bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacologic strategies to prevent hemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy
Authors: Yoon Sang Won , Kang Hyun , Choi Geun Joo
Published: December 2019

Background:

Hypertensive disorders of pregnancy are major health issues affecting mothers and infants. General anesthesia is inevitable for certain mothers with these conditions and they may exhibit pronounced hemodynamic instability, especially during induction and airway manipulation. The aims of this study are to combine direct and indirect comparisons of the efficacies of different medications used in attenuating reflex hemodynamic responses and generate intervention ranking by network meta-analysis (NMA).

Methods:

A systematic and comprehensive search will be performed using MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar databases, beginning from their inceptions to November 2019. Only randomized clinical trials evaluating the efficacy and safety of pharmacologic interventions for preventing hemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy will be included. The primary endpoints will be maximal mean arterial pressure (MAP) and maximal heart rate after intubation. Maximal systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and maternal/fetal blood gas analysis, as well as safety issues, including Apgar score at 1 minute and 5 minutes after delivery, will be also assessed.

We will conduct both pairwise meta-analysis and network meta-analysis. We will use surface under the cumulative ranking curve (SUCRA) values and rankograms to present the hierarchy of pharmacologic interventions. A comparison-adjusted funnel plot will be used to assess the presence of small-study effects. The quality of the studies included will be assessed using the risk of bias tool 2.0. All statistical analyses will be performed using Stata SE, version 15.0 (StataCorp, College Station, TX).

Results:

The results of this systematic review and NMA will be published in a peer-reviewed journal.

Conclusion:

This NMA will enable us to determine the order of effectiveness and safety of pharmacological interventions used in attenuating hemodynamic responses for mothers with hypertensive disorders of pregnancy.

Trial registration number:

CRD42019136067.
Meta-analysis of influences of Biejiajian Pill combined with entecavir on serum liver fibrosis markers of compensatory period of hepatitis b cirrhosis
Authors: Zhang Tianyao , Yang Yu , Wang Baojia , Zheng Xiuli , Wang Long , Feng Xianrong , Li Guiyu , Shi Jinyu , Cao Ning
Published: December 2019

Background:

Chronic viral hepatitis b and its related complications have caused serious harm to human health and become a worldwide public health problem. Hepatitis b cirrhosis is one of the most common complications in Asia. Traditional Chinese medicine combined with antiviral therapy has become the first choice for clinical treatment of hepatitis b Cirrhosis. Biejia Pill is an effective prescription of traditional Chinese medicine in treating Compensatory period of cirrhosis, and there are more and more clinical reports about its validity in treating Compensatory period of cirrhosis. Therefore, we designed this study protocol to evaluate the adjuvant role of Biejia Pill in the treatment of Compensatory period of cirrhosis.

Method:

Electronic Databases, PubMed, EMBASE database, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang, Chinese Scientific Journals Database (VIP) and China Biology Medicine disc, (CBM), will be systematically searched from inception to July 2019. Randomized controlled trials (RCTs) on Biejiajian Pill combined with Entecavir and Entecavir alone against Compensatory period of hepatitis b cirrhosis will be included; inclusion and exclusion criteria will be used to screen the trials. liver fibrosis biomarkers including ECM or its metabolites (serum hyaluronic acid (HA), laminin (LN), procollagen type III (PC-III), and type IV collagen (IV-C)) will be measured as primary outcomes. Liver function, including alanine aminotransferase (ALT) and aspartarte aminotransferase (AST), and improvement of related clinical symptoms will be measured as secondary outcomes. RevMan5 software will be used for literature quality evaluation and data synthesis and analysis.

Result:

To evaluate the efficacy and safety of Biejiajian Pill in combination therapy by observing the outcomes of serum liver fibrosis markers, adverse reactions and liver function.

Conclusion:

This study protocol will be used to evaluate the efficacy and safety of Biejia Pill in combination with entecavir in the treatment of Compensatory period of hepatitis b cirrhosis, as well as the adjuvant treatment of Biejia Pill in combination.

PROSPERO registration number: CRD42019135402
Chart review of patients receiving valsartan–amlodipine single-pill combination versus valsartan and amlodipine combination for blood pressure goal achievement and effects on the Hamilton anxiety rating/Hamilton depression rating scales
Authors: Yin Gang , Li Yuefan , Xu Wenjie , Han Na
Published: December 2019

This study aimed to compare the Hamilton anxiety rating/Hamilton depression rating (HAMA/HAMD) scale scores and blood pressure (BP) goal achievement associated with the use of valsartan–amlodipine single-pill combinations (SPCs) versus valsartan and amlodipine combination in adult hypertensive patients.

A total of 476 hypertensive patients were randomly assigned into the SPC (valsartan–amlodipine) and control (valsartan and amlodipine combination) groups. All patients had an uncontrolled BP (160–179/100–109 mm Hg). BP goal was <140/90 mm Hg. Cox proportional hazards regression analysis was used to analyze the likelihood of HAMA/HAMD scales, SPCs, control group, and daily dosage number. Kaplan–Meier analysis was used to estimate the rates of BP goal achievement over time among the 2 groups.

