bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular investigation of evaporation of biodroplets containing single-strand DNA on graphene surface
Authors: Akbari Fahimeh , Foroutan Masumeh
Published: January 2018

In this study, the water droplet behaviour of four different types of single-strand DNA with homogeneous base sequence on a graphene substrate during evaporation of the droplet was investigated using molecular dynamics (MD) simulation.
Rise of A-site columnar-ordered A2A′A′′B4O12 quadruple perovskites with intrinsic triple order
Authors: Belik Alexei A.
Published: January 2018

Recent progress in research on A2A′A′′B4O12 quadruple perovskites is reviewed to attract attention of the perovskite and high-pressure communities.
Hyper-cross-linked polymer supported rhodium: an effective catalyst for hydrogen evolution from ammonia borane
Authors: Xu Caili , Hu Min , Wang Qi , Fan Guangyin , Wang Yi , Zhang Yun , Gao Daojiang , Bi Jian
Published: January 2018

In situ formation of HCP-PPh3-Rh and concomitant catalytic AB hydrolysis was performed for efficient hydrogen generation from AB hydrolysis.
Earth abundant perovskite oxides for low temperature CO2conversion
Authors: Maiti Debtanu , Hare Bryan J. , Daza Yolanda A. , Ramos Adela E. , Kuhn John N. , Bhethanabotla Venkat R.
Published: January 2018

Earth abundant perovskite oxides exhibiting the highest CO2conversion rates by the RWGS-CL process at the low temperature of 500 °C.
Chondrocyte burst promotes space for mineral expansion
Authors: Hara Emilio Satoshi , Okada Masahiro , Nagaoka Noriyuki , Hattori Takako , Iida Letycia Mary , Kuboki Takuo , Nakano Takayoshi , Matsumoto Takuya
Published: January 2018

Chondrocyte burst was associated with mineralization. Manipulation of chondrocyte burst could be additional approach for cartilage and bone tissue engineering.
Design, synthesis and evaluation of (R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor
Authors: Chough Chieyeon , Lee Sunmin , Joung Misuk , Lee Jaemin , Kim Jong Hoon , Kim B. Moon
Published: January 2018

We discovered a new JAK1-selective inhibitor with a selectivity index of 48 and identified its efficacy in CIA and AIA models.
Growth of high-quality covalent organic framework nanosheets at the interface of two miscible organic solvents
Authors: Li Yang , Zhang Meicheng , Guo Xinghua , Wen Rui , Li Xing , Li Xiaofeng , Li Shoujian , Ma Lijian
Published: January 2018

A facile approach for growth of COF nanosheets at the interface of two miscible organic solvents is designed and employed.
ZnO nanodisks decorated with Au nanorods for enhanced photocurrent generation and photocatalytic activity
Authors: She Ping , Xu Kongliang , Shang Yinxing , He Qinrong , Zeng Shan , Yin Shengyan , Lu Guolong , Liang Song , Sun Hang , Liu Zhenning
Published: January 2018

AuNR-/ZnONDKs with AuNRs decorated on the surfaces of round ZnO disks demonstrate superior photocurrent generation properties and photodegradation efficiency.
Fabrication of ultralong ceria nanobelts via a coordination polymer precursor method
Authors: Li Yuan , Zou Honghong , Qiao Zhiwei , Liao Yuanyuan , Wang Lei , Zhong Shengliang
Published: January 2018

Ultralong cerium-based coordination polymer (CP) nanobelts have been successfully synthesized through a facile solvothemal approach. After calcination in air and being loaded 1 wt% Pt, the catalyst showed satisfactory activity of catalytic reduction of p-nitrophenol.
Light–matter interaction in the strong coupling regime: configurations, conditions, and applications
Authors: Dovzhenko D. S. , Ryabchuk S. V. , Rakovich Yu. P. , Nabiev I. R.
Published: January 2018

Resonance interaction between a molecular transition and a confined electromagnetic field can reach the coupling regime where coherent exchange of energy between light and matter becomes reversible.
Probing the geometry of copper and silver adatoms on magnetite: quantitative experiment versus theory
Authors: Meier Matthias , Jakub Zdeněk , Balajka Jan , Hulva Jan , Bliem Roland , Thakur Pardeep K. , Lee Tien-Lin , Franchini Cesare , Schmid Michael , Diebold Ulrike , Allegretti Francesco , Duncan David A. , Parkinson Gareth S.
Published: January 2018

Benchmarking DFT calculations against precise normal incidence X-ray standing wave measurements.
Recent advances in spectroelectrochemistry
Authors: Zhai Yanling , Zhu Zhijun , Zhou Susan , Zhu Chengzhou , Dong Shaojun
Published: January 2018

The typical structures, types, principle, application, and prospects of different kinds of spectroelectrochemistry.
Intercalation of nanostructured CeO2in MgAl2O4spinel illustrates the critical interaction between metal oxides and oxides
Authors: Duan Xinping , Wen Zhaojun , Zhao Yuxin , Zhou Junfu , Fang Huihuang , Cao Yanning , Jiang Lilong , Ye Linmin , Yuan Youzhu
Published: January 2018

Critical interaction of metal oxide-oxides:Intercalation of nanosized CeO2in MgAl spinel helps develop and maximize reactive oxygen storage/release capabilities.
Efficient perovskite/organic integrated solar cells with extended photoresponse to 930 nm and enhanced near-infrared external quantum efficiency of over 50%
Authors: Guo Qiang , Liu Hao , Shi Zhenzhen , Wang Fuzhi , Zhou Erjun , Bian Xingming , Zhang Bing , Alsaedi Ahmed , Hayat Tasawar , Tan Zhan'ao
Published: January 2018

