bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases
Authors: Zhang Qiong , Guo Man , Xu Chao , Lei Hong , Zhou Jie , Zhu Chun-Yu , Li Fei-feng , Liu Shu-Lin
Published: December 2019

Background: Cerebral infarction is one of the most common cerebral small vessel diseases. Many angiogenesis relevanted factors have special roles on the diseases pathogenesis. The vascular endothelial growth factor A (VEGFA) is the most prominent stimulating molecule factor for angiogenesis. So, we want to evaluate the correlation between VEGFA gene and this disease in this work. Methods: The VEGFA gene was sequenced for 400 cerebral infarction patients and 600 normal controls. SPSS software (version 19.0), Plink (version 1.9), Haploview software and online software SNPSpD were used for the statistical analyses and Hardy-Weinberg equilibrium tests. Results: We found variants rs10434, rs3025040, rs185218985, rs199971699, rs574579489, rs735286 and rs833061 within or near the VEGFA gene. The genetic heterozygosity of rs10434, rs3025040, rs735286 and rs833061 was very high. Statistical analysis showed that the variants rs10434 (P=0.041) and rs735286 (P=0.034) in the gene were associated with the risk of cerebral infarction diseases in the Chinese Han population. Conclusions: VEGFA variants rs10434 and rs735286 were associated with the risk of cerebral infarction diseases in the Chinese Han population.
Examination of a nationwide cohort of individuals with high health literacy in terms of their health-related lifestyles and attainment of the goals of the “National Health Promotion in the 21st Century” Program
Authors: Hirooka Nobutaka , Sano Takeshi , Yasumura Reiko , Maeyama Yuji , Nakamoto Hidetomo
Published: December 2019

Background: In Japan, where the population is aging particularly rapidly, “healthy aging” is being advocated as a means of addressing the potential societal burdens caused by older adults’ need for nursing care and the high associated health-care costs. To improve healthy aging among the population, the Japanese government has launched the “National Health Promotion in the 21st Century” (HJ21), which contains goals concerning areas such as lifestyle behavior and use of preventive medicine. Low health literacy is associated with many health-related issues; however, whether individuals with high health literacy are meeting the HJ21 goals has not yet been examined. This study aims to determine whether a cohort with high health literacy are meeting such goals, and to compare the cohort’s performance with the national average. Methods: This is a cross-sectional survey study. Study participants, sourced from all prefectures in Japan, were professional specialists in health management certified by the Japanese Association of Preventive Medicine for Adult Disease. We measured data concerning the cohort’s demographic information, health perception, lifestyle (including physical activity) and use of preventive medicine. Results: The cohort showed many characteristics of high health literacy. The cohort had an overall healthy lifestyle and met most of the HJ21 goals; in particular, a high proportion underwent health-maintenance exams and cancer screenings. Conclusions: The high health literacy cohort showed a healthy lifestyle. Compared to the national average, a higher proportion of the cohort met the HJ21 goals and received preventive medicine.
A Study of Internet Addiction and Its Effects on the Mental Health of Medical Students: A Cross-Sectional Study in Western Iran
Authors: Lebni Javad Yoosefi , Toghroli Razie , Sharma Manoj , Mahaki Behzad , Gilan Hadi Darvishi , Kianipour Neda , Chaboksavar Fakhreddin , Moradi Farideh , Ziapour Arash
Published: December 2019

Background: The internet itself is a harmless technology. However, its overuse and misuse will expose its users to internet addiction. On the other hand, diagnosis of students’mental dysfunction is of prime importance, and their progress and academic success in the future can be prevented by this technology if not properly handled. Methods: In this descriptive and correlational study, the statistical population consisted of all students at Kermanshah University of Medical Sciences, of which 447 students studying in the first and second semesters of the academic year 2017-18 were selected through Cochran's Sample Size Formula and Stratified Random Sampling. As for data collection, the Young's Internet addiction Test (IAT) and Goldberg General Health Questionnaire (GHQ-28) were utilized. Moreover, for data analysis, the descriptive statistics (percentage, mean, standard deviation) and inferential statistics (T-test, Pearson correlation coefficient, and multiple regression analysis) were employed in the environment of SPSS Statistical Software Version 23.0. Results: The results of the present study demonstrated that the total mean score of students’ internet addiction and mental health measured 3.81±0.88 and 2.56±0.33, respectively. The results also indicated that internet addiction correlared positively with depression whereas negatively with mental health (P<0.001). Besides, the results of multiple regression analysis revealed that the five major predictors of vulnerability to internet addictionin university students were as follows: the key reason for using the internet, faculty, depression, the main place for using the internet, and somatic symptoms. Conclusions: According to the findings of the present study, it can be concluded that students’ excessive use of the internet leads to depression, anxiety, and reduced mental health, thereby affecting their academic performance. Hence, it is suggested that further monitoring and control be exercised on how the internet is used by university students, and they should be informed of the detrimental effects of this technology in the case of misuse or overuse.
Prevalence and Associated Factors of Thinness among Adolescent Students in Finoteselam Town, Amhara Region, Ethiopia
Authors: Mengesha Damitie Kebede , Prasad Reddy P. C. J. , Asres Degnet Teferi
Published: December 2019

