bluuebunny/crossref_metadata_2025 huggingface dataset:
Fit for purpose - developing a software platform to support the modern challenges of data linkage in Western Australia
Authors: Eitelhuber Tom Walter , Thackray James , Hodges Steve , Alan Janine
Published: November 2018

The Western Australia Data Linkage System (WADLS) is maintained and operated by the WA Data Linkage Branch (DLB) at the Western Australian Department of Health. DLB has pioneered a number of data linkage innovations, including the facilitation of genealogical research via the Family Connections system and streamlined data delivery via the Custodian Administered Research Extract Server. DLB’s latest innovation is a new data linkage system called “DLS3”, which improves DLB’s capability and capacity to handle the increasing volume and complexity of its routine operations. DLS3 was built entirely in-house and customised to meet the specific challenges that DLB has encountered throughout over twenty years of experience with a wide variety of linkages. This article describes the development and rollout of DLS3, including its design, architecture, benefits and limitations.
International Network for Exchanging Experience on Statistical Handling of Granular Data (INEXDA).
Authors: Hirsch Christian
Published: November 2018

The financial crisis of 2007/08 has highlighted the need for using granular data on financial institutions and markets to detect risks and imbalances in the financial sector. Administrative data producers are witnessing a growing need to improve granular data access and sharing. When sharing granular data, data producers face significant legal and technical challenges related to, among others, safeguarding statistical confidentiality.

To meet the demand of data users and data compilers for (granular) data sharing, the International Network for Exchanging Experience on Statistical Handling of Granular Data (INEXDA) was established on 6 January 2017. Current INEXDA members are the Banco de España, Banca d'Italia, the Banco de Portugal, the Bank of England, the Banque de France, the Deutsche Bundesbank, and the European Central Bank.

INEXDA provides a platform for administrative data producers to exchange practical experiences on the accessibility of granular data, on metadata as well as on techniques for statistical analysis and data protection. During the INEXDA meeting in Paris, Julia Lane has presented the Administrative Data Research Facility (ADRF). Following her presentation several INEXDA members expressed interest in obtaining more information about the approach taken by ADRF. This presentation describes the interaction between INEXDA and ADRF.

The views expressed here are those of the author and do not necessarily reflect those of the Deutsche Bundesbank, ADRF, or the INEXDA Network.
The National Information Exchange Model and making data relevant
Authors: Wormeli Paul
Published: November 2018

The National Information Exchange Model (NIEM) has been widely adopted as a basis for creating standards that foster information exchanges across disparate disciplines in justice, health, human services and other fields.  NIEM can be a driver for transforming legacy data into meaningful cross-disciplinary exchanges that can support advanced analysis of impacts of programs and strategies in improving government services of all categories.  This presentation will review the basic NIEM principles in terms of how they can enable more meaningful results as administrative data is applied to research on the efficacy of government services across organizations and disciplines.
Harnessing Administrative Records for Official Statistics on People and Households
Authors: Heggeness Misty L
Published: November 2018

The availability and excessiveness of alternative (non-survey) data sources, collected on a daily, hourly, and sometimes second-by-second basis, has challenged the federal statistical system to update existing protocol for developing official statistics. Federal statistical agencies collect data primarily through survey methodologies built on frames constructed from administrative records. They compute survey weights to adjust for non-response and unequal sampling probabilities, impute answers for nonresponse, and report official statistics via tabulations from these survey. The U.S. federal government has rigorously developed these methodologies since the advent of surveys -- an innovation produced by the urgent desire of Congress and the President to estimate annual unemployment rates of working age men during the Great Depression.

In the 1930s, Twitter did not exist; high-scale computing facilities were not abundant let alone cheap, and the ease of the ether was just a storyline from the imagination of fiction writers. Today we do have the technology, and an abundance of data, record markers, and alternative sources, which, if curated and examined properly, can help enhance official statistics. Researchers at the Census Bureau have been experimenting with administrative records in an effort to understand how these alternative data sources can improve our understanding of official statistics. Innovative projects like these have advanced our knowledge of the limitations of survey data in estimating official statistics. This paper will discuss advances made in linking administrative records to survey data to-date and will summarize the research on the impact of administrative records on official statistics.
Housing Affordability: Local and National Perspectives
Authors: Goodman Laurie , Li Wei , Zhu Jun
Published: November 2018

This paper presents a new approach to measuring affordable homeownership. Future changes in the homeownership rate will depend on the ability of today’s renters to become homeowners. Our proposed housing affordability for renters index (HARI) focuses on how affordable homeownership is for current renters. We look at the share of renters who reported the same or more income than those who recently purchased a home using a mortgage, in effect measuring how many renters have enough income to purchase a house. For each metropolitan statistical area (MSA), we construct a local area index that compares renters and borrowers in the same MSA and a national index that compares renters nationwide with homeowners in a specific MSA. We rely on the Administrative Data Research Facility to construct these indices. This database, constructed by the Urban Institute, aggregates American Community Survey variables and Home Mortgage Disclosure Act variables to common geographies. The new indices reveal that slightly more than a quarter of current US renters have incomes higher than those who recently became homeowners using a mortgage. The indices also reveal how housing affordability differs over time and across race/ethnicity groups and locations. We demonstrate the value of our new indices by showing that they are predictive of homeownership rates: MSAs that are deemed more affordable by our index have higher homeownership rates.
Building a repository for record linkage
Authors: Leonard Susan Hautaniemi , Israel Abay , Levenstein Margaret , Alexander Trent
Published: November 2018

ICPSR is building LinkageLibrary, a repository and community space for researchers involved in linking and combining datasets, as a collaboration between social, statistical, and computer scientists. Unlike surveys or experiments where causal and outcome variables are measured in tandem, it is often necessary when working with organic, non-design data to link to other measures. This makes linkage methodologies particularly important when conducting analyses using administrative data. A common benchmarking repository of linkage methodologies will propel the field to the next level of rigor by facilitating comparison of different algorithms, understanding which types of algorithms work best under different conditions and problem domains, promoting transparency and replicability of research, and encouraging proper citation of methodological contributions and their resulting datasets. It will bring together the diverse scholarly communities (e.g., computer scientists, statisticians, and social, behavioral, economic, and health (SBEH) scientists) who are currently addressing these challenges in disparate ways that do not build on one another’s work. Improving linkage methodologies is critical to the production of representative samples, and thus to unbiased estimates of a wide variety of social and economic phenomena. The repository will accelerate the development of new record linkage algorithms and evaluation methods, improve the reproducibility of analyses conducted on integrated data, allow comparisons on same and different data, and move forward the provision of privacy-aware integrated data. The presentation will focus on lessons learned while building the repository and the community, and introduce the LinkageLibrary website.
Record Linkage Reconciliation of Arlington Department of Human Services Administrative Data Using Potts Models
Authors: Crandell Ian , Schroeder Aaron , Higdon Dave , Irwin Michael-dharma
Published: November 2018

Situated at the nexus of federal, state, and local governments, the Arlington Department of Human Services (DHS) receives service utilization data from a multitude of different sources. Because of their “no wrong door” policy, customers can sign up for any DHS service from any DHS department. A practical consequence of this is that a single person can appear as multiple records from multiple databases with no unambiguous key between these records. Merging these records requires a probabilistic linkage approach. Classical approaches to record linkage, such as the method of Felligi and Sunter, consider each possible pair of records between databases and assigning link probabilities to each one. A drawback of considering pairwise links alone is that sometimes the transitive nature of links is violated. In order to better handle such information clashes, we propose a Bayesian linkage method that considers a large set of possible pairs at once. At the heart of this approach is a Potts model representation that tracks which records are assigned to the same individual. This allows us to assign probabilities to the various reconciliations of inconsistent linkage assignments.
Simulation Approach to Assess the Precision of Estimates Derived from Linking Survey and Administrative Records
Authors: Resnick Dean M , Mirel Lisa B
Published: November 2018

Probabilistic record linkage implies that there is some level of uncertainty related to the classification of pairs as links or non-links vis-à-vis their true match status. As record linkage is usually performed as a preliminary step to developing statistical estimates, the question then is how does this linkage uncertainty propagate to them? In this paper, we develop an approach to estimate the impact of linkage uncertainty on derived estimates by using a re-sampling approach. For each iteration of the re-sampling, pairs are classified as links or non-links by Monte-Carlo assignment to model estimated true match probabilities. By looking at the range of estimates produced in a series of re-samples, we can estimate the distribution of derived statistics under the prevailing incidence of linkage uncertainty. For this analysis we use the results of linking the 2014 National Hospital Care Survey to the National Death Index performed at the National Center for Health Statistics. We assess the precision of hospital-level death rate estimates.
Key Factors in the establishment of an academia-government center of public sector administrative data and policy research
Authors: Ayles James , McDonald Ted
Published: November 2018

A collaborative between the Government of New Brunswick (GNB) and the University of New Brunswick to establish a center of public sector administrative data and policy research was envisioned in 2012. Subsequent work between the parties led to the establishment of the New Brunswick Institute for Research, Data and Training (NB-IRDT) in 2014.

Academia-government partnerships are not unique in Canada, however what sets this apart is: 1) the legislative approach used to support research, 2) scope of administrative data made available, 3) value placed on anonymized linked data, 4) governance overseeing the partnership, and 5) measures taken to ensure the protection of citizens’ data.

In 2017, the New Brunswick Act Respecting Research received proclamation. This Act serves to provide clarity and addresses gaps in access and use of personal / health data for research. The Act has opened the doors for NB-IRDT with data owners of public sector organizations. NB-IRDT may now receive pseudonymous personal data from any public sector program collecting personal information.

The partnership is governed by several advisory committees each serving a different role in overseeing the growth of NB-IRDT; overall direction setting being led by a panel of Deputy Ministers and the Clerk (the senior ranking civil servant in GNB.)

The collaboration is well positioned to support public policy research and fosters the use of evidence-based information in the development of government programs and services. The partnership has also helped to encourage new and innovative thinking within GNB about the value of linkable data to support decision-making.
Demonstrating the Use of Linked Data to Advance Education Research
Authors: Porter Sonya R , Pharris-Ciurej Nick , Penner Emily , Brummet Quentin
Published: November 2018

Linking K-12 data on students and teachers to Internal Revenue Service (IRS) information allows us to answer questions that are difficult to answer using survey data or educational administrative data alone. We describe two research projects that demonstrate the importance of using linked administrative data to further research on education and inform policy discussions. In the first research project, using linked IRS income tax data to school administrative records for all 8th graders in one California public school district and all K-12th graders in Oregon public schools, we examine how well free and reduced price lunch (FRPL) enrollment captures student disadvantage. We find that FRPL categories capture relatively little variation in household income. However, FRPL captures elements of educational disadvantage that IRS-reported household income data do not. In the second research project, using data on teachers from a large California school district linked to IRS records and the Business Register, we examine what teachers do after they leave teaching. Preliminary findings suggest that many teachers leave the workforce after they leave teaching. Teachers that continue to work after leaving our school district often do so in a nearby school district, and often see a modest increase in their earnings in their new positions.
Evaluating the impact of workers' compensation policy in Australia using insurance claims data and comparative quasi-experimental methods
Authors: Collie Alex , Lane Tyler , Gray Shannon
Published: November 2018

Australia, like the USA, has state-based workers’ compensation (WC) systems that provide income support, healthcare and rehabilitation for injured and ill workers. The eleven major Australian WC systems provide coverage for over 90% of the labor force and accept approximately one quarter of a million new claims per annum. Governments commonly use changes in scheme design (most often enacted through legislative amendment) to influence WC system performance including rates of claiming, costs and return to work (RTW) outcomes. Using a national, longitudinal, case level dataset of WC insurance claims data, we evaluated the impact of multiple, state level legislative amendments. The impact of legislative amendments in the states of South Australia (year of 2009), Tasmania (2010), Victoria (2010) and New South Wales (2012) were evaluated using interrupted time series analysis. Outcomes included volume and incidence of accepted WC claims, employer and insurer claim processing timeframes, and duration of work disability. Major findings include (1) the Tasmanian amendments designed to improve RTW outcomes failed; (2) the South Australian amendments designed to encourage early employer claim lodgment were partially effective; (3) the New South Wales amendments designed to ensure the financial viability of the WC scheme reduced access to benefits and disproportionately affected workers with occupational disease and mental health conditions; (4) the Victorian amendments designed to increase benefit generosity led to an increase in claims and longer duration of disability. Study findings demonstrate both intended and unintended consequences of WC system reform, and provide an evidence base for future reform.
The power of linked data: Evaluating diverse multi-program projects designed to reduce welfare dependence
Authors: Povey Jenny , Baxter Janeen , Ambrey Christopher , Kalb Guyonne , Ribar David , Western Mark
Published: November 2018

This presentation showcases the innovative use of linked government administrative data in Australia to evaluate a range of diverse social interventions aimed at supporting vulnerable groups to achieve economic independence. The interventions were developed and funded as part of the Australian Priority Investment Approach to Welfare, an approach supported by actuarial analyses of administrative data designed to deliver targeted support for groups at-risk of long-term welfare dependence. In 2018, the Australian Government, commissioned an impact evaluation to assess the effectiveness of the approach in achieving its intended outcomes. The evaluation is based on analyses of linked administrative data to assess the extent to which the new interventions enabled pathways out of welfare dependence. Our presentation will outline the strengths and weaknesses of using government administrative data to evaluate the outcomes. Strengths include easy comparison across diverse programs designed to achieve the same goals; reduced respondent reporting burdens; robust quasi-experimental techniques such as a matching design based on exact matching on a few key characteristics and/or propensity score matching on a broad range of pre-program characteristics; and evidence-based investment practice decisions. Weaknesses include the adoption of an observational rather than experimental design and the lack of information on some social characteristics such as orientations to work, attitudes and social values. The presentation not only assesses the compilation of administrative data used for the first time to evaluate multi-program projects, it will also describe how these data feed into visual interactive dashboards used to monitor the outcomes of the interventions.
Policy and resource optimization based on spatial risk prediction models for child maltreatment
Authors: Daley Dyann
Published: November 2018

Spatial risk prediction models describe the features of small spatial units which support or attract child maltreatment behaviors. Due to shared risk factors, community problems such as infant mortality, poor educational readiness, injury-related deaths, and a host of physical and mental health problems associated with toxic stress co-occur in these small areas. Based on administrative data, this spatial intelligence brings cross-sector stakeholders together to collaboratively plan for optimization of critical supports, capacity development for vital services, improvement of professional response, development of supportive infrastructure, and creation of healthier social norms. We present the policy and resource optimization strategies being developed in locations implementing the Predict-Align-Prevent program for child maltreatment prevention.
Social Responsibility and Its Relation with Procrastination and Achievement Motivation among Students of Imam Abdulrahman Bin Faisal University
Authors: Alhoish Fatema K.
Published: November 2018

This study aimed at identifying the level of social responsibility, procrastination and achievement motivation among Imam Abdulrahman Bin Faisal University students in Dammam, Saudi Arabia. It also aimed to explore the correlational relations between social responsibility, procrastination and achievement motivation and to uncover the differences between male and female students on these three variables. The study was conducted on a sample of 1880 male and female students. Social responsibility, and procrastination scales, as well as the achievement motivation test were employed after verifying their psychometric properties. The results showed that while the university students practice both social responsibility and procrastination at a medium level, they practice achievement motivation at a high level. The study further showed a significant, negative correlation between social responsibility and procrastination, and significant positive correlation between responsibility and achievement motivation. Furthermore, the study showed statistically significant differences between males and females in social responsibility and procrastination in favour of male students; and statistically significant differences in the achievement motivation in favor of females.
Could Resilience and Flourishing be Mediators in the Relationship between Mindfulness and Life Satisfaction for Saudi College Students? A Psychometric and Exploratory Study
Authors: Younes Marei S. , Alzahrani Mohammed R.
Published: November 2018

In There are few Arabic studies examining the disposition of mindfulness, resilience, and well-being of college students. The purpose of the present study is to examine the factor structure and internal consistency of the Arabic version of mindful attention awareness scale (MAAS) and the brief resilience scale, and  to test a model that describes the role of resilience and well-being, in relation to mindfulness and life satisfaction. For this reason, a study of two folds was conducted with the assistance of Umm Al-Quraa University students (n = 562; n = 534). Mindfulness, resilience, flourishing and life satisfaction scales are the variables that were used. Results show that both mindfulness and resilience scales were revealed to be unidimensional and have high reliability estimates. Both resilience and flourishing are partial mediators in the relationship between mindful and life satisfaction. In addition, resilience had an impact on flourishing. Mindfulness partially had an effect on life satisfaction. In conclusion, mindfulness and resilience scales had good structural validity and reliability.
ВИЗНАЧЕННЯ СТАЛОЇ ВІДДАЛЕМІРА ЕЛЕКТРОННОГО ТАХЕОМЕТРА В ЛІНІЙНО-КУТОВІЙ МЕРЕЖІ
Authors: Kryachok Serhiy
Published: November 2018

Актуальність теми дослідження. В Україні нині широко застосовуються новітні методи створення геодезичних мереж із використанням супутникових технологій. Актуальним залишається побудова полігонометричних мереж із використанням електронних тахеометрів.
Постановка проблеми. Для визначення відстаней, виміряних електронними тахеометрами, необхідно періодично визначати постійну поправку (сталу) віддалеміра електронного тахеометра.
Аналіз останніх досліджень і публікацій. Були розглянуті останні публікації у відкритому доступі, які присвячені висвітленню способів визначення сталої віддалемірів електронних тахеометрів.
Виділення недосліджених частин загальної проблеми. Потребує подальшого розвитку розробка методик визначення сталої не як окремої вимірювальної процедури, а за результатами вимірювань у геодезичних мережах.
Постановка завдання. Необхідно розробити методику визначення сталої віддалеміра електронного тахеометра за даними вимірювань у лінійно-кутовій мережі у вигляді трикутника з відомою базисною стороною.
Виклад основного матеріалу. Розглянуто особливості методику визначення сталої віддалеміра електронного тахеометра за даними вимірювань у лінійно-кутовій мережі у вигляді трикутника з відомою базисною стороною, виміряними двома сторонами та виміряними щонайменше двома горизонтальними кутами. Виконано апробацію розробленої методики на конкретній лінійно-кутовій мережі з використанням електронного тахеометра Trimble 3305 та відбивача від електронного віддалеміра СТ5 «Блеск».
Висновки відповідно до статті. Значення сталої дорівнює -44 мм, яке визначено із середньою квадратичною похибкою 4,7 мм. У результаті розрахунків встановлено, що точність визначення сталої за даними вимірів у наведеній лінійно-кутовій мережі в 1,9 раза вища за точність її визначення з використанням базисної відстані.
Formulation and Evaluation of Microemulsion Based Topical Gel of Carbamazepine
Authors: S V Shirolkar , J S Padhiar , S S Deshkar
Published: November 2018

Carbamazepine(CBZ) is a synthetic compound of the benzodiazepine class, used as an anticonvulsant and analgesic drug. Carbamazepine is relatively slowly but well absorbed after oral administration. Its plasma half-life is about 30 hours when it is given as single dose, but it is a strong inducer of hepatic enzymes and the plasma half-life shortens to about 15 hours when it is given repeatedly. Psoriasis is autoimmune disease in which genetic and environmental factors have a significant role. Carbamazepine was accidently discovered to have antipsoriatic properties. Carbamazepine was obtained as a gift sample from Lupin. Characterization of carbamazepine was carried out by melting point and IR. Carbamazepine has limited aqueous solubility so in literature Self microemulsifying drug delivery system (SMEDDS) have been reported. In the present study, a topical microemulsion based gel of Carbamazepine was prepared. The pseudo ternary phase diagram was prepared to find the microemulsion region. Various microemulsion gel formulations were prepared using carbopol-974 and poloxamer-407 in varied concentrations. Prepared formulations (FG1 to FG10) were evaluated for various parameters like color, appearance, consistency, pH, spreadability and IR. The microemulsion based gels were found to have good
spreadability and pH within the range of skin pH and thus suitable to use on skin.
Formulation and Evaluation of Galantamine Hydrobromide Floating Matrix Tablet
Authors: Reddy Poreddy Srikanth , Bose Penjuri Subhash Chandra , Sruthi Vuppula , Saritha Damineni
Published: November 2018

The aim of the present work was to prepare floating tablets of galantamine HBr using sodium alginate and xanthan gum as matrix forming carriers. Galantamine HBr is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. The matrix tablet formulations were prepared by varying the concentrations of sodium alginate and xanthan gum. The tablets were prepared by direct compression technique using
PVP K-30 as a binder and sodium bicarbonate for development of CO2. The prepared matrix tablets were evaluated for properties such as hardness, thickness, friability, weight variation, floating lag time, compatibility using DSC and FTIR. In vitro dissolution was carried out for 12 hrs in 0.1N HCl at 37±0.5 ºC using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium by maintaining the matrix integrity. The drug release from prepared tablets was found to vary with varying concentration of the polymers, sodium alginate and xanthan gum. From the study it was concluded that floating drug delivery system for galantamine HBr can be prepared by using sodium alginate and xanthan gum as a carrier.
Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsion Delivery System Using Virgin Cocunut Oil (Vco)
Authors: M Tristiana Erawati , Soeratri Widji , Rosita Noorma
Published: November 2018

Ubiquinone (co-Q10) is a topical anti-aging with low solubility in water, so its penetration into the skin is also low. To increase its penetration ubiquinone (co-Q10) was loaded in the nanoemulsion delivery system using virgin coconut oil (VCO) as oil phase. Ubiquinone (co-Q10) in nanoemulsion formula consists of; ubiquinone (co-Q10), Tween 80, Span 80, ethanol 96%, VCO and acetate buffer solution pH 4.2 ± 0.5 with concentration; 1%; 18.66%; 1.92%; 3.42%; up to 100%, respectively. The characteristics of ubiquinone (co-Q10) nanoemulsion were observed in terms of droplet morphology by transmission electron microscope (TEM) and droplet size by particle analyzer, the pH and viscosity value. The ubiquinone (co-Q10) penetration test in the nanoemulsion system was compared with the emulsion on the rat skin. Result of this research showed the droplet morphology of ubiquinone (co-Q10) in nanoemulsion was spherical. The droplet size was 93.2 ± 2.78 nm. The pH value was 4.12 ± 0.02, and the viscosity was 8.5 cPas. Penetrasi of ubiquinone (co-Q10) in nanoemulsion was deeper (269 ± 48.12 and 993 ± 36.49 μm) than in emulsion (26.33 ± 6.43 and 110.33 ± 9.124 μm), after 2 and 6 hours sample application.
Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo
Authors: Stenton Benjamin , Oliveira Bruno , Conde João , Negrão Magda , Godinho Ferreira Miguel , Fior Rita , Bernardes Gonçalo
Published: November 2018

Creating ways to control drug activation at specific tissues while sparing healthy tissues remains a major challenge. The administration of exogenous triggers offers the possibility for precise and traceless drug activation. However, ensuring localization of the trigger as well as the prodrug at the diseased tissue is complex while essential for therapeutic efficacy and to avoid side-toxicity. Cisplatin remains a first line option to treat 20% of all cancer patients and while clearing after 30 min from blood it concentrates in tumor tissues. Here, we demonstrate the use of the platinum-mediated bond cleavage of protected tertiary amides, which can occur in a catalytic manner under bioorthogonal conditions. Protected analogues of cytotoxic drugs 5-fluorouracil (5-FU) and monomethyl auristatin E (MMAE) were successfully activated using non-toxic amounts of platinum salts in cells. An otherwise fully stable and non-internalizing ADC built using a bifunctional linker featuring a tertiary amide protected MMAE was also bioorthogonally decaged in the presence of platinum salts for extracellular drug release. Finally, cisplatin-mediated activation of a prodrug 5-FU was shown in a colorectal zebrafish xenograft model leading to a significant tumor reduction. Considering cisplatin’s continued use as a first-choice treatment for many solid cancers and especially in colorectal cancer, we anticipate that our platinum-mediated decaging strategy will enhance cancer therapy by allowing tumor specific prodrug activation.
A Mucin-Specific Protease Enables Molecular and Functional Analysis of Human Cancer-Associated Mucins
Authors: Malaker Stacy , Pedram Kayvon , Ferracane Michael J. , Woods Elliot C. , Kramer Jessica , Dorigo Oliver , Bertozzi Carolyn
Published: November 2018

Mucins are a class of highly O-glycosylated proteins that are ubiquitously expressed on cellular surfaces and are important for human health, especially in the context of carcinomas. However, the molecular mechanisms by which aberrant mucin structures lead to tumor progression and immune evasion have been slow to come to light, in part because methods for selective mucin degradation are lacking. Here we employ high resolution mass spectrometry, polymer synthesis, and computational peptide docking to demonstrate that a bacterial protease, called StcE, cleaves mucin domains by recognizing a discrete peptide-, glycan-, and secondary structure- based motif. We exploited StcE’s unique properties to map glycosylation sites and structures of purified and recombinant human mucins by mass spectrometry. As well, we found that StcE will digest cancer-associated mucins from cultured cells and from ovarian cancer patient-derived ascites fluid. Finally, using StcE we discovered that Siglec-7, a glyco-immune checkpoint receptor, specifically binds sialomucins as biological ligands, whereas the related Siglec-9 receptor does not. Mucin-specific proteolysis, as exemplified by StcE, is therefore a powerful tool for the study of glycoprotein structure and function and for deorphanizing mucin-binding receptors.
DFT calculation, molecular docking, biological activity and crystal structure of (E)-2-((4-tert-butylbenzylimino)methyl)-4-methoxyphenol
Authors: Zeyrek C.T. , Tümer Y. , Kiraz A. , Demir N. , Yapar G. , Boyacioğlu B. , Yıldız M. , Ünver H. , Elmali A.
Published: November 2018

(E)-2-((4-tert-butylbenzylimino)methyl)-4-methoxyphenol is synthesized by the reaction of 4-tert-buthylbenzylamine with 5-methoxysalicylaldehyde. The structure of the Schiff base is investigated by FT-IR, UV-visible, and 1H NMR, 13C NMR, and X-ray data. Moreover, the molecular structure, molecular electrostatic potential surfaces (MEP), frontier molecular orbitals, and nonlinear optical properties (NLO) are also investigated by density functional theory (DFT) calculations. The experimental and calculated results show that the phenol-imine form of the compound is more favoured than the keto-amine form. The most energy favourable docked structures are obtained from the rigid molecular docking of the compound with DNA. The compound binds at the active site of DNA proteins by weak non-covalent interactions. UV—Vis spectroscopy studies of the interactions between the compounds and calf thymus DNA (CT-DNA) show that the compounds interact with CT-DNA via the electrostatic and intercalative binding. The compound inhibits the frameshift and base pair mutations in the absence of S9 mix with a high inhibition rate. Also, the molecular docking is made to identify the interaction between the ligand and DNA.
Тетрагональный стехиометричный диселенид иттрия
Authors: Подберезская Н.В. , Комаров В.Ю. , Николаев Р.Е. , Чусова Т.П. , Зеленина Л.Н. , Кучумов Б.М. , Корольков И.В.
Published: November 2018

Методами порошковой ренгенографии, энергодисперсионной микроскопии, КР спектроскопии и рентгеноструктурного анализа исследована побочная фаза, полученная при синтезе полуторного селенида иттрия. Результаты микро- и спектроскопического методов показывают, что состав кристаллов близок по соотношению компонентов Y:Se ~1:2, причем характер КР спектра достаточно уверенно свидетельствует о стехиометрическом составе исследованного кристалла. Положения сильных дифракционных отражений, полученных от монокристалла, индицируются в элементарной ячейке с параметрами a = 4.0132(6), b = 4.0061(6), c = 8.2576(19) Å, симметрию которой в пределах систематической ошибки метода можно считать тетрагональной. Экспериментальный материал для рентгеноструктурного анализа (РСА) получен на автоматическом дифрактометре Bruker DUO с использованием MoKα-излучения. Средняя структура определена в тетрагональной сингонии (пр. гр. P4/nmm, a = 4.0141(6), c = 8.267(2) Å, V = 133.21(4) Å3). На экспериментальных фреймах наблюдаются слабые сверхструктурные пики, свидетельствующие о возможном увеличении параметров элементарной ячейки в соответствии с матрицей 4 0 0/0 3 0/0 0 2 и сохранении характера модуляции структуры, описанной для нестехиометрического образца YSe2–x (x = 0.15).
Crystal structure and thermoanalytical study of neodymium(III) complex with 2,4'-bipyridyne
Authors: Sieroń L. , Czylkowska A. , Raducka A.
Published: November 2018

A novel neodymium(III) chloride complex with 2,4'-bipyridine (bpy), (bpyH)[Nd(H2O)9]Cl4·bpy·H2O, has been synthesized, crystallized and characterized by single-crystal X-ray diffraction and thermal analysis. The crystal is nine-coordinate homoleptic mononuclear aqua-complex and crystallizes in the triclinic P-1 space group with two formula units in the unit cell related by a pseudo-translation of b/2. In the crystal structure, each [Nd(H2O)9]3+ ion is hydrogen-bonded in the same way to one 2,4'-bipyridine molecule, one 2,4-bipyridinium cation, and chloride anions. Lattice water molecules form hydrogen-bonds which further stabilize the framework. The thermal properties of compound in the solid state were studied using TG-DTG techniques under dynamic flowing air atmosphere.
Geometry, tautomerism and non-covalent interaction of bentiromide with a carbon-nanotube and γ-Fe2O3 nanoparticles: A quantum mechanical study
Authors: Tanhaei R. , Beyramabadi S.A. , Behmadi H.
Published: November 2018

A doctor can find out how pancreas is working using bentiromide. This drug can exist as six possible tautomers. Herein, by density functional theory (DFT) and handling the solvent effects with the polarizable continuum model (PCM), the mechanism of its tautomerization, energies, and structural parameters of the tautomers are investigated. Also, the natural bond orbital analysis (NBO) is used for exploring the frontier molecular orbitals. The most stable tautomer of bentiromide has three carbonyl groups in its structure. The amount of other tautomers is negligible in the aqueous solution. The non-covalent interactions of the most stable tautomer of bentiromide with an armchair (5,5) single-wall carbon nanotube and a γ-Fe2O3 nanoparticle are explored. In each case, three possible forms are optimized. Their most stable form is determined. The intermolecular H bonds have a critical role in the energy behavior of the interaction between bentiromide and the γ-Fe2O3 nanoparticle.
DO LABORATÓRIO AO SISTEMA DE LABORATÓRIO: A PRODUÇÃO SOCIAL HUMANA NO SÉCULO XX-XXI E SUA POSSIBILIDADE INVESTIGATIVA NA EDUCAÇÃO
Authors: Campana Samya
Published: November 2018

Baseados numa leitura crítica do modo como os homens transformam a realidade - pela união dos homens para reproduzir e produzir os meios de produção e suas vidas a partir de condições já existentes - discorremos sobre a ontologia da produção da ciência no século XX-XXI e sobre sua possibilidade investigativa na Educação entendendo-a como expressão orgânica (contraditória e em movimento) da superação das condições burguesas atualmente postas. Nosso ponto de partida e ao mesmo tempo resultado (item 1- “O sistema de laboratório: em busca da transcendência da sociabilidade da união entre os homens”) é o que se convencionou chamar de nanociência, adotando como pressuposto dessa produção a criação dos homens que nos precederam na forma da grande indústria moderna do século XIX, despojando-a de seu caráter natural e submetendo-a ao poder dos indivíduos unidos, os quais explicitam e desenvolvem a constituição do ser social. Na segunda parte deste artigo (item 2 – “Possibilidade de investigação na Educação no século XXI”) formulamos uma questão de pesquisa para a Educação problematizando sua relação com essa nova forma produtiva laboratorial como afirmação, negação e superação da relação social burguesa de produção.
DOS PROGRAMAS OFICIAIS PARA A EDUCAÇÃO RURAL AOS PROJETOS DE EDUCAÇÃO DO CAMPO DOS MOVIMENTOS SOCIAIS
Authors: Oliveira Mara Rita Duarte de
Published: November 2018

O presente trabalho tem como objetivo central discutir os programas oficiais destinados à educação das populações do campo, fazendo uma incursão dos anos 1930 até os anos de 1990. Apontando nesse percurso o surgimento das experiências de propostas educativas dos Movimentos sociais ligados à luta pela terra, em especial, dos Movimentos dos Trabalhadores Rurais (MST) e da Federação dos Trabalhadores da Agricultura (FRETAGRI), tais propostas desenvolvidas no Estado do Pará, são experiências de resistência às propostas oficiais homogenizadoras que deslegitimam e aviltam a identidade camponesa. Ainda, no campo das experiências educativas dos movimentos sociais aponta o caráter emancipador de tais propostas e a contribuição dessas para novos itinerários educativo da educação campo.
PRIVATIZAÇÃO DO SETOR ELÉTRICO BRASILEIRO: IMPACTOS SOBRE O TRABALHO
Authors: Etcheverry Maria Soledad
Published: November 2018

Com a privatização de grandes empresas que compunham o sistema elétrico brasileiro, ao longo da década de noventa, opera-se uma mudança radical no setor, pautada sobre uma nova concepção da energia elétrica. Passava-se de uma visão que considerava a energia como bem social, supostamente presente na ótica de um serviço estatal cooperativo, para outra, que transformava a energia em uma mercadoria, dependente das oscilações da oferta e demanda, comandada pela ótica do lucro.  A partir de 2002, são introduzidas novas modificações no modelo do setor elétrico, visando equacionar o fracasso do processo de privatização que apostou na auto-regulação do setor pelo mercado e que tinha culminado na crise nacional do “Apagão” no ano anterior.  Essas medidas, que a partir desse momento procuram gradativamente viabilizar um sistema misto, de base estatal e privada, recebem novo alento a partir do governo Lula, coroando um processo de transformações desde a década de noventa e gerando impactos significativos sobre o mundo do trabalho no setor.
TRABALHO E MODO DE VIDA: A EXPERIÊNCIA DOS OPERÁRIOS EM NOVAS ÁREAS INDUSTRIAIS
Authors: Borsoi Izabel Cristina Ferreira
Published: November 2018

O Nordeste tem sido um grande atrativo para fábricas, oriundas das regiões Sul e Sudeste, que buscam condições favoráveis à sua expansão — no caso, incentivos fiscais, infra-estrutura e força de trabalho de baixo custo. No Ceará, esse processo tem sido crescente principalmente a partir do início dos anos de 1990. O objetivo deste trabalho é discutir alguns aspectos do modo de vida de trabalhadores de fábricas instaladas em um município cearense que se desenvolveu a partir de um processo de industrialização favorecido pelas políticas do governo estadual. A discussão é fundamentada em um conjunto de entrevistas com trabalhadores e ex-trabalhadores de cinco dessas fábricas. Do que se pôde concluir, por um lado, os trabalhadores estão sendo submetidos a ritmos intensos, jornadas extensas e condições inadequadas de trabalho. Por outro, eles vêm construindo um novo modo de organizar a vida fora do trabalho, em função tanto do que vêm aprendendo quanto do que lhes têm sido exigido nas dependências das fábricas onde trabalham. Entre outros aspectos, o conjunto de mudanças tem envolvido hábitos, valores e relações familiares e afetivas.
CONHECENDO E AFERINDO: BOURDIEU E O ‘SER ENGENHEIRO’
Authors: Sapunara Raquel Anna , Souza Adrielle Reis de
Published: November 2018

O filósofo e sociólogo Pierre Bourdieu desenvolveu a ideia de campo científico, a partir do antagonismo existente entre as interpretações das produções com pretensões científicas, para explicar as relações de poder existentes em qualquer área de estudo. Nesse contexto, o presente artigo posiciona o engenheiro como agente social no campo, discutindo este conceito conjuntamente com os conceitos de capital puro e capital institucional e espaço social, além de estabelecer a ideia do ‘ser engenheiro’. Para tal, utilizamos o livro Os usos sociais da ciência: por uma sociologia clínica do campo científico como fonte primária principal.
FAMÍLIA E ESCOLA: UM NOVO (RE) PENSAR E (RE) AGIR PEDAGÓGICO
Authors: Oliveira Junior Isaias Batista de , Maio Eliane Rose
Published: November 2018

Este artigo tem como propósito demonstrar a involução da escola ao adotar um modelo único de família, do qual se distancia a grande maioria. A escola ao conceber o papel de desenvolver o conhecimento busca dividir a tarefa com as famílias tentando integrá-las ao âmbito escolar como coadjuvantes do processo de ensino-aprendizagem. Porém as mudanças ocorridas nas últimas décadas do século XX têm dado novos contornos aos núcleos familiares e o que se observa na maioria das vezes é que o sistema educacional desconhece, ignora ou culpa os novos arranjos familiares pelo “sucesso” ou “fracasso escolar” de seus alunos. Considerações essas que tem despertado o interesse de teóricos em estudar as famílias, buscando identificá-las, de modo que essas características inflijam à escola maior precaução quando se tratar de afirmações taxativas sobre a normatividade das famílias em seus ritos escolares. As considerações finais do referido estudo apontam que investir em capacitação da comunidade escolar, bem como uma reestruturação curricular, são necessárias, objetivando a ética, o respeito à diversidade e o acolhimento dos sujeitos oriundos dessas novas configurações familiares.
O IDEÁRIO LIBERAL NAS REFORMAS EDUCACIONAIS BRASILEIRA ENTRE 1920 E 1940
Authors: Zanlorense Maria Joselia , Santos Almir Paulo dos
Published: November 2018

Neste texto discute-se as reformas educacionais as quais direcionaram a educação profissional no Brasil entre 1920 a 1940, momento que aconteceram os movimentos que visaram discutia educação brasileira culminando nas reformas educacionais as quais direcionaram a formação do trabalhador, mantendo a dualidade de ensino. Pondera-se neste estudo o ideário liberal e conservador na educação, a influência do ideário da Escola Nova e seus defensores no Brasil. A Reforma Francisco Campos que proporcionou mudanças no ensino comercial e superior; a criação do Instituto de Organização e Racional do Trabalho – IDOTR que buscou a organização no espaço das fábricas e o controle do trabalhador atendendo os ditames do capital. Apresenta-se a instauração do Estado Novo e a ratificação da educação profissional direcionada aos menos favorecidos economicamente pela Constituição Federal de 1937. Na década de 1940 ocorreram novas reformas educacionais denominadas de Leis Orgânicas do Ensino as quais, em tempos conservadores, consolidaram a dualidade de ensino com princípios liberais proporcionando à elite o acesso à formação clássica humanística e o ensino profissional direcionado à classe trabalhadora.
MERITOCRACIA ESCOLAR E EDUCAÇAO PROFISSIONAL: UM ESTUDO SOBRE O PRONATEC
Authors: Cruz Keyla De Souza Lima , Carneiro Isabel Magda Said Pierre , Arrais Neto Enéas De Araújo
Published: November 2018

Este trabalho analisa até que ponto o Programa Nacional de Acesso ao Ensino Técnico e Emprego (PRONATEC) tem contribuído para ampliar o acesso à educação profissional de jovens e trabalhadores. Para tanto, realizamos uma análise desse programa no contexto atual de expansão da Rede Federal de Educação profissional, problematizando a relação da gestão do programa com o discurso meritocrático de ascensão e sucesso profissional. Inserida numa abordagem qualitativa de pesquisa, o estudo classifica-se como um estudo de caso numa instituição pública federal de educação profissional. Como procedimento de coleta de dados, realizamos entrevistas semiestruturadas com os profissionais gestores do referido programa: o coordenador geral e o coordenador adjunto. Dentre os resultados destacamos o acesso de jovens e trabalhadores à educação profissional por meio dos cursos de formação inicial e continuada (FIC’s) e dos cursos técnicos, contudo a pesquisa revela o interesse político atual a nível nacional e local de ofertar cursos FIC’s em detrimento dos cursos técnicos integrados. As principais razões apontadas pelos gestores foram: não possuírem uma estrutura de laboratórios e de recursos humanos suficientes para suprir as necessidades dos cursos técnicos, além de sinalizarem que o público-alvo deste programa não estaria “muito bem preparado”, ressaltando a existência de altos índices de evasão. Ademais os sujeitos da pesquisa apontaram as dificuldades de acompanhamento dos jovens nos cursos, em decorrência das lacunas educacionais, especialmente, no que diz respeito aos conhecimentos nas áreas de exatas. Apesar das limitações da escola na formação profissional, é inegável o valor do "certificado escolar", que abre as portas para o exercício das funções intelectuais.