bluuebunny/crossref_metadata_2025 huggingface dataset:
Hacia una agenda de políticas públicas para el desarrollo local
Authors: Canto Sáenz Rodolfo Armando
Published: April 2020

a agenda de políticas públicas para el desarrollo local o endógeno es cada vez más amplia y compleja, hecho que en sí mismo da cuenta del creciente involucramiento de los gobiernos y las sociedades locales en la promoción del desarrollo. La agenda de políticas públicas para el desarrollo local incluye al menos los siguientes tópicos: Cohesión Social, Sostenibilidad, Competitividad, Construcción de Ciudadanía y Estado, Capital Social y Responsabilidad Social; el artículo se refiere brevemente a cada uno de ellos. Debe reconocerse que el desarrollo es complejo y multidimensional y que, por esto mismo, es necesario evitar los reduccionismos que tienden a identificarlo con una o unas pocas de sus dimensiones. La construcción de una agenda eficaz del desarrollo local no puede ser sino participativa, de otro modo tenderá a incluir sólo las prioridades de los poderes establecidos, sean institucionales o fácticos. La amplia participación de la sociedad civil es imprescindible para garantizar la multidimensionalidad de los objetivos del desarrollo.
Microsurgical clipping of paraclinoid aneurysms
Authors: Radoi Mugurel , Vakilnejad Ram , Stefan Suditu , Stefanescu Florin
Published: April 2020

Background. Paraclinoid aneurysm is a nonspecific term that includes ophthalmic segment aneurysms and distal cavernous internal carotid artery (ICA) aneurysms. The literature mostly described the frequency to be in the range of 1.3-5%. and a high incidence of being multiple or having a large size.

Methods. A retrospective review of 18 consecutive patients surgically treated for paraclinoid aneurysm was performed. The data of all our consecutive patients were searched to obtain patient and aneurysm characteristics, treatment details, complications and follow up. Clinical outcome was graded according to the modified Rankin scale. The follow-up period varied widely from 3 to 62 months (mean 26 months).

Results. Surgical clipping was performed for 15 ruptured paraclinoid aneurysms; only in 3 cases the aneurysm was unruptured. Post-operative control angiography was performed in 10 patients (55.56%), from which we reported a full occlusion of the aneurysm in 9 patients (90%). Best results were obtained in patients who preoperatively were included in 1st and 2nd grade of Hunt & Hess scale. Two months postoperative follow-up was complete for all but one patient who died 12 days after surgery, from cerebral ischemia resulting from severe cerebral vasospasm. There were excellent and good results (mRS 0–2) in 88% of the cases (15 out of 17 patients) at two months follow-up, and 94% (16 out of 17 patients) at six months follow-up. Three patients with slight disabilities, ranked mRS 1-2 at two months follow-up, improved to mRS 0, with no symptoms at all, at 6 months postoperative control. All 3 patients with a surgically treated non-ruptured paraclinoid aneurysm had an excellent outcome (mRS 0).

Conclusions. Most appropriate treatment is to occlude aneurysms without compromising patency of the parent artery. Anterior clinoidectomy and microsurgical clipping can still be a standard treatment despite of recent development of endovascular coiling procedures.
Spinal intramedullary cysticercosis mimicking spinal tumour
Authors: Ansari Ahmed , Agrawal Sheshank , Riyaz Sadaf
Published: April 2020

Neurocysticercosis is a relatively uncommon entity with even more rare spinal intramedullary variety. We present a case of cervico- dorsal intramedullary NCC mimicking spinal tumour with per operative finding mimicking abscess.
Computed tomography-based morphometric measurements of the atlas (C1) posterior arc
Authors: Karatas Yasar , Kaya Bulent , Erdi Mehmet Fatih , Keskin Fatih , Arac Densel , Izci Emir Kaan , Uyar Mehmet , Kıvrak Ali Sami , Kalkan Erdal
Published: April 2020

Study design: Single-center retrospective study

Objectives: This study is performed to determine the anatomic feasibility of the C1 posterior arc screw and help select an optimal screw trajectory in treating patients with craniovertebral junction pathologies.

Material and Methods: We reported a single-centre retrospective study. Forty patients (20 male and 20 female) who underwent cervical computed tomography (CT) were chosen from the hospital records. Based on CT images, we measured left laminar length (LLL), right laminar length (RLL), left laminar angle (LLA), right laminar angle (RLA), left laminar axial thickness (LLAT), right laminar axial thickness (RLAT), left laminar coronal thickness (LLCT), right laminar coronal thickness (RLCT), and craniocaudal angle (CCA) of the C1 posterior arc.

Results: The mean values and standard deviations (SD) for nine parameters at the C1 posterior arc were determined. LLL, RLL, LLCT, and RLCT were statistically longer in men than women. RLAT was bigger in men but there was no statistical difference. RLA was statistically wider in women than men. LLA and CCA were wider in women but there was no statistical difference, LLAT was bigger in women but there was no statistical difference. There was no statistical difference in measurements by age.

Conclusion:  The results of this study are important to avoid neurovascular injury and pedicle breakage because of choosing large screw while performing C1 laminar screw fixation.
Intraventricular arachnoid cyst of lateral ventricle in an elderly patient
Authors: Misra Rajneesh , Kumar Sushil , Sharma Sandeep , Bharadva Pankaj
Published: April 2020

Arachnoid cysts are usually located in relation to the arachnoid cisterns. Intra-ventricular location is rare and its embryological emergence in this site is controversial. We report a large intra-ventricular cyst in a 61-year-old female who presented with decreased vision, headache and right hemiparesis. MRI was suggestive of cystic lesion in the lateral ventricle and was excised completely through a craniotomy.
Lumbar unilateral laminotomy for bilateral decompression in lumbar spinal stenosis
Authors: Sabry Amin , Zakarya Wael , Khalil Amr Farid
Published: April 2020

