bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Penulisan Sejarah untuk Karang Taruna Desa Ngrawan, Kabupaten Semarang
Authors: Sasi Galuh Ambar , Hanandika Vincensius Anggy Setya
Published: August 2023

Sejarah kampung merupakan respon terhadap sejarah nasional Indonesia yang tidak mengakomodasi sejarah lokal apalagi orang-orang biasa di dalam penulisan sejarah. Sekalipun demikian, penyusunannya umumnya ditulis oleh orang dari luar (sejarawan, institusi pemerintah, akademisi, atau atas inisiasi komunitas-komunitas pegiat sejarah, literasi, dan fasilitator penulisan dari luar desa). Realitas ini mendorong sebuah komunitas karang taruna kolaborasi untuk menyusun sejarah kampung mereka sendiri. Akan tetapi, mereka mengalami kesulitan karena terbelenggu oleh inferioritas. Tulisan ini menjelaskan kegiatan pengabdian masyarakat dalam bentuk penulisan sejarah dengan model kolaborasi berbasis aset. Berfokus pada sejarah Rejeban, kegiatan ini tidak hanya menghasilkan luaran dalam bentuk narasi sejarah maupun film dokumenter melainkan perubahan sosial dan transformasi sosial di desa. Terpenting, kegiatan ini mampu menghapus stereotif dan label-label negatif tentang desa dan masyarakatnya serta menempatkan mereka sebagai subjek dalam sejarah, baik sebagai pemilik maupun penulisnya. Dengan demikian, kegiatan ini kiranya menjadi model bagi desa atau komunitas desa lain untuk menuliskan sejarahnya.
Cost-effectiveness of empagliflozin in heart failure patients irrespective of ejection fraction in England
Authors: Kolovos Spyros , Bellanca Leana , Groyer Harinala , Rosano Giuseppe , Gaultney Jennifer , Linden Stephan
Published: August 2023

Aims

Heart failure (HF) is a complex syndrome commonly categorized into two main phenotypes [left ventricular ejection fraction (LVEF) below or above 40%], and although empagliflozin is the first approved medication with proven clinical effectiveness for both phenotypes, its cost-effectiveness of treating the entire HF population remains unknown.

Methods

The analysis was performed utilizing two preexisting, LVEF phenotype-specific cost-effectiveness models to estimate the cost-effectiveness of empagliflozin in adults for the treatment of symptomatic chronic HF, irrespective of ejection fraction (EF). The results of the phenotype-specific models were combined using a population-weighted approach to estimate the deterministic and probabilistic incremental cost-effectiveness ratios (ICERs).

Results

Based on combined results, empagliflozin + standard of care (SoC) is associated with 6.13 life-years (LYs) and 3.92 quality-adjusted life-years (QALYs) compared with 5.98 LYs and 3.76 QALYs for SoC alone over a lifetime, resulting in an incremental difference of 0.15 LYs and 0.16 QALYs, respectively. Total lifetime healthcare costs per patient are £15 246 for empagliflozin + SoC and £13 982 for SoC giving an incremental difference of £1264. The ICER is £7757/QALY, which is substantially lower than the willingness-to-pay (WTP) of £30 000 per QALY used by NICE. The results of the probabilistic sensitivity analyses are in line with the deterministic results.

Conclusion

Empagliflozin is the first efficacious, approved, and cost-effective treatment option for all HF patients, irrespective of EF. The combined ICER was consistently below the WTP threshold. Therefore, empagliflozin offers value for money for the treatment of the full HF population in England.
Trends in occurrence of takotsubo syndrome and association with SARS-CoV-2 infection and COVID-19 vaccination
Authors: Rosh Bar , Naoum Ibrahim , Stein Nili , Jaffe Ronen , Saliba Walid
Published: August 2023

Aims

Takotsubo syndrome (TTS) is a serious heart disease associated with significant morbidity and mortality. TTS has been related to SARS-CoV-2 infection and COVID-19 vaccine; however, the current data are scarce. We aimed to examine the associations between SARS-CoV-2 infection and its vaccine with TTS.

Methods

We conducted a nested case–control study in a cohort of 3 237 909 adults from the largest healthcare provider in Israel. Patients were followed from 1 March 2020 until 31 December 2021 for the occurrence of TTS. Ten randomly selected controls were matched to each case of TTS on age, sex, and duration of follow-up. Exposure to SARS-CoV-2 infection and COVID-19 vaccine in the prior 30 days was assessed in cases and controls.

Results

During the follow-up 144 patients developed TTS and were matched to 1440 controls. The mean age of cases and their matched controls was 71.4 ± 12 years, and 136 (94.4%) of them were women. Conditional logistic regression analysis showed that SARS-CoV-2 infection and COVID-19 vaccine were not associated with an increased risk of TTS; odds ratio (OR) = 2.04 [95% confidence interval (CI), 0.50–8.2] and 0.87 (0.49–1.54), respectively. The absolute number of TTS cases in the prepandemic period (March–December 2018–2019) was 82 in 2018 and 80 in 2019. The number of TTS cases decreased to 56 during the corresponding period of 2020 (first pandemic year) and increased back to 81 in 2022.

Conclusion

No significant association was found between SARS-CoV-2 infection or COVID-19 vaccination and TTS occurrence.
Mitral valve surgery in acute infective endocarditis: long-term outcomes of mitral valve repair versus replacement
Authors: Di Bacco Lorenzo , D’Alonzo Michele , Di Mauro Massimiliano , Petruccelli Rocco Davide , Baudo Massimo , Palacios Camila Mayorga , Benussi Stefano , Muneretto Claudio , Rosati Fabrizio
Published: August 2023

Aims

Timing and surgical strategies in acute infective endocarditis are still questionable. We sought to investigate clinical outcomes of patients undergoing mitral valve repair (MVR) compared with mitral valve replacement [mitral valve prosthesis (MVP)] for acute infective endocarditis.

