bluuebunny/crossref_metadata_2025 huggingface dataset:
Interference of orthodontic treatment in the human identification process by the palatine rugae
Authors: Spindola Michelline Oliveira Pedrosa , Gatis Michelly Cauás de Queiroz , Sousa Eliane Helena Alvim , Andrade Emanuel Savio de Souza
Published: February 2024

This observational study investigate the interference of fixed orthodontic treatment on the morphology of palatine rugae, and the compromise the process of forensic human identification. Of the 51 cases studied (26 males), aged between 7 and 39 years. The principal morphological changes included a second right rugae in males (50%) and a third left rugae in females (56%); the anterior rugae were more altered in males. The most significant change in architecture was between the ages of 22 and 39, with a 57.1% rate for the third right rugae. No statistically significant difference was observed between morphological rugae patterns and gender, skin color, or age. The prevalence of the bifurcated type for the first right rugae; the straight type for the second right and left rugae and the sinuous type for the third right and left rugae. For the initial rugae, there was a correspondence of 43.1–47.1% for the oval shape before and after treatment, respectively. Concluding that the fixed orthodontic treatment may result in morphological modifications to the palatine rugae.
SM22α deficiency: promoting vascular fibrosis via SRF-SMAD3-mediated activation of Col1a2 transcription following arterial injury
Authors: Shen Jianbin , Ju Donghong , Wu Shichao , Zhao Jiawei , Pham Lucynda , Ponce Alejandro , Yang Maozhou , Li Hui Joyce , Zhang Kezhong , Yang Zhe , Xie Youming , Li Li
Published: February 2024

Vascular fibrosis, characterized by increased Type I collagen expression, significantly contributes to vascular remodeling. Our previous studies show that disrupting the expression of SM22α (aka SM22, Tagln) induces extensive vascular remodeling following arterial injury, involving oxidative stress, inflammation, and chondrogenesis within the vessel wall. This study aims to investigate the molecular mechanisms underlying the transcription of Col1a2, a key fibrotic extracellular matrix marker. We observed upregulation of COL1A2 in the arterial wall of Sm22−/− mice following carotid injury. Bioinformatics and molecular analyses reveal that Col1a2 transcription depends on a CArG box in the promoter, activated synergistically by SRF and SMAD3. Notably, we detected enhanced nuclear translocation of both SRF and SMAD3 in the smooth muscle cells of the injured carotid artery in Sm22−/− mice. These findings demonstrate that SM22 deficiency regulates vascular fibrosis through the interaction of SRF and the SMAD3-mediated canonical TGF-β1 signal pathway, suggesting SM22α as a potential therapeutic target for preventing vascular fibrosis.
A bioinformatics-based analysis of chromatin regulators in atrial fibrillation uncovers potential novel biomarkers and immune infiltration characteristics
Authors: Li Yue , Han Xiao , Wang Fei , Chen Mengxi
Published: February 2024

Objective: To identify potential novel biomarkers and characterize immune infiltration in atrial tissue of patients with atrial fibrillation (AF) through bioinformatics analysis.
Methods: Three AF datasets (GSE31821, GSE41177, and GSE79768) from the Gene Expression Omnibus (GEO) database were integrated to identify differentially expressed genes(DEGs) related to chromatin regulators(CRs). Functional and pathway enrichment analyses were undertaken using GO,DO,and KEGG.10 hub genes from the protein-protein interaction (PPI) network of DEGs were utilized to predict possible drugs and miR-RNA.Furthermore,gene set enrichment analysis (ssGSEA) method was used to analyse immune cells immune infiltration in AF and identifythe most signifcant potential biomarkers.Finally,Diagnostic model was constructed to predict the individual risk of AF.
Results: A total of 77 DEGs related to CRs were identifed in AF patients compared with control group.Six hub DEGs(RBBP4, KAT7,KANSL2, ACTB, TRRAP,and KAT2B) and fourimmune cell subpopulations (tumor-infiltration lymphocyte ,master cells, neutrophils, regulatory T cells) were identifed as the most signifcant potential regulators.Hsa-miR-142-3p,hsa-miR-639,hsa-miR-3681,and hsa-miR-4280 were selected as potential therapeutic targets at post-transcriptional level.Then,we predicted 4 potential small molecule drugs(STOCK1N-28457,diphenylpyraline,hesperetin,dorzolamide )
Conclusion: The DEGs related to CRs and immune cells identifed in our study may be critical in AF development and provide potential predictive markers and therapeutic targets for determining a treatment strategy for AF patients.
Prognostic value of red blood cell distribution width for mortality in patients with sepsis-induced cardiomyopathy: a propensity score-matched cohort study
Authors: Liao Jian , Lu Dingyu , Zhang Lian , Wang Maojuan
Published: February 2024

