bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating tumor cells as a preoperative risk marker for occult metastases in patients with resectable cholangiocarcinoma
Authors: Fründt Thorben , von Felden Johann , Krause Jenny , Heumann Asmus , Li Jun , Riethdorf Sabine , Pantel Klaus , Huber Samuel , Lohse Ansgar W. , Wege Henning , Schulze Kornelius
Published: November 2022

Cholangiocarcinoma (CCA) is an aggressive tumor associated with a high rate of recurrence after resection. An important risk factor for recurrence is the presence of occult metasta-ses, which are not radiologically detectable at the time of diagnosis. There are currently no biomarkers for the preoperative assessment of micrometastases. A previous study demonstrated the prognostic relevance of circulating tumor cells (CTC) in patients with advanced CCA but the potential of CTCs as a preoperative marker for detecting occult metastases has not been investigated so far. In this two-phase study, we first recruited a cohort of 27 patients with histologically proven, metastatic CCA or gallbladder cancer (GBCA) to assess feasibility (feasibility cohort, FC). CTCs were measured in the peripheral blood using the CellSearch System (CSS) between October 2012 and January 2017. Subsequently, in 11 patients undergoing curative-intended resection for CCA (intrahepatic CCA: n =4; extrahepatic CCA n= 6; gallbladder cancer: n=1), peripheral and central venous blood specimens were obtained to improve detection rate by simultaneous measurement and to elucidate distribution of CTCs in different venous compartments. Presence of CTCs detection was correlated with postoperative TNM-status.

In the FC, CTCs (range 1-3 cells, median: 1) were detected in 40% (11/27) patients and were signifi-cantly associated with worse overall survival (hazard ratio: 3.59; 95% CI: 1.79- 7.1; p = 0.04). By combined peripheral and central measurement, CTC detection was increased to 54% (6/11) in the resection cohort (RC) and was associated with metastases that were only identified during the surgical procedure (peritoneal carcinoma: n = 1; infiltration of the duodenum: n = 1) or immediately after surgery (evidence of pulmonary metastases by CT scan two days after resection, not evident on initial tumor staging prior resection). Taken together, in this single center pilot study, we demonstrated that CTCs are detectable in CCA patients and are associated with significantly impaired survival in patients at metastatic stage. Detection rate prior to surgery was improved to >50% by combined peripheral and central measurement. Moreover, preoperative CTC detection may indicate existing metastases and could help to stratify patients more accurately.
Therapeutic drug monitoring in oncology - What’s out there: A bibliometric evaluation on the topic
Authors: Stojanova Jana , Carland Jane E. , Murnion Bridin , Seah Vincent , Siderov Jim , Lemaitre Florian
Published: November 2022

Pharmacological therapy is the mainstay of treatment for cancer patients. Despite wide interpatient variability in systemic drug concentrations for numerous antineoplastics, dosing based on body size remains the predominant approach. Therapeutic drug monitoring (TDM) is used for few antineoplastics in specific scenarios. We conducted a rapid bibliometric evaluation of TDM in oncology to capture a snapshot of research in this area over time and explore topics that reflect development in the field. Reports with the composite, indexed term ‘therapeutic drug monitoring’ in the title and abstract were extracted from MEDLINE (inception to August 2021). Reports related to applications in cancer were selected for inclusion and were tagged by study design, antineoplastic drugs and concepts related to TDM. We present a timeline from 1980 to the present indicating the year of first report of antineoplastic agents and key terms. The reports in our sample primarily reflected development and validation of analytical methods with few relating to clinical outcomes to support implementation. Our work emphasises evidence gaps that may contribute to poor uptake of TDM in oncology.
2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli
Authors: Korycka-Machała M. , Kawka M. , Lach J. , Płocińska R. , Bekier A. , Dziadek B. , Brzostek A. , Płociński P. , Strapagiel D. , Szczesio M. , Gobis K. , Dziadek J.
Published: November 2022

It was recently reported that 4-substituted picolinohydrazonamides carrying hydrophilic cyclic amines, such as morpholine and pyrrolidine, at the end of their thiosemicarbazide chain have potent antimycobacterial activity in vitro at concentrations below 1 μg/ml. Here, two selected compounds, 2,4-disubstituted pyridine derivatives 11 and 15, revealed significant bactericidal activity against Mycobacterium tuberculosis localized intracellularly within human macrophages, as well as against biofilm-forming tubercle bacilli. Mutants were selected that were resistant to the investigated compounds at an efficiency similar to that identified in the presence of the first line antituberculosis drug rifampicin. The resistant mutants were viable in the presence of the tested compounds exclusively on solid media. Genome-wide sequencing of the mutants selected in the presence of compound 11 revealed the accumulation of nonsynonymous mutations in the mmpR5 gene encoding a transcriptional repressor of the MmpS5-MmpL5 efflux pump, whose upregulation has been associated with bedaquiline resistance. The depletion of MmpR5 in wild-type M. tuberculosis using CRISPR–Cas9 technology increased the resistance of this strain to compound 11. Mass spectrometry-based proteomics (LC–MS/MS) of wild-type tubercle bacilli growing in subinhibitory concentrations of compounds 11 or 15 revealed 15 overproduced proteins not detectable in the control cells, including virulence-related proteins.
Exploring a four-gene risk model based on doxorubicin resistance-associated lncRNAs in hepatocellular carcinoma
Authors: Zhang Zunyi , Chen Weixun , Luo Chu , Zhang Wei
Published: November 2022

