bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Surface and Tropospheric Column Analysis of Sulfur Dioxide Variability at the Lamezia Terme WMO/Gaw Regional Station in Calabria, Southern Italy
Authors: D’Amico Francesco , Lo Feudo Teresa , Gullì Daniel , Ammoscato Ivano , De Pino Mariafrancesca , Malacaria Luana , Sinopoli Salvatore , De Benedetto Giorgia , Calidonna Claudia Roberta
Published: January 2025

Sulfur dioxide (SO2) can be of natural and anthropogenic origin and is one of the sulfur compounds present in the atmosphere. Among natural sources, volcanoes contribute with relevant annual outputs, and major eruptions lead to spikes in these outputs. In the case of anthropogenic pollution, SO2 emissions are mostly correlated with the sulfur content of fuels, which has been the focus of specific emission mitigation policies for decades. Following other examples of cyclic and multi-year evaluations, an analysis on SO2 at the Lamezia Terme (code: LMT) WMO/GAW (World Meteorological Organization – Global Atmosphere Watch) station in Calabria, Southern Italy was performed. The coastal site is characterized by wind circulation patterns that result in the detection of air masses with poor or enhanced anthropic influences. The presence of the Aeolian Arc of active, quiescent, and extinct volcanoes, as well as Mount Etna in Sicily, may influence LMT observations with diffused SO2 emissions. For the first time in the history of LMT, a multi-year analysis of a parameter has been integrated with TROPOMI data gathered by Sentinel-5P used to test total tropospheric column densities at the LMT itself and select coordinates in the Tyrrhenian and Ionian seas. Surface and satellite data indicate that SO2 peaks at LMT are generally linked to winds from the western-seaside wind corridor, a pattern that is compatible with active volcanism in the Tyrrhenian Sea and maritime shipping to and from the Gioia Tauro port located in the same region. The findings of this research provide the basis for enhanced source apportionment which could further differentiate anthropogenic sources in the area from natural outputs.
Information Geometric Framework for Point Cloud Analysis
Authors: Vishwakarma Amit , Moosath KS Subrahamanian
Published: January 2025

This paper introduces a novel method for comparing three dimensional point clouds, a critical task in various applications such as computer vision, pattern recognition etc. In this method, point cloud is interpreted as samples from an underlying probability distribution-Gaussian Mixture Model. Then, a rigorous mathematical foundation is established by proving that the space of Gaussian Mixture Models form a statistical manifold. The statistical manifold structure of Gaussian Mixture Model enables us to use the information geometric tools for similarity measure. The similarity or distance measures between Gaussian Mixture Models plays a crucial role in many applications. In this paper, the Modified Symmetric Kullback-Leibler Divergence is used for the similarity measure. This method of comparing the point clouds takes care of the geometry of the objects represented by the point clouds. The experimental result on comparison (i) of basic geometric shapes, (ii) of three-dimensional human body shapes within a comprehensive human body shape dataset, (iii) of animal shapes and (iv) of point clouds of same objects produced from the dense point clouds in Point Cloud Upsampling Adversarial Network dataset indicate that the information geometric method achieves superior performance compared with the state-of-the-art methods and valuable insights are derived from the results.
The Relationship Between Achievement Emotions and Engagement Among EFL Learners in the Post-Pandemic Era
Authors: Kuncoro Adhityo , Anam Syafi’ul , Wardhani Dyah Rhetno
Published: January 2025

Investigating students' perceptions of English learning is a topic that has received a lot of attention in the field of language education. The purpose of this study is to investigate the relationship between students' achievement emotions (enjoyment and anxiety) and their engagement in the post pandemic era. 30 participants are selected from two different classes in the informatics engineering department. This study used a quantitative approach to examine the relationship between students' achievement emotions and engagement levels. Data were collected through a Google Forms questionnaire, consisting of 19 items from the Foreign Language Enjoyment Scale (FLES), 8 items from the Foreign Language Classroom Anxiety Scale (FLCAS), and 15 items adapted from the Online English Learning Engagement (OELE) questionnaire, all measured with a five-point Likert scale. Descriptive analysis was conducted to summarize the data, and the results were analyzed using SPSS 27 to explore the relationships between emotions and engagement. The findings showed that (1) students’ enjoyment variable had significant effect towards students’ engagement (Sig. 0,001<0,05). Students’ enjoyment had positive correlation while students’ anxiety had negative correlation towards students’ engagement variable. (2) students’ enjoyment, specifically personal enjoyment had significant effect on students’ engagement. The conclusion is that educators recommend being more aware of their students' emotional states; considering enjoyment has important roles in language education, students' feelings of enjoyment should be increased, which may reduce degrees of apprehension and result in better language learning. An investigation of multimodal integration to reduce students’ anxiety could be a suggestion for the next research.
Optimizing the Role of Kiai in Preparing Competitive Santripreneurs
Authors: Hidayat Ahmad Agus , Buchori Imam , Arlina Agustin Mila , Muflihin Mohammad Dliyaul , Ashari Muhammad Rizki
Published: January 2025

Pesantren economics has increasingly gained attention from various circles, moving away from the traditional stigma of being solely traditional educational institutions. This article explores the role of the Kiai of Darul Pesantren, Menganti, in developing and preparing santripreneurs. This article employs qualitative research with a case study approach. Use the triangulation method. Data analysis was conducted through data reduction, data presentation, and verification. The validity of the findings was ensured through extended observation and methodological triangulation. The study's findings reveal that the role of the Kiai in preparing santripreneurs is carried out through several methods: a) Doctrination of students through the learning process, b) Aligning student's areas of expertise with their interests and talents, c) Establishing partnerships and collaborations with third parties, d) Incorporating santripreneurs education into extracurricular activities at the pesantren, e) Providing educational scholarships for students, f) Requiring all students to have savings in the pesantren through BMT (Baitul Maal wa Tamwil). On the other hand, the challenges faced include: a) A lack of motivation among students to learn entrepreneurship, b) Time constraints for both students and instructors, c) Limited entrepreneurial capital, and d) A shortage of human resources within the pesantren.
The Implementation of Fiqh Principle in Islamic Financial Products: A Systematic Literature Review
Authors: Ni'mah Nafisatu Roudlotin , Asmuni Asmuni
Published: January 2025

The fiqh rules aim to provide a foundation for all activities carried out by Muslims, including economic activities. Through the rules of fiqh, various contemporary economic problems can be solved by drawing a red thread from the arguments that have existed before. For example, the phenomenon of online buying and selling that is currently rife can be found by linking the arguments that can be used as a reference. This implementation must be done because, with it, Islamic economic activity will be easier to achieve its goals. The purpose of this study is to find out the application of the rules of fiqh in various Islamic financial products. The method used in this study is a systematic literature review by extracting several scientific journals related to the theme. The application of the rules of fiqh in various Islamic financial products has proven to be significant and has a positive impact from various economic sides. The application of the rules of fiqh makes all economic layers have a foundation in doing something so that it does not come out of the principles of Islamic sharia.
ANALISIS PERTIMBANGAN DAN PUTUSAN HAKIM DALAM PUTUSAN PENGADILAN TINGGI MEDAN NOMOR 159/pid/2023/PT MDN
Authors: Jomi Apriano Viktory , Michael Tomy
Published: January 2025

Penelitian ini bertujuan untuk menganalisis pertimbangan dan putusan hakim dalam kasus penyalahgunaan jabatan yang melibatkan seorang polisi, Aipda Leonardo Sinaga, dari Polrestabes Medan, yang mengakibatkan kematian seorang tahanan, Hendra Syahputra. Metode yang digunakan adalah metode normatif, yang menitikberatkan pada analisis terhadap peraturan-peraturan dan norma-norma hukum yang berlaku. Dalam penelitian ini, berbagai aspek seperti interpretasi hukum, analisis fakta, penerapan prinsip-prinsip hukum, bukti, argumen hukum, dan norma-norma yang berlaku akan ditelaah secara mendalam.
Hasil penelitian menunjukkan bahwa hakim mempertimbangkan berbagai faktor dalam membuat putusan, termasuk kronologi kejadian, alat bukti seperti Visum-Et Repertum, rekaman CCTV, bola karet yang dilapisi kain, dan keterangan saksi. Visum-Et Repertum mengungkapkan adanya luka memar luas dan perdarahan internal yang disebabkan oleh trauma tumpul. Rekaman CCTV memperlihatkan tindakan kekerasan berulang yang dilakukan terhadap korban. Berdasarkan analisis ini, putusan hakim menyatakan bahwa tindakan terdakwa menyebabkan kematian korban.
Kesimpulan penelitian ini menegaskan pentingnya integritas dan keadilan dalam putusan hakim. Dengan pertimbangan yang matang terhadap berbagai aspek hukum dan fakta yang ada, penelitian ini berkontribusi pada pemahaman yang lebih baik mengenai proses pembentukan putusan hakim dalam kasus penyalahgunaan jabatan, serta diharapkan dapat menjadi referensi bagi studi-studi hukum di masa mendatang untuk meningkatkan keadilan dalam sistem peradilan Indonesia.
keywords/kata kunci : pertimbangan hakim, putusan hakim, bukti hukum
PENYELESAIAN SENGKETA KONSUMEN DALAM TRANSAKSI JUAL BELI ONLINE MELALUI BADAN PENYELESAIAN SENGKETA
Authors: Fernanda Tasya Raden Roro , Astutik Sri , Handayati Nur , Nasoetion Deddi Wrdana
Published: January 2025

This study discusses legal protection for consumers in online buying and selling transactions and efforts to resolve disputes that occur due to default by business actors. In the digital era, online transactions are becoming increasingly popular because they are considered more practical and efficient. However, online shopping also has risks, such as goods that are not in accordance, late delivery, or even fraud. In Indonesia, legal protection for consumers in online transactions is regulated in Law Number 8 of 1999 concerning Consumer Protection and Law Number 1 of 2024 concerning Information and Electronic Transactions. Consumers who experience losses can file a lawsuit through the Consumer Dispute Resolution Agency (BPSK) or the court. This study uses a case study on the Shopee platform to analyze the effectiveness of BPSK in resolving consumer disputes. The results of the study show that BPSK is a more practical alternative than the courts in resolving consumer disputes. However, there are still many obstacles in its implementation, such as a lack of consumer understanding of the lawsuit filing procedure and the time-consuming and costly legal process. This study concludes that legal protection for consumers can be more effective if the government actively monitors online transactions and educates consumers about their rights. Efforts to resolve disputes through BPSK need to be improved to be more efficient and to meet consumer protection needs.
HAK POLITIK MANTAN NARAPIDANA DALAM PERSPEKTIF HAK POLITIK ISLAM
Authors: Surbakti Husnatul , Yuhermansyah Edi , Umur Azmil
Published: January 2025

Sistem demokrasi yang diterapkan di Indonesia memberikan ruang yang seluas-luasnya bagi masyarakat untuk turut serta membangun negara sesuai dengan tata pemerintahan yang baik. Luasnya kesempatan tersebut terangkum dalam syarat-syarat untuk terlibat langsung sebagai pemimpin atau wakil rakyat. Termasuk di dalamnya hak mantan narapidana untuk mengambil peran politik dengan berbagai batasan yang diatur oleh undang-undang untuk mengawasi keberlanjutan tanggung jawab mantan narapidana dalam mengambil hak politik. Dengan pendekatan analisis normatif, penelitian ini menguraikan tentang hak-hak politik bagi mantan narapidana khususnya dalam Putusan Mahkamah Konstitusi Nomor 03-03/PHU.DPD-XXII/2024. Hak politik yang diberikan oleh undang-undang kepada mantan narapidana merupakan masa jeda politik. Penelitian ini juga lebih jauh mengupas tentang masa jeda politik bagi mantan narapidana dari perspektif hak politik Islam. Menganalisis syarat-syarat yang dikemukakan oleh para fuqoha khususnya syarat untuk berlaku adil dan berakhlak mulia. Parameter etika moral merupakan modal seorang pemimpin dalam mengemban tanggung jawab sebagai pejabat publik.
Mediating effects of career planning on the relationship between self-understanding and career awareness and career decisions among low-income college students
Authors:   Soc Cognitive Enhancement Intervention, Kim Eunbin , Kim DaeBong
Published: January 2025

Objective: The purpose of this study is to examine the longitudinal mediating effect of career planning in the process by which self-understanding and career awareness influence career decision-making among university students.
Methods: Data from the Samsung Dream Scholarship Foundation’s longitudinal study on marginalized children and adolescents were utilized, specifically focusing on data from 280 students who participated in the “College Hope Scholarship” program in 2021 and 2022. The relationships among the variables were analyzed using Structural Equation Modeling (SEM).
Results: The findings of this study are as follows. First, career planning was found to have a partial mediating effect on the relationship between self-understanding and career decision-making. Second, career planning showed a full mediating effect in the relationship between career awareness and career decision-making.
Conclusions: These results suggest that to enhance career decision levels among university students, individuals need not only to understand themselves and improve their level of career awareness but also to develop and manage specific career plans. Therefore, it is proposed that both universities and society should provide education related to career planning to support students’ successful transition into society and their integration as professionals.
A Case Study of Multisystem Therapy for Improving Classroom Disruption Behavior and Parental Interaction in Adolescents with ADHD
Authors:   Soc Cognitive Enhancement Intervention, Seo Su Gyun
Published: January 2025

Purpose: This study is a single-case study of multisystemic therapy focusing on the problems of classroom disruptive behavior, peer bullying, disobedience to teachers, and negative interactions with mother in a middle-school boy with attention deficit hyperactivity disorder (ADHD).
Methods: Treatment was conducted over a seven-month period with a team of two counselors and one supervisor. Home visits were conducted weekly and included parenting coaching for the mother, social skills training for the child, and monitoring of the reward system. The evaluation included behavioral observation (counselor, teacher), K-CBCL (Korean-Child Behavior Checklist), TRF (Teacher's Report Form), and Parenting Stress Index (PSI). The intervention focused on a behavioral therapeutic approach to identify and improve environmental factors that contribute to problem behaviors, and weekly supervision meetings were held.
Results: First, classroom disruptive behavior, peer bullying, disobedience to teacher, and negative interactions with mother decreased. Second, compliance behaviors such as returning home before 10 p.m., going to bed at 12 p.m., waking up at 7 a.m., and speaking without anger increased. Third, there were positive changes in K-CBCL, TRF, and PSI.
Conclusion: The effectiveness of multisystemic treatment for ADHD children with externalizing problem behaviors was confirmed. It is suggested that multisystemic therapy can be proposed as an alternative to individual counseling which has limited effects on externalizing problem behaviors.
The Mediating Effects of Career Decision-Making Intrinsic Motivation and Career Maturity in the Relationship between High School Students’ Perceived Parental Rearing Attitudes and Career Preparation Behaviors
Authors:   Soc Cognitive Enhancement Intervention, Goo Ga Eun , Yeom Hye Seon
Published: January 2025

Objective: This study attempted to investigate the structural relationship between positive parenting attitude, career decision motivation, career maturity, and career preparation behavior for high school students.
Methods: To this end, a survey was conducted on 379 high school students (270 boys and 109 girls) in K city in Gyeongsangnam-do, and SPSS 20.0 and Amos 22.0 were used for data analysis.
Results: The results of this study are as follows. First, positive parenting attitude, career decision motivation, career maturity, and career preparation behavior, positive parenting attitude had a positive significant effect on career decision motivation and career maturity, but did not have a significant effect on career preparation behavior. In addition, career decision-making motivation and career maturity had a positive and significant effect on career preparation behavior. Second, positive parenting attitude and career preparation behavior, the significant mediating effect of career decision motivation and career maturity was confirmed.
Conclusions: This study is significant in that it confirmed that parents’ positive parenting attitude influences career adaptation.
Preoperative and postoperative factors causing the erectile dysfunction after bladder neck and nerve sparing robot-assisted laparoscopic radical prostatectomy
Authors: Sarikaya Selcuk , Ebiloglu Turgay , Buyantemur Mehmet , Inal Halil , Bedir Selahattin
Published: January 2025

Prostate cancer (PCa) is a prevalent disease with good prognosis and approximately 100% disease-specific survival rate is observed for the patients with localized cancer that treated with radical prostatectomy. According to the treatment options, complications may also be seen and the most common complications are urinary incontinence and erectile dysfunction. In our study, preoperative and postoperative factors affecting erectile functions after bladder neck and nerve-sparing robot assisted laparoscopic radical prostatectomy. Between October 2016 and October 2023, a total of 500 patients had bladder neck and nerve sparing robotic radical prostatectomy. Preoperative and postoperative factors related with the erectile functions have been evaluated in detail. Before operations; age, comorbidity status (cigarette smoking, hypertension, diabetes mellitus, additional illnesses), total PSA, free PSA, free/total PSA ratio, RDE findings, Prostate MRI findings, PSA density using the MRI, CFPB results, staging results were also noted. After operations; pathology results, control PSA results, need for additional treatments, continuing control PSA results after the additional treatments were noted. The age, lymphovascular invasion at CFPB, perineural invasion and surgical margin positiveness at postoperative pathology were detected to be important possible factors for the cause of postoperative ED. There was also significant correlation between the surgical margin positiveness and perineural invasion at the postoperative pathology reports (p = 0.001) showing the neural invasion of the tumor.Postoperative ED is an important factor that must be considered in both preoperative and postoperative period. Factors associated with postoperative ED must be evaluated in detail in order to avoid ED and also postoperative ED must be treated with effective treatment modalities that have been described in the literature.
LPS-induced extracellular AREG triggers macrophages pyroptosis through EGFR/TLR4 signaling pathway
Authors: Yuan Gang , Qiao Qudi , Jiang Aolin , Jiang Zeihui , Luo Haihua , Huang Lin , Wang Yanjie , Jiang Yong
Published: January 2025

Amphiregulin (AREG), as another EGF family member, is anchored to the cell surface as a transmembrane protein. In response to external stimulus, its extracellular domain can be release to extracellular matrix in a paracrine or autocrine manner. However, what it plays in septic macrophages pyroptosis remain poorly understood. The role of extracellular AREG was investigated in septic macrophages, mice as well as patients. Here, we found that AREG highly expressed in sepsis increased the expression of IL-6 protein and the expression of Caspase 1, IL-1β, Nlrp3 mRNA, resulting in macrophages pyroptosis. Mechanistically, macrophages pyroptosis was aggravated by extracellular AREG pretreatment and triggered by extracellular AREG and ATP (Adenosine 5'-triphosphate). The neutralizing antibody to AREG reduced LPS-induced EGFR activation, TLR4 expression and pyroptosis. Extracellular AREG-induced macrophages pyroptosis was decreased after applying inhibitions of EGFR and NF-κB as well as knockouts of TLR4 and Myd88. Besides, oxidative extracellular AREG promotes macrophages pyroptosis. In vivo studies reveal that extracellular AREG attenuates systemic inflammation infiltration and delays animal death in septic mouse model. Furthermore, serum AREG was associated with the immune inflammatory mediator, severity and mortality rate of septic patients, and genes of AREG-mediated pyroptosis signaling pathway were highly expressed in severe patients compared normal and general septic patients. Overall, extracellular AREG aggravated or triggered macrophages pyroptosis through EGFR/TLR4/Myd88/NF-κB signaling pathway, which provided promising treatment strategies for sepsis.
Exploring the factors associated with unmet need for family planning in settings with highest prevalence in Egypt
Authors: Oraby Doaa , Mowafy Maha , Jat Tej Ram , Amin Tarek Tawfik
Published: January 2025

Background: Despite efforts made to expand access to family planning (FP) services, a significant proportion of currently married women in rural Upper Egypt still has an unmet need for FP. The current study sought to understand the reasons behind the unmet need for FP in two settings with highest prevalence.
Study design: The study adopted qualitative methodology including focus group discussions with 48 women with unmet need for FP and in-depth interviews with ten service providers in Assuit and Souhag Governorates, both located in upper Egypt. Data were transcribed and the transcripts were analyzed using thematic analysis.
Results: Norms and traditions favoring many children per family especially sons result in family opposition to contraceptive use, specifically the husbands and mothers-in-law. Experiencing side effects and fear of health-related consequences of contraceptive use linked to prevalent myths stand out as potential reasons for unmet need.
Conclusion: The study highlighted the gap in communication activities to defy the myths related to contraceptives and the need to focus on counseling provided by the service providers to include proper use of FP methods, potential side effects and how to deal with them instead of discontinuing contraceptive methods or refrain using them.
Nonlinear coupled vibration and control of roll system for twenty- high rolling mill
Authors: He Dongping , Duan Ziheng , Xu Huidong , Kong Xianglan , Liu Yuanming , Wang Tao
Published: January 2025

Precision ultra-thin strips with high precision, corrosion resistance, excellent surface finish and other properties are widely used in micro-manufacturing, microelectronics, and other high-tech fields. The vibration characteristics of twenty-high rolling mills significantly affect the surface quality of extremely thin strips. In this study, a coupled nonlinear dynamic model of a twenty-high rolling mill with linear damping and nonlinear stiffness between the roll and strip was established. The amplitude-frequency equations of the primary, secondary, and internal resonances were obtained using the multi-scale method. The influence of different parameters on the amplitude-frequency curves was analyzed. According to Lyapunov's first approximation stability criterion, the stability of the roll system was analyzed using a moving phase plane phase trajectory diagram. A tuned mass damper was designed to control the nonlinear vibration characteristics of the twenty-high rolling mill, and a coupling dynamics model between the tuned mass damper and the roll system was established. The influences of the mass, stiffness, and damping ratios on the dynamic magnification coefficient of the roll were analyzed. To minimize the peak value of the dynamic amplification coefficient, an adaptive genetic algorithm was used to optimize the parameters of the tuned mass damper, and the optimal mass, stiffness, and damping ratios were determined. Finally, the feasibility and effectiveness of the tuned-mass damper were verified using time-domain, phase, and Poincare section diagrams, which provide an important reference values and theoretical basis for the design and analysis of the roll system for the twenty-high rolling mill.
Genetic Polymorphisms in Arsenic Metabolism and Oxidative Stress Genes Linked to Increased Cardiovascular Disease Risk in Arsenic Exposed Bangladeshi Population
Authors: Guha Partha , Nowshin Anika , Chowdhury Rahee Hasan , Alam Md. Jibran , Datta Amit , Shawon Inzamamul Ismail , Bhattacharjee Amlan , Wali Fahmida Binta , Hosain Nazmul , Maruf Mohammad Fazle , Rahman Md. Zillur , Khaleda Laila , Al-Forkan Mohammad
Published: January 2025

Arsenic (As) contamination in Bangladesh is a pervasive and insidious public health concern, with chronic exposure through water and food linked to a spectrum of health disorders, including cardiovascular diseases (CVD). Genetic polymorphisms in arsenic metabolism (AS3MT) and oxidative stress genes (SOD2, NOS3) can substantially impact the cardiovascular consequences of arsenic toxicity in humans. In our current study, we wanted to examine whether cardiovascular diseases were associated with arsenic exposure and single nucleotide polymorphisms (SNPs) of AS3MT, SOD2 and NOS3 genes in Bangladeshi population. A total of 43 patients who went through open heart surgery and from documented arsenic-contaminated and uncontaminated areas of Chittagong and Dhaka regions were selected for this study. We observed significantly higher (P = 0.042) nail As-concentration in patients from As-affected areas and histopathology indicated significantly greater cardiac tissue injury (P = 0.033) among these As-exposed patients compared to the unexposed ones. Our genotypic analysis showed a significant association of GA genotype of AS3MT rs10748835 (P = 0.022), CA genotype of SOD2 rs2758331 (P = 0.037), TC genotype of SOD2 rs2758334 (P = 0.026), GA genotype of NOS3 rs3918181 (P = 0.036), GA genotype (P = 0.024) and AA genotype of NOS3 rs2853792 (P = 0.018) with As-induced CVD. Additionally, haplotypic analysis showed AS3MT haplotype CGAA (P = 0.0006), SOD2 haplotype CTA (P = 0.028) and ACT (P = 0.0056) and NOS3 haplotype ACA (P = 0.0197) were significantly higher in frequency among the As-exposed patient group while, AS3MT haplotype CCAA (P = 0.03) and SOD2 haplotype CCT (P = 0.0024) and ATA (P = 0.00074) showed a significantly lower frequency among the same patient group. Our findings suggest that cardiovascular diseases development may be associated with arsenic intoxication and genetic polymorphisms of AS3MT, SOD2 and NOS3 genes in Bangladeshi population.
MiR-30c-5p targets SIRT1 to promote apoptosis in ovarian granulosa cells
Authors: Zhou Lifei , Zheng Bo , Luo Yan , Zhang Pingping , Dai Fangfang , Zhang mingming , Li Yali
Published: January 2025

Background: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by abnormal follicular development and is the leading cause of infertility among women of reproductive age. miR-30c-5p, a newly discovered microRNA (miRNA), plays a crucial role in numerous pathological conditions, such as malignancies, reproductive dysfunctions, and metabolic irregularities. However, the role of miR-30c-5p in PCOS and the apoptosis of granulosa cells (GCs) is not fully understood.
Research methods: GCs were isolated from the follicular fluid of 23 patients with PCOS and 21 normal controls. The expression of miR-30c-5p and Sirtuin 1 (SIRT1) was detected using quantitative real-time polymerase chain reaction (qRT-PCR). A Spearman correlation analysis was conducted to evaluate the relationship between the expression levels of these markers. Proliferation and apoptosis in human granulosa tumor cell lines (KGN) were analyzed following the overexpression or underexpression of miR-30c-5p, utilizing the Cell Counting Kit-8, flow cytometry, and western blot techniques. TargetScan was used to identify potential targets of miR-30c-5p, which were subsequently validated through qRT-PCR, western blot, and a dual luciferase reporter gene assay.
Results: The results of our study suggest that the levels of miR-30c-5p aresignificantly elevated in individuals with PCOS compared with the control group. Conversely, we observed a significant decrease in the expression of SIRT1 in patients with PCOS compared with the control group. Moreover, miR-30c-5p expression was negatively correlated with SIRT1. The upregulation of miR-30c-5p suppressed the expression of SIRT1 and Bcl-2, inhibited GC proliferation, and increased the expression of Bax.
Conclusion: Our findings suggest that miR-30c-5p inhibits the proliferation of KGN cells by targeting SIRT1. Thus, this study enhances the current understanding of the mechanisms underlying apoptosis in PCOS and GCs.
Assessing the Effectiveness of International Climate Agreements in Mitigating Global Warming
Authors: Mravcová Anna
Published: January 2025

This paper provides an in-depth evaluation of the effectiveness of international climate agreements in addressing the issue of global warming. As concern about climate change increase, global collaboration has become crucial in designing and implementing strategies to reduce emissions of greenhouse gases. The study reviews major international agreements, including the Kyoto Protocol, the Paris Agreement, and the subsequent Kyoto Climate Agreement, exploring their internal mechanisms, goals, and results. Drawing on empirical data, it assesses how well these agreements have performed in real life as regards limiting the global warming. The paper also discusses the challenges and obstacles in the process of implementing the agreements, such as compliance difficulties, political hurdles, and the involvement of various stakeholders. By synthesizing current research and policy insights, the paper aims to enhance public understanding of the effectiveness of these agreements and provides recommendations for improving their impact in tackling the urgent threat of climate change.
Agroecology in Brazil and Italy: Comparative Analysis of the Historical Formation Process of Agroecology
Authors: Michelato Ghizelini André Augusto , Pacini Gaio Cesare
Published: January 2025

The agroecological movement emerges as an alternative to modern agriculture and the conventionalization of organic farming. It advocates for the development of agri-food systems grounded in the principles of biodiversity, the strengthening of family farming, food sovereignty, and the reconnection between rural and urban areas. Understanding agroecological experiences worldwide is essential for evaluating their progress in building sustainable agroecosystems. This article aims to comparatively analyze the development of agroecology in Brazil and Italy, highlighting similarities and differences. In Italy, 19.68% of agricultural land is dedicated to organic production, compared to only 0.4% in Brazil—a difference of 49 times. Furthermore, 8.31% of Italian farms are organic, while in Brazil, the figure is only 1.28%. Both countries have followed different paths: in Brazil, the agroecological movement became consolidated in the 1990s, driven by the involvement of NGOs and family farmers. In contrast, in Italy, the movement gained momentum in 2015, with greater engagement from the scientific community. In Italy, agroecology developed within a context dominated by organic farming, whereas in Brazil, the agroecological movement preceded the institutionalization of organic agriculture.
Synthetic Strategies and Pharmacological Significance of Pyridine
Thiadiazole Derivatives: A Contemporary Overview
Authors: Kurup Rishi R. , Mishra Rakhi , Mazumder Rupa , Mazumder Avijit , Singh Gurvinder , Mishra Rashmi
Published: January 2025

In pharmaceutical research and drug design, five-membered heteroaromatic ring-fused
pyridine derivatives are becoming more common. The pyridine moiety is prone to ring fusion and
substitution because it is basic, soluble in water, stable, and able to establish hydrogen bonds. Because
of their diverse variety of biological actions, pyridine and thiadiazole have become intriguing possibilities
in medicinal chemistry. The water solubility of pharmaceutically promising compounds is often
improved by pyridine scaffolds with low basicity, which has also contributed to the development of
several broad-spectrum medicinal medicines. Considering these, this manuscript offers a thorough
investigation of the synthesis and variety of biological activities displayed by derivatives of pyridine
thiadiazole derivatives. The manuscript summarizes different synthetic approaches utilized in the synthesis
of these fused compounds and provides insight into their possible pharmacological uses by conducting
a comprehensive assessment of recent literature. The complex relationship between biological
significance and chemical synthesis provides novel treatment approaches and medication development
opportunities.
Exploratory Study on Motivational Factors in Recreational Sports: A Gender and Region-based Analysis of Students at Vietnam National University, Ho Chi Minh City
Authors: Ha Minh Diu , Dao Chanh Thuc
Published: January 2025

Introduction

The importance of recreational sports for overall human development is widely acknowledged. These activities provide numerous physical, mental, and social benefits, particularly for students. Problem Statement: While the general benefits of recreational sports are recognized, less is understood about the specific motivational factors driving student participation, particularly concerning the influence of gender and regional background. This study addresses this gap by investigating how these factors shape students' motivation to engage in recreational sports.

Methods

This study focuses on understanding the motivational factors influencing recreational sports participation among students at Vietnam National University - Ho Chi Minh City (VNU-HCMC), specifically examining the role of gender and regional background. Material and Methods: The research involved a sample of 918 students (455 males and 463 females) aged 18-22 from VNU-HCMC. Motivation was measured using the standardized ATPA-D questionnaire.

Results

The findings revealed that health, enjoyment, and social interaction are the three primary motivators for students' participation in recreational sports. However, significant differences were observed among subgroups. Male students prioritized social interaction, while female students placed higher importance on health benefits. Interestingly, aesthetics was a more significant motivator for female students from the North compared to those from the South and Central regions. The competitive aspect was more appealing to male students from the South. This trend was mirrored among female students, with those from the South and Central regions showing greater interest in competition than those from the North. Discussion: Despite the observed gender and region-based differences, the study also highlights similarities in recreational sports participation motives among young people across Vietnam. This suggests that regional background is not the sole determinant of recreational sports choices among VNU-HCMC students.

Conclusion

The study provides valuable insights into the diverse motivational factors influencing recreational sports participation among students. Understanding these factors, particularly the nuances related to gender and regional background is crucial for promoting and developing inclusive and engaging recreational sports programs.
Assessment of Reliability and Validity of Celiac Disease–Related YouTube Videos: Content Analysis
Authors: Polat Yunus Halil , Cankurtaran Rasim Eren
Published: January 2025

Background

YouTube is an increasingly used platform for medical information. However, the reliability and validity of health-related information on celiac disease (CD) on YouTube have not been determined.

Objective

This study aimed to analyze the reliability and validity of CD-related YouTube videos.

Methods

On November 15, 2023, a search was performed on YouTube using the keyword “celiac disease.” This search resulted in a selection of videos, which were then reviewed by 2 separate evaluators for content, origin, and specific features. The evaluators assessed the reliability and quality of these videos using a modified DISCERN (mDISCERN) score, the Journal of the American Medical Association (JAMA) benchmark criteria score, the usefulness score, video power index (VPI), and the Global Quality Scale (GQS) score.

Results

In the analysis of 120 initially screened CD videos, 85 met the criteria for inclusion in the study after certain videos were excluded based on predefined criteria. While the duration of the videos uploaded by health care professionals was significantly longer than the other group (P=.009), it was concluded that the median scores for mDISCERN (4, IQR 4-5 vs 2, IQR 2-3; P<.001), GQS (4, IQR 4-5 vs 3, IQR 2-3; P<.001), JAMA (4, IQR 3-4 vs 2, IQR 2-3; P<.001), and usefulness (8, IQR 7-9 vs 6, IQR 3-6; P<.001) of the videos from this group were significantly higher than those from non–health care professionals. Video interaction parameters, including the median number of views, views per day, likes, dislikes, comments, and VPI, demonstrated no significant difference between the 2 groups.

Conclusions

This study showed that YouTube videos about CD vary significantly in reliability and quality depending on their source. Increasing the production of reliable videos by health care professionals may help to improve patient education and make YouTube a more reliable resource.
Unpacking Performance Factors of Innovation Systems and Studying Germany’s Attempt to Foster the Role of the Patient Through a Market Access Pathway for Digital Health Applications (DiGAs): Exploratory Mixed Methods Study
Authors: Gehder Sara , Goeldner Moritz
Published: January 2025

Background

Health care innovation faces significant challenges, including system inertia and diverse stakeholders, making regulated market access pathways essential for facilitating the adoption of new technologies. The German Digital Healthcare Act, introduced in 2019, offers a model by enabling digital health applications (DiGAs) to be reimbursed by statutory health insurance, improving market access and patient empowerment. However, the factors influencing the success of these pathways in driving innovation remain unclear.

Objective

This study aims to identify the key performance factors of the innovation system shaped by the patient-relevant structural and procedural improvement (pSVV) pathway within the DiGA model. By examining how this pathway supports the entry of innovative digital health technologies, we seek to uncover the systemic dynamics that influence its effectiveness in fostering patient-centered digital health solutions.

Methods

This study, conducted from May 2023 to November 2024, used a mixed methods approach. A descriptive analysis assessed how DiGA manufacturers use positive health care effects, giving a market overview of the pSVV technology. A qualitative analysis using grounded theory and Gioia methodology provided insights into stakeholder perspectives, focusing on manufacturers and regulatory bodies. A functional-structural analysis examined how components of the innovation system, such as actors, institutions, interactions, and infrastructure, interact and impact the effectiveness of the pathway.

Results

The descriptive analysis showed that only 11 (20%) of the 56 DiGAs available in Germany used the pSVV pathway, with only 1 (2%) provisionally listed DiGA using pSVV as a primary end point; 6 of 9 (67%) pSVV key areas were used. The qualitative analysis revealed that manufacturers prioritize demonstrating medical benefits over pSVV due to evidence requirements and uncertainties around pSVV acceptance. Operational barriers hindered the adoption of pSVV, despite a positive reception among stakeholders. The systemic analysis identified key issues, including a lack of entrepreneurial focus on pSVV, limited regulatory experience, inadequate measurement methods, and entrenched practices prioritizing medical benefits, that hinder market formation and legitimacy.

Conclusions

This study identifies key factors for effectively implementing innovation systems through regulated market access pathways, including content and format security, clearer framework specification, active innovation process management, and market formation stimulation. Addressing these factors can reduce uncertainties and promote wider adoption of digital health technologies. The findings highlight the need for future research on patient empowerment and the development of methodologies beyond traditional therapeutic outcomes.
Application progress of Ecological Momentary Assessment technology in health management platform (Preprint)
Authors: 张 笑笑 , 吴 觅之 , 王 佳楠 , 傅 若涵 , 潘 红英
Published: January 2025

UNSTRUCTURED

To explore the application progress of ecological momentary assessment technology in health management platform, aiming to provide reference for the construction of health management platform based on ecological momentary assessment technology in medical care field. At present, the open source frameworks that can meet the ecological momentary assessment function in the health management platform include Emu framework, AWARE framework and schema framework. The platform structure is roughly divided into presentation layer, logical layer, database layer and service layer (third-party layer). The platform can use ecological momentary assessment to collect various data, evaluate specific content and promote the intervention process. Researchers should regularly instruct patients on how to use and maintain the device, design the platform in conjunction with programmers, service providers, and regulators to jointly develop measures to ensure data security, and continuously upgrade the platform to reduce the burden of patient use and improve patient compliance.
Optimasi Regenerasi Kalus Embriogenik Porang (Amorphophallus muelleri Blume) Melalui Kultur Suspensi Sel Menggunakan BAP (Benzyl Amino Purin)
Authors: Restanto Didik Pudji , Prayoga Mohammad Candra , Arsyika Izna , Farlisa Veronenci Yuliarbi , Hardjo Popy Hartatie
Published: January 2025

Porang Amorphophallus muelleri Blume merupakan tanaman umbi-umbian yang banyak dimanfaatkan sebagai bahan kosmetik dan diekspor untuk bahan baku industri. Perbanyakan porang secara konvensional mengalami masa dormansi. Perbanyakan porang melalui kultur jaringan dapat menghasilkan bibit yang cepat dan dalam jumlah yang banyak. Kultur jaringan porang dapat melalui somatik embriogenesis melalui pembentukan kalus dan poliferasi kalus dengan kultur suspensi sel. Optimasi regenerasi kalus hasil poliferasi kultur suspensi sel sangat penting untuk menunjang keberhasilan perbanyakan porang secara masal. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi BAP terhadap regenerasi kalus embriogenik porang Amorphophallus muelleri B. hasil kultur suspensi. Penelitian menggunakan rancangan acak lengkap dengan faktor konsentrasi BAP yang terdiri dari 4 taraf perlakuan antara lain 1 mg.L-1, 2 mg.L-1, 3 mg.L-1, dan 4 mg.L-1. Setiap perlakuan diulang sebanyak 5 ulangan. Analisis data penelitian menggunakan ANOVA dan uji lanjut dengan DMRT pada taraf kesalahan 5%. Analisis data menggunakan aplikasi SPSS statistics versi 26. Berdasarkan hasil penelitian, perlakuan BAP 1 mg.L-1menunjukkan hasil terbaik dengan parameter kedinian munculnya tunas tercepat 45 hst, tunas terpanjang 7.6 cm, jumlah tunas terbanyak 7,33 tunas, dan persentase regenerasi 93,33%. Berdasarkan pengamatan histologi, kalus embriogenik berkembang menghasilkan mature embrio yang lebih banyak sehingga dapat menginduksi tunas yang banyak.
Rare Case of Oncocytic Carcinoma of Thyroid: Successful Surgical Management of a Large 20 Cm Tumor
Authors: Vardhanan Dr. Govindaraj , Sasipriya Dr. Ponniah , Dr. Gunasekaran  , Mallika Dr. A. , Murugavel Dr. Hareni
Published: January 2025

Oncocytic carcinoma of the thyroid (OTC), also known as Hürthle cell carcinoma (HCC), is an extremely rare diagnosis accounting for 3% to 5% of all thyroid cancers. Historically, Hürthle cell carcinoma was considered as a variant of follicular carcinoma because of its origin in the follicular epithelium. However, later reports suggested that they are more aggressive, and most cases were found to be refractory to Radioiodine ablation (RAI). The rarity of HCC and the historical overlap with follicular thyroid cancer has made it difficult to develop Hürthle cell carcinoma-specific management strategies. Management varies based on tumor size and extent, with total thyroidectomy being recommended for larger tumors. The role of radioactive iodine therapy remains controversial. In this report, we present a 71-year-old female who presented to our hospital with a massive (20 cm) thyroid tumor that was diagnosed as oncocytic carcinoma of the thyroid and was successfully managed with total thyroidectomy.
The Effect of Wall Materials and Drying Methods on The Encapsulation Sardinella lemuru Smart Flavor
Authors: Azkiyah Lailatul , Witono Yuli , Taruna Iwan , Choiron Miftahul , Wahyuni Livia , Nafi' Ahmad , Belgis Maria , Masahid Ardiyan Dwi , Aini Anggita Arifatul
Published: January 2025

Antioxidant compounds in food are generally less stable when applied to food, so technology is needed to help antioxidant compounds become more stable during storage, one of which is microencapsulation. The research aims to determine the effect of the wall material ratio and drying methods on the characteristics of Sardinella lemuru smart flavor microcapsules. The experimental design used was a two-factor Complete Random Design (CRD): ratio of wall materials (maltodextrin: Arabic gum) and drying methods (spray drying and freeze drying). The research showed that enzyme activity ranged from 14.81-52.64 U/mL; lightness 95.2-100; yield 4.00-17.19%; water content 2.26-9.15%; antioxidant activity 15.75-31.23%; encapsulation efficiency 69.06-78.47%. Microcapsules with the highest water content, lightness, antioxidant activity, and encapsulation efficiency were at the ratio wall materials (maltodextrin: Arabic gum) of 7:3 by spray drying, 9.15%, 100, 31.23%, and 78.47%. On the other hand, the highest yield (17.19%) was at the ratio wall materials (maltodextrin: Arabic gum) 8:2 by freeze-drying. The morphology of the microcapsules by spray drying is spherical, and freeze drying makes it flaky and sharp.