bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategic management of creative industries: A case study of university information institutions
Authors: Bugrov Volodymyr , W. Sitnicki Maksym , Serbin Oleh
Published: July 2021

The purpose of this paper is to summarize the experience of leading university libraries in attracting and using creative industries implementating strategic management. The study was conducted taking into account the previous experience by analyzing and systematizing the regulatory framework, information, and analytical materials on this issue, and conducting personal interviews with librarians. The results and conclusions were obtained on the example of libraries of seven higher educational institutions of Ukraine, which are included in the QS World University Rankings and the Times Higher Education.The paper illustrates an extremely unsatisfactory financial situation and insufficient funding for university libraries. But even in such conditions, they are transformed into informational institutions, which not only provide users with a comfortable educational space but also produce innovative information resources and implement creative projects. The most significant projects are analyzed. All seven libraries have development strategies in which their mission is formalized. In three strategies there are no quantitative guidelines for development and, accordingly, the timing of their achievement. In addition, three strategies do not have the understanding of the need for business activities, and their key business processes are not clearly defined. Another three university libraries lack significant international creative projects. Instead, all seven university libraries recognize the need for creative industries and successfully implement creative projects of national importance.The study emphasizes the need to apply a model of strategic management of creative industries on the example of university libraries.
AcknowledgmentThis scientific paper published with support by British Council’s ‘Creative Spark: Higher Education Enterprise Programme’, project № 5742783597 – the ‘National Сentre for Сreative Entrepreneurship Development’ (NCCE).
Institutional Factors Affecting Retention of HIV Patient on Treatment at Wuse General Hospital, Abuja, Nigeria
Authors: Ado Uba Sabo
Published: July 2021

Retention On Treatment Is A Critical Factor In Reducing HIV-Related Morbidity And Mortality, The Incidence Of New Infections, And Development Of Drug Resistance Among Children And Adults. This Study Examined Institutional Factors Affecting Retention Of HIV Patients On Treatment, Care, And Support Services At Wuse General Hospital, Abuja. A Retrospective Cohort Study Was Used To Access Institutional Factors That Influence HIV Patient Retention On Treatment. About 4,564 HIV Patients Were Ever Enrolled On A Treatment Programme, And 2,791 Patients Are Currently Accessing Treatment. A Total Of 240 Clients Were Recruited For The Study, And A Pre-Tested Interviewer-Administered Semi-Structured Questionnaire Was Used For Data Collection. Data Were Entered Into Stata/MP 15.0 And Then Exported Into SPSS Version 23.0 For Statistical Analysis Of The 240 Respondents Interviewed, The Main Institutional Factor Affecting Retentions Were Long Waiting Time (61.7%), High Patient Load (46.9%), Inadequate Space For Clinics (48.3%), Poor Quality Of Services (40.8%), Difficulty In Accessing Health Facility (32.9%) And Inadequate Health Workers/Staff (31.3%). A Review Of Socio-Demographic Characteristics Of Respondents And Institutional Related Factors Affecting Retention In Treatment Showed An Association Between Marital Status (P=0.000), Religion (P=0.006), Employment Status (P=0.009), And Institutional Related Factors Affecting Retention In Care. Retention Of HIV Patients In Treatment And Care Support Services Is A Major Determinant In Achieving Sustained Viral Suppression And Reduced Community HIV Transmission. Therefore, Strategies To Mitigate Institutional Barriers To Treatment Retention Should Be Promoted To Optimize Retention Of HIV Patients In Care.
Effect of Reminder Tools on Drug Adherence among Patients on Anti-retroviral Drug in Specialist Hospital Yola, Adamawa State: A Randomized Field Trial
Authors: Jenewari Joseph Atiye
Published: July 2021

A Minimum Of 95% Drug Adherence Is Necessary To Achieve Immunological And Virological Success In Antiretroviral Therapy, And To Attain This Level; Patients Need To Be Assisted. The Study Therefore Aimed At Comparing The Effect Of Reminder Tools On Antiretroviral Drug Adherence Among People Living With Human Immunodeficiency Virus. The Study Was A Randomised Field Trial. Questionnaire And Adherence Assessment Forms Were Administered To Two Hundred, And Twenty-Five Patients, And Information Was Elicited On Socio-Demographic History, Antiretroviral Drug Usage, And Adherence Behaviour. Alarm Clocks And Counselling Were Given To One Group, Stickers, Reminder Cards, And Counselling To The Second Group, While Counselling Alone Was Given To The Third Group As Interventions. Three Months Later, Data Were Collected From The Same Patients In Order To Compare The Effect Reminder Tools Had On Antiretroviral Drug Adherence Among The Patients. Data Were Entered Into Epi Info Version 3.5.1 2008 Statistical Software And Analyzed. The Optimum Adherence Levels Were 78.7%, 80.0%, And 84.0% At Pre-Intervention Among Groups That Had Alarm Clock With Counselling, Sticker, Reminder Card With Counselling, And Those That Had Counselling Alone Respectively. The Drug Side Effect Was Negatively Associated With Adherence Level (P< 0.05), While Pill Count Was Not Associated With Adherence Level (P>0.05). At Post-Intervention, The Adherence Levels Increased By 18.5%, 6.8%, And 1.9%, Respectively, Among Groups That Had Alarm Clock With Counselling (P<0.05), Sticker, Reminder Card With Counselling (P>0.05), And Those That Had Counselling Alone (P>0.05). The Alarm Clock Was More Effective Than Stickers And Hand-Held Cards In Improving Adherence.
Economic Factors Affecting Retention of HIV Patient on Treatment at Wuse General Hospital, Abuja, Nigeria
Authors: Ado Uba Sabo
Published: July 2021

