bluuebunny/crossref_metadata_2025 huggingface dataset:
A STUDY OF THE ROLE PLAYED BY THE POLYMORPHISM OF GENES ENCODING CYTOKINES IN THE DEVELOPMENT OF COMPLICATIONS OF THE UROGENITAL CHLAMYDIA INFECTION IN WOMEN
Authors: Plakhova K I
Published: February 2022

The author describes the results of a study of the polymorphism of genes encoding cytokines IL-6, IL-10, TnF-α, IFN-γ, TGF-β 1 and MBL2 in women suffering from the urogenital chlamydia infection (40 subjects), women with secondary infertility caused by the Chlamydia infection in the medical history (20 subjects) and clinically healthy women of childbearing potential (control group, 20 subjects). The SnapShot multiplex molecular and genetic method was used to study the polymorphism of genes. As a result of the study, the most frequent genotypes were revealed for each polymorphism of cytokine genes. reliable associations (0.01 < р < 0.001) were established between the frequency of individual genotypes (IL6*-174C/C, IL-10*-1082G/A, TGF-β 1*-915G/C, TGF-β 1*-869T/C and MBL2*-204G/G) and the onset of complications of the urogenital chlamydia infection, which makes it possible to exam ine these variants of genotypes as markers of an increased risk for the complicated course of the urogenital chlamydia infection resulting in reproductive disorders in women.
Atypical manifestation of idiopathic atrophoderma of Pasini and Pierini
Authors: Grebennikov V A , Anisimov L A , Gursky G E
Published: February 2022

The authors describe a case of idiopathic atrophoderma of Pasini and Pierini, which was difficult to diagnose, had no clinical signs of skin atrophy and was diagnosed only as a result of histopathology. A female patient aged 25 developed small-size spots of cyanochroic and brown color in the left-hand lumbar area, which formed a focus of irregular shape with the marble pattern without any signs of skin atrophy or compression. Similar foci later affected skin in the area of the left bladebone and left shoulder. However, histopathology revealed atrophic manifestations and a light form of sclerosis in the subepidermal zone of the affected skin, which made it possible to diagnose the condition, and the administered treatment demonstrated positive clinical dynamics.
Clinical experience of using 0.1% mometasone furoate cream for external treatment of steroid-responsive dermatoses
Authors: Statsenko A V , Belousova I E , Khairutdinov V R , Parfenova M A
Published: February 2022

An up-to-date synthetic non-fluorated topical glucocorticosteroid, Histan-N (0.1% mometasone furoate cream), has an evident antiinflammatory, anti-allergic, immune-suppressive and antiproliferative action. Goal. To assess the efficacy, safety and tolerability of Histan-N for the treatment of patients with steroid-responsive dermatoses. Materials and methods. As many as 80 patients with eczema, psoriasis, atopic dermatitis, dermatitis and allergic dermatitis as well as lichen acuminatus underwent treatment. All of the patients received general pathogenetic therapy and external treatment with Histan-N. The treatment efficacy was assessed based on the trends of such dermatological indices as PASI, SCORAD and EASI as well as visual analog scale. Results. Dermatological indices reduced by 70%—90% as compared to the baseline against the background of treatment. Conclusion. The clinical results obtained for Histan-N demonstrate a substantial clinical effect of the drug, absence of adverse effects and high safety of the drug.
Photoprotection in contemporary dermatology and cosmetology: traditional issues and new data
Authors: Aravijskaya E R , Sokolovsky E V
Published: February 2022

The paper contains information of UVB and UVA influence on the various structures of the skin. Main principles of modern photoprotection, sunscreens as well as photoprotective role of clothes are discussed.
Оn the role of pro-fibrous cytokines in the pathogenesis of localized scleroderma
Authors: VOLNUKHIN V A , MURADYAN N L , KATUNINA O R
Published: February 2022

The content and skin distribution of the transforming growth factor β 1 (TGF-β 1), transforming growth factor-β receptor type I receptor (TGF-βRI) and platelet-derived growth factor receptor a (PDGFR-α), which are key fibrosis mediators, were examined in ten patients with localized scleroderma and ten healthy volunteers by using the immunohistochemistry method. A reduced derma concentration of TGF-β 1+ cells (р = 0.007) and increased amount of TGF-βRI+ (р = 0.001) and PDGFR-α+ (р < 0.001) cells was discovered in the patients vs. the control group. Te reduced amount of TGF-β 1 in the affected loci can be apparently explained by its reduced production by cells taking part in the immune inflammation. Increased expression of TGF-βRI receptors (р = 0.001) and PDGFR-α in the foci of localized scleroderma confirms their important role in the pathogenesis of the disease and activation of the fibrosis process in the skin.
Control materials used for diagnostics of syphilis: types and methods for ensuring stability
Authors: Rotanov S V , Frigo N V , Manukiyan T Ye
Published: February 2022

The authors present data about the types of control materials used for diagnostics of serological syphilis, examine problems related to the development of control materials with or without anti-syphilis pathogen antibodies on the basis of the human blood serum. The authors substantiate the advantages of using liquid native control materials as compared to their lyophilic analogs. The article evaluates the effect of a body of physical and chemical factors on the preservation of the specific activity of protein structures in human blood serum samples stored in the native and lyophilic forms. The possibility to use different stabilizers for long-term preservation of the specific activity of antibodies forming a part of control materials is discussed.
Role of the Helicobacter pylori as a trigger factor in the development of rosacea and effect of its eradication on the course of dermatosis
Authors: Slesarenko N A , Leonova M A , Bakulev A L , Davydova A V , Slesarenko N S , Katkova I O
Published: February 2022

