bluuebunny/crossref_metadata_2025 huggingface dataset:
Research trends and hotspots on connectomes from 2005 to 2021: A bibliometric and latent Dirichlet allocation application study
Authors: Yan Yangye , Fan Guoxin , Liao Xiang , Zhao Xudong
Published: December 2022

Background

This study aimed to conduct a bibliometric analysis of publications on connectomes and illustrate its trends and hotspots using a machine-learning-based text mining algorithm.

Methods

Documents were retrieved from the Web of Science Core Collection (WoSCC) and Scopus databases and analyzed in Rstudio 1.3.1. Through quantitative and qualitative methods, the most productive and impactful academic journals in the field of connectomes were compared in terms of the total number of publications and h-index over time. Meanwhile, the countries/regions and institutions involved in connectome research were compared, as well as their scientific collaboration. The study analyzed topics and research trends by R package “bibliometrix.” The major topics of connectomes were classified by Latent Dirichlet allocation (LDA).

Results

A total of 14,140 publications were included in the study. NEUROIMAGE ranked first in terms of publication volume (1,427 articles) and impact factor (h-index:122) among all the relevant journals. The majority of articles were published by developed countries, with the United States having the most. Harvard Medical School and the University of Pennsylvania were the two most productive institutions. Neuroimaging analysis technology and brain functions and diseases were the two major topics of connectome research. The application of machine learning, deep learning, and graph theory analysis in connectome research has become the current trend, while an increasing number of studies were concentrating on dynamic functional connectivity. Meanwhile, researchers have begun investigating alcohol use disorders and migraine in terms of brain connectivity in the past 2 years.

Conclusion

This study illustrates a comprehensive overview of connectome research and provides researchers with critical information for understanding the recent trends and hotspots of connectomes.
A bibliometric analysis of 100 top-cited journal articles related to acupuncture regulation of the autonomic nervous system
Authors: Zhao Zhanhao , Li Li , Xin Chen , Yin Yaqun , Zhang Rong , Guo Jing
Published: December 2022

Purpose

Research on the effects of acupuncture on autonomic function has been conducted for several decades, and a few notable studies have emerged in recent years. This study used bibliometric analysis to assess 100 top-cited articles to characterize the current status and research trends over the last three decades.

Methods

The 100 top-cited publications were identified from the Web of Science Core Collection database. The bibliometrix package in R was used for quantitative and qualitative analyses of the publication patterns and the country/region, institution, and author contributions. VOSviewer was used to construct networks based on co-citation analysis of the journals and the keyword co-occurrence.

Results

The 100 top-cited articles were identified with a total of 8,123 citations (range: 37–345). The majority of the articles came from the USA (n = 42), followed by Japan (n = 14) and mainland China (n = 13). Articles from the USA exhibited the largest number of citations (3,582 citations), followed by articles from Japan (1,189 citations), then articles from mainland China (755 citations). Neurosciences/Neurology was the most studied research area (n = 41). The Autonomic Neuroscience: Basic and Clinical published the largest number of papers (n = 14), while Brain Research received the largest number of citations (205 citations). Longhurst JC was the most productive author (10 publications), and Sato A was first among the cited authors (87 citations). The most frequently cited articles that focused on gastrointestinal, cardiovascular, or gynecologic responses to acupuncture regulation of the autonomic nervous system first appeared in the 1990s, peaked in the 2000s, then decreased after 2010. Publication of articles focused on the anti-inflammatory effects of acupuncture associated with autonomic function demonstrated an increasing trend over the last three decades.

Conclusion

From the initial studies focusing on the autonomic mechanism of visceral responses to acupuncture, researchers concentrated on exploring the autonomic mechanism of acupuncture in the control of systemic inflammation. Non-invasive electrical methods that activate somato-autonomic reflexes are current translational directions in clinical practice. Additional investigation of the underlying neuroanatomical basis of somato-autonomic reflexes also is needed.
Removing ocular artifacts from magnetoencephalographic data on naturalistic reading of continuous texts
Authors: Mäkelä Sasu , Kujala Jan , Salmelin Riitta
Published: December 2022

Naturalistic reading paradigms and stimuli consisting of long continuous texts are essential for characterizing the cortical basis of reading. Due to the highly dynamic nature of the reading process, electrophysiological brain imaging methods with high spatial and temporal resolution, such as magnetoencephalography (MEG), are ideal for tracking them. However, as electrophysiological recordings are sensitive to electromagnetic artifacts, data recorded during naturalistic reading is confounded by ocular artifacts. In this study, we evaluate two different pipelines for removing ocular artifacts from MEG data collected during continuous, naturalistic reading, with the focus on saccades and blinks. Both pipeline alternatives are based on blind source separation methods but differ fundamentally in their approach. The first alternative is a multi-part process, in which saccades are first extracted by applying Second-Order Blind Identification (SOBI) and, subsequently, FastICA is used to extract blinks. The other alternative uses a single powerful method, Adaptive Mixture ICA (AMICA), to remove all artifact types at once. The pipelines were tested, and their effects compared on MEG data recorded from 13 subjects in a naturalistic reading task where the subjects read texts with the length of multiple pages. Both pipelines performed well, extracting the artifacts in a single component per artifact type in most subjects. Signal power was reduced across the whole cortex in all studied frequency bands from 1 to 90 Hz, but especially in the frontal cortex and temporal pole. The results were largely similar for the two pipelines, with the exception that SOBI-FastICA reduced signal in the right frontal cortex in all studied frequency bands more than AMICA. However, there was considerable interindividual variation in the effects of the pipelines. As a holistic conclusion, we choose to recommend AMICA for removing artifacts from MEG data on naturalistic reading but note that the SOBI-FastICA pipeline has also various favorable characteristics.
Dissecting social decision-making: A spotlight on oxytocinergic transmission
Authors: Coccia Giulia , La Greca Filippo , Di Luca Monica , Scheggia Diego
Published: December 2022