The Economic Barriers To The Retention Of HIV Patient On Treatment Is A Challenge To Optimal Viral Suppression. This Study Examined Economic Factors Related To Retention Such As Employment Status, Food Insecurity And Cost Of Transportation To Health Facility That May Influence Retention At Wuse General Hospital, Abuja. A Retrospective Cohort Study Design Was Used To Access Economic Factors That Influence The Retention Of HIV Patients On Treatment. A Total Of 240 Clients Were Recruited, And A Pre-Tested Interviewer-Administered Semi-Structured Questionnaire Was Used For Data Collection. Data Were Entered Into Stata/MP 15.0 And Then Exported Into SPSS Version 23.0 For Statistical Analysis. Of The 240 Respondents Interviewed. The Findings Revealed That There Is An Association Between Socio-Demographic And Employment Status And Retention In Care. The Results Show That Younger Ages (20-49), Being Males (64.1%) And Unemployed (72.3%), Are More Likely To Be Associated With Retention (P<0.047). The Association Between Socio-Economic Characteristics Of Respondents And Cost Of Travelling To Facility (P=0.016) And Rural Of Place Residence (P=0.000) Was Statistically Significant, Respectively. This Study Also Reveals That The Cost Of Transportation Less Than N200 Has Significant Relationships With Retention In At The Study Site (P=0.016). To Address The Challenges Related To Travel Distance To Health Facility And High Transport Cost, Patients Should Be Continually Encouraged To Access Treatment At Their Nearest Clinic Of Their Choice. Linking Unemployed HIV Patients To Economic Empowerment Programmes Will Help Improve Their Economic Status.
Knowledge, Attitude and Practice among the Moi University College of Health Sciences Finalists Undergraduate Students at Moi Teaching and Referral Hospital on Environmental Carcinogens in Eldoret, Uasin Gishu County, Kenya
Authors: Ayumba Zainabu Kadesa
Published: July 2021

This Study Aimed To Bridge The Gap Between Cancer And Environmental Causes, Push For Improved Prevention, Early Screening, And Better Surveillance On Indicators Of Poor Health Linked To Cancer. The Objective Assessed Knowledge, Attitude, And Practice Among Moi University College Of Health Sciences Finalist Undergraduate Students On Environmental Carcinogens In Eldoret, Kenya. The Study Site Was MTRH, With A Cross-Sectional Study Design. The Study Population Was The Adult Finalist Undergraduate Students In The College Of Health Sciences At MTRH. Inclusion Criteria: Adult Finalist Undergraduate Students In The College Of Health Sciences Willing To Share Information And Consenting To Participate. Sample Size Was Determined After The Census Of All The Participants And Meeting Inclusion Criteria. Mixed Sampling Was Used. Data Collection Tools Were A Pre-Validated Structured Questionnaire, Observation Checklist, And Secondary Data. Data Collection Was Done Using Google Forms. Data Were Cleaned And Checked For Completeness. Statistical Analysis And Cross-Tabulation For Variables Were Done Using SPSS Version 26. Data Presentation Was Through Tables, Graphs, And Prose Formats. The Results Of The Study Were As Follows: There Were 40 Males And 22 Females, Ratio-1.82:1. Modal Age Was 22years (19.67%). Prior To Joining The University, 61.29% Had Encountered Cancer Cases. 36% Agreed That They Were Not Aware Of Predisposing Factors, While 32% And 12% Agreed That Tobacco Users And Factory Workers Were Predisposed, Respectively. 28 Respondents Used Plastic Containers, 1.61% Used Tobacco, And 21 Took Alcohol. 92% Were Never Screened For Cancer, Though 17 Females And 26 Males Did Self-Examination At Least Once A Month.
Determinants of HIV Treatment Adherence in Ethnically Diverse and Economically Disadvantaged Patients in a Tertiary Hospital, Nigeria
Authors: Olugbenga Ijaodola Aremu
Published: July 2021

