bluuebunny/crossref_metadata_2025 huggingface dataset:
Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality
Authors: Lotfollahi Zahra , Mello Ana Paula de Queiroz , Costa Edna S. , Oliveira Cristiano L. P. , Damasceno Nagila R. T. , Izar Maria Cristina , Neto Antonio Martins Figueiredo
Published: July 2020

The aim of this study was to investigate the effects of 6-months consumption of green-banana biomass on the LDL particle functionality in subjects with type 2 diabetes. Subjects (n = 39, mean age 65 years old) of both sexes with diabetes (HbA1c ≥ 6·5%) were randomized to receive nutritional support plus green-banana biomass (40 g) (n = 21) or diet alone (n = 18) for 6-months. Non-linear optical responses of LDL solutions from these participants were studied by Z-scan technique. UV–visible spectrophotometer was used to measure the absorbance of the LDL samples. Small Angle X-ray Scattering and Dynamic Light Scattering experiments were used to look for any structural changes in LDL samples and to determine their size distribution. The Lipoprint test was used to determine the LDL sub-fractions in terms of distribution and size. Consumption of green-banana biomass, reduced total- (p = 0.010), non-HDL-cholesterol (p = 0.043), glucose (p = 0.028) and HbA1c (p = 0.0007), and also improved the protection of the LDL particle against oxidation, by the increase in carotenoids content in the particles (p = 0.007). This higher protection against modifications may decrease the risk of developing cardiovascular disease. These benefits of the green-banana biomass encourage the use of resistant starches with potential clinical applications in individuals with pre-diabetes and diabetes.
Carbon steel corrosion by bacteria from failed seal rings at an offshore facility
Authors: Salgar-Chaparro Silvia J. , Darwin Adam , Kaksonen Anna H. , Machuca Laura L.
Published: July 2020

Corrosion of carbon steel by microorganisms recovered from corroded seal rings at an offshore floating production facility was investigated. Microbial diversity profiling revealed that communities in all sampled seal rings were dominated by Pseudomonas genus. Nine bacterial species, Pseudomonas aeruginosa CCC-IOB1, Pseudomonas balearica CCC-IOB3, Pseudomonas stutzeri CCC-IOB10, Citrobacter youngae CCC-IOB9, Petrotoga mobilis CCC-SPP15, Enterobacter roggenkampii CCC-SPP14, Enterobacter cloacae CCC-APB1, Cronobacter sakazakii CCC-APB3, and Shewanella chilikensis CCC-APB5 were isolated from corrosion products and identified based on 16S rRNA gene sequence. Corrosion rates induced by the individual isolates were evaluated in artificial seawater using short term immersion experiments at 40 °C under anaerobic conditions. P. balearica, E. roggenkampii, and S. chilikensis, which have not been associated with microbiologically influenced corrosion before, were further investigated at longer exposure times to better understand their effects on corrosion of carbon steel, using a combination of microbiological and surface analysis techniques. The results demonstrated that all bacterial isolates triggered general and localised corrosion of carbon steel. Differences observed in the surface deterioration pattern by the different bacterial isolates indicated variations in the corrosion reactions and mechanisms promoted by each isolate.
Targeting the PLK1-FOXO1 pathway as a novel therapeutic approach for treating advanced prostate cancer
Authors: Gheghiani Lilia , Shang Shengzhe , Fu Zheng
Published: July 2020

The forkhead box protein O1 (FOXO1) is considered to be a key tumor suppressor due to its involvement in a broad range of cancer-related functions, including cellular differentiation, apoptosis, cell cycle arrest, and DNA damage. Given that inactivation of FOXO1 has been reported in many types of human cancer, we sought to investigate whether restoration of the pro-apoptotic activity of FOXO1 may be used as a new promising strategy for cancer treatment. Our previous study revealed that Polo-like kinase 1 (PLK1), a serine/threonine kinase that is essential for cell cycle progression, is a novel and major regulator of FOXO1 in the late phases of the cell cycle. Here, we provided evidence that PLK1-dependent phosphorylation of FOXO1 induces its nuclear exclusion and negatively regulates FOXO1′s transcriptional activity in prostate cancer (PCa). Blocking the PLK1-dependant phosphorylation of FOXO1 restored the pro-apoptotic function of FOXO1 in PCa. Combining PLK1 inhibition with nocodazole (to induce mitotic arrest) had synergistic antitumor effects in vitro, with minimal effect on normal prostate epithelial cells. These findings shed light on a novel approach to reactivate apoptotic pathways in advanced PCa and support targeting PLK1-FOXO1 pathways as a novel approach for treating advanced PCa.
Prevalence of neck/shoulder pain among public hospital workers in China and its associated factors: a cross-sectional study
Authors: Dong Hongyun , Zhang Qiong , Liu Guangzeng , Shao Tingguo
Published: July 2020

Studies have reported that neck and/or shoulder pain (NSP) was prevalent and a non-ignorable occupational health problem in healthcare providers. Considering data deficiency on NSP, we aimed to investigate the prevalence and sick leave absence of NSP among public hospital workers in Shandong, China and to explore the associated factors for chronic NSP. A self-administered questionnaire including the Dutch Musculoskeletal Questionnaire and Modified Nordic Musculoskeletal Questionnaire was filled in by 30,520 hospital workers in 37 hospitals selected randomly from among all public hospitals of Shandong, China. The 12-month prevalence of NSP lasting for at least 3 months and sick leave absence due to NSP among 29,547 public hospital workers was 15.6% and 11.4%, respectively, most frequently reported in tertiary hospital workers (27.4% and 18.9%) and clinicians (19.1% and 15.2%). Log-binomial regression analysis revealed that chronic NSP was significantly associated with hospital level, employment position, contract/temporary employment status (vs. permanent), workload (long work hours per week), ergonomic factors (bending the neck forward for long periods of time, twisting the neck for long periods of time) and computer-related factors (prolonged computer-using time daily, the keyboard too close to the edge of the desk).
Reoperations for structurally persistent or recurrent disease after thyroidectomy: analysis via preoperative CT
Authors: Kim Hyeung Kyoo , Ha Eun Ju , Han Miran , Lee Jeonghun , Soh Euy Young
Published: July 2020

