bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistema IoT para el monitoreo de variables climatológicas en cultivos de agricultura urbana
Authors: Chanchí-Golondrino Gabriel-Elias , Ospina-Alarcón Manuel-Alejandro , Saba Manuel
Published: May 2022

A partir de la creciente tendencia de la agricultura urbana, este trabajo tiene por objetivo la construcción de un sistema IoT para la monitorización y el análisis de variables climatológicas de interés en cultivos de agricultura urbana. La metodología considerada para el desarrollo de la presente investigación está constituida por cuatro fases: selección de herramientas y tecnologías, diseño de arquitectura del sistema IoT, construcción de prototipo del sistema y estudio de caso en el contexto del cultivo de lechuga. Como resultado de la presente investigación, se construyó un sistema IoT basado en herramientas de hardware y software libre, el cual está articulado dentro de la arquitectura convencional de cuatro capas de IoT (captura, almacenamiento, análisis y visualización). Con respecto a las soluciones existentes, la ventaja del sistema es el uso de plataformas portables SBC, así como la inclusión de modelos de aprendizaje automático dentro de la capa de análisis. A partir del estudio de caso, desarrollado sobre un cultivo de lechuga casero, se concluye que las herramientas escogidas permiten realizar de manera adecuada la captura, la monitorización y el análisis de variables climatológicas de interés en cultivos de agricultura urbana. Del mismo modo, se concluye que los modelos de análisis considerados pueden ser personalizados teniendo en cuenta las características agroclimáticas de cada cultivo y que resultan útiles para la toma de decisiones relacionadas con la fisiología de los cultivos.
Diagnosis of Gastrointestinal Parasites in Bovines of the Department of Boyacá, Colombia
Authors: Pulido-Medellin Martin-Orlando , Lopez-Buitrago Henry-Alexander , Bulla-Castañeda Diana-María , García-Corredor Diego-José , Díaz-Anaya Adriana-María , Giraldo-Forero Julio-Cesar , Higuera-Piedrahita Rosa-Isabel
Published: May 2022

Parasitic diseases are considered to be one of the most prevalent pathologies worldwide. They are characterized as one of the most critical sanitary problems in cattle, causing a decrease in the productive capacity of parasitized animals, which translates into economic losses. Intestinal parasitism in cattle is caused by protozoa and helminths, and its manifestation is generally multi-etiological. Clinical signs in gastrointestinal parasitism may vary depending on parasite load, parasite species, and host immunity. This research aimed to determine the prevalence of the main parasitic families affecting cattle in the central province of the department of Boyacá. A cross-sectional study with simple random sampling was carried out, where 716 fecal samples were taken and processed using a modified Ritchie technique. An overall prevalence of 95,6% was determined, and the most prevalent families were Trichostrongylidae, Eimeriidae, Taeniidae, and Trichuridae. The age showed no significant statistical association with most of the parasitic families, except for the Strongyloididae family. The breeds showed a correlation with the Trichostrongylidae, Eimeriidae, Strongylidae, Chabertiidae, and Taeniidae families. The results show the high prevalence of GIP (gastrointestinal parasites) in cattle of the central province of the department of Boyacá.
Cuantificación de residuos asociados a la colecta y uso de sangre en Colombia
Authors: Pardo-Flórez Anderson-Stev , García-Otálora Michel-Andrés , Herrera-Hernández Andrea-Magally , Bermúdez-Forero María-Isabel
Published: May 2022

El objetivo de este estudio fue cuantificar los residuos generados por la operación anual de la Red Nacional de Sangre (RN) de Colombia. Para esto, se calculó la cantidad de residuos generados por las donaciones de sangre y por los hemocomponentes obtenidos, transfundidos e incinerados entre enero y diciembre de 2018, a partir de los informes nacionales de los bancos de sangre y los servicios de transfusión. Los costos de incineración (expresados en dólares estadounidenses) se obtuvieron al multiplicar el total de residuos biológicos por el precio de incinerar un kilogramo en tres zonas distintas de Colombia. Los gases producidos se determinaron empleando los factores de emisión del Ministerio para la Transición Ecológica y el Reto Demográfico de España. La cantidad de residuos no generados se infirió del total de donaciones prevenidas por el Sistema de Información en Hemovigilancia (SIHEVI-INS) implementado en 2018. Como resultado se obtuvo que, en 2018, la RN registró 858 890 donaciones sanguíneas y 334 503 pacientes transfundidos. La aceptación de donantes generó 61,0 megagramos/año de residuos (73.4 % biológicos) con un costo de incineración de $33 418 (±26 087) y emisión de 25,8 megagramos de gases (99,2 % CO2 y 0,6 % NO, NO2 y CO) por incineración. El uso y el descarte de hemocomponentes generaron 349.5 megagramos/año (±99.5), equivalentes a $258 880 (±99 709) y 201.4 megagramos de gases. SIHEVI-INS evitó la producción de 55.1 megagramos/año (±19.1), ahorrando $40 805 (±18 098) y 31.8 megagramos de gases. En conclusión, los 350 megagramos de residuos biológicos producidos por la RN representaron el 0,06-0,08 % del total de residuos o desechos peligrosos generados en Colombia y el 0,75-0,82 % del sector salud.
Aplicación de la computación afectiva en el análisis de la percepción de los asistentes a una feria de emprendimiento del SENA
Authors: Chanchí-Golondrino Gabriel-Elias , Hernández-Londoño Claudia-Estella , Ospina-Alarcón Manuel-Alejandro
Published: May 2022

La computación afectiva es un área de investigación emergente, centrada en el desarrollo de sistemas con capacidad para reconocer, procesar y simular las emociones humanas con el fin de mejorar la interacción entre el usuario y el computador. Uno de los campos potenciales en los que esta puede emplearse es el marketing, a través del estudio de la percepción de los usuarios mediante el uso de técnicas de análisis de sentimientos y emociones sobre las opiniones de los usuarios con respecto a los productos y servicios de las empresas. A manera de contribución, este artículo propone el desarrollo de un estudio de análisis de emociones sobre el texto de las opiniones de los asistentes a una feria virtual de emprendimiento denominada Marketing from Home, la cual fue desarrollada durante el confinamiento de la pandemia y coorganizada por el SENA y la Universidad de Cartagena. Para el desarrollo de esta investigación se tuvieron en cuenta cuatro fases metodológicas: exploración y selección de tecnologías de análisis de emociones; limpieza y adecuación del texto de las opiniones; obtención de la distribución porcentual de las emociones en el texto de las opiniones; y análisis de la percepción de los asistentes a la feria. El estudio permitió determinar la distribución porcentual de las seis emociones básicas (felicidad, enojo, tristeza, euforia, miedo y aburrimiento) sobre el texto de las opiniones de los asistentes a la feria virtual Marketing from Home, de cara a la obtención de la percepción general sobre la logística, los stands virtuales y los productos ofrecidos.
Direkt mitbetroffen: Welche evidenzbasierten Kriterien gibt es für die Gestaltung der ersten Angehörigenberatung von Patient*innen mit akuter Aphasie?
Authors: Thomas M. , Bauch A. , Brummer W. , Hufelschulte L. , Korsukewitz C. , Robrecht D. , Rottgers J. , Grafe M.
Published: May 2022

Zusammenfassung Die vorliegende Arbeit berichtet über die wissenschaftliche Ausarbeitung und klinische Umsetzung von evidenzbasierten Kriterien für die Gestaltung einer ersten Angehörigenberatung von Patient*innen mit akuter Aphasie. Nach einer systematischen Literatur-Recherche und -Analyse erfolgte ein interprofessioneller Austausch zur Erstellung eines Beratungskonzeptes im akutklinischen Setting. Die Evaluation des Vorgehens begann im Oktober 2021 durch eine Fragebogenerhebung mit betroffenen Familienmitgliedern und dauert an. Schlüsselwörter: Akute Aphasie, Angehörige, Beratung Abstract This paper reports on the scientific elaboration and clinical implementation of evidence-based criteria for the design of initial family counseling for patients with acute aphasia. After a systematic literature review and analysis, an interprofessional exchange took place to create a counseling concept in the acute clinical setting. The evaluation of the approach began in October 2021 through a questionnaire survey with affected family members and is ongoing. Keywords: aphasia, acute stage, counseling, family members
Erprobung des MEC-Tests bei kognitiven Kommunikationsstörungen bei leichten kognitiven Beeinträchtigungen und demenziellen Erkrankungen
Authors: Fortmeier K. , Husmann K. , Costa A. S. , Reetz K. , Heim S.
Published: May 2022

Zusammenfassung Zusammenfassung Bei demenziellen Erkrankungen können die sprachlichkommunikativen Fähigkeiten in variabler Art betroffen sein. Trotzdem fehlen im deutschsprachigen Raum geeignete Standardverfahren zur Diagnostik dieser kognitiven Kommunikationsstörungen. Diese Studie beschäftigt sich mit der Erprobung der Anwendbarkeit des MEC-Tests bei dieser Zielgruppe. 16 Patient*innen mit MCI oder leichtgradiger Demenz wurden mit der CERAD Batterie und mit dem MECTest getestet. Bei 94,1% war der MEC-Test durchführbar. Die Durchführungsdauer von durchschnittlich 72,7 Minuten stand nicht im Zusammenhang mit der CERAD. Die Durchführungsdauer unterschied sich zwischen Patienten mit neurodegenerativer vs. affektiver Genese. Jede/r Patient*in zeigte in durchschnittlich 9 Untertests einen Wert unter dem klinischen Trennwert. Die Leistung im MEC stand in Zusammenhang mit der CERAD. Insgesamt wurden sieben der 14 MEC-Untertests aufgrund von Bodeneffekten oder fehlenden Zusammenhängen mit der CERAD als ungeeignet für die Zielgruppe identifiziert. Zusammenfassend ließ sich eine Auswahl an Subtests des MEC-Testverfahren bei dieser Zielgruppe gut anwenden. Schlüsselwörter: Diagnostik, Demenz, Mild Cognitive Impairment (MCI), Logopädie/Sprachtherapie, kognitive Kommunikationsstörung Abstract Dementia is associated with language and communication deficits. However, standardized diagnostic instruments for the assessment of communication disorders for this population are scarce. Therefore, the present study explores whether the Montreal Evaluation of Communication (MEC) test can be applied to persons with dementia or mild cognitive impairment (MCI). Sixteen patients were tested with the (CERAD) and MEC tests. The MEC test could be completely administered in 94.1%. The average duration of 72.7 minutes was not correlated with the Consortium to Establish a Registry for Alzheimer's Disease CERAD score but differed between neurodegenerative vs. affective etiology. Patients showed language/communication deficits in 9 of the MEC sub-tests. Average performance on the MEC test was correlated with the CERAD score. Seven of the 14 MEC subtests were identified as unsuitable for dementia or MCI because of floor effects in performance or poor association with the CERAD. To conclude, the MEC test can be administered to patients with dementia or MCI, particularly a selection of a sub-set of 14 tests. Keywords: diagnostics, dementia, mild cognitive impairment (MCI), speech-language therapy, cognitive communication disorder
PENGELOMPOKAN TWEETS PADA AKUN TWITTER TOKOPEDIA MENGGUNAKAN ALGORITMA DENSITY BASED SPATIAL CLUSTERING OF APPLICATIONS WITH NOISE
Authors: Alamsyah Deanira Qinanty , Sudarno Sudarno , Kartikasari Puspita
Published: May 2022

