bluuebunny/crossref_metadata_2025 huggingface dataset:
Health related quality of life among Rheumatic Fever and Rheumatic Heart Disease patients in India
Authors: Dixit Jyoti , Jyani Gaurav , Prinja Shankar , Sharma Yashpaul
Published: October 2021

Background

Measurement of health-related quality of life (HRQOL) of people with chronic illnesses has become extremely important as the mortality rates associated with such illnesses have decreased and survival rates have increased. Thereby, such measurements not only provide insights into physical, mental and social dimensions of patient’s health, but also allow monitoring of the results of interventions, complementing the traditional methods based on morbidity and mortality.

Objective

The present study was conducted to describe the HRQOL of patients suffering from Rheumatic Fever (RF) and Rheumatic Heart Disease (RHD), and to identify socio-demographic and clinical factors as predictors of HRQOL.

Methodology

A cross-sectional study was conducted to assess the HRQOL among 702 RF and RHD patients using EuroQol 5-dimensions 5-levels instrument (EQ-5D-5L), EuroQol Visual Analogue Scale and Time Trade off method. Mean EQ-5D-5L quality of life scores were calculated using EQ5D index value calculator across different stages of RF and RHD. Proportions of patients reporting problems in different attributes of EQ-5D-5L were calculated. The impact of socio-economic determinants on HRQOL was assessed.

Results

The mean EQ-5D-5L utility scores among RF, RHD and RHD with Congestive heart failure patients (CHF) were estimated as 0.952 [95% Confidence Interval (CI): 0.929–0.975], 0.820 [95% CI: 0.799–0.842] and 0.800 [95% CI: 0.772–0.829] respectively. The most frequently reported problem among RF/RHD patients was pain/discomfort (33.8%) followed by difficulty in performing usual activities (23.9%) patients, mobility (22.7%) and anxiety/depression (22%). Patients with an annual income of less than 50,000 Indian National Rupees (INR) reported the highest EQ-5D-5L score of 0.872, followed by those in the income group of more than INR 200,000 (0.835), INR 50,000–100,000 (0.832) and INR 100,000–200,000 (0.828). Better HRQOL was reported by RHD patients (including RHD with CHF) who underwent balloon valvotomy (0.806) as compared to valve replacement surgery (0.645).

Conclusion

RF and RHD significantly impact the HRQOL of patients. Interventions aiming to improve HRQOL of RF/RHD patients should focus upon ameliorating pain and implementation of secondary prevention strategies for reducing the progression from ARF to RHD and prevention of RHD-related complications.
Karakter Morfologi Dan Anatomi Sawilangit (Vernonia Cinera L.) Pada Ketinggian Yang Berbeda
Authors: Lestari Sri , Palupi Dian , Aryani Riska Desi
Published: October 2021

Vernonia cinerea L. (sawilangit) is a wild plant that has potential as a medicinal plant because of the secondary metabolites in each organ. This research aimed to explore the morphological and anatomical characters of the sawilangit that grow at different altitudes in Banyumas, Cilacap, and Purbalingga. Plant samples were taken using the purposive random sampling method at an altitude of <350 masl, 350–700 masl, and >700 masl. Sawilangit growing at <350 masl has superior morphological and anatomical characters than sawilangit growing at the other two altitudes, which have the characteristics of taller, wider leaf, larger stem diameters, and darker flower color. The observation on quantitative of morphological and anatomical characters showed that sawilangit at <350 masl has an average height of 66.17 cm, root diameter of 0.33 cm, stem diameter 0.32 cm, leaf length and width of 5.7 cm and 2.14 cm, and stomata index of 0.28. These results indicated that altitude <350 masl is suitable for sawilangit growth because it can produce optimal morphological and anatomical characteristics.
Bioprospection of Enggano Macroscopic Fungi as Antibacterial and Antioxidant Agents
Authors: Evana Evana , Palupi Kartika Dyah , Oktavia Listiana , Fathoni Ahmad
Published: October 2021

Macrofungi in Indonesia have not been widely studied for their pharmacological activity, especially as a source of antibacterial and antioxidant properties, even though Indonesia as a tropical country has quite a high diversity of macrofungi. This study aims to reveal the potential of macrofungi from the Enggano forest as a source of antibacterial and antioxidant compounds. Four types of macrofungi were collected and their metabolites were extracted using four types of organic solvents. Antibacterial and antioxidant activity assay of the extract was carried out using the TLC Bioautography method. From the sixteen macrofungal extracts, there is one extract that has the strongest antibacterial activity compared to the others, namely n-hexane Coriolopsis polyzona. It showed moderate antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 256–128 μg/mL, respectively. Meanwhile, the antioxidant activity of the macrofungal extracts showed weak activity with IC50 values of 3080–7370 μg/mL (AAI values of 0.033–0.079).
Higher order stroboscopic averaged functions: a general relationship
with Melnikov functions
Authors: Novaes Douglas
Published: October 2021

In the research literature, one can find distinct notions for higher order averaged functions of regularly perturbed non-autonomous
T-periodic differential equations of the kind x′=ε
F(t,x,ε

