bluuebunny/crossref_metadata_2025 huggingface dataset:
Uji Efek Protektif Madu Hutan (Apis dorsata) Terhadap Ketinggian Vili dan Kedalaman Kripta Duodenum Tikus Jantan Galur Wistar yang Diberi Pajanan Aspirin
Authors: Rahayu Anisa Ulwi
Published: January 2024

Latar belakang: Ulkus peptikum merupakan efek samping utama dari aspirin yang merupakan obat dari golongan NSAIDs. Madu mengandung flavonoid yang memiliki sifat antioksidan yang dapat mencegah dan menghilangkan kerusakan oksidatif. Flavonoid dapat mempertahankan vili dari kerusakan struktur duodenum.

Metode: Penelitian ini merupakan penelitian eksperimental dengan desain post test only-control group. Sampel merupakan bahan biologi tersimpan berupa preparat histologi duodenum tikus yang telah mendapat perlakuan dan dibagi menjadi 5 kelompok: kelompok kontrol normal (KN), kelompok perlakuan I (KP1) (aspirin 400mg/kgBB + madu 1,55ml/kgBB), kelompok perlakuan II (KP2) (aspirin 400mg/kgBB + madu 3,1 ml/kgBB), kontrol positif (K+) (sukralfat 4 ml/kgBB), dan kelompok kontrol negatif (K-) (aspirin 400mg/kgBB). Variabel pada penelitian ini adalah ketinggian vili, kedalaman kripta, dan rasio vili:kripta duodenum, diamati dengan perbesaran lensa objektif 10x. Data dianalisa dengan menggunakan uji ANOVA dan post-hoc test LSD, serta uji Kruskal-Wallis dengan post-hoc test Mann-Whitney.

Hasil: 1) Kelompok tikus yang diberi madu hutan dengan dosis 1,55 ml/kgBB, 3,1 ml/kgBB, dan aspirin memiliki vili yang lebih tinggi, kedalaman kripta yang lebih baik, dan rasio yang lebih baik dibandingkan dengan duodenum tikus yang hanya diberi aspirin.

Kesimpulan: Pemberian madu hutan (Apis dorsata) memberikan efek protektif terhadap duodenum tikus yang diberi pajanan aspirin.
AN UNUSUAL CASE OF PATIENT WITH DILATED CARDIOMYOPATHY SECONDARY TO HYPOTHYROIDISM: A CASE REPORT
Authors: Ketut Angga Aditya Putra Pramana  , Yusra Pintaningrum
Published: January 2024

Background: Alteration in thyroid hormone may affect on the cardiovascular system because the heart is very sensitive to an alteration of thyroid hormone. Alteration in thyroid hormone has been known to cause the changes in cardiac structure and function, such as the development of dilated cardiomyopathy which is a very rare manifestation of hypothyroidism.

Case Illustration: A 26-year-old woman came to a cardiology clinic with a chief complaint of fatigue and breathlesness. On physical examination are unremarkable. On clinical laboratory examinations showed elevated TSH serum levels and decreased FT4 serum levels. On echocardiography, the patient had moderate mitral regurgitation, mild tricuspid regurgitation, all chamber dilatation, and abnormal left ventricular systolic function with ejection fraction 26.9%. The treatment of this patient are levothyroxine 50ug/day, furosemide 40 mg, spironolactone 25 mg, bisoprolol 2.5 mg, ramipril 1.25 mg, and acetylsalicylic acid 80 mg all in once daily.

Discussion: Dilated cardiomyopathy is characterized by enlargement of the ventricular chamber with impaired systolic function. Hypothyroidism is associated with decreased cardiac contractility and decreased cardiac output because of the genomic effect of thyroid hormone to the cardiovascular system is involved in the regulation of mRNA transcription of genes associated with the contractile system.

Conclusions: Hyperthyroidism is often cause dilated cardiomyopathy, but in this case, hypothyroidism also can cause dilated cardiomyopathy. Early diagnosis and management of hypothyroidism are very important to restore the cardiac function.
Effect of Arsenic Contamination in Drinking Water During Pregnancy with the Incidence of Congenital Heart Disease: A Meta-Analysis
Authors: Yusra Pintaningrum  , Akbar Dwi Juliardi  , Romi Ermawan  , Pramana Ketut Angga Aditya Putra
Published: January 2024

Background: Water is a basic human need. The need for clean water continues to increase along with the increasing human population. Drinking water providers are required to provide harmless water. Several studies have discussed the effect of arsenic contamination in drinking water on the incidence of congenital heart disease. Objective: To evaluate the impact of arsenic contamination in drinking water during pregnancy on the incidence of congenital heart disease. Method: Search for published scientific articles using the PRISMA (Preferred Reporting, Items for Systematic Reviews and Meta-Analysis) method conducted on PubMed using the following keywords: “arsenic”, “drinking water” “contamination”, “congenital heart desease”, “congenital heart defect” as the keyword, also combined by using “or” and “and”. Further meta-analysis using Jamovi version 2.2.5 software were performed based on the included published scientific articles. Result: Based on 3 studies included about  effect of arsenic contamination in drinking water during pregnancy with the incidence of congenital heart disease, the analytical results showed a statistically significant positive relationship (z=1.42, p<0.001;95% CI[-0.038;0.240]) but in the low category (r=0.101). Conclusion: Arsenic contamination in drinking water during pregnancy has a low effect on the incidence of congenital heart disease.

Keyword: drinking water, arsenic, congenital heart disease
Skrining Pendengaran Bayi Baru Lahir Dalam Hubungannya Dengan Faktor Risiko Gangguan Dengar di RSUD Provinsi NTB
Authors: Yuliyani Eka Arie
Published: January 2024

Latar belakang: Latar belakang: Salah satu indera yang paling penting dalam perkembangan anak usia dini adalah pendengaran. Gangguan pendengaran pada bayi atau anak dapat berdampak pada keterlambatan perkembangan kognitif, emosional dan komunikasi sosial anak yang dapat mempengaruhi kualitas hidup anak dan orang tua. Oleh karena itu, sangat perlu untuk mengidentifikasi adanya gangguan pendengaran pada bayi melalui program skrining pendengaran menggunakan OAE (Otoacoustic Emission).

