bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation-based value stream map for manual steel fabrication workstations
Authors: Alattas Abdulaziz , Suliman Alaedin , Aghajamali Kamyab , Lei Zhen
Published: September 2022

Industrial steel fabrication encounters numerous difficulties in having efficient steel production. These difficulties are usually caused by the presence of bottlenecks that are not easily identified using traditional methods. Value Stream Map (VSM) is a lean tool that can be used to identify process inefficiencies and plan to minimize non-value-added activities. However, traditional VSM is not designed to be applied in a non-repetitive work environment especially when workers are highly involved in the process such as in manual steel fabrication processes. Therefore, the typical VSM requires modification to achieve the desired outcomes. Hence, the goal of the current study is to produce a current state VSM and integrate it with a simulation model to plan for an optimized future state. The scope of this study is limited to the fitting and welding workstations since they represent the typical manual processes in the steel fabrication industry. The outcomes of this study will provide the ability to identify waste and improvement opportunities. Also, it will allow for precise quantification of the improvement gain and time savings. Decision-makers in the steel industry will have accurate information about the processes in fabrication plants. Also, they will be able to make evidence-based decisions that will ensure reduced waste and cost for steel operations.
A systematic review of quality management of offsite construction
Authors: Botchway Seth Yeboah , Pan Wei
Published: September 2022

Offsite Construction (OSC) continues to gain popularity for faster, safer, cheaper and more sustainable construction project delivery. An improved quality performance is a chief selling point in the advocacy for the widespread adoption of OSC. Paradoxically, quality issues that arise in OSC projects can be extremely costly. However, quality management (QM) is underexplored in the growing OSC literature. This paper critically reviews the QM of OSC literature to uncover the state-of-the-art and proffer recommendations for future research. 38 articles, selected from Scopus and Web of Science, published from 2009 to 2021 and distributed across 20 journals, were selected through a systematic literature review supplemented by a snowball search. An overview of QM of OSC research is provided based on the yearly distribution of articles, country/territory of affiliation, journal sources, OSC types, project life cycle stages and technologies utilised. The findings revealed a growing interest in the sub-domain. The articles were categorised under six topics: post-production quality assessment, rework and defect management, quality risk management, process improvement, requirements management and quality performance factors. This paper also proposes future research directions based on the prevailing knowledge gaps.
Pengenalan Gejala Nasopharyngeal Cancer pada Populasi Beresiko di Lombok Utara 2021 pada saat Pandemi Covid19
Authors: Kadriyan Hamsu , Yudhanto Didit , Cahyawati Triana Dyah , Putri R Novia Andansari , Wedayani Niti
Published: September 2022

Kanker adalah salah satu penyebab dari kematian, keganasan kepala dan leher yang paling sering terjadi adalah karsinoma nasofaring. Di dunia terdapat 86,500 kasus karsinoma nasofaring dan tercatat menyebabkan 50.000 kematian. Salah satu penyebab Karsinoma nasofaring adalah terinfeksi virus Epstein- Barr, dan di China, karsinoma nasofaring merupakan penyebab kecacatan dan kematian terbanyak untuk 2 karsinoma kepala dan leher. Metode Pelaksanaan kegiatan pengabdian ini adalah dengan: memberikan pengarahan oleh paramedis di Desa Binaan Kabupaten Lombok Utara bahwa akan dilakukan pengabdian berupa edukasi dan disepakati kapan dapat dilakukan. Masyarakat Desa Binaan Kabupaten Lombok Utara dikumpulkan pada waktu yang bersamaan dengan para medis dibawah pengawasan dokter spesialis Telinga Hidung dan Tenggorokkan Kepala Leher. Pengabdian Masyarakat mengenai tanda dan gejala Nasopharyngeal cancer pada kelompok beresiko amatlah penting, agar masyarakat dapat mengetahui tanda dan gejala serta faktor – faktor penyebab Nasopharyngeal cancer. Perlu dilakukan pengabdian secara berkala dan juga pemeriksaan Telinga Hidung dan Tenggorokan pada masyarakat yang memiliki faktor risiko seperti masyarakat di Desa Binaan Gumantar yang permukimannya dekat dengan tambak dan sering mengkonsumsi ikan asin.
Human-environment dynamics in the ancient Mediterranean. Keywords of a research field
Authors: Weiberg Erika , Finné Martin
Published: September 2022

Human-environment dynamics in past societies has been a major field of research in the Mediterranean for a long time, but has grown significantly following the increase in the number and quality of palaeoclimate and palaeoenvironmental records in the last two decades. Here we sketch the outline of this field of research based on 1,531 author keywords from 280 peer-reviewed articles published in 78 different scientific journals during 2016–2021. Sourced from the Web of Science, the selected studies cover the time span from the Neolithic to the Roman period across the Mediterranean and provide a large number of entry points for the interested reader regardless of their prior knowledge and specific interests. The results make evident the breadth and interdisciplinary nature of this research and show that it is possible to approach questions of human-environment dynamics in many and diverse ways. Among other things, our overview outlines the importance of temporal and spatial scales, as well as the elusive nature of causality, and highlights that monocausal models connecting climate events and societal collapse are increasingly replaced by scenarios favouring more nuanced renditions of the sequence of events within which internal societal factors are given more room for play.
The model of SCRUM master selection using fuzzy sets
Authors: Nefedov Leonid , Fil Nataliya
Published: September 2022

