bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary diversity, undernutrition and associated factors among pregnant women in Gindeberet district, Oromia, Ethiopia: a cross-sectional study
Authors: Tafasa Segni Mulugeta , Darega Jiregna , Dida Nagasa , Gemechu Feyisa Dudema
Published: October 2023

Background

Appropriate levels of dietary diversity are essential for proper physiology of human being and it is crucial to consume healthy foods at every phase of life, especially during pregnancy. Inadequate dietary diversity and malnutrition are risk factors for low birth weight, intrauterine growth reduction and small for gestational age. This study was aimed to assess dietary diversity, undernutrition and associated factors among pregnant women in Gindeberet district, Oromia, Ethiopia, 2020.

Method

A community based cross-sectional study was conducted among 627 pregnant women in Gindeberet district selected by systematic random sampling from October 10/2020– November 10/2020. Data were collected through interviewer administered questionnaires. The collected data were coded and entered to Epi-info version 7.2.2.6 and analyzed by SPSS version 23. Logistic regression analysis was carried out to identify factor associated with undernutrition and dietary diversity. Level of statistical significance was declared at p-value < 0.05.

Results

overall prevalence of inadequate dietary diversity and undernutrition were 276 (44.4%) and 110 (17.7%) respectively. Pregnant women who did not receive antenatal care (AOR = 2.32, [95% CI: 1.38, 3.90]), family size ≥ 5 (AOR: 2.93; [95%CI: 1.10, 7.79]), unprotected sources of water (AOR: 4.14; [95% CI: 1.63, 10.52]) were significantly associated with undernutrition. Rural residence (AOR = 2.59, [95% CI: 1.66–4.04]), pregnant women who did not received ANC (AOR = 2.52, [95% CI: 1.58–4.03]) and nutrition information (AOR = 1.43; [95% CI: 1.10, 2.10]) were significantly associated with dietary diversity among pregnant women.

Conclusion

undernutrition and inadequate dietary diversity among pregnant women were high in study area. Source of drinking water, ANC visit and family size were significantly associated with pregnant women undernutrition. Place of residence, ANC visit and nutrition information were significantly associated with inadequate dietary diversity. Therefore, pregnant women, government, non-governmental organization and stakeholders should focus on importance of ANC visit, clean source of drinking water and adequate dietary diversity to improve nutritional status of pregnant women.
Fully automated radiosynthesis of [68Ga]Ga-FAPI-46 with cyclotron produced gallium
Authors: Rosenberg Adam J. , Cheung Yiu-Yin , Liu Fei , Sollert Carina , Peterson Todd E. , Kropski Jonathan A.
Published: October 2023

Background

Radiopharmaceuticals capable of targeting the fibroblast activation protein have become widely utilized in the research realm as well as show great promise to be commercialized; with [68Ga]Ga-FAPI-46 being one of the most widely utilized. Until now the synthesis has relied on generator-produced gallium-68. Here we present a developed method to utilize liquid-target cyclotron-produced gallium-68 to prepare [68Ga]Ga-FAPI-46.

Results

A fully-automated manufacturing process for [68Ga]Ga-FAPI-46 was developed starting with the 68Zn[p,n]68Ga cyclotron bombardment to provide [68Ga]GaCl3, automated purification of the [68Ga]GaCl3, chelation with the precursor, and final formulation/purification. The activity levels produced were sufficient for multiple clinical research doses, and the final product met all release criteria. Furthermore, the process consistently provides < 2% of Ga-66 and Ga-67 at the 4-h expiry, meeting the Ph. Eur. standards.

Conclusions

The automated radiosynthesis on the GE FASTlab 2 module purifies the cyclotron output into [68Ga]GaCl3, performs the labeling, formulates the product, and sterilizes the product while transferring to the final vial. Production of > 40 mCi (> 1480 MBq) of [68Ga]Ga-FAPI-46 in excellent radiochemical yield was achieved with all batches meeting release criteria.
Depression and health-related quality of life of patients with type 2 diabetes attending tertiary level hospitals in Dhaka, Bangladesh
Authors: Namdeo Manish K. , Verma Sarita , Das Gupta Rajat , Islam Rubana , Nazneen Shaila , Rawal Lal B.
Published: October 2023

Introduction

Type 2 diabetes mellitus (T2DM) and depression are closely linked. People with T2DM are at increased risk of developing depression and vice versa. T2DM and depression comorbid conditions adversely affect Health-Related Quality of Life (HRQOL) and management of T2DM. In this study, we assessed depression and HRQOL among patients with T2DM in Dhaka, Bangladesh.

Methods

A cross-sectional study was conducted in two tertiary-level hospitals in Dhaka, Bangladesh. Data were collected from 318 patients with T2DM. A set of standard tools, PHQ-9 (for assessing depression) and EuroQol-5D-5L (for assessing the HRQOL), were used. Statistical analyses, including Chi-square and Fisher's exact tests, Wilcoxon (Mann–Whitney), and Spearman's correlation coefficient tests, were performed using SPSS (v.20).

