bluuebunny/crossref_metadata_2025 huggingface dataset:
PROLISEAN
Authors: Hourany Edy , Habib Bachir , Fountaine Camille , Makhoul Abdallah , Piranda Benoit , Bourgeois Julien
Published: January 2021

The vision for programmable matter is to create a material that can be reprogrammed to have different shapes and to change its physical properties on demand. They are autonomous systems composed of a huge number of independent connected elements called particles. The connections to one another form the overall shape of the system. These particles are capable of interacting with each other and take decisions based on their environment. Beyond sensing, processing, and communication capabilities, programmable matter includes actuation and motion capabilities. It could be deployed in different domains and will constitute an intelligent component of the IoT. A lot of applications can derive from this technology, such as medical or industrial applications. However, just like any other technology, security is a huge concern. Given its distributed architecture and its processing limitations, programmable matter cannot handle the traditional security protocols and encryption algorithms. This article proposes a new security protocol optimized and dedicated for IoT programmable matter. This protocol is based on lightweight cryptography and uses the same encryption protocol as a hashing function while keeping the distributed architecture in mind. The analysis and simulation results show the efficiency of the proposed method and that a supercomputer will need about 5.93 × 10
25
years to decrypt the message.
Experience
Authors: Fazzolari Michela , Buccafurri Francesco , Lax Gianluca , Petrocchi Marinella
Published: January 2021

Over the past few years, online reviews have become very important, since they can influence the purchase decision of consumers and the reputation of businesses. Therefore, the practice of writing fake reviews can have severe consequences on customers and service providers. Various approaches have been proposed for detecting opinion spam in online reviews, especially based on supervised classifiers. In this contribution, we start from a set of effective features used for classifying opinion spam and we re-engineered them by considering the Cumulative Relative Frequency Distribution of each feature. By an experimental evaluation carried out on real data from Yelp.com, we show that the use of the distributional features is able to improve the performances of classifiers.
Machine Learning for Statistical Modeling
Authors: Roy Urmimala , Pramanik Tanmoy , Roy Subhendu , Chatterjee Avhishek , Register Leonard F. , Banerjee Sanjay K.
Published: January 2021

We propose a methodology to perform process variation-aware device and circuit design using fully physics-based simulations within limited computational resources, without developing a compact model. Machine learning (ML), specifically a support vector regression (SVR) model, has been used. The SVR model has been trained using a dataset of devices simulated a priori, and the accuracy of prediction by the trained SVR model has been demonstrated. To produce a switching time distribution from the trained ML model, we only had to generate the dataset to train and validate the model, which needed ∼500 hours of computation. On the other hand, if 10
6
samples were to be simulated using the same computation resources to generate a switching time distribution from micromagnetic simulations, it would have taken ∼250 days. Spin-transfer-torque random access memory (STTRAM) has been used to demonstrate the method. However, different physical systems may be considered, different ML models can be used for different physical systems and/or different device parameter sets, and similar ends could be achieved by training the ML model using measured device data.
Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG
Authors: Wilson Hannah E. , Stanton David A. , Rellick Stephanie , Geldenhuys Werner , Pistilli Emidio E.
Published: January 2021

The peroxisome proliferator-activated receptors (PPARs) have been previously implicated in the pathophysiology of skeletal muscle dysfunction in women with breast cancer (BC) and animal models of BC. This study investigated alterations induced in skeletal muscle by BC-derived factors in an in vitro conditioned media (CM) system and tested the hypothesis that BC cells secrete a factor that represses PPAR-γ (PPARG) expression and its transcriptional activity, leading to downregulation of PPARG target genes involved in mitochondrial function and other metabolic pathways. We found that BC-derived factors repress PPAR-mediated transcriptional activity without altering protein expression of PPARG. Furthermore, we show that BC-derived factors induce significant alterations in skeletal muscle mitochondrial function and lipid accumulation, which are rescued with exogenous expression of PPARG. The PPARG agonist drug rosiglitazone was able to rescue BC-induced lipid accumulation but did not rescue effects of BC-derived factors on PPAR-mediated transcription or mitochondrial function. These data suggest that BC-derived factors alter lipid accumulation and mitochondrial function via different mechanisms that are both related to PPARG signaling, with mitochondrial dysfunction likely being altered via repression of PPAR-mediated transcription, and lipid accumulation being altered via transcription-independent functions of PPARG.
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling
Authors: Li Shao-Wei , Takahara Terumi , Que Weitao , Fujino Masayuki , Guo Wen-Zhi , Hirano Shin-Ichi , Ye Li-Ping , Li Xiao-Kang
Published: January 2021

The mRNA expression of inflammatory cytokines in the HRW group was lower than in the CSAA group. HRW reversed hepatocyte apoptosis as well as hepatic inflammation and fibrosis in NASH specimens. Molecular hydrogen inhibits LPS-induced inflammation via an HO-1/IL-10-independent pathway. HRW improved hepatic steatosis in the CSAA + HRW group. Sirt1 induction by molecular hydrogen via the HO-1/AMPK/PPARα/PPARγ pathway suppresses palmitate-mediated abnormal fat metabolism.
The RNA-binding protein Quaking regulates multiciliated and basal cell abundance in the developing lung
Authors: Ameis Dustin , Liu Franklin , Kirby Eimear , Patel Daywin , Keijzer Richard
Published: January 2021