The incidence rates of structural persistent disease (PD) and recurrent disease (RD) after thyroidectomy, and their clinicoradiological (CT) characteristics, remain poorly understood. Therefore, we characterized differentiated thyroid cancer (DTC) patients who underwent re-operations, with a focus on preoperative CT scans. We examined neck CT scans obtained prior to initial surgery and reoperation, and classified the disease into four categories according to the persistence/recurrence and neck dissection/non-dissection status. In total, 121 of 9,173 DTC patients underwent reoperations to treat PD or RD; the mean time to reoperation was 25.5 and 54.1 months, respectively. Of all reoperations, 19% (23/121) were performed to treat RD; 81% (98/121) were performed to treat PD. Compared to RD, PD was commonly detected in the non-dissected neck. Tumor multiplicity and the number of pathologically positive lymph nodes were greater in the non-dissected than dissected neck. A review of the CT data revealed more false-negative findings on the 60-s- versus 30–40-s-delay scans of PD patients with non-dissected necks. In conclusion, most of the reoperations performed on DTC patients were for management of PD. Improved preoperative CT assessments and initial surgery, based on the information of clinico-radiological characteristics, are required in the care of DTC patients.
Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells
Authors: Zogbi Camila , Oliveira Nathalia C. , Levy Débora , Bydlowski Sergio P. , Bassaneze Vinicius , Neri Elida A. , Krieger Jose E.
Published: July 2020

The nature of the early post-natal immune response in rodents appears to influence cardiac regeneration even though the underlying molecules remain poorly understood. Consistent with this idea, we show now significant changes in the expression of immune and cell movement gene pathways in heart samples from 1- and 7-day-old rats with ventricle resection. We then tested whether conditioned media from adult M2 anti-inflammatory macrophages target neonatal cardiac cells to a pro-regenerative like phenotype compared to the M1 pro-inflammatory macrophages. We found that M2 compared to M1 macrophage-conditioned media upregulates neonatal cardiomyocyte proliferation, suppresses myofibroblast-induced differentiation and stimulates endothelial cell tube formation. Using a cytokine array, we selected four candidate cytokine molecules uniquely expressed in M2 macrophage-conditioned media and showed that two of them (IL-4 and IL-6) induce endothelial cell proliferation whilst IL-4 promotes proliferation in neonatal cardiomyocytes and prevents myofibroblast-induced collagen type I secretion. Altogether, we provided evidence that adult M2 macrophage-conditioned media displays a paracrine beneficial pro-regenerative response in target cardiac cells and that IL-4 and IL-6 recapitulate, at least in part, these pleiotropic effects. Further characterization of macrophage immune phenotypes and their secreted molecules may give rise to novel therapeutic approaches for post-natal cardiac repair.
Realization of photonic charge-2 Dirac point by engineering super-modes in topological superlattices
Authors: Hu Mengying , Ding Kun , Qiao Tong , Jiang Xi , Wang Qiang , Zhu Shining , Liu Hui
Published: July 2020

Quite recently, an unconventional variety of fourfold linear band degeneracy points has been discovered in certain condensed-matter systems. Contrary to standard 3-D Dirac monopoles, these quadruple points known as the charge-2 Dirac points are characterized by nonzero topological charges, which can be exploited to delve into hitherto unknown realms of topological physics. Here, we report on the experimental realization of a charge-2 Dirac point by deliberately engineering hybrid topological states, called super-modes, in a 1-D optical superlattice system with synthetic dimensions. Utilizing direct reflection and transmission measurements, we propose the existence of the synthetic charge-2 Dirac point in the visible region. We also show an experimental approach to manipulating two spawned Weyl points possessing equal charge. Topological end modes resulting from the charge-2 Dirac point can be delicately controlled within truncated superlattices, opening a pathway to rationally engineer local fields with intense enhancement.
Enantiodivergent reduction of α-keto amides catalyzed by high valent, chiral oxido-vanadium(v) complexes
Authors: Agarwal Rachit , Liao Yiya , Lin Dai-Jen , Yang Zhen-Xing , Lai Chien-Fu , Chen Chien-Tien
Published: July 2020

Complementary asymmetric reductions of N-benzyl-α-keto amides were achieved for the first time by an air and moisture stable, reduced form of vanadyl(v) N-salicylidene-t-leucinate with HBPin and HBCat with up to 99% and 90% ee, respectively.
An adaptive ionic skin with multiple stimulus responses and moist-electric generation ability
Authors: Pan Xiaofeng , Wang Qinhua , Guo Runsheng , Cao Shilin , Wu Hui , Ouyang Xinhua , Huang Fang , Gao Haili , Huang Liulian , Zhang Fan , Chen Lihui , Ni Yonghao , Liu Kai
Published: July 2020

A low-cost ionic skin similar to natural skin was developed and it can achieve multiple sensing and moist-electric generation.
The application of isotopically labeled analogues for the determination of small organic compounds by GC/MS with selected ion monitoring
Authors: Caban Magda , Stepnowski Piotr
Published: July 2020