Results

The majority of the patients (58%) were females, with a mean age (standard deviation) of 52 ± 10 years, and 74% of patients lived in urban areas. The prevalence of depression was 62% (PHQ-9 score ≥ 5). Over three-quarters (76%) reported problems in the anxiety/ depression dimension of EQ-5D, followed by pain/discomfort (74%), mobility (40%), self-care (36%), and usual activities (33%). The depression and T2DM comorbid condition were associated with all the five dimensions of EQ-5D (χ2 statistics with df = 1 was 52.33, 51.13, 52.67, 21.61, 7.92 for mobility, self-care, usual activities, pain/discomfort, and anxiety/ depression dimensions respectively, p- < 0.01). The mean EQ-5D index (0.53 vs. 0.75) and the mean EQ-5D VAS (65 vs. 76) both showed lower values in T2DM patients with depression compared to T2DM patients without depression (Wilcoxon test, p- < 0.001).

Conclusions

We conclude that the majority of the patients with T2DM had comorbid conditions, and the HRQOL was negatively affected by comorbid depression in T2DM patients. This suggests the importance of timely screening, diagnosis, treatment, and follow-up of comorbid depression in T2DM patients to improve overall health and QOL.
Post-operative cerebrospinal fluid leak: single-continuous versus double-breasted dural repair of myelomeningocele
Authors: Daibu Usman , Koko Aliyu Muhammad , Usman Babagana
Published: October 2023

Background

Myelomeningocele is the most common neural tube defect in our environment. Initial surgical management involves untethering and water-tight dural closure. Single-continuous dural repair is more straightforward and faster than the double-breasted repair, even though the latter offers more strength to the reconstructed dura as the repair is in two layers. Preference was given to single-continuous repair even though the two techniques were not compared in terms of post-operative cerebrospinal fluid leak. The aim of this study was to compare the frequency of cerebrospinal fluid (CSF) leak following single-continuous versus double-breasted dural repair of myelomeningocele.

Patients and methods

This was a randomized prospective study that reviewed all patients that presented to Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto, Nigeria, with myelomeningocele who met the inclusion criteria. Fifty-four patients were enrolled into the study randomized into two groups of 27 patients each. Group 1 had single-continuous repair, while group 2 had double-breasted technique. Post-operatively, patients were assessed for post-operative cerebrospinal fluid leak and pseudomeningocele. Data collected were analysed using the statistical package for social sciences version 22.0. The value for significance was set at 0.05.

Results

The median age at presentation for both groups was 5 months. Both groups showed female preponderance with a female-to-male ratio of 1.3:1 and 1.7:1. Post-operative CSF leak occurred in 2(7.4%) patients in the single-continuous group compared to 3(11.1%) patients in the double-breasted group. Only 1(3.7%) patient in the single-continuous group developed pseudomeningocele and none in the double-breasted.

Conclusion

Dural repair technique of myelomeningocele does not influence the occurrence of post-operative cerebrospinal fluid leak.
Influence of sport type and gender on bone turnover markers in young athletes
Authors: Apiloko Joy O. , Aje Oluwakayode S. , Awotidebe Taofeek O. , Okhawere Martin I. , Mbada Chidozie E. , Onyeso Ogochukwu K. , Idomeh Festus A. , Adagbusi Charles O. , Oke Kayode I.
Published: October 2023

Background

Exercise is beneficial to bone health. However, little is known about the interaction effect of gender and sport type on bone turnover in young athletes. This study aimed to examine the influence of gender and sports categories (high, medium, and low impact) on bone turnover: reabsorption markers–osteocalcin, calcium, inorganic phosphate (IP), alkaline phosphatase (ALP), and resorption marker–cross-linked N-telopeptides of type 1 collagen (NTx) among a university’s undergraduate athletes.

Methods

The study was an ex-post facto design involving forty-seven purposively recruited gender- and sport-type-matched undergraduate athletes whose demographic characteristics and BMI were obtained. Participants’ 5 mL antecubital blood samples were collected and analysed for serum levels of osteocalcin, calcium, IP, ALP, and NTx using standard laboratory protocols, Bio-Tek spectrometer, and KC4 (3.3) software. Data were analysed using descriptive statistics and two-way ANOVA.

Results

The study involved 24 females and 23 males (n = 47) aged 22.15 ± 3.35 years with an average BMI of 23.34 ± 4.66. There was no significant gender effect on the biomarkers. However, there was a significant effect of the sports category on IP (F = 4.307, p = 0.020), calcium (F = 6.807, p = 0.003), and ALP serum levels (F = 11.511, p < 0.001). Specifically, mid-impact sports participants had a higher IP than the low-impact group (mean difference [MD] = 0.81 mg/dL, p = 0.036). Low-impact had a higher calcium level than mid-impact (MD = 0.40 mg/dL, p = 0.022) and high-impact (MD = 0.49 mg/dL, p = 0.003). Conversely, low-impact had lower ALP than mid-impact (MD = − 11.13 U/L, p = 0.013) and high-impact (MD = − 17.44 IU/L, p < 0.001).

