bluuebunny/crossref_metadata_2025 huggingface dataset:
Método pilates aplicado ao período gestacional: seus benefícios para o parto natural
Authors: Felix Cinara Araujo , Nascimento Nataly dos Santos , Almeida Sheila Cristina Ribeiro de , Oliveira Naira Patrícia Castro de
Published: November 2021

Objetivo: Discorrer a respeito do método de pilates durante a gestação e os seus benefícios para um parto natural. Metodologia: Trata-se de uma revisão bibliográfico narrativa, realizada através de artigos com base científica de periódicos disponíveis nas bases de dados eletrônicas, como google academico, scielo, livros e revistas, pesquisas que abordam o método pilates no período gestacional que estejam nos anos de 2011 a 2021. Palavras chaves que foram utilizadas para a pesquisa: Método pilates, gestação, parto natural, método pilates, atividades físicas. Resultados: Os resultados que aqui se aplicam, sugerem que a prática de pilates, durante o período gestacional, levando em consideração as dimensões que este exercício atinge, são em suma, determinantes para o processo de parto, ao modo que, atende as necessidades de expansão do corpo, sugeridas ao organismo. Considerações Finais: O pilates, apresenta em seu quadro, uma complexa grade que atende as demandas do organismo de forma ampla, se estende a dores pontuais, e amplas.
Fatores relacionados à iniciação das práticas sexuais precoces na adolescência: uma revisão integrativa
Authors: Araújo Wallacy Jhon Silva , Moura Mariana Isabel Alexandre , Bragagnollo Gabriela Rodrigues , Camargo Rosangela Andrade Aukar de , Monteiro Estela Maria Leite Meirelles
Published: November 2021

Objetivo: identificar evidências científicas acerca dos principais fatores relacionados ao início das práticas sexuais precoces na adolescência. Método: revisão integrativa de artigos publicados em português, inglês ou espanhol, nas bases de dados LILACS, BDENF, MedLine, CINAHL e Web of Science. A questão norteadora foi: quais os principais fatores relacionados com a iniciação das práticas sexuais precoces na adolescência. Foram utilizados os descritores Adolescent, Sexuality, Sexual Behavior, Sexual Intercourse e Coitus, sendo selecionados 38 artigos para análise. Resultados: os resultados deram origem à três classes: Vinculações familiares e entre os pares; Situações de vulnerabilidade e Ações promotoras de saúde. As classes evidenciaram que os fatores relacionados à iniciação das práticas sexuais precoces na adolescência apresentam relações com cenários diversos, capazes de influenciar de forma positiva ou negativa nas decisões do adolescente acerca do início da sua vida sexual. Conclusão: o estudo permitiu uma reflexão crítica acerca dos fatores que contribuem para determinar a iniciação das práticas sexuais precoces na adolescência, como também apreender estratégias protetivas, que concorrem para adiar o início das práticas sexuais.
Oral manifestations detected in COVID-19 patients: an integrative review
Authors: Ramirez Iago , Soares Lélio Fernando Ferreira , Ramos Marcela de Come , Danziger Marcela Filié Haddad
Published: November 2021

The aim of this integrative review consisted of verifying whether the oral manifestations detected in patients diagnosed with COVID-19 are useful in diagnosing the disease, whether they are a manifestation resulting from the disease, or whether there is evidence that there is no correlation between the pathologies. Therefore, articles in the PubMed, Lilacs, Scopus, Science Direct, Web of Science and Embase databases were searched, in addition to the search in gray literature. The terms used in the search were: “COVID-19” or “Sars-Cov-2” or “coronavirus” and “oral conditions” or “oral health” or “oral manifestations” and “diagnosis/complications” or “symptoms”. Thus, 1.305 articles were selected, of which 61 were selected to compose this review. Most of the included studies considered oral symptoms as taste changes, xerostomia and ulcerative lesions in the oral and labial mucosa. All symptoms related to this pathology still need further studies and investigations so that all mechanisms and manifestations related to it are completely elucidated.
Caracterização físico-química de polpa e casca de pitaya ‘Golden’
Authors: Oliveira Bruna Andressa dos Santos , Assis Adriane Marinho de , Schuch Márcia Wulff , Fischer Doralice Lobato de Oliveira , Mattos Marilaine Garcia de , Fischer Lucas de Oliveira , Bergmann Amanda Radmann
Published: November 2021

Com este trabalho, teve-se por objetivo avaliar as características físico-químicas da polpa e da casca de pitaya ‘Golden’. O delineamento experimental foi constituído em esquema unifatorial, com dois níveis (polpa e casca), utilizando dez repetições de um fruto cada. Foram avaliadas as características físico-químicas mencionadas a seguir. Para sólidos solúveis e pH, a polpa e a casca apresentaram valores médios de 8,31 e 4,50 ºbrix e de 4,79 e 5,02 respectivamente. Em relação à acidez titulável, a casca e a polpa apresentaram médias de 0,34 % e 0,18 % de ácido málico. Para a massa média dos frutos, massa da polpa e da casca obteve-se valores médios de 360,45g, 264,04g e 95,63 g, respectivamente. Em relação as variáveis comprimento dos frutos, comprimento da polpa, diâmetro do fruto e diâmetro da polpa, observou-se 138,65mm, 98,67mm, 73,58mm e 63,78mm, respectivamente. Quanto a firmeza da casca e da polpa, o valor médio foi de 9,38 N e 5,89 N, respectivamente. Na espessura da casca, verificou-se média de 2,98 mm. Quanto luminosidade e ângulo hue, observou-se valores médios de 61,68 e 81,79 para casca e polpa, respectivamente. Já para a polpa, os valores médios foram de 35,04 para variável luminosidade e 83,36 para o ângulo hue. Concluiu-se que a polpa e a casca da pitaya ‘Golden’ apresentam características físico-químicas de acordo com a literatura, possuindo potencial tanto para o consumo in natura quanto para a utilização na indústria, bem como proporções de tamanho adequadas para o mercado externo.
O discurso humorístico e a desconstrução de estereótipos sobre a mulher na produção televisiva
Authors: Domingos José , Ferreira Thiago Domingos da Silva
Published: November 2021

