bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and experimental assessment of a multi-annual energy monitoring tool to support energy intelligence and management in telecommunication industry
Authors: Sorrentino Marco , Franzese Nicola , Trifirò Alena
Published: July 2024

Carbon-footprint reduction of key industrial buildings is addressed, by proposing methodologies for continuously monitoring telecommunication (TLC) central offices (COs). Main aim is classifying sites according to their efficiency and reliability, via the diagnosis of anomalous electricity consumptions. Such a goal is achieved through the definition of new key performance indicators (KPIs) based on TLC and cooling energy demand, improving the outcomes of pre-existing methods. While the reliability index and index of cluster reliability are specifically proposed to evaluate and physically assess the impact of climate control (CLC, i.e., the parasitic quota) electricity consumption with respect to the TLC one, the here introduced coefficient of variation of telecommunication energy allows for a more solid evaluation of energy measurements reliability. Another target of this study is to extend the afore-mentioned KPIs-based analysis to multi-annual periods of monitoring, thus allowing successfully meeting the currently in-force ISO 50001 standard. Specific central offices were then selected and analyzed to verify the results physical meaning. The method was proven effective in classifying central offices belonging to climate-homogenous fleets, according to the reliability level estimated over a triannual timeframe. Positive impacts in terms of attainable energy saving through improved thermal management, as well as methodology extendibility to other industrial sectors are finally presented and discussed.
Asymptotic bounds on the numbers of certain bent functions
Authors: Potapov Vladimir N. , Özbudak Ferruh
Published: July 2024

Using recent results of Keevash et al. [10] and Eberhard et al. [8] together with further new detailed techniques in combinatorics, we present constructions of two concrete families of generalized Maiorana-McFarland bent functions. Our constructions improve the lower bounds on the number of bent functions in n variables over a finite field

$${\mathbb F}_p$$

F
p

if p is odd and n is odd in the limit as n tends to infinity. Moreover we obtain the asymptotically exact number of two dimensional vectorial Maiorana-McFarland bent functions in n variables over

$${\mathbb F}_2$$

F
2

as n tends to infinity.
Investigating the effect of Fusobacterium nucleatum on the aggressive behavior of cancer-associated fibroblasts in colorectal cancer
Authors: Eskandari-Malayeri Fatemeh , Rezeai Marzieh , Narimani Tahmineh , Esmaeil Nafiseh , Azizi Mahdieh
Published: July 2024

Fusobacterium nucleatum, (F. nucleatum) as a known factor in inducing oncogenic, invasive, and inflammatory responses, can lead to an increase in the incidence and progression of colorectal cancer (CRC). Cancer-associated fibroblasts (CAF) are also one of the key components of the tumor microenvironment (TME), which lead to resistance to treatment, metastasis, and disease recurrence with their markers, secretions, and functions. This study aimed to investigate the effect of F. nucleatum on the invasive phenotype and function of fibroblast cells isolated from normal and cancerous colorectal tissue. F. nucleatum bacteria were isolated from deep periodontal pockets and confirmed by various tests. CAF cells from tumor tissue and normal fibroblasts (NF) from a distance of 10 cm of tumor tissue were isolated from 5 patients by the explant method and were exposed to secretions and ghosts of F. nucleatum. The expression level of two markers, fibroblast activation protein (FAP), and α-smooth muscle actin (α-SMA), and the amount of production of two cytokines TGF-β and IL-6 from fibroblast cells were measured by flow cytometry and ELISA test, respectively before and after exposure to different bacterial components. The expression of the FAP marker was significantly higher in CAF cells compared to NF cells (P < 0.05). Also, the expression of IL-6 in CAF cells was higher than that of NF cells. In investigating the effect of bacterial components on the function of fibroblastic cells, after comparing the amount of IL-6 produced between the normal tissue of each patient and his tumoral tissue under 4 treated conditions, it was found that the amount of IL-6 production from the CAF cells of patients in the control group, treated with heat-killed ghosts and treated with paraformaldehyde-fixed ghosts had a significant increase compared to NF cells (P < 0.05). Due to the significant increase in FAP marker expression in fibroblast cells of tumor tissue compared to normal tissue, it seems that FAP can be used as a very good therapeutic marker, especially in patients with high levels of CAF cells. Various components of F. nucleatum could affect fibroblast cells differentially and at least part of the effect of this bacterium in the TME is mediated by CAF cells.
Daptomycin eosinophilic pneumonia, a systematic review of the literature and case series
Authors: Gidari Anna , Pallotto Carlo , Francisci Daniela
Published: July 2024

Purpose

Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare yet severe adverse event that requires rapid recognition and management. Diagnosing a definite case is challenging and involves meeting the American Thoracic Society (ATS) criteria, although alternative criteria have been suggested. This study aims to conduct a systematic review of literature and includes a case series.

Methods

Six cases of DIEP identified at Perugia Hospital, Perugia, Italy have been described. A systematic review was carried out adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines.

Results

a total of 74 cases of DIEP were analysed. Using ATS clinical criteria, 15 were classified as definite (20.3%), 54 as probable (73.0%), and 5 as possible (6.8%). Phillips criteria and the Lyon Algorithm identified 43/74 (58.2%) and 64/67 (95.5%) cases as definite, respectively. Bronchoalveolar lavage (BAL) was performed in 43 cases, revealing an average eosinophil count of 28.6% (SD 24.4). Radiological findings highlighted recurring features like bilateral opacities (68.1%), ground-glass opacities (41.7%), patchy infiltrates (30.6%), and peripheral predominance (19.4%). Upon suspicion, daptomycin was discontinued; 20 cases required no additional treatment, 38 received corticosteroids, and 12 received both corticosteroids and antibiotics. Recovery rates were high across all treatment types (≥ 73.7%). Most reports described rapid improvement post-withdrawal (within 96 h).

