bluuebunny/crossref_metadata_2025 huggingface dataset:
MRI reliability in pediatric abdominal lymph node metastases?
Authors: Gülçin Bozbeyoğlu Sabriye , Perçem Orhan Söylemez Umut , Gündüz Nesrin
Published: July 2023

Background

Although positron emission tomography-computed tomography (PET-CT) is an effective imaging method used in the detection of lymph node metastases, repeated imaging increases X-ray exposure, especially in pediatric patients. Magnetic resonance imaging (MRI) may detect abdominal lymph nodes and provide subtle anatomic detail, and functional information without radiation.

Purpose

To evaluate the reliability of MRI in detecting lymph node metastases in pediatric abdominal malignancies and to determine whether X-ray dose can be reduced by comparing its effectiveness with PET-CT.

Material and Methods

Patients aged <18 years, diagnosed with abdominal malignant solid lesions between January 2015 and 2022 were included in this retrospective single-center study. A total of 14 A total of 14 different anatomic locations were defined for lymph nodes in MRI and PET-CT examinations. Cohen's kappa test was used to evaluate the consistency between PET-CT and MRI. P < 0.05 was considered statistically significant.

Results

In total, 25 patients (18 [72%] girls, 7 [28%] boys; mean age = 9.32 ± 16.9 years; age range = 1–18 years) with abdominal solid malignant tumors were included. The reliability of MRI and inter-observer reliability differed depending on the location of the lymph nodes. The reliability was almost perfect for the internal iliac (k = 0.915), porta hepatis, and aortocaval lymph node stations, while fair reliability was observed for the mesenteric lymph nodes (k = 0.525).

Conclusion

The results showed that MRI was as reliable as PET-CT in detecting some intra-abdominal metastatic lymph nodes, while its reliability was lower in some lymph node stations.
The Impact of an Expressive Writing and Storytelling Program on Ex-Offenders: A Pilot Study
Authors: Kartikaningsih Ndaru , Lawson Kelley , Mayhan Maddy , Spears Emery , Chew Olivia , Green Salaam , Tucker Sarah C. , Kirklin Kimberly , Yuen Hon K.
Published: July 2023

While storytelling or expressive writing has been studied in prisoners, little is known about the impact of these art interventions on ex-offenders. This study aims to evaluate a 6-week expressive writing and storytelling program in a group of nine ex-offenders who attend a peer support group. Quantitative data, including psychological recovery, well-being, hope, social support, and loneliness, was collected at baseline and post-program. Individual interviews were conducted at post-program. Results revealed a significant increase in participants’ psychological recovery as measured by the Recovery Assessment Scale-revised at post-program with an effect size of 0.56. Three themes about participation in the program emerged: safe space for processing and expressing inner feelings, relating to and connecting with peers, and adjusting the way of thinking. Findings showed this program has the potential to improve ex-offenders’ psychological recovery, and provide them with skills to desist from crime and be better serve as peer support workers.
Alcohol's Role in Sexual Decision Making in First-Year College Women: An Event-Level Assessment
Authors: Scaglione Nichole M. , Ward Rose Marie , Buben Alex , Turrisi Rob
Published: July 2023

Sexual decision making is often grounded in social scripts that can be detrimental to women's healthy relationships and sexual development during the transition to college. Little is known about the malleable decision-making processes and drinking behaviors that influence sexual behaviors from day-to-day. We examined whether women were more likely to engage in sexual behaviors on days they had higher intentions and willingness to engage in sex or drink alcohol. We also explored interactions between sex- and alcohol-related decision constructs. Eighty-two first-year college women completed 14 days of ecological momentary assessment, reporting on alcohol- and sex-related intentions and willingness (3x daily) and daily drinking and sexual behaviors. We found partial support for our hypotheses: intentions and willingness to have sex were positively associated with sex behaviors, but the willingness to drink was negatively associated with sex behaviors. Heavy drinking was associated with sexual behavior, even when women indicated no prior willingness to engage in sexual behavior on those days. Findings highlight the need to address event-level variability in sexual decision making, with a particular focus on how alcohol impacts these processes. Further, the robust association between sexual intentions and behavior suggests intention setting may be a particularly useful sexual empowerment education tool.
Adverse Childhood Experiences and Quality of Life: A Mediating Role of Physical Activity
Authors: Parrish Loni J. , Chroust Alyson J.
Published: July 2023

Purpose

Examine whether barriers to physical activity (PA) and PA level serve as serial mediators to the relationship between adverse childhood experiences (ACEs) and perceived quality of physical health. Design: Cross-sectional. Setting: A public university in Southeast United States.

Subjects

Seventy-five participants (18- 49 years). Measures: Self-report measures related to ACEs, barriers to PA, amount of PA, and perceived quality of physical health.

Analysis

Serial mediation analysis. Barriers to PA was a first-order mediator, and PA level was a second-order mediator between ACEs and perceived quality of physical health.

Results

Barriers to PA and PA levels serially mediated the relationship between ACEs and perceived quality of physical health (c = −1.01, SE = .251, P = .0002, 95% CI [−1.50, −.499]). The direct effect of ACEs on perceived quality of physical health was nonsignificant when mediators were controlled (c’ = −.383, SE = .252, P = .133, 95% CI [−.886, .120]). Higher ACE scores were associated with more barriers to PA, lower PA levels, and in turn, lower perceived quality of physical health.