). By one hand, the classical (stroboscopic) averaging method provides asymptotic estimates for its solutions in terms of some uniquely defined functions gi's, called averaged functions, which are obtained through near-identity stroboscopic transformations and by solving homological equations. On the other hand, a Melnikov procedure is employed to obtain bifurcation functions fi's which controls in some sense the existence of isolated T-periodic solutions of the differential equation above. In the research literature, the bifurcation functions fi's are sometimes likewise called averaged functions, nevertheless, they also receive the name of Poincaré–Pontryagin–Melnikov functions or just Melnikov functions. While it is known that
f1=Tg1, a general relationship between gi and fi is not known so far for i≥
2. Here, such a general relationship between these two distinct notions of averaged functions is provided, which allows the computation of the stroboscopic averaged functions of any order avoiding the necessity of dealing with near-identity transformations and homological equations. In addition, an Appendix is provided with implemented Mathematica algorithms for computing both higher order averaging functions.
A case of X-linked Charcot-Marie-tooth disease type 1 manifesting as recurrent alternating hemiplegia with transient cerebral white matter lesions
Authors: Kang Minsung , Hwang Sun-Jae , Shin Jin-Hong , Kim Dae-Seong
Published: October 2021

X-linked Charcot Marie Tooth disease type 1 (CMTX1) is a clinically heterogenous X-linked hereditary neuropathy caused by mutation of the gene encoding gap junction beta 1 protein (GJB1). Typical clinical manifestations of CMTX1 are progressive weakness or sensory disturbance due to peripheral neuropathy. However, there have been some CMTX1 cases with accompanying central nervous system (CNS) manifestations. We report the case of a genetically confirmed CMTX1 patient who presented recurrent transient CNS symptoms without any symptom or sign of peripheral nervous system involvement.
A case of motor and sensory polyneuropathy induced by primary hyperparathyroidism
Authors: Lee Mina , Kim Hye Jeong , Roh Hakjae
Published: October 2021

Primary hyperparathyroidism (PHP) is a disease in which excessive amounts of parathyroid hormone (PTH) are secreted and calcium levels in the blood increase. Hypercalcemia caused by PHP has a major influence on the peripheral nervous system and produces symptoms such as muscle cramps, paresthesia, and proximal muscle weakness. Here we report a rare case of sensory-dominant polyneuropathy caused by PHP, which improved after surgery.
História da Educação Rural: formação e trabalho docente no Brasil no Século XX
Authors: Leite Kamila Cristina Evaristo , Silva Tiago Rodrigues da
Published: October 2021

Com a imagem de uma escola rural de Itapetininga, interior do Estado de São Paulo, do início dos anos 1930, a obra, História e memória da educação rural no século XX , lançado em 2020, estampa a representação cultural da educação rural no país: a professora em uma casa improvisada para o estabelecimento de ensino das primeiras letras, com as salas multiseriadas e os alunos descalços. O livro resenhado reúne reflexões de um grupo de pesquisadores de distintos estados brasileiros que se ocuparam da formação e trabalho docente de professoras primárias rurais, no período compreendido entre 1930 a 1970, na perspectiva transversal, conectando o regional com o nacional, com as proposições da História Cultural e as abordagens da História e Educação Comparada. Rosa Fátima de Souza Chaloba, Macioniro Celeste Filho e Ilka Miglio de Mesquista foram os responsáveis pela organização da obra com resultados do projeto de pesquisa nacional “Formação e Trabalho de Professoras e Professores Rurais no Brasil: RS, PR, SP, MG, RJ, MS, MT, MA, PE, PI, SE, PB, RO (décadas de 40 a 70 do século XX)”. A pesquisa, coordenada por Rosa Fátima de Souza Chaloba, com financiamento do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) objetivou compreender no âmbito do nacional e regional a formação do magistério rural e o trabalho docente (recrutamento, salários, carreira, etc.) em meados do século XX. A equipe do projeto contou com 18 instituições de ensino superior do país, envolvendo pesquisadores de reconhecida liderança no campo de História da Educação. Na assessoria internacional, houve intensa participação de Oresta López Péres, professora-pesquisadora titular do El Colegio de San Luis (COLSAN), em San Luis Potosi, México, assinando o prólogo “Processos históricos de construcción de identidade y resistencia de la educación rural en Brasil durante el siglo XX”.
Educação e transformação social em Iván Illich, Paulo Freire e Ernesto Guevara
Authors: Silva Eva Aparecida da
Published: October 2021

A análise dos escritos diversos – livros, artigos e outros textos – de três pensadores la-tino-americanos foi como Andrés Donoso Romo escolheu se aprofundar no pensamento lati-no-americano contemporâneo, detendo-se especialmente no papel da educação como o cami-nho para sociedades mais justas. Os pensadores escolhidos para a reflexão foram o austríaco-mexicano Iván Illich (1926-2002), o brasileiro Paulo Freire (1921-1997) e o argentino-cubano Ernesto Guevara (1928-1967), considerando que suas propostas de educação são entendidas como forma de transformação social e também por terem se tornado referências importantes para as correntes de pensamento às quais se filiavam. O conjunto de ideias, concepções e in-terpretações compartilhado pela população da América Latina encontra-se bem retratado nas obras de seus principais pensadores, devidamente contextualizadas e analisadas em suas con-vergências e divergências neste livro. Esta obra resulta das pesquisas do autor sobre a relação entre educação e transformação social no pensamento latino-americano de Iván Illich, Paulo Freire e Ernesto Guevara, no contexto da América Latina das décadas de 1950 a 1970, principalmente, o que nos permite compreender as idéias e propostas educativas elaboradas por esses pensadores no período mais efervescente da história latino-americana. Ela está organizada em três partes, sendo as duas primeiras subdivididas em três capítulos e a terceira composta por um capítulo único, totalizando, portanto, sete envolventes capítulos.
Comparative Anthroponomastics
Authors: Seide Marcia Sipavicius
Published: October 2021

