bluuebunny/crossref_metadata_2025 huggingface dataset:
Waste from Food and Agro-Food Industries as Pigment Sources: Recovery Techniques, Stability and Food Applications
Authors: Sanna Daniele , Fadda Angela
Published: November 2022

This review discusses the innovative recovery techniques, the stability and the potential applications of pigments attainable from food waste and agro-food industries. It also discusses the effects of the extraction method on the chemical characteristics of the extracted pigments. The main pigment classes, namely anthocyanins, betalains, carotenoids and chlorophylls, are described with a focus on their beneficial health effects, antioxidant properties and chemical stability. The potential applications as food additives are also discussed, taking into account the legislative aspects of their usage, the stability in food matrices and the improvements of food nutritional and organoleptic quality.
Short-Term Outcome of Rehabilitation Program with Hybrid Assistive Limb after Tendon Lengthening in Patients with Cerebral Palsy
Authors: Kuroda Mayumi Matsuda , Mutsuzaki Hirotaka , Nakagawa Shogo , Yoshikawa Kenichi , Takahashi Kazushi , Mataki Yuki , Takeuchi Ryoko , Iwasaki Nobuaki , Yamazaki Masashi
Published: November 2022

In this study, we aimed to evaluate the short-term outcomes of a rehabilitation program with the Hybrid Assistive Limb® after soft tissue lengthening in young patients with cerebral palsy. We assessed six patients with cerebral palsy who underwent soft tissue surgery followed by gait training using the Hybrid Assistive Limb®. Clinical assessments were conducted preoperatively, before, immediately after, and at 1, 2, and 3 months after gait training. Gross Motor Function Measure was improved 5.93 ± 6.11% (mean ± standard deviation, p < 0.05), Canadian Occupational Performance Measure performance was improved 3.12 ± 1.53 points, and satisfaction was improved 3.80 ± 2.14 points (p < 0.05). The knee extension strength on the operated side was changed 7.75 ± 4.97 Nm after the intervention (p = 0.07). In ambulatory patients, gait speed was changed 8.37 ± 1.72 m/min, stride length was changed 10 ± 6.16 cm, and 6 min walking distance was changed 52 ± 16 m after the intervention. Training with the Hybrid Assistive Limb® may improve walking ability and clinical outcomes in young patients with cerebral palsy after soft tissue lengthening.
Long-Term Efficacy and Safety of Evinacumab in Patients with Homozygous Familial Hypercholesterolemia: Real-World Clinical Experience
Authors: Stefanutti Claudia , Chan Dick C. , Di Giacomo Serafina , Morozzi Claudia , Watts Gerald F.
Published: November 2022

Homozygous familial hypercholesterolemia (HoFH) is a rare, genetic condition characterized by markedly elevated plasma low-density lipoprotein cholesterol (LDL-C) concentrations from birth and increased risk of premature atherosclerotic cardiovascular disease. Evinacumab is an inhibitor of angiopoietin-like 3 protein that offers a new approach for correcting high LDL-C in HoFH. Evinacumab was administered intravenously (15 mg/kg Q4W) for 24 months in 7 patients with genetically confirmed HoFH, receiving background lipoprotein apheresis (LA) and/or lipid-lowering treatment (LLT). Assessment of efficacy and safety were carried out before and after 24 months of evinacumab treatment. The LDL-C lowering effect of evinacumab without LA were also investigated in the 7 HoFH patients after a subsequent compassionate extension period. Twenty-four months of treatment with evinacumab against background LA and LLT resulted in a significant reduction in LDL-C (−46.8%; p < 0.001). LDL-C reduction with evinacumab was maintained during the compassionate extensions period in the absence of treatment with LA (−43.4%; mean follow-up of 208 ± 90 days). Evinacumab was well-tolerated, with no major adverse event reported or significant changes in liver and muscle enzyme concentrations. Our findings suggest that evinacumab is a safe and effective treatment for patients with HoFH receiving best standard of care in a routine setting.
Asian Pigeonwing Plants (Clitoria ternatea) Synergized Mesenchymal Stem Cells by Modulating the Inflammatory Response in Rats with Cisplatin-Induced Acute Kidney Injury
Authors: Safhi Fatmah A. , ALshamrani Salha M. , Jalal Areej S. , Awad Nabil S. , Sabit Hussein , Abdelgawad Fathy Elsayed , Khalil Sama S. , Khodeer Dina M. , Mobasher Maysa A.
Published: November 2022