Conclusion

The current study highlights specific pathways that contribute to the relationship between ACEs and perceived quality of physical health. Albeit limited by the sample size, preliminary data support prioritization of interventions that reduce barriers to PA when trying to increase PA in populations that are prone to early adversity.
The challenges of developing sustainable cultural and creative ecosystems and the role of higher education institutions: Lessons from Dundee and Chatham, UK
Authors: Dent Tamsyn , England Lauren , Comunian Roberta
Published: July 2023

This paper feeds into scholarly interest on place-based creative industrial development. It considers the creative-led economic development of two UK cities, Dundee and Chatham as emerging through a series of interdependent relationships between locally based higher education institutions (HEIs) and cultural and creative industries (CCIs) that are connected as part of a cultural and creative ecosystem (CCE). The discussion reflects on how interconnecting collaborations foster platforms and networks that support a sustainable CCE. Based on the research findings from qualitative investigations within each city, the paper applies the capability approach as a methodological tool to investigate how resources can be converted into tangible, accessible opportunities for local communities. The approach illustrates the need to focus on the resources that connect HEIs to CCIs within a geographical location for sustainable development. It concludes with a series of policy recommendations aimed at local governments to develop more integrated, ecological leadership models and policies to support sustainable CCEs.
Clinicopathological and molecular approaches to the diagnosis of oral lesions in Mpox: Case report
Authors: Ramírez-Amador Velia , Figueroa-Ramos Alexia , Valencia-Mayoral Pedro , Mayo-Rangel Angélica , Anaya-Saavedra Gabriela
Published: July 2023

Mpox virus infection (MPXV) has recently been recognized as a public health emergency by the World Health Organization. While several studies have described the clinical characteristics of MPXV-oral lesions, there remains a dearth of information regarding the histological and ultrastructural oral findings. A 24-year-old HIV-positive man presented with a shallow ulcer, covered by a fibrinoid membrane, and surrounded by an erythematous halo in the hard and soft palate. The clinical appearance of the lesion raised suspicion of a viral infection; thus, the diagnosis was based on histological and electronic microscopy findings and confirmed by RT-PCR testing in the skin specimen. This case report aims to offer comprehensive insights into the clinical, histopathological, and ultrastructural features of oral lesions caused by MPXV in an individual with HIV. This report provides valuable information about the characteristics of MPXV infection in the oral mucosa, particularly in people living with HIV.
Study on the adsorption mechanism of the sodium lignosulphonate on the surface of the selected plastics as a potential solution for plastics waste management
Authors: Shariatikia Fateme , Ostad Movahed Saeed , Ostad Movahed Nadia
Published: July 2023

Separating different components of a plastic mixture is crucial in its recycling. Among the different separation techniques, flotation was selected as a cheap, non-toxic, and efficient process. Basis of the technique refers to the selective adsorption of a depressant on the plastics surface which cause the alteration in the surface energy of the plastic. Adsorption of the lignosulfonic acid sodium salt (SL) on the surface of the selected available plastics in the waste stream was studied. Plastics used in this study were Polyvinylchloride (PVC), acrylonitrile-butadiene-styrene polymer (ABS), polystyrene (PS), polypropylene (PP), polyoxymethylene (POM), and polycarbonate PC. It results showed that SL adsorbed on the surface of the selected plastics considerably. It was evidenced by the measured equilibrium adsorption capacities ( [Formula: see text] ) of the SL and also, the SEM and AFM images. SL adsorbed on the plastic surface in the sequence of [Formula: see text]. Also, the parameters of the Freundlich and Langmuir adsorption models were derived. Experimental data fit with the mentioned models appropriately. However, for the most studied plastics, the Freundlich model was more suitable. As important conclusion, PP separated from plastics mix using the flotation separation technique with the aid of SL as a depressant.
Instructor Perspectives on Mobile Technologies and Social Media in Practice: Findings From the United Kingdom's Outward Bound Trust
Authors: Reed Jack
Published: July 2023

Background: The use or non-use of mobile technologies and social media in residential outdoor adventurous education (OAE) remains contested and generates an often-cited for-and-against argument in both theory and practice. Purpose: This qualitative study explored instructor perceptions of mobile technologies and social media in their practice as members of instructional staff at the United Kingdom's Outward Bound Trust. Methodology/Approach: Grounded within a multiple-case study design, 20 members of instructional staff were interviewed online from three Outward Bound Trust centers across Wales, England, and Scotland. Findings/Conclusions: Two major themes are shared as statements: (1) phone-free outdoor experiences are more impactful for young people in contemporary society; (2) social media is fake, outdoor adventurous education necessitates in-person and in-place interaction. These findings are presented within a postdigital conceptual lens which questions whether any residential outdoor experience can be truly “technology free.” Implications: The study consolidates perspectives on mobile technologies and social media in the practices of residential OAE instructors. These perspectives are considered important in the framing and delivery of contemporary OAE practice.
An analytic solution of an arbitrary location through-crack emanating from a nano-circular hole in one-dimensional hexagonal piezoelectric quasicrystals
Authors: Xin Yuyan , Xiao Junhua
Published: July 2023

