bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between maternal psychological status and fetal hemodynamic circulation in late pregnancy
Authors: Jing Fu , Ruifen Yang , Xiaodong Ma , Huimin Xia
Published: January 2024

Background

The prevalence reported of maternal depression from the first to the third trimester was 7.4%, 12.8%, 12.0% respectively, which implies that around one-tenth of pregnant women suffer from psychological disorder during the whole pregnancy. It is assumed that during pregnancy the maternal-fetal circulation unit is also affected by maternal psychological status. The aim of this study is to explore the association between maternal psychological status and fetal dynamic blood flow circulation during pregnancy.

Methods

We recruited 102 singleton low risk pregnant women between 30 to 33 gestational weeks. The Symptom Checklist-90 (SCL-90) was used to assess maternal psychological status. Ultrasound Doppler was used to measure blood flow changes in maternal-fetal circulation. Pulsatility index (PI) value was measured in umbilical artery (UA), fetal middle cerebral artery (MCA) and maternal uterine arteries (UTA). Peak systolic velocity (PSV) was measured in MCA and velocity was measured in umbilical vein (UV). Statistical analysis was performed with standard nonparametric Mann-Whitney U tests. Two-tailed P values <0.05 were considered statistical significance.

Results

Of the 102 pregnant women, 12 patients show high levels of poor mental health. Women with poor mental health have higher umbilical artery PI values than good mental health patients (P=0.020). A higher MCA PI value is found in poor mental health patients but this does not reach statistical significance (P=0.053). Women with hostility show lower placental scores (P=0.030). Women with somatization demonstrate higher values in UA PI, MCA PI and MCA PSV (P=0.049, 0.030 and 0.035 respectively). A higher MCA PSV value is also found in phobic anxiety patients (P=0.046).

Conclusions

Poor mental health during pregnancy is found to have an adverse effect on maternal-fetal circulation. Umbilical artery and fetal cerebral circulation are more sensitive and affected by maternal psychological disorder.
Identification of Klebsiella pneumoniae strains harboring inactive extended-spectrum beta-lactamase antibiotic-resistance genes
Authors: Li Xu , Yao Zhai , Yuan Lyu , Qi Wang , Shuchang An , Jichao Chen , Yusheng Chen , Lin Liu , Jiabin Li , Zhancheng Gao
Published: January 2024

Background

The extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae has increasingly become a major contributor to nosocomial infections and can exhibit multiple antibiotic resistance. Previous studies have focused on the resistance genes in ESBL-producing strains, and the resistance-associated genetic environment of non-ESBLproducing strains has been ignored until now. Here, we investigated the occurrence and characteristics of non-ESBLproducing K. pneumoniae, which potentially carries unexpressed resistance genes.

Methods

K. pneumoniae strains were collected from five medical institutions in China from February 2010 to August 2013. The VITEK-2 ESBL detection system was used as a primary screen to identify the ESBL-producing phenotype, and the three primary types of ESBL-associated genes (CTX, SHV, and TEM) were detected by polymerase chain reaction (PCR) to confirm the strains presenting with a non-ESBL-producing phenotype. mRNA expression in the non-ESBLproducing strains was further screened by reverse-transcription PCR (RT-PCR) to validate their transcriptional efficiency.

Results

Out of 224 clinically isolated antibiotic-sensitive K. pneumoniae strains with a non-ESBL-producing phenotype, 5 (2.2%) were identified to carry inactivated ESBL blaSHV genes with intact upstream promoter regions and resistance gene sequences. Interestingly, three of the five antibiotic-sensitive K. pneumoniae strains containing ESBL blaSHV genes still exhibited mRNA transcription of blaSHV, while the other two exhibited no mRNA transcription.

Conclusion

These findings suggest that inactivated ESBL genes exist in non-ESBL-producing antibiotic-sensitive K. pneumoniae strains, which have the potential to transform the strain into an ESBL phenotype if an inappropriate application or overdose of antibiotics is implemented during clinical management.
Tartrate-resistant acid phosphatase 5b is a potential biomarker for rheumatoid arthritis: a pilot study in Han Chinese
Authors: Tao Cheng , Mingjun Wang , Zhiwei Chen , Eisenberg Robert A , Yu Zhang , Yaohong Zou , Yingsu Deng , Mian Wang , Ling Zhou
Published: January 2024

Background

Bone damage around the joints is one of the major pathophysiological mechanisms that leads to rheumatoid arthritis (RA) chronic disability. Serum tartrate-resistant acid phosphatase 5b (TRACP-5b) is secreted by osteoclasts, its activity can be used as a clinically relevant bone resorption marker. The aim of this study was to test whether the measurement of serum levels of TRACP-5b in patients with RA would correlate with measures of disease activity and with responses to therapy.

Methods

Fifty-six patients were randomly assigned to receive recombinant human cytotoxic tlymphocyte-associated antigen-4 immunoglobulin (RhCTLA4-Ig), infliximab or methotrexate (MTX). The clinical and serologic indicators of RA activity were evaluated at baseline and at 24 weeks. Serum TRACP-5b was measured by Enzyme-linked Immunosorbent Assay (ELISA) at 0, 12 and 24 weeks. Hand X-rays were obtained at baseline.

Results

At baseline, the levels of TRACP-5b correlated with the severity of X-ray damage, disease duration (r=0.332, P=0.012), and tender joint count (r=0.408, P=0.002). The 24 weeks values of TRACP-5b for RhCTLA4-Ig group and infliximab group differed significantly from the baseline values in each group (P <0.05; P <0.05), whereas only the value for RhCTLA4-Ig group differed significantly from the 24 weeks value for the MTX group (P <0.01). Considering the two biologics-treated groups together, the TRACP-5b levels at 24 weeks differed significantly from the baseline values only in those patients who reached an ACR70 level (P <0.05).

