bluuebunny/crossref_metadata_2025 huggingface dataset:
Multidecadal, Continent-level Analysis Found No Impact of Climate Warming on Wheat Aphids
Authors: Sun Xiao , Sun Yumei , Ma Ling , Liu Zhen , Wang Qiyun , Wang Dingli , Zhang Chujun , Yu Hongwei , Xu Ming , Ding Jianqing , Siemann Evan
Published: December 2021

Temperature drastically determines insect abundances, thus under climate change, identifying major drivers affecting pest insect populations is critical to world food security and agricultural ecosystem health. Here, we conducted a meta-analysis with data obtained from 120 studies across China and Europe from 1970 to 2017 to reveal the roles of climate and agricultural practices in determining populations of wheat aphids. We showed aphid loads on wheat had distinct patterns between these two regions, with a significant increase in China but decrease in Europe over this time period. Although average winter and growing season temperatures increased over this period in both regions, we found no evidence showing climate warming affected aphid loads. Rather, differences in pesticide use, fertilization, land use, and natural enemies between China and Europe may be key factors accounting for differences in aphid pest populations. These findings provide insights for developing effective agroecosystem management under global change. These long-term data suggest that climate change may not be the most important driver of agricultural pest loads. Therefore, under global environmental change, consideration of multiple factors at large spatial-temporal scales will likely provide more insights for developing effective agroecosystem management to safeguard world food security.
Erythrocyte Membrane-Enveloped Molybdenum Disulfide Nanodots for Biofilm Elimination on Implants Via Toxin Neutralization and Immune Modulation
Authors: Shi Tingwang , Ruan Zesong , Wu Jianrong , Zou Weijuan , Cai Xiaojun , Zheng Yuanyi , Chen Yunfeng
Published: December 2021

Backgrounds:
Implant-related infections (IRIs) caused by bacterial biofilms remain a prevalent but tricky clinical issue, which are characterized by drug resistance, toxin impairment and immunity suppression. Recently, antimicrobial therapies based on reactive oxygen species (ROS) or hyperthermia have been developed to effectively destroy biofilms. However, all of them have failed to simultaneously focus on the immunosuppressive microenvironment of biofilms and tissue damage caused by bacterial toxins.
Results
Herein, we proposed a one-arrow-three-hawks strategy to orchestrate hyperthermia/ROS antibiofilm therapy, toxin neutralization and immunomodulatory therapies through engineering a bioinspired erythrocyte membrane-enveloped molybdenum disulfide nanodots (EM@MoS2) nanoplatform. In biofilm microenvironment, pore-forming toxins actively attack the erythrocyte membranes on the nanodots and be detained, thus keeping toxins away from their targets and mitigating tissue damage. Under near-infrared laser irradiation, MoS2 nanodots, with superb photothermal and peroxidase-like properties, exert a powerful synergistic antibiofilm effect. More intriguingly, we initially identified that they possess the ability to reverse the immunosuppressive microenvironment through skewing the macrophages from an anti-inflammatory phenotype to a proinflammatory phenotype, which would promote the elimination of biofilm debris and prevention of infection relapse. Systematic in vitro and in vivo evaluations have demonstrated that EM@MoS2 achieves remarkable antibiofilm effect.
Conclusion
The current study integrated the functions of hyperthermia/ROS therapy, virulence clearance and immune regulation, which could provide an effective paradigm for IRIs therapy.
Alkali Can Accelerate The Cellulose Dissolution In Aqueous 1-Ethyl-3-Methylimidazole Acetate (EmimAc/10% Water)
Authors: Ni Liufang , Lu Xingmei , Yu Jing , Lin Changmei , Cao Xiaoxia , Cao Shilin , Ma Xiaojuan , Gao Haili
Published: December 2021

Ionic liquids are potential and successful cellulose solvent but still suffer technical and economic issues in the cellulose commercialization. In this work, a relative low-viscosity aqueous 1-ethyl-3-methylimidazole acetate (EmimAc with 10% water) was used instead of EmimAc to dissolve cellulose; the results showed that adding NaOH to water can significantly accelerate cellulose dissolution and the cellulose solubility increased with the NaOH concentration in the EmimAc/10% water solution. NaOH can weaken the strong interaction between water and EmimAc because it can bond preferentially with water by hydrogen bonding and therefore release Ac - from Ac - -water cluster; which can enhance the reaction between Emim + and Ac - and therefore improve the cellulose dissolution. Unfortunately, the NaOH introduction inevitably cause a cellulose degradation via peeling reaction.
High-Throughput Growth of HfO2 Films Using Temperature-gradient Laser Chemical Vapor Deposition
Authors: TU Rong , LIU Ziming , WANG Chongjie , LU Pengjian , GUO Bingjian , XU Qingfang , LI Bao-Wen , WANG Chuanbin , ZHANG Lianmeng , Zhang Song
Published: December 2021

