bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial intelligence in capsule endoscopy: development status and future expectations
Authors: George Ashwin A. , Tan Jin Lin , Kovoor Joshua G. , Lee Alvin , Stretton Brandon , Gupta Aashray K. , Bacchi Stephen , George Biju , Singh Rajvinder
Published: March 2024

In this review, we aim to illustrate the state-of-the-art artificial intelligence (AI) applications in the field of capsule endoscopy. AI has made significant strides in gastrointestinal imaging, particularly in capsule endoscopy - a non-invasive procedure for capturing gastrointestinal tract images. However, manual analysis of capsule endoscopy videos is labour-intensive and error-prone, prompting the development of automated computational algorithms and AI models. While currently serving as a supplementary observer, AI has the capacity to evolve into an autonomous, integrated reading system, potentially significantly reducing capsule reading time while surpassing human accuracy. We searched Embase, Pubmed, Medline, and Cochrane databases from inception to 06 Jul 2023 for studies investigating the use of AI for capsule endoscopy and screened retrieved records for eligibility. Quantitative and qualitative data were extracted and synthesised to identify current themes. In the search, 824 articles were collected, and 291 duplicates and 31 abstracts were deleted. After a double-screening process and full-text review, 106 publications were included in the review. Themes pertaining to AI for capsule endoscopy included active gastrointestinal bleeding, erosions and ulcers, vascular lesions and angiodysplasias, polyps and tumours, inflammatory bowel disease, coeliac disease, hookworms, bowel prep assessment, and multiple lesion detection. This review provides current insights into the impact of AI on capsule endoscopy as of 2023. AI holds the potential for faster and precise readings and the prospect of autonomous image analysis. However, careful consideration of diagnostic requirements and potential challenges is crucial. The untapped potential within vision transformer technology hints at further evolution and even greater patient benefit.
Microbial influence on blood pressure: unraveling the complex relationship for health insights
Authors: Cardoso Alexander Machado
Published: March 2024

Hypertension, a critical global health concern, is characterized by persistent high blood pressure and is a major cause of cardiovascular events. This perspective explores the multifaceted implications of hypertension, its association with cardiovascular diseases, and the emerging role of the gut microbiota. The gut microbiota, a dynamic community in the gastrointestinal tract, plays a pivotal role in hypertension by influencing blood pressure through the generation of antioxidant, anti-inflammatory, and short-chain fatty acids metabolites, and the conversion of nitrates into nitric oxide. Antihypertensive medications interact with the gut microbiota, impacting drug pharmacokinetics and efficacy. Prebiotics and probiotics present promising avenues for hypertension management, with prebiotics modulating blood pressure through lipid and cholesterol modulation, and probiotics exhibiting a general beneficial effect. Personalized choices based on individual factors are crucial for optimizing prebiotic and probiotic interventions. In conclusion, the gut microbiota’s intricate influence on blood pressure regulation offers innovative perspectives in hypertension therapeutics, with targeted strategies proving valuable for holistic blood pressure management and health promotion.
Past, present, and future of microbiome-based therapies
Authors: Manrique Pilar , Montero Ignacio , Fernandez-Gosende Marta , Martinez Noelia , Cantabrana Claudio Hidalgo , Rios-Covian David
Published: March 2024

Technological advances in studying the human microbiome in depth have enabled the identification of microbial signatures associated with health and disease. This confirms the crucial role of microbiota in maintaining homeostasis and the host health status. Nowadays, there are several ways to modulate the microbiota composition to effectively improve host health; therefore, the development of therapeutic treatments based on the gut microbiota is experiencing rapid growth. In this review, we summarize the influence of the gut microbiota on the development of infectious disease and cancer, which are two of the main targets of microbiome-based therapies currently being developed. We analyze the two-way interaction between the gut microbiota and traditional drugs in order to emphasize the influence of gut microbial composition on drug effectivity and treatment response. We explore the different strategies currently available for modulating this ecosystem to our benefit, ranging from 1st generation intervention strategies to more complex 2nd generation microbiome-based therapies and their regulatory framework. Lastly, we finish with a quick overview of what we believe is the future of these strategies, that is 3rd generation microbiome-based therapies developed with the use of artificial intelligence (AI) algorithms.
THE EFFECTS OF ENVIRONMENTAL PECULIARITIES ON TRANSPORTATION INFRASTRUCTURE PERFORMANCE IN LAGOS METROPOLIS, NIGERIA: RESIDENTS' EXPERIENCES
Authors: AKANMU Ayobami Ademola , SALISU Umar Obafemi
Published: March 2024

Efficient transportation infrastructure is pivotal for the seamless functioning of global cities, with coastal cities facing unique challenges due to environmental peculiarities. This study delves into how Lagos' environmental peculiarities impact transportation infrastructure performance, shedding light on both positive and negative implications. A comprehensive survey involving 1284 residents within Lagos Metropolis was conducted using multistage sampling techniques. A combination of descriptive (percentage and mean-weighted analysis) and inferential (Fisher’s exact test and Phi Cramer's V Test) statistics was adopted for data analysis. Major findings revealed that the environmental peculiarities in Lagos foster the use of multimodal infrastructure options and concurrently exert adverse effects on various facets of transportation infrastructure performance, including travel cost, commuting time, fare charges, wear and tear of infrastructure, and the overall cost of maintenance and repairs. The results of the Fisher’s exact test underscore the undeniable impact of Lagos' environmental peculiarities on transportation infrastructure performance (p = 0.000 < 0.05). This study concludes that high water tables, as a representative environmental peculiarity, substantially influence transportation infrastructure performance, shaping the mobility needs of residents. In light of these findings, the study advocates for the full implementation of sustainable infrastructure solutions. Recommendations include establishing robust drainage systems, incorporating corrosion-resistant materials, and adopting innovative technologies to mitigate the repercussions of rising sea levels on critical transportation infrastructure, enhancing its resilience in the face of environmental challenges.
NEW STRATEGY THE FOR DESIGNATION OF THE INTEGRITY PARAMETER IN SBAS POSITIONING IN AIR TRANSPORT
Authors: MROZIK Magda , KOZUBA Jarosław , KRASUSKI Kamil , ĆWIKLAK Janusz , BAKUŁA Mieczysław , BELDJILALI Bilal
Published: March 2024