The mode III fracture performance of an arbitrary location through-crack at the edge of a nano-circular hole in one-dimensional hexagonal quasicrystals is studied. Based on the G-M elasticity theory, the piezoelectric quasicrystal theory and the boundary value problems theory, the phonon, phason and electric fields of the nano-defects (nano-hole and nano-cracks) are obtained, and the analytic expressions of the field intensity factors at both ends of through-crack are present. The present solution can be degenerated into the existing results. The relationship between the field intensity factors with the nano-defects related parameters, far-field loads and piezoelectric quasicrystal coupling coefficient are discussed. The field intensity factors have obvious size effects when the defects size is at nanoscale and the surface effect is considered. The field intensity factors tend to be classical theory with the increase in defect size. The field intensity factors show different changes with the increase in crack location angle and relative size between cracks. The size effect of the field intensity factors is significantly affected by the crack location. The far-field mechanical-electric loads and the piezoelectric quasicrystal coupling coefficient have obvious influence on the field intensity factors.
Catheter related atrial thrombus caused by Abiotrophia defectiva: A case series and review of literature
Authors: Mathew Gerry George , Kompella Kiran Kumar , Jayabalan Rajamahesh , Rajkumar Venkatesh
Published: July 2023

Catheter related atrial thrombus (CRAT) is a devastating complication associated with tunneled hemodialysis catheter. Abiotrophia defectiva is a rare fastidious pathogen implicated predominantly in culture negative infective endocarditis. Here we report three cases of CRAT in maintenance hemodialysis patients with variable clinical presentation caused by Abiotrophia defectiva. Video assisted thoracoscopic retrieval of atrial thrombus is a novel technique which is scarcely reported in medical literature for surgical management of large atrial thrombus. Our cases were managed by timely administration of antibiotics and anticoagulants followed by surgical retrieval of atrial thrombus with removal of tunneled dialysis catheter. This case series illustrates the importance of prompt diagnosis, appropriate anticoagulation with antibiotics, and mini-invasive surgical removal of atrial thrombus for the management of CRAT.
For sled dogs and women: Hormonal contraception and animacy hierarchies in Danish/Greenlandic Depo-Provera debates
Authors: Bang Anne N , Kroløkke Charlotte H
Published: July 2023

Empirically centring the hitherto unexplored mainstream Danish-Greenlandic Depo-Provera media debate, in this article, we show how syringes of synthetic progesterone circulated across bodies, borders, generations, and species to reproduce and disrupt animacy hierarchies in ‘post-colonial’ times. Feminist scholars have attended to the reproductive injustices revealed in the unequal global distribution of Depo-Provera. However, these critiques have not been brought into conversation with recent environmental humanities scholarship tracing toxic relationalities and their connections to toxic power hierarchies such as settler colonialism. This article connects this scholarship by foregrounding the ways in which birth control injections not only worked on feminised bodies to prevent pregnancies but also to highlight – and further expose – subordinated groups of reproductive subjects, rendered abnormal on the basis of ideas about agency and cognitive ability. To be treated with Depo-Provera was, in the debates, to be marked as Other – and to be marked as Other was to be marked as a candidate for ‘The Shot’.
Keeping It Real in Chinese Hip-Hop: Everyday Authenticity and Coming From the Street
Authors: Wang Yehan
Published: July 2023

The status of hip-hop in China is being reshaped by the sudden popularity experienced by the genre in the last few years. An aspect that has been overlooked by scholarly research on Chinese hip-hop authenticity is that underground rappers may have to simultaneously assume multiple personal, professional, and social roles while attempting to maintain authenticity. This article provides an empirical account of how authenticity and the ‘keep it real’ motto are understood and negotiated by underground Chinese rappers. Drawing from in-depth interviews with 12 rappers, this article proposes the notion of everyday authenticity as a means for rappers to draw inspiration from unembellished daily realities while also using music to alleviate everyday hardships. The article also examines the challenges faced by underground rappers in the attempt to retain this type of authenticity in the mainstream, commercially driven environment. The tension is resolved by creating an autonomous realm for rappers that come ‘out of the street’, which allows rappers to claim legitimacy inside and outside the underground. This article provides an extension of the conceptualisation of authenticity in the Chinese hip-hop context, thus critically contributing to the global debate around hip-hop authenticity.
A feasibility study of various joining techniques for three-dimensional printed polylactic acid and wood-reinforced polylactic acid biocomposite
Authors: Palaniyappan Sabarinathan , Sivakumar Narain Kumar , Bodaghi Mahdi , Kumar Madhan , Rahaman Mostafizur
Published: July 2023