Metode: Penelitian ini merupakan penelitian deskriptif retrospektif dan metode pengambilan sampelnya adalah consecutive sampling, kemudian data dianalisis dengan menggunakan uji chi square.

Hasil: Hasil penelitian ini diperoleh hubungan yang signifikan antara usia kehamilan prematur dengan berat badan lahir rendah (BBLR) pada hasil pemeriksaan OAE dengan p=0,017 dan p=0,015.

Kesimpulan: kelahiran prematur dan BBLR secara statistik memiliki hubungan yang signifikan terhadap hasil pemeriksaan OAE. Kedua faktor risiko tersebut merupakan suatu kondisi yang dapat meningkatkan angka kejadain gangguan pendengaran pada bayi baru lahir disamping faktor risiko lainnya
Hubungan Tingkat Stres dengan Tingkat Insomnia pada Mahasiswa Fakultas Kedokteran Universitas Muslim Indonesia
Authors: Fattah Nurfachanti , Zulfahmidah  , Munawara Sobria , Syahril Erlin , Isnaini Arni
Published: January 2024

Latar belakang: Kejadian stres terus meningkat seiring berjalannya waktu, mahasiswa dalam kegiatannya tidak terlepas dengan stres. Apabila seseorang merasakan kecemasan, dan cemas yang lebih bisa menyebabkan gangguan tidur, gangguan tidur yang paling banyak dialami dikalangan mahasiswa adalah insomnia. Studi ini dilakukan berkenaan dengan tingginya angka stres dan insomnia pada mahasiswa Fakultas Kedokteran Universitas Muslim Indonesia. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat stres dengan tingkat insomnia pada mahasiswa Fakultas kedokteran Universitas Muslim Indonesia
Metode : Penelitian ini merupakan penelitian deskriptif analitik dengan desain belah lintang (cross-sectional). Sampel diambil secara total sampling. Pengumpulan data menggunakan kuesioner Depression Axiety Stress Scale (DASS) dan kuesioner Kelompok Studi Psikiatri Biologik Jakarta- Insomnia Rating Scale (KSPBJ-IRS). Penelitian ini berlangsung pada bulan Desember 2021- Januari 2022.
Hasil : Berdasarkan hasil penelitian dari 527 responden terdapat 254 atau 42,8% orang normal (tidak stres), 69 atau 12,1% stres ringan, 112 atau 19,6% stres sedang, 66 atau 11,5% stres berat, dan 80 atau 14,0% mengalami stres sangat berat. Sedangkan untuk insomnia terdapat 161 atau 28,1% responden tidak ada keluhan insomnia, 257 atau 44,9% mengalami insomnia ringan, 134 atau 23,4% insomnia sedang, 20 atau 3,5% responden mengakami insomnia berat. Dari hasil uji korelasi didapatkan hasil hubungan positif kuat  ditandai dengan nilai signifikan p < 0.000 dan r = 0.706, karena nilai p <0,005 dan nilai r positif dan terletak antara 0.60-0.799.
Kesimpulan : ada hubungan bermakna antara tingkat stres dengan tingkat insomnia pada mahasiswa Fakultas Kedokteran Angkatan 2018, 2019, dan 2020 Universitas Muslim Indonesia
Uji Aktivitas Anti-Inflamasi Infusa Bunga Pukul Empat (Mirabilis jalapa L.) secara In Vivo
Authors: Handayani Ervina , Hasina Raisya , Zakiah Melda Putri , Suryani Bunga , Erlangga Ithnan Baqi Putra , Radiartini Ni Nyoman
Published: January 2024

Latar belakang: Prevalensi penyakit inflamasi di Indonesia cukup tinggi dapat ditandai dengan rasa nyeri pada sendi hingga mengalami infeksi pada saluran pencernaan. Bunga pukul empat (Mirabilis jalapa L.) memiliki aktivitas farmakologi sebagai antiinflamasi. Rebusan dari simplisia bunga pukul empat telah dimanfaatkan oleh masyarakat sebagai anti radang secara tradisional. Hasil skrining fitokimia bunga pukul empat menujukkan bahwa senyawa flavonoid yang terkandung didalamnya diketahui memiliki peran dalam aktivitas antiinflamasi yang dapat menghambat enzim siklooksigenase.

Metode: Penelitian ini menggunakan desain eksperimental skala laboratorium menggunakan kelompok hewan uji terdiri dari kontrol negatif yang diberikan suspensi natrium karboksimetil selulosa  0,5%, kontrol uji infusa bunga pukul empat 5% dan 10%, serta kontrol positif  menggunakan suspensi natrium diklofenak dosis 6,5 mg/kg BB. Pembentukan inflamasi pada kaki mencit jantan dilakukan secara intraplantar dengan volume induksi sebanyak 0,1mL. Volume edema diukur setiap 15 menit selama 3 jam menggunakan alat pletismometer.

Hasil: Data hasil diperoleh berbeda bermakna antara kontrol negatif dengan kontrol uji lainnya yang ditunjukkan pada waktu 3 jam dimana kontrol positif (suspensi natrium diklofenak dosis 6,5 mg/kg BB) dan kontrol uji (infusa bunga pukul empat 5% dan 10%) mengalami penurunan yang sama.  

