bluuebunny/crossref_metadata_2025 huggingface dataset:
Tinjauan Perkembangan dan Pertumbuhan Perbankan Syariah di Indonesia
Authors: dedisuhendro
Published: January 2019

The largest population of Islam in the world is an Indonesian country where the amouth of Muslim population reaches 204 million inhabitants. The amouth of Islam that is classified as many in Indonesia, has a potential to trigger the development and growth of sharia banks. Government's attention and support for sharia banking is strengthened by the policy with the issuance of sharia banking law. PT Bank Mualat Indonesia is the first syariah bank in Indonesia which was established and operated in 1992 then followed by other sharia bank. PT Bank Muamalat Indonesia was born from the work of the banking team of the Majelis Ulama Indonesia (MUI), which on November 1, 1991 signed the deed of establishment of PT Bank Muamalat Indonesia, collected the purchase of shares of Rp.84 billion. The established sharia bank is a financial services banking institution operating on the basis of Islamic ethics and value systems, especially those free of interest (riba), free from speculative non-productive activities such as gambling (maysir), free from unclear and dubious matters (gharar), based on justice principles, and only finance halal business activities. The institutionalsector from 2007 to 2017 when viewed from the BUS (Islamic Commercial Bank) has increased although the increase is not too high, while the USS (Islamic Business Unit of a Conventional Bank) has fluctuated, the a mouth of BPRS (Islamic Rural Bank) has increased very well, growth the a mouth of sharia banking office network also fluctuated. The development and growth of total assets, DPK (Depositor Funds), and the amount of PYD (Financing) has always increased from 2007 to 2017. So that Islamic banks become a good banking model and is ideal in advancing the nation's economy
Workers’ task choice heuristics as a source of emergent structure in digital microwork
Authors: Kässi Otto , Lehdonvirta Vili , Dalle Jean-Michel
Published: January 2019

Digital labor markets are structured around tasks and not around fixed- or long-term employment contracts. We study the consequences of the granularization of work for digital micro workers. To address this question, we combine interview data from active online micro workers and online data on open projects scraped from Amazon's Mechanical Turk platform to study how the digital micro workers choose which tasks they work on. We find evidence for preferential attachment: workers prefer to attach themselves to experienced employers who are known to offer high quality projects. In addition, workers also clearly prefer long series of repeatable tasks over one-off tasks, even when one-off tasks pay considerably more. We thus see a re-emergence of certain types of organizational structure.
Enhancing and accelerating social science via automation: Challenges and opportunities
Authors: Yarkoni Tal , Eckles Dean , Heathers James , Levenstein Margaret , Smaldino Paul E. , Lane Julia I.
Published: January 2019

Automation plays an increasingly important role in science, but the social sciences have been comparatively slow to take advantage of emerging technologies and methods. In this review, we argue that greater investment in automation would be one of the most effective and cost-effective ways to boost the reliability, validity, and utility of social science research. We identify five core areas ripe for potentially transformative investment, including (1) machine-readable standards, (2) data access platforms, (3) search and discoverability, (4) claim validation, and (5) insight generation. In each case, we review limitations associated with current practices, identify concrete opportunities for improvement via automation, and discuss near-term barriers to progress. We conclude with a discussion of practical and ethical considerations researchers will need to keep in mind when working to enhance and accelerate social science progress via automation.
Diffusion of KM Education in LIS Schools
Authors: Katuščáková Marcela , Jasečková Galina
Published: January 2019

This paper aims to identify the current state of knowledge management (KM) diffusion in LIS schools. In terms of content, we have identified two principal approaches to the perception of KM in the LIS community: an active approach, seeing KM as an opportunity for the LIS community to change; and a passive approach, seeing KM merely as a topic of information management with a new label. Our research analyzed study programs at 145 LIS schools and in 188 LIS study programs in the United States, Canada, Europe (in particular, Russia), Australia, India, South Africa, China, Japan, Singapore, and Brazil and observed the inclusion or non-inclusion of KM courses in those programs. We employ a narrower approach to defining a KM course as being one having the term “knowledge management” in its name. The findings indicate that KM courses are integrated in one-third of the LIS study programs analyzed, and in schools with an information science focus this figure can rise to around 45%. Given the importance of this area and various views regarding KM diffusion in LIS schools, we recommend that those who have already implemented a KM course in their LIS programs create an informal community of practice (CoP) on KM implementation in LIS schools and build an open database of lessons learned from such integration, thereby capturing and sharing this crucial knowledge in a single place.
Health Informatics Educational Offerings through ALA-Accredited LIS Programs
Authors: Raszewski Rebecca , Dwyer Jamie , Griffin Tina
Published: January 2019

Librarians who pursue a health sciences librarianship career may need an understanding of health informatics for their work with health-care professionals. Health sciences librarianship courses and degrees are available in most American Library Association (ALA)-accredited library and information science (LIS) programs, but health informatics educational offerings within LIS programs have not been previously examined in the LIS literature. ALA-accredited programs’ websites were examined to determine the availability of health sciences librarianship and health informatics educational offerings (e.g., courses, degrees) because ALA accreditation is a globally recognized accreditation standard. The institutions’ Carnegie Classifications and their programs’ iSchools statuses were also included in the analysis for benchmarking purposes. LIS programs may use the data from this study for benchmarking against other programs to compare their programs to peers, if there are gaps in their educational offerings, or to examine opportunities for expanding their current health informatics educational offerings and meet professional competencies.
The investigation of the relationship between biofilm-forming properties of clinical strains of p.aeruginosa and their sensitivity to antiseptic medicines
Authors: Nazarchuk O.A. , Faustova M.O. , Bobyr V.V. , Kordon Yu.V.
Published: January 2019