The current research assesses various joining techniques such as an adhesive bond, direct three-dimensional printing, and ultrasonic welding for dissimilar three-dimensional printed thermoplastics such as polylactic acid and wood-reinforced polylactic acid biocomposite. This study is the first of its kind to determine an effective technique for joining three-dimensional printed polylactic acid/wood-polylactic acid profiles. Mechanical responses such as lap shear strength and shore D hardness of the various joints are investigated and compared experimentally. The results highlight that 15%–17% higher shear strength can be obtained for ultrasonically welded joints compared with direct three-dimensional printing of polylactic acid and wood polylactic acid lap joints. The macroscopic investigation of the ultrasonic welded polymeric joint exhibits a good level of melting of polymers and wetting in the interface. This results in an inter-molecular diffusion of polymeric chains and entanglement of polymers under respective conditions.
Political corruption in unjust regimes
Authors: Fabre Cécile
Published: July 2023

A theory of political corruption must give a plausible descriptive account of what counts as politically corrupt conduct, and a plausible normative account of the reasons why (if any) such conduct is wrongful, and distinctively so. On Ceva and Ferretti's sophisticated descriptive and normative account of corruption if and only if the act is carried out by a public official acting in her capacity as officeholder, and she knowingly acts to ends which are not congruent with the terms of her mandate. By their own admission, Ceva and Ferretti focus for the most part on just, or nearly just, regimes – which include democratic regimes. In this paper, I probe the strength and implications of their account for political corruption in clearly unjust regimes, in which individuals’ basic civil, political and socio-economic rights are routinely and systematically violated. I argue that their account does not straightforwardly apply to these cases, and that their cursory treatment of all-things-considered justified corruption in those regimes exposes a gap in their account of corruption.
Physician Modification of a Custom-Made Fenestrated Endograft By Closure of a Fenestration With Bovine Patch
Authors: Becker D. , Ali A. , Prendes C. , Stavroulakis K. , Stana J. , Tsilimparis N.
Published: July 2023

Purpose:

Ruptured mycotic pararenal aortic aneurysms are rare and serious condition that requires prompt treatment. Open surgery with aortic resection and in-situ or extra-anatomic reconstruction is the standard treatment. The aim of this technical note is to report urgent endovascular treatment using a readily available custom-made device (created for another patient), with a back-table modification using pericardium patch and a new fenestration.

Technique:

In preoperative measurements on centerline-based workstation, aortic diameter in proximal and distal landing zone and target vessel position matched the measurements of graft plan of custom-made device (CMD) besides left renal artery. To address current patient`s anatomy, closure of the nonsuitable fenestration with pericardial patch and creation of new fenestration (1 cm above and 1:15 hours posterior to original fenestration) for the respective target vessel have been performed. Postoperative computed tomography angiography (CTA) scan showed complete exclusion of aneurysm, perfused target vessels, and no endoleak. Under resistance-based antibiotic therapy, the patient was asymptomatic and showed normal infection parameters in blood samples postoperatively.

Conclusion:

In the hands of an experienced endovascular aortic surgeon modification of a custom-made device is a quick and feasible technique in this emergency situation. Long-term follow-up must confirm the durability and reliability of this new technique.

Clinical Impact:

The described technique of modification of a custom-made endograft can provide an alternative endovascular treatment option for urgent complex abdominal aortic pathologies. Compared to the current available treatment modalities, like physician modified endografts, off-the-shelf branched devices, parallel grafts and in-situ fenestration, it can save considerable time and provides reasonable sealing in ruptured cases. The technique offers a valuable add-on to the armamentarium of experienced endovascular physicians.
URNet: System for recommending referrals for community screening of diabetic retinopathy based on deep learning
Authors: Yang Kun , Lu Yufei , Xue Linyan , Yang Yueting , Chang Shilong , Zhou Chuanqing
Published: July 2023

Diabetic retinopathy (DR) will cause blindness if the detection and treatment are not carried out in the early stages. To create an effective treatment strategy, the severity of the disease must first be divided into referral-warranted diabetic retinopathy (RWDR) and non-referral diabetic retinopathy (NRDR). However, there are usually no sufficient fundus examinations due to lack of professional service in the communities, particularly in the developing countries. In this study, we introduce UGAN_Resnet_CBAM (URNet; UGAN is a generative adversarial network that uses Unet for feature extraction), a two-stage end-to-end deep learning technique for the automatic detection of diabetic retinopathy. The characteristics of DDR fundus data set were used to design an adaptive image preprocessing module in the first stage. Gradient-weighted Class Activation Mapping (Grad-CAM) and t-distribution and stochastic neighbor embedding (t-SNE) were used as the evaluation indices to analyze the preprocessing results. In the second stage, we enhanced the performance of the Resnet50 network by integrating the convolutional block attention module (CBAM). The outcomes demonstrate that our proposed solution outperformed other current structures, achieving 94.5% and 94.4% precisions, and 96.2% and 91.9% recall for NRDR and RWDR, respectively.
Assessing Diet and Musculoskeletal Pain in Adults: Results From a Cross-Sectional Analysis of the National Health and Nutrition Examination Survey (NHANES)
Authors: Tonelli Enrico Valerio , Hébert James R. , Mugford Gerald , Gao Zhiwei , Wang Peter , Shivappa Nitin , Sowa Gwendolyn
Published: July 2023

