bluuebunny/crossref_metadata_2025 huggingface dataset:
Construção de videocasts sobre as especialidades por área do enfermeiro: relato de experiência
Authors: Souza Sobreira Laís , Cardoso da Silva Fabiana , Costa da Rocha Sânia Nara , Nunes Veras Filho Rubens , Pedrosa Moreira Deborah
Published: November 2024

O estudo objetiva descrever a construção de videocasts sobre as especialidades por área do enfermeiro. Trata-se de um relato de experiência, realizado nos meses de agosto a novembro de 2023, em Fortaleza-CE. O trabalho se deu em três etapas bem definidas: organização e estruturação de roteiro; gravação em estúdio; e publicação na plataforma Youtube e divulgação do produto em redes sociais, como Instagram e WhatsApp. Ao todo, foram produzidos quatro vídeos, sendo a média deles de 4min29seg, abordando as especialidades por área de abrangência do enfermeiro. Vale frisar que os videocasts são ferramentas promissoras para propagação de informações, principalmente na área da saúde.
Διαγνωστικά μοντέλα γεροντικής κατάθλιψης βασισμένα στην απεικόνιση της λευκής ουσίας του εγκεφάλου με μαγνητικό συντονισμό
Authors: Σιάρκος Κώστας
Published: November 2024

Σκοπός της παρούσας έρευνας ήταν η ανάπτυξη ενός μοντέλου μηχανικής μάθησης, για τη διάγνωση της μείζονος κατάθλιψης σε άτομα προχωρημένης ηλικίας, με βάση ένα προηγμένο πλαίσιο διαχωρισμού της λευκής ουσίας του εγκεφάλου. Είκοσι έξι άτομα με μείζονα κατάθλιψη και δώδεκα υγιείς μάρτυρες, ηλικίας άνω των 55 ετών, με ανάλογες ηλικίες, MMSE και εκπαίδευση, υποβλήθηκαν σε MRI διάχυσης και διαχωρισμό της λευκής ουσίας, με βάση πολλαπλούς δείκτες και άτλαντες απεικόνισης του τανυστή διάχυσης, εντός της πλατφόρμας MRIcloud. Ο όγκος της κλασματικής ανισοτροπίας, της διάχυσης και οι μέσες τιμές της κλασματικής ανισοτροπίας, του ίχνους της διάχυσης και της διαχυσιμότητας κατά τον επιμήκη και κάθετο άξονα διάχυσης, όπως εξήχθησαν από 146 τμήματα της λευκής ουσίας, χρησιμοποιήθηκαν για την εκπαίδευση και τον έλεγχο του ταξινομητή Adaboost, με μεθόδους εξωτερικής εγκυρότητας. Η επίδοση αξιολογήθηκε χρησιμοποιώντας κατάλληλα μέτρα ακρίβειας και ευαισθησίας, την τιμή F1 και την περιοχή που περικλείεται από την καμπύλη ROC. Η στατιστική σημαντικότητα του ταξινομητή εξετάσθηκε χρησιμοποιώντας τυπικές μεθόδους ανάμειξης των διαγνωστικών κατηγοριών (permutation testing) μαζί με μεθόδους εξωτερικής εγκυρότητας. Ο ταξινομητής πέτυχε σταθμισμένη ακρίβεια, 71% και τιμές της περιοχής που περικλείεται από την καμπύλη ROC, 0.81, με το δείκτη του ίχνους της διάχυσης (diffusion trace) και σταθμισμένη ακρίβεια, 70% και τιμές της περιοχής που περικλείεται από την καμπύλη ROC, 0.80, με το δείκτη της διαχυσιμότητας κατά τον κάθετο άξονα (radial diffusivity) εντός «μεταιχμιακών» οδών, του κυκλώματος φλοιός-βασικά γάγγλια-θάλαμος-φλοιός, του στελέχους, της έσω και έξω κάψας, του μεσολοβίου και της παρεγκεφαλίδας. Οι δυο δείκτες μοιράζονταν κοινές δομές, ως σημαντικές για τη διαγνωστική ταξινόμηση, ενώ η ψαλίδα ήταν η πιο σημαντική δομή για την ταξινόμηση και με τους δύο δείκτες. Ο ταξινομητής αποδείχθηκε στατιστικά σημαντικός, αφού οι τιμές της περιοχής που περικλείεται από την καμπύλη ROC, μετά την ανάμειξη των χαρακτηριστικών, ήταν χαμηλότερες από εκείνες με τα πραγματικά δεδομένα (P = 0.022, για το δείκτη trace και P = 0.024 για το δείκτη radial diffusivity). Τα αποτελέσματα ενθαρρύνουν την περαιτέρω διερεύνηση των εφαρμοζόμενων μεθόδων στο χαρακτηρισμό της γεροντικής κατάθλιψης και την υποβοηθούμενη από υπολογιστή διαγνωστική και θεραπευτική, βασισμένα στις ανατομικές διαφορές του εγκεφάλου.
Διερεύνηση του ρόλου της τραχηλικής μικροβιακής χλωρίδας και της σύστασης του αμνιακού υγρού σε σχέση με την εξέλιξη της κύησης
Authors: Γιασλακιώτης Βασίλειος
Published: November 2024

Στόχος της μελέτης ήταν ο προσδιορισμός της συχνότητας της μικροβιακής εισβολής στην αμνιακή κοιλότητα σε ασθενείς που υποβλήθηκαν σε αμνιοπαρακέντηση λόγω κλινικών ενδείξεων στο δεύτερο τρίμηνο της κύησης. Πραγματοποιήθηκε προοπτική διερεύνηση του αμνιακού υγρού 114 ασυμπτωματικών γυναικών για την παρουσία μικροβιακού DNA. Τα αμνιακά δείγματα ελήφθησαν κατά την αμνιοπαρακέντηση γενετικού ελέγχου από γυναίκες μεταξύ 15-22 εβδομάδων κύησης και ελέγχθηκαν ειδικά για την παρουσία Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum, καθώς και για άλλα βακτήρια χρησιμοποιώντας PCR ευρείας κλίμακας. Οι εκβάσεις των κυήσεων μελετήθηκαν ανεξάρτητα από τα αποτελέσματα των μοριακών δοκιμών. Χρησιμοποιώντας κλασική και πραγματικού χρόνου PCR, ο επιπολασμός της μικροβιακής εισβολής στην αμνιακή κοιλότητα σε γυναίκες μεταξύ 15 και 22 εβδομάδων κύησης ήταν 0%. Πρόωρος τοκετός συνέβη μόνο σε δύο γυναίκες. Στη μία με πρόκληση και στη μία αυτόματα. Δε συσχετίσθηκε με Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum. Επιπλέον, η PCR δεν αποκάλυψε την παρουσία άλλων βακτηριακών μικροβίων. Εν τέλει, δεν ανιχνεύθηκε με μοριακές μεθόδους μικροβιακή εισβολή στην αμνιακή κοιλότητα εγκύων γυναικών χαμηλού κινδύνου κατά το δεύτερο τρίμηνο της κύησης.
Μελέτη των λιποκινών που εκκρίνονται από τον επικαρδιακό λιπώδη ιστό στους καρδιοχειρουργικούς ασθενείς
Authors: Λιακοπούλου Αλεξάνδρα
Published: November 2024

