bluuebunny/crossref_metadata_2025 huggingface dataset:
A propensity score matching study: The prevalence of mental health problems among pregnant women at first antenatal care increased in Chongqing during the first wave of the COVID-19 pandemic
Authors: Guo Jiamei , Li Xiao , He Jinglan , Ai Ming , Gan Yao , Zhang Qi , Zheng Anhai , Chen Wanjun , Chen Lulu , Liang Sisi , Yu Xiaoyu , Kuang Li
Published: April 2023

Background

The 2019 coronavirus disease (COVID-19) pandemic increased the risks of mental health challenges, especially anxiety and depression. However, the impact of COVID-19 on mental health during pregnancy has not been fully established. Therefore, we investigated the impact of the COVID-19 pandemic on maternal mental health.

Methods

Two cohorts of pregnant women at their first antenatal care in the First Affiliated Hospital of Chongqing Medical University were enrolled in this study. One cohort was enrolled before the COVID-19 outbreak, from 1 June to 31 December 2019 (n = 5,728, pre-COVID-19 group), while the other was enrolled during the COVID-19 pandemic, from 24 January to 23 March 2020 (n = 739, COVID-19 pandemic group). Symptoms of depression, anxiety, and somatization disorders were assessed by the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-15 (PHQ-15), with a cutoff point of 10 for moderate-to-severe depression, anxiety, and somatoform symptoms. The propensity score matching method (1:1) was used to balance differences in demographic characteristics between groups. A chi-square analysis was performed to compare differences in demographic characteristics between the groups.

Results

Prevalence of moderate-to-severe depression, anxiety, and somatoform symptoms among pregnant women at their first antenatal care visit during the COVID-19 pandemic (9.5, 2.2, and 20.8%, respectively) was significantly lower than those before the pandemic (16.3, 4.4, and 25.7%, respectively) (p < 0.05). Compared with the same period before the pandemic, during the pandemic, the number of women newly registered for antenatal care decreased by nearly 50%. There were significant differences in the distributions of demographic characteristics between the groups (p < 0.05). After matching the demographic characteristics, differences in the prevalence of maternal mental health disorders between the groups reversed dramatically. Prevalence of moderate-to-severe depression, anxiety, and somatoform symptoms during the COVID-19 pandemic in this population (2.3, 9.6, and 20.8%, respectively) was significantly higher than those before the pandemic (0.3, 3.9, and 10%, respectively) (p < 0.05).

Conclusion

The COVID-19 pandemic increased mental health risks among pregnant women. As a large proportion of pregnant women with mental health challenges delay their prenatal care or change healthcare facilities after the outbreak of public health emergencies, there is a need to establish a balanced healthcare system in medical institutions at all levels.
Aggressive behavior in adolescent: The importance of biopsychosocial predictors among secondary school students
Authors: Fauzi Fatimah Ahmad , Zulkefli Nor Afiah Mohd , Baharom Anisah
Published: April 2023

Introduction

Overt aggression is a common type of aggression observed among adolescents, which is apparent and outward confrontational acts manifested physically and verbally, such as fighting and shouting. It has become a major public health concern, as it results in detrimental health impacts like injury, mental health, and social problems.

Methods

An observational study was conducted among 16-year-old school students to determine their biopsychosocial predictors, using stratified proportionate population sampling. Pre-tested surveys were distributed to measure students’ aggression, biological, psychological, and social factors.

Results

A total of 463 students from four public secondary schools participated in the study, with a median aggression score was 23.00 (IQR=12.00). The significant predictors of aggression from multivariate analysis were Malay race, frequent dessert intakes, attitude towards aggression, low family income, and peer deviant affiliation (F [8, 244] = 15.980, p < 0.001, adjusted R2 = 0.290).

Discussion

Adolescent aggression determinants are collectively impacted as a result of biological, psychological, and social predictors and need to be focused on in interventional strategies.
SkyWinder: A Python package for flight control, telemetry, and image analysis
Authors: Kjellstrand Carl Björn , Williams Bifford P.
Published: April 2023

SkyWinder is an open-source Python package useful for instrument control, telemetry, and image analysis. It is adapted from software that successfully managed flight control, telemetry, preliminary image analysis, and data visualization for a balloon-borne mission and it has broad uses for mid- and upper-atmosphere science instrumentation including aurora, cloud, and airglow imagers. SkyWinder will save future aeronomy experiments significant time and money, and lowers the barrier to entry in analyzing data hosted in public available repositories. Our software consists of two distinct parts: the flight and analysis modules. The SkyWinder flight package includes modular distributed flight control including telemetry and subsystem coordination for running mobile aeronomy experiments such as balloon-borne payloads, airplanes, sounding rockets, and suborbital reusable launch vehicles (sRLVs), as well as isolated semi-autonomous ground instruments. The SkyWinder analysis software provides functionality more broadly useful in neutral upper atmosphere dynamics, such as pointing reconstruction, image projection, preliminary image processing, and various image analysis techniques.
Using Energy Particle Detection Technology on the Tiangong’s Space Station’s Wentian Laboratory Cabin Module
Authors: Shen Guohong , Zhang Shenyi , Zhang Xianguo , Zhang Huanxin , Yuan Bin , Hou Donghui , Wang Chunqin , Quan Zida , Yang Zhe , Sun Yueqiang
Published: April 2023

