bluuebunny/crossref_metadata_2025 huggingface dataset:
Financial self-sufficiency of Ukrainian territorial communities and local economic development: Modeling the causal relationship
Authors: Voznyak Halyna , Kaplenko Halyna , Koval Vasyl , Druhova Vira , Mulska Olha
Published: July 2023

The financial self-sufficiency of communities determines their ability to create additional jobs, attract investment resources, offer quality social services, and improve the population’s living standards and well-being. The study aims to identify the casual relationships between financial self-sufficiency and local economic development of Ukrainian territorial communities during economic instability. The paper used integrated assessment based on a spatial approach (identifying the level of local economic development), indicative method (calculating empirical values of financial self-sufficiency of communities), VEC model (analyzing the sensitivity of local economic development to changes in financial self-sufficiency), balanced multi-component regression method (modeling the relationship between local economic development and financial self-sufficiency). Data were gathered on all territorial communities of Ukraine in 2021. The results show that the highest level of local economic development was observed in Dnipropetrovsk oblast (empirical coefficient equal to 0.855), high levels in Kharkiv, Zaporizhzhia, Odesa, Kyiv, and Poltava oblasts (0.787; 0.687; 0.684; 0.663 each, respectively), and moderate levels in Zakarpattia (0.448) and Kirovohrad (0.433) oblasts. With increased financial self-sufficiency, local economic development can exceed 2%; a 1% increase in the decentralization of tax revenues and expenditures simultaneously leads to an increase in the attractiveness of the investment climate as an indicator of local economic development (2.3-6.6%). The study proves that the territorial communities of the regions characterized by a low level of local economic development demonstrated higher values of decentralization of interbudgetary revenues than those with higher values of local economic development.
Machine learning approach for the estimation of missing precipitation data: a case study of South Korea
Authors: Han Heechan , Kim Boran , Kim Kyunghun , Kim Donghyun , Kim Hung Soo
Published: July 2023

Precipitation is one of the driving forces in water cycles, and it is vital for understanding the water cycle, such as surface runoff, soil moisture, and evapotranspiration. However, missing precipitation data at the observatory becomes an obstacle to improving the accuracy and efficiency of hydrological analysis. To address this issue, we developed a machine learning algorithm-based precipitation data recovery tool to detect and predict missing precipitation data at observatories. This study investigated 30 weather stations in South Korea, evaluating the applicability of machine learning algorithms (artificial neural network and random forest) for precipitation data recovery using environmental variables, such as air pressure, temperature, humidity, and wind speed. The proposed model showed a high performance in detecting the missing precipitation occurrence with an accuracy of 80%. In addition, the prediction results from the models showed predictive ability with a correlation coefficient ranging from 0.5 to 0.7 and R2 values of 0.53. Although both algorithms performed similarly in estimating precipitation, ANN performed slightly better. Based on the results of this study, we expect that the machine learning algorithms can contribute to improving hydrological modeling performance by recovering missing precipitation data at observation stations.
Bacterial Pathogens: Potential Source For Antimicrobial Peptides
Authors: AlMatar Manaf , Albarri Osman , lakhal Raja , Ocal Melda Meral , Var Işıl , Köksal Fatih
Published: July 2023

As more antibiotics become ineffective due to drug-resistant bacteria, alternative therapies
for infections must be prioritized. While pathogenic bacteria are a major threat, they also supply
a massive reservoir of potential drugs for treating a wide range of illnesses. The concerning
emergence of antimicrobial resistance and the rapidly dwindling therapeutic pipeline need the
quick discovery and development of new antibiotics. Despite their great promise for natural product
medicine development, pathogenic microorganisms have remained mostly unexplored and understudied.
We review the antibacterial activity of specialized metabolites derived from pathogenic
bacteria, emphasizing those presently in pre-clinical studies or with promise for medication development.
Several atypical biosynthetic pathways are outlined, together with the crucial functions.
We also discuss the mechanism of action and antibacterial activities of the antibiotics under consideration.
Pathogenic bacteria as a rich source of antibiotics, along with recent advances in genomics
and natural product research methods, may usher in a new golden age of antibiotic discovery.
Current Market Potential and Prospects of Copper-based Pyridine
Derivatives: A Review
Authors: Tyagi Shivani , Mishra Rakhi , Mazumder Rupa , Mazumder Avijit
Published: July 2023

Nicotine, minodronic acid, nicotinamide (niacin), zolpidem, zolimidine, and
other pyridine-based chemicals play vital roles in medicine and biology. Pyridinecontaining
drugs are widely available on the market to treat a wide range of human
ailments. As a result of these advances, pyridine research is continually expanding, and
there are now higher expectations for how it may aid in the treatment of numerous
ailments. This evaluation incorporates data acquired from sources, like PubMed, to
provide a thorough summary of the approved drugs and bioactivity data for compounds
containing pyridine. Most of the reactions discussed in this article will provide readers
with a deeper understanding of various pyridine-related examples, which is necessary
for the creation of copper catalysis-based synthetic processes that are more accessible,
secure, environmentally friendly, and practical, and that also have higher accuracy and
selectivity. This paper also discusses significant innovations in the multi-component
copper-catalyzed synthesis of N-heterocycles (pyridine), with the aim of developing
precise, cost-effective, and environmentally friendly oxygenation and oxidation synthetic
methods for the future synthesis of additional novel pyridine base analogs. Therefore,
the review article will serve as a novel platform for researchers investigating copperbased
pyridine compounds.
Effect of Transcranial Pulse Stimulation for the Treatment of Alzheimer´s
Disease and its Related Symptoms
Authors: Fernández-Castaño Ramiro , Fernández-Blázquez Miguel Ángel , Echevarría Fernández Iria , Cabrera-Freitag Manuela , Freitag Karin
Published: July 2023

