bluuebunny/crossref_metadata_2025 huggingface dataset:
Opioid-Free Using Ketamine versus Opioid-Sparing Anesthesia during the Intraoperative Period in Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial
Authors: Choi Hoon , Huh Jaewon , Kim Minju , Moon Seok Whan , Kim Kyung Soo , Hwang Wonjung
Published: August 2024

Opioids effectively manage perioperative pain but have numerous adverse effects. Opioid-free anesthesia (OFA) eliminates intraoperative opioid use; however, evidence for its use in video-assisted thoracoscopic surgery (VATS) is limited. This study assessed the effect of OFA using ketamine in VATS patients compared to opioid-sparing anesthesia (OSA). A total of 91 patients undergoing VATS lobectomy or segmentectomy were randomized to either the OFA group (ketamine) or the OSA group (remifentanil). The primary outcome was the quality of recovery (QoR) on postoperative day (POD) 1, measured with the QoR-40 questionnaire. Secondary outcomes included postoperative pain scores and adverse events. Both groups had comparable baseline and surgical characteristics. On POD 1, the QoR-40 score was higher in the OFA group than in the OSA group (164.3 ± 10.8 vs. 158.7 ± 10.6; mean difference: 5.6, 95% CI: 1.1, 10.0; p = 0.015), though this did not meet the pre-specified minimal clinically important difference of 6.3. The visual analog scale score was lower in the OFA group as compared to the OSA group at 0–1 h (4.2 ± 2.3 vs. 6.2 ± 2.1; p < 0.001) and 1–4 h after surgery (3.4 ± 1.8 vs. 4.6 ± 1.9; p = 0.003). The OFA group had a lower incidence of PONV (2 [4.4%] vs. 9 [19.6%]; p = 0.049) and postoperative shivering (4 [8.9%] vs. 13 [28.3%]; p = 0.030) than the OSA group at 0–1 h after surgery. Using OFA with ketamine proved feasible, as indicated by the stable intraoperative hemodynamics and absence of intraoperative awareness. Patients undergoing VATS with OFA using ketamine showed a statistically significant, but clinically insignificant, QoR improvement compared to those receiving OSA with remifentanil.
Outcomes of I-125 Low-Dose-Rate Brachytherapy in Patients with Localized Prostate Cancer: A Comprehensive Analysis from a Specialized Tertiary Referral Center
Authors: Schubert Philipp , Strnad Vratislav , Höfler Daniel , Schweizer Claudia , Putz Florian , Lotter Michael , Kreppner Stephan , Karius Andre , Fietkau Rainer , Merten Ricarda
Published: August 2024

Low-dose-rate (LDR) brachytherapy with I-125 seeds is one of the most common primary tumor treatments for low-risk and low-intermediate-risk prostate cancer. This report aimed to present an analysis of single-institution long-term results. We analyzed the treatment outcomes of 119 patients with low- and intermediate-risk prostate cancer treated with LDR brachytherapy at our institution between 2014 and 2020. The analysis focused on biochemical recurrence rates (BRFS), overall survival (OS), cumulative local recurrence rate (CLRR), and the incidence of acute and late toxicities. Patient-reported quality of life measures were also evaluated to provide a holistic view on the treatment’s impact. The median follow-up period was 46 months. CLRR was 3.3% (4/119), five-year BRFS was 87%, and the five-year OS rate was 95%. Dysuria was the most common acute urinary toxicity, reported in 26.0% of patients as grade 1 and 13.4% as grade 2. As a late side effect, 12.6% of patients experienced mild dysuria. Sexual dysfunction persisted in 6.7% of patients as grade 1, 7.5% as grade 2, and 10.0% as grade 3. LDR brachytherapy in patients with prostate cancer is an effective treatment, with favorable clinical outcomes and manageable toxicity. The low CLRR and high OS rates, as well as low incidence of severe side effects, support the continued use of LDR brachytherapy as a primary treatment modality for localized prostate cancer.
Outcomes of Active Middle Ear Implants: Speech Perception and Quality of Life
Authors: Salamah Marzouqi , Alradhi Athair , Alzhrani Farid , Yousef Medhat
Published: August 2024

Objective: To evaluate audiological outcomes, quality of life, and complications in patients implanted with Active middle ear implants (AMEI). The secondary objective is to investigate the required duration after implantation to reach satisfactory outcomes. Methods: This retrospective study included 31 patients implanted with Active middle ear implants (AMEI) with different methods of floating mass transducer attachment. Patients with incomplete medical records and those who did not respond to postoperative follow-up were excluded. Patients were assessed preoperatively, and at one, three, and six months postoperatively. The assessment included Pure Tone Average (PTA4), speech reception threshold (SRT), and speech discrimination score (SDS). The Speech Spatial and Qualities of Hearing scale (SSQ12) was also used to evaluate levels of satisfaction. Result: There are no significant differences found in PTA and SRT between the 3-, 6-, and 12-month visits. The speech reception threshold (SRT) showed a statistically significant improvement at 3, 6, and 12 months post-operative measures compared to pre-operative. Additionally, the SDS exhibited a significant increase only after 12 months, compared to the 3-month time point. However, satisfaction levels did not significantly differ between the 6-month and 12-month measurements following surgery. Conclusion: The Vibrant Soundbridge improves subjective satisfaction scores and audiological test scores in patients with different types of hearing loss. AMEI has a low risk of medical or surgical complications, the ease of using a hearing implant, and the social benefits of good hearing and communication.
Assessing the Impact of IL-6 and Serotonin on Pain and Symptomatology in Fibromyalgia: An Exploratory Clinical Study
Authors: Loçasso Felipe , Filho Hélcio , Alvarenga Regina , Schimidt Sérgio , Fiorelli Filipe , Ramos Plínio , Leidersnaider Sônia , Blum Kenneth , Lewandrowski Kai-Uwe , Cunha-Junior Edezio , Fiorelli Rossano
Published: August 2024