Efficient perovskite/organic integrated solar cells with enhanced near-infrared light utilization were demonstrated.
Floating-gate controlled programmable non-volatile black phosphorus PNP junction memory
Authors: Zhang Pengfei , Li Dong , Chen Mingyuan , Zong Qijun , Shen Jun , Wan Dongyun , Zhu Jingtao , Zhang Zengxing
Published: January 2018

By designing and tailoring the structure of the floating gate, a special floating-gate field-effect transistor configuration has been proposed for the design of programmable non-volatile black phosphorus PNP junction memory.
Control of the microstructure and surface chemistry of graphene aerogels via pH and time manipulation by a hydrothermal method
Authors: García-Bordejé E. , Víctor-Román S. , Sanahuja-Parejo O. , Benito A. M. , Maser W. K.
Published: January 2018

Three-dimensional graphene aerogels of controlled pore size and reduction degree as important platform for several applications such as energy storage or oil–water separation.
Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers
Authors: Dolanský Jiří , Henke Petr , Malá Zuzana , Žárská Ludmila , Kubát Pavel , Mosinger Jiří
Published: January 2018

Polystyrene nanoparticles release nitric oxide and singlet oxygen under light and temperature control, and exhibit strong antibacterial activity.
Development of hydrolysed protein-based plywood adhesive from slaughterhouse waste: effect of chemical modification of hydrolysed protein on moisture resistance of formulated adhesives
Authors: Adhikari Birendra B. , Kislitsin Vadim , Appadu Pooran , Chae Michael , Choi Phillip , Bressler David C.
Published: January 2018

Chemical modification of hydrolysed SRM peptides by esterification reaction significantly improved the water resistance property of peptides-PAE resin-based plywood adhesive.
Highly sensitive p-type 4H-SiC van der Pauw sensor
Authors: Nguyen Tuan-Khoa , Phan Hoang-Phuong , Han Jisheng , Dinh Toan , Md Foisal Abu Riduan , Dimitrijev Sima , Zhu Yong , Nguyen Nam-Trung , Dao Dzung Viet
Published: January 2018

This paper presents for the first time a p-type 4H silicon carbide (4H-SiC) van der Pauw strain sensor by utilizing the strain induced effect in four-terminal devices.
Role of a “surface wettability switch” in inter-fiber bonding properties
Authors: Xie Jinglei , Zhang Hongjie , An Shuai , Qian Xuejun , Cheng Hongshun , Zhang Fengshan , Li Xiaoliang
Published: January 2018

The fiber surface wettability is one of the most important lignocellulosic fiber characteristics affecting the inter-fiber bonding properties of final bio-products.
Composition and role of the attached and planktonic microbial communities in mesophilic and thermophilic xylose-fed microbial fuel cells
Authors: Dessì Paolo , Porca Estefania , Haavisto Johanna , Lakaniemi Aino-Maija , Collins Gavin , Lens Piet N. L.
Published: January 2018

A mesophilic (37 °C) and a thermophilic (55 °C) two-chamber microbial fuel cell (MFC) were studied and compared for their power production from xylose and the anode-attached, membrane-attached and planktonic microbial communities involved.
Preparation of reduced graphene oxide coated flaky carbonyl iron composites and their excellent microwave absorption properties
Authors: He Lihua , Zhao Yan , Xing Liying , Liu Pinggui , Wang Zhiyong , Zhang Youwei , Wang Ying , Du Yunchen
Published: January 2018

A absorber with frequency dispersion behavior was prepared by complete surface coating of reduced graphene oxide on flaky carbonyl iron.
Fabrication of microstructured binary polymer brush “corrals” with integral pH sensing for studies of proton transport in model membrane systems
Authors: Madsen J. , Ducker R. E. , Al Jaf O. , Cartron M. L. , Alswieleh A. M. , Smith C. H. , Hunter C. N. , Armes S. P. , Leggett G. J.
Published: January 2018

Binary polymer brush microstructures incorporating ratiometric fluorescent pH indicators enablein situstudies of light-activated transmembrane proton transport by proteorhodopsin.
A water-soluble supramolecular complex that mimics the heme/copper hetero-binuclear site of cytochromecoxidase
Authors: Kitagishi Hiroaki , Shimoji Daiki , Ohta Takehiro , Kamiya Ryo , Kudo Yasuhiro , Onoda Akira , Hayashi Takashi , Weiss Jean , Wytko Jennifer A. , Kano Koji
Published: January 2018

The O2adduct of an aqueous synthetic heme/copper model system built on a porphyrin/cyclodextrin supramolecular complex has been characterized.
Efficient ammonia synthesis over a Ru/La0.5Ce0.5O1.75catalyst pre-reduced at high temperature
Authors: Ogura Yuta , Sato Katsutoshi , Miyahara Shin-ichiro , Kawano Yukiko , Toriyama Takaaki , Yamamoto Tomokazu , Matsumura Syo , Hosokawa Saburo , Nagaoka Katsutoshi
Published: January 2018

A Ru/La0.5Ce0.5O1.75catalyst pre-reduced at an unusually high temperature (650 °C) catalyses ammonia synthesis at a high rate under mild conditions.
Identification of cathode stability in Li–CO2batteries with Cu nanoparticles highly dispersed on N-doped graphene
Authors: Zhang Zhang , Zhang Zongwen , Liu Peifang , Xie Yanping , Cao Kangzhe , Zhou Zhen
Published: January 2018

