bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Intrauterine Perfusion of HCG-activated Autologous Human Peripheral Blood Mononuclear Cells on Pregnancy Outcomes in Frozen/thawed Embryo Transfer Cycles of Patients with Different BMIs: A Retrospective Study
Authors: Yang Zhe , Zhao Jing , Zhang Qixuan , Ou Xiangyang , Zhang Mengying , Zhang Yu , Wu Gengxiang
Published: July 2024

Background: In recent years, human peripheral blood mononuclear cells (PBMCs) intrauterine perfusion therapy has been widely used prior to embryo transfer for in vitro fertilization (IVF) to improve implantation rates and pregnancy outcomes in patients. However, there are fewer studies on which groups of people are better able to change pregnancy outcomes with PBMCs. In the present study, we discussed the impact of intrauterine perfusion of PBMCs before thawed embryo transfer (FET) on pregnancy outcomes in patients with different BMIs and ages.
Method: This study retrospectively included 563 patients who received PBMCs uterine perfusion therapy at Reproductive Medical Centre, Renmin Hospital of Wuhan University from 2019 to 2021. Grouped according to different BMI and age, analyze whether these factors influence clinical outcomes in patients receiving PBMCs uterine perfusion.
Result: The results showed that the clinical pregnancy and miscarriage rates were significantly higher in the high BMI group than in the normal BMI group (56.52% versus 44.09%, P=0.041). However, the higher rate of miscarriage in the high BMI group (13.04% versus 5.73%, P=0.037) made the difference in live birth rates not particularly significant (32.61% vs. 31.90%, P=?). This situation was significant in the young patients (age≤30ys), for patients who were advanced reproductive age, it was difficult to improve the clinical pregnancy rate by intrauterine administration of PBMCs.
Conclusion: Intrauterine perfusion of autologous PBMCs prior to transfer in patients undergoing FET modifies clinical pregnancy rates in patients with high BMI. This change is more pronounced in younger patients.
Impact of Regional Comprehensive Cardiovascular Disease Centers on Mortality in Korea
Authors: Jang Ye Seul , Kim Soo Young , Park Eun-Cheol
Published: July 2024

Cardiovascular disease (CVD) remains an important global contributor to mortality and morbidity, with South Korea experiencing higher fatality rates from acute CVD despite excellent hospital care. We investigated regional CVD centers in Korea’s impact on CVD-related mortality rates. This population-based cohort study obtained data from the 2002–2019 Korean National Health Insurance Service–National Sample Cohort. Eleven of the 15 regional CVD centers were included in the study. For the 2 years pre- and post-establishment of the regional CVD centers, 15,687 patients’ data were included in the study. The inclusion criteria included (1) having consulted at an emergency room (ER) with the principal diagnosis of acute CVD, including ischemic and hypertensive CVD, and (2) residing in the area where the regional CVD center was established during the study cohort period. Patients not meeting these criteria were excluded. The dependent variable, CVD-related mortality, included mortalities occurring within 30, 60, and 90 days of the first consultation at the ER. To analyze the time trend and its change in outcomes, an interrupted time-series analysis with segmented regression was performed. There were 8,009 and 7,678 patients in the pre- and post-intervention cohorts, respectively. The probability of death within 30 days after an ER (or regional CVD center) visit among patients with acute heart disease decreased following the designation of the regional CVD center in that area (estimate, 0.9570; 95% confidence interval, 0.9213–0.9942). The designation of regional CVD centers, as part of the government health policy, reduces the acute CVD-related 30-day mortality in patients who have consulted at the ER.
Altered functional connectivity within and between resting-state networks in ulcerative colitis
Authors: Ren Yanjun , Xue Kaizhong , Xu Huijuan , Hao Lijie , Zhao Quchuan , Chi Tianyu , Yang Hongwei , Zhao Xiaojing , Tian Defeng , Zhai Huihong , Lu Jie
Published: July 2024

Background
Patients with ulcerative colitis (UC) commonly present with affective disorders such as depression and anxiety, especially during the active phase of the disease. However, the possible neurological mechanisms of these symptoms remain unclear. The aim of this study was to investigate the alteration of functional connectivity (FC) within each resting-state network (RSN) and between RSNs in ulcerative colitis patients.
Methods
Twelve meaningful RSNs were identified from 22 ulcerative colitis patients and 23 healthy controls using independent component analysis (ICA) of functional magnetic resonance imaging data. Correlation analyses were performed between clinical indices, neuropsychological assessments and neuroimaging data.Results: Compared to healthy controls, UC patients showed increased intranetwork FC, mainly located in the right temporal pole, orbitofrontal cortex, and left superior temporal and Rolandic opercular cortices within the auditory network. In addition, UC patients showed increased connectivity between the dorsal attention and the left frontoparietal network, as well as between the anterior default mode network and the posterior default mode network. No significant correlations were found between altered brain regions and psychological scales in patients with UC.
Conclusions
These findings indicate that patients with UC may experience alterations at the level of the functional network. These alterations may impact not only the intranetwork FC within RSNs, but also the internetwork FC between these RSNs.
Cellulose Nanofiber Reinforced Curcumin-Infused Calcium Phosphate Silicate Cement: Material Characterization and Biocompatibility Assessment for Bone Cancer Defect Repair
Authors: Lu Guoxiu , Meng Lisha , Zhou Jingqiu , Wu Tao , Gong Tianxing , Wu Qiong
Published: July 2024

