bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypoxic Signaling in Skeletal Muscle Maintenance and Regeneration: A Systematic Review
Authors: Pircher Tamara , Wackerhage Henning , Aszodi Attila , Kammerlander Christian , Böcker Wolfgang , Saller Maximilian Michael
Published: June 2021

In skeletal muscle tissue, oxygen (O2) plays a pivotal role in both metabolism and the regulation of several intercellular pathways, which can modify proliferation, differentiation and survival of cells within the myogenic lineage. The concentration of oxygen in muscle tissue is reduced during embryogenesis and pathological conditions. Myogenic progenitor cells, namely satellite cells, are necessary for muscular regeneration in adults and are localized in a hypoxic microenvironment under the basal lamina, suggesting that the O2 level could affect their function. This review presents the effects of reduced oxygen levels (hypoxia) on satellite cell survival, myoblast regeneration and differentiation in vertebrates. Further investigations and understanding of the pathways involved in adult muscle regeneration during hypoxic conditions are maybe clinically relevant to seek for novel drug treatments for patients with severe muscle damage. We especially outlined the effect of hypoxia-inducible factor 1-alpha (HIF1A), the most studied transcriptional regulator of cellular and developmental response to hypoxia, whose investigation has recently been awarded with the Nobel price.
Contrasting Phylogeographic Patterns in Lumnitzera Mangroves Across the Indo-West Pacific
Authors: Guo Wuxia , Banerjee Achyut Kumar , Wu Haidan , Ng Wei Lun , Feng Hui , Qiao Sitan , Liu Ying , Huang Yelin
Published: June 2021

Mangroves are ecologically important forest communities in tropical and subtropical coasts, the effective management of which requires understanding of their phylogeographic patterns. However, these patterns often vary among different species, even among ecologically similar taxa or congeneric species. Here, we investigated the levels and patterns of genetic variation within Lumnitzera consisting of two species (L. racemosa and L. littorea) with nearly sympatric ranges across the Indo-West Pacific (IWP) region by sequencing three chloroplast DNA regions (for both species) and genotyping 11 nuclear microsatellite loci (for L. littorea). Consistent with findings in studies on other mangrove species, we found that both L. racemosa and L. littorea showed relatively high genetic variation among populations but low genetic variation within populations. Haplotype network and genetic clustering analyses indicated two well-differentiated clades in both L. racemosa and L. littorea. The relationship between geographic and genetic distances and divergence time estimates of the haplotypes indicated that limited dispersal ability of the propagules, emergence of land barriers during ancient sea-level changes, and contemporary oceanic circulation pattern in the IWP influenced the current population structure of the two species. However, the position of genetic break was found to vary between the two species: in L. racemosa, strong divergence was observed between populations from the Indian Ocean and the Pacific Ocean possibly due to land barrier effect of the Malay Peninsula; in L. littorea, the phylogeographic pattern was created by a more eastward genetic break along the biogeographic barrier identified as the Huxley’s line. Overall, our findings strongly supported previous hypothesis of mangrove species divergence and revealed that the two Lumnitzera species have different phylogeographic patterns despite their close genetic relationship and similar current geographic distribution. The findings also provided references for the management of Lumnitzera mangroves, especially for the threatened L. littorea.
Multi-Species Genomics-Enabled Selection for Improving Agroecosystems Across Space and Time
Authors: Wolfe Marnin D. , Jannink Jean-Luc , Kantar Michael B. , Santantonio Nicholas
Published: June 2021

Plant breeding has been central to global increases in crop yields. Breeding deserves praise for helping to establish better food security, but also shares the responsibility of unintended consequences. Much work has been done describing alternative agricultural systems that seek to alleviate these externalities, however, breeding methods and breeding programs have largely not focused on these systems. Here we explore breeding and selection strategies that better align with these more diverse spatial and temporal agricultural systems.
MicroRNA-Mediated Responses to Chromium Stress Provide Insight Into Tolerance Characteristics of Miscanthus sinensis
Authors: Nie Gang , Liao Zongchao , Zhong Minyi , Zhou Jie , Cai Jiabang , Liu Aiyu , Wang Xia , Zhang Xinquan
Published: June 2021

Chromium (Cr) is a heavy metal in nature, which poses a potential risk to toxicity to both animals and plants when releasing into the environment. However, the regulation of microRNA (miRNA)-mediated response to heavy metal Cr has not been studied inMiscanthus sinensis. In this study, based on high-throughput miRNA sequencing, a total of 104 conserved miRNAs and 158 nonconserved miRNAs were identified. Among them, there were 45 differentially expressed miRNAs in roots and 13 differentially expressed miRNAs in leaves. The hierarchical clustering analysis showed that these miRNAs were preferentially expressed in a certain tissue. There were 833 differentially expressed target genes of 45 miRNAs in roots and 280 differentially expressed target genes of 13 miRNA in leaves. After expression trend analysis, five significantly enriched modules were obtained in roots, and three significantly enriched trend blocks in leaves. Based on the candidate gene annotation and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) function analysis, miR167a, novel_miR15, and novel_miR22 and their targets were potentially involved in Cr transportation and chelation. Besides, miR156a, miR164, miR396d, and novel_miR155 were identified as participating in the physiological and biochemical metabolisms and the detoxification of Cr of plants. The results demonstrated the critical role of miRNA-mediated responses to Cr treatment inM. sinensis, which involves ion uptake, transport, accumulation, and tolerance characteristics.
RNA Viral Vectors for Accelerating Plant Synthetic Biology
Authors: Khakhar Arjun , Voytas Daniel F.
Published: June 2021