Background The potential association between red blood cell distribution width (RDW) at admission and prognosis in patients with sepsis-induced cardiomyopathy(SIC) remains uncertain. The purpose of this study was to explore the prognostic value of RDW on mortality in patients with SIC.
Methods Data for this retrospective study were obtained from the MIMIC IV2.2 database.
We used propensity score matching (PSM) and Cox proportional hazards regression analysis to evaluate the main risk factors associated with mortality in SIC patients. This analysis was utilized to develop a predictive nomogram. To assess the predictive accuracy and clinical usefulness of the model, we employed the concordance index (C-index) and decision curve analysis. To define the high- and low-RDW groups among patients with SIC, we determined the optimal cut-off value by maximizing the Youden index.
Results According to the screening criteria, we identified a cohort of 1051 patients diagnosed with SIC. When comparing the high-RDW group to the low-RDW group, it was found that the high-RDW group exhibited longer Los_ICU(4.5 days vs.3.8 days ,respectively, P =0.009) and higher mortality rates at 28 days (33.8% vs. 7.8%, respectively, P <0.001). A nomogram model was created using matched patients which included various factors such as Age, RDW, LDH, CKMB, creatinine and the administration of β-blocker. The C-index predicting 28-day survival probability was 0.846. Decision curves analysis demonstrated that the inclusion of RDW in the model provided a greater net benefit compared to excluding RDW.
Conclusion The prognosis of patients with SIC can be predicted by the RDW value. The nomogram model provides a useful tool in identifying and managing SIC patients.
Takayasu's arteritis associated with tuberculosis: a distinct disease endotype
Authors: Pedreira Ana Luisa Souza , Figueiroa Maria de lourdes Castro de Oliveira , Miranda Mariana Oliveira , de Santana Alisson Regis , Mattos Victor Pereira , Paz Adriane Sousa da , Duran Camila Cendon , Santiago Mittermayer Barreto
Published: February 2024

Background: Takayasu arteritis (TA) and tuberculosis (TB) share similar histopathological and immunological characteristics. Studies comparing patients with TA with or without active or latent TB infection (LTBI) have revealed some differences. This study compared the clinical and radiological features of patients with TA with and without active TB or LTBI.
Methods: We retrospectively analyzed the secondary data of patients with TA at a public tertiary referral outpatient clinic in northeast Brazil from January 2017 to June 2022. Of these, 50 met the eligibility criteria, and an association with TB was identified in 20 patients (40%; active TB in six and LTBI in 14).
Results: Weight loss was more common in patients with TA and TB (p = 0.005). No significant intergroup differences were noted in terms of comorbidities, medications, erythrocyte sedimentation rates, or C-reactive protein levels. Significant differences were found in abdominal aortic involvement (25% of patients with TA and TB; p = 0.013). Dilations (25%) and aneurysms (15.9%) were significantly more common in patients with TA and TB (p = 0.009 and p = 0.027, respectively).
Conclusion: Patients with TA and TB have a higher prevalence of dilatation and aneurysms, most commonly in the abdominal aorta. TA with active TB or LTBI represents a distinct endotype in which vasculitis may arise after an infectious trigger.
TEA SOIL: Self-Power IoT for Precision Soil Farming of Tea Plant Cultivation
Authors: G Santhiya , A Radhakrishnan
Published: February 2024

In agriculture identifying the "nature of the soil" is a significant phase for serval sorts of landscapes. Even though numerous studies have been conducted for continuous soil health monitoring, however, existing techniques face challenges like labor-intensive, cost efficiency, need extensive field sampling and not suitable for tracking of soil parameters. To overcome these issues this paper proposed a novel IoT-based TeaSoil for precision soil monitoring of tea plant cultivation. The proposed TeaSoil’s end nodes are known as Tea Soil Monitoring Units (TSMU), are solar-powered and placed up for extended periods of time. The TSMU wirelessly sends soil NPK sensor, soil temperature, moisture, pH, organic matter, zinc, copper, iron, magnesium, manganese, carbon dioxide (CO2), and geo-location data using SigFox communication. SigFox receives the data and uploads it to the cloud server for data storage and analysis over a long period of time. On this receiver side, the soil classification is carried out using a deep learning-based EfficientNet for tea plant cultivation. A TSMU dashboard allows users to examine gathered data. The proposed Tea soil achieves an overall accuracy of 99.15%. The accuracy of proposed techniques attains 0.75%, 2.16%, and 20.32% better than Fast R-BAG, CNN, and CSMO. It is demonstrated that the proposed TeaSoil is suitable for precision agriculture based on the experimental results.
Research on Information Management of Prefabricated Component Hoisting Construction Based on Dynamo
Authors: Xu Dian , Wang Wenbo , Yi Fei
Published: February 2024

The application of Building Information Modeling (BIM) in the management of prefabricated component lifting operations in prefabricated construction can significantly improve construction efficiency. However, due to its high level of complexity and cost, it has not been widely adopted. To address this issue, this study focuses on the research of lifting operation information management based on Dynamo. By integrating BIM, Dynamo and mobile information management servers, a comprehensive system for managing prefabricated component lifting operation information is created. First, the paper elaborates on the detailed process of prefabricated component lifting operation information management based on Dynamo, covering the construction preparation stage and the lifting construction stage. Subsequently, Dynamo is utilized to develop programs for information input and processing, component sorting, and component coding and QR code generation. Furthermore, a mobile information management server is employed to build an information management application. By scanning Dynamo-generated QR codes, workers can access basic information about components, as well as upload construction and quality inspection data. Furthermore, this application facilitates information sharing and real-time data collection. Finally, this method is tested in a case study involving the lifting operation of composite slabs. The results show that the management system developed based on Dynamo can effectively improve the efficiency of hoisting construction information management prefabricated components of modular construction, reduce management costs, and promote sustainable development of engineering construction.
Clarifying the anatomy of tetralogy of Fallot with S-shaped ascending aorta
Authors: Gupta Saurabh Kumar , Mukharjee Aprateem , Pandey Niraj Nirmal , Ramakrishnan Sivasubramanian , Kothari Shyam Sunder , Saxena Anita , Anderson Robert H
Published: February 2024