Este artigo apresenta uma análise de piadas, cujo objeto discursivo é a mulher, com a finalidade de analisar discursivamente os efeitos de sentido dessa desconstrução no texto das piadas. Para alcançar este objetivo o trabalho está fundamentado na perspectiva da Análise do Discurso francesa, a partir das considerações apoiadas nas noções do discurso, formação discursiva, produção de sentido, estereótipos e a identidade da mulher. A pesquisa está baseada em um estudo bibliográfico de caráter descritivo, por meio da qual será realizada uma análise de cinco piadas veiculadas pelo programa. Verificou-se que as piadas são produzidas com base nos discursos machistas e estereotipados relacionados à identidade e ao papel social atribuído à mulher, a fim de produzir sentidos que desconstruam estas representações. É possível afirmar que o discurso humorístico veiculado pelo programa televisivo “Zorra” funciona no sentido de uma tentativa de desconstrução a respeito da identidade estereotipada da mulher, numa direção diferente dos programas desse gênero televisivo reafirmam estes estereótipos.
Análises físico-químicas e qualidade microbiológica de polpas in natura de buriti (Mauritia flexuosa L.) comercializadas em feiras de Manaus-Amazonas
Authors: Moreno Matheus Nunes , Colares Janderley Almeida , Ramos José Antonio Ferreira , Silva Luiz Henrique Guedes , Marinho Nelly Mara Vinhote , Martim Salomão Rocha
Published: November 2021

A polpa in natura do buriti (Mauritia flexuosa L.) é bastante consumida nos estados da região norte e nordeste do Brasil. Porém, há poucos estudos relacionados ao controle de qualidade desses produtos alimentícios. O objetivo desse estudo foi avaliar as propriedades físico-químicas e a qualidade microbiológica de polpas de buriti comercializadas em Manaus-Amazonas. As amostras foram coletadas em feiras das zonas norte (ZN), sul (ZS), leste (ZL), oeste (ZO), centro-oeste (ZCO) e centro-sul (ZCS) da cidade. As polpas foram avaliadas quanto ao pH, cinzas, acidez titulável expressa em ácido cítrico, sólidos solúveis totais expressos em ºBrix e ratio. Na determinação da qualidade microbiológica foram avaliadas as presenças de coliformes a 45 °C, Escherichia coli, Salmonella sp. e bolores e leveduras. O pH variou de 3,26 a 3,03 e a amostra ZL2 apresentou quantitativo significativo de cinzas (3,0%). Valores de expressivos de sólidos solúveis totais (°Brix) foram determinados nas amostras ZCS1 (4,68) e ZL2 (4,64). A média de acidez expressa em ácido cítrico e do ratio foram de 0,36 g.100-1 e 9,10, respectivamente. A polpas apresentaram elevada contaminação por bolores e leveduras, com contagem significativa (9 x 103 UFC/g) determinada na amostra ZS1. Não foi observado o crescimento de coliformes a 45 °C, E. coli e Salmonella sp. Os resultados obtidos no presente estudo indicam a necessidade de melhorias no controle de qualidade das polpas in natura comercializadas nas feiras da capital amazonense.
Importância do acompanhamento e das intervenções relacionadas ao novo Corona Vírus (Sars-Cov-2), desde sua descoberta até os dias atuais – uma revisão da literatura
Authors: Silva Bruno Edvaldo da , Silva Jardeilson José da , Silva Lidiane Gomes da
Published: November 2021

Em 1965 o primeiro coronavírus humano (HCoV) foi identificado. Nos anos seguintes, tipos de cepas foram o foco de diversas pesquisas, até surgir o Coronavírus que ocasionou uma síndrome aguda grave altamente patogênica em 2002 a 2003. O SARS-CoV-2 (sigla do inglês que significa coronavírus 2 da síndrome respiratória aguda grave) identificado em dezembro de 2019 é o agente etiológico da doença causada pelo Coronavírus 2019 (COVID-19). O alvo primordial do SARS-CoV-2 é o trato respiratório e, sua presença no local, causa inflamações que podem ocasionar sinais clínicos. Esse vírus é capaz de infectar vários hospedeiros, causando uma variedade de doenças hepáticas, entéricas, respiratórias, e do sistema nervoso central. O presente estudo objetivou realizar uma revisão da literatura científica para identificar e apontar a importância do acompanhamento e das intervenções nos cuidados com os pacientes, devido as novas mutações do novo Coronavírus. Para realização da pesquisa, as palavras-chaves, COVID-19, novo coronavírus, acompanhamento, mutações e intervenções foram utilizados. Tais palavras chaves foram associadas utilizando o operador booleano AND. Foram incluídos 11 artigos nos resultados que caracterizavam o tema de estudo. Na análise dos artigos foi possível identificar que, a COVID-19 vem sendo disseminada por vários países desde 2019, sendo classificado como Pandemia pela OMS. Ademais, observa-se que autoridades de saúde pública tomaram medidas protetivas para acompanhar os pacientes com COVID-19, além de realizar o acompanhamento do desenvolvimento de novas variantes do vírus através do sequenciamento genômico. Além disso, vacinas têm sido desenvolvidas, com finalidade de evitar disseminação do vírus, e sinais clínicos graves em pessoas contaminadas. Em breve, todos estarão imunizados contra o Novo coronavírus e as variantes da SARS-CoV-2, frisando a importância e necessidade de estudos para compreensão do vírus em sua forma, estrutura e possíveis mutações.
Diferenciação de diagnósticos e tratamentos entre alergia e intolerância ao leite
Authors: Alves Alex Santos , Lima Nádia Cristina de , Martins Guilherme Bandeira Candido
Published: November 2021

