bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunohistochemical analysis of cathepsin-D in benign and malignant salivary gland neoplasms. Evaluation of its role as a prognostic indicator
Authors: Mohan Mridula , Suresh Rakesh , Janardhanan Mahija , Savithri Vindhya , Aravind Thara
Published: April 2023

Background:

Salivary gland tumors are histologically the most heterogeneous group of tumors. Traditional diagnostics and grading of these tumors often fail to provide any insight into patient's clinical course. Cathepsin-D is a lysosomal acid protease secreted in increased levels in several malignancies. However, its role in salivary gland tumors has not been studied extensively. The present study aims to assess the expression of cathepsin-D in malignant and benign salivary gland tumors and to compare its expression in these tumors.

Materials and Methods:

A total of 40 salivary gland tumors which included 10 cases each of adenoid cystic carcinoma, mucoepidermoid carcinoma, pleomorphic adenoma and Warthin's tumor were evaluated immunohistochemically for cathepsin-D expression. Intergroup comparison of cathepsin-D expression was done between the benign and malignant groups using the Mann–Whitney U-test. Intragroup comparison was also done using Kruskal–Wallis test.

Results:

A statistically significant difference in the expression of cathepsin-D was observed between the benign and malignant groups. The malignant group showed a considerably higher cathepsin-D expression (mean value 6.284 ± 4.377) when compared to the benign group (mean value 2.281 ± 2.459). The differences in the immunopositivity between the malignant and benign groups were found to be highly significant (P = 0.004).

Conclusions:

Increased expression of cathepsin-D is observed in the malignant salivary gland neoplasms. This may prove to be a useful marker for the aggressive biologic behavior as well as invasive potential of salivary gland neoplasms.
Comparative evaluation of alteration in taste perception among Gutkha chewers with and without OSMF and healthy subjects
Authors: Harini T.C , Ila Anbu , Nagarajappa Anil Kumar , Chandran Ajay , Kolte Deepak R. , Gunturu Srikanth
Published: April 2023

Context and Aim:

The major afflictions such as odynophagia (painful swallowing) and trismus that occur in patients with oral submucous fibrosis (OSMF) are well documented, but the impairment of gustatory functions has not received much consideration in the past. The present study was planned with a similar intent to assess and compare the alteration in taste perception among gutkha chewers with and without OSMF and healthy subjects.

Materials and Methods:

The present study was designed as a prospective case–control study comprising 90 individuals within an age range of 15–50 years who were divided into three groups with Group A consisting of 30 patients who were gutkha chewers with OSMF, Group B consisting of 30 individuals who were gutkha chewers but without OSMF and Group C consisting of 30 healthy subjects who were included as normal controls. The taste intensity response scores for the four basic tastes were recorded and the results obtained were, then, subjected to statistical analysis.

Statistical Analysis Used:

The data were analyzed using SPSS version 16.0 (SPSS Inc., Chicago, IL, USA). Comparison of the said parameters was done using Chi-square test, analysis of variance and Tukey's post-hoc test. P < 0.05 was considered statistically significant.

Results:

The findings of the present study suggested that all taste sensations were affected more in Group A patients than the Group B and Group C individuals.

Conclusion:

The results obtained in the present study were found to be encouraging as it was demonstrated that taste perception varied significantly among the patients with OSMF as against those having habit of betel nut/gutkha chewing but those who did not develop OSMF and the normal healthy controls and this data, though, initial, might be used on a scientific basis to improve the quality of life in the affected patients as well as to prevent the further progression of the disease process.
Ameloblastomatous calcifying cystic odontogenic tumour involving the mandibular anterior region
Authors: Gade Lalitkumar P. , Jagtap Kiran S. , Lunawat Snehal D. , Choudhary Sneha H.
Published: April 2023

Ameloblastomatous calcifying odontogenic cyst (COC) is a very rare histopathological variant of COC, which is an odontogenic cyst of the jaw. The term “calcifying odontogenic cyst” is not covered in the World Health Organisation (WHO) Classification of Tumors 2005 and was re-named as calcifying cystic odontogenic tumour (CCOT). There are only a few reports containing details on CCOT being associated with ameloblastoma. This variant has been classified as ameloblastomatous CCOT (type 3) as per the WHO 2005 classification. In this article, we reported an exceptional case of ameloblastomatous CCOT in a 15-year-old boy involving the mandibular anterior region, which is a rare combination for age and site of the lesion, along with an impacted tooth which is again an uncommon association.
Inhibitory effect of garlic and omam extracts on Mucor circinelloides, a fungus causing mucormycosis
Authors: Nimoshini G , Nataraj Priyadharsini , Rameshkumar Annasamy , Krishnan Rajkumar , Savithri S.
Published: April 2023

Context:

Mucor circinelloides is reported to be the second among the most common causative agents of emerging mucormycosis. It is intrinsically resistant to most known antifungals. Further the use of antifungals cause side effects. Traditional knowledge system for treating various ailments is stronger in India and it also backs deriving various bioactive compounds from herbal sources, in the modern system of medicine. Therefore, two most commonly used culinary herbal materials viz., ginger and omam were studied in vitro against M. circinelloides, as an alternate to antifungal drugs.

Aims:

To explore the traditional herbal resources as alternate to Amphotericin B to use against M. circinelloides, a fungus causing mucormycosis.