Antiretroviral Therapy (ART) Has Decreased The Mortality And Morbidity Of HIV/AIDS, And High Adherence To ART (>95%) Is Necessary For A Good Therapeutic Outcome. Non-Adherence Can Lead To Drug-Resistant HIV Caused By Failure To Achieve Maximal Viral Suppression. Little Is Known About Adherence To ART And Its Determinants Among Ethnically Diverse And Economically Disadvantaged Patients. The Purpose Of The Study Was To Identify The Level Of Adherence And Describe Factors That Influence ART Adherence Among Ethnically Diverse And Economically Disadvantaged Patients. This Is With A View To Providing Information That Could Help Health Care Providers Understand Patient Motivations For Discontinuing Their Antiretroviral Treatment And Helping Patients Collaboratively Develop Treatment Regimens That Facilitate Adherence And Optimize The Outcomes Of HIV/AIDS Therapy. A Cross-Sectional Descriptive Survey Was Used. Data Were Collected Among 400 HIV-Infected Patients On ARV Who Received Pretreatment And Ongoing Adherence Counseling And Education Since 2010 Using A Self-Administered Questionnaire. The Data Were Analyzed Using Statistical Package For Social Sciences (SPSS). Findings Showed That The Self-Reported Adherence To The Specific Timing For Taking The Medications (Medication Schedule) Was Significantly Low (8.3%). The Major Factors For Non-Adherence To Medication Reported In This Study Were Being Busy At Work Or School, Forgetfulness, Fasting And Travelling Away From Home. Also, Employment Status Was Associated With Poor Adherence, Which May Be Corroborated By The Major Reason For Non-Adherence (Busy At Work Or School). This Study Is One Of The First Steps In The Exploration Of The Relationship Of Factors Responsible And Medication Adherence Among HIV Patients. This Study Used Three Different Measures Of Medication Adherence. These Are Patients’ Knowledge Of The Benefits Of Taking The Drugs, Adherence To A Medication Schedule, And The Number Of Prescribed Doses Of Medications Missed. Health Care Providers Must Identify Possible Barriers To Adherence At The Earliest And Provide Appropriate Solutions. These Factors Should Be Considered When Designing And Implementing Adherence Interventions.
Direct, Indirect and Conditional Indirect Effects of Communication and Career Anxiety on Perceived Stress during Interviews in University Students – A PLS SEM Model
Authors:   Rajasthan Technical University, Kota, Rajasthan., Alvi Irum
Published: July 2021

By exploring the connections between communication and career anxiety and perceived stress, the current study contributes to a more nuanced appreciation of the university students’ emotional and psychological frame of mind during interviews. The study evaluates the direct, indirect and conditional indirect effect of CA on perceived stress PS during interviews. The study also presents a complex research model, based on Preacher, Rucker, and Hayes (2007) model where the independent variable CA has a moderating effect on FCA, which is the mediator. The model is validated using empirical data, sample size 177 with 124 males (70.1%), and 53 (29.9%) females, with PLS-SEM using Smart PLS 3 (3.2.9). To test the hypotheses formulated, two tests were conducted using the same sample; the first one verified the direct and mediating hypotheses, the next verified the moderated mediation hypothesis. The results indicate CA affects PS. Secondly, FCA mediates the effect of CA on PS. Moreover, the study confirms the effect of moderation as CA moderates the effect of FCA on PS, such that the relationship between FCA and PS is weaker when CA is small compared to when it’s high, however at very higher level the effect is seen to dampen and weaker. The implications are discussed.
Water balance computation and water quality improvement evaluation for Yanghe Basin in a semiarid area of North China using coupled MIKE SHE/MIKE 11 modeling
Authors: Liu Ruifen , Li Zeshi , Xin Xiaokang , Liu Defu , Zhang Jialei , Yang Zhengjian
Published: July 2021

Water shortage and water pollution are two prominent issues in North China. Understanding hydrological cycle and water quality changes in response to pollution control measures is fundamental for a better water management there. Using coupled MIKE SHE/MIKE 11 modeling, various hydrological components in Yanghe Basin in a semiarid area of North China were quantified for three typical hydrological years and concentrations of COD and TP in a national monitoring section of Yanghe were evaluated with/without pollution control measures. The modeling results show that the underground water storage of Yanghe Basin becomes depleted due to evapotranspiration compensation and groundwater utilization regardless of hydrological condition, indicating an unsustainable in-situ water resource utilization. Water quality goals set for Yanghe (COD ≤ 20 mg/L and TP ≤ 0.2 mg/L) can hardly be achieved if pollution control measures are not taken, especially for a dry hydrological year. Depending on hydrological conditions, non-point source control technology-related projects in a 109-km2 village and a 7-km river-channel wetland in mainstream of Yanghe will have a positive effect or negligible effect on water quality improvement. To meet water quality goals, implementation of three wetlands is an effective and economic way.
Methylated mud snail protein as a bio-flocculant for high turbidity wastewater treatment
Authors: Mao Shaohui , Xu Xiaohui , Zhang Linjiang , Bai Bo , Hu Na , Wang Honglun
Published: July 2021

The authors reported a potential candidate methylated mud snail protein (MeMsp) as an effective and eco-friendly flocculant to treat the high turbidity wastewater. MeMsp was obtained by extraction of mud snail protein (Msp) through isoelectric precipitation (PSC-IP) and then methylated via the esterification with side-chain carboxyl. Structural characterization of FT-IR, zeta potential and elemental analysis were carried out and further confirmed the successful of the methylation. Flocculation experiments with kaolin suspension simulated wastewater indicated that MeMsp-24 displayed more excellent flocculation efficiency at a low dosage. At the optimum dosage 27 mg/L, the maximum clarification efficiency of MeMsp-24 was 97.46% under pH 7.0. Furthermore, MeMsp-24 exhibited a wide flocculation window in the pH range 1.0–9.0, and faster sedimentation velocity and larger flocs size. In addition, MeMsp-24 exhibited 92.12% clarification efficiency in treating railway tunnel construction effluent. The flocculation kinetic and mechanism analysis revealed that the most effective particle collision occurred at the optimal dosage, with charge neutralization and adhesion playing irreplaceable roles in different environments, respectively. Therefore, through extraction and methylation modification, MeMsp could be a promising eco-friendly flocculant for high turbidity wastewater treatment.
Chidamide Inhibits Cell Proliferation via the PI3K/AKT Pathway in K562 Cells Based on Network Pharmacology and Experimental Validation
Authors: Liang Simin , Zhou Xiaojia , Cai Duo , Rodrigues-Lima Fernando , Wang Li
Published: July 2021

Background:

Chidamide, a novel benzamide-type histone deacetylase (HDAC) inhibitor, exerts antitumor
effects on several types of cancer. However, the role of Chidamide in chronic myeloid leukemia (CML)
remains elusive. Therefore, the present study aimed to investigate the effects of Chidamide on CML cell proliferation
and explore its underlying mechanism.