Background: Multiple surgical approaches are existing for the management of lumbar canal stenosis.Objective: This study was conducted to assess the outcomes of unilateral laminotomy with bilateral decompression in such cases.Patients and methods: This prospective study was conducted at Mansoura University Hospitals, and we included a total of 12 cases with lumbar canal stenosis. All cases underwent unilateral laminotomy with bilateral canal decompression during the period between July 2017 and July 2018. Post-operative outcomes included ODI, and VAS score for both leg and back pain.Results: The age of the cases ranged between 38 and 62 years. We included 7 males and 5 females. ODI, lower extremity, and back pain showed a significant decrease after the operation (p < 0.05).Conclusion: Unilateral laminotomy with bilateral canal decompression is a safe and feasible approach to managing LSS. Excellent outcomes are expected regarding leg pain and quality of life, while slight improvement is anticipated regarding low back pain.
Caracterización de los efectos el desarrollo de plantas de cacao (Theobroma cacao) en vivero
Authors: Enríquez Jaramillo Freddy , Castro Cristian , Jiménez Pozo Patricio
Published: April 2020

El estudio tuvo como iniciativa, evaluar el efecto de los fertilizantes de liberación controlada sobre el desarrollo de plantas de cacao en fase de vivero. Para así, contribuir a dar una alternativa de manejo sostenible de la nutrición en plantas de cacao en vivero. Se utilizó un Diseño de Bloques Completos al Azar (DBCA), con cuatro repeticiones por cada tratamiento. Para la comparación de medias de tratamientos se empleó la prueba de Tukey al 5% de significancia para tratamientos, tipos y dosis de fertilizantes. Se realizaron polinomios ortogonales entre “Dosis” de cada uno de los fertilizantes a utilizar. La aplicación en dosis bajas de los FLC resultaron ser de mayor beneficio económico. Iyer et. al., (2002) y Erro et. al, (2007), mencionan que los FLC pueden disminuir el impacto ambiental por lixiviación o volatilización de elementos nutritivos y, dada su relación costo-eficiencia, también son económicamente rentables en muchos cultivos.
Evaluación de la aclimatación y rendimiento de 20 cultivares de brócoli (Brassica oleracea L. Var. Itálica.), a campo abierto
Authors: Parra Morocho Cristian M. , Hidalgo Luis
Published: April 2020

El presente artículo muestra la evaluación de la aclimatación y rendimiento de 20 cultivares de brócoli (Brassica oleracea L. Var Itálica.), en Guayllabamba, Cantón Chambo, Provincia de Chimborazo; la metodología utilizada fue ADEVA del diseño de Bloques Completos al Azar (BCA), estableciendo parcelas con 20 cultivares de brócoli y tres repeticiones. Los cultivares que mejor se aclimataron a las condiciones de Guayllabamba fueron Interoc 010 (T17), Interoc 006 (T14), Hot Bro (T8), y Avenger (T19) por sus características morfológicas y fisiológicas.; Interoc 010 (T17) e Interoc 006 (T14) presentaron la mayor altura de planta con 91,18 cm y 85,74 cm respectivamente, el mayor número de hojas presentaron los cultivares Interoc 001 (T11) e Interoc 006 (T14) con 17,67 y 17,63 hojas; para número de días a inicio de la cosecha Hot Bro (T8) fue el cultivar más precoz con 78 días y Steel (T18) se consideró como un cultivar tardío con 84,33 días; los mayores diámetros de pella presentaron los cultivares Legacy (T20) e Interoc 001 (T11) con 18,08 y 17,87 cm respectivamente; las mejores características de la pella (forma, compactación, granulometría y color) presentaron los cultivares 25-455 (T2), Interoc 010 (T17), Avenger (T19) y Legacy (T20); los mayores rendimientos en campo por ha presentaron los cultivares Hot Bro (T8) e Interoc 010 (T17), con 37390 kg y 37220 kg respectivamente y en agroindustria los cultivares Interoc 010 (T17), Avenger (T19) con 25870 kg y 25390 kg respectivamente; para el rendimiento industrial procesado los mejores cultivares fueron Interoc 009 (T16) e Interoc 001 (T11) con 75,24 % y 74,37% respectivamente; económicamente el cultivar Interoc 010 (T17) presentó el mayor beneficio neto por hectárea con 4353, 89 USD y una tasa de retorno marginal de 1513,94 %.
Correlación entre la conductividad eléctrica medida en el extracto de saturación del suelo y en extractos con cinco relaciones sueloagua
Authors: Gutiérrez R Edgar , Cáceres C. Alfredo
Published: April 2020

El artículo que se presenta a continuación tiene por objeto determinar si los datos de salinidad obtenidos en los extractos de saturación tienen una correlación adecuada con las respectivas suspensiones, en suelos de cinco zonas del Departamento de Cochabamba. El método empleado estuvo constituido por las muestras de suelos que se tomaron en cinco localidades de Cochabamba (Imagen 1), para posteriormente caracterizar sus propiedades físicas y químicas en el Laboratorio de Suelos y Aguas de la F.C.A. P y V. de la UMSS. Parte de los resultados arrojados fue las determinaciones de pH y C.E., se obtuvieron en suspensión con una relación agua-suelo de 1:1; 1:2; 1:2.5; 1:5 y 1:10 y Extracto de Saturación, cuyos valores se muestran en los cuadros posteriores. Para finalizar se tiene que los suelos caracterizados tienen presencia de sales, cuyos valores de pH, varían desde 8.0 hasta 8.9 (para las localidades de La Tamborada y Villa Rivero, respectivamente.
Absorción de nitrógeno durante el desarrollo del cultivo de cebada maltera (Hordeum vulgare L.) Variedad metcalfe. Imbabura
Authors: Albán M. Daniela , Calvache U. Marcelo , Garófalo S. Javier
Published: April 2020

