bluuebunny/crossref_metadata_2025 huggingface dataset:
THE DIGITAL ECONOMY: TOPICAL ISSUES OF THEORY AND PRACTICE
Authors: Khomenko E.B.
Published: May 2021

The modern stage of economic development in world and Russian economic science and master practice is commonly called the digital economy. Digitalization had made significant adjustments to all spheres of society, sparking a scientific debate on the substance and content of such concepts as “digital economy”, “digital sector of the economy”, “digital literacy”. Due to the fact that the theory and practice of digital economy are currently being orally developed, there are a lot of differences in the use of these terms in science and practice, which requires additional scientific research in the field of systematizing the conceptual provisions of the theory of digital economy. This situation is complicated by the multidisciplinary nature of the issues under consideration, which have economic, technical, socio-cultural aspects and, in that connection, by the difficulty of bringing together representatives of different sciences. The article analyzes the origins of the formation of the theory of digital economy, the main approaches to determining the essence of the concept of “digital economy”, considers the complementary nature of the study of digital economy as a modern economic environment - a stage of the development of the information economy, and as a sphere of application of digital technologies. The author substantiates the opinion that in the context of the digital economy, bringing into line with the new realities of the content of university educational programs is of fundamental importance, since the formation of a digital literacy and economic way of thinking among future specialists as the basis for solving professional problems in the digital environment takes on special importance.
SCENARIOS OF THE INVESTOR’S EXIT FROM VENTURE INVESTMENTS
Authors: Voskanian R.O.
Published: May 2021

The subject of research is contractual relationships between the investor and the founders of a young company, which predetermine exit scenarios for the investor at different stages of the company's development. To identify the main scenarios of the investor's exit from venture capital investments, the author uses research methods such as synthesis and comparative analysis. Analysis of Russian and foreign scientific literature has revealed that the main focus is on the exit of a venture investor from a business, and insufficient attention is paid to the exit of a business angel. The article considers additional contract terms that are not widespread in Russia, but are used in practice in foreign countries, which regulate the exit of an investor from a business, namely "drag-along", "tag along" and "demand right". The advantages and disadvantages of the main scenarios of the investor's exit from a business for both sides of investment relations are determined. Based on the results of considering the main scenarios of investor’s exit from a business and the key risks characterizing them, the instrument of internal hedging against the risk of a radical change in the company's development strategy due to the change of investor has been determined - multi-voting shares. Founders and investors can use the results obtained in the study at the early stages of company's development.
Structure and signifi cance of cytogenetic abnormalities in patients with multiple myeloma
Authors: Abramova T. V. , Obukhova T. N. , Gribanova E. O. , Solovev M. V. , Firsova M. V. , Votyakova O. M. , Kulikov S. M. , Chabaeva Yu. A. , Gal’tseva I. V. , Mendeleeva L. P.
Published: May 2021

Introduction. Cytogenetic and genomic traits of tumour cells are considered the key mediating factors in multiple myeloma (MM). Selected chromosomal abnormalities are prognostic of therapeutic response and patient survival in MM.

Aim — to assess of the diversity and rate of chromosomal abnormalities in MM patients and their association with the disease course.

Materials and methods. The study enrolled 134 MM patients with pre-treatment bone marrow FISH assay screening for chromosomal abnormalities: t(11;14), t(4;14), t(14;16), t(14;20), t(6;14), hyperdiploidy, del13q14/-13, del17p13/TP53, amp1q21, t(8q24)/cMYC. The studied criteria at the MM onset were: hemogram, lactate dehydrogenase (LDH) activity, calcium, β2-microglobulin and creatinine concentrations, punctate cytology, bone marrow trephine biopsy and/or soft tissue biopsy histology, bone X-ray, immunochemical variant of MM, disease staging. A median follow-up was 20 months (3.2–77.4).

Results. The primary chromosomal abnormality rate was 82.9  %, among them t(14q32)/IGH  — 29.1  %, multiple trisomies — 46.3 % and their combination — 7.5 %. The rates of particular t(14q32)/IGH): t(11;14) — 16.4 %, t(4;14) — 12.7 %, t(14;16) and t(14;20) — 3.7 and 2.2 %, respectively. The secondary chromosomal abnormality rate was 69.4 %, among them del13q14/-13 — 40.3 %, amp1q21 — 39.6 %, t(8q24)/cMYC — 17.2 %, del17p13/TP53 — 12.7 %, del1p32 — 2.2 %. Analyses of the primary–secondary abnormality combinations showed that del13q14/-13 is more frequently combined with t(4;14) and less frequently with trisomies (p < 0.05). Amp1q21 occurs more frequently with t(4;14) and less — with t(11;14) (p<0.05). Patients with t(4;14) more frequently (p < 0.05) had anemia at a hemoglobin level<100 g/L, and the presence of amp1q21 and del17p13/TP53-enhanced serum LDH activity (p < 0.05). Abnormality t(8q24)/cMYC more often co-occurred with higher serum β2-microglobulin concentrations (p < 0.05). A three-year overall survival (OS) in del17p13/TP53-positive patients was 35.5 vs. 71.3 % in the negative (p = 0.002) and 50.8 vs. 67 % — in t(8q24)/cMYC-positive and negative patients, respectively (p = 0.001). Patients without amp1q21, with one, with two or more additional 1q21 copies had a five-year OS 79.4, 67.3 and 20.9 %, respectively (p = 0.0016), and a two-year progression-free survival (PFS) 83, 50 and 0 %, respectively (p = 0.005).

