bluuebunny/crossref_metadata_2025 huggingface dataset:
PELAKSANAAN PENGEMBALIAN KERUGIAN KEUANGAN NEGARA (ASSET RECOVERY) DALAM TINDAK PIDANA KORUPSI (Studi Kasus Kejaksaan Tinggi Sumatera Barat)
Authors: Rustam Rustam
Published: February 2019

Kerugian keuangan negara yang ditimbulkan akibat tindak pidana korupsi sungguh luar biasa. Bagaimana keuangan negara yang seharusnya digunakan untuk mensejahterakan rakyatnya, ternyata telah diselewengkan oleh sebagian orang yang tak bertanggungjawab untuk menambah kekayaannya. Metode penelitian ini dilakukan adalah deskriptif yaitu cara penelitian yang menggambarkan secara lengkap dan jelas tentang persoalan yang diteliti dengan pendekatan yuridis sosiologi terhadap penerapan hukum di lapangan oleh penegak hukum. data diperoleh dari dat primer dan data sekunder melalui penelitian lapangan dan penelitian kepustakaan. Hasil penelitian menunjukan bahwa: a) Pelaksanaan pengembalian kerugian keuangan negara di Kejaksaan Tinggi Sumatera Barat lebih cenderung untuk menunggu putusan hakim yang telah berkekuatan hukum tetap, itupun tidak berhasil dilakukan secara maksimal dikarenakan lemahnya sumberdaya manusia dan lemahnya hukum yang berkaitan dengan pengembalian kerugian keuangan negara, b) hambatan dalam pengembalian kerugian keuangan negara antara lain adanya perlawanan dari pihak keluarga tersangka, terpidana tidak sanggup membayar kerugian keuangan negara sebagaimana yang telah disebutkan dalam putusan hakim, dan terpidana meninggal dunia.Kata Kunci : Asset Recovery, Korupsi AbstractThe state financial losses incurred by corruption were extraordinary. How the state finances that should be used for the prosperity of its people, it had been distorted by some people who were not responsible for adding their wealth. The method of this research was descriptive which described completely and clearly about the problem under study with approach of sociology juridical to law enforcement in field by law enforcer. data were obtained from primary data and secondary data through field research and library research. The result of the research shows that: a) The implementation of state financial loss recovery in High Court of West Sumatera is more likely to await the verdict of judge which has a permanent legal force, and even then cannot be done maximally due to weakness of human resources and weakness of law relating to state financial loss return, b) obstacles in the state financial loss recovery was the existence of resistance from the suspect's family, the convicted person can not afford to pay the state financial loss as mentioned in the judge's decision, and the convicted person died. Keywords: Asset Recovery, Corruption
CITRA MEREK SERTA KEPUTUSAN PEMBELIAN PADA CAFE WARUNK UPNORMAL
Authors: Nurjannah Fitria Atni , Firmansyah Egi Aryian
Published: February 2019

Penelitian ini bertujuan menggambarkan citra merek dan keputusan pembelian di Warunk Upnormal cabang Dipatiukur Bandung.Untuk memperoleh data dalam penelitian ini, kami menggunakan instrumen kuesioner yang disebarkan ke 100 responden (konsumen) yang berasal dari kota Bandung dan luar kota Bandung. Hasil penelitian menunjukan bahwa citra merek Warunk Upnormal cabang Dipatiukur,dituangkan kedalam beberapa indikator citra merek,hasilnya baik. Hasil penelitian menunjukan bahwa berkenaan dengan skor sub variabel dari keputusan pembelianhasilnya juga baik. Factor-faktor yang paling berpengaruh dalam keputusan pembelian dalam penelitian ini adlaah faktor pribadi dan faktor psikologis.
ANALISIS PERBANDINGAN LIMA METODE IDENTIFIKASI BIOMETRIK SIDIK JARI DENGAN MENGGUNAKAN MATLAB 7.0
Authors: Ardhani Jayanti , Ismanto Widodo
Published: February 2019

Seiring dengan pesatnya perkembangan teknologi, dibutuhkan sistem yang handal, dimana sistem berdasarkan kepemilikan dan pengetahuan sudah memiliki banyak kekurangan sehingga digunakan sistem biometrik sidik jari dimana password Anda adalah tubuh Anda, tidak perlu diingat ataupun terlupakan. Oleh karena itulah maka penulis melakukan analisis perbandingan lima metode identifikasi biometrik sidik jari dengan menggunakan Matlab 7.0. Tujuannya adalah untuk menghasilkan citra sidik jari yang lebih baik sehingga memudahkan proses identifikasi masalah yang berkaitan dengan proses pencitraan sidik jari.
PENGARUH GAYA KEPEMIMPINAN TERHADAP KEPUASAN KERJA KARYAWAN PADA PT. LION MENTARI AIRLINES
Authors: Herman Herman , Nasruji Nasruji
Published: February 2019

