bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes
Authors: Mazzotta Marco , Filetti Marco , Occhipinti Mario , Marinelli Daniele , Scalera Stefano , Terrenato Irene , Sperati Francesca , Pallocca Matteo , Rizzo Francesco , Gelibter Alain , Botticelli Andrea , Scafetta Giorgia , Di Napoli Arianna , Krasniqi Eriseld , Pizzuti Laura , Barba Maddalena , Carpano Silvia , Vici Patrizia , Fanciulli Maurizio , De Nicola Francesca , Ciuffreda Ludovica , Goeman Frauke , De Maria Ruggero , Vecchione Andrea , Giusti Raffaele , Ciliberto Gennaro , Marchetti Paolo , Maugeri-Saccà Marcello
Published: August 2020

Background

Immune checkpoint inhibitors (ICIs) provide significant survival benefits in non-small cell lung cancer (NSCLC). Nevertheless, while some patients obtain a prolonged benefit, a non-negligible fraction of patients experiences an ultrarapid disease progression. Identifying specific molecular backgrounds predicting opposite outcomes is instrumental to optimize the use of these agents in clinical practice.

Methods

We carried out an observational study with prospective design envisioning targeted next-generation sequencing (NGS) with an approved assay in 55 patients with metastatic NSCLC (Rome cohort), of whom 35 were treated with ICIs. Data from three clinically comparable datasets were collected and combined into a metadataset containing 779 patients. The datasets were related to the Memorial Sloan Kettering Cancer Center (MSKCC) cohort (tissue-based NGS) and the randomized phase II and III POPLAR and OAK trials (blood-based NGS).

Results

In patients treated with ICIs in the Rome cohort, co-occurring mutations in NOTCH1-3 and homologous repair (HR) genes were associated with durable clinical benefit. Using the MSKCC/POPLAR/OAK metadaset, we confirmed the relationship between the NOTCHmut/HRmut signature and longer progression-free survival (PFS) in ICI-treated patients (multivariate Cox: HR 0.51, 95% CI 0.34 to 0.76, p=0.001). The NOTCHmut/HRmut genomic predictor was also associated with longer survival (log-rank p=0.008), despite patients whose tumors carried the NOTCHmut/HRmut signature had higher metastatic burden as compared with their negative counterpart. Finally, we observed that this genomic predictor was also associated with longer survival in patients with other tumor types treated with ICIs (n=1311, log-rank p=0.002).

Conclusions

Co-occurring mutations in the NOTCH and HR pathways are associated with increased efficacy of immunotherapy in advanced NSCLC. This genomic predictor deserves further investigation to fully assess its potential in informing therapeutic decisions.
Disparate histopathology of sebaceous adenitis in a rabbit
Authors: Heinrich Nicole A , Chamroeun Douglas , Locke Erin
Published: August 2020

A 13‐month‐old, spayed, female rex rabbit presented with mildly pruritic, progressive patches of alopecia, erythema and scaling of the head, trunk and legs of five months’ duration. Initial skin biopsy was consistent with cutaneous epitheliotropic lymphoma, but a follow‐up skin biopsy and response to therapy revealed that the rabbit actually had sebaceous adenitis. Nearly one year after presentation, the rabbit's clinical signs remained well controlled. This case demonstrates the importance of interpreting histopathology in light of history, physical examination, supportive tests and response to therapy. It also demonstrates how cutaneous lesions may evolve over time and that serial biopsies may be required to achieve a diagnosis. Finally, this case suggests that there may be histopathological overlap between cutaneous epitheliotropic lymphoma and sebaceous adenitis in rabbits.
Are different benthic communities in Arctic delta lakes distinguishable along a hydrological connectivity gradient using a rapid bioassessment approach?
Authors: Scott Ryan W. , Tank Suzanne E. , Wang Xiaowa , Quinlan Roberto
Published: August 2020

Aquatic habitats in the Canadian Arctic are expected to come under increasing stress due to projected effects of climate change. There is a need for community-based biomonitoring programs to observe and understand the effects of these stressors on the environment. Here we present results from a 5 year annual sampling program of benthic invertebrates from lakes in the Mackenzie Delta, Northwest Territories, using a rapid bioassessment protocol. Connectivity between the deltaic lakes and main channels is a major driver of lake function and is expected to be substantially impacted by climate change. Lakes were selected along a gradient of connectivity based on sill elevation above the river. Using multivariate analyses of community structure, we determined that benthic assemblages responded to differences in connection time among lakes. This response was detected using a coarse taxonomic level that could be applied by community groups or volunteers but was stronger when invertebrates were identified to the family and genus levels. A secondary gradient was observed that corresponded to productivity gradients in lakes that are isolated from the river during summer. We show that benthic assemblages have potential use as sensitive indicators of climate-mediated changes to the hydrology of lakes in the Mackenzie Delta.
Theoretical investigation of the electronic structure and spectra of sulfur monoiodide cation, SI+
Authors: de Melo Gabriel Fernando , Ornellas Fernando R.
Published: August 2020