This study introduces a pioneering approach in bone tissue engineering for addressing defects caused by bone cancer, utilizing a novel injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC). The research focuses on evaluating the dual functionality of CPSC-Cur: promoting bone regeneration and exerting cytotoxic effects on osteosarcoma cells. The material's physicochemical properties, biocompatibility with osteoblasts, and cytotoxicity towards osteosarcoma cells were rigorously analyzed. The findings demonstrate that CPSC-Cur significantly prolongs the setting time, which can be optimized by adding silanized cellulose nanofiber (CNF-SH) to achieve a balance between workability and mechanical strength. Biological assessments reveal a pronounced cytotoxic effect on osteosarcoma cells while maintaining minimal toxicity towards pre-osteoblasts, highlighting CPSC-Cur's potential as a promising material for repairing bone defects following cancer removal. This study lays the groundwork for future investigations into CPSC-Cur's in vivo efficacy and its role in the clinical treatment of bone cancer-related defects.
Selecting hazard-consistent ground motions for seismic risk analysis: an equivalent earthquake-based methodology
Authors: Li Bo
Published: July 2024

Seismic risk analysis has received significant attention from both academia and industry in recent years. When conducting seismic risk analyses, selecting hazard-consistent ground motions is crucial. Traditional methods for selecting hazard-consistent ground motions often have limitations, addressing only a few periods and using discrete intensity levels, which can lead to inaccurate risk estimates. This study introduces a novel methodology that overcomes these limitations by using equivalent earthquakes derived from special seismic hazard disaggregation. This approach generates a scenario earthquake set to simulate target response spectra consistent with the seismic hazards of a target site through importance sampling. A selection scheme is also proposed to identify hazard-consistent ground motions from a database. Furthermore, a new method for performing probabilistic seismic demand analysis is presented. A numerical example demonstrates that the selected ground motions maintain strong consistency with the site's seismic hazard curves across a wide range of periods. Unlike traditional methods, this approach does not depend on the fundamental period of specific buildings, making the selected ground motions applicable for accurate seismic risk analysis of multiple structures at the same site.
The energy dissipation process and dilation evolution of the rock subjected to incremental cyclic loading and unloading
Authors: Wang Bin , Zhu Jiebing , Xu Dongdong , Zhu Yujie
Published: July 2024

Rock mass around underground engineering is sometimes subjected to varying degrees of cyclic load, such as geological tectonic movements, seismic events, excavation, and support of underground caves, which induces some certain deterioration for rock mass strength due to energy dissipation and cumulative micro fractures. Some key scientific questions include the mechanism of energy dissipation and the law of strength parameters' evolution of rock subjected to cyclic increasing loading. In order to clarify the relations between rock energy dissipation and the dilation evolution during the process of failure, an incremental cyclic loading mode is proposed and adopted in uniaxial and triaxial tests. First, the dilation test method and procedure are proposed in this article to improve the test success rate. Granite gneiss specimens sampled from the Southern Xinjiang region were tested to obtain the mineral composition's fundamental mechanical parameters. The incremental cyclic loading uniaxial and triaxial tests are carried out under confining pressure from 0 MPa to 50 MPa during pre-peaking and post-peaking strength periods. From the viewpoint of energy dissipation, the damage variable is defined, and its relationships with the energy dissipation parameters and principal strain(residual strain and residual shear strain) are deeply analyzed during cyclic loading. Moreover, the confining pressure effect on the energy parameters and variables was studied as well. For each cyclic loading and unloading, the relationship between residual volumetric strains versus residual principal strains was acquired from the curves, which provides the fundamental data for further dilation property research. According to the evolution law of damage variable versus plastic shear strain curves, the relationships between energy dissipation ratio and shear dilation angle are constructed. In summary, the research reveals that the damage evolution process of rock is based on the energy dissipation mechanism, and these relationships with its dilation to failure show important significance, which sets up a bridge between the energy mechanism and dilation during the failure process.
Analysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage
Authors: Luo Xinqun , Song Keming , Zhuo Lingyun , Lin Fuxin , Gao Zhuyu , He Qiu , Zheng Yan , Lian Kunbin , Shangguan Huangcheng , Lin Yuanxiang , Kang Dezhi , Fang Wenhua
Published: July 2024

The aim of this study was to delve into the relevant factors affecting hematoma evacuation (HE) rates during the treatment of sICH with stereotactic aspiration combined with catheter drainage. We pooled individual data from our prospective ICH databas, encompassing patients who underwent stereotactic aspiration and catheter drainage between July 2019 and July 2023. The primary outcome was HE rates prior to extubation, the secondary outcome was HE rates within 24 hours postoperatively. Logistic regression was employed to assess relevant clinical and radiological characteristics to establish a predictive model for achieving HE rates ≥ 70%. The model was validated by the ROC curve. Of the 894 patients with sICH enrolled in our database, 106 were eligible for this analysis. Factors affecting HE on the initial postoperative day were determined as preoperative hematoma volume (OR, 0.913; 95% CI, 0.836-0.997; P=0.042), blend sign (OR, 9.457; 95% CI, 0.999-89.508; P=0.050), and the catheter position score (OR, 5.551; 95% CI, 1.231-25.019; P=0.026). The positive blend sign (OR, 4.120; 95% CI, 1.344-12.630; P=0.013), absence of irregular hematoma morphology (OR, 0.291; 95% CI, 0.095-0.893; P=0.031), and hematoma edge not linked to the ventricle (OR, 0.185; 95% CI, 0.036-0.950; P=0.043) emerged as independent predictors for achieving HE rates ≥ 70% prior to extubation. Then, we developed two predictive models: one for early HE rates≥ 70%with a score from 0 to 7, and another for prior to extubation, scoring from 0 to 3. The ROC curve revealed AUC values of 0.871 and 0.753 for each model, respectively, and cutoff values of 5.5 and 1.5, accordingly. The predictive model of HE rates ≥ 70% within 24 hours postoperatively and prior to extuation has demonstrated remarkable predictive capability, holds the potential to assist clinicians in optimizing surgical efficiency.
Trial registration
ClinicalTrials.gov Identifier NCT03862729.
Low-Cost Male Urogenital Simulator for Penile Implant Surgery Training:A 3D Printing Approach
Authors: Wang Zixi , Saija Carlo , Raison Nicholas , Aydin Abdullatif , Xu Zhouyang , Zuo Katie , Rhode Kawal , Pontiki Antonia
Published: July 2024