Cu nanoparticles highly dispersed onto N-doped graphene may provide new strategies for designing highly efficient cathodes for Li–CO2batteries.
Surfactant-free atomically ultrathin rhodium nanosheet nanoassemblies for efficient nitrogen electroreduction
Authors: Liu Hui-Min , Han Shu-He , Zhao Yue , Zhu Ying-Ying , Tian Xin-Long , Zeng Jing-Hui , Jiang Jia-Xing , Xia Bao Yu , Chen Yu
Published: January 2018

Atomically ultrathin rhodium nanosheets obtained by the cyanogel reduction method demonstrate an excellent electrocatalytic activity for the nitrogen reduction reaction.
Enhancing the photosensitivity of C60 nanorod visible photodetectors by coupling with Cu2O nanocubes
Authors: Cai Baofang , Su Yanjie , Hu Jing , Zou Cheng , Zhang Yafei
Published: January 2018

The photosensitivity of C60 nanorod visible photodetectors has been enhanced significantly by coupling with Cu2O nanocubes due to the increasing separation efficiency of photo-induced electrons/holes at the interface.
Oxidation of rubrene, and implications for device stability
Authors: Ly Jack T. , Lopez Steven A. , Lin Janice B. , Kim Jae Joon , Lee Hyunbok , Burnett Edmund K. , Zhang Lei , Aspuru-Guzik Alán , Houk K. N. , Briseno Alejandro L.
Published: January 2018

In studying the formation and thermally activated cycloreversion of oxidized rubrene to pristine rubrene, we observed an irreversible, second stage oxidized product. Understanding the formation of the irreversible adduct will help one design more chemically robust rubrene derivatives.
Optofluidic gutter oil discrimination based on a hybrid-waveguide coupler in fibre
Authors: Lin Chupao , Liao Changrui , Zhang Yunfang , Xu Lei , Wang Ying , Fu Cailing , Yang Kaiming , Wang Jia , He Jun , Wang Yiping
Published: January 2018

We propose an ultrasensitive optofluidic detection method based on a hybrid-waveguide coupler for the discrimination of edible oils from gutter oils.
Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study
Authors: Alagia Adele , Jorge Andreia F. , Aviñó Anna , Cova Tânia F. G. G. , Crehuet Ramon , Grijalvo Santiago , Pais Alberto A. C. C. , Eritja Ramon
Published: January 2018

A direct connection between the PAZ/3′-overhang binding affinity and the siRNA potency and specificity is defined through complementary experimental and computational results.
Open‐loop per‐pin skew compensation with lock fault detector for parallel NAND flash memory interface
Authors: Kang K.‐T. , Kim S.‐Y. , Lee K.‐Y.
Published: January 2018

An open‐loop per‐pin skew compensation with lock fault detection is presented. The proposed circuit employs an open‐loop reference selector, a two‐stage open‐loop delay lock method which is separated by a coarse and fine lock for fast lock‐in time, and a fault lock detecting scheme to prevent lock fault by dead zone of samplers. A unidirectional scan method ahead the fine lock stage to minimise pin‐to‐pin skew errors after calibration is also applied. The circuit was fabricated with 55 nm CMOS technology with a 1 V supply voltage and an area of 0.0036 mm2 for one de‐skewing module. The measured result shows that the skew error at 1 GHz operation was reduced to <6 ps after skew calibration when the skew between input/output (IO) pins was 230 ps, and the lock‐in time was 11 clock cycles.
Optimal allocation of BESS and MT in a microgrid
Authors: Qiu Jing , Zhao Junhua , Zheng Yu , Dong Zhaohui , Dong Zhao Yang
Published: January 2018

This study presents a two‐stage planning framework of the battery energy storage system (BESS) and micro‐turbine (MT) in a microgrid. In the first stage, the optimal allocation decisions are made before the actual realisation of the operational uncertainties. In the second stage, the optimal operation strategies are made for the microgrid by minimising the costs paid to the main grid, fuel cells, MTs, BESSs and controllable loads (CLs). The hot water system and interruptible load are considered as CLs. Their mathematical models are built to investigate their roles in smoothing renewable energy. In addition, efforts are made to keep the linearity of the formulated optimisation problem, and the backward scenario reduction method is adopted to further enhance the computational efficiency. The modified IEEE 33‐bus radial system is used as a microgrid to verify the effectiveness of the proposed approach for both islanded and grid‐connected microgrids. Sensitivity analysis has been conducted to compare the economics and robustness of the identified solutions.
Imprints of the large-scale structure on AGN formation and evolution
Authors: Porqueres Natàlia , Jasche Jens , Enßlin Torsten A. , Lavaux Guilhem
Published: January 2018