Background Adolescence is the period of intense physical, psychosocial and cognitive development and the second to infancy at which highest rate of physical growth occur. So, adolescents need to have good quantity and quality nutrient to cope with this rapid growth and other health risk which increase nutritional demand. This study aimed to assess the prevalence and associated factors of thinness among school adolescents in Finoteselam town, Amhara region, Ethiopia.Methods A school-based cross-sectional study among adolescent students aged 10-19 in public primary and secondary schools was carried out in Finoteselam town from February 05 to March 27, 2018. A total of 397 adolescent students were included in the study. Stratified and simple random sampling techniques were employed to select study subjects. Pre tested structured questionnaires were used to collect the data. Data was entered using Epi info version 7 and analyzed using SPSS version 20 and WHO Anthro Plus soft ware. A multivariate logistic regression analysis was employed to identify factors associated with stunting. Crude and adjusted odds ratios with 95% level significance were used to measure the strength of association and statistical significance was declared at p-value less than 0.05.Results The prevalence of thinness among adolescents was 14.9%. Early Adolescent stage (AOR= 4.81; 95% CI: 1.23, 18.51), being Male adolescent students (AOR = 2.33; 95% CI: 1.60, 3.40), and using well water (AOR= 3.82; 95% CI: 1.46, 10.04) were significantly associated with thinness at P-value <0.05.Conclusion The study revealed that prevalence of thinness was high in the study area. Age, Sex and sources of drinking water were found to be important factors associated with thinness among the respondents.
Study on the Evolution of Information Sharing Strategy for Users of Medical Cloud
Authors: Zhu Panpan , Shen Jiang , Xu Man
Published: December 2019

Technological advances are driving the growth of online health communities. However, there are some problems such as low user participation and insignificant social benefits in online health communities. This paper discusses the evolution law of information sharing behavior of members of online health community to study the influence of different behaviors on health information sharing results and explore the ways to improve the level of community information sharing. Based on BA scale-free network (Albert-László Barabás and Réka Albert scale-free network) , this paper established an information sharing behavior model for members of online health community with the evolutionary game theory method, and discussed the influence of different game parameters and initial conditions on the evolution results of information sharing behavior of community patients with the method of numerical experiment.Results: It is found that the key to improve the level of community information sharing is to improve the benefit of patients' information sharing, the proportion of patients sharing information at the initial moment, the degree of network nodes, and reduce the sharing cost. Community managers should improve the information conversion ability and information absorption ability of community patients through offline activities, professional guidance and other forms. At the same time, it can reduce the difficulty and risk of information sharing and strengthen the connection among members, thus comprehensively enhancing the value of the community.
Financial Institutions Micro Loans: A Strategy for Reducing Poverty in Nigeria
Authors: Popoola M. Ak. , Brimah Am. N. , Gbadeyan A. R.
Published: December 2019

This article summarizes the arguments and counter-arguments in the scientific debate on the use of microcredit by financial institutions as a strategic direction for poverty reduction in Nigeria. This study is aimed at studying the impact of microcredit operations provided by commercial banks to business entities, poverty indicators of the country. Five commercial and five microfinance banks of the state of Nigeria were selected as the object of the study. Methodological support of this work includes a survey method (for accumulating primary information on obtaining correct data of respondents on the dynamics of poverty indicators, reducing unemployment, training, skills, expanding income opportunities, etc.). The article presents the results of empirical analysis, showed a significant impact of microcredit processes of financial institutions to reduce poverty indicators in Nigeria.The author notes the need for banks in Nigeria to introduce less aggressive mechanisms for profit, that is, formed on a socialist basis. Based on the results of the study, the author proposed the following recommendations: financial and institutional promotion of major microfinance banks in Nigeria; the increase in government spending on the organization of seminars to prepare and expand business opportunities for community representatives to establish their own business, simplification of mechanisms for the provision of microcredit (on the principles of gender sensitivity, in particular for women entrepreneurs) and reduction of interest rates for entrepreneurs, which will improve both the indicators of financial and economic development of the country, and will contribute to the well-being of society as a whole.
Keywords: financial institutions, microfinance banks, microcredit, poverty reduction.
PENGEMBANGAN PERANGKAT PERKULIAHAN FISIKA DASAR 1 DINAMIKA GERAK DENGAN PENDEKATAN DEMOCRATIC APPROACH
Authors: Poernomo Joko Budi
Published: December 2019

Penelitian ini bertujuan mengembangkan bentuk perangkat perkuliahan Fisika dengan democratic approach melalui problem posing pada Dinamika Gerak. Metode pe- nelitian adalah penelitian pengembangan perangkat pem- belajaran yang meliputi Satuan Acara Perkuliahan (SAP) dan Bahan Ajar. Draft perangkat yang dihasilkan divali- dasi oleh Dosen Mitra, Kaprodi, pakar pendidikan Fisika dan diujicobakan pada siswa di Perkuliahan Fisika Dasar 1 Tahun Akademik 2010-2011. Hasil dari penelitian ini menunjukkan bahwa penilaian  validitas isi Satuan Acara Perkuliahan para ahli 4,42; yang tergolong valid; penilain terhadap keterlaksanaan perkuliahan oleh observer 4,45; termasuk kategori baik, dan  penilain ketuntasan perkulia- han Fisika Dasar 1 mencapai 86 %, serta 88% mahasiswa memberi respon positip.
PENDIDIKAN KARAKTER DAN PENDEKATAN SETS (Science Environment Technology and Society) DALAM PERENCANAAN PEMBELAJARAN SAINS
Authors: L Listyono
Published: December 2019

