bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemodynamic Heterogeneity of Reduced Cardiac Reserve Unmasked by Volumetric Exercise Echocardiography
Authors: Bombardini Tonino , Zagatina Angela , Ciampi Quirino , Arbucci Rosina , Merlo Pablo , Haber Diego , Morrone Doralisa , D'Andrea Antonello , Djordjevic-Dikic Ana , Beleslin Branko , Tesic Milorad , Boskovic Nikola , Giga Vojislav , de Castro e Silva Pretto José , Daros Clarissa , Amor Miguel , Mosto Hugo , Salamè Michael , Monte Ines , Citro Rodolfo , Simova Iana , Samardjieva Martina , Wierzbowska-Drabik Karina , Kasprzak Jaroslaw , Gaibazzi Nicola , Cortigiani Lauro , Scali Maria , Pepi Mauro , Antonini-Canterin Francesco , Torres Marco , Nes Michele , Ostojic Miodrag , Carpeggiani Clara , Kovačević-Preradović Tamara , Lowenstein Jorge , Arruda-Olson Adelaide , Pellikka Patricia , Picano Eugenio ,   on behalf of the Stress Echo 2020 Study Group of the Italian Society of Cardiovascular Imaging
Published: June 2021

Background: Two-dimensional volumetric exercise stress echocardiography (ESE) provides an integrated view of left ventricular (LV) preload reserve through end-diastolic volume (EDV) and LV contractile reserve (LVCR) through end-systolic volume (ESV) changes. Purpose: To assess the dependence of cardiac reserve upon LVCR, EDV, and heart rate (HR) during ESE. Methods: We prospectively performed semi-supine bicycle or treadmill ESE in 1344 patients (age 59.8 ± 11.4 years; ejection fraction = 63 ± 8%) referred for known or suspected coronary artery disease. All patients had negative ESE by wall motion criteria. EDV and ESV were measured by biplane Simpson rule with 2-dimensional echocardiography. Cardiac index reserve was identified by peak-rest value. LVCR was the stress-rest ratio of force (systolic blood pressure by cuff sphygmomanometer/ESV, abnormal values ≤2.0). Preload reserve was defined by an increase in EDV. Cardiac index was calculated as stroke volume index * HR (by EKG). HR reserve (stress/rest ratio) <1.85 identified chronotropic incompetence. Results: Of the 1344 patients, 448 were in the lowest tertile of cardiac index reserve with stress. Of them, 303 (67.6%) achieved HR reserve <1.85; 252 (56.3%) had an abnormal LVCR and 341 (76.1%) a reduction of preload reserve, with 446 patients (99.6%) showing ≥1 abnormality. At binary logistic regression analysis, reduced preload reserve (odds ratio [OR]: 5.610; 95% confidence intervals [CI]: 4.025 to 7.821), chronotropic incompetence (OR: 3.923, 95% CI: 2.915 to 5.279), and abnormal LVCR (OR: 1.579; 95% CI: 1.105 to 2.259) were independently associated with lowest tertile of cardiac index reserve at peak stress. Conclusions: Heart rate assessment and volumetric echocardiography during ESE identify the heterogeneity of hemodynamic phenotypes of impaired chronotropic, preload or LVCR underlying a reduced cardiac reserve.
Systematic Review with Meta-Analyses: Diagnostic Accuracy of FibroMeter Tests in Patients with Non-Alcoholic Fatty Liver Disease
Authors: Van Dijk Anne-Marieke , Vali Yasaman , Mak Anne Linde , Lee Jenny , Tushuizen Maarten E. , Zafarmand Mohammad Hadi , Anstee Quentin M. , Brosnan M. Julia , Nieuwdorp Max , Bossuyt Patrick M. , Holleboom Adriaan G.
Published: June 2021

Early detection of liver fibrosis is crucial to select the correct care path for patients with non-alcoholic fatty liver disease (NAFLD). Here, we systematically review the evidence on the performance of FibroMeter versions in detecting different levels of fibrosis in patients with NAFLD. We searched four databases (Medline, Embase, the Cochrane library, and Web of Science) to find studies that included adults with NAFLD and biopsy-confirmed fibrosis (F1 to F4), compared with any version of FibroMeter. Two independent researchers screened the references, collected the data, and assessed the methodological quality of the included studies. We used a bivariate logit-normal random effects model to produce meta-analyses. From 273 references, 12 studies were eligible for inclusion, encompassing data from 3425 patients. Meta-analyses of the accuracy in detecting advanced fibrosis (F ≥ 3) were conducted for FibroMeter Virus second generation (V2G), NAFLD, and vibration controlled transient elaFS3stography (VCTE). FibroMeter VCTE showed the best diagnostic accuracy in detecting advanced fibrosis (sensitivity: 83.5% (95%CI 0.58–0.94); specificity: 91.1% (95%CI 0.89–0.93)), followed by FibroMeter V2G (sensitivity: 83.1% (95%CI 0.73–0.90); specificity: 84.4% (95%CI 0.62–0.95)) and FibroMeter NAFLD (sensitivity: 71.7% (95%CI 0.63–0.79); specificity: 82.8% (95%CI 0.71–0.91)). No statistically significant differences were found between the different FibroMeter versions. FibroMeter tests showed acceptable sensitivity and specificity in detecting advanced fibrosis in patients with NAFLD, but an urge to conduct head-to-head comparison studies in patients with NAFLD of the different FibroMeter tests remains.
How the Gut Microbiome Links to Menopause and Obesity, with Possible Implications for Endometrial Cancer Development
Authors: Schreurs Malou P. H. , de Vos van Steenwijk Peggy J. , Romano Andrea , Dieleman Sabine , Werner Henrica M. J.
Published: June 2021

