bluuebunny/crossref_metadata_2025 huggingface dataset:
Parametric Comparison of Selected Dual Elements PIR Sensors
Authors: Rafique Faisal , Siddiqui Najeeb
Published: August 2023

Most of the warm blooded animals emanate thermal radiations in the MWIR to LWIR (Medium Wave to Long Wave Infrared) range from 3μm to 18μm. If the object is warmer than the surroundings, its thermal radiation is shifted toward higher frequency within the band and the thermal flux rate becomes stronger. To detect radiation in this band, single and multi-elements pyroelectric sensors utilized in the scanning systems to detect, with background contrast, the presence of still or moving thermal objects emitting thermal flux in the bandwidth specified. PIR sensors are commonly used to detect these radiation, their response is further processed by electronic systems and generally analyzed by software embedded systems. Here we present a comparative study of commercially available PIR sensors. In this study we evaluated dual element PIR sensors for their electrical and thermal parameters. Two types of test procedures were used, which can be used for any type of PIR sensors.
SOSIALISASI PENCEGAHAN PADEMI CORONA MELALUI CARA HIDUP BERSIH DAN SEHAT DI KALANGAN MASYARAKAT BENTIRING PERMAI KECAMATAN MUARA BANGKAHULU KOTA BENGKULU
Authors: Royan Antory , Hatrik Hamzah
Published: August 2023

COVID-19 membuktikan diri mampu menular antarmanusia. Penularan sangat cepat hingga Organisasi Kesehatan Dunia WHO menetapkan pandemi virus Corona atau COVID-19 . Pandemi atau epidemi global mengindikasikan infeksi COVID-19 yang sangat cepat hingga hampir tak ada negara atau wilayah di dunia yang absen dari virus Corona pemahaman masyarakat dan  pencegahan infeksi virus Corona atau COVID-19  di kalangan masyarakat Kelurahan Bentiring Permai Kecamatan  Muara  Bangkahulu Kota Bengkulu Virus Corona atau severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adalah virus yang menyerang sistem pernapasan. Penyakit karena infeksi virus ini disebut COVID-19. Virus Corona bisa menyebabkan gangguan ringan pada sistem pernapasan, infeksi paru-paru yang berat, hingga kematian. Terapkan physical distancing, yaitu menjaga jarak minimal 1 meter dari orang lain, dan jangan dulu ke luar rumah kecuali ada keperluan mendesak. Gunakan masker saat beraktivitas di tempat umum atau keramaian, termasuk saat pergi berbelanja bahan makanan. Rutin mencuci tangan dengan air dan sabun atau hand sanitizer yang mengandung alkohol minimal 60%, terutama setelah beraktivitas di luar rumah atau di tempat umum.
Putusan Yang Memberi Efek Jera Pada Pelaku Korupsi, Kolusi dan Nepotisme
Authors: Agusalim Agusalim
Published: August 2023

Putusan Yang Memberi efek Jera Pada Pelaku Korupsi, Kolusi dan Nepotisme
Tanggung Jawab Negara Pengirim Terhadap Penyalahgunaan Hak Kekebalan Oleh Pejabat Diplomatik
Authors: Chairunnisa Nianda Nabilla , Waryenti Deli , Muthia Arini Azka
Published: August 2023

Pada tahun 2015 dan 2016, Sekretaris I Kedutaan Besar Korea Utara untuk Bangladesh, dipersona non grata setelah tertangkap menyelundupkan sejumlah barang yang sama sekali tidak ada hubungannya dengan pelaksanaan misi diplomatik di negara penerima. Penelitian ini berupaya menjabarkan bagaimana pengaturan tanggung jawab negara pengirim terhadap penyalahgunaan hak kekebalan oleh pejabat diplomatik berdasarkan hukum internasional. Penelitian ini merupakan penelitian hukum normatif. Hasil penelitian menunjukkan bahwa pengaturan mengenai tanggung jawab negara pengirim terhadap penyalahgunaan hak kekebalan oleh pejabat diplomatik pada dasarnya telah diatur dalam hukum internasional, yaitu melalui Konvensi Wina 1961 tentang Hubungan Diplomatik, asas dan prinsip hukum umum pacta sunt servanda dan itikad baik.
Telaah Kritis Prinsip Prinsip Dasar Dalam Pemilihan Kepala Negara dan Musyawarah
Authors: Darudin Mohammad
Published: August 2023

Dalam pespektif Hukum Islam, pemilihan kepala negara merupakan kepentingan bersama dalam kehidupan berbangsa dan bernegara. Terpilihnya kepala negara yang kredibel, ligitimid dalam sistem pemilihan yang demokratis berpegang teguh pada prinsip prinsip dasar musyawarah dalam majlis syura merupakan suatu keniscayaan atas terbentuknya walfare state/negara sejahtera/masyarakat madani. Sejarah telah membuktikan bahwa penerapan prinsip-prinpdasar musyawarah dalam pemilihan kepala negara yang bersumberkan nilai nilai dalam al-Quran dan hadis mampu melahirkan seorang kepala negara yang kredibel, ligitimed  sebagaimana telah terjaddi pada masa kepemimpinan Nabi Muhammad dalam membangun kota Madinah dengan Piagam Madinah Nabi muhammad berhasil mempersatukan 13 komunitas yang bertikai dan mampu meningkatkan kesejahteraan rakyatnya. Keberhasilan ini kemudian dilanjutkan pada masa kepemimpinan khulafaurrasyidin, sahabat seniornya Abu Bakar, Umar, Usman dan Ali bin Abu Thalib. Keberhasilan ini sebagai konsekuensi logis dari penerapan prinsip-prinsip dasar musyawarah dalam majlis syura dalam menyelesaikan berbagai persoalan kehidupan sosial, ekonomi, budaya dan hukum serta dalam menyelesaikan persoalan pemilihan kepala negara.
PELAKSANAAN ASURANSI USAHA TANI PADI DI KOTA BENGKULU
Authors: Khairani Rahma , Ganefi Ganefi , Hermansyah Edi
Published: August 2023