Musculoskeletal (MSK) pain is highly prevalent worldwide and is associated with high levels of disability. Systemic inflammation may contribute to MSK pain, and diet is a crucial modulator of systemic inflammation. The Dietary Inflammatory Index (DII®) assesses the tendency of diets to cause inflammation. Higher DII scores, indicating pro-inflammatory diets, were hypothesized to be associated with a higher prevalence of MSK pain symptoms and duration. Data from 4118 subjects from the 2003-2004 NHANES survey were included to assess the association between DII scores and the presence and duration of osteoarthritis symptoms and neck and low back pain. After adjusting for potential confounders, the multivariable analysis showed that DII scores were significantly associated ( P < .05) with increased risk of osteoarthritis symptoms (joint pain, aching, and stiffness) in the past year (OR = 1.099; 95% CI 1.029,1.174), low back pain (OR = 1.070; 95% CI 1.003,1.142), and any pain lasting longer than 24 hours (OR = 1.128; 95% CI 1.046,1.216). Neck pain and pain duration were not significantly associated with DII scores. These findings suggest a significant association between a pro-inflammatory diet and the presence of different MSK pains (joint pain and low back pain) and with pain lasting longer than 24 hours.
A magnetic field-circuit coupling model for functionality and interface simulation test of railway Balise
Authors: Li Zhengjiao , Zhao Zishuo , Liu Jiang , Cai Baigen , Lu Debiao
Published: July 2023

Railway Balise is widely used in the Balise-based train control system to provide accurate location information for the safe operation of trains. In order to evaluate and analyze the functionality and interface test of a new designed Balise more rigorously and accurately, this paper build a magnetic field-circuit coupling model to quantify the internal physical function and external interface performance of the Balise. Based on the electromagnetic field theory, the down-link and up-link magnetic field models were set up which describes the relationship between the Balise and the test antenna. Then based on the equivalent circuit model, the energy conversion circuit model and the data transmission circuit model were derived, and the complete coupling model is established for functionality and interface simulation tests. Moreover, the physical behavior and interface characteristic of Balise in different situations are validated and analyzed, followed by the analysis of magnetic field conformity, I/O characteristics, impedance, start-up behavior, and up-link signal characteristics. The results show the start-up time of the Balise functionality test decreases with increasing down-link magnetic field. Furthermore, Balise impedance can be used as a new dynamic detection parameter of the Balise. Finally, the down-link magnetic field will slightly affect the uplink signal characteristics.
Targeting an elevated FVIII level using personalized rurioctocog alfa pegol prophylaxis in specific patient populations with hemophilia A: post hoc subanalysis of the randomized, phase 3 PROPEL study
Authors: Escuriola-Ettingshausen Carmen , Klamroth Robert , Escobar Miguel , Stasyshyn Oleksandra , Tangada Srilatha , Engl Werner , Honauer Ivan , Lee Hye-Youn , Chowdary Pratima , Windyga Jerzy
Published: July 2023

Background:

The phase 3, prospective PROPEL study demonstrated that pharmacokinetic (PK)-guided prophylaxis targeting elevated factor VIII (FVIII) troughs in patients with hemophilia A resulted in lower annualized bleeding rates (ABRs) and a higher proportion of patients experiencing zero bleeds in the second 6 months of treatment when targeting a FVIII trough of 8–12% versus 1–3%.

Objective:

To investigate the benefit of PK-guided prophylaxis with rurioctocog alfa pegol targeting two FVIII trough levels in specific patient subgroups in a post hoc analysis using data from PROPEL.

Design:

This is a post hoc analysis of data from the PROPEL study. The design and primary outcomes of the prospective, randomized PROPEL study (NCT02585960) have been reported previously.

Methods:

This post hoc analysis reports data stratified by FVIII half-life ( t1/2), hemophilic arthropathy status, number of target joints at screening, previous treatment regimen, and ABR range in the 12 months before study entry.

Results:

Targeting an elevated FVIII trough of 8–12% was associated with higher average FVIII levels over time, regardless of FVIII t1/2 at baseline. The decrease in total ABR between the 8–12% and 1–3% arms was greatest in patients with a FVIII t1/2 of 6 to <12 h (0.7 versus 3.5); a higher number of target joints, that is, at least four target joints, at baseline (0.2 versus 1.6); the presence of arthropathy (0.1 versus 1.7); and those previously treated on-demand (0.3 versus 1.8).

Conclusion:

These results support the feasibility of targeting elevated FVIII levels using personalized rurioctocog alfa pegol prophylaxis. These benefits may be especially important in patients with a short FVIII t1/2 and those receiving standard prophylaxis with frequent breakthrough bleeds, arthropathy, and target joints.

Registration:

ClinicalTrials.gov Identifier: NCT02585960; https://clinicaltrials.gov/ct2/show/NCT02585960
Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies
Authors: Guo Ruoyi , Zhuang Hanjie , Chen Xiuning , Ben Yulong , Fan Minjie , Wang Yiwei , Zheng Pengfei
Published: July 2023

The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.
Generalizing factors of COVID-19 vaccine attitudes in different regions: A summary generation and topic modeling approach
Authors: Liu Yang , Shi Jiale , Zhao Chenxu , Zhang Chengzhi
Published: July 2023

Objective

The goal of this study is to use summary generation and topic modeling to identify factors contributing to vaccine attitudes for three different vaccine brands, with the aim of generalizing these factors across different regions.