The use of hafnia (HfO2) has facilitated recent advances in combining uprated dielectric layers (UDLs) and environmental barriers (EBs) in supercomputers. However, an extremely low deposition rate limits further development and fabrication efficiency of HfO2 films. In this study, high-throughput growth of HfO2 films was realized via laser chemical vapor deposition using a laser spot with a gradient temperature distribution. In HfO2 films fabricated by a single growth process, four regions with different morphologies could be discerned for deposition temperatures increasing from 1300 K to 1600 K: leaf-like, pyramid-like, bromeliad-like and pinecone-like. Two growth modes were observed for Regions I and II: Stranski-Krastanov and Volmer-Weber. Regions III and IV contained coexisting monoclinic and tetragonal HfO2 grains with an in-plane boundary for m-HfO2 (-110) {111}//t-HfO2 (1-11) {111}. The maximum deposition rate reached 362 μm/h, which was 102 - 104 times higher than that obtained using existing deposition methods.
Reading and Writing The Combined Effects of Regular Classroom and Remedial Learning Programs on the Reading Achievement of First Grade Pupils
Authors: Steve Bissonnette , Boyer Christian , Morneau-Guérin Frédéric
Published: December 2021

In 2003, two school-based programs for teaching reading in English were introduced in Québec: the Accelerated Development of Reading (ADOR) program for first graders and, for ADOR pupils with weak reading skills, the Intensive Intervention in Reading (IIR) support program. Explicit and direct instruction provides the framework for ADOR and IIR. Two quasi-experimental studies were conducted to measure the effects of the ADOR and IIR programs compared to regular reading instruction and remediation. In both studies, the combined effects of ADOR and IIR were measured on two separate cohorts of grade 1 pupils over a full school year. This study shows that the ADOR and IIR programs result in superior reading performance and the largest effects were on subtests measuring reading comprehension.
Histological and Top-Down Proteomic Analyses of the Visual Pathway Using the Cuprizone Demyelination Model
Authors: Almuslehi Mohammed S. M. , Sen Monokesh K. , Shortland Peter J. , Mahns David A. , Coorssen Jens R.
Published: December 2021

A change in visual perception is a frequent early symptom of multiple sclerosis (MS), the pathoetiology of which remains unclear. Following a slow demyelination process caused by 12 weeks of low-dose (0.1%) cuprizone (CPZ) consumption, histology and proteomics were used to investigate components of the visual pathway in young adult mice. Histological investigation did not identify demyelination or gliosis in the optic tracts, pretectal nuclei, superior colliculi, lateral geniculate nuclei or visual cortices. However, top-down proteomic assessment of the optic nerve/tract revealed a significant change in the abundance of 34 spots in high-resolution 2D gels. Subsequent liquid chromatography-tandem mass spectrometry analysis identified alterations in 75 proteoforms. Literature mining revealed the relevance of these proteoforms in terms of proteins previously implicated in animal models and human MS. Importantly, 24 proteoforms were not previously described in any animal models of MS or MS itself. Bioinformatic analysis indicated involvement of these proteoforms in cytoskeleton organization, metabolic dysregulation, protein aggregation, and axonal support. Collectively, these results indicate that continuous CPZ-feeding, which evokes a slow demyelination, results in proteomic changes that precede any clear histological changes in the visual pathway and that these proteoforms may be potential early markers of degenerative demyelinating conditions.
Dynamics Study of Constant DI and Constant TR Control for Cardiac Alternans Based on a Two Dimensional Cellular Automata Model
Authors: Xiong Min , Sun Kai , Su Xiaowen , Tolkacheva Elena G. , Zhao Xiaopeng
Published: December 2021

As a precursor for cardiac arrhythmias such as atrial and ventricular fibrillations, which could cause sudden cardiac death (SCD), cardiac alternans is essentially an unstable heart rhythm with alternating long and short action potential durations (APD) of cardiac myocytes that usually occurs under fast pacing conditions. In this paper, the constant TR control method based on global pseudo-electrocardiogram (ECG) is studied and compared with the local constant diastolic interval (DI) control method using a 2-dimensional (2-D) cellular automata model (CAM), aiming at preventing or eliminating cardiac alternans before arrhythmias. The results show that both the constant TR and constant DI control methods are effective in stabling the alternans to a smaller basic cycle length (BCL). Also, the efficacy of the two control approaches depends on the “decrease step” Δ in the downsweep protocol, and a smaller Δ could significantly improve their performance. Besides, in general, constant TR control is superior to constant DI control in alternans prevention when a relatively large Δ is adopted.
The Threshold of Visceral Adipose Tissue Areas Measured With QCT On Cardiometabolic Risk Factors In A Nationwide Study In China
Authors: Zha Xiaojuan , Lu Yanhui , Li Yongli , Yan Dong , Ran Limei , Lu Yong , Yang Yingying , Liu Yandong , Zhao Kaiping , Glen Blake M. , Zou Mingzhu , Cheng Xiaoguang , Chen Min
Published: December 2021