A manifold of singlet, triplet, and quintet electronic states of the sulfur monoiodide cation (SI+) correlating with the two lowest-lying dissociation channels is characterized theoretically at a high level of theoretical treatment (SA-CASSCF/MRCI+Q/aug-cc-pV5Z) for the first time. Potential energy curves, also including the effect of spin-orbit couplings, are constructed and the associated spectroscopic parameters and dissociation energies determined. As to the molecular polarity, we computed the dipole moment as a function of the internuclear distance and the associated vibrationally averaged dipole moments. Transition dipole moment functions were also constructed, and transition probabilities, as expressed by the Einstein coefficients for spontaneous emission, were evaluated for selected pairs of states that we identify as more easily accessible to experimental investigation. An analysis of the bonding in this system is also presented. Together with previous studies on neutral and cationic sulfur-monohalides, one has a comprehensive view of this series of molecules.
Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p
Authors: Cheng Yinqin , Hu Qiaosheng , Zhou Jie
Published: August 2020

Diabetes mellitus (DM) is a type of metabolic disorder characterized by long-term hyperglycemia. Accumulating evidence shows that long noncoding RNAs (lncRNAs) play significant roles in the occurrence and development of DM. This study intended to investigate the role of lncRNA plasmacytoma variant translocation 1 (PVT1) in rat insulinoma (INS-1) cells damaged by streptozotocin (STZ) and to identify the potential mechanisms. Firstly, PVT1 expression in INS-1 cells was assessed using RT-qPCR after STZ stimulation. After PVT1-knockdown, cell apoptosis, the contents of oxidative stress related markers, and changes in insulin secretion were detected. Results indicated that PVT1 was remarkably upregulated after STZ stimulation. PVT1-knockdown inhibited STZ-induced oxidative stress and apoptosis of INS-1 cells. Moreover, the insulin secretory capacity was notably elevated following PVT1 silencing. Subsequently, a luciferase reporter assay verified that miR-181a-5p was directly targeted by PVT1. The rescue assays revealed that miR-181a-5p inhibitor dramatically abrogated the effects of PVT1 silencing on oxidative stress, apoptosis, and insulin secretion. Taken together, these findings demonstrated that PVT1-knockdown could ameliorate STZ-induced oxidative stress and apoptosis and elevate insulin secretory capacity in pancreatic β cells by regulating miR-181a-5p, suggesting a promising biomarker in DM diagnosis and treatment.
The Importance of a Great Finish
Authors: Matsudaira Kate
Published: August 2020

How can you make sure that you are recognized as a valuable member of your team, whose work is seen as critical to the team’s success? You have to finish strong, every time. Here is how to keep your momentum up and make the right moves to be a visible contributor to the final success of every project.
Feasibility and Safely of Oral Rehydration Therapy before Upper Gastrointestinal Endoscopic Submucosal Dissection
Authors: Shiratori Yasutoshi , Ikeya Takashi , Nakamura Kenji , Fukuda Katsuyuki
Published: August 2020

Background/Aims. Preoperative oral rehydration therapy (PORT), often used before surgery, is rarely performed before endoscopy. Only a few reports of PORT before upper gastrointestinal endoscopy are available. This study is aimed at evaluating the safety and feasibility of PORT before upper gastrointestinal endoscopic submucosal dissection (ESD). Methods. We used alginade water (125 mL, Nestle Co., Kobe, Japan) for PORT. Alginade water is a flavored sports drink, which is palatable and promotes wound healing due to a high concentration of alginate. We conducted a single-center single-arm prospective feasibility study of PORT in 244 patients who underwent upper gastrointestinal ESD. The group wherein PORT was administered up to two hours before ESD (n=120) was compared with the historical control group (non-PORT group, n=120). We investigated the total fluid intake, hematocrit change, complications due to PORT, complications during ESD, ESD procedure time, and length of hospital stay in each group. Results. The average fluid intake in the PORT group was 462.6 mL. No complications were observed due to PORT and ESD, and significant differences in the ESD procedure time or hospital stay was not noted. Conclusion. PORT up to two hours before upper gastrointestinal ESD is feasible.
Unified Shear-Flexural Model for Vibration Control of Buildings Using Passive Dynamic Absorbers
Authors: Hernández-Barrios Hugo , Huergo Iván F. , Arce-León Carlos , Patlán Carlos M.
Published: August 2020

A unified design model is proposed for various kinds of passive dynamic absorbers (PDAs) attached to buildings with different lateral resisting systems. A total of five different PDAs are considered in this study: (1) tuned mass damper (TMD), (2) circular tuned sloshing damper (C-TSD), (3) rectangular tuned sloshing damper (R-TSD), (4) two-way liquid damper (TWLD), and (5) pendulum tuned mass damper (PTMD). The unified model consists of a coupled shear-flexural (CSF) discrete model with equivalent tuned mass dampers (TMDs), which allows the consideration of intermediate modes of lateral deformation. By modifying the nondimensional lateral stiffness ratio, the CSF model can consider lateral deformations varying from those of a flexural cantilever beam to those of a shear cantilever beam. The unified model was applied to a 144-meter-tall building located in the Valley of Mexico, which was subjected to both seismic and along-wind loads. The building has similar fundamental periods of vibration and different nondimensional lateral stiffness ratios for both translational directions, which shows the importance of considering both bending and shear stiffness in the design of PDAs. The results show a great effectiveness of PDAs in controlling along-wind RMS accelerations of the building; on the contrary, PDAs were ineffective in controlling peak lateral displacements. For a single PDA attached at the rooftop level, the maximum possible value of the PDA mass efficiency index increases as the nondimensional lateral stiffness ratio decreases; therefore, there is an increase in the vibration control effectiveness of PDAs for lateral flexural-type deformations.
Analysis of Vibration Control of Nonlinear Beam Using a Time-Delayed PPF Controller
Authors: Chen Yueli , Ge Juhong
Published: August 2020