Methods

From 2004 to 2019, 109 consecutive patients with acute mitral valve infective endocarditis were retrospectively investigated. Patients were divided into two groups according to surgical strategy: MVR 53/109 (48.6%) versus MVP 56/109 (51.4%). Primary end points were in-hospital mortality and overall survival at 10 years. Secondary end point was the freedom from infective endocarditis relapse.

Results

Our institutional surgical approach for infective endocarditis allowed us to achieve MVR in 48.6% of patients. Hospital mortality was comparable between the two groups [MVR: 1/53 (1.9%) versus MVP: 2/56 (3.6%), P = 1.000]. Overall 10-year survival was 80.0 ± 14.1 and 77.2 ± 13.5% for MVR and MVP, respectively (P = 0.648). MVR showed a lower incidence of infective endocarditis relapse compared with MVP (MVR: 93.6 ± 7.1 versus MVP: 80.9 ± 10.8%, P = 0.041). At Cox regression, infective endocarditis relapse was an independent risk factor for death (hazard ratio 4.03; 95% confidence interval 1.41–11.52; P = 0.009).

Conclusion

The tendency to postpone surgery in stable patients with mitral infective endocarditis allowed achievement of MVR in almost 50% of patients. Although repair remains the approach of choice in our institution, no differences between MVR and MVP were reported in terms of early/late survival. However, MVP had a higher incidence of infective endocarditis relapse that represents an independent risk of mortality.
Twenty years of clear aligner therapy: a bibliometric analysis (2002-2022)
Authors: Gong Beiwen , Liu Ziyang , Yang Liya , Sun Xiaomei , Lu Jianjian , Teng Li , Bai Yuxing , Xie Xianju
Published: August 2023

Introduction

Clear aligner (CA) therapy has become popular worldwide but there is little research in the area from the perspective of bibliometrics. The present study aimed to identify the most impactful studies on CA over its 20 years of publishing since 2002.

Methods

The Web of Science database was used to retrieve study records on CA for the period between 2002 and 2022. Two authors manually screened the related studies. CiteSpace was used to analyse the country and institutional co-operation, keywords and citations with the strongest ‘burst’.

Results

The number of CA publications has increased and a total of 613 studies were included in the current analysis. The American Journal of Orthodontics and Dentofacial Orthopedics was the leading publishing journal reporting 79 published CA articles and 1627 total citations. Italy had the most significant productivity in this field (142/613, 23.16%). The United States of America was the leading country with the highest international collaboration. Based on the results of keyword analysis, orthodontic treatment, digital orthodontics, superimposition, and apical root resorption were previous research emphases.

Conclusions

The present analysis indicates that the treatment outcomes of CA therapy is the focus of current studies and provides developments for future research. The results provide an increased and comprehensive understanding of the state of the art of CA treatment.
Comparison of the cytotoxicity of 3D-printed aligners using different post-curing procedures: an in vitro study
Authors: Alessandra Campobasso , Anastasia Ariano , Giovanni Battista , Francesca Posa , Marco Migliorati , Sara Drago , Eleonora Lo Muzio , Giorgio Mori
Published: August 2023

Objective

Three-dimensional (3D) printing technology represents a novel method for manufacturing aligners. The aim of the present study was to assess the in-vitro cytotoxicity of 3D-printed aligners using different post-polymerisation conditions.

Materials

Aligners were printed using the same 3D-print resin (TC-85DAC, Graphy, Seoul, Korea) and printer (AccuFab-L4D, Shining 3D Tech. Co., Hangzhou, China), followed by different post-curing procedures. Six aligners were post-polymerised for 14 min using the Tera Harz Cure and a nitrogen generator curing machine (THC2, Graphy, Seoul, Korea) (P1). A further six aligners were post-cured for 30 min on each side using the Form Cure machine (FormLabs Inc, Somerville, USA) (P2). The aligners were cut into smaller specimens (2 mm×2 mm) and sterilised at 121°C. The specimens were placed in 96-well plates containing Dulbecco’s Modified Eagle’s Medium (DMEM) at 37° for 7 or 14 days. The viability of MC3T3E-1 pre-osteoblasts cultured with DMEM was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The optical density of each cell culture was measured to assess cell viability, following which the data were statistically analysed using two-way and one-way ANOVA (α = 0.05).

Results

The comparison of cytotoxicity revealed statistically significant differences between post-curing procedures and MTT timings (P < 0.001). After 7 and 14 days, the cell viability of P2 was significantly reduced compared to P1 and the control groups (P < 0.001), while P1 showed no significant differences compared to the controls. Overall, P2 post-curing exhibited moderate cytotoxicity, while P1 post-polymerisation was highly biocompatible.

