bluuebunny/crossref_metadata_2025 huggingface dataset:
Razrabotka rekombinantnogo onkoliticheskogo shtamma poliovirusa 3-go tipa s izmenennym kletochnym tropizmom
Authors: Хамад А. Н. , Соболева А. В. , Воробьев П. О. , Махмуд М. А. , Василенко К. В. , Чумаков П. М. , Липатова А. В.
Published: May 2022

Diffuznaya glioma yavlyaetsya neizlechimym zabolevaniem, naibolee rasprostranennym i agressivnym tipom opuholej CNS. Razrabotka vysokoonkoselektivnyh virusnyh shtammov dlya terapii zlokachestvennyh novoobrazovanij yavlyaetsya aktual'noj zadachej. Cel'yu raboty bylo sozdanie onkoliticheskogo virusa na baze vakcinnogo shtamma poliovirusa 3 tipa, obladayushchego prirodnoj protivoopuholevoj aktivnost'yu, putem zameny IRES poliovirusa sootvetstvuyushchim uchastkom iz rinovirusa cheloveka 30 tipa. V rezul'tate byl uspeshno poluchen rekombinantnyj onkoliticheskij shtamm RVP3, sohranivshij serotip poliovirusa 3 tipa, chto bylo podtverzhdeno mikroreakciej nejtralizacii specificheskoj antisyvorotkoj. Onkoliticheskaya effektivnost' RVP3 byla ocenena in vitro na shirokoj paneli kletochnyh kul'tur. RVP3 izmenil tropizm, poteryav sposobnost' effektivno replicirovat'sya v uslovno normal'nyh kletochnyh liniyah embrional'nyh astrocitov i embrional'nyh fibroblastov, sohraniv sposobnost' effektivno replicirovat'sya v opuholevyh kletkah.
A qualidade da oferta e do acesso ao ensino superior de graduação no brasil segundo as estratégias das metas 12 e 13 do plano nacional de educação
Authors: Ramos de Azevedo Alexandre , Zalaf Caseiro Luiz Carlos
Published: May 2022

Explicitando o objetivo central da Meta 13 do PNE, a elevação da qualidade do ensino de graduação, o artigo investiga o conceito de qualidade aplicado à educação superior, inicialmente concebido como um conceito complexo, polissêmico e não consensual. A revisão da literatura especializada e da legislação identificou três visões ou perspectivas de qualidade – econômica, social e da diversidade – com base nas quais foi apresentada uma proposta preliminar de indicadores complementares ao monitoramento das metas 12 e 13 do PNE e suas estratégias. Observou-se que as estratégias da Meta 13 contribuíram para a identificação de dimensões de qualidade econômica e/ou referenciada em padrões, enquanto as estratégias da Meta 12 possibilitaram olhar para as dimensões de qualidade social e/ou de equidade. O texto conclui pela defesa de uma perspectiva de qualidade cada vez mais pluralista e/ou da diversidade, resultante da composição abrangente de um mosaico de qualidade na educação superior, englobando dimensões que representem tanto uma visão econômica quanto uma visão social, o que é mais condizente com as responsabilidades e desafios que se colocam para as políticas de educação superior da atualidade.
A Functional Equation with Biadditive Functions
Authors: Łukasik Radosław
Published: May 2022

Let S, H, X be groups. For two given biadditive functions A : S
2 → X, B : H
2 → X and for two unknown mappings T : S → H, g : S → S we will study the functional equation

B(T (x), T (y)) = A(x, g(y)), x, y ∈ S,

which is a generalization of the orthogonality equation in Hilbert spaces.
Effect of dietary β-Mannanase addition on performance, pododermatitis, and intestinal morphology as well as digesta Clostridium perfringens in broiler chickens: a pilot study
Authors: El-Wahab Amr Abd , ElMetwaly Ahmed Marwa Fawzy , Reckels Bernd , Schiel Benjamin , Visscher Christian , Kamphues Josef
Published: May 2022

This preliminary study was conducted to evaluate the effects of β-mannanase in diets of broilers on performance, pododermatitis, intestinal morphology, and digesta Clostridium perfringens counts. A total of 264 broilers (Ross 308) were randomly allotted to four treatments. A wheat-soybean based diet (CO) was supplemented with either 0.15 g xylanase/kg (XY), 0.15 g xylanase/kg + 110 mL β-mannanase/ton (MA1) or 0.15 g xylanase/kg + 220 mL β-mannanase/ton (MA2). At the end of the experiment, only significant differences in body weight were noted between groups fed MA1 and MA2 diets (2501 g vs 2641 g, respectively). Birds fed MA1 had significantly the lowest pododermatitis scores (2.26) compared to other groups. Ileal villus height measurements revealed that birds fed CO and MA2 diets had significantly higher values (1614 and 1651 µm, respectively) than those fed the MA1 diet (1489 µm). The positive percent of Clostridium perfringens in intestinal digesta at d 36 was significantly the highest in the XY group. Overall, although not improving performance, supplementing the diet with β-mannanase (110 mL/ton) contributed positively to foot pad health.
Surface, Elemental and Electrochemical Characterizations of Ancient Coins By Non – Destructive Techniques
Authors: Ion Rodica-Mariana , David Mădălina Elena , Gheboianu Anca Irina
Published: April 2022

