bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral treatment of hypokalemia with potassium chloride and propylene glycol in cows
Authors: Dabbir Bala Krishna Rao , Santimalla Venkata Siva Reddy , Rajavolu Srinivasulu Reddy
Published: September 2023

Hypokalemia is a fatal metabolic, pathological and induced disorder of Potassium, manifested by low serum levels generally encountered in lactating animals and during thermal-stress. Currently Potassium is given in normal saline intravenously and very slowly. This method is costly, risky and laborious. To study the effect of oral administration of 12 g of elemental Potassium and 200 ml of Propylene glycol orally in hypokalemic cows.

After estimating the serum level of potassium with Serum, analyzer, the effect of Nutri-Pot (A) containing 12 g of Potassium in 50-gram pouch and Nutri-Pot (B) containing 200 ml Propylene Glycol in 28 clinically hypokalemic cows was studied. Both A & B were mixed with 200 ml of drinking water and were slowly drenched and the second dose is repeated after 12 hours.

Out of 28 cows, 26 were recovered fully and returned to normal condition and milk production.

Combined drenching of Potassium and Propylene glycol was only the safest, most effective and economical method than administration through a balling gun and gelatin boluses or by ororuminal intubation. Or parenteral administration.
Введення в культуру in vitro і клональне мікророзмноження лаванди вузьколистої (Lavandula angustifolia Mill.)
Authors: Шляхтун І.С.
Published: September 2023

Лаванда вузьколиста – ефіроолійна культура, яка має широке комерційне застосування. Метою роботи було отримання ліній лаванди вузьколистої та розробка технології їх клонального мікророзмноження. В якості матеріалів дослідження використовували вирощені в умовах відкритого ґрунту комерційні сорти лаванди вузьколистої «Munstead» та «Ellagance Purple». Рослинний матеріал було простерилізовано двома методами і висаджено на поживні середовища з різним вмістом кінетину, для визначення впливу гормонів росту на морфогенез лаванди в умовах in vitro. Отримані результати вказують, що на регенераційну здатність тканин лаванди впливають склад поживного середовища, схема стерилізації експлантів та умови культивування in vitro.
Перспективи виробництва авіаційних біопалив в Україні
Authors: Желєзна Т.А. , Драгнєв С.В.
Published: September 2023

Розглянуто перспективи виробництва сталих авіаційних палив з вітчизняної біомаси.
Marking stages of REM and non-REM sleep using recurrent analysis
Authors:   Saratov State University, Emelyanova Elizaveta , Selskii Anton ,   Saratov State University
Published: September 2023

The purpose of this study — to develop a simple technique for labeling sleep stages according to EEG data obtained from half-somnography recordings. To test the work of the method, it will be applied to three groups of subjects: conditionally healthy, patients with Parkinson’s disease, patients with sleep apnea. Methods. In this work, to recognize sleep stages, we use the calculation of a recurrent indicator and its subsequent assessment. It is shown that the stages of REM (Rapid Eye Movement) and non-REM sleep demonstrate different values of the recurrent index. Results. Depending on the range in which the recurrent indicator falls, the stages of REM and non-REM sleep were determined for the subjects, according to their nightly polysomnographic records. For three groups of subjects, the average knowledge of the accuracy of the method was calculated, which for all groups exceeded 72.5%. Conclusion. It is shown that on the basis of recurrent analysis it is possible to create a simple and effective method for recognizing sleep stages. For patients with apnea, the average accuracy of the method is higher than for apparently healthy subjects, for whom, in turn, this value was higher than for patients with Parkinson’s disease. This can be explained by the fact that the variability in the group of statistical characteristics of sleep stages in patients with apnea is lower, and in patients with Parkinson’s disease is higher, compared with apparently healthy subjects.
Self-organization dynamics of charge carrier concentration in semiconductors due to the charge injection
Authors:   Samara University, Elisov Maksim
Published: September 2023

The purpose of this study is to investigate the phenomenon of self-organization of the dynamics of charge carriers in semiconductor structures. Investigate the basic model, give a numerical estimate for given parameters and propose its modification. Determine the dependence of the evaluation results on the control parameter. Consider the dynamics when the control parameter depends on time. Carry out theoretical analysis, numerical simulation and build graphs. Methods. In this paper, we investigate the possibilities and limitations of the basic model of generation-recombination dynamics in semiconductors, proposed earlier by other researchers. A modification of this model was proposed and considered. Results. Various types of charge carrier concentration dynamics are demonstrated.Theoretical analysis of the model was carried out. Numerical simulation has shown that for certain values of the control parameter, stable states are observed. Numerical estimates of the control parameter were obtained, phase portraits of the nonlinear equation were constructed, and the behavior of the dynamical system was considered when the control parameter is periodic. The extended model showed a qualitatively new behavior in comparison with the basic one. Conclusion. It is shown that charge dynamics in semiconductor structures can exhibit different behaviors. The patterns and estimates obtained are consistent with those obtained earlier. The results obtained can be verified experimentally and will be useful in the development of photo- and beta-voltaic devices.
Application of Pranic Agriculture to Improve Growth and Yield of Banana (Musa sp. var. Nanjangud Rasa Bale)-A Comparative Field Trial
Authors: Prasad K. Nagendra , Vinu V. , Jois Srikanth N.
Published: September 2023