Asuransi Usaha Tani Padi (AUTP) merupakan program pemerintah yang bertujuan memberi perlindungan terhadap petani di Indonesia apabila terjadi gagal panen yang risiko kerugiannya akan dialihkan ke perusahaan asuransi pelaksana. Masih banyak petani yang belum menyadari pentingnya mengasuransikan lahan padi yang dikelolah, sehingga peminat Asuransi Usaha Tani Padi masih tergolong rendah khususnya di Kota Bengkulu. Tujuan penelitian ini adalah: (1). Untuk mengetahui penyebab petani tidak mengikuti AUTP di Kota Bengkulu; (2). Untuk mengetahui upaya yang dilakukan Dinas Pangan dan Pertanian agar Keputusan Menteri Pertanian Nomor: 01/Kpts/Sr.230/B/01/2021 Tentang Pedoman Bantuan Premi Asuransi Usaha Tani Padi di Kota Bengkulu dapat terlaksana. Metode penelitian adalah jenis penelitian empiris dengan pendekatan sosio legal research, penelitian bertitik tolak dari data primer langsung dari sumber pertama melalui penelitain lapangan. Metode pengumpulan data meliputi, wawancara dan pengumpulan data sekunder. Hasil penelitian: (1). Kurangnya informasi yang jelas mengenai AUTP sehingga menimbulkan spekulasi tersendiri dari petani yang menganggap bahwa untuk menjadi peserta AUTP harus sesuai dengan syarat-syarat tertentu yang dirasa tidak dapat dipenuhi oleh petani di Kota Bengkulu. Proses klaim ganti kerugian tergolong lamban, akibatnya petani yang pernah menjadi peserta tidak ingin kembali menjadi peserta AUTP untuk musim tanam selanjutnya. (2). Upaya yang dilakukan oleh Dinas Pangan dan Pertanian Kota Bengkulu, berupa upaya preventif dengan melakukan sosialisasi AUTP ke petani di Kota Bengkulu, melakukan pendampingan pendaftaran dan pembayaran premi AUTP, serta Upaya Represif berupa pendampingan klaim AUTP dan evaluasi pelaksanaan AUTP.
A COMPARATIVE STUDY OF VICTIM PROTECTION ON THE DOMESTIC VIOLENCE ACCORDING TO LAW IN INDONESIA AND MALAYSIA
Authors: Oktrina Faiha
Published: August 2023

The United Nations as a representation of the international community even accommodates regulations related to human rights through International Treaties agreed upon by state parties in the world through the Universal Declaration of Human Rights. Domestic violence is one of the most violence that occurred in many countries, which happens in Indonesia and Malaysia. Any violence between current or past intimate partners, wherever and whenever the abuse happens, is considered domestic violence (breach of human right). Physical, sexual, emotional, and financial abuse are all potential forms of violence. Indonesian law and Malaysian law define domestic violence as any act against a person, especially a woman, that results in physical, sexual, psychological, and/or domestic neglect or suffering including threats to commit acts, coercion, or unlawful deprivation of liberty within the domestic sphere. Research in a positive direction without excluding the elements of harmonization and legal politics that exist within the scope of the Republic of Indonesia and the Federated States of Malaysia in the realm of Domestic Violence entitled “A COMPARATIVE STUDY OF THE DOMESTIC VIOLENCE LAW IN INDONESIA AND MALAYSIA” according to Law No. 23 of 2004 on the Elimination of Domestic Violence and Domestic Violence Act 521 of 1994 jo. Domestic Violence Act A1538 2017. In this research, the researcher uses normative legal research, there are two types of groupings, consisting of primary legal material and secondary legal material.
PERJANJIAN SEWA MENYEWA KAPAL PENANGKAP IKAN NELAYAN TRADISIONAL (KAJIAN SOSIOLOGI HUKUM)
Authors: Budi Ambarini Nur Sulistyo
Published: August 2023

Sewa menyewa kapal merupakan suatu bentuk perjanjian yang  dilakukan nelayan tradisional   dalam memenuhi kebutuhan sarana prasarana penangkapan ikan. Penelitian ini bertujuan untuk mengkaji latar belakang perjanjian sewa menyewa kapal penangkap ikan oleh nelayan tradisional dan pemilik/jurgan penyedia kapal dalam perpektif sosiologi hukum. Perjanjian sewa menyewa secara umum merupakan kegiatan ekonomi. Tetapi dalam hal obyeknya kapal penangkap ikan oleh nelayan,  tidak hanya persoalan ekonomi. Oleh karena itu penelitian ini berupaya mengkaji persoalan apa yang melatarbelakangi perjanjian sewa menyewa kapal penangkap ikan oleh nelayan tradisional dan pemilik kapal. Penelitian hukum non doktrinal ini pendekatan socio-legal research, dengan lokasi penelitian di wilayah pesisir Kota Bengkulu. Hasil penelitian menunjukkan bahwa perjanjian sewa menyewa kapal dilakukan secara lisan (tidak tertulis) dalam masyarakat nelayan tradisional. Hubungan sewa menyewa antara nelayan tradisional dengan juragan pemilik kapal pada dasarnya tidak hanya dilatarbelakangi oleh persoalan ekonomi, tetapi juga aspek sosial dalam masyarakat pesisir. Budaya kebersamaan dan hubungan patron-klien sangat mempengaruhi perjanjian sewa menyewa kapal antara nelayan tradisional dengan nelayan juragan pemilik kapal.

Kata Kunci: Hukum, Nelayan; Perjanjian; Sewa-menyewa; Tradisional
ALASAN MASYARAKAT MEMILIH PENYELESAIAN DELIK ADAT KERAP GAWIH OLEH MASYARAKAT ADAT BESEMAH DI KECAMATAN TANJUNG KEMUNING KABUPATEN KAUR
Authors: Eryke Herlita , Maliki Jefi
Published: August 2023

Meningkatnya tindak pidana asusila dikalangan masyarakat salah satunya yang sering terjadi yakni perzinahan. Tindak pidana asusila yang terjadi di provinsi Bengkulu hingga Oktober 2020 terdapat 158 kasus. Delik perzinahan diatur dalam pasal KUHP yang merumuskan bahwa hubungan seksual diluar pernikahan merupakan suatu kejahatan. Penelitian ini bertujuan untuk mengetahui alasan masyarakat Adat Besemah melakukan penyelesaian delik Adat Kerap Gawih melalui musyawarah masyarakat Adat Besemah di Kecamatan Tanjung Kemuning kabupaten Kaur. Metode analisis yang digunakan dalam penelitian ini yaitu metode analisis kualitatif. Data dikumpulkan baik dari kepustakaan maupun dari penelitian di lapangan. Hasil penelitian menunjukan bahwa masyarakat Adat Besemah di Tanjung Kemuning kabupaten Kaur melakukan penyelesaian dengan proses yang lebih mudah dan cepat yaitu melalui proses penyelesaian Delik Adat Kerap Gawih karena hanya memerlukan waktu yang singkat dan biaya yang sedikit.

 

Kata Kunci: Delik Adat Kerap gawih, Musyawarah Adat, Tindak Pidana Asusila
Determinants of Post-Tax Audit Compliance in Ghana
Authors: IDDRISU ZAAPAYIM ABDUL JALIL MAHAMA ALHASSAN
Published: August 2023

Governments derive a significant portion of their income from taxation. Collection of tax is however impeded by tax non-compliant activities as well as tax evasion. This necessitates measures to ensure tax compliance, such as tax audits. The study looked into the factors that influence taxpayers' post-audit compliance behavior in Ghana, with the Ho and Hohoe Small Taxpayer Offices as a case study. The focus of the study was on the effectiveness of tax audit procedures, post-tax audit compliance behavior of taxpayers, and taxpayers' experience with tax officers during and after the first tax audit. To achieve this aim, the study utilized the case study method of research. The researcher used the purposive sampling technique to select respondents for the questionnaire survey. The primary goal of the research was to investigate the efficacy of tax audit methods. The study identified that tax audit procedures were most effective in the Ho and Hohoe Small Taxpayer offices. The effectiveness of the audit procedures was ensured through the thorough examination of all relevant books and documents by skilled auditors. The second purpose of the study was to investigate the post-tax audit compliance behaviour of taxpayers. The study found that, after the audit procedures, taxpayers started filing tax returns accurately and timely. This improvement was primarily due to the level of education provided by tax officers during tax audits. Finally, the last objective sought to examine taxpayers' experience with tax officers during and after the first tax audit. The study found that there were very few cases (11.40%) where respondents agreed that auditors compelled them to do something to reduce the tax. However, tax officers endeavored to provide legal backing and explanation for every decision made. The learning process that tax officers took taxpayers through has built a cordial relationship between the two parties. Tax audits, when structured to ensure proper collection of taxes, can lead to minimal tax avoidance and tax evasion and strict compliance with the applicable tax laws, and an enhanced degree of voluntary tax compliance.
Teacher Competency Development Management in Mts Istiqlal Deli Tua Serdang Regency
Authors: Fuadi Muhammad Irjaul , Rohman Fatkhur
Published: August 2023

Teacher development management is an effort that is carried out through activities, training and development of the abilities possessed by educators individually/groups to achieve the desired goals by managing teaching staff. The purpose of writing this research is to find out how the management of teacher competency development is at MTs Istiqlal Deli Tua. The method used in this research is using descriptive qualitative research method. The results of the study show that the Management of Teacher Competency Development at MTs Istiqlal Deli Tua includes three stages of activity namely planning, implementation/implementation and evaluation of teacher competency development. First, Planning for teacher competency development at MTs Istiqlal Deli Tua by way of 1). annual planning which is held during madrasah work meetings and direct monitoring from the head of the field. 2). planning at a certain time which is carried out during weekly work meetings with the aim of knowing the constraints felt by teachers so that training for teachers can be held. Second, the application/implementation of teacher competency development at MTs Istiqlal Deli Tua there are 4 teacher competencies which include: 1). Teacher pedagogic competence by participating in seminars, workshops, training both held at school and outside school, 2). Personal competence by providing activities in the form of recitation/consultation for teachers by calling ustadz/resource persons 3). Teacher professional competence by involving teachers in training workshops, seminars and interesting training in accordance with the subject matter taught by the teacher, 4). social competence of teachers with hospitality activities between teachers. Third, evaluation of teacher competency development through weekly evaluations, and academic supervision.
Development of Higher Order Thinking Skills-Based Multiple Choice Test Items Using Quizizz Application to Measure the Cognitive Abilities of Early Childhood Students in the Early Beginning Classes
Authors: Hidayati Tuti , Yudha Rivo Panji
Published: August 2023

The purpose of this research is to determine the development of Higher Order Thinking Skills (HOTS)-based multiple-choice question instruments through Quizizz application to measure the cognitive abilities of early childhood students in the early grades. The method used in this study is the research and development ADDIE method. The results of this study show that the developed HOTS instrument using Quizizz meets the validity criteria based on validity tests. The results of content validity test by subject matter experts indicate 90% validity with a highly valid category, while the media experts' validation results show 83% validity with a highly valid category. The practicality questionnaire validation results from the students indicate 85% validity with a highly valid category. The results of construct validity test state that each item has a calculated r-value higher than the table r-value, indicating its validity and suitability for use. The reliability test yields a value of 0.799, which falls under the high reliability category with a range of 0.600-0.800. The difficulty level test results, with an average of 0.73, indicate that the questions are easy, demonstrating good quality difficulty levels. The item discrimination test results show an average of 0.432, indicating good discriminatory ability. The practicality test results from the students show 89% practicality with a highly practical category. Based on the test results of the students' abilities after being given the questions, it can be concluded that out of the 97 students who answered the 20 HOTS multiple-choice questions, 55 students had an excellent level of ability, 10 students had a good level of ability, 27 students had an average level of ability, and 5 students had a very poor level of ability. Thus, the average score of the 97 students is 71%, falling under the good category.
Thumb Carpometacarpal Osteoarthritis
Authors:   , Ottenhoff Janna Sophie Eugenia
Published: August 2023

SUMMARY

Osteoarthritis of the basal thumb joint is part of normal human aging: everyone gets it if we live long enough. Thumb pain can cause reduced pinch strength and impaired hand capability such as difficulty opening jars or turning a key. Symptom intensity does not correlate with the severity of basal thumb osteoarthritis on radiographs. Acceptance and adaptation in daily life are the primary treatment goals. This can often be achieved with splints and analgesics; surgery is not necessary. Notwithstanding, numerous surgical options are available but there is no consensus about which surgical treatment is most effective. The aim of this thesis was to explore patients’ and surgeons’ perspectives on basal thumb osteoarthritis, and discuss outcomes of surgical treatment by pyrocarbon disc and joint distraction.

CONCLUSIONS

1. Online information on CMC1 osteoarthritis is often difficult to read and biased in
favor of a particular treatment. Clinicians should be prepared to gently reorient
any misconceptions about the etiology (it is not an acute injury but part of human
aging) and on the effectiveness of treatment options (adaptation is the foundation
of healthcare, a surgical “quick fix” does not exist).

2. There is surgeon-to-surgeon variation in testing (obtaining radiographs) and
treatment (injection and surgery) for CMC1 osteoarthritis. Surgeons seem to base
their recommendations for operative treatment largely on subjective factors.
Shared decision making and decision aids may help ensure that a treatment
choice is not based on misconceptions or surgeon preferences, and instead
reflects the personal values of the patient.

3. If implant displacement occurs after pyrocarbon disc interposition arthroplasty
for CMC1 osteoarthritis, most people do not experience pain or limitation in their
daily activities. Revision surgery is performed in about 1 out of 10 people mainly
because of dissatisfaction with pain alleviation (which does not correspond
with radiographic findings). Given this lack of correspondence, the role of the
pyrocarbon interposition is open to debate, and revision surgery is not needed
based on the radiographic findings alone.

4. Temporary joint distraction is a technically feasible treatment for people with
CMC1 osteoarthritis. Application of this technique was associated with a second
surgery for arthroplasty among one of 20 patients within two years. Larger,
randomized, comparative studies are needed to be sure that this distraction
alleviates symptoms better than simulated distraction and to assess the exact place
of joint distraction in treatment of CMC1 osteoarthritis.
Need for negativity
Authors:   , Peerboom Carlijn Nicolle Elise
Published: August 2023

Our brain is a fascinatingly complex organ comprised of a network of millions of brain cells (neurons), and their connections (synapses). Neurons come in two types: excitatory and inhibitory. When an excitatory neuron is active, it will send positive electrical signals through its excitatory synapses to the next neurons in the network. When an inhibitory neuron is active, it will provide subsequent neurons with negative electrical signals via its inhibitory synapses. All positive and negative signals simultaneously received by a brain cell, determine whether the cell will become active itself and will pass its electrical signals on to the next cells in the network.

The development of the brain starts already in the womb. Genes provide the blueprint for the first steps in network formation. In addition, network development is directed by spontaneous neuronal activity generated by excitatory signaling. Excitatory signals allow the fetal neuronal network to grow quickly by stimulating neuronal proliferation, synapse formation and synaptic strengthening. At this time, excitation is mainly provided by a substance called gamma-aminobutyric
acid or GABA.

Only later on, sensory experiences start affecting the electrical activity in the network. Around the same time, GABA is changing from being excitatory, to inhibitory. Excitation is now provided by another signaling molecule, called glutamate. Inhibition enables the brain to handle an enormous amount of external stimuli in a controlled manner by filtering out irrelevant inputs and only passing on relevant stimuli. The gradual developmental change in the function of GABA from excitation to inhibition is called the GABA shift. During my PhD, I studied the GABA shift in brain slices from mice. Brain development in mice and humans is very similar, though much faster in mice. In comparison: in humans, GABA shifts during the last three months of pregnancy, in mice during the first two weeks after birth.

To measure the GABA shift in murine brain slices, we tested a new sensor. We could discern the GABA shift by comparing dozens of neurons in slices of different ages. In addition, we used the sensor to investigate the effect of early life stress on the GABA shift. Stress seemed to delay the GABA shift in young mice. This study underlines the role of experience in brain development, which allows for adaptability, but also leads to vulnerability.

