bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAGEMENT OF PREGNANCY, DELIVERY AND POST-NATAL PERIOD IN THE PATIENT WITH DRUG RESISTANT DESTRUCTIVE PULMONARY TUBERCULOSIS AFTER SEVERAL SURGERIES
Authors: Kayukova S. I. , Komissarova O. G. , Karpina N. L. , Romanov V. V. , Uvarova E. V. , Limarova I. V.
Published: July 2018

The article describes a clinical case of the successful management of pregnancy, delivery and post-natal period in the female patient with fibrous cavernous tuberculosis with extensive drug resistance and multiple thoracic surgeries in the past. This clinical case demonstrates that it is possible for a mother with the advanced form of tuberculosis to give birth to a healthy mature newborn.
METHODS OF TUBERCULOSIS DETECTION IN ADOLESCENTS
Authors: Shurygin A. A. , Furina E. V. , Nemyatykh S. M. , Druzhinina E. A.
Published: July 2018

.
Time-reversal symmetry, anomalies, and dualities in (2+1)$d$
Authors: Cordova Clay , Hsin Po-Shen , Seiberg Nathan
Published: July 2018

We study continuum quantum field theories in 2+1 dimensions with
time-reversal symmetry
\cal T.
The standard relation
{\cal T}^2=(-1)^F
is satisfied on all the “perturbative operators” i.e. polynomials in the
fundamental fields and their derivatives. However, we find that it is
often the case that acting on more complicated operators
{\cal T}^2=(-1)^F {\cal M}
with
\cal M
a non-trivial global symmetry. For example, acting on monopole
operators,
\cal M
could be \pm1±1
depending on the magnetic charge. We study in detail
U(1)U(1)
gauge theories with fermions of various charges. Such a modification of
the time-reversal algebra happens when the number of odd charge fermions
is
2 ~{\rm mod }~4,
e.g. in QED with two fermions. Our work also clarifies the dynamics of
QED with fermions of higher charges. In particular, we argue that the
long-distance behavior of QED with a single fermion of charge
22
is a free theory consisting of a Dirac fermion and a decoupled
topological quantum field theory. The extension to an arbitrary even
charge is straightforward. The generalization of these abelian theories
to SO(N)SO(N)
gauge theories with fermions in the vector or in two-index tensor
representations leads to new results and new consistency conditions on
previously suggested scenarios for the dynamics of these theories. Among
these new results is a surprising non-abelian symmetry involving
time-reversal.
International rehabilitation model for oncological patients
Authors: Semiglazova T. Yu. , Klyuge V. A. , Kasparov B. S. , Kondratyeva K. O. , Krutov A. A. , Zernova M. A. , Chulkova V. A. , Semiglazov V. V.
Published: July 2018

Taking into account the multifunctional disorders and consequences of oncological diseases and their treatment, rehabilitation in oncology has many goals and is aimed at restoring the physical, emotional, social, role and cognitive functioning of the patient, as well as returning the patient to previous labor activity. The principles of rehabilitation measures vary considerably from country to country, depending on the social security system in which they are included. In most European countries and in theUnited States of America, rehabilitation activities are mainly carried out on an outpatient basis. Whereas inGermanythere is a unique system in which rehabilitation is performed mainly in a hospital environment. This article presents an overview of rehabilitation measures in oncology practice conducted in different countries.
Breast cancer biomarker (ER, PR, HER2) changes in the phenotype after neoadjuvant treatment
Authors: Bashlyk V. O. , Kudaibergenova A. G. , Artemyeva A. S. , Muravtseva A. L. , Chirsky V. S. , Semiglazova T. Yu. , Klimenko V. V. , Semiglazov V. F.
Published: July 2018

Objective: to study the breast cancer phenotype (ER/PR, FOXA1, HER2, Ki67) and the dynamics of changes in these markers in the tumour before and after neoadjuvant chemotherapy (NAT), compare them with metastases in the regional lymph nodes (LN). Materials and methods. The subject of the study was a group of patients with breast carcinomas receiving NAT according to the TAC and TC regimens, who had metastases in regional LUs in the course of the treatment (urN1,2,3). Results. Patients were divided into three groups. The first group (n = 11, primary tumour and tumour after NAT). The conversion of hormone receptor expression was both upward (37.5%) and downward (62.5%). Expression of HER2 has only changed upward by 36.4%.

The second group (n = 32, residual tumour and regional metastases). The conversion of hormonal receptors was reported in 12.5%. Expression of HER2 has changed by 21.87%. In the third group (n = 11, the primary tumour before the onset of NAT and metastasis in LN after treatment). Conversion of ER in 18.2% in the form of a total loss, PR in 54.5%. Expression of HER2 increased by 45.5%. Expression of FOXA1 remained stable in all cases after NAT, where expression of hormonal receptors decreased or disappeared. Conclusions. In the era of personalized therapy and NAT, it is required to conduct a pathomorphological study of the immunohistochemical status of metastases in LN, since the hormone receptor status changes in almost 20% of cases, with the signal pathway for steroid hormone receptors remaining unchanged. The HER-2 oncoprotein expression status changes in almost half of cases when comparing the primary biopsy and metastasis after NAT.
«Renal masks» of acute leucosis in children
Authors: Ni A. , Shumatova T. A. , Sergeeva E. V. , Prikhodchenko N. G. , Zernova E. S. , Shishatskaya S. N. , Katenkova E. Yu. , Grigoryan L. A. , Chun En I. , Kapelyukh A. V.
Published: July 2018