Background: Abdominal adiposity is associated with increased cardiometabolic risk and visceral adipose tissue (VAT) area obtained from computed tomography (CT) is a key anthropometric index. The present study investigated the VAT criteria on cardiometabolic risk factors in a large-scale nationwide Chinese population.Method: A total of 21,772 adults who underwent a low dose chest CT (LDCT) for lung cancer screening at one of 13 health checkup centers throughout China and had complete ancillary health records were evaluated. Abdominal VAT area at the center of L2 vertebra was measured with Mindways quantitative CT software using the existing LDCT dataset. Relevant anthropometric, serum and blood pressure measurements were obtained from the participants’ records. The VAT distribution of the LDCT cohort was age-adjusted using the Chinese national census. Results: The prevalence of metabolic syndrome based on the Chinese national guidelines was 29.5% and 10.5% in men and women respectively. Using ROC curves, the optimum threshold values for VAT area to identify metabolic syndrome were 213 cm2 in men, and 136 cm2 in women. For participants with VAT area above threshold, the odds ratio (95% confidence interval) for metabolic syndrome was 6.15 (5.65, 6.69) and 9.25 (7.58, 11.4) for men and women respectively. A further analysis of population attributable risk showed that VAT above threshold was significantly associated with an increased risk for metabolic syndrome.Conclusion: In this large-scale nationwide population of China, sex-specific threshold values for VAT area measured by CT were established to identify the risk of metabolic syndrome. VAT area is a key anthropometric index of interventions to control cardiometabolic risk.
Neutralising reactivity against SARS-CoV-2 B.1.617.2 (Delta) variant by vaccination status and pre-exposure
Authors: Lavezzo Enrico , Pacenti Monia , Manuto Laura , Boldrin Caterina , Cattai Margherita , Grazioli Marco , Bianca Federico , Sartori Margherita , Caldart Federico , Castelli Gioele , Nicoletti Michele , Nieddu Eleonora , Salvadoretti Elisa , Labella Beatrice , Fava Ludovico , Vanuzzo Maria , Lisi Vittoria , Antonello Maria , Grimaldi Carmela , Zulian Chiara , Vecchio Claudia Del , Plebani Mario , Padoan Andrea , Cirillo Daniela Maria , Brazzale Alessandra , Tonon Giovanni , Toppo Stefano , Dorigatti laria , Crisanti Andrea
Published: December 2021

In February and March 2020, one of the first Italian clusters of SARS-CoV-2 infection was detected in the municipality of Vo’. Positive subjects were followed up at 2 and 9 months post-infection with different immuno-assays and a micro-neutralisation test. Here we report on the results of the third serosurvey conducted in the same population in June 2021, 15 months post-infection, when we tested 61% of the infected individuals (n=76). Antibodies against the spike (S) antigen significantly decreased (P<0.006, Kruskal-Wallis test) among unvaccinated subjects (n=35) and increased (P<0.0001) in vaccinated individuals (n=41), whereas those against the nucleocapsid (N) decreased in the whole cohort. From the comparison with two control groups (naïve Vo’ inhabitants (n=20) and healthcare workers (HCW, n=61)), subjects vaccinated post exposure (hybrid immunity) had higher antibody levels (P<0.0001) than subjects vaccinated when naïve. Two doses of vaccine elicited stronger anti-S antibody response than natural infection (P<0.0001). Finally, the neutralising reactivity of sera against the B.1.617.2 (Delta) was lower than compared to the B.1 strain (median 1:320 versus 1:1280 1/dil, P<0.0001, and 1:640 versus 1:2560 1/dil, P=0.0014, after one or two vaccine doses, respectively), although subjects with hybrid immunity maintained neutralising titres above 1:40 1/dil.
Interpreting Mass Spectra Differing from Their Peptide Models by Several Modifications
Authors: Lysiak Albane , Fertin Guillaume , Jean Géraldine , Tessier Dominique
Published: December 2021

Background: In proteomics, mass spectra representing peptides carrying multiple unknown modifications are particularly difficult to interpret. This issue results in a large number of unidentified spectra.Methods: We developed SpecGlob, a dynamic programming algorithm that aligns pairs of spectra – each pair given by a Peptide-Spectrum Match (PSM) – provided by any Open Modification Search (OMS) method. For each PSM, SpecGlob computes the best alignment according to a given score system, interpreting the mass delta within the PSM as one or several unspecified modification(s). All the alignments are provided in a file, using a specific syntax. These alignments are then post-processed by an additional algorithm, which aims at interpreting the detected modifications.Results: Using a large collection of theoretical spectra generated from the human proteome, we demonstrate that running SpecGlob as a post-analysis of an OMS method can significantly increase the number of correctly interpreted spectra, since SpecGlob is able to infer several, and possibly many, modifications. The post-processing algorithm is able to interpret unambiguously most of the modifications detected by SpecGlob in PSMs. In addition, we performed an extensive analysis to provide insight into the potential reasons for incomplete or erroneous interpretations that may remain after alignments of PSMs.Conclusion: SpecGlob is able to correctly align spectra that differ by one or more modification(s) without any a priori. Since SpecGlob explores all possible alignments that may explain the mass delta within a PSM, it reduces interpretation errors generated by incorrect assumptions about the modifications present in the sample or the number and the specificity of modifications carried by peptides. Our results demonstrate that SpecGlob should be relevant to align experimental spectra, even if this consists in a more challenging task.
Controlling Volatility of Wind-Solar Power In Germany
Authors: Lustfeld Hans
Published: December 2021