Social decision-making requires the ability to balance both the interests of the self and the interests of others to survive in social environments. Empathy is essential to the regulation of this type of interaction, and it often sustains relevant prosocial behaviors such as altruism and helping behavior. In the last decade, our capacity to assess affective and empathy-like behaviors in rodents has expanded our understanding of the neurobiological substrates that underly social decision-making processes such as prosocial behaviors. Within this context, oxytocinergic transmission is profoundly implicated in modulating some of the major components of social decision-making. Thus, this review will present evidence of the association between oxytocin and empathy-like and prosocial behaviors in nonhuman animals. Then, we will dissect the involvement of oxytocinergic transmission—across different brain regions and pathways—in some of the key elements of social decision-making such as emotional discrimination, social recognition, emotional contagion, social dominance, and social memory. Evidence of the modulatory role of oxytocin on social decision-making has raised considerable interest in its clinical relevance, therefore we will also discuss the controversial findings on intranasal oxytocin administration.
Sex differences in the association of phase angle and lung cancer mortality
Authors: Shi Jinyu , Xie Hailun , Ruan Guotian , Ge Yizhong , Lin Shiqi , Zhang Heyang , Zheng Xin , Liu Chen’an , Song Mengmeng , Liu Tong , Zhang Xiaowei , Yang Ming , Liu Xiaoyue , Zhang Qi , Deng Li , Wang Xin , Shi Hanping
Published: December 2022

Background

Lung cancer is a lethal malignant tumor that is common worldwide and is associated with a high incidence of malnutrition. Phase angle (PA) is a simple, objective, and non-invasive indicator of body composition that has increasingly attracted attention as an indicator of the nutritional status and prognosis of patients with malignant tumors. This study aimed to investigate the association between the PA and overall survival in patients with lung cancer.

Methods

This study prospectively analyzed 804 lung cancer patients in the Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) project from 40 hospitals in China. We used a restricted cubic spline to analyze the sex-specific association between PA and mortality in men and women with lung cancer. Cox regression analysis was used to evaluate the independent association between PA and mortality in men and women. Sensitivity analysis was performed. The Kaplan–Meier method was used to evaluate the survival of patients with high and low PA values.

Results

There was an L-shaped association between PA and survival in both men and women with lung cancer (p = 0.019 and p = 0.121, respectively). Kaplan–Meier survival analysis suggested that patients with a high PA showed a better survival than patients with a low PA (p = 0.007 for men and p < 0.001 for women). Multivariate-adjusted Cox regression analysis showed that PA was an independent risk factor for mortality in men (HR = 0.79, 95% CI = 0.65–0.95, p = 0.015), but not in women (HR = 0.83, 95% CI = 0.67–1.04, p = 0.105).

Conclusion

Phase angle is an independent risk factor for the mortality of male lung cancer patients. However, its role in predicting the mortality of female lung cancer patients seems to be limited.
Fu brick tea alleviates high fat induced non-alcoholic fatty liver disease by remodeling the gut microbiota and liver metabolism
Authors: Tang Yan , Chen Bowei , Huang Xin , He Xu , Yi Jian , Zhao Hong , Tian Fengming , Liu Yingfei , Liu Baiyan
Published: December 2022

Fu brick tea (FBT) and its extracts have good lipid-lowering effects and have been used in the treatment of obesity in previous studies. Unfortunately, the therapeutic effect of FBT on non-alcoholic fatty liver disease (NAFLD) has not been thoroughly studied. In this study, we explored the mechanism by which FBT alleviates NAFLD from the perspective of the gut microbiota and liver metabolites. The results showed that FBT could reduce the body weight, liver weight and abdominal fat of NAFLD mice, and improve liver pathological morphology, liver lipid deposition, blood lipids and liver function. Moreover, FBT improved the diversity of the gut microbiota and changed the profile of liver metabolism in NAFLD mice. Further studies showed that FBT could ameliorate the cecum barrier, and regulate the effects of factors related to lipid synthesis in the cecum and liver of NAFLD mice. In conclusion, the present study confirmed that FBT can alleviate high fat induced NAFLD by regulating the homeostasis of the gut microbiota and liver metabolites.
Skeletal muscle mass index as a predictor of long-term cirrhosis onset in young non-cirrhotic males with acute-on-chronic liver failure
Authors: Bai Jie , Xu Manman , Peng Fengling , Gong Junwei , Zhao Jinqiu , Song Xiaodong , Li Yongguo
Published: December 2022

Background

The relationship between skeletal muscle mass index (SMI) and cirrhosis incidence in patients with non-cirrhotic acute-on-chronic (ACLF) has not been clarified. This study aimed to assess the predictive value of SMI on the incidence of long-term cirrhosis in male non-cirrhotic ACLF patients.

