bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute oral toxicity of herbo-mineral combination: Talisadi yoga in Wistar albino rats
Authors: Jaiswal Nikita , Karkare Manjusha , C S Divya
Published: January 2025

Talisadi yoga (TY) has been used as an herbal contraceptive. Before any product is released into the market, the toxicity study parameters are necessary to generate data that is safe for scientific use. An in vivo study was carried out on female Wistar albino rats at the Institute for Industrial Research and Toxicology (IIRT), Ghaziabad. The study aimed to evaluate the acute oral toxicity (AOT) study of TY by following the guidelines of OECD 425: AOT-Up and Down Procedure. Healthy female Wistar albino rats, of body weight 200±20 g, were selected for study and used stepwise according to the guidelines. The study was conducted with a single starting dose of 2000 mg/kg body weight. The test sample was administered orally at dose volume of 10 ml/kg to one female rat. The treated animal was closely observed for clinical signs of intoxication during the first four hours of TY administration. Thereafter, the animal was observed periodically at a 12-hour interval for 48 hours. No sign of toxicity or mortality was observed in the 48 h; hence, another two animals were dosed at the same dose level and observed for 48 h and finally for 14 days after the administration of the TY, respectively. Since three animals survived at the tested dose level (2000 mg/kg b. wt.), the TY tested for AOT, was found non-hazardous to Wistar albino rats. According to the Globally Harmonised System of Classification and Labelling of Chemicals (GHS), it comes under Category 4 (LD50 > 2000 mg/kg).
Impact of eight weeks of Spirulina supplementation on body fat reduction in overweight young males: A randomized controlled trial
Authors: Bera Rajib , Ghosh Badshah , Biswas Subhashis
Published: January 2025

Spirulina, a blue-green microalga, is high in protein, vitamins, minerals and antioxidants, making it a popular supplement for improving general health. Due to its potentiality for fat metabolism, the study aims to explore the effect of eight weeks of Spirulina supplementation in reducing body fat in overweight young males. Following CONSORT 2010 checklist, eight-week placebo-controlled trial has been implemented involving twenty participants. The experimental group received 5 grams of Spirulina supplementation for eight weeks. The intake frequency increased from 3 days per week in the first week to daily by the sixth week, ensuring controlled adaptation.  No significant differences were found in demographic and anthropometric characteristics between the controlled and experimental groups. Spirulina supplementation led to a slight reduction in body fat percentage in experimental group, though the changes were not statistically significant (p=0.75). The reduction of body fat in the supraspinal and subscapular regions was relatively higher in the experimental group volunteers. The findings of the study indicate that providing overweight young boys with Spirulina supplementation for eight weeks did not have a significant impact on reducing body fat or modifying other physical measurements. The absence of significant change in body composition can be attributed to the duration of intervention, dosage and individual variability in response. The synergy of Spirulina supplementation and physical activity could be pivotal in effective weight control. Further research is required to examine the possible benefits of using Spirulina supplementation with other lifestyle strategies to achieve an effective reduction of body fat.
The Effect of Medhya Rasayan Ghrita on Senile Dementia – A case report
Authors: Kombe Pooja Sanjay , Kuchewar Vaishali , Khan Almas Yaser , Lagad Abhilasha Chatrgun
Published: January 2025

Introduction: Neurological diseases are the most life-threatening of all diseases. Among these, senile dementia is a deteriorating condition that affects patient’s memory, thinking ability, and intellectual. Here is a case of mild cognitive impairment was successfully treated with Ayurveda rejuvenation therapy. Here, the patient, who was 67 years old, came to Kayachikitsa OPD with one of his relatives. He used to have difficulty doing daily activities like driving and keeping finances on his own, as well as some memory issues like remembering some past events. The Mini Mental Scale Examination (MMSE) score of this patient was 20, which means mild cognitive impairment. The patient has taken many medicines, but the condition remained the same. This patient was treated with Medhya Rasayana Ghrita for three months. Then, after the completion of duration of 90 days, the Mini Mental Scale Examination (MMSE) score was improved up to 26, which means no cognitive impairment. There was a significant improvement in his orientation, attention, recall and copying skills. Rasayana medicine is, made with Madukaparni, Guduchi, Shankhapushpi, Yasthimadhu and Go Ghrita. Also, quality of life improvement was also present in patient.
A clinical evaluation of Siddha herbal formulation Panchathaarai kuzhambu (Internal medicine) and Ottrai thalaivali thylam (External medicine) in the management of Ottrai thalaivali (Migraine)
Authors: T Sophiya , G Sankareswari , T Lakshmi Kantham
Published: January 2025

