bluuebunny/crossref_metadata_2025 huggingface dataset:
Fish Consumption Improved Head Circumference and Mid-Upper Arm Circumference among Infants in Zambia: A Randomised Controlled Trial
Authors: Chipili Given , Van Graan Averalda , Lombard Carl J. , Niekerk Evette Van
Published: June 2023

Fish is a good source of Animal Source Proteins (ASP). Families from low-income countries with limited access to other animal source proteins can utilize it to improve the nutrition status of infants and young children. The objective of the study was to assess if fish fed during the early complementary feeding period had an effect on improved head circumference (HC) and mid-upper arm circumference (MUAC) among infants aged 6–7 months. A randomised controlled trial was conducted from April 2019 to January 2020 in the Samfya district, Luapula Province, Zambia. The infants (238) were randomised to either the fish group (intervention) or the sorghum group (control). Every week for a period of 6 months, infants received seven sachets of fish powder and sorghum powder, respectively. Compliance was also monitored during the fish powder distribution. The head circumference measurements were conducted at baseline and once each follow-up month for a period of six months while the MUAC measurements were conducted twice (at baseline and endline). Using statistical software for data science (STATA) (version 16), a linear mixed effect model was used to analyse the data. The results showed that fish improved head circumference for age z score (HCZ) by 0.53 (95% CI: 0.23–0.82), p-value < 0.001, and MUAC by 0.36 (95% CI: 0.13–0.59) p-value < 0.002. Therefore, fish can be used as the main source of protein in complementary foods for infants and young children in low-income communities with limited access to meat.
M2 Macrophages-Derived Exosomal miRNA-23a-3p Promotes the Progression of Oral Squamous Cell Carcinoma by Targeting PTEN
Authors: Li Jun , Bao Yongjie , Peng Sisi , Jiang Chao , Zhu Luying , Zou Sihai , Xu Jie , Li Yong
Published: June 2023

Exosomes from tumor cells and immune cells regulate the tumor microenvironment through the biomolecules or microRNAs (miRNAs) they carry. This research aims to investigate the role of miRNA in exosomes derived from tumor-associated macrophages (TAMs) in the progression of oral squamous cell carcinoma (OSCC). RT-qPCR and Western blotting assays were used to determine the expression of genes and proteins in OSCC cells. CCK-8, Scratch assay and invasion-related proteins were utilized to detect the malignant progression of tumor cells. High-throughput sequencing predicted differentially expressed miRNAs in exosomes secreted by M0 and M2 macrophages. Compared with exosomes from M0 macrophages, exosomes from M2 macrophages led to enhanced proliferation and invasion of OSCC cells and inhibited their apoptosis. High-throughput sequencing results show that miR-23a-3p is differentially expressed in exosomes from M0 and M2 macrophages. MiRNA target gene database predicts that phosphatase and tensin homolog (PTEN) are target genes of miR-23a-3p. Further studies revealed that transfection of miR-23a-3p mimics inhibited PTEN expression in vivo and in vitro and promoted the malignant progression of OSCC cells, which was reversed by miR-23a-3p inhibitors. MiR-23a-3p in exosomes derived from M2 macrophages promotes malignant progression of OSCC. PTEN is a potential intracellular target of miR-23a-3p. MiR-23a-3p, an M2 macrophage-associated exosome, is a promising target for the future treatment of OSCC.
A Phenomenological Study of Chromium Impurity Effects on Lattice Microstrains of SnO2 Nanoparticles Prepared Using Sol–Gel Technique
Authors: Motevalizadeh Leili , Tahani Masoud
Published: June 2023

In this study, the effect of chromium impurities on the crystal structure and lattice microstrains of tin oxide nanoparticles was investigated. Pure SnO2 nanoparticles were synthesized and subjected to calcination at different temperatures. Additionally, various concentrations (5%, 8%, 10% and 15%) of Cr-doped SnO2 nanoparticles were prepared using the sol–gel technique and subsequently calcined at 550 °C. Transmission electron microscopy (TEM) and X-ray diffraction (XRD) techniques were utilized to examine the structure and morphology of the doped nanoparticles. The XRD patterns of tin oxide nanoparticles with different percentages of chromium impurities showed a tetragonal structure without any additional phase. The TEM images of pure SnO2 nanoparticles showed a uniform distribution of size and shape, with relatively smaller sizes compared to Cr-doped nanoparticles. To investigate the peak broadening of Cr-doped SnO2 nanoparticles, the Halder–Wagner method and Williamson–Hall models were employed to examine the effects of crystallite sizes and lattice strain. The results showed that increasing the impurity has a dual effect on nanoparticle sizes. Increasing the chromium impurity up to 8% led to an increase in compressive stress caused by the substitution of Sn ions with Cr ions on the crystal structure of rutile, resulting in an increase in the magnitude of lattice strain. However, when the chromium impurity was increased up to 15%, interstitial doping was preferred over substitutional doping. The compressive stress was subsequently converted to tensile stress, requiring the system to spend some of its energy to overcome the compressive stress, with the remaining energy reflected in the form of tensile stress. Furthermore, Fourier transform infrared (FTIR) spectra were obtained for all of the samples, confirming the XRD analyses.
Scarabaeoidea (Coleoptera) Fauna of the Republic of Mordovia (Russia)
Authors: Egorov Leonid V. , Ruchin Alexander B. , Alekseev Sergei K. , Lukiyanov Sergei V. , Lobachev Evgeniy A. , Esin Mikhail N. , Artaev Oleg N. , Semishin Gennadiy B.
Published: June 2023