Conclusions

Measurement of serum TRACP-5b in RA patients reflects clinical and radiological measures of disease activity, treatment with certain biologics, and degree of response to therapy. TRACP-5b should be investigated further as a potential biomarker to predict response to therapy, including slowing of radiographic progression.
A vascular endothelial growth factor activating transcription factor increases the endothelial progenitor cells population and induces therapeutic angiogenesis in a type 1 diabetic mouse with hindlimb ischemia
Authors: Yongpeng Diao , Lishan Lian , Lilong Guo , Houzao Chen , Yuexin Chen , Xiaojun Song , Yongjun Li
Published: January 2024

Background

Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue perfusion. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. However, it has side effects that limit its therapeutic utility in vivo, especially at high concentrations. This study aimed to investigate whether an intramuscular injection of a genetically engineered zinc finger VEGF-activating transcription factor modulates the endothelial progenitor cells (EPC) and promotes therapeutic angiogenesis in a hindlimb ischemia model with type 1 diabetes.

Methods

Alloxan (intravenous injection) was used to induce type I diabetes in C57BL/6 mice (n=58). The ischemic limb received ZFP-VEGF (125 μg ZFP-VEGF plasmid in 1% poloxamer) or placebo (1% poloxamer) intramuscularly. Mice were sacrificed 3, 5, 10, or 20 days post-injection. Limb blood flow was monitored using laser Doppler perfusion imaging. VEGF mRNA and protein expression were examined using real-time PCR and ELISA, respectively. Capillary density, proliferation, and apoptosis were examined using immunohistochemistry techniques. Flow cytometry was used to detect the EPC population in bone marrow. Two-tailed Student's paired t test and repeated-measures analysis of variance were used for statistical analysis.

Results

ZFP-VEGF increased VEGF mRNA and protein expression at 3 and 10 days post-injection, and increased EPC in bone marrow at day 5 and 20 post-injection compared with controls (P<0.05). ZFP-VEGF treatment resulted in better perfusion recovery, a higher capillary density and proliferation, and less apoptosis compared with controls (P<0.05).

Conclusions

Intramuscular ZFP-VEGF injection promotes therapeutic angiogenesis in an ischemic hindlimb model with type 1 diabetes. This might be due to the effects of VEGF on cell survival and EPC recruitment.
Reduced dose of Bacillus Calmette-Guérin versus full dose of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer after transurethral resection bladder tumor: a meta-analysis of randomized controlled trials
Authors: Qin Xin , Wu Keming , Xie Libo , Zhao Sixiu , Lu Yiping
Published: January 2024

Background

Bladder cancer is widely known as the most common malignant tumor in the urinary tract, with 75%-85% of patients suffering from nonmuscle invasive bladder cancer (NMIBC). However, the optimal dose of Bacillus Calmette-Guérin (BCG) remains controversial. The aim of this study was to compare the therapeutic efficacy of full dose (FD) with the reduced dose (RD) of BCG.

Methods

Randomized controlled trials (RCTs) were selected through the Cochrane Library, PubMed and Embase and were supplemented by hand searching of bibliographies. The end points include overall survival rate, recurrence rate, progression rate and side effects.

Results

Five RCTs that included a total of 1 473 patients (727 in the reduced dose group vs 746 in the full dose group), with a median follow-up period from 33.5 month to 7.1 year. Disease in 80 of 687 (11.6%) patients assigned to the RD group progress to the muscular layer or distant metastasis, compared with 81 of 698 (11.6%) patients assigned to the FD group (RR=1.02; 95% CI, 0.77–1.36; P=0.89). The incidence of recurrence at three year was reported in all five studies to be 41.1% (299 of 727) and 36.1% (269 of 746) in the RD and FD groups, respectively (RR=1.13; 95% CI, 1.00–1.29; P=0.05). The 5-year survival rate was 75.9% (502 of 662) in the RD group, and 75.8% (510 of 673) in the FD group. In the RD group 41 of 655 (6.3%) patients and 56 of 663 (8.7%) patients in the FD group did not complete the treatment due to systemic or local side effects (RR=0.75; 95% CI, 0.51–1.10; P=0.14)

Conclusions

In general, the results of our study demonstrate a trend towards a reduction of the toxicity in reduced dose group without affecting the efficacy of treatment when compared with full dose. More trials with large sample size are still necessary to explore the prognosis of the patients with high risk of tumor in different dose group.
Detection of hepatic and pancreatic fat infiltration in type II diabetes mellitus patients with IDEAL-Quant using 3.0T MR: comparison with single-voxel proton spectroscopy
Authors: Jing Ma , Zhiqiang Song , Fuhua Yan
Published: January 2024

Background

Type II diabetes mellitus usually related to visceral and other organ (ectopic) fat. The purpose of this study was to detect hepatic and pancreatic fat infiltration in type II diabetes mellitus patients using 3.0T magnetic resonance (MR) and to compare the performance of iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-Quant) with single-voxel proton spectroscopy (H1-MRS).

Methods

The study protocol was approved by our Institutional Review Board. Written informed consent was obtained from each subject in this study. We prospectively performed IDEAL-Quant and single-voxel proton spectroscopy with an echo time of 35 ms on 24 type II diabetes patients and 10 healthy volunteers. The hepatic proton density fat fraction (HPDFF) and pancreatic proton density fat fraction (PPDFF) were calculated, compared, and analyzed by t-tests and Spearman's correlation.

Results

The HPDFF and PPDFF measured with IDEAL-Quant were significantly different between the healthy volunteers and type II diabetes patients (th
=9.377, P=0.000; tp
=2.813, P=0.008). The HPDFF and PPDFF measured with MRS were also significantly different between the healthy volunteers and type II diabetes patients (th=5.342, P=0.000; tp
=2.63, P=0.013). The HPDFF and PPDFF measured by the two methods were in good agreement (rh=0.854, P=0.000; rp
=0.774, P=0.000). The HPDFF and PPDFF were not significantly correlated with each other (r
MRS=0.203, p=0.248; r
IDEAL-Quant=0.301, P=0.084). The PPDFF measured with IDEAL-Quant was associated with body mass index (r=0.377, P=0.028).