High antimicrobial properties of antiseptics determine the scientific interest in the study of their effect on the biofilm formation of clinically significant pathogens and the detection of a probable dependence between the sensitivity of bacteria to them and the ability to form biofilms. The aim — was to study the biofilm-forming properties of clinical strains of P.aeruginosa, depending on their sensitivity to various antiseptic medicines. 30 clinical strains of P.aeruginosa were isolated and identified from the patients with infectious complications of different areas who had been treated at the burn, intensive care and surgical units. The study of biofilm-forming properties of clinical isolates of P.aeruginosa was performed by using the spectrophotometric technique by G.D. Christensen (MtP microtiter plate test). The sensitivity assessment of the derived strains to antiseptics (decametoxine, decasan, miramistin, chlorhexidine) was done by double serial dilutions according to the standard procedure approved by the Order №167 of the Ministry of Public Health of Ukraine. The statistical processing of the results obtained was carried out by “Microsoft Excel 2010” software package. In order to determine the relationship between the biofilm formation and sensitivity to antiseptic medicines of P. aeruginosa strains, we determined the correlation coefficient (r-Pearson coefficient). The clinical strains of P.aeruginosa were found to be the most sensitive to decasan and miramistin, and their MICs did not differ 70,31±25,98 mg/ml and 68,5±33,20 mg/ml respectively. Chlorhexidine has been shown a reducing of antimicrobial efficiency against P.aeruginosa (MIC 115,62±59,75 μg/ml). High biofilm-forming properties of clinical isolates P.aeruginosa have been proved. The optical density of the biofilms formed by these microorganisms was 0,674±0,17 density units for 24 hours of cultivation. A direct correlation between the sensitivity of strains P.aeruginosa to decamethoxine, decasan, miramistin and their biofilm-forming properties was established. The sensitivity of the clinical strains to chlorhexidine did not depend on their biofilm potential. Clinical strains of P.aeruginosa have high biofilm-forming properties and retain sensitivity to antiseptic medicines based on cationic surfactant antiseptics. Decamethoxine and miramistin provide the highest antimicrobial action on P.aeruginosa isolates. The sensitivity of P.aeruginosa to decamethoxine, decasan, miramistin has shown to be in a direct correlation with their biofilm-forming properties.
The activity of hemostatic and oxidative-reduction systems according to different classes of ulcer bleeding
Authors: Dutka І.I. , Grynchuk F.V.
Published: January 2019

Haemostatic therapy of ulcer bleeding (UB) is based on activation of the coagulation system and depression of the fibrinolytic one. Though not so much attention is paid to the oxidation-reduction system. Aim of the study — To elaborate the recommendations on optimization of hemostatic therapy. Were examined 25 patients with UB. 4 patients were evaluated by Forrest classification, type ІВ, 5 – type ІІА, 6 — type ІІВ, and 10 — type ІІІС. Patients with type ІВ had endoscopic haemostasis procedures. All patients got a standard haemostatic complex. Two patients who were evaluated by Forrest classification type ІІА had bleeding recurrence. The following data was determined in blood plasma: fibrinolytic and proteolytic activity, fibrinase, antithrombin ІІІ, prothrombin index, isolated double bonds, diene conjugates, cetodienes and conjugated trienes, oxidation of neutral and alkaline proteins, malonic aldehyde, renew glutathione, catalase. Patients who were evaluated by Forrest classification type ІІА had both a disorder of redox system and hemostasis system balance, caused by a violation of synthesis of its factors. This contributes to the occurrence of bleeding recurrence. The results of redox system together with the criteria for hemostasis condition can be used to predict the recurrence of ulcer bleeding. Medicinal measures need to be adjusted, and antioxidants together with hepatoprotectors to be prescribed. So, patients with UB recurrence have an excessive activation of lipoperoxidation, low level of basic proteins, decrease in functional capacity of antioxidant mechanisms and hemostasis system imbalance, caused by a violation of synthesis of its factors, it is essential to take into account while predicting UB recurrence, and in case of UB one should add to the medication management those means that inhibit the activity of lipid oxidation and contribute to the restoration of synthesis processes of hemostasis factors. The prospect of further development is the assessment of the effectiveness of an optimized treatment complex.
Results of cytochemical investigation of neutrophil granulocytes in patients with purulent-inflammatory diseases of fine tissues on the type 2 diabetes mellitus
Authors: Zheliba M.D. , Bohachuk M.H.
Published: January 2019