Problem.  The complexity of software is constantly growing. Today a user is interested in software that is integrated into all aspects of their life. Creating a large number of diverse software applications is impossible without the formation of a software development team. Agile methodologies are used to develop most modern programs. The most common is the SCRUM methodology. Team working is managed by a SCRUM master, which is the interface between the owner and the project team. Therefore, choosing an effective SCRUM master is an urgent task. Aim The work aims to increase the efficiency of software development projects by developing the SCRUM master selection model using fuzzy sets, which will consider the individual characteristics and advantages of the SCRUM project team members. Methodology. The methods and principles of fuzzy mathematics are used. Decision-making methods in the conditions of fuzzy input data were used to develop a model for choosing a SCRUM master for a software development project. Results.  Today, there are many variants of models for software development projects. The choice of one or another option depends on the features and requirements of the project. A fuzzy model for choosing a SCRUM master for managing a software development project has been developed. An example of work distribution between performers using the theory of fuzzy sets is given. Calculations were made in Microsoft Excel. Originality. The developed model allows choosing a SCRUM master in the conditions of fuzzy information about the individual preferences of the areas of the software development project team. Practical value. Using the proposed SCRUM master selection model for a software development project will improve project team communication and reduce the development time. In addition, the proposed model can be used to select a SCRUM master for other projects.
In Vitro Bioactivities of Extracts from Tomato Pomace
Authors: Jamaleddine Aya , Caro Pascale de , Bouajila Jalloul , Evon Philippe , Haddad Juliano G. , El-Kalamouni Chaker , Hijazi Akram , Merah Othmane
Published: September 2022

Background: Tomato pomace (TP) is a coproduct generated by the extraction of tomato pulp, and is a potential source of bioactive molecules. In this study, we isolated several fractions from TP and evaluated their biological properties. Materials and Methods: TP was treated by maceration at room temperature with green solvents (ethanol, ethyl acetate, ethanol:water and ethanol:ethyl acetate) or supercritical CO2 (SC-CO2). The extracts were analyzed by HPLC-DAD to determine their composition, and their antioxidant activity was assessed. The potential therapeutic effects of the isolated fractions were assessed in vitro. Results: We identified 30 molecules on chromatography profiles, which revealed an abundance in phenolic acids, carotenoids, flavonoids and tannins, with differences in selectivity according to the solvent and pretreatment used. The highest radical scavenging activities were measured at 64–72% inhibition, corresponding to the ethanol or ethanol:water extracts with the highest polyphenol or flavonoid contents. Carotenoid content was increased by chemical pretreatment, to attain levels of 161 mg β-carotene/g ethyl acetate extract. This level of carotenoids seemed to have anti-inflammatory effects, with an IC50 of 9.3 μg/mL. In terms of anti-diabetic effects, the activities of α-glucosidase and α-amylase were best inhibited by extraction in an ethanol-to-water mixture (50:50). Cytotoxicity in a tumor cell line were highest for SC-CO2 extracts (64.5% inhibition) and for ethanol extracts obtained after the enzymatic pretreatment of TP (37% inhibition). Some extracts also had dose-dependent activity against Zika virus. Conclusions: New fractions obtained from TP with ecocompatible solvents in mild conditions are rich in bioactive molecules. A comparison of the chromatographic profiles of the extracts led to the identification of several key molecules with therapeutic properties. The chemical pretreatment of TP is justified as a mean of increasing the carotenoid content of ethyl acetate fractions, whereas enzymatic pretreatment can increase the antioxidant activity of ethyl acetate fractions and increase the cytotoxicity of ethanol fractions. The SC-CO2 fraction contained a smaller number of metabolites detectable on HPLC, but it had high levels of cytotoxicity and antioxidant activity. Finally, the fractions obtained appeared to be suitable for use to target one or several of the biological activities studied.
PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells
Authors: Feng Yan , Zhang Xu , Zhang Songfa , Xu Shanshan , Chen Xiaojing , Zhou Caiyun , Xi Yongmei , Xie Xing , Lu Weiguo
Published: September 2022

Background: Enhanced glycolysis occurs in most human cancer cells and is related to chemoresistance. However, detailed mechanisms remain vague. Methods: Using proteinomics analysis, we found that the glycolytic enzyme Phosphoglycerate mutase 1 (PGAM1) was highly expressed in the paclitaxel-resistant ovarian cancer cell line SKOV3-TR30, as compared to its parental cell line SKOV3. Cell Counting Kit-8 proliferation experiment, plasmids and siRNA transfection, pyruvic acid and lactic acid production detection, immunofluorescence staining of functional mitochondria and oxygen consumption rate and extracellular acidification rate measurement were uesd to assess the glycolytic metabolism and paclitaxel resistance in ovarian cancer cells. The expression and prognostic effect of PGAM1 in 180 ovarian cancer patients were analyzed. Results: SKOV3-TR30 cells display higher glycolytic flux and lower mitochondrial function than SKOV3 cells. Down-regulation of PGAM1 in SKOV3-TR30 cells resulted in decreased paclitaxel resistance. Up-regulation of PGAM1 in SKOV3 cells led to enhanced paclitaxel resistance. Analysis of the glycolytic flux revealed that PGAM1-mediated pyruvic acid or lactic acid production could modulate the capabilities of ovarian cancer cell resistance to paclitaxel. Our data also show high expression of PGAM1 as significantly correlated with reduced overall survival and reduced progression free survival in ovarian cancer patients. Conclusions: PGAM1 acts to promote paclitaxel resistance via pyruvic acid and/or lactate production in ovarian cancer cells. Inhibiting PGAM1 may provide a new approach to favorably alter paclitaxel resistance in ovarian cancer.
Periprocedural Myocardial Infarction following Elective Percutaneous Coronary Interventions
Authors: Landi Antonio , Montalto Claudio , Crimi Gabriele , De Servi Stefano
Published: September 2022