Background: Liver cancer is a lethal cancer type among which hepatocellular carcinoma (HCC) is the most common manifestation globally. Drug resistance is a central problem impeding the efficiency of HCC treatment. Long non-coding RNAs reportedly result in drug resistance. This study aimed to identify key lncRNAs associated with doxorubicin resistance and HCC prognosis.

Materials and Methods: HCC samples with gene expression profiles and clinical data were accessed from public databases. We applied differential analysis to identify key lncRNAs that differed between HCC and normal samples and between drug-fast and control samples. We also used univariate Cox regression analysis to screen lncRNAs or genes associated with HCC prognosis. The least absolute shrinkage and selection operator (LASSO) was used to identify the key prognostic genes. Finally, we used receiver operating characteristic analysis to validate the effectiveness of the risk model.

Results: The results of this study revealed RNF157-AS1 as a key lncRNA associated with both doxorubicin resistance and HCC prognosis. Metabolic pathways such as fatty acid metabolism and oxidative phosphorylation were enriched in RNF157-AS1-related genes. LASSO identified four protein-coding genes—CENPP, TSGA10, MRPL53, and BFSP1—to construct a risk model. The four-gene risk model effectively classified HCC samples into two risk groups with different overall survival. Finally, we established a nomogram, which showed superior performance in predicting the long-term prognosis of HCC.

Conclusion: RNF157-AS1 may be involved in doxorubicin resistance and may serve as a potential therapeutic target. The four-gene risk model showed potential for the prediction of HCC prognosis.
Purine metabolism-related gene expression signature predicts survival outcome and indicates immune microenvironment profile of gliomas
Authors: Chen Siliang , Zhang Shuxin , Wang Zhihao , Li Junhong , Yuan Yunbo , Li Tengfei , Zuo Mingrong , Feng Wentao , Li Wenhao , Chen Mina , Liu Yanhui
Published: November 2022

Glioma is the most common malignant tumor in the central nervous system. The impact of metabolism on cancer development and the immune microenvironment landscape has recently gained broad attention. Purines are involved in multiple metabolic pathways. It has been proved that purine metabolism could regulate malignant biological behaviors and response to immune checkpoint inhibitors in multiple cancers. However, the relationship of purine metabolism with clinicopathological features and the immune landscape of glioma remains unclear. In this study, we explored the relationships between the expression of purine metabolism-related genes (PuMGs) and tumor features, including prognosis and microenvironment of glioma, based on analyses of 1,523 tumors from 4 public databases and our cohort. Consensus clustering based on 136 PuMGs classified the glioma patients into two clusters with significantly distinguished prognosis and immune microenvironment landscapes. Increased immune infiltration was associated with more aggressive gliomas. The prognostic Purine Metabolism-Related Genes Risk Signature (PuMRS), based on 11 critical PuMGs, stratified the patients into PuMRS low- and high-risk groups in the training set and was validated by validation sets from multiple cohorts. The high-risk group presented with significantly shorter overall survival, and further survival analysis demonstrated that the PuMRS was an independent prognostic factor in glioma. The nomogram combining PuMRS and other clinicopathological factors showed satisfactory accuracy in predicting glioma patients’ prognosis. Furthermore, analyses of the tumor immune microenvironment suggested that higher PuMRS was correlated with increased immune cell infiltration and gene expression signatures of “hotˮ tumors. Gliomas in the PuMRS high-risk group presented a higher expression level of multiple immune checkpoints, including PD-1 and PD-L1, and a better-predicted therapy response to immune checkpoint inhibitors. In conclusion, our study elucidated the relationship between the expression level of PuMGs and the aggressiveness of gliomas. Our study also endorsed the application of PuMRS to construct a new robust model for the prognosis evaluation of glioma patients. The correlations between the profiles of PuMGs expression and tumor immune microenvironment potentially provided guidance for immunotherapy in glioma.
Formulation of water-soluble Buddleja globosa Hope extracts and characterization of their antimicrobial properties against Pseudomonas aeruginosa
Authors: Araya Nicolas , Leiva-Soto Martín A. , Bruna Maria V. , Castro-Munoz Almendra , Behrend-Keim Beatriz , Moraga-Espinoza Daniel , Bahamondez-Canas Tania F.
Published: November 2022