Conclusion

Moderate to high-impact sports positively affected bone turnover in young athletes. However, gender had no significant impact.
John Akomfrah's Vertigo Sea
Authors: Torlasco Domietta
Published: October 2023

A short essay on the life of images and sounds in John Akomfrah's Vertigo Sea; on radical montage as the reinvention of relationality and the index of errantry; and on ghosts and justice beyond equivalence.
Photography on Tilt
Authors: Michell Kalani
Published: October 2023

In 1968, after several disappointing years in Europe, where he wanted to trace his white aristocratic family tree, Frank Walter returns to his native Antigua and opens a photo studio. He didn't anticipate being seen in Europe as only Black, rather than mixed-race, and contemplates how to materialize this complex history. The studio was key for the one thousand two hundred fifty-plus miniature paintings he made before his death: he painted many of them on the back of studio photographs. To behold the relationship between the two sides of these images, one first has to suspend the knowledge claims and self-evident gestures that have relegated the photographic versos to static objects. One has to take hold of them — tilt, turn, and flip them. This article explores the overlooked role of contingency within the history of photography to reposition Walter's studio photographs/paintings as flip-objects. They do not just materially hold together aesthetic forms that are often epistemologically opposed to one another, inscribing studio photography, ephemera, blackness, and the Caribbean into Romantic painting, extant materials, whiteness, and Europe, for example. Rather, these works initiate a demand for reorientation, postulating that these different modes and media of visual representation can only be seen through one another, like a thaumatropic image.
Acute Coiling With Delayed Flow Diversion for Posterior Communicating Segment Internal Carotid Artery Aneurysms: A Multicenter Case Series
Authors: Enriquez Marulanda Alejandro , Young Michael , Shutran Max , Taussky Philipp , Kicielinski Kimberly , Ogilvy Christopher S.
Published: October 2023

BACKGROUND AND OBJECTIVES:

In ruptured posterior communicating artery (PcomA) aneurysms, the protection of the aneurysm dome alone with initial subtotal coiling decreases the risk of rerupture in the acute setting but does not provide durable/definitive long-term protection against delayed rupture. Delayed flow diverter (FD) placement can be a potential alternative to definitively secure these aneurysms without increasing the risk of complications and PComA occlusion. We analyzed PComA aneurysms treated with a planned delayed FD after primary coiling and assess radiographic and clinical outcomes.

METHODS:

We performed a retrospective study of prospectively collected data for intracranial aneurysms treated with planned FD at 2 institutions from 2013 to 2022. PComA aneurysms that underwent primary coiling and delayed FD placement were included for analysis.

RESULTS:

There were 29 PComA aneurysms identified that were included in the analysis. Patients were mostly female (79.3%), with a median age of 60 years. The mean aneurysm maximum diameter was 7.2 mm ± (5.3). Immediate Raymond-Roy occlusion grade after primary coiling was I in 48.3%, II in 41.4%, and III in 10.3% of aneurysms. The median time from initial coiling to planned delayed FD placement was 6.3 months (3.2-18.6). A total of 21 (72.4%) aneurysms underwent follow-up radiological imaging. Complete and near-complete occlusion status was achieved in 76.2% of the evaluated aneurysms. There were no retreatments and no evidence of delayed aneurysm rupture. One case (3.5%) presented thromboembolic complications and 1 (3.5%) intracranial hemorrhagic complication after FD placement, which was associated with mortality. Most patients (90.5%) had a modified Rankin scale of ≤2 on the last follow-up.

CONCLUSION:

Primary coiling with planned staged FD placement is effective for treating ruptured PComA aneurysms with high occlusion rates and low complications.
A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut
Authors: Oikonomou Panagiotis , Cirne Helena C. , Nerurkar Nandan L.
Published: October 2023

Although mechanical and biochemical descriptions of development are each essential, integration of upstream morphogenic cues with downstream tissue mechanics remains understudied during vertebrate morphogenesis. Here, we developed a two-dimensional chemo-mechanical model to investigate how mechanical properties of the endoderm and transport properties of fibroblast growth factor (FGF) regulate avian hindgut morphogenesis in a coordinated manner. Posterior endoderm cells convert a gradient of FGF ligands into a contractile force gradient, leading to a force imbalance that drives collective cell movements that elongate the forming hindgut tube. We formulated a 2D reaction-diffusion-advection model describing the formation of an FGF protein gradient as a result of posterior displacement of cells transcribing unstable Fgf8 mRNA during axis elongation, coupled with translation, diffusion and degradation of FGF protein. The endoderm was modeled as an active viscous fluid that generates contractile stresses in proportion to FGF concentration. With parameter values constrained by experimental data, the model replicates key aspects of hindgut morphogenesis, suggests that graded isotropic contraction is sufficient to generate large anisotropic cell movements, and provides new insight into how chemo-mechanical coupling across the mesoderm and endoderm coordinates hindgut elongation with axis elongation.
Crb3 is required to organize the apical domain of multiciliated cells
Authors: Burcklé Céline , Raitière Juliette , Michaux Grégoire , Kodjabachian Laurent , Le Bivic André
Published: October 2023

Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary epidermis of Xenopus laevis embryos, as they mature, dramatically reshape their apical domain to grow cilia, in coordination with the underlying actin cytoskeleton. Crumbs (Crb) proteins are multifaceted transmembrane apical polarity proteins known to recruit actin linkers and promote apical membrane growth. Here, we identify the homeolog Crb3.L as an important player for the migration of centrioles or basal bodies (collectively centrioles/BBs) and apical domain morphogenesis in MCCs. Crb3.L is present in cytoplasmic vesicles close to the ascending centrioles/BBs, where it partially colocalizes with Rab11a. Crb3.L morpholino-mediated depletion in MCCs caused abnormal migration of centrioles/BBs, a reduction of their apical surface, disorganization of their apical actin meshwork and defective ciliogenesis. Rab11a morpholino-mediated depletion phenocopied Crb3.L loss-of-function in MCCs. Thus, the control of centrioles/BBs migration by Crb3.L might be mediated by Rab11a-dependent apical trafficking. Furthermore, we show that both phospho-activated ERM (pERM; Ezrin-Radixin-Moesin) and Crb3.L are recruited to the growing apical domain of MCCs, where Crb3.L likely anchors pERM, allowing actin-dependent expansion of the apical membrane.
Waterborne amino acids: uptake and functional roles in aquatic animals
Authors: Griffin Robert A. , Glover Chris N. , McCuaig Jenelle D. , Blewett Tamzin A.
Published: October 2023