Patients with purulent-inflammatory diseases of soft tissues on the background of diabetes type 2 are resistant changes in various parts of the immune system. Hyperglycemia, hyperlipidemia, insulin resistance and adaptive hyperinsulinemia affect the cells of the immune system, promote the development of metabolic immunosuppression with the formation of stable immune dysfunction. The purpose of the study to investigate and analyze the metabolic state of immunocompetent cells in patients with purulent-inflammatory diseases of soft tissues on the background of DMD type 2. The study was conducted in 47 patients (the main group) with purulent-inflammatory diseases of soft-tissue on the background of diabetes mellitus, and 20 healthy volunteers (the comparison group) using the cytohistochemical restoration method of NST based on the percentage composition of neutrophils that have cytoplasm of formazan granules. The spontaneous neutrophil response was studied, as well as the parameters of the NST-test in stimulation of neutrophil granulocytes in vitro to assess the bactericidal, resource potential and their ability to complete phagocytosis. Results of the study showed that the decrease in the activity of myeloperoxidase and the NST-test in the conditions of stimulation of neutrophil granulocytes is a sign of unsatisfactory state of the bactericidal system of cells, which may be the cause of acute inflammatory processes in the body that accompany type 2 diabetes, which leads to functional exhaustion of the macrophage level of the immune body protection. At GZZMT against the background of DM 2 type compared with the norm, the “spontaneous” NST-test of neutrophils is high, which is due to the presence of inflammatory process. The index of stimulation of neutrophils is lower in the main group (1.6 times: 5.3±0.2% in the main group versus 8.4±0.4% in the control, p≤0.05), which is an indicator of a relatively weaker stimulation of those populations of neutrophils that were responsible for high indices in the “spontaneous” NST test, and the impaired state of cellular metabolism. So, in patients with type 2 diabetes, a violation of the bactericidal system of organism protection, which is one of the causes of the development of infectious and inflammatory processes.
Application of endovideosurgery in the treatment of ventral hernias after gunshot wounds of the abdomen
Authors: Kashtalian M.A. , Herasymenko O. S. , Yenin R.V. , Kvasnevskiy A.A.
Published: January 2019

Gunshot wounds of the abdomen are often accompanied by a significant destruction of the abdominal cavity with the development of peritonitis, and in the future — various complications (failure of anastomoses, abscess formation, repeated bleeding, etc.), which requires repeated surgical interventions, and as a consequence — the formation of postoperative ventral hernias. The aim of the study is to improve the results of surgical treatment of ventral hernias after gunshot wounds of the abdomen due to the use of laparoscopic techniques. The analysis of treatment of 21 patients with postoperative ventral hernias formed as a result of operations concerning gunshot wounds of the abdomen was carried out. 14 wounded suffered one operation on the abdominal organs in the past (66.7%), 5 — two operations (23.8%), 1 — three operations (4.8%), 1 — five operations (4.8%). The dimensions of the hernial gates and the risk of recurrence were determined according to the SWE classification: W1 — 9 patients (42.9%), W2 — 8 (38.1%), W3 — (9.5%), W4 — 2 (9.5% ). The third patients underwent laparoscopic allogernioplasty according to the IROM technique with a Teflon allograft, which was fixed in 2 cases with the help of a herniostepler, in the 1st — with transdermal separate seams with Teflon filament. Complications after laparoscopic operations were not. The use of laparoscopic techniques can significantly reduce bed-day, avoid the development of abdominal compartment syndrome, previously to activate the patient. Laparoscopic allogernioplasty according to the method of IPOM by the Teflon graft is considered to be the operation of choice.
Ponad czasem - w duszy człowieka
Authors: Gracla Jadwiga
Published: January 2019

This article presents one of the newest Polish issue: Bedbug by Mayakovsky. Author draws attention to the universal values of art: the longing for happiness and closeness. Polish spectacle moves the action the second part of the drama to contemporary, and only partially retains universal values. It has for a strong political overtones.
Поэтическая антроподицея Леонида Мартынова
Authors: Rybalczenko Tatiana
Published: January 2019

The article reveals the picture of the world in poetry L. Martynov, to identify the concept of man as a demiurge-generation of evolution of space development as a tool of self-nature. The article accented the originality of the poetic philosophy and its proximity leading natural-philosophical and cultural concepts in the philosophy of the twentieth century: а noosphere idea in the philosophy of Russian cosmists, a sinergetics development model and the ecophilosophy the second half of the twentieth century. It installed here stability and correction of natural philosophy and anthropology of Martynov in his poetry from the 1920s to the 1970s.
Средняя температура по больнице, czyli o pewnym typie skrzydlatych słów w kontekście leksykograficzno-translatorycznym
Authors: Gasek Bogumił
Published: January 2019

Present article is an analysis of winged words Sredniaia temperatura po bol’nice with the indication to popular anecdotes that in many cases are a source for such expressions and warrants attention and consideration of lexicographers and translators.
Tłumacz wobec przekazu wspomnieniowego (na materiale Dziennika warszawskiego Zinaidy Gippius w tłumaczeniu Henryka Chłystowskiego)
Authors: Perużyńska Kinga
Published: January 2019

The aim of the article is to present The Warsaw Diary by Zinaida Gippius, published in 1969 and translated into Polish by Henryk Chłystowski (2010). Based on the analysis of Russian and Polish versions of the book, it can be concluded that Chłystowski retains in his translation four dimensions of the diary as a historical document: facts, opinions, author’s personal feelings and her subjective mentality.
O potrzebie „zarządzania” imionami własnymi w przekładach powieści kryminalnych Aleksandry Marininy
Authors: Orzechowska Joanna
Published: January 2019

In order to encourage the minimal reader to reach for Russian literature, one needs to present elements of the foreign reality in such a way that would encourage them to get to know alien phenomena and extend their cognitive base, rather than discouraging them with complexity and strangeness. One of the elements which are rooted in culture and which require proper management in translation are proper names. In translation from Russian into Polish it is worth focusing on managing hypocorisms (diminutives), colloquial forms of vocative and patronymics.
Sposoby identyfikacji osób w księgach metrykalnych parafii prawosławnych na Kujawach wschodnich i ziemi dobrzyńskiej na przełomie XIX i XX wieku
Authors: Duszyński-Karabasz Henryk
Published: January 2019

