bluuebunny/crossref_metadata_2025 huggingface dataset:
Exposure to Climate Events and Mental Health: Risk and Protective Factors from the California Health Interview Survey
Authors: Zhao Daniel , Epel Elissa , Allen Elaine , Hwong Alison  R.
Published: February 2024

There is increasing awareness of the effects of climate change on mental health, but more work on understanding risk and protective factors is needed. The 2021 California Health Interview Survey included new questions about exposure to extreme weather events and mental health responses. This study aims to identify how individual factors and neighborhood social cohesion are associated with negative mental health effects of exposure to extreme weather events. In this cross-sectional, representative study, we used data from the 2021 California Health Interview Survey to analyze the association between respondent characteristics and negative mental health effects following exposure to extreme weather events. Univariate and multivariate logistic regression models were used, adjusting for individual-level sociodemographics and measures of neighborhood social cohesion. We found that 53% of the sample was affected by climate events (n = 12,955), and of these, 22.8% (n = 2,955) reported a negative impact on their mental health. Respondents who were younger, White, female, college-educated, or living in a rural area were more likely to report adverse mental health effects of climate events for themselves or household members. Individuals who had experienced property damage were much more likely to report negative mental health effects due to climate events [property damage adjusted OR 3.73, 95% CI 2.82-3.76]. This study identifies subgroups that may have higher vulnerability to the mental health effects of climate change events. Future research is needed to develop targeted prevention and outreach interventions these subgroups to build individual- and community-level resilience.
Effects of interfacial debonding on the stability of finitely strained periodic microstructured elastic composites
Authors: Pranno Andrea , Greco Fabrizio , Luciano Raimondo
Published: February 2024

Predicting failure initiation in nonlinear composite materials, often referred to as metamaterials, is a fundamental challenge in nonlinear solid mechanics. Microstructural failure mechanisms encompass fracture, decohesion, cavitation, compression-induced contact, and instabilities, affecting their unconventional static and dynamic performances. To fully take advantage of these materials, especially in extreme applications, it is imperative to predict their nonlinear behavior using reliable, accurate, and computationally efficient numerical methodologies. This study presents an innovative nonlinear homogenization-based theoretical framework for characterizing the failure behavior of periodic reinforced hyperelastic composites induced by reinforcement/matrix decohesion and interaction between contact mechanisms and microscopic instabilities. Debonding and unilateral contact between different phases are incorporated by employing an enhanced cohesive/contact model, which features a special nonlinear interface constitutive law and an accurate contact formulation within the context of finite strain continuum mechanics. The theoretical formulation is demonstrated using periodically layered composites subjected to macroscopic compressive loading conditions along the lamination direction. Numerical results illustrate the way in which debonding phenomena, in conjunction with fiber microbuckling, may influence the critical loads of the examined composite solid. The sensitivity of the results obtained through the proposed contact-cohesive model at finite strain with respect to its implementation is also explored.
Neural processing of speech sounds at premature and term birth: ERPs and MMR between 32 and 42 weeks of gestation
Authors: Urbanec Josef , Chladkova Katerina , Kremlacek Jan
Published: February 2024

Prenatal listening experience reportedly modulates how humans process speech at birth, but little is known about how speech perception develops throughout the perinatal period. The present experiment assessed the neural event-related potentials (ERP) and mismatch responses (MMR) to native vowels in 99 neonates born between 32 and 42 weeks of gestation. The vowels elicited reliable ERPs in newborns whose conception age at time of experiment was at least 36 weeks and 1 day (36+1). The ERPs reflected spectral distinctions between vowel onsets from conception age 36+6 and durational distinctions at vowel offsets from conception age 37+6. Starting at age 40+4, there was evidence of neural discrimination of vowel length, indexed by a negative MMR response. The present findings extend our understanding of the earliest stages of speech perception development in that they pinpoint the ages at which the cortex reliably responds to the phonetic characteristics of individual speech sounds and discriminates a native phoneme contrast. The age at which the brain reliably differentiates vowel onsets coincides with what is considered term age in many countries (37+0 GA). Future studies should investigate to what extent the perinatal maturation of the cortical responses to speech sounds is modulated by the ambient language.
Individualizing approaches to the rehabilitation of children with chronic adenoiditis, taking into account their constitutional differences
Authors:   Ivanovo State Medical Academy, SULTANOV I. S. , BOBOSHKO I. E. ,   Ivanovo State Medical Academy, ZHDANOVA L. A. ,   Ivanovo State Medical Academy
Published: February 2024