Acute kidney injury is a heterogeneous set of disorders distinguished by a sudden decrease in the glomerular filtration rate, which is evidenced by an increase in the serum creatinine concentration or oliguria and categorized by stage and cause. It is an ever-growing health problem worldwide, with no reliable treatment. In the present study, we evaluated the role of Clitoria ternatea combined with mesenchymal stem cells in treating cisplatin-induced acute kidney injury in rats. Animals were challenged with cisplatin, followed by 400 mg/kg of Asian pigeonwing extract and/or mesenchymal stem cells (106 cells/150 g body weight). Kidney functions and enzymes were recorded, and histopathological sectioning was also performed. The expression profile of IL-1β, IL-6, and caspase-3 was assessed using the quantitative polymerase chain reaction. The obtained data indicated that mesenchymal stem cells combined with the botanical extract modulated the creatinine uric acid and urea levels. Cisplatin increased the level of malondialdehyde and decreased the levels of both superoxide dismutase and glutathione; however, the dual treatment was capable of restoring the normal levels. Furthermore, all treatments modulated the IL-6, IL-1β, and caspase-3 gene expression profiles. The obtained data shed some light on adjuvant therapy using C. ternatea and mesenchymal stem cells in treating acute kidney injury; however, further investigations are required to understand these agents’ synergistic mechanisms fully. The total RNA was extracted from the control, the positive control, and all of the therapeutically treated animals. The expression profiles of the IL-6, IL-1β, and caspase-3 genes were evaluated using the real-time polymerase chain reaction. Cisplatin treatment caused a significant upregulation in IL-6. All treatments could mitigate the IL-6-upregulating effect of cisplatin, with the mesenchymal stem cell treatment being the most effective. The same profile was observed in the IL-1β and caspase-3 genes, except that the dual treatment (mesenchymal stem cells and the botanical extract) was the most effective in ameliorating the adverse effect of cisplatin; it downregulated caspase-3 expression better than the positive control.
Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
Authors: Franc Aleš , Vetchý David , Fülöpová Nicole
Published: November 2022

Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.
A SERPINE1-Based Immune Gene Signature Predicts Prognosis and Immunotherapy Response in Gastric Cancer
Authors: Xu Xiang , Zhang Lipeng , Qian Yan , Fang Qian , Xiao Yongbiao , Chen Guizeng , Cai Guojing , Abula Alimujiang , Wang Zhao , Zhai Ertao , Chen Jianhui , Cai Shirong , Wu Hui
Published: November 2022

Immune checkpoint inhibitors (ICIs) therapy has been successfully utilized in the treatment of multiple tumors, but only a fraction of patients with gastric cancer (GC) could greatly benefit from it. A recent study has shown that the tumor microenvironment (TME) can greatly affect the effect of immunotherapy in GC. In this study, we established a novel immune risk signature (IRS) for prognosis and predicting response to ICIs in GC based on the TCGA-STAD dataset. Characterization of the TME was explored and further validated to reveal the underlying survival mechanisms and the potential therapeutic targets of GC. The GC patients were stratified into high- and low-risk groups based on the IRS. Patients in the high-risk group, associated with poorer outcomes, were characterized by significantly higher immune function. Further analysis showed higher T cell immune dysfunction and probability of potential immune escape. In vivo, we detected the expressions of SERPINE1 by the quantitative real-time polymerase chain reaction (qPCR)in tumor tissues and adjacent normal tissues. In vitro, knockdown of SERPINE1 significantly attenuated malignant biological behaviors of tumor cells in GC. Our signature can effectively predict the prognosis and response to immunotherapy in patients with GC.
Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy
Authors: Arab Hany H. , Abd El Aal Hayat A. , Alsufyani Shuruq E. , El-Sheikh Azza A. K. , Arafa El-Shaimaa A. , Ashour Ahmed M. , Kabel Ahmed M. , Eid Ahmed H.
Published: November 2022

Topiramate, a promising drug classically used for the management of neurological disorders including epilepsy and migraine, has demonstrated marked anti-inflammatory and anti-apoptotic actions in murine models of cardiac post-infarction inflammation, wound healing, and gastric/intestinal injury. However, its potential impact on cadmium-induced testicular injury remains to be elucidated. Herein, the present study aimed to explore the effect of topiramate against cadmium-invoked testicular impairment with emphasis on the molecular mechanisms linked to inflammation, apoptosis, and autophagy. Herein, administration of topiramate (50 mg/kg/day, by gavage) continued for 60 days and the testes were examined by histology, immunohistochemistry, and biochemical assays. The present data demonstrated that serum testosterone, sperm count/abnormalities, relative testicular weight, and histopathological aberrations were improved by topiramate administration to cadmium-intoxicated rats. The rescue of testicular dysfunction was driven by multi-pronged mechanisms including suppression of NLRP3/caspase-1/IL-1β cascade, which was evidenced by dampened caspase-1 activity, lowered IL-1β/IL-18 production, and decreased nuclear levels of activated NF-κBp65. Moreover, curbing testicular apoptosis was seen by lowered Bax expression, decreased caspase-3 activity, and upregulation of Bcl-2. In tandem, testicular autophagy was activated as seen by diminished p62 SQSTM1 accumulation alongside Beclin-1 upregulation. Autophagy activation was associated with AMPK/mTOR pathway stimulation demonstrated by decreased mTOR (Ser2448) phosphorylation and increased AMPK (Ser487) phosphorylation. In conclusion, combating inflammation/apoptosis and enhancing autophagic events by topiramate were engaged in ameliorating cadmium-induced testicular impairment.
Population Pharmacokinetics of Doxycycline, Administered Alone or with N-Acetylcysteine, in Chickens with Experimental Mycoplasma gallisepticum Infection
Authors: Petkova Tsvetelina , Yordanova Antoaneta , Milanova Aneliya
Published: November 2022

