bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
Authors: Kong Linghui , Yin Hong , Zhou Danran , Li Xin , Zhou Jie
Published: June 2024

Understanding the intricate relationship between cancer clinicopathological features and anesthetics dosage is crucial for optimizing patient outcomes and safety during surgery. This retrospective study investigates this relationship in patients with non-small cell lung cancer (NSCLC) undergoing video-assisted thoracic surgery (VATS). A comprehensive analysis of medical records was undertaken for NSCLC patients who underwent VATS with intravenous compound inhalation general anesthesia. Patients were categorized based on histological, chemotherapy, radiotherapy, and epidural anesthesia factors. Statistical analysis was performed to compare the differences between the groups. The results revealed compelling insights. Specifically, patients with lung adenocarcinoma (LUAD) undergoing VATS exhibited higher dosages of rocuronium bromide and midazolam during general anesthesia, coupled with a shorter post-anesthesia care unit (PACU) stay compared to those with squamous cell carcinoma (sqCL). Furthermore, chemotherapy patients undergoing VATS demonstrated diminished requirements for phenylephrine and remifentanil in contrast to their non-chemotherapy counterparts. Similarly, radiotherapy patients undergoing VATS demonstrated a decreased necessity for rocuronium bromide compared to non-radiotherapy patients. Notably, patients who received epidural anesthesia in combination with general anesthesia manifested reduced hydromorphone requirements and prolonged hospital stays compared to those subjected to general anesthesia alone. In conclusion, the findings from this study indicate several important observations in diverse patient groups undergoing VATS. The higher dosages of rocuronium bromide and midazolam in LUAD patients point to potential differences in drug requirements among varying lung cancer types. Additionally, the observed shorter PACU stay in LUAD patients suggests a potentially expedited recovery process. The reduced anesthetic requirements of phenylephrine and remifentanilin chemotherapy patients indicate distinct responses to anesthesia and pain management. Radiotherapy patients requiring lower doses of rocuronium bromide imply a potential impact of prior radiotherapy on muscle relaxation. Finally, the combination of epidural anesthesia with general anesthesia resulted in reduced hydromorphone requirements and longer hospital stays, suggesting the potential benefits of this combined approach in terms of pain management and postoperative recovery. These findings highlight the importance of tailoring anesthesia strategies for specific patient populations to optimize outcomes in VATS procedures.
Hepatic function of glucagon-like peptide-1 and its based diabetes drugs
Authors: Feng Jia Nuo , Jin Tianru
Published: June 2024

Incretins are gut-produced peptide-hormones that potentiate insulin secretion, especially after food intake. The concept of incretin was formed more than 100 years ago, even before insulin was isolated and utilized in the treatment of subjects with type 1 diabetes. The first incretin, glucose-dependent insulinotropic polypeptide (GIP), was identified during later 1960’s and early 1970’s; while the second one, known as glucagon-like peptide-1 (GLP-1), was recognized during 1980’s. Today, GLP-1-based therapeutic agents [also known as GLP-1 receptor (GLP-1R) agonists, GLP-1RAs] are among the first line drugs for type 2 diabetes. In addition to serving as incretin, extra-pancreatic functions of GLP-1RAs have been broadly recognized, including those in the liver, despite the absence of GLP-1R in hepatic tissue. The existence of insulin-independent or gut-pancreas-liver axis-independent hepatic function of GLP-1RAs explains why those therapeutic agents are effective in subjects with insulin resistance and their profound effect on lipid homeostasis. Following a brief review on the discovery of GLP-1, we reviewed literature on the exploration of hepatic function of GLP-1 and GLP-1RAs and discussed recent studies on the role of hepatic hormone fibroblast growth factor 21 (FGF21) in mediating function of GLP-1RAs in animal models. This was followed by presenting our perspective views.
Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases
Authors: Wang Yanyan , Xu Huangru , Zhou Xiqiao , Chen Weidong , Zhou Huiping
Published: June 2024

Maintaining bile acid homeostasis is essential for metabolic health. Bile acid homeostasis encompasses a complex interplay between biosynthesis, conjugation, secretion, and reabsorption. Beyond their vital role in digestion and absorption of lipid-soluble nutrients, bile acids are pivotal in systemic metabolic regulation. Recent studies have linked bile acid dysregulation to the pathogenesis of metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction-associated steatotic liver disease (MASLD). Bile acids are essential signaling molecules that regulate many critical biological processes, including lipid metabolism, energy expenditure, insulin sensitivity, and glucose metabolism. Disruption in bile acid homeostasis contributes to metabolic disease via altered bile acid feedback mechanisms, hormonal dysregulation, interactions with the gut microbiota, and changes in the expression and function of bile acid transporters and receptors. This review summarized the essential molecular pathways and regulatory mechanisms through which bile acid dysregulation contributes to the pathogenesis and progression of obesity, T2DM, and MASLD. We aim to underscore the significance of bile acids as potential diagnostic markers and therapeutic agents in the context of metabolic diseases, providing insights into their application in translational medicine.
Morphological and yield trait-based evaluation and selection of chili (Capsicum annuum L.) genotypes suitable for both summer and winter seasons
Authors: Ratna Mahmuda , Chowdhury Abul Kashem , Mahmud Firoz , Rohman Md. Motiar , Ali Mohammad Zulficar , Syed Md. Abu , Almoallim Hesham S. , Ansari Mohammad Javed , Hossain Akbar
Published: June 2024