La investigación planteó desarrollar una tecnología adecuada para el manejo de la fertilización nitrogenada complementaria en cebada cervecera mediante un estudio de absorción de nitrógeno. Esta investigación se desarrolló en la provincia de Imbabura, Los métodos usados fueron los experimentos se establecieron en la Hcda. Cobuendo (2340 msnm) ubicada en el cantón Antonio Ante y en la Hcda. Pisangacho (2700 msnm) situada en el cantón Urcuquí. Como resultado se obtuvo que el estudio de absorción de nitrógeno realizado en la localidad de Cobuendo, permitió mostrar que la acumulación de nitrógeno en la biomasa aérea total en función del tiempo, presentó una tendencia sigmoidea típica. La acumulación de nitrógeno en la biomasa aérea total se ajustó a una regresión logística normal.
Depression and the Effect of Sertraline on Inflammatory Biomarkers in Patients with Nondialysis CKD
Authors: Gregg L. Parker , Carmody Thomas , Le Dustin , Bharadwaj Nina , Trivedi Madhukar H. , Hedayati S. Susan
Published: April 2020

Background

Inflammatory biomarkers are elevated in patients with CKD and associated with poor outcomes. Major depressive disorder (MDD) is prevalent in CKD and associated with inflammation. No studies investigated the effect of MDD treatment on plasma inflammatory biomarkers in patients with nondialysis CKD.

Methods

In a prespecified analysis of the randomized, double-blind CKD Antidepressant Sertraline Trial, we investigated whether treatment with sertraline versus placebo or response to treatment would affect plasma levels of albumin, prealbumin, IL-6, and high-sensitivity C-reactive protein (hsCRP), measured at baseline and after 12 weeks of treatment. We also explored whether somatic versus nonsomatic depressive symptoms, measured using the Quick Inventory of Depressive Symptomatology, and quality-of-life subscales, measured using the Kidney Disease Quality of Life Short Form, were associated with baseline levels of these inflammatory biomarkers.

Results

Of the 193 participants, mean age was 58.4 (SD 13) years and 58% were black, 42% were white, and 18% were Hispanic. Higher baseline hsCRP correlated with somatic depressive symptoms (r=0.21; P=0.01), fatigue (r=0.22; P=0.005), and poorer physical functioning (r=−0.26; P=0.001). There was no change in hsCRP in the sertraline group. hsCRP increased in placebo nonresponders from baseline (median, 3.7 mg/L; interquartile range [IQR], 1.7–10.0 mg/L) to exit (median, 4.9 mg/L; IQR, 1.8–8.8 mg/L; P=0.01). The change from baseline to exit differed between placebo responders (median, −0.4 mg/L; IQR, −9.3 to 0.2 mg/L) and nonresponders (median, 0.8 mg/L; IQR, −0.1 to 3.9 mg/L; P=0.008). There were no differences in changes in albumin, prealbumin, or IL-6 from baseline in any group.

Conclusions

Among patients with CKD and MDD, hsCRP correlated with somatic symptoms of depression and fatigue, but not with nonsomatic symptoms. Sertraline treatment was not associated with a longitudinal change in hsCRP from baseline regardless of treatment effect on depressive symptoms, but those who failed to respond to placebo had an increase in hsCRP over time. This area deserves further investigation.

Clinical Trial registry name and registration number:

CKD Antidepressant Sertraline Trial (CAST), NCT00946998.
Varoluşçuluğun Türk Edebiyatında Algılanışı ve Tutunamayanlar
Authors: ŞAHİN Yunus
Published: April 2020

Varoluşçuluğun bir akım hâline gelmesinde edebiyat önemli bir konuma sahiptir. Nitekim Albert Camus ve Jean Paul Sartre gibi varoluşçu düşünürler fikirlerini edebi eserler üzerinden açıklama gereği duymuşlardır. Böylece “varoluşçu edebiyat” olarak adlandırabileceğimiz bir kavram ortaya çıkmıştır. Varoluşçular genel manada sanayileşme, modernizm ve II. Dünya Savaşı gibi büyük toplumsal etkilere neden olan olgu ve olaylar karşısında bunalan insanı konu almışlardır.
Türk Edebiyatında varoluşçuluğun etkileri 1950’li yıllarda görülmeye başlanmıştır. Batılı yazarların eserleri ile benzerlikler göstermelerine rağmen Türk Edebiyatında varoluşçuluğun dayandığı temel ilkelerin aynı olduğu söylenemez. Zira Türk toplumu Sanayi Devrimi ve II. Dünya Savaşı gibi toplumsal olayların etkisini doğrudan hissetmemiştir. Türk Edebiyatında bunların yerini kültür karmaşasının yarattığı bunalım almıştır. Oğuz Atay, Türk Edebiyatında bunalan aydın bireyi konu edinen en önemli yazarlardan biridir. Bu çalışmada Türk Edebiyatında varoluşçuluğun nasıl algılandığı, Batı edebiyatına göre benzerlik ve farkları ve bu bağlamda Oğuz Atay’ın varoluşçu edebiyat içerisindeki konumu Tutunamayanlar romanı üzerinden incelenecektir. Böylece bir felsefî disiplin olarak varoluşçuluğun, Türk edebiyatı için nasıl bir zemin ve çerçeve sunduğu sorusu cevaplanmaya çalışılacaktır.
Mustafa Çiftci'nin Öykülerinde Evliliğe Bakış
Authors: ERDÖL Gültuğ
Published: April 2020