The cultural heritage field represents a witness to artifacts values in a continuous evolution, it strongly influences our sense of identity and our behavior as people. To protect these archaeological treasures, different conservation and restoration methods are required. Considering the field of priceless artifacts, our research direction led us to preliminary studies of metallic coins from 20th century through non–destructive techniques. Copper–based coins were subjected to the surface characterization through optical microscopy (OM) in transmitted light, elemental composition analysis using Wavelength Dispersive X-ray Fluorescence (WDXRF) and electrochemical corrosion using Tafel extrapolarization technique. The microscopic investigations showed that the patina layer is due to presence of copper content in coins composition confirmed by X-ray fluorescence spectroscopy technique. Also, the electrochemical tests disclosed different corrosion rate according to each chemical composition of coins. This study provide a broad overview of ancient coins to preserve their value in the future.
Virtual Studies on the Behavior of Polyurethane on Mechanical Stresses
Authors: Negrea Alexis , Enescu Maria Cristiana , Stoian Elena Valentina , Petre Ivona
Published: April 2022

In this part of the paper, we will study the behavior of PUR polyurethane at different mechanical and thermal stresses, stresses for which this material behaves very well. It is known that this material behaves well as a protective material against shocks, so it is used as protection against mechanical elements. PUR behaves excellently at uneven static stresses and dynamic stresses. That is why it is used in the construction of the rollers of medium weight mobile devices or rollers that have cam functionality, strongly required for static and dynamic contact. PUR has very good thermal properties, it is used as a thermal insulator when it is in the form of high-density polyurethane foam (PUR / PIR).
Pyridoxamine alleviates high glucose induced fibrosis in renal tubular epithelial cell by inhibiting the activity of TGF-β1/Smad3 signaling pathway
Authors: Wang Ziqiang , Li Ying , Wang Ying , Zhao Kunxiao , Chi Yanqing , Wang Baoxing
Published: April 2022

Background

Renal fibrosis is one of the main characteristics of diabetic nephropathy. TGF-β1/Smad3 pathway is expected to reveal the pathogenesis of renal fibrosis in diabetic nephropathy (DN). Pyridoxamine (PM), a natural form of vitamin B6, is a powerful inhibitor of advanced glycation end products (AGEs). PM plays an anti-apoptotic, anti-oxidative stress, and fibrosis role in DN. The purpose of this study was to assess whether PM has a protective effect in renal tubular epithelial and to investigate its possible mechanism.

Methods

The effects of PM were investigated in HK-2 cells induced by high glucose. HK-2 cells were administered with PM at a dose of 1 mmol/L. Western blot and Realtime PCR were used to detect the expression levels of renal fibrosis related proteins. The possible mechanism of PM was examined by expression of transforming growth factor-β1 (TGF-β1)/Smad3 pathway.

Results

PM could reduce the expression of Fibronectin (FN) and α-smooth muscle actin (α-SMA) induced by high glucose. PM could also affect the activity of TGF-β1/Smad3 pathway in HK-2 cells. FN and α-SMA were up-regulated by overexpression of Smad3 for 48 h. After adding PM, the levels of FN and α-SMA are significantly decreased.

Conclusion

Our findings indicate that PM showed a protective effect in HK-2 cells through the inhibition of TGF-β1/Smad3 pathway.
The hydroperoxyl antiradical activity of Trolox in water: The effects of pH values on rate constants
Authors: Hoa Nguyen Thi
Published: April 2022

Trolox (6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid) is a highly hydrophilic α-tocopherol analog that is widely used as a standard against which the antioxidant ability of other chemicals is measured and represented in Trolox equivalents. However, the effect of pH values on the hydroxyl radical scavenging activity has not been fully studied yet. In this study, the HOO• antiradical activity of Trolox in water was studied. It was found that the H-abstraction of the O1-H bond determined the activity of the neutral and monoanion states, whereas the electron transfer reaction of the hydroxyl anion state determined the activity of the dianion state. Although the total rate constant increased following the increase in pH levels, the overall rate constant of the Trolox + HOO• reaction in water changed when pH levels rose due to the decrease in HOO• molar fraction. The results also revealed that at pH < 2, the O1-radical was the main intermediate of the Trolox + HOO• reaction in water, whereas, at pH ---gt--- 5, the anion-radical was the significant intermediate. Thus the rate constants and the reaction intermediates vary with the pH values.
Genetically modified mice for research on human diseases: A triumph for Biotechnology or a work in progress?
Authors: Brown Richard E.
Published: April 2022

Genetically modified mice are engineered as models for human diseases. These mouse models include inbred strains, mutants, gene knockouts, gene knockins, and ‘humanized’ mice. Each mouse model is engineered to mimic a specific disease based on a theory of the genetic basis of that disease. For example, to test the amyloid theory of Alzheimer’s disease, mice with amyloid precursor protein genes are engineered, and to test the tau theory, mice with tau genes are engineered. This paper discusses the importance of mouse models in basic research, drug discovery, and translational research, and examines the question of how to define the “best” mouse model of a disease. The critiques of animal models and the caveats in translating the results from animal models to the treatment of human disease are discussed. Since many diseases are heritable, multigenic, age-related and experience-dependent, resulting from multiple gene-gene and gene-environment interactions, it will be essential to develop mouse models that reflect these genetic, epigenetic and environmental factors from a developmental perspective. Such models would provide further insight into disease emergence, progression and the ability to model two-hit and multi-hit theories of disease. The summary examines the biotechnology for creating genetically modified mice which reflect these factors and how they might be used to discover new treatments for complex human diseases such as cancers, neurodevelopmental and neurodegenerative diseases.
Bredemolic acid restores glucose utilization and attenuates oxidative stress in palmitic acid-induced insulin-resistant C2C12 cells
Authors: Matee Karabo R. , Akinnuga Akinjide M. , Siboto Angezwa , Ngubane Phikelelani , Khathi Andile
Published: April 2022

Objective. Due to insulin resistance and oxidative stress that are associated with type 2 diabetes mellitus (T2DM), T2DM has become a prevalent metabolic disorder that presents various side effects. However, alternative antidiabetic treatment has commonly been used in treating diabetes mellitus in diabetic patients. In our previous studies, bredemolic acid has been reported as an antidiabetic agent that improves glucose uptake, ameliorates insulin resistance, and oxidative stress in the liver, heart, kidney, and skeletal muscle of prediabetic rats. However, these effects have not been validated in vitro. Therefore, this study was aimed to investigate the effects of bredemolic acid on insulin-mediated glucose utilization, lipid peroxidation, and the total antioxidant capacity (TOAC) in palmitic acid-induced insulin-resistant C2C12 skeletal muscle cells in vitro.