A Alergia a Proteína do Leite de Vaca (APLV) é uma alergia alimentar, mais frequente em crianças e é desencadeada por uma resposta imunológica. A Intolerância à Lactose (IL) está relacionada com a má absorção da lactose devido a inatividade ou deficiência da enzima lactose. A fim de resguardar a saúde da população, principalmente as crianças, é objetivado demonstrar a importância do diagnóstico da IL e da APLV, a diferenciação entre as condições e seus diagnósticos e tratamento. O diagnóstico da APLV é realizado através de anamnese, teste físico, pesquisa de anticorpos e o teste de provocação oral. O tratamento primário é a exclusão do consumo do leite de vaca, podendo incluir o uso de corticoides e anti-histamínicos. O diagnóstico da IL pode ser realizado por teste de tolerância e medição da atividade da lactase. O tratamento da IL é a suspensão do consumo do leite e/ou a terapia de reposição da enzima lactase. O método Food Detective não é adequado para diagnosticas APLV ou IL. O diagnóstico das duas condições deve ser realizado com cautela, visto que a exclusão do leite da alimentação pode interferir nos níveis de nutrientes necessários, principalmente nas crianças.
Interprofessional health education teacher training at the University of Chile
Authors: Barrios Mónica Espinoza , Torres Sandra Oyarzo
Published: November 2021

The first interprofessional course that included students in the 8 undergraduate health programs at the Faculty of Medicine of the University of Chile was implemented in 2015. For the 700 students, 35 teachers were trained as facilitators. The use of several strategies to train facilitators in interprofessional health education, such as working in small groups, role-playing, case analysis, personal development workshops with experts’ participation, teamwork skills, feedback, videos, and reading articles, proved to be helpful. Facilitators highlighted the use of syllabi as a fundamental tool for teaching and coordination. This guide describes the experience of interprofessional health education teacher training from 2015 to 2019, highlighting the following lessons learned: the importance of support from university authorities, raising faculty awareness about interprofessional health education and collaborative practice, creating a teachers’ coordination team including representatives from all health programs, and ongoing monitoring and feedback from participants.
Soft corals and microplastics interaction: first evidence in the alcyonacean species Coelogorgia palmosa
Authors: Vencato S , Isa V , Seveso D , Saliu F , Galli P , Lavorano S , Montano S
Published: November 2021

Microplastics pollution differentially impacts coral reef systems, by threatening corals physically, through physiological distress and by increasing diseases. However, most of the studies to date have focused on scleractinian corals. The present work reports for the first time the patterns of microplastic ingestion and adhesion by the alcyonacean Coelogorgia palmosa. Feeding and adhesion tests were carried out with various concentrations of polyethylene microbeads. Results showed a wide range of surface adhesion, ranging from 3 to 1573 microbeads per coral fragment, suggesting that adhesion driven by mucus is the main mechanism of microplastic trapping. Polyethylene was ingested by 60% of coral fragments, and the average number of ingested microbeads was much lower compared to scleractinian corals. Considering the ecological importance of soft corals in coral reef ecosystems, specific attention regarding microplastic pollution effects on this taxon is recommended.
Low occurrence of ranavirus in the Prairie Pothole Region of Montana and North Dakota (USA) contrasts with prior surveys
Authors: Tornabene BJ , Crespi EJ , Traversari BA , Stemp KM , Breuner CW , Goldberg CS , Hossack BR
Published: November 2021

Ranaviruses are emerging pathogens that have caused mortality events in amphibians worldwide. Despite the negative effects of ranaviruses on amphibian populations, monitoring efforts are still lacking in many areas, including in the Prairie Pothole Region (PPR) of North America. Some PPR wetlands in Montana and North Dakota (USA) have been contaminated by energy-related saline wastewaters, and increased salinity has been linked to greater severity of ranavirus infections. In 2017, we tested tissues from larvae collected at 7 wetlands that ranged in salinity from 26 to 4103 mg Cl l-1. In 2019, we used environmental DNA (eDNA) to test for ranaviruses in 30 wetlands that ranged in salinity from 26 to 11754 mg Cl l-1. A previous study (2013-2014) found that ranavirus-infected amphibians were common across North Dakota, including in some wetlands near our study area. Overall, only 1 larva tested positive for ranavirus infection, and we did not detect ranavirus in any eDNA samples. There are several potential reasons why we found so little evidence of ranaviruses, including low larval sample sizes, mismatch between sampling and disease occurrence, larger pore size of our eDNA filters, temporal variation in outbreaks, low host abundance, or low occurrence or prevalence of ranaviruses in the wetlands we sampled. We suggest future monitoring efforts be conducted to better understand the occurrence and prevalence of ranaviruses within the PPR.
STRUCTURAL SETTING AND HYDROCARBON POTENTIAL OF KHARITE-NUQRA-KOMOMBO RIFT BASINS, SOUTH EGYPT: A PROSPECTIVE APPROACH
Authors: A Mostafa , A Sehim , A El Barkooky , M Hammed
Published: November 2021