Conclusions

Different post-curing procedures may affect the in-vitro cytotoxicity of 3D-printed aligners. Clinicians should adhere to the manufacturer’s recommendations when using 3D-print resin.
Inflammatory bowel disease in Saudi Arabia: a review article
Authors: Almaghrabi Leena , Almaghrabi Rania
Published: August 2023

Inflammatory Bowel Disease (IBD) encompasses chronic intestinal disorders, like ulcerative colitis (UC) and Crohn's disease, causing gastrointestinal (GI) tract inflammation. Saudi Arabia, particularly among pediatric populations, has seen an increasing prevalence of IBD. Clinical symptoms, including abdominal pain, diarrhea, weight loss, and rectal bleeding, significantly impact patients' lives, requiring lifelong medical care, especially for children. The study highlights the growing burden of IBD in Saudi Arabia due to insufficient epidemiological data and rising disease incidence. Early IBD diagnosis is crucial for successful management and improved outcomes. Effective treatments for mild to moderate UC, such as 5-aminosalicylic acid-based drugs like mesalazine and sulfasalazine, show promising results. However, patients may experience ongoing GI symptoms even after successful treatment, underscoring the need for comprehensive care. Frequent remissions and relapses pose a challenge, necessitating continuous monitoring and appropriate medical intervention. Untreated symptoms can negatively impact patients' well-being and increase healthcare expenditures. Hence, exploring better approaches for long-term symptom control and mucosal repair is essential. In severe cases, surgical interventions like total colectomy become necessary, but the focus should be on optimizing medical therapies to reduce the need for drastic measures. In conclusion, early detection, accurate diagnosis, and proper management of IBD in Saudi Arabia are vital. Collaborative efforts among healthcare professionals, researchers, and policymakers are required to gather comprehensive epidemiological data and develop targeted strategies for improving IBD care. Addressing these challenges and opportunities can enhance the quality of life for IBD patients in Saudi Arabia and potentially alleviate the burden on the healthcare system.
Gestufte, evidenzbasierte, integrierte Versorgung
Authors:   Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE),, Lambert Martin , Karow Anne ,   Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE),, Schulz Holger ,   Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE), Gallinat Jürgen ,   Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
Published: August 2023

Germany, like many other countries, is affected by the high and steadily increasing health and economic burden of mental illness. In 2015, the reference year of the RECOVER study, mental illnesses in Germany caused annual societal costs of 146 billion euros, 4.8% of the gross domestic product, and the trend is rising. (1) Of these, 44.4 billion euros were direct health costs, including 24.9 billion euros in hospital costs. (2) According tothe Organisation for Economic Co-operation and Development (OECD), the insufficient establishment of evidence-based care models in Germany plays a role here, especially for people with severe mental illnesses. (3).
Die Profession war in der Pandemie stumm
Authors:   Universität Bremen, Manow Philip
Published: August 2023

If you are interested in a political portrait of the late Merkel years, you will find it in a somewhat remote and initially inconspicuous place, namely here: https://www.gesis.org/angebot/daten-findenund-abrufen/ausgewaehlte-nationale-daten/ bundespresseamt .
Die neuen „Leitplanken“ im AMNOG-Prozess
Authors:   Verband forschender Arzneimittelhersteller e. V., Rasch Andrej
Published: August 2023

The AMNOG process has been legally adapted several times in recent years. A significant change occurred most recently with the GKV-Financial Stabilisation Act (GKV-FinStG), which was passed at the end of 2022. The legal package of measures includes, among other things, new specifications for the reimbursement amount negotiations, which change the basic principle of the AMNOG. According to these new specifications (so-called ‚guard rails‘), a new medicinal product may not cost more than the comparator therapy in certain cases despite the proven additional benefit. In the case of an unproven additional benefit, the costs must even be lower. The details of these new requirements are subjected to a critical analysis in the following.
Veränderung der Altersstruktur neuerkrankter Krebspatient:innen zwischen 2010 und 2022 in niedergelassenen Praxen
Authors:   IQVIA, Kostev Karel , Klein Isabel , Isselhard Anna ,   IQVIA,   IQVIA
Published: August 2023

Cancer is one of the most common causes of death worldwide and will be responsible for almost 10 million deaths in 2020. In the same year, about 19 million new cases of cancer were diagnosed worldwide [1]. The incidence of all cancers increased between 1998 and 2012 in most countries and in all age groups worldwide [2]. However, at least in Europe, the USA and part of Asia, this trend was in line with demographic changes and population ageing [3,4]. Cancer risk increases with age, and more than 60% of cancers are diagnosed in people aged 65 or older [5]. However, recent studies suggest a sharp increase in the incidence of cancer in adults under 50 years of age [6-15]. In young people diagnosed with cancer, the disease is often more advanced at the time of diagnosis than in older people, partly due to delayed diagnosis [16].
Geschäftsentwicklungsmodell für die Übergangspflege im Schweizer Projekt „Daheim statt Heim“ – Visualisierung und Dimensionen
Authors:   Institut für Angewandte Pflegewissenschaft der OST Ostschweizer Fachhochschule, St. Gallen, Brenner Rouven , Lux Wilfried ,   Institut für Finance & Law der OST Ostschweizer Fachhochschule, St. Gallen, Gattinger Heidrun ,   Institut für Angewandte Pflegewissenschaft der OST Ostschweizer Fachhochschule, St. Gallen, Kohler Myrta ,   Institut für Angewandte Pflegewissenschaft der OST Ostschweizer Fachhochschule, St. Gallen
Published: August 2023

In the course of the introduction of the Swiss flat rate per case system (SwissDRG) on 1 January 2012 to contain costs in the health care system, a paradigm shift was made in the billing of health care services, away from cost recovery to service financing. In order to cushion any negative effects in this regard due to the introduction, various measures were included by the legislator in the Federal Health Insurance Act (KVG) - one of these protective measures was acute and transitional care (Padrutt, 2019). Acute and transitional care (AÜP) was anchored in Art. 25a para. 2 KVG as part of the reorganisation of care financing. This 14-day prescription by a hospital doctor for a follow-up solution after a hospital stay was intended to prevent so-called ‚bloody discharges‘ - i.e. people should not be discharged home in need of treatment and care due to the shortened duration of treatment and stay (Padrutt, 2019; Zou et al., 2020). Nevertheless, EAP is very rarely prescribed in the inpatient setting in Switzerland or used by those affected.
Redes sociais e a COVID-19
Authors: Oliveira Cristiane Helena Tomaz de , Bueno Géssica Ribeiro , Andrade Kênia Rodrigues , Calarge Tânia Cristina Costa , Petean Gustavo Henrique
Published: August 2023