Alzheimer's disease (AD) is the most common cause of neurodegenerative cognitive impairment. Brain stimulation techniques based on the delivery of transcranial shockwaves are currently being studied for their increasing popularity as an approach to modulate the human brain in a focal and targeted manner making this therapy a promising line of action against AD. In the present manuscript, we review for further understanding whether transcranial pulse stimulation (TPS) is a beneficial treatment for AD patients. PubMed, Google Scholar, and Cochrane databases were accessed with the search criteria set from year 2001 to 2022 and the following keywords were used: “transcranial pulse stimulation”, “focused ultrasound”, “noninvasive treatment and Alzheimer” and “TPS”. The search was focused on papers that provide evidence on the biological bases of the method, as well as its safety and tolerability. Even though more studies are needed with greater scientific rigor, such as a double-blind and randomized study versus a placebo, TPS is an excellent and safe therapeutic option for AD. This novel approach accompanies currently available treatments and complements them, helping to maintain greater stability of the disease and slowing its progression. The biological effects and potential mechanisms of action of TPS for the improvement of cognitive function are further discussed.
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on
DNA Methyltransferases: Potential in Epigenetic Cancer Therapy
Authors: Kumar Vipul , Dhanjal Jaspreet Kaur , Sari Anissa Nofita , Khurana Mallika , Kaul Sunil C. , Wadhwa Renu , Sundar Durai
Published: July 2023

Background:

DNA methyltransferases (DNMTs) have been reported to be potential
drug targets in various cancers. The major hurdle in inhibiting DNMTs is the lack of knowledge
about different DNMTs and their role in the hypermethylation of gene promoters in cancer cells.
Lack of information on specificity, stability, and higher toxicity of previously reported DNMT inhibitors
is the major reason for inadequate epigenetic cancer therapy. DNMT1 and DNMT3A are
the two DNMTs that are majorly overexpressed in cancers.

Objective:

In this study, we have presented computational and experimental analyses of the potential
of some natural compounds, withaferin A (Wi-A), withanone (Wi-N), and caffeic acid
phenethyl ester (CAPE), as DNMT inhibitors, in comparison to sinefungin (SFG), a known dual inhibitor
of DNMT1 and DNMT3A.

Methods:

We used classical simulation methods, such as molecular docking and molecular dynamics
simulations, to investigate the binding potential and properties of the test compounds with
DNMT1 and DNMT3A. Cell culture-based assays were used to investigate the inactivation of
DNMTs and the resulting hypomethylation of the p16INK4A promoter, a key tumour suppressor that
is inactivated by hypermethylation in cancer cells, resulting in upregulation of its expression.

Results:

Among the three test compounds (Wi-A, Wi-N, and CAPE), Wi-A showed the highest
binding affinity to both DNMT1 and DNMT3A; CAPE showed the highest affinity to DNMT3A,
and Wi-N showed a moderate affinity interaction with both. The binding energies of Wi-A and
CAPE were further compared with SFG. Expression analysis of DNMTs showed no difference between
control and treated cells. Cell viability and p16INK4A expression analysis showed a dose-dependent
decrease in viability, an increase in p16INK4A, and a stronger effect of Wi-A compared to
Wi-N and CAPE.

Conclusion:

The study demonstrated the differential binding ability of Wi-A, Wi-N, and CAPE to
DNMT1 and DNMT3A, which was associated with their inactivation, leading to hypomethylation
and desilencing of the p16INK4A tumour suppressor in cancer cells. The test compounds, particularly
Wi-A, have the potential for cancer therapy.
Antimicrobial Activity of Halogen- and Chalcogen-Functionalized Thiazoloquinazolines
Authors: Kut Diana , Kut Mykola , Komarovska-Porokhnyavets Olena , Kurka Maria , Onysko Mykhaylo , Lubenets Vira
Published: July 2023

:

The investigation is devoted to the assessment of the potential antimicrobial use of new chalcogen-
functionalized thiazolo[2,3-b]quinazolin-5-ones, halides and trihalides of thiazolo[3,2-
a]quinazolin-10-ium and tribromides thiazino[3,2-a]quinazolin-11-ium. The compounds under study were
obtained by electrophilic intramolecular heterocyclization. A high bactericidal and fungicidal effect
against some gram-positive and gram-negative bacteria and fungi has been revealed for the investigated
compounds. The "structure-activity" relationship has been established; the influence of the chalcogen's
nature and the type of substituents in the thiazoline and pyrimidine cycles on the biological activity of the
investigated thiazolo- and thiazinoquinazolines is shown. Angular 4-methyl-5-oxo-1-
((trihalogenotellanyl)methylidene)-8-(trifluoromethyl)-1,2,4,5-tetrahydrothiazolo[3,2-a]quinazolin-10-
ium halides have been found to show the highest bactericidal activity to the gram-negative culture of
Escherichia coli.
Multiple Sclerosis Risk Among Anti-tumor Necrosis Factor Alpha Users:
A Methodological Review of Observational Studies Based on Real-world
Data
Authors: Li Lingyi , Etminan Mahyar , Kaplan Gilaad G. , Tremlett Helen , Xie Hui , Aviña-Zubieta J. Antonio
Published: July 2023