A total of 476 patients were included in the study, and 439 patients completed the follow-up and received the index drug therapy. There was a significant difference in BP between the 2 groups on days 28, 42, and 56. Patients who received SPCs had a significantly higher rate of BP goal achievement over time (P = .000). The average HAMD scores in the SPC and control groups were 5.54 and 5.49 and 6.06 and 6.21 on days 28 and 56, respectively. The average HAMA scores in the SPC and control groups were 7.41 and 7.13 and 7.90 and 8.01 on days 28 and 56, respectively. The means of HAMD and HAMA scores were 5.826 and 7.614, respectively. The higher the HAMA/HAMD scores, the lower was the BP goal achievement. The number of drugs taken by the patients was associated with the HAMA and HAMD scores. There was no significant difference between HAMA scores of patients taking 1 tablet daily (7.22 ± 1.885) and those taking two-tablets daily (7.38 ± 1.953) (P = .408). However, when these scores were compared to those of patients taking 4 tablets daily (8.08 ± 2.285), a significant difference was observed (P = .000, P = .000).

Hypertensive patients treated with valsartan–amlodipine SPCs were significantly more likely to achieve BP goal and have lesser HAMA/HAMD scores compared to patients treated with valsartan and amlodipine combination.
National physician survey on glycemic goals and medical decision making for patients with type 2 diabetes
Authors: Laiteerapong Neda , Ham Sandra A. , Nathan Aviva G. , Sargis Robert M. , Quinn Michael T. , Huang Elbert S.
Published: December 2019

To describe how patient characteristics influence physician decision-making about glycemic goals for Type 2 diabetes.

2016 survey of 357 US physicians. The survey included two vignettes, representing a healthy patient and an unhealthy patient, adapted from a past survey of international experts and a factorial design vignette that varied age, heart disease history, and hypoglycemia history. Survey results were weighted to provide national estimates.

Over half (57.6%) of physicians recommended a goal HbA1c <7.0% for most of their patients. For the healthy patient vignette, physicians recommended a goal similar to that of international experts (<6.66% (95% Confidence Interval (CI), 6.61–6.71%) vs <6.5% (Interquartile range (IQR), 6.5–6.8%)). For the unhealthy patient, physicians recommended a lower goal than international experts (<7.38% (CI, 7.30–7.46) vs <8.0% (IQR, 7.5–8.0%)). In the factorial vignette, physicians varied HbA1c goals by 0.35%, 0.06%, and 0.28% based on age, heart disease history, and hypoglycemia risk, respectively. The goal HbA1c range between the 55-year-old with no heart disease or hypoglycemic events and the 75-year-old with heart disease and hypoglycemic events was 0.65%.

Despite guidelines that recommend HbA1c goals ranging from <6.5% to <8.5%, US physicians seem to be anchored on HbA1c goals around <7.0%.
Effect of target-controlled propofol infusion to reduce the incidence of adverse events for procedural sedation in the emergency department: a systematic review
Authors: Burton Fiona M. , Lowe David J. , Millar Jonathan E. , Corfield Alasdair R. , Watson Malcolm J. , Shaw Martin , Sim Malcolm A.B.
Published: December 2019

The administration of propofol target-controlled infusion (TCI) for procedural sedation is standard in a range of hospital settings except for the Emergency Department (ED). Propofol TCI could be an alternative, safer way to provide procedural sedation in the ED compared with other methods of propofol administration. We compare the incidence of adverse events using propofol TCI compared with other methods of propofol administration. We conducted a systematic review of the literature from 1946 to January 2019 identifying studies that compared propofol TCI with other propofol regimens for procedural sedation in the adult population. Studies were assessed for risk of bias using the Cochrane Collaboration risk of bias tool. Seven articles were included. There was significant methodological heterogeneity in all aspects of study designs and definitions of adverse events which precluded a meta-analysis. A systematic review of the studies demonstrated fewer respiratory and cardiovascular adverse outcomes in three of the seven studies. It was not possible to determine if propofol TCI reduces the incidence of adverse events when compared with other sedating regimens using propofol using a descriptive systematic review of the relevant literature. Further research is required to compare the incidence of adverse events using propofol TCI for procedural sedation with other methods of administration in the ED. Future systematic reviews and meta-analysis comparisons would be aided by the use of standard adverse event reporting tools such as that of the Society of Intravenous Anaesthesia.
Characteristic Radiological Features of Retrospectively Diagnosed Pancreatic Cancers
Authors: Fukushima Daizo , Nishino Noriyuki , Hamada Koichi , Horikawa Yoshinori , Shiwa Yoshiki , Nishida Shinya , Koyanagi Ryota , Abe Tsuyoshi , Suzuki Nobuyasu , Takano Yoshinao , Teranishi Yasushi , Munechika Hirotsugu , Miura Yoshihiro , Nakasato Tatsuhiko , Sakuma Hideo
Published: December 2019

Objectives

The aim of this study was to assess the characteristic radiological features of early-stage pancreatic cancer (PC).