Background
Penile implant surgery is the standard surgical treatment for end-stage erectile dysfunction. However, the growing complexity of modern high-tech penile prostheses has increased the demand for more practical training opportunities. The most advanced contemporary training methods involve simulation training using cadavers, with costs exceeding $5,000 per cadaver, inclusive of biohazard fees. This study introduces an innovative and cost-efficient male urogenital simulator designed to enhance penile implant surgery training.
Methods
Utilizing image segmentation of patient pre-operative computed tomography (CT) scans, combined with three-dimensional (3D) printing and silicone molding techniques, we developed a high-fidelity simulator replicating the anatomical structures of the male urogenital system. The simulator incorporates an innovative double-layer structural design encompassing the corpus spongiosum and glans, corpora cavernosa, testes, epididymides, and pelvic bones. Additionally, it utilizes a two-stage skin manufacturing process tailored for different skin regions. The simulator was produced at a low material cost of £10, with an average production time of 3 hours. To evaluate its training efficacy, we conducted a penile implant surgery training session involving 15 urology trainees and surgeons ranging from specialty training levels ST3 to ST6. The session began with a demonstration of penile implant surgery and error detection. Trainees, averaging three per simulator, practiced corporotomy, dilation, measurement, penile prosthesis, and scrotal pump placement under expert guidance. Participants' feedback was collected using a Likert scale questionnaire, assessing learning, satisfaction, and anatomical accuracy.
Results
Quantitative analysis of the questionnaire responses indicated highly positive feedback from the participants. Satisfaction rates surpassed 96% in learning effectiveness, over 89% in overall satisfaction, and 86% in anatomical accuracy demonstration. The simulator was favourably reviewed by both urology trainees and experienced surgeons, highlighting its utility as a practical training tool. Its low production cost and high precision make it a viable alternative to current training models.
Conclusions
The development of this cost-efficient, anatomically accurate urogenital simulator through advanced imaging and additive manufacturing techniques represents a significant advancement in penile implant surgical training. This state-of-the-art simulator not only provides a realistic and practical training experience but also underscores the potential for 3D printing technologies to revolutionize medical education and training.
Strategic Safeguarding: A Game Theoretic Approach for Analyzing Attacker-Defender Behavior in DNN Backdoors
Authors: Kallas Kassem , Roux Quentin Le , Hamidouche Wassim , Furon Teddy
Published: July 2024

Deep neural networks (DNNs) are fundamental to modern applications like face recognition and autonomous driving. However, their security is a significant concern due to various integrity risks, such as backdoor attacks. In these attacks, compromised training data introduce malicious behaviors into the DNN, which can be exploited during inference or deployment. This paper presents a novel game-theoretic approach to model the interactions between an attacker and a defender in the context of a DNN backdoor attack.
The contribution of this approach is multifaceted. First, it models the interaction between the attacker and the defender using a game-theoretic framework. Second, it designs a utility function that captures the objectives of both parties, integrating clean data accuracy and attack success rate. Third, it reduces the game model to a two-player zero-sum game, allowing for the identification of Nash equilibrium points through linear programming and a thorough analysis of equilibrium strategies. Additionally, the framework provides varying levels of flexibility regarding the control afforded to each player, thereby representing a range of real-world scenarios.
Through extensive numerical simulations, the paper demonstrates the validity of the proposed framework and identifies insightful equilibrium points that guide both players in following their optimal strategies under different assumptions. The results indicate that fully using attack or defense capabilities is not always the optimal strategy for either party. Instead, attackers must balance inducing errors and minimizing the information conveyed to the defender, while defenders should focus on minimizing attack risks while preserving benign sample performance. These findings underscore the effectiveness and versatility of the proposed approach, showcasing optimal strategies across different game scenarios and highlighting its potential to enhance DNN security against backdoor attacks.
Synthesis and Characterization of New Organometallic Lanthanides Metal Complex with Promising Photo Physical Activities
Authors: Batouti mervette El , El-Mossalamy E. H. , Desouky J. M. El , Fetouh Howida
Published: July 2024