We also investigated the consequences of accelerating and delaying the GABA shift. Previous studies have shown that the excitatory GABA promotes synapse formation. Therefore, we expected that a delayed GABA shift would result in an overproduction of synapses. However, this is not what we observed when we manipulated the GABA shift in slices from one week-old mice. We saw that a delayed GABA shift did not affect synapses, but found indirect changes in the neurons’ electrical properties. This work is important for neurodevelopmental disorders such as autism, in which the GABA shift often seems delayed. Our research shows that such a delay affects further brain
development.
STRATEGI PEMASARAN SOSIAL INDORELAWAN UNTUK MENINGKATKAN MINAT MENJADI RELAWAN DALAM KAMPANYE â€œTEMALI PROJECTâ€
Authors: Sutresna Asep Sutresna , Saputro Eko Hadi
Published: August 2023

ABSTRAK

Temali Project adalah kampanye program yang dilakukan oleh Indorelawan, sebuah organisasi nirlaba yang menggerakkan masyarakat dalam aksi sosial, untuk mengajak khalayaknya menjadi relawan. Ini merupakan salah satu dari program yang dilakukan oleh Indorelawan untuk mempromosikan kerelawanan dan menjadikan kerelawanan sebagai gaya hidup di Indonesia. Dalam melakukan kampanye sosial yang efektif maka diperlukan disiplin kampanye yang menyeluruh dan terukur. Dengan metode kualitatif deskriptif menggunakan studi kasus, setiap langkah dari kampanye digali menjadi data yang dapat dibandingkan dengan model yang digunakan. Sebagai standar pelaksanaan kampanye sosial digunakan model Social Marketing Planning Premier dari Kotler dan Lee (2016) dan juga Media Richness Theory yang untuk menganalisis kampanye ini. Data didapatkan melalui wawancara mendalam dengan key informan, partisipan dan narasumber. Dari hasil analisis, ditemukan bahwa meskipun secara umum sudah selaras dengan model yang digunakan, ada beberapa langkah yang perlu dibuat lebih rinci dalam perencanaanya sehingga akan menghasilkan kampanye yang efektif dan terukur. Kampanye Indorelawan akan lebih efektif apabila perencanaanya lebih rinci dan terukur, sehingga setiap langkahnya mudah diukur. Dengan membuat perencanaan yang rinci akan memberikan data dan informasi yang jelas yang akan digunakan sebagai standar kampanye Indorelawan.

Kata kunci: Temali Project, Indorelawan, Social Marketing, Kampanye Media Sosial
PENGARUH POSTINGAN AKUN INSTAGRAM @ABOUTTNG TERHADAP PEMENUHAN KEBUTUHAN INFORMASI KULINER FOLLOWERS
Authors: Santi Endang Tri , Amelia Mela , Mulyasih Rahmi
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh postingan akun instagram @abouttng terhadap pemenuhan kebutuhan informasi kuliner followers. Penelitian ini menggunakan paradigma positivis, pendekatan kuantitatif, dan menggunakan teori uses and gratification. Populasi dalam penelitian ini berjumlah 100 responden, dengan teknik pengambilan sampel menggunakan metode Simple Random Sampling yaitu pemilihan sampel secara acak, dimana setiap anggota populasi memiliki kesempatan yang sama untuk terpilih menjadi sampel. Data penelitian diperoleh dengan teknik kuesioner menggunakan skala ordinal sedangkan data pendukung didapat dari kepustakaan. Hasil penelitian ini menunjukan bahwa postingan akun instagram @abouttng memiliki pengaruh terhadap pemenuhan kebutuhan informasi kuliner followers. Hasil perhitungan nilai RSquare sebesar 0,675 menjelaskan bahwa 45% akun instagram @abouttng berpengaruh terhadap pemenuhan kebutuhan informasi  kuliner sedangkan 55% sisanya dipengaruhi oleh variable lain yang tidak diteliti dalam variable ini. Hasil uji hipotesis menunjukan bahwa terdapat pengaruh yang signifikan terhadap postingan akun Instagram terhadap pemenuhan kebutuhan informasi kuliner followers.

Kata Kunci: Teori Uses and Grafitication, Instagram, Kebutuhan Informasi
PERAN KEPEMIMPINAN MINANGKABAU UNIVERSAL DALAM PENINGKATAN KINERJA USAHA RINTISAN GENERASI MILLENIAL DI KOTA PADANG
Authors: Andriani Chichi , Thaib Ilham
Published: August 2023

Penelitian ini bertujuan untuk mengetahui peran Kepemimpinan Minangkabau Universal terhadap kinerja usaha rintisan generasi millennial di kota Padang. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan deskriptif kuantitatif. Adapun objek objek dari penelitian adalah seluruh usaha rintisan generasi millenial yang berada di kota Padang, dengan populasi seluruh seluruh coffee shop yang berada di kota Padang. Teknik pengambilan sampel menggunakan teknik purposive sampling, sehingga sampel penelitian ini adalah adalah sebanyak 180 coffee shop yang ada di kota Padang. Jenis data yang digunakan adalah data primer dengan metode pengumpulan data kuesioner. Teknik analisis data dalam penelitian ini adalah menggunakan analisis regresi sederhana dengan semua data telah memenuhi uji asumsi klasik, uji validitas dan realibilitas. Dari hasil penelitian diperoleh bahwa Kepemimpinan Minangkabau Universal memberikan peran dan pengaruh yang positif dan signifikan terhadap kinerja usaha rintisan generasi millennial di kota Padang.