The emergence of onomastic studies in Europe dates back to the 19th century when language studies were made according to the approaches of Philology and Comparative Grammar. However, the interest in comparing anthroponymies of different languages and/or cultures, is recent and even more recent is the perception that studies of this nature form a specific subarea that I call Comparative Anthroponomastics. In this work, I elucidate how this subarea is configured from theoretical, pragmatic epistemological and applied points of view. To this purpose, I present results of bibliographic research based on 16 papers published in International Congresses of Onomastics from 2011 to 2018 and, 06 researchers conducted by me and/or, colleagues in this area totaling 22 studies.
Pela conquista de direitos e efetivação de projetos
Authors: Victor Fabiana Borges
Published: October 2021

Este trabalho tem como objetivo analisar as reivindicações da luta pela terra a partir das manifestações promovidas pelos movimentos socioterritoriais no estado de Minas Gerais, considerando os espaços apropriados pelos manifestantes e também os grupos envolvidos. Para o estudo, são utilizados os registros coletados e sistematizados em bancos de dados referentes aos conflitos no campo e ao processo de luta pela terra no Brasil, especificamente o Banco de Dados da Luta pela Terra - DATALUTA, além de entrevistas junto a dois integrantes de movimentos socioterritoriais. As questões abordadas neste trabalho indicam que estes sujeitos se organizam, unem forças e se articulam pautados na experiência do cotidiano e na formação política, sendo a pressão popular um meio fundamental para se alcançar as mudanças propostas para o campo.
A luta pela terra em Mato Grosso do Sul e a manutenção do latifúndio
Authors: Leonardo Letícia Alves , Luiz Luana Fernanda , Melo Danilo Souza , Nardoque Sedeval
Published: October 2021

Este trabalho deriva de discussões e análises realizadas no Grupo de Estudos Terra e Território (GETT), vinculado ao Laboratório de Geografia Agrária (GEOAGRÁRIA), da Universidade Federal de Mato Grosso do Sul, campus de Três Lagoas (MS) e das ações do projeto DATALUTA/MS, vinculado à Rede DATALUTA nacional. Objetiva-se analisar a questão agrária em Mato Grosso do Sul na atualidade, discutindo dados sobre o uso da terra, estrutura fundiária, luta pela terra e Reforma Agrária, evidenciando os problemas agrários resultantes do processo de ocupação e da conversão de terras públicas e de povos indígenas em terra privada. Fundamenta-se em pressupostos teóricos relacionados aos problemas decorrentes do desenvolvimento do capitalismo no campo e da luta de classes, inerentes à questão agrária. Para subsidiar as discussões, foram utilizados dados sobre ocupações de terras e criação de assentamentos do Banco de dados da Luta pela Terra (DATALUTA). Estes dados, sistematizados em gráficos, possibilitaram a análise da dinâmica da luta pela terra em Mato Grosso do Sul. Somam-se ainda dados sobre a estrutura fundiária obtidos junto ao DATALUTA e uma segunda base georreferenciada do INCRA. Os dados apresentados evidenciam a potência devastadora do monopólio da propriedade capitalista da terra em Mato Grosso do Sul e seus impactos na luta dos movimentos socioterritoriais pela Reforma Agrária.
An Enhanced Performance to Monitor Process Mean with Modified Exponentially Weighted Moving Average – Sign Control Chart
Authors: Taboran Rattikarn , Sukparungsee Saowanit
Published: October 2021

The purpose of this research is to enhance performance for detecting a change in process mean by combining modified exponentially weighted moving average and sign control charts. This is nonparametric control chart which effective alternatives to the parametric control chart so called MEWMA-Sign. The nonparametric control chart can serve when process observations is deviated from normal distribution assumption. Generally, the performance of control charts are widely measured by average run length (ARL) divided into two cases; in control ARL (ARL0) and out of control ARL (ARL1). In this paper, the performance comparison is investigated when processes are non-normal distributions. The performance of the MEWMA-Sign is compared EWMA-Sign control chart by considering from a minimum value of ARL1. The numerical results found that the MEWMASign performs better than EWMA-Sign in order to detect a very small shift of mean process. Additionally, the real application of the MEWMA-Sign and EWMA-Sign are presented.
Tolerancia política en Pierre Bayle
Authors: García-Alonso Marta
Published: October 2021

La doctrina de la tolerancia bayleana suele ser analizada atendiendo a sus componentes morales, no tanto a su articulación política. En este artículo defenderemos que la soberanía indivisible que propone Bayle es indisociable de su doctrina de la tolerancia que implica una estricta separación entre la obligación política y la adhesión religiosa voluntaria, lo que permite, al mismo tiempo, proteger la libertad individual de conciencia y el pluralismo confesional. Por esa razón, entendemos que la tolerancia bayleana está articulada en términos puramente políticos, no religiosos o morales.
Livelihood Improvement through Entrepreneur Characteristics and Innovative Strategies: An Empirical Study of Entrepreneurs in Western Kenya
Authors: Nassiuma Bernard Kibeti , Chebii Pamela , Masinde Jamin , Sergon David
Published: October 2021

Purpose This study aimed at improving an understanding of the mediating role of innovation in the relationship between entrepreneur characteristics and livelihood improvement. The study was empirical, based on primary data from the micro and small enterprises in the western region of Kenya.