Methods and Material:

Aqueous extracts of garlic and omam were prepared and tested against M. circinelloides, at different concentrations. A positive control with Amphotericin B and negative control without any supplements were also maintained. The inhibitory effect was assessed by adopting optical density (OD) measurement method in SD broth and SD Agar Well Plate using spore suspension as inoculum.

Statistical Analysis Used:

Paired student T test was employed using SPSS Version 1.6.

Results and Conclusions:

Both garlic and omam extracts were found to inhibit the M. circinelloides and their MICs were 600 and 700 μL/mL. It is comparable with the MIC of Amphotericin B, 200 μg/mL. Thus, the regular use of garlic and omam can reduce the risk of possible mucormycosis and these herbs can be explored for drug formulations against M. circinelloides.
Qualitative assessment of Aloe vera as natural tissue fixative
Authors: Narwal Anjali , Singh Esha , Duhan Jigyasa , Dhattarwal S. K. , Singh Virender , Kamboj Mala , Devi Anju , Gupta Shruti
Published: April 2023

Objectives:

The art of microscopy is only appreciable in well-fixed tissues. We conducted this study to determine the effectiveness of Aloe vera as a tissue fixative and compare its results with the natural fixatives already studied in the literature.

Materials and Methods:

A pilot study was tried out using commercially available fresh chicken and fish with Aloe vera, and then after getting the promising results similar study protocol was carried out using 10-autopsied human tissue. Four natural fixatives-30% jaggery solution, 20% honey solution, 20% sugar solution, 20% Aloe vera solution and 10% formalin were used for fixation in the study. Fixation of tissues was carried out at room temperature for 24 h. All pre- and postfixation measurements were recorded using stereomicroscope and its software. The difference between pre-and postfixation was calculated and later, all pieces were kept for routine tissue processing followed by routine staining. The tissue sections were assessed for quality, and the whole procedure was blinded among three oral pathologists who scored them.

Results:

The mean percentage of shrinkage in each bit with different reagents was calculated. The shrinkage seen with 10% formalin and 20% Aloe vera were more likely similar. Among all the natural fixatives, qualitatively also Aloe vera excelled and its results were comparable to that of formalin.

Conclusion:

The use of Aloe vera in the present study as fixative is the first of its kind, as exhaustive search of the literature shows only its use as transport media in dentistry.
Analysis of Inheritance patterns, gender dimorphism and their correlation in lip and palm prints – A cross-sectional study
Authors: Vanguru Raviteja , Pasupuleti Swetha , Manyam Ravikanth , Supriya Alapati Naga , Shrishail Birajdar Smita , Yoithapprabhunath Thuckanaickenpalayam Ragunathan
Published: April 2023

Background:

Forensic sciences deal with key areas to be included in judicial makeup that has been approved by both the court and the scientific community, which distinguishes truth from counterfeit. Lip and palmprints are one of a kind and do not change during the lifetime of a person unless any pathologies.

Objectives:

To evaluate the heritability, and gender dimorphism of lip and palm prints among parents and their offspring.

Methods:

A total of 280 participants were included in the study. Lip and palm prints were collected from participants using a digital camera. The photographic data obtained is subjected to Adobe Photoshop and analysed for inheritance. Gender dimorphism is evaluated by the predominant lip pattern and palm ridge count in four designated areas.

Results:

A positive resemblance of 28.4% was found between parents and offspring in lips, and for the right palm, it was 60.2% and 55.12% for the left palm (principal lines) which are statistically insignificant. In all six quadrants, the most predominant lip pattern found in males is type 5, and in females, type 11. The mean palm ridge density was significantly higher among females than males in all designated areas.

Conclusion:

The digital method of analysing lip and palm print images with Adobe Photoshop 7 software is a convenient method that allows for better visualisation and easier lip and palm print recording and identification. Considerable inheritance patterns and gender dimorphism were observed that aid in personal identification.
Systematic review and meta-analysis of the expression of p53 in the odontogenic lesions
Authors: Aldahash Fahdah
Published: April 2023

Odontogenic keratocyst (OKC) is an aggressive odontogenic lesion that has been the subject of continuous dispute about its biological activity and classification. 'Numerous studies are being conducted to see how much more or lower expression of the tumour-suppressing p53 protein is in the odontogenic cyst than in the dentigerous cyst (DC) or ameloblastic tumours. The aim was to find immunohistochemistry studies reporting on OKCs, DCs and ameloblastomas (AMBs); we searched MEDLINE, WEB of Science and SCOPUS. Effects may be shown to exist when the risk difference (RD) between lesions overexpressing and those without the p53 protein was a P value of less than 0.05. A total of 129 records were returned in the first hit. After the elimination of duplicates, there were 89 items, of which 18 were deemed eligible for inclusion. According to a meta-analysis of 13 studies including OKCs, DCs and AMB, the chance of p53 expression in OKCs is assessed to be 23 per cent higher (P = 0.003) than in DCs, whereas the probability is predicted to be 4 per cent lower (P = 0.028) than in AMBs. OKCs appear to act more like cancers than odontogenic sores as far as p53 articulation, and the order of this illness into the keratocystic odontogenic tumour (KCOT) ought to be rethought.
Salivary and serum acetaldehyde levels in betel quid chewers, pan masala chewers with or without tobacco and tobacco smokers
Authors: Pavithra Dorairaju , Dineshkumar Thayalan , Rajkumar Krishnan
Published: April 2023

Background:

Acetaldehyde, a natural by-product of combustion and photo-oxidation, has been detected at low levels in cigarette smoke. Various literature studies have shown increased salivary acetaldehyde production among smokers and heavy drinkers.