Methods

Between 2009 and 2016, 510 PC patients were selected from our hospital cancer registry database based on International Classification of Diseases for Oncology-3 (C25). Among them, 64 patients (42 males and 22 females; median age, 74 [range, 59–91]) had received repeated abdominal radiological examinations before their diagnosis of PC and were retrospectively investigated for specific radiological findings. The subjects underwent the following imaging examinations: computed tomography, magnetic resonance imaging, and fluoroglucose–positron emission tomography.

Results

Characteristic radiological features before diagnosis of PC were classified into the following 9 features: pancreatic duct ectasia (n = 16), focal low-density area (n = 15), change of cyst size (n = 8), localized tissue atrophy (n = 7), distal atrophy (n = 4), mass in pancreatic lipomatosis tissue (n = 2), mass concomitant with the already known cyst (n = 2), protrusion (n = 1), and parenchymal disproportion (n = 1). Fifty-three cases (84%) had more than one characteristic radiological feature before diagnosis of PC, and their median observation period until diagnosis was 24 (range, 1–120) months.

Conclusions

The 9 characteristic radiological features provide an opportunity to diagnose PC at an early stage.
Timely Reduction of Triglyceride Levels Is Associated With Decreased Persistent Organ Failure in Hypertriglyceridemic Pancreatitis
Authors: Lu Zhihua , Li Man , Guo Feng , Zhang Ge , Song Shuping , Liu Nan , Wang Donghai
Published: December 2019

Objectives

The aim of the study was to examine the relationship between the reduction of serum triglycerides (TGs) and the severity of disease in patients with hypertriglyceridemic pancreatitis (HTGP).

Methods

A retrospective study was conducted among patients with HTGP. Serum TGs measured on admission (TG0), 24 hours after admission (TG24), and 48 hours after admission (TG48) were compared between patients with and without persistent organ failure (POF). Multivariable analysis determined whether elevated TG levels were independently associated with POF.

Results

A total of 242 patients were included, of which 62 patients (25.6%) developed POF. Patients who developed POF had higher TG levels of TG0, TG24, and TG48 than those without POF (all P < 0.05). Patients with earlier TG levels of less than 5.65 mmol/L were proportionally less likely to develop POF (P
trend = 0.002). On multivariate analysis, TG48 of 5.65 mmol/L or more was independently associated with POF (odds ratio, 3.316; 95% confidence interval, 1.256–8.755; P = 0.016).

Conclusions

Timely reduction of serum TGs during the early phase of HTGP is proportionally associated with decreased development of POF. Serum TG levels by 48 hours of admission correlate independently with POF.
Genomic Characterization of HPV-related and Gastric-type Endocervical Adenocarcinoma: Correlation With Subtype and Clinical Behavior
Authors: Hodgson Anjelica , Howitt Brooke E. , Park Kay J. , Lindeman Neal , Nucci Marisa R. , Parra-Herran Carlos
Published: December 2019

The majority of endocervical adenocarcinomas (EAs) are caused by human papillomavirus (HPV). Gastric-type EA, the second most common EA and unrelated to HPV, is biologically different with a more aggressive clinical course. Our knowledge of the molecular fingerprint of these important EA types and its role in diagnosis, prognosis and management is still evolving. Thus, we sought to evaluate the genomic profile of HPV-related and gastric EA. Clinical information including patient outcome was gathered for 56 tumors (45 HPV-associated and 11 gastric-type) surveying evaluated by a targeted massively parallel sequencing assay (OncoPanel platform) which surveys exonic DNA sequences of 447 cancer genes and 191 regions across 60 genes for rearrangement detection. KRAS, TP53, and PIK3CA were the most commonly mutated genes (10, 10, and 9 cases, respectively). Alterations in TP53, STK11, CDKN2A, ATM, and NTRK3 were significantly more common in gastric-type EA (P<0.05, Fisher exact test). Disease recurrence and/or death occurred in 14/49 (29%) cases with clinical information available 7 HPV-related (18% of HPV-related cases with clinical information available) and 7 gastric-type (64% of gastric-type cases with clinical information available). Tumors associated with adverse outcome, regardless of histotype, more commonly had alterations in KRAS (2 HPV-related, 4 gastric-type), GNAS (3 HPV-related, 1 gastric-type), and CDKN2A (0 HPV-related, 3 gastric type) compared with indolent-behaving cases (P<0.05, Fisher exact test). A total of 8/56 (14%) tumors harbored at least one actionable mutation; of these, 6 (75%) were associated with recurrence and/or cancer-related death. Copy number variations were detected in 45/56 cases (80%). The most frequent were chromosome 20 gain and 16q loss, identified in 7 cases each (all HPV-associated EA). The mutational profile of EA is diverse and correlates with clinical behavior and EA subtype. Thus, targeted sequencing assays can potentially serve as a diagnostic and prognostic tool. It can also identify targetable alterations, which may benefit patients with recurrent/metastatic disease.
Assessing Patient Satisfaction and Experience With an Electronic Referral Process
Authors: Mohammed Heba Tallah , Huebner Lori-Anne
Published: December 2019

Background and Objectives:

Our study aimed to identify patients' perception of an eReferral process and e-mail notification system.

