), their low operational stability remains a bottleneck for their use in practical applications. Here, the operational stability, especially the bias-stress stability, of semiconducting polymer-based FETs under various tensile strains is investigated. Analyses on the structure of stretched semiconducting polymer films and spectroscopic quantification of trapped charges within them reveal the major cause of the strain-dependent bias-stress instability of the FETs. Devices with larger strains exhibit lower stability than those with smaller strains because of the increased water content, which is accompanied by the formation of cracks and nanoscale cavities in the semiconducting polymer film as results of the applied strain. The strain-dependence of bias-stress stability of stretchable OFETs can be eliminated by passivating the devices to avoid penetration of water molecules. This work provides new insights for the development of bias-stable stretchable OFETs.
Elastoplastic analysis of surrounding rock in weakly cemented soft rock roadways and its support practice
Authors: Zhang Jihua , Rui Qiao , Li Xinwei , Yang Yushun , Wang Ge , Chen Jiarui , Shen Wei , Wang Chengwu , Liu Weili
Published: August 2024

The effects of rock softening and shear dilation in the plastic zone are considered to examine the stability of surrounding rock in deep, weakly cemented soft rock roadways. An elastic-soft fracture mechanical model of the surrounding rock is developed, from which the analytical solutions for the stress and displacement fields are derived, providing expressions for the radius of the plastic zone. This analysis assesses the impact of cohesion, internal friction angle, and support force on the stress field, displacement field, and plastic zone radius. The results indicated that the elastic-plastic mechanical model, which considers the softening and shear dilation effects, more accurately represents the deformation characteristics of the roadway's surrounding rock across the zones of elasticity, softness, and fragmentation. As initial cohesion and internal friction angle increase, the surrounding rock's load resistance is enhanced, delaying the emergence and expansion of plastic zones. The elastic-plastic interface moves toward the excavation surface, causing a gradual increase in the circumferential stress at the interface. With increasing cohesion and internal friction angle, the radius of the plastic zone exhibits a non-linear decrease, with the plastic fracture zone diminishing first. The influence of cohesion and internal friction angle on the various zones of surrounding rock is ranked as follows: radius of plastic fracture zone > plastic softening zone > elastic zone. A joint support scheme, incorporating "anchor net and cable injection" with grouting as the core component, is proposed for a project overview of weakly cemented soft rock roadways in the western mining area. This scheme achieves positive outcomes and enhances the safety of roadway construction.
Coulomb Stress Characteristics and Fault Slip Distribution of the 2023 Mw 6.1 Earthquake in Jishishan County (Gansu, China) Based on InSAR Observations
Authors: yu shuyuan , Zhang Shubi , Li Zhejun , Luo Jiaji , Yang Yuanyuan , Ding Juan
Published: August 2024

On December 18, 2024, a Mw 6.1 earthquake occurred in Jishishan County, Linxia Prefecture, Gansu Province. This earthquake is the largest recorded since the establishment of seismic observations on the Laji Mountain fault zone along the northeastern edge of the Tibetan Plateau. This study utilizes Sentinel-1A satellite data to obtain the coseismic deformation field from ascending and descending tracks of the 2023 Jishishan earthquake, using this information to constrain the inversion of the earthquake's fault kinematic parameters and fault slip distribution characteristics. Finally, integrating the characteristics of Coulomb stress changes with regional tectonic background research results, we assess the seismic hazard of the region. The study indicates that the deformation field generated by this earthquake is oriented predominantly in the NNW direction, with the coseismic deformation from both ascending and descending tracks mostly exhibiting uplift. The maximum line-of-sight (LOS) displacement for the ascending track is approximately 6 cm, while for the descending track it is about 6.7 cm. The results of slip testing on the coseismic fault suggest that both east-dipping and west-dipping fault geometric models can adequately explain the parameters of the fault that caused this earthquake. Based on aftershock relocation and comprehensive analysis of the regional tectonic background, the study concludes that the rupture likely occurred on a northeast-dipping fault, potentially a concealed reverse fault with an NNW orientation located along the southern margin of Laji Mountain. Calculations of static Coulomb stress changes indicate that the occurrence of the 2023 Jishishan earthquake has increased the risk of future seismic events along segments of the NWW-oriented southern and northern margins of the Laji Mountain fault, as well as to the east of the epicenter along the Xiqinling northern fault and the Daotanghe-Linxia fault.
T Cell Exhaustion Methylation Signature Drives Differential Immune Responses in Glioblastoma
Authors: Chen Feng , Qian Wen-Bo , Chen Zhen-Hua , Qian Jun , Luo Chun
Published: August 2024

