bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats
Authors: Wang Yi-Ying , Chao Shih-Ching , Su Pei-Yuan , Lo Hui-Chen
Published: November 2024

The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T. versicolor-ePSP on regulating glucose metabolism, including insulin signaling molecules and glucose metabolism-associated enzymes, in the liver of rats with type 2 diabetes mellitus (T2DM). Male Wistar rats, fed with a high-fat diet followed by a streptozotocin injection to induce T2DM, were orally administered water or T. versicolor-ePSP at doses of 0.1, 0.5, or 1.0 g/kg/d. After 4 weeks of T. versicolor-ePSP administration, T2DM rats exhibited significantly lower postprandial blood glucose levels, decreased liver triglyceride and cholesterol contents, and improved serum liver function indices in a dose-dependent manner (P < 0.05, one-way ANOVA). Additionally, T2DM rats administered T. versicolor-ePSP had significantly activated insulin receptors and decreased proteins involved in insulin signaling pathway, such as insulin receptor substrates, PI3K, and total and activated Akt, and AMP-activated protein kinase in the liver. T. versicolor-ePSP administration, especially at 1.0 g/kg per day, significantly increased glucose transporters in the cell membrane and decreased glucokinase and glucose-6-phosphotase in the cytosol of the liver. In conclusion, the antihyperglycemic activities of T. versicolor-ePSP may be associated with enhanced hepatic function, alleviated gluconeogenesis, and facilitated glucose transport in an insulin- and AMPK-independent manner in the liver of T2DM rats.
Screening and inclusion of luteolin for β-cyclodextrin: molecular simulations and experiments
Authors: Song Meng , Wang Chaole , Zhang Sen , Song Jihong , Hu Zhenyu , Zhou Shuya , Li Yunan , Wang Lei , Cao Fengyi
Published: November 2024

In this study, we first established a guest small molecule screening mechanism by molecular simulation and then screened lignans from ten polyphenolic compounds to identify the most suitable guest molecule for encapsulation with β-cyclodextrin (β-CD). Subsequently, the subject–guest interactions and encapsulation mechanisms of lignans with β-CD, 2-hydroxypropyl-cyclodextrin, and 2,6-dimethyl-cyclodextrin (DM-β-CD) were investigated using a combination of molecular simulation and experimental methods, respectively. Molecular simulations were performed to calculate the microstructural parameters, including solubility parameters, binding energies, and mean square displacements. The simulation results demonstrated that DM-β-CD exhibited the strongest interaction with luteolin and formed the most stable inclusion complex. The inclusion complexes of luteolin with the three cyclodextrins were prepared by the freeze-drying method, and the formation of the inclusion complexes was demonstrated using infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and ultraviolet-visible spectroscopy. Phase solubility studies confirmed the formation of 1:1 stoichiometric inclusion complexes of lignans with cyclodextrins. Furthermore, 2,2-diphenyl-1-pyridine hydrazine free radical scavenging experiments demonstrated that the inclusion complexes exhibited enhanced antioxidant capacity. In light of these findings, it can be concluded that among the three cyclodextrins, DM-β-CD was optimally encapsulated with luteolin.
Ciencias Naturales. Afectación del ecosistema por la mano del hombre.
Authors:   Ministerio de Educación, Unidad Educativa Zapotal, Engracia Magallon Azucena Liliana , Rodríguez Vera Felipa Esther ,   Ministerio de Educación, Unidad Educativa Zapotal, Parra Guerrero Brigitte Aracely ,   Ministerio de Educación, Unidad Educativa Zapotal
Published: November 2024

La mano del hombre ha dejado una huella profunda en el planeta, transformando ecosistemas y alterando los procesos naturales. A lo largo de la historia, la actividad humana ha tenido un impacto cada vez mayor en las ciencias naturales, con consecuencias tanto positivas como negativas. Como impactos positivos pueden mencionarse: el desarrollo científico y tecnológico, la conservación de especies, desarrollo de energías renovables; pero, también hay impactos negativos como el cambio climático, la pérdida de biodiversidad, la contaminación, la sobreexplotación de recursos naturales, entre otras, de manera que algunas disciplinas de las ciencias naturales han sido afectadas, pero, ¿Qué podemos hacer? ¿Cómo mejorar el impacto de la actividad humana en las ciencias naturales?
'Visceral Bodies' Special Issue Editorial
Authors: Argirò Anna , Čičigoj Katja , Brook Anna
Published: November 2024

Editorial by the guest editors (Anna Argirò, Anna Brook and Katja Čičigoj) introducing the Visceral Bodies Special Issue of Studies in the Maternal.
Disiplinleşme ve Kamu Yönetimiyle İlişkilenme Süreci Bağlamında İşletme Yönetimi
Authors: Dülgar İmren Pınar
Published: November 2024