Methods:

Patients within the Waterloo Wellington Local Health Integration Network who registered their e-mail address with physicians who adopted the eReferral system, and therefore received e-mail notifications of their booked appointment, were invited to complete an online satisfaction survey. This patient experience survey is an ongoing online link embedded within the confirmation e-mail of the booked appointment. The survey is hosted on the eReferral solution platform and has been operational since November 2017. The survey consists of 8 questions with 3 main categories to assess patients' opinion of their experience of the referral process and notification system using a 5-point Likert scale and open-ended questions.

Results:

A total of 545 patients have completed the patient satisfaction survey within this reporting period with a response rate of 15%. In general, 94% of patients agreed that receiving a confirmation e-mail of their booked appointment had improved their experience with the referral process. The majority (94%) agreed that the eReferral process was easy to follow, and 83% agreed that they were able to get the care they needed within a reasonable time. Compared with their past referral experiences, 80% of patients felt more informed throughout this electronic referral process. Using binominal logistic regression, participants whose preferences were considered had 8.06 times higher odds to exhibit satisfaction with the referral process than those who did not. Patients' qualitative responses identified the eReferral process as being quick, efficient, and resulting in a sense of being in control of their own health care. There are some limitations to the system felt by some of the patients who responded to the open-ended questions of the survey. Patients identified the need to add a complementary structure to the notification design consisting of multiple dates and times with a chance to pick the appointment that suits patients best instead of being restricted to only 1 appointment date. A few patients thought that the heading of the e-mail notification system should be more distinguishable for easier tracking. Furthermore, some patients felt the need to add some notes to the initial e-mail advising patients of the next steps throughout their referral process.

Conclusion:

eReferral has improved patients' experience with the referral process. Our findings in this study would support the solution vendor in its efforts to refine and enhance active communication channels with patients for sustainable health care that meets patients' expectations and needs.
Short Face Dentofacial Deformities: Changes in Social Perceptions, Facial Esthetics, and Occlusion After Bimaxillary and Chin Orthognathic Correction
Authors: Posnick Jeffrey C. , Ogunsanya Oluremi , Singh Neeru , Kinard Brian E.
Published: December 2019

The purpose of this study was to document changes in social perceptions and facial esthetics, and document occlusion outcomes in a series of short face (SF) dentofacial deformity (DFD) subjects. The investigators hypothesized that subjects would achieve positive change in social perceptions and facial esthetics, and maintain a long-term corrected occlusion after undergoing bimaxillary and chin osteotomies.

A retrospective cohort study was implemented. Photographic records and occlusion parameters were studied preoperatively and >2 years after surgery. The first outcome variable was social perceptions of SF subjects, judged by laypersons. The second outcome variable was facial esthetics, judged by professionals. The third outcome variable was occlusion maintained long-term.

Fifteen subjects met inclusion criteria. Mean age at operation was 33 years. Consistent facial contour deformities at presentation included deficient maxillary dental show and downturned oral commissures. As a group, there was improvement (P < 0.05) in 11 of 12 social perceptions, judged by laypersons, all subjects achieved correction of the facial esthetic parameters studied by professionals, and all subjects maintained a favorable occlusion long-term.

In SF DFD subjects, bimaxillary and chin surgery proved effective to improve social perceptions, to correct facial contour deformities, and in achieving a long-term corrected occlusion.
Multi-Domain Translation between Single-Cell Imaging and Sequencing Data using Autoencoders
Authors: Yang Karren Dai , Belyaeva Anastasiya , Venkatachalapathy Saradha , Damodaran Karthik , Radhakrishnan Adityanarayanan , Katcoff Abigail , Shivashankar GV , Uhler Caroline
Published: December 2019

The development of single-cell methods for capturing different data modalities including imaging and sequencing have revolutionized our ability to identify heterogeneous cell states. While various methods have been proposed to integrate different sequencing data modalities, coupling imaging and sequencing has been an open challenge. We here present an approach for integrating vastly different modalities by learning a probabilistic coupling between the different data modalities using autoencoders to map to a shared latent space. We validate this approach by integrating single-cell RNA-seq and chromatin images to identify distinct sub-populations of human naive CD4+ T-cells that are poised for activation. Collectively, our approach provides a framework to integrate and translate between data modalities that cannot yet be measured within the same cell for diverse applications in biomedical discovery.
Drug-induced decreased urine output predicts PDA closure in preterm neonates
Authors: Goel Malika , Dutta Sourabh , Saini Shiv Sajan , Sundaram Venkataseshan
Published: December 2019

Objective

Prostaglandin inhibitors (PGI) are used to treat patent ductus arteriosus (PDA) of prematurity. PGIs often cause decrease in urine output (UO), the mechanism of which is like that of PDA closure. We hypothesized that PGI-induced decrease in UO predicts PDA closure.

Design

Prospective, cohort

Setting

Level III NICU

Methods

We prospectively enrolled 40 preterm neonates (≤34 weeks gestation) with clinical and/or echocardiographic hemodynamically significant PDA (hsPDA), being treated with Ibuprofen or Paracetamol. We measured UO, weight, total fluid intake (TFI) at baseline and daily until 72 h. We performed echocardiogram at baseline and daily until PDA closure or end of treatment. We compared “PDA-closed” and “PDA-open” groups for change in UO, weight and TFI from baseline.