Methods. Insulin resistance was induced in the skeletal muscle cells after 4 h of exposure to palmitic acid (0.5 mmol/l). Different cell groups were incubated in culture media DMEM supplemented with fetal calf serum (10%), penicillin/streptomycin (1%), and L-glutamine (1%) and then treated with either insulin (4 µg/ml) or bredemolic acid (12.5 mmol/l) or with both. Thereafter, the cells were seeded in 24- or 96-well plates for determination of the cell viability, glucose utilization, glycogen formation, and antioxidant capacity.

Results. The results showed that bredemolic acid significantly improved TOAC and promoted glucose utilization via attenuation of lipid peroxidation and increased glycogen formation in the insulin-resistant cells, respectively.

Conclusion. This study showed that bredemolic acid restored the insulin resistance through improved glucose utilization, glycogen formation, and TOAC in the skeletal muscle cells.
Rheumatoid arthritis: current therapeutics compendium
Authors: Dariushnejad Hassan , Chodari Leila , Sedighi Mehrnoosh , Akbari Soheila , Ghorbanzadeh Vajihe
Published: April 2022

Rheumatoid arthritis is a common chronic inflammatory disease with substantial economic, social, and personal costs. Its pathogenesis is multifactorial and complex. The ultimate goal of rheumatoid arthritis treatment is stopping or slowing down the disease progression. In the past two decades, invention of new medicines, especially biologic agents, revolutionized the management of this disease. These agents have been associated with an improved prognosis and clinical remission, especially in patients who did not respond to traditional disease-modifying anti-rheumatic drugs (DMARDs). Improvement in the understanding of the rheumatoid arthritis pathogenesis leads to the development of novel biologic therapeutic approaches. In the present paper, we summarized the current therapeutics, especially biologic agents, available for the treatment of rheumatoid arthritis.
Measures to reduce stress in the workplace – results from focus group interviews with health professionals / Maßnahmen zur Reduktion von Stress am Arbeitsplatz – Resultate aus Fokusgruppeninterviews mit Gesundheitsfachpersonen
Authors: Golz Christoph , Renggli Fabienne Josefine , Gurtner Caroline , Peter Karin Anne
Published: April 2022

Introduction

Stress and poor working conditions can affect the health and satisfaction of health professionals. Until now, the perspective of the staff has not been sufficiently considered in the development of solutions. The aim was to capture the wishes and recommendations of health professionals that could contribute to an improvement of the work situation from their perspective.

Method

Semistructured focus group interviews with health professionals (nurses, midwifes, medical-technical-therapeutic professions and physicians) were conducted and analyzed using knowledge mapping and a deductive approach.

Results

Between June and November 2018, 128 health professionals from Swiss acute hospitals, psychiatric hospitals, nursing homes, and outpatient services participated in a total of 24 focus group interviews. They expressed the need to incorporate wishes into staff scheduling and to address vacation planning at an early stage. Other suggestions were to be able to take advantage of further training opportunities and to live a positive feedback and error culture, as well as to establish a clear division of roles and tasks.

Conclusions

The healthcare staff interviewed showed clear ideas about what should be improved to reduce workload. There is a great need for action in the general conditions as well as in leadership and management.
Bank-Specific and Macroeconomic Determinants of Bank Liquidity Creation: Evidence from MENA Countries
Authors: Mdaghri Anas Alaoui , Oubdi Lahsen
Published: April 2022

This study measures liquidity creation within a sample of 153 banks operating in 12 Middle Eastern and North African (MENA) countries from 2008 to 2017. We found that these banks created a total of $461.32 billion in liquidity in 2017, approximately 1.51 times the total liquidity created in 2008, mainly driven by commercial banks in Gulf Cooperation Council (GCC) countries. We also conducted an econometric analysis to investigate the internal and external factors affecting bank liquidity creation, applying a Fixed Effects model and the new Method of Moments Quantile Regression (MMQR). The results show that, among bank-specific factors, bank liquidity creation in MENA countries is related to capital, size, bank risk, deposits and profitability whilst market concentration does not appear to play a significant role. Regarding macroeconomic factors, inflation, unemployment, savings and monetary policy explain the variations in bank liquidity creation.
Adaptive Early Warning Systems: An Axiomatic Approach
Authors: Bhimjee Diptes C. P.
Published: April 2022

The U.S. Subprime Crisis and the subsequent Great Recession have highlighted a renewed interest in the proper design and implementation of Early Warning Systems (E.W.S.), in order to help deter the onset of subsequent extreme financial events, through the implementation of adequate crisis detection mechanisms. The present article describes the Adaptive Early Warning Systems (A.E.W.S.) axiomatic approach, as a natural operational extension to E.W.S. testing. This novel protocol upholds the operational dimension of implementing an efficient holistic crisis detection mechanism, a domain which has been hitherto overlooked by the E.W.S. literature. The paper first describes the major axiomatic principles sustaining the A.E.W.S. protocol, which seek to establish universal principles in support of the said protocol. Second, the article also describes a basic universal template for an A.E.W.S. surveillance platform, which duly describes how multiple testing procedures can be integrated into a single crisis detection framework, while targeting multiple segments of the financial markets (such as the conventional and non-conventional segments of the financial markets). Third, the paper also describes the major advantages and disadvantages associated with the implementation of this novel protocol. It is hoped that the effective implementation of the A.E.W.S. protocol as a novel operational framework in the global macroprudential toolkit might help deter the onset of future extreme financial events, by enabling a greater cohesiveness in E.W.S.-related central banking procedures, as well as promoting a greater international central banking cooperation prior to and during financial distress episodes.
An Application of Index Number Theory to Interest Rates: Evidence from Selected Post-Soviet Countries
Authors: Poghosyan Karen , Poghosyan Ruben
Published: April 2022