Background
We recently encountered several cases of tetralogy of Fallot with an abnormally oriented S-shaped ascending aorta. In this retrospective study, we sought to clarify morphology of this unusual under-recognized variant.
Methods and results
Databases were reviewed to identify all patients with tetralogy of Fallot having an S-shaped ascending aorta. Computed tomographic angiography was used for the assessment of cardiac morphology. Out of the 21 patients, 18 (86%) had a right aortic arch, 2 (9%) had a left aortic arch, and the remaining patient (5%) had a double aortic arch. Patients with a right aortic arch, compared to age and sex-matched patients with a right aortic arch but normally oriented ascending aorta, had lesser aortic override (29.3±14% vs 54.8±13.2%; p = 0.0001) and a wider ascending aorta (25.2±6.9 vs 18.0±3.2 mm; p = 0.0003). The S-shaped ascending aorta was located posteriorly, with a higher sterno-aortic distance (25.5±7.7 vs 9.9±4.5 mm; p = 0.0001). The ascending aorta was longer (4.12±1.7 vs 3.07±0.82, p = 0.03) but with similar tortuosity index (1.22±0.19 vs 1.15±0.17, p = 0.23). Of the cases with right aortic arch and S-shaped ascending aorta, 16 (89%) had extrinsic compression of the right pulmonary artery (p = 0.0001), while 7 (39%) had crossed pulmonary arteries (p = 0.008), with no such findings among those with normally oriented ascending aorta.
Conclusion
Tetralogy of Fallot with an S-shaped ascending aorta is a variant with lesser aortic override and a more posteriorly located ascending aorta. Compression of the right pulmonary artery and crossed pulmonary arteries is frequent in the presence of a right-sided aortic arch.
Direct and Reagentless Atmospheric Pressure Photoionisation Mass Spectrometry: Rapid and Accurate Differentiation of Cystic Fibrosis Related Bacteria by Monitoring VOCs
Authors: Haworth-Duff Adam , Smith Barry L. , Sham Tung-Ting , Boisdon Cedric , Loughnane Paul , Burnley Mark , Hawcutt Daniel B. , Raval Rasmita , Maher Simon
Published: February 2024

Breath analysis is an area of significant interest in medical research as it allows for non-invasive sampling with exceptional potential for disease monitoring and diagnosis. Volatile organic compounds (VOCs) found in breath can offer critical insight into a person’s lifestyle and/or disease/health state. To this end, the development of a rapid, sensitive, cost-effective and potentially portable method for the detection of key compounds in breath would mark a significant advancement. Herein we have designed, built and tested a novel reagent-less atmospheric pressure photoionisation (APPI) source, coupled with mass spectrometry (MS), utilising a bespoke bias electrode within a custom 3D printed sampling chamber for direct analysis of VOCs. Optimal APPI-MS conditions were identified including bias voltage, cone voltage and vaporisation temperature. Calibration curves were produced for ethanol, acetone, 2-butanone, ethyl acetate and eucalyptol, yielding R2 > 0.99 and limits of detection < 10 pg. As a pre-clinical proof of concept, this method was applied to bacterial headspace samples of Escherichia coli (EC), Pseudomonas aeruginosa (PSA) and Staphylococcus aureus (SA) collected in 1 L Tedlar bags. In particular, PSA and SA are commonly associated with lung infection in cystic fibrosis patients. The headspace samples were classified using principal component analysis with 86.9% of the total variance across the first three components and yielding 100% classification in a blind-sample study. All experiments conducted with the novel APPI arrangement were carried out directly in real-time with low-resolution MS, which opens up exciting possibilities in the future for on-site (e.g., in the clinic) analysis with a portable system.
A retrospective analysis of drugs associated with the development of cutaneous squamous cell carcinoma reported by patients on the FDA’s adverse events reporting system
Authors: Jean-Pierre Philippe , Nouri Keyvan
Published: February 2024

Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer arising from squamous cells of the epidermis. Most cases of cSCC have a good prognosis if detected and treated early; however, certain cases can be aggressive. The primary risk factor for cSCC is prolonged ultraviolet radiation from sun exposure, leading to DNA mutations. Other risk factors have also been observed, including adverse reactions to medications, particularly immunosuppressants. A query of the Food and Drug Administration Adverse Events Reporting System (FAERS) was done, and all reported events of cSCC as adverse events to medication were recorded along with demographic data of patients affected. A total of 4,792 cases of cSCC as an adverse event to medication were reported between 1997–2023. Lenalidomide, a chemotherapeutic drug, had the most cases of cSCC as an adverse event. Nine of the top 10 drugs associated with cSCC had immunosuppressive characteristics. While males had higher odds of cSCC associated with corticosteroids and calcineurin inhibitors, females had higher odds of cSCC related to monoclonal antibodies. Geriatric patients accounted for the majority of cSCC cases at 59.7%. Drawing on data from the FAERS database, there’s been a consistent increase in cSCC cases as a side-effect to certain medications, with most having immunosuppressive characteristics. Since there is a lack of up-to-date literature overviewing the most implicated medications for cSCC, we aimed to illustrate this better, as well as patient demographics, to better guide clinicians when prescribing these medications.
Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection
Authors: Milani Amir Eftekhari , Arasteh Amin , Saeedi-Maleki Zahra , Brumandpur Fariborz
Published: February 2024

