bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishing the impact of powerful AGN on their host galaxies
Authors: Harrison C. M. , Molyneux S. J. , Scholtz J. , Jarvis M. E.
Published: March 2021

Establishing the role of active galactic nuclei (AGN) during the formation of galaxies remains one of the greatest challenges of galaxy formation theory. Towards addressing this, we summarise our recent work investigating: (1) the physical drivers of ionised outflows and (2) observational signatures of the impact by jets/outflows on star formation and molecular gas content in AGN host galaxies. We confirm a connection between radio emission and extreme ionised gas kinematics in AGN hosts. Emission-line selected AGN are significantly more likely to exhibit ionised outflows (as traced by the [O iii] emission line) if the projected linear extent of the radio emission is confined within the spectroscopic aperture. Follow-up high resolution radio observations and integral field spectroscopy of 10 luminous Type 2 AGN reveal moderate power, young (or frustrated) jets interacting with the interstellar medium. We find that these sources live in highly star forming and gas rich galaxies. Additionally, by combining ALMA-derived dust maps with integral field spectroscopy for eight host galaxies of z ≈ 2 X-ray AGN, we show that Hα emission is an unreliable tracer of star formation. For the five targets with ionised outflows we find no dramatic in-situ shut down of the star formation. Across both of these studies we find that if these AGN do have a negative impact upon their host galaxies, it must be happening on small (unresolved) spatial scales and/or an observable galaxy-wide impact has yet to occur.
Optical properties of CSS/GPS sources
Authors: Nascimento Raquel S. , Rodríguez-Ardila Alberto , Faria Marcos F. , Marinello Murilo , Dahmer-Hahn Luis G.
Published: March 2021

In this work, we study the optical properties of 58 CSS/GPS radio sources selected from the literature in order to determine the impact of the radio-jet in the circumnuclear environment of these objects. We obtained optical spectra for all sources from SDSS-DR12 and performed a stellar population synthesis using the Starlight code. Our results indicate that the sample is dominated by intermediate to old stellar populations and there is no strong correlation between optical and radio properties of these sources.
H2 content of galaxies inside and around intermediate redshift clusters
Authors: Spérone-Longin Damien
Published: March 2021

Dense environments have an impact on the star formation rate of galaxies. As stars form from molecular gas, looking at the cold molecular gas content of a galaxy gives useful insights on its efficiency in forming stars. However, most galaxies observed in CO (a proxy for the cold molecular gas content) at intermediate redshifts, are field galaxies. Only a handful of studies focused on cluster galaxies. I present new results on the environment of one medium mass cluster from the EDisCS survey at z ˜ 0.5. 27 star-forming galaxies were selected to evenly sample the range of densities encountered inside and around the cluster. We cover a region extending as far as 8 virial radii from the cluster center. Indeed there is ample evidence that star formation quenching starts already beyond 3 cluster virial radii. I discuss our CO(3-2) ALMA observations, which unveil a large fraction of galaxies with low gas-to-stellar mass ratios.
Isolated groups of extremely blue dwarf galaxies
Authors: Bootz Vitor , Trevisan Marina , Thuan Trinh , Izotov Yuri , Krabbe Angela , Dors Oli
Published: March 2021

Interactions and mergers between dwarf galaxies are mostly gas-rich and should be marked by an intense star formation activity. But these processes, which are expected to be common at earlier times, are very difficult to observe at low redshifts. To investigate that, we look in the Sloan Digital Sky Survey (SDSS) for compact groups that contain one luminous compact galaxy (LCG) with very high specific star formation rate (sSFR) and at least two other blue galaxies. We found 24 groups that satisfy these criteria, among which 12 groups have SDSS spectroscopic data for at least 2 member galaxies. Here we want to investigate, using the tidal strength estimator Q, how interactions between neighbouring galaxies affect the sSFR and concentration of each LCG. Statistical tests reveal a correlation between Q and their sSFR, indicating that tidal forces between neighbouring galaxies might be inducing bursts of star formation in the LCGs.
Outflow signatures in Gemini GMOS-IFU observations of 5 nearby Seyfert 2 galaxies
Authors: Freitas Izabel C. , Riffel Rogemar A. , Storchi-Bergmann Thaisa
Published: March 2021

We use Gemini Multi-Object Spectrograph (GMOS) Integral Field Unit (IFU) observations of a sample of 5 bright nearby Seyfert galaxies to map their emission-line flux distributions and kinematics at a spatial resolution ranging from 110 to 280 pc. For all galaxies, the gas kinematics show two components: a rotation and an outflow component.
Direct measures of chemical abundances from stacked spectra of star-forming galaxies: Implications for the mass–metallicity–star formation rate relation
Authors: Clerici Slodkowski Katia , Vale Asari Natalia
Published: March 2021

The stellar mass–star formation rate–metallicity relation provides clues on the chemical evolution of galaxies. We revisit this relation by measuring the gas-phase metallicity using the direct method. For metal-rich galaxies this is not straightforward, because auroral emission lines sensitive the electron temperature are lost in spectral noise. In order to increase the spectral signal-to-noise ratio and detect faint auroral lines, we stack the spectra of similar galaxies. This allows us to use the direct method to obtain consistent metallicity measurements.
Investigating the properties of a galaxy group at z = 0.6
Authors: Okido Daniela Hiromi , Furlanetto Cristina , Trevisan Marina , Tergolina Mônica
Published: March 2021

