bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of Mobile Phone Addiction and Mental Health among Adolescent Girls Studying in Various Streams
Authors: Shaikh Ajhar Shaikh Abdul Wahed Patel  , Dr. Parmeshwsar Abhiman Puri
Published: September 2020

Present research aims to study mobile phone addiction and mental health among adolescent girls studying in various streams. The study employed survey method of research. Total 150 adolescent girls studying in Arts, Science and Commerce stream of Aurangabad city was selected by Random Sampling method as the sample of the study. Sample consists of 50 adolescent girls from each stream. Tools used for the research were Mobile phone addiction test by Dr.S.Velayudhan and Dr.S.Srividya and Mental Health Checklist (MHC) by Pramod Kumar .Statistical measures used for data analysis was Mean, SD, and ANNOVA and Pearson’s Product Moment Method of Correlation. Results revealed that there is significant difference between the level mobile phone addiction of adolescent girls studying in various streams. No significant difference was found between the level mental health among adolescent girls studying in various streams. Positive and significant correlation was found between mobile phone addiction and mental health which predicts that higher the level of mobile phone addiction lower will be the mental health. Suggestions were given to reduce mobile phone addiction and improve mental health among adolescent girls.
Sexual Desire and Materialism as Predictors of Marital Satisfaction among Men
Authors: Seema Vinayak  , Bita Noktehdan  , Rohin Vinayak
Published: September 2020

Background and aim: Considering the importance of marital satisfaction in married life and its relation to health and happiness, this research aimed to investigate the role of sexual desire and materialism in marital satisfaction among Iranian males. Method: In this study, 240 married males in the age range of 25-46 years were selected randomly among the employees in government sections in Tehran-Iran. The participants responded to standard questionnaires of Hurlburt Index of Sexual Desire, Material Values Scale and Enrich marital satisfaction. Correlation and Regression analysis were done. Results: Results indicated that sexual desire was positively related to marital satisfaction. Negative relationship occurred between materialism and marital satisfaction. The study revealed that sexual desire and materialism emerged as predictors of marital satisfaction. Conclusion: Inconsistent with previous findings, a significant relationship emerged between materialism and marital satisfaction as well as sexual desire. These factors can play an important role in family therapy and happiness.
Ações de prevenção de contágio do novo coronavírus em um centro integrado de inclusão e reabilitação: relato de experiência
Authors: Pinheiro Leisson Domingues , Junior Ricardo Gomes , Neto José Luz Batista , Reyes Paola Alejandra Valenzuela , Fernandes Nayara cavalcante , Quintino Claudete Ferreira , Maciel Fabrícia Dias
Published: September 2020

Objetivo: Relatar a experiência da implantação de ações coordenadas em um Centro Integrado de Inclusão e Reabilitação para prevenção ao novo Coronavírus. Relato de experiência: Este estudo constitui um relato de experiência de caráter descritivo da implantação de ações coordenadas para prevenção do novo coronavírus seguindo as recomendações sanitárias federal, estadual e municipal. Entre as ações implantadas do comitê de crise, backup de atividades assistenciais, protocolos clínicos, material de comunicação, acompanhamento de psicológicos para colaboradores e realização de teste. Considerações finais: O centro adotou todas as medidas orientadas pelos órgãos sanitários, implantando de forma organizada as ações e multiplicando informações entre os colaboradores, usuários e familiares. É importante implantar uma política de testagem em massa. Possivelmente teríamos um mapa epidemiológico mais confiável para análise, colocando em pauta também as discussões socioeconômicas que são bastante distintas no Brasil. O momento é reunir todas as opiniões e a criatividade para combater esse vírus.
Indicações para fins terapêuticos da toxina botulínica do tipo A no uso odontológico: uma revisão de literatura
Authors: Da Silva Alan Alves , Filho Dalmario Gaia Nepomuceno , Bomfim Lucas Magalhães , Silva Lívia Adélia Mendes , Cunha Mirella Soares da , De Albuquerque Savana Costa , Da Rocha Weizia Gomes , Lima Monaly de Oliveira , Duque Ana Fernanda Cumarú , Neto João Francisco Tenório
Published: September 2020

Objetivos: Esse estudo tem como foco efetuar uma revisão de literatura a respeito das indicações para fins terapêuticos da utilização da toxina botulínica do tipo A no uso odontológico para o tratamento de pacientes que apresentam bruxismo e sorriso gengival em excesso. Métodos: Foi efetivada uma revisão de literatura, tendo como forma de abordagem aspecto descritivo com caráter informativo, em que o processo de construção ocorreu através de pesquisas presentes em acervos científicos, apresentando como descritores: A utilização da toxina botulínica como fins terapêuticos, utilização no bruxismo e toxina botulínica tipo A para correções gengivais. Resultados: Visando amenizar os problemas relacionados ao bruxismo e ao sorriso gengival devolvendo ao paciente não só fins estéticos, como terapêuticos, destaca-se a utilização da toxina botulínica, por se tratar de um procedimento não invisível e de resultado imediato. Conclusão: A toxina botulínica do tipo A, é uma escolha de primeiro instante ao que se trata de procedimentos terapêuticos, possui um resultado satisfatório em pouco tempo, devido o controle da hiperatividade da musculatura do masseter e do temporal, sendo de fácil manuseio pelos Cirurgiões-dentistas qualificados.
Guia ilustrado para mediar educação em saúde com pessoas após o acidente vascular cerebral: construção e validação de conteúdo
Authors: Galvão Renata de Oliveira , Teixeira Elizabeth , Nemer Camila Rodrigues Barbosa
Published: September 2020

