bluuebunny/crossref_metadata_2025 huggingface dataset:
Comentario a la nueva Ley catalana de protección y ordenación del litoral
Authors: Ros Arpa Carlos
Published: September 2023

La Ley catalana 8/2020, de 30 de julio, de protección y ordenación del litoral, tiene como objetivo principal la gestión integrada de las competencias de las tres administraciones públicas implicadas. La Ley alcanza este objetivo de forma satisfactoria en el reparto competencial entre Generalitat y ayuntamientos, a través de las dos figuras que tienen que desarrollar su aplicación: el Plan de protección y ordenación del litoral y los planes de uso del litoral y de las playas. Este objetivo no se logra en las relaciones entre la Administración del Estado y la Generalitat. Queda sin resolver el desequilibrio entre la Administración que recauda la mayoría de los ingresos procedentes del DPMT y la Administración que asume buena parte de competencias ejecutivas sobre el mismo. El nuevo canon que graba la explotación de actividades que requieren una concesión de la Generalitat ha de tener un alcance limitado. En términos generales, habría que garantizar que los ingresos derivados de los cánones por la ocupación o el aprovechamiento del DPMT se destinasen efectivamente a la mejora, conservación, recuperación y restauración del dominio público del propio territorio donde se produce la ocupación grabada.
Notas de la Ley de Cambio Climático
Authors: López Ramón Fernando
Published: September 2023

Aplicando criterios de relevancia jurídica, se identifican las siguientes notas características de la Ley 7/2021 de Cambio Climático: complejidad en su elaboración y formulación, establecimiento de precisas obligaciones de resultado, previsión de amplios poderes del ejecutivo, escasa participación autonómica, inclusión de medidas financieras y limitados contenidos reguladores. Todo lo cual lleva a plantear el interrogante de si concurría el grado de necesidad y oportunidad que justificaría la aprobación misma de la nueva Ley.
Delimitación entre contrato, convenio y subvención
Authors: Sibina Vidal Carme
Published: September 2023

Los contratos, los convenios y las subvenciones son tres negocios jurídicos que no siempre son fáciles de distinguir, porque comparten varios elementos (mismas partes, realización de una actividad de interés general y transferencia de fondos públicos). Ahora bien, la elección del tipo de negocio que es aplicable a un supuesto concreto no está a disposición de las Administraciones públicas. Al contrario, la finalidad, los derechos y las obligaciones de las partes son los que definen la naturaleza del negocio jurídico que debe elegirse y, en consecuencia, el régimen jurídico aplicable, de modo que el estudio de estos elementos nos permite delimitar el ámbito propio de cada uno de ellos. El presente estudio se centra en el análisis de estostres negociosjurídicos, delimitando el ámbito de cada uno de ellos, buscando herramientas para distinguirlos y formulando una serie de recomendaciones para establecer, en cada caso concreto, si estamos ante un contrato, un convenio o una subvención.
Aclaración y subsanación de las ofertas en los contratos del sector público
Authors: Gris González Juan Carlos
Published: September 2023

El trabajo analiza la problemática derivada de la aclaración o subsanación de las imprecisiones o errores de las ofertas formuladas por los licitadores. Este análisis se ha efectuado desde un punto de vista eminentemente práctico y pensando en el aplicador del derecho, de ahí que se hayan tomado como referencia los pronunciamientos que han emanado al respecto de los diversos órganos judiciales y administrativos.

Asimismo, el estudio se centra en la corrección de los errores que aparecen en la documentación técnica y económica de los licitadores, ya que es este el campo donde se generan las mayores incertidumbres jurídicas.
Negociación colectiva y función pública local
Authors: Mauri Majós Joan
Published: September 2023

El análisis se ha concebido como una puesta al día y revisión de los últimos estudios publicados sobre la negociación de las condiciones de trabajo en el empleo público que toman como referencia principal el ámbito específico de la Administración local, prestando una especial atención a la clarificación de aquellos aspectos de mayor importancia que pudieran ser objeto de consideración en la práctica convencional propia de nuestras entidades territoriales, como pudieran ser los atinentes a la estructura y el ámbito de la negociación, el procedimiento convencional y el tratamiento de la naturaleza y eficacia de los acuerdos colectivos.
La incompatibilidad del artículo 178.2.b) LOREG entre los cargos de concejal y empleado de una misma entidad local: una difícil ponderación de intereses constitucionales
Authors: Clemente Martínez Jaime
Published: September 2023

El régimen de incompatibilidades de los cargos electos locales, y en especial el del artículo 178.2.b) LOREG, es uno de los ámbitos de gran conflictividad constitucional, fruto de la numerosa casuística propia de los ayuntamientos. Ello es consecuencia de la afectación del artículo 23 de la Constitución a esta prohibición, que ha hecho que la jurisprudencia y la Junta Electoral Central hayan establecido un elenco de requisitos que excepcionan este precepto. De este modo, analizaremos los condicionantes que permiten compatibilizar el puesto de concejal con el de personal del propio consistorio, donde se debe realizar una difícil ponderación de intereses constitucionales que, hoy en día, todavía no es pacífica y exige de un desarrollo para mayor protección de los derechos constitucionales afectados. Estos son el referido artículo 23 de la Constitución, que permite la participación política, y el artículo 103 de la Constitución, que trata de evitar conflictos de intereses al garantizar la objetividad y el interés general en las entidades locales españolas.
Los procedimientos de reacción frente a la contratación menor irregular y los efectos de la invalidez del contrato menor
Authors: Sesma Sánchez Begoña
Published: September 2023