Design/methodology study adopted a quantitative approach, self-administered questionnaires were used to gather data from 382 Micro and Small Enterprises (MSEs) owners in Western Kenya, comprising Uasin Gishu and Bungoma Counties. The study examined the direct and indirect effects on livelihood improvement. A simple random sampling technique was used to select respondents for data collection. For statistical analysis, bivariate regression and multiple regression techniques were utilized with SPSS version 26 being the tool. The sopel test assisted in analyzing the effect of innovation as a mediator between entrepreneur characteristics and livelihood improvement.

FindingsThe results reveal a statistically significant relationship between the entrepreneur characteristics and livelihood improvement under the mediating role of innovation.

Practical implications these findings provide useful insights for MSEs, seeking to be competitive and responsive to the changing entrepreneurial landscape by successfully introducing innovations. The study encourages an innovative culture among the MSEs owners which is likely to facilitate the introduction, adoption, and diffusion of innovations that can in turn, result in the achievement of livelihood improvement.

Originality/valueThe study contributes to the existing literature by enhancing an understanding of the mediating role of innovation in the relationship between entrepreneur characteristics and livelihood improvement in the MSEs sector of a developing context.

Keywords: MSEs, innovation, mediation, entrepreneur characteristics, improved livelihood, western Kenya.
Caribbean Faith-Based Organisations: Friend or Foe in the fight against the feminisation of HIV and AIDS in the Anglophone Caribbean
Authors: Hem-Lee-Forsyth Dr. Shivaughn , Thomas Renee
Published: October 2021

The feminisation of HIV and AIDS has become a worldwide phenomenon, and the Caribbean region has not been fortunate enough to be excluded. Caribbean females had 3-4 times higher infection rates than males up to a decade ago. Studies that focus on the contributing psychosocial factors to HIV risk in the Caribbean are limited. This narrative review showcases pivotal work which addresses the reciprocally connected responsibilities of patriarchy and religious practices and how they feed into the desolate reality of Anglophone Caribbean women. The relationship between these cultural issues in the Caribbean, using an anthropological lens, sets a platform for an investigation into HIV and AIDS. This paper seeks to encourage further research centred on the religious elements, which influence heterosexual relationships, and how these relationships are predisposed to potential HIV and AIDS risk. The ultimate goal of this study is to provide English- speaking Caribbean faith-based organisations, public health officials and policymakers a public stage to consider further policy implications for the staggering and disproportionate rates of HIV and AIDS between women and men.
Community Use and Product Valuation of Forest Resources in Maasai Mau
Authors: Koech Charles Kiprono , Njuguna Jane W. , Kiama Stephen M. , Mau James O. , Kaigongi Magrate M. , Muganda Michael M. , Nadir Stanley , Kigomo John N. , Cheboiwo Joshua
Published: October 2021

Forests play an important role in the livelihoods of local people in most developing countries. Local communities depend on forest resources for various products such as fuel wood, construction materials, medicine, and food. The Maasai Mau forest plays an important role in supporting the livelihood of people living around the forest. Exploitation of forest resources should only be limited to active members. To reduce dependency on the forest, alternative means of livelihood should be provided to reduce dependency on the forest.
Public Service Innovation: "SI N'DUK" Program at the Department of Population and Civil Registration Bojonegoro Regency, Indonesia
Authors: Ahmad Suprastiyo Ahmad Suprastiyo
Published: October 2021

ABSTRACT

This research was conducted at the Department of Population and Civil Registration of Bojonegoro Regency. The purpose of this study was to describe and analyze an innovation in population administration services for the Si N'duk application released by the Department of Population and Civil Registration of Bojonegoro Regency. The focus of this study is to describe the innovation of the Si N'duk population administration service application based on the theory of innovation attributes according to Rogers. The research method used is descriptive research using qualitative data analysis techniques. The results of this study indicate that based on the theory of innovation attributes according to Rogers, most of the population administration service innovations in the Si N'duk application have fulfilled this theory. However, there are still some problems, such as those experienced by the community in the process of uploading population document files, then in terms of the application there is still no application form download feature, there is no notification notification when there is a service application, and application upgrades have not been carried out. In addition there are also problems related to servers and networks. Of course, these shortcomings must be corrected in order to continue to provide the best service innovations for the community. Therefore, from the problems that occur, it is necessary to have a routine performance evaluation that must be carried out by the Population and Civil Registration Office of Bojonegoro Regency so that innovation in population administration services through the Si N'duk application can provide more benefits for the community as service recipients.