The purpose — to reveal the features of the development, course and character of clinical manifestations of chronic adenoiditis in 4–7 y. o. children of various constitutional types. Material and methods. Children aged 4–7 years with a verified diagnosis of chronic adenoiditis were examined; they were divided into groups by constitutional types using the scale of mental activity orientation. The children with the expert assessment of mental activity orientation in the 1–3 interval were referred to the subgroup of «introverts», with 4–6 points — to the subgroup of «centroverts», and with 7–9 — to the subgroup of «extroverts». The sample of children was as follows: extroverts made up 35.9% of the total number of children, introverts — 34.1%, centroverts — 30%. The nature of clinical manifestations, development and course of chronic adenoiditis were assessed with the data from the child’s developmental history, additional parental questionnaire, and examination. Results. In introverts, the debut of chronic adenoiditis was at the age of 3–4 years, the disease duration by this age was about one and a half years, the diagnosis was made earlier than in extroverts, but with a later development of exudative otitis. In introverted children, complaints related to snoring and obstructive sleep apnea syndrome, as well as sound pronunciation disorders, came to the forefront. In extroverted children, chronic adenoiditis debuted at the age of 4–5 years, with the disease duration of about six months, with later diagnosis, but with early formation of exudative otitis. Clinical manifestations in extroverted children were associated with postnasal syndrome combined with nocturnal cough, formation of exudative otitis, frequent purulent otitis media and sharp hearing loss. Conclusion. Differences in the clinical and functional course of chronic adenoiditis in preschool children of various constitutional types should be taken into account in the organization of rehabilitation. This will improve the quality of life of these children, increase the bodily reactive capabilities and the levels of success and social adaptation in educational institutions.
Pathological spinal fractures secondary to diffuse osteoporosis induced by chronic obstructive pulmonary disease
Authors:   TomoGrad Diagnostic Center, CHERKASHINA S. L. , YASINSKAYA A. S. ,   Clinical Emergency Hospital, NOVIKOV A. YU. ,   City Clinical Hospital No. 21, ZUBAIROV V. A. ,   MEDSTANDART National Medical Holding, KHUZHAKHMETOVA A. SH. ,   Clinical Emergency Hospital, GIMALTDINOV A. YA. ,   Clinical Emergency Hospital
Published: February 2024

The article discusses a clinical case of pain in the lower back due to pathological fractures of lumbar spine against the background of severe secondary osteoporosis induced by chronic obstructive pulmonary disease. Timely diagnostic examination and consultations with relevant specialists made it possible to identify the cause of back pain, prescribe medication for pain, prevent pathological spinal fractures associated with osteoporosis, and provide medical rehabilitation.
Using artificial intelligence for diagnosing Parkinson’s disease
Authors:   Republic Consultative and Diagnostics Center for Extrapyramidal Pathology, ZALYALOVA Z. A. , KHASANOV I. A. ,   BRAINPHONE Digital Solutions for Diagnostics of Brain Disorders LLC, KHASANOVA D. M. ,   Republic Consultative and Diagnostics Center for Extrapyramidal Pathology, ILINA G. R. ,   Republic Consultative and Diagnostics Center for Extrapyramidal Pathology, KUTNIKOVA Т. A. ,   Orenburg Regional Clinical Neuropsychiatric Hospital of War Veterans, Center for Extrapyramidal Pathology, PLESHKOVA О. L. ,   AS Neurology LLC, ALIMETOVA Z. R. ,   Kazan State Medical University, GUBAREVA Е. A. ,   Tolyatti City Clinical Hospital No. 5
Published: February 2024

In the article we discuss the features of Parkinson’s disease (PD) diagnostics: the generally accepted clinical criteria, their sensitivity and specificity compared to modern diagnostic methods like a voice diagnostic service for PD based on artificial intelligence technologies. The purpose was to clinically test a prototype of a voice-based PD diagnostic service developed as part of the BRAINPHONE project. Material and methods. 100 patients (a balanced sample) who applied to the Republic Consultative and Diagnostic Center for Extrapyramidal Pathology (Kazan) were included in the unselected cohort clinical study. All patients were first examined by two experienced specialists in Parkinson’s disease and then by a trained neural network. The neural network conclusions options were «Parkinson’s disease cannot be excluded» or «No signs of Parkinson’s disease» (decision threshold 0.5). Results. As a result of testing the service, the following data were obtained: sensitivity — 80%, specificity — 92%. Compared with the generally accepted clinical criteria for diagnosing PD, voice diagnosis using a trained neural network developed within the BRAINPHONE project in this study showed comparable results in sensitivity and better results in specificity.
Health status and quality of life of children with chronic diarrhea
Authors:   Samara State Medical University, PECHKUROV D. V. , TYAZHEVA A. A. ,   Samara State Medical University
Published: February 2024