To conduct real-time monitoring of the particle radiation environment in the orbit of the Tiangong space station, the installation of an energy particle detector operating on the outside of Wentian laboratory cabin module is proposed. Monitoring the energy, flux, and direction of high-energy protons, electrons, heavy ions, and neutrons in orbital space, as well as the LET spectrum and radiation dose rate generated by them, provides an important basis for studying the mechanism of the space environment that causes harm to space stations and astronauts. It also provides the necessary space environment parameters for the scientific experiment instruments on the space station. During its ground development process, the detector was verified by various calibration methods such as standard radioactive sources, equivalent signal generators, and particle accelerators. The results show that the detector can realize discrimination of particle ingredients (electrons, protons, heavy ions, and neutrons). Meanwhile, the measurement indexes can also realize target requirements, namely, from lower limit of 20 keV for medium-energy electrons and protons to heavy ion GeV, 0.025 eV~100 MeV for neutrons, and 0.233~17,475 keV/μm for the LET spectrum and 0.1~1000 mGy/day for the dose rate produced. The measurement precisions of all indexes are better than approximately 16%.
Sustainability Evaluation of Pastoral Livestock Systems
Authors: Ouali Mohamed , Belhouadjeb Fathi Abdellatif , Soufan Walid , Rihan Hail Z.
Published: April 2023

In order to manage important transformations affecting a steppe area, it is necessary to analyze the existing pastoral system by evaluating the sustainability of its subsystems of production. For this reason, in this study, a tool for the evaluation of the sustainability of livestock production in the steppe area was used in order to identify the most sustainable systems. The study was conducted using a survey of 87 livestock farmers (production units) in the region ranked first in terms of sheep production. Principal component analysis (PCA) enabled us to identify two production systems: (i) the pastoral production system, characterized by the mobility of livestock and its high dependence on concentrated feed; (ii) the agropastoral system, combining fodder and livestock production, which is sedentary and semi-extensive. Using a grid for evaluating the sustainability of livestock systems in steppe regions, the impact of each system on the environment (environmental, economic, and social) was examined, and the results showed that the feed system was unbalanced, with high pressure on steppe rangelands. Nevertheless, multiple ways of improving these systems emerged from the analysis, such as encouraging the production of fodder and its association with livestock, on new spatial, temporal, regional, and national levels.
Functions of Snake Sloughs in Bird Nests Vary with Habitats: A Test of the Anti-Predation Hypothesis
Authors: Liu Jinmei , Ma Laikun , Jin Yameng , Zhang Fangfang , Li Xintong , Liang Wei
Published: April 2023

Snake sloughs in bird nests can reduce nest predation and serve as an anti-predator strategy. However, the anti-predator function of snake sloughs in nests has only been tested twice, and it is difficult to speculate around the origin of the differences, which may well include habitat, as predator species and predation risk vary in different habitat types. Habitat would be a good place to speculate as to how differences in habitats could explain differences in responses by nest predators. Thus, we selected three different habitats, namely, the Diaoluoshan National Nature Reserve in Hainan (DLS, tropical forest), the Hainan Normal University campus (HNU, urban area), and Qingchuifeng National Forest Park in Hebei (QCF, suburban area), to verify the anti-predator function of snake sloughs in bird nests. The experimental results showed that snake sloughs in the nests reduced the predation rate of the experimental nests in HNU, whereas no such effect occurred in DLS and QCF. This suggests that the anti-predatory function of snake sloughs may not be the same over some environmental gradients and could be dependent on the species of nest predators and food resources in the habitat, which does not apply to all types of habitats.
Identification of Ruminal Fermentation Curves of Some Legume Forages Using Particle Swarm Optimization
Authors: Palangi Valiollah
Published: April 2023

The modeling process has a wide range of applications in animal nutrition. The purpose of this work is to determine whether particle swarm optimization (PSO) could be used to explain the fermentation curves of some legume forages. The model suited the fermentation data with minor statistical differences (R2 > 0.98). In addition, reducing the number of iterations enhanced this method’s benefits. Only Models I and II could successfully fit the fermentability data (R2 > 0.98) in the vetch and white clover fermentation curve because the negative parameters (calculated in Models III and IV) were not biologically acceptable. Model IV could only fit the alfalfa fermentation curve, which had higher R values and demonstrated the model’s dependability. In conclusion, it is advised to use PSO to match the fermentation curves. By examining the fermentation curves of feed materials, animal nutritionists can obtain a broader view of what ruminants require in terms of nutrition.
Red Sea Bream Iridovirus Kinetics, Tissue Tropism, and Interspecies Horizontal Transmission in Flathead Grey Mullets (Mugil cephalus)
Authors: Kim Kyung-Ho , Kang Gyoungsik , Woo Won-Sik , Sohn Min-Young , Son Ha-Jeong , Kwon Mun-Gyeong , Kim Jae-Ok , Park Chan-Il
Published: April 2023

