bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 Vaccination among Czech Dentists
Authors: Schmidt Jan , Perina Vojtech , Treglerova Jana , Pilbauerova Nela , Suchanek Jakub , Smucler Roman
Published: March 2022

This work describes and evaluates vaccination against COVID-19 among members of the Czech Dental Chamber during the pre-booster vaccination phase. A cross-sectional online survey was conducted between 23 June and 4 September 2021, among 2716 participants, representing 24.3% of all chamber members. A total of 89.5% of respondents stated that they were registered for vaccination against COVID-19, their vaccination had started or been completed, or had a medically relevant reason to avoid vaccination. A total of 79.6% of respondents stated that they were fully vaccinated, most of them with the Comirnaty (Pfizer–BioNTech) vaccine (88.3%). The vaccination rate among males was significantly higher than among females (p = 0.001, OR 1.48). The main reasons for vaccination were professional (91.5%). The share of fully vaccinated participants was significantly higher (p < 0.0001, OR = 8.17) compared to the Czech general population (30.8%). A COVID-19 vaccine breakthrough infection rate was 0.42%. The study shows that both the willingness to vaccinate and the proportion of fully vaccinated individuals among Czech dentists are high, and only about 10% of them refused vaccination based on reasons classified as not medically relevant.
The Implications of Vaccines in Older Populations
Authors: Michel Jean-Pierre , Frangos Emilia
Published: March 2022

Mean longevity is increasing worldwide, with major consequences for public health worldwide, as the global population of adults aged over 65 years now exceeds the number of children under 5 for the first time in history. The ageing process over the life course is extremely heterogeneous, and it will be important to promote and enhance healthy ageing worldwide. Vaccination is a key player in the healthy ageing process, both at the individual and the community level. We review here the contribution of vaccines to individual and community health. At an individual level, we highlight the prevention of infectious diseases, as well as other, less well-known benefits of vaccination, such as modulation of the inflammatory process. We then underline the importance of vaccination in achieving herd immunity and reducing the transmission of pathogens in the community. Finally, at a community level, another important benefit of vaccination is the reduction in antimicrobial resistance. Taken together, these effects contribute to ensuring the best health, for the greatest number, for the longest time possible.
Waning Humoral Response after COVID-19 mRNA Vaccination in Maintenance Dialysis Patients and Recovery after a Complementary Third Dose
Authors: Biedunkiewicz Bogdan , Tylicki Leszek , Ślizień Waldemar , Lichodziejewska-Niemierko Monika , Dąbrowska Małgorzata , Kubanek Alicja , Rodak Sylwia , Polewska Karolina , Tylicki Piotr , Renke Marcin , Dębska-Ślizień Alicja
Published: March 2022

The aim of this study was to analyze the waning of anti-spike (S) antibodies after mRNA vaccination against COVID-19 in maintenance dialysis patients, and to assess the safety and effectiveness of the complementary third dose. This was a prospective, longitudinal study in which we analyzed the kinetics of antibodies up to six months after a two-dose vaccination (first protocol) in infection-naïve dialysis patients (IN-Ds), previously infected dialysis patients (PI-Ds) and subjects without chronic kidney disease (the controls), as well as their humoral response to the third dose of the same mRNA vaccine (second protocol). The respective reduction in antibody titer after 3 and 6 months by 82.9% and 93.03% in IN-Ds (n = 109), 73.4% and 93.36% in PI-Ds (n = 32) and 75.5% and 88.8% in the controls (n = 20) was demonstrated. Consequently, a protective antibody titer above 141 BAU/mL was found in only 47.7% and 23.8% of IN-Ds after 3 and 6 months, respectively. After the third vaccine dose, a significant increase in antibody titer was observed in all groups, with increases by a factor of ×51.6 in IN-Ds, ×30.1 in the controls and ×8.4 in PI-Ds. The median antibody titer after the third dose differed significantly between groups, and was the highest in PI-Ds: PI-Ds, 9090 (3300–15,000) BAU/mL; the controls, 6945 (2130–11,800); IN-Ds, 3715 (1470–7325) (p < 0.001). In conclusion, we observed similar degrees of antibody waning in all patients. After 3 months, over half of the infection-naïve dialysis patients had a very low antibody titer, and almost twenty percent of them had no antibodies at all. The humoral response to the third dose was very good, raising their titer of antibodies to a higher level than those in the general population who have received the primary two-dose scheme. The results support the administration of a complementary third dose of the mRNA vaccine for dialysis patients as soon as possible.
Safety Profile of COVID-19 Vaccines among Healthcare Workers in Poland
Authors: Paczkowska Anna , Hoffmann Karolina , Michalak Michał , Hans-Wytrychowska Anna , Bryl Wiesław , Kopciuch Dorota , Zaprutko Tomasz , Ratajczak Piotr , Nowakowska Elżbieta , Kus Krzysztof
Published: March 2022