The authors conducted an analysis of diseases of the gastrointestinal tract, a study of morphology and functional activity of the mucous coat of different stomach sections, determination of H. pylori, determination of the cytokine profile (anti-inflammatory cytokines) in 55 patients with different forms of rosacea vs. 20 healthy volunteers and 55 patients from the risk group consulted or treated by a gastroenterologist because of gastrointestinal disorders but without any manifestations of dermatosis. Moreover, the authors evaluated the effect of the eradication of H. pylori on the course of the disease and cytokine profile of the immune response in patients suffering from rosacea. It was shown that the group of patients with rosacea have much fewer cases of stomach diseases (gastritis, gastroduodenitis, ulcer) than the group of patients with an increased risk of the development of these diseases. On the contrary, patients with rosacea have more cases of H. pylori (83%) than the group of healthy volunteers (20%) and group of patients with stomach diseases (47%) though the bacterial load is lower (I—II vs. III—IV in the risk group). Indices of the cytokine profile demonstrate that patients with rosacea form an immune response based on the mixed Th1/Th2 response type. This results in the microbial persistence, chronic inflammation and possible autoimmune reactions lasting even after the eradication of H. pylori and improvement of the clinical picture of the disease, which possibly explains the chronic course of the disease and development of recurrences.
A study of the efficacy, safety and tolerance of cosmetic products for basic care and hygiene in a combined therapy of patients suffering from atopic dermatitis in the mild to moderate forms
Authors: Sokolovsky Ye V , Monakhov K N , Lonshakova-Medvedeva A Yu , Arkhipov A V , Parfyonova A A , Moskvin I I , Tsoi A A
Published: February 2022

The article is considering contemporary views on the role and significance of microorganisms in pathogenesis of atopic dermatitis. One can also find here efficiency analysis of cosmetics Emolium P «Triaktivnyj cream» and «Triaktivnaja bath emulsion» as treatments for low and middle severity atopic dermatitis, as well as research results of skin microbiota (before study initiation and on 14 day).
Search for new molecular targets for anticytokine therapy of patients, suffering from the immune dependent skin disease — psoriasis
Authors: KUBANOV A A , FRIGO N V , ROTANOV S V , HAYRULLIN R F , ZNAMENSKAYA L F , SVISHTCHENKO S I
Published: February 2022

The authors describe the results of a study aimed at searching for new molecular targets for anticytokine therapy of patients with psoriasis. The authors examined 26 patients with psoriasis who were treated with such immune biologic substances as infliximab, ustekinumab, adalimumab and 10 healthy volunteers. They performed a quality and quantity analysis of the spectrum of protein molecules of cytokines (L-4, IL-6, IL-17, TNF-α and IL-20, IL-22, IL-31, IL-12, IL-11, IL-18) аs well as VEGF and ICAM-1 molecules in patients receiving the therapy with immune biologic substances before and after treatment using the methodology of the immune enzyme analysis and xMAP multiplex technology. The authors studied the correlation between the level of cytokine expression, on the one hand, and the occurrence and limitation of the disease, on the other hand. The obtained data are sufficient to conclude that the spectrum of molecules of IL6, IL20, IL22 anti-inflammatory cytokines аs well as VEGF and ICAM-1 molecules, for which pathogenic importance in case of psoriasis was revealed as a result of the study , may serve as a potential (new, additional) molecular target for anticytokine therapy of patients suffering with such an immune-dependent skin disease as psoriasis.
Efficiency of application of Aisida cosmeceutical in the external therapy of acne
Authors: SIDORENKO O A , ANISIMOVA L A
Published: February 2022

Possibilities of the modern therapy of acne vulgaris are discussed. The attention is drawn to the fact that in case of the mild and medium disease state the external therapy is emphasized. The role of external antibiotics (clindamycin) and of the azelaic acid was detailed.
Lymphomatoid papulosis
Authors: PLATONOVA A N , BAKULEV A L , SLESARENKO N A , MORRISON A V , SHABOGINA A A , DAVYDOVA A V
Published: February 2022

Etiology, pathogenesis, clinical and pathomorphological criteria of diagnostics of lymphomatoid papulosis are described. The case of own supervision is presented.
Isotretinoine in the treatment of rosacea
Authors: SAMTSOV A V , GORBUNOV Y G
Published: February 2022

Goal: Evaluation of isotretinoine acnecutane) in small doses (0,2 mg/kg/day) in the treatment of papulopustular stage of rosacea. Маterials and methods. 21 patients with papulopustular version of rosacea, not responding to traditional therapeutic methods have been examined. Patients were receiving small doses of isotretinoine acnecutane) (0,2 mg/kg/day). The efficiency of the performed therapy was evaluated with the dermatologic index of life quality. Results. The research has demonstrated the high efficiency of isotretinoine acnecutane) in the treatment of papulopustular stage of rosacea. The use of small doses of the substance allowed to minimize side effects, which can take place at the background of isotretinoine (acnecutane), providing the high safety of it’s application.
Syphilis and gonococcal infection incidence among people from decreed groups of professions and optimization of periodic preventive medical examinations
Authors: KUNGUROV N V , SYRNEVA T A , MAUSHEVSKAYA N P , PAZINA M V
Published: February 2022

