bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of iRGD-Ligand Modified Arginine-Histidine-Rich Peptides for Nucleic Acid Therapeutics Delivery to αvβ3 Integrin-Expressing Cancer Cells
Authors: Egorova Anna , Selutin Alexander , Maretina Marianna , Selkov Sergei , Baranov Vladislav , Kiselev Anton
Published: October 2020

Efficient and specific delivery of nucleic acid (NA) therapeutics to tumor cells is extremely important for cancer gene therapy. Various therapeutic strategies include delivery of DNA-therapeutics such as immunostimulatory or suicide genes and delivery of siRNA-therapeutics able to silence expression of cancer-related genes. Peptides are a promising class of non-viral vehicles which are biodegradable and can efficiently condense, protect and specifically deliver NA to the cells. Here we designed arginine-histidine-rich peptide carriers consisting of an iRGD ligand to target αvβ3 integrins and studied them as vehicles for DNA and siRNA delivery to cancer cells. Combination of iRGD-modified and unmodified arginine–histidine-rich peptides during NA complexation resulted in carriers with different ligand contents. The NA-binding and protecting properties in vitro transfection efficiency and cytotoxicity of the DNA- and siRNA-polyplexes were studied and the most efficient carrier RGD1 was determined. The ability of the peptides to mediate specific intracellular uptake was confirmed inhuman cervical carcinoma (HeLa), human kidney (293T) and human pancreatic (PANC-1) cell lines with different αvβ3 integrins surface expression. By means of RGD1 carrier, efficient delivery of the herpes simplex virus (HSV-1) thymidine kinase gene to PANC-1 cells was demonstrated. Subsequent ganciclovir treatment led to a reduction of PANC-1 cells’ viability by up to 54%. Efficient RNAi-mediated down-regulation of GFP and VEGFA gene expression was achieved in MDA-MB-231-GFP+ breast cancer and EA.hy926 endothelial cells, respectively, by means of RGD1/siRNA polyplexes. Here we demonstrated that the peptide carrier RGD1 can be considered as promising candidate for development of NA therapeutics delivery systems useful in cancer gene therapy.
Characterization of Novel Dipeptidyl Peptidase-IV Inhibitory Peptides from Soft-Shelled Turtle Yolk Hydrolysate Using Orthogonal Bioassay-Guided Fractionations Coupled with In Vitro and In Silico Study
Authors: Nong Nhung Thi Phuong , Chen Yu-Kuo , Shih Wen-Ling , Hsu Jue-Liang
Published: October 2020

Five novel peptides (LPLF, WLQL, LPSW, VPGLAL, and LVGLPL) bearing dipeptidyl peptidase IV (DPP-IV) inhibitory activities were identified from the gastrointestinal enzymatic hydrolysate of soft-shelled turtle yolk (SSTY) proteins. Peptides were isolated separately using reversed-phase (RP) chromatography in parallel with off-line strong cation exchange (SCX) chromatography followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to determine sequences. Among these peptides, LPSW showed the highest DPP-IV inhibitory activity with an IC50 value of 269.7 ± 15.91 µM. The results of the pre-incubation experiment and the kinetic study of these peptides indicated that WLQL is a true inhibitor and its inhibition toward DPP-IV is of an uncompetitive model, while LPLF, LPSW, and VPGLAL are real-substrates and competitive inhibitors against DPP-IV. The DPP-IV inhibitory peptides derived from SSTY hydrolysate in study are promising in the management of hyperglycemia in Type 2 diabetes.
Norwegian Christian Leaders: The Term ‘Christian Values’ is Divisive and Useless
Authors: Haugen Hans Morten
Published: October 2020

Church leaders and politicians in several countries make frequent references to Christian values as part of a rhetoric of dividing between wanted and unwanted view and practices. Hence, even more than a source for division between adherents of different faiths, religion divides adherents of the same faith when identifying the core of religion. The article presents findings from a survey and focus group interviews with five groups of Norwegian Christian leaders: church leaders, bishops and deans from the Church of Norway, as well as leaders in mission organization and diaconal foundations. The informants are generally very hospitable towards immigrants, not particularly skeptical of Islam, and highly skeptical of politicians applying the term ‘Christian values’ for protectionist purposes. While distancing themselves from the term ‘Christian values’, informants have a clear understanding of what these values encompass. These attitudes mirror the major attitudes among the so-called church-going Norwegians in the Pew report, “Being Christian in Western Europe”, having higher appreciation of both Islam and immigration than the other groups of informants. The article proceeds by explaining and contextualizing, including how the churches have promoted conviviality in diverse societies and whether the leaders are willing to act when Christianity is applied to legitimize nativism.
Geopolitics of Papal Traveling: (Re)Constructing a Catholic Landscape in Europe
Authors: Barbato Mariano P.
Published: October 2020

For the popes, traveling has developed into a key instrument for mobilizing masses, spreading messages, and shaping public Catholic identities. Traveling ranks high within the papal efforts to (re)construct a Catholic landscape in Europe. Thus, comparing the European travel schedules of Pope Benedict XVI and Pope Francis in the context of their global journeys can help to understand their different conceptualizations of Europe. While both popes share the focus on Marian shrines, mass events, Parliamentary addresses, and interfaith encounters that has been established by their predecessors, their geopolitical strategies differ completely. Benedict XVI placed visits to major European nations and regions at the center of his travel schedule and tried to strengthen a historical Catholic identity. Francis shifted the focus of papal traveling to other continents and approached Europe from the periphery. He has visited the European institutions in Strasbourg and tried to shape an interreligious public identity of Europe.
Is the Board of Directors’ Religion Related to Tax Avoidance? Empirical Evidence in South Korea
Authors: Cho Hyeong Tae , Yoon Sung Man
Published: October 2020