The study show the limitations and advantages of the use of stable isotope labeled internal standards (SILISs) for the quantification of small polar compounds (ibuprofen, diclofenac, metoprolol, bisphenol A, estradiol) in water samples by GC/MS (SIM).
The current role of mass spectrometry in forensics and future prospects
Authors: Brown Hilary M. , McDaniel Trevor J. , Fedick Patrick W. , Mulligan Christopher C.
Published: July 2020

A critical review of the role that mass spectrometry currently plays in forensic science is provided, as well as emerging techniques aimed at assisting the future forensic practitioner.
Dithioacetalization or thioetherification of benzyl alcohols using 9-mesityl-10-methylacridinium perchlorate photocatalyst
Authors: Pramanik Milan , Choudhuri Khokan , Mathuri Ashis , Mal Prasenjit
Published: July 2020

9-Mesityl-10-methylacridinium perchlorate as a visible-light photocatalyst is used for oxidative C–O bond functionalization of benzyl alcohols to either dithioacetals or thioethers in the presence of aerial oxygen as a terminal oxidant.
N,N-Diethyl-3-methylbenzamide (DEET) acts as a metal–organic framework synthesis solvent with phase-directing capabilities
Authors: Dodson Ryan A. , Kalenak Andre P. , Du Bois Derek R. , Gill-Ljunghammer Sasha L. , Matzger Adam J.
Published: July 2020

A variety of metal–organic frameworks typically synthesized in formamide solvents are produced in the insect repellent N,N-diethyl-3-methylbenzamide producing controlled-release composites.
Cathodic electrogenerated chemiluminescence of tris(2,2′-bipyridine)ruthenium(ii) and peroxydisulfate at pure Ti3C2Tx MXene electrodes
Authors: Zhang Jizhen , Kerr Emily , Usman Ken Aldren S. , Doeven Egan H. , Francis Paul S. , Henderson Luke C. , Razal Joselito M.
Published: July 2020

Two-dimensional transition metal carbide (Ti3C2Tx MXene) film as a novel electrode material for electrogenerated chemiluminescence of tris(2,2′-bipyridine)ruthenium(ii) and peroxydisulfate.
Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity
Authors: Kraevaya Olga A. , Novikov Artem V. , Shestakov Alexander F. , Ershova Elizaveta S. , Savinova Ekaterina A. , Kameneva Larisa V. , Veiko Nataliya N. , Schols Dominique , Balzarini Jan , Kostyuk Svetlana V. , Troshin Pavel A.
Published: July 2020

A fullerene derivative with phosphonic acid residues demonstrated promising activity against ten different viruses and the ability to promote myogenic differentiation of stem cells.
Discovery of sandwich type COVID-19 nucleocapsid protein DNA aptamers
Authors: Zhang Liyun , Fang Xiaona , Liu Xingbo , Ou Huichao , Zhang Haiyan , Wang Jinjun , Li Qian , Cheng Huanyi , Zhang Wenyi , Luo Zhaofeng
Published: July 2020

The sandwich-type DNA aptamers for COVID-19 N-protein have been developed and can be used as molecular tools for COVID-19 detection.
Collective enantioselective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B and (−)-lingzhiol: divergent reactivity of styrene
Authors: Zhang Da-Wei , Fan Hui-Lan , Zhang Wenzhao , Li Cheng-Ji , Luo Sanzhong , Qin Hong-Bo
Published: July 2020

The collective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B, (+)-lingzhilactone C and (−)-lingzhiol has been accomplished from a common epoxide intermediate 9.
Near-infrared electrochemiluminescence in water through regioselective sulfonation of diaza [4] and [6]helicene dyes
Authors: Li Haidong , Duwald Romain , Pascal Simon , Voci Silvia , Besnard Céline , Bosson Johann , Bouffier Laurent , Lacour Jérôme , Sojic Neso
Published: July 2020

A series of water-soluble helicene dyes generating intense electrochemiluminescence (ECL) signal in physiological conditions is reported.
The [2+2] cycloaddition product of perhalogenated cyclopentadienyl cations: structural characterization of salts of the [C10Cl10]2+ and [C10Br10]2+ dications
Authors: Rupf Susanne Margot , Pröhm Patrick , Malischewski Moritz
Published: July 2020

Perchlorinated and perbrominated organic dications [C10Cl10]2+ and [C10Br10]2+ have been obtained instead of monomeric cyclopentadienyl cations C5Cl5+ and C5Br5+.
FnCas12a/crRNA assisted dumbbell-PCR detection of IsomiRs with terminal and inner sequence variants
Authors: Wang Junyan , Bing Tao , Zhang Nan , Liu Xiangjun , Shangguan Dihua
Published: July 2020

A new FnCas12a/crRNA assisted Dumbbell-PCR (Cas-Db-PCR) method is developed for the detection of isomiR heterogeneity in length and/or sequence variants with high specificity and sensitivity.
Base-mediated cascade amidination/N-alkylation of amines by alcohols
Authors: Zhang Chunyan , Liang Zuyu , Lu Fenghong , Jia Xiaofei , Zhang Guoying , Hu Mao-Lin
Published: July 2020

An efficient base mediated N-alkylation with nitriles as a water acceptor was described, providing a convenient method to construct the different substituted diamino compounds, 15N labeled amine molecules and could scaled up to 1 mol scale.
Orientation loss of microcrystals of DyBa2Cu3Oyin a polymer composite during curing of the medium under an external magnetic field
Authors: Kimura Tsunehisa , Kashiwagi Hayato , Kimura Fumiko , Horii Shigeru , Takeda Kazuki , Doi Toshiya
Published: July 2020