Conclusions

DIEP is a rare, fast-progressing condition where early diagnosis and prompt treatment are vital. Diagnosis relies on clinical, laboratory, and radiological evaluations. Stopping daptomycin is essential, with corticosteroids often necessary. Further research is needed to enhance diagnostic accuracy for this disease.
Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice
Authors: Yan Ding , Wu XinTian , Chen Xi , Wang Jiangtuan , Ge Feifei , Wu Meixuan , Wu Jiawen , Zhang Na , Xiao Min , Wu Xueheng , Xue Qian , Li Xiaofen , Chen Jinghong , Wang Ping , Tang Daolin , Wang Xin , Chen Xin , Liu Jinbao
Published: July 2024

Hyperbilirubinaemia is a prevalent condition during the neonatal period, and if not promptly and effectively managed, it can lead to severe bilirubin-induced neurotoxicity. Sunflower seeds are a nutrient-rich food source, particularly abundant in linoleic acid. Here, we provide compelling evidence that lactating maternal mice fed a sunflower seed diet experience enhanced neurological outcomes and increased survival rates in hyperbilirubinemic offspring. We assessed histomorphological indices, including cerebellar Nissl staining, and Calbindin staining, and hippocampal hematoxylin and eosin staining. Furthermore, we observed the transmission of linoleic acid, enriched in sunflower seeds, to offspring through lactation. The oral administration of linoleic acid-rich sunflower seed oil by lactating mothers significantly prolonged the survival time of hyperbilirubinemic offspring mice. Mechanistically, linoleic acid counteracts the bilirubin-induced accumulation of ubiquitinated proteins and neuronal cell death by activating autophagy. Collectively, these findings elucidate the novel role of a maternal linoleic acid-supplemented diet in promoting child health.
Integrated image-based deep learning and language models for primary diabetes care
Authors: Li Jiajia , Guan Zhouyu , Wang Jing , Cheung Carol Y. , Zheng Yingfeng , Lim Lee-Ling , Lim Cynthia Ciwei , Ruamviboonsuk Paisan , Raman Rajiv , Corsino Leonor , Echouffo-Tcheugui Justin B. , Luk Andrea O. Y. , Chen Li Jia , Sun Xiaodong , Hamzah Haslina , Wu Qiang , Wang Xiangning , Liu Ruhan , Wang Ya Xing , Chen Tingli , Zhang Xiao , Yang Xiaolong , Yin Jun , Wan Jing , Du Wei , Quek Ten Cheer , Goh Jocelyn Hui Lin , Yang Dawei , Hu Xiaoyan , Nguyen Truong X. , Szeto Simon K. H. , Chotcomwongse Peranut , Malek Rachid , Normatova Nargiza , Ibragimova Nilufar , Srinivasan Ramyaa , Zhong Pingting , Huang Wenyong , Deng Chenxin , Ruan Lei , Zhang Cuntai , Zhang Chenxi , Zhou Yan , Wu Chan , Dai Rongping , Koh Sky Wei Chee , Abdullah Adina , Hee Nicholas Ken Yoong , Tan Hong Chang , Liew Zhong Hong , Tien Carolyn Shan-Yeu , Kao Shih Ling , Lim Amanda Yuan Ling , Mok Shao Feng , Sun Lina , Gu Jing , Wu Liang , Li Tingyao , Cheng Di , Wang Zheyuan , Qin Yiming , Dai Ling , Meng Ziyao , Shu Jia , Lu Yuwei , Jiang Nan , Hu Tingting , Huang Shan , Huang Gengyou , Yu Shujie , Liu Dan , Ma Weizhi , Guo Minyi , Guan Xinping , Yang Xiaokang , Bascaran Covadonga , Cleland Charles R. , Bao Yuqian , Ekinci Elif I. , Jenkins Alicia , Chan Juliana C. N. , Bee Yong Mong , Sivaprasad Sobha , Shaw Jonathan E. , Simó Rafael , Keane Pearse A. , Cheng Ching-Yu , Tan Gavin Siew Wei , Jia Weiping , Tham Yih-Chung , Li Huating , Sheng Bin , Wong Tien Yin
Published: July 2024

Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary care physicians (PCPs), particularly in low-resource settings. Here, to bridge the gaps, we developed an integrated image–language system (DeepDR-LLM), combining a large language model (LLM module) and image-based deep learning (DeepDR-Transformer), to provide individualized diabetes management recommendations to PCPs. In a retrospective evaluation, the LLM module demonstrated comparable performance to PCPs and endocrinology residents when tested in English and outperformed PCPs and had comparable performance to endocrinology residents in Chinese. For identifying referable DR, the average PCP’s accuracy was 81.0% unassisted and 92.3% assisted by DeepDR-Transformer. Furthermore, we performed a single-center real-world prospective study, deploying DeepDR-LLM. We compared diabetes management adherence of patients under the unassisted PCP arm (n = 397) with those under the PCP+DeepDR-LLM arm (n = 372). Patients with newly diagnosed diabetes in the PCP+DeepDR-LLM arm showed better self-management behaviors throughout follow-up (P < 0.05). For patients with referral DR, those in the PCP+DeepDR-LLM arm were more likely to adhere to DR referrals (P < 0.01). Additionally, DeepDR-LLM deployment improved the quality and empathy level of management recommendations. Given its multifaceted performance, DeepDR-LLM holds promise as a digital solution for enhancing primary diabetes care and DR screening.
Multi objective optimization and evaluation approach of prefabricated component combination solutions using NSGA-II and simulated annealing optimized projection pursuit method
Authors: Wang Qun , Xu Xizhen , Ding Xiaoxin , Chen Tiebing , Deng Ronghui , Li Jinglei , Jiang Jiawei
Published: July 2024