La depuración de la contratación menor irregular puede realizarse a través de distintos cauces cuyo régimen jurídico (causas, procedimiento, plazos) y efectos económicos difieren notablemente, y sobre los que existe una amplia disparidad de criterios doctrinales, consultivos y jurisprudenciales. El trabajo analiza las vías de la reclamación judicial de pago con fundamento en la prohibición de enriquecimiento injusto, el reconocimiento extrajudicial de la obligación y la convalidación de gastos anulables, la revisión de oficio de la contratación menor nula de pleno derecho, la responsabilidad patrimonial y la contractual, así como los respectivos efectos derivados de la invalidez del contrato menor.
The many faces of hydrogeology
Authors: Rossetto Rudy
Published: September 2023

Not available
Overcoming the nutritional immunity by engineering iron scavenging bacteria for cancer therapy
Authors: Huang Sin-Wei , Lim See-Khai , Yu Yao-An , Lien Wan-Ju , Mou Kurt Yun
Published: September 2023

Certain bacteria demonstrate the ability to target and colonize the tumor microenvironment, a characteristic that positions them as innovative carriers for delivering various therapeutic agents in cancer therapy. Nevertheless, our understanding of how bacteria adapt their physiological condition to the tumor microenvironment remains elusive. In this work, we employed liquid chromatography-tandem mass spectrometry to examine the proteome of
E. coli
colonized in murine tumors. Comparing to
E. coli
cultivated in the rich medium, we found that
E. coli
colonized in tumors notably upregulated the processes related to ferric ions, including the enterobactin biosynthesis and iron homeostasis. This finding indicated that the tumor is an iron-deficient environment to
E. coli
. We also found that the colonization of
E. coli
in the tumor led to an increased expression of lipocalin 2 (LCN2), a host’s protein that can sequester the enterobactin. We therefore engineered
E. coli
in order to evade the nutritional immunity provided by LCN2. By introducing the IroA cluster, the
E. coli
synthesizes the glycosylated enterobactin, which creates steric hindrance to avoid the LCN2 sequestration. The IroA-
E. coli
showed enhanced resistance to LCN2 and significantly improved the anti-tumor activity in mice. Moreover, the mice cured by the IroA-
E. coli
treatment became resistant to the tumor re-challenge, indicating the establishment of immunological memory. Overall, our study underscores the crucial role of bacteria’s ability to acquire ferric ions within the tumor microenvironment for effective cancer therapy.
Visual design of green information in urban environment based on global similarity calculation and multi-dimensional visualization technology
Authors: Wang Junru
Published: September 2023

In recent years, the escalating prevalence of elevated consumption and carbon emissions within urban operations has reached a disconcerting extent. This surge in resource depletion and environmental pollution exerts an adverse influence on the well-being of individuals, while impeding societal progress and hindering the enhancement of overall quality of life. Within the domain of urban environmental design, the integration of visual displays emerges as a superior approach to facilitate the assimilation and analysis of green and low-carbon information. However, urban environmental data usually contains multiple dimensions, so it is a problem to realize the data representation of multiple dimensions while maintaining the correlation and interactivity between data. To surmount the challenge of visualizing such intricate information, this investigation initially employs a sophisticated memory-based clustering algorithm for information extraction, accompanied by a global similarity algorithm that meticulously computes attribute component quantities within specific dimensions of the vector. Furthermore, leveraging the inherent power of Vue’s bidirectional data binding capabilities, the study adopts the esteemed MVVM (Model-View-View-Model) pattern, fostering seamless two-way interaction through the established logical relationship. As a result, the amalgamation of multidimensional visualization technology empowers comprehensive data mining through a captivating visual augmentation. Concurrently, the application of data visualization dimension control delivers tailored displays tailored to green and low-carbon scenarios within urban environmental design. Experimental results impeccably validate the effectiveness of the proposed algorithm, substantiated by a mere 1.77% false alarm rate for data stream difference detection and a clustering difference of 1.34%. The aforementioned algorithm accentuates the efficacy of visual displays, thus engendering a profound synergy between the industrial and supply chains. Moreover, it facilitates the design, production, and utilization of environmentally friendly products and energy sources. This, in turn, serves as a catalyst, propelling the widescale adoption of green and low-carbon practices throughout the entire industrial chain, fueled by the seamless integration of multimedia data.
Literature review: influential factors on graduate professor’s performance
Authors: Teixeira Tatiane , Picinin Claudia Tania , Pilatti Luiz Alberto , Moletta Juliana , Serpe Luís Filippe
Published: September 2023

This paper aims to conduct a review of the literature to map the factors that influence the professor's performance of graduate programs. The methodology consists of researching studies from 2008 to 2018 in the Scopus and Web of Science databases, using the keywords: performance, professor and graduate. The contributions of this study are: creation of a framework with the concept of professor’s performance addressing several authors and the creation of 8 categories. The results show factors that influence professor’s performance according to the mapped literature, categorized into pedagogical, scientific and didactic performance, teacher training, teaching method, pedagogical updating, health, knowledge management, students' perspective and scientific production, with 32% of studies related to research productivity standing out. This research contributes to highlight the work developed by professors and the factors presented help to develop strategies to facilitate the work of the professor and promote better performance.
Implantação do processo de sucessão em uma empresa familiar de transportes: desafios e contradições
Authors: De Almeida Edson Rodrigo , Melo Marlene Catarina de Oliveira Lopes Melo
Published: September 2023