The article describes the onset of acute lymphoblastic leucosis, which has a mask of kidney pathology in children. The presented cases are characterized by early manifestation of the disease against the absence of classical markers of oncological diseases. The diagnosis was successfully verified only on the basis of immunohistochemical tests. This paper may be of interest for pediatricians, children’s oncologists and hematologists, children’s nephrologists.
Results of the use of ramucirumab in combination with paclitaxel or ramucirumab monotherapy as the second line treatment in patients with disseminated HER2-negative gastric or cardioesophageal junction adenocarcinoma: experience of N.N. Blokhin russian cancer research center of the ministry of health of Russia
Authors: Besova N. S. , Titova T. A. , Trusilova E. V. , Gorbunova V. A. , Tryakin A. A. , Gordeeva O. O. , Rumyantsev A. A. , Nasyrova R. Yu. , Zhukova L. G. , Snegovoy A. V. , Artamonova E. V. , Manzyuk L. V. , Fedenko A. A.
Published: July 2018

Background.Working out of the second line chemotherapy of advanced gastric adenocarcinoma is a promising approach to cancer therapy. Ramucirumab, an anti-angiogenic agent specifically targeting vascular endothelial growth factor receptor-2 (VEGFR-2). In April 2014, the FDA approved ramucirumab as a single agent or in combination with paclitaxel for treatment of advanced gastric or gastroesophageal junction adenocarcinoma that has progressed on or after prior fluoropyrimidineor platinum containing chemotherapy based on data of REGARD and RAINBOW trials.

Materials and Methods: From June 2016 to 15Jan 201837 pts with advanced GC were treated with ramucirumabin the second line treatment as single agent (11 pts) or in combination with paclitaxel (26 pts) in N.N.Blokhin National medical research center of oncology.

Results: edian PFS (MPFS) and median OS (MOS) was 1,8 and 7,6 mons for monotherapy group. For combination group MPFS was 4,0mons, MOS -10,6 mons. Ramucirumab had an acceptable safety profile

Conclusions:ur data are similar to the data of international randomized trials.
A clinical case of 3-year highly efficient pembrolizamable therapy of metasatic lung adenocarcinoma
Authors: Laktionov K. K. , Yudin D. I. , Sarantseva K. A. , Laktionov K. P. , Breder V. V. , Reutova E. V.
Published: July 2018

Immunotherapy presents a new promising approach to the treatment of disseminated lung cancer. Pemriblisumab (Kitruda®) is one of the antiPD-1 drugs registered in Russia, which is used in both the secondand, in the event of high-level PD-L1 expression (≥50%), the first-line therapy. This paper presents a clinical observation of a highly efficient pemribrolizumab treatment of a patient with metastatic adenocarcinoma.
PENURUNAN PARTISIPASI ANAK USIA DINI PADA TAMAN PENDIDIKAN AL-QUR’AN
Authors: Jumiatmoko Jumiatmoko
Published: July 2018

Abstract
This study aims to describe the factors causing the decrease of early child participation in Taman Pendidikan Al Qur’an (TPA) Al Huda and its interaction. This research uses qualitative approach with case study method. This research was conducted at TPA Al Huda Dukuh Tanggung Desa Menjing. The sample of this study was 11 children. Data collection was conducted with in-depth interviews and participant observation. Data were analyzed with interactive model analysis. The results of this research include 1) Factors causing the decline of early childhood participation in TPA Al Huda that is a) They have received Islamic learning in kindergarten, b) They do not get special attention from parents, c) Their siblings do not participate, and ) They get Influence from more mature friends, e) They have different sects, and f) They participate in the new mosque dumping. 2) The interaction of factors causing the decline of early childhood participation in the TPA Al Huda shows that the majority of children are affected by more than one factor. 

Abstrak
Penelitian ini bertujuan mendeskripsikan faktor-faktor yang menyebabkan penuruan partisipasi anak usia dini di Taman Pendidikan Al Qur’an (TPA) Al Huda beserta interaksinya. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Penelitian ini dilaksanakan pada TPA Al Huda Dukuh Tanggung Desa Menjing. Sampel yang digunakan dalam penelitian ini sebanyak 11 anak. Pengumpulan data dilaksanakan dengan wawancara mendalam dan observasi terlibat. Analisis data menggunakan model analisis interaktif. Hasil penelitian ini meliputi 1) Faktor-faktor yang menyebabkan penurunan partisipasi anak usia dini di TPA Al Huda meliputi a) Telah mendapat pembelajaran agama Islam di TK, b) Tidak memperoleh perhatian khusus dari orang tua, c) Kakak kandung tidak berpartisipasi di TPA, d) Pengaruh teman yang lebih dewasa, e) Berbeda aliran/mazhab, dan f) Berpindah ke TPA masjid baru. 2) Interaksi faktor penyebab penuruan partisipasi anak usia dini di TPA Al Huda, menunjukkan bahwa mayoritas anak terdampak lebih dari satu faktor.
PENDIDIKAN BERBASIS MULTIKULTURAL DALAM PELESTARIAN KEBUDAYAAN LOKAL NUSANTARA DI ERA GLOBALISASI
Authors: Suradi Ahmad
Published: July 2018

Abstract
This article analyzes the importance of preserving the local cultural values of the archipelago in addition to facing the negative impacts of social change caused by globalization. The phenomenon that society now faces is a very basic social and cultural change. Acceleration of information wave globalization bring significant changes in society, both at the level of surface structure (attitude and behavior patterns) and deep structure (value system, life view, philosophy and belief). Changes occur because of inter-state cultural contacts that are interpreted by the dialectic of new values with old values that dominate each other, which allows homogenization and neoliberalization in all aspects of life including local cultural values that have been the guidance of society. This condition gives rise to spit and a sense of value because society is more glorifying modern value by marginalizing transcendental value. As a result there are various forms of deviation of moral values that are reflected in the style, style, and lifestyle of society. Therefore, the strengthening and inheritance of local cultural values needs to be done intensively in the younger generation.