Black hole masses are found to correlate with several global properties of their host galaxies, suggesting that black holes and galaxies have an intertwined evolution and that active galactic nuclei (AGN) have a significant impact on galaxy evolution. Since the large-scale environment can also affect AGN, this work studies how their formation and properties depend on the environment. We have used a reconstructed three-dimensional high-resolution density field obtained from a Bayesian large-scale structure reconstruction method applied to the 2M++ galaxy sample. A web-type classification relying on the shear tensor is used to identify different structures on the cosmic web, defining voids, sheets, filaments, and clusters. We confirm that the environmental density affects the AGN formation and their properties. We found that the AGN abundance is equivalent to the galaxy abundance, indicating that active and inactive galaxies reside in similar dark matter halos. However, occurrence rates are different for each spectral type and accretion rate. These differences are consistent with the AGN evolutionary sequence suggested by previous authors, Seyferts and Transition objects transforming into low-ionization nuclear emission line regions (LINERs), the weaker counterpart of Seyferts. We conclude that AGN properties depend on the environmental density more than on the web-type. More powerful starbursts and younger stellar populations are found in high densities, where interactions and mergers are more likely. AGN hosts show smaller masses in clusters for Seyferts and Transition objects, which might be due to gas stripping. In voids, the AGN population is dominated by the most massive galaxy hosts.
Polarized point sources in the LOFAR Two-meter Sky Survey: A preliminary catalog
Authors: Van Eck C. L. , Haverkorn M. , Alves M. I. R. , Beck R. , Best P. , Carretti E. , Chyży K. T. , Farnes J. S. , Ferrière K. , Hardcastle M. J. , Heald G. , Horellou C. , Iacobelli M. , Jelić V. , Mulcahy D. D. , O’Sullivan S. P. , Polderman I. M. , Reich W. , Riseley C. J. , Röttgering H. , Schnitzeler D. H. F. M. , Shimwell T. W. , Vacca V. , Vink J. , White G. J.
Published: January 2018

The polarization properties of radio sources at very low frequencies (<200 MHz) have not been widely measured, but the new generation of low-frequency radio telescopes, including the Low Frequency Array (LOFAR: a Square Kilometre Array Low pathfinder), now gives us the opportunity to investigate these properties. In this paper, we report on the preliminary development of a data reduction pipeline to carry out polarization processing and Faraday tomography for data from the LOFAR Two-meter Sky Survey (LOTSS) and present the results of this pipeline from the LOTSS preliminary data release region (10h45m–15h30m right ascension, 45°–57° declination, 570 square degrees). We have produced a catalog of 92 polarized radio sources at 150 MHz at 4.′3 resolution and 1 mJy rms sensitivity, which is the largest catalog of polarized sources at such low frequencies. We estimate a lower limit to the polarized source surface density at 150 MHz, with our resolution and sensitivity, of 1 source per 6.2 square degrees. We find that our Faraday depth measurements are in agreement with previous measurements and have significantly smaller errors. Most of our sources show significant depolarization compared to 1.4 GHz, but there is a small population of sources with low depolarization indicating that their polarized emission is highly localized in Faraday depth. We predict that an extension of this work to the full LOTSS data would detect at least 3400 polarized sources using the same methods, and probably considerably more with improved data processing.
Radio outburst from a massive (proto)star
Authors: Cesaroni R. , Moscadelli L. , Neri R. , Sanna A. , Caratti o Garatti A. , Eislöffel J. , Stecklum B. , Ray T. , Walmsley C. M.
Published: January 2018

Context. Recent observations of the massive young stellar object S255 NIRS 3 have revealed a large increase in both methanol maser flux density and IR emission, which have been interpreted as the result of an accretion outburst, possibly due to instabilities in a circumstellar disk. This indicates that this type of accretion event could be common in young/forming early-type stars and in their lower mass siblings, and supports the idea that accretion onto the star may occur in a non-continuous way.

Aims. As accretion and ejection are believed to be tightly associated phenomena, we wanted to confirm the accretion interpretation of the outburst in S255 NIRS 3 by detecting the corresponding burst of the associated thermal jet.

Methods. We monitored the radio continuum emission from S255 NIRS 3 at four bands using the Karl G. Jansky Very Large Array. The millimetre continuum emission was also observed with both the Northern Extended Millimeter Array of IRAM and the Atacama Large Millimeter/Submillimeter Array.

Results. We have detected an exponential increase in the radio flux density from 6 to 45 GHz starting right after July 10, 2016, namely ~13 months after the estimated onset of the IR outburst. This is the first ever detection of a radio burst associated with an IR accretion outburst from a young stellar object. The flux density at all observed centimetre bands can be reproduced with a simple expanding jet model. At millimetre wavelengths we infer a marginal flux increase with respect to the literature values and we show this is due to free–free emission from the radio jet.

Conclusions. Our model fits indicate a significant increase in the jet opening angle and ionized mass loss rate with time. For the first time, we can estimate the ionization fraction in the jet and conclude that this must be low (<14%), lending strong support to the idea that the neutral component is dominant in thermal jets. Our findings strongly suggest that recurrent accretion + ejection episodes may be the main route to the formation of massive stars.
Scalable Synthesis of Amaryllidaceae Isocarbostyril Alkaloids from Enantiomerically Pure 7-Azabicyclo[2.2.1]heptanone Scaffold: Total Synthesis of (+)-7-Deoxypancratistatin
Authors: Pandey Ganesh , Fernandes Rushil , Dey Debasis
Published: January 2018

A conceptually new and scalable strategy (ten linear steps, 13.9% overall yield) has been developed to synthesize (+)-7-deoxy­pancratistatin from optically pure 7-azabicyclo[2.2.1]heptanone scaffold. The crucial trans-B–C ring junction was fixed at an early stage of the synthesis by exploiting the rigid bicyclic structural framework of the starting precursor. Stereoselective installation of hydroxyl groups around the perimeter of the cyclohexenyl C-ring involved sequential epoxidation–phenylselenylation–oxydeselenylation sequence followed by dihydroxylation. The most attractive feature of this synthesis is the use of a protection–deprotection step only at the penultimate step making the protocol very efficient and atom economical.
NHPI- and TBAI-Co-Catalyzed Synthesis of Allylic Esters from Toluene Derivatives and Alkenes
Authors: Deng Hongmei , Jia Xueshun , Li Jian , Li Chengliang , Jin Tao , Li Chunju
Published: January 2018