Red sea bream iridovirus (RSIV) causes significant economic losses in the aquaculture industry. We analyzed the pathogenicity of RSIV in flathead grey mullets (Mugil cephalus), the correlation of histopathological lesions, and interspecies horizontal transmission, through immersion infection and cohabitation challenges. Flathead grey mullets, which were challenged by immersion infection, exhibited mortality at 14 and 24 days after RSIV exposure. Viral shedding in seawater peaked 2–3 days before or after the observed mortality. Specific lesions of RSIV were observed in the spleen and kidney, and the correlation between histopathological grade and viral load was the highest in the spleen. In a cohabitation challenge, flathead grey mullets were the donors, and healthy rock bream, red sea bream, and flathead grey mullets were the recipients. Viral shedding in seawater was the highest in flathead grey mullet and rock bream at 25 °C, with 106.0 RSIV copies L/g at 14 dpi. No mortality was observed in any group challenged at 15 °C, and no RSIV was detected in seawater after 30 dpi. The virus shed from RSIV-infected flathead grey mullets caused horizontal transmission through seawater. These findings suggest that rapid decision-making is warranted when managing disease in fish farms.
Immunogenicity and Efficacy of a Feed-Based Bivalent Vaccine against Streptococcosis and Motile Aeromonad Septicemia in Red Hybrid Tilapia (Oreochromis sp.)
Authors: Mohd Ali Nur Shidaa , Saad Mohd Zamri , Azmai Mohammad Noor Amal , Salleh Annas , Zulperi Zarirah Mohamed , Manchanayake Tilusha , Zahaludin Muhammad Amir Danial , Basri Lukman , Mohamad Aslah , Md Yasin Ina Salwany
Published: April 2023

Streptococcosis and motile Aeromonad septicemia (MAS) are the main bacterial diseases in tilapia culture worldwide, causing significant economic losses. Vaccination is an effective method of preventing diseases and contributes to economic sustainability. This study investigated the immuno-protective efficacy of a newly developed feed-based bivalent vaccine against streptococcosis and MAS in red hybrid tilapia. The feed-based bivalent vaccine pellet was developed by incorporating the formalin-killed S. agalactiae and A. hydrophila antigens into a commercial feed pellet with palm oil as the adjuvant. The bivalent vaccine was subjected to feed quality analyses. For immunological analyses, 900 fish (12.94 ± 0.46 g) were divided into two treatment groups in triplicate. Fish in Group 1 were unvaccinated (control), while those in Group 2 were vaccinated with the bivalent vaccine. The bivalent vaccine was delivered orally at 5% of the fish’s body weight for three consecutive days on week 0, followed by boosters on weeks 2 and 6. Lysozyme and enzyme-linked immunosorbent assays (ELISAs) on serum, gut lavage, and skin mucus were performed every week for 16 weeks. Lysozyme activity in vaccinated fish was significantly (p ≤ 0.05) higher than in unvaccinated fish following vaccination. Similarly, the IgM antibody levels of vaccinated fish were significantly (p ≤ 0.05) higher after vaccination. The bivalent vaccine provided high protective efficacy against S. agalactiae (80.00 ± 10.00%) and A. hydrophila (90.00 ± 10.00%) and partial cross-protective efficacy against S. iniae (63.33 ± 5.77%) and A. veronii (60.00 ± 10.00%). During the challenge test, fewer clinical and gross lesions were observed in vaccinated fish compared with unvaccinated fish. Histopathological assessment showed less severe pathological changes in selected organs than the unvaccinated fish. This study showed that vaccination with a feed-based bivalent vaccine improves immunological responses in red hybrid tilapia, and thus protects against streptococcosis and MAS.
The Thermal Effect of Various Local Park Settings: A Simulation-Based Case Study of Sunshine Coast, Australia
Authors: Abuseif Majed
Published: April 2023

Local parks are widely used to mitigate urban heat islands. However, the increase of dry weather periods in subtropical climates has caused natural grass failure, leading some city councils to replace it with artificial grass. Therefore, this study investigates various local park settings to assess the performance of different ground covers (i.e., irrigated and non-irrigated natural grass, bare soil, and artificial grass) and the influence that tree proximity has on them, as well as the total thermal performance of the investigated local parks. This study finds that non-irrigated parks could harm park users’ health due to the high concentration of mean radiant temperature (MRT) around trees. Although the surface temperature of the artificial grass was higher (2.60 °C) than that of asphalt during periods of peak temperature, the parks using artificial grass performed better at reducing air temperature and enhancing thermal comfort than the ones with dry grass or bare soil, where both tree proximity and soil water content played significant roles. However, artificial grass negatively affected night cooling, resulting in a poorer daily performance. This study discusses the influence of various park settings on air temperature, MRT, thermal comfort, surface temperature, soil temperature, and water content. In addition, various recommendations and settings are offered to direct decision makers and future studies.
Determining the Geogenic Radon Potential in Different Layouts and Numbers of Points
Authors: Lupulescu Alexandru , Baciu Călin , Dicu Tiberius , Burghele Bety-Denissa , Cucoș Alexandra Laura
Published: April 2023