The article is devoted to the methods of nominal configuration in the Parish registry books form East Cuyavia and the Dobrzyn Land in the Late 19th and Early 20th Centuries (Aleksandrów Kujawski, Włocławek, Lipno, Rypin). There are several types of identifying elements in the registry books: first name, patronymic, last name, profession, function, social estate, place of origin or residence, religion, affiliation which are the components of the identifying formulas. They are discussed in the article and also the examples are mentioned.
Polski Wykop, czyli Wschód Andrzeja Stasiuka
Authors: Sienkiewicz Martyna
Published: January 2019

The aim of this paper is to compare and discuss, direct and indirect, intertextual references to Andrzej Platonov’s The Foundation Pit in The East of Andrzej Stasiuk. A. Stasiuk’s novel is an attempt of self-discovery, finding own roots, seeing „clarity of existence”. Autobiographical narrator of the novel often refers to fragments of The Foundation Pit by A. Platonov, which he finds in the past of his grandparents, his parents and his own. Characters in both novels try to find the same sense, hidden truth, despite time and geographical gap dividing them. Traveller from The East, communism child, recalls resettlement and Jewish extermination, in other words about matter annihilation. Image of Poles, Russians, Chinese people and communism creates integral whole and forces to reflect over past, present and future times. Whereas the East, which according to narrator, begins at the east bank of Vistula and reaches to China, becomes a foundation pit, where through fire and destruction, foundations of communism were built.
Twórczość pisarzy pierwszej fali emigracji rosyjskiej w przekładach Juliana Tuwima
Authors: NDiaye Iwona Anna
Published: January 2019

The author pays attention to the Polish-Russian literary contacts after 1917. The subject of critical analysis is the translation heritage of Y. Tuvim – polish poet, writer and translator, participant of the literary club “Little Lodge in Kolomna”, founded in Warsaw by D. Filosofov. Y. Tuwim is better known as the translator of A. Pushkin, V. Mayakovsky by todays readers However, in his rich heritagethere are also works of Russian emigrants: L. Gomolitsky, N. Evreinov, V. Khodasevich.
Multimedialny słownik lingworealioznawczy – nowe narzędzie w lingwokulturologii stosowanej
Authors: Olechno-Wasiluk Joanna
Published: January 2019

The paper constitutes an attempt to delineate the main assumptions, aims and research subject of applied linguo-cultural studies. This discipline works on the border of theoretical linguocultural studies and methodology of teaching a foreign language. The paper presents Multimedia Linguo-cultural Dictionary available on the webpage of Pushkin State Russian Language Institute. The author analyses the macro- and microstructure of the dictionary, focusing on its innovativeness. Entries in the dictionary are described in their entirety, considering references to the real world, which are essential in the socio-cultural functioning of every language, its description and teaching. This helps realise the main assumptions and aims of applied linguo-cultural studies.
Этнолингвистические и типологические параллели в фольклорном творчестве народов (на материале свадебно-обрядовых песен башкир)
Authors: Султангареева Розалия
Published: January 2019

In Turkic (Bashkir) wedding folklore, in the heritage of world spiritual culture, centuries-old knowledge of philosophy, life-concepts and ideals, as well as language, etiquette, moral and moral values of peoples are concentrated. This article covers the wedding and ritual culture of the Turks and Slavs. Using Bashkir ritual as an example, typological features and parallels in folklore genres associated with common situations of marriage festivals, clan interests and emotions are revealed. Wedding genres of lamentations, good wishes and praise, whose origins go back to the magic of kind words, tears and crying after a complex transformation, create a picture of universal ritual codes.
Аповесць Янкі Брыля Сірочы хлеб y польскім кантэксце: Баляслаў Прус, Стэфан Жэромскі
Authors: Alsztyniuk Anna
Published: January 2019

This article focuses on the relationship between Yanka Bryl and Poland, showing the influence of Polish classics on his literary legacy. Stories such as Orphan’s Bread by Yanka Bryl, Orphan’s Plight by Bolesław Prus and the novel Sisyphean Labours by Stefan Żeromski were subjected to comparative analysis. Prus concentrated on the fate of the orphan and his unequal struggle for a better tomorrow. Żeromski showed the image of the school in the Russian Congress Kingdom of Poland and the struggle of young people against Russification. J. Bryl, in his story, raised the topics of the orphanage and the struggle for linguistic, cultural and national identity.
Wariantywność przekładu w ujęciu diachronicznym na podstawie wybranych tłumaczeń Mistrza i Małgorzaty Michaiła Bułhakowa na język polski
Authors: Sadowska Monika
Published: January 2019