The aim of the study was to compare the safety profiles (prevalence of both local and systemic side effects) of COVID-19 vaccines (Pfizer–BioNTech, Moderna, Oxford–AstraZeneca) among healthcare workers (doctors, nurses, and pharmacists) administered with a first and a second dose of the vaccines. Another goal of the research was to evaluate potential demographic and clinical risk factors for the frequency and intensity of side effects. A post-marketing, cross-sectional survey-based study was carried out on a sample of 971 respondents (323 doctors, 324 nurses, and 324 pharmacists), all more than 18 years old, who have taken two doses of the following SARS-CoV-2 vaccines: BNT162b2 (Pfizer–BioNTech) (group 1), mRNA-1273 (Moderna) (group 2), and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) (group 3). A validated, self-administered questionnaire was developed and delivered online to the target population group of healthcare workers. The survey was conducted during the third wave of the COVID-19 (1 February 2021–1 July 2021) pandemic. It was based on the CAWI (computer-assisted web interview) method. Questionnaires were disseminated using selected social media. The BNT162b2 (Pfizer–BioNTech) vaccine was the most commonly administered COVID-19 vaccine among healthcare professionals in Poland (69.61%). Side effects following a SARS-CoV-2 vaccine were reported by 53.11% of respondents in group 1, 72% in group 2, and 67.59% in group 3. The following were the most common side effects regardless of the type of vaccine administered: pain at the injection site, headache, muscle pain, fever, chills, and fatigue. The number and intensity of reported side effects following administration of a BNT162b2 (Pfizer–BioNTech) vaccine were significantly lower than in the other two study groups (p < 0.00001). Risk factors for side effects following administration of one of the SARS-CoV-2 vaccines subject to the analysis included being female, young, and suffering from a diagnosed allergy. Our results clearly show that the short-term safety profiles of the eligible COVID-19 vaccines (Pfizer–BioNTech, Moderna, Oxford–AstraZeneca) are acceptable. Nevertheless, the two-dose COVID-19 vaccines available in Poland differ significantly in the frequency of both local and systemic side effects and their intensity. Women, young people, and patients diagnosed with allergies are particularly exposed to the risk of side effects. Further studies are needed to determine the long-term safety profile of COVID-19 vaccines.
VSV-Based Vaccines Reduce Virus Shedding and Viral Load in Hamsters Infected with SARS-CoV-2 Variants of Concern
Authors: O’Donnell Kyle L. , Gourdine Tylisha , Fletcher Paige , Shifflett Kyle , Furuyama Wakako , Clancy Chad S. , Marzi Andrea
Published: March 2022

The continued progression of the COVID-19 pandemic can partly be attributed to the ability of SARS-CoV-2 to mutate and introduce new viral variants. Some of these variants with the potential to spread quickly and conquer the globe are termed variants of concern (VOC). The existing vaccines implemented on a global scale are based on the ancestral strain, which has resulted in increased numbers of breakthrough infections as these VOC have emerged. It is imperative to show protection against VOC infection with newly developed vaccines. Previously, we evaluated two vesicular stomatitis virus (VSV)-based vaccines expressing the SARS-CoV-2 spike protein alone (VSV-SARS2) or in combination with the Ebola virus glycoprotein (VSV-SARS2-EBOV) and demonstrated their fast-acting potential. Here, we prolonged the time to challenge; we vaccinated hamsters intranasally (IN) or intramuscularly 28 days prior to infection with three SARS-CoV-2 VOC—the Alpha, Beta, and Delta variants. IN vaccination with either the VSV-SARS2 or VSV-SARS2-EBOV resulted in the highest protective efficacy as demonstrated by decreased virus shedding and lung viral load of vaccinated hamsters. Histopathologic analysis of the lungs revealed the least amount of lung damage in the IN-vaccinated animals regardless of the challenge virus. This data demonstrates the ability of a VSV-based vaccine to not only protect from disease caused by SARS-CoV-2 VOC but also reduce viral shedding.
Performance of Slow-Growing Chickens Fed with Tenebrio molitor Larval Meal as a Full Replacement for Soybean Meal
Authors: Nieto Jaime , Plaza Javier , Lara Javier , Abecia José-Alfonso , Revilla Isabel , Palacios Carlos
Published: March 2022

Insect larval meal is an increasingly common protein source in poultry systems. In this study, the effect of replacing soybean meal with Tenebrio molitor larval meal on the performance of slow-growing chickens was assessed. A total of 128 one-day-old chickens (Colorield) were randomly divided into a control group (C) (n = 64), fed with soybean meal, and an experimental group (TM) (n = 64), fed with T. molitor larvae meal. The chicks were slaughtered after 95 days. Three different isoenergetic and isoproteic diets (F1, F2 and F3) were used for each group. The F1 diet resulted in higher body weight gain and higher feed and water intakes in group C, but a lower feed conversion ratio. Contrarily, diets F2 and F3 did not produce differences in the studied parameters between the two groups, except for body weight gain in the case of diet F2, which was highest in group C. Therefore, weight gain and feed and water intakes were significantly higher in group C, but there were no differences in feed conversion ratio or live weight. In conclusion, the total replacement of soybean meal with T. molitor larvae meal resulted in a reduction in feed intake and a consequent reduction in weight. During this period, partial rather than total substitution may be recommended.
Reverse Osmosis Membrane Combined with Ultrasonic Cleaning for Flue Gas Desulfurization Wastewater Treatment
Authors: Chen Xingyu , Li Tianxin , Dou Xiaomin , Meng Linglong , Xu Shuiyang
Published: March 2022