As a main carrier mode for the sustainable development of the construction industry in China, prefabricated building may lead to problems such as cost overruns, project delays, and waste of resources due to unreasonable selection of prefabricated components. Therefore, we quantitatively analyze the contribution rate of quality optimization of prefabricated components using QFD-SEM. Under the constraints of prefabrication rate, quality optimization contribution rate, and expected values of various sub-goals, we propose a multi-objective optimization method for prefabricated component combinations based on cost, duration, and carbon emissions. By using NSGA-II to solve the model, we can obtain a set of optimal Pareto solutions for prefabricated component combinations. Based on the optimal Pareto solution set, we establish a multi-objective evaluation model using simulated annealing optimization projection tracing method, and select the optimal prefabricated component combination solution according to the projected eigenvalues of the solutions. An empirical study is conducted using an eleven-story framed building in Shenzhen, Guangdong Province, China as a case study. The results show that: (1) Using this method, optimal solutions can be obtained in an unbounded solution space, with the optimal solution having advantages over both fully cast-in-place and fully prefabricated solutions. Compared to the fully cast-in-place solution, the duration and carbon emissions are reduced by 36.62% and 12.74% respectively, while compared to the fully prefabricated solution, costs are reduced by 4.15%. (2) There is a certain negative correlation between the cost of prefabricated component combinations and duration, carbon emissions, and quality optimization, while there is a certain positive correlation with the prefabrication rate. (3) The size of the optimal projection direction vector based on the optimization objectives indicates that carbon emissions have the greatest impact on the evaluation results of the solutions.
Inflammatory bowel disease and risk for hemorrhoids: a Mendelian randomization analysis
Authors: Wang HanYu , Wang Lu , Zeng XiaoYu , Zhang ShiPeng , Huang Yong , Zhang QinXiu
Published: July 2024

Observational studies have reported an association between inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), and hemorrhoids (HEM). However, the presence of a causal relationship within this observed association remains to be confirmed. Consequently, we utilized the Mendelian randomization (MR) method to assess the causal effects of IBD on hemorrhoids. We validated the association between IBD and hemorrhoids in humans based on genome-wide association studies (GWAS) data. To investigate the causal relationship between IBD and hemorrhoids, we performed a two-sample Mendelian randomization study using training and validation sets. The genetic variation data for IBD, CD, UC, and hemorrhoids were derived from published genome-wide association studies (GWAS) of individuals of European. Two-sample Mendelian randomization and Multivariable Mendelian randomization (MVMR) were employed to determine the causal relationship between IBD (CD or UC) and hemorrhoids. Genetically predicted overall IBD was positively associated with hemorrhoids risk, with ORs of 1.02 (95% CIs 1.01–1.03, P = 4.39 × 10−4) and 1.02 (95% CIs 1.01–1.03, P = 4.99 × 10−5) in the training and validation sets, respectively. Furthermore, we found that CD was positively associated with hemorrhoids risk, with ORs of 1.02 (95% CIs 1.01–1.03, P = 4.12 × 10−6) and 1.02 (95% CIs 1.01–1.02, P = 3.78 × 10−5) for CD in the training and validation sets, respectively. In addition, we found that UC in the training set was positively associated with hemorrhoids risk (ORs 1.02, 95% CIs 1.01–1.03, P = 4.65 × 10−3), while no significant causal relationship between UC and hemorrhoids was shown in the validation set (P > 0.05). However, after MVMR adjustment, UC in the training set was not associated with an increased risk of hemorrhoids. Our study showed that there is a causal relationship between CD and hemorrhoids, which may suggest that clinicians need to prevent the occurrence of hemorrhoids in CD patients.
Do body colour and sociability impact scototaxis response of fish?
Authors: Pecunioso Alessandra , Aleotti Elena , Agrillo Christian
Published: July 2024

Scototaxis test is an anxiety-like test used by behavioural neuroscientists consisting in the assessment of dark/light preference of laboratory animals. This test has been widely used in fish. Most of the species have been shown to express a preference for the dark environment. However, the majority of the investigated species has a dark body colour, thus making a clear contrast with a white/bright background. Also, while in nature fish tend to be highly social, studies in the scototaxis literature tested single fish. Yet, individual vs. group behaviour might interact with scototaxis response. In experiment 1, we assessed the individual response to test the hypothesis that the different colours of the body might modulate the dark/light preference. We found that species with a dark body colour (Hyphessobrycon megalopterus) and a largely transparent body colour (Kryptopterus bicirrhis) strongly preferred the darker environment. Instead, the preference for darkness of a species with a luminescent part of the body (Paracheirodon axelrodi) was less pronounced. Lastly, a species with a white body colour (Corydoras albini) did not prefer either a bright or a dark sector. In experiment 2, we explored the behaviour of these species when inserted in shoals of 20 individuals in the experimental apparatus. While H. megalopterus and K. bichirrhis confirmed their robust preference for darker environments, the other two species changed their preference. Taken together, these results suggest that scototaxis response is context-dependent, as it appears to be modulated by the body colour and the presence/absence of other conspecifics in the surrounding.
Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells
Authors: Deng Bo , Xian Ruyu , Shu Yuan , Xia Haohan , Feng Chengcheng
Published: July 2024