An N-hydroxyphthalimide (NHPI) and tetrabutylammonium iodide (TBAI) co-catalyzed oxidative coupling reaction of toluene derivatives and alkenes has been disclosed. This method can serve as a new strategy to access allylic ester using toluene derivatives as oxyacylating reagent. This metal-free protocol also features the readily available starting materials, broad substrate scope, and mild reaction conditions.
Treatment of Central Nervous System Tuberculosis
Authors: Ahmed Amina
Published: January 2018

Central nervous system tuberculosis (CNS-TB) manifests as tuberculous meningitis, intracranial tuberculoma, or spinal tuberculous arachnoiditis. Children are disproportionately affected, with high rates of mortality and morbidity reported even in the era of treatment. Most guidelines for the treatment of drug-susceptible CNS-TB recommend 9 to 12 months of a standard regimen of isoniazid, rifampin, pyrazinamide, and ethambutol, with the adjunctive use of corticosteroids early in therapy. Recent trials have demonstrated improved outcomes with intensified regimens using nonstandard regimens or higher dosages of standard drugs. Accumulating evidence also supports shorter duration of treatment. Further investigation is warranted to identify the optimal regimen and duration of treatment for CNS-TB. Complications such as hydrocephalus may be managed medically or surgically. Although outcomes have improved with effective chemotherapy and immunomodulation of disease, prompt diagnosis and treatment in the early stages of disease remain paramount to improve prognosis.
Endoscope-Assisted Microsurgical Removal of an Optic Foramen Meningioma through a Frontolateral Minicraniotomy
Authors: Kurucz Peter , Opitz Holger , Buchfelder Michael , Ganslandt Oliver
Published: January 2018

A 72-year-old male patient with visual disturbance of the right eye was diagnosed with a small meningioma of the right optic foramen extending to the carotid cistern. The operation was performed through an individually tailored frontolateral minicraniotomy via a curvilinear skin incision behind the hairline. Endoscope-assisted microsurgical technique was used to resect the lesion. The roof of the optic canal was partly removed to get access to the intraforaminal tumor parts. The lesion could be completely removed and the patient showed a satisfactory visual recovery in the follow-up examinations.

The link to the video can be found at: https://youtu.be/p8EZx7aryeQ.
Fat Mass and Obesity-Related Gene Variants rs9939609 and rs7185735 are Associated with Second-Generation Antipsychotic-Induced Weight Gain
Authors: Schröder Charlotte , Czerwensky Fabian , Leucht Stefan , Steimer Werner
Published: January 2018

Introduction Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy.

Methods We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were included in a naturalistic study.

Results After 4 weeks of treatment, we did not observe any significant association of polymorphisms with weight change in the whole study population (p>0.05). In a subpopulation without additional weight-inducing comedication (n=178), G-allele carriers of rs7185735 gained 3.4 times more weight (1.69 kg±3.1 kg, p=0.019) than AA genotypes (0.49 kg±3.1 kg). A-allele carriers of rs9939609 gained 3.1 times more weight (1.65 kg±3.1 kg, p=0.029) than TT genotypes (0.54 kg±3.2 kg).

Discussion Our findings confirm the role of the FTO gene as a high-potential risk factor for obesity and indicate a value for predicting a weight gain induced by second-generation antipsychotics. Further, we detected an additive effect of FTO rs7185735 and MC4R rs17782313.
Correlates of Mental Health Diversion Completion in a Canadian Consortium
Authors: Seto Michael C. , Basarke Sonya , Healey Lindsay V. , Sirotich Frank
Published: January 2018

Mental health diversion is an important option for offenders with mental illness who do not pose a serious risk to public safety and who would otherwise be better served outside the criminal justice system. Predictors of complete vs. incomplete diversion were examined in a sample of 708 defendants seen in Toronto's mental health diversion programs. Univariate analyses revealed that unsuccessfully diverted defendants were significantly more likely to be younger, homeless, and have more clinical and legal needs compared to those who were successfully diverted. In multivariate analyses, criminological factors (e.g., criminal history) had the strongest association with diversion completion, compared to clinical (e.g., primary diagnosis) and psychosocial (e.g., employment status) factors outside of marital status, which was strongly associated with completion. The results from this research add to previous research on mental health courts and diversion by giving guidance on how to select and prepare diversion candidates. These findings suggest that diversion programs may benefit from adaptations in order to better suit high need clients.
Miranda Misconceptions of Criminal Detainees: Differences Based on Age Groups and Prior Arrests
Authors: Winningham Darby B. , Rogers Richard , Drogin Eric Y.
Published: January 2018

Knowing and intelligent Miranda waivers remain the cornerstone of our 5th Amendment right against self-incrimination in the United States. Until recently, however, Miranda-related research and practice have focused almost entirely on comprehension of proffered warnings and waivers as opposed to identifying ingrained misconceptions that affect how detainees process this input. The current archival investigation brings together data on Miranda misconceptions for more than 799 detainees in the United States, ranging from 11–67 years of age. Miranda misconceptions were systematically examined on the Miranda Quiz (MQ) and parallel items of the Juvenile Miranda Quiz (JMQ) across four age groups (i.e., younger juveniles, older juveniles, emerging adults, and adults) with varying histories of prior arrests. As expected, the two adult groups had fewer Miranda misconceptions than the two juvenile groups. Contrary to widespread assumptions, serious Miranda misconceptions commonly occur, even among detainees with intact verbal abilities and those with extensive arrest histories.
Density-Dependent Conformable Space-time Fractional Diffusion-Reaction Equation and Its Exact Solutions
Authors: Hosseini Kamyar , Mayeli Peyman , Bekir Ahmet , Guner Ozkan
Published: January 2018