Pengertian karakter menurut Pusat Bahasa Depdiknas adalah “bawaan, hati, jiwa, kepribadian, budi pekerti, perilaku, personalitas, sifat, tabiat, temperamen, watak”. Adapun berkara- kter adalah berkepribadian, berperilaku, bersifat, bertabiat, dan berwatak”. Menurut Tadkiroatun Musroh (UNY, 2008), kara- kter mengacu kepada serangkaian sikap (attitudes), perilaku (behaviors), motivasi (motivations), dan keterampilan (skills). Karakter berasal dari bahasa Yunani yang berarti “to mark” atau menandai dan memfokuskan bagaimana mengaplikasikan nilai kebaikan dalam bentuk tindakan atau tingkah laku, se- hingga orang yang tidak jujur, kejam, rakus dan perilaku jelek lainnya dikatakan orang berkarakter  jelek. Sebaliknya, orang yang perilakunya sesuai dengan kaidah moral disebut dengan berkarakter mulia.
MELATIH KREATIVITAS DAN DAYA NALAR SISWA MELALUI MODEL PEMBELAJARAN RME
Authors: M Mujiasih
Published: December 2019

Atas dasar ijin dari Kementerian Pendidikan Nasional, maka model pembelajaran Realistic Mathematics Education (RME) telah dilaksanakan di seluruh Indonesia. Di setiap provinsi, telah ditunjuk beberapa sekolah untuk melak- sanakan pembelajaran RME ini. Oleh karena itu, maka mahasiswa Prodi Tadris Matematika perlu disiapkan se- cara dini, dengan pengetahuan tentang model pembela- jaran RME ini, yakni mengetahui sintaks (urutan langkah pembelajaran), dan mampu mempraktikkannya. Dalam pembelajaran matematika di sekolah, ada tiga dimensi utama yang berkaitan dengan pembelajaran matematika di sekolah, yaitu (1) kegunaan matematika dalam kehidu- pan sehari-hari, (2) matematika sebagai alat berpikir, dan (3) matematika sebagai produk budaya manusia. Pembe- lajaran matematika harus mampu mengembangkan ke- mampuan siswa untuk memberikan alasan (reasoning), mengembangkan kreativitas (creativity), daya nalar (think logically), dan pembuktian (proof). Hal ini dapat dicapai me- lalui pembelajaran RME.Jadi, pembelajaran matematika di sekolah perlu dija- dikan sarana untuk melatih dan mengembangkan kreativi- tas siswa dalam kapasitasnya sebagai anggota masyarakat yang kelak akan beraktivitas dengan memerlukan kreativi- tas yang tinggi. Salah satu caranya adalah dengan mener- apkan RME (Realistic Mathematics Education) di sekolah.
PENERAPAN PEMBELAJARAN KONTEKSTUAL PADA KALKULUS 2 BAHASAN VOLUM BENDA PUTAR
Authors: Romadiastri Yulia
Published: December 2019

Salah satu bahasan pada mata kuliah Kalkulus 2 adalah aplikasi integral tentu, yang di dalamnya terdapat materi menentukan volum benda putar. Materi ini cukup sulit mengingat mahasiswa harus dapat memvisualisasikan daerah yang berupa bidang datar ke dalam ruang dimensi tiga. Selain itu, ada beberapa metode yang digunakan un- tuk menentukan volum benda sesuai dengan bentuk ban- gun ruang yang dihasilkan. Dengan menerapkan pembela- jaran kontekstual diharapkan dapat membantu mahasiswa dalam memvisualisasikan dan menentukan metode yang sesuai untuk mencari volum benda putar tersebut.
PENGGUNAAN MEDIA ANIMASI DALAM PEMBELAJARAN TRIGONOMETRI UNTUK MENINGKATKAN HASIL BELAJAR MAHASISWA TADRIS MATEMATIKA IAIN WALISONGO SEMARANG
Authors: Siswanah Emy
Published: December 2019

Trigonometri merupakan pelajaran yang bersifat abstrak. Agar ma- teri yang bersifat abstrak menjadi mudah dipahami diperlukan suatu me- dia pembelajaran. Salah satu media pembelajaran yang dapat diterapkan dalam pembelajaran trigonometri adalah media animasi. Efek animasi pada media animasi membuat media tersebut menjadi lebih menarik se- hingga mampu menarik perhatian mahasiswa. Pemanfaatan media ani- masi dalam pembelajaran dapat membangkitkan keinginan, minat, serta meningkatkan motivasi mahasiswa. Penggunaan media animasi mampu merangsang kegiatan belajar mahasiswa, membantu keefektifan proses pembelajaran, memperlancar pencapaian tujuan untuk memahami dan mengingat informasi yang diberikan. Selain itu, penggunaan media ani- masi juga dapat menjelaskan materi yang bersifat abstrak menjadi konkret sehingga membantu mahasiswa dalam memahami pelajaran trigonometri. Hal ini berakibat pada meningkatnya hasil belajar mahasiswa pada kelas yang pembelajarannya menggunakan media animasi. Dengan demikian penggunaan media animasi dapat meningkatkan hasil belajar mahasiswa Tadris Matematika IAIN Walisongo Semarang.
Item in dependability: definition and content of the concept
Authors: Netes V. A.
Published: December 2019

Aim.The paper continues the series of publications that investigate and discuss the essence and definitions of the basic concepts of the dependability theory. It analyzes the basic concept, which is the subject of consideration in dependability, for which the term “item” is usually used. The concept of “dependability” is defined for it, and in general all the terminology of dependability applies to it. The following issues are considered: how to name and define this subject of consideration, what it can be, what can be its constituents. In particular, the relationship between the concepts of “item” and “product” is discussed.

