bluuebunny/crossref_metadata_2025 huggingface dataset:
Wisata Perdesaan Berbasis Kebudayaan Masyarakat Desa Lamajang
Authors:   Sekolah Tinggi Pariwisata Bogor, Jalan Siaga No 12, Bogor, Jawa Barat, Indonesia, Utami Nisa Rahmaniyah , Rahadian Wildan Rizky ,   Sekolah Tinggi Pariwisata Bogor, Jalan Siaga No 12, Bogor, Jawa Barat, Indonesia
Published: January 2024

This research aims to determine the shape & model of Lamajang village tourist. Rural tourism is a form of tourism in rural areas there are village community traditions, historical relics, art, and people's lifestyles along with the values that have been inherited passed down from generation to generation. The main attraction of the village Lamajang Village's tourism is a cultural and tourist attraction community activities. Rural tourism is a type of tourism that utilizes local resources in the form of culture and community activities. This research uses descriptive research methods with a qualitative approach. Lamajang Village has several potentials that can also be developed as an attraction, namely natural tourism in the form of a waterfall (waterfalls) and hiking trails that can be used as special routes an interesting tourist route through natural exploration activities. Rural tourism in Lamajang Village is a form of pure rural tourism with characteristics of semi-full models. In terms of product characteristics, Rural tourism in Lamajang Village still has shortcomings, namely: inadequate provision of facilities to support rural tourism activities in the form of homestays and rural tourism information centers.
ESG Performance and Firm Value – Do Busy Directors Help?
Authors: Sabatini Sondang Zenita , A. Utama Cynthia
Published: January 2024

ESG is an important issue companies encounter when conducting business. The implementation of ESG with good performance will lead the company to be more prosperous and attractive to investors. This study examines how busy directors affect the increase in the value of companies that have good ESG performance within a sample of 41 public companies in Indonesia during the years 2017-2021. Data were obtained from Thomson Reuters and the companies’ annual reports. By using ESG score as a proxy for ESG performance variables and the percentage of busy directors’ presence in public companies, we can determine their influence on firm value. Panel data regression in e-views shows a positive and significant influence between ESG performance and firm value, and there is no significant effect between busy directors and firm value. Furthermore, we also find that the influence of busy directors as a moderator weakened the positive impact of ESG performance on firm value.
Priority setting for global WASH challenges in the age of wastewater-based epidemiological surveillance
Authors: Dorevitch Samuel , Shrestha Abhilasha
Published: January 2024

HIGHLIGHTS

Mortality due to inadequate WASH facilities exceeded that of COVID-19 in the regions of South-East Asia and Africa. The costs and benefits of wastewater-based surveillance are not known; however, the benefits of WASH interventions greatly exceed the costs. The dedication of effort and resources to wastewater-based surveillance and WASH in low- and middle-income countries should reflect disease burdens and cost/benefit assessments.
The Pharmacokinetic Interaction of Tirabrutinib with Voriconazole,
Itraconazole, and Fluconazole in SD Rats by UPLC-MS/MS
Authors: Xia Mengming , Liu Ya-Nan , Chen Jie , Xu Ren-Ai , Dai Gexin
Published: January 2024

Background:

Tirabrutinib is an orally effective, approved, and highly selective
second-generation Bruton's tyrosine kinase (BTK) inhibitor for the treatment of recurrent
or refractory primary central nervous system lymphoma (PCNSL).

Objective:

This study aimed to develop an ultra-high performance liquid chromatography-
tandem mass spectrometry (UPLC-MS/MS) method for the determination of tirabrutinib
concentration in rat plasma, where zanubrutinib was used as an internal standard
(IS). This method was also applied to study whether tirabrutinib would interact with voriconazole,
itraconazole, and fluconazole in rats, providing a reference value for clinical
medication guidance.

Methods:

In the current study, the organic solvent protein precipitation method was
used to treat plasma samples, which is simple and reproducible. Tirabrutinib (m/z 455.32
→ 320.21) and zanubrutinib (m/z 472.13 → 455.04) were separated on a Waters Acquity
BEH C18 column (2.1 × 50 mm, 1.7 μm) and detected by multiple reaction monitoring
(MRM) in positive ionization mode.

Results:

The method showed good linearity in the range of 5−3000 ng/mL for tirabrutinib
with the lower limit of quantification (LLOQ) of 5 ng/mL. The recovery and matrix
effects were 85.7-91.0% and 102.0-113.3%, respectively. The accuracy, precision, stability,
and carry-over effect were also acceptable. The method could also be used for determining
the pharmacokinetic interaction of tirabrutinib in rats. The results showed
AUC0→∞ of tirabrutinib to be increased by 139.3% and 83.9% in the presence of voriconazole
and fluconazole, respectively, while itraconazole had little effect.