Este trabalho tem como objetivo analisar o uso das redes sociais por museus universitários, como ferramentas de comunicação externa, durante o período de agosto de 2019 a julho de 2022. A pesquisa emprega técnicas de etnografia para a coleta e análise de dados. Analisando as redes sociais dos museus selecionados, percebeu-se que foram desenvolvidas variadas estratégias para cumprir com o papel social nesse período, e intensificando as ações no período que estiveram temporariamente fechados. O estudo realizado mostrou que a pandemia aproximou os Museus Universitários ao ambiente virtual através do uso das redes sociais, Facebook, Instagram e Youtube, apresentando ao público um novo viés das instituições, além de preservar, salvaguardar, eles podem se adaptar no processo de diálogo com a comunidade. Tal adaptação trouxe aos museus uma nova forma de relacionar-se com seu público, e, que se sugere, permanecer mesmo após a reabertura.
LIÇÕES APRENDIDAS EM TEMPOS PANDÊMICOS: REVISÃO DE ESCOPO SOBRE A ATUAÇÃO DOCENTE E OS IMPACTOS NA SAÚDE
Authors: Caetano Ana Paula Lucas , De Souza Flávia Faissal , Brandão Ana Carolina Barboza , Avanci Joviana Quintes
Published: August 2023

A pandemia de Covid-19 alterou a atuação dos profissionais da educação para o ensino remoto devido à emergência sanitária de saúde pública global. Esse novo formato de trabalho trouxe consequências e desafios para a educação mundial, e deixou legado a ser incorporado na prática educacional. Este estudo teve como objetivo analisar como a literatura científica nacional e internacional abordou o trabalho docente no período da pandemia de COVID-19, bem como a saúde desses profissionais e as lições aprendidas a partir desse contexto. Realizou-se uma revisão de escopo com abrangência nacional e internacional, no período que compreende os anos de 2020 a 2021. Foram analisados 36 estudos e identificados três temáticas principais: (1) atuação docente e estratégias pedagógicas, (2) impactos na saúde física e mental de docentes e (3) lições educacionais aprendidas. Constatou-se que a experiência do trabalho remoto emergencial, sem diretriz política específica e planejamento para desenvolvimento desta nova forma de desenvolvimento do trabalho docente foi complexa e imprevisível em todos os países componentes do estudo. Nos demais países pesquisados, os dados expressam um resultado semelhante ao brasileiro, com dificuldades no acesso e permanência à internet pelos estudantes e professores, além da ausência de equipamentos apropriados para ministrar/assistir as aulas remotas.
INTERVENÇÃO DE ENFERMAGEM PARA PREVENÇÃO DE QUEDA DA PESSOA IDOSA COM TRANSTORNO MENTAL
Authors: De Oliveira Francisco Eduardo Silva , Moreira Andréa Carvalho Araújo , Azevedo Samir Gabriel Vasconcelos , Rocha Sibele Pontes , Diniz Jamylle Lucas , Santos Júlio César de Oliveira
Published: August 2023

Objetivo: aplicar intervenções de enfermagem sobre prevenção de quedas a pessoas idosas com transtornos mentais. Material e Método: Trata-se de uma pesquisa-cuidado, para subsidiar a aplicação das intervenções de enfermagem foi utilizado componentes do Modelo Teórico de Promoção da Saúde, desenvolvido por Nola J. Pender.  A primeira etapa do estudo foi desenvolvida em um Centro de Atenção Psicossocial e a segunda etapa no domicilio dos idosos. A coleta de dados foi   realizada entre os meses de agosto a novembro de 2022, com idosos de idade igual ou superior a 60 anos, que estivessem sendo acompanhados no serviço. A amostra foi composta por 15 idosos. Para a coleta de dados, foi utilizado um formulário estruturado com variáveis sociodemográficas, investigação de saúde e doença e características do domicílio e um instrumento utilizado para avaliar o risco de quedas em idosos. A análise descritiva dos dados, ocorreu por meio do cálculo de frequências absolutas e relativas. Os aspectos éticos da resolução 466/12 foram respeitados em todas as fases do estudo. Resultados: Predominaram mulheres (80,00%), casadas (53,33%), com uma média de idade de 70,52 anos, de cor branca (53,33%) e analfabetos (55,33%). No que se refere às condições de saúde e doença, foi possível observar que o tipo de transtorno mental que mais predominou foi a depressão (60,00%) e a ansiedade (33,33%). Grande parte dos participantes do estudo (73,33%) relataram que já caíram ao menos 6 vezes, em um tempo médio de 1 ano. Ressalta-se que (93,33%) dos idosos não receberam orientações sobre prevenção de quedas no domicilio. Todos os idosos apresentaram alto risco de quedas. As intervenções de enfermagem foram realizadas aos idosos com transtornos mentais com alto risco para quedas. Considerações Finais: A maioria dos idosos tiveram quedas dentro do domicilio, a ocorrência de quedas nesse espaço está relacionada a insegurança do ambiente. Diante disso, a realização da intervenção foi de grande importância para a prevenção a quedas com enfoque na saúde do idoso direcionados aos gestores, profissionais e comunidade.
ATENDIMENTO A PESSOAS IDOSAS EM UM SERVIÇO MÓVEL DE URGÊNCIA: ESTUDO COMPARATIVO ENTRE AS FAIXAS ETÁRIAS
Authors: Leite Marinês Tambara , Thiel Lucia Oliveira , Hildebrandt Leila Mariza , Kinalski Sandra da Silva , Biasuz Sandra , Both Caroline Thais , De Moura Leticia
Published: August 2023