Background Methylation-related signatures play crucial roles in tumorigenesis and progression. However, their roles in the immune response in primary glioblastoma (GBM) remains unclear.Methods We analyzed the differential expression of specific members of T cell exhaustion-related pathways in GBM from the perspective of T cell exhaustion. We further screened for significantly negatively correlated methylation sites as candidate methylation markers for T cell exhaustion. Using consensus clustering, we divided the samples into two categories with significant differences in overall survival (OS). We then performed univariate and multivariate Cox regression analyses to construct the T Cell Exhaustion Methylation (TEXM) signature. Finally, we confirmed that this signature served as an independent prognostic factor, and further characterized it in terms of drug resistance and immunotherapy.Results We identified 95 significantly differentially expressed T cell exhaustion-related genes and 51 methylation markers associated with T cell exhaustion. The cancer samples were classified according to methylation site markers, thus indicating two subtypes with significant differences in OS: subtype A and subtype B. Tumor scores, stromal scores, tumor purity, and ESTIMATE scores all showed significant differences between subtypes (P < 0.05). Univariate Cox regression analysis identified five methylation sites significantly associated with OS, and multivariate Cox regression analysis was used to construct the TEXM signature model by using these five methylation sites. Survival analysis, based on calculating the TEXM signature scores of tumor samples and using the median score to divide them into high and low score groups, revealed significant OS differences between high score group and low score group in the validation set. However, comparison of the TEXM signature with clinical TEXM Additionally, drug sensitivity significantly differed between the high and low TEXM signature score groups, with the high score group showing higher drug resistance and poorer prognosis. The tumor immune state, as predicted with TIP, revealed significant differences in antitumor immune scores between the high and low TEXM signature score groups. Finally, we identified 43 significantly differentially regulated metabolism-associated biological processes.Conclusion The epigenetic methylation-related TEXM signature plays a key role in driving differential immune responses in GBM.
Self-deception, Psychological Capital and Depression in Normal University Students: A Cross-lagged Analysis
Authors: Chen Yuxia , Wahab Rozita Binti , Jaladin Rafidah Binti Aga Mohd
Published: August 2024

University students are particularly vulnerable to depression. This study examines the correlation and causation between self-deception, psychological capital, and depression in a sample of students from Chinese normal university and assumes that self-deception, like psychological capital, is a positive psychology variable to supply rational interventions for the precaution of potential depressive normal university students. A 3-month follow-up mental health study was conducted on 260 Chinese normal university students, using Self-Deceptive Enhancement scale, Center of Epidemiological Studies Depression Scale and Positive Psychological capital Questionnaire. The Cross-lagged panel Model was employed to test the causal relationship between self-deception, psychological capital, and depression. The prevalence of depression among the average college student is as high as 35.0%. The correlation analysis showed that self-deception was positively correlated with psychological capital and negatively correlated with depression, and psychological capital was negatively correlated with depression. The cross-lagged analyses revealed that self-deception could negatively predict depression (β = -0.16, p < 0.01); Psychological capital could negatively predict depression (β= -0.16, p < 0.01); Self-deception could positively predict psychological capital (β = 0.23, p < 0.001) and the reciprocal effect (β = 0.13, p < 0.05) was also observed. The existence of a causal relationship between self-deception, psychological capital and depression, which support the cognitive bias orientation of self-deception and the risk compensation model of psychological capital, and provides a theoretical basis for designing easy-to-administer interventions to alleviate students' depressive symptoms in the classroom.
Resin anchoring reinforcement for multi-stage reaming of a cable bolt in a soft-rock roadway
Authors: Zhao Hongrui
Published: August 2024