Results

“PDA-closed” and “PDA-open” groups had 28 and 12 neonates respectively. Median (Q1, Q3) percent decrease in UO was greater in “PDA-closed” vs “PDA-open” group: from baseline to 0-24 h [-44.87% (−54.79%, +0.04%) vs −15.03% (−27.91%, +49.11%)]; to 24-48 hours [-40.85% (−52.81%, +14.45%) vs. −2.57% (−24.82%, +61.73%) and to 48-72 hours [-32.77% (−49.4%, +32.22%) vs. +20.74% (−6.88%, +98.39%). “PDA closed” group had significantly greater percent decrease in weight by 72-h. Mixed linear model showed that “group” and “time” were independently associated with UO; but “group*time” interaction and covariates (echocardiographic hsPDA, weight, gestation, postnatal age) were not. Decrease in UO of 27% and 17% by 24-48 h and 48-72 h respectively, best predicted PDA closure.

Conclusions

Transient decrease in UO after treating hsPDA with a PGI may predict successful closure of PDA.
Gender score development in a retrospective approach in the Berlin Aging Study II
Authors: Nauman A. Tauseef , Behlouli Hassan , Alexander Nicholas , Kendel Friederike , Drewelies Johanna , Mantantzis Konstantinos , Berger Nora , Wagner Gert G. , Gerstorf Denis , Demuth Ilja , Pilote Louise , Regitz-Zagrosek Vera
Published: December 2019

In addition to biological sex, gender, the sociocultural dimension of being a woman or a man, plays a central role in health. However, there are so far no approaches to quantify gender in a retrospective manner in existing study datasets. We therefore aimed to develop a methodology that can be retrospectively applied to assess gender in existing cohorts. We used baseline data from the Berlin Aging Study II (BASE-II), obtained in 2009-2014 from 1869 participants aged 60 years and older. We identified 13 gender related variables and used them to construct a gender score (GS) by primary component and logistic regression analysis. Of these, 9 variables contributed to a gender score: chronic stress, marital status, risk taking behavior, agreeableness, neuroticism, extraversion, loneliness, conscientiousness, and education. GS differed significantly between females and males as defined by sex. Next, we calculated linear regressions to investigate associations between sex, GS, and selected biological and well-being variables. Sex, but not GS was significantly associated with LDL-C and TC. GS, but not sex, was significantly associated with cortisol levels, CES-depression, negative affect, life satisfaction. Thus, we were able to develop a GS in a retrospective manner from available study variables that characterized women and men in addition to biological sex. This approach will allow us to introduce the notion of gender retrospectively into a large number of studies.
Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction
Authors: Sgrignani Jacopo , Cecchinato Valentina , Fassi Enrico M.A. , D’Agostino Gianluca , Garofalo Maura , Danelon Gabriela , Grazioso Giovanni , Uguccioni Mariagrazia , Cavalli Andrea
Published: December 2019

During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. HMGB1 and the chemokine CXCL12, both released in the microenvironment, form a heterocomplex, which exclusively acts on the chemokine receptor CXCR4, enhancing cell migration and, in some pathological conditions such as Rheumatoid Arthritis, exacerbating the immune response. An excessive cell influx at the inflammatory site can be diminished by disrupting the heterocomplex.

Here, we report the computationally driven identification of a novel peptide (HBP08), which binds HMGB1 with the highest affinity reported so far (Kdof 0.8 ± 0.1 μM), able to selectively inhibit the activity of the CXCL12/HMGB1 heterocomplex.

The identification of this peptide represents an important step towards the development of innovative pharmacological tools for the treatment of severe chronic inflammatory conditions characterized by an uncontrolled immune response.
Cognitive computing on unstructured data for customer co-innovation
Authors: Chen Sixing , Kang Jun , Liu Suchi , Sun Yifan
Published: December 2019

Purpose

This paper aims to build on the latest advances in cognitive computing techniques to systematically illustrate how unstructured data from users can offer significant value for co-innovation.

Design/methodology/approach

The paper adopts a general overview approach to understand how unstructured data from users can be analyzed with cognitive computing techniques for innovation. The paper links the computerized techniques with marketing innovation problems with an integrated framework using dynamic capabilities and complexity theory.

Findings

The paper identifies a suite of methodologies for facilitating company co-innovation via engaging with customers and external data with cognitive computing technologies. It helps to expand marketing researchers and practitioners’ understanding of using unstructured data.

Research limitations/implications

This paper provides a conceptual framework that divides co-innovation process into three stages, ideas generation, ideas integration and ideas evaluation, and maps cognitive computing methodologies and technologies to each stage. This paper makes the theoretical contributions by developing propositions from both customer and firm perspectives.

Practical implications

This paper can be used for companies to engage consumers and external data for co-innovation activities by strategically select appropriate cognitive computing techniques to analyze unstructured data for better insights.