Dissolved organic matter is a ubiquitous component of freshwater and marine environments, and includes small nutrient molecules, such as amino acids, which may be available for uptake by aquatic biota. Epithelial transporters, including cotransporters, uniporters and antiporters, facilitate the absorption of dissolved amino acids (often against concentration gradients). Although there is a lack of mechanistic and molecular characterization of such transporters, pathways for the direct uptake of amino acids from the water appear to exist in a wide range of marine phyla, including Porifera, Cnidaria, Platyhelminthes, Brachiopoda, Mollusca, Nemertea, Annelida, Echinodermata, Arthropoda and Chordata. In these animals, absorbed amino acids have several putative roles, including osmoregulation, hypoxia tolerance, shell formation and metabolism. Therefore, amino acids dissolved in the water may play an important, but overlooked, role in aquatic animal nutrition.
Caffeine, CYP1A2 Genotype, and Exercise Performance: A Systematic Review and Meta-analysis
Authors: BARRETO GABRIEL , ESTEVES GABRIEL P. , MARTICORENA FELIPE , OLIVEIRA TAMIRES N. , GRGIC JOZO , SAUNDERS BRYAN
Published: October 2023

Purpose

This study aimed to summarize and meta-analyze existing evidence regarding the influence of CYP1A2 genotypes on the acute effects of caffeine for exercise performance and to investigate the interaction between genotype, dosage, and timing of caffeine supplementation.

Methods

Six databases were searched for studies determining the effect of caffeine (except mouth rinsing) on exercise performance between CYP1A2 genotypes. Three-level meta-analyses were performed using standardized mean differences (SMD; Hedge’s g) to determine the effect of caffeine on exercise outcomes within and between CYP1A2 genotypes (AA, AC, and CC). Meta-regressions were performed for dose, timing, and presence of reported conflict of interests (RCOI). A meta-analysis was also performed with placebo values to assess for imbalances between genotypes.

Results

Thirteen studies, totaling 119 outcomes and 440 participants, were included (233 AA, 175 AC, ad 34 CC). Caffeine improved performance for AA (SMD = 0.30, 95% confidence interval [CI] = 0.21–0.39, P < 0.0001) and AC (SMD = 0.16, 95% CI = 0.06–0.25, P = 0.022) but worsened performance for CC (SMD = −0.22, 95% CI = −0.44 to −0.01, P < 0.0001). Dose affected only CC, with greater doses generating more positive SMD (CC–dose estimate: +0.19/1 mg·kg−1 body mass, 95% CI = 0.04–0.33, P = 0.01). Timing influenced only CC, with better performance with later onset of exercise after supplementation (CC–timing estimate: +0.01/min, 95% CI = 0.00–0.02, P = 0.02). RCOI only affected SMD of CC (CC–RCOI estimate: −0.57, 95% CI = −1.02 to −0.12, P = 0.01). After excluding studies with RCOI, no influence of genotype was seen (all P ≥ 0.19). Small, nonsignificant differences were seen in placebo between genotypes (SMD AA vs CC: −0.13; AA vs AC: −0.12; AC vs CC: −0.05; all P ≥ 0.26).

Conclusions

Caffeine improved performance for AA and AC but worsened performance for CC. Dose and timing moderated the efficacy of caffeine for CC only. Caution is advised because baseline differences and studies with RCOI could have influenced these results.
The role of artificial intelligence in radiotherapy clinical practice
Authors: Landry Guillaume , Kurz Christopher , Traverso Alberto
Published: October 2023

This review article visits the current state of artificial intelligence (AI) in radiotherapy clinical practice. We will discuss how AI has a place in the modern radiotherapy workflow at the level of automatic segmentation and planning, two applications which have seen real-work implementation. A special emphasis will be placed on the role AI can play in online adaptive radiotherapy, such as performed at MR-linacs, where online plan adaptation is a procedure which could benefit from automation to reduce on-couch time for patients. Pseudo-CT generation and AI for motion tracking will be introduced in the scope of online adaptive radiotherapy as well. We further discuss the use of AI for decision-making and response assessment, for example for personalized prescription and treatment selection, risk stratification for outcomes and toxicities, and AI for quantitative imaging and response assessment. Finally, the challenges of generalizability and ethical aspects will be covered. With this, we provide a comprehensive overview of the current and future applications of AI in radiotherapy.
Analyzing the impact of loyalty card programs on customer behavior: insights from the Albanian market
Authors: Myftaraj Ervin , Trebicka Brunela
Published: October 2023