İnsana ait en güçlü ve en güzel duygulardan biri olan aşk, Türk Edebiyatı’nın birçok eserine konu olmuştur. Aşk, Divan Edebiyatı ve Halk Edebiyatı eserlerinde âşıkların kavuşamadığı ölçüde değerli olurken, modern edebiyatla birlikte; iyi, kötü, güzel, çirkin tüm yönleriyle eserlerde kendisine yer bulmuş ve toplumsal hayatta karşımıza çıkan tüm yönleri ile edebiyat içerisinde de değerlendirilmeye başlanmıştır. Aşk sonucu ortaya çıkan en önemli olgu ise evlilik kavramıdır.
Birbirine aşk ve sevgi bağıyla bağlı erkek ve kadının, bu sevgi sonucu kalan hayatlarını bir arada geçirme isteği olarak tanımlayabileceğimiz evlilik akdi, karşılıklı sevgi ve iki kişinin de isteği neticesinde gerçekleşen yahut gerçekleşmesi gereken bir eylemdir. Ancak hem toplumumuzda hem de dünyada birçok evliliğin, her iki kişinin ya da taraflardan birinin rızası olmadan gerçekleştiği görülür. Bazı kişiler ise ailevi, toplumsal ya da sosyo kültürel nedenlerden ötürü sevdikleri kişi ile evlenememektedir. İnceleyeceğimiz Mustafa Çiftci öykülerinde de odak noktasında aşk olmayan ve farklı sebeplerle gerçekleştirilen evliliklere değinilecektir.
Ali Paşazâde Mustafa Hamdî ve Dîvânı
Authors: YILDIZ Enes
Published: April 2020

Yaklaşık altı yüz yıl devam eden Klasik Türk edebiyatının bugünkü nesillere bıraktığı edebî mirasların başında dîvânlar gelmektedir. Bugüne kadar yüzlerce dîvân üzerine çalışmalar yapılmış ve yapılmaya devam etmektedir. Dîvân şiiri geleneğinde yetişen sanatçılardan biri de bu çalışmaya konu olan XVIII. yüzyıl şairlerinden Ali Paşazâde Mustafa Hamdî’dir. Mustafa Hamdî Bey 1180 (1766-1767) yılında doğmuştur. Yegen Ali Paşazâde Hamdî’nin asıl adı Mustafa’dır. Mustafa Kâ’il Efendi’den Arapça ve Farsça dersler alan Hamdî, 1207 (1792-1793) yılında 27 yaşındayken vefat etmiştir. Şu an için bilinen tek eseri ise Dîvân’ıdır. Dîvân’ın ulaşabildiğimiz tek nüshası ise Medine Ârif Hikmet Kütüphanesi Türkçe Yazmalar 205/811 arşiv numarasıyla kayıtlıdır. 30 varaktan oluşan Dîvân’da sırasıyla 102 gazel, 1 müseddes, 1 tahmis, 11 kıt’a, 1 kaside ve 8 müfred olmak üzere toplam 124 şiir bulunmaktadır. Çalışmada öncelikle şair hakkında kaynaklardan elde edilen bilgiler verilecek, ardından Hamdî’nin bilinen tek eseri olan Dîvân tanıtılacaktır. Yazının sonunda Dîvân’dan seçilen örnek şiirlerin transkripsiyonlu metni verilecektir.
Imagen impersonal y ninfa posthumana. Lecturas "nietzscheanas" de Warburg
Authors: Fleisner Paula
Published: April 2020

Este trabajo analiza tres interpretaciones del pensamiento de Warburg que buscan volver a pensar los elementos que los discípulos inmediatos de Warburg debieron dejar de lado para construir una iconología como “ciencia humanista”: la “vida” en el concepto de Nachleben, el “pathos” en el de Pathosformel y una cierta interpretación de la ninfa como devenir inhumano del cuerpo femenino. Es decir, por un lado, se estudian los planteos agambenianos en torno al carácter polar, no dicotómico, de las fórmulas del pathos y su relación con la vida póstuma (simultáneamente fisiológica e histórica) de las imágenes; lo que permitiría pensar el arte como un modo de hacer que conserva y transforma el espacio a-subjetivo de las emociones en una experiencia de lo impersonal. Por otro lado, se examinan las consideraciones didi-hubermanianas en torno al modo de existencia (Lebensformen) involucrado en la supervivencia de las imágenes, entendido como un juego impuro de latencias y violencias, alejado de la estética moderna del gusto. Y, finalmente, a partir de la lectura de Paskaleva, se busca pensar la figura de la ninfa por fuera de su reducción a un objeto de deseo masculino como esquema de una expresión de afectividad ya no humana.
El cuerpo de la imagen y la locura en Aby Warburg. Una reflexión a partir de fuentes renacentistas
Authors: Ludueña Romandini Fabián
Published: April 2020

El presente artículo tiene como propósito interrogarse sobre la matriz conceptual según la cual Aby Warburg interpretó tanto El Nacimiento de la Primavera como la Primavera de Sandro Botticelli. Por un lado, proponemos un análisis del papel desempeñado por la poesía del dolce stil nuovo y el neoplatonismo en la comprensión warburguiana de las alegorías de Botticelli. Por otro lado, intentamos dar cuenta de la significación filosófica de la hipótesis explicativa de Warburg a través de un estudio del comentario de Marsilio Ficino al poema Donna me prega de Guido Cavalcanti. La interpretación de Ficino toma como base la noción de spiritus y la desubjetivación de los amantes en beneficio de las potencias cosmológicas. De esta manera, la forclusión del cuerpo resulta la condición de posibilidad del fantasma como auténtico objeto de deseo. Esta interpretación es sancionada por la original apropiación de Ficino de la teoría platónica de las dos Venus (celestial y vulgar). Finalmente, avanzamos la hipótesis según la cual la escisión de las dos Venus en la tradición neoplatónica marca un hito en la historia de la metafísica y juega un papel preponderante en la comprensión que Warburg tendrá de su propio período de internación psiquiátrica en Kreuzlingen desde 1921 a 1924.
Aby Warburg: El arte como política de la vida
Authors: Ulm Hernán
Published: April 2020

