bluuebunny/crossref_metadata_2025 huggingface dataset:
Особливості сезонного росту Pinus sylvestris L. в умовах Правобережного Лісостепу України
Authors: Шлапак В. П. , Адаменко С. А. , Шлапак В. В. , Коваль С. А. , Парубок М. І.
Published: July 2022

Наведено узагальнення наукових досліджень й аналіз експериментальних даних щодо особливостей сезонного росту вегетативних органів P. sylvestris, їх узгодженість з кліматичними умовами Правобережного Лісостепу України. Встановлено, що на механізми, які регулюють ростові процеси, безпосередньо впливає температура повітря. P. sylvestris належить до порід, що розпочинають свою вегетацію рано навесні. Незважаючи на лісорослинні умови, початок росту пагонів спостерігається за підвищення температури повітря приблизно до +8,0 °С. Кульмінація першої хвилі росту, впродовж років досліджень, припадала на червень, коли середньодобова температура повітря піднімалась вище +20,0 °С. У цей час довжина пагона становила 5,5 см. Приблизно із першої декади серпня, інтенсивність приросту пагонів поступово зменшується і до другої декади вересня вони завершують свій ріст. Наші дослідження показали, що ріст хвої розпочинається приблизно на 30-35-ту добу після початку росту пагонів. Дата настання вказаної фази також має певну залежність від температури повітря. За результатами досліджень встановлено, що ріст хвої починається з підвищенням середньодобової температури повітря до +16 °С. Завершення росту хвої відбувається в третій декаді серпня – першій декаді вересня, коли температура повітря нижча +18 °С. У період згасання приросту хвої, який триває 45 діб, формується 28 % маси річного приросту. Загальна тривалість росту хвої становить 105 діб. Період посиленого росту хвої майже в 1,5 раза довший, ніж період згасання, і становить 60 % від загальної тривалості її формування. За цей час утворюється до 73 % маси річного приросту. Впродовж періоду досліджень також відзначено, що інтенсивність росту пагонів від основи крони і до її верхівки поступово збільшується.
Бізнес-моделі ведення лісового господарства на основі надання послуг екосистем: аналіз інноваційних підходів
Authors: Челепіс Т. О. , Соловій І. П.
Published: July 2022

Наведено огляд підходів до бізнес-моделей лісового господарства, інноваційність яких базується на наданні певних послуг екосистем. Для визначення найдоречніших у контексті сприяння досягненню сталого розвитку бізнес-моделей з урахуванням поточної соціально-економічної, екологічної та політичної ситуації проведено дослідження шляхом порівняння відомих на сьогодні прикладів формування бізнес-моделей у сфері лісового господарства на основі надання послуг екосистем. Наголошено на розширених можливостях таких моделей для збереження та багатоцільового використання лісових ресурсів з урахуванням тенденцій їх вичерпності та посилення ролі у забезпеченні суспільства широким колом послуг екосистем. На основі огляду наукової літератури узагальнено розвиток концепції бізнес-моделей у сфері лісового господарства та успішний досвід впровадження інновацій у процесі їх творення. Досліджено шляхи створення доданої вартості у господарській діяльності підприємств сфери лісового господарства, за умови врахування у бізнес-моделях акцентів на викликах ХХІ ст., а саме – змінах клімату та інших антропогенних чинниках в контексті інтенсивного природокористування та зміна ландшафтів. Для вивчення та дослідження обрано три конкретні бізнес-моделі, географічно розташовані на території двох глобальних географічних регіонів – у Північній Америці та Європі: бізнес-моделі постачання харчової продукції та депонування вуглецю розглянуто на прикладі підприємств у Сполучених Штатах Америки, бізнес-модель надання духовно-сакральної культурної послуги екосистем – на основі прикладу підприємства у Швейцарії. Наведено інструменти створення доданої вартості за допомогою трьох основних видів бізнес-моделей на прикладі окремих видів послуг екосистем, забезпечуваних лісами (депонування вуглецю, постачання харчової продукції, духовно-сакральна культурна послуга). Вибір теми пов'язаний із пошуком шляхів включення послуг лісових екосистем у бізнес-моделі підприємств лісового господарства.
Вплив показників оливи в автомобільному двигуні на температури вкладок підшипників колінчастого вала
Authors: Гудз Г. С. , Герис М. І. , Коцюмбас О. Й. , Осташук М. М.
Published: July 2022