The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants. However, their effective utilization typically requires transgenesis, which is plagued by long timescales and high costs. In this review we explore how transgenesis can be minimized by delivering foreign genetic material to plants with systemically mobile and persistent vectors based on RNA viruses. We examine the progress that has been made thus far and highlight the hurdles that need to be overcome and some potential strategies to do so. We conclude with a discussion of biocontainment mechanisms to ensure these vectors can be used safely as well as how these vectors might expand the accessibility of plant synthetic biology techniques. RNA vectors stand poised to revolutionize plant synthetic biology by making genetic manipulation of plants cheaper and easier to deploy, as well as by accelerating experimental timescales from years to weeks.
E183K Mutation in Chalcone Synthase C2 Causes Protein Aggregation and Maize Colorless
Authors: Dong Haixiao , Li He , Xue Yingjie , Su Shengzhong , Li Shipeng , Shan Xiaohui , Liu Hongkui , Jiang Nan , Wu Xuyang , Zhang Zhiwu , Yuan Yaping
Published: June 2021

Flavonoids give plants their rich colors and play roles in a number of physiological processes. In this study, we identified a novel colorless maize mutant showing reduced pigmentation throughout the whole life cycle by EMS mutagenesis. E183K mutation in maize chalcone synthase C2 (ZmC2) was mapped using MutMap strategy as the causal for colorless, which was further validated by transformation in Arabidopsis. We evaluated transcriptomic and metabolic changes in maize first sheaths caused by the mutation. The downstream biosynthesis was blocked while very few genes changed their expression pattern. ZmC2-E183 site is highly conserved in chalcone synthase among Plantae kingdom and within species’ different varieties. Through prokaryotic expression, transient expression in maize leaf protoplasts and stable expression in Arabidopsis, we observed that E183K and other mutations on E183 could cause almost complete protein aggregation of chalcone synthase. Our findings will benefit the characterization of flavonoid biosynthesis and contribute to the body of knowledge on protein aggregation in plants.
Organic Waste-Based Fertilizer in Hydroponics Increases Tomato Fruit Size but Reduces Fruit Quality
Authors: Kechasov Dmitry , Verheul Michel J. , Paponov Martina , Panosyan Anush , Paponov Ivan A.
Published: June 2021

In regions with intensive agricultural production, large amounts of organic waste are produced by livestock animals. Liquid digestate from manure-based biogas production could potentially serve as fertilizer if integrated with closed horticultural irrigation systems. The aim of this experiment was to investigate how fertilizer based on liquid biogas by-products of pig manure digestion can affect the growth and production of tomato plants. Integration of a nitrification bioreactor presumes a significantly lower concentration of nutrient solutions and a higher level of oxygenation than classical mineral cultivation. Therefore, additional controls were included. We compared plant growth and fruit quality traits of tomato plants grown in a hydroponic solution with organic fertilizer with two levels of mineral fertilizer. The tomatoes grown with organic waste-based liquid fertilizer showed reduced growth rates but increased mean fruit size, resulting in no significant change in total yield compared with high-mineral cultivation. The growth rate was similarly reduced in plants cultivated with low-mineral fertilizer. Plants cultivated with organic waste-based fertilizer had high Cl− concentration in xylem sap, leaves, and, ultimately, fruits. The leaves of plants cultivated with organic waste-based fertilizer contained higher concentrations of starch and soluble carbohydrate and low concentrations of phosphorous (P) and sulfur (S). The plants grown with organic waste-based or low-mineral medium showed significantly poorer fruit quality than the plants cultivated with the high-mineral solution. The low-mineral treatment increased xylem sap contribution to fruit weight because of higher root power. The organic waste-based fertilization did not change the root power but increased fruit size. In conclusion, organic waste-based cultivation is a possible solution for sustainable plant production in greenhouses. However, additional adjustment of nutrient supply is required to improve fruit quality.
Development of Sequence-Tagged Site Marker Set for Identification of J, JS, and St Sub-genomes of Thinopyrum intermedium in Wheat Background
Authors: Qiao Linyi , Liu Shujuan , Li Jianbo , Li Shijiao , Yu Zhihui , Liu Cheng , Li Xin , Liu Jing , Ren Yongkang , Zhang Peng , Zhang Xiaojun , Yang Zujun , Chang Zhijian
Published: June 2021