İşletme yönetimi, kamu yönetiminde egemen yaklaşımlara kuramsal kaynaklık eden bir disiplindir. İşletmecilik kuramlarının kamu yönetimine aktarımı ve bu alanda doğurduğu etki, 1980’li yıllar sonrası ekonomi politikalarıyla ilişkili olarak birçok çalışmaya konu edilmiştir. Bu makale ise etki yerine kaynağın kendisini ele almak üzere tarihsel bakışı başlangıca yöneltmektedir. Kaynağın ele alınmasıyla disiplinlerin inceleme nesnesi (somut olan) farklılığına rağmen somuttan üretilen kuramsal bilgi (soyut olan) ortaklaşmasının nedeninin ortaya konulması amaçlanmaktadır. Makalede, işletme yönetiminin bir disiplin olarak gelişiminin tarihsel bağlamı çözümlenerek inceleme nesnesi/varlık sebebi kavranmaktadır. Özel sektör dünyasına ait sistemli bir bilgi bütünü olarak disiplin, ilk ifadesini büyük örgütlerin şirket formunda yaygınlaştığı ve anonim şirketlerin yönetim işlevindeki ayrımı güçlendirdiği 19. yüzyıl Amerika’sında kazanmıştır. İşletme yönetiminin kamu yönetimine kaynaklık etmesini sağlayan ilk yaklaşım ise fabrikadan geliştirilen ve disiplinin kurucu yaklaşımı olan Bilimsel Yönetim’dir. Bu yaklaşımla işletme yönetimi henüz kuruluş aşamasında kamu yönetimiyle ilişkilenmiş ve fabrika yönetiminden tüm örgütlere doğru görüş alanını genişletmiştir. Yönetim bilgisinin evrensel/özel-kamu ayrımı olmaksızın her örgütte uygulanabilir olduğu savıyla nesne farkını gözetmeyen yaklaşımlar, piyasa örgütlerinden üretilen bilginin kamu yönetiminde geçerliliği kabulüne yol açmıştır.
Ecological and biological features of Adonis apennina L. (Ranunculaceae) in the south of the Tomsk region
Authors:   National Research Tomsk State University, Prokopyev Alexey S. , Kataeva Tatjana N. ,   National Research Tomsk State University
Published: November 2024

Three local cenopopulations of Adonis apennina L. were studied in the south of the Tomsk region (environment of the village of Kolarovo, Tomsk region), where the species occurs among meadow-forest herbs. The density of individuals in the studied local areas is low – from 0.7 individuals/m2 to 2.8 individuals/m2. The age composition is characterized by incompleteness: there are no individuals of the pregenerative period or the aging fraction. The reproductive potential has been poorly realized; the seed productivity of an individual shoot is relatively low. In anthropogenically disturbed communities, the productivity of individuals is reduced by more than half. Renewal and maintenance of the number of individuals in natural conditions is carried out exclusively by seed. A comparative analysis of the morphological characteristics of A. apennina in various ecological and cenotic conditions showed that the largest individuals develop in undisturbed communities or those experiencing weak anthropogenic impact. Located in the vicinity. With. Kolarovo has two specially protected natural areas – the landscape natural monument “Kolarovo wetlands” and the botanical natural monument “Slope with relict vegetation near the village. Kolarovo” occupy relatively small areas and are not able to cover all locations of rare species. Based on the research, recommendations were given for the protection of Adonis apennine in the Tomsk region.
Litological and Geochemical Features of Carbonate Rocks of the Riphean Deposits of the Kamsko-Belskiy Trough
Authors:   Institute of Geology of the Russian Academy of Sciences, Dyakova S. A. , Bashkova S. E. ,   Perm State University, Sergeeva N. D. ,   Institute of Geology of the Russian Academy of Sciences
Published: November 2024

The article is devoted to the study of lithological and geochemical features of carbonate rocks of the Kaltasinskaya, Shikhanskaya and Leuzinskaya formations of the Riphean deposits in the Kamsko-Belskiy Trough of the Volga-Ural oil and gas basin. A detailed lithological and stratigraphic description was carried out and statistical processing of the results of geochemical studies of 150 samples of carbonate rocks of the Riphean in 19 wells of the Kamsko-Belskiy Trough was carried out. According to the results of the research, the rocks of the Arlan subformation of the Kaltasin formation were attributed to the oil-bearing strata with a high potential of regeneration. The results of the study of the Shikhanskaya and Leuzinskaya formations of the upper Riphean allowed us to identify only rocks with poor generation potential.
A Supervised Workflow for Predicting Lithofacies in Complex and Heterogeneous Tight Sandstone Reservoirs: A Data-Driven Approach Using Clustering and Classification Models
Authors:   Institute of Geophysics & Geomatics, China University of Geosciences, Ali Muhammad
Published: November 2024

This study introduces a novel supervised workflow for predicting lithofacies in complex, heterogeneous tight sandstone reservoirs with intercalated facies. Using a two-information criteria clustering method, six distinct facies are identified, providing an unbiased, data-driven alternative to manual approaches. Among classification models, Gaussian Process Classification (GPC) outperforms others, including Support Vector Machine (SVM) and Artificial Neural Network (ANN), with Random Forest (RF) performing less effectively. GPC accurately predicts lithofacies in testing data and is assessed for similarity accuracy. Predicted lithofacies are integrated into acoustic impedance versus velocity ratio cross plots, resulting in 2D probability density functions. These, combined with depth data, feed a neural network to forecast synthetic gamma-ray log responses. Results show strong agreement between measured and predicted gamma-ray logs (R2 = 0.978) and nearly identical log trends. Additionally, the predicted lithofacies are classified using inverted impedance and velocity ratio volumes, yielding a facies prediction volume that aligns well with well site lithofacies classification, even without core data
Technological Solutions for Groundwater Treatment from Dissolved Petroleum Products
Authors:   Perm State University, Maksimovich N. G. , Khmurchik V. T. ,   Perm State University, Demenev A. D. ,   Perm State University, Berezina O. A. ,   Perm State University, Mizev A. A. ,   Perm State University
Published: November 2024