Flue gas desulfurization (FGD) wastewater treatment is currently of interest, as stringent standards have been released in order to limit the pollution emissions from the energy industry, and concerns about water scarcity are also increasing. Reverse osmosis (RO) membrane is a promising alternative for highly efficient FGD wastewater treatment. However, membrane fouling strongly limits its application. This study developed a suitable treatment system by combining RO membrane with ultrasonic cleaning. The introduction of low-frequency and high-intensity ultrasonic cleaning improved the cleaning efficiency of membrane fouling, as the permeate flux recovered 49% of the reduced value within 10 min of cleaning. The lifespan of the membrane was also extended, as the time of permeate flux declined to the same level, increasing from 2 h to 4 h after ultrasonic cleaning. The effluent of the system could meet the standard of desulfurization wastewater treatment. The treatment system is feasible for FGD wastewater treatment at a laboratory scale. These findings proved that the combination of RO membrane and ultrasonic cleaning could be applied to FGD wastewater treatment. The study provided an efficient, cost-saving, and convenient way to develop the FGD wastewater treatment system.
A New Method of Estimating Groundwater Evapotranspiration at Sub-Daily Scale Using Water Table Fluctuations
Authors: Su Yonghong , Feng Qi , Zhu Gaofeng , Wang Yunquan , Zhang Qi
Published: March 2022

Riparian ecosystems fundamentally depend on groundwater, and accurate estimations of groundwater evapotranspiration (ETG) are important for understanding ecosystem functionality and managing regional water resources. Over the past several decades, various methods have been proposed to estimate groundwater evapotranspiration based on water table fluctuations. However, the majority of methods cannot resolve sub-daily variations in ETG. In this study, we proposed a new hydraulic theory-based ETG estimation method at a sub-daily time scale. To evaluate its performance, we employed a variety of measurements (i.e., water table levels, latent heat flux and soil water contents) at a riparian forest (T. ramosissima) in Northwest China from 25 July to 10 October in 2017. The results indicated that the proposed method can successfully estimate ETG at both sub-daily (R2 = 0.75) and daily (R2 = 0.88) time scales, but the variations in the specific yield under different water table conditions should be carefully taken into account. In addition, we investigated the seasonal variations in water uptake source of the riparian plant, and found that it had strong plasticity in water usage during the study period. That is, it consumed approximately equal amounts of soil water and groundwater when soil moisture was available, and tended to consume more groundwater for survival as the soil moisture was depleted. To verify the seasonal patterns of the water uptake of the riparian forest, systematic isotope-based studies are needed in future study.
Assessing the Variances of Citizen Stakeholder Justice in Watershed Governance: Is Action More Effective with Reactive or Proactive Administrations
Authors: King Hayden , Guehlstorf Nicholas
Published: March 2022

Watershed governance has historically been administered by natural resource experts and is often inaccessible to citizen stakeholders. Although many advocate for deliberative democracy as a pathway toward natural resource sustainability, others remain skeptical due to perceived tradeoffs. Environmental deliberative democracy (EDD) serves as a conceptual synthesis of collaborative principles. This research compares the social, economic, and political discourses in two Wisconsin watersheds (Geneva Lake in regulatory compliance and Green Lake, which is deemed state impaired) and posits that EDD community compatibility is enhanced by public trust in expert capacity and accessible watershed education resources. A mixed methodology is used to analyze quantitative data from citizen surveys and qualitative interview responses. Findings affirm that proactive watershed management frameworks are stronger when not prompted by environmental crises. Management programs created reactively with a specific agenda have a comparable structure with citizen involvement but have a limited capacity, scope, and potential for sustained success.
Efficiency of Geospatial Technology and Multi-Criteria Decision Analysis for Groundwater Potential Mapping in a Semi-Arid Region
Authors: Masoud Ahmed M. , Pham Quoc Bao , Alezabawy Ahmed K. , El-Magd Sherif A. Abu
Published: March 2022

The increasing water demand in Egypt causes massive stress on groundwater resources. The high variability in the groundwater depth, aquifer properties, terrain characteristics, and shortage of rainfall make it necessary to identify the groundwater potentiality in semi-arid regions. This study used the possibilities of multi-criteria decision approaches (MCDA), geographical information system (GIS), and groundwater field data to delineate potential groundwater zones in the Tushka area, west of Lake Nasser, South Egypt. Furthermore, groundwater potentiality identification can help decision-makers better plan and manage the water resources in this promising area. Eight controlling factors were utilized to achieve the objective of the present work using multi-criteria decision analysis (MCDA) approaches, namely the analytical hierarchy process (AHP) and frequency ratio (FR) models. The controlling parameters were integrated with the geographic information system (GIS) to develop the zones of groundwater potentialities. The results revealed that high and moderate-potential zones cover approximately 61% and 52% of the total area in the AHP and FR models, respectively. A total of 44 groundwater production wells along with the well yield were collected and used to validate the models. The results were evaluated using the receiver operating characteristics (ROC) curve. The best-performing prediction rates achieved by AHP and FR were 83% and 81%, respectively. Finally, the obtained results indicated that the AHP model achieved better performance than the FR model.
Effects of Orifice Sizes for Uncontrolled Filling Processes in Water Pipelines
Authors: Aguirre-Mendoza Andres M. , Paternina-Verona Duban A. , Oyuela Sebastian , Coronado-Hernández Oscar E. , Besharat Mohsen , Fuertes-Miquel Vicente S. , Iglesias-Rey Pedro L. , Ramos Helena M.
Published: March 2022