The article shows the results of a study on the determination of SBAS satellite positioning integrity parameters as a HPL and VPL protection levels. To this end, a modified algorithm was developed to determine the HPL and VPL protection levels from a common aircraft position navigation solution based on EGNOS and SDCM augmentation systems. The developed mathematical scheme was verified on real GNSS kinematic data recorded by two onboard Septentrio AsterRx2i and Trimble Alloy receivers installed on a Diamond DA 20-C aircraft. Based on the conducted tests, it was found that the HPL parameter does not exceed 12.24 m, while respectively the VPL does not exceed 18.01 m. In addition, in the course of the study it was found that the proposed EGNOS+SDCM solution improves the HPL/VPL integrity determination in relation to the EGNOS solution by 8÷66%. The mathematical scheme used in the study was also applied to designation the HPL/VPL terms for the UAV platform. The obtained results of the HPL/VPL values for the positioning of the aircraft and the UAV platform show a high efficiency of the developed algorithm for improving the integrity parameter.
ARTIFICIAL INTELLIGENCE AS A BASIC PROBLEM WHEN IMPLEMENTING AUTONOMOUS VEHICLE TECHNOLOGY IN EVERYDAY LIFE
Authors: CZECH Piotr
Published: March 2024

Innovative technologies that use artificial intelligence in transport solutions recently emerging around the world include, among others issues of autonomous vehicle driving. The use of autonomous vehicle technology affects the issues of civil liability (liability and insurance), road safety, natural environment (energy efficiency, renewable energy sources), data (access, exchange, protection, privacy), IT infrastructure (effective and reliable communication), employment (creation and loss of jobs, training of truck drivers in the use of automated vehicles). The development of new technologies related to artificial intelligence, including autonomous vehicles, generates inevitable changes in law, economy and society. It is inevitable due to the fact that autonomy is undoubtedly a means to achieve the goal of improving the efficiency sought in every area of life. The article presents arguments confirming the thesis that the basic factor inhibiting the implementation of autonomous vehicle technology is the problem of artificial intelligence, including its definition and legal regulation.
Detecting Reinforced Concrete Rebars Using Ground Penetrating Radars
Authors: Zatar Wael A. , Nghiem Hien , Nguyen Hai
Published: March 2024

A new algorithm is developed in this study to automatically detect reinforced concrete structures' rebar locations and diameters using the ground penetrating radar technique. The method approximates the hyperbolic signatures using two-way travel time and bi-quadratic equations. The study includes formulating electromagnetic wave speed in reinforced concrete (RC) structures. The algorithm was used in a computer code to provide an automated analysis of ground-penetrating radar data collected from a pre-planned survey grid. Two RC slabs were fabricated and tested to validate the proposed method. The proposed method is efficient in signal processing and accurately and reliably determining the rebar information.
Investigation of Health-Related Quality of Life, Anxiety and Satisfaction in Patients with Pulmonary Embolism during the COVID-19 Pandemic
Authors: Malli Foteini , Papamichali Diamantoula , Vlaikoudi Nikoletta , Papathanasiou Ioanna V. , Evangelos Fradelos C. , Papagiannis Dimitrios , Rouka Erasmia C. , Raptis Dimitrios G. , Daniil Zoe , Gourgoulianis Konstantinos I.
Published: March 2024

Background: Features of post-traumatic stress disorder and anxiety may be present in Pulmonary Embolism (PE) patients along with impaired Quality of Life (QoL). We aim to evaluate health related QoL, anxiety and satisfaction with life, during the pandemic, in patients with a PE. Methods: Patients with PE were enrolled during their follow-up. All participants completed the Short Form 36 (SF-36) questionnaire, the State Trait Anxiety Inventory (STAI) X1 and X2 form, and the Satisfaction with Life Scale (SWLS). Results: 92 PE patients were included (mean age±SD=62.50±15.33 years, 56.5% males). Most of the mean values of the SF36 subscales were above the normative value except for “physical role functioning”) (45.92±42.41). “Emotional role functioning” (51.26±43.31) and “general health perceptions” (GH) (54.02±18.79) were slightly above the normative value of 50. Mean STAIX1 levels were 37.05±11.17 and mean STAIX2 levels were 39.80±10.47. Mean SWLS levels were 23.31±6.58. According to multiple linear regression analysis, mental healthscore (MH) and GH were predictive of SWLS(F (10,76) = 10.576, p
High Throughput Determination of Infectious Virus Titers by Kinetic Measurement of infection-Induced Changes in Cell Morphology
Authors: Hotter Dominik , Kunzelmann Marco , Kiefer Franziska , Leukhardt Chiara , Fackler Carolin , Jaeger Stefan , Solzin Johannes
Published: March 2024