Conclusion:

It is necessary to monitor the concentration of tirabrutinib in patients when
it is combined with voriconazole and fluconazole to achieve a better therapeutic effect
and reduce the risk of adverse reaction. Further research should be conducted in the future.
A Comprehensive Review on the State of the Art of Breast Cancers in
Italy
Authors: Iacopetta Domenico , Ceramella Jessica , Catalano Alessia , Rosano Camillo , Mariconda Annaluisa , Giuzio Federica , Bonofiglio Daniela , Saturnino Carmela , Longo Pasquale , Sinicropi Maria Stefania
Published: January 2024

Breast cancer (BC) currently represents one of the most prevalent cancers
among women worldwide and the leading cause of cancer death among women, also
negatively affecting the quality of life (QoL) in patients. Over the past two decades, BC
research has led to extraordinary advances in our understanding of the disease, resulting
in more effective treatments. However, its occurrence is still increasing. Several new
treatments are now under development worldwide, but they are not devoid of wellknown
side effects, and a great number of patients develop endocrine resistance. Nevertheless,
the design and synthesis of more suitable strategies and new drugs to treat breast
cancers, overcome resistance and side effects, and obtain better therapeutic outcomes
are needed. In this review, we summarize the therapies and the clinical studies currently
ongoing in Italy for the treatment of BCs, mainly HER2+ MBC, HER2-low MBC, and
TNBC, focusing on the most recent ones, also in consideration of diverse facets, including
some aspects related to QoL. Finally, some studies related to the usefulness of physical
activity in BC will be cited.
The Potential Association of TFR1/SLC11A2/GPX4 with Ferroptosis in Mediating Lipid Metabolism Disorders in Atherosclerosis
Authors: Cao Yuan , Song Nan , Wang Ying , Leng Xue , Wang Qun , Ma Yixin , Chen Si , Ju Xing , Jia Lianqun
Published: January 2024

Purpose:

Atherosclerosis is the most common and significant form of arterial disease,
characterized primarily by lipid accumulation and inflammatory cell infiltration as its main
pathological basis. This study aims to investigate the molecular mechanisms and associated
pathways by which iron accumulation may be involved in lipid metabolism abnormalities in atherosclerotic
mice.

Methods:

Relying on ApoE-/- mouse body position observation, blood biochemical analysis, oxidative
stress test and aortic tissue sectioning techniques, the effects of ferroptosis on lipid metabolism
in atherosclerotic mice were analyzed. Use RT-PCR analysis and transcriptomics tests
to understand the specific molecular mechanism.

Results:

Our analysis reveals a correlation between Ferroptosis and elevated levels of TC, TG,
ALT, AST, IL-1β, and TNF-α in the blood of atherosclerotic model mice. At the same time, it
exacerbates the pathological changes of mouse aorta tissue. Our results suggest a potential link
between ferroptosis and the dysregulation of TFR1/SLC11A2/GPX4 expression, along with the
presence of oxidative stress, in the progression of AS. Transcriptomics results indicate that ferroptosis-
mediated deterioration of atherosclerosis in ApoE-/- mice is potentially associated with
cell phagocytosis, apoptosis involving TNF-α, and the expression of atherosclerotic and other
process-related genes.

Conclusion:

Ferroptosis exacerbated the lipid metabolism disorder in atherosclerotic mice. The
core mechanism of its effect is that ferroptosis activates the TFR1/SLC11A2/GPX4 signaling
pathway, which leads to the up-regulation of oxidative stress in ApoE-/- mice, and ultimately aggravates
the abnormal lipid metabolism in ApoE-/- mice.
Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients
in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis
Authors: Cao Ning , Shou Zhangxuan , Xiao Yi , Liu Puqing
Published: January 2024

Background::

Astragali Radix (AR) has a long history as a traditional Chinese medicine
for anti-osteoporosis (OP) treatment. The aim of the study was to explore the effect and optimal
regimens of AR and its main ingredients (IAR) in OP treatment.

Methods::

Eligible animal studies were searched in seven databases (PubMed, Web of Science,
MEDLINE, SciELO Citation Index, Cochrane Library, China National Knowledge Infrastructure
and Wanfang). The primary outcomes were bone metabolic indices. The secondary outcome measure
was the anti-OP mechanism of IAR.

Results::

21 studies were enrolled in the study. The primary findings of the present article illustrated
that IAR could significantly increase the bone mineral density (BMD), bone volume over the total
volume, trabecular number, trabecular thickness, bone maximum load and serum calcium,
while trabecular separation and serum C-terminal telopeptide of type 1 collagen were remarkably
decreased (P < 0.05). In subgroup analysis, the BMD in the long treatment group (≥ 10 weeks)
showed better effect size than the short treatment group (< 10 weeks) (P < 0.05). Modeling methods
and animal sex were factors affecting serum alkaline phosphatase and osteocalcin levels.

Conclusion::

The findings suggest the possibility of developing IAR as a drug for the treatment of
OP. IAR with longer treatment time may achieve better effects regardless of animal strain and
age.
Nrf2 Inhibits GAPDH/Siah1 Axis to Reduce Inflammatory Reactions
and Proliferation of Microglia After Simulating Spinal Cord Injury
Authors: Sha Chunhe , Pan Feng , Wang Zhiqing , Liu Guohui , Wang Hua , Huang Tianwei , Huang Kai
Published: January 2024

Objective:

To explore the effect of nuclear factor erythroid 2-related factor 2
(Nrf 2) on microglial inflammatory response and proliferation after spinal cord injury
(SCI) through the glyceraldehyde phosphate dehydrogenase (GAPDH) / Seven in
absentia homolog 1 (Siah 1) signaling pathway.

Methods:

Human microglia HMC3 was induced by lipopolysaccharide (LPS) to
establish a SCI cell model. Microglia morphology after LPS stimulation was observed
by transmission electron microscope (TEM), and cellular Nrf2, GAPDH/Siah1 pathway
expression and cell viability were determined. Subsequently, the Nrf2 overexpression
plasmid was transfected into microglia to observe changes in cell viability and
GAPDH/Siah1 pathway expression.