Kata Kunci: Kepemimpinan Minangkabau Universal, Kinerja
A csökkent bal kamrai ejekciós frakcióval járó szívelégtelenség gyógyszeres kezelésének fejlődése: a gyorstitrálási stratégia klinikai jelentősége
Authors: Varjas Norbert , Hepp Tamás , Benczúr Béla
Published: August 2023

A krónikus szívelégtelenség morbiditása és a mortalitása továbbra is magas, mely miatt a betegség megfelelő kezelése kiemelt jelentőségű. A csökkent ejekciós frakcióval járó szívelégtelenség (heart failure with re - duced ejection fraction, HFrEF) esetében számos bizonyíték áll rendelkezésre a prognózis javítására, beleértve a halálozás, a hirtelen szívhalál és a szívelégtelenség miatti hospitalizáció csökkentését. Nagy, véletlenszerű betegbevonásos klinikai vizsgálatokban bizonyították be, hogy az angiotenzinkonvertálóenzim-gátlók (ACE-gátlók), az angiotenzinreceptor/neprilysin inhibitor (ARNI) β-blokkolók, a mineralokortikoidreceptor-antagonisták (MRA-k) és a 2-es típusú nátriumglükóz -kotranszporter-2-gátló (SGLT2-gátlók) csökkentik a morbiditást és a mortalitást HFrEF-ben szenvedő betegekben. Ennek megfelelően az Európai Kardiológus Társaság (ESC) 2021- ben megjelent ajánlásában a HFrEF bázisterápiája négy pillérből áll: ACEI/ARNI, BB, MRA és SGLT-2-gátlók. A korábbi, lépcsőzetes terápia felépítés helyett az új ajánlás a négy gyógyszercsoport együttes elkezdését és a céldózisra történő gyors feltitrálását javasolja. A STRONG-HF klinikai vizsgálat a gyorstitrálás és a hagyományos titrálási stratégia összehasonlítására irányult. A vizsgálat eredményei alapján szignifikánsan előnyösebb volt a gyorstitrálás a 180 napon belüli szívelégtelenség miatti rehospitalizációt és az összhalálozást magába foglaló primer összetett végpont, az életminőség változása, valamint a szívelégtelenség miatti rehospitalizáció önálló végpontja tekintetében. A terápiaoptimalizálásnál figyelemmel kell lennünk a HFrEF-ben szenvedô beteg társbetegségeire is, melyek nehezíthetik a titrálási folyamatot. Az ESC Heart Failure Association által publikált konszenzusdokumentum speciális betegprofilok kialakítását javasolja a társbetegségek és a különböző hemodinamikai paraméterek alapján, majd a különböző betegprofiloknak megfelelően terápiás javaslatot is tesz. Összességében elmondható, hogy a legkevesebb korlátozó tényezővel és kontraindikációval az SGLT2-gátlók rendelkeznek, így kivétel nélkül minden profilban alkalmazhatók – már a kezelés kezdetén.
PERANCANGAN USULAN TATA LETAK FASILITAS PABRIK DI XYZ
Authors: Riadi Sugeng , Hasibuan Rizki
Published: August 2023

A good layout ensures efficient material flow, short material transfer distances and minimal material handling costs so operators can work optimally. To deliver goods to the Shifting Lever line which is 23 meters away and takes 53 seconds and must pass through several departments that should not be related to material handling. The current layout is not good because the distance between the storage room and the production area is too far apart and results in a lot of wasted time delivering goods and even longer waiting times. Activity Relationship Chart (ARC) will be used in planning the linkages between each group of interrelated activities. And combined with the method for the Blocplan Algorithm to calculate the degree of closeness between each department. The total material handling displacement distance is calculated as 48,815 meters per month and 585,780 meters per year and causes a total OMH cost of IDR 12,545,455 per month and IDR 150,545,460 per year. and incur OMH costs of IDR 8,828,413 per month and IDR 105,940,956 per year so that the new layout analysis reduces the material handling mileage by 173,547 meters per year and OMH by IDR 44,604,504 per year, or 29.6% per year.
SISTEM PAKAR PENGENALAN KESEHATAN KESELAMATAN KERJA UNTUK MEMDETEKSI RESIKO BAHAYA KERJA DI PT WASCO ENGGINERING MENGGUNAKAN METODE CERTAITY FACTOR
Authors: Hagler Jimmy , Fajrin Alfannisa Annurrullah
Published: August 2023

PT WACO ENGINERING INDONESIA is one of the major Asian OIL & GAS companies engaged in the fabrication and construction of offshore supporting industrial buildings such as FPSO Topsides Modules, E-Houses, Sub-Stations, Compressor Packages and Process Equipment Integrator Modules, which are in KM 5, Tanjung Uncang – Batam. Which includes thousands of employees, both staff/officer workers and non-staff workers or field workers. Workers as one of the resources that are a supporting factor in advancing a company have the right to welfare, health, and work safety. The large number of workers who have direct contact with production machines, heavy work tools, solid materials such as steel and the surrounding work area has the potential for work accidents that can threaten the health and safety of employees. Thus, it is important for companies to implement a K3 (Occupational Health and Safety) management system to reduce the risk of work accidents. Researchers made this research to minimize occupational risks and hazards and increase workers' awareness of Occupational Health and Safety. In this study, the Certainty Factor method will be applied in the framework of making an expert system application that can process uncertainty data from facts and symptoms by presenting large data and calculation needs. The application of this method is expected to identify work risks and hazards at work area points and increase workers' awareness of the risks and hazards that can befall each worker.
Identification of hub genes and key signaling pathways by weighted gene co-expression network analysis for human aortic stenosis and insufficiency
Authors: Yang Yang , Xiao Bing , Feng Xin , Chen Yue , Wang Qunhui , Fang Jing , Zhou Ping , Wei Xiang , Cheng Lin
Published: August 2023

Background

Human aortic valve stenosis (AS) and insufficiency (AI) are common diseases in aging population. Identifying the molecular regulatory networks of AS and AI is expected to offer novel perspectives for AS and AI treatment.

Methods

Highly correlated modules with the progression of AS and AI were identified by weighted genes co-expression network analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by the clusterProfiler program package. Differentially expressed genes (DEGs) were identified by the DESeqDataSetFromMatrix function of the DESeq2 program package. The protein-protein interaction (PPI) network analyses were implemented using the STRING online tool and visualized with Cytoscape software. The DEGs in AS and AI groups were overlapped with the top 30 genes with highest connectivity to screen out ten hub genes. The ten hub genes were verified by analyzing the data in high throughput RNA-sequencing dataset and real-time PCR assay using AS and AI aortic valve samples.