Este artigo apresenta uma pesquisa denominada “Estado do Conhecimento” sobre a temática “Ensino Híbrido”. Objetiva encontrar subsídios teóricos para um novo estudo, no sentido de não só compreender melhor a temática, como também buscar auxílio para decisões metodológicas de uma pesquisa maior.  As buscas foram realizadas nas plataformas BDTD e Google Scholar, a partir do termo indutor “Ensino Híbrido”. Após a utilização de alguns filtros, dentre eles o recorte temporal entre 2015 e 2020, foram encontradas 415 produções e destas foram selecionadas 21 para compor o corpus do “Estado do Conhecimento”. Os resultados mostram que a maioria das pesquisas associa o ensino híbrido à formação de professores, considerando o desenvolvimento de habilidades ligadas às tecnologias de informação.  Assim, tanto a formação de professores quanto as habilidades para lidar com as tecnologias passam a ser questões norteadoras para a pesquisa maior.
The Survival Rate and Growth of Grafted-Seedling of Durian (Durio zibethinus Murr.) Using 3 Rootstocks Ages and 3 Levels of Scion Buds
Authors: Asmawati  , Inderiati Sitti , Hambali Amriani
Published: September 2023

This experiment was performed to determine the survival rate of grafted-seedling growth of durians using various ages of rootstocks and different numbers of scion buds. The study was arranged in a two-factorial randomized block design with three replications. The first factor was rootstock age (4, 6, and 8 weeks) and the second factor was the number of buds on the scion (1, 2, and 3 buds).  The percentage of the successful grafting and several growth parameters, i.e., time of bud break, length and diameter of new shoots were evaluated for three months. Data were analysed using analysis of variance and continued with the post-hoc Tukey’s test. The results showed that age of rootstock did not affect percentage of successful grafting, time of budburst, shoot length and shoot diameter. Likewise, the number of shoots did not affect the percentage of successful grafting, shoot length, and shoot diameter, but had a significant effect on bud bursting time (P<0.05). Scion that had three buds resulted in the fastest time of bud break (28.45 days).  The highest percentage of successful graft union was in the 4-week-old rootstock and scion with 2 and 3 buds (100%), the maximal successful also obtained in the 6-week-old rootstocks with 3 buds. The four-week-old rootstocks also gave the best result in the new shoot length and diameter.  Nevertheless, there was no interaction between rootstock age and the number of buds on scion in survival rate of grafted seedlings of durian.
Application of Artificial Neural Networks in Polymer Composites: A Review
Authors: Niu Jiale , Zhang Yingying
Published: September 2023

Artificial neural networks (ANN), which have been a hot topic in the field of artificial intelligence (AI) since the 1980s, are widely applied these years for their strong ability in the field of nonlinear mapping, pattern recognition, robots, automatic control, biology, economy and so on. This review presents and summarizes the history of artificial neural networks, briefly introducing the application of artificial neural networks. After that, the paper focuses on an overview of research advances in neural networks for polymer composites and introduces several classical categories of applications. Finally, we look ahead to the development of neural network applications in polymer composites and provide a future outlook for the application of artificial neural network in polymer composites.
Infrared Thermometry Studies for Estimation of Crop Water Stress Index
Authors: Sajjan Preeti , Ramana M. V. , Krupavathi K. , Sumathi P.
Published: September 2023

An IR thermometry enables non-contact temperature measurements of the crop canopy, capturing infrared radiation emitted by objects without physical contact, which is beneficial for accurate Crop Water Stress Index (CWSI) estimation as it minimizes interference and temperature reading alterations. In this study, handheld IRT was used to measure the canopy temperature of selected crops in 32 farms, 8 each in crop of Maize, chilly, groundnut and Black gram which were predominantly grown in Bapatla and Prakasm districts. Canopy temperature (Tc) and temperature of non-water stressed crop (Tnws) were measured 4 times during the Rabi season on clear sky days. The results concluded that at the initial stage, crops were grown with residual moisture of Kharif paddy hence at that stage CWSI values were low. The highest CWSI in the season was observed for the crop black gram about 0.524 and the lowest was observed for the crop chilly about 0.245. The seasonal average CWSI values for Maize, Chilly, Groundnut and Black gram were 0.382, 0.323, 0.358 and 0.399, respectively. CWSI determination helps to monitor the crop stress level, by knowing it, it is easy for irrigation scheduling by taking a threshold CWSI value to start irrigation. The average CWSI for each crop can be taken as a threshold value for irrigation scheduling.
Path Coefficient Analysis for Yield and Its Attributing Traits in Wheat (Triticum aestivum L.)
Authors: Kumar Rohit , Singh S. K. , Bagare Vijay , Singh Artee , Pathak Vijya Nand , Yaday Vikash , Kumar Rohit
Published: September 2023

The experiment was carried out during rabi 2019-2020 at Crop Research Farm, Nawabganj of C.S. Azad University of Agriculture and Technology Kanpur, Uttar Pradesh (INDIA) for experiment. The experimental materials comprised of 100 treatments including 10 diverse parents, 45 F1s and 45 F2s were planted in randomized complete block design with three replications. Path analysis considered one of the best statistical methods which can help breeders to characterize the crop populations during the parent selection program and select the desirable genotypes for higher yield production. Path coefficients analysis showed that biological yield per plant has maximum and positive direct effect on grain yield per plant followed by number of tillers per plant at phenotypic level. Harvest index, plant height, seed hardness, tryptophan content, number of seed per spike and 1000 grain weight per plant had also positive direct influence on grain yield per plant. Rest of the traits has negative direct influenced grain yield per plant.
Feridas complexas de membros inferiores por desenluvamento cutâneo pós-traumático raro durante a pandemia da COVID19 no centro-oeste brasileiro
Authors: Moura Brenner Dolis Marretto de , Mendes Neto Ivam Pereira , Macedo Jefferson Lessa Soares de , Canedo Lucas Ribeiro , Silva Lucio Marques da , Reis Vitoria Pereira
Published: September 2023