ΕΙΣΑΓΩΓΗ: Οι αντιποκίνες που παράγονται από τον λιπώδη ιστό έχουν βρεθεί ότι εμπλέκονται στην παθοφυσιολογία των μεταβολικών και καρδιαγγειακών παθήσεων. Τα επίπεδα ορού συγκεκριμένων αντιποκινών, συμπεριλαμβανομένης της λεπτίνης, της αντιπονεκτίνης, της ρεζιστίνης και της πρωτεΐνης 4 που δεσμεύει τη ρετινόλη (RBP4), έχουν συσχετιστεί με την ανάπτυξη στεφανιαίας νόσου (ΣΝ), υποδηλώνοντας πιθανό ρόλο αυτών των αντιποκινών στην παθογένεση της ΣΝ. ΣΚΟΠΟΣ: Η διερεύνηση των σχέσεων της ρεζιστίνης, RBP4 και της αντιπονεκτίνης που παράγεται από τον επικαρδιακό λιπώδη ιστό με τη ΣΝ και την καρδιακή δομή και λειτουργία. ΥΛΙΚΟ ΚΑΙ ΜΕΘΟΔΟΣ: Εξετάστηκαν 41 μη διαβητικοί άνδρες που είχαν προγραμματιστεί για καρδιοθωρακική επέμβαση. Προεγχειρητικά πραγματοποιήθηκαν ανθρωπομετρικές μετρήσεις, υπερηχοκαρδιογραφία, στεφανιογραφία και εξετάσεις αίματος. Μετρήθηκαν τα επίπεδα στον ορό της ρεζιστίνης, της RBP4 και της αντιπονεκτίνης και της έκφρασης των mRNA τους στο θωρακικό υποδόριο λιπώδη ιστό και σε δύο δείγματα επικαρδίου λιπώδους ιστού, ένα κοντά στον αριστερό πρόσθιο κατιόντα κλάδο (LAD) (resistin-LAD, RBP4-LAD, adiponectin-LAD) και ένα άλλο κοντά στη δεξιά στεφανιαία αρτηρία (RCA) (resistin-RCA, RBP4-RCA, adiponectin-RCA). ΑΠΟΤΕΛΕΣΜΑΤΑ: Το κλάσμα εξώθησης της αριστερής κοιλίας συσχετίστηκε αρνητικά με την αντιπονεκτίνη-LAD (rho = - 0,390, p = 0,025). Ο λόγος των κυμάτων Ε/Α (διαμιτροειδική ροή), ως δείκτης της διαστολικής λειτουργίας της αριστερής κοιλίας, συσχετίστηκε αρνητικά με την ρεζιστίνη-LAD (rho = − 0,529, p = 0,024) και το RBP4-LAD (rho = − 0,458, p = 0,04). Δεν υπήρχε διαφορά στην επικαρδιακή έκφραση mRNA ρεζιστίνης, RBP4 και αντιπονεκτίνης μεταξύ ατόμων με ΣΝ και εκείνων χωρίς ΣΝ. Όταν συγκρίναμε τα άτομα με ΣΝ στο LAD με αυτά χωρίς ΣΝ στο LAD, δεν υπήρχε διαφορά στη resistin-LAD, RBP4-LAD και adiponectin-LAD. Δεν υπήρχε διαφορά στη ρεζιστίνη-RCA, RBP4-RCA και αντιπονεκτίνη-RCA μεταξύ των ατόμων με ΣΝ στην RCA και εκείνων χωρίς ΣΝ στην RCA. ΣΥΜΠΕΡΑΣΜΑΤΑ: Η αύξηση της έκφρασης του mRNA της αντιπονεκτίνης στον επικαρδιακό λιπώδη ιστό συσχετίστηκε με συστολική δυσλειτουργία της αριστερής κοιλίας, ενώ η έκφραση mRNA τόσο της ρεζιστίνης όσο και της RBP4 συνδέθηκε με τη διαστολική δυσλειτουργία της αριστερής κοιλίας.
Interlaminar fracture toughness of layered materials under high-speed loading conditions
Authors: Κοτσίνης Γεώργιος
Published: November 2024