New Schiff base ligand 4-methoxy salicaldhyde (3-hydrazonobutan-2-one) has been prepared. Molecular structures is characterized by elemental analysis, melting point.1H-NMR spectra (3.5 ppm-10.39ppm) confirmed protons and 13C-NMR confirmed carbons. New optically active metal complexes of Sm(III), Gd(III) and Tb(III) Schiff were synthesized in one pot reaction. Vibrational IR bands confirmed multifunctional groups. Scanning electron microscopy (SEM) micrographs confirmed microstructure of metal complexes. Good optically activity of solid complexes are confirmed from electronic absorption spectra. X-ray diffraction patterns confirmed good crystalline structure of the metal complexes. Large absorption wavelength λmax.280–390 nm and intense phosphorescence bands up to 730 nm of metal complex enabled application in photo dynamic therapy for cancer cells by enhancing cell apoptosis. Metal complexes act by conversion oxygen in tissue into reactive singlet oxygen that destroy cancer cell. Low charge transfer energy: 2.59 eV-2.61 eV and high molar extinction coefficients ε 6×104 M-1cm-1 reflected good optical activity.
M&M3D: Multi-Dataset Training and EfficientNetwork for Multi-view 3D Object Detection
Authors: Zhang Hang
Published: July 2024

The research focuses on the challenge of domain adaptation and visual data transfer in camera-only 3D object detection. Despite numerous advancements in borderline methods, their performance significantly decreases across domains. 'M\&M3D' is introduced as a novel training approach for multi-view 3D object detection utilizing exclusively camera data under the multi-dataset training. 'M\&M3D' leverages 2D multi-view image features, 3D anchor queries and 3D space information as positional information and relies on a modest amount of source data as the visual-language transfer design. 'M\&M3D' exhibits favorable performance on standard metrics of 3D object detection with a smaller network size, distinguishing itself from dataset-specific models that require longer training time and individual fine-tuning on source domain. It might ignite future deployment of models on smaller devices.
Expanding housekeeping gene concepts: The role of retroelements in gene expression stability across tissues
Authors: Park Hyeon-Chun , Choi Haeyoun , Kim Sukil , Choi Jinyong , Oh Jung-Hwan , Rhyu Mun-Gan , Hong Seung-Jin
Published: July 2024

Background
Housekeeping genes (HKGs), essential for cellular differentiation, are traditionally thought to be uniformly expressed. However, recent analyses revealed variable expression of most genes across tissues, challenging this view. Identifying HKGs based on stable expression necessitates precise, repeated experiments. The limited number of transcription factors during differentiation implies that HKGs stabilise phenotypes through compensatory gene regulation.
Methods
We investigated the influence of retroelements, which constitute approximately 40% of the human genome, on gene expression stability based on proximity to transcriptional start sites (TSSs). By mapping CpG islands and retroelements within 10 kb of TSSs, we analysed 56 RNA sequencing datasets.
Results
CpG-island genes near Alu elements exhibited low expression variability, especially when the Alu elements were closer to the TSSs. Conversely, non-CpG island genes near L1 and LTR elements showed high variability, indicating distinct regulatory roles. Despite the constant number of Alu-adjacent CpG-island genes across tissues, their expression was the strongest in embryonic stem cells and declined in most differentiated tissues, except for an increase in the ovary and testis.
Conclusions
Alu elements near CpG islands help stabilise phenotypes through compensatory downregulation of HKGs. These findings support the expansion of the HKG concept to include genes maintaining stable phenotypes during tissue differentiation, aiding in differentiation stage identification.
Optimization of hexavalent chromium removal from aqueous solutions using Eichhornia crassipes-derived adsorbents through a response surface methodology
Authors: Tri Chu Luong , Tung Vo Hoang , Hong Nguyen Thi , Tuan Le , Nguyen Dinh Duc , Nguyen X. Cuong , La D. Duc , Le Duy Khuong
Published: July 2024

Heavy metal contamination, particularly hexavalent chromium (Cr(VI)), in water bodies poses severe environmental and health risks. In recent years, using natural adsorbents for removing heavy metals has gained intensive interest thanks to their eco-friendliness and cost-effectiveness. In this work, lignocellulosic biomass materials were modified and employed as adsorbents to remove Cr(VI) from contaminated water. Adsorbent materials derived from Eichhornia crassipes showed the significance of removing Cr (VI) from the aqueous solution after being treated by H2SO4 acid 1.5% w/v at 45oC for 30 h. After localising the upper and lower limits of each factor, design under the response surface models (RSM) using the Box–Behnken Design (BBD) method was used to optimise enhancement of the removal of Cr(VI). The strategy showcased the ability to construct a second-degree polynomial model that is highly valid (R2˃0.9805) and includes statistically significant interactions (P < 0.05). The findings indicated that the highest capacity for adsorbing Cr(VI) was 41.53 mg/g, which was attained by using 15 g/L of adsorbent, maintaining a pH of 3, starting with a Cr(VI) concentration of 130 mg/L, and allowing a contact duration of 80 minutes.
Mitochondria transfer transiently rescues cerebellar neurodegeneration at early stage by alleviating mitophagy
Authors: Wang Yayun , Li Shu-Jiao , Zheng Qian-Wen , Zheng Jie , Zhang Jin-Bao , Liu Hui , Tie Jing-Jing , Zhang Kun-Long , Wu Feifei , Li Xiaodong , Zhang Shuai , Sun Xin , Yang Yan-Ling
Published: July 2024