Introdução: a reconstrução de membros inferiores (MMII) decorrente do trauma é um dos maiores desafios da Cirurgia Plástica. Com retorno das atividades após a pandemia da COVID-19, foi possível observar um aumento nas taxas de internação por acidentes de trânsito, aumentando também as internações por feridas complexas de MMII. Este estudo tem como objetivo apresentar um caso raro de feridas complexas de MMII por desenluvamento cutâneo traumático. Relato de Caso: paciente masculino, 29 anos, sem comorbidades prévias, foi admitido no Serviço de Cirurgia Plástica do Hospital Regional da Asa Norte por ferimentos complexos em MMII, após acidente motociclístico no qual houve colisão entre a moto do paciente e um ônibus. Ele foi submetido a tratamento clínico otimizado e a dez desbridamentos cirúrgicos e curativos, incluindo a modalidade a vácuo. O paciente evoluiu com melhora do aspecto da lesão e, em seguida, passou por mais duas cirurgias para autoenxertia de pele. Recebeu alta hospitalar após cento enove dias de internação e foi encaminhado para seguimento ambulatorial interdisciplinar. Discussão: as lesões traumáticas de MMII ocorrem, principalmente, em adultos jovens, do sexo masculino, vítimas de acidentes envolvendo motocicletas, entre a segunda e a terceira décadas de vida. O manejo de feridas complexas requer tratamento clínico e/ou cirúrgico. No que se refere ao tratamento cirúrgico, há diversas técnicas, devendo-se optar, sempre que possível, pelos procedimentos menos complexos, como os enxertos de pele. Conclusão: este estudo trouxe um caso raro, ocorrido no centro-oeste brasileiro sem descrição semelhante prévia, apresentando dificuldades extremas de manejo clínico e cirúrgico que foram resolvidas mediante aprimoramento de técnicas terapêuticas pertinentes.
Caracterização de pacientes conforme score CHADSVASC2 em uma clínica de anticoaculação em Minas Gerais
Authors: Passaglia Bolina Helena , Corrêa Batista Hugo , De Faria Martins Braga Lucas , César Ribeiro da Silva Augusto , De Alencastro Curado Filipi , Moreira da Costa Josiane
Published: September 2023

Introdução: a varfarina é um anticoagulante oral (ACO) indicado para prevenção e tratamento de eventos tromboembólicos. Suas indicações incluem principalmente: fibrilação atrial, próteses cardíacas e tromboembolismo venoso. O score CHADSVASC2 que auxilia na estratificação de risco tromboembólico e indicação da anticoagulação oral podendo ser empregado na prática clínica. O presente trabalho se propôs a caracterizar pacientes com controle inadequado da anticoagulação oral em uma clínica de anticoagulação (CA), conforme o CHADSVASC2. Metodologia: trata-se de um estudo transversal. Foram incluídos pacientes com idade ≥18 anos, com indicação para anticoagulação crônica, uso de varfarina acima de 6 meses e qualidade da anticoagulação oral, mensurada pelo Therapeutic Time Range (TTR). Os pacientes foram captados em uma CA de um hospital de ensino de Minas Gerais, sendo analisados os prontuários de todos pacientes atendidos entre julho e dezembro de 2017. Pacientes com TTR <60% foram considerados com controleinadequado. Para cada paciente, calculou-se o risco de ocorrência de evento tromboembólico por meio do escore CHADSVASC2 que considera as seguintes variáveis: idade (<65 anos – 0 ponto (pt); 65-74 anos – 1pt; >75 anos – 2pt), sexo feminino (1pt), insuficiência cardíaca (IC) (1pt), hipertensão arterial (1pt), acidente vascular encefálico (AVE) /tromboembolismo (2pt), doença vascular (1pt) e diabetes mellitus (DM) (1pt). Os pacientes foram classificados como tendo risco baixo (0pt), moderado (1pt) ou alto (>2pt). Resultados: 393 pacientes foram incluídos no estudo, sendo a média de idade de 63,3 anos. identificou-se considerável percentual de pacientes com CHADSVASC2 ≥2 (351;89,3%), o que confirma a necessidade do paciente em usar anticoagulante adequadamente para prevenção de novos eventos tromboembólicos. Conclusão: ressalta-se a importância da realização de estudos descritivos envolvendo essapopulação para auxiliar na compreensão da farmacoterapia e definir estratégias que contribuam para o cuidado adequado do paciente.
Eficácia terapêutica do exenatide no tratamento da doença de Parkinson
Authors: Alcântara André Luiz de Lima Nascimento , Cardoso André Luiz Felipe Bezerra , Pereira Murilo Isidoro Pinheiro , Aquino Daniela  Sant’ Ana de , Mayer Andreia Biolchi
Published: September 2023