Objetivo: validar o conteúdo de um guia ilustrado para mediar educação em saúde com pessoas após o acidente vascular cerebral. Métodos: pesquisa metodológica, constituída em revisão da literatura; construção do guia ilustrado; e, validação de conteúdo com 19 juízes-especialistas da área da saúde e de outras áreas. Foram aplicados dois questionários distintos, os dados em estatística descritiva passaram para análise quantitativa no Índice de Validade de Conteúdo e no Escore SAM. Resultados: O Índice de Validade de Conteúdo encontrado foi de 0,79. O Escore SAM foi de 26 pontos. As sugestões obtidas dos juízes-especialistas indicaram ser necessário mais informações sobre afecções crônicas e autocuidado, bem como a inclusão de informações sobre disfagia e marcha, em função da qualidade de vida após evento vascular. Conclusão: posterior a validação, o guia ilustrado evidenciou-se um dispositivo adequado para mediar ações de educação em saúde com pessoas acometidas por alterações neurológicas devido ao acidente vascular cerebral.
Abordagem sobre as principais mudanças e cuidados no manejo odontológico frente ao novo Coronavírus
Authors: Bastos Mariana Rezende Oliveira , Bastos Nayara Rezende Oliveira
Published: September 2020

Objetivo: Abordar sobre as principais mudanças e cuidados no manejo odontológico frente ao enfrentamento do novo Coronavírus. Revisão bibliográfica: Os cirurgiões-dentistas foram considerados profissionais com grande risco de infecção cruzada pelo COVID-19, pois estão em contato direto com aerossóis, fluidos de pacientes e materiais contaminados. É necessária uma mudança no manejo odontológico, reforçando os equipamentos de proteção pessoal, limpeza e escolha de procedimentos que diminuam a chance de contágio viral. O profissional deve estar apto a reconhecer e selecionar os pacientes que necessitam de atendimento presencial, seguindo os protocolos recomendados pelos órgãos de saúde. São necessários mais estudos acerca do SARS-CoV-2, pois ainda se desconhece todo o seu comportamento. Considerações finais: Os profissionais da Odontologia devem seguir todas as mudanças propostas no manejo de pacientes em época do novo Coronavírus, reforçando a biossegurança, dando prioridade a procedimentos que não gerem aerossóis, triando pacientes, diminuindo assim o risco de infecção cruzada.
An Atypical Presentation of Pemphigus Vegetans in the Umbilicus
Authors: Jimenez Antonio , Hoyer Paige , Wilkerson Michael
Published: September 2020

Pemphigus is a chronic, autoimmune bullous disease that affects the skin and mucous membranes. Pemphigus vegetans is a rare variant of pemphigus and presents as oral ulcerations with associated verrucous lesions in intertriginous or flexural areas. A 38-year-old African American woman presented to the clinic with a chief complaint of oral ulcers. She carried a diagnosis of Behcet’s disease and was referred by rheumatology for evaluation of treatment-resistant mucosal ulcerations. At the time of her dermatology visit, she also reported an enlarging umbilical mass that had been present for several months.  Further examination of the umbilical lesion identified an exophytic, vegetative mass. Histologic assessment of the lesion identified acanthosis and acantholysis with dermal eosinophils consistent with pemphigus vegetans. A pemphigus antibody panel was done and resulted positive for IgG desmoglein-3 antibodies. The patient was treated with prednisone and rituximab with improvement of her lesions. We present an atypical presentation of pemphigus vegetans involving the umbilicus. This diagnosis should be considered in patients who present with oral erosions and concomitant vegetative lesions, regardless of location or prior diagnoses.
Extensive Tinea Associated with Tofacitinib Therapy Masquerading as New-Onset SCLE
Authors: Buechler Connor R , Kurland Elena , Veenstra Jesse
Published: September 2020

Rheumatoid arthritis is a chronic autoimmune disorder that often requires treatment with immunomodulatory agents, however, such interventions are not without risk of opportunistic infection.  Monitoring for such conditions is critical, whereas recognition and treatment can prove challenging at times, as they may manifest with an atypical presentation or masquerade as another condition entirely. We present here a case of extensive tinea corporis with concomitant tinea capitis masquerading as new-onset connective tissue disorder in a patient being treated for rheumatoid arthritis with the Janus kinase inhibitor tofacitinib.
Pilomatrical Carcinoma in a 70-Year-Old Hispanic Female
Authors: Harbold Jeffery S , Wagner Richard G , Lin Rick
Published: September 2020

Pilomatrical carcinoma is a rare, locally aggressive malignancy of follicular matrix origin. It presents as a rapidly growing, flesh-colored, or blueish, exophytic nodule with tumor asymmetry and poor circumscription. Histological features of these tumors include dominant hyperchromatic basaloid cells with high mitotic rate and nuclear pleomorphism; along with anucleate matrical cells and central necrosis. Pilomatrical carcinomas demonstrate a high rate of recurrence and tendency to metastasize. The most described treatment is wide excision of the tumor with negative margins with or without adjuvant radiation therapy. We present the case of a 70-year-old female patient who presented to the office with a 3-year history of a growing, exophytic lesion on the right nasal ala. A biopsy of the lesion was obtained, and histologic examination was consistent with a diagnosis of pilomatrical carcinoma.
A Rare Case of Angiolymphoid Hyperplasia without Eosinophils, with Review of the Literature
Authors: Ko James , Nahmias Zachary P , Phelan Patrick S , Abner Sabra , Blackwell Kara , Schaffer Andras
Published: September 2020

The epithelioid hemangioma, more commonly termed angiolymphoid hyperplasia with eosinophils, is a pathologic vascular proliferation characterized by a distinctive eosinophil-rich mixed inflammatory infiltrate. A nonspecific accompanying infiltrate has only rarely been reported, and may confound the diagnosis of this benign process with malignant mimics. We present such a case of angiolymphoid hyperplasia without eosinophils, and consider its diagnosis and pathogenesis within the spectrum of related entities.
Facial Papules in Birt-Hogg-Dubé Syndrome: A Growing Spectrum of Pathologic Findings
Authors: Yi Lauren G , Guerra Ricardo , Wu Sam B , Flowers Richard H
Published: September 2020