Проблема підвищення довговічності двигунів автотранспортних засобів (АТЗ) продовженням ресурсу спряжень деталей та терміном функціонування робочої оливи за часом неухильно зростає. Встановлено, що це актуально за експлуатування АТЗ у складних нестаціонарних умовах, особливо на режимах "пуск-стоп", запиленості, за великих навантажень та низьких швидкостей руху, на автошляхах складного профілю. Перераховані вище умови експлуатування АТЗ призводять до інтенсивного спрацювання деталей й зниження показників якості та погіршення властивостей моторної оливи, що зумовлює зменшення терміну її використання, а отже, збільшення частості заміни останньої й витрат. Окрім цього, інтенсивність відведення теплоти мастилом від поверхонь тертя підшипників двигунів внутрішнього згоряння (ДВЗ) також сприяє підвищенню їхнього ресурсу. Описано технічну характеристику двигуна та методику термометрування вкладок корінних і шатунних підшипників рядного автомобільного двигуна після його припрацювання. З'ясовано розподіл температур за колом вкладок корінних підшипників під час роботи двигуна за зовнішньою швидкісною й навантажувальною характеристиками за різних частот обертання колінчастого вала. Виявлено та побудовано криві зміни температури вкладок від температури оливи за постійного тиску у системі змащування. За результатами цих емпіричних досліджень побудовано математичну модель у вигляді параболічної залежності, яку підтверджено коефіцієнтами кореляції. Також отримано результати випробувань двигуна під час його роботи за зовнішньою швидкісною характеристикою та за різного тиску оливи у системі змащування. Встановлено, що зниження тиску оливи у системі від 0,45 до 0,25 МПа призводить до того, що температура вкладок за колом підшипників під час роботи двигуна за зовнішньою швидкісною характеристикою зростає за частоти 2500 хв-1 – на 4-5 °С, а за 6000 хв-1 – на 12-13 °С. За результатами цих досліджень отримано лінійну модель залежності температури вкладок та оливи за різних тисків у системі на підставі оцінювання її адекватності з допомогою розрахунку коефіцієнтів кореляції.
Artificial Intelligence based Software as Medical Device
Authors: Gade Ahalya , Maddi Ramaiah
Published: July 2022

Even the most basic of artificial intelligence (AI) systems can outperform humans in some milestone tasks. The following article will present the study on how AI-based software can be used in medical devices. The medical industry has seen astounding advances in AI is used extensively in medical sciences and many other sectors. AI-based software as a medical device will deliver safe and effective software functionality that improves the quality of care that patient receives. Along with its benefits, it also faces challenges, including the need for regulation to keep up with the pace of technology.
Symbols to be used in labelling of medical devices
Authors: Dasari Yuktha Lakshmi , Maddi Ramaiah
Published: July 2022

This document specifies different symbols used to express information supplied for a medical device. This document is applicable to symbols used in a broad spectrum of medical devices, that are available globally and to meet different regulatory requirements. These symbols can be used on the medical device itself, on its packaging, or in the accompanying information. The requirements of this document are not intended to apply to symbols specified in other standards.
Review on obsessive-compulsive disorder
Authors: Gorre Venkata Nagaraju , Shaik Karishma , Pothavarapu Tanuja , Kaki Sri Sushma , Shaik Sumayya , Vinodula Sumanth Shekar
Published: July 2022

OCD is a syndrome characterized by obsessions and compulsions, as well as other neuropsychiatric features, and is often associated with primary psychiatric disorders and various neurologic conditions. If severe, OCD can seriously interfere with the patient’s quality of life. The mainstay of treatment is psychotherapy, especially cognitive-behavioural therapy, and pharmacologic interventions, especially selective serotonin reuptake inhibitors (SSRIs). Unfortunately, a significant proportion of patients are refractory to these treatment modalities. A new understanding abuts the neurobiology of OCD has led to novel investigational treatments, especially neuromodulation techniques.
Analysis, classification and quality estimation of hard to recover oils: modern state of the issue
Authors:   Azerbaijan State University of Oil and Industry, Abbasova S.V.
Published: July 2022

The paper provides the outlook of the classification methods for the fields with hard to recover reserves. The methods for solving the problems associated with hard to recover high viscous and heavy oils as well are reviewed. It is shown that one of the major factors for providing high efficiency technologies applied in oil-gas producing fields of Azerbaijan and the capital investment in their development as well is the classification of hard to recover hydrocarbon reserves and the evaluation of complication degree of their production.
On making serviceable and lifting the jacket with serious defects in welding joints
Authors:   “Oil-Gas Scientific Research Project” Institute, Azerbaijan Republic, Hasanov F.G.
Published: July 2022

The paper reviews the issues of evaluation of cover degree of corrosion in steel parts of the jacket in production area being incomplete over twenty years and designed for using in construction of deepwater offshore platform No 7 in Guneshli field, as well as the resistance of structural steel to the deterioration in the stages of occurrence and increase of cracks in welding joints. Despite the appearance of numerous cracks in welding joints of structural steel of the jacket being on shore in the active corrosion medium over the years and the necessity of structural changes, corresponding calculations using traditional methods and state-of-the-art calculation models have been carried out, the jacket made serviceable for operation and its usage as a major facility in construction of No 7 deepwater offshore platform in Guneshli field recommended as well.
Obtaining environment-friendly high-octane gasoline
Authors:   Oil Refinery named after H. Aliyev, Ibrahimov R.G. , Abad-zade Kh.I. ,   Oil Refinery named after H. Aliyev, Kerimov A.N. ,   Oil Refinery named after H. Aliyev, Mejidov R.O. ,   Oil Refinery named after H. Aliyev
Published: July 2022

As a result of theoretic and experimental studies carried out, the compounds have been developed based on the gasoline of catalytic cracking from hydraulic treated vacuum distillation of hard mode with supply of coking gasoline to the upper part of reactor, the reforming gasoline with clear rectification of raw of mild mode, gasoline fraction of -85 оС i.b.p of direct distillation with less toxic octane-increasing additive, as well as oxygenate additive (DIPE). On the basis of obtained compounds, A-92 and A-95 commercial gasolines fully meeting Euro-3 and Euro-4 requirements have been obtained. The content of benzole, aromatic hydrocarbons and sulphur in their composition comprised 1 %, 42.0 % and 10 ppm correspondingly.
Components of diesel fuel and their exposure to the processes of aerobic oxidation
Authors:   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic, Zeynalov E.B. , Taghiyev D.B. ,   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic, Zeynalov S.B. ,   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic, Naghiyev Y.M. ,   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic, Nazarov F.B. ,   ”Karvan-L” Ltd., Huseynov E.R. ,   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic, Huseynov A.B. ,   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic
Published: July 2022