The prognostic relevance of periprocedural myocardial infarction (PMI) in patients with chronic coronary syndrome undergoing percutaneous coronary intervention (PCI) is still matter of debate, particularly regarding the type (cardiac troponin or creatin kinase-MB) and different thresholds of biomarkers elevation, as the importance of associated ancillary criteria of ischemia or concomitant angiographic complications. There are still uncertainties regarding the value of PMI as event which is prognostically equivalent to spontaneous myocardial infarction or if it simply represents a marker of baseline risk, atherosclerotic burden and procedural complexity. In the present review, we will present the mechanisms and predictors of PMI occurring during PCI and potential treatment strategies to reduce its occurrence. We will also overview all commonly adopted definitions of PMI, which carry different prevalence and prognostic implications in daily practice and clinical trials. Finally, we will discuss the impact of different PMI definitions on the interpretation of trials results, emphasizing the importance of adequate endpoints selection in the planning and interpretation of clinical trials.
Direct Oral Anticoagulants versus Vitamin K Antagonists for the Treatment of Left Ventricular Thrombosis: A Meta-Analysis
Authors: Li Jian , Hu Yuecheng , Wu Zhenhua
Published: September 2022

Background: Vitamin K antagonists (VKAs) have been recommended as first-line anticoagulants for patients with left ventricular thrombosis (LVT). Direct oral anticoagulants (DOACs) are used as an alternative to the standard of care in anticoagulation. The aim of this meta-analysis was to compare the efficacy and safety of VKAs and DOACs in the treatment of patients with LVT. Materials and Methods: Studies were identified by searching the PubMed, Web of Science, and Embase. The main outcomes included stroke or systemic embolism (SSE), thrombus resolution, and bleeding events. The pooled risk ratio (RR) with 95% confidence intervals (CIs) was estimated with fixed effect or random effect models. Results: Seventeen studies were included. Pooled estimate showed that DOACs had comparable efficacy in prevention of SSE (RR = 0.96, 95% CI: 0.80, 1.16; p = 0.677) and thrombus resolution as compared with VKAs (RR = 1.07, 95% CI: 0.97, 1.18; p = 0.193). DOACs significantly decreased the risk of stroke in patients with LVT (RR = 0.68, 95% CI: 0.47, 1.00; p = 0.048). However, this effect was not observed in the sensitive analysis by high-quality studies (RR = 0.69, 95% CI: 0.47, 1.02; p = 0.06). In terms of safety outcomes, DOACs had similar risk of bleeding events (RR = 1.12, 95% CI: 0.80, 1.57; p = 0.386) and clinically relevant bleeding events (RR = 0.49, 95% CI: 0.23, 1.03; p = 0.060). Meta-regression analysis demonstrated that none of the variables (study design, concomitant antiplatelet medication, duration of follow-up, primary cause of LVT, sample size, types of DOACs) had an impact on the risk of SSE, thrombus resolution and bleeding events. Subgroup analysis based on the use of antiplatelet and treatment switching revealed that there were no significant differences among patients with different treatment regimens. Conclusions: Based on the present evidence, both DOACs and VKA offered similar effective and safe outcomes in patients with LVT.
Cardiovascular Mechanisms of Exercise Intolerance in Older Patients with Heart Failure
Authors: Singam Narayana Sarma V. , Tabi Meir , Fleg Jerome L.
Published: September 2022

Exercise intolerance, measured by peak oxygen consumption (V̇O2), is a hallmark feature of heart failure (HF). The effect is compounded in the elderly HF patient by aging-associated changes such as a reduction in lean muscle mass, an increase in adiposity, and a reduction in maximal heart rate and peripheral blood flow with exercise. There is a non-linear reduction in peak V̇O2 with age that accelerates in the later decades of life. Peak V̇O2 is further reduced due to central and peripheral maladaptation from HF. Central mechanisms include impaired peak heart rate, stroke volume, contractility, increased filling pressures, and a blunted vasodilatory response. Peripheral mechanisms include endothelial dysfunction, reduced blood flow to muscles, and impaired skeletal muscle oxidative capacity. This review presents a focused update on mechanisms leading to impaired aerobic capacity in older HF patients.
Paclitaxel-Coated versus Uncoated Balloon for Femoropopliteal In-Stent Restenosis: A Systematic Review and Meta-Analysis
Authors: Li Qiwei , Wang Li , Zhu Lu , Wu Yong , Wu Limin , Liu Hanmin
Published: September 2022

