bluuebunny/crossref_metadata_2025 huggingface dataset:
INTELLECTUAL PROPERTY MANAGEMENT IN CHEMICAL, BIOLOGICAL & PHARMACEUTICAL SCIENCE
Authors: Sharma Dr. Ram Babu , Kaur Amardeep , Deepak Mr. , Mittal Dr. Payal
Published: June 2024

Creating a new kind of formulation, coined any novel use of any chemical compound, any alteration in the step of a process – chemical engineers and pharmacists are continuously revolutionising these above-mentioned things. This revolution is proving helpful in creating the intellectual property- inflatable benefits whose advantage can be taken by an enterprise to add more values. The IPR’s are impalpable in nature and are confidential to the creator or inventor. In this era of globalisation, global trade practises are now focusing on IPR’s throughout the world. These rights provoke the creator and provide him/her confident. Strong Intellectual property rights impart funding in developing the knowledge and ultimately provoke innovation. Five types of IPR have been recorded which includes copyrights, trademarks, patents, trade dress & trade secrets. A patent is related to all the uses of that particular concept. In simple words, it conveys how that particular article works and how it is made. A patent provides the legal ownership for an article and also a monopoly in relation to enhance the innovation of a product or process. Pharmaceutical companies are much indulging themselves in obtaining durable and sustainable patents to secure their products that can be copied by other easily once known.
ARTIFICIAL INTELLIGENCE (AI) IMPLEMENTATION IN PHARMACEUTICAL INDUSTRY
Authors: S Jayanthy. , R Anuciya. , K Sofiya. , S Santhosh. , D Kaviyarasan. , Kannaiah Kanaka Parvathi
Published: June 2024

Artificial Intelligence [AI] technology has started recently to improve the various sectors in pharmaceutical industry. It helps to minimize the problems arises in the medical and health care field. It includes various technologies such as neural networks, machine learning, etc. Artificial Intelligence has been brought to different field which helps in analysing and solving issues in short time rather than taking huge labour work and long period time. In pharmaceutical industries, Artificial Intelligence (AI) can be implemented in various departments involves production, drug discovery, clinical trials, pharmacovigilance and in marketing management. AI has both advantages and disadvantages. A 'Bio-AI' revolution is taking place in the pharmaceutical industry. This revolution has the potential to significantly reduce both the time and the cost of medication development. The capacity of AI approaches to sort and analyze massive data sets allows for the application of these techniques to improve research and development efficiency as well as efficiency at various phases of medication development. AI system has been established in different companies such as Pfizer, GSK, Sanofi, Novartis, Roche, Merck.
BIO-MEDICAL WASTE MANAGEMENT DURING COVID-19
Authors: S Bhoomika. , R Jawahar Rohith. , M Mohammed Abbas. , M Abdul Kaleem. , Kannaiah Kanaka Parvathi
Published: June 2024

The COVID 19 is also known as Corona virus pandemic; It is a global destruction which was caused by severe acute respiratory syndrome coronavirus 2(SARS-COV-2). During these prevalent times proper disposal of medicine waste is essential to minimize the spread as infection. People disposed these ways into regular trash can (i.e) along with household trash and was heated like any other domestic waste. The objective is to suggest the collection of these waste from domestic and protect their natural resources like water, soil and include animals from the effect of SARS. Different dimensions of biomedical waste (BMW) Management during COVID Pandemic including existing guidelines infrastructure operational practice and aspect of waste handles.
DATA INTEGRITY ISSUES, STATISTICAL TRENDS AND UTILIZATION OF ALCOA+ IN PHARMACEUTICAL INDUSTRY
Authors: Shirkoli Mrs. Nisha S. , Sutar Mrs. Kishori P. , Japti Mr. Veerkumar P.
Published: June 2024

Data integrity is critical to regulatory compliance, and the fundamental reason for 21 CFR Part 11 published by the U.S. Food and Drug Administration (FDA). Good documentation frames are an essential aspect of good manufacturing practises (GMP) in pharmaceutical enterprises because they play a vital part in the sanity of data preservation and its development, certifications, registrations, commodification, and life-cycle governance for pharmaceutical goods. Data integrity is a key concern in the regulated pharmaceutical sector due to observations and results due to inappropriate record keeping practices or data manipulation. In the present review article, data is collected from various online sources which includes articles, CFR and WHO guidelines and statistical data from Blogs. The articles have been thoroughly gathered and reviewed from a variety of databases and indexed journals. An upsurge in data integrity breaches in 2019 led regulatory organisations such as the WHO and FDA to issue guidance on effective documentation practices. The present review article will help researchers to understand what is data integrity? Its importance in pharmaceutical industry, ways to reduce the data integrity issues by utilizing concept if ALCOA+ and recent WHO guidelines for data integrity issues.
ADVANCED TOPICAL DRUG DELIVERY SYSTEM CONTAINING FENOPROFEN OINTMENT FOR RHEUMATOID ARTHRITIS
Authors: Gineetadevi Mrs.
Published: June 2024

