bluuebunny/crossref_metadata_2025 huggingface dataset:
IL12/23 Blockade with Ustekinumab as a Treatment for Immune-Related Cutaneous Adverse Events
Authors: Gu Stephanie L. , Maier Tara , Moy Andrea P. , Dusza Stephen , Faleck David M. , Shah Neil J. , Lacouture Mario E.
Published: November 2023

Background: Immune-related cutaneous adverse events (ircAEs) are frequent and may reduce quality of life and consistent dosing. IL12/23 has been implicated in psoriasis, which is reminiscent of the psoriasiform/lichenoid ircAE phenotype. We report the use of ustekinumab as a therapeutic option. Methods: Patients at Memorial Sloan Kettering Cancer Center, New York, who received immune checkpoint inhibitors and were treated with ustekinumab or had the keywords “ustekinumab” or “Stelara” in their clinical notes between 1 March 2017 and 1 December 2022 were retrospectively identified via a database query. Documentation from initial and follow-up visits was manually reviewed, and response to ustekinumab was categorized into complete cutaneous response (CcR, decrease to CTCAE grade 0), partial cutaneous response (PcR, any decrease in CTCAE grade exclusive of decrease to grade 0), and no cutaneous response (NcR, no change in CTCAE grade or worsening). Labs including complete blood count (CBC), cytokine panels, and IgE were obtained in a subset of patients as standard of care. Skin biopsies were reviewed by a dermatopathologist. Results: Fourteen patients with psoriasiform (85.7%), maculopapular (7.1%), and pyoderma gangrenosum (7.1%) ircAEs were identified. Ten (71.4%) receiving ustekinumab had a positive response to treatment. Among these 10 responders, 4 (40%) demonstrated partial cutaneous response and 6 (60%) demonstrated complete cutaneous resolution. Six patients (42.9%) experienced interruptions to their checkpoint inhibitor treatment as a result of intolerable ircAEs, and following ircAE management with ustekinumab, two (33.3%) were successfully rechallenged with their checkpoint inhibitors. On histopathology, patients primarily had findings of interface or psoriasiform dermatitis. No patients reported an adverse event related to ustekinumab. Conclusions: Ustekinumab showed a benefit in a subset of patients with psoriasiform/lichenoid ircAEs. No safety signals were identified. However, further prospective randomized controlled trials are needed to confirm our findings.
Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study
Authors: Safhi Awaji Y. , Siddique Waqar , Zaman Muhammad , Sarfraz Rai Muhammad , Shafeeq Ur Rahman Muhammad , Mahmood Asif , Salawi Ahmad , Sabei Fahad Y. , Alsalhi Abdullah , Zoghebi Khalid
Published: November 2023

A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric buccal films of Eletriptan Hydrobromide (EHBR) and Itopride Hydrochloride (ITHC) to improve their bioavailability and, hence, improve compliance with the patients of migraines and its associated symptoms. The prepared films were evaluated for various in vitro parameters, including surface morphology, mechanical strength, disintegration test (DT), total dissolving time (TDT), drug release and drug permeation, etc., and in vivo pharmacokinetic parameters, such as area under curve (AUC), mean residence time (MRT), half-life (t1/2), time to reach maximum concentration (Tmax), and time to reach maximum concentration (Cmax). The outcomes have indicated the successful preparation of the films, as SEM has confirmed the smooth surface and uniform distribution of drugs throughout the polymer matrix. The films were found to be mechanically stable as indicated by folding endurance studies. Furthermore, the optimized formulations showed a DT of 13 ± 1 s and TDT of 42.6 ± 0.75 s, indicating prompt disintegration as well as the dissolution of the films. Albino rabbits were used for in vivo pharmacokinetics, and the outcomes were evident of improved pharmacokinetics. The drug was found to rapidly permeate across the buccal mucosa, leading to increased bioavailability of the drug: Cmax of 130 and 119 ng/mL of ITHC and EHBR, respectively, as compared to 96 (ITHC) and 90 ng/mL (EHBR) of oral solution. The conclusion can be drawn that possible reasons for the enhanced bioavailability could be the increased surface area in the form of buccal films, its rapid disintegration, and faster dissolution, which led toward the rapid absorption of the drug into the blood stream.
Preliminary Comparisons of Tender Shoots and Young Leaves of 12 Mulberry Varieties as Vegetables and Constituents Relevant for Their Potential Use as Functional Food for Blood Sugar Control
Authors: Wei Jia , Zhu Yan , Lin Tianbao , Tao Han , Chen Lei , Xu Zilong , Lv Zhiqiang , Liu Peigang
Published: November 2023

Vegetables are essential for maintaining health and preventing diseases due to their nutrients and functional components. However, vegetables specifically designed for blood sugar control are limited. The mulberry tree (Morus) offers potential as a source of functional vegetables with blood-sugar-lowering properties, mainly attributed to 1-Deoxynojirimycin (DNJ). This study compared the nutritional composition and DNJ content in various edible parts of twelve mulberry tree varieties. Sensory evaluations were also conducted to assess sensory attributes. Interestingly, DNJ was found to show a positive correlation with sensory evaluations. Furthermore, the sugar content, particularly sucrose, was significantly higher in tender shoots than leaves, indicating tender shoots as a preferable choice for development as a functional food for blood sugar control. Finally, VM 19 and VM 22 are considered as good candidates for the mulberry vegetable using varieties after sensory evaluation and combining with the DNJ content. These findings provide valuable insights for future research into vegetable selections for blood sugar management and support the potential commercialization of mulberry leaf vegetables as functional food options.
Evaluation of the Harvest Dates for Three Major Cultivars of Blue Honeysuckle (Lonicera caerulea L.) in China
Authors: Yu Min , Li Songlin , Zhan Ying , Huang Zhiqiang , Lv Jinjiao , Liu Yu , Quan Xin , Xiong Jinyu , Qin Dong , Huo Junwei , Zhu Chenqiao
Published: November 2023