Thinopyrum intermedium (2n = 6x = 42, JJJSJSStSt) is one of the important resources for the wheat improvement. So far, a few Th. intermedium (Thi)-specific molecular markers have been reported, but the number is far from enough to meet the need of identifying alien fragments in wheat-Th. intermedium hybrids. In this study, 5,877,409 contigs were assembled using the Th. intermedium genotyping-by-sequencing (GBS) data. We obtained 5,452 non-redundant contigs containing mapped Thi-GBS markers with less than 20% similarity to the wheat genome and developed 2,019 sequence-tagged site (STS) molecular markers. Among the markers designed, 745 Thi-specific markers with amplification products in Th. intermedium but not in eight wheat landraces were further selected. The distribution of these markers in different homologous groups of Th. intermedium varied from 47 (7/12/28 on 6J/6St/6JS) to 183 (54/62/67 on 7J/7St/7JS). Furthermore, the effectiveness of these Thi-specific markers was verified using wheat-Th. intermedium partial amphidiploids, addition lines, substitution lines, and translocation lines. Markers developed in this study provide a convenient, rapid, reliable, and economical method for identifying Th. intermedium chromosomes in wheat. In addition, this set of Thi-specific markers can also be used to estimate genetic and physical locations of Th. intermedium chromatin in the introgression lines, thus providing valuable information for follow-up studies such as alien gene mining.
Assessment of Climate Change Impacts on Chilling and Forcing for the Main Fresh Fruit Regions in Portugal
Authors: Fraga Helder , Santos João A.
Published: June 2021

Air temperature plays a major role in the growth cycle of fruit trees. Chilling and forcing are two of the main mechanisms that drive temperate fruit development, namely dormancy and active plant development. Given the strong sensitivity of these crops to air temperature and the foreseeable warming under future climates, it becomes imperative to analyze climate change impacts for fruit trees. The fruit sector in Portugal has risen significantly over the last decades, gaining increasing importance both internally and through exports. The present research assesses the impacts of climate change on the chilling and forcing for economically relevant fruit trees in Portugal, namely apples, oranges, pears, and plums. To assess temperate fruit chilling and forcing conditions, the chilling portions (CP) and growing degree-hours (GDH) were computed over Portugal, for the recent-past (1989–2005) and future (2021–2080) periods, following two anthropogenic radiative forcing scenarios (RCP4.5 and RCP8.5). Future climate data were obtained from four regional-global climate model pairs to account for model uncertainties. Bias-correction methodologies were also applied. A spatial analysis over the main regions with PDO “Protected Denomination of Origin” or PDI “Protected Geographical Indication” of origin of each fruit tree was performed. Future projections show a clear decrease in chilling for all regions and fruit types in Portugal. Nonetheless, given the current chilling values in Portugal and the relative importance of chilling accumulation for each fruit type, these changes are more significant for certain varieties of apples than for other types of fruit. Regarding forcing, the future projections highlight an increase in its values throughout the different fruit tree regions in Portugal, which should lead to earlier phenological timings. These changes may bring limitations to some of the most important Portuguese temperate fruit regions. The planning of suitable adaptation measures against these threats is critical to control the risk of exposure to climate change, thus warranting the future sustainability of the Portuguese fruit sector, which is currently of foremost relevance to the national food security and economy.
Kernel Nutrient Composition and Antioxidant Ability of Corylus spp. in China
Authors: Jiang Jiangzhao , Liang Lisong , Ma Qinghua , Zhao Tiantian
Published: June 2021

Hazelnut (Corylus) is an important woody oil tree species in economic forests. China, as one of the original countries of native Corylus species, had 8 species and 2 varieties. However, little information is available on the hazelnut nutritional quality of these Chinese Corylus species. In this study, four main wild Corylus species (C. heterophylla Fisch., C. mandshurica Maxim., C. kweichowensis Hu., and C. yunnanensis Franch.) originating in China and one main cultivar of hybrid hazelnut (Corylus heterophylla Fisch. × C. avellana L.) cv. ‘Dawei’ from China were used to analyze the basic nutritional composition (content of oil, fatty acid, protein, saccharide, aminao acid, vitamin C, tocopherol, total phenols, and total flavonoids) and antioxidant ability. The results showed that oil content ranged from 52.97 to 60.88 g/100 g DW and highly unsaturated fatty acid (UFA) content was over 91%. Oleic was the most dominant UFA in these hazelnut kernels, and the relative content was ranging from 71.32 to 85.19%. Compared with other four hazelnut kernels, C. heterophylla Fisch. was the lowest oil content of hazelnut with lower oleic acid content and higher linoleic acid content, obviously. The total protein content ranged from 13.15 to 18.35 g/100 g DW, and all amino acids were detected as hydrate amino acids, but Tryptophan, an essential amino acid, was not detected as free amino acid in these hazelnut kernels. Kernel of C. heterophylla Fisch. was with the highest content of protein and amino acid. Saccharose was the most essential and abundant disaccharide in the hazelnut kernels. C. mandshurica Maxim. was the highest saccharide content among these hazelnut kernels. α-tocopherol was the main type of tocopherol found in the hazelnut kernels. Wild hazelnut kernels generally had higher bioactivity substance content (vitamin C, total tocopherol, total phenol and total flavonoid) and antioxidant capacity. Compared to the four wild hazelnut kernels, the hybrid hazelnut cv. ‘Dawei’ had higher content of oil, oleic acid, α-tocopherol and sugar. Overall, there were great differences in the nutritional composition of different hazelnut species. Wild species are a good source of breeding materials because of their own characteristics in nutrition composition, and the hybrid hazelnut cv. ‘Dawei’ with good quality has the value of commercial promotion.
Job Demands and Job Resources of Academics in Higher Education
Authors: Naidoo-Chetty Mineshree , du Plessis Marieta
Published: June 2021