Buddleja globosa Hope (BG) extracts are traditionally used to treat skin and gastric ulcers due to their healing properties. Non-aqueous solvents such as ethanol and DMSO are usually used to extract naturally occurring compounds. However, the cytotoxicity of these solvents and the low water solubility of the extracted compounds can hinder their biomedical applications. To overcome the limited solubility of the BG extracts, we aimed to enhance the solubility by processing a standardized hydroalcoholic extract (BG-126) through spray drying (SD), with and without two solubility enhancers. Spray-dried BG (BG-SD) extracts and spray-dried BG extracts plus polyvinylpyrrolidone (BG-SD PVP) and Soluplus® (BG-SD SP) were developed starting from BG-126 (containing 53% ethanol). These four formulations were characterized by total phenolic content, water solubility at 25°C and 37°C, and antimicrobial properties against Pseudomonas aeruginosa. All the SD formulations presented a solubility that allowed them to reach maximum concentrations of 1,024 μg/ml catechin for BG-SD and 2,048 μg/ml catechin for BG-SD PVP and BG-SD SP for antimicrobial testing. BG-SD showed the highest antimicrobial potency with a minimum inhibitory concentration (MIC) of 512 μg/ml catechin, followed by BG-126 with a MIC of 1,024 μg/ml catechin and SP. BG-126 was also shown to inhibit biofilm formation, as well as the excipients PVP and SP. The spray-dried BG (BG-SD) extract represents a promising natural active component with enhanced antimicrobial properties against P. aeruginosa for further research and the development of novel phytopharmaceuticals.
A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach
Authors: Collins Morgan N. , Mesce Karen A.
Published: November 2022

This review article highlights the historical developments and current state of knowledge of an important neuromodulation technology: low-intensity focused ultrasound. Because compelling studies have shown that focused ultrasound can modulate neuronal activity non-invasively, especially in deep brain structures with high spatial specificity, there has been a renewed interest in attempting to understand the specific bioeffects of focused ultrasound at the cellular level. Such information is needed to facilitate the safe and effective use of focused ultrasound to treat a number of brain and nervous system disorders in humans. Unfortunately, to date, there appears to be no singular biological mechanism to account for the actions of focused ultrasound, and it is becoming increasingly clear that different types of nerve cells will respond to focused ultrasound differentially based on the complement of their ion channels, other membrane biophysical properties, and arrangement of synaptic connections. Furthermore, neurons are apparently not equally susceptible to the mechanical, thermal and cavitation-related consequences of focused ultrasound application—to complicate matters further, many studies often use distinctly different focused ultrasound stimulus parameters to achieve a reliable response in neural activity. In this review, we consider the benefits of studying more experimentally tractable invertebrate preparations, with an emphasis on the medicinal leech, where neurons can be studied as unique individual cells and be synaptically isolated from the indirect effects of focused ultrasound stimulation on mechanosensitive afferents. In the leech, we have concluded that heat is the primary effector of focused ultrasound neuromodulation, especially on motoneurons in which we observed a focused ultrasound-mediated blockade of action potentials. We discuss that the mechanical bioeffects of focused ultrasound, which are frequently described in the literature, are less reliably achieved as compared to thermal ones, and that observations ascribed to mechanical responses may be confounded by activation of synaptically-coupled sensory structures or artifacts associated with electrode resonance. Ultimately, both the mechanical and thermal components of focused ultrasound have significant potential to contribute to the sculpting of specific neural outcomes. Because focused ultrasound can generate significant modulation at a temperature <5°C, which is believed to be safe for moderate durations, we support the idea that focused ultrasound should be considered as a thermal neuromodulation technology for clinical use, especially targeting neural pathways in the peripheral nervous system.
Bacteriocyte plasticity in pea aphids facing amino acid stress or starvation during development
Authors: Ribeiro Lopes Mélanie , Gaget Karen , Renoz François , Duport Gabrielle , Balmand Séverine , Charles Hubert , Callaerts Patrick , Calevro Federica
Published: November 2022

An important contributing factor to the evolutionary success of insects is nutritional association with microbial symbionts, which provide the host insects with nutrients lacking in their unbalanced diets. These symbionts are often compartmentalized in specialized cells of the host, the bacteriocytes. Even though bacteriocytes were first described more than a century ago, few studies have explored their dynamics throughout the insect life cycle and in response to environmental stressors. Here, we use the Buchnera aphidicola/pea aphid symbiotic system to study how bacteriocytes are regulated in response to nutritional stress throughout aphid development. Using artificial diets, we analyzed the effects of depletion or excess of phenylalanine or leucine, two amino acids essential for aphid growth and whose biosynthetic pathways are shared between the host and the symbiont. Bacteriocytes responded dynamically to those treatments, while other tissues showed no obvious morphological change. Amino acid depletion resulted in an increase in bacteriocyte numbers, with the extent of the increase depending on the amino acid, while excess either caused a decrease (for leucine) or an increase (for phenylalanine). Only a limited impact on survival and fecundity was observed, suggesting that the adjustment in bacteriocyte (and symbiont) numbers is sufficient to withstand these nutritional challenges. We also studied the impact of more extreme conditions by exposing aphids to a 24 h starvation period at the beginning of nymphal development. This led to a dramatic drop in aphid survival and fecundity and a significant developmental delay. Again, bacteriocytes responded dynamically, with a considerable decrease in number and size, correlated with a decrease in the number of symbionts, which were prematurely degraded by the lysosomal system. This study shows how bacteriocyte dynamics is integrated in the physiology of insects and highlights the high plasticity of these cells.
Herbicide resistance in grass weeds: Epigenetic regulation matters too
Authors: Sen Madhab Kumar , Hamouzová Katerina , Košnarová Pavlína , Roy Amit , Soukup Josef
Published: November 2022