Blue honeysuckle (Lonicera caerulea L.) is an emerging fruit crop; however, determining its proper harvest time in commercial cultivation remains challenging due to its rapid fruit development characteristics. In this study, we investigated 17 agronomic traits of three blue honeysuckle cultivars harvested on 5 successive dates within their respective harvest windows. ‘Lanjingling’, ‘Wulan’, and ‘Berel’ showed solid–acid ratios (SS:TA) ranging from 10.00 to 16.01, 8.13 to 10.23, and 5.77 to 7.11, respectively; anthocyanin contents ranged from 233.85 to 276.83 mg/100 g, 236.38 to 312.23 mg/100 g, and 235.71 to 334.98 mg/100 g, respectively; vitamin C contents ranged from 88.43 to 99.68 mg/100 g, 108.13 to 191.23 mg/100 g, and 89.71 to 120.40 mg/100 g, respectively; phenolic contents ranged from 25.22 to 37.59 mg/g, 25.40 to 36.52 mg/g, and 37.66 to 50.00 mg/g, respectively. The results revealed the SS:TA value consistently increased with delayed harvesting and were significantly negatively correlated with fruit firmness, total acidity, shelf life, and respiration intensity, suggesting it is an ideal maturity indicator for blue honeysuckle berries. The factor analysis suggests that the suitable harvest date for ‘Lanjingling’ could be either 47 days after flowering (DAF) with an SS:TA value of approximately 10.0, characterized by high firmness, extended shelf life, and elevated levels of anthocyanins and phenolics; or 67 DAF (SS:TA ≈ 16.0), characterized by high vitamin C content and sweetness, and larger size and weight. For ‘Wulan’, it suggests the suitable harvest date is either 54 DAF (SS:TA ≈ 9.0), yielding fruit with high levels of anthocyanins and vitamin C; or 62 DAF (SS:TA > 10.0), yielding fruit with high sweetness and large size and weight. For ‘Berel’, it is suggested to be either 52 DAF (SS:TA ≈ 6.5), resulting in fruit with high levels of anthocyanins and vitamin C; or 62 DAF (SS:TA > 7.0), resulting in balanced levels of the fruit quality traits.
Mechanism of PVDF Membrane Formation by NIPS Revisited: Effect of Precipitation Bath Nature and Polymer–Solvent Affinity
Authors: Basko Andrey , Lebedeva Tatyana , Yurov Mikhail , Ilyasova Anna , Elyashevich Galina , Lavrentyev Viktor , Kalmykov Denis , Volkov Alexey , Pochivalov Konstantin
Published: November 2023

A new interpretation of the mechanism of the polyvinylidene fluoride (PVDF) membrane formation using the nonsolvent-induced phase separation (NIPS) method based on an analysis of the complete experimental phase diagram for the three-component mixture PVDF–dimethyl acetamide (DMAc)–water is proposed. The effects of the precipitation bath’s harshness and thermodynamic affinity of the polymer’s solvent on the morphology, crystalline structure, transport and physical–mechanical properties of the membranes are investigated. These characteristics were studied via scanning electron microscopy, wide-angle X-ray scattering, liquid–liquid porosimetry and standard methods of physico-mechanical analysis. It is established that an increase in DMAc concentration in the precipitation bath results in the growth of mean pore size from ~60 to ~150 nm and an increase in permeance from ~2.8 to ~8 L m−2 h−1 bar−1. It was observed that pore size transformations are accompanied by changes in the tensile strength of membranes from ~9 to ~11 and to 6 MPa, which were explained by the degeneration of finger-like pores and appearance of spherulitic structures in the samples. The addition of water to the dope solution decreased both the transport (mean pore size changed from ~55 to ~25 nm and permeance reduced from ~2.8 to ~0.5 L m−2 h−1 bar−1) and mechanical properties of the membranes (tensile strength decreased from ~9 to ~6 MPa). It is possible to conclude that the best membrane quality may be reached using pure DMAc as a solvent and a precipitation bath containing 10–30% wt. of DMAc, in addition to water.
The Challenges Facing the Current Paradigm Describing Viscoelastic Interactions in Polymer Melts
Authors: Ibar Jean Pierre
Published: November 2023

Staudinger taught us that macromolecules were made up of covalently bonded monomer repeat units chaining up as polymer chains. This paradigm is not challenged in this paper. The main question raised in polymer physics remains: how do these long chains interact and move as a group when submitted to shear deformation at high temperature when they are viscous liquids? The current consensus is that we need to distinguish two cases: the deformation of “un-entangled chains” for macromolecules with molecular weight, M, smaller than Me, “the entanglement molecular weight”, and the deformation of “entangled” chains for M > Me. The current paradigm stipulates that the properties of polymers derive from the statistical characteristics of the macromolecule itself, the designated statistical system that defines the thermodynamic state of the polymer. The current paradigm claims that the viscoelasticity of un-entangled melts is well described by the Rouse model and that the entanglement issues raised when M > Me, are well understood by the reptation model introduced by de Gennes and colleagues. Both models can be classified in the category of “chain dynamics statistics”. In this paper, we examine in detail the failures and the current challenges facing the current paradigm of polymer rheology: the Rouse model for un-entangled melts, the reptation model for entangled melts, the time–temperature superposition principle, the strain-induced time dependence of viscosity, shear-refinement and sustained-orientation. The basic failure of the current paradigm and its inherent inability to fully describe the experimental reality is documented in this paper. In the discussion and conclusion sections of the paper, we suggest that a different solution to explain the viscoelasticity of polymer chains and of their “entanglement” is needed. This requires a change in paradigm to describe the dynamics of the interactions within the chains and across the chains. A brief description of our currently proposed open dissipative statistical approach, “the Grain-Field Statistics”, is presented.
Configurations of Care Work: Fragile Partnerships in the Co-Production of Long-Term Care Services
Authors: Tingvold Laila , Olsvold Nina
Published: November 2023