Introdução: a Doença de Parkinson é uma das doenças neurodegenerativas mais diagnosticadas no mundo sendo caracterizada como uma condição progressiva do Sistema Nervoso Central. A deficiência de dopamina é causada pela morte de neurônios dopaminérgicos da via nigro-estriatal, responsável pelo controle motor. Um novo composto denominado exenatide, análogo ao hormônio peptídico glucagon 1 (GLP-1), apresentou reações benéficas para o tratamento da Doença de Parkinson por meio de ensaios clínicos randomizados. Objetivo: realizar uma análise sistemática da literatura de estudos randomizados e seus respectivos ensaios clínicos sobre ações farmacoterapêuticas do composto exenatide para apontar os efeitos dos tratamentos proporcionados aos pacientes. Metodologia: foram realizadas pesquisas nas bases de dados PubMed, MEDLINE, ProQuest, Cochrane e Google Scholar, no período de agosto de 2022 a setembro de 2022 de estudos publicados entre os anos de 2013 a 2022, nos idiomas inglês, português e espanhol. Resultados: um total de 1.521 artigos foram encontrados, sendo que 4 estudos foram utilizadospara a análise. Os resultados demonstraram que todos os pacientes participantes dos grupos tratados com o composto exenatide apresentaram uma melhora nas avaliações das funções motoras em comparação aos grupos controles. A quantificação de proteínas específicas envolvidas na sinalização e atividade da insulina cerebral apresentaram maior quantidade de biomarcadores importantes para a cascata de sinalização de insulina em comparação com participantes usando placebo. Conclusão: evidencia-se a importância da realização de estudos mais aprofundados com o objetivo de verificar o grau de eficácia do composto na melhora do comportamento motor e consequentemente na neuroproteção.
Comprehensive assessment reveals numerous clinical and neurophysiological differences between MECP2‐allelic disorders
Authors: Pehlivan Davut , Huang Chengjun , Harris Holly K. , Coquery Christine , Mahat Aditya , Maletic‐Savatic Mirjana , Mignon Laurence , Aras Sukru , Glaze Daniel G. , Layne Charles S. , Sahelijo Leonardo , Zoghbi Huda Y. , McGinley Matthew J. , Suter Bernhard
Published: January 2025

Objective

Rett syndrome (RTT) and MECP2 duplication syndrome (MDS) result from under‐ and overexpression of MECP2, respectively. Preclinical studies using genetic‐based treatment showed robust phenotype recovery for both MDS and RTT. However, there is a risk of converting MDS to RTT, or vice versa, if accurate MeCP2 levels are not achieved. The aim of this study was to identify biomarkers distinguishing RTT from MDS.

Materials and Methods

We prospectively enrolled 11 MDS and 6 male RTT like (MRL) individuals for a panel of clinical and neurophysiological assessments over two visits, 8–10 months apart.

Results

We identified numerous clinical and physiological features as promising biomarkers. MRL individuals exhibited large amplitude whole body tremor, midline stereotypies (vs. hand flapping at sides in MDS), earlier neuromotor regression, and earlier onset but less commonly refractory epilepsy. In the neurophysiological domain, we observed several marked differences in sleep physiology between MDS/MRL and typically developing (TD) individuals including reduced sleeping time, increased delta power during rapid eye movement (REM) sleep, decreased occipital alpha and increased brain‐wide delta power during wakefulness, and reduced spindle density and duration. MRL individuals also had much lower delta power during NREM 2 and 3 stages than the TD group. We found differences in spindle duration in the temporal lobes and spindle amplitude in the frontal lobes between MDS and MRL.

Discussion

Our study revealed distinct clinical features of MDS and MRL that can be monitored during a clinical trial and may serve as target engagement, disease progression, or safety biomarkers for interventional studies.
Weaving Bonds: Constructing a Model to Unveil the Role of Relationship Memories in Satisfaction
Authors: Koc‐Arik Gizem , Ozdes Aylin
Published: January 2025

Relationship satisfaction is closely tied to various characteristics of recollected past events within romantic relationships. However, our understanding of how distinct characteristics of these memories, individually and collectively are related to satisfaction remains limited. This study aimed to explore the associations between these characteristics and examine their role in relationship satisfaction. Participants recalled two memories from their relationships and rated the memory characteristics. The results revealed relationships between event characteristics and both rehearsal and recollection. Yet, rehearsal did not mediate the relationship between event characteristics and recollection. When relationship satisfaction was incorporated into the model, negative events marked by high emotion and personal significance, were related to increased rehearsal frequency, which in turn was associated with lower relationship satisfaction. However, personally significant negative events also enhanced recollective features, which heightened relationship satisfaction. These findings highlight the crucial role of relationship memories in relationship satisfaction, especially for the negative events.
The False Balance Effect: Exploring Partition Dependence as a Potential Explanation
Authors: Han Tianshuang , Snook Brent , Day Martin V.
Published: January 2025

False balance arises when opposing viewpoints about a scientific issue are portrayed as more evenly matched than what the empirical evidence demonstrates. We examined the extent to which partition dependence is the psychological mechanism underlying the false balance effect. Participants (N = 360) read a statement about an interrogation practice (i.e., the use of false evidence ploys) that reached expert consensus, viewed data about the level of the expert consensus, and then assigned randomly to view (a) balanced expert comments in equal proportion on each side (3:3), (b) two‐sided comments with more consensus views (5:1), (c) two‐sided comments with more contrarian views (1:5), or (d) no comments at all. Results showed that balanced comments distorted perceived expert consensus and that two‐sided comments with more consensus views had the largest impact on debiasing perceived expert consensus. We discuss the implications of our findings for science communication efforts.
Hybrid Preceramic Aerogels for Oil and Solvent Cleanup
Authors: Icin Oyku , Vakifahmetoglu Cekdar
Published: January 2025