Too many job demands and not enough job resources can negatively influence the well-being of employees. Currently, limited information exists surrounding the job demands and resources as experienced by academic employees in the higher education sector. Therefore, the aim of this study was to identify the job demands and job resources experienced by academic employees using qualitative methods. Semi-structured interviews were conducted with 23 academic employees, using an Interpretative Phenomenological Approach. Thematic analysis, specifically template analysis was used to categorize the themes. Job demands were divided into three categories: quantitative (publication pressure, overburdened with the load, and competing time demands), qualitative (work/home balance, complexity of student support, organizational politics, and lack of mental health support) and organizational demands (using technology-mediated learning and lack of structural resources). Job resources were organized into two categories: organizational (social support) and personal resources (autonomy, meaningful work, and personal support). Participant experiences are highlighted to provide a better understanding of the job demands and job resources encountered. The framework of job demands and job resources gleaned from the study could be used for further research to manage and monitor motivational processes for academic staff, and to reduce strain due to high job demands.
Increasing Integrative Negotiation in European Organizations Through Trustworthiness and Trust
Authors: Elgoibar Patricia , Medina Francisco J. , Euwema Martin Claes , Munduate Lourdes
Published: June 2021

Integrative negotiation in which employers and employees create value is a major necessity in the current challenging context. Collective labor negotiations in organizations are traditionally focused on mostly distributive issues, such as pay, working hours, and holidays. However, the current situation demands the inclusion of other issues of a potentially more integrative nature, such as telework, sustainability, and risk prevention, the enhancement of which is a major challenge for organizations. In this study, we explore the negotiation process between management and employee representatives (ERs), analyzing the roles of trust and trustworthiness. We collected data from 614 human resources managers from different organizations in 11 European countries. The results confirm that ERs who management perceive to be trustworthy have a greater influence on negotiation, particularly with regard to integrative as opposed to distributive issues, and that trust partially mediates this relationship.
Cancer-Related Distress: How Often Does It Co-occur With a Mental Disorder? – Results of a Secondary Analysis
Authors: Ernst Jochen , Friedrich Michael , Vehling Sigrun , Koch Uwe , Mehnert-Theuerkauf Anja
Published: June 2021

Objectives

The Distress Thermometer (DT) is a validated and widely used screening tool to identify clinically relevant distress in cancer patients. It is unclear, to which extend subjectively perceived distress measured by the DT is related to objective burden (mental disorder). We therefore examine the co-occurrence of a mental disorder for different DT thresholds and explore the diagnostic properties of the DT in detecting a mental disorder.

Methods

In this multicenter cross-sectional study, we included 4,020 patients with mixed cancer diagnoses. After selection of relevant cases, weighting procedure and imputation of missing data we evaluated the data ofN= 3,212 patients. We used the DT to assess perceived distress and the standardized Composite International Diagnostic Interview for Oncology (CIDI-O) to assess the 4-week prevalence of mental disorders. The association between distress and any mental disorder (MD) is calculated using Pearson correlations. Relative risks for MD in patients with/without distress and the co-occurrence of distress and MD were calculated with Poisson regression. To assess the operating characteristics between distress and MD, we present the area under the curve (AUC).

Results

22.9% of the participants had a cut-off DT level of ≥5 and were affected by MD. Each level of distress co-occurs with MD. The proportion of patients diagnosed with MD was not greater than the proportion of patients without MD until distress levels of DT = 6 were reached. The correlation between DT and MD wasr= 0.27. The ROC-analysis shows the area under curve (AUC) = 0.67, which is classified as unsatisfactory. With increasing distress severity, patients are not more likely to have a mental disorder.

Conclusion

Our results suggests viewing and treating cancer-related distress as a relatively distinct psychological entity. Cancer-related distress may be associated with an increased risk for a mental disorder and vice versa, but the overlap of both concepts is very moderate.
Resilience Competence Face Framework for the Unforeseen: Relations, Emotions and Cognition. A Qualitative Study
Authors: Herberg Marius , Torgersen Glenn-Egil
Published: June 2021

