bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing Outcomes after Oncoplastic Breast Reduction and Breast Reduction for Benign Macromastia
Authors: Marano Andrew A. , Grover Karan , Peysakhovich Anya , Lin Alexandra J. , Castillo Wendy , Rohde Christine H.
Published: January 2022

Background:

Oncoplastic breast reconstruction improves cosmetic outcomes when compared to standard breast conservation therapy alone. The authors studied whether tailoring a breast reduction to a cancer resection affects complication rates by comparing (1) outcomes between oncoplastic and benign macromastia patients and (2) complication rates between the cancer side and the symmetrizing side of an oncoplastic reduction.

Methods:

A retrospective chart review was performed on female patients who underwent either oncoplastic or benign breast reduction over 9 years by a single surgeon. Patient demographics, intraoperative data, and postoperative outcomes were gathered from the electronic medical record. Chi-square and t tests were performed when appropriate to determine significance.

Results:

Of the 211 patients included in the study, 62 (29.4 percent) underwent oncoplastic breast reduction and 149 (70.6 percent) underwent breast reduction for benign macromastia. Total resection weight was greater in the benign group (p = 0.00). There was a higher rate of loss of nipple sensation in the oncoplastic group (p = 0.005) but no differences in any other complication. There was a higher complication rate in the oncologic breast when compared to the symmetrizing breast within the oncoplastic cohort (p = 0.039), but no differences in the rates of individual complications.

Conclusions:

Although the loss of nipple sensation was increased in patients undergoing oncoplastic breast reduction, all other outcomes were not significantly different between the two groups. The authors’ findings indicate that oncoplastic breast reduction can be performed with a safety profile similar to that of a standard breast reduction.

CLINICAL QUESTION/LEVEL OF EVIDENCE:

Therapeutic, III.
American Society of Plastic Surgeons Evidence-Based Clinical Practice Guideline Revision: Reduction Mammaplasty
Authors: Perdikis Galen , Dillingham Claire , Boukovalas Stefanos , Ogunleye Adeyemi A. , Casambre Francisco , Dal Cin Arianna , Davidson Caryn , Davies Claire C. , Donnelly Katelyn C. , Fischer John P. , Johnson Debra J. , Labow Brian I. , Maasarani Samantha , Mullen Kyle , Reiland Juliann , Rohde Christine , Slezak Sheri , Taylor Anne , Visvabharathy Vidya , Yoon-Schwartz Diana
Published: January 2022

A multidisciplinary work group involving stakeholders from various backgrounds and societies convened to revise the guideline for reduction mammaplasty. The goal was to develop evidence-based patient care recommendations using the new American Society of Plastic Surgeons guideline methodology. The work group prioritized reviewing the evidence around the need for surgery as first-line treatment, regardless of resection weight or volume. Other factors evaluated included the need for drains, the need for postoperative oral antibiotics, risk factors that increase complications, a comparison in outcomes between the two most popular techniques (inferior and superomedial), the impact of local anesthetic on narcotic use and other nonnarcotic pain management strategies, the use of epinephrine, and the need for specimen pathology. A systematic literature review was performed, and an established appraisal process was used to rate the quality of relevant scientific research (Grading of Recommendations Assessment, Development and Evaluation methodology). Evidence-based recommendations were made and strength was determined based on the level of evidence and the assessment of benefits and harms.
Impact of Heroin and HIV on Gut Integrity and Immune Activation
Authors: Hileman Corrilynn O. , Bowman Emily R. , Gabriel Janelle , Kettelhut Aaren , Labbato Danielle , Smith Cheryl , Avery Ann , Parran Theodore , Funderburg Nicholas , McComsey Grace A.
Published: January 2022

Background:

Altered gut integrity is central to HIV-related immune activation. Opioids may promote similar changes in gut permeability and/or increase systemic inflammation, potentially augmenting processes already occurring in people with HIV (PWH).

Setting:

Urban hospital systems in Cleveland, Ohio, and surrounding communities.

Methods:

This is a prospectively enrolled, cross-sectional study including people with and without HIV using heroin and people with and without HIV who have never used heroin, matched by age, sex, and CD4+ T-cell count (PWH only) to compare markers of gut integrity, microbial translocation, systemic inflammation, and immune activation.

Results:

A total of 100 participants were enrolled. Active heroin use was associated with higher concentrations of lipopolysaccharide-binding protein (LBP), beta-D-glucan (BDG), high-sensitivity C-reactive protein (hsCRP), soluble tumor necrosis factor-α-receptors I and II, soluble CD163, inflammatory monocytes, and activated CD4+ lymphocytes in adjusted models. HIV status tended to modify the effect between heroin use and LBP, BDG, hsCRP, patrolling monocytes, and activated CD4+ lymphocytes (P < 0.15 for interactions); however, it was not as expected. The effect of heroin on these markers (except patrolling monocytes) was greatest among those without HIV rather than among those with HIV.