To investigate the role of miR-223-3p in the modulatory effect of paeonol (Pae) on high glucose (HG)-induced endothelial cell apoptosis. HG (25 mmol/L) was used to induce cellular damage and apoptosis in the mouse cardiac microvascular endothelial cells (MCMECs). Various concentration of Pae was tested and 60 μmol/L Pae was selected for the subsequent studies. MCMECs were transfected with exogenous miR-223-3p mimics or anti-miR-223-3p inhibitors. Cell viability was assessed by MTT assay and apoptosis was quantified by flow cytometry. The expression of miR-223-3p and NLRP3 mRNA was measured using real-time quantitative RT-PCR, and protein level of NLRP3 and apoptosis-related proteins was detected by immunoblotting. Pae significantly attenuated HG-induced apoptosis of MCMECs in a concentration-dependent manner. In addition, Pae (60 µmol/L) significantly reversed HG-induced down-regulation of miR-223-3p and up-regulation of NLRP3. Pae (60 µmol/L) also significantly blocked HG-induced up-regulation of Bax and Caspase-3 as well as down-regulation of Bcl-2. Moreover, exogenous miR-223-3p mimics not only significantly attenuated HG-induced apoptosis, but also significantly suppressed NRLP-3 and pro-apoptotic proteins in the MCMECs. In contrast, transfection of exogenous miR-223-3p inhibitors into the MCMECs resulted in not only significantly increased apoptosis of the cells, but also significant suppression of NLRP3 and pro-apoptotic proteins in the cells. Pae attenuated HG-induced apoptosis of MCMECs in a concentration-dependent manner. MiR-223-3p may mediate the modulatory effects of Pae on MCMEC survival or apoptosis through targeting NLRP3 and regulating apoptosis-associated proteins.
Injectable Smart Hydrogels: Introduction, Preparation, and Applications
Authors: Dodda Jagan Mohan , Tsai Shiao-Wen , Ashammakhi Nureddin
Published: July 2024

This chapter primarily provides a succinct introduction to the key developments in smart injectable hydrogels. The focal points include their diverse categories, inherent advantages and distinguishing features. The chapter further elucidates the properties of smart hydrogels and discusses the mechanisms employed for the formation of these hydrogels through crosslinking methods. The latter part of this chapter highlights the applications of smart hydrogels in the medical field. This chapter can serve as an essential resource for those seeking to understand the fundamental features and multifaceted potential of injectable smart hydrogel materials. It ensures that readers will gain a thorough understanding of this versatile field.
Click Chemistry-based Injectable Smart Hydrogels
Authors: Ueda Natsumi , Nagahama Koji
Published: July 2024

Injectable hydrogels generated by click chemistry-based covalent bonding have been investigated as potential smart biomaterials for application in medical devices, drug delivery systems (DDS), regenerative medicine, and tissue engineering. In this chapter, we introduce traditional click chemistry-based injectable smart hydrogels prepared with chemical cross-linking of biocompatible polymers. Additionally, we show our cell cross-linked hydrogels in which living cells are covalently cross-linked with polymer gel networks as new generation click chemistry-based injectable gels.
Advances in anode current collectors with a lithiophilic gradient for lithium metal batteries
Authors: Gao Chenglin , Kang Jianli , Zhang Yimin , He Chunnian , Shi Chunsheng , Chen Biao , Ma Liying , Liu Enzuo , Sha Junwei , Zhou Fengxin , Zhao Naiqin
Published: July 2024

Summary of Li–metal anode current collectors with different lithiophilic gradient designs.
Modular polyketide synthase ketosynthases collaborate with upstream dehydratases to install double bonds
Authors: Ray Katherine A. , Saif Nisha , Keatinge-Clay Adrian T.
Published: July 2024

A VMYH motif was determined to help ketosynthases in polyketide assembly lines select α,β-unsaturated intermediates from an equilibrium mediated by an upstream dehydratase.
Seeded-growth synthesis of dispersed Co9S8 nanoparticles loaded in carbon aerogel as efficient bi-catalysts towards the ORR and HER
Authors: Fang Hetong , Lv Hang , Liu Xuehui , Li Shengnan , Xia Haibing
Published: July 2024

A high density of dispersed Co9S8 nanoparticles loaded in carbon aerogels were successfully prepared by the mimetic seeded-growth method.
Organic ammonium salt assisted crystallization and defect passivation of a quasi-two-dimensional pure blue perovskite at the buried interface
Authors: Zhu Mingyi , Dong Jie , Du Kang , Li Huitian , Jiang Na , Xu Zheng , Zhao Suling , Liang Zhiqin , Song Dandan , Qiao Bo
Published: July 2024

Quasi-two-dimensional (quasi-2D) perovskites exhibit excellent performance in light-emitting diodes (LEDs).
Digital nets conformational sampling (DNCS) – an enhanced sampling technique to explore the conformational space of intrinsically disordered peptides
Authors: J. Abraham Rebairo , D. Sam Paul , Arumainathan Stephen
Published: July 2024