The article presents data about the current syphilis and gonococcal infection incidence among people from decreed groups of professions in the territories of Urals, Siberia and Far East. The article generalizes major problems in the field of organization of periodic preventive medical examinations for sexually transmitted infections among people from decreed groups of professions.
Functional characteristics of macrophages in the vitiligo foci
Authors: ZHULMINA V V , KOLOGRIVOVA YE N , PESTEREV P N , LABZOVSKAYA N P
Published: February 2022

Objective. Study of the chemotactic activity of macrophages and local production of cytokines in sterile skin inflammatory exudate in patients with generalized vitiligo (vitiligo vulgaris). Materials and methods. The authors conducted a study of 22 patients with generalized vitiligo and 22 healthy volunteers. The functional activity of macrophages was assessed with the use of the skin window method based on the method of D.N. Mayansky as amended by V.V. Klimov. The composition of sterile cell exudate was examined with the use of impression smears taken after 6 hours from an epidermis scarification section on the healthy and depigmented skin colored according to the Romanovsky-Gimza method with the use of light microscopy. In addition, cytokines were determined in the supernatant fluid of the skin window exudate from the vitiligo focus obtained by means of centrifugation. Results. The prevalence of mononuclear phagocytes over polymorphonuclear leukocytes was revealed in the depigmentation site, which confirms that macrophages take an active part in the disease pathogenesis (along with a high level of interleukin-18). A low level of IL-10 in the skin window exudate confirms that the suppressor effect in the melanocyte damage zone is weak. These results confirm the important role played by such cells of the immune system as phagocytes in vitiligo pathogenesis, which makes it possible to consider them as potential target cells for developing pathogenetically substantiated approaches to the treatment of the disease.
Arndt — Gottron scleromyxedema
Authors: LVOV A N , SHEKLAKOVA M N , MATUSHEVSKAYA YU I , ZNAMENSKAYA L F , SVISHCHENKO S I , KATUNINA O R , CHIKIN V V , YAKOVLEVA A O
Published: February 2022

The authors present a literature review and a case study of a rare form of dermatitis in a female patient aged 44 — Arndt — Gottron scleromyxedema associated with Ig-kappa monoclonal hyper-production. The authors also present the latest information about the etiology and pathogenesis of scleromyxedema and its clinical picture, and discuss the current treatment methods. They also describe a positive effect of a combined therapy with plasmapheresis, methotrexate and prednisolone.
A case of the atypical form of erythema annulare centrifugum in an eight-year-old girl
Authors: YEPIFANOVSKY A I , GREBENYUK V N , GRISHKO T N , BASSE F B , BAKONINA N V , SMOLYANIKOVA V A
Published: February 2022

The authors describe a clinical observation of a case of the atypical form of Erythema Annulare Centrifugum in an eight-year-old girl. They also present literature data concerning the etiology, clinical features and dermatosis differential diagnostics and treatment methods.
Buschke — Ollendorff syndrome in infant patients
Authors: PROSHUTINSKAYA D V , TROFIMCHUK I A , KATUNINA O R , KOCHETKOV M A
Published: February 2022

The authors present a clinical and histological description of two clinical cases of a rare inherited disease, Buschke — Ollendorff syndrome. In both cases, the disease was not accompanied by the bone tissue dysplasia but at the same time it was characterized by a clear histological pattern specific of this syndrome. The authors provide literature data and discuss issues related to the pathogenesis and particular features of the clinical picture and diagnostics of the disease.
Current approaches to diagnostics of mycosis fungoides
Authors: Brattseva E V , Rotanov S V , Bratseva E V , Rotanov S V
Published: February 2022

The authors describe strong and weak sides of current methods for diagnostics of mycosis fungoides.
Diagnostics of mycosis fungoides is mainly based on the clinical presentation of this disease, which is a significant problem for
a dermatovenerologist, especially at early stages of the disease when rashes are of different types. Laboratory methods used to
confirm the diagnosis are microscopic examination and immunophenotypic analysis of skin biopsy samples from the affected
region as well as determination of clonality of T-lymphocytes in the skin using the PCR method.
Neurosyphilis: from the diagnosis to treatment Part i. The epidemiology, pathology and clinic
Authors: RODIKOV M V , PROKHORENKOV V I
Published: February 2022

The modern views a lesion of a nervous system at a syphilis are discussed. Data on epidemiology, pathology and clinical signs of neurosyphilis are cited.
Molecular Markers In Forecasting The Clinical Efficacy Of Infliximab In Psoriasis Patients
Authors: KUBANOVA A A , LESNAYA I N , FRIGO N V , KAGANOVA N L , ZNAMENSKAYA L F , KUBANOV A A
Published: February 2022

Biosamples (skin tissue samples taken from affection foci and blood serum) from 22 patients suffering from severe to medium psoriasis (8 women and 14 men) aged 19-57 treated with Infliximab were analyzed. As for skin tissue samples, the molecular structure of genes TNF-a, TNF-R-I and TNF-R-II, contents of cytokine TNF-a and its soluble receptors (sTNF-RI and sTNF-RII) and proteome composition was analyzed in skin tissue samples; contents of TNF-a, IL2, IL4, IL6, IL-8 and IL-10 were analyzed in the blood serum. The homozygous TT genotype of TNF-R-II gene at the 676 locus and high IL10 level in the blood serum (>2.7 pg/ml) was associated with the high intensity of the psoriasis patient response to treatment with Infliximab; the homozygous GG genotype of TNF-R-II gene at the 676 locus and low level of IL10 in the blood serum (
External glucocorticosteroids: selection criteria in terms ofefficacy and safety
Authors: Belousova T A , Goryachkina M V , Belousova T A , Goryachkina M V
Published: February 2022