Conclusions:

Heroin use is associated with heightened microbial translocation, systemic inflammation, and immune activation. Concurrent HIV infection in virologically suppressed individuals does not seem to substantially worsen the effects heroin has on these markers.
Reproducibility of Automated Breast Ultrasonography and Handheld Ultrasonography for Breast Lesion Size Measurement
Authors: Park Ko Woon , Ko Eun Young , Park Surin , Han Boo-Kyung , Ko Eun Sook , Choi Ji Soo , Kwon Mi-ri
Published: January 2022

The purpose of our study was to evaluate the reproducibility of size measurement of breast lesions using automated breast ultrasonography (ABUS) compared with that with handheld ultrasonography (HHUS). Three breast radiologists performed HHUS and measured the lesions size in 2 different phantoms: lesions with various shape, size, and same stiffness (phantom 1) and lesions with same shape, size, and various stiffness (phantom 2). After 1 month, the same radiologists measured the lesion size of the same breast phantoms in the images obtained using ABUS. We evaluated interobserver variability between 3 radiologists in ABUS and HHUS, and intraobserver variability of radiologists between ABUS and HHUS. Intraclass correlation coefficient (ICC) was used in statistical analysis. The measured size of lesions on HHUS was slightly larger than that on ABUS in both phantom 1 and 2, although not statistically significant (P = 0.314, P = 0.858). There were no significant differences in size measurements between the radiologists' measurements and the reference size in phantom 2 (P = 0.862). The ICCs for the interobserver agreement between the 3 radiologists were 0.98 to 0.99 on ABUS and 0.99 to 1.00 on HHUS, respectively. The ICCs for the intraobserver agreement between ABUS and HHUS were 0.97 to 0.97 in phantom 1 and 0.98 to 0.99 in phantom 2. In conclusion, ABUS showed excellent interobserver and intraobserver agreement with HHUS in measuring size of the lesions, regardless of shape, size, and stiffness. Therefore, ABUS mixed with HHUS can be used reliably in following up breast lesions size.
Polyorchidism
Authors: Aitharaju Varun , Drevna David W. , Barr Richard G.
Published: January 2022

Polyorchidism, a very rare congenital anomaly, refers to the presence of more than 2 testes. It is often associated with many other pathologies including cryptorchidism, varicocele, testicular malignancy, and inguinal hernias.

In this report, we describe a 40-year-old man who presented with an intermittently painful left groin, initially appearing as inguinal hernia. On ultrasound examination, a supernumerary testes and epididymis were found in the inguinal canal. The testes appeared sonographically normal with no evidence of associated pathologies. There was no evidence of an inguinal hernia containing fat or bowel.

Ultrasound is essential in first-line diagnosis and classification of polyorchidism. Color Doppler ultrasound and magnetic resonance imaging can be used to clarify findings if sonographic images are inconclusive. We also review relevant literature as it pertains to classification, embryology, and treatment options. Patient treatment is based on imaging findings; if associated pathologies or malignancy is suspected, aggressive treatment such as surgical excision may be necessary. Otherwise, conservative treatment may be all that is needed.
Evaluation of Diaphragm Thickness and Stiffness Using Ultrasound and Shear-Wave Elastography
Authors: Şendur Halit Nahit , Cerit Mahi Nur , Şendur Aylin Billur , Özhan Oktar Suna , Yücel Cem
Published: January 2022

The purposes of this study are to measure the thickness and stiffness of diaphragm in association with the respiratory cyclus and to assess the reproducibility of these measurements. Forty individuals who are volunteered for participating diaphragm evaluation were included in the study. Two radiologists with 14 and 15 years of experiences in abdominal ultrasound performed all examinations independently. Furthermore, 8 chronic obstructive pulmonary disease (COPD) patients were examined by only the first radiologist. Gray scale and shear-wave elastography imaging of only the right hemidiaphragm of all participants were performed. Thickness and stiffness of diaphragm were measured at the peak inspiration and end expiration phases. Intraclass correlation coefficients test was used to assess the interobserver agreement. The thickness and stiffness of diaphragm significantly increased with inspiration (P < 0.001). The mean ± SD stiffness of diaphragm in peak inspiration and end expiration phases was 51.84 ± 16.83 kPa and 38.49 ± 9.42 kPa, respectively, for the first radiologist and 49.61 ± 13.83 kPa and 37.52 ± 10.71 kPa, respectively, for the second radiologist. Intraclass correlation coefficient values for diaphragm stiffness were 0.667 and 0.736 in peak inspiration and end expiration phases, respectively. In COPD patients, there was no significant difference between stiffness measurements of respiratory phases. In conclusion, the current study revealed that diaphragm thickness and stiffness increase at inspiration, and these measurements are slightly more reproducible at the end of expiration. However, diaphragm stiffness changes between respiratory phases may not be valid for COPD patients, and this may be related to loss of force-generating capacity of diaphragm in COPD patients.
Role of Apolipoprotein E in the Clinical Profile of Atypical Parkinsonian Syndromes
Authors: Nasri Amina , Sghaier Ikram , Gharbi Alya , Mrabet Saloua , Ben Djebara Mouna , Gargouri Amina , Kacem Imen , Gouider Riadh
Published: January 2022

Introduction:

Atypical Parkinsonian syndromes (APS) encompass a spectrum of neurodegenerative diseases including dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal syndrome (CBS). The effects of the Apolipoprotein E (APOE) gene on APS clinical features are controversial and understudied in several populations. We aimed to explore the influence of APOE genotype on clinical features in an APS Tunisian cohort.