The priority in the oil industry is to reduce the technogenic load on environmental components. Modern technologies allow minimizing the negative impact on water bodies, soils, vegetation, etc. However, the development of effective technical solutions aimed at purification of underground water from oil products is still in progress. There are mechanical, physical-chemical, and biological methods of oil pollution control. Each method has advantages and limitations and can be used in different situations. The technology of groundwater treatment based on biotechnological method and dosed oxygen supply is proposed. The recommended solution can be used as an independent environmental protection measure or in addition to existing ones.
Engineering and Geological Surveys in the Interfluve of the Kama River and the Lower Course of the Belaya River for the Buildings and Structures Construction
Authors:   Bashkir State Agrarian University, Khaydarshina E. V. , Zagitova L. R. ,   Bashkir State Agrarian University, Gaziev I. A. ,   Bashkir State Agrarian University, Kagirova R. R. ,   Bashkir State Agrarian University
Published: November 2024

The article considers the engineering-geological conditions of the territory of industrial and civil engineering development. Oil production, the cities expansion, and favorable natural conditions cause the intensive construction of buildings for various purposes, and industrial facilities. Information about the characteristics of soils, the level of groundwater occurrence, geological and physical processes that are important for choosing a foundation is needed for proper construction of objects. The geological structure of the area under consideration is characterized by a thick Paleozoic sedimentary cover overlain by Quaternary deposits such as sandy loam, loam, sand, and gravel-pebble rocks.
A Complex of Geoelectrical Methods for Studying the Chemical Contamination of Groundwater in the Zone of Influence of Technogenic Objects
Authors:   F. Skorina Gomel State University, Gusev A. P. , Kulyba E. I. ,   F. Skorina Gomel State University, Prilutsky I. O. ,   F. Skorina Gomel State University
Published: November 2024

The work is devoted to the assessment of chemical contamination of groundwater based on the use of a complex of geoelectric methods. A complex has been tested, including surveying the natural electric field potential, resistivity measurements of surface waters and soils, electrical profiling, and vertical electrical sounding. The developed complex allows to quickly and effectively assessing groundwater pollution in the upper part of the geological environment, determine the direction of movement of pollution, the area and depth of contaminated water.
Sustentabilidad ambiental rural y servicios ecosistémicos: una revisión
Authors: Sandoval Muelas Diomedes Arnoldo , Beltran Vargas Julio Eduardo
Published: November 2024

Los servicios ecosistémicos tienen un rol preponderante para explicar la sustentabilidad ambiental rural, al incidir en el estado de bienestar y relaciones sociales, que condicionan la capacidad en estas zonas para garantizar la sustentabilidad ambiental. En este trabajo investigativo de revisión se analizan los avances existentes, en torno a las formas de evaluación de los servicios ecosistémicos en la sustentabilidad ambiental rural. El estudio empleó las bases de datos de Scopus, ScienceDirect, Taylor & Francis y JSTOR, y se utilizó un marco de búsqueda de tres etapas: exploración, síntesis y análisis. Del total de casos de estudio, la suma de la frecuencia de citación fue de 200 veces, de estos el 57% de las citaciones correspondió a un servicio de aprovisionamiento, el 29% a un servicio de regulación y el 14% a un servicio cultural. Destacándose en los servicios de aprovisionamiento el suministro de cultivos (32,5%), en los servicios de regulación la conservación del suelo (41,38%) y en los servicios culturales el conocimiento tradicional (89%).
Representaciones sociales ambientales de adolescentes escolarizados sobre humedales en la subregión del Bajo Sinú, Colombia
Authors: Humanez Otero Jorge Samuel , Valencia Jiménez Nydia Nina , Ortega Montes Jorge Eliécer
Published: November 2024

Introducción: Dada la sistemática desaparición, disminución o transformación que presentan los humedales alrededor del mundo, conviene preguntar por la forma en que los adolescentes y jóvenes representan socialmente este ecosistema y cómo estas pueden llegar a convertirse en prácticas ambientales que impacten positiva o negativamente en el funcionamiento de dichos ecosistemas. Objetivo: Comprender las representaciones sociales ambientales que tienen los adolescentes escolarizados de la subregión Bajo Sinú, respecto a los humedales y de la Ciénaga Grande del Bajo Sinú. Método: Diseño cualitativo de tipo fenomenológico hermenéutico. La población participante fueron 30 adolescentes matriculados en instituciones educativas de la subregión Bajo Sinú, en el departamento de Córdoba, a quienes se les aplicó un cuestionario con preguntas abiertas, además, estos estudiantes se distribuyeron en 3 grupos focales realizados durante el primer semestre de 2022. Resultados: Las representaciones sociales ambientales de los adolescentes en relación al concepto humedal y de la Ciénaga Grande del Bajo Sinú, principalmente son de tipo naturalista, tras centrarse en aspectos bióticos y abióticos del humedal. Conclusiones: El campo de representación sobre los humedales y la Ciénaga Grande del Bajo Sinú, evidencia la necesidad de fortalecer procesos significativos de aprendizaje relacionados con el reconocimiento de la importancia ecosistémica que tienen los humedales y ciénagas.
Effects of tailings disposal on the environment: A case study of Nampundwe Mine
Authors: Nalukui S. , Besa B.
Published: November 2024