Background and Objectives: Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome characterized by widespread pain and a variety of other symptoms, including fatigue, cognitive dysfunction, and sleep disturbances. Recent research has highlighted the potential role of pro-inflammatory cytokines and neurotransmitters in the pathophysiology of FM. This study aimed to investigate the relationship between serum levels of interleukin-6 (IL-6) and serotonin with the clinical parameters observed in patients with fibromyalgia. Additionally, it sought to analyze the similarities and differences among the different groups classified by symptom severity. Materials and Methods: This cross-sectional study included 26 female patients aged 20–70 diagnosed with FM according to the American College of Rheumatology (ACR) 2016 criteria and 14 healthy controls (HCs). Serum levels of IL-6 and serotonin were measured using electrochemiluminescence and high-performance liquid chromatography (HPLC), respectively. Results: FM patients exhibited significantly higher pain scores (VAS), anxiety, and depression levels compared to HCs. FIQ-R scores were significantly elevated in FM patients, with stratification showing 3.8% mild, 65.4% moderate, 23.1% severe, and 7.7% very severe cases. While no significant difference in IL-6 levels was observed between the FM patients and HCs, a trend towards increased IL-6 levels in patients with higher FIQ-R scores was noted. Serum serotonin levels were significantly lower in the FM patients than in the HCs, with moderate patients having lower levels than those classified as severe and very severe. Conclusions: The study underscores the potential role of IL-6 and serotonin in the pathophysiology of FM, suggesting that these biomarkers could be relevant in assessing the severity and impact of FM. Further research is needed to elucidate these relationships and their implications for developing personalized treatment strategies.
Socioeconomic Gender Variables Impact the Association between Hypertension and Chronic Health Issues: Cross-Sectional Study
Authors: Lindner Simon David , Gisinger Teresa , Klimek Peter , Kautzky-Willer Alexandra
Published: August 2024

Our aim is to investigate if sex and gender influence the association of hypertension and their comorbidities. We investigated how gender differences in five socioeconomic factors impact the relation between hypertension and ten comorbidities including diabetes mellitus, renal disease, and chronic pulmonary disease in European countries grouped by their gender inequality index using representative survey data from the European Health Interview Survey. Using logistic regressions, we compute the ratio of odds ratios in females versus males. Therefore, an ORR > 1 is associated with a higher odds ratio for females than for males while an ORR < 1 means the opposite. To account for multiple hypothesis testing, we applied the Bonferroni correction. Hypertension in both sexes was associated with lower educational level, being unemployed, and lower income. In males, being divorced/widowed (OR1.12, p < 0.001) had an association to hypertension, whereas in females, being common-law/married (OR1.30, p < 0.001) and being divorced/widowed (OR1.17, p < 0.001) was associated with a higher risk for hypertension. Moreover, in hypertension, females who worked had an association with myocardial infarction (OR1.39, p < 0.001) and having post-secondary education had an association with arthrosis (OR 1.35, p < 0.001) compared to males. Our findings show that gender variables influence the association of hypertension and comorbidities, especially in females. These results can be used to inform targeted prevention measures taking gender-specific contextual factors into account.
Foundations for a Personalized Psycho-Oncology: The State of the Art
Authors: Perna Giampaolo , Pinto Eleonora , Spiti Alessandro , Torti Tatiana , Cucchi Michele , Caldirola Daniela
Published: August 2024

Personalized psycho-oncology represents a major challenge for the holistic care of cancer patients. It focuses on individualized psychotherapeutic and psychiatric interventions to address specific psychological needs. This narrative review summarizes the current literature on personalized psycho-oncology and highlights the prevalence and impact of psychiatric/psychological disorders in cancer patients. Personalized approaches, including tailored interventions and interdisciplinary collaboration, have been shown to be effective in improving mental health and overall quality of life. The integration of inflammatory biomarkers into treatment plans is a promising but challenging way to alleviate mental health problems. In addition, there is a need for specific diagnostic tools and treatment guidelines that take into account the specific psychological impact of different types of cancer. Future research should aim to refine these personalized strategies, improve diagnostic accuracy, and evaluate the cost-effectiveness of these interventions to improve both the psychological well-being and treatment outcomes of cancer patients.
Evaluation of CNPase and TGFβ1/Smad Signalling Pathway Molecule Expression in Sinus Epithelial Tissues of Patients with Chronic Rhinosinusitis with (CRSwNP) and without Nasal Polyps (CRSsNP)
Authors: Piszczatowska Katarzyna , Czerwaty Katarzyna , Dżaman Karolina , Jermakow Natalia , Brzost Jacek , Kantor Ireneusz , Ludwig Nils , Szczepański Mirosław J.
Published: August 2024