Results:

Microglia, mostly amoeba-like, were found to have enlarged cell bodies after
LPS stimulation, with an increased number of cell branches, highly expressed Nrf2,
GAPDH and Siah1, and decreased cell viability (P<0.05). Up-regulating Nrf2 inhibited
the GAPDH/Siah1 axis, decreased inflammatory responses, and enhanced activity in
post-SCI microglia (P<0.05).

Conclusion:

Up-regulating Nrf2 expression can reverse the inflammatory reaction of
microglia after LPS stimulation and enhance their activity by inhibiting the GAPDH/
Siah1 axis.
Can Glycerol Carbonate be Synthesized Without a Catalyst?
Authors: Karmee Sanjib Kumar
Published: January 2024

Biodiesel and oleo-chemical industries have been producing huge quantities of glycerol as
a by-product. Value-added products can be synthesized from glycerol through different chemical and
enzymatic reactions, such as oxidation, carbonylation, reforming, acetalyzation, etherification, dehydration,
hydrogenolysis, hydrolysis, esterification, and transesterification. Glycerol is a low-cost polyol
that can be converted into glycerol carbonate, which has potential applications in polymer and biobased
non-isocyanate polyurethanes industries (Bio-NIPUs). The present contribution is the first of its
kind to report on the synthesis of glycerol carbonate via catalyst and solvent-free transesterification of
glycerol with dimethyl carbonate under conventional as well as microwave heating. Additionally, a
comparative study of conventional and microwave-assisted transesterification was performed. Under
conventional heating, 78% glycerol carbonate is obtained at 120oC in 36 hours, whereas, using microwaves,
92% of glycerol carbonate can be achieved in 30 minutes. Presently, biomass-based heterogeneous
materials are used in catalysis due to their importance within the context of sustainability. In
line with this, in this work, a series of green catalysts, namely, molecular sieves (MS, 4Å), Hβ-
Zeolite, Montmorillonite K-10 clay, activated carbon prepared from the shell of groundnut (Arachis
hypogaea), and biochar from sawdust pyrolysis were successfully employed. Glycerol carbonate was
thoroughly characterized by 1H and 13C NMR, FT-IR and MS. The method described here is facile
and green since the utilization of bioresource (glycerol) for the production of glycerol carbonate is
performed under microwave.
Pulmonary Arterial Hypertension (PAH) Group 1: Overview, Workup,
Risk Stratification, and Current (and Future) Treatment Approaches
Authors: Yaqoob Maidah , DeCato Thomas W. , Oudiz Ronald
Published: January 2024

Risk assessment (or risk stratification) and both current and future therapies for pulmonary
arterial hypertension (PAH) will be discussed in part B. Risk assessment is key in the initial
evaluation and follow-up of persons with PAH. Risk assessment provides information on disease
severity and mortality, which, over time, have been incorporated into the application of PAH therapies.
After the initial risk assessment, a 4-strata approach is recommended at subsequent follow-
up evaluations by the 2022 ERS/ESC pulmonary hypertension (PH) guidelines as described
initially in COMPERA 2.0. This method appears to have increased sensitivity to changes in risk
from baseline to follow-up and to changes in long-term mortality risk. Current PAH therapies target
the prostacyclin, endothelin, and nitric oxide pathways. A sequential approach to therapy has
been recommended since publication of the 2009 guidelines and, in the most recent iteration incorporates
the 4-strata approach at follow-up. Additional therapy is recommended when intermediate-
high or high-risk status is present. New therapies are under active investigation that include targeting
novel pathways. Sotatercept, a fusion protein that binds to and sequesters select transforming
growth factor β superfamily ligands, is the most promising novel therapy at this time. A recent
phase 3, randomized, double-blind, placebo-controlled study in group 1 PAH patients showed a
statistically significant improvement in 6-minute walk distance and additional studies of this drug
in PH populations are ongoing. Progress in phenotyping this heterogeneous disease is being made,
and as PAH therapies continue to evolve, the use of personalized treatment regimens may be possible
in the care of this complex, and highly morbid and mortal disease.
GFAP and UCHL1 in Non-traumatic SAH: The Story thus Far. A
Systematic Review of the Literature
Authors: Psochias Filippos , Mavrovounis Georgios , Stranjalis George , Kalamatianos Theodosis
Published: January 2024

Objective:

Non-traumatic subarachnoid hemorrhage (SAH) is associated with a high
percentage of misdiagnosis and poor prognosis. Biomarkers could be useful in the identification,
treatment/management guidance, and outcome improvement of SAH patients. The current systematic
review aims to investigate the potential role of biomarkers GFAP (Glial Fibrillary Acidic Protein)
and UCH-L1 (Ubiquitin C-Terminal Hydrolase L1) in the diagnosis and prognosis of non-traumatic
SAH.

Methods:

A systematic search of PubMed, Scopus, and Web of Science databases was conducted
from their inception through February 2023.

Results:

17 studies met the inclusion criteria and were included in this review. The vast majority of
the included studies (82%) were on GFAP. Most studies used blood and/or CSF samples and incorporated
multiple measurements through the initial hospitalization days. The majority of identified
studies reported significantly higher levels of GFAP and UCHL1 in SAH patients with poor outcomes.
There was notable variation in the specimen type and the timing of sampling.