Rheumatoid Arthritis (RA) is a chronic, Inflammatory autoimmune disease. That initially affect the small joints of patients, and progression occurs in large joints and ultimately to the eye, skin, heart, kidney, lungs. frequently when the bone and cartilage get destroyed then ligaments and tendons got weaken. The risk factors are age, gender, genetic and the environmental exposure (air pollutants, smocking cigarette smoking). In this disease mostly NSAID’s drugs are used for reducing the pain and inflammation. The fenoprofen is propionic acid derivative NSAID’s class of COX-1 selective and non-selective inhibitor and it come into II class of biopharmaceutical classification (BCS) which are poorly water soluble. The main purpose of this study to prepare a fenoprofen ointment for topical application to treat Rheumatoid Arthritis (RA). Ointment is prepared by fusion method the preparation contains different excipients like gelling agent, surfactants, ointment bases. Ointment base is prepared by the melting of some ingredients are wool fat, cetostearyl alcohol, hard paraffin, white soft paraffin, or yellow soft paraffin sun flower wax. Nature of ointment base selection is very important because it control the performance of formulation. The formulation was prepared and evaluated for its Physicochemical properties, stability study, spreadability, drug content, PH studies, viscosity of the ointment. The ointment base act as carrier or vehicle for the medication. All the prepared formulation were evaluated for its physicochemical parameter and all the results obtained were within the limits. As compared to the standard preparation as per IP, USP, the formulation.
FIBRIN GLUE: A MODERN APPROACH TO MEDICAL SOLUTIONS
Authors: Alam Dr. Faruk , Nag Dr. Mrinmoy , Yakin Dr. Josef , Sarma Dr. Atanu , Pathak Dr. Bhaskar Jyoti
Published: June 2024

This chapter provides an update on the current market for hemostats, adhesives, and sealants, and compares them to other products. It also includes a review of a year's worth of articles on fibrin sealant, categorized by frequency of events. Scientists and clinicians have been working on creating a low-cost, widely usable substance for sealing and dressing wounds. A topical biological adhesive called fibrin glue which imitates the last stages of coagulation in its action. The substance is made up of concentrated human fibrinogen mixed with calcium chloride and bovine thrombin. It helps with tissue closure and hemostasis without causing inflammation. Fresh frozen plasma can be used to make the fibrinogen component, reducing the risk of transfusion-transmitted illnesses. A commercial product called vitagel is available for this purpose. Using a polyglycolic acid sheet coated with fibrin sealant and rubbing fibrinogen into the defect area has shown the best results in preventing postoperative air leakage. Chest tubes have also been used to drain air leaks patched with polyglycolic acid sheets and fibrin sealant in lower-risk patients.
IMPACT ON CHINESE BRANDS IN INDIA DUE TO GEOPOLITICAL TENSIONS BETWEEN INDIA AND CHINA
Authors: Sharma Dr. Samarth , Garima Ms. , Garg Dr. Pallavi Sharda , Singh Dr. Archana , Kumar Dr. Nitendra
Published: June 2024

China and India's recent geopolitical difficulties have had a substantial influence on their commercial relationship, especially the perception of Chinese products in the Indian market. This research seeks to explore Indian buyers' perceptions of Chinese companies after the geopolitical tensions between China and India. The study intends to investigate how geopolitical tensions have changed Indian customers' opinions of Chinese businesses, as well as if these impressions have influenced their purchasing decisions. The study will employ a mixed-methodological approach that will include both qualitative and quantitative methods. In-depth interviews with Indian customers will be conducted as part of the qualitative study to better understand their perspectives of Chinese companies in the present geopolitical climate. This research will help to understand the complexity of the China-India relationship. The study's results will be helpful in formulating effective strategies to manage the difficulties and capitalize on the possibilities given by the current geopolitical environment. This research will help you manage the complexity of the China-India relationship.
ANALYSIS OF TRENDS IN FARMING BETWEEN FARMERS OF ODISHA AND THE FARMERS OF STATES OF THE NORTH EAST OF INDIA
Authors: Dash Dr. Debasis
Published: June 2024

As compared to the developed countries, there has been comparatively less development in technology in India and the adaptation of it if any is very slow. But, recently the agriculture in India has witnessed monumental rise in the research and development activities. This has had a great impact on the productivity and household income of farmers. Odisha, is an agrarian state that has 70% of the population engaged in activities related to agriculture. The farming patterns of Odisha are very similar to states that are in the North East of India. Since proximity to the sea and abundance of rainfall is regularly witnessed by India’s many states of the eastern region, they have similar soil types if not same.
A STUDY ON USERS’ AWARENESS LEVEL TOWARDS M WALLETS
Authors: Rani Dr. Radha , Priyanka Ms. , Khurana Isha
Published: June 2024

Daily lives of people today revolve around their smartphones. Technological advancement, smart phones have evolved into devices where mobile users can make payments via a phone-installed application. The present study aims to explain the types of M wallets and its usage, as well as various factors that persuade the decision of users to adopt M wallets and various risk and challenges by the users of M wallets. A organized form was spread to more than 150 and full information was collected from 130 respondents. The study revealed that Paytm is the most preferable M wallet followed by Googlepay. Security is the main concern for the users while using any type of Mobile Wallet. The M Wallet service provider companies have to identify the requirements of the users and fulfill them.
TALENT MANAGEMENT IN THE WORLD OF EDUCATION
Authors: Patro Udaya Sankar , Panda Tapaswini , Sahoo Dr. Smruti Rekha
Published: June 2024