Cerebellar ataxia is the main manifestation of cerebellar degenerative diseases, and the mitochondrial function of Purkinje cells (PCs) plays a key role in the disease. And treatments targeting the cerebellum need further research. We constructed a model of cerebellar PCs degeneration, characterized by ataxia, through conditional knockout of Drp1 in PCs (PCKO mice). And we further explored the pathogenesis and possible effective treatment of cerebellar degenerative diseases. Drp1 knockout results in pervasive and progressive apoptosis of PCs, accompanied by severe glial cell activation surrounding them. Mitochondrial dysfunction, as a cause of mitophagy, is a key pathogenic factor of PCs morphological damage and dysfunction. Transfer of liver-derived mitochondria into the cerebellum of PCKO mice at 1 month improved mitochondrial function and reduced mitophagy, resulting in a delay of PCs apoptosis and cerebellar ataxia for 3 weeks. This study demonstrates that mitochondria transfer may be an potential treatment for cerebellar degenerative diseases.
Relationship between peritumoral brain edema and Ki-67 antigen labelling index in intracranial meningiomas
Authors: Mahbub Abdullah Al , Esha Tamanna Ahmed , Rahman Mantaka , Nath Prof. Dr. Haradhan Deb
Published: July 2024

Introduction: The most common benign non-glial cerebral tumor in adults is a meningioma. In roughly 50–78% of instances, peripheral brain edema (PTBE) is a common observation in meningioma, while it may not be present in others. Although the Ki67 proliferation index may be able to predict the recurrence of tumors in meningioma patients, there is a lack of conclusive evidence and relationships.
Objective: To enhance evaluation, correlate the Ki67 index of meningioma patients with peritumoral cerebral edema.
Methods: This cross-sectional study involved 24 patients with meningioma (20 female, 4 male; mean age 39.95 ± 14.54 years). Pre-operative neuroimaging was used to evaluate all patients for the presence of cerebral edema surrounding the lesion using brain MRI and histological confirmation. An immune-histochemical staining known as the Ki-67 index was used to measure proliferative activity. The possibility of a relationship between the levels of the Ki67 index and the existence of PTBE was investigated.
Result: WHO grade I tumors were identified in approximately twenty-three (95.8%) of the patients with PTBE, mean age 39.95 with 14.54 SD and male to female ratio 5:1. Eight patients (33.3%) were classified as GR1patients, one as GR2, and the majority of patients (15/62.5%) as GR0 patients. For G1, the greatest level is represented by the mean value of the Ki-67 Index level, which is 7.00. When compared to gender, tumor location, and meningioma type (p>0.05), the PTBE grading was statistically significant when it came to the Ki-67 indices (p<0.05). Furthermore, the grading of peritumoral edema (PTBE) and the Ki-67 labelling index value exhibited a substantial positive association, as indicated by the spearman correlation test, with a significant p-value <0.05 and a coefficient value of r = 0.647.
Conclusion: Peritumoral brain edema (PTBE)-encircled meningioma had a strong correlation with Ki67 indices.
51 year old patient with Familial Mediterranean fever (FMF), Type 2 Diabetes Mellites (T2DM) and Multiple Sclerosis (MS)- case report
Authors: Tassabehji Omar , Alayoubi Alisar , mansour anas , Arkoub Hussein , Jbeily Rajwa Daowd
Published: July 2024

Familial Mediterranean fever (FMF) is a genetic disorder that follows an autosomal recessive pattern and is characterized by recurrent episodes of febrile peritonitis, synovitis, and pleuritis. Many studies associate FMF with MS1. Multiple Sclerosis is the most common non-traumatic disabling disease affecting young adults.2 The cause of MS remains unclear, since MS is a complex disease, Inflammation, demyelination, and axonal degeneration are the major pathologic mechanisms that cause the clinical manifestations.3 Type 2 Diabetes Mellites( T2DM ) is considered to have the highest prevalence amongst other diseases affecting over 340 million people worldwide4 characterized with resistance to insulin and disrupted function for beta cell istle in the pancreas. Which together result in insufficient supply of insulin5.
our patient is a 51-year-old male, that has FMF and T2DM and recently developed neurological symptoms related to MS, which is a very rare occurrence that urged us to do further testing and imaging which made the diagnosis clear it was MS. All three diseases co existing is the reason we wrote this case report, to shed the light on such abandoned cases for patients who might be diagnosed earlier if got regularly clinical tests.
Evolution of radiology staff perspectives during artificial intelligence (AI) implementation for expedited lung cancer triage
Authors: Togher Daniel , Dean Geraldine , Moon Jo , Mayola Richard , Medina Arman , Repec Jadwiga , Meheux Moesha , Mather Sarah , Storey Mathew , Rickaby Simon , Abubacker Mohamed Ziad , Shelmerdine Susan
Published: July 2024

ObjectivesTo investigate radiology staff perceptions of an AI tool for chest radiography triage, flagging findings suspicious for lung cancer to expedite same day CT chest examination studies.MethodsSurveys were distributed to all radiology staff at three time points: at pre-implementation, one month and also seven months post-implementation of AI. Survey questions captured feedback on AI use and patient impact.ResultsSurvey response rates at the three time periods were 23.1% (45/195), 14.9% (29/195) and 27.2% (53/195) respectively. Most respondents initially anticipated AI to be time saving for the department and patient (50.8%), but this shifted to faster follow-up care for patients after AI implementation (51.7%). From the free text comments, early apprehension about job role changes evolved into frustration regarding technical integration challenges after implmentation. This later transitioned to a more balanced view of recognised patient benefits versus minor ongoing logistical issues by the late post-implementation stage. There was majority disagreement across all survey periods that AI could be considered to be used autonomously (53.3 - 72.5%), yet acceptance grew for personal AI usage if staff were to be patients themselves (from 31.1% pre-implementation to 47.2% post-implementation).ConclusionSuccessful AI integration in radiology demands active staff engagement, addressing concerns to transform initial mixed excitement and resistance into constructive adaptation. Continual feedback is vital for refining AI deployment strategies, ensuring its beneficial and sustainable incorporation into clinical care pathways.
Lehrende im Spannungsfeld zwischen Erwerb und Vermittlung von digitalen Kompetenzen
Authors: Stemmer Janina , Lampe Katherina , Terme Sandra
Published: July 2024