Results

By WGCNA algorithm, 302 highly correlated genes with the degree of AS, degree of AI, and heart failure were identified from highly correlated modules. GO analyses showed that highly correlated genes had close relationship with collagen fibril organization, extracellular matrix organization and extracellular structure organization. KEGG analyses also manifested that protein digestion and absorption, and glutathione metabolism were probably involved in AS and AI pathological courses. Moreover, DEGs were picked out for 302 highly correlated genes in AS and AI groups relative to the normal control group. The PPI network analyses indicated the connectivity among these highly correlated genes. Finally, ten hub genes (CD74, COL1A1, TXNRD1, CCND1, COL5A1, SERPINH1, BCL6, ITGA10, FOS, and JUNB) in AS and AI were found out and verified.

Conclusion

Our study may provide the underlying molecular targets for the mechanism research, diagnosis, and treatment of AS and AI in the future.
Tracking-related experiences of second-generation Asian Indian students in the USA
Authors: Banerjee Dina , Bhattacharya Akshaj Dev
Published: August 2023

Introduction

While tracking is a powerful determinant of educational inequality, scholarship pays little attention to tracking-related experiences. Tracking-related experiences of students reveal their challenges and coping mechanisms. Consequently, one learns the fundamentals of the agency. This study focuses on tracking the experiences of second-generation Asian Indian students in the USA. Between educational and economic success and discrimination, Asian Indians constitute an interesting population to study tracking.

Methods

Data are derived from 177 in-depth interviews with participants from four sample points. And they are analyzed qualitatively using the grounded theory method.

Results

Tracking-related experiences of second-generation Asian Indian students are characterized by a challenge that reflects discrimination featuring the Indian identity.

Discussion

This study extends the theories on educational inequality and racial microaggression.
Familial and genetic association with neurodevelopmental disorders caused by a heterozygous variant in the SRRM2 gene
Authors: Zhang Tao , Xu Lei , Zhu Hongdan , Ying Yuyi , Ding Jinlong , Ding Haigang , Shi Xiaoliang , He Yao , Jin Xin , Xia Guiyu
Published: August 2023

Background

Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development and function, characterized by an inability to reach cognitive, emotional, and motor developmental milestones. The pathology of NDDs is complex. A recent study found that variants in the SRRM2 gene cause NDDs. However, genetic conditions play the most important role in the etiology of NDD. The genetic causes of NDD are extremely heterogeneous, leading to certain challenges in clinical diagnosis.

Methods

A pregnant woman with congenital intelligence disorder came to our hospital for genetic diagnosis to predict the status of her fetus. Her mother and a brother also suffer from congenital intelligence disorder. She has a daughter with speech delay. Whole exome sequencing was used to identify a mutation (c.1415C>G) in the SRRM2 gene of this family that resulted in a change in the 472nd amino acid residue of the SRRM2 protein from serine to terminated.

Conclusion

We report a family with an autosomal dominant genetic disorder caused by variants in the SRRM2 gene causing NDDs. Prenatal diagnosis can help patients with this genetic disorder to have healthy offspring.
Characteristics of immunotherapy trials for nasopharyngeal carcinoma over a 15-year period
Authors: Huang Huageng , Yao Yuyi , Deng Xinyi , Weng Huawei , Chen Zegeng , Yu Le , Wang Zhao , Fang Xiaojie , Hong Huangming , Huang He , Lin Tongyu
Published: August 2023

Background

Immunotherapy has been a hotspot in nasopharyngeal carcinoma (NPC) in recent years. This study aimed to provide a comprehensive landscape of the characteristics of immunotherapy clinical trials in NPC and to determine whether contemporary studies are of sufficient quality to demonstrate therapeutic value.

Methods

This is a cross-sectional analysis of NPC trials registered on ClinicalTrials.gov in the last 15 years (Jan 1, 2008-Nov 20, 2022). Only interventional trials with a primary purpose of treatment were included in the final analysis. Characteristics of immunotherapy trials were compared with those of other NPC trials. Chronological shifts in NPC immunotherapy trials were also analyzed.

Results

Of the 440 NPC studies selected, 161 (36.6%) were immunotherapy trials and 279 (63.4%) were other NPC trials. NPC immunotherapy trials were more likely than other NPC trials to be phase 1-2 (82.6% vs. 66.7%, P < 0.001), single-arm (51.3% vs. 39.6%, P = 0.020), non-randomized (64.8% vs. 44.4%, P < 0.001), and enroll fewer than 50 participants (46.3% vs. 34.4%, P = 0.015). Blinding was used in 8.8% of NPC immunotherapy trials. Also, 90.7% of NPC immunotherapy trials were recruited nationally and 82.6% were Asia-centric. Although academic institutions and governments (72.7%) were the major sponsors of NPC trials, immunotherapy trials were more likely to be industry-funded than other NPC trials (34.2% vs. 11.5%, P < 0.001). The number of NPC immunotherapy trials increased exponentially after 2017, attributed to the exploration of immune checkpoint inhibitors. Immunotherapy combined with chemotherapy was the most commonly investigated regimen.

