bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel metabarcoding diagnostic tool to explore protozoan haemoparasite diversity in mammals: a proof-of-concept study using canines from the tropics
Authors: Huggins Lucas G. , Koehler Anson V. , Ng-Nguyen Dinh , Wilcox Stephen , Schunack Bettina , Inpankaew Tawin , Traub Rebecca J.
Published: September 2019

Haemoparasites are responsible for some of the most prevalent and debilitating canine illnesses across the globe, whilst also posing a significant zoonotic risk to humankind. Nowhere are the effects of such parasites more pronounced than in developing countries in the tropics where the abundance and diversity of ectoparasites that transmit these pathogens reaches its zenith. Here we describe the use of a novel next-generation sequencing (NGS) metabarcoding based approach to screen for a range of blood-borne apicomplexan and kinetoplastid parasites from populations of temple dogs in Bangkok, Thailand. Our methodology elucidated high rates of Hepatozoon canis and Babesia vogeli infection, whilst also being able to characterise co-infections. In addition, our approach was confirmed to be more sensitive than conventional endpoint PCR diagnostic methods. Two kinetoplastid infections were also detected, including one by Trypanosoma evansi, a pathogen that is rarely screened for in dogs and another by Parabodo caudatus, a poorly documented organism that has been previously reported inhabiting the urinary tract of a dog with haematuria. Such results demonstrate the power of NGS methodologies to unearth rare and unusual pathogens, especially in regions of the world where limited information on canine vector-borne haemoparasites exist.
Cochlear Glucocorticoid Receptor and Serum Corticosterone Expression in a Rodent Model of Noise-induced Hearing Loss: Comparison of Timing of Dexamethasone Administration
Authors: Lee Seung-Hun , Lyu Ah-Ra , Shin Sun-Ae , Jeong Seong-Hun , Lee Sun-A , Park Min Jung , Park Yong-Ho
Published: September 2019

Glucocorticoid (GC) is a steroid hormone secreted from the adrenal cortex in response to stress, which acts by binding to cytoplasmic glucocorticoid receptors (GRs). Dexamethasone (DEX) is a synthetic GC exhibiting immunosuppressive effects in both human and rodent models of hearing loss. While clinical evidence has shown the effectiveness of DEX for treatment of various inner ear diseases, its mechanisms of action and the optimal timing of treatment are not well understood. In the present study, intergroup comparisons were conducted based on the time point of treatment with DEX: (1) pretreatment; (2) posttreatment; and (3) pre&post-noise. The pre&post DEX treatment group showed a significant improvement in threshold shift at 1 day post-noise exposure as compared to the TTS (transient threshold shift)-only group at 8 and 16 kHz. Both TTS and PTS (permanent threshold shift) significantly reduced cochlear GR mRNA expression and increased serum corticosterone and cochlear inflammatory cytokines. The pre&post DEX treatment group showed a significant decrease in serum corticosterone level as compared to other DEX treatment groups and TTS-treated group at 3 days after acoustic trauma. Our results suggest that the timing of DEX administration differentially modulates systemic steroid levels, GR expression and cochlear cytokine expression.
Adaptive migration promotes food web persistence
Authors: Mougi A.
Published: September 2019

Interactions between diverse species that coexist in nature are of utmost interest in the field of ecology. Recent theoretical studies have shown that spatiality plays a key role in maintaining complex systems with multiple differing species. In these models, however, organisms move among habitats randomly, implying that some organisms migrate from areas of higher fitness to areas of lower fitness in a maladaptive way. Herein, a meta-community model of a food web shows that adaptive movements by organisms can play key roles in maintaining large ecological communities. Without adaptive dispersal, species are not likely to persist across habitats, particularly when systems have few habitats where local food webs are strongly coupled by high migration rates. However, adaptive dispersers can improve such low persistence greatly. By abandoning unfavourable habitats for favourable habitats, dispersers prevent regional extinction at the price of local extinction and increase their total numbers further. Hence, the inherent stabilising effect of spatiality may be larger than that expected from theoretical random movement models.
A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance
Authors: Lee Gang-Hui , Cheng Nai-Wei , Yu Hsin-Hsuan , Tsai Jen-Ning , Liu Tsunglin , Wen Zhi-Hong , Chen Bing-Hung , Fu Tzu-Fun
Published: September 2019

Lung injury is one of the pathological hallmarks of most respiratory tract diseases including asthma, acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). It involves progressive pulmonary tissue damages which are usually irreversible and incurable. Therefore, strategies to facilitate drug development against lung injury are needed. Here, we characterized the zebrafish folate-deficiency (FD) transgenic line that lacks a fully-developed swim bladder. Whole-mount in-situ hybridization revealed comparable distribution patterns of swim bladder tissue markers between wild-type and FD larvae, suggesting a proper development of swim bladder in early embryonic stages. Unexpectedly, neutrophils infiltration was not observed in the defective swim bladder. Microarray analysis revealed a significant increase and decrease of the transcripts for cathepsin L and a cystatin B (CSTB)-like (zCSTB-like) proteins, respectively, in FD larvae. The distribution of cathepsin L and the zCSTB-like transcripts was spatio-temporally specific in developing wild-type embryos and, in appropriate measure, correlated with their potential roles in maintaining swim bladder integrity. Supplementing with 5-formyltetrahydrofolate successfully prevented the swim bladder anomaly and the imbalanced expression of cathepsin L and the zCSTB-like protein induced by folate deficiency. Injecting the purified recombinant zebrafish zCSTB-like protein alleviated FD-induced swim bladder anomaly. We concluded that the imbalanced expression of cathepsin L and the zCSTB-like protein contributed to the swim bladder malformation induced by FD and suggested the potential application of this transgenic line to model the lung injury and ECM remodeling associated with protease/protease inhibitor imbalance.
Tailoring exciton dynamics of monolayer transition metal dichalcogenides by interfacial electron-phonon coupling
Authors: Nie Zhonghui , Shi Yongliang , Qin Shuchao , Wang Yuhan , Jiang Hongzhu , Zheng Qijing , Cui Yang , Meng Yuze , Song Fengqi , Wang Xiaoyong , Turcu Ion C. E. , Wang Xinran , Xu Yongbing , Shi Yi , Zhao Jin , Zhang Rong , Wang Fengqiu
Published: September 2019