The purpose — to comprehensively assess the health status of children and adolescents with chronic diarrhea and the impact of chronic diarrhea on quality of life indicators. Material and methods. 466 children were examined. The main group consisted of 240 children with chronic diarrhea aged from 1 month to 18 years (average age 7.3 ± 5.3 years). The comparison group consisted of 226 children of health groups 1-2 without chronic diarrhea (average age 6.9 ± 4.6 years). The exclusion criteria were newborn period, children with chronic pathology during decompensation period, severe somatic pathology. Clinical and anamnestic research methods were used: parents’ questionnaires, anthropometric measurements, system analysis of the child’s medical documentation, general clinical research methods. The quality of life was assessed in children over 2 years of age using the PedsQL4.0™ general questionnaire. Results. Children with chronic diarrhea are 3 times more likely to have allergic pathology, significantly more likely to develop deficient conditions — rickets and latent iron deficiency. When analyzing the degree of resistance in the study groups, it was revealed that children with chronic diarrhea are significantly more likely to have lower body resistance indicators. When assessing the state of the colon microflora, it was found that an excessive growth of opportunistic flora is much more common among the children of the main group. It was also found that children with chronic diarrhea at an early age are most susceptible to a decrease in body mass index. Children of the main group have low indicators of quality of life in terms of physical functioning and experience difficulties in the social sphere in the form of low communication with peers and a decrease in school performance. Conclusion. Children suffering from chronic diarrhea under dispensary supervision need additional correction of trace elements, nutritional support and prevention of acute respiratory diseases. It is important to assess the physical development of children suffering from chronic diarrhea more often for timely diagnosis of abnormalities.
Targeting the Warburg Effect with Glucose Mutation Theory in Post-Cystectomy, Chemotherapy-Contraindicated Cases: A Case Study of a 72-Year-Old Female Treated with Glucosodiene Over a 20-Day Period
Authors: Ahmed Amr , Akl Maher M.
Published: February 2024

This manuscript delves into the intricate landscape of bladder cancer, highlighting the challenges of early detection and the nuanced considerations involved in chemotherapy decision-making based on patient-specific factors. The Maher Akl's groundbreaking Glucose Mutation Theory presents Glucosodiene as a promising breakthrough. The case presentation meticulously details the journey of a 72-year-old woman diagnosed with high-grade papillary urothelial carcinoma, spanning from initial diagnosis to postoperative outcomes. In the face of Bacillus Calmette-Guérin (BCG) therapy failure, Glucosodiene emerges as a safe and reliable alternative, offering a novel and effective treatment avenue, especially in cases where traditional chemotherapy is contraindicated. This approach advocates for Glucosodiene as a primary therapeutic option after the shortcomings of conventional treatments, instilling confidence in its efficacy and safety, particularly for cases deemed ineligible for chemotherapy.
Foundations of Quantum Mechanics Revealed by the Conservation Laws
Authors: Oldani Richard
Published: February 2024

It is often claimed that Einstein is wrong about quantum mechanics. However, when comparisons are made with respect to theoretical foundations rather than experimental results Einstein’s theories are found to be superior. Because he did not complete his own quantum theory its far-reaching, intuitively motivated derivations were never properly appreciated despite the fact that his is the only theory based on a relativistically correct foundation. The development of his arguments reveals that although non-relativistic theory correctly predicts what it is possible to observe (the emissions) with remarkable accuracy it neglects the other half of natural phenomena, that which cannot be observed (the absorptions), thereby violating the conservation of energy. The deficiencies in non-relativistic theory are corrected by applying Hamilton’s principle to derive relativistic equations of motion. This allows quantum mechanical formalism in abstract space to be interpreted as the juxtaposition of particle field geometries in real space. Direct application of the calculus of variations to an electron cycle reveals that the wave function is incomplete because it requires twice the allowable action minimum.
Policies on tax, fees, charges, and land use payments and some recommendations
Authors:   Faculty of Finance and Banking, University of Economics and Law, VNUHCM, Viet Nam, Nguyen Anh Phong , Phan Huy Tam ,   Faculty of Finance and Banking, University of Economics and Law, VNUHCM, Viet Nam, Than Ngoc Minh ,   Faculty of Finance and Banking, University of Economics and Law, VNUHCM, Viet Nam
Published: February 2024

This study was conducted with the primary objective of compiling, analyzing, and commenting on tax policies, fees, and charges related to land. Particularly, these policies will be considered in the light of two important Resolutions: Resolution 19-NQ/TW dated 31/10/2012, and Resolution 18-NQ/TW dated 16/6/2022. These resolutions have set out some basic guidelines for the management and taxation related to land in Vietnam. The study reveals that despite differences in culture, politics, and economy, many countries have effectively implemented tax policies, fees, and charges related to land. These policies often aim to create a significant source of tax revenue, ensure fairness and efficiency in land use, and contribute to sustainable development. To make appropriate policy recommendations, this study scrutinizes current land-related tax, fee, and charge policies in Vietnam, and the status and trends of the real estate and land markets. Data was collected and analyzed from various sources, including official reports, research documents, and reputable online sources. The authors propose several policy recommendations for improving policies related to taxes, fees, and charges on land in the future. These recommendations not only aim to enhance efficiency in tax collection but also focus on providing a reasonable and transparent environment for citizens and businesses while ensuring sustainable and harmonious social development.
Determining the sanctioning of administrative violations in the field of land
Authors:   University of Economics and Law, VNU-HCM, Vu Cao Minh
Published: February 2024