Este estudo teve por objetivo comparar o perfil dos atendimentos realizados por um Serviço de Atendimento Móvel de Urgência (SAMU) a pessoas idosas e de pessoas idosas mais idosas. Trata-se de um estudo analítico, transversal, realizado com dados registrados nos Boletins de Atendimento Pré-hospitalar do SAMU. Os dados foram analisados por meio de frequências absolutas e relativas e a comparação de frequência, entre os grupos, pelo teste qui-quadrado. Dos 487 atendimentos realizados, 46,1% foram a pessoas idosas do sexo masculino e 53,7% do sexo feminino, 56,47% estavam na faixa etária de 60 a 79 anos e 43,33% tinham 80 anos ou mais de idade. Independentemente da idade a maioria dos chamados teve origem nos domicílios dos usuários. Destacaram-se as complicações cardiorrespiratórias e neurológicas, em ambos os grupos, como causas dos atendimentos, responsáveis pelos chamados de 39,7% dos idosos de 60 a 79 anos, e para 41,5% dos idosos que possuíam 80 anos ou mais. Conhecer o perfil epidemiológico proporciona, além de subsídios para formulação de políticas públicas, o conhecimento das demandas emergentes nos serviços de saúde.
AVALIAÇÃO DO RISCO DE LESÃO POR PRESSÃO EM PACIENTES EM TRATAMENTO ONCOLÓGICO
Authors: Da Silva Taline Gonçalves , Mendes Rafaella Vilaça de Lima , Cesario Danilo dos Santos , Dázio Eliza Maria Rezende , De Araújo José César , Chini Lucélia Terra , Do Nascimento Murilo César , Costa Andreia Cristina Barbosa
Published: August 2023

Este estudo teve por objetivo avaliar o risco de desenvolvimento de lesão por pressão em pacientes internados na unidade de oncologia. Trata-se de estudo descritivo, analítico, transversal e de natureza quantitativa aprovado pelo Comitê de Ética da Universidade Federal de Alfenas sob  parecer nº 5.916.419. A população de interesse foi composta por pacientes em tratamento oncológico de ambos os sexos, com idade acima de 18 anos e com tempo de internação superior a 24 horas.  A coleta de dados ocorreu no período de março a maio de 2023, em uma unidade de internação oncológica. Foram utilizados o instrumento de caracterização sociodemográfica e clínica e a escala de Braden. Para análise estatística descritiva e inferencial foi utilizado o software Statistical Package for the Social Science (SPSS). Participaram 100 pacientes. A média da pontuação da Escala de Braden foi de 17,71 pontos, o que representa baixo risco de desenvolvimento de lesão por pressão. O presente estudo permitiu avaliar o risco de desenvolvimento de lesão por pressão em pacientes internados na unidade de oncologia por meio da Escala de Braden, sendo que, para esta amostra, o risco foi classificado como baixo.
ANÁLISE DOS INDICADORES DE BOAS PRÁTICAS DURANTE A ASSISTÊNCIA NO TRABALHO DE PARTO E NASCIMENTO EM UM HOSPITAL TERCIÁRIO DE SANTA CATARINA
Authors: Zibell Elisa Bompani , Knaul Luis Henrique , Tomaz Raquel Ronconi , De Lima Paola
Published: August 2023

Objetivos: Analisar os indicadores de boas práticas de assistência à mulher no trabalho de parto e pós-parto imediato em um hospital terciário de Santa Catarina.  Métodos: Estudo observacional, analítico, transversal e retrospectivo, com abordagem quantitativa, onde foi realizada análise de prontuários das pacientes admitidas, entre dezembro de 2021 a julho de 2022. Sendo uma pesquisa censitária, na qual todas as pacientes que preencheram os critérios de elegibilidade integraram o estudo.  Resultados: Foram analisados 1328 prontuários, destes, 549 atenderam os critérios de inclusão. Observamos bons índices de partos normais (58,57%) quando comparados a média nacional, referente aos indicadores de boas práticas, o contato pele a pele ao nascer, amamentação na primeira hora de vida e clampeamento tardio são executados de maneira satisfatória, assim como, os baixos índices de episiotomia e parto instrumental. Contudo, a alimentação no trabalho de parto e utilização de métodos não farmacológicos possuem baixa adesão. Conclusão: Pode-se concluir que o hospital estudado realiza, de forma global, boas práticas conforme o preconizado pelo Ministério da Saúde e OMS.
Authors: Wiyadhi Muhammad Danung Putra , Siregar Christian Halomoan , Sindiarti Ardila , Cahyadi Willy Anugrah , Mukhar Husneni
Published: August 2023