Background: The projection of prana to soil, seeds and seedlings to enhance plant growth is referred to as Pranic Agriculture (PA). Methods: A field study was carried out to study the influence of PA on Banana var. (Musa sps. var. Nanjangud rasabale) growth for a duration of one year. Banana suckers and agricultural land were divided into two groups namely pranic and control in half acre. The land and suckers were treated with PA and were referred to as the pranic group, while non-pranic were referred to as the control group. Growth parameters (shoot length, shoot diameter, number of leaves, leaf length and leaf diameter) were evaluated on the 2nd, 4th, 6th, 8th, 10th and 12th months and statistically analyzed using repeated measure ANOVA. Fruit morphology and days to flowering were analyzed using a t-test. Result: For pranic group, shoot diameter (F = 9.407, p = 0.001), leaf length (F = 7.082, p = 0.003) and leaf diameter (F = 11.459, p = .000), flowering days (t = 3.39, P=.002), fruit characteristics like fruit bunch weight (t = 8.81, p = .000), total number of fruits in bunch (t = 9.20, p = .000), fruits weight (t = 7.48, p = .000), fruit length (t = 7.94, p = .000) enhanced considerably and the results were all significant when compared to control. Further studies are needed to find out the mechanism for the improved growth in the pranic group. This study will help the farmers to get higher yields and more income by using pranic agriculture.
INVENTARISASI JENIS VEGETASI POHON DI LABORATORIUM ALAM PENDIDIKAN BIOLOGI SEBAGAI RANCANGAN BUKU SAKU PADA MATERI KEANEKARAGAMAN HAYATI
Authors: Daryanes Febblina , Wulandari Sri , Fauziah Yuslim , Deswita Vina
Published: September 2023

The types of woody plants in the Nature Laboratory of Biology Education FKIP UNRI have not been completely recorded, besides that the results of observations can be used as a source of learning which is still very rare for teachers to develop pocket books. This study aims to inventory tree vegetation at the Nature Laboratory of Biology Education FKIP UNRI as a pocket book design on biodiversity material. The research was conducted in June-September 2021. This research is survey research and development research. Inventory of tree vegetation types using the roaming method. The development of a pocket book on biodiversity material uses the ADDIE development model. The inventory results show that there are 19 types of tree vegetation in the Biology Education Nature Laboratory, namely Alstonia scholaris. R. Br, Rhodamnia cinereal, Sizygium acuminatissimum, Terminalia catappa. L, Aporasa granularis, Blumeodendron kruzii, Maccaranga gigantean, Endospermum javanicum, Artocarpus elasticus, Ficus carica. L, Artocarpus heterophyllus, Calophyllum inophyllum. L, Vitex pinnata, Switenia macrophylla, Peronema canescens, Symplocos cochinchinensis, Diospyros confertiflora, Schima wallichi. Korth, Cocos nucifera. L. The results of the inventory become a source of pocket book information on biodiversity material.
PENGARUH MODEL PEMBELAJARAN SEARCH, SOLVE, CREATE, AND SHARE (SSCS) TERHADAP KEMAMPUAN BERPIKIR KRITIS SISWA SMA/MA PADA MATERI SISTEM EKSKRESI
Authors: Ramadhani Nova , Fuadiyah Sa`diatul
Published: September 2023

Critical thinking ability refers to the ability to analyze, evaluate, and solve problems. The purpose of this study was to determine the effect of applying the Search, Solve, Create, And Share (SSCS) learning model on students' critical thinking skills. This type of research is a quasi-experimental research with research methods using Nonequivalent Post Control Group Design. Sampling was carried out by purposive sampling technique, namely class XI IPA 3 and class XI IPA 4 as the control class using the direct learning model. The assessment was carried out on students' critical thinking skills using a written test in the form of multiple choices. From the results of the study, it was found that the critical thinking skills of students in the experimental class had an average of 76.74 with critical criteria, and so on the control class obtained an average of 63.95 with critical criteria. After testing the hypothesis with the t test, the result is that the value of tcount > ttable is 4.7194 > 1.667 which shows that the hypothesis is accepted. Based on the results of the study it was concluded that the application of the Search, Solve, Create, And Share (SSCS) model had a positive effect on the critical thinking skills of students of class XI IPA MAN 2 Padang
PERKEMBANGAN PARIWISATA HALAL DI INDONESIA
Authors: Pranandari Rizka putri , Amaliah Arta , Prihatiningtyas Dian
Published: September 2023

Abstrak:
Indonesia merupakan negara mayoritas muslim, hal ini dapat menjadi potensi pengembangan pariwisata halal. Perkembangan pariwisata halal di Indonesia mengalami pertumbuhan yang positif, terbukti dengan capaian Indonesia di tahun 2019 berada dalam diperingkat ke-2 destinasi wisata ramah muslim kategori OKI. Berbagai landasan hukum juga telah diberlakukan oleh pemerintah. Namun jika kita bandingkan dengan negara Thailand yang juga menduduki peringkat ke-2 dengan kategori negara non OKI, jumlah pengunjung asing di Indonesia bisa dibilang terpaut jauh jika dibandingkan dengan jumlah pengunjung asing di Thailand. Pada tahun 2015 jumlah wisatawan asing di Indonesia hanya sekitar 10,4 juta orang sedangkan jumlah wisatawan mancanegara yang berkunjung ke Thailand mencapai 29,9 juta orang. Pemerintah Thailand dan para stakeholder pariwisata di sana benar-benar serius dalam menggarap sektor pariwisata mereka. Keberhasilan mereka salah      satunya            juga     disebabkan      oleh     strategi jitu       dalam  mengundang            wisatawan mancanegara ke negara mereka. Sejatinya masih banyak juga ditemui di Indonesia restoran self claimed halal yang belum bersertifikat. Jika Indonesia ingin terus mempertahankan dan mengembangkan kualitas dan kuantitas yang ada, maka besar potensi Indonesia untuk menembus peringkat pertama dalam kancah industri halal global. Pentingnya dukungan dari segala aspek akan membuka jalan lebar bagi Indonesia untuk meningkatkan kiprahnya. Perlu juga ditinjau regulasi yang tegas mengenai peredaran alkohol, narkoba, penjualan babi, perjudian, prostitusi, serta barang haram sejenisnya yang tidak sesuai dengan syariah. Kata kunci: Pariwisata Halal, Perkembangan Pariwisata Halal, Industri Halal Global.
Efektivitas Penggunaan Modul Pembelajaran Kimia Berbasis POE Materi Larutan Elektrolit dan Non Elektrolit terhadap Hasil Belajar
Authors: Lela Mutia , Amilda Amilda , Jayanti Etrie
Published: September 2023