Chili (Capsicum annuum L.) is one of the most important vegetable cum spice crops grown throughout the world. Evaluation of genotypes based on morphological and yield contributing traits provides the opportunity to assess variability and select superior genotypes. The present investigation was carried out from April 2018 to November 2018 in the summer season and from December 2018 to June 2019 in the winter season in a net house and field, respectively, in the Department of Genetics and Plant Breeding, Patuakhali Science and Technology University, Patuakhali, Bangladesh. A set of 30 qualitative and 13 quantitative characteristics developed by Biodiversity International were recorded to evaluate the genotypes for morphological and yield-contributing traits. The estimated Shannon–Weaver diversity for qualitative traits ranged from 0 to 1.334, where the maximum diversity was recorded for fruit color at an intermediate stage, stem color after transplanting, fruit surface, stigma position, calyx margin shape, and fruit set, while the minimum diversity (H′ = 0) was observed for the traits corolla shape and anthocyanin spots, indicating no diversity of these traits. Thirteen quantitative traits were also analyzed for the selection of the genotypes with the greatest yield. The quantitative traits also exhibited a wide range of variability according to descriptive statistics and analysis of variance. Moreover, the present study revealed a high heritability for almost all of the quantitative traits, which was confirmed by the values of genotypic coefficient of variation, phenotypic coefficient of variation, h
2
b, and GA for both the summer and winter seasons. This suggests that these traits are predominantly governed by additive genes, making them highly amenable to effective selection. The heatmap analysis based on the morphological quantitative traits revealed five clusters for both the summer and winter seasons for the studied chili genotypes, four distinct clusters in the summer season, and three distinct clusters in the winter season for the parameters studied. Using the multi-trait genotype–ideotype distance index based on multiple trait information, the genotypes R-06, R-07, C0525-2, BARI (Bangladesh Agricultural Research Institute) Morich-2, Tengakhali, and Rcy 002 were selected as promising for both the summer and winter seasons. Hence, they are recommended for commercial cultivation or use as parent materials in future breeding for the development of new cultivars adaptable to climate change.
Two-phase numerical simulation of thermal and solutal transport exploration of a non-Newtonian nanomaterial flow past a stretching surface with chemical reaction
Authors: Vinothkumar Balaji , Saadeh Rania , Poornima Tamalapakula , Qazza Ahmad , Sreenivasulu Pandikunta , Subba Rao Annasagaram , Khan Umair , Siddiqui Md Irfanul Haque
Published: June 2024

Non-uniform heat sources and sinks are used to control the temperature of the reaction and ensure that it proceeds at the desired rate. It is worldwide in nature and may be found in all engineering applications such as nuclear reactors, electronic devices, chemical reactors, etc. In food processing, heat is used to cook such as microwave ovens, pasteurize infrared heaters, and sterilize food products. Non-uniform heat sources are mainly used in biomedical applications, such as hyperthermia cancer treatment, to target and kill cancer cells. Because of its ubiquitous nature, the idea is taken as our subject of study. Heat and species transfer analysis of a non-Newtonian fluid flow model under magnetic effects past an extensible moving sheet is modelled and examined. Homogeneous chemical reaction inside the fluid medium is also investigated. This natural phenomenon is framed as a set of Prandtl boundary layer equations under the assumed convective surface boundary constraint. Self-similarity transformation is employed to convert framed boundary layer equations to ordinary differential equations. The resultant system is solved using the efficient finite difference utilized Keller box method with the help of MATLAB programming. The influence of various fluid-affecting parameters on fluid momentum, energy, species diffusion and wall drag, heat, and mass transfer coefficients is studied. Accelerating the Weissenberg number decelerates the fluid velocity. The temperature of the fluid rises due to variations in the non-uniform heat source and sink parameters. Ohmic dissipation affects the temperature profile significantly. Species diffusion reduces when thermophoresis parameter and non-uniform heat source and sink parameters vary. The Eckert number enhances the heat and diffusion transfer rate. Increasing the chemical reaction parameter decreases the shear wall stress and energy transmission rate while improving the diffusion rate. The wall drag coefficient and Sherwood number decrease as the thermophoretic parameter increases whereas the Nusselt number increases. We hope that this work will act as a reference for future scholars who will have to deal with urgent problems related to industrial and technical enclosures.
Supplementary cementitious materials-based concrete porosity estimation using modeling approaches: A comparative study of GEP and MEP
Authors: Tian Qiong , Lu Yijun , Zhou Ji , Song Shutong , Yang Liming , Cheng Tao , Huang Jiandong
Published: June 2024

