bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemanfaatan ChatGPT untuk Pengotimalan Copywriting pada Madaris Jakarta Islamic Center
Authors: Prasetyo Johan Hendri , Sarasati Fajar , Mazia Lia , Astuti Widi
Published: April 2024

Adanya disrupsi digital dan disrupsi milenial di Indonesia berdampak pada persaingan pada seluruh sektor industri baik industri komersial maupun non-komersial, tidak terkecuali Majelis Remaja dan Pemuda Islam (Madaris) Jakarta Islamic Centre. Dengan perkembangan digital yang semakin massif tersebut, Madaris JIC harus mampu menyesuaikan diri untuk mengembangkan perekonomian bagi organisasi dan para anggotanya. Permasalahan yang di hadapi oleh Madaris JIC saat ini adalah adanya kesulitan yang dialami Madaris JIC dalam melakukan pemberdayaan dan meningkatkan perekonomian organisasi maupun anggotanya, terutama dengan minimnya pengalaman dalam memasarkan produk serta pesan iklan yang kurang menarik. Hal tersebut tentu saja menjadi permasalahan yang harus segera di atasi, salah satunya dengan pelatihan pemanfaatan ChatGPT untuk mengoptimalkan copywriting di kalangan organisasi dan anggotanya. Oleh karena itu, Dosen dan Mahasiswa Program Studi Bisnis Digital mengadakan pengabdian masyarakat dengan tujuan membantu Remaja Masjid Jakarta Islamic Centre dalam memberdayakan ekonomi bagi organisasi dan anggotanya
Pelatihan Pembuatan Pupuk Organik Eceng Gondok sebagai Pemanfaatan Tanaman Gulma di Desa Telukbango Kabupaten Karawang
Authors: Nurhanifah Afifa , Alamsyah Vikram , Sadidan Ikhwanussafa
Published: April 2024

Eceng gondok menjadi salah satu tanaman gulma atau tumbuhan pengganggu yang banyak tumbuh di Desa Telukbango, Kecamatan Batujaya, Karawang. Tujuan dari kegiatan pengabdian masyarakat ini yang beriringan dengan program Kuliah Kerja Nyata Mahasiswa Universitas Singaperbangsa Karawang yaitu meningkatkan pengetahuan dan wawasan masyarakat Desa Telukbango terhadap proses pemanfaatan tanaman eceng gondok. Eceng gondok dimanfaatkan sebagai bahan dasar pembuatan pupuk organik karena jumlah yang sangat banyak dan berpotensi menjadi limbah yang menghambat saluran irigasi pertanian. Pelatihan pembuatan pupuk organik eceng gondok dilakukan dengan metode ceramah, menyebarkan selebaran panduan tahapan pembuatan pupuk organik eceng gondok, dan praktik bersama pembuatan pupuk. Hasil kegiatan pengabdian masyarakat ini yaitu masyarakat Desa Telukbango khususnya para petani memahami pemanfaatan eceng gondok serta proses pembuatan pupuk dari eceng gondok yang selama ini hanya berpotensi sebagai limbah. Para petani dan masyarakat yang hadir menyambut antusias terhadap pemanfaatan eceng gondok menjadi pupuk organik, yang didukung oleh segenap jajaran aparat Desa Telukbango.
EL USO DE LAS TICS EN EL FORTALECIMIENTO DEL INGLÉS COMO LENGUA EXTRANJERA EN ESTUDIANTES DE GRADO QUINTO DE PRIMARIA
Authors: Luz Enith Moreno  , Leidy Constanza Bautista Moreno
Published: April 2024

El  presente estudio tuvo como objetivo la creación de una página web, con el fin de fortalecer las habilidades de lectura y escritura en el inglés en los estudiantes de grado quinto de primaria de la Institución Educativa la Cabaña sede el Diamante, se realizó bajo el enfoque cualitativo y con el método Investigación acción participativa (IAP). En primera instancia, se aplicó una prueba diagnóstica de entrada, que permitió conocer previamente que los estudiantes presentaban bajo conocimiento en vocabulario, reglas gramaticales, entre otras, se pudo catalogar como una de las causas por la que los educandos estaban presentando bajo nivel en las habilidades de lectura y escritura, causando en general, bajo desempeño en el área de inglés. Posteriormente, con base a dichos resultados se identificaron los temas a fortalecer, dando de este modo, lugar a la creación de recursos educativos digitales (RED) que fueron integrados en la página web e implementados en el aula; finalmente, se aplicó una prueba diagnóstica de salida que permitió comparar el avance de los estudiantes en el inglés como lengua extranjera y el uso que daban a las TIC para el aprendizaje de la misma. De ese modo, se pudo confirmar que son varios los factores que influyen a la hora de aprender un nuevo idioma en el aula de clase, entre ellos se encuentran. Según los resultados, aunque los docentes son conscientes de la importancia de las TIC no realizan la implementación pertinente de la misma, dejando de lado el aporte que genera al utilizarlo como medio didáctico a la hora de aprender el inglés como lengua extranjera. La investigación permitió determinar que es imprescindible que los docentes se capaciten para adquirir habilidades a la hora de utilizar las TIC en el desarrollo de sus clases.
ESTRATEGIAS PARA EL APRENDIZAJE DE LAS FUNCIONES ALGEBRAICAS EN LOS ESTUDIANTES DE CÁLCULO DIFERENCIAL
Authors: Amparo María Mejía
Published: April 2024