Talent management is the process of attracting, developing, and keeping personnel by ensuring a pipeline of qualified and competent individuals. The lack of skilled and competent faculty is the biggest problem facing educational institutions. Institutions are now concentrating on how to retain talent and develop it as a consequence. When institutions are in danger of experiencing a talent crisis, talent retention is not only a management priority but also a need for the institutions. Benefits, welcoming workplaces, spouse employment prospects, start-up and resources, and salary are significant elements that affect teacher retention and recruitment. This study paper offers a few tactics that organisations may use to draw in and keep the greatest talent that is available to them.
ROLE OF SEARCH ENGINE OPTIMIZATION: IN DIGITAL MARKETING
Authors: Patil Dr. Umeshwari P. , Atwadkar Prof. (Dr.) Sudhir
Published: June 2024

Search Engine Optimization (SEO) is an inbound marketing strategy that helps to increase the amount of traffic on a particular website. It revolves around taking advantage of AI or Bots like the crawlers that constantly search for data, to increase the overall ranking of your website. It can be used in good ways which can easily boost the company and in malicious ways which can harm the company and its competitors. Many companies like Amazon, Spottily, eBay, etc. use SEO as their source of advertisement.
CHALLENGES FACED BY THE MICRO, SMALL AND MEDIUM ENTERPRISES (MSME) WITH REFERENCE TO COIMBATORE CITY
Authors: C S Shrija , Pavithra M.A.
Published: June 2024

Micro, Small and medium enterprises (MSMEs) are considered as pillars of the Indian economy because of their significant contribution to GDP, exports and job creation. MSMEs started with the establishment and growth of the Indian card and coir industry, as well as various rural industries. The following are the objectives of the study. (i) to find out the challenges facing by the MSME and to offer suggestions to the MSME to overcome the issues and for their development. The researcher had taken Coimbatore for this present study. Because of Covid – 19 lockdown many industries were closed. After the third wave in Tamil Nadu, all the business have come-up with the same production and sales. Researcher had taken 70 micro, small and medium enterprises, adopted convenient sampling method. The study concluded that very few MSME are having sub contract from the large scale organization for materials, machines and labour. They may not have the material issues, they are having some other issues like qualified labour. The suggestion which given by the author will be use full to the MSME owners to develop their business.
USE OF CHATGPT IN HIGHER EDUCATION TO ASSIST ADMINISTRATIVE STAFF: A REVIEW
Authors: Bhiwandkar Apoorv , Muley Dr. Pranjal
Published: June 2024

ChatGPT is an AI-powered natural language processing tool, you may converse with a chatbot in a way that is similar to that of a human being while also doing a lot more. The language model may help you with things like writing emails, essays, and code as well as provide answers to your inquiries. All institutions consist of non-teaching which carry out menial jobs but with the help of this technology they can be trained in such a manner that they can take up jobs like writing circulars, emails, notices, MOU’s etc covering all administrative work in a professional manner and with sophisticated language. The purpose of the research is to analyze the role of ChatGPT in administrative activities such as drafting circulars, emails, notices in professional and decent way. This research is based on secondary data and exploring new prospects for administrative staff of Higher education.
ANALYSIS OF FUTURISTIC TRENDS IN INDIAN BANKING SECTOR
Authors: Ghadage Dr. Avinash , Kole Prof. Indrajeet
Published: June 2024

The banking sector is crucial to the global economy since it helps with financial transactions and offers crucial services to people, companies, and governments. Banks are financial institutions that take deposits, lend money, and provide their clients with a range of financial goods and services. Now a days banking industry is undergoing a rapid transformation driven by technological advancements, changing customer expectations, and evolving regulatory landscapes. This study explores the future trends shaping the banking sector, revealing a paradigm shift from traditional banking system to innovative, technology-driven financial ecosystems. This chapter focuses on the future of banking as well as some of the newest trends in digital banking.
REVISIT REVIVE AND RESTORE
Authors: Sarkar Smita , Sarkar Rupa
Published: June 2024

Sustainable development is the development of the present with the judicious use of the resources so that the future generation is not harmed. Recent development should not be at the cost of the next generation rather it should be the legacy which should be handed to our heirs or successors. Sustainable Development was a concept nurtured in 1987 by the World Commission on Environment and development. The holistic and ecological view is laid importance rather than the mechanistic view where life was led mechanically fulfilling only our self-centred goals. Human beings are so selfish that we forget our ethical obligations to protect our biodiversity. The new guideline is an attempt to revisit the old technology, system and revive the strategies and planning through modern measures in order to achieve the goal of restoration. The restoration of aesthetic values can lead the world dynamically towards an optimistic approach of a better world. Sustainable development can stop the detrimental impact of pollution, climate change and also establish laws of equality and justice so that the irreparable damage can be judiciously balanced. Careful planning can shift the mankind from a world of dominance to a world of coexistence. Forests preceded mankind but deserts shall follow and we would leave a scorched planet if the resources are not used judiciously. Deteriorating ecosystem with world-wide loss of biodiversity has led to conservative challenges. We can see certain changes already spreading its claws to encroach upon the world like the melting of ice caps, rising of water table due to the global warming. Less rainfall or droughts and frequent floods are the impact of climatic changes which mankind has already started experiencing. Reviving these situations by 2030 is undertaken globally by the environmentalists. All need to join hands in this rescue work as we have threatened ourselves with death by misusing and depleting the resources.
ARTIFICIAL INTELLIGENCE – EMERGING MARKETING IN ECONOMIES, CHALLENGES, OPPORTUNITIES, WITH INTEGRATED DEVELOPMENT OF SMES IN PMS
Authors: Anitha M. , S. Sakthivel Dr. , Thirunavukarasu K. , Leo Raju Dr. , S. SathishBabu Dr.
Published: June 2024