The geogenic radon potential is primarily controlled by the geological characteristics of the site, such as the rock type and structural elements, as well as the permeability of the soil. Depending on the scope of the survey, the geogenic radon potential can be mapped based on measurements conducted in the field at various resolutions. Detailed surveys are generally labour-intensive and time-consuming. Therefore, a balance should be reached between the desired level of precision and the required amount of effort, delivering the best results with the least number of resources. The international literature describes a variety of surveying techniques. This study was undertaken in a region of the central zone of the Poiana Rusca Mountains (Southern Carpathians, Romania) that contains several metamorphic, volcanic, and sedimentary rock types. The primary objective of the study is to compare alternative sampling point configurations, which vary in number and arrangement. The objective was to achieve the most accurate representation of the calculated geogenic radon potential while limiting the number of measurements and the time and effort associated with them. Radon activity concentration and soil permeability data were collected from 34 locations using seven alternative layouts of the sampling points. The proposed layouts were based on various configurations of fifteen, nine, five, and three sampling points. Locally, in some of the metamorphic units and in the regions containing sedimentary deposits with volcanic intercalations, the geogenic radon potential was found to be elevated. The results indicate that the three-measuring-point configuration is acceptable for general geogenic radon potential surveys.
Study on the Hemispheric Asymmetry of Thermospheric Density Based on In-Situ Measurements from APOD Satellite
Authors: Ai Jiangzhao , Li Yongping , Zhang Xianguo , Xiao Chao , Chen Guangming , Zheng Xiaoliang , Zhang Zhiliang
Published: April 2023

In this article, high spatiotemporal resolution data obtained by the atmospheric density detector carried by China’s APOD satellite are used to study the hemispheric asymmetry of thermospheric density. A detailed analysis is first performed on the dual magnetic storm event that occurred near the autumnal equinox on 8 September 2017. The results show that the enhancement ratio of atmospheric density in the southern polar region (SPR) on the duskside was approximately 1.33–1.65 times that of the northern polar region (NPR), demonstrating a strong hemispheric asymmetry of thermospheric atmospheric density response during the magnetic storm. However, the asymmetry response was smaller on the dawnside, suggesting that the hemispheric density response asymmetry is related to local time (LT). The energy injection in high-latitude regions increases local atmospheric density and forms traveling atmospheric disturbances (TADs). TADs can propagate to low-latitude regions over several hours and affect the global distribution of thermospheric atmospheric density. Similarly, the geomagnetic index fitting slope of SPR relative density difference is greater than that of NPR. The SuperDARN convection pattern indicates that the plasma convection velocity of SPR is significantly greater than that of NPR, indicating that joule heating caused by neutral friction of ions in the Southern Hemisphere may be stronger. Subsequently, an analysis of annual solar activity and seasons was carried out on the thermospheric NPR, SPR atmospheric density, and their differences from December 2015 to December 2020. The results show that thermospheric atmospheric density decreases overall as the number of sunspots decreases. The differences between the NPR and SPR atmospheric densities in the thermosphere exhibits a noticeable annual periodicity. The NPR and SPR atmospheric densities appear to have different distribution characteristics in different seasons. The NPR density peak is mainly in March or April. In particular, the “double-peak” phenomenon occurred in 2017, with peaks in March and September, while the most obvious feature of SPR atmospheric density is that its minimum value occurs in the summer months of June and July. This paper reveals the annual, seasonal, and magnetic storm response characteristics of the hemispheric asymmetry of thermospheric atmospheric density, which has significant implications for the study of multilayer energy coupling of the magnetosphere–ionosphere–thermosphere.
A Statistical Analysis of Tropical Cyclone-Induced Low-Level Winds near Taiwan Island
Authors: Xue Lin , Li Ying , Yao Sen
Published: April 2023

Using ERA5 reanalysis data and the tropical cyclone (TC) best track datasets from the China Meteorological Administration and Joint Typhoon Warning Center (from 1979 to 2021), TC-induced low-level winds near Taiwan Island are statistically analyzed. This study mainly concerns TC activity, low-level wind fields around Taiwan Island under TCs, and the detailed characteristics of TC wind structure. Results show that on average, 8.3 TCs enter the study region near Taiwan Island every year mainly from May to November, with more frequent and stronger TCs on the eastern and southern sides of Taiwan Island. For TC centers located at different positions around Taiwan Island, positive and negative vertical vorticity belts alternate between Taiwan Island and the TC center. Moreover, stronger and more frequent TC-induced winds mainly occur on the eastern side of Taiwan Island and the north of Taiwan Strait. TCs to the east of Taiwan Island have stronger maximum sustained wind than those on the western side of the island. Radii of the maximum wind (RMW) for TCs around Taiwan Island range from 5 to 90 nautical mile (nm, 9.3 to 116.7 km) with a mean value of 24.7 nm (44.4 km). Moreover, the RMWs of TCs are the largest (smallest) when the TC centers are located to the southwest (east) of the island. In addition, the outer sizes of TC winds vary from 52 to 360 nm (17.2 to 666.7 km) in the study region, with 187.4 nm (347.1 km) on average, and smaller values for TCs on the western side of the island. The average radii of severe winds, including R34, R50, and R64, are largest in the northeast quadrant and smallest in the southwest quadrant of the TC. The higher the specific wind speed is, the smaller the TC radius and the more symmetric its wind circle. These statistical results may provide references for TC gale forecasting and wind-resistant design for offshore engineering to mitigate TC-induced wind hazards.
Distance Measures Based on Metric Information Matrix for Atanassov’s Intuitionistic Fuzzy Sets
Authors: Ren Wenjuan , Yang Zhanpeng , Li Xipeng
Published: April 2023