Epidemiologic studies on the risk of multiple sclerosis (MS) or demyelinating events associated
with anti-tumor necrosis factor alpha (TNFα) use among patients with rheumatic diseases
or inflammatory bowel diseases have shown conflicting results. Causal directed acyclic graphs
(cDAGs) are useful tools for understanding the differing results and identifying the structure of potential
contributing biases. Most of the available literature on cDAGs uses language that might be
unfamiliar to clinicians. This article demonstrates how cDAGs can be used to determine whether
there is a confounder, a mediator or collider-stratification bias and when to adjust for them appropriately.
We also use a case study to show how to control for potential biases by drawing a cDAG
depicting anti-TNFα use and its potential to contribute to MS onset. Finally, we describe potential
biases that might have led to contradictory results in previous studies that examined the effect of
anti-TNFα and MS, including confounding, confounding by contraindication, and bias due to
measurement error. Clinicians and researchers should be cognizant of confounding, confounding
by contraindication, and bias due to measurement error when reviewing future studies on the risk
of MS or demyelinating events associated with anti-TNFα use. cDAGs are a useful tool for selecting
variables and identifying the structure of different biases that can affect the validity of observational
studies.
Targeting Glutamine Metabolism through Glutaminase Inhibition Suppresses Cell
Proliferation and Progression in Nasopharyngeal Carcinoma
Authors: Su Chang , Li Minghan , Yang Yuxin , Wang Ziying , Wang Qianru , Wang Weijia , Ma Xuemin , Jie Rongrong , Chen Huaihong , Li Xiangping , Lu Juan
Published: July 2023

Background:

Glutaminase (GLS), the key enzyme involved in glutamine metabolism, has been identified as
a critical player in tumor growth and progression. The GLS inhibitor CB-839 has entered several clinical trials against
a variety of tumors.

Objective:

Our study aimed to investigate the role and underlying mechanism of GLS and its inhibitor CB-839 in nasopharyngeal
carcinoma (NPC).

Methods:

The expression, downstream genes, and signaling pathways of GLS in NPC were determined by real-time
polymerase chain reaction (RT-PCR), PCR array, western blotting (WB), and immunohistochemical staining (IHC),
and the phenotype of GLS was confirmed by in vivo experiments of subcutaneous tumor formation in mice and in vitro
experiments of functional biology, including Cell Counting Kit-8 (CCK-8), colony formation, flow cytometry,
transwell migration, and Boyden invasion assay. Finally, it was also verified whether the treatment of NPC cells by
GLS inhibitor CB-839 can change various biological functions and protein expression to achieve the purpose of blocking
tumor progression.

Results:

GLS was remarkably overexpressed in NPC cells and tissues, predicting a poor overall survival of NPC patients.
GLS promoted cell cycle, proliferation, colony formation, migratory, and invasive capacities by regulating Cyclin
D2 (CCND2) via PI3K/AKT/mTOR pathway in NPC in vitro and in vivo. Notably, CB-839 showed an effective
anti-NPC tumor effect by blocking the biological functions of the tumor.

Conclusion:

The first innovative proof is that GLS promotes cell proliferation by regulating CCND2 via
PI3K/AKT/mTOR pathway in NPC, and GLS inhibitor CB-839 may serve as a new potential therapeutic target for
NPC treatment.
An Update on Herbal Products for the Management of Inflammatory
Bowel Disease
Authors: Arya Himanshu , Dass Rameshwar , Chopra Bhawna , Kriplani Priyanka , Deswal Geeta , Singh Grewal Ajmer , Dhingra Ashwani K. , Kumar Suresh
Published: July 2023

Inflammatory Bowel Disease (IBD), including Ulcerative Colitis (UC) and Crohn's Disease (CD), is a continuously increasing healthcare problem mainly characterized by chronic relapsing intestinal inflammation. The common symptoms of UC and CD include inflamma-tion, diarrhea, abdominal pain, bleeding, and weight loss. IBD is generally caused by an inter-action between genetic and environmental or microbial factors that influence the body's im-mune response and is responsible for digestive disorders and inflammation of the intestinal tract. However, a complete understanding of the pathophysiology and work-up of IBD is neces-sary to ensure appropriate treatment for the management of this complex disease. This review enlightens herbal therapeutics and drug delivery systems for the management of IBD, and thus provides new insights into this field and facilitates access to new treatments.
Tacrolimus and Cyclosporin Pharmacotherapy, Detection Methods,
Cytochrome P450 Enzymes after Heart Transplantation
Authors: Tolou-Ghamari Zahra
Published: July 2023

Background:

Advances in organ transplantation were made after the discovery of the
pure form of cyclosporine by Dr Jean Borel in the 1970s. In fact, in clinical practice achieving a
delicate balance in circulating immunosuppressive necessitate focus on the difficult task of posttransplant
therapeutic drug monitoring.

Objective:

The purpose of this study was to determine the pharmacologic properties of cyclosporine-
tacrolimus, detection methods, and the effects on the activity of cytochrome P450 enzymes
when prescribing the most efficient treatments in forms of polypharmacy for the recipients of heart
transplantation.

Methods:

Scientific literature on the interactions of tacrolimus and cyclosporine with human cytochrome
P450 enzymes was searched using PUBMED.Gov (https://pubmed.ncbi.nlm.nih.gov/),
Web of Science, and Scopus.

Results:

Prescription immunosuppressive drugs based on polypharmacy accompanied by induction
agents could result in hidden neurotoxicity and nephrotoxicity. A literature search shows that
cyclosporine prescription with antihypertensives drugs needs close monitoring. Co-administration
of tacrolimus and diltiazem or verapamil needs a decrease in the tacrolimus dose by 20-50%. Vigilant
attention to the lowest possible statin dose is needed when coadministered with fluvastatin or
pravastatin. Polypharmacy based on ticlopidine, clopidogrel, and cyclosporine or tacrolimus needs
monitoring of immunosuppressive drug levels for several months. A prescription with clotrimazole
or fluconazole needs close monitoring, and itraconazole or ketoconazole needs to reduce the
initial dose by 50%. Combination with nefazodone needs to be avoided, and alternative drugs such
as sertraline or citalopram could be prescribed in addition to further monitoring consideration. In
prescription with phenytoin, the bound and free phenytoin levels need close monitoring.