The main advantage of wind-solar power is the electric power production free of CO2. Its main disadvantage is the huge volatility of the system [national electric energy consumption powered by wind-solar power]. In fact, if this power production, averaged over one year, corresponds to the averaged electric consumption and is intended to replace all other electric power generating devices, then controlling the volatility of this system by using storage alone requires huge capacities of about 30TWh, capacities not available in Germany. However, based on German power data over the last six years (2015 till 2020) we show that the required storage capacity is decisively reduced, provided i) a surplus of wind-solar power is supplied, ii) smart meters are installed, iii) a different kind of wind turbines and solar panels is partially used, iv) a novel function describing this volatile system, is introduced. The new function, in turn, depends on three characteristic numbers, which means, that the volatility of this system is characterized by those numbers. When applying our schemes the results suggest that all the present electric energy in Germany can be obtained from controlled wind-solar power. And our results indicate that controlled wind-solar power can produce the energy for transportation, warm water, space heating and in part for process heating, requirering an increase of the electric energy production by a factor of 5. Then, however, a huge number of wind turbines and solar panels is required changing the appearance of German landscapes fundamentally.
Melanocytic Nevi In Sentinel Lymph Nodes - Association With Cutaneous Nevi And Clinical Relevance In Patients With Cutaneous Melanomas
Authors: Kretschmer Lutz , Schnabel Viktor , Kromer Christian , Bauer-Büntzel Christoph , Richter Annika , Bremmer Felix , Kück Fabian , Julius Katharina , Mitteldorf Chirsitna , Schön Michael P.
Published: December 2021

Purpose: Melanocytic nevi in lymph nodes (NNs) are an important histological differential diagnosis of initial sentinel lymph node (SN) metastasis in melanoma. Our aim was to associate NN in SNs with clinicopathologic features and survival rates in 1 250 patients with SN biopsy for melanoma. Methods: To compare patients with present and absent NN, we used Fisher's exact test, Mann-Whitney U test, and multivariate logistic regression models in this retrospective observational study based on a prospectively maintained institutional database.Results: NN prevalence in axillary, cervical, and groin SNs was 16.5%, 19.4%, and 9.8%, respectively. NN were observed in combination with all growth patterns of melanoma, but more frequently when the primary was histologically associated with a cutaneous nevus. We observed a decreasing NN prevalence with increasing SN metastasis diameter. Multiple logistic regression determined a significantly increased NN probability for SNs of the neck or axilla, for individuals with ≥50 cutaneous nevi, midline primary melanomas, and for individuals who reported non-cutaneous malignancies in their parents. Cancer in parents was also significantly more frequently reported by melanoma patients who had more than 50 cutaneous nevi. In SN-negative patients, NN indicated a tendency for slightly lower melanoma-specific survival.Conclusions: We found a highly significant association between NN diagnosis and multiple cutaneous nevi and provided circumstantial evidence that cutaneous nevi in the drainage area of lymph nodes are particularly important. The trend toward lower melanoma-specific survival in SN-negative patients with NN suggests that careful differentiation of SN metastases is important.
1D and 2D NMR spectra of coffee from 27 countries
Authors: Osorio Javier , Arana Victoria A. , Medina Jessica M. , Alarcon Rodrigo , Moreno Edgar , Wist Julien
Published: December 2021

715 green coffee samples were gathered by Almacafé S.A. (Bogotá, Colombia) between 2012 and 2014 from 27 different countries and analysed at the Nuclear Magnetic Resonance (NMR) laboratory at Universidad del Valle (Cali, Colombia). Over 1000 methanolic coffee extracts were prepared and a total of 4563 spectra were acquired in a fully automatic manner using a 400 MHz NMR spectrometer (Bruker Biospin, Germany). The dataset spans the variance that could be expected for an industrial application of origin monitoring, including samples from different harvest time, collected over several years and processed by at least two distinct operators. The resulting 1D and 2D spectra can be used to develop and evaluate feature extraction methods, multivariate algorithms and automation monitoring techniques, as a dataset for teaching, or as a reference for new studies on similar samples and approach.
Clinical Implications of Oral Assessment In Elderly Patients With Acute Heart Failure: A Single-Center, Retrospective Study
Authors: Uemura Yusuke , Shibata Rei , Ishikawa Haruna , Nagahori Ayumi , Katsumi Yuta , Takemoto Kenji , Ishikawa Shinji , Murohara Toyoaki , Watarai Masato
Published: December 2021

Background: Oral health problems are common and are associated with various geriatric conditions in older adults. The importance of oral health has not been fully highlighted in the assessment and management of patients with heart failure. Here, we investigated the clinical implications of oral assessment in elderly patients with acute heart failure.Methods: We evaluated oral health using the revised oral assessment guide in 77 patients aged 65 years or older who were admitted to hospital for acute heart failure. Poor oral health was defined as a revised oral assessment guide score ≥ 9.Results: Poor oral health was identified in 66.2% of the patients. Patients with poor oral health had high prevalence of decreased physical function, undernutrition, and cognitive impairment. A reduction in the Barthel Index, as an indicator of activities of daily living during hospitalization, was significant in the enrolled patients. The Barthel Index decreased more in patients with poor oral health than those with normal oral health. Furthermore, the revised oral assessment guide score on admission was found to be the only independent predictor of changes in the Barthel Index during hospitalization in the multivariate regression analyses. Conclusions: Oral assessment using the revised oral assessment guide during hospitalization could provide useful information for the management of elderly heart failure patients.Trail registration: Patients were retrospectively registered.
CCST: Cell clustering for spatial transcriptomics data with graph
neural network
Authors: Li Jiachen , Chen Siheng , Pan Xiaoyong , Yuan Ye , Shen Hong-bin
Published: December 2021