In cable bolt reaming and anchoring of a soft-rock roadway tunnel, the cable bolt and its stirring end are in direct contact with the wall of the drilling hole, which can easily damage the structure of the drilling hole. The cable bolt cannot effectively break and stir the resin cartridge in the reaming area. The anchoring force of the cable bolt is low and the deformation of the surrounding rock is large. The characteristics of cable bolt reaming and anchoring in a soft-rock roadway are analyzed systematically. The influence of the cable bolt on the reaming and anchoring performance is calculated and analyzed in terms of cable bolt stirring, anchoring solid strength, pull-out force, cable bolt concentricity, and the influence of the drilling hole wall. A multi-stage reaming and anchoring reinforcement (MRAR) is developed, and the mechanism through which the MRAR strengthens the reaming and anchoring of a cable bolt is analyzed theoretically. Through numerical simulation and laboratory and field experiments, the working performance of the MRAR is verified comprehensively. The results show that the MRAR greatly improves the dynamic stirring action of the cable bolt, compactness and strength of the anchoring solid, drilling performance, concentricity, pull-out force, and pretension. It can ensure to the maximum extent that all the resin cartridge in the reaming area is stirred, reacted, and firmly bonded with the hole wall. It greatly improves the reaming and anchoring and roof deformation control of the cable bolt in the soft-rock roadway. This technology has practical significance for improving the reaming and anchoring of a cable bolt and the bearing capacity of the surrounding rock in a soft-rock roadway tunnel.
Impact of growing media on yield, biochemical, and physiological characteristics of Rheum rhabarbarum L
Authors: Daryadar Mahsa , Matevosyan Artur , Roosta Hamid Reza , Ghorbanpour Mansour , Ghahramanyan Aristakes , Stepanyan Anjelika , Tadevosyan Anna
Published: August 2024

Rhubarb (Rheum rhabarbarum L.) is a popular springtime vegetable known for its vibrant red stalks and tart flavor. This study explores the intriguing biochemical profile of rhubarb and highlights its potential health benefits. Hydroponic systems (volcanic slag and volcanic slag with gravel significantly increased rhubarb yield (both fresh and dry weight) by 2.6-6.0 times compared to traditional soil, especially in June and July. Rhubarb grown hydroponically also produced 1.6-1.8 times more petioles per plant, each with 1.6 times the fresh weight and 1.1 times the dry weight of soil-grown petioles. Compared to soil, hydroponics significantly increased the levels of extractive substances (1.2-3.2 times), flavonoids (1.4-3.7 times), and phenols (1.2-4.0 times). The research evaluated antioxidant activity, with hydroponically grown rhubarb demonstrating superior performance, particularly in the volcanic slag + gravel plants, which exhibited the strongest antioxidant activity. In contrast, the soil-grown plants displayed the lowest antioxidant activity. According to the FRAP analysis, 1 gram of plant dry mass recovered more iron in the soil-grown variant, followed by the volcanic slag variant. These findings suggest that hydroponic systems, especially those using the volcanic slag substrate, hold promise for cultivating rhubarb enriched with health-promoting compounds in the Ararat Valley.
Modulating cancer stem cell characteristics in CD133+ melanoma cells through HIF1α, KLF4, and SHH silencing
Authors: Aktug Huseyin , Ozdil Berrin , Avci Cigir Biray , Kocaturk Duygu Calik , Gorgulu Volkan , Uysal Aysegul , Guler Gunnur , Yavasoglu Nefise Ulku Karabay
Published: August 2024

Malignant melanoma, an aggressive skin cancer derived from melanocytes, contains a subpopulation known as cancer stem cells (CSCs), with distinct self-renewal and differentiation abilities, setting them apart from non-cancer stem cells (NCSCs). This study aims to examine how CSCs respond to the suppression of their stem cell characteristics through targeted gene silencing of HIF1α, KLF4, and SHH within the context of the extracellular matrix, with a particular focus on Matrigel. Silencing targeted genes individually induced distinct changes in CSCs behavior, revealing novel therapeutic targets through analysis of gene expression, protein levels, and cell cycle dynamics. A comparison between melanoma CSCs and NCSCs revealed significant shifts in SHH signaling, epigenetic markers, differentiation, migration, and vascularization genes. Specifically, CSCs exhibited elevated levels of SHH, Gli1, and HDAC9, while NCSCs showed increased expression of Mif. Our findings highlight the emergence of a unique cellular phenotype following gene silencing, distinct from both CSCs and NCSCs. Diverse signaling pathways underlie this phenomenon, offering valuable insights for development of melanoma therapies.
Dementia special care units in nursing homes: a revised program theory resulting from a theory-driven evaluation
Authors: Adlbrecht Laura , Wallner Martin , Bartholomeyczik Sabine , Mayer Hanna
Published: August 2024