The sizing of air valves during the air expulsion phase in rapid filling processes is crucial for design purposes. Mathematical models have been developed to simulate the behaviour of air valves during filling processes for air expulsion, utilising 1D and 2D schemes. These transient events involve the presence of two fluids with different properties and behaviours (water and air). The effect of air valves under scenarios of controlled filling processes has been studied by various authors; however, the analysis of uncontrolled filling processes using air valves has not yet been considered. In this scenario, water columns reach high velocities, causing part of them to close air valves, which generates an additional peak in air pocket pressure patterns. In this research, a two-dimensional computational fluid dynamics model is developed in OpenFOAM software to simulate the studied situations.
Spatial Distribution of Ciliate Assemblages in a Shallow Floodplain Lake with an Anaerobic Zone
Authors: Babko Roman , Kuzmina Tetiana , Danko Yaroslav , Pliashechnyk Volodymyr , Szulżyk-Cieplak Joanna , Łazuka Ewa , Zaburko Jacek , Łagód Grzegorz
Published: March 2022

The spatial distribution of ciliate assemblages was studied in a shallow floodplain lake with a sharp division of space by oxygen conditions. The surface zone occupied by the “carpet” of Lemna trisulca and L. minor was characterized by a large daily amplitude of oxygen content with periodic exceeding of 100% of saturation; the underlying water layer was characterized by microaerobic conditions throughout most of the year, with seasonal deviations towards oxygen-free conditions (in winter and mid-summer) or increased oxygen content (before freezing and after ice melt); stable oxygen-free conditions were maintained in the bottom layer of water and at the bottom of the lake. There were 111 species of ciliated protozoa recorded in the lake. The ciliated protozoa were clearly structured and formed three almost non-overlapping assemblages in terms of species composition, which retained their isolation during all seasons of the year. On the basis of the analysis performed using the R indicspecies package, species of ciliated protozoa were identified as indicators of conditions with different oxygen regimes, which are determined by the level of organic pollution and the distribution of photosynthetic organisms.
Physiological and Biochemical Responses of Kandelia obovata to Upwelling Stress
Authors: Li Xiaomei , Wang Youshao , Dong Junde , Wu Meilin
Published: March 2022

Mangroves growing in intertidal areas are faced with various stresses caused by coastal human activities and oceanic and atmospheric sources. Although the study of the physiological and biochemical characteristics of mangroves has been developing over the past four decades, the effect of upwelling on mangroves in plants stress resistance has seldom been investigated. Here, changes in the physiological and biochemical characteristics of the leaves of Kandelia obovata seedlings in response to upwelling were investigated (air temperature: 25 °C; water temperature: control 25 °C, 13 °C, and 5 °C; salinity: 10‰). The results revealed that upwelling treatment caused an increase in chlorophyll content but a decrease in photosynthetic fluorescence parameters. Hydrogen peroxide (H2O2) production and malondialdehyde activity (MDA) increased with the decrease in upwelling temperature. The proline content increased under upwelling stress, whereas the soluble sugar content decreased. Further, the activities of antioxidant enzymes, such as superoxide dismutase activity (SOD) and peroxidase activity (POD), showed an increasing trend during the treatment, while catalase activity (CAT) decreased. It was evidenced that upwelling stress triggered the physiological and biochemical responses of Kandelia obovata seedlings. This effect became more intense as the upwelling temperature decreased, and all these indicators showed different responses to upwelling stress. Through synthesizing more energy and regulating enzyme activity and osmotic pressure, the leaves of K. obovata formed a resistance mechanism to short-term upwelling.
Outcomes of reconstructive periodontal surgery with different types of barrier membranes
Authors: Perova M. D. , Ananich A. Yu. , Sevostyanov I. A. , Fedorov I. I. , Ovcharenko E. S. , Samokhvalova D. D.
Published: March 2022

Relevance. Reconstructive periodontal surgery is one of the most effective methods of restoring tooth-supporting apparatus damaged by microbial inflammation and destruction. For this purpose, they use non-resorbable and resorbable biomaterials, which act as a temporary barrier between the tissues with different mitotic potential during early healing. Since the properties of barrier membranes determine the degree of invasiveness and postoperative morbidity, and, finally, the success of the surgery, it is relevant to study the outcomes of periodontal reconstruction with one of the modern collagen membranes cross-linked by ribose.Purpose. To comparatively assess the outcomes of periodontal reconstructions with a resorbable and non-resorbable barrier material.Material and methods. The study is a prospective randomized blind controlled clinical trial. The study included 37 patients (14 men, 23 women) aged 45-65 years, who, after the initial therapy, underwent 62 guided tissue regenerations using e-PTFE and resorbable collagen membrane cross-linked by ribose. The study compared the clinical and radiographic results before and 18 months after the surgery. We evaluated the probing depth (periodontal pocket), gingival recession level, loss of clinical attachment level, width and height of periodontal infrabony defects, gain in clinical attachment level. The material was statistically processed using StatSoft STATISTICA 10.0.1011 for Windows. The statistical unit is a periodontal defect.Results. In the postoperative period, the main (31%) and control (42%) groups exhibited the areas of membrane exposure; 16 periodontal defects, only in the control group, demonstrated the extensive membrane exposure, of which 11 membranes were prematurely removed due to infection of the reconstruction site. In the main group, fibrin allowed exposed area healing in the usual time without medical assistance. After 18 months, the gain in the clinical attachment level was 3.5 mm in the main group versus 2.8 mm in the control group (at p=0.03) with a significant decrease in the probing depth compared to that before treatment; the level of recession also changed positively, although not significantly. The type of periodontal defect (the parameter is higher in three-wall and two-wall defects) appeared to remarkably influence the gain in clinical attachment level.Conclusion. The study evidenced that the resorbable cross-linked collagen membrane demonstrated clinically acceptable outcome of the damaged periodontium reconstruction due to, first of all, increased predictability of the course of the early postoperative period, a significant reduction in morbidity and invasiveness of intervention.
Periodontal diseases and non-alcoholic fatty liver disease
Authors: Kerimov Kh. N. , Arutyunov S. D. , Malova E. S. , Morozov V. G. , Degtyareva Y. S. , Kharakh Y. N. , Balmasova I. P. , Tsarev V. N.
Published: March 2022