Birt-Hogg-Dubé syndrome is rare genodermatosis caused by a mutation in the folliculin gene. It is characterized by pulmonary cysts, renal tumors, and a variety of skin manifestations including trichodiscomas, fibrofolliculomas, less commonly reported angiofibromas, and perifollicular fibromas.  These cutaneous lesions have overlapping histopathologic features. Here we report a case of a man presenting with facial papules and nonspecific histology found to have Birt-Hogg-Dubé syndrome and a novel mutation in the folliculin gene. Our aim is to raise awareness of the spectrum of associated cutaneous and pathologic findings in Birt-Hogg-Dubé syndrome, which are not all included in the diagnostic criteria.
Pruritic Papulonodules Following Tattoo Application
Authors: Sarriera-Lazaro Carlos J , Safai Bijan
Published: September 2020

Abstract not available.
Autosensitization due to Pediculosis Capitis (a “Pediculid”) in a 16-Year Old Female: A Case Report
Authors: Kolb Logan , Hignett Emma , Kwong Pearl
Published: September 2020

Abstract not available.
Dermatologists' Perceptions and Use of Electronic Health Record Systems
Authors: Katamanin Olivia , Glazer MD Alex M
Published: September 2020

Introduction: Electronic Health Records (EHR) have been adopted and integrated into medical practices over the past 20 years. Many positive and negative implications have been described by physicians using EHR. This study aims to US dermatologists' perceptions and use of EHR within their clinical practice.
Methods: A validated survey was administered to US dermatologists at a national educational conference to assess use and perceptions of EHR.
Results Seventy-two percent (291/400) of those sampled completed greater than 90% survey and were included in outcome analysis. Eighty-six percent of the participants were currently using or had used EHR. Most dermatologists felt that EHR negatively impacted their workflow efficiency and face-to-face time with patients. A portion of dermatologists thought that EHR improved their documentation.
Limitations: Selection bias may have led those with strong beliefs with EHR more likely to complete the entire survey.
Conclusion: Despite widespread adoption, most dermatologists have a negative impression of EHR and felt that it interfered with their ability to effectively see patients. Interventions to improve EHR should focus on improving workflow efficiency and maximizing the amount of time dermatologists can spend with patients.
Delusions of Parasitosis Influenced by Crowdsourcing Diagnostic Platform CrowdMed
Authors: Stashower Julian , Belote Katherine , Zlotoff Barrett
Published: September 2020

Thousands of patients look to crowdsourcing websites such as CrowdMed for medical guidance. These websites can provide opportunities for patient education and facilitate the spread of knowledge. However, when used inappropriately, crowdsourcing websites like CrowdMed can put strain on doctor-patient relationships. We present a case that highlights how a patient’s delusions of parasitosis were influenced and supported by the crowdsourcing website CrowdMed.
Plant Fiber Contaminants in Morgellons Disease Skin Samples
Authors: Middelveen Marianne J , Stricker Raphael B
Published: September 2020

Abstract not available.
Letter to the Editor: Commentary on “Avoiding the Hazards of Ultraviolet Light in the Adolescent Population”
Authors: Weisert Elise M , Hinds III Ethan D
Published: September 2020

Abstract not available.
Commentary in Response: Commentary on “Avoiding the Hazards of Ultraviolet Light in the Adolescent Population”
Authors: Auchus Alexander , Brodell Robert T , Nahar Vinayak K , Ward Kimberley HM
Published: September 2020

Abstract not available.
Norman Orentreich: Father of Hair Modern Transplantation
Authors: Phan Michael , Phan Jonathan
Published: September 2020

Abstract not available.
Integrating Electrical Impedance Spectroscopy into Clinical Decisions for Pigmented Skin Lesions Improves Diagnostic Accuracy: A Multitiered Study
Authors: Litchman Graham H , Marson Justin W , Svoboda Ryan M , Rigel Darrel S
Published: September 2020

Introduction: The number-needed-to-biopsy (NNB) metric measures the efficiency of a clinician’s ability to accurately diagnose and recommend pigmented skin lesions (PSLs) for biopsy for suspected melanomas. Electrical impedance spectroscopy (EIS) is a non-invasive technique that measures differences in resistance between healthy and cancerous skin cells, intended as an aid to enhance diagnostic accuracy.Methods: Dermatology clinicians of three distinct groups (residents, physician assistants/nurse practitioners, and practicing dermatologists) were evaluated on their ability to accurately recommend suspect PSLs for biopsy before and after the integration of EIS data.Results: All three groups had a reduction in NNB after the inclusion of EIS. Instances of missed biopsies for malignant melanoma were significantly reduced with simultaneous significant reductions in unnecessary biopsies for benign lesions. There was a material improvement of biopsy selection for PSLs having clinically challenging features. EIS also greatly improved the diagnostic acumen of clinicians whose assessments were less accurate than their peers prior to EIS incorporation.Conclusions: The integration of EIS technology into the PSL biopsy decision was demonstrated to be effective in significantly enhancing clinician NNB and more accurate PSL biopsy selection.
Sentinel Lymph Node Predictors in Melanoma of Breslow Thickness 0.8-1.0 mm
Authors: Christensen Luisa Fernanda , Carr David , Hill Sheena , Ramser Elizabeth , Perez Jaime Abraham , Bordeaux Jeremy
Published: September 2020