Conclusion

IDEAL-Quant is a nice method for hepatic and pancreatic fat detection, and it can be applied in clinical practice.
Detection of periodontal pathogens in the patients with aortic aneurysm
Authors: Ding Fang , Lyu Yalin , Han Xiao , Zhang Hai , Liu Dongyu , Hei Wei , Liu Yinhua
Published: January 2024

Background

The occurrence and development of aortic aneurysm (AA) are associated with infection. Some researchers have detected the DNA of periodontal pathogens in AA samples in certain populations. However, it has not been done in Chinese population. The objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of AA patients.

Methods

Eighty-nine subjects with AA and 59 subjects without AA were examined. Periodontal clinical parameters were evaluated. Unstimulated saliva and subgingival plaque samples were collected from all subjects. Twenty-six dissected AA samples were obtained. Evidence of eight periodontal pathogens including Porphyromonas gingivalis (Pg), Actinobacillus actinomycetemcomitans (Aa), Prevotella intermedia (Pi), Tannerella forsythensis (Tf), Treponema denticola (Td), Campylobacter rectus (Cr), Fusobacterium nucleatum (Fn), and Prevotella nigrescens (Pn) was ascertained in all samples by 16S rRNA-based polymerase chain reaction (PCR) assay.

Results

The periodontal indexes including plaque index (PLI), probing depth (PD), bleeding index (BI), and clinical attachment loss (CAL), of the six Ramfjord index teeth were significantly higher in the AA group than those in the control group (P <0.01). Eight periodontal pathogens in subgingival plaque samples were more frequently detected in the AA group than in control group. The difference in prevalence between the groups was significant for six (out of eight) periodontal pathogens assayed (Pg, Pi, Fn, Pn, Tf, and Td, P <0.01). Additionally, all eight periodontal pathogens were more frequently detected in saliva samples of the AA group than in those of the control group, again with six (out of eight) (Pg, Pi, Fn, Cr, Tf, and Td) displaying significant differences in prevalence between the two groups (P <0.01). Out of 26 aneurysm samples examined, Pg, Pi, Fn, Cr and Tf were detected in 6 (23.1%), 2 (7.7%), 3 (11.5%), 1 (3.8%), 2 (7.7%), respectively, and Aa, Pn, and Td were not detected in dissected aneurysm samples.

Conclusion

Results of this study suggested that periodontal infection is associated with the occurrence of AA.
Iodine deficiency up-regulates monocarboxylate transporter 8 expression of mouse thyroid gland
Authors: Hu Zhimei , Zhuo Xiaohua , Shi Yanan , Liu Xin , Yuan Jihong , Li Lanying , Sun Yina
Published: January 2024

Background

Iodine deficiency is a major factor affecting thyroid auto-regulation, the quantity of iodine may greatly influence the synthesis of thyroid hormones (THs). It has long been believed that TH enters the cell through passive diffusion. Recent studies have suggested that several transporters could facilitate transportation of TH. The monocarboxylate transporter 8 (MCT8) was identified as a very active and specific TH transporter. The purpose of this study was to investigate whether iodine insufficient affected the expression of MCT8 in the thyroid gland.

Methods

Sixty BALB/c mice were randomly divided into two groups: control group was fed with standard feed (iodine concentration of 300 μg/kg); while low-iodine (LI) group received iodine-insufficient feed (iodine concentration of 20-40 μg/kg). After 3 months, 10 mice of each group were sacrificed. The remaining 20 mice of each group were kept till 6 months. From the LI group, we randomly selected 15 mice and injected triiodothyronine (T3, 100 μg/kg body weight per day) intraperitoneally for 24, 48 or 72 hours (5 mice for each time-point). Then, all the mice were sacrificed. Mouse serum thyroxine (T4), T3, and thyroid-stimulating hormone (TSH) levels were determined by chemiluminescence immunoassay (CIA). The protein content or messenger RNA (mRNA) level of thyroid MCT8 was measured by Western blotting analysis or real time RT-PCR respectively. MCT8 subcellular location in thyroid tissues was probed with immunohistochemistry (IHC) assay.

Results

We found that mouse serum T3 and T4 levels decreased and TSH level increased by the end of the third month. Consistent with these findings, there was significant goiter and hypothyroidism in the LI group. Meanwhile, the MCT8 mRNA increased to 1.36-fold of the level in the control group at the 3rd month. At 6th month, the serum T4 level in LI mice remained at a lower level, and MCT8 mRNA expression continued rising to nearly 1.60-fold compared with the control group. The protein content was also about 3 times higher than that in the control group. IHC results also revealed MCT8 was of higher expression and localized in the cytoplasm of thyroid follicular cells. After providing exogenous T3 to iodine deficient mice, the serum T3 and T4 gradually increased, whereas MCT8 mRNA and protein both started to decrease and returned to the same level as the control group.

Conclusion

There is a compensatory increase in thyroid MCT8 expression to enhance its capability to transport TH from thyroid to the blood circulation in iodine deficient mice.
Investigation of drugs responsible for perioperative anaphylactic reactions using cellular allergen stimulation test
Authors: Xin Xin , Zou Yi , Xing Lijiao , Yin Jia , Gu Jianqing , Wang Zixi , Huang Yuguang , Zhao Jing
Published: January 2024

Background

Anaphylactic reactions during anesthesia and operation are common and life threatening. Follow-up investigation is necessary for avoiding potential re-exposure of the patients to the offending drugs. The purpose of this study was to assess cellular allergen stimulation test (CAST) as a diagnostic instrument in immunoglobulin E (IgE)- and non-IgE-mediated anaphylactic reactions.

Methods

This study included 25 patients who developed perioperative anaphylactic reactions and 10 subjects that tolerated anesthetics and other drugs during perioperative period from September 2009 to October 2013 in Peking Union Medical College Hospital. We performed skin tests and flow cytometric analysis of basophil activation-based CAST in all subjects.

Results

Of the 25 patients, 17 had IgE-mediated anaphylactic reactions (causative agent identified by skin tests) and 8 had non-IgE-mediated anaphylactic reactions (negative skin tests). CAST showed a sensitivity of 42.9%, specificity of 90%, and negative predictive value of 80.6% for neuromuscular blocking agents.