We propose digital nets conformational sampling (DNCS) – an enhanced sampling technique to explore the conformational ensembles of peptides, especially intrinsically disordered peptides (IDPs).
Enhancing simulation feasibility for multi-layer 2D MoS2 RRAM devices: reliability performance learnings from a passive network model
Authors: Lee Seonjeong , Huang Yifu , Chang Yao-Feng , Baik Seungjae , Lee Jack C. , Koo Minsuk
Published: July 2024

This paper presents a novel simulator aimed at providing an intuitive, visual representation of the stochastic behaviors involved in the RS process of multi-layer 2D MoS2 RRAM devices.
Metal-free decarboxylative C(sp3)–C(sp3) bond formation for the synthesis of unnatural amino acids and peptides via convergent paired electrolysis enabled radical–radical cross-coupling
Authors: Ye Zenghui , Chen Na , Zhang Hong , Wu Yanqi , Zhang Fengzhi
Published: July 2024

Herein, we present the first metal-free decarboxylative C(sp3)–C(sp3) cross-coupling of glycine derivatives with redox-active esters through highly atom and energy economical convergent paired electrolysis enabled radical–radical cross-coupling.
Multifunctionalized zirconium-based MOF as a novel support for dispersed copper: application in CO2 adsorption and catalytic conversion
Authors: Rosado Albert , Popa Ioana-Maria , Markeb Ahmad Abo , Moral-Vico Javier , Naughton Eva Maria , Eckhardt Hans-Georg , Ayllón José A. , López-Periago Ana M. , Domingo Concepción , Negahdar Leila
Published: July 2024

A novel multifunctionalized NU-1000 MOF-Cu material is designed for CO2 adsorption and catalytic conversion. This Cu-based catalyst is active in electrocatalysis and has excellent selectivity to methanol formation in thermocatalytic hydrogenation.
Mode d'action de la desloréline et ses conséquences
Authors: de Meyrignac Éléonore
Published: July 2024

La desloréline a une structure chimique très proche de la GnRH endogène. Cependant, des modifications dans la séquence d’acides aminés ont été apportées, lui conférant une affinité de liaison pour les récepteurs à la GnRH 7 fois supérieure à celle de la GnRH endogène. Il s’agit donc d’un agoniste de la GnRH.

Le mécanisme d'action se fait en deux temps lorsque celle-ci est administrée sous forme d'implant. Dans un premier temps, la desloréline se fixe sur les récepteurs hypophysaires de la GnRH, mimant ainsi ses effets. La sécrétion de LH et FSH résultant de cette stimulation des récepteurs entraîne une production d'hormones sexuelles (effet flare-up).

Dans un second temps, la libération prolongée de la molécule aboutit à la désensibilisation de ces récepteurs, ce qui entraîne une chute de LH et FSH et un effondrement des hormones sexuelles. L’animal est alors stérile et les comportements liés aux hormones sexuelles sont diminués ou absents.

Lorsque la desloréline est utilisée sous forme injectable, la durée d’action est courte, et seule la phase de stimulation de la sécrétion de FSH et LH est présente. On observe alors un déclenchement des chaleurs chez les femelles, et une possible exacerbation des comportements sexuels chez les mâles.

La compréhension du mode d’action de cette molécule permet d’appréhender et d’expliquer aux propriétaires les effets des implants de desloréline sur la fertilité et le comportement sexuel de l’animal.
Castration réversible du chien mâle : quelles méthodes utiliser ?
Authors: Topie Emmanuel
Published: July 2024

La desloréline dispose d'une AMM en Europe chez le chien mâle sous forme d’implant à libération prolongée de 4,7 mg et 9,4 mg (Suprelorin®) pour l’induction d’une infertilité temporaire chez les chiens mâles arrivés à maturité sexuelle, non castrés et en bonne santé. Après une stimulation initiale, l'implant induit une diminution de la sécrétion de gonadotropines et de testostérone.

Ses indications sont le contrôle de la reproduction en présence de femelles, le contrôle des agressions en présence d’autres mâles, de tester de manière réversible l’intérêt de la castration sur des comportements indésirables, de remplacer la castration chirurgicale lorsque celle-ci n’est pas envisageable (choix du propriétaire, risque anesthésique), et le traitement ou la prévention de l’hyperplasie bénigne de la prostate asymptomatique.

Le délai d’action est de 6 semaines pour le Suprelorin® dosé à 4,7 mg et de 8 à 12 semaines pour le Suprelorin® dosé à 9,4 mg. Les durées d’action des deux dosages sont de respectivement 6 à 12 mois et d’au moins 12 mois.

Une diminution du volume prostatique et testiculaire (> 50%) et une régression des comportements liés à l’activité sexuelle (hypersexualité, agressions intra-spécifiques, marquage urinaire) sont observées.

Historiquement, les progestatifs ont été utilisés dans l'indication de la castration chimique réversible. Ils sont de moins en moins employés en raison d’une balance bénéfices-risques moins favorable.
La contraception des petits mammifères et autres NAC :
quelle utilisation des implants ?
Authors: Claude William , Pignon Charly
Published: July 2024

La desloréline est un analogue synthétique compétitif de l’hormone GnRH agissant sur l’axe hypothalamo-hypophysaire et provoquant dans le temps une forte diminution du relargage des hormones gonadotropes, stimulantes des follicules (FSH) et lutéinisantes (LH). L’effet final est une stérilisation chimique par arrêt de production des spermatozoïdes, arrêt des cycles ovariens et diminution des comportements sexuels.