Background: Loyalty card programs have become prevalent in the retail industry, offering various benefits and rewards to customers. This study aims to analyze the impact of loyalty card programs on customer behavior in the Albanian market. Methods: A survey was conducted among a diverse sample of customers from different retail sectors in Albania. The survey collected data on awareness, satisfaction, loyalty, and customized benefits. The survey was distributed between March and May 2023, and responses were collected electronically. The survey responses were analyzed to address the research questions and test the hypotheses. Results: The findings indicate a significant level of awareness among respondents regarding loyalty card programs. Higher satisfaction with specific benefits, such as discounts and accumulating points, is associated with higher levels of customer loyalty. Customers who reported higher frequencies of loyalty card usage demonstrated greater loyalty. Customized benefits, particularly discounts and accumulating points, significantly influenced customer satisfaction. However, other benefit categories did not show statistically significant associations with loyalty. Conclusion: The study highlights the importance of promoting loyalty card programs to enhance awareness among customers. Improving and optimizing loyalty card benefits based on customer feedback is recommended. Encouraging frequent usage of loyalty cards and personalizing benefits to align with customer preferences are key strategies to foster customer loyalty. The findings provide valuable insights for practitioners in the retail sector to enhance customer engagement, satisfaction, and loyalty.
Cytotoxicity of dental cement on soft tissue associated with dental implants at different time intervals
Authors: Bajantri Prashanth , Rodrigues Shobha J. , Kabekkodu Shama Prasada , Bajaj Akshar , Hegde Puneeth , Mukherjee Sandipan , Saldanha Sharon , Mandatheje Mahesh , Shetty B Thilak , Pai Umesh Y. , Sales Ann , Kamath Vignesh
Published: October 2023

Background: To investigate and compare the effect of four commercially used dental cement at 24 hours, 48 hours,72 hours (h) and 6 days on the cellular response of human gingival fibroblast (HGF). Methods: 3 cement pellet samples were made for each 4-test cement (n=12). The cement used for this study were zinc phosphate (ZP), zinc oxide non-eugenol (ZOE), RelyX U200 (RU200), and glass ionomer cement (GIC). The cytotoxicity of peri-implant tissues was investigated using one commercial cell line. All processing was done following International Organization for Standardization (ISO) methods 10993-5 and 10993-12 (MTT assay Test). Cell cultures without dental cement were considered as control. Standard laboratory procedures were followed to permit cell growth and confluence over 48 hrs after sub-cultivation. Before being subjected to analysis, the cells were kept in direct contact with the cement samples for the suggested time period. To validate the results the specimens were tested three times each. Cell death and inhibition of cell growth were measured quantitatively. Results were analyzed using 1-way ANOVA (a=0.05) followed by Tukey B post hoc test. Results: The study showed the dental cement test material was cytotoxic. ZOE, ZP, GIC, and RU200 were cytotoxic in decreasing order, respectively, significantly reducing cell viability after exposure to HGF (p <0.001). Conclusions: Within the limitations of this in-vitro cellular study, results indicated that HGF were vulnerable to the test the dental cement. The highest cytotoxicity was observed in ZOE, followed by ZP, GIC, and RU200.
YCharOS open antibody characterisation data: Lessons learned and progress made
Authors: Biddle Michael S. , Virk Harvinder S.
Published: October 2023

YCharOS is a collaborative initiative aimed at characterising antibodies against the entire human proteome. As of August 2023, they have presented comprehensive knockout characterisation data for 812 antibodies and 78 proteins using techniques such as Western blot, immunoprecipitation, and immunofluorescence. YCharOS consolidates its data into reports (one protein per report) available on Zenodo, a public repository controlled by CERN, to ensure open access. To enhance the visibility of their work, the group is progressively converting their Zenodo reports into F1000 articles, collected on the YCharOS Gateway, and indexed via PubMed. Their data is also accessible through searches on the Antibody Registry. The provided data is a valuable resource for researchers when selecting antibodies for specific applications, although certain limitations should be considered. The data accumulated thus far has illuminated the extent of the problem when poorly performing antibodies are employed in research. While the scientific community was already aware that this was likely a widespread issue, the establishment of a collaborative open science project with industry partners introduces an innovative solution that holds the potential to yield significant returns on investment in the public interest. This potential is substantiated by the number of antibodies that have either been withdrawn or had their recommended usage altered by the vendor. However, despite the discovery of high-performing renewable antibodies for most of the studied proteins, this accounts for a tiny fraction of the human proteome and the commercial antibody market. To realise the full potential of this work, end-users must adjust their antibody procurement and usage practises in line with the provided data. This editorial offers a guide on how individual scientists can utilise the YCharOS data, in addition to sharing the insights gained from the data thus far with the wider scientific community.
Soil chemistry: a practical course
Authors: Mamontov Vladimir
Published: October 2023

The textbook describes methods for analyzing the elemental composition of the mineral part of soils, ways to express the results of gross analysis and recalculation of analytical data. Methods for studying the ion-salt complex of soils and available forms of plant nutrition elements, as well as methods used to determine the total humus and nitrogen, group and fractional composition of humus, and methods for studying some properties of humic acids are presented. The use of gross analysis data, the results of studying the ion-salt complex and soil organic matter for practical purposes is considered.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is addressed to students of higher educational institutions studying at the faculties of soil Science, agrochemistry and ecology in the field of training "Agrochemistry and agro-soil science", as well as graduate students and researchers specializing in soil science, agrochemistry, ecology and agronomy.
History of architecture of world confessions
Authors: Il'vickaya Svetlana
Published: October 2023