Galaxy groups offer an important perspective on how the large-scale structure of the Universe has formed and evolved, being great laboratories to study the impact of the environment on the evolution of galaxies. We aim to investigate the properties of a galaxy group that is gravitationally lensing HELMS18, a submillimeter galaxy at z = 2.39. We obtained multi-object spectroscopy data using Gemini-GMOS to investigate the stellar kinematics of the central galaxies, determine its members and obtain the mass, radius and the numerical density profile of this group. Our final goal is to build a complete description of this galaxy group. In this work we present an analysis of its two central galaxies: one is an active galaxy with z = 0.59852 ± 0.00007, while the other is a passive galaxy with z = 0.6027 ± 0.0002. Furthermore, the difference between the redshifts obtained using emission and absorption lines indicates an outflow of gas with velocity v = 278.0 ± 34.3 km/s relative to the galaxy.
On the path toward a universal outflow mechanism in light of NGC 4151 and NGC 1068
Authors: May D. , Steiner J. E. , Menezes R. B.
Published: March 2021

We use near-infrared Integral Field Unit (IFU) data to analyze the galaxies NGC 4151 and NGC 1068, which have very different Eddington ratios - ˜50 times lower for NGC 4151. Together with a detailed data cube treatment methodology, we reveal remarkable similarities between both AGN, such as the detection of the walls of an “hourglass” structure for the low-velocity [Fe ii] emission with the high-velocity emission within this hourglass; a molecular outflow - detected for the first time in NGC 4151; and the fragmentation of an expanding molecular bubble into bullets of ionized gas. Such observations suggest that NGC 4151 could represent a less powerful and more compact version of the outflow seen in NGC 1068, suggesting a universal feedback mechanism acting in quite different AGN.
Feedback from central massive black holes in galaxies using cosmological simulations
Authors: Barai Paramita
Published: March 2021

Gas accretion onto central supermassive black holes of active galaxies and resulting energy feedback, is an important component of galaxy evolution, whose details are still unknown especially at early cosmic epochs. We investigate BH growth and feedback in quasar-host galaxies at z ⩾ 6 by performing cosmological hydrodynamical simulations. We simulate the 2R200 region around a 2 × 1012Mʘ halo at z = 6, inside a (500 Mpc)3 comoving volume, using the zoom-in technique. We find that BHs accrete gas at the Eddington rate over z = 9–6. At z = 6, our most-massive BH has grown to MBH = 4 × 109 Mʘ. Star-formation is quenched over z = 8–6.
NIR–IFU observations of the merger remnant NGC 34
Authors: Motter Juliana C. , Riffel Rogério , Ricci Tiago V. , Dametto Natacha Z. , Dahmer-Hahn Luis G. , Diniz Marlon R. , Riffel Rogemar A. , Pastoriza Miriani G. , Rodríguez-Ardila Alberto , Storchi-Bergmann Thaísa , Ruschel-Dutra Daniel
Published: March 2021

Understanding the interplay between the phenomena of active galactic nuclei (AGN) and starbursts remains an open issue in studies of galaxy evolution. The galaxy NGC 34 is the remnant of the merger of two former gas-rich disc galaxies and it also hosts a strong nuclear starburst. In this work, we map the ionized and molecular gas present in the nuclear regions of the galaxy NGC 34 using adaptive optics (AO) assisted near infrared (NIR) integral field unity (IFU) observations. Our main goals are to better constrain the energy source of this object and to use NGC 34 as a laboratory to probe the AGN-starburst connection in the context of galaxy evolution and AGN feeding and feedback processes.
Structure and morphology of relic galaxies in the Local Universe
Authors: Freitas Rodrigo F. , Chies-Santos Ana L. , Furlanetto Cristina , Ferrari Fabricio
Published: March 2021

Red Nugget galaxies found at high-z have analogues in the Local Universe which are called relic galaxies. Because of their proximity to Earth, the relics allow a more detailed analysis of their properties and can help us understand the formation of massive early-type galaxies, since Red Nuggets could be their first phase of formation. The main goal of this work is to characterize the structure and morphology of candidates and confirmed relic galaxies in the Local Universe to further search for similar objects observationally and within cosmological simulations.
The importance of the diffuse ionized gas for interpreting galaxy spectra
Authors: Vale Asari Natalia , Stasińska Grażyna
Published: March 2021

Diffuse ionized gas (DIG) in galaxies can be found in early-type galaxies, in bulges of late-type galaxies, in the interarm regions of galaxy disks, and outside the plane of such disks. The emission-line spectrum of the DIG can be confused with that of a weakly active galactic nucleus. It can also bias the inference of chemical abundances and star formation rates in star forming galaxies. We discuss how one can detect and feasibly correct for the DIG contribution in galaxy spectra.
Circumnuclear multi-phase gas around nearby AGNs investigated by ALMA
Authors: Izumi Takuma
Published: March 2021

Since the advent of the Atacama Large Millimeter/submillimeter Array (ALMA), more attention has been paid on the ≲100 pc scale circumnuclear disk (CND) to reveal feeding and feedback processes of active galactic nuclei (AGNs). By using cold molecular CO and atomic C0 emission line observations, we have revealed that there are multi-component gas dynamical flows around the AGN of the Circinus galaxy, which may explain the physical origin of the AGN torus. In the luminous Seyfert galaxy NGC 7469, we found that [CI](1–0) line is extraordinary bright relative to CO lines (for example J 2−1), manifesting the physical/chemical influence of the AGN on the surrounding gas in the form of X-ray dominated region (XDR).
Selection and characterisation of Red Geysers in the MaNGA survey
Authors: Ilha Gabriele S. , Riffel Rogemar , Rembold Sandro B. , Schimóia Jáderson S.
Published: March 2021