Methods:

Cell proliferation was assessed by CCK-8 assay, cell cycle distribution and apoptosis were detected
by flow cytometry and the expression of related proteins was evaluated by western blot analysis. The potential
mechanisms were systematically explored by the network-based pharmacological methods, including Gene Ontology
and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses.

Results:

The results revealed that Chidamide inhibited the proliferation of K562 cells in a dose- and time-dependent
manner. In addition, Chidamide blocked cells in the G0/G1 phase via downregulating cyclin-dependent kinase
4, and induced apoptosis via upregulating Bax and downregulating of Bcl-2. Additionally, using network-
based pharmacological methods, we found that PI3K/AKT signaling pathway is involved and significantly
related to cell proliferation in CML. Intriguingly, cell treatment with Chidamide suppressed the activation of
the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway via decreasing the levels of
phosphorylated (p)-PI3K and p-AKT. Moreover, insulin-like growth factor 1 (IGF-1), a PI3K/AKT activator, reversed
the inhibitory effects of Chidamide on K562 cell proliferation.

Conclusion:

The study demonstrated that Chidamide may inhibit the proliferation of K562 cells by promoting
cell cycle arrest and apoptosis via suppressing the PI3K/AKT pathway, suggesting that Chidamide could be a
promising approach to the treatment of CML.
Bruton's Tyrosine Kinase Inhibition in the Treatment of Preclinical Models and Multiple Sclerosis
Authors: Steinmaurer Anja , Wimmer Isabella , Berger Thomas , Rommer Paulus S , Sellner Johann
Published: July 2021

:

Significant progress has been made to understand the immunopathogenesis of multiple sclerosis (MS) over recent years. Successful clinical trials with CD20-depleting monoclonal antibodies have corroborated the fundamental role of B cells in the pathogenesis of MS and reinforced the notion that cells of the B cell lineage are an attractive treatment target. Therapeutic inhibition of Bruton's tyrosine kinase (BTK), an enzyme involved in B cell and myeloid cell activation and function, is regarded as a next-generation approach that aims to attenuate both errant innate and adaptive immune functions. Moreover, brain-penetrant BTK inhibitors may impact compartmentalized inflammation and neurodegeneration within the central nervous system by targeting brain-resident B cells and microglia, respectively. Preclinical studies in animal models of MS corroborated an impact of BTK inhibition on meningeal inflammation and cortical demyelination. Notably, BTK inhibition attenuated the antigen-presenting capacity of B cells and the generation of encephalitogenic T cells. Evobrutinib, a selective oral BTK inhibitor, has been tested recently in a phase 2 study of patients with relapsing-remitting MS. The study met the primary endpoint of a significantly reduced cumulative number of Gadolinium-enhancing lesions under treatment with evobrutinib compared to placebo treatment. Thus, the results of ongoing phase 2 and 3 studies with evobrutinib, fenobrutinib, and tolebrutinib in relapsing-remitting and progressive MS are eagerly awaited. This review article introduces the physiological role of BTK, summarizes the pre-clinical and trial evidence, and addresses the potential beneficial effects of BTK inhibition in MS.
Oxidative Stress in the Early Stage of Psychosis
Authors: Ventriglio Antonio , Bellomo Antonello , Donato Favale , Iris Bonfitto , Giovanna Vitrani , Dario Di Sabatino , Edwige Cuozzo , Di Gioia Ilaria  , Pettorruso Mauro , Perna Giampaolo , Valchera Alessandro , De Berardis Domenico
Published: July 2021

Background:

In the past few decades, increasing evidence in the literature has appeared describing the role of the antioxidant defense system and redox signaling in the multifactorial pathophysiology of psychosis. It is of interest to clinicians and researchers alike that abnormalities of the antioxidant defense system are associated with alterations of cellular membranes, immune functions and neurotransmission, all of which have some clinical implications.

Methods:

This narrative review summarizes the evidence regarding oxidative stress in the early stages of psychosis. We included 136 peer-reviewed articles published from 2007 to 2020 on PubMed EMBASE, The Cochrane Library and Google Scholar.

Results:

Patients affected by psychotic disorders show a decreased level of non-enzymatic antioxidants, an increased level of lipid peroxides, nitric oxides, and a homeostatic imbalance of purine catabolism. In particular, a significantly reduced antioxidant defense has been described in the early onset first episode of psychosis, including reduced levels of glutathione. Also, it has been shown that a decreased basal low-antioxidant capacity correlates with cognitive deficits and negative symptoms, mostly related to glutamate-receptor hypofunction. In addition, atypical antipsychotic drugs seem to show significant antioxidant activity. These factors are critical in order to treat cases of first-onset psychosis effectively.