Keywords: Innovation, Population Administration, Si N'duk Application
The Triomathematics, Trithmetic, Trichometry, Triangulus & Ternary Algebra Expressions that Define the Triophysics and Triological Sciences Related to the Triscalar Mitigation of Non-Ionized Radiation via Bioharmonic Biobalancing Healthy Smart Solar Nanob
Authors: Osler II James Edward Osler II
Published: October 2021

The narrative in this paper provides a detailed and descriptive mathematical model for operative Healthy Smart Solar Nanobiotechnology ™ © (Osler, 2021) designed to biobalance a non-ionized irradiated environment. The in-depth mathematics mentioned in this paper are the foundational elements for groundbreaking innovative terminologies and new pioneering scientific fields covered in detail to explicitly explain how Healthy Smart Solar Nanobiotechnology ™ © interacts with and works within the environment. These revolutionary fields of study are directly associated with the mitigating mathematical operation of Solar Smart Nanobiotechnology ™ ©. The mathematics defined in the paper also aid in the creation of new, novel, and original areas and arenas of knowledge that are designed to most accurately describe the trichotomous holistic solutions that can be used to create an all around healthy and safe environment for the well-being of all.
The Impact of Transformational Leadership Factors on Public Service Innovation Outcomes: An Evidence from Bangladesh
Authors: Shumshunnahar Mst.
Published: October 2021

The aim of this research is to examine the effect of the factors of Transformational leadership on public service innovation outcomes. Survey data collected from 500 innovation officers of field level administration of Bangladesh. Results from the multiple regression analysis using SPSS indicated that there was a positive impact of Idealized Influence, Inspirational Motivation, Intellectual Stimulation and Individualized Consideration on public service innovation outcomes. The finding also implies that the policy makers should build a strong strategy to put more concentration and heighten transformational leadership to enhance public service innovation outcomes.
Household Waste Management in Cameroon: The Case of Bamenda and Buea Municipalities
Authors: Forje Lema Catherine
Published: October 2021

Urban sanitation and hazard risk reduction strategies that aim to maintain a clean and healthy society will only be successful and sustainable if it includes educating and training the people on how to handle their household waste.  Nations and organisations must innovate in order to sustain the health of population growth and other global demands.  It is not easy to obtain a complete assessment of risk involve in any undertaking.  The problem is even more in an innovative project like the case of hysacam waste disposal in Buea and Bamenda in Cameroon. What distinguishes standard processes from innovation is their level of uncertainty.  Therefore, ways of assessing and addressing the magnitude of risks involve must come high on the list of techniques for managing innovations.  The risk surrounding garbage disposal in Cameroon is a course for concern. The objective of this paper is to present and discuss the assumptions which underlie the key frame of reference used to understand waste disposal in order to make garbage disposal using the new system risk free and sustainable.  The study focuses on household’s waste disposal in Bamenda and Buea towns in Cameroon. According to prior studies in this area, (Jake Ansell & Frank Wharton 1992; Keith Goffin & Rick Mitchell 2005) risk is an unavoidable feature of human existence. Neither man nor organisations/societies can survive for long without taking risks.  Mark and Eve (2006) suggest that people be advised to separate organic waste from solid waste before depositing for collection to a compositing depot. Data was gathered through face to face interview with those disposing garbage and the population concern. In all, 150 people were interviewed, 5 employees holding executive posts, 35 workers involve in the day to day carrying of garbage, 100 service users in the town of Buea and Bamenda where the service is being delivered and 10 people, both service delivers and service users in Douala (Cameroon) where such a service started and has since been operating for long (since the 1960s) were interviewed.  Data is analysed both qualitative and quantitative.  Result suggests that while the innovative garbage disposal technique is good as it is quick and cover large areas, keeps the city clean for healthy living, it is an innovative action therefore, both the service providers and users need to be trained (educated) to make the service worthwhile and sustainable. Education will empower people with appropriate knowledge on how to handle garbage with care. The implications would be: reduced risk of bacterial spread in streets, reduced ardour, clean air and quality well being greatly improved.  The validity of the study lies in its ability to spread information that can improve the operation system of garbage disposal, making the service attain its objective of keeping a city clean and promote healthy living.
Constitutional and Legal Issues in Ghana’s Public Administration: Governance and Public Policy Challenges
Authors: Fobih Nick
Published: October 2021

The purpose of this study is to examine some of the major constitutional and legal issues that are imperative in Ghana’s public administration. Despite Ghana’s success in promoting democratic governance over the past decades since the 1992 transition, numerous constitutional and legal issues affect effective policy design and implementation that require urgent governmental reforms. The study discussed the constitutional and democratic theories as the basis of the work. The methodology used is based on the qualitative approach with combined sources from primary and secondary data. The findings in the study show that certain aspects of Ghana’s constitutional provisions and legal framework do adversely affect its policy design and implementation in diverse ways. The significance of the study is that the outlined challenges and recommendations will inform the government and key policy makers on the need to make effective policies in order to enhance the country’s political and socio-economic development. The study’s implication for theory is that it will inform its readers about the different theoretical perspectives on the issues discussed. The study also provides key insights into important issues in Ghana’s constitutional provisions, and the legal and policy environment, which can serve as useful tools or instruments for policy makers in the three organs of government and the bureaucracy. This study further contributes towards academic discussions on the viability of the constitutions drawn by authoritarian regimes prior to the third-wave democratic transitions in Africa, and the difficulties some of these constitutional provisions pose to making effective policies and governance, thus emphasizing the need for constitutional reviews.
Review and evolution of guidelines for diagnosis of COVID-19 vaccine induced thrombotic thrombocytopenia (VITT)
Authors: Favaloro Emmanuel J. , Pasalic Leonardo , Lippi Giuseppe
Published: October 2021