Este artículo intenta un abordaje integral de la obra de Warburg para mostrar que, más allá de las contrariedades que forman parte de la Historia del Arte, la propuesta del investigador alemán, dirigida a la elaboración de una “memoria de las imágenes”, tiene por objetivo final construir una definición de arte entendida como “política de la vida”. El artículo quiere mostrar de este modo que el pensamiento warburguiano adquiere su relevancia actual en la medida en que ofrece elementos para pensar los devenires contemporáneos alrededor de las imágenes. Si el presente es un “combate” de imágenes, la iconología presenta una heurística que nos permite comprender los sentidos y posibilidades inscriptas en tal combate.
La máquina óptica. Antropología del fantasma y (extra) ontología de la imaginación, de Germán Osvaldo Prósperi
Authors: Rosenzweig Esteban Miguel
Published: April 2020

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The absence of legal remedies following academic bullying
Authors: Mahmoudi Morteza , Moss Sherry
Published: April 2020

Currently, victims of discrimination and sexual harassment have institutional reporting systems and legal remedies which support them in finding justice for these crimes. However, victims of academic bullying, who suffer similar repercussions, have no legal or institutional remedies. Because academic bullying is not a crime, targets often suffer in silence because there is no recourse. It is time for institutions to ask for governmental support to create legislation, similar to that for sexual harassment and discrimination, which will bring justice to academic bullies and relief to their victims. In the absence of legislation, institutions should create reporting procedures and educational programs which mirror those they have in place for sexual harassment and discrimination.
Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori
Authors: Maleki-Kakelar Hadi , Dehghani Jaber , Barzegari Abolfazl , Barar Jaleh , Shirmohamadi Masoud , Sadeghi Javid , Omidi Yadollah
Published: April 2020

Introduction:
Gastric cancer is considered the second prevalent cause of death around the world. This type of cancer is generally induced by Helicobacter pylori which could colonize within the gastric mucosa of the infected cases. To date, triple antibiotic therapy has routinely been utilized for controlling the H. pylori-induced infection. However, this strategy has been unsuccessful, in large part because of issues such as occurring point mutations in the H. pylori genome that can induce resistance to the antibiotics administered. Recently, it has been shown that different probiotics may have strong anti-cancer effects, in which they are capable of inhibiting H. pylori by both immunological and non-immunological mechanisms. Here, we aimed at finding possible anti-cancer impacts of the probiotic bacterium Lactobacillus plantarum on gastric cancer, AGS cells. Methods: The anti-cancer effects of the conditioned media of the locally isolated L. plantarum on the AGS cells were evaluated by different analyses such as flow cytometry, DNA ladder assay, DAPI staining, and RT-PCR. Results: Our findings showed that the conditioned media of L. plantarum can inhibit both H. pylori and AGS cells through up-/down-regulation of PTEN, Bax, TLR4, and AKT genes. The exudates of the probiotic L. plantarum bacteria can increase the expression of PTEN, Bax, and TLR4, and also decrease the expression of AKT gene. Conclusion: In agreement with different reports, our results proved the anti-cancer effects of the locally isolated L. plantarum through some immunological cell signaling pathways. Accordingly, it seems the probiotics could be considered as at least a complementary treatment for different types of malignancies.
Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations
Authors: Khoramgah Maryam Sadat , Ranjbari Javad , Abbaszadeh Hojjat-Allah , Tabatabaei Mirakabad Fatemeh Sadat , Hatami Shadie , Hosseinzadeh Simzar , Ghanbarian Hossein
Published: April 2020

Introduction:
Simulating hydrophobic-hydrophilic composite face with hierarchical porous and fibrous architectures of bone extracellular matrix (ECM) is a key aspect in bone tissue engineering. This study focused on the fabrication of new three-dimensional (3D) scaffolds containing polytetrafluoroethylene (PTFE), and polyvinyl alcohol (PVA), with and without graphene oxide (GO) nanoparticles using the chemical cross-linking and freeze-drying methods for bone tissue application. The effects of GO on physicochemical features and osteoinduction properties of the scaffolds were evaluated through an in vitro study. Methods: After synthesizing the GO nanoparticles, two types of 3D scaffolds, PTFE/PVA (PP) and PTFE/PVA/GO (PPG), were developed by cross-linking and freeze-drying methods. The physicochemical features of scaffolds were assessed and the interaction of the 3D scaffold types with human adipose mesenchymal stem cells (hADSCs) including attachment, proliferation, and differentiation to osteogenic like cells were investigated. Results: GO nanoparticles were successfully synthesized with no agglomeration. The blending of PTFE as a hydrophobic polymer with PVA polymer and GO nanoparticles (hydrophilic compartments) were successful. Two types of 3D scaffolds had nano topographical structures, good porosities, hydrophilic surfaces, thermal stabilities, good stiffness, as well as supporting the cell attachments, proliferation, and osteogenic differentiation. Notably, GO incorporating scaffolds provided a better milieu for cell behaviors. Conclusion: Novel multiscale porous nanofibrous 3D scaffolds made from PTFE/ PVA polymers with and without GO nanoparticles could be an ideal candidate for bone tissue engineering as a 3D template.
Identification and ranking of important bio-elements in drug-drug interaction by Market Basket Analysis
Authors: Ferdousi Reza , Jamali Ali Akbar , Safdari Reza
Published: April 2020