Social media has become a trend for Indonesian people to express opinions, socialize, and exchange ideas. Internet users in Indonesia in 2021 will reach 202.6 million, 84% of whom use the internet to access social media. Twitter is one of the popular social media in Indonesia. This phenomenon is an opportunity for companies to use Twitter as a marketing tool, one of which is a marketplace company in Indonesia, Tokopedia. This research is intended to cluster tweets uploaded by the @tokopedia Twitter account to find out the type of content that gets a lot of likes and retweets by followers of the @tokopedia Twitter account. Cluster formation is done by applying the Density-Based Spatial Clustering of Applications with Noise algorithm (DBSCAN). DBSCAN is a clustering algorithm based on density. The DBSCAN algorithm requires two parameters, namely the radius (Eps) and the minimum number of objects to form a cluster (MinObj). This research conducted several experiments with different Eps and MinObj parameters on 1.344 tweets that had gone through the stages of removing duplication, text preprocessing, and feature selection. The quality of the cluster formed is measured using the Silhouette Coefficient. Based on the highest average Silhouette Coefficient, the parameter values of Eps=5 and MinObj=3 with Silhouette Coefficient = 0.575 are determined as the best parameters that produce 2 clusters and 7 noise. The type of content that has the highest average number of likes and retweets is the WIB (Indonesian Shopping Time) campaign, so Tokopedia can use this type of content as a marketing tool on Twitter social media because this type of content is preferred by followers of the @tokopedia Twitter account. Keywords: Twitter, Tokopedia, Clustering, DBSCAN, Silhouette Coefficient
Efficient Breach and Ex-post Disgorgement of the Defendant’s Gain: A Comparative Contract Law and Economics Perspective
Authors: Dnes Antony W. , Garoupa Nuno
Published: May 2022

Compensating the plaintiff’s expectancy loss is the established remedy for breach of contract in common-law jurisdictions. Legal theory has examined losses and gains extending beyond lost expectancy, especially gain-based disgorgement as a remedy reflecting the restitution interest in contract law. The theory of efficient breach implies that restitution remedies inaccurately compensate loss, whereas the case in jurisprudence for gain-based disgorgement ignores efficiency all together in focussing on ‘wrongs’ and ‘just’ compensation. We consider legal developments in the UK and US to show (i) efficient breach and gain-based disgorgement can be reasonably reconciled; (ii) a full disgorgement remedy will be evaded because the defendant will deliver specific performance; (iii) careful recognition of the type of externalities affecting the plaintiff, defendant and third parties indicates when disgorgement is useful.
Study of the substrate surface treatment of flexible polypyrrole-silver composite films on EMI shielding effectiveness: theoretical and experimental investigation
Authors: Benzaoui Karim , Ales Achour , Mekki Ahmed , Zaoui Abdelhalim , Bouhemadou Abdelmadjid , Bouaouina Boudjemaa , Benyoubi Fethi
Published: May 2022

Conductive flexible polypyrrole-silver (PPy-Ag) composite films were prepared on Biaxial Oriented Polyethylene Terephthalate (BOPET) substrate with surfaces treated by (3-aminopropyl) trimethoxysilane (APTMS). The surface treatment was carried out to improve the adhesion, morphology, and electrical properties of the deposited film to enhance the Electromagnetic Interference Shielding Effectiveness (EMI-SE). APTMS grafting on the BOPET substrate was confirmed by X-ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) analyses. All structural, morphological, and electrical features of PPy-Ag raised from different AgNO3 molar ratio were investigated. The shielding effectiveness properties, experimentally determined for the synthesized PPy-Ag films were compared to those simulated analytically and numerically based on the transmission line matrix method (TLM). Both analytical and numerical models showed a good agreement with experimental measurements. The obtained results confirmed that the PPy-Ag films of 0.5 M/1 M molar ratio exhibits high EMI shielding performance of about 21 dB along with an electrical conductivity of 47 S/cm. Therefore, the treated surface flexible PPy-Ag films can be considered as potential candidate for high frequency electromagnetic interference shielding applications.
Immobilienmärkte in der historischen Forschung
Authors: Kramper Peter
Published: May 2022

Real estate markets have been all but neglected by historical research. Following a workshop held in Bielefeld in September 2019, this volume seeks to contribute to a better understanding of their characteristics. The introduction starts out with a definition of some key concepts. It then summarizes the state of historical research and argues for a focus on the social and institutional embeddedness of real estate markets. The introduction also gives an outline of the individual papers and a brief summary of some overall findings.
Financial Markets and Land Redistribution in 19th Century East Prussia
Authors: Wandschneider Kirsten
Published: May 2022

How did the emerging market for land in the 19th century influence land distribution in East Prussia? And how did land markets respond to the emergence of financial institutions that relied on land as collateral but also affected the ease and speed of land transfer?