Over the last decade, authorities in several Western countries have stated their ambitions to increase the share of volunteers contributing alongside professionals in the future long-term care (LTC) sector, but the introduction of volunteers as co-producers of care services is sparsely investigated. This article is based on an empirical case study in Norway and investigates how co-production is translated into practice in diverse settings. Our findings demonstrate that understandings of voluntary work were fragmented. Co-production appears as a fragile partnership with an unclear understanding of the roles, expectations, and opportunities among the various parties who had different purposes/agendas and limited knowledge. To successfully provide added value in coproducing care, agents need to understand the whole picture and context, and build a common understanding of ‘why’ coproduce.
Nature and Belonging in the Lives of Young Refugees: A Relational Wellbeing Perspective
Authors: Haswell Nick
Published: November 2023

This paper explores the relationship between nature contact, wellbeing and belonging in the resettlement experiences of young refugees in Finland. Drawing on qualitative data, including participant-made artworks and semi-structured interviews, it explores the different ways refugees encounter nature in their past, present and (imagined) future. Using a relational wellbeing approach, the paper considers how subjective, material and relational dimensions of wellbeing arise and interrelate within refugees’ encounters with nature and how these encounters link with refugees’ developing sense of belonging to people and places in Finland. The paper describes how, in the context of refugee resettlement, nature encounters can foster a sense of belonging in three ways: through restoration and attachment in the present, through maintaining links with the past, and through shaping desires about a future in which to thrive. Considering refugees’ sense of belonging in Finland as part of the relational wellbeing generated, in part, from their encounters with nature, these three aspects of belonging represent particular interrelations between subjective, material and relational dimensions of refugees’ wellbeing.
Performance of the Flexible and Rigid Lining under Earthquake Impact and Weakness of the New Austrian Tunneling Method (NATM) Principles, a Specific Case Study of the Bolu Tunnel
Authors: Aygar Ebu Bekir
Published: November 2023

The Bolu tunnel is located between the Istanbul-Ankara Highway and its construction took approximately 13 years. Since the beginning of the tunnel excavation, serious deformations and stability problems have been encountered. The basis of the problems encountered during the tunnel excavation is the fact that the geological units through which the tunnel passes are very weak and fault lines cut the tunnel location. The fault lines pass through secondary faults in the seismically active North Anatolian Fault. At these fault crossings, deformations occurred continuously so that revisions had to be made in the support systems. The 12 November 1999 Düzce earthquake occurred on the Düzce fault and a surface rupture 40 km long was caused. The rupture terminated 1.5 km west of the tunnel; it did not reach the tunnel. Throughout the earthquake, instances of collapse occurred at the areas excavated on the fault line at the entrance of Elmalık and where the deformations exceeded 1.0 m; this section of the tunnel had to be abandoned. After these problems, a new improved design for tunnel excavation was developed. These new support systems, which are Bernold lining and bench pilot tunnel systems, contain allowance for rigid lining that is the opposite of the new Austrian tunneling method (NATM) principles. Within the scope of this study, the causes of the collapse in the tunnel are investigated and the effect of the Düzce earthquake on the tunnel is discussed. Also, the applicability of the NATM in tunnels excavated on weak zones is also discussed.
Estimation of Crops Future Irrigation Water Needs in a Mediterranean Plain
Authors: Papanastasiou Dimitris K. , Keppas Stavros , Melas Dimitris , Katsoulas Nikolaos
Published: November 2023

Agriculture is a vulnerable sector to climate change due to its sensitivity to weather conditions. Changes in climatic parameters such as temperature and precipitation significantly affect productivity as well as the consumption of natural resources like water to meet irrigation water needs. There has been a large amount of research on regional climate change. However, this study placed specific crops at first place and considered their irrigation water needs that will arise due to evapotranspiration increase. The aim of this study was to estimate the future irrigation water needs of wheat, cotton, and alfalfa in the east part of Thessaly Plain in central Greece, where Lake Karla, a recently restored lake, is located. The Weather Research and Forecasting (WRF) model was applied as a high-resolution regional climate model to simulate temperature and precipitation for two 5-year periods, namely 2046–2050 (future period) and 2006–2010 (reference period). Simulations refer to the RCP8.5 emission scenario (worst-case). A methodology proposed by the Food and Agriculture Organization (FAO) of the United Nations was followed to estimate the reference crop evapotranspiration, the crop evapotranspiration based on each crop factor, which was determined for each crop, the effective rainfall, and finally, the irrigation water needs for each crop, for the two 5-year periods. Based on WRF simulations, temperature was projected to be 1.1 °C higher in the future period compared to the reference period, while precipitation and effective precipitation were projected to decrease by 32% and 45%, respectively. Based on the WRF projections, by 2025, the irrigation water needs of wheat and alfalfa are expected to increase by more than 16% and more than 11%, respectively, while irrigation water needs of cotton are expected to increase by 7%. An extension of wheat’s irrigation period for one month (i.e., December) was also identified. Good practices that could be applied in the frame of precision agriculture principles in order to save irrigation water were suggested. The results of this study could be exploited by water resources and land use managers when planning short and long-term strategies to adapt to climate change impacts.
A Methodological Approach for Data Collection and Geospatial Information of Healthy Public Spaces in Peripheral Neighborhoods—Case Studies: La Bota and Toctiuco, Quito, Ecuador
Authors: Medina Ana , Mosquera Diana , Gallegos Francisco Alejandro
Published: November 2023