Background: Interest is growing in the dynamic role of gut microbiome disturbances in human health and disease. No direct evidence is yet available to link gut microbiome dysbiosis to endometrial cancer. This review aims to understand any association between microbiome dysbiosis and important risk factors of endometrial cancer, high estrogen levels, postmenopause and obesity. Methods: A systematic search was performed with PubMed as primary database. Three separate searches were performed to identify all relevant studies. Results: Fifteen studies were identified as highly relevant and included in the review. Eight articles focused on the relationship with obesity and eight studies focused on the menopausal change or estrogen levels. Due to the heterogeneity in patient populations and outcome measures, no meta-analysis could be performed. Both the menopausal change and obesity were noted to enhance dysbiosis by reducing microbiome diversity and increasing the Firmicutes to Bacteroidetes ratio. Both also incurred estrobolome changes, leading to increased systemic estrogen levels, especially after menopause. Furthermore, microbiome dysbiosis was reported to be related to systemic inflammation through toll-like receptor signaling deficiencies and overexpression of pro-inflammatory cytokines. Conclusions: This review highlights that the female gut microbiome is intrinsically linked to estrogen levels, menopausal state and systemic inflammation, which indicates gut microbiome dysbiosis as a potential hallmark for risk stratification for endometrial cancer. Studies are needed to further define the role the gut microbiome plays in women at risk for endometrial cancer.
Fundamentals, Diagnostic Capabilities, and Perspective of Narrow Band Imaging for Early Gastric Cancer
Authors: Kurumi Hiroki , Nonaka Kouichi , Ikebuchi Yuichiro , Yoshida Akira , Kawaguchi Koichiro , Yashima Kazuo , Isomoto Hajime
Published: June 2021

The development of image-enhanced endoscopy has dramatically improved the qualitative and quantitative diagnosis of gastrointestinal tumors. In particular, narrow band imaging (NBI) has been widely accepted by endoscopists around the world in their daily practice. In 2009, Yao et al. proposed vessel plus surface (VS) classification, a diagnostic algorithm for early gastric cancer using magnifying endoscopy with NBI (ME-NBI), and in 2016, Muto et al. proposed a magnifying endoscopy simple diagnostic algorithm for early gastric cancer (MESDA-G) based on VS classification. In addition, the usefulness of ME-NBI in the differential diagnosis of gastric cancer from gastritis, diagnosis of lesion extent, inference of histopathological type, and diagnosis of depth has also been investigated. In this paper, we narrative review the basic principles, current status, and future prospects of NBI.
COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
Authors: Lisco Giuseppe , De Tullio Anna , Stragapede Assunta , Solimando Antonio Giovanni , Albanese Federica , Capobianco Martina , Giagulli Vito Angelo , Guastamacchia Edoardo , De Pergola Giovanni , Vacca Angelo , Racanelli Vito , Triggiani Vincenzo
Published: June 2021

Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation.
Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review
Authors: Sanchez-Diaz Manuel , Quiñones-Vico Maria I. , Sanabria de la Torre Raquel , Montero-Vílchez Trinidad , Sierra-Sánchez Alvaro , Molina-Leyva Alejandro , Arias-Santiago Salvador
Published: June 2021

Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this review is to describe how MSCs are distributed after injection, using different administration routes in animal models and humans. A literature search was performed in order to consider how MSCs distribute after intravenous, intraarterial, intramuscular, intraarticular and intralesional injection into both animal models and humans. Studies addressing the biodistribution of MSCs in “in vivo” animal models and humans were included. After the search, 109 articles were included in the review. Intravenous administration of MSCs is widely used; it leads to an initial accumulation of cells in the lungs with later redistribution to the liver, spleen and kidneys. Intraarterial infusion bypasses the lungs, so MSCs distribute widely throughout the rest of the body. Intramuscular, intraarticular and intradermal administration lack systemic biodistribution. Injection into various specific organs is also described. Biodistribution of MSCs in animal models and humans appears to be similar and depends on the route of administration. More studies with standardized protocols of MSC administration could be useful in order to make results homogeneous and more comparable.
Overexpression of p75NTR in Human Seminoma: A New Biomarker?
Authors: Perri Anna , Rago Vittoria , Malivindi Rocco , Maltese Lorenza , Lofaro Danilo , Greco Emanuela Alessandra , Tucci Luigi , Bonofiglio Renzo , Vergine Margherita , La Vignera Sandro , Chiefari Eusebio , Brunetti Antonio , Aversa Antonio
Published: June 2021