The orientation loss of microcrystals during solidifying the matrix in a magnetic field was modeled.In situX-ray diffraction results obtained for the consolidation process of DyBa2Cu3Oymicrocrystal suspension were explained by the model presented.
Investigating the role of reducing agents on mechanosynthesis of Au nanoparticles
Authors: de Oliveira Paulo F. M. , Michalchuk Adam A. L. , Marquardt Julien , Feiler Torvid , Prinz Carsten , Torresi Roberto M. , Camargo Pedro H. C. , Emmerling Franziska
Published: July 2020

The influence of reducing agents on the mechanochemical synthesis of Au nanoparticles differ significantly from analogous solution syntheses. Environmentally benign mechanochemical syntheses of metal nanoparticles therefore require dedicated studies.
Examining the degradation of environmentally-daunting per- and poly-fluoroalkyl substances from a fundamental chemical perspective
Authors: Filho Antonio H. da S. , de Souza Gabriel L. C.
Published: July 2020

In this work, ground and excited-state properties were used as descriptors for probing mechanisms as well as to assess potential alternatives for tackling the elimination of per- and poly-fluoroalkyl substances (PFAS).
Sequential growth of iridium cluster anions based on simple cubic packing
Authors: Koyasu Kiichirou , Tomihara Ryohei , Nagata Toshiaki , Wu Jenna W. J. , Nakano Motoyoshi , Ohshimo Keijiro , Misaizu Fuminori , Tsukuda Tatsuya
Published: July 2020

Ion mobility measurements and DFT calculations revealed cubic growth of Irn− in contrast to fcc structures in bulk and nanoparticles.
Transient species of esculetin produced in pulse radiolysis: experimental and quantum chemical investigations
Authors: Deokar Rupali G. , Barik Atanu
Published: July 2020

Esculetin reacts with both oxidizing and reducing radicals produced by radiolysis. The transient products were identified from their distinctly different absorption spectra.
The effect of strong metal–support interaction (SMSI) on Pt–Ti/SiO2and Pt–Nb/SiO2catalysts for propane dehydrogenation
Authors: Zhu Chen Johnny , Gao Junxian , Probus Paige R. , Liu Wei , Wu Xianli , Wegener Evan C. , Kropf A. Jeremy , Zemlyanov Dmitry , Zhang Guanghui , Yang Xin , Miller Jeffrey T.
Published: July 2020

The selectivity of Pt NP's (gray) are modified by SMSI oxides (red) leaving exposed small ensembles capable of dehydrogenation, but with limited activity for hydrogenolysis.
Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise
Authors: Diaz-Castro Javier , Mira-Rufino Pablo Javier , Moreno-Fernandez Jorge , Chirosa Ignacio , Chirosa Javier Luis , Guisado Rafael , Ochoa Julio J.
Published: July 2020

Bone and energy metabolism are profoundly influenced by exercise.
Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea
Authors: Mazzarda Flavia , D'Elia Annunziata , Massari Roberto , De Ninno Adele , Bertani Francesca Romana , Businaro Luca , Ziraldo Gaia , Zorzi Veronica , Nardin Chiara , Peres Chiara , Chiani Francesco , Tettey-Matey Abraham , Raspa Marcello , Scavizzi Ferdinando , Soluri Alessandro , Salvatore Anna Maria , Yang Jun , Mammano Fabio
Published: July 2020

Using microfluidics, ATP biosensors, multiphoton microscopy and genetically targeted mice, we show that ATP release through connexin hemichannels, and not pannexin 1 channels, underlies spontaneous Ca2+ wave propagation in the greater epithelial ridge of the developing cochlea.
Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells
Authors: Ortiz-Otero Nerymar , Marshall Jocelyn R. , Lash Bradley W. , King Michael R.
Published: July 2020

Liposomal formulation to deliver TNF-related apoptosis-inducing ligand (TRAIL) to platelets via von Willebrand Factor (vWF) interaction. TRAIL-coated platelets killed circulating tumor cells (CTCs) in the bloodstream to reduce cancer metastasis.
Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications
Authors: Lim Jason Y. C. , Yu Yong , Jin Guorui , Li Kai , Lu Yi , Xie Jianping , Tan Yen Nee
Published: July 2020

Decoding empirical design rules of DNA templates for customizable synthesis of ultrasmall silver nanoclusters with predictable photoluminescence and cell-targeting properties.
Effect of alkaline earth metal chloride additives BCl2 (B = Mg, Ca, Sr and Ba) on the photovoltaic performance of FAPbI3 based perovskite solar cells
Authors: Lyu Mei , Lee Do-Kyoung , Park Nam-Gyu
Published: July 2020

Divalent cation-containing alkaline earth metal halides BCl2 (B = Mg, Ca, Sr, Ba) are used as additives in precursor solutions, where addition of MgCl2 improves photovoltaic performance of FAPbI3 based perovskite solar cell.
Field induced slow magnetic relaxation in a zig-zag chain-like Dy(iii) complex with the ligando-phenylenedioxydiacetato
Authors: Černák Juraj , Harčárová Katarína , Falvello Larry R. , Dlháň Ľubor , Titiš Ján , Boča Roman
Published: July 2020

Three relaxation channels in field-induced SMM [Dy(PDOA)(NO3)(H2O)2]n·nH2O with DyO9chromophore.
The photo-/thermo-chromism of spiropyran in alkanes as a temperature abuse indicator in the cold chain of vaccines
Authors: Gao Mei , Lian Chaofan , Xing Rang , Wang Jie , Wang Xuefei , Tian Zhiyuan
Published: July 2020

Color change related to the phase change of spiropyran–merocyanine system can indicate temperature changes in vaccine transportation.
Large-area periodic arrays of gold nanostars derived from HEPES-, DMF-, and ascorbic-acid-driven syntheses
Authors: Demille Trevor B. , Hughes Robert A. , Dominique Nathaniel , Olson Jacob E. , Rouvimov Sergei , Camden Jon P. , Neretina Svetlana
Published: July 2020