Adequate public spaces and urban green areas are key criteria for urban development and infrastructure implementation in healthy cities. Latterly, there have been an increasing number of research methods using artificial intelligence (AI) to monitor, quantify, and control the state of these spaces with an aim toward pioneering research in urban studies. However, in informal areas, open-data access tends to lack adequate and updated information, making it difficult to use AI methods. Hence, we propose a methodology for restricted open data collection and preparation for future use in machine learning or spatial data science models for similar areas. To that extent, we examine two peripheral and low-income neighborhoods in Quito, Ecuador—La Bota and Toctiuco—to analyze their public spaces, urban green areas, points of interest, and road networks, and how they address healthy cities criteria. We develop an original methodological approach that combines an index of proximity, accessibility, quantity, and quality for these spaces with geospatial and network analysis techniques. Results indicate that the connectivity and structure of these spaces are centralized and nodal, representing exclusion and segregation. This work provides insights into potential healthy spaces and information to urban planners and policymakers in decision-making for healthy urban infrastructure.
A Contribution to Increasing Efficiency in the Water Utility Sector—A Case Study in Kosovo
Authors: Lajqi Shpetim , Ðurin Bojan , Vataj Gjelosh , Nakic Domagoj
Published: November 2023

Due to the rise in energy and water consumption, especially via water losses in water supply systems, it is imperative to reduce and eliminate such problems. Nowadays, commercial efficiency problems are present throughout the world, but in countries with a lower level of development, they have a considerable presence. Therefore, Kosovo, as such a country, has serious problems regarding commercial efficiency in the water sector. Improving performance involves sharing best practices to reduce water losses and improve collection rates. Water losses in Kosovo range from 55 to 61% of water production. Besides water losses, water utilities in Kosovo also have a low collection rate, ranging from 61% to 93% of issued invoices. Alongside these levels of non-revenue water and low collection rates, only 33.55 to 56.73% of produced water generates income. Improvement may be possible through profiling the consumption of large customers, calibrating and installing water meters with high accuracy, reading water materials with handheld devices, improving pressure management, finding illegal connections, selling a proportion of old debts, replacing old pipes with modern materials, etc.
Assessment of Modified Culture Conditions for Fungal Bio-Oxidation of Sulfidic Gold Ores Performed at Circumneutral pH
Authors: Hein Guillermo , Mahandra Harshit , Ghahreman Ahmad
Published: November 2023

The significant neutralization of waste streams required after the acidic bio-oxidation of sulfidic gold ores could be avoided by performing a novel treatment at circumneutral pH with an in situ neutralization. For the first time, the white-rot fungus Phanerochaete chrysosporium was incubated in a modified culture medium containing corn steep, an industrial waste product, to support microbial activity and, subsequently, the oxidation of a sulfidic ore at an initial circumneutral pH environment. In this investigation, the concentration of the native culture medium ingredients was first evaluated with response surface methodology to attain maximum sulfide oxidation. The statistical analysis proposed a modified culture medium composed of 12.86 g/L glucose, 2.20 g/L malt extract, 1.67 g/L yeast extract, and 0.49 g/L MgSO4·7H2O to reach a maximum of 28.7% sulfide oxidation after 14 d-bio-oxidation. pH-controlled batch cultures showed that an increase in initial pH in the range of 5.8 to 7.0 reduced the microbial activity, affecting sulfide oxidation. In addition, the modified culture medium at which yeast extract was substituted with 1.67 g/L corn steep produced comparable microbial activity and sulfide oxidation after 14 d, attaining 21.6% at 5% w/v with a maximum 39 U/L lignin peroxidase and 116 U/L manganese peroxidase. A 40.6% sulfide oxidation and 43.8% gold recovery were obtained after 42 d three-cycle replenishing bio-oxidation and 24 h cyanidation, respectively. Overall, corn steep waste showed the potential to substitute more expensive culture medium ingredients, supporting microbial activity and oxidation of sulfidic gold ores at an initial circumneutral pH and contributing to circularity of waste management.
Pre-Clinical Development of an Adenovirus Vector Based RSV and Shingles Vaccine Candidate
Authors: Petherbridge Lawrence , Davis Charlotte , Robinson Angela , Evans Thomas , Sebastian Sarah
Published: November 2023