Kesimpulan: Infusa bunga pukul empat (Mirabilis jalapa L.) memiliki efek sebagai antiinflamasi.
Omega-3 Memiliki Banyak Manfaat: Apakah Bisa Melawan Kanker?
Authors: Rudia Ahda Fatikha , Dwi Hendriani Aulia , Amelia Negara Baiq Ramdhani , Atifah Radwa Ghanniya , Nurhidayati
Published: January 2024

Abstract: Cancer is the biggest cause of death in the world, around 10 million deaths are caused by cancer. In 2020, 17 million new cases were recorded, of which 8.5 million people died each year from cancer, while 66% of patients can live up to 5 years after being diagnosed and 40% of patients can live more than 10 years after being diagnosed. Various prevention efforts against risk factors have been carried out. The main modalities of cancer therapy today are surgery, chemotherapy, and radiation with the choice of therapy based on the stage of the cancer. Research shows that giving omega-3 supplementation to patients undergoing chemotherapy is considered very beneficial because omega-3 works synergistically with chemotherapeutic agents and can also be used to increase the radiosensitivity of tumor cells so that it has a good impact on the success of therapy.
Aktivitas Antibakteri Senyawa Fenolik dari Fraksi Kulit Buah Kopi Robusta (Coffea canephora L.)
Authors: Citra Dewi Nabila Putri Kusuma , Agriana Rosmalina Hidayati  , Nisa Isneni Hanifa
Published: January 2024

Kulit buah kopi mengandung senyawa golongan fenolik yang memiliki efek biologis khususnya sebagai antibakteri. Kulit buah kopi diekstraksi dan kemudian difraksinasi menggunakan akuades dan etil asetat. Analisis kualitatif dilakukan dengan Uji Tabung dan Kromatografi Lapis Tipis  (KLT). Pengujian aktivitas antibakteri mengguankan metode difusi cakram dengan kelompok perlakuan kontrol positif (Kloramfenikol 1%), kontrol negative (DMSO 10%), ekstrak etanol (konsentrasi 20; 30; dan 40%), fraksi air (konsentrasi 2; 3; dan 4%), dan fraksi etil asetat (konsentrasi 2; 3; dan 4%). Analisis hasil dilakukan dengan SPSS menggunakan Kruskall-Wallis dan Mann-Whitney. Hasil pengujian analisis kualitatif menunjukkan bahwa ekstrak, fraksi air, dan fraksi etil asetat mengandung senyawa fenolik. Pada pengujiam dengan KLT didapatkan hasil bahwa terdapat bercak noda pada senyawa ekstrak etanol dan fraksi etil asetat yang menunjukkan bahwa terdapat kandungan senyawa yang sama diantara keduanya. Pengujian antibakteri ekstrak dan fraksi etil asetat menghambat pertumbuhan bakteri S.aureus, sedangkan hanya ekstrak 40% dan fraksi etil asetat yang mampu menghambat pertumbuhan bakteri E.coli. Fraksi air tidak dapat menghambat pertumbuhan bakteri S.aureus dan E.coli. Ekstrak etanol dan fraksi etil asetat kulit buah kopi robusta berpotensi sebagai kandidat antibakteri
post stroke epilepsy : case report
Authors: Solihatul Fitri Sani , Safat Wahyudi
Published: January 2024

Abstract: Post-stroke seizures is a common complication in post-stroke patients, it is reported that about 8-15 % of cases may develop into post-stroke epilepsy. A 54-year-old man was referred from Primary Health Care with a complaint of seizures on the right side of the body for more than 30 minutes. Seizures have often occurred since last year after the patient had a stroke attack. The patient has had 2 strokes attack in 2021 and 2022. The seizure stopped right before the patient arrived in the emergency room. The patient experienced weakness on the right side of the body and was unable to speak since his 1st stroke attack. When the patient was transferred to the neurology ward, he experienced another seizures, the duration of seizure < 2 minutes, with the frequency >3 times, the patient remained conscious during the event. We give phenytoin 100 mg/8 hours. Head CT in 2022 shows an infarction in the middle cerebral artery. Brain ischemia causes damage to neurons which causes an imbalance between inhibitory neurons and excitatory neurons which causes seizures. Seizures in post-stroke patients are divided into early-onset and late-onset seizures. Male stroke patients aged <65 years with history of hypertension, history of stroke involving the territorial MCA have a higher risk of developing Post Stroke Epilepsy (PSE). The patient in this case has a high risk of experiencing PSE because his past stroke involving the territorial MCA, besides that there is history of uncontrolled hypertension and age < 65 years.
Pengaruh Ekstrak Buah Bakau terhadap Infiltrasi Sel Radang pada Hati Tikus yang Diberi Diet Tinggi Lemak
Authors: Hamidy Muhammad Yulis , Rangkuti Ina Farida , Masdar Huriatul , Adila Adinda Fitri , Baihaqi Faizul
Published: January 2024

Liver disorders are health problem that needs attention because of its high incidence and cause of morbidity and mortality with various complications. Liver disorders can be treated by hepatoprotective drugs. One of plants that is expected to be developed is mangroves. The antioxidant effect possessed by mangroves can be developed as hepatoprotector. This study aims to assess the effect of mangrove fruit extract on infiltration of inflammatory cells in livers of rats receiving a high-fat diet. 24 male Rattus norvegicus rats were divided into 4 groups, Group 1 was negative control group which was given a normal diet, Group 2 was positive control group which received a high fat diet, Group 3 received a high fat diet and Rhizophora sp fruit extract 500 mg/kgBB, and Group 4 received a high-fat diet and Sonneratia alba fruit extract 400 mg/kgBB. The infiltration of inflammatory cells in the liver of rat was examined using hematoxylin eosin staining. The results showed that average number of inflammatory cells in Group 1 was 13 cells, Group 2 was 63 cells, Group 3 was 16 cells and Group 4 was 20 cells. These results indicate that administration of a high-fat diet increases the infiltration of inflammatory cells in liver of rat, while administration of mangrove fruit extracts from both Rhizophora sp and Sonneratia alba can inhibit the increase in infiltration of inflammatory cells. In conclusion, mangrove fruit extract has potential to provide a protective effect on liver of rat receiving a high-fat diet.
PENGARUH SISTEM INFORMASI PENGELOLAAN KEUANGAN DAERAH TERHADAP EFEKTIVITAS PENGELOLAAN KEUANGAN PEMERINTAH DAERAH
Authors: M. Wisnu Pratommi  , Muhsyaf Saipul Arni , Isnawati
Published: January 2024