La presente investigación tuvo como objetivo general diseñar estrategias para el aprendizaje de las funciones algebraicas en los estudiantes de cálculo diferencial de Ingeniería Electromecánica de la Universidad Francisco de Paula Santander, ubicada en San José de Cúcuta. Metodológicamente se sustentó en un enfoque cuantitativo, bajo una investigación descriptiva, diseño de campo, no experimental de tipo transversal. La población constó de 120 estudiantes y seis docentes, a quienes se les aplicó una encuesta tipo cuestionario de 38 y 35 ítems, en escala tipo Likert, validados mediante la técnica juicio de expertos y se calculó su consistencia interna mediante el alfa de Cronbach obteniéndose valores de muy alta confiabilidad: 0.81 y 0.96. Para el análisis de los datos se apoyó en las medidas de tendencia central. Entre los hallazgos encontrados se obtuvo que los estudiantes hacen uso moderado de estrategias cognitiva, hay una baja presencia de estrategias metacognitivas y de apoyo para el aprendizaje de las funciones algebraica. Asimismo, los estudiantes consideran que los docentes hacen uso moderado de estrategias pre-instruccionales, coinstruccionales y posinstruccionales, que no es compartido por los docentes. Pero ambos grupos están identificados con el uso de software matemático y aulas virtuales para el aprendizaje de las funciones algebraicas.
PRÁCTICAS PEDAGÓGICAS EN LA FORMACIÓN POR COMPETENCIAS EN EL ÁREA DE CIENCIAS NATURALES Y EDUCACIÓN AMBIENTAL EN LA EDUCACIÓN BÁSICA SECUNDARIA Y MEDIA
Authors: Rafael Ordoñez Ortega
Published: April 2024

La educación en la actualidad requiere de nuevos recursos que le permite a los docentes buscar el camino ideal para una enseñanza efectiva, es así que dentro del área de ciencias naturales y educación ambiental es pertinente asumir nuevos retos y desafíos con la intención de contribuir al mejoramiento de los procesos de enseñanza y aprendizaje; razón que conlleva plantear el siguiente objetivo general: generar constructos teóricos sobre las practicas pedagógicas en la formación por competencias en el área de ciencias naturales y educación ambiental en la educación básica secundaria, de la Institución Educativa Integrado Petrolea, Municipio De Tibú, Departamento Norte De Santander – Colombia. La metodología empleada se encuentra definida por la investigación de enfoque cualitativo apoyada en el paradigma interpretativo a través del método hermenéutico. La técnica de análisis de la información se enmarca en lo que plantea el círculo hermenéutico, lo cual conlleva a brindar aportes significativos que se convierten en un recurso instruccional que va en función del mejoramiento del rendimiento académico de los estudiantes en el área de ciencias naturales lo que permite establecer las bases para una educación efectiva de gran calidad. Lo cual lleva a concluir que las prácticas pedagógicas en la formación de las competencias en el área de ciencias naturales son fuente esencial para que desde las aulas de clase y del rol de los docentes se logre dar pasos sólidos en función de una educación de calidad.
CONSTRUCTOS TEÓRICOS SOBRE LA ENSEÑANZA DE LA GEOMETRÍA EN LA EDUCACIÓN BÁSICA PRIMARIA EN EL SISTEMA EDUCATIVO COLOMBIANO
Authors: Yeraly Yibelly Noguera Torres
Published: April 2024

La investigación que se presenta tiene como objetivo general: analizar los constructos teóricos como factor de calidad en la convivencia escolar desde la perspectiva de las representaciones sociales de los actores educativos, aplicado en la Unidad Educativa Bolivariana “La Victoria”, Rubio, Municipio Junín, Estado Táchira. Se suma a ello objetivos específicos como: develar las necesidades, expectativas e intereses de los actores educativos en relación con el factor de calidad en la convivencia escolar. Así mismo se presenta el objetivo específico que dice: analizar el impacto del conflicto escolar en la comunidad educativa desde la perspectiva de los actores educativos. Seguido de otro objetivo específico que señala: reflexionar sobre las causas y efectos del conflicto escolar y sus implicaciones en el rendimiento académico de los estudiantes. El cuarto objetivo específico plantea: estructurar los componentes teórico-procedimentales de los constructos teóricos como factor de calidad en la convivencia escolar desde la perspectiva de las representaciones sociales de los actores educativos. El trabajo se centra en el enfoque cualitativo, bajo el paradigma interpretativo. Apoyado en la técnica de análisis de contenido, lo cual emerge de una reflexión teórica sobre la información encontrada en relación con la convivencia escolar para de esa manera establecer las bases de los constructos teóricos en función de la calidad en la convivencia escolar.
CONSTRUCTOS TEÓRICOS SOBRE LA ENSEÑANZA DE LA GEOMETRÍA EN LA EDUCACIÓN BÁSICA PRIMARIA EN EL SISTEMA EDUCATIVO COLOMBIANO
Authors: Francy Alejandra Cruz Mahecha
Published: April 2024

La educación, hoy en día representa el nivel cultural de una nación y es por ello que se hace pertinente ahondar en todas las aristas que se desprenden de ella para que de alguna manera se puedan generar acciones que vayan a respaldar la necesidad de repensar lo existe para generar nuevas maneras de enseñar buscando con ello éxito en los diferentes procesos y a la vez calidad en el rendimiento académico de los estudiantes de educación básica primaria con respecto a los temas de la geometría. Es así que emerge en presente objetivo general: establecer constructos teóricos sobre la enseñanza de la geometría en la educación básica primaria en el sistema educativo colombiano. La metodología empleada se refleja en el enfoque cualitativo, bajo los preceptos del paradigma interpretativo a través del método hermenéutico; apoyado en la técnica de análisis documental; lo cual conduce a un análisis desde lo que es el rendimiento estudiantil de los estudiantes en las pruebas PISA que por razones múltiples no ha dejado en un buen sitial el ranking de calificaciones de los estudiantes con respecto a sus semejantes con otros países. Razón que conduce a repensar que está sucediendo con el diseño curricular, con las estrategias pedagógicas o los recursos instrucciones que no han sido efectivo en el fortalecimiento de las competencias matemáticas específicamente en la geometría. Por lo tanto, se logró concluir que los libro texto, guías y medios de enseñanza también se deben revisar y ofrecer a los docentes algunos constructos enfocados en las tendencias e innovaciones que en la actualidad permean el sistema educativo.
LA ESTADÍSTICA COMO CONTENIDO FUNDAMENTAL EN EL ÁREA DE MATEMÁTICAS
Authors: Celgar Arnaldo Millán
Published: April 2024