Land is a valuable asset. Land is a condition for human existence and development. The country is increasingly integrating with the world economy when shifting from a centrally planned, centrally subsidized economy to a socialist-oriented market. This requires that the law of the land must also be regularly changed to suit the times. Land law and its related legal system are increasingly being renewed towards timely and effective adjustment of social relations arising in this field. However, the reality shows that the law directly related to the land sector and sanctioning administrative violations in the landing field still has certain limitations and inadequacies. According to the law, the sanctioning of administrative violations in the field of land means that the person with sanctioning competence conducts activities to apply the sanctioning form and remedial measures to the violator. Currently, the work of sanctioning administrative violations in the field of land is strictly and in accordance with the law. Besides the positive aspects, sanctioning administrative violations on construction orders still has many shortcomings and errors. There are many causes, but a common cause is that the regulations on sanctioning administrative violations for this group of behaviors are still unclear. This article analyzes complicated situations in sanctioning administrative violations in the field of land.
Breaking policy on land for Ho Chi Minh City: Some implications from the draft of adjustment of law on land
Authors:   University of Economics and Law, VNUHCM, Vietnam., Truong Hieu Trong
Published: February 2024

For the important role of a major economic and urban center, Ho Chi Minh City needs a distinguished legal, administrative, and economic institution. The advantage of a breakthrough mechanism for specific urban administrations not only creates resilience for HCMC but also brings positive externalities, pulling socio-economic activities of the region and the whole country, quickly approaching the national development goals, and then contributing to the budget. The efficiency after more than five years of implementing Resolution 54/2017/QH14 is a testament to the choice of policy model. However, the rapid growth of economic activities in Ho Chi Minh City once again poses new requirements as well as the need for a new and more breakthrough in this unique optional policy. More importantly, the drafting of a new draft resolution on a new particular sandbox mechanism for HCMC should aim to effectively solve the administrative bottlenecks that are currently arising. Urban governments especially HCMC need to be empowered to be more proactive, more flexible, and more creative. In most of the content that exists a great need for a breakthrough mechanism, the state management of land plays an important role and therefore should be enlisted to find possible solutions while drafting the revised Law on land, which is also being finalized for submission to the National Assembly. The discussion of the article thus proposes resolutions from the content of the draft Resolution on the specific mechanism for Ho Chi Minh City and the relevant provisions in the mentioned draft of the Law on land adjustment.
Land law on real estate auction: Practical application and recommendations
Authors:   University of Economics and Law, VNU HCMC, Vũ Hạnh Dung Kim , Trần Quốc Đạt ,   Masan Group
Published: February 2024

Regulations on real estate auctions in our country have existed for a long time through many amendments to the Land Law, from the 2003 Land Law, the 2013 Land Law, and now the draft of the new Land Law. Legal regulations on real estate auctions have created a solid legal foundation for this activity to take place for years, significantly contributing to socio-economic development. However, the implementation of regulations on real estate auction still faces some obstacles, causing damage to the interests of the state and related entities. In particular, in recent times, there are many disputes arising from real estate auction activities because the provisions of the land law, namely the 2013 Land Law, have not foreseen all situations occurring during the real estate auction process, such as issues related to the financial factor of the investor or the conditions for banning and restricting auction participants, or the issue of deposit and deposit penalty still have some points that are not suitable when applied in practice, etc. By using the synthesis and analysis methods, the article aims to understand the current legal framework on real estate auctions and evaluate the actual application of these regulations in practice, thereby giving a discussion on the overall solution to improve regulations on real estate auctions, contributing to the process of commenting on the draft new Land Law and relevant legal regulations.
Auction of land use rights: Limitations and recommendations
Authors:   University of Economics and Law, VNU-HCM, Viet Nam, Trinh Hien Thuc , Pham Phuc Duong Hoang ,   EPLegal Limited, Nguyen Canh Thi ,   University of Economics and Law, VNU-HCM, Viet Nam
Published: February 2024

The article discusses the policy and legal basis for auctioning land use rights from a doctrinal approach. It primarily focuses on conducting a desk review of statutory rules and regulations related to the specific area of law. Through a review of the current Draft of Land Law, Decree No. 10/2023/ND-CP dated 3 April 2023 (regarding amendments and supplements to several articles of Decrees on instructions for the implementation of the Land Law), and other relevant statutory documents, the article provides recommendations for policymaking and improving the legal framework for the auction of land use rights. The main focus areas for these policy recommendations include identifying cases subject to the auction of land use rights, addressing procurement issues concerning projects with land use, and establishing requirements for auctioning land use rights. These policy recommendations aim to enhance the existing law on the auction of land use rights so that this process can serve as a source of financial revenue for the State, simultaneously ensuring a healthy competitive environment for socio-economic life. Among crucial aspects are the need for a separate decree specifically regulating the auction of land use rights; sufficient rules and regulations to determine the financial capacity and goodwill of participants when they apply to join the auction. Furthermore, careful consideration should be given to replacing the escrow requirement with a bank guarantee.
Land transfer in Vietnam and makes specifically proposals for improvement of the Land law
Authors:   People’s Committee of Nha Be District, Ho Chi Minh City, Vietnam, Le Nguyen Vo Phan
Published: February 2024