Migraine is a syndrome of headache which is benign and re-occurring, along with various neurological dysfunctions, nausea/vomiting etc, affecting about 20% of females and 6% of males at some point in life. It affects over one billion people worldwide. According to Siddha, Ottrai thalaivali (migraine) is characterized as unilateral headache, lacrimation, irritability, sighing, fatigue, tremor, startling, loss of appetite and tingling sensation. Research studies regarding Migraine was searched in databases like PubMed, Google scholar, scopus, web of science, using keywords Migraine and siddha, Migraine AND Panchathaarai kuzhambu, Ottrai thalaivali and Clinical trial. Eventhough, there are a few papers proving the effectiveness of ayurvedic treatment regimens for migraine, No works have been found relating siddha clinical trials and migraine. Also as the disease requires long term management, there is a need to look for herbal formulations that can be effective in the management of Migraine. The herbal formulations Panchathaarai kuzhambu and Ottrai thalaivali thylam have been taken for the study to prove its effectiveness on Migraine. A Clinical trial was conducted on 10 patients diagnosed with Ottrai thalaivali(Migraine). The trial drugs Panchathaarai kuzhambu was given in a dose of 2gms twice daily along with cow’s milk and Ottrai thalaivali, 70ml as bath oil twice in a week, given for 48 days. The results using HIT-6 Score and Headache diary showed that there was significant relief in the patients and there was no untoward side-effects in any patients.
In-vitro Anti-adipocytic activity of Katuka (Picrorhiza kurroa Royle ex Benth)
Authors: Santosh Pandey Prachi
Published: January 2025

When we look back at human evolution, we observe that humans are closely bonded with nature. We highly depend on resources derived from nature for our day-to-day lives. Whether in good health or disease, we greatly rely on plant, animal, and mineral extracts. With the advent of time, as humans evolved, we started using artificially prepared chemical formulations and modern drugs - for prevention and fighting against diseases. In Ayurveda, plants, animals, and minerals are used to treat diseases. Katuki (Picrorhiza kurroa Royle ex Benth) is an ayurvedic herb that belongs to the Plantaginaceae family and is primarily found in the Himalayan region. Katuki has multi-factorial use in the treatment of various ailments. It is widely used as hepatoprotective, preventing and curing liver damage caused by hepatotoxic agents. Though Acharya Charak has mentioned Katuki in Lekhniya Mahakashaya, it is scarcely used for treating Sthoulya (Obesity). Hence, through a research study, here is an attempt, to prove the activity of Katuki in the inhibition of fat cell formation using the 3T3-L1 cell line. Material and Methods: Katuki Rhizomes was purchased from, Dehradun, Uttarakhand. A modern drug, Orlistat was used as a standard drug. The 3T3-L1 cell line was procured from NCCS, Pune. Cytotoxicity of Katuki was studied using XTT Assay. Oil Red O staining was used to study the anti-adipocytic activity of Katuki. Result: Katuki was found to be safe for 3T3-L1 cells. Katuki was tested in four different concentrations. After the test results, it was found that the fat cell formation on the differentiated 3T3-L1 cell line treated with Katuki was significantly inhibited. Discussion and Conclusion: The test drug Katuki has shown noteworthy anti-adipocytic activity on the 3T3-L1 cell line in all the studied concentrations. However, the anti-adipocytic effect of Katuki was not dose-dependent.
An observational study of Consideration of Anguli Pramana in view of the Health Status in the present era
Authors: Visave Pratibha , Choudhari Deepali
Published: January 2025

Introduction: Anguli pramana is an age-old technique of human body measurements stated in Ayurveda. Acharyas have mentioned Anguli pramana for various parts of the body. The study aimed at its validation in the present era on the basis of health status. There are so many factors related to the health status of individual. Hence, the present study aimed at health status wise consideration of Anguli pramana. Method: With prior ethical permission, 770 healthy participants of both gender between age group 18-50 years in Ahmednagar and Nashik region were selected. Measurements were taken for selected body parts. The middle finger width of the right hand at proximal interphalangeal joint was used as a unit for Anguli pramana. Collected data analyzed using the student’s t test for inference. Result: On comparison of measured values for selected parameters and the standard values stated by acharya in both genders found statistically different except for few parameters i.e., Pad parinah, Pad vistar and Prakoshṭha ayam. Discussion: The study shows variations in values obtained by Anguli pramana. This could be due to evolutionary changes and lifestyle of a human being. Though the findings are applicable to the selected sample size and selected parameters, the study could further be extended as this is a non-invasive ancient method of anthropometry. Revision of all the values for the present era will definitely serve as an alternative method for prediction of health of human being.
Stability study of Ashtaguna manda As Ready-To-Eat (RTE) form – An Ayurveda Based Therapeutic Diet Formulation
Authors: Jena Raktimabha , Tonni Sanjeev , Bhosale Savita
Published: January 2025