Focusing on the example of a specific financial institution – the East Prussian Landschaft – this paper empirically tests the hypothesis that the Landschaft credit institutes, through their provision of privileged credit, enabled noble estates to expand their landholdings. It also tests whether the existence of Landschaft-credit helped noble estates to remain in the hands of nobles and halted estate sales to the emerging bourgeoisie. The analysis combines several datasets on East Prussian landed estates in 1796, 1834 and 1882 and matches these with borrowing records of the East Prussian Landschaft from 1823 and 1829. The study finds that access to Landschaft-credit correlates positively with estate size over the 19th century, suggesting that the Landschaft credit institutes did play a role in ownership concentration. The results regarding the transfer of estates from the nobility to the bourgeoisie show a weaker link between Landschaft-credit and ownership status of estate holders.
Mass Weddings, Baby Boom and Full Employment?
Authors: Somcutean Cristina
Published: May 2022

In 1933, the German government introduced the marriage loan for newlyweds, a policy aimed at increasing marriages and births as well as male employment, which entailed a work ban for the wife and sizeable credit deductions for children. This paper illustrates that the policy was rather ineffective based on a critical evaluation of the existing literature on the topic, how the policy was implemented in practice, as well as a correlation and interrupted time series analysis and consideration of the historical context of the period between 1925 and 1939. This result starkly contrasts to the substantial changes expected at the time of the introduction. In theory, only a small fraction of newlyweds was eligible for the loan. In practice, the development of marriages postintroduction significantly differed from the period prior to the policy, but causation is unclear. While births increased, this can be attributed to a combination of policies and the improved economic environment compared to the crisis years. The sharp decrease in unemployment probably resulted from the introduction of several targeted policies and embellishment of unemployment statistics.
Fabrication of bio-based composite fillers based on the combination of crystallization and gelation
Authors: Nie Jingyi , Liu Xinming , Liang Jiantao , Zhang Meiyun , Han Wenjia
Published: May 2022

Fillers are the second major component of paper, and can give certain properties to paper-based materials. However, if we want to use fillers to develop novel functional paper-based materials, some challenges have to be considered such as filler functionality, retention rate, and the negative effects. To meet with these challenges, the present work proposed a fabrication concept of bio-based composite fillers. The concept combined the crystallization of target component and the gelation process of chitosan (CS), simultaneously. The gels carried and protected the crystals, and served as bridge between crystal of fillers and the paper matrix. To explore and demonstrate the concept, CaCO3/CS bio-based composites were successfully fabricated. The composite fillers were further optimized to be suitable for paper-making. The fabrication concept could significantly increase the filler retention rate (up to 90.57 %), the filler bondability (increased over 10 times) and the mechanical strength (59.7 % higher than paper without fillers). The fabrication concept was also applicable to functional materials. Zeolitic imidazolate framework-8 (ZIF-8)/CS composite fillers were successfully fabricated, and endowed the resulted paper with high surface area (180 times higher than pure cellulose paper). This fabrication concept would be useful to develop functional paper-based materials in the future.
INTEGRATING COMPREHENSIVE INDUSTRIAL RAW MATERIAL DELIVERY PLANNING AND PRODUCT-SERVICE SYSTEM INVENTORY CONTROL
Authors: Hamzah Norhamiza , Ismail Siti Zubaidah
Published: May 2022

Product Service Systems (PSS) are integrated product and service offerings that provide superior customer value in industrial applications for planning, inventory control, delivery planning and a use jointly defined. Delivery planning is a particular challenge in providing personal security services. A good delivery planning is can minimize problem from great complexity subject to various constraints within a large solution space. Organizations offering PSS services or industrial services suffer from decision support to put in place robust capacity planning strategies in highly dynamic and uncertain environments. This paper presents a simulation-based approach to capacity planning. The goal of this project to identify potential routes of integration between two factors deliveries planning and PSS inventory control that could improve the delivery performance based on the raw material industry. Emphasis is placed on capacity planning for PSS inventory control and delivery planning. By using IDEFØ (Integration Definition for Function) generic modelling and Delmia Quest simulation software in this research able to achieve the time required. The advantage of IDEFØ includes: a well-tested language and a comprehensive systems modelling technique. The resulting IDEFØ models are well-defined, easy to understand, well-structured, easy to change and use, and can be extended to any depth of detail. Meanwhile, Delmia Quest software will provide real time simulation for production process and generated report for actual operational situation. After a few general considerations on robust capacity planning for the control and delivery of technical support inventory using scenario simulations, the main elements of the agent-based simulation method are presented. The most important parameters given by company A, the control parameters and the performance indicators are discussed and the scenario planning process based on the simulation is described.
Risk Management: Identification and Mitigation in Maintenance Project During COVID-19 Outbreak (A Case Study in Telco Maintenance Project)
Authors: Tripiawan W. , Frestikawati W.F.
Published: May 2022