Methods.The evolution of definitions of this concept in the Russian and international terminological standards in dependability over the past 30 years is traced. A comparative analysis of other standards and federal laws relating to items of different types is carried out. The viability of two main ways of getting an idea of a concept is considered: illustrative (based on examples) and definitional (by means of sequential definition of some concepts through others).

Findings and conclusions.The definition and correct understanding of the concept of “item” is of great importance, as it affects the scope of dependability standards. It is explained why it is necessary to accept that the definitions of the basic concepts cannot be rigorously formalized and are in fact only explanations. It is shown that the definitions of the item in the existing Russian and international standards (GOST 27.002–2015 and IEC 60050-192:2015) have inaccuracies. To eliminate them, improved notes to the definition of an item are proposed. The first note lists the possible types of items: products (parts, assembly units, complexes) and their components; buildings and structures; systems consisting of jointly functioning products and structures and their subsystems. The second note indicates the relationship between the main constituents of the item: hardware, software and people (personnel), and their possible combinations. The paper provides reasons for considering virtual items that play an important role in today’s information and telecommunication technologies and are logically isolated subsystems within the systems that they are part of. Besides that, it points out the deficiencies in the definitions of various items in GOST 18322–2016.
Mining machines accident problem solving via the Toyota A3 Report
Authors: Papić Ljubia , Gadolina I. V. , Panteli Milorad , Papić Neda
Published: December 2019

The Aim of the paper is to show the advantages associated with the application of the Toyota A3 Report as a standard method of information exchange. It must be noted that as of today this method has not found widespread application. It deserves better. Using specific examples of accidents involving mining machines, the authors show how a Report is completed hoping that this information will help in the adoption of this system in other enterprises. That may contribute to the solution of many problems of industrial management. This paper will be most useful for operators of mining machines.

TheMethodconsists in presenting material on an А3 sheet of paper, that is required in order to set forth all the information needed to solve a problem. Why the А3 format? A3 is the maximum size of a sheet of paper that can be faxed. Before the emergence of personal computers it was the most common tool of communication between Toyota Motor factories. The above example of application of the Toyota A3 Report contains such crucial sections as maintenance and reliability of mining machines, information on prior research, application of the “5 Why?” method and consideration of the human factor. In the example given in the paper, the report describes the circumstances of the accident involving the SRs 1200 24/4 (G2) excavator, that occurred on April 6, 1995 in the open-pit mine Field D, mining basin Kolubara by the Electric Power Industry of Serbia. The report also includes an estimate of the consequences and analysis of the causes of the accident.

TheFindingsinclude the methodological approach to the solution of problems, brief format of information presentation, documentation and registration, so that other people involved in the process can review it; assuring the persons involved can form an idea of the operating procedures and outcome of problem resolution. A common language is provided for communication within the company along with a culture of Lean production. The А3 Report is a training process and foundation for future changes in the manufacturing process management.

Conclusions.The Toyota A3 Report has two primary functions: submission of proposals and reporting on the approved measures per the submitted proposals. It allows strictly defining the problem and proceeding to the measures aimed at improving the situation. The practical application of the Report as part of communication within the company and with suppliers will enable quick and targeted solution of managerial problems. Initially developed in Japan within the Toyota company, the method currently finds wider application in Serbian enterprises and elsewhere.
Methods for Reducing Contrast Use and Avoiding Acute Kidney Injury During Endovascular Procedures
Authors: Vergadis Chrysovalantis , Festas Georgios , Spathi Eleni , Pappas Paris , Spiliopoulos Stavros
Published: December 2019

:

Iodinated Contrast Media (CM) has a plethora of applications in routine non-invasive or percutaneous invasive imaging examinations and therapeutic interventions. Unfortunately, the use of CM is not without complications, with contrast-induced acute kidney injury (CI-AKI) being among the most severe.

:

CI-AKI is a syndrome defined as a rapid development of renal impairment after a few days of CM endovascular injection, without the presence of any other underlying related pathologies. Although mostly transient and reversible, for a subgroup of patients with comorbidities related to renal failure, CI-AKI is directly leading to longer hospitalization, elevated rates of morbidity and mortality, as well as the increased cost of funding.

:

Thus, a need for classification in accordance with clinical and peri-procedural criteria is emerged. This would be very useful for CI-AKI patients in order to predict the ones who would have the greatest advantage from the application of preventive strategies.

:

This article provides a practical review of the recent evidence concerning CI-AKI incidence, diagnosis, and sheds light on prevention methods for reducing contrast use and avoiding AKI during endovascular procedures.