The first edition of one of the most important and mysterious novels of the 20th century appeared more than fifty years ago. Despite the passage of time The Master and Margarita still enjoys popularity; it also intrigues and inspires. Until now five Polish translations of Bulgakov’s novel have appeared. It is known that the interpretation of the original might be expressed in the form of many potential texts that are communicatively equivalent. There is no doubt that it is the translator who plays a vital role in any translation; her/his personality, life experience, knowledge, skills, and also the times s/he lives in regulate the target text. That is why, no matter how many times a text is translated, the final product will always be different. Taking this into consideration, the author will compare the three Polish translations of Bulgakov’s Master and Margarita, paying attention to the diachronic perspective as far as linguistic norms are concerned, the modernity of language, and the way the anthroponyms are expressed.
Wspólnota semantyczno-leksykalna języków europejskich. O monografii: А.А. Кретов, О.М. Воевудская, И.А. Меркулова, В.Т. Титов, Единство Европы по данным лексики (Воронеж: Издательский дом ВГУ, 2016, ss. 413 [1])
Authors: Wojan Katarzyna
Published: January 2019

This article outlines the original research concept developed and applied by the Voronezh researchers, which brought both quantitative and qualitative results to the field of linguistic comparative research. Their monograph is devoted to the macrotypological unity of the lexical semantics of the languages in Europe. In addition, semantic stratification of Russian and Polish lexis has been analyzed. Their research concept is now known as the “lexical-semantic macrotypological school of Voronezh.” Representatives of this school have created a new research field in theoretical linguistics – a lexical-semantic language macrotypology as a branch of linguistic typology. The monograph has been widely discussed and reviewed in Russia.
Życie człowieka w semiotyce koloru na przykładzie języka polskiego i rosyjskiego (część I)
Authors: Narloch Andrzej
Published: January 2019

In the contemporary linguistic research, the colour system occupies a special position. Today’s culture space is supersaturated with colours, which are important semiotic components of human functioning and their relationships with other people. This paper attempts to describe colour semiotics from the point of view of the human’s development period. The author tries to find an answer to the question whether colours can also determine the age frame of a person. First, the relationship between colours and time is analysed. The suggested description of the stages of life through the colour spectrum shall allow answering the question how the respective stages of human life are determined by the colours assigned to them by the culture.
EFFECT OF DICHLOROACETATE ON LEWIS LUNG CARCINOMA GROWTH AND METASTASIS
Authors: Kolesnik D L , Pyaskovskaya O N , Boychuk I V , Dasyukevich O I , Melnikov O R , Tarasov A S , Solyanik G I
Published: January 2019

A hallmark of malignancy is excessive tumor glycolysis, even in the presence of oxygen, which causes lactacidosis in the tumor microenvironment and favors tumor cell proliferation and survival. For this reason antimetabolic agents which target tumor cell metabolism are being researched extensively as promising anticancer drugs. Aim: To study the effect of lactacidosis on survival of Lewis lung carcinoma (LLC) cells at the conditions of nutritional substrate deficiency in vitro and evaluate antitumor and antimetastatic activity against LLC/ R9 in vivo. Materials and Methods: LLC variant LLC/R9 was used as experimental tumor model. Tumor cell viability was determined using trypan blue staining. Apoptosis level was counted with the use of Hoechst 33258 dye. Lactate content in the tumor tissue was evaluated by enzyme method with the use of lactate dehydrogenase. Reactive oxygen species was determined using 2.7-dichlorofluorescein diacetate. Effects of dichloroacetate (DCA) on the growth and metastasis of LLC/R9 were analyzed by routine procedures. Evaluation of DCA effect toward electron-transport chain (ETC) components was performed using EPR. Results: It has been shown that at the conditions of lactacidosis and glucose deficiency, LLC/R9 cell viability in vitro was higher by 30% (р < 0.05) and apoptosis level was triply lower (р < 0.05) than these indices at the conditions of glucose deficiency only. In mice with transplanted LLC/R9 tumors treated for 3 weeks per os with DCA at the total dose of 1.5 g/kg of body weight starting from the next day after tumor transplantation, the primary tumor volume was just by 30% lower than that in control group. At the same time, the number and volume of lung metastases in animals treated with DCA were by 59% (р < 0.05) and 94% (р < 0.05) lower, respectively, than these indices in the control group. DCA treatment resulted in nearly 30% increase (р < 0.05) of lactate content in tumor tissue compared to that in the control, but did not affect significantly the levels of heme iron complexes with NO (at gmed = 2.007) in mitochondrial ETC proteins and Fe-S cluster proteins (at g = 1.94) in tumor cells. Conclusions: It has been shown that lactacidosis significantly promoted LLC/R9 cell survival at the conditions of glucose deficiency in vitro. If LLC/R9 developed in vivo, DCA as the compound with antilactacidosis activity did not suppress significantly the primary tumor growth but exerted significant antimetastatic activity.
USE OF ELASTOGRAPHY FOR CERVICAL CANCER DIAGNOSTICS
Authors: Bakay O A , Golovko T S
Published: January 2019

The aim of the study was to investigate the use of elastography for cervical cancer diagnostics. Materials and Methods: The ultrasonic study with use of sonoelastography involved 87 patients with cervical pathology (cervicitis, n = 11; dysplasia, n = 14; cervical cancer, n = 62). Results: At non-malignant pathology elastic types of elastograms prevailed while the tumors were characterized by images of stiff type formations. Present study has demonstrated an effectiveness of sonoelastography for valuation of tumor process invasion levels. At detection of tumor invasion into parametrium, the test sensitivity increased from 77.1 to 91.4%, specificity — from 85.1 to 96.2%, accuracy — from 80.6 to 93.5%; in case of tumor invasion into vagina these parameters correspondently changed: from 75.0 to 83.3%, from 76.9 to 88.4%, from 75.8 to 85.4%, respectively; and in case of uterus: from 82.9 to 85.3%, from 85.7 to 95.2%, from 83.8 to 88.7%, respectively. Conclusions: Inclusion of elastography into ultrasound examination of cervical pathologies could significantly improve diagnostic quality of the method.
PARAGANGLIOMA-LIKE DERMAL MELANOCYTIC TUMOR: A RARE SKIN LESION
Authors: Zinovkin D A , Aliaksinski V S , Hryb A K , Dedik S Yu
Published: January 2019