Materials and methods

Male ACLF patients who were free of liver cirrhosis were retrospectively included in this study. Univariate and multivariate logistic analyses were conducted to determine the risk factors for the long-term (1-year) development of cirrhosis. The receiver operating characteristic curves (ROC) were used to assess the ability of SMI levels to predict the incidence of cirrhosis. Restricted triple spline (RCS) described the dose-response relationship between SMI and the risk of cirrhosis. Subgroup analysis was stratified by age (≤ 40 years and > 40 years).

Results

A total of 230 subjects were included in this study, of whom 45.2% (104/230) were diagnosed with cirrhosis within 360 days. Patients who progressed to cirrhosis had a lower SMI [46.1 ± 6.9 versus 49.2 ± 6.5 cm2/m2, P = 0.001] and a higher proportion of sarcopenia (19.2% versus 6.3%, P = 0.003). In multivariate logistic regression, SMI remained a protective agent against 360-days progression to cirrhosis in males with ACLF after adjustment (OR 0.950, 95% CI: 0.908–0.994, P < 0.05). SMI exerted a non-linear dose-dependent effect on the risk of cirrhosis. The area under the ROC curve (AUC) for the L3-SMI to predict the incidence of cirrhosis in male non-cirrhotic ACLF patients was 0.636 (P < 0.001). We observed significant differences in SMI among male ACLF patients in different age groups. Further subgroup analysis by age revealed that lower SMI was associated with the 1-year incidence of cirrhosis in male ACLF patients aged less than 40 years (OR 0.908, 95% CI: 0.842–0.979, P < 0.05), whereas SMI did not affect the 1-year risk of cirrhosis in older subjects (age > 40 years).

Conclusion

A higher SMI represents an independent protective factor for developing long-term cirrhosis in male ACLF patients who do not experience cirrhosis, especially in those under 40 years of age.
A system based on deep convolutional neural network improves the detection of early gastric cancer
Authors: Feng Jie , Yu Shang rui , Zhang Yao ping , Qu Lina , Wei Lina , Wang Peng fei , Zhu Li juan , Bao Yanfeng , Lei Xiao gang , Gao Liang liang , Feng Yan hu , Yu Yi , Huang Xiao jun
Published: December 2022

Background

Early gastric cancer (EGC) has a high survival rate, but it is difficult to diagnosis. Recently, artificial intelligence (AI) based on deep convolutional neural network (DCNN) has made significant progress in the field of gastroenterology. The purpose of this study was to establish a DCNN assist system to improve the detection of EGC.

Methods

3400 EGC and 8600 benign images were collected to train the DCNN to detect EGC. Subsequently, its diagnostic ability was compared to that of endoscopists using an independent internal test set (ITS, including 1289 images) and an external test set (ETS, including 542 images) come from three digestive center.

Results

The diagnostic time of DCNN and endoscopists were 0.028s, 8.05 ± 0.21s, 7.69 ± 0.25s in ITS, and 0.028s, 7.98 ± 0.19s, 7.50 ± 0.23s in ETS, respectively. In ITS, the diagnostic sensitivity and accuracy of DCNN are 88.08%(95% confidence interval,95%CI,85.24%-90.44%), 88.60% (95%CI,86.74%-90.22%), respectively. In ETS, the diagnostic sensitivity and accuracy are 92.08% (95%CI, 87.91%- 94.94%),92.07%(95%CI, 89.46%-94.08%),respectively. DCNN outperformed all endoscopists in ETS, and had a significantly higher sensitivity than the junior endoscopists(JE)(by18.54% (95%CI, 15.64%-21.84%) in ITS, also higher than JE (by21.67%,95%CI, 16.90%-27.32%) and senior endoscopists (SE) (by2.08%, 95%CI, 0.75%-4.92%)in ETS. The accuracy of DCNN model was higher (by10.47%,95%CI, 8.91%-12.27%) than that of JE in ITS, and also higher (by14.58%,95%CI, 11.84%-17.81%; by 1.94%,95%CI,1.25%-2.96%, respectively) than JE and SE in ETS.