This article discusses the standardisation of Ashtaguna manda as Ready-To-Eat (RTE) form, an Ayurveda-based therapeutic diet formulation used for conditions like Jwara, Ajeerna and Agnimandya. Ashtaguna manda, which is noted for its properties such as deepana (appetizer), paachana (digestive), basti-shodhana (cleansing of the urinary bladder), rakta-vardhana (blood enhancer), and ruchikara (taste enhancer), is known to restore normal digestive functions. Ashtaguna manda is subjected for usage in fresh form/ within 24 hours. So, the preparation of Ashtaguna manda was subjected to powder form as Ready-To-Eat (RTE) food. The preparation was standardised and analysed for its organoleptic, physical characteristics and physico-chemical properties. In terms of organoleptic characteristics, Ashtaguna manda in RTE form exhibited a whitish colour at initial month (0 day), which turned creamish white after three and six months of storage. The odour remained unchanged for up to six months. The pH value, indicating acidity and alkalinity was 6.45 at initial month (0 day), 5.26 at three month, and 5.39 at six month, showing slight acidity. The total solids ranged from 1.534% at initial month (0 day) to 1.746% at three month and 1.850% at six month. Specific gravity was 1.007 at initial month (0 day), 1.012 at three month, and 1.009 at six month. Non-reducing sugars were present, aiding in consistency and preservation, while reducing sugars were absent throughout the six month storage period. Carbohydrates, proteins, and fats were present throughout the six month storage. The sample showed no presence of E. coli, S. aureus, P. aeruginosa, and S. abony during the six month storage. The total bacterial count was 03 cfu/gm, 05 cfu/gm, and 07 cfu/gm and the total fungal count was 01 cfu/gm, 03 cfu/gm, and 05 cfu/gm at initial (0 day), three and six months respectively. The established parameters were found to be adequate for standardising Ashtaguna manda as RTE therapeutic food made available in sachet form.
Comparative Study of Yogic Practices and Vyayama on Certain Physical and Mental Variables in Healthy Individuals
Authors: Yadav Jyoti , Tiwari Mamta , Vyas Rajiv , Singh Vineeta , Chowdhury Kanchan
Published: January 2025

Introduction: Now a days, erratic lifestyle, characterized by poor dietary habits, sedentary behaviours, busy schedule and stress have led to rising concerns about physical and mental well-being because these lead to arise of different illnesses condition. There is growing worldwide interest in traditional health practices like Yoga and Vyayama (exercise), as they are seen as complementary to conventional medicine. Studying both practices together offers a thorough grasp of how they support mental and physical well-being, resulting in more holistic wellness approaches. Objective: The aim of this research is to evaluate the effect of yogic practices and vyayama on certain physical and mental variables in healthy individuals. Material and methods: About 150 healthy volunteers fulfilling the inclusion and exclusion criteria have been registered randomly in three different groups for total period of 3 months. Three distinct follow-ups were conducted to evaluate changes in various objective parameters i.e., Flexibility, Agility, Body Mass Index (BMI), Muscular Strength and subjective criteria, Mental Health Inventory (MHI) – Multiple Sclerosis Quality of Life Inventory (MSQLI). Results: Results of this study showed that vyayama had greater effect on physical variables like and yoga had greater effect on mental variables. On intragroup comparison (Wilcoxon Singed Rank Test) there was statistically significant result seen in flexibility, BMI, and mental health in group A. On intragroup comparison there was statistically significant result seen in agility and muscular strength in group B. Conclusion: This study shows that the significance of Yoga and Vyayama as effective, non-pharmacological interventions for improving certain physical and mental variables. Their natural and holistic approach to enhancing well-being, without any side effects, makes them especially beneficial as preventive health measures.
A fortified cereal and Ayurveda herb-based diet (Guducyadi krushara) for Sickle cell disease (~Pandu) - A case report
Authors: Gohel Vashishth , Raskar Swapnil , Gehija Jaidev , Bhimani Komal
Published: January 2025

Introduction: Sickle Cell Disease (SCD) is considered as Beeja-Dustijanya and Pitta Dosha pradhan Vyadhi, which is counter with a drug-diet plan to alleviate the Crisis and symptoms of SCD, as the genetic origin of the disease makes it non-curable.  A diet made with herbs having antioxidant, rejuvenating properties is core for the treatment of disease, and "Guducyadi Krushra" is one among them. In the present study, a 12-year-old female child (diagnosed case of Sickle Cell Disease) was treated for 30 days with the Guducyadi Krushara as add-on dietetic management along with conventional therapy with hydroxyurea and folic acid. Methods: In this study, Guduci is taken as the primary Immunomodulator, processed to form Krushra made up of rice and green gram, and prescribed as a diet regimen for patients with Sickle Cell anemia. Results:  There is significant relief in the symptoms of crisis, pain, fatigue, and loss of appetite in the patient treated with Guducyadi Krushra as Pathya Aahara. which was not observed with conventional therapy alone. Discussion: The antioxidant, Anti-sickling, and rejuvenating properties of Guduci help to alleviate the symptoms of SCD and help to maintain the Quality of life of the patient. It promotes the healthy RBCs and prevents the sickling. Additionally, Krushara (Gruel) is easy to digest and has nutritive value and is accepted in different ethnic populations of India and hence easy to administer with good acceptance by children. It helps to maintain adherence and compliance to the therapy, which yields results. Conclusion: The use of Ayurveda herbs with diet as a regime will help to improve the clinical outcome and integration approach to reduce the burden of diseases like childhood SCD.
Chemical profiling of Mandak - A novel polyherbal combination
Authors: G Pratyusha , RS Hiremath
Published: January 2025