Conclusion:

This systematic review indicates the importance that must be given to anti-oxidant defense systems.
2',6'-dihydroxy-4'-methoxy Dihydrochalcone Improves the Cognitive Impairment of Alzheimer's Disease: A Structure-activity Relationship Study
Authors: Gonçalves Ana E. , Malheiros Ângela , Casarin Camila A. , de França Lara , Palomino-Salcedo David L. , Ferreira Leonardo L. G. , Andricopulo Adriano D. , Dávila-Rodríguez María J. , Lacava Leticia C. , de Oliveira Aldo S. , de Souza Marcia M.
Published: July 2021

Background:

Chalcones and dihydrochalcones present potent inhibition of acetylcholinesterase,
currently considered the most efficient approach for symptomatic treatment of
Alzheimer’s disease.

Objective:

The present study aimed to explore the potential benefits of 2',6'-dihydroxy-4'-methoxy
dihydrochalcone on the cognitive deficits of animals submitted to the streptozotocin-induced
Alzheimer's model, as well as evaluating the possible mechanisms of action.

Methods:

Learning and memory functions of different groups of animals were submitted to the
streptozotocin-induced Alzheimer's model (STZ 2.5 mg/mL, i.c.v.) and subsequently treated with
2',6'-dihydroxy-4'-methoxy dihydrochalcone (DHMDC) administered at doses of 5, 15, and 30
mg/kg (p.o.), respectively. Rivastigmine (0,6 mg/kg, i.p.) and vehicle were evaluated in aversive
memory test (inhibitory avoidance test) and spatial memory test (object recognition test). Molecular
docking simulations were performed to predict the binding mode of DHMDC at the peripheral
site of AChE, to analyze noncovalent enzyme-ligand interactions. DFT calculations were carried
out to study well-known acetylcholinesterase inhibitors and DHMDC.

Results:

DHMDC markedly increased the learning and memory of mice. STZ caused a significant
decline of spatial and aversive memories in mice, attenuated by DHMDC (15 and 30 mg/kg). Furthermore,
STZ conspicuously increased lipid peroxidation and compromised the antioxidant levels
in mice brains. DHMDC pretreatment significantly increased GSH activity and other oxidative
stress markers and decreased TBARS level in the brain of STZ administered mice. AChE activity
was significantly decreased by DHMDC in the brain of mice.

Conclusion:

The results together point out that DHMDC may be a useful drug in the management
of dementia.
A Comprehensive Review on the Medicinal Importance; Biological and Therapeutic Efficacy of Lagenaria siceraria (Mol.) (Bottle Gourd) Standley Fruit
Authors: Zahoor Muhammad , Ikram Muhammad , Nazir Nausheen , Naz Sumaira , Batiha Gaber El-Saber , Kamran Abdul Waheed , Tomczyk Michał , Kabrah Ahmed
Published: July 2021

Herbal remedies have been employed for the treatment and management of different diseases
for ages. Herbal medicines are a promising choice over modern synthetic drugs because of
their low side effects and are thus considered to be safe and effective in treating human diseases.
Lagenaria siceraria (Mol.) Standley fruit (Bottle gourd) belongs to the Cucurbitaceae family that
has been used in a different system of traditional medication to treat various diseases. This is a domestic
plant that provides food as well as medication. This vegetable have low caloric values and
high water contents. The edible portion of it contains phytochemicals like vitamins, proteins, choline,
minerals, terpenoids, flavonoids, etc. Several bioactive compounds have been isolated from L.
siceraria, including triterpenoids, sterols, cucurbitacins, flavones, C-glycosides and β-glycosides.
Researchers have evaluated various parts of this plant viz. fruit, root, flowers, and leaves for pharmacological
activities like antianxiety, antidepressant, diuretic, antimicrobial, cytotoxic, antihyperlipidemic,
cardio protective, analgesic, anti-inflammatory, anthelmintic, anti-hyperglycemic, antihepatotoxic,
anti-urolithiatic, antistress, antiulcer, anticancer, hepatoprotective, anthelmintic, immunomodulatory,
and antioxidant. In this review, an attempt has been made to explore its phytochemical
constituents, traditional, medicinal, and pharmacological uses to highlight the therapeutic importance
of this well-known plant. This would be helpful in reviving its importance and will highlight
its several promising aspects to encourage researchers for further research on L. siceraria.
Digital Methods in Developing Textile Products for People with Locomotor Disabilities
Authors: Aluculesei Bianca , Krzywinski Sybille , Curteza Antonela , Avadanei Manuela
Published: July 2021

In the United States, there are 3-4 million wheelchair users, with the number steadily increasing. This book focuses upon the design of garments for wheelchair-users by considering the shape of the body while in the sitting position, the needs of the user (functionality, fashionability, ease-of-use, affordability, safety), as well as the characteristics and properties of the materials used. The book references 186 original resources and includes their direct web link for in-depth reading.
Phenomenology Study : Family Experience in Elderly Care In Depok Jawa Barat
Authors: Hayati Yati Sri , Astari Asti Melani
Published: July 2021