:

In conclusion, despite the lack of a specific treatment protocol, cautious screening, assessment, identification of the high-risk patients, and thus the application of simple interventions -concerning modifiable risk factors- can significantly reduce CI-AKI risk.
Anti-inflammatory Constituents from Eurycoma longifolia Roots
Authors: Chau Nguyen Minh , Tuan Ha Manh , Hung Tran Manh , Dat Nguyen Tien , Dang Nguyen Hai
Published: December 2019

Eight secondary metabolites (1-8) were isolated from the roots of Vietnamese Eurycoma
longifolia. The structures of these compounds were elucidated using a variety of spectroscopic methods.
Among the compounds was eurylongilactone A (1), a new oxygenated C20 quassinoid with a
11β,20-epoxy bridge. The anti-inflammatory activities of the compounds were evaluated against LPSinduced
NO production in RAW264.7 cells. Compound 1 and ethyl ferulate (8) had the strongest inhibitory
effects, with IC50 values of 3.03 ± 0.73 and 3.56 ± 0.43 µM, respectively. Compounds 2, 4,
and 7 had moderate activity.
Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes
Authors: Cheng Yi , Zhang Runmei , Lu Tianhao , Shen Yong , Wang Min , Xie Chunsong
Published: December 2019

Under mild conditions, C3-quaternary 2H-pyrrolines can be convergently and efficiently assembled
by Cu(II) and weak bases cocatalyzed [3+2] cycloaddition of 1,1-disubstituted alkenes and
isocyanoacetates. Various functionalities can be tolerated, affording 2H-pyrrolines with up to two quaternary
centers in a single step.
Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity
Authors: Nallathamby Neeranjini , Phan Chia-Wei , Sova Matej , Saso Luciano , Sabaratnam Vikineswary
Published: December 2019

Background:

Microglia are associated with neuroinflammation, which play a key role
in the pathogenesis of neurodegenerative diseases. It has been reported that some quinazolines and
quinazolinones possess anti-inflammatory properties. However, the pharmacological properties of
certain quinazoline derivatives are still unknown.

Objective:

The antioxidant, cytotoxic, and protective effects of a series of synthesized 2-
trifluoromethylquinazolines (2, 4, and 5) and quinazolinones (6-8) in lipopolysaccharide (LPS)-
murine microglia (BV2) and hydrogen peroxide (H2O2)-mouse neuroblastoma-2a (N2a) cells were
investigated.

Method:

The antioxidant activity of synthesized compounds was evaluated with ABTS and DPPH
assays. The cytotoxic activities were determined by MTS assay in BV2 and N2a cells. The production
of nitric oxide (NO) in LPS-induced BV2 microglia cells was quantified.

Results:

The highest ABTS and DPPH scavenging activities were observed for compound 8 with
87.7% of ABTS scavenge percentage and 54.2% DPPH inhibition. All compounds were noncytotoxic
in BV2 and N2a cells at 5 and 50 μg/mL. The compounds which showed the highest protective
effects in LPS-induced BV2 and H2O2-induced N2a cells were 5 and 7. All tested compounds,
except 4, also reduced NO production at concentrations of 50 μg/mL. The quinazolinone
series 6-8 exhibited the highest percentage of NO reduction, ranging from 38 to 60%. Compounds
5 and 8 possess balanced antioxidant and protective properties against LPS- and H2O2-induced cell
death, thus showing great potential to be developed into anti-inflammatory and neuroprotective
agents.

Conclusion:

Compounds 5 and 7 were able to protect the BV2 and N2a cells against LPS and
H2O2 toxicity, respectively, at a low concentration (5 μg/mL). Compounds 6-8 showed potent reduction
of NO production in BV2 cells.
Benzazole Substituted Iminocoumarins as Potential Antioxidants with Antiproliferative Activity
Authors: Perin Nataša , Cindrić Maja , Vervaeke Peter , Liekens Sandra , Mašek Tomislav , Starčević Kristina , Hranjec Marijana
Published: December 2019

Background:

Benzazole and coumarin derivatives are one of the most privileged heterocyclic substructures in the medicinal chemistry with well-known biological features, which include a wide range of versatile biological activities as well as excellent spectroscopic characteristics thus offering their potential application in many research fields.

Objective:

The prepared iminocoumarins were synthesized to evaluate their antioxidative potential by using ABTS and FRAP assays and in vitro antiproliferative activity.

Method:

A series of coumarin derivatives containing a 2-benzazole motif were synthesized and evaluated for their antioxidative capacity and antiproliferative activity. Their molecular structure incorporates a push-pull functionality: an electron donor donating group at the 7-position with an electron-withdrawing group, such as benzimidazole, benzothiazole and imidazopyridine fragment at the 3-position.

Results:

The iminocoumarins bearing different substituents on 7-position were evaluated for their antiproliferative activity on tree cancer cells with only 4 compounds showing the antiproliferative activity. The most active derivative was N,N-diethylamino substituted benzimidazole derivative 4d and imidazo[4,5-b]pyridine analogue 6b, both also displayed selective activity toward CEM with submicromolar inhibitory concentration (0.059 μM; 0.17 ± 0.09, respectively). The inhibitory effect of 4d and 6b derivatives on the cell-cycle progression of HeLa cells was studied. A flow cytometric analysis of the HeLa cells indicated an appreciable cell-cycle arrest in a dose-dependent manner. Antioxidant properties were studied by ABTS and FRAP assays and obtained results revealed that the most promising antioxidant has proven to be compound 3b while other compounds, in general, showed moderate to very low antioxidative capacity in both assays.