Spatial transcriptomics data can provide high-throughput gene expression profiling and spatial structure of tissues simultaneously. An essential question of its initial analysis is cell clustering. However, most existing studies rely on only gene expression information and cannot utilize spatial information efficiently. Taking advantages of two recent technical development, spatial transcriptomics and graph neural network, we thus introduce CCST, Cell Clustering for Spatial Transcriptomics data with graph neural network, an unsupervised cell clustering method based on graph convolutional network to improve ab initio cell clustering and discovering of novel sub cell types based on curated cell category annotation. CCST is a general framework for dealing with various kinds of spatially resolved transcriptomics. With application to five in vitro and in vivo spatial datasets, we show that CCST outperforms other spatial cluster approaches on spatial transcriptomics datasets, and can clearly identify all four cell cycle phases from MERFISH data of cultured cells, and find novel functional sub cell types with different micro-environments from seqFISH+ data of brain, which are all validated experimentally, inspiring novel biological hypotheses about the underlying interactions among cell state, cell type and micro-environment.
Stereotype terhadap Tokoh Utama Perempuan dalam Novel Alun Samudra Rasa karya Ardini Pangastuti Bn
Authors: Setyawan Bagus Wahyu , Hidayah Sa’adatun Nuril , Natsir Ahmad , Fahrudin Ahmad
Published: December 2021

Abstrak: Konflik yang terjadi antara laki-laki dan perempuan menekankan adanya labeling negatif yang tercipta atau stereotip terhadap perempuan selama ini, merupakan salah satu bentuk perubahan sosial dan kemerosotan kualitas moral manusia yang beradab dan beradab. Selain itu, stereotip dapat mengarah pada praktik diskriminatif. Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan bentuk stereotype tokoh utama wanita dalam novel Alun Samudra Rasa karya Ardini pangastuti Bn. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan pendekatan kritik sastra feminis dalam novel Alun Samudra Rasa. Sumber data primer dalam penelitian ini adalah novel Alun Samudra Rasa. Penelitian ini memfokuskan perhatian pada representasi stereotip tokoh utama wanita dalam novel Alun Samudra Rasa. Adanya stereotip dapat menimbulkan kesenjangan dan diskriminasi pada tokoh utama perempuan. Setelah menganalisis data dapat disimpulkan bahwa dalam novel terdapat bentuk stereotip atau pelabelan negatif terhadap tokoh utama perempuan yang dilakukan oleh laki-laki bahkan perempuan yang digambarkan dalam konflik dalam novel.
PERAN GURU PAI DALAM PEMBELAJARAN BERBASIS ‎‎TEKNOLOGI INFORMASI UNTUK MENCEGAH PAHAM ‎‎RADIKALISME SISWA DI SDIT AL-HUSNA GONDANG ‎‎TULUNGAGUNG
Authors: Thohiri M. Kholid , Ernawati Ernawati
Published: December 2021

Abstrak : Guru Pendidikan Islam mempunyai peran vital untuk memberikan pemahaman tentang toleransi dan akidah yang benar dengan tidak mengesampingkan nilai-nilai kebhinekaan dan kebangsaan, sebagai bekal untuk dapat mencegah konflik antar umat Islam maupun umat beragama lain, serta menghindari ajaran radikal untuk mencegah aksi-aksi kekerasan yang mengatasnamakan agama. Dalam penelitian ini mengungkap peran dan upaya strategis guru Pendidikan Agama Islam dalam menangkal radikalisme  melalui pembelajaran berbasis teknologi informasi di SDIT Al-Husna Gondang Tulungagung. Metode penelitian yang digunakan adalah jenis penelitian kualitatif dengan teknik pengumpulan data observasi, wawancara dan dokumentasi. Sedangkan analisis   data dengan langkah reduksi, display data dan konklusi. Teknik  keabsahan data menggunakan trianggulasi dan diskusi sejawat. Hasil penelitiannya adalah peran guru PAI sebagai perencana, mediator, fasilitator, dan filter  dalam proses pembelajaran PAI berbasis teknologi Informasi yang berwawasan nilai-nilai moderasi Islam.

Abstrack: Islamic education teachers have a vital role to provide an understanding of tolerance and the correct creed without neglecting the values ​​of diversity and nationality, as a provision to prevent conflicts between Muslims and other religious communities, and avoid radical teachings to prevent violent acts. In this study reveals the role and strategic efforts of Islamic Religious Education teachers in counteracting radicalism through information technology-based learning at SDIT Al-Husna Gondang Tulungagung. The research method used is a type of qualitative research with observation data collection techniques, interviews and documentation. Meanwhile, data analysis using reduction steps, data display and conclusion drawing. The data validity technique used triangulation and peer discussion. The result of the research is the role of Islamic Education teachers as planners, mediators, facilitators, and filters in the learning process of Islamic Education based on Information technology with the insight into Islamic moderation values.
KETERCAPAIAN PROGRAM SLQ DALAM MENINGKATKAN KEMAMPUAN MEMBACA AL-QUR’AN MAHASISWA PAI UNIVERSITAS MUHAMMADIYAH MALANG
Authors: Thoifah Ianatut , Yusuf Zulfikar , Biantoro Saeful
Published: December 2021