RNA-binding proteins (RBPs) form complexes with RNA, changing how the RNA is processed and thereby regulating gene expression. RBPs are important sources of gene regulation during organogenesis, including the development of lungs. The RBP called Quaking (QK) is critical for embryogenesis, yet it has not been studied in the developing lung. Here, we show that QK is widely expressed during rat lung development and into adulthood. The QK isoforms QK5 and QK7 colocalize to the nuclei of nearly all lung cells. QK6 is present in the nuclei and cytoplasm of mesenchymal cells and is only present in the epithelium during branching morphogenesis. QK knockdown in embryonic lung explants caused a greater number of multiciliated cells to appear in the airways, at the expense of basal cells. The mRNA of multiciliated cell genes and the abundance of FOXJ1/SOX2+ cells increased after knockdown, whereas P63/SOX2+ cells decreased. The cytokine IL-6, a known regulator of multiciliated cell differentiation, had increased mRNA levels after QK knockdown, although protein levels remained unchanged. Further studies are necessary to confirm whether QK acts as a blocker for the IL-6-induced differentiation of basal cells into multiciliated cells, and a conditional QK knockout would likely lead to additional discoveries on QK’s role during lung development.
Variability in tracheal mucociliary transport is not controlled by beating cilia in lambs in vivo during ventilation with humidified and nonhumidified air
Authors: Kelly S. J. , Brodecky V. , Skuza E. M. , Berger P. J. , Tatkov S.
Published: January 2021

Mucociliary transport in the respiratory epithelium depends on beating of cilia to move a mucus layer containing trapped inhaled particles toward the mouth. Little is known about the relationship between cilia beat frequency (CBF) and mucus transport velocity (MTV) in vivo under normal physiological conditions and when inspired air is dry or not fully humidified. This study was designed to use video-microscopy to simultaneously measure CBF and MTV in the tracheal epithelium through an implanted optical window in mechanically ventilated lambs. The inspired air in 6 animals was heated to body temperature and fully saturated with water for 4 hours as a baseline. In another series of experiments, 5 lambs were ventilated with air at different temperatures and humidities and the mucosal surface temperature was monitored with infrared macro-imaging. In the baseline experiments, during ventilation with fully humidified air at body temperature, CBF remained constant, mean 13.9 ± 1.6 Hz but MTV varied considerably between 0.1 and 26.1 mm/min with mean 11.0 ± 3.9 mm/min, resulting in a maximum mucus displacement of 34.2 µm/cilia beat. Fully humidified air at body temperature prevented fluctuations in the surface temperature during breathing indicating a thermodynamic balance in the airways. When lambs were ventilated with dryer air, the mucosal surface temperature and MTV dropped without a significant change in CBF. When inspired air was dry, mainly latent heat (92%) was transferred to air in the trachea, reducing the surface temperature by 5 °C. Reduced humidity of the inspired air lowered the surface temperature and reduced MTV in the epithelium during ventilation.
UCHL1, a deubiquitinating enzyme, regulates lung endothelial cell permeability in vitro and in vivo
Authors: Mitra Sumegha , Epshtein Yulia , Sammani Saad , Quijada Hector , Chen Weiguo , Bandela Mounica , Desai Ankit A. , Garcia Joe G.N. , Jacobson Jeffrey R.
Published: January 2021

Increasing evidence suggests an important role for deubiquitinating enzymes (DUBs) in modulating a variety of biological functions and diseases. We previously identified the upregulation of the DUB ubiquitin carboxyl terminal hydrolase 1 (UCHL1) in murine ventilator-induced lung injury (VILI). However, the role of UCHL1 in modulating vascular permeability, a cardinal feature of acute lung injury (ALI) in general, remains unclear. We investigated the role of UCHL1 in pulmonary endothelial cell (EC) barrier function in vitro and in vivo and examined the effects of UCHL1 on VE-cadherin and claudin-5 regulation, important adherens and tight junctional components, respectively. Measurements of transendothelial electrical resistance confirmed decreased barrier enhancement induced by hepatocyte growth factor (HGF) and increased thrombin-induced permeability in both UCHL1-silenced ECs and in ECs pretreated with LDN-57444 (LDN), a pharmacological UCHL1 inhibitor. In addition, UCHL1 knockdown (siRNA) was associated with decreased expression of VE-cadherin and claudin-5, whereas silencing of the transcription factor FoxO1 restored claudin-5 levels. Finally, UCHL1 inhibition in vivo via LDN was associated with increased VILI in a murine model. These findings support a prominent functional role of UCHL1 in regulating lung vascular permeability via alterations in adherens and tight junctions and implicate UCHL1 as an important mediator of ALI.
Mineralocorticoid receptors in the pathogenesis of insulin resistance and related disorders: from basic studies to clinical disease
Authors: Jia Guanghong , Lockette Warren , Sowers James R.
Published: January 2021

Aldosterone is a steroid hormone that regulates blood pressure and cardiovascular function by acting on renal and vascular mineralocorticoid receptors (MRs) to promote sodium retention and modulate endothelial function. Indeed, MRs are expressed in endothelial cells, vascular smooth muscle cells, adipocytes, immune cells, skeletal muscle cells, and cardiomyocytes. Excessive aldosterone and associated MR activation impair insulin secretion, insulin metabolic signaling to promote development of diabetes, and the related cardiometabolic syndrome. These adverse effects of aldosterone are mediated, in part, via increased inflammation, oxidative stress, dyslipidemia, and ectopic fat deposition. Therefore, inhibition of MR activation may have a beneficial effect in prevention of impaired insulin metabolic signaling, type 2 diabetes, and cardiometabolic disorders. This review highlights findings from the recent surge in research regarding MR-related cardiometabolic disorders as well as our contemporary understanding of the detrimental effects of excess MR activation on insulin metabolic signaling.
Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes
Authors: Segar Jeffrey L. , Grobe Connie C. , Balapattabi Kirthikaa , Ritter McKenzie L. , Reho John J. , Grobe Justin L.
Published: January 2021