The family has an important role in elderly care at home, where the majority of assistance and long-term care for the elderly is provided by the family. The nurse is responsible for assisting the family in caring for the elderly, so that in the end the family is able to provide elderly care independently at home. This study aims to explore family experiences in caring for the elderly at home. Researchers used qualitative research methods with a phenomenological approach. Data obtained through semi-structured interviews with 6 (six) participants. The research produced 5 themes: care for the elderly is a form of devotion to parents, care for the elderly requires physical and mental readiness, care for the elderly requires knowledge related to the elderly and how to care for the elderly, care for the elderly requires support from extended families, and feel the importance of supporting cadres and health workers. For conclusion, elderly families have a responsibility to meet the needs of the elderly, so that efforts are needed to improve the knowledge and skills of the family in order to properly care for and meet the needs of the elderly.
Ontwikkelingen in de mediterrane landschaps-archeologie aan het GIA. Waar komen we vandaan en waar gaan we naartoe?
Authors: Attema Peter
Published: July 2021

Developments in Mediterranean landscape archaeology at the GIA: Where have we come from and where are we heading? In this paper, I discuss in brief the development of Mediterranean landscape archaeology in Italy as this has taken shape at the Groningen Institute of Archaeology (GIA) from the 1980s onwards in the Pontine Region Project, in southern Lazio, in central Italy, and in the Raganello Archaeological Project, in northern Calabria, in southern Italy. I do this against the theoretical and methodological background of the rise of systematic artefact survey and the fruitful discussions that practitioners have about the interpretation of the archaeological surface record, multidisciplinarity in landscape archaeology research, and the application of new methods and techniques. I end with a few words on the importance of data integration, as is now happening within the framework of the Rome Hinterland Project, an undertaking that is being carried out by the universities of Groningen (coordinator), Durham (in cooperation with the British School at Rome), St. Andrews, Rome (La Sapienza), Leiden and Melbourne.
Op de schouders van reuzen. De archeologie van Noordwest-Europa
Authors: Raemaekers Daan , Arnoldussen Stijn , Nicolay Johan , Peeters Hans
Published: July 2021

On the shoulders of giants: the archaeology of northwestern Europe. From its founding in 1918, the Biologisch-Archaeologisch Instituut has carried out research on stone-age hunter-gatherers, the start and the development of prehistoric farming communities, burial mounds and settlements on the sandy soils, and the occupation of the terp-mound district. This article presents the highlights of a century-long research history and identifies current developments.
Pathomorphological changes in pulmonary vessels at different terms of lethal outcomes of patients with COVID-19
Authors: Todorov S. S. , Deribas V. Yu. , Kazmin A. S. , Reznikova G. L. , Makarenko Yu. M. , Polesovoy F. V. , Todorov (jr) S. S.
Published: July 2021

Objective: to study the pathomorphological changes in the vessels of the lungs at diﬀerent times of death in patients with COVID-19. Material and methods: autopsy protocols of 40 deaths from COVID-19 with histological, histochemical examination, and photoregistration. To determine the degree of pulmonary vascular lesions, the authors developed and applied a semi-quantitative assessment scale for the sign based on counting the aﬀected lung vessels in 10 ﬁelds of view, expressed as a percentage: no sign – (0%), weak sign + (1-25%), moderate sign ++ (26-50%), expressed sign +++ (51-75%), highly expressed sign ++++ (76-100%). Results: during the ﬁrst 14 days of the disease, stasis and swelling of individual endotheliocytes were noted in the vessels of the microvasculature. After 15-21 days of the development of COVID-19, signs of alterations in endothelial cells and microthrombosis were observed in microvessels. After 22-28 days of the disease, the phenomena of repair and hyperplasia of endothelial cells were detected. At diﬀerent times of the development of the disease in the lung tissue, the phenomena of acute respiratory distress syndrome, interstitial pneumonia, and focal pneumoﬁbrosis were observed. Conclusions: the authors believe that COVID-19 is associated with a progressive microvascular endotheliopathy in the lungs which is characterized by swelling, alteration, and later, by hyperplasia, and regeneration of endothelial cells in combination with microthrombosis. Destructive changes in the walls of the microvessels of the lungs have superﬁcial character without the destruction of the reticular frame and basal membranes. Endotheliopathy, microthrombus formation of microvessels of the lungs, and interstitial pneumonia create a vicious circle of severe respiratory failure, which must be taken into account in the clinic to correct the treatment of patients with COVID-19.
Prognostic value of secondary hyperaldosteronism in patients with chronic heart failure with preserved ejection fraction
Authors: Shevelok A. N.
Published: July 2021