Methods:

We included clinically diagnosed APS patients genotyped for APOE, and analyzed the clinical and APOE genotype associations.

Results:

A total of 328 APS patients were included, comprising 184 DLB, 58 PSP, 49 MSA, and 37 CBS. Significant differences in initial Mini-Mental State Examination and Frontal Assessment Battery scores according to APOE genotypes (P=0.05 and 0.0048) were found. Executive dysfunction (P=0.026) disorientation (P=0.025), and hallucinations (P<0.001) were more pronounced among APOE-ɛ4 carriers particularly in DLB. Memory disorders were also correlated to APOE-ɛ4 allele (P=0.048) and were more frequent among DLB and PSP carriers. Depression was associated to APOE-ε4 (P=0.042), more markedly in APOE-ε4-CBS and MSA carriers.

Conclusions:

Our findings suggested a role of APOE-ε4 in defining a more altered cognitive phenotype with variable degrees across subgroups in APS patients, especially in DLB carriers. This effect mainly concerned executive, memory and orientation functions as well as hallucinations.
Quantifying the dynamics of nearly 100 years of dominance hierarchy research
Authors: Hobson Elizabeth A.
Published: January 2022

Dominance hierarchies have been studied for almost 100 years. The science of science approach used here provides high-level insight into how the dynamics of dominance hierarchy research have shifted over this long timescale. To summarize these patterns, I extracted publication metadata using a Google Scholar search for the phrase ‘dominance hierarchy’, resulting in over 26 000 publications. I used text mining approaches to assess patterns in three areas: (1) general patterns in publication frequency and rate, (2) dynamics of term usage and (3) term co-occurrence in publications across the history of the field. While the overall number of publications per decade continues to rise, the percent growth rate has fallen in recent years, demonstrating that although there is sustained interest in dominance hierarchies, the field is no longer experiencing the explosive growth it showed in earlier decades. Results from title term co-occurrence networks and community structure show that the different subfields of dominance hierarchy research were most strongly separated early in the field’s history while modern research shows more evidence for cohesion and a lack of distinct term community boundaries. These methods provide a general view of the history of research on dominance hierarchies and can be applied to other fields or search terms to gain broad synthetic insight into patterns of interest, especially in fields with large bodies of literature.

This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.
DomArchive: a century of published dominance data
Authors: Strauss Eli D. , DeCasien Alex R. , Galindo Gabriela , Hobson Elizabeth A. , Shizuka Daizaburo , Curley James P.
Published: January 2022

Dominance behaviours have been collected for many groups of animals since 1922 and serve as a foundation for research on social behaviour and social structure. Despite a wealth of data from the last century of research on dominance hierarchies, these data are only rarely used for comparative insight. Here, we aim to facilitate comparative studies of the structure and function of dominance hierarchies by compiling published dominance interaction datasets from the last 100 years of work. This compiled archive includes 436 datasets from 190 studies of 367 unique groups (mean group size 13.8, s.d. = 13.4) of 135 different species, totalling over 243 000 interactions. These data are presented in an R package alongside relevant metadata and a tool for subsetting the archive based on biological or methodological criteria. In this paper, we explain how to use the archive, discuss potential limitations of the data, and reflect on best practices in publishing dominance data based on our experience in assembling this dataset. This archive will serve as an important resource for future comparative studies and will promote the development of general unifying theories of dominance in behavioural ecology that can be grounded in testing with empirical data.

This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.
The establishment and maintenance of dominance hierarchies
Authors: Tibbetts Elizabeth A. , Pardo-Sanchez Juanita , Weise Chloe
Published: January 2022

Animal groups are often organized hierarchically, with dominant individuals gaining priority access to resources and reproduction over subordinate individuals. Initial dominance hierarchy formation may be influenced by multiple interacting factors, including an animal's individual attributes, conventions and self-organizing social dynamics. After establishment, hierarchies are typically maintained over the long-term because individuals save time, energy and reduce the risk of injury by recognizing and abiding by established dominance relationships. A separate set of behaviours are used to maintain dominance relationships within groups, including behaviours that stabilize ranks (punishment, threats, behavioural asymmetry), as well as signals that provide information about dominance rank (individual identity signals, signals of dominance). In this review, we describe the behaviours used to establish and maintain dominance hierarchies across different taxa and types of societies. We also review opportunities for future research including: testing how self-organizing behavioural dynamics interact with other factors to mediate dominance hierarchy formation, measuring the long-term stability of social hierarchies and the factors that disrupt hierarchy stability, incorporating phenotypic plasticity into our understanding of the behavioural dynamics of hierarchies and considering how cognition coevolves with the behaviours used to establish and maintain hierarchies.