— The sedimentary basins of Kharite, Nuqra,
and Komombo are outlined with the potential geophysical
data where the southern N-S Egyptian Nile course
separates Nuqra and Kharit as the East Nile basins. Two
commercial discoveries of Al Barka and West El Barka oil
fields have been declared in the West Nile basin of
Komombo. This work presents our insights on the
structural setting and hydrocarbon system of these basins
through our integrating results in form of interpreted
seismic profiles and structural mapping on the different
horizons, 1D basin modeling, geochemistry, and geologic
maps based on high-resolution satellite images.
Structurally, these rift basins are developed as NWtrending asymmetric fault-bounded half-grabens (oblique
to the Red Sea trend) through the reactivation of a major
Precambrian Pan African tectonic zone by the Neocomian
extensional tectonics. The high potential source rock with
up to 7wt. % TOC of kerogen II are proved in the
Komombo basin. The seismic and drilling results show
Neocomian-Barremian maximum subsidence and the
possible occurrence of similar Neocomian source rocks in
the eastern Nile basins. Additionally, the convenient clastic
reservoir rocks occurred in the entire stratigraphic
succession and seal capacity in the upper interval of
Senonian-Paleocene. Good opportunities for hydrocarbon
structural trapping take place in form of rotated fault
blocks by the Early Cretaceous extensional rift and mildly
inverted structures by a long span of Late Cretaceous to
post-Early Eocene Syrian Arc compression in South Egypt.
These elements were verified by Al Baraka discovery and
present a promising play concept for hydrocarbon
potential in the Kharit and Nuqra basins. The geochemical
data indicate different basins exhumation and maturation
levels, as the 0.5% calculated vitrinite reflectance "Ro"
values occur at the depths of 1200ft and 2100ft in Nuqra
and Komombo basins, respectively
SIMULATION OF DYNAMIC EVENT OF IMPACT USING EXPLICIT 3D FEM MODEL AND VALIDATION BY EXPERIMENT AND CONTACT MODELS
Authors: Mallikarjuna Akshay , Marghitu Dan , Raju P.K.
Published: November 2021

— In this study, an optimized method to simulate the
dynamic 3D event of the impact of a rod with a flat surface
has been presented. Unlike the 2D FEM based contact
models, in this study both the bodies undergoing the impact
are considered elastic(deformable) and simulation is the
dynamic event of the impact, instead of predefined 2D
symmetric contact analysis. Prominent contact models and
plasticity models to define material properties in ANSYS
are reviewed. Experimentation results of normal and
oblique impact of the rod for different rods provided the
coefficient of restitution. Experimental results of
permanent deformation on the base for different impact
velocity is derived out of a prominent impact study. The
simulation results are in co-relation with experiment and
both indentation and flattening models on the coefficient of
restitution (COR) and permanent deformation of the base
and rod after the impact. Thus, the presented 3D Explicit
Dynamic simulation of impact is validated to analyze the
impact behavior of the 2 bodies without any predefined
assumptions with respect to boundary conditions or
material properties.
HUMAN INTELLIGENCE ANALYSIS AND DETECTING SCENARIOS USING ARTIFICIAL INTELLIGENCE BASED ON HUMAN COMPUTER INTERACTION IN EDUCATION SYSTEM
Authors: Hatalge Akash Dilip , F. Momin Dr. Bashirahamad
Published: November 2021

It is different from the situation that people
have just experienced normal information from general
websites. Users of an educational web application for
teaching as faculty and students need more
communication with each other. That means they
desperately need to communicate with mediators like
computers and other resources. Therefore, research
conducted on the design of human computers takes a huge
amount of value. In this paper, a user model of
Educational Web Application is concluded. The Web
Application includes that Facial Recognition for login,
attendance and to see the student’s behavior in the
classroom by continuous monitoring. Knowledge trees and
tests are designed for better understanding and to improve
yourself in particular or all subjects. The aim of the paper
is to develop a system to manage and maintain
sentiments and detecting student’s behavior by humancomputer interaction. We propose a software framework
to monitor boundaries, analyze them and support users to
see how they interact in conversations or lectures and
manage their emotions.
A REVIEW OF MACHINE LEARNING AND ITS APPLICATIONS
Authors: Bari Vishal , Gaikwad Dr.M.S , Babar Dr. Rajendra
Published: November 2021

Today, huge amounts of data are available
everywhere. Therefore, analyzing this data is very
important to derive useful information from it and
develop an algorithm based on this analysis. This
can be achieved through data mining and machine
learning. Machine learning is an essential part of
artificial intelligence used to design algorithms
based on data trends and past relationships between
data. Machine learning is used in a variety of areas
such as bioinformatics, intrusion detection,
information retrieval, games, marketing, malware
detection, and image decoding. This paper shows the
work of various authors in the field of machine
learning in various application areas.
AN ASSESSMENT AND MODELING OF CRITICAL SUCCESS FACTORS OF INDIAN AGRICULTURE USING INTERPRETIVE STRUCTURAL MODELLING AND MICMAC ANALYSIS
Authors: Dave Bhavesh , Sukhwani Dr. Vijay Kumar
Published: November 2021