Introduction: In Ayurveda, drug formulation adheres to two principles: single-drug use and compound drug use, the latter known as polyherbalism. Mandak, a Novel Polyherbal combination of six drugs have shown better efficacy individually in the management of twak vikaras. Methods: This study aimed to evaluate raw and end product’s (Mandak) organoleptic, physicochemical, and phytochemical properties, along with chromatographic screenings via Thin Layer Chromatography (TLC) and High-Performance Thin Layer Chromatography (HPTLC), and Fourier Transform Infrared Spectroscopy (FTIR) to assess the synergistic effects of this novel combination. Results and Discussion: The microbial load of both the raw drugs and the compound mixture was within permissible limits. Physicochemical and phytochemical analyses confirmed the presence of compounds such as flavonoids, alkaloids, and tannins, recognised for their antioxidant, anti-inflammatory, anti-allergic, and antimicrobial properties. HPTLC profiling identified berberine (Rf ~0.36) and gallic acid (Rf ~0.59), with colour bands indicating various phytoconstituents such as red and yellow for alkaloids and blue for flavonoids and tannins etc. FTIR analysis detected hydroxyl groups linked to alcohols and phenols, which exhibit antioxidant properties, and carboxyl groups associated with lipids and proteins synthesis. The phytoconstituent composition may vary due to geographical distribution and time of collection. The compound drug’s components might work synergistically, enhancing antioxidant, anti-inflammatory, and wound healing activities. Conclusion: The diverse pharmacological activities of Mandak stem from its phytoconstituents, which could help create standard monographs for this novel combination. This study emphasises the importance of Mandak by evaluating its phytochemical properties and potential benefits in Ayurvedic practice.
Assessing the therapeutic potential of Banana blossom extract in ameliorating Mifepristone-Induced Polycystic Ovarian Syndrome in Rat Model
Authors: Patil Poonam Sambhaji , Kudatarkar Namit
Published: January 2025

Background: Polycystic ovarian syndrome (PCOS) is a syndrome defined by ovarian dysfunction which is marked primarily by elevated hormone levels and the presence of polycystic ovaries discovered on ultrasonography. Polycystic ovarian syndrome is an extremely prevalent lifestyle disorder that affects 6 out of 10 women. The management of polycystic ovarian syndrome is largely unclear. This study examines the possible use of Banana Blossom an herbal therapy in a rat model of polycystic ovarian syndrome caused by the medication mifepristone. Methods: For 13 days, female Wistar rats were given 20mg/kg b.w. of mifepristone daily to induce PCOS, which was verified by the sustained estrous cycle. The rats received treatment with Banana Blossom extract orally for 21 days at a dosage of 200, 400 and 800mg/kg b.w. after PCOS induction and standard treatment was metformin. Physical, biochemical parameter and oxidative stress marker was carried out using standard procedure. Result: The PCOS rats reported a significant decline (P˂0.001) in uterine weight, HDL, SOD as well as GSH levels along with a significant rise (P˂0.001) in body weight, periovarian fat, LDL, triglycerides, MDA and glucose level. Banana Blossom extract reversed these effects, with the 800mg/kg b.w. dose providing the most significant improvements in oxidative stress markers and biochemical parameters. Conclusion: After analysing the data, one can conclude that the banana blossom ethanolic extract exhibited an improved therapeutic effect on mifepristone induced polycystic ovarian syndrome in female Wistar rats.
Nephroprotective effect of the combination of Nisha and Amalaki in Alloxan-induced hyperglycaemic rats
Authors: Nair Dhanya Renuka , PY Ansary
Published: January 2025

Background: Experimental studies have shown that Nisha (Curcuma longa L) rhizomes and Amalaki (Phyllanthus emblica L) fruits possess antidiabetic, antioxidant and nephroprotective activity. Their combination is effective in Type-2 Diabetes. The present study was an attempt to assess the nephroprotective activity of the combination of powder of Nisha rhizomes and Amalaki fruits in alloxan induced hyperglycaemic albino rats. Methods: The in-vivo study was conducted at the facility in Govt. Ayurveda College, Thiruvananthapuram. Wistar rats of both sexes weighing 150-200 gm were induced with hyperglycaemia using intraperitoneal injection of Alloxan monohydrate (120mg/kg). The test drug in the ratio 1:4 (Nisha:Amalaki) was given in three groups in the doses, 0.108g, 0.216g and 0.432g /200g body wt. They were compared with normal control (euglycaemic healthy animals), diabetic control (no treatment hyperglycaemic rats) and standard conventional antidiabetic group administered with Glibenclamide in the dose 0.18 mg/200g body wt. After 30 days, blood, urine and tissue samples were collected and analysed for Morphological, Biochemical parameters and Histopathological changes. Results and conclusion: Statistical evaluation was done using Kruskal-Wallis Test and Mann-Whitney Test. Test drug given in dose 0.108g corresponding to human dose 6 g showed the best results with respect to Morphological and biochemical parameters among all treated groups. Histopathological parameters- glomerular and tubular changes and presence of infiltrative cells- returned to normal in all the treated groups which shows that euglycemia is important for prevention of renal changes in diabetics. The study shows that the drug combination is effective in preventing Diabetes induced renal damages.
A Review study on mechanisms of anti-inflammatory action of various Drugs and Ayurvedic formulations (Anti-inflammatory medications)
Authors: Gupta Supriya , Pathak Avnish , B Kothainayagi , Sharma Anupam
Published: January 2025