Several studies have demonstrated that the p75NTR low-affinity receptor of Nerve Growth Factor (NGF), is produced in abnormally large amounts in several human cancer types. However, the role of p75NTR varies substantially depending on cell context, so that a dual role of this receptor protein in tumor cell survival and invasion, as well as cell death, has been supported in recent studies. Herein we explored for the first time the expression of p75NTR in human specimens (nr = 40) from testicular germ cell tumors (TGCTs), mostly seminomas. Nuclear overexpression of p75NTR was detected by immunohistochemistry in seminoma tissue as compared to normal tissue, whereas neither NGF nor its high-affinity TrkA receptor was detected. An increased nuclear staining of phospho-JNK, belonging to the p75NTR signaling pathway and its pro-apoptotic target gene, p53, was concomitantly observed. Interestingly, our analysis revealed that decreased expression frequency of p75NTR, p-JNK and p53 was related to staging progression, thus suggesting that p75NTR may represent a specific marker for seminoma and staging in TGCTs.
Recent Advances in Brazing Fillers for Joining of Dissimilar Materials
Authors: Ahn Byungmin
Published: June 2021

Brazing fillers for joining applications are essential for manufacturing and designing advanced materials. Several types of brazing fillers have been developed in recent decades to join similar or different engineering materials. Important parts of automotive and aircraft components, including steel, are often joined by brazing. In addition, ceramic components in microwave devices and circuits have been joined with a high level of integration in microelectronic devices. Similarly, in the medical field, metallic implants have been brazed to ceramic dental crowns. These advances have made human life more convenient. However, in brazing, there are certain issues with intermetallic compound (IMC) formation and residual stresses in joints at high temperatures. Nanoparticle-reinforced fillers have been proposed to control IMCs, but there are other dispersion and particle segregation issues at the joints. In this study, various types of brazing fillers, joint fabrication processes, and brazing technologies developed in recent decades are reviewed. Furthermore, new developments in brazing materials and their specific applications are presented. Finally, the emerging areas in brazing, including the recent entropy-modified brazing fillers for various structural and technological fields, are discussed.
Complex pharmaco-ozone therapy in the prevention of placental insufficiency in high-risk pregnancy
Authors: Tsallagova L. V. , Maisuradze L. V. , Sagkaeva S. V. , Tsidaeva T. I.
Published: June 2021

Summary. Purpose of research. Development of a method for prevention of placental insuffi ciency (PN) in high-risk pregnancy in women of the Republic of North Ossetia-Alania (RSO-A) with the complex use of antihypoxant limontar and ozone therapy (OT).
Material and methods. Observations were made of 75 pregnant residents of RSO-A with diagnosed PN, whose average age was 32,6 ± 8,14 years. Using a simple randomization method, 3 groups were formed: in the main group (OG), patients received
prevention of PN by using OT and antihypoxant limontar; in the comparison group (GS), only limontar; in the control group (KG), pregnant women did not receive prevention of PN. All patients observed before and after PN prevention were examined for placental lactogen and estriol, ultrasound of the fetoplacental complex (FPC), Doppler examination of the uterine blood fl ow and ultrasound examination of the placenta structure, and
morphological examination of the placenta.
Results. Based on identifi ed pathogenetic mechanisms of the disorders in the system “mother — placenta — fetus” are defined by a high clinical effi cacy of combined pharmaco-ozone therapy (CT) in the prevention of PN in pregnant women at risk, which was manifested by the lack of progression of PN, whereas in GS, where patients received only pharmacotherapy with limontar, progression was noted in 31,8 % of cases, in KG, where there was no prevention, is 56 %.
Conclusion. In the present study, the positive effect of OT and antihypoxant limontar on the processes of microcirculation, metabolism, and adaptation of the body, which provides a signifi cant reduction in the frequency of pregnancy complications,
increasing the adaptive capabilities of the fetus and improving perinatal outcomes.
Features of the use of stable platforms with biological feedback in various socially significant diseases
Authors: Kotenko K. V. , Korchazhkina N. B. , Mikhailova A. A. , Illarionov V. E. , Epifanov V. A.
Published: June 2021

The article presents research data on the features of the use of stable platforms with biological feedback in various socially significant diseases.
Dry carbon dioxide baths in complex spa treatment of children and adolescents with diseases of the cardiovascular system
Authors: Kaisinova A. S. , Kulakovskaya T. V. , Danielyan L. G. , Cheparina G. P. , Chalaya E. N.
Published: June 2021

These guidelines provide a scientifi c justifi cation for the use of dry carbon dioxide baths in the General complex of Spa treatment of children and adolescents with diseases of the cardiovascular system.
The guidelines are intended for doctors of medical rehabilitation, pediatricians, therapists, cardiologists, physiotherapists of specialized medical and preventive institutions, rehabilitation departments and centers, sanatoriums, and dispensaries.
Atopic dermatitis: evaluation of the influence of physiotherapy on the barrier function of the skin and the severity of the course of dermatosis in children
Authors: Koroleva T. V. , Ivanova I. I. , Filatova E. V.
Published: June 2021