This study investigates the effect of directors’ religious diversity on tax avoidance of firms. The board of directors plays an important role in supervising the management of the corporation. As such, the religious diversity of the board may affect corporate decisions and their implementation by the management. In this regard, this study analyzes the effect of the religious diversity of the directors on the level of tax avoidance. Results are presented as follows. First, the level of tax avoidance tends to be higher when the level of religious diversity among the board members is high. Second, tax avoidance level may be different depending on a CEO’s religion, holding that the religions of board members are diverse. Third, the tax avoidance activity of a corporation is likely to be discouraged if the religions of board members are converged into a single religion. Overall, the results of this study provide an implication that religious factors influence the level of the firm’s tax avoidance.
Impact of Mild Hypohydration on 100 m Front Crawl Performance and Starting Block Peak Force Production in Competitive University-Level Swimmers
Authors: Abed Mohamed El Fethi , Deshayes Thomas A. , Claveau Pascale , Jeker David , Thénault François , Goulet Eric D.B.
Published: October 2020

Unstructured, ad libitum drinking may predispose some athletes to start exercise already slightly hypohydrated (decreased body water). The impact of pre-exercise mild hypohydration on subsequent swimming performance is still unknown. Hence, the goal of this study was to examine its effect on peak force production on the starting block and 100 m front crawl swimming performance in competitive university-level swimmers. At least one hour after having been passively exposed to heat where a body mass loss of 1.5% was induced or euhydration (normal body water) maintained, nine participants (age: 22 ± 2 years) underwent an assessment of their peak force production on the starting block and 100 m front crawl performance. One hour following hypohydration, rectal temperature had returned to baseline in each condition. Urine osmolality and specific gravity were higher (p < 0.05) with hypohydration than euhydration (995 ± 65 vs. 428 ± 345 mOsmol/kg; 1.027 ± 0.003 vs. 1.016 ± 0.007 g/mL) prior to exercise testing, as was perceived thirst. Swimming performance (p = 0.86) and peak force production (p = 0.72) on the starting block did not differ between the hypohydration and euhydrated condition (63.00 ± 4.26 vs. 63.09 ± 4.52 s; 1322 ± 236 vs. 1315 ± 230 N). The current results indicate that mild hypohydration, which may occur with ad libitum drinking, does not impede peak force production on the starting block and 100 m front crawl performance in university-level competitive swimmers. Planned drinking is not required prior to such an event.
Singularity Theorems in the Effective Field Theory for Quantum Gravity at Second Order in Curvature
Authors: Kuipers Folkert , Calmet Xavier
Published: October 2020

In this paper, we discuss singularity theorems in quantum gravity using effective field theory methods. To second order in curvature, the effective field theory contains two new degrees of freedom which have important implications for the derivation of these theorems: a massive spin-2 field and a massive spin-0 field. Using an explicit mapping of this theory from the Jordan frame to the Einstein frame, we show that the massive spin-2 field violates the null energy condition, while the massive spin-0 field satisfies the null energy condition, but may violate the strong energy condition. Due to this violation, classical singularity theorems are no longer applicable, indicating that singularities can be avoided, if the leading quantum corrections are taken into account.
Superimposition of Viral Protein Structures: A Means to Decipher the Phylogenies of Viruses
Authors: Ravantti Janne J. , Martinez-Castillo Ane , Abrescia Nicola G.A.
Published: October 2020

Superimposition of protein structures is key in unravelling structural homology across proteins whose sequence similarity is lost. Structural comparison provides insights into protein function and evolution. Here, we review some of the original findings and thoughts that have led to the current established structure-based phylogeny of viruses: starting from the original observation that the major capsid proteins of plant and animal viruses possess similar folds, to the idea that each virus has an innate “self”. This latter idea fueled the conceptualization of the PRD1-adenovirus lineage whose members possess a major capsid protein (innate “self”) with a double jelly roll fold. Based on this approach, long-range viral evolutionary relationships can be detected allowing the virosphere to be classified in four structure-based lineages. However, this process is not without its challenges or limitations. As an example of these hurdles, we finally touch on the difficulty of establishing structural “self” traits for enveloped viruses showcasing the coronaviruses but also the power of structure-based analysis in the understanding of emerging viruses
Advances in Honey Bee Virus Research
Authors: Chejanovsky Nor
Published: October 2020

The sudden collapse of honey bee colonies in California in 2005 and alarming reports about significant colony losses in the U [...]
Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9
Authors: Olson Alex , Basukala Binita , Lee Seunghee , Gagne Matthew , Wong Wilson W. , Henderson Andrew J.
Published: October 2020