Conclusion:

Quantification of GFAP and UCHL1 through the initial days of hospitalization shows
promise in the prediction of SAH patient outcomes. Further research is nevertheless warranted to
confirm these findings and further clarify the use of the two biomarkers in SAH diagnosis and the
prediction of severity and secondary events.
Analysis of Lanthanum Oxide Based Double-Gate SOI MOSFET using Monte-Carlo Process
Authors: Paramasivam Pattunnarajam , Gowthaman Naveenbalaji , Srivastava Viranjay M.
Published: January 2024

Introduction:

This work proposes a Double-Gate (DG) MOSFET with a Single Material
made of Silicon On-Insulator (SOI). The Lanthanum Oxide material with a high k-dielectric constant
has been used as an interface between two gates and the channel. The Monte Carlo analysis has been
used to determine the Conduction Band Energy (Ec) profiles and electron sheet carrier densities (ns)
for a Silicon channel thickness (tsi) of 10 nm at 0.5 V gate drain-source voltages. The transverse electric
fields are weak at the midchannel of DG SOI MOSFETs, where quantum effects are encountered.
The Monte Carlo simulation has been confirmed to be effective for high-energy transport. A particle
description reproduces the granularity property of the transport for nanoscale modeling.

Methods:

This work utilizes a Monte Carlo (MC) Simulation for the proposed Double Gate Single
Material Silicon On Insulator MOSFET with (La2O3=2 nm) as dielectric oxide on upper and lower
gate material. The electrical properties of the DG SOI MOSFETs with Lanthanum Oxide were analyzed
using Monte Carlo simulation, including the conduction band energy, electric field, potential
distribution, particle movement, and average velocity.

Results:

The peak electric field (E) simulation results and an average drift velocity (υavg) of 6Í105
V/cm and 1.6Í107 cm/s were obtained, respectively. The conduction band energy for the operating
region of the source has been observed to be 4% to the drain side, which obtained a value of -0.04 eV
at the terminal end.

Conclusion:

This proposed patent design, such as double-gate SOI-based devices, is the best suggestion
for significant scalability challenges. Emerging technologies reach the typical DG SOI
MOSFET's threshold performance when their geometrical dimensions are in the nanometer region.
This device based on nanomaterial compounds has been more submissive than conventional devices.
The nanomaterials usage in the design is more suitable for downscaling and reducing packaging density.
Valorization of Corn Steep Liquor for Improved Value-added
Products: A Review
Authors: Taiwo Abiola Ezekiel , Musonge Paul
Published: January 2024

Corn steep liquor (CSL) is a by-product of wet steeping corn and is a source of vitamins, minerals, and amino acids. Depending on how food processing firms dispose of waste,
CSL might have a negative impact on the environment. However, when CSL is used properly, it
can promote economic growth and sustainability and prevent adverse environmental effects.
However, the nutritional content of CSL and the high concentration of its organic matter suggest
it is a rich source of feedstock. It can be used as a nutrient supplement or precursor to other
products with even more value. CSL has been studied as a feedstock and additive for the sustainable production of chemicals and industrial products. A variety of bioproducts, including
ethanol, acetoin, vanillin, and a variety of other biofuels, can be made from CSL due to its low
cost and availability of components (nitrogen and carbon). The study seeks to highlight and present comprehensive novel uses of corn steep liquor in the circular economy to produce highervalued products with reduced carbon footprints.
Depression-reminiscent Behavior Induced by Chronic Unpredictable
Mild Stress Paradigm in Mice Substantially Abrogated by Diosmin
Authors: Sharma Abhishek , Dhingra Dinesh , Bhutani Rubina , Nayak Amit , Garg Adish
Published: January 2024

Background:

Diosmin has already been described and documented to be neuroprotective,
antioxidant and anti-inflammatory. It may possess or hold depressionalleviating
activity. Therefore, the purpose of the current research protocol is to investigate
the depression-relieving proficiency of diosmin in stressed and unstressed mice.

Methods:

Male mice (Swiss albino) were imperiled to an unpredictable chronic stress paradigm
every day for three sequential weeks, and depression-resembling behavioral despair
was induced. Imipramine 15 mg/kg and diosmin (25, 50 and 100 mg/kg) were dispensed
for 21 successive days to discrete groups of stressed and unstressed mice.

Results:

Both diosmin (100 mg/kg) and 15 mg/kg imipramine administration for 3 consecutive
weeks substantially or significantly diminished the immobility period of mice imperiled
to stress in comparison to stressed mice gauzed with the vehicle. Diosmin (25, 50 and
100 mg/kg) and imipramine considerably reinstated the diminished sucrose proclivity (sucrose
preference percentage; %) in stressed mice, demonstrating their considerable or substantial
depression-relieving effects. The locomotor activities of mice were not considerably
altered by these drugs. Antidepressant-like activity of diosmin for immobility periods
and preference for sucrose was observed to be analogous to imipramine. Diosmin (100
mg/kg) and imipramine substantially quashed CUMS- persuaded escalation of plasma corticosterone
and nitrite levels, malondialdehyde levels and MAO-A activity in the brain of
stressed mice. Both drugs also substantially reversed CUMS-prompted reduction in catalase
activity and brain glutathione levels.