This paper presents a study on the performance of a positive position feedback (PPF) controller to suppress the vibration of a horizontal beam under vertical excitation. Time delays in the control loop are taken into consideration to study their effects on the controller performance and the stable region. The integral iterative method is conducted to obtain a second-order approximate solution and the corresponding amplitude equations for the considered system. The stability of the steady-state solutions is ascertained using a combination of Floquet theory and Hill’s determinant. The maximum limits of time delays at which the system remains stable have been determined for different values of control parameters. And the effects of various control parameters on the existence of multiple-solution region are investigated. The analysis illustrates that the appearance of time delay and the elimination of controller damping coefficient are the two main factors to enhance the nonlinear characteristics of the controlled system. The points at which the steady-state amplitude of the main system reaches its minimum are studied analytically. The analyses show that the analytical results are in excellent agreement with the numerical simulations.
Mental Health and Suicide: At the Crossroad of a Static Law
Authors: Aderibigbe Titilayo
Published: August 2020

Historically, mental health has been clothed in secrecy in Nigeria. The mentally ill were sequestrated, disregarding their rights. Often victimized, they become suicidal without societal empathy and legal protection. Mental health law remains static, a Colonial legacy. Changing needs of society, socio-economic vicissitudes/depression affected the mental state of many Nigerians, which subsequently drove some to attempt suicide. Under the moribund Lunacy Act 1958, the Criminal and Penal Codes 2004, attempted suicide is criminalised, further exacerbating the psychological state of the suicidal. Government is reluctant to amend the Lunacy Act, along extant societal reality. This article examines the historical and social antecedents of the Lunacy Act, its relevance to mental healthcare; the socio-cultural factors impeding its amendment; and the Mental Health Act Bill. It concludes that these laws do not secure constitutionally guaranteed social responsibility of government. Nigeria has reached a crossroad. Citizens must demand that Government ensure reform of the mental health law.
Effects of Video Modeling for Young Adults With Autism in Community Employment Settings
Authors: Bross Leslie Ann , Travers Jason C. , Wills Howard P. , Huffman Jonathan M. , Watson Emma K. , Morningstar Mary E. , Boyd Brian A.
Published: August 2020

This single case design study evaluated the effects of a video modeling (VM) intervention on the customer service skills of five young adults with autism spectrum disorder (ASD). Verbalization of greeting, service, and closing phrases contextualized to community employment settings were the target behaviors. A systematic approach to visual analysis indicated the presence of a functional relation for all participants. Coworkers, job coaches, and supervisors successfully applied the VM intervention during the generalization condition. Maintenance probes conducted at 2 and 4 weeks indicated that most customer service skills were maintained. Results indicated VM was also effective in enhancing the quality of interactions with customers. Implications for research and practice related to the competitive employment of young adults with ASD are discussed.
Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood
Authors: Zhan Xiaoming , Zhong Xue , Choi Jin Huk , Su Lijing , Wang Jianhui , Nair-Gill Evan , Anderton Priscilla , Li Xiaohong , Tang Miao , Russell Jamie , Ludwig Sara , Gallagher Thomas , Beutler Bruce
Published: August 2020

Adenosine monophosphate deaminase 3 (Ampd3) encodes the erythrocyte isoform of the adenosine monophosphate (AMP) deaminase gene family. Mutations in this gene have been reported in humans, leading to autosomal-recessive erythrocyte AMP deaminase deficiency. However, the mutation is considered clinically asymptomatic. Using N-ethyl-N-nitrosourea mutagenesis to find mutations that affect peripheral lymphocyte populations, we identified 5 Ampd3 mutations (Ampd3guangdong, Ampd3carson, Ampd3penasco, Ampd3taos, and Ampd3commanche) that strongly correlated with a reduction in naive CD4+ T and naive CD8+ T-cell populations. Causation was confirmed by targeted ablation of Ampd3. Knockout mice had reduced frequencies of CD62LhiCD44lo CD4+ naive and CD8+ naive T cells. Interestingly, these phenotypes were restricted to T cells circulating in peripheral blood and were not seen in T cells from secondary lymphoid organs (lymph nodes and spleen). We found that reduction of naive T cells in the peripheral blood of Ampd3−/− mice was caused by T-cell–extrinsic factor(s), which we hypothesize to be elevated levels of adenosine triphosphate released by Ampd3-deficient erythrocytes. These findings provide an example in which disruption of an erythrocyte-specific protein can affect the physiological status of lymphocytes in peripheral blood.
Effect of low-dose exogenous surfactant on infants with acute respiratory distress syndrome after cardiac surgery: a retrospective analysis
Authors: Zhang Rongyuan , Wang Xu , Li Shoujun , Yan Jun
Published: August 2020

Background

Acute respiratory distress syndrome (ARDS) in infants undergoing cardiac surgery is associated with significant mortality and prolonged ventilation; surfactant administration may be a useful therapy. The purpose of this study is to evaluate the effect of low-dose exogenous surfactant therapy on infants suffering ARDS after cardiac surgery.

Methods

We conducted a case-control study of infants diagnosed with moderate-to-severe ARDS (PaO2/FiO2 < 150) after cardiac surgery. A case was defined as a patient that received surfactant and standard therapy, while a control was defined as a patient that underwent standard therapy. The primary endpoint was the improvement in oxygenation index (OI) after 24-h of surfactant treatment; and secondary endpoints were the ventilator time and PICU time.