Background
Retinopathy of prematurity (ROP) is a proliferative disorder of the developing retina. Intravitreal bevacizumab injection (IVB) is an emerging treatment for ROP is one of the treatments for ROP has many benefits. The present study aimed to determine and evaluate the risk factors for ROP recurrence following IVB injection.
Materials and method
In this retrospective study, 98 eyes of 49 infants with ROP who had received IVB injections as the primary treatment for type 1 ROP are included.
Results
Fifty-four eyes (55.1%) had Aggressive posterior retinopathy of prematurity (APROP), and forty-four (44.9%) had Stage III Plus ROP in Zone II. ROP recurred in 13 eyes (13.26%) of 8 infants. The mean period between IVB and the ROP recurrence was 8.08 (95% CI:5.32–10.83) weeks. The infants who had ROP recurrence had lower birth weight (P value = 0.002), lower postmenstrual age at IVB injection (P value = 0.001), lower IVB injection gap period from birth (P value = 0.044), higher oxygen therapy requirement rate after IVB injection (P value < 0.001, OR:19.0) and higher oxygen therapy duration (P value = 0.006). The ROP severity, gestational age at birth, and diet were not statistically different between the recurrence and complete regression groups. Out of 13 eyes treated with laser photocoagulation because of ROP relapse, macula dragging occurred in one eye, and all the cases met the complete regression.
Conclusion
Low birth weight and oxygen therapy are the most important risk factors for ROP relapse, which requires meticulous oxygen treatment guidelines for premature infants.
Generation of a new DiCre expressing parasite strain for functional characterization of Plasmodium falciparum genes in blood stages
Authors: Bansal Abhisheka , Sharma Manish , Choudhury Himashree
Published: February 2024

Conditional regulation is a highly beneficial system to study the function of essential genes in different organisms. Dimerizable Cre recombinase is one of the recently adapted conditional regulation system that has gained huge popularity for the study of essential genes in Plasmodium falciparum. Inactive fragments of Cre are reconstituted to form a functionally active enzyme in presence of rapamycin. Different loci have been targeted for generation of parasite lines that express DiCre enzyme. Here, we have used marker-free CRISPR-Cas9 gene editing to integrate DiCre cassette in a redundant cg6 locus. We have shown the utility of the newly generated ∆cg6DC4 parasites in mediating robust, rapid and highly specific excision of exogenously expressed gfp sequence. The ∆cg6DC4 parasites are also capable of conditional excision of an endogenous parasite gene, PF3D7_1246000. Conditional deletion of PF3D7_1246000 did not cause any inhibition in the asexual proliferation of the parasites. Furthermore, the health and the morphology of the mutant parasites was comparable to that of the control parasites in Giemsa smears. Availability of another stable DiCre parasite strain competent for conditional excision of target genes will expedite functional characterization and validation of novel drug and vaccine targets against malaria.
Model Budaya Pembentukan Karakter Dalam Sistem Pendidikan Di Jerman, Australia
Authors: Balok Servasius
Published: February 2024

Each country has its own strategy for making character development as priority topic in human resource development. At different levels of education, each country makes efforts to implement character education both in the curriculum and in educational practice. So it is very possible that there will be differences in the results and quality of education from one institution to another or one country to another. This difference is what encourages researchers to conduct open studies on the German and Australian cultural models of character formation for the advancement of Indonesian character education. The aim of this research is to describe a comparison of character education in the curricula of three countries, Germany, Australia and Indonesia. This type of research is documentary research and qualitative descriptive methods. And based on analysis of different articles, it was found that these three countries have implemented character education both in their curriculum and in their educational activities. There are similarities and differences in the formation of the personalities of these three nations. These similarities and differences can be seen from three aspects, namely character education in a cultural model, curriculum and character education implementation strategies.
Setiap negara memiliki strategi tersendiri untuk menjadikan pembangunan karakter sebagai topik prioritas dalam pengembangan sumber daya manusia. Pada tingkat pendidikan yang berbeda, setiap negara melakukan upaya untuk menerapkan pendidikan karakter baik dalam kurikulum maupun dalam praktik pendidikan. Sehingga sangat mungkin sekali terjadi perbedaan hasil dan kualitas pendidikan satu lembaga dengan lembaga yang lain atau satu negara dengan negara yang lain. Perbedaan inilah yang mendorong peneliti untuk melakukan kajian secara terbuka terhadap model budaya pembentukan karakter Jerman dan Australia untuk kemajuan pendidikan karakter Indonesia. Tujuan dari penelitian ini adalah untuk mendeskripsikan perbandingan pendidikan karakter dalam kurikulum tiga (3) negara, Jerman, Australia dan Indonesia. Jenis penelitian ini adalah penelitian dokumenter dan metode deskriptif kualitatif. Berdasarkan analisis artikel yang berbeda, ditemukan bahwa ketiga negara tersebut telah menerapkan pendidikan karakter baik dalam kurikulumnya maupun dalam kegiatan pendidikannya. Terdapat persamaan dan perbedaan dalam pembentukan kepribadian ketiga negara tersebut. Persamaan dan perbedaan tersebut dilihat dari tiga aspek, yaitu pendidikan karakter dalam model budaya, kurikulum dan strategi implementasi pendidikan karakter.
Primary Business Value System and Disclosures Paradigm Shift: A Literature Review
Authors: Wamunyima Lindunda
Published: February 2024