Respiratory syncytial virus (RSV) infection and shingles are two viral diseases that affect older adults, and a combined vaccine to protect against both could be beneficial. RSV infection causes hospitalisations and significant morbidity in both children and adults and can be fatal in the elderly. The RSV fusion (F) envelope glycoprotein induces a strong RSV-neutralising antibody response and is the target of protective immunity in the first RSV vaccine for older adults, recently approved by the FDA. An initial childhood infection with the varicella zoster virus (VZV) results in chickenpox disease, but reactivation in older adults can cause shingles. This reactivation in sensory and autonomic neurons is characterized by a skin-blistering rash that can be accompanied by prolonged pain. The approved protein-in-adjuvant shingles vaccine induces VZV glycoprotein E (gE)-fspecific antibody and CD4+ T cell responses and is highly effective. Here we report the evaluation of RSV/shingles combination vaccine candidates based on non-replicating chimpanzee adenovirus (ChAd) vectors. We confirmed the cellular and humoral immunogenicity of the vaccine vectors in mice using T cell and antibody assays. We also carried out an RSV challenge study in cotton rats which demonstrated protective efficacy following a homologous prime-boost regimen with our preferred vaccine candidate.
Performance Evaluation of Five Machine Learning Algorithms for Estimating Reference Evapotranspiration in an Arid Climate
Authors: Raza Ali , Fahmeed Romana , Syed Neyha Rubab , Katipoğlu Okan Mert , Zubair Muhammad , Alshehri Fahad , Elbeltagi Ahmed
Published: November 2023

The Food and Agriculture Organization recommends that the Penman–Monteith Method contains Equation 56 (PMF) as a widely accepted standard for reference evapotranspiration (ETo) calculation. Despite this, the PMF cannot be employed when meteorological variables are constrained; therefore, alternative models for ETo estimation requiring fewer variables must be chosen, which means that they perform at least as well as, if not better than, the PMF in terms of accuracy and efficiency. This study evaluated five machine learning (ML) algorithms to estimate ETo and compared their results with the standardized PMF. For this purpose, ML models were trained using monthly time series climatic data. The created ML models underwent testing to determine ETo under varying meteorological input combinations. The results of ML models were compared to assess their accuracy and validate their performance using several statistical indicators, errors (root-mean-square (RMSE), mean absolute error (MAE)), model efficiency (NSE), and determination coefficient (R2). The process of evaluating ML models involved the utilization of radar charts, Smith graphs, heatmaps, and bullet charts. Based on our findings, satisfactory results have been obtained using RBFFNN based on M12 input combinations (mean temperature (Tmean), mean relative humidity (RHmean), sunshine hours (Sh)) for ETo estimation. The RBFFNN model exhibited the most precise estimation as RMSE obtained values of 0.30 and 0.22 during the training and testing phases, respectively. In addition, during training and testing, the MAE values for this model were recorded as 0.15 and 0.17, respectively. The highest R2 and NSE values were noted as 0.98 and 0.99 for the RBFNN during performance analysis, respectively. The scatter plots and spatial variations of the RBFNN and PMF in the studied region indicated that the RBFNN had the highest efficacy (R2, NSE) and lowest errors (RMSE, MAE) as compared with the other four ML models. Overall, our study highlights the potential of ML models for ETo estimation in the arid region (Jacobabad), providing vital insights for improving water resource management, helping climate change research, and optimizing irrigation scheduling for optimal agricultural water usage in the region.
Assessment of Regression Models for Surface Water Quality Modeling via Remote Sensing of a Water Body in the Mexican Highlands
Authors: Cruz-Retana Alejandro , Becerril-Piña Rocio , Fonseca Carlos Roberto , Gómez-Albores Miguel A. , Gaytán-Aguilar Sandra , Hernández-Téllez Marivel , Mastachi-Loza Carlos Alberto
Published: November 2023

Remote sensing plays a crucial role in modeling surface water quality parameters (WQPs), which aids spatial and temporal variation assessment. However, existing models are often developed independently, leading to uncertainty regarding their applicability. This study focused on two primary objectives. First, it aimed to evaluate different models for chemical oxygen demand (COD), total phosphorus (TP), total nitrogen (TN), and total suspended solids (TSS) in a surface water body, the J. A. Alzate dam, in the Mexican highland region (R2 ≥ 0.78 and RMSE ≤ 16.1 mg/L). The models were estimated using multivariate regressions, with a focus on identifying dilution and dragging effects in inter-annual flow rate estimations, including runoff from precipitation and municipal discharges. Second, the study sought to analyze the potential scope of application for these models in other water bodies by comparing mean WQP values. Several models exhibited similarities, with minimal differences in mean values (ranging from −9.5 to 0.57 mg/L) for TSS, TN, and TP. These findings suggest that certain water bodies may be compatible enough to warrant the exploration of joint modeling in future research endeavors. By addressing these objectives, this research contributes to a better understanding of the suitability of remote sensing-based models for characterizing surface water quality, both within specific locations and across different water bodies.
Quality management in the import and sale of tropical and subtropical fruits
Authors:   Department of Commodity Expert Examination and Customs, Plekhanov Russian University of Economics, Eliseeva L.G. , Tokarev P.I. ,   Department of Commodity Expert Examination and Customs, Plekhanov Russian University of Economics, Rakov N.O. ,   Department of Commodity Expert Examination and Customs, Plekhanov Russian University of Economics, Molodkina P.G. ,   Department of Commodity Expert Examination and Customs, Plekhanov Russian University of Economics, Timofeeva D.S. ,   Department of Commodity Expert Examination and Customs, Plekhanov Russian University of Economics
Published: November 2023