Background: Several prospective controlled trials to date have assessed the safety and efficacy of paclitaxel-coated balloon angioplasty (PCBA) versus uncoated balloon angioplasty (UCBA) for femoropopliteal (FP) in-stent restenosis (ISR). Therefore, this meta-analysis of prospective controlled trials aimed to summarize the results of these trials and present reliable conclusions. Methods: We systematically searched the PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials.gov, and CNKI databases for prospective randomized controlled trials (published between January 1, 2008, and July 31, 2021; no language restrictions) comparing PCBA with UCBA in the management of FP ISR. The main endpoints were recurrent restenosis, primary patency, freedom from target lesion revascularization (TLR), clinical improvement, ankle-brachial index (ABI), and major adverse events (MAEs). We assessed the pooled data using a fixed effects model. Results: Of the 206 identified studies, seven were eligible and included in our analysis (N = 593 participants). Compared with UCBA, PCBA yielded a reduction in recurrent restenosis (odds ratio [OR], 0.22; 95% confidence interval [CI], 0.13–0.38), a better primary patency (OR, 3.59; 95% CI, 1.72–7.47), an improved likelihood of freedom from TLR (OR, 2.70; 95% CI, 1.36–5.35), greater clinical improvement (OR, 2.38; 95% CI, 1.50–3.79), and a similar mean difference in ABI (0.02; 95% CI, –0.11–0.14) and OR in MAEs (0.71; 95% CI, 0.24–2.14). Conclusions: PCBA as a treatment strategy can achieve better short-term outcomes of FP ISR management, including potent recurrent restenosis-lowering and symptom-improving capacity without increased MAEs. Therefore, it is a promising therapeutic strategy for patients with FP ISR. Systematic Review Registration: This work was registered in PROSPERO, the international prospective register of systematic reviews (number: CRD42021261574).
Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study
Authors: Tian Wende , Zhang Tai , Wang Xinyi , Zhang Jie , Ju Jianqing , Xu Hao
Published: September 2022

Background: The atherosclerotic cardiovascular disease (ASCVD) is a major killer and health care burden worldwide. Atherosclerosis, the common pathological foundation, has been associated with inflammation over the past few years. Some promising results also have emerged suggesting the role of targeting inflammation as a potential therapeutic option to reduce cardiovascular events. In light of the pathogenic role that inflammation plays in ASCVD, we propose to evaluate the worldwide research architecture for ASCVD and inflammation using bibliometric analysis. Methods: A search of the Web of Science Core Collection of Clarivate Analytics was performed for articles in the field published between 2012 and 2022. The number of publications per year has been visualized using GraphPad Prism through time. CiteSpace and VOSviewer were used to generate knowledge maps about the collaboration of countries, institutions, and authors, and to represent the landscape on ASCVD and inflammation research as well as to reveal current foci. Results: There were a total of 19,053 publications examined in this study. The most publications came from China (6232, 32.71%). Capital Med Univ was the most productive institution (410, 2.15%). Christian Weber published the greatest number of articles (75, 0.39%). PloS one was identified as the most prolific journal (706, 3.71%). Circulation was the most co-cited journal (13276, 2.81%). Keywords with the ongoing strong citation bursts were “nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome”, “intestinal microbiota”, “exosome”, “lncRNAs”, etc. Conclusions: It can be shown that ASCVD and inflammation research benefited from manuscripts that had a high impact on the scientific community. Asian, European and North American countries dominated in the field in terms of quantitative, qualitative and collaborative parameters. The NLRP3 inflammasome, gut microbiota and trimethylamine N-oxide, autophagy, lncRNAs, exosomes, and nuclear factor erythroid 2-related factor 2 were described to be hot themes in the field.
Mindspongenviron
Authors: Quý Khúc Văn
Published: September 2022

While I appreciate what economists have done in protecting nature and/or improving the environment over the last decades, I believe their efforts are insufficient to solve the issue.
Roman Law of Incorporating Legislation and Criminal Liability
Authors: Xin Zoho , Heith Farwani
Published: September 2022

Roman Law of Incorporating Legislation and Criminal Liability
Epistemic violence in psychological science. Issues of knowledge, meaning making and power: A critical historical and philosophical perspective.
Authors: Ncube Mvikeli
Published: September 2022

Adopting a critical historical and philosophical approach this paper informed by a social constructionist epistemology discuss limitations of mainstream psychological assumptions and research. It problematises the historical standpoint of Western psychology narrative that suggests the present state of the discipline upholds the truth, while the past is depicted as a tale of how this truth triumphed over ‘error’. In addition, the paper interrogates issues of (un)belonging, exclusion and decolonisation of methodologies to potentially improve disciplinary relevance in the global south. A broader aim of this paper is to strengthen a growing body of work on decolonisation and critical psychology. The specific aim is to enrich debates about decolonisation, epistemic justice and injustice building on from previous critical contributions in psychology within that raising questions about the role and relevance of critical psychology from the global south perspective. The paper argues that scientific knowledge is not inherently and necessarily rational, objective, and universal. It suggests that objectivity is rather socially constructed and claims for objectivity actually lead to epistemic violence towards othered peoples. (Held,2020). Therefore, all attempts at knowing and articulating psychological reality are grounded in a particular social, historical and political context. Arguments and debates engaged in this paper have important implications for academics across the globe. Our conference debates, lectures and papers can contribute to combined activisms to challenge and address oppressions that echo and reproduce colonial relations which replicate systems of power and exclusion. [for the wider globally south mostly]
Impossible Hypotheses and Effect Size Limits
Authors: van Tilburg Wijnand A. P. , van Tilburg Lennert J. A.
Published: September 2022