Introduction: Current melanoma staging guidelines consider all patients staged T1b to have the same metastatic risk and recommends that sentinel lymph node biopsy (SLNB) be considered in this disparate group. The goals of this study were to specifically determine predictors of sentinel lymph node positivity and those predictive for obtaining a SLNB in melanomas of Breslow thickness 0.8 mm to 1.0 mm, which has not been previously studied.Methods: Retrospective review between January 1997 and July 2019 of patients with melanomas between 0.8 mm-1.0 mm in thickness. Patient demographics and primary tumor characteristics were correlated with SLN status.Results: Of the 458 patients found to meet Breslow thickness criteria, 223 (61.8%) underwent SLNB. Multivariate analyses demonstrated that < 60 years of age (OR 2.42), increasing Breslow thickness (OR 1.27), mitotic rate >1 (OR 2.32) and presence of tumor infiltrating lymphocytes (OR 3.33), were associated with performing a SLNB. Positive SLNB was found in 20 (8.1 %). Univariate analyses revealed females (p=0.016) to have an increased risk for positive SLNB.Limitations: Limited number of positive SLN and survival data available.Conclusions: Younger age, Breslow thickness ≥0.9 mm, mitotic rate >1, and presence of tumor infiltrative lymphocytes were found to be factors predictive of performing SLNB. Female gender significantly increased the odds of a positive SLN.
Chilblains-Like Lesions as a Presenting Manifestation of COVID-19
Authors: Comeau Victoria , Goodman Marcus , Julian Carmen , Ceci Francesca M
Published: September 2020

Dermatologic manifestations associated with coronavirus disease 2019 (COVID-19) remain broad and nonspecific. While a surge of “COVID toes” have been reported worldwide, very few cases have been documented in reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed COVID-19 patients. Furthermore, majority of confirmed COVID-19 patients with chilblains-like lesions presented with cutaneous lesions localized to the toes, which was preceded by other systemic symptoms. Our case report describes an occurrence of chilblains-like lesions, limited to the fingers, in an asymptomatic COVID-19 patient confirmed by RT-PCR.
Cetuximab Induced Hidrocystomas: A Case Report
Authors: Nagrani Nicole , Castillo David E , Miteva Mariya , Nichols Anna
Published: September 2020

Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor that commonly results in follicular-based acneiform eruptions. EGFR is expressed in the epidermis, hair follicle epithelium, sweat gland apparatus, and plays an important role in the differentiation and development of the hair follicle. In this report we describe a 70-year-old man who developed an acneiform eruption on his nose, cheeks, neck, and back when cetuximab was started for metastatic colorectal carcinoma.  This initial eruption improved with cessation of cetuximab but left residual cystic papules on his nose and multiple superficial white cysts on his bilateral cheeks, neck and back. Skin biopsy of a representative lesion on the nose revealed a cyst-like cavity lined with epithelium similar to sweat glands within the dermis consistent with a hidrocystoma. In this case, it is plausible that the use of an EGFR inhibitor resulted in a cutaneous inflammatory reaction, that subsequently healed with blockage of the sweat duct apparatus causing the formation of cutaneous cysts, including both hidrocystomas and milia. Alternatively, the blockage of the duct may have resulted from inhibition of basal cell migration and increased cell adhesion within the eccrine gland causing accumulation of eccrine gland secretion, and eventually hidrocystomas. To our knowledge, this is the first case describing the resolution of a typical cetuximab-induced acneiform eruption with residual hidrocystomas and milia.
BMS-986165, an Oral, Selective TYK2 Inhibitor, in the Treatment of Moderate to Severe Psoriasis as Assessed by the Static Physician's Global Assessment (sPGA)/Body Surface Area (BSA) Composite Tool (sPGAxBSA), a Clinically Useful Alternative to PASI
Authors: Gottlieb Alice B , Strober Bruce , Thaçi Diamant , Gordon Kenneth , Kundu Sundeep , Kisa Renata , Wei Lan , Banerjee Subhashis , Merola Joseph
Published: September 2020

Abstract not available.
Safety of Long-Term Proactive Management with Fixed-Dose Combination Calcipotriene 0.005% and Betamethasone Dipropionate 0.064% Foam in Patients with Psoriasis Vulgaris: Results of a Phase III, Multicentre, Randomized, 52-Week, Vehicle-Controlled Trial
Authors: Lebwohl Mark , Lacour Jean-Philippe , Liljedahl Monika , Lynde Charles , Mørch Marie H , Thaçi Diamant , Warren Richard B
Published: September 2020

Abstract not available.
Combination of Calcipotriene 0.005% Foam and Halobetasol Propionate 0.05% Foam in the Treatment of Scalp Psoriasis
Authors: Young Alexis , Schreiber Rhonda
Published: September 2020

Abstract not available.
Efficacy and Safety of Long-Term Tildrakizumab for Plaque Psoriasis: 4-Year Results from Resurface 1 and Resurface 2
Authors: Langley Richard G , Crowley Jeffrey , Gooderham Melinda , Papp Kim A , Korman Neil J , Spelman Lynda , Igarashi Atsuyuki , Ohtsuki Mamitaro , Gupta Aditya K , Yamauchi Paul , Parno Jeffrey , Mendelsohn Alan M , Rozzo Stephen J , Eads Kimberly
Published: September 2020

Abstract not available.
Efficacy and Safety of Tildrakizumab 100 Mg for Plaque Psoriasis in Patients Randomized to Treatment Continuation vs Treatment Withdrawal with Retreatment upon Relapse in Resurface 1
Authors: Cantrell Wendy , Lee Patricia , Mendelsohn Alan M , Parno Jeff , Rozzo Stephen J , Liao Wilson
Published: September 2020

Abstract not available.
Certolizumab Pegol for Treatment of Plaque Psoriasis: Pooled Three-Year Efficacy Outcomes from Two Phase 3 Trials (CIMPASI-1 and CIMPASI-2)
Authors: Gordon K , Warren R B , Gottlieb A B , Blauvelt A , Thaçi D , Leonardi C , Poulin Y , Boehnlein M , Kavanagh S , Arendt C , Reich K
Published: September 2020