In this article, a special type of fractional differential equations (FDEs) named the density-dependent conformable fractional diffusion-reaction (DDCFDR) equation is studied. Aforementioned equation has a significant role in the modelling of some phenomena arising in the applied science. The well-organized methods, including the

exp
(
−
ϕ
(
ε
)
)

-expansion and modified Kudryashov methods are exerted to generate the exact solutions of this equation such that some of the solutions are new and have been reported for the first time. Results illustrate that both methods have a great performance in handling the DDCFDR equation.
The Vienna consensus: report of an expert meeting on the development of art laboratory performance indicators†‡
Authors:   ESHRE Special Interest Group of Embryology,   Alpha Scientists in Reproductive Medicine
Published: January 2018

STUDY QUESTION

What are appropriate performance indicators (PIs) for ART laboratories for use in monitoring ‘fresh’ IVF and ICSI cycles?

SUMMARY ANSWER

Minimum performance (competence) levels and aspirational (benchmark) values were recommended for a total of 19 indicators, including 12 key PIs (KPIs), five PIs and two reference indicators (RIs).

WHAT IS ALREADY KNOWN

PIs are necessary for systematic monitoring of the laboratory and an important element within the Quality Management System. However, there are no established PIs for ART laboratories and there is very little evidence on the topic.

STUDY DESIGN, SIZE, DURATION

This is the report of a 2-day consensus meeting of expert professionals. As a starting point for the discussion, two surveys were organized to collect information on indicators used in IVF laboratories. During the meeting, the results of the surveys, scientific evidence (where available), and personal clinical experience where integrated into presentations by experts on specific topics. After presentation, each proposed indicator was discussed until consensus was reached within the panel.

PARTICIPANTS/MATERIALS, SETTING, METHODS

Expert professionals representing different countries and settings convened in the consensus meeting.

MAIN RESULTS AND THE ROLE OF CHANCE

The paper is divided in two parts: the workshop report and the recommendations of the expert panel. The second part reflects the discussion on each of the indicators, with the agreed definition, competence level and benchmark value for each of the 19 indicators, including 12 KPIs, 5 PIs and 2 RIs.

LIMITATIONS, REASONS FOR CAUTION

The KPIs are mainly based on expert opinion. Future research may warrant an update of the recommended KPIs, their definition and the competence level and benchmark values.

WIDER IMPLICATIONS OF THE FINDINGS

Based on the information presented, each ART laboratory should select its own set of KPIs founded on laboratory organization, and processes.

STUDY FUNDING/COMPETING INTEREST(S)

The consensus meeting and writing of the paper was supported by funds from ESHRE and Alpha. Alpha gratefully acknowledges the following organizations for their financial support, through the provision of unrestricted educational grants: Global Fertility Alliance, Merck, Origio and Vitrolife. There are no conflicts of interest to disclose,
The dipole anisotropy of WISE × SuperCOSMOS number counts
Authors: Bengaly C A P , Novaes C P , Xavier H S , Bilicki M , Bernui A , Alcaniz J S
Published: January 2018

We probe the isotropy of the Universe with the largest all-sky photometric redshift data set currently available, namely WISE × SuperCOSMOS. We search for dipole anisotropy of galaxy number counts in multiple redshift shells within the 0.10 < z < 0.35 range, for two subsamples drawn from the same parent catalogue. Our results show that the dipole directions are in good agreement with most of the previous analyses in the literature, and in most redshift bins the dipole amplitudes are well consistent with Lambda cold dark matter-based mocks in the cleanest sample of this catalogue. In the z < 0.15 range, however, we obtain a persistently large anisotropy in both subsamples of our data set. Overall, we report no significant evidence against the isotropy assumption in this catalogue except for the lowest redshift ranges. The origin of the latter discrepancy is unclear, and improved data may be needed to explain it.
Intracranial Dural Arteriovenous Fistulas with Pial Arterial Supply
Authors: Osada Takahiro , Krings Timo
Published: January 2018

BACKGROUND

Pial arterial supplies are sometimes found in patients with dural arteriovenous fistulas (DAVFs), though their characteristics have rarely been clarified.

OBJECTIVE

To investigate the characteristics of pial arterial supplies in DAVFs and to discuss their pathophysiology and treatment.

METHODS

Two hundred four consecutive patients with intracranial DAVFs over 11 yr were retrospectively reviewed. Clinical factors and radiological findings, including the presence of pial arterial supplies, were evaluated. Supply from a pial artery was classified into 2 categories: dilated pre-existing dural branches of pial arteries, and a “pure” pial supply.

RESULTS

Twenty-three of 204 patients (11.3%) showed an additional pial arterial supply. Multivariate analysis identified 3 independent predictors of a pial arterial supply: younger age (P < .0005), DAVF within the tentorium (P = .0162), and presence of venous dilatation (P = .0001). A dilated pre-existing dural branch of a pial artery was identified in 17 patients, while 8 had a pure pial supply. Of these 23 patients, 17 underwent interventional therapy. No postoperative intracranial hemorrhage or infarction occurred in patients with pial arterial supplies.