Conclusion:

Accordingly, diosmin revealed significant anti-depressive activity in mice
imperiled to chronic mild unpredictable stress paradigm conceivably via mitigation of nitrosative
and oxidative stress, reticence of brain MAO-A action, and sink drop of plasma
corticosterone degrees.
Synthesis of Optimal Control of Spacecraft Angular Momentum for
Spatial Turn Taking into Account Energy Costs Using Quaternions
Authors: Levskii Mikhail
Published: January 2024

Background:

In this paper, we propose solving the specific original problem of control
synthesis of spacecraft attitude. Optimization of the control program is made with the use of
a new criterion of quality that combines energy costs and duration of reorientation under restrictions
on control (the presence of a time factor limits the duration of slew maneuver).

Methods:

The construction of optimal control for angular momentum change is based on the quaternion
method and L.S. Pontryagin maximum principle. An analytical solution to the problem
was obtained on the base of a differential equation relating the orientation quaternion and angular
momentum of a spacecraft.

Results:

Key properties of the optimal solution are formulated in analytical form; the features of
optimal motion are studied in detail. The control law is formulated in the form of explicit dependence
between control and phase variables. In a case when the controlling torque is limited by
the given restriction (at the beginning and end of a turn), analytical formulas have been written
for the duration of braking and acceleration. Main relations which determine optimal values of
parameters of the algorithm for control of angular momentum are given. Examples and results of
mathematical modeling of spacecraft motion formed by optimal control were given. This data in
addition to the theoretical descriptions illustrates the process of reorientation in evident form and
demonstrates the practical feasibility of a designed method for control of angular momentum during
spatial turn.

Conclusion:

The designed optimal algorithm of control of spacecraft motion improves the efficiency
of spacecraft attitude system, and originates more economical performance of spacecraft
during flight on orbit.
Explorando nuevas estrategias para la Gestión de Tecnología e Innovación en las Unidades Productoras Agrícolas de la Provincia de Cotopaxi
Authors: Garcia Marcelo Geovanny Monge , Juan Carlos Michalus , Maldonado Silvina , Vera Valdiviezo Nivaldo Apolonides
Published: January 2024

La Gestión de Tecnología e Innovación (GTI) juega un papel crucial en el avance del sector agropecuario de una nación, ya que promueve el mejoramiento de la productividad y competitividad en todas las regiones, consolidándose como una herramienta fundamental en su desarrollo. El propósito central de este estudio es proponer una nueva perspectiva en la gestión de la tecnología y la innovación para las Unidades de Producción Agropecuaria (UPA) de la provincia de Cotopaxi, presentando así una alternativa innovadora que busca resolver los retos existentes y futuros en esta materia. En el marco metodológico se utilizaron varias herramientas de análisis, entre ellas el análisis de componentes principales KMO, la correlación múltiple y el análisis de varianza ANOVA. Además, se realizaron entrevistas con actores clave, como el Ministerio de Agricultura y Ganadería, la Gobernación de Cotopaxi, los líderes campesinos indígenas de Cotopaxi y la Prefectura de Cotopaxi. Estas entrevistas permitieron recopilar información de gran relevancia para el estudio. Entre los principales resultados, se destaca la existencia de una estrecha relación entre diferentes elementos, como el Valor Agregado Bruto Agropecuario (VAB), el Em-pleo Agropecuario, la Pobreza Agraria Extrema, el Índice de Productividad Agropecuaria y la Innovación, en torno al desarrollo de las Unidades Productivas Agropecuarias de la provincia de Cotopaxi. Además, en las entrevistas se concluyó que los factores críticos para este desarrollo son los conocimientos ancestrales, la participación comunitaria, la transferencia tecnológica y la implementación del enfoque de cuádruple hélice. Asimismo, se pudo determinar que el entorno macroeconómico y sociocultural juega un papel en dicho desarrollo. En conclusión, el modelo de gestión de la tecnología y la innovación adopta un enfoque integral que considera conjuntamente los aspectos económicos, sociales y ambientales. Su implementación contribuirá significativamente al desarrollo y fortalecimiento de las Unidades Productivas Agropecuarias (UPA), impactando positivamente en el crecimiento local de la provincia de Cotopaxi. Palabras clave: Unidades de Producción Agropecuaria UPA.s, Gestión de Tecnología e Innovación GTI, Agrocultura, modelo.
Mapping the Cardiometabolic Patient Experience and Self-Care Behaviors to Inform Design, Implementation, and Persistent Use of Digital Health Care Solutions: Mixed Methods Study (Preprint)
Authors: Liska Jan , Mical Marie , Maillard Christophe , Dessapt Cécile , Bendig Europa , Mai Daniel , Piette John D , De Geest Sabina , Fontaine Guillaume
Published: January 2024

BACKGROUND

Cardiometabolic conditions including acute coronary syndrome (ACS) and type 2 diabetes (T2D) require comprehensive care and patient engagement in self-care behaviors, and the drivers of those behaviors at the individual and health system level are still poorly understood.

OBJECTIVE

We aim to gain insights into self-care behaviors of individuals with cardiometabolic conditions.

METHODS

A convenience sample of 98 adult patients with ACS and T2D was recruited in the United States, Germany, and Taiwan to participate in a mixed methods study using ethnographic methods. All participants completed 7-day web-based diaries tracking their level of engagement, and 48 completed 90-minute web-based semistructured interviews between February 4, 2021, and March 27, 2021, focusing on themes including moments of engagement. Qualitative analysis identified factors influencing self-care practices and a Patient Mind States Model prototype.