In this paper, we use index number theory to decompose changes in total interest rate due to changes in the interest rate component and the weight component. We discuss the optimal calculation of a binary index using axiomatic index number theory. Based on this theory we compare alternative indexes and as a result, we choose the Marshall-Edgeworth index because most axioms are satisfied by this index. Comparing the results of binary periods decomposition, we conclude that the differences are not significant when we apply different indices. For multiple period comparison, we suggest using the chain index because it allows accounting for the weights evolution during the whole period. In addition, we derive a formula that could be useful for explaining the differences between chain and direct indexes when we produce multiple period comparison.
The Model of a Shared Interest Rate for a Group of Countries to Circulate a Digital Currency: Featuring the BRICS
Authors: Zharikov Mikhail V.
Published: April 2022

The purpose of the research is to offer a comparative analysis of a libertarian and gradual approach to introducing a market interest rate. The topic is time-relevant since the economies of the emerging markets today face difficult challenges posed by economic, financial and health-care crises, impending price stability, future growth and money market equilibrium. A digital currency is a special issue today due to the outbreak of covid-19, which has made many central banks think about contactless means of payment. The author revealed policy tools to circulate a hypothetical digital currency for the BRICS, including a shared interest rate and the quantity of digital money in circulation needed for the penta-lateral use. The theoretical significance is that the research tries to lay the foundation for a model to launch a virtual regional money market for the countries of the BRICS as well as their partners in wider parts of Europe and Asia. In practical terms, the article recommends a number of tools for monetary policy to deal with the coronavirus crisis of 2020.
Al2O3-TiO2 coatings deposition by intermixed and double injection SPS concepts
Authors: Nowakowska Monika , Sokołowski Paweł , Tesař Tomáš , Mušálek Radek , Kiełczawa Tomasz
Published: April 2022

This work focuses on the study on the novel hybrid method of simultaneous spraying from two different materials (Al2O3 and TiO2) by means of suspension plasma spraying (SPS) using submicron powder and water suspension. The goal was to attempt the deposition of intermixed alumina-titania coatings, namely: Al2O3 + 3 wt.% TiO2, Al2O3 + 13 wt.% TiO2, and Al2O3 + 40 wt.% TiO2. Such compositions are already used but in the form of conventionally plasma sprayed coatings, with micrometer-sized powder. Meanwhile, the injection of feedstocks with submicron-sized particles has not been established yet. In particular, this paper uses two routes of feedstock injection, (i) with the use of an intermixed suspension and (ii) a double injection of separate suspensions. The attention was paid to the characterization of the feedstock materials, description of deposition parameters as well as the morphology, microstructure, and phase composition of the obtained coatings. Among all coatings, Al2O3 + 40 wt.% TiO2 sprayed with double injection contained the most homogeneously distributed and melted splats. The results from this work demonstrate the possibility of coating deposition both by intermixed and double injection concepts but also the need for the further application-relevant optimization, related to the presence of intercolumnar gaps in the microstructure of the coatings.
Huge parapharyngeal space tumor: Case report and short literature review
Authors: Tillashayhov Mirzagolib , Khasanov Akbar , Nishonboev Latifjon , Amonov Anvar , Bekmirzaev Rahimjon , Shukurov Zohir , Hudoyorov Murod
Published: April 2022

The parapharyngeal space (PPS) has a special anatomical and clinical importance from the point of view of its content, communication and vicinity with major and vital structures. Tumors of the parapharyngeal space are uncommon, the most incriminated being the salivary gland tumors, neurogenic tumors, especially Schwannomas and paragangliomas, and lymphoreticular lesions. The correct diagnosis of the PPS tumors must include the radiologic evaluation represented by the computed tomography (CT) and the magnetic resonance imaging (MRI). The therapeutic plan depends on the imagistically identified aspect. We report a case of a 40-year-old male, who initially noted a massive tumor of the left side of the neck within 15 years. The cervical CT scan revealed, in the upper third of the left side of the neck, in the projection of the parotid and masticatory space and the submandibular region, under the lower jaw, medially at the level of cervical vertebrae C1 – C4, to the front of the sternocleidomastoid muscle, a volumetric formation irregular in shape, with clear and uneven contours, dimensions 40x65x85 mm, uniform density +30H. Transverse cervical approach was chosen for the surgical investigation.
Acteurs et processus autour de l’héritage : l’Opéra d’État de Vienne, un exemple à plusieurs échelles (1869–1955)
Authors: Scherer Solène
Published: April 2022

Un lien semble s’être noué entre histoire, identité, nation et territoire depuis le XIXe siècle. Dans l’acception contemporaine du mot, le patrimoine, terme parapluie, désigne autant les biens du passé prestigieux – monuments et œuvres d’art – que les éléments folkloriques, mais aussi les paysages. L’importance du patrimoine dans l’ancrage du sentiment d’appartenance est telle qu’il nous est désormais impossible de dissocier les éléments patrimoniaux de nos conceptions d’un territoire. Il s’agit ici d’analyser comment la patrimonialisation, en tant que processus de construction sociale, politique, économique d’une reconnaissance de valeurs autour d’une entité – objet, bâtiment, lieu, pratique traditionnelle – peut engendrer une réappropriation du territoire au sein duquel cette entité évolue. À l’aide d’un exemple, l’Opéra de Vienne, nous analyserons les étapes du processus de patrimonialisation, pour en comprendre la dynamique et les acteurs, déclinant l’héritage tant sur le plan temporel que spatial. Cet exemple nous permet aussi d’observer les processus de patrimonialisation à plusieurs échelles : régionales, nationales et internationales.
Metode Pembelajaran Suling Laras Slendro Gaya Yogyakarta
Authors: Marsudi Marsudi Marsudi
Published: April 2022