The study sought to contribute to the general body of knowledge and research work in primary business value system (PBVS). The research work also aimed to establish the most prominent types of values from the literature and ascertain how PBVS elements are interconnected, their disclosure and impact on business performance. The concept of business values as a system is relatively new. However, this paper’s purpose is to bridge the various pieces of PBVS knowledge in literature by systematically reviewing a collection of articles on the subject and drawing valuable conclusions relating to the various paradigms or schools of thought. The researcher, for this study, identified and critically reviewed thirty (30) old and recent articles on PBVS that were gathered from highly recognized and profiled research databases, including Google Scholar, Research Gate and Elsevier (database), Persistent themes on the prevalent forms of BVS, their interconnectedness in a business establishment. It became clear that defining PBVS exists because of the systematic connectedness of the core values. There is enough evidence from the literature that when implemented well, PBVS yields effective connectedness of the core values to render a company a unity whole and consequently, make business sense.
Developing Uplink Power Optimization and ARS Selection Algorithm for Multi-ARS Small Cell Communication System
Authors: Be Hoai Thi Bich , Bui Duc Anh , Pham Hiep Thanh , Nguyen Phuong Thu
Published: February 2024

Small Cell (SC) models and unmanned aerial vehicles (UAVs) acting as aerial relay stations (ARSs) are both promising advancements in the development of upcoming wireless networks that contribute significantly to improving the overall service quality. In this work, we rely on the Multi-ARS Cell-Free (CF) model, where a large number of ARS coordinated by the ground base station (GBS) and cooperate to serve a large number of users within the same frequency and time resources, to develop the uplink of a multi-ARS SC system, in which each user is served by only one ARS. The time division duplex (TDD) mechanism is used for communication protocol, and the Minimum Mean Square Error (MMSE) method is implemented to estimate the uplink channel. We derive an closed-form expression for uplink user throughput. In addition, we introduce the ARS selection method based on channel conditions and propose the Bisection algorithm to optimize uplink power. The system performance is evaluated by the cumulative distribution function (CDF) of user throughput according to different parameters, such as changing the number of ARS, the number of users, the number of antennas, and the length of pilot sequences with/without power optimization. The results reveal that the ARS selection method is effectively resolved to reduce complexity and improve the practicality of the proposed system, and the power optimization problem for better throughput is non-optimization.
An innovative method for estimating settling velocity of particles in stormwater using absorbance measurements and modelling
Authors: Haghighatafshar Salar , Hallinger Emma , Espinoza Daniel , Al-Rudainy Basel
Published: February 2024

The purpose of the study was to develop a simple and rapid method for measuring the average settling velocity of particles in stormwater ponds. Water samples with suspended particles were collected from the bottom of a stormwater pond in Lund, Sweden. The absorbance in various samples was measured over 24 h (at 600 nm wavelength) and then translated into total solids concentrations. A one-dimensional model based on the Mason–Weaver equation was coded in Python and solved. The absorbance measurements were used to calibrate the model, thereby quantifying settling velocities and dispersion coefficients for samples from different zones of the stormwater pond. The quantified settling velocities ranged from 40 to 200 mm/h for fast-settling particles and from 2 to 8 mm/h for slow-settling particles. The developed methodology provided a mass estimate of the two modelled particle groups (i.e., fast- and slow-settling particles). Based on the model estimates, fast-settling particles dominated all samples, constituting 70–90% of the total solid mass. Due to its simplicity and inexpensiveness, this methodology is a potential alternative to more demanding and complicated methodologies used for measuring particle velocities in sedimentation systems.
Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic
Alternatives
Authors: Maziero Maria Paula , Rocha Natalia P. , Teixeira Antonio L.
Published: February 2024

Psychosis and hyperactive behaviors, such as agitation and wandering, affect a significant
proportion of patients with Alzheimer’s disease (AD). These symptoms are often treated with
antipsychotics, usually in an off-label approach. This mini-review provides an updated perspective
on the pharmacological approach for the neuropsychiatric symptoms (NPS) in AD. The results of
new studies have provided a better understanding of AD-related NPS management, but high-quality
evidence still needs to be obtained. Herein, we argue for a more cautious approach to the use of
antipsychotics in AD and highlight the importance of exploring alternative treatments for NPS. By
doing so, we can ensure that patients with AD receive optimal care that is both effective and safe.
Characterization of Intrinsically Disordered Proteins in Healthy and
Diseased States by Nuclear Magnetic Resonance
Authors: Shahrajabian Mohamad Hesam , Sun Wenli
Published: February 2024

Introduction:

Intrinsically Disordered Proteins (IDPs) are active in different cellular
procedures like ordered assembly of chromatin and ribosomes, interaction with membrane, protein,
and ligand binding, molecular recognition, binding, and transportation via nuclear pores, microfilaments
and microtubules process and disassembly, protein functions, RNA chaperone, and
nucleic acid binding, modulation of the central dogma, cell cycle, and other cellular activities,
post-translational qualification and substitute splicing, and flexible entropic linker and management
of signaling pathways.