Mycoplasmosis is a bacterial infection that significantly affects poultry production, and it is often controlled with antibiotics, including doxycycline. The conducted study aimed to determine population pharmacokinetic (PopPk) parameters of doxycycline in healthy (n = 12) and in Mycoplasma gallisepticum-challenged (n = 20) chickens after its oral administration via drinking water at the registered dose rate of 20 mg/kg b.w./24 h for five days, without or with co-administration of N-acetylcysteine (NAC, a dose of 100 mg/kg b.w./24 h) via the feed. Doxycycline concentrations in plasma were analyzed with the LC-MS/MS method. The values of tvV/F and tvke were 4.73 L × kg−1 and 0.154 h−1, respectively, and they showed low BSV. A high BSV of 93.17% was calculated for the value of tlag of 0.8 h, which reflects the inter-individual differences in the water consumption. PTA was computed after Monte Carlo simulation with the registered dose for doxycycline. The target of %fT > MIC ≥ 80% and 100% can be achieved in 90% of the broiler population, after a correction for protein binding, for bacteria with MIC ≤ 0.5 mg × L−1 and 0.25 mg × L−1, respectively. The applied PopPk model did not reveal significant effect of M. gallisepticum infection and co-administration of NAC on pharmacokinetic parameters of doxycycline.
Pharmacogenetic Study of the Impact of ABCB1 Single Nucleotide Polymorphisms on the Response to Cyclosporine in Psoriasis Patients
Authors: Chernov Alexandr , Kilina Daria , Smirnova Tatiana , Galimova Elvira
Published: November 2022

Psoriasis is a chronic, T cell-mediated skin disease affecting 2–3% of the Caucasian population. Cyclosporine A is a calcineurin inhibitor that acts selectively on T cells. The cyclosporine A treatment response has been suggested to be modulated by single-nucleotide polymorphisms (SNPs) in the ABCB1 gene. The aim of this research was to evaluate the effect of ABCB1 genetic variants that could affect the response to a cyclosporine treatment in Russian psoriasis patients with the ABCB1 genotype status. The ABCB1 T-129C, G1199A, C1236T, G2677T/A and C3435T SNPs in the 168 patients with psoriasis were genotyped by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) and TaqMan SNP genotyping assays. The ABCB1 C1236T, G2677T/A and C3435T SNPs were significantly associated with a negative response to cyclosporine therapy. A very strong association was evident for the C3435T SNP in the ABCB1 gene in the allele, dominant and recessive models (OR = 2.58, OR = 4.01, OR = 2.50, respectively). ABCB1 C1236T and G2677T/A polymorphisms were significantly associated with a negative response to the cyclosporine therapy in the codominant, dominant and recessive models (p ˂ 0.05). Additionally, the haplotype analysis identified that the TGC haplotype is significantly associated with a negative response to cyclosporine therapy in psoriasis patients (p ˂ 0.05). The current study to the best of our knowledge is the first of its kind to be performed in the Russian population. In conclusion, the present results suggest an association between the ABCB1 genetic variants and unresponsiveness to cyclosporine in the Russian population. Further, larger studies are necessary to confirm our findings and replicate them in various ethnic populations before its implementation in the clinical practice.
The Therapeutic Potential of Chemo/Thermotherapy with Magnetoliposomes for Cancer Treatment
Authors: Toro-Córdova Alfonso , Llaguno-Munive Monserrat , Jurado Rafael , Garcia-Lopez Patricia
Published: November 2022

Cancer represents a very grave and quickly growing public health problem worldwide. Despite the breakthroughs in treatment and early detection of the disease, an increase is projected in the incidence rate and mortality during the next 30 years. Thus, it is important to develop new treatment strategies and diagnostic tools. One alternative is magnetic hyperthermia, a therapeutic approach that has shown promising results, both as monotherapy and in combination with chemo- and radiotherapy. However, there are still certain limitations and questions with respect to the safety of the systemic administration of magnetic nanoparticles. To deal with these issues, magnetoliposomes were conceived as a new generation of liposomes that incorporate superparamagnetic nanoparticles and oncological pharmaceuticals within their structure. They have the advantage of targeted and selective drug delivery to the diseased organs and tissues. Some of them can avoid the immune response of the host. When exposed to a magnetic field of alternating current, magnetoliposomes produce hyperthermia, which acts synergistically with the released drug. The aim of the present review is to describe the most recent advances in the use of magnetoliposomes and point out what research remains to be done for their application to chemo-thermal therapy in cancer patients.
Mouse Syngeneic Melanoma Model with Human Epidermal Growth Factor Receptor Expression
Authors: Slastnikova Tatiana A. , Rosenkranz Andrey A. , Ulasov Alexey V. , Khramtsov Yuri V. , Lupanova Tatiana N. , Georgiev Georgii P. , Sobolev Alexander S.
Published: November 2022