Postnatal growth failure is a common morbidity for preterm infants and is associated with adverse neurodevelopmental outcomes. Although sodium (Na) deficiency early in life impairs somatic growth, its impact on neurocognitive functions has not been extensively studied. We hypothesized that Na deficiency during early life is sufficient to cause growth failure and program neurobehavioral impairments in later life. C57BL/6J mice were placed on low- (0.4), normal- (1.5), or high- (3 g/kg) Na chow at weaning ( PD22) and continued on the diet for 3 wk (to PD40). Body composition and fluid distribution were determined serially by time-domain NMR and bioimpedance spectroscopy, and anxiety, learning, and memory were assessed using the elevated plus maze and Morris water maze paradigms in later adulthood ( PD63– PD69). During the diet intervention, body mass gains were suppressed in the low- compared with normal- and high-Na groups despite similar caloric uptake rates across groups. Fat mass was reduced in males but not in females fed low-Na diet. Fat-free mass and hydration were significantly reduced in both males and females fed the low-Na diet, although rapidly corrected after return to normal diet. Measures of anxiety-like behavior and learning in adulthood were not affected by diet in either sex, yet memory performance was modified by a complex interaction between sex and early life Na intake. These data support the concepts that Na deficiency impairs growth and that the amount of Na intake which supports optimal somatic growth during early life may be insufficient to fully support neurocognitive development.
Effects of salt intake on sympathetic neural and pressor responses to cold pressor test in premenopausal women with a history of normal pregnancy
Authors: Takeda Ryosuke , Stickford Abigail S. L. , Best Stuart A. , Yoo Jeung-Ki , Liu Yu-Lun , Fu Qi
Published: January 2021

Excessive salt intake is considered a risk factor for the development of hypertension. Additionally, aberrant neurocirculatory responses to a cold stimulus are associated with an increased risk of hypertension. This study aimed to determine whether salt loading versus salt reduction would impact hemodynamic and sympathetic neural responses during the cold pressor test (CPT) in premenopausal women with a history of normal pregnancy. Nine healthy premenopausal women [42 ± 3 (SD) yr] were given a standardized isocaloric high-salt (HS; 250 mEq sodium/day) or low-salt (LS; 50 mEq sodium/day) diet for 1-wk each (∼2 mo apart with the order randomized), while water intake was ad libitum. Laboratory testing was performed following each HS and LS period in the mid-luteal phase of the menstrual cycle. Subjects were in the supine position and beat-by-beat blood pressure (BP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were continuously measured during 1-min baseline followed by 2-min CPT, and 3-min recovery. BP and HR increased during the CPT (both P < 0.001); the responses were similar between HS and LS. MSNA increased during the CPT, but the increment (Δ) was greater during HS than LS (29 ± 6 vs. 15 ± 4 bursts/min; P < 0.001). The transduction of MSNA for vasoconstriction during the CPT was lower in HS ( P < 0.05). Thus, salt loading augments sympathetic neural reactivity to the cold stimulus with similar pressor responses compared with salt reduction, which may be attributed to the blunted neurovascular transduction—a compensatory mechanism for hemodynamic homeostasis in premenopausal women with a history of normal pregnancy.
Online Prediction of Ship Roll Motion in Waves Based on Auto-Moving Gird Search-Least Square Support Vector Machine
Authors: Xu Chang-Zhou , Zou Zao-Jian
Published: January 2021

A novel method based on auto-moving grid search-least square support vector machine (AGS-LSSVM) is proposed for online predicting ship roll motion in waves. To verify the method, simulation data are used, which are obtained by solving the second-order nonlinear differential equation of ship roll motion using the fourth-order Runge–Kutta method, while the Pierson–Moskowitz spectrum (P–M spectrum) is used to simulate the irregular waves. Combining the sliding time window with the least square support vector machine (LS-SVM), the samples in the time window are used to train the LS-SVM model, and the model hyperparameters are optimized online by the auto-moving grid search (AGS) method. The trained model is used to predict the roll motion in the next 30 seconds, and the prediction results are compared with the simulation data. It is shown that the AGS-LSSVM is an effective method for online predicting ship roll motion in waves.
A Network Flow Algorithm for Solving Generalized Assignment Problem
Authors: Hu Yongwen , Liu Qunpo
Published: January 2021

The generalized assignment problem (GAP) is an open problem in which an integer

k

is given and one wants to assign

k

′

agents to

k

k

′

≤
k

jobs such that the sum of the corresponding cost is minimal. Unlike the traditional

K

-cardinality assignment problem, a job can be assigned to many, but different, agents and an agent may undertake several, but different, jobs in our problem. A network model with a special structure of GAP is given and an algorithm for GAP is proposed. Meanwhile, some important properties of the GAP are given. Numerical experiments are implemented, and the results indicate that the proposed algorithm can globally and efficiently optimize the GAP with a large range cost.
Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential
Authors: Asiedu-Gyekye I. J. , Borovskaya T. G. , Poluektova M. E. , Vychuzhanina А. V. , Shchemerovа Y. А. , Kamalova S. I. , Grgoreva V. A. , Amoateng P. , Kukuia K. E. , Kwapong A. A. , Allotey Babington L. , Amponsah S. K. , N’guessan B. B.
Published: January 2021