Bedrest is an enforced condition for the patient to lie in bed. The patient is restricted to limited activities due to disease or disorders of the body's organs that are either physical or mental needing long term recovery. This situation has a negative impact such as an increase in temperature in the back area of the body that is in direct contact with the bedding. An increase in body temperature between the patient's body and the bedding can cause the patient's skin to become redder, to swell, prone to skin peeling, and thus making it more susceptible to infection. The use of common mattress in bed rest patients can potentially have a worse impact, such as the occurrence of decubitus. Decubitus injury is a damaged tissue, anatomical injury, and skin burning due to lying in bed over a long period of time. Therefore, a tool is required to overcome the problem by monitoring and reducing the temperature between the patient's body and the bedding. This proposed tool works by monitoring when the temperature between the patient's body and the mattress is detected ? 33°C, the tool will automatically cool the surface of the bed so that it can reduce the temperature between the patient's body and the bed. The targeted comfortable temperature of bedding/mattress used by patients in the tropical climate (such as Indonesia) is around 33°C to 35°C at a room temperature of approximately 25°C to 27°C.
Generalized Procedure for Determining the Collision-Free Trajectory for a Robotic Arm
Authors: Al-Sharo Yasser Mohammad , Abu-Jassar Amer Tahseen , Sotnik Svitlana , Lyashenko Vyacheslav
Published: August 2023

Robotic systems play an important role in the development and modernization processes of production, facilitation of labor, and human life. The robotic manipulators are outstanding among such systems. Such robots can be used for various spheres of their application. In this case, there is the manipulator’s effective control problem in the working area, of which there may be various obstacles. Therefore, a procedure is required to find the optimal path for moving the robotic arm. To develop such a procedure, the literature was reviewed, and the structural diagram of the control system of such a robot and its components was summarized. It proposed a mathematical formalization of the search for the optimal path to move the robot arm, an algorithm based on a modified method of navigation graphs, to realize the more natural movement of the robot arm. Experimental studies were conducted with different numbers of objects on the path of robot arm movement, which were combined into groups. The temporal results of this process are presented in a diagram.
Legal essence of self-determination of a person and a citizen
Authors: Dostavalova Alena Sergeevna
Published: August 2023

the subject of the research is the definition of the social and legal essence of self-determination of a person and a citizen. An analysis of domestic doctrinal research on this subject made it possible to single out three aspects in understanding the self-determination of a person: determining one's behavior without the intervention of third parties, establishing one's status, and the possibility of obtaining information about oneself. Each of the presented concepts, denoted by the term "self-determination", has its own value and contributes to improving the quality of life of citizens. However, an incorrect understanding of the legal essence of self-determination can give rise to negative social consequences, which already has its manifestations in Russian society. As a result of the study, the conclusion was formulated that, contrary to the widespread opinions of legal scholars, the first aspect of self-determination is not a subjective right or part of it, but the embodiment of the principle of the inadmissibility of arbitrary interference by anyone in private affairs, the effect of which, in turn, is limited the principles of inadmissibility of abuse of the right, good faith of subjects of civil law and restriction of rights in order to protect the interests of other persons. The second aspect of self-determination is not a power, but a legal fact - a unilateral transaction, in the course of which it is necessary to take into account the requirements of the legislation on the conditions for its validity. The third aspect is not a personal non-property, but an organizational subjective right, the possibility of realizing which depends on the legitimacy of the goals of using the requested information by a citizen.
How Much Can Molecular Dynamics Improve over Harmonic Analysis on Vibrational Spectrum Predictions? Insights from Microcanonical Molecular Simulations of Anharmonic Water Clusters
Authors: Zhang Yuzhe , Wang Yiwen , Xu Xi , Chen Zehua , Yang Yang
Published: August 2023

Vibrational spectroscopy is widely used to gain insights into structural and dynamic properties of chemical, biological and material systems. Thus, an efficient and accurate method to simulate vibrational spectra is desired. In this Letter, we propose a microcanonical molecular simulation scheme for efficient calculations of vibrational spectra. Within the new scheme, we perform constrained nuclear-electronic orbital molecular dynamics simulations and accurately predict vibrational spectra of three challenging water clusters: neutral water dimer (H4O2), protonated water trimer (H7O3+) and protonated water tetramer (H9O4+). We find that in addition to nuclear quantum effects, vibrational mode coupling effects are also crucial for the accurate description of the vibrational motions of these highly anharmonic hydrogen bonded systems, which accounts for the large discrepancy between the vibrational frequencies obtained from molecular simulations and harmonic analyses.
Secondary Ion Mass Spectrometry of Single Giant Unilamellar Vesicles Reveals Compositional Variability
Authors: Grusky Dashiel , Bhattacharya Ahanjit , Boxer Steven
Published: August 2023

Giant unilamellar vesicles (GUVs) are a widely used model system to interrogate lipid phase behavior, study biomembrane mechanics, reconstitute membrane proteins, and provide a chassis for synthetic cells. It is generally assumed that the composition of individual GUVs is the same as the nominal stock composition, however, there may be significant compositional variability between individual GUVs. Although this compositional heterogeneity likely impacts phase behavior, the function and incorporation of membrane proteins, and the encapsulation of biochemical reactions, it has yet to be directly quantified. To assess heterogeneity, we use secondary ion mass spectrometry (SIMS) to probe the composition of individual GUVs using non-perturbing isotopic labels. Both 13C- and 2H-labeled lipids are incorporated into a ternary mixture, which is then used to produce GUVs via gentle hydration or electroformation. Simultaneous detection of seven different ion species via SIMS allows for the concentration of 13C- and 2H-labeled lipids in single GUVs to be quantified using calibration curves, which correlate ion intensity to composition. Additionally, the relative concentration of 13C- and 2H-labeled lipids is assessed for each GUV via the ion ratio 2H-/13C-, which is highly sensitive to compositional differences between individual GUVs and circumvents the need for calibration using standards. Both quantification methods suggest that gentle hydration produces GUVs with greater compositional variability than those formed by electroformation. However, both gentle hydration and electroformation display compositional variability on the order of 5-15 mol percent.
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small Molecule Inhibitors
Authors: Buchholz Caroline , Sneddon Molly , McPherson Joseph , Das Sourav , Gee Clifford , Grillo Michael , Chai Sergio , Lee Richard , Chen Taosheng , Harki Dan , Shelat Anang , Pomerantz William
Published: August 2023