This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.
Dominance in humans
Authors: Chen Zeng Tian , Cheng Joey T. , Henrich Joseph
Published: January 2022

Dominance captures behavioural patterns found in social hierarchies that arise from agonistic interactions in which some individuals coercively exploit their control over costs and benefits to extract deference from others, often through aggression, threats and/or intimidation. Accumulating evidence points to its importance in humans and its separation from prestige—an alternate avenue to high status in which status arises from information (e.g. knowledge, skill, etc.) or other non-rival goods. In this review, we provide an overview of the theoretical underpinnings of dominance as a concept within evolutionary biology, discuss the challenges of applying it to humans and consider alternative theoretical accounts which assert that dominance is relevant to understanding status in humans. We then review empirical evidence for its continued importance in human groups, including the effects of dominance—independently of prestige—on measurable outcomes such as social influence and reproductive fitness, evidence for specialized dominance psychology, and evidence for gender-specific effects. Finally, because human-specific factors such as norms and coalitions may place bounds on purely coercive status-attainment strategies, we end by considering key situations and contexts that increase the likelihood for dominance status to coexist alongside prestige status within the same individual, including how: (i) institutional power and authority tend to elicit dominance; (ii) dominance-enhancing traits can at times generate benefits for others (prestige); and (iii) certain dominance cues and ethology may lead to mis-attributions of prestige.

This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.
The human bile salt sodium deoxycholate induces metabolic and cell envelope changes in Salmonella Typhi leading to bile resistance
Authors: Olivar-Casique Isaac B. , Medina-Aparicio Liliana , Mayo Selena , Gama-Martínez Yitzel , Rebollar-Flores Javier E. , Martínez-Batallar Gabriel , Encarnación Sergio , Calva Edmundo , Hernández-Lucas Ismael
Published: January 2022

Introduction.

Salmonella enterica

serovar Typhi (S. Typhi) is the etiological agent of typhoid fever. To establish an infection in the human host, this pathogen must survive the presence of bile salts in the gut and gallbladder.

Hypothesis.
S. Typhi uses multiple genetic elements to resist the presence of human bile.

Aims. To determine the genetic elements that S. Typhi utilizes to tolerate the human bile salt sodium deoxycholate.

Methodology. A collection of S. Typhi mutant strains was evaluated for their ability to growth in the presence of sodium deoxycholate and ox-bile. Additionally, transcriptomic and proteomic responses elicited by sodium deoxycholate on S. Typhi cultures were also analysed.

Results. Multiple transcriptional factors and some of their dependent genes involved in central metabolism, as well as in cell envelope, are required for deoxycholate resistance.

Conclusion. These findings suggest that metabolic adaptation to bile is focused on enhancing energy production to sustain synthesis of cell envelope components exposed to damage by bile salts.
Durability and cross-reactivity of SARS-CoV-2 mRNA vaccine in adolescent children
Authors: Burns Madeleine D , Boribong Brittany P , Bartsch Yannic C , Loiselle Maggie , Davis Jameson P , Lima Rosiane , Edlow Andrea G , Fasano Alessio , Alter Galit , Yonker Lael M
Published: January 2022

Emergent SARS-CoV-2 variants and waning humoral immunity in vaccinated individuals have resulted in increased infections and hospitalizations. Children are not spared from infection nor complications of COVID-19, and the recent recommendation for boosters in individuals ages 12 years or older calls for broader understanding of the adolescent immune profile after mRNA vaccination. We tested the durability and cross-reactivity of anti-SARS-CoV-2 serologic responses over a six-month time course in vaccinated adolescents against the SARS-CoV-2 wild type and Omicron antigens. Serum from 77 adolescents showed that anti-Spike antibodies wane significantly over 6 months. After completion of a two-vaccine series, cross-reactivity against Omicron-specific receptor-binding domain (RBD) was seen. Evidence of waning mRNA-induced vaccine immunity underscores vulnerabilities in long-term pediatric protection against SARS-CoV-2 infection, while cross-reactivity highlights the additional benefits of vaccination. Characterization of adolescent immune signatures post-vaccination will inform guidance on vaccine platforms and timelines, and ultimately optimize immunoprotection of children.
Genetic background of grey matter brain networks related to attention-deficit/hyperactivity disorder
Authors: Schoenmacker Gido H. , Duan Kuaikuai , Rootes-Murdy Kelly , Jiang Wenhao , Hoekstra Pieter J. , Hartman Catharina A. , Oosterlaan Jaap , Hoogman Martine , Franke Barbara , Turner Jessica A. , Liu Jingyu , Claassen Tom , Heskes Tom , Buitelaar Jan K. , Vásquez Alejandro Arias
Published: January 2022