Η παρούσα διατριβή ασχολείται με την δυσθραυστότητα των σύνθετων πλακών και των κολλητών συνδέσμων υπό συνθήκες υψηλής ταχύτητας φόρτισης, με έμφαση στην επίδραση της ελαστικής ταλάντωσης του δοκιμιού κατά την διάρκεια της φόρτισης. Αναλυτικά εργαλεία αναπτύσσονται για τον υπολογισμό της δυναμικής δυσθραυστότητας και για την περιγραφή της απόκρισης σε ταλάντωση, δοκιμίων τύπου δοκού που περιέχουν μια ρωγμή. Αυτά τα εργαλεία στη συνέχεια επαληθεύονται με χρήση αριθμητικών μεθόδων. Τέλος προτείνεται μια νέα πειραματική διάταξη για την πειραματική δοκιμή υπό υψηλές ταχύτητες φόρτισης. Η τρέχουσα κατανόηση του πώς η δυσθραυστότητα επηρεάζεται από τον ρυθμό φόρτισης είναι ασαφής. Διάφορες πειραματικές διατάξεις, αναλυτικά μοντέλα και αριθμητικά εργαλεία έχουν χρησιμοποιηθεί για να διερευνήσουν αυτή τη σχέση. Ωστόσο, κάθε μέθοδος έχει τα πλεονεκτήματά της και τους περιορισμούς της, οι οποίοι μπορεί να επηρεάσουν την παρατηρούμενη εξάρτηση της δυσθραυστότητας από τον ρυθμό φόρτισης. Η σημαντικότερη συνεισφορά της παρούσας διατριβής εντοπίζεται στα εξής δύο σημεία: • Ανάπτυξη ανανεωμένων αναλυτικών εργαλείων για τον υπολογισμό της δυναμικής δυσθραυστότητας για δυο κατηγορίες υλικών: πολύστροφες πλάκες και κολλητούς συνδέσμους. • Χρήση αυτών των εργαλείων για να φανερωθεί η εξάρτηση της δυναμικής δυσθραυστότητας με τον ρυθμό φόρτισης. Στόχοι της διδακτορικής διατριβής. Ο γενικός στόχος της διατριβής είναι να βρεθεί αν η ελεύθερη ταλάντωση κατά την φόρτιση επηρεάζει την δυναμική δυσθραυστότητα του δοκιμιού. Για να επιτευχθεί αυτός ο στόχος αναλυτικά εργαλεία καθώς και μια υβριδική (αναλυτική - πειραματική) μέθοδος προτείνεται. Ο άνω στόχος χωρίστηκε στους παρακάτω επιμέρους στόχους: • Κριτική αξιολόγηση της υπάρχουσας επιστημονικής γνώσης στο πεδίο. • Δημιουργία ενός αναλυτικού μοντέλου που περιγράφει την κίνηση του δοκίμιο κατά την διάρκεια του πειράματος. • Εξαγωγή των αναλυτικών λύσεων για τον υπολογισμό της δυναμικής δυσθραυστότητας. • Επιβεβαίωση της ακρίβειας του αναλυτικού μοντέλου με χρήση της μεθόδου πεπερασμένων στοιχείων. • Σύγκριση με άλλες λύσεις στην βιβλιογραφία. • Εφαρμογή των αναλυτικών μοντέλων σε πειραματικά αποτελέσματα. • Μελέτη της επιρροής του ρυθμού παραμόρφωσης στην δυναμική δυσθραυστότητα.
Artistic expression as a property of resonant musical experience: an interview study with upper secondary school music teachers
Authors: Tullberg Markus
Published: November 2024

Background The curriculum for the courses given at the music specialization of the upper secondary school’s aesthetic program in Sweden includes the concept of artistic expression (AE). Being a criterion for assessment, no definition is provided by the National Agency of Education and there exists no consensus of how to interpret artistic expression among music teachers and music teacher students. Methods In order to explore how teachers understand, teach, and assess the concept and phenomenon of artistic expression, twelve qualitative interviews with music teachers were conducted and analyzed through an open coding process. Results The findings show that the concept of artistic expression is multifaceted and evasive. The results focus on two analytic threads: (i) situatedness and (ii) entanglement. (i) AE is situated due to context-specific parameters which underpins the meaning of the concept in this particular educational setting. (ii) Furthermore, the phenomenon of artistic expression is entangled (a) with the ongoing relationship between teacher and student, and (b) in a temporally unfolding and interactive musical event. The phenomenon of artistic expression as entangled is discussed, primarily through Hartmut Rosa’s concept of resonance, which brings into focus the intersubjective character of aesthetic experience. Doing so questions understandings of – and assessment procedures surrounding – artistic expression that relies on skill-based interpretations or reductions of entanglement. One example of such reduction is assessment of recordings of student performances which limits (a) the relational perspective (if assessed by a third person) or (b) the entanglement with the musical event. The perspective of resonance brings forth the teacher’s role during a student performance as characterized by self-efficacy and active listening, thus co-constitutive of artistic expression. Conclusions The article concludes with reflections on how the findings may contribute to the continuous discussion on how scientific grounding and proven experience may inform both the music education at upper secondary school and music teacher education. The concept of resonance provides a possibility to reframe conceptions of artistic competence in art education as being grounded in intersubjective and relational terms, rather than being reified as a set of measurable skills, an understanding which in turn risks replacing learning with criteria compliance.
Changes in prevalence and patterns of consanguinity in Bradford, UK – evidence from two cohort studies
Authors: Small Neil , Kelly Brian , Wright John
Published: November 2024

Background Research undertaken using the Born in Bradford cohort study identified consanguinity as a major risk factor for congenital anomalies and also reported longer term adverse health outcomes associated with consanguinity. Methods We report the prevalence of consanguinity from two cohort studies in the same geographical area with a nine year gap: Born in Bradford (BiB) and Born in Bradford’s Better Start (BiBBS). We examine and compare rates of consanguinity and the characteristics of the consanguineous in each study population to examine if and how these have changed in the years between the recruitment periods of 2007–2010 (BiB) and 2016–2019 (BiBBS). Results There had been a substantial decrease in consanguineous unions in women of Pakistani heritage, the proportion of women who were first cousins with the father of their baby fell from 39.3% to 27.0%, and those who were other blood relations fell from 23.1% to 19.3%. Only 37.6% of Pakistani heritage women were unrelated to the father of their baby in BiB, but 53.7% were unrelated in BiBBS. All but one White British respondent was unrelated to their baby’s father in both cohorts, and around 90% of the ‘Other ethnicities’ group (i.e., not White British or Pakistani heritage) were unrelated to the baby’s father in both cohorts. The reduction was most marked in women of Pakistani heritage who were born in the UK, in those educated to A level or higher and in women under age 25. Conclusions An appreciation of changing rates of consanguinity and linked health needs will be valuable to those who commission and provide antenatal, paediatric and genetic services in Bradford and in other areas where consanguinity is likely to be a major risk factor. Falling rates in this city may reflect wider changes in partner choices in similar populations.
On the algebraic property of locally convex topological algebras
Authors: Ansari-Piri Esmaeil , Fattahi-Solaymandarabi Banafsheh
Published: November 2024

By a Fréchet algebra, we mean a complete metrizable locally convex topological algebra. The boundedness of a set in Fréchet algebras is of course a topological property, but the uniform bound of a uniformly bounded set is an algebraic property, since it depends on the choice of seminorms generating the same topology on Fréchet algebra. In this paper, we show that if S is a bounded subsemigroup of a Fréchet algebra (A; (pn)n∈N), then there is an equivalent family of seminorms (tn)n∈N on A, such that tn(s)≤1 (s∈S; n∈N). In the rest of this paper, we get a result by using this fact, and we also have a discussion on continuous inverse algebras.
Klasa, kapitał i coaching w dobie późnego kapitalizmu. Perswazja neoliberalnego urządzania
Authors: Mokrzan Michał
Published: November 2024