Infectivity assays are the key analytical technology for development of manufacturing processes for virus-based therapeutics. Here, we introduce a novel assay format that utilizes label-free bright field images to determine the kinetics of infection-dependent changes in cell morphology. In particular, cell rounding is directly proportional to the amount of infectious virus applied, enabling rapid determination of viral titers in relation to a standard curve. Our kinetic infectious virus titer (KIT) assay is stability-indicating and, due to its sensitive readout method, provides results within 24 hours post-infection. Compared to traditional infectivity assays, which depend on a single readout of an infection endpoint, cumulated analysis of kinetic data by a fit model results in precise results (CV < 20%) based on only three wells per sample. This approach allows for a high throughput with ~400 samples processed by a single operator per week. We demonstrate the applicability of the KIT assay for VSV-GP and NDV, but it can potentially be extended to a wide range of viruses that induce morphological changes upon infection. The versatility of this assay, combined with its independence from specific instruments or software, makes it a promising solution to overcome the analytical bottleneck in infectivity assays within the pharmaceutical industry and as a routine method in academic research.
Vaccine-Induced Viral Reactivation and Autism Spectrum Disorder: A Review, Hypothesis and Implications.
Authors: Uncensored Health
Published: March 2024

Understanding the origins of autism spectrum disorder is imperative given its increasing prevalence and significant global impact. This review examines existing research on the role of viral infections in the etiology of autism and scrutinizes emerging data on post-vaccination viral reactivation. It introduces a novel hypothesis, that vaccines may inadvertently reactivate latent viral infections, triggering the onset or exacerbation of autism. Through a comprehensive literature review across multiple databases and search engines, this review analyzed studies, case reports, and observational research focusing on viral infections, post-vaccination viral reactivation, and autism. This search yielded 12 studies implicating viral infections and viral encephalitis as potential causal factors in the development of autism spectrum disorder. Moreover, 10 studies were identified suggesting an association of viral reactivation following vaccination. This connection raises important questions about the potential role of vaccines in the onset of autism. The findings advocate for continued vigilance in vaccine safety research, particularly concerning neurodevelopmental disorders.
Evaluate the Impact of the Long-Term Care Insurance (LTCI) System on Older Adults in Japan
Authors: Miao Chuhan , Li Beilei , He Jianxun
Published: March 2024

Objective: The long-term care insurance (LTCI) system was introduced in 2000 to provide financial support for long-term care services to older adults. What is known on this topic report focuses on a comparative analysis of how the LTCI system has affected older people in Japan. Methods: We obtained data from the literature about the LTCI system, compared and analysed the collected articles, and concluded. Results: The LTCI system has improved access to long-term care services, with more older adults receiving care than before the system’s implementation. This service has improved the quality of life for many elderly individuals who require assistance with daily activities. Furthermore, the LTCI system has alleviated the financial burden of long-term care services since the insurance covers a large portion of the costs. It has made older adults maintain their independence and dignity, as they can afford the necessary care without relying solely on their savings or burdening their families. Conclusions: Japan’s LTCI system has positively impacted older adults by improving access to long-term care services and alleviating financial burdens. However, challenges such as increasing demand and variations in service quality need to be addressed to ensure the system effectively supports older people in Japan.
Precision Medicine Approaches in Acute Myeloid Leukemia with Adverse Genetics
Authors: Santoro Nicole , Salutari Prassede , Di Ianni Mauro , Marra Andrea
Published: March 2024

The treatment of acute myeloid leukemia (AML) with adverse genetics remains unsatisfactory, with very low response rates to standard chemotherapy and shorter durations of remission commonly observed in these patients. The complex biology of AML with adverse genetics is continuously evolving. Herein, we discuss recent advances which have investigated the contribution of cell intrinsic mechanisms as well as of the immune system to myeloid leukemogenesis in this specific subset of AML. We focus on the biological rationales for combining targeted therapy and immunotherapy, which are currently being investigated in ongoing trials, and could hopefully ameliorate the poor outcomes for these patients
A Proposal of Geoengineering Method as Global Warming Countermeasure：
Stratospheric O3 Increase to Reduce Earth＇s Surface Temperature
Authors: Ohmori Takashi
Published: March 2024

A method of geoengineering/solar radiation management is proposed as global warming countermeasure. The idea is to decrease surface temperature by increasing stratospheric ozone. One-dimensional (vertical) radiative-convective equilibrium temperature calculations show that surface temperature can be lowered by increasing the amount of ozone in the stratosphere. It was the increase in altitude above about 25 km that reduced surface temperatures. The method of increasing the amount of ozone (O3 injection), the rate of decrease of surface temperature after the ozone increase, and the rate of decrease of ozone concentration by photochemical reaction and diffusion/transport after the ozone increase are discussed.
Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician
Authors: Karatza Ageliki A , Fouzas Sotirios , Gkentzi Despoina , Kostopoulou Eirini , Oikonomou Nikoleta , Dimitriou Gabriel , Sinopidis Xenophon
Published: March 2024