CONCLUSION

An additional pial supply is not uncommon in DAVFs and may be explained by a rich physiological pial arterial supply to the dura mater from the posterior circulation, while potential angiogenesis due to venous hypertension remains speculative. Prior to interventional treatment for DAVFs, recognition of a pial arterial supply to the DAVF might influence the treatment strategy and could help avoid inadvertent retrograde embolization of brain supplying vessels through the pial network.
Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial
Authors: Giordano Frank A , Brehmer Stefanie , Mürle Bettina , Welzel Grit , Sperk Elena , Keller Anke , Abo-Madyan Yasser , Scherzinger Elisabeth , Clausen Sven , Schneider Frank , Herskind Carsten , Glas Martin , Seiz-Rosenhagen Marcel , Groden Christoph , Hänggi Daniel , Schmiedek Peter , Emami Bahman , Souhami Luis , Petrecca Kevin , Wenz Frederik
Published: January 2018

BACKGROUND

The median time to recurrence of glioblastoma (GB) following multimodal treatment is ∼7 mo. Nearly all cancers recur locally, suggesting that augmenting local treatments may improve outcomes.

OBJECTIVE

To investigate whether intraoperative radiotherapy (IORT) to the resection cavity is safe and effective.

METHODS

INTRAGO was a phase I/II trial to evaluate the safety and tolerability of IORT with 20 to 40 Gy of low-energy photons in addition to standard radiochemotherapy (ClinicalTrials.gov ID, NCT02685605). The primary endpoint was safety as per occurrence of dose-limiting toxicities. Secondary endpoints were progression-free survival (PFS) and overall survival (OS). We also performed an exploratory analysis of the local PFS (L-PFS), defined as recurrence within 1 cm of the treated margin.

RESULTS

Fifteen patients were treated at 3 dose levels. Of these, 13 underwent incomplete resection, 6 had unresected satellites, and 3 did not receive per-protocol treatment (PPT). The MGMT promoter was unmethylated in 10 patients. The median follow-up was 13.8 mo. The majority of grade 3 to 5 adverse events were deemed unrelated to IORT. Five cases of radionecrosis were observed, 2 were classified as grade 3 events. Other grade 3 events judged related to radiotherapy (external-beam radiotherapy and/or IORT) were wound dehiscence (n = 1), CSF leakage (n = 1), cyst formation (n = 1). No IORT-related deaths occurred. The median PFS was 11.2 mo (95% confidence interval [CI]: 5.4-17.0) for all patients and 11.3 mo (95% CI: 10.9-11.6) for those receiving PPT. The median L-PFS was 14.3 mo (95% CI: 8.4-20.2) for all patients and 17.8 mo (95% CI: 9.7-25.9) for those receiving PPT. The median OS was 16.2 mo (95% CI: 11.1-21.4) for all patients and 17.8 mo (95% CI: 13.9-21.7) for those receiving PPT.

CONCLUSION

These data suggest that IORT is associated with manageable toxicity. Considering the limitations of a 15-patient phase I/II trial, further studies aimed at assessing an outcome benefit are warranted.
The Pedicled LICAP Flap Combined with a Free Abdominal Flap In Autologous Breast Reconstructions
Authors: Sjøberg Thomas , de Weerd Louis
Published: January 2018

Background:

Previous surgery or slim body configuration can limit the size of the available abdominal flap in autologous breast reconstruction. However, redundant skin and subcutaneous tissue lateral to the mastectomy site can be utilized as the pedicled lateral intercostal artery perforator (LICAP) flap. This study evaluates the combination of a free abdominal flap and a pedicled LICAP flap to achieve increased breast size and improved cosmetic outcome.

Methods:

Patients undergoing secondary autologous breast reconstruction were included in a prospective study. The combination with a LICAP flap was used for women with insufficient abdominal flap tissue in relation to the desired breast size. The authors also assessed their modification of the original lateral thoracodorsal flap design to improve the aesthetic outcome.

Results:

In 109 patients, 121 free abdominal flaps were performed. The combination with a pedicled LICAP flap was used in 82 free abdominal flap reconstructions (68%). The LICAP flap provided additional volume and resulted in better projection and ptosis of the neo-mamma. The overall complication rate for the LICAP flaps was 26 %; all minor complications. Despite combining flaps, the majority of patients needed additional surgery to improve breast symmetry. Breast reduction of the native breast was the most common symmetrizing procedure.

Conclusion:

In selected patients with insufficient abdominal flap tissue, a combination of a free abdominal flap and a pedicled LICAP flap is a valuable option to increase breast size and cosmetic outcome. Additional symmetrizing surgery might still be necessary.
Earfold Implantable Clip System for Correction of Prominent Ears: Analysis of Safety in 403 Patients
Authors: Kang Norbert V. , Sojitra Nilesh , Glumicic Sinisa , Vlok Jacobus A. , O’Toole Greg , Hannan S. Alam , Sabbagh Walid
Published: January 2018

Background:

The Earfold system, a new treatment for the correction of prominent ears, consists of 3 components: the Earfold implant, the Earfold introducer, and the Prefold positioner.

Methods:

This is an interim report based on an ongoing analysis of safety in a series of patients treated for prominent ears with the Earfold implant between February 2013 and September 2014. Safety was assessed based on adverse event reports and the need for implant revision; follow-up is ongoing.

Results:

Seven surgeons used 1,200 Earfold implants to treat 403 patients (ages, 7–70 years; 63% male); the time since the initial implant procedure now ranges from 30 to 48 months. To date, 145 patients (36%) have returned for a follow-up visit (mean, 7.7 months [range, 1–34 months]). Adverse events requiring intervention have affected 39 of 403 (9.7%) patients; these include implant revisions (n = 17 [4.2%], most often due to implant visibility), skin erosion over the implant (n = 15 [3.7%]), and infection (n = 7 [1.7%]). Bleeding, recurrence of prominence, hematoma, deformity, or adverse scarring did not occur.