When it comes to connecting with clients at the BOP (Base of the Wealth Pyramid), technology has been identified as a crucial tool for achieving the Global Sustainable Development Goals for emerging economies. Provide a practical recommendation for practitioners, AI developers, and policymakers with regard to adopting and regulating AI usage in marketing, particularly in emerging economies, by concentrating on the ramifications and frequently disregarded negative elements. The current obstacle to AI application in India is PMS (Public Manufacturing Sector) and examines how they are related. The DEMATEL approach has been used in the study to identify the cause-and-effect group factors. Nonetheless, there are various examples of how AI is extending opportunities and assisting in the attainment of the Sustainable Development Goals in the most recent applications and trends in emerging economies. It also clarifies how investors, clients, and governments may maximise its benefits while avoiding its hazards. When handled well and with appropriate safety measures in place, AI can help private investment to alleviate poverty and enhance lives at a rate that was unthinkable just a decade ago. Explore the obstacles that SMEs (Small and Medium-Sized Entrepreneurs) experience in the AI transformation process in more detail and offer solutions. Lastly, we suggest a study programme based on environmental threats and technological obstacles faced by SMEs using PMS.
AN EVOLUTIONARY APPROACH USING ML IN SDN ARCHITECTURE
Authors: V Keerthika , Shanmuganathan Harinee , A Geetha , Munirathinam Deepak
Published: June 2024

The number of devices linked to the network is increasing dramatically in the current day. The complexity of network administration is rising as more IoT devices tend to use the internet to access the world. In order to compete with the current network technologies, traditional networking will not be sufficient. To handle and analyse the data, it is vital to use big networks and data centers. Self-Driven Networks (SDN) and Software Defined Networks (SDN) play an important part in this, aiding in the problem-solving process and enhancing network performance through the use of ML approaches. The main aim of this paper is to create a unique architecture that seamlessly integrates latency, bandwidth forecasting, and QoE estimation into the applications. The overall classification of the traffic is done based on the data from the SDN controller, this classification is used in predicting the traffic in each network route and helps in finding the optimum routes.
ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF JASMINUM MULTIFLORUM LEAVES
Authors: V N V L Suvarchala Reddy , Ganga Raju M. , Arkprabha N. , Manasa P. , Pushyami Sudha D.
Published: June 2024

Jasminum multiflorum, belonging to the Oleaceae family, is a significant medicinal plant used to treat a variety of illnesses. In the current investigation, an effort was made to examine the anti-inflammatory and analgesic results of methanolic extract of the Jasminum multiflorum in various animal models. Acute toxicity studies revealed that the extract was safe in doses up to 2000 mg/kg.For this study, two doses were selected:200 mg/kg and 400 mg/kg bodyweight. Utilizing carrageenan-induced paw edema in albino rats and other animal models, anti-inflammatory effectiveness was assessed, as was analgesic effect with the hot plate technique and tail clip method at doses of 200 and 400 mg/kg bd.wt. in healthy albino rats. The protein denaturation approach was used to achieve in vitro anti-inflammatory effects. MEJM at two doses such as 200 mg/kg bd.wt. and 400 mg/kg bd.wt, produced significant (p <0.01) anti-inflammatory activity in the animal models, which was contrast with the standard drug indomethacin. The present findings exhibited a concentration dependent inhibition of protein (albumin) denaturation by the extract. The effect was plausibly due to the flavonoid’s contents in the extract. Methanolic extract of Jasminum multiflorum significantly increased the latency of paw licking in hot plate method and increased the latency of tail licking in tail flick method. The results suggest that methanolic extract of Jasminum multiflorum leaves possessed potent anti-inflammatory and analgesic properties, presumably as a result of chemical constituents like sterols, triterpenoids, and flavonoids. The methanolic extract of Jasminum multiflorum exhibits anti-inflammatory and analgesic properties, as demonstrated by the aforementioned findings.
UNLOCKING HOPE: THE JOURNEY OF CANCER THERANOSTICS
Authors: M. Sunitha Reddy Prof. , K. Anie Vijetha Dr.
Published: June 2024

Cancer theranostics is an integrated approach that combines diagnostics and therapeutics in the treatment of cancer. It aims to personalize cancer treatment by using diagnostic techniques to identify specific biomarkers, molecular profiling, and imaging modalities to determine the characteristics of a patient's tumor. This information is then used to guide the selection of the most effective and targeted therapies.
IMPORTANCE OF SIMULATION-BASED TRAINING, COMMUNICATION SKILL, SELF-EFFICACY AND CLINICAL COMPETENCE IN NURSING STUDENTS- REVIEW ARTICLE
Authors: Nancy Domingo Mrs. , Nirwani Chaudhari Ms. , Kajal Gathe Ms. , Priti Nakhale Ms.
Published: June 2024

It was observed that nursing students appeared to have low confidence and significant levels of anxiety while learning fundamental skills and taking skills assessments. Can simulation-based learning help students become more confident and perform better? In general, its efficiency is unknown. However, possible unsupportive aspects include examiners' unannounced verbal and non-verbal expressions, their fundamental attitudes regarding students' performance, and technology fear. Simulator-based instruction was proven to have a significant favorable effect on students' achievement outcomes. One area where this kind of teaching and learning style could be quite beneficial is the learning of nursing skills.
SUSTAINABILITY IN HEALTH AND HEALTH CARE PROVISION
Authors: Kharkongor Baiaipynkmen
Published: June 2024