Globally, the demand for mineral products is ever increasing. Extraction of these mineral resources results in the continuous production of a huge volume of waste material, including tailing dumps. The mass of tailings usually exceeds the actual resource and often contains hazardous contaminants. This study investigated the effects of tailings disposal on soil, water, and air quality in the Nampundwe area. Water, soil, and dust samples were collected from different locations in the surrounding communities. The constituents analysed in the samples included copper, cobalt, iron, sulfate, and silica. According to the results obtained, some seepages occurred from the tailings impoundment to the shallow aquifer in the area. However, the general water quality meets the Zambia Environmental Management Agency (ZEMA) statutory limits. Recorded concentrations of sulfate (1500 mg/l), copper (1.5 mg/l), cobalt (1.0 mg/l), iron (2.0 mg/l), and silica were between 0.003 mg/l and 705 mg/l, which is far below ZEMA's statutory limit. Silica concentration was also evident in the air. The highest concentration recorded was 260 ppcc (particle per cubic centimeter) recorded in July 2019 from the northern direction of the tailings dam. The concentration was below the statutory limit of 350 ppcc. The topsoil from the northern part of the tailings recorded a silica dust concentration of 39.9 ppcc. Iron was evident in the underground soil with a concentration of 8.01 ppcc, cobalt 0.005 ppcc, copper 0.051 ppcc, while sulfate was recorded as 0.41 ppcc.
Management Gaps in the Implementation of Legislation Regulating Derelict and Ownerless Mines in South Africa
Authors: Kuipa E. , Lekunze J.N.
Published: November 2024

Little attention has been paid to the rehabilitation of derelict and ownerless mines in South Africa after their lifespan. This paper aims to explore management gaps in legislation that have resulted in the non-rehabilitation of derelict and ownerless mines in South Africa. There is growing evidence that supports the distressing effects of mining on people living around these mines in the North West Province. This paper was motivated by the current socio-economic status quo of old mining towns, the influx of illegal miners (Zama Zamas), severe environmental damages, and the violence associated with derelict mines. Underpinning this research was an ecosystem approach and integrated resources management principles, which formed the foundation for the decision-making process.The researcher used a mixed-method approach and employed convergent techniques. A semi-structured instrument was used to collect data from 200 respondents. The results indicated that there is a dire need for community-based consultative processes, and an absence of clear guidelines for derelict and ownerless mines to pressure mine management to adhere to rehabilitation standards. Moreover, the mining charter is ambiguous regarding policy implementation, budgetary allocation, and duration of the rehabilitation of these mines. The paper concluded that management challenges associated with derelict mines can be reduced if all stakeholders follow the guidelines as outlined in the environmental legislative framework (NEMA) of South Africa while being open to innovations in line with international best practices. It also contributes towards the development of guidelines for the management and implementation of legislation related to derelict and ownerless mines in South Africa from a philosophical, theoretical, and policy perspective.
Ophidiofauna of Maharashtra: An annotated checklist with new locality records
Authors: Rathod Shradha , Shukla Chaitanya , Satose Varun
Published: November 2024

We present a checklist compiled from resources including peer-reviewed literature, citizen science portals,and internet site records of the ophidiofauna of Maharashtra, India. We documented 80 species (and two valid subspecies)in 38 genera, four species of which are new locality records for the state.
Connection between coping strategies and socio-demographic characteristics of patients diagnosed with lung cancer
Authors:   Tomsk State University, Demchuk Maxim A. ,   Chelyabinsk State University, Pakhomova Yana N. ,   Tomsk State University; Chelyabinsk State University, Tsiring Diana A. ,   Tomsk State University
Published: November 2024

The article examines the connection between coping strategies and sociodemographic characteristics of patients diagnosed with lung cancer. When collecting empirical material, the authors used a questionnaire to obtain data on socio-demographic indicators and the psychodiagnostic survey technique “Methods of Coping Behavior” by R. Lazarus (adapted by T.L. Kryukova). The respondents in this study were 78 patients of the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine, aged from 39 to 80, with malignant neoplasms arising from the epithelium of the tissue of large and medium bronchi, small bronchioles and alveoli. The results of the study are the following. (1) A clear difference between groups of respondents on the basis of “gender” is observed in the coping strategies “confrontational coping” and “positive reappraisal”: the latter is significantly higher in women, while the former in men. The coping strategy “planning to solve a problem”, which is weakly expressed in both men and women, is separately noted; its values are below the norm of the questionnaire. (2) A significant difference between groups of respondents on the basis of “professional status” is observed in the coping strategies “distancing” and “taking responsibility”; among non-working respondents they are much more pronounced. (3) A significant difference between groups of respondents based on age is observed in the coping strategies of “distancing”, “seeking social support”, “planning to solve a problem”, and “positive reappraisal”. Respondents in the 51–60 age group have the highest values of coping “seeking social support”, “planning to solve a problem”, “positive reappraisal”, and the lowest “distancing”. Respondents in the 61–70 age group have the lowest value compared to other groups of respondents and the norm of the questionnaire for the strategy “planning to solve a problem”. Respondents in the 71–80 age group have the highest value for the strategies “seeking social support” and “distancing”, as well as a low value for “planning to solve a problem” in relation to the questionnaire norm. The results obtained can serve as a building block for the development of a scientifically based system of psychological support for both patients and medical personnel working with them at all stages of treatment: from diagnosis to remission.
Explicit theological premises of John Toland’s natural philosophical views on matter and motion
Authors:   University of Tyumen, Yakovlev Valentin V.
Published: November 2024