Results

Twenty-two infants treated with surfactant were matched with 22 controls. Early low-dose (20 mg/kg) surfactant treatment was associated with improved outcomes. After surfactant administration for 24-h, the surfactant group was much better compared with the control group at the 24-h in OI (difference in average change from baseline, − 6.7 [95% CI, − 9.3 to − 4.1]) (P < 0.01) and ventilation index (VI, mean difference, − 11.9 [95% CI, − 18.1 to − 5.7]) (P < 0.01). Ventilation time and PICU time were significantly shorter in the surfactant group compared with the control group (133.6 h ± 27.2 vs 218.4 h ± 28.7, P < 0.01; 10.7d ± 5.1 vs 17.5d ± 6.8, P < 0.01). Infants in the surfactant group under 3 months benefit more from OI and VI than the infants over 3 months in a preliminary exploratory analysis.

Conclusions

In infants with moderate-to-severe ARDS after cardiac surgery, early low-dose exogenous surfactant treatment could prominently improve oxygenation and reduce mechanical ventilation time and PICU time. Infants younger than 3 months may get more benefit of oxygenation than the older ones. Randomized controlled trials are needed to explore the effect of surfactant to ARDS of cardiac surgical infants.
Surgical options for submucosal tumors near the esophagogastric junction: does size or location matter?
Authors: Huang Yi-Chun , Yeh Chun-Nan , Chen Ming-Yang , Wang Shang-Yu , Liu Keng-Hao , Tsai Chun-Yi , Yeh Ta-Sen
Published: August 2020

Background

Submucosal tumors (SMTs) of different etiologies exist from esophagus to rectum. Esophagogastric junction (EGJ) is one of the known difficult locations for tumor resection. Although minimally invasive surgery (MIS) is a well-established approach for gastrointestinal surgery, there is no consensus that MIS for resection of SMTs around EGJ is superior to laparotomy. We tried to clarify the factors that determine the surgeons’ choices between these two approaches.

Methods

From January 2002 to June 2016, 909 patients with SMTs underwent resection in our department. Among them, 119 patients (13%) had SMTs around EGJ were enrolled by retrospective review. The clinicopathological features and tumor-related parameters were reviewed and analyzed.

Results

The cohort was stratified into three groups according to the extent of gastrectomy and surgical approaches. The three groups are as following: major gastrectomy (n = 13), minor gastrectomy by laparotomy (n = 51), and minor gastrectomy with MIS (n = 55). The average tumor size was significantly larger in the major gastrectomy group than in the two minor gastrectomy groups; however, there was no difference between the two minor gastrectomy groups (5.33 cm, 4.07 cm, and 3.69 cm, respectively). The minor gastrectomy with MIS required least hospital stay and operation duration also. We re-stratify the two minor gastrectomy groups (n = 106) according to the orientation of SMTs around the EGJ into 4 zones. Most of SMTs located on the greater curvature side of the EGJ were resected with MIS (82% versus 18%), whereas SMTs in the other zones were resected more often by laparotomy (59% versus 41%). There was no surgical mortality within the cohort, while minor gastrectomy with MIS yielded least number of leakages among the three groups.

Conclusions

For SMTs around the EGJ, larger tumors (diameter of more than 5 cm) are more likely to be resected with major gastrectomy. To resect SMTs around the EGJ in a wedge-like (minor gastrectomy) fashion, tumors located other than the greater curvature side were more often resected by laparotomy. However, MIS yielded acceptable safety and surgical outcomes compared to conventional laparotomy for SMTs around the EGJ of the same size.
Percutaneous vertebroplasty with high- versus low-viscosity bone cement for osteoporotic vertebral compression fractures
Authors: Miao Feng , Zeng Xiaojun , Wang Wei , Zhao Zhou
Published: August 2020

Objective

There is no consensus on the best choice between high- and low-viscosity bone cement for percutaneous vertebroplasty (PVP). This study aimed to compare the clinical and radiological outcomes and leakage between three cements with different viscosities in treating osteoporotic vertebral compression fractures.

Methods

This is a prospective study comparing patients who were treated with PVP under local anesthesia: group A (n = 99, 107 vertebrae) with high-viscosity OSTEOPAL V cement, group B (n = 79, 100 vertebrae) with low-viscosity OSTEOPAL V cement, and group C (n = 88, 102 vertebrae) with low-viscosity Eurofix VTP cement. Postoperative pain severity was evaluated using the visual analog scale. Cement leakage was evaluated using radiography and computed tomography.

Results

There was no significant difference in the incidence of cement leakage between the three groups (group A 20.6%, group B 24.2%, group C 20.6%, P = 0.767). All three groups showed significant reduction in postoperative pain scores but did not differ significantly in pain scores at postoperative 2 days (group A 2.01 ± 0.62, group B 2.15 ± 0.33, group C 1.92 ± 0.71, P = 0.646). During the 6 months after cement implantation, significantly less reduction in the fractured vertebral body height was noticed in group B and group C than in group A (group A 19.0%, group B 8.1%, group C 7.3%, P = 0.009).