Methyl lysine readers, specifically PHD fingers, are emerging epigenetic targets in human diseases. For example, several PHD finger fusions are implicated in clinical cases of acute myeloid leukemia, highlighting the potential for PHD inhibitors in disease regulation. However, limited chemical matter exists targeting PHD fingers. Here we report the first fragment-based screen against the BPTF PHD to identify several of the first reported BPTF PHD-targeting small molecule ligands. We used ligand-observed NMR to first screen a fragment library, followed by biophysical validation to prioritize two scaffolds, pyr-rolidine- and pyridazine-containing fragments. Structural predictions show these respective scaffolds may engage two distinct subpockets on the protein. The demonstrated ligandability of the BPTF PHD supports the future development of methyl lysine reader chemical probes to study their oncogenic functions.
Step-by-step : A microfluidic (PDMS) staircase device for size sorting microparticles down to 25 µm using a 3D-printed mold
Authors: Velders Aldrik H. , van Lieshout Lisette , Brienen Erik A. T. , Diederich Benedict , saggiomo vittorio
Published: August 2023

Microparticles are ubiquitous and span from living matter to microplastics to inorganic materials. Their detection and identification must be more accessible and time efficient. Microfluidic devices can filter microparticles from liquids, but fabricating microfluidics with lateral resolutions of a few tens of microns is complex, lengthy, and outside the reach of most scientists researching microparticles. In this article, we show how to use height features in a channel instead of relying on lateral elements for separating particles. The height features can be as small as 25 µm, along the Z axis, using consumer-grade 3D printers. We show the potential of such microfluidic devices for size-sorting parasite eggs such as Schistosoma haematobium, microplastics, and zooplankton.
Second Order Saddle Points Dictate the Products of Electrocylic Reactions
Authors: Mirzanejad Amir , Muechler Lukas
Published: August 2023

The conventional understanding of chemical reactions, primarily focused on one-dimensional minimum energy pathways, has been expanded in recent years to include phenomena like second order saddle points or bifurcations. In this study, we explore these intricacies within the context of electrocyclizations and present a novel approach that moves beyond the traditional view of activation barriers, revealing that second order saddle points are crucial in dictating the competition between disrotatory and conrotatory pathways. Our findings suggest opportunities to manipulate the competition between conrotatory and disrotatory pathways through geometric constraints, fundamentally altering the connectivity of the potential energy surface. Through the development of a minimal model Hamiltonian, we illustrate the generality of our findings and highlight the importance of the multi-reference nature of states near the second order saddle point. This study emphasizes the necessity of multi-reference methods and the need to conduct higher-dimensional explorations for competing pathways. It opens new avenues for systematic control of selectivity in electrocyclic reactions and offers a rich perspective on the complex interplay of steric considerations and electronic correlations.
Discriminating Extra Virgin Olive Oils from Common Edible Oils: Comparable Performance of PLS-DA Models Trained on Low-Field and High-Field 1H NMR Data
Authors: Head Thomas , Giebelhaus Ryland , Nam Seo Lin , de la Mata A. Paulina , Harynuk James , Shipley Paul
Published: August 2023

Olive oil, the oil derived from the olive tree (Olea europaea L.), is used in cooking, cosmetics, and soap production. Due to its high value, some producers adulterate olive oil with cheaper edible oils or mislabel cheaper oils to increase profitability. These other edible oils can have chemical profiles similar to extra virgin olive oil but can cause allergies in sensitive individuals. Given these consequences, there is a need for methods to rapidly authenticate olive oils. Nuclear magnetic resonance (NMR) has been used for this purpose, as it requires minimal sample preparation and is non-destructive. By utilizing NMR spectra of the samples and machine learning models trained on known olive oil and edible oils, oil samples can be classified and authenticated. While high-field NMRs are commonly used due to their superior resolution and sensitivity, they are generally prohibitively expensive to purchase and operate, for routine screening purposes. Low-field benchtop NMR presents an affordable alternative. Here, we compared the predictive performance of partial least squares discrimination analysis (PLS-DA) models trained on low-field 60 MHz benchtop 1H NMR and high-field 400 MHz 1H NMR spectra. We demonstrated that PLS-DA models trained on low-field spectra perform comparably to those trained on high-field spectra.
Experimental design and re-parameterization of the Neue-Kuss model for accurate and precise prediction of isocratic retention factors from gradient measurements in reversed phase liquid chromatography
Authors: Rutan Sarah , Cash Kathryn , Stoll II Dwight
Published: August 2023