The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production with latency-reversing agents followed by the killing of cells actively producing the virus by immune clearance. However, this approach does not induce all intact proviruses, leaving a residual reservoir. CRISPR/Cas9 has been utilized to excise integrated Human Immunodeficiency Virus (HIV) DNA from infected cells in an RNA-guided, sequence-specific manner. Here, we seek to epigenetically silence the proviral DNA by introducing nuclease-deficient disabled Cas9 (dCas9) coupled with a transcriptional repressor domain derived from Kruppel-associated box (KRAB). We show that specific guide RNAs (gRNAs) and dCas9-KRAB repress HIV-1 transcription and reactivation of latent HIV-1 provirus. This repression is correlated with chromatin changes, including decreased H3 histone acetylation and increased histone H3 lysine 9 trimethylation, histone marks that are associated with transcriptional repression. dCas9-KRAB-mediated inhibition of HIV-1 transcription suggests that CRISPR can be engineered as a tool for block-and-lock strategies.
Therapeutic Vaccines and Cancer Immunotherapy
Authors: Bhatt Darshak , Daemen Toos
Published: October 2020

Cancer immunotherapy and immunization are the next steps towards safe and effective cancer treatment [...]
A Recombinant Zika Virus Envelope Protein with Mutations in the Conserved Fusion Loop Leads to Reduced Antibody Cross-Reactivity upon Vaccination
Authors: Berneck Beatrice Sarah , Rockstroh Alexandra , Fertey Jasmin , Grunwald Thomas , Ulbert Sebastian
Published: October 2020

Zika virus (ZIKV) is a zoonotic, human pathogenic, and mosquito-borne flavivirus. Its distribution is rapidly growing worldwide. Several attempts to develop vaccines for ZIKV are currently ongoing. Central to most vaccination approaches against flavivirus infections is the envelope (E) protein, which is the major target of neutralizing antibodies. Insect-cell derived, recombinantly expressed variants of E from the flaviviruses West Nile and Dengue virus have entered clinical trials in humans. Also for ZIKV, these antigens are promising vaccine candidates. Due to the structural similarity of flaviviruses, cross-reactive antibodies are induced by flavivirus antigens and have been linked to the phenomenon of antibody-dependent enhancement of infection (ADE). Especially the highly conserved fusion loop domain (FL) in the E protein is a target of such cross-reactive antibodies. In areas where different flaviviruses co-circulate and heterologous infections cannot be ruled out, this is of concern. To exclude the possibility that recombinant E proteins of ZIKV might induce ADE in infections with related flaviviruses, we performed an immunization study with an insect-cell derived E protein containing four mutations in and near the FL. Our data show that this mutant antigen elicits antibodies with equal neutralizing capacity as the wildtype equivalent. However, it induces much less serological cross-reactivity and does not cause ADE in vitro. These results indicate that mutated variants of the E protein might lead to ZIKV and other flavivirus vaccines with increased safety profiles.
Carprofen Permeation Test through Porcine Ex Vivo Mucous Membranes and Ophthalmic Tissues for Tolerability Assessments: Validation and Histological Study
Authors: Gómez-Segura Lidia , Parra Alexander , Calpena Ana C. , Gimeno Álvaro , Boix-Montañes Antonio
Published: October 2020

Carprofen (CP), a non-steroidal anti-inflammatory drug (NSAID), is profusely used in veterinary medicine for its analgesic and anti-inflammatory activity. Some undesirable effects are associated with its systemic administration. Alternative local routes are especially useful to facilitate its administration in animals. The main aim of this paper is to validate the suitability of ex vivo permeation experiments of CP with porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) intended to be representative of naïve in vivo conditions. Chromatographic analysis of CP in membrane-permeated samples and drug-retained have been validated following standard bioanalytical guidelines. Then, recovery levels of drugs in tissue samples were assessed with aqueous phosphate buffered saline (PBS) buffer to preserve the histological integrity. Finally, as a proof of concept, a series of CP permeation tests in vertical Franz diffusion cells has been performed to evaluate permeation flux and permeability constants in all tissues, followed by a histological study for critical evaluation. Furthermore, synthetic tissue retention-like samples were prepared to verify the value of this experimental study. Results show linear relationships with good determination coefficient (R2 > 0.998 and R2 > 0.999) in the range of 0.78 to 6.25 mg/mL and 3.125 mg/mL to 100 mg/mL, respectively. Low limits of quantification around 0.40 µg/mL were allowed to follow permeation levels until a minimum of 0.40% of the locally-applied dose. This method showed a good accuracy and precision with values lower than 2%. After the recovery technique, reproducible values below 30% were achieved in all tissues, suggesting it is a non-damaging method with low efficiency that requires the use of further solvents to enhance the extraction percentages. After permeation and histology tests, no relevant peak interferences were detected, and no cell or tissue damage was found in any tissue. In conclusion, results demonstrate the suitability of this test to quantify the distribution of CP with good histological tolerability.
Humoral Immune Responses to Burkholderia pseudomallei Antigens in Captive and Wild Macaques in the Western Part of Java, Indonesia
Authors: Testamenti Vincentius Arca , Noviana Rachmitasari , Iskandriati Diah , Norris Michael H. , Jiranantasak Treenate , Tuanyok Apichai , Wahyudi Aris Tri , Sajuthi Dondin , Pamungkas Joko
Published: October 2020