Methods

A total of 5562 tweets about three vaccine brands (Sinovac, AstraZeneca, and Pfizer) were collected from 14 December 2020 to 30 December 2021. BERTopic clustering is used to group the tweets into topics, and then contrastive learning (CL) is adopted to generate summaries of each topic. The main content of each topic is generalized into three factors that contribute to vaccine attitudes: vaccine-related factors, health system-related factors, and individual social attributes.

Results

BERTopic clustering outperforms Latent Dirichlet Allocation clustering in our analysis. It can also be found that using CL for summary generation helped to better model the topics, particularly at the center-point of the clustering. Our model identifies three main factors contributing to vaccine attitudes that are consistent across different regions.

Conclusions

Our study demonstrates the effectiveness of deep learning methods for identifying factors contributing to vaccine attitudes in different regions. By determining these factors, policymakers and medical institutions can develop more effective strategies for addressing concerns related to the vaccination process.
Integrating Computational Data Science in University Curriculum for the New Generation of Scientists
Authors: Renu N. , Sunil K.
Published: July 2023

Integration of computational data science (CDS) into the university curriculum offers several advantages for students, faculty and the institution. This article discusses the benefits to students of introducing CDS into the university curriculum with a focus on developing skills in cheminformatics, data analysis, structure–activity relationships, modelling and simulation. Moreover, CDS can enable students to engage with complex chemical and toxicological data in new and dynamic ways, helping them to develop a more nuanced understanding of the potential hazards and risks associated with different chemicals and substances. On the other hand, it can foster greater collaboration between students and faculty and with external partners in industry and government. This can lead to the development of more effective and efficient toxicological testing methods and tools to screen chemicals for potential hazards and aid the development of environmentally friendly chemicals. Overall, the integration of CDS into the university curriculum will help prepare the next generation of scientists giving them a competitive edge to make considerable contributions to green chemistry, designing safer chemicals and non-animal testing methods. It will enable them to tackle modern challenges facing society including identifying safer and more sustainable chemicals and predicting the health and environmental impacts of novel chemical substances.
The Hybrid Transtibial Technique Using the LARS Device in Primary Anterior Cruciate Ligament Reconstruction
Authors: Huang Xian-Cheng , Wang Shuang , Li Jia-Tong , Lu Wen-Qian , Luo Yong , Yang Qing-Jun , Zhang Xin-Tao , You Tian
Published: July 2023

Background:

The recently published hybrid transtibial technique (HTT) using the Pathfinder Guide with a flexible transtibial technique (TT) guide wire may represent a beneficial combination of both the anteromedial portal and TT technique. The HTT has been described as especially suitable for anterior cruciate ligament (ACL) reconstruction in adolescents or ACL revision. However, we also found that the HTT worked for primary ACL reconstruction in adults also using the Ligament Advanced Reinforcement System (LARS).

Indications:

Acute ACL rupture in active patients who are eager to return to sports quickly.

Technique Description:

The HTT combined with the conventional LARS reconstruction procedure improves the placement of the femoral tunnel, which involves a guiding vessel clamp through the anteromedial portal combined with a 2.0 mm Kirschner wire via the tibial tunnel. Finally, we used a metal screw for fixation of the ligament.

Results:

The patient experienced satisfactory reconstruction of his ACL and regained active range of motion in 1 month and a full return to sports in 6 months.

Discussion/Conclusion:

The HTT using the LARS for primary ACL reconstruction is easy, safe, and reproducible. This combined technique has not yet been published and it may provide good functional results that allow patients to recover quickly and return to sports as soon as possible.

Patient Consent Disclosure Statement:

The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
MYD88L265P augments proximal B-cell receptor signaling in large B-cell lymphomas via an interaction with DOCK8
Authors: Mandato Elisa , Yan Qingsheng , Ouyang Jing , Paczkowska Julia , Qin Yan , Hao Yansheng , Bojarczuk Kamil , Hansen Julia , Chapuy Björn , Rodig Scott J. , Khan Sumbul Jawed , Redd Robert A. , Shipp Margaret A.
Published: July 2023