Chronic rhinosinusitis with and without nasal polyps (CRSwNP and CRSsNP, respectively) is a chronic inflammatory disease affecting almost 5 to 12% of the population and exhibiting high recurrence rates after functional endoscopic sinus surgery (FESS). TGFβ1-related pathways contribute to tissue remodelling, which is one of the key aspects of CRS pathogenesis. Additionally, adenosine signalling participates in inflammatory processes, and CNPase was shown to elevate adenosine levels by metabolizing cyclic monophosphates. Thus, the aim of this study was to assess the expression levels of Smad2, pSmad3, TGFβ1, and CNPase protein via immunohistochemistry in sinus epithelial tissues from patients with CRSwNP (n = 20), CRSsNP (n = 23), and non-CRS patients (n = 8). The expression of Smad2, pSmad3, TGFβ1, and CNPase was observed in the sinus epithelium and subepithelial area of all three groups of patients, and their expression correlated with several clinical symptoms of CRS. Smad2 expression was increased in CRSsNP patients compared to CRSwNP patients and controls (p = 0.001 and p < 0.001, respectively), pSmad3 expression was elevated in CRSwNP patients compared to controls (p = 0.007), TGFβ1 expression was elevated in CRSwNP patients compared to controls (p = 0.009), and CNPase was decreased in CRSsNP patients compared to controls (p = 0.03). To the best of our knowledge, we are the first to demonstrate CNPase expression in the upper airway epithelium of CRSwNP, CRSsNP, and non-CRS patients and point out a putative synergy between CNPase and TGFβ1/Smad signalling in CRS pathogenesis that emerges as a novel still undiscovered aspect of CRS pathogenesis; further studies are needed to explore its function in the course of the chronic inflammation of the upper airways.
IgE-Mediated Legume Allergy: A Pediatric Perspective
Authors: Mastrorilli Carla , Chiera Fernanda , Arasi Stefania , Giannetti Arianna , Caimmi Davide , Dinardo Giulio , Gracci Serena , Pecoraro Luca , Miraglia Del Giudice Michele , Bernardini Roberto
Published: August 2024

Legumes are an inexpensive and essential protein source worldwide. The most consumed legumes include peanuts, soybeans, lentils, lupines, peas, common bean and chickpeas. In addition, the food industry is growing interested in expanding the use of legumes to partially replace or substitute cereals. Legumes were described to cause IgE-mediated allergies, and their growing use may also increase the incidence of allergy. The epidemiology of legume allergy varies by region; peanuts and soybeans are the legumes most involved in food allergies in Western countries, whereas lentils, peas, and chickpeas are reported as culprit allergens mainly in the Mediterranean area and India. This review, edited by the Italian Society of Pediatric Allergology and Immunology, summarizes the scientific literature on legume allergy in children and proposes a diagnostic workup and therapeutic approach.
Novel RAI1:c.2736delC Variant in Smith–Magenis Syndrome: Identification by Whole Genome Sequencing and Joint Analysis
Authors: Cuk Mario , Unal Busra , Jandric Nives , Hayes Connor P. , Walker McKenzie , Abraamyan Feruza , Gornik Kristina Crkvenac , Ghazani Arezou A.
Published: August 2024

Smith–Magenis syndrome is a complex neurobehavioral genetic disorder with a broad phenotypic spectrum. While the etiology of SMS is commonly attributed to one-copy interstitial deletion in the 17p11.2 region (90–95% of cases), variants identified by sequence analysis in RAI1 have also been reported in 5–10% of cases. In this study, we report a 9-year-old male with global cognitive and psychomotor developmental delay, musculoskeletal and cardiovascular abnormalities, and dysmorphic craniofacial features. Joint analysis was performed on the whole-genome sequencing data obtained from the proband, unaffected parents, and unaffected brother. This quad analysis identified the novel de novo RAI1:c.2736delC variant. This is the first report of this variant in the literature. This report highlights the details of genome analysis and the patient’s phenotypic spectrum.
Classifying the Cognitive Performance of Drivers While Talking on Hands-Free Mobile Phone Based on Innovative Sensors and Intelligent Approach
Authors: Ossai Boniface Ndubuisi , Sharif Mhd Saeed , Fu Cynthia , Moncy Jijomon Chettuthara , Murali Arya , Alblehai Fahad
Published: August 2024

The use of mobile phones while driving is restricted to hands-free mode. But even in the hands-free mode, the use of mobile phones while driving causes cognitive distraction due to the diverted attention of the driver. By employing innovative machine-learning approaches to drivers’ physiological signals, namely electroencephalogram (EEG), heart rate (HR), and blood pressure (BP), the impact of talking on hands-free mobile phones in real time has been investigated in this study. The cognitive impact was measured using EEG, HR, and BP data. The authors developed an intelligent model that classified the cognitive performance of drivers using physiological signals that were measured while drivers were driving and reverse bay parking in real time and talking on hands-free mobile phones, considering all driver ages as a complete cohort. Participants completed two numerical tasks varying in difficulty while driving and reverse bay parking. The results show that when participants did the hard tasks, their theta and lower alpha EEG frequency bands increased and exceeded those when they did the easy tasks. The results also show that the BP and HR under phone condition were higher than the BP and HR under no-phone condition. Participants’ cognitive performance was classified using a feedforward neural network, and 97% accuracy was achieved. According to qualitative results, participants experienced significant cognitive impacts during the task completion.
Assessing the Effects of Climate Variability on Maize Yield in the Municipality of Dschang—Cameroon
Authors: Tchouandem Nzali Coretta , Abdelbaki Cherifa , Kumar Navneet
Published: August 2024