Burkholderia pseudomallei, the Gram-negative bacterium which causes melioidosis, is a threat to human and a wide range of animal species. There is an increased concern of melioidosis in Indonesian primate facilities, especially following case reports of fatal melioidosis in captive macaques and orangutans. Our preliminary serosurveillance of immunoglobulin G (IgG) to B. pseudomallei lipopolysaccharide showed that a significant number of captive and wild macaques in the western part of Java, Indonesia, have been exposed to B. pseudomallei. To better characterize the humoral immune response in those animals, a panel of assays were conducted on the same blood plasma specimens that were taken from 182 cynomolgus macaques (M. fascicularis) and 88 pig-tailed macaques (M. nemestrina) reared in captive enclosures and wild habitats in the western part of Java, Indonesia. The enzyme-linked immunosorbent assays (ELISAs) in this study were conducted to detect IgG against B. pseudomallei proteins; alkyl hydroperoxide reductase subunit C (AhpC), hemolysin-coregulated protein (Hcp1), and putative outer membrane porin protein (OmpH). The performances of those immunoassays were compared to ELISA against B. pseudomallei LPS, which has been conducted previously. Seropositivity to at least one assay was 76.4% (139/182) and 13.6% (12/88) in cynomolgus macaques and pig-tailed macaques, respectively. Analysis of demographic factors showed that species and primate facility were significant factors. Cynomolgus macaques had higher probability of exposure to B. pseudomallei. Moreover, macaques in Jonggol facility also had higher probability, compared to macaques in other facilities. There were no statistical associations between seropositivity with other demographic factors such as sex, age group, and habitat type. There were strong positive correlations between the absorbance results of AhpC, HcpI, and OmpH assays, but not with LPS assay. Our analysis suggested that Hcp1 assay would complement LPS assay in melioidosis serosurveillance in macaques.
Measuring Student and Staff Satisfaction with the University Facilities
Authors: Derbali Abdelkader , Elnagar Ahmed K
Published: October 2020

Today in the world, service companies are always concerned with the quality of services, which is used by many universities to increase their competitiveness under conditions of fierce competition. Universities, therefore, think of students as their main clients, as well as seek teachers and administrators’ satisfaction by improving the quality of their services (Nguyen, 2012). The purpose of this article is to evaluate the quality of services offered by the Community College in Taibah University to its students and staff. The data are collected by questioning a sample of 281 respondents in the Community College at Taibah University during the 2018-2019 academic year. A descriptive analysis is used to define the variables of our study, and the principal component analysis (PCA) is applied to determine the contribution of each variable as a factor that affects the respondents’ preferences. The principal component analysis method captures the key variables of the staff satisfaction at the Community College in Taibah University regarding the services provided. The empirical findings of this study let the authors show that the student and staff satisfaction of the Community College in Taibah University is related to certain factors which constitute a necessity for respondents of both genders. These results serve as benchmarks to allow managers of the institution to improve the quality of their services.
División, objeto y abstracción de las ciencias especulativas según Francisco Suárez
Authors: Mendoza José María Felipe
Published: October 2020

Durante los últimos decenios del siglo XX la filosofía de Francisco Suárez fue considerada parte integrante de un movimiento escolástico comúnmente mencionado como escuela tomista. La perspectiva de abordaje, según el mote impuesto, colocaba la posición especulativa del Dr. Eximio más próxima al dominico Tomás de Aquino de acuerdo con los siguientes matices: a. en el ámbito epistémico la figura del Aquinate eclipsaba ampliamente aquella de Suárez, promoviendo una auténtica desconsideración de sus tesis originales; b. el jesuita español fundaba, igual que Tomás de Aquino, la división de las ciencias especulativas en el acto intelectual de abstracción; c. la diferencia entre ambas concepciones metafísicas no implicaba necesariamente una comprensión epistémica distinta. Ahora bien, contra estas interpretaciones aparece en el siglo XXI otra lectura, donde se acentúa la diferencia decisiva de la filosofía del jesuita del siglo XVI, quien, en letras medievales, escribe y piensa en permanente tensión entre la herencia de la filosofía antigua y medieval por una parte, y una neo-escolástica de aires renacentistas por la otra. De acuerdo con ello, si bien su pensamiento discurre por una tradición aristotelizante del saber, la comprensión de las ciencias se asienta, a diferencia de Tomás de Aquino, en clave objetiva. Sobre esta premisa, el siguiente estudio abordará con exclusividad la originalidad epistémica de Suárez según la división de las ciencias especulativas y reales, mostrando el orden, el principio y las relaciones entre las ciencias física, matemática y metafísica.
La palabra como instancia terapéutica de la acedia en Evagrio Póntico. La salmodia frente al logismós de la incuria
Authors: Vázquez Santiago Hernán
Published: October 2020

Evagrio Póntico es uno de los primeros grandes sistematizadores de la espiritualidad cristiana y, por lo mismo, de gran importancia en diversos desarrollos antropológicos y de espiritualidad en el medioevo. El tópico de la acedia resulta un ejemplo de ello. El presente trabajo examina esta concepción evagriana de acedia de acuerdo a algunas claves hermenéuticas otorgadas por dos de los estudiosos más importantes del pensamiento del Póntico. Una vez clarificado el concepto de acedia, avanza en la dilucidación del recurso de la palabra como instancia terapéutica, principalmente de la palabra de la salmodia. La acedia es, consecutivamente, incuria o descuido, λογισμός tentador y desborde pasional, que impulsan a abandonar la vida del espíritu. Frente a ello, la palabra de la salmodia se erige en un importante recurso terapéutico para aquietar las pasiones, refutar los pensamientos y restaurar la esperanza.
REAL TIME MONITORING OF SMART GREENHOUSE ENVIRONMENT USING IOT FOR SUSTAINABLE AGRICULTURE
Authors: Tiwari Sadhana , Sharma Neha
Published: October 2020