Although herbicides have been successfully used for controlling weeds, their continuous use has developed in the evolution of resistance to all major herbicide modes of action worldwide. Reports suggest that the members of Poaceae family are more prone to developing herbicide resistance than other families. In plants, epigenetic mechanisms play critical roles by increasing their stress-adaptive potential in a rapidly changing environment. Epigenetic mechanisms involve alteration of the expression of genetic elements, but without any changes in the DNA sequence. Although the possible roles of epigenetic mechanisms in contributing to survival and fitness under various stresses are well documented in model plants and crops, their contribution to herbicide resistance in weeds is still in its infancy. A few studies with herbicides have shown differential expression of DNA methyltransferases, histone methyltransferases and DNA demethylases in response to the herbicides; however, no further studies were conducted. In the case of herbicide stress, exploring how these epigenetic processes affect the gene expression pattern in individual plants subjected to recurrent selection would be exciting. Hence, our mini-review will focus on the potential contributions of epigenetic mechanisms to the adaptive responses of grass-weedy species to herbicide stress. A better understanding of these epigenetic changes will add novel perceptions to our knowledge of herbicide resistance evolution in weeds enabling the development of herbicides with novel targets.
Identification of Brachypodium distachyon B3 genes reveals that BdB3-54 regulates primary root growth
Authors: Guo Jie , Liu Hanxiao , Dai Keli , Yuan Xiangyang , Guo Pingyi , Shi Weiping , Zhou Meixue
Published: November 2022

B3 is a class of plant-specific transcription factors with important roles in plant development and growth. Here, we identified 69 B3 transcription factors in Brachypodium distachyon that were unevenly distributed across all five chromosomes. The ARF, REM, LAV, and RAV subfamilies were grouped based on sequence characteristics and phylogenetic relationships. The phylogenetically related members in the B3 family shared conserved domains and gene structures. Expression profiles showed that B3 genes were widely expressed in different tissues and varied in response to different abiotic stresses. BdB3-54 protein from the REM subfamily was located in the nucleus by subcellular localization and processed transcriptional activation activity. Overexpression of BdB3-54 in Arabidopsis increased primary root length. Our study provides a basis for further research on the functions of BdB3 genes.
Profitability determining factors of banking sector: Panel data analysis of commercial banks in South Asian countries
Authors: Yuan Deli , Gazi Md. Abu Issa , Harymawan Iman , Dhar Bablu Kumar , Hossain Abu Ishaque
Published: November 2022

Aim of the article

The main purpose of this article was to investigate the impact of the determinants of profitability on the commercial banks in Asian countries. An Asian country like Bangladesh and India was selected as the research field. The present study also pursues to examine the impact of specific factors and macroeconomic factors on the profitability in the Bangladeshi and Indian private commercial banking sectors.

Methods applied and analysis tools

The data were retrieved from the Annual Reports of Indian and Bangladeshi private commercial banks covering the period of 2010–2021. As sample, 40 private commercial banks were considered randomly, of which 20 were from India and 20 were from Bangladesh. The panel data research methodology was used as an estimation technique to analyze the data. Also, the ordinary least squares (OLS) regression model was used to scrutinize data. To check whether the models were appropriate, the Breusch–Pagan Lagrange Multiplier (LM) Test was employed. Banks' specific factors and microeconomic factors showed almost the same variations for both Bangladesh's and India's private banks. All models and tests were evaluated using E-views econometric software.

The major findings

The present study finds that the Return on Asset (ROA) from the banks' specific variables, strength of the Bank size (BS), and Debt to Asset Ratio (DAR) are found to be positive and significant. For banks, the Deposit to Asset Ratio (DTAR) and the Loan to Deposit Ratio (LDR) are found to be negative and significant. The Equity to Asset Ratio (EAR) and Debt to Equity Ratio (DER) do not have any positive/negative impact.

Contribution, originality, and implications

As macroeconomic variables, the inflation rate (IR) and the GDP growth rate (GDPGR) are measured and found to be positive and significant for ROA. As macroeconomic variables, the Inflation Rate (IR) and the GDP Growth Rate (GDPGR) are found to be positive and significant in the case of ROA. The concerned authorities responsible for regulating the financial performance of the banking sector can use the results of this study to take various fruitful decisions on bank profitability.
The mechanism of body–mind integration in the formation of destination attachment: A comparison of first-time and repeat tourists
Authors: Dong Yinyin , Qu Ying
Published: November 2022

By constructing a person-body–mind-place framework of destination attachment, this study explores the physical and mental formation mechanism of destination attachment and examines its dynamics between first-time and repeat tourists. The present study found that multisensory impressions can, directly and indirectly, affect destination attachment through emotional and cognitive psychological mediation. There are differences between first-time tourists and repeat tourists in terms of this mediation path. As the frequency of travel increases, the influence of multisensory impressions gradually increases. The formation of destination attachment is dominated by emotion for first-time tourists, whereas it is dominated by cognition for repeat tourists. Based on these findings, theoretical and practical implications are presented.
Thinking culture and critical thinking dispositions of high school students in Turkish Republic of Northern Cyprus
Authors: Çelik İskifoğlu Tubanur , Çerkez Yaǧmur , İskifoğlu Gökhan
Published: November 2022

This study aimed to investigate the critical thinking disposition levels of the 15–18 age group of secondary and high school students in different educational settings in the Turkish Republic of Northern Cyprus (TRNC). Since culture is an inevitable part of thinking, this study becomes significant since there is no study investigating the thinking culture of youngsters in North Cyprus. After eliciting necessary permissions from the Ministry of Education and ethical boards, 1,130 participants in the age range of 15–18, who were selected by stratified random sampling and who voluntarily accepted to contribute to the study, took part as a targeted audience. Data was collected from six independent areas of North Cyprus. A Turkish version of the California Critical Thinking Disposition Inventory (CCTDI) was used as the main data collection tool and the data was collected via the online MS Teams platform. The study found that, first, most of the participants scored significantly below the desired criteria set by the related literature for the specified age group. Second, gender differences were studied, and girls were found to be more inclined to think critically than boys in terms of six facets of critical thinking except for truth-seeking. Third, an interesting result regarding urban-rural area distinction was elicited in favor of rural areas, which was contradicted by the related literature, and this finding is discussed under the cultural realms of Cyprus. The basic premises behind each finding and their causal associations with culture are elaborated in detail in the discussion section.
Examining the influencing factors and the functioning mechanism of online learning supporting learners’ empowerment
Authors: Pan Xiaoquan
Published: November 2022

The construction of an effective technology-based environment to promote learning and enable online learning to truly empower learners has become an increasingly important issue of concern. To some extent, an in-depth analysis of the key influencing factors and their functioning mechanism of online learning supporting learners’ empowerment may pave a new way for the understanding of this issue. In view of this, this study, grounded on the reciprocal determinism theory, explored the influencing paths among environment elements, online behaviors, person factors, and learners’ empowerment by using structural equation modeling (SEM) approach, and examined the structure effect relationships among these dimensions. A total of 396 Chinese university students reported on their perceptions of environment elements, online behaviors, person factors, and learners’ empowerment through the questionnaire survey. The results showed that there was a strong correlation between the three dimensions of the reciprocal determinism theory, and the three dimensions all exerted a positive effect on learners’ empowerment. Among them, the item parameter estimates revealed that online environment, online interaction, and online cooperation were significant in explaining the influence of environment elements and online behaviors on learners’ empowerment. Based on the empirical results, this study provided some implications and suggestions for the rationality of the structure devising of online learning environment, the effectiveness of online teacher-student interaction, and the development of students’ learning autonomy in technology-based learning. Thus, this study helped understand the specific contribution of external and internal factors to learners’ empowerment of using technology for online learning and would inform the construction of the optimized online learning environments and teacher-student relationships to enhance students’ sense of online presence and learning initiative.
Gender performances on social media: A comparative study of three top key opinion leaders in China
Authors: Liu Ming , Zhao Ruinan , Feng Jieyun
Published: November 2022

This study gives a critical examination of the performances of three top key opinion leaders (KOLs) on social media in China to explore whether gender serves as an important social factor in their interaction with their followers. A critical analysis of their Weibo posts has revealed that they construct different gender identities through their preferential choices of personality traits, speech acts, and addressing terms. This can be explained in terms of their target consumers and the products they promote. It concludes that although gender can serve as an important factor in top KOLs’ performances on social media, it can be appropriated and exploited in varied ways to serve different communicative purposes.
Curbing boredom in online teaching: Effects of an autonomy-oriented intervention with EAP students
Authors: Rezaee Abbas Ali , Seyri Haniye
Published: November 2022

Despite the growing body of research on boredom and its causes in face-to-face classes, little is known about how pedagogical interventions can mitigate this negative emotion. The purpose of this study was to examine boredom experienced by EAP students in online classes and investigate the effects of an autonomy-oriented intervention program on students’ boredom. The boredom scale was administered to 84 students before and after the autonomy-oriented intervention. By designing and implementing autonomy-oriented intervention based on the autonomy enhancement model, positive results were obtained with reduced levels of boredom. The results revealed that the intervention was effective and boredom was reduced to a noticeable extent. In addition, the qualitative results contributed to our understanding of the learners’ experiences throughout the intervention. We conclude the study with implications for EAP instructors to employ different pedagogical interventions to mitigate negative emotions in online EAP classes.
Research on the influence of college students’ participation in sports activities on their sense of inferiority based on self-esteem and general self-efficacy
Authors: Liu Chu
Published: November 2022

College students need to face various problems and conflicts, and are prone to many negative emotions, such as depression, low self-esteem, social anxiety, low sense of belonging, lack of self-identity, and so on. The generation of these bad emotions will bring unexpected negative effects to college students. Taking Chinese college students as the research object, this study analyzes the influence of sports participation on inferiority. Furthermore, we explored whether self-esteem and general self-efficacy mediated the relationship between physical activity and inferiority. In this study, 115 students were selected to conduct the experiment for 12 weeks. After reliability testing, the collected data were analyzed by multivariate analysis of variance to verify the research model. The results show that sports has a significant positive correlation with the reduction of college students’ inferiority complex. What is important in this model is that self-esteem and general self-efficacy are enhanced during physical activity and decreased during inferiority complex. In addition, this study created three sports situations: competition group, entertainment group and control group. The comparison results show that competitive sports situation is better than leisure sports situation in terms of the influence on college students’ inferiority complex. Through the theoretical and empirical research on college students’ inferiority complex, it is concluded that sports is an effective means to reduce college students’ inferiority complex.
Elective home education of children with neurodevelopmental conditions before and after the COVID-19 pandemic started
Authors: Paulauskaite Laura , Timmerman Amanda , Kouroupa Athanasia , Allard Amanda , Gray Kylie M. , Hastings Richard P. , Heyne David , Melvin Glenn A. , Tonge Bruce , Totsika Vasiliki
Published: November 2022

COVID-19 brought disruptions to children’s education and mental health, and accelerated school de-registration rates. We investigated Elective Home Education (EHE) in families of children with a neurodevelopmental condition. A total of 158 parents of 5–15 year-old children with neurodevelopmental conditions (80% autistic) provided information on reasons for de-registration, their experience of EHE, and children’s mental health. Few differences were found between children participating in EHE before and after the pandemic started. Low satisfaction with school for not meeting children’s additional needs was the main reason for de-registering in both groups. COVID-19 had a more limited role in parents’ decision to de-register. The main advantage of EHE reported in both groups was the provision of personalised education and one-to-one support. Levels of anxiety, internalising and externalising problems were similar between children participating in EHE before and after the pandemic started, and also similar between all children in EHE and school-registered children (N = 1,079).
The structure of dimensions of psychopathology in normative and clinical samples: Applying causal discovery to MMPI-2-RF scales to investigate clustering of psychopathology spectra and p-factors
Authors: Langwerden Robbert J. , Van der Heijden Paul T. , Claassen Tom , Derksen Jan J. L. , Egger Jos I. M.
Published: November 2022

We applied a Bayesian Constraint-based Causal Discovery method (BCCD) to examine the hierarchical structure of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) Restructured Clinical (RC) scales. Two different general psychopathology super spectra (p-factor) scales were extracted from (1) all RC scales and (2) all RC scales except the RCd (Demoralization) scale. These p-factor scales were included in separate models to investigate the structure of dimensions of psychopathology in a normative (n = 3,242) and clinical (n = 2,466) sample, as well as the combined normative/clinical sample (N = 5,708), by applying the BCCD algorithm to obtain a data-driven reconstruction of the internal hierarchical structure of the MMPI-2-RF. Research on the underlying structure of the MMPI-2-RF has clinical relevance as well as conceptual relevance in the context of the HiTOP model. Results demonstrated that the syndromes measured with the RC-scales—in presence of a p-factor—cluster into six spectra: internalizing, disinhibited-externalizing, antagonistic-externalizing, thought disorder, detachment, and somatoform. These results may support a super spectrum construct, as it was necessary for obtaining a bottom-up reconstruction of this six-spectrum structure. We found support for superiority of a broad super spectrum with additional variance over and above demoralization, as it resulted in the clearest structure (i.e., clustering of the RC scales). Furthermore, our results indicate independent support for the bifactor structure model of psychopathology.
Biology of cyclooxygenase-2: An application in depression therapeutics
Authors: He Ying , Han Yuanshan , Liao Xiaolin , Zou Manshu , Wang Yuhong
Published: November 2022