Abstract not available.
Durable Efficacy of Certolizumab Pegol Dosed at 400 mg Every Two Weeks Over 128 Weeks in Patients with Plaque Psoriasis Enrolled in Three Phase 3 Trials (CIMPASI-1, CIMPASI-2 and CIMPACT)
Authors: Gordon K , Warren R B , Gottlieb A B , Blauvelt A , Thaçi D , Poulin Y , Boehnlein M , Brock F , Arendt C , Reich K
Published: September 2020

Abstract not available.
Long-Term Safety of Certolizumab Pegol in Plaque Psoriasis: Pooled Analysis over 3 Years from Three Phase 3, Randomized, Placebo-Controlled Studies
Authors: Blauvelt A , Paul C , Van de Kerkhof P , Warren R B , Gottlieb A B , Langley R G , Brock F , Arendt C , Boehnlein M , Lebwohl M , Reich K
Published: September 2020

Abstract not available.
Dupilumab Improves Symptoms of Anxiety and Depression in Adults and Adolescents With Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of Three Phase 3 Trials (LIBERTY AD SOLO 1 and 2 and ADOL)
Authors: Silverberg Jonathan I , Soong Weily , Lockshin Benjamin , Gadkari Abhijit , Chen Zhen , Bansal Ashish
Published: September 2020

Abstract not available.
Long-Term Effect of Dupilumab With Concomitant Topical Corticosteroids on POEM in Adults With Moderate-to-Severe Atopic Dermatitis: LIBERTY AD CHRONOS Trial
Authors: Silverberg Jonathan I , Lockshin Benjamin , Gooderham Melinda , Chen Zhen , Gadkan Abhijit , Rossi Ana B
Published: September 2020

Abstract not available.
Safety and Tolerability of Sarecycline for the Treatment of Acne Vulgaris
Authors: Pariser David M , Green Lawrence J , Lain Edward L , Schmitz Carsten , Chinigo Amy S , McNames Brian , Berk David R , Hoffman Jamison , Grada Ayman
Published: September 2020

Abstract not available.
Open-Label Extension Study Evaluating the Long-Term Safety, Efficacy, and Tolerability of FMX103 1.5% Topical Minocycline Foam in the Treatment of Moderate-to-Severe Facial Papulopustular Rosacea
Authors: Gold Linda Stein , Del Rosso James Q , Kircik Leon , Bhatia Neal D , Hooper Deirdre , Nahm Walter , Stuart Iain
Published: September 2020

Abstract Not Available.
Effect of Combination Therapy on Visible/Non-Visible Symptoms, and Disease Burden Associated with Severe Rosacea: Results from A Post-Hoc Analysis of A Randomized Controlled Trial
Authors: Del Rosso James Q , Jackson Mark , Johnson Sandra , Harvey Alison , Chavda Rajeev
Published: September 2020

Abstract not available.
Trifarotene 50 µg/G Cream for Treatment of Acne Vulgaris – A Summary of Two Randomized Trials and a Long-Term Safety Study
Authors: Tan Jerry , Del Rosso James , Weiss Jonathan , Gold Linda Stein , Cook-Bolden Fran , Eichenfeld Lawrence , Tanghetti Emil , Saenz Alessandra Alió , Ahmad Faiz
Published: September 2020

Abstract not available.
Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability
Authors: Gold Linda Stein , Pariser David M , Levy Marci , Guenin Eric
Published: September 2020

Abstract not available.
Safety, Pharmacokinetics, and Efficacy of Efinaconazole 10% Topical Solution for the Treatment of Onychomycosis in Pediatric Patients
Authors: Eichenfield Lawrence F , Elewski Boni , Sugarman Jeffrey L , Rosen Ted , Gupta Aditya , Cantrell Wendy , Pillai Radhakrishnan , Jacobson Abby
Published: September 2020

Abstract not available.
Tirbanibulin Ointment 1%, a Novel Inhibitor of Tubulin Polymerization and Src Kinase Signaling , for the Treatment of Actinic Keratosis (AK): Results from Two Pivotal Phase III Studies
Authors: Blauvelt Andrew , Kempers Steven , Forman Seth , Lain Edward , Bruce Suzanne
Published: September 2020

Abstract not available.
Impact of a Prognostic 40-Gene Expression Profiling Test on Clinical Management Decisions for High-Risk Cutaneous Squamous Cell Carcinoma
Authors: Litchman Graham H , Fitzgerald Alison L , Kurley Sarah J , Cook Robert W , Rigel Darrell S
Published: September 2020

Abstract not available.
Evaluation of Different Approaches in Managing Local Skin Reactions With the Use of Ingenol Mebutate 0.015% and 0.05% During the Treatment of Actinic Keratosis
Authors: Freeman Scott , Bettencourt Miriam , Corliss Meg , Dunkelly-Allen Nikeshia , Veverka Karen A
Published: September 2020

Abstract not available.
Adverse Events of Special Interest in Patients with Advanced Basal Cell Carcinoma Receiving Sonidegib: Long-Term 42-Month Results from the BOLT Study
Authors: Guminski Alexander , Squittieri Nicholas , Lear John T
Published: September 2020

Abstract not available.
Duration of Response and Progression-Free Survival with Sonidegib 200 Mg Once Daily Until Disease Progression or Start of New Antineoplastic Therapy in Patients with Locally Advanced Basal Cell Carcinoma: Results of the 42-Month, Randomized, Double-Blind
Authors: Migden Michael , Lear John , Squittieri Nicholas , Liu Li , Guminski Alexander , Dummer Reinhard
Published: September 2020