The high impact of unforeseen events in a globalized world accentuates the importance of a greater in-depth and broader understanding of resilient competencies that can promote performance. Traditional research has, however, paid relatively little attention to uncertainty and unpredictable conditions, including the particulate competence of the unforeseen, and how organizations can achieve degrees of resilience. Hence, the purpose of this study is to explore whether there are types of competence at the individual, social and organizational level that can enhance preparedness to face the unforeseen. The first aim was to explore how highly experienced professionals from different sectors and organizational levels describe and understand the nature and function of the unforeseen phenomenon. The second aim was to explore what resilient competencies can be beneficially applied in organizations to enhance performance irrespective of the scenario or event that occurs. The generic qualitative approach of this study employed semi-structured interviews. The purposive expert sample of 13 highly knowledgably Norwegian professionals with unique and extensive cross-sectorial experience of unforeseen events were selected. Ages ranged from 41 to 62 years (M= 48.92,SD= 6.94), length of professional experience and education ranging from 22 to 43 years. Thematic analysis of interview transcripts and the interpretation displayed six types of resilience competence:(1) General Preparedness, (2) Characteristics and Competence of the Individual, (3) Sound Relations, (4) Creative Behavior and Improvisational Skills, (5) The Ability to Reflect and Learn, (6) Emotion Efficacy. In addition,The Unforeseenwas discerned as a complex phenomenon. These findings emphasize a cross-disciplinary perspective and provides integrative multilevel insight into the particulate competence of the unforeseen by introducing a framework that serves as a foundation for future research and as a tool for practitioners working in the field.
Red Junglefowl Chicks Seek Contact With Humans During Foraging Task
Authors: Rubene Diana , Løvlie Hanne
Published: June 2021

Contact seeking with humans is documented in some domestic animals, mainly dogs, which have advanced communication skills. Domestication as a companion animal is thought to underlie this ability. However, also domesticated horses and goats display similar human-directed behaviors. This suggests either a broader effect of domestication on contact-seeking behavior, or alternatively, that social interactions with humans can result in the development of human contact seeking. As part of another study, we observed contact-seeking behavior in juvenile red junglefowl (Gallus gallus) chicks exposed to behavioral training since hatching, during a foraging task, where chicks were singly required to collect food rewards in a familiar arena using odor cues. If chicks left the arena, we recorded if they approached and looked up at the experimenter, or if they approached other objects (including another human). Chicks approached the experimenter significantly more often than they approached other objects. This behavior was not linked to a fast performance in the test arena, which gave some birds more time to explore the surroundings, or to learning ability measured in a cognitive task. Yet, the preference for the experimenter was lower for chicks that were handled more prior to the experiment. Also, approach probability was positively correlated with escape attempts in a novel arena test. The observed variation in approach behavior suggests a link to aspects of personality, and exposure to human interactions and experimental procedures. Our observations suggest that, although neither domesticated nor selectively bred, red junglefowl that are socialized with humans can potentially develop behavior used to describe contact seeking. Together with evidence from cognitive and behavioral studies, our results suggest that social experiences, not only domestication, can affect human-animal interactions. We propose how interactions between behavior, cognition and handling could be studied further in controlled settings to validate the preliminary findings of our study and uncover the underlying mechanisms.
State Anhedonia in Young Healthy Adults: Psychometric Properties of the German Dimensional Anhedonia Rating Scale (DARS) and Effects of the COVID-19 Pandemic
Authors: Wellan Sarah A. , Daniels Anna , Walter Henrik
Published: June 2021

Healthy reward processing is a complex interplay of several components. Recent self-report measures of anhedonia, the decrease or loss of hedonic capacity, take this complexity into account. The Dimensional Anhedonia Rating Scale (DARS) measures interest, motivation, effort and consummatory pleasure across four domains: hobbies, food/drink, social activities and sensory experiences. In the present cross-sectional survey study, we validated the German version of the DARS in a sample of 557 young healthy adults. Factor structure as well as convergent and divergent validity were assessed. As a secondary aim, we examined the effects of the COVID-19 pandemic on state anhedonia and depression severity. Our results suggest good convergent and divergent validity and high internal consistency of the German DARS. The original differentiation of four factors mapping onto the four domains was confirmed and measurement invariance before and during the COVID-19 pandemic was established. We conclude that the DARS is a valid instrument to comprehensively assess state anhedonia in healthy German samples. Future studies should further assess the utility of the German DARS in clinical contexts. In line with many previous studies, participants during the pandemic reported significantly higher levels of depressive symptoms compared to participants in the months before. We found no indication that the COVID-19 pandemic affected state hedonic capacity.
Attitudes Toward Four Levels of Self-Driving Technology Among Elderly Drivers
Authors: Lajunen Timo , Sullman Mark J. M.
Published: June 2021

Automatization and autonomous vehicles can drastically improve elderly drivers' safety and mobility, with lower costs to the driver and the environment. While autonomous vehicle technology is developing rapidly, much less attention and resources have been devoted to understanding the acceptance, attitudes, and preferences of vehicle automatization among driver groups, such as the elderly. In this study, 236 elderly drivers (≥65 years) evaluated four vehicles representing SAE levels 2–5 in terms of safety, trustworthiness, enjoyment, reliability, comfort, ease of use, and attractiveness, as well as reporting preferences for vehicles employing each of the four levels of automation. The results of a repeated-measures ANOVA showed that the elderly drivers rated the SAE level 2 vehicle highest and the fully automated vehicle (SAE 5) lowest across all attributes. The preference for the vehicle declined as a function of increasing automatization. The seven attributes formed an internally coherent “attitude to automatization” scale, a strong correlate of vehicle preference. Age or annual mileage were not related to attitudes or preferences for automated vehicles. The current study shows that elderly drivers' attitudes toward automatization should be studied further, and these results should be taken into account when developing automated vehicles. The full potential of automatization may not be realized if elderly drivers are ignored.
The Impact of General Self-Efficacy on Psychological Resilience During the COVID-19 Pandemic: The Mediating Role of Posttraumatic Growth and the Moderating Role of Deliberate Rumination
Authors: Zeng Wei , Wu Xingrou , Xu Yanhua , Wu Jiamin , Zeng Yuqing , Shao Jinlian , Huang Dongtao , Zhu Ziqi
Published: June 2021