Ses effets et son efficacité sont très bien connus chez le chien et le chat mais nécessitent encore beaucoup d’études chez les NAC. Plusieurs publications démontrent que l’on peut l’utiliser comme méthode de stérilisation chimique chez des espèces comme le furet en particulier et le rat, bien qu’il nous manque à ce jour quelques données sur les durées exact d’efficacité.

L’implant de desloréline semble également fonctionner chez la lapine (alors qu’il est inefficace chez le mâle).

Son intérêt est cependant limité car il ne prévient pas du développement des affections de l’utérus.
Writing to evaluate
Authors: Xuan Winfred Wenhui , Chen Shukun
Published: July 2024

Evaluative language is crucial in English for Academic Purposes (EAP) writing, particularly in expressing
authorial stance and supporting arguments. Among various linguistic frameworks, appraisal in Systemic Functional Linguistics (SFL)
has been extensively used to map and assess evaluative linguistic features. Since its inception in the early 1990s, appraisal has
been widely applied to EAP writing studies. This synthesis reviews EAP writing studies using the appraisal framework published
over the past decades, synthesizing 69 publications. We developed coding schemes based on research questions, focusing on learner
levels, subjects studied, text type, and generated findings. Our findings indicate that appraisal has been applied by EAP writers
at different levels to perform a range of functions in their writing. However, previous studies show that there is a lack of
longitudinal study of appraisal resources used by EAP writers at different levels. We recommend systematic and explicit
instruction in the use of appraisal resources in EAP writing. Based on our findings, we offer pedagogical
suggestions for EAP writing and teaching, aiming to enhance the effectiveness of EAP instruction and the quality of student
writing.
Transformative Reading
Authors: Fialho Olivia
Published: July 2024

Transformative Reading belongs to a growing tradition of studies investigating the functions of aesthetic experiences in our lives. Philosophers, literary theorists, and psychologists have suggested that aesthetic experiences implicate and develop our sense of ourselves. Literary texts, as one such experience, challenge readers and extend their imagination by means of complex or deviating plots. Reading literary narrative fiction helps readers develop imaginary selves in a safe way, enhancing their theory of mind. It might also contribute to the development of readers’ interpersonal competencies and foster pro-sociality, altruistic behaviour, and empathy. This book uses empirical research methods to focus on the processes of literary reading, revealing two pathways for the transformative powers of literature. It also reveals how an understanding of these pathways might be beneficial in educational settings – in schools, in the workplace, and in medical contexts.
Structures in discourse
Authors: Wårvik Brita
Published: July 2024

Texts are expected to have structure and the study of
that structure is a central concern in text and discourse linguistics. Texts
are semantic units and their structure is therefore a matter of organization
of the content material included in them. At the same time, text structure
is also a matter of form, since texts manifest linguistic signals of various
kinds whose purpose is to facilitate the text receiver’s task of
interpretation, i.e. the task of building a text world around a given text.
And even shape can be used to disclose the structure of a given text. (Virtanen 1997a)
WITHDRAWN: Photonics of Two-Dimensional Structures Formed by Cholesteric Liquid Crystals
Authors: Dolganov P. V. , Baklanova K. D. , Dolganov V. K.
Published: July 2024

Notice of Withdrawal

This paper was withdrawn by IOP Publishing on 30/08/2024. This paper was published due to an error. The authors are free to publish this work elsewhere. IOP Publishing apologise for this error.
Digital pedagogy: experiential learning theory improves mathematics learners’ engagement and learning outcomes in optical physics course
Authors: Lima Amanda de Barros , Sorroche Julia , Tagiku Armando Massao , Neto Jose Dutra de Oliveira
Published: July 2024

In response to the evolving educational landscape during the COVID-19 pandemic, this study explores the application of experiential learning theory (ELT) in an Optical Physics course for mathematics undergraduates. With a focus on improving engagement and academic performance, we address the critical need for effective pedagogical approaches in a virtual environment. The study involves 176 students, encompassing a wide demographic spectrum, during 2021, and utilises an extensive theoretical framework to support the ELT approach. The core of the study is an innovative learning model based on hands-on experiments, designed to enhance engagement, deepen understanding, and promote active learning. Students perform a series of experiments, reflect on their observations, connect theory to practice, and answer challenging questions that link theoretical concepts with real-world applications. Our results reveal a significant improvement in students’ academic outcomes, with higher average grades and reduced course abandonment compared to the previous year. The study also explores students’ perceptions, revealing their appreciation for this active learning approach, as it enhances motivation, concentration, enjoyment, and perceived learning. Collecting data through questionnaires, in-class feedback, andpost-class email reflections further validates the effectiveness of the Kolb-based ELT approach. In conclusion, our study demonstrates the power of implementing hands-on experiential learning in virtual education settings, fostering deeper engagement and improved academic outcomes, especially in a post-pandemic world where such pedagogical innovation is vital.
SiPM and readout electronics for the JUNO-TAO Central Detector
Authors: Venettacci C. ,   the JUNO collaboration
Published: July 2024