Die fortschreitende Digitalisierung prägt die Bildungswelt und erfordert von Lehrenden spezifische digitale Kompetenzen, die über traditionelle didaktische Kernkompetenzen hinausgehen und diese erweitern. Lehrende sind dazu angehalten digitale Medien zielgerichtet in der Lehre einzusetzen und gleichzeitig die digitalen Kompetenzen der Studierenden zu fördern. In dem Beitrag wird untersucht, wie Lehrende durch den Umgang mit dem Learning Management System (LMS) ILIAS diesen Anforderungen gerecht werden können. Im Rahmen des Verbundprojekts «DigikoS – Digitalbaukasten für kompetenzorientiertes Selbststudium» wurde hierfür eine Toolbox entwickelt, die Lehrende situativ und bedarfsorientiert unterstützen soll. Die zentrale Fragestellung des Artikels bezieht sich auf die Inhalte der Toolbox: Es galt herauszufinden, welche Lernangebote notwendig sind, um die digitalen Kompetenzen von Lehrenden für ihre digital gestützte Lehre sowie im Rahmen der Nutzung des LMS ILIAS zu erweitern. Zusätzlich wird dabei die Förderung der digitalen Kompetenzen sowie der Selbstlernkompetenz Studierender näher betrachtet, da diese wesentlich für ein erfolgreiches Lernen mit digitalen Medien sind. Hierfür erfolgt zunächst eine Vorstellung der Kompetenzanforderungen, welche durch Erfahrungen aus der Lehrpraxis ergänzt werden. Aus diesen Ergebnissen werden abschliessend die Inhalte der Toolbox abgeleitet. Der Beitrag bietet einen Einblick in die komplexe Thematik digitaler Kompetenzen in der Hochschullehre.
ORGANIZATION OF TRANSPLANTATION ASSISTANCE THROUGH TRANSPORTATION OF THE RECIPIENT TO THE REGIONAL EXPLANTATION BASE FOR HEART TRANSPLANTATION
Authors: Kovtun Gavrylo , Shpachuk Anton , Chaikovska Sofia , Sudakevych Serhii , Todurov Borys
Published: July 2024

Introduction. To date, heart transplantation remains the only effective method of treatment for patients with end-stage chronic heart failure. Due to the short time of ischemia of the donor heart and the lack of an alternative to deliver the organ on time over long distances, the strategy in organizing transplantation was changed. The aim of this study was to analyze the effectiveness of transporting the recipient to the donor to reduce the ischemia time of the donor organ during martial law.
Materials and methods. This retrospective study includes all cases of heart transplantation carried out by specialists of the State Institution "Heart Institute of the Ministry of Health of Ukraine" during 2022–2024. Heart transplantations were performed directly in our center and on-site. Outpatient surgery involved heart transplantation in the medical facility where the donor was located or in the nearest hospital.
The results. The study included 55 patients who underwent orthotopic heart transplantation, of which 20.0% were women and 80.0% were men. Depending on the place of heart transplantation, all patients were divided into two groups: the first group (32 patients) – heart transplantation in the State Institution "Heart Institute of the Ministry of Health of Ukraine" and the second group (23 patients) – heart transplantation elsewhere. The duration of donor heart ischemia was not significantly different between the study groups (95.4±15.3 min vs. 90.3±10.8 min, p=0.167), although there was a tendency to decrease in the patients of the second group. Hospital survival was 93.8±4.28% among patients of the first group and 91.3±5.87% among patients of the second group (p=0.408). 12-month survival in the study groups was 87.5±5.84% versus 86.9±7.02% (p=0.375).
Conclusions. The use of recipient-to-donor transportation not only made it possible to reduce the duration of ischemia of the donor heart, but also presented with a similar level of hospital and 12-month survival, which makes it possible to effectively apply this method in wartime conditions when there is no possibility of helicopter transportation.
Eksplorasi Nilai-Nilai Pancasila Dalam Memerangi Bullying di Lingkungan Perguruan Tinggi
Authors: Sahrona Sahrona
Published: July 2024

This study explores the implementation of Pancasila values, specifically justice, tolerance, equitable humanity, mutual cooperation, and wise leadership, in the Pancasila Education course at the higher education level to address bullying cases. The research employs a qualitative method with a phenomenological approach to deeply understand students' comprehension of Pancasila values in this context. The results indicate that the incorporation of these values in the coursework significantly enhances students' understanding, attitudes, and commitment to preventing and addressing bullying on campus. By involving students in learning activities that include discussions, projects, field practices, awareness campaigns, and reflections, character education grounded in Pancasila can serve as a crucial foundation in shaping students with strong social consciousness, preparing them to face future challenges.
 