Using supplementary cementitious materials in concrete production makes it eco-friendly by decreasing cement usage and the corresponding CO2 emissions. One key measure of concrete’s durability performance is its porosity. An empirical prediction of the porosity of high-performance concrete with added cementitious elements is the goal of this work, which employs machine learning approaches. Binder, water/cement ratio, slag, aggregate content, superplasticizer (SP), fly ash, and curing conditions were considered as inputs in the database. The aim of this study is to create ML models that could evaluate concrete porosity. Gene expression programming (GEP) and multi-expression programming (MEP) were used to develop these models. Statistical tests, Taylor’s diagram, R
2 values, and the difference between experimental and predicted readings were the metrics used to evaluate the models. With R
2 = 0.971, mean absolute error (MAE) = 0.348%, root mean square error (RMSE) = 0.460%, and Nash–Sutcliffe efficiency (NSE) = 0.971, the MEP provided a slightly better-fitted model and improved prediction performance when contrasted with the GEP, which had R
2 = 0.925, MAE = 0.591%, RMSE = 0.745%, and NSE = 0.923. Binder, water/binder ratio, curing conditions, and aggregate content had a direct (positive) relationship with the porosity of concrete, while SP, fly ash, and slag had an indirect (negative) association, according to the SHapley Additive exPlanations study.
Interfacing the IoT in composite manufacturing: An overview
Authors: Gowtham Palanirajan , Jayasheela Moses , Sivamani Chinnaswamy , Balaji Devarajan
Published: June 2024

It is a well-known fact that many sophisticated works consume a lot of human resources, leading to the need to find effective alternative. The manufacturing industry demands a lot of human resources, with around half of the global working population participating in this sector. Challenges such as sudden conflicts in the data, disasters, and loss of productivity are encountered by the manufacturing industries and can be overcome by monitoring machine performance data and automatically configuring the machines according to changing needs. This emphasizes the importance of the Internet of Things (IoT) in addressing niche areas of manufacturing. IoT is a buzzword heard everywhere around the globe. Implementing this technology makes most of the work more accessible than other conventional methods. This has created a lot of research interest on this topic. Among many manufacturing sectors, polymer composite material manufacturing is one of the most demanding. This review article purely focuses on polymer composite manufacturing and its allied processes. The consolidation of data is based on the influence of IoT on the extraction of fibers and manufacturing of polymer composite material using novel techniques, quality assessment of manufactured polymer composite material, challenges faced in exploring the use of IoT, and future scope. It can be stated from the survey that various researchers have minimally explored the incorporation of IoT, but its future looks very promising in terms of producing high-quality products at less time and lower cost by integrating this technique with conventional methods.
Simulation algorithms for stationary sequences with distributions in the form of a mixture of Gaussian distributions
Authors: Akenteva Marina S. , Kargapolova Nina A. , Ogorodnikov Vasily A.
Published: June 2024

In this paper, we present three algorithms for simulation of intervals of stationary vector and scalar sequences with partial distributions of their subsequences of fixed length in the form of a mixture of Gaussian distributions. The first algorithm is based on superposition of two Gaussian vector processes and the second and third ones use the method of conditional distributions and the method of superpositions to simulate the mixtures and to select realizations for approximate construction of conditional realizations. Some properties of these algorithms are presented.
Monte Carlo simulation of polarized lidar returns for atmospheric clouds sensing
Authors: Prigarin Sergei M. , Kablukova Evgenia G. , Zhang Xue
Published: June 2024

The paper deals with Monte Carlo simulation of polarized radiative transfer and lidar returns in sensing of atmospheric clouds. The Stokes parameters were used to describe the transfer of polarized radiation, and computation of the lidar returns was based on flux-at-point estimators. We consider modifications of the numerical algorithm with scattering according to the phase function for unpolarized light and with scattering depending on polarization. Numerical experiments were performed for lidar sensing of waterdrop clouds.
Making sense of pain in inflammatory bowel disease (IBD): A qualitative study
Authors: Kacorova Adela , Williams Amanda C. de C.
Published: June 2024

Objectives

Inflammatory bowel disease (IBD) is a chronic, gastrointestinal tract condition, in which pain is one of the most widespread and debilitating symptoms, yet research about how individuals make sense of their IBD pain is lacking. The current study aimed to explore how individuals with IBD understand their pain.

Methods

Twenty participants, recruited via the Crohn’s & Colitis UK charity, were interviewed about their understanding of their IBD pain using the Grid Elaboration Method that elicits free associations on which it invites elaboration. Thematic analysis was used to organise transcribed verbatim data.

Results

Three related themes – making sense of my pain, navigating my care and support and it takes its toll – comprising seven sub-themes, illustrated the ways in which participants made sense of pain experientially, multi-dimensionally, and in the broader context of IBD and its symptoms. The psychological impact of pain was evident across all interviews.

Conclusions

The findings are consistent with other research in IBD pain, demonstrating the importance of pain in IBD. Sense-making underpins both emotional and practical responses to pain and ideally is constructed as an integral part of clinical care of IBD.
Evaluation of adropin indices and PCSK9 in non-diabetic men with severe obstructive sleep apnea
Authors: Deniz Levent , Aral Hale , Akdoğan Özlem , Arslan Hilmi Furkan , Yiğit Enes
Published: June 2024

Objectives

We aimed to investigate the relationship among proprotein convertase subtilisin/kexin type 9 (PCSK9), adropin levels, inflammation, and sleep variables in non-diabetic males with severe obstructive sleep apnea (OSA).