This study aims to determine the achievement of the SLQ program in improving the ability to read Qur’an students of the Islamic Religious Education Program, University Muhammadiyah of Malang. This study uses a descriptive qualitative approach with data analysis of Miles, Huberman and Saldana, namely data condensation where the data is adjusted to the needs and simplified by a percentage to make it easier to read the results, then display and conclusions / verification. The results of this study indicate the achievement of the SLQ program in improving reading Qur’an students of Islamic Religious Education Program consists of five components with a very varied increase, the highest score is dominated by a percentage of 31% PAI students are able to read al Qur'an with makharijul huruf, tajwid and sifatul huruf, in addition to the overall percentage SLQ achievement in improving the Qur’an reading skills of students PAI is 88.28% from100%, then 11.72% are students of PAI did not experience increase in ability from the first abilities possessed during the SLQ activities.
Transversal borderings: Territory and mobility for human rights activists in the Thai-Burma borderlands
Authors: Sharples Rachel
Published: December 2021

In this article I use an interpretation of Saskia Sassen’s ‘cross-border geographies’ as a framing mechanism for the operations of human rights activists in the Thai-Burma borderlands. I argue that these activists use aspects of the national territories they traverse, such as who belongs and associated rights and obligations, as well as state capital and services. But they also act outside of state sovereignty, in particular through digital infrastructures and transnational networking that connect to other national territories, and their irregular movement across the national border. In this way, human rights activists both operate within national territories and in ways that violate their sovereignty. Activist operations are enabled by an informality attached to the Thai-Burma border, its marginal status to central control, its pragmatic approach to state operations, and its porous nature to flows of information and people. Tighter regulation of these territories, particularly as the adjoining states attempt to exert their authority, is likely to impact the ongoing operations of human rights activists in the Thai-Burma borderlands. Cross-border geographies therefore provide a means for the critical examination of activist operations that occur within and across state and non-state spaces.
Spaces of exclusion: The visual construction of Australian borders and the asylum seeker subject in television news reports of the 2013 Australian Federal Election
Authors: Stewart Leicha
Published: December 2021

Policy regarding people arriving by boat in order to seek asylum was a key focus of political discourse during the 2013 Australian Federal Election campaign. Evening television news reports on the unfolding election revealed a bipartisan push for increasingly punitive approaches to the treatment of people seeking asylum. As such borders and the processes and practices involved in discursively constructing them, as well as the linguistic and visual strategies deployed around maintaining and protecting them were dominating themes of political discourse throughout the campaign and the ensuing election coverage.
Debtscape: Australia’s Constitutional Nomopoly
Authors: Giannacopoulos Maria
Published: December 2021

This article reveals the central role played by the Australian constitution in producing the Australian debtscape through the establishment and maintenance of a colonial nomopoly. Australia’s colonial law is foundationally premised upon violent acts of invasion of Indigenous land and water, and because this continues without consent, the colonial state uses its monopoly of violence to manufacture consent through law for two main reasons: the first is to generate retrospective exculpation for historical wrongs and economic theft (the debtscape) and the second is to establish consent frameworks to provide cover for future exploitation and theft (the colonial nomopoly).
The implied border mechanisms of Antarctica: Arguing the case for an Antarctic borderscape
Authors: Nicklin Germana
Published: December 2021

Antarctica is arguably the only geographical territory left on Earth without political borders. Narratives of peace, science and environmental protection in the Antarctic Treaty System drive a collective governance system that avoids border discourse even though physical boundaries exist. This article fills a gap in Antarctic research by exploring the question ‘What borderwork is evident in the Antarctic Treaty System in relation to the construction and maintenance of its physical boundaries?’ through a study of a gateway to Antarctica—New Zealand. Borderscaping and borderwork concepts are used to examine territoriality in Antarctica. Enacted narrative analysis reveals effects of strategic narrative on practices, showing the Antarctic Treaty system has created an ‘implied’ border system that lacks some of the capabilities of an acknowledged border system. The article argues that understanding the full reach of the absences on practices and attitudes in this Antarctic system is important for the continent’s ongoing security and for border theory. It concludes that more needs to be known about the subtle effects on the many actors in this implied borderscape. Such further research will add to knowledge about Antarctic practices and governance and borderscaping theory.
Creative Sovereignty: The In-Between Space: Indigenous Sovereignties in Creative and Comparative Perspective
Authors: WILDCAT MATTHEW , DE LEON JUSTIN
Published: December 2021

Within Indigenous studies the concept of sovereignty has received a wide range of expressions, theories and realizations. Our article covers one part of this vast literature on Indigenous sovereignties by looking at how various books have centered Indigenous sovereignty within their analysis. This survey foregrounds our special issue on creative sovereignty by illustrating the breadth of how Indigenous peoples and scholarship have engaged the concept of sovereignty to both understand the present and imagine different futures. This introductory article for the special issue on Creative Sovereignties does three things: (1) it illustrates that Indigenous sovereignties exist in the in-between space between what is and what is possible, (2) it puts forward a three-part understanding of creativity, and lastly (3) it introduces each of the articles, notes from the field, and creative works featured in this special issue.
Signifying Aboriginal Identity, Culture and Country in Central Queensland Through a Public Art Project
Authors: FREDERICKS BRONWYN , BRADFIELD ABRAHAM
Published: December 2021