Evidence-based research on the effects of rainfall, temperature, and relative humidity variability on maize yield is essential for understanding the climate dynamics of, and paving the way for informed adaptive solutions to future potential negative impacts in, Dschang-Cameroon. This study employed the non-parametric Mann–Kendall and Sen’s slope method to detect trends in climate variables and maize yield in the period between 1990 to 2018. Pearson correlation and multilinear regression (MLR) analyses were also used to establish the linear relationship between climate variables and maize yield, and to explore the behavior of the response variable (maize yield) with the predictor variables (climatic variables), respectively. In addition, perceptions of climate variability and its impact on maize yield from a hundred farmers were collected through a questionnaire and analyzed in SPSS. Twenty key informants’ interviews (KII) were conducted using a semi-structured interview and analyzed by thematic analysis. The results showed that the minimum temperature exhibited a decreasing trend at a rate of 0.039 °C per annum, whereas relative humidity had an increasing trend of 0.25% per annum with statistical significance at p = 0.001. In addition, a decreasing trend of rainfall, at a rate of 4.94 mm per annum, was observed; however, this had no statistical significance. Furthermore, the MLR analysis showed that mean temperature and relative humidity have an inversely proportional but statistically significant relationship with maize yield (p = 0.046 and p = 0.001, respectively). The analysis of farmers’ perceptions confirmed the results of trend analyses of decreasing rainfall and increasing maximum temperatures. Moreover, the farmers asserted that the vulnerability of farmers to climate variability is also linked to gender and locality, where women’s outputs are more assailable and farms in low-lying areas are more prone to floods. The high price of farm inputs was also reported as a key factor, other than climate variability, hindering the flourishing of the maize sector in Dschang. Finally, an analysis of the KII indicated the inadequate implementation of flagship agricultural programs in the locality.
Quality of Life and Attachments to Rural Settlements: The Basis for Regeneration and Socio-Economic Sustainability
Authors: Tešin Aleksandra , Dragin Aleksandra S. , Mijatov Ladičorbić Maja , Jovanović Tamara , Zadel Zrinka , Surla Tamara , Košić Kristina , Amezcua-Ogáyar Juan Manuel , Calahorro-López Alberto , Kuzman Boris , Stojanović Vladimir
Published: August 2024

Balanced territorial development and improving living conditions have become the focus of rural development policies. As the number of young people moving to cities or other countries is increasing, rural settlements face serious demographic disbalances and aging societies. Quality of life and place attachment are both key variables in enhancing the social and economic capacities of rural and undeveloped communities and reducing youth out-migration. However, this topic remains underexplored, especially among younger generations, who are critical for further socio-economic sustainability. Thus, the main goal of this study was to explore young residents’ perceptions about quality of life, level of attachment to their rural homes, and their interrelationship. This study was conducted among 299 participants in rural areas of Serbia and Croatia. The results identified two quality of life factors: (1) satisfaction with the quality of infrastructure and (2) satisfaction with culture and education. Three attachment factors were extracted, among which place identity was the strongest. Additionally, the influence of quality of life and socio-demographic characteristics on place attachment was confirmed. These results provide new insights that could be very useful in creating strategies and initiatives for rural planning and strengthening rural areas’ social, economic, and environmental sustainability.
Introduction to the Special Issue: Investigating Language Variation and Change in Portuguese
Authors: Amaral Patrícia
Published: August 2024

This Issue focuses on morphosyntactic variation and change in Portuguese [...]
Perspectives of Decision Support System TeleRehab in the Management of Post-Stroke Telerehabilitation
Authors: Nikolaev Vitaly A. , Nikolaev Alexander A.
Published: August 2024

Stroke is the main cause of disability among adults. Decision-making in stroke rehabilitation is increasingly complex; therefore, the use of decision support systems by healthcare providers is becoming a necessity. However, there is a significant lack of software for the management of post-stroke telerehabilitation (TR). This paper presents the results of the developed software “TeleRehab” to support the decision-making of clinicians and healthcare providers in post-stroke TR. We designed a Python-based software with a graphical user interface to manage post-stroke TR. We searched Scopus, ScienceDirect, and PubMed databases to obtain research papers with results of clinical trials for post-stroke TR and to form the knowledge base of the software. The findings show that TeleRehab suggests recommendations for TR to provide practitioners with optimal and real-time support. We observed feasible outcomes of the software based on synthetic data of patients with balance problems, spatial neglect, and upper and lower extremities dysfunctions. Also, the software demonstrated excellent usability and acceptability scores among healthcare professionals.
Evolutionary Game-Theoretic Approach to the Population Dynamics of Early Replicators
Authors: Mariano Matheus , Fontanari José
Published: August 2024