Abstrak
Artikel ini menganalisis pentingnya pelestarian nilai-nilai budaya lokal nusantara selain untuk menghadapi berbagai dampak negatif perubahan sosial yang diakibatkan globalisasi. Gejala yang dialami masyarakat kini adalah perubahan sosial budaya yang sangat mendasar. Akselerasi informasi gelombang globalisasi membawa perubahan cukup signifikan pada masyarakat, baik pada tataran surface structure (sikap dan pola-pola perilaku) dan deep structure (sistem nilai, pandangan hidup, filsafat dan keyakinan). Perubahan terjadi karena kontak budaya antar negara yang dimaknai adanya dialektika nilai-nilai baru dengan nilai-nilai lama yang saling mendominasi, yang memungkinkan terjadinya homogenisasi dan neoliberalisasi pada seluruh aspek kehidupan termasuk nilai-nilai budaya lokal yang selama ini menjadi pegangan masyarakat. Kondisi ini menimbulkan spit dan kegamangan nilai karena masyarakat lebih mengagungkan nilai modern dengan memarginalkan nilai transcendental. Akibatnya terjadi berbagai bentuk penyimpangan nilai moral yang tercermin dalam corak, gaya, dan pola hidup masyarakat. Oleh karenanya penguatan dan pewarisan nilai-nilai budaya lokal perlu dilakukan secara intensif pada generasi muda.
Risk analysis in the process of new equipment introduction into production
Authors: Andreev Sergei Sergeevich , Samarin Yurij Nikolaevich
Published: July 2018

The risks analysis in the process of new equipment introduction into production is studied in this article. The authors come to the conclusion that it is necessary to develop techniques for the introduction of multifunctional process equipment at individual enterprises with the subsequent introduction of them in all industries of Russian industry.
Legal regulation of the rights and duties of spouses in the legislation of the Russian Federation and developed countries in the foreign legal order
Authors: Tolenova Anzhela Olegovna
Published: July 2018

The author in this article describes the rights and duties of spouses according to Russian legislation. It is noted, when absolute freedom of action is meant, and when the spouses must fulfill their duties. The characteristics of legal relations between spouses in foreign law is given.
Quality as an economic category and management object
Authors: Vizzhachaya Aleksandra Aleksandrovna
Published: July 2018

Problems of quality of market economy are revealed, the main approaches to determination of category «quality» and levels of his assessment under to the ISO international standards of a series 9000 are considered in the article. The interrelation of economy and quality management, efficiency and quality of performance of production is disclosed, considering foreign and domestic experience. The main problem of quality which major factor is increase in the standard of living, economic, social and ecological security is considered.
Disadvantages of rules of regulation of transfer pricing in the Russian Federation and ways of their improvement
Authors: Fedosova Olga Alexandrovna
Published: July 2018

Transfer pricing is an effective way to rise a competitiveness of vertical integrated companies and global value chains. This article considers advantages and shortcomings in the regulation of transfer pricing in Russia, describes examples, which show that tax authorities are not interested in cooperation with companies. There are some methods for improving tax legislation.
To the question of carrying out the chamber tax check before the legislation settled
Authors: Khusainova Anastasia Valeryevna
Published: July 2018

This article is devoted to the classification and analysis of the deadline for carrying out a desk tax audit, taking into account the current legislation and judicial practice. The work considers different points of view regarding the concept of "in-office tax audit".
The formation and development of the North American model of judicial constitutional control
Authors: Khusainova Anastasia Valeryevna
Published: July 2018

This article is devoted to the historical aspect of the formation and development of the North American model of judicial constitutional review. The author comes to the conclusion that this model does not create an independent branch of the judicial system, therefore, constitutional control implementation recognizes the integrity of the entire judicial apparatus.
Silver Nanomaterials in Contemporary Molecular Physiology Research
Authors: Pantic Igor , Sarenac David , Cetkovic Mila , Milisavljevic Milan , Rakocevic Rastko , Kasas Sandor
Published: July 2018

Silver nanoparticles have numerous potential applications in engineering, industry, biology and medicine. Because of their unique chemical properties, they have become the focus of many research teams all over the world. Silver nanoparticles may exhibit significant antimicrobial and anticancer effects, and they may be a valuable part of various bioassays and biosensors. However, the research on biological and medical uses of AgNPs is related with numerous potential problems and challenges that need to be overcome in the years ahead. Possible toxic effects of silver nanoparticles on living organisms represent a great concern, both in clinical medicine and public health. Nevertheless, in the future, it may be expected that all metallic nanomaterials, including the ones made from silver will greatly benefit almost all natural scientific fields. In this short review, we focus on the recent research on silver nanoparticles in experimental physiology, as well as other areas of fundamental and clinical medicine.
Carbohydrates: Potential Sweet Tools Against Cancer
Authors: Franconetti Antonio , López Óscar , Fernandez-Bolanos José G.
Published: July 2018

:

Cancer, one of the most devastating degenerative diseases nowadays, is one of the main targets in Medicinal Chemistry and Pharmaceutical industry. Due to the significant increase in the incidence of cancer within world population, together with the complexity of such disease, featured with a multifactorial nature, access to new drugs targeting different biological targets connected to cancer is highly necessary.

:

Among the vast arsenal of compounds exhibiting antitumor activities, this review will cover the use of carbohydrate derivatives as privileged scaffolds. Their hydrophilic nature, together with their capacity of establishing selective interactions with biological receptors located on cell surface, involved in cell-to-cell communication processes, has allowed the development of an ample number of new templates useful in cancer treatment.

:

Their intrinsic water solubility has allowed their use as of pro-drug carriers for accessing more efficiently the pharmaceutical targets. The preparation of glycoconjugates in which the carbohydrate is tethered to a pharmacophore has also allowed a better permeation of the drug through cellular membranes, in which selective interactions with the carbohydrate motifs are involved. In this context, the design of multivalent structures (e.g. gold nanoparticles) has been demonstrated to enhance crucial interactions with biological receptors like lectins, glycoproteins that can be involved in cancer progression.