Depressive Disorder is a common mood disorder or affective disorder that is dominated by depressed mood. It is characterized by a high incidence and recurrence. The onset of depression is related to genetic, biological and psychosocial factors. However, the pathogenesis is still unclear. In recent years, there has been an increasing amount of research on the inflammatory hypothesis of depression, in which cyclo-oxygen-ase 2 (COX-2), a pro-inflammatory cytokine, is closely associated with depression. A variety of chemical drugs and natural products have been found to exert therapeutic effects by modulating COX-2 levels. This paper summarizes the relationship between COX-2 and depression in terms of neuroinflammation, intestinal flora, neurotransmitters, HPA axis, mitochondrial dysfunction and hippocampal neuronal damage, which can provide a reference for further preventive control, clinical treatment and scientific research on depression.
Effects of combined training during the COVID-19 pandemic on metabolic health and quality of life in sedentary workers: A randomized controlled study
Authors: Silva Fernanda M. , Duarte-Mendes Pedro , Carvalho Eugénia , Soares Carlos M. , Farinha Carlos , Serrano João , Paulo Rui , Massart Alain , Rodrigues Rafael N. , Teixeira Ana M. , Ferreira José Pedro
Published: November 2022

This study aimed to analyze the effects of a combined training (CT) program performed during the first national lockdown due to the COVID-19 pandemic on body composition, metabolic profile, quality of life and stress in sedentary workers, and examines whether changes in the metabolic profile are associated with changes in health-related outcomes which are modifiable by exercise. We evaluated 31 sedentary workers (48.26 ± 7.89 years old). Participants were randomly assigned to a CT group (i.e., performed 16 weeks of exercise) or to a non-exercise control group. The CT program consisted of 16-week of resistance and aerobic exercise. Body composition, glycemic and lipidic profiles, cardiorespiratory fitness (CRF), health-related quality of life and stress levels were assessed pre- and post-intervention. After the intervention period, the CT group demonstrated significantly lower waist and hip circumference (p < 0.05) values than the control group. The control group significantly increased the fasting glucose and HOMA-IR after 16 weeks follow-up (+4.74 mg/dL, p = 0.029; and +0.41 units, p = 0.010, respectively), whiles no significant changes were observed in the CT group in the same parameters (+3.33 mg/dL, p = 0.176; and +0.04 units, p = 0.628, respectively). No changes were observed in the lipid profile for either group (p > 0.05). A significant positive relationship was detected between the change in BMI with the changes in insulin and HOMA-IR (r = 0.643, p = 0.024; and r = 0.605, p = 0.037, respectively). In addition, the changes in CRF were negatively associated with the changes in total cholesterol (r = −0.578, p = 0.049). We observed differences between groups on perceived stress levels and physical, psychological, and environmental domains of quality of life, with the CT group showing better results. Moreover, the CT group improved perceived life satisfaction (+3.17 points, p = 0.038). The findings of the present study suggest that the participants who remained physically active during the first pandemic-related lockdown were able to mitigate the deleterious effects associated with a sedentary lifestyle.
Does green finance and energy policy paradox demonstrate green economic recovery: Role of social capital and public health
Authors: Xu Li , Xu Chao
Published: November 2022

Green economy development has become a mainstream value orientation in social and global economic development to protect and improve the ecological environment. Multiple stakeholders are needed to address complex issues, such as climate change and its impact on the ecological environment and public health. This study investigates the impact of energy policy and green finance on green economic recovery via the controlling role of social capital and public health. An entropy approach was used to measure the green economic index in addition to an econometric approximation for interpreting the longitudinal dataset for the scenarios for E7 countries between 2010 and 2020. The findings show that the development of green finance significantly improves green productivity. Higher levels of economic and social conditions, a lower level of public involvement in environmental protection, and a higher level of pollution amplify this positive effect. On the other hand, energy policy can enhance the impact of green finance development. The findings suggest that the empirical findings benefit green finance planning and energy policy.
The magnitude of oral rehydration salt utilization in diarrhea hot spot regions of Ethiopia and its associated factors among under-five children: A multilevel analysis based on Bayesian approach
Authors: Negesse Yilkal , Fetene Abebe Gossa , Addisu Abebaw , Setegn Alie Melsew , Alemayehu Dereje
Published: November 2022

Background

Diarrhea leads the children to severe dehydration or death as a result of the loss of water and electrolytes (namely, potassium, chloride, sodium, and bicarbonate). To compensate for the losses, ORS is given to children who experienced diarrhea.

Objective

To estimate the magnitude of ORS utilization in diarrhea hotspot regions of Ethiopia and to assess its associated factors among under-five children.

Methods

To conduct this study, we used the 2016 Ethiopian demographic and health survey data. A total of 1,079 weighted sample children were selected. Each sample was selected randomly. Then, to identify factors associated with ORS utilization in diarrhea hotspot regions of Ethiopia, a multilevel analysis based on the Bayesian approach was applied. Finally, the credible interval of AOR that does not include 1 was considered statistically significant.