The metric matrix theory is an important research object of metric measure geometry and it can be used to characterize the geometric structure of a set. For intuitionistic fuzzy sets (IFS), we defined metric information matrices (MIM) of IFS by using the metric matrix theory. We introduced the Gromov–Hausdorff metric to measure the distance between any two MIMs. We then constructed a kind of metric information matrix distance knowledge measure for IFS. The proposed distance measures have the ability to measure the distance between two incomplete intuitionistic fuzzy sets. In order to reduce the information confusion caused by the disorder of MIM, we defined a homogenous metric information matrix distance by rearranging MIM. Some theorems are given to show the properties of the constructed distance measures. At the end of the paper, some numerical experiments are given to show that the proposed distances can recognize different patterns represented by IFS.
Impact of Surface Structure on SEI for Carbon Materials in Alkali Ion Batteries: A Review
Authors: Zhao Xvtong , Chen Ying , Sun Hao , Yuan Tao , Gong Yinyan , Liu Xinjuan , Chen Taiqiang
Published: April 2023

Due to their low cost, suitable working potential and high stability, carbon materials have become an irreplaceable anode material for alkali ion batteries, such as lithium ion batteries, sodium ion batteries and potassium ion batteries. During the initial charge, electrolyte is reduced to form a solid electrolyte interphase (SEI) on the carbon anode surface, which is an electron insulator but a good ion conductor. Thus, a stable surface passivation is obtained, preventing the decomposition of electrolyte in the following cycles. It has been widely accepted that SEI is essential for the long-term performance of batteries, such as calendar life and cycle life. Additionally, the initial coulombic efficiency, rate capability as well as safety of the batteries are dramatically influenced by the SEI. Extensive research efforts have been made to develop advanced SEI on carbon materials via optimization of electrolytes, including solutes, solvents and additives, etc. However, SEI is produced via the catalytic decomposition of electrolyte by the surface of electrode materials. The surface structure of the carbon material is another important aspect that determines the structure and property of SEI, which little attention has been paid to in previous years. Hence, this review is dedicated to summarizing the impact of the surface structure of carbon materials on the composition, structure and electrochemical performance of the SEI in terms of surface atoms exposed, surface functionalization, specific surface area and pore structure. Some insights into the future development of SEI from the perspective of carbon surface are also offered.
Descriptor-Based Graded Electrode Microstructures Design Strategies of Lithium-Ion Batteries for Enhanced Rate Performance
Authors: Shan Qiang , Liu Yuwen , Chen Shengli
Published: April 2023

Microstructure engineering of electrodes is one of the efficient routes to improve rate performance of lithium-ion batteries (LIBs). Currently, there is a lack of descriptors to rationally guide the regional electrode design. Here, we propose two descriptors, the time differential of the average state of lithium (SoL) and the span of SoL in individual particles, to identify the rate performance constraints across the electrode depth. 3D microstructure-based electrochemical simulations are performed on a homogeneous electrode, and the predictability of the microstructure-based model is verified with the experimental measurement on a LiNi1/3Mn1/3Co1/3O2 electrode. At electrode level, the descriptors divide the electrode into four regions, namely, a solid-state transport (SST)-controlled region, two mixed SST and liquid-state transport (LST)-controlled regions (SST-dominant and LST-dominant, respectively), and an LST-controlled region. Based on these insights, dual-gradient electrodes are designed with smaller particles in the SST-controlled region and graded porosity increasing from current collector to the separator. Results show that the optimized dual-gradient electrode has significantly more excellent LST capability compared to the homogeneous electrode, thus improving the utilization of particles near the collector. As a result, the capacity performance of the optimized dual-gradient electrode increases by 39% at 5C without sacrificing the gravimetric energy density.
Response to Mechanical Properties and Physiological Challenges of Fascia: Diagnosis and Rehabilitative Therapeutic Intervention for Myofascial System Disorders
Authors: Kodama Yuya , Masuda Shin , Ohmori Toshinori , Kanamaru Akihiro , Tanaka Masato , Sakaguchi Tomoyoshi , Nakagawa Masami
Published: April 2023

Damage to the fascia can cause significant performance deficits in high-performance sports and recreational exercise and may contribute to the development of musculoskeletal disorders and persistent potential pain. The fascia is widely distributed from head to toe, encompassing muscles, bones, blood vessels, nerves, and internal organs and comprising various layers of different depths, indicating the complexity of its pathogenesis. It is a connective tissue composed of irregularly arranged collagen fibers, distinctly different from the regularly arranged collagen fibers found in tendons, ligaments, or periosteum, and mechanical changes in the fascia (stiffness or tension) can produce changes in its connective tissue that can cause pain. While these mechanical changes induce inflammation associated with mechanical loading, they are also affected by biochemical influences such as aging, sex hormones, and obesity. Therefore, this paper will review the current state of knowledge on the molecular level response to the mechanical properties of the fascia and its response to other physiological challenges, including mechanical changes, innervation, injury, and aging; imaging techniques available to study the fascial system; and therapeutic interventions targeting fascial tissue in sports medicine. This article aims to summarize contemporary views.
WBM-DLNets: Wrapper-Based Metaheuristic Deep Learning Networks Feature Optimization for Enhancing Brain Tumor Detection
Authors: Ali Muhammad Umair , Hussain Shaik Javeed , Zafar Amad , Bhutta Muhammad Raheel , Lee Seung Won
Published: April 2023

This study presents wrapper-based metaheuristic deep learning networks (WBM-DLNets) feature optimization algorithms for brain tumor diagnosis using magnetic resonance imaging. Herein, 16 pretrained deep learning networks are used to compute the features. Eight metaheuristic optimization algorithms, namely, the marine predator algorithm, atom search optimization algorithm (ASOA), Harris hawks optimization algorithm, butterfly optimization algorithm, whale optimization algorithm, grey wolf optimization algorithm (GWOA), bat algorithm, and firefly algorithm, are used to evaluate the classification performance using a support vector machine (SVM)-based cost function. A deep-learning network selection approach is applied to determine the best deep-learning network. Finally, all deep features of the best deep learning networks are concatenated to train the SVM model. The proposed WBM-DLNets approach is validated based on an available online dataset. The results reveal that the classification accuracy is significantly improved by utilizing the features selected using WBM-DLNets relative to those obtained using the full set of deep features. DenseNet-201-GWOA and EfficientNet-b0-ASOA yield the best results, with a classification accuracy of 95.7%. Additionally, the results of the WBM-DLNets approach are compared with those reported in the literature.
Overview of Yersinia pestis Metallophores: Yersiniabactin and Yersinopine
Authors: Chaaban Taghrid , Mohsen Yehya , Ezzeddine Zeinab , Ghssein Ghassan
Published: April 2023

The pathogenic anaerobic bacteria Yersinia pestis (Y. pestis), which is well known as the plague causative agent, has the ability to escape or inhibit innate immune system responses, which can result in host death even before the activation of adaptive responses. Bites from infected fleas in nature transmit Y. pestis between mammalian hosts causing bubonic plague. It was recognized that a host’s ability to retain iron is essential in fighting invading pathogens. To proliferate during infection, Y. pestis, like most bacteria, has various iron transporters that enable it to acquire iron from its hosts. The siderophore-dependent iron transport system was found to be crucial for the pathogenesis of this bacterium. Siderophores are low-molecular-weight metabolites with a high affinity for Fe3+. These compounds are produced in the surrounding environment to chelate iron. The siderophore secreted by Y. pestis is yersiniabactin (Ybt). Another metallophore produced by this bacterium, yersinopine, is of the opine type and shows similarities with both staphylopine and pseudopaline produced by Staphylococcus aureus and Pseudomonas aeruginosa, respectively. This paper sheds light on the most important aspects of the two Y. pestis metallophores as well as aerobactin a siderophore no longer secreted by this bacterium due to frameshift mutation in its genome.
Using Learner Reviews to Inform Instructional Video Design in MOOCs
Authors: Deng Ruiqi , Gao Yifan
Published: April 2023

Videos are arguably the most important and frequently used instructional resource in massive open online courses (MOOCs). Recent research has explored learners’ perceptions and preferences regarding MOOC instructional videos. However, these studies are often limited to a small number of specific courses, and few grounded theory studies have been undertaken to investigate this topic. In the present study, a multiple-coder research methodology was adopted to analyze 4534 learner reviews of MOOCs in 14 categories. The study aimed to identify key characteristics associated with learners’ favorable perceptions of MOOC videos, types of supplemental or in-video resources learners perceive helpful to support MOOC video use, and video production features learners value. Results revealed that (a) “organized”, “detailed”, “comprehensible”, “interesting”, and “practical” were the top five important characteristics associated with learners’ favorable perceptions of MOOC videos; (b) learners perceived “presentation slides”, “reading materials”, “post-video assessments”, “embedded questions”, and “case studies” as helpful resources to support their utilization of MOOC videos; and (c) learners found “duration” a more salient production feature than “editing”, “resolution”, “subtitles”, “music”, or “voice”. The findings present implications for MOOC video design and foundations for future research avenues.
The Effectiveness of Gamified Tools for Foreign Language Learning (FLL): A Systematic Review
Authors: Luo Zhanni
Published: April 2023