Penelitian ini mengeksplorasi pelaksanaan nilai-nilai Pancasila, khususnya nilai keadilan, toleransi, kemanusiaan yang adil, gotong royong, dan kepemimpinan bijaksana, dalam mata kuliah Pendidikan Pancasila pada tingkat perguruan tinggi untuk menanggulangi kasus bullying. Penelitian menggunakan metode kualitatif dengan pendekatan fenomenologi untuk mendalami pemahaman mahasiswa terhadap nilai-nilai Pancasila dalam konteks ini. Hasilnya menunjukkan bahwa pelaksanaan nilai-nilai tersebut dalam perkuliahan secara signifikan meningkatkan pemahaman, sikap, dan komitmen mahasiswa dalam mencegah dan mengatasi bullying di lingkungan kampus. Dengan melibatkan mahasiswa dalam kegiatan pembelajaran yang mencakup diskusi, proyek, praktik lapangan, kampanye kesadaran, dan refleksi, pendidikan karakter yang kuat didukung oleh Pancasila dapat menjadi landasan penting dalam membentuk mahasiswa yang memiliki jiwa sosial yang kuat dan siap menghadapi tantangan di masa depan.
İRAN-HİNDİSTAN SAHASINDA HÜKÜM SÜREN BAZI ORTA ÇAĞ TÜRK DEVLETLERİNDE FİLLERİN AYAKLARI ALTINDA EZDİRMEK CEZASI VE UYGULANIŞI HUSUSUNDA BİRTAKIM TESPİTLER
Authors: Tarifci Sinan
Published: July 2024

Hayvanlar âleminde müstesna bir yer işgal eden fillerden pek çok farklı alanda istifade edilmiştir. Savaş, nakliye, avlanma, geçit resmi, gezinti gibi eylemlerde filden yararlanıldığı gibi, hediyeleşmeler ve merasimlerde de fil kullanılmıştır. Filin kullanım alanlarından biri de ölüm cezasının infazıdır. Kahramanlık ve güç kaynağı olan fillerin ayakları altında ezdirmek cezası, dönemin anlayışına göre, hükümdarın cezalandırıcı otoritesini sembolize ediyor, haşmetini ve hayranlık uyandıran etkileyiciliğini artırıyordu; öte yandan da ciddi bir caydırıcı niteliği haizdi. Bu ceza, başlıca askerî ve siyasî mahiyette devlete ve sultanın şahsına karşı işlenen suçlar ile asayişe ilişkin suçlara karşı verilmiştir. Bunun için özel olarak eğitilmiş ve teçhiz edilmiş filler kullanılırdı. Bu çalışmada, İran-Hindistan sahasında teşekkül eden Orta Çağ Türk devletlerinden hususiyetle Gazneliler, Büyük Selçuklular ve Delhi Türk Sultanlığı zamanında tatbik edilen fillerin ayakları altında ezdirmek cezası ve uygulanışı hususunda bazı dönem kronikleri, edebî eserleri, siyasetnameleri ve seyahatnamelerine, bu arada tetkiklere istinaden birtakım tespitlere yer verilecektir.
Removing Excess Iron from Sewage and Natural Waters: Selecting Optimal Sorbent
Authors: Ivanova Ludmila , Timoshchuk Irina , Gorelkina Alena , Mikhaylova Ekaterina , Golubeva Nadezhda , Neverov Evgeniy , Utrobina Tamara
Published: July 2024

Natural waters and wastewaters often contain heavy metals, e.g., iron. Iron ore mining contaminates groundwater with iron up to 30 maximal permissible concentrations (MPC) as this element gets washed out from rock and soil. Adsorption is the most effective and economically feasible method of additional purification of natural and wastewater from iron. Its efficiency depends on the type of adsorbent. The research objective was to select the most efficient sorption material to eliminate water from iron, as well as to establish the adsorption patterns for different sorbents, thus creating sustainable and effective purification.
The study featured carbonaceous sorbent of the SKD-515 grade, mineral sorption materials with aluminosilicate of the AC grade, and silicate-based sorbent of the ODM-2F grade. The porous structure was studied by porometry methods while the surface image was obtained using scanning electron microscopy. Other indicators included equilibrium, kinetics, and dynamics of iron adsorption by various sorbents.
The Freundlich and Langmuir equations made it possible to calculate the key adsorption parameters. The Gibbs energy values were obtained from the Langmuir equation and equaled 11.93–20.66 kJ/mol, which indicated the physical nature of the adsorption process. Under static conditions, the sorbents demonstrated a high adsorption capacity with respect to iron, depending on the structure, and could be arranged as AC > SKD-515 > ODM-2F. In SKD-515, iron adsorption occurred in micropores; in AC and ODM-2F, it took place in mesopores. The kinetics of iron extraction showed that the adsorption process was limited by external mass transfer.
The research provided a new understanding of iron adsorption by materials of various structures. The conclusions were supported by scanning electron microscopy images. Initial concentration, flow velocity, and loading layer height were studied in dynamics, i.e., during continuous operation of the adsorption column. The system proved extremely effective and reached 99.0% Fe3+ extraction under the following conditions: flow rate = 1 L/min, loading column height = 0.15 m, column diameter = 0.05 m, initial concentration = 0.5 mg/L (5 MPC). The column performance was tested at an initial concentration of iron ions of 50 MPC, which simulated the wastewater treatment at industrial enterprises. This comprehensive study of iron adsorption from wastewater proved the efficiency of the mineral sorption materials with aluminosilicate of AC grade.
Design storm parameterisation for urban drainage studies derived from regional rainfall datasets: A case study in the Spanish Mediterranean region
Authors: Balbastre-Soldevila Rosario , Andrés-Doménech Ignacio , García-Bartual Rafael
Published: July 2024