The paper deals with the analysis of the components of diesel fuel and the review of their exposure to the processes of aerobic oxidation. The composition was specified via chromato-mass spectrometry. It was defined that the composition of diesel fuel consists of 55.74 % aliphatic, 5.04 % oleophilic, 12.79 % naphthenic, 8.32 % aromatic, 9.52 % naphteno-aromatic hydrocarbons. Moreover, the fuel contains a small quantity of heteroatomic components, metal-complex compounds, steroids and the products of partial component oxidation as well. Considering the specified composition, the paper reviews the oxidation stability of diesel fuel. It was defined that the diesel fuel almost does not oxidize to 120 оС temperature. Obtained data may be significant for both the professionals dealing with selection of fuel by seasons and petroleum chemistry specialists to obtain valuable compounds using diesel fuel as a raw.
Specification of hydraulic resistance while gas filtration in porous medium in linear and filtration laws
Authors:   “Oil-Gas Scientific Research Project” Institute, Azerbaijan Republic, Hasanov I.R. , Jamalbayov M.A. ,   “Oil-Gas Scientific Research Project” Institute, Azerbaijan Republic
Published: July 2022

As it is known, unlike the formula for hydraulic resistance in reservoir conditions, there are numerous for tube hydraulics. Hydraulic resistance and Reynolds number are important characteristics of flow while gas filtration in porous medium. In this view, their specification is essential while hydrodynamic calculations and modeling of gas filtration in such a medium in reservoir conditions. The formula for the specification of hydraulic resistance coefficient both in linear and binomial filtration law, as well as those for Reynolds number depending on them have been obtained.
Well construction for sand protection of electrical submersible pump
Authors:   SOCAR, Bayramov E.E.
Published: July 2022

The paper deals with the complications associated with the sand production occurring while operation of oil wells with electric submersible pumps. Due to the fact that electrical submersible pumps are related to those, which pump the fluid with high rotating ability under the effect of centrifugal force, the impact of the composition of pumped fluid on its working parts is great. Long-term performance and endurance of the pumps depend on the quantity and granulometric composition of pumped mechanical impurities. The principal protection of electrical submersible pump from sand is based on the scheme according to which the sand and other mechanical impurities in the composition of reservoir product are separated from the fluid in the context of the pumps, and in the form of solution are replaced towards the electrical submersible pump and mixed with pumped fluid in its upper part (at the pump outlet) again. To solve the problem, consistent connection of the pump is offered. The equipment unit consists of the electrical submersible pump, the ejector and sand separator, the operation principle of which is based on the centrifugal force. While starting the electrical submersible pump, the sand separator connected to the engine axis starts rotating as well. Due to the occurred turbulent flow, the sand particles in product acquire centrifugal acceleration and replaced towards production casing. Thus, sucking the fluid cleaned from sand, the electrical submersible pump transfers it to the ejector under the pressure, providing it with the energy necessary for lifting general fluid. The ejector, in its turn, sucking the mixture with sand particles flowing near the electrical submersible pump, mixes it with cleaned fluid and lifts to the surface. The major purpose of offered well scheme is to decrease to the minimum the probability of pump corrosion due to the prevention of physical contact of operating parts of the electrical submersible pump with mechanical impurities.
The modeling of dehydroalkilation of methylcyclohexane via methanol
Authors:   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic, Akhundov A.A. , Alimardanov Kh.M. ,   Institute for Petrochemical Processes, Azerbaijan Republic, Asadov S.M. ,   Institute for Catalysis and Inorganic Chemistry, Azerbaijan Republic
Published: July 2022

Based on the experimental data on the oxidizing dehydroalkilation of methylcyclohexane via methanol, a model of process statics presented in the form of non-linear differential equations has been developed. It is shown that these equations in the partial derivatives with variable coefficients allow to calculate the constants of complicated reactions with the staging mechanism in the presence of hydrocarbons.
First records of Sphingidae, Saturniidae, and Arctiinae (Lepidoptera) in the forests of Polylepis sericea in the Huascarán National Park, Ancash, Peru
Authors: Ancajima Georgette P. , Grados Juan
Published: July 2022

Polylepis forests are home to endemic species and are of great ecological importance. The degradation of these forests, a remarkable and unique biome in the Andean region, might cause severe consequences for the yet poorly studied high-altitude biota. In the context of Global Climate Change and other anthropogenic impacts, such as habitat loss and species invasion, the threat in this region is alarming. Therefore, studies informing about fauna and flora in this area are essential for conservation efforts and political decisions. In this study, we performed an inventory of three nocturnal Lepidoptera taxa (Sphingidae, Saturniidae, and Arctiinae) in Polylepis forests of the Huascarán National Park. The Huascarán National Park is a reserve in the Ancash region in the Andean zone of Peru. The specimens were collected using mixed light traps, from 18:00 to 24:00 hours in November (2015), February (2016), May (2016), and August (2016). We recorded seven species and 155 individuals, corresponding to two species of Sphingidae, one of Saturniidae, and four of Arctiinae. All the species presented are new records for the Huascarán National Park, three are new records for the department of Ancash and one new record for Peru.
Preliminary Report on the Twentieth Excavation Season of the Archaeological Expedition to Wad Ben Naga
Authors: Onderka Pavel , Vrtal Vlastimil
Published: July 2022