Una de las áreas obligatorias y de gran importancia para la formación del os estudiantes en cualquier nivel es las matemáticas una de las ciencias que se encarga de estudiar las propiedades de los números logrando así conocer la relación que existe entre ellos, dentro de la misma se encuentra como un contenido primordial la estadística la cual se basa en el cálculo de las probabilidades y que permite que se llegue a un resultado a través de una conclusión numérica, es por esta razón que se plantea en este artículo el siguiente objetivo general; comprender la estadística como contenido fundamental en el área de matemáticas, para lograr el mismo el estudio se enfoca en la metodología, seleccionando el paradigma interpretativo, ya que se busca ver la realidad desde una perspectiva más profunda, de la misma manera se enfoca en una investigación de carácter cualitativo, buscando desde el contexto palpar la realidad del objeto de estudio, recogiendo toda la información desde una entrevista establecida y la observación directa, el método del presente artículo recae en la hermenéutica, por medio de un estudio documental, para lograr así obtener la información necesario a y lograr el objetivo propuesto para este estudio, obteniendo como conclusión la comprensión y valorización del a esta dística como contenido primordial en las matemáticas, ya que permite así que los estudiantes desarrollen competencias necesarias para una formación integral.
Integrated Approach for Screening Groundnut Genotypes and Unveiling Morphological and Biochemical Factors Associated with Resistance to Thrips, Scirtothrips dorsalis Hood
Authors: Madhuri Burjikindi , Sugandi Rohini , Kandakoor Subhash B. , Yenagi Basavaraj S. , Bharghavi Kolli
Published: April 2024

Thrips is an important sucking insect pest and are the major problem in the groundnut. The pressure from thrips is higher in the summer. One species of thrips i.e., Scirtothrips dorsalis Hood was reported in the present investigation. To minimize crop losses, it is important to efficiently manage thrips, Scirtothrips dorsalis Hood. Finding the source of resistance is one strategy to reduce yield losses. In the summers of 2020 and 2021, forty-four groundnut varieties were screened in the field to determine their resistance to thrips occurrence. Nineteen genotypes were chosen for additional research, including host preference and oviposition preference tests in greenhouse conditions and host plant resistance studies, based on preliminary screening studies conducted at the field level in 2020 and 2021. None of the genotypes were totally free from thrips damage. Nonetheless, three genotypes (Dh-256, RST-1-2020-12, and INS-1-2020-11) were classified as resistant. Ten genotypes were very vulnerable, 14 were susceptible, and 17 were somewhat resistant. The biochemical and morphological examination results showed that resistance against thrips was conferred by increased levels of phenols, tannins, trichome density, and leaf colour.
Fluktuasi Nilai IHSG: Dampak Kondisi Inflasi Tahun 2023 di Indonesia
Authors: Yandes Jufri , Destiana Destiana , Azka Raga Ridha , Jasrial Jasrial , Fajar Suryo Antoro Aji , Putri Pertiwi Husna
Published: April 2024

Dalam mengarungi alur kehidupan, investasi menjadi pilar utama untuk memastikan kelangsungan keuangan di masa mendatang. Penelitian ini menggali kemungkinan pengaruh kondisi inflasi tahun 2023 terhadap fluktuasi nilai IHSG dari Januari hingga Desember. Data time series IHSG selama 12 bulan digunakan dari sumber Yahoo Finance, dan analisis regresi linier melalui EViews digunakan untuk menguji hipotesis dengan uji t, dan data dari Bank Indonesia untuk kondisi inflasi. Hasil penelitian menarik menyatakan bahwa fluktuasi IHSG tidak dapat dipengaruhi oleh kondisi inflasi tahun 2023, khususnya pada rentang waktu yang diteliti. Ini memberi gambaran bahwa faktor-faktor lain mungkin lebih dominan dalam menentukan pergerakan IHSG selama periode tersebut. Pentingnya penelitian ini bukan hanya untuk memahami dinamika pasar modal, tetapi juga sebagai panduan bagi investor dalam membuat keputusan investasi yang lebih terarah. Namun, penelitian ini tidak terlepas dari keterbatasan, seperti keterbatasan data waktu yang tersedia dan generalisasi hasil hanya pada rentang waktu tertentu. Harapannya, penelitian mendatang akan mengidentifikasi dan memperbaiki keterbatasan ini untuk mendapatkan pemahaman yang lebih komprehensif tentang hubungan antara kondisi ekonomi khususnya mengenai inflasi, IHSG, dan pasar modal. Dengan demikian, investor di masa depan dapat menghadapi perubahan kondisi ekonomi dengan lebih percaya diri dan strategis.
Research on Complementary Filtered Attitude Solution Method for Quadcopter Based on Double Filter Preprocessing
Authors: ZHANG Linlin , ZHOU Haoyu , LIANG Jianshu , XIE Meng , YANG Guang
Published: April 2024