Aim:

The present investigation was performed to estimate the salivary and serum acetaldehyde levels in pan masala chewers (with or without tobacco), betel quid chewers and tobacco smokers.

Methodology:

Blood and Saliva samples were collected from 40 participants. The study participants were categorized into 4 groups of 10 individuals each. Subjects with no habits, betel quid chewing habit, pan masala chewing habit with or without tobacco and tobacco smoking habit. All the samples were centrifuged and subjected to gas chromatography (GC) analysis as per standard protocols provided by the manufacturer.

Results and Discussion:

No statistically significant difference in either serum or salivary acetaldehyde levels between Pan Masala chewers (with or without tobacco) and smokers was noted. However, higher mean serum and salivary acetaldehyde levels than the normal subjects and betel quid chewers was observed. It may be speculated that natural acetaldehyde, may not be released in estimated quantity of acetaldehyde by head space GC. Nevertheless, it is possible that addition of acetaldehyde as flavoring agents or preservatives for improving acceptability of the product can be a possible cause for these observations.

Conclusion:

Owing to various socio, economic and political reasons, implementation of the ban remains to be a formidable challenge. With these observations, we believe that absolute ban of all pan masala product is the ideal solution for minimizing the oral cancer burden in India.
HBE homozygous haemoglobinpathy – Fortuitous finding
Authors: Premika Sri V. L. , Sreeja C , Muthukumar R. Sathish , Nachiammai N. , Jayaraj Merlin , Harini Priya A. H.
Published: April 2023

A 24-year-old male patient presented with the principal complaint of deposits on his teeth and gingival pigmentation. After examination, he was diagnosed with chronic generalized gingivitis. He was further referred for pre-procedural routine blood investigations. Bleeding time, clotting time, and his random blood sugar values were normal. CBC report revealed the presence of erythrocytosis with microcytic hypochromic red blood cells. Following this peripheral smear was taken which reveals the presence of polychromatophils, target cells and a few spherocytes. Haemoglobin electrophoresis by high-performance liquid chromatography (HPLC) was performed which disclosed 90.8% of HbE, suggestive of homozygous haemoglobinopathy. He had no other associated systemic findings, and there was no relevant family history.

The patient was informed about his condition and stated to have pre-marital and pre-natal genetic counselling in the future. The patient being a carrier of the thalassaemic trait happened to know his condition incidentally, which could prevent future complications.
Evaluation of roots and root canals’ morphology of maxillary premolars in a Syrian subpopulation using cone-beam computed tomography
Authors: Allawi Safa , Madarati Ahmad A , Al-Tayyan Mouhammad
Published: April 2023

Introduction:

The morphology of the roots is variable and complex; hence, a better understanding of the root canal systems is important to provide optimal endodontic treatment. The aim of this study was to investigate the number of roots, and root canals’ morphology of the first and second premolars in the Syrian subpopulation, and their bilateral symmetry. In addition, it aimed at exploring the effect of gender on the morphological aspects.

Materials and Methods:

Two hundred and fifty cone-beam computed tomography (CBCT) images (140 images for females, 110 images for males) were collected and examined by two endodontists. Details of the number of roots, number of canals, and canals’ configurations in each root were recorded according to Vertucci classification by inspecting the CBCT images in all levels (axial, coronal, sagittal, oblique, and three dimensional). The Chi-square statistical analysis was performed to compare the canals’ morphologies and bilateral symmetry in both genders.

Results:

While most of the first premolars had two roots (59.2%), the majority of second premolars (80.8%) had one root. The highest proportions within the first and second premolars (41.8 and 36.1%) had Vertucci Type-II configuration. The ratios symmetry of maxillary first and second premolars for the number of roots were 90.4% and 93.6%, respectively, and for the number of canals were 94.4% and 90.4%, respectively. There was no significant difference in the proportion of symmetry for both genders in the first and second premolars regarding the number of roots and the number of canals (P > 0.05).

Conclusions:

While most maxillary first premolars were two-rooted with two root canals, maxillary second premolars tended to be single-rooted with two root canals; males had a greater number of roots than females. While maxillary second premolars exhibited greater bilateral symmetry in the number of roots than maxillary first premolars, the latter exhibited greater bilateral symmetry than maxillary second premolars in the number of root canals.
Evaluation of pH and dimensional stability of mineral trioxide aggregate and biodentine with and without triple antibiotic medicament: An in vitro study
Authors: Halkai Rahul S. , Ishaq. S Syed , Halkai Kiran R. , Zakaullah Syed , Diwanji Pavan R. , Mahveen Syeda Uzma , Algahtani Fahda Nabeel , Almohareb Rahaf
Published: April 2023

Introduction:

Calcium silicate-based cements has been shown to have improved antibacterial properties when incorporated into the triple antibiotic paste (TAP). However, the new material combination must withstand the tissue environment and be dimensionally stable when employed for endodontic applications. Therefore, this study aims to determine the pH and dimensional stability of mineral trioxide aggregate (MTA) and Biodentine incorporated with TAP.