The current land law stipulates that there are two mechanisms for land transfer: voluntary land transfer and compulsory land transfer. Voluntary land transfer applies to cases where individuals and organizations reach their own agreement to perform transactions on land use rights. Compulsory land transfer is carried out through the state mechanisms of land acquisition, compensation, and resettlement support. The article analyzes the legal provisions and practices of land transfer in Vietnam. Regarding the voluntary land transfer mechanism, there are still some shortcomings related to the transfer of agricultural land, the problem of land accumulation for agricultural production according to the policy, and large sample field size, as well as the implementation of commercial projects under the voluntary agreement mechanism. For the mechanism of compulsory land transfer through land acquisition, there are also shortcomings, such as the concept of land acquisition for socio-economic development for the benefit of countries or the public interest being unclear, criteria to determine what a project is for the national interest or the public interest has not been established, compensation prices when land recovery is too low compared to market price. Meanwhile, the issue of compensation, support, and resettlement when the State recovers land is still a problem and has not yet ensured the legitimate interests of people whose land is recovered. Finally, the article proposes some recommendations to improve the land law on land transfer.
The Role of Good Corporate Governance on Hospital Performance During Covid-19
Authors:   Universitas Pembangunan Nasional Veteran Yogyakarta, Susanto Heri , Sirait Afni ,   Universitas Pembangunan Nasional Veteran Yogyakarta, Maheresmi Handani ,   Universitas Pembangunan Nasional Veteran Yogyakarta, Zuhrohtun Zuhrohtun ,   Universitas Pembangunan Nasional Veteran Yogyakarta
Published: February 2024

This study focuses on the role of corporate governance in mediating the relationship between the public sector, specifically government-owned hospitals, and financial performance during the Covid-19 pandemic. While there is existing research on corporate governance, there is limited attention given to the public sector and government hospitals in the context of the pandemic. The study highlights government hospitals as they are on the front lines of healthcare services during the pandemic and have experienced a significant influx of patients, particularly in Covid-19 referral hospitals. This has created financial challenges for hospitals, with increased workloads and disrupted cash flows. The objective of this study is to determine the extent to which corporate governance can help manage the financial difficulties faced by government hospitals during the pandemic. The findings of this research are expected to provide valuable insights for the government and hospital managers, aiding in the improvement of corporate governance and financial performance during emergencies such as the Covid-19 pandemic
The Phenomenon Sustainable Competitive Advantage for Alor Island Ecotourism Development: Background Review and Literature Review
Authors:   University of Tribuana Kalabahi, Awang Mesak Y.
Published: February 2024

Various research results regarding ecotourism development have been carried out, but only a little research has been carried out on Alor Island. This results in the literature on this topic not being sufficient as a supporting theory. Therefore, there is a need to understand the resources that contribute to Alor Island’s competitive advantage. The research method used is qualitative with a descriptive approach, through document and literature studies at national and regional levels related to the research theme, namely sustainable ecotourism. This research fills this gap with a Resource-Based View approach. The main objective of this research is to develop a sustainable competitive advantage for ecotourism development on Alor Island. This research reviews the background and previous literature regarding the definition of ecotourism, sustainable tourism development, resource view, dynamic capabilities, and sustainable competitive advantage. To mitigate or prevent sociocultural and environmental harm, it is imperative for all relevant stakeholders, including the government, nongovernmental organizations (NGOs), and local communities, to collectively address the challenges associated with tourism development that leads to adverse impacts
Community Perceptions of the Progo River Sand and Stone Mining Activities in Yogyakarta (Study in the Communities of Sendangagung Village)
Authors:   Universitas Pembangunan Nasional Veteran Yogyakarta, Djaja Sylvia Indah , Sujatmika Sujatmika ,   Universitas Pembangunan Nasional Veteran Yogyakarta, Kusharyanti Kusharyanti ,   Universitas Pembangunan Nasional Veteran Yogyakarta
Published: February 2024

This research aims to determine the perceptions of people living in mining areas regarding the impacts of sand and stone mining activities on the Progo River, Yogyakarta. This research uses a qualitative type with a case study method. Primary data collection was carried out by interviews as well as observations and supporting documents or literature for secondary data. Sand and stone mining activities in the Progo River using heavy equipment by individuals and companies under the pretext of normalizing river flow after the eruption of Mount Merapi based on Decree Number 284 of 2011. This regulation has been misunderstood by various parties, which has given rise to uncontrolled sand mining. One example of mining that caused community rejection occurred in Sendangagung Village, especially the Jomboran, Pundak Wetan and Wiyu areas of Yogyakarta. Researchers found that the community rejected mining because the community had the perception that mining companies took it with heavy equipment without paying attention to the preservation of the land and the environment, which resulted in land degradation, landslides, air pollution and water pollution. Apart from that, the community questions the legitimacy of the government in issuing non-transparent mining permits
Analysis of the Potential and Volatility of Large Chili and Cayenne Chili After Covid-19 in Yogyakarta City
Authors:   Universitas Pembangunan Nasional “Veteran” Yogyakarta, Rahman Ilyasin Aditya , Gracia Siregar Priscilla S. ,   Universitas Pembangunan Nasional “Veteran” Yogyakarta, Suharsih Sri ,   Universitas Pembangunan Nasional “Veteran” Yogyakarta
Published: February 2024