Conclusions

CAST may be useful for the diagnosis of anaphylactic reactions during perioperative period. Our findings call for further investigation to increase the sensitivity of the test.
Rejection of insulin therapy among patients with type 2 diabetes in China: reasons and recommendations
Authors: Zhenzhen Xiong , Li Yuan , Xiaohui Guo , Qingqing Lou , Fang Zhao , Li Shen , Mingxia Zhang , Zilin Sun
Published: January 2024

Background

Insulin injection therapy is one of the most effective treatments for type 2 diabetes mellitus (T2DM). Many people with T2DM in western countries resist starting insulin therapy; whether the same is true in China is unknown. This survey-based study assessed acceptance and rejection of insulin therapy among individuals with T2DM in China and self-reported reasons for these therapy choices. It also examined what methods may be useful for increasing the rate of insulin acceptance.

Methods

A multi-center, cross-sectional survey was conducted between April and July 2010 to a convenience sample of inpatients and outpatients at 50 medical centers across 29 administrative divisions in China. Data were collected on sociodemographic and T2DM characteristics, therapy regime, and attitudes toward insulin therapy.

Results

A total of 6 043 patients were surveyed, and 5 961 complete questionnaires (98.6%) were used in the analysis. Just over half the respondents (3 460, 58.0%) reported negative attitudes to insulin therapy, including 2 508 of the 4 469 patients (56.1%) whose physicians had recommended it to them. Of the patients counseled to use insulin, 800 (17.9%) were unwilling to start therapy and cited the following reasons: inconvenience (64.3%); concerns over addiction (24.6%); pain (14.3%); side effects (14.1%); and high cost (13.6%). Logistic regression suggested that respondents would be more willing to undertake insulin therapy if they had received diabetes education, had positive attitudes to the treatment, had higher glycosylated hemoglobin level, or had suffered diabetes for a longer period or with more complications.

Conclusions

Patients with T2DM in China are often resistant to insulin therapy if they have been diagnosed with the disease for a relatively short time or if the disease has been relatively mild. Educating patients on the benefits of insulin therapy, not only at the initial diagnosis with T2DM but also when insulin therapy becomes necessary, will likely increase their willingness to undertake it.
Evaluation with low-dose dual-phase helical computed tomography of patients with thyroid lesions
Authors: Li Lin , Wang Yong , Zhao Yanfeng , Zou Shuangmei , Lin Meng , Yu Xiaoduo , Tang Wei , Zhou Chunwu , Luo Dehong
Published: January 2024

Background

The incidence of thyroid cancer has been increasing. Our aim was to evaluate the efficacy of low-dose dualphase helical computed tomography (CT) in the characterization of thyroid lesions, and to discuss the relationship between image characteristics and their pathology.

Methods

One hundred and six patients with thyroid lesions underwent low-dose dual-phase helical CT after the injection of contrast material. CT scans were obtained at arterial and venous phase with delays of 25 and 65 seconds, and tube current of 60 and 120 mA, respectively. The attenuation change in the lesion between the arterial and venous phase was analyzed and categorized as “increased,” “decreased,” “mixed” or “no change.”

Results

Histopathologic diagnosis was obtained by surgery in 106 patients (115 lesions). Of the 106 patients, 45 had nodular goiter, 5 thyroid adenoma, 6 thyroiditis, and 50 papillary thyroid carcinoma (PTC) (59 lesions). The attenuation value showed a significant difference (P<0.05) between the arterial and venous phase for the high attenuation area. There was statistical significant difference in terms of attenuation value in high attenuation areas at both phases and in low attenuation areas on arterial phase between nodular goiter and PTC (P<0.05). However, there was no significant difference in attenuation value between adenoma and PTC. Twenty-nine cases (76.3%) of goiter manifested mixed type, 3 cases (3/5) of adenoma showed decreased type, 6 cases (6/6) of thyroiditis showed increased type, and 55 cases (93.2%) of PTC showed decreased type attenuation. The sensitivity, specificity for thyroid carcinoma by dual-phase CT were 94.9% and 80.4% respectively. The overall diagnostic accuracy for thyroid lesions by dual-phase CT was 87.8%.

Conclusions

The performance of dual-phase helical CT is related to the pathological structure of the lesions. The analysis of enhancement patterns by using dual-phase helical CT will be helpful in the differential diagnosis of thyroid lesions.
Comparison between two types of “Scheuermann disease-like people”: thoracolumbar disc herniation patients and healthy volunteers with radiological signs of Scheuermann's disease
Authors: Guo Xinhu , Chen Zhongqiang , Liu Ning , Guo Zhaoqing , Qi Qiang , Li Weishi , Zeng Yan , Sun Chuiguo
Published: January 2024

Background

Scheuermann's disease (SD) is a spinal disorder and includes both a classic form and an atypical form. Interestingly, its existence among the general population as well as the disc disease patients is common. One of our previous studies showed that about 18% of the hospital staff members meet the SD criteria. On the other hand, another study has demonstrated that 95.2% of the symptomatic thoracolumbar disc herniation (STLDH) patients meet the SD criteria, which suggests that STLDH is very likely a special form of SD. The purpose of this study was to discriminate the factors contributing to the development of STLDH by comparing STLDH patients with the healthy SD-like hospital staff members.

Methods

This is a retrospective study including 33 STLDH patients who met the SD criteria and 30 SD-like hospital staff members. The STLDH group was chosen from a group of patients who underwent surgery after a diagnosis of STLDH (T10/11-L1/2) at our hospital between June 2007 and June 2010. SD-like hospital staff members were chosen from a database created in 2007, which contained a lumbar MR and low back pain (LBP) questionnaire of 188 hospital staff members. The demographic and radiologic characteristics were compared between groups.