Introduction:
Drug-drug interactions (DDIs) are the main causes of the adverse drug reactions and the nature of the functional and molecular complexity of drugs behavior in the human body make DDIs hard to prevent and threat. With the aid of new technologies derived from mathematical and computational science, the DDI problems can be addressed with a minimum cost and effort. The Market Basket Analysis (MBA) is known as a powerful method for the identification of co-occurrence of matters for the discovery of patterns and the frequency of the elements involved. Methods: In this research, we used the MBA method to identify important bio-elements in the occurrence of DDIs. For this, we collected all known DDIs from DrugBank. Then, the obtained data were analyzed by MBA method. All drug-enzyme, drug-carrier, drug-transporter and drug-target associations were investigated. The extracted rules were evaluated in terms of the confidence and support to determine the importance of the extracted bio-elements. Results: The analyses of over 45 000 known DDIs revealed over 300 important rules from 22 085 drug interactions that can be used in the identification of DDIs. Further, the cytochrome P450 (CYP) enzyme family was the most frequent shared bio-element. The extracted rules from MBA were applied over 2 000 000 unknown drug pairs (obtained from FDA approved drugs list), which resulted in the identification of over 200 000 potential DDIs. Conclusion: The discovery of the underlying mechanisms behind the DDI phenomena can help predict and prevent the inadvertent occurrence of DDIs. Ranking of the extracted rules based on their association can be a supportive tool to predict the outcome of unknown DDIs.
Placenta mesenchymal stem cells differentiation toward neuronal-like cells on nanofibrous scaffold
Authors: Rahimi-Sherbaf Fatemeh , Nadri Samad , Rahmani Ali , Dabiri Oskoei Atousa
Published: April 2020

Introduction:
Transplantation of stem cells with a nanofibrous scaffold is a promising approach for spinal cord injury therapy. The aim of this work was to differentiate neural-like cells from placenta-derived mesenchymal stem cells (PDMSCs) using suitable induction reagents in three (3D) and two dimensional (2D) culture systems. Methods: After isolation and characterization of PDMSCs, the cells were cultivated on poly-L-lactide acid (PLLA)/poly caprolactone (PCL) nanofibrous scaffold and treated with a neuronal medium for 7 days. Electron microscopy, qPCR, and immunostaining were used to examine the differentiation of PDMSCs (on scaffold and tissue culture polystyrene [TCPS]) and the expression rate of neuronal markers (beta-tubulin, nestin, GFAP, and MAP-2). Results: qPCR analysis showed that beta-tubulin (1.672 fold; P ≤ 0.0001), nestin (11.145 fold; P ≤ 0.0001), and GFAP (80.171; P ≤ 0.0001) gene expressions were higher on scaffolds compared with TCPS. Immunofluorescence analysis showed that nestin and beta-tubulin proteins were recognized in the PDMSCs differentiated on TCPS and scaffold after 7 days in the neuroinductive differentiation medium. Conclusion: Taken together, these results delegated that PDMSCs differentiated on PLLA/PCL scaffolds are more likely to differentiate towards diversity lineages of neural cells. It proposed that PDMSCs have cell subpopulations that have the capability to be differentiated into neurogenic cells.
Modeling of environmental aspects related to reverse osmosis desalination supply chain
Authors: Mehrgan Mohammad Reza , Mahdiraji Hannan Amoozad , Binaee Shahab , Alipour Vali , Razavi Haji Agha Seyyed Hossein
Published: April 2020

Background: This study aimed to model optimization of strategic environmental management decisions in the operation of reverse osmosis desalination, emphasizing the costs required for the environmental protection during the production of freshwater using reverse osmosis technology. Methods: This analytical research was conducted in five cities of Hormozgan province in Iran for 18 months from February 2018 to September 2019. The research includes eight phases of defining the research problem, data collection, preliminary data analysis and decision criteria, mathematical modeling, model validation, information preparation, analysis and finally discussion, conclusions and suggestions. The main environmental issues were the carbon dioxide (CO2 ) release rate due to power demand and rejected brine water (RBW) were entered the mathematical model. Results: The desalination plants of Abu Musa, Bandar Abbas, Qeshm, Sirik, and Hormoz with water production flow rate of 2100, 89 000, 5300, 3300 and 1500 m3 /d can generate 2360.82, 100053.80, 5958.260, 3709.86 and 1686.30 tons/year of CO2 emissions respectively. This output requires 1.35, 57.47, 3.42, 2.13 and 0.97 million USD for controlling the process, respectively. For reduction of the negative effect of RBW 0.75, 22.79, 1.78, 1.15 and 0.55 million USD respectively, is needed. Conclusion: Recommendations for environmental impacts protection of RBW, for desalination capacity up to 50 000 m3 /d, are; (a) for desalination capacity up to 50 000 m3 /d; dilution the RBW using raw water before entering into the sea, (b) for capacity of 50 000-100 000 m3 /d; dispersing RBW in sea using diffuser, and (c) for capacity more than 100 000 m3 /d; hybrid water desalination plants and power plant. Application of power plant cooling water to dilute RBW may reduce cost.
A new magnetic bio-sorbent for arsenate removal from the contaminated water: Characterization, isotherms, and kinetics
Authors: Adlnasab Laleh , Djafarzadeh Nader , Maghsodi Akram
Published: April 2020

Background: Arsenic (AS) is a heavy metal pollutant in water that has been known as one of the most important environmental contaminants due to its serious effects on both human health and the environment. This study was conducted to investigate the efficiency of calcined Co/Fe/Al LDH@Fe3 O4 @ PA as a new magnetic bio-sorbent for AS removal from the polluted water. Methods: At first, magnetic ternary calcined layered double hydroxide (Co/Fe/Al LDH) was synthesized through co-precipitation procedure. The synthesized CLDH was modified with phenylalanine amino acid, named CLDH@Fe3 O4 @PA. Infrared spectroscopy, X-ray diffraction, transmission, and field emission scanning electron microscopy (FESEM) were used to confirm the synthesis of the sorbent. The removal time, pH, and the sorbent dose were studied and optimized as the effective parameters on the As (V) removal. Results: The XRD, FTIR, TEM, SEM, EDS, and VSM techniques confirmed the properties of the synthesized magnetic bio-sorbent. Based on the optimization study, pH=6, the sorbent concentration of 30 mg, and the removal time of 5 minutes were considered as the optimum conditions with about 91% AS removal. The Langmuir isotherm with higher R2 value was matched well with the obtained results, and values obtained for qm and RL were 167 mg g–1 and 0.976 to 0.993, respectively. The kinetics studies were fitted well with the linear pseudo-first-order model with higher R2 at sorption process. Conclusion: The real samples results confirmed the excellent As (V) sorption capacity of the synthesized magnetic bio-sorbent in comparison with other sorbents. Therefore, CLDH@Fe3 O4 @PA sorbent is introduced as a new suitable sorbent for removal of As (V) from the polluted water.
Novel single nucleotide mutations in exon-10 of human coagulationFactor V gene in patients with pulmonary thromboembolism
Authors: Kasala Latheef , Durgaprasad Rajasekhar , Velam Vanajakshamma
Published: April 2020