Red Geysers are quiescent galaxies that show a bi-polar outflow, but the mechanism that produces this outflow is still unclear. Using MaNGA data, we find that Red Geysers correspond to ∼1.6% of the sample of galaxies already observed by MaNGA. About ∼16% of the Red Geysers show clear evidence of Active Galactic Nuclei, as revealed by emission-line ratios.
Feeding and feedback in nuclei of galaxies
Authors: Audibert Anelise , Combes Françoise , García-Burillo Santiago , Dasyra Kalliopi
Published: March 2021

Our aim is to explore the close environment of Active Galactic Nuclei (AGN) and its connection to the host galaxy through the morphology and dynamics of the cold gas inside the central kpc in nearby AGN. We report Atacama Large Millimeter/submillimeter Array (ALMA) observations of AGN feeding and feedback caught in action in NGC613 and NGC1808 at high resolution (few pc), part of the NUclei of GAlaxies (NUGA) project. We detected trailing spirals inside the central 100 pc, efficiently driving the molecular gas into the SMBH, and molecular outflows driven by the AGN. We present preliminary results of the impact of massive winds induced by radio jets on galaxy evolution, based on observations of radio galaxies from the ALMA Radio-source Catalogue.
No evidence for quenching in quasars
Authors: Wethers Clare , Acharya Nischal , De Propris Roberto , Kotilainen Jari , Schramm Malte , Schulze Andreas
Published: March 2021

The role of quasar feedback in galaxy evolution remains poorly understood. Throughout this work, we explore the effects of negative feedback on star formation in quasar host galaxies, analysing two distinct populations of quasars. The first is a sample of high-redshift (z > 2) low-ionisation broad absorption line quasars (LoBALs) - a class of quasars hosting energetic mass outflows, in which we find evidence for prolific star formation (>750Mʘyr–1) exceeding that of non-BAL quasars at the same redshift. The second is a population of 207 low-redshift (z < 0.3) quasars, in which we find an enhancement in the SFRs of quasar hosts compared to the underlying galaxy population, with no quasars residing in quiescent hosts over the last 2Gyr. Overall, we find no evidence for galaxy-wide quenching in either population, rather we suggest that the dominant effect of quasar activity is to enhance star formation in the galaxy.
The role of internal feedback in the evolution of the dwarf spheroidal galaxy Leo II
Authors: Hazenfratz Roberto , Lanfranchi Gustavo A. , Caproni Anderson
Published: March 2021

This work aims to explore the different processes of formation and evolution of dwarf spheroidal galaxies in the Local Group analyzing internal and external feedbacks, taking Leo II as a model of parametrization due to its adequate large distance to the Milky Way, in order to minimize potential external effects. We present a discussion of the first results regarding the processes of formation and galactic evolution from the gas hydrodynamics. Combined with previous studies for other similar systems, such results have the potential to establish strong links for the elaboration of a consistent and coherent scenario of formation and evolution of the dwarf spheroidal galaxies in the Local Group.
Recent insights into massive galaxy formation from observing structural evolution (Review)
Authors: Newman Andrew B.
Published: March 2021

New observations are probing the structures and kinematics of massive galaxies at a much greater level of detail than previously possible, especially during the first half of cosmic history. ALMA data now resolve the distribution of dust and molecular gas in massive galaxies to z ˜ 5. The stellar kinematics of several massive galaxies at z ˜ 2 – 3 have been spatially resolved using gravitational lensing, providing new information on the connection between quenching and morphological transformation. Star formation histories have been reconstructed for growing samples at z ˜ 0.8–2, revealing a wide range of timescales that correlate with galaxies’ sizes and environments, providing evidence for multiple paths to quiescence. I review these and other developments and summarize the insights they have provided into massive galaxies’ evolution.
Hα plumes or arms associated with the nucleus of NGC 7020
Authors: Dottori H. , Díaz R. , Gimeno G. , Bianchi A. , Gaspar G.
Published: March 2021

We imaged the galaxy NGC 7020 with Gemini and GMOS-S interference filters centered on the Hα emission line and nearby continuum in order to detect and quantify the HII regions. Among about 200 HII regions, we detected two Hα emitting plumes or arms emerging from the galactic nucleus which, together with the nuclear emission, might indicate a process of feedback from the central region.
Ubiquitous cold and massive filaments in brightest cluster galaxies
Authors: Olivares Valeria , Salomé Philippe
Published: March 2021

The origin of the mysterious multiphase filamentary structures surrounding Brightest Cluster Galaxies (BCGs) remains unknown. We present Atacama Large Millimeter/submillimeter Array (ALMA) and Multi Unit Spectroscopic Explorer (MUSE) observations for a sample of 15 BCGs to investigate the origin and life-cycle of the gas. Those observations show clumpy and massive molecular filaments, preferentially located around the radio bubbles inflated by the active galactic nuclei (AGN). We investigate where the cold gas condenses from the intra-cluster medium, by comparing the radial extent of the filaments with predictions from numerical simulations.
The gas distribution and kinematics in the central region of the Seyfert 2 galaxy NGC 1125
Authors: Marques Johan M. , Riffel Rogemar A. , Storchi-Bergmann Thaisa , Riffel Rogério , Diniz Marlon R.
Published: March 2021