(1) Background: Beetles in the superfamily Scarabaeoidea are one of the most important groups of Coleoptera. They are found in various ecosystems all over the world and belong to coprophagous, necrophagous, saproxylophagous, phyllophagous and rhizophagous types. The aim of the study is to describe the fauna and distribution of Scarabaeoidea in the Republic of Mordovia (central part of European Russia); (2) Methods: The study was conducted from 2003 to 2023. Collection material (specimens from 1972 and 1986) was also used. Specimens were collected using traditional Coleoptera collecting methods (manual collecting, light trap, collection of rotten remains and pitfall traps). For each observation, the coordinates, number of specimens and dates were recorded; (3) Results: The dataset contains 3198 occurrences. We examined 11,011 specimens of Scarabaeoidea. The dataset contains information on 88 species of Scarabaeoidea. Of these, five species (Aphodius pedellus, Nobius serotinus, Phaeaphodius rectus, Planolinus fasciatus and Onthophagus medius) are listed for the region for the first time. Another seven species are additionally known from others taken from the literature (but were not found during the present field survey); (4) Conclusions: Species diversity of Scarabaeoidea of Mordovia accounts for 95 species from 4 families (Geotrupidae, Trogidae, Lucanidae and Scarabaeidae). Ten species (Protaetia marmorata, Anoplotrupes stercorosus, Cetonia aurata, Protaetia cuprea volhyniensis, Oxythyrea funesta, Platycerus caraboides, Serica brunnea, Melolontha hippocastani, Trichius fasciatus and Protaetia fieberi) constitute the main population of Scarabaeoidea fauna given in the dataset. The species diversity of Scarabaeoidea of the Republic of Mordovia is roughly similar in number of species to that of neighboring or more northern regions.
Understanding the Ecosystem Carrying Capacity for Romanichthys valsanicola, a Critically Endangered Freshwater Fish Endemic to Romania, with Considerations upon Trophic Offer and Behavioral Density
Authors: Burlacu Laurenţiu , Deak Gyorgy , Boboc Mădălina , Raischi Marius , Holban Elena , Sadîca Isabela , Jawdhari Abdulhusein
Published: June 2023

The most recent assessment (2008) of the IUCN Red List of Threatened Species classified Romanichthys valsanicola as critically endangered (CR). In December 2022, an expert team from the National Institute for Research and Development in Environmental Protection Bucharest investigated the presence of the species in historical locations and in other potential sites. The authors correlated public data to the actual habitat area to calculate the potential species density in relation to the specific territorial behavior. The ecological carrying capacity was represented by the consensus between the behavioral density limitations and the trophic limitations of the actual species potential habitat. Both trophic availability and populational density present encouragingly high values for the sculpin perch in the Valsan River, indicating that the natural habitat could host a considerably higher number of individuals.
Heterogeneous Flight Management System (FMS) Design for Unmanned Aerial Vehicles (UAVs): Current Stages, Challenges, and Opportunities
Authors: Wang Gelin , Gu Chunyang , Li Jing , Wang Jiqiang , Chen Xinmin , Zhang He
Published: June 2023

In the Machine Learning (ML) era, faced with challenges, including exponential multi-sensor data, an increasing number of actuators, and data-intensive algorithms, the development of Unmanned Aerial Vehicles (UAVs) is standing on a new footing. In particular, the Flight Management System (FMS) plays an essential role in UAV design. However, the trade-offs between performance and SWaP-C (Size, Weight, Power, and Cost) and reliability–efficiency are challenging to determine for such a complex system. To address these issues, the identification of a successful approach to managing heterogeneity emerges as the critical question to be answered. This paper investigates Heterogeneous Computing (HC) integration in FMS in the UAV domain from academia to industry. The overview of cross-layer FMS design is firstly described from top–down in the abstraction layer to left–right in the figurative layer. In addition, the HC advantages from Light-ML, accelerated Federated Learning (FL), and hardware accelerators are highlighted. Accordingly, three distinct research focuses detailed with visual-guided landing, intelligent Fault Diagnosis and Detection (FDD), and controller-embeddable Power Electronics (PE) to distinctly illustrate advancements of the next-generation FMS design from sensing, and computing, to driving. Finally, recommendations for future research and opportunities are discussed. In summary, this article draws a road map that considers the heterogeneous advantages to conducting the Flight-Management-as-a-Service (FMaaS) platform for UAVs.
Outdoor Thermal Comfort Optimization in a Cold Climate to Mitigate the Level of Urban Heat Island in an Urban Area
Authors: Eslamirad Nasim , Sepúlveda Abel , De Luca Francesco , Sakari Lylykangas Kimmo , Ben Yahia Sadok
Published: June 2023

Climatic and micro-climatic phenomena such as summer heat waves and Urban Heat Island (UHI) are increasingly endangering the city’s livability and safety. The importance of urban features on the UHI effect encourages us to consider the configuration of urban elements to improve cities’ sustainability and livability. Most solutions are viable when a city redevelops and new areas are built to focus on aspects such as optimum design and the orientation of building masses and streets, which affect thermal comfort. This research looks beyond outdoor thermal comfort studies using UHI data and geoprocessing techniques in Tallinn, Estonia. This study supposes that designing urban canyons with proper orientation helps to mitigate the UHI effect by maximizing outdoor thermal comfort at the pedestrian level during hot summer days. In addition, optimizing the orientation of buildings makes it possible to create shaded and cooler areas for pedestrians, reducing surface temperature, which may create more comfortable and sustainable urban environments with lower energy demands and reduced heat-related health risks. This research aims to generate valuable insights into how urban environments can be designed and configured to improve sustainability, livability, and outdoor thermal comfort for pedestrians. According to the study results, researchers can identify the most effective interventions to achieve these objectives by leveraging UHI data and geoprocessing techniques and using CFD simulations. This evaluation is beneficial in guiding urban planners and architects in proposing mitigation solutions to enhance thermal comfort in cities and creating suitable conditions for approved thermal comfort levels. Results of the study show that in the location used for the survey, Tallinn, Estonia, the orientation of West-East offers the optimum level of comfort regarding thermal comfort and surface temperature in the urban environment.
Concave Ferrite Core for Wireless Power Transfer (WPT)
Authors: Henriques Elisa de Melo , Stegen Sascha
Published: June 2023

High-efficiency wireless power transfer (WPT) systems can present a perfect solution for fast-charging autonomous guided vehicles (AGV) to improve working hours in high-tech warehouses. Stationary charging stations reduce separation distance, improving coupling factor and power transfer efficiency. Analysis and design of the WPT system focused on maximum power at the load with a SS compensation circuit to reach high efficiency while applying the theory of power transformers design to maximize the power handleability with the physical dimensions. The proposed concept fits small AGVs. This paper proposes a unique ferrite structure for the transmitter ferromagnetic core. This novel shape introduces horizontal angular misalignment resistance due to the transmitter’s omnidirectional concave disc ferrite core combined with an E-core ferrite at the receiver side. The proposed WPT system can output 200 W at 100 kHz. A realistic 3D model has been designed into a symmetrical equivalent to reducing complexity and computational effort. The visualization of the magnetic flux distribution demonstrated that the proposed design has a better path to flow without concentrating flux in small regions, reducing heating losses.
Restrictions on Hospital Referrals from Long-Term Care Homes in Madrid and COVID-19 Mortality from March to June 2020: A Systematic Review of Studies Conducted in Spain
Authors: Zunzunegui Maria Victoria , Béland François , García López Fernando J.
Published: June 2023

In March 2020, a ministerial directive issued by the Government of the Community of Madrid (CoM) in Spain included disability-based exclusion criteria and recommendations against hospital referral of patients with respiratory conditions living in long-term care homes (LTCHs). Our objective was to assess whether the hospitalization mortality ratio (HMR) is greater than unity, as would be expected had the more severe COVID-19 cases been hospitalized. Thirteen research publications were identified in this systematic review of mortality by place of death of COVID-19-diagnosed LTCH residents in Spain. In the two CoM studies, the HMRs were 0.9 (95%CI 0.8;1.1) and 0.7 (95%CI 0.5;0.9), respectively. Outside of the CoM, in 9 out of 11 studies, the reported HMRs were between 1.7 and 5, with lower 95% CI limits over one. Evaluation of the disability-based triage of LTCH residents during March–April 2020 in public hospitals in the CoM should be conducted.
Economic Evaluation of Different Implementation Variants and Categories of the EU Biodiversity Strategy 2030 Using Forestry in Germany as a Case Study
Authors: Regelmann Cornelius , Rosenkranz Lydia , Seintsch Björn , Dieter Matthias
Published: June 2023

The EU Biodiversity Strategy 2030 (EUBDS) aims to preserve and restore biodiversity by protecting large areas in the EU. An extensive part of these protected areas will presumably be covered by forests. This study analyses the economic effects of EUBDS implementation on German forestry in two scenarios, based on different possible interpretations of the EUBDS’ key commitments, using a forest economic simulation model. A special focus is placed on the opportunity costs of coarse wood debris (CWD). Over a simulated 200-year period, a decrease in timber harvest of 13% and 44% is estimated under the respective scenario assumptions. This leads to a reduction in the silvicultural contribution margin (SCM) of on average 0.25 B EUR a−1 (14%) and 0.79 B EUR a−1 (45%). In terms of the total SCM, protected forests contribute 35% and 15% in the two scenarios. The accumulation and preservation of CWD incurs a substantial loss of utility, as 15% and 19% of annual logging is required for conservation purposes. However, the EUBDS may also provide economically tangible benefits. A rational decision would be to implement a scenario if the “net benefit” from the protected status exceeds the losses from set-aside and conservation requirements.
Soil Quality Evaluation and Dominant Factor Analysis of Economic Forest in Loess Area of Northern Shaanxi
Authors: Xiang Ting , Qiang Fangfang , Liu Guangquan , Liu Changhai , Ai Ning
Published: June 2023

Choosing economically important trees and establishing planting patterns can improve soil quality in economic forests. To clarify the soil quality status of the main economic forest land distributed in northern Shaanxi, the research object in this study was jujube and apple economic forests, and the control was grassland. By evaluating 17 soil indicators, the minimum data set (MDS) and structural equation model (SEM) were used to analyze the soil quality status and its dominant factors under different economic forests and land preparation methods. The results showed that (1) compared with grassland, the economic forest has a certain improvement and promotion in soil’s properties, mainly in the water-holding capacity and available nutrients. Compared to the undisturbed slope, the level bench had better physical and chemical properties. (2) Six indicators were identified as the minimum data set for assessing soil quality, including the soil organic carbon, saturated water content, bulk density, alkaline nitrogen, sand, and total capillary porosity. In addition, structural equation model analysis showed that the soil organic carbon, saturated water content, alkaline nitrogen, and capillary porosity were the dominant factors affecting soil quality in the study area. (3) Jujube trees exhibited the highest soil quality and the best restoration effect, followed by apple trees, while grassland had the poorest restoration effect. The soil quality of undisturbed slopes under different land preparation methods was lower than that of the level bench land preparation. The outcomes of this study are to provide data support and a theoretical basis for improving soil quality, enhancing ecological benefits, and selecting and managing economic forest species, in the study area and similar regions in the future.
A Synthesis of the Ecology and Conservation of Pseudoplatystoma Catfishes in the Neotropics
Authors: Pereira Luciana A. , Castello Leandro , Orth Donald J. , Duponchelle Fabrice , Hallerman Eric M.
Published: June 2023

Species of the genus Pseudoplatystoma, the long-whiskered catfishes, are important in commercial and recreational fisheries in South America, and some species have become key to regional aquaculture. Some species of the genus are under pressure due to overfishing and the negative impacts of dams. Six questions are asked in this review: (i) What species are in the genus, and where are they distributed? (ii) What are the life histories and ecologies of Pseudoplatystoma species? (iii) What are the patterns of somatic growth for these species? (iv) What is known about the biomass, production, and population dynamics of Pseudoplatystoma? (v) What is the geographic distribution of genetic variation within Pseudoplatystoma species? (vi) What are the threats to the conservation of these species? The taxonomy of the genus currently includes eight species, respectively, distributed over the Orinoco, Amazon, Paraná, and São Francisco basins. Pseudoplatystoma catfishes typically exhibit longitudinal migrations for reproduction and lateral migration for feeding, but these patterns may vary among populations. The size of the first maturation of these catfishes varies between 57 cm to 82 cm in total length. Five of the eight species spawn during the rising water season. Pseudoplatystoma species can grow to about 130 cm in total length and 100 Kg in weight and live until 30 years of age, depending upon the species. Biomass production and population dynamics of these catfishes have not yet been fully described. Their life-history characteristics indicate that they are periodic strategists with associated population recruitment dynamics. Population genetic patterning varies among Pseudoplatystoma species, with some degree of homing behavior and genetic differentiation among populations, indicating the need for management by applying the Management Unit and perhaps Evolutionary Significant Unit concepts. The main threats to the persistence of these catfishes are overfishing and alterations in and obstruction of river flow due to the construction of hydropower dams. After synthesizing existing information on species of the genus Pseudoplatystoma, we offer suggestions for future research to fill critical gaps in the knowledge of this group.
Pretreated Green Pea Flour as Wheat Flour Substitutes in Composite Bread Making
Authors: Moreno-Araiza Oscar , Boukid Fatma , Suo Xinying , Wang Shihao , Vittadini Elena
Published: June 2023

The present study aimed to assess the impact of substituting wheat flour with three different pretreated green pea flour at different addition levels (10–50%) on fresh bread quality during a 7-day storage period. Dough and bread enriched with conventionally milled (C), pre-cooked (P), and soaked under-pressure-steamed (N) green pea flour were evaluated for their rheological, nutritional, and technological features. Compared to wheat flour, legumes had lower viscosity but higher water absorption, development time, and lower retrogradation. Bread made with C10 and P10 showed similar specific volume, cohesiveness, and firmness to the control, whereas addition levels beyond 10% decreased specific volume and increased firmness. During storage, incorporating legume flour (10%) delayed staling. Composite bread increased proteins and fiber. C30 had the lowest rate of starch digestibility, while pre-heated flour increased starch digestibility. In conclusion, P and N can be considered valuable ingredients for making soft and stable bread.
Rheology, Texture and Swallowing Characteristics of a Texture-Modified Dysphagia Food Prepared Using Common Supplementary Materials
Authors: Wang Xin , Rong Liyuan , Shen Mingyue , Yu Qiang , Chen Yi , Li Jinwang , Xie Jianhua
Published: June 2023

A dysphagia diet is a special eating plan. The development and design of dysphagia foods should consider both swallowing safety and food nutritional qualities. In this study, the effects of four food supplements, namely vitamins, minerals, salt and sugar, on swallowing characteristics, rheological and textural properties were investigated, and a sensory evaluation of dysphagia foods made with rice starch, perilla seed oil and whey isolate protein was carried out. The results showed that all the samples belonged to foods at level 4 (pureed) in The International Dysphagia Diet Standardization Initiative (IDDSI) framework, and exhibited shear thinning behavior, which is favorable for dysphagia patients. Rheological tests showed that the viscosity of a food bolus was increased with salt and sugar (SS), while it decreased with vitamins and minerals (VM) at shear rates of 50 s−1. Both SS and VM strengthened the elastic gel system, and SS enhanced the storage modulus and loss modulus. VM increased the hardness, gumminess, chewiness and color richness, but left small residues on the spoon. SS provided better water-holding, chewiness and resilience by influencing the way molecules were connected, promoting swallowing safety. SS brought a better taste to the food bolus. Dysphagia foods with both VM and 0.5% SS had the best sensory evaluation score. This study may provide a theoretical foundation for the creation and design of new dysphagia nutritional food products.
Evaluating Biological Properties of Stingless Bee Propolis
Authors: Lim Jin Ru , Chua Lee Suan , Dawood Dawood Ali Salim
Published: June 2023

The aim of the present study was to determine the content of phenolics, flavonoids and tannins, as well as the biological functions of propolis extracts from the stingless bee (Heterotrigona itama). The raw propolis was extracted via maceration with ultrasonic pretreatment in 100% water and 20% ethanol. The yield of ethanolic propolis extracts was about 1% higher than its aqueous counterpart. The colorimetric assays showed that the ethanolic propolis extract had about two times higher phenolics (17.043 mg GAE/g) and tannins (5.411 mg GAE/g), and four times higher flavonoids (0.83 mg QE/g). The higher phenolic content had enhanced the antiradical and antibacterial capacities of the ethanolic extract. The propolis extracts significantly exhibited higher antibacterial activity against gram-positive bacteria (Staphylococcus aureus) than gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). However, aqueous extract was found to have a higher anticancer property based on the viability of lung cancer cells. No cytotoxic effect was observed on normal lung cells as the cell viability was maintained >50%, even the concentration of propolis extracts were increased up to 800 µg/mL. Different chemical compositions of propolis extract would show different bioactivities depending upon the individual applications. The high content of phenolics suggests that the propolis extract could be a natural source of bioactive ingredients for the development of innovative and functional foods.
Biosensors and Smart Analytical Systems in Food Quality and Safety: Status and Perspectives
Authors: Giussani Barbara , Riu Jordi
Published: June 2023

The primary focus of research in food production revolves around ensuring food quality and safety [...]
Unveiling the Role of Capping Groups in Naphthalene N-Capped Dehydrodipeptide Hydrogels
Authors: Vilaça Helena , Carvalho André , Castro Tarsila , Castanheira Elisabete M. S. , Hilliou Loic , Hamley Ian , Melle-Franco Manuel , Ferreira Paula M. T. , Martins José A.
Published: June 2023

Self-assembled peptide-based hydrogels are archetypical nanostructured materials with a plethora of foreseeable applications in nanomedicine and as biomaterials. N-protected di- and tri-peptides are effective minimalist (molecular) hydrogelators. Independent variation of the capping group, peptide sequence and side chain modifications allows a wide chemical space to be explored and hydrogel properties to be tuned. In this work, we report the synthesis of a focused library of dehydrodipeptides N-protected with 1-naphthoyl and 2-naphthylacetyl groups. The 2-naphthylacetyl group was extensively reported for preparation of peptide-based self-assembled hydrogels, whereas the 1-naphthaloyl group was largely overlooked, owing presumably to the lack of a methylene linker between the naphthalene aromatic ring and the peptide backbone. Interestingly, dehydrodipeptides N-capped with the 1-naphthyl moiety afford stronger gels, at lower concentrations, than the 2-naphthylacetyl-capped dehydrodipeptides. Fluorescence and circular dichroism spectroscopy showed that the self-assembly of the dehydrodipeptides is driven by intermolecular aromatic π–π stacking interactions. Molecular dynamics simulations revealed that the 1-naphthoyl group allows higher order aromatic π–π stacking of the peptide molecules than the 2-naphthylacetyl group, together with hydrogen bonding of the peptide scaffold. The nanostructure of the gel networks was studied by TEM and STEM microscopy and was found to correlate well with the elasticity of the gels. This study contributes to understanding the interplay between peptide and capping group structure on the formation of self-assembled low-molecular-weight peptide hydrogels. Moreover, the results presented here add the 1-naphthoyl group to the palette of capping groups available for the preparation of efficacious low-molecular-weight peptide-based hydrogels.
Towards Understanding Aerogels’ Efficiency for Oil Removal—A Principal Component Analysis Approach
Authors: Younes Khaled , Antar Mayssara , Chaouk Hamdi , Kharboutly Yahya , Mouhtady Omar , Obeid Emil , Gazo Hanna Eddie , Halwani Jalal , Murshid Nimer
Published: June 2023

In this study, our aim was to estimate the adsorption potential of three families of aerogels: nanocellulose (NC), chitosan (CS), and graphene (G) oxide-based aerogels. The emphasized efficiency to seek here concerns oil and organic contaminant removal. In order to achieve this goal, principal component analysis (PCA) was used as a data mining tool. PCA showed hidden patterns that were not possible to seek by the bi-dimensional conventional perspective. In fact, higher total variance was scored in this study compared with previous findings (an increase of nearly 15%). Different approaches and data pre-treatments have provided different findings for PCA. When the whole dataset was taken into consideration, PCA was able to reveal the discrepancy between nanocellulose-based aerogel from one part and chitosan-based and graphene-based aerogels from another part. In order to overcome the bias yielded by the outliers and to probably increase the degree of representativeness, a separation of individuals was adopted. This approach allowed an increase in the total variance of the PCA approach from 64.02% (for the whole dataset) to 69.42% (outliers excluded dataset) and 79.82% (outliers only dataset). This reveals the effectiveness of the followed approach and the high bias yielded from the outliers.
Formulation and Characterization of Emulgel-Based Jelly Candy: A Preliminary Study on Nutraceutical Delivery
Authors: Dhal Somali , Pal Anupam , Gramza-Michalowska Anna , Kim Doman , Mohanty Biswaranjan , Sagiri Sai S. , Pal Kunal
Published: June 2023

The development of consumer-friendly nutraceutical dosage forms is highly important for greater acceptance. In this work, such dosage forms were prepared based on structured emulsions (emulgels), where the olive oil phase was filled within the pectin-based jelly candy. The emulgel-based candies were designed as bi-modal carriers, where oil-soluble curcumin and water-soluble riboflavin were incorporated as the model nutraceuticals. Initially, emulsions were prepared by homogenizing varied concentrations (10 % to 30 % (w/w)) of olive oil in a 5 % (w/w) pectin solution that contained sucrose and citric acid. Herein, pectin acted as a structuring agent-cum-stabilizer. Physico–chemical properties of the developed formulations were thoroughly analyzed. These studies revealed that olive oil interferes with the formation of polymer networks of pectin and the crystallization properties of sugar in candies. This was confirmed by performing FTIR spectroscopy and DSC studies. In vitro disintegration studies showed an insignificant difference in the disintegration behavior of candies, although olive oil concentration was varied. Riboflavin and curcumin were then incorporated into the jelly candy formulations to analyze whether the developed formulations could deliver both hydrophilic and hydrophobic nutraceutical agents. We found that the developed jelly candy formulations were capable of delivering both types of nutraceutical agents. The outcome of the present study may open new directions for designing and developing oral nutraceutical dosage forms.
Type of Sex Education in Childhood and Adolescence: Influence on Young People’s Sexual Experimentation, Risk and Satisfaction: The Necessity of Establishing School Nursing as a Pillar
Authors: Navarro-Prado Silvia , Tovar-Gálvez María Isabel , Sánchez-Ojeda María Angustias , Luque-Vara Trinidad , Fernández-Gómez Elisabet , Martín-Salvador Adelina , Marín-Jiménez Ana Eugenia
Published: June 2023

The aim is to identify the source of sexuality education used during childhood and adolescence and to analyse whether this education influences their sexual attitudes, their ability to cope with unwanted situations they experience and their satisfaction with their sexual lives. This is a non-experimental, quantitative, ex post facto, cross-sectional study. The sample is formed of 675 young people, with 50% of the ages included being between 20 (Quartile 1) and 22 (Quartile 3) years. The data collection was done by means of an online questionnaire, including sociodemographic and Likert questions about their sex life. Fisher “Independence Contrasts”and correlations were used to see and quantify the relationship among the variables. The main source of education was pornography (29.3%) and the internet (12.4%). The source of education has a significant relationship with whether the use of contraceptives is accepted or not (p < 0.001), refusal to use contraceptives (p < 0.001), engaging in risky sexual practices (p < 0.001), facing unwanted sexual situations (p < 0.001) and dissatisfaction with their sex life (p < 0.001). It is necessary that children and adolescents have sex education in safe environments, such as in a home or school setting, and the school nurse plays a vital part in this education. This would reduce the need for adolescents and young people to use the internet and pornography as a source of education. School nurses should be the educational axis to offer children and adolescents a reliable point of information about sex education. A joint work with teachers, nurses, students and parents would contribute positively to reduce the number of risky situations young people are facing, and it would promote and improve healthy attitudes towards sex and interpersonal relationships.
Knowledge, Perceptions and Attitudes of eHealth and Health Technology among Nursing Students from Gauteng Province, South Africa
Authors: Lekalakala-Mokgele Eucebious , Lowane Mygirl P. , Mogale Ntlogeleng Mabina
Published: June 2023

The use of technology in healthcare settings was identified as a crucial priority in many countries to provide quality healthcare services. eHealth or digital health technology is found to have a positive influence on improving the efficiency and quality of healthcare services. It has been proven to provide opportunities to strengthen health systems. This study aims to assess eHealth literacy, pre-existing knowledge and the nursing students’ perceptions and attitudes towards eHealth. A quantitative, descriptive, cross-sectional survey was used in this study. The population of this study comprised 266 nursing students in the undergraduate programme of the Department of Nursing, among which 244 consented to participate in the study. A standardised and self-administered tool was utilised to collect data from nursing students across the four levels of study. Results showed that students in level four exhibit high scores of knowledge in the use of eLearning technology as compared to first-entry university nursing students. Nursing students used the internet frequently, especially to access social media and search for health and medical information for their study. Attitudes towards eHealth and technology were also found to be positive. The study recommends that digital literacy should be enhanced in the nursing education curriculum in other to further strengthen the knowledge and skills towards the use of eHealth and health technology among nursing students.
Studying COVID-19 Impacts on Culture: The Case of Public Museums in Greece
Authors: Kasiola Areti , Metaxas Theodore
Published: June 2023

During the last three years, COVID-19 has had a huge impact on both tourism and culture globally. The function of every kind of cultural activity was inhibited due to curfews in all public spaces, including museums, galleries, monuments, and archeological sites, which were forced to interrupt their operation due to the restrictions that were implemented for the protection of public health. In many cases, also in Greece, museums or archeological sites employed the use of digital systems and social media, always carefully abiding by all the security measures. This study aims to investigate the impacts of COVID-19 on public museums in Greece and to pursue possible opportunities in order to improve the museums’ extroversion through the application of new strategies based on ‘New Technologies’. This is achieved through a qualitative methodology with the use of 17 semi-structured interviews to executives of Greek public museums, in order to examine the situation through various aspects, which will reinforce the sustainability of Greece’s cultural domain and its acceptance on the cultural sector. The analysis of data revealed both positive and negative results in this form of investigation.
Research Impact Education: A Systems Perspective on Two Competing Views of Higher Education
Authors: Brauer Rene
Published: June 2023

(1) Background: This conceptual paper departs from the background of how Higher Education represents a critical component of the continuation of Western civilisation and culture. Specifically, the paper addresses the knowledge gap of what an emphasis on the outcome/impact does to pedagogy at Western universities. (2) Methods: Methodologically the paper subdivides the educational process into four discrete phases as to reflect upon whom and on what premises the pedagogy happens (teaching, research, funding, and curriculum formation). (3) Research findings: The presented argument suggests that universities can focus on educating students for its own sake or as means to an end. The current impact agenda prioritizes achieving specific goals at the expense of exploratory research, leading to a different definition of research success. This could result in only end-goal-focused individuals being successful and the curriculum being changed to align with their impact ambitions, the unintended consequence being that Higher Education stops being a genuine mechanism for education and instead becomes inadvertent indoctrination. (4) Conclusions: Only by having student benefit as the primary focus of pedagogy (process view) can the inter-generational feedback loop be safeguarded, regardless of how noble other sentiments may appear to be for related practical purposes (end-product view).
Melatonin Decreases Negative Effects of Combined Drought and High Temperature Stresses through Enhanced Antioxidant Defense System in Tomato Leaves
Authors: Annadurai Mumithra Kamatchi K. , Alagarsamy Senthil , Karuppasami Kalarani M. , Ramakrishnan Swarnapriya , Subramanian Marimuthu , Venugopal Prasad R. B. , Muthurajan Raveendran , Vellingiri Geethalakshmi , Dhashnamurthi Vijayalakshmi , Veerasamy Ravichandran , Parasuraman Boominathan , Rathinavelu Sivakumar , Maduraimuthu Djanaguiraman
Published: June 2023

In tomato (Lycopersicon esculentum L.), the effects of combined drought (D) and high temperature (HT) stress during the flowering stage had not been studied in detail. Therefore, this study was conducted with an objective of quantifying the effects of foliar spray of melatonin under individual and combined drought and HT stress. At flowering stage, D stress was imposed through withholding irrigation, while HT stress was imposed through exposing the plants to ambient temperature (AT) along with an increase of +5 °C. Under D + HT, plants were first subjected to drought followed by a + 5 °C increase in AT. The duration of individual or combined stress was ten days. At 80% available soil moisture, 100 µM melatonin was sprayed on D, HT, or D + HT treated plants. Among the stresses, D + HT stress increased the thylakoid membrane damage and decreased the photosynthetic rate and fruit yield more than D or HT stress. Foliar spray of 100 µM melatonin produced decreased thylakoid membrane damage [D: 31%, HT: 26%, and D + HT: 18%] and increased antioxidant enzyme, viz., superoxide dismutase, catalase, peroxidase, ascorbate peroxidase, and glutathione reductase, activity over stress-control plants. The photosynthetic rate [D: 24%, HT: 22%, and D + HT: 19%] and fruit yield [D: 32%, HT: 23%, and D + HT: 16%] were increased over stress-control plants. Hence, it is evident that the increased photosynthetic rate and fruit yield in D + HT and 100 µM melatonin-sprayed plants may be associated with an increased antioxidant defense system. Melatonin as a novel biostimulator has a great potential in scavenging free radicals through increased antioxidant activity, which shields the photosynthetic membrane from damage and therefore helps in stress mitigation.
Political Uncertainty and Initial Public Offerings: A Literature Review
Authors: Jhawar Purvi , Seal Jayanta Kumar
Published: June 2023

The literature on the influence of political and policy-related uncertainties on financial aspects has gained an impetus in the last two decades. This study adds to the existing literature by reviewing the impact of political uncertainty on initial public offerings (IPOs). We aim to provide a holistic overview of the past research in this domain, identify the potential research gaps, and explore them further. We performed a bibliometric analysis using VOSviewer to identify the major keywords used, the most cited papers, the authors, and the major countries where research in this domain has taken place. Our perspective on the current state of the literature has been threefold. First, considering the importance of market timing in the firm’s decision to go public, it was seen that firms had shown an unwillingness to come up with an IPO during periods of high political uncertainty. Second, political uncertainty has shown its influence in all the phases of the IPO process; however, political connections and donations mitigate this effect. Third, the research in this domain is still at a very nascent stage and is mainly restricted to China and the US. Thus, we believe that there are several areas that are yet to be explored.
P2X7 Receptor and Extracellular Vesicle Release
Authors: Golia Maria Teresa , Gabrielli Martina , Verderio Claudia
Published: June 2023

Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.
Natural Compound Boldine Lessens Myotonic Dystrophy Type 1 Phenotypes in DM1 Drosophila Models, Patient-Derived Cell Lines, and HSALR Mice
Authors: Álvarez-Abril Mari Carmen , García-Alcover Irma , Colonques-Bellmunt Jordi , Garijo Raquel , Pérez-Alonso Manuel , Artero Rubén , López-Castel Arturo
Published: June 2023

Myotonic dystrophy type 1 (DM1) is a complex rare disorder characterized by progressive muscle dysfunction, involving weakness, myotonia, and wasting, but also exhibiting additional clinical signs in multiple organs and systems. Central dysregulation, caused by an expansion of a CTG trinucleotide repeat in the DMPK gene’s 3’ UTR, has led to exploring various therapeutic approaches in recent years, a few of which are currently under clinical trial. However, no effective disease-modifying treatments are available yet. In this study, we demonstrate that treatments with boldine, a natural alkaloid identified in a large-scale Drosophila-based pharmacological screening, was able to modify disease phenotypes in several DM1 models. The most significant effects include consistent reduction in nuclear RNA foci, a dynamic molecular hallmark of the disease, and noteworthy anti-myotonic activity. These results position boldine as an attractive new candidate for therapy development in DM1.
Effects of Environmental Conditions on the Individual Architectures and Photosynthetic Performances of Three Species in Drosera
Authors: Banaś Krzysztof , Ronowski Rafał , Marciniak Paweł
Published: June 2023

The aim of this study was to determine the environmental conditions, individual architectures, and photosynthetic efficiencies of three sundew species: Drosera rotundifolia, D. anglica, and D. intermedia, found in well-preserved peatlands and sandy lake shores in NW Poland. Morphological traits and chlorophyll a fluorescence (Fv/Fm) were measured in 581 individuals of Drosera. D. anglica occupies the best-lit and warmest habitats, and also those that are the most heavily hydrated and the richest in organic matter; its rosettes are larger under conditions of higher pH, less organic matter, and less well-lit habitats. D. intermedia occupies substrates with the highest pH but the lowest conductivity, the poorest level of organic matter, and the least hydration. It is highly variable in terms of individual architecture. D. rotundifolia occupies habitats that are the most diverse, and that are often poorly lit, with the lowest pH but the highest conductivity. It is the least variable in terms of individual architecture. The value of the Fv/Fm ratio in Drosera is low (0.616 ± 0.137). The highest photosynthetic efficiency is achieved by D. rotundifolia (0.677 ± 0.111). It is significant for all substrates, indicating its high phenotypic plasticity. The other species have lower and similar Fv/Fm values (D. intermedia, 0.571 ± 0.118; D. anglica, 0.543 ± 0.154). Due to its very low photosynthetic efficiency, D. anglica avoids competition by occupying highly hydrated habitats. D. intermedia has adapted to the occupation of highly variable habitats in terms of hydration, while D. rotundifolia is primarily adapted to variable light conditions.
Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells
Authors: Chang Yao-Jen , Lin Steven , Kang Zhi-Fu , Shen Bin-Jon , Tsai Wen-Hai , Chen Wen-Ching , Lu Hsin-Pin , Su Yu-Lun , Chou Shu-Jen , Lin Shu-Yu , Lin Sheng-Wei , Huang Yin-Jung , Wang Hsin-Hui , Chang Ching-Jin
Published: June 2023

TRIM28/KAP1/TIF1β is a crucial epigenetic modifier. Genetic ablation of trim28 is embryonic lethal, although RNAi-mediated knockdown in somatic cells yields viable cells. Reduction in TRIM28 abundance at the cellular or organismal level results in polyphenism. Posttranslational modifications such as phosphorylation and sumoylation have been shown to regulate TRIM28 activity. Moreover, several lysine residues of TRIM28 are subject to acetylation, but how acetylation of TRIM28 affects its functions remains poorly understood. Here, we report that, compared with wild-type TRIM28, the acetylation-mimic mutant TRIM28-K304Q has an altered interaction with Krüppel-associated box zinc-finger proteins (KRAB-ZNFs). The TRIM28-K304Q knock-in cells were created in K562 erythroleukemia cells by CRISPR-Cas9 (Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein nuclease 9) gene editing method. Transcriptome analysis revealed that TRIM28-K304Q and TRIM28 knockout K562 cells had similar global gene expression profiles, yet the profiles differed considerably from wild-type K562 cells. The expression levels of embryonic-related globin gene and a platelet cell marker integrin-beta 3 were increased in TRIM28-K304Q mutant cells, indicating the induction of differentiation. In addition to the differentiation-related genes, many zinc-finger-proteins genes and imprinting genes were activated in TRIM28-K304Q cells; they were inhibited by wild-type TRIM28 via binding with KRAB-ZNFs. These results suggest that acetylation/deacetylation of K304 in TRIM28 constitutes a switch for regulating its interaction with KRAB-ZNFs and alters the gene regulation as demonstrated by the acetylation mimic TRIM28-K304Q.