Penelitian ini bertujuan untuk memgetahui pengaruh sistem informasi pengelolaan keuangan daerah terhadap efektivitas pengelolaan keuangan daerah pada Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Lombok Tengah. Jenis penelitian ini adalah penelitian kuantitatif deskriptif dengan pendekatan kausalitas. Metode pengumpulan data dalam peneltiian ini menggunakan kuesioner. Jumlah sampel dalam penelitian ini adalah 40 pegawai yang bekerja di Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Lombok Tengah. Alat untuk menganalisis dalam penelitian ini menggunakan Partial Least Square (PLS). Hasil penelitian ini menunjukan bahwa sistem informasi pengelolaan keuangan berpengaruh signifikan terhadap efektivitas pengelolaan keuangan daerah. Hal ini dibuktikan dengan nilai p value yang lebih kecil dari 0,05 (0,05>0,000).
IMPACT AND IMPORTANCE, FOR BRAZIL, OF EIGHT THEMATIC REPORTS OF THE UN SPECIAL RAPPORTEUR ON TORTURE
Authors: Napoleão Alves Henrique
Published: January 2024

La Relatoría Especial de las Naciones Unidas sobre la Tortura ha aprobado ocho informes temáticos sobre el uso de fuerza; migración; reafirmación de la prohibición de la tortura; corrupción; violencia doméstica; tortura psicológica; factores biopsicosociales; y cooperación de los Estados con la Relatoría. En 2021, el Relator solicitó aportes sobre el impacto de los informes y su relevancia en el contexto nacional. Este artículo es la respuesta a la solicitud del Relator con respecto a Brasil, a partir de una entrevista a una especialista en prevención de la tortura, además de investigación teórica de la literatura especializada, legislación, jurisprudencia, notas de prensa e informes de organizaciones internacionales. Por sus características, puede ser de interés para académicos-as, juristas prácticos/as y agentes públicos comprometidos con temas de derechos humanos y estudios sociales sobre Brasil.
Translanguaging Pedagogies in an ESP Course: A Case in Indonesia
Authors: Triastuti Aan , Nurkamto Joko , Sumardi Sumardi
Published: January 2024

This study investigates into the implementation of translanguaging pedagogy within Indonesian English for Specific Purposes (ESP) classrooms. In Indonesia, where multilingualism is prevalent, there is a growing trend to integrate local languages, such as Indonesian and Javanese, into educational contexts. This approach, which values and purposefully employs students' first languages (L1s), has been increasingly adopted by teachers. The research aims to explore Indonesian ESP teachers' perspectives on translanguaging and its application in their teaching practices. Through a qualitative case study, this paper examines how translanguaging facilitates communication, enhances teacher-student relationships, and aids in the processing of educational material. It also investigates potential resistance to monolingual pedagogies and the constructive use of translanguaging to further educational objectives. Data were gathered via semi-structured interviews with five ESP teachers and through classroom observations. The findings highlight the positive role of translanguaging in education. Teachers reported that translanguaging aids in knowledge construction, boosts vocabulary comprehension, strengthens interactions between teachers and students, and fosters a comfortable and engaging learning environment. These insights underline the importance of developing translingual strategies, encouraging teachers to incorporate students’ complete linguistic repertoire in their teaching. This approach not only facilitates English language learning but also acknowledges and leverages the linguistic diversity in Indonesian classrooms.
Challenges and Strategies in Teaching English Speaking Skills to Young Learners: Perspectives of Teachers in Indonesia
Authors: Laila Fitri Nur , Adityarini Hepy , Maryadi Maryadi
Published: January 2024

This research explores the challenges and strategies associated with teaching English speaking skills to young learners in Indonesia, focusing on students learning English as a second or foreign language. The study aims to understand the specific obstacles faced by teachers in this context and to identify effective methods for overcoming these challenges. Employing a qualitative case study approach, the research involved five elementary English teachers selected through purposive sampling. Data collection was conducted through interviews and observations, followed by thematic analysis to interpret the findings. The study also emphasized ensuring data quality through the establishment of trustworthiness. The findings revealed five key issues impacting the teaching of English-speaking skills to young learners in Indonesia. Challenges stemming from the students included inhibition, negative attitudes towards learning English, and low participation rates. From the teachers' perspective, difficulties in classroom management and the lack of a supportive English learning environment were identified as significant obstacles. To address these challenges, the teachers employed various strategies, including individualized instruction, use of translation, repetition techniques, and integrating games into the learning process. These approaches aimed to enhance student engagement and facilitate a more effective learning environment for developing English speaking abilities in young learners. The study's insights contribute to a better understanding of the complexities involved in teaching English as a second language in the Indonesian educational setting and offer practical solutions for educators facing similar challenges.
Returning to the Classroom: A Narrative Inquiry into the Challenges and Coping Strategies of an EFL Teacher Resuming After Hiatus
Authors: Romadhon M.Galuh Elga , Mustofa Mutmainnah , Elfiyanto Sonny , Rifyani Andri Jamaul
Published: January 2024

This qualitative study employs narrative inquiry to investigate the challenges and coping strategies of T1, an EFL teacher at an Islamic private elementary school, returning to teaching after a hiatus. Through unstructured interviews, it examines the changes in T1's teaching approach before and after the break, uncovering unique challenges and adaptive strategies. The research reveals T1's struggle with readjustment, curriculum changes, and lesson planning without standard textbooks. To navigate these challenges, T1 utilized familial support, embraced technological resources for professional growth, and innovatively combined traditional and modern teaching methods. These findings emphasize the importance of continuous professional development, adaptability, and robust support systems in enhancing the reintegration process for EFL teachers. The study contributes valuable insights into the EFL field, highlighting the need for resources and strategies to support teachers like T1 in transitioning back to the classroom. This research not only sheds light on the specific challenges faced by returning EFL teachers but also underscores the critical role of support systems and professional development in maintaining high-quality EFL education.
Developing an English Language School Management Course: Curriculum Innovation and Entrepreneurial Opportunities at Universitas Negeri Makassar
Authors: Korompot Chairil Anwar , Fauzan Muhammad Miftah , Nur Sahril
Published: January 2024