John Toland (1670–1722) is known as one of the most extraordinary and bright representatives of the early British and certainly of the Western European Enlightenment as a whole. He is recognisable for his controversial religious-philosophical and natural philosophical ideas, usually qualified as deistic, materialistic, pantheistic. The historiography of Toland’s religious-philosophical views is quite extensive. As a rule, Russian and Western specialists emphasise deistic, materialistic-atheistic, pantheistic attributes of Toland’s religious-philosophical ideas, criticism and subversive nature of this ideas – orientation either against any Christian religious and theological doctrines, or against religion in general. The focus of this article is Toland’s natural philosophical views on matter and motion, as expressed in the fourth and fifth letters (addressed to an unnamed Dutch Spinozist) of the work Letters to Serena (1704). In general terms, Toland’s natural philosophical materialism has been and still is evaluated by many Russian and Western specialists only as a forerunner of modern forms of natural-scientific materialist discourse, as a predictable complement to his subversive religious-philosophical ideas. Toland is also predominantly identified as a thinker who sought to liberate natural philosophical views on matter and motion from theological constructs as much as possible. Vivid examples of the embodiment of such and similar interpretative attitudes when reading Toland’s reflections on matter and motion are presented in the studies of B.V. Meerovskiy and J. Brown. However, the author of this article is inclined to take the side of those scholars who, when interpreting Toland’s deistic and materialistic views, prefer to fix the presence of meaning-forming theological foundations in these views in a reasoned and justified manner. Such scholars include, for example, J. Champion and J. R. Wigelsworth. The article reviews a number of fragments of the fourth and fifth letters of Letters to Serena, which contain Toland’s conceptual judgements on matter and motion. The main ideas and propositions of these judgements are also highlighted. This allowed to identify and objectify some basic explicit (outlined directly in Letters) theological premises of Toland’s natural philosophical views on matter and motion.
2018 Sosyal Bilgiler Dersi Öğretim Programında Yer Alan Mekânsal Düşünme Becerileri
Authors: Gönülaçar Hasan , Öztürk Mustafa , Mutlu Neşet
Published: November 2024

Türkiye’de 2000’li yıllardan itibaren öğretim programlarında yapılandırmacı ve aktif öğrenme yaklaşımlarına dayalı olarak beceri öğretimine önem verilmeye başlanmıştır. Özellikle 21. Yüzyıl becerileri kapsamında hem ‘öğrenme ve yenilik becerileri’ hem de ‘bilgi, medya ve teknoloji becerileri’ alt kategorilerine dahil edilebilecek beceriler arasında mekânsal düşünme becerileri de sayılabilir. Bu çalışmada Türkiye’deki akademisyenlerle gerçekleştirilen anket taraması ile toplanan veriler Pearson momentler çarpımı korelasyon katsayısı kullanılarak analiz edilmiştir. Buna göre, sosyal bilgiler dersi öğretim programında (SBDÖP) (2018) yer alan becerilerden sekiz tanesi mekânsal düşünmeyle ilişkilendirilmiştir. Harita okuryazarlığı, konum analizi, mekânı algılama ve gözlem becerileri mekânsal düşünmeyle mükemmel (tam/doğrudan) ilişkili olarak ölçülürken, çevre okuryazarlığı, değişim ve sürekliliği algılama, problem çözme ve tablo-grafik ve diyagram çizme ve yorumlama becerileri yüksek düzeyde (kısmen/dolaylı) ilişkili olarak tespit edilmiştir. SBDÖP (2024)’de yer alan becerilerin mekânsal düşünmeyle ilişkilerinin kurulması hakkında yeni çalışmalar önerilmiştir.
NEWS, SIRS and qSOFA criteria for predicting sepsis and sepsis with high risk of death in emergency room: A comparison study and improved predictive models based on local data from CETAT and MIMIC-IV databases
Authors: Wang Wenwen , Wang Kaipeng , Wang Yueguo , Liu Qingyuan , Sun Jian , Shi Ronghua , Liu Sicheng , Wang Huanli , Yuan Yuan , Xu Jun , Jin Kui , Zhang Yixin
Published: November 2024