Conclusion:

Polypharmacy based on tacrolimus or cyclosporine needs vigilant therapeutic drug
monitoring due to the cytochrome P450 enzymes associated with biochemical variables in metabolic
pathways. Further attention to polypharmacy should be given to circulate drugs that could
hide pharmacokinetics interactions associated with infections, malignancies, chronic kidney disease,
and rejection after organ transplantation.
Sterols, Carotenoid and Polyprenols
Authors: Zhang Huidan , Cui Qiu , Song Xiaojin
Published: July 2023

Isoprenoid compounds are a family of compounds constructed with isoprene
as the basic unit but with very different structures, including monoterpenes, diterpenes
and polyterpenes. Isoprenoid compounds mainly include ergosterol, steroids, carotene,
carotenoids, polyisoprene, and their structures range from relatively simple linear
hydrocarbon chains to highly complex cyclic structures, in which the cyclic structure is
cyclized by terpenoids. Enzymes, also known as terpene synthase catalyzed by them,
are also called cyclic terpenes. Isoprenoids are widely distributed in archaea, bacteria,
and eukaryotes, and a variety of isoprenoids are essential components of the biological
mechanism of the organism. For example, in mammals, β-carotene (β-carotene) is the
precursor substance of Vitamin A. β-carotene has the function of preventing oxidation
reactions, and can inhibit and eliminate oxygen free radicals in the body, and has
various effects such as slowing down aging and improving resistance. At the same
time, carotenoids can be combined with protein. Astaxanthin and protein combine to
form astaxanthin, which makes aquatic animals appear body color and has a certain
protective effect. Therefore, ergosterol, steroids, carotene, carotenoids and
polyisoprene, which are relatively large in terpenoids, are all important products with
commercial value and have been widely used in food, medicine, and daily chemical
products.
Health-related quality of life of patients undergoing haemodialysis therapy in Dar es Salaam, Tanzania
Authors: Msilanga Daniel P , Punatar Priyank , Ruggajo Paschal
Published: July 2023

Background: Patients with kidney failure on maintenance haemodialysis therapy have a lower health-related quality of life (HRQOL) than matched controls without kidney failure. HRQOL is an important predictor of clinical outcomes among patients with kidney failure, yet there is a paucity of such data in Tanzania. We determined HRQOL among Tanzanian patients with kidney failure receiving maintenance haemodialysis therapy. Keywords: health-related quality of life, chronic kidney disease, kidney failure, Tanzania
Introdução
Authors: Araújo Sílvia , Doval Herminda Otero , Álvarez Ana Maria Cea
Published: July 2023

O presente volume, número 34 da revista Diacrítica, subordinado à temática das Línguas & Tecnologias: modalidades, desafios e experiência,reúne uma série de artigos que demonstram a eficácia dos novos enfoques metodológicos baseados na aprendizagem ativa. Esses enfoques recorrem a cenários pedagógicos versáteis e interativos implementados em suporte digital com o objetivo de favorecer o desenvolvimento da autonomia e multicompetência dos estudantes alvo.
Exploring Variables Impacting on Employee Willingness to Accept Lower Pay for a Preferred Employer Attribute: Generation, Gender, Race, and Salary
Authors: Fairfax Bucky , Blau Gary , Hill TL
Published: July 2023

We explore the trade-off between “preferred employer attribute” (PEA) and “willingness to accept less pay” (WTALP), finding salary, generational and for-profit versus nonprofit effects on WTALP. Study 1 reports on interviews with 23 professionals about the employer attributes they found most attractive. Three PEAs emerged: people, organizational purpose (purpose), and opportunity for growth and development. Unprompted, interviewees also mentioned willingness to accept lower pay (WTALP) in exchange for attractive job qualities. Study 2 surveyed 129 employees to explore further the PEA-WTALP tradeoff, controlling for gender, race, and salary level before testing for the impact on Generation (Z, Y, X, Baby Boomers) on WTALP, and separately comparing WTALP for-profit versus nonprofit employees. Growth and development PEA was most preferred by 67% (n=86), while 42 respondents selected purpose (n = 34) or people (n =8) PEAs. Regression analysis for the growth and development PEA-WTALP group showed that higher salary level, and Generation Z were associated with higher WTALP. In addition, surprisingly, employment at for-profit firms was associated with higher WTALP. This is the first empirical study measuring scaled levels of WTALP and testing for specific PEA-WTALP combinations. We conclude with future managerial and research implications.
Promoting Freedom Learning Implementation through Self-Determined Learning: A Study of Students' Perspectives
Authors: Sujati Kartika Isna , Syamsudin Amir , Pulungan Delyanti Azzumarito , Apriani Ernita , Puspitaningrum Nimas Putri Dewi
Published: July 2023

This study is aimed to describe the students' perspective towards self-determined learning to promote freedom learning implementation. The survey research design with clustered sampling technique was used to collect 380 senior high school students' responses. The questionnaire that was used in the survey have validated using Pearson Product Moment and reliably known by the Alpha-Cronbach score. Descriptive statistics used as the data analytical technique to describe the senior high students' perspective towards self-determined learning to promote the freedom learning implementation. The results showed that freedom learning fundamental points have similar points with self-determined learning principles consisting of heutagogy and autonomous learning skills. The main conclusion concludes that the students' perspective toward self-determined learning could promote freedom learning implementation. The study's recommendations are be expanded the cluster sampling and be emerged the survey in the case during and after the Covid-19 pandemic the that is indirectly fostering the students' heutagogy and autonomous skill by emphasizing self-determined learning.
Teachers’ enactments of character education: A case study from Indonesia
Authors: Maulana Mochammad Ircham
Published: July 2023