Abstract not available.
Effect of Concomitant Medications on Efficacy of Sonidegib 200 Mg Daily in Patients with Locally Advanced Basal Cell Carcinoma: Results of the 42-Month Randomized, Double-Blind BOLT Study
Authors: Dummer Richard , Migden Michael , Squittieri Nicholas , Liu Li , Guminski Alexander , Lear John
Published: September 2020

Abstract not available.
Reproducibility of a new classification of the anterior clinoid process of the sphenoid bone
Authors: Chaddad-Neto Feres , Costa Marcos Devanir Silva da , Santos Bruno , Caramanti Ricardo Lourenco , Costa Bruno Lourenco , Doria-Netto Hugo Leonardo , Figueiredo Eberval Gadelha
Published: September 2020

Background:

Pneumatization of the anterior clinoid process (ACP) affects paraclinoid region surgery, this anatomical variation occurs in 6.6–27.7% of individuals, making its preoperative recognition essential given the need for correction based on the anatomy of the pneumatized process. This study was conducted to evaluate the reproducibility of an optic strut-based ACP pneumatization classification by presenting radiological examinations to a group of surgeons.

Methods:

Thirty cranial computer tomography (CT) scans performed from 2013 to 2014 were selected for analysis by neurosurgery residents and neurosurgeons. The evaluators received Google Forms with questionnaires on each scan, DICOM files to be manipulated in the Horos software for multiplanar reconstruction, and a collection of slides demonstrating the steps for classifying each type of ACP pneumatization. Interobserver agreement was calculated by the Fleiss kappa test.

Results:

Thirty CT scans were analyzed by 37 evaluators, of whom 20 were neurosurgery residents and 17 were neurosurgeons. The overall reproducibility of the ACP pneumatization classification showed a Fleiss kappa index of 0.49 (95% confidence interval: 0.49–0.50). The interobserver agreement indices for the residents and neurosurgeons were 0.52 (0.51–0.53) and 0.49 (0.48–0.50), respectively, and the difference was statistically significant (P < 0.00001).

Conclusion:

The optic strut-based classification of ACP pneumatization showed acceptable concordance. Minor differences were observed in the agreement between the residents and neurosurgeons. These differences could be explained by the residents’ presumably higher familiarity with multiplanar reconstruction software.
Spontaneous improvement of secondary empty sella syndrome due to re-expansion of an intrasellar cyst: A case report
Authors: Yamada Shodai , Yagi Kenji , Hirano Kazuhiro , Uno Masaaki
Published: September 2020

Background:

In patients with secondary empty sella syndrome (ESS), optic nerve herniation into the sella turcica is caused by shrinkage of the mass lesion at the sella turcica, resulting in visual disturbance. ESS is often surgically treated using chiasmapexy. Here, we report the first case of spontaneous improvement in a patient with ESS.

Case Description:

A 69-year-old woman presented with a month-long history of visual disturbance in the right eye, poor visual acuity, and quadrantanopia in her upper temporal visual field. Magnetic resonance (MR) imaging showed herniation of her right optic nerve and gyrus rectus into the sella turcica. The visual disturbance gradually improved, and the patient’s vision became almost normal after a month without any treatment. On repeated MR imaging, it was observed that the herniation of the right optic nerve and gyrus rectus disappeared due to an intrasellar cyst re-expansion. The secondary ESS caused by the shrinkage of the intrasellar cyst resulted in the visual disturbance and re-expansion of the cyst resulted in spontaneous improvement of symptoms. The visual disturbance did not recur for a year.

Conclusion:

Patients with secondary ESS without severe symptoms may be followed up conservatively. However, surgical treatment should be applied if symptoms deteriorate or do not improve.
One-year follow-up for type II odontoid process fractures in octogenarians: Is there a place for surgical management?
Authors: Borsotti Francois , Starnoni Daniele , Ecker Timo , Coll Juan Barges
Published: September 2020

Background:

Type II odontoid fractures are becoming one of the most common injuries among elderly patients and are associated with increased morbidity rates. Here, we compared the safety/efficacy of conservative versus surgical treatment for type II C2 fractures and, in particular, evaluated the complications, hospital lengths of stay, and mortality rates for patients over 80 years of age.

Methods:

We retrospectively reviewed the records of 63 nonsurgically versus 18 surgically treated C2 fractures in patients over 80 years of age (2003–2018). Cervical computed tomography images, X-rays, and magnetic resonance images were reviewed by both a neurosurgeon and a neuroradiologist. The following patient data were included in the analysis; Glasgow Coma Scale score, injury severity score, the abbreviated injury scale scores, their comorbidities (e.g., utilizing the Charlson comorbidity index), their primary outcomes, and mortality rates (e.g., at 6 weeks and 1 year after treatment).

Results:

Eighty-one patients were included in the study; 63 were treated conservatively and 18 underwent surgical management of type II C2 fractures. Patients averaged 87.0 ± 5.0 years of age, and their combined mortality rates were 13.6% at 6 weeks and 25.9% at 1 year. Notably, at 1 year, the mortality rates were not statistically different between the two groups: 18 (30.0%) patients from the conservatively treated group versus 3 (16.7%) patients from the surgically managed patients died indicating (e.g., using the Kaplan–Meier analysis) no survival advantage for either treatment strategy.

Conclusion:

Surgical versus conservative management of type II odontoid fractures were associated with comparable high mortality rates at 1 year.
Profile of genetic variations in severely calcified carotid plaques by whole-exome sequencing
Authors: Katano Hiroyuki , Nishikawa Yusuke , Yamada Hiroshi , Iwata Takashi , Mase Mitsuhito
Published: September 2020

Background:

The precise mechanisms of carotid calcification and its clinical significance have not been established.

Methods:

We classified ten plaques from carotid endarterectomy patients into high- and low-calcified plaques based on the Agatston calcium scores. We performed whole-exome sequencing for genetic profiles with single nucleotide variations (SNVs), insertions, and deletions. Bioinformatic data mining was then conducted to disclose specific gene variations to either high- or low-calcified carotid plaques.