Conclusion

The DCNN can detected more EGC images in a shorter time than the endoscopists. It will become an effective tool to assist in the detection of EGC in the near future.
Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature
Authors: Ayeni Adewale Adeoba , Waterland Peter , Evans Matthew , Singhal Shika , Patel Rajan Kumar , Akingboye Akinfemi
Published: December 2022

It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, available data suggest early onset and synchronous cancers are synonymous to this group. We have reported an unusual case of multiple synchronous colorectal cancers in a young man with ulcerative colitis and Lynch syndrome also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC) gene mutation. We propose that conducting a detailed genetic mutation profile in LS patients may play a key role in guiding the intensity of endoscopic surveillance and that a concerted, pragmatic, patient guided approach should be adopted on the subject of prophylactic colectomy when UC and LS co-exist.
Identifying diagnostic markers and constructing a prognostic model for small-cell lung cancer based on blood exosome-related genes and machine-learning methods
Authors: Zhang Kun , Zhang Chaoguo , Wang Ke , Teng Xiuli , Chen Mingwei
Published: December 2022

Background

Small-cell lung cancer (SCLC) usually presents as an extensive disease with a poor prognosis at the time of diagnosis. Exosomes are rich in biological information and have a powerful impact on tumor progression and metastasis. Therefore, this study aimed to screen for diagnostic markers of blood exosomes in SCLC patients and to build a prognostic model.

Methods

We identified blood exosome differentially expressed (DE) RNAs in the exoRBase cohort and identified feature RNAs by the LASSO, Random Forest, and SVM-REF three algorithms. Then, we identified DE genes (DEGs) between SCLC tissues and normal lung tissues in the GEO cohort and obtained exosome-associated DEGs (EDEGs) by intersection with exosomal DEmRNAs. Finally, we performed univariate Cox, LASSO, and multivariate Cox regression analyses on EDEGs to construct the model. We then compared the patients’ overall survival (OS) between the two risk groups and assessed the independent prognostic value of the model using receiver operating characteristic (ROC) curve analysis.

Results

We identified 952 DEmRNAs, 210 DElncRNAs, and 190 DEcircRNAs in exosomes and identified 13 feature RNAs with good diagnostic value. Then, we obtained 274 EDEGs and constructed a risk model containing 7 genes (TBX21, ZFHX2, HIST2H2BE, LTBP1, SIAE, HIST1H2AL, and TSPAN9). Low-risk patients had a longer OS time than high-risk patients. The risk model can independently predict the prognosis of SCLC patients with the areas under the ROC curve (AUCs) of 0.820 at 1 year, 0.952 at 3 years, and 0.989 at 5 years.

Conclusions

We identified 13 valuable diagnostic markers in the exosomes of SCLC patients and constructed a new promising prognostic model for SCLC.
Perceived social support partially mediates the association between childhood abuse and pain-related characteristics
Authors: Pierce Jennifer , Presto Jacob , Hinckley Elizabeth , Hassett Afton L. , Dickens Joseph , Schneiderhan Jill R. , Grace Kathryn , McAfee Jenna
Published: December 2022

Higher perceived social support has been shown to buffer the impact of negative stressful events like childhood abuse on health outcomes. Yet, the role of perceived social support as a mediator of the association between childhood abuse and pain-related characteristics is not well understood. The present study explored this premise. Patients (n = 1,542) presenting to a tertiary-care, outpatient pain clinic completed a cross-sectional survey consisting of regularly collected clinical data and validated measures. Path analysis suggested that the impact of childhood abuse on sensory and affective pain-related characteristics was partially explained by perceived emotional support. Survivors of childhood abuse display a more complex clinical pain phenotype and this extends to more negative perceptions of social support. Our findings may reflect processes whereby childhood abuse negatively impacts social relationships across the lifespan, and these negative social perceptions and relationships influence sensory and affective components of pain.
Analysis of the positive results and influencing factors of hepatitis B antibody in hospitalized neonates with AgHBs positive mothers
Authors: Min Yu xiao , Gao Ying , Liu Chun tian , Lu Xiao yu , Chen Xiao chun
Published: December 2022

Purpose

To investigate the results of positive antibody to hepatitis surface antigen(anti-HBs)in hospitalized neonates whose mothers were hepatitis B surface antigen (AgHBs) positive and to explore the influencing factors.

Method

The study subjects were hospitalized neonates whose mothers were positive for AgHBs. According to the serological test results of five immune markers of hepatitis B virus (HBV), they were divided into positive for anti-HBs and negative for anti-HBs. Retrospective analysis of relevant factors affecting results of anti-HBs.

Result

269 cases (80.78%) were positive for anti-HBs and 64 cases (19.22%) were negative for anti-HBs. Univariate analysis results: the number of hepatitis B immunoglobulin (HBIG) injections after birth, whether HBIG was injected within 6 h, whether Hepatitis B vaccine (Hep B) was injected within 6 h, whether combined immunization within 12 h, whether Hep B was vaccinated on time after discharge, whether preterm birth, and whether low birth weight infants were statistically significant (P < 0.05). The results of binary logistic regression analysis: HBIG injection time ≤6 h (OR = 0.213), combined immunization time ≤12 h (OR = 0.024) were protective factors; premature infants (OR = 7.175), ALB/GLO (OR = 9.792) and failure to complete three vaccinations on time (OR = 12.659) were risk factors (P < 0.05).