Early identification of sepsis in emergency department patients is critical for initiating timely interventions, highlighting the need for effective predictive scoring systems. A retrospective observational study was conducted using data from the CETAT database collected between December 2019 and October 2021. The study evaluated how well the systemic inflammatory response syndrome (SIRS), quick Sepsis-related Organ Failure Assessment (qSOFA), and National Early Warning Score (NEWS) scoring systems, along with logistic regression models, predict sepsis, and high-risk sepsis in emergency department patients. The logistic regression models were further optimized by incorporating additional features based on local data. A total of 12,799 patients were analyzed, including 1360 sepsis cases, of which 373 were classified as high-risk sepsis. The NEWS score demonstrated superior predictive performance compared to qSOFA and SIRS, with an area under the receiver operating characteristic curve (AUC-ROC) of 0.737 (95% confidence interval [CI] 0.72–0.75) for sepsis and 0.653 (95% CI 0.62–0.69) for high risk sepsis . After optimization, the NEWS-based model improved to an AUC-ROC of 0.756 (95% CI 0.74–0.77) for sepsis and 0.718 (95% CI 0.69–0.75) for high-risk sepsis. Further enhancement was observed with the inclusion of additional clinical variables, resulting in AUC-ROC values of 0.834 (95% CI 0.82–0.85) for sepsis and 0.756 (95% CI 0.73–0.78) for high-risk sepsis. Data from the Medical Information Mart for Intensive Care (MIMIC)-IV database, which included sepsis status and relevant variables for SIRS, qSOFA, and NEWS score calculations, confirmed that the optimized NEWS-based model improved the sepsis prediction AUC-ROC from 0.690 (95% CI 0.68–0.70) to 0.708 (95% CI 0.70–0.72), and consistently outperformed qSOFA and SIRS in sepsis prediction.
Sistem tanılama yöntemlerinin zayıf elektrik balıklarının hareket dinamikleri üzerinden karşılaştırılması
Authors: Yılmaz Onurcan , Göksülük Eren Cem , Uyanık İsmail
Published: November 2024

Sistem tanılama, fiziksel sistemlerin matematiksel temsillerini geliştirme veya iyileştirme sürecini ifade eder. Genellikle mühendislik ve kontrol sistemleri alanında kullanılır. Bu çalışmada, zayıf elektrik balıklarının sığınak takibi davranışının hareket dinamiklerini kullanarak sistem tanılama tekniklerini karşılaştırılmalı olarak inceledik. Sistem tanılama yöntemleri iki ana kategoriye ayrılır: Tahmin Hatası Yöntemi ve Alt Uzay Tanılama. Tahmin hatası yöntemi ise yine kendi altında parametrik ve parametrik olmayan olarak ikiye ayrılır. Parametrik olmayan tanılama yöntemleri arasından literatürde sıklıkla kullanılan Frekans Tepki Fonksiyonu, Yinelemeli En Küçük Kareler Metodu, Spektral Analiz Yöntemi ve Wiener-Hopf Metodunu, parametrik yöntemler olarak ise ARX ve ARMAX’ı kullandık. Alt Uzay Tanılama için ise n4sid yöntemini tercih ettik. Elde edilen sonuçlar çeşitli farklara ve dezavantajlara rağmen tüm yöntemlerde kestirim başarımının iyi sonuçlar verdiğini ortaya koymaktadır. Alternatiflerine oranla alt uzay tanılama yöntemi, hem gürültüyü iyi elimine etme özelliği hem de karmaşık sistemleri dahi düşük boyutlu doğrusal sistemlerle ifade edebiliyor olması nedeniyle öne çıkmaktadır.
PROTOCOLO OFICIAL PARA LA FAUNA DEL LPZ-ULPGC v1
Authors: del Laboratorio de Zooarqueología de Las Palmas (LPZ) Grupo
Published: November 2024

This protocol results from our experience in the daily practice of zooarchaeological analysis, which includes the identification ofremains of mammals, reptiles, birds, fish, and insects. With this document, we hope toimprove and facilitate the workduring the different phases that occur from the time the material is recovered from the archaeological site until it reaches our tables at theLaboratorio de Zooarqueologia (LPZ)of the University of Las Palmas de Gran Canaria. This document isa working toolcontaining ourrecommendations. We hope it covers the various aspects and difficulties in collecting and shipping faunal material. The protocol is currently available in English and Spanish If you use the protocol, please cite as:Group of the Zooarqueología Laboratory of Las Palmas (LPZ), (2024). Official protocol for the fauna of the LPZ-ULPGC, version X (version number used), DOI of the protocol. ----------------------------------------------------------------------------------------------------------Este protocolo es fruto de nuestra experiencia en la práctica diaria del análisis zooarqueológico, que integra la identificación de restos de mamíferos, reptiles, aves, peces e insectos. Con este documento esperamos mejorar y facilitar el trabajo durante las distintas fases que se dan desde que el material se recupera en el yacimiento arqueológico hasta que llega a nuestras mesas del Laboratorio de Zooarqueologia (LPZ) de la Universidad de Las Palmas de Gran Canaria. Este documento es una herramienta de trabajo que contiene nuestras recomendaciones. Esperamos cubra los diversos aspectos y dificultades que entraña la recogida y el envío de material faunístico. El protocolo está actualmente disponible en inglés y español Si utiliza el protocolo, cite como: Grupo del Laboratorio de Zooarqueología de las Palmas (LPZ), (2024). Protocolo oficial para la fauna del LPZ-ULPGC, versión X (numero de la versión usada), DOI del protocolo
Real-time PCR amplification and genotyping of the 23s rRNA from Bordetella pertussis using the LightCycler 480 v1
Authors: Bouchez Valérie , Brisse Sylvain , Rodrigues Carla
Published: November 2024