Primary care pediatricians encounter a wide range of complex conditions in their daily clinical practice. It is not uncommon for their patients to get exposed to medical errors. Diagnostic errors, defined as missed, delayed, or wrong diagnosis, are of great importance as they may cause significant harm to the pediatric patient with severe disease. These errors often occur when the symptoms and signs of a disease are atypical or missing. Data on the most frequent misdiagnosed situations in pediatrics is scarce. One of these groups of conditions is that regarding cardiac diseases. The pediatric cardiology field has met rapid development over the past few decades. Primary care providers play a key role in diagnosis, management, and referral of children with heart disease, both congenital and acquired, because many common cardiac complaints are first addressed in the primary care setting. The scope of this review is to investigate the cardiac entities that are often missed by the general pediatricians. In particular, it aims to spot the most common of them, to describe their clinical presentation, their diagnostic options, red flags, and tips, and to provide the ways to avoid erroneous, delayed, or missed diagnosis.
Intestinal Bacteria Community Structures of Ruditapes philippinarum and Their Correlation with Environmental Factors
Authors: Zhao Chenyang , Zhao Xinyan , Li Jiaxi , Chen Yingxu , Liu Shang , Fang Lei , Huo Zhongming
Published: March 2024

The intestinal microbial community of aquatic animals is closely related to the environment and thus affects the health of aquatic animals. Here we investigated annual variation of intestinal bacteria community structures of Ruditapes philippinarum cultured using two different methods, bottom sown and raft hanging. Bacterial diversity of seawater and sediment in different seasons was examined as well. Correlation between R. philippinarum intestinal bacteria community structures and environmental factors was analyzed. The results showed that in the two aquculture areas where R. philippinarum was differentially cultured, bacteria community structure of seawater and sediment both altered with seasons. However, neither seasonal changes nor difference in culture methods could significantly affect the intestinal bacteria community structures of R. philippinarum. Additionally, in terms of the alpha diversity of intestinal bacteria communities, there was no significant difference in R. philippinarum cultured using the two methods. For benthic cultured clams, alpha diversity of the intestinal bacterial communities was often higher than that of the environmental bacterial communities. For raft hanging cultured calms, Alpha diversity of the intestinal bacterial communities was normally comparable with that of the environmental counterparts. Beta diversity analysis showed that the intestinal bacterial community structure of R. philippinarum was mainly determined by both deterministic and stochastic processes. Correlation analysis showed that the intestinal bacterial community structures of R. philippinarum were determined by a variety of environmental factors. For clams collected from the benthic culture area, the intestinal bacterial structure was more correlated with the physicochemical properties of sediment in comparing with those of seawater. For clams collected from the raft-culture area, the intestinal bacterial structure was mainly determined by the phsicochemical characteristics of seawater. This study helps us to better understand the bacterial community structure in complex aquaculture ecosystems, providing a reference for healthy shellfish aquaculture and ecosystem protection in aquaculture area.
Comprehensive Analysis of Leucine-rich Repeat Receptor-like Pro-teins Provides Insights into Their Roles in Biotic and Abiotic Stress Responses in Kiwifruit
Authors: Cao Yingying , Zhang Congxiao , Liu Fang , Li Dawei , Zhang Aidi , Li Li , Zhang Xiujun
Published: March 2024

Abstract: Kiwifruit, a perennial horticultural crop known for its nutritional value, faces significant challenges due to biotic and abiotic stresses, affecting its yield and quality. Leucine-rich repeat receptor-like proteins (LRR-RLPs), a major group of receptor-like proteins in plants, have diverse functions in plant physiology, including growth, development, signal transduction, and stress responses. Despite their importance, the specific roles of kiwifruit LRR-RLPs in response to biotic and abiotic stresses remain poorly understood. In this study, we investigated the expression patterns of kiwifruit LRR-RLPs under various stress conditions, including pathogen stress, heat stress, waterlogging stress, and copper stress. Through genome and transcriptome analyses, we identified a total of 101, 164, and 105 LRR-RLPs in Actinidia Chinensis 'Hongyang', Actinidia eriantha 'Huate', and Actinidia chinensis 'Red5' kiwifruit, respectively, classified into 9 subgroups based on phylogenetic relationships. Synteny analysis revealed that the expansion of kiwifruit LRR-RLPs was primarily attributed to segmental duplication events. Using RNA-seq data from pathogen-infected kiwifruits, we identified specific LRR-RLP genes potentially involved in different stages of pathogen infection. Additionally, we observed the potential involvement of kiwifruit LRR-RLPs in abiotic stress responses, with upstream transcription factors possibly regulating their expression. Furthermore, protein interaction network analysis unveiled the participation of kiwifruit LRR-RLP genes in the regulatory network of abiotic stress responses. These findings highlight the crucial roles of LRR-RLPs in mediating both biotic and abiotic stress responses in kiwifruit, offering valuable insights for the breeding of stress-resistant kiwifruit varieties.
Alternatives Cover Crops and Soil Managements Modified Macronutrients, Enzymes Activities and Soil Microbial Diversity in Rainfed Olive Orchards (cv.Chétoui) under Mediterranean Conditions in Tunisia
Authors: Fadoua ELHADDAD , Chehab Hechmi , González Julio Antonio Calero , Sifiane Abdelhamid , Roberto Garcia
Published: March 2024

In Tunisia, olive is the most cultivated fruit crop while in the north where rainfall exceeded 400mm.year-1, the olive growing area is in widely extension in marginal soil with high slope gradient. Thus, the inclusion of cover crops is a sustainable solution to increase the ecosystem productivity, improve the soil fertility and oil yields. But, in Tunisia a few study were investigated the effect of legumes cover crop on the olive productivity. Therefore, the aim of this study was to evaluate the short-term (two cropping seasons s 2021 and 2022) effects of different seeded cover crops and soil management practices on the cover crops and soil characteristics, as well as enzymes activities and related microbial diversity. Six intercropping were tested in rainfed olive orchards (cv.Chétoui): Spontaneous vegetation (Spont), Wheat, Vetch, Oat, Fenugreek, mixture Vetch-Oat and compared to control (3 periodic tillage/year without intercropping). During the first cropping season, cover crops were cut as animal feed and only residues were incorporated into the soil. While, during the second year, all cover crops biomass were incorporated into the soil. Results indicate that the dry biomass and carbon uptake were significantly higher in grasses species (Wheat and Oat). But, highest level of nitrogen was found in Fenugreek cover crops. As compared to control, all cover crops including spontaneous vegetation increased soil organic matter and macronutrient level, mainly phosphorus. The most activity of β-glucosidase, phosphatase and arysulphatase was found in the cover crops plot of wheat and oat. In addition, this study improve that the utilization of the carbon sources was dominated by amides, amine and amino-acids in the fenugreek plot; while it was dominated by polymers and carboxylic acids in the case of wheat and oat.
IDENTIFIKASI HOMESTAY DESA WISATA EDUKASI CISAAT JAWA BARAT
Authors: Salsabila Shafira , Mashabi Nurlaila Abdullah , Marsita Jaka
Published: March 2024

Penelitian ini bertujuan mengidentifikasi homestay berdasarkan Asean homestay standard untuk menggolongkan tipe homestay di Desa Wisata Edukasi Cisaat Subang Jawa Barat. Penelitian ini merupakan penelitian kuantitatif deskriptif, pengumpulan data diperoleh melalui kuesioner dan observasi. Sampel dalam penelitian ini menggunakan non probability sampling dengan tahapan metode yaitu sampling jenuh dengan jumlah sempel sebanyak 69 penyedia homestay yang rumahnya disewakan untuk wisatawan yang menginap. Hasil penelitian menunjukkan sebanyak 49 homestay sudah memenuhi Asean homestay standard berada di tingkat melampaui, sedangkan terdapat 19 homestay berada di tingkat homestay sangat baik dan 1 homestay berada di tingkat baik. Masih terdapat 20 homestay belum memenuhi Asean homestay standard perlu adanya perbaikan dalam struktur bangunan akomondasi pada homestay, dan perlu diterapkan secara komplit pelayanan hygiene and cleanliness pada homestay tersebut.
Homosexuals; What are the Contributing Factors’?
Authors: Yendi Frischa Meivilona , Anggraini Vivi , Solina Wira , Febriani Rahmi Dwi , Handayani Puji Gusri
Published: March 2024

As evidenced by the numerous gay instances that have been reported in various print and electronic media, homosexuals continue to emerge in a variety of spheres of life. By understanding the causes influencing the existence of homosexuals, researchers paid particular attention to this condition in order to intervene in gay difficulties. The purpose of this study is to outline the variables that contribute to homosexual conduct in Padang. Data on 32 homosexuals in the city of Padang were collected for this quantitative descriptive study. Utilizing the FRC Homosexuality Inventory (FHI), data were gathered. Descriptive analysis was used to examine the data. The results showed that the dominant factors cause homosexual behavior, namely spiritual values in life (9.38 percent), social engagement in the gay community (87.5 percent), and the tragic experience of being the victim of sexual assault or harassment (18.75 percent). There are some preventive actions that may be performed to stop someone from developing gay tendencies.
The Phenomenon of Hatred in Adolescents: A Systemic-Relational Study and Alternative Intervention Strategies
Authors: Septiana Nila Zaimatus , Hidayah Nur , Ramli M. , Fattah Hanurawan
Published: March 2024

The prevalence of hatred among adolescents, spanning schools, families, communities, and cyberspace, is a significant issue that requires further research, especially among Indonesian youth in the school environment. This qualitative study investigates hatred in adolescents using a systemic relational paradigm and alternative intervention strategies. Through in-depth interviews with five participants and a focus on three hate themes, it was found that all participants had experienced hatred, leading to distancing themselves from and severing connections with their haters. Some participants reported long-term trauma and feelings of anger and threat. They committed to reducing hatred and redirecting their focus to positive aspects, acknowledging the harmful effects of nurturing hatred. Relational hatred arises from family conflicts, particularly those involving parents, and social conflicts that induce trauma, emphasizing the crucial role of the family and social environment in prevention and intervention efforts. Addressing the phenomenon of hatred among adolescents is crucial to protecting both haters and those who are hated, providing an opportunity for counsellors and other supportive figures to implement suitable interventions.
The Application of Islamic Counseling to Overcome Post-Suicide Attemption in Female Adolescent with Minor Depression
Authors: Dariyo Agoes , Tumanggor Raja Oloan
Published: March 2024

Suicide is an act of recklessness to end one's life so that someone dies. The main cause of suicide is depression, a condition of psychiatric pressure characterized by disappointment, anxiety, hopelessness, loss of meaning in life and thoughts of suicide. This study aims to analyze the application of Islamic counseling to overcome post-suicide attempts in young women who experience minor depression. The research used a qualitative-descriptive approach with a focus on case studies on 3 young girls who had attempted suicide. Sampling technique with purposive sampling. Retrieval of data using interviews, observations and documentation records. Data analysis using a thematic approach. The results of the study show that the application of Islamic counseling is effective in dealing with post-suicide attempts in female adolescents who experience minor depression. In general, before attending counseling, adolescents experience depression and suicidal thoughts, but after attending counseling, adolescents feel relieved, happy, repent and return to the right path according to religious teachings. The application of Islamic counseling is able to provide positive changes from the spiritual, cognitive, affective and conative dimensions, so that the counselee has a psychological and spiritual health condition (mental health and spiritual health).
Ziadat Ṭalabat ' Īefa' Alzawaj 'Athna' Tafashiy Maraḍ Fayrus Kuruna Fi Mahkamat Buywlali Min Manẓur Alqanun Al'iislamī
Authors: Riyadi Fuad , Ngazizah Inna Fauziatal
Published: March 2024

الزواج المبكر مشكلة مجتمعية لا يمكن حلها بالشكل الصحيح. لقد أظهرت حالات الزواج المبكر في الواقع زيادة كبيرة إلى حد ما في محكمة بويولالي الدينية منذ جائحة كوفيد-19. يهدف هذا البحث إلى تحديد عملية طلب الإعفاء من الزواج في محكمة بويولالي الدينية أثناء الوباء. بصرف النظر عن ذلك، يهدف هذا البحث إلى استكشاف العوامل الدافعة لزيادة طلبات الزواج في محكمة بويولالي الدينية أثناء الوباء ودراسة الزيادة في طلبات الزواج في محكمة بويولالي الدينية أثناء الوباء من الشريعة الإسلامية و المنظور الصحي. طريقة البحث المستخدمة هي القانونية التجريبية. وأظهرت نتائج البحث أن عملية تقديم طلبات إعفاء الزواج أثناء الجائحة تتم وفق الإجراءات المعمول بها، ومن العوامل التي تحدث في الزواج المبكر العوامل الاقتصادية والتربية الاجتماعية والأسرة والتأثير السلبي للزواج المبكر، خطر الحمل الذي يؤدي إلى وفاة الطفل والأم، وخطر العنف المنزلي، وخطر الطلاق، بحيث أنه وفقا للشريعة الإسلامية، فإن الزواج المبكر ليس من تعاليم الإسلام لأنه ينتهك حقوق الأطفال في النمو. حسب أعمارهم ويميل إلى جلب الضرر بدلاً من البركات
Leveraging TikTok for Enhanced Digital Marketing and Consumer Engagement
Authors: Rahmah Eva Zulfiatur , Rangga Moch Devan , Syaro M Fandi , Rahmayanti Vivia Nailur , Cahyana Atikha Sidhi
Published: March 2024

This study explores the increasing utilization of digital platforms for marketing, focusing on the TikTok application due to its burgeoning popularity across diverse demographics. The research employs a mixed-methods approach, analyzing both quantitative usage data and qualitative consumer feedback to assess the effectiveness of online promotions through TikTok. Results demonstrate that TikTok's accessibility and widespread adoption significantly enhance product visibility and consumer engagement, leading to increased sales. Furthermore, the convenience of shopping via this platform saves time and energy for consumers, highlighting a shift in purchasing patterns. The implications of these findings suggest that businesses can leverage TikTok to tap into a broader market, potentially reshaping traditional marketing strategies and consumer interaction in the digital age.
Highlights:

Online promotions via TikTok are gaining popularity due to widespread usage and accessibility.
Shopping online saves time and energy by eliminating the need to visit physical stores.
Utilizing platforms like TikTok for marketing offers a dynamic and engaging way to reach potential customers.

Keywords: Online Shop, Utility, Dynamic System, Simulation
User guidelines on catchment hydrological modeling with soil thermal dynamics in Gridded Surface Subsurface Hydrologic Analysis (GSSHA)
Authors: Pradhan Nawa Raj , Downer Charles Wayne , Marchenko Sergey
Published: March 2024

Climate warming is expected to degrade permafrost in many regions of the world. Degradation of permafrost has the potential to affect soil thermal, hydrological, and vegetation regimes. Projections of long-term effects of climate warming on high-latitude ecosystems require a coupled representation of soil thermal state and hydrological dynamics. Such a coupled framework was developed to explicitly simulate the soil moisture effects of soil thermal conductivity and heat capacity and its effects on hydrological response. In the coupled framework, the Geophysical Institute Permafrost Laboratory (GIPL) model is coupled with the Gridded Surface Subsurface Hydrologic Analysis (GSSHA) model. The new permafrost heat transfer in GSSHA is computed with the GIPL scheme that simulates soil temperature dynamics and the depth of seasonal freezing and thawing by numerically solving a one-dimensional quasilinear heat equation with phase change. All the GIPL input and output parameters and the state variables are set up to be consistent with the GSSHA input-output format and grid distribution data input requirements. Test-case simulated results showed that freezing temperatures reduced soil storage capacity, thereby producing higher peak and lower base flow. The report details the functions and format of required input variables and cards, as a guideline, in GSSHA hydrothermal analysis of frozen soils in permafrost-active areas.
COMMUNITY PARTICIPATION IN THE FORMATION OF REGIONAL REGULATIONS IN BANGKALAN REGENCY IN THE FIELD OF TOURISM BASED ON SUSTAINABLE TOURISM
Authors: Laila Novi Eka Syarifatul , Zaman Nurus
Published: March 2024