The Taishan Antineutrino Observatory (TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). TAO consists of a spherical ton-level Gadolinium-doped Liquid Scintillator detector and its main purpose is the precise measurement of the reactor antineutrino spectrum by detection of light produced in v̅e
+ p⟶ e
+ + n reaction, as a reference for JUNO. About 4,500 photoelectrons per MeV could be detected by instrumenting the sphere surface (∼10 m2) with state-of-the-art Silicon PhotoMultipliers (SiPMs), resulting in a sub-percent energy resolution. In this work we present the implemented architecture of the readout electronics based on low-noise, high-speed Front-End Boards (FEBs) connected to a 50×50 mm2 SiPM Hamamatsu tile, composed by 32 SiPM elements of 12×6 mm2 each, divided into two independent output channels. The overall 4,024 FEBs will be supplied through eight custom flanges that have to bring in about 1.5 kW. On the same flanges the 8,048 output signal cables are distributed and routed to the Front-End Controllers (FECs), based on Virtex Ultrascale FPGAs, able to manage up to eight 16-channel ADCs, for a total of 128 channels on a single FEC, with a maximum sampling rate of 250 MHz with 12-bit resolution. A dedicated trigger and data-acquisition system will filter and record occurring events, rejecting dark count events. We report the results of the characterization for the pre-production FEBs batch, following the main figures of merit defined for the experiment, showing single photoelectron resolution better than 13% and dynamic range up to 250 photoelectrons.
A novel method to simulate radon exhalation rate with a solid Rn-222 source
Authors: Li Huiying , Fan Zhongkai , Liu Shuaibin , Lin Fen , Hu Tao , Mo Yixiang , Yuan Shuai , Xie Ruomei , Sun Jiale , Yi Haibo , Liu Zhipeng , Wu Jiulin , Yuan Hongzhi , Tan Yanliang
Published: July 2024

Radon exhaled from rocks, building materials, and soil can
be harmful to human health, so it is necessary to measure radon and
its exhalation rate. In this paper, a novel method is proposed to
simulate radon exhalation from different medium surface by using a
solid Rn-222 source, and the radon exhalation rate can be adjusted
by replacing radon accumulation chambers with different bottom
areas. Firstly, an experiment was done to determine the activity of
the Rn-222 source, and then the theoretical radon exhalation rate
can be quickly calculated from the relationship between the radon
source activity and the bottom area of the radon accumulation
chamber. Three sets of comparative experiments were conducted using
two radon accumulation chambers with different volumes,
respectively. Comparing the average values obtained from the
experiments with the calculated theoretical values, it can be
obtained that the differences corresponding to the two radon
accumulation chambers between the theoretical radon exhalation rates
and the experimentally average values are all within 6%. Without
replacing the radon source, the radon exhalation rate is inversely
varies with the bottom area of the chamber. Therefore, the
correctness of adjusting the radon exhalation rate by replacing
radon accumulation chambers with different bottom areas to simulate
radon exhalation from different media surfaces is verified. This
method can be used to calibrate the radon exhalation measuring
instruments.
Image reconstruction from speckle patterns on double diffusers condition by deep learning
Authors: Chai Shouyu , Wang Jialong , Lu Mengyang , Gu Wenting , Li Boyi , Liu Xin
Published: July 2024

Reconstructing images from speckle patterns using deep learning methods is emerging as an effective alternative to traditional approaches. To overcome the potential multiple diffuser distortions occurring between the emission and the detection of the optical path, we establish a 4-f imaging system incorporating dual diffusers, one positioned in front of the image plane and the other after the object plane, to capture plenty of scattered object images. To effectively reconstruct from the experimentally acquired speckle patterns, we add the Triple Attention Module into the UNeXt convolutional network (TAM-UNeXt) and concurrently preprocess the autocorrelation spectrum of the patterns inspired by the angular memory effect theory. We compare the recovery results of the TAM-UNeXt under various conditions, including different grit sizes, numbers, and positions of the diffusers, as well as several optical lens setups, to verify its adaptability under diverse double diffuser conditions.
A reciprocity relation for the twisted second moment of the Riemann Zeta function
Authors: Khan Rizwanur
Published: July 2024

We prove a reciprocity relation for the twisted second moment of the Riemann Zeta function. This provides an analogue to a formula of Conrey for Dirichlet

L
L

-functions.
Compact sheaves on a locally compact space
Authors: Harr Oscar
Published: July 2024

Let

X
X

be a hypercomplete locally compact Hausdorff space and let

C

\mathcal C

be a compactly generated stable

∞
\infty

-category. We describe the compact objects in the

∞
\infty

-category of

C

\mathcal C

-valued sheaves

S
h
v
(
X
,

C

)

Shv(X,\mathcal C)

. When

X
X

is a non-compact connected manifold and

C

\mathcal C

is the unbounded derived

∞
\infty

-category of a ring, our result recovers a result of Neeman. Furthermore, if

C

\mathcal C

is a nontrivial compactly generated stable

∞
\infty

-category, we show that

S
h
v
(
X
,

C

)

Shv(X,\mathcal C)

is compactly generated if and only if

X
X

is totally disconnected.
Essays on Perceptual Experience
Authors: Snowdon Paul F
Published: July 2024

A central figure in Anglo-American philosophy for over four decades, Paul Snowdon made seminal contributions to the fields of metaphysics, philosophy of mind, and the history of twentieth-century philosophy. Snowdon’s work on perception and perceptual experience—much of which is collected in this volume for the first time—was particularly impactful and firmly established “disjunctivism” as a view with which any theorist working in the field must reckon. In Part 1 (“Issues”), Snowdon traces the contours of the concept of perception, refining his formulation of the disjunctivist position, determining the degree of involvement of the concept of causation, and engaging critically with arguments which aim to support sense-data theories. In its critical examination of the views propounded by a number of influential philosophers, Part 2 (“Philosophers”) amounts to a partial sketch of the history of twentieth-century philosophy of perception. Among the figures whose work Snowdon engages are J. L. Austin, A. J. Ayer, Michael Ayers, Michael Hinton, John McDowell, G. E. Moore, H. H. Price, Wilfrid Sellars, P. F. Strawson, and Ludwig Wittgenstein. The volume opens with a robust and generous introduction in which Snowdon describes the theoretical challenges, approaches, and themes that animate the set of interrelated problems addressed across all sixteen chapters. Sprinkled throughout are an array of candid reflections that serve both to illuminate substantive connections between the chapters as well as the historical and circumstantial contexts that occasioned their writing.
Some Reflections on an Argument from Hallucination
Authors: Snowdon Paul F
Published: July 2024