Introduction: Acute pulmonary thromboembolism (PTE) presents with wide spectrum and has variable prognosis. Factor V Leiden (FVL) is the most common inherited thrombophilia, with a prevalence of 3%-7% in the general US population, approximately 5% in Whites, 2.2% in Hispanics and 1.2% in Blacks. PTE most commonly originates from venous thrombosis. The occurrence of venous thromboembolism is a culmination of environmental and genetic risk factors. The current study was sought to identify the mutations in exon-10 of FV gene in patients with PTE.
 Methods: Sixty cases diagnosed with PTE and 50 healthy controls were enrolled in the present study. Mutation studies in exon-10 of Factor V gene included PCR-DNA sequencing method.
 Results: Of 60 patients, we found two novel transition type point mutations: c.1538 G>A and c.1601 G>A in exon-10 of Factor V which is responsible for the cleavage site for aPC. These point mutations resulted in single amino acid change in protein sequence at p.Arg513Lys and p.Arg534Gln respectively. These mutations prevent efficient inactivation of Factor V and Factor V remains active which facilitates over production of thrombin leading to generation of excess fibrin and excess coagulation which results in deep vein thrombosis and PTE.
 Conclusion: We report two novel point mutations (c.1538 G>A and c.1601 G>A) in exon-10 of Factor V gene in Indian patients with PTE.
Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction
Authors: Khorrami Arash , Ziaee Mojtaba , Rameshrad Maryam , Nakhlband Ailar , Maleki-Dizaji Nasrin , Garjani Alireza
Published: April 2020

Introduction: The present study examined the effects of high cholesterol and high oxidized-cholesterol diets on the myocardial expression of TLR4 and pro-inflammatory cytokine in rats.
 Methods: Male Wistar rats were allocated into 6 groups and fed with a normal diet, cholesterol, and oxidized-cholesterol rich diets with or without isoproterenol-induced myocardial infarction. TLR4 and MyD 88 expression and levels tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were measured in the heart and serum.
 Results: Oxidized cholesterol-fed animals had higher serum levels of oxidized low-density lipoprotein (LDL) (263 ± 13 ng/dL) than the cholesterol-fed animals (98 ± 8 ng/dL; P < 0.001). A high level of oxidized-LDL caused fibrotic cell formation and enhanced neutrophil infiltration in the absence of MI. Both cholesterol and oxidized-cholesterol upregulated TLR4 mRNA expression and increased TNF-α and IL-6 production in the hearts of rats with MI. In rats fed with oxidized-cholesterol the serum and myocardial levels of TNF-α (653 ± 42 pg/mL, 1375 ± 121 pg/100 mg, respectively) were higher than MI group (358±24 pg/mL, P < 0.001 and 885 ± 56 pg/100 mg, P < 0.01). A significant correlation was seen between TLR4 expression and infarct size.
 Conclusion: These findings suggest that cardiac TLR4 is preferentially upregulated by oxidized cholesterol in rats. Oxidized cholesterol may have a critical role in cardiac toxicity in the absence of pathological conditions.
Association between the risks of contrast-induced nephropathy after diagnostic or interventional coronary management and the transradial and transfemoral access approaches
Authors: Firouzi Ata , Alemzadeh-Ansari Mohammad Javad , Mohammadhadi Naser , Peighambari Mohammad Mehdi , Zahedmehr Ali , Mohebbi Bahram , Kiani Reza , Sanati Hamid Reza , Shakerian Farshad , Rashidinejad Alireza , Ghadrdoost Behshid , Asghari Raana , Shokrollahi Yancheshmeh Simin
Published: April 2020

Introduction: The risk of contrast-induced nephropathy (CIN) as a common and important complication of coronary procedures may be influenced by the vascular access site. We compared the risks of CIN in diagnostic or interventional coronary management between patients treated via the transradial access (TRA) and those treated via the transfemoral access (TFA).
 Methods: Patients undergoing invasive coronary catheterization or percutaneous coronary intervention (PCI) were enrolled. We excluded patients with congenital or structural heart disease and those with end-stage renal disease on dialysis. Based on the vascular access site used for invasive coronary catheterization, the patients were divided into 2 study groups: the TFA and the TRA. CIN was defined as an absolute (≥0.5 mg/dL) or relative (>25%) increase in the baseline serum creatinine level within 48 hours following cardiac catheterization or PCI.
 Results: Overall, 410 patients (mean age = 61.3 ± 10.8 years) underwent diagnostic or interventional coronary management: 258 were treated via the TFA approach and 152 via the TRA approach. The patients treated via the TFA had a significantly higher incidence of postprocedural CIN (15.1% vs 6.6%; P = 0.01). The multivariate analysis showed that the TFA was the independent predictor of CIN (OR: 2.37, 95% CI: 1.11 to 5.10, and P = 0.027). Moreover, the BARC (Bleeding Academic Research Consortium) and Mehran scores were the other independent predictors of CIN in our study.
 Conclusion: The risk of CIN was lower with the TRA, and the TFA was the independent predictor of CIN after the diagnostic or interventional coronary management.
Gender-based difference in early mortality among patients with STsegment elevation myocardial infarction: insights from Kermanshah STEMI Registry
Authors: Siabani Soraya , Davidson Patricia M , Babakhani Maryam , Salehi Nahid , Rahmani Yousef , Najafi Farid , Karim Hossein , Soroush Ali , Hamzeh Behrooz , Amiri Mojtaba , Siabani Hossein
Published: April 2020