Conclusions

Low-viscosity cement has comparable incidence of leakage compared to high-viscosity cement in PVP for osteoporotic vertebral compression fractures. It also can better prevent postoperative loss of fractured vertebral body’s height.
Interpretations and comments for expert consensus on the diagnosis and treatment of heat stroke in China
Authors: Liu Shu-Yuan , Wang Qian , Lou Yun-Peng , Gao Yan , Ning Bo , Song Qing , Li Hai-Ling
Published: August 2020

Heat stroke is the most severe type of heat illness, it is often accompanied by severe multiorgan damage and has a high fatality rate. In January 2020, based on new research evidence and the experiences of Chinese experts in heat stroke, the Expert Group of Heat Stroke Prevention and Treatment of the Chinese People’s Liberation Army (PLA) and the Professional Committee of Critical Care Medicine of the Chinese PLA jointly issued a new Expert Consensus on the Diagnosis and Treatment of Heat Stroke in China. This article aims to interpret and supplement the major updates to the new consensus.
Illness Understanding, Prognostic Awareness, and End-of-Life Care in Patients With GI Cancer and Malignant Bowel Obstruction With Drainage Percutaneous Endoscopic Gastrostomy
Authors: Goldberg Jessica I. , Goldman Debra A. , McCaskey Sarah , Koo Douglas J. , Epstein Andrew S.
Published: August 2020

PURPOSE:

Malignant bowel obstruction (MBO) is common in advanced GI cancer, and MBO management, including drainage percutaneous endoscopic gastrostomy (dPEG), is palliative. How patients understand the goals of dPEG and its impact on disease is inadequately understood in the literature. Therefore, we analyzed these issues in patients with GI cancer.

METHODS:

Demographics, clinical variables, and patient outcomes were abstracted from the medical record. Illness understanding and future expectations were retrieved from palliative care notes. We described additional treatment and outcomes after dPEG and estimated overall survival (OS).

RESULTS:

From January 2015 to June 2017, 125 admitted patients with metastatic GI cancer underwent dPEG for MBO. Cancers were most commonly colorectal (34%) and pancreatic/ampullary (25%). During the dPEG admission, 32% (40 of 125) of patients had a palliative care consultation, and 22% (28 of 125) were asked about illness understanding and future expectations. All (28 of 28) reported good understanding of the advanced nature of their disease, but few were accurate about prognosis given their stage IV disease (10 of 28). Of the 117 (94%) discharged, 13% (15 of 117) received additional chemotherapy, which rarely prevented progression; half (63 of 117) had a do-not-resuscitate order; and most (101 of 117) were enrolled in hospice at death. Median time to death was 37 days (95% CI, 29 to 45 days); 6-month OS was 3.7% (95% CI, 1.2% to 8.4%).

CONCLUSION:

dPEGs are placed close to end of life in patients with advanced GI cancer. A minority of patients receive additional chemotherapy post-dPEG. Many have adequate disease understanding, but chemotherapy benefit is low, and future expectations vary. This may be an opportunity for improved communication regarding palliative procedures in advanced cancer.
Anesthesia Management for Cesarean Delivery in a Woman With Aromatic l-Amino Acid Decarboxylase Deficiency: A Case Report
Authors: Viviani Chiara , Buelli Elena , Fierro Giulia , Stiffan Sandra , Lorini Ferdinando Luca
Published: August 2020

Aromatic l-amino acid decarboxylase deficiency (AADCD) is a rare autosomal recessive disorder of neurotransmitter synthesis with lack of sympathetic autoregulation. Owing to hemodynamic regulatory dysfunction and impairment of sympathetic regulation of heart rate, anesthesia is challenging. We report the successful management of anesthesia in a 26-year-old pregnant woman presenting with a mild phenotype of AADCD. Neuraxial anesthesia was administered, as she had not developed complications previously. Thus, neuraxial anesthesia can also be used safely for a cesarean delivery with appropriate anticipation of potential autonomic disturbances and lack of adrenergic neurotransmission.
Move It or Lose It: Summarizing Peer-reviewed Evidence for Practicing What You Preach
Authors: Bowersock Allison H. , Jaworski Carrie A. , Pojednic Rachele
Published: August 2020

Physically active health care providers are more likely to provide physical activity (PA) counseling to their patients, but barriers in PA counseling exist. Common barriers include knowledge, time constraints, lack of reimbursement, as well as lack of personal habits. This article will summarize evidence-based knowledge regarding provider PA habits as a means of improving rapport, compliance, and empathy for patients when prescribing PA. Clinical pearls for successful PA counseling scenarios also will be discussed.
A Scoping Review of Multiple-modality Exercise and Cognition in Older Adults: Limitations and Future Directions
Authors: Boa Sorte Silva Narlon C. , Gill Dawn P. , Petrella Robert J.
Published: August 2020

The effects of multiple-modality exercise (MME) on brain health warrants further elucidation. Our objectives were to report and discuss the current evidence regarding the influence of MME on cognition and neuroimaging outcomes in older adults without dementia. We searched the literature for studies investigating the effects of MME on measures of cognition, brain structure, and function in individuals 55 years or older without dementia. We include 33 eligible studies. Our findings suggested that MME improved global cognition, executive functioning, processing speed, and memory. MME also improved white and gray matter and hippocampal volumes. These findings were evident largely when compared with no-treatment control groups but not when compared with active (e.g., health education) or competing treatment groups (e.g., cognitive training). MME may improve brain health in older adults without dementia; however, because of possible confounding factors, more research is warranted.
Bionomy and Nesting Behavior of the Bee Epanthidium tigrinum (Schrottky, 1905) (Hymenoptera: Megachilidae) in Trap-Nests
Authors: Gomes Angela Maria S. , Silva Cláudia Inês da , Cavalcante Arianne Moreira , Rocha Epifânia Emanuela M. , Freitas Breno Magalhães
Published: August 2020