Materials and Methods:

A total of 80 cylindrical discs of 6 mm × 3 mm dimensions (n = 20) were prepared with MTA, MTA + TAP (1:1), Biodentine, and Biodentine + TAP (1:1) in Groups 1, 2, 3, and 4, respectively. Each group’s specimens had half of their samples tested for dimensional stability (n = 10) and pH (n = 10). Samples were submerged for 1 min in containers containing 10 ml of distilled water and the initial pH was recorded and after the 7th day using a digital pH meter. To evaluate the dimensional stability, the samples were wrapped in wet gauze and kept at 37°C in the incubator for 24 h. Then, their initial lengths were measured, and were stored in distilled water at 37°C for a month before being measured once more with digital calipers. The data were statistically analyzed using one-way ANOVA, post hoc Tukey, and a paired Student “t” test (P ≤ 0.05).

Results:

MTA and Biodentine without TAP demonstrated a higher pH than with TAP; nonetheless, at both time points, all groups had an alkaline pH. With the exception of MTA + TAP, all the groups were dimensionally stable at both time intervals, but no significant difference was identified between the groups (P ≤ 0.05).

Conclusion:

Both MTA and Biodentine combined with TAP exhibited alkaline pH throughout the study period; however, Biodentine combined with TAP was dimensionally more stable compared to MTA with TAP.
COVID-19-Associated Severe Autoimmune Hemolytic Anemia
Authors: Nair Lakshmi J. , Regukumar Aravind , Baalamurugan K. T.
Published: April 2023

Autoimmune hemolytic anemia (AIHA) is a very rare presentation of COVID-19, and AIHA due to COVID-19 alone (i.e., in the absence of an associated underlying disorder) is extremely rare. Warm agglutinin disease accounts for the majority of AIHA in general. Here, we report a case of a 23-year-old male with bronchial asthma who was referred to our hospital with SARS-COV-2 infection and severe anemia presenting as acute immune-mediated hemolytic crisis due to warm autoimmune hemolytic anemia (AIHA). Extensive laboratory testing was performed, including polyspecific direct antiglobulin test, complete autoimmune workup and common infections leading to AIHA were ruled out by serology and molecular methods. The patient required multiple blood transfusions and other therapeutic interventions before clinical stabilization. Treatment of new-onset AIHA is always challenging in the presence of an active viral replication; combining immunosuppression with active COVID-19 infection creates extremely difficult diagnostic and management settings, as this case illustrates.
Microleakage and Bacterial Adhesion with Three Restorative Materials Used to Seal Screw-access Channels of Implant Abutments
Authors: AlQarawi Firas Khalid , AlShammasi Baneen Mansour , AlBasry Zainab Ahmed , AlAwami Heba Zaki , AlEraky Doaa Mostafa , AlJindan Reem Yussuf , Alrumaih Hamad Saleh , Alshahrani Faris Abdullah
Published: April 2023

Background:

Proper sealing of screw-access channels against microbial microleakage is advisable for the long-term success of screw-retained implant prosthesis.

Objective:

This study aimed to compare the bacterial adhesion and microleakage with three restorative materials, namely, composite resin, acrylic resin and bis-acryl, that are used to cover the access channels of screw-retained implant prostheses, using polytetrafluoroethylene tape as a spacer material.

Materials and Methods:

In this in vitro study, 18 titanium straight abutments (Hex-lock® Zimmer) were torqued into implant analogs, which were then subdivided into three groups. The samples of each group were filled with polytetrafluoroethylene tape and sealed with the three restorative materials (Group A: composite resin; Group B: acrylic resin; Group C: bis-acryl). Measurements of surface bacterial adhesion and internal microleakage were then recorded. The results were statistically analyzed using Kruskal–Wallis and Chi-square tests.

Results:

No significant difference was found between the investigated materials in terms of their sealing effectiveness against microbial microleakage (P = 0.06). Regarding bacterial adhesion, composite resin showed the highest number of surface adhesion, but there was no significant difference between the three materials (P = 0.081).

Conclusion:

The results of this study suggest that composite resin, acrylic resin and bis-acryl materials could be used alternatively in sealing the implant access channel owing to no significant differences in terms of microleakage and bacterial adhesion.
Antibiotic Resistance Pattern of Acinetobacter baumannii Strains
Authors: Sannathimmappa Mohan B. , Nambiar Vinod , Aravindakshan Rajeev
Published: April 2023

Background:

Multidrug-resistant (MDR) Acinetobacter baumannii is of serious health concern and associated with high mortality. Data regarding the antibiotic resistance pattern of A. baumannii strains in Oman is limited.

Objectives:

To determine the antibiotic resistance pattern of A. baumannii from various clinical samples in a tertiary care hospital in the North-Batinah region of Oman.

Methods:

A. baumannii isolates recovered from various clinical samples in the Microbiology laboratory of Sohar Hospital, Oman, during 2015–2019 were retrospectively analyzed. Organism identification and their antibiotic resistance patterns were performed as recommended by the Clinical and Laboratory Standards Institute.

Results:

A total of 1890 A. baumannii nonduplicate isolates were found from clinical samples of 1326 patients. The isolates were more frequently isolated from elderly patients (40%) and in-patient department patients (67%). Infection/colonization was more common among patients treated in the medicine, intensive-care unit, and surgery departments. A. baumannii strains were highly resistant (50-83%) to most of the tested antibiotics, with the highest against ceftriaxone (83%) and ceftazidime (75%), and lowest against colistin (1%) and tigecycline (8%). Among the isolates, 67% (1265) were MDR strains. Of these, 22%, 32% and 16% were resistant to all six, five and four classes of the tested antibiotics.