Alongside Toonooba (the Fitzroy River) in central Queensland, a series of Aboriginal flood markers are embedded within the earth, commanding attention to the river that flows on one side and the colonial infrastructure of Rockhampton that lies on the other. The flood markers are part of an arts project commissioned by the Queensland Government in 2013 to mark Rockhampton’s history and its relationship to the river. The flood markers, named Honouring Land Connections, assert Indigenous voices into discourses of place, particularly discourses about the significance of rivers on Country. This article explores how art represents wider socio-cultural and politicised contexts of Indigenous and non-Indigenous discourse. The authors discuss the artworks as a form of social action that signifies Rockhampton as an Indigenous space with a history that cannot be neatly divided into three time periods. Any suggestion that Honouring Land Connections represents Rockhampton’s precolonial period disregards Indigenous people’s ongoing connections with and responsibilities for Country. The artworks signify contested spaces, places and knowledge of Country, culture, and waterways. Honouring Land Connections maintains cultural connections and speaks back to White preconceptions of Indigeneity. The artists wage war on the selective readings and colonial amnesia in Australia to directly challenge notions of terra nullius and intellectual nullius. This article shows how art can facilitate interaction through which Aboriginal artists can affirm, negotiate, share, and explore their identities while challenging dominant Eurocentric preconceptions of place and identity.
Changes in the impact of US macroeconomic news on financial markets the example of the Warsaw Stock Exchange
Authors: Gurgul Henryk , Hastenteufel Jessica , Wójtowicz Tomasz
Published: December 2021

Due to the high importance of the American economy, in the past, announcements of US macroeconomic data were shown to have a significant impact on financial markets in general, and on European stock markets in particular. However, as this effect may vary in time, this paper examines the changes in the impact of US macroeconomic news on the WIG20, the main index of the Warsaw Stock Exchange. Based on intraday data from 2004-2019 we study the changes in significance and in the strength of the reaction of WIG20 to announcements of unexpected values of 13 indicators describing the American economy. On the basis of the event study analysis, we describe the reaction of the WIG20 index in the first few minutes after these kinds of announcements.
Agu-Eghwerido distribution, regression model and applications
Authors: Agu Friday Ikechukwu , Eghwerido Joseph Thomas
Published: December 2021

Modelling lifetime data with simple mathematical representations and an ease in obtaining the parameter estimate of survival models are crucial quests pursued by survival researchers. In this paper, we derived and introduced a one-parameter distribution called the Agu-Eghwerido (AGUE) distribution with its simple mathematical representation. The regression model of the AGUE distribution was also presented. Several basic properties of the new distribution, such as reliability measures, mean residual function, median, moment generating function, skewness, kurtosis, coefficient of variation, and index of dispersion, were derived. The estimation of the proposed distribution parameter was based on the maximum likelihood estimation method. The real-life applications of the distribution were illustrated using two real lifetime negatively and positively skewed data sets. The new distribution provides a better fit than the Pranav, exponential, and Lindley distributions for the data sets. The simulation results showed that the increase in parameter values decreases the mean squared error value. Similarly, the mean estimate tends towards the true parameter value as the sample sizes increase.
Towards a target employment rate within age and gender groups
Authors: Jaworski Stanisław , Zielińska-Kolasińska Zofia
Published: December 2021

Quarterly employment rates in European countries are analysed in terms of the likelihood of achieving a specific employment rate within age and gender groups in a five-year horizon. The German employment rate serves as a benchmark for this research. The likelihood is estimated by a Monte-Carlo simulation based on the class of exponential smoothing models. The research presents a pessimistic prognosis of employment rates in European countries with respect to young and partly to older workers.
Developing a Smart Helmet Based on the Internet of Things to Manage Hearing Problems in the Construction Projects
Authors: Abbasianja Hamidreza , Shadhy Vahid Pourali , Beykian Amirhassan
Published: December 2021

Construction sites are renowned as the noisiest places that may cause hearing loss to workers. Lack of awareness about the level of harmful sounds causes more prevalence of hearing loss than other industries. This article intends to solve this issue by an innovative idea that is designing a wearable device called "smart helmet" (SH). The SH uses the concept of the Internet of things (IoT) for real-time monitoring workers' hearing health in construction sites. SH works online to send notifications in the presence of harmful sounds and offline due to storing data to analyse workers' health conditions. The results are divided into two sections: The first section presents the detail of the architecture, hardware and software of the SH and the second section offers a formula to convert noisy situations into allowable working time. By combining the proposed procedure and SH's prepared data, the allowable working time can be calculated for workers. The results of applying this device in practical projects show that steelworkers are more at risk than the others with exposure to 98 dB sounds.
Evaluating the Environmental Performance of 3D Printed Shelters in Jordan
Authors: Akeila Mohanad , Preece Christopher , Kuok King Kuok Kelvin
Published: December 2021

Three-dimensional (3D) printed shelters are an innovative housing solution for those in need of a shelter after a disaster. The Middle East generated a huge number of refugees due to internal conflicts. The technology has been investigated earlier from a cost and time perspectives and has performed better than steel shelters in Jordan. This research article investigates environmental performance of 3D printed shelters in Jordan in terms of energy, fuel, cooling and ventilation. Syrian refugees of Jordanian camps were selected as a case study. The energy simulation of the steel shelter to that of a printed shelter showed that the latter can achieve higher ventilation rates, lower energy consumption, less electricity cost and better thermal insulation than steel shelters.
Community-based water governance for adaptation to water reduction and scarcity in Badulla district of Sri Lanka
Authors: Daluwatte D. D. S. , Sivakumar S.
Published: December 2021