A method for the nanofabrication of periodic arrays of gold nanostars yielding a unique morphology of relevance to SERS applications.
Calcium-responsive hydrogels enabled by inducible protein–protein interactions
Authors: Luo Jiren , Sun Fei
Published: July 2020

Creation of an entirely protein-based calcium-responsive hydrogel enabled by genetically encoded click chemistry (GECC) and inducible protein–protein interactions.
Highly efficient UV-Vis light activated three-component photoinitiators composed of tris(trimethylsilyl)silane for polymerization of acrylates
Authors: Balcerak Alicja , Kwiatkowska Dominika , Iwińska Katarzyna , Kabatc Janina
Published: July 2020

The goal of this paper concerns the evaluation of the efficiency of novel three-component systems for initiating the photopolymerization process of 2-ethyl-2-(hydroxymethyl)-1,3-propanediol triacrylate (TMPTA).
Functional nanostructures by NiCCo-PISA of helical poly(aryl isocyanide) copolymers
Authors: Jimaja Sètuhn , Xie Yujie , Foster Jeffrey C. , Taton Daniel , Dove Andrew P. , O'Reilly Rachel K.
Published: July 2020

Nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) as a straightforward and versatile methodology to achieve functional helix-containing polymeric nano-objects.
Anticancer potency of novel organometallic Ir(iii) complexes with phosphine derivatives of fluoroquinolones encapsulated in polymeric micelles
Authors: Kozieł Sandra , Komarnicka Urszula K. , Ziółkowska Aleksandra , Skórska-Stania Agnieszka , Pucelik Barbara , Płotek Michał , Sebastian Victor , Bieńko Alina , Stochel Grażyna , Kyzioł Agnieszka
Published: July 2020

A 3D model of cell culturing (spheroids) was explored and the anticancer potential of the selected novel organometallic Ir(iii) complex encapsulated in Pluronic p-123 micelles was clearly proved.
Hydride transfer enabled switchable dearomatization of indoles in the carbocyclic ring and the pyrrole ring
Authors: Duan Kang , Shi Hongjin , Wang Lin-Xuan , Li Shuai-Shuai , Xu Lubin , Xiao Jian
Published: July 2020

Hydride transfer enabled the first success of the regioselective dearomatization of indoles in the carbocyclic ring and the pyrrole ring, which was induced by ortho-quinone methides and vinylogous iminium intermediates, respectively.
AIBN for Ru-catalyzed meta-CAr–H alkylation
Authors: Yang Suling , Yan Bingxu , Zhong Lei , Jia Chunqi , Yao Dan , Yang Chunli , Sun Kai , Li Gang
Published: July 2020

The meta-CAr–H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl3 catalyst is presented.
Flower-like hydrogen titanate nanosheets: preparation, characterization and their photocatalytic hydrogen production performance in the presence of Pt cocatalyst
Authors: Dong Feng , Zhang Guoqing , Guo Yuan , Zhu Baolin , Huang Weiping , Zhang Shoumin
Published: July 2020

Hydrogen titanate nanosheets were assembled into the flower-like hydrogen titanate nanosheets to obtain high photocatalytic performance.
Comparative study on different strategies for synthesizing all-silica DD3R zeolite crystals with a uniform morphology and size
Authors: Peng Anna , Lu Xinqing , Ma Rui , Fu Yanghe , Wang Shuhua , Zhu Weidong
Published: July 2020

A facile protocol was developed to synthesize pure DD3R crystals with a controllable morphology and size, as well as high reproducibility and productivity.
Role of defects on TiO2/SiO2 composites for boosting photocatalytic water splitting
Authors: Saputera Wibawa Hendra , Rizkiana Jenny , Wulandari Winny , Sasongko Dwiwahju
Published: July 2020

Defect engineering of semiconductor photocatalysts is considered as an evolving strategy to adjust their physiochemical properties and boost photoreactivity of the materials.
Competition between N and O: use of diazineN-oxides as a test case for the Marcus theory rationale for ambident reactivity
Authors: Sheehy Kevin J. , Bateman Lorraine M. , Flosbach Niko T. , Breugst Martin , Byrne Peter A.
Published: July 2020

Marcus theory enables rationalisation and quantification of selectivities in reactions of ambident nucleophiles for which the HSAB principle cannot operate.
A Janus 3D DNA nanomachine for simultaneous and sensitive fluorescence detection and imaging of dual microRNAs in cancer cells
Authors: Yang Zezhou , Peng Xin , Yang Peng , Zhuo Ying , Chai Ya-Qin , Liang Wenbin , Yuan Ruo
Published: July 2020

A Janus three-dimensional DNA nanomachine was constructed for the simultaneous and sensitive fluorescent detection and imaging of dual microRNAs in the cancer cells.
Two-step yielding behavior of densely packed microgel mixtures with chemically dissimilar surfaces and largely different sizes
Authors: Minami Saori , Watanabe Takumi , Sasaki Yuma , Minato Haruka , Yamamoto Atsushi , Suzuki Daisuke , Urayama Kenji
Published: July 2020

The concentrated microgel mixtures with chemically dissimilar surfaces and large size disparity exhibit two-step yielding due to the characteristic packing.
Fluorescent patterning of paper through laser engraving
Authors: Clark Kaylee M. , Skrajewski Lauren , Benavidez Tomás E. , Mendes Letícia F. , Bastos Erick L. , Dörr Felipe A. , Sachdeva Rakesh , Ogale Amod A. , Paixão Thiago R. L. C. , Garcia Carlos D.
Published: July 2020