:

Moreover, the modification of the carbohydrate structural motif, by incorporation of metal complexes, or by replacing their endocyclic oxygen, or carbon atoms with heteroatoms has led to new antitumor agents.

:

Such diversity of sugar-based templates with relevant antitumor activity will be covered in this review.
Semi-dynamic Control of FCM Initialization for Automatic Extraction of Inflamed Appendix from Ultrasonography
Authors: Kim Kwang Baek , Park Hyun Jun , Song Doo Heon
Published: July 2018

Background:

Current naked-eye examination of the ultrasound images for inflamed appendix
has limitations due to its intrinsic operator subjectivity problem.

Objective:

In this paper, we propose a fully automatic intelligent method for extracting inflamed
appendix from ultrasound images. Accurate and automatic extraction of inflamed appendix from
ultrasonography is a major decision making resource of the diagnosis and management of suspected
appendicitis.

Methods:

The proposed method uses Fuzzy C-means learning algorithm in pixel clustering with
semi-dynamic control of initializing the number of clusters based on the intensity contrast dispersion
of the input image. Thirty percent of the prepared ultrasonography samples are classified into
four different groups based on their intensity contrast distribution and then different number of clusters
are assigned to the images in accordance with such groups in Fuzzy C-means learning process.

Results:

In the experiment, the proposed system successfully extracts the target without human intervention
in 82 of 85 cases (96.47% accuracy). The proposed method also shows that it can cover
the false negative cases occurred previously that used self-organizing map as the learning engine.

Conclusion:

Such high level reliable correct extraction of inflamed appendix encourages to use the
automatic extraction software in the diagnosis procedure of suspected acute appendicitis.
Azadirachta Indica and Brassica Oleracea Mediated Green Synthesis vs. Chemical Synthesis of Silver Nanoparticles and their Antibacterial Properties
Authors: Sharma R. , Singh J. , Bhatia A.K.
Published: July 2018

Introduction:

An alternative source of synythesis of nanoparticles is plant extract rather than
chemical methods. This is because of presence of secondary metabolites or reducing agents in plant extract
which are responsible for nanoparticles synthesis. In bioaccumulation, this synthesis depends upon
the availability of particular enzymes or protein in plant extract.

Materials & Methods:

Considering the therapeutic potentials of nanoparticles, this work has been designed
to find out antibacterial activity of silver nanoparticles. Objectives of this work are - preparation
of silver nanoparticles chemically and biologically, characterisation of nanoparticles and evaluation of
their antibacterial activities against E. coli. Comparision of antibacterial properties were made among
NaBH4- AgNPs, Azadirachta indica (Neem) extract AgNPs and Brassica oleracea (Cauliflower) extract
AgNPs. UV- absorption spectra of chemically and biologically synthesized AgNPs at different time intervals
were measured using UV-Visible spectrophotometer. Particle size of AgNPs was measured by
dynamic laser scattering technique (DLS) using Malvern Aimil Zetasizer.

Results:

The obtained silver nanoparticles were of sizes between 10 nm and 100 nm.

Conclusion:

It was clear from antibacterial activities that biologically synthesized AgNPs were more
effective against E. coli than chemically synthesized AgNPs.
Transformed Double-Capped Gold Nanorods in Dye Co-Sensitized Solar Cells for Semitransparent Windows
Authors: Mazzoni Marina , Dagar Janardan , Lai Sarah , Centi Sonia , Ratto Fulvio , Pini Roberto , Zani Lorenzo
Published: July 2018

Background:

Dye sensitized solar cells (DSSCs) containing two different dyes were recently used for
applications to windows. To enhance the efficiency of this type of solar cells by means of the effect of localized
surface plasmon resonance (LSPR), we produced gold nanorods (GNRs) with an aspect ratio (a.r.) equal to 3:1
and tos 4:1. With an actual window application in mind, and mainly to prevent corrosion by the redox mediator in
the cell, we considered the capping of GNRs before introducing them into the titanium oxide (TiO2) layer of the
anode. In particular, we made a double-capping with silica and titania layers for a limited total thickness (i.e.,
about 6 nm), while still allowing a significant localized LSPR effect despite the increased distance between gold
and dye molecules. We documented the different transformations in dimensions of the two types of capped gold
nanorods (c-GNRs) due to the effect of sintering. Our aim was to evaluate the influence that these transformations
would have on the photovoltaic performances of DSSCs.

Methods:

We added c-GNRs with a ratio of 2% in w/w to a transparent semiconductor paste, which was doctor
bladed on the photoanodes of the co-sensitized solar cells made with commercially available organic sensitizers
(L1 or L0) and the squaraine SQ2, which acted as a co-sensitizer. The films had a thickness of about 6 μm and
were sintered at 450°C. We used transmission electron microscopy (TEM) analysis to document the transformations,
absorbance and absorptance spectra in order to control the effects of these modifications, and transmittance
spectra for evaluating the see-through effects. We performed current-voltage, external quantum efficiency
(EQE%) and electrochemical impedance spectroscopy (EIS) characterizations of the DSSCs.

Results:

The semiconductor films with c-GNRs that had GNRs with an a.r. equal to 4:1 (c-GNRs 4:1) had lower
absorption and higher transmission as compared to those with GNRs a.r equal to 3:1 (c-GNRs 3:1). Only the c-
GNRs 3:1, which retained a similar shape and an a.r. equal to 1.5 after sintering, produced an enhancement in the
power conversion efficiency η% (23%), current Jsc (8%), and voltage Voc (2.5%) when used in combination with
the dye cocktail containing the organic dye L1. On the contrary, the presence of c-GNRs 4:1 negatively influenced
the photovoltaic performances of the cells containing this dye cocktail. The same occurred for both types of
c-GNRs with the dye cocktail containing L0.