Gamification has emerged as a promising approach for foreign language learning (FLL), which refers to the use of game design elements to engage learners or improve academic performance. However, the features of gamification studies in FLL and their effectiveness are unclear. Additionally, how previous studies measured the effectiveness of gamified FLL tools is not well understood. In this systematic review, this author addressed these questions based on 21 empirical studies. The findings revealed that the effectiveness of gamified tools in FLL was mixed, with some bringing positive changes, others negative changes, and some showing no differences. The factors that influenced the effectiveness include methodological limitations, biases in the experiment setting, technical limitations, individual differences, failure to achieve meaningful gamification, a mixture of element selection, sub-optimal measurement, and data interpretation biases. This study identified research gaps in previous studies and offers suggestions for future research in this area.
A Conceptual Framework to Promote the Transition to Positive Mental Health among Young Construction Workers
Authors: Frimpong Samuel , Sunindijo Riza Yosia , Wang Cynthia Changxin , Boadu Elijah Frimpong , Dansoh Ayirebi
Published: April 2023

There is a need to promote the mental health and well-being of young people who work in the construction industry worldwide. Although research exists on young construction workers’ mental health, it conceptualises mental health as a disease and focuses predominantly on issues connected with negative aspects of mental health. In contrast, research that can inform the promotion and protection of positive mental health, which is crucial to young construction workers’ achievement of good mental health and well-being, is scarce. To improve this situation, it is necessary to develop frameworks that reconceptualise mental health as a positive phenomenon and provide a comprehensive picture of how positive mental health is achieved by young construction workers. In this study, therefore, we propose a conceptual framework and five testable propositions based on Meleis’ middle-range theory of transitions and Keyes’ Dual-Continuum Model, both of which focus on the attainment of well-being. The proposed framework wholistically captures the structure of the distal, intermediary, and proximal determinants of young construction workers’ positive mental health and the relationships among them. The framework and its accompanying propositions provide a basis for undertaking multi-level and context-specific research that can adequately inform the development of interventions and policies for promoting and protecting young construction workers’ positive mental health.
Study of the Freeze–Thaw Resistance for Composite Fiber Recycled Concrete with Sulphate Attack Exposure
Authors: Yuan Xiaosa , Dai Mingjiang , Li Mengfan , Liu Fang
Published: April 2023

The exposure of recycled concrete (RCA) to a sulphate environment in cold regions makes it crucial to overcome the freeze–thaw cycling effects of recycled concrete. Based on steel and basalt fiber reinforced recycled concrete, the freeze–thaw cycle resistance of recycled concrete was studied by exposure to a sulphate environment. The mass loss, dynamic elastic modulus loss and compressive strength loss of the specimens were studied through freeze–thaw cycle experiments. SEM techniques were used to explore the effect of fiber distribution on the freeze–thaw resistance of recycled concrete. The freeze–thaw mechanism of the basalt fiber and steel fiber recycled concrete exposed to a sulphate environment has also been summarized. The results show that, based on the sulphate environment, the composite fiber recycled concrete has a higher stability in terms of mass loss and relative dynamic modulus of elasticity than single fiber concrete. The compressive strength of S0.9RC (recycled concrete with 0.9% steel fibers) and BF5.5RC (recycled concrete containing 5.5 kg/m3 basalt fibers) increased by 8.62% and 13.62%, respectively, compared to normal recycled concrete after 28 days of maintenance; and after 150 freeze–thaw cycles, the compressive strength increased by 41.39% and 47.54%, respectively; compared to ordinary natural aggregate concrete, the compressive strength of S0.9RC and BF5.5RC increased by 32.90% and 27.36%, respectively. The compressive strength of the S1.5BF7.5RC (recycled concrete with 1.5% steel fibers and 7.5 kg/m3 basalt fibers) composite basalt fiber–steel fiber concrete also increased by 42.82%. SEM techniques indicated that the basalt fiber in the recycled concrete exhibited fracture damage, which inhibited the development of microcracks within the concrete. When the recycled concrete is subjected to coupled sulphate and freeze–thaw cycles, freezing occurs from the outside in, with ice crystals extending along the cracks into the matrix. Prior to freezing, a negative pressure is created by the compression of the air and the contraction of the salt solution, which pulls the external solution inwards. The brine is in a state where ice and water coexist during the continuous cooling process. The salt solution migrates from the inside to the outside during heating and melting.
Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms—Updated Classification and New Concepts
Authors: Kurz Katrin S. , Ott Michaela , Kalmbach Sabrina , Steinlein Sophia , Kalla Claudia , Horn Heike , Ott German , Staiger Annette M.
Published: April 2023

The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only representing some minor modifications in diagnostic terms. Major changes have been made in the diffuse large B-cell lymphomas (DLBCL)/high-grade B-cell lymphomas (HGBL) associated with MYC and BCL2 and/or BCL6 rearrangements. This category now consists of MYC and BCL2 rearranged cases exclusively, while the MYC/BCL6 double hit lymphomas now constitute genetic subtypes of DLBCL, not otherwise specified (NOS) or of HGBL, NOS. Other major changes are the conceptual merger of lymphomas arising in immune-privileged sites and the description of LBCL arising in the setting of immune dysregulation/deficiency. In addition, novel findings concerning underlying biological mechanisms in the pathogenesis of the different entities are provided.
Microsatellite Instability: A Review of Molecular Epidemiology and Implications for Immune Checkpoint Inhibitor Therapy
Authors: Kavun Alexandra , Veselovsky Egor , Lebedeva Alexandra , Belova Ekaterina , Kuznetsova Olesya , Yakushina Valentina , Grigoreva Tatiana , Mileyko Vladislav , Fedyanin Mikhail , Ivanov Maxim
Published: April 2023