Results:

In the carotid plaques, G:C>A:T/C:G>T:A transitions as SNVs, insT after C/insC after A as insertions, and delA after G/delT after C as deletions were most frequently observed, but no significant difference was observed between the high- and low-calcified plaque groups in their proportion of base-pair substitution types. In the bioinformatic analysis, SNVs of ATP binding cassette subfamily C member 6 (ADCC6) were more commonly found in high-calcified plaques and SNVs of KLKB1 were more commonly found in low-calcified plaques compared to the other group. No new genetic variants related to calcification or atherosclerosis among those not registered in dbSNP was detected.

Conclusion:

Our findings clarified the features of base-pair substitutions in carotid plaques, showing no relation to calcification. However, genetic variants in ADCC6 relating to vascular calcification for high-calcified plaques, and in KLKB1 encoding kallikrein associated with vascular regulation of atherosclerosis for low-calcified plaques were more specifically extracted. These results contribute to a better understanding of the genetic basis of molecular activity and calcium formation in carotid plaques.
A rare case of spinal dural arteriovenous fistula mimicking malignant glioma of the medulla oblongata: Significance of cerebral angiography for accurate diagnosis of brain stem region
Authors: Shigekawa Seiji , Inoue Akihiro , Nakamura Yawara , Kohno Daisuke , Tagawa Masahiko , Kunieda Takeharu
Published: September 2020

Background:

The findings of a hyperintense sign on T2-weighted imaging (T2-WI) and gadolinium (Gd) contrast enhancement on magnetic resonance imaging (MRI) of the brain stem suggest malignant glioma. However, this pathological condition is probably uncommon, and it may be unknown that a dural arteriovenous fistula (DAVF) can imitate this radiological pattern. In addition, it is extremely rare to be caused by a spinal DAVF. Here, a rare case of spinal DAVF that mimicked malignant glioma of the medulla oblongata is presented.

Case Description:

A 56-year-old woman was admitted with a progressive gait disturbance, vertigo, and dysphasia. MRI showed a hyperintense signal in the medulla oblongata on fluid-attenuated inversion recovery (FLAIR) and moderate contrast enhancement on Gd-enhanced MRI. Interestingly, Gd-enhanced MRI demonstrated abnormal dilated veins around the brain stem and cervical spinal cord. Cerebral angiography showed spinal DAVF at the left C4/C5 vertebral foramen fed by the C5 radicular artery. The fistula drained into spinal perimedullary veins and flowed out retrograde at the cortical vein of the posterior cranial fossa. Therefore, surgical disconnection of the spinal DAVF was performed by a posterior approach. The patient’s postoperative course was uneventful. Cerebral angiography showed complete disappearance of the DAVF, with marked reductions of the hyperintense sign of the medulla oblongata on FLAIR.

Conclusion:

This important case illustrates MRI findings mimicking brain stem glioma. In cases with the hyperintense sign-on T2-WI associated with contrast enhancement suspicious of brainstem glioma, careful checking for perimedullary abnormal vessels and additional cerebral angiography should be performed.
Rare spondylodiscitis due to Mycobacterium mucogenicum
Authors: Furnari Massimo , Scalia Gianluca , Umana Giuseppe Emmanuele , Giuffrida Massimiliano , Ponzo Giancarlo , Garozzo Sebastiano Fabio , Nicoletti Giovanni Federico
Published: September 2020

Background:

Nontuberculous mycobacteria (NTM) represents an important cause of infection, particularly in immunocompromised patients. Spondylodiscitis is unusual and may be associated with underlying causes such as drug abuse. Timely diagnosis and treatment are critical, as without this, patients will demonstrate progressive neurological deterioration. Here, we present a rare case of Mycobacterium mucogenicum spondylodiscitis in a 36-year-old male, along with a focused literature review.

Case Description:

A 36-year-old female with previous drug abuse presented with 3-years of progressive thoracolumbar pain. The MRI of the spine revealed paravertebral abscesses from Th10–L1 with vertebral lesions involving Th11–Th12 levels (e.g., vertebral body collapse/deformity and destruction of the posterior vertebral walls). After a needle CT-guided biopsy of the paravertebral tissues, real time-polymerase chain reaction (RT-PCR) amplification documented NTM; the final identification was M. mucogenicum. The patient then underwent a Th11–Th12 decompressive laminectomy, facetectomy, granulomatous tissue debridement, and posterior pedicle screw fusion from Th8–Th10, and L1–L3. Postoperatively, the patient’s pain resolved, and she was left with residual lower extremities dysesthesias; 6-months later, she could walk without assistance.

Conclusion:

Spondylodiscitis caused by M. mucogenicum is rare, and the medical and surgical treatment is comparable to that for other NTM groups.
Coexisting arachnoid cyst and tentorial sinus: A therapeutic dilemma
Authors: Ferrigno Ana S. , Figueroa-Sanchez Jose A.
Published: September 2020

A 4-year-old male presented with a large arachnoid cyst over the left temporal region causing displacement of adjacent structures. Cerebral angiography showed dilatation of the tentorial sinus without other apparent vascular alterations. The association of these two anomalies raises a therapeutic dilemma as no information is available about how the variants of the venous system can modify cerebrospinal fluid hydrodynamics and thus affect arachnoid cyst’s prognosis. In this case, the patient was treated conservatively and has remained stable for 2 years.
Hubungan Simultan Bank-Firm Relationship dan Kinerja pada Perusahaan Socially Responsible Investment (SRI) di Indonesia
Authors: Zusryn Alyta Shabrina , Innayah Maulida Nurul , Sahulata Hanastasya
Published: September 2020