Sustainable Development Goal number 6 declares safe drinking water for all as a human right and it can be used as an indicator to measure development. While urban and municipal residents benefit from safe drinking water through centralized water supply systems, water supply for rural areas and estates were decentralized due to large construction costs, according to the demand-driven approach introducing community governance mechanism for water sources and water supply in rural areas. Community-based water societies emerged as a consequence of this situation. In Badulla district of Sri Lanka, 47% of community-based water societies depend upon natural water springs benefitting 46% of households in a particular area. Recently, two natural water springs dried up affecting 191 households and 10 community-based water societies who depend on natural water springs are regulating their water supply hours due to a long and extended drought situation. This affected 1,953 households in Badulla. Further it represents 8.4% of households who depend upon natural water springs. Owing to the present water scarcity, 37 community-based water societies started catchment protection initiatives with the support of government and non-governmental agencies. One community-based water society in this district has collapsed due to lack of water with the drying up of their natural water spring and another is functioning with an alternative water source. Other community-based water societies are functioning to a varying extent because of water level reduction in natural water springs. While the climate is changing, there are development initiatives that, in particular, are affecting natural water springs.
Effects of hydrogen peroxide preoxidation on clarification and reduction of the microbial load of groundwater and surface water sources for household treatment
Authors: Silva Kamila Jessie Sammarro , Leite Luan de Souza , Fava Natália de Melo Nasser , Daniel Luiz Antonio , Sabogal-Paz Lyda Patricia
Published: December 2021

Household water treatment (HWT) technologies are a promising strategy for addressing the waterborne diseases burden. However, in order to be efficient, these are often limited to water quality and require it to not exceed a certain threshold of physicochemical and microbiological contamination. Additionally, some popular HWTs, such as chlorination, are related to by-product formation. Preoxidation may improve source water quality, and hydrogen peroxide (H2O2) is an oxidant that has not been deeply explored in this specific application, so it could be an innovative approach to HWTs. We investigated effects of H2O2 preoxidation in two natural source waters (surface and groundwater), spiked with a high level of microorganisms. Clarification results suggested this pretreatment may improve life of HWTs. Reduction in microbial load of groundwater was considered ineffective, but 5-min H2O2 preoxidation at 15 mg L−1 led to >4.0 log10 inactivation of Phi X174 coliphage and >3.0 of Escherichia coli in surface water. We believe this performance was increased due to the presence of catalysts in the river water. This raised the point that water quality may be not only impairing, but potentially beneficial to the main HWT and characterization is crucial prior to the implementation of any technologies.
The Potential of Oxidative Stress Related Genes as Prognostic Biomarkers
in Head and Neck Squamous Cell Carcinoma
Authors: Zhou Gang , Wang Xin
Published: December 2021

Background:

The occurrence of oxidative stress is an important hallmark of tumorigenesis
and the development of cancers, including head and neck squamous cell carcinoma (HNSCC).
The purpose of this study was to identify a robust oxidative stress-related prognostic model in
HNSCC.

Methods:

Oxidative stress genes related to the prognosis of HNSCC were identified through multiple
bioinformatics methods.

Results:

The expression profile of differential genes related to oxidative stress and functional enrichment
analysis were obtained from the HNSCC cohort of The Cancer Genome Atlas (TCGAHNSC).
Then, the HNSCC prognostic risk model was constructed of thirteen screened genes
through univariate Cox analysis, the least absolute shrinkage and selection operator (LASSO) Cox
regression, and multivariate Cox analysis. Kaplan–Meier curve indicated that the low-risk group
had a better survival outcome than the high-risk group. The clinical utility of the risk model was
validated in the GSE41613 dataset. The risk score was an independent prognostic indicator in the
training and validation sets. In addition, the risk score was in a positive correlation with tumor
stage, lymph node infiltration, and the status of the primary site. Gene set enrichment analysis
(GSEA) illustrated that many biological processes associated with immunity were significantly enriched
in the low-risk group of the training cohort.

Conclusion::

The oxidative stress-related risk signature was a promising predictor for the prognosis
of HNSCC patients, which might assist in making individualized therapy programs.
The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy
Authors: Chen Kangzhi , Lv Yefan , Long Xiaoyan , Liu Weiping , Zhou Jinxia
Published: December 2021

The prevalence of sleep disorders and cognitive dysfunction has overwhelmingly increased,
with insomnia and Alzheimer’s disease (AD) being the most common form. A multitude
of studies have linked the alterations in sleep continuity or sleep architecture with cognitive impairment
bilaterally, but the management of disrupted sleep patterns in preclinical AD could be more
beneficial since there is no cure for AD. This review mainly focuses on the altered sleep patterns in
insomnia, and summarizes potential pathways underlying the relationship between insomnia and
cognitive impairment, aiming to establish certain sleep pattern changes as biomarkers for cognitive
decline and explore potential therapeutic targets based on evidence from research advances.