Coronavirus disease 2019 (COVID-19) is a life-threatening infectious disease caused by Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2). In response to the still ongoing pandemic outbreak, a number of COVID-19 vaccines have been quickly developed and deployed. Although minor adverse events, either local (e.g., soreness, itch, redness) or systematic (fever, malaise, headache, etc.), are not uncommon following any COVID-19 vaccination, one rare vaccine-associated event can cause fatal consequences due to development of antibodies against platelet factor 4 (PF4), which trigger platelet activation, aggregation, and possible resultant thrombosis, often at unusual vascular sites. Termed thrombosis with thrombocytopenia syndrome (TTS) by reporting government agencies, the term vaccine-induced (immune) thrombotic thrombocytopenia (VITT) is more widely adopted by workers in the field. In response to increasing reports of VITT, several expert groups have formulated guidelines for diagnosis and/or management of VITT. Herein, we review some key guidelines related to diagnosis of VITT, and also provide some commentary on their development and evolution.
How to Project a Socially Constructed Sexual Orientation
Authors: Finocchiaro Peter
Published: October 2021

Was bisexuality a widespread feature of ancient Greek society? This question is an instance of cross-cultural projection -- of taking the means through which people are categorized in one culture and applying it to members of another. It’s widely held by those who think that sexual orientation is socially constructed that its projection poses a problem. In this paper, I offer a more careful analysis of this alleged problem. To analyze projection, I adapt Iris Einheuser’s substratum-carving model of conventionalism to fit the specific needs of social construction (and social metaphysics more broadly). Using this model, I show that projection is conceptually coherent, and so does not for that reason pose any problem. Along the way, I identify some of the epistemic difficulties facing projection. While these difficulties are formidable, they are not substantially affected by the constructivist claim. I therefore conclude that there is no unique problem facing the projection of a socially constructed sexual orientation.
Activation cross sections of some neutron-induced reactions in the energy range of 13.82–14.71 MeV
Authors: Uddin Md Shuza
Published: October 2021

The cross sections of the reactions 70Zn(n,2n)69mZn,74Ge(n,α)71mZn and 90Zr(n,2n)89m,gZr in the energy range of 13.82–14.71 MeV were measured by the activation technique in combination with HPGe detector γ-ray spectroscopy. The measured results were compared with other experimental data and with the data given in the library TENDL-2019. A nuclear model calculation based on the code TALYS-1.8 was also performed after adjustment of an input parameter for the spin distribution of level density. The results of this work strengthen the database and could be useful in further evaluation of the data.
Cold Stress Induced a Higher Level of Fat Oxidation in Women
Authors: Niu Xinting , Han Peng , Tang Zujie , Huang Jin , Li Li , He Hui , Zhang Wenzhong , Zhao Li , Zhao Lei
Published: October 2021

Niu, X, Han, P, Tang, Z, Huang, J, Li, L, He, H, Zhang, W, Zhao, L, and Zhao, L. Cold stress induced a higher level of fat oxidation in women. J Strength Cond Res 37(1): 114–122, 2023—To investigate women's fat oxidation under cold stress during incremental exercise testing and compare the effect of cold stress on fat oxidation between the sexes. Twenty-six healthy subjects performed 2 incremental exercise tests to determine maximal oxygen uptake (V̇o
2max) on a treadmill in different ambient temperatures. Cardiopulmonary variables were continuously recorded during incremental exercise tests. Maximal fat oxidation (MFO) and the corresponding exercise intensity (Fatmax) were determined from the fat oxidation curve constructed by indirect calorimetry. Both men and women relied more on fat oxidation in cold environment (p < 0.05). Compared with men, fat oxidation was significantly greater in women in the cold environment from 50 to 70% V̇o
2max (p < 0.05). There were no significant differences in the change of fat oxidation as exercise intensity increased between the sexes (p > 0.05). Women had a greater MFO (p < 0.05) and Fatmax (p < 0.05) than men in the cold environment. When MFO was the dependent variable, sex, fat-free mass, fat mass, V̇o
2max, and temperature accounted for 48% of its variability. We conclude that cold stress enhances fat oxidation in women. Compared with men, women have significantly higher value and rely more on fat oxidation to supply energy in the cold environment, although the increasing level of fat oxidation was similar between the sexes. These factors may have important implications in the individualization of exercise prescription in cold conditions for both men and women.
Health Screening and Updated Blood Pressure Guidelines and Their Application for the Certified Personal Trainer
Authors: Young Jeff
Published: October 2021

Certified National Strength and Conditioning Association personal trainers are “health/fitness professionals who, using an individualized approach, assess, motivate, educate, and train clients regarding their health and fitness needs. They design safe and effective exercise programs, provide the guidance to help clients achieve their personal health/fitness goals, and respond appropriately in emergency situations. Recognizing their area of expertise, personal trainers refer clients to other health care professionals when appropriate.” The design of safe and effective exercise programs includes the need to stay current with published research and changes to relevant exercise guidelines. The purpose of this article is to provide a brief overview of recent changes to the exercise preparticipation health screen, application of the physical activity readiness questionnaire for everyone (PAR-Q+), updated blood pressure guidelines, and recommendations for program design given these changes.
The Materiality of Monetary Value in Martial’s Epigrams
Authors: Piros Elliott
Published: October 2021