This research is motivated by the fact that many flute players, artists, musical practitioners and students do not recognize the characteristics of the Yogyakarta style flute, so there is a tendency to abandon it. On the other hand, the Yogyakarta style flute instrument has specifications that lead to special characteristics. This study aims to provide an understanding of the Yogyakarta style flute as well as produce teaching materials for the Yogyakarta style flute as a guide for learning. This study uses two methods, namely data collection and analysis and design methods. Yogyakarta Style flute learning techniques include: knowledge of the flute, basic techniques, intermediate techniques, and advanced techniques. Knowledge of the flute includes the characteristics of the shape, blow hole, tone hole, closing tone, cengkok seleh, and the application of cengkok seleh flute Yogyakarta style. Basic techniques include mastery of blowing and closing types in finding the tone of both the slendro  barrels. Intermediate techniques include basic mastery of crooked selh, slendro barrel and pelog barrel. Advanced techniques include the application of seleh bends on the gending and lagon.
PENGARUH STORY TELLING TENTANG KESIAPAN MENGHADAPI BENCANA GEMPA BUMI TERHADAP SELF EFFICACY ANAK PRASEKOLAH
Authors: Ririnisahawaitun Ririnisahawaitun , Yuliyanti Sasteri , Farlina Baiq Fina , Junardi Hariawan
Published: April 2022

The located in the Pasific ring of fire, Indonesia has high potential for disaster, such as earthquakes. Children are a vulnerable group to be victim. Self efficacy is needed to make  children have ability to act when disaster occurs. One of the effort to improve children’s self efficacy is by story telling. The aim of this study is to determine the effect of story telling about earthquake preparedness toward self efficacy of preschool. This study was a pre-experimental study, with a one pretest-posttest group design. The population of this study was all children in Childhood School at Tulus Ikhlas Al Habibi, Batuyang Village, Pringgabaya, East Lombok of 60 children was taken by total sampling. Collecting data using a self efficacy questionnaire was validity and reliability test. The intervention in this study was story telling using hand puppet media. Wilcoxon test showed there were the effect of story telling about earthquake preparedness toward children’s self efficacy (p value = 0,000).
HUBUNGAN TINGKAT PENDIDIKAN IBU DENGAN KONSUMSI SAYUR DAN BUAH PADA ANAK PRASEKOLAH
Authors: Anggreny Yecy , Niriyah Sekani
Published: April 2022

Low levels of vegetable and fruit consumption made preschooler susceptible to disease. This study aimed to find out the relationship of maternal education levels to vegetable and fruit consumption in preschooler. The research method was a type of analytical quantitative research, with a correlation design and a cross-sectional approach. This research was conducted at Payung Sekaki Public Health Center. Sample of this study were 192 mothers who had a preschooler. Sampling techniques used purposive sampling. The data was collected by using questionnaire which was created by researchers and had been tested for validity and reliability before. Data was analyzed by using chi-square test. The results of the bivariate analysis obtained a value of 0,045 (< 0,05) which means there was a significant relationship between maternal education levels and vegetable and fruit consumption. Thus, the public health center was expect to provide education and health information to mothers about how to serve food for preschooler which more interesting and nutritious.
DUKUNGAN TENAGA KESEHATAN DAN SUAMI DENGAN KEPATUHAN PELAKSANAAN KB DI MASA PANDEMI COVID-19
Authors: Adkhana Sari Dian Nur , Nurdiasti Yesita , Kusumasari Viantika , Timiyatun Endar
Published: April 2022

The Covid-19 pandemic has had an impact on the Family Planning Program, namely the decline in participants. The decreased participants of program cause a high risk of pregnancy which will cause problems with the explosion in the number of infant births. To overcome this impact, support from health workers and husbands is needed to help improve acceptor compliance in implementing the program during the Covid-19 pandemic. This study aimed to determine the relationship between the support of health workers and husbands with family planning implementation during the Covid-19 pandemic at the Kalasan Sleman Health Center. Cross-sectional design with accidental sampling was used. 52 family planning acceptors were recruited. Chi Square analysis and multiple linear regression was performed. This study used three research instruments, namely the family planning card to measure compliance with family planning implementation, the health worker support questionnaire to measure the support of health workers and the husband's support questionnaire to determine the husband's support for family planning acceptors at the Kalasan Health Center, Sleman Yogyakarta. The results of the chi square test obtained the p value = 0,000 and the contingency coefficient value of 0,537 (support of health workers) and 0,679 (support of husband). Thus, there is a relationship between the support of health workers and husbands with compliance with the implementation of Family Planning Program during the Covid-19 pandemic at the Kalasan Health Center, Sleman Yogyakarta.
HUBUNGAN STRES AKADEMIK DENGAN KUALITAS TIDUR PADA MAHASISWA KEPERAWATAN UNIVERSITAS UDAYANA
Authors: Tari Made Ayu Tara Sania , Kamayani Made Oka Ari , S Made Rini Damayanti
Published: April 2022