Results

There was no statistical difference in sex, age, and height between the two groups. The STLDH patients had higher body weight, boby mass index, and thoracolumbar kyphotic angle than SD-like hospital staff members. In addition, STLDH patients had more levels of Schmorl's nodes (3.5±1.7 vs. 2.0±1.9, t=3.364, P=0.001) and irregular endplateson (4.0±1.9 vs. 2.7±1.9, t=2.667, P=0.010) compared to the SD-like hospital staff members.

Conclusions

Higher body weight, higher body mass index, larger thoracolumbar kyphosis, and more Schmorl's nodes and irregular endplates on MR may be associated with the development of STLDH in “SD-like people.”
Functional Theory of the Development of Religiosity and Knowledge on Intention to Purchase Bubble Tea Drinks in Indonesia
Authors: Anggara Astri Friday Nova , Masnita Yolanda
Published: January 2024

Society competes fiercely to produce the best goods and attract customers with various strategies and methods. Due to high demand, the same phenomenon also occurs in Indonesia, especially in the culinary sector. The food and beverage industry in Indonesia experienced an increase from 2020 to 2021 by 2.54 percent to IDR 775.1 trillion, the Central Statistics Agency (BPS) reported that the national food and beverage industry's gross domestic product (GDP) based on current prices (ADHB) was IDR 1.12 quadrillion in 2021. The type of research used in this research is a quantitative research approach. Data collection was carried out through a Google Form survey tool using the convenience sampling method and structural equation modeling (PLS) which was distributed to 121 respondents. The analysis carried out validity, reliability, Goodness-of-Fit and hypothesis testing. The research results show that there is a positive and significant relationship between the utilitarian function, knowledge and religiosity with Attitude Towards Advertising. Apart from that, this research shows that there is a positive and significant relationship between Attitude Towards Advertising and Retailer Brand on Customer Purchase Intentions. This research also shows that attitude towards advertising can mediate religiosity and knowledge on customer purchase intention.
LOKAKARYA TIM KOMUNIKASI UPH KEPADA ASN KABUPATEN MINAHASA SELATAN TENTANG CITY BRANDING - (SDG #11)
Authors: Scheffer-Sumampouw Carly Stiana , Ginting Magdalena Lestari , Aprilia Ilynka Maria
Published: January 2024

Menindaklanjuti nota kesepahaman antara UPH dan Kabupaten Minahasa Selatan, maka sebagai langkah pertama dari implementasi kerja-sama perguruan tinggi dengan pemerintah kabupaten, diadakanlah lokakarya yang merupakan rangkaian kegiatan dari Pusat Studi G20 Indonesia: UPH Giving Back to Community 2023: North Sulawesi.

Tahapan pelaksanaan kegiatan pengabdian kepada Masyarakat diawali dengan needs assessment di bulan April 2023. Dalam tahapan inilah, pihak mitra menyatakan kebutuhan prioritas pemerintah daerah ialah pengembangan pariwisata dan secara spesifik membutuhkan pengetahuan dan keterampilan dalam hal digitalisasi.

Untuk itu, lokakarya yang dilaksanakan fokus pada city branding dengan judul materi lokakarya: DIGITALISASI PARIWISATA dan KOMUNITAS, KOTA BERKELANJUTAN SDG #11). Kegiatan ini dihadiri oleh 35 aparatur sipil negara (ASN). Fasilitator utama dari prodi ilmu komunikasi dibantu oleh 5 fasilitator lainnya dan seorang multimedia/notulen menghasilkan transfer knowledge antara akademisi dan ASN yang menghasilkan konsep smart city branding 3P: people, place and product yang secara khas merupakan identitas daerah kabupaten Minahasa Selatan.
Espina Bífida; Generalidades y Procedimiento para su Intervención Quirúrgica, una Revisión Bibliográfica
Authors: Gálvez González Hugo Mario
Published: January 2024

Dentro de la gama de malformaciones durante el desarrollo fetal destaca la espina bífida la cual se refiere a una malformación que repercute en el desarrollo del tubo neural y demás estructuras en su periferia, este aparece durante el primer trimestre de embarazo, específicamente el primer mes de gestación. Está anomalía en el desarrollo del cierre del neuróporo tiene una incidencia de 4 a 5 casos en cada 10,000 neonatos y corresponde a una de las principales causas de discapacidad neurológica, motora y también cognitiva. Para la recopilación de los textos con los que se pudo contextualizar el siguiente estudio se utilizó un enfoque metodológico basado en la revisión bibliográfica de varias literaturas con respecto al tema: Espina Bífida, a nivel teórico.
Revisión Bibliográfica: La Neurocisticercosis
Authors: Alcivar Ruth , Engracia Doménica , Garcés Sayenka , Roman Carlos
Published: January 2024

In this bibliographic review an analysis is analyzed from a general approach on Neurocysticercosis, this infection generally caused by larval cysts presents a negative result on human health, its infection and spread process in the human body implies the development of problems health, generally causing cysticercosis. Using a descriptive methodology, a compilation of updated information is carried out from indexed journals and scientific articles in which the characteristics of this infection, infectious process, causes and effects on the human organism and treatments applied to mitigate the infection are detailed. In conclusion, this infection requires immediate medical attention, the diagnosis of neurocysticercosis requires high precision medical equipment to determine the progress of the infection in the body and avoid serious health problems in humans. Determining the symptoms in time and a medical check-up allows us to recognize the presence of these parasites and prompt intervention to eliminate the larvae through surgery.
Osmanlı Belgelerinin Tarihlerine Dâir
Authors: S. Kütükoğlu Mübahat
Published: January 2024

Osmanlı belgelerinin cinslerine göre tarihlerinin atılış şekilleri farklıdır. Bazılarında Arapça tarih kullanılmıştır. Bir kısmında ayın tarihleri tam olarak yazılırken bazılarında on günlük bölümlerin belirtilmesiyle yetinilmiştir. Bir kısım belgelerde ise ayın günü ile yıl rakam olarak, ay ise belli rumuzlarla gösterilmiştir.