The legal basis for community participation is regulated in chapter XI of Law Number 12 of 2011 article 96 which states that the community has the right to provide input orally/in writing in the formation of laws and regulations. The problems studied in this research are: First, how is participation the people of Bangkalan Regency in planning, compiling and discussing local regulations on halal tourism. Second, what are the legal consequences if the formation of regional regulations in the field of tourism does not involve the participation of the community. The methodology used in this research is empirical juridical research with a normative/socio legal approach. The results obtained in this study are: First, how is the participation of the people of Bangkalan Regency in the process of forming regional regulations which are considered not fully in accordance with the provisions of Law Number 12 of 2011. Second, there are no rules regarding sanctions related to non-participation community participation in the process of forming local regulations/legislation. This is because the local government has not maximized the use of third party services in the process of forming local regulations in the preparation of academic papers and/or regional regulations.
Navegando pelo conhecimento
Authors: Conceição André , Roedel Tamily
Published: March 2024

Este artigo relata uma experiência educacional que visa sensibilizar os alunos do 5º ano de uma escola pública sobre a Pesca Artesanal e Industrial, explorando impactos locais e promovendo a sensibilização para a sustentabilidade marinha. Foram adotados os princípios da cultura oceânica, por ser uma escola pertencente ao Programa Escola Azul. O trabalho teve uma abordagem qualitativa, com o uso de metodologia ativa. A pesquisa aborda uma lacuna na educação marinha, enfatizando a necessidade de integrar a sustentabilidade na educação. Na aplicação da sequência didática, foram discutidos a evolução da pesca, desde a tradição milenar até a sua utilização como ferramenta pedagógica contemporânea, mesmo diante da complexidade do tema. O projeto teve um impacto transformador, estimulando o pensamento crítico e a participação ativa dos alunos, preparando as gerações futuras para um comprometimento consciente com o ambiente em que vivem.
Deciphering Cell Types by Integrating scATAC-seq Data with Genome Sequences
Authors: Yang Yuedong , Zeng Yuansong , Luo Mai , Shangguan Ningyuan , Shi Peiyu , Feng Junxi , Xu Jin , Chen Ken , Lu Yutong , Yu Weijiang
Published: March 2024

The single cell ATAC sequencing (scATAC-seq) technology provides insight into gene regulation and epigenetic heterogeneity at single-cell resolution, but cell annotation from scATAC-seq remains challenging due to high dimensionality and extreme sparsity within the data. Existing cell annotation methods mostly focused on cell peak matrix without fully utilizing the underlying genomic sequence. Here, we propose a method, SANGO, for accurate single cell annotation by integrating genome sequences around the accessibility peaks within scATAC data. The genome sequences of peaks are encoded into low-dimensional embeddings, and then iteratively used to reconstruct the peak stats of cells through a fully-connected network. The learned weights are considered as regulatory modes to represent cells, and utilized to align the query cells and the annotated cells in the reference data through a graph transformer network for cell annotations. SANGO was demonstrated to consistently outperform competing methods on 55 paired scATAC-seq datasets across samples, platforms, and tissues. SANGO was also shown able to detect unknown tumor cells through attention edge weights learned by graph transformer. Moreover, according to the annotated cells, we found cell type-specific peaks that provide functional insights/ biological signals through expression enrichment analysis, cis-regulatory chromatin interactions analysis, and motif enrichment analysis.
The effect of green stormwater infrastructures in urban tier human thermal comfort—a case study in high-density urban blocks
Authors: Xu Haishun , Hong Yating , Lu Ziyan , Zhang Jinguang
Published: March 2024

Using green stormwater infrastructure (GSI) is the main method of greening and cooling high-density blocks. Many studies have been conducted to evaluate the effect of a single GSI on thermal comfort on sunny days. However, GSI often occurs in combinations, and assessment of GSI cannot ignore the effect of rainwater on the thermal comfort improvement. Therefore, based on measured data of a real urban area of Nanjing, China, this study used 45 GSI single and combination simulation scenarios and three local climate zone (LCZ) baseline scenarios to compare and analyze three high-density blocks in the city. The physiological equivalent temperature (PET) was calculated using the ENVI-met specification to evaluate outdoor thermal comfort. The study produced the following results. (1) To improve outdoor thermal comfort, compact high-rise and mid-rise areas require more abundant GSI combinations, but only using a single GSI can have a good effect in compact low-rise area. (2) In extreme high-temperature weather, rainfall is a necessary condition for improvement of thermal comfort by GSI, and complex GSI can extend the thermal comfort improvement time following rainfall by more than 1 hour. (3) To improve the thermal comfort of a potential area of outdoor crowd activity to the greatest extent, shading and tree setting should be added based on the premise of increasing the combinations of GSI, and the efficiency of improvement can reach as high as 54.23 %. The results of the study indicated that future GSI construction in high-density blocks should focus on different combinations of GSI based on different LCZs. This conclusion provides a reference for other regions in Southeast Asia, where GSI construction systems should be studied and formulated in accordance with different LCZs.
Behavior of Solar Cells Under 1 MeV Electrons Irradiation: Impact of Diffusion Length Reduction, Majority Carrier Removal and SCR Widening
Authors: Tchouadep Guy Serge , Soro Boubacar , Tchedre Kpéli Esso-Ehanam , Ouedraogo Ouedraogo Adama , Compaore Wendlassida Patrice , Zerbo Issa , Zoungrana Martial
Published: March 2024