Relevance. Periodontal diseases, being an extremely common, do not only cause tooth loss and significantly affect the patients’ quality of life, but are also a risk factor for many systemic diseases and may subsequently aggravate their course. Non-alcoholic fatty liver disease (NAFLD) is one of the relatively understudied pathologies associated with periodontal diseases.Materials and methods. A non-interventional study analytically reviewed Russian and international scientific publications, which presented the results of independent clinical and laboratory studies on the topic from 2011 to 2021.Results. Scientific literature data evidence that NAFLD manifests by impaired lipid metabolism in liver cells, linked with mechanisms regulated by the liver nuclear receptors (LXR), and leads to such life-threatening conditions as liver cirrhosis and hepatocellular carcinoma. The information on the role of periodontal pathogens in NAFLD development has been accumulated by now. The example of such principal periodontal pathogen as Porphyromonas gingivalis experimentally demonstrated that it can integrate into the intestinal microbiome, migrate through the bloodstream to the liver, survive in hepatocytes and influence the nuclear receptors of these cells affecting the lipid metabolism and contributing to NAFLD development.Conclusion. A detailed study of the link between periodontal disease and non-alcoholic fatty liver disease may contribute to the development of new effective strategies for the diagnosis and treatment of these pathological conditions.
The link between age-related dental syndromes and some oral predictors of ageing
Authors: Sementsova E. A. , Mandra J. V. , Bazarnyi V. V. , Polushina L. G. , Grigoryev S. S. , Elovikova T. M. , Svetlakova E. N. , Zhegalina N. M.
Published: March 2022

Relevance. Ageing is an important factor causing various diseases and functional failure. Ageing markers help to characterize the ageing process comprehensively. Currently, molecular and genetic human ageing markers are the most promising (Molecular / DNA-Based Markers).The study aimed to identify the relationship between age-related dental syndromes and some oral predictors of ageing.Materials and methods. The study included 200 elderly patients, aged 60-74 years, according to the WHO classification. The patients were divided into 3 groups based on the detected clinical dental syndrome (occlusive, periodontal, dystrophic). In all patients, we collected non-stimulated oral fluid. The oral fluid immunochemical examination determined BCL-2 (B Cell Lymphoma 2), Caspase 3, Cytochrome C, GAPDH (Glyceraldehyde 3-Phosphate Dehydrogenase), Cleaved PARP (Poly (ADP-ribose) polymerase) and p53, using the method of the multi-parametric fluorescent analysis with magnetic microspheres.Results. According to the immunochemical study, the patients with dystrophic syndrome demonstrated the highest concentration of apoptosis markers, with the occlusal syndrome – the lowest. Periodontal syndrome exhibited a moderate level of oral fluid ageing predictors.Conclusion. Determining the apoptosis marker level in the oral fluid may have practical clinical use in the customized diagnosis of predisposition to the principal age-related dental syndromes, as well as systemic comorbidity. Early diagnosis of diseases at the initial stage allows us to give patients timely recommendations to correct their lifestyle, habits, medication intake.
The study of toothpaste desensitizing properties
Authors: Ulitovskiy S. B. , Kalinina O. V. , Leontev A. A. , Khabarova O. V. , Pankrateva L. I. , Soloveva E. S. , Fok N. K.
Published: March 2022

Relevance. Over the past decade, manufacturers of oral care products have expanded the possibilities of solving the problem of hypersensitivity of teeth due to a variety of new modern technologies, which provides an opportunity to increase the effectiveness of active oral care product components. The study aimed to investigate desensitizing, remineralizing and anti-caries effectiveness of Asepta Extra Sensitive toothpaste to confirm the toothpaste properties stated by the manufacturer. Material and methods. Forty-nine people, aged from 24 to 58 years, participated in the clinical testing of the toothpaste. The study used the Orekhova – Ulitovskiy tooth sensitivity index to evaluate the desensitizing toothpaste and determined the severity of dental hyperesthesia using diagnostic tests. We objectively assessed the functional state of the enamel using the Okushko – Kosareva enamel resistance test. The study evaluated the electrical conductivity of the dentin hypersensitivity to investigate the anti-caries effect.Result. The desensitizing effectiveness increased to 64.59 ± 5.72% by the end of the study, according to the Orekhova – Ulitovskiy sensitivity index. The dentin hypersensitivity hypersensitivity decreased, according to the diagnostic tests. The tooth sensitivity reduction effectiveness increased – 62.22 ± 6.84%, according to the tooth tactile sensitivity assessment by linear advancement of the probe along the tooth surface. The analysis of the remineralizing parameter showed positive changes in the enamel resistance test. The remineralizing parameter value amounted to 21.49 ± 1.91%, and the remineralizing effectiveness reached 61.05 ± 2.98%. The values of anti-caries action and anti-caries effectiveness were 3.31 ± 0.52 mA and 29.72 ± 1.92%, respectively, according to the method of dentin hypersensitivity electrical conductivity evaluation with Asepta Extra Sensitive toothpaste. The desensitizing, remineralizing and anti-caries results of Asepta Extra Sensitive toothpaste use were high.Conclusion. The development of dental health strengthening measures determines the significance of oral care products in tooth sensitivity prevention in the population, which plays a leading role in planning individual programs to prevent major dental diseases.
What has been done in the fight against Varroa destructor: from the past to the present
Authors: GREGORC Ales , DOMİNGUES Caio , TUTUN Hidayet , SEVİN Sedat
Published: March 2022