Dikkat edilmesi gereken ise yılın tam olarak yazılmadığı tarihlerdir. Bir kısmında binler, bir kısmında binler ve yüzler, hatta nadir olmakla beraber, onlar haneleri de yazılmamıştır. Böyle belgelerde ekleri ve arkasındaki muâmele kayıtları dikkate alınmalı ve belge diplomatik açıdan olduğu kadar teşkilât ve müessese tarihleri de göz önüne alınarak değerlendirilmelidir.

Bu yazıda, Osmanlı belgelerindeki çeşitli tarih tipleri, örnekleriyle gösterilmiştir.
Pietro Del Massaio’nun Planına Göre 15. Yüzyılda Edirne’nin Kentsel Mekân Değerlendirmesi
Authors: Özkök Mete Korhan , Yenen Zekiye
Published: January 2024

Edirne kenti bir Osmanlı başkenti olmasına karşın; mekânsal gelişim sürecine dair yazılı ve görsel kaynaklar özellikle 19. yüzyıl öncesi için kısıtlıdır. Edirne kentine yönelik bilinen en eski haritaların 1854 yılı sonrasına ait olması tarihsel, mekânsal incelemelerde ve tarihsel verilere dayalı olması gereken fiziki müdahalelerde kısıt yaratan bir konudur. Yapılan incelemeler ve araştırmalar sonucunda Batlamyus’un Coğrafya isimli eserinin 15. yüzyılda Pietro del Massaio tarafından hazırlanmış Latin 4802 isimli kopyasında Edirne/ Kaleiçi Bölgesini gösteren plan tespit edilmiştir. 15-16. yüzyıllar arası haritacılık ve kopya eser üretiminde görülen değişimler nedeniyle, tespit edilen plan bulunduğu dönem açısından tek örnektir. Ancak içerik bakımından dönemin mekânsal yapısına dair temel okuma ve çözümlemeleri yapmak mümkün olmaktadır. Bu çalışmanın temel amacı; bu plana yönelik incelemelere dayanarak 15. yüzyıl Edirne kenti Kaleiçi Bölgesinin mekânsal kurgusuna yönelik çıkarımların yapılmasıdır. Bu kapsamda tarihsel okumalar, ek plan ve haritalar gibi kaynakların da desteği ile sur kapıları, yollar, donatılar olmak üzere kentsel çevreye yönelik üç ana başlıkta incelemeler ve tespitler yapılmıştır. Çalışmanın özgün katkısı, literatürde ilk kez ele alınan bu belge ile Edirne kenti için kentsel ölçekte mekânsal gelişim ve kent tarihi konularına yönelik yorumların geliştirilmesidir. Ayrıca Kaleiçi bölgesinin özellikle dini/kamusal donatılar açısından bir hizmet bölgesi niteliğine sahip olduğu da söz konusu belgeye dayanarak tespit edilebilmiştir.
Türklere Karşı Zafer Kehaneti Yahut Propaganda: Alman Hümanisti Sebastian Brant’ın Kayzer I. Maximilian’ı Savaşa Teşvik İçin Yazdıkları (1494-1501)
Authors: Ercan Hüseyin Onur
Published: January 2024

Almanya’nın en önemli hümanistleri arasında yer alan Sebastian Brant, Latince ve Almanca kaleme aldığı yazılarında, ayrıca resimli broşür/el ilanı olarak dağıtılan çok sayıda şiirinde I. Maximilian’ı Kutsal Roma Alman İmparatorluğu’nu düzene sokmaya, kilisede reform yapmaya ve Fransızlar ile Türklerin yayılmasına karşı savaşmaya teşvik etmiştir. Bu makale esas itibarıyla Alman hukukçu ve hümanisti Sebastian Brant’ın özellikle Habsburg İmparatoru I. Maximilian döneminde Türkler ve İslâm aleyhine yazdığı metinlerin, tarihî arka planı gözeterek, propaganda dili ve Osmanlılara karşı sefer düzenlenmesi açısından değerlendirmesinden oluşmaktadır. Brant’ın Türk temasını işlediği ve 1494-1513 yılları arasına tekabül eden yayınları içerisinden -hâkim rengi göstermesi bakımından yeterli ölçüde fikir verici- dördü üzerinde durulmuştur: Das Narrenschiff (1494), De origine (1495), Thurcorum terror et potentia (1498), Von der Vereinigung der Könige und Anschlag an die Türken (1501). Bu yayın aralığının aslında II. Bayezid dönemine, Osmanlıların Batı politikalarına daha çok ağırlık vermeyi tercih ettiğinin görüldüğü yıllara rastlamış olması, özellikle Mora seferlerinin getirdiği hava içinde yerini bulması dikkat çekicidir. Bir başka ifadeyle dönemin atmosferinin, I. Maximilian dönemindeki Haçlı seferi çalışmaları bağlamı içinde olan bu literatürün ortaya çıkmasında büyük önem taşıdığı söylenebilir.
Yeni Dönem Kazı Sonuçları Işığında MÖ 3. Binyıl Sonu-2. Binyıl Başında Kültepe-Kaniş
Authors: Kulakoğlu Fikri , Genç Elif , Öztürk Güzel , Rıdvanoğulları Yılmaz
Published: January 2024