Conclusion. We establish a negative impact of del17p13/TP53 and t(8q24)/cMYC on patients’ OS in MM, as well as unfavourable effect of amp1q21 on OS and PFS in the presence of two or more additional copies of 1q21 loci.
Comparative characteristics of bone marrow cell composition, stroma, and trabecular bone in allogenic hematopoietic stem cell transplantation in patients with primary myelofibrosis
Authors: Chebotarev D. I. , Kovrigina A. M. , Melikyan A. L. , Kuzmina L. A.
Published: May 2021

Introduction. Primary myelofibrosis (PMF) is a clonal disease violating the cell composition, histological topography and stroma in bone marrow (BM). Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative therapy in PMF.

Aim — description of change in the haematopoietic tissue cell composition and stroma, as well as in trabecular bone in allo-HSCT patients with fibrotic PMF.

Materials and methods. We studies 24 trephine biopsy samples from nine PMF patients with allo-HSCT at the intervals: I — 1 month prior to, II — past 1–3 months and III — past 4–6 months from allo-HSCT. BM trephine biopsy slides were prepared in a standard histological assay with haematoxylin—eosin and additional staining with Gomori’s silver and Masson’s trichrome. Morphological change was evaluated in reticulin and collagen stroma, bone trabeculae, cellularity and topography of haematopoietic tissue.

Results. The BM trephine biopsies of interval I were morphologically distinguished in three types by haematopoietic cellularity, stromal and trabecular sclerotic change. Post-transplant intervals II and III (3–6 months after allo-HSCT) did not reveal these types but showed an evident myelofibrosis and osteosclerosis reduction and signs of a restoring bone remodelling cycle. Myelopoietic lineages recovered in stages: the erythroid germ restored in three, granulocytic — in six months, and megakaryocytic cellularity did not fully recover in six months. Myelopoietic cellularity recovery outpaced blood recovery, which may be due to induced myelodysplasia or disruption of stromal niches.

Conclusion. Allo-HSCT leads to the disappearance of PMF-pathognomonic BM morphology reflecting a histological remission. The reduction of myelofibrosis and osteosclerosis and normalisation of the trabecular bone remodelling cycle in post-transplant periods indicates an impact of cell microenvironment on PMF pathogenesis and warrants research into the composition and histological topography of cell microenvironment in PMF.
Exclusive Breastfeeding with the Incidence of Stunting in Toddlers
Authors: Rilyani Rilyani
Published: May 2021

Introduction; Short and very short, known as stunting, are nutritional status based on the height index for age. The purpose of knowing the relationship between exclusive breastfeeding and the incidence of stunting. Methodology; This study was conducted using analytic observations with a cross-sectional approach, the population in this study were all children under five in the working area of Puskesmas X, the number of samples used was 82. Results; showed that 18 children who were not stunting were given exclusive breastfeeding (52, 9%) Stunting of children under five who were given exclusive breastfeeding were 16 children (47.1%). As many as 12 children under five who were not stunting (25.0%) were not exclusively breastfed and as many as 36 children under stunting (75.0%) were not exclusively breastfed. Conclusion; There is a significant relationship between exclusive breastfeeding and the incidence of stunting in the working area of Puskesmas X Lampung Tengah
Ekstrak Pollen Kurma (Phoenix dactylifera L) Sebagai Terapi Infertilitas Pada Pria
Authors: Rahmadiani Devi
Published: May 2021

Pengantar; Infertilitas merupakan salah satu masalah yang dihadapi pasangan yang ingin memiliki keturunan. Infertilitas dalam setahun terjadi sebanyak 15% pada pasangan yang mengharapkan kehamilan. Tujuan; menganalisis bahwa kandungan antioksidan pada DPP dapat menangkal radikal bebas dan mencegah terjadinya stress oksidatif. Metode; analisis dilakukan dengan metode systematic literature review dengan menelaah, mengidentifikasi, mengkaji, dan menyajikannya. Hasil; ditemukan berbagai penelitian yang menunjukkan bahwa ekstrak DPP memiliki efek untuk mencegah dan mengobati kemandulan. Kesimpulan; bahwa adanya penurunan kualitas sperma akibat peningkatan stress oksidatif akibat ketidakseimbangan antioksidan dan radikal bebas
Effect of electrochemical functionalization of single-walled carbon nanotube electrodes in flexible enzymatic biofuel cells
Authors: Momaya Divyang , Ohno Yutaka
Published: May 2021

We report a flexible enzymatic biofuel cell based on electrochemically functionalized single-walled carbon nanotube (SWNT) electrodes. Comparative studies on the impact of the electrochemical functionalization of the SWNT electrodes on the device performance revealed a 40%–110% increase in power density as compared to that of the device with as-fabricated SWNT electrodes, with an observed maximum power density of 7.2 μW cm−2. This improvement in performance can be attributed to the increase in the amount of enzymes adsorbed on the SWNT surface and the enhanced electron transfer rate owing to the SWNT functionalization. Our findings can aid improve the performance of flexible and high-power-density biofuel cells.
Spatial structure of Globularia bisnagarica L. (Plantaginaceae, Magnoliopsida) coenopopulations
Authors: Kondratieva A. O. , Parkhomenko A. S. , Bogoslov A. V. , Shilova I. V. , Kashin A. S.
Published: May 2021

The paper presents the results of the spatial distribution analysis of 18 Globularia bisnagarica L. coenopopulations in the Saratov, Samara, Ulyanovsk and Orenburg regions and the Republic of Tatarstan. The analysis was carried out with the Spatstat package of the R environment for statistical computing. The research reveals an aggregation tendency for the G. bisnagarica coenopopulations. It is suggested that this tendency may be attributed to the prevalence of seed reproduction and certain peculiarities of dissemination (barochory) in the studied coenopopulations as well as to the confinement of the species to eroded landforms (slopes of watersheds, gullies, runoff hollows, etc.) characterized by high heterogeneity of environmental conditions. It has been established that the majority of G. bisnagarica coenopopulations grow in heavily or moderately sodded habitats. Nevertheless, in the studied communities, G. bisnagarica occurs abundantly and dominates along with Stipa pennata, Bromus inermis, Salvia nutans, Elytrigia repens, Poa compressa, etc. Finally, the spatial structure of G. bisnagarica coenopopulations is impacted by the interspecific competition in calciphilous phytocenoses under the invasion of eurybiontic steppe grasses.
STATE REGULATION OF RURAL AREAS DEVELOPMENT IN UKRAINE
Authors: Berezivskyy Zinoviy , Berezivska Oksana
Published: May 2021