The population dynamics of early replicators has revealed numerous puzzles, highlighting the difficulty of transitioning from simple template-directed replicating molecules to complex biological systems. The resolution of these puzzles has set the research agenda on prebiotic evolution since the seminal works of Manfred Eigen in the 1970s. Here, we study the effects of demographic noise on the population dynamics of template-directed (non-enzymatic) and protein-mediated (enzymatic) replicators. We borrow stochastic algorithms from evolutionary game theory to simulate finite populations of two types of replicators. These algorithms recover the replicator equation framework in the infinite population limit. For large but finite populations, we use finite-size scaling to determine the probability of fixation and the mean time to fixation near a threshold that delimits the regions of dominance of each replicator type. Since enzyme-producing replicators cannot evolve in a well-mixed population containing replicators that benefit from the enzyme but do not encode it, we study the evolution of enzyme-producing replicators in a finite population structured in temporarily formed random groups of fixed size n. We argue that this problem is identical to the weak-altruism version of the n-player prisoner’s dilemma, and show that the threshold is given by the condition that the reward for altruistic behavior is equal to its cost.
To Be, or Not to Be … Pectoral Angina? The Pain Is the Same, but the Etiology Is Different—A Case Report
Authors: Rosca Ciprian Ilie , Lighezan Daniel Florin , Cozma Gabriel Veniamin , Branea Horia Silviu , Nisulescu Daniel Dumitru , Zus Adrian Sebastian , Morariu Stelian I. , Kundnani Nilima Rajpal
Published: August 2024

Background: Chest pain is one of the most common causes of emergency room visits and also accounts for numerous visits to the family physician’s office or Outpatient Clinics of cardiology or internal medicine. Case Report: Here we present a case of a 48-year-old female patient who presented to our hospital emergency unit but refused hospital admission. She presented in our Outpatient Clinic with a complaint of typical chest pain indicating it to be of coronary origin. A computed tomography (CT) coronary angiography for the evaluation of this chest pain was indicated. While ruling out the coronary origin of this chest pain, we were surprised to have incidentally identified the presence of an esophageal tumor mass that had intimate contact with carina of the trachea. After the diagnosis of esophageal leiomyoma was made and its surgical treatment was performed, the patient was asymptomatic. Approximately one year after the surgical intervention was performed, following the cessation of antiplatelet therapy and statin, the patient returned to our Outpatient Clinic complaining of chest pain again with the same characteristics as previously presented, being terrified by the possibility of the recurrence of the esophageal leiomyoma. Upon resuming investigations, it was proven through coronary angio-CT evaluation that the etiology of the chest pain was indeed coronary this time. However, the patient still refused hospital admission and the performance of percutaneous coronary angiography with the potential implantation of a coronary stent. Conclusions: Chest pain can be due to various underlying pathologies and should not be neglected. A thorough investigation and timely management are key to treating this possible fatal symptom. In our case, the patient presented twice with the complaint of typical chest pain indicating a possible coronary event, but at the first presentation, it was due to esophageal leiomyoma, while a year later, the patient had similar pain, which was indeed this time due to coronary blockage. Hence, it is of utmost importance to think of all possible scenarios and to investigate accordingly, leaving no stone unturned.
Co-Occurrence of Cyanotoxins and Phycotoxins in One of the Largest Southeast Asian Brackish Waterbodies: A Preliminary Study at the Tam Giang—Cau Hai Lagoon (Vietnam)
Authors: Sahoo Devleena , Tran Ngoc Khanh Ni , Nguyen Thi Gia-Hang , Ho Thi Thu Hoai , Phan Thi Thuy Hang , Hoang Duong Thu Huong , Binh Ngo Huu , Nguyen Thi Thu Lien , Doc Luong Quang , Bouaïcha Noureddine , Nguyen-Quang Tri
Published: August 2024

The Tam Giang-Cau Hai lagoon (TGCH) in Thua Thien Hue province (Vietnam) is a marsh/lagoon system and ranks among the largest waterbodies in Southeast Asia. It plays a significant role in terms of both socio-economic and environmental resources. However, anthropogenic stress, as well as the discharge of untreated domestic and industrial sewage with agricultural runoff from its three major tributaries, dramatically damages the water quality of the lagoon. Especially after heavy rain and flash floods, the continuous degradation of its water quality, followed by harmful algal and cyanobacterial bloom patterns (HABs), is more perceptible. In this study, several physicochemical factors, cyanotoxins (anatoxins (ATXs), saxitoxins (STXs), microcystins (MCs)), phycotoxins (STXs, okadaic acid (OA), and dinophysistoxins (DTXs)) were analyzed in water and shellfish samples from 13 stations in June 2023 from 13 stations, using enzyme-linked immunosorbent assay (ELISA) kits for the ATXs and STXs, and the serine/threonine phosphatase type 2A (PP2A) inhibition assay kit for the MCs, OA, and DTXs. The results showed for the first time the co-occurrence of freshwater cyanotoxins and marine phycotoxins in water and shellfish samples in this lagoon. Traces of ATXs and STXs were detected in the shellfish and the orders of magnitude were below the seafood safety action levels. However, toxins inhibiting the PP2A enzyme, such as MCs and nodularin (NODs), as well as OA and DTXs, were detected at higher concentrations (maximum: 130.4 μg equiv. MC-LR/kg shellfish meat wet weight), approaching the actionable level proposed for this class of toxin in shellfish (160 μg of OA equivalent per kg of edible bivalve mollusk meat). It is very important to note that due to the possible false positives produced by the ELISA test in complex matrices such as a crude shellfish extract, this preliminary and pilot research will be repeated with a more sophisticated method, such as liquid chromatography coupled with mass spectroscopy (LC-MS), in the upcoming research plan.
Electrochemical Behavior of Plasma-Nitrided Austenitic Stainless Steel in Chloride Solutions
Authors: Zatkalíková Viera , Drímalová Petra , Balin Katarzyna , Slezák Martin , Markovičová Lenka
Published: August 2024