This paper is based on a systematic literature review conducted to justify the introduction of a new course, 'English Language School Management' (ELSM), in the English Language Education Study Program (ELESP) at Universitas Negeri Makassar, Indonesia. The literature review involved a detailed analysis of academic sources relevant to English language education and management, identifying gaps in current academic discourse and practical educational needs in the post-Covid-19 context. Prompted by the implementation of the Merdeka Belajar Kampus Merdeka program, which necessitated curriculum revision, ELSM was developed. This course aims to provide ELESP students with critical insights into the operation and management of English language schools. These institutions are vital in non-formal education, as underutilized partners in teacher training programs, and as potential employment and entrepreneurial opportunities for graduates. The introduction of ELSM addresses a notable lack of focus on English language schools within Indonesian academic circles, despite their popularity and significant educational contributions. The development of this course is expected to enhance ELESP students' awareness of both the potential and challenges faced by English language schools, especially in the post-pandemic era.
Introduction: John Lachs's Philosophical Pluralism
Authors: Ritter Eric
Published: January 2024

Abstract: A brief introduction to the papers presented at a conference held at Vanderbilt University in the Fall of 2023, called "John Lachs and American Philosophy," organized by the Philosophy Department and the College of Arts and Sciences. The symposium includes papers by Herman Saatkamp, John Stuhr, Eric Weber, and Chris Skowroński. It is followed by a response from John Lachs written down by Michael Hodges based on conversations.
Pluralism, Individualism, Mediation and Their Discontents: John Lachs's Pragmatism
Authors: Stuhr John J.
Published: January 2024

Abstract: This essay places the writings of John Lachs in the tradition of classical American philosophy through an appreciative and critical analysis of several central ideas: pluralism, individualism, mediation, meddling, the cost of comfort, and Stoic pragmatism. I focus on the need to move pluralism from the conceptual to practical realm, and on the need for a less self-contained, libertarian, and ultimately Romantic form of individualism. I also stress the importance of viewing philosophies as personal expressions of temperament.
Use Of Micronized Calcium Carbonate-Based Sunscreen on Young European Hazelnut (Corylus Avellana L.) in Commercial Nursery Under Environmental Stress Conditions During the Summer Period
Authors: Montanares Ignacio Errazuriz , Fernandez Sergio , Cañete-Salinas Paulo , Ogass Khristopher , Espinosa Cristian , Guajardo Jorge , Saavedra Nicolas , Contreras Sebastián , Zamudio Francisco , Opazo César Acevedo
Published: January 2024

Chile has become one of the main exporters of European hazelnuts in the world, mainly due to favorable edaphoclimatic conditions. Currently, due to the negative effects of climate change, ​​Chile has been suffering recurrent heat waves and droughts, which are damaging the productive efficiency of the European hazelnut. The present research proposes to evaluate the use of a sunscreen composed of micronized calcium carbonate, pinolene and lignosulfonate on young European hazelnut plants growing in a commercial nursery. In this study, the environmental conditions of heat stress observed during the summer months were evaluated. The results show statistically significant differences between treatments, in favor of plants treated with the sunscreen in at least one of the three months of evaluation. Thus, stomatal conductance (gs) showed increases of up to 29% compared to the control treatment, transpiration rate (Tr) increased by up to 25% and the net assimilation rate (an) increased by up to 18% compared to the control treatment without application. The use of sunscreen would increase the gas exchange of young European hazelnut plants, thus providing greater tolerance to conditions of high environmental temperature, promoting an increase in the production of photo-assimilates compared to untreated plants.
Stability analysis and genotype X environment interaction of cotton seed and fiber yield of some cotton (Gossypium hirsutum L.) genotypes in multi-environment in Mali
Authors: Sory Sissoko  , Mamadou Oumar Diawara  , Elhadji Mamoudou Kassambara  , Mariam Traoré  , Gassiré Bayoko  , Daouda Seydou Maiga
Published: January 2024

Cotton is a strategically important crop for Mali. Mainly used for export, it represents 50–60 % of the value of the country's exports. Genotype by environment interaction study was carried out to identify the most stable cotton genotype(s) and the most desirable for seed cotton yield and lint yield in 35 villages across six different environments(High Valley of the Niger, New Cotton Growing Zone, North Sudan-Sahel, Old Basin, Southern Extension Zone and Zone Sikasso-Bougouni) in a dispersed block design. Where each village represented a block, giving a total of 35 blocks or replications. A combined analysis of variance showed that yields of seed cotton and fiber were significantly affected by environments (p<0.05), but did not reveal any significant difference between genotypes or genotype-environment interactions. The result of GGE biplot analysis method showed that the polygonal view identified three mega-environments (ME1, ME2 and ME3) with three winning genotypes: BRS 293, NTA B149 and NTA L66, respectively, for seed cotton yield. For fiber yield, the winning genotypes were CG1, NTA L65 and BRS 293, respectively. Given that all the varieties tested have a mean fiber yield within the recommended norms, the two promising varieties NTA B149 and NTA L66 with good seed cotton yields and the standard check BRS 293 can be recommended for extension in the environments to which they have been assigned.
In silico approach of 2,5-Diketopiperazines from marine organisms to neurodegenerative diseases
Authors: Rodrigo Chico-Merino  , Antonio Rosales-López  , Joel L. Terán  , Alan Carrasco-Carballo
Published: January 2024

In this paper we present an in silico studies of new biological active of 2,5-Diketopiperazines candidates, from Marine Organisms to neurodegenerative diseases particular for the neurodegenerative central nervous system to Alzheimer's, Huntington and Parkinson’s diseases. A total of 35 DKPs were studied, by structural similarity analysis obtained MAO-A/B, β/γ-Secretase, COX-1/2 enzymes targets obtained, to continue molecular docking studies compared to endogenous substrates and reference inhibitors, finding a multitarget potential to increase dopamine levels and decrease β-amyloid and PGE2 levels, which makes them excellent molecules for studies against neurodegenerative diseases. DKP4, DKP23 and DKP25 as inhibitors of the 6 enzymes and DKP15, DKP19, DKP21, DKP26 and DKP33 for β-Secretease specifically, the rest with multitarget potential, denoting that the DKP ring serves as a base to generate multitarget or unitarget compounds through modifications in substituents. Finally, DKPs present low bioaccumulation in the body, no toxicity, high feasibility of crossing hematoencephalic membrane and activity on the CNS, which makes them an interesting set of molecules for the search for alternatives against neurodegenerative diseases.
Hubungan Pengetahuan Dengan Sikap Dalam Menghadapi Menarche Pada Anak Kelas V
Authors: 'ah Hani , Ismarwati Ismarwati
Published: January 2024