The development of epidermal growth factor receptor (EGFR)-targeting agents for the treatment of malignant melanoma requires cheap and easy animal tumor models for high-throughput in vivo screening. Thus, the aim of this study was to develop mouse syngeneic melanoma model that expresses human EGFR. Cloudman S91 clone M3 mouse melanoma cells were transduced with lentiviral particles carrying the human EGFR gene followed by a multistep selection process. The resulting M3-EGFR has been tested for EGFR expression and functionality in vitro and in vivo. Radioligand assay confirmed the presence of 13,900 ± 1500 EGF binding sites per cell at a dissociation constant of 5.3 ± 1.4 nM. M3-EGFR demonstrated the ability to bind and internalize specifically and provide the anticipated intracellular nuclear import of three different EGFR-targeted modular nanotransporters designed for specific anti-cancer drug delivery. Introduction of the human EGFR gene did not alter the tumorigenicity of the offspring M3-EGFR cells in host immunocompetent DBA/2J mice. Preservation of the expression of EGFR in vivo was confirmed by immunohistochemistry. To sum up, we successfully developed the first mouse syngeneic melanoma model with preserved in vivo expression of human EGFR.
Efficacy and Safety of Upadacitinib for Management of Moderate-to-Severe Atopic Dermatitis: An Evidence-Based Review
Authors: Lytvyn Yuliya , Mufti Asfandyar , Abduelmula Abrahim , Sachdeva Muskaan , Maliyar Khalad , Georgakopoulos Jorge R. , Yeung Jensen
Published: November 2022

Atopic dermatitis (AD) is a common skin condition characterized by inflammation that presents with erythematous and pruritic skin. Its chronic relapse-remitting nature has a significant impact on the quality of life, and often requires ongoing management. Given the limited treatments available for AD, there remains a large need for effective and safe alternative therapies for long-term use. Janus kinase (JAK) inhibitors are a new class of agents that target the JAK-STAT pathway, which plays an important role in the production of proinflammatory cytokines involved in AD pathogenesis. Phase II and III clinical trials revealed that JAK inhibitors, such as upadacitinib, are effective and well-tolerated agents for the treatment of moderate-to-severe AD. As a result, upadacitinib was approved for use in patients with moderate-to-severe AD by the European Medicines Agency (2021), Health Canada (2021) and the FDA (2022) in the last year. It is important for dermatologists to be aware of the clinical evidence to continue incorporating the use of upadacitinib into the treatment algorithm for AD, which will ultimately lead to improved patient outcomes. Therefore, this review is an up-to-date summary of the clinical data available on the efficacy and safety of upadacitinib treatment for AD.
Modulating Expression Levels of TCP Transcription Factors by Mentha x piperita Volatiles—An Allelopathic Tool to Influence Leaf Growth?
Authors: Preusche Matthias , Vahl Marvin , Riediger Johanna , Ulbrich Andreas , Schulz Margot
Published: November 2022

Peppermint (Mentha x piperita) is a species with inhibitory allelopathic properties due to its high amounts of terpenes. Recent studies have disclosed dosage dependent growth promotion or defense reactions in plants when facing appropriate amounts of Mentha bouquet terpenes. These positive effects could be of interest for agricultural applications. To obtain more insights into leaf growth modulations, the expression of Arabidopsis and Brassica rapa TCP transcription factors were studied after fumigation with M. x piperita bouquets (Arabidopsis), with M. x piperita essential oil or with limonene (Arabidopsis and Chinese cabbage). According to qPCR studies, expression of TCP3, TCP24, and TCP20 were downregulated by all treatments in Arabidopsis, leading to altered leaf growth. Expressions of B. rapa TCPs after fumigation with the essential oil or limonene were less affected. Extensive greenhouse and polytunnel trials with white cabbage and Mentha plants showed that the developmental stage of the leaves, the dosage, and the fumigation time are of crucial importance for changed fresh and dry weights. Although further research is needed, the study may contribute to a more intensive utilization of ecologically friendly and species diversity conservation and positive allelopathic interactions in future agricultural systems.
Highly Efficient Adsorption of Tetracycline Using Chitosan-Based Magnetic Adsorbent
Authors: da Silva Bruckmann Franciele , Schnorr Carlos Eduardo , da Rosa Salles Theodoro , Nunes Franciane Batista , Baumann Luiza , Müller Edson Irineu , Silva Luis F. O. , Dotto Guilherme L. , Bohn Rhoden Cristiano Rodrigo
Published: November 2022

Herein, tetracycline adsorption employing magnetic chitosan (CS·Fe3O4) as the adsorbent is reported. The magnetic adsorbent was synthesized by the co-precipitation method and characterized through FTIR, XRD, SEM, and VSM analyses. The experimental data showed that the highest maximum adsorption capacity was reached at pH 7.0 (211.21 mg g−1). The efficiency of the magnetic adsorbent in tetracycline removal was dependent on the pH, initial concentration of adsorbate, and the adsorbent dosage. Additionally, the ionic strength showed a significant effect on the process. The equilibrium and kinetics studies demonstrate that Sips and Elovich models showed the best adjustment for experimental data, suggesting that the adsorption occurs in a heterogeneous surface and predominantly by chemical mechanisms. The experimental results suggest that tetracycline adsorption is mainly governed by the hydrogen bonds and cation–π interactions due to its pH dependence as well as the enhancement in the removal efficiency with the magnetite incorporation on the chitosan surface, respectively. Thermodynamic parameters indicate a spontaneous and exothermic process. Finally, magnetic chitosan proves to be efficient in TC removal even after several adsorption/desorption cycles.
Supramolecular Combination Cancer Therapy Based on Macrocyclic Supramolecular Materials
Authors: Li Yilin , Su Yuteng , Li Zhaoxiang , Chen Yueyue
Published: November 2022