Psychological science is moving toward specification of effect sizes when formulating hypotheses, performing power-analyses, and considering the relevance of findings. This development has sparked an appreciation for the wider context in which such effect sizes are found, as the importance assigned to specific sizes may vary from situation to situation. We add to this development a crucial, but in psychology hitherto underappreciated, contingency: there are mathematical limits to the magnitudes that population effect sizes can take within the common multivariate context in which psychology is situated, and these limits can be far more restrictive than typically assumed. The implication is that some hypothesized or pre-registered effect sizes may be impossible. At the same time, these restrictions offer a way of statistically triangulating the plausible range of unknown effect sizes. We explain the reason for the existence of these limits, illustrate how to identify them, and offer recommendations and tools for improving hypothesized effect sizes by exploiting the broader multivariate context in which they are situated.
Abilities of Current Artificial Intelligence Systems to Learn Social Skills
Authors: Zhang Mingyang , Fabus Marco
Published: September 2022

In 2021, an article was published on MIT news that some researchers started to seek the possibility of machines learning social skills. According to the researchers, social learning may help robots to better cooperate with human society. Meanwhile, this also leads to questions such as whether social learning machines would cause people to lose their jobs. Yet, all these concerns wouldn’t be meaningful until a social learning machine is realized, so we shall first look at how and whether these social-learning machines may come true. Since this topic is huge and covers a variety of meanings and fields, this essay will provide several specific approaches to seek understanding of the relationship between machines and social learning.
If you presume relevance, you don’t need a bifocal lens (Commentary on Jagiello et al., 2022, BBS.)
Authors: Altinok Nazli , Tatone Denis , Király Ildikó , Heintz Christophe , Gergely Gyorgy
Published: September 2022

We argue for a relevance-guided learning mechanism to account for both innovative reproduction and faithful imitation by focusing on the role of communication in knowledge transmission. Unlike bifocal stance theory, this mechanism does not require a strict divide between instrumental and ritual-like actions, and the goals they respectively fulfill (material vs. social/ affiliative), to account for flexibility in action interpretation and reproduction.
Clinical, electrophysiological and MRI profile of Hirayama disease: A case series
Authors: Khan Javed Ahmad , Poudel Raju , Neupane Nirmal Prasad , Niraula Piyush , Bijukachhe Binod
Published: September 2022

Introduction: Hirayama disease (HD) is focal amyotrophy in young adults, and commonly involves distal upper limbs, often misdiagnosed as motor neuron disease and writer’s cramp. This often leads to delay in the diagnosis and results in disease progression. In this study, we have analyzed clinical, radiological and electrophysiological profile of patients presenting with hand wasting and weakness.
Materials and Methods: Patients presenting with insidious onset of hand wasting (January 2014 to February 2017) were evaluated clinically and electro physiologically. Cervical MRI in neutral and flexion position was done.
Results: All 16 patients were male, were less than 25 years of age, with median age of 22 years. Duration of illness was 3 months to 7 years. All patients presented with insidious onset of progressive weakness and lower motor neuron type of wasting of hands. Nine (56.25%) patients presented with right sided, five (31.25%) with left sided and another two (12.5%) presented with bilateral asymmetric weakness and wasting. None of the patients had neck pain or radicular symptoms. Twelve (75%) had cold paresis, eight (50%) had minipolymyoclonus and five (31.25%) had fasciculations. Electromyography (EMG) showed chronic denervation in the C7T1 myotomes. In MRI, localized lower cervical cord atrophy was seen in 13 (81.25%) cases. Asymmetric cord flattening was noted in 14 (87.5%) cases. Loss of dural attachment in 13 (81.25%), anterior displacement of dorsal dura on flexion in 14 (87.5%) and epidural flow voids were seen in 14 (87.5%) cases. Enhancing epidural crescent in flexion was seen in all 12/16 (75.0%) cases. Intramedullary hyper intensity was seen in 2 (12.5%) patients.
Conclusions: Clinical features of HD corroborated well with electrophysiological diagnosis of anterior horn cell disease of lower cervical cord. While dynamic contrast MRI is characteristic, routine studies have a high predictive value for diagnosis. Prompt diagnosis is important to differentiate it from other progressive conditions and to institute early therapy.
Büllöz pemfigoidli hastalarda serum ve lezyonel miRNA-1291 ekspresyonlarının karşılaştırılması
Authors: SUBAŞI GÖKŞİN Şule , ER URGANCI Buket , İMREN Işıl Göğem , AÇIKBAŞ İbrahim
Published: September 2022

Purpose: Bullous pemphigoid (BP) is an autoimmune disease increasing by age. miRNA-1291 is a microRNA that plays major role in many immune-mediated cutaneous diseases. We aimed to investigate the role of miRNA-1291 in BP by comparing its expression levels in serum and lesional skin and its correlation with other BP biomarkers (CCL17, anti-BP180, and anti-BP230).

Materials and methods: Twenty three patients with BP and 23 healthy control patients were included in the study. The miRNeasy Mini Kits was used for RNA isolation from serum and biopsy samples. Qiagen-miRCURY LNA RT Kit was used for conversion of cDNA. miRNA-1291 expression was performed by Real-Time PCR with the original primer and SYBR Green master mix. Serum CCL17, anti-BP180, and anti-BP230 levels were measured with use of ELISA. SPSS 25.0 (IBM SPSS Statistics 25 software) was used for statistical evaluation.