Conclusion:

The use of c-GNRs 3:1 could actually improve the efficiency of co-sensitized DSSCs. On the other
hand, the transformed dimensions of the c-GNRs 4:1 negatively influenced the photovoltaic characteristics when
we used the same concentration of nanoparticles, and a semiconductor paste in small grains (i.e., about 20 nm).
We attributed this fact both to a reduced penetration of the dyes in the films and to an inferior plasmonic effect.
Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines
Authors: Ramos Priscila M.M. , Pezuk Julia A. , Castro-Gamero Angel M. , Oliveira Harley F. , Scrideli Carlos A. , Umezawa Kazuo , Tone Luiz G.
Published: July 2018

Background:

NF-κB is a transcription factor involved in the transcriptional regulation of a large number
of genes related to tumorigenesis in several cancer cell types, and its inhibition has been related to anticancer effect.
DHMEQ (Dehydroxymethylepoxyquinomicin) is a compound that blocks the translocation of NF-κB from the
cytoplasm to the nucleus, thus inhibiting its activity as a transcriptional activator. Several studies have shown the
antineoplastic effects of DHMEQ in numerous tumor types, however, there are no surveys that tested their effects in
MB.

Objectives:

The aim of the present study was to evaluate the effects of DHMEQ as NF-κB inhibitor in pediatric MB
cell lines.

Method:

We used the UW402, UW473 and ONS-76 medulloblastoma (MB) cell lines to verify the effect of
DHMEQ on proliferation, clonogenic capacity, apoptosis, cell invasion and migration, and evaluated the effect of the
combination with other drugs and the potential as a radiosensitizator.

Results:

A significant decrease in the cell growth, a strong inhibition of the clonogenic capacity, migration and cell
invasion was observed after NF-κB inhibition in the three MB cell lines. Conversely, increased level of apoptosis
rates were demonstrated. Additionally, treatments with DHMEQ combined with other chemotherapeutic agents were
synergic in most points, and a strong radiosensitization by this compound was observed in the three MB cell lines.

Conclusion:

DHMEQ has potential antitumor effect on MB cells, and it may be considered a new therapeutic agent
to improve treatment approaches in MB.
Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2-Thioxoimidazolidinones
Authors: Abdellatif Khaled R.A. , Elbadawi Mostafa M. , Elsaady Mohammed T. , Abd El-Hafeez Amer A. , Fujimura Takashi , Kawamoto Seiji , Khodair Ahmed I.
Published: July 2018

Background:

Some 2-thioxoimidazolidinones have been reported as anti-prostate and anti-breast cancer
agents through their inhibitory activity on topoisomerase I that is considered as a potential chemotherapeutic target.

Objective:

A new series of 3,5-disubstituted-2-thioxoimidazolidinone derivatives 10a-f and their S-methyl analogs
11a-f were designed, synthesized and evaluated for cytotoxicity against human prostate cancer cell line (PC-3),
human breast cancer cell line (MCF-7) and non-cancerous human lung fibroblast cell line (WI-38).

Results and Method: While compounds 10a-f showed a broad range of activities against PC-3 and MCF-7 cell lines
(IC50 = 34.0 – 186.9 and 24.6 – 147.5 µM respectively), the S-methyl analogs 11a-f showed (IC50 = 22.7 – 198.5 and
16.9 – 188.2 µM respectively) in comparison with 5-fluorouracil (IC50 = 60.7 and 40.7 µM respectively). 11c (IC50 =
22.7 and 29.2 µM) and 11f (IC50 = 28.7 and 16.9 µM) were the most potent among all compounds against both PC-3
and MCF-7 respectively with no cytotoxicity against WI-38.

Conclusion:

The newly synthesized compounds showed good activity against PC-3 and MCF-7 cell lines in
comparison with 5-fluorouracil. Compounds 11c and 11f bound with human topoisomerase I similar to its known
inhibitors and significantly inhibited its DNA relaxation activity in a dose dependent manner which may rationalize
their molecular mechanism as cytotoxic agents.
Effects of Highly Active Antiretroviral Therapy on Renal Function and Renal Phosphate Handling in African Adults with Advanced HIV and CKD
Authors: Adedeji Tewogbade A. , Adebisi Simeon A. , Adedeji Nife O. , Biliaminu Sikiru A. , Olanrewaju Timothy O.
Published: July 2018

Background:

Highly Active Antiretroviral Therapy (HAART) has been implicated in renal dysfunction with hypophosphataemia.

Objective:

We prospectively evaluated renal phosphate excretion during HAART use.

Method:

Newly diagnosed human immunodeficiency virus (HIV)-infected individuals were treated with Tenofovir disoproxil fumarate/Emtricitabine/Efavirenz (TDF/FTC/EFV), n=33; Zidovudine/Lamivudine/Nevirapine (ZDV/3TC/NVP), n=53; and Zidovudine/Lamivudine/Efavirenz (ZDV/3TC/EFV), n=16. Creatinine and phosphate were assayed in blood and urine simultaneously at baseline, 1, 3, 6 and 9 months. Glomerular filtration rate (eGFR), fractional phosphate excretion and reabsorption (FEPi % and TRP), and the ratio of tubular maximum reabsorption of phosphate (TmP) to GFR (TmP/GFR) were estimated.