The present work describes a re-parameterization of the Neue Kuss (NK) model for describing retention in liquid chromatography, and this re-parameterized model is used fit a large set of isocratic retention measurements with improved convergence properties relative to the original parameterization of the model. Next, an experimental design for retention measurements made using mobile phase gradient elution conditions is proposed for the purpose of obtaining accurate and precise NK parameters. Simulated retention data for mobile phase gradient elution conditions with two different levels of noise, as well as an essentially zero noise level were fit with the re-parameterized model. The results showed that the re-parameterized fits yielded average (absolute value) prediction errors for the parameters at the highest noise level of 7.16 % for S1,ref, 17.5 % for S2,ref and 6.19 % for kref. These errors were significantly smaller than those for the original parameterization of the NK model, where the errors were 23.2 % for S1, 24.9 % for S2 and 159 % for kw. Furthermore, isocratic retention factors predicted using these model parameters were found to have an average magnitude of error of 0.509 % for the re-parameterized model, as opposed to 6750 % for the model with the original parameterization. A further test of this approach was carried out for independent experimental measurements for five solutes and a C18 column. The average magnitude of error of the isocratic retention factors predicted from parameters obtained from fits of gradient data was 1.59 %, provided that the range of organic solvent compositions that the solute sampled in the mobile phase gradient experiments was consistent with the isocratic experiments. These results indicate that the reparameterization of the NK model allows for significant improvements in the fitting process, and that the proposed experimental design allows for NK parameters to be extracted from mobile phase gradients experiment that predict isocratic retention factors with an accuracy on the order of 1%.
Prediction of Absolute Protein-Protein Binding Free Energy by a Super Learner Model
Authors: Chaves Elton , Mhrous Emmanuel , Nascimento-Filho Manasses , Cruz Carlos , Ferraz Matheus , Lins Roberto
Published: August 2023

Predicting the strength of protein-protein association allows for understanding the molecular mechanisms, and ultimately controlling it. We devised a novel model to predict protein-protein binding free energies. A machine learning ensemble algorithm uses Rosetta-based quantities to predict binding free energies with unprecedented accuracy, rivaling the most computationally demanding methods available.
Analisis Faktor Kesuksesan Aplikasi HRIS Mobile Menggunakan Model Delone And Mclean
Authors: Kusuma Putra Marcellinno , Farisi Ahmad
Published: August 2023

Penelitian ini bertujuan untuk menganalisis faktor kesuksesan aplikasi Human Resource Information System (HRIS) berbasis mobile di PT Penerbit Erlangga Cabang Palembang. Penelitian ini menggunakan Model Delone and Mclean sebagai kerangka analisis. Metode penelitian yang digunakan adalah survei dengan kuesioner sebagai instrumen pengumpulan data. Responden dalam penelitian ini adalah karyawan PT Penerbit Erlangga Cabang Palembang yang telah menggunakan aplikasi HRIS mobile. Data yang terkumpul kemudian dianalisis dengan menggunakan aplikasi SmartPLS untuk mengevaluasi hubungan antara faktor-faktor dalam model Delone and Mclean dan keberhasilan aplikasi HRIS mobile. Hasil penelitian menunjukkan bahwa faktor-faktor seperti kualitas sistem, kualitas informasi, kepuasan pengguna, dan manfaat yang dirasakan oleh pengguna berkontribusi secara signifikan terhadap keberhasilan aplikasi HRIS mobile. Kualitas sistem dan kualitas informasi menjadi faktor kunci dalam mencapai keberhasilan aplikasi HRIS mobile di PT Penerbit Erlangga Cabang Palembang.
The Characterization of Prokaryotic Diversity in Lake Beyşehir Using a 16s Metagenomics Study
Authors: Pat Fahri , Fidan Pedük Sultan , Akçay Neşe , Kızıl Pat Hatice Kübra , Arıcan Ercan
Published: August 2023

Lake Beysehir, located in the Central Anatolia Region, is the biggest lake in Central Anatolia, providing drinking water and irrigation. It is Turkey's third-largest lake and the largest freshwater lake. Its waters are fresh water and its depth is around 8-9 m at most. The deepest point is mentioned as 12, 14, and 15 m in different sources. Although there is a lake used by such a large population in our country, there are not enough studies on microbial diversity, so revealing the diversity is important for the lake and the population around the lake.
Next-generation sequencing (NGS) research has made it possible to sequence RNA and DNA considerably quicker and cheaply than in by assessing the PCR amplicon, we utilized NGS high-throughput methods for the metagenomic research of Lake Beyşehir sequences of 16S rDNA (regions V3–V4). The analyzes revealed the phylum Proteobacteria, Verrucomicrobia, Bacteroidetes and Actinobacteria.
Historical Arch Bridges-Deterioration and Restoration Techniques
Authors: Bagherzadeh Azar Amin , Sari Ali
Published: August 2023

Historic buildings are the most valuable evidence of cultural heritage. They play an essential role in establishing a tangible link between the past and the present by understanding, interpreting, and tracing the epoch of civilization. Unfortunately, the high costs of restoration, vandalism, and arson take their toll. However, new technologies are having a positive impact on the restoration process and are becoming a suitable alternative to labor-intensive, expensive, and unsafe traditional inspections. Therefore, the role of non-destructive testing (NDT) as a new method is becoming more evident. Faro laser scanning, impact echo, impulse sound testing, and geoelectric tomography as non-destructive methods are leading to the inspection of historic structures to preserve their character. These new methods are representative of the development of non-contact techniques for the examination and documentation of structures. Non-destructive testing examines the internal and external structure of complex building components as well as defective areas, quantifies cracks, and detects near-surface moisture. The objective of this work is to identify new adventurous and traditional methods for the reconstruction of the Turkish arch bridges Dara-1 and Halilviran to determine the appropriate rehabilitation methods and their deterioration of construction materials, damage, and failure patterns. Bridge dimensions were measured using a Faro laser scanner, which allows inspectors to capture and evaluate data from bridges and structural components without permanently altering them. The laser captures bridge dimensions by scanning cross-sections of the structure in the horizontal and vertical planes. The data is exported in the form of point clouds that represent all visible aspects and actual dimensions of the bridge in 2D and 3D models. In comparison between traditional and laser scanning methods, the main advantages of the applied method are the time savings on-site and the creation of a three-dimensional model of the structure, which can be used to collect precise and accurate surface data of objects in a non-destructive manner. Doi: 10.28991/CEJ-2023-09-07-010 Full Text: PDF