This study is motivated by problems related to low student learning outcomes caused by the use of learning resources that are still ineffective and the learning process is still focused on the teacher as the main learning resource. This study aimed to determine the effectiveness of a POE (predict, observe, explain) based chemistry learning module in electrolyte and non-electrolyte solution material on students’ learning outcomes. This was experimental research in the form of pre-experimental with a one-group pretest-posttest design model. The sample in this study was students of class X IPA at one of the public high schools in the Ogan Komering Ilir District, and the sampling in this study used a simple random sampling technique. The data collection technique used in this study was in the form of tests where the instruments were pre-test and post-test questions in the form of multiple choice questions. The effectiveness of the module is seen from the results of data analysis of student learning outcomes using n-gain score and t-test data analysis. Based on the analysis of the n-gain score data, an average score of 0,58 was obtained which was included in the medium category, and the hypothesis test results obtained a sig (ρ) value of 0,000 ˂ 0,05, which means H0 is rejected and H1 is accepted. Based on the analysis results, it was concluded that POE (predict, observe, explain) based chemistry learning module is effective for students’ learning outcomes and can be used as an alternative teaching material.
Hashimoto's encephalopathy presenting with unusual clinical findings in pediatric population: revision of the diagnostic criteria
Authors: GAZETECİ TEKİN Hande , YİLMAZ Sanem , AYAR Murat , EDEM Pınar , TEKGUL Hasan
Published: September 2023

Aim: Hashimoto's encephalopathy is a rare progressive and relapsing disease of presumed

autoimmune origin associated with high titers of thyroid antibodies. Also named steroid-responsive

encephalopathy, the disease can be cured with early treatment. Hashimoto's encephalopathy may

occur with various clinical manifestations, but it often presents with symptoms such as seizures,

confusion, hallucination, sleep abnormalities, and behavioural problems. Patients are mostly euthyroid

or mildly hypothyroid. Hashimoto encephalopathy is a controversial diagnosis for misdiagnosis and

overdiagnosis because of the high prevalence of thyroid antibodies in the population. Therefore, this

diagnosis requires strict criteria that can highly indicate the diagnosis. We aimed to present the

diagnosis and treatment processes from unusual symptoms of patients who are considered to have

Hashimoto's encephalopathy with very strict criteria.

Materials and Methods: Here we present five pediatric patients diagnosed with Hashimoto's

encephalopathy between 2013 and 2023. The clinical signs and symptoms, laboratory findings,

treatment options and response to treatment were obtained from patient records retrospectively.

Results: On admission, patients had striking behavioural changes such as hallucinations, insomnia,

purposeless laughing as well as signs of encephalopathy such as status epilepticus and confusion;

neurological sequelae; history of surgery, and fever. All patients had high levels of thyroid antibodies

and they responded perfectly to steroid treatment in a short period of time.

Conclusion: Hashimoto’s encephalopathy should be considered in all patients presenting with

encephalopathy in the pediatric age group. These patients may have unusual and clinical

manifestations.
İnsan diş pulpası kaynaklı mezenkimal kök hücrelerin meme kanseri kök hücreleri üzerine etkisi
Authors: İNETAŞ YENGİN Gizem , GEYİK Öykü Gönül , BAĞRIYANIK Hüsnü Alper , YÜCE Zeynep , ÖKTEM Gülperi
Published: September 2023

Amaç: Kanser kök hücreleri; kendini yenileyebilen, farklılaşma kapasitesi yüksek ve uzun süreli proliferasyon ile normal dokuya invazyon kabiliyeti olan hücrelerdir. Bu yetenekleriyle geleneksel kanser tedavisine direnç oluşturarak tümör büyümesi ve metastazda rol oynar. Başarılı kanser tedavileri için kanser kök hücre mekanizmalarına yönelik araştırmalar yapmak önem taşımaktadır. Bu çalışmanın amacı, insan diş pulpası kaynaklı mezenkimal kök hücrelerin meme kanseri kök hücreleri üzerine etkisinin hücre canlılığı, hücre döngüsü ve apoptoz yöntemleriyle araştırılmasıdır.