The Indonesian national curriculum and educational policies mandate the integration of character education into every classroom learning activities in schools. This qualitative case study aims to investigate Indonesian subject teachers’ agency to enact character education, including how they plan, assess, and execute it, in their teaching practices. In addition, it also explores the ways they select the character traits as well as the challenges they encountered in character education. The data include in-depth semi-structured interviews with three experienced Indonesian senior high school teachers. The results delineate that the teachers enacted character education that covered cognitive, affective, and behavioural aspects. Nevertheless, these enactments were unplanned and unassessed. In the process of character selection, the teachers reflected on their contextual situations, past experiences, and future orientations. They encountered difficulties in character education due to the abundance of academic materials, and the lack of professional development programs and proactive involvement from other school members.
Penguatan karakter kebangsaan civitas akademika melalui filosofi nama perguruan tinggi
Authors: Mazid Sukron , Sundawa Dadang , Prasetyo Danang
Published: July 2023

Tujuan penelitian ini untuk mengungkap filosofi makna nama Tidar sebagai nama perguruan tinggi. Kandungan makna ini dijadikan pedoman dalam membentuk karakter civitas akademika di kampus. Pendekatan penelitian ini deskriptif kualitatif yang dilaksanakan di Universitas Tidar Magelang dari bulan April sampai Oktober 2022. Subjek penelitian ditentukan dengan cara purposive, yakni sesepuh masyarakat sekitar, mantan Rektor Universitas Tidar, rektor yang menjabat saat penelitian ini dilaksanakan, dan akademisi yang mengetahui tentang filosofi dan makna kata Tidar. Nama ini bukan hanya merujuk pada nama daerah maupun bukit ikonik yang ada di tempat tersesbut, namun ada makna filosofi yang dapat dijadikan rujuakan penguatan karakter kebangsaan. Hasil penelitian ini menemukan adanya makna filosofis dari nama Tidar yang dijadikan sebagai pedoman nilai untuk membentuk karakter civitas akademika di Universitas Tidar. Makna filosofis tersebut adalah: (1) Tangguh, yang mempunyai filosofi makna sulit dikalahkan, kuat, handal, dan tekad; (2) Integratif, yakni jujur, objektif, berani, konsisten dan konsekuen, dan iktikad baik; (3) Dedikatif, yakni pengabdian, dedikasi, daya dukung, dan pengabdian kepada bangsa negara; (4) Aktif yang berarti giat, dinamis, bertenaga, akal yang selalu dikedepankan bukan kekuatan fisik yang mengarah emosional; dan (5) Responsif, yakni sifat cepat merespon, menanggapi, tergugah hati berempati, berusaha mengolah rasa dalam bertindak.This study seeks to reveal the philosophy of the meaning of the name Tidar as the name of a university. The content of this meaning is used as a guide in shaping the character of the academic community on campus. This research approach is descriptive qualitative which was carried out at Tidar University, Magelang from April to October 2022. The research subjects were determined in a purposive manner, namely the elders of the surrounding community, the former Chancellor of Tidar University, the chancellor who served when this research was carried out, and academics who knew about philosophy. and the meaning of the word Tidar, not only referring to the name of the area or the iconic hill in that place. The results of this study found the philosophical meaning of the name Tidar which was used as a value guide to shape the character of the academic community at Tidar University. The philosophical meanings are: (1) Tough, which has a philosophy meaning hard to beat, strong, reliable, and determined; (2) Integrative, namely honest, objective, courageous, consistent and consistent, and in good faith; (3) Dedicative, namely devotion, dedication, power, dedication to the nation and state; (4) Active, which means active, dynamic, powerful, always put forward the mind, not physical strength that leads to emotional; and (5) Responsiveness, namely the nature of being quick to respond, responding, being moved to empathize, trying to cultivate feelings in acting.
Pendidikan karakter melalui karang taruna untuk membangun karakter sosial pada generasi digital native
Authors: Widiatmaka Pipit , Mujahidah Nelly , Rahmap Rahmap , Arifudin Arifudin
Published: July 2023

Tujuan penelitian ini mendeskripsikan implementasi pendidikan karakter melalui kegiatan yang dilakukan di karang taruna yang berperan dalam membangun karakter sosial pada generasi digital native dan menganalisis kendala yang dihadapi karang taruna dalam membangun karakter sosial pada generasi digital native. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Pengumpulan data dalam penelitian ini melalui studi dokumen dan analisis data yang digunakan yaitu analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa pendidikan karakter dapat diimplementasikan di karang taruna, yang merupakan wadah berkumpulnya generasi digital native untuk mengembangkan bakat dan keterampilannya.  Peran karang taruna dalam membangun karakter sosial melalui berbagai kegitan seperti, gotong royong, kegiatan kerohanian, pembinaan dari pengurus, membantu masyarakat yang sedang mengalami kesulitan dan lain sebagainya. Kendala yang dihadapi oleh karang taruna dalam membangun karakter sosial generasi digital native yaitu partisipasi generasi ini mulai menurun karena teknologi internet, intervensi oknum yang memiliki kepentingan politik, dan kurangnya dukungan dari pemerintah khususnya pemerintah desa terhadap kegiatan yang diselenggarakan oleh karang taruna.The purpose of this study is to describe the implementation of character education through activities carried out in Karang Taruna (youth organization), that play a role in building social character in the digital native generation, and to analyze the obstacles faced by Karang Taruna in building social character in the digital native generation. This study uses a qualitative approach with a case study method. The data collection in this study is through document study and the data analysis used is descriptive qualitative analysis. The results of the study show that character education can be implemented in Karang Taruna, which is a gathering place for the digital native generation to develop their talents and skills. The role of Karang Taruna in building social character is through various activities such as mutual cooperation, spiritual activities, coaching from administrators, helping people experiencing difficulties, and so on. The obstacles faced by Karang Taruna in building the social character of the digital native generation is that the participation of this generation has begun to decline due to internet technology, the intervention of individuals with political interests, and the lack of support from the government, especially the village government, for activities organized by Karang Taruna in building social character is very effective through several activities
Studi komparatif pendidikan karakter anak remaja usia 12-15 tahun pada keluarga di suku Boti dalam dan keluarga Kristen di suku Boti luar
Authors: Saingo Yakobus Adi , Natonis Sandro G. , Afi Kristian E. Y. M.
Published: July 2023