The continuity and smooth running of the telecommunications system plays an important role during this pandemic. The smooth running of the telecommunications system cannot be separated from the maintenance function of the equipment used to support the telecommunications system. PT. HIJ is one of the partners of the company PT. Telekomunikasi Indonesia, which is engaged in the maintenance of telecommunications equipment. One of the projects handled by PT. HIJ is a telecommunications equipment maintenance project in the East Java area network. As is known, in a telecommunications equipment maintenance project there are several risks that have an impact on the completion of the project. The results of the identified risk assessment will be developed further into risk mitigation, i.e. actions that can reduce the identified risk. As a result of the research, five risk aspects were identified: maintenance, finance and accounting, human resources (HR), procurement, and operational. According to the risk assessment result, there are 19 risks that can be classified based on risk level, with 7 in the moderate level of risk, 5 in the high level of risk, and 7 in the extreme level of risk. As a result of the research, it is suggested that risk mitigation be implemented for 5 risks with a high level of risk and 7 risks with an extreme level of risk.
Design of Feed Product Distribution System using Vehicle Routing Problem (VRP) and Simulated Annealing (SA) Methods at XYZ, L.P
Authors: Sriwana I.K. , Syauqillah N. , Erni N. , Rasjidin R. , Rachman Taufiqur
Published: May 2022

A good distribution system can give an impact on cost efficiency and delivery time. XYZ , L.P is an animal feed firm who faces problems of high cost and long time to carry out distribution activities. This happens after an increase in demand for animal feed which was not followed by significance of increase in cost and distribution time. The research aimed to design a distribution system and determine an optimum distribution route using efficient resources, in order to obtain a minimum vehicle mileage. The research consists of 8 stages. Vehicle Routing Problem (VRP) with Nearest Neighbor method was carried out, followed by optimizing the route solution obtained from the VRP calculation using the Simulated Annealing (SA) Algorithm. According to the route optimization using SA, the mileage, travel time, and distribution costs can be reduced by 40.04%, 75%, and 49.85%, respectively. It is, therefore, assumed that the firm can gain benefits, in terms of cost and time, by implementing the proposed distribution method.
State of the Art of Dynamic Value Stream Mapping in the Manufacturing Industry
Authors: Thulasi M. , Faieza A.A. , Azfanizam A.S. , Leman Z.
Published: May 2022

Value stream mapping (VSM) is considered as an important tool in lean manufacturing that allows analysts to visualize the actual situation that happens in the production value stream. However, in high-variety and low-volume factories, conventional VSM which is more static in nature, unable to give real vision of the variability problems concerning production process. As such, the purpose of this paper is to review the role of VSM in a dynamic context which is more efficient in today`s complex and dynamic manufacturing system.This paper discusses the conventional VSM, its applications and limitations as well as how conventional VSM integrates with computer simulation to display more dynamic behavior. Both these conventional and dynamic VSM have their own benefits and drawbacks according to their applications in the manufacturing industry. As a conclusion, this paper shows that simulation applications can help to support VSM for companies that intend to transform to lean. This work is very useful for both scholars and  companies to know how much an output can be produced within the predicted lead time before making physical changes to the system in order to save both money and time.
Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemia
Authors: Chan Melody Lok-Yi , Shiu Sammy Wing-Ming , Cheung Ching-Lung , Yu-Hung Leung Anskar , Tan Kathryn Choon-Beng
Published: May 2022

The inducible degrader of low-density lipoprotein receptor (IDOL) is an E3 ubiquitin ligase involved in the post-transcriptional regulation of LDL receptor (LDLR). Statins lower plasma LDL by activating transcription of hepatic LDLR expression, and we have determined whether statins modulate IDOL expression and influence LDLR protein abundance. IDOL expression in monocytes and serum IDOL level was determined in statin-treated familial hypercholesterolemia (FH) patients and compared with control subjects. Serum IDOL level was also evaluated in a group of untreated FH patients before and after the initiation of statin. The mechanism underlying the inhibitory effect of statin on IDOL expression was investigated in vitro. In statin-treated FH patients, serum IDOL level and its expression in monocytes was reduced compared with control (P < 0.05). In contrast, untreated FH patients had higher serum levels of IDOL and proprotein convertase subtilisin/kexintype 9 (PCSK9) than control (P < 0.05), and serum IDOL level decreased after statin therapy (P < 0.05) whereas an increase was observed in PCSK9 level (P < 0.01). In vitro, atorvastatin significantly decreased IDOL abundance in a dose-dependent manner in cultured macrophages and hepatocytes with a concomitant increase in LDLR expression. The transcription of IDOL was restored by adding either an LXR agonist T0901317 or oxysterol 22(R)-hydroxycholesterol, indicating that statin inhibited IDOL expression by reducing LXR activation. The LXR-IDOL-LDLR axis can be modulated by statins in vitro and in vivo. Statins inhibit IDOL expression by reducing LXR activation and upregulate LDLR, and statins exert the opposite effect on IDOL and PCSK9.
Prognostic value of dysnatremia for survival in neuroendocrine neoplasm patients
Authors: Refardt Julie , Brabander Tessa , Minczeles Noémie S , Feelders Richard A , de Herder Wouter W , Hofland Johannes
Published: May 2022

Objective

Hyponatremia and hypernatremia are common electrolyte abnormalities in patients with malignancy and have been independently associated with worse survival outcomes. To date, there are no data on the impact of dysnatremia on survival outcomes in patients with neuroendocrine neoplasms (NENs).

Design

This study involves retrospective cohort analysis from a tertiary care center of NEN patients treated with peptide receptor radionuclide therapy (PRRT) with a cumulative activity of at least 3.7 GBq 177Lu-DOTATATE between the years 2000 and 2015.

Methods

Comparison of overall survival of patients with the occurrence of hyponatremia (serum sodium < 135 mmol/L) or hypernatremia (serum sodium > 145 mmol/L) before starting or during PRRT was perfomed.