Gereç ve Yöntem: Meme kanseri hücreleri (MCF7) akış sitometrisi ile CD44+/CD24- boyaması yapılarak ayrılmıştır. CD44+/CD24- popülasyonuna meme kanseri kök hücresi denilmiştir. Diş pulpasından izole edilen mezenkimal kök hücreler kültüre edilip karakterizasyonu yapılmıştır. Mezenkimal kök hücre grubu mCitrine, meme kanseri kök hücresi grubu ise mCherry ile plazmit transfeksiyonu yapılarak işaretlenmiştir. Bu hücreler 48 saat boyunca ko-kültüre edilmiş ve sonrasında hücre canlılığı, hücre döngüsü ve apoptoz analizleri yapılmıştır.

Bulgular: Diş pulpası kaynaklı mezenkimal kök hücreler ile ko-kültüre edilen meme kanseri kök hücrelerinin kontrol grubuna göre hücre canlılığı, hücre döngüsü ve apoptoz değerlerinde zamana bağlı olarak istatistiksel anlamlı değişiklikler görülmüştür. Ko-kültüre grubu kontrole göre kıyaslandığında zamana bağlı olarak G0/G1 evresinde artış gözlenmiştir. Ko-kültüre edilen hücrelerin floresan mikroskop ile yapılan incelemesinde sarı floresan işaretli hibrit hücreler gözlenmiştir ve immüno-floresan Ki67 boyamasında hücre sayısında azalma gözlenmiştir.

Sonuç: Ko-kültür sonrası diş pulpası kaynaklı mezenkimal kök hücrelerin meme kanser kök hücreleri üzerinde hücre proliferasyonunu inhibe edici etkileri olduğu ve apoptozu teşvik ettiği gözlenmiştir. Sonuç olarak, meme kanser kök hücreleri üzerinde diş pulpası kaynaklı mezenkimal kök hücrelerin tedaviye yönelik bir etkisi olabilir.
Evolution of a Stratified Turbulent Cloud under Rotation
Authors: Li Tianyi , Wan Minping , Chen Shiyi
Published: September 2023

Localized turbulence is common in geophysical flows, where the roles of rotation and stratification are paramount. In this study, we investigate the evolution of a stratified turbulent cloud under rotation. Recognizing that a turbulent cloud is composed of vortices of varying scales and shapes, we start our investigation with a single eddy. Compared to an eddy under pure rotation, the stratified eddy shows the physical manifestation of a known potential vorticity mode, appearing as a static stable vortex. In addition, the expected shift from inertial waves to inertial-gravity waves is observed. In our numerical simulations of the turbulent cloud, carried out at a constant Rossby number over a range of Froude numbers, stratification causes columnar structures to deviate from vertical alignment. This deviation increases with increasing stratification, slowing the expansion rate of the cloud. The observed characteristics of these columnar structures are consistent with the predictions of linear theory, particularly in their tilt angles and vertical growth rates, suggesting a significant influence of inertial-gravity waves. Using Lagrangian particle tracking, we have identified regions where wave activity dominates over turbulence. In scenarios of milder stratification, these inertial-gravity waves are responsible for a significant energy transfer away from the turbulent cloud, a phenomenon that attenuates with increasing stratification.
Wild Oats Offer New Possibilities for Forage Because of the Higher Nutrition Content and Feed Value
Authors: Zhang Jieyu , Li Xaiolong , Wang Junzhen , Li Yang , Yang Qiaohui , Xiang Dabing , Wan Yan , Nevo Eviatar , Yan Jun , Yu Fan , Zou Liang
Published: September 2023

To explore the forage quality of wild oat populations under different growth environments, the basic nutrient composition and forage quality of five wild oat populations in Israel were compared. Ash, crude protein, and soluble sugar content of oats were significantly (P<0.05) related to some forage quality and possible environment of population origin. Among them, the environmental factors of origin had significant effects on the indicators of ash, crude protein, and soluble sugars of oat straw, but less on the contents of crude fat, total phosphorus, and total potassium. Meanwhile, the annual rainfall and the number of days of rainfall in the country of origin greatly influenced the cellulose content. Finally, we investigated the similarity of feeding values of different populations using PCA analysis. The results showed that, in conclusion, the higher variability of wild oat populations may be a new possibility brought by feeding oats.
Mosaic Neuroendocrine-/Adenocarcinoma of the Prostate: Clinical and Histological Description
Authors: Almási Kálmán , Kránitz Noémi , Kullmann Tamás
Published: September 2023

Background: Mosaic cancers are composed of two or several genetically different cell populations. Mosaicism has been considered to be rare among malignancies, with the exception of the germ cell tumours. Although it has been described that neuroendocrine foci may be present within an adenocarcinoma of the prostate, this was ment for advanced stage disease and the clinical relevance of the histological finding has not been clarified. Patients and methods: We recently published the analysis of a small cohort of patients who had neuroendocrine cancer of the prostate. Contrarily to the general assumption of a rare disease with poor prognosis, the incidence was found to be 2%, being 50 fold higher than the earlier data. During the follow-up the overall survival of some metastatic patients reached several years. The particularity of patients with favourable outcome was the parallel elevation of PSA and NSE. They received anticancer treatments in an alternating way directed according to the tumour marker that was in rise. The aim of this paper is to show the pathological background of our clinical observations. Results: Histological images of de novo mosaic prostate cancers are shown. A model explaining the development of mosaic prostate cancers is presented. The hypothesis of mosaicism within adenocarcinomas is formulated in addition. Conclusion: Mosaic neuroendocrine-/adenocarcinoma of the prostate is underestimated regarding its incidence as well as its prognosis.
The Edge of Chaos Is That Where Consciousness Manifests Itself through Intermittent Dynamics
Authors: Sbitnev Valeriy I
Published: September 2023