Conclusion:

Unsubstituted benzimidazole derivatives bearing hydroxyl group on iminocoumarin nuclei exhibited the most prominent antioxidant potential in ABTS assay (3b; 40.5 ± 0.01). The most significant and selective antiproliferative activity was displayed by compounds 4d and 6b (0.059 μM; 0.17 ± 0.09, respectively), which were chosen as lead compounds for further optimization and rational design to obtain more active and selective antiproliferative agents.
Wound Healing Management: A Systematic Approach Of Existing Treatment
Authors: Khan Azmi , Chaudhary Manupriya , Gupta Madhu
Published: December 2019

:

Wound healing is an elaborated and vastly synchronized process that requires intricate coordination between many cell types with an appropriate extracellular microenvironment. The management of wounds represents a key research area due to the vital functional and aesthetic role of this tissue. An auspicious approach in the currently available treatment is the growth factors that imitate the micro environs and active vital regenerative pathways conducive to wound healing. An organized methodology to study, a multi-expert methodology to treatment and enthusiasm to study the patient’s perceptions are some of the principal amendments that have paralleled technical advances and know-how such as debridement, Negative Pressure Therapy, natural drugs etc. These methodologies may be seen as co-operative in wound healing. This article will review pathophysiology, discuss currently available treatment and novel approaches for treating a wound.
Low Complexity Adaptive Nonlinear Models for the Diagnosis of Periodontal Disease
Authors: Satpathy Anurag , Panda Ganapati , Gogula Rajasekhar , Sharma Renu
Published: December 2019

Background / Objective:

The paper addresses a specific clinical problem of diagnosis of periodontal disease with an objective to develop and evaluate the performance of low complexity Adaptive Nonlinear Models (ANM) using nonlinear expansion schemes and describes the basic structure and development of ANMs in detail.

Methods:

Diagnostic data pertaining to periodontal findings of teeth obtained from patients have been used as inputs to train and validate the proposed models.

Results:

Results obtained from simulations experiments carried out using various nonlinear expansion schemes have been compared in terms of various performance measures such as Mean Absolute Percentage Error (MAPE), matching efficiency, sensitivity, specificity, false positive rate, false negative rate and diagnostic accuracy.

Conclusion:

The ANM with seven trigonometric expansion scheme demonstrates the best performance in terms of all measures yielding a diagnostic accuracy of 99.11% compared to 94.64% provided by adaptive linear model.
An Enhanced Multiple Linear Regression Model for Seasonal Rainfall Prediction
Authors: Shaker Reddy Pundra Chandra , Sureshbabu Alladi
Published: December 2019

Aims & Background:

India is a country which has exemplary climate circumstances
comprising of different seasons and topographical conditions like high temperatures, cold atmosphere,
and drought, heavy rainfall seasonal wise. These utmost varieties in climate make us exact
weather prediction is a challenging task. Majority people of the country depend on agriculture.
Farmers require climate information to decide the planting. Weather prediction turns into an orientation
in farming sector to deciding the start of the planting season and furthermore quality and
amount of their harvesting. One of the variables are influencing agriculture is rainfall.

Objectives & Methods:

The main goal of this project is early and proper rainfall forecasting, that
helpful to people who live in regions which are inclined natural calamities such as floods and it
helps agriculturists for decision making in their crop and water management using big data analytics
which produces high in terms of profit and production for farmers. In this project, we proposed
an advanced automated framework called Enhanced Multiple Linear Regression Model (EMLRM)
with MapReduce algorithm and Hadoop file system. We used climate data from IMD (Indian
Metrological Department, Hyderabad) in 1901 to 2002 period.

Results:

Our experimental outcomes demonstrate that the proposed model forecasting the rainfall with
better accuracy compared with other existing models.

Conclusion:

The results of the analysis will help the farmers to adopt effective modeling approach by
anticipating long-term seasonal rainfall.
Outage Analysis in Underlay OFDMA Based Cooperative Cognitive Radio Networks
Authors: Sawant Rupali , Nema Shikha
Published: December 2019

Background:

Efficient resource allocation in Cooperative Cognitive Radio Network
(CCRN) is necessary in order to meet the challenges in future wireless networks. With proper resource
allocation, the Quality of Service (QoS) comprising of outage probability and data rate are
evaluated in this paper and sufficiently improved with proper subcarrier allocation.

Objective:

Another important parameter is Signal to Interference Ratio (SIR) which should be
above a threshold called minimum protection ratio to maintain the required QoS.

Results:

The network considered is Orthogonal Frequency Division Multiple Access (OFDMA)
based Hybrid Cooperative Cognitive Radio Network (HCCRN) in downlink in which licensed as
well as unlicensed resources are used by cognitive user depending on it’s availability keeping the
interference constraint in limit. The number of subcarriers required is different for every user depending
upon its distance from the base station to satisfy the requirement of data rate which depends
on the experienced SIR. To avoid outage of users at the boundary of a cell, it is necessary to
allocate more number of subcarriers.

Conclusion:

It is observed that for a given user position and outage probability, as the number of
subcarrier allocation in a subchannel increases high data rates can be achieved. This analysis can
be useful in allocation of subcarriers to users depending upon their position.
Scalability Analysis of Privacy Enabled IPv6 Addressing Protocol for Duty Cycled 6LoWPAN
Authors: Mavani Monali , Asawa Krishna
Published: December 2019

Background:

The privacy enabled IPv6 addressing mechanism ensures the privacy of the
node's identification in the communication messages. It makes it difficult for adversaries to track nodes
and link any activities with the node's IP or the MAC address. Scalability of the privacy enabled IPv6
addressing scheme for 6LoWPAN may be affected due to underlying MAC layer mechanisms.