Results: The expression of miRNA-1291 in serum and biopsy samples were 7.02 and 4.77-fold significantly upregulated than that of control group respectively (p=0.001, p=0.007). The serum levels of anti-BP-180, anti-BP-230 and CCL17 in BP patients were significantly higher compared to control group (p=0.0049, p=0.0071, p=0.001). Anti-BP180, anti-BP230, CCL17 levels and serum miRNA-1291 expression were correlated positively in BP patients. Additionally, serum miRNA-1291 expression were correlated well with lesional miRNA-1291 expression.

Conclusion: The increase in miRNA-1291 levels in serum and lesional tissue compared to non-lesional tissue suggests that miRNA-1291 may play a role in the pathogenesis of BP. As miRNA-1291 correlates with other BP biomarkers, it may serve as an important biomarker for BP.
FINDING THE TRAJECTORYOF MOVEMENT OF A MATERIAL PARTICLE ON THE INNER SURFACE OF A VERTICAL CYLINDER AT THE SIDE SUPPLY OF MATERIAL
Authors: Pylypaka S. , Nesvidomin A.
Published: September 2022

The movement of material particles on the inner surface of the cylinder takes place in cyclones. Due to the complexity of the aerodynamics of the process, theoretical developments can not be used as a basis for calculating the design and efficiency of their operation. Because of this, a number of simplifications are allowed in the theoretical provisions, as a result of which the calculated data do not coincide with the experimental data.

The use of modern software products, which have great graphics capabilities, allows you to get new results in solving such problems in the form of high-quality graphic illustrations.

The aim of the study is to determine the motion of a material particle that enters the inner surface of a vertical cylinder with a given initial velocity.

A number of simplifications were introduced in the calculations: air resistance, the effect of particles on each other, their size, etc. were not taken into account. Accompanying Frenet and Darboux triangles were used to find the trajectory.

Differential equations of motion of a material particle on the inner surface of a vertical cylinder are compiled. The equations are solved using the MatLab system.

It is established that the velocity of particles that fall on the inner surface of the cylinder decreases to a certain value, and then begins to increase. For specific conditions (coefficient of friction and radius of the cylinder), the value of the minimum speed to which the movement of particles is slowed down is approximately the same and does not depend on the value of the initial speed. This means that there is a minimum value of the initial velocity at which the particle will not slow down when it hits the surface of the cylinder. Since particles with different coefficients of friction at the initial stage of their movement on the cylinder are poorly scattered on its surface, for the effective operation of the cyclone you need to make an inlet window of sufficient size in the vertical direction.
PROGRAM IMPLEMENTATION OF MOBILE PHYTOMONITORING WORK
Authors: LYSENKO V. P. , BOLBOT I. M. , MARTYNENKO A. I. , LENDIEL T. I. , NAKONECHNA K. V.
Published: September 2022

Software for monitoring the technological parameters in an industrial greenhouse has been developed. The algorithm implemented by this program provides reading and storing information about plant conditions and the values of technological parameters of the environment in the greenhouse. The robot sensor system includes two subsystems of motion sensors and a technical vision system for determining and accumulating information about the coordinates of the robot. The software components that were used to create the interface of the robot control system and the principles of interaction of the robot with the existing control system of technological parameters in the industrial greenhouse are given.
Coronary Artery Embolism: a Rare Cause of ST Segment Elevation Myocardial Infarction
Authors: Yuan Tao
Published: September 2022

Acute myocardial infarction (AMI) is a fatal clinical disease, and is often caused by thrombotic occlusion, secondary to coronary artery atherosclerotic plaque erosion or rupture [1]. But about 1-14% of AMI is caused by myocardial infarction with non-obstructive coronary atherosclerosis (MINOCA [2], which is characterized by evidence of myocardial infarction, normal coronary angiography or coronary artery stenosis of <50>]. The causes of MINOCA vary from person to person [4], such as coronary artery spasm [5], Stress cardiomyopathy [6], Thrombophilia [7], coronary artery embolism(CE) [8,9]. CE is a rare cause of AMI in clinical practice. We had presented a female patient who had left anterior descending artery embolism, with dilated cardiomyopathy and paroxysmal atrial flutter [10]. CE, while rare, is now recognized as an important non-atherosclerotic cause of AMI. In the past, the description of clinical features about CE was little or just case reports [8-9]. A recent study involving 1776 patients evaluated the clinical features of CE-related myocardial infarction. It is pointed out that the prevalence rate is 2.9% in the initial AMI. and atrial fibrillation is the most important cause of CE (73%). Other causes include cardiomyopathy and valvular heart disease. And proposed CE diagnostic criteria [11]. In recent years, thrombus aspiration devices have been widely used in AMI patients with angiographically confirmed thrombosis and have proved to be a viable and effective strategy for the treatment of thrombotically burdened AMI, including CE-related infarction. Moreover, histological examination of aspiration thrombus provides additional information for the diagnosis of CE. Although thrombus aspiration is an effective method for treating patients with CE, Stoel et al [12] reported that the diameter of the lumen of the aspiration catheter is small and useless for aspirating large thrombi. In addition, it is challenging to access to the distal lumen through the suction device. In fact, 42% of existing patients are treated conservatively because of distal occlusion or small vessel with a criminal lesion. The treatment of CE-related risk factors is also very important. Including atrial fibrillation, cardiomyopathy, rheumatic heart valve disease, prosthetic heart valve, patent foramen ovale, atrial septal defect, history of cardiac surgery, infective endocarditis or hypercoagulable state. The patient in this case was dilated cardiomyopathy with paroxysmal atrial flutter, both of which were high risk for CE. She had chest pain, typical changes in the ECG, coronary angiography revealed coronary embolization of the LAD. that are consistent with acute myocardial infarction. Intravascular ultrasound (IVUS) or optical coherence Tomography (OCT) is an effective method to detect the atherosclerotic plaque erosion or rupture of coronary artery. This patient was proved to be CE by IVUS. It is very important to given sufficient anticoagulant therapy to prevent CE in clinical practice.
Case Report: A Hidden Cause for Electrolyte Derangement in the ED: Gitelman Syndrome
Authors: Espinosa James
Published: September 2022