An analysis of the dynamics of the market for fruits imported to Russia has been carried out. The market volume, exporters, and sales volume of tropical fruits in Russia have been studied. The factors shaping the quality of tropical fruits are considered. When ensuring logistics, customs clearance, and storage in distribution centers, it is necessary to take into account the actual degree of maturity of climacteric fruits and manage technological regimes at all stages of product distribution, with regard to the physiological state of the product. The work studies the influence of temperature conditions of storage and ripening of avocado fruits on the duration of storage of fruits and the intensity of the processes responsible for their ripening. The values of respiration intensity and ethylene concentration during storage of avocado fruits, which make it possible to determine the degree of ripeness of the fruit and control the duration of their storage, have been established.
Psychosomatic causes of the gastrointestinal tract functional disorders: historical aspects and modern assessment
Authors:   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Gardanova Zh. R. ,   FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Health of Russia, Esaulov V. I. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Sotnikov V. A. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Kazaryan M. Yu. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Chernov D. N. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Gavisova A. A. ,   FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of the Ministry of Health of Russia, Uporov K. A. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Novikov V. V. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Gardanov A. K. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Ilgov V. I. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Gubaidullin D. Kh. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Nakhapetyan D. A. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Mikirtumova K. A. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Published: November 2023

Psychosomatic disorders are becoming increasingly common among neurotic disorders in the practice of doctors of various profiles. The history of studying psychosomatic disorders goes back to the past, and even in ancient times, doctors paid attention to a special group of diseases, the cause of which was related to the mental state of the patient, while complaints were in the nature of somatic diseases. At the present stage, psychosomatic disorders prevail in the practice of internists, as well as obstetricians and gynecologists. Irritable bowel syndrome, as one of the psychosomatic disorders, currently attracts the attention of many researchers. The article presents the results of a study of pregnant women with irritable bowel syndrome and the peculiarities of their emotional response. The aim of the study was to identify the level of anxiety in pregnant women with IBS, depending on the IBS clinical form. The feeling of anxiety was revealed at an equally high level in all subjects in the experimental and control groups. Tension was more pronounced in the patients with diarrhea predominant irritable bowel syndrome, while depressive states were more often detected in the patients with IBS-D and less pronounced in the subjects with abdominal pain.
Analysis of the quality and content of mycotoxins in feed harvested in the Vologda region
Authors:   North-Western Research Institute of Dairy and Grassland Farming named after A. S. Emelyanova – a separate division of the Federal State Budgetary Institution of Science “Vologda Scientifi c Center of the Russian Academy of Sciences”, Russia, Vologda, Molochnoe, Gusarov I. V. , Obryaeva O. D. ,   North-Western Research Institute of Dairy and Grassland Farming named after A. S. Emelyanova – a separate division of the Federal State Budgetary Institution of Science “Vologda Scientifi c Center of the Russian Academy of Sciences”, Russia, Vologda, Molochnoe
Published: November 2023

Due to the fact that the quality indicators of feed, affecting the quantitative, qualitative indicators of productivity and economic efficiency of dairy farming of agricultural enterprises as a whole underlie the development of a ration system for dairy cows, this determines the relevance of conducting analytical testing of harvested feed. The purpose of the work was to analyze the quality and content of mycotoxins in feed harvested in the Vologda region. The average nutritional value and chemical composition of the best feed harvested in 2022 have been presented. An analysis of the quality and content of mycotoxins in feed was carried out. Samples of the taken feed samples were received for analysis from agricultural enterprises in the Vologda region and were tested in the laboratories of the collective use center of the North-Western Research Institute of Dairy and Grassland Farming named after A. S. Emelyanov. Research has established that for certain parameters characterizing the value of feed, such as the content of neutral detergent and acid detergent fi ber, there are deviations from the recommended values by State National Standard. Data on the content of mycotoxins in feed samples showed a favorable result, which positively characterizes the safety of the harvested feed. Analysis of the quality and content of mycotoxins in feed harvested in the Vologda region in 2021–2022 taking into account ensuring the productivity of the dairy herd in the region indicated the need to improve the feed production systems used in the Vologda region, meeting the requirements of detailed feeding of highly productive dairy cows.
Habilidades linguísticas de crianças usuárias de dispositivos auditivos: revisão narrativa
Authors: Burigo Luana Speck Polli , Woide Luciele Kauana , Santos Thaiana Vargas dos , Paiva Karina Mary , Haas Patricia
Published: November 2023

Objetivo. Avaliar, por meio de uma revisão de literatura, o desenvolvimento das habilidades linguísticas em crianças usuárias de Aparelho de Amplificação Sonora Individual ou Implante Coclear. Método. A busca de artigos científicos foi realizada nas bases de dados MedLine (Pubmed), LILACS, SciELO, Scopus, Web of Science e Bireme, sem restrição de idioma, período e localização. A pesquisa foi conduzida com a recuperação de artigos que respondiam à pergunta norteadora e, em seguida, foram avaliados pelo protocolo de pontuação qualitativa proposto por Pithon et al. (2015). Os artigos elegíveis foram analisados e quantificados de acordo com os critérios propostos, com juízes cegos nas etapas de recuperação. Inicialmente, foram selecionados 64 artigos, posteriormente dimensionados para 7 artigos para a análise final. Resultados. Os estudos indicam que graus maiores de perda auditiva estão associados a níveis linguísticos e de fala mais pobres e a intervenção auditiva é associada ao aumento na qualidade e acessibilidade das representações conceituais e melhora nas habilidades de linguagem oral e escrita. Conclusão. Um programa terapêutico bem estruturado em conjunto com dispositivos de amplificação do som adaptados precocemente e adequadamente de acordo com as necessidades de cada criança, permite o desenvolvimento de forma ampliada e eficiente das habilidades linguísticas narrativas, discursivas, pragmáticas e fonológicas.
Recherches sur divers opisthobranches
Authors: Pelseneer Paul
Published: November 2023

1° Les divers Tectibranches (y compris les Thécosomes et les Gymnosomes) dérivent des Bulléens, dont Actœon est le plus archaïque ;