Nowadays, the Wireless Sensors Network (WSN) and the Internet of Things (IoT) are widely used in providing decision support systems which solve many problems in the real-world. A greenhouse is a structure made mainly of transparent material, in which plants are grown in a controlled manner. Traditional method of monitoring greenhouse involves human labor and is very time consuming process. The proposed method deals with the scope of IoT based greenhouse technology in agriculture field for efficiently cultivating various crops irrespective of the geographical and environmental conditions. The IoT based greenhouse technology can provide control environment for high value crops like flowers, medicinal plants, etc. throughout the year to gain maximum profit. The greenhouse environmental parameters are continuously sensed using different parameters sensors and the collected data is displayed on a customized website.
TRIGEMINAL NEURALGIA AND ITS RECENT ADVANCES
Authors: Nithyanand R.
Published: October 2020

Despite recent advances in understanding and treating trigeminal neuralgia, its management remains a considerable challenge. Better classification of different types of facial pain and the identification of prognostic factors for different treatment options lead the way toward better quality of life for the individual patient. Although the principles of treating trigeminal neuralgia remain basically the same, antiepileptic drugs, muscle relaxants, and neuroleptic agents are widely used medical treatment options. They were not originally developed for treating trigeminal neuralgia. Carbamazepine was studied in adequate placebo-controlled clinical trials in the 1960s and is still considered the most effective drug.
Among emerging treatment options currently under clinical investigation are local botulinum neurotoxin type A injections and a novel sodium channel blocker (CNV1014802) that selectively blocks the Nav1.7 sodium channel. Non-pharmacological treatment options are non-invasive electrical stimulation with either transcranial direct-current stimulation or repetitive transcranial magnetic stimulation which both require further evaluation in regard to applicability. Surgical options remain a valid choice for patients not responding to medical treatment and include Gasserian ganglion percutaneous techniques, gamma knife surgery, and microvascular decompression. There is continual effort to improve these techniques and predict the outcome for better patient selection.
A STUDY ON MENTAL HEALTH AND LIFE SATISFACTION AMONG MANAGEMENT STUDENTS
Authors: Perween Neha
Published: October 2020

The present study aims to investigate the impact of gender and religion on mental health and life Satisfaction among management students. The sample was consisted of 100 management students selected by stratified random sampling from different institutions located in Ranchi town. The stratification was based on two groups of gender (Boys & girls) and religion (Hindu and Muslim). In total, there were four sample sub - groups based on 2 x 2 factorial design and for each sample sub- group, 25 cases were selected randomly. General Health Questionnaire (GHQ)-12 by Shamsunder et al. (1986) and Goutam et al. (1987) was applied to measure the level of mental health and Life Satisfaction Scale by Alam (2001) was used to find out the level of life satisfaction among the student sample. ANOVA and Correlation were used to analyze the data by SPSS. The results revealed that there was no significant effect of gender and religion on mental health and life satisfaction of the students. And co-relation between mental health and life satisfaction was found significant.
Attitudes of surgeons toward the treatment and prosthetic rehabilitation of oral cancer patients – A questionnaire survey in central India
Authors: Kudwe Baban , Wankhade Sattyam , Khalikar Arun , Deogade Suryakant , Shaikh Almas
Published: October 2020

Aim: To investigate the knowledge and attitude of surgeons toward the treatment and prosthetic rehabilitation of cancer patients in central India
Settings and Design: Descriptive survey
Materials and Methods: The survey was conducted by a printed questionnaire with 13 close-ended questions, distributed among 80 surgeons from different specialities practicing in different locations of central India. The responses were collected by personal visits to the participants and analysed.
Results: Approximately more than one-half (67.5%) of the participants performed maxillary resections, and only 19.2% of the participants surgically reconstructed the maxillary defects in 75–100% of the treated cases. Furthermore, although all the participating surgeons believed in a multidisciplinary team approach and dental rehabilitation following surgical reconstructions, only 64% of them obtained pre-surgical dental evaluations from a prosthodontist. Moreover, although 97.5% of them communicated with a prosthodontist for prosthetic rehabilitation, only 2.5% of them got almost all their cases rehabilitated with a definitive prosthesis.
Conclusion: The current practice trends of the surgeons in central India dealing with oral cancer patients indicate that although having a belief in a multidisciplinary team approach, the surgeons for some reasons have being exhibiting reluctance toward accessing the services of a prosthodontist and prosthetic rehabilitation of the treated oral cancer patients.
Noninteger Dimensional Spaces and the Inverse Square Law
Authors: Kak Subhash
Published: October 2020

Noninteger dimensionality, which shows up in many fields of physics and engineering, is generally viewed from the perspective of fractals and measured by the Hausdorff dimension. Motivated by information theoretic considerations and by extending the principle of complementarity, we propose a new interpretation in which it engenders a potential. The inverse square law may then be seen to originate from the properties associated with the noninteger dimensional space, and it further indicates a relationship between the dynamics and the actual value of the dimensions that may be used for experimental test of the interpretation.
PAULO FREIRE E O PÓS-COLONIALISMO NA EDUCAÇÃO POPULAR LATINO-AMERICANA
Authors: Mota Neto João Colares da
Published: October 2020