Results

A total of 649 patients were included. Hyponatremia occurred in 57 patients during the observation period and was associated with a shorter median overall survival (95% CI) of 25 months (14–36) compared to 55 months (48–61) of the 512 normonatremic patients (P < 0.001), adjusted hazard ratio (HR): 1.48 (95% CI: 1.04–2.12). Overall survival time was reduced regardless of whether hyponatremia was present at baseline or during PRRT. In contrast, hypernatremia occurred in 80 patients and was associated with a longer median overall survival (95% CI) of 94 months (47–140) compared with the 512 normonatremic patients (P = 0.018), adjusted HR: 0.61 (95% CI: 0.40–0.92). This association was driven by the patients with hypernatremia during PRRT. No association between dysnatremia and progression-free survival after PRRT was observed.

Conclusions

The occurrence of hypo- or hypernatremia in PRRT-treated NET patients is associated with opposing outcomes with regard to overall survival. Sodium levels might have a prognostic role in these patients.
Liraglutide stimulates the β-catenin signaling cascade in mouse epididymal fat tissue
Authors: Gu Jianqiu , Shao Weijuan , Liu Dinghui , Feng Jia Nuo , Pang Juan , Jin Tianru
Published: May 2022

Although canonical Wnt signaling pathway activation was shown to negatively regulate adipogenesis, recent investigations suggest that Wnt pathway effectors TCF7L2 and β-catenin (β-cat) in adipose tissues are also involved in energy homeostasis during adulthood. In assessing the metabolic beneficial effect of GLP-1-based diabetes drugs in high-fat diet (HFD)-challenged mice, we observed that liraglutide treatment affected the expression of a battery of adipose tissue-specific genes, including those that encode adiponectin and leptin, mainly in epididymal white adipose tissue (eWAT). Fourteen-week HFD challenge repressed TCF7L2 and β-cat S675 phosphorylation in eWAT, while such repression was reversed by liraglutide treatment (150 µg/kg body weight daily) during weeks 10–14. In Glp1r−/−mice, liraglutide failed in stimulating TCF7L2 or β-cat in eWAT. We detected Glp1r expression in mouse eWAT and its level is enriched in its stromal vascular fraction (SVF). Mouse eWAT-SVF showed reduced expression of Tcf7l2 and its Tcf7l2 level could not be stimulated by liraglutide treatment; while following adipogenic differentiation, rat eWAT-SVF showed elevated Tcf7l2 expression. Direct in vitro liraglutide treatment in eWAT-SVF stimulated CREB S133, β-cat S675 phosphorylation, and cellular cAMP level. Thus, cAMP/β-cat signaling cascade can be stimulated by liraglutide in eWAT via GLP-1R expressed in eWAT-SVF.
Distributed machine learning for IoT
Authors: Kadzhaia Volodymyr , Raudys Aistis , Raudys Aistis
Published: May 2022

In the modern world, big data is used in machine learning, which is quite difficult to process on a single computer, so various methods for parallel processing of such data are being developed. But what about microcontrollers? In a cloud system, microcontrollers are often found, thanks to which they make pacification of various devices, and sometimes you have to work with big data. In microcontrollers, the memory is quite small and the processor is not as productive as on modern supercomputers. Therefore, many scientists propose various methods for parallel processing of big data for embedded systems, one of such methods is proposed by the author of this article.
3D paviršiaus formavimo 2D vaizdų pagrindu algoritmų tyrimas
Authors: Nakrošis Arnas , Kriščiūnas Andrius
Published: May 2022

Tobulėjant technologijoms pramonės ir viešajame sektoriuose informacijos atvaizdavimui vis dažniau yra naudojami trimačiai vaizdai, leidžiantys darbuotojams lengviau suprasti gautus rezultatus ar surinktą informaciją. Nors šiuo metu jau egzistuoja algoritmai leidžiantys standartinėmis priemonėmis surinktų 2D vaizdų pagrindu formuoti trimačius vaizdus, tačiau tokių algoritmų pateikiamų rezultatų kokybę dar vis smarkiai atsilieka nuo rinkos poreikio. Šio tyrimo metu buvo atliekama esamų algoritmų analizė siekiant pasiūlyti sprendimą, kuris leistų pasiekti geresnius rezultatus lyginant su literatūroje nagrinėjamais atvejais. Rezultate autorių pasiūlyta algoritmu kombinacija leidžia suformuoti 3D paviršiu remiantis santykinai nedideliu 2D vaizdų kiekiu.
Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis
Authors: Naung Tun Han , Kyaw May Thu , Rafflenbeul Erik , López Suástegui Xiuhtlaulli
Published: May 2022

Venous thromboembolism (VTE) is one of the leading causes of post-operative morbidity and mortality. Over previous decades, heparin and warfarin were the predominant therapeutic options for post-operative thromboprophylaxis. However, their use is limited by drawbacks including a narrow therapeutic range, numerous food and drug interactions, and the need for regular monitoring for dose adjustments. Recently, direct oral anticoagulants (DOACs), such as dabigatran etexilate (a direct thrombin inhibitor) and apixaban, rivaroxaban and edoxaban (direct factor Xa inhibitors), have been developed to overcome these issues. DOACs have shown promising results in Phase III clinical trials for post-operative VTE prophylaxis. This review summarises the pharmacological profile of DOACs and highlights the use of DOACs in post-operative VTE prophylaxis based on the available clinical trial data.
USES AND GRATIFICATIONS THEORY IN E-COMMERCE: HABIT AND SOCIAL PRESENCE
Authors:   St. Antony’s College, University of Oxford, UK, Krasonikolakis Ioannis
Published: May 2022