The twentieth excavation season of the Archaeological Expedition to Wad Ben Naga primarily focused on the continued excavations of the so-called Isis Temple (WBN 300). The excavation focused on the area in the rear of the temple explored by the Royal Prussian Expedition in 1844. Altogether ten rooms were revealed which allowed the assessment of the whole complex inner disposition of the temple. During the excavation, various pieces of the original cultic equipment were recovered, including pieces of Meroitic statuary and a new lion altar (Altar D). The original locations of the so-called Altars A, B, and C, discovered by the Royal Prussian Expedition, were identified. Outside the so-called Isis Temple, the work focused on uncovering of the Stone Building (WBN 1100) identified next to structure WBN 250.
Copper-catalyzed multicomponent reactions for the efficient synthesis of diverse spirotetrahydrocarbazoles
Authors: Zhan Shao-Cong , Fang Ren-Jie , Sun Jing , Yan Chao-Guo
Published: July 2022

In the presence of copper sulfate, three- or four-component reactions of 2-methylindole, aromatic aldehydes and various cyclic dienophiles in refluxing toluene afforded diverse spirotetrahydrocarbazoles. This reaction is an important development of the Levy reaction by using 2-methylindole to replace ethyl indole-2-acetate and successfully provides facile access to important polysubstituted spiro[carbazole-3,3'-indolines], spiro[carbazole-2,3'-indolines], spiro[carbazole-3,5'-pyrimidines] and spiro[carbazole-3,1'-cycloalkanes] in satisfactory yields and with high diastereoselectivity.
Respected Author, Your research paper has been published successfully. Please find the link below. http://ymerdigital.com/archives/?cpage=6&issId=%202106 Please find the below DOI allocated to your article. 10.37896/YMER21.07/13 OR https://www.doi.org/10.37896/YMER21.07/13 Please find the below attached E- certificates Thanks.
Authors:   Assistant Professor, Department of Computing (Decision and Computing Sciences), Coimbatore Institute of Technology, Coimbatore, Tamil Nadu, India, V Radhamani , D Manju ,   Assistant Professor, Department of Computing (Decision and Computing Sciences), Coimbatore Institute of Technology, Coimbatore, Tamil Nadu, India, M Bobby Prathikshana ,   M. Sc (Integrated) Decision and Computing Sciences, Department of Computing, Coimbatore Institute of Technology, Coimbatore, Tamil Nadu, India, M Javagar ,   M. Sc (Integrated) Decision and Computing Sciences, Department of Computing, Coimbatore Institute of Technology, Coimbatore, Tamil Nadu, India, V Nivetha ,   M. Sc (Integrated) Decision and Computing Sciences, Department of Computing, Coimbatore Institute of Technology, Coimbatore, Tamil Nadu, India, P Rinubha ,   M. Sc (Integrated) Decision and Computing Sciences, Department of Computing, Coimbatore Institute of Technology, Coimbatore, Tamil Nadu, India
Published: July 2022

Since ancient times, gold has been cherished for its value and worth. Back then, gold was primarily used for trading purposes and as a method of remuneration. But now, it is looked upon as an investment and is found to exhibit the wealth of a country. Expensive metals like gold, in critical times, are used to assure the reimbursement of money borrowed as well. Thereby, gold is not only found to behold the rich, but also the poor. During pandemic crises, like the Covid-19, investments on gold in early times, might have a beneficial impact. Hence, predicting gold rates with live data and investing on golds at the right time is quite useful. Various machine learning algorithms like the linear regression, decision tree and random forest have been used to predict the gold rates. By using different algorithms, we've come to a conclusion that the random forest method provides more accurate results. Keywords: Gold rates, prediction, live gold rates, random forest, decision tree, linear regression, predictive analytics
Shoreline Changes and its Impact on Fishing Communities
Authors:   B.Sc. Geography (Hon), Jamia Miillia Islamia University, Jamia Nagar, New Delhi, 110025, Thomas Jose Alfred , V P Dr. Ancy ,   (Corresponding Author), Assistant Professor of Fisheries Economics, School of Industrial Fisheries, Cochin University of Science and Technology, Kochi
Published: July 2022

The fishery system plays a major role as the engine of the coastal economy providing local economic benefits, foreign exchange and employment. Conservation of shoreline area is essential for the existence and well-being of the fishing community. This paper identifies the reasons for shoreline changes and its impact on fishing community. This paper focused on opportunities for the improvement of life of fishing communities. This study will explore the practical concerns among the fishing community and suggest viable measures for making it more effective. The study will also examine the present scope of existing sustainable and resilience measures. The study is based on primary and secondary data. Primary data is available from the fishing communities in Chellanam. Primary data on socio-economic conditions of fishing community will be undertaken by using techniques including semi structured questionnaire, personal interviews and observation methods. The secondary data were collected from the published and unpublished sources of various coastal management Department, Government offices, School of Marine Industrial Fisheries and from various websites of Department of Fisheries, Ministry of Commerce, Ministry of Food Processing Industries and from books, Journals, International and National working papers. Key words: Sustainable Shoreline, Fishing Communities, Coastal Economy, Conservation of Shoreline, Resilience measures
Exhaled nitric oxide in pediatric asthma – Certitudes and perspectives
Authors:   Pediatrics Department, Filantropia Clinical Hospital, University of Medicine and Pharmacy, Craiova, Romania, Diaconu Radu , Stanescu Ligia ,   Pediatrics Department, Filantropia Clinical Hospital, University of Medicine and Pharmacy, Craiova, Romania, Selaru Loredana ,   Filantropia Clinical Hospital, Craiova, Romania
Published: July 2022