Przedmiotem podejmowanych w monografii analiz jest splot „klasy–kapitału–coachingu”, który jest rozpatrywany w kontekście procesu rozpowszechniania się w dobie późnego kapitalizmu idei przedsiębiorczości, odpowiedzialności indywidualnej oraz uekonomicznienia stosunków nieekonomicznych. Coaching – rozumiany jako materializacja neoliberalnych technologii urządzania – jest praktyką materialno-symboliczną zachęcającą członków wyższych klas średnich w Polsce do podejmowania prób rozwijania form kapitału emocjonalnego (samoświadomości, postaw przedsiębiorczości i odpowiedzialności, pewności siebie oraz poczucia własnej wartości, odporności psychicznej i umiejętności zarządzania emocjami) w celu radzenia sobie z wyzwaniami stawianymi przez kapitalizm. Członkowie wyższych klas średnich, biorący udział w prowadzonych przez autora badaniach etnograficznych, budują tożsamość klasową w procesie afektywnej pracy nad sobą, inicjowanej w coachingu, która wypływa z potrzeby zyskania i/lub poszerzenia wymienionych wyżej dyspozycji emocjonalno-kognitywnych. Coaching jest narzędziem zarówno tę potrzebę zaspokajającym, jak i ją produkującym. Jest on mechanizmem konstruującym neoliberalne podmioty wyższych klas średnich, wyposażającym je nie tylko w kapitał emocjonalny, lecz także kategorie, na podstawie których sami działają i myślą o sobie oraz otaczającym świecie. Książka dowodzi, że pracę coachingową odpowiedzialną za wytwarzanie neoliberalnych podmiotów wyższych klas średnich konstytuuje mechanizm retoryczny i polityczny, który dookreśla etykieta stanowiąca także drugi człon tytułu monografii: perswazja neoliberalnego urządzania.
Bisphenol A (BPA) as a Contributing Factor to Decreased Fertility in Humans: a Review of the Latest Evidence
Authors: Kania Martyna , Adamowska Agnieszka , Śniatała Alicja , Bartkowiak Hanna , Grubski Damian , Ziarnik Kacper , Nadolny Filip , Jabłoński Jędrzej
Published: November 2024

IntroductionBisphenol A (BPA) is a synthetic compound widely used in producing consumer plastics like polycarbonate and epoxy resins. Recognized as an endocrine-disrupting chemical (EDC), BPA has been linked to various adverse health effects, including impacts on human fertility. Exposure to BPA has been associated with infertility risks not only through direct mechanisms but also by causing transgenerational effects, potentially compromising fertility in future generations.
Aim of the StudyThis review aims to summarize recent evidence identifying BPA as an environmental contributor to infertility in humans. We explore mechanisms through which BPA disrupts the endocrine system, focusing on its effects on the hypothalamic-pituitary-gonadal (HPG) axis, oogenesis, spermatogenesis, and embryo implantation. Additionally, we discuss research on BPA’s potential long-term reproductive risks across generations and assess strategies for reducing BPA exposure.
Materials and MethodsWe reviewed epidemiological, clinical, and experimental studies published over the past decade, with a search conducted in PubMed and Google Scholar. Both human and animal model studies were considered to provide a comprehensive perspective. Search terms included "Bisphenol A," "fertility," "endocrine disruptors," "spermatogenesis," "oogenesis," and "transgenerational effects."
ConclusionsBPA, an EDC ubiquitous in the environment, is shown to disrupt male and female fertility. Expanding research and regulatory measures are needed to reduce the reproductive health risks posed by BPA exposure to protect current and future generations.
Wybrane tradycje performatywne Kerali: (Indie Południowe)
Authors: Sudyka Lidia
Published: November 2024

The present publication is the result of fieldwork done by Indology students from Jagiellonian University, Krakow in the South Indian state of Kerala. The participants became acquainted with the performing traditions of the region by watching performances, talking to artists and learning about the centres and methods of training adepts and continuators of traditional performing arts.
The result is a concise compendium that encourages further study and introduces the colourful and diverse world of stage forms still alive in Kerala. Classical forms such as Sanskrit theatre Kudiyattam and Nangyar Kuttu (essay by Karolina Dylong), Kathakali dance drama (essay by Julia Lachowska and Agnieszka Wójcik) and its puppet version Pavakathakali (essay by Eliza Łach) are discussed here as well as Tolpavakuttu shadow theatre (essay by Zuzanna Szymczyk), Mohiniyattam dance (essay by Natalie Jagło and Natalia Migas) and Teyyam ritual performance (described by Weronika Wyłupek). Each of these chapters consists of background information based on various studies, articles and monographs, and then the authors describe the specific performances they witnessed, documented by the photographs taken by the participants of the Kerala expedition. The Kerala musical instruments that accompany the performances are also introduced and described by Aleksandra Dudra. Since cyclical festivals in Kerala provide an opportunity to showcase certain stage forms, two of the articles describe the Mahaśivaratri and Attukal Pongala festivals as the setting for the performances (articles by Karolina Mucha and Weronika Drozd).
Metadata matching 101: what is it and why do we need it?
Authors: Tkaczyk Dominika , Buttrick Adam
Published: November 2024

At Crossref and ROR, we develop and run processes that match metadata at scale, creating relationships between millions of entities in the scholarly record. Over the last few years, we've spent a lot of time diving into details about metadata matching strategies, evaluation, and integration. It is quite possibly our favourite thing to talk and write about! But sometimes it is good to step back and look at the problem from a wider perspective. In this blog, the first one in a series about metadata matching, we will cover the very basics of matching: what it is, how we do it, and why we devote so much effort to this problem.
Ultraviolet Inactivation of Escherichia coli in Stainless Steel Cups
Authors: Mok Chulkyoon , Lee Nam-Hoon
Published: November 2024