Academic stress is stress related to educational activities. The cause of academic stress is the inability of individuals to make adjustments to academic demands. There are factors influence sleep quality such as academic stress. This study aimed at identifying the relationship between academic stress and sleep quality among nursing students at Udayana University. This was a quantitative correlative study using a cross-sectional design. The research sample in this study was 163 respondents who were selected by stratified random sampling technique. The independent variable of this study is academic stress while the dependent variable is sleep quality. The data were collected by the Educational Stress Scale for Adolescents (ESSA) dan Pittsburgh Sleep Quality Index (PSQI) questionnaires. The results showed 55 students (33,7%) had very high academic stress and 118 students (72,4%) had poor sleep quality. Data were analyzed using Spearman Rank correlation test. The result of the correlation test showed that there was a relationship between academic stress and sleep quality with a weak correlation and the direction of the correlation was positive (r = 0,236; p = 0,002), which means the higher the academic stress, the worse the sleep quality.
GAMBARAN TINGKAT STRES ORANG TUA SISWA SEKOLAH DASAR SELAMA PEMBELAJARAN JARAK JAUH DI MASA PANDEMI COVID-19
Authors: Darmayanti Ni Made Sri , Sawitri Ni Komang Ari , Swedarma Kadek Eka
Published: April 2022

Some parents experience obstacles during distance learning such as difficulties in motivating or improving children's mood to learn, difficulties in teaching children, quota and network constraints, and difficulties in assisting children in learning. The purpose of this study was to describe the stress level of parents of SD Negeri X students in connection with distance learning during the COVID-19 pandemic. This research is a quantitative descriptive study by distributing online questionnaires to 85 parents of SD Negeri X students using proportionate stratified random sampling technique. The measuring instrument used was a Perceived Stress Scale 10 questionnaires which has been modified by the researcher. Based on the results of the study, it was found that the median age of parents is 37 years with the youngest age being 24 years old, and the oldest age being 61 years old. The majority of the parents are female, with high school education, with working status, coming from middle income group, only use one facility in the form of a handphone, with smooth internet network condition, with subsidized quota, can use learning applications independently, and class II and IV. The majority of stress levels from parents is moderate stress.
HUBUNGAN KECERDASAN EMOSIONAL DENGAN BURNOUT SYNDROME PADA MAHASISWA YANG MENJALANI PEMBELAJARAN DARING
Authors: Widayana I Gede Angga Ariesta , Suarningsih Ni Kadek Ayu , Utami Kadek Cahya
Published: April 2022

Changes in the online learning system have potential to cause burnout syndrome. This study aimed to investigate the correlation between emotional intelligent with burnout syndrome among student in Faculty of Medicine, Udayana University who ware ongoing in online learning. This research is quantitative research with descriptive correlative. The research design used is cross sectional. Sample on this study were 243 sample selected through proportionate stratified random sampling. Collecting data using Trait Emotional Intelligence Questionnaire - Adolescent Short Form and Maslach Burnout Inventory-Student Survey. Data analysis using Spearman Rank test. The results showed that there is negative and weak correlation between emotional intelligent with burnout syndrome. It means that the higher of emotional intelligence will decrease the burnout syndrome and otherwise.
PENGARUH ECONOMIC VALUE ADDED DAN MARKET VALUE ADDED TERHADAP RETURN SAHAM
Authors: Delia Delia , Sidik Solihin
Published: April 2022

Masalah dalam penelitian ini adalah untuk mengetahui, menganalisa dan mengkaji pengaruh secara parsial dan simultan Economic Value Added dan Market Value Added terhadap Return Saham Perusahaan Subsektor Farmasi yang terdaftar di BEI Periode 2015 - 2019. Jumlah sampel yang diambil adalah 8 (delapan) perusahaan subsektor Farmasi yang terdaftar di BEI dan telah mempublikasikan laporan keuangan tahunan secara lengkap pada periode penelitian. Teknik sampling yang digunakan adalah Purposive Sampling. Penelitian ini diharapkan dapat memberikan sumbangan bagi pengembangan bidang akuntansi khususnya akuntansi keuangan. Metode penelitian yang digunakan adalah metode kuantitatif dengan analisis deskriptif verifikatif. Berdasarkan hasil analisis data penelitian diperoleh beberapa kesimpulan sebagai berikut : Economic Value Added (EVA) secara parsial berpengaruh negatif signifikan terhadap return saham perusahaan farmasi yang terdaftar di BEI pada periode penelitian. Dan Market Value Added (MVA) secara parsial berpengaruh positif signifikan terhadap return saham perusahaan farmasi yang terdaftar di BEI pada periode penelitian. Economic Value Added (EVA) dan Market Value Added (MVA) berpengaruh positif dan signifikan secara simultan terhadap return saham perusahaan farmasi yang terdaftar di Bursa Efek Indonesia pada periode penelitian.
PENGARUH SANKSI PAJAK DAN KEADILAN PAJAK TERHADAP PERSEPSI MAHASISWA AKUNTANSI MENGENAI PENGGELAPAN PAJAK
Authors: Purnayasa I Kadek Wage
Published: April 2022

Ketika sanksi pajak dirasa memberatkan, hal tersebut dapat mendorong wajib pajak melakukan tindak penggelapan pajak. Jika suatu keadilan yang berlaku tidak sesuai dengan norma, wajib pajak akan melegitimasi tindakan untuk melakukan tindakan penggelapan pajak. Penelitian ini bertujuan untuk mengetahui pengaruh sanksi pajak dan keadilan pajak terhadap persepsi mahasiswa mengenai penggelapan pajak. Penelitian ini dilakukan di jurusan akuntansi Fakultas Ekonomi dan Bisnis Universitas Udayana. Populasi penelitian ini yaitu mahasiswa jurusan akuntansi FEB Universitas Udayana tahun angkatan 2017. Sampel yang digunakan sebanyak 100 sampel. Metode penentuan sampel yang digunakan dalam penelitian ini adalah metode nonprobability sampling dengan teknik accidental sampling, yaitu teknik penentuan sampel dengan peneliti dapat memilih orang-orang yang dekat dengannya atau memilih responden yang pertama kali berhasil dijumpai. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi linear berganda. Hasil uji dalam penelitian ini menemukan bahwa sanksi pajak berpengaruh positif dan signifikan terhadap penggelapan pajak dan keadilan pajak berpengaruh positif dan signifikan terhadap penggelapan pajak. Hal ini menunjukkan bahwa semakin tinggi sanksi pajak dan keadilan pajak maka akan meningkatkan persepsi mahasiswa akuntansi mengenai penggelapan pajak.
Кулайское погребение в лодке на Барсовой Горе
Authors: Чемякин Юрий Петрович
Published: April 2022