A significant amount of information on regional rainfall characteristics is available nowadays, allowing its use in hydrological applications. This article is motivated by the availability of regional studies regarding maximum daily rainfall and intensity–duration–frequency curves that can be coupled with the design storm concept for urban hydrology studies. This is accomplished through a convenient index describing temporal variability of rainfall. More precisely, a methodology for regionalising the two parameters (i0, φ) of the two-parameter gamma design storm (G2P) is developed herein. A three-step methodology is proposed for obtaining the two parameters (i0, φ) for a given location. The results obtained in a case study show coherence with previous studies concerning maximum rainfall statistics.
Review paper on applications of the HEC-RAS model for flooding, agriculture, and water quality simulation
Authors: Zainal Norsaliha Najwa , Abu Talib Siti Hidayah
Published: July 2024

The Hydrologic Engineering Center (HEC) of the United States Army Corps of Engineers (USACE) has developed the HEC-River Analysis System (RAS) hydraulic channel flow model as part of its portfolio of hydrologic and hydraulic modeling tools. HEC-RAS is a new version with capabilities to model flooding, modeling for agriculture production computations for water quality, and many more related to hydraulic modeling. The analysis components of the HEC-RAS system include one-dimensional steady flow water surface profile computations, one-dimensional and or two-dimensional unsteady flow simulation, one-dimensional and two-dimensional computations of quasi-unsteady or fully unsteady flow movable boundary sediment transport, and one-dimensional water quality analysis. The main objective of this paper is to review the use of HEC-RAS on flooding, agriculture, and water quality. The three primary components of the data input are plan data, geometry data, and flow data. Three of these scenarios applied to HEC-RAS and were proven by previous reviewers.
Assessment of health risk and socio-economic losses associated with nutrition-related non-communicable diseases
Authors: Efimova N.V. ,   East-Siberian Institute of Medical and Ecological Research, 3 microdistrict 12a, Angarsk, 665827, Russian Federation, Bogdanova O.G. ,   East-Siberian Institute of Medical and Ecological Research, 3 microdistrict 12a, Angarsk, 665827, Russian Federation
Published: July 2024

Mortality among the Irkutsk region population was chosen as a research object. The aim of this study was to assess socioeconomic losses and the epidemiological risk caused by nutrition-related non-communicable diseases, including diseases of the circulatory system, among adult working age population in the Irkutsk region. The study was cross-sectional and observational. We analyzed data on mortality, gross regional product and employment provided by the Territorial office of the Federal State Statistic Service in the Irkutsk region over 2011–2020. Social and economic losses caused by early mortality among the population in the Irkutsk region were calculated in accordance with the Methodical Guidelines on using the Potential years of life lost (PYLL) indicator to establish priority health issues of the Russian population at the federal, regional and municipal level. Data were analyzed using Statistica 6.0. The assessment revealed that over 2011–2020 mortality caused by nutrition-related non-communicable diseases on average accounted for 13.85 % (13.64; 14.07) of the overall population mortality. Average annual social losses equaled 154,827.00 (153,098.56; 156,555.44) person-years lost before a person reached the end of working age. Accompanying probable economic losses aggregated over the analyzed period ranged between 9,560.58 and 15,934.29 million rubles. We managed to build acceptable predictive models (R2 > 0.5) on the growth in economic losses due to mortality caused by nutrition-related non-communicable diseases for both sexes and for males living in the Irkutsk region. Our findings highlight the significance of socioeconomic losses caused by nutrition-related non-communicable diseases and give evidence of suboptimal diets being widely spread among the population of the Baikal region.
Multidrug resistance of uropathogens as a risk factor in providing medical care to patients from central Bulgaria
Authors: Alekova S. ,   Trakia University, 11 Armeiska St., Stara Zagora, 6000, Bulgaria, Koycheva R. ,   Trakia University, 11 Armeiska St., Stara Zagora, 6000, Bulgaria
Published: July 2024

The emergence of resistance to multiple antimicrobial agents in uropathogenic bacteria has become a significant public health problem. These microorganisms are the cause of urinary tract infections, which are among the most frequently treated diseases in the outpatient medical care. A cross-sectional study was conducted among 353 outpatients over 18 years of age with positive urine sample culture. It involved measuring the index of multiple antibiotic resistance of uropathogens causing infections among individuals. The research was conducted in the period January – June 2023 at a private clinical laboratory center located in Stara Zagora, Bulgaria. One third of the isolates of E. coli and more than a half of those of Klebsiella pneumoniae had a measured MAR index greater than 0.2, with confirmatory high rates of resistance to aminopenicillins and cephalosporins. Alarmingly high MARI values were measured in all representatives of Enterococcus faecalis, Enterobacter species and Pseudomonas aeruginosa. These strains were also established to have high levels of resistance (varying from 58.3 to 100 %) to some of antimicrobial medicines most commonly prescribed in the outpatient healthcare. Findings of this study emphasize the importance and seriousness of the existing problem with the increasing prevalence of uropathogenic microorganisms with multiple resistance to oral antibiotics. This creates elevated risks of failure to provide effective treatment for patients.