Ultraviolet (UV) is widely used as a sterilizing agent in restaurants and catering facilities in Korea. Efficacy of UV sterilizers (UVS) was investigated against E. coli on the inner bottom of stainless steel cups. UV intensity on the bottom of cups varied widely with the locations of cups in UVS, showing higher values at center while lower values at outskirts. The deviations in UV intensity were remarkable on top shelf, but alleviated as proceeded to middle and bottom shelves. Inactivation of E. coli was proportional to the UV intensity and treatment time, consequently to UV dose, and showed a pseudo-first-order kinetics with tailing. Initial inactivation rate constants (K1) deviated with the locations of the cups, while final inactivation rate constants (K2) showed comparable values. An equation for the calculation of the proposed UV treatment time was suggested.
Extraction of Quercetin and Its Glucosides from Onion Edible Part Using Solvent Extraction and Various Extraction Assisting Methods
Authors: Jin Eun Young , Park Young-Seo , Jang Jae Kweon , Chung Myong-Soo , Park Hoon , Shim Kun-Sub , Choi Young Jin
Published: November 2024

Quercetin is one of the main flavonoids from onion. To use quercetin as a functional component for onion food products, the effects of various extraction assisting methods such as juicing methods, microwave, ultrasound and enzyme treatments on the yield of quercetin and its glucosides were investigated. For conventional solvent extraction, the highest yield of quercetin and its glycosides was achieved with 0.8 mL/g of 60% methanol at 50°C for 15 min. The juicing methods using mixer and screw showed no influence on the yield. Microwave and ultrasound treatments showed 2.14 times and 2.06 times more quercetin yields than non-treated extraction, respectively. For cellulase and viscozyme treatments, the highest yields of quercetin were achieved with 0.5 mL/g of 1% enzyme-0.1M sodium acetate (pH 5.2) buffer solution. Cellulase and viscozyme treatment improved quercetin yield 1.65 times and 2.29 times more than non-treated one, respectively.
Physicochemical Properties and Consumer Acceptance of Tofu Incorporated with Yakong
Authors: Lee Jun Ho , Han Ji Yoon
Published: November 2024

Tofu has been playing an important role in people's daily diet in most of Asia and recently in North America due to several health-promoting functions, preventing and treating a number of chronic diseases such as cancer, coronary heart disease and osteoporosis. The objective of this study was to investigate the effect of different levels of yakong incorporation (0, 5, 10, and 15%, w/w) in preparation of firm tofu. Quality parameters such as pH, titratable, moisture content, color, and consumer preference were determined, and their correlations were analysed. There were no significant differences in pH, titratable acidity, and moisture content due to different levels of yakong incorporation studied (p>0.05). A significant decrease in L* and b*-values whereas significant increase in a*-value was observed (p<0.05). Five percent yakong tofu received the most favorable mean scores with respect to color, texture, and overall acceptability. Correlation analysis revealed that yakong incorporation was well correlated with some of physicochemical properties as well as consumer preference.
Improving Productivity of Pravastatin, HMG-CoA Reductase Inhibitor
Authors: Jeon Dong-Soo , Bai Dong-Hoon
Published: November 2024

Pravastatin sodium, competitive inhibitors of HMG-CoA(3-hydroxy-3-methylglutaryl coenzyme A) reductase, is produced from the culture broth of Streptomyces carbophilus KCCM 10370, The production of Pravastatin sodium was increased about 45 fold compared to wild type by UV mutation. Production of Pravastatin was also improved by continuous feeding of Compactin sodium to 24% and bioconversion ratio was also increased to 4.3% by intermittent addition. In main culture, concentration of Compactin sodium was kept less than 0.1%(w/v) under continuous feeding of Compactin sodium then product was 0.49% and bioconversion was 70%. After finishing the fermentation, Pravastatin was purified by various chromatographies such as Diaion HP20 resin column, Partition, and ODS(Octa-Decylsilyl Silicagel) resin column with a final yield of 70~72% and over 99.7% purity. The IR, UV, and NMR study of the purified Pravastatin sodium showed the same pattern as that of EP(European Pharmacopoeia).
Effect of DIS Process on in vitro Physiological Functionality of Aloe vera Gel
Authors: Kim Sung-A , Baek Jin-Hong , Lee Shin-Young
Published: November 2024

In vitro physiological functions such as jack bean (Canavalia ensiformis) urease inhibitory activity and retarding effect of glucose/bile acid of Aloe vera gel concentrated by the optimized DIS (Dewatering Impregnation & Soaking) process conditions were examined. Urease inhibitory activity of DIS aloes ranged from 84.6 to 94.4%, which was similar to or higher than 86.3% of fresh aloe. Also, urease inhibitory activity of DIS aloes was maintained at initial levels after heat treatment (90°C, 10 min.) and drying treatment (freeze or hot air drying). Urease inhibition pattern from Lineweaver-Burk plot indicated general non-competitive inhibition, and inhibition constants (KIE and KIES) of DIS aloes were 41-149 and 87-163 μL/mL, respectively. DIS(glucose) and DIS(polyethylene glycol) exhibited the highest retarding effect of glucose and bile acid. Their retarding effects were about 1.6 and 1.8 folds higher than that of fresh aloe after 0.5 and 1 hr of the dialysis, respectively. Conclusively, the above in vitro physiological functions of Aloe vera gel concentrated by DIS process suggested that aloe products treated with DIS would have the potential benefits for protection against Helicobacter pylori and reduction of blood glucose and cholesterol levels.
Performance Evaluation of Rough Rice Low Temperature Drying Using Heat Pump
Authors: Kim Hoon , Han Jae-Woong
Published: November 2024

This study was conducted to design and fabricate a heat pump that can produce some weather conditions similar to those of the dry season of the rough rice in Korea, and to investigate basic performances of the apparatus. During the drying test, the amount of energy consumption and drying characteristics were measured at four different temperature levels ranging between 20°C and 50°C. In the psychrometric chart, the freezing capacity and refrigerant circulation ratio of the heat pump were 173 kJ/kg and 49.6 kg/hr, respectively. Therefore, coefficient of performance was 5.5, which was superior to that of refrigerant R-22 (4.0) in standard refrigeration cycle. In addition, the time to reach target drying temperature (30°C) and relative humidity (40%) were 6 minutes and 7 minutes, respectively. Temperature differences between the drying temperature and the rice were 1.5°C and 8.5°C at the drying temperatures of 21.9°C and 48.7°C, respectively. This result demonstrated that the increased temperature of the rice in the drying section decreased sufficiently in the tempering section. At the drying temperatures of 21.9, 30.7 38.8, and 48.7°C, drying rates were 0.29, 0.61, 0.85, and 1.26%/hr, respectively, which were similar to those of commercial dryer. In addition, the amounts of energy consumption were 325, 667, 692, and 776 kJ/kg, respectively. These results showed that this dryer saved up to 86% of energy consumption compared with the commercial dryer, which uses 4,000-5,000 kJ/kg of fossil fuel.
Purification of Carp Serum Metallothionein Induced in Carp with Cadmium and Production of Polyclonal Antibody
Authors: Ryu Hyung-Seok , Kang Ho-Joon , Kim Seul Ki , Kim Namsoo , Kim Woo-Yeon
Published: November 2024