Methods

This cross-sectional study included adults aged 18 to 65 who underwent polysomnography due to sleep problems between July 2019 and August 2020. Participants were grouped based on their apnea-hypopnea index (AHI). We included 32 males with simple snoring (AHI<5 events/h) as the controls and 48 males with severe OSA (AHI≥30 events/h). Furthermore, patients with severe OSA were divided into two groups based on body mass index (BMI), resulting in three groups in total. Adropin and PCSK9 were analyzed using the enzyme-linked immunosorbent assay method.

Results

In severe OSA with BMI≥30 kg/m2, compared to the controls, blood pressure values, interleukin-6 (IL-6), white blood cell (WBC) count, systemic inflammation response index, neutrophil, monocyte counts were found to be higher, but adropin/BMI, adropin/waist circumference, adropin/neck circumference were significantly lower. Adropin/BMI had the highest correlation coefficient with IL-6. Although there was no significant difference in PCSK9 levels among the groups, PCSK9 was independently correlated with the WBC and its subsets.

Conclusions

Our study is of clinical importance as it is the first to show a relationship between PCSK9 and inflammation markers in severe OSA. Also, this study demonstrated the potential value of adropin, in combination with BMI, as a valuable indicator for assessing inflammation and OSA severity.
Szerkesztői előszó
Authors: Varga Katalin
Published: June 2024

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RECENZIÓ DANIEL JARCZOK (RED./SZERK.): „EISENBAHNEN – VOM „ADLER” ZUR „MAXIMA” („VASUTAK AZ „ADLERTŐL” A „MAXIMÁIG”) CÍMŰ KÖTETÉRŐL
Authors: Bércesi Richárd
Published: June 2024

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ANÁLISIS COMPARATIVO DEL CAMBIO DE LOS USOS DE SUELO Y VEGETACIÓN DE LA MICRORREGIÓN TLAXCALA-APIZACO PERIODO 2013-20211
Authors: Pérez Martínez J. , Ortega López G. , Leija Loredo E. G.
Published: June 2024

El presente trabajo, expresa el cambio, modificación y la ganancia de uso de suelo urbano en el estado de Tlaxcala, la cual ha dejado como consecuencia la perdida de otros usos de suelo, restando terreno agrícola, pastizales y zonas de bosque, lo que a su vez también refleja la pérdida de producción agrícola, vegetación y especies. La urbanización va ganando terreno en este Estado, al mismo tiempo se van perdiendo micro ecosistemas que equilibran en general nuestro ambiente en el que nos desarrollamos. Existen necesidades básicas del ser humano a cubrir, una de ellas es la vivienda, los servicios básicos y el crecimiento económico, a los cuales damos prioridad en este planeta, debemos reflexionar sobre estas prioridades que traerán consecuencias ambientales en años posteriores.
RELACIÓN ENTRE ASENTAMIENTOS RURALES Y LA MOVILIDAD DE LAS CIUDADES, CASO DE SAN FELIPE HUEYOTLIPAN
Authors: Campero Rodríguez C. N. , Mota Montaño N. A. , López Sánchez L. A.
Published: June 2024

La conurbación es un fenómeno conocido en todas las ciudades, en un principio, esto se apreciaba con la integración de los asentamientos rurales a las urbes en proceso de crecimiento debido a la alta demanda de territorio para expandirse, pero la estructura rural del espacio, sus servicios y equipamientos no estaban preparados para servir a mayores cantidades de personas, resultando insuficientes. Para que el proceso de cambio tuviera el éxito deseado era necesario una buena planificación y tiempo para llevarla a cabo, gracias a que ninguna de las dos fue posible, actualmente se aprecia una menor calidad de vida para los habitantes de colonias que antiguamente eran asentamientos rurales. Este escrito presenta el diagnóstico del sistema de movilidad del caso particular de la colonia San Felipe Hueyotlipan, Puebla, estudiado de finales de 2022 a 2023; por ser donde se concentran loselementos urbanos claves para identificar las malas prácticas de planeación, diseño y adaptación de los asentamientos rurales al momento en que se unen a un asentamiento de mayor tamaño y demandas. Se exponen las principales amenazas y fortalezas de la movilidad que han persistido a lo largo del tiempo en la colonia San Felipe Hueyotlipan, así como la necesidad de priorizar elementos específicos dentro del mismo sistema de movilidad para lograr la mitigación de fenómenos o problemáticas relacionados con la calidad de vida, la habitabilidad y accesibilidad al entorno urbano de los habitantes de asentamientos antes rurales que no lograron adaptarse de forma correcta a la gran urbe.
The Relevance of Creating an Integral Pedagogical System of Career Guidance Work with Students of Different Levels of Education
Authors:   Herzen State Pedagogical University of Russia, Kondratieva Svetlana Yu. , Kovaleva Maria V. ,   Herzen State Pedagogical University of Russia
Published: June 2024