Chili is a category of 10 agricultural commodities and a staple in Indonesia. Price movements that go up and down or fluctuate are certainly a problem in themselves, where chili as a strategic commodity is one of the main determinants of the dynamics of national inflation. Regarding the policy of protecting farmers with restrictions on chili imports, chili stocks become more stable in the country so that local prices can compete with imported products. This observe uses secondary information obtained from the Bank Indonesia website to determine volatility and potential. The cause of this observe is related to the importance of volatility in large chili and cayenne pepper as well as the potential considering that they are the main commodities in agriculture and price projections in October 2023. This study uses quantitative descriptive analytical tools using ARIMA and GARCH time series models to predict time patterns and calculate potential with Location Quotient (LQ) analysis. This research shows volatility in Big Red Chili and Red Cayenne Chili and shows price forecasting that is experiencing a downtrend
INFRASTRUCTURAL SUPPORT OF THE UKRAINIAN LABOR MARKET
Authors:   Kyiv National Economic University named after Vadym Hetman, Atamaniuk Ruslan
Published: February 2024

The article is devoted to the study of the elements of the Ukrainian labor market infrastructure and their role in the context of modern challenges. The relevance of the study is stipulated by the need to understand and support the effective functioning of the labor market in the face of change and instability. The purpose of the article is to develop recommendations aimed at infrastructural support of the labor market as an important condition for adapting to modern challenges, ensuring effective interaction between employers and employees, and developing the Ukrainian labor market in a complex socio-economic context. To achieve this goal, the study solved a number of tasks: defined the concept of "labor market infrastructure", elements of labor market infrastructure and their role in the functioning of the labor market; analyzed the current state of the Ukrainian labor market and negative trends in it; developed recommendations for infrastructure support of the labor market aimed at overcoming them. The study used general scientific methods of cognition: induction and deduction, analysis and synthesis, association and analogy. The study found that a number of negative trends have emerged in the modern labor market, including a shortage of qualified personnel, a mismatch between the geographical location of jobs and labor, the spread of informal employment, and the inappropriate replacement of men by women in certain industries. Overcoming these challenges requires comprehensive infrastructure support for the labor market. This support should include improving vocational education, continuing the reform of employment services, cooperation between employers, government agencies and educational institutions, adapting legislation to labor market dynamics, and integrating innovations into various sectors of the economy to create new employment opportunities. Encouraging flexible forms of employment, such as remote work and freelancing, is crucial. In addition, creating equal conditions for all workers, regardless of gender, age or social status, is imperative to promote the development of a modern labor market. The practical significance of the study lies in the possibility of using its results to develop and implement effective labor market management strategies.
Labour Process Theory: taking stock and looking ahead
Authors: Bagnardi Francesco , Maccarrone Vincenzo
Published: February 2024

L'articolo ricostruisce criticamente la traiettoria del dibattito sulla Labour Process Theory (LPT) da Braverman in poi. Analizza i classici della seconda ondata e i principali fondamenti della cosiddetta ‘core theory' del LPT. Descrive il dibattito suscitato dalla formalizzazione della core theory rispetto al cambiamento delle strutture produttive. Individua alcuni filoni di proficuo dibattito interno, cruciali per l'analisi delle attuali tendenze e trasformazioni del lavoro: il soggetto mancante, il ‘connectivity gap' e il ruolo della tecnologia. Il modo in cui il dibattito interno alla LPT ha affrontato queste questioni è promettente e riafferma la rilevanza della LPT come quadro analitico che rimane cruciale nell'attuale sociologia del lavoro.
Labour Process Theory and the legacy of operaismo. New directions, old problems
Authors: Thompson Paul , Harry Pitts Frederick
Published: February 2024

Simultaneous with the rise of Labour Process Theory (LPT), Italy was the centre of a parallel and prominent theorisation of the labour process in an overlapping intellectual and social context: operaismo. Both have undergone a recent resurgence. This paper provides a critical commentary on the development and claims of operaismo, drawing out some comparisons with LPT. Diversity in the operaist traditions and trajectories are recognised, but the paper focuses on areas where contrasts and conflicts between LPT and aspects of operaismo continue to have salience. There are similarities in the ideas and goals of the two approaches, with both focusing on the dynamic interplay between labour and capital in the hidden abode of production. But operaismo is also an explicitly political project in that it seeks to identify privileged class subjects that can act as the vanguard of broader social transformation. Through an examination of a range of issues concerning changing workplace regimes and how to study them, we find this and other differences have significant analytical, normative and methodological dimensions.
If Transit is Free will Older Adults use it More? A Longitudinal Analysis
Authors: Alousi-Jones Meredith , El-Geneidy Ahmed
Published: February 2024