The exhaled nitric oxide measurement is one of the methods used in bronchial inflammation assessment. Relatively new, this measurement is non-invasive and more and more accessible, thus even the pediatric patients are able to benefit. The authors are making a brief history followed by the technical details of the measurement and the practical use for the diagnosis and therapy monitoring in bronchial asthma.
Severe complications of a disk battery ingestion (case report)
Authors:   Department of Pediatrics, “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Diaconescu Smaranda , Gimiga Nicoleta ,   Department of Pediatrics, “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Olaru Claudia ,   Department of Pediatrics, “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Lupu Valeriu V. ,   Department of Pediatrics, “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Straticiuc-Ciongradi Iulia ,   Department of Pediatric Surgery “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Aprodu Sandu Gabriel ,   Department of Pediatric Surgery “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Ciubara Anamaria ,   Department of Psychiatry, “Socola” Clinical Psychiatric Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Burlea Marin ,   Department of Pediatrics, “St. Mary” Children’s Emergency Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Certain categories of foreign bodies ingestion in children can cause dangerous and severe complications leading to increased morbidity rates among them. We report a case of disk battery ingestion in a 2 year old girl, with impaction in the upper cervical esophagus, extracted in otolaryngology service but complicated afterwards with tracheo-oesophageal fistula and aspiration pneumonia and by long-term effect with high esophageal stenosis that required endoscopic dilatation.
Colita ulcerativă şi boala Crohn la vârstă pediatrică – tendinţe de evoluţie în România
Authors:   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, România, Becheanu Cristina , Leşanu Gabriela ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, România,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România, Smâdeanu Roxana ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, România,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România, Tincu Iulia ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, România
Published: July 2022

Obiective. În ultimii ani, s-a observat o creştere a numărului de pacienţi diagnosticaţi cu boală inflamatorie intestinală (BII). Ne-am propus să determinăm epidemiologia acestei patologii în rândul populaţiei pediatrice din sudul României, după o perioadă de 10 ani. Material şi metodă. Studiul de faţă este unul retrospectiv, efectuat în cadrul Clinicilor de Gastroenterologie Pediatrică din Bucureşti şi are drept scop identificarea caracteristicilor epidemiologice ale pacienţilor pediatrici care suferă de BII. Am selectat toţi pacienţii aflaţi în evidenţa cu boală inflamatorie intestinală în anul 2011. Un studiu asemănător a fost realizat în urmă cu 10 ani, raportând cazurile aflate în evidenţă în anul 2001, ceea ce a permis o analiză comparativă a datelor obţinute. Rezultate. Am identificat un număr de 74 de cazuri de boală inflamatorie intestinală, în timp ce în anul 2001 au fost menţionate 21 de cazuri. Dintre aceştia, 35 de cazuri au fost reprezentate de boala Crohn (47,29%) şi 39 de pacienţi au fost diagnosticaţi cu colită ulcerativă (52,7%). Studiul precedent a raportat 17 (81%), respectiv 4 (19%) cazuri. Vârsta medie de debut a simptomatologiei este de 10,2 ani în timp ce în 2001 a fost de 13,2 ani. Concluzii. Numărul de cazuri de boală inflamatorie intestinală s-a triplat în ultimii 10 ani. Colita ulcerativă continuă să reprezinte cea mai frecventă formă, însă am observant o creştere a numărului de cazuri de boală Crohn. Deşi cele mai multe cazuri sunt reprezentate de pacienţi cu vârste de peste 10 ani, un procent important este reprezentat de pacienţi cu vârstă sub 5 ani la momentul diagnosticului.
Date antropometrice şi de bioimpedanţă electrică la un grup de pacienţi pediatrici cu leucemii
Authors:   Disciplina Pediatrie I, Universitatea de Medicină şi Farmacie, Târgu-Mureş, România, Chinceşan Mihaela-Ioana ,   Clinica Pediatrie I, Spitalul Clinic Judeţean de Urgenţă, Târgu-Mureş, România, Grama Alina ,   Disciplina Pediatrie I, Universitatea de Medicină şi Farmacie, Târgu-Mureş, România,   Clinica Pediatrie I, Spitalul Clinic Judeţean de Urgenţă, Târgu-Mureş, România, Florian Gabriela ,   Clinica Pediatrie I, Spitalul Clinic Judeţean de Urgenţă, Târgu-Mureş, România, Mărginean Oana ,   Disciplina Pediatrie I, Universitatea de Medicină şi Farmacie, Târgu-Mureş, România,   Clinica Pediatrie I, Spitalul Clinic Judeţean de Urgenţă, Târgu-Mureş, România
Published: July 2022