Methods:

The intrinsic disorder is a precise structural characteristic that permits IDPs/IDPRs to be
involved in both one-to-many and many-to-one signaling. IDPs/IDPRs also exert some dynamical
and structural ordering, being much less constrained in their activities than folded proteins. Nuclear
magnetic resonance (NMR) spectroscopy is a major technique for the characterization of
IDPs, and it can be used for dynamic and structural studies of IDPs.

Results and Conclusion:

This review was carried out to discuss intrinsically disordered proteins
and their different goals, as well as the importance and effectiveness of NMR in characterizing intrinsically
disordered proteins in healthy and diseased states.
Analysis of Developing Anti-Corruption Education in Indonesia Through Media-Based Citizenship Education Learning Smart Mobile Civic
Authors: Trisiana Anita , Priyanto Anang , Sutoyo Sutoyo
Published: February 2024

The purpose of this study is to analyze the development of anti-corruption education in Indonesia, through learning Citizenship Education based on Smart Mobile Civic media. Efforts to eradicate corruption are not only the responsibility of law enforcement agencies or the government, but also the responsibility of all components of the nation. Therefore, efforts to eradicate corruption must be carried out by involving all relevant stakeholders, namely the government, the private sector and the community. This research method uses a qualitative approach. The use of qualitative methods in research can produce a more comprehensive study of a phenomenon. The results of the study show that: Citizenship Education learning system has a very strategic role, to increase students' understanding of anti-corruption education. In this context of research, the students, as agents of corruption prevention, cannot be separated from the characteristics they possess, such as: Intellectuality, Youth Spirit, and Idealism. Student involvement in the anti-corruption movement can basically be divided into four areas: within the family, on campus, in the local community, and at the regional or national level. The digital era has had a tremendous impact on citizenship learning, such as through the application of Smart Mobile Civic media as a fun and not boring learning media for students so that they can explore more deeply about their knowledge and experiences.
Building the Foundation for Creativity and Collaboration: Knowledge Sharing Learning Models
Authors: Mustaqim Ilmawan , Setyosari Punaji , Kamdi Waras , Ulfa Saida
Published: February 2024

The integration of creativity, critical thinking, collaboration, and communication skills into 21st-century learning represents a pivotal goal in education, particularly within the realms of engineering. Despite this ambition, the actualization of creativity and collaborative capabilities among engineering students remains a significant challenge, primarily due to prevalent individualistic attitudes and apprehensions towards error in idea sharing. This study introduces and evaluates a Knowledge Sharing (KS) learning model aimed at overcoming these barriers, thereby facilitating enhanced creativity and collaboration. Employing the Akker learning stages, this model was implemented in an engineering education setting, yielding encouraging outcomes: students demonstrated increased motivation for interdisciplinary learning, acquired novel knowledge beyond their traditional curricula, and developed practical designs and tools responsive to community needs. The methodology section details the iterative process of model development, encompassing identification, design and preparation, implementation, replication, and dissemination phases, followed by a thorough validation process. Results indicate a positive impact on students' creative competencies and collaborative skills, underscoring the model's efficacy in fostering essential 21st-century skills.
Does school climate matter in cyberbullying behaviour among high school student? A mediation and moderation analysis
Authors: Maftuh Bunyamin , Dahliyana Asep , Malihah Elly , Sartika Rika
Published: February 2024

Information technology development has had positive and negative impacts on the education sector. One of the negative impacts is the emergence of new bullying behaviour by utilizing information technology online or cyberbullying behaviour. Previous studies have examined that cyberbullying is often associated with school climate, psychological capital, and social media addiction. However, until now, limited studies still discuss mediation and moderation relationships between school climate factors, psychological capital, social media addiction, and student cyberbullying behaviour. This study involved 384 high school students from six public and private high schools in Magelang, Indonesia. The study's results explain that cyberbullying behaviour is influenced by school climate and students' psychological capital. Psychological capital is positively influenced by school climate. In addition, psychological capital has successfully mediated the effects of school climate on high school students' cyberbullying behaviour. And finally, social media addiction is proven to moderate the effects of school climate and high school students' cyberbullying behaviour.
Increasing Social Care Through Civic Education in Higher Education
Authors: Suyato Suyato , Hidayah Yayuk -
Published: February 2024