The application possibilities of austenitic stainless steels in high friction, abrasion, and sliding wear conditions are limited by their inadequate hardness and tribological characteristics. In order to improve these properties, the thermochemical treatment of their surface by plasma nitriding is suitable. This article is focused on the corrosion resistance of conventionally plasma-nitrided AISI 304 stainless steel (530 °C, 24 h) in 0.05 M and 0.5 M sodium chloride solutions at room temperature (20 ± 3 °C), tested by potentiodynamic polarization and electrochemical impedance spectroscopy. Optical microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy are used for nitrided layer characterization. The experiment results confirmed the plasma-nitrided layer formation of increased micro-hardness related to the presence of Cr2N chromium nitrides and higher surface roughness compared to the as-received state. Both of the performed independent electrochemical corrosion tests point to a significant reduction in corrosion resistance after the performed plasma nitriding, even in a solution with a very low chloride concentration (0.05 mol/L).
Microstructure and Properties of Mg-Gd-Y-Zn-Mn High-Strength Alloy Welded by Friction Stir Welding
Authors: Wang Jinxing , Wan Zhicheng , Wang Xiyu , Wang Jiaxu , Zou Yi , Wang Jingfeng , Pan Fusheng
Published: August 2024

Mg-Gd-Y-Zn-Mn (MVWZ842) is a kind of high rare earth magnesium alloy with high strength, high toughness and multi-scale strengthening mechanisms. After heat treatment, the maximum tensile strength of MVWZ842 alloy is more than 550 MPa, and the elongation is more than 5%. Because of its great mechanical properties, MVWZ842 has broad application potential in aerospace and rail transit. However, the addition of high rare earth elements makes the deformation resistance of MVWZ842 alloy increase to some extent. This leads to the difficulty of direct plastic processing forming and large structural part shaping. Friction stir welding (FSW) is a convenient fast solid-state joining technology. When FSW is used to weld MVWZ842 alloy, small workpieces can be joined into a large one to avoid the problem that large workpieces are difficult to form. In this work, a high-quality joint of MVWZ842 alloy was achieved by FSW. The microstructure and properties of this high-strength magnesium alloy after friction stir welding were studied. There was a prominent onion ring characteristic in the nugget zone. After the base was welded, the stacking fault structure precipitated in the grain. There were a lot of broken long period stacking order (LPSO) phases on the retreating side of the nugget zone, which brought the effect of precipitation strengthening. Nano-α-Mn and the broken second phase dispersed in the matrix in the nugget zone, which made the grains refine. A relatively complete dynamic recrystallization occurred in the nugget zone, and the grains were refined. The welding coefficient of the welded joint exceeded 95%, and the hardness of the weld nugget zone was higher than that of the base. There were a series of strengthening mechanisms in the joint, mainly fine grain strengthening, second phase strengthening and solid solution strengthening.
Property Enhancement of Recycled Coarse Aggregate and Its Concrete under CO2-Accelerated Curing Treatment
Authors: Li Yingying , Long Jia , Chen Xiang
Published: August 2024

The poor properties of recycled coarse aggregate (RCA) and recycled coarse aggregate concrete (RCAC) are considered key constraints hindering the reuse of this waste resource in marine engineering. The CO2-based accelerated carbonation method, which utilizes the alkali aggregate properties of RCA to achieve CO2 uptake and sequestration while significantly enhancing its properties, has attracted widespread attention. However, the degree of improvement in the properties of RCA under different initial moisture conditions (IMCs) and aggregate particle sizes (APSs) after CO2-accelerated carbonation remains unclear. Moreover, the quantitative effect of carbonated recycled coarse aggregate (CRCA), which is obtained from RCA samples with the optimal initial moisture conditions, on the improvement of RCAC under optimal accelerated carbonation modification conditions still needs to be studied in depth. For this investigation, a CO2-accelerated carbonation experiment was carried out on RCA samples with different IMCs and APSs, and the variations in the properties of RCA with respect to its IMC and APS were assessed. The degree of accelerated carbonation modification of RCA under different IMCs and APSs was quantified, and the optimal initial moisture conditions for enhancing the properties of the RCA were confirmed. By preparing concrete specimens based on the natural coarse aggregate, RCA, and CRCA with the best initial moisture conditions (considering the same concrete–water proportion), the effect of CRCA on the workability, mechanical properties, and durability of the corresponding concrete specimen was determined. The findings of this study can be used to effectively promote the sustainable development of marine science and engineering in the future and contribute to global dual-carbon goals, which are of great practical significance and scientific value.
Effect of Coherent Nanoprecipitate on Strain Hardening of Al Alloys: Breaking through the Strength-Ductility Trade-Off
Authors: Wu Pan , Song Kexing , Liu Feng
Published: August 2024