— The aim of this paper is to analyse the
most practiced Critical Success Factors (CSFs) for
Indian agriculture. India is an agricultural
country. Approximately three-fourth population
of India is primarily dependent on agriculture for
their livelihood. Therefore, any improvement in
agriculture can provide impetus to Indian
economy. The success of this approach is rooted
on the understanding of different enablers of
Indian agriculture. The most commonly accepted
CSFs for Indian agriculture were indentified from
the literature. Then by agricultural expert’s
opinion, interactions among those CSFs have been
studied using Interpretive Structural Modeling
(ISM). The findings through MICMAC analysis
implied that most of the CSFs are classified as
linkage variables and remaining are classified as
Independent variables. The developed model
provides a road map that assists practitioners to
understand the process through which CSFs are
practiced in a certain enterprise.
IDENTIFICATION OF COMPONENTS FOR THE EVALUATION OF FUNDED RESEARCH PROJECT: A SYSTEMATIC LITERATURE REVIEW
Authors: Chikkaballapur Balaji Kruthi , Gopal Poorvika , Srinivasaiah Rashmi , Renuka Swamy Devappa
Published: November 2021

The purpose of this paper is to identify
different components that can help to determine
the effect of study findings and to identify different
methodologies as well. To clarify the extent of the
study on the impact assessment of funded
initiatives in various countries, a systematic
literature review is carried out.
Methodology: It is important to consider the effects
of scientific findings to achieve value for the
resources spent in science and technology. A
systematic literature review (SLR) is carried out to
gain a detailed understanding of the different
literature available in the area of assessment of the
search results of the projects funded. A total of 72
papers are collected from Google scholars to
perform the SRL, which are screened according to
the requirements for inclusion and exclusion.
Further 20 papers, primarily focusing on two study
fields, namely the academic and health care
industries, are accepted. The 20 papers chosen are
mapped accordingly based on the market, country
of origin, variables, and approaches used by
different authors.
Conclusion: To determine the most significant
variables commonly used by numerous writers in
their studies, a systematic literature review is
undertaken. The methodologies used by writers in
their studies are also identified in this study. This
paper can also be used by other researchers to
describe in their studies the components and
methodologies commonly used.
Originality/Value: The current research assists
policymakers in making decisions on which
components to examine when assessing funded
initiatives that improve the effects, quality, and
productivity in the higher educational sectors, and
there has been relatively limited research in this
field.
FACIAL RECOGNITON BASED DOOR LOCKING AND UNLOCKING MECHANISM BASED ON IOT
Authors: Parasar Purobi , Deka Hirockjyoti , Saikia Bishal , Anjan Chutia Nilabh , Bikash Acharjee Dr. Purnendu
Published: November 2021

Now a days Security Has Become
an Important Issue to Be Resolved. So, We Are
Solving That Matter by Using Updated Technology. This Project “Face Recognition Based Door
Unlocking System” deals with The Conception to
Protect Locking Mechanism Utilizing IoT for
Door Unlocking Process to Give Essential Security
to Our House, Bank Lockers and others. In This
Project We Look into the Accuracy of The Face
Recognition Algorithms Using OpenCV And Python Computer Language. Local Binary Pattern
Histogram Algorithm Is Used for Face Recognition. Training and Identification Is Done in Raspberry pi.
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ANALYSIS OF PHENAZINEAZO-1-NAPHTHOL PRODUCED FROM PHENAZINE-1- CARBOXYLIC ACID ISOLATED FROM PSEUDOMONAS AERUGINOSA
Authors: I.C. Onunkwo , I.O. Okerulu , O.J. Okonkwo
Published: November 2021

The search for effective antibiotics
continues among scientists as more resistant
pathogenic microorganisms evolve, and some
already existing antibiotics used in treatment of
infections are gradually becoming less effective
against the pathogens causing the infections thus,
making life unbearable to their hosts. Phenazines
are para diazine with annular two nitrogen atoms
at 1,4 positions joined to two phenyl group in a side
by side pattern. The derivatives of the compound
are primarily produced from microorganisms and
can also be synthesized, example of this is
phenazine-1-carboxylic acid (PCA). In the present
study, phenazine-1-carboxylic acid was
biosynthesized from Pseudomonas aeruginosa
isolated from soil. Subsequently, phenazineazo-1-
naphthol was synthesized from the produced
phenazine-1-carboxylic acid following amidation
with Ammonium carbonate and Hoffmann
degradation reactions to reduce the compound to
phenazineamine under reflux condition of 50 °C
before diazotization and coupling with 1-naphthol.
The results obtained from the UV-vis, IR and NMR
spectra were able to elucidate the important peaks
in the compound at reasonable extents. The
concentrations of 50 ?g/mL, 100 ?g/mL, 150
?g/mL, 200 ?g/mL, 30 ?g/mL Augmentin (Au,
control drug), 30 ?g/mL Oflocitoxin (OFX, control
drug) and raw sample of the compound were able
to inhibit Staphylococcus aureus and Escherichia
coli at some millimeter ranges while Aspergillus
fumigatus was inhibited by all the sample
concentrations but resisted 30 ?g/mL Augmentin
(Au) and Oflocitoxin (OFX) control drugs from the
antimicrobial analysis carried out. In general, the
compound was active against the organisms when
compared to the concentrations of control
antibiotic drugs used. The minimum inhibitory
concentration of the compound was estimated at 50
?g/mL concentrations.
STABILITY AND CONTROL ASPECTS OF MICRO-GRID ARCHITECTURES OF WIND POWER SYSTEM
Authors: Aamir Khan Muhammad , Zahid Huzaifa , Faheem Anwar Muhammad , Mehmood Sajid , Zulqarnain Muhammad , Naveed Muhammad
Published: November 2021