We present Gemini Near-Infrared Integral-Field Spectrograph (NIFS) observations of the inner 660 × 660 pc2 of the Seyfert 2 galaxy NGC 1125, which reveals that the emission-line profiles present two kinematic components: a narrow one (σ < 150 km s−1) due to emission of the gas in the disk and a broad component (σ > 150 km s−1) produced by a bipolar outflow, perpendicular to the galaxy’s disk.
High-redshift starbursts as progenitors of massive galaxies
Authors: Gómez-Guijarro Carlos
Published: March 2021

Starbursting dust-rich galaxies are capable of assembling large amounts of stellar mass very quickly. They have been proposed as progenitors of the population of compact massive quiescent galaxies at z ˜ 2. To test this connection, we present a detailed spatially-resolved study of the stars, dust, and stellar mass in a sample of six submillimeter-bright starburst galaxies at z ˜ 4.5. We found that the systems are undergoing minor mergers and the bulk star formation is located in extremely compact regions. On the other hand, optically-compact star forming galaxies have also been proposed as immediate progenitors of compact massive quiescent galaxies. Were they formed in slow secular processes or in rapid merger-driven starbursts? We explored the location of galaxies with respect to star-forming and structural relations and study the burstiness of star formation. Our results suggest that compact star-forming galaxies could be starbursts winding down and eventually becoming quiescent.
Quasar black hole masses and accretion rates across cosmic time
Authors: Brotherton Michael , Maithil Jaya , Myers Adam , Shemmer Ohad , Matthews Brandon , Dix Cooper , Du Pu , Wang Jian-Min
Published: March 2021

Quasar black hole masses are most commonly estimated using broad emission lines in single epoch spectra based on scaling relationships determined from reverberation mapping of small samples of low-redshift objects. Several effects have been identified requiring modifications to these scaling relationships, resulting in significant reductions of the black hole mass determinations at high redshift. Correcting these systematic biases is critical to understanding the relationships among black hole and host galaxy properties. We are completing a program using the Gemini North telescope, called the Gemini North Infrared Spectrograph (GNIRS) Distant Quasar Survey (DQS), that has produced rest-frame optical spectra of about 200 high-redshift quasars (z = 1.5–3.5). The GNIRS-DQS will produce new and improved ultraviolet-based black hole mass and accretion rate prescriptions, as well as new redshift prescriptions for velocity zero points of high-z quasars, necessary to measure feedback.
The first AI simulation of a black hole
Authors: Nemmen Rodrigo , Duarte Roberta , Navarro João P.
Published: March 2021

We report the results from our ongoing pilot investigation of the use of deep learning techniques for forecasting the state of turbulent flows onto black holes. Deep neural networks seem to learn well black hole accretion physics and evolve the accretion flow orders of magnitude faster than traditional numerical solvers, while maintaining a reasonable accuracy for a long time.
Recovering the origin of the lenticular galaxy NGC3115 using multi-band photometry
Authors: Buzzo Maria Luísa , Cortesi Arianna , Werle Ariel , de Oliveira Claudia Mendes
Published: March 2021

We perform simultaneous multi-band fitting, using the routine GALFITM, of the galaxy NGC3115, in order to recover the stellar populations of its main components (a bulge, a thin disc and a thick disc). We model 11 bands, from ultraviolet to infrared, in order to take into account the galaxy younger stellar population and the presence of the Active Galactic Nuclei (AGN). We find that the majority of the galaxy baryonic mass belongs to the thick disc, which is also the oldest galaxy component, consistent with results from the literature. Differently from previous works, we find that the bulge has the bluest colour and it is younger than the thick disc, either as a result of recent star formation activity, or AGN feedback, or white dwarf emission in an old stellar population. Finally, we propose that NGC3115 was formed either through a two-phase formation scenario, or via an outside-in quenching of an isolated spiral galaxy, whose thick disc had been heated-up via minor mergers with dwarf satellites.
The recurrent nuclear activity of Fornax A and its interaction with the cold gas
Authors: Maccagni F. M. , Serra P. , Murgia M. , Govoni F. , Morokuma-Matsui K. , Kleiner D.
Published: March 2021

Sensitive (noise ∼16 μJy beam−1), high-resolution (∼10″) MeerKAT observations of show that its giant lobes have a double-shell morphology, where dense filaments are embedded in a diffuse and extended cocoon, while the central radio jets are confined within the host galaxy. The spectral radio properties of the lobes and jets of reveal that its nuclear activity is rapidly flickering. Multiple episodes of nuclear activity must have formed the radio lobes, for which the last stopped 12 Myr ago. More recently (∼3 Myr ago), a less powerful and short (≲1 Myr) phase of nuclear activity generated the central jets. The distribution and kinematics of the neutral and molecular gas in the centre give insights on the interaction between the recurrent nuclear activity and the surrounding interstellar medium.
Feedback from ionised gas outflows in the central kpc of nearby active galaxies
Authors: David Edwin , Storchi-Bergmann Thaisa
Published: March 2021

We use integral-field spectroscopy obtained with the Gemini instrument GMOS-IFU (Gemini Multi-Object Spectrograph Integral Field Unit) to map the gas distribution, excitation and kinematics in the central kpc of 11 nearby active galaxies. We use channel maps to quantify the ionised gas masses, mass outflow rates and powers of the outflows in order to gauge the feedback effect of these outflows on the host galaxies. We compare this method with others previously used to calculate the feedback power of such outflows.
Distant quasar host galaxies and their environments with multi-wavelength 3D spectroscopy
Authors: Vayner Andrey
Published: March 2021