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder and is associated with structural grey matter differences in the brain. We investigated the genetic background of some of these brain differences in a sample of 899 adults and adolescents consisting of individuals with ADHD and healthy controls. Previous work in an overlapping sample identified three ADHD-related grey matter brain networks located in areas of the superior, middle, and inferior frontal gyrus as well as the cerebellar tonsil and culmen. We associated these brain networks with protein coding genes using a statistical stability selection approach. We identified ten genes, the most promising of which were NR3C2, TRHDE, SCFD1, GNAO1, and UNC5D. These genes are expressed in brain and linked to neuropsychiatric disorders including ADHD. With our results we aid in the growing understanding of the aetiology of ADHD from genes to brain to behaviour.
The Dynamics of SARS-CoV-2 Infectivity with Changes in Aerosol Microenvironment
Authors: Oswin Henry P. , Haddrell Allen E. , Otero-Fernandez Mara , Mann Jamie F.S. , Cogan Tristan A. , Hilditch Tom , Tian Jianghan , Hardy Dan , Hill Darryl J. , Finn Adam , Davidson Andrew D. , Reid Jonathan P.
Published: January 2022

Understanding the factors that influence the airborne survival of viruses such as SARS-CoV-2 in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets (∼5-10µm equilibrated radius) over timescales spanning from 5 seconds to 20 minutes using a novel instrument to probe survival in a small population of droplets (typically 5-10) containing ∼1 virus/droplet. Measurements of airborne infectivity change are coupled with a detailed physicochemical analysis of the airborne droplets containing the virus. A decrease in infectivity to ∼10 % of the starting value was observable for SARS-CoV-2 over 20 minutes, with a large proportion of the loss occurring within the first 5 minutes after aerosolisation. The initial rate of infectivity loss was found to correlate with physical transformation of the equilibrating droplet; salts within the droplets crystallise at RHs below 50% leading to a near instant loss of infectivity in 50–60% of the virus. However, at 90% RH the droplet remains homogenous and aqueous, and the viral stability is sustained for the first 2 minutes, beyond which it decays to only 10% remaining infectious after 10 minutes. The loss of infectivity at high RH is consistent with an elevation in the pH of the droplets, caused by volatilisation of CO2from bicarbonate buffer within the droplet. Three different variants of SARS-CoV-2 were compared and found to have a similar degree of airborne stability at both high and low RH.

Significance

The aerosol microenvironment is highly dynamic exposing pathogens, such as the SARS-CoV-2 virus when exhaled in respiratory aerosol, to extreme conditions of solute concentration, pH and evaporative cooling. Yet surviving this environment is a key step in the transmission of such pathogens. Understanding the impact that airborne transport has on pathogens and the influence of environmental conditions on pathogen survival can inform the implementation of strategies to mitigate the spread of diseases such as COVID-19. We report changes in the infectivity of the airborne virus over timescales spanning from 5 s to 20 minutes and demonstrate the role of two microphysical processes in this infectivity loss: particle crystallisation and aerosol droplet pH change.
Population-split-based risk assessment model of venous thromboembolism in Chinese medical inpatients
Authors: Wang Xin , Yang Yu-Qing , Hong Xin-Yu , Liu Si-Hua , Li Jian-Chu , Chen Ting , Shi Ju-Hong
Published: January 2022

Abstracts

Objective

Inpatients with high risk of venous thromboembolism (VTE) usually face serious threats to their health and economic conditions. Many studies using machine learning (ML) models to predict VTE risk neglected an important statistical phenomenon, ‘fuzzy feature’, and achieved inferior results. Considering the effect of ‘fuzzy feature’, our study aims to develop a VTE risk assessment model suitable for Chinese medical inpatients.

Materials and Methods

Inpatients in the medical department of Peking Union Medical College Hospital (PUMCH) from January 2014 to June 2016 were collected. A new ML VTE risk assessment model was built through population splitting. First patients were classified into different groups based on values of VTE risk factors, then trustless groups were filtered out, and finally ML models were built on training data in unit of groups. Predictive performances of our method, five traditional ML models, and the Padua model were compared.

Results

The ‘fuzzy feature’ was verified on the whole dataset. Compared with the Padua model, the proposed model showed higher sensitivities and specificities on training data, and higher specificities and similar sensitivities on test data. Standard deviations of predictive validity of five ML models were larger than the proposed model.

Discussion

The proposed model was the only one which showed advantages on both sensitivity and specificity over Padua model. Its robustness was better than traditional ML models.