Paraganglioma-like dermal melanocytic tumor (PDMT) is a very rare dermal nodule, which resembles clear cell sarcoma and skin melanoma in its morphology. Nowadays about 10 cases of the tumor are described in world literature [1–3].
OVERVIEW ON ASSOCIATION OF DIFFERENT TYPES OF LEUKEMIAS WITH RADIATION EXPOSURE
Authors: Gluzman D F , Sklyarenko L M , Zavelevich M , Koval S V , Ivanivskaya T , Rodionova N K
Published: January 2019

Exposure to ionizing radiation is associated with increasing risk of various types of hematological malignancies. The results of major studies on association of leukemias and radiation exposure of large populations in Japan and in Ukraine are analyzed. The patterns of different types of leukemia in 295 Chernobyl clean-up workers diagnosed according to the criteria of up-to-date World Health Organization classification within 10–25 years following Chernobyl catastrophe are summarized. In fact, a broad spectrum of radiation-related hematological malignancies has been revealed both in Life Span Study in Japan and in study of Chernobyl clean-up workers in Ukraine. The importance of the precise diagnosis of tumors of hematopoietic and lymphoid tissues according to up-to-date classifications for elucidating the role of radiation as a causative factor of leukemias is emphasized. Such studies are of high importance since according to the recent findings, radiation-associated excess risks of several types of leukemias seem to persist throughout the follow-up period up to 55 years after the radiation exposure.
APPLICATION OF SEREX-ANALYSIS FOR IDENTIFICATION OF HUMAN COLON CANCER ANTIGENS
Authors: Garifulin O M , Kykot V O , Gridina N Y , Kiyamova R G , Gout I T , Filonenko V V
Published: January 2019

Background: Colorectal, lung and breast tumors are the most devastating and frequent malignances in clinical oncology. SEREX-analysis of colon cancer leads to identification of more than hundred antigens which are potential tumor markers. With idea that immunoscreening with pool of allogeneic sera is more productive for antigen isolation, SEREX-analysis was applied to four cases of stages II–IV primary colon tumor and 22 new antigens were isolated. Objective: To characterize 22 primary colon cancer antigens isolated by SEREXtechnique. Materials and Methods: Allogenic screening, real-time PCR analysis. Results: After allogeneic immunoscreening, for 5 of 22 (22%) isolated antigens were confirmed colon cancer restricted serological profile solely positive for 14% of tested colon cancer sera. Through these five antigens, KY-CC-17/β-actin has cytoskeleton function; KY-CC-14/ACTR1A and KY-CC-19/TSGA2 participate in chromosome segregation; KY-CC-12/FKBP4 regulates steroid receptor function and KY-CC-15/PLRG1 is a component of spliceosome complex. For the last four antigens tested were found aberrant mRNA expression in some cases of colon tumor. Conclusion: The exploration of identified antigens may define suitable targets for immunotherapy or diagnostic of colon cancer.
ANTICANCER EFFECTIVENESS OF VACCINATION BASED ON XENOGENEIC EMBRYO PROTEINS APPLIED IN DIFFERENT SCHEDULES
Authors: Symchych T V , Fedosova N I , Karaman O , Yevstratieva L M , Lisovenko H S , Voeykova I M , Potebnya G P
Published: January 2019

The aim: To evaluate anticancer activity of vaccination with chicken embryo proteins (CEP) applied in different schedules. Materials and Methods: C57Bl mice were vaccinated with CEP before (prophylactic schedule) or after (different therapeutic schedules with or without preliminary tumor removal) the Lewis lung carcinoma cells transplantation. The latent period of tumor development, tumor volume and metastasis rate were evaluated. Results: Potent antimetastatic effect of CEP-based vaccination was seen in case of therapeutic regimen after primary tumor removal. The metastasis inhibition index (MII) reached 96.9 and 97.8% on 18th and 34th day after tumor removal, respectively. When CEP vaccination was performed in the settings of therapeutic regimen without primary tumor removal the anticancer effect was evident only if vaccinations started as early as 24 h after the cancer cells injections. The highest MII achieved in such condition was 77.6%, tumor volume in the group of vaccinated animals was by 53.1–42.1% lower than in the control tumor-bearing mice. CEP vaccination before tumor challenge (prophylactic immunization) led to a statistically significant prolongation of the latent period of tumor development, a reduction of tumor volume (35.8–48.8% compared to control unvaccinated mice) and a marked inhibition of metastasis (MII was 71.1%). Conclusion: Vaccination based on CEP exhibited both prophylactic and therapeutic anticancer effects. The last one is more pronounced when the vaccination starts shortly after the primary tumor resection.
ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN NON-SMALL CELL LUNG CANCER PATHOGENESIS
Authors: Krupnova E V , Shapetska M N , Mikhalenko E P , Chebotaryova N V , Shchayuk A N , Pissarchik S N , Prokhorov A V
Published: January 2019