So-called strength-ductility trade-off is usually an inevitable scenario in precipitation-strengthened alloys. To address this challenge, high-density coherent nanoprecipitates (CNPs) as a microstructure effectively promote ductility though multiple interactions between CNPs and dislocations (i.e., coherency, order, or Orowan mechanism). Although some strain hardening theories have been reported for individual strengthening, how to increase, artificially and quantitatively, the ductility arising from cooperative strengthening due to the multiple interactions has not been realized. Accordingly, a dislocation-based theoretical framework for strain hardening is constructed in terms of irreversible thermodynamics, where nucleation, gliding, and annihilation arising from dislocations have been integrated, so that the cooperative strengthening can be treated through thermodynamic driving force ∆G and the kinetic energy barrier. Further combined with synchrotron high-energy X-ray diffraction, the current model is verified. Following the modeling, the yield stress σy is proved to be correlated with the modified strengthening mechanism, whereas the necking strain εn is shown to depend on the evolving dislocation density and, essentially, the enhanced activation volume. A criterion of high ∆G-high generalized stability is proposed to guarantee the volume fraction of CNPs improving σy and the radius of CNPs accelerating εn. This strategy of breaking the strength-ductility trade-off phenomena by controlling the cooperative strengthening can be generalized to designing metallic structured materials.
Microstructure-Based Flow Stress Model to Predict Machinability of Inconel 718
Authors: Yin Qingan , Chen Hui , Chen Jianxiong , Xie Yu , Shen Ming , Huang Yuhua
Published: August 2024

Due to its exceptional mechanical and chemical properties at high temperatures, Inconel 718 is extensively utilized in industries such as aerospace, aviation, and marine. Investigating the flow behavior of Inconel 718 under high strain rates and high temperatures is vital for comprehending the dynamic characteristics of the material in manufacturing processes. This paper introduces a physics-based constitutive model that accounts for dislocation motion and its density evolution, capable of simulating the plastic behavior of Inconel 718 during large strain deformations caused by machining processes. Utilizing a microstructure-based flow stress model, the machinability of Inconel 718 in terms of cutting forces and temperatures is quantitatively predicted and compared with results from orthogonal cutting experiments. The model’s predictive precision, with a margin of error between 5 and 8%, ensures reliable consistency and enhances our comprehension of the high-speed machining dynamics of Inconel 718 components.
Analysis of the Suitability of Ultrasonic Testing for Verification of Nonuniform Welded Joints of Austenitic–Ferritic Sheets
Authors: Rawicki Łukasz , Krawczyk Ryszard , Słania Jacek , Peruń Grzegorz , Golański Grzegorz , Łuczak Katarzyna
Published: August 2024

The purpose of the presented research was to determine the suitability of using ultrasonic testing (UT) to inspect heterogeneous, from a material point of view, welded joints on the example of the joints of a ferritic steel element with elements made of an austenitic steel. The echo technique with transverse (SEK) and longitudinal wave heads (SEL) addressed this issue. Due to the widespread use of 13CrMo4-5 and X2CrNiMo17-12-2 steel grades in the energy industry, they were selected as the test materials for the study. The objects of the presented research were welded joint specimens with thicknesses of 8, 12, and 16 mm and dimensions of 300 × 300 mm, made using the 135 metal active gas (MAG) process with the use of the Lincoln 309LSi wire—a ferritic–austenitic filler material. The stages of the research task were (1) making distance–amplitude curve (DAC) patterns from the test materials; (2) preparation of specimens of welded joints with artificial discontinuities in the form of through-holes; (3) performing UT tests on welded joints with artificial discontinuities using heads with 60° and 70° angles for the transverse wave and angle heads for longitudinal waves with similar beam insertion angles; (4) selection, by radiographic testing (RT), of welded joint specimens with natural discontinuities in the form of a lack of sidewall fusion; (5) performing UT tests on welded joints with natural discontinuities, using heads as welded joints with artificial discontinuities. It was found that (1) the highest sensitivity of discontinuity detection was obtained by performing tests on the ferritic steel side, which is due to the lower attenuation of the ultrasonic wave propagating in ferritic steel compared to austenitic steel; (2) the best detection of discontinuities could be obtained using a longitudinal ultrasonic wave; (3) there is a relationship between the thickness of the welded elements, the angle of the ultrasonic beam introduction, and the effectiveness of discontinuity detection.
A Non-Relativistic 2D Quantum System and Its Thermo-Magnetic Properties with a Generalized Pseudo-Harmonic Oscillator
Authors: Alrebdi Haifa I. , Ikot Akpan N. , Horchani Ridha , Okorie Uduakobong S.
Published: August 2024

In this work, we examine the thermo-magnetic characteristics and energy spectra of a system exposed to both magnetic and Aharonov–Bohm (AB) fields with the existence of an interaction potential that is pseudo-harmonic. Explicit calculations of the eigen-solutions are performed with the expanded Nikiforov–Uvarov formalism. The confluent Heun function is used to represent the equivalent wave functions. If the AB and magnetic fields are gone, quasi-degeneracy in the system’s energy levels is shown by a numerical analysis of the energy spectrum. Additionally, we provided a visual representation of how the AB and magnetic fields affected the system’s thermo-magnetic characteristics. Our results show a strong dependence of thermo-magnetic properties on temperature, screening parameters, external magnetic fields, and AB fields.
On the Equivalence between Differential and Integral Forms of Caputo-Type Fractional Problems on Hölder Spaces
Authors: Cichoń Mieczysław , Salem Hussein A. H. , Shammakh Wafa
Published: August 2024