Purpose: This study used a moderated mediation model to explore the relationship between general self-efficacy (GSE) and psychological resilience (PR) and the associated mechanisms, the mediating role of posttraumatic growth (PTG), and the moderating role of deliberate rumination (DR) during the coronavirus disease 2019 (COVID-19) pandemic. Knowledge of the relationship between these four variables examined further understanding of the PR improvement mechanism of college students and even the general public.

Methods: The college students who participated in this study came from an independent college in Guangdong Province, China. A total of 918 college students completed the survey, and the final data sample size was 881. SPSS 23.0 and PROCESS (version 3.3) were used to conduct Pearson's correlation analysis and hierarchical regression linear analysis on the data.

Results: (1) The correlation analysis showed that GSE and PR were positively correlated and that PTG was positively correlated with GSE and PR. DR was positively correlated with GSE, PTG, and PR. (2) The results of mediation analysis showed that GSE had a direct predictive effect on DR, and PTG partially mediated the relationship between the two. (3) The results of moderating effect analysis showed that DR hindered the effect of GSE on PTG but enhanced the positive impact of PTG on PR.

Conclusions: General self-efficacy can improve PR under the mediating influence of PTG. DR played a positive moderating role in the relationship between GSE and PTG, and played a negative moderating role in the relationship between PTG and PR. These results advance the understanding of the mechanism between GSE and PR.
Teleworking in Times of COVID-19: Effects on the Acquisition of Personal Resources
Authors: Pulido-Martos Manuel , Cortés-Denia Daniel , Lopez-Zafra Esther
Published: June 2021

The COVID-19 pandemic has forced many employees to introduce different degrees of teleworking, leading to a transformation of the psychosocial work environment. In this study, we analyzed whether the relationship between a labor resource, social support, and a personal resource, vigor at work, is affected by the work modality (face-to-face, hybrid that includes face-to-face work and telework time, and telework caused by the current pandemic situation). Five hundred and forty-three employees answered an online questionnaire about their perceptions of the levels of social support, vigor experienced in the last month, and work modality. Seniority in the organization and the gender of the employees were controlled for. The model fit was significant [F(7, 535)= 20.816,p< 0.001], accounting for 21% of the variation in vigor (R2= 0.21). The interaction was also significant [F(2, 535)= 4.13,p< 0.05], with an increase of 1% in the explanation of the variance in vigor at work (ΔR2= 0.01). Differences were found in the positive relationship between levels of social support and vigor at work, among the face-to-face and telework modalities (hybrid and telework), but not between teleworking modalities. As a result, we posit that the different forms of telework moderate (buffer) the relationship experienced between labor resources (social support) and personal resources (vigor at work). This implies that, for the design of teleworking conditions, it is necessary to provide work resources similar to those in face-to-face settings, such as social support.
Sound Effects on Physiological State and Behavior of Drivers in a Highway Tunnel
Authors: Yang Yanqun , Feng Yang , Easa Said M. , Yang Xiujing , Liu Jiang , Lin Wei
Published: June 2021

Driving behavior in a highway tunnel could be affected by external environmental factors like light, traffic flow, and acoustic environments, significantly when these factors suddenly change at the moment before and after entering a tunnel. It will cause tremendous physiological pressure on drivers because of the reduction of information and the narrow environment. The risks in driving behavior will increase, making drivers more vulnerable than driving on the regular highways. This research focuses on the usually neglected acoustic environment and its effect on drivers' physiological state and driving behavior. Based on the SIMLAB driving simulation platform of a highway tunnel, 45 drivers participated in the experiment. Five different sound scenarios were tested: original highway tunnel sound and a mix of it with four other sounds (slow music, fast music, voice prompt, and siren, respectively). The subjects' physiological state and driving behavior data were collected through heart rate variability (HRV) and electroencephalography (EEG). Also, vehicle operational data, including vehicle speed, steering wheel angle, brake pedal depth, and accelerator pedal depth, were collected. The results indicated that different sound scenarios in the highway tunnel showed significant differences in vehicle speed (p = 0.000, η2 = 0.167) and steering wheel angle (p = 0.007, η2 = 0.126). At the same time, they had no significant difference in HRV and EEG indicators. According to the results, slow music was the best kind of sound related to driving comfort, while the siren sound produced the strongest driver reaction in terms of mental alertness and stress level. The voice-prompt sound most likely caused driver fatigue and overload, but it was the most effective sound affecting safety. The subjective opinion of the drivers indicated that the best sound scenario for the overall experience was slow music (63%), followed by fast music (21%), original highway tunnel sound environment (13%), and voice-prompt sound (3%). The findings of this study will be valuable in improving acoustic environment quality and driving safety in highway tunnels.
Factors Related to the Level of Depression and Suicidal Behavior Among Men With Diagnosed Depression, Physically Ill Men, and Healthy Men
Authors: Kielan Aleksandra , Jaworski Mariusz , Mosiołek Anna , Chodkiewicz Jan , Święcicki Łukasz , Walewska-Zielecka Bożena
Published: June 2021