Kayseri il merkezinin 20 km kuzeydoğusunda yer alan Kültepe-Kaniş, Erciyes Dağı’nın kuzeyinde uzanan ve Sarımsaklı Deresi tarafından sulanan bereketli ovada yükselmektedir. Kaniş höyüğü ve aşağı şehir olmak üzere iki bölümden oluşan yerleşim 2,5 km çapındadır. Bu ölçüleriyle Kültepe yalnız Anadolu’nun değil aynı zamanda tüm eski Yakın Doğu’nun en büyük Tunç Çağı kentlerinden birisidir. Bu makale, eski Yakın Doğu arkeolojisi için kilit yerleşim yerlerinden olan Kültepe-Kaniş’in MÖ 3. binyıl sonu-2. binyıl başına tarihlenen ve son dönemde kazılan yapı katlarına ait ilk sonuçları içermektedir. Son dönemde höyüğün güneybatısında yapılan kazılar, Kültepe’deki Erken Tunç Çağı III tabakalarına ait anıtsal binalarının yerini, MÖ 3. binyıl sonlarında ve 2. binyıl başlarında birbiri üstüne inşa edilmiş küçük konutlar ile bunlara ait işliklerin aldığını göstermektedir. Ancak, mimarinin aksine; literatürde “Alişar III boyalıları” olarak bilinen seramik örnekleri ile monokrom çanak-çömlek geleneği ve formları, Kültepe’de Orta Tunç Çağı’nda kültürel bir devamlılığın olduğunu gösterir. Kültepe-Kaniş’te gerçekleştirilen yeni dönem kazılarında elde edilen veriler, söz konusu süreçte yerleşimin kesintisiz devam ettiğine işaret etmekle kalmaz, aynı zamanda MÖ 3. binyılın sonunda Orta Anadolu ve çevresinde meydana gelen sosyo-ekonomik değişimin izlerini mimari kalıntılar üzerinden analiz etmek için de önemli kanıtlar sunar.
Güllük Körfezi’nde Bir Liman
Authors: Baldıran Asuman , Görgülü Umut
Published: January 2024

Iasos Antik Kenti, Muğla ili, Milas ilçesi, Kıyıkışlacık Mahallesi sınırlarında, Milas ilçesinin yaklaşık 26 km batısında yer almaktadır. Antik kentin deniz yolu ile Argos’dan gelen kolonistler tarafından kurulduğuna inanılmaktadır. Antik yerleşim eskiden Iasos Körfezi (Sinus Iasicus) olarak adlandırılan derin ve uzun bir koy içindeki kayalık yarımada üzerinde kurulmuştur; burası şimdi Mandalya veya Güllük Körfezi olarak bilinir. Doğuda, küçük ve verimli bir ovanın ardında Grion Dağı (günümüzde Milas’a giden modern yolun aştığı Paşalı Dağı) yükselir. Antik çağda, Mylasa ve Didyma-Miletos arasında gelişmiş kara yolu güzergâhı yoktu. Bu nedenle Iasos’un diğer kentlerle ilişkisi ve ticari faaliyetleri doğal olarak, deniz yolu ile sağlanmakta idi.

Iasos, büyük olanı doğuda dağlık bir burunla çevrili, küçük olanı ise batı yönde olmak üzere iki limana sahip bir şehirdir. Günümüzde doğu liman yapılarına ait herhangi bir iz görülmemektedir, ancak batı limanda mendirek izleri saptanabilmektedir.

Batı limanda saptanan izler Agora ile aynı yapı katındadırlar ve bunlar Erken İmparatorluk Dönemi’ne tarihlenmektedirler. Olasılıkla, Orta Bizans Dönemi’nde batıdaki küçük limana bir kule eklenmiştir. Kulenin kuzey ve batısı sağlam destek duvarlarıyla güçlendirilmiştir. Bu kulenin yapım tarihi hâlâ tartışmalıdır. Kıbrıs’taki kalelerle yapılan karşılaştırmalar sonucunda, kulenin yapımının Bizans İmparatorluğu’nun sıkıntılı döneminde denizden gelebilecek tehlikelere karşı güçlendirildiği 12.-13. yüzyıllar olmalıdır. Günümüzde Doğu ve Batı Limanlarda suyun altında bazı taş blokları görmek mümkündür.
İznik Çini Fırınları Kazısı’nda Bulunan Süzgeçli Testi Formları
Authors: Arlı V. Belgin Demirsar , Kaya Şennur , Arlı Hakan
Published: January 2024

Bursa ili, İznik ilçe merkezinde 1981 yılında başlayan ve 1984 yılından itibaren BHD (Belediye Hamamı Doğusu) kodlu kazı alanında sürdürülmekte olan İznik Çini Fırınları Kazısı’nda 2014-2019 çalışma mevsimlerinde kazısı yapılan A-B-C /9-10-11 plan karelerinde bulunan kırmızı hamurlu kalıba baskı ve baskı dekorlu tabak, kâse, testi ve süzgeçli testi formlarında kaplara ait parçalar, çeşitli çalışmalarda form, teknik ve bezeme özelliklerine göre ele alınarak değerlendirilmiştir. Bu çalışmalar kapsamında, İznik’te üretilen süzgeçli testilerin teknik ve bezeme özellikleri üzerinde de durularak, bunların gövde formları ve bezemeleri kalıba baskı tekniğiyle meydana getirilen türü dışında dış yüzeylerine basit baskı yivlerin uygulandığı örneklerinin bulunduğundan da bahsedilmiştir. Kalıba baskı tekniğinde üretilmiş süzgeçli testilere ait gövde parçaları ve bunların yapımında kullanılan pişmiş toprak kalıpların seçili yedi örneğine uygulanan pXRF ölçümlerinde de en geç 15. yüzyılın sonlarına tarihlenebilecek kimyasal bileşenlere rastlanılmıştır.

Önceki tespitler ışığında bu makalede, kalıba baskı gövdeli süzgeçli testi parçaları ile tamamı çarkta çekilerek gövdeleri baskı yivlerle bezenen süzgeçli testi parçalarının form özelliklerinin daha kapsamlı tanıtılması amaçlanmıştır. Bu amaç doğrultusunda tüme yakın ya da formu açısından önemli bulunan altı kazı buluntusu seçilerek bunlar diğer kazı buluntularıyla birlikte değerlendirilmiştir. Sonuç olarak, İznik’te kırmızı hamur kullanılarak iki farklı yöntemle üretilmiş olan süzgeçli testilerin aynı dönemde Anadolu’da görülen seramik üretim gelenekleri ile ilişkili ancak özgün örnekler oldukları saptanmıştır.
Improving Science Learning Outcomes through a 5M Based Scientific Approach for Class IV Students at Madrasah Ibtidaiyah Imam Syafi'i Gorontalo
Authors: Kulati Sri Jian , Isa Abd Hamid , Mooduto Yulanti S
Published: January 2024