Thermal treatment of paper leads to the formation of aromatic structures, allowing patterning the substrates and their use as sensors.
Aggregation, liquid–liquid phase separation, and percolation behaviour of a model antibody fluid constrained by hard-sphere obstacles
Authors: Hvozd Taras , Kalyuzhnyi Yurij V. , Vlachy Vojko
Published: July 2020

The presence of hard-sphere obstacles strongly decreases the critical density and also, but to a much lesser extent, the critical temperature.
Inducing ordered Li deposition on a PANI-decorated Cu mesh for an advanced Li anode
Authors: Hu Xin-Yu , Xu Pan , Deng Shengwen , Lei Jie , Lin Xiaodong , Wu Qi-Hui , Zheng Mingsen , Dong Quanfeng
Published: July 2020

The lithiophilic PANI micro-sheets can induce Li+ to gather around the conductive matrix, thus a well-aligned Li deposition can be achieved.
A novel multifunctional FePt/BP nanoplatform for synergistic photothermal/photodynamic/chemodynamic cancer therapies and photothermally-enhanced immunotherapy
Authors: Yao Xiuxiu , Yang Baochan , Wang Shan , Dai Zhichao , Zhang Dongsheng , Zheng Xiuwen , Liu Qingyun
Published: July 2020

A new multi-modal therapy agent FePt/BP–PEI–FA NCs, with FePt nanoparticles (FePt NPs) loaded onto ultrathin black phosphorus nanosheets (BPNs), has been constructed to enhance synergistic PTT, PDT and CDT that target primary tumors.
Identification of cell division cycle 20 as a candidate biomarker and potential therapeutic target in bladder cancer using bioinformatics analysis
Authors: Shen Peilin , He Xuejun , Lan Lin , Hong Yingkai , Lin Mingen
Published: July 2020

Purpose: As bladder cancer (BC) is very heterogeneous and complicated in the genetic level, exploring genes to serve as biomarkers and therapeutic targets is practical.

Materials and methods: We searched Gene Expression Omnibus (GEO) and downloaded the eligible microarray datasets. After intersection analysis for identified differentially expressed genes (DEGs) of included datasets, overlapped DEGs were identified and subsequently analyzed with Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Protein–Protein Interaction (PPI) and hub genes identification. Hub genes were further analyzed with mRNA expression comparation in Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) database, proteomics-based validation in The Human Protein Atlas (THPA) and survival analysis in GEO and Oncolnc database.

Results: We analyzed five eligible GEO datasets and identified 76 overlapped DEGs mapped into PPI network with 459 edges which were mainly enriched in cell cycle pathway and related terms in GO and KEGG analysis. Among five identified hub genes, which are Cyclin-Dependent Kinase 1 (CDK1), Ubiquitin-Conjugating Enzyme E2 C (UBE2C), Cell Division Cycle 20 (CDC20), Microtubule Nucleation Factor (TPX2) and Cell Division Cycle Associated 8 (CDCA8); CDC20 and CDCA8 were confirmed as significant in mRNA expression comparation and proteomics-based validation. However, only CDC20 was considered prognostically significant in both GEO and Oncolnc database.

Conclusions: CDC20 and CDCA8 were identified as candidate diagnostic biomarkers for BC in the present study; however, only CDC20 was validated as prognostically valuable and may possibly serve as a candidate prognostic biomarker and potential therapeutic target. Still, further validation studies are essential and indispensable.
Discovery of new stellar groups in the Orion complex
Authors: Chen Boquan , D’Onghia Elena , Alves João , Adamo Angela
Published: July 2020

We test the ability of two unsupervised machine learning algorithms,EnLinkand Shared Nearest Neighbor (SNN), to identify stellar groupings in the Orion star-forming complex as an application to the 5D astrometric data fromGaiaDR2. The algorithms represent two distinct approaches to limiting user bias when selecting parameter values and evaluating the relative weights among astrometric parameters.EnLinkadopts a locally adaptive distance metric and eliminates the need for parameter tuning through automation. The original SNN relies only on human input for parameter tuning so we modified SNN to run in two stages. We first ran the original SNN 7000 times, each with a randomly generated sample according to within-source co-variance matrices provided inGaiaDR2 and random parameter values within reasonable ranges. During the second stage, we modified SNN to identify the most repeating stellar groups from the 25 798 we obtained in the first stage. We recovered 22 spatially and kinematically coherent groups in the Orion complex, 12 of which were previously unknown. The groups show a wide distribution of distances extending as far as about 150 pc in front of the star-forming Orion molecular clouds, to about 50 pc beyond them, where we, unexpectedly, find several groups. Our results reveal the wealth of sub-structure in the OB association, within and beyond the classical Blaauw Orion OBI sub-groups. A full characterization of the new groups is essential as it offers the potential to unveil how star formation proceeds globally in large complexes such as Orion.
GJ 357 b
Authors: Modirrousta-Galian D. , Stelzer B. , Magaudda E. , Maldonado J. , Güdel M. , Sanz-Forcada J. , Edwards B. , Micela G.
Published: July 2020

Aims. In this paper we present a deep X-ray observation of the nearby M dwarf GJ 357 and use it to put constraints on the atmospheric evolution of its planet, GJ 357 b. We also analyse the systematic errors in the stellar parameters of GJ 357 in order to see how they affect the perceived planetary properties.

Methods. By comparing the observed X-ray luminosity of its host star, we estimate the age of GJ 357 b as derived from a recent XMM-Newton observation (log Lx [erg s−1] = 25.73), with Lx− age relations for M dwarfs. We find that GJ 357 presents one of the lowest X-ray activity levels ever measured for an M dwarf, and we put a lower limit on its age of 5 Gyr. Using this age limit, we performed a backwards reconstruction of the original primordial atmospheric reservoir. Furthermore, by considering the systematic errors in the stellar parameters, we find a range of possible planetary masses, radii, and densities.