Digital media have transformed the customer buying journey and recent studies show that different media (devices) are used for different steps of the decision-making process. In this study, we apply the Uses and Gratifications (U&G) theory in the marketing context in order to investigate consumers’ choice to use desktop or mobile devices for conducting purchases. Habit and social presence are tested as moderators of the relationship between intention to buy and purchase via the two media. We report results from two laboratory experiments involving an actual purchase in various product categories. Findings indicate that consumers use desktop to make significantly more purchases than via mobile phone. Further, the positive relationship between the intention to buy and product purchase is moderated by the habitual use of the medium. Purchase intention x habitual use of the medium interactions are related to purchase behavior when habit is strong. Similarly, the presence of other people while the purchase is being made via desktop and mobile devices increases the likelihood of product purchase. Several implications for further academic research and managers are discussed.
VALUE CO-CREATION THROUGH TECHNICAL INTERN TRAINEES IN JAPANESE HEALTHCARE
Authors:   Kwansei Gakuin University, Japan, Katsuda Atsushi , Naito Yoshiyuki ,   Aijinkai Healthcare Corporation, Japan
Published: May 2022

A long-term care insurance system in Japan was established in 2000 to specifically care for the elderly, but due to the declining birthrate, the working population is decreasing and there is a shortage of long-term care workers. In 2016, the Japanese government established the Asia Health and Wellbeing Initiative (AHWIN) to address this shortage of long-term care workers, aiming to build a sustainable healthcare system throughout the Asian region. In one such measure people from Viet Nam can learn Japanese-style long-term care skills as technical interns in Japan. The APS (Aijinkai, Pegasus, Seichokai) Consortium comprising three healthcare business groups based in Japan, has been actively implementing AHWIN initiatives. A case study of one such initiative examined based on the concept of value, and the co-creation of value between technical interns from Viet Nam and the Japanese healthcare system, with explanation of the long-term care environment. First, we summarize the origins of the healthcare system in Japan and clarify that the issue from the perspective of value. Next, we examine the shift to value creation through value co-creation between service providers and users, rather than unilateral process-oriented value creation, by utilizing the healthcare ecosystem based on the service ecosystem in servicedominant logic. The mega-level and macro-level value co-creation in the healthcare ecosystem was also found to affect the meso-level and micro-level value co-creation.
A Meta-Analysis of the Impact of Working Capital on Profitability
Authors:   The IIE Vega School, South Africa, Enow Samuel Tabot
Published: May 2022

Working capital and profitability are two important core concepts in financial management and accounting. The management of these two concepts can affect an investor’s decision to invest in a firm. Thus, there have been many publications stressing the need to effectively manage working capital because of its significant impact on profitability. However, working capital has been hardly mentioned by any senior manager or executive as one of the value drivers that enhances profitability. Therefore, the aim of this study is to investigate the strength and the extent to which profitability depends on working capital. This study is motivated by a lack of research in this area. Using a meta-analysis of 32 published journal articles and dissertations, the study finds that working capital accounts for 37.8% of the variability in profitability. Also, the results of a Kolmogorov-Smirnov test reveal that the distribution of the coefficient of determination is not normally distributed and is not a good fit to explain the effect of working capital on profitability, hence independent of each other. The implication of this study is that research entitled “the effect of working capital management on profitability” should be scrutinized before being accepted for publication.
Mammals of the Cape of Good Hope Nature Reserve, Western Cape, South Africa
Authors: Fraser Mike
Published: May 2022

The status of all the mammal species that have been recorded in the Cape of Good Hope Nature Reserve (the southern section of the Ta-ble Mountain National Park) is described. A total of 76 species has been recorded, of which 56 occur or have occurred naturally, and 13 are now extinct. More than 20 species have been deliberately or acci-dentally introduced. The history and management of large, non-native herbivores released into the Reserve for public spectacle is described in the context of changing attitudes towards conservation priorities and visitor perceptions.
Characterization of plane to plane map germs by invariants
Authors: ASLAM Saima , BİNYAMİN Muhammad Ahsan
Published: May 2022

We characterize the map germs of corank at most 11 with AA-codimension ≤6≤6 in terms of certain invariants such as multiplicity and the number of cusps of map germs. On the basis of this characterization we present an algorithm to classify the map germs of corank at most 11 from (C2,0)(C2,0) to (C2,0)(C2,0) with AA-codimension ≤6≤6 and also give its implementation in the computer algebra system SINGULAR.
Classification mechanisms for digitalized information in web application development, taking into account cloud server deployment trends
Authors: Tyturenko Zh. , Zinchenko I. , Olshevska O. , Volkova A.
Published: May 2022