Development comes with its own effects. People have now started to realise the importance of preserving the God given resources for the generation to come. Thus, the concept of sustainable development started to evolve though it has been developed since the 17th century. The Brundtland Report defined sustainable development as development that meets the needs of the present without compromising the ability of future generations to meet their own needs. Sustainability has three dimensions i.e. social, environmental and economic. These dimensions need to be balanced so that sustainability is achieved. Overexploitation of resources, climate change, and scarcity of resources are some of the reasons necessary to understand sustainability. Sustainability is not only regarding the environment but as health care personnel we need to understand the importance of sustainability and how it affects the health of the individual and community as a whole. Health care practices need to be in tune with sustainable developments so that health for all is achieved. Sustainable practices, sustainable prevention, diagnosis and treatment, e practices and others are some of the approaches that need to be followed for sustainable healthcare practices. It is not easy to follow all these practices due to lack of political will, lack of resources, lack of expertise and high cost of implementing the sustainable measures. But as responsible citizens we need to work together as a team so that future generations will not suffer the consequences of the present generation’s action. Further research should be done to develop ways and means to identify the negative and positive contribution of health care sector to sustainable development.
EMERGING ASPECTS IN TARGETED DRUG DELIVERY SYSTEMS
Authors: Sahoo Dr. Chinmaya Keshari , Pattajoshi Sidheswar Prasad , Moharana Alok Kumar , Bhanja Dr. Satyabrata
Published: June 2024

In terms of a targeted medicine delivery system, Paul Ehrlich's "magic bullet" idea is a method that specifies the drug moiety straight into its specified bodily location. The Targeted Drug Delivery System (TDDS) is a cutting-edge method for pharmaceutical science innovation. Instead of delivering the drug to the entire body, it targets a specific cell, tissue, or organ through a carrier to achieve therapeutic effectiveness. It has created a number of cutting-edge techniques to treat fatal or chronic diseases in the body by delivering the drug to the right places for longer duration in the body. To solve the issues with traditional drug delivery methods, TDDS is required. There are various carrier systems being utilized and researched.
VARIATION IN THE PLANKTON ABUNDANCE IN THE RAIN WATER
Authors: Khanduri Dr. Vandana
Published: June 2024

Microorganisms were studied in the premises of Guru Nanak Vidyalaya in rainwater during the rainy season. We found many microorganisms in the rainwater collected. Plankton are a collection of tiny organisms that live in a water, for eg.pond, river etc. It is a free floting organisms, it includes plant and animal that float along at the mercy of the sea's tides and currents. It comes from the Greek meaning "drifter" or "wanderer." There are two types of plankton, free floting plants-called phytoplankton, and weak-swimming animals--called zooplankton.
ADDRESSING CRISPR/CAS9 CHALLENGES IN AUTISM GENE EDITING: NAVIGATING OFF-TARGET EFFECTS, IMMUNOGENICITY, AND APOPTOSIS
Authors: Rekha G. Sai Sri , Chandana B. Mani , Manogna K. Sai , Raju B. Deva Prasad , Rajani N. , Sushma N. John
Published: June 2024

Autism spectrum disorder is an array of neurodevelopmental disorders with wide range of phenotypic and genetic diversity. Autism is a complex, behaviourally well-defined syndrome associated with pleotropic genes. Majority of neuropsychiatric disorders are characterized by cognitive and social impairments with restricted and stereotypic patterns of eyes, fingers and toes. The neuro atypical disorders present on the wide spectrum of autism are believed to have strong genetic contribution with high heterogeneity, complicating the discovery of complete aetiology involved in ASD. A multitude of risk factors associate with the severity of autism that may develop into irreversible, lifelong neurological syndrome suggesting the importance of premature prediction and treatment of ASD. The early onset diagnosis of behavioural phenotype in children will greatly progress the research on genetics and neuroscience to guide the discovery of precise medicine for the treatment of ASD. Currently, CRISPR/CAS9 is the most efficient and genetic engineering technique for correcting disease specific mutations with wider clinical applications. It is a promising gene editing tool to develop in vivo and in vitro models that mimics the human phenotype with fewer off targets effects. CRISPR/CAS9 is applied in the clinical research domain to promote the discovery of target therapeutics and treatment against ASD.
PRODUCTION OF FOOD GRADE PIGMENTS FROM MICROBIAL SOURCES
Authors: Periyasamy Tamilarasi S , Chandrasekar Ajay Kasivishwanathan , Lakshmanan Hariprasath
Published: June 2024