Conclusion

Although China has implemented a national immunization program, vaccination of hospitalized neonates whose mothers are positive for AgHBs has not been effective. Therefore, it is recommended to strengthen training for medical staff and families to ensure that neonates can complete the three doses of vaccination on time after discharge from the hospital and to strengthen follow-up for premature infants.
FGF10 ameliorates lipopolysaccharide-induced acute lung injury in mice via the BMP4-autophagy pathway
Authors: Kong Xiaoxia , Lu Liling , Lin Daopeng , Chong Lei , Wen Shunhang , Shi Yaokai , Lin Lidan , Zhou Liqin , Zhang Hongyu , Zhang Hailin
Published: December 2022

Introduction: Damage to alveolar epithelial cells caused by uncontrolled inflammation is considered to be the main pathophysiological change in acute lung injury. FGF10 plays an important role as a fibroblast growth factor in lung development and lung diseases, but its protective effect against acute lung injury is unclear. Therefore, this study aimed to investigate protective effect and mechanism of FGF10 on acute lung injury in mice.

Methods: ALI was induced by intratracheal injection of LPS into 57BL/6J mice. Six hours later, lung bronchoalveolar lavage fluid (BALF) was acquired to analyse cells, protein and the determination of pro-inflammatory factor levels, and lung issues were collected for histologic examination and wet/dry (W/D) weight ratio analysis and blot analysis of protein expression.

Results: We found that FGF10 can prevent the release of IL-6, TNF-α, and IL-1β, increase the expression of BMP4 and autophagy pathway, promote the regeneration of alveolar epithelial type Ⅱ cells, and improve acute lung injury. BMP4 gene knockdown decreased the protective effect of FGF10 on the lung tissue of mice. However, the activation of autophagy was reduced after BMP4 inhibition by Noggin. Additionally, the inhibition of autophagy by 3-MA also lowered the protective effect of FGF10 on alveolar epithelial cells induced by LPS.

Conclusions: These data suggest that the protective effect of FGF10 is related to the activation of autophagy and regeneration of alveolar epithelial cells in an LPS-induced ALI model, and that the activation of autophagy may depend on the increase in BMP4 expression.
Methylome-wide association study of different responses to risperidone in schizophrenia
Authors: Du Huihui , Ma Jingsong , Zhou Wei , Li Mo , Huai Cong , Shen Lu , Wu Hao , Zhao Xianglong , Zhang Na , Gao Songyin , Wang Qi , He Lin , Wu Xuming , Qin Shengying , Zhao Mingzhe
Published: December 2022

Background: Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.

Methods: We performed a methylome-wide association study (MWAS) to evaluate the association between DNA methylation and the response to risperidone in schizophrenia. Genomic DNA methylation patterns were assessed using the Agilent Human DNA Methylation Microarray.

Results: We identified numerous differentially methylated positions (DMPs) and regions (DMRs) associated with antipsychotic response. CYP46A1, SPATS2, and ATP6V1E1 had the most significant DMPs, with p values of 2.50 × 10–6, 3.53 × 10–6, and 5.71 × 10–6, respectively. The top-ranked DMR was located on chromosome 7, corresponding to the PTPRN2 gene with a Šidák-corrected p-value of 9.04 × 10–13. Additionally, a significant enrichment of synaptic function and neurotransmitters was found in the differentially methylated genes after gene ontology and pathway analysis.

Conclusion: The identified DMP- and DMR-overlapping genes associated with antipsychotic response are related to synaptic function and neurotransmitters. These findings may improve understanding of the mechanisms underlying antipsychotic response and guide the choice of antipsychotic in schizophrenia.
Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines
Authors: Zhu Wenfang , Zhang Yiwen , Wang Yinghong
Published: December 2022

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition, which can be caused by a wide range of diseases, such as pneumonia, sepsis, traumas, and the most recent, COVID-19. Even though we have gained an improved understanding of acute lung injury/acute respiratory distress syndrome pathogenesis and treatment mechanism, there is still no effective treatment for acute lung injury/acute respiratory distress syndrome, which is partly responsible for the unacceptable mortality rate. In the pathogenesis of acute lung injury, the inflammatory storm is the main pathological feature. More and more evidences show that immune cells and cytokines secreted by immune cells play an irreplaceable role in the pathogenesis of acute lung injury. Therefore, here we mainly reviewed the role of various immune cells in acute lung injury from the perspective of immunotherapy, and elaborated the crosstalk of immune cells and cytokines, aiming to provide novel ideas and targets for the treatment of acute lung injury.
The vitellogenin receptor gene is involved in lifespan regulation of Zeugodacus cucurbitae (Coquillett) after short-term high-temperature treatment
Authors: Lian Yuyang , Peng Sihua , Yang Xiaofeng , Jia Jingjing , Li Jinlei , Wang Aqiang , Yang Shuyan , Zheng Rongjiao , Zhou Shihao
Published: December 2022