Results:

At baseline, eGFR showed moderate chronic kidney disease (mean: 35.50 ± 2.02, 33.14 ± 1.63, and 39.97±1.84 ml/min/1.73m2 in the 3 groups respectively); 54 (52.9%) patients had hyperphosphataemia (1.4mmo/L); 43 (42.2%) had normophosphataemia (0.6-1.4mmol/L); 5 (4.9%) had hypophosphataemia (<0.6mmol/L). eGFR improved significantly from 1 month (≥60, 58.65 ± 1.11, and 51.76 ±1.59 ml/min/1.73m2; p=0.04, <0.001, 0.67 respectively), with a relapse at 9 months in TDFtreated subjects (50.10 ± 1.89 ml/min/1.73m2). TDF/FTC/EFV resulted in< significantly greater reduction in plasma phosphate than ZDV/3TC/NVP (p=0.031), but not significantly different from ZDV/3TC/EFV (p=0.968). Similarly, ZDV/3TC/EFV resulted in significantly greater reduction in plasma phosphate than ZDV/3TC/NVP (p=0.036).

FEP% progressively increased with HAART duration, more in TDF-treated and ZDV/3TC/EFV-treated groups than ZDV/3TC/NVP (p=0.014); TRP was elevated (<0.86), implying non-maximal phosphate reabsorption. TmP/GFR values were elevated, (<1.35mmol/l).

Conclusion:

HIV causes kidney dysfunction with reduced phosphate excretion resulting in hyperphosphataemia but HAART improves renal function. Prolonged use of TDF can cause renal toxicity with hypophosphataemia as fractional excretion progressively increased with duration of therapy unlike ZDV/3TC/NVP. The use of different third agents (either NVP or EFV) in zidovudine-based therapy results in significantly different plasma phosphate levels; ZDV/3TC/EFV, like TDF/FTC/EFV, resulted in significantly greater decline in plasma phosphate than ZDV/3TC/NVP. Thus, Evafirenz (EVF) may have similar or synergistic adverse effects with tenofovir disoproxil fumarate (TDF).
Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy
Authors: Okumura Naoki , Hayashi Ryousuke , Koizumi Noriko
Published: July 2018

Background:

Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive disease that affects the corneal endothelium in both eyes. Recent studies have identified a novel genetic basis for FECD, and basic research findings have provided evidence for its underlying pathophysiology. Since its first description by Ernst Fuchs in 1910, the only therapeutic choice has been corneal transplantation using donor corneas. However, accumulating evidence suggests that a change in this “rule” may be imminent.

Conclusions:

This article reviews the current knowledge of the genetics and pathophysiology of FECD, and it introduces some potent therapeutic modalities that show promise as new treatments for this disorder.
Review of Corneal Biomechanical Properties Following LASIK and SMILE for Myopia and Myopic Astigmatism
Authors: Damgaard Iben Bach , Reffat Mohamed , Hjortdal Jesper
Published: July 2018

Worldwide, femtosecond Laser AssistedIn-situKeratomileusis (LASIK) is a well known and commonly used refractive technique, although Small Incision Lenticule Extraction (SMILE) has become increasingly popular since it was introduced in 2011. In LASIK, a corneal flap is cut with a microkeratome or femtosecond laser, followed by thinning of the stromal bed with excimer laser ablation. In SMILE, a minor intrastromal lenticule is cut with a femtosecond laser and subsequently removed through a small incision, leaving the anterior and strongest part of the cornea almost intact. Both LASIK and SMILE require cutting of corneal lamellae that may reduce the biomechanical stability of the cornea, with the potential risk of corneal iatrogenic ectasia as a severe complication. However, SMILE preserves the anterior corneal integrity and may, in theory, better preserve the corneal biomechanical strength than LASIK after surgery.

A review aimed to examine the current literature that describes and compares the corneal biomechanical properties after Laser AssistedIn-situKeratomileusis (LASIK) and Small Incision Lenticule Extraction (SMILE). A comprehensive search was performed in Pubmed.gov using the following search queries: Corneal biomechanical properties, corneal biomechanics, ocular response analyser, ocular response analyzer, ORA,ex vivo, in vitro, Corvis, Corvis ST, LASIK, and SMILE.
Editorial
Authors: Pinto Arena Maria do Céu
Published: July 2018

Os Estudos da Paz entre a reflexão estratégica e a tradição crítica
Твердофазные реакции и фазовые превращения в наноразмерной пленочной структуре висмут/селен
Authors: Когай В.Я. , Михеев Г.М.
Published: July 2018

AbstractExperimental results of a study concerned with solid-phase reactions and phase transformations in a Bi/Se nanoscale film structure under heat treatment in vacuum are presented. Nanocrystalline Bi2Se3, BiSe, and Bi_4Se_3 films are obtained for the first time by solid-phase synthesis at various ratios between the Bi and Se layer thicknesses. The phase-transformation temperatures at which Se, BiSe, and Bi4Se3 crystalline phases are formed are determined. The average crystallite sizes in the Bi_2Se_3, BiSe, and Bi_4Se_3 films are found to be 21, 23, and 33 nm, respectively.
Особенности спектров ЯМР -=SUP=-63,65-=/SUP=-Cu в локальном поле образцов полупроводникового минерала CuFeS-=SUB=-2-=/SUB=- из сульфидных месторождений океана
Authors: Матухин В.Л. , Погорельцев А.И. , Гавриленко А.Н. , Гарькавый С.О. , Шмидт Е.В. , Бабаева С.Ф. , Суханова А.А. , Теруков Е.И.
Published: July 2018

AbstractThe results of studying natural samples of CuFeS_2 chalcopyrite mineral from hydrothermal ore manifestations of island arcs of the Pacific Ocean by ^63Cu nuclear magnetic resonance (^63Cu NMR) in a local field at room temperature are presented. The asymmetric shape of the detected resonance lines in the ^63Cu NMR spectrum indicates the presence of at least two overlapping lines. The presence of two overlapping central components can be a consequence of the occurrence of regions with different types of structural distortion near the resonant nuclei. These results show that the pulsed ^63Cu NMR method can be an effective method for studying the physical properties of deep-sea polymetallic sulfides of the global ocean.
Влияние изотропного давления на вольт-амперную характеристику поверхностно-барьерных диодов Sb-p-Si-Au
Authors: Зайнабидинов С. , Турсунов И.Г. , Химматкулов О.
Published: July 2018