Introduction. The article reveals the issues of organizing career guidance and mentoring activities at a university through a description of holistic career guidance work with students of different levels of education in the “school – university” system; areas of career guidance work are considered; passive and active methods used in the implementation of career guidance activities are described. Methodology. The methodological basis of the study was based on the principles of the system-activity approach and the competence approach. To achieve the research goal, theoretical (analysis, synthesis, generalization and systematization of scientific publications data) and empirical (observation, survey) methods were used. Results. The authors have revealed an integrated pedagogical system of career guidance work with students of different levels of education, described the main directions of career guidance through the implementation of activities implemented at the university with school-age students and students, characterized the advantages of implementing an integrated pedagogical system of career guidance work with students. Conclusions. An integrated pedagogical system of career guidance is an important condition for the functioning of a university in a competitive environment. The innovative component of the presented holistic pedagogical system of career guidance work consists in the implementation of a continuous system of career guidance (“school – university”, “student – entrant – student – young specialist”), as well as in conducting career guidance and educational activities with students of different levels of education.
Prospects for the Functioning of the Technological Park of Universal Pedagogical Competencies in the Implementation of Educational Projects on the Example of Studying the Topic “Energy Exchange in a Cell”
Authors:   Novosibirsk State Pedagogical University, Pirogova Anna S. , Arbuzova Elena N. ,   Omsk State University named after F. M. Dostoevsky, Yakovleva Maria D. ,   Novosibirsk State Pedagogical University, Loshenko Vitalina I. ,   Novosibirsk State Pedagogical University, Makeev Aleksandr A. ,   Novosibirsk State Pedagogical University, Sakharov Andrey V. ,   Novosibirsk State Pedagogical University
Published: June 2024

Introduction. The article discusses the issues of one of the most difficult topics in teaching biology at school and university. The aim of the work was to determine the reasons for the low level of assimilation of educational material related to the study of the topic “Energy metabolism”. Methodology. The authors analyzed the content of school biology textbooks of different authors for their scientific component, unity of theory and practice, accessibility and visibility, systematic and consistent presentation of material devoted to the study of energy metabolism. Results. The results of the study showed that one of the reasons for the complexity of learning the topic “Energy metabolism” may lay not in the subject area, but in the specifics of the methodology of teaching biology in general education organizations. In the conditions of the pedagogical experiment the results were obtained, which allow us to evaluate the methodology of teaching biology proposed by teachers of the pedagogical university when studying the topic “Energy metabolism”. Conclusion. From the position of teaching biological disciplines in the “school – university” system, a view on the need to develop educational and methodological support for the educational activity of general educational organizations is presented. It should be based on the application of immersive technologies of augmented, mixed and virtual reality, as well as the possibilities of the technopark of universal pedagogical competencies. It will be based on the leading principles and systems of “Theory and methods of teaching (education) of biology” as a pedagogical science.
The Educational Environment of the University as a Factor in Optimizing Foreign Language Teaching
Authors:   Russian Presidential Academy of National Economy and Public Administration, Galushkin Alexey V.
Published: June 2024

Introduction. The article is devoted to the problem of organizing the educational environment of a university, taking into account the factors that influence the success of mastering a foreign language course. The purpose of the study is to identify and substantiate the influence of educational environment factors, the combination of which contributes to the successful acquisition of a foreign language course at a university. Methodology. The methodological basis of the research is the methods of historical and comparative analysis of existing publications on the methodology, pedagogy and psychology of teaching foreign languages, as well as a comparative interpretation of their individual provisions. Results. The elements of the educational environment of the university are highlighted, which not only contribute to improving the academic performance of students, but also have a direct impact on the success of mastering a foreign language course, as well as the formation of personal qualities of students. Conclusions. The educational environment of the university is a complex, organized structure, the combination of elements of which has a positive impact on the success of the educational process in general and the process of learning a foreign language in particular.
Differential regulation of STARD1, STARD4 and STARD6 in the human ovary
Authors: Yahya Nawal A , King Steven R , Shi Bo , Shaaban Aisha , Whitfield Nicole E , Yan Chunmei , Kordus Richard J , Whitman-Elia Gail F , LaVoie Holly A
Published: June 2024

Cells actively engaged in de novo steroidogenesis rely on an expansive intracellular network to efficiently transport cholesterol. The final link in the transport chain is STARD1, which transfers cholesterol to the enzyme complex that initiates steroidogenesis. However, the regulation of ovarian STARD1 is not fully characterized, and even less is known about the upstream cytosolic cholesterol transporters STARD4 and STARD6. Here, we identified both STARD4 and STARD6 mRNAs in the human ovary but only detected STARD4 protein since the primary STARD6 transcript turned out to be a splice variant. Corpora lutea contained the highest levels of STARD4 and STARD1 mRNA and STARD1 protein, while STARD4 protein was uniformly distributed across ovarian tissues. Cyclic AMP analog (8Br-cAMP) and phorbol ester (PMA) individually increased STARD1 and STARD4 mRNA along with STARD1 protein and its phosphoform in cultured primary human luteinized granulosa cells (hGCs). STARD6 transcripts and STARD4 protein were unresponsive to these stimuli. Combining lower doses of PMA and 8Br-cAMP blunted the 8Br-cAMP stimulation of STARD1 protein. Increasing cholesterol levels by blocking its conversion to steroid with aminoglutethimide or by adding LDL reduced the STARD4 mRNA response to stimuli. Sterol depletion reduced the STARD1 mRNA and protein response to PMA. These data support a possible role for STARD4, but not STARD6, in supplying cholesterol for steroidogenesis in the ovary. We demonstrate for the first time how cAMP, PMA and sterol pathways separately and in combination differentially regulate STARD4, STARD6 and STARD1 mRNA levels, as well as STARD1 and STARD4 protein in human primary ovarian cells.
Percepción de los factores de riesgo en la salud física y mental de los empleados, causados por la modalidad de trabajo en casa durante el inicio de la pandemia por Covid-19, caso Alcaldía de Villavicencio (Meta)
Authors: Prieto Delgadillo Mario Fernando , Sarmiento Suárez Gisela Patricia , Pajón Rojas Camila
Published: June 2024