Inflammation is primarily a defensive and healing mechanism, to save the human body when challenged with trauma, infection, autoimmune, toxic and ischemic injuries. While chronic inflammation needs to be controlled almost in all pathological conditions like diabetes, cardio-vascular conditions, autoimmune diseases and carcinomas; most of the time even acute inflammation needs a control to certain extent like to control pain, swelling and fever for comfort and health. While a number of medications are available for same and newer formulations are still under work, various ayurvedic drugs are also well known to possess a significant anti-inflammatory effect with better adverse effect profile at times. Since there is a compulsion to move our efforts from curative to preventive aspects of healthcare, like the need of a diet with anti-inflammatory properties, it always is beneficial to understand how various plants and plant products possesses anti-inflammatory properties. An attempt is made to compile the mechanisms of action of various medicines and anti-inflammatory ayurvedic formulations, to give an overview of how all products come in the ambit of same group of biochemical interactions and pharmacological affects. This also emphasizes, why is it essential for every new formulation and conventionally used plant products to undergo studies to know exactly how it ensues its affects, herein anti-inflammatory actions. This also underlines how such knowledge helps to hypothesize newer mechanisms of action and novel drugs which may act by same or similar mechanisms of actions. This also provides the guidelines for approaches to develop newer medicines.
To ascertain the prevalence of diabetic retinopathy among the different dehaprakriti - A cross sectional study
Authors: Ade Jaykumar , Gat Srujali , Hadimani Satish , Pardeshi Raviraj , Usturge Revensiddha , Madgundi Anand , Chaudhari Bhojraj , Santosh Swami
Published: January 2025

Diabetic retinopathy (DR) is a common cause of vision problems worldwide. One in three diabetics has symptoms of diabetic retinopathy. Dehaprakriti is a unique concept of Ayurved. By knowing the concept of Dehaprakriti one can maintain homeostasis. Aim: Determination of the prevalence of diabetic retinopathy in the different Dehaprakriti. Materials and Methods: A simple randomisation study was conducted at SGR Ayurved College & Hospital Solapur, Maharashtra with appropriate consent. According to inclusion criteria, people with Diabetes Mellitus were screened. Fundoscopy was performed on all diabetic patients. Each patient with Diabetes Mellitus underwent funduscopy. The presence or absence of changes in diabetic retinopathy was noted in each patient. Identified subjects with diabetes retinopathy underwent detailed examination by Dehaprakriti. The study of Dehaprakriti was based on a proforma approved by the Maharashtra University of Health Sciences, Nashik. Result: For the study, 106 individuals with Diabetes Mellitus in total were enrolled. Of them, sixty patients exhibited signs of diabetic retinopathy. The overall prevalence of 56.6 percent was associated with diabetic retinopathy. 25% of people in Kaphavaat Dehaprakriti had diabetic retinopathy. Pittakapha is the Dehaprakriti that is least impacted. The group's prevalence was 10%. Conclusion: Changes in DR are observed to a greater extent in Kaphvaat Dehaprakriti individuals.
Metabolomics Profiling of Boerhavia diffusa (Punarnava): High-Resolution Mass Spectrometry Unveils Hepatoprotective Metabolites
Authors: Rajesh Saroj Adittya , K Ramachandra Reddy
Published: January 2025

Boerhavia diffusa (Punarnava), a highly valued medicinal plant in Ayurveda, has been traditionally used for its hepatoprotective properties. Despite its extensive use in treating liver disorders, the specific bioactive compounds and underlying mechanisms responsible for its hepatoprotective effects remain largely undefined. This study utilizes High-Resolution Mass Spectrometry (HRMS) to comprehensively analyse and profile the bioactive compounds in Boerhavia diffusa, aiming to uncover its hepatoprotective potential at the molecular level. The HRMS analysis revealed a diverse spectrum of phytochemicals many of which are associated with anti-inflammatory, antioxidant, and liver-regenerative activities. These compounds were further explored for their interactions with key hepatic pathways, particularly in mitigating oxidative stress, inhibiting inflammatory mediators, and regulating enzymes crucial for liver function and detoxification. The study further explores potential mechanisms of action of these phytochemicals through reviews of existing pharmacological data, proposing a multifaceted approach to liver protection that includes scavenging free radicals, reducing lipid peroxidation, and inhibiting pro-inflammatory cytokines. The findings underscore the potential of Boerhavia diffusa as a natural therapeutic agent for liver diseases, reinforcing its place in both traditional and modern medicine. These findings could facilitate the development of novel plant-based therapeutics aimed at liver health.
Anatomical study of shringataka marma using cadaveric dissection technique
Authors: Kumar Nishant , Ramola Pratibha , Fulara Sakshi , Lakshmi  , Singh Kameshwar Nath
Published: January 2025

In Ayurveda, the concept of Marma describes 107 vital points in the body where Prana, or life force, resides. These points are crucial because injury to them can result in sudden pain or even death. Among these, the Shringataka Marma is located on the nose and falls under the category of Urdhwajatrugat Marma or Sira Marma. It measures about 8 cm. ( which is equivalent to four angula) and in turn consists of four individual points. Injury to the Shringataka Marma is considered potentially fatal. In this study, the Shringataka Marma is analysed from the perspective of contemporary anatomy, comparing its location and associated components with insights from both Ayurvedic and modern medical literature. The aim is to explore the anatomical structures associated with the Shringataka Marma using the cadaveric dissection and also used to assess the relevance of ancient Ayurvedic concepts, such as those described by Sushruta, in the context of modern medical understanding.
Mechanism of Arkeshwara rasa to combat hepatocellular carcinoma
Authors: Jayakumar Remya , Dash Manoj Kumar , K Rama Chandra Reddy , Joshi Namrata
Published: January 2025