Consciousness is a special type of interaction between subjects exchanging by lingua quanta (phonemes). A set of lingua quanta composes a thesaurus placed on the edge of chaos. Its library is a memory, modification of which is due to tuning of memristive neural elements scattered in the brain volume. The memristive neural model takes into consideration two types of neurons - excitatory and inhibitory and the current leakage, all at the body temperature, T = 309 K. At such temperatures only heavy ions like hydrogen ions - protons can pass robustly through the water medium of the brain. The robust ion transport is proton water wires supported by the Grotthuss mechanism. Final aims of the ions are the gap junctions (electric synapses) linking nearest neurons. Following these observations, a model of excitable nervous tissue is constructed. Namely, a difference mapping on the basis of sigmoid curves can reproduce chaotic modes of neural activity proved by positive values of the Lyapunov exponent. The edge of chaos is placed near the bifurcation boundary dividing the chaos and the periodic convulsive activity typical at the epileptic discharges. In this region the self-sustained spiral waves occur. An intermittent activity of the competing excitatory and inhibitory neurons is observed on the edge of chaos. The intermittent electrical activity of neural tissues is demonstrated by records both from different literature issues and records made by the author together with DR. A. Dudkin on slices of CA1 field of the hippocampus.
Flux Growth and Characterization of Bulk InVO4 Crystals
Authors: Voloshyna Olesia , Gorbunov Mikhail V. , Mikhailova Daria , Maljuk Andrey , Seiro Silvia , Büchner Bernd
Published: September 2023

The flux growth of InVO4 bulk single crystals has been explored for the first time. The reported eutectic composition at a ratio of V2O5:InVO4 = 1:1 could not be used as a self-flux, since no sign of melting was observed up to 1100 °C. Crystals of InVO4 of typical size 0.5×1×7 mm3 were obtained using copper pyrovanadate (Cu2V2O7) as a flux, using Pt crucibles. XRD confirmed the orthorhombic Cmcm structure. Rests of flux material were observed on the sample surface, with occasional traces of Pt indicating some level of reaction with the crucible. X-ray absorption spectroscopy showed that oxidation states of indium and vanadium ions are +3 and +5, respectively. The size and high quality of the obtained InVO4 crystals makes them excellent candidates for the further study of their physical properties.
Family control, leverage, and quality of earnings: a study on manufacturing companies in Indonesia
Authors:   Sebelas Maret University, Murni Sri , Rahmawati  ,   Sebelas Maret University, Widagdo Ari Kuncara ,   Sebelas Maret University, Sudaryono Eko Arief ,   Sebelas Maret University
Published: September 2023

Earnings quality can be influenced by family control through entrenchment effect and alignment effect. This study examines family control in improving earnings quality and leverage in moderating family control on earnings quality - the quantitative descriptive research method used as a research method. Manufacturing enterprises registered on the Indonesia Stock Exchange for 2017 and 2018 make up the research population. The data in this study are unbalanced. Secondary data was gathered from annual reports, prospectus reports, the Indonesian Capital Market Directory, and other sources for this study. The research topic is determined by applying the definition of a family business. The variables in this study include abnormal cash flows, abnormal production costs and, abnormal discretionary costs. They were testing the hypothesis using regression analysis (Ordinary Least Square/OLS). The results showed that family control did not affect real earnings management. This shows that strong family control does not affect earnings quality. The leverage variable only moderates the effect of family control on abnormal cash flow from operations (REMCFO).
Organization of internal quality and safety control of medical activities in the conditions of a clinic providing medical care on the profile «ophthalmology».
Authors:   State Autonomous Health Institution «The Republican Clinical Ophthalmic Hospital of Ministry of Health of the Republic of Tatarstan named after Professor E. V. Adamyuk, Zigangareeva G. G. ,   Kazan State Medical Academy – Branch Campus of the FSBEIFPE RMACPE MOH Russia, Koroleva O. I. ,   State Autonomous Health Institution «The Republican Clinical Ophthalmic Hospital of Ministry of Health of the Republic of Tatarstan named after Professor E. V. Adamyuk, Khusainova D. K. ,   State Autonomous Health Institution «The Republican Clinical Ophthalmic Hospital of Ministry of Health of the Republic of Tatarstan named after Professor E. V. Adamyuk
Published: September 2023

R e l e v a n c e . Currently, the issues of ensuring the quality and safety of medical activities are one of the priority areas in healthcare management. The legislation of the Russian Federation has determined the organization and conduct of internal quality control and safety of medical activities as a licensing requirement. Identified inconsistencies/violations in the provision of medical care are one of the elements of risk management and should be used to improve the efficiency of medical organizations. T h e p u r p o s e of the study is to develop management practices to improve the quality and safety of medical activities using the results of external audits in the field of compulsory health insurance. M a t e r i a l s a n d m e t h o d s . The analysis of modern requirements of normative legal acts of quality control and safety of medical activity has been carried out, the main tools used in conducting external audits in the system of compulsory medical insurance have been systematized. R e s u l t s . The modern architecture of quality control and safety of medical activities includes 5 levels of control. The tools for monitoring the quality of medical care for identifying violations, applying financial sanctions to a medical organization are described. In order to improve the quality and safety of medical activities, the development of corrective measures and various management practices is recommended. C o n c l u s i o n s . The results of external audits are an important element of the modern model of quality management and safety of medical activities, which should be integrated into the work of a medical organization of any profile for use in a system of continuous quality improvement.
Opinion of pediatric otorhinolaryngologists on the main problems in the organization of medical care and priority areas of activity of the professional medical community.
Authors:   N. A. Semashko National Research Institute of Public Health, Oleinik A. V. , Mingazova E. N. ,   N. A. Semashko National Research Institute of Public Health,   Kazan State Medical University
Published: September 2023