Durante la pandemia de Covid-19, las empresas se vieron obligadas a enviar a su capital humano a trabajar desde casa, lo que causó un evidente riesgo en la salud, derivado de la multiplicidad de cambios que se generaron como consecuencia de esta enfermedad. Este estudio de caso tuvo una metodología de investigación mixta, en el cual se obtuvo información a profundidad a partir de las narraciones de los trabajadores de la Alcaldía de Villavicencio. Se evidenció la inadecuada adaptación o transición de las empresas y de la sociedad a los cambios durante la pandemia, lo cual produjo altos niveles de estrés, afectando el bienestar de las personas, pues se hizo visible que estos cambios sobrepasaron sus capacidades.
Validez jurídica de los contratos celebrados en la Blockchain
Authors: Quintero Perdomo Luisa Alejandra
Published: June 2024

Con los constantes avances en tecnología se ha reinventado la forma como se concebía el derecho, ahora, hablamos de audiencias virtuales, inclusive audiencias en el metaverso, mensajes de datos con información jurídicamente válida o con fuerza obligatoria, nuevas formas de contratación en lo relacionado con el e-commerce y, en lo que concierne al presente artículo, un nuevo medio de expresión contractual conocido como Smart-Contract que existe dentro del popular mundo tecnológico de la Blockchain. Esta nueva figura ha sido objeto de estudio en varios sectores de la doctrina y en algunos casos se ha discutido sobre su validez jurídica. Diferentes opiniones sobre la existencia y validez jurídica de los contratos finalmente permitieron concluir que, los Smart-Contract, por ser parte de las relaciones que regula el derecho privado, gozan de principios como el de autonomía privada, libertad de formas, autodeterminación, equivalencia de las prestaciones, seguridad, confianza y demás pilares básicos que hacen f lexible las formas en que los particulares pueden obligarse y por tanto, a la luz del Código Civil colombiano, es un contrato que vincula a quienes en él plasman su voluntad y que, además, genera efectos frente a terceros, es decir, existe y tiene validez.
Oportunidades en la transformación de las empresas del sector Oil & Gas desde la transición energética justa en el departamento del Meta
Authors: Devia Orjuela Néstor Hernando , Medina Neira Laura Katherine , Arciniegas Barrera Karina Alexandra
Published: June 2024

Este artículo de investigación abarca el nuevo compromiso que debe asumir las empresas del sector Oil & Gas del departamento del Meta en relación con el medio ambiente, enfocándose en la investigación y la innovación para encontrar la manera de adaptarse y ser competitivas en el nuevo entorno, generando una sostenibilidad económica a través de la transición hacia energías de carácter renovable. Por esta razón, las empresas pertenecientes al sector, debe adaptarse a la transición energética enfocándose en las nuevas estrategias globales y políticas de acción.
Singing manuscripts of Antonievo-Siysky monastery at the Synodal singing collection: palaeography and remarks on the history of the monastery and the monastery library
Authors: Grigorjeva Veronika
Published: June 2024

The Synodal Singing Collection of the State Historical Museum contains a complex of singing manuscripts from the Antonievo-Siysky Monastery. Most of them date from the 17th century. It is the time when the domestic tradition of church singing was intensively transformed. In the Antonievo-Siysky Monastery, the process of changes proceeded quite actively, and the Siysky complex of manuscripts is a valuable source on the history of Russian church singing in the transitional period.All types of musical notation, known in the ancient Russian manuscript tradition of the 15th–17th centuries, are presented in the Antonievo-Siysky singing manuscripts, including double-signs (dvoznamenniky), as well as several pre-reform manuscripts with a naon edition, in which cinnabar marks modern to the main text are affixed. The complex allows us to trace how the preferences of the Siya scribes and singers in using this or that type of notation in practice changed during the 16th–18th centuries.According to the edition of the verbal text, the Siysky singing manuscripts are divided into three groups: pre-reform, transitional and post-reform. The variety of editions of the verbal text makes it possible to study the methods of work of Nikon's editors of the Printing House and their monastic followers.The repertoire of chants recorded in the Siysky manuscripts reflects the excellent knowledge of the Siya master-singers both the singing heritage of the end of the 15th–16th centuries and the creative achievements of their contemporaries from the major singing centers of that time.
Суффиксы -ова-, -ева-, -изова-, -ирова-, -изирова- в глагольной неологизации 2000–2020 гг.
Authors: БУЦЕВА Таисия , ЗЕЛЕНИН Александр
Published: June 2024

Статья посвящена исследованию процессов глагольной неологизации в 2000–2020 гг. на материа-ле бесприставочных глаголов, имеющих в своей структуре суффиксы -ова-, -ева-, -изова-, -ирова-, -изирова-. Основной материал взят из готовящегося к печати словаря «Неологизмы XXI века: глаго-лы» под ред. Т. Н. Буцевой. Исследуемый базовый материал – 66 неоглаголов (6,6% от общего объе-ма словника этого словаря, около 1000 глагольных неолексем). Однако при оценке степени узуали-зации новых суффиксальных глаголов учитываются производные: 207 глаголов, образованных от них префиксальным способом и 64 глагола, произведенных постфиксальным способом (с помощью постфикса -ся).