We have conducted a multi-wavelength survey of distant (1.3 < z < 2.6) luminous quasars host galaxies using the Keck integral field spectrograph (IFS) OSIRIS and laser guide star adaptive optics (LGS-AO) system, ALMA, HST and VLA. Studying distant quasar host galaxies is essential for understanding the role of active galactic nuclei (AGN) feedback on the interstellar medium (ISM), and its capability of regulating the growth of massive galaxies and their supermassive black holes (SMBH). The combination of LGS-AO and OSIRIS affords the necessary spatial resolution and contrast to disentangle the bright quasar emission from that of its faint host galaxy. We resolve the nebular emission lines, [OIII], [NII],, and [SII] at a sub-kiloparsec resolution to study the distribution, kinematics, and dynamics of the warm-ionized ISM in each quasar host galaxy. The goal of the survey was to search for ionized outflows and relate their spatial extent and energetics to the star-forming properties of the host galaxy. Combining ALMA and OSIRIS, we directly test whether outflows detected with OSIRIS are affecting the molecular ISM. We find that several mechanisms are responsible for driving the outflows within our systems, including radiation pressure in low and high column density environments as well as adiabatic and isothermal shocks driven by the quasar. From line ratio diagnostics, we obtain resolved measurements of the photoionization mechanisms and the gas-phase metallicity. We find that the quasars are responsible for photoionizing the majority of the ISM with metalicities lower than that of gas photoionized by AGN in the low redshift systems. We are now obtaining detailed observations of the circumgalactic medium (CGM) of these systems with the Keck Cosmic Web Imager (KCWI). The gas in the CGM may play an essential role in the evolution of these galaxies.
Outflows & Feedback from Extremely Red Quasars
Authors: Hamann Fred , Perrotta Serena , Zakamska Nadia
Published: March 2021

Feedback from accreting supermassive black holes is often invoked in galaxy evolution models to inhibit star formation, truncate galaxy growth, and establish the observed black-hole/bulge mass correlation. We are studying outflows and feedback in a unique sample of extremely red quasars (ERQs) during the peak epoch of galaxy formation (at redshifts 2.3 < z < 3.4). We identified ERQs in the Sloan Digital Sky Survey III (SDSS-III) Baryon Oscillation Spectroscopic Survey (BOSS) quasar catalog based on their extremely red i–W3 colors, but we find that ERQs typically have a suite of other extreme properties including 1) a high incidence of blueshifted broad absorption lines, 2) broad emission lines with unusually large rest equivalent widths (REWs), peculiar “wingless” profiles, and frequent large blueshifts (reaching ˜8740 km s-1), and 3) characteristically very broad and blueshifted [OIII] 4959,5007Å lines that trace ionized outflows at speeds up to ˜6700 km s-1. We propose that these ERQs represent a young quasar population with powerful outflows on the precipice of causing important disruptive feedback effects in their host galaxies.
Hybrids: where are we?
Authors: Ménard Claude
Published: March 2021

We owe Williamson for the formal introduction of hybrid organizations as essential building blocks in ‘the institutional structure of production’. The analysis of these institutional arrangements, which culminated inThe Mechanisms of Governance, provided a unified approach to the variety of setting within which transactions are embedded, opening a new perspective on a cornerstone of modern economies. This essay explores the past, present, and future of this breakthrough. First, it reviews the progressive integration of hybrids as a category of their own in the classic ‘make-or-buy’ model, inserting hybrids as an ‘intermediate’ form different from markets in that adaptation cannot be done unilaterally and different from ‘unified organizations’ in that adaptation cannot be done by fiat. Second, it shows how this initial characterization of hybrids, besides providing a coherent approach to empirical research available at the time, gave a powerful impulse to new contributions, identifying more rigorously the fundamental features of hybrids, throwing light on why firms go hybrid, and explicating the governance structure chosen. Last, it offers insights on a research program that remains a work in progress, delineating new terrains to explore and new puzzles to solve.
Experimental and numerical characterization of a grounded coplanar waveguide for nanoelectroporation applied to liposomes
Authors: Caramazza Laura , Paffi Alessandra , Liberti Micaela , Apollonio Francesca
Published: March 2021

Electroporation has become a powerful technological platform for the electromanipulation of cells and tissues for various medical and biotechnological applications. Recently, nanoporation based on nanosecond pulsed electric fields (nsPEFs) has gained great attention due to its potential to permeabilize the membrane of small vesicles. Here, the authors propose and characterize, both experimentally and through multiphysics modeling, a grounded coplanar waveguide compliant with the wideband requirements for nanosecond pulses to be used for experiments of drug delivery with liposomes activated by nsPEFs.
Wer braucht eine genetische Beratung?
Authors: Monnerat Christian , Dobbie Michaël
Published: March 2021