For long time, the utilization of manufactured synthetic colorants has been highly questionable because of its negative evaluation. The best substitute for this would be the natural food colorants from sources such as plants, animals and microorganism’s, which have much positive health benefits. For biotechnological production of colorants when compared with other sources, microorganisms are more suitable due to ease of availability, rapid culturing and more probability of genetic manipulation. Food-grade colours like quinones, carotenoids, microorganisms produce flavins, melanins and more precisely monascins, violacein, indigo, etc. The food industry's output of components obtained from fermentation is growing steadily each year, but manufacture of food-grade pigments from microbial sources is still in developmental stage. To name a few, Monascus pigments, βeta carotene from Blakeslea trispora, Riboflavin from Ashbya gossypii, Phaffia rhodozyma, Arpink red from Penicillium oxalicum, Astaxanthin from Xanthophyllomyces dendrorhous, lycopene from Erwinia uredovora and Fusarium sporotrichioides. Additionally, some bacteria, including Serratia sp. and Streptomyces sp., create large quantities of carotenoids.. Numerous factors such as pH, temperature, carbon sources, minerals, nitrogen sources, moisture content, types of fermentation and aeration rate can affect the production of food grade pigments effectively. Aside from the optimal production strategies of the food grade pigments, they got lots of health benefits like can act as antibiotics, antioxidant activity, anticancer agents, anti-proliferative effects and immune-modulators. So natural bio-colorant like food grade pigments from microbial sources has great demand and still more research probability can be expanded to develop more bio-products.
ADVANCED BIOPROCESSING METHODS: ENHANCING PRODUCTION, PROCESSING, AND ISOLATION OF MICROBIAL PRODUCTS
Authors: Bala Kiran , Verma Sakshi , Dogra Arushi , Singh Raj Kumar Anjana , Lata Pushp
Published: June 2024

The bioprocess technique involves creating useful products using whole microorganisms, living cells, or components of living organisms through a series of processes such as upstream, fermentation, and downstream processing. This technique improves the connection between biological systems and scientific and industrial fields.Bioprocessing techniques play a significant role in modern biotechnology, revolutionizing industries such as pharmaceuticals, food production, and biofuels. This chapter explores the fundamentals of bioprocessing, delving into microbial fermentation, cell culture techniques, downstream processing, recent advancements, and real-world case studies. Readers will gain insights into the multifaceted world of bioprocessing.
CURRENT STATUS AND FUTURE PROSPECTS OF GENETICALLY MODIFIED CROP PLANTS IN INDIA
Authors: Kumari Esha , Kumari Sneha , Das Sai Santosh , Panigrahi Laxmi Kanta
Published: June 2024

By introducing advantageous foreign genes or blocking the expression of endogenous gene(s) in agricultural plants, genetic engineering and plant transformation have dramatically enhanced harvests. Herbicide tolerance, insect resistance, abiotic stress tolerance, disease resistance, and nutritional enhancement are all positive features that crops with genetic modification may have. 32 crops with more than 525 distinct transgenic events have been approved for production worldwide as of this writing. It has been demonstrated that transgenic technology increases agricultural yields, lowers pesticide and insecticide use, lowers CO2 emissions, and lowers the cost of food production. However, concerns about the toxicity and allergenicity of transgenic crops for humans as well as potential environmental issues like the likelihood of gene fling, negative effects on non-target animals, the rise of resistant weeds and insects, etc. prevent their widespread use. In response to these concerns, other techniques including cisgenesis, intragenesis, and most recently genome editing, have been used. Since some of these alternative methods may produce agricultural plants free of any foreign DNA, it is projected that these crops will likely be more popular with consumers than transgenic crops and will receive regulatory clearances more rapidly. The most recent approaches and instruments developed to address some of these issues and give a full update on the genetically modified (GM) crops that have been grown. The issues with the extensive usage of GM (genetically modified) crops are also briefly discussed.
SOURCES OF BIOENERGY AND THEIR PRACTICALITY IN THE MODERN WORLD
Authors: Shanthi Natarajan , Murugesan Subbiah , Shanmugasundram Shyamala Gowri , Mani Pillathil Jegan Pillathil Senthil
Published: June 2024

Bioenergy is one of many various alternatives accessible to assist in meeting our energy requirement. It is a renewable energy source obtained from organic molecules. Wood, agricultural products, and organic waste are examples of these materials. Currently, there is an increase in energy demand, and biodiesel production appears to be a very attractive developing sector for various reasons: it is highly biodegradable and has low toxicity, and it can replace diesel fuel in a variety of uses. As a result, there has been a surge in interest in bioenergy in recent years, this would allow for the development of a sustainable bioenergy sector. Increased production of these fuels is projected to benefit the world economy and aid in the mitigation of climate change.
ENVIRONMENT FRIENDLY RENEWABLE ALGAE BIOFUEL PRODUCTION AND ITS FUTURE PROSPECTS
Authors: Shanthi Natarajan , Murugesan Kotteswari , Mani Pillathil Jegan Pillathil Senthil , Murugan Selvakumar , Allasamy Pasupathy , Murugesan Subbiah
Published: June 2024

Biomass has gained popularity in recent years due to its capacity to generate renewable electricity, green energy, biofuels, and thermal energy. Algae, which are a sort of living biomass, are the most frequent type of biomass. They absorb carbon dioxide as they grow and expel it when used for energy. Because of the carbon cycle, many people believe biomass to be a carbon-neutral source of energy. As a result, algae are the ideal contender for biodiesel production since it can minimize greenhouse gas (CO2) emissions while providing more fuel than other bio-oil sources that require less fresh water and fertile land. Lowering greenhouse gas emissions means less environmental effect from climate change and global warming. Adequate biomass resources and a well-functioning biomass market that can ensure stable, sustainable, and long-term biomass supplies are critical prerequisites for achieving such goals. Various countries have extensive experience with developing biomass markets and connecting available resources with market demand.
NANOTECHNOLOGY AN APPROACH IN “ENVIRONMENTAL REMEDIATION”
Authors: Bepari Varnita , Purena Dr. Rupal
Published: June 2024