Este ensaio busca analisar como se apresenta a concepção pós-colonial ao longo das obras pedagógicas de Paulo Freire. O artigo foi construído com base em pesquisa bibliográfica, que focalizou obras representativas dos diversos momentos da produção intelectual de Paulo Freire, além do estudo de autores representativos da teoria pós-colonial. Conclui-se que a matriz pós-colonial acompanhou as obras de Paulo Freire, desde os seus primeiros trabalhos – em que o colonialismo era visto como um entrave ao desenvolvimento democrático da Nação, passando pelos “escritos africanos” e seu engajamento concreto nas lutas anticoloniais – até os seus últimos trabalhos, em que estava já bastante familiarizado com a crítica epistemológica à modernidade.
LEGADO DE PAULO FREIRE À EJA DA ESCOLA CABANA
Authors: Dias Alder Sousa
Published: October 2020

Neste artigo, analisa-se a influência da pedagogia de Paulo Freire na Escola Cabana, com ênfase na Educação de Jovens e Adultos (EJA). Tem por base uma dissertação de mestrado concluída em 2012, no Programa de Pós-Graduação em Educação da UEPA, vinculada a um projeto interinstitucional da Cátedra Paulo Freire da PUC/SP. A pesquisa consiste em uma investigação qualitativa. Os sujeitos são quatro profissionais da educação, que, no período da Escola Cabana, atuaram na EJA. Entre as estratégias metodológicas, estão o levantamento bibliográfico e documental e a aplicação de entrevistas narrativas com os sujeitos da pesquisa. A sistematização e análise dos dados foram construídas com base na Análise de Conteúdo. Palavras-chave: Paulo Freire. Escola Cabana. Educação de Jovens e Adultos. Entrevistas narrativas. Análise de Conteúdo.
RASTREIO COGNITIVO E FUNCIONAL DE IDOSOS INSTITUCIONALIZADOS COM HISTÓRICO DE QUEDAS
Authors: Almeida Tomáz Benjamin Costa de , Oliveira Abner Vinícius Rolim de , Silva Tatiane Bahia do Vale , Moraes Suellen Alessandra Soares de
Published: October 2020

Objetivo: Investigar associação entre cognição e funcionalidade de idosos institucionalizados que sofreram ou não quedas. Métodos: Foram avaliados 68 idosos de duas instituições públicas de longa permanência, de Belém/PA. Foi utilizado, o Mini Exame do Estado Mental (MEEM) para o rastreio cognitivo, e para funcionalidade, o índice de Katz ou Avaliação de incapacidade para demência (Disability Assessment For Dementia – DAD), na presença de déficit cognitivo. Na análise estatística foram utilizados o Teste Exato de Fisher, teste G, Teste t de Student e coeficiente de correlação de Pearson ou Spearman para investigação das associações, considerando um nível de significância de 5%. Resultados: Os idosos avaliados tinham entre 60 e 97 anos, dos quais 13 sofreram quedas. Não houve associação significativa das quedas com o grau de escolaridade, declínio cognitivo e capacidade funcional. Entretanto, o maior número de comorbidades (p = 0,0172) e a percepção subjetiva da visão (p = 0,0131) estiveram significativamente associadas a quedas. O declínio cognitivo e o comprometimento funcional não diferiram entre os grupos estudados. Conclusão: O prejuízo visual e múltiplas comorbidades podem estar associados às quedas; por outro lado, os déficits cognitivos e funcionais não apresentaram associação entre os grupos para a população investigada.
PERFIL DO USUÁRIO E FATOR MOTIVACIONAL PARA PRÁTICA DA LUTA EM ACADEMIAS DA CIDADE DE PORTO VELHO – RO
Authors: Godim Franclin Serra , Passos Ricardo Pablo , Silio Luís Felipe , Camacho Naiara Triverio , Neto Manoel Lourenço , Almeida Érika de Araújo , Oliveira José Ricardo Lourenço de , Oliveira Heleise Faria dos Reis de , Pereira Adriano de almeida , Vilela Junior Guanis de Barros , Bernaldino Elizângela de Souza
Published: October 2020

A presente pesquisa tem como objetivo analisar o perfil do usuário e fator motivacional para prática da luta em academias da cidade de porto velho. Para tanto foi realizada uma pesquisa do tipo descritiva com abordagem qualitativa, junto aos praticantes de lutas maiores de 18 anos oriundos de 03 (três) academias localizadas em locais distintos da cidade de Porto Velho – RO. Como instrumentos de coleta de dados serão utilizado um questionário estruturado pelo pesquisador com 10 questões mistas. A pesquisa foi submetida ao Comitê de Ética em Pesquisa e após sua aprovação, estima-se a realização da pesquisa com quantitativo de 15 praticantes por academia selecionada para pesquisa, perfazendo assim um quantitativo geral de 45 praticantes de lutas regularmente matriculados e ativos nos programas de treino da academia. Para análise dos dados foi utilizada a estatística inferencial ou indutiva, (inferencial onde se utiliza as informações de uma amostra para chegar a conclusões sobre um grupo). Em síntese, espera-se que a identificação dos fatores motivacionais para adesão e permanência da luta contribua para melhoria do atendimento e oferta dos diferentes tipos de lutas nas academias participantes da pesquisa na cidade de Porto Velho, bem como que os resultados possibilitem fazer apontamentos referentes à necessidade da buscar de qualificação dentro a área em questão para que assim seja possível atender as especificidades desta clientela.
PERCEPÇÃO DE PROFISSIONAIS E ACADÊMICOS DE EDUCAÇÃO FÍSICA SOBRE O TREINAMENTO CROSSFIT NA CIDADE DE PORTO VELHO-RO
Authors: Silva Vanessa Rityele Moura da , Passos Ricardo Pablo , Silio Luís Felipe , Almeida Érika de Araújo , Lima Luis Fernando de Oliveira , Oliveira José Ricardo Lourenço de , Oliveira Heleise Faria dos Reis de , Fileni Carlos Henrique Prevital , Vilela Junior Guanis de Barros , Bernaldino Elizângela de Souza
Published: October 2020