Depression is the most common psychiatric disorder in people who die by suicide. Awareness of risk factors for suicide in depression is important for clinicians. The study was aimed at establishing models of factors related to the level of depression and suicidal behavior among men from three different groups—in men with depressive disorder, in comparison to men with physical disorder and healthy men. A total of 598 men were included in the study. The following questionnaires were used in research model: test with sociodemographic variables, AUDIT Test, Fagerström Test, Generalized Self-Efficacy Scale (GSES), Inventory for Measuring Coping with Stress (Mini-COPE), Resilience Evaluation Questionnaire (KOP-26), Suicide Behaviors Questionnaire—Revised (SBQ-R) by Osman, and Gotland Male Depression Scale. In men with depression, the positive factors strongly related to the intensity of depression and suicidal behavior were as follows: vocational education, active coping, turning toward religion, social competence for resilience, and bachelor status. The factors negatively related to the intensity of depression and suicidal behavior in this group were as follows: unemployed status, student status, low satisfaction with the financial situation, having children, history of mental disorders in family, alcohol addiction, and seeking instrumental support. In the group of men with physical disorders, the following protection factors were identified: the medium or small city as a place of living, active coping, venting, and personal competence. The following risk factors were identified in this group: psychiatric treatment in the past. In the group of healthy men, the following protective factors were identified: the medium city as a place of living, positive reappraisal, planning abilities, and personal and social competence for resilience. In this group, the following risk factors were identified: vocational and higher education, student status, satisfaction with the financial situation, having more than one children, the occurrence of mental disorders in the family, the occurrence of alcohol abuse in the family, and use of psychoactive substances as a strategy of dealing with stress. The risk factors identified in this study should be included in the clinical assessment of depression and suicidal behavior risk in male patients. There are some protective factors identified, including productive coping and personal and social competencies, which can be developed and should be especially considered and strengthened in mental health promotion programs aimed at men.
Blood Pressure Changes After a Health Promotion Program Among Mexican Workers
Authors: Garcia-Rojas Isabel J. , Omidakhsh Negar , Arah Onyebuchi A. , Krause Niklas
Published: June 2021

Background: Cardiovascular disease is becoming increasingly prevalent in low and middle-income countries (LMIC), and high blood pressure (BP) is one of the main risk factors. The efficacy and sustainability of worksite health promotion (WHP) programs for BP reduction in LMIC have yet to be determined.

Methods: This non-randomized company-based trial evaluated 6- and 12-months effects of a WHP intervention on BP among 2,002 participating workers from seven Mexican companies. Intervention and control groups were assigned at the company level. The intervention included nutrition counseling, physical exercise, and stress management components. Mixed models assessed differences in BP change between intervention and control companies in intent-to-treat (ITT), per-protocol (PerP), and as-treated (AsTr) analyses, and also within-group changes stratified by company, intervention component, and baseline cardiovascular risk factor levels. All analyses were adjusted for potential confounders. We accounted for missing data and loss to follow-up using inverse probability of censoring weighting.

Results: ITT analyses revealed mean BP change differences of −1.1 mmHg at 12 months (95% CI: −2.9; 0.6) in intervention companies relative to control companies. PerP and AsTr analyses confirmed this finding. Within-group analyses showed consistent BP reductions at both 6 and 12 months. Substantial differences in BP changes ranging from diastolic −6.1 mmHg, (95% CI: −11.2; −1.2) to systolic −13.0 mmHg (95% CI: −16.0; −10.1) were found among individuals with diabetes at baseline in intervention companies relative to control companies.

Conclusion: After 1 year, WHP was associated with modest but uncertain BP reductions. Substantial reductions were mainly observed among diabetic workers.
Targeting Stress-Response Pathways and Therapeutic Resistance in Head and Neck Cancer
Authors: Bos Tasia , Ratti J. Alex , Harada Hisashi
Published: June 2021

Head and neck cancer is the sixth leading cancer worldwide; head and neck squamous cell carcinoma (HNSCC) accounts for more than 90% of incident cases. In the US, cases of HNSCC associated with human papillomavirus (HPV) have been growing in proportion amongst a younger demographic with superior outcomes to the same treatments, relative to cases associated with tobacco. Yet failures to improve the long-term prognosis of advanced HNSCC over the last three decades persist in part due to intrinsic and acquired mechanisms of resistance. Deregulation of the pathways to respond to stress, such as apoptosis and autophagy, often contributes to drug resistance and tumor progression. Here we review the stress-response pathways in drug response and resistance in HNSCC to explore strategies to overcome these resistance mechanisms. We focus on the mechanisms of resistance to current standard cares, such as chemotherapy (i.e., cisplatin), radiation, and cetuximab. Then, we discuss the strategies to overcome these resistances, including novel combinations and immunotherapy.
Advancing Seaport Resilience to Natural Hazards Due to Climate Change: Strategies to Overcome Decision Making Barriers
Authors: Mclean Elizabeth L. , Becker Austin
Published: June 2021