Unsweetened natural cocoa (UNCP) was evaluated for reproductive toxicity in rats. A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. White Wistar rats were used in two experimental groups. The females received UNCP 15 days before crossing with untreated males. The males received UNCP for 48 days before mating with untreated females. Subacute toxicity was observed during a 14-day oral administration of UNCP. Results show that a high tail DNA% was observed with methyl mesylate administration in all tissues analysed. The lowest tail DNA% value was observed in the liver (1.64 ± 0.26) and kidney (1.63 ± 0.30) during UNCP (TD) administration. UNCP did not induce observable physical congenital malformations on the pubs of treated female and male rats, lacks genotoxic potential, and did not adversely affect pregnancy index, pub weights, and survival index, but UNCP exhibited proimplantation potential (

p
>
0.05

).
[Retracted] Detection and Adaptive Video Processing of Hyperopia Scene in Sports Video
Authors: Chen Qingjie , Dong Minkai
Published: January 2021

In the research of motion video, the existing target detection methods are susceptible to changes in the motion video scene and cannot accurately detect the motion state of the target. Moving target detection technology is an important branch of computer vision technology. Its function is to implement real‐time monitoring, real‐time video capture, and detection of objects in the target area and store information that users are interested in as an important basis for exercise. This article focuses on how to efficiently perform motion detection on real‐time video. By introducing the mathematical model of image processing, the traditional motion detection algorithm is improved and the improved motion detection algorithm is implemented in the system. This article combines the advantages of the widely used frame difference method, target detection algorithm, and background difference method and introduces the moving object detection method combining these two algorithms. When using Gaussian mixture model for modeling, improve the parts with differences, and keep the unmatched Gaussian distribution so that the modeling effect is similar to the actual background; the binary image is obtained through the difference between frames and the threshold, and the motion change domain is extracted through mathematical morphological filtering, and finally, the moving target is detected. The experiment proved the following: when there are more motion states, the recall rate is slightly better than that of the VIBE algorithm. It decreased about 0.05 or so, but the relative accuracy rate increased by about 0.12, and the increase ratio is significantly higher than the decrease ratio. Departments need to adopt effective target extraction methods. In order to improve the accuracy of moving target detection, this paper studies the method of background model establishment and target extraction and proposes its own improvement.
A Rare Presentation of Renal Papillary Necrosis in a COVID-19-Positive Patient
Authors: Tallai Bela , Gulistan Tawiz Gul , Alrayashi Maged Nasser Aa B. , Al Mughalles Salah Abdulhabeb Abdulwali , Kamkoum Hatem Mostari , Ebrahim Mohamed Ali A. , Abdelkarim Mohamed Abdelkarim Ali , Salah Morshed Ali
Published: January 2021

In this case report we describe an unusual presentation of severe acute papillary necrosis in a COVID-19-positive patient. An emergency flexible ureteroscopy greatly helped in the establishment of the diagnosis. In the international literature, there is a paucity of intraoperative endoscopic images representing severe renal papillary necrosis. We present a case of severe acute renal papillary necrosis in a 49-year-old south-Asian, COVID-19-positive male patient who needed emergency urological intervention for macroscopic hematuria and urinary retention due to clot formation in the urinary bladder. The patient underwent emergency cystoscopy, clot evacuation, and by rigid and flexible ureteroscopy. The diagnosis was only confirmed in the postoperative period, retrospectively. Finally, the patient fully recovered due to the multidisciplinary management. Diagnosis of rare clinical entities can be sometimes challenging in the everyday routine practice. Having atypical clinical course, the surgeon should be prepared and sometimes must take responsible decisions promptly, even if needed intraoperatively, to manage unexpected findings in order to get the right diagnosis without compromising the patient’s safety.
Production-Use Water Pricing and Corporate Water Use in China: An Evolutionary Game Theory Model
Authors: Xiao Yao , Peng Qiao , Xu Wanting , Xiao Hongye
Published: January 2021

Decisions related to pricing production-use water are a critical issue that local governments in China are facing. Its significance has increased in recent years, as a serious corporate water-supply shortage has surfaced with rapid economic development and urbanization. Different from developed countries, the pricing of production-use water is a complex issue in China that involves the distribution of benefits among local governments, water-supply companies, and water-consuming companies, where the overall balance is affected by every slight adjustment. Based on the evolutionary game theory, this study constructs an evolutionary game model involving water-supply companies and water-consuming companies with a systematic analysis of the interaction process between the policy formulation related to water pricing by water-supply companies and the decision making related to water consumption by water-consuming companies. The research finds that the difficulty of balancing corporate financial benefits and public water conservation benefits has led to the complexity of water pricing. Moreover, raising water prices will not necessarily cause companies to save water, but it will increase the production cost of the entire economy. This is the direct cause of low water prices, implemented by water-supply companies, in many regions of China.
New Biomarker in Chagas Disease: Extracellular Vesicles Isolated from Peripheral Blood in Chronic Chagas Disease Patients Modulate the Human Immune Response
Authors: Madeira Rafael Pedro , Dal’Mas Romera Lavínia Maria , de Cássia Buck Paula , Mady Charles , Ianni Barbara Maria , Torrecilhas Ana Claudia
Published: January 2021

Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan Trypanosoma cruzi (T. cruzi), is a major public health problem. It was initially restricted to Latin America, but it is now expanding globally. Host and pathogen interactions are crucial in the establishment of disease, and since 1970, it has been known that eukaryotic cells release extracellular vesicles (EVs), which in turn have an important role in intercellular communication in physiological and pathological conditions. Our study proposed to characterize and compare circulating EVs isolated from the plasma of chronic Chagas disease (CCD) patients and controls. For this, peripheral blood was collected from patients and controls, and mononuclear cells (PBMCs) were isolated and stimulated with parasite EVs, showing that patient cells released fewer EVs than control cells. Then, after plasma separation followed by EV total shedding enrichment, the samples were subjected to ultracentrifugation to isolate the circulating EVs, which then had their size and concentration characterized by nanoparticle tracking analysis (NTA). This showed that patients had a lower concentration of circulating EVs while there were no differences in size, corroborating the in vitro data. Additionally, circulating EVs were incubated with THP-1 cells (macrophages) that, after the interaction, had their supernatant analyzed by ELISA for cytokine detection. In relation to their ability to induce cytokine production, the CCD patient EVs were able to induce a differential production of IFN-γ and IL-17 in relation to controls, with differences being more evident in earlier/less severe stages of the disease. In summary, a decreased concentration of circulating EVs associated with differential activation of the immunological system in patients with CCD is related to parasite persistence and the establishment of chronic disease. It is also a potential biomarker for monitoring disease progression.
Research on Early Warning Mechanism and Model of Liver Cancer Rehabilitation Based on CS-SVM
Authors: Jianzhu Bo , Shuang Li , Pengfei Ma , Yi Zhu , Yanshu Zhang
Published: January 2021

Since the 20th century, cancer has become one of the main diseases threatening human health. Liver cancer is a malignant tumor with extremely high clinical morbidity and fatality rate and easy recurrence after surgery. Research on the postoperative recurrence time and recurrence location of patients with liver cancer has a crucial influence on the postoperative intervention of patients. Evaluation of the clinical manifestations of patients after liver cancer surgery is conducted according to medical knowledge or national standards to determine the main factors affecting liver cancer rehabilitation. In order to better study the mechanism of liver cancer recurrence, this paper uses CS-SVM to predict the recurrence time of liver cancer patients, so as to timely intervene the patients. There are five evaluation indicators which are basic indicators, immune indicators, microenvironment indicators, psychological indicators, and nutritional indicators, respectively. This paper collects the clinical evaluation data of postoperative follow-up visits for patients with liver cancer in a hospital, improves the parameter selection process of the support vector machine by using the search ability of the cuckoo algorithm, and establishes an algorithm-optimized prediction model of support vector machine for the prognosis of liver cancer to predict the location and approximate time of recurrence. According to the clinical evaluation data of patients with liver cancer after surgery, logistics regression, BP neural network, and other related methods are used to predict the prognosis of liver cancer patients after surgery. The prediction effects of several methods are compared, and the superiority of the model is discussed. At the end of this article, we conducted an empirical analysis on the clinical evaluation data of patients with liver cancer after surgery. For the collected samples of 776 liver cancer recurrences after surgery, the established liver cancer prognosis outcome prediction model was used to predict the recurrence time and recurrence location, respectively. The mean square error of recurrence time prediction is 9.2101, which is much smaller than the prediction mean square error of BP neural network of 177.9451; the prediction accuracy of recurrence location is 95.7%, which is much higher than the 63.14% of logistic regression. The empirical analysis results show that the improved support vector machine model based on cuckoo established in this paper can effectively predict the time and location of cancer recurrence.
Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
Authors: Wu Di , Chen Wenlan , Chen Zhichao , Li Qiubai
Published: January 2021

Mixed phenotype acute leukemia (MPAL) is a rare hematological malignancy that lacks consensus on optimal management. We report for the first time two cases of treatment-naïve B/myeloid MPAL patients treated with a novel chemo-free regimen using venetoclax combined with hypomethylating agents, which successfully induced complete remission with tolerable toxicities.
Double Integral-Based Method for Ranking Intuitionistic Multiplicative Sets and Its Application in Selecting Logistics Transfer Station
Authors: Tian Zhiyong , Lin Jian
Published: January 2021

Intuitionistic multiplicative sets can be applied in many practical situations, most of which are based on ranking of intuitionistic multiplicative numbers. This study develops an integral method for ranking intuitionistic multiplicative numbers based on the new definitions of multiplicative score function and accuracy function. The ranking method considers both the risk preference and infinitely many possible values in feasible region. Some reasonable properties of multiplicative score function and accuracy function are studied, respectively. We construct a total order relation on the set of intuitionistic multiplicative numbers. The multiplicative score function and accuracy function are utilized to select the optimal logistics transfer station. A comparison example is developed to highlight the advantage of the risk preference-based ranking method.
Operation Strategies Based on Horizontal Competition and Service Capability Sharing under Demand Disturbance
Authors: Wang Kun , Wu Dongsong
Published: January 2021