Conclusion:

The study found that the frequency of isolation of MDR A. baumannii isolates in the northern region of Oman is high.
Pharmacist-Driven Geriatric Medication Assessment at an Acute Care Teaching Hospital
Authors: Steele Abigail J. , Berletic Josef D. , Gionfriddo Michael R.
Published: April 2023

Older patients are often prescribed many medications and are at higher risk for medication-related problems. Pharmacists can help to identify potentially inappropriate medication use that may precipitate adverse drug events resulting in mental status changes, falls, and hospitalization.
A Pharmacist-Driven Geriatric Medication Assessment program was established by clinical pharmacists to evaluate medication use in older patients admitted to a pilot unit of an acute care hospital as part of an Age-Friendly Care initiative. This article describes the implementation of this
program and the types of medication interventions pursued by the pharmacists. Pharmacist recommendation acceptance rate by the health care team was greater than 90% overall for medication reconciliation, potentially inappropriate medications, and other medication interventions.
$q$-opers, $QQ$-systems, and Bethe Ansatz
Authors: Frenkel Edward , Koroteev Peter , Sage Daniel , Zeitlin Anton M.
Published: April 2023

We introduce the notions of

(G,q)

-opers and Miura

(G,q)

-opers, where

G

is a simply connected simple complex Lie group, and prove some general results about their structure. We then establish a one-to-one correspondence between the set of

(G,q)

-opers of a certain kind and the set of nondegenerate solutions of a system of Bethe Ansatz equations. This may be viewed as a

q

DE/IM correspondence between the spectra of a quantum integrable model (IM) and classical geometric objects (

q

-differential equations). If

\mathfrak{g}

is simply laced, the Bethe Ansatz equations we obtain coincide with the equations that appear in the quantum integrable model of XXZ-type associated to the quantum affine algebra

U_q \widehat{\mathfrak{g}}

. However, if

\mathfrak{g}

is non-simply-laced, then these equations correspond to a different integrable model, associated to

U_q {}^L\widehat{\mathfrak{g}}

where

^L\widehat {\mathfrak{g}}

is the Langlands dual (twisted) affine algebra. A key element in this

q

DE/IM correspondence is the

QQ

-system that has appeared previously in the study of the ODE/IM correspondence and the Grothendieck ring of the category

\mathcal{O}

of the relevant quantum affine algebra.
THE EFFECT OF NOZZLE DIAMETER AND LAYER THICKNESS ON MECHANICAL BEHAVİOUR OF 3D PRINTED PLA LATTICE STRUCTURES UNDER QUASI-STATIC LOADING
Authors: DEMİRCİ Emre , ŞENAYSOY Safa , TUĞCU Salih Emre
Published: April 2023

Lattice structures are widely preferred because they have good properties such as lightness, high energy absorption capacity and strength. Moreover, these lattice structures can be produced by utilizing 3D printer. Therefore, this study aimed to investigate the effect of the mechanical behavior of the different printing parameters on the lattice structures. Firstly, FBCC and FBCCZ lattice structures were printed with various printing parameters such as nozzle diameter of 0.25 mm-0.4 mm and layer thickness of 0.1 mm–0.15 mm. Then, quasi-static compression tests were carried out to determine the mechanical behavior of lattice structures. Force-displacement behavior, equivalent elastic modulus and energy absorption capabilities of lattice structures printed with different parameters were calculated from the results of quasi-static compression test. According to the results, it was observed that the mechanical behavior was significantly affected when the nozzle diameter and layer thickness were changed. It was determined that the strength and energy absorption of the structures printed with a nozzle diameter of 0.25 mm and a layer thickness of 1.5 mm were decreased. In addition, it was observed that the effect of the printing parameters on the mechanical behavior can be different according to the lattice type and lattice rod diameter.
Afectación del derecho a la indemnidad sexual en delitos de actos contra el pudor. Análisis de procesos judiciales en Tarapoto
Authors: Silva Huamantumba Grethel , Huamantumba Palomino Marina Victoria , Córdova Calle Elia Anacely , Silva Huamantumba Edman Junior , Chávez Quesquén Walther Fructuoso
Published: April 2023

La presente investigación científica se realizó con el objetivo de analizar la afectación del derecho a la indemnidad sexual en delitos de actos contra el pudor Análisis de procesos judiciales en Tarapoto. Se basó en la problemática en el distrito de Tarapoto, el ente propio para conocer los delitos de actos contra el pudor es el 2° Juzgado Unipersonal Penal de Tarapoto, todo ello con el fin de identificar la incidencia de la afectación del derecho a la indemnidad sexual en los delitos de actos contra el pudor a menores de edad. La investigación fue básica, de enfoque cualitativo y diseño no experimental, descriptiva; usó la teoría fundamentada y entrevistas como técnicas, y la guía teórica, con la guía de entrevistas como instrumentos; la población prevista fueron los procesos judiciales desarrollados en el Segundo Juzgado Unipersonal Penal, así como al magistrado y la Casación 790-2018-San Martín. Las técnicas de investigación empleadas fueron el análisis de registro documental y entrevista con expertos como guía de análisis de documentos y guía de preguntas. Se concluye que las consecuencias legales al evidenciar la afectación del derecho a la indemnidad sexual, es media. Razón que, por ser delitos de naturaleza clandestinos, donde la única explicación de la baja menor por estas infracciones debe estar sustentada con componentes marginales que puedan conectar lo explorado con la manifestación criminal que interfiere en el libre desarrollo de la personalidad, integridad física, psicológica.
Patch Repair for Intestinal Perforation Closure in an Ex-Vivo Porcine Model with Burst Pressure Characterization
Authors: Wheeler Matthew B
Published: April 2023

Background: Bowel perforation is the loss of intestinal wall integrity and can occur by several mechanisms including infection, obstruction, inflammation, trauma and iatrogenic causes. Incidences of bowel perforation range from 1-7% in pediatric trauma patients and 0.02-8% in adults. There is no specific classification for gastrointestinal perforations, but several methods have been used to describe perforations based on etiology, including systemic, inflammatory, medication, neoplastic and instrumentation-induced perforations. We assessed the feasibility of closing small intestine perforations with a mesh patch instead of sutures only.