Free public transit for older adults is a policy often advocated for to increase ridership and reduce their dependence on automobiles. In July 2023 public transit became free on the island of Montréal for older adults (65+). Drawing from longitudinal repeated survey data collected in February 2023 and September 2023 and in-depth interviews collected in November 2023, we study the impacts of free public transit fare policy on older adults’ (65+) frequency of public transit use and satisfaction with service. We did not observe any change in public transit use among those who anticipated increased use in the before period, nor among those who anticipated no change in their use after the implementation of the free fare policy. We observed a positive change in the perception of the convenience of public transit after the implementation of the free fare policy for older adults.
Acoustic Characterization of Shell and Size Engineered Microbubbles
Authors: Rostam Shirazi Niloufar
Published: February 2024

Acoustically activated microbubbles are being used for molecular imaging, targeted drug delivery, and opening the impermeable blood-brain-barrier. However, our limited understanding of microbubble oscillation dynamics can hinder the ability to leverage their full potential in ultrasound applications. In the response to ultrasound, microbubble oscillations can be highly nonlinear, and the presence of a shell adds to the complexity of their oscillatory behavior, but previous models predicting microbubble behavior were based on linear assumptions. The focus of this project is to characterize the physical shell properties of microbubbles using attenuation measurements. The behavior of these microbubbles was observed to be linear at pressures between 4.6-10 kPa and they started to oscillate non-linearly at higher pressures. The estimated shell parameters suggest a higher shell elasticity at lower pressures and higher shell viscosity at higher pressure. Understanding microbubble behavior would help researchers to optimize the use of microbubbles and increase their therapeutic potential.
An Added Dimension for the Cost of Retrofits: A Social Life Cycle Assessment of Single-family House Retrofits
Authors: Shikatani Maya
Published: February 2024

Residential retrofits are a way to make older houses more energy efficient in an effort to decrease emissions. To encourage homeowners to retrofit, governments have implemented financially based programs that have been assessed based on potential to decrease emissions; this leaves the social cost of retrofitting unassessed. The novel application of social life cycle assessment (SLCA) to single-family house archetypes and their retrofit scenarios in Toronto, ON was performed to provide insight into the social and socioeconomic impact of retrofitting on society, occupants and workers. EnergyPlus was used to simulate 26,244 retrofit scenarios and extract energy use, mechanical and geometric data. Based on the partial SLCA, it was found that a maximum of just over 5 years of occupants’ full health were lost, while 4.75 years for society and 16 years for workers were gained by retrofitting. A comparison of recommendations based on SLCA results, heating and cooling energy use intensity (EUI) and cost-benefit showed the need to include social costs in feasibility studies of construction projects. It was found that site specificity in SLCAs go beyond determining thresholds in impact assessment, to influence the breadth of potential impacts that are identified. The importance of audience and stakeholder involvement to increasing the effective use and value of SLCA results was illustrated. Findings contribute to the development of SLCA by providing another instance of application, identification of the difference it could make in decision-making, and the value that unique characteristics like site specificity and stakeholder involvement bring to SLCA results.
Exploring Northern Nigeria's Spice and Condiment Culture
Authors: Bello Oluwasesan M. , Ogbesejana Abiodun B. , Abdulrahman Balkisu , Areguamen Isaac O. , Adeola Segun S. , Sani Suleiman , Aliyu Hamisu , Damaga Sale Shukurana , Ahuchaogu Ahamefula A.
Published: February 2024

Northern Nigerians have a unique viewpoint on spices and condiments that is influenced by their traditional, cultural, and medicinal views. The use of spices and condiments is greatly impacted by the diverse ethnic backgrounds of the region's culinary traditions, including the Fulani and Hausa tribes. Together with their ethnomedicinal qualities, these spices varied functional phytochemicals (such as flavonoids, dietary fibers, polyphenols, and vitamins) and mineral constituents demonstrate their multifarious role in traditional medicine and culinary practices, enhancing the general health of the local populace. In addition to their function as macro- and micronutrients, they are recognized as essential resources for conveying a wide range of biological attributes and medicinal properties. However, modern issues and trends like urbanization, changing agricultural methods, and socioeconomic dynamics have an impact on how spices and condiments are produced, traded, and used, which in turn shapes regional culinary customs and dietary habits. To fully appreciate the rich cultural legacy and culinary traditions of Northern Nigeria, one must comprehend the diverse roles that spices and condiments play in the region which is what this review intends to convey.
An extensive database analysis demonstrates significant increase in platelet quantity in unselected hospitalized patients following treatment with oseltamivir
Authors: Muthiah Chandrasekar , Lian Qinghua , Benz Samantha , Szabo Aniko , Hoffmeister Karin , Botero Juliana Perez , Michaelis Laura C.
Published: February 2024

Not available.
Selective pharmacologic targeting of CTPS1 shows single-agent activity and synergizes with BCL2 inhibition in aggressive mantle cell lymphoma
Authors: Durand Romane , Bellanger Céline , Kervoëlen Charlotte , Tessoulin Benoit , Dousset Christelle , Menoret Emmanuelle , Asnagli Hélène , Parker Andrew , Beer Philip , Pellat-Deceunynck Catherine , Chiron David
Published: February 2024

Innovative therapeutic strategies have emerged over the past decade to improve outcomes for most lymphoma patients. Nevertheless, the aggressive presentation seen in high-risk mantle cell lymphoma (MCL) patients remains an unmet medical need. The highly proliferative cells that characterize these tumors depend on nucleotide synthesis to ensure high DNA replication and RNA synthesis. To take advantage of this vulnerability, STP-B, a clinically available small molecule selectively targeting CTP synthase 1 (CTPS1) has been recently developed. CTPS1 is a key enzyme of the pyrimidine synthesis pathway mediated through its unique ability to provide enough CTP in highly proliferating cells. Herein, we demonstrated that CTPS1 was expressed in all MCL cells, and that its high expression was associated with unfavorable outcomes for patients treated with chemotherapy. Using aggressive MCL models characterized by blastoid morphology, TP53 mutation or polyresistance to targeted therapies, we showed that STP-B was highly effective at nanomolar concentrations in vitro and in vivo, irrespective of these high-risk features. Inhibition of CTPS1 rapidly leads to cell cycle arrest in early S-phase accompanied by inhibition of translation, including of the anti-apoptotic protein MCL1. Consequently, CTPS1 inhibition induced synergistic cell death in combination with the selective BCL2 inhibitor venetoclax, both in vitro and in vivo. Overall, our study identified CTPS1 as a promising target for MCL patients and provided a mechanism-based combination with the BCL2 inhibitor venetoclax for the design of future chemotherapy-free treatment regimens to overcome resistance.
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Authors: Sabol Hayley M. , Ashby Cody , Adhikari Manish , Anloague Aric , Kaur Japneet , Khan Sharmin , Choudhury Samrat Roy , Schinke Carolina , Palmieri Michela , Barnes C. Lowry , Ambrogini Elena , Nookaew Intawat , Delgado-Calle Jesus
Published: February 2024

Multiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to Bortezomib (BOR)-based therapies. Cells of the TME, including osteocytes, upregulated NOTCH3 in MM cells and protected them from apoptosis induced by BOR. NOTCH3 activation (NOTCH3OE) in MM cells decreased BOR anti-MM efficacy and its ability to improve survival in in vivo myeloma models. Molecular analyses revealed that NDMM and PRMM patients with high NOTCH3 exhibit CXCL12 upregulation. TME cells upregulated CXCL12 and activated the CXCR4 pathway in MM cells in a NOTCH3-dependent manner. Moreover, genetic or pharmacologic inhibition of CXCL12 in NOTCH3OE MM cells restored sensitivity to BOR regimes in vitro and in human bones bearing NOTCH3OE MM tumors cultured ex vivo. Our clinical and preclinical data unravel a novel NOTCH3-CXCL12 pro-survival signaling axis in the TME and suggest that osteocytes transmit chemoresistance signals to MM cells.
Defibrotide improves COVID-19-related acute respiratory distress syndrome in myeloma patients after chimeric antigen receptor T-cell treatment without compromising virus-specific and anti-myeloma T-cell responses
Authors: Kocoglu Mehmet H. , Richardson Paul G. , Mo Clifton C. , Rapoport Aaron P. , Atanackovic Djordje
Published: February 2024

Not available.
Ritmo nodal: caso clínico
Authors: Álvarez Cadmilena Diana Gabriela , Merchán Coronel María Graciela , Calderon Guaraca Prissila Banesa
Published: February 2024

Introducción. Los latidos originados en el nódulo aurículo ventricular (AV) o el haz de His, caracterizan al ritmo nodal o ritmo de la unión. Aunque poco frecuente en los adultos, se relaciona con múltiples causas.   Objetivo.  describir los aspectos relacionados con el diagnóstico y tratamiento de esta patología, a fin de establecer elementos novedosos e instructivos de la enfermedad. Metodología. Presentación de caso y revisión de la literatura actualizada, con énfasis en la descripción de las posibles causas relacionadas, el tratamiento y cuidados.  Resultados. mujer de 30 años, con antecedentes conocidos de taquiarritmia, que acude a consulta de seguimiento. La evaluación clínica y ecocardiográfica fueron normales. Mediante la electrocardiografía se diagnosticó una taquicardia por reentrada nodal más ritmo idionodal; que fue tratada con Diltiazem. Conclusión. Para la adecuada aproximación clínica y terapéutica a estos pacientes, es posible lograr que desarrollen su vida normalmente. Para esto es indispensable una historia clínica completa. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos / Clinical cases.