Introduction: This study aimed to evaluate the in-hospital mortality of patients with ST-segment elevation myocardial infarction (STEMI), according to gender and other likely risk factors.
 Methods: This study reports on data relating to 1,484 consecutive patients with STEMI registered from June 2016 to May 2018 in the Western Iran STEMI Registry. Data were collected using a standardized case report developed by the European Observational Registry Program (EORP). The relationship between in-hospital mortality and potential predicting variables was assessed multivariable logistic regression. Differences between groups in mortality rates were compared using chi-square tests and independent t-tests.
 Results: Out of the 1484 patients, 311(21%) were female. Women were different from men in terms of age (65.8 vs. 59), prevalence of hypertension (HTN) (63.7% vs. 35.4%), diabetes mellitus (DM) (37.7% vs. 16.2%), hypercholesterolemia (36.7% vs. 18.5%) and the history of previous congestive heart failure (CHF) (6.6% vs. 3.0%). Smoking was more prevalent among men (55.9% vs. 13.2%). Although the in-hospital mortality rate was higher in women (11.6% vs. 5.5%), after adjusting for other risk factors, female sex was not an independent predictor for in-hospital mortality. Multivariable analysis identified that age and higher Killip class (≥II) were significantly associated with in-hospital mortality rate.
 Conclusion: In-hospital mortality after STEMI in women was higher than men. However, the role of sex as an independent predictor of mortality disappeared in regression analysis. The gender based difference in in-hospital mortality after STEMI may be related to the poorer cardiovascular disease (CVD) risk factor profile of the women.
Angiographic evaluation of traumatic arterial injuries of the upper limbs: a retrospective study
Authors: Shakeri-Bavil Abolhassan , Zarrintan Sina
Published: April 2020

Introduction: The aim of this study was to evaluate the mechanism and type of upper limb arterial trauma in Iranian population.
 Methods: Fifty-one patients with upper limb trauma were evaluated over a 4-year period with conventional angiography at the Tabriz Imam Hospital, Iran.
 Results: Twenty-four patients (19 men, 5 women with a mean age of 27.5 ± 11.8 years) had arterial injuries. Blunt trauma was more frequent than penetrating trauma (87.5%). The most cause of trauma was traffic accidents and the brachial artery was the most frequently affected artery. In 87.5% cases associated bone injuries were observed.
 Conclusion: Patients with blunt upper limb injuries must be evaluated for vascular integrity timely, especially in traffic accidents because vascular injuries after traffic accidents need to be referred to vascular centers. The results of this article are of potential use and clinical importance because precise diagnosis of vascular insults are essential to restore injured extremities.
Isolated cardiac hydatid cyst presented as myopericarditis: A case report
Authors: Vakilian Farveh , Kamali Akabr , Azari Ali , Poorzand Hoorak , Kamali Amir , Vakili Ahrari Roodi Somayeh
Published: April 2020

Hydatidosis commonly affect the liver and lungs but in rare cases, it can involve heart tissue. A 42-year-old man from urban areas of Khorasan Razavi province, northeastern Iran, was referred to the cardiac clinic with palpitation, and atypical chest pain in 2018. Large pericardial effusion, reduced left ventricle systolic function was found. A cystic-like lesion was also seen in inter-ventricular septum in echocardiography and high-resolution computed tomography (HRCT). Urgent cardiac surgery was done because of echocardiographic evidence of tamponade. Although the serologic analysis was negative for hydatidosis, surgical excision of cyst and the subsequent histopathological findings revealed a hydatid cyst. In endemic areas, hydatidosis should be considered in differential diagnosis of any cystic-like lesions, even if the serological analysis is negative.
Coefficient Estimates of Some Classes of Univalent Functions using Subordination Principle
Authors: Fadipe-Joseph Olubunmi A. , Aina E. A. , Titiloye E. O.
Published: April 2020

In this work, two classes T(b, λ) and V(b, λ) were defined. Coefficient bounds, Fekete-Szegö functional and Hankel determinants for the classes were obtained. The results obtained generalized some earlier ones.
EVALUASI PELAKSANAAN KURIKULUM 2013 DAN KURIKULUM TINGKAT SATUAN PENDIDIKAN (KTSP) PADA PEMBELAJARAN GEOGRAFI DI SMAN KOTA PADANG
Authors: Simponi Maijem , Pratama M Iqbal Liayong
Published: April 2020

Education system has it's own problems.  Indonesia's education also involves the challenge of implementing the new curriculum. The schools are not ready yet to implement the new curriculum, the 2013 curriculum. The 2013 curriculum which emphasizes character development, requires teachers to carry out comprehensive learning and a full assessment of each student's development. This study aims to describe and evaluate the implementation of the 2013 Curriculum and SBC in geography learning at High School in Padang city. This research used descriptive qualitative by using purposive sampling. The sample of this paper are teachers and students who teach and learn geographic subject, principals and vice-principals.  The Data were collected through observation, interviews and documentation.  The results revealed that:  (1) Evaluation of the implementation of KTSP; The planning of learning in SBC emphasizes more on the delivery of material whose learning success is measured through cognitive tests. The implementation of KTSP learning is carried out conventionally, depending on the teacher and creative learning. Teachers' creativity in teaching is the main in creating creative learning so that national education goals are achieved. Assessment of KTSP learning uses reference criteria; that is based on what students understand after participating in the learning process, using a test gauge. Learning success can be seen in the acquisition of student learning outcomes. (2)evaluation of the 2013 curriculum, planning is designed based on instructions from the government and must explore all the potentials and abilities of students and all norms of life. The implementation of 2013 curriculum learning, learning is carried out holistically to achieve overall objectives as well, so that all potential students will be explored listed in the four core competencies by using various assessment instruments, Assessment in  the 2013 curriculum is carried out based on scientific assessments that assess all potentials possessed by participant. Assessment is not only limited to the test instrument, but also through various instruments