We present the case of a 32-year-old patient with a known history of Gitelman syndrome who presented with hypokalemia and hypomagnesemia. The patient was treated with supplemental potassium, magnesium and intravenous fluids in the ED. The patient required hospital admission for further electrolyte correction. An awaremess of Gitelman syndrome is important for the emergency physician. Some patients have a known history of Gitelman Syndrome. In such cases, it is imperative to be aware of what electrolyte abnormalities to expect. Some new diagnoses of GS can be made in patients presenting with hypotension, or myalgias along with hypokalemia and hypomagnesemia.
Diabetic Foot in Algeria Illustration IV – Clinical Case Report
Authors: Boudjenah Nadia
Published: September 2022

It seemed interesting to us to share this observation because it reflects our management of the diabetic patient with a wound and suffering from a severe disabling Neuropathy. Our clinical case today is a 55-year-old male. A patient with type 2 diabetes, on insulin therapy and oral anti-diabetics and being treated for high blood pressure. He came to our consultation on August 05, 2020, with an infection of the right foot, of which the starting point is the second and third toes. These ones being ischemic
Notas sobre a fortuna crítica acadêmica de Miguel Jorge em Goiás
Authors: Holanda George Ivan , David Nismária Alves
Published: September 2022

Este artigo apresenta uma investigação sobre a presença das obras de Miguel Jorge nos periódicos científicos e bancos digitais de teses e dissertações no estado de Goiás. Para tanto, foi feito um levantamento bibliográfico em catorze revistas e três bibliotecas digitais de Universidades goianas, encontrando-se um total de 03 artigos e 11 dissertações que discutiram as obras do referido autor. Dada a sua relevante contribuição para a literatura brasileira, conclui-se que a presença deste escritor na produção científica do estado de Goiás ainda merece mais atenção. Destacamos, por fim, que os períodicos científicos e os programas de pós-graduação podem contribuir efetivamente para a ampliação do debate e o reconhecimento da produção literária local.
Microsurgical anatomy of the auditory radiations: revealing the enigmatic acoustic pathway from a surgical viewpoint
Authors: Esen Aydin Aysegul , Aydin Seckin , Bilgin Berra , Mirkhasilova Muyassar , Bayramli Nicat , Tanriover Necmettin
Published: September 2022

OBJECTIVE

The thalamocortical projections of the auditory system have not been detailed via microanatomical fiber dissections from a surgical viewpoint. The aim of this study was to delineate the course of the auditory radiations (ARs) from the medial geniculate body to their final destination in the auditory cortex. The authors’ additional purpose was to display the relevant neural structures in relation to their course en route to Heschl’s gyrus.

METHODS

White matter fibers were dissected layer by layer in a lateral-to-medial, inferolateral-to-superomedial, and inferior-to-superior fashion.

RESULTS

The origin of ARs just distal to the medial geniculate body was revealed following the removal of the parahippocampal gyrus, cingulum bundle, and mesial temporal structures, in addition to the lateral geniculate body. Removing the fimbria, stria terminalis, and the tail of the caudate nucleus along the roof of the temporal horn in an inferior-to-superior direction exposed the lateral compartment of the sublenticular segment of the internal capsule as the predominant obstacle that prevents access to the ARs. The ARs were initially obscured by the inferolaterally located temporopulvinar tract of Arnold, and their initial course passed posterolateral to the temporopontine fascicle of Türck. The ARs subsequently traversed above the temporopulvinar fibers in a perpendicular manner and coursed in between the optic radiations at the sensory intersection region deep to the inferior limiting sulcus of insula. The distal part of the ARs intermingled with the fibers of the anterior commissure and inferior fronto-occipital fasciculus during its ascent toward Heschl’s gyrus. The ARs finally projected to a large area over the superior temporal gyrus, extending well beyond the anteroposterior boundaries of the transverse temporal gyri.

CONCLUSIONS

The ARs can be appreciated as a distinct fiber bundle ascending between the fibers of the sublenticular segment of the internal capsule and traversing superiorly along the roof of the temporal horn by spanning between the optic radiations. Our novel findings suggest potential disruption of the ARs’ integrity during transsylvian and transtemporal approaches along the roof of the temporal horn toward the mesial temporal lobe. The detailed 3D understanding of the ARs’ relations and awareness of their course may prove helpful to secure surgical interventions to the region.
Postoperative surveillance in cranial and spinal tumor neurosurgery: when is this warranted?
Authors: Schipmann Stephanie , Spille Dorothee Cäcilia , Gallus Marco , Lohmann Sebastian , Schwake Michael , Warneke Nils , Suero Molina Eric , Stummer Walter , Holling Markus
Published: September 2022

OBJECTIVE

The outbreak of COVID-19 and the sudden increase in the number of patients requiring mechanical ventilation significantly affected the management of neurooncological patients. Hospitals were forced to reallocate already scarce human resources to maximize intensive care unit (ICU) capacities, resulting in a significant postponement of elective procedures for patients with brain and spinal tumors, who traditionally require elective postoperative surveillance on ICU or intermediate care wards. This study aimed to characterize those patients in whom postoperative monitoring is required by analyzing early postoperative complications and associated risk factors.