As claimed in many papers, the equivalence between the Caputo-type fractional differential problem and the corresponding integral forms may fail outside the spaces of absolutely continuous functions, even in Hölder spaces. To avoid such an equivalence problem, we define a “new” appropriate fractional integral operator, which is the right inverse of the Caputo derivative on some Hölder spaces of critical orders less than 1. A series of illustrative examples and counter-examples substantiate the necessity of our research. As an application, we use our method to discuss the BVP for the Langevin fractional differential equation dψβ,μdtβdψα,μdtα+λx(t)=f(t,x(t)),t∈[a,b],λ∈R, for f∈C[a,b]×R and some critical orders β,α∈(0,1), combined with appropriate initial or boundary conditions, and with general classes of ψ-tempered Hilfer problems with ψ-tempered fractional derivatives. The BVP for fractional differential problems of the Bagley–Torvik type was also studied.
Bounds of Eigenvalues for Complex q-Sturm–Liouville Problem
Authors: Han Xiaoxue
Published: August 2024

The eigenvalues of complex q-Sturm–Liouville boundary value problems are the focus of this paper. The coefficients of the corresponding q-Sturm–Liouville equation provide the lower bounds on the real parts of all eigenvalues, and the real part of the eigenvalue and the coefficients of this q-Sturm–Liouville equation provide the bounds on the imaginary part of each eigenvalue.
MXene/Carbon Nanocomposites for Water Treatment
Authors: Keneshbekova Aruzhan , Smagulova Gaukhar , Kaidar Bayan , Imash Aigerim , Ilyanov Akram , Kazhdanbekov Ramazan , Yensep Eleonora , Lesbayev Aidos
Published: August 2024

One of the most critical problems faced by modern civilization is the depletion of freshwater resources due to their continuous consumption and contamination with different organic and inorganic pollutants. This paper considers the potential of already discovered MXenes in combination with carbon nanomaterials to address this problem. MXene appears to be a highly promising candidate for water purification due to its large surface area and electrochemical activity. However, the problems of swelling, stability, high cost, and scalability need to be overcome. The synthesis methods for MXene and its composites with graphene oxide, carbon nanotubes, carbon nanofibers, and cellulose nanofibers, along with their structure, properties, and mechanisms for removing various pollutants from water, are described. This review discusses the synthesis methods, properties, and mechanisms of water purification using MXene and its composites. It also explores the fundamental aspects of MXene/carbon nanocomposites in various forms, such as membranes, aerogels, and textiles. A comparative analysis of the latest research on this topic shows the progress in this field and the limitations for the practical application of MXene/carbon nanocomposites to solve the problem of drinking water scarcity. Consequently, this review demonstrates the relevance and promise of the material and underscores the importance of further research and development of MXene/carbon nanocomposites to provide effective water treatment solutions.
The Effect of Interpass Temperature on the Mechanical Properties and Microstructure of Components Made by the WAAM Method from Inconel 718 Alloy
Authors: Maronek Milan , Sugra Filip , Bartova Katarina , Barta Jozef , Dománková Mária , Urminsky Jan , Pasak Matej
Published: August 2024

The following study examines the impact of temperature on the deposition of components using Cold Metal Transfer–Wire Arc Additive Manufacturing technology. In the experiment, two overlay weld wall structures were created by applying an interpass temperature of 100 °C and without additional cooling. Subsequently, the microstructural and mechanical properties were observed. No changes in the microstructure due to the application of the interpass temperature were confirmed, and the microstructure of the manufactured components, in both cases, consisted of columnar dendrites. It was found that applying an interpass temperature reduced the average ultimate tensile strength by nearly 65 MPa and the average offset yield strength by 82 MPa. The influence of the cooling strategy on the resulting microstructure was not confirmed. Transmission electron microscopy analysis confirmed the presence of strengthening phases γ′/γ″ in both components; however, a larger amount of the strengthening phase γ″ was found in the component manufactured without the application of an interpass temperature.
Recovery of Silver and Lead from Jarosite Residues by Roasting and Reducing Pyrometallurgical Processes
Authors: Jiménez-Lugos Cancio , Flores-Favela Manuel , Romero-Serrano Antonio , Hernández-Ramírez Aurelio , López-Rodríguez Josué , Cuéllar-Herrera Lorena , Colin-García Eduardo
Published: August 2024

This work focuses on the recovery of lead and silver from jarosite waste by a three-stage process: drying, roasting and reduction at 100 °C, 700 °C and 1400 °C, respectively. A flux mixture with 48 mass% CaO and 52% SiO2 was used for the reduction stage. A gas consisting of 70 vol% CO and 30 vol% CO2 was used as a reducing agent. To select the temperatures and the amount of flux and reducing agent, a characterization of the jarosite waste was carried out using thermogravimetry and high-temperature X-ray diffraction, as well as a thermodynamic study of the effects of the process parameters. The lead-rich metallic and slag phases were characterized by chemical analysis, SEM-EDS and XRD. In addition, the jarosite residue and the final slag were leached with an aqueous acetic acid solution to estimate their chemical stability. The results show a recovery of over 95% of the lead and silver and the formation of an environmentally friendly residual slag.