The article describes mechanisms of action as well as indications and adverse effects of topical glucocorticosteroids. It examines
the pharmacological and pharmacokinetic properties of fluticasone propionate, an efficient external glucocorticosteroid having a
high safety level and good cosmetic properties. The data of controlled Russian and international studies of the efficacy and safety
of fluticasone propionate for the treatment of psoriasis, atopic dermatitis and eczema.
Results of the study of Cinocap cream clinical efficacy andsafety
Authors: Danilova A A , Kosorukova I M , Danilova A A , Kosorukova I M
Published: February 2022

There was a study of the efficacy and safety of a zinc pyrithione drug, Cinocap® cream, in 40 psoriasis patients. The therapeutic
equivalence of the drug to the original drug, Skin-Cap® cream, was also assessed. Patients aged 18-65 were randomized into
two groups: patients from the first group received a treatment with Cinocap® cream while patients from the second group were
treated with Skin-Cap® cream for 45 days. It was proved that Cinocap® cream is an efficient drug for the treatment of psoriasis and
is comparable to the original drug, Skin-Cap® cream, by its therapeutic effect and safety.
Malignant skin neoplasms: analysis of the incidence rate in the Krasnoyarsk Territory, problems of prevention and improvement of early diagnostics
Authors: RUKSHA T G , GYRYLOVA S N , AKSENENKO M B
Published: February 2022

The authors present the incidence and mortality rates caused by skin cancer in the Krasnoyarsk Territory. They analyze the reasons explaining the growth in the incidence rate for malignant skin neoplasms as well as ways to improve early diagnostics and prevention of skin tumors.
Description of a case of Morbihan disease
Authors: FEDOTOVA M A , SAMCZOV A V , BELOUSOVA I E
Published: February 2022

Abbreviated title of the article: Morbihan disease.
A description of a case of Morbihan disease is presented in the article. This disease is chronic and is characterized by the absence of any specific laboratory and histology changes as well as treatment resistance. Issues of differential diagnostics are discussed. A review of literature is given.
Administering hepatoprotectors for psoriasis: a comparative clinical, laboratory and ultrasonic assessment of its efficacy
Authors: BAKULEV A L , KRAVCHENYA S S
Published: February 2022

There was a comparative study of the clinical efficacy of Heptral® and Essentiale® Forte N in 60 patients suffering from psoriasis. Such indices as psoriatic process severity, quality of life, ultrasonic criteria of psoriasis-mediated skin affection and hepatic function biochemistry were assessed. As a result of the treatment with the use of Heptral®, a distinct and statistically reliable reduction of the psoriasis severity, improvement in the quality of life and normalization of hepatic biochemistry indices were observed. In addition, a reduction in the thickness of epidermis and derma, increase in the ultrasonic density of the latter and more even distribution of the echo signal in all derma layers were recorded in the group taking Heptral® as compared to the group of patients receiving Essentiale® Forte N and control group.
Normative and legal aspects of preventive medical examinations for people of certain professions for sexually transmitted infections and infectious skin diseases
Authors: MINULLIN I K , BILDYUK YE V , VAFiNA G G , GARIFULLINA I V
Published: February 2022

The authors analyze the current regulatory and legal framework defining organization of preventive medical examinations for people of certain professions for sexually transmitted infections and infectious skin diseases. They also describe the experience of organization of preventive medical examinations in the Republic of Tatarstan.
On the role of dendritic cells in the pathogenesis of vitiligo
Authors: Proshutinskaya D V , Volnukhin V A , Katunina O R , Rezaikina A V
Published: February 2022

The authors give the results of immunohistochemistry studies of the skin of 16 healthy volunteers and 16 patients suffering from vulgar vitiligo with the determination of the contents of immature (CD1a+) and mature (CD83+) subpopulations of dendritic cells (DCs) as well as CD4+ and CD8+ lymphocytes in the epidermis and perivascular infiltrates of the derma. They revealed an increased quantity of CD1a+ and CD83+ DCs in areas of depigmented, peripheral and perifocal normally pigmented skin of vitiligo foci. DCs with the CD1a+ phenotype were revealed both in the epidermis and in the derma while DCs with the CD83+ phenotype were revealed in the derma only. A higher quantity of CD4+ and CD8+ lymphocytes than in healthy volunteers was also revealed along with the increased contents of DCs in all three areas of vitiligo foci. The authors established a strong correlation between the quantity of CD83+ DCs and CD4+ lymphocytes in the depigmentation zone (r=0.84; Р
Neurosyphilis: from diagnostics to treatment part ii: diagnostics, therapy and prognosis
Authors: RODIKOV M V , PROKHORENKOV V I
Published: February 2022

The article discusses the current concepts of lesions of the nervous system at syphilis. It also presents data about diagnostics,
therapy and prognosis of neurosyphilis.
Analysis of the epidemiological situation and dynamics of std and dermatosismorbidity in the territory of the russian federation
Authors: KUBANOVA А A , LESNAYA I N , KUBANOV A A , MELEKHINA L YE , KASPIROVICH M A
Published: February 2022