This study presents the first synthesis and characterization of monolithic hybrid preceramic aerogels using distinct drying techniques: ambient pressure (ambigels) and CO2 supercritical drying. Polymeric ambi/aerogels, derived from polyhydromethlysiloxane (PHMS) and divinylbenzene (DVB), are processed at 200 °C, while hybrid ceramic‐polymer (ceramer) is produced through pyrolysis at 600 °C. Despite variations in drying methods, polymer and ceramer ambi/aerogels exhibit comparable microstructural characteristics, bulk density, pore size and volume, and specific surface area (542–841 m2 g−1). Polymeric and ceramer ambigel with 90 vol% total porosity yield a compressive strength, reaching 2.5 MPa, demonstrating a low thermal conductivity of 0.046 W m−1 K−1. Sorption tests are conducted using oil and organic solvents in aqueous media to benefit their high hydrophobicity (112° < θ < 142°). Aerogels exhibit high sorption capacities: 13.17 g g−1 for sesame oil, 11.74 g g−1 for toluene, and 9.19 g g−1 for n‐hexane. The sorption rate for the oil is nearly 10 times slower than that for toluene and n‐hexane. Regarding regeneration and reusability, polymer and ceramer aerogels show consistent sorption properties cycles tested for n‐hexane and toluene.
Multidirectional Reorientation in the Ferroelastic van der Waals Semimetal Molybdenum Ditelluride
Authors: Kim Hyeon‐Sik , Koh Woochan , Kwon Gihyeon , Jeong Kwangsik , Jang Myeongjin , Lee Han Joo , Park Hyunjun , Kim Kwanpyo , Jeong Jaehun , Im Seongil , Cho Mann‐Ho
Published: January 2025

Ferroelastic properties in two‐dimensional materials have garnered significant attention due to their potential to control structural anisotropy, thereby influencing optical and electrical characteristics under external stress. Despite these potential applications, there remains a scarcity of reports on ferroelastic behavior in two‐dimensional van der Waals materials. In this study, we investigate multidirectional ferroelastic reorientation in the two‐dimensional van der Waals semimetallic phase of Molybdenum ditelluride (1T′ MoTe2). Employing a polymer encapsulation method, ferroelastic switching in 1T′ MoTe2 is examined via real‐time polarized optical imaging under uniaxial strain. Polarized Raman spectroscopy confirms the orientation of Mo–Mo chains in original and reoriented domains, revealing 120° rotational switching in reconstructed domains. Analysis using selective area electron diffraction and scanning transmission electron microscopy elucidate the atomic arrangements of original and reconstructed domains, including domain wall structures. Additionally, it is demonstrated that external uniaxial strain can differentiate between the stabilities of three equivalent states in 1T′ MoTe2, enabling manipulation of the orientation of Mo–Mo chains based on the direction of the applied strain. The findings highlight the capability for multidirectional ferroelastic reorientation in the two‐dimensional semimetal MoTe2 through the application of uniaxial strain.
High‐Purity Photoactive α‐Phase for Flexible Perovskite Photodetectors with Modified Electron Transport Layer
Authors: Hu Ying , Zhang Xinyu , Mo Xiaoliang , Chu Junhao , Fang Xiaosheng , Li Ziqing
Published: January 2025

Regulating the crystallization process of organic–inorganic halide perovskite is essential for the fabrication of reproducible and efficient optoelectronic devices. Herein, a vacuum‐assisted heating treatment strategy for precursor is developed to obtain a high‐purity photoactive phase perovskite. By eliminating residual H2O molecules from raw materials and solvents, the method prevents the Pb–I framework of perovskite from being destroyed. Additionally, the pre‐treated precursor possesses high‐valence iodoplumbate species leading to preferable crystallization for perovskite films. Furthermore, a high on‐off ratio of 1103 is attained under 0 V and 550 nm illumination by employing a vertical n–i–p photodetector based on pure 𝛼‐phase perovskite films and interface passivation carried out by incorporating phenethylammonium hydroiodide (PEAI) in the n‐type electron transport layer. The photodetector exhibits high sensitivity with the peak responsivity of 0.93 A W−1 and the detectivity of 1.55 × 1012 Jones in the visible light range, making it a potential candidate for an imaging application. The flexible photodetector fabricated on polyethylene terephthalate (PET) substrate maintains 98.6% photocurrent density after 300 times of bending and preliminarily realizes imaging sensing. The heat‐treating strategy improves the adaptability of perovskite to complex environments and enables the preparation of reproducible pure 𝛼‐phase perovskite films, which boast enormous potential for optoelectronic applications.
Wearable Pressure Sensor Based on Triboelectric Nanogenerator for Information Encoding, Gesture Recognition, and Wireless Real‐Time Robot Control
Authors: Guo Mengjia , Xia Yifan , Liu Jiaxuan , Zhang Yinghao , Li Min , Wang Xin
Published: January 2025

Wearable sensor has attracted a broad interesting in application prospect of human‐machine interaction (HMI). However, most of sensors are assembled in the shape of gloves to accurately capture complex hand motion information, thereby seriously blocking the hand to complete complex tasks. Herein, a wearable pressure sensor based on drum‐structured triboelectric nanogenerator (DS‐TENG) is developed to capture subtle pressure signals for physiological signal detection, information encoding, gesture recognition, and wireless real‐time robot control. The DS‐TENG enables a limit of detection down to 3.9 Pa pressure, which can sensitively capture human micromotion signals of pulse, throat sounds, and wrist muscles contraction. Especially, combined with a microprocessor and Morse code, the DS‐TENG worn on wrist can detect single‐finger motion signals to translate into regular voltage signals, which is employed to encode information of 26 letters and subsequently decode into the corresponding letters. Furthermore, with an aid of machine learning, the DS‐TENG array (2 × 2) can successfully achieve gesture recognition with high accuracy of 92% to wirelessly perform real‐time robot control. Consequently, the wearable pressure sensor based on DS‐TENG can capture subtle pressure signals for information encoding and wireless real‐time robot control, which demonstrates extreme potential in the field of HMI and artificial intelligence.
Rigid Fluorescent Indacenetetraone‐Based Semiconducting Polymers via Knoevenagel Condensation
Authors: Kang So‐Huei , Ghamari Pegah , Ruchlin Cory , Che Yuxuan , He Zhechang , Chan Quentin , Rosei Federico , Perepichka Dmytro F.
Published: January 2025