This study aims to build social care through an engagement-based Civic Education curriculum at Universitas Negeri Yogyakarta/UNY whose students have diverse backgrounds. This study was developed based on the qualitative approach through 1) a focus group discussion to examine the engagement learning model in the Civic Education curriculum, 2) a workshop on the development of engagement learning models, 3) expert validation using the engagement learning model instrument, 4) implementation of engagement learning model, and 5) reflections on the engagement learning model implementation. The results of this study show that the Engagement Learning Model can improve social care shown from mutual respect for diversity, social cohesion, sympathy for others, and volunteerism. The researcher used the social value theory to analyze students’ social care. This engagement learning model can develop a social collaboration that promotes the unique characteristics of each student. Students are trained to be critical and socially sensitive through an engagement project consisting of social activities in the community in Civic Education learning. Increasing students' care from Civic Education may positively influence students' knowledge, attitudes, and social relations in their groups and outside their groups, respect and acceptance of diversity, social cohesion that forms cooperation, sympathy for others that form social solidarity, as well as a sense of volunteerism that makes students provide solutions to social problems.
News Coverage of the COVID-19 Pandemic on Social Media and the Public’s Negative Emotions: Computational Study
Authors: Wang Hanjing , Li Yupeng , Ning Xuan
Published: February 2024

Background

Social media has become an increasingly popular and critical tool for users to digest diverse information and express their perceptions and attitudes. While most studies endeavor to delineate the emotional responses of social media users, there is limited research exploring the factors associated with the emergence of emotions, particularly negative ones, during news consumption.

Objective

We aim to first depict the web coverage by news organizations on social media and then explore the crucial elements of news coverage that trigger the public’s negative emotions. Our findings can act as a reference for responsible parties and news organizations in times of crisis.

Methods

We collected 23,705 Facebook posts with 1,019,317 comments from the public pages of representative news organizations in Hong Kong. We used text mining techniques, such as topic models and Bidirectional Encoder Representations from Transformers, to analyze news components and public reactions. Beyond descriptive analysis, we used regression models to shed light on how news coverage on social media is associated with the public’s negative emotional responses.

Results

Our results suggest that occurrences of issues regarding pandemic situations, antipandemic measures, and supportive actions are likely to reduce the public’s negative emotions, while comments on the posts mentioning the central government and the Government of Hong Kong reveal more negativeness. Negative and neutral media tones can alleviate the rage and interact with the subjects and issues in the news to affect users’ negative emotions. Post length is found to have a curvilinear relationship with users’ negative emotions.

Conclusions

This study sheds light on the impacts of various components of news coverage (issues, subjects, media tone, and length) on social media on the public’s negative emotions (anger, fear, and sadness). Our comprehensive analysis provides a reference framework for efficient crisis communication for similar pandemics at present or in the future. This research, although first extending the analysis between the components of news coverage and negative user emotions to the scenario of social media, echoes previous studies drawn from traditional media and its derivatives, such as web newspapers. Although the era of COVID-19 pandemic gradually brings down the curtain, the commonality of this research and previous studies also contributes to establishing a clearer territory in the field of health crises.
Habermas’ Concept of “Lebenswelt” and System and Its Implication for the Position of Religion in Public Life
Authors: Sunaryo Sunaryo
Published: February 2024

The concept of “Lebenswelt” (the lifeworld) and the system are essential in Jürgen Habermas's thought. Habermas understands Lebenswelt as background knowledge that people take for granted naively. It becomes the horizon of their daily communication. He emphasizes the importance of coupling Lebenswelt and system. The uncoupling will make society get loss of meaning. Then we ask how he understands the position of religion in public life. How should we place religion as a part of Lebenswelt in making public law? To answer the question, we did the library research by exploring Habermas's works and his commentators. Then I conclude that Habermas offers accommodative participation to religion in public life through discourse. In the discourse, views inspired by religion can be put forward in the public sphere as far as they undergo a rationalization process. They should be openly discussed and tested instead of being taken for granted naively. Views inspired by religion will be accepted as long as they are rational. Discourse practice requires religious groups to be more mature and rational in formulating their ideas in the public sphere. Religious ideas are no longer positioned as closed and anti-criticism.
Proteção previdenciária do risco idade no direito positivo brasileiro
Authors: Deda Gonçalves Ionas
Published: February 2024

O artigo discorre sobre a proteção previdenciária do risco idade avançada, dando especial enfoque no direito positivo brasileiro. Inicia com considerações sobre a importância do evento idade avançada no contexto da seguridade social e os desafios conjunturais enfrentados na fixação de políticas previdenciárias que sejam socialmente adequadas e economicamente viáveis. Em seguida, tece considerações sobre o risco na doutrina de seguridade social. O direito positivo brasileiro é objeto de análise desde a Constituição de 1988, que contém disposições detalhadas sobre previdência social, passando pela lei ordinária regulamentadora e pelo decreto do Executivo que tem a função de lhe dar fiel execução. A partir da decomposição analítica da norma jurídica instituidora do benefício, é traçada a regra-matriz de incidência, estrutura lógica que permite identificar todos os elementos componentes da hipótese de incidência e dos elementos componentes da relação jurídica previdenciária. Nos últimos itens são feitas considerações sobre carência, efeito sobre o contrato de trabalho e sobre a dinâmica da relação jurídica previdenciária.
Seguridad social en Guatemala
Authors: Valenzuela Herrera Augusto
Published: February 2024