Zusammenfassung. Eine positive Familienanamnese für Mammakarzinom oder / und Ovarialkarzinom ist der Hauptrisikofaktor einer Frau, selbst an einem Mammakarzinom (oder / und Ovarialkarzinom) zu erkranken. Eine detaillierte Auswertung der Familienanamnese durch den Onkogenetiker erlaubt die Indikation für einen Gentest zu stellen. Die in der Schweiz verwendeten Kriterien zur Testung sind genau festgelegt. Hochrisiko-Frauen lassen sich durch den Nachweis einer pathogenen Mutation eines für Brust- und Eierstockkrebs prädisponierenden Gens wie BRCA1 oder BRCA2 identifizieren. Die Betreuung der Mutationsträgerinen muss gemäss internationalen Empfehlungen erfolgen.
Effect of vitamins on sexual function: A systematic review
Authors: Ghanbari-Homaie Solmaz , Ataei-Almanghadim Khatereh , Mirghafourvand Mojgan
Published: March 2021

Abstract: Sexual dysfunction can adversely affect the quality of life, self-confidence, and interpersonal relationships. Some studies reported a relationship between vitamin supplementation and sexual health. This systematic review aimed to evaluate the effect of vitamins on female and male sexual function. All relevant English and Persian articles published in English databases (Medline, Scopus, Cochrane Library, Web of Sciences, Psycho-Info, and Proquest) and Farsi databases (SID and Magiran) until July 2020 were searched. The Cochrane Handbook for Systematic Reviews of Interventions was used for assessing the risks of bias. A total of 11 randomized controlled trials (RCTs) on 337 women, 472 men, and 35 couples were included. One study reported that vitamin D 300000 IU supplement administrated twice through intramuscular injection (at the beginning and after four weeks) had a significant effect on female sexual function (p<0.05), whereas another study showed that vitamin D 2000 IU supplement for six months did not have any significant effect on female sexual function (p>0.05). A study reported the significant effect of niacin (vitamin B3) 1500 mg daily for 12 weeks on erectile function (p=0.004). The results showed that vitamins A, C, and E had no significant effect on male and female sexual function. The conduction of trials with long-term interventions is recommended to reach a more definitive conclusion about the effect of vitamins on sexual function.
Tibetan Plateau Precipitation Modulated by the Periodically Coupled Westerlies and Asian Monsoon
Authors: Cui Anning , Lu Houyuan , Liu Xingqi , Shen Caiming , Xu Deke , Xu Baiqing , Wu Naiqin
Published: March 2021

Knowledge of decadal‐centennial‐scale precipitation cycles is important for predicting the status of water resources and thus food security in the region influenced by the “Asian Water Tower” (the Tibetan Plateau, TP). However, the drivers of these precipitation cycles in the TP remain unclear. Here we present a 1,656‐years (5‐years‐resolution) mean annual precipitation record reconstructed by fossil pollen assemblages from the annually laminated sediments of a lake in the TP interior. The record reveals three dominant cycles, with lengths of ∼200‐, ∼88‐, and ∼60‐years, associated with changes in the Westerlies and the Asian monsoon. These precipitation cycles suggest that the current high precipitation in the TP interior results from the superposition of cyclic highs in precipitation, and this trend may continue for the next several decades.
Quantifying the Axial Magma Lens Dynamics at the Roof of Oceanic Magma Reservoirs (Dike/Gabbro Transition): Oman Drilling Project GT3 Site Survey
Authors: France Lydéric , Lombard Maéva , Nicollet Christian , Berthod Carole , Debret Baptiste , Koepke Juergen , Ildefonse Benoit , Toussaint Aurore
Published: March 2021

At oceanic spreading centers, the interactions between the igneous system that builds the crust, and the hydrothermal system that cools it govern the plumbing system architecture and its thermokinetic evolution. At fast‐spreading centers, most of those interactions occur around the axial magma lens (AML) that feeds the upper crust, and possibly part of the underlying mushy igneous reservoir. Heat extracted from crystallizing AML is transferred through a conductive boundary layer to the overlying hydrothermal system. Quantifying the AML physical and thermal evolutions and its interactions with hydrothermal system is therefore essential to understand oceanic accretion. Those general issues were the rationale of drilling ICDP OmanDP Hole GT3A, and we present herein the geological, structural, and petrological data that were used as a site survey to select its location. GT3 area enables observations in three dimensions of fossilized AMLs and overlying dikes. The new field data and corresponding mineral compositions are used together with thermokinetic and thermodynamic models to deliver an integrated dynamic model for the AML/hydrothermal system interactions. Results attest that the isotropic gabbro interval is composite, with gabbro bodies intruding and reheating both gabbros and dikes (up to 1,040°C). We show that AMLs should be considered as transient igneous bodies that likely crystallize from primitive MORBs in decades, releasing heat to the intruded hosts, and feeding high temperature vents on the seafloor. We show for the first time that the thermal gradient recorded in AML roof is consistent with the heat fluxes reported at active hydrothermal vents.
The Hydrogeomorphic History of Garu Crater: Implications and Constraints on the Timing of Large Late‐Stage Lakes in the Gale Crater Region
Authors: Putnam A. R. , Palucis M. C.
Published: March 2021