The article considers the influence of demand disturbance on price, service capability, and operation mode selection of firms. Firstly, we discuss the equilibrium pricing and service capability strategy of the firm under three operation modes: price and service competition, price competition and service capability sharing, and price and service centralized making-decision. When there is demand disruption, firms determine their pricing and service capacity strategies under the three main operating models above. Finally, the comparative analysis shows that the influence of service capability in centralized decision price and service capability mode is greater than that on service capability in price competition and service capability sharing mode. The smoothness of service capability in price competition and service capability sharing mode is better than that in the centralized decision mode. And when the market price competition coefficient is moderate or the negative demand disturbance occurs, the price competition and service capability sharing mode has little influence on the profit compared with the other two modes (the profit loss is the smallest).
PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates
Authors: Veach Darren R. , Storey Claire M. , Lückerath Katharina , Braun Katharina , von Bodman Christian , Lamminmäki Urpo , Kalidindi Teja , Strand Sven-Erik , Strand Joanna , Altai Mohamed , Damoiseaux Robert , Zanzonico Pat , Benabdallah Nadia , Pankov Dmitry , Scher Howard I. , Scardino Peter , Larson Steven M. , Lilja Hans , McDevitt Michael R. , Thorek Daniel L.J. , Ulmert David
Published: January 2021

Purpose:

Most patients with prostate cancer treated with androgen receptor (AR) signaling inhibitors develop therapeutic resistance due to restoration of AR functionality. Thus, there is a critical need for novel treatment approaches. Here we investigate the theranostic potential of hu5A10, a humanized mAb specifically targeting free PSA (KLK3).

Experimental Design:

LNCaP-AR (LNCaP with overexpression of wildtype AR) xenografts (NSG mice) and KLK3_Hi-Myc transgenic mice were imaged with 89Zr- or treated with 90Y- or 225Ac-labeled hu5A10; biodistribution and subcellular localization were analyzed by gamma counting, PET, autoradiography, and microscopy. Therapeutic efficacy of [225Ac]hu5A10 and [90Y]hu5A10 in LNCaP-AR tumors was assessed by tumor volume measurements, time to nadir (TTN), time to progression (TTP), and survival. Pharmacokinetics of [89Zr]hu5A10 in nonhuman primates (NHP) were determined using PET.

Results:

Biodistribution of radiolabeled hu5A10 constructs was comparable in different mouse models. Specific tumor uptake increased over time and correlated with PSA expression. Treatment with [90Y]/[225Ac]hu5A10 effectively reduced tumor burden and prolonged survival (P ≤ 0.0054). Effects of [90Y]hu5A10 were more immediate than [225Ac]hu5A10 (TTN, P < 0.0001) but less sustained (TTP, P < 0.0001). Complete responses were observed in 7 of 18 [225Ac]hu5A10 and 1 of 9 mice [90Y]hu5A10. Pharmacokinetics of [89Zr]hu5A10 were consistent between NHPs and comparable with those in mice. [89Zr]hu5A10-PET visualized the NHP-prostate over the 2-week observation period.

Conclusions:

We present a complete preclinical evaluation of radiolabeled hu5A10 in mouse prostate cancer models and NHPs, and establish hu5A10 as a new theranostic agent that allows highly specific and effective downstream targeting of AR in PSA-expressing tissue. Our data support the clinical translation of radiolabeled hu5A10 for treating prostate cancer.
ОСОБЛИВОСТІ ВЕДЕННЯ РЕВМАТОЛОГІЧНИХ ХВОРИХ ЗА УМОВ ПАНДЕМІЇ COVID-19: СПІВПРАЦЯ ПЕРВИННОЇ ЛАНКИ ТА РЕВМАТОЛОГА
Authors: Zarudna O. I. , Zarudna D. O.
Published: January 2021

У статті наведено сучасні дані щодо статистичних даних, ризиків інфікування та особливостей перебігу ковідної інфекції у пацієнтів ревматологічного профілю. Висвітлено питання базисного та симптомомодифікуючого лікування аутоімунних ревматичних захворювань за умов пандемії.
МЕТОДИКА ПРОВЕДЕННЯ ДІЛОВОЇ КЛІНІЧНОЇ ГРИ З ТЕМИ «РОБОЧИЙ ТИЖДЕНЬ ДІЛЬНИЧНОЇ МЕДИЧНОЇ СЕСТРИ ДИТЯЧОЇ ПОЛІКЛІНІКИ»
Authors: Bayrachenko R. M.
Published: January 2021

У статті запропоновано приклад проведення ділової клінічної гри «Робочий тиждень дільничної медичної сестри дитячої поліклініки» як засіб формування професійних компетентностей у студентів зі спеціальності 223 «Медсестринство» ОПП «Сестринська справа» в медичних коледжах.
ВИКОРИСТАННЯ НЕТРАДИЦІЙНИХ МЕТОДІВ ОЗДОРОВЛЕННЯ СТУДЕНТІВ СПЕЦІАЛЬНОЇ МЕДИЧНОЇ ГРУПИ НА ЗАНЯТТЯХ ФІЗИЧНОЇ КУЛЬТУРИ В КОМУНАЛЬНОМУ ЗАКЛАДІ «ОДЕСЬКИЙ ОБЛАСНИЙ БАЗОВИЙ МЕДИЧНИЙ ФАХОВИЙ КОЛЕДЖ»
Authors: Tarasenko N. I. , Yurkul S. V.
Published: January 2021