Results

The magnitude of ORS utilization for children in diarrhea hotspot regions of Ethiopia was 28%. Being urban resident (AOR = 1.92; 95% CrI: 1.13–3.3), woman household head (AOR = 2.11; 95% CrI: 1.3–3.9), having higher educational level (AOR = 1.52; 95% CrI: 1.04–2.22), member of health insurance (AOR = 1.73; 95% CrI: 1.14–2.43), and being exposed for media (AOR = 1.43; 95% CrI: 1.18–2.5) increases ORS utilization for diarrhea management.

Conclusion

Residence, educational level, health insurance, and media exposure were the factors of ORS utilization. So, to increase the practice of ORS utilization for diarrhea management in Ethiopia, the Ministry of Health and the Government of Ethiopia should consider those factors when they design diarrhea prevention and control strategies.
H is for hypersexual: Sexuality in youths with ADHD
Authors: Hale Elijah W. , Murphy Molly O. , Thompson Katherine P.
Published: November 2022

Background

Recent research into the association between ADHD and hypersexuality has been extremely skewed toward male patients and contribute to stigma against individuals engaging in same sex sexual behaviors. We sought to expand research on this important relationship and to address these shortcomings.

Methods

Using data from the TriNetX database, we created two patient cohorts of patients 21 years or younger, separated by presence or absence of ADHD diagnosis. We analyzed disorders of sexual behavior, comorbid psychiatric illness, and medication type. Those with ADHD were subdivided into same-sex high risk sexual behavior (HRSB) and opposite-sex HRSB. The ADHD group was analyzed based on the presence or absence of any disorder of sexuality. The outcomes measured were disorders of sexual behavior, comorbid psychiatric illness, and medication type.

Results

In a study of 1,355,184 analyzed patient records, patients ADHD were more likely to have all measured outcomes. Orientation of HRSB did not impact for disorders of sexual behavior, but individuals with same-sex HRSB were at higher risk for comorbid psychiatric illness. Those with hypersexuality and ADHD were a higher risk for psychiatric illnesses.

Conclusion

Our study is the largest to date examining associations between hypersexual behaviors and ADHD. Increased awareness of this association may aid in addressing some problematic behaviors before they become detrimental to the individuals with ADHD or others within their lives.
Soft robotics for infrastructure protection
Authors: Milana Edoardo
Published: November 2022

The paradigm change introduced by soft robotics is going to dramatically push forward the abilities of autonomous systems in the next future, enabling their applications in extremely challenging scenarios. The ability of soft robots to safely interact and adapt to the surroundings is key to operate in unstructured environments, where the autonomous agent has little or no knowledge about the world around it. A similar context occurs when critical infrastructures face threats or disruptions, for examples due to natural disasters or external attacks (physical or cyber). In this case, autonomous systems may be employed to respond to such emergencies and have to be able to deal with unforeseen physical conditions and uncertainties, where the mechanical interaction with the environment is not only inevitable but also desirable to successfully perform their tasks. In this perspective, I discuss applications of soft robots for the protection of infrastructures, including recent advances in pipelines inspection, rubble search and rescue, and soft aerial manipulation, and promising perspectives on operations in radioactive environments, underwater monitoring and space exploration.
Recent advances in photoacoustic blind source spectral unmixing approaches and the enhanced detection of endogenous tissue chromophores
Authors: Grasso Valeria , Hassan Hafiz Wajahat , Mirtaheri Peyman , Willumeit-Rӧmer Regine , Jose Jithin
Published: November 2022

Recently, the development of learning-based algorithms has shown a crucial role to extract features of vital importance from multi-spectral photoacoustic imaging. In particular, advances in spectral photoacoustic unmixing algorithms can identify tissue biomarkers without a priori information. This has the potential to enhance the diagnosis and treatment of a large number of diseases. Here, we investigated the latest progress within spectral photoacoustic unmixing approaches. We evaluated the sensitivity of different unsupervised Blind Source Separation (BSS) techniques such as Principal Component Analysis (PCA), Independent Component Analysis (ICA), and Non-negative Matrix Factorization (NNMF) to distinguish absorbers from spectral photoacoustic imaging. Besides, the performance of a recently developed superpixel photoacoustic unmixing (SPAX) framework has been also examined in detail. Near-infrared spectroscopy (NIRS) has been used to validate the performance of the different unmixing algorithms. Although the NNMF has shown superior unmixing performance than PCA and ICA in terms of correlation and processing time, this is still prone to unmixing misinterpretation due to spectral coloring artifact. Thus, the SPAX framework, which also compensates for the spectral coloring effect, has shown improved sensitivity and specificity of the unmixed components. In addition, the SPAX also reveals the most and less prominent tissue components from sPAI at a volumetric scale in a data-driven way. Phantom experimental measurements and in vivo studies have been conducted to benchmark the performance of the BSS algorithms and the SPAX framework.