Conclusion

This study built a population-split-based ML model of VTE for Chinese medical inpatients and it may help clinicians stratify VTE risk and guide prevention more efficiently.
Omicron Impact in India: Analysis of the Ongoing COVID-19 Third Wave Based on Global Data
Authors: Ranjan Rajesh
Published: January 2022

The Omicron variant of coronavirus has caused major disruptions worldwide with countries struggling to manage the overwhelming number of infections. Omicron is found to be significantly more transmissible compared to its predecessors and therefore almost every impacted country is exhibiting new infection peaks than seen earlier. In this work, we analyze the global statistics of Omicron-impacted countries including South Africa, the United Kingdom, the United States, France, and Italy to quantitatively estimate the intensity and severity of recent waves. Next, these statistics are used to estimate the impact of Omicron in India, which is experiencing an intense third wave of COVID-19 since 28 Dec., 2021. The rapid surge in the daily number of infections, comparable to the global trends, strongly suggests the dominance of the Omicron variant in infections in India. The logarithmic regression suggests the early growth rate of infections in this wave is nearly four times that in the second wave. Another notable difference in this wave is the relatively concurrent arrival of outbreaks all across the country; the effective reproduction number (Rt) although has significant variations among different regions. The test positivity rate (TPR) also displays a rapid growth in the last 10 days in several states. Preliminary estimates with the Susceptible-Infected-Removed (SIR) model suggest that the peak in India to occur in late January 2022 with a caseload exceeding that in the second wave. Although global Omicron trends, as analyzed in this work, suggest a decline in case fatality rate and hospitalizations compared to Delta, a sudden accumulation of active infections can potentially choke the already stressed healthcare infrastructure for the next few weeks.
Epidemiology of SARS-CoV-2 infection in Italy using real-world data: methodology and cohort description of the second phase of web-based EPICOVID19 study
Authors: Adorni Fulvio , Jesuthasan Nithiya , Perdixi Elena , Sojic Aleksandra , Giacomelli Andrea , Noale Marianna , Trevisan Caterina , Franchini Michela , Pieroni Stefania , Cori Liliana , Mastroiannii Claudio M , Bianchi Fabrizio , Incalzi Raffaele Antonelli , Maggi Stefania , Galli Massimo , Prinelli Federica
Published: January 2022

Digital technologies have been extensively employed in response to the SARS-CoV-2 pandemic worldwide. This study describes the methodology of the two-phase internet-based EPICOVID19 survey, and the characteristics of the adult volunteers respondents who lived in Italy during the first (April - May 2020) and the second wave (January - February 2021) of the epidemic. Validated scales and ad-hoc questionnaires were used to collect socio-demographic, medical and behavioural characteristics, as well as information on COVID-19. Among those who provided email addresses during phase I (105,355), 41,473 participated in phase II (mean age 50.7 years ± 13.5 SD, 60.6% females). After a median follow-up of ten months, 52.8% had undergone naso-pharyngeal swab (NPS) testing and 13.2% had positive result. More than 40% had undergone serological test (ST) and 11.9% were positive. Out of the 2,073 participants with at least one positive ST, 72.8% had only negative results from NPS or never performed it. These results indicate that a large fraction of individuals remained undiagnosed, possibly contributing to the spread of the virus in the community. Participatory online surveys offer a unique opportunity to collect relevant data at individual level from large samples during confinement.
Subtypes of early childhood caries predict future caries experience
Authors: Gormley Alexander , Haworth Simon , Simancas-Pallares Miguel , Holgerson Pernilla Lif , Esberg Anders , Shrestha Poojan , Divaris Kimon , Johansson Ingegerd
Published: January 2022

Objectives

To test whether postulated subtypes of early childhood caries (ECC) are predictive of subsequent caries experience in a population-based cohort of Swedish children.

Methods

The study included children aged between 3 and 5 years at study entry with dental records available for at least 5 years of follow-up. Dental record data were retrieved from the Swedish Quality Registry for Caries and Periodontal disease (SKaPa) for the initial and follow-up visits. Participants who had ECC at study entry were assigned to one of five ECC subtypes (termed classes 1 to 5) using latent class modelling of tooth surface-level caries experience. Subsequent experience of caries was assessed using the decayed, missing, and filled surfaces indices (dmfs/DMFS) at follow-up visits, and compared between ECC subtypes using logistic and negative binomial regression modelling.

Results

The study included 128,355 children who had 3 or more dental visits spanning at least 5 years post baseline. Of these children, 31,919 had caries at the initial visit. Baseline ECC subtype was associated with differences in subsequent disease experience. As an example, 83% of children who had a severe form of ECC at age 5 went on to have caries in the permanent dentition by the end of the study, compared to 51% of children who were caries-free at age 5 (adjusted odds ratio of 4.9 for new disease at their third follow-up).

Conclusions

ECC subtypes assigned at a baseline visit are associated with differences in subsequent caries experience in both primary and permanent teeth. This suggests that the development and future validation of an ECC classification can be used in addition to current prediction tools to help identify children at high risk of developing new caries lesions throughout childhood and adolescence.
A mixed-method approach to assess users' intention to use mobile health (mHealth) using PLS-SEM and fsQCA
Authors: Hasan Najmul , Bao Yukun
Published: January 2022

Purpose

Despite the enormous potential of mobile health (mHealth), identifying the asymmetric relationship among the predictors towards intention to use (ITU) of mHealth tends to remain unresolved. This study aims to investigate the predictors and their asymmetric effects on ITU of mHealth through patients and healthcare professionals.