Зі статистичних даних відомо, що кількість студентів, які входять за станом здоров’я до спеціальної медичної групи, протягом останніх років значно зросла. Тому нами у вигляді експерименту застосовано програми з використанням нетрадиційних оздоровчих методик дихальної гімнастики за А. Н. Стрельниковою і звукової гімнастики для оздоровлення студентів зі захворюваннями органів дихання. У результаті дослідження спостерігали чітко виражену тенденцію до збільшення показників функціонального стану кардіореспіраторної системи, підвищення резистентності, працездатності організму та інтересу студентів до занять фізичною культурою в спеціальній медичній групі.
ВИКОРИСТАННЯ НЕЙРОКІНЕМАТОГРАФА В ПІСЛЯДИПЛОМНІЙ ОСВІТІ В УМОВАХ ДИСТАНЦІЙНОГО НАВЧАННЯ
Authors: Solodovnikova Y. O. , Dobrovolskyi V. V. , Son A. S.
Published: January 2021

В умовах пандемії COVID-19 отримання післядипломної освіти змінилося завдяки дистанційному навчанню. Використовуючи програму відеоконференц-звʼязку Microsoft Teams, на кафедрі неврології та нейрохірургії Одеського національного медичного університету інтерни-невропатологи й студенти активно продовжують вивчення неврології. Розбір клінічних випадків після перегляду фільмів, що присвячені неврологічним хворим, тренування у виставленні функціонального та клінічного діагнозів й призначенні лікування доповнюють вимушену нестачу практики з пацієнтами. Нейрокінематограф дозволяє широко охопити такі хвороби, як інсульт, черепно-мозкова травма, хребетно-спинномозкова травма, розсіяний склероз, боковий аміотрофічний склероз, епілепсія, хвороба Паркінсона, хвороба Альцгеймера та ін. Такий сучасний підхід з пильним керівництвом викладачів і можливістю дискусії у режимі реального часу збільшує активність, зацікавленість лікарів-інтернів та студентів.
ДОСВІД ОРГАНІЗАЦІЇ АТЕСТАЦІЇ ВИПУСКНИКІВ ДЛЯ СТУДЕНТІВ СПЕЦІАЛЬНОСТІ 223 «МЕДСЕСТРИНСТВО» У ТЕРНОПІЛЬСЬКОМУ НАЦІОНАЛЬНОМУ МЕДИЧНОМУ УНІВЕРСИТЕТІ ПІД ЧАС ПАНДЕМІЇ COVID-19
Authors: Yastremska S. O. , Reha N. I.
Published: January 2021

Період карантинних заходів, запроваджених в Україні з березня 2020 р. у зв’язку із поширенням COVID-19, паралізував повноцінне життя країни. З’явилися неочікувані виклики, що спричинили трансформацію як у системі охорони здоров’я, так і в медичній освіті. Потреба у підготовці майбутніх лікарів та медичних сестер ніколи не була такою нагальною, як зараз, у контексті глобальної надзвичайної ситуації. У такій ситуації вимушено повинні змінитися методи  та форми навчання, стандартна взаємодія учасників освітнього процесу, зміст навчальних циклів і роль суб’єктів вищої освіти – студентів.

Перед закладами вищої медичної освіти і перед колективом Тернопільського національного медичного університету імені І. Я. Горбачевського МОЗ України (ТНМУ), зокрема, постало питання про термінову зміну умов навчання з очного на дистанційний формат, особливо відкритого і прозорого процесу складання студентами семестрових іспитів та атестації випускників. У даній статті наведений досвід організації проведення атестації випускників для студентів Навчально-наукового інституту медсестринства ТНМУ.
Gradients of connectivity as graph Fourier bases of brain
activity
Authors: Lioi Giulia , Gripon Vincent , Brahim Abdelbasset , Rousseau François , Farrugia Nicolas
Published: January 2021

The application of graph theory to model the complex structure and function of the brain has shed new light on its organization, prompting the emergence of network neuroscience. Despite the tremendous progress that has been achieved in this field, still relatively few methods exploit the topology of brain networks to analyze brain activity. Recent attempts in this direction have leveraged on the one hand graph spectral analysis (to decompose brain connectivity into eigenmodes or gradients) and the other graph signal processing (to decompose brain activity “coupled to” an underlying network in graph Fourier modes). These studies have used a variety of imaging techniques (e.g., fMRI, electroencephalography, diffusion-weighted and myelin-sensitive imaging) and connectivity estimators to model brain networks. Results are promising in terms of interpretability and functional relevance, but methodologies and terminology are variable. The goals of this paper are twofold. First, we summarize recent contributions related to connectivity gradients and graph signal processing, and attempt a clarification of the terminology and methods used in the field, while pointing out current methodological limitations. Second, we discuss the perspective that the functional relevance of connectivity gradients could be fruitfully exploited by considering them as graph Fourier bases of brain activity.
Description of three new species of the genus Mata Distant, 1906 (Hemiptera: Cicadidae: Cicadinae: Oncotympanini) with notes on their natural history from Indian state of Meghalaya, India
Authors: SARKAR VIVEK , MAHAPATRA CUCKOO , MOHAPATRA PRATYUSH P. , NAIR MANOJ V. , KUNTE KRUSHNAMEGH
Published: January 2021

Three new species of the Asian genus Mata Distant, 1906 (Hemiptera: Cicadidae) viz. Mata lenonia sp.nov.; Mata ruffordii sp.nov. and Mata meghalayana sp.nov. are described from Indian state of Meghalaya. Keys and taxonomic descriptions of these species are provided with detailed accounts of their natural history and acoustics.
A new bamboo-feeding species of the leafhopper genus Neurotettix Matsumura (Hemiptera, Cicadellidae, Deltocephalinae) from China
Authors: WANG JING , YANG LIN , CHEN XIANG-SHENG
Published: January 2021