With the transition from natural to virtual communication, there are new technologies for presenting information, the perception of which depends on its presentation by modern multimedia. Visual perception plays an important role in everyday life, helping in learning and communicating with other people. Behind the most effective perception is a complex process of understanding the information obtained. Visual perception of information includes the processes of seeing and reading. Building assumptions on what we see, we rely on expectations, beliefs, past knowledge and previous experience. Reading is a complex activity that involves both the process of perception and thought. At the very beginning of the formation of reading, understanding is not common, but only after perception, as the development and automation of reading skills, understanding begins to outpace the process of perception, manifested in the emergence of semantic assumptions, guessing meaning within words. Perception of visual image is accompanied by the actualization of its auditory-motor image, without which it is impossible to recognize. Reading is accompanied by inner speech. The same information can be understood by different people with different degrees of depth, which entails the existence of factors that affect the process of perception and understanding of texts. Such factors can be divided into the following groups: characteristics of the individual who acts as a subject of perception and understanding; parameters of the text and the reality that is reflected in this text; features of the situation in which the process of perception and understanding takes place. Text in a virtual environment, ie media information - is more accurately and quickly perceived by a person and it depends on various factors influencing perception, as well as the type and method of presenting information.
The purpose of the study is to analyze the perception of digitalized information, the formation of recommendations for professionals with UI / UX, which will be further formed into a prototype of a possible web directory. The aim is also to develop a possible tool model that can be used not only by the above specialists, but also by SMM-managers, business analysts and others. The methods of research were chosen analysis - the study of individual parts of the objects of study, comparing different approaches or their individual components to obtain a holistic picture of the subject area.
Засіб автоматизації заходів з знежкодження вибухових пристроїв
Authors: Сандлер А. К. , Опришко М. О.
Published: May 2022

Досвід застосування технічних засобів розмінування визначив, що існує певна невідповідність характеристик відомих типів засобів характеру та обсягам задач, які фактично вирішуються. Необхідність створення новітніх зразків технічного обладнання, в умовах часових та економічних обмежень, змушують здійснювати корегування військово-технічної політики, виходячи з врахування, насамперед, матеріальних передумов. В умовах випереджальної тенденції розвитку мінної зброї, спроби досягти паритету в розвитку засобів протидії мінної загрози неминуче ведуть до відставання. Альтернативою, у ситуації, що склалася, є принцип асиметричного розвитку комплексу знешкодження вибухових пристроїв, який полягає у застосуванні широкого спектру технічних засобів та об'єднанні їх у раціональному співвідношенні у єдину систему. В той же час, відсутня єдина методологія структурно-параметричного синтезу комплексу розмінування, складові частини якої були б адаптовані то протидії сучасних загрозам та викликам, що й обумовлює одну із ключових науково-прикладних проблем.
Поставлена задача вирішується тим, ріжучий вузол для різання дротів при проведенні заходів з розмінування вибухових пристроїв, що складається з корпусу з задньою кришкою до  якого прикріплено скобу з нерухомим ножом, який взаємодіє з рухомим ножом, закріпленою на рухомому штоці з поршнем та ущільненнями, який разом зі зворотною пружиною, розташовано у корпусі, набоїв, продукти згоряння піротехнічних сумішів яких приводять до дії шток з рухомим ножом, штоку разом з затворною рамою, пружиною і затвором з ударником, ударно-спускового механізму у складі спускового гачка, курка, пружини та шептала автоспуску, засувки сповільнювача курка запобіжника та який відрізняється тим, що набої замкненого типу містяться у барабані з зубцями храпового колеса, що взаємодіють з собачкою затворної рами, а сам ріжучий вузол сполучається основою пристрою вузла різання за допомогою опорно-захисних пластин.
Розробка WEB-додатку для лабораторії COVID-19
Authors: Котлик С. В. , Романюк О. Н. , Соколова О. П. , Клюшніков М. М.
Published: May 2022

Під час пандемії COVID-19 цифрова охорона здоров'я є ключовим чинником боротьби з поширенням вірусу. Одним з наслідків поточної пандемії вже зараз можна назвати прискорене впровадження цифрових технологій у різних областях. Саме завдяки цьому більшість розробників по всьому світу, під час поширення вірусу COVID-19, вирішили здійснити ідею створення програмних додатків, які б допомогли людству в такій напруженій боротьбі з невідомою тяжкою хворобою. Багато зусиль докладають і вітчизняні вчені, розробляючи різні пристрої та програми, які можуть допомогти у цьому протистоянні.
На кафедрі ІТіКБ ОНТУ спільно з кафедрою ПЗ ВНТУ вирішили за допомогою комп'ютера автоматизувати роботу з інфікованими COVID-19, полегшивши працю медиків, змушених щодня зустрічатися з величезною кількістю тих, хто потребує допомоги.
Створений додаток "Проти-Covid 19" доступний у мережі Internet по доменному імені та призначений для використання лікарями та лаборантами лабораторій COVID-19 та інфекційних лікарень, які мають доступ до інтернету на мобільному телефоні або стаціонарному комп'ютері. Для реалізації клієнтської частини WEB-програми були використані HTML5, CSS3, jQuery, Bootstrap 3, Flex-box. Серверна частина побудована за допомогою локального сервера Apache 2.4, мови програмування PHP 8.0, PHP-фреймворку Yii2 та бази даних MariaDB 10.5.
Додаток "Проти-Covid 19", що є частиною проекту Телемедицина, забезпечує виконання наступних функцій: створювати нові записи з даними вхідних матеріалів дослідження; створювати записи про результати дослідження; створювати протоколи досліджень із можливістю пов'язувати з ними результати досліджень; додавати нові медичні установи, тест-набори, контролі, спеціальності та спеціалістів до бази даних за потребою; редагувати та видаляти записи, результати та протоколи з бази даних; шукати необхідну інформацію за допомогою пошукових полів; генерувати PDF-документи з бланком результатів дослідження, даними протоколу чи звіту за вибраний період та можливістю друку цих документів.