The article presents an analysis of the morbidity rate for STDs and dermatoses based on the data from official governmental statistical
reports by subjects, federal districts and Russian Federation on the whole in 2009. The analysis covered the dynamics of the
morbidity rate for STDs and dermatoses for the period of 2003-2009.
The genetic factors in aetiology and pathogenesis of psoriasis
Authors: Kungurov N V , Filimonkova N N , Golubtsov V I , Korkhmazova S A
Published: February 2022

The results of genealogical and molecular-genetic assays of 250 patients with psoriasis are represented. The markers of increased and decreased risk of developing psoriasis have been detected; a multifactorial nature of the disease has been documented.
Results of investigation of the common immunoglobulin isotypes in Lues patients
Authors: Ponomareva M V , Levchik N K , Surganova V I , Girsh V A , Medvedeva YU A
Published: February 2022

The investigation of the level of common immunoglobulins in 59 patients with Lues and 23 patients with seroresistent Lues revealed some peculiarities that depend on both the clinical form and duration of the infection process as well as the presence of an associated specific affection of the central nervous system. Clinical sings typical for secondary Lues of the skin and mucus membranes are accompanied by intensified synthesis of the proinflammatory isotypes lgМ and IgG3 in the blood. Early hidden Lues is associated with formation of the antiinflammatory IgA isotype. An increased antibody formation is typical for early types of Lues whereas immunoglobulin levels in late types of the disease are normal. In case of a luetic affection of the central nervous system a decreased production of IgM is revealed.
Peculiarities of up-to-day running and epidemiology of the epidermolysis bullosa in the Krasnodar Territory
Authors: KUBANOVA A A , MURASHKIN N N
Published: February 2022

Analysis of the incidence and clinical peculiarities of the bullous epidermolysis in children at Krasnodar Territory circumstances is represented. The authors conclude that there is a growth of the incidence of the various forms of bullous epidermolysis in pediatric patients. They describe the results of analysis concerning the present clinical polymorphism of the disease.
Selection of drugs for treatment of gonococcal infection based on the results ofthe monitoring of N. gonorrhoeae antibiotic resistance
Authors: Lesnaya I N , Solomka V S , Frigo N V , Kubanov A A , Polevshchikova S A , Sidorenko S V
Published: February 2022

The article presents recommendations for selecting drugs for treatment of gonococcal infection based on the results of the monitoring of N. gonorrhoeae antibiotic resistance in 2009 and 2005-2009. It was shown that it is not recommended to use penicillin, tetracycline and ciprofloxacin in the territory of the Russian Federation because of the high level of N. gonorrhoeae resistance to these drugs. The drug of choice for gonorrhea treatment in the Russian Federation is Ceftriaxon because of the high level of N. gonorrhoeae sensitivity (100%). It is recommended to use spectinomycin for gonorrhea treatment only in the Ural and Far Eastern Districts; azithromycin - only in the Ural and Central Districts characterized by the high level of N. gonorrhoeae sensitivity to these antimicrobial drugs, and it is necessary to use spectinomycin and azithromycin in other federal districts of Russia only under control of determination of N. gonorrhoeae sensitivity.
Analysis of the incidence of revealing oncogenic types of the human papillomatosis virus in females with gynecological pathology
Authors: Blatova O L , Kontorshchikova K N , Andosova L D , Mikhaleva O V , Kudel'kina S YU
Published: February 2022

Study purpose: to assess the overall contamination with the human papillomatosis viruses and the viral load in virus-positive women using the polymerase chain reaction. Totally 4105 women referred to medical clinics of Nizhny Novgorod for the treatment of various gynecological diseases were examined. At assessment of overall viral contamination it was demonstrated that 962 women among 4105 (23.4%) were virus-positive. By incidence, the following viruses in virus-positive subjects were the leading: high cancerogenious risk types of viruses 16/18 in 33% of women, 31/33 types in 9.5%; 6/11 types in 12%. The amount of patients with diagnosed clinically significant concentrations of viruses was slightly higher than the amount of women with clinically insignificant concentrations of viruses as 119 and 99, respectively (54% against 45%).
Role of recognizing receptors in the initiation of immune inflammation in theskin of psoriasis patients
Authors: Katunina O R , Rezaikina A V , Kolykhalova O I
Published: February 2022

The article presents data on the pathogenetic role of Toll-like receptors in the development of immunopathological reactions in the
skin. The authors examined the distribution and content of Toll-like receptors TLR2, TLR4 and TLR9 in the affected skin of psoriasis
patients. They revealed a statistically significant increase in expression of Toll-like receptors TLR2 and TLR4, which can play an
important role for the formation of the inflammatory process involving cells of the adaptive immune system.
The use of topic antibiotics for treatment of acne
Authors: Samtsov A V
Published: February 2022

The article contains the literature data concerning the efficacy and safety of topic antibiotics for treatment of acne. The results of studies investigating the efficacy of clindamycin external formulations in patients with acne are shown.
Specific lesion of the knee joint in a patient with syphilis
Authors: Kubanov A A , Katunin G L , Kitayeva N V , Katunina O R , Rotanov S V , Nesterova T V
Published: February 2022

The article presents a case of a rare form of late syphilitic arthritis. It also describes the potential of using the polymerase chain
reaction method in the diagnostics of late forms of the syphilitic infection.
MELACAK ILLAT HUKUM LARANGAN WARIS BEDA AGAMA
Authors: Wahyudi Muhamad Isna
Published: February 2022