Methods and Findings: Nine porcine ex-vivo small intestine specimens were incised 0.5 cm to simulate bowel perforations. Control group perforations were sutured closed without mesh. The two experimental groups were closed by mesh sewn to the outside (first group) or inside (second group) of the bowel wall. Each specimen was submerged in normal saline and insufflated until air bubbles leaked from the perforation. That insufflation pressure was recorded as the burst pressure. The control group burst at 78.0±17.9 mmHg. The “patch outside” group burst at 54.7±9.1 mmHg. The “patch inside” group burst at 32.0 ±4.6 mmHg. Only the “patch inside” group had statistically significant inferiority, but both groups trended towards inferiority.

Conclusions: Preliminary research indicates that patch repair of intestinal perforations is likely inferior to sutures alone, although repair with the patch outside the bowel wall cannot be completely excluded because of the high variability of the data. Further research may try alternate patch types or different variations to find a non-inferior closure method. A sample size of n=9 each would give 80% power to detect a minimal detectable difference of 20 mmHg.
Numerous Types of Stem Cells Possess Potential to Treat Congenital Hydrocephalus
Authors: Gallicchio Vincent S
Published: April 2023

Twenty-five percent of premature neonate’s experience Intraventricular Hemorrhage (IVH) and 10% of these events are complicated further by the occurrence of hydrocephalus. The number of infants at high risk for IVH and therefore Post Hemorrhagic Hydrocephalus (PHH), is rising due to improved survival rate of premature infants. Fetal onset hydrocephalus is a heterogeneous brain disorder involving Cerebrospinal Fluid (CSF) dynamics and is a result of both genetic and environmental factors. Mesenchymal stem cells present themselves as a potent therapeutic modality for brain injury based on their multipotency, anti-inflammatory, antioxidant and angiogenic functions. Numerous animal model clinical provide evidence that Mesenchymal Stem Cells (MSCs) can target nearly all mechanisms involved in the pathogenesis of hydrocephalus. Unrestricted somatic stem cells possess anti-inflammatory and immunomodulatory properties as well as release growth factors and cytokines with known neuroprotective and axonal growth promoting functions. Neural stem cells are self-sustaining, pluripotent cells that have the capability to correct brain maldevelopment, reduce brain damage, promote regeneration and repair via neurotrophic and immunomodulatory mechanisms and direct cell replacement. For these reasons, stem cells possess the potential to be an effective therapy and should be further researched.
Central Shunting for Tetralogy of Fallot After Original Blalock-Taussig Shunt in a 34-Year-Old Woman
Authors: Nakanishi Keisuke
Published: April 2023

The Blalock-Taussig (BT) shunt was first used to treat the tetralogy of Fallot in 1946. Since then, it has undergone improvements to create a short circuit in the pulmonary artery using an artificial blood vessel. The prognosis after palliative surgery alone is poor; hence, there is a need for radical surgery to improve the long-term prognosis. However, for various reasons, some patients have undergone the Blalock surgery alone without any other therapeutic interventions. In this report, we describe a case of a central shunt surgery performed to improve cyanosis in a patient who had been followed up for a long time without radical surgery after receiving an original BT shunt.
MANAGEMENT OF NITROGEN STRESS IN COTTON (Gossypium hirsutum L.) USING GREENSEEKER TECHNOLOGY
Authors: KARATAS Medine , Karademir Emine
Published: April 2023

This study was performed with GreenSeeker technology in order to determine the possibility of nitrogen stress management in cotton and to determine the differences between the normalized difference vegetative index (NDVI) and nitrogen doses determined with GreenSeeker, to determine the nitrogen deficiency and stress conditions by making use of the value of the NDVI in cotton production and to intervene when necessary and direct the producers in this regard. In the study six nitrogen doses (Control, 60, 120, 180, 240 and 300 kg ha-1) were used. The results showed significant differences between N applications for leaf chlorophyll content (SPAD), NDVI-2 (in the boll formation period), number of bolls (NB), seed cotton (SCY) and fiber yield (FY). On the other hand, there were non-significant differences in terms of (LA) area, NDVI-1 (in the beginning of the flowering), plant height (PH), node number of first fruiting branches (NNFFB), number of monopodial branches (NMB) and number of sympodial branches (NSB), number of nodes (NN), height to node ratio (HNR), seed cotton boll weight (SCBW) and ginning percentage (GP). The highest SCY and FY obtained were from doses of 180 and 120 kg ha-1 N, the highest leaf chlorophyll content and number of bolls obtained were from doses of 120 kg ha-1 N. The highest values of NDVI-2 obtained were from doses of 120, 240 and 300 kg ha-1 N, respectively. There were non-significant differences between N doses for values of the NDVI-1 of flowering, but significant differences observed for values of NDVI-2 of boll formation periods. The findings obtained from this research indicated that leaf chlorophyll and NDVI of the boll formation period can be used for determining differences due to varying N doses in cotton production.
MEMBANGUN MASYARAKAT BERKARAKTER,CERDAS DAN BERPRESTASI MELALUI POLITERPARK TAMAN POJOK LITERASI BERBASIS PENGETAHUAN UMUM DI SEKOLAH NEGERI 101867
Authors: Sinurat Hersakso , Situmorang Ria Monalisa , Lumban Gaol Rini Wana , Sianturi Rut Frida Yanti , Parhusip Excelsis Sarina , Harianja Ivana Riris , Saragih Dewi Satria
Published: April 2023