Objective:

Hence, this study aims to explore such an impact.

Methods:

Addressing scheme is implemented in the Contiki operating system which uses duty cycling
at the MAC layer along with the CSMA channel access mechanism. ContikiMAC and
CXMAC are widely used duty cycling protocols in Contiki. An analytical study is presented in
this paper, which analyses the IPv6 address configuration delay with ContikiMAC and CXMAC.
Simulation is performed to corroborate the presented analytical model. The address configuration
latency limits the scalability of the network. Hence, this paper studies the impact of duty cycling
of the nodes on the address configuration latency and estimates the size of a single hop PAN.

Results & Conclusion:

It is observed that the ContikiMAC duty cycling protocol can achieve better
performance compared to the CXMAC protocol in terms of address configuration latency. In
order to make up for the delay due to duty cycling, the network can be divided into multiple PANs
of smaller sizes where the addressing process runs simultaneously.
Enantiomeric Separation of Meclizine Hydrochloride in Pharmaceutical Dosage Form by HPLC Method
Authors: Gowramma Byran , Kumar Ramachandran Senthil , Kalirajan Rajagopal , Lakshmanan Kaviarasan , Meyyanathan Subramanian Nainar
Published: December 2019

Objective:

A basic, powerful and isocratic chiral fluid chromatographic technique was created and approved for the enantiomeric partition of meclizine hydrochloride in pharmaceutical dose structure.

Methods:

The chromatographic partition was accomplished on Phenomenex® Lux Cellulose 1 (250 mm x 4.6 mm i.d, 5 μm molecule size) section utilizing portable stage framework containing acetonitrile: 25mM ammonium bicarbonate (75:25%v /v). The versatile stage was siphoned on the segment at the stream pace of 1.0 mL/min, and UV recognition was done at 230 nm.

Result:

The breaking points of recognition and measurement were observed to be 0.25 μg/mL and 1.00 μg/mL individually, for 20μL infusion volume. The alignment bend demonstrated phenomenal linearity over the focus scope of 1-5 μg/mL for (±) meclizine enantiomers with a relationship coefficient (r2 = 0.999). The recuperation investigation of meclizine from tablet plan was observed to be 97.33% and 98.81% separately. Meclizine standard arrangement and versatile stage were observed to be steady for in any event 32h. The meclizine enantiomers were very much settled with mean maintenance times of about (+) Meclizine at 13.14 min and (-) Meclizine at 14.33 min individually.

Conclusion:

The created technique was broadly approved and demonstrated to be hearty, exact, exact and appropriate for the examination of meclizine enantiomers in tablet measurement structure and security investigations of meclizine.
A Comparative Review for Question Answering Frameworks on the Linked Data
Authors: Tasar Ceren O. , Komesli Murat , Unalir Murat O.
Published: December 2019

Background:

One of the state-of-the-art techniques for question answering frameworks is
using linked data by converting the user input into SPARQL which is the query language for linked
data.

Objective:

The main target is to emphasize the most fundamental issues while developing a question
answering frameworks that accept input in natural language and converting it into SPARQL.

Methods:

The trend of applying linked data as a data source is gaining popularity among the researchers.
In this study, question answering frameworks that combine both natural language processing
techniques and linked data technologies are examined. Common principles of examined
question answering frameworks recognize user intention, enriching natural language input and converting
it to a SPARQL query.

Results:

9 studies are selected for further examination to be compared by using selection criteria defined
in the research methodology.

Conclusion:

Resulting outcomes are represented and compared in detail. In addition to the comparative
review of systems, a general architecture of question answering frameworks on the linked data
is drawn as an outcome of this study to provide a guideline for the researchers who are studying related
research fields.
Growth rates of valuable tree species in secondary tropical montane cloud forests in Mexico: influence of tree size, crown position and competition
Authors: Mendoza-Hernández Magdaleno , Gerez-Fernández Patricia , Purata-Velarde Silvia , Toledo-Aceves Tarin
Published: December 2019

Tropical montane cloud forests (TMCF) are under severe threat from deforestation, fragmentation and degradation. Several tree species are harvested and commercialized by local communities through unplanned selective logging. Lack of information regarding the growth rates of the most economically valuable timber species hampers the design of effective sustainable management schemes for TMCF. The objective of this study was to determine the diameter growth rates and evaluate the influence of tree size, crown class and neighbouring tree basal area on the growth of common and valuable TMCF timber species. Annual diameter growth was measured during two years in 60 trees (10 to 45 cm in diameter at breast height; dbh) each of Alnus acuminata, Liquidambar styraciflua and Quercus xalapensis, located in two unmanaged secondary TMCF sites in Veracruz, Mexico. High diameter growth rates (centimeter per year [cm yr-1]; mean ± SE) were recorded in the three species; the highest was recorded in A. acuminata (1.62 cm yr-1 ± 0.08 cm yr-1), followed by Q. xalapensis (0.91 cm yr-1 ± 0.07 cm yr-1) and L. styraciflua (0.71 cm yr-1 ± 0.08 cm yr-1). Diameter growth rate was inversely related to the basal area of the neighbouring trees, indicating a negative effect of competition in the three species. Dominant trees had higher growth rates than supressed trees in the three species. The high growth rates recorded in forests with no previous management and the negative effect of basal area of neighbouring trees support the potential for silvicultural management in secondary TMCF.
Kazania bożonarodzeniowe
Authors: Jungiewicz Anna , Panuś Kazimierz
Published: December 2019