Zeugodacus cucurbitae (Coquillett) is a highly damaging agricultural pest in many tropical and subtropical countries around the world and high temperatures usually affect its survival. To clarify the effect of short-term high temperatures on the survival and lifespan of Z. cucurbitae, newly emerged adults of three consecutive generations (F1, F2, and F3) were exposed to 25 °C, 33 °C, 37 °C, 41 °C, or 45 °C treatments for 1 h. The effect of these temperatures on survival and lifespan was evaluated using biological indicators such as lifespan and pupation rate. Then, to study the molecular regulatory mechanism of the lifespan of Z. cucurbitae after short-term high-temperature treatment, we exposed the newly emerged adults to 25 °C or 45 °C treatments for 1 h and used siRNA to interfere with the expression of the vitellogenin receptor (VgR) gene in the female to study the effect of the VgR gene on the lifespan of Z. cucurbitae. The results showed that the survival rate, lifespan, pupae weight, pupation rate, and emergence rate of Z. cucurbitae decreased with increased temperature, while the female sex ratio of offspring increased. The heat resistance of females was higher than that of males. Interference with the expression of the VgR gene resulted in shortening of the female’s lifespan by approximately 60% after exposure to 25 °C or 45 °C treatments for 1 h, which indicated involvement of the VgR gene in the regulation of Z. cucurbitae lifespan. This study provides a reference to guide integrated control of Z. cucurbitae in high-temperature seasons.
Characteristics and transcriptomic analysis of scar tissues on the inner uterine cavity wall in patients with intrauterine adhesions
Authors: Li Waixing , Gu Pan , Gao Bingsi , Zou Lingxiao , Zhang Aiqian , Huang Huan , Zhao Xingping , Xu Dabao , Cheng Chunxia
Published: December 2022

Introduction: It has been previously reported that intrauterine adhesions (IUAs) are the main cause of uterine infertility. However, the histological origin of scar tissue present on the inner wall of the uterine cavity with IUAs has not been previously studied, which is particularly necessary for follow‐up research and prevention and treatment.

Methods: In this study, myometrium with normal uterus were assigned to the control group and scar tissues with IUAs were assigned to the experimental group. And pathological characteristics and transcriptomic were analyzed between the two groups.

Results: We founded no difference was noted in the histological morphology and the α-SMA expression between the experimental and control groups. A total of 698 differentially expressed genes were identified between the two groups. Gene Ontology (GO) analyses revealed that the DEGs were significantly enriched in cell proliferation, AP-1 complex formation, and angiogenesis. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that the target genes were significantly enriched in the AGE-RAGE, FOXO and TNF signaling pathway.

Discussion: As far as we know, this is the first study to propose that the scar tissues are mainly derived from the myometrium and the first one to report differentially expressed genes in the scar tissues of IUAs.
Transcriptome analysis reveals that jasmonic acid biosynthesis and signaling is associated with the biosynthesis of asperosaponin VI in Dipsacus asperoides
Authors: Xu Jiao , Hu Zhengping , He Hua , Ou Xiaohong , Yang Yang , Xiao Chenghong , Yang Changgui , Li Liangyuan , Jiang Weike , Zhou Tao
Published: December 2022

Dipsacus asperoides is a perennial herb, the roots of which are abundant in asperosaponin VI, which has important medicinal value. However, the molecular mechanism underlying the biosynthesis of asperosaponin VI in D. asperoides remains unclear. In present study, a comprehensive investigation of asperosaponin VI biosynthesis was conducted at the levels of metabolite and transcript during root development. The content of asperosaponin VI was significantly accumulated in two-leaf stage roots, and the spatial distribution of asperosaponin VI was localized in the xylem. The concentration of asperosaponin VI gradually increased in the root with the development process. Transcriptome analysis revealed 3916 unique differentially expressed genes (DEGs) including 146 transcription factors (TFs) during root development in D. asperoides. In addition, α-linolenic acid metabolism, jasmonic acid (JA) biosynthesis, JA signal transduction, sesquiterpenoid and triterpenoid biosynthesis, and terpenoid backbone biosynthesis were prominently enriched. Furthermore, the concentration of JA gradually increased, and genes involved in α-linolenic acid metabolism, JA biosynthesis, and triterpenoid biosynthesis were up-regulated during root development. Moreover, the concentration of asperosaponin VI was increased following methyl jasmonate (MeJA) treatment by activating the expression of genes in the triterpenoid biosynthesis pathway, including acetyl-CoA acetyltransferase (DaAACT), 3-hydroxy-3-methylglutaryl coenzyme A synthase (DaHMGCS), 3-hydroxy-3-methylglutaryl coenzyme-A reductase (DaHMGCR). We speculate that JA biosynthesis and signaling regulates the expression of triterpenoid biosynthetic genes and facilitate the biosynthesis of asperosaponin VI. The results suggest a regulatory network wherein triterpenoids, JA, and TFs co-modulate the biosynthesis of asperosaponin VI in D. asperoides.
Gene fusions, micro-exons and splice variants define stress signaling by AP2/ERF and WRKY transcription factors in the sesame pan-genome
Authors: Parakkunnel Ramya , Naik K Bhojaraja , Vanishree Girimalla , C Susmita , Purru Supriya , Bhaskar K Udaya , Bhat KV. , Kumar Sanjay
Published: December 2022