Supramolecular combination therapy adopts supramolecular materials to design intelligent drug delivery systems with different strategies for cancer treatments. Thereinto, macrocyclic supramolecular materials play a crucial role in encapsulating anticancer drugs to improve anticancer efficiency and decrease toxicity towards normal tissue by host–guest interaction. In general, chemotherapy is still common therapy for solid tumors in clinics. However, supramolecular combination therapy can overcome the limitations of the traditional single-drug chemotherapy in the laboratory findings. In this review, we summarized the combination chemotherapy, photothermal chemotherapy, and gene chemotherapy based on macrocyclic supramolecular materials. Finally, the application prospects in supramolecular combination therapy are discussed.
Supported Imidazolium-Based Ionic Liquids on a Polysulfone Matrix for Enhanced CO2 Capture
Authors: Domingo Huguet David , Gual Aitor , Garcia-Valls Ricard , Nogalska Adrianna
Published: November 2022

The present work demonstrates the potential for improved CO2 capture capabilities of ionic liquids (ILs) by supporting them on a polysulfone polymeric matrix. CO2 is one of the main gases responsible for the greenhouse effect and is a focus of The European Commission, which committed to diminishing its emission to 55% by 2023. Various ILs based on combinations of 1-butyl-3-methyl- imidazolium cations and different anions (BMI·X) were synthesized and supported on a polysulfone porous membrane. The influence of the membrane structure and the nature of ILs on the CO2 capture abilities were investigated. It was found that the membrane’s internal morphology and its surface characteristics influence its ILs sorption capacity and CO2 solubility. In most of the studied configurations, supporting ILs on porous structures increased their contact surface and gas adsorption compared to the bulk ILs. The phenomenon was strongly pronounced in the case of ILs of high viscosity, where supporting them on porous structures resulted in a CO2 solubility value increase of 10×. Finally, the highest CO2 solubility value (0.24 molCO2/molIL) was obtained with membranes bearing supported ILs containing dicarboxylate anion (BMI.MAL).
Ballistic Limit of UHMWPE Composite Armor under Impact of Ogive-Nose Projectile
Authors: Ding Li , Gu Xiaohui , Shen Peihui , Kong Xiangsheng
Published: November 2022

The ballistic response of armor has been widely used to evaluate its feasibility and advantages as a protective structure. To obtain the ballistic performance and ballistic limitations of composite armor, a type of ultra–high molecular weight polyethylene (UHMWPE) composite armor is designed, which is composed of UHMWPE laminates and steel face sheets of Q235. The total thickness of the armor is 53 mm, with an in–plane dimension of 300 mm × 300 mm. Then, an experimental study of the ballistic impact response of composite armor subject to a typical ogive–nose projectile was carried out. In the velocity range of 501.1 to 1026.1 m/s, the 14.5 mm caliber armor–piercing projectile could penetrate through the composite armor. At the velocity of 433.3 m/s, the A–P projectile was embedded in the armor, leaving a bulge mark on the back sheet. Therefore, 467.2 m/s is taken as the ballistic limit of the armor under the impact of the ogive–nose projectile. In addition, a corresponding numerical simulation model is also established to predict the ballistic limit of the projectile. The numerical predictions are consistent with the experimental results. The ballistic limit obtained from the numerical simulation results is 500 m/s, which is acceptable with a relative error of 7.02%. The failure mechanism of the composite armor is also obtained. Petaling is the main dominant failure mode for both face sheets, while delamination and shear failure dominate the penetration process of UHMWPE laminates. Finally, the perforation mechanism of composite armor under the impact of an A–P projectile is analyzed with theoretical models to predict the residual velocity, the work performed during the perforation, and the resisting stress of σs in the cavity–expansion model. The experimental and numerical simulation results can provide necessary data in the analysis of the composite structure’s dynamic response under the impact of sharp head penetrators. The research results present the ballistic performance, failure mechanism, and ballistic limit of the composite armor under the impact of a typical ogive–nose projectile, which can be significant in the design of composite armor in the areas of ship shield, fortifications protection, and bulletproof structures against threats from sharp head penetrators.
Reusable Macroporous Oil Sorbent Films from Plastic Wastes
Authors: Saleem Junaid , Baig Moghal Zubair Khalid , Luyt Adriaan Stephanus , Shakoor Rana Abdul , Mansour Said , McKay Gordon
Published: November 2022

Plastic waste comprises 15% of the total municipal solid waste and can be a rich source for producing value-added materials. Among them, polyethylene (PE) and polypropylene (PP) account for 60% of the total plastic waste, mainly due to their low-end and one-time-use applications. Herein, we report reusable oil sorbent films made by upcycling waste PE and PP. The as-prepared oil sorbent had an uptake capacity of 55 g/g. SEM analysis revealed a macroporous structure with a pore size range of 1–10 µm, which facilitates oil sorption. Similarly, the contact angle values reflected the oleophilic nature of the sorbent. Moreover, thermal properties and crystallinity were examined using DSC, while mechanical properties were calculated using tensile testing. Lastly, 95% of the sorbed oil could be easily recovered by squeezing mechanically or manually.
Physical, Chemical, and Mechanical Properties of Six Bamboo from Sumatera Island Indonesia and Its Potential Applications for Composite Materials
Authors: Hartono Rudi , Iswanto Apri Heri , Priadi Trisna , Herawati Evalina , Farizky Farhan , Sutiawan Jajang , Sumardi Ihak
Published: November 2022