The textbook discusses the features of the cult architecture of a number of Eastern countries. These are architectural monuments, the main types of temples, as well as the style trends of the main denominations of India, China, Japan, the region of Southeast Asia, Arab-Muslim countries, the Orthodox East, etc. The problem of cultural interaction between the West and the East in the context of architectural science and globalization in architecture is presented.
It contains not only a theoretical part, but also a practical one, including the methodology for performing analytical work on this course, methods of architectural research of monuments, topics of scientific abstracts aimed at in-depth assimilation of theoretical material, as well as lists of recommended literature. The textbook completes the thesaurus of architectural terms.
Meets the current requirements of the Federal State Educational Standard of Higher Education.
For students of educational institutions of higher education — future architects, designers and art historians, for students studying related disciplines: urban planning, cultural studies, art history, design, etc., as well as for graduate students and teachers of architectural faculties and universities. It can be useful to all those who are interested in architectural monuments of world confessions.
Innovation management
Authors: Chursin Aleksandr , Abueva Milana
Published: October 2023

The textbook is a comprehensive study of the development of the modern theory of innovation management. The fundamentals of the development of the general theory of innovation activity, the regulatory framework defining innovation activity at the present stage are outlined, the process of formation of innovative competencies is considered, the analysis of the main tools of innovation management, including innovative projects, is carried out. The methods of risk assessment in innovation activity are given and the issues of their management are considered. A distinctive feature of the textbook is the systematization and generalization of material in the areas of "Innovation Management", "System analysis", "Project Management" for multi-level analysis of innovation activity.
Meets the current requirements of the Federal State Educational Standard of Higher Education.
For students, undergraduates, postgraduates, teachers of economic universities and specialists dealing with innovation management.
Integrated object management information systems. Corporate information systems
Authors: Grigor'ev Anatoliy , Isaev Evgeniy , Kornilov Vasiliy , Morgunov Aleksandr , Tarasov Pavel
Published: October 2023

The textbook discusses the most popular object management systems in business, providing the possibility of collective work of users united by common business processes, goals and objectives of production activities. It contains a description of management systems of various classes of corporate information systems, their functions, structure, classifications, features of application and implementation in the activities of enterprises.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the areas of training: 09.03.02 "Information systems and technologies", 38.03.02 "Management", studying disciplines: "Corporate information systems" and "Information systems in marketing", as well as for students of economic specialties, specialists.
State regulation of entrepreneurial activity in conditions of geopolitical instability
Authors: Shatohin Mihail , Vasil'eva Oksana , Zhahov Nikolay , Hokonov Anzor , Novosel'skiy Svyatoslav , Antropova Tat'yana , Alauhova Ol'ga , Zubkov Maksim
Published: October 2023

The issues of business regulation have long been key problems in our country, the solution of which to a strictly necessary extent was a prerequisite for increasing the pace of economic development.
The monograph examines the features of state regulation of entrepreneurial activity in the modern realities of the Russian economy, identifies key problems and obstacles to the implementation of activities by small and medium-sized businesses under the conditions of sanctions pressure. Particular attention is paid
to the impact of the tax burden on the effectiveness of the current model of the economy, state regulation of social and youth entrepreneurship.
It is intended for a wide range of scientific and practical workers, specialists of management bodies, entrepreneurs and other interested persons.
Parenting of children and youth: trends and solutions
Authors: Ivanova Irina , Makarova Valentina , Astahova Lyubava , Buslaeva Mariya , Gur'eva Vera , Portnova Ol'ga
Published: October 2023

The monograph is devoted to a problem that has aroused the interest of mankind at all times and is of particular relevance in the light of modern trends in the development of society, science, and education — the problem of raising children and youth.
Various aspects of education in the conditions of educational organizations of general, additional and higher education are considered, their leading tendencies and educational opportunities are determined.
It is intended for teachers, educational psychologists, social educators, organizers of work with youth, parents.
Comparative History of Foreign Law in 2 tt.
Authors: Poldnikov Dmitriy
Published: October 2023

The second volume of the textbook is devoted to the transformation of the leading legal traditions in the conditions of modernization, the transformation of agrarian societies into industrial ones, the emergence of nations and national states. It examines the formation and development of the most influential national legal traditions of England (Great Britain), the USA, France and Germany, which determined the models and legal style of Western law. The legal modernization of Japan, China, India, and the Middle East countries is presented as a result of reception and adaptation of elements of Romano-German, Anglo-American, and Soviet law in the context of Eastern traditions.
The textbook meets the requirements of the Federal State Educational Standard of Higher Education and the educational standards of MGIMO of the Ministry of Foreign Affairs of Russia in the field of "Jurisprudence".
For undergraduate, graduate, postgraduate students and teachers of law schools and faculties of Russia and CIS countries.
Возвращение в Острог Саши Филипенко: деформация зазеркалья в романе-созерцании «русской тоски»
Authors: Kliabanau Dzmitry
Published: October 2023