A presente pesquisa teve por objetivo conhecer a percepção dos profissionais de Educação Física acerca da modalidade esportiva CrossFit da cidade de Porto Velho – RO. Para tanto foi realizada uma pesquisa de campo do tipo descritiva com 20 profissionais e estudantes de Educação Física que atuam em academias e/ou Box de CrossFit na cidade de Porto Velho – RO. Como instrumentos de coleta de dados utilizou-se um questionário estruturado com 10 (dez) questões mistas. A pesquisa foi submetida ao Comitê de Ética em Pesquisa e mediante sua aprovação a coleta de dados foi iniciada junto aos profissionais de Educação Física e/ou estudantes em horário previamente acordado (antes e/ou após o horário de trabalho). Para análise dos dados recorreu-se a estatística descritiva percentual para análise do objeto “conhecimento sobre os benefícios do treinamento de alta intensidade”. Como resultados predominantes: quanto ao conhecimento da modalidade e dos fundamentos: obteve-se (100%) de respostas afirmativas no grupo de acadêmicos e profissionais CrossFit (CF); e respectivamente (93,3%) e (60%) no grupo de acadêmicos e profissionais de academias (AC). Referente ao risco de lesões: (100%) do grupo CF afirmaram ser passivo de lesão como qualquer outra modalidade; e (60%) do grupo AC destacaram que tem risco eminente de lesão. Sobre a forma como tomou conhecimento do CF: no grupo CF (40%) em competições, enquanto que no grupo AC, (33,3%) relataram que conheceram a modalidade por meios diversificados. Em relação à afirmação de que a modalidade ocupa o espaço de outra área, ambos os grupos apontaram que não (60% no CF e 87,6 no AC). No que diz respeito à percepção dos grupos sobre o treinamento CF: no grupo CF (80%) revelaram ser um novo campo de atuação; no grupo AC (40%) afirmaram que tem objetivos diferentes do convencional. Em se tratando dos benefícios e motivos para adesão e permanência ao CF: houve unanimidade acerca dos benefícios do CF para saúde (100%); (40%) apontaram que aderiram por conta da eficiência dos resultados; (40%) permanecem pelo senso da comunidade no ambiente do CF. Em síntese, os achados a respeito dos profissionais sobre a modalidade CF mostrou que o CF não é mal visto pelos profissionais de musculação, entretanto há necessidade de maiores esclarecimento e discussões referentes aos riscos relacionados a lesões e a metodologia de treinamento CF, atingindo assim o objetivo primário da pesquisa.
POPULATION KNOWLEDGE ABOUT PREVENTIVE MEASURES AGAINST SARS-COV-2 (COVID-19) IN NORTHERN PARANÁ – BRAZIL
Authors: Erthal Danielle Pires , Erthal Rafaela Pires , Foggiato Augusto Alberto , Neto João Lopes Toledo , Silva Douglas Fernandes
Published: October 2020

SARS-CoV2 has characteristics that are still unknown and therefore untreated. This disease demands efficient biosafety practices for professionals and the population considering the high infectivity rate of these viruses. The objective of this work was to evaluate the knowledge of the population of Northern Paraná - Brazil about the methods indicated for the prevention and reduction of the risk of infections in the midst of the COVID-19 pandemic. A field research was carried out in the form of a cross-sectional design with the participation of 137 respondents. A questionnaire was applied through Google Forms, the data collected were evaluated using the IBM SPSS Statistics software (version 25) and the dependence of the variables through Pearson's Chi-square test. In this work it was concluded that the population was conscious about the importance of prevention, forms of contagion and symptoms related to the Pandemic caused by SARS-CoV-2. In addition, individuals observe professional ethics regarding infection prevention. The mechanisms for seeking health services are not yet clear to the general population. Finally, information on health prevention should be better understood by the population, since health professionals have less infectious diseases.
Participación de la sociedad civil en el derecho de acceso a la información pública
Authors: Morales Tostado María del Carmen , Monterde Valenzuela María de los Ángeles , Morales Tostado Reyna Guadalupe
Published: October 2020

En la presente investigación, se revisa el marco legal de la transparencia y el derecho de acceso a la información pública, iniciado desde los antecedentes del derecho humano a la información desde una perspectiva internacional. Así mismo, la evolución que ha tenido la estructura legal de la transparencia y derecho a la información pública, brinda seguridad jurídica a los ciudadanos para que puedan acceder a la información que les interese de las gestiones y desempeño del gobierno. También, se revisa el proceso de construcción de ciudadanía, donde el derecho de acceso a la información cobra vital importancia y se investiga el número de solicitudes que han realizado al Instituto Nacional de transparencia, acceso a la información y protección de datos personales (INAI) de 2003 a 2019.
Gobierno abierto: Transparencia y acceso a la información en la administración de losrecursos materiales
Authors: Navarro Olea Dalia
Published: October 2020