Penelitian ini bertujuan menganalisis perbandingan pelaksanaan pendidikan karakter orang tua bagi anak remaja usia 12-15 tahun di Suku Boti Dalam dan suku Boti Luar. Metode yang digunakan yaitu deskriptif kualitatif dengan mewawancarai 5 orang sumber primer terdiri atas 1 orang Raja Boti (Usif), 2 orang tua dari suku Boti Dalam dan 2 orang tua dari suku Boti Luar yang memiliki anak remaja usia 12-15 tahun sehingga diperoleh data yang otentik. Analisis data dilakukan secara komparatif yaitu membandingkan pendidikan karakter yang dilakukan orang tua pada anak remaja usia 12-15 tahun di suku Boti Dalam dengan di Suku Boti Luar. Hasil penelitian menemukan bahwa pendidikan karakter oleh orang tua bagi anak remaja usia 12-15 tahun di suku Boti Dalam sangatlah kental dengan adat-istiadat. Sebagai contoh raja Boti (Usif) melaksanakan pendidikan karakter dengan mengumpulkan masyarakat suku Boti Dalam pada hari ke-9 untuk menasihati, membentuk kelompok kerja, memberikan keteladanan, bercerita, melakukan pembiasan-pembiasaan positif yang dapat mendidik anak remaja. Sedangkah suku Boti Luar dalam melaksanakan pendidikan karakter tidak menghubungkannya dengan adat istiadat, tetapi dengan mendidik anak remajanya sesuai ajaran Alkitab yang menjadi dasar nilai-nilai kekristenan.This study aims to analyze the comparison of the implementation of parental character education for adolescents aged 12-15 years in the Inner Boti Tribe and the Outer Boti Tribe. The method used is qualitative descriptive by interviewing 5 primary sources consisting of 1 Raja Boti (Usif), 2 parents from the Inner Boti tribe and 2 parents from the Outer Boti tribe who have teenagers aged 12-15 years to obtain authentic data. Data analysis was carried out comparatively, namely comparing the character education carried out by parents on adolescents aged 12-15 years in the Inner Boti tribe is very thick with customs. For example, Raja Boti (Usif) carries out character education by gathering the people of the Inner Boti tribe on the 9th day to give advice, form working groups, provide examples, tell stories, make positive habits that can educate teenagers. Whereas the Outer Boti tribe in carrying out character education doesn’t not relate it to customs, but by educating their teenagers according to teachings of the Bible which are the basis of Christian values.
Degradasi moral siswa dalam penerapan nilai-nilai pancasila ditinjau
Authors: Revalina Atiqah , Moeis Isnarmi , Indrawadi Junaidi
Published: July 2023

Penelitian ini bertujuan untuk menganalisis masalah degradasi moral siswa terkait penerapan nilai-nilai Pancasila ditinjau dari makna dan hakikat pendidikan kewarganegaraan (PKn) sebagai pendidikan karakter. Penelitian ini juga mendeskripsikan bentuk-bentuk degradasi moral siswa, faktor penyebab degradasi moral, dan implikasi degradasi moral dalam penerapan nilai-nilai Pancasila. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Data dikumpulkan melalui wawancara, observasi, dan studi dokumen. Hasil penelitian menunjukkan bahwa ada berbagai bentuk degradasi moral siswa dalam penerapan nilai-nilai Pancasila dan yang paling signifikan yaitu: penurunan nilai religius, penurunan nilai kemanusiaan, dan penurunan nilai persatuan. Faktor penyebab degradasi moral siswa yakni lemahnya pengetahuan dan paham nilai-nilai Pancasila, kelalaian orang tua dalam mendidik anak, dan pengaruh gadget atau media sosial. Implikasi dari degradasi moral siswa dalam penerapan nilai-nilai Pancasila, jika ditinjau dari makna dan hakikat PKn sebagai pendidikan karakter, yaitu tidak adanya perilaku yang mengindikasikan hubungan manusia dengan Tuhan, karakter peduli sosial terhadap hubungan hidup sesama manusia, karakter patriotisme dan kebersamaan, karakter demokratis dan adil bagi semua pihak tanpa pandang bulu. This study aims to analyze the problem of students’ moral degradation related to the application of Pancasila values in terms of the meaning and nature of civic education (PKn) as character education. This study also describes the forms of student moral degradation, the factors causing moral degradation, and the implications of moral degradation in the application of Pancasila values. The study uses a qualitative approach with descriptive method. Data was collected through interview, observation, and document study. The results of the study show that there are various forms of student moral degradation in the application of Pancasila values, and the most significant of which are: a decrease in religious valuess, a decrease in human values, and decrease in the values of unity. Factors causing student moral degradation are the lack of knowledge and understanding of Pancasila values, negligence of parents in educating children, and the influence of gadgets or social media. The implications of student moral degradation in applying Pancasila values, when viewed from the meaning and nature of civic education as character education, are namely the absence of behavior that indicates a human relationship with God, the character of social care for the living relationships of fellow human beings, the character of patriotism and togetherness, democratic character and fair to all parties indiscriminately.
PENGARUH PEMBERIAN MIKORIZA, Trichoderma sp., TERHADAP PERTUMBUHAN BAWANG MERAH (CROK KUNING) PADA CEKAMAN KEKERINGAN
Authors: Nawang Bulan Putri Anjani , Ariyanti Nur Aeni , Aloysius Suyitno , Sugiyarto Lili
Published: July 2023