The article presents data on the dynamics of indicators reflecting the barrier function of the skin: pH-metry, TEWA-metry and corneometry, under the infl uence of physiological factors. It was shown that under the influence of polarized light, laser radiation and hydrotherapy, in combination with drug treatment, the maximum decrease in the Scorad index is determined by 4,5 times. Moreover, each of the applied factors had a positive effect.
Features of the course of regeneration processes in myometry under the influence of general magnetotherapy and selective pulsed electrical stimulation with low frequency currents in patients after myomectomy
Authors: Lyadov K. V. , Koneva E. S. , Muravlev A. I.
Published: June 2021

The aim of the study was to identify the features of the course of repair processes in myometry under the influence of selective pulsed electrostimulation as a monomethod and in combination with system-wide magnetotherapy according to ultrasound data in patients after myomectomy. The study included 105 patients aged 28 to 59 years after myomectomy. All patients were divided into 3 groups of 35 people: the control group did not receive physical therapy. Patients of the main group with 2 days after surgery was carried out, the total magnetic therapy with the duration of 15 minutes, at the rate of 10
daily procedures in combination with the selective pulsed electrical stimulation currents of low frequency with a duration of 25 minutes, at the rate of 10 daily procedures; patients in the comparison group from the 2nd day after surgery was conducted
by selective pulsed electrical stimulation currents of low frequency, duration 25 minutes, at the rate of 10 daily procedures. In the study it was found that the most pronounced stimulation of regenerative processes and proper formation of postoperative
scar in patients in the early postoperative period after myomectomy was noted under the influence of complex application of General magnetic therapy in combination with selective pulsed electrical stimulation currents of low frequencies through
tristimulous and regenerative eff ects are somewhat less significant results were obtained when monophospate selective pulsed electrical stimulation currents of low frequency. The obtained results indicate the prospects of including the developed
complex in the programs of early rehabilitation of patients after myomectomy to improve the flow of regeneration processes in the myometrium and prevent the development of suture failure.
Questions of neurorehabilitation. Innovative technologies of neurorehabilitation
Authors: Sidyakina I. V. , Voronova M. V. , Ivanov V. V. , Snopkov P. S. , Epifanov V. A.
Published: June 2021

The report is devoted to modern methods of neurorehabilitation, which are actively being introduced into the clinical practice of rehabilitation treatment centers. The technologies used at all stages of rehabilitation are described, starting from the intensive care unit, ending with remote methods used after the patient is discharged from the hospital. We consider robotic technologies, mechanotherapy with biofeedback, non-invasive stimulation techniques, virtual reality technology. Data on the effectiveness of rehabilitation treatment procedures from the perspective of evidence-based medicine are presented.
Questions of neurorehabilitation. Modern strategies of neurorehabilitation
Authors: Shapovalenko T. V. , Sidyakina I. V. , Voronova M. V. , Ivanov V. V. , Illarionov V. E.
Published: June 2021

The publication is devoted to modern strategies for neurorehabilitation of patients after stroke. Special attention is paid to the issues of individualization of rehabilitation programs based on the initial neurological defi cit and neurophysiological monitoring data. Modern scales of functional state assessment are described, and the diagnostic value of traditional and innovative methods of studying the state of central nervous system structures is compared: registration of somatosensory evoked potentials, transcranial magnetic stimulation, and functional magnetic resonance imaging. The issues of diff erentiation of the level of consequences of the disease, stages of rehabilitation treatment, eff ectiveness and safety of rehabilitation procedures are discussed.
Effectiveness of rehabilitation of patients with cerebrovascular insufficiency using the biofeedback method
Authors: Rylskiy A. V. , Oranskaya A. N. , Gurevich K. G.
Published: June 2021

Objective: To study the effectiveness of the biological feedback (BOS) method in the rehabilitation of patients with cerebral circulation disorders. Materials and methods: 555 patients with chronic cerebral ischemia were examined. All the patients were diagnosed with problems with movement coordination in vertical position. If necessary, the patients received standard conservative therapy. In addition to it, a method for increasing physical activity based on the BOS method was used. A stabilometric
examination was carried out on Trust-M equipment. Patient 10m walking time was evaluated. The patients’ quality of life was assessed on a visual analogue scale (VAS). Body mass index (BMI) was calculated based on the measurement of patient height
and weight. Results: Before the start of the treatment, there is a tendency of a decrease in the average speed of movement in BOS with age. The average speed of movement in women is lower than that in men. With age, the maximum horizontal speed of
movement also decreases. After the treatment, the speed of movement in men decreased in all age groups, and in women, the speed increased in groups older than 60 years. In all age groups, women had a larger increase in the rate of movement. Before the treatment, men spent less time than women on performing a walking test of 10 m. After the treatment, the test time decreases only in the group of men of 61 years and older, and in women — in the group of 51 years and older. The original quality of life of
men, measured by the VAS scale, is higher than that of women. These diff erences become unreliable starting from the third BOS session. As a result of the treatment, the energy spent on maintaining the vertical position of the body in the group of persons up
to 50 years is reduced. The correlations of mean force between the BMI and the energy spent on maintaining the vertical body position and upright posture retention were obtained. In persons under 50 years of age, the correlation coeffi cient in men is
signifi cantly greater than in women. The correlation coeffi cient tends to decrease with age. Conclusion: It has been demonstrated that BOS therapy can have a positive eff ect on patients with cerebrovascular diseases (the increased speed of movement and
reduced energy consumption on keeping the body in an upright position). The intensity of the eff ect depends on gender and age.
Theoretical justification of mineral water inhalations in the complex therapy of common diseases under the adverse effects of natural factors of the Arctic zone of the Russian Federation
Authors: Frolkov V. K. , Nagornev S. N. , Korchazhkina N. B.
Published: June 2021