El objetivo de este documento es realizar un análisis bibliográfico de resultados derivados de la implementación de los lineamientos normativos establecidos en materia de transparencia y acceso de información relacionados con la Administración de los Recursos Materiales.
Analisis Kinerja Keuangan Terhadap Pertumbuhan Laba Pada Perusahaan Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia Tahun 2013-2017
Authors: Ridwan
Published: October 2020

Pertumbuhan perusahaan menjadi faktor penentu dalam konteks berinvestasi. Perusahaan makanan dan minuman menjadi kategori industri yang sangat strategis khususnya di Indonesia. Sektor ini juga menjadi penyumbang terbesar Produk Domestik Bruto (PDB) dalam kurun waktu beberapa tahun. Penelitian ini bertujuan untuk menganalisis kinerja keuangan yang terdiri dari rasio cepat, rasio utang terhadap ekuitas, total perputaran aset, margin laba bersih secara parsial terhadap pertumbuhan laba perusahaan sub sektor makanan dan minuman yang terdaftar di BEI periode 2013-2017. Penelitian ini termasuk jenis kuantitatif. Sumber data yang digunakan adalah data sekunder berupa laporan keuangan tahunan perusahaan. Teknik sampling yang digunakan adalah purposive sampling, dan sampel sebanyak 11 perusahaan makanan dan minuman. Metode analisis data menggunakan statistik deksriptif, analisis regresi data panel, dan uji asumsi klasik. Hasil penelitian menunjukkan pertumbuhan laba dapat dipengaruhi rasio cepat, rasio utang terhadap ekuitas, total perputaran aset, dan margin laba bersih sebesar 13,26% dan 86,74% dijelaskan variabel diluar variabel yang diteliti
Manajemen Pembelajaran dalam Meningkatkan Efektivitas Proses Belajar Mengajar di Masa Pandemi Covid-19
Authors: Saifulloh Ahmad Munir , Darwis Mohammad
Published: October 2020

Menajemen pembelajaran sangat penting kedudukannya dalam rangka meningkatkan efektivitas proses belajar mengajar, apalagi di masa darurat penyebaran Corona Virus Disease 19 (COVID-19) seperti yang kita alami saat ini. Berbagai usaha dilakukan untuk meningkatkan kualitas pendidikan dengan tetap mempertimbangkan protokol kesehatan sesuai dengan SKB 4 Mentri. Berbagai hambatan, kesulitan, dan keterbatasan dihadapi dalam proses belajar mengajar, mulai dari faktor peserta didik, keluarga peserta didik, maupun sarana dan prasarana yang kurang representatif, namun kementrian pendidikan dan kebudayaan (kemendikbud) tetap menginstruksikan seluruh pendidik di semua jenjang pendidikan agar dapat menciptakan pembelajaran yang menyenangkan dari rumah baik siswa maupun mahasiswa. Oleh karena itu, peran guru sangat dibutuhkan dalam memanage atau mengelola pembelajaran mulai dari perencanaan (planning), pengorganisasian (organizing), pelaksanaan (actuating) dan evaluasi (evaluating) dalam rangka meningkatkan efektivitas proses belajar mengajar di masa pandemi covid 19 saat ini, baik implementasi pembelajaran jarak jauh (PJJ) dalam jaringan (daring) maupun luar jaringan (luring).manajemen pembelajaran
Diagnosis and treatment of dyssomnic impairment in patients with anxiety-depressive disorders (literature review).
Authors: Yuryeva Liudmyla , Liashchenko Yuliia
Published: October 2020

Sleep disorders are one of the most common complaints in patients seeking medical attention. In turn, dyssomnic disorders are often associated with other somatic and mental illnesses. The greatest comorbidity of sleep disorders is seen with anxiety and depressive disorders. The relationship, which is defined as bi-directional and can aggravate the course of each other, as well as affect the results of treatment and the occurrence of relapse in the future. The purpose of this article was to conduct a systematic literature review of a number of studies related to the study of the relationship between anxiety-depressive disorders and sleep disorders, assessment features and existing therapeutic approaches. As a result of a systematic literature search, 25 studies were selected for further analysis. The inclusion criteria were the availability of information on the mutual influence of sleep disorders on the course of states of the anxiety-depressive spectrum, methods of monitoring and self-monitoring sleep disorders in patients, as well as approaches of pharmacological and psychotherapeutic influence. Most studies reported the successful use of psychoeducational work, cognitive-behavioral therapy (individual, group), and person-centered psychotherapy to correct sleep in patients, and it was noted that sleep recovery led to a significant improvement in comorbidity. It was also found that the most studied sleep disorders were in depressive disorder, while the relationship and methods of correcting dyssomnias in anxiety disorders have not been studied enough. Thus, further research aimed at expanding the methods of sleep correction in anxiety states and the creation of appropriate differentiated rehabilitation programs for the treatment of patients with anxiety-depressive disorders with sleep disorders would make a significant contribution to the development of clinical medical, psychological and psychiatric practice.
Key words: depression, dyssomnia treatment, psychopharmacotherapy, psychotherapy, sleep disorders, anxiety