The synthesis of new donor‐acceptor polymers is reported through Knoevenagel condensation of indacenetetraone with aromatic dialdehydes. The obtained polymers possess exceptionally rigid planar backbones with a rotational barrier (for single C─C bonds) of 16–20 kcal mol−1, the highest among known conjugated polymers. These structural features confer several unusual properties, including remarkably narrow absorption bands with very high absorption coefficient (up to ≈3×105 cm−1) and efficient fluorescence in the red to near‐IR region (λmax 694–850 nm, quantum yield 10–29%). Systematic spectroscopic, electrical, and microstructural characterization supported by Density Functional Theory (DFT) calculations reveals the effects of heteroatoms and the conjugation lengths on the optoelectronic properties of these materials. The polymers exhibit ambipolar charge transport in field‐effect transistors, which can be tailored to show unipolar p‐type (0.1 cm2 V−1 s−1) and n‐type (0.05 cm2 V−1 s−1) behavior by adjusting the energy levels at the polymer/metal contacts. Additionally, their application is demonstrated as acceptors in all‐polymer organic photovoltaic devices with commercial donor polymers, achieving a power conversion efficiency (PCE) of 11%.
Navigating Tumor Microenvironment Barriers with Nanotherapeutic Strategies for Targeting Metastasis
Authors: Thomas Mahima Rachel , Badekila Anjana Kaveri , Pai Vishruta , S Nijil , Bhandary Yashodhar , Rai Ankit , Kini Sudarshan
Published: January 2025

Therapeutic strategy for efficiently targeting cancer cells needs an in‐depth understanding of the cellular and molecular interplay in the tumor microenvironment (TME). TME comprises heterogeneous cells clustered together to translate tumor initiation, migration, and proliferation. The TME mainly comprises proliferating tumor cells, stromal cells, blood vessels, lymphatic vessels, cancer‐associated fibroblasts (CAFs), extracellular matrix (ECM), and cancer stem cells (CSC). The heterogeneity and genetic evolution of metastatic tumors can substantially impact the clinical effectiveness of therapeutic agents. Therefore, the therapeutic strategy shall target TME of all metastatic stages. Since the advent of nanotechnology, smart drug delivery strategies are employed to deliver effective drug formulations directly into tumors, ensuring controlled and sustained therapeutic efficacy. The state‐of‐the‐art nano‐drug delivery systems are shown to have innocuous modes of action in targeting the metastatic players of TME. Therefore, this review provides insight into the mechanism of cancer metastasis involving invasion, intravasation, systemic transport of circulating tumor cells (CTCs), extravasation, metastatic colonization, and angiogenesis. Further, the novel perspectives associated with current nanotherapeutic strategies are highlighted on different stages of metastasis.
Sargassum Nanocellulose‐Based Fully Ingestible Supercapacitor
Authors: He Qian , Ling Zhang‐Chi , Li De‐Han , Yang Kun‐Peng , Yang Huai‐Bin , Yan Zheng‐Kun , Han Zi‐Meng , Zhao Yu‐Xiang , Yin Chong‐Han , Guan Qing‐Fang , Yu Shu‐Hong
Published: January 2025

Small high‐performance energy modules have significant practical value in the biomedical field, such as painless diagnosis, alleviation of gastrointestinal discomfort, and electrical stimulation therapy. However, due to performance limitations and safety concerns, it is a formidable challenge to design a small, emerging ingestible power supply. Here, a fully ingestible supercapacitor (FISC) constructed of sargassum cellulose nanofiber is presented. FISCs exhibit an electrode areal capacitance of 2.29 F cm−2 and a high energy density of 307 µWh cm−2. Furthermore, over 90% of the antibacterial activity against Escherichia coli is achieved during the self‐discharge process. Therefore, following insertion into an enteric capsule, this device can enable a disposable power supply and electrostimulation for bacteriostasis in the intestine after being swallowed by a human, which offers new possibilities for scientific and simple therapy.
Co(III)‐Catalyzed Regioselective C−H Dienylation of Indolines and Indoles with Allenyl Carbinol Acetates
Authors: Shukla Rahul K. , Singh Anurag , Shetty Rakesh , Volla Chandra M. R.
Published: January 2025

Herein, we present a Co(III)‐catalyzed regioselective C7‐H dienylation of indolines at room temperature employing allenyl carbinol acetate as an efficient dienylating reagent. The reaction proceeds via C−H activation, regioselective 2,1‐migratory insertion of the allene followed by β‐acetate elimination, resulting in a diverse array of C7‐dienylated indolines. The methodology was further extended to C2‐H dienylation of indoles, affording either branched or linear dienes, contingent on the nature of the substituent present at the allenylic carbon. In addition, hydroarylation of allenes was also successfully achieved with tri‐substituted allenes, which was elusive so far under cobalt catalysis.
Scalable Electrochemical Dehalogenative Carboxylation without a Sacrificial Metal Anode
Authors: Petrovic Nikola , Laudadio Gabriele , Salazar Chase A. , Kong Caleb J. , Verghese Jenson , Hesketh Alexander , Reyes Giselle P. , Desrosiers Jean‐Nicolas , Oliver Kappe C. , Cantillo David
Published: January 2025