Originality/value

Given the lack of systematic discussion regarding what is possible from using cognitive computing to analyze unstructured data for co-innovation. This paper makes first attempt to summarize how unstructured data can be analyzed with cognitive computing techniques. This paper also integrates complexity theory to the framework from a novel perspective.
Community cultural wealth and literacy capital in Latin American communities
Authors: Trigos-Carrillo Lina
Published: December 2019

Purpose

The purpose of this paper is to investigate the literacy practices of the families and communities of first-generation college students in Latin America, and how community and family literacies can inform the understanding of first-generation college students’ identity and cultural values.

Design/methodology/approach

This transnational ethnography was conducted in local communities around three public universities in Mexico, Colombia and Costa Rica. Participants included nine fist-generation college students and more than 50 people in their families and communities (i.e. relatives, parents and friends). Data gathering occurred at the university outside the formal space of the classroom, at home, and in the community. Data were interpreted through the lens of the community cultural wealth framework.

Findings

The author found that first-generation college students and their families and communities engaged in rich literacy practices that have been overlooked in policy, research, and media. It is argued that the concept literacy capital is necessary to acknowledge the critical literacy practices communities engage in. Literacy capital was manifested in these communities to preserve cultural traditions, to sponsor literacy practices and to question and resist unjust sociopolitical circumstances.

Practical implications

The findings of this study should inform a culturally sustaining pedagogy of academic literacies in higher education. Beyond asset-based approaches to academic literacies in Latin America, critical perspectives to academic literacies teaching and learning are needed that acknowledge the Latin American complexities.

Originality/value

These findings are significant because they unveiled how people in local communities were informed about the sociopolitical dynamics at the national and international scale that affected or even threatened their local culture, and how they used their literacy capital to react critically to those situations.
Determinants of intention to use Islamic banking
Authors: Ayyub Samia , Xuhui Wang , Asif Muhammad , Ayyub Rana Muhammad
Published: December 2019

Purpose

This paper aims to explore the determinants of intention to use Islamic banking and compare the consumer behavior of users and non-users of Islamic banking. This study incorporates the theory of planned behavior in Islamic banking perspective with an additional construct from technology acceptance model.

Design/methodology/approach

The research is quantitative in nature, and survey questionnaire was used to get data from four cities of Pakistan. The study manages to get 300 questionnaires from which only 264 were usable for analysis. The structural equation modeling was used for testing the hypotheses.

Findings

The result shows that perceived behavior control and perceived usefulness are the most significant predictors of intention to use of Islamic banking among users and non-users. Attitude turns out to be a non-significant factor for non-users of Islamic banking. Subjective norm is also found to be non-significant with intention to use Islamic banking in both groups.

Originality/value

This study has theoretical as well as practical significance in the subject of consumer behavior in Islamic banking. Theoretically, it attempts to fill the gap caused by the scarcity of research in exploring the consumer behavior towards Islamic banking in Pakistan. This study provides insights into the consumer behavior of users and non-users of Islamic banking and thus presents a comparison. Practically, this study provides guidelines for Islamic banks in introduction, propagation and promotion of Islamic banking products and services to establish Islamic banking as a social norm.
Firm characteristics, innovation, financial resilience and survival of financial institutions
Authors: Nkundabanyanga Stephen Korutaro , Mugumya Elizabeth , Nalukenge Irene , Muhwezi Moses , Najjemba Grace Muganga
Published: December 2019

Purpose

The purpose of this paper is to examine the relationship among firm characteristics, innovation, financial resilience and survival of financial institutions in Uganda.

Design/methodology/approach

This paper employs a cross-sectional research design, and responses from 143 officers of 40 financial institutions are analyzed using Statistical Package for the Social Sciences. The authors used ordinary least squares regression in testing the hypotheses.

Findings

The authors find that firm characteristics of size, age, innovation and financial resilience have a predictive force on survival of public interest firms such as financial institutions.

Research limitations/implications

The implication drawn here is that a combination of firm characteristics, firm innovation and financial resilience explains a significant contribution in the survival chances of financial institutions. However, as much as firm characteristics and financial resilience are significant, innovation explains more of the variances in financial institutions’ going concern appropriateness.

Originality/value

This paper adds to the limited financial institutions literature and provides the first empirical evidence of the efficacy of innovation and financial resilience on financial institutions survival. The auditing profession could consider more seriously the innovation activities and financial resilience of financial institutions in their test for the going concern assumption of such firms.
A review of Industry 4.0 in supply chain management studies
Authors: Chauhan Chetna , Singh Amol
Published: December 2019

Purpose

The purpose of this paper is to assess how the emergent theme of Industry 4.0 is considered in the context of supply chain management (SCM) and to identify important areas for future research.

Design/methodology/approach

A systematic literature review of 334 studies is carried out. The papers have been analyzed by having a focus on the unit of analysis, research methods used, the key themes covered and how the debate has evolved over a period of time.

Findings

Findings of the study reveal that scholars have so far focused on principles and practices for digitized SCM, identified enablers and barriers, and considered the Industry 4.0 at various levels, particularly at the firm level. Majority of studies focus on manufacturing from the perspective of the focal firm.