Powrót do Ostroga Saszy Filipenko: deformacja i wykrzywienia świata po drugiej stronie lustra w powieści-kontemplacji «rosyjskiej tęsknoty»
Powrót do Ostroga Saszy Filipenko – jeden z przykładów funkcjonowania w literaturze postmodernistycznej powieści kontemplacyjnej skupiającej się na wszechstronnym spojrzeniu na rzeczywistość bez jej oceniania. Powieść cechuje heterogeniczność gatunkowa: w opartym na realnych faktach Powrocie do Ostroga obecne są wątki powieści detektywistycznej, powieści grozy, satyry politycznej. Elementem kluczowym narracji staje się wpatrywanie w odwieczną rosyjską tęsknotę – na poziomie fizycznym, materialnym, ale przede wszystkim mentalnym i duchowym. Owa wszechobecna tęsknota staje się wręcz jednym z bohaterów powieści.
Świat Ostroga – postmodernistyczne reminiscencje do Hamleta Shakespeare’a i Wspomnień z domu umarłych Dostojewskiego. Jest to świat wywrócony, zdeformowany – zwierciadło odbijające mentalną i duchową kondycję współczesnego społeczeństwa rosyjskiego. Motyw deformacji i rzeczywistości po drugiej stronie lustra jest realizowany w utworze za pomocą wielu symboli. Sercem Ostroga, wokół którego to miasto się rozrosło, jest więzienie, którego odbiciem właściwie staje się sierociniec. Z kolei semantyczne obciążenie obecnego w tytule wyrazu „powrót” jest uosobieniem ruchu spiralnego historii nie tylko Ostroga i jego mieszkańców, lecz, w gruncie rzeczy, całego społeczeństwa rosyjskiego.
Wspomnienie o podporuczniku Bronisławie Trybusie żołnierzu 1. Polskiej Dywizji Pancernej
Authors: Mazur Łukasz
Published: October 2023

Brak
Transmodernidad e hipermodernidad. Apuntes sobre la vía arcaica en Japón.
Authors: Fernández Roberto
Published: October 2023

El sentido que toma la modernidad en Japón como exaltación de lo moderno, el triunfo del liberalismo económico y el hipertrófico desarrollo tecnológico conectan, según el autor, con las prácticas -cotidianas y artísticas- y estructuras socioeconómicas de su pasado ancestral. La exaltación de la forma sensible de la subjetividad y la autorreferencia de la técnica, como componentes de su cultura arquetípica, constituyen los antecedentes de la construcción del paisaje japonés contemporáneo, caracterizado por el dominio de lo objetual, la dicotomía objeto-contexto, el caos sígnico y el ilusionismo virtual.
El diseño arquitectónico como medida de calidad: postfolio.
Authors: Maldonado Tomás
Published: October 2023

Ante la confusión en los criterios de establecer una valoración objetiva de las cosas, Tomás Maldonado introduce un análisis del concepto de calidad en que plantea cuestiones como la posibilidad de una matemática cuantificación generalizada de las cualidades, el debate entre determinismo y relatividad de los valores y el concepto de «cualidad dinámica» como posibilidad de englobar los conceptos de tolerancia y objetividad.
The veterinary nurse's diagnostic assessment of the small animal cardiac patient
Authors: Pace Charlotte
Published: October 2023

Veterinary nurses play an important role in small animal practice. This article covers the diagnostic assessment that a nurse may perform on a small animal cardiac patient, from the physical examination to blood tests and advanced imaging. Cardiac patients can present in a variety of situations, including chronic conditions and acute emergencies. The veterinary nurse must be able to work with these patients in a calm manner to prevent creating any additional stress, and must also know when they should refer to a veterinary surgeon.
Prioritising holistic well-being in early years education
Authors: Lewin Lucy
Published: October 2023

Lucy Lewin, founder and CEO of The Profitable Nursery Academy, discusses how to create an environment which fosters holistic well-being for both children and staff in early years settings.
Remembering the forgotten: Why is the gap between looked-after children and their peers not being addressed?
Authors: Gillespie Emma
Published: October 2023

Studies into factors affecting the social and emotional development of children across the globe exist in bountiful numbers, but the amount of research into the early years of children living in social care placements continues to decline. The impact that being a looked-after child (LAC) can have on development is specific, yet not understood to the extent it could be. Why? Emma Gillespie, early years educator explores this further in the second article of the series.
Working together is the only way to drive political ambition for early education
Authors: Ronan Sarah
Published: October 2023

Earlier this summer leading organisations and charities came together to form the Early Education and Childcare Coalition (EECC) to lobby the government and all political parties to prioritise early years education and childcare at the next general election. Sarah Ronan, acting director, outlines her hopes for the new coalition and what she would like the government to do to tackle the challenges facing the sector.
Prioritising staff well-being will allow children to thrive
Authors: Wright Caroline
Published: October 2023

Caroline Wright, director of Early Childhood at Bright Horizons, explains why supporting adults is key to being able to effectively support children.
Diagnosis and management of cellulitis in a primary care setting
Authors: Perry Margaret
Published: October 2023

Margaret Perry looks at what nurses need to known about this common skin infection
Treating young patients with cosmetic botulinum toxin and hyaluronic acid dermal fillers
Authors: Kelso Kate , Bell Tracey
Published: October 2023

There has been a huge rise in the number of young patients seeking aesthetic treatments in recent years. This article examines the pressures on and motivations of young patients to seek treatment, the ethics surrounding their treatment and specific considerations for the practitioner providing botulinum toxin and hyaluronic acid filler to this particular cohort of patients
A Comprehensive Review on Zebrafish and Zebrafish Embryonic Stem Cells (Zescs) as the Versatile Biotechnological Green Tool for Detecting Environmental Pollutants
Authors: Christy.L Divya , Nellore Jayshree
Published: October 2023