In the attitude calculation process of quadrotor, the traditional pre-filtering method has degraded the attitude solving accuracy due to incomplete denoising of accelerometer and gyroscope measurements. Therefore, a complementary filtered attitude solution method based on double filter pre-processing is proposed to address this problem. First, the signal decomposition, hard threshold denoising, and signal reconstruction of the accelerometer and gyroscope acquired data are performed using the Haar real-time wavelet filtering algorithm. The reconstructed signal is then filtered by the infinite impulse response ( IIR ) low-pass filtering algorithm to remove the residual high-frequency noise and complete the dual filtering preprocessing. Next, the gyroscope data is corrected with accelerometer data according to the complementary filtering algorithm. Finally, the corrected data are used to solve the quaternion and thus the attitude angle by combining the Longacurta method. The results show that the dual filtering preprocessing method can further reduce the noise in the measurements of accelerometer and gyroscope. The attitude angle results calculated by the proposed method in the static and dynamic hovering states of the four-rotor aircraft have a small degree of dispersion, which can effectively improve the accuracy of attitude calculation.
Study on the Thermal Sensitivity of Anisotropic Thin Sheets: Application to Hot Bulge Tests
Authors: ELADEB Aboulbaba , NASRI Mohamed Toumi , BECHEIKH Nidhal , GHAZOUANI Nejib , TASHKANDI Mohammed A.
Published: April 2024

This article presents a study on the thermal sensitivity of anisotropic thin sheets, focusing specifically on their behavior during hot bulge tests. Anisotropic materials exhibit different mechanical properties in different directions, and understanding their response to thermal loading is crucial for various engineering applications.

The experimental investigation involves subjecting thin sheets of anisotropic materials to controlled thermal conditions and measuring their response. The hot bulge test, a well-established method, is employed to analyze the behavior of the sheets under elevated temperatures. This test involves applying a controlled internal pressure to a heated circular and elliptical specimen, causing it to deform and form a bulge.

Through this study, the thermal sensitivity of anisotropic thin sheets is characterized by analyzing the bulge height, bulge profile, and strain distribution. The influence of various factors, such as temperature, material anisotropy, and loading rate, is examined to understand their effects on the sheet's response.

Experimental results reveal significant variations in the thermal sensitivity of anisotropic thin sheets, depending on the material's orientation and temperature. The study demonstrates that certain orientations exhibit greater sensitivity to thermal loading, leading to distinct bulge profiles and strain distributions.

Furthermore, numerical simulations are conducted using finite element analysis to validate and complement the experimental findings. The simulation models incorporate the anisotropic material properties and the thermal boundary conditions, enabling a comprehensive understanding of the thermal sensitivity behavior observed experimentally.

The outcomes of this study provide valuable insights into the thermal behavior of anisotropic thin sheets, particularly in the context of hot bulge tests. The findings contribute to the knowledge base of material characterization and can aid in the design and optimization of structures and components subjected to thermal loading, where anisotropic materials are involved.
A Fixed-Bed Column Sorption: Breakthrough Curves Modeling
Authors: A. Abin-Bazaine Andrés , A. Olmos-Marquez Mario , Campos-Trujillo Alfredo
Published: April 2024

Global attention has increasingly focused on environmental pollution due to its widespread and devastating impact. The urgency of addressing climate change has propelled it to the forefront of governmental agendas worldwide, emphasizing the need for actions to secure a pollution-free future. Pollution treatment methods have consequently gained global significance, with adsorption emerging as a particularly relevant approach, especially in developing economies. Adsorption proves to be a cost-effective, safe, efficient, and easily manageable method that can utilize low-cost or waste materials. In designing treatment systems based on adsorption, batch tests are crucial, employing adsorption isotherms such as Langmuir and Freundlich to understand the phenomenon. While equilibrium points are essential in some situations, continuous processes benefit from column implementations, where a fundamental understanding of breakthrough curves becomes pivotal. Various adsorption kinetic models, such as the Thomas model, Adams–Bohart model, Yoon–Nelson model, and bed-depth/service time (BDST) model, explain and determine breakthrough curves. The assessment of these models for compatibility with experimental data and model-generated data is essential. Criteria such as Mean Relative Error (MRE) and Normalized Relative Mean Square Error (NRMSE) are commonly employed to objectively select the most suitable model for a given scenario.
Care of Post-Operative Altered Bowel Function in Colorectal Cancer Patients
Authors: Lu Ling-Chun
Published: April 2024

Rectal cancer patients with postoperative altered bowel function have poorer quality of life than colon rectal cancer patients with it. The altered bowel function symptoms were named low anterior resection syndrome. Mechanisms of these symptoms associated with removing rectum and receptors on its internal wall, creating neorectum, and destroying pelvic neuro-plexus by analsaving surgery. Due to the low anterior resection syndrome, patients suffered from physical, psychological and social impacts on quality of life. Three options are used to treat low anterior resection syndrome, including self-care strategies, clinician-initiated interventions, and creating a permanent stoma. The self-care strategies contain diet modification, lifestyle changes, and spiritual sublimation. The clinician-initiated interventions include prescribed medication, trans-anal irrigation, pelvic floor rehabilitation, neuromodulation, and so on. Creating a permanent stoma is the eventual choice due to anastomotic restriction. Altered bowel function may follow postoperative rectal cancer patients for whole life; however, flexibly using these care strategies may help them adjust.
Metal Organic Frameworks Used as Antibiotic Removal Agents in Water
Authors: Martell Mendoza Miguel , Alberto Méndez Cuesta Carlos , Angel Zavala Sánchez Miguel , Cuauhtemoc Pérez Montiel Erick , Mata Berbudez Alfonso , Pérez González Cuauhtemoc
Published: April 2024