Evolutionary dynamics of AP2/ERF and WRKY genes, the major components of defense response were studied extensively in the sesame pan-genome. Massive variation was observed for gene copy numbers, genome location, domain structure, exon-intron structure and protein parameters. In the pan-genome, 63% of AP2/ERF members were devoid of introns whereas >99% of WRKY genes contained multiple introns. AP2 subfamily was found to be micro-exon rich with the adjoining intronic sequences sharing sequence similarity to many stress-responsive and fatty acid metabolism genes. WRKY family included extensive multi-domain gene fusions where the additional domains significantly enhanced gene and exonic sizes as well as gene copy numbers. The fusion genes were found to have roles in acquired immunity, stress response, cell and membrane integrity as well as ROS signaling. The individual genomes shared extensive synteny and collinearity although ecological adaptation was evident among the Chinese and Indian accessions. Significant positive selection effects were noticed for both micro-exon and multi-domain genes. Splice variants with changes in acceptor, donor and branch sites were common and 6-7 splice variants were detected per gene. The study ascertained vital roles of lipid metabolism and chlorophyll biosynthesis in the defense response and stress signaling pathways. 60% of the studied genes localized in the nucleus while 20% preferred chloroplast. Unique cis-element distribution was noticed in the upstream promoter region with MYB and STRE in WRKY genes while MYC was present in the AP2/ERF genes. Intron-less genes exhibited great diversity in the promoter sequences wherein the predominance of dosage effect indicated variable gene expression levels. Mimicking the NBS-LRR genes, a chloroplast localized WRKY gene, Swetha_24868, with additional domains of chorismate mutase, cAMP and voltage-dependent potassium channel was found to act as a master regulator of defense signaling, triggering immunity and reducing ROS levels.
The relationship between teachers’ emotional intelligence and teaching for creativity: The mediating role of working engagement
Authors: Su Huili , Zhang Jingwei , Xie Mingyue , Zhao Ming
Published: December 2022

Teaching for creativity (TfC) has received increasing attention as an important way to cultivate students’ creative thinking and behaviors. The purpose of this study is to examine the mediating role of teachers’ work engagement (WE) on the relationship between their emotional intelligence (EI) and teaching for creativity. The study is a cross-sectional design. The sample of the study is 3,307 secondary school English teachers working in Jilin Province, China. The findings show that the teachers’ perceptions of emotional intelligence, work engagement and teaching for creativity are relatively high. The findings confirm the hypotheses. The results of structural equation modeling and bootstrapping show that teachers’ emotional intelligence is positively correlated with work engagement and teaching for creativity, and teachers’ work engagement mediates the relationship between emotional intelligence and teaching for creativity.
A phenomenological exploration of work-related post-traumatic growth among high-functioning adults maltreated as children
Authors: Kaye-Tzadok Avital , Icekson Tamar
Published: December 2022

Introduction

Childhood maltreatment is a highly prevalent traumatic experience, and its adverse psychological and behavioral consequences are well-documented. Notwithstanding these adverse outcomes, many individuals who suffered from traumatic experiences report post-traumatic growth, i.e., transformative positive changes resulting from their struggle to cope. Post-traumatic growth has been extensively explored among adult survivors of childhood maltreatment, with findings indicating both the previously recognized domains (personal strength, relating to others, appreciation of life, openness to new possibilities, and spiritual change) as well as abuse-specific domains of growth (e.g., increased ability to protect themselves from abuse). However, little attention has been given to vocational aspects of post-traumatic growth among survivors, despite the central role and importance of work in adulthood. Exploration of post-traumatic growth at work has focused on certain vocational traumatic experiences, such as those which occur in the military, or through secondary trauma. This exploratory qualitative study focuses on the question: What is the lived experience of work-related post-traumatic growth among high-functioning adult survivors of CM?

Method

Twenty in-depth interviews were held with high-functioning working adults who were maltreated as children. Phenomenological analysis was applied to the retrospective data reported in these interviews.

Result

Rich descriptions of work-related positive psychological changes were provided by all participants. Analysis revealed that survivors’ post-traumatic growth corresponded with all five previously recognized domains of growth: changes in self, relating to others, openness to new possibilities, finding meaning to the abuse, and appreciation of life. It also revealed that work is perceived as a form of resistance (a subtheme of changes in self), and that finding meaning entails three emerging subthemes: being a survivor and a role model, giving others what was needed and never received, and making a better world.