Nanotechnology is widely used in many forms. The recent advancement in nanotechnology is its use in environmental remediation. Different types of pollutant are causing harm to environment and to minimize them nanoremediation can be done using variety of metal, carbon, polymer, silica based. This chapter deals with the major source of environmental pollution and their cure through the route of nanotechnology.
REVIEW STUDY THE PHYSICOCHEMICAL PROPERTIES OF IONIC LIQUIDS AND ITS TREMENDOUS SIGNIFICANT
Authors: Barman Benvikram , Banjare Manoj Kumar
Published: June 2024

An ionic liquid is a salt that has a melting point lower than the boiling point of water. Other names for ionic liquids include molten salts, designer solvents, neoteric solvents, and ionic fluids. Ionic liquids are mostly composed of inorganic anions and organic cations. This review looks at the many physicochemical properties of ionic liquids as well as some of their key features. The physicochemical characteristics and importance of ionic liquids are the main topics of this review
Assessment of Hyperglycemic Potentials of Khaya Anthotheca Stem-Bark Extracts on Alloxan-Induced Diabetic Rats
Authors: Umaru Kerenhappuch Isaac , Nanmar Chakfa , Umaru Isaac John , Ugoeze Ezeonu Stephen , Tensaba Akafa Andes , David Bando Christopher
Published: June 2024

Introduction: Medicinal plants have been the basis of treatment of various diseases in African traditional medicine as well as other forms of treatment from diverse cultures of the world. Khaya anthotheca is a member of the family Meliaceae, a native to Africa. It is a medicinal plant widely used for several therapeutic purposes. Herein, phytochemical study, hyperglycaemic investigations was carried out on the methanol extract of Khaya anthotheca Stem-bark. Materials and Methods: However, 35 rats were distributed into seven groups to evaluate the anti-diabetic activity of K. anthotheca stem-bark methanol extract at the dosage range of 50-400 mg/kg/b.wt. The analysis was done using the software-SPSS one-way ANOVA at a significance level p<0.05. Results: The result of the anti-diabetic study reveals that extract elicited substantial (p<0.05) inhibition of hyperglycaemic. The plant Khaya anthotheca stem-bark methanol extract displayed profound (p<0.05) anti-hyperglycaemic action at the dosage of 200 mg/kg/b.wt, 300 mg/kg/b.wt. and 500 mg/kg/b.wt. against induced diabetic rats. Conclusion: This study therefore suggests the use of Khaya anthotheca as a hypoglycaemic agent and for treatment of diabetic. Further studies are needed to discover the bioactive constituent of the plant responsible for this anti-diabetic activity.
Implementasi Model Pembelajaran Berbasis Proyek dalam Meningkatkan Keterampilan Berfikir Siswa
Authors: Fazillah Oryn , Nisa Sahrun
Published: June 2024

This research aims to find out how the implementation of a project-based learning model can improve students' thinking skills. The use of a project-based learning model is an effective way to develop critical, analytical and creative thinking skills in students. In this model, students are given project assignments that must be completed in groups by following scientific stages starting from formulating problems, designing problem solutions, implementing plans, to presenting the final results. Through the process of completing the project, students are trained to identify problems, collect and analyze data, formulate hypotheses, plan experiments, draw conclusions, and communicate results. Direct student involvement in each stage will encourage them to think critically, creatively and analytically in solving real problems. This research uses qualitative methods with observation, interview and document study techniques to collect data. The research results show that the implementation of a project-based learning model can improve students' thinking skills significantly. Students become more active, enthusiastic and motivated in the learning process, and are able to develop the higher order thinking skills needed in the 21st century.
Efektivitas Expressive Writing terhadap Penurunan Tingkat Kecemasan pada Mahasiswa Psikologi Angkatan 2022 Kelas K Universitas Negeri Padang
Authors: Rahmayati Septi , Nusaibah Tsabitha , Ramadhani Annisa , Zikra Muhammad Al , Adhani Reihan Lutviansyah , Aulia Prima
Published: June 2024

The research was conducted to see if expressive writing techniques are effective for reducing anxiety. And also can overcome excessive anxiety that exists in individuals. Data collection is carried out using expressive writing techniques during the technique process. This research is a quasi-experiment in the form of a one group pre test, post test design. The expressive writing technique was carried out for four days with 5 research subjects who were psychology students of class 2022, class K, Padang State University. The subjects were measured using a pre test, then given treatment, then given a post test to see if this expressive writing technique is effective for students who experience anxiety. The data obtained were then analyzed using a paired sample t-test with the results obtained a significance value of 0.000 < Cronbach's alpha (0.05). It can be seen that the results of the study show that the expressive writing technique is said to be effective for reducing the anxiety of psychology students class 2022 class K State University of Padang. Research participants also know how to overcome anxiety in the future if anxiety arises. Participants in this study can also perform expressive writing techniques independently. based on the results of this study, it is recommended that subjects can convey their opinions to provide advice to researchers about input that should be used as lessons for researchers.
Tortum Çayı Havzası Agroturizm Potansiyelinin Değerlendirilmesi
Authors: Şanlı Dilara , Koday Zeki
Published: June 2024