Currently, there are approximately 250 antibiotics registered for use in human and veterinary medicine worldwide, which, as a result of inadequate management and poor disposal of waste, among other bad practices in their management, are more common in wastewater; this situation has begun to attract more attention and be an interesting topic for the proposal of solutions. In the search for options to solve this problem, structured materials are being actively studied; one material that has received significant attention is the metal organic framework (MOF) type. The use of MOFs with various topologies and characteristics are demonstrating great effectiveness in the elimination of different types of contaminants from water, such as medications, such as anti-inflammatories, antibiotics, explosives, and heavy metals. Different antibiotics are used as models in these studies, from which it follows that the nature of the drugs that can be eliminated from effluents is very varied, which allows us to see that it can be an interesting option. Another objective pursued by these studies is to seek to establish the number of cycles in which these materials can be used to carry out the capture of drugs, as well as the type of kinetics that follow the adsorption of these materials in the MOFs.
Hypercholesterolemia Increases the Risk of Colorectal Cancer by a Tet-1-Dependent HSC-Autonomous Mechanism
Authors: Messina Louis , Tie Guodong
Published: April 2024

The annual, age-standardized colorectal cancer (CRC) incidence rate has decreased by 46% from its peak in 1985. However, this long-standing decline in cases of CRC slowed due mainly to an increase in incidence in individuals younger than 50 years of age. For those less than 50 years of age, CRC is the leading cause of cancer deaths in men and the second in women. At least half of all cases of young-onset CRC are linked to lifestyle risk factors, including obesity. Hypercholesterolemia, a common metabolic disorder in obese people, has been shown to increase the risk of colorectal cancer, but the mechanism is unknown. We will show that hypercholesterolemia increases the incidence and pathological severity of colorectal cancer by inducing an oxidant stress-dependent hematopoietic stem cell-autonomous mechanism. The oxidized-LDL increase in HSC oxidant stress initiates a signaling pathway that culminates in the increased expression of miR101c that downregulates Tet1. This downregulation of Tet1 reduces the expression of the genes critical to the production and cytotoxicity of natural killer T cells and T cells, thereby impairing cancer immunosurveillance against colorectal cancer. This reveals a novel mechanism where a metabolic disorder induces epigenetic reprogramming of natural killer T cells and γδT gene expression within hematopoietic stem cells.
Autologous Adipose Tissue Stem Cell-Derived Terminally Differentiated Retinal Pigment Epithelium Monolayer on a Biocompatible Scaffold, to Restore Vision in Age-Related Macular Degeneration Patients
Authors: Bouzianas Dimitrios
Published: April 2024

In Western countries, age-related macular degeneration (AMD) is the common cause of central visual loss in the elderly leading to gradual blindness. Studies implicate the retinal pigment epithelium (RPE) as an important player in AMD pathogenesis, as progressive loss of RPE cells and photoreceptors lead to poor visual acuity. Several strategies aim to prevent the RPE degeneration by saving the damaged retinal cells or replacing them. Cell rescue provides retinal cells with trophic or immunomodulatory factors, whereas cell replacement aims to repair and regenerate neuroretina providing new cells. Currently, a major limitation is cell loss from subretinal injections of bolus cell suspensions. The most promising studies focus on tissue transplantation or RPE cell patches hosted on implantable scaffolds made of advanced biomaterials. The latter support the development of artificial 3D retinal constructs improving functional integration capacity and increasing the survival of implanted cells into the damaged retina. However, there is no consensus on the optimal RPE source, delivery strategy, cell dose and animal model for testing. This chapter aims to improve the efficacy of RPE grafting suggesting an optimal cell source, an efficient delivery method, and the topography of retina damage as a determining factor to calculate the effective therapeutic dose.
Impact of Microplastic in Mexican Coastal Areas Using Mussels (Mytilus spp.) as Biomonitors
Authors: Berenice Bonilla Martínez Ivonne , Alberto Mendoza Pérez Jorge , Santos Echeandía Juan , Rose Kozak Eva , Garibay Febles Vicente , Alejandro Fregoso Aguilar Tomás , Godínez Domínguez Enrique , Olivos Ortiz Aramis
Published: April 2024

Microplastics (MP) are plastic fragments smaller than 5 mm found in water columns and sediments, posing a threat to marine life due to their toxicological potential for the absorption and release of harmful compounds such as heavy metals. Mussels exhibit high filtration rates with the ability to bioaccumulate microplastics and are considered bioindicators of environmental contamination. The present study aims to evaluate the impact of microplastics in different geographical areas to identify their effects on ecosystems and potential damage to human health, focusing on the bioaccumulation capacity of MP in mussels. Samples of water, sediment, and mussels (Mytilus) from the Central Mexican Pacific were analyzed using optical microscopy and contamination indices. The levels of heavy metals detected at the sampling sites suggest low contamination, according to the Heavy Metal Evaluation Index (HEI). In Juluapan Lagoon, 93% of the MP particles found were fibers, with similar results in Barra de Navidad (75%). In Puerto Interior, Laguna Valle de Garzas, and Juluapan Lagoon, fibers accounted for 100% of the identified MP in water. The concentration of MP in water reached up to 7 MP/L, and 13 MP/mussel in Barra de Navidad. The presence of associated contaminants and MP suggests potential harmful effects on environmental health due to the high bioaccumulation of microplastics in mussels.
Evaluation of Antifungal Effect of Allium jesdianum Bacterial Endophytes on Rhizopus stolonifer, Penicillium, Cladosporium, and Trichophyton mentagrophytes
Authors: Ameri Reza , Shahrokh Shahraki Somayeh
Published: April 2024