METHODS

All patients included in the analysis experienced benign or malignant cerebral or intradural tumors and underwent surgery between September 2017 and May 2019 at University Hospital Münster, Germany. Patient data were generated from a semiautomatic, prospectively designed database. The occurrence of adverse events within 24 hours and 30 days postoperatively—including unplanned reoperation, postoperative hemorrhage, CSF leakage, and pulmonary embolism—was chosen as the primary outcome measure. Furthermore, reasons and risk factors that led to a prolonged stay on the ICU were investigated. By performing multivariable logistic regression modeling, a risk score for early postoperative adverse events was calculated by assigning points based on beta coefficients.

RESULTS

Eight hundred eleven patients were included in the study. Eleven patients (1.4%) had an early adverse event within 24 hours, which was either an unplanned reoperation (0.9%, n = 7) or a pulmonary embolism (0.5%, n = 4) within 24 hours. To predict the incidence of early postoperative complications, a score was developed including the number of secondary diagnoses, BMI, and incision closure time, termed the SOS score. According to this score, 0.3% of the patients were at low risk, 2.5% at intermediate risk, and 12% at high risk (p < 0.001).

CONCLUSIONS

Postoperative surveillance in cranial and spinal tumor neurosurgery might only be required in a distinct patient collective. In this study, the authors present a new score allowing efficient prediction of the likelihood of early adverse events in patients undergoing neurooncological procedures, thus helping to stratify the necessity for ICU or intermediate care unit beds. Nevertheless, validation of the score in a multicenter prospective setting is needed.
Późnostarożytne apele o rozpoznanie godności ludzkiej: Bazyli z Cezarei Kapadockiej, Ambroży z Mediolanu, Leon Wielki, Anonim z Werony
Authors: Guerrero van der Meijden Jadwiga
Published: September 2022

Artykuł omawia późnostarożytne chrześcijańskie apele o uznanie godności ludzkiej sformułowane przez Bazylego z Cezarei, Ambrożego z Mediolanu, Leona Wielkiego i anonimowego Mistrza z Werony. Analiza podzielona jest na części odnoszące się do każdego z wymienionych autorów, a kończy ją sekcja poświęcona, po pierwsze, wzajemnym powiązaniom między przedstawionymi tekstami i hipotezie o wzorowaniu się Leona tekstami Bazylego i Ambrożego, a po drugie, wpływom tychże apeli na myśl późniejszych wieków. Badanie wskazuje biblijne, starogreckie i rzymskie źródła chrześcijańskich wezwań. Twierdzę, że sformułowanie Leona jest pośrednio inspirowane delficką formułą gnothi seauton, która została przez chrześcijańskich myślicieli doprecyzowana do statusu aksjologicznego człowieka i uzupełniona wyrażeniami biblijnymi.
Del conocimiento tradicional ambiental al conocimiento tradicional del paisaje. El papel de la lengua local
Authors: Hernández López Israel , Bocco Gerardo , Urquijo Torres Pedro S. , Orozco Ramírez Quetzalcóatl
Published: September 2022

Los trabajos sobre conocimiento tradicional del paisaje son relativamente menos numerosos en comparación con el resto de los estudios sobre conocimiento tradicional ambiental. Esto puede corroborarse por la cantidad de publicaciones e incluso la existencia de sociedades científicas en temas relacionados con la etnobiología y la etnoecología. De manera adicional, la dimensión lingüística en los estudios relativos al conocimiento tradicional del paisaje ha sido relativamente poco estudiada en comparación con aspectos prácticos, tales como la aptitud ambiental local y el manejo agrícola. Así, el objetivo de este artículo fue esclarecer la importancia de la lengua local en los estudios sobre conocimiento tradicional del paisaje. Realizamos una revisión bibliográfica utilizando buscadores y bases de datos convencionales con el objeto de establecer los alcances y limitaciones del conocimiento tradicional o indígena sobre el paisaje, en el marco del conocimiento tradicional ambiental. Luego analizamos el papel de la lengua en los trabajos sobre conocimiento tradicional del paisaje a partir de la experiencia de campo y académica del primer autor, cuya lengua materna es el chinanteco. Enseguida indicamos las particularidades relacionadas con la dimensión lingüística inmersas en el conocimiento tradicional del paisaje, incluyendo una breve descripción de un estudio en la región de la Chinantla, Oaxaca. Finalmente concluimos con un balance en torno a los problemas relacionados con el uso de la lengua local en los estudios sobre conocimiento tradicional del paisaje.
Interaction-Oriented Software Engineering: Programming abstractions for autonomy and decentralization
Authors: Chopra Amit K.
Published: September 2022

We review the main ideas and elements of Interaction-Oriented Software Engineering (IOSE), a program of research that we have pursued for the last two decades, a span of time in which it has grown from philosophy to practical programming abstractions. What distinguishes IOSE from any other program of research is its emphasis on supporting autonomy by modeling the meaning of communication and using that as the basis for engineering decentralized sociotechnical systems. Meaning sounds esoteric but is the basis for practical decision making and a holy grail for the field of distributed systems. We describe our contributions so far, directions for research, and the potential for broad impact on computing.