This paper examines representations of money in the epigrams of Martial. I argue that Martial’s poetics are deeply influenced by some of money’s economic functions, even if many of these functions are approached through networks of amicitia. By engaging with the indeterminacy of what can be called exchange value, Martial identifies an aesthetic dimension that becomes central to his humor. The form of value described by his paradoxical poetics of cash implies a category of matter that is at once sensuous and abstract, autonomous and dependent upon other modes of valuation. I focus on the sensuality of this abstract matter, its failure to become entirely impersonal, and on Martial’s habit of using deictic language to gesture to its presence. Such an aestheticization of monetary value differs from more familiar techniques of using vivid language to flesh out moral or satirical attitudes to wealth or the ways in which it is acquired. It instead approaches the instability of money as an object of inspiration in its own right, one that supports the epigrammatist’s habit of taking up postures throughout his corpus of poems, and of maintaining a degree of detachment between his voice and its pronouncements.
Handel’s Transformative Compositional Practices
Authors: Hurley David Ross
Published: October 2021

In recent decades singers of Handel’s music have made great strides in recapturing the art of embellishing his music, thus breathing new life into forms such as the da capo aria. Yet Handel’s own “variations”—his development and transformation of musical material in his vocal music, important for understanding his compositional practice with borrowed as well as (presumably) original music—are not yet fully explored or appreciated. Admittedly, scholars have discussed musical procedures such as inserting, deleting, and reordering musical materials, as well as other Baroque combinatorial practices in Handel’s arias, but the musical transformations I discuss here are closer to a specifically Handelian brand of developing variation. To my knowledge, the concept of developing variation has never before been applied to early eighteenth-century music. I explore the relation of developing variation to drama (also rarely done) in two of Handel’s arias, providing a close examination of “Ombre, piante” from the opera Rodelinda and new thoughts about “Lament not thus,” originally intended for the oratorio Belshazzar. Although these arias belong to different genres and different stages of Handel’s career, they both exhibit material that undergoes a kind of progressive variation process that has tangible musical and dramatic ramifications, of interest to opera specialists and performers. Furthermore, both arias have a complicated compositional history; I offer fresh insights into the aesthetic qualities of each version, thereby throwing light on Handel’s possible compositional intentions. This article also discloses for the first time some recurring musical passages shared between “Lament not thus” and other pieces that could influence the listener’s interpretation of certain musico-dramatic gestures.
“Come brother Opie!”
Authors: Bray Joe
Published: October 2021

Joe Bray, “‘Come brother Opie!’: Amelia Opie and the Courtroom” (pp. 137–162)

This essay examines how Amelia Opie’s lifelong fascination with the human drama of the courtroom is reflected in her fiction, specifically in her tales that revolve around trial scenes. Focusing on three examples in particular, “Henry Woodville” (1818), “The Robber” (1806), and “The Mysterious Stranger” (1813), it argues that Opie’s fictional courtrooms encourage an emotional engagement on the part of both characters and narrators, which in turn can be extended to that of the reader. In the case of “The Mysterious Stranger,” a character is on figurative trial throughout, with both narrator and reader frequently in the dark as to her motives. As a result, judgment is both hazardous and uncertain. Through a sympathetic representation of the passions and vicissitudes experienced by all those in the courtroom context, whether real or metaphorical, Opie’s fiction develops a model of readerly participation that adds a new, affective dimension to traditional accounts of the relationship between early-nineteenth-century literature and the law.
An integrated approach to the formation of mathematical and natural science literacy of middle school students
Authors:   Novosibirsk State Pedagogical University, Yarovaya Yevgeniya Anatolyevna
Published: October 2021

The purpose of the article is to describe the author’s comprehensive approach to the formation of mathematical and natural science literacy of middle school students by performing complex tasks with biological content using scientific and methodological foundations and relying on his own experience. The article substantiates the relevance of research in this direction and formulates a contradiction that leads to the problem of finding optimal approaches to the formation of mathematical and natural science literacy of schoolchildren as components of functional literacy. The author offers an integrated approach to the formation of the two components of functional literacy in teaching mathematics in primary school, which correlates with the formation of meta-subject results in accordance with the requirements of the Federal State Educational Standard. Complex tasks with biological content are selected as a means of forming mathematical and natural science literacy, methodological requirements for their compilation are described and examples of tasks are demonstrated. According to the results of the study, conclusions are formulated. The prospects of work in the direction of using complex tasks with scientific content for the formation of functional literacy of students of specialized classes are outlined.
Broad-spectrum XX and XY gonadal dysgenesis in patients with a homozygous L193S variant in PPP2R3C
Authors: Cicek Dilek , Warr Nick , Yesil Gozde , Kocak Eker Hatice , Bas Firdevs , Poyrazoglu Sukran , Darendeliler Feyza , Direk Gul , Hatipoglu Nihal , Eltan Mehmet , Yavas Abali Zehra , Gurpinar Tosun Busra , Kaygusuz Sare Betul , Seven Menevse Tuba , Helvacioglu Didem , Turan Serap , Bereket Abdullah , Reeves Richard , Simon Michelle , Mackenzie Matthew , Teboul Lydia , Greenfield Andy , Guran Tulay
Published: October 2021

Context

Homozygous and heterozygous variants in PPP2R3C are associated with syndromic 46,XY complete gonadal dysgenesis (Myo-Ectodermo-Gonadal Dysgenesis (MEGD) syndrome), and impaired spermatogenesis, respectively. This study expands the role of PPP2R3C in the aetiology of gonadal dysgenesis (GD).