Unfavorable natural factors in the Arctic can be the reason for the formation of various somatic diseases or their exacerbations. Respiratory organs are one of the primary systems that perceive the pathogenic potential of these factors. Since the cells of the APUD system, producing hormones and other biologically active substances, are concentrated in the upper respiratory tract, one can assume their participation in the negative effects of the natural conditions of the Arctic north. It was previously demonstrated that a change in the activity of the APUD-system of the digestive tract can also provoke various diseases and the therapeutic efficacy of drinking mineral waters is due to their stimulating effect on this functional system. It was found that the inhalation of mineral water, even with a single exposure, has a significant polymodal effect on the secretion of hormones and the regulation of metabolic reactions: first, the production of gastrin, glucagon, vasoactive intestinal polypeptide and the content of free fatty acids in the blood are activated. Then, there is an increase in insulin secretion and serotonin levels in the blood against the background of inhibition of aldosterone secretion. With the course use of mineral water inhalations, it was found that its therapeutic effect in patients with duodenal ulcer disease, as well as in patients with metabolic syndrome, is associated with changes in the hormonal regulation of carbohydrate and lipid metabolism, which justifies the possibility of using the method of mineral water inhalations for the treatment and prevention of the diseases caused by the negative impact of natural factors in the Arctic.
Normoxic barotherapy in medical rehabilitation of patients after the novel coronavirus infection
Authors: Kaisinova A. S. , Semukhin A. N. , Abramtsova A. V. , Efimenko N. V. , Velikanov D. I. , Simonova T. M.
Published: June 2021

The purpose of the study is to develop a medical rehabilitation program for the patients who have come through a new coronavirus infection in the resort of Pyatigorsk. Material and methods. In the conditions of the health center named after S.M. Kirov in Pyatigorsk, a branch of FSBI NCFSCC FMBA of Russia, there have been observed 52 patients who had the new coronavirus infection COVID-19 of moderate severity, at the age from 18 up to 65 years old. Two groups have been formed by simple randomization: in the main group, the patients received normoxic barotherapy against the background of traditional spa therapy for pulmonary patients; in the control group, the patients had only conventional therapy. Results. The inclusion of normoxic barotherapy in the complex of medical rehabilitation of patients who came through the novel coronavirus infection contributed to the increase of tolerance to exercise and improved blood oxygen saturation in 92,9 % of cases, restoration of impaired functions of bronchopulmonary apparatus in 89,3 % and physical and mental health in 85.7 % of cases, which was significantly higher in comparison to similar indicators in the control group. Conclusion. Medical rehabilitation of patients after the new coronavirus infection in the resort is justified and advisable.
Dynamics of clinical and morphological parameters in patients with peptic ulcer in the combined laser therapy
Authors: Baybulatov A. G. , Gilmutdinov A. R. , Kunafin A. F. , Gilmutdinov B. R. , Usmanov F. F.
Published: June 2021

The eff ectiveness of the use of a therapeutic complex based on the combined eff ects of intragastric low-intensity and transcutaneous infrared laser therapy in the antiulcer drug therapy of 60 patients with gastric ulcer and duodenal ulcer was studied. In all
30 patients of the main group, after a course of combined laser exposure, the regression of the morphological picture of the activity of the infl ammatory process with epithelialization of the ulcer defect and positive dynamics of the clinical manifestations of the disease within 10 days of treatment was noted. Meanwhile, in the patients of the control group (n = 30), the positive dynamics of similar parameters in the same period was achieved in 70 % of patients against the background of basic drug therapy.
Complex medical rehabilitation of adolescents with dentoalveolar pathology in orthodontic treatment
Authors: Kokareva A. V. , Zelenskiy V. A. , Gaidamaka I. I. , Pachin S. A. , Gusov R. M. , Stolyarov A. A.
Published: June 2021

The purpose of the study is to increase the effectiveness of medical rehabilitation of adolescents with dentoalveolar pathology in orthodontic treatment based on the inclusion of florentine waters, therapeutic physical exercise according to the craniovertebral method, and osteopathic craniosacral therapy in rehabilitation regimens. Material and methods. There have been observed 106 adolescents with dentoalveolar pathology on orthodontic treatment. They were distributed into 3 groups by simple randomization: in the main group 2, the patients received gum irrigation with fir extract florentine water, physical therapy exercises (PTE) according to the craniovertebral method and osteopathic craniosacral therapy in combination with the standard therapy; in the main group 1, the patients were prescribed gum irrigation with fir extract florentine water and PTE according to the craniovertebral method in combination with standard therapy; in the group of comparison, the patients had only irrigation of the gums with fir extract florentine water in combination with standard therapy. Results. In the main group 2, 83,1 % of cases noted levelling of clinical manifestations 6 months later, and 97.9 % — 18–20 months later, while the patients who received irrigation with fir extract florentine water (FW) in combination with standard therapy and PTE according to the craniovertebral method had an improvement in 63,5 % and 85.0 % of cases; when using only irrigations with fir extract FW against the background of standard therapy there was an improvement in 49.4 % and 78.1 % of cases; the reduction of the total number of functional disorders and stabilization of the statokinetic system within 6 months were improved by 1,81 (p < 0.01), and after 18–20 months — 2,61 (p < 0,01) times, while using irrigations with fir extract FW against the background of standard therapy and PTE according to the craniovertebral method, the improvement was by 1,38 (p < 0,01) and 1,69 (p < 0,01) times; when using only irrigations with fir extract FW against the background of standard therapy — by 1,27 (p < 0,05) and 1,73 (p < 0,01) times, respectively, which, with a high degree of reliability, has correlated with the improved dental, physical, and mental health. Conclusion. The developed technology of medical rehabilitation of adolescents using florentine waters, therapeutic physical exercises according to the craniovertebral technique and osteopathic craniosacral therapy is viable and pathogenetically justified.
Cooperation of the UN specialized agencies with the countries of the world (experience of the ILO in Uzbekistan)
Authors: Sultanova E.
Published: June 2021

Based on the study of international experience in the development of the fundamental principles of the International Labor Organization, the specifi cs of its activities, the signifi cance for national states, in particular, Uzbekistan, are revealed. The article focuses in detail on the adopted legal norms aimed at ensuring full employment and improving the standard of living, creating jobs that provide the necessary protection of life and health, the well-being of mothers and children, equal opportunities for men and women to obtain the desired housing, opportunities for education, intellectual development, and career growth.
STYLISTIC STAGES AND SPATIAL PLANNING SOLUTIONS IN THE ARCHITECTURE OF THE ENSEMBLE OF BUILDINGS AND STRUCTURES OF THE TOWN OF KORENNAYA PUSTYN IN THE KURSK REGION 2ND HALF OF THE XVIII – 1ST HALF OF THE XIX CENTURIES
Authors:   Research Institute of Theory and History of Architecture and Urban Planning (NIITIAG) Branch of the Federal State Budgetary Institution ", KHOLODOVA E.V. ,   TsNIIP of the Ministry of Construction of Russia"
Published: June 2021

The study is based on little-known factual material: a comprehensive analysis of documentary and printed sources of central and regional archives, museums and libraries; family domestic and foreign archives; a full-scale survey of the preserved fragments of the Korennaya Pustyn settlement. The scientific novelty of the research is connected with the author's expeditions and surveys of the development complex of the village of Korennaya Pustyn (monastery, fair, village) (measurements, photo-fixation, full-scale sketches), archival and printed sources that resurrect images of lost noble and merchant estates of dachas are identified, and a general analysis of the given topic is carried out. An important result of the study is the disclosure of the phenomenon of country estate construction of the Kursk province settlement as part of the monastery and fair complex of the town of Korennaya Pustyn in the 2nd half of the XVIII – 1st half of the XIX centuries.. The paper considers the features of stylistic stages and spatial planning solutions in the architecture of the ensemble of buildings and structures of a unique settlement. The research was carried out at the expense of the State Program of the Russian Federation "Development of Science and Technology" within the framework of the Plan of Basic Scientific Research of the Ministry of Construction of the Russian Federation and the RAASN.
RENOVATION OF THE COASTAL AREAS ON THE EXAMPLE CENTRAL EMBANKMENT OF THE CITY OF VOLGOGRAD
Authors:   Voronezh state technical University, GUREVA E.I. , GRIBTSOVA A.A. ,   Voronezh state technical University
Published: June 2021

The objectives of the study were the questions of the prerequisites for the renovation of the coastal territory of Volgograd for the formation of sustainable development of the territories of the Volgograd agglomeration. The article presents the results of an urban planning analysis: functional zoning of the embankment territory; a scheme for the reorganization of the territory within the boundaries of the concept development; a scheme for the classification of green areas and retrospective material. The article substantiates the relevance of the development of urban recreational spaces, coastal areas, transformation and modernization of existing buildings in the context of solving the problems of urban development. The requirements for evaluation for each characteristic indicator that affects the transformation of the existing image of Volgograd to increase the tourist potential are given. It is established that the planning and architectural and spatial solutions of the Volgograd embankment are pedestrian-transport – two-tiered: the upper and lower tiers have different functional purposes.
INFLUENCE OF INCLINED STIFFENERS IN I-BEAM CONNECTIONS ON BIMOMENT TRANSFERRING
Authors:   Bryansk State Engineering Technological University, SERPIK I.N. , SHKOLYARENKO R.O. ,   Bryansk State Engineering Technological University
Published: June 2021

Shear-free theory of V.Z. Vlasov remains one of the most reasonable approaches to calculating thin-walled bars taking into account constrained torsion. At the same time, the use of this theory for the analysis of deformations of frame structures still requires research in terms of the conditions for transferring forces in bar connections. As noted in some scientific papers, the balance of bimoments can be significantly broken at the joints of thin-walled bars of an open profile in some designs. This paper deals with this phenomenon for steel I-beam profiles, associated with the presence of inclined stiffeners in joint units. Using shell finite element models, the influence of inclined stiffeners on the appearance of bimoment jumps at the pairwise connection of bars is shown. A dependence is derived that makes it possible to take into account the stiffness of the inclined edge in the bar models from the point of view of the restraint of cross-section warping. On the basis of numerical experiments, it was determined that the introduction of such stiffness into the bar finite element schemes of frame structures allows to reflect the condition of bars interaction in the transferring of bimoments with a sufficiently high accuracy for engineering practice.
VERIFICATION OF THE METHOD OF APPLICATION OF THE REDUCTION COEFFICIENT IN THE CALCULATION OF MONOLITHIC REINFORCED CONCRETE SYSTEMS TO RESIST PROGRESSIVE COLLAPSE
Authors:   Moscow State University of Civil Engineering, MITROVIC B.
Published: June 2021

The paper presents a method of using the reduction factor to ensure the stability of monolithic reinforced concrete bearing structures to progressive collapse. Within the framework of the verification study, the correctness and validity of the developed method for the computational analysis of monolithic reinforced concrete bearing systems of buildings and structures to resist progressive collapse were proved. The reduction factor (K1) obtained and justified in the framework of the research performed is the most important deformation characteristic of the special limiting state of monolithic reinforced concrete bearing systems of buildings and structures for an emergency design situation associated with the failure of a local structural element.
PROGRESSIVE COLLAPSE RESISTANCE OF FACILITIES EXPERIENCED TO LOCALIZED STRUCTURAL DAMAGE - AN ANALYTICAL REVIEW
Authors:   National Research Moscow State University of Civil Engineering, FEDOROVA N.V. , SAVIN S.YU. ,   National Research Moscow State University of Civil Engineering
Published: June 2021

During the entire life cycle, the facilities are experienced to force and environmental actions of various nature and intensity. In some cases, such influences can lead to a loss of the bearing capacity of the structural elements of a building, which in turn can lead to a disproportionate failure of the entire structural system. Such phenomenon was called progressive collapse. Major accidents at facilities, such as the collapse of a section of the Ronan Point high-rise residential building (London, 1968), the Sampoong department store (Seoul, 1995), the Transvaal Park pavement (Moscow, 2004), the World Trade Center (New York, 2011) and others, clearly demonstrated the urgency of this problem. In this regard, the regulatory documents of the USA, Great Britain, EU, China, Australia, Russia and other countries established requirements for the need to calculate structural systems of buildings for resist to progressive collapse after sudden localized structural damage. However, the steady increase in the number of new publications on the problem of progressive collapse observed in the world scientific literature indicates that the results of such studies do not yet provide exhaustive answers to all questions related to this phenomenon. In this regard, the proposed review article is aimed at systematizing, generalizing and analyzing new research results on resistance to progressive collapse of facilities, identifying new trends and proposing new research directions and tasks to improve the level of structural safety of design solutions for buildings and structures. In order to achieve this goal, the following aspects were considered: the nature of the impacts leading to progressive collapse; features of modeling the progressive collapse of structural systems of buildings and structures; mechanisms of resistance to progressive collapse and criteria for evaluation of a progressive collapse resistance. Particular attention in the scientific review is paid to the analysis of works related to a new direction of research in the area under consideration, associated with the assessment of the bearing capacity of eccentrically compressed elements of structural systems, the effect on their resistance to progressive collapse of the parameters of the loading mode, degradation of material properties and the topology of the structural system. The significance of the proposed scientific review is that, along with the well-known and new results presented in the English-language scientific literature, it summarizes and analyzes the original approaches, methods and research results published in Russian-language scientific publications, primarily included in the RSCI Web of Science.
Violencia: Una perspectiva internacional
Authors: Fuguet Smith Antonio
Published: June 2021

Se estudia la violencia desde una perspectiva social y educacional, especialmente en países de América del Sur, analizados desde las investigaciones internacionales, con enfoque de Educación Comparada. Lo internacional responde a las características de la globalización que permite observar rasgos comunes y peculiaridades. Así, se resalta la manifestación del problema y las preocupaciones, esfuerzos y contribuciones de investigadores a fin de crear estructuras conceptuales propias del problema. Se han tipificado energizantes para una reflexión, concebidos como motores de acción ante el reto que representa la educación hoy. Funcionan como conectores para entender el problema de la violencia y su impacto. La reflexión se realiza desde una búsqueda hermenéutica integrada por tres fuentes: las referidas a los motores, las que abordan el tema de la violencia y la inspiración del autor como sujeto que interactúa con su experiencia y creación con las fuentes, intersubjetivamente. Se organiza este artículo en tres partes: aspectos procedimentales, la derivación de las categorías de análisis y, la instancia de reflexión.
La interacción Universidad - Sociedad. Un nuevo concepto en la Educación Superior
Authors: Heredia Chumacero Miguel Ángel
Published: June 2021

El artículo hace parte del trabajo de investigación denominado “Modelo Educativo basado en la interacción social universitaria para contribuir a la interacción universidad sociedad desde la materia de Proyectos en la Carrera de Economía de la U.A.T.F.”, y tiene como propósito revelar la importancia de la interacción de la universidad con la sociedad, para formar profesionales según las exigencias y necesidades de la población, desde el enfoque histórico cultural. La estrategia metodológica del artículo, se apoyó en el primer capítulo de la tesis doctoral citada, buscando, por tanto, el desarrollo de tareas asociadas a la temática objeto de análisis, tales como: 1. Valorar la fundamentación epistemológica sobre la relación Universidad-Sociedad; 2. Valorar la formación profesional en el marco de la relación Universidad-Sociedad; y, 3. Caracterizar la formación profesional. Entre los métodos teóricos utilizados, se tienen: el método histórico-lógico, el método de análisis y síntesis; la modelación, el enfoque sistémico-estructural-funcional, y el ascenso de lo abstracto a lo concreto. El alcance estará dado mediante la interacción universidad sociedad en la Carrera de Economía.
Compendio documental para el curso Pensamiento Sociopolítico de Simón Bolívar. Un aporte para el estudio de las ideas bolivarianas
Authors: Hernández Eliécer
Published: June 2021

La finalidad del presente trabajo fue diseñar un compendio documental con el fin de brindar una herramienta para el abordaje del curso Pensamiento Sociopolítico de Simón Bolívar de la especialidad de Geografía e Historia del Instituto Pedagógico de Miranda “José Manuel Siso Martínez” de la UPEL. El estudio fue concebido con un diseño bibliográfico de tipo proyecto especial. El resultado de la investigación, materializado en la elaboración del material, permitió integrar los contenidos conceptuales, procedimentales y actitudinales con la finalidad de que los estudiantes cumplan con las actividades y por ende el logro de los objetivos. En fin, este material constituye un aporte novedoso y una herramienta científica para el estudio de la historia y, en especial, de las ideas bolivarianas de Simón Bolívar.
Conocimientos sobre la competencia ortotónica desarrollados por estudiantes de Educación Básica
Authors: Córdoba Anadelis
Published: June 2021

La investigación planteó diagnosticar cuáles fueron los conocimientos sobre competencia ortotónica que han desarrollado los estudiantes de Educación Básica. La metodología se basó en un enfoque mixto, bajo la modalidad de investigación de campo, de carácter descriptivo e interpretativo. Las técnicas usadas fueron la observación participante y la entrevista, los instrumentos el guión de entrevista y la prueba escrita. Los sujetos de estudios fueron 26 estudiantes de sexto grado de la Unidad Educativa Nacional Sorocaima. Los resultados evidenciaron que la mayoría de los estudiantes manifestaron no entender ni conocer la información concerniente a la acentuación de palabras; por lo que pudiera inferirse que no han recibido enseñanza sobre ello o en todo caso, si la hubo no se logró un aprendizaje significativo, razón por la que se diseñaron estrategias innovadoras que permitan desarrollar y afianzar la competencia ortotónica, elemento clave para el manejo adecuado de la lengua escrita.
La indagación científica promovida en el aula de ciencias naturales: estudio de caso en educación básica y media
Authors: Mora-Cortes Yasna , Siso-Pavón Zenahir
Published: June 2021

Este estudio se planteó explorar la indagación científica que se promueve en el aula de ciencias cuando los profesores emplean este enfoque didáctico. La investigación fue de tipo cualitativo- interpretativo con diseño de estudio de casos. La muestra estuvo conformada por tres profesores de ciencias cuyas prácticas docentes presentan una aproximación al enfoque indagatorio. El estudio aporta información sobre el discurso de los profesores analizado a partir de entrevistas semiestructuradas, observaciones de clases y el análisis de las planificaciones de aula. Para ello se realizó la codificación, reducción y triangulación de datos. Como hallazgos principales se encontró que los profesores implementan procesos indagatorios en el aula de acuerdo con las concepciones individuales y con el significado que les otorgan a la indagación, considerándola como un modelo de enseñanza de las ciencias que permite identificar una situación problemática, desarrollar conocimiento científico escolar transferible, desarrollar habilidades y actitudes propias del quehacer científico.
Conociendo la ansiedad matemática. El rol del docente
Authors: Cordero Arteaga Jully Catherine
Published: June 2021

El aprendizaje de las matemáticas no resulta agradable para muchas personas. Se sienten incómodas, desmotivadas, preocupadas e incluso angustiadas ante situaciones que le exigen análisis lógicos y numéricos, influyendo significativamente en el desarrollo educativo del alumno. Esta condición configura la ansiedad matemática. Ante ello, enmarcado en el proceso de enseñanza y aprendizaje de las matemáticas, al docente le corresponde asumir un rol proactivo que favorezca la superación de la dificultad evidenciada, siempre acompañados del estudiante y la familia que constituyen entes insustituibles. Esta reflexión tiene como objetivo brindar la información fundamental para que el profesorado comprenda la ansiedad matemática, reconozca sus causas y consecuencias, adquiera la capacidad para identificarla y adopte y construya diversas estrategias educativas para afrontar con éxito la ansiedad matemática en el aula de clases.