A scalable electrochemical procedure for the synthesis of carboxylic acids from organic halides has been developed using a spinning cylinder electrode electrochemical reactor. The electrochemical process is based on the reductive dehalogenation of the starting material followed by trapping of the resulting carbanion with CO2. The protocol is compatible both with organic chlorides and bromides and uses inexpensive graphite and stainless steel as electrode materials. As sacrificial metal anodes are avoided, the method can be readily scaled up in flow mode. The procedure is compatible with a wide range of substrates (24 examples), including aryl and alkyl halides as well as heterocyclic compounds. Multigram scale preparations in flow mode have been demonstrated by processing 600 mL of reaction mixture in an electrolyte recirculation setup.
The Metabolite Indole‐3‐Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation
Authors: Liu Wu , Wang Jingyu , Yang Heng , Li Congcong , Lan Wanqi , Chen Tingtao , Tang Yanhua
Published: January 2025

Emerging research has highlighted the significant role of the gut microbiota in atherosclerosis (AS), with microbiota‐targeted interventions offering promising therapeutic potential. A central component of this process is gut‐derived metabolites, which play a crucial role in mediating the distal functioning of the microbiota. In this study, a comprehensive microbiome‐metabolite analysis using fecal and serum samples from patients with atherosclerotic cardiovascular disease and volunteers with risk factors for coronary heart disease and culture histology is performed, and identified the core strain Bacteroides ovatus (B. ovatus). Fecal microbiota transplantation experiments further demonstrated that the gut microbiota significantly influences AS progression, with B. ovatus alone exerting effects comparable to volunteer feces from volunteers. Notably, B. ovatus alleviated AS primarily by restoring the intestinal barrier and enhancing bile acid metabolism, particularly through the production of indole‐3‐acetic acid (IAA), a tryptophan‐derived metabolite. IAA inhibited the TLR4/MyD88/NF‐κB pathway in M1 macrophages, promoted M2 macrophage polarisation, and restored the M1/M2 polarisation balance, ultimately reducing aortic inflammation. These findings clarify the mechanistic interplay between the gut microbiota and AS, providing the first evidence that B. ovatus, a second‐generation probiotic, can improve bile acid metabolism and reduce inflammation, offering a theoretical foundation for future AS therapeutic applications involving this strain.
Phonon Involved Photoluminescence of Mn2+ Ions Doped CsPbCl3 Micro‐Size Perovskite Assembled Crystals
Authors: Gao Jialiang , Guo Yangyang , Zhang Xiuhai , Liu Lu , Li Huixin , Cheng Zeyi , Liu Peng , Dong Fan , Wu Jiandong , Liu Taihong , Sun Huaming , Zhang Miao , Aubin Hervé , Wang Hongyue , Wang Hongqiang
Published: January 2025

Mn2+ ions doped CsPbCl3 perovskite nanocrystals (NCs) exhibit superiority of spin‐associated optical and electrical properties. However, precisely controlling the doping concentration, doping location, and the mono‐distribution of Mn2+ ions in the large‐micro‐size CsPbCl3 perovskite host is a formidable challenge. Here, the micro size CsPbCl3 perovskite crystals (MCs) are reported with uniform Mn2+ ions doping by self‐assembly of Mn2+ ions doped CsPbCl3 perovskite NCs. The electron–phonon coupling strength is enhanced in the perovskite self‐assembled CsPbCl3 MCs, which remarkably accelerates the PL decay of Mn2+ ions in room temperature. Furthermore, the phonon‐involved PL emission splits to two peaks at low temperature of 80 K, due to the phonon emission and absorption‐induced energy exchange for exciton recombination in Mn2+ ions. These findings not only demonstrate a novel material system but also introduce a new theoretical framework for phonon‐modulated PL manipulation in Mn2+‐doped perovskite materials.
Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression
Authors: Wang Jing , Yu Weiqiang , Shen Hui , Sang Yanxiang , Zhang Hongjie , Zheng Benyan , Peng Xue , Hu Yuan , Ma Xiaopeng , Yang Zhenye , Yu Fazhi
Published: January 2025

Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol‐functionalized BP (BP‐PEG) nanosheets in breast cancer models. Using immunocompetent mouse models‐including 4T1 orthotopic BALB/c mice and MMTV‐PyMT transgenic mice, it is found that BP‐PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells. Mass cytometry analysis reveals that BP‐PEG reshapes the tumor immune microenvironment by recruiting neutrophils. Neutrophil depletion experiments further demonstrate that the antitumor effects of BP‐PEG are dependent on neutrophils. Moreover, bulk and single‐cell RNA sequencing indicate that BP‐PEG is mainly taken up by macrophages, leading to the release of inflammatory factors such as IL1A and CXCL2, which enhance neutrophil recruitment and activation, thereby amplifying the antitumor immune response. Finally, co‐culture assays confirm that BP‐PEG indeed enhances the antitumor activity of neutrophils and natural killer (NK) cells. These findings position BP‐PEG as an immunomodulatory agent capable of reprogramming the tumor microenvironment to promote innate immunity against breast cancer. By stimulating neutrophil‐mediated antitumor activity, BP‐PEG offers a unique therapeutic approach that can potentially enhance the efficacy of existing cancer immunotherapies.