A medical and sociological study was carried out in order to determine the opinion of specialists on current problems in the organization of children’s otorhinolaryngological care and on the priority areas of activity of the professional medical community. Five main medical and organizational problems in the organization of children’s otolaryngological care are identified: maintaining and developing human resources, stimulating the work of medical workers; improvement of resource support for assistance, stimulation of investments in the development of the material, technical and technological base; increasing the availability of qualified assistance; management optimization; improvement of methodological support and introduction of modern technologies for rendering assistance. Pediatric otorhinolaryngologists consider the main activities of the professional community to be: representing the legitimate interests of the Association members, promoting the protection of their professional and social rights; assistance and participation in advanced training and professional retraining of specialists; professional consolidation, strengthening and development of relations between specialists; meeting the needs of specialists in obtaining knowledge about the latest achievements, advanced domestic and foreign experience.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и субвариантов Omicron, находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 9 по 15 сентября 2023 г.
Authors: Зимирова Анастасия , Краснов Ярослав , Чумачкова Елена , Дмитриева Людмила , Осина Наталья , Иванова Александра , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: September 2023

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих интерес (VOI) и субвариантов Omicron, находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 09.09.2023 г. по 15.09.2023 г.
Data Analytics in Reservoir Engineering
Authors: Sankaran Sathish , Matringe Sebastien , Sidahmed Mohamed , Saputelli Luigi , Wen Xian-Huan , Popa Andrei , Dursun Serkan
Published: September 2023

Data analytics is fundamentally transforming industries. In recent years, there is a growing application of digital technologies in oil and gas exploration and production. At the same time, oil and gas operations are becoming increasingly complicated with modern facility infrastructures, complex reservoirs, increased regulatory requirements, changing workforce demographics, the fast pace of unconventional-field development and ultimately with much more competition. Data Analytics in Reservoir Engineering focuses on how best to use data analytics to transform the decision-making process in characterizing reservoir parameters, model reservoir behavior and forecast performance.
Molar-scale formate production via enzymatic hydration of industrial off-gases
Authors: Kim Yong Hwan , Lee Jinhee , Kim Suk Min , Jeon Byoung Wook , Hwang Ho Won , Poloniataki Eleni G. , Lee Sanghyung , Ra Ho Won , Na Jeong-Geol , Lee Jinwon
Published: September 2023

Decarbonizing the steel industry, a major CO2 emitter, is crucial for achieving carbon neutrality1,2. Escaping the grip of CO combustion methods, a key contributor to CO2 discharge is a seemingly simple yet formidable challenge on the path to industrial-wide net-zero carbon emissions1,3–5. Here we suggest the enzymatic CO hydration (enCOH), inspired by the biological Wood‒Ljungdahl pathway, enabling efficient CO2 fixation. By employing the highly efficient, inhibitor-robust CO dehydrogenase (ChCODH2) and formate dehydrogenase (MeFDH1), we achieved spontaneous enCOH, to convert industrial off-gases into formate with 100% selectivity. This process operates seamlessly under mild conditions (room temperature, neutral pH), regardless of varying CO/CO2 ratios. Notably, the direct utilization of flue gas without pretreatment yielded various formate salts, including ammonium formate, at concentrations nearing two molars. Operating the 10 L-scale immobilized enzyme reactor at the steel mill resulted in the production of high-purity formate powder after facile purification, thus demonstrating the potential for decarbonizing the steel industry.
Performance of patterned single-layer diamond grinding wheel in grinding of Al-SiCP composites with large infeed
Authors: Nanda Trilochan Prasad , Ghosh Amitava
Published: September 2023

The grinding process has been evolving, in recent years, from a mere surface finishing operation to a high stock removal process. The current research work is focused on the development of new-generation single-layer diamond wheels which can accomplish the demanding high material removal rate (MRR) requirements with longer tool life without any wheel dressing. With the use of a novel coordinate-controlled grit patterning technique, single-layer brazed diamond wheels were fabricated with uniform and precise distribution of the abrasive particles, which enables the wheels to accommodate higher chip load without loading and to simultaneously possess stronger joint strength. The indigenously developed grinding wheel was tested under aggressive grinding conditions to machine Al-SiCP composite blocks up to a depth of 2.5 mm under flood cooling environment. Grinding forces, real-time spindle power consumption, and post-grinding wheel morphology were investigated during the deep grinding experiments to evaluate the suitability of such wheels in stringent grinding conditions.
Experiments were conducted up to a maximum uncut chip thickness of 5.4 μm and maximum specific MRR of 20.83 mm2/s. Specific grinding energy, as low as 10.8 J/mm3, was obtained at the grinding condition with an aggressiveness number of 19.04. At the end, the in-house developed patterned diamond grinding wheel could successfully grind the soft, sticky and abrasive Al-SiCP composites without any trace of wheel loading or significant grit failures.
Prenatal exposure to bisphenols and visual impairment in preschool children : a prospective birth cohort study in China
Authors: Li Jinxiu , Mo Caimei , Liang Jun , Luo Xingxi , Tang Peng , Lei Lei , Wang Lijun , Huang Dongping , Qiu Xiaoqiang , Zeng Xiaoyun , Liu Shun
Published: September 2023