Theoretical bases and methodical approaches to the study of state regulation of rural development in Ukraine are substantiated and the main tendencies of changes for the future are revealed. Many of the problems associated with rural development remain unexplored and need to be further addressed. This confirms the relevance, novelty and expediency of scientific research of the outlined problem. The method of research of state regulation of rural development is described, which is based on the use of methods necessary to establish the relationship between factors and results. In order to establish effective state regulation of rural development, the directions of further reforming the system of state regulation of rural development are proposed.
МОДИФІКОВАНИЙ РЕГУЛЯТОР ОБЕРТІВ БЕЗКОЛЕКТОРНОГО БЕЗДАТЧИКОВОГО ЕЛЕКТРОДВИГУНА
Authors: Шліхта Олександр , Губар Вячеслав
Published: May 2021

Електронний регулятор швидкості (Electronic speed control)[1] - це електронна схема, яка керує та регулює швидкість електродвигуна. В ході розробки було досліджено рішення на ринку та проведено їх аналіз. Основні недоліки полягають у тому, що наявні регулятори обертів для модельних електродвигунів не мають вбудованого захисту від неправильного підключення джерела живлення на вході, а також не відслідковують струм, що споживається електродвигуном. Недоліки було усунуто шляхом додавання в регулятор схеми захисту від переполюсування на основі польового транзистору і датчику струму на ефекті Холла. В підсумку було отримано модель регулятора, що значно більш практичний за наявні рішення.
ПРОЦЕС МАРКОВСЬКОГО ВІДНОВЛЕННЯ ДЛЯ СИСТЕМИ МАСОВОГО ОБСЛУГОВУВАННЯ ТИПУ M/Gi/2/0
Authors: Літвін Наталя
Published: May 2021

В роботі побудовано процес марковського відновлення (ПМВ) для двоканальноїсистеми масового обслуговування типу M/Gi/2/0. Для досягнення мети простір фізичнихстанів системи розширений до фазового простору полумарковських станів, визначенічаси перебування системи в станах, знайдені перехідні ймовірності.
FRANSUZ MATBUOTIDA FRAZEOLOGIK BIRLIKLARNING ISHLATILISHI
Authors: Isroilova Manzura
Published: May 2021

Phraseology is the focus of many linguists, and scholars who have studied the field have differing views on phraseological units. Phraseology is the study of set or fixed expressions, such as idioms, phrasal verbs, and other types of multi-word lexical units , in which the component parts of the expression take on a meaning more specific than or otherwise not predictable from the sum of their meanings when used independently. This article focuses on the semantic-pragmatic analysis of phraseological units commonly used in the French press.
ПРО КОНКУРЕНЦІЮ СВІТОГЛЯДІВ У СИСТЕМІ ОСВІТИ УКРАЇНИ
Authors: Кірик Тамара
Published: May 2021

До накопичених в Україні за роки невдалих реформ численних негараздів додався прихід пандемії COVID-2019, що значно ускладнило діяльність всієї національної системи освіти. У спілкуванні зі студентами ми формуємо у них фахову компетентність та спроможності захисту від консцієнтальних нападів і негативного впливу ЗМІ. Серед найкращих засобів — застосування удосконаленої філософії освіти і перспективної світоглядної парадигми з назвою «ноогуманізм». У статті досліджено можливу роль термінів з префіксом «ноо» і наведено авторський варіант ноолексикону. Необхідно скерувати вищу школу України на розвиток ноонаук і підготовку студентів до участі в побудові ноосуспільства. Час відмовитися від старих стандартів досконалості й оцінювати якість вищої освіти за вимогами ХХІ століття.
À PROPOS DU POTENTIEL DIDACTIQUE DE LA BANDE DESSINEE AU COURS DU FRANÇAIS LANGUE ETRANGERE
Authors: Halazdra Svitlana
Published: May 2021

Pendant longtemps, la bande dessinée a été considérée comme une "lecture facile", qui ne méritait pas l'attention ni des scientifiques ni des éducateurs. Aujourd'hui, la situation a beaucoup changé: la bande dessinée est entrée dans notre vie à la fois comme genre de littérature et comme forme d'art moderne. Dans cette étude, la bande dessinée agit comme un moyen d'améliorer la compétence communicative en français comme langue étrangère des étudiants. On propose plusieurs varientes du travail avec les bandes dessinées aux cours de français, on donne une justification linguodidactique de l'utilisation de la bande dessinée dans l'enseignement du français.
РЕЗУЛЬТАТИ ВИБОРЧОЇ КАМПАНІЇ ДО КАТЕРИНОСЛАВСЬКОЇ МІСЬКОЇ ДУМИ В СЕРПНІ 1917 Р.
Authors: Яценко Віталій
Published: May 2021

У статті проаналізовані результати виборів до міської думи Катеринослава влітку 1917 р. Розкрито процес формування кандидатських списків та визначено їх партійну приналежність. Охарактеризовано розподіл голосів місцевого електорату та його партійно-політичні симпатії щодо учасників передвиборчих перегонів. Дана оцінка розподілу партійних сил у новообраній думі, названі сформовані при цьому центри сили.
СЦЕНІЧНО-РЕЖИСЕРСЬКА ОСВІТА: ІСТОРИЧНІ ВИТОКИ ТА ШЛЯХИ АДАПТАЦІЇ В СУЧАСНИХ УМОВАХ
Authors: Приз Валерія
Published: May 2021