Background: Immunomodulatory treatments along with systemic and loco-regional methodology of treatment approach have reduced the incidence of Hepatocellular carcinoma (HCC) in recent observations. The phytomolecular applications have been seen to reverse the hepatic fibrosis aiding in regeneration of hepatocytes. The cytotoxicity of Arkeshwara rasa (AR) was investigated on HCC cell lines to observe the general signs of apoptosis. Methodology: The MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay and Ethidium Bromide/Acridine orange Assay (EtBr/AO) were subjected on AR to know the cytotoxicity and the apoptotic results. Results: The IC50 of 37.14 μg/ml was exhibited by AR against Huh 7 cell lines and the (EtBr/ AO) Assay demonstrated the early and late apoptotic features in comparison with Untreated and Doxorubicin standard drug. Conclusion: AR on the basis of present evaluation against HCC cell lines and previous results on various other cell lines might be able to check the pathogenesis progression of HCC cells initiating the apoptotic features or reviving the vulnerable cell from further damage because of the phyto-constituents or mineral inclusions. These preliminary observations have to be again revalidated with reverse transcription, cDNA synthesis, western blotting, cell cycle analysis, etc.
A Novel Topical Approach Using Carica papaya and Cellulose Sulfate for STIs Management: A Promising Prevention and Treatment for Sexually Transmitted Infections
Authors: Naidu Menda Akkulu
Published: January 2025

Objective: This study explores the efficacy of a novel topical formulation containing Carica papaya extract and cellulose sulfate as a potential prevention and treatment for sexually transmitted infections (STIs). The aim is to evaluate the antimicrobial properties of this combination and its safety for topical use in the prevention and treatment of common STIs. Materials and Methods:A topical formulation was prepared using Carica papaya extract and cellulose sulfate, chosen for their antimicrobial and protective barrier properties. The formulation was tested invitro against common STI pathogens, including Neisseria gonorrhoeae, Chlamydia trachomatis, and Herpes simplex virus (HSV). Cytotoxicity assays were performed using human epithelial cells to assess the safety of the formulation. In addition, animal models were used to test the efficacy of the formulation in preventing infection. Results and Discussion: The in vitro results demonstrated that the combination of Carica papaya and cellulose sulfate effectively inhibited the growth of bacterial and viral STI pathogens. The formulation showed a significant reduction in infection rates in the animal models, particularly for Chlamydia trachomatis and HSV. Cytotoxicity assays revealed no significant adverse effects on human epithelial cells, indicating the safety of the topical application. The synergistic effects of the antimicrobial properties of Carica papaya and the protective barrier formed by cellulose sulfate suggest that this formulation could serve as an effective, non-invasive treatment option for STIs. Conclusion: The study demonstrates the potential of a topical formulation containing Carica papaya and cellulose sulfate for STI management. It offers a promising alternative for the prevention and treatment of STIs, with minimal cytotoxic effects and broad-spectrum antimicrobial activity.
In Vivo Efficacy of Advanced Drug Delivery System Loaded with Different Medicaments For Regenerative Endodontics
Authors: Naidu Menda Akkulu
Published: January 2025

Aim: The aim of this study is to evaluate the efficacy of an advanced drug delivery system loaded with calcium hydroxide and calcium silicate for regenerative endodontic procedures. Materials & Methods: Preparation of Drug Delivery System: A biocompatible carrier material hydrogel is prepared which is capable of encapsulating calcium hydroxide and calcium silicate particles. Characterisation: The drug delivery system is characterised for its morphology and release kinetics. Animal Study: In vivo studies are conducted using animal models of pulpal injury or infection. The drug delivery system is applied in root canal procedures, and the regeneration of pulp tissue and formation of hard tissue barriers are assessed using histological and radiographic analyses. Results & Discussion: Sustained Release Property: The drug delivery system exhibits potent endodontics regeneration property with sustained release of calcium hydroxide contributing to effective bacterial elimination. Tissue Regeneration: The incorporation of calcium silicate promotes dentinogenesis and facilitates the formation of hard tissue barriers, leading to enhanced tissue regeneration within the root canal space. Conclusion: In conclusion, the advanced drug delivery system loaded with calcium hydroxide and calcium silicate shows great promise for enhancing regenerative endodontic procedures. Its ability to provide sustained release of medicaments, promote tissue regeneration, and improve treatment outcomes makes it a valuable tool in modern endodontic practice.
Pharmacognostical Evaluation of Jeevak/Crepidium acuminatum (D.Don) Szlach. Pseudo bulb
Authors: Ramita Maharjan , Vinamra Sharma , C Rudrappa Harish , Mahesh Kumar Mainali , Prerna Mysore
Published: January 2025

temperate zone that has high therapeutic value. It is known as Jeevak in Ayurveda and is one among the astavarga
The Importance of Guru - Shishya Parampara in Nath panth
Authors: Kumari Priya , K Rama Chandra Reddy
Published: January 2025