RESULTS

Patient reports indicate that many patients feel social pressure to adhere to treatment. Patients’ experience can be understood within 5 categories defined in terms of their degree of engagement and adherence (“ignoring,” “struggling,” “juggling,” “controlling,” and “reframing”).

CONCLUSIONS

For people living with ACS and T2D, the self-care journey is defined by patterns of patient experiences, which can identify areas that tailored digital health care interventions may play a meaningful role.
Privacy Concerns About Sharing General and Specific Health Information on Twitter: Quantitative Study (Preprint)
Authors: Esmaeilzadeh Pouyan
Published: January 2024

BACKGROUND

Twitter is a common platform for people to share opinions, discuss health-related topics, and engage in conversations with a wide audience. Twitter users frequently share health information related to chronic diseases, mental health, and general wellness topics. However, sharing health information on Twitter raises privacy concerns as it involves sharing personal and sensitive data on a web-based platform.

OBJECTIVE

This study aims to adopt an interactive approach and develop a model consisting of privacy concerns related to web-based vendors and web-based peers. The research model integrates the 4 dimensions of concern for information privacy that express concerns related to the practices of companies and the 4 dimensions of peer privacy concern that reflect concerns related to web-based interactions with peers. This study examined how this interaction may affect individuals’ information-sharing behavior on Twitter.

METHODS

Data were collected from 329 Twitter users in the United States using a web-based survey.

RESULTS

Results suggest that privacy concerns related to company practices might not significantly influence the sharing of general health information, such as details about hospitals and medications. However, privacy concerns related to companies and third parties can negatively shape the disclosure of specific health information, such as personal medical issues (β=−.43; P<.001). Findings show that peer-related privacy concerns significantly predict sharing patterns associated with general (β=−.38; P<.001) and specific health information (β=−.72; P<.001). In addition, results suggest that people may disclose more general health information than specific health information owing to peer-related privacy concerns (t165=4.72; P<.001). The model explains 41% of the variance in general health information disclosure and 67% in specific health information sharing on Twitter.

CONCLUSIONS

The results can contribute to privacy research and propose some practical implications. The findings provide insights for developers, policy makers, and health communication professionals about mitigating privacy concerns in web-based health information sharing. It particularly underlines the importance of addressing peer-related privacy concerns. The study underscores the need to build a secure and trustworthy web-based environment, emphasizing the significance of peer interactions and highlighting the need for improved regulations, clear data handling policies, and users’ control over their own data.
The Effects of the Processing of Positive Memories Technique on Posttrauma Affect and Cognitions Among Survivors of Trauma: Protocol for a Daily Diary Study (Preprint)
Authors: Greene Talya , Contractor Ateka A , Dicker-Oren Sheila Daniela , Fentem Andrea , Sznitman Sharon R
Published: January 2024

BACKGROUND

The Processing of Positive Memories Technique (PPMT) is a promising new treatment approach for posttraumatic stress disorder (PTSD), which involves detailed narration and processing of specific positive autobiographical memories. Indeed, preliminary case-series studies have found reductions in PTSD symptoms, negative affect, and negative cognitions among survivors of trauma who have received PPMT. However, PPMT’s effects have not been investigated at the daily level. In this study, we describe the protocol for a study that will examine the daily-level impacts of PPMT in a trauma-exposed, nonclinical community sample.

OBJECTIVE

This study uses an innovative research protocol that combines case-series design and daily diary approaches to examine changes in daily affect, daily cognitions, and daily PTSD symptoms pre- and post-PPMT. We hypothesize that at the daily level, in comparison to their own pre-PPMT levels, following the PPMT intervention, participants will report (1) a lower count of endorsed daily PTSD symptoms, (2) increases in daily positive affect and decreases in daily negative affect, (3) increases in positive affect reactivity to daily positive events, and (4) decreases in daily posttrauma cognitions.

METHODS

We are currently recruiting participants (target n=70) from a metroplex in the southwest United States. Following a screening survey, eligible participants complete a preintervention baseline survey, followed by 21 daily surveys in their natural environments. Then, they receive 4 PPMT sessions on a weekly basis. After the conclusion of the PPMT intervention, participants complete a postintervention outcome survey and 21 daily surveys. To compare daily affect, daily cognitions, and daily PTSD symptoms before and after PPMT, we will use the daily diary report data and conduct multilevel random intercepts and slopes linear regression models.

RESULTS

Data collection was initiated in March 2022 and is expected to end by June 2024. As of November 28, 2023, a total of 515 participants had consented to the study in the screening phase. No analyses will be conducted until data collection has been completed.

CONCLUSIONS

Study findings could clarify whether deficits in positive autobiographical memory processes may also characterize PTSD alongside deficits in traumatic memory processes. Furthermore, PPMT could be an additional therapeutic tool for clinicians to help clients reduce posttraumatic distress in their everyday lives.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/51838
Feasibility of live online group stress management training relative to individual, guided web-based training for employees – a randomized pilot study (Preprint)
Authors: Boß Leif , Hannibal Sandy Carolin , Lehr Dirk
Published: January 2024

BACKGROUND

In recent decades, digital stress management training, typically using the internet to reach targeted individuals, has gained increasing attention in occupational health promotion. Evidence for Internet-based training delivered in group formats is scarce, however, despite its broad implementation for traditional non-digital health promotion.

OBJECTIVE

This study’s aim was to explore the feasibility of live, online stress management training delivered in a group format and compare it to Internet-based training targeting individuals.