: Antimicrobial resistance (AMR) is the ability of microbes to survive and grow in the presence of antimicrobial drugs. Bacterial endophytes, which reside within plants, can promote plant growth and other essential activities. Endophytes have the potential to produce novel and unique products for use in modern medicine, agriculture, and industry. They may hold the key to combating drug-resistant strains by providing new antimicrobial compounds, potentially leading to the development of new medications. In this study, bacterial endophytes of Allium jesdianum were extracted and characterized. The antifungal effect of these endophytes on Rhizopus stolonifer, Penicillium, Cladosporium, and Trichophyton mentagrophytes was evaluated. Various parts of the plant were used to isolate ten bacterial endophytes to assess their antifungal properties. Universal eubacterial primers were used to amplify a 1500 bp region of the 16S rRNA gene. The resulting partial nucleotide sequences were compared with sequences available from the National Center for Biotechnology Information (NCBI) and EzBioCloud Database. Subsequent comparisons determined their similarity. Each isolated endophyte was cultured with equal amounts of R. stolonifer, Penicillium, Cladosporium, and T. mentagrophytes. This study measured the level of antagonism by assessing the extent of potential interactions. Ten bacterial endophytes, primarily cocci and bacilli, were extracted from different parts of A. jesdianum. The isolates were identified as Staphylococcus warneri AJB1, Staphylococcus succinus AJB2, Pseudomonas thivervalensis AJB3, Bacillus subtilis AJB4, Acinetobacter lwoffii AJB5, and Pantoea brenneri AJB6. AJB1 and AJB3 showed no antagonistic activity. AJB2, AJB5, and AJB6 displayed antagonistic action against R. stolonifer. Only AJB4 showed strong antagonistic activity against Penicillium. Further research is necessary to determine whether these endophytes possess antibiotic activity and can be used for food preservation.
Study of the translation of Chinese folk phrases into English (based on diplomatic discourse)
Authors: Сунь И.
Published: April 2024

целью данного исследования является анализ перевода китайских фольклорных фраз на английский язык с учетом их использования в дипломатическом дискурсе. В ходе работы производится систематизация и классификация таких фраз с последующим анализом их трансформации при переводе. Научная новизна исследования заключается в выявлении специфических стратегий и техник перевода культурно-значимых выражений в контексте дипломатических коммуникаций, что позволяет расширить понимание механизмов культурного обмена и взаимодействия в международном дипломатическом общении. Результаты исследования представлены в виде аналитического обзора ключевых аспектов перевода китайских фольклорных фраз на английский язык в дипломатическом контексте, а также разработки рекомендаций по эффективному использованию переводных стратегий для достижения максимальной коммуникативной ясности и эффективности в обмене между культурами.

the purpose of this study is to analyze the translation of Chinese folk phrases into English, taking into account their use in diplomatic discourse. In the course of the work, such phrases are systematized and classified, followed by an analysis of their transformation during translation. The scientific novelty of the study lies in the identification of specific strategies and techniques for translating culturally significant expressions in the context of diplomatic communications, which allows us to expand our understanding of the mechanisms of cultural exchange and interaction in international diplomatic communication. The results of the study are presented in the form of an analytical overview of key aspects of translating Chinese folk phrases into English in a diplomatic context, as well as developing recommendations for the effective use of translation strategies to achieve maximum communicative clarity and efficiency in exchanges between cultures.
Structural and semantic types of comparisons in the Ossetian language
Authors: Бетеева Ф.Г.
Published: April 2024

сравнение – одно из самых употребляемых средств выразительности речи. Лингвопрагматический и стилистический потенциал сравнения в устной и письменной речи огромен, а способы его выражения – разнообразны, что является причиной интереса исследователей к данной лингвистической единице. Статья посвящена сравнению как выразительному средству в современном осетинском языке. Целью данной статьи является анализ структурных и семантических типов сравнения в современном осетинском языке. Были произведены сбор и анализ теоретической базы по данной теме, сбор и систематизация языкового материала, выделение основных структурных и семантических типов сравнения в современном осетинском языке и обоснование этого выделения. Актуальность темы обусловлена тем, что вопросы, связанные со сравнением как выразительным средством в целом и структурно-семантических особенностями сравнений в частности в современном осетинском языке на данный момент не изучены в достаточной мере. В связи с этим результаты работы могут быть использованы в преподавании современного осетинского языка на различных уровнях образования, а также при дальнейшем изучении других вопросов, связанных со сравнением как выразительным средством.

comparison is one of the most widely used means of expressive speech. The linguistic and stylistic potential of comparison in oral and written speech is huge, and the ways of its expression are diverse, which is the reason for the interest of researchers in this linguistic unit. The article is devoted to comparison as an expressive means in the modern Ossetian language. The purpose of this article is to analyze the structural and semantic types of comparison in the modern Ossetian language. The collection and analysis of the theoretical base on this topic, the collection and systematization of linguistic material, the identification of the main structural and semantic types of comparison in the modern Ossetian language and the justification of this allocation were carried out. The relevance of the topic is due to the fact that the issues related to comparison as an expressive means in general and the structural and semantic features of comparisons in particular in the modern Ossetian language have not been sufficiently studied at the moment. In this regard, the results of the work can be used in teaching modern Ossetian at various levels of education, as well as in further studying other issues related to comparison as an expressive means.
Key aspects of legal regulation state of financial control in modern Russia and abroad
Authors: Шелепова Е.Ю.
Published: April 2024

в все времена совместная работа органов государственного финансового контроля из разных стран мира играет огромное значение для поиска эффективных механизмов осуществления государственного финансового контроля. Выработка единых задач, методик, принципов деятельности способствует унификации и совершенствованию государственного финансового контроля. В статье рассмотрены ключевые аспекты правового регулирования государственного финансового контроля в отечественной и зарубежной практике. Раскрыты общие черты и различия в подходах по выработке нормативной правовой основы регулирования государственного финансового контроля, а также обозначены актуальные аспекты формирования нормативно-правой базы внутреннего и внешнего государственного финансового контроля в Российской Федерации и зарубежом.