The worship of Lord Shiva and the application of sophisticated yogic techniques are the main focuses of the Nath Sampradaya (also known as the Nath tradition), a spiritual and religious movement within Hinduism. The custom, which dates back to the eighth century, is strongly linked to mythical saints like Matsyendranath and Gorakhnath. It places a strong emphasis on using Hatha Yoga, Kundalini Yoga, and other meditation techniques to achieve self-realization, spiritual awakening, and liberation (Moksha). The Guru-disciple relationship, in which the Guru imparts spiritual wisdom and esoteric knowledge, is what defines the Nath tradition. Additionally, the tradition encourages the development of mental and physical discipline, asceticism, and the use of mantras. The Nath Sampradaya has influenced the development of various schools of yoga, and its teachings continue to impact Hindu philosophy, meditation practices, and spiritual literature across India and beyond.
Yoga for PCOS: A Holistic Approach to Improving Symptoms, Quality of Life, and Mental Well-Being
Authors: Chaurasiya Shraddha , Bahadur Bajrang , Rai Sangeeta , Tiwari Mamta , Singh Royana , Sahni Chetan
Published: January 2025

as
Ghrita and different herbal inclusions on neurological disorders - A perspective review
Authors: Bhagat Kalpana , Manoj Kumar Dash  , Jayakumar Remya , Namrata Joshi
Published: January 2025

Introduction: Ayurveda ghrita dosage forms are well appreciated in the Classical treatises for different diseases and may be useful in neurological conditions such as these formulations are recommended since birth for memory enhancement and improving intellect as the major development of brain completes within the initial 5 years. So, these PUFA embedded preparations with DHA, AA, BA, etc are extensively screened out for the cognition, memory, neuro-protective, genesis of plasticity, etc in terms of herbal constituents added with the dosage form. Material and Methods: The Classical Ayurveda treatises and the databases like Pubmed, Scopus, Web of Science, etc were searched with the words like nootropic, PUFA, DHA, etc. The articles related with synaptic transmission and the phytochemical domination in the neurotransmission were separated for further understanding of mechanism. Results: AChE inhibitory action can preserve the acetyl choline activity while the synaptic transmission exhibited by α-Asarone of AC, BM, etc. Similarly, the Glutamate transmission with the NMDA receptor protected the neuronal degeneration from β-Amyloid like protein accumulation in CP constituents. The Serotonergic and Dopaminergic neurotransmission pathway were also regulated by the herbal and the lipid factors. These different pathways were somehow involved in the memory enhancement. Conclusion: The ghrita and the herbals mentioned were maintaining the neuronal synaptic transmission. Further clarification is necessary regarding the intrinsic pathway related to the mechanism of ghrita dosage form.
Cadaveric Study on Kurcha Sharir along with its modern perspectives
Authors: Devi Pal Ragini , Fulara Sakshi , Ramola Pratibha , Gautham Vijay Laxmi
Published: January 2025

In Ayurveda, Rachana Sharir examines the embryological and structural organization of the human body. One of the branches of Rachana Sharir that describes a certain body structure is Paribhasha Sharir. Literally, Paribhasha signifies terminology. The first step in understanding any given subject is to grasp its basic terminology and main concepts. Kurcha is among such unexplored topics that come from the sannipat of dhamani and snayu. Kurcha is examined in this study from the perspective of modern anatomy, contrasting its location and related elements with knowledge from both Ayurvedic and Modern medical literature. The purpose of the cadaveric dissection method is to investigate the anatomical structures related to the kurcha and to evaluate the applicability of traditional Ayurvedic concepts, such as those described by Sushruta, in the context of modern medical understanding.
Role of Ayurveda and Yoga in Treating Mental disorders - A Review
Authors: Verma Arun Kumar
Published: January 2025

A person's mental health is a personal and unique issue. We need to maintain good mental health because we are human. On the other hand, we form habits and behaviour’s that can contribute to poor mental health. These behaviour’s might be anything from minor annoyance to serious anxiety and sadness. The phrase "mental illness" is broad and encompasses nearly all mood-behaviour problems brought on by flawed perception, emotion, thought, and attitude. These people also struggle to fit in with other members of society. Mental illnesses impact individuals in every community worldwide and contribute significantly to the global burden of disease. Mental illnesses can begin early in life. If we take a look in Ayurveda so in Ayurveda also mental health has a great importance for all over healthy personality. Ayurveda consider prassana atma,indriya and mana beside the equilibrium of dosha, dhatu and mala as swastha.ayurvedadeals with four aspects of lifestyle which can ensure good health in us. These include right food (Ahara), right recreation (vihara), right routine (achara), and right thinking (Vichara) life. Observing certain practice ensure a healthy and happy life. There are lots of discussion regarding Aachar Rasayana, sadvrutta, pranayama, Aasans etc. in Ayurveda. All these are helpful to maintain proper mental health as well as to tackle mental illness. Role of these in altered mood behavior will be discussed in detailed in full paper.
A Comparative Study of Yogic Practices and Diet Therapy in the Management of Pre-Diabetes wsr to Glycemic Control: A Case Report
Authors: Kapil  , Pandey Ajai Kumar , Chowdhury Kanchan
Published: January 2025