Kekurangan air menyebabkan lahan dalam kondisi cekaman kekeringan sehingga pertumbahan tanaman dapat terhambat. Mikoriza merupakan biostabilizer yang dapat ditambahkan untuk tanaman bertahan. Penelitian ini bertujuan untuk mengetahui pengaruh serta ada tidaknya interaksi pemberian mikoriza dan Trichoderma sp., terhadap pertumbuhan tanaman bawang merah varietas Crok Kuning (Allium cepa L. Aggregatum group) pada berbagai variasi frekuensi penyiraman. Jenis penelitian merupakan eksperimen dengan model Rancangan Acak Lengkap (RAL) dengan dua faktor yaitu pemberian mikoriza (tanpa mikoriza, mikoriza, Trichoderma sp., kombinasi mikoriza + Trichoderma sp.) dan variasi frekuensi penyiraman (setiap hari, 3 hari sekali, dan 6 hari sekali). Parameter pertumbuhan yang diamati adalah tinggi tanaman, jumlah daun, panjang akar berat segar dan kering daun, umbi, akar, dan persentase infeksi mikoriza. Analisis data menggunakan uji Two-Way ANOVA varian faktorial dilanjut uji Duncan apabila perlakuan mikoriza, frekuensi penyiraman, dan interaksi keduanya signifikan. Hasil menunjukkan bahwa tanpa pemberian Trichoderma sp., mampu meningkatkan berat segar daun, umbi, akar, dan berat kering akar, sedangkan perlakuan frekuensi penyiraman memberikan pengaruh terhadap berat segar dan berat kering akar. Adanya interaksi antara pemberian mikoriza dengan frekuensi penyiraman terhadap berat segar daun, berat segar umbi, berat segar akar, dan berat kering akar tanaman bawang merah.
"Fridays for Future": Aksi Mogok Iklim di Freiburg
Authors: Pamerdyatmaja
Published: July 2023

Aksi mogok sekolah Greta Thunberg seorang diri di depan kantor parlemen Swedia pada 2018 dikenal dengan “mogok sekolah untuk iklim” berubah menjadi kesadaran baru di kalangan pemuda, remaja, dan anak-anak di banyak negara. Akibat pengaruh media yang semakin masif memberitakan dinamika aksi mogok tersebut, anak-anak hingga remaja di seluruh dunia pun ikut bersolidaritas dalam aksi mogok sekolah Fridays for Future. Fridays for Future hadir sebagai gerakan lingkungan yang secara rutin mengkritik kebijakan pemerintah yang mengabaikan agenda pengurangan emisi karbon. Berdasarkan penelitian etnografi di Kota Freiburg, Jerman Selatan, artikel ini menceritakan pengorganisasian dan partisipasi gerakan Fridays for Future. Praktik aktivisme ini tidak bisa dilepaskan dari pilihan anak-anak muda mengikuti tren Fridays for Future dan menjadi bagian dari rangkaian sejarah dinamika aktivisme lingkungan yang berlangsung di Kota Freiburg sejak 1968. Atas aktivisme ini, saya mengajukan pertanyaan: mengapa Fridays for Future mampu membentuk keterlibatan sosial sebagian anak muda di kota Freiburg? Artikel ini juga melihat latar belakang budaya dan impian anak muda ketika mereka terlibat dalam aktivisme lingkungan. Saya menerapkan apa yang disebut Goffman (1974) sebagai 'pembingkaian', di mana wacana, narasi, dan praktik-praktik budaya masyarakat sering kali terlihat jelas dalam satu bingkai relasi tertentu, namun terdapat aktivitas yang tidak akan terlihat dari terbatasnya bingkai tersebut. Pada artikel ini, saya berargumen bahwa proses aktivisme lingkungan di Freiburg merupakan praktik ekspresi dari dilema sebagian anak muda yang menumbuhkan ruang-ruang sosial baru di tengah stagnansi aksi yang terbentuk sebagai gerakan moral.
Perspectiva sobre la diferencia de género de pares evaluadores en el contexto de la acreditación universitaria
Authors: Flores Zepeda Margarita
Published: July 2023

A nivel global existen diversos acuerdos sobre la necesidad de cumplir políticas educativas en los procesos enseñanza-aprendizaje, el mejoramiento de la calidad de los sistemas educativos y sus procesos de evaluación y acreditación universitaria. La acreditación de los programas educativos ofertados es realizada por organismos previamente autorizados y con reconocimiento en el campo educativo; en el proceso participan pares evaluadores.
Los trabajos que investigan el papel y las funciones que realizan los académicos universitarios como Pares evaluadores en la evaluación externa, son escasos y aún más los de género enmarcados en sistemas de acreditación de programas e instituciones de educación superior. Ante tal carencia de información sobre la composición de los Organismos Acreditadores (OA), se hace necesario, por interés académico, profundizar en estudios desde la perspectiva de género, esperando lograr conocer si han planteado la equidad de género como parte de sus principios fundamentales.
El estudio busca determinar tanto la proporción de mujeres como la de hombres que integran los Consejos directivos, el Padrón de evaluadores del COPAES y de cada uno de los Organismos Acreditadores para estimar la representación en cuanto a género. Es por ello, que el trabajo se enmarca en académicos que laboran en las instituciones de educación superior del país, por ser ellos los que apoyan las tareas de evaluación de programas educativos. Es de esperarse que la composición de hombres y mujeres en los OA no va a ser equitativa, previendo el predominio masculino.
El artículo está sustentado en una investigación de tipo documental, con un alcance descriptivo, diseño de investigación no experimental, estudio de tipo transversal (observacional, descriptivo y analítico y enfoque cuantitativo.
Metodología ABP como estrategia de apropiación del conocimiento y desarrollo de habilidades digitales durante la pandemia
Authors: Sandoval García Edgar Roberto , Pérez Cárdenas Brenda
Published: July 2023