Evidence from animal experiments suggests that exposure to bisphenols during early life may lead to impaired eye development and visual functions. However, population-based study on the association remains very limited. To investigate the relationships between prenatal bisphenols exposure and visual impairment in preschool children. A total of 744 mother-infant pairs were extracted from the Guangxi Zhuang Birth Cohort in China. Maternal serum bisphenol A (BPA) and its alternatives were measured by using ultra-high liquid performance chromatography-tandem mass spectrometer. Visual acuity in preschool children were followed up in the local maternal and child health information management system. The associations of prenatal exposure to bisphenols (BPs) with visual acuity were analyzed by multivariate linear regression models. Logistic regression model, Bayesian Kernel machine regression (BKMR), and quantile g-computation (Qgcomp) models were applied to examine the single and mixture effects of prenatal exposure to the five BPs on risk of visual impairment (VI).In logistic regression models, the moderate-level BPA-exposed group (OR = 0.474, 95%CI: 0.211, 1.065) and high-level TBBPA-exposed group (OR = 0.451, 95%CI: 0.184, 1.109) had a lower risk of VI than the low-level exposed group, both approaching a level of significance (P = 0.071 and P = 0.083, respectively). When stratified analysis by child sex, the significant associations of moderate-level BPA exposure and VI risk were only found among boys (adjusted OR = 0.230, 95%CI: 0.061, 0.873, P = 0.031). And a suggestive negative association of high-level TBBPA exposure and VI risk was only found among girls (adjusted OR = 0.330, 95%CI: 0.091, 1.193, P = 0.091). Further analysis by using BKMR and g-computation models showed that mixed effects of the five BPs were also associated with decreased risk of VI, with effects-driven primarily by BPA and TBBPA for boys and girls, respectively. Findings from this study do not support the hypothesis that prenatal BPs exposure is associated with increased risk of VI. Further epidemiological studies remain warranted when confirming their associations.
BCR-ABL1 Transcript and Philadelphia Negative T-Cell Lymphoblastic Lymphoma: A Case Report and Literature Review
Authors: Li Yang , Zhang Bin , Li Qiuling , Li Shouyun , He Jinsong , Li Jiesi , Wang Qi , Hu Bo , Wang Huijun , Sun Qi , Li Chengwen , Tong Chunfan , Zhai Weitao , Mi Yingchang , Yan Zhangsong
Published: September 2023

Background: Lymphoblastic lymphoma (LBL) is a malignant tumor, with most cases derived from T cells and less than 20% arising from B cells. T-LBL originates from immature T cell precursors or lymphoblasts. It is mainly found in the lymph nodes, and the bone marrow is involved in less than 25%. The Philadelphia chromosome (Ph) is the first cytogenetic abnormality related to chronic myeloid leukemia (CML), a human tumor. Together with CML, a derivative rearrangement of the chromosomes between 9 and 22, containing the BCR-ABL1 fusion gene, can be detected in acute lymphoblastic leukemia (ALL). However, this is rarely reported in T-cell ALL/LBL cases. Herein, we report a case of T-LBL with a normal chromosomal karyotype but with a BCR-ABL1 fusion transcript.
Case presentation: A 72-year-old male with no remarkable medical history was admitted with cervical lymph node enlargement of more than 1 month. Physical examination revealed several enlarged bilateral lymph nodes in the neck and supraclavicular fossae. The patient underwent neck lymphadenectomy, with two lymph nodes completely resected. Pathological assessment and flow cytometry immunophenotypic analysis were suggestive of infiltration by lymphoma cells. Two weeks following induction therapy (mini-hyper-CVD [C:CTX, cyclophosphamide, V:VCR, vincristine, D:DXM, dexamethasone] combined with venetoclax), flow cytometry immunophenotypic analysis of bone marrow cells revealed measurable residual disease, and real-time polymerase chain reaction (RT-PCR) revealed that BCR-ABL1 rearrangement decreased from 35.13% to 2.71%. The second regimen consisted of methotrexate + cytarabine combined with tyrosine kinase inhibitors. The patient then received targeted drugs combined with chemotherapeutic drugs as maintenance therapy and was in complete remission for 16 months following diagnosis. Positron emission tomography revealed a complete metabolic response after therapy for 4 and 15 months, and RT-PCR revealed that BCR-ABL1 rearrangement was 0.04% after 15 months of therapy.
Conclusions: For older adults with lymphoblastic leukemia/lymphoma, mini-hyper-CVD combined with other novel drugs provides a promising treatment approach; however, the subtypes of the disease, patient age, and comorbidity profile are all important variables to consider. Further, fluorescence in situ hybridization and RT-PCR testing performed on bone marrow and lymph node specimens for BCR-ABL1 rearrangements as part of routine diagnostic tests are recommended.
Coccidioidomycosis Emergence in South America: Exploring Northeastern Brazil's Epidemiological, Clinical, and Genomic Landscape
Authors: Teixeira Marcus , Eulálio Kelsen , Kollath Daniel , Martins Liline , Filho Antônio , Cavalcanti Maria , Moreira Lucas , Tenório Bernardo , Alves Lucas , Yamauchi Danielle , Benard Gil , III George Thompson , Nacher Mathieu , Stajich Jason , Bagagli Eduardo , Felipe Maria , Barker Bridget , Trilles Luciana
Published: September 2023