Викладений матеріал проводить порівняння між освітніми тенденціями у режисурі на початку її становлення у ХХ столітті та сьогоденням. У статті приділяється увага першим навчальним закладам та компетенціям, які вони формували відповідно до історичних умов. Також розглянуті деякі проблеми сценічної освіти у контексті Болонського процесу та їх співвідношення з історично сформованим досвідом у викладанні режисерської майстерності.
Superior Cluneal Neuralgia from Iliocostal Impingement Treated with Phenol Neurolysis: A Case Report
Authors: McAnally Heath
Published: May 2021

Background: Superior cluneal neuralgia (SCN) is an increasingly recognized yet still frequently overlooked cause of chronic lumbosacral and buttock pain. While historically attributed generally to iatrogenic iliac crest injury (bone marrow biopsy or bone graft harvest), more recently it is recognized as occurring in the absence of any trauma, with idiopathic entrapment resulting in compression neuropathy. Iliocostal impingement syndrome (IIS) is an even less commonly considered condition whereby the lower costal margin repetitively contacts and irritates the iliac crest, primarily occurring unilaterally and owing to severe scoliosis, but also in the context of severe vertebral column height loss.
Case Report: We report here a case of an elderly woman with a 3-inch reported height loss over the decades who had suffered with chronic and intractable right lumbosacral and gluteal pain, and whom, on the basis of physical examination, we diagnosed presumptively with both SCN and with IIS as the underlying pathophysiologic mechanism. After undergoing successful diagnostic fluoroscopically guided superior cluneal nerve block, she was offered phenol denervation and enjoyed 9 months of reported 90% improvement in her symptoms, with gradual return to baseline over the next couple months. She has subsequently undergone repeat phenol denervation twice, with similarly good results. We believe this to be the first documented application of phenol neurolytic technique to SCN, and in the case of iliocostal impingement we argue that surgical release/resection or even peripheral nerve stimulation may not be effective owing to underlying compression/irritation diathesis from the inevitable pressure of the costal margin upon the iliac crest.
Conclusion: In this case report, we also briefly summarize the current literature on SCN and compare phenol neurolysis to other therapeutic modalities.
Key words: Superior cluneal nerves, neuralgia, iliocostal impingement, phenol, denervation
Case Report: Postherniorrhaphy Pain from Muscle Calcification
Authors: Koushik Sarang
Published: May 2021

Background: Inguinal hernia repair is a commonly performed surgical procedure. Surgical repair is a widely accepted treatment option as a corrective measure for inguinal hernias, but it is not without its potential for complications, including chronic postinguinal herniorrhaphy pain. Neuropathic pain, which is the result of nerve damage during inguinal herniorrhaphy, can be caused by compression, irritation, or entrapment by sutures, staples, mesh, tacks, or prosthetic material. It can also occur secondary to periosteal reactions or by actual nerve injuries, such as neurapraxia, axonotmesis, neurotmesis, or complete transection, which can cause end neuroma formation and pain. Nociceptive pain, however, can occur as a result of inflammatory changes at the surgical site leading to chronic pain. Foreign bodies, such as mesh, sutures, and staples, are all possible triggers for the inflammatory reaction.
Case Report: Ultrasound (US) is a noninvasive and affordable diagnostic tool that showed benefit in identifying dystrophic calcification as a potential cause for postinguinal herniorrhaphy chronic pain. It is also used to successfully guide the administration of local pharmacologic agents to control this pain. Use of US in this case allowed us to detect the densely calcified part of the abdominal wall muscles as a hyperechoic area at the surgical bed. The ability of US to detect calcification is not limited to macroscopic calcification only. It was also found to be useful in early detection of microscopic calcification in certain musculoskeletal conditions.
Conclusion: We suggest that US should be considered routinely in the evaluation of cases of postinguinal herniorrhaphy chronic pain.
Key words: Postherniorrhaphy pain, neuropathic pain, muscle calcification, radiofrequency ablation, ultrasound
A Case Report of Successful
High-Frequency 10-kHz Spinal Cord
Stimulator Trial in a Patient with
Refractory Thoracic Postherpetic
Neuralgia
Authors: Alla Sai P.
Published: May 2021

Background: Spinal cord stimulation can be an effective treatment modality in patients suffering from postherpetic
neuralgia who have failed first-line pharmacotherapy and continue to struggle from debilitating pain.
Appropriate patient selection and having a wide array of stimulation waveforms can enhance the success
of spinal cord stimulator trials.
Case Report: In this article, we present a case report of a patient suffering from refractory thoracic postherpetic neuralgia
who underwent a successful high-frequency 10-kHz spinal cord stimulator trial. Lead tips were
successfully placed at the midline and left paramedial side of the top of T1 vertebral bodies at the source
of the pain. The patient was followed up in our clinic 7 days post procedure. At the time of follow-up,
our patient reported an 85% to 90% reduction in his pain symptom scores and a significant improvement
in his quality of life.
Conclusion: Similar successful trials for postherpetic neuralgia have been reported in small studies using traditional
low-frequency stimulation waveforms. However, to our knowledge, this is the first report of a successful
spinal cord stimulator trial using high-density 10 kHz.
Key words: Postherpetic neuralgia, high-frequency spinal cord stimulator, acute herpes zoster
A COMPARATIVE STUDY OF LEVELS OF HIGH SENSITIVITY CREACTIVE PROTEIN (hs-CRP) IN DIABETIC AND NON- DIABETIC POPULATION OF CENTRAL INDIA
Authors: Gupta Parag , Singh Lal Pranay
Published: May 2021