The aim of the present chapter is to evaluate the strongest possible formulation of the argument from hallucination. To this end, the traditional argument is presented, refined, and strengthened, culminating in a formulation of the argument recently advanced by Howard Robinson. Following additional refinements and bolstering, various attempts to block Robinson’s argument are found either to be unsuccessful (in the case of Matthew Soteriou’s response) or ill-advised (in the case of resistance flowing from a commitment to dualism). In the final two sections, a new response is explored which begins by revealing the argument’s commitment to a conception of perceptual experience as the immediate effect of an inner neural cause. It is then demonstrated how the argument can be neutralized by understanding perceptual experience as consisting of a temporally extended physical process back to, and so including, the external object.
On the What-It-Is-Like-ness of Experience
Authors: Snowdon Paul F
Published: July 2024

It is common for philosophers to hold that experiences can be characterized in terms of their possessing something best capturable in such words as ‘being like something to undergo’. It is argued here that when this slogan is examined it is in some respects trivial (because experiences must be some way, and being events must be some way for the subject of them) and in others mistaken (because there can be non-experiences which can be like something for a thing to undergo). Thus, it is recommended that philosophers stop repeating the slogan.
G. E. Moore on Sense-Data and Perception
Authors: Snowdon Paul F
Published: July 2024

In his acute study of G. E. Moore, G. E. Moore: A Critical Exposition, A. R. White writes: “There are three main topics dealt with in Moore’s writings, namely, philosophical method, ethics, and perception.” As a general description, the only reservation that can be felt about this remark is that it would be more accurate to add epistemology as a fourth main topic. Moore obviously grappled in a variety of ways with the problems raised by scepticism. Now, it might be that White included epistemology under the title of ‘perception’, and it is, indeed, not uncommon to think of the name ‘philosophy of perception’ as covering epistemology. But another—and, I think, more likely—possibility is that White underestimated Moore’s epistemological concerns, perhaps because when White was writing a number of Moore’s essays on the subject were not widely known (or, at least, not known to White).
Austin on the Philosophy of Perception
Authors: Snowdon Paul F
Published: July 2024

One way to respond, today, to the work of Austin is to take an idea he had and to build on it, or, perhaps, to take an idea that Austin generated in others and to build on that, or, perhaps, to criticize ideas with these Austinian origins. But I suspect that readers of the volume in which this chapter first appeared (Garvey 2014) also share an interest in achieving what one might call an understanding and assessment of Austin himself as a philosopher. Putting it in a rather blunt way, we can ask: what major contributions did Austin make to philosophy? I shall of course only look at one area, as indicated in my title. The tone of this paper will be historical, general, loose, and to some extent speculative. But I hope to assemble some evidence that might influence how one sees his work, and through that, Austin himself.
Wittgenstein and the Possibility of Meaning
Authors: Miller Alexander
Published: July 2024

Inspired by Ludwig Wittgenstein’s later philosophy, this book develops a new, non-reductionist, response to the sceptical argument about meaning famously developed in Saul Kripke’s book Wittgenstein on Rules and Private Language. It begins by outlining an intuitive notion of following a rule, explaining its relationship to the notions of linguistic meaning and intentional content. It then gives an outline and development of Kripke’s Wittgenstein’s sceptical argument, going into detail on the arguments against reductive dispositional accounts of meaning. It also explains Kripke’s Wittgenstein’s objections to non-reductionist views which take semantic and intentional facts to be primitive and sui generis and argues against views – such as error theories and forms of non-factualism – which attempt to respond to the argument by conceding that there are no meaning facts. The position advocated in the book emerges from a response to recent arguments developed by Paul Boghossian (“The Inference Problem”) and Crispin Wright (“The Minor Premise Problem”) which appear to imply that rule-following and competent language use are impossible even if we assume that Kripke’s challenge has been met. A reply to Boghossian and Wright is then developed via a new account of Wittgenstein’s remarks on the notion of “following a rule blindly” or “blind rule-following” that connects it to the Wittgensteinian idea that there is a way of following a rule that does not involve interpretation. In turn, this is used to generate a response to Kripke: understanding an expression is a matter of having an intention to exercise one’s ability to use it in accord with its meaning or correctness condition.
Boghossian and Wright on Blind Rule-Following
Authors: Miller Alexander
Published: July 2024

This chapter outlines arguments by Paul Boghossian (the “Inference Problem”) and Crispin Wright (the “Minor Premise Problem”). According to these arguments, even if we have a plausible non-reductionist response to Kripke’s Wittgenstein’s sceptical challenge to the satisfaction of the (Acceptance) condition in the ACER model of rule-following, there are additional problems concerning the (Explanation) and (Rationalization) conditions. These additional problems threaten the idea that rule-following, or linguistic competence, are possible. The chapter also explains some of the ideas necessary for an understanding of the problems, in particular the nature of Wittgenstein’s attack on the Augustinian picture of the relationship between thought and language.