Публикуются материалы одного из погребений могильника раннего железного века, открытого недалеко от г. Сургута. Оно было совершено в лодке. По количеству положенных вещей это вторая по богатству могила на памятнике. Погребальный инвентарь в ней представлен украшениями, фрагментами блях, зеркал и пластин из цветного металла, в том числе с гравировками, деревянными фигурками, железным изделием в костяной рукояти, сосудом. Памятник относится к кулайской культуре и датируется началом I тыс. н. э. Дан обзор могильников и погребальных комплексов кулайской культуры в Сургутском Приобье и прилегающих регионах. Показаны разнообразие погребального обряда, его вероятная связь с социальной структурой общества. Оригинальность Барсовского VII могильника выражается в наличии погребений в лодках, а также в большом количестве культовых предметов. Высказано предположение, что здесь могли хоронить служителей культа (шаманов).
FİBROMYALJİ SENDROMUNDA KİNEZYOFOBİ: OBEZİTE, AĞRI ŞİDDETİ, YÜKSEK HASTALIK AKTİVİTESİ İLİŞKİSİ
Authors: AYDOGAN BAYKARA Rabia
Published: April 2022

Amaç: Fibromiyalji sendromunda hastalık şiddeti ile kinezyofobi arasındaki ilişkinin araştırılması amaçlandı.Gereç ve Yöntemler: Prospektif, kesitsel, vaka kontrol araştırması olarak planlanan bu çalışmaya Amerikan Romatoloji Koleji 2010 kriterlerine göre Fibromiyalji sendromu tanısı almış 21-67 yaş arası 149 hasta ile benzer özellikte 92 sağlıklı kontrol dâhil edildi. Hastalık şiddeti için Fibromiyalji Etki Anketi, ağrı şiddeti için vizüel analog skala, kinezyofobi için Tampa Kinezyofobi Ölçeği kullanıldı. Hastaların yaş, cinsiyet, vücut kitle indeksi gibi demografik verileri kaydedildi.Bulgular: Hasta grubu ve sağlıklı kontrol grubu arasında demografik veriler benzerdi. Tampa Kinezyofobi Ölçeği, hasta grubunda ortalama 41.51 (SS:7.31), kontrol grubunda ortalama 35.71 (SS:8.98) olarak bulunmuş olup anlamlı fark vardı (p<0.01. Hastalık şiddeti ile kinezyofobi arasında anlamlı korelasyon mevcuttu (p<0.01). Vizüel analog skala, Fibromiyalji Etki Anketi değerleri ise hasta grubunda kontrol grubuna göre anlamlı farklıydı (p<0.01). Vücut kitle indeksinin düşük (25 kg/m2 ve altı) ve yüksek grupları (25 kg/m2 üstü) ile kinezyofobi arasında anlamlı ilişki yoktu.Sonuç: Fibromiyalji sendromunda hastalık şiddeti arttıkça kinezyofobi de artmaktadır. Bu nedenle fibromiyalji sendromlu hastalarda tedavi planlarken kinezyofobi akılda tutulmalıdır.
SALGIN KAYGISI ÜZERİNDE PSİKOLOJİK SAĞLAMLIK VE MİZACIN ETKİSİNİN DEĞERLENDİRİLMESİ
Authors: KOCAKAYA Hanife , HARMANCI Hatice
Published: April 2022

Amaç: Bu çalışmada Covid-19 pandemisi döneminde yüz yüze eğitim görmekte olan tıp fakültesi 4., 5. ve 6. sınıf öğrencilerinin mizaç ve psikolojik sağlamlıklarının değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Bu araştırma kesitsel tipte ve tanımlayıcı bir çalışmadır. Araştırmaya gönüllülük ilkesiyle, çevrimiçi anket formunu dolduran 250 Tıp Fakültesi öğrencisi dahil edilmiştir. Tüm katılımcılara; sosyodemografik veri formu, TEMPS-A Mizaç Ölçeği (Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionaire), Salgın Hastalık Kaygısı Ölçeği ve Kısa Psikolojik Sağlamlık Ölçeği uygulanmıştır.Bulgular: Yaş ortalaması 23.12±1.76/yıl olan katılımcıların %60.4’ü kadın ve %39.6’sı erkeklerden oluşmaktadır. Katılımcıların psikolojik sağlamlık ölçeği puan ortalaması 17.91±2.48, salgın hastalık kaygısı ölçeği puan ortalaması 43.88±12.87’dir. Mizaç değerlendirmesi puan ortalaması depresif mizaç için 10.94±4.0, siklotimik mizaç için 9.42±5.04, hipertimik mizaç için 11.65±4.6, irritabl mizaç için 13.35±3.84 ve anksiyöz mizaç için 14.90±6.19 olduğu tespit edilmiştir. Araştırmada kadınların salgın hastalık kaygısı puan ortalamalarının, erkeklere göre anlamlı düzeyde yüksek olduğu tespit edilmiştir (F=0.120, t=4.082, p=0.000). Psikolojik sağlamlıkla salgın kaygısı ve anksiyöz mizaç arasında anlamlı negatif yönlü bir ilişkinin (r=-0.289, r=-0.457) olduğu tespit edilmiştir. Anksiyöz mizaç ile salgın kaygısı toplam puanı arasında güçlü pozitif ilişki (r=0.408) bulunmuştur.Sonuç: Çalışmamızda, cinsiyetin salgın kaygısı üzerinde anlamlı düzeyde yordayıcı olduğu, psikolojik sağlamlık ile salgın kaygısı ve anksiyöz mizaca sahip olma arasında negatif yönlü bir ilişki olduğu bulunmuştur.
AKUT GASTROENTERİTLİ ÇOCUKLARDAKİ ADENOVİRÜS VE ROTAVİRÜS SIKLIĞININ VE MEVSİMSEL DAĞILIMININ ARAŞTIRILMASI
Authors: TOKAK Semih , UĞURCAN Doğaç , ATILGAN GÜZEŞ Eylem
Published: April 2022