La metodología ABP incita a los alumnos a tomar decisiones sobre cómo abordar un problema y qué actividades realizar. Con el objetivo de reconocer el impacto de la metodología ABP en la apropiación de nuevos conocimientos y el desarrollo de habilidades digitales de manera virtual por parte de los estudiantes, se elaboró una revista digital interactiva como vía de difusión masiva a temas de interés curricular. El proyecto representó un gran reto para la estudiante a cargo del proyecto al no contar, inicialmente, con las habilidades digitales necesarias para desarrollarlo.
Análisis del sistema de medición por atributos en la inspección de calidad para zarzamoras
Authors: Morfín Magaña Rodrigo , Pulido Toro Eduardo , Corona Soto María de Jesús , Mendoza Ballines Luis Benjamín , Topete Betancourt Karla Cecilia
Published: July 2023

El presente trabajo describe un estudio experimental realizado en empresas empacadoras de zarzamoras con la finalidad de valorar la eficiencia de los sistemas de medición por atributos utilizados. Una característica de este tipo de sistemas de medición es la naturaleza cualitativa y la valoración subjetiva que los inspectores de calidad emplean para valorar los frutos. En el trabajo, se presentan los resultados de análisis de los sistemas de medición por atributos utilizados en dos empresas dedicadas a la actividad de empaque de frutos, las cuales obtuvieron resultados contrastantes en los análisis de concordancia, que son comparados mediante el valor obtenido en el coeficiente estadístico Kappa de Fleiss. Las diferencias obtenidas en los dos casos de estudio son analizadas por medio de datos adicionales que describen características de cada sistema de medición por atributos empleado y que se sugieren como un factor relevante para los resultados obtenidos en cada empresa. El trabajo culmina discutiendo sobre las posibles acciones de mejora para el diseño e implementación de un sistema de medición por atributos en empresas de empaque de zarzamoras.
Haga su diagnóstico
Authors: Trujeque Matos Mariedel , Zurita Rojas Sergio
Published: July 2023

A 68-year-old male patient with constant pain of more than 6 months of evolution in the lumbar region, anemia, elevated serum creatinine, proteinuria and elevated serum calcium.
Material Selection in Electric Vehicle Chassis: A Machine Learning Approach
Authors: R Santhosh Kumar , V Harshit , Sinnasamy Sathya Selvaraj
Published: July 2023

Abstract: This research project focuses on applying machine learning (ML) algorithms for material selection in Electric Vehicle (EV) chassis design. By leveraging ML techniques, we aim to identify suitable materials based on key mechanical properties, enhancing structural performance, safety, and efficiency. Our evaluation of various ML models provides valuable insights for accurate material selection, contributing to the advancement of electric vehicle technology. By considering these evaluation metrics, we gain insights into the effectiveness of the ML models and their potential for accurate material selection in the context of EV chassis design
Penguatan Media Pemasaran Online Dalam Meningkatkan Penjualan Produk Ukm Batik di Kec. Bayat Kab. Klaten
Authors: Nuryakin Nuryakin , Hidayah Nur
Published: July 2023

Kegiatan pengabdian ini dilakukan oleh Tim Program Kemitraan Mayarakat (PKM) yang terdiri dari 2 dosen. Kegiatan ini bertujuan untuk: (1) Mengenalkan kepada para pelaku UKM Batik di Kec Bayat Klaten khususnya pada komunitas pengrajin batik tulis di desa Karang Gumuk RT01 RW 07 Jarum Bayat Timur tentang pemasaran online, (2) Meningkatkan ketrampilan pemasaran melalui media pemasaran online bagi para pelaku UKM Batik di desa Karang Gumuk RT01 RW 07 Jarum Bayat Timur. Kegiatan Program Kemitraan Mayarakat (PKM) ini dilaksanakan selama satu hari dengan alokasi pertemuan selama 4 jam. Materi pelatihan meliputi teori dan praktik cara melakukan penjualan online dengan menggunakan facebook dan instagram. Kegiatan pelatihan ini diikuti sebanyak 16 pelaku UKM Batik di desa Karang Gumuk RT01 RW 07 Jarum Bayat Timur. Metode pelatihan yang digunakan ceramah, diskusi, tanya jawab, demonstrasi, dan praktik secara langsung kepada para pelaku UKM Batik di desa Karang Gumuk RT01 RW 07 Jarum Bayat Timur. Adapun hasil kegiatan PKM ini diantaranya : (1) para peserta mengalami peningkatan pemahaman tentang pemasaran online yang diindikasikan dari peningkatan nilai rerata pre test dan post test peserta dari 56,86 menjadi 78,13. (2) kesan dari para peserta bahwa kegiatan pelatihan memberikan manfaat terhadap kegiatan PPM yang ditunjukkan dari nilai rerata jawaban para post test.