With their strong light-matter interaction and rich photo-physics, two-dimensional (2D) transition metal dichalcogenides (TMDs) are important candidates for novel photonic and spin-valleytronic devices. It is highly desirable to control the photocarrier behaviours of monolayer TMDs to suit the needs of device functionalities. Here, through interfacial engineering, i.e., by depositing monolayer MoSe2 onto different oxide substrates (SiO2, Al2O3 and HfO2), we have revealed large tuning of the exciton relaxation times in monolayer TMDs. Significantly, the non-radiative recombination of MoSe2 is found shortened by almost one order of magnitude, from 160 ± 10 ps (on SiO2) to 20 ± 4 ps (on HfO2). Theoretical simulations based on ab initio non-adiabatic molecular dynamics (NAMD) method, together with temperature-dependent optical spectroscopy, identifies interfacial electron-phonon (e-ph) coupling as the leading mechanism for the lifetime tuning. Our results establish interface engineering as an effective knob for manipulating excited-state dynamics of monolayer TMDs.
Unraveling the thermodynamic conditions for negative gas adsorption in soft porous crystals
Authors: Vanduyfhuys L. , Van Speybroeck V.
Published: September 2019

Soft porous crystals (SPCs) are widely known for their intriguing properties and various counterintuitive phenomena such as negative linear compression, negative thermal expansion and negative gas adsorption (NGA). An intriguing case is the adsorption of methane in DUT-49 for which experimentally a drop in the amount of adsorbed particles was observed under increasing vapor pressure. It is yet unknown which specific systems can exhibit NGA under which thermodynamic conditions. Herein, a semi-analytical thermodynamic model is applied to determine the conditions required for NGA, including their sensitivity towards various system-specific parameters, and investigate the correlation with pressure-induced breathing. As such, it is found that certain non-breathing materials may exhibit breathing with NGA under application of a fixed mechanical pressure. Such meticulous control of multiple triggers for NGA can open the way to new applications such as tunable gas detection and pressure amplification.
Lab on paper: assay of beta-lactam pharmaceuticals by redox titration
Authors: Myers Nicholas M. , Maina Mercy W. , Were Phelix Makoto , Karwa Rakhi , Pastakia Sonak D. , Sharp Jalen C. , Luther Jamie L. , Cooper Adam , Bliese Sarah L. , Oberhof Nils , Aldulaimi Doaa , Lieberman Marya
Published: September 2019

This paper test card can identify ampicillin or amoxicillin formulations that contain <90% of the stated API content.
Photoinduced synthesis of poly(N-ethylcarbazole) from phenacylium salt without conventional catalyst and/or monomer
Authors: Kaya Kerem , Koyuncu Sermet , Yagci Yusuf
Published: September 2019

We report a new method for the photoinduced synthesis of poly(N-ethylcarbazole) (PEC).
Simultaneous detection of multiple DNA damage types by multi-colour fluorescent labelling
Authors: Torchinsky Dmitry , Michaeli Yael , Gassman Natalie R. , Ebenstein Yuval
Published: September 2019

Specific and simultaneous quantitation of DNA adducts is a major obstacle. Using repair enzymes, we present a protocol to quantify two types of DNA lesions simultaneously on the same DNA molecule and examine repair dynamics by single-molecule imaging.
Activation of olefin metathesis complexes containing unsymmetrical unsaturated N-heterocyclic carbenes by copper and gold transmetalation
Authors: Kamal Fadwa , Colombel-Rouen Sophie , Dumas Adrien , Guégan Jean-Paul , Roisnel Thierry , Dorcet Vincent , Baslé Olivier , Rouen Mathieu , Mauduit Marc
Published: September 2019

The activation of latent ruthenium complexes containing two unsymmetrical NHCs by copper and gold transmetalation leads to impressive initiation rates in olefin metathesis.
α-C–H borylation of secondary alcohols via Ru/Fe relay catalysis: building a platform for alcoholic C–H/C–O functionalizations
Authors: Zhu Qing , He Zeyu , Wang Lu , Hu Yue , Xia Chungu , Liu Chao
Published: September 2019

An unprecedented α-C–H borylation of secondary alcohols was successfully achieved and delivered various tertiary α-boryl alcohols. Several alcoholic α-C–H and C–O bond functionalizations were carried out to demonstrate this approach.
Recent advances in transition metal-catalysed cross-coupling of (hetero)aryl halides and analogues under ligand-free conditions
Authors: Ayogu Jude I. , Onoabedje Efeturi A.
Published: September 2019

The formation of new bonds is pivotal in organic chemistry and a prerequisite to life because it allows the construction of complex molecules from simple precursors.
Acrylamide in biscuits commercialised in Spain: a view of the Spanish market from 2007 to 2019
Authors: Mesías Marta , Morales Francisco J. , Delgado-Andrade Cristina
Published: September 2019

Despite mitigation strategies applied in the Spanish biscuit industry in the last decades, reformulation of traditional recipes with innovative cereals and ingredients may increase the acrylamide content in biscuits.
One-pot synthesized core/shell structured zeolite@copper catalysts for selective hydrogenation of ethylene carbonate to methanol and ethylene glycol
Authors: Ding Yu , Tian Jingxia , Chen Wei , Guan Yejun , Xu Hao , Li Xiaohong , Wu Haihong , Wu Peng
Published: September 2019