Design/methodology/approach

An integrated information systems (IS) model with four additional constructs has been developed to analyze symmetric and asymmetric effects on ITU of mHealth. An exploratory survey on 452 mHealth users with prior experience was conducted to evaluate the model using a mixed-method approach including partial least squares-based structural equation modeling (PLS-SEM) and fuzzy-set qualitative comparative analysis (fsQCA) technique.

Findings

The findings show that facilitating conditions, personal awareness building, perceived enjoyment, effort expectancy and perceived usefulness have predictive power for ITU of mHealth. In contrast, fsQCA reveals four more alternative solutions, including the main drivers explored by PLS-SEM. The results indicate that various conditions that were not crucial in PLS-SEM analysis are shown to be sufficient conditions in fsQCA.

Research limitations/implications

This study contributes to theory by integrating self-actualization factors (i.e. personal awareness building, patients as decision support unit) into the IS model. And practically, this study makes an essential contribution to users' ITU of mHealth, enabling relevant stakeholders to build strategies to implement mHealth successfully.

Originality/value

While mHealth has revolutionized healthcare and the prior literature only showed linear relationships, this empirical study revealed asymmetrical relationships among the determinants of ITU of mHealth. Thus, this study extends to the growing body of literature on the use of mHealth technology in the least developing nation.
Benchmarking the failure assessment of perishable product supply chain using fault tree approach: insights from apple case study of India
Authors: Bhardwaj Manisha , Agrawal Rajat
Published: January 2022

Purpose

The purpose of this paper is to facilitate perishable product supply chain (PPSC) managers and practitioners to assess PPSC failure events. The paper proposed fault tree methodology for assessing failures associated with PPSC for evaluating the performance in terms of effective PPSC management adoption.

Design/methodology/approach

Initially, different failure events were identified from literature and semi-structured interviews from experts. Fault tree model was developed from the identified failure events. Probability of failure events was calculated using Poisson distribution based on the annual reports and interviews conducted from experts. Further, qualitative analysis – minimum cut sets (MCSs), structural importance coefficient (SIC) – and quantitative analysis – Birnbaum importance measure (BIM), criticality importance factor (CIF) and diagnosis importance factor (DIF) – were performed for ranking of failure events. In this study, fault tree development and analysis were conducted on apple supply chain to present the authenticity of this method for failure analysis.

Findings

The findings indicate that the failure events, given as failure at production and procurement (A2), that is, involvement of middleman (BE3), handling and packaging failure (BE4) and transportation failure (A3), hold the highest-ranking scores in analysis of PPSC using fault tree approach.

Originality/value

This research uses the modularization approach for evaluation of failure events of PPSC. This paper explores failures related to PPSC for efficient management initiatives in apple supply chain context. The paper also provides suggestion from managerial perspective with respect to each failure event.
Eyes open and hands on: market knowledge and marketing capabilities in export markets
Authors: Hoque Mohammad Tayeenul , Ahammad Mohammad Faisal , Tzokas Nikolaos , Tarba Shlomo , Nath Prithwiraj
Published: January 2022

Purpose

Drawing on the knowledge-based view of the firm (KBV) and Dynamic Marketing Capabilities (DMC), this paper examines the role of key internationalization knowledge absorption processes as learning strategies, namely market exploitation and market exploration in enabling internationalization knowledge absorption in export-oriented firms involved in manufacturing goods or producing electrical/engineering products.

Design/methodology/approach

The data were gathered via a cross-sectional survey using a questionnaire (i.e. n = 315) on a sample of Bangladeshi manufacturing firms exporting in US and European markets.

Findings

The findings suggest that an export firm's internationalization absorption strategies are positively associated with export performance. The authors also found that the mediator, DMC, strengthened the relationship between knowledge absorption and export performance. Moreover, the findings of moderated mediation model revealed that the direct and indirect effects of market exploitation on export performance are more prevalent when competitive intensity is low. While competitive intensity is high, the direct and indirect effects of market exploration on export performance are more prevalent.

Practical implications

By introducing a higher-level dynamic marketing capability approach and linking it to ambidexterity constructs (learning though exploration and exploitation), export business professionals should appreciate the full spectrum of mid-level marketing capabilities they need to develop alongside their exploration and exploitation strategies to improve their export performance. This study directs attention to the competitive intensity conditions the exporting firm is facing. When export business professionals are faced with high-level of competitive intensity in the market, they should establish a clear focus on their exploration learning strategies if they wish to enhance their export performance.

Originality/value

The authors contribute to two broad domains of literature: organizational learning and DMC strategy. The study results show that how the two components of international ambidexterity as organizational learning constructs (i.e. market exploration and exploitation) influence knowledge management processes within firms through a firm's possession of a fine configuration of higher-level marketing capability. This study also theoretically and empirically examines how higher-level DMC strategy can mediate the consequence of international knowledge absorption mechanism on firm export performance. From a practical perspective, this study provides useful lessons for exporting firms wishing to enhance their performance.
Happiness and pro-environmental consumption behaviors
Authors: Nguyen Hung Vu , Le Mai Thi Thu , Pham Chuong Hong , Cox Susie S.
Published: January 2022

Purpose

This paper employs the theoretical foundations for subjective well-being to examine the impacts of two underlying dimensions of subjective well-being (psychological well-being and social well-being) on pro-environmental consumption behaviors (PECBs). In this research, the moderating role of exposure to positive environmental messages on media in the relationship between subjective well-being and PECBs is also examined.