Metallothioneins (MTs) are low molecular weight, cysteine-rich, and heavy metal binding proteins, which could be induced with heavy metals such as Cd, Hg, Zn and Cu in liver, kidney, and in cultured cells. By using ion exchange chromatography on DE-52, MT was purified from the serum of carp induced with cadmium in order to produce antibody against MT. Polyclonal antibody produced against purified carp MT reacted well with MT in the serum of carp induced with cadmium, whereas control serum did not. This may indicate that the polyclonal antibody against the carp MT could be used for the preparation of biosensors to detect MT in fishes like carp.
Combined Effects of Vital Gluten, Gum, Emulsifier, and Enzyme on the Properties of Rice Bread
Authors: Kim Kyung-Eun , Lee Young-Tack
Published: November 2024

The effects of adding additives such as vital gluten, gum, emulsifier, and enzyme to rice flour on baking quality were examined. The effects of different gums on the pasting and dough properties of rice flour containing vital gluten were studied using a Rapid Visco Analyzer (RVA) and a Brabender farinograph. The RVA peak, breakdown, and final viscosities decreased with the addition of gums, while setback viscosity increased. The farinogram showed that rice flour supplemented with gums such as tara gum, guar gum, and locust bean gum (LBG) increased water absorption and dough stability, yielding strengthened dough similar to wheat flour dough. The addition of guar or tara gum/sodium stearoyl lactylate (SSL)/fungal α-amylase (AMYL) or glucose oxidase (GO) blend improved the volume and reduced the crumb firmness of rice bread prepared from rice flour containing 14% vital gluten. Therefore, the combined addition of gum, emulsifier and enzyme into rice flour significantly improved the rice bread quality, allowing the decrease of the vital gluten level in rice bread formula.
Manufacturing and Characteristics of Fruit Wine from Acanthapanax sessiliflorus
Authors: Choi Jae-Myoung , Kim Kwang-Yup , Lee Sang-Hwa , Ahn Jun-Bae
Published: November 2024

Fruit wine from Acanthopanax sessiliflorus(A. sessiliflorus) including many pharmacological components was manufactured and its functional properties were investigated. The fruit part of A. sessiliflorus contained 75.74±0.49%(w/ w) moisture, 12.51±1.23%(w/w) crude protein, 4.20±0.51.%(w/w) crude fat and 5.21±1.64%(w/w) crude ash. Minerals of fruit were potassium(12.94±0.08 mg/g), calcium(1.53±0.06 mg/g) and magnesium(1.12±0.05 mg/g). Initial soluble solid and fermentation temperature were 24-30oBrix and 20°C for manufacturing fruit wine from A. sessiliflorus. When initial soluble solid of a must was adjusted to more than 30°Brix, ethanol production was suppressed slightly. The polyphenol content of the fruit wine fermented at 20°C(125.24±1.86 mg/mL) was higher than those at 25°C(99.69±2.11 mg/mL) and 30°C(95.55±1.54 mg/mL). Electron donating activities of wines fermented at 20, 25 and 30°C were 85.9±2.3, 55.7±2.5 and 55.2±3.4%, respectively. The content of eleutheroside B increased up to 146.58±4.10 μg/mL during fermentation. There was no significant effect of fermentation temperature on eleutheroside B content. The fruit part of A. sessiliflorus can be used as a valuable resource for development of nutraceutical foods.
Glass Slide-based Immunosensing for C-Reactive Protein Using Quantum Dot-Antibody Conjugate
Authors: Kim Namsoo , Oh Sun Mi , Kim Chong-Tai , Cho Yong Jin
Published: November 2024

C-Reactive protein (CRP), which is an 118 kDa pentameric protein, was secreted by the liver is an important biomarker for coronary disease, hypertension and inflammation. In this study, a method for CRP detection exploiting quantum dot (Qdot)-antibody conjugate was developed according to an indirect-competitive immunosensing protocol. For this purpose, a streptavidin-bound Qdot605 was linked with a separately prepared biotinylated monoclonal antirat CRP antibody to produce a Qdot-antibody conjugate. The immunosensing was performed at 0.1 and 20 nM of the coating antigen and conjugate, respectively. The current method was found very sensitive in CRP detection, judging from the concentration-dependent fluorescence emission.
Isolation and Characterization of Thermophilic Microorganism Producing Starch-hydrolyze Enzyme
Authors: Choi Wonseok , Bai Dong-Hoon
Published: November 2024

A thermophilic microorganism, which is able to hydrolyze starch, was isolated from soil and compost in Korea. It was Gram-positive, rod-shaped, catalase positive, nonmotile, glucose and mannitol fermentative, xylose oxidative, and spore forming microorganism. It also has an ability to hydrolyze casein and gelatin. The color of colony was yellowish white. The sequence of 16S rDNA of strain 2719 showed 99.5% sequence homology with the sequence of 16S rDNA of Bacillus thermoglucosidasius. On the basis of biochemical and physiological properties and phylogenetic analysis, the isolated strain was named as Bacillus thermoglucosidasius 2719.
Changes in Physicochemical Properties of Low Salt Soybean Paste (Doenjang) during Fermentation
Authors: Lee Ju-Yeon , Mok Chulkyoon
Published: November 2024

Changes in physicochemical properties of soybean pastes (Doenjang) of various salt contents (8-14%) during fermentation were investigated to explore the possibility of manufacturing a low salt soybean paste. Titratable acidity (TA) increased and consequently pH decreased with the fermentation time. The rates of TA and pH changes increased as the salt levels decreased. Protein contents remained unchanged and there were no differences among different salt levels. The amino nitrogen contents and the volatile basic nitrogen contents increased with fermentation time and showed higher values at lower salt levels. The reducing sugar contents increased from 6th to 11th week of fermentation, and decreased afterward. No remarkable differences in the reducing sugar contents were observed with respect to salt levels. Shorter fermentation periods were required at reduced salt levels. Appropriate fermentation periods of the 8, 10, 12 and 14% salt containing Doenjang were 2 to 11 weeks, 3 to 12 weeks, 6 to 14 weeks, and 9 to 15 weeks, respectively. Doenjang fermented for shorter period of time at lower salt content showed better sensory quality than that for longer period at higher salt content.
Isolation of 20(S)-Ginsenoside Rg3 and Rg5 from the Puffed Red Ginseng
Authors: An Young-Eun , Cho Jin-Gyeong , Baik Nam-In , Choi Sung-Won , Hur Nam-Yoon , Park Seok-Jun , Kim Byung-Yong , Baik Moo-Yeol
Published: November 2024