Menarche merupakan menstruasi pertama kali yang dialami oleh perempuan. Secara nasional rata-rata usia menarche 12 tahun dan ada juga yang baru berusia 9 tahun sudah memulai siklus haid namun jumlah ini sedikit sekali. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dengan sikap dalam menghadapi menarche pada anak kelas V di SDN Mejing 2 Gamping. Penelitian ini berupa penelitian kuantitatif menggunakan metode analitik cross sectional dengan data primer menggunakan kuesioner. Populasi sebanyak 33 responden dengan teknik pengambilan sampel menggunakan total sampling. Hasil penelitian sebagian besar pengetahuan tentang menarche baik (54,6%) dan sebagian besar sikap negative (51,6%) sehingga tidak ada hubungan yang signifikan antara pengetahuan dengan sikap dalam menghadapi menarche pada anak kelas V di SDN Mejing 2 Gamping Sleman Yogyakarta. Analisis uji statistik menggunakan chi-square dengan p-value (0,373) atau disebut >0,05.
Hubungan Pengetahuan Dan Sikap Akseptor KB Dengan Penggunaan Pil Kombinasi Di Puskesmas Kepi
Authors: Pasulu Ludia Raya , Yuliati Luluk , Wijayanti Irfana Tri
Published: January 2024

Memahami pengetahuan yang dimiliki akseptor KB dan sikap mereka terhadap kontrasepsi pil kombinasi dapat membantu identifikasi potensi kesalahpahaman atau kurangnya informasi mengenai risiko dan efek samping. Ini penting untuk meningkatkan keselamatan dan keberlanjutan penggunaan kontrasepsi ini. Penelitian ini dilakukan untuk mengetahui hubungan pengetahuan dan sikap akseptor KB dengan penggunan kontrasepsi pil kombinasi di Puskesmas Kepi Papua Selatan.Penelitian ini menggunakan desain observasional analitik dengan desain cross sectional. Populasi dalam penelitian ini adalah seluruh ibu akseptor selama bulan April-Juni 2023, dengan teknik sampling total sampling maka jumlah sampel yang digunakan adalah 40 responden. Instrumen yang digunakan adalah kuesioner pengetahuan dan sikap. Analisis hubungan bivariat dengan uji Chi Square.Hasil penelitian menunjukkan bahwa: 21 orang (52,5%) memiliki pengetahuan yang baik tentang kontrasepsi pil kombinasi, 22 orang (52,5%) memiliki sikap positif terhadap penggunaan kontrasepsi pil kombinasi, 18 orang (45,0%) menggunakan kontrasepsi pil kombinasi. Hasil analisis bivariat menunjukkan ada hubungan pengetahuan tentang kontrasepsi pil dengan penggunaan KB pil  (p= 0,004), dan ada hubungan sikap akseptor KB dengan penggunaan KB pil di Puskesmas Kepi Papua Selatan (p= 0,009). Pengetahuan dan sikap positif terhadap Pil kombinasi, membuat ibu memiliki kesempatan untuk membuat keputusan yang tepat tentang rencana kehamilan mereka dan mendapatkan kesehatan reproduksi yang lebih baik.
Pengaruh Penyuluhan Dismenore Terhadap Perilaku Penanganan Dismenore Pada Remaja Putri Di Kelurahan Gending Gresik
Authors: Handajani Diani Octaviyanti , Munisah Munisah
Published: January 2024

Latar Belakang : Kesehatan reproduksi pada remaja adalah suatu keadaan yang menggambarkan kondisi yang sehat pada remaja putri yang terdiri dari sistem, fungsi dan proses reproduksi yang normal dan baik. Sebagai sorang perempuan,  mempunyai tugas yang cukup berat, yaitu harus menjaga keturunannya untuk lahir dalam kondisi sehat, maka remaja putri harus menjaga pola seksual yang sehat dan seluruh aspek yang berhubungan dengan kesehatan reproduksinya. Metode: desain penelitian quasi eksperimen. Jenis penelitian ini menggunakan rancangan One group pretest-posttest. Populasi penelitian ini adalah remaja putri yang berada di Kelurahan Gending Gresik. Tehnik pengambilan sampel yang digunakan purposive sampling dan jumlah sampel adalah 49 orang. Penelitian ini memakai  uji Wilcoxon Siqned Rank Test. Hasil : perilaku remaja putri dalam penanganan disminorea sebelum penyuluhan didapatkan standar deviasi 3,258 yang nilai rata-ratanya sebesar 80,27, sedangkan perilaku penanganan dismenorea setelah penyuluhan mempunyai rata-rata 82,65 dengan standar deviasi 3,263. Hasil ini menunjukkan penyuluhan dapat meningkatkan perilaku penanganan dismenorea. Hasil uji  Wilcoxon Signed Rank Test diperoleh  Asymp.Sig.(2-tailed) (p-value) sebesar 0,000. Kesimpulan : bahwa ada pengaruh penyuluhan dismenore terhadap perilaku penanganan dismenore pada remaja putri.
Hubungan Status Gizi Dan Kelengkapan Imunisasi Dengan Kejadian ISPA Pada Balita
Authors: Wijiastutik Vivin , Nikmah Nurun
Published: January 2024