Bees are the major pollinators in natural ecosystems and in the agricultural production of several crops used for human consumption. However, they are exposed to multiple stressors that are causing a serious decline in their population. We highlight a major one among them, the Varroa destructor mite (Varroa) that causes severe impacts on the health of honey bee colonies, transmitting a variety of viruses that can affect the survival ability of individual bees and entire colonies. Diagnosis and mite control methods have been intensively studied in recent decades, with many studies in different areas of knowledge having been conducted. This overview summarizes these studies with a focus on colony defense systems, biological characteristics of the parasite Varroa, diagnostic methods used to establish the infestation level of colonies, and currently used control methods.
Point-of-care NT-proBNP monitoring for heart failure: observational feasibility study in primary care
Authors: Chami Jason , Fleming Susannah , Taylor Clare J , Bankhead Clare R , James Tim , Shine Brian , McLellan Julie , Hobbs FD Richard , Perera Rafael
Published: March 2022

Background

Around one million individuals in the UK have heart failure (HF), a chronic disease that causes significant morbidity and mortality. N-terminal pro-B-type natriuretic peptide (NT-proBNP) monitoring could help improve the care of patients with HF in the community.

Aim

The aim of this study is to provide evidence to support the routine use of point-of-care (POC) NT-proBNP monitoring in primary care.

Design & setting

In this observational cohort study, the Roche Cobas h 232 POC device was used to measure NT-proBNP in 27 patients with HF at 0, 6, and 12 months, with a subset reanalysed in the laboratory for comparison.

Method

Data were analysed for within-person and between-person variability and concordance with laboratory readings using Passing–Bablok regression. GPs reported whether POC results impacted clinical decisionmaking, and patients indicated their willingness to participate in long-term cohort studies using the Likert acceptability scale.

Results

Within-person variability in POC NT-proBNP over 12 months was 881 pg/mL (95% confidence interval [CI] = 380 to 1382 pg/mL). Between-person variability was 1972 pg/mL (95% CI = 1,525 to 2791 pg/mL). Passing–Bablok regression showed no significant systematic difference between POC and laboratory measurements. Patients indicated a high level of acceptability, and GP decisionmaking was affected for at least one visit in a third of patients.

Conclusion

Within-person variability in POC NT-proBNP is around half of between-person variability, so detecting changes could be of use in HF management. High patient acceptability and impact on clinical decisionmaking warrant further investigation in a larger long-term cohort study.
Relación entre el trabajo cooperativo y la capacidad de interpretación en las formas musicales
Authors: de Paz Quispe Arnold Ives , Gálvez Veliz Daniel , Tarazona Padilla Armando Wilfredo
Published: March 2022

Las bandas reúnen un conjunto de músicos los cuales, de forma coordinada, realizan melodías que pretenden ser satisfactorias para los oyentes. El objetivo de estudio fue determinar la relación entre el trabajo cooperativo y la capacidad de  interpretar  las  formas   musicales. Se empleó como método el enfoque cuantitativo con diseño correlacional, realizado con una población censal o muestra intencional de 151 estudiantes miembros de la Universidad  Nacional de Música, a  quienes  se  les  aplicó  dos cuestionarios en escala de Likert, para  medir  la  percepción  de  cada  una de las variables. Los resultados obtenidos mediante el  procesamiento del software SPSS 26, demostraron una Correlación de Spearman de .403. Se concluyó que, existe relación entre el trabajo cooperativo y la capacidad de interpretación en las formas musicales.
Dramaturgia para las infancias en el siglo XX en Tandil: Martino Gomaespuma de Eugenio Deoseffe y Catalina Landivar
Authors: Fuentes Teresita María Victoria
Published: March 2022

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Rapid Detection Test for COVID-19 among Healthcare Workers and the Role of Personal Protective Equipment
Authors: Hajiabdolbaghi Mahboubeh , Aryannejad Armin , Tabary Mohammadreza , Farhangi Pourya , Abdollahi Alireza , Ghaderkhani Sara , Amini Mostafa , Kimyaee Elaheh , Ranjbar Athareh , Salehi Mohammadreza , Ghiasvand Fereshteh , Meidani Mohsen , Hasannezhad Malihe , Mohammadnejad Esmaeil , Hadipour Mahnaz , Araghi Farnaz , Mashinchi Baharnaz , Seifi Arash
Published: March 2022