AbstrakKompilasi Hukum Islam (KHI) tidak mengatur waris beda agama secara jelas, KHI hanya mensyaratkan pewaris dan ahli waris memiliki agama yang sama. Di pengadilan, hakim-hakim Pengadilan Agama menggunakan wasiat wajibah untuk membagi harta warisan dengan ahli waris non-Muslim, berdasarkan yurisprudensi Mahkamah Agung Nomor 368 K/AG/1995. Sebagai hasilnya, perbedaan agama masih menjadi halangan bagi Muslim dan non-Muslim untuk saling mewarisi karena penerapan hukum tanpa mempertimbangkan illat hukum larangan waris beda agama. Dalam hal ini, penting untuk meneliti illat hukum hadis yang melarang waris beda agama sebagaimana yang dicoba dilakukan oleh artikel ini. Untuk melakukan penelitian tersebut, penulis menggunakan pendekatan usul fikih dan hermeneutika. Hasilnya, penulis sampai pada kesimpulan bahwa illat hukum hadis yang melarang waris beda agama adalah karena unsur permusuhan dan kejahatan, dan bukan karena perbedaan agama. AbstractKompilasi Hukum Islam does not regulate interfaith inheritance distinctly, it only requires the testator and the heirs have the same religion. At court, judges of religious courts employ obligatory bequest (wasiat wajibah) to share inheritance with non-Muslim heirs, based on jurisprudence of the Supreme Court Number 368 K/AG/1995. As the result, different faith still become hindrance for Muslim and non-Muslim to inherit each other due to law enforcement without considering the legal reason (ratio legis) of the law. In this case, it is important to investigate the legal reason (ratio legis) of the hadith that prohibits the interfaith inheritance as this article tries to do. To do the investigation, the author employs Islamic legal theories (usul fikih) and hermeneutics approach. As the result, the author comes to the conclusion that the ratio legis of the hadith that prohibits the interfaith inheritance is due to hostility and crime elements, and not due to different faith.
KONTRADIKSI PENGATURAN HUKUMAN PELAKU PELECEHAN SEKSUAL TERHADAP ANAK DI ACEH
Authors: Rachmad Andi , Amdani Yusi , Ulya Zaki
Published: February 2022

Kajian ini bertujuan untuk menelusuri kontradiksi pengaturan hukuman dalam tindak pidana pelecehan seksual terhadap anak di Aceh pasca diberlakukannya Qanun No. 6 Tahun 2014. Pengaturan hukuman pelecehan seksual terhadap anak dalam hukum jinayat di Aceh mempunyai perbedaan penafsiran dengan peraturan perundang-undangan lainnya termasuk UU No. 35 Tahun 2014 tentang Perlindungan Anak. Sehingga esensi efek jera bagi pelaku yang seharusnya menjadi bagian tujuan pemidanaan tidak begitu tercapai. Selain itu, Qanun Jinayat juga berpotensi untuk terjadinya impunitas bagi pemerintah dengan adanya Pasal 9 dan Pasal 11 Qanun No. 6 Tahun 2014 mengenai alasan pembenaran serta alasan pemaaf. Metode yang digunakan dalam tulisan ini yaitu metode yuridis normatif, dengan menggunakan data sekunder atau data kepustakaan.
DEVELOPMENT OF TRAINING FOR THE POSITION OF REGISTRARS IN THE SUPREME COURT
Authors: Ridwan Moch
Published: February 2022

The registrar's position within the Supreme Court is a career position with the status of a Civil Servant, who is specifically tasked with regional and central courts to receive, examine, adjudicate and settle registered cases. The clerk of the court who serves in the Court has an important role in handling the administration of the trial and the execution of the judge's decision in the Court. This role further clarifies the position and orientation of the function of the part of justice services for citizens optimally. This study aims to develop an education and training policy plan that supports the profession of court officials before carrying out their duties and functions as Registrars.This study uses a qualitative method with a normative juridical approach in the field of education and training. The results of this study found that the current administration of education and training for registrars, such as curriculum content and learning time is still lacking as a basis for competencies and specifications for job career paths required by the organization. This needs to be adjusted to the needs of the organization in meeting the professional standards of the clerkship position within the Supreme Court.
INDEPENDENCE OF BUDGET MANAGEMENT TO REALIZE THE INDEPENDENCE OF JUDICIAL INSTITUTIONS
Authors: Rumadhan Ismail
Published: February 2022

The Supreme Court in carrying out the function of judicial power is carried out independently so that it is not possible for intervention from other parties that can affect its function. However, the independence of the Supreme Court has not been fully strung together in accordance with the concept of independence in the exercise of judicial power. This can be seen in the Supreme Court's budget, the amount of which is still determined by the government. This condition will certainly affect its independence, because the budget is a support for the Supreme Court in carrying out the functions of judicial power. In this discussion, the method used is normative juridical. The benefit of this research is that it can become a reference for the Supreme Court to form an independent budget pattern so that it can carry out its functions independently. The conclusion of this study is that the Supreme Court has not been able to carry out its functions independently as outlined in Article 24 paragraph (1) of the 1945 Constitution, so it is necessary to change regulations by aligning the rules so that the Supreme Court can prepare its budget independently.
DESIGNING INSTRUCTIONAL MATERIALS FOR TEACHING AND LEARNING WRITING RECOUNT TEXT THROUGH EDMODO PLATFORM
Authors: Abisay Merry Elisabeth Elsina , Rahayu Apriliaswati
Published: February 2022