Purpose: to investigate the prognostic value of secondary hyperaldosteronism patients with heart failure with preserved ejection fraction. Materials and methods: prospective cohort study included 158 patients with hyperaldosteronism and heart failure with preserved ejection fraction. Baseline blood aldosterone levels were determined in all patients. Hyperaldosteronemia was diagnosed when the plasma aldosterone level was > 160 pg/ml. The primary endpoint was all-cause mortality. Results: at baseline, hyperaldosteronemia was detected in 59 of 158 patients (37.3%). Hyperaldosteronemic patients were younger, had higher functional class and NT-proBNP level, and a higher rate of comorbidity (all Ps <0.05). Over a median follow‐up of 32 (28-38) months, a total of 50 (37.6%) patients died. Cardiovascular death occurred in 32 (20.3%) cases, non-cardiovascular – in 18 (11.4%) cases. A total of 65 (41.1%) patients were hospitalized for HF. High aldosterone levels were associated with a significant (p <0.05) increase in the risk of hospitalization for HF (adjusted odds ratio (OR) 2.14, 95% confidence interval (CI) 1.34-9.68), all-cause death (OR 1.64; 95% CI 1.23-7.65, P = 0.033) and HF death (OR 1.56; 95 % CI 1.14-11.3, P = 0.021). Conclusion: Hyperaldosteronism in patients with heart failure with preserved ejection fraction secondary hyperaldosteronism is an independent predictor of hospitalization for heart failure, all-cause, and cardiovascular mortality. The inclusion of plasma aldosterone level in the existing prognosis models of heart failure with preserved ejection fraction will help improve their predictive value and optimize the management of high-risk patients.
Status Quo and Research Trends of Neurosurgical Departments in China: Bibliometric and Scientometric Analyses (Preprint)
Authors: Ni Bowen , He Minyi , Cao Bei , He Jianmin , Liu Yawei , Zhao Zhen
Published: July 2021

BACKGROUND

Modern neurosurgery is a relatively young discipline characterized by finesse and complexity. In recent years, neurosurgery in China has made continuous developments, with long-term progress and outstanding discoveries in many aspects of the field.

OBJECTIVE

This scientometric investigation aimed to comprehensively provide insight into the development trends of neurosurgery in China, to demonstrate how the field has evolved.

METHODS

PubMed database was searched to retrieve relevant papers published between 1988 and 2018 from neurosurgery institutions in China. The database of the National Natural Science Foundation of China was also retrieved for funding information. Information (eg, year of publication, journal, institute of origin) and keywords were collected from each paper after removing duplicates and filtering unintentional words. Co-word analysis was performed on the papers’ keywords, and a time distribution matrix of coexisting keywords in a given paper (ie, termed co-words) was established. Co-words were clustered according to their growth rate within years and visually presented with a mountain plot and a heatmap. Trends and potential subspecialties were identified, and each topic, represented either by a co-word from publications or funding from the National Natural Science Foundation of China during the period from 2011 to 2018, was collected and analyzed.

RESULTS

Within 15,972 publications on neurosurgery from institutions in China, diagnostic image was found to coexist the most with other keywords. Cluster 0, represented by diagnostic image with retrospective study, contained emerging topics with great developmental potential and demonstrated high growth rates in recent years. This finding suggests that the topics represented in Cluster 0 may represent future areas of important neurosurgical research. We also found that the developmental trend of China’s neurosurgical research is highly correlated with National Natural Science Foundation of China funding acquisition.

CONCLUSIONS

Co-word analysis and visualization results provided insight into the emerging research topics that are of vital importance, which can be used as a reference by neurosurgeons and researchers for future investigations. In this study, our analysis strategy based on co-word biclustering was able to clearly demonstrate current academic subject development; therefore, co-word biclustering is a reliable bibliometric analysis strategy.
Web- and Mindfulness-Based Intervention to Prevent Chronic Pain After Cardiac Surgery: Protocol for a Pilot Randomized Controlled Trial (Preprint)
Authors: Martorella Geraldine , Hanley Adam W , Pickett Scott M , Gelinas Céline
Published: July 2021

BACKGROUND

Cardiac surgery is a frequently performed procedure. However, pain after cardiac surgery may become chronic (lasting >3 months) in adults. Once discharged from the hospital, patients are at greater risk of developing chronic postsurgical pain (CPSP) and of prolonged opioid use, as they need to self-manage their pain. Psychological risk and protective factors such as pain-related catastrophic thoughts and pain acceptance determine their ability to cope and their use of opioids, which is crucial for self-management of pain. Studies on mindfulness-based cognitive therapy (MBCT) have multiplied their potential effects on pain acceptance and catastrophic thoughts. However, web-based MBCT for the prevention of CPSP has not yet been examined.

OBJECTIVE

The aim of this study is to pilot test a 4-week-long web-based MBCT intervention for adults following discharge from the hospital by assessing the acceptability or feasibility of the intervention and examining preliminary effects on pain intensity, pain interference with activities and opioid use, and pain acceptance and catastrophic thoughts in the 6 months following surgery.

METHODS

A double-blinded pilot randomized controlled trial will be used to assess a web-based MBCT intervention. Patients will be selected according to the following criteria: age ≥18 years; first-time elective cardiac surgery via a median sternotomy; worst pain in the past week score ≥4/10; ability to understand and complete questionnaires in English; and ability to use an electronic device such as a smartphone, computer, or tablet. After baseline measures, 32 participants will be randomized into two groups: one receiving both the brief, 4-week-long web-based MBCT intervention and usual care (experimental group) and the other receiving only one standardized, web-based educational session with weekly reminders and usual care (attention control group). Peer-reviewed competitive funding was received from Florida State University’s Council on Research & Creativity in January 2021, as well as research ethics approval from Florida State University's institutional review board.

RESULTS

Recruitment began in June 2021. Unfortunately, because of the current COVID-19 pandemic, recruitment is not progressing as expected. Recruitment strategies are constantly monitored and updated according to latest data and restrictions surrounding the pandemic.