Background: In this study, we assessed the prevalence of positive rapid detection test (RDT) among healthcare workers (HCWs) and evaluated the role of personal protective equipment (PPE) and knowledge of the pandemic. Methods: In a cross-sectional study conducted between August 2020 and October 2020 in a tertiary referral center (Tehran, Iran), we enrolled 117 physicians, nurses, and other HCWs (OHCWs)—aides, helpers, and medical waste handlers—regularly working in coronavirus disease 2019 (COVID-19) wards. The RDT kit was utilized to reveal recent infection; data on demographics, PPE use and availability, and knowledge of the pandemic was collected through pre-defined questionnaires. Results: Overall, 24.8% (95% CI: 16.8–32.7%) of HCWs had positive RDTs. The more PPE was available and used, the less the chance of positive RDT was (OR: 0.63 [0.44–0.91], P = 0.014 and 0.63 [0.41–0.96], P = 0.030). The same was true for the knowledge of prevention and adhering to preventive rules (OR: 0.44 [0.24–0.81], P = 0.008 and 0.47 [0.25–0.89], P = 0.020). OHCWs had the highest prevalence of positive RDT, while they had more shifts per month, less accessibility to PPE, and less knowledge of the pandemic than physicians. Conclusion: The findings of this study suggest that HCWs should have a thorough knowledge of the pandemic along with using PPE properly and rationally. Furthermore, adhering to preventive regulations plays a crucial role in HCWs’ safety. It is also noteworthy that shifts should be arranged logically to manage exposures, with a special attention being paid to OHCWs.
Abdominal Ultrasound Combined with Laboratory Tests as a Reliable, Easily Accessible and Cost-Effective Way of Assessing the Stages of Liver Fibrosis and Cirrhosis
Authors: Montazeri Ghodratolllah , Rohban N. , Sotoudeh Masoud , Massarrat Sadegh
Published: March 2022

Background: In the last two decades, the simple low-cost abdominal ultrasound (US) examination for the diagnosis of advanced fibrosis and cirrhosis was displaced by very expensive and not readily available modern imaging systems like magnetic resonance imaging (MRI), computed tomography (CT) scan and transient elastography. The aim of this study is to evaluate and emphasize the potential of US for diagnosis of advanced liver fibrosis and cirrhosis. Methods: US, laboratory tests (blood counts, transaminases, aspartate platelet ratio index [APRI], international normalized ratio [INR], serum albumin and bilirubin) and liver biopsy were performed on 197 patients with chronic liver diseases. Development of liver fibrosis was categorized in six stages, with stages 1–3 considered as mild to moderate and stages 4–6 as advanced fibrosis. Sonographic parameters (interrupted liver surface line, nodularity of liver surface, biconvexity of liver edges, grade of liver angle, caudate lobe diameter, parenchyma echotexture and spleen size) were obtained. All variables were dichotomized into zero and one and compared with respect to the different stages of liver fibrosis. The sensitivity, specificity, and positive and negative predictive values of all variables as well as their summations scores through receiver operating characteristic (ROC) curve analysis were calculated for the correct histologic diagnosis. Results: Totally, 39 cases had severe fibrosis and cirrhosis and 158 had mild to moderate fibrosis. The area under the curve by ROC curve analysis of sonographic variables (surface nodularity, angle of left lobe, echotexture of liver and spleen size) was 85%, that of laboratory data (APRI, serum albumin and INR combined) was 83.8%, that of APRI alone was 81.8% and all combined (sonography and lab data together) was 92.4% for the correct diagnosis. Conclusion: The simple US examination, alone or combined with lab data, is able to diagnose advanced fibrosis and cirrhosis with excellent accuracy, making the use of other modern imaging modalities unnecessary.
KINERJA REKSA DANA SAHAM SYARIAH DI BURSA EFEK INDONESIA
Authors: Kosim Belliwati , Fitriah Wani
Published: March 2022

Mutual fund is such an alternative which offers convenience for investors who want to invest with limitedfunds, especially small investors who do.not have much time in understanding investment performance and have nocapability to calculate the risk of the investment they have. This research was aimedat determining the performance of syariah mutual fund on the Indonesia stock exchange. The type oflhis research was a descriptive-quantitative approach. The population of this research was sharia equity mutual funds on the Indonesia Stock Exchange within January 2014-2018. To get the sample of the research, purposive samplingwas applied. There were 24 sharia equity funds as samples used. The data analysis method used was a quantitative method. The results of the study using the Sharpe method for all syariah equity funds have negative performance, the Treynor method has 6 sharia equity funds that have positive performance, namely Lautandhana Syariah Mutual Funds, Mandiri Investa Syariah Berimbangh, AAA Amanah Syariah Fund, CIMB-Principal Islamic Sharia Equity Growth, Batavia Sharia Stock Funds, Cipta Syariah Balance and Jensen, there are only 3 Syariah equity mutual funds that have positive performance, namely Schroder Syariah Balanced Fund, Sharia Pacific Balance and Cipta Syariah Balance.
Remaja Mengenali Serangan Jantung Koroner
Authors: Apriyatmoko Raharjo , Aini Faridah
Published: March 2022