Background: Diabetes mellitus is the most common metabolic disorder characterized by metabolic abnormalities and
long term complications. It is characterized by hyperglycemia resulting from defect in insulin secretion and in its action. It
has become a leading cause of morbidity and mortality world over. hs- CRP is a marker of low-grade inammation and it is raised in patients with
type 2 DM. The present study was undertaken with the objective of studying the relation of High Sensitivity CRP (hs-CRP) in patients of type 2
Diabetes Mellitus and in non-diseased population. Methods: This was a comparative observational study, conducted at Diabetic clinic, Index
Medical College, Indore during August 2014 to July 2015. Cases and control were selected as per the inclusion criteria. Statistical analysis was
done using SPSS v20. Mean age of the group was 48years. The mean hs CRP in the diabe Results: tic group was 0.45 compared with 0.35, in the
control group. hs CRP levels are directly related to insulin resistance and is Conclusion: highly associated with diabetic population.
CLINICAL PROFILE OF YOUNG ADULTS (18-24 YEARS) WITH POLYCYSTIC OVARY SYNDROME
Authors: Balakrishnan Sheila , Nair MKC , George Babu , L Jaysree , ML Leena
Published: May 2021

Background: Polycystic Ovary Syndrome is a common endocrine problem with a heterogenous clinical picture. Early
identication is essential to prevent metabolic problems and infertility. To estimate the prevalence of Objective:
Polycystic Ovary Syndrome and depict the clinical prole of young adults (18-24 years) with Polycystic Ovary syndrome. A cross- Methods:
sectional study of all the nursing students aged 18-24 years in Thiruvananthapuram District was conducted to self-screen for Polycystic Ovary
Syndrome and Rotterdam criteria were applied. The study group comprised 529 subjects who were diagnosed to have the syndrome. The clinical
and ultrasonographic characteristics and anthropometric variables of the study group were estimated and compared with 399 young adults
without Polycystic Ovary Syndrome. Variables were expressed in terms of frequenci Statistical Analyses: es for categorical and mean (± SD) for
continuous variables. Chi-square test was used for categorical and t- test for continuous variables. The prevalence of Polycystic Ovary Results:
Syndrome was 13.1%. Irregular periods was seen in 74.7%, hirsutism in 57.1%, acne in 37.1%, acanthosis nigricans in 51% and alopecia in 2.5%.
Overweight and obesity were found in 30.8%, increased waist circumference in 16.1% and hypertension in 27.8%. Polycystic Conclusion:
Ovary Syndrome is a clinically heterogenous condition with an increased prevalence of irregular periods, hirsutism, acne and acanthosis.
Overweight and obesity are signicantly increased. A younger age group of late adolescents or young adults is ideal to screen for the syndrome
and institute lifestyle intervention to prevent metabolic problems.
RESISTANT MULTIDROUGH TUBERCULOSIS: DETERMINANT AND CONTRIBUTING FACTORS OF PATIENTS IN THE CITY OF NOVA IGUAÇU
Authors: Conceição Marilene da , Naves Alves Ana Lucia , Nacif Lube Paulo Alex , da Silva Fabiola Soares , dos Santos Elaine Alves , da Conceição Silva Amanda Machado , Florêncio Cássio do Nascimento , Lima de Sousa Carlos Eduardo Abreu , Carvalho Luciana de , Gonçalves Jane Peçanha
Published: May 2021

Objectives: to outline the socio-demographic prole of Multidrug Resistant Tuberculosis (TBMR) in the municipality of
Nova Iguaçu from 2015 to 2017; correlate determining factors and contributors to Multidrug Tuberculosis in Nova
Iguaçu residents from the same period; to identify the diseases associated with Multidrug Resistant Tuberculosis in the residents of Nova Iguaçu,
in the period from 2015 to 2017. Qualitative, descriptive, retrospective study, being a source of re Methods: search on TBMR patient records,
notication forms and DATASUS data in the period of 2015 to 2017, regardless of the outcome, through an instrument prepared by the authors.
Research eld was the Municipal Tuberculosis Control Program (PMCT) of that city from the same period. In the analysis, a database was built in
an Excel 2010 spreadsheet with the collected variables, using absolute and relative frequency. We found 36 cases (73.47%) of primary Results:
resistance and 13 (26.53%) of acquired resistance (AR), with an average of ± 1.4 previous treatments. There was cure in 19 cases (38.8%),
abandonment in 11 (22.4%) and death in 3 (6.1%), 6 (12.2%) cases of bankruptcy and 10 (20.41%) complete treatment; and the associated
comorbidities stood out HIV, smoking and Diabetes Melitus. We know that in order to reduce a disease Conclusion: , we need prevention and
public policies for it, and that people understand and incorporate it into their routine.
ASSESSMENT OF PULMONARY STATUS FOLLOWING INTERMAXILLARY FIXATION- A CLINICAL STUDY
Authors: John Bobby , Poorna T Anish , K Sandhya , EK Joshna
Published: May 2021

Aim: The aim of the study was to determine the effect of intermaxillary xation on pulmonary function. Methods:133 patients comprising 107 males and 26 females with age ranging from 18 to 50 were taken up for study. The patients' Pulmonary Function Tests were done using spirometer to measure the necessary parameters before and after the application of intermaxillary xation. The values obtained were also compared with 50 healthy volunteers. Results: The results showed that there is a signicant decrease in values of Pulmonary Function Test after the application of intermaxillary xation. Conclusion: Pulmonary status evaluation becomes necessary on account of the obstructive nature of intermaxillary xation. This simple and routinely used procedure should be avoided in respiratory compromised patients with Pulmonary Function Test values lower than the predicted value.
ROLE OF PLATELET PARAMETERS IN DENGUE FEVER IN CHILDREN
Authors: Kumar Mithilesh , Sinha R. K. , Jana Debarshi
Published: May 2021