This research aims to design instructional materials for teaching and learning writing recount text through the Edmodo platform to tenth-grade students of SMA Kristen Abdi Wacana Pontianak. This instructional material was designed based on the teacher's interview, analysis of the current syllabus, and the English textbook. The researcher applied ADDIE as the research model. In this research, the researcher only implemented three phases which are analyzing, designing, and developing (ADD) without implementing and evaluating phase because of time limitation. The materials and tasks were indicated the teaching and learning focus only on writing recount text. This instructional was designed to include learning through digital learning media. Thus, some of the materials and tasks were provided on the Edmodo platform. The main structures of the instructional are the books' cover, preface, syllabus, basic competence and indicator competence, learning goals, material, and task. The researcher used expert validation to make sure that the material was usable. It revealed that the interpretation result of the product was very good. Besides, these instructional materials which were designed indicate that it is workable as the teaching materials in SMA Kristen Abdi Wacana Pontianak.
THE PARENTAL INVOLVEMENT IN FACILITATING LANGUAGE EXPOSURE FOR A LEARNER’S SPEAKING ABILITY (A CASE STUDY ON A 9-YEAR-OLD CHILD)
Authors: Alrosanty Karunia Sholihah , Susilawati Endang , Wardah Wardah
Published: February 2022

This research aimed to discover the parental involvement from the mother in facilitating the language exposure to improve the learner’s speaking ability. This research was a case study and applied the procedure from Yin to design steps of this research: planning, designing, collecting, analyzing, and sharing. The researcher interviewed the learner’s mother using the interview guidelines and observed the daily activity. Therefore, the researcher discovered that using English in daily conversation, supporting the learner when using English during the daily conversation and teaching-learning process, using English during the teaching-learning process, providing media to support the learner, stimulating English to the learner, and assisting or monitoring the learner when using the media provided a good amount of language exposure for the learner to improve his speaking skill, especially his fluency and its function in transaction and interaction. These parental involvements worked in one unity like a chain reaction to build a language exposure that would expose the learner and improve the learner’s speaking.
TEACHING VOCABULARY IN TRANSACTIONAL TEXT USING ROTE LEARNING
Authors: Taratika Hedya
Published: February 2022

The aim of this research is to improve students’ vocabulary in the transactional text by using Rote Learning for the seventh grade students of MTs Negeri 02 Pontianak in the academic year 2019/2020. The method used in this research is classroom action research which was conducted in two cycles. The subject of the research is 36 students of VII E class, consisting of 17 females and 19 males. In collecting the data, the researcher used observation checklist, field note, and achievement test. It was found that students’ vocabulary improved from cycle 1 to cycle 2. In the first cycle, 14.2% equal to 6 students passed the standard minimum score and it increased up to 91% or 32 students in the second cycle. By using Rote Learning in teaching vocabulary, the students could easily memorize new vocabulary. The students were actively engaged during the learning process. In short, Rote Learning is an appropriate method for the improvement of students’ vocabulary mastery.
INVESTIGATING THE RELATIONSHIP BETWEEN CULTURAL INTELLIGENCE AND STUDENT’S LISTENING COMPREHENSION
Authors: Dewi Desi Surlitasari , Wilany Eka , Sidabutar Isak Steven , Ria Tiara Nove
Published: February 2022

Student’s listening comprehension could be affected by several factors, one of the factors is student’s cultural intelligence. It is an ability to grasp and reason correctly any problem as education, government, business, and academic research. This study aimed to find out the correlation between students’ cultural intelligence and their listening comprehension at first semester students of English Department Universitas Riau Kepulauan in the academic year of 2020/2021. The data of the research were students’ cultural intelligence scores derived from cultural intelligence scale and student’s listening comprehension from IELTS listening tests. The population of the research were 28 students of first semester of English Department of Universitas Riau Kepulauan. Before testing the hypothesis, a normality test was conducted by using saphiro wilk to ensure that the data were in normal distribution. The data of cultural intelligence had a significance value of 0.397 and 0.372 for listening comprehension which is bigger than 0.05 with the degree of freedom 28. Therefore, it can be concluded that the data of listening comprehension and cultural intelligence were normal. After conducting the hypothesis, it was found out that rcalculated(0.217) is lower than rtable(0.374). The finding of the study concluded that there was no significant correlation between students’ cultural intelligence and students’ listening comprehension. However, the positive correlation implied that possessing higher cultural intelligence might be beneficial for student’s listening comprehension.
FIGURATIVE LANGUAGE IN THE STATLER BROTHERS’ SELECTED SONG LYRICS FOR LITERATURE TEACHING
Authors: Ghanaro Mohammad , Hidayat Nur , Sodiq Jafar
Published: February 2022

Figurative language and its meaning is always been a part of literary work. This study aims to identify the types of figurative language used in The Statler Brothers’ selected song lyrics, to find the meaning of the figurative language used in the selected song lyrics, and to elaborate the contribution of the study for literature teaching. The research design of this study is qualitative research. In data collection of the study, the writer has analyzed The Statler Brothers’ selected songs namely “Bed of Rose’s”, “New York City”, “Flowers on the Wall”. “Elizabeth”. “Do You Know You Are My Sunshine”, “Pictures”, and “We Got Paid by Cash”. The study results the dominant types of figurative language used in the songs is hyperbole as classified by using Kennedy’s theory. The songwriter uses hyperbole to deliver the idea and feeling effectively which is suitable to Kempson’s theory. The figurative language in The Statler Brothers’ songs can be used as alternative learning material to literature teaching. The writer suggests that the students should learn more about the meaning and the nature of words and sentences. This study is expected to be alternative reference to the next researcher to explain more about figurative language.
Many-Body Mechanochemistry: Intra-molecular Strain in Condensed Matter Chemistry
Authors: Hamilton Brenden , Strachan Alejandro
Published: February 2022