The angiogenesis is an important process in the pathogenesis of malignancies. It is regulated by various growth factors, with the vascular endothelial growth factor (VEGF) playing the central role. The aim of the present study was to evaluate possible associations of functional VEGF −2578C>A, −634G>C, and +936C>T polymorphisms with the risk for occurrence and progression of non-small cell lung cancer (NSCLC) in patients living in Republic of Belarus. Materials and Methods: A total of 202 patients (147 males and 55 females) diagnosed as having the NSCLC. The control group consisted of 336 individuals (245 males and 91 females) without an oncopathology. The total DNA was isolated from peripheral blood. We investigated the single nucleotide polymorphisms of VEGF (rs 2010963), (rs 699947), (rs 3025039). The genotyping was performed by PCR-RFLP analysis. Results: Our results revealed a marginally significant association of the –2578CC genotype (p=0.002) with a greater degree of tumor spread (Т2–Т4). Heterozygous genotypes –2578СА and +936СT carriers were included into the follow-up group significantly more often (р=0.021 and р=0.012, respectively). Our study demonstrate that VEGF –2578A/C and +936C/T polymorphisms are among the factors determining the individual peculiarities of NSCLC course in this population and can be used for clarifying the prognosis of the disease.
PLASMA HOMOCYSTEINE, FOLATE AND VITAMIN B12 LEVELS IN PATIENTS WITH LUNG CANCER
Authors: Tastekin D , Erturk K , Bozbey H U , Olmuscelik O , Kiziltan H , Tuna S , Tas F
Published: January 2019

Aim: Disorders in the metabolism of homocysteine and B vitamins, which are involved in a one-carbon transfer reaction and important for DNA synthesis and methylation, have been hypothesized to be associated with carcinogenesis. The purpose of this study is to evaluate the levels of homocysteine, vitamin B12 and folic acid in patients with newly diagnosed lung cancer and determines whether they might be used as an accurate tumor marker for monitoring the patients if they are found to be elevated in lung cancer. Materials and Methods: Forty male patients with lung cancer were included in this study. Age-matched forty healthy males who had not malignant disease or had not received any drug affecting plasma homocysteine levels were selected as control group. Homocysteine, vitamin B12 and folate levels were measured in the samples obtained from the patients and controls. Results: Mean age of the patients with lung cancer was 58.7 ± 9.9 years. All the patients were cigarettes smokers. Mean daily consumption of cigarettes was 2.0±0.7 packs and mean duration of smoking was 30 ± 11 years. Histologic type of carcinoma was found to be squamous cell carcinoma in 55%, adenocarcinoma — in 35%, and small cell carcinoma — in 10% of the cases. Clinical stage was stage IA in 20%, stage IB — in 20%, stage IIA — in 2.5%, stage IIB — in 10%, stage IIIA — in 12.5%, stage IIIB — in 20%, and stage IV — in 15% of the cases. Mean homocysteine level was 15.3 ± 7.3 μmol/l in the patients with lung cancer while 9.8 ± 2.6 μmol/l in controls. Homocysteine level was significantly higher in the patients with lung cancer compared to control group (p < 0.001). Mean folate level was 4.3 ± 1.8 pg/ml in cancer cases while 6.1 ± 2.3 pg/ml in controls. That is to say, plasma folate levels were significantly lower in cases of lung cancer compared to controls (p < 0.001). There was no significantly difference between groups with regard to B12 levels (mean B12 level was 234 ± 99 and 240 ± 104 ng/ml in the patients with lung cancer and controls, respectively, p = 0.78). Plasma homocysteine, vitamin B12 and folate levels did not show significant difference with respect to histologic type of carcinoma. No significant correlation was found between plasma homocysteine, vitamin B12, folate levels and number of cigarettes smoked per day, duration of smoking, age of the patient, and clinical stage of carcinoma. There was also no correlation between number of cigarettes smoked per day, duration of smoking, age of the patient and clinical stage of carcinoma. A possible inverse correlation between plasma homocysteine, vitamin B12 and folate levels was not observed. Conclusion: In conclusion, high plasma homocysteine and low folate levels could be associated with lung cancer. However, further studies performed on large patient population are needed.
UNUSUAL METASTASES OF LUNG CANCER: BULBUS OCULI AND MAXILLARY SINUS
Authors: Ates I , Yazici O , Ates H , Ozdemir N , Zengin N
Published: January 2019

Lung adenocarcinoma often makes metastasis to the brain, liver, kidneys, bone, bone marrow and adrenal glands. It can also make metastasis to other parts of the body rarely for example eye, nose, parotid gland and paranasal sinus. We did not encounter with combined ocular bulbus and the maxillary sinus metastases of lung cancer in the accessible literature. In this case report, a patient who was combined ocular bulbus and the maxillary sinus metastases of lung adenocarcinoma will be discussed.
ENDOTHELIAL DYSFUNCTION OF VESSELS AT LUNG CANCER
Authors: Dumanskiy Yu V , Stoliarova O Yu , Syniachenko O V , Iegudina E D
Published: January 2019