Microsatellite instability (MSI) is one of the most important molecular characteristics of a tumor, which occurs among various tumor types. In this review article, we examine the molecular characteristics of MSI tumors, both sporadic and Lynch-associated. We also overview the risks of developing hereditary forms of cancer and potential mechanisms of tumor development in patients with Lynch syndrome. Additionally, we summarize the results of major clinical studies on the efficacy of immune checkpoint inhibitors for MSI tumors and discuss the predictive role of MSI in the context of chemotherapy and checkpoint inhibitors. Finally, we briefly discuss some of the underlying mechanisms causing therapy resistance in patients treated with immune checkpoint inhibitors.
MicroRNA, mRNA, and Proteomics Biomarkers and Therapeutic Targets for Improving Lung Cancer Treatment Outcomes
Authors: Ye Qing , Raese Rebecca , Luo Dajie , Cao Shu , Wan Ying-Wooi , Qian Yong , Guo Nancy Lan
Published: April 2023

The majority of lung cancer patients are diagnosed with metastatic disease. This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). Based on association with patient survival (n = 1016), 10 miRNAs were identified as potential tumor suppressors (hsa-miR-144, hsa-miR-195, hsa-miR-223, hsa-miR-30a, hsa-miR-30b, hsa-miR-30d, hsa-miR-335, hsa-miR-363, hsa-miR-451, and hsa-miR-99a), and 4 were identified as potential oncogenes (hsa-miR-21, hsa-miR-31, hsa-miR-411, and hsa-miR-494) in lung cancer. Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. DGKE and WDR47 were found with significant associations with responses to both systemic therapies and radiotherapy in lung cancer. Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. These findings have implications for improving lung cancer diagnosis, optimizing treatment selection, and discovering new drug options for better patient outcomes.
Erector Spinae Plane Block versus Paravertebral Block after Thoracic Surgery for Lung Cancer: A Propensity Score Study
Authors: Durey Benjamin , Djerada Zoubir , Boujibar Fairuz , Besnier Emmanuel , Montagne François , Baste Jean-Marc , Dusseaux Marie-Mélody , Compere Vincent , Clavier Thomas , Selim Jean
Published: April 2023

Introduction: The prevention of respiratory complications is a major issue after thoracic surgery for lung cancer, and requires adequate post-operative pain management. The erector spinae plane block (ESPB) may decrease post-operative pain. The objective of this study was to evaluate the impact of ESPB on pain after video or robot-assisted thoracic surgery (VATS or RATS). Methods: The main outcome of this retrospective study with a propensity score analysis (PSA) was to compare the post-operative pain at 24 h at rest and at cough between a group that received ESPB and a group that received paravertebral block (PVB). Post-operative morphine consumption at 24 h and complications were also assessed. Results: One hundred and seven patients were included: 54 in the ESPB group and 53 in the PVB group. The post-operative median pain score at rest and cough was lower in the ESPB group compared to the PVB group at 24 h (respectively, at rest 2 [1; 3.5] vs. 2 [0; 4], p = 0.0181, with PSA; ESPB −0.80 [−1.50; −0.10], p = 0.0255, and at cough (4 [3; 6] vs. 5 [4; 6], p = 0.0261, with PSA; ESPB -1.48 [−2.65; −0.31], p = 0.0135). There were no differences between groups concerning post-operative morphine consumption at 24 h and respiratory complications. Conclusions: Our results suggest that ESPB is associated with less post-operative pain at 24 h than PVB after VATS or RATS for lung cancer. Furthermore, ESPB is an acceptable and safe alternative compared to PVB.
The Transcriptome of Chicken Migratory Primordial Germ Cells Reveals Intrinsic Sex Differences and Expression of Hallmark Germ Cell Genes
Authors: Doddamani Dadakhalandar , Woodcock Mark , Taylor Lorna , Nandi Sunil , McTeir Lynn , Davey Megan G. , Smith Jacqueline , McGrew Mike J.
Published: April 2023

Primordial germ cells (PGCs) are germline-restricted embryonic cells that form the functional gametes of the adult animal. The use of avian PGCs in biobanking and producing genetically modified birds has driven research on the in vitro propagation and manipulation of these embryonic cells. In avian species, PGCs are hypothesized to be sexually undetermined at an early embryonic stage and undergo differentiation into an oocyte or spermatogonial fate dictated by extrinsic factors present in the gonad. However, chicken male and female PGCs require different culture conditions, suggesting that there are sex-specific differences, even at early stages. To understand potential differences between male and female chicken PGCs during migratory stages, we studied the transcriptomes of circulatory stage male and female PGCs propagated in a serum-free medium. We found that in vitro cultured PGCs were transcriptionally similar to their in ovo counterparts, with differences in cell proliferation pathways. Our analysis also revealed sex-specific transcriptome differences between male and female cultured PGCs, with notable differences in Smad7 and NCAM2 expression. A comparison of chicken PGCs with pluripotent and somatic cell types identified a set of genes that are exclusive to germ cells, enriched in the germplasm, and associated with germ cell development.