Coccidioidomycosis is an invasive mycosis included in WHO’s priority list. It is endemic and notifiable in the United States but neglected in Central and South America. We used a multi-institutional approach to assess whether disease characteristics, genetic variation in the pathogen or environmental factors affects the epidemiology of coccidioidomycosis and disease outcomes throughout the American continent. We identified 292 patients with coccidioidomycosis between 1978 and 2021 in the Piauí and Maranhão states of Brazil; the largest cases series reported outside the US/Mexico epidemic range. The male-to-female ratio was 57.4:1 and the main risk factor was armadillo hunting (91.1%) 4 to 30 days before symptom onset. Forty-two outbreaks involving two to six patients were observed. Most patients (92.8%) presented typical acute pulmonary disease, followed by disseminated (3.4%), chronic pulmonary (2.4%) and regressive pulmonary (1.4%). The most frequent clinical symptoms were cough (93%), fever (90%) and chest pain (77%). Mortality was observed in 8% of the patients. In 2004, and between 2015 and 2017, we observed a spike in coccidioidomycosis in Brazil, particularly in the state of Piauí. Unlike other main hotspots, the soil is acidic in this region and precipitation (p = 0.015) and precipitation one-year prior (p = 0.001) were predictors of higher coccidioidomycosis rates. The Brazilian strains are genotypically divergent from other described C. posadasii within the Texas/Mexico/South America clade. Coccidioidomycosis in Northeastern Brazil has a specific infection profile and armadillo hunters are at higher risk. Low pluviosity and extensive drought appear key to increasing the number of cases in Brazil. A unique C. posadasii lineage exists in Brazil; therefore, environmental, virulence, and/or pathogenesis traits may differ from other Coccidioides genotypes.
Cathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
Authors: Cohen Ehud , Siddiqui Atif , Merquiol Emmanuelle , Boocholez Hana , Yan Yong-Hong , Dong Meng-Qiu , Blum Galia
Published: September 2023

While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity of the AD-causing Amyloid β (Aβ), is controversial. Using an activity-based probe, aging-altering interventions and the nematode C. elegans we discovered that the CTSB CPR-6 promotes Aβ proteotoxicity but mitigates the toxicity of polyQ stretches. While the knockdown of cpr-6 does not affect lifespan, it alleviates Aβ toxicity by reducing the expression of swsn-3 and elevating the level of the protein SMK-1, both involved in the regulation of aging. These observations unveil a novel mechanism by which CTSB aggravates Aβ–mediated toxicity, indicate that it plays opposing roles in the face of distinct proteotoxic insults and highlight the importance of tailoring specific remedies for distinct neurodegenerative disorders.
Prevalence of Alcohol Consumption by Medical Students in Northeast Brazil
Authors: Oliveira Rivando Rodrigues Sousa , Feder David , Souza Luiz Vinicius Alcantara , Chehter Ethel Zimberg
Published: September 2023

Objective
This research aims to verify the prevalence of alcohol consumption by medical students from the first to the twelfth semester at the Federal University of Paraíba (UFPB) - Campus I.
Methods
This is an analytical, quantitative, and transversal research. A total of 293 medical students participated in the study, divided into two groups: Group 1 with 155 students, from the 1st to the 6th semester, and Group 2 with 138 students, from the 7th to the 12th semester. Two questionnaires were used: a sociodemographic questionnaire with questions about alcohol preference, family alcohol consumption, and psychoactive substance use. The second questionnaire refers to the Alcohol Use Problems Identification Test (AUDIT).
Results
The prevalence of alcohol consumption was higher for the second group, with 63.23% and 77.54%, respectively. It was noticed that in the last years of the course there is a more favorable context to continue using alcohol, considering the stress experienced and a greater overload in the last semesters of the undergraduation. However, based on AUDIT, there was a predominance of low risk for both groups, with 90.97% and 86.23%, respectively.
Conclusions
It was concluded that, although there is a predominance of low risk in the consumption scale, there is a concern that permeates the literature of the area and practice regarding the importance of discussing the topic of alcohol consumption with medical students, since they need to understand the multiple risks present in alcohol abuse as students and future health professionals.
Increased CO2 Fixation Enables High Carbon-Yield Production of the Acrylic Acid Precursor 3-Hydroxypropionic Acid in Yeast
Authors: Liu Zihe , Qin Ning , Li Lingyun , Wan Xiaozhen , Ji Xu , Chen Yu , Li Chaokun , Liu Ping , Zhang Yijie , Yang Weijie , Jang Junfeng , Xia Jianye , Shi Shuobo , Tan Tianwei , Nielsen Jens , Chen Yun
Published: September 2023

CO2 fixation plays a key role to make biobased production cost competitive. Here, we used 3-hydroxypropionic acid (3-HP) to showcase how CO2 fixation enabled approaching theoretical-yield production. Using genome-scale metabolic models to calculate the production envelope, we demonstrated that the provision of bicarbonate, formed from CO2, sealed previous attempts for high yield production of 3-HP. We thus developed multiple strategies for bicarbonate uptake, including the identification of Sul1 as a bicarbonate transporter, domain swapping and engineering of malonyl-CoA reductase, identification of Esbp6 as a 3-HP exporter, and deletion of Uga1 to prevent 3-HP degradation. The combined rational engineering increased 3-HP production from 0.15 g/L to 11.25 g/L in shake-flask using 20 g/L glucose, approaching the maximum theoretical yield with concurrent biomass formation. The engineered yeast forms the basis for commercialization of bio-acrylic acid, while our CO2 fixation strategies pave the way for CO2 being used as the sole carbon source.