Research limitations/implications

Limitation of this study is its unit of analysis where only peer-reviewed journal and conference articles published in the English language have been considered.

Practical implications

This review identifies the important themes and areas for practitioners to consider vis-à-vis the implementation of Industry 4.0 standards in supply chains. The review provides insights into under-researched areas and highlights the need for future researchers to develop more practical models for guiding the implementation of Industry 4.0.

Originality/value

This paper is one among the few studies that assess the Industry 4.0 implementation in the context of SCM and provides insights and implications for further research.
Tourism planning: a perspective paper
Authors: Costa Carlos
Published: December 2019

Purpose

The purpose of this paper is to analyse past tourism planning and discuss how it is going to evolve in the future.

Design/methodology/approach

The paper is based on literature review, but it also advances a model for future tourism planning.

Findings

The paper demonstrates that there is a strong need for tourism planning to be carried out with close links between territorial planning and its economics and management.

Research limitations/implications

The paper is not based on primary data collection.

Practical implications

The paper is useful for planners, academics and practitioners. It shows how a new planning model may be put in practice in the future.

Social implications

By linking physical and economic planning, the paper has good management implications to involve people and make them benefit from tourism.

Originality/value

Most tourism models fail to associate physical and economic planning, while this paper brings an innovative perspective of doing this.
Ecological and economic benefits of low‐intensity urban lawn management
Authors: Watson Christopher J. , Carignan‐Guillemette Léonie , Turcotte Caroline , Maire Vincent , Proulx Raphaël
Published: December 2019

Intensive management of urban lawns is globally widespread, predominantly for aesthetic reasons. However, a growing body of knowledge demonstrates negative ecological and environmental effects of this practice.

We present a meta‐analysis of North American and European studies from 2004 to 2019, which incorporates three previously unpublished datasets from eastern Canada, to investigate how mowing intensity impacts the ecology of urban lawns.

The meta‐analysis provides aggregated evidence that invertebrate and plant diversity is lower in urban lawns under increased mowing intensity. This decline is independent of the level of contrast between mowing ‘treatment’ and ‘control’ (e.g. height or frequency of mowing), which differed considerably between studies. Intensive mowing also increases the occurrence of pest species (e.g. herbivorous beetle larvae and allergenic plants), though studies in this group were limited to northern environments. Changes in ecosystem‐level variables (soil temperature, soil moisture deficit and carbon deficit) were less evident and suggest changes in abiotic processes may take longer to become apparent.

An economic case study of the mowing costs in Trois‐Rivières, Canada, suggests that cost savings of 36% may be possible with a modest reduction of mowing frequency.

Synthesis and Applications. Increasing urban biodiversity and reducing greenhouse gas emissions are strong motivators for reducing lawn management intensity. We also suggest that the benefits of reducing pest species while saving lawn management costs may provide additional social and economic incentives for decision makers to review urban greenspace management practices.
Variation in the production of plant tissues bearing extrafloral nectaries explains temporal patterns of ant attendance in Amazonian understorey plants
Authors: Nogueira Anselmo , Baccaro Fabricio B. , Leal Laura C. , Rey Pedro J. , Lohmann Lúcia G. , Bronstein Judith L.
Published: December 2019

Information on direct and indirect drivers of temporal variation in ant–plant interactions is scarce, compromising our ability to predict the functioning of these ecologically important interactions.

We investigated the roles of precipitation, ant activity, abundance of young plant tissues bearing extrafloral nectaries (EFNs) and EFN phenotypes in the establishment of EFN‐mediated ant–plant interactions throughout the year in Amazonia, Brazil. We hypothesized that the frequency of ant–plant interactions follows a predictable seasonal pattern, being higher in wetter periods, during which plants invest more in the production of new plant tissues bearing EFNs, ultimately promoting ant attendance. We surveyed and tagged every understorey Bignonieae plant rooted inside 28,500‐m2plots, and recorded ant–EFN interactions on each plant five times throughout the year. We also sampled ants with honey baits to estimate temporal variation in general ant activity.

Contrary to our hypothesis, the proportion of plants tended by ants in each plot was higher in drier, not wetter, months. Ant attendance was indirectly and negatively related to precipitation, which was attributed to a decrease in the proportion of plants producing new EFN‐bearing plant tissues during the wetter period. Additionally, seasonal variation in an ant activity did not explain temporal patterns of plant attendance. At the plant level, ant attendance increased strongly with the number of recently formed shoot nodes, and ants almost never attended plants with limited or no young tissue. Among the 12 most abundant Bignonieae species, the amount of young tissue was the most important predictor of ant attendance, secondarily explained by the EFN secretory area.