A new bamboo-feeding species of the leafhopper genus Neurotettix Matsumura (Hemiptera, Cicadellidae, Deltocephalinae), Neurotettix spinas sp. nov. is described and illustrated from Guizhou Province, China. A checklist and a key to known species of the genus are also given, and a map showing the geographic distributions of all species of Neurotettix is also provided. The type specimens of the new species are deposited in the Institute of Entomology, Guizhou University, Guiyang, China (GUGC).
Four new species of Serranochromis (Teleostei: Cichlidae) from the Cuanza and Okavango river systems in Angola, including a preliminary key for the genus
Authors: STAUFFER JAY R. JR. , BILLS ROGER , SKELTON PAUL H.
Published: January 2021

The present study describes Serranochromis alvum n. sp., Serranochromis swartzi n. sp., Serranochromis cuanza n. sp., and Serranochromis cacuchi n. sp. from Angolan tributaries of the Cuanza and Okavango systems in Angola. The presence of four or five scale rows between the posterior margin of the orbit and the ascending arm of the preoperculum, the presence of widely set unicuspid teeth on the jaws, widely separated gill rakers, and anal fins with egg ocelli place these four species in Serranochromis. The Serranochromis described herein are distinguishable based on a combination of morphological and meristic characters, as well as pigmentation patterns. The interorbital width (14.3–15.9 % HL) of S. alvum is narrower than that of S. swartzi (17.6–19.8), S. cuanza (16.3–18.0), and S. cacuchi (20.0–21.7). Moreover, the interorbital width of S. cacuchi is greater than the other three described species. Serranochromis swartzi has a smaller preorbital depth (16.2–18.9 % HL) and snout length (29.6–31.9 % HL) than Serranochromis cuanza (PD 19.1–22.2, SNL 35.2–39.6 % HL). Serranochromis alvum is known only from the type locality at Cuito-Cuanavale at the junction of the Cuito and Cuanavale rivers, tributary to the Okavango River in Angola. Serranochromis swartzi is known only from the type locality in the Cuanza River, Angola. Serranochromis cuanza is restricted to the Cuanza River, below Capanda Dam, Angola, while S. cacuchi is known only from the Cacuchi River, a tributary of the Cuchi-Cubango River in Angola. The limited distribution of all four species and the absence of many congeners suggest, that in addition to previous studies that invoked a lacustrine speciation model, vicariance through drainage isolation seems to have played an important role in driving speciation in this group. The minimum polygon clusters that are formed when the first principal components of the meristic data are plotted against the second sheared principal components of the morphometric data show separation of the four new species.
Association of Plasma MiRNA-204 and the Presence and Severity of Coronary Artery Calcification in Patients With Type 2 Diabetes
Authors: Ding Yao-dong , Pei Yu-qiang , Rui-Wang  , Yang Jia-xin , Zhao Ying-xin , Liu Xiao-li , Shen Hua , Ma Qian , Zhang Shuo , Ge Hai-long
Published: January 2021

We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). We consecutively enrolled 179 individuals with T2DM who underwent coronary computed tomography at Anzhen Hospital from January 2015 to September 2016. The CAC score (CACS) was expressed in Agatston units and >10 Hounsfield units were defined as CAC-positive status. Significant CAC was observed in 98 (54.7%) patients. Plasma miR-204 levels (relative expression) were significantly lower in patients with significant CAC than controls (1.001 ± 0.100 vs 0.634 ± 0.211, P < .001). Plasma miR-204 levels were also negatively correlated with the glycosylated hemoglobin A1c (HbA1c) level (r = −0.702, P < .001), CACS (r = −0.710, P < .001), and the United Kingdom Prospective Diabetes Study (UKPDS) score (r = −0.355, P < .001). After multivariate logistic analyses, plasma miR-204 levels were still significantly and independently associated with the presence of CAC (odds ratio = 0.103, CI = 0.018-0.583, P < .001) after adjustment for conventional risk factors. Receiver operating characteristic curve analysis showed that plasma miR-204 levels can predict the severity and extent of CAC, and the specificity was higher than that of the traditional risk factors UKPDS score and HbA1c. In conclusion, the downregulation of miR-204 was independently associated with CAC in patients with T2DM.
Surge protection of centrifugal compressors using advanced anti-surge control system
Authors: Amin Arslan Ahmed , Maqsood Muhammad Taimoor , Mahmood-ul-Hasan Khalid
Published: January 2021

Centrifugal Compressors (CCs) are widely used equipment to transport the natural gas over long-distance pipelines from the gas processing facility to end consumers. Surge protection is of vital importance for such compressors to avoid costly damage to machine and production loss due to process interruption. In this paper, the dynamic behaviour of CCs has been studied during four critical scenarios: high header pressure, low suction pressure, startup of the new unit, and emergency shutdown of the unit. The dynamic simulation has been carried out using HYSYS software and validated with an industrial scale CC plant. The advanced Anti-Surge Control (ASC) consists of a split PID control in contrast to conventional PID control. The simulation results demonstrate the superior performance of advanced ASC over a conventional one for the severe surge in the event of high header pressure and low suction pressure. The occurrence of surge during start-up and the emergency shutdown was handled with the full open operation of the Anti-Surge Valve (ASV). The proposed algorithm has proved successful in protecting the compressor during fast transients of the operating point towards the surge limit line. The study is significant for the oil and gas plants and other process industry professionals for designing effective ASC systems.