Aim: To evaluate the role of platelet parameters in dengue fever and also to determine relationship of platelet parameters
with platelet count and the severity of the disease. The platelet para Materials and methods: meters [platelet count,
plateletcrit, mean platelet volume (MPV), platelet distribution width (PDW)] of 50 dengue infected children were calculated using BC 3000 plus
Mindray Automated Hematology Analyzer. Normal range of MPV is 7.5-11.5 . Plateletcrit cut off value in thrombocytopenia is 0.2-0.36%. The
PDW reported varies with reference intervals ranging from 8.3 to 56.6%. Subjects were divided into four groups according to their platelet count
on day 3 of illness (<20,000 cells/cumm, 20,000 to 50,000 cells/cumm, 50,000 to 100,000 cells/cumm and >100,000 cells/cumm). Platelet
indices were studied among these groups and also the indices were evaluated with respect to the severity of disease as group A (dengue without
warning signs), group B (dengue with warning signs and group C (severe dengue). Results: Male: female ratio was 28:22. Mean age of
presentation was 7.8 + 2.2 years. Thirty-ve patients belonged to Group A, 26 to group B and 2 belonged to group C. PLT (cells/cumm) on Day 3
and Day 7 was 91,828 ±33,532 vs 195,371 + 70,586 in Group A patients (p<0.0001), 69,076 ±45,904 vs 163,230 + 85,053 in Group B patients
(p=0.0018) 38,500 + 38,890 vs 86,000 + 28,284 in Group C patients (p=0.29). PCT (%) on Day 3 and Day 7 was 0.09 + 0.04 vs 0.18 + 0.06 in
Group A patients (p<0.0001), 0.07 + 0.04 vs 0.15 + 0.07 in Group B patients (p=0.0009) and 0.04 + 0.04 vs 0.08 + 0.28 in Group C patients
(p=0.84). MPV () on Day 3 and Day 7 was 10.73 + 1.07 vs 11.34 + 1.09 in Group A patients (p=0.0212), 10.41 + 1.39 vs 10.87 + 0.99 in Group B
patients (p=0.3389), 9.35 + 1.62 vs 10.3±1.41 in Group C patients (p=0.59). PDW () on Day 3 and Day 7 was 14.46 ± 1.35 vs 13.22 + 1.10 in
Group A patients (p=0.0001), 14.61 + 1.36 vs 13.0 + 0.76 in Group B patients (p=0.0011) and 14.5 + 1.84 vs 13.5 + 0.71 in Group C (p=0.54).
Though MPV was lower in patients with platelet count <20,000 cells/cumm (8.57 + 0.5 ) as compared to other groups, it was not statistically
signicant (p=0.325). PCT increases with increase in platelet count on Day 3 and Day 7 (p=0.000). Though PDW was lower on Day 3 in patients
with platelet count <20,000 cells/cumm as compared to the other 3 groups, it was not statistically signicant (p=0.0740). Conclusion: Lower
platelet count and low PCT are seen with severe dengue, increasing platelet count and PCT suggest recovery phase of dengue. MPV had no
correlation with severity of dengue or level of thrombocytopenia suggestive that there is no role to predict severity of dengue. PDW does not
uctuate with severity of dengue or level of thrombocytopenia
STUDY OF HYPOGLYCEMIA IN BREASTFED LATE PRETERM NEONATES
Authors: Kumar Mithilesh , Sinha R. K. , Jana Debarshi
Published: May 2021

Background: Aim: To evaluate the usefulness of regular monitoring of blood glucose in early diagnosis of hypoglycemia in breastfed late preterm neonate. A total of 100 consecutively born bre Methods: astfed late preterm neonates were studied and assessed for development of hypoglycemia against age of onset, symptomatology, gestational age and sex of the baby, parity and age of mother, and mode of delivery. Serial blood glucose was done at 0, 1, 3, 6, 12, 24, 48 and 72 hours of life to identify hypoglycemia. Blood glucose was estimated from heel prick capillary samples using glucometer. Association of both maternal and neonatal risk factors was studied in relation to hypoglycemia. The overall incidence of hypoglycemia was 15%. O Results: ut of 15 hypoglycemic babies 12(80%) developed symptoms and only 3(20%) were asymptomatic. Most (90%) of the hypoglycemia occurred on the rst day of life. Babies born to primi mothers were more prone for hypoglycemia (25%). Highest incidence was seen in babies weighing less than 2 kg (50%). Symptoms of hypoglycemia included poor feeding (66%), lethargy (58%), jitteriness (41%), and weak cry (25%). Th Conclusion: ere is a signicant incidence of hypoglycemia in late preterm babies in spite of being on breast feeds. Babies born to primiparous mothers are more prone for hypoglycemia. Also hypoglycemia was very high in babies having birth weight below 2 kg. Therefore it is very important to regularly monitor the blood glucose levels in all late preterm babies even if they are on exclusive breast feeding.
COLLAGEN BIOSTIMULATOR WITH POLYMETHYLMETHACRYLATE
Authors: Bortolozo Fernanda , Menezes Honorio Sampaio , Dias Alves Danuza , Mafaldo Rodrigo Cadore , Chacur Roberto , da Silva Chacur Nívea Maria Bordin , Gomes Leando Dias , Nardi Raissa , Marchesin de Castro Gabriella Andressa
Published: May 2021