Diffuse large B-cell lymphoma (DLBCL) is a clinically and genetically heterogeneous disease with at least 5 recognized molecular subtypes. Cluster 5 (C5)/MCD tumors frequently exhibit concurrent alterations in the toll-like receptor (TLR) and B-cell receptor (BCR) pathway members, MYD88L265P and CD79B, and have a less favorable prognosis. In healthy B cells, the synergy between TLR and BCR signaling pathways integrates innate and adaptive immune responses and augments downstream NF-κB activation. In addition, physiologic TLR9 pathway engagement via MYD88, protein tyrosine kinase 2 (PYK2), and dedicator of cytokinesis 8 (DOCK8) increases proximal BCR signaling in healthy murine B cells. Although C5/MCD DLBCLs are selectively sensitive to Bruton tyrosine kinase (BTK) inhibition in in vitro studies and certain clinical trials, the role of mutated MYD88 in proximal BCR signaling remains undefined. Using engineered DLBCL cell line models, we found that concurrent MYD88L265P and CD79B alterations significantly increased the magnitude and duration of proximal BCR signaling, at the level of spleen tyrosine kinase and BTK, and augmented PYK2-dependent DOCK8 phosphorylation. MYD88L265P DLBCLs have significantly increased colocalization of DOCK8 with both MYD88 and the proximal BCR-associated Src kinase, LYN, in comparison with MYD88WT DLBCLs, implicating DOCK8 in MYD88L265P/proximal BCR cross talk. Additionally, DOCK8 depletion selectively decreased proximal BCR signaling, cellular proliferation, and viability of DLBCLs with endogenous MYD88L265P/CD79BY196F alterations and increased the efficacy of BTK blockade in these lymphomas. Therefore, MYD88L265P/DOCK8-enhanced proximal BCR signaling is a likely mechanism for the increased sensitivity of C5/MCD DLBCLs to BTK blockade.
The role of the MDM2/p53 axis in antitumor immune responses
Authors: Brummer Tilman , Zeiser Robert
Published: July 2023

Mouse double minute 2 homolog (MDM2) is a negative regulator of the tumor suppressor p53 and is often highly expressed in acute myeloid leukemia (AML) and other solid tumors. Inactivating mutations in TP53, the gene encoding p53, confers an unfavorable prognosis in AML and increases the risk for relapse after allogeneic hematopoietic cell transplantation. We review the concept that manipulation of MDM2 and p53 could enhance immunogenicity of AML and solid tumor cells. Additionally, we discuss the mechanisms by which MDM2 and p53 regulate the expression of major histocompatibility complex class I and II, transcription of double stranded RNA of endogenous retroviruses, responses of interferons, production of interleukin-15, and expression of tumor necrosis factor–related apoptosis–inducing ligand receptor 1 and 2 on malignant cells. The direct effects of MDM2 inhibition or MDM2 deletion in effector T cells are discussed in the context of cancer immunotherapy. The preclinical findings are connected to clinical studies using MDM2 inhibition to enhance antitumor immunity in patients. This review summarizes current evidence supporting the use of MDM2 inhibition to restore p53 as well as the direct effects of MDM2 inhibition on T cells as an emerging concept for combined antitumor immunotherapy against hematological malignancies and beyond.
Chemical restraint as behavioural euthanasia: case studies from the Royal Commission into Aged Care Quality and Safety
Authors: Cain Patricia , Chejor Pelden , Porock Davina
Published: July 2023

Background

The prescription of psychotropic medication to older people living with dementia in residential aged care has become an increasing concern. The use of prescription medication is often prefaced as a way of preventing harm to self and others. However, the use of such medications has been considered a way of managing some of the behavioural and psychological symptoms of dementia. Using a large secondary data set, this study aimed to identify the precursors and mediating factors that influence the use of chemical restraint of older people in residential aged care.

Methods

Publicly available documents from the Australian Royal Commission into Aged Care Quality and Safety were used as the data corpus for this study. Keywords were used to search over 7000 documents to extract a set of topic-related content. We identified the cases of seven people in respite or permanent residential aged care who had been prescribed or administered psychotropic medication under circumstances that appeared to demonstrate chemical restraint. All documents relating to the cases were collated for our data set. A descriptive case study approach to analysis was taken.

Results

Four key descriptive patterns were identified: labelling and limits to tolerance, pushing prescription as a solution, coverups and avoiding consent, and family’s fight for liberty. Triangulation across the data and academic literature supports the findings.

Conclusion

Our findings provide some insight into how chemical restrain happens. Featuring throughout the cases were reports of a lack of workforce capacity to care for and support residents exhibiting dementia behaviours. Prescription of psychotropic medications featured as a “first resort” care solution. Family and friends found such approaches to care unacceptable and frequently challenged the practice. Where consent for prescription was explicitly denied, more covert approaches are demonstrated. Family awareness, presence, and advocacy were key to challenging the practice of chemical restraint. Shortfalls in the capacity of the current workforce come into play here. However, workforce shortcomings can no longer mask this ubiquitous practice. Just as importantly the spotlight needs to be turned on the prescribers and the providers.
The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis
Authors: Salari Nader , Hasheminezhad Razie , Sedighi Tabassom , Zarei Hosna , Shohaimi Shamarina , Mohammadi Masoud
Published: July 2023

Background

Obesity is a pressing public health risk issue worldwide. Women, in particular, face a higher risk of obesity. Recent research has highlighted the association between obesity and female sexual dysfunction. Therefore, the objective of this study is to investigate the global prevalence of sexual dysfunction in obese and overweight women through a systematic review and meta-analysis.

Methods

In this study, a systematic search was conducted across electronic databases, including PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar. The search aimed to identify studies published between December 2000 and August 2022 that reported metabolic syndrome's impact on female sexual dysfunction.