METHODS

Employees (N=62), recruited from an open access website, were randomized into either group or individual training. Group training consisted of seven weekly online appointments led by a trainer and conducted via videoconference. Individual training consisted of seven web-based sessions which included written feedback provided by an e-coach after each session. The primary outcome was perceived stress eight weeks after training initiation. Feasibility was analyzed in terms of participants’ satisfaction, adherence, and perceived benefits of both training formats, assessed via both written questionnaires and interviews.

RESULTS

Participants in group training [Cohen’s d = 0.9 (95% confidence interval: 0.4 to 1.5)] and individual training [1.3 (0.6 to 2.0)] both experienced statistically-significant reductions in stress, with no significant difference between the two training formats [0.25 (-0.32 to 0.83); p = .579)]. Full adherence rates were 70% in the group training and 50% in the individual training. Participants were satisfied with both formats, appreciating the social support and personal contact of the group setting, while appreciating the time flexibility and personal contact with an e-coach offered through individual training.

CONCLUSIONS

This pilot study showed promising effects for the acceptance and health-related effectiveness of stress management training delivered in a group setting via videoconference. The findings highlight the value of personal contact with a coach and peers for positive user experiences during digital stress management interventions.

CLINICALTRIAL

German Clinical Trials Register (DRKS00024965)
Assessment of ChatGPT-4 in Family Medicine Board Examinations: An Observational Study Using Advanced AI Learning and Analytical Methods (Preprint)
Authors: Goodings Anthony , Kajitani Sten , Chhor Allison Dana , Albakri Ahmad , Pastrak Mila , Kodancha Megha , Ives Rowen , Lee Yoo Bin , Kajitani Kari
Published: January 2024

BACKGROUND

This research explores the capabilities of ChatGPT-4 in passing the American Board of Family Medicine (ABFM) Certification Examination. Addressing a gap in existing literature, where earlier Artificial Intelligence (AI) models showed limitations in medical board exams, this study evaluates the enhanced features and potential of ChatGPT-4, especially in document analysis and information synthesis.

OBJECTIVE

The primary goal is to assess whether ChatGPT-4, when provided with extensive preparation resources and using sophisticated data analysis, can achieve a score equal to or above the passing threshold for the Family Medicine Board Examinations.

METHODS

In this study, ChatGPT-4 was embedded in a specialized subenvironment, "AI Family Medicine Board Exam Taker," designed to closely mimic the conditions of the ABFM Certification Examination. This subenvironment enabled the AI to access and analyze a range of relevant study materials, including a primary medical textbook and supplementary online resources. The AI was presented with a series of past ABFM exam questions, reflecting the breadth and complexity typical of the exam. Emphasis was placed on assessing the AI's ability to interpret and respond to these questions accurately, leveraging its advanced data processing and analysis capabilities within this controlled subenvironment.

RESULTS

In our study, ChatGPT-4's performance was quantitatively assessed on 300 practice ABFM exam questions. The AI achieved a correct response rate of 88.67% (95% CI: 85.08% to 92.25%) for the Custom Robot version and 87.33% (95% CI: 83.57% to 91.10%) for the Regular version. Statistical analysis, including the McNemar test (P-Value: 0.4533), indicated no significant difference in accuracy between the two versions. Additionally, the Chi-square test for error type distribution (P-Value: 0.3163) revealed no significant variation in the pattern of errors across versions. These results highlight ChatGPT-4's capacity for high-level performance and consistency in responding to complex medical examination questions under controlled conditions.

CONCLUSIONS

The study demonstrates that ChatGPT-4, particularly when equipped with specialized preparation and operating in a tailored subenvironment, shows promising potential in handling the intricacies of medical board examinations. While its performance is comparable to the expected standards for passing the ABFM Certification Examination, further enhancements in AI technology and tailored training methods could push these capabilities to new heights. This exploration opens avenues for integrating AI tools like ChatGPT-4 in medical education and assessment, emphasizing the importance of continuous advancement and specialized training in AI applications in healthcare.
Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy: A Randomized Controlled Trial
Authors: Barratt Jonathan , Liew Adrian , Yeo See Cheng , Fernström Anders , Barbour Sean J. , Sperati C. John , Villanueva Russell , Wu Ming-Ju , Wang Dazhe , Borodovsky Anna , Badri Prajakta , Yureneva Elena , Bhan Ishir , Cattran Daniel ,   on behalf of the Cemdisiran Phase 2 Study Investigators and Collaborators
Published: January 2024

Background

IgA nephropathy is the most common primary GN. Clinical features of IgA nephropathy include proteinuria, which is the strongest known surrogate of progression to kidney failure. Complement pathway activation is a critical driver of inflammation and tissue injury in IgA nephropathy. Cemdisiran is an investigational RNA interference therapeutic that suppresses hepatic production of complement component 5 (C5), thereby potentially reducing proteinuria in IgA nephropathy. We evaluated the efficacy and safety of cemdisiran in adult patients with IgA nephropathy at high risk of kidney disease progression.

Methods

In this phase 2, 36-week, double-blind study, adult patients with IgA nephropathy and urine protein ≥1 g/24 hours were randomized (2:1) to subcutaneous cemdisiran 600 mg or placebo every 4 weeks in combination with the standard of care. The primary end point was percentage change from baseline at week 32 in urine protein-to-creatinine ratio (UPCR) measured by 24-hour urine collection. Additional end points included change from baseline in UPCR measured by spot urine, serum C5 level, and safety assessments.