CONCLUSIONS

This research is significant because it targets the trajectory of CPSP, a leading cause of disability and opioid misuse. This is the first study to assess MBCT for the prevention of CPSP after cardiac surgery in the recovery phase. This approach is innovative because it promotes self-management of pain through the modulation of individual factors. If successful, the intervention could be expanded to numerous populations at risk of chronic pain.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/30951
Social Media Platforms Listening Study on Atopic Dermatitis: Quantitative and Qualitative Findings (Preprint)
Authors: Voillot Paméla , Riche Brigitte , Portafax Michel , Foulquié Pierre , Gedik Anaïs , Barbarot Sébastien , Misery Laurent , Héas Stéphane , Mebarki Adel , Texier Nathalie , Schück Stéphane
Published: July 2021

BACKGROUND

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory disease that occurs most frequently in children but also affects many adults. Social media have become key tools for finding and disseminating medical information.

OBJECTIVE

The aims of this study were to identify the main themes of discussion, the difficulties encountered by patients with respect to AD, the impact of the pathology on quality of life (QoL; physical, psychological, social, or financial), and to study the perception of patients regarding their treatment.

METHODS

A retrospective study was carried out by collecting social media posts in French language written by internet users mentioning their experience with AD, their QoL, and their treatments. Messages related to AD discomfort posted between July 1, 2010, and October 23, 2020, were extracted from French-speaking publicly available online forums. Automatic and manual extractions were implemented to create a general corpus and 2 subcorpuses depending on the level of control of the disease.

RESULTS

A total of 33,115 messages associated with AD were included in the analysis corpus after extraction and cleaning. These messages were posted by 15,857 separate web users, most of them being women younger than 40 years. Tips to manage AD and everyday hygiene/treatments were among the most discussed topics for controlled AD subcorpus, while baby-related topics and therapeutic failure were among the most discussed topics for insufficiently controlled AD subcorpus. QoL was discussed in both subcorpuses with a higher proportion in the controlled AD subcorpus. Treatments and their perception were also discussed by web users.

CONCLUSIONS

More than just emotional or peer support, patients with AD turn to online forums to discuss their health. Our findings show the need for an intersection between social media and health care and the importance of developing new approaches such as the Atopic Dermatitis Control Tool, which is a patient-related disease severity assessment tool focused on patients with AD.
Breaking the Data Value-Privacy Paradox in Mobile Mental Health Systems Through User-Centered Privacy Protection: A Web-Based Survey Study (Preprint)
Authors: Zhang Dongsong , Lim Jaewan , Zhou Lina , Dahl Alicia A
Published: July 2021

BACKGROUND

Mobile mental health systems (MMHS) have been increasingly developed and deployed in support of monitoring, management, and intervention with regard to patients with mental disorders. However, many of these systems rely on patient data collected by smartphones or other wearable devices to infer patients’ mental status, which raises privacy concerns. Such a value-privacy paradox poses significant challenges to patients’ adoption and use of MMHS; yet, there has been limited understanding of it.

OBJECTIVE

To address the significant literature gap, this research aims to investigate both the antecedents of patients’ privacy concerns and the effects of privacy concerns on their continuous usage intention with regard to MMHS.

METHODS

Using a web-based survey, this research collected data from 170 participants with MMHS experience recruited from online mental health communities and a university community. The data analyses used both repeated analysis of variance and partial least squares regression.

RESULTS

The results showed that data type (P=.003), data stage (P<.001), privacy victimization experience (P=.01), and privacy awareness (P=.08) have positive effects on privacy concerns. Specifically, users report higher privacy concerns for social interaction data (P=.007) and self-reported data (P=.001) than for biometrics data; privacy concerns are higher for data transmission (P=.01) and data sharing (P<.001) than for data collection. Our results also reveal that privacy concerns have an effect on attitude toward privacy protection (P=.001), which in turn affects continuous usage intention with regard to MMHS.

CONCLUSIONS

This study contributes to the literature by deepening our understanding of the data value-privacy paradox in MMHS research. The findings offer practical guidelines for breaking the paradox through the design of user-centered and privacy-preserving MMHS.
Pengaruh Konsentrasi Ampas Tahu dan Susu Skim terhadap Fisikokimia Yogurt Skim Santan
Authors: Rahmiati Tengku Mia , Muhardina Virna , Sari Putri Meutia
Published: July 2021

Skim coconut milk is a liquid by-product of coconut oil production with limited utilization in food processing. It has nutritional value such as protein, carbohydrate and mineral, so it is possible to be used as raw material for processing food products, such as yogurt. The use of tofu waste flour and skim milk as prebiotic and protein source is intended to improve the physical quality of yogurt skim coconut milk. This study used a completely randomized design (CRD) with 2 factors and 3 levels (1,5%, 3%, and 4,5%), and several skim milk concentrations (10%, 12,5%, and 15%). The results of this study indicated that the addition of tofu waste flour and skim milk have no significant effect on the viscosity of the coconut milk yogurt. In the organoleptic test, the addition of tofu waste flour showed significant effect on panelist perception of flavor, aroma, and color. The higher the percentage of the flour, the lower the panelist preference on flavor, aroma, and color; flavor. High concentration of flour can increase the total of soluble solid content in yogurt. A concentration of 4.5% tofu waste flour and 15% skim milk produced 13,89 oBrix and 15,44 oBrix soluble solids resulting in the highest viscosity value of 609,6 Cp.