Discussion:

While the vocational lives of survivors of childhood maltreatment have rarely been examined through the lens of post-traumatic growth, our results show this lens to be highly valuable. Work-related post-traumatic growth has relevance not only regarding vocational traumas occurring in adulthood as has been previously studied, but also in the context of childhood traumas. Moreover, our research broadens the understanding of the possible domains of work-related growth.
Accelerating the science and practice of psychology beyond WEIRD biases: Enriching the landscape through Asian psychology
Authors: Wong Paul T. P. , Cowden Richard G.
Published: December 2022

More than a decade has passed since major concerns emerged about the WEIRD-centric focus of mainstream psychological science. Since then, many calls have been made for the discipline of psychology (and other disciplines within the social sciences) to become more broadly representative of the human species. However, recent evidence suggests that progress toward improving the inclusivity and generalizability of psychological science has been slow, and that the dominance of WEIRD psychology has persisted. To build a more comprehensive psychological science that truly represents the global population, we need strategies that can facilitate more rapid expansion of empirical evidence in psychology beyond WEIRD biases. In this paper, we draw on several examples (i.e., non-duality and dialectical interaction, Wu-Wei, Zhong Yong) to illustrate how principles of Asian psychology could contribute to reshaping mainstream psychology. We discuss some strategies for advancing a global psychological science, along with some complementary practical suggestions that could enrich the WEIRD-centric landscape of current psychological science.
The role of leadership in collective creativity and innovation: Examining academic research and development environments
Authors: Huang Zijian , Sindakis Stavros , Aggarwal Sakshi , Thomas Ludivine
Published: December 2022

Introduction

Leadership is pragmatically linked to innovation adoption and implementation at a team level, as managers oversee the strategic decisions and policymaking, control resources, and moderate the scanning and searching of the environment. The paper attempts to provide new concepts and examines theoretical and practical implications to better understand how the leadership role is executed in an R&D environment to foster team creativity and innovation.

Methods

A quantitative analysis was plausible over qualitative research mainly because the survey was conducted using a single technique, employing a questionnaire that was selected after checking the principal component analysis (PCA) and confirmatory factor analysis (CFA).

Results

The findings show that the production of ideas positively impacts leadership, leading to growth and competitive advantage for the organization. Also, the PMEG (people, means, effects, goals) framework will positively impact leadership as leaders focus on those factorsthat influence an individual’s attitudes, behaviors, and interactions between groups.

Discussion

The paper highlights the involvement of R&D organizations and groups in developing innovative products, services, technologies, and processes that further positively impact a team. This study is the first to highlight the role of the PMEG framework with the factors that influence an individual’s attitudes, behaviors, and interactions between groups. The study’s main contribution is to explore creativity as a potential mediator for leadership–organizational innovation.
The evolution of language by sexual selection
Authors: Worden Robert
Published: December 2022

Most accounts of the evolution of language assume that language and greater intelligence are beneficial adaptations, leading to increases in survival fitness. These accounts emphasise natural selection, with language as an adaptation to the habitat, placing less emphasis on sexual selection and reproductive fitness. An account of language evolution by natural selection alone faces problems in accounting for the prodigious power and expressivity of human language. Modern language (and its recent antecedents) would appear to offer only small incremental benefits over simpler language, which would require a smaller brain with smaller metabolic costs. Accounts by natural selection also face problems in accounting for the uniqueness of human language and intelligence. I therefore consider a hybrid account, in which both natural selection and sexual selection played a role in the evolution of language and intelligence, probably at different times. Specifically, in this account, early language was driven by natural selection to collaborate. Then later humans became subject to sexual selection for superior intelligence, with language acting as the main display mechanism for intelligence. It is hard to determine the relative roles of natural and sexual selection over the time course of the evolution of language. In the later stages, sexual selection to display intelligence drove a runaway selection process towards powerful modern language. This hybrid account retains the benefits of accounts by natural selection, while also accounting for the prodigious power of human language and intelligence, and for its uniqueness compared to other primates. Sexual selection often leads to traits which are unique to a species, and are exaggerated beyond natural needs. On this account, the capability for language may have evolved in the order: (1) pragmatics and a theory of mind; (2) using single words and constructions; (3) learning and using syntax. In this model, relevance-based pragmatics evolved before language; then, single words and constructions came into use; and later, syntax condensed out of pragmatics, as a codification of some pragmatic rules of inference. This order requires only incremental extensions of primate cognition, and agrees with the order in which children learn language.
“I agree with LGBT rights, but…”: Authoritarianism and social dominance orientation underlying hypocritical attitudes of Taiwan society
Authors: Hsu Han-Yu
Published: December 2022

In the modern public sphere, ordinary people may display hypocrisy in political participation, showing contradictory attitudes across different social issues. But there still exists another type of hypocritical attitude within one single issue, such as agreeing with LGBT rights but refusing to amend the current Civil Code simultaneously in the case of Taiwan. In the same-sex marriage legalizing process, the hypocritical attitude could be observed in Taiwan’s conservative campus, together with the explicitly prejudiced attitude. In this article, we explored the existence of the hypocritical attitude on this issue and discovered its psychological foundations. We conducted an online questionnaire survey in 2018 (N = 544) to measure Taiwanese participants’ attitudes toward same-sex marriage and their psychological dispositions of Right-Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO). Our results showed that while attitudes toward LGBT rights and special-law were negatively correlated, several participants showed the hypocrisy of positive attitudes toward the two sets of questions simultaneously. The hypocritical people shared similar psychological dispositions with the explicitly prejudiced people as high in RWA and SDO while differentiated from the LGBT-friendly people. Attitudinal hypocrisy and explicit prejudice constitute two sides of the conservative camp in Taiwan, which is based on the Confucianism cultural value of interpersonal harmony. The cultural and societal implications were discussed.