About 85% of pollinating bees are solitary, but few are used for agricultural pollination. The Anthidiini tribe looks very promising in Brazil, in the light of ecosystem utility, but  it is still a species with poorly scientific research[EdM1] . To fill this gap studies on the bionomics of this species may collaborate on future studies on use of Epanthidium tigrinum as pollinator. Presented research results aims to describe the bionomy and the biological cycle of the bee E. tigrinum (SCHROTTKY, 1905) in pre-existing cavities. Conventional trap-nests inserted in wooden blocks were placed in covered spaces and daily observations of spontaneous nesting as well as individually tagged bees and nests incubated in B.O.D. were carried out during 11 months in Fortaleza-CE. The results showed that the competition with other species of bees for the pre-existing cavities and the lack of food resources or nest building materials are limiting factors for the establishment of E. tigrinum populations. However, once these problems were remedied, the bees showed multivoltine behavior, nesting throughout the experimental period. Data from 16 nests studied showed that bee foraging began on average at 7:50 a.m., foragers collected pollen in the morning and resin in the afternoon, took on average 15 days to complete a nest and there was a negative correlation with the temperature for the number of nests and for the number of cells constructed. The offspring took 43 days for the emergency, presented sexual ratio of 1.2: 1 (n = 66 emerged bees) and a mortality rate of 18.5%. The number of nests constructed per female ranged from 1 to 4 with an average size of 7.97 mm. It is concluded that E. tigrinum shows potential to rational rearing in trap nests aiming crop pollination. [EdM1]
Grinnelian and Eltonian niche conservatism of the European honeybee (Apis mellifera) in its exotic distribution
Authors: Medina Anderson Matos , Almeida-Neto Mário
Published: August 2020

The understanding of how niche-related traits change during species invasion have prompted what is now known as the niche conservatism principle. Most studies that have tested the niche conservatism principle have focused on the extent to which the species’ climatic niches remain stable in their exotic distribution. However, it is equality important to address how biotic specialization, i.e. resource use, changes during exotic species invasions. Here, we use the widespread European honeybee (Apis mellifera) to understand whether its Grinnelian and Eltonian niches changed in its exotic distribution using tests of abiotic and biotic niche conservatism. We found that both niche domains of the European honeybee remained stable in its exotic distribution, which means that neither the climatic niche nor the biotic specialization showed significant differences between the native and the exotic ranges. Our findings that climatic and resource use are coupled can be explained by A. mellifera’s long history of domestication and the possibility that life history traits (e.g., polyandry) may have shaped this species’ large niche over the course of evolution and therefore facilitated exotic ranges colonization.
Do Bottom-up Effects Define The Structuring Of Ant (Hymenoptera: Formicidae) Communities In A Restinga Remnant?
Authors: Lopes Marcos Vinícius Almeida , Santos Gilberto Marcos de Mendonça
Published: August 2020

Restingas are lowland sandy ecosystems located between mountain ranges and the sea. For living organisms in this ecosystem, restingas can be seen as habitats formed by islands of vegetation separated by a sandy matrix. These organisms are highly influenced by the environmental conditions and physical characteristics of the landscape, including size, connectivity and environmental heterogeneity. Given the recognized effectiveness of ants as bioindicators, this study uses these organisms as a model to assess how vegetation complexity affects ant communities. The study was carried out in the Parque das Dunas, Salvador - Bahia. Within this park, four categories of vegetation islands (Small, Medium, Large and Continuous) were delimited, where the ant fauna was sampled and the forms of vegetal life were analyzed, using the Raunkiaer analysis. A total of 69 ant species were collected from 31 genera and six subfamilies. We found a positive relationship between the diversity of plant life forms (H') and ant richness. In general, there was a significant difference in the composition of ant species in each microhabitat and between the areas of continuous vegetation and the different vegetation islands. There is a bottom up effect mediating the ant community associated with dune vegetation, the local richness of ant species responds to vegetation heterogeneity.
Insecticidal activity of essential oils of species from the genus Lippia against Nasutitermes corniger (Motschulsky) (Isoptera: Termitidae)
Authors: Santos Daiane Rodrigues , Oliveira Lenaldo Muniz , Lucchese Angelica Maria , Espeleta Alexandre De Freitas , Da Cruz Jucelho Dantas , Lordelo Maurício Santana
Published: August 2020

Lippia is one of the main genera in the family Verbenaceae, with 200 species described. Despite its richness in bioactive molecules, with several scientifically proven applications, there is little information on the insecticidal potential of its species. This study aimed to assess the insecticidal potential of essential oils from the species Lippia thymoides (Martius & Schauer); Lippia lasiocalycina (Schauer) and Lippia insignis (Moldenk) against Nasutitermes corniger (Motschulsky) (Isoptera-Termitidae). Insecticidal activity was evaluated by exposure to a contaminated surface, whereby plastic pots were lined with filter paper and imbibed in 1.5 ml of solution containing essential oils (10 µl/ml), with 10 N. corniger specimens per pot. The mortality count was performed at 24 and 48 h. The LC50 was determined by diluting the essential oils to concentrations of 0, 0.625, 1.25, 2.5, 5.0 and 10 µl/ml, which were chemically analyzed by GC-FID and GC-MS. The data indicated high toxicity for the essential oils for the Lippia species tested. The lowest LC50 (0.46 µl/ml) was recorded for L. lasiocalycina. The most common constituents were β-myrcene and (E)-ocimenone in essential oil of L. lasiocalycina, β-myrcene and limonene for L. insignis, and (E)-caryophyllene and caryophyllene oxide for L. thymoides. The results demonstrate the viability of developing biopesticides for N. corniger control.
Implementation of a logarithmic division-of-focal-plane polarimeter to quantify changes in collagen alignment at varying levels of illumination
Authors: Owen King Nathaniel , Gruev Viktor , Lake Spencer P.
Published: August 2020