Voltage unstability nowadays is a serious
problem, Present day electric power utilities are
confronting numerous difficulties because of regularly
expanding multifaceted nature in their task and structure.
One issue that got wide consideration is voltage instability.
One of the significant reasons for voltage instability in the
power framework is with its receptive power limit. It can
cause different damages to our electrical appliances, and
therefore the approach used in this research is for the
benefit for these dangerous phenomenon. In this research
Voltage control single phase STATCOM using different
sources such as Photovoltaic Cell, DC generator, battery
and WAPDA used, in such a way to have a backup voltage
source to have an untriptable supply, in case of less than 9
V the relay converter used the DC generator as back end
source. It is a controller based system, controller on the
basis of voltages changes the source to PV to DC and DC
generator to Battery depends upon the voltages. Inverter is
used which take input of 12 V that are controlled by relay
in case of PV it is stabilized by buck converter. 1kVA
Transformer then sets the voltage to 230V single phase,
STATCOM is used after transformer to set the voltage at
230 V Power and Voltage monitoring system is used to
check power and voltages at every point.
A RESEARCH PROPOSAL FOR THE PROJECT OF IMPLEMENTING ECG TRACKING SENSOR ALARMS IN STREET LIGHT USING SUSTAINABLY PRODUCED ELECTRICITY
Authors: Rana Anshika
Published: November 2021

The main focus of implementing ECG tracking
sensor alarms in street lights using sustainably produced
light is to mainframe the idea of using ecofriendly ways to
produce electricity as well as enhancing the road security.
The idea is to motivate people to enhance physical activities
of all ages and using their work force to produce electric
power which eventually will contribute to better AI-assisted
pedestrian safety system.
A dilemma a régi: biliaris a pancreatitis, vagy nem? : A pancreatitis differenciáldiagnosztikai nehézségei terhességben
Authors: Bősze Zsófia , Bor Renáta , Szepes Zoltán
Published: November 2021

Az epeköves megbetegedés szempontjából a terhesség önálló rizikótényezőként szerepel. A terhesség alatti epeköves betegségek aránya 0,05-8% között változhat. A cholecystitisek 27-36%-ában kerül sor műtétre, míg annak hiányában a relapszusok aránya akár a 70%-ot is elérheti a populációban. Akut pancreatitisben nehézséget okozhat az etiológia pontos tisztázása, és ebben limitáló tényezőként léphet fel maga a graviditás is. Egy 30 éves, 12 hetes gravida esetén keresztül mutatjuk be, milyen nehézségek adódhatnak biliaris pancreatitisben a terhesség során, és elemezzük, milyen modalitásokkal lehet megfelelően alátámasztani a diagnózist, kiemelve az endoszkópos ultrahang használatát.
DECODING THE STAR OF BETHLEHEM : An analytical scientific approach to the unprecedented astronomical phenomenon that was finally the “Bethlehem Star”
Authors: Sofias Sotiris
Published: November 2021

We all wonder what happened that marked the era of the coming of Christ, what unusual phenomenon urged the Magi and drew their route west bound. Was it all fiction, concocted by the Apostles to bestow sanctity to the birth of Jesus, or was it in fact a celestial event, a rare planetary occurrence that led the Magi on their journey, as described in the Gospels.
Tasarım Kararlarının Deprem Güvenli Olmaya Etkisi
Authors: Okutucu Fikret
Published: November 2021

Yıkıcı depremlerde hasar görmüş binaların incelenmesi, yapının formu ile deprem hasarları arasında sıkı bir ilişki olduğunu göstermiştir. Ülkemizdeki yıkıcı depremlerin büyük çoğunluğu doğrultu atımlı faylar olan Kuzey Anadolu ve Doğu Anadolu Fay zonlarındadır. Yazarın gözlemine dayalı bir tespit olarak; doğrultu atımlı fayların oluşturduğu depremlerde binanın uzun kenarının depremin atım yönüne paralel olması binaya ek dayanım kazandırırken, dik olması daha az dayanımlı olmasına neden olmaktadır. Bu ilkeye ve önlemine dikkat edildiğinde ekonomik, uzun ömürlü / ekolojik olan binalar elde edilmesinin yanı sıra mimari tasarım ilkeleriyle deprem güvenli bina üretimine gerçek bir katkı verilmiş olacaktır.
Towards a Positive Welfare Protocol for Cattle: A Critical Review of Indicators and Suggestion of How We Might Proceed
Authors: Keeling Linda J. , Winckler Christoph , Hintze Sara , Forkman Björn
Published: November 2021

Current animal welfare protocols focus on demonstrating the absence (or at least low levels) of indicators of poor welfare, potentially creating a mismatch between what is expected by society (an assurance of good animal welfare) and what is actually being delivered (an assurance of the absence of welfare problems). This paper explores how far we have come, and what work still needs to be done, if we are to develop a protocol for use on commercial dairy farms where the aim is to demonstrate the presence of positive welfare. Following conceptual considerations around a perceived “ideal” protocol, we propose that a future protocol should be constructed (i) of animal-based measures, (ii) of indicators of affective state, and (iii) be structured according to indicators of short-term emotion, medium-term moods and long-term cumulative assessment of negative and positive experiences of an animal's life until now (in contrast to the current focus on indicators that represent different domains/criteria of welfare). These three conditions imposed the overall structure within which we selected our indicators. The paper includes a critical review of the literature on potential indicators of positive affective states in cattle. Based on evidence about the validity and reliability of the different indicators, we select ear position, play, allogrooming, brush use and QBA as candidate indicators that we suggest could form a prototype positive welfare protocol. We emphasise that this prototype protocol has not been tested in practice and so it is perhaps not the protocol itself that is the main outcome of this paper, but the process of trying to develop it. In a final section of this paper, we reflect on some of the lessons learnt from this exercise and speculate on future perspectives. For example, while we consider we have moved towards a prototype positive welfare protocol for short-term affective states, future research energy should be directed towards valid indicators for the medium and long-term.
Analysis of MicroRNA Profile Alterations in Extracellular Vesicles From Mesenchymal Stromal Cells Overexpressing Stem Cell Factor
Authors: Zubkova Ekaterina , Evtushenko Evgeniy , Beloglazova Irina , Osmak German , Koshkin Phillip , Moschenko Alexander , Menshikov Mikhail , Parfyonova Yelena
Published: November 2021