Background: People with dementia often receive care in dementia special care units of nursing homes. The concept of these units vary considerably. Knowledge about the effects and mechanisms of action of dementia special care units is limited. The aim of the study was to evaluate a specific care concept of a dementia special care unit in long-term care. In this paper, we present the results of the evaluation study in the form of a revised program theory. The aim was to describe the components of the care concept, its context as well as its mechanisms of impact and outcomes for persons with dementia and the nursing staff members.
Methods: We conducted a theory-driven evaluation resulting in a revised program theory. The revision was based on an initial program theory and the findings of the outcome/process evaluation. The primarily data-driven revision is enriched by theory and further literature. Data analysis followed a two-step process: evaluation of the original program theory and construction of the revised program theory, consisting of an action and a change model.
Results: The action model describes interventions, context, target groups and implementers. The change model details how the program generates outcomes. Structural, organizational and educational elements promote a shared person-centered understanding of care among nurses. A unified understanding of care favors engagement in meaningful activities and social interactions. It also supports early interventions addressing challenging behavior. Mutually reinforcing interventions create positive experiences and maintain the residents’ personhood. The success of the program is largely based on a workplace culture and a leadership style facilitating person-centered ways of working.
Conclusion: The revised program theory highlights the positive effects of the dementia special care unit care concept on staff and residents. It provides starting points for future practice development. Considering the interdependence of interventions, increased promotion of meaningful activities and social interactions seem advisable. Future research should explore whether the mechanisms of action developed for a specific care concept are transferable to a broader program theory for specialized dementia care.
Trial registration: DRKS00011513
Optimized Enhanced Energy Absorption in Polymer Nanocomposites Reinforced with Nano-Clay, Nano-Silica, and Diethylenetriamine
Authors: Taghipoor Hossein , Ghiaskar Ahmad
Published: August 2024

In today's world, where various industries face ever-increasing developments, improving people's lives and preserving their property and lives are important issues in industrial production. One of the most unpleasant events in life is a collision while using the vehicle. Therefore, in recent decades, the high importance of this issue has attracted the attention of many researchers. The present study investigates the energy absorption of polymer nanocomposites with cylindrical and conical structures with different percentages of clay and silica nanoparticles to determine the various effects of nanomaterials and the effect of structure geometry on energy absorption under quasi-static tests. The design of this experiment was done using Design Expert software and the Box-Benken method. The range of changes of nanomaterials is (0-0.4) percent, and diethylenetriamine material with weight percent (1,3,5) has also been used. The results indicate that with the increase of nanomaterial in this range, the energy absorbed by adding nano silica up to the central point, i.e., 0.2%, we have witnessed an increase in energy absorption, and after that, its intensity has decreased. For the nano clay material, a significant increase of up to 0.4% has been observed in this range, and its trend continues with the previous intensity after the central point. However, in diethylenetriamine material, the highest energy absorption at the central point was 0.2%, after which a downward trend was observed. Also, in the investigation of the geometry of the structure, it was found that cone-shaped structures have higher energy absorption.
Post-COVID Educational Leadership: Emerging Models and Styles for a New Era
Authors: Khawaja Sarwar , Karimi Hengameh
Published: August 2024

A compelling vision, goals to go along with it, and a suitable plan for implementation, observation, and review are all necessary components of modern educational leadership, which is widely regarded as essential for boosting an institution's effectiveness and acting as a catalyst for change and innovative strategy. The COVID-19 pandemic has caused disruptions to the delivery of educational services, highlighting weaknesses in the leadership theory behind schools and universities. The majority of institutes' adoption of suitable crisis management strategies to swiftly adapt to a new reality and effectively address upcoming difficulties at both the administrative and instructional levels was mostly responsible for these failures. Despite the idea of crisis management having been successfully applied in various types of crises and extensively developed theoretically, there is a notable lack of empirical research in this area, indicating that the field of educational leadership has not given it consistent attention. This study bridges the research gap by employing the PRISMA methodology to build a systematic review of scholarly articles published during 2019 and 2022. Following the unstable leader, the paper discusses the challenges faced, the crisis management strategies employed, and the personality attributes most commonly associated with effective crisis leadership during the COVID-19 time frame.