Amaç: Adenovirüs ve rotavirüs kaynaklı gastroenteritler gelişmiş ve gelişmekte olan ülkelerdeki bebeklerde ve çocuklarda morbidite ve mortalitenin önemli bir nedenidir. Bu çalışmada hastanemizin çocuk polikliniklerinde akut gastroenterit ön tanısı alan hastalarda adenovirüs ve rotavirüs sıklığının belirlenmesi ve viral etkenlerin yaş, cinsiyet ve mevsimsel dağılımının değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Bu çalışmada, Ocak 2016-Aralık 2021 yılları arasında hastanemizde akut gastroenterit ön tanısı alan 3927’si erkek, 3110’u kız toplam 7037 hastanın sonuçları retrospektif olarak incelendi. Hastaların dışkı örneklerindeki adenovirüs ve rotavirüs antijenlerini tespit etmek için kalitatif immunokromatografik test kullanıldı.Bulgular: Çalışmaya dahil edilen 7037 hastadan 988’inde (%14.04) viral antijen saptandı. Rotavirüs 750 (%10.7) hastada, adenovirüs ise 238 (%3.3) hastada saptandı. Adenovirüs ve rotavirüs antijenleri en sık 1-2 ve 3-5 yaş grubunda görüldü. Adenovirüs ve rotavirüs antijen pozitifliği açısından yaş grupları arasında istatistiksel olarak anlamlı bir fark mevcuttu (p<0.05). Rotavirüs pozitifliği kız hastalarda %11.7, erkek hastalarda %9.8 olarak gözlemlendi. Bu fark istatistiksel olarak anlamlı bulundu (p<0.05). Adenovirüs ve rotavirüs antijenlerinin her ikisinin de pozitif olduğu hastaya rastlanılmadı. Viral etkenlerin mevsimsel dağılımına göre, rotavirüs en sık kış ve ilkbahar mevsimlerinde, adenovirüs ise en sık sonbahar mevsiminde tespit edildi.Sonuç: Çalışmamızda, çocukluk çağındaki akut gastroenteritlerde adenovirüs ve rotavirüslerin önemli etkenler olduğu görülmüştür. Hastalarda akut gastroenterite neden olan viral etkenlerin saptanması, erken tanı ve semptomatik tedavi olanağı sağlayacak olup gereksiz antibiyotik kullanılmasını da önleyecektir. Ayrıca rotavirüsün neden olduğu gastroenteritleri azaltmak için rutin aşı takvimine bu viral etkenin aşısını dahil etme seçeneği de değerlendirilmelidir.
PROGNOSTIC FACTORS IN DEEP NECK INFECTION
Authors: CÖMERT Ela , ŞİMŞEK Buğra
Published: April 2022

Objective: The present study aimed to evaluate the prognostic importance of hematologic test findings in addition to the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic inflammation response index, and C-reactive protein in the patients with deep neck infection and to compare these results with healthy subjects.Material and Methods: The study included 32 patients diagnosed as deep neck infection and treated by surgical intervention and parenteral antibiotics. As none of the patients had life-threatening complications, the prognosis was determined by the length of stay in the hospital. The effect of age, sex, pre-treatment blood parameters, abscess culture results, and medical comorbidities on prognosis were analysed. Pre- and post-treatment blood parameters were compared in each patient. Blood parameters were also compared between healthy subjects and patients.Results: When comparing patients with length of stay in the hospital ≤7 days and >7 days, significant differences were observed for age (t=-2.568, p=0.015) and red blood cell distribution width values obtained preoperatively (Z=-2.343, p=0.019). The correlation analysis revealed a positive correlation between age and length of stay in the hospital. (r=0.450, p=0.010), and between length of stay in the hospital and comorbidity (r=0.366, p=0.039). Logistic Regression analysis revealed that age could be the best marker in the prediction of the patients with worse prognosis (percentage of predicting patients with worse prognosis=73.3%, B=0.054, Wald=4.967, p=0.026).Conclusion: The present study confirmed that the prognosis was worse in older patients and patients with comorbid disease whereas no relation was observed between the inflammatory markers and prognosis.
HYPERCALCEMIA DUE TO PRIMARY HYPERPARATHYROIDISM IN A PATIENT WITH GRAVES' DISEASE
Authors: KALAN SARI Işılay , COŞAR Ramazan , ARIKAN DURMAZ Şenay
Published: April 2022

Hyperthyroidism is a hypermetabolic condition associated with excessive production of thyroid hormones by the thyroid gland. Thyroid hormones play an important role in bone and calcium metabolism. Mild to moderate hypercalcemia due to hyperthyroidism has been reported in approximately one in five patients. Hypercalcemia due to hyperthyroidism is associated with decreased or subnormal parathyroid hormone levels. The co-occurrence of hyperthyroidism and primary hyperparathyroidism is rare. However, in patients with hyperthyroidism, it is necessary to evaluate the parathyroid glands if hypercalcemia persists after an euthyroid state is reached.Here, we report the case of a 30-year-old man with hypercalcemia who had Graves' disease and primary hyperparathyroidism and was successfully treated with combined thyroid and parathyroid surgery.