Pengabdian kepada masyarakat yang berjudul “Membangun Masyarakat Berkarakter,Cerdas Dan Berprestasi Melalui POLITERPARK (Taman Pojok Literasi Berbasis Pengetahuan Umum) Di Sekolah NEGERI 101867”di Yayasan Pendidikan tepatnya di SD Negeri 101867 Paya Gambar ini merupakan program yang direncanakan oleh LPPM (Lembaga Penelitian dan Pengabdian Masyarakat) yang dimana pengabdian kepada masyarakat menjadi mata kuliah wajib yang harus dilakukan oleh mahasiswa untuk mempersiapkan mahasiswa untuk menghadapi permasalahan yang akan terjadi ketika mengajar nanti. Melalui kegiatan ini juga mahasiswa diajarkan untuk mengimplementasikan ilmu yang sekiranya berguna untuk kehidupan bermasyarakat. Langkah yang dilakukan dalam program ini adalah penyuluhan/Sosialisasi pentingnya literasi baik bagi peserta didik SD Negeri 101867 Paya Gambar dengan output yang diharapkan yakni pandai membaca,menghargai serta menghormati guru dan orangtua,inovatif,jujur,disiplin suka bekerja keras dan cinta terhadap tanah air.Pengabdian kepada masyarakat merupakan pelaksanaan pengamalan ilmu pengetahuan, teknologi dan seni budaya langsung pada masyarakat secara kelembagaan melalui metodologi ilmiah sebagai penyebaran Tri Dharma Perguruan Tinggi serta tanggung jawab yang luhur dalam usaha mengembangkan kemampuan masyarakat, sehingga dapat mempercepat laju pertumbuhan tercapainya tujuan pembangunan nasional. Berikut manfaat pengabdian masyarakat, yaitu; Memberi dampak positif bagi masyarakat, Memperbanyak relasi, Meningkatkan saft skill dalam berkomunikasi, Belajar hal baru dan Menumbuhkan sifat simpati dan sabar (Herlina et al., 2022). Diharapkan PKM yang sudah dilaksanakan dapat bermanfaat pada masyarakat, terutama kepada : a. SD Negeri 101867 Paya Gambar, dan terlebih pada murid-murid SD Negeri 101867 Paya Gambar. b. Masyarakat lingkungan sekitar tempat mahasiswa mengabdi yaitu warga JL. Pancasila Dusun IV Paya Gambar . c. Universitas HKBP Nommensen d. Mahasiswa yang melaksanakan PkM.
Significado de la salud mental y actividad física en una comunidad de la zona costera
Authors: Meza-Vásquez Samuel , Delgado Margarita Vidal , Bruzzese Sonia Stevens , González María Pía Mardones , Sanzana Gladys Angélica Contreras , Farías Mariel Alejandra Lobos , Torres Felipe Antonio Albarrán , Peso Jacqueline Marlene Ibarra
Published: April 2023

La salud, se define como aquel estado de bienestar físico, mental y social, y no tan solo la carencia de enfermedades. En este contexto, la evidencia ha demostrado la relación que existe entre la actividad física y el efecto positivo sobre la salud mental:  aumento de la confianza, sentimientos de bienestar y mejora en la función cognitiva de la persona, disminución de la ansiedad, stress o depresión, asociadas a diversas comunidades. El objetivo de este estudio es describir el significado que se le atribuye a la salud mental y actividad física mediante el análisis de un recurso educativo audiovisual, en habitantes de la comunidad costera de la Región del Biobío. Chile. Estudio realizado bajo la metodología cualitativa con análisis mediante método de la teoría fundamentada. Se aplicó el instrumento grupo focal a una muestra de 12 habitantes de la zona costera de Caleta Lenga, región del Biobío, Chile. Los datos, se analizaron en tres etapas: la descripción (ordenamiento conceptual), la codificación, y la comparación constante de los hallazgos. El grupo focal contó con la aprobación del comité de ética de la UCSC y el consentimiento informado de los participantes. Respecto de los resultados, se definió 2 macro categorías: Actividad física y Salud mental. Así mismo, para la macro categoría Actividad física, se definió las subcategorías: Importancia deporte-buena salud, Juegos tradicionales, Falta de tiempo, Falta de incentivos-motivación, Transformación de la pesca. Por otro lado, para la macro categoría Salud mental, se determinó las subcategorías: Reconocimiento del fenómeno, Efectos de la pandemia, Dificultades económicas, Vinculo sistema educacional-comunidad, Importancia actividades de distracción, Religión como un factor protector. Se concluye que la actividad física es considerada como parte importante de la salud, ya que beneficia el estado de bienestar de las personas, pero, a su vez, se pone en evidencia la existencia de factores que generan la inactividad física. En relación a la salud mental, se distingue que la reciente situación sanitaria ha generado efectos negativos, atribuyéndole un significativo efecto perjudicial en diversas áreas de la vida y aspectos culturales, sociales y económicos.
Educational intervention to improve menstrual hygiene management in adolescent girls in Kalimantan, Indonesia
Authors: Nastit Aria Aulia , Triharini Mira , Pratiwi Ananda Hanna , Kamel Gouda Amel Dawod
Published: April 2023