AbstractThe influence of hydrostatic pressure on the current–voltage characteristics of surface-barrier diode structures of the Sb– p -Si〈Mn〉–Au type are investigated. The potential-barrier height and the baric coefficient of its variation are found to be e ϕ_δ = 0.75 eV and δ =–1.54 × 10^–11 eV/Pa, respectively.
Оптическое поглощение поликристаллических слоев сульфида цинка, активированного медью
Authors: Аванесян В.Т. , Ракина А.В. , Каблукова Н.С.
Published: July 2018

AbstractThe characteristics of the optical absorption of copper-activated zinc-sulfide polycrystalline layers after preliminary heat treatment are investigated. The composition of the compound under study was monitored by X-ray fluorescence analysis. The band gap E _ g and characteristic Urbach energy are estimated from the fundamental absorption edge. The contribution of structural defects and the impurity factor to the variation in the optical properties is discussed.
Emission of Cu-=SUB=-2-=/SUB=-O paraexcitons confined by a strain trap: hints of a Bose-Einstein condensate?
Authors: Frohlich D. , Bayer M.
Published: July 2018

AbstractWe monitor the phonon sideband emission from paraexcitons confined in a strain trap in cuprous oxide at T = 1.25 K. On the low energy ank of the optical phonon replicas, both of Γ _5 ^− and Γ _3 ^− symmetry (the latter activated by application of a magnetic field), we detect sharp peaks that might represent indications for a paraexciton Bose–Einstein condensate. In contrast, such peaks are absent in the phonon-mediated emission of the orthoexcitons, and they also disappear at elevated temperatures. The results challenge our understanding of the involved physics, e.g., of the Auger recombination of excitons, which has so far been believed to prevent crossing the border to a condensate.
Двумерные триплетные магнитоэкситоны и магнетофермионный конденсат в GaAs/AlGaAs гетероструктурах
Authors: Кулик Л.В. , Горбунов А.В. , Журавлев А.С. , Тимофеев В.Б. , Кукушкин И.В.
Published: July 2018

AbstractA fundamentally new collective state, namely, the magnetofermionic condensate, is discovered during photoexcitation of a sufficiently dense gas of long-lived triplet cyclotron magnetoexcitons in a twodimensional Hall insulator with a high electron mobility, a filling factor of ν = 2, and temperatures of T < 1 K. The condensed phase coherently interacts with an external electromagnetic field, exhibits superradiant properties in the recombination of correlated condensate electrons with heavy holes in the valence band, and spreads nondissipatively in the layer of a two-dimensional electron gas to macroscopical large distances, transferring an integer spin. The observed effects are explained in terms of a coherent condensate in a nonequilibrium system of two-dimensional fermions with a fully quantized energy spectrum, in which a degenerate ensemble of long-lived triplet magnetoexcitons obeying the Bose statistics is present.
Цепочки наноразмерных диполей в переменных электрических полях
Authors: Фатеев Е.Г.
Published: July 2018

AbstractThe excitability (increase in the number of charges at the poles of nonpoint dipoles) in chains of nanoscale dipoles with varying moments in weak external alternating electric fields (at the level E = 10^–13–10^–4 V/m) at low frequencies Ω < 10^5 Hz has been investigated numerically. It has been found that the level of charge excitations in such systems has a nonlinear dependence with a maximum on the radius (in the range r = 20–200 nm) of nanoscale dipoles. It is concluded that, in these ranges, the probability of self-assembling of single dipoles into the chains is increased.
Резонансное туннелирование электромагнитных волн для увеличения эффективности болометрических фотодетекторов
Authors: Богацкая А.В. , Кленов Н.В. , Терешонок М.В. , Попов А.М.
Published: July 2018

AbstractA method for enhancing the efficiency of bolometric photodetectors is presented. The method utilizes the analogy between the process of tunneling of a flux of quantum particles through a potential barrier and the propagation of electromagnetic waves within a nontransparent medium. The calculation results demonstrate that the fraction of radiation absorbed in a detector at a certain IR frequency may be close to unity if one chooses the right thickness and permittivity of the resonator substrate below a thin metal (superconductor) layer.
Мощностные характеристики и температурная зависимость угловой расходимости излучения лазеров с приповерхностной активной областью
Authors: Жуков А.Е. , Гордеев Н.Ю. , Шерняков Ю.М. , Паюсов А.С. , Серин А.А. , Кулагина М.М. , Минтаиров С.А. , Калюжный Н.А. , Максимов М.В.
Published: July 2018

AbstractResults are presented of a study of light–current characteristics and far-field patterns of emission of stripe lasers with coupled planar waveguides. This configuration makes it possible to suppress the generation of excited modes and to have a small (about 0.9 μm) depth of the active region from the surface of the laser crystal. A high-temperature stability of the angular emission divergence (34.0° ± 1.5°) in the temperature range 20–80°C is demonstrated. The largest value of the output power is limited to 12.2 W in the continuous-wave mode by the catastrophic mirror damage.
Эмиссионная активность при ударном разрушении керамик A-=SUB=-2-=/SUB=-B-=SUB=-6-=/SUB=-
Authors: Щербаков И.П , Дунаев А.A. , Чмель А.Е.
Published: July 2018