This research aims to improve science lesrning outcomes trhough a scientific approach by applying the 5Ms, namely (Observe, Ask, Try, Reason and Communivate). The approach used show that 5m based learning has been implementated in science learning using a scientifi approach with the activities of observing, acking, trying, reasoning and comunacating.
Polimorfismo de proteína 5,10-metilentetrahidrofolato reductasa en población venezolana
Authors: Chacín Marycarmen , Bravo Martha , Arends Anabel
Published: January 2024

El folato es un miembro del grupo de la vitamina B y está relacionado con enfermedades crónicas como anemia megaloblástica, enfermedad cardiovascular, cáncer, disfunción cognitiva y riesgo de defectos del tubo neural. La proteína 5,10- metilentetrahidrofolato reductasa (MTHFR) juega un papel clave en el metabolismo del folato mediante la síntesis de nucleótidos y reacciones de metilación. El gen MTHFR se encuentra en el cromosoma 1 (1p36.3), y se han descrito dos alelos comunes, el alelo C677T (termolábil) y el alelo A1298C. El objetivo de este estudio es evaluar la distribución de los polimorfismos genéticos en MTHFR C677T y A1298C en la población venezolana. METODOS: estudio de tipo transversal, descriptivo, experimental y correlacional Las muestras de sangre se colectaron en 314 donantes no emparentados y sanos de la población. Los polimorfismos de un solo nucleótido (SNP) MTHFR 677C>T y 1298A>C se analizaron mediante polimorfismo de longitud de fragmento de restricción de reacción en cadena de polimerasa (PCR-RFLP). El desequilibrio de ligamiento (LD) entre pares de SNP se calculó mediante la prueba X. usando Prism 5 (GraphPad software, Inc). RESULTADOS: Encontramos mayor frecuencia genotípica de heterocigotos para el polimorfismo MTHFR C677T en la población general venezolana, con excepción del grupo caucásico. El polimorfismo MTHFR A1298C en el 70% de la población de estudio es homocigoto de tipo salvaje, encontrándose una baja frecuencia de homocigoto mutado. CONCLUSIONES: Se encontraron diferencias significativas entre grupos étnicos, destacando la importancia del genotipado racial de estos polimorfismos en la población venezolana.
The Dynamics of Employee Performance: Motivation and Discipline Perspectives
Authors: Ridwan Susan , Jusdijachlan
Published: January 2024

In the Secretariat of the Regional Representative Council (DPRD) of West Java Province, the study aims to simultaneously and partially investigate and analyze: (1) motivation; (2) work discipline; (3) employee performance; and (4) the effect of work motivation and discipline on employee performance. The staff at the Secretariat of the Regional Representative Council (DPRD) of West Java Province served as the unit of analysis in this study, with a sample size of 60 people. Frequency distribution and path analysis were used as the analytical techniques. The Secretariat of the Regional Representative Council (DPRD) of West Java Province's employees were deemed to have a high level of motivation, a high level of discipline, and a high level of employee performance based on the findings of the research and debate. Employee performance is influenced by both motivation and discipline at the same time, but motivation has a somewhat stronger influence than work discipline.
The Strategy Management in (Business) Organization
Authors: Nurpida Lisna
Published: January 2024

This paper presents strategic management as an important business managemen, Organizational levels, individuals truly formalize frameworks as a capacity to direct and focus their undertakings. In a business affiliation (a firm), such undertakings will focus in on making an impetus for benefit and coordinating the relationship towards future. The success of organizations is often attributed to effective business strategy. Affiliations really should learn and sort out the conditions as well as the communication for making feasible business procedure. Understanding what method really is and taking on the most effective way to manage cultivate strategy and large around as important as learning about how to make affiliations productive. Business philosophy has seen such endless changes in direction, highlight and approaches.
Enterprise Risk Management, the Balancing Act: Navigating Growth with Financial Health
Authors: Albert Albert , Wahid Ayi , Nengsih Widya , Prastyaningsih Nila
Published: January 2024

This study aims to determine the effect of Enterprise Risk Management (ERM), Company Size (SIZE), Debt to Equity Ratio (DER) and Profitability (ROA) on Company Value at BUMN Commercial Banks on the Indonesia Stock Exchange. The data used is secondary data and the method used is multiple linear regression analysis using the SPSS 20 program to obtain a comprehensive picture of the relationship between one variable and another. The sample of this study consisted of 4 banks from 2012 - 2019 using saturated sampling as a sampling method. The results of this study indicate that the ERM, Company Size and Profitability variables have a significant effect on the Value sometimes with a significance level of less than 5%, while DER partially has no significant effect. The results of simultaneous regression analysis show that ERM, SIZE, DER and ROA together affect Firm Value. The coefficient of determination (Adjusted R Square) of the results of this study is 0.665, which means that the four variables are able to influence 66.50% and the rest is influenced by other proportions that are not variables in this study
Diagnosis of Tuberculosis by Conventional and Molecular Methods in Our Laboratory: A 4-Year Assessment
Authors: ÖZTÜRK Cihadiye Elif , DÖNMEZ Betül , YILDIZ Pınar , ÇALIŞKAN Emel , UZAN ÇAKMAK Gulfidan
Published: January 2024

Objective: The aim of this study was to compare direct microscopy, culture and Polymerase Chain Reaction (PCR) methods and to present the antibiotic resistance profile of the last 4 years comparatively by conventional and molecular methods.

Materials and Methods: Bacterial culture, EZN and PCR methods were applied to all samples. Direct rapid resistance test was performed for EZN positive samples.

Results: 968 patients were included in the study. Culture was positive in 81 (8%), PCR in 78 (8%) and EZN in 39 (46%) patients. PCR performed on the same day in both respiratory and other samples showed very good agreement with culture, while EZN staining showed moderate agreement. It was observed that the rapid resistance test detected rifampicin resistance which was not detected in culture, and in the case of INH, culture antibiogram and rapid resistance test were fully compatible. Application of the rapid resistance test to every patient with positive EZN staining resulted in very early detection of resistance.

Conclusion: It was concluded that PCR tests are useful in the rapid diagnosis of tuberculosis and resistance in suspicious clinical samples.