Mechanical forces acting on atoms or molecular groups can alter chemical kinetics and decomposition paths. So called mechanochemistry has been proposed to influence a variety of processes, from the formation of prebiotic compounds during planetary collisions to the shock-induced initiation of explosives. It has also been harnessed in various engineering applications such as mechanophores and ball milling in industrial applications. Experimental and computational tools designed to characterize the effect of mechanics on chemistry have focused exclusively on simple linear forces between pairs of atoms or molecular groups. However, the mechanical loading in condensed matter systems is significantly more complex and involves many-body deformations. Therefore, we propose a methodology to characterize the effect of many-body intra-molecular strains on decomposition kinetics and reaction pathways. We combine four-body external potentials with reactive molecular dynamics and show that many body strains that mimic those observed in condensed matter encourage bond rupture in a spiropyran mechanophore and accelerate thermal decomposition of condensed TATB, an energetic material. The approach is generalizable to a variety of systems and can be used in conjunction with ab initio molecular dynamics, and the two examples utilized here illustrates both the versatility of the method and the importance of many-body mechanochemistry.
Microbiota y su relación en el cáncer
Authors: Bigoni Ordóñez Gabriele Davide , Otavalo Anguisaca Christian Fernando , Machuca Carpio Carlos Andrés
Published: February 2022

La microbiota humana está conformada por una amplia diversidad de microorganismos que habitan nuestro cuerpo, desempeñando roles muy importantes en el mantenimiento de la homeostasis. Sin embargo, cada vez existe más evidencia que relaciona estados conformacionales de la microbiota con la etiología y fisiopatología de distintas enfermedades en el ser humano entre ellas el cáncer. En esta revisión se detallan algunas interacciones moleculares a través de las cuales la microbiota incide en la fisiopatología del cáncer, el papel del virioma y su posible aplicación como un potente tratamiento. Finalmente, entender la relación entre la microbiota y el cáncer, permitirá tanto una mejor comprensión de la carcinogénesis como el desarrollo de nuevas estrategias médicas y enfoques dirigidos a la prevención, tratamiento y diagnóstico de esta enfermedad de manera mucho más precisa.
Presentación Editorial
Authors: Meneses Ruiz Dulce María
Published: February 2022

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RELIGIOUSITY IN THE STORY “A DEER THAT ALWAYS REMEMBERS GOD”: FABLE FROM SUNDA LAND
Authors: Atisah Atisah
Published: February 2022

This paper aims to analyze and reveal the values of religiosity in the animal story or fable "A Mouse Deer Who Always Remembers God". The method used is descriptive analysis method and the theory used to analyze the work is an objective theory based on the work itself. In the fable, the deer figure is very famous, he is smart and always gets a solution when facing problems. He often uses his senses well. In the story "A Mouse Deer Who Always Remembers God", the deer figure always gets a solution to every problem because he always remembers God. The author of the (anonymous) deer story seems to realize that even a creature (animal) always remembers God, what about us humans? By always remembering God life will be saved. This is the hidden message of the author. This fable genre turns out not only to function as entertainment, it also has various functions such as didactic functions, advice, satire, and even.AbstrakTulisan ini bertujuan untuk menganalisis dan mengungkapkan nilai-nilai religiusitas dalam cerita binatang atau fabel “Seekor Kancil yang Selalu Ingat Kepada Tuhan”. Metode yang digunakan adalah metode deskriptif analisis dan teori yang digunakan untuk menganalisis karya adalah teori objektif yang bertumpu pada karya itu sendiri.  Dalam fabel sosok kancil sangat terkenal, ia berwatak cerdik dan selalu mendapat solusi ketika menghadapi masalah. Ia sering menggunakan akal dengan baik. Pada cerita “Seekor Kancil yang Selalu Ingat Pada Tuhan”, sosok kancil selalu mendapat solusi  dari setiap masalah karena ia selalu ingat pada Tuhan. Pengarang cerita kancil (anonim) tersebut tampak menyadari, bahwa seekor makhluk (binatang) pun selalu ingat Tuhan, bagaiman dengan kita seorang manusia? Dengan selalu mengingat Tuhan hidup akan selamat. Inilah pesan tersembunyi pengarang.Genre fabel ini ternyata tidak hanya berfungsi sebagai hiburan, juga memiliki berbagai  fungsi seperti fungsi didaktik, nasihat, sindiran, bahkan kritik sosial.
A Web GIS Application for the San Bernardino County Department of Public Health
Authors:   , Chacon Henry
Published: February 2022

The existence of well-water contaminants can impact negatively on human health when ingested for drinking water due to the deficient information about these pollutants in San Bernardino County. The San Bernardino County Department of Public Health is dedicated to protecting its residents’ health by providing a look-up table system, which contains general information about harmful pollutants. This project report explores the use of geographic information systems (GIS) to significantly enhance the water well look up table system for conveying timely and accurate information to end users. This GIS framework features a cloud-based system that encompasses interactive web maps and metrics dashboard, which are important for location-based data visualization. The research delivers new insights into how GIS technology can effectively convey comprehensive well-water pollutant information, and enhance the data management system, so users can make informed decisions for well-water consumption.