Introducere. Statusul nutriţional precar este o problemă comună în rândul copiilor cu afecţiuni oncologice. În scopul de a detecta modificările statusului nutriţional şi ale compoziţiei corporale, acest studiu investighează parametrii antropometrici şi compoziţia corporală la pacienţii pediatrici cu leucemie. Material şi metodă. Studiul de tip prospectiv a inclus 33 de pacienţi internaţi în Clinica Pediatrie I Târgu-Mureş împărţiţi în două loturi: lotul I – lot studiu, pacienţi cu leucemie (15 copii) şi lotul II – lot control, pacienţi cu afecţiuni pediatrice (18 copii). S-au măsurat parametrii antropometrici (greutatea – G, înălţimea – I, indicele de masă corporală – BMI, perimetrul mediu al braţului – MUAC şi pliul cutanat tricipital – TST), iar cu ajutorul Analizorului Tanita BC 420 S MA s-a determinat ţesutul gras (FM – kg şi %), ţesutul non-gras (FFM – kg), masa musculară (MM – kg) şi procentul de apă totală din corp (TBW – %). Rezultate. Parametrii antropometrici la lotul de studiu a diferit semnificativ statistic faţă de lotul martor pentru MUAC şi TST (p < 0,05). La copiii din lotul de studiu, FM a fost mult mai redus (14,79 ± 7,14%) comparativ cu lotul martor (21,56 ± 9,06 %) (p = 0,01), iar TBW mai mare (61,84 ± 4,93% versus 57,45 ± 6,64%) (p = 0,02). FFM şi MM nu au diferit statistic la cele două loturi. Concluzii. BIA, alături de antropometria braţelor, este o metodă sensibilă în detectarea alterării compoziţiei corporale la copiii cu malignitate. Comparativ cu lotul de copii cu boli non-maligne, copiii cu leucemii au prezentat alterări mai marcate ale statusului nutriţional.
Bipolar disorder in children: the diagnostical challenge
Authors:   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Radu Dania Andreea , Chirita Roxana ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Untu Ilinca ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Sacuiu Irina ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Lupu Valeriu V. ,   “Gr. T. Popa“ University of Medicine and Pharmacy, „Sf. Maria“ Clinical Pediatrics Hospital, Iasi, Romania, Ciubara Anamaria ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Burlea Lucian Stefan ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

The bipolar disorder becomes more and more frequent in the pediatric field, raising numerous questions regarding the diagnosis. In most cases, the standard criteria of the disease are not fully met in the case of a child, requiring their particularization and a more accurate classification. Also, a central issue is the differentiation and/ or detection of comorbidity with ADHD and conduct disorders in children.
Evaluarea riscului genetic pentru astmul bronşic la copii cu ajutorul softului generalized Multifactor Dimensionality Reduction
Authors:   Departamentul Pediatrie, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Chişinău, Republica Moldova, Cîrstea Olga , Vasilos Liubov ,   Departamentul Pediatrie, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Chişinău, Republica Moldova,   Laboratorul Ştiinţific de Pediatrie, Institutul Mamei şi Copilului, Chişinău, Republica Moldova, Cojocaru Ala ,   Laboratorul Ştiinţific de Pediatrie, Institutul Mamei şi Copilului, Chişinău, Republica Moldova, Savoschin Dorina ,   Laboratorul Ştiinţific de Pediatrie, Institutul Mamei şi Copilului, Chişinău, Republica Moldova
Published: July 2022

Astmul bronşic reprezintă o maladie multifactorială, fiind determinată de numeroase interacţiuni intergenice şi cu factorii de mediu. Metode statistice tradiţionale, utilizate pentru analiza rezultatelor studiilor caz-control, nu permit evaluarea profundă a riscului de dezvoltare a bolii asociat mutaţiior genice. Software-ul GMDR (Generalized Multifactor Dimensionality Reduction, versiunea Beta 0.9) a fost aplicat cu succes în studiile genetice la pacienţii cu cancer, hipertensiune arterială, diabet ş.a. Obiectivul lucrării a constituit utilizarea programului computerizat GMDR în scopul evaluării rolului interacţiunilor intergenice asupra riscului de dezvoltare a astmului bronşic la copiii moldoveni. Material şi metodă. Studiul de tip caz-control a fost realizat pe un lot de 180 de copii: 90 de copii cu astm bronşic şi 90 copii sănătoşi în lotul de control, fi ind comparabili după vârstă şi sex. Software-ul GMDR (versiunea Beta 0.9) a fost utilizat pentru ajustarea covariabilelor discrete şi cantitative. A fost evaluată asocierea riscului de dezvoltare a astmului bronşic cu un şir de polimorfi sme genice: polimorfi smul de deleţie a genelor GSTТ1 şi GSTM1; GSTP1 313 A > G; NAT2 481 C > T, 590 G > A şi 857 G > A; IL-4 -590 C > T; IL-4Rα Arg551Gln; TNFα -308 G > A; repetitivităţile ААТ ale genei NOS1 în intronul 20; CC16 38 G > A. Rezultate. Analiza datelor în studiu cu ajutorul software-ului GMDR a permis identificarea combinaţiei de polimorfisme ale genelor-candidate pentru astmul bronşic (GSTT1+, NAT2 *5-*7/*5-*7, NOS1 <12/>12 şi IL-4 -590 C/C) care majorează de 3,6 ori riscul de dezvoltare a maladiei (OR = 3,61; CI 95% 1,45-8,99; p < 0,01). Concluzii. Rezultatele studiului demonstrează faptul că interacţiunile genice interferează la diferite niveluri ale mecanismelor fiziopatologice de dezvoltare ale astmului bronşic la copii. Analiza modelelor de interacţiune prin aplicarea software-ului GMDR în grupul de studiu indică asocierea riscului de dezvoltare a maladiei în special cu polimorfismul genelor de metabolizare a xenobioticelor şi a genei implicate în producerea oxidului nitric la nivelul mucoasei căilor respiratorii.
Complicaţii severe în cazul unei ingestii accidentale de baterie (prezentare de caz)
Authors:   Disciplina Pediatrie, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Diaconescu Smaranda , Gimiga Nicoleta ,   Disciplina Pediatrie, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Olaru Claudia ,   Disciplina Pediatrie, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Lupu Valeriu V. ,   Disciplina Pediatrie, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Straticiuc-Ciongradi Iulia ,   Disciplina Chirurgie Pediatrică, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Aprodu Sandu Gabriel ,   Disciplina Chirurgie Pediatrică, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Ciubara Anamaria ,   Disciplina Psihiatrie, Spitalul Clinic de Psihiatrie Socola, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Burlea Marin ,   Disciplina Pediatrie, Spitalul Clinic de Urgenţe pentru Copii „Sfânta Maria“, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Ingestia anumitor categorii de corpi străini la copii poate provoca complicaţii periculoase şi grave, ducând la morbiditate crescută în rândul acestora. Prezentăm un caz de ingestie de baterie sub formă de disc la o fetiţă în vârstă de 2 ani, cu impactare la nivelul porţiunii superioare a esofagului cervical, extrasă în serviciul ORL, dar complicată ulterior cu fistulă traheoesofagiană şi pneumonie de aspiraţie, iar pe termen lung cu stenoză esofagiană înaltă ce a necesitat dilataţii endoscopice.
Particularităţi în gastrita micotică la copil
Authors:   Disciplina Pediatrie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Ignat Ancuţa , Diaconescu Smaranda ,   Disciplina Pediatrie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Lupu Valeriu V. ,   Disciplina Pediatrie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Păduraru Gabriela ,   Disciplina Pediatrie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Miron Ingrith ,   Disciplina Pediatrie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Burlea Marin ,   Disciplina Pediatrie, Facultatea de Medicină Generală, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Gastritele micotice rămân un capitol deschis cercetării din cauza cazurilor puţine citate în literatură, a complicaţiilor şi prognosticului incomplet cunoscute, sursă a dificultăţilor terapeutice. Autorii raportează cazul unui copil de sex masculin, în vârstă de 5 ani şi 4 luni, imunocompetent, la care endoscopia digestivă superioară a obiectivat o eso-gastro-duodenită cu Aspergillus.
Particularities of suicidal behavior in children and adolescents
Authors:   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Untu Ilinca , Chirita Roxana ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Diaconescu Smaranda ,   “Gr. T. Popa“ University of Medicine and Pharmacy, “Sf. Maria“ Clinical Pediatrics Hospital, Iasi, Romania, Radu Dania Andreea ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Ciubara Anamaria ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Socola Clinical Psychiatry Hospital, Iasi, Romania, Burlea Lucian Stefan ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

The frequency of suicidal behavior in children and adolescents has increased significantly in recent years, representing a plurifactorial phenomenon, with determining factors in both psychiatric disorders, especially depression and conduct disorders, and also environmental factors including dysfunctional families, academic failure, faulty relationships, including an issue of increasing interest which lies on the border between illness and social factor, represented by the abuse of psychoactive substances. Approaches remain unorganized and inadequate, thus maintaining a real interest in the following subject, child and adolescent suicide, and furthermore raising the issue of improving the means of effective intervention for this situation of global importance.
The impact of the staphylococcus aureus infection on the evolution of children with cystic fibrosis from a regional centre in north-eastern Romania
Authors:   3rd Clinic of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Anton-Paduraru Dana-Teodora , Moscalu Mihaela ,   Department of Medical Informatics and Biostatistics, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Coman Gabriela ,   Laboratory, “Sf. Maria” Children Emergency Hospital, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Florescu Laura ,   Pediatric care, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Trandafir Laura-Mihaela ,   3rd Clinic of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Introduction. Chronic bacterial infections and – often – acute infectious exacerbations are characteristic to the lung disease of the cystic fibrosis (CF). The objective of this study was to identify children with CF and Staphylococcus aureus infection and quantify the impact of this infection on their clinical status. Material and methods. A prospective study was carried out during 3 years on a batch of 37 children with CF registered in the records of the Regional Monitoring Centre of the 3rd Clinic of Pediatrics of Iasi, Romania. In these patients, we searched for the presence of S. aureus, the prevalence of methicillin-resistant S. aureus (MRSA) strains, the impact of the chronic infection with MRSA on the lung function concomitant with the presence of severity elements in CF. Results. 22 of the 37 patients with CF had positive culture for S. Aureus; at 9 of them was isolated MRSA and 5 had chronic infection. The MRSA positive group of patients presented significantly lower values of the FEV1, a more poor nutritional status, severe bronchiectasis, a larger number of pulmonary exacerbations and implicitly hospitalizations, pancreatic insufficiency in most cases and a higher degree of association with the F508del genotype. Conclusions. S. aureus remains an important pathogen in CF. Due to its high pathogeny, S. aureus and especially the MRSA strains can contribute to an unfavourable clinical evolution.
Drug addiction during pregnancy – Risk factor for perinatal infections
Authors:   Neonatology Department, Institute for Mother and Child Care, Polizu Clinical Hospital of Obstetrics and Gynecology, Bucharest, Romania, Broscauncianu Doina
Published: July 2022

Introduction. Neonatal infections are a major causes of neonatal morbidity and mortality. Pregnancy complicated by illicit drug abuse is a risk for perinatal infection. Objective. To assess the incidence of early-onset neonatal sepsis (the first 7 days of life) in newborns from high-risk pregnancies for perinatal infections: the ones affected by drug abuse, without medical assistance versus clinical and fully investigated pregnancies. Material and methods. Retrospective study on newborns from “IOMC – “Gh Polizu” Emergency Clinical Hospital of Obstetrics and Gynaecology”, Bucharest, sorted in two separate groups: one of 25 newborns, from 2005 to 2012, coming from uninvestigated pregnancies in women with illicit drug dependencies and another of 50 newborns from properly managed pregnancies from the clinical and anamnestic point of view, but with known risk factors for perinatal infections. The data has been statistically analyzed (correlation tests: Student T, Fisher exact, chi-square). Results. The incidence of newborns from pregnancies affected by drug abuse was 0,09% in all 28489 newborns, the highest percentage of 0,2% being recorded in 2011. Statistically significant differences between the two groups of newborns with risk factors for perinatal infections (emerged from uninvestigated pregnancies with drug abuse and respectively from investigated pregnancies) were: the age of the mothers – lower in drug addicted mothers (p_value 0,0002), the percentage of congenital infections (p_value 0,00003; OR 0,03; 95%CI) and respectively the mean length of hospital stay-days (p_value0,0180) higher in dug addicted mothers. On the other hand: the delivery by cesarean section (p_value 0,0010), urogenital colonization (p_value 0,0016) were more frequent in newborns from investigated pregnancies. A percent of 22 of all investigated women were positive for Group B Streptococcus and the most frequent type was I b type. The share of perinatal infections among neonatal morbidity was 33% for the newborns from drug addicted mothers and 27% for the newborns from investigated mothers. The incidence of neonatal infections was 52% for the newborns from drug addicted mothers (a risk of 1 in 1,9 cases) and 18% for the newborns from investigated mothers (a risk of 1 in 5,5 cases). Conclusions. Drug addiction during pregnancy represents a high risk factor for perinatal infections due to sexual and blood transmitted diseases associated with lack of hygiene, precarious nutrition and low immunological status and leads to high medical and social costs. The correct medical management of pregnancies, through early diagnosis and treatment of neonatal infections may lower the incidence and the consequences of perinatal infections.
Evaluation of genetic risk factors for childhood asthma using Generalized Multifactor Dimensionality Reduction software
Authors:   Department of Pediatrics, “Nicolae Testemitanu” State Medical and Pharmaceutical University, Chisinau, Republic of Moldova, Cirstea Olga , Vasilos Liubov ,   Department of Pediatrics, “Nicolae Testemitanu” State Medical and Pharmaceutical University, Chisinau, Republic of Moldova,   Scientific Department of Pediatrics, Institute for Maternal and Child Healthcare, Chisinau, Republic of Moldova, Cojocaru Ala ,   Scientific Department of Pediatrics, Institute for Maternal and Child Healthcare, Chisinau, Republic of Moldova, Savoschin Dorina ,   Scientific Department of Pediatrics, Institute for Maternal and Child Healthcare, Chisinau, Republic of Moldova
Published: July 2022

Asthma is a multifactorial disease caused by numerous genetic interrelations and also gene-environment interactions. Traditional statistical methods applied for case-control studies in do not offer the possibility for in-depth analysis of the genetic risk because of the “dimensionality” problem. The Generalized Multifactor Dimensionality Reduction software was successfully applied in genetic studies of cancer, hypertension, diabetes, etc. The aim of our study was to use the GMDR software to analyze the role of genetic interrelations on asthma development in Moldovan children. Materials and methods. The case-control study included 180 children: 90 children with asthma and 90 healthy controls comparable by age and gender. The GMDR software Beta 0,9 was applied to adjust for discrete quantitative data and covariates. Association of genetic polymorphisms (GSTТ1 and GSTM1 gene deletions; GSTP1 313 A > G; NAT2 481 C > T, 590 G > A and 857 G > A; IL-4 -590 C > T, IL-4Rα Arg551Gln; TNFα -308 G > A; (ААТ)n repetitions in intron 20 of the NOS1 gene; and CC16 38 G > A) with the risk of developing asthma was studied. Results. Data analysis using the GMDR method resulted with identification of a combination of four genotypes (GSTT1+, NAT2 *5-*7/*5-*7, NOS1 <12/>12, and IL-4 -590 C/C) that increases by 3.6 folds the risk of childhood asthma development (OR = 3.61; CI 95% 1,45-8,99; p < 0,01). Conclusions. Gene-gene interactions interfere at different levels of pathophysiological mechanisms of childhood asthma development. Analysis of the interaction models generated by the GMDR software based on study data showed a significant association between asthma risk and polymorphisms in two important groups of genes – xenobiotic-metabolizing genes and the gene responsible for nitric oxide synthesis in airway mucosa.