Pre-Diabetes is growing with an alarming rate all over the world. It is a clinical entity between the normoglycemia and stage of Type II Diabetes mellitus. Faulty dietary habits and lifestyle errors play a key role in the pathophysilogy of Pre-diabetes. Pre-diabetics have higher risk for cardiovascular diseases, fatty liver, kidney failure and other associated complications of diabetes. The reason for the rising incidence of Pre-diabetes is due to the lack of public awareness, observation, follow-up programs and self-awareness about the conditions of disease. This report is about a case of successful reversal of Pre-diabetes to normal stage through Yogic practices and diet therapy. The selected patient was prescribed Yogic practices and diet therapy throughout the intervention. The trial patient reported glycosylated (HbA1c) as high as 5.9 % and after the intervention of Yogic practice and diet therapy, it was reduced to 5.2%. After three months intervention, fasting blood sugar dropped from 110 mg/dl to 90 mg/dl and postprandial blood sugar dropped from 165 mg/dl to 132 mg/dl and Weight reduced from 93 kgs to 90 kgs. He was responded well in terms of clinical symptoms of Pre-diabetes after the completion of trial intervention. Besides, no other lifestyle modification interventions were enforced during the whole trial period. The results concluded that consistent diet therapy and regular Yogic practice can not only maintain the blood sugar levels in patient of Pre-diabetic but also improve the patient general health and wellbeing.
QUANTUM COMPUTING
Authors: Godwin Premi Dr. M. S. , Susitra Dr. D. , Mana Dr. Suja Cherukullapurath , Velvizhi Ms. R , Nair Ms. Manju C
Published: January 2025

Quantum Computing represents a paradigm shift in computation, leveraging the principles of quantum mechanics to solve problems intractable for classical computers. This book provides a comprehensive exploration of quantum computing, encompassing its foundational concepts, architecture, algorithms, programming techniques, and real-world applications. Beginning with an overview and historical evolution, it delves into the fundamental differences between classical and quantum computing, highlighting key quantum mechanical phenomena such as superposition, entanglement, and interference. The book further examines quantum states, qubits, and gates, elucidating their roles in quantum computation. The architecture of quantum systems, including superconducting qubits, trapped ions, and photonic qubits, is analyzed alongside quantum circuits, hardware challenges, and error correction mechanisms. Core quantum algorithms, including Shor’s algorithm for factorization and Grover’s algorithm for search, are discussed with practical examples. The book also emphasizes quantum programming, featuring tools like Qiskit, Cirq, and PyQuil, and explores challenges in quantum simulation and circuit development. Applications in cryptography, artificial intelligence, drug discovery, and optimization are detailed, underscoring quantum computing’s transformative potential. The book concludes with an examination of challenges such as scalability, noise, and ethical concerns, while providing insights into future directions, including hardware advancements, emerging algorithms, and integration with classical systems. It serves as an essential resource for students, researchers, and professionals aiming to understand and contribute to the quantum revolution.

Keywords: Quantum computing, classical computing, quantum mechanics, qubits, quantum gates, superposition, entanglement, quantum algorithms, Shor’s algorithm, Grover’s algorithm, quantum programming, Qiskit, Cirq, quantum circuits, quantum hardware, error correction, cryptography, artificial intelligence, drug discovery, optimization, scalability, quantum noise, ethical implications, future directions
TERAPIA VISUAL E NEURODESENVOLVIMENTO NO TEA: REVISÃO INTEGRATIVA DE INTERVENÇÕES OPTOMÉTRICAS
Authors: Leal-Silva Leandro
Published: January 2025

A relação entre o Transtorno do Espectro Autista (TEA) e o desenvolvimento visual envolve desafios significativos na coordenação visual e integração sensorial, impactando o desempenho acadêmico e social das crianças. Este estudo revisou a literatura sobre intervenções optométricas, como o uso de prismas e terapia visual, destacando sua eficácia em melhorar as funções visuais e motoras, além de promover a modulação comportamental. Foram analisadas as principais estratégias de personalização das terapias, revelando que a abordagem integrada de optometristas, educadores e terapeutas é essencial para avanços na qualidade de vida dessas crianças. A revisão destacou o impacto positivo das terapias visuais no neurodesenvolvimento de crianças com TEA, evidenciando o potencial dessas intervenções para otimizar o desempenho escolar e social.
Hydrogel Based Controlled Drug Delivery for Psoriasis
Authors: Miss. Ghodake Simran S  , Prof. Nikam Harshada D  , Mr. Jathar Aniket G
Published: January 2025

Psoriasis is a chronic inflammatory skin disorder that affect millions of people worldwide . current treatments for psoriasis include topical corticosteroids , immunomodulators and phototherpy but these treatments may have limited efficacy or cause side effect . curcumin a natural compound with anti-inflammtory and antioxidant properties has been shown to have potential as an alternative treatment for psoriasis . however the low solubility and bioavailability of curcumin limit its effectiveness when administered orally or topically . curcumin hydrogel a topical formulation of curcumin has been developed to address these limitation . in this review we summarize the current research on the use of curcumin hydrogel in the treatment of psoriasis . we discuss the pharmacological properties of curcumin the formulation of curcumin hydrogel and the preclinical and clinical studies investigating the efficacy and safety of curcumin hydrogel in psoriasis . overall the available evidence suggests that curcumin hydrogel may be a promising alternative treatment for psoriasis with potential benefits in reducing inflammation , promoting wound healing, and improving overall quality of life for psoriasis patients . further research is needed to fully elucidate the mechanism of action curcumin hydrogel and to optimize its formulation and delivery for maximum efficacy.