Novel hierarchical core/shell structured S-1@Cu with balanced Cu0 and Cu+ active species was synthesized via base-assisted hydrothermal chemistry and served as a robust catalyst for selective EC hydrogenation to methanol.
Probing a chemical state during ultra low impact energy secondary ion mass spectrometry depth profiling
Authors: Michałowski Paweł Piotr
Published: September 2019

Ultra low impact energy SIMS allows probing a chemical state and provides qualitative information about strong covalent bonds.
Stimulating antibacterial activities of graphitic carbon nitride nanosheets with plasma treatment
Authors: Cui Haiying , Gu Zonglin , Chen Xiaochen , Lin Lin , Wang Zegao , Dai Xing , Yang Zaixing , Liu Lei , Zhou Ruhong , Dong Mingdong
Published: September 2019

In this study, we have demonstrates that nitrogen-plasma-treated g-C3N4 nanosheet exhibits excellent and broad-spectrum antibacterial activity against eight foodborne pathogens in the absence of light illumination.
Ultrafast optical switching based on mutually enhanced resonance modes in gold nanowire gratings
Authors: Wang Yan , Zhang Xinping
Published: September 2019

An optical switch as fast as 290 fs using thick gold nanowires to achieve a modulation depth of >16%.
Polymer-based flexible NOx sensors with ppb-level detection at room temperature using breath-figure molding
Authors: Yu Seong Hoon , Girma Henok Getachew , Sim Kyu Min , Yoon Seongwon , Park Jong Mok , Kong Hoyoul , Chung Dae Sung
Published: September 2019

A direct/facile strategy for synchronizing the gas receptor and signal transport layers is demonstrated for highly sensitive flexible NOx sensors.
Facile synthesis of PdFe alloy tetrahedrons for boosting electrocatalytic properties towards formic acid oxidation
Authors: Cai Bingfeng , Ma Yanrong , Wang Shangzhi , Yi Na , Zheng Yang , Qiu Xiaoyu , Tang Yawen , Bao Jianchun
Published: September 2019

PdFe bimetal alloy tetrahedrons were prepared with the assistance of (S)-(–)-2,2′-diamino-1,1′-binaphthalene, which exhibited an outstanding electrocatalytic performance towards FAOR.
Multi-scale magnetic coupling of Fe@SiO2@C–Ni yolk@triple-shell microspheres for broadband microwave absorption
Authors: Shi Xiaofeng , You Wenbin , Zhao Yunhao , Li Xiao , Shao Zhengzhong , Che Renchao
Published: September 2019

Magnetic core@shell and yolk@shell microspheres have received extensive attention; however, the realization of microwave performance enhancement remains a critical challenge for their actual applications.
Carbon-loaded ultrafine fully crystalline phase palladium-based nanoalloy PdCoNi/C: facile synthesis and high activity for formic acid oxidation
Authors: Pan Yu , Zhu Yihua , Shen Jianhua , Chen Ying , Li Chunzhong
Published: September 2019

Ultrafine fully crystalline PdCoNi/C with abundant low coordination sites and remarkable performance as a formic acid oxidation electrocatalyst.
Controlled synthesis of glycopolymers with pendant complex-type sialylglycopeptides and their binding affinity with a lectin and an influenza virus
Authors: Tanaka Tomonari , Nakashima Keita , Tsuji Sotaro , Han Xiaoyu , Zhao Jianxin , Honda Yoshitomo , Sakakibara Keiko , Kurebayashi Yuuki , Takahashi Tadanobu , Suzuki Takashi
Published: September 2019

Glycopolymers with pendant complex-type sialylglycopeptides (SGPs) were synthesized by a post-polymerization approach. The resulting glycopolymers strongly interacted with a lectin and an influenza virus.
Polymer synthesis in non-ionic deep eutectic solvents
Authors: Ndizeye Natacha , Suriyanarayanan Subramanian , Nicholls Ian A.
Published: September 2019

Acetamide- and urea-derivative based non-ionic deep eutectic solvents in polymer synthesis.
A [4 + 1] annulation of ortho-electrophile-substituted para-quinone methides for the synthesis of indanes and isoindolines
Authors: Feng Ziwen , Yuan Zhenbo , Zhao Xiaobin , Huang Yue , Yao Hequan
Published: September 2019

Indanes and isoindolines were obtained via a 1,6-conjugated addition/1,4-Michael addition of ortho-electrophile-substituted para-quinone methides with nucleophiles in high yields and with good functional group tolerance.
Palladium decorated on a new dendritic complex with nitrogen ligation grafted to graphene oxide: fabrication, characterization, and catalytic application
Authors: Golestanzadeh Mohsen , Naeimi Hossein
Published: September 2019

Immobilized Pd nanoparticles on a new ligand, namely, tris(pentaethylene-pentamine)triazine supported on graphene oxide (Pdnp-TPEPTA(L)-GO) was introduced as a novel and robust heterogeneous catalyst for use in C–C bond formation reaction.
Natural source, bioactivity and synthesis of benzofuran derivatives
Authors: Miao Yu-hang , Hu Yu-heng , Yang Jie , Liu Teng , Sun Jie , Wang Xiao-jing
Published: September 2019

Benzofuran compounds are a class of compounds that are ubiquitous in nature.
Improved lithium ion dynamics in crosslinked PMMA gel polymer electrolyte
Authors: Hosseinioun Ava , Nürnberg Pinchas , Schönhoff Monika , Diddens Diddo , Paillard Elie
Published: September 2019

Ionic transport was investigated in a PMMA gel electrolyte by electrochemical, Raman, PFG-NMR, e-NMR spectroscopies and ab initio calculations. The presence of the PMMA matrix reduces anionic mobility and decorrelates cationic and anionic transport.
Visual artificial tongue for identification of various metal ions in mixtures and real water samples: a colorimetric sensor array using off-the-shelf dyes
Authors: Huang Yuanfang , Cheng Peiwen , Tan Chunyan
Published: September 2019

A colorimetric sensor array was constructed to detect metal ions by pattern recognition based on image analysis and absorption spectra.
Correction: Silica cubosomes templated by a star polymer
Authors: Cui Congcong , Han Lu , Che Shunai
Published: September 2019

Correction for ‘Silica cubosomes templated by a star polymer’ by Congcong Cui et al., RSC Adv., 2019, 9, 6118–6124.
Assessing TA buy-in to expectations and alignment of actual teaching practices in a transformed general chemistry laboratory course
Authors: Duffy Erin M. , Cooper Melanie M.
Published: September 2019

Inquiry-style laboratory courses, in which students engage in open-ended projects rather than a prescribed set of experimental steps (“cookbooks”), are becoming increasingly popular at the undergraduate level. Reformed curricula require reforms in training teachers; in the case of large universities, laboratory instructors are typically graduate teaching assistants (TAs). The General Chemistry Laboratory courses at a large, public, research-intensive university in the Midwestern region of the United States recently underwent a transformation from a “cookbook” to a project-based lab, and despite efforts to improve training, TAs continue to express difficulty teaching the course. To determine the source of these difficulties, we conducted multiple video observations and semi-structured interviews with seven TAs throughout one semester. We report TAs’ beliefs about what is expected of them, their philosophical alignment to perceived expectations, and a comparison of the Lab Coordinator's expectations to TAs’ actual teaching practices. We found that the TAs generally agreed with behaviors they were expected to perform, but responses to actions they were not supposed to do indicated that they were unsure of what the Lab Coordinator expected and personally believed that an ideal TA would perform those actions. This work highlights a need to clearly communicate the aims and expectations in a course and the rationale for those choices.
Facile one-pot polymerization of a fully conjugated donor–acceptor block copolymer and its application in efficient single component polymer solar cells
Authors: Park Chang Geun , Park Su Hong , Kim Youngseo , Nguyen Thanh Luan , Woo Han Young , Kang Hungu , Yoon Hyo Jae , Park Sungnam , Cho Min Ju , Choi Dong Hoon
Published: September 2019

A single component polymer solar cell with a CDABP film annealed at 180 °C showed a maximum power conversion efficiency of 5.28%, which is much higher than that (2.62%) of the device with the as-cast film.
Crystal size versus paddle wheel deformability: selective gated adsorption transitions of the switchable metal–organic frameworks DUT-8(Co) and DUT-8(Ni)
Authors: Ehrling Sebastian , Senkovska Irena , Bon Volodymyr , Evans Jack D. , Petkov Petko , Krupskaya Yulia , Kataev Vladislav , Wulf Toshiki , Krylov Alexander , Vtyurin Alexander , Krylova Svetlana , Adichtchev Sergey , Slyusareva Evgenia , Weiss Manfred S. , Büchner Bernd , Heine Thomas , Kaskel Stefan
Published: September 2019

DUT-8(Co) shows a selective structural transition for CH2Cl2vs. CHCl3 and CCl4 at 298 K.
Hollow TiN nanotrees derived from a surface-induced Kirkendall effect and their application in high-power supercapacitors
Authors: Wen Wei , Yao Jincheng , Tan Hua , Wu Jin-Ming
Published: September 2019

A surface decoration strategy was explored to trigger a nanoscale Kirkendall effect to fabricate hollow TiN nanotrees for high-power symmetric supercapacitors.
Green-emitting iridium(iii) complexes containing pyridine sulfonic acid as ancillary ligands for efficient OLEDs with extremely low efficiency roll-off
Authors: Zhang Lin , Yan Zhi-Ping , Tu Zhen-Long , Wu Zheng-Guang , Zheng You-Xuan
Published: September 2019

A pyridine sulfonic acid has been developed for green-emitting iridium(iii) compounds, which exhibit a EQEmax of 25.5% with an extremely low efficiency roll-off, and the EQE still remains at 22.9% at 20 000 cd m−2.
Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP
Authors: Nguyen Quynh-Anh Thi , Choi Juyong , Yang Jin Kuk , Lee Sang Yoon
Published: September 2019

Misfolded proteins in the endoplasmic reticulum (ER) are removed through multistep processes termed ER-associated degradation (ERAD). Valosin-containing protein (VCP) plays a crucial role in ERAD as the interaction of ubiquitin fusion degradation protein 1 (Ufd1) with VCP via its SHP box motif (228F-S-G-S-G-N-R-L235) is required for ERAD. However, the mechanisms by which the VCP–Ufd1 interaction is regulated are not well understood. Here, we found that the serine 229 residue located in the Ufd1 SHP box is phosphorylated in vitro and in vivo by cyclic adenosine monophosphate-dependent protein kinase A (PKA), with this process being enhanced by either forskolin (an adenylyl cyclase activator) or calyculin A (a protein phosphatase inhibitor). Moreover, a phosphomimetic mutant (S229D) of Ufd1 as well as treatment by forskolin, calyculin A, or activated PKA strongly reduced Ufd1 binding affinity for VCP. Consistent with this, the Ufd1 S229D mutant significantly inhibited ERAD leading to the accumulation of ERAD substrates such as a tyrosinase mutant (C89R) and 3-hydroxy-3-methylglutaryl coenzyme A reductase. However, a non-phosphorylatable Ufd1 mutant (S229A) retained VCP-binding ability and was less effective in blocking ERAD. Collectively, our results support that Ufd1 S229 phosphorylation status mediated by PKA serves as a key regulatory point for the VCP–Ufd1 interaction and functional ERAD.
At a Glance: February 2013
Authors: Brook Gail
Published: September 2019

Early Intervention: "Who Is Providing EI Services?", "In What Parts of the Country Are EI Services Provided Most?"
Academic Edge: Realizing Our Educational Future—Now
Authors: Johnson Alex
Published: September 2019

The Affordable Care Act will shake up insurance reimbursement, and audiologists and speech-language pathologists will feel the effects.
App-titude: Top Apps for Tots
Authors: Hanks Heidi
Published: September 2019

Leave your flashcards at home and try these five apps for early language learning.
App-titude: Vocal Workouts Go Mobile
Authors: Sweeney Sean
Published: September 2019

Voice apps remind and help clients to practice exercises, modulate intensity and record samples.
App-titude: Gather Around the Virtual Meeting Table
Authors: Sweeney Sean
Published: September 2019

New apps make it easier for interdisciplinary teams to track clients' learning goals and share treatment strategies.
Bottom Line: Who Can Bill Medicaid for Services in Schools?
Authors: Havens Laurie
Published: September 2019

Can a school bill Medicaid for speech-language services provided by non-SLPs? The answer depends on your state's laws.
From My Perspective: How Do We Make Interprofessional Collaboration Happen?
Authors: Rogers Margaret , Nunez Loretta
Published: September 2019

It will take a lot more than talk to really change the health care culture.
First Person on the Last Page: Dreams and Daughters
Authors: Crook Margaret
Published: September 2019

I have been a practicing speech-language pathologist for 32 years and a mom for 25 years. Dreams do come true, but mine have become even more magical because both of my daughters are also becoming SLPs.
More Than Words
Authors: Wallace Sarah , Purdy Mary
Published: September 2019

When people with aphasia can't find the right words, it can completely derail a conversation. Instruction in multimodal communication helps them slide more easily into other forms of expression when words fail them.
Know What You Don't Know
Authors: Torres Irene
Published: September 2019

Customs related to raising children can be a moving target of family tradition and generational differences. So clinicians must be strongly attuned to culture when evaluating a young child. But how do you ensure that you're culturally competent? It starts with taking a long hard look at your assumptions.
All Talked Out
Authors: Roy Nelson , Tanner Kristine
Published: September 2019

Vocal wear and tear is the greatest occupational hazard for our nation's teachers. What have we learned from them?
The Behavioral Voice-Lift
Authors: Ziegler Aaron , Hapner Edie
Published: September 2019

Learn how SLPs can help restore the youthful voice of an aging population.
Health Care Summit Identified Need for Interprofessional Education
Authors: McNeilly Lemmietta
Published: September 2019

Clinicians, researchers and administrators agree: Changes in health care delivery and reimbursement models make interprofessional education and practice a must. Here's what ASHA is doing about it.
Get Social: Build Your Career With Social Media
Authors: Coyle Tanya , Huston Mary
Published: September 2019

Do you get as excited as we do about going to big conferences like ASHA? There's so much going on: Professional learning and access to cutting-edge research. People from all over the world sharing their passion for what they do. And networking, networking, networking.
In Private Practice: Should You Become a Medicare Provider?
Authors: Samuels Barbara
Published: September 2019

Is it a good business move? Here are some factors—and the process—to consider.
In Private Practice: No More No-Shows
Authors: Merkel-Walsh Robyn
Published: September 2019

Clear policies—and sometimes penalties—will help reduce last-minute cancellations and improve your bottom line. Here are some suggestions.
Make It Work: Boost Your Productivity—and Job Satisfaction
Authors: Kummer Ann
Published: September 2019

Is administrative work sucking all the time out of your day? Try these strategies to maximize what you trained for: face time with patients.
On the Pulse: When Your Employer Makes Unethical Demands
Authors: Brown Janet
Published: September 2019

With your job on the line, handling fraudulent demands is difficult. Here are some tips.
School Matters: A Speech Lesson a Day...
Authors: Mabry-Price Lisa
Published: September 2019

Preschool classroom strategies and tips for parents may help prevent speech-language difficulties. Here are some suggestions.
Spotlight on Special Interest Group 1, Language Learning and Education
Authors: Price Lisa
Published: September 2019

Special Interest Group 1, Language Learning and Education is the only group that addresses issues related to developmental language disorders across the lifespan.
Spotlight on Special Interest Group 11, Administration and Supervision
Authors: Deruiter Mark , Hudson Melanie , Passe Melissa , Phillips Kerrilyn , Zylla-Jones Elizabeth
Published: September 2019

Special Interest Group 11, Administration and Supervision, is featured.
State Spotlight: Massachusetts Speech-Language-Hearing Association
Authors: Finnie Meredith
Published: September 2019

MSHA monitors bills introduced in the state legislature that could have a positive or negative impact on our profession in the areas of delivery of services, conditions of services or licensure.
Novel Frequency-Doubling Modulation and Control Strategy for Three-Level Full Bridge based Power Electronic Traction Transformers
Authors: Li Hongbo , Mei Wenqing , Yang Ye , Luo Wenguang , Zhang Zhixue , Zang Xiaodi
Published: September 2019

Power electronic traction transformers (PETTs) are widely investigated to substitute bulky line frequency transformers in railway traction system presently. This paper adopts the three-level topology for both grid-side cascaded converters and primary-sides of LLC resonant converters. The cascade number is reduced by half as well as isolated transformers compared to the traditional two-level configuration. Less cascade number of modular converters leaves relatively more space for electric insulation implementation, which is beneficial to PETTs in terms of the limited installation space in the train. A frequency-doubling modulation strategy for LLC resonant converters is proposed, which can enable the operating frequency of isolated transformers two times higher than the switching frequency to further reduce the transformer size without increasing the switching loss. Meanwhile the proposed modulation strategy can realize the capacitor voltage balance autonomously as well. Additionally, the control strategy of cascaded rectifiers and key parameter design guideline of LLC resonant converters are also introduced.
Control Method for Three-Phase Grid-Connected Inverter PV System Employing Unity Power Factor (UPF) Strategy in Microgrid
Authors: Naderipour Amirreza , Abdul-Malek Zulkurnain , Ramachandaramurthy Vigna K. , Guerrero Josep. M.
Published: September 2019

Microgrids (MGs) are developing owing to the rapidly growing distributed power generation systems. The MG controls the flexibility of the network to ensure the requirements of reliability and power quality are satisfied. A typical MG normally consists of dispersed generation resources, which are connected by power electronic inverters, storages, and non-linear loads. This study deals with a compensation control method of a photovoltaic grid-connected inverter using unity power factor (UPF) strategy in MG. In this case, the proposed control method can provide output currents without distortion and with the UPF. Further, it is able to increase the inverter output current to approximately 19 times of the value obtained conventionally. The proposed control method can be applied to three-phase grid interfaced converters such as DG inverters and can also be easily integrated into the conventional control scheme without installation of extra hardware. A theoretical analysis is presented and the performance of the proposed control method for a grid-connected inverter in a MG is evaluated through simulation results.
Making a Case for Local Combined Head and Power and District Heating Infrastructures within the United Kingdom Policy Landscape
Authors: Urquizo Javier , Calderón Carlos , James Philip
Published: September 2019

Planning energy infrastructure at the local level is the key to addressing some of the most difficult challenges in climate change and energy policy planning (i.e. fuel poverty) and to unlock the transformative potential of distributed energy technologies. The scientific field of urban energy and carbon modelling is becoming a fundamental instrument to estimate an energy and carbon baseline at a point in time and to quantify the impact that policy-driven technological interventions that could have on the overall carbon footprint of a city. This capability enables an evidence-based approach in which the economic case towards a low-carbon economy can be made. Transformative local distributed energy technologies such as CHP or district heating have a strong spatial component due to a need to identify synergies with adjacent properties or heating loads. Currently available domestic building energy models often do not take into account spatial information. Accessing geo-referenced data for energy modelling can also be particularly useful as validated outputs (i.e. heating and electricity loads, energy profiles) can be mapped using spatial modelling techniques that help to easily identify high and low energy consumption areas and potential synergies in local energy infrastructure planning. In Newcastle upon Tyne UK, the council is exploring the opportunities for the installation of renewable heat technologies on their own stock as a matter of urgency. Identification of potential sites and feasibility for technical and financial applicability within the UK policies will be addressed by this paper.
PISA: new design methods for offshore wind turbine monopiles
Authors: Byrne Byron W. , Burd Harvey J. , Zdravković Lidija , McAdam Ross A. , Taborda David M.G. , Houlsby Guy T. , Jardine Richard J. , Martin Christopher M. , Potts David M. , Gavin Kenneth G.
Published: September 2019

This paper provides a summary of the PIle Soil Analysis (PISA) project, completed in the UK during the period 2013 to 2018. The research led to the development of a new, computationally efficient, one dimensional design model for laterally loaded monopile foundations, particularly for offshore wind turbine support structures. The current form of the design model is applicable to monotonic loading only, but it could form a basis for extensions to cyclic loading. This short paper describes the background to the project, outlining the key research elements completed, as well as the main impacts that have been achieved. A number of publications describing the research in further detail are highlighted.
A Modified Rotator Cuff Sparing Approach to the Proximal Humerus in Antegrade Nail Osteosynthesis with Transosseous Supraspinatus Tendon Refixation
Authors: Ateschrang Atesch , Gratzer Christoph , Stöckle Ulrich , Schreiner Anna Janine
Published: September 2019

Background Due to the approach within antegrade humerus nail osteosyntheses, lesions of the supraspinatus tendon with a consecutive functional limitation of the rotator cuff (RC), insufficiencies, adhesions and chronic shoulder pain in the long term can result. The evidence respectively the study data situation is limited regarding the evaluation of this issue.

Patients/Material and Methods We are the first to present by means of a case report with a geriatric female patient and a dislocated diaphyseal humerus fracture a rotator cuff sparing osseous approach to the proximal humerus in antegrade nail osteosynthesis without harming the vulnerable supraspinatus tendon (SSP). This is possible through a limited osteotomy of the greater tubercle with the preparation of a 10 mm deep and 15 to 20 mm wide osseous SSP base. The medullary cavity is then opened for inserting the nail in an antegrade manner and closed after fracture stabilization through reposition of the attached osteotomy of the greater tubercle by means of a suture anchor, for example. The procedure also includes a biceps tenodesis. Besides the description of the intraoperative approach and procedure, the clinical and functional results were recorded by established scores as well as radiologically respectively sonographically 6 weeks (T1) and 3 months (T2) postoperatively.

Results The patient was very satisfied regarding pain and function after the modified operative procedure. The rotator cuff tests were negative and there were no impingement like symptoms or indications for an adhesive capsulitis. Range of motion as well as the Constant and (Quick) DASH-Score showed a very good function in the course. The implant was located regularly in the radiological control and the fracture showed a good osseous consolidation. A bland joint without effusion or periarticular fluid and no adhesion with the delta fascia could be presented by sonography. The RC and especially the SSP showed a normal sonographic separation. The functional results are comparable to the other publications so far.

Conclusion The described surgical technique shows a significantly less invasive approach for the implantation of an antegrade humerus nail in the case of a humerus shaft fracture with an excellent function of the affected shoulder in a short-term follow-up. This novel approach should be evaluated by means of prospective studies regarding the functional outcome to justify the establishment of this modified procedure in the long term. Other modified approaches have been depicted but are essentially differing from our described procedure with regards to the invasiveness of the vulnerable tendinous structure of the SSP respectively RC.
Hautzeichen bei rheumatologischen Erkrankungen im Kindes- und Jugendalter
Authors: Vogt Annika , Stieler Karola Maria , Blume-Peytavi Ulrike
Published: September 2019

Rheumatologische Erkrankungen können sich in einer großen Vielfalt an der Haut manifestieren. Das Spektrum reicht von flüchtigen Exanthemen bis zu tiefer Sklerosierung, Vaskulitis und Pannikulitis. Dank der Zugänglichkeit für Inspektion, Dermatoskopie, Palpation und Biopsien können dermatologische Mitbeurteilungen wertvolle Hinweise für die diagnostische Einordnung geben. Während bei einigen rheumatologischen Erkrankungen, wie kutanem Lupus erythematodes oder Sklerodermie, spezifische Hautzeichen leicht mit dem Auge zu erkennen oder mit den Fingern zu ertasten sind, sind Hautzeichen wie Exantheme, leukozytoklastische Vaskulitis oder Erythema nodosum klar definierte Entitäten, die jedoch verschiedene Ursachen haben können. Gerade im Kindesalter müssen die häufigen, transienten infektassoziierten Varianten von immunologischen Grunderkrankungen abgegrenzt werden. Die Symptome sind teilweise inkomplett oder atypisch und können weiteren Manifestationen vorausgehen, was interdisziplinäre Verlaufsbeurteilungen erfordert. Die hier vorgestellten Hautzeichen rheumatologischer Erkrankungen im Kindes- und Adoleszentenalter illustrieren den Wert einer engen interdisziplinären Zusammenarbeit.
Sicherheit von Antirheumatika in der Schwangerschaft: Empfehlungen von Embryotox
Authors: Weber-Schoendorfer Corinna
Published: September 2019

Die Innovationen in der Therapie rheumatischer Erkrankungen haben die Lebensqualität vieler PatientInnen deutlich verbessert, sodass mehr Frauen ihren Kinderwunsch planen und realisieren können. In diesem Artikel werden die Erfahrungen zu Antirheumatika in der Schwangerschaft zusammenfassend dargestellt und Empfehlungen für den klinischen Alltag gegeben.

Die Beratung zum Arzneimittelrisiko muss 2 verschiedenen Situationen Rechnung tragen: der Einschätzung einer Arzneitherapie bei ungeplanter Schwangerschaft und der geplanten Arzneistoffauswahl bei Kinderwunsch bzw. in der Schwangerschaft. Für eine individuelle Risiko-Nutzen-Einschätzung sind, neben der Vorgeschichte der Patientin, Kenntnisse zum möglichen Risiko und Erfahrungsumfang der Arzneistoffe erforderlich sowie zu Besonderheiten und Verlauf der jeweiligen rheumatischen Erkrankung in der Schwangerschaft. Das Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie (PVZ Embryotox) bietet Beratungen zu Arzneimitteln in Schwangerschaft und Stillzeit an und unterstützt die behandelnden ÄrztInnen bei der Therapieauswahl und Risikoeinschätzung.
Hochgradige Dammverletzungen evidenzbasiert reduzieren ‒ OASI Care Bundle Project
Authors: Garten Daniela
Published: September 2019

Mit dem OASI Care Bundle Project wurde ein Maßnahmenpaket zur Reduzierung geburtshilflicher Sphinkterverletzungen erarbeitet. Der folgende Beitrag erläutert die evidenzbasierten Elemente und zeigt ihre Relevanz für geburtshilfliche Einrichtungen auf.
Oxytocin bei der Geburt – wann und wie viel?
Authors: Filsinger Barbara
Published: September 2019

Das Medikament Oxytocin wird in der Geburtshilfe bei protrahiertem Geburtsverlauf präventiv eingesetzt, um maternaler und fetaler Morbidität vorzubeugen. Vor jedem Einsatz müssen individuell die positiven Effekte und die vielfältigen potenziellen Nebenwirkungen abgewogen werden. Die Autorin plädiert für interprofessionell entwickelte klinikinterne Standards, auf die das geburtshilfliche Team regelmäßig geschult wird. Ziel ist es, Betreuungskonzepte für Frauen in der Latenzphase zu entwickeln, um den unnötigen Einsatz von Oxytocin zu vermeiden.
Endocannabinoidsystem und Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Erwachsenenalter
Authors: Brunkhorst-Kanaan Nathalie , Kittel-Schneider Sarah
Published: September 2019

ADHS ist eine entwicklungspsychiatrische Erkrankung, die im Erwachsenenalter häufig unerkannt und unbehandelt bleibt. Die Folgen für die Betroffenen sind neben häufigeren Arbeitsplatzverlusten, ein erhöhtes Unfallrisiko und Schwierigkeiten in der sozialen Interaktion. Häufig präsentiert sich die ADHS im Erwachsenenalter sehr heterogen und ist in ca. 80 % der Fälle mit psychiatrischen Komorbiditäten, wie Depressionen, bipolare Störung, Angststörung, Borderline- und dissoziale Persönlichkeitsstörung sowie Suchterkrankungen vergesellschaftet. Letztere führt zu der hohen Inzidenz von Cannabismissbrauch von Patienten mit ADHS. Auf der anderen Seite wird vermutet, dass Cannabis von den Betroffenen als leichtes Sedativum im Sinne einer Selbstmedikation gegen einige Symptome des ADHS wie innere Unruhe, Rastlosigkeit und Schlafstörungen eingesetzt wird. Seit den frühen 1990er-Jahren sind zahlreiche Studien erschienen, die den Zusammenhang zwischen einer Störung des physiologischen endogenen Cannabinoidsystems und der Genese psychiatrischer Erkrankungen wie Depressionen, Angststörungen, posttraumatischer Belastungsstörung (PTBS), Schizophrenie, Suchterkrankungen und Schlafstörungen beschreiben und im Endocannabinoidsystem eine potenzielle Möglichkeit neuer pharmakologischer Behandlungsmöglichkeiten, z. B. durch den Einsatz von synthetischen Cannabinoiden, sehen. In diesem Artikel sollen grundlegende Mechanismen des Endocannabinoidsystems erklärt und die Zusammenhänge mit der Genese des ADHS anhand der Studienlage beleuchtet werden. Zudem soll ein Ausblick auf mögliche Therapieoptionen mit Cannabinoiden gegeben werden.
Ausschuss Krankenversicherung der dggö – Der
Innovationsfonds an der Schwelle zur Regelversorgung (?)
Authors: Krack Gundula , Schneider Udo , Zeidler Jan , Zöllner York
Published: September 2019

Zum Auftakt der 11. Jahrestagung der Deutschen Gesellschaft für
Gesundheitsökonomie am 18. März 2019 in Augsburg hatte der Ausschuss
„Krankenversicherung“ der dggö vier Experten eingeladen, um das Motto „Der
Innovationsfonds an der Schwelle zur Regelversorgung (?)“ zu diskutieren. In
diesem Artikel werden die Ergebnisse aus den Vorträgen der vier Experten und
die anschließende Podiumsdiskussion zusammengefasst.
COPD – Patienten-Simulationsmodell für COPD bietet Vorteile
im Vergleich zu etablierten Markov-Modellen
Authors: Potempa Christoph
Published: September 2019

Hoogendoorn et al. Broadening the Perspective of Cost-Effectiveness Modeling in
Chronic Obstructive Pulmonary Disease: A New Patient-Level Simulation Model
Suitable to Evaluate Strafified Medicine. Value Health 2019; 22(3): 313–321

Die Autoren um Hoogendoorn et al. präsentieren ein gesundheitsökonomisches
Patienten-Simulationsmodell zur Behandlung von COPD, welches geeignet ist,
die inkrementellen Kosten und Auswirkungen verschiedener Behandlungsoptionen
für diverse Subpopulationen von COPD-Patienten zu bestimmen. Das Modell
liefert damit wertvolle Informationen, die auch zur Entwicklung neuer
Behandlungsmöglichkeiten beitragen können.
Preisfindung – Ausschreibungsverfahren für Impfstoffe
drücken die Preise
Authors: Fietz Cornelia
Published: September 2019

Qendri V et al. Pricing of HPV vaccines in European tender-based settings. Eur J
Health Econ 2019; 20(2): 271–280

Impfstoffausschreibungen sind eine gängige Methode zur Kostendämpfung teurer
Impfstoffe in der Europäischen Union. Die Autoren untersuchen am Beispiel
der Impfung gegen humane Papillomaviren, wie sich die
Ausschreibungsverfahren in Europa unterscheiden und welche Faktoren die
Preisfindung beeinflussen.
Clinical and Radiologic Evaluation of an Individual with Hypochondroplasia and a Novel FGFR3 Mutation
Authors: Ramos Mejía Rosario , Aza-Carmona Miriam , del Pino Mariana , Heath Karen E. , Fano Virginia , Obregon Maria Gabriela
Published: September 2019

Hypochondroplasia (HCH), a skeletal dysplasia caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, is characterized by disproportionate short stature. The p.Asn540Lys (p.N540K) mutation accounts for ∼50 to 70% of cases of HCH, but novel FGFR3 mutations are described. We present a family with disproportionately short stature and mild radiologic findings seen in a major public pediatric hospital in Argentina. A previously undescribed heterozygous missense variant in FGFR3, NM_000142.4:667C > T; p.(Arg223Cys) was identified. The predicted phenotype correlates well with the mild auxologic and radiologic characteristics observed. In this case, disproportionately short stature raised the suspicion of skeletal dysplasia.
Influence of sand grain size and nest microenvironment on incubation success, hatchling morphology and locomotion performance of green turtles (Chelonia mydas) at the Chagar Hutang Turtle Sanctuary, Redang Island, Malaysia
Authors: Stewart Taylor A. , Booth David T. , Rusli Mohd Uzair
Published: September 2019

The nest microenvironment affects hatching and emergence success, sex ratios, morphology, and locomotion performance of hatchling sea turtles. Sand grain size is hypothesised to influence the nest microenvironment, but the influence of sand grain size on incubation of sea turtle eggs has rarely been experimentally tested. At the Chagar Hutang Turtle Sanctuary, Redang Island, Malaysia, green turtle (Chelonia mydas) nests were relocated to sands with different sand grain sizes on a natural beach to assess whether grain size affects nest temperature, oxygen partial pressure inside the nest, incubation success, hatchling morphology and hatchling locomotion performance. Green turtle nests in coarse sand were cooler; however, hatching success, nest emergence success, oxygen partial pressure, incubation length and hatchling size were not influenced by sand particle size. Nests in medium-grained sands were warmest, and hatchlings from these nests were better self-righters but poorer crawlers and swimmers. Hatchling self-righting ability was not correlated with crawling speed or swimming speed, but crawling speed was correlated with swimming speed, with hatchlings typically swimming 1.5–2 times faster than they crawled. Hence, we found that sand particle size had minimal influence on the nest microenvironment and hatchling outcomes.