Niniejszy tom pozwala zapoznać się z kazaniami przybliżającymi tematykę Bożego Narodzenia, obecnymi w kulturze polskiej od wielu stuleci. Najstarszy tekst pochodzi z końca XIII wieku, najmłodszy – z początku XXI wieku. Okres Bożego Narodzenia rozpoczyna się w Wigilię od pierwszych nieszporów Narodzenia Pańskiego, a kończy wraz z drugimi nieszporami niedzieli Chrztu Pańskiego obchodzonej po 6 stycznia. To właśnie w tym czasie, trwającym około trzech tygodni, uwaga Kościoła koncentruje się na tajemnicy narodzenia Jezusa Chrystusa i Ewangelii Dzieciństwa aż do chrztu Zbawiciela i rozpoczęcia przez Niego publicznej działalności. Dominantę tego okresu stanowią dwie uroczystości: Narodzenia Pańskiego (25 grudnia) z następującą po niej oktawą oraz Epifanii – Objawienia Pańskiego (6 stycznia), nazwana przez św. Augustyna „bliźniaczą uroczystością” (geminata sollemnitas). To pierwsze historycznie święto związane z tajemnicą wcielenia zwane jest często w Polsce świętem Trzech Króli. Wszystkie zamieszczone w tomie teksty starają się ukazać okoliczności wejścia w rodzinę ludzką Syna Bożego i odpowiedzieć na doniosłe pytanie, dlaczego Bóg staje się człowiekiem.
Frekuensi Nafas dan Pulsus Ular Sanca Batik (Malayopython reticulatus) Lokalitas Jawa
Authors: Raharjo Slamet , Hartati Sri , Indarjulianto Soedarmanto , Widayanti Rini
Published: December 2019

Reticulated python (Malayopython reticulatus) java locality is highly demand as pet animal. Respiratory and pulse rate were important physiological data needed for diagnostic references. The aim of this research was to study the repiratory and pulse rate on Java M. reticulatus. Thirthy healthy adult Java M. reticulatus were used in this study. The respiratory rate recorded by counting inspiratory and expiratory movement of the thorax for one minute and pulse rate recorded by heart palpation for one minute, measured at 6-8 AM and at 4-6 PM for five consecutive days. Temperature and humidity were record as secondary data. The data were analyzed using independent t-Test. The respiratory rate in this study recorded in the morning ranged 5-48 breaths/minute averaging 20 breaths/minute and in the evening ranged 7-49 breaths/minute averaging 24 breaths/minute. The pulse rate in the morning ranged 21-68 beats per minute (bpm) averaging 45.5 bpm and in the evening ranged 40-82 bpm averaging 56 bpm. Totally, M. reticulatus having the respiratory rate 5-49 breaths/minute and pulse rate 21-82 bpm. The morning temperature ranged 25-27oC and the evening 26-27.5oC. The range of morning and evening air humidity is 66-75% and 65-70% respectively. The results showed that the comparison of respiratory rate (R) and pulse rate (P) were in normal range namely 1:2.25 in the morning and 1:2.33 in the evening. There were no significant differences (P>0.05) between morning and evening respiratory rate and no significant effect (P>0.05) of temperature and humidity on respiratory and pulse rate. It could be concluded that healthy adult Java M. reticulatus has a respiratory rate 5-49 breaths/minute dan pulse rate 21-82 bpm.
Deteksi Kejadian Residu Tetrasiklin pada Daging Ikan Nila di Kota Yogyakarta dengan Kromatografi Cair Kinerja Tinggi (KCKT)
Authors: Pawestri Wari , Satria Gagak Dhony , Hakimah Nisa , Yudhabuntara Doddi
Published: December 2019

Food products of animal origin which are free from biological and chemical contamination are an absolute requirement of food safety. Antibiotics residues in the food of animal origin is one of the chemical contaminants in food are harmful/hazardous to human health. Tetracycline is an antibiotic that is often used in the fishing industry. The study aims to detect the occurrence of tetracycline residues in tilapia sold in traditional markets in Kota Yogyakarta. The research was conducted with detection test (detect disease). The study used 61 samples of tilapia fish from 16 traditional markets in Kota Yogyakarta. Tilapia meat samples are prepared according to the Association of Official Analytical Chemistry (AOAC). The existence of tetracycline residues in meat can be detected by high performance liquid chromatography (HPLC). Residue analysis in fish meat was conducted at the Department of Pharmacology, Faculty of Veterinary Medicine of Gadjah Mada University using HPLC Shimadzu version 6.1. The results showed that 24 samples of tilapia meat marketed in Kota Yogyakarta was positively contained tetracycline antibiotic residues. A total of 19 samples contained residues above maximum residue limits (MRL). The conclusion of the study is 31% of tilapia marketed in Kota Yogyakarta contains tetracycline residues above MRL. Surveillance of residues in food of animal origin and further research in terms of reducing antibiotic residue in tilapia meat is highly recommended to improve the quality and safety of food of animal origin.