AbstractIn this paper, we present results of a study of the generation of electromagnetic emission during impact loading of ZnS and ZnSe ceramics prepared by various techniques. The choice of the type of mechanical action is associated with the typical applications of these ceramics. Separate contributions to emission activity from the dislocations movement and the microcracks development depending on the crystallite size in the ceramics are shown. The electromagnetic emission is compared with parallel time series of pulses of mechanoluminescence and acoustic emission. In all three cases, emission activity was recorded with a time resolution of 10 ns.
Исследование влияния тока плазмы на ионный теплоперенос в сферическом токамаке Глобус-М
Authors: Тельнова А.Ю. , Курскиев Г.С. , Мирошников И.В. , Авдеева Г.Ф. , Бахарев Н.Н. , Гусев В.К. , Минаев В.Б. , Мельник А.Д. , Петров Ю.В. , Сахаров Н.В. , Чернышев Ф.В. , Щёголев П.Б.
Published: July 2018

AbstractExperiments intended to study the dependence of the ion temperature on the plasma current were carried out on the Globus-M spherical tokamak. The ion temperature was measured at a few spatial points with the help of charge exchange spectroscopy and a charge exchange atom analyzer. On the basis of the experimental data, modeling with the use of the ASTRA numerical code was carried out and the thermal diffusivities for the ion plasma component were determined. The calculation results show that the ion behavior is similar to neoclassical.
Влияние переноса заряда в NaAu-=SUB=-y-=/SUB=- на эмиссию ионов
Authors: Кнатько M.В. , Лапушкин М.Н.
Published: July 2018

AbstractWe have studied transient processes of the thermal ionization of sodium on the surface of NaAu_ y semiconductor film under the action of a variable external electric field. It is established that the kinetics of Na^+ ion current during variation of the external field is determined by the establishment of charge distribution in the NaAu_ y film, while the efficiency of thermal ionization of Na atoms is related to the concentration of holes near the NaAu_ y /vacuum interface.
Эффект фотовращения Квинке
Authors: Грачев А.И.
Published: July 2018

AbstractImplementation of the well-known phenomenon of Quincke rotation is proposed, which may be called the “photoinduced Quincke rotation (PIQR) effect.” The PIQR effect is based on the previously discovered phenomenon of rotation of a spherical particle in a stationary electric field under continuous irradiation inducing an electric dipole moment in the particle.
La asignatura "Anatomía Funcional de la Voz". Veinte años de pedagogía de la voz en los estudios de Medicina de la Universidad de Barcelona
Authors: Torres Gallardo Begoña
Published: July 2018

En este trabajo presento la asignatura optativa Anatomía Funcional de la Voz, que imparto en la Facultad de Medicina de la Universidad de Barcelona (España) desde el curso académico 1997/1998. Creé esta asignatura porque consideré que era necesario que los estudiantes de medicina tuvieran un conocimiento profundo de la voz normal para poder así comprender sus trastornos.

La asignatura ha ido sufriendo a lo largo de los años cambios derivados de la entrada de las nuevas tecnologías y de los nuevos métodos docentes en la universidad. En la actualidad consta de nueve sesiones teóricas presenciales y se cierra el con un taller de Técnica Vocal de carácter voluntario.

Los estudiantes realizan tres actividades individuales evaluables a través del Campus Virtual de la Universidad de Barcelona (plataforma Moodle). Las dos primeras son de autoobservación de la postura y de la respiración, y la tercera consiste en la creación de una base de datos de voces, habladas o cantadas (de dominio público). Asimismo, los estudiantes preparan en pequeños grupos un trabajo escrito sobre algún tema relacionado con la voz normal que sea de su interés, que les permite llevar a cabo una revisión y análisis de aspectos concretos de la voz.

Creo que esta asignatura permite a los estudiantes adquirir una visión amplia y multidisciplinar de la voz. Tras haber llegado a su vigésima edición, estoy muy satisfecha de los resultados, no sólo académicos, que siempre son de gran calidad, sino también por la buena acogida que siempre tiene entre el alumnado.
Creación, interpretación y audición. Integración estratégica para el aprendizaje de la armonía en estudiantes de interpretación musical
Authors: Ibáñez Gericke Tania Verónica
Published: July 2018

Nueve estudiantes de interpretación musical pertenecientes al último año de un curso de Solfeo y Práctica Auditiva realizaron la actividad didáctica de crear una pieza musical en pequeños grupos, con el propósito de poner en práctica materias de armonía presentes en el programa de estudios del curso. Orientándose de acuerdo a una pauta de trabajo, elaboraron estas piezas para sus instrumentos de especialidad respectivos. Posteriormente, las creaciones fueron interpretadas por cada grupo al resto del curso, para que estos descubrieran auditivamente los enlaces armónicos utilizados en ellas.

Los estudiantes se mostraron muy motivados al asumir el desafío de crear, actividad poco habitual para la mayoría. Las piezas instrumentales fueron atentamente escuchadas y comentadas por el curso y cada grupo logró describir sus trabajos demostrando dominio teórico sobre la unidad pedagógica en cuestión. En cuanto al reconocimiento auditivo de la armonía utilizada en ellas, los estudiantes lograron muy buenos resultados, pese a que anteriormente la mayoría manifestaba dificultades en esta materia.

En esta comunicación planteo algunas hipótesis surgidas a lo largo del ejercicio de mi docencia, tomando como referencia la experiencia con este grupo de estudiantes, quienes presentaban desempeños inusualmente bajos en la resolución de ejercicios auditivos armónicos. Expongo de manera crítica la forma en que son llevadas a cabo algunas de las actividades didácticas orientadas al desarrollo del oído armónico y propongo algunas ideas para contribuir a mejorar estas prácticas pedagógicas.
CLIMATE CHANGE: Biggest PD Game Ever, Driven by Energy (N = 193)
Authors: Lane Jan-Erik
Published: July 2018

Time is very tight for halting climate change. The COP21 project is not enough, according to the new theory of abrupt climate change. Major meltdowns of ice in Greenland and Antarctica would threaten large coastal cities around the globe, like for instance New York, London and Singapore as well as Shanghai. The discovery of several so-called tipping points substantiates the Hawking warming about irreversibiity.