We examine the impact of illumination, aperture, and sample thickness on two division-of-focal-plane (DoFP) polarimeters, one created using a standard 3 T pixel and the other with a forward-biased, logarithmic pixel. Across all measured metrics the logarithmic DoFP polarimeter was better able to track real-time changes in collagen alignment than the standard DoFP polarimeter.
Translation of Genomics into Precision Medicine with Artificial Intelligence: A Narrative Review on Applications, Challenges and Future Perspectives
Authors: Natania. S Arin
Published: August 2020

In the field of genomics, the broad availability of genetic information offered by next-generation sequencing technologies and rapid growth in biomedical publication has led to the advent of the big-data era. Integration of artificial intelligence. (AI) approaches such as machine learning, deep learning, and natural language processing (NLP) to tackle the challenges of scalability and high dimensionality of data and to transform big data into clinically actionable knowledge is expanding and becoming the foundation of precision medicine. In this paper, we review the current status and future directions of AI application in genomics within the context of workflows to integrate genomic analysis for precision cancer care. The existing solutions of AI and their limitations in cancer genetic testing and diagnostics such as variant calling and interpretation are critically analyzed. In addition, the present paper highlights the challenges to AI adoption in digital healthcare with regard to data requirements, algorithmic transparency, reproducibility, and real-world assessment, and discusses the importance of preparing patients and physicians for modern digitized healthcare. We believe that AI will remain the main driver to healthcare transformation toward precision medicine, yet the unprecedented challenges posed should be addressed to ensure safety and beneficial impact to healthcare.
A legislação e a gestão para redução de riscos relacionados a inundações no município de São Paulo/SP
Authors: Amaral Rosangela , Ross Jurandyr
Published: August 2020

As inundações em áreas urbanas causam problemas relacionados ao tráfego, prejuízos e danos em áreas comerciais e residenciais. Historicamente, apesar de diversas legislações ambientais restringirem o uso das planícies fluviais, muitas dessas áreas foram ocupadas e regularizadas perante os governos locais. A imprecisão e sobreposição das leis também facilitaram interpretações errôneas e infrações. Esse artigo tem como objetivo analisar os instrumentos de gestão de riscos previstos na legislação brasileira e sua aplicação em áreas recorrentemente atingidas por inundações. O estudo de caso foi aplicado à Bacia do Córrego Ipiranga, em São Paulo/SP, onde foram constatados 82 eventos de inundação em um período de 52 anos, predominantemente no período entre 2010 e 2017, com registro de danos humanos, materiais e econômicos. Diversas medidas estruturais foram empregadas até o momento, mas não tiveram eficácias suficientes para solucionar os problemas. Embora algumas leis indiquem readequações de uso nos espaços atingidos pelas inundações, essas mudanças raramente ocorrem. Observa-se que ao longo do tempo, a legislação que envolve o fenômeno da inundação apresenta uma mudança de paradigma, onde o foco, inicialmente voltado à proteção ambiental das áreas de preservação permanente, migra para a gestão de riscos de desastres.
La crónica deportiva como recurso de escritura en ELE/L2. Un enfoque procesual
Authors: Núñez-Román Francisco , Emilio J. Gallardo-Saborido Emilio J. Gallardo-Saborido
Published: August 2020

This paper stands up for the defence of writing as a hugely valuable resource for teaching Spanish as a Foreign Language or a Second Language. Specifically, it pursues two general targets: a) to highlight the importance of considering writing into the classroom of Spanish as a Foreign Language as a process that has to be constantly coached and developed; b) to emphasise how this way of teaching provides pedagogical benefits that go further the development of the writing ability itself, since it has an impact on other students’ general cognitive features. Methodologically, this text begins with a literature review that theoretically underpins the proposed targets, and, subsequently, our didactic proposal is exemplifiedby the use of a specific type of text (the match report). Then, a practical teaching resource is obtained as final result, which is supported by the recent literature on this issue. Finally, this contribution aspires to be implemented in different educative contexts by teachers of Spanish as a Foreign Language.
Letters of Bertrand Russell and Wincenty Lutosławski on Immortality, Matter and Plato
Authors: Mróz Tomasz
Published: August 2020

Wincenty Lutosławski (1863–1954) was internationally recognized in the academic world as a prominent Plato scholar. His fragmentary correspondence with Bertrand Russell is presented in this paper. Before World War II he initiated an exchange of letters with Russell on issues such as reincarnation, but the replies he received were laconic and discouraging. This changed, however, after the war when Russell published his History of Western Philosophy. Despite their different philosophical positions, Lutosławski’s opinion on this work as a whole was favourable, in particular the chapters on Plato. Such an assessment was the exception rather than the rule for that book, and knowing Lutosławski’s general recognition in Platonic studies, Russell forwarded the letter to his publisher.
Lo bello, lo sublime y lo siniestro en “Fragmento de un diario”, de Amparo Dávila
Authors: Cabrera Espinosa Claudia
Published: August 2020