2° Les Nudibranches dérivent des Tritoniidæ, et ceux-ci eux-mêmes proviennent de Tectibranches voisins de Pleurobranchœa ;

3° Les Pulmonés Slylommatophores dérivent des Auriculidæ, qui sont les plus archaïques des Basommalophores ; et ceux-ci proviennent de Tectibranches Bulléens, voisins de Actœon ;

4° Les Gastropodes ne sont pas diphylétiques. Les Eulhyneures (= Opisthobranches + Pulmonés) ont des relations génétiques avec les Streptoneures ; les Tectibranches archaïques (Bulléens et spécialement Actœon) proviennent de Streptoneures dont les Rhipidoglosses Trochoïdes sont les formes les plus voisines parmi les Mollusques actuels ;

5° La torsion caractéristique des Streptoneures est atténuée chez les Eulhyneures par une délorsion (torsion en sens inverse) dont l’importance croit avec la spécialisation.
Wavelet analysis of electroencephalograms of patients with epilepsy
Authors:   Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Medievsky A.V. , Kirillova S.V. , Kirillov K.A. , Zotin A.G. , Simonov K.V. ,   Siberian Federal University
Published: November 2023

The study of the wavelet characteristics of the signal makes it possible to identify characteristic patterns in the patterns of physiological rhythms of a healthy person and determine changes in the dynamic complexity of the patterns in the event of various pathological conditions. The paper shows the possibility of using the wavelet characteristics of EEG patterns (electroencephalogram) for automatic detection of epileptiform discharges. A method is proposed for determining EEG frequencies related to noise. The possibilities of compression and filtering of EEG signals are shown. A computational technique for analyzing EEG signals in relation to epilepsy has been developed.
Disputas en torno de la alegoría en la literatura de Juan José Saer
Authors: Pastoriza Malena
Published: November 2023

La institucionalización de la literatura de Juan José Saer converge con los diagnósticos críticos acerca del giro alegórico de la literatura argentina de fines de los años setenta, en tanto se interpreta Nadie nada nunca como una novela de la dictadura. Ha sido ampliamente destacado el rol de las intervenciones de Beatriz Sarlo en este proceso. El propósito del artículo es analizar el conjunto de operaciones críticas que sostienen la noción de alegoría puesta en juego por Sarlo en esos trabajos, que inauguran la lectura en clave alegórica de la obra saeriana. Buscamos demostrar que en ella conviven concepciones heterogéneas y por momentos contradictorias, y que las huellas de esta tensión pueden rastrearse en la tendencia anti-alegórica de la crítica saeriana reciente.
ANCHORAGE DESIGN FOR BLAST-RESISTANT WINDOWS
Authors: Saatcioglu Murat , Alameer Alameer Marai
Published: November 2023

This paper presents a summary of experimental research on the performance of blast-resistant window anchors and the development of a design procedure for the anchors. The experimental results, obtained from forty-six window tests conducted under simulated blast loading using a shock tube are reported. Two analysis procedures that were developed for anchor design are described. The first procedure involves a two-degree-of-freedom dynamic analysis. The second procedure involves a single degree of freedom analysis that can be implemented manually. The development of both methods is presented for the anchorage design of windows subjected to blast loads.
الأخصائيين الاجتماعيين كضحية لعنف العملاء
Authors: Taha Sara
Published: November 2023

الأهداف: هدفت الدراسة إلى كشف بعض الحقائق ذات العلاقة بتعرض الأخصائيين الاجتماعيين للممارسات العنيفة من قبل عملائهم في أثناء ممارسة مهنة العمل الاجتماعي؛ حيث هدفت إلى التوصل إلى أبرز أشكال العنف الممارس عليهم، وأهم الأسباب التي تدفع العملاء للممارسة العنف ضدهم. كما سعت لتعرُّف تأثير هذه الظاهرة في الأخصائيين الاجتماعيين وفي مهنة العمل الاجتماعي ككل.
المنهجية: جرى اعتماد المنهج النوعي لاستكمال جمع بيانات الدراسة من خلال مقابلة 20 أخصائي اجتماعي من كلا الجنسين على نحو فردي، وقد جرى اختيارهم بطريقة قصدية باستخدام تقنية كرة الثلج.
النتائج: وبعد تحليل البيانات باستخدام منهجية التحليل الموضوعي الاستقرائي توصلت الدراسة إلى أن الأخصائيين الاجتماعيين يتعرضون للعديد من أشكال العنف الممارس من قبل العملاء، وأن العنف اللفظي هو الأكثر شيوعًا، وقد عبَّر الأخصائيين الاجتماعيين عن تعرضهم لمجموعة من الأضرار النفسية والاجتماعية نتيجة لهذا السلوك. أما من الناحية المهنية، فبالرغم من كل الآثار السلبية للسلوك العنيف في الأخصائيين الاجتماعيين، إلا أن ذلك لم يؤثر على نحو كبير في دافعيتهم للمهنة.
التوصيات: اقترحت الدراسة مجموعة من التوصيات للحد من السلوك العدواني تجاه الأخصائيين الاجتماعيين، وتمحورت أبرز الأفكار حول ضرورة إصدار سياسات وتشريعات تضمن حماية الأخصائيين الاجتماعيين في بيئة العمل.
القدرة التنبؤية للعوامل الخمس الكبرى للشخصية بسلوك المساعدة لدى الطلاب الدوليين بالجامعة الإسلامية
Authors: Almailabi Bandar Salah
Published: November 2023