The suitability of bamboo’s basic characteristics is very important for more specific purposes, such as composite raw materials. Anatomical, physical, mechanical, and chemical characteristics are some of bamboo’s fundamental characteristics. This study analyses the basic properties, such as physical, mechanical, and chemical properties of bamboo from the Forest Area with Special Purpose (FASP) Pondok Buluh Sumatera Island, Indonesia (I); analyses the relationship between the properties of each type of bamboo (II); and chooses the type of bamboo with the best properties that have the potential to be applied to composite materials, such as laminated bamboo (III). This study used materials consisting of six species of bamboo from the FASP Pondok Buluh. The manufacture of physical and mechanical test samples refers to the ISO 22157 standard, 2004, while the chemical properties test refers to the TAPPI 1999 standard. The chemical, physical, and mechanical properties of bamboo vary widely among species. The lowest holocellulose and α-cellulose content were found in the Kuning Bamboo (B. vulgaris var. vittata). The content of holocellulose and α-cellulose causes the lowest density in Kuning Bamboo (B. vulgaris var. vittata). The Dasar Bamboo (Bambusa vulgaris) has the highest levels of lignin. The substances have an impact on moisture content, T/R ratio, and shear strength. The Dasar Bamboo (Bambusa vulgaris) has the lowest moisture content, the highest T/R ratio, and the highest shear strength. However, Betung Bamboo (Dendrocalamus asper) has the highest density in this study. The compressive strength of the Betung Bamboo (Dendrocalamus asper) has the highest value. Therefore, Betung bamboo and Dasar Bamboo in this study were potentially utilized for composite materials, such as laminated bamboo.
Relaxation and Amorphous Structure of Polymers Containing Rigid Fumarate Segments
Authors: Suzuki Yasuhito , Kano Takahito , Tomii Tsuyoshi , Tsuji Nagisa , Matsumoto Akikazu
Published: November 2022

The physical properties of polymers are significantly affected by relaxation processes. Recently, we reported that poly(diethyl fumarate) (PDEF) shows two thermal anomalies on DSC measurement, despite the fact that it is a homopolymer. We attribute these two relaxations α relaxation and β relaxation, respectively. In this study, we investigate the two relaxations of fumarate-containing polymers by DSC, solid-state NMR, and X-ray scattering. The two relaxations are present even in a copolymer of diethyl fumarate and ethyl acrylate with fumarate segments of 30%. We used poly(methyl methacrylate) (PMMA) as a model polymer for comparison, since there are detailed investigations of its dynamics and physical properties. Solid-state NMR indicates that the very local relaxation of poly(fumarate)s is not significantly different from that of PMMA. The tensile test showed that PDEF is still brittle at above β relaxation temperature and below α relaxation temperature. It was revealed that a structural anisotropy appeared when PDEF was extended at around α relaxation temperature. We discuss the effect of the glassy packing of the rigid polymer chain including the DEF segments on the strong β relaxation behavior. Our data provide insight into the microscopic mechanism of β relaxation of vinyl polymers.
Influence of Fiber Content and Dosing Position on the the Mechanical Properties of Short-Carbon-Fiber Polypropylene Compounds
Authors: Höftberger Thomas , Dietrich Florian , Zitzenbacher Gernot , Burgstaller Christoph
Published: November 2022

The properties of short-fiber-reinforced composites depend on the fiber length of the reinforcing fibers. This fiber length is typically influenced by processing to different extents. In this work, we investigate the influence of processing, i.e., the influence of residence time achieved via different dosing points in compounding, and the fiber content on the fiber length and mechanical properties of short-carbon-fiber-reinforced polypropylene. We found that, with increasing fiber content, the fiber length decreases from 900 to 300 µm after compounding and from 500 to 250 µm after injection molding. Additionally, a decrease in residence time in the compounder leads to an increase in the fiber length of approx. 300 µm compared to the longer residence time. This is later reduced by the injection molding step, but the longer fibers are still longer in the final molded test specimen, thus resulting in a 5–10% increased tensile strength and elastic modulus as well as an some increase in impact strength. As the injection molding step showed considerable fiber length reduction (down to 250 µm), further investigations of injection molding should be undertaken to preserve fiber length better for the increased performance of these composites.
Effect of Ultraviolet—A Radiation on Alicyclic Epoxy Resin and Silicone Rubber Used for Insulators
Authors: Wang Xiaoqing , Fan Haonan , Li Wenrong , Zhang Yuyang , Shang Ruiqi , Yin Fanghui , Wang Liming
Published: November 2022