The method is an adaptation for LC480 (version II, Roche) of the one described by Kamachiet al.,EID 2020 (PMID:32946738- Supplementary Materials "Cycleave Real-Time PCR Assay for Detection of the A2047G Mutation"). qPCR targeting 23S rRNA differentiates two alleles of the ribosomal RNA of the 23S subunit ofBordetella pertussis(present in 3 copies per genome). The A2047G mutation distinguishes macrolide-susceptible isolates, with an A at position 2047, from macrolide-resistantBordetella pertussisisolates (MRBP), with a G at position 2047. Real-time amplification is performed from DNA extracted from a respiratory sample that has previously given a positive result for the detection of pertussis toxin (qPCR PTa, 1 copy per genome).Two distinct fluorescent probes are employed: one specific for the susceptible allele (FAM) and the other for the resistant allele (HEX). These probes specifically detect a 123 bp fragment of the 23S ribosomal RNA ofB. pertussisand identify the A2047G mutation. This qPCR is performed only for samples that have given a positive qPCR-PT result, which has a similar analytical sensitivity.
Isolation of nuclei from frozen tissue for snMultiome, snATAC-seq, snRNA-seq, and other epigenomic/transcriptomic assays v2
Authors: Turner Adam , Grandi Fiorella , not provided alia.johnson , Chang Heather , Menon Shreya , Chang Serena , Shah Aayushi , Modi Hailey , not provided courtney.colston , Resnick Vitto , Corces Ryan
Published: November 2024

This protocol enables the isolation of nuclei from frozen tissues for use in downstream single-nucleus Multiome (paired ATAC-seq and RNA-seq) experiments. These nuclei are suitable for use in bulk ATAC-seq, single-nucleus ATAC-seq, single-nucleus RNA-seq, ChIP-seq, HiC/MicroC, among other assays. For single-nucleus Multiome and RNA-seq experiments we recommend addition of RNase inhibitor to the solutions and addition of Triton X-100 and Kollidon VA-64 to the homogenization buffer. These additions were strongly based on nuclei extraction protocols from the McCarroll and Macosko laboratories (dx.doi.org/10.17504/protocols.io.bi62khge). Additions of RNase inhibitor and Kollidon VA-64 are only required for single-nucleus RNA-seq and single-nucleus Multiome workflows.
‘Het zijn onze armen’
Authors: Kotze Este
Published: November 2024

Since its inception in 1824, the Western Cape Synod of the Dutch Reformed Church (DRC) has played a key socio-economic role as provider of a range of poor relief strategies. However, the purpose of these charitable efforts was not solely rooted in theological principles. In the nineteenth and twentieth century South African context, poor relief work carried distinct political undertones, particularly surrounding the so-called ‘poor white problem’. A substantial body of literature has emerged surrounding ‘poor whites’ and the political efforts employed to ‘save’ them in the decades before the implementation of apartheid. While the Church’s poor relief schemes are often mentioned as significant in these studies, the Church’s poor relief systems and their development over time remain understudied. This paper identifies and discusses five distinct phases of development of DRC poor relief strategies over the past two centuries (1824-1860s; c. 1860-1900s; 1910-1940; c. 1940-1980s; and 1990-present) and argues that these stages and the practical implementation of the Church’s poor relief efforts has been notably shaped by the contemporary socio-economic and socio-political zeitgeist in which it was embedded.
recoding of a society
Authors: Pienaar Jacques
Published: November 2024

The undercarriage of Afrikaner nationalist mobilisation was assembled by a small group of language engineers during the opening decades of the twentieth century. Particularly influential within this broad literary project were the Afrikaans clerics who clustered around the Zuid-Afrikaanse Bijbel Vereniging (ZABV, later N.G. Kerk Uitgewers van Suid-Afrika), the official publishing wing of the Dutch Reformed Church (DRC). Propped up by this platform, DRC writers contributed to the linguistic shape of Afrikaans and crucially steered the affixed matter of nation building along a defined religious route in the image of a Christian-National Afrikanerdom. By the start of 1940 a sociological function within the operation of the ZABV lent itself to the nationalist agenda of capturing the consciousness of Afrikaner society. This notably contributed to the creation of an indoctrinated and self-concealed Afrikaner bloc based on the perpetuated myth of an unquestioned and divinely affirmed national uniqueness.
GERMAN ETHNO-CULTURAL BACKGROUND OF SLAVIC PHRASEOLOGY: AN ETYMOLOGICAL COMMENTARY
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Danylenko Liudmyla
Published: November 2024

Background. The article substantiates the etymology of some phrases of Slavic languages associated with German ethnoculture. Compared to lexical etymology, which has reached the Indo-European level of reconstruction, the phraseology of Slavic languages is at the stage of etymologizing individual figurative units. There is a lack of monolingual etymological dictionaries of Slavic phraseology, which could in the future become the basis for multilingual dictionaries. Hence the relevance of our study, which aims to deepen the etymologies of phraseological Germanisms that have been assimilated by Slavic languages to varying degrees. Methods. Descriptive, etymological, and ethnolinguistic methods of analysis are used. Results. On the basis of explanatory and etymological lexicographical sources of the German language, the phraseological germanisms jemandem einen Korb geben, der blaue Montag in the East Slavic, West Slavic and South Slavic groups of Slavic languages, namely Ukrainian, Russian, Belarusian, Czech, Croatian and Slovenian, are studied. Phraseological receptions in Slavic languages are confirmed by ethnocultural data. The German phrase ein Korb geben / ein Korb bekommen has been identified as a genetic source of phraseological calquing in the Slavic languages of the West Slavic and South Slavic groups. For the East Slavic language group, the semantics of the analyzed phrases дати/ дістати гарбуза "give/get the pumpkins" reveals typological rather than genetic kinship. At the same time, we qualify the borrowing of the Ukrainian phrase daty vidkosha to denote any refusal as a Germanic calque through the mediation of Czech and Polish. It is noted that the interpretation of the Czech phrase modré pondělí proposed in the new Academic Dictionary of Modern Czech, in our opinion, cannot have two different meanings, since the expression is originally associated with a specific chronological date. Сonclusions. The study of the genesis of phraseological units of Slavic languages is an urgent and promising task for linguists. The creation of etymological phraseological dictionaries of national languages will help to emphasize the national and universal features of the Slavic worldview in the projection on their history and culture.
UNDICTIONARIED WORDS IN THE WORKS BY N. KAZANZAKIS AND O. ELITIS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Novinska Nataliia
Published: November 2024