Objective: To determine the effect of health education on menstrual hygiene management in adolescents.
Methods: The quasi-experimental study was conducted from April to July 2021 in Sampit, Kalimantan, Indonesia, after approval from ethics review committee of the Nursing University of Airlangga, Surabaya, East Java, Indonesia. The sample comprised grade VII female students at a public junior high school in Sampit. The sample was divided into intervention group A and control group B. Group A was given a health education intervention through video conferences in two meetings and was given a leaflet after each meeting which lasted 90 minutes. The control group was only given a leaflet. Baseline and post-intervention data was compared. Data was analysed using SPSS 16.
Results: There were 70 subjects; 35(50%) in each of the two groups. The age range was 12-14 years, with 25(71.4%) subjects in group A and 28(80%) in group B being aged 13 years. The age of menarche was 12 years for 17(48.6%) subjects in each of the two groups. Knowledge level of group A increased significantly post-intervention (p<0.05), but group B showed no significant difference (p=0.144).
Conclusion: Health education on menstrual hygiene management was found to have a beneficial influence on knowledge and attitudes among adolescents.
Keywords: Adolescent, Hygiene, Menstruation, Health education, Health knowledge, Attitudes, Practice.
Family caregivers’ perspective of caring for cancer patients during radiotherapy: a qualitative study
Authors: Dewi Lingga Curnia , Pratiwi Ika Nur , Nimah Lailatun , Ramoo Vimala
Published: April 2023

Objective: To explore the perspective of family caregivers of cancer patients undergoing radiotherapy.
 
Method: The descriptive, qualitative study was conducted at the Indonesia Cancer Foundation, Surabaya, Indonesia, in July and August 2019, and comprised family caregivers of cancer patients undergoing radiotherapy. Data was collected using in-depth semi-structured interviews which were recorded, transcribed and analysed using conventional content analysis.
 
Results: Of the 26 caregivers aged 24-65 years, 16(62%) were men, 19(73%) were married, and 14(56%) had close relationships with the patients. Among the patients, 4(15.4%) had breast cancer, 2(7.6%) had nasopharyngeal cancer and 20(77%) had cervical cancer. The themes identified were uncertainty, disintegration and burden.  
 
Conclusion: Caregivers of cancer patients tended to have both physical and emotional challenges.
 
Keywords: Caregivers, Adaptation, Psychological, Neoplasms, Cancer, Radiotherapy.
Nursing Needs and Peculiarities of Patients With Apllied Artificial Ventilation of Lungs in Intensive Care Unit From the Perspective of Nurses
Authors: Matelionytė Karolina , Daukšaitė Laura
Published: April 2023

Atificial pulmonary ventilation is prescribed in acute respiratory failure to help the patient ensure optimal blood circulation. Artificial lung ventilation is divided into invasive and non-invasive ventilation, and nurses must be able to ensure and maintain patients‘ vital functions.

Research aim – analyze the nursing need of intensive care unit patients undergoing mechanical ventilation from the perspective of nurses.

Research methods: analysis of scientific information sources, semi-structured interview, qualitative content analysis.

Most important results and conclusions. After summarizing the answers received by the subjects, it was found that in order to secure the respiratory system in patients, it is necessary pump secretions from the intubation or tracheostomy tube, monitor the cuff pressure, as well as minitor the risk of leakage of the air stream of non-invasive masks, properly perform the hygiene of the central venous catheter, the hygiene of the eyes and whole body, to prevent bedsores, using auxiliary means.

During study revealed that the specifics of nursing care are that patients with critical conditions are treated in the intensive care unit, requiring constant monitoring to minitor vital signs. Also has to perform a variety of nursing manipulations related to patient care, such as administering medications, regulating temperature, and meeting the needs of patients to eat and drink. The subjects distinguished that they must be able to prepare in time and quickly for complex procedures and to assist to the doctor.
The role of evidence in teaching practice from the point of view of the main actors
Authors: Olmos-Rueda Patricia , Pattier Daniel
Published: April 2023

The relationship between research and educational practice exerts a great deal of influence on the development of the teaching-learning process. Knowing the role played by evidence in teaching practice is essential in understanding education today and being able to design scenarios of improvement fostered by scientific evidence. With the goal of further examining the relationship between scientific evidence and educational practices on the one hand and teachers’ perception of the use of evidence on the other, a quantitative study was conducted via surveys administered to 462 teachers at schools in Barcelona and the Community of Madrid. The results show the importance that teachers attach to evidence and the characteristics that scientific evidence should have in order to have direct repercussions on teaching practice: relevance, approachability, accessibility, and practicality. What stands out is the value that teachers attach to the experiences of their own or others’ educational practices more than to theoretical knowledge. Furthermore, we can see how the variables of age, gender, educational level, educational level in which they teach, and ownership of the school condition the teachers’ perceptions of the relationship between scientific evidence and their educational practice. We conclude that these results enable key advances in the roadmap towards a culture of evidence-based practices in education and promote in-depth reflection on how research and its evidence effectively reach teachers.