Актуальность темы определяется недостаточной полнотой выявления новых глаголов, во многом обусловленной их относительной немногочисленностью в неологическом потоке, а также отстава-нием их словарной фиксации. Центральная исследовательская проблема статьи – проблематизиро-вать критерии разграничения суффиксальных глагольных новообразований, возникших на русской почве, и глагольных заимствований, суффиксально оформленных при вхождении в русский язык.

Новые глаголы данной словообразовательной структуры описываются на фоне истории форми-рования данных суффиксов в русском языке. В ходе исследования анализируется продуктивность этих формантов в новейшее время, объясняется наблюдаемая орфографическая вариативность, описываются имеющая место словообразовательная синонимия, семантические и стилистические особенности, определяется степень освоенности неоглаголов русским языком, раскрывается сло-вообразовательная потенция новых суффиксально образованных и суффиксально оформленных глаголов.

Цель статьи – представить глагольные неологизмы новейшего периода, образованные и оформ-ленные с помощью суффиксов -ова-, -ева-, -изова-, -ирова-, -изирова-, дать их комплексную характе-ристику, показать динамику неологического процесса через вовлечение этих глаголов в словообра-зовательные процессы. Методами исследования являются словообразовательный, компаративный, классификационный, этимологический, дефиниционный.
Swabian Maultaschen
Authors: Kopf Petra
Published: June 2024

This article looks at maultaschen which, together with spaetzle, are probably among the best-known regional specialities of the German federal state of Baden-Württemberg. Not only are they an essential part of everyday cuisine, they are considered to be a ‘modern soul food’ as well as a symbol of regional identity. The article looks at how their contemporary popularity was achieved through the confluence of various socio-economic, political and cultural changes during the last century.
Syllabub
Authors: Sayers William
Published: June 2024

An etymological study of the word itself and observations about its success.
Joan Morgan: The Book of Pears. The Definitive History and Guide to over 500 Varieties
Authors: Pawley Clare
Published: June 2024

Joan Morgan: The Book of Pears. The Definitive History and Guide to over 500 Varieties: paintings by Elisabeth Dowle: Ebury Press, 2015: 304 pp., hardback, £45.
TRAYECTORIA DEL CONCEPTO DE INCLUSIÓN Y SU INCORPORACIÓN A LAS PRÁCTICAS EDUCATIVAS DE LOS MUSEOS CHILENOS ENTRE 1978 y 2019
Authors: Carvajal Francisca Eloisa Contreras
Published: June 2024

El concepto de inclusión resulta un tema de interés para los museos desde hace varios años, lo que se ve reflejado en su incorporación a la nueva definición de museos. Abordar dicho concepto desde una perspectiva educativa permitiría comprender mejor sus dimensiones y usos en el campo museológico. Por lo tanto, el artículo tiene por objetivo analizar la trayectoria del concepto de inclusión y su incorporación a las prácticas educativas de los museos chilenos mediante la revisión de fuentes documentales entre 1978 y 2019, desde una perspectiva histórica. Se hace un seguimiento a los elementos de participación, acceso y diversidad que caracterizan a la educación inclusiva, marco teórico desde el cual se aborda la inclusión en el contexto de diferentes enfoques museológicos. El estudio nos entrega una perspectiva ampliada sobre los cambios en el uso del concepto de inclusión en los museos, que forma parte de un proceso que se configuró a partir de la formación de una institucionalidad museal y cambios de paradigma en materia de derechos humanos, y que en el presente caracterizan y dan su particularidad a la educación en los museos.
Understanding Sample Generation Strategies for Learning Heuristic Functions in Classical Planning
Authors: Bettker Rafael V. , Minini Pedro P. , Pereira André G. , Ritt Marcus
Published: June 2024

We study the problem of learning good heuristic functions for classical planning tasks with neural networks based on samples represented by states with their cost-to-goal estimates. The heuristic function is learned for a state space and goal condition with the number of samples limited to a fraction of the size of the state space, and must generalize well for all states of the state space with the same goal condition. Our main goal is to better understand the influence of sample generation strategies on the performance of a greedy best-first heuristic search (GBFS) guided by a learned heuristic function. In a set of controlled experiments, we find that two main factors determine the quality of the learned heuristic: the algorithm used to generate the sample set and how close the sample estimates to the perfect cost-to-goal are. These two factors are dependent: having perfect cost-to-goal estimates is insufficient if the samples are not well distributed across the state space. We also study other effects, such as adding samples with high-value estimates. Based on our findings, we propose practical strategies to improve the quality of learned heuristics: three strategies that aim to generate more representative states and two strategies that improve the cost-to-goal estimates. Our practical strategies result in a learned heuristic that, when guiding a GBFS algorithm, increases by more than 30% the mean coverage compared to a baseline learned heuristic.
NUMERICAL INVESTIGATION OF LIQUID-CARRYING AXIAL AND SWIRL FLOW IN A BENT PIPE
Authors: Manimaran Renganathan
Published: June 2024