Results

Thirty-one patients were randomized (cemdisiran, N=22; placebo, N=9). Cemdisiran-treated patients had a placebo-adjusted geometric mean change in 24-hour UPCR of –37.4% (cemdisiran-adjusted geometric mean ratio to baseline [SEM], 0.69 [0.10]) at week 32. Spot UPCR was consistent with 24-hour UPCR placebo-adjusted change of –45.8% (cemdisiran-adjusted geometric mean ratio to baseline [SEM], 0.73 [0.11]). Mean (SD) change in serum C5 level from baseline at week 32 was –98.7% (1.2) with cemdisiran and 25.2% (57.7) with placebo. Over 36 weeks, most adverse events were mild or moderate and transient; the most common adverse event after cemdisiran treatment was injection-site reaction (41%).

Conclusions

These findings indicate that treatment with cemdisiran resulted in a reduction of proteinuria at week 32 and was well tolerated.
DDOS Attacks Detection via Deep Learning Approaches
Authors: Priyanka Ms. V. Rose
Published: January 2024

Abstract: The proliferation of Distributed Denial of Service (DDoS) attacks presents a pressing challenge to network security. Conventional rule-based detection methods are increasingly inadequate against the evolving tactics employed by cyber adversaries. This journal proposes a novel approach integrating Support Vector Machines (SVM) into advanced machine learning architectures for fortified DDoS detection. The research methodology initiates with comprehensive data collection, gathering diverse network traffic scenarios and DDoS attack instances. This dataset becomes the foundation for subsequent phases, employing sophisticated feature engineering to extract vital patterns for model development. The feature selection process involves using feature engineering techniques including Data Collection, Model Development and SVM Integration, to extract the most discriminative and relevant features from the network traffic data. The primary innovation lies in the creation of a hybrid CNN-LSTM model, capable of discerning spatial and temporal dependencies within network data, thereby augmenting DDoS threat identification. The integration of SVM into machine learning and deep learning paradigms forms the crux of this study. By leveraging SVM's classification proficiency alongside the CNN-LSTM model's capabilities, a sophisticated DDoS detection system aims to surpass conventional rule-based limitations.
Homoeopathy in Cervical Cancer
Authors: Tripathy Dr. Tridibesh , Das Shankar , Dwivedi Rakesh , Gautam Mohini , Tripathy Sanskriti
Published: January 2024

Population growth is related to high fertility rates, thus grading multiparous women in the risk zone of cervical cancer.Cervical cancer is a chronic phenomenon of cervical erosion. Following that the body goes through is the Human Papilloma Virusinfection, which becomes the main reason for cervical cancer. The review article deals with the status of cervical cancer at theglobal level, followed by the situation in India. Further, the article discusses the role and status of HPV vaccines globally andnationally. The role of homeopathy of the Ministry of AYUSH of India in cervical cancer is discussed in the later section of thearticle. Here, it is proposed that a multi-stage treatment protocol based on therapeutics in homoeopathic materia medica will bean effective tool. The article's focus on homeopathy as the therapeutic system which can cover masses through its properties likecost effectiveness, therapeutic effectiveness, and less side effects.
Strategic Project Management of the Socio-Ecological Development of the Arctic Zone of the Russian Federation
Authors: Zaretsky A. A. , Kozyrev A. A.
Published: January 2024

The article analyzes the processes of project management in the implementation of social and environmental programs in the Arctic zone of the Russian Federation. Current regulatory and legal acts aimed at ensuring the development of the Arctic zone are considered. The problems of rational environmental management, development of territories with minimal negative impact on the state of the environment and taking into account the environmental situation in the region is identified. State programs for support and assistance to people living and working in the regions of the Arctic zone of the Russian Federation, aimed at economic support, development of a personnel reserve and health preservation, and environmental projects, are analyzed and presented. The priority importance of social and environmental projects to develop infrastructure, improve the quality of life of the population and preserve the primary ecosystem is noted. The use of methods for calculating environmental safety indices and urban environment quality indices of the Ministry of Construction of the Russian Federation when ranking the subjects of the Arctic zone made it possible to identify the most problematic areas in ensuring the quality of life, and, accordingly, priority areas for the development and implementation of strategic projects. The importance of strategic programs and projects to reduce the level of pollutants, to increase the population’s supply of high-quality drinking water in cities and to improve the quality of the urban environment is emphasized to improve the quality of life of residents of the cities of the Arctic region.
Strategic Planning Documents Assessment of the Russian Far East
Authors: Borshchevskiy G. A.
Published: January 2024

In the article we analyze strategic planning documents on the Russian Far East socio-economic development. The study is based on a   combination of quantitative methods (e.  g. regression and correlation analysis, modeling, average method, index method, difference of differences method, factor analysis) and qualitative methods (document analysis, case study, best practice identification, classification method, SWOT analysis). We proposed an index of socio-economic development and revealed that the activation of the regulation have a   multiplier effect in a   generally positive impact on the Far Eastern regions development. Forecasting showed that in the medium term, the scenario of moderate growth can be considered the most likely. We developed some proposals to improve the strategic planning documents efficiency. In particular, “point” tools should be integrated to ensure a   complex planning. Each planning document should provide for the possibility of statistical evaluation. It is necessary to justify the introduction of new strategic priorities, and monitoring should be carried out not only during the implementation of the document (in actu ), but also after its completion ( ex post).