Aim: To evaluate changes in indicators of endothelial function and their relationship with morphological forms of disease, stage of pathological process and tumor markers, by analysis the peripheral blood of lung cancer (LC) patients. Materials and Methods: 38 LC patients without metastases (mean age — 57 years) prior chemo- and radiotherapy were included in the study. The duration of the disease manifestation was 18 months. 21% of patients had small cell LC, and the rest — non-small cell LC. The ratio of patients with stages IA, IB, IIA, IIB, IIIA and IIIB LC was 1 : 3 : 3 : 4 : 4 : 4. The enzyme immunoassay, spectrophotometry, and statistical data analysis were used. Results: Endothelial dysfunction of vessels was characterized by increased blood levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET1), homocysteine (HCys), cyclic guanosine monophosphate (cGMP), P-selectin (PSel) and nitrites (NO2) and simultaneously by decreased values of prostacyclin (PgI2). Those were observed in 100; 90; 76; 71; 50; 53 and 79% of LC cases, respectively. Disturbances of vascular endothelial function were associated with patient’s age, disease duration, and morphological form and LC stage. Such changes were observed in women with higher prevalence. The studied indices correlated with tumor markers, namely transforming growth factor beta (TGFβ1), fibronectin and osteopontin. Conclusion: Indices of vascular endothelial dysfunction in LC can be of diagnostic and prognostic value.
INTRAOPERATIVE ULTRASONOGRAPHY IN PANCREATIC SURGERY: STAGING AND RESECTION GUIDANCE
Authors: Kolesnik O , Lukashenko A , Shudrak A , Golovko T , Lavryk G , Huralevych J
Published: January 2019

Background: Intraoperative ultrasound examination (IOUS) is indispensable part of modern surgical interventions in tumors of hepatopancreatobiliary zone. In this study retrospective analysis of IOUS efficiency in surgical treatment of pancreatic tumors was provided. Materials and Methods: In the period from January 2013 till November 2015 in the National Cancer Institute IOUS was applied during 76 surgical interventions: for pancreatic head tumors — in 46 (60.5%) patients, for body/tail pancreatic tumors — in 20 (26.3%) patients, in 10 (13.2%) patients — for periampullary zone neoplasms. In IOUS we performed primary tumor assessment (localization, degree of tumor spreading to superior mesenteric vessels, hepatoduodenal ligament vessels, additional foci occurrence in pancreas), and liver metastases detection. Surgical interventions were performed: pancreatoduodenectomy in 52 (68.4%) patients, radical antegrade modal pancreatosplenectomy — in 14 (18.4%) patients. Results: IOUS allowed determining additional tumor foci in pancreas in 2 (2.6%) patients, in 8 (10.5%) observations tumor invasion into portal or superior mesenteric vein was determined. In 21 (27.6%) patient additional hepatic neoplasms were detected (in half of cases — 11.8%, metastases). These findings resulted in change of surgical intervention extent in 23 (30.3%) patients: expansion to combined resections in 14 (18.4%) patients, reduction to symptomatic operations in 5 (6.6%) cases, organ-preserving operations were performed in 4 (5.3%) patients. Variant anatomy of hepatic arterial blood supply was determined in 41 (53.9%) patients that necessitated performance correction of resection stages for preservation of adequate hepatic blood supply. Conclusions: IOUS is a highly-precise diagnostic method substantively influencing operation course in pancreatic tumors, enabling surgeon to provide adequate staging and permanent correction of operation course.
TREATMENT OF METASTATIC HEAD AND NECK CANCER WITH MESENCHYMAL STEM CELLS COMBINED WITH PRODRUG GENE THERAPY
Authors: Lakota J , Gocarova K , Spanik S
Published: January 2019

This is a clinical observation of a patient treated for metastatic head and neck cancer with mesenchymal stem cells mediated prodrug gene therapy. The cells were applied intravenously. We did not observe any therapeutic effect. However, a temporal bicytopenia was observed.
RADIOPROTECTIVE PROPERTIES OF SODIUM HUMATE IN RADIATION-INDUCED MUTAGENESIS IN CULTURED LYMPHOCYTES OF THYROID CANCER PATIENTS
Authors: Shkarupa V M , Klymenko S V
Published: January 2019

Aim: To investigate the effect of sodium humate on the level of cytogenetic damage in culture of lymphocytes of patients with thyroid cancer after γ-irradiation. Materials and Methods: Metaphase analysis of chromosome aberrations in cultured peripheral blood lymphocytes of 10 individuals with thyroid cancer was performed after irradiation of lymphocytes in vitro at a dose of 1 Gy from 137Cs source at the early G0 phase of cell cycle. Sodium humate was added to cell culture for 30 ± 15 min after phytohemagglutinin stimulation at concentrations of 10 and 100 μg/ml. Results: Sodium humate exhibited antimutagenic properties. The preparation at a concentration of 10 μg/ml was more effective than at a concentration of 100 μg/ml, reducing the average incidence of radiation-induced chromosome aberrations by 51.88 and 38.77%, respectively. The most pronounced antimutagenic effect of sodium humate was the reduction of the frequency of chromosomal type aberrations, however, such efficiency varied between individual patients with thyroid cancer. Conclusions: Sodium humate could be considered as a potential therapeutic modifier of radiation damage.
CLINICOPATHOLOGICAL FEATURES OF NONSPECIFIC INVASIVE BREAST CANCER ACCORDING TO ITS MOLECULAR SUBTYPES
Authors: Zavyalova M , Vtorushin S , Telegina N , Krakhmal N , Savelieva O , Tashireva L , Bragina O , Denisov E , Kaigorodova E , Slonimskaya E , Choynzonov E , Perelmuter V
Published: January 2019

The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type — in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer — in 25 women. Results: The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups. Conclusion: The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably.