bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-crown restorations supported by short implants (6 mm) compared with standard-length implants (13 mm) in conjunction with maxillary sinus floor augmentation: a randomized, controlled clinical trial
Authors: Nielsen Helle Baungaard , Schou Søren , Bruun Niels Henrik , Starch-Jensen Thomas
Published: July 2021

Background

The purpose of the present study was to test the H0-hypothesis of no difference in the clinical and radiographical treatment outcome of single-crown restorations supported by short implants compared with standard length implants in conjunction with maxillary sinus floor augmentation (MSFA) after 1 year of functional implant loading. Forty patients with partial edentulism in the posterior part of the maxilla were randomly allocated to treatment involving single-crown restorations supported by short implants or standard length implants in conjunction with MSFA. Clinical and radiographical evaluation were used to assess survival of suprastructures and implants, peri-implant marginal bone loss (PIMBL), biological, and mechanical complications.

Results

Both treatment modalities were characterized by 100% survival of suprastructures and implants after 1 year. Mean PIMBL was 0.60 mm with short implants compared with 0.51 mm with standard length implants after 1 year of functional loading. There were no statistically significant differences in survival of suprastructure and implants, PIMBL, and mechanical complications between the two treatment modalities. However, a higher incidence of biological complications was associated with standard length implants in conjunction with MSFA.

Conclusion

Within the limitations of the present study, it can be concluded that single-crown restorations supported by short implants seems to be comparable with standard length implants in conjunction with MSFA. However, long-term studies are needed before final conclusions can be provided about the two treatment modalities.

Trial registration

Clinicaltrials.Gov ID: NCT04518020. Date of registration: August 14, 2020, retrospectively registered.
Incidence and determinants of perinatal mortality among women with obstructed labour in eastern Uganda: a prospective cohort study
Authors: Musaba Milton W. , Ndeezi Grace , Barageine Justus K. , Weeks Andrew D. , Wandabwa Julius N. , Mukunya David , Waako Paul , Odongkara Beatrice , Arach Agnes , Tulya-muhika Mugabe Kenneth , Kasede Napyo Agnes , Nankabirwa Victoria , Tumwine James K.
Published: July 2021

Background

In Uganda, the incidence and determinants of perinatal death in obstructed labour are not well documented. We determined the incidence and determinants of perinatal mortality among women with obstructed labour in Eastern Uganda.

Methods

Between July 2018 and September 2019, 584 with obstructed labour were recruited and followed up to the 7th day postnatal. Information on maternal characteristics, obstetric factors and laboratory parameters was collected. Each patient received the standard perioperative care. We used a generalized linear model for the Poisson family, with a log link and robust variance estimation to determine the association between the exposure variables and perinatal death.

Results

Of the 623 women diagnosed with obstructed labour, 584 met the eligibility criteria. There were 24 fresh still births (FSB) and 32 early neonatal deaths (ENND) giving an FSB rate of 43.8 (95% CI 28.3–64.4) deaths per 1000 total births; early neonatal death rate of 58.4 (95% CI 40.3–81.4) deaths per 1000 and an overall perinatal mortality rate of 102.2 (95% CI 79.4–130.6) deaths in the first 7 days of life. A mother being referred in active labour adjusted risk ratio of 2.84 (95% CI: 1.35–5.96) and having high blood lactate levels at recruitment adjusted risk ratio 2.71 (95% CI: 1.26–4.24) were the determinants of perinatal deaths.

Conclusions

The incidence of perinatal death was four times the regional and national average. Babies to women referred in active labour and those with high maternal blood lactate were more likely to die.
Immune-mediated inflammatory diseases and nutrition: results from an online survey on patients’ practices and perceptions
Authors: Pham Thao , Sokol Harry , Halioua Bruno , Pourcel Graziella , Brun Manuel , Pain Emilie , Testa Damien
Published: July 2021

Background

The central role of microbiota and the contribution of diet in immune-mediated inflammatory diseases (IMID) are increasingly examined. However, patients’ perspectives on nutrition and its impact on their disease has not received a lot of attention. We aimed to directly collect information from patients with IMID about their dietary behaviors and their perceptions of the influence of nutrition on their disease.

Methods

Adult patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn’s disease, ulcerative colitis or psoriasis registered in an online patient community were invited to participate in the study and complete an online self-administered questionnaire. We assessed patients’ dietary knowledge and choices by collecting information on the diet regimens they were following or recommended and their perceptions of the diet and its consequences on their disease.

Results

Fifty patients per target disease were included with a mean age of 48.1 years (95%CI 46.7–49.6). Other sociodemographic and clinical characteristics varied across the diseases. Since diagnosis, 44% of the patients changed their eating habits, mainly patients with inflammatory bowel disease with 69% of these making the change on their own initiative. Patients who did not change their diet habits reported not having received nutritional advice from their healthcare professionals (HCP) in 69% of the cases. The perceived impact of nutrition on their symptoms was mixed (overall 74% of the patients reported positive consequences and 60% negative ones) and varied across the diseases. Patients with psoriasis only experienced positive consequences from changing their diet, such as reduction of stress and improved mental health, while patients with Crohn’s disease reported more negative effects such as increased fatigue and disturbed sleep. Patients with rheumatic diseases and ulcerative colitis reported weight loss and better physical fitness, but also increased fatigue.

Conclusions

Even if differences exist across diseases, the importance of nutrition and its potential positive role in symptom management is acknowledged by the majority of the patients. However, there is a need and a demand from patients to receive more dietary advice. Developing therapeutic education tools on nutrition for people with IMID and involving patients’ organizations would provide useful information and encourage communication between HCP and patients.
Towards attaining the recommended Humanitarian Sphere Standards of sanitation in Bidibidi refugee camp found in Yumbe District, Uganda
Authors: Bako Zaitun , Barakagira Alex , Nabukonde Ameria
Published: July 2021

Adequate sanitation is one of the most important aspects of community well-being. It reduces the rates of morbidity and severity of various diseases like diarrhea, dysentery, and typhoid among others. A study about toward the attainment of the recommended Humanitarian Sphere Standards on sanitation in Bidibidi refugee camp, Yumbe District, was initiated. A total of 210 households distributed in Bidibidi refugee camp were randomly selected and one adult person interviewed to assess the accessibility of different sanitation facilities, and to explore the sanitation standards of the sanitation facilities in relation to the recommended Humanitarian Sphere Standards in the area. Pit latrines, hand washing facilities, and solid waste disposal areas as reported by 81.4%, 86.7%, and 51.9% of the respondents respectively, are the main sanitation facilities accessed in the refugee camp. Despite their accessibility, the standards of the pit latrines, hand washing, and solid waste disposal facilities are below the recommended standards, which might have contributed to the outbreak of sanitation related diseases (χ2 = 19.66, df = 1, P = 0.05) in Bidibidi refugee camp. The respondents in the study area were aware that the presence of the sanitation-related diseases was because of the low-level sanitation practices in place (χ2 = 4.54, df = 1, P = 0.05). The inaccessibility to some sanitation facilities by some respondents was found to be related to their low level of education (χ2 = 130.37, df = 1, P = 0.05). This implies that the sanitation facilities in Bidibidi refugee camp need to be redesigned and improved especially the pit latrines and the solid waste disposal facilities in order to meet the minimum Humanitarian Sphere Standards. Also, there should be more provision of taps with flowing water in the camp for effective washing practices to minimize the spread of sanitation-related diseases.
A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function
Authors: Garcia-Varela Lara , Attia Khaled , Sembrano John Carlo , Jacquet Olivier , Antunes Inês F. , Kwizera Chantal , Visser Ton J. , Dierckx Rudi A. J. O. , Elsinga Philip H. , Luurtsema Gert
Published: July 2021

Background

[18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been described in patients with Alzheimer’s or Parkinson’s Disease. The current applied radiosynthesis of [18F]MC225 involves 2 steps, including the distillation of the [18F] fluoroethylbromide intermediate. To develop a more robust synthetic procedure, it is of interest to produce the radiotracer via a 1-step synthesis. The present study describes a new synthetic approach to produce [18F]MC225 via direct 18F-fluorination. Moreover, we also provide the appropriate conditions for the automation of the synthesis. A mesylate precursor was synthesized via a multi-step synthetic route and used for the radiolabeling. The nucleophilic substitution of the mesylate group by [18F] Fluoride was automated in two different synthesis modules: IBA Synthera and Eckert and Ziegler PharmTracer (E&Z).

Results

The mesylate precursor was synthesized in 7 steps starting with 5-hydroxy-1-tetralone (commercially available) in practical yields. The stability of the precursor was improved via mesylate salt formation method. The radiolabeling was done by adding the mesylate precursor dissolved in DMF to the dried [18F]KF/K2.2.2 complex and heating at 140 °C for 30 min. Quality control by UPLC confirmed the production of [18F]MC225 with a molar activity (Am) higher than 100 GBq/micromole. The synthesis time in Synthera was 106 min and the product was obtained with a radiochemical purity higher than 95% and RCY of 6.5%, while the production in E&Z lasted 120 min and the product had a lower radiochemical purity (91%) and RCY (3.8%).

Conclusions

[18F]MC225 was successfully produced via a 1-step reaction. The procedure is suitable for automation using commercially available synthesis modules. The automation of the radiosynthesis in the Synthera module allows the production of the [18F]MC225 by a reliable and simple method.
Isolation and efficacy of two bacterial strains antagonists of Erwinia amylovora and Pectobacterium carotovorum
Authors: BENADA M’hamed , BOUMAAZA Boualem , BOUDALIA Sofiane , KHALADI Omar
Published: July 2021

Background

The development of ecofriendly tools against plant diseases is an important issue in crop protection. Screening and selection process of bacterial strains antagonists of 2 pathogenic bacterial species that limit very important crops, Erwinia amylovora, the causal agent of the fire blight disease, and Pectobacterium carotovorum, the causal agent of bacterial potato soft rot, were reported. Bacterial colonies were isolated from different ecological niches, where both pathogens were found: rhizosphere of potato tubers and fruits and leaves of pear trees from the northwest region of Algeria. Direct and indirect confrontation tests against strains of E. amylovora and P. carotovorum were performed.

Results

Results showed a significant antagonistic activity against both phytopathogenic species, using direct confrontation method and supernatants of cultures (p<0.005). In vitro assays showed growth inhibitions of both phytopathogenic species. Furthermore, results revealed that the strains of S. plymuthica had a better inhibitory effect than the strains of P. fluorescens against both pathogens. In vivo results on immature pear fruits showed a significant decrease in the progression of the fire blight symptoms, with a variation in the infection index from one antagonistic strain to another between 31.3 and 50%, and slice of potato showed total inhibition of the pathogen (P. carotovorum) by the antagonistic strains of Serratia plymuthica (p<0.005).

Conclusion

This study highlighted that the effective bacteria did not show any infection signs towards plant tissue, and considered as a potential strategy to limit the fire blight and soft rot diseases.
Aflatoxin contamination in food crops: causes, detection, and management: a review
Authors: Kumar Abhishek , Pathak Hardik , Bhadauria Seema , Sudan Jebi
Published: July 2021

Mycotoxins are secondary metabolites produced by several fungal species and molds. Under favorable conditions like high temperature and moisture, they contaminate a large number of food commodities and regional crops during pre and post-harvesting. Aflatoxin is the main mycotoxin that harm animal and human health due to its carcinogenic nature. Aflatoxins are mainly released by Aspergillus flavus and Aspergillus parasiticus. AFB1 constitutes the most harmful type of aflatoxins and is a potent hepato-carcinogenic, mutagenic, teratogenic and it suppresses the immune system. To maintain food safety and to prevent aflatoxin contamination in food crops, combined approaches of using resistant varieties along with recommended farming practices should be followed. This review concentrates on various aspects of mycotoxin contamination in crops and recent methods to prevent or minimize the contamination.
Second-order implicit finite-difference schemes for the acoustic wave equation in the time-space domain
Authors: Amini Navid , Shin Changsoo , Lee Jaejoon
Published: July 2021

We have developed compact implicit finite-difference (FD) schemes in the time-space domain based on the second-order FD approximation for accurate solution of the acoustic wave equation in 1D, 2D, and 3D. Our method is based on the weighted linear combination of the second-order FD operators with different spatial orientations to mitigate numerical error anisotropy and the weighted averaging of the mass acceleration term over the grid points of the second-order FD stencil to reduce the overall numerical dispersion error. We have developed a derivation of the schemes for 1D, 2D, and 3D cases. We obtain their corresponding dispersion equations, then we find the optimum weights by optimization of the time-space domain dispersion function, and finally we tabulate the optimized weights for each case. We analyze the numerical dispersion, stability, and convergence rates of our schemes and compare their numerical dispersion characteristics with the standard high-order ones. We also discuss the efficient solution of the system of equations associated with our implicit schemes using the conjugate-gradient method. The comparison of dispersion curves and the numerical solutions with the analytical and the pseudospectral solutions reveals that our schemes have better performance than the standard spatial high-order schemes and remain stable for relatively large time steps.
Phase II Randomized Study of CMB305 and Atezolizumab Compared With Atezolizumab Alone in Soft-Tissue Sarcomas Expressing NY-ESO-1
Authors: Chawla Sant P. , Van Tine Brian A. , Pollack Seth M. , Ganjoo Kristen N. , Elias Anthony D. , Riedel Richard F. , Attia Steven , Choy Edwin , Okuno Scott H. , Agulnik Mark , von Mehren Margaret , Livingston Michael B. , Keedy Vicki L. , Verschraegen Claire F. , Philip Tony , Bohac G. Chet , Yurasov Sergey , Yakovich Adam , Lu Hailing , Chen Michael , Maki Robert G.
Published: July 2021

PURPOSE

CMB305 is a heterologous prime-boost vaccination regimen created to prime NY-ESO-1–specific CD8 T-cell populations and then activate the immune response with a potent TLR-4 agonist. This open-label randomized phase II trial was designed to investigate the efficacy and safety of adding the CMB305 regimen to atezolizumab (anti–programmed death ligand-1 therapy) in comparison with atezolizumab alone in patients with synovial sarcoma or myxoid liposarcoma.

PATIENTS AND METHODS

Patients with locally advanced, relapsed, or metastatic synovial sarcoma or myxoid liposarcoma (any grade) were randomly assigned to receive CMB305 with atezolizumab (experimental arm) or atezolizumab alone (control arm). The primary end points were progression-free survival (PFS) and overall survival (OS) analyzed using the Kaplan-Meier method. Safety and immune responses were assessed.

RESULTS

A total of 89 patients were enrolled; 55.1% had received ≥ 2 prior lines of chemotherapy. Median PFS was 2.6 months and 1.6 months in the combination and control arms, respectively (hazard ratio, 0.9; 95% CI, 0.6 to 1.3). Median OS was 18 months in both treatment arms. Patients treated with combination therapy had a significantly higher rate of treatment-induced NY-ESO-1–specific T cells ( P = .01) and NY-ESO-1–specific antibody responses ( P < .0001). In a post hoc analysis of all dosed patients, OS was longer (36 months) in the subset who developed anti-NY-ESO-1 T-cell immune response (hazard ratio, 0.3; P = .02).

CONCLUSION

Although the combination of CMB305 and atezolizumab did not result in significant increases in PFS or OS compared with atezolizumab alone, some patients demonstrated evidence of an anti-NY-ESO-1 immune response and appeared to fare better by imaging than those without such an immune response. Combining prime-boost vaccines such as CMB305 with anti–programmed death ligand-1 therapies merits further evaluation in other clinical contexts.
Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults
Authors: Sigala Desiree M , Hieronimus Bettina , Medici Valentina , Lee Vivien , Nunez Marinelle V , Bremer Andrew A , Cox Chad L , Price Candice A , Benyam Yanet , Chaudhari Abhijit J , Abdelhafez Yasser , McGahan John P , Goran Michael I , Sirlin Claude B , Pacini Giovanni , Tura Andrea , Keim Nancy L , Havel Peter J , Stanhope Kimber L
Published: July 2021

Context

Studies in rodents and humans suggest that high-fructose corn syrup (HFCS)–sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets.

Objective

To compare the effects of consuming sucrose-sweetened beverage (SB), HFCS-SB, or a control beverage sweetened with aspartame on metabolic outcomes in humans.

Methods

A parallel, double-blinded, NIH-funded study. Experimental procedures were conducted during 3.5 days of inpatient residence with controlled feeding at a research clinic before (baseline) and after a 12-day outpatient intervention period. Seventy-five adults (18-40 years) were assigned to beverage groups matched for sex, body mass index (18-35 kg/m2), and fasting triglyceride, lipoprotein and insulin concentrations. The intervention was 3 servings/day of sucrose- or HFCS-SB providing 25% of energy requirement or aspartame-SB, consumed for 16 days. Main outcome measures were %hepatic lipid, Matsuda insulin sensitivity index (ISI), and Predicted M ISI.

Results

Sucrose-SB increased %hepatic lipid (absolute change: 0.6 ± 0.2%) compared with aspartame-SB (-0.2 ± 0.2%, P < 0.05) and compared with baseline (P < 0.001). HFCS-SB increased %hepatic lipid compared with baseline (0.4 ± 0.2%, P < 0.05). Compared with aspartame-SB, Matsuda ISI decreased after consumption of HFCS- (P < 0.01) and sucrose-SB (P < 0.01), and Predicted M ISI decreased after consumption of HFCS-SB (P < 0.05). Sucrose- and HFCS-SB increased plasma concentrations of lipids, lipoproteins, and uric acid compared with aspartame-SB. No outcomes were differentially affected by sucrose- compared with HFCS-SB. Beverage group effects remained significant when analyses were adjusted for changes in body weight.

Conclusion

Consumption of both sucrose- and HFCS-SB induced detrimental changes in hepatic lipid, insulin sensitivity, and circulating lipids, lipoproteins and uric acid in 2 weeks.
Hormonally Regulated Myogenic miR-486 Influences Sex-specific Differences in Cancer-induced Skeletal Muscle Defects
Authors: Wang Ruizhong , Bhat-Nakshatri Poornima , Zhong Xiaoling , Zimmers Teresa , Nakshatri Harikrishna
Published: July 2021

Cancer-induced skeletal muscle defects show sex-specific differences in severity with men performing poorly compared to women. Hormones and sex chromosomal differences are suggested to mediate these differences, but the functional skeletal muscle markers to document these differences are unknown. We show that the myogenic microRNA miR-486 is a marker of sex-specific differences in cancer-induced skeletal muscle defects. Cancer-induced loss of circulating miR-486 was more severe in men with bladder, lung, and pancreatic cancers compared to women with the same cancer types. In a syngeneic model of pancreatic cancer, circulating and skeletal muscle loss of miR-486 was more severe in male mice compared to female mice. Estradiol (E2) and the clinically used selective estrogen receptor modulator toremifene increased miR-486 in undifferentiated and differentiated myoblast cell line C2C12 and E2-inducible expression correlated with direct binding of estrogen receptor alpha (ERα) to the regulatory region of the miR-486 gene. E2 and toremifene reduced the actions of cytokines such as myostatin, transforming growth factor β, and tumor necrosis factor α, which mediate cancer-induced skeletal muscle wasting. E2- and toremifene-treated C2C12 myoblast/myotube cells contained elevated levels of active protein kinase B (AKT) with a corresponding decrease in the levels of its negative regulator PTEN, which is a target of miR-486. We propose an ERα:E2-miR-486-AKT signaling axis, which reduces the deleterious effects of cancer-induced cytokines/chemokines on skeletal muscle mass and/or function.
Archiving Mexican Masculinities in Diaspora
Authors: Guidotti-Hernández Nicole M.
Published: July 2021

In Archiving Mexican Masculinities in Diaspora, Nicole M. Guidotti-Hernández challenges machismo—a shorthand for racialized and heteronormative Latinx men's misogyny—with nuanced portraits of Mexican men and masculinities along and across the US-Mexico border. Guidotti-Hernández foregrounds Mexican men's emotional vulnerabilities and intimacies in their diasporic communities. Highlighting how Enrique Flores Magón, an anarchist political leader and journalist, upended gender norms through sentimentality and emotional vulnerability that he performed publicly and expressed privately, Guidotti-Hernández documents compelling continuities between his expressions and those of men enrolled in the Bracero program. Braceros—more than 4.5 million Mexican men who traveled to the United States to work in temporary agricultural jobs from 1942 to 1964—forged domesticity and intimacy, sharing affection but also physical violence. Through these case studies that reexamine the diasporic male private sphere, Guidotti-Hernández formulates a theory of transnational Mexican masculinities rooted in emotional and physical intimacy that emerged from the experiences of being racial, political, and social outsiders in the United States.
Knowledge, attitude, and behavior of Turkish dentists about radiation protection and radiation safety
Authors: Yurt Ayşegül , Ayrancıoğlu Ceren , Kılınç Gülser , Ergönül Esin
Published: July 2021

Objectives:

Dentists use dental imaging methods frequently in the diagnosis and treatment of dental diseases. This study aimed to determine dentists' knowledge, attitudes, and behaviors about radiation protection during dental imaging procedures.

Methods:

Dentists from two major dental health centres in İzmir province were asked to participate in this study. The participants replied to a questionnaire that consisted of questions on the use of radiographic devices, knowledge on the radiation protection of patients and staff, and attitudes and behaviors regarding radiation protection. The questionnaire also included questions about the socio-demographic characteristics of the participants. Descriptive statistics of data were performed using the SPSS software program.

Results:

Sixty-six dentists participated in the survey. The mean knowledge score of dentists on dental imaging, radiation, and radiation protection was 8.3 ± 2.6 out of 17, while the mean attitude and behavior score was 8.3 ± 2.1 out of 27.97% of the participants stated that medical imaging technicians should carry out imaging procedures. The use of rectangular collimators was 9.1%, and using E/F film was 56.3% among dentists. 23.3% of participants stated that they applied the bisecting angle technique during dental imaging, 23.8% stated that they wear a lead apron during imaging, and 37.8% stated that they always used thyroid shields on the patients. In addition, 37.2% of the dentists stated that the patient holds the film during preapical radiography, and 81.5% used the same imaging parameters for adult and pediatric patients. 62% of dentists stated that they question the pregnancy of female patients before imaging.

Conclusion:

Findings of the study suggest that the knowledge of dentists about dental imaging procedures and radiation protection needs to be improved. The implementation and the follow-up of quality training programs in accordance with the standards set by the national authority will be of great importance.
Domino-style earthquakes along blind normal faults in Northern Thessaly (Greece): kinematic evidence from field observations, seismology, SAR interferometry and GNSS
Authors: Ganas Athanassios , Valkaniotis Sotiris , Briole Pierre , Serpetsidaki Anna , Kapetanidis Vassilis , Karasante Ilektra , Kassaras Ioannis , Papathanassiou George , Karamitros Ioannis , Tsironi Varvara , Elias Panagiotis , Sarhosis Vasilis , Karakonstantis Andreas , Konstantakopoulou Emmanouela , Papadimitriou Panagiotis , Sokos Efthimios
Published: July 2021

Here we present a joint analysis of the geodetic, seismological and geological data of the March 2021 Northern Thessaly seismic sequence, that were gathered and processed as of April 30, 2021. First, we relocated seismicity data from regional and local networks and inferred the dip-direction (NE) and dip-angle (38°) of the March 3, 2021 rupture plane. Furthermore, we used ascending and descending SAR images acquired by the Sentinel-1 satellites to map the co-seismic displacement field. Our results indicate that the March 3, 2021 Mw=6.3 rupture occurred on a NE-dipping, 39° normal fault located between the villages Zarko (Trikala) and Damasi (Larissa). The event of March 4, 2021 occurred northwest of Damasi, along a fault oriented WNW-ESE and produced less deformation than the event of the previous day. The third event occurred on March 12, 2021 along a south-dipping normal fault. We computed 22 focal mechanisms of aftershocks with M≥4.0 using P-wave first motion polarities. Nearly all focal mechanisms exhibit normal kinematics or have a dominant normal dip-slip component. The use of InSAR was crucial to differentiate the ground deformation between the ruptures. The majority of deformation occurs in the vertical component, with a maximum of 0.39 m of subsidence over the Mw=6.3 rupture plane, south and west of Damasi. A total amount of 0.3 m horizontal displacement (E-W) was measured. We also used GNSS data (at 30-s sampling interval) from twelve permanent stations near the epicentres to obtain 3D seismic offsets of station positions. Only the first event produces significant displacement at the GNSS stations (as predicted by the fault models, themselves very well constrained by InSAR). We calculated several post-seismic interferograms, yet we have observed that there is almost no post-seismic deformation, except in the footwall area (Zarkos mountain). This post-seismic deformation is below the 7 mm level (quarter of a fringe) in the near field and below the 1 mm level at the GNSS sites. The cascading activation of the three events in a SE to NW direction points to a pattern of domino-style earthquakes, along neighbouring fault segments. The kinematics of the ruptures point to a counter-clockwise change in the extension direction of the upper crust (from NE-SW near Damasi to N-S towards northwest, near Verdikoussa).
Case Report: Priapism as the clinical presentation of chronic myeloid leukemia in accordance with reports created during last twenty years: a case report and literature review
Authors: Bintoro Siprianus Ugroseno Yudho , Romadhon Pradana Zaky , Suryantoro Satriyo Dwi , Aminy Rusdi Zakki , Windradi Choirina , Widiyastuti Krisnina Nurul
Published: July 2021

Priapism in chronic myeloid leukemia (CML) appears to be an infrequent manifestation as well as a crucial emergency. Here, we report an 18-year-old male presenting with a persistent erection of penis for 20 days. We evaluate and compare the reported cases during the past 20 years discussing the management of CML patients experiencing priapism. Cytoreductive therapy followed by leukapheresis, the administration of tyrosine kinase inhibitor, and intra-cavernosal blood aspiration may resolve the symptoms of priapism. Early intervention for cytoreduction and aspiration are the pivotal keys to successfully impeding the complications.
Lateral versus posterior surgical approach for the treatment of supracondylar humeral fractures in children: a systematic review and meta-analysis
Authors: Irianto Komang Agung , Pradana I Putu Gede Pradnyadewa , De Vega Brigita
Published: July 2021

Background: Supracondylar humeral fracture (SHF) is the most common type of fracture in children. Moreover, lateral and posterior surgical approaches are the most frequently chosen approaches for open reduction surgery in displaced SHF when closed reduction fails. However, previous literature showed mixed findings regarding functional and cosmetic outcomes. Currently, no systematic review and meta-analysis has compared these two procedures. 

Methods: Our protocol was registered at PROSPERO (registration number CRD42021213763). We conducted a comprehensive electronic database search in MEDLINE, EMBASE, and CENTRAL. Two independent reviewers screened the title and abstract, followed by full-text reading and study selection based on eligibility criteria. The quality of the selected studies was analyzed with the ROBINS-I tool. Meta-analysis was carried out to compare the range of motion (functional outcome) and cosmetic outcome according to Flynn’s criteria. This systematic review was conducted based on PRISMA and Cochrane handbook guidelines. 

Results: Our initial search yielded 163 studies, from which we included five comparative studies comprising 231 children in the qualitative and quantitative analysis. The lateral approach was more likely to result in excellent (OR 1.69, 95% CI [0.97-2.93]) and good (OR 1.12, 95% CI [0.61-2.04]) functional outcomes and less likely to result in fair (OR 0.84, 95% CI [0.34-2.13]) and poor (OR 0.42, 95% CI [0.1-1.73]) functional outcomes compared to the posterior approach. In terms of cosmetic results, both approaches showed mixed findings. The lateral approach was more likely to result in excellent (OR 1.11, 95% CI [0.61-2.02]) and fair (OR 1.18, 95% CI [0.49-2.80]) but less likely to result in good (OR 0.79, 95% CI [0.40-1.55]) cosmetic outcomes. However, none of these analyses were statistically significant (p> 0.05). 

Conclusion: Lateral and posterior surgical approaches resulted in satisfactory functional and cosmetic outcomes. The two approaches are comparable for treating SHF in children when evaluated with Flynn’s criteria.
Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast
Authors: Marquez Johana , Marrugo Padilla Albeiro , Méndez Cuadro Darío , Rodríguez Cavallo Erika
Published: July 2021

Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs. However, during animal husbandry chickens are exposed to many chemical substances, including tetracyclines and β-lactams, which are used to prevent and cure several infections. Some residues of these compounds may bioaccumulate and be present in chicken meat after slaughtering, promoting oxidative reactions.

Methods: In order to evaluate in vitro carbonylation induced by tetracyclines and β-lactams residues, a proteomic approach was used. For this, chicken muscle was individually contaminated with tetracyclines (tetracycline, chlortetracycline, oxytetracycline, and doxycycline) and β-lactams (ampicillin, benzathine penicillin, dicloxacillin and oxacillin) at 0.5, 1.0 and 1.5 times their maximum residue level (MRL). Then, sarcoplasmic, myofibrillar and insoluble proteins were extracted and their content were measured using the Bradford method. Protein carbonylation was measured using the 2,4-Dinitrophenylhydrazine alkaline method.

Results: Residues of tetracyclines and β-lactams induced in vitro carbonylation on sarcoplasmic, myofibrillar and insoluble proteins even at 0.5MRL concentrations (p<0.05). When comparing the carbonylation induced by both antibiotics no differences were found (p>0.05). Variables such as the partition coefficient (log P) and the concentration of these antibiotics showed a high correlation with the oxidative capacity of tetracyclines and β-lactams on chicken breast proteins.

Conclusions: This study shows that the presence of tetracyclines and β-lactams residues at MRLs concentrations promotes in vitro carbonylation on chicken breast proteins. Our results provide important insights about the impact of antibiotics on the integrity of meat proteins intended for human consumption.
Evidence synthesis summary formats for clinical guideline development group members: a mixed-methods systematic review protocol
Authors: Sharp Melissa K. , Tyner Barrie , Awang Baki Dayang Anis Binti , Farrell Cormac , Devane Declan , Mahtani Kamal R. , Smith Susan M. , O'Neill Michelle , Ryan Máirín , Clyne Barbara
Published: July 2021

Introduction: Evidence syntheses, often in the form of systematic reviews, are essential for clinical guideline development and informing changes to health policies. However, clinical guideline development groups (CGDG) are multidisciplinary, and participants such as policymakers, healthcare professionals and patient representatives can face obstacles when trying to understand and use evidence synthesis findings. Summary formats to communicate the results of evidence syntheses have become increasingly common, but it is currently unclear which format is most effective for different stakeholders. This mixed-methods systematic review (MMSR) evaluates the effectiveness and acceptability of different evidence synthesis summary formats for CGDG members.

Methods: This protocol follows guidance from the Joanna Briggs Institute on MMSRs and is reported according to the Preferred Reporting Items for Systematic Reviews (PRISMA)-P guideline. A comprehensive search of six databases will be performed with no language restrictions. Primary outcomes are those relating to the effectiveness and preferences for and attitudes towards the different summary formats. We will include qualitative research and randomised controlled trials. Two reviewers will perform title, abstract, and full-text screening. Independent double-extraction of study characteristics and critical appraisal items will be undertaken using a standardised form. We will use a convergent segregated approach to analyse quantitative and qualitative data separately; results will then be integrated.

Discussion: The results of this systematic review will provide an overview of the effectiveness and acceptability of different summary formats for evidence synthesis findings. These findings can be helpful for those in or communicating to guideline development groups. The results can also inform the development and pilot-testing of summary formats for evidence summaries.
The soul of Russian culture
Authors: Kazakov Evgeniy
Published: July 2021

The monograph is devoted to the study of one of the "eternal" philosophical problems: the soul as a metaphysical essence of Russian culture, its structure, functioning and genesis. Special emphasis is placed on the analysis of the turning point for the modern Russian history of the Silver Age, which set the direction of events up to the present time. The study is the result of many years of work by the author, which is reflected in the books "The Genesis of spiritual life", "Soul: the metaphysics of self-determination", "Homo nudes", "The Heartbreaker".
It is addressed to teachers, graduate students, students and anyone interested in the metaphysics of the existence of Russian culture.
Assessment of Multiplier Potential of the Government Expenditure on the Economy Digitalization in Russia
Authors: Cherednichenko Larisa , Savinova M.
Published: July 2021

Research represented in this article is aimed to evaluate potential multiplier effect of expenditure on digitalization of Russian economy stated by the special National Program “Digital economy Russian Federation” for 2018 – 2024 as the planned indicators. In order to calculate multiplier effect authors have used potential autonomous expenditure multiplier coefficient which is directly related to the average propensity to consume domestically produced goods and services. Authors, using data of Russian statistics and own calculation, have measured the average size of multiplier coefficient in Russian economy over 2014 – 2019 and the size of potential multiplier effect that can be generated by National Program of digitalization. The position is substantiated that the development of own digital technologies can enhance the multiplier effect, contributing to economic growth.
Development of a Stakeholder Approach to Improving the Competitiveness of Health Resort Organizations
Authors: Levkevich M. , Konovalov V.
Published: July 2021

The article reveals the main directions of the development of the stakeholder approach to improving the competitiveness of health resort organizations, based on identifying the needs of the main groups of stakeholders and meeting them. Wellness organizations that balance the interests of internal stakeholders are represented in the market of wellness services in the position of strong participants, which, combined with a focus on customer needs, provides leadership for a long period of time. The practical use of the stakeholder approach by the management of health resorts will allow implementing a sustainable development strategy aimed at improving the quality of services and expanding their accessibility to citizens.
Modern Tools for Tax Incentives for Industrial Development in Russia in the Context of Sanctions Restrictions
Authors: Morkovkin D.
Published: July 2021

Russia's economic policy is aimed at solving the most important task, which is to ensure not only sustainable, but also accelerated socio-economic development, as well as improving the well-being of the population. As a result of the sanctions, the economy of any country loses a large amount of economic resources, motivational factors of development, which subsequently has an adverse impact on the main sectors of the real sector of the economy - industry and agriculture. In order to develop the economy in such conditions, the state seeks to support the most affected industries through the use of various tools that stimulate investment processes, and, as a result, the development of industry within the country. Fiscal and industrial policy play a key role in this. The study identifies and classifies the main instruments of tax incentives for industrial entities. The article highlights the current problems and promising areas of investment support in industry as a key factor in the sustainable development of the real sector of the Russian economy.
O Papel do Instagram na Decisão de Compras de Viagens de Lua de Mel: Um Estudo Sob a Perspectiva das Noivas.
Authors: Chagas de Lima Lia , de Sousa Pereira Nathália , Miranda de Oliveira Arruda Gomes Danielle
Published: July 2021

É cada vez mais perceptível, o poder de influência que as redes sociais têm sobre o comportamento do consumidor. Nesse sentido, este estudo buscou compreender como as postagens no Instagram influenciam no processo de decisão de compra de destinos turísticos de lua de mel. Além disso, foram delineados os seguintes objetivos específicos: identificar os tipos de postagens realizadas sobre turismo no Instagram que chamam atenção das noivas; identificar os principais influenciadores do processo de decisão de compra de destinos turísticos de lua de mel; e propor um framework do processo de decisão de compra de destinos turísticos de lua de mel. Assim, foi realizada uma pesquisa qualitativa exploratória, conduzida por entrevistas de profundidade. Foram encontrados dois tipos de postagens que mais chamam atenção das noivas: enfoque na estética e enfoque na estrutura turística. Identificaram-se ainda quatro tipos principais de influenciadores de destinos turísticos de lua de mel presentes no Instagram. Evidenciou-se que as postagens sobre viagens no Instagram atuam de forma relevante na decisão de compra de um destino turístico de lua de mel, pois os usuários que postam atuam como cocriadores das estratégias mercadológicas de conteúdo, mesmo sem ter intenção desta influência. Por fim, foi desenvolvido um framework do processo de decisão de compra de um destino turístico de lua de mel que mostrou que o Instagram é uma ferramenta essencial, pois o processo de decisão de compra se inicia nele antes da viagem e no final é retornado a ele através das postagens após ou durante as viagens.
Emociones positivas y marketing social en el Facebook de las ONGDs.
Authors: Galiano Coronil Araceli , Ravina Ripoll Rafael
Published: July 2021

Existe un gran interés por la comunidad académica en medir las emociones positivas. Bajo este paraguas, surge una importante literatura que empiezan a explorar estas emociones en el entorno del voluntariado de las ONGDs. Estas entidades emplean las redes sociales para comunicarse con la ciudadanía, siendo Facebook una de las más usadas ya que permite establecer una comunicación bidireccional con los usuarios. Desde esta perspectiva, el presente artículo quiere examinar la influencia de las emociones positivas y el marketing social en los mensajes que hablan de voluntariado a partir de la información proporcionada por los mensajes publicados en las 10 ONGDs más populares en Facebook durante el año 2019. Con este propósito se ha utilizado una metodología basada en minería de texto y análisis de contenido desde un enfoque cuantitativo y cualitativo. Para ello se usaron los programas informáticos SPSS V.27 y Nvivo 12 plus. Los resultados muestran que el número de likes está asociado con la aparición de términos sobre emociones positivas en los mensajes que hablan de voluntariado. También hay determinados vocablos con connotaciones positivas que son los más publicados por las organizaciones. Desde el punto de vista del marketing social, destaca el impacto conseguido por los mensajes informativos y el escaso impacto de los mensajes de comportamiento.
Nieudana wyprawa lisiogórska jako próba ruchu powstańczego w 1846 roku na terenie miasta Tarnowa i okolic w świetle wybranych tytułów prasowych
Authors: Piskozub Sławomir
Published: July 2021

The Unsuccessful Lisiogórska Expedition as an Attempt of the Insurrectionary Movement in 1846 on the Territory of the Town of Tarnow and its Surroundings in the Light of Memories of Franciszek Wiesiołowski

The article presents events which occurred on Tarnów lands before and during the unsuccessful insurrectionary movement in 1846 – the movement called Krakow Uprising. The article focuses on the fate of the count Franciszek Wiesiołowski who was appointed by the Central Committee in Poznań as the governor of Galicia responsible for the whole military movement on this area. The discussed period includes the time form the first days of February 1846 to 19 February, which means to the day when the independence burst on the Tarnów land was nipped in the bud. The article is mainly based on the diary of Franciszek Wiesiołowski – thanks to his personal account from the period preceding the uprising we get to know in detail the analyzed events, especially the expedition to Lisia Góra which was instantly stopped. This event, and the fact that other troops were dispersed or arrested, contributed to putting an end to the unfinished revolt. It was also the beginning of a short but violent period of chaos called the Galician Slaughter.
Integración curricular: articulación entre las instituciones educativas, los agentes locales y la ciudadanía joven de La Argentina de Pocora, Limón, Costa Rica
Authors: Vargas-Vargas Bryan Roberto
Published: July 2021

Este artículo muestra la experiencia pedagógica de integración curricular y articulación entre las instituciones educativas, los agentes locales y la ciudadanía joven de la comunidad rural de La Argentina de Pocora. A partir de la formulación de un proyecto pedagógico, se dan discusiones de fondo como la relación escuela-comunidad, la integración curricular, la construcción de un problema común y la postura epistemológica. Este documento mostrará las etapas cursadas en el propósito educativo desde las fases consultivas con la comunidad, hasta su implementación mediante la formación de las personas docentes. Así, se concluye con la trascendencia de la enseñanza-aprendizaje anclada a la comunidad para pensarse dentro de las condiciones, opor­tunidades o dificultades propias como sujeto social transformador.
La escuela rural, un espacio socialmente construido de posible resistencia territorial: miradas del territorio desde el papel de una docente rural
Authors: Gómez Tocarruncho Francy Yulieth , Bustos Velazco Edier Hernán , Reyes Roncancio Jaime Duván
Published: July 2021

La experiencia de trabajar asuntos relacionados con la educación y  categorías de la geografía desde el enfoque de Inteligencia Territorial,  genera reflexiones acerca de  la conciencia del lugar y produce diversas lecturas territoriales que inciden en la transformación de las relaciones entre las comunidades que integran la población escolar y la comunidad rural. En este caso, el trabajo de co-construcción participativa con diversos actores de la comunidad educativa desde la zona rural de la localidad de Ciudad Bolívar, en Bogotá y más concretamente, en la institución educativa Distrital Rural Mochuelo Alto propendió por comprender las diversas territorialidades que se conjugan allí, alrededor del desarrollo de una mesa territorial en la que se generó una propuesta de agenda para transformar situaciones propias del territorio que beneficien a la comunidad.
Innovación social y comunidades de aprendizaje en la enseñanza del urbanismo. Aportes del Observatorio Metropolitano de Tucumán (Argentina)
Authors: Llomparte Frenzel María Paula , Czytajlo Natalia Paola , Politi Silvia Alicia , Casares Marta Delia
Published: July 2021

Este artículo reflexiona sobre experiencias en entornos colaborativos de construcción y socia­lización de conocimiento desde el campo disciplinar del urbanismo que se desarrolla en un espacio de la universidad pública —el Observatorio de Fenómenos Urbanos y Territoriales—, a partir de la articulación de funciones de docencia, investigación y extensión. Se expone el uso de los mapas colaborativos como una metodología en el proceso de enseñanza-aprendizaje que promueve el reconocimiento y análisis del territorio metropolitano de la provincia de Tucumán, con indicadores y cartografía de temas vinculados a las políticas públicas y la nueva agenda urbana. Como resultado, se aportan experiencias pedagógicas desde las dimensiones emergentes de la planificación y el urbanismo: el género, el paisaje, la vulnerabilidad y el riesgo; así como innovaciones y herramientas replicadas en el contexto de pandemia, aislamiento social y virtualización de la enseñanza.