Mesenchymal stem/stromal cells (MSCs) represent a promising tool to treat cardiovascular diseases. One mode of action through which MSCs exert their protective effects is secretion of extracellular vesicles (EVs). Recently, we demonstrated that rat adipose-derived MSC-overexpressing stem cell factor (SCF) can induce endogenous regenerative processes and improve cardiac function. In the present work, we isolated EVs from intact, GFP- or SCF-overexpressing rat MSC and analyzed microarray datasets of their miRNA cargo. We uncovered a total of 95 differentially expressed miRNAs. We did not observe significant differences between EVs from GFP-MSC and SCF-MSC that may indicate intrinsic changes in MSC after viral transduction. About 80 miRNAs were downregulated in EVs from both SCF- or GFP-MSC. We assembled the miRNA-based network and found several nodes of target genes among which Vim Sept3 and Vsnl1 are involved in regulation of cellular migration that is consistent with our previous EVs data. Topological analyses of the network also revealed that among the downregulated miRNA-rno-miRNA-128-3p that regulates plenty of targets is presumably associated with chemokine signaling pathways. Overall, our data suggest that genetic modification of MSC has a great impact on their miRNA composition and provide novel insights into the regulatory networks underlying EV effects.
A Novel Pyroptosis-related Prognostic Model for Hepatocellular Carcinoma
Authors: Wu Qianqian , Jiang Sutian , Cheng Tong , Xu Manyu , Lu Bing
Published: November 2021

Hepatocellular carcinoma (HCC) is the second most lethal malignant tumor because of its significant heterogeneity and complicated molecular pathogenesis. Novel prognostic biomarkers are urgently needed because no effective and reliable prognostic biomarkers currently exist for HCC patients. Increasing evidence has revealed that pyroptosis plays a role in the occurrence and progression of malignant tumors. However, the relationship between pyroptosis-related genes (PRGs) and HCC patient prognosis remains unclear. In this study, 57 PRGs were obtained from previous studies and GeneCards. The gene expression profiles and clinical data of HCC patients were acquired from public data portals. Least absolute shrinkage and selection operator (LASSO) Cox regression analysis was performed to establish a risk model using TCGA data. Additionally, the risk model was further validated in an independent ICGC dataset. Our results showed that 39 PRGs were significantly differentially expressed between tumor and normal liver tissues in the TCGA cohort. Functional analysis confirmed that these PRGs were enriched in pyroptosis-related pathways. According to univariate Cox regression analysis, 14 differentially expressed PRGs were correlated with the prognosis of HCC patients in the TCGA cohort. A risk model integrating two PRGs was constructed to classify the patients into different risk groups. Poor overall survival was observed in the high-risk group of both TCGA (p < 0.001) and ICGC (p < 0.001) patients. Receiver operating characteristic curves demonstrated the accuracy of the model. Furthermore, the risk score was confirmed as an independent prognostic indicator via multivariate Cox regression analysis (TCGA cohort: HR = 3.346, p < 0.001; ICGC cohort: HR = 3.699, p < 0.001). Moreover, the single-sample gene set enrichment analysis revealed different immune statuses between high- and low-risk groups. In conclusion, our new pyroptosis-related risk model has potential application in predicting the prognosis of HCC patients.
Enabling Technology for Supramolecular Chemistry
Authors: Ollerton Katie , Greenaway Rebecca L. , Slater Anna G.
Published: November 2021

Supramolecular materials–materials that exploit non-covalent interactions–are increasing in structural complexity, selectivity, function, stability, and scalability, but their use in applications has been comparatively limited. In this Minireview, we summarize the opportunities presented by enabling technology–flow chemistry, high-throughput screening, and automation–to wield greater control over the processes in supramolecular chemistry and accelerate the discovery and use of self-assembled systems. Finally, we give an outlook for how these tools could transform the future of the field.
Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
Authors: Burster Timo , Mustafa Zhadyra , Myrzakhmetova Dinara , Zhanapiya Anuar , Zimecki Michal
Published: November 2021

During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.
Obvious Surface States Connecting to the Projected Triple Points in NaCl’s Phonon Dispersion
Authors: Zhang Li , Fang Fang , Cheng Lixin , Lin Huiming , Wang Kai
Published: November 2021

With the development of computer technology and theoretical chemistry, the speed and accuracy of first-principles calculations have significantly improved. Using first-principles calculations to predict new topological materials is a hot research topic in theoretical and computational chemistry. In this work, we focus on a well-known material, sodium chloride (NaCl), and propose that the triple point (TP), quadratic contact triple point (QCTP), linear and quadratic nodal lines can be found in the phonon dispersion of NaCl with Fm3¯ m type structure. More importantly, we propose that the clear surface states connected to the projected TP and QCTP are visible on the (001) surface. It is hoped that further experimental investigation and verification for these properties as mentioned above.
codY and pdhA Expression Is Induced in Staphylococcus epidermidis Biofilm and Planktonic Populations With Higher Proportions of Viable but Non-Culturable Cells
Authors: Gaio Vânia , Lopes Nathalie , Cerca Nuno , França Angela
Published: November 2021