Infeksi Saluran Pernapasan Akut atau disingkat ISPAadalah masalah yang seringkali terjadi terutama di negara-negara berkembang.Beberapa faktor predisposisi ISPA seperti perilaku, status gizi, dan status imunisasi anak. Penelitian ini dilakukan untuk menganalisis hubungan status gizi dan kelengkapan imunisasi dengan kejadian ISPA pada balita. Penelitian ini menggunakan metode analitik dengan rancangan penelitian studi cross sectional. Variabel independen pada penelitian ini adalah Status gizi dan kelengkapan imunisasi, sedangkan Variabel dependen pada penelitian ini adalah ISPA (Infeksi Saluran Pernapasan Akut) pada Balita. Populasi dari penelitian ini adalah balita di Desa Jaddih berjumlah 64 balita, sampel 55 balita dengan menggunakan teknik simpel random sampling. Uji statistik pada penelitian ini menggunakan Chi-Square dengan α=0,05.Pada penelitian ini didapatkan hubungan status gizi balita dengan ISPA yang bermakna secara statistik (p-value 0,000 < 0,05), sedangkan hubungan kelengkapan imunisasi juga menunjukkan hubungan bermakna dengan p value 0,000 < α=0,05. Oleh karena itu, penurunan faktor risiko seperti status gizi dan imunisasi perlu dilakukan modifikasi dengan cara melakukan pendidikan kesehatan kepada ibu balita demi mengurangi kejadian ISPA.
Pelatihan dan Simulasi Penggunaan Alat Pemadam Api Ringan (APAR) pada Asrama Mahasiswa Kampus XYZ
Authors: Setiowati Noni Oktiana , Teo Lukmanul Hakim  , Mayati Isabella  , Arief Hidayat  , Eka Krisna Santoso  , Muhamad Imron Zamzani
Published: January 2024

Potensi kebakaran dapat terjadi dimana saja terutama tempat tinggal termasuk asrama mahasiswa. Asrama mahasiswa kampus XYZ merupakan bangunan gedung bertingkat tiga lantai yang dihuni oleh 89 orang mahasiswa. Salah satu media yang digunakan untuk memadamkan api tingkat awal adalah Alat Pemadam Api Ringan (APAR). Latar belakang kegiatan pengabdian masyarakat ini adalah terdapat potensi kebakaran pada asrama mahasiswa XYZ yang memiliki dapur serta mahasiswa yang tidak memiliki pengalaman dalam menggunakan APAR. Tujuan pada kegiatan ini adalah mahasiswa mampu memahami cara penggunaan APAR dengan melakukan simulasi dan pelatihan.  Hasil kuisioner pada seluruh peserta berjumlah 15 orang mahasiswa menunjukkan bahwa 100% peserta memahami cara efektif memadamkan api dan menggunakan APAR. Selain itu 93,3% peserta akan menggunakan APAR untuk memadamkan api apabila terjadi kebakaran di masa yang akan datang.
Penguatan Sadar Hukum Atas Pembuatan Serifikat Untuk Mengatasi Sengketa Pertanahan Di Kabupaten Badung
Authors: Yoga I Gede Permana Aditya , Kurniawan I Gede Agus
Published: January 2024

Kesadaran hukum dapat diartikan sebagai kesadaran seseorang atau suatu masyarakat kepada aturan aturan atau hukum yang berlaku. Kesadaran hukum sangat diperlukan oleh suatu masyarakat. Hal ini bertujuan agar tidak terjadinya konflik antar pihak ataupun kelompok. Dalam hal ini khususnya pendaftaran tanah telah dipermudah oleh pemerintah dengan memberikan upaya pendafataran tanah lewat online sehingga Masyarakat tidak perlu datang ke kantor pertanahan. Hasil dari kegiatan pengabdian ini diharapkan Masyarakat mampu untuk meningkatkan kesadaran terkait pendaftaran sertifikat yang telah dipermudah oleh Kantor Pertanahan Kabupaten Badung  supaya mencegah terjadinya sengketa di kemudian hari. Salah satu upaya penyelesaian sengketa yang dilakukan oleh BPN adalah dengan cara mediasi. Dalam penyelesaian konflik tanah, BPN telah mengacu pada Peraturan Menteri Agraria Dan Tata Ruang/ Kepala Badan Pertanahan Nasional Nomor 11 Tahun 2016 tentang Penyelesaian Kasus Pertanahan.
Pengolahan Bunga Telang Kering Dan Sirup Bunga Telang Warga Sekitar Pondok Pesantren Cepokolimo Pacet Mojokerto
Authors: Rahayuningsih Tri , Revitriani Marina , Noerhartati Endang , Mujianto
Published: January 2024

Pondok Pesantren Cepokolimo terletak di Dusun Cepokolimo Pacet Mojokerto yang memiliki udara dingin, pemandangan yang indah berdekatan dengan hutan pinus. Hal ini merupakan sebuah potensi dijadikan sebagai destinasi wisata. Untuk memenuhi kebutuhan oleh-oleh para wisatawan perlu disiapkan produk unggulan. Bunga telang kering dan sirup bunga telang bisa dipersiapkan untuk produk khas yang dimaksud.  Bunga telang mudah ditanam di segala kondisi cuaca dan tempat,  sehingga mudah dibudidayakan. Selain itu salah satu visi misi pondok pesantren adalah memberdayakan dan mengangkat perekonomian masyarakat sekitar.. Pelatihan pengolahan bunga telang kering dan sirup bunga telang selaras dengan visi misi mitra. Tujuan pengabdian masyarakat adalah untuk melatih masyarakat sekitar pondok pesantren agar bisa mengolah bunga telang segar menjadi bunga telang kering dan sirup. Peserta pelatihan diikuti oleh ibu-ibu yang bertempat tinggal di sekitar Pondok Pesantren Cepokolimo. Pelatihan terdiri dari penyampain materi dan praktek. Seluruh peserta pelatihan sudah mengenal bunga telang namun belum tahu khasiat manfaat serta teknologi pengolahannya. Pertanyaan-pertanyaan yang diajukan kritis dan berbobot menunjukkan peserta pelatihan antusias dan tertarik dengan materi yang dipaparkan. Peserta puas dengan penjelasan dari pemateri. Selain itu mereka yakin bisa mempraktekkan sendiri pengolahan bunga telang kering dan sirup bunga telang kering.
Penguasaan Penulis terhadap Kaidah Penggunaan Imbuhan ber- dalam Kajian Sastra Publikasi
Authors: Anifiah Zulfa Lilis , Khasanah Uswatun
Published: January 2024