A bank-firm relationship in the company occurs when the bank as a lender can obtain more extensive information from other parties. This study aims to examine the simultaneous relationship between bank-firm relationships and company performance. The sample in this study is non-financial socially responsible investment (SRI) firms listed on the SRI KEHATI index. The data analysis method uses two-stage least square (2SLS). The results of this study found that only multiple-bank relationships had a positive and significant effect on company performance. In addition, the company's performance also influences the company's decision to conduct multiple-bank relationships. These results indicate a simultaneous relationship between multiple-bank relationships and the performance of companies that implement socially responsible investment (SRI) in Indonesia. Multiple-bank relationships provide convenience to banks in monitoring companies. While other indicator such as company relations with foreign banks, domestic banks, the number of banks and the bank loan ratio (BLR) were not significant in the simultaneous relationship. The implication of this research is that a company can conduct multiple-bank relationships to diversify external funding sources, reduce credit constraints and reduce strategy failures.
Determinant of Tax Aggressiveness and Relationship with Firm Value (Empirical Study Company Listed Go-Public in Indonesia Stock Exchange)
Authors: Hitten Akhmad , Novita Novita
Published: September 2020

This study aims to determine the effect of liquidity, profitability, and solvability on the level of tax aggressiveness with firm value as a control variable. Total sample was 86 non-financial company that implicate tax aggressiveness in Indonesia Stock Exchange (IDX), with purposive sampling, with cross section data period 2007 to 2017. This study using agency theory and signaling theory as the grand theory. The data were analyzed using Structural Equation Modeling- Partial Least Square (SEM-PLS). This study uses a SmartPLS 3.0 and must pass outer and inner criteria. The reason why the author choose SmartPLS is because this application program can explain each indicator of the variable, so will be easy to evaluate which indicator that not have the correspondent affect with the dependend variable. The previous studies of ETR showed inconsistent results in various countries. Test results show that liquidity and profitability have a negative and significant influenced with tax aggressiveness. Solvability has a negative and not significant influenced on tax aggressiveness. Firm value has a positive and significant influenced on tax aggressiveness.
Misprice, Leverage and Stock Buyback: Evidence in Indonesia
Authors: Lailiyah Elliv Hidayatul , Purwanti Ika , Sulton Muhammad
Published: September 2020

Cash distribution by stock buyback is one ways to increase stockholder wealth. This study is to analyze the effect of misprice (misvaluation) and leverage on stock buyback. Limited prior study discussed about stock buyback and misprice especially in Indonesia, theoritically, in Indonesia not only firm with undervalue stock do stock buyback but also firm with overvalue stock. Stock buyback can increase the stock prices, but the implementation in Indonesia is still small. Non-financial firms listed on the Indonesia Stock Exchange from 2010 to 2017 used in this study. Samples were taken by a purposive sampling method based on certain criteria. The data analysis techniques use multiple linear regression statistical analysis. The results showed that misprice has a positive effect on buyback. The different thing found in Indonesia because overvalued firms hold stock buyback. Leverage has a negative effect on stock buyback. Firms with leverage below the target tend to do a stock buyback. In addition, the stock buyback also used to correct prices (for undervalued stock to be fair). The implication in this study is stock buyback not only viewing to correct prices but also giving a signal to the market that the firm is in a good fundamental condition.
Pengaruh Tipe Kepemilikan Ultima Keluarga dan Negara Terhadap Risiko Likuiditas Bank
Authors: Fadli Jul Aidil , Sakti Imanuel Madea
Published: September 2020

This research aims to examine the effects of family and state bank ownership on bank liquidity risk. The 20% ownership threshold determines the type of ownership, and the robustness test determined by the 25% ownership threshold, then bank liquidity risk is measured by Loan to Deposit Ratio (LDR). This study also used bank size to measure total bank assets, dummy listed or non-listed banks on the Indonesia Stock Exchange, and Capital Adequacy Ratio (CAR) as a measure of bank capital. The data used in this research are panel data of 59 commercial banks operated in Indonesia since 2010 to 2016. Using multiple linear regression analysis with Generalized Least Square estimation, the result shows that banks owned by family or state have lower liquidity risk than banks that do not belong to family or state. This research can be a reference for The Financial Services Authority and Indonesia Deposit Insurance Corporation to establish strategies and regulations related to bank liquidity risk.
Corporate governance in sustainability indexes: a Spanish case study
Authors: Andreu-Pinillos Alberto , Fernández-Fernández José-Luis , Fernández-Mateo Joaquín
Published: September 2020

In recent years, corporate governance and corporate social responsibility have come closer in academic research, and especially on sustainability indexes. In fact, the most significant indexes handle the matter of corporate governance along with other environmental and social criteria. The purpose of this study is to find out if all the variables included in the corporate governance dimension on the above mentioned indicators are equally relevant and material for both corporate social responsability and corporate governance. To carry out the study, a sample of academics and professionals from Spanish universities and businesses sector was taken. We defend the plausible hypothesis that not all items included within corporate governance dimension on sustainability indexes are homogeneous and interchangeable and, therefore, equally relevant. As a result, the measurements provided by these indexes may not be truly representative.
Los openings, antesala del relato de ficción en televisión: identidad y marca
Authors: Magro-Vela Silvia , Puebla-Martínez Belén , Baraybar Fernández Antonio
Published: September 2020

Los openings han sufrido un proceso de transformación hasta convertirse en parte integrante e integradora del relato ficcional. Se presenta el estudio de las cabeceras de Isabel, Víctor Ros y El Ministerio del tiempo, de Javier Olivares, llevado a cabo desde 4 ejes: análisis de aspectos formales, narrativos, tipográficos y sonoros. Mediante los rasgos comunes y disímiles compartidos con los títulos de crédito cinematográficos se pretende comprobar la relación que guardan con el proceso de construcción de identidad y marca del producto audiovisual como unidad independiente de su creador.