Method

We sequenced the PPP2R3C gene in four new patients from three unrelated families. The clinical, laboratory, and molecular characteristics were investigated. We have also determined the requirement for Ppp2r3c in mice (C57BL6/N) using CRISPR/Cas9 genome editing.

Results

A homozygous c.578T>C (p.L193S) PPP2R3C variant was identified in one 46,XX girl with primary gonadal insufficiency, two girls with 46,XY complete GD, and one undervirilised boy with 46,XY partial GD. The patients with complete GD had low gonadal and adrenal androgens, low anti-Müllerian hormone, and high follicle-stimulating hormone and luteinizing hormone concentrations. All patients manifested characteristic features of MEGD syndrome. Heterozygous Ppp2r3c knockout mice appeared overtly normal and fertile. Inspection of homozygous embryos at 14.5, 9.5, and 8.5 days post coitum(dpc) revealed evidence of dead embryos. We conclude that loss of function of Ppp2r3c is not compatible with viability in mice and results in embryonic death from 7.5 dpc or earlier.

Conclusion

Our data indicate the essential roles for PPP2R3C in mouse and human development. Germline homozygous variants in human PPP2R3C are associated with distinctive syndromic GD of varying severity in both 46,XY and 46,XX individuals.
La educación media como espacio de disputa La deconstrucción del discurso sobre la sexualidad en Costa Rica, 1960-2018
Authors: Campos-Monge Hermes
Published: October 2021

En 1985 se elaboraron textos denominados guías sexuales, cuyo fin era brindar un material de apoyo para el desarrollo de las lecciones de afectividad y sexualidad en las escuelas secundarias de Costa Rica. Desde entonces, una fuerte oposición a un material nuevo, más científico e inclusivo despertó una polémica de años entre grupos conservadores y religiosos y la necesidad de brindar un programa de formación a las juventudes que fuera más real. Este artículo plantea que los programas de educación para la sexualidad han sido objeto constante de críticas y discusiones de origen ideológico, que han llevado a la educación media costarricense a convertirse en un espacio de disputa; donde la representación adultocentrista ha atravesado el discurso sobre  exualidad/sexualidades y ha dejado de lado la opinión del sector más importante: el estudiantado adolescente.
Ausencia del padre y orfandad masculina: Notas Sobre Pedro Páramo
Authors: García-Rey Rocío
Published: October 2021

Pedro Páramo es una novela fundamental de la literatura contemporánea en el ámbito hispanoamericano.  El inicio de la novela proporciona la clave del periplo del hijo abandonado que va a buscar al padre ausente; el hombre cuya única claridad es su ausencia, su abandono. Es una búsqueda transformada en historia de un duelo no resuelto, un dolor que el hijo acumulará sin entender que la ausencia del padre es la presencia de la misma muerte.  Me centraré en el ejercicio de interpretar la obra literaria desde le creación y recreación del lenguaje y de los temas, para seguir escudriñando “rutas de interpretación” en el sentido propuesto por Wolfgang Iser. El comentario con respecto al tema de Pedro Páramo lo haré en clave de los estudios de género, particularmente de aquellos planteamientos de la estudiosa chilena, Sonia Montesinos
“El sur también existe”
Authors: Romero-Reyes Andrea
Published: October 2021

La crítica latinoamericana tiene que interpelar nuestra realidad, de colonialismos e imperialismos sucesivos, avasallantes, y solo así, vincularnos a nuestrahistoria real, para poder juntos y “entre todos” generar esas condiciones que nos permitan transformarla, que sin lugar a duda, muchos y muchas ya hancomenzado a hacer. Se trata de plantear ese punto de vista latinoamericano, de reivindicarlo, de desglosarlo, para reconstruirlo con nuevos sentidos.
MEDIA MYTHS ABOUT KALEVALA AND REALITY: A CULTURAL APPROACH
Authors: Suvorova IRINA
Published: October 2021

The article deals with the problem of the truth of modern media myths using specific information materials about Kalevala, the homeland of classical Karelian mythology. The study was conducted in two stages: the empirical stage was carried out during a comprehensive research expedition of the Humanitarian Innovation Park of Petrozavodsk State University to the Kalevala National District of Karelia, while the second stage was implemented during the office processing of the collected data. Sociological survey and in-depth interview, as well as the analysis and comparison of media myths and classical myths were used as research methods. The second stage of the study led to some generalizations and conclusions. As a result of the study, essential functions performed by media myths in modern culture were identified; six media myths about Kalevala were verified; each myth’s content and its reflection in reality were analyzed. Special attention was paid to the transformation of the classical Karelian myth of Sampo into a modern media myth verified in this study. All in all, the article presents conclusions about the conformity of modern media myths with the provisions of Aleksey Losev’s mythological theory and summarizes the cultural and creative function of modern media mythology.