الأهداف: هدفت الدراسة الحالية إلى الكشف عن مستوى سلوك المساعدة، ودرجة العوامل الخمسة الكبرى للشخصية، وتعرُّف الفروق بينهما، كما سعت إلى التحقق من الفرض البحثي الخاص بالقدرة التنبؤية لأبعاد العوامل الخمسة الكبرى للشخصية بسلوك المساعدة لدى الطلاب الماليين، والإندونيسيين، والموريتانيين بالجامعة الإسلامية بالمدينة المنورة.
المنهجية: اتبعت الدراسة المنهج الوصفي التنبؤي، مستخدمة مقياس سلوك المساعدة لكابرارا وزملاؤه (Caprara, et al., 2005)، ومقياس العوامل الخمسة الكبرى للشخصية لـ "سوتو وجون" (Soto & John, 2017). وطُبِّقتْ أداتا الدراسة- بعد التحقق من صلاحيتها- على عينة طبقية انتقائية مكونة من (347) طالب في الجامعة الإسلامية.
النتائج: خلصت النتائج إلى مستوى مرتفع جدًا من سلوك المساعدة لدى أفراد العينة. وجاءت مستويات العوامل الخمسة الكبرى للشخصية متباينة بين المستجيبين؛ إذ جاء عامل العاطفة السلبية منخفضًا، وعاملي الانبساطية والانفتاح متوسطًا، بينما جاء عاملي الوادعة والتفاني مرتفعًا. وأخيرًا، كشفت النتائج عن تحقق الفرض البحثي جزئيًا؛ إذ أسهمت متغيرات الانبساطية، والوداعة، والانفتاح (بصفتها منبئات موجبة)، والعاطفة السلبية (بصفته منبئًا سالبًا) التنبؤ بسلوك المساعدة، في حين فشل متغير التفاني في ذلك.
الخلاصة: لما كان سلوك المساعدة لدى طلاب الجامعة الإسلامية مرتفعًا؛ وجب على القائمين بالنشاطات الطلابية الإفادة من هذه المِيزة من خلال اشراكهم في البرامج التطوعية وخدمة المجتمع المدني. ونظرًا إلى ما يواجهه الطلاب الموريتانيين من عاطفة سلبية متوسط الدرجة- كشفت عنها نتائج الدراسة- يُفضل معها تقديم خدمات إرشادية عبر المركز الإرشادي بالجامعة؛ لخفض مشاعرهم السلبية.
Transformaciones del pensamiento ético: continuidades y rupturas. Volumen II
Authors: Díaz Novoa Gildardo , Zabala Hernández Mauricio , Díaz Santacruz Carolina , Suleiman Sanabria Hans , Coba-Gutiérrez Patricia
Published: November 2023

El propósito de este ejercicio reflexivo es examinar y explorar los avances y cambios en el ámbito de la filosofía moral, desde la segunda mitad del siglo xx hasta el presente, teniendo en cuenta la diversidad y pluralidad en la evolución de lo ético. La definición de lo humano está ligada al tiempo y al espacio, por lo tanto somos seres indefinidos, provisionales, insuficientes e insatisfechos. El rastreo de las diversas versiones y tradiciones del fenómeno moral se realiza con la intención de comprender sus implicaciones y vitalidad en el contexto actual. Es importante mencionar que en este ejercicio reflexivo se utilizó el método hermenéutico debido a su valor para la comprensión e interpretación de textos y discursos filosóficos. La hermenéutica conlleva analizar el significado de los conceptos éticos y su evolución a lo largo del tiempo, considerando el contexto histórico y cultural en el que surgieron. Se busca comprender cómo estos conceptos han sido recibidos y reinterpretados en diferentes tradiciones y corrientes filosóficas. El uso de este método permitió una reflexión profunda y rigurosa sobre el tema de la filosofía moral y su relevancia en el mundo actual.
Analisis Kinerja Keuangan Menggunakan Analisis Dupont Sistem (Studi Empiris Pada PT Sumber Alfaria Trijaya Tbk Periode 2019-2022)
Authors: Oktaviani Azzahara Rita , Sentosa Nona Abigail , Rostiani Yeny , Rustiadi Rizzky
Published: November 2023

Penelitian ini bertujuan untuk menganalisis kinerja keuangan menggunakan anailis DuPont pada PT  PT Sumber Alfaria Trijaya Tbk, menggunakan laporan auditan  tahun 2019 – 2022 yang dipublikasikan di  Bursa Efek Indonesia. hasil analisis data diperoleh bahwa tingkat Net Profit Margin (NPM) pada tahun 2022   mengalai peningkatn, Hal ini disebabkan karena adanya peningkatan pada laba bersih dan penjualan. Peningkatan laba bersih disebabkan meningkatnya penjualan, penambahan jumlah gerai, dan pendapatan  lainya.  Hasil perhitungan otal Asset Turnover hasil perhitungan mengalami peningkatan di tahun 2022 sebesar 3,15 kali (naik 0,05 kali) dari 3,10 kali pada tahun 2021.  Hal ini disebabkan karena adanya penurunan penjualan dan total aset.  Return on Investment  (ROI ) tahun 2022 mengalami peningkatan sebesar 0,094% (naik 0,023%) dari 0,094% pada tahun 2021. Hal ini disebabkan karena Net Profit Margin mengalami penurunan dan Total Asset Turnover mengalami peningkatan. . Hasil perhitungan Return on Equity (ROE) pada tahun 2022 mengalami peningkatan sebesar 0,25% (naik 0,05%) dari 0,20 pada tahun 2021. Hal ini disebabkan oleh Return on Investment mengalami penurunan dan Equity Multiplier mengalami peningkatan.