This article discusses the embryonic development of zebrafish, which are essential aquatic models for investigating neurotoxicity caused by environmental toxins. Zebrafish are one of the few fish species that can survive in highly toxic environments, making them an interesting model for assessing pollutants' performance and determining their toxicity. Zebrafish's limited life expectancy, ease of maintenance and growth, transparent embryos, and homology of genetic and biological features make them an interesting tool for studying the effects of common substances like insecticides, nanoparticles, and food supplements on human health. The study focuses on the regulation of morphology and behavior, stress caused by oxidative damage, transcription, neurogenesis, and neuron progression. Further research is needed at cellular and signaling levels to understand the detrimental processes of pollutants in relation to epigenetic toxicity, negative interference of the BB barrier, and manipulation of the brain-gut-microbiota axis. Environmental pollution is a significant issue that poses a severe threat to public health. Biotechnological principles are now being widely used to monitor environmental pollutants due to their versatile applications. In this regard, zebrafish has established as a prominent vertebrate prototype organism, which offers a unique platform for toxicity screening and efficacy testing of various chemicals. Studies have shown that exposure to toxicants during embryonic development can cause developmental, cardiovascular, and neurodevelopmental toxicity, as well as hepatic disorders in zebrafish. Therefore, zebrafish has been extensively used to study the neurotoxicity of environmental pollutants, including pesticides, nanoparticles, food additives, and other pollutants. Additionally, the review discusses the use of zebrafish-derived embryonic stem cells (ZESCs) for environmental pollutants monitoring. Stem cells are highly sensitive to the toxicity of environmental chemicals during embryogenesis, which can lead to adverse effects on embryonic and fetal development. Thus, ZESCs cultivation and utilization in toxicological assays have become a valuable tool for evaluating the toxicity of potential environmental toxicants. The application of green science principles to evaluate the toxicity of environmental pollutants using zebrafish and ZESCs has enormous potential. This approach offers a sustainable and environmentally friendly way to monitor pollutants, and it can contribute to the development of effective mitigation strategies. Overall, the use of zebrafish and ZESCs in biotechnological pollutants monitoring could have far-reaching effects for public health and environmental sustainability.
18S rRNA Approach for Identification of Chara L. Species
Authors: Adimulam Rekha , Sujathamma P
Published: October 2023

The study focused on the molecular phylogenetics for the identification of genus Chara species through 18S rRNA genes. Genus Chara sample is collected in the freshwater streams of Talakona region, Chittoor district, Andhra Pradesh and DNA was isolated. The 18S rRNA, gene sequence was used to carry out BLAST with the ‘nr’ database of NCBI GenBank database. First ten sequences were selected based on maximum identity score using multiple alignment software program Clustal W. Ribosomal Database Project was used for generating distance matrix and Molecular Evolutionary Genetics Analysis 6 Software was used for constructing the phylogenetic tree. Based on the maximum identifying score Chara species was identified as Chara foetida.
The Witness to an Informed Consent for Surgery/Invasive Procedure: The Ethical and Legal Aspects
Authors: Pai Satvik N , Jeyaraman Madhan , Jeyaraman Naveen , Shyam Ashok
Published: October 2023

Informed consent is an exercise to protect the right of the patient to make an informed decision regarding his/her willingness to undergo a procedure. The doctor needs to explain all aspects of the procedure to the patient beforehand, including the nature of the procedure, its purpose, alternatives, and possible complications. The patient’s signature is required on a written informed consent to document their willingness for the procedure. It is required by law that such an informed consent be obtained from every patient undergoing any invasive procedure. However, the role of a witness for the informed consent is ambiguous. This brings up certain important questions regarding the witness for an informed consent – is it necessary? And if so, who should be a witness? These questions have been largely been unexplored and unanswered. There is scarce literature regarding the requirement and role of a witness for an informed consent before an invasive procedure/surgery. The supreme court of India, even in its landmark judgment on the requirements of informed consent, did not address the role of a witness for the consent. While it laid down the guidelines for a valid informed consent and explained the contents to be present in an informed consent, it made no mention of requiring a witness to be present at the time of obtaining such consent [1].
Permanent Resection Arthroplasty of the Knee as Limb Salvage Following Recurrent Periprosthetic Infection Complicated with Osteomyelitis
Authors: Razii Nima , Morgan-Jones Rhidian
Published: October 2023

Introduction: Permanent resection or excision arthroplasty of the knee involves the removal of any infected prosthetic material and thorough debridement, with no further reimplantation. The more common alternatives to permanent resection arthroplasty include knee arthrodesis or above-knee amputation (AKA). Case Report: We describe two cases of complex periprosthetic infections of the knee associated with subsequent osteomyelitis, which were unsuitable for re-revision arthroplasty. Both patients chose to remain with an excision arthroplasty, rather than undergo arthrodesis or AKA, respectively, and were satisfied with their quality of life at long-term follow-up. Conclusion: Although permanent resection arthroplasty of the knee is rarely performed, it remains a limb salvage option in certain cases where bone loss is limited, functional demands are low, and further surgery may present a significant risk. Keywords: Knee, resection arthroplasty, excision arthroplasty, revision, periprosthetic infection, osteomyelitis, limb salvage.