ABSTRAK: Ber- sebagai salah satu imbuhan tentunya mempunyai aturan tersendiri dalam penggunaannya. Oleh karena itu, artikel ini membahas permasalahan imbuhan dalam ranah penguasaan penulis terhadap kaidah penggunaan imbuhan ber- dalam karya ilmiah berupa reviu kajian literatur. Karya ilmiah yang dijadikan objek penelitian adalah dua artikel kajian sastra terbitan tahun 2018 dan 2020. Kajian pustaka tahun 2018 ini ditulis Jumani dengan judul Struktur dan Nilai Moral Pantun dalam Rubik Bujang Besaot dan Pemanfaatannya sebagai Bahan Ajar di SMA (Jurnal Sirok Bastra, Vol. Sirok Bastra, Vol 6, No. 1, Juni 2018). Kajian Sastra Tahun 2020 ditulis oleh Tisa, dkk, dengan judul Kajian Sosiologi Sastra dalam Langkah Arah Novel Fiersa Besari (Jurnal Samudra Bahasa, Vol. 3, No. 1, Juni 2020). Berdasarkan reviu kedua artikel tersebut, penguasaan penulis terhadap prinsip penggunaan isi ulang belum sempurna. Hal ini dibuktikan dengan adanya kesalahan penggunaan afiks yang diikuti kata dasar yang diawali dengan fonem /r/ dan mengandung bunyi /-er/ pada suku kata pertama.
Kata Kunci: afiks ber-, penguasaan penulis
DMT for Improving Emotional Regulation and Interaction in Adolescents with Autism Spectrum Disorder
Authors:   Korea Dance Movement Psychotherapy Association, Yoon Jung-Ah
Published: January 2024

This research aims to analyze the effects of DMT(Dance , Movement Therapy) on emotional regulation and interaction in adolescents with Autism Spectrum Disorder(ASD). The program consisted of 12 sessions, each lasting 60 minutes and conducted weekly. The research utilized video recordings of each sesstions, House-Tree-Person (HTP) test, Laban Movement Analysis (LMA) and inter-observer agreement to accumulate qualitative case study data through in-depth discussions and journals. The research findings inditcate that, following the DMT program, there were improvements in emotional regulation among adolescents with ASD. Firstly, changes in repetitive movements and expqanstion processes led to a decrease in anger, anxiety and excitement in psychological emotional regulation. Additionally, increased self-confidence in behavior and reduced anxiety towards new spaces were observed. Secondly, immature emotional regulation manifested as impulsive disruptive behavior, aggressive behavior, and repetitive behavior showed a decrease. In terms of interation among adolescents with ASD, the results showed stable improvements in voluntary and proactive participation with relational and social peer relationships. It is hoped that the results of this study will contribute to individualized research for individuals with ASD, and future research on ASD across various age groups is anticipated to continue.
Lopinavir/ritonavir for the treatment of COVID-19: A living systematic review protocol
Authors: F Verdugo-Paiva , A Izcovich , M Ragusa , G Rada
Published: January 2024

Objective
To assess the efficacy and safety of lopinavir/ritonavir for the treatment of patients with COVID-19.
Design
This is the protocol of a living systematic review.
Data sources
We will conduct searches in the [https://app.iloveevidence.com/loves/5e6fdb9669c00e4ac072701d](L.OVE platform for COVID-19), a system that maps PICO questions to a repository maintained through regular searches in electronic databases, preprint servers, trial registries and other resources relevant to COVID-19. No date or language restrictions will be applied.
Eligibility criteria for selecting studies and methods
We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question.
We will include randomised trials evaluating the effect of lopinavir/ritonavir— as monotherapy or in combination with other drugs — versus placebo or no treatment in patients with COVID-19. Randomised trials evaluating lopinavir/ritonavir in infections caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes.
Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome.
A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.
Ethics and dissemination
No ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.
PROSPERO Registration
[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=179212](CRD42020179212)
Keywords
COVID-19, severe acute respiratory syndrome coronavirus 2, Coronavirus Infections, Systematic review, lopinavir, lopinavir/ritonavir, antivirals
SYSTEMATIZATION OF SCIENTIFIC CONCEPTS AND THEORIES OF THE FORMATION OF CLUSTER-UNITED ENTERPRISES
Authors: Shkoda Мariana , Onofriichuk Yana
Published: January 2024

The purpose of the article is research and systematization of scientific concepts and theories regarding the formation of cluster-united enterprises.

Research methods. In this study, when carrying out the systematization of scientific concepts and theories, the authors used general scientific research methods, in particular, to reveal the evolutionary foundations of the development of cluster theory, comparative analysis of scientific concepts of both foreign and domestic scientists regarding the development of cluster formations, the formation of cluster-united enterprises, the following empirical methods were used as a method of historical analysis, methods of logical and comparative analysis.

Presentation of the main research material. In the course of research and systematization of scientific concepts and theories regarding the formation of cluster-united enterprises, analyzing scientific concepts and theories regarding the formation of cluster-united enterprises, it was highlighted that within the limits of these theories, the concept of a cluster is complemented by such characteristics as systems of generation and dissemination of innovative ideas and experience, which in turn generally affects the modernization of the national economy. The article substantiates that cluster forms of organization of research subjects and organization of production make it possible to facilitate the commercialization of innovations and make it possible to create favorable conditions for the development of new highly specialized innovative and active areas of activity.

Conclusions from the conducted research. The article outlines that modern science still lacks a generally accepted understanding of when the first clusters appeared. The evolutionary study of the development of cluster formations and their global connections indisputably points to the growing relationship of cluster-united enterprises, where resources and competences are combined, access to target markets and know-how becomes open, information and experience are exchanged between clusters.

Keywords: cluster theory; cluster; cluster formations; clusterization.