at all times, the joint work of state financial control bodies from around the world has been of great importance for the search for effective mechanisms for the implementation of state financial control. The development of common tasks, methods, and principles of activity contributes to the unification and improvement of state financial control. The article examines the key aspects of the legal regulation of state financial control in domestic and foreign practice. The author reveals common features and differences in approaches to the development of a regulatory legal framework for regulating state financial control, as well as identifies relevant aspects of the formation of a regulatory framework for internal and external state financial control in the Russian Federation and abroad.
Judicial protection in case of banking transactions using a duplicate SIM card
Authors: Юсупов Д.Д.
Published: April 2024

современный человек привык быть мобильным, быстрый обмен данными и бесконечный поток информации стали нормой повседневной жизни, вследствие чего многие услуги перешли в онлайн. Исключением не стал и банковский сектор. Так у каждого банка разработано свое банковское приложение, вмещающее в себя не только весь спектр банковских услуг, но и побочные продукты, такие как: бухгалтерские услуги, юридические консультации, брокерские услуги. Банковские приложения из года в год становятся только популярнее, и некоторые банки вовсе отказались от формата офиса в пользу онлайн формат. Вместе с тем, отсутствие человека при совершении сделки ставит вопрос о его идентификации, из-за чего, как правило, приложение привязывается к номеру телефона (сим-карте). Однако, такой вариант идентификации не исключает факт мошеннических действий, вследствие чего одним из популярных способов неправомерного завладения учетной записи приложения является доступ к приложению с помощью дубликата сим-карты.

modern people are used to being mobile, fast data exchange and an endless stream of information have become the norm of everyday life, as a result of which many services have moved online. The banking sector was no exception. So each bank has developed its own banking application, which includes not only the entire range of banking services, but also by-products such as accounting services, legal advice, brokerage services. Banking applications are only becoming more popular from year to year, and some banks have completely abandoned the office format in favor of the online format. At the same time, the absence of a person during the transaction raises the question of his identification, which is why, as a rule, the application is linked to a phone number (SIM card). However, this identification option does not exclude the fact of fraudulent actions, as a result of which one of the popular ways to illegally take over an application account is to access the application using a duplicate SIM card.
Guidelines to optimise the sensory detection of 2,4,6-trichloroanisole in neutral spirit and whisky
Authors: Baxter Irene , Réveillé Augustin , Conner John
Published: April 2024

Why was the work done: Guidelines are required to optimise the sensory detection of musty/stale taints in alcoholic spirits caused by 2,4,6-trichloroanisole. Early detection of the taint is necessary as the low sensory threshold can result in significant quality issues and masking the musty/stale off-note through blending is difficult.
How was the work done: The standard industry practice for ‘nosing’ is to dilute samples of spirit to 20% ABV to prevent sensory fatigue.  It is not known if 20% ABV is the optimal concentration for detecting 2,4,6-trichloroanisole. In this study, the effects of ethanol concentration on the detection of the taint were evaluated using a sensory panel and gas chromatography-mass spectroscopy. The efficacy of nosing versus tasting to detect 2,4,6-trichloroanisole was investigated at different dilutions of distilled spirits. Further, the stability of this off-note at 20% ABV was determined to assess if the taint could be detected by nosing over a working day. Finally, the serving temperature of the sample was assessed in the sensory perception of the taint.
What are the main findings: The recommendations to optimise the sensory detection of 2,4,6-trichloroanisole in spirit samples are (i) nose samples at 20% ABV, (ii) as soon as possible after dilution conduct sensory tests and (iii) chill the sample.
Why is the work important: The limits of detection for conventional solid phase microextraction with gas chromatography-mass spectroscopy are typically above the threshold of human perception. Therefore, the industry needs to maximise the detection by sensory panellists of contaminated whisky samples to ensure the product does not go to market so as to avoid any reputational damage.
Screening and Diagnosis of Rare Thalassemia Variants: Is Third-Generation Sequencing Enough?
Authors: Tang Haishen , Xiong Yi , Tang Jiaqi , Wang Xiaohong , Wang Ya , Huang Liping , Wang Runli , Wang Degang
Published: April 2024

Context.—

Rare thalassemia subtypes are often undiagnosed because conventional testing methods can only identify 23 common types of α- and β-thalassemia.

Objective.—

To assess a comprehensive approach for the screening and diagnosis of rare thalassemia.

Design.—

The study cohort included 72 individuals with suspected rare thalassemia variants. Screening was conducted by next-generation sequencing (NGS) combined with third-generation sequencing (TGS) and chromosomal microarray analysis (CMA)/copy number variation sequencing.

Results.—

Of the 72 individuals with suspected rare thalassemia, 49 had rare α- or β-gene variants. NGS combined with gap polymerase chain reaction detected a total of 42 cases, resulting in a positive detection rate of 58.3%. Additionally, 4 α-globin genetic deletions were identified by TGS, which increased the variant detection rate by 5.6%. Two samples with a microdeletion of chromosome 16 or 11 were detected by CMA, which increased the detection rate by 2.8%. For one sample, reanalysis of the NGS and TGS data confirmed the presence of the β41-42/βN and βN/βN mosaic. The HBB:c.315 + 2delT mutation was initially reported in Guangdong Province, China. Two HBB gene mutations (HBB:c.315 + 5G>C and HBB:c.295G>A) and 4 rare HBA gene deletions (–11.1, -α27.6, -α2.4, and -α21.9) were initially identified in the Zhonshan region. The hematologic phenotypes of all rare cases in this study were clarified.