Design/methodology/approach

This research uses a quantitative research method with data collected from an online survey questionnaire posted in Facebook groups related to PECBs in Vietnam.

Findings

Psychological well-being and social well-being are found to be separate significant predictors of PECBs. More importantly, exposure to positive environmental messages on media was found to reinforce the impacts of psychological well-being on PECB but not moderate the relationship between social well-being and PECB.

Originality/value

This research offers a new insight for encouraging PECB from the perspective of subjective well-being. Different from the extant perspectives, which usually examine subjective well-being as a unidimensional antecedent of PECB, the authors highlight that subjective well-being can influence PECB in two separate dimensions. Moreover, this research extends existing literature by accentuating the role of exposure to environmental messages in the association between different types of social well-being and PECB.
Influencing factors of crude oil maritime shipping freight fluctuations: a case of Suezmax tankers in Europe–Africa routes
Authors: Chen Jihong , Zhao Renjie , Xiong Wenjing , Wan Zheng , Xu Lang , Zhang Weipan
Published: January 2022

Purpose

The paper aims to identify the contributors to freight rate fluctuations in the Suezmax tanker market; this study selected the refinery output, crude oil price, one-year charter rate and fleet development as the main influencing factors for the market analysis.

Design/methodology/approach

The paper used the vector error correction model to evaluate the degree of impact of each influencing factor on Suezmax tanker freight rates, as well as the interplay between these factors.

Findings

The conclusion and results were tested using the 20-year data from 1999 to 2019, and the methodology and theory of this paper were proved to be effective. Results of this study provide effective reference for scholars to find the law of fluctuations in Suezmax tanker freight rates.

Originality/value

This paper provides a decision-making support tool for tanker operators to cope with fluctuation risks in the tanker shipping market.
The emerging work system and strategy for skills transition in South Africa
Authors: Samuel Olorunjuwon Michael , Moagi Tshegofatso
Published: January 2022

Purpose

The rapidly emerging digital work system, accentuated by technological innovation, has dramatically changed the nature of skill-sets required for employees to perform their tasks effectively at the workplaces. This paper aims to examine the skills development strategies that organizations in South Africa are adopting in the transitioning of their respective workforces to fit the skills dynamics of the emerging work system.

Design/methodology/approach

The paper uses the interpretive qualitative research strategy to draw evidence from semi-structured interviews conducted on 38 respondents, using the thematic analytical process to derive themes embedded in the data set.

Findings

Based on the strength of data analysis, this paper identified two broad themes and six sub-themes that are critical for the transformation and transition of existing pool of skills for the emerging work system in South Africa.

Research limitations/implications

The research lacks ability to be generalized, which is a methodological limitation that is inherently associated with cross-sectional design and qualitative strategy in terms of causality and generalizability of findings.

Originality/value

The main value-add of this paper is the development of evidence-based research outcomes that provide both theoretical and practical framework for skills development and transition initiatives that are imperative for policy formulation. The paper responded to, and advanced the respective works of Hirschi (2017), Sharma et al. (2021) and Barley et al. (2017), by establishing the following strategic themes that are critical for skills development and transition mechanisms in the emerging work system: stakeholder relationship, media and public perception, learning organization, higher education system, continuous skills development and technology and job losses.
Country-level sustainability and cross-border banking flows
Authors: Avci Sureyya Burcu , Sungu-Esen Gözde
Published: January 2022

Purpose

This paper aims to investigate the association between country-level sustainability scores and cross-border bank-to-non-bank flows within countries.

Design/methodology/approach

The authors analyze cross-border banking flows into the real sector firms of 26 developed countries from 2006 to 2017. The authors use a dynamic panel ordinary least square along with an instrumental variable and a generalized method of moments regressions to test the relationship between country-level sustainability scores and cross-border banking flows. Additionally, the authors apply Fama-MacBeth cross-sectional regression and non-parametric portfolio tests to obtain robust results.

Findings

The impact of country-level sustainability scores on cross-border banking flows is positive and significant. This finding is consistent with the signaling theory, which states that a country’s sustainability score is a signal to attract more international fund flows. Notably, the authors deduce that environmental sustainability is more important than the social and governance pillars.

Practical implications

The findings indicate that the real sector firms located in countries having higher sustainability scores can receive more international bank flows. Consequently, policymakers should focus more on country-level sustainability investments to improve the financing of resident firms.

Social implications

Policymakers should focus more on country-level sustainability investments to improve the financing of resident firms.

Originality/value

To the best of the authors’ knowledge, no existing study has investigated the signaling function of country-level sustainability scores in the cross-border banking flow conjecture. By investigating this relationship for real sector firms, this study portrays how the non-banking sector can benefit from such a policy that promotes sustainable practices at the country level.