Results. From the backwards reconstruction of the irradiation history of GJ 357 b’s we find that the upper limit of its initial primordial atmospheric mass is ~38 M⊕. An initial atmospheric reservoir significantly larger than this may have survived through the X-ray and ultraviolet irradiation history, which would not be consistent with current observations that suggest a telluric composition. However, given the relatively small mass of GJ 357 b, even accreting a primordial envelope ≳10 M⊕ would have been improbable as an unusually low protoplanetary disc opacity, large-scale migration, and a weak interior luminosity would have been required. For this reason, we discard the possibility that GJ 357 b was born as a Neptunian- or Jovian-sized body. In spite of the unlikelihood of a currently existing primordial envelope, volcanism and outgassing may have contributed to a secondary atmosphere. Under this assumption, we present three different synthetic IR spectra for GJ 357 b that one might expect, consisting of 100% CO2, 100% SO2, and 75% N2, 24% CO2 and 1% H2O, respectively. Future observations with space-based IR spectroscopy missions will be able to test these models. Finally, we show that the uncertainties in the stellar and planetary quantities do not have a significant effect on the estimated mass or radius of GJ 357 b.
Low-cost precursor of an interstellar mission
Authors: Heller René , Anglada-Escudé Guillem , Hippke Michael , Kervella Pierre
Published: July 2020

The solar photon pressure provides a viable source of thrust for spacecraft in the solar system. Theoretically it could also enable interstellar missions, but an extremely small mass per cross section area is required to overcome the solar gravity. We identify aerographite, a synthetic carbon-based foam with a density of 0.18 kg m−3 (15 000 times more lightweight than aluminum) as a versatile material for highly efficient propulsion with sunlight. A hollow aerographite sphere with a shell thickness ϵshl  =  1 mm could go interstellar upon submission to solar radiation in interplanetary space. Upon launch at 1 AU from the Sun, an aerographite shell with ϵshl  =  0.5 mm arrives at the orbit of Mars in 60 d and at Pluto’s orbit in 4.3 yr. Release of an aerographite hollow sphere, whose shell is 1 μm thick, at 0.04 AU (the closest approach of the Parker Solar Probe) results in an escape speed of nearly 6900 km s−1 and 185 yr of travel to the distance of our nearest star, Proxima Centauri. The infrared signature of a meter-sized aerographite sail could be observed with JWST up to 2 AU from the Sun, beyond the orbit of Mars. An aerographite hollow sphere, whose shell is 100 μm thick, of 1 m (5 m) radius weighs 230 mg (5.7 g) and has a 2.2 g (55 g) mass margin to allow interstellar escape. The payload margin is ten times the mass of the spacecraft, whereas the payload on chemical interstellar rockets is typically a thousandth of the weight of the rocket. Using 1 g (10 g) of this margin (e.g., for miniature communication technology with Earth), it would reach the orbit of Pluto 4.7 yr (2.8 yr) after interplanetary launch at 1 AU. Simplistic communication would enable studies of the interplanetary medium and a search for the suspected Planet Nine, and would serve as a precursor mission to α Centauri. We estimate prototype developments costs of 1 million USD, a price of 1000 USD per sail, and a total of < 10 million USD including launch for a piggyback concept with an interplanetary mission.
Applied Research on the Design of Signage and Wayfinding System of Historic Blocks from the Perspective of Urban Culture
Authors: Ma Xiaoqing , Li Min , Wang Jicong , Wang Jia
Published: July 2020

With the continuous improvement of spiritual and cultural needs, the main reason why people are keen on traveling is that they want to learn about the cultural deposits of the scenic spots. Under this context, this paper takes the signage and wayfinding System of historical blocks as the research object, emphasizes the necessity of extracting urban cultural information and applying it to the signage and wayfinding system design, analyzes the problems existing in the signage and wayfinding system of historical blocks and the application value of urban culture in the signage and wayfinding system of historical blocks. Finally, from the perspective of urban culture, this paper puts forward a suggestion that the design of signage and wayfinding system of historical blocks shall take the characteristics of local buildings, regional styles and folk culture elements as the introduction points.
Design and Research of New High-efficiency Seed Removal Roller for Sunflower Seed Remover
Authors: Liu Wenming , An Lele
Published: July 2020

Based on the working principle of sunflower seed remover, this paper studies the existing de-seeding of sunflower seed remover in China. Through analysis, it is found that the main reasons for the sunflower seed remover’s low efficiency are the low removal rate, high crushing rate and low cleanliness. Based on the analysis, the reason is obtained. With the improvement of sunflower seed removal roller, the problems of low efficiency and high failure rate of seed removal machine were solved. A new type of combined sunflower seed remover was designed, and through the related experiment research proves that this new type of combined sunflower seed remover can improve the work efficiency of the seed remover.
Research on Maritime Silk Road-based Product Integration under Metaphorical Cognitive Framework
Authors: Qinying Xin
Published: July 2020

The hierarchy-based metaphorical cognitive framework is constructed to integrate the product design with the Maritime Silk Road culture of southern Fujian via channels including cultural symbols, its utilization as well as connotations involved. Specifically, integration of various elements along with expanded functions and details could further reveal the charm of cultural designs. Such practices could serve a way to testify the efficiency of these designs in cultural communication, thus providing references for the teaching of cultural and creative product design as well as product designs by factories.
Research on Innovative Design of Lei Feng’s Cultural and Tourism Souvenirs
Authors: Gao Hong-he , Han Lu
Published: July 2020