Compared with the high-temperature vulcanized silicone rubber (HTVSR) insulator, the alicyclic epoxy resin insulator has higher hardness and better bonding between the core and the sheath. This makes the latter very promising in the coastal area of Southern China. Outdoor insulators are often subjected to high intensity of ultraviolet (UV)-A radiation. The influence of UV-A radiation is significant for alicyclic epoxy resin insulators. To help address the concern, the surface of two kinds of samples, namely the alicyclic epoxy resin insulator and HTVSR insulator, with UV-A aging time was characterized by tests of scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR). The operation properties (mechanical properties, hydrophobicity) for outdoor insulators were also analyzed. It was found that the appearance color of the alicyclic epoxy resin has changed greatly, and there is a certain degree of fading. The mechanical properties of the alicyclic epoxy resin are maintained well and, the hydrophobicity decreases gradually. For silicone rubber, the appearance color change of silicone rubber is smaller, and the mechanical properties of silicone rubber decreased greatly. In addition, although the hydrophobicity of silicone rubber decreased gradually, it is still better than that of alicyclic epoxy resin. Both materials have broken chemical bonds, but the degree is relatively light, which meets the requirements of insulators for outdoor operation.
Effective Tensile Strength Estimation of Natural Fibers through Micromechanical Models: The Case of Henequen Fiber Reinforced-PP Composites
Authors: Espinach Francesc Xavier , Julian Fernando , Alcalà Manel , Vilaseca Fabiola , Carrasco Félix , Mutjé Pere
Published: November 2022

The performance of henequen fibers and polypropylene composites obtained by injection molding with and without coupling agent was evaluated. Henequen fibers are natural non-wood fibers mainly used in textile sector or in thermosetting matrix composites. In this work, henequen fibers have been used as a possible substitute reinforcement material for sized glass fibers. The surface charge density of the materials used was evaluated, as well as the morphology of the fibers inside the material. A significant reduction in the length of the fibers was observed as a consequence of the processing. The use of a 4% coupling agent based on fiber content was found to be effective in achieving significant improvements in the tensile strength of the composites in the reinforcement range studied. The influence of the aspect ratio on the coupling factor was determined, as well as the evaluation of the interface quality. The results obtained demonstrate the great potential of henequen fibers as reinforcement of composite materials, giving rise to strong interfaces with coupling. Finally, the comparison of henequen fiber composites with sized glass fiber composites showed that it is possible to substitute polypropylene composites with 20 wt.% glass fiber for 50 wt.% henequen fibers.
Multiaxial Deformations of Elastomeric Skins for Morphing Wing Applications: Theoretical Modeling and Experimental Investigations
Authors: Ahmad Dilshad , Kumar Deepak , Ajaj Rafic M.
Published: November 2022

An elastomeric class of flexible skin-based polymorphing wings changes its configuration to maximize performance at radically different flight conditions. One of the key design challenges for such an aircraft technology is the multiaxial deformation characterization and modeling of nonlinear elastomeric skins of polymorphing wings. In the current study, three elastomeric materials, Latex, Oppo, and Ecoflex, are experimentally characterized and modeled under all possible deformation modes such as uniaxial, pure shear, biaxial, and equibiaxial relevant for flexible skin-based morphing wing applications. Additionally, a novel material model with four material constants is proposed to model the considered elastomers-based morphing wings keeping all the material parameters constant for all the possible deformation modes. The present experimental and theoretical study provides a concise comparative study of the three elastomers used in the morphing wings tested in all possible deformation modes.
Zn (II) Porphyrin Built-in D–A Covalent Organic Framework for Efficient Photocatalytic H2 Evolution
Authors: Lv Mingbo , Ren Xitong , Cao Ronghui , Chang Zhiming , Chang Xiao , Bai Feng , Li Yusen
Published: November 2022

Covalent organic frameworks (COFs) with donor–acceptor (D–A) units are credible photocatalysts for their per-designed structure, inherent porosity, large surface area, splendid stability and so forth. Developing COFs with an excellent photocatalytic efficiency for hydrogen evolution is of a great significance in alleviating the energy crisis. Herein, a D–A type imine-linked crystalline Zn-Por-TT COF was fabricated successfully via the co-polymerization of electron-deficient Zinc (II) 5,10,15,20-tetrakis(para-aminophenyl) porphyrin (Zn-TAPP), and electron-rich thieno[3,2-b]thiophene-2,5-dicarbaldehyde (TT). Profiting from the D–A complex structure, the obtained Zn-Por-TT COF showcases an excellent photocatalytic activity with a hydrogen evolution rate of 8200 μmol/g/h, while the Zn-TAPP monomer presents practically no capacity for the generation of hydrogen under identical conditions. In addition, the counterparts Por-TT COF and COF-366-Zn were employed to illustrate the enhancement of the photocatalytic performance by metal catalytic sites and D–A structures. In addition, the counterparts Por-TT COF and COF-366-Zn were employed to illustrate the enhancement of metal catalytic sites and D–A structures for the photocatalytic performance.
Study on SBS Optimal Block Ratio Based on Molecular Simulation
Authors: Liu Wenyue , Zheng Chuanfeng , Luo Haisong , Yang Xue , Lin Zhi
Published: November 2022

The block ratio of SBS is an important factor influencing the swelling effect of modified asphalt, but the effect of the block ratio in the swelling process cannot be accurately studied by macro testing. In order to solve this problem and screen out the optimal SBS block ratio, molecular models of asphalt and SBS with different block ratios were established by molecular simulation technology at the microscopic level, and an asphalt–SBS interaction layer system was established on this basis. The diffusion and adhesion effects of SBS with different block ratios were evaluated by calculating the immersion depth, diffusion coefficient, and adhesion work of SBS in asphalt. The results show that SBS has a physical cross-linking reaction with asphalt during swelling, and SBS with a higher butadiene block ratio exhibits a deeper immersion depth; thus, SBS with a 3/7 block ratio has the best performance in the modification process, which is superior to SBS with other block ratios, in terms of both the diffusion and adhesion effect. The performance of asphalt modified by SBS with different block ratios was tested using penetration, softening point, and ductility, and the results were consistent with the simulation results, which proved the reliability of the microscopic conclusions from a macro perspective.
Campus as Sacred Ground: Laying the Foundation for Well-Being
Authors: Clausén Marie
Published: November 2022

There are accounts of increasing anxiety, depression, and other mental health issues among students and staff at many universities, including the University of Ottawa—accounts borne out by official numbers of referrals to mental health practitioners. The causes of these issues are frequently sought within individuals themselves; the solutions are assumed to lie in therapy, counseling, or medication. In cases where the reasons are sought externally, they are attributed to workloads, interpersonal conflicts, racism, sexism, or financial difficulties. These are all, without a doubt, valid causes for ill health. Could another reason for the seemingly general failure to thrive among staff, faculty, and students on the University of Ottawa campus, however, be connected to the campus itself? It is, after all, a known fact that we are all dependent upon and deeply reactive to our environments. From Vitruvius to Ruskin to Pallasmaa, theorists have made the link between the built environment—architecture—and wellness. Architecture has the power to make us feel anxious, alienated, and unseen, or to increase our sense of belonging, collective and individual identity, sense of place, security, and tranquillity. Sacred architecture appears to play a particularly pivotal role in this—to people of all faiths and none. This paper seeks to explore whether the University of Ottawa could potentially reverse the upwardly trending numbers of poor mental health by creating a sacred-architecture-centric campus that meaningfully and materially honours not only the school’s history and motto, but also its location in the Ottawa valley, on the unceded land of the Algonquin, as well as the current religious and cultural diversity of its students.
The Temporal Evolution of F-Region Equatorial Ionization Anomaly Owing to the 2022 Tonga Volcanic Eruption
Authors: Zhang Kedeng , Wang Hui , Zhong Yunfang , Xia Hao , Qian Chengyu
Published: November 2022

The dynamic evolutions of the noon ionospheric Equatorial Ionization Anomaly (EIA) owing to the 2022 Tonga volcanic eruption were investigated using the ionospheric plasma measurements from the Swarm satellite, the science experiment of the Constellation Observing Systems for Meteorology, Ionosphere, and Climate (COSMIC) mission, and the thermospheric wind observations from the Ionospheric Connection Explorer (ICON). At 14.1 universal time (UT), the noon EIA was enhanced for the upward plasma drifts, when the F2-layer was significantly uplifted from 360 km to 410 km. At 15.6 UT, because of the downward drifts, the intensity of the EIA reduced, and hmF2 decreased to 270 km. At 17–18 UT, the EIA recovered and reformed, and hmF2 increased to 350 km. A two-peak structure in the plasma was observed at Swarm altitudes. The temporal evolution might be related to the vertical plasma drifts (both downward and upward) from the E-region electric field.
Surface Water Mapping and Flood Monitoring in the Mekong Delta Using Sentinel-1 SAR Time Series and Otsu Threshold
Authors: Tran Khuong H. , Menenti Massimo , Jia Li
Published: November 2022

The annual flood and the alteration in hydrological regimes are the most vital concerns in the Vietnamese Mekong Delta (VMD). Although synthetic aperture radar (SAR) Sentinel-1 imagery is widely used for water management, only a few studies have used Sentinel-1 data for mapping surface water and monitoring flood events in the VMD. This study developed an algorithm to implement (i) automatic Otsu threshold on a series of Sentinel-1 images to extract surface water and (ii) time series analyses on the derived surface water maps to detect flood water extent in near-real-time (NRT). Specifically, only cross-polarized VH was selected after an assessment of different Sentinel-1 polarizations. The dynamic Otsu thresholding algorithm was applied to identify an optimal threshold for each pre-processed Sentinel-1 VH image to separate water from non-water pixels for producing a time series of surface water maps. The derived Sentinel-1 surface water maps were visually compared with the Sentinel-2 Full Resolution Browse (FRB) and statistically examined with the Sentinel-2 Multispectral Instrument (MSI) surface water maps, which were generated by applying the Otsu threshold on the normalized difference water index (NDWI) and modified normalized difference water index (MNDWI) images. The visual comparison showed a strong correspondence between the Sentinel-1 surface water maps and Sentinel-2 FRB images in three periods, including rice’s sowing season, flood period, and rice’s maturation stage. A good statistical agreement suggested that the performance of the dynamic Otsu thresholding algorithm on Sentinel-1 image time series to map surface water is effective in river areas (R2 = 0.97 and RMSE = 1.18%), while it is somewhat lower in paddy field areas (R2 = 0.88 and RMSE = 3.88%). Afterward, a flood mapping algorithm in NRT was developed by applying the change-detection-based time series analyses on the derived Sentinel-1 surface water maps. Every single pixel at the time t  is respectively referred to its state in the water/non-water and flooded/non-flooded maps at the previous time t−1 to be classified into a flooded or non-flooded pixel. The flood mapping algorithm enables updates at each time step to generate temporal flood maps in NRT for monitoring flood water extent in large-scale areas. This study provides a tool to rapidly generate surface water and flood maps to support water management and risk reduction in the VMD. The future improvement of the current algorithm is discussed.