Climate change and extreme weather events put in peril the critical coastal infrastructure that is vital to economies, livelihoods, and sustainability. However, for a variety of reasons, decision makers often do not implement potential adaptation strategies to plan and adjust to climate and extreme weather events. To respond to the question of how seaport decision makers perceive strategies to overcome the barriers to adaptation we used semi-structured interviews of 30 seaport directors/managers, environmental specialists, and safety managers from 15 medium- and high-use ports of the U.S. North Atlantic. This paper contributes four broad strategies identified by seaport decision makers as necessary to help them advance on this challenge: funding, better planning or guidance, research and education, and advocacy/lobbying. We coded these strategies parallel to our partner paper that identified seven key barriers faced by the same set of decision makers. Results can help direct resources in ways targeted to the needs of seaport decision makers. The proposed framework contributes to theories of resilience building and barriers to decision making. Being strategic about change facilitates effective adaptation, decreasing risk, and enables continuity of safe, and sustainable, operations of U.S. seaports in the face of climate and extreme weather events.
Ground Frosts in Poland in the Growing Season
Authors: Koźmiński Czesław , Nidzgorska-Lencewicz Jadwiga , Mąkosza Agnieszka , Michalska Bożena
Published: June 2021

The ongoing climate warming affects, among others, and the variability of thermal conditions in spring and autumn are resulting in earlier dates of the beginning and end of the growing season. The present paper provides detailed characteristics of the phenomenon of ground frosts, addressing the question of whether the risk of frost-related damage in the extending growing season is still present. The assessment of temporal and spatial distribution of ground frosts (5 cm above ground level-AGL) in Poland in the thermal growing season (AT > 5 °C) was conducted on the basis of the results of air temperature measurements at 5 and 200 cm a.g.l. obtained from 52 station of the Institute of Meteorology and Water Management—National Research Institute for the period 1971–2020. The thermal growing season was calculated using the method by Gumiński. The following were calculated: the dates of the occurrence of ground frosts in spring and autumn, duration of the frost-free period, the number of days with frosts of various intensity, according to years, ten-day period and days in a year together with trends of change. The conducted analysis demonstrated that the number of days with frosts in the thermal growing season in the multiannual period under analysis (1971–2020) does not show any statistically significant changes. It was found that in the thermal growing season, the average number of days with ground frosts in Poland amounts to 28 and ranges in spring from 15 to 22, and in autumn from 8 to 12. Most frequently, approx. 49%, slight frosts are recorded, followed by moderate (29%), severe (15%) and very severe (7%). A positive effect of water reservoirs on decreasing the frequency and intensity of frosts, as well as sporadic occurrence of the phenomenon in the second half of June were demonstrated. Statistically significant earlier dates of disappearance of frosts in spring, later dates of occurrence in autumn and the lengthening of the frost-free period from approximately 2 days in the north-east of Poland to approximately 8.0 days over 10 years in the Pomerania region, create increasingly more favourable conditions for the cultivation of plants with high thermal requirements in Poland.
Effect of Forage Processor Roll Gap Width and Storage Length on Fermentation Profile, Nutrient Composition, Kernel Processing Score, and Starch Disappearance of Whole-Plant Maize Silage Harvested at Three Different Maturities
Authors: Saylor Benjamin A. , McCary Cody L. , Diepersloot E. Cole , Heinzen Celso , Pupo Matheus R. , Gusmão Jéssica O. , Ghizzi Lucas G. , Sultana Halima , Ferraretto Luiz F.
Published: June 2021

Our objective was to assess the effect of forage processor roll gap width and storage length on fermentation, nutrient composition, kernel processing score (KPS), and ruminal in situ starch disappearance (isSD) of whole-plant maize silage harvested at different maturities. Samples from a single maize silage hybrid at three harvest maturities (1/4, 1/2, and 3/4 kernel milk line (early, intermediate, and late, respectively)) processed with two roll gap widths (1 and 3 mm) were collected and stored in quadruplicate vacuum pouches for 0, 30, 120, or 240 d. Lactic acid concentrations were greater, and pH was reduced in early and intermediate maturity silage compared to late maturity silage. Ruminal isSD was greatest for early maturity silage, intermediate for the intermediate maturity silage, and lowest for the late maturity silage, but differences in isSD due to maturity were diminished after prolonged storage. Kernel processing score was greatest in late maturity silage processed through a 1 mm roll gap and lowest in late maturity silage processed through the 3 mm roll gap. For early and intermediate maturity silages, no differences in KPS were observed between the two roll gap widths. Minimal effects of maturity and roll gap width on fatty acids (FA) and amino acids (AA) were observed. Concentrations of total AA decreased as storage length progressed. Results support the premise that the silo is a dynamic system that undergoes numerous chemical changes throughout the storage period.