Conclusions.—

Rare thalassemia variants are more common than previously thought. Despite advancements in TGS, there is still no foolproof method for detection of all types of thalassemia. Thus, a comprehensive approach is necessary for accurate screening and diagnosis of rare thalassemia variants.
Clinicopathologic Correlates of PIT1 and SF1-Multilineage Pituitary Neuroendocrine Tumors and the Diagnostic Utility of NKX2.2 Immunohistochemistry in Pituitary Pathology
Authors: Doğukan Fatih Mert , Karatay Hüseyin , Yüzkan Sabahattin , Burhan Şebnem , Erkan Buruç , Yılmaz-Özgüven Banu
Published: April 2024

Context.—

PIT1 and SF1-multilineage pituitary neuroendocrine tumors (PitNETs) have been defined since the classification of adenohypophysial tumors based on the PIT1, SF1, and TPIT transcription factors.

Objective.—

To describe the clinicopathologic features of PIT1 and SF1-multilineage PitNETs and to contribute to the pituitary pathology practice by questioning the expression of NKX2.2 in PitNETs.

Design.—

We reviewed 345 PitNETs and described the clinicopathologic features of 8 PIT1 and SF1-multilineage tumors. NKX2.2 positivity and staining pattern were compared to those of 45 PitNETs from the control group.

Results.—

PIT1 and SF1-multilineage PitNET patients had a mean age of 41.13 (range, 14–58 years) and a mean tumor diameter of 14.0 mm (range, 8–20 mm). The most common clinical presentation was acromegaly (6 of 8), and postoperative remission was achieved in all patients. On histomorphologic examination, a pseudopapillary pattern was seen in 5 of the tumors, either focally or diffusely. In addition to PIT1 and SF1, there was a diffuse staining with growth hormone and a predominantly perinuclear staining with cytokeratin 18. With NKX2.2, all multilineage tumors were positive, of which 5 were diffuse and 3 were focal. In the control group, 8 tumors (8 of 45) were positive, of which only 1 was diffuse and 7 were focal.

Conclusions.—

In conclusion, NKX2.2 is a transcription factor that can be used as an additional tool in pituitary pathology, and PIT1 and SF1-multilineage PitNETs are specific tumors that usually present with acromegaly, show signs of a nonaggressive clinical course, have a pseudopapillary histomorphology, and express NKX2.2.
Orta Koridor’un Dünya Politikasında ve Avrasya’da Artan Önemi
Authors: Kaya Emrah
Published: April 2024

Dünya siyasetinde artan gerilim, Soğuk Savaş’tan bu yana en yüksek seviyesindedir. Bu durum küresel boyutta güvensizliğe ve çeşitli bölgelerin istikrarsızlaşmasına neden olmaktadır. Ayrıca çeşitli ticaret ve taşımacılık güzergahlarını da olumsuz etkilemektedir. Bunun yanı sıra bölgesel boyutta da çeşitli dönüşümler yaşanmaktadır. Geniş Avrasya coğrafyasında yaşanan gelişmeler, dönüşüm sürecinin en önemli örnekleri arasındadır. Bu bağlamda çalışmada Orta Koridor ele alınacaktır. Küresel ve bölgesel siyasette yaşanan gelişmelerin Orta Koridor’un önemini nasıl etkilediği incelenecektir. Aynı zamanda Avrasya’daki dönüşüm ve Orta Koridor’un yarattığı fırsatlara değinilecektir.
Working with Graphs: Pre-training and Application
Authors: He Xuzeng
Published: April 2024

Latest findings in pre-training graphs and using them for link recommendation Author · Xuzeng He (

ORCID:

0009–0005–7317–7426) Introduction A graph, in short, is a description of items linked by relations, where the items of a graph are called nodes (or vertices) and their relations are called edges (or links). Examples of graphs can include social networks (e.g. Instagram) or knowledge graphs (e.g. Wikipedia). In Instagram
Introduction to APOC: Enhancing Neo4j Capabilities
Authors: Pi Wenyi
Published: April 2024

Neo4j APOC Library Use Case

Author

Wenyi Pi (

ORCID:

0009–0002–2884–277)

Introduction

In the realm of Neo4j, the APOC (Awesome Procedures on Cypher) library stands as a powerful tool. Previously, We have talked about the importance of APOC in optimising Cypher queries and improving query efficiency in our article Exploring Methods of Cypher Query Optimisations.
Mayo francés y España: impactos culturales y consecuencias políticas
Authors: Carrillo Linares Alberto
Published: April 2024

En este trabajo analizo el impacto real que los sucesos estudiantiles franceses de mayo de 1968 tuvieron sobre España. Estudiaré algunas de las vías de penetración de la información que permitió a los estudiantes españoles tener un conocimiento de lo que ocurria al margen de los canales oficiales y legales, que tampoco dejaron de informar: se visualizarán algunos de los contactos personales y orgánicos existentes antes y durante el "Mayo". Como hecho simbólico atenderé a la ocupación del Colegio de España en Paris durante el mes de mayo de 1968, en la efervescente Ciudad Internacional Universitaria, y sus sacudidas posteriores. Finalmente evaluaré a algunas de las consecuencias politicas concretas del Mayo del 68 para el Gobierno español. Se han utilizado para ello tanto fuentes orales, archivísticas (centros nacionales e internacionales), policiales, hemerográficas, carteles y fotografias.
Entre el compromiso, la internacionalización y la Historia Económica. Conversación con Gabriel Tortella
Authors: López Santiago M.
Published: April 2024

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