Agroturizm şehir yaşantısından uzaklaşmak isteyen insanlar tarafından, kırsal alanlarda, köy evlerinde veya çiftliklerde konaklayarak, tarımsal faaliyetlere katılarak, yöresel ürünleri tüketerek ve farklı kültürlerle etkileşime geçerek gerçekleştirilen bir seyahat biçimidir. Agroturizm sayesinde ziyaretçiler gönüllü olarak çiftliklerde çalışmaktadır. Agroturizm hem çiftliklere ek gelir sağlamakta hem de sürdürülebilir bir turizm anlayışı oluşturmaktadır. Tortum Çayı Havzası, Doğu Anadolu Bölgesi ile Karadeniz Bölgesi arasında kalmakta ve tarıma elverişli araziler bulunmaktadır. Ayrıca zengin kültürel miras ve turizm potansiyeline sahiptir. Bu doğrultuda havzanın agroturizm bakımından da değerlendirilmesi gerektiği düşünülmektedir.
Yapılan bu çalışmada Tortum Çayı Havzası’nda bulunan agroturizm çiftlikleri incelenmiştir. Havzada arazi gözlemleri yapılarak agroturizm potansiyeli açısından öneriler sunulmuştur. Araştırma sahasında yapılan mülakatlar ve arazideki gözlemler sonucunda elde edilen bulgularla SWOT analizi yapılmıştır. Yapılan bu analizler neticesinde gerçekleştirilen görüşmeler, incelenen ikincil kaynaklar ve toplanan veriler bir araya getirilerek havzanın agroturizm açısından güçlü ve zayıf yönleri ile fırsatlar ve tehditler tespit edilerek SWOT analizi yöntemiyle açıklanmıştır.
Azerbaycan Fındık Üretiminde Gah Rayonu’nun Yeri
Authors: Çetinkaya Sabina
Published: June 2024

Ana yurdu Anadolu ve özellikle de Doğu Karadeniz kıyıları olan fındığın önemli üretim alanlarından biri de Kafkaslardır. Kafkas ülkelerinden Azerbaycan ve Gürcistan ise dünya fındık üretimi sıralamasında genellikle ilk onda yer almaktadır. Özellikle, Azerbaycan’da fındık tarımı son yıllarda hızla gelişmektedir. Gah Rayonu, Azerbaycan’ın en çok fındık üretiminin yapıldığı Şeki-Zagatala Bölgesi’nde bulunan altı rayondan biridir. Tarım ve hayvancılık rayonu olan Gah’ta önemli ekonomik faaliyetlerden biri de meyveciliktir. Tarımsal faaliyetler ve üretimin fiziki ve beşeri coğrafi koşullara bağlı olarak şekillendiği bilinmektedir. Azerbaycan’ın kuzey batısında bulunan Gah Rayonu fındık yetiştiriciliği için uygun iklim ve toprak koşullarına sahiptir. Özellikle Gah Rayonu’nun kuzey kesimindeki orta ve yüksek dağlık arazilerde görülen nemli ılıman iklim burada tarih boyu fındık yetiştiriciliğinin gelişmesi için olanak sağlamıştır. Ayrıca, fındık ağaçları bu bölgedeki ormanlarda yabani şekilde de yetişmektedir. Fındık yetiştiriciliği daha çok rayonun kuzey kesimlerinde ve Eğriçay Vadisi’nde gelişmiştir. Bu araştırmada Gah Rayonu’nun en önemli ekonomik faaliyeti olan fındık yetiştiriciliği, rayonun coğrafi koşulları dikkate alınarak araştırılmıştır. Çalışmada karma araştırma yöntemi kullanılarak hem nitel hem de nicel veriler toplanmış ve analiz edilmiştir. Gah Rayonu’nun Azerbaycan’ın fındık üretimindeki rolü ile ilgili değerlendirme yapılmış, Azerbaycan Devlet İstatistik Komitesi’nden elde edilmiş nicel veriler betimsel istatistik tekniği kullanılarak yorumlanmıştır. Araştırma sahasının haritaları ArcGIS 10.5 programında çizilmiştir.
Ülke ekonomisine katma değer ve istihdam sağlayan fındık yetiştiriciliği, desteklenmesi gereken bir ekonomik faaliyettir. Fındık bu bölgede yaşayanlar için önemli bir gelir kaynağı olduğu için fındık yetiştiriciliğinin Gah Rayonu’nun ekonomisindeki payı büyüktür. Rayondaki fındık üretiminde yıllar içinde gözlenen dalgalanmaların nedenleri araştırılmış ve gerekli önerilerde bulunulmuştur.
The role of Intrinsic Motivation On Innovative Work Behavior Mediated By Creative Self-Efficacy
Authors: Herbiyanti Febi , Rahmawati Indah , Ayu Hardjowikarto Dharliana
Published: June 2024

This study aims to examine the role of Intellectual Motivation on Innovative Work Behavior through Creative Self-Efficacy mediation in rattan craftsmen in Tegalwangi Village. In this study using a type of quantitative research method. This study examines and analyzes the role of creative self-efficacy as an intervening variable in intrinsic motivation and its effect on innovative work behavior. With a total sample of 103 rattan craftsmen in Tegalwangi Village. Data collection techniques include questionnaires, interviews, and observations. The measurement scale used in this study is using a Likert scale of 1 to 5 with categories strongly disagree, disagree, neutral, agree, and strongly agree. The analysis technique in this study is SEM (Stuctural Equation Modeling) with PLS (Partial Least Square) Program version 4. The results showed a significant influence of intrinsic motivation on creative self-efficacy, creative self-efficacy on innovative work behavior, intrinsic motivation on innovative work behavior, and creative self-efficacy partially mediated between intrinsic motivation and innovative work behavior in rattan craftsmen in Tegalwangi Village.