Introduction: Polymethylmethacrylate (PMMA) is a potent agent that induces neocolagenesis and neoangiogenesis
when used in dermal and subcutaneous tissue implantation techniques. In this study, the collagen biostimulation
technique with PMMA is presented, with adequate and safe concentrations for facial lifting in different laxity degrees. To present the Objective:
PMMA using technique in collagen´s face biostimulation. Material (PMMA) Methods: characteristics, concentrations, suspension technique,
injection technique, areas subject to treatment, risk areas and post-treatment assessment in several facial laxity degrees were described.
Conclusion: This study described the particularities of the use of PMMA as an effective and potent biostimulator. The technique proved to be
effective in treating varying degrees of facial laxity.
CONCEPT OF VESHTAN CHIKITSA BY AACHARYA VAGBHAT WITH ITS CHIKITSA ASPECT.
Authors: Shendye Hemangi V. , Kulkarni Sachin S. , Asutkar Vasudha
Published: May 2021

Due to unhealthy or inappropriate lifestyle, vitiation of Vata Dosha is mainly observed in patients. Acharya Vagbhat in
Sutrasthan, has advised specic Viharaj Chikitsa i.e., external application as a part of treatment for each Dosha. Ayurved is
known as 'Science of Life', as Vyadhi Shaman is one of the aims of Ayurved. Different Viharaj Chikitsa like Veshtan Chikitsa plays important role
in treatment of diseases. In Samhita, applied aspect of Veshtan as Viharaj Chikitsa Upakrama is described widely. In this article, probable mode of
action of Veshtan which is main Viharaj Chikitsa for Vata Dosha along with its therapeutic uses is explained. Veshtan as a treatment is essential
mainly for extermination of the diseases which are caused due to Vata Dosha and also essential for diseases where Vata Dosha is vitiated.
Tcs evolution of CICC during Testing
Authors: Kaverin Denis
Published: May 2021

139 conductors were manufactured for the magnetic system of the ITER toroidal field coils in total by 6 different teams based on 5 different suppliers of Nb3Sn wires. Despite the fact that all conductors and superconducting wires were manufactured according to the same criteria, there were some differences in the manufacturing technologies of the components themselves, and in the result of the acceptance tests. Samples of some of the conductors passed acceptance tests, where the dependence of Tcs on the number of cycles of inputting the operating current into the samples when they were in a magnetic field was determined. The results of these tests showed that there are not only quantitative, but also qualitative differences in the Tcs (N) dependence. These differences are also observed within the same supplier. It would be useful to understand which parameters most strongly contribute to Tcs (N) in order to possibly improve this characteristic. For this purpose, the article provides a statistical analysis of the test results of 49 samples of conductors. The results are being discussed.
1, 1000, 100.000. Quanti e quali attori nei costrutti personali indeterminati?
Authors: Fici Francesca , Žukova Natalia
Published: May 2021

The aim of this article is to suggest a reflection on the indefinite-personal sentences of Russian. After a discussion of the properties of these sentences (1), we consider the grammatical and semantic characteristics of their components and especially of the null subject (2). In section (3) we consider which verbs occur more frequently in these sentences and in (4) the relationship among the different components of the indefinite-personal sentences. In (5) we conclude by briefly introducing the Italian sentences that most frequently correspond to Russian sentences of this type.
Ограничительные факторы синтаксических трансформаций русских идиом
Authors: Gasanova Mijat Marina
Published: May 2021

This paper attempts to identify the factors that either limit the passivization and decausation of Russian idioms containing transitive verbs of movement. Most of these verbs are highly subject to passivization in free structures and produce causative-decausative pairs. But in phraseological units their transformation is not always possible. The purpose of this research is to reveal the semantic and grammatical features that restrict the above transformations, to identify their primary or auxiliary role and to determine the existence of common features that resist both types of transformation.
Il suffisso verbale -yva-/-iva- in testi slavo-orientali dei secoli XI-XIV
Authors: Ruvoletto Luisa
Published: May 2021

The article focuses on the main uses of secondary imperfective verbs with the suffix -yva-/-iva- in Early East Slavic texts dated 11th-14th centuries. The verbs with this suffix are used in all different contexts where the imperfective verbal aspect is required. The examples from the texts show a more frequent occurrence of the verbal forms with the suffix in dialogues, that is in passages involving oral communication contexts. Only in the later centuries the suffix will also take the particular function of expressing the “iterative mode of action” (iterativnyj sposob dejstvija).
Meaning Relationship of the Verb Hope and Wish in English
Authors: Maretha Carla
Published: May 2021

This research is qualitative which aims to describe grammatical form of wish and hope, to classify elements of wish and hope sentences, and to analyse meaning of both words based on meaning tendency of grammatical form and elements. This research uses British National Corpus as data source, then the data are presented informally. This research shows that hope and wish have the same 5 grammatical forms, but hope and wish cannot be used interchangeable for having different tendency. Hope and wish can be synonymous conceptually, but characteristically they cannot be (real-unreal, and desired-wanted).
SÍNDROME DE BURNOUT E O TRABALHO DOCENTE: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Stasiak Priscila , Pedroso Bruno , Freitas Júnior Miguel Archanjo de , Carmo Gonçalo Cassins Moreira do , Fujinaga Cristina Ide
Published: May 2021

O presente estudo objetivou verificar as publicações nacionais que investigaram a Síndrome de Burnout entre professores. Para isso, as perguntas norteadoras do estudo foram: “qual a prevalência da síndrome de Burnout entre os professores brasileiros?”; e “quais são os principais fatores precipitadores da Burnout entre estes docentes?”. A revisão integrativa foi realizada com base em pesquisas nos bancos de dados Scopus e Portal de Periódicos da Capes. Dentro dos bancos de dados, foram consultados artigos publicados no período de 2014 a 2018, mediante o cruzamento das expressões: “Burnout”, “teacher”, “síndrome do esgotamento profissional”, “professor” e “docente”. Dentre os artigos encontrados, 13 deles preencheram devidamente os critérios de inclusão para o estudo. A partir disso, observou-se a presença de Burnout entre professores na maioria dos estudos analisados, indicando que estes profissionais constituem um grupo vulnerável para o desenvolvimento da síndrome. Os resultados apontam fatores relativos às condições e organização do trabalho, assim como conflitos interpessoais como fatores de risco para o processo de Burnout. Diante deste quadro, concluiu-se a necessidade de serem desenvolvidas ações voltadas à humanização da situação de trabalho que auxiliem na minimização da evolução do esgotamento profissional.
Estimación del Coeficiente de Gini utilizando Distribuciones Tipo Fase
Authors: Rodríguez Esparza Luz Judith
Published: May 2021

