bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitochondrial dysfunction is an early consequence of partial or complete dystrophin loss in mdx mice.
Authors: Moore Timothy M , Lin Amanda , Strumwasser Alexander R , Cory Kevin , Whitney Kate , Ho Theodore , Ho Timothy , Lee Joseph L , Rucker Daniel H , Nguyen Christina Q , Yackly Aidan , Mahata Sushil K , Wanagat Jonathan , Stiles Linsey , Turcotte Lorraine P , Crosbie Rachelle H , Zhou Zhenqi
Published: February 2020

Background:Muscular dystrophies are a diverse family of genetic and hereditary disorders manifested primarily by the progressive wasting of skeletal muscle. Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, has no cure, with most treatments seeking to mitigate symptoms. Emerging gene or stem cell therapies hold promise, although widespread clinical adoption may not occur for quite some time. There remains a need for alternative strategies, including drug and lifestyle combination-based therapies, and to continue furthering understanding the physiological effects of dystrophin gene mutations. Mitochondrial dysfunction is well known as a pathological feature of DMD. However, whether mitochondrial dysfunction is a cause or the consequence of DMD is not well known. We hypothesized that dystrophin deletion would lead to mitochondrial and metabolic abnormalities prior to the onset of observable muscle damage.Methods:Utilizing the commonly employed muscular dystrophy mouse model, C57BL/10ScSn-Dmdmdx/J (mdx), we sought to determine how the loss of dystrophin effects mitochondria and metabolism in both male and female mdx mice. We also treated male mdx mice with an autophagy inhibitor, leupeptin, to investigate its potentially impact on mdx pathology.Results:We detected, via electron microscopy, aberrant mitochondrial morphology, reduced cristae numbers per area of mitochondria, and large mitochondrial vacuoles from both two-week-old male and 24-week-old female mdx carrier mice, prior to the onset of visible muscle fiber damage