Water condensation occurs in the sloping sections of natural gas pipelines due to fluctuations in temperature and
pressure. This event has a major effect on the efficiency and security of gas transportation. In this numerical study,
the flow of water via a swirling flow in a wavy pipeline is examined using computational fluid dynamics. A 1-inch
pipe is used to simulate a low-lying area of the pipeline, which is normally where the condensate water would gather.
The effect of swirl on the flow patterns in the U-shaped pipe with previously published experimental results is studied
and validated. In order to comprehend the change of static and dynamic pressure, results are extended in the doubly
undulated pipe (w-pipe). According to the innovative analysis in this study, higher swirl flow could empty the water
build-up faster than swirl flow inlet velocities below 11.2 m/s in a given amount of time. When the effusion volume
increases and the water-carrying capacity is enhanced, several flow regimes, including annular flow, plug flow, slug
flow, stratified wave flow, and stratified flow, are observed along with an increase in air velocity.
Wetting of the retinal surface by perfluorocarbon liquid: implications for retinal detachment surgery
Authors: Ayalon Anfisa , El Zhalka Fidaa , Rubowitz Alexander , Roy Pritam Kumar , Shoval Shraga , Legchenkova Irina , Bormashenko Edward
Published: June 2024

Perfluorocarbon liquids (PFCLs) are essential in ophthalmology due to their unique properties, such as higher density than water, inert chemical nature and optical transparency. They serve as crucial tools in retinal detachment surgery, acting as both intraoperative aids and short-term tamponade agents. However, the interactions between PFCLs and the retinal surface are not fully understood, limiting insights into potential complications. This study investigated the interfacial interaction between perfluorodecalin (PFCL) and the retinal surface. The wetting behavior of animal retinas by water and PFCL was analyzed, revealing the water droplet floating phenomenon in PFCL and calculating the critical radius for this effect. The dynamics of water spreading over the retina were examined. A model experiment demonstrated that the tendency of water to float over PFCL, interacting with a hydrophilic surface such as the retina, could create traction and damage the retinal surface. These findings enhance the comprehension of physical processes at the PFCL/retina interface and offer practical insights for improving ophthalmic surgical procedures.
Communication constraints in the safety system on South African mines and implications for the exercise of the Right to Refuse Dangerous Work
Authors: Coulson N. , Stewart P.F.
Published: June 2024

The Mine Health and Safety Act No. 29 of 1996, as amended, embeds an occupational health and safety management system that facilitates communication between representatives of the state, capital, and labour. In underground mines, two communication loops between these role players serve to separate the production chain of command from the political tripartite relations. Worker-elected health and safety representatives are involved in both communication loops, but are severely constrained in escalating their occupational health and safety concerns to the legal-political level. This has a direct bearing on the exercise of the Right to Refuse Dangerous Work (RRDW). As previously reported, health and safety representatives were found to primarily consult their production supervisors in preference to their trade-union representatives. This follow-up article presents production supervisor perspectives on the RRDW. The study demonstrates how, for mineworkers, the two distinct communication subsystems constrain, rather than facilitate, implementation of the RRDW.
Comparison of the clinical effectiveness of Class IV Laser therapy and therapeutic ultrasound in patients with chronic neck pain: a randomized controlled trial
Authors: Shrestha Diggaj , Sharma Sunita
Published: June 2024

INTRODUCTION: Chronic neck pain (CNP) is a common musculoskeletal problem that affects a large proportion of the population and lasts longer than three months. It has a high cost in terms of life, disability, and healthcare. Several modalities have effectively provided immediate and long-term relief for CNP; however, the comparative clinical effectiveness of these modalities is limited. OBJECTIVES: The study aimed to determine the clinical effectiveness of Class IV Laser therapy and Therapeutic Ultrasound (TUS) in patients with CNP. METHODS AND MATERIALS: Forty-four patients with CNP of both genders were recruited from an age range of 20–45 years from the Department of Musculoskeletal Physiotherapy of Maharishi Markandeshwar Institute of Physiotherapy, MM(DU), Ambala, India. They were divided into two groups at random: the LASER group A (n = 22) and the TUS group B (n = 22). The intervention duration was 2 weeks with 6 treatment sessions. Pre- and post-treatment outcome measures were assessed with the Visual Analog Scale (VAS), Algometer, Goniometer, and Neck Disability Index (NDI) questionnaires at baseline and after 2 weeks of intervention. The LASER group received a target dose of 10 joules per cm2 at a power of 10 watts, with a continuous dosage frequency. The TUS group underwent a continuous mode ultrasound (3 MHz, 1 W/cm2) for 6 minutes. The Shapiro-Wilk test was used to assess the normality of the data. For parametric and non-parametric data analysis within the group, the paired t-test and Wilcoxon signed rank were used. The independent t-test and Mann-U Whitney test were used for the group comparison of parametric and non-parametric data, respectively. RESULTS: In both groups, there was a significant improvement in all the outcome measures (p<0.001). There was a statistically significant difference between the two interventions in VAS, Pain Pressure Threshold (PPT), and NDI (p<0.05). CONCLUSION: Class IV Laser therapy is clinically more effective than therapeutic ultrasound in treating patients with chronic neck pain.