Kepemimpinan dapat dikatakan sebagai cara dari seorang pemimpin, dalam mengarahkan, mendorong, dan mengatur semua unsur-unsur didalam suatu organisasi untuk mewujudkan suatu tujuan yang akan dicapai, sehingga menghasilkan kinerja pegawai yang maksimal. Untuk meraih tujuan tersebut harus di upayakan bagaimana cara seorang pemimpin dapat memberikan dorongan semangat kerja kepada karyawan, agar sasaran maupun tujuan yang di rencanakan secara bersama dapat mencapai target. Selain itu, pemimpin dapat memberikan promosi jabatan bagi karyawan yang berprestasi agar, terciptanya kepuasan kerja karyawan. Dengan memberikan kompensasi, karyawan akan memiliki kepuasan kerja maupun semangat kerja yang tinggi untuk mencapai suatu target. Kepuasan kerja adalah keadaan emosional karyawan di mana terjadi atau pun tidak terjadi titik temu antara nilai balas jasa kerja karyawan dari perusahaan/organisasi dengan tingkat nilai balas jasa yang memang diinginkan oleh karyawan yang bersangkutan. Penelitian dilakukan pada PT. Lion Mentari Airlines. Dalam melakukan penelitian penulis menggunakan metode analisa regresi berganda dan menggunakan koefisien determinasi uji F dan uji T untuk melakukan pengujian hipotesis. Data yang dikumpulkan melalui kuesioner yang dibagikan kepada 50 responden karyawan PT. Lion Mentari Airlines. Dari ketiga variabel independen yang diuji secara individual, tipe kepemimpinan yang paling dominan dalam mempengaruhi kepuasan kerja karyawan adalah tipe pemimpin Otoriter (X2).
PENGARUH KONFLIK KERJA, PENEMPATAN KERJADAN BEBAN KERJA TERHADAP KINERJA KARYAWAN PT. RACER TECHNOLOGY BATAM
Authors: E P Tobing Jon Presly , Zamora Ramon
Published: February 2019

Penelitian ini bertujuan untuk mengetahui secara empiris pengaruh konflik kerja, penempatan kerja dan beban kerja terhadap kinerja karyawan di PT. Racer Technology Batam, baik secara partial maupun simultan. Dengan populasi 130 karyawan dan jumlah sampel sebanyak 57 orang dimana jumlah sample diperoleh berdasarkan rumus Slovin, yang diambil secara teknik sampling purposive. Data yang diperoleh dianalisa menggunakan analisi regresi linear berganda, untuk menguji pegaruh konflik kerja, penempatan kerja dan beban kerja terhadap kinerja karyawan. Hasil Uji t konflik kerja tidak ada pengaruh signifikan terhadap kinerja 0.714>α 0.05 penempatan kerja terdapat pengaruh positif signifikan 0.037<α0.05, beban kerja terdapat pengaruh positif signifikan 0.011<α 0.05). Uji f secara simultan terdapat pengaruh positif signifikan antara variabel independen dengan dependen 9,819>F table 2,87 sig 0,000b artinya bahwa dengan adanya konflik kerja yang positif yang terjadi di lingkungan kerja dapat meningkatkan kinerja karyawan, begitu juga dengan penempatan kerja dan beban kerja yang sesuai terhadap keahlian dan kemampuan disetiap karyawan maka akan dapat meningkatkan kinerja karyawan PT. Racer Technology Batam.
DRUGS DEVELOPED AT «ARC BASS» WITH M.D. MASHKOVSKII LEAD (REVIEW)
Authors: Skachilova S. Ya. , Ermakova G. A. , Zheltukhin N. K. , Zueva E. F. , Davydova N. K.
Published: February 2019

Introduction. There are presented data on drugs development with M.D. Mashkovskii lead. There are given materials on drugs belonging to important pharmacotherapeutic groups of drugs such as generic and original drugs. Original syntheses of famous generic drugs and improved industrial technologies have been developed. The attention is paid to high quality of produced drugs. More than 200 new molecules were synthesized while developing original structures of nitrobenzamide derivatives. The studies of pharmacological and toxicological characteristics have helped to choose and create original antiarrhythmic nibentan and niferidyl. The drugs are registered in the Ministry of Healthcare of the Russian Federation and included in essential drugs list. Text. VNIKHFI branch called today VNC BAV founded in 1966. M.D. Mashkovskii offered that creation to expand scientific and experimental base of drugs development. It continues to research and develop new drugs including syntheses of original molecules, developing of industrial technology, and preclinical research of pharmacological activities, drug safety, and toxicology. Original synthesis schemes are described shortly in the article. Industrial technologies of pharmacopoeial substance synthesis are developed out of these schemes such as γ-butyric acid, dopamine, analgin for injection, and original drugs nibentan – ((RS) N-[5-(diethylamino)-1-phenylpentyl]-4-nitrobenzamide hydrochloride), niferidyl – N-1-[(4-fluorophenyl)- 2-(1-ethyl-4-piperidyl)ethyl]-4-nitrobenzamide hydrochloride. The release of developed drugs to the national industrial production is specially noted. Conclusion. M.D. Mashkovskii always supported national drugs development by submitting valuable offers, paying constant attention to scientific research, quality of drugs, and drugs production in industrial quantities for securing national healthcare with national drugs.
PROVIDING A COMFORTABLE LIFE ACTIVITY IN THE ARCTIC: PROBLEMS AND CHALLENGES
Authors: Pavlenko V I , Kutsenko S Yu
Published: February 2019

The article contains reasoned proposals on solving the most important problems of perspective development of the Arctic zone territories of the Russian Federation (Russian Arctic) - the consolidation of the population as the main productive force for implementation of the objectives of the state policy of the Russian Federation in the Arctic and the Strategy for socio-economic development of the Russian Arctic and ensuring national security up to 2020. Above mentioned documents as well as the State program of socio-economic development of the Russian Arctic up to 2020 are aimed at achieving a high indicators of a macroregion development, including science and technology development, improvement of the effectiveness of resources utilization of the Arctic zone and continental shelf of the Russian Federation in the Arctic and efficiency improvement of the state management of socio-economic development of the Arctic zone and the quality of life of the population of the Arctic zone. The implementation of the state program should create conditions for accelerated socio-economic development of the Arctic zone, the achievement of the strategic interests and national security of Russia in the Arctic. Among the main tools of its implementation is the creation of economic growth points - index zones. It is obvious that to achieve ambitious aims in production sphere it is necessary to relay on the labour resources of appropriate magnitude and professional training. However, the statistical information analysis on dynamics and factors changes in the population base of subjects of federation and the Arctic municipal formations allowed to detect a systematic outflow of labour resources of the macroregion during the last 10 years. Only in 2015 it amounted 22 835 people of working age. Sociological surveys allowed to discover the main reasons for sustainable migration from the Russian Arctic areas. They are: reduction of labor application area and extreme dissatisfaction with the living conditions (quality of housing and lack of opportunities to improve housing conditions, low level of social sphere development). The criteria for "comfortable living", is at a forefront of the population migration from even large settlements - index zones of the Arctic development.
Ergology of Western Polissian folk reed pipes
Authors:   Mykola Lysenko Lviv National Music Academy, Yarmola Victoriya
Published: February 2019