When solar cells are used for space applications, there are exposed to different types of energetic particles such as protons and electrons. Those energetic particles create defects in the base of the solar cell and lead to the degradation of the performances of the solar cell. Three mainly phenomenon observed in silicon solar cells exposed to 1 MeV electron irradiation are decrease in diffusion length, removal of majority charge careers and enlargement of Space Charge Region (SCR). These three phenomenon lead to the type conversion of the base of solar cell and an anomalous behavior of the short-circuit current for a certain value of the fluences. In the present study, theoretical approach is used to investigate the impact of decrease in diffusion length, removal of majority charge careers and enlargement of SCR on the anomalous behavior of the short-circuit current and type conversion of the base. The electric parameters are studied under AM 1.5 for different fluences of 1 MeV electrons. It was found that, defects responsible for the anomalous behavior of the short-circuit current could appear for different values of the fluences and that, the type conversion of the base is caused by the removal of the majority charged carriers and decrease in diffusion length while the anomaly observed in the evolution of the short-circuit current is caused by the widening of the SCR.
Potential crucial genes associated with ferroptosis in atrial fibrillation
Authors: Li Dan , Yin Yuehui
Published: March 2024

Background
Atrial fibrillation (AFib) is one of the most prevalent arrhythmias, with significant health and socioeconomic impacts. However, the mechanisms underlying the occurrence and progression of AFib are not completely explained by previous studies, and ferroptosis in AFib have rarely been reported. This study aimed to dissect the potentially crucial genes associated with ferroptosis in AFib.
Methods
Two datasets (GSE79768 and GSE115574) related to AFib were obtained from the Gene Expression Omnibus (GEO) database, and ferroptosis-related genes were downloaded from the GeneCards database. The “limma” package in R software was used to identify the ferroptosis-related differentially expressed genes (FRDEGs). Gene ontology (GO) and gene set enrichment analysis (GSEA) were performed. Protein-protein interaction (PPI), TF-mRNA, and mRNA-miRNA regulatory networks were constructed. The interaction between FRDEGs and drugs was established using the Comparative Toxicogenomics Database (CTD). Receiver operating characteristic (ROC) curves were generated to evaluate the diagnostic validity of the biomarkers. Rats were randomly divided into AF group(n = 5) and SR group(n = 5). Rats in the AF group received daily tail vein injections of Ach (66 µg/mL)-CaCl2 (10 mg/mL) with a dose of 0.1 mL/100 g for 14 consecutive days, while those in the SR group received daily injections of the same volume of saline solution. qRT-PCR was used to detect the mRNA expression levels of ATF3 and COPG1 in the atrial tissues of both groups.
Results
A total of 14 FRDEGs of AFib were identified, which were concentrated in the biological processes (BP) (e.g., response to steroid hormone), cellular components (CC) (e.g., endocytic vesicle), and molecular functions (MF) (e.g., androgen receptor binding), affecting pathways such as the IL8 CXCR2 pathway and inflammatory response pathway. Furthermore, two biomarkers(ATF3 and COPG1) had a favorable diagnostic value in the cohort obtained after merging the GSE79768 and GSE115574 datasets. Further experiments confirmed that there are differences in the expression of ATF3 and COPG1 between the AF group and SR group SD rats.
Conclusion
The two potential key genes, ATF3 and COPG1, are associated with the ferroptosis mechanism underlying atrial fibrillation, making them potential therapeutic targets for AF.
Phytochemical Studies, GC-MS Analysis and In vivo Analgesic, Anti-inflammatory and Antidiarrheal Activity of Chaerophyllum villosum Wall. ex Dc. and Achillia millefolium L
Authors: Adil Muhammad , Dastagir Ghulam , Filimban Faten Zubair , Naseer Muhammad , Ambrin Ambrin , Quddoos Atifa , Sher Ayaz Ali
Published: March 2024

Background:
Chaerophyllum villosum (Ganjari) and Achillea millefolium L. (Yarrow) are highly medicinal plants widely used in both folk and official medicine.
Materials and Methods:
The analgesic activities of C. villosum and A. millefolium were evaluated by hot plate method and acetic acid-induced writhing test, the anti-inflammatory activities were evaluated by carrageenan-induced paw oedema method and antidiarrheal activity was carried out by charcoal meal test.
Results:
The quantitative phytochemical analysis and gas chromatography-mass spectrometry analysis of both plants showed several phytoconstituents including alkaloids, phenols, tannins, flavonoids, saponin, terpenoids with highest concentration of Tri tetracontane (7.52%) and methyl stearate (8.5%) in methanolic and chloroformic extract of C. Villosum respectively. Octadecanal (6.21%) and n-hexadecanoic acid (10.6%) were showing maximum concentration in methanolic and chloroformic extract of A. millefolium respectively. The chloroformic extract of A. millefolium showed higher (25.33 ± 4.72) peripheral analgesic activities at 300 mg/kg. The chloroformic extract of Chaerophyllum villosum exhibited higher (11.56 ± 0.15) central analgesic activities at 300 mg/kg. In antidiarrheal activity the methanolic extract of Chaerophyllum villosum highly (17.06 ± 1.5) inhibited charcoal movement at 300 mg/kg. In anti-inflammatory activities the chloroformic extract of Chaerophyllum villosum at 300 mg/kg showed high inhibition in the paw volume (1.09 ± 0.04) after 5 hours of induction of carrageenan.
Conclusion:
The results suggested that Chaerophyllum villosum and Acheilia millefolium exhibited significant peripheral and central analgesic activity, anti-inflammatory and antidiarrheal activity which elucidated its use in the treatment of pain, inflammation and gastrointestinal disorders.