Conclusion

NPC immunotherapy trials over a 15-year period were predominantly exploratory. To generate high-quality evidence and advance the clinical application of immunotherapy in NPC, more attention and concerted efforts are needed.
Fc multimers effectively treat murine models of multiple sclerosis
Authors: Wang Jin , Brown Kellie , Danehy Caroline , Mérigeon Emmanuel , Goralski Stephen , Rice Samuel , Torgbe Kwame , Thomas Fridtjof , Block David , Olsen Henrik , Strome Scott E. , Fitzpatrick Elizabeth A.
Published: August 2023

Multiple Sclerosis (MS) is a chronic neurodegenerative disease with limited therapeutic options. Recombinant Fc multimers (rFc), designed to mirror many of the anti-inflammatory activities of Intravenous Immunoglobulin (IVIG), have been shown to effectively treat numerous immune-mediated diseases in rodents. In this study we used the experimental autoimmune encephalomyelitis (EAE) murine model of MS to test the efficacy of a rFc, M019, that consists of multimers of the Fc portion of IgG2, in inhibiting disease severity. We show that M019 effectively reduced clinical symptoms when given either pre- or post-symptom onset compared to vehicle treated EAE induced mice. M019 was effective in reducing symptoms in both SJL model of relapsing remitting MS as well as the B6 model of chronic disease. M019 binds to FcγR bearing-monocytes both in vivo and in vitro and prevented immune cell infiltration into the CNS of treated mice. The lack of T cell infiltration into the spinal cord was not due to a decrease in T cell priming; there was an equivalent frequency of Th17 cells in the spleens of M019 and vehicle treated EAE induced mice. Surprisingly, there was an increase in chemokines in the sera but not in the CNS of M019 treated mice compared to vehicle treated animals. We postulate that M019 interacts with a FcγR rich monocyte intermediary to prevent T cell migration into the CNS and demyelination.
A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells
Authors: Joo Victor , Petrovas Constantinos , de Leval Laurence , Noto Alessandra , Obeid Michel , Fenwick Craig , Pantaleo Giuseppe
Published: August 2023

Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion. Blockade of PD-1 interaction with its ligands PD-L1 and PD-L2 is an important determinant in promoting the functional recovery of exhausted T cells. Here, we show that anti-PD-1 mAbs act through an alternative mechanism leading to the downregulation of PD-1 surface expression on memory CD4+ and CD8+ T cells. PD-1 receptor downregulation is a distinct process from receptor endocytosis and occurs in a CD14+ monocyte dependent manner with the CD64/Fcγ receptor I acting as the primary factor for this T cell extrinsic process. Importantly, downregulation of surface PD-1 strongly enhances antigen-specific functional recovery of exhausted PD-1+CD8+ T cells. Our study demonstrates a novel mechanism for reducing cell surface levels of PD-1 and limiting the inhibitory targeting by PD-L1/2 and thereby enhancing the efficacy of anti-PD-1 Ab in restoring T cell functionality.
Molecular bioinformatic and functional analysis of Enolase4 gene during siphonal autotomy and regeneration of razor clam Solen grandis
Authors: Zhang Zhidong , Sun Xuefeng , Chen Aihua , Yang Jiaxin , Chen Suhua , Zhang Yu , Cao Yi , Peng Yuheng , Zhu Yanqing , Wu Yangping
Published: August 2023

For the razor clam Solen grandis, siphonal autotomy and regeneration is a necessary means of facing external stress, which is accompanied by a large amount of energy consumption. To explore the function of the ENO4 gene in the siphonal autotomy and regeneration of S. grandis, the full-length cDNA of the ENO4 in S. grandis was cloned and characterized. The full-length cDNA of SgENO4 was 2,773 base pairs (bp), with an 1,851 bp coding sequence (CDS) encoding 616 amino acids. ​Bioinformatic analysis revealed a slightly lower codon usage bias and a relatively stable nucleotide composition in the SgENO4 sequence. Three conserved motifs were found from the SgENO4 sequence. These conserved motifs vary in length from 14 to 27 amino acids. Moreover, in the siphonal pre-autotomy of razor clams, expression level of the SgENO4 gene was significantly higher in the hepatopancreas and siphonal base than other tissues (P < 0.05). However, the expression of the SgENO4 gene in the siphonal base decreased significantly in the siphonal post-autotomy 7 hours and gradually recovered as the regeneration process continued. ​Linear correlation analysis showed that there was a significant linear correlation between specific weight of siphon and relative expression levels of SgENO4 (R2 = 0.826). RNA interference (RNAi) result showed that the specific weight (the proportion of siphonal weight to body weight) is significantly lower than other groups on the seventh day (P < 0.05), suggesting that interfering with the expression of the SgENO4 gene could inhibit the siphonal regeneration of S. grandis. These results further demonstrate that SgENO4 is a conserved sequence and that it plays a crucial role in the siphonal autotomy and regeneration of S. grandis, advancing further understanding in exploring molecular mechanisms in the siphonal autotomy and regeneration.
Patency testing improves capsule retention rates but at what cost? A retrospective look at patency testing
Authors: O'Hara Fintan , Walker Caroline , McNamara Deirdre
Published: August 2023

Capsule retention is one of the major complications of capsule endoscopy, which range from 2.1 to 8.2% depending on the indication. Over the last few years, reported rates of retention have fallen due to better patient selection due to the recognition of risk factors for capsule retention as well as the introduction of the patency capsule. The patency capsule is a dissolvable capsule with the same dimensions as the functional capsule. It breaks down in the GI tract after approximately 30 h, reducing the risk of symptomatic retention. Failure to pass this patency capsule out of the small bowel results in the patient being excluded from capsule endoscopy. We performed a retrospective analysis of the patency capsules performed in our unit over a 12-month period. A total of 166 (14.7%) of 1,127 patients referred for capsule endoscopy were deemed to require patency assessment (45.8% men, mean age 48 years). Of those who passed the patency assessment and underwent capsule endoscopy, no capsule retention was seen. Indication for patency assessment was found to be appropriate in 87.0% (n = 147). Overall, the failure rate at the patency assessment was 43.1%. The patency capsule remains an imperfect but useful tool in examining functional patency of the GI tract prior to capsule endoscopy.