In the publication, a technological system of traditional whistling reed pipes produced by folk artists, widespread in Western Polissia, is revealed for the first time in a step-by-step process. The proposed exploration is based on its expeditionary records and material collected by various folklorists and employ- ees of Kyiv and Lviv research institutions, as well as some literary sources. 131 The existence of three types of nozzle instruments, the names of which correspond to the methods of their production: a pipe made from bark, a vykrutka and kolianka are established. Western Polissian folk reed pipes belong to the type of longitudinal whis- tle flutes with an internal cleft formed by the insertion of the whistling device at the upper end of the tube, and with holes placed on the front, sometimes on the back of the instrument. Whistle airphones have specific production features, according to the age group of masters: shepherd children, teens and adults. The easiest to manufacture among the discovered pipe instruments are ones made of bark, which had been previously removed from the branches of bush trees. In the process of removing the bark shepherds told special spells, which were recorded by the author on the researched area. The following two types of tools were made of wood: a kolianka in the form of a longitudinal splitting of the branch into two equal parts, a vykrutka - a screwing out the core of pine wood, which required a masters knowledge of certain empirical and professional skills. The folk pipe instruments played the role of a musical instrument, which corresponded to the individual artistic and aesthetic test of the flute maker and served as an integral part of the Polisian shepherd's everyday life
A relação entre maternidade e mercado de trabalho: Um estudo sob a perspectiva de uma mãe trabalhadora
Authors: Julião José Rogério Silva , Souza Anne Biatriz do Nascimento Silva , Nascimento Tomaz Técio da Silva , Medeiros Simone Dantas Rosendo de , André Alana Dantas , Oliveira Sérgio Eduardo Medeiros de , Nascimento Daniel Beserra do , Sousa Ricaelly Lúcia Alves da Silva , Araújo Matheus Italo Batista Gomes de , Brito Max Leandro de Araújo
Published: February 2019

O estudo tem por objetivo entender a relação entre maternidade e mercado de trabalho sob a perspectiva de uma mãe trabalhadora. Desse modo, foi usado um questionário qualitativo realizado através de um aplicativo de mensagens instantâneas com uma estagiária de uma instituição de ensino federal que é mãe de três filhos e tem sua rotina de trabalho diária conciliada com o cuidado das crianças. Este estudo revelou que a volta à rotina de trabalho tendo crianças pequenas que dependiam dela foi uma das principais dificuldades, citando como principal delas o fato de não estarem sendo tão bem cuidadas e educadas quanto a própria cuidaria ou educaria. Foi citada como interferências dos filhos já ter precisado faltar ao trabalho por eles adoecerem ou precisarem ir ao médico, nesses casos os chefes aceitam, mas não gostam. Portanto, o estudo aponta que a relação entre maternidade e mercado de trabalho sob a perspectiva de uma mãe trabalhadora é, apesar de difícil, possível, entretanto requer um diálogo da trabalhadora com a instituição e a compreensão por parte da organização.
Bioactivities of Water Extract and Essential Oil from the Mace of Myristica fragrans Houtt
Authors: Widodo Santoso Adit , Simamora Adelina , Simamora Adelina , Herawan Timotius Kris , Herawan Timotius Kris
Published: February 2019

Masyarakat Indonesia telah sejak lama memanfaatkan M.fragrans H. (pala) sebagai rempah-rempah dan penambah aroma pada makanan dan minuman. Secara tradisi, M.fragrans banyak dimanfaatkan untuk pengobatan berbagai kondisi medis, termasuk diabetes mellitus. Studi ini bertujuan untuk menguji bioaktivitas fuli dari M.fragrans, dengan menguji aktivitas antidiabetic, antioksidan, dan antibakteri. Ekstrak air (EA) dan minyak atsiri (MA) diuji efeknya terhadap enzim ?-glukosidase secara in vitro dan terhadap radikal DPPH. Untuk kedua uji digunakan senyawaan standard sebagai pembanding. Kedua ekstrak juga diuji aktivitas  antibakterinya terhadap enam jenis bakteri dengan metode difusi sumur. Kadar fenolik total EA lebih tinggi dibandingkan MA (47.84 dan 37.21mg GAE/100g berat kering), demikian juga dengan kadar flavonoid total EA (215.36 dan 30.12mg RE/100g berat kering). Kedua ekstrak memperlihatkan aktivitas penghambatan ?-glukosidase yang baik, dimana EA memiliki aktivitas yang lebih kuat dibandingkan dengan MA (IC50=1.86 dan 8.15mg/ml). Sejalan dengan hal itu, EA juga memperlihatkan aktivitas penghambatan radikal yang lebih kuat dibandingkan dengan MA (IC50=1.51 dan 4.59mg/ml). Berdasarkan metode difusi sumur, hanya MA terdeteksi memiliki aktivitas antibakteri dengan zona inhibisi 1.03–1.30mm. Inhibisi terbesar diamati terhadap Staphylococcus mutans. Hasil penelitian mengindikasikan adanya bioaktivitas ekstrak air dan minyak atisiri dari fuli, sehingga dapat dikembangkan potensinya sebagai agen antidiabetic dan antioksidan
IDENTIFIKASI POTENSI PERKEMBANGAN EKONOMI WILAYAH KABUPATEN SLEMAN DALAM KONTEKS URBAN-RURAL LINKAGE
Authors: Sakarov Ogi Dani
Published: February 2019

Polarisasi desa-kota telah menjadi fenomena kewilayahan hampir di semua negara berkembang di seluruh dunia. Hal ini disebabkan oleh ekspansi perkembangan aktivitas kota baik spasial maupun non spasial dimana dalam proses perkembangannya selalu melibatkan wilayah sekitar. Yang menjadi permasalahan adalah sering munculnya back-wash effect, dimana peran kota atas desa dalam proses perkembangan ini sering kali menjadikan desa sebagai penyangga dan pemasok sumber daya pertumbuhan kota, sehingga kota lebih berperan sebagai parasit yang mengekploitasi sumberdaya desa untuk stimulan pertumbuhannya. Penelitian ini mengidentifikasi kecenderungan perkembangan ekonomi wilayah Kabupaten Sleman sehingga dapat teridentifikasi potensi perkembangannya. Penelitian ini menggunakan pendekatan deduktif, dan metode deskriptif kualitatif dan kuantitatif dengan teknik analisis sector basis (location quotient) dan shift share. Dari hasil analisis sektor basis dapat dilihat bahwa sektor-sektor yang merupakan ciri khas sektor ekonomi perdesaan sebagian besar bukan merupakan sektor basis, seperti pertanian, perkebunan, perikanan, pertambangan dan penggalian, perdagangan besar dan eceran. Sedangkan, sektor yang menjadi basis aktivitas ekonomi wilayah cenderung menunjang proses urbanisasi, seperti real estat, konstruksi, industry dan lain-lain. Begitu juga yang diperlihatkan oleh hasil analisis kinerja ekonomi wilayah melalui analisis shift-share, bahwa sector-sektor khas masyarakat perdesaan memiliki ritme pertumbuhan yang lambat dan tidak memiliki daya saing. Kata kunci: potensi ekonomi, hubungan desa-kota, sektor basis, kinerja ekonomi wilayah
Differences in the legal regulation of the activities of sexual minorities in Europe and Russia
Authors: Makhmutova M. , Cherenkov A. ,   Kuban State Agrarian University
Published: February 2019

This article provides a comparative analysis of the situation of sexual minorities and their legal rights in Europe, the USA and Russia, as well as their differences, and the attitude of society to people of non-traditional orientation. In addition, the article considered the main problem of modern society is the inability of people to perceive non-traditional relations in military service, in employment at work and much more. Even many liberal countries still do not fully approve of this kind of relationship. Many same-sex couples are prohibited from adopting children, and there are real problems in the field of inheritance law. The article addressed the problem of discrimination of these relations in Russia. This article also examined court practice regarding the underreporting of the rights of sexual minorities.
Conflict settlement of labor relations complicated by a foreign element: problems and prospects
Authors: Tanasienko I. , Negoda N. ,   Kuban State Agrarian University
Published: February 2019

The selected research topic is relevant, since the rapid growth of labor migration at the international level with the use of foreign workers forms relations that are regulated by the rules of private international law, the main content of which is reduced to the conflict of laws problem and its resolution. Today, the particularly important issue of the choice of law to be applied to relations with a foreign element is solved with the help of conflict of laws rules containing the principles for the consideration of controversial legal situations and the criteria for choosing the rules for their regulation. Labor law of any state is a complexly formed structure consisting of private and public elements of law. Consider the norms of the Civil and Labor Codes of the Russian Federation, which relate to the main provisions of private international law, identify problems and offer the most effective ways to solve existing problems.
Incorporando un plan de Vida Saludable en la Terapia Familiar Conductual: Ejemplificando un Caso Clínico de una Mujer con historial de Violencia Doméstica, Negligencia Infantil, Abuso de Drogas y Obesidad
Authors: LaPota Holly B. , Donohue Brad , Warren Cortney S. , Gonzalez-Bueno Arianna , Allen Daniel N. , Aguilera Arévalo Humberto Emilio
Published: February 2019

Las mujeres reportadas a las agencias de servicios de protección infantil, con frecuencia presentan problemas que interfieren con la salud y el bienestar de ellas y de sus hijos. Los programas de intervención conductual parecen ser eficaces en el manejo de problemas coexistentes como: la violencia doméstica y el abuso de drogas. Sin embargo, los tratamientos cuya eficacia ya ha sido demostrada en ocasiones anteriores, rara vez se han puesto en práctica en casos clínicos complicados, sobre todo en los centros de asistencia a menores. Por lo tanto, en este caso clínico, se describe el proceso de adaptación de un tratamiento eficaz para ayudar a controlar los problemas coexistentes de salud de una mujer acusada de negligencia infantil y abuso de drogas. Al finalizar el tratamiento, la participante informó sobre la mejoría en sus relaciones familiares, sobre su consumo de drogas y la negligencia infantil; aunque otros resultados relacionados con su salud no quedaron completamente claros. Gran parte de las mejorías se mantuvieron hasta 4 meses  después de haber concluido el tratamiento. Antes de implementar cada fase del tratamiento, discutimos los  contextos de la comunidad, aumentando así la probabilidad de obtener resultados positivos y respetando la integridad y el ajuste del tratamiento estándar para evitar que se presenten problemas en un futuro.Esta investigación se financió gracias a una subvención del Instituto Nacional de Drogodependencia (1R01DA020548-01A1) otorgada a Brad Donohue. Los autores desean agradecer a Sally K. Miller, PhD, APN, FAANP y Profesora Asociada de la Escuela de Enfermería de La Universidad de Nevada Las Vegas, por el examen físico inicial que se llevó a cabo en el domicilio de la participante de este proyecto.
Terapia Familiar con personas afectadas por el VIH/SIDA como parte de un modelo interdisciplinar
Authors: Oropeza Ismael Fernando Díaz
Published: February 2019

El modelo de intervención multidisciplinario comprende la Terapia Familiar con personas que viven con VIH/SIDA y sus  familias. Sus fundamentos teóricos se encuentran en la Terapia Médica Familiar, la perspectiva biopsicosocial y sistémica. En la práctica clínica se combinan ideas de la terapia colaborativa, narrativa, de construcción de soluciones y el equipo reflexivo. Como resultados, se ha conseguido que las familias normalicen el impacto de la enfermedad, se cogeneren posibilidades como el fortalecimiento  de su capacidad para afrontar los problemas relativos a la enfermedad a través de la agencia, comunión, empoderamiento, normalización, el reencuadre y la movilización de recursos de la familia.
Estereotipos Masculinos en la Relación de Pareja
Authors: Toca Isabel García , Carreta Fernanda Nader
Published: February 2019

El objetivo del estudio es conocer la actitud de los hombres en la actualidad acerca de los estereotipos impuestos por la sociedad dentro de la relación de pareja. La escala de medición que se utilizó consta de 51 reactivos divididos en cinco familias, abarcando hombría, poder, demostración de sentimientos, expectativas dentro de la relación de pareja y pareja en sociedad; el instrumento se realizó con una escala tipo Likert, y fue validado por los tres criterios de discriminación,  confiabilidad y validez de contenido. Se aplicó el instrumento a hombres elegidos de manera no aleatoria. Los resultados indican que en la actualidad los hombres siguen preocupándose por cumplir con los estereotipos que se les imponen dentro de una relación de pareja. Dentro de esto se puede ver que cada vez va disminuyendo esta situación pero a paso muy lento y poco significativo.
1001 Inventions – en historisk aha-upplevelse
Authors: Zouagui Sofia
Published: February 2019

En av de senaste årens mest framgångsrika internationella vandringsutställningar visas nu på Värmlands Museum. Utställningen ”1001 Inventions” synliggör muslimers bidrag till den västerländska civilisationen och är därför ett viktigt redskap i strävan att förändra en felaktig historieskrivning.
Ordförrådets betydelse för läsning
Authors: Wiklund Christina
Published: February 2019

Vårt samhälle ställer stora och varierade krav på individers språkliga och skriftspråkliga färdigheter. Det är en nödvändighet att ha god språk- läs - och skrivförmåga, att vara litterat. En viktig del i att vara litterat innebär att förstå läst text.
Specialpedagogiska resurser i de svenska gymnasieskolorna: en totalundersökning
Authors: Ramberg Joacim
Published: February 2019

Förekomsten och tillgängligheten av specialpedagogiska resurser har undersökts på Sveriges samtliga gymnasieskolor i en aktuell forskningsstudie. Datainsamlingen skedde i januari-mars 2011 och publicerades sommaren 2013. Utöver en nationell beskrivning av specialpedagogiska resurser har olika grupper av skolor jämförts, framförallt kommunala (391 st) och fristående (357 st). Denna text avser att sammanfatta den studien.
Ungdomar som utmanar skolan - Komplexa sammanhang kräver komplexa lösningar
Authors: Severinsson Susanne
Published: February 2019

Synen på ungdomar från social utsatta miljöer styr vad som ses som möjligt och eftersträvansvärt vad gäller deras utbildning. Vi förenklar ofta en komplex problemsituation för att klara av att skapa förståelse av ett visst fenomen och goda intentioner kan skapa hinder för dessa ungdomars skolgång, skriver Susanne Severinsson.
Att återerövra ett kungadöme
Authors: Steneby Kalle
Published: February 2019

Kung Erik sitter på sin tron och spejar ut över församlingen som kommit för att beskåda hans verk. Han vilar sin nöjda och intresserade blick på människorna som står framför honom. En efter en kommer de fram för att ge honom sina ovationer och lämna en gåva. Han skakar hand med alla och ler ett innerligt leende mot var och en. Hans familj är där, hans vänner och hans lärare. I samma stund går det upp för honom att han just återerövrat sitt kungadöme.
På riktigt viktigt - projektinriktat arbete på förskolan
Authors: Hedin Sofia
Published: February 2019

En femårig pojke på förskolan Kakburken i Ryd, har nyss agerat pressfotograf under kungaparets besök i området och blir intervjuad av TV4. Han svarar med allvar och eftertänksamhet på reporterns frågor om varför projektet Perspektiv, som förskolan arbetat med under året, har varit så roligt. - För det är på riktigt viktigt.
Att administrera övergångar: En analys av Skolverkets stödmaterial om övergångar i skolan
Authors: Lago Lina , Simonsson Maria
Published: February 2019

Vilken kunskap finns tillgänglig för att underlätta skolans arbete med barns övergångar och vilket fokus har denna information? Vi har analyserat Skolverkets stödmaterial om övergångar för att se vilka riktlinjer som verksamheterna har att förhålla sig till. Kontinuitet framstår som önskvärt och råden handlar i hög utsträckning om hur skolan och förskolan ska arbeta med att skapa rutiner för detta, men också om vad det är för typ av information som ska överlämnas.
Pedagogers tankar om naturvetenskap i förskolan
Authors: Berggren Helene , Blixt Petra
Published: February 2019

Hur arbetar pedagoger på fältet med naturvetenskap efter den reviderade läroplanen för förskolan? Vad gör de för att ta vara på barnens nyfikenhet i naturkunskapsfrågor? Vilka möjligheter och hinder finns? Vi frågade åtta pedagoger på fyra olika förskolor för att söka svaren på dessa frågor.
The Commitment of Packaging Industry in the Framework of the European Strategy for Plastics in a Circular Economy
Authors: Foschi Eleonora , Bonoli Alessandra
Published: February 2019

European Commission is strongly committed into issues related to plastic materials production and plastic waste management. While the Circular Economy Package has set targets generally referred to recycling rates, the European Strategy for plastics in a circular economy (and related action plan), fosters sustainability along the entire plastic value chain: from primary producers to converters, brand owners and retailers to waste collectors and recyclers. The Directive on the reduction of the impact of certain plastic products on the environment (more commonly known as Directive on Single-Use-Plastics, waiting for publication in the Official Journal of the European Union) rules targets on ten plastic products most often found as littering on global beaches, directly affecting plastic industry and, consequently, market. Policy makers and industrial stakeholders are called upon to collaborate. The article aims to illustrate interactions between European Commission and all plastic value chain stakeholders on implementing measures to reach ambitious targets pursued by the recent European policy. The study shows how European Commission has robustly worked to regulate production and consumption patterns on plastic carrier bags and packaging (including food packaging) thus facilitating the achievement of specific targets provided by the recent Directive. However, additional provisions concerning market restriction have been introduced; industrial stakeholders carried on a prompt response by promoting the creation of alliances, join venture and association, as well as a more integrated plastic value chain. On the base of this purpose, a virtuous example of a closed supply chain is presented.
Water Jacket Systems for Temperature Control of Petri Dish Cell Culture Chambers
Authors: Uharek Samira , Baratchi Sara , Zhu Jiu Yang , Alshehri Majed Ali , Mitchell Arnan , Rebner Karsten , Karnutsch Christian , Khoshmanesh Khashayar
Published: February 2019

Water jacket systems are routinely used to control the temperature of Petri dish cell culture chambers. Despite their widespread use, the thermal characteristics of such systems have not been fully investigated. In this study, we conducted a comprehensive set of theoretical, numerical and experimental analyses to investigate the thermal characteristics of Petri dish chambers under stable and transient conditions. In particular, we investigated the temperature gradient along the radial axis of the Petri dish under stable conditions, and the transition period under transient conditions. Our studies indicate a radial temperature gradient of 3.3 °C along with a transition period of 27.5 min when increasing the sample temperature from 37 to 45 °C for a standard 35 mm diameter Petri dish. We characterized the temperature gradient and transition period under various operational, geometric, and environmental conditions. Under stable conditions, reducing the diameter of the Petri dish and incorporating a heater underneath the Petri dish can effectively reduce the temperature gradient across the sample. In comparison, under transient conditions, reducing the diameter of the Petri dish, reducing sample volume, and using glass Petri dish chambers can reduce the transition period.
Comparative Study of Wind Turbine Placement Methods for Flat Wind Farm Layout Optimization with Irregular Boundary
Authors: Wang Longyan
Published: February 2019

For the exploitation of wind energy, planning/designing a wind farm plays a crucial role in the development of wind farm project, which must be implemented at an early stage, and has a vast influence on the stages of operation and control for wind farm development. As a step of the wind farm planning/designing, optimizing the wind turbine placements is an effective tool in increasing the power production of a wind farm leading to an increased financial return. In this paper, the optimization of an offshore wind farm with an irregular boundary is carried out to investigate the effectiveness of grid and coordinate wind farm design methods. In the study of the grid method, the effect of grid density on the layout optimization results is explored with 20 × 30 and 40 × 60 grid cells, and the means of coping with the irregular wind farm boundary using different wind farm design methods are developed in this paper. The results show that, depending on the number of installed wind turbines, a power output increase from 1% to 1.5% is achieved by increasing the grid density from 20 × 30 to 40 × 60. However, the computational time is more than doubled, rising from 23 h to 47 h with 40 wind turbines being optimized from the coarse grid cells to the densified grid cells. In comparison, the coordinate method is the best option for achieving the largest power increase of 1.5% to 2% (relative to the coarse 20 × 30 grid method), while the least computational time (21 h with 40 wind turbines optimized) is spent.
Soil-Gas Concentrations and Flux Monitoring at the Lacq-Rousse CO2-Geological Storage Pilot Site (French Pyrenean Foreland): From Pre-Injection to Post-Injection
Authors: Gal Frédérick , Pokryszka Zbigniew , Labat Nadège , Michel Karine , Lafortune Stéphane , Marblé André
Published: February 2019

Soil-gas concentrations and flux were measured during 20 separate measurement campaigns at the TOTAL Lacq-Rousse carbon capture and storage (CCS) pilot site, southern France, where 51,000 tons of CO2 were injected in a depleted natural gas field. Baseline data (September 2008 to December 2009) are compared to monitoring data from the injection (March 2010 to March 2013) and post-injection (February 2014 to December 2015) periods. CO2 soil-gas concentrations varied from atmospheric concentrations to more than 16% vol. with 1.4% as median value. Summer data showed high CO2 concentrations in the soil that remained quite high during winter. Median CO2 flux at the soil/atmosphere interface was close to 4.4 cm3·min−1·m−2. Carbon-isotope ratios measured on CO2 in soil gas had a mean value of −23.5 ± 3.1‰, some deviation being due to atmospheric CO2. Comparison between different gas species and the influence of temperature, pressure and soil-water content suggest that gases in near-surface environments are produced locally and naturally, and are unrelated to CO2 ascending from the storage reservoir. Monitoring of CO2 injection and the use of threshold levels is discussed as part of a practical approach considering specific regulations for the Lacq-Rousse CCS pilot experiment and constraints for the site operator.
A Feature Selection Method for Multi-Label Text Based on Feature Importance
Authors: Zhang Lu , Duan Qingling
Published: February 2019

Multi-label text classification refers to a text divided into multiple categories simultaneously, which corresponds to a text associated with multiple topics in the real world. The feature space generated by text data has the characteristics of high dimensionality and sparsity. Feature selection is an efficient technology that removes useless and redundant features, reduces the dimension of the feature space, and avoids dimension disaster. A feature selection method for multi-label text based on feature importance is proposed in this paper. Firstly, multi-label texts are transformed into single-label texts using the label assignment method. Secondly, the importance of each feature is calculated using the method based on Category Contribution (CC). Finally, features with higher importance are selected to construct the feature space. In the proposed method, the feature importance is calculated from the perspective of the category, which ensures the selected features have strong category discrimination ability. Specifically, the contributions of the features to each category from two aspects of inter-category and intra-category are calculated, then the importance of the features is obtained with the combination of them. The proposed method is tested on six public data sets and the experimental results are good, which demonstrates the effectiveness of the proposed method.
Cardiac Assist Devices: Early Concepts, Current Technologies, and Future Innovations
Authors: Han Jooli , Trumble Dennis R.
Published: February 2019

Congestive heart failure (CHF) is a debilitating condition that afflicts tens of millions of people worldwide and is responsible for more deaths each year than all cancers combined. Because donor hearts for transplantation are in short supply, a safe and durable means of mechanical circulatory support could extend the lives and reduce the suffering of millions. But while the profusion of blood pumps available to clinicians in 2019 tend to work extremely well in the short term (hours to weeks/months), every long-term cardiac assist device on the market today is limited by the same two problems: infections caused by percutaneous drivelines and thrombotic events associated with the use of blood-contacting surfaces. A fundamental change in device design is needed to address both these problems and ultimately make a device that can support the heart indefinitely. Toward that end, several groups are currently developing devices without blood-contacting surfaces and/or extracorporeal power sources with the aim of providing a safe, tether-free means to support the failing heart over extended periods of time.
PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer
Authors: Sau Samaresh , Petrovici Alex , Alsaab Hashem O. , Bhise Ketki , Iyer Arun K.
Published: February 2019

Targeting immune checkpoint molecules such as programmed death ligand-1 (PDL1) is an emerging strategy for anti-cancer therapy. However, transient expression of PDL1 and difficulty in tumor stroma penetration has limited the utility of anti-PDL1 therapy. To overcome these limitations, we report a new conjugate between the clinically approved PDL1 antibody (PDL1 AB) and drug Doxorubicin (Dox), named PDL1-Dox. We conjugated PDL1-Dox through a hydrazone linker containing a polyethylene glycol (PEG) spacer, which allows it to dissociate in a tumor environment and improves solubility. The purpose of using Dox is to disrupt the tumor extracellular environment so that PDL-1 antibody can penetrate the tumor core. PDL1-Dox demonstrates significant cell killing, disruption of tumor spheroid and induction of apoptosis in a breast cancer cell line. Significant release of IFN-γ suggests PDL1-Dox can upmodulate T cell activation. Optical imaging of dye conjugate supports the selective tumor targeting ability and core penetration of the construct.
Exploring lncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment: Advances and Challenges
Authors: Dong Peixin , Xiong Ying , Yue Junming , J. B. Hanley Sharon , Kobayashi Noriko , Todo Yukiharu , Watari Hidemichi
Published: February 2019

Recent studies have revealed both the promise and challenges of targeting long non-coding RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated or downregulated in ECs compared to normal tissues and their dysregulation has been linked to tumor grade, FIGO stage, the depth of myometrial invasion, lymph node metastasis and patient survival. Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-RoR) have been identified as upstream modulators or downstream effectors of major signaling pathways influencing EC metastasis, including the PTEN/PI3K/AKT/mTOR, RAS/RAF/MEK/ERK, WNT/β-catenin and p53 signaling pathways. TUG1 and TDRG1 stimulate the VEGF-A pathway. PCGEM1 is implicated in activating the JAK/STAT3 pathway. Here, we present an overview of the expression pattern, prognostic value, biological function of lncRNAs in EC cells and their roles within the tumor microenvironment, focusing on the influence of lncRNAs on established EC-relevant pathways. We also describe the emerging classification of EC subtypes based on their lncRNA signature and discuss the clinical implications of lncRNAs as valuable biomarkers for EC diagnosis and potential targets for EC treatment.
Antiglycative Activity and RAGE Expression in Rett Syndrome
Authors: Cordone Valeria , Pecorelli Alessandra , Benedusi Mascia , Santini Silvano , Falone Stefano , Hayek Joussef , Amicarelli Fernanda , Valacchi Giuseppe
Published: February 2019

Rett syndrome (RTT) is a human neurodevelopmental disorder, whose pathogenesis has been linked to both oxidative stress and subclinical inflammatory status (OxInflammation). Methylglyoxal (MG), a glycolytic by-product with cytotoxic and pro-oxidant power, is the major precursor in vivo of advanced glycation end products (AGEs), which are known to exert their detrimental effect via receptor- (e.g., RAGE) or non-receptor-mediated mechanisms in several neurological diseases. On this basis, we aimed to compare fibroblasts from healthy subjects (CTR) with fibroblasts from RTT patients (N = 6 per group), by evaluating gene/protein expression patterns, and enzymatic activities of glyoxalases (GLOs), along with the levels of MG-dependent damage in both basal and MG-challenged conditions. Our results revealed that RTT is linked to an alteration of the GLOs system (specifically, increased GLO2 activity), that ensures unchanged MG-dependent damage levels. However, RTT cells underwent more pronounced cell death upon exogenous MG-treatment, as compared to CTR, and displayed lower RAGE levels than CTR, with no alterations following MG-treatment, thus suggesting that an adaptive response to dicarbonyl stress may occur. In conclusion, besides OxInflammation, RTT is associated with reshaping of the major defense systems against dicarbonyl stress, along with an altered cellular stress response towards pro-glycating insults.
Quantitative Distribution of DNA, RNA, Histone and Proteins Other than Histone in Mammalian Cells, Nuclei and a Chromosome at High Resolution Observed by Scanning Transmission Soft X-Ray Microscopy (STXM)
Authors: Shinohara Kunio , Toné Shigenobu , Ejima Takeo , Ohigashi Takuji , Ito Atsushi
Published: February 2019

Soft X-ray microscopy was applied to study the quantitative distribution of DNA, RNA, histone, and proteins other than histone (represented by BSA) in mammalian cells, apoptotic nuclei, and a chromosome at spatial resolutions of 100 to 400 nm. The relative distribution of closely related molecules, such as DNA and RNA, was discriminated by the singular value decomposition (SVD) method using aXis2000 software. Quantities of nucleic acids and proteins were evaluated using characteristic absorption properties due to the 1s–π * transition of N=C in nucleic acids and amide in proteins, respectively, in the absorption spectra at the nitrogen K absorption edge. The results showed that DNA and histone were located in the nucleus. By contrast, RNA was clearly discriminated and found mainly in the cytoplasm. Interestingly, in a chromosome image, DNA and histone were found in the center, surrounded by RNA and proteins other than histone. The amount of DNA in the chromosome was estimated to be 0.73 pg, and the content of RNA, histone, and proteins other than histone, relative to DNA, was 0.48, 0.28, and 4.04, respectively. The method we present in this study could be a powerful approach for the quantitative molecular mapping of biological samples at high resolution.
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Authors: Jeusset Lucile M-P , McManus Kirk J
Published: February 2019

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers. Moreover, aberrant histone ubiquitination can drive oncogenesis by altering the expression of tumor suppressors and oncogenes, misregulating cellular differentiation and promoting cancer cell proliferation. Thus, targeting aberrant histone ubiquitination may be a viable strategy to reprogram transcription in cancer cells, in order to halt cellular proliferation and induce cell death, which is the basis for the ongoing development of therapies targeting histone ubiquitination. In this review, we present the normal functions of histone H2A and H2B ubiquitination and describe the role aberrant histone ubiquitination has in oncogenesis. We also describe the key benefits and challenges associated with current histone ubiquitination targeting strategies. As these strategies are predicted to have off-target effects, we discuss additional efforts aimed at developing synthetic lethal strategies and epigenome editing tools, which may prove pivotal in achieving effective and selective therapies targeting histone ubiquitination, and ultimately improving the lives and outcomes of those living with cancer.
Near-Zero Thermal Expansion in Freeze-Cast Composite Materials
Authors: Ellis Sarah N. , Romao Carl P. , White Mary Anne
Published: February 2019

Most materials expand when heated, which can lead to thermal stress and even failure. Whereas thermomiotic materials exhibit negative thermal expansion, the creation of materials with near-zero thermal expansion presents an ongoing challenge due to the need to optimize thermal and mechanical properties simultaneously. The present work describes the preparation and properties of polymer–ceramic composites with low thermal expansion. Ceramic scaffolds, prepared by freeze-casting of low-thermal-expansion Al2W3O12, were impregnated with poly(methylmethacrylate) (PMMA). The resulting composites can have a coefficient of thermal expansion as low as 2 × 10−6 K−1, and hardness values of 4.0 ± 0.3 HV/5 (39 ± 3 MPa) and 16 ± 3 HV/5 (160 ± 30 MPa) parallel and perpendicular to the ice growth, respectively. The higher hardness perpendicular to the ice growth direction indicates that the PMMA is acting to improve the mechanical properties of the composite.
Strategies for Coping with Time-Related and Productivity Challenges of Young People with Learning Disabilities and Attention-Deficit/Hyperactivity Disorder
Authors: Kreider Consuelo M. , Medina Sharon , Slamka Mackenzi R.
Published: February 2019

Learning disabilities (LD) and attention deficit hyperactivity disorder (ADHD) are characterized by neurological differences that result in difficulties meeting learning and productivity expectations. Young people with LD and ADHD experience difficulties in self-managing academic, social, daily living, and health/wellness demands. Students with LD/ADHD must work longer and harder than peers, which makes managing time and productivity a critical skill for school success. This study examined the strategies that college students with LD/ADHD used to overcome obstacles related to time and productivity within their everyday life contexts. A qualitative phenomenological design was used to examine the phenomenon of coping and productive-task performance through strategy use among 52 college students with LD/ADHD. Strategies classified as habit and routine use, reframing, and symptom-specific strategies were identified. Strategy use for addressing time-related and productivity challenges are multidimensional and entailed a mix of cognitive, behavioral, psychological, and socio-environmental strategies. Effective strategy use across life’s contexts was critical to self-managing as a young person with a chronic developmental condition within a college context. The findings provide a much-needed understanding of the multi-faceted challenges and solutions within young adult contexts that are important for guiding the development of interventions for young people with LD/ADHD.