Red ginseng tail roots (9.8 g water/100 g sample) were puffed at 7, 8, 9, and 10 kgf/cm2 using a rotational puffing gun. Puffed red ginseng was extracted with 70% ethanol, and the concentrated extract was successively partitioned with diethyl ether, n-butanol and H2O. Two unknown ginsenosides from puffed red ginseng were found at 63 and 65 min of retention time in HPLC chromatogram suggesting that chemical structure of some ginsenosides might be altered during the puffing process. Identification of two unknown compounds was carried out using TLC, HPLC and NMR. Two major compounds were isolated from TLC. According to TLC result, compound I was expected to be the mixture of ginsenosides Rk1 and Rg5, and compound II was expected to be a 20(S)-ginsenoside Rg3. Three compounds were isolated from n-butanol fraction through repeated silica gel and octadecyl silica gel column chromatographies. From the result of 1H- and 13C-NMR data, the chemical structures of unknown compounds were determined as ginsenoside Rg5 and 20(S)-ginsenoside Rg3. Unfortunately, ginsenoside Rk1 could not be separated from ginsenoside-Rg5 in the compound I. It was carefully reexamined using HPLC and confirmed that the last unknown compound was ginsenoside-Rk1.
Comparison on the Extraction Efficiency and Antioxidant Activity of Flavonoid from Citrus Peel by Different Extraction Methods
Authors: Cheigh Chan-Ick , Jung Won-Guen , Chung Eun-Young , Ko Min-Jung , Cho Sang-Woo , Lee Jae-Hwan , Chang Pahn-Shick , Park Young-Seo , Paik Hyun-Dong , Kim Kee-Tae , Chung Myong-Soo
Published: November 2024

The extraction of polyphenol and flavonoid from citrus peel was performed by the ethanol, sugar, hot water (80°C), and subcritical water extraction methods. The maximum yields of total polyphenolic compounds (27.25±1.33 mg QE/g DCP, QE and DCP indicate quercetin equivalent and dried citrus peel, respectively) and flavonoids (7.31±0.41 mg QE/g DCP) were obtained by subcritical water extraction (SWE) with operating conditions of 190°C, 1300 psi, and 10 min. The yields by SWE were over 7.2-, and 8.5-fold higher than those of total polyphenols (3.79±0.73 mg QE/g DCP) and flavonoids (0.86±0.27 mg QE/g DCP) obtained using the ethanol extraction, which showed the highest extraction efficiency among tested conventional methods, respectively. Antioxidant activities of extracts obtained by different methods showed no significant differences. However, the relative antioxidant yield per 1 g dried citrus peel by SWE (190°C, 10 min) was over 9.5-fold higher than that by the ethanol extraction.
Manufacturing of Hemp Seed Flake by Using Extrusion Process
Authors: Tie Jin , Gu Bon-Jae , Ryu Gi-Hyung
Published: November 2024

Proximate composition of whole hemp seed, paste viscosity of whole hemp seed pellets, bulk density, color, compression force, water solubility and absorption index and bowl life of whole hemp seed flakes manufactured by extrusion process were determined to evaluate whole hemp seed as flake additive. Extrusion process conditions were 35% of moisture content and 90, 100 and 110°C of barrel temperature. Content of moisture content, crude protein, crude fat, crude ash from whole hemp seed were 5.67±0.02%, 25.93±0.16%, 28.21±0.56% and 7.70±0.08%, respectively. The pellets hemp seed at 100 or 110°C had higher paste viscosity as compared to those pellet at 90°C. The bulk density values of all hemp seed flakes were between 0.24 to 0.43 g/mL, depending on the barrel temperatures. The hardness of flake increased with decreasing percentage of hemp seed in flakes. An increase in barrel temperature from 90°C to 110°C resulted in increase of WSI and decrease of WAI. The bowl life of hemp seed flakes was increased from 5.8 to 15.5 min with the decrease in percentage of hemp seed. The highest overall quality was showed in flake added with 20% of hemp seed.
Effect of Saururus chinensis Powder Addition on the Quality of Sugar Snap Cookies
Authors: Bae Hyun Joo , Lee Hye Yeon , Lee Jin Hyang , Lee Jun Ho
Published: November 2024

Saururus chinensis powder was added into cookie dough at 5 levels (0%, 1.5%, 3%, 4.5%, and 6%) by partially replacing equivalent amount of wheat flour in cookie formulation, and cookies thus made were evaluated for physicochemical properties and sensory quality by a small semi-trained panel. Thickness and density of cookies increased significantly with increase in Saururus chinensis powder content (p<0.05); however, those of dough were not affected (p>0.05). The pH of both dough and cookies decreased significantly as the level of Saururus chinensis powder increased (p<0.05). Lightness and yellowness decreased significantly as the Saururus chinensis powder content increased while redness increased significantly (p<0.05). Spread factor decreased with the powder addition (p<0.05). Sensory evaluation indicated that samples with higher amount of the powder received higher scores in terms of taste, flavor, and color but not for hardness (p<0.05). Finally, correlation analysis showed that level of Saururus chinensis powder incorporation was well-correlated with most of the physicochemical properties and sensory attributes studied.
Isolation and Identification of Alkalophilic Microorganism Producing Xylanase
Authors: Choi Ji-Hwi , Bai Dong-Hoon
Published: November 2024

An alkalophilic microorganism named DK-2386, which produces xylanase, was isolated from soil of Taejo-mountain, Cheonan-si, Chungnam, Korea. The isolated strain was characterized as Gram-positive, with size of 0.4×2.5 μm, spore forming, anaerobic, catalase positive, possessed with hydrolysis abilities of casein, starch, sodium carboxy methyl cellulose, and xylan, reduction of nitrate to nitrite, resistant against lysozyme, urease positive, and motility positive. The color of culture broth was reddish yellow. The strain DK-2386 was identified as Bacillus agaradhaerens by whole cell fatty-acid composition analysis and 16S rDNA sequence analysis. However, it was not identical to Bacillus agaradhaerens 40952 obtained from the Korean Culture Center of Microorganism in its colour of culture broth. Therefore, we have named the newly isolated strain as Bacillus agaradhaerens DK-2386.
Influence of Ozonated Water and Washing Method Using Ozonated Water for Controlling Food-borne Disease Bacteria
Authors: Park Jeongmi , Shin Han-Seung
Published: November 2024

The efficacy of the ozonated water (0.1, 0.2, 0.4, 0.6, and 1.0 ppm) in reducing the risk of food-borne disease was investigated in this study. After inoculation of Listeria monocytogenes (ATCC 19112), Salmonella enterica subsp. enterica biovar Typhimurium (ATCC 12598), Escherichia coli O157:H7 (ATCC 43890) to lettuce, spinach, and beef, inhibition effect with different washing concentrations, time, and methods with ozonated and tap water were evaluated. As a result, there were 2.16 to 3.85 log CFU/mL reduction in different foods and 7 log CFU/mL reduction on cutting boards after watering with ozonated water. Higher than 0.2 ppm of ozonated water treatment reduced the growth of food-borne disease bacteria with increasing washing time and ozone concentration. These results suggested that the ozonated water treatment effectively improved the microbiological quality and food safety.
Production of Antithrombotic Material Extracted from Auricularia auricular-judae and the Verification of Its Antithrombotic Activity via Animal Test
Authors: Park Young-Seo , Choi Hyuk-Joon
Published: November 2024

Large-scale preparation steps of antithrombotic materials from wood ear mushroom (Auricularia auricular-judae) were established as follows. Grounded dry wood ear mushroom was extracted with 75% ethanol and its precipitate was extracted with 76°C water for 2 hr followed by filter pressing. The filtrate was then concentrated by vacuum and extracted with 80% ethanol, and the resulting precipitate was then freeze-dried. The formula of the product was determined using consumer susceptibility tests as follows; mushroom extract 90.5%, high fructose corn syrup 2.0%, β-cyclodextrin 1.5%, fructo-oligosaccharide 2.0%, pear puree 4.0%. When the packed products were stored at 25, 37, or 45°C for 8 weeks, there were no noticeable changes in water activity, moisture content, pH, and acidity. The viable cell number of total bacteria was slightly increased during the storage period at 25 and 37°C, The total bacteria were not detected in the product when stored at 45°C. When the product was injected intravenously into rat at the level of 1,000 mg/kg, antithrombotic activities such as activated partial thromboplastin time, thrombin time, prothrombin time, and FIB were increased when compared with the control group. When the product was administrated orally into rat at the level of 500 mg/kg, it showed the same antiplatelet activity to aspirin.
Development of Prediction Model for Capsaicinoids Content in Red-Pepper Powder Using Near-Infrared Spectroscopy - Particle Size Effect
Authors: Mo Changyeun , Kang Sukwon , Lee Kangjin , Lim Jong-Guk , Cho Byoung-Kwan , Lee Hyun-Dong
Published: November 2024

In this research, the near-infrared absorption from 1,100-2,300 nm was used to measure the content of capsaicinoids in the red-pepper powder by using the Acousto-optic tunable filters (AOTF) spectrometer with sample plate and sample rotating unit. Non-spicy red-pepper samples from one location (Younggwang-gun. Korea) were mixed with spicy one (var. Chungyang) to make samples separated by particle size (below 0.425 mm, 0.425-0.71 mm, and 0.71- 1.4 mm). The Partial Least Squares Regression (PLSR) model to predict the capsaicinoid content on particle sizes was developed with measured spectra by AOTF spectrometer and used to analyze the amount of capsaicinoids by HPLC. The PLSR Model of red-pepper powder of below 0.425 mm, 0.425-0.71 mm, and 0.71-1.4 mm with cross validation had RV2 = 0.948-0.979 and Standard Error of Prediction (SEP) = 6.56-7.94 mg%. The prediction error of smaller particle size of red-pepper powder was low. The best PLSR model was found in pretreatment of Range Normalization, Standard Normal Variate, and 1st Derivatives of red-pepper powder of below 1.4 mm with cross validation, having RV2 = 0.959 and SEP = 8.82 mg%.
Physicochemical Property Changes of Sweet Potato Starch by Ultra Fine Pulverization
Authors: Kim Hee-Sun , Park Hye-Young , Han Gwi-Jung , Kim Myung-Hwan
Published: November 2024

This study was performed to analyze the effects of ultra fine pulverization (UFP) on the physicochemical properties of sweet potato starch (SPS). The average diameter and specific surface area of the SPS was decreased from 22.94 to 10.25 μm and from 0.879 to 1.909 m2/g throughout UFP, respectively, and the damaged starch content was increased from 13.7 to 99.2%. The pulverized sweet potato starch (PSPS) had higher swelling power, solubility, and transmittance values than the SPS. X-ray diffractograms revealed that the SPS had a C-type pattern, which disappeared in PSPS. The rapid visco analysis (RVA) characteristics, peak viscosity, break down, and set back of SPS ceased to exist in PSPS. According to differential scanning calorimetry (DSC) curves, the peak temperature (Tp) and gelatinization enthalpy (ΔE) of SPS were 71.95°C and 10.40 J/g, respectively, while these remained undetected in PSPS. The enzymatic digestibilities of SPS and PSPS were 61.7 and 84.7%, respectively.
Kinetics and Equilibrium Study on β-Glucosidase under High Hydrostatic Pressure
Authors: Han Jin Young , Lee Seung Ju
Published: November 2024

β-Glucosidase enzyme reaction under high hydrostatic pressure was investigated in terms of physical chemistry. A model substrate (p-nitrophenyl-β-D-glucopyranoside (pNPG)) was used, and the pressure effects on the enzymatic hydrolysis (pNPG→pNP) at 25 MPa, 50 MPa, 75 MPa, and 100 MPa were analyzed. Two parts of the reaction such as kinetic and equilibrium stages were considered for mathematical modelling, and their physicochemical parameters such as forward and inverse reaction constants, equilibrium constant, volume change by pressure, etc. were mathematically modeled. The product concentration increased with pressure, and the two stages of reaction were observed. Prediction models were derived to numerically compute the product concentrations according to reaction time over kinetic to equilibrium stages under high pressure condition. Conclusively, the β-glucosidase enzyme reaction could be activated by pressurization within 100 MPa, and the developed models were very successful in their prediction.