Staphylococcus epidermidis biofilm cells can enter a physiological state known as viable but non-culturable (VBNC), where, despite being alive, they do not grow in conventional laboratory media. As such, the presence of VBNC cells impacts the diagnosis of S. epidermidis biofilm-associated infections. Previous transcriptomics analysis of S. epidermidis strain 9142 biofilms with higher proportions of VBNC cells suggested that the genes pdhA, codY and mazEF could be involved in the induction of the VBNC state. However, it was previously demonstrated that VBNC induction is strain-dependent. To properly assess the role of these genes in VBNC induction, the construction of mutant strains is necessary. Thus, herein, we assessed if VBNC cells could be induced in strain 1457, a strain amenable to genetic manipulation, and if the previously identified genes were involved in the modulation of the VBNC state in this strain. Furthermore, we evaluated the formation of VBNC cells on planktonic cultures. Our results showed that despite being commonly associated with biofilms, the proportion of VBNC cells can be modulated in both biofilm and planktonic cultures and that the expression of codY and pdhA was upregulated under VBNC inducing conditions in both phenotypes. Overall, our study revealed that the formation of VBNC cells in S. epidermidis is independent of the mode of growth and that the genes codY and pdhA seem to be relevant for the regulation of this physiological condition.
Characterization of Awp14, A Novel Cluster III Adhesin Identified in a High Biofilm-Forming Candida glabrata Isolate
Authors: Fernández-Pereira Jordan , Alvarado María , Gómez-Molero Emilia , Dekker Henk L. , Blázquez-Muñoz María Teresa , Eraso Elena , Bader Oliver , de Groot Piet W. J.
Published: November 2021

Candida glabrata is among the most prevalent causes of candidiasis. Unlike Candida albicans, it is not capable of changing morphology between yeast and hyphal forms but instead has developed other virulence factors. An important feature is its unprecedented large repertoire of predicted cell wall adhesins, which are thought to enable adherence to a variety of surfaces under different conditions. Here, we analyzed the wall proteome of PEU1221, a high biofilm-forming clinical strain isolated from an infected central venous catheter, under biofilm-forming conditions. This isolate shows increased incorporation of putative adhesins, including eight proteins that were not detected in walls of reference strain ATCC 2001, and of which Epa22, Awp14, and Awp2e were identified for the first time. The proteomics data suggest that cluster III adhesin Awp14 is relatively abundant in PEU1221. Phenotypic studies with awp14Δ deletion mutants showed that Awp14 is not responsible for the high biofilm formation of PEU1221 onto polystyrene. However, awp14Δ mutant cells in PEU1221 background showed a slightly diminished binding to chitin and seemed to sediment slightly slower than the parental strain suggesting implication in fungal cell-cell interactions. By structural modeling, we further demonstrate similarity between the ligand-binding domains of cluster III adhesin Awp14 and those of cluster V and VI adhesins. In conclusion, our work confirms the increased incorporation of putative adhesins, such as Awp14, in high biofilm-forming isolates, and contributes to decipher the precise role of these proteins in the establishment of C. glabrata infections.
Long-Term Abnormalities of Lipid Profile After a Single Episode of Sepsis
Authors: Felici Nicholas , Liu Da , Maret Josh , Restrepo Mariana , Borovskiy Yuliya , Hajj Jihane , Chung Wesley , Laudanski Krzysztof
Published: November 2021

Background: Acute disturbances of the lipid profile are commonplace during acute sepsis episode. However, their long-term persistence has not to be investigated despite pivotal role of dyslipidemia in several comorbidities excessively noted in sepsis survivors (stroke, cardiomyopathy).

Methods: A total of 9,861 individuals hospitalized for a singular episode of sepsis between 2009 and 2019 were identified from electronic medical records. Lab measurements of total cholesterol (Tchol), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL), triglycerides (TG), lipoprotein(a) [Lp (a)], apolipoprotein B (ApoB), and C-reactive protein (CRP). The data were examined as baseline values before sepsis, during hospitalization, and <3 months, 3–6 months, 6–12 months, 1–2 years, and more than 2 years from initial sepsis.

Results: Significant reductions in HDL-c (HDLbaseline = 44.06 vs. HDLsepsis = 28.2; U = −37.79, p < 0.0001, Cohen's d = 0.22) and LDL-c serum levels were observed during and up to three months post sepsis, with females much less affected. In contrast, male subjects had derangement in HDL present for up to two years after a singular septic episode. Total cholesterol levels were slightly yet significantly elevated for up to two years after sepsis. TG were elevated up to one year [TGbaseline = 128.26 vs. TGsepsis = 170.27, t(8255) = −21.33, p < 0.0001, Cohen's d = 0.49] and normalized. Lp(a) was elevated up to two years after initial episode [Lp(a)baseline = 24.6 ± 16.06; Lp(a)sepsis−2year = 8.25 ± 5.17; Lp(a)morethan2years = 61.4 ± 40.1; ANOVA F(2, 24) = 7.39; p = 0.0032]. Response to statin therapy was blunted in sepsis survivors for several years after sepsis resolution. Significant drop-out in prescription of statins and niacin after sepsis was observed. Serum high sensitivity C-reactive protein was elevated for up to five years after sepsis resolution (H [6;1685] = 502.2; p < 0.0001).

Discussion: Lipid abnormalities persisted long after the initial septic insult suggesting potential role in accelerating atherosclerosis and other abnormalities. In addition, sepsis seems to blunt statin effectiveness. Additionally, a significant and unexplained drop in statin use was seen in post-septic period.

Conclusions: Our study suggests that persistent derangements of lipid profile components for up to two years after sepsis may be associated with altered risk of atherosclerosis-related events among sepsis survivors.