Cuando se aborda el tema de seguridad social debe considerarse a la solidaridad como su filosofía subyacente. Ésta resulta de la natural necesidad humana de seguridad y encuentra sus raíces en lo más profundo de los seres humanos. La seguridad social entendida como la máxima expresión de solidaridad y conciencia colectiva apunta a satisfacer las necesidades humanas y alcanzar el bienestar mediante la colaboración recíproca y solidaria de la sociedad para con sus integrantes; evoluciona al ritmo de la humanidad y debe ser constantemente revisada para adaptarla, lo más posible, a las nuevas necesidades. Dados sus fundamentos, la seguridad social se encuentra provista de un dinamismo que justifica la renovación constante de los sistemas de seguridad social y, por ende, su reforma. Sólo la solidaridad y el estudio del contexto social y económico de cada país pueden sugerir un modelo que, como “traje a la medida”, responda a las necesidades de las sociedades modernas.
La capacitación y adiestramiento en México: regulación, realidades y retos
Authors: Sánchez-Castañeda Alfredo
Published: February 2024

El presente artículo hace un estudio del estado del arte de la legislación en materia de capacitación y adiestramiento en México, así como de los programas, consejos y sistemas existentes al respecto. Luego de señalar algunos desafíos que debe afrontar la formación profesional en el país, el autor señala la importancia de contar con una capacitación y adiestramiento a lo largo de la vida del trabajador, la cual, propone, debe desarrollarse en tres niveles profundamente relacionados, además de señalar el papel que deben jugar los actores sociales y la necesidad de evaluar permanentemente a las entidades y a los programas encargados de la formación profesional.
Implicaciones fiscales de la seguridad social
Authors: Moreno Padilla Javier
Published: February 2024

En el presente artículo se explica la naturaleza jurídica de las cuotas obrero-patronales; para ello se recurre a los antecedentes y al denominado “hecho generador”, para confirmar el carácter fiscal de las aportaciones de seguridad social del seguro social y del Infonavit. Asimismo, con base en este concepto se abordan los sistemas de retiro y los capitales constitutivos como créditos fiscales atípicos en materia de seguridad social. Finalmente se analizan las características de los organismos fiscales autónomos y se determinan las propias del IMSS e Infonavit.
El pacto de Toledo como mecanismo de revisión de los sistemas de pensiones en España
Authors: Abellana Ch. Mónica , Delgado C. Aura Adriana
Published: February 2024

Los sistemas europeos más avanzados en cuanto a sistemas de pensiones tenían respecto a España un nivel de partida, en términos de prestaciones, mayor, aunque era evidente que se asentaban en mayores cotizaciones. A partir de la firma del Pacto de Toledo se han producido en España acuerdos sociales importantes: se amplió el cálculo de la vida laboral para tener en cuenta las pensiones; se incrementaron las pensiones más bajas; se creó un Fondo de Reserva y se alargó la vida laboral. El presente trabajo analiza la situación de la seguridad social en España antes del consenso de 1995, a través del cual nace el Pacto como mecanismo de revisión de los sistemas de pensiones y como iniciativa innovadora, ahondando en las recomendaciones surgidas para luego describir las recomendaciones realizadas por los expertos acerca de la renovación del Pacto hasta la actualidad
Principios procesales necesarios en la administración de justicia en asuntos laborales y por prestaciones de la seguridad social en México
Authors: Ruiz Moreno Ángel Guillermo
Published: February 2024

Pese a que el proceso laboral mexicano es por disposición legal predominantemente oral, en la práctica es fácil advertir que no se cumple a cabalidad con los principios procesales de la oralidad ni de la inmediatez. Resabios del proceso civil romano germánico, de naturaleza privada y escrito, siguen incidiendo ineluctablemente en la tramitación de los juicios del orden laboral, lo que es extensivo al rubro prestacional de la seguridad social. Mediante el estudio y comprensión de las razones que históricamente han llevado a estructurar los procesos laborales y su inevitable evolución, basado en los principios procesales que les corresponde a este tipo de juicios, se pretende poner de nuevo en el tapete de las discusiones jurídicas la instrumentación de un proceso laboral que tienda a alcanzar una mejor administración de justicia entre los factores de la producción (capital y trabajo), así como una más expedita cuanto equitativa aplicación de justicia en materia de prestaciones de la seguridad social básica.
Derecho procesal del trabajo: principios, naturaleza, autonomía y jurisdicción
Authors: Santos Azuela Héctor
Published: February 2024

En el presente artículo se estudia la autonomía científica y didáctica de derecho procesal del trabajo a partir de la premisa del alcance y perspectivas de la teoría general del proceso laboral. De esta suerte, se analiza el significado y el alcance de la acción, jurisdicción y proceso laborales. Por lo mismo es que se aborda el estudio de los sujetos fundamentales del proceso del trabajo, pormenorizando en la temática de la personalidad y la capacidad de las partes. Asimismo, se analiza la genealogía, carácter y expectativas de la jurisdicción laboral, en su sorprendente tránsito de los tribunales de equidad a los de estricto derecho, distinguiéndolos técnicamente de los tribunales de conciencia, con los que frecuentemente suelen confundirse erróneamente. Finalmente, se contrastan y tratan de elucidarse las diferencias que existen entre las controversias y los conflictos de trabajo, enfatizando la necesidad de ponderar el concepto del litigio dentro de esta disciplina.