Conclusions:

This interim analysis has shown that Earfold prominent ear correction system is associated with relatively few adverse events that require intervention; a small number of patients experienced infection, implant extrusion, or implant visibility that required revision. Most adverse events were related to either patient selection or technical errors at implantation. It is expected that with continued use of Earfold by surgeons experienced in otoplasty, the adverse event incidence will decrease.
Hinge Flap with Triangular Extension for Reconstruction of Pharyngocutaneous and Laryngocutaneous Fistulas
Authors: Azuma Ryuichi , Aoki Shimpo , Kuwabara Masahiro , Aizawa Tetsushi , Nagano Hisato , Kiyosawa Tomoharu
Published: January 2018

Hinge flaps are commonly used for closure of a pharyngocutaneous fistula (PCF) or laryngocutaneous fistula. These flaps are employed to augment the wall of the pharynx or larynx, but the junction between the reconstructed and native lumens can eventually become narrow and irregular after reconstruction with standard hinge flaps. We devised a method of adding a triangular extension to the end of either or both flaps and used it to treat 3 patients. In 1 patient who developed a PCF (4 × 10 cm) after laryngectomy followed by radiotherapy, the fistula was closed with 2 hinge flaps. One flap had a caudal triangular extension. The residual skin defect was covered by a pedicled latissimus dorsi musculocutaneous flap. Another patient who developed a PCF (2.5 × 3 cm) after laryngectomy underwent 2-stage reconstruction using a buccal mucosal graft with a triangular extension, followed by 2 hinge flaps. A patient who developed an laryngocutaneous fistula (1 × 2 cm) after radiotherapy and subsequent partial laryngectomy underwent reconstruction using 2 hinge flaps, each of which had a triangular extension. The skin defect was covered by another flap. Postoperative CT or video fluoroscopic examination of swallowing showed a smooth lumen with no strictures in all 3 patients. The triangular extension of the hinge flap supplements the pharyngeal/laryngeal wall at the junction between the reconstructed and intact regions, thus avoiding postoperative stricture. Especially with PCF reconstruction, restoration of a smooth luminal surface minimizes dysphagia.
Adverse Economic Impact Associated With Blood Culture Contamination in a Pediatric Emergency Department
Authors: Murofushi Yuka , Furuichi Munehiro , Shoji Kensuke , Kubota Mitsuru , Ishiguro Akira , Uematsu Satoko , Gai Ruoyan , Miyairi Isao
Published: January 2018

Background:

Blood culture contamination (BCC) leads to unnecessary interventions including hospitalization, antibiotic administration and additional laboratory tests. Previous studies in adults revealed that BCC was associated with unnecessary financial expenditures. However, information pertaining to the pediatric population is limited. Therefore, we investigated the details of the adverse economic impact associated with BCC in a pediatric emergency department (ED) in Japan.

Methods:

This study was a retrospective, observational study. We collected data on blood cultures performed in patients 18 years of age in a pediatric ED. Medical records of patients with positive blood cultures were reviewed, and the information regarding adverse events related to BCC was extracted. Medical costs related to BCC were estimated from the data.

Results:

In total, 13,139 sets of blood cultures were performed from April 2013 to June 2016, and 141 cases (1.1%) of BCC were identified. Among these, 106 patients (75%) experienced at least 1 adverse event associated with BCC. The total medical cost due to BCC was 4,076,713 Japanese yen. Multifaceted approaches targeting ED physicians including lectures on optimal blood collection methods and monthly feedback on BCC rates were effective in reducing the BCC rate and its related costs.

Conclusions:

Interventions associated with BCC were common and accounted for significant adverse economic impact on pediatric patients. Regular education and monitoring were effective in reducing BCC and its related costs.
A Cross-sectional Study to Compare Hepatitis B Immunity in HIV-infected and HIV-uninfected Kenyan Children After Primary Hepatitis B Immunization
Authors: Mbuthia Joseph K. , Kabera Beatrice M. , Karuga Robinson , Ivui Grace , Mainye Sheila , Chanzu Nadia Musimbi , Digolo Lina
Published: January 2018

To evaluate protective antibody levels against hepatitis B surface antigen in HIV-infected and HIV-uninfected Kenyan children, this study enrolled 531 children. In the HIV-infected group, only 18.3% had protective hepatitis B surface antigen compared with 74.4% in the HIV-uninfected group (P < 0.0001). Perhaps HIV-infected children should be immunized differently.
Seminoma Metastatic to the Orbit
Authors: Dutton Jonathan J. , Proia Alan D.
Published: January 2018

Purpose:

Seminomas are solid tumors in young men, but which rarely metastasize to the orbit. The authors review the known literature on seminoma metastatic to the orbit, and describe an additional case in a 33-year-old man.

Methods:

A literature search was performed on the MEDLINE database using keywords “seminoma,” “testicular germ-cell tumors,” “testicular cancer,” “testicular neoplasm,” “orbital metastasis,” and “germ-cell neoplasms.”

Results:

Malignant neoplasms of the testis account for only 1% of cancers in men. None-the-less, testicular germ cell seminoma is the most common solid tumor found in young men between the ages of 15 and 39. Only seven previous cases have been mentioned in the literature. The pathogenesis remains unclear although genetic, environmental, and maternal factors may play a role. The number of cases is too few to determine the best treatment options, but surgical excision and adjunctive orbital radiotherapy appear to be most appropriate.

Conclusions:

Although metastases to the orbit are rare, seminoma should be considered in the differential diagnosis of all young men with proptosis.