La obra de la escritora mexicana Amparo Dávila (1928) ha sido leída y estudiada de manera intermitente durante los últimos sesenta años. Gracias a la edición del Fondo de Cultura Económica de sus Cuentos reunidos, de 2009, la autora zacatecana ha obtenido nuevos lectores. Asimismo, durante la última década la crítica nacional e internacional se ha interesado nuevamente por su narrativa. No obstante, poco se ha explorado el vínculo entre sus relatos y la filosofía. Este trabajo propone establecer un diálogo entre “Fragmento de un diario”, uno de los cuentos que conforman Tiempo destrozado (1959), y la filosofía de Immanuel Kant, Longino y Eugenio Trías en torno a lo bello, lo sublime y lo siniestro, considerando también las aportaciones de Sigmund Freud acerca de lo ominoso.
Función de la crítica inmediata
Authors: Nadal Josep Maria
Published: August 2020

El presente artículo reflexiona sobre la crítica inmediata y generalista, aquella de los suplementos culturales de periódicos, con el afán de desvelar algunos de los distintos límites, funciones y deberes del crítico literario, entre otros, el lugar desde dónde se escribe, la identificación del público o su función periodística.  Para ello se hace hincapié en una serie de condicionantes que gravitan sobre el crítico, en especial, el sentido y  posibilidades de su propia crítica enmarcada ésta en una crisis crónica financiera y de modelo de la prensa escrita. La asunción de riesgo intelectual y la aceptación de una responsabilidad primordial por parte del crítico pasa por redefinir el panorama de lo contemporáneo.
Development of Inchworm Type Pipe Inspection Robot using Extension Type Flexible Pneumatic Actuators
Authors: Kusunose K. , Akagi T. , Dohta S. , Kobayashi W. , Shinohara T. , Hane Y. , Hayashi K. , Aliff M.
Published: August 2020

In the case of damp and wet pipes, pipe inspection robots using pneumatic actuators offer advantages such as no electrical leakage and short circuit. In the previous study, a robot consisting of sliding/bending mechanisms using parallel arranged three extension type flexible pneumatic actuators and two holding mechanisms was successfully developed. In order to use the robot in thinner pipe, a novel and simpler propulsion mechanism utilising the difference of frictional force moving forward and backward are proposed and tested in this work. There are two mechanisms, which are “wriggling type” and “cilia type”. The “wriggling type” mechanism moves forward by wriggling its body while the “cilia type” mechanism moves by using plate type cilia that covered on the mechanism. Both mechanisms have been tested in the pipeline. As a result, it can be confirmed that the cilia type propulsion mechanism can travel in the pipe with accumulated water. It can be found that the mechanism can easily travel through corners while twisting its body by giving bending motion toward any direction.
James Cresswell, Culture and the Cognitive Science of Religion
Authors: Kapitány Rohan
Published: August 2020

James Cresswell, Culture and the Cognitive Science of Religion
WORKING PAPER RESPECTO A LA RELACIÓN ENTRE LA IMAGEN DE MARCA Y LA INTENCIÓN DE COMPRA DE ESTABLECIMIENTOS MINORISTAS DE BIENES DE CONVENIENCIA
Authors: Martinez Riaño Fernando
Published: August 2020

Entendiendo que el presente documento constituye un  cuyo propósito es alojar el avance de los proyectos de investigación desarrollados en la Maestría de la IUPG, bajo la categoría de "literatura gris" proyectado a un artículo publicable en revista indexada, el resumen de este documento consiste en: En el estudio de establecimientos comerciales, la investigación de imagen de marca y  se convierte en un concepto importante en un entorno competitivo por la globalización. Por esta razón, el presente estudio tiene como objetivo la relación entre la imagen del establecimiento minorista de bienes de conveniencia entendidas como cacharrerías y la intención de compra, ubicadas en Bogotá.
Working paper respecto de la Percepción del Product Placement en Colombia
Authors: Martínez Tobar Andrés Enrique
Published: August 2020

Entendiendo que el presente documento constituye un "Working Papers" cuyo propósito es alojar el avance de los proyectos de investigación desarrollados en la Maestría de la IUPG, bajo la categoría de "literatura gris" proyectado a un artículo publicable en revista indexada, el resumen de este documento consiste en:  El uso y colocación de marcas comerciales como herramienta publicitaria y estratégica de mercadeo en los medios audiovisuales ha tenido un crecimiento progresivo en los últimos años, y se ha vuelto más atractivo para el sector publicitario dado a los bajos costos en los que se maneja el product placement y la atencion llamativa del consumidor, debido principalmente a su capacidad de ser menos invasiva al transmitir la información, (McAllister & Giglio, 2005) En ese sentido, esta investigación tiene como objetivo analisar la percepción de dicho fenomeno comercial en el ambito del cine colombiano con el fin de mejorar el estado de conocimiento y efectividad de esta técnica. Para tal propósito, el metodo de investigación corresponde a un diseño descriptivo correlacional, empleando como medio de recolección de información la encuesta  autoadministrada cuyos criterios de inclusión de participantes consisten en personas que hayan visto cine colombiano en los ultimos tres meses entre los géneros cinematográficos más taquilleros: la comedia, el drama y el terror, se espera aportar información a la comunidad laboral y académica respecto al uso adecuado de esta práctica. 