Synthesis. Our results suggest that seasonal variation in the production of new plant tissues bearing EFNs is the primary driver of the temporal patterns of EFN–plant attendance by ants in this system. Contrary to our expectations, production of new plant tissue is higher in the drier months of the year, which in turn boosts the frequency of interactions between ants and EFN‐bearing plants in the dry season. These results highlight the role of plant phenology in the remarkable variation encountered in ant visitation to EFN‐bearing plants in both space and time.
LRRC52‐AS1 is associated with clinical progression and regulates cell migration and invasion in papillary thyroid cancer
Authors: Zhou Yuying , Xiang Jingjing , Bhandari Adheesh , Wen Jialiang , Lin Bangyi , Kong Lingguo , Wang Ouchen
Published: December 2019

The incidence of thyroid cancer has increased in recent decades. The potential molecular mechanisms of papillary thyroid cancer (PTC) are still to be uncovered. In recent years, a number of studies reported that LRRC super family members are up‐regulated in cancer cells. Cancer cells can experience a feature change from an epithelial to a mesenchymal phenotype, which is called epithelial–mesenchymal transition (EMT) during cancer progression. We found that LRRC52‐AS1 is highly expressed in PTC cell lines rather than normal tissues and this observation was consistent with The Cancer Genome Atlas (TCGA) cohort. In a word, LRRC52‐AS1 is associated with clinical progression in papillary thyroid cancer. In vitro experiments showed that knocking down LRRC52‐AS1 significantly decreased the migration and invasion of the PTC cell lines (BCPAP and TPC). Meanwhile, LRRC52‐AS1 may influence the progress of papillary thyroid cancer via mesenchymal markers N‐cadherin, vimentin and TAZ. The LRRC52‐AS1 gene is up‐regulated in papillary thyroid cancer, and knockdown of LRRC52‐AS1 could restrain cellular migration, and invasion in vitro. This study indicated that LRRC52‐AS1 is a gene associated with PTC and might become a potential therapeutic target in PTC.
Herbarium specimens provide historical evidence of Cardiaspina jerramungae (Hemiptera: Psylloidea, Aphalaridae) outbreaks on Eucalyptus occidentalis in the Lower Great Southern of Western Australia
Authors: Farr Janet D
Published: December 2019

In 1982, a new species of psyllid, Cardiaspina jerramungae, reached outbreak levels on Eucalyptus occidentalis. The primary host species grows in remnant stands in the Lower Great Southern region of Western Australia and until this event was not recognised to be associated with insect outbreaks. Herbarium specimens, a largely unexploited source of data for temporal and spatial history of ecological interactions between plant hosts and insect herbivores, provided evidence of historical insect outbreaks. Evidence of C. jerramungae was traced through herbarium specimens of the preferred hosts, E. occidentalis and Eucalyptus utilis. The earliest evidence of this insect was found on a 1901 specimen of E. occidentalis. There was also evidence of a high population in 1960. Further outbreaks of C. jerramungae are likely, with consequences for the health of its primary host, although their periodicity and duration are unpredictable.
Associations between home literacy environment, brain white matter integrity and cognitive abilities in preschool‐age children
Authors: Hutton John S. , Dudley Jonathan , Horowitz‐Kraus Tzipi , DeWitt Tom , Holland Scott K.
Published: December 2019

Aim

Caregiver‐child reading is advocated by health organisations, citing cognitive and neurobiological benefits. The influence of home literacy environment (HLE) on brain structure prior to kindergarten has not previously been studied.

Methods

Preschool‐age children completed assessments of language (EVT‐2, CTOPP‐2 Rapid Object Naming) and emergent literacy skills (Get Ready to Read!, The Reading House) followed by diffusion tensor imaging (DTI). Parents completed a survey of HLE (StimQ‐P2 READ), which has four subscales. DTI measures included axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD) and fractional anisotropy (FA).

Results

Forty‐seven children completed DTI (54 ± 7 months, range 36‐63; 27 girls). StimQ‐P2 READ scores correlated with higher EVT‐2, GRTR and TRH scores, controlling for age and gender (P < .01), and also with lower AD, RD and MD in tracts supporting language and literacy skills, controlling for age, gender and income (P < .05, family‐wise error corrected). Correlations were strongest for the Bookreading Quantity subscale, including with higher scores on all cognitive measures including CTOPP‐2, and also with higher FA in left‐lateralised literacy‐supporting tracts, controlling for age, gender and income.

Conclusion

More nurturing home reading environment prior to kindergarten may stimulate brain development supporting language and literacy skills, reinforcing the need for further study.
Bayesian machine learning to discover Bruton’s tyrosine kinase inhibitors
Authors: Wang Jian , Ran Ting , Chen Yadong , Lu Tao
Published: December 2019

Bruton's tyrosine kinase (BTK) has a crucial role in multiple cell signaling pathways including B‐cell antigen receptor (BCR) and Fc receptor (FcR) signaling cascades, which has attracted much attention to find BTK inhibitors to treat autoimmune diseases. In this work, we constructed a Bayesian classification model for virtually seeking novel BTK inhibitors, which showed good performance in terms of screening efficiency and accuracy. Through searching for several chemical libraries including Chembl_17 (1,317,484 compounds), Chembridge (103,473 compounds), and Chemdiv (700,000 compounds) using this model followed by molecular docking and activity prediction, 52 compounds with novel scaffolds were acknowledged as potential BTK inhibitors, which could be promising starting points for further exploration. This study also provided a guide to construct an efficient and effective protocol for virtual screening by integrating machine learning methods.