Background. The article focuses on the analysis of certain lexical units repeated in the texts of N. Kazantzakis and O. Elytis, which, despite their apparently neological character and absence in major Modern Greek dictionaries, cannot be definitively attributed to the individual author's neology. Neo-Hellenic studies experience a dearth of dictionaries documenting the specific language of major Modern Greek authors and their writings — a lacuna still in need of careful research into vocabularies not yet found in major dictionaries. The tendency of both authors to create new words on the basis of or on the models of archaic (mainly O. Elytis) and dialectal (mostly N. Kazantzakis) words, the misclassification of certain lexemes as authorial neology, the impossibility of lexicographically cover all layers of the Greek lexicon and the versatility of such a concept as "undictionaried words" (out-of-thesaurus, non-dictionary words, words not codified by dictionaries) in Greek scientific literature necessitate further study of the issue. The aim of this research is to focus on the analysis of "non-dictionary words" in the texts of the collections of both authors, to define their poetic function and different shades of meanings in the textual environment. Methods. In the presented analysis descriptive and special research methods were applied: methods of contextual, comparative and structural-semantic analysis, techniques of component and intertextual analysis. The material was selected by the method of continuous sampling; among the lexical units' selection criteria were: stylistic coloring, complete or partial absence of particular lexemes and their components in the major (or newest) dictionaries of Modern Greek language. All the selected lexical material is illustrated by examples from the original texts. Results. The present analysis revealed that some lexical units, which, at first glance, had all the features of the author's neology, on further investigation turned out to be documented earlier - they are present in other texts, articles, collections of literary pieces written by different authors, archives and dictionaries of different periods of Greek language development. Conclusions. As a unique linguistic material, the poems of O. Elytis and N. Kazantzakis have repeatedly become the subject of scientific research, both in terms of direct literary allusions and mythopoetic, but despite the large number of notable works, the scientific interest of researchers has not yet shifted more systematically to the compilation of specialized dictionaries. This issue is particularly acute with regard to the inexhaustible amount of still unexplored linguistic material collected by N. Kazantzakis for his poem 'The Odyssey'.
Remote monitoring of patients with rheumatoid arthritis using a personal messenger
Authors: Prokofeva Yuliya A. , Belenkov Yuri N. , Kozhevnikova Maria V. , Zheleznykh Elena A. , Alborova Zarina V. , Menshikova Irina V.
Published: November 2024

BACKGROUND: Remote medical technologies are a promising way to monitor patients during disease diagnosis, treatment, and subsequent rehabilitation. This paper reviews the clinical implementation and effectiveness of digital tools for remote monitoring and treatment control in patients with rheumatoid arthritis.
AIM: The aim of the study was to evaluate safety, efficacy and technological features of monitoring patients with rheumatoid arthritis using a remote monitoring platform.
MATERIALS AND METHODS: The prospective, non-randomized, controlled study included patients over 18 years of age with moderately to severely active rheumatoid arthritis who were discharged from the hospital for outpatient monitoring. Patients were divided into two groups for remote and in-person monitoring. Data for remote patient monitoring was collected through questionnaires using a Telemedbot Personal Messenger. The authors also used the Health Assessment Questionnaire (HAQ) to assess daily life functioning in patients with rheumatoid arthritis; the European Quality of Life Questionnaire EQ-5D questions to assess patient adherence, duration of morning stiffness, number of painful and swollen joints; and a visual analog scale to assess the overall condition. After 6 months, efficacy of rheumatoid arthritis treatment was assessed in both groups using the DAS28 index.
RESULTS: The remote monitoring program involved 30 patients for 6 months. The in-person monitoring group also included 30 people. After 6 months, patients using the Telemedbot Personal Messenger achieved low rheumatoid arthritis activity and remission more often than the second group (p=0.049). In the remote monitoring group, 9 (30.0%) and 11 (36.7%) patients achieved remission and low disease activity, compared to 3 (10.0%) and 8 (26.7%) patients in the in-person monitoring group. Therefore, 20 (66.7%) people in the remote monitoring group were able to control the disease, while only 11 (36.7%) patients in the in-person monitoring group were able to do so.
CONCLUSIONS: Remote monitoring using the Telemedbot Personal Messenger can be considered a potential way to increase the availability of medical care and efficacy of treatment for rheumatoid arthritis.