Results

The review included nine studies with a sample size of 1508 obese women. The I2 heterogeneity index indicated high heterogeneity (I2: 97.5). As a result, the random effects method was used to analyze the data. Based on this meta-analysis, the prevalence of sexual dysfunction in women with obesity was reported as 49.7% (95%CI: 35.8–63.5). Furthermore, the review comprised five studies involving 1411 overweight women. The I2 heterogeneity test demonstrated high heterogeneity (I2: 96.6). Consequently, the random effects model was used to analyze the results. According to the meta-analysis, the prevalence of sexual dysfunction in overweight women was 26.9% (95% CI: 13.5–46.5).

Conclusion

Based on the results of this study, it has been reported that being overweight and particularly obese is an important factor affecting women's sexual dysfunction. Therefore, health policymakers must acknowledge the significance of this issue in order to raise awareness in society about its detrimental effect on the female population.
Knowledge, behaviours, and training related to 2SLGBTQIA+ health education amongst entry-level physiotherapy students in Canada: results of a nationwide, cross-sectional survey
Authors: Primeau Codie A. , Philpott Holly T. , Vader Kyle , Unger Janelle , Le Christina Y. , Birmingham Trevor B. , MacDermid Joy C.
Published: July 2023

Background

Individuals who identify as 2SLGBTQIA+ report worse health outcomes than heterosexual/cisgender counterparts, in part due to poor experiences with healthcare professionals. This may stem from inadequate 2SLGBTQIA+ health and inclusiveness training in health professional student education. The purpose of the study was to evaluate knowledge, behaviours, and training related to 2SLGBTQIA+ health education and inclusiveness for entry-level physiotherapy students in Canada.

Methods

We conducted a nationwide, cross-sectional survey with physiotherapy students from accredited Canadian physiotherapy programs. We administered the survey through Qualtrics and recruited students through targeted recruitment emails and social media posts on Twitter and Instagram between August and December 2021. Survey responses are reported as frequencies (percentage). We also completed multivariable logistic regressions to evaluate associations among question responses related to working with 2SLGBTQIA+ individuals (i.e., communication, feeling prepared and assessment competency). Covariates included training hours (< 10/10 + hours) and 2SLGBTQIA+ identity (yes/no).

Results

A total of 150 students responded to the survey, with 35 (23%) identifying as 2SLGBTQIA+ . Many students felt confident in communicating effectively with clients who identify as 2SLGBTQIA+ (69%). However, only half (47%) felt comfortable assessing clients who identify as 2SLGBTQIA+ . Routine practice of inclusive behaviours such as using pronouns, considering identities are fluid and a patient’s gender identity and/or sexual orientation may shift from one visit to the next, and considering trauma-informed care practices were reported from less than half of the students (< 45%). Around 29% of students reported no 2SLGBTQIA+ training in their physiotherapy program, while 47% reported 0–10 hours, and 24% reported 10 + hours of training. Students with 10 + hours of training had 92% higher odds of feeling competent in assessing 2SLGBTQIA+ clients, compared to those with < 10 hours of training.

Conclusions

Entry-level physiotherapy students in Canada show a lack of understanding and awareness for 2SLGBTQIA+ health and inclusive behaviours which can meaningfully impact patient experience. Students report feeling incompetent when working with 2SLGBTQIA+ patients, which may be associated with lack of 2SLGBTQIA+ training in their programs. Greater efforts and attention towards increasing 2SLGBTQIA+ health education and inclusivity in Canadian entry-level physiotherapy programs is critically needed.
Feasibility and reproducibility of semi-automated longitudinal strain analysis: a comparative study with conventional manual strain analysis
Authors: Peng Gui-juan , Luo Shu-yu , Zhong Xiao-fang , Lin Xiao-xuan , Zheng Ying-qi , Xu Jin-feng , Liu Ying-ying , Chen Li-xin
Published: July 2023

Background

Conventional approach to myocardial strain analysis relies on a software designed for the left ventricle (LV) which is complex and time-consuming and is not specific for right ventricular (RV) and left atrial (LA) assessment. This study compared this conventional manual approach to strain evaluation with a novel semi-automatic analysis of myocardial strain, which is also chamber-specific.

Methods

Two experienced observers used the AutoStrain software and manual QLab analysis to measure the LV, RV and LA strains in 152 healthy volunteers. Fifty cases were randomly selected for timing evaluation.

Results

No significant differences in LV global longitudinal strain (LVGLS) were observed between the two methods (-21.0% ± 2.5% vs. -20.8% ± 2.4%, p = 0.230). Conversely, RV longitudinal free wall strain (RVFWS) and LA longitudinal strain during the reservoir phase (LASr) measured by the semi-automatic software differed from the manual analysis (RVFWS: -26.4% ± 4.8% vs. -31.3% ± 5.8%, p < 0.001; LAS: 48.0% ± 10.0% vs. 37.6% ± 9.9%, p < 0.001). Bland–Altman analysis showed a mean error of 0.1%, 4.9%, and 10.5% for LVGLS, RVFWS, and LASr, respectively, with limits of agreement of -2.9,2.6%, -8.1,17.9%, and -12.3,33.3%, respectively. The semi-automatic method had a significantly shorter strain analysis time compared with the manual method.

Conclusions

The novel semi-automatic strain analysis has the potential to improve efficiency in measurement of longitudinal myocardial strain. It shows good agreement with manual analysis for LV strain measurement.

Graphical Abstract