Lei Feng’s cultural tourist souvenirs are designed to meet the aesthetic needs of the young people. By purchasing red tourist souvenirs, consumers can enhance their understanding and communication of Lei Feng’s spiritual culture, promote them social positive energy and promote regional tourism economic growth. According to the design principles and methods of red tourist souvenirs, the image features of Lei Feng and related red cultural features are accurately extracted, and combined with the current development status of red tourist souvenir market, the organic combination of Lei Feng and related red elements and tourist souvenirs is achieved. In view of the current lack of cultural design of Lei Feng tourist souvenirs. Through in-depth investigation and analysis of red elements related to lei Feng’s tourist souvenirs that can deeply reflect the spirit and culture of Lei Feng.
Cultural Creative Product Design from the Perspective of Chinese Ancient Ware Modelling
Authors: Du HeMin
Published: July 2020

As a high value-added product, cultural creative products emphasize the cultural connotation of products. Taking tourist souvenirs as an example, the country vigorously develops the green economy represented by tourism, which drives the rise of cultural creative product design. How to design excellent cultural creative products has become a realistic topic. Ancient Chinese artefacts have inherited and accumulated a long tradition of culture, and shaped excellent creative products worthy of our learning and reference. This paper discusses the cultural connotation, cultural integration and humanistic thoughts of the design of ancient Chinese artefacts and provides useful ideas for the design of cultural creative products today.
Interaction Design of Office Supplies Based on GTD
Authors: Gan Yurong , Jiang Aijuan , Heng Li
Published: July 2020

In daily study and work, there are some people who complain about procrastination and how to change from an ill-adapted procrastination patient to the adaptive procrastination to improve the efficiency of work by using procrastination. This paper studies the procrastination crowd, analyzes the cause of procrastination anxiety, and puts forward a method based on management time-GTD (Getting Things Done) designs a set of office supplies design combining software and hardware from the point of view of product design. Hopefully, through the core principles of GTD: collection, collation, organization, review, and execution of a series of steps to procrastinate patients at a certain stage Solve or alleviate the bad factors caused by procrastination in order to improve the efficiency of the work.
Research on the Innovative Approach of Intergrowth of Xipi Lacquer Art in Huizhou and Modern Product Design
Authors: Sun Fuliang , Shu Wei
Published: July 2020

Xipi Lacquer Art in Huizhou was once well-known all over China with the brilliant Huizhou merchants and it was once also annihilated in the river of long history. The surface of Huizhou Xipi Lacquer Art is so bright that it can serve as a mirror, and the swirling, complicated and changing patterns endow it with mysterious and gorgeous beauty. In modern times, since the technique of Huizhou Xipi Lacquer Art recovered all that was lost, its special aesthetic sense of beauty and the craftsman’s pursuit of superlative craftsmanship have led to the increasing emphasis on the objects produced by it for people to appreciate. This deviates from the public’s demand for stable quality and economic utility, and it is difficult to integrate into the consumer market. In this paper, through the in-depth analysis of the history and context of Huizhou Xipi Lacquer Art, the author combines with the theory of contemporary product design to explore the advantages and disadvantages of Huizhou Xipi Lacquer Art into modern product design. Besides, the author uses the scientific research method to find a breakthrough for the two symbiosis and concludes the approach to realize the innovation and development of the excellent traditional technology in the era of science and technology.
Analysis of functions of healthy office furniture based on analytic hierarchy process
Authors: Chunpeng Wang , Qing Xu
Published: July 2020

In this digital information age, electronic devices can improve the work efficiency and reduce work load in business, but sedentary and long-time work style undermines the health of white-collar workers in the office. By combining qualitative and quantitative analysis, we aimed to identify the factors affecting health of white-collar workers in the office. Based on user demands, we summarized the design concepts for office furniture, pre-selected functions of the furniture, built a layered function model for healthy office furniture, and performed weight calculation on the criterion layer and the measure layers. The analytic hierarchy process method was used to sequence the functions of healthy office furniture to provide new design ideas and a basis for design of healthy office furniture.
Research on the Development and Future Trend of Office Furniture Design
Authors: Fan Yueyun , Jin Yinhui
Published: July 2020

Technological innovation and social development have caused huge changes in people’s demand for office space. The development of the Internet of things, interaction design, and experience design has played an important role in the design research of office furniture in the future. In order to adapt the future office furniture design to the theme of the development of the times, this article uses the method of Literature review to understand the development history of office furniture design, and comparatively analyses the current situation of office furniture diversification through Case study, and analyses the future trend of office furniture design.
Reform on Teaching Modes of the Design Major in Universities Driven by Actual Projects——Taking Practice Teaching of Product Design as An Example
Authors: Bai Shi , Jin Xin
Published: July 2020

With the continuous development and upgrades of the design industry, design courses in colleges and universities should advance with the times. In teaching, there are indeed many courses that lose touch with practical applications. Especially in practice teaching, they are disconnected from the designing requirements of the actual projects in the industry. For instance, the contents and modes of teaching deviate from the actual requirements. Based on the contents and teaching modes of practice courses for product design in this paper, the status of teaching is analyzed to strategies for course construction. It aims to promote the practice teaching of product design to better meet the actual demands for the development of the industry and the goals of system.
Design of Munitions Visibility Management System
Authors: Bai Yu , Zhang Jingchen , Qin Xiangyu
Published: July 2020

Munitions are one of the most critical and sensitive assets in the military supply chain, and its supply in the battlefield can greatly affect the result of the war. Historical data show that military forces are often provided either too much or too little ammunition because of the lack of visibility. This paper introduces the Munitions Visibility Management System that contains two parts, an organizational system and a technological system. The former one is from the administrative angle to standardize and control, and the latter one is from the technological angle to integrate and implement technologies needed. It gives a new way in studying the management of munitions.