The involvement of all components in society including adolescents is important to reduce the high number of deaths due to heart attacks. But various health programs in school have not touched on the topic. Through community service with a participatory approach-based health education is expected to improve adolescents' ability to handle heart attacks. The participatory approach involves fully the role of all related components in planning, implementing and evaluating the program. Program procedures include preparation stage, participant recruitment, training, and evaluation monitoring. The recruitment results included 56 students who were active in Youth Red Cross activities. Preliminary measurement shows 87.86% of students have less knowledge and ability in coronary heart disease. An increase in significantly was shown after the program was run, where there was a 70% increase in good categorie. The method used can be said to be effective in improving adolescent abilities. There needs to be ongoing action on the program in particular improving young men's involvement and strengthening students' motivation to share their knowledge and hone skills through ongoing coaching programs.AbstrakKeterlibatan semua komponen di masyarakat termasuk remaja penting untuk mengurangi tingginya kematian akibat serangan jantung. Namun berbagai program kesehatan pada anak sekolah belum menyentuh topik tersebut. Melalui pengabdian masyarakat dengan pendidikan kesehatan berbasis pendekatan partisipatif diharapkan dapat meningkatkan kemampuan remaja dalam penanganan serangan jantung. Pendekatan partisipatif melibatkan secara penuh peran semua komponen terkait dalam merencanakan, melaksanakan dan mengevaluasi program. Prosedur program yang dijalankan meliputi tahap persiapan, perekrutan peserta, pelatihan, serta monitoring evaluasi. Hasil perekrutan mendapatkan peserta sejumlah 56 siswa yang aktif dalam kegiatan Palang Merah Remaja. Pengukuran awal menunjukkan 87,86% siswa memiliki pengetahuan dan kemampuan yang kurang dalam penyakit jantung koroner. Peningkatan siknifikan ditunjukkan setelah program dijalankan, dimana terjadi peningkatan pada katagori baik sebesar 70%. Metode yang digunakan dapat dikatakan efektif dalam peningkatan kemampuan remaja. Perlu ada tindakan berkelanjutan pada program khususnya peningkatan keterlibatan remaja pria dan penguatan motivasi siswa untuk menyebarkan pengetahuan yang dimiliki dan mengasah ketrampilan melalui program pembinaan berkelanjutan.
Relationship between Affective Commitment and Work Engagement in Employees of Savings and Loans Cooperatives in Kupang City
Authors: Koroh Tirza Risma , Keraf M. K. P. Abdi , Damayanti Yeni
Published: March 2022

Micro, Small, and Medium Enterprises (MSME) and cooperatives in NTT, especially in the city of Kupang, have a strategic role in the economic development of the community, especially in overcoming poverty. This makes organizations pay important attention to Organizational Commitment, especially the affective commitment that employees have so that services can be carried out properly. This study aims to determine the relationship between affective commitment and work engagement among cooperative employees in Kupang City. The type of research used is quantitative research with correlational methods. Sampling using purposive sampling technique with a total sample of 81 employees who work in cooperatives in Kupang City. Data collection used is a modification of the affective commitment scale developed by Meyer, Allen & Smith (1993) and an adaptation of the work engagement scale developed by Schaufeli & Bakker (2004). The analysis technique uses Pearson Product Moment Correlation and shows that there is a significant relationship between affective commitment and work engagement where the Pearson Correlation value= 0.225 with a significance of 0.044. This shows that employees who work in cooperatives in Kupang City have high work engagement and affect the level of affective commitment shown in the cooperative where they work.
The Experience as a Victim of Bullying and Body Image Perception in Adolescents
Authors: Libing Viny , Lerik M. Dinah Charlota , Kiling Indra Yohanes
Published: March 2022

This study aims to determine the relationship between experiences as victims of bullying and the perception of adolescent body image. The hypothesis of this research is that there is a positive relationship between experiences as victims of bullying and the perception of negative body image in adolescents. Participants in this study involved 100 adolescents in Kupang City aged 15-23 years (79 girls and 21 boys) who experienced bullying in the past year. The study used a quantitative approach with a modified Forms of Bullying-Victimization scale and a modified Body Satisfaction scale. Hypothesis testing with the Pearson Product Moment correlation technique shows a correlation coefficient of 0.319* with a significance level of 0.0005 (p <0.01). The results showed that there was a significant positive relationship between experiences as victims of bullying and perception of body image. This study concluded that the higher the level of bullying experienced by the victim, the higher the negative body image perception was.
Relationship Parental Social Support and Subjective Well-Being In Adolescents
Authors: Tefbana Febi Mariana , Lerik M. Dinah Charlota , Damayanti Yeni
Published: March 2022

Abstract. Human beings certainly want happiness in life, because happiness is something important and must be achieved by each individual because it is individual. Subjective well-being is felt and experienced by everyone, including teenagers. Adolescence is a stage of development where individuals undergo a transition from childhood to adulthood. A very important factor in the subjective well-being experienced by adolescents is social support. Social support is a feeling of comfort, attention, and respect that is received by individuals from other individuals or groups. This research is quantitative research, with the method used is a correlation study. The sampling technique is using random stratification with the number of samples in this study as many as 90 people. The subjects in this study were adolescents. Data analysis using Pearson Product Moment correlation test. Test results between social support parents and subjective Well-Being -0.516, there is a positive and significant relationship between the two research variables. The higher the social support of parents felt by teenagers, the higher the subjective well-being in the teenagers of SMA Negeri Banat.