Paleolake deposits offer a valuable record for constraining ancient Martian environments and climate. Gale crater provides extensive evidence for a long and complex history of lakes; however, the exact timing, source of water, and climate under which these large lakes persisted are still unclear. We examined the geomorphology and mineralogy of Garu crater, an ∼30 km diameter crater ∼150 km to the east of Gale crater with an age of ∼3.5 Ga (Hesperian). Garu hosts a large NE‐prograding sedimentary deposit that emanates from an incised bedrock canyon. Based on detailed geomorphic analysis, we infer it to be a Gilbert‐type delta that records steadily rising water levels over 104–105 years. This aggradational stage is followed by a period of rapid desiccation, which is evidenced by a lack of post‐depositional incision into the delta. Coupled surficial and groundwater modeling and paleo‐flow analysis suggest that the highest mapped lake stand in Garu would have been coeval with one of the largest late‐stage lakes in Gale. Both lake stands would have been supported by groundwater and surface runoff, under a semiarid climate. Unlike Gale, there is no spectral evidence for salts in Garu, which suggests that lacustrine sedimentation in Garu occurred after the deposition of the sulfate layers within Gale's central sedimentary mound. The hydrogeomorphologic record of Garu crater suggests that the climatic conditions that allowed for late Hesperian lakes in Gale crater were not isolated, and other nearby craters and basins may have responded to similar forcings from a regionally integrated hydrologic system.
The 2018 Mw7.5 Highlands Earthquake in Papua New Guinea: Implications for Structural Style in an Active Fold and Thrust Belt
Authors: Mahoney Luke , Stanaway Richard , McLaren Sandra , Hill Kevin , Bergman Eric
Published: March 2021

The Papuan Fold and Thrust Belt (PFTB) in Papua New Guinea is actively forming within a complex tectonic setting at the boundary of the obliquely converging Australian and Pacific plates. The tectonic setting and inaccessibility of the PFTB make it one of the least well‐understood fold and thrust belts on Earth. On February 25, 2018, a Mw7.5 earthquake occurred within the PFTB, triggering an aftershock sequence which included five events ≥Mw6. In this study, we combine seismological, GPS and remote sensing observations to investigate the spatiotemporal distribution of crustal deformation during these events. All earthquakes ≥Mw6 were related to reverse offset on northeast‐dipping fault planes and five out of the six, including the mainshock, were associated with midcrustal focal depths (∼15–30 km). During the sequence, the PFTB underwent up to 1.2 m of uplift and ground deformation occurred over 7,500 km2. Combining these observations with our geological knowledge of this convergent margin highlights the primary control of the northern Australian passive margin on PFTB structural style. We propose that the earthquake sequence was related to tectonic inversion on a hidden extensional fault system beneath the PFTB and lateral variations along this fault zone had significant influence on the complex distribution of ground deformation. It follows that this fault system has had an important control on the evolution of variable structural styles within the PFTB. This study highlights the complexity that can characterize the evolution and structural style of fold and thrust belts.
Pyroptosis: mechanisms and diseases
Authors: Yu Pian , Zhang Xu , Liu Nian , Tang Ling , Peng Cong , Chen Xiang
Published: March 2021

Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.
LMNB2 promotes the progression of colorectal cancer by silencing p21 expression
Authors: Dong Chen-Hua , Jiang Tao , Yin Hang , Song Hu , Zhang Yi , Geng Hao , Shi Pei-Cong , Xu Yi-Xin , Gao Hong , Liu Lian-Yu , Zhou Lei , Zhang Zhao-Hui , Song Jun
Published: March 2021

Colorectal cancer is the second common cause of death worldwide. Lamin B2 (LMNB2) is involved in chromatin remodeling and the rupture and reorganization of nuclear membrane during mitosis, which is necessary for eukaryotic cell proliferation. However, the role of LMNB2 in colorectal cancer (CRC) is poorly understood. This study explored the biological functions of LMNB2 in the progression of colorectal cancer and explored the possible molecular mechanisms. We found that LMNB2 was significantly upregulated in primary colorectal cancer tissues and cell lines, compared with paired non-cancerous tissues and normal colorectal epithelium. The high expression of LMNB2 in colorectal cancer tissues is significantly related to the clinicopathological characteristics of the patients and the shorter overall and disease-free cumulative survival. Functional analysis, including CCK8 cell proliferation test, EdU proliferation test, colony formation analysis, nude mouse xenograft, cell cycle, and apoptosis analysis showed that LMNB2 significantly promotes cell proliferation by promoting cell cycle progression in vivo and in vitro. In addition, gene set enrichment analysis, luciferase report analysis, and CHIP analysis showed that LMNB2 promotes cell proliferation by regulating the p21 promoter, whereas LMNB2 has no effect on cell apoptosis. In summary, these findings not only indicate that LMNB2 promotes the proliferation of colorectal cancer by regulating p21-mediated cell cycle progression, but also suggest the potential value of LMNB2 as a clinical prognostic marker and molecular therapy target.
Activity of docetaxel, carboplatin, and doxorubicin in patient-derived triple-negative breast cancer xenografts
Authors: Martin Miguel , Ramos-Medina Rocio , Bernat Rebeca , García-Saenz Jose Angel , del Monte-Millan Maria , Alvarez Enrique , Cebollero Maria , Moreno Fernando , Gonzalez-Haba Eva , Bueno Oscar , Romero Paula , Massarrah Tatiana , Echavarria Isabel , Jerez Yolanda , Herrero Blanca , Gonzalez del Val Ricardo , Lobato Nerea , Rincon Patricia , Palomero Maria Isabel , Marquez-Rodas Ivan , Lizarraga Santiago , Asensio Fernando , Lopez-Tarruella Sara
Published: March 2021

Triple-negative breast cancer (TNBC) is highly responsive to neoadjuvant polychemotherapy regimens including anthracyclines, taxanes, and, more recently, carboplatin. However, there is inadequate information on the individual contribution of each of these agents to the global activity of the combinations, and the use of combinations of up to four of these drugs is associated with relevant toxicity. Identifying single-drug activity in the clinical neoadjuvant setting is challenging. We developed patient-derived xenografts (PDXs) from several chemotherapy-naïve TNBC samples to assess the antitumor activity of single drugs and combinations of drugs. PDXs were established from chemotherapy-naïve TNBC samples. Nine TNBC PDX models (all of which corresponded to a basal-like phenotype according to the PAM50 classifier) were treated with carboplatin, docetaxel, and doxorubicin and the combination of docetaxel and carboplatin. Only one of nine PDX models showed sensitivity to doxorubicin, while eight of nine PDX models showed sensitivity to docetaxel and carboplatin as single agents. The 3 PDX models derived from patients with gBRCA-1 or gPALB2 mutations were very sensitive to carboplatin single agent. All 6 PDX models from patients without hereditary germ-line mutations showed increased sensitivity to the combination of docetaxel and carboplatin. In the present study, docetaxel and carboplatin single agents were active drugs against basal-like TNBC, while doxorubicin monotherapy showed low activity. The combination of docetaxel and carboplatin was more effective than the drugs used as single agents, except in the PDX from patients with gBRCA1/PALB2 mutations.
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
Authors: Daamen Andrea R. , Bachali Prathyusha , Owen Katherine A. , Kingsmore Kathryn M. , Hubbard Erika L. , Labonte Adam C. , Robl Robert , Shrotri Sneha , Grammer Amrie C. , Lipsky Peter E.
Published: March 2021

SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated, hampering a precise approach to therapy. To address this, we carried out a comprehensive analysis of gene expression data from the blood, lung, and airway of COVID-19 patients. Our results indicate that COVID-19 pathogenesis is driven by populations of myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment. The relative absence of cytotoxic cells in the lung suggests a model in which delayed clearance of the virus may permit exaggerated myeloid cell activation that contributes to disease pathogenesis by the production of inflammatory mediators. The gene expression profiles also identify potential therapeutic targets that could be modified with available drugs. The data suggest that transcriptomic profiling can provide an understanding of the pathogenesis of COVID-19 in individual patients.
Insight into the direct interaction of Na+ with NhaA and mechanistic implications
Authors: Quick Matthias , Dwivedi Manish , Padan Etana
Published: March 2021

Na+/H+ antiporters comprise a family of membrane proteins evolutionarily conserved in all kingdoms of life that are essential in cellular ion homeostasis. While several human homologues have long been drug targets, NhaA of Escherichia coli has become the paradigm for this class of secondary active transporters as NhaA crystals provided insight in the structure of this molecular machine. However, structural data revealing the composition of the binding site for Na+ (or its surrogate Li+) is missing, representing a bottleneck in our understanding of the correlation between the structure and function of NhaA. Here, by adapting the scintillation proximity assay (SPA) for direct determination of Na+ binding to NhaA, we revealed that (i) NhaA is well adapted as the main antiporter for Na+ homeostasis in Escherichia coli and possibly in other bacteria as the cytoplasmic Na+ concentration is similar to the Na+ binding affinity of NhaA, (ii) experimental conditions affect NhaA-mediated cation binding, (iii) in addition to Na+ and Li+, the halide Tl+ interacts with NhaA, (iv) whereas acidic pH inhibits maximum binding of Na+ to NhaA, partial Na+ binding by NhaA is independent of the pH, an important novel insight into the effect of pH on NhaA cation binding.
Screening of osteoarthritis diagnostic markers based on immune-related genes and immune infiltration
Authors: Yuan Wen-Hua , Xie Qi-Qi , Wang Ke-Ping , Shen Wei , Feng Xiao-Fei , Liu Zheng , Shi Jin-Tao , Zhang Xiao-Bo , Zhang Kai , Deng Ya-Jun , Zhou Hai-Yu
Published: March 2021

Osteoarthritis (OA) is a chronic degenerative disease of the bone and joints. Immune-related genes and immune cell infiltration are important in OA development. We analyzed immune-related genes and immune infiltrates to identify OA diagnostic markers. The datasets GSE51588, GSE55235, GSE55457, GSE82107, and GSE114007 were downloaded from the Gene Expression Omnibus database. First, R software was used to identify differentially expressed genes (DEGs) and differentially expressed immune-related genes (DEIRGs), and functional correlation analysis was conducted. Second, CIBERSORT was used to evaluate infiltration of immune cells in OA tissue. Finally, the least absolute shrinkage and selection operator logistic regression algorithm and support vector machine-recurrent feature elimination algorithm were used to screen and verify diagnostic markers of OA. A total of 711 DEGs and 270 DEIRGs were identified in this study. Functional enrichment analysis showed that the DEGs and DEIRGs are closely related to cellular calcium ion homeostasis, ion channel complexes, chemokine signaling pathways, and JAK-STAT signaling pathways. Differential analysis of immune cell infiltration showed that M1 macrophage infiltration was increased but that mast cell and neutrophil infiltration were decreased in OA samples. The machine learning algorithm cross-identified 15 biomarkers (BTC, PSMD8, TLR3, IL7, APOD, CIITA, IFIH1, CDC42, FGF9, TNFAIP3, CX3CR1, ERAP2, SEMA3D, MPO, and plasma cells). According to pass validation, all 15 biomarkers had high diagnostic efficacy (AUC > 0.7), and the diagnostic efficiency was higher when the 15 biomarkers were fitted into one variable (AUC = 0.758). We developed 15 biomarkers for OA diagnosis. The findings provide a new understanding of the molecular mechanism of OA from the perspective of immunology.