En este trabajo, se considera una nueva metodología para estimar el coeficiente de Gini utilizando las distribuciones tipo fase, en particular, utilizando las distribuciones de momento tipo fase. Para estimar dicho coeficiente, primero se obtienen los estimadores de máxima verosimilitud de las distribuciones tipo fase utilizando el algoritmo EM, para así después utilizar las distribuciones de momentos y obtener el coeficiente de Gini. Ilustramos la eficiencia del método propuesto calculando el coeficiente de Gini de México considerando tres años: 1995, 2000 y 2005.
Intervención didáctica para el aprendizaje de números complejos en modalidad virtual
Authors: Romero Robles Daniela , Quiñonez Ayala Mario Alberto , Del Castillo Bojorquez Ana Guadalupe
Published: May 2021

El presente reporte de intervención didáctica expone los resultados de la adaptación e implementación de una secuencia de actividades didácticas sobre el tema de números complejos que se ajustó a necesidades de la modalidad virtual, y que había sido trabajada previamente en un modelo presencial. Las actividades se llevaron a cabo en un curso de Álgebra con dos grupos de estudiantes de primer semestre de ingeniería de la Universidad de Sonora. Los análisis y resultados presentados se fundamentan teóricamente en el Enfoque Ontosemiótico del Conocimiento y la Instrucción Matemáticos, haciendo uso de las nociones de sistemas de prácticas, conflictos semióticos e idoneidad didáctica. Asimismo, se resaltan los beneficios y áreas de oportunidad sobre las implementaciones presencial y virtual, con la intención de brindar elementos que permitan incorporar adecuaciones a la propuesta, para un posible trabajo híbrido, en experiencias posteriores.
Estudio histórico de evaluación: Cumplimiento de metas de la Secretaría de Hacienda, Secretaría de Economia y Secretaría de Desarrollo Social del Estado de Sonora , del ejercicio 2015
Authors: Villa Ruiz Nallely Esther
Published: May 2021

En este artículo se realizara un estudio histórico del año 2015, para ello recurrimos a la información programática de la cuenta pública del poder ejecutivo de 2015, se tomaron como muestra de estudio 3 dependencias: la Secretaría de Hacienda, la Secretaría de Economía y la Secretaría de Desarrollo Social. Este análisis se realiza con el objetivo de Evaluar los programas públicos y lo indicadores para saber si las dependencias están cumpliendo las metas establecidas. En este análisis podemos observar cómo se distribuye el presupuesto del poder ejecutivo a las Dependencias del sector Público, y como éstas, crean programas en relación a dicho presupuesto con la implementación de objetivos para cumplimento de metas y los diversos indicadores de evaluación para cada programa. El Ejecutivo del Estado es el que logró cumplir un mayor porcentaje de metas con un 78% equivalente a 29. En total el Poder Ejecutivo estableció 477 metas. La Secretaría de Agricultura, Ganadería, Recursos Hidráulicos, Pesca y Acuacultura, es la Dependencia con menor porcentaje de metas cumplidas apenas alcanzó el 37% de ellas. En este análisis encontramos algunas metas inconclusas y deficiencias en los indicadores de los programas. Algunos de éstos programas no fueron efectuados, debido a cancelaciones de recursos por parte de la Secretaría de Hacienda, sin quedar claro a donde se redistribuyó dicho recurso. Aunado a esto los subejercicios registrados son de especial observancia, puesto que la sociedad siempre tendrá necesidades ilimitadas que cubrir, y se ve limitada de dicho recurso presupuestario.
Exclusión, discriminación y violencia: tres conceptos para reflexionar
Authors: Carrazco Valenzuela Ma. Engracia , Ruiz Hernández María de los Ángeles
Published: May 2021

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Entre pares soluciones integrales
Authors: Arenas Hinojosa María Clarissa
Published: May 2021

El proyecto de vinculación Entre pares soluciones integrales (EPSI), ha logrado consolidar al Centro de Bachillerato Tecnológico Agropecuario de Hermosillo (CBTA) 264, como una unidad académica receptora. Primeramente, ha permitido que el perfil de egreso de las estudiantes de trabajo social desarrolle estrategias didácticas innovadoras que promuevan y accedan al análisis y la reflexión, a partir de experiencias vividas por los propios actores sociales de la comunidad estudiantil. En segundo, EPSI ha facilitado concretar y visibilizar el proyecto de vinculación y extensión universitaria firmada entre la Universidad de Sonora y el CBTA 264. El curso taller se ha replicado en dos ocasiones y en ambos casos se retoman argumentos de convivencia, participación incluyente y habilidades para la vida; toda vez que se parte del concepto base de la educación como núcleo edificador de saberes y experiencias altamente significativas. EPSI está diseñado para reconocer los intereses de la comunidad educativa, incluyendo a los y las estudiantes, los docentes, los padres de familia, así como otros actores sociales involucrados e impactados por la labor académica. El objetivo final de EPSI es sumar esfuerzos para formar personas en la labor del autoconocimiento y reconocimiento de distintas vivencias y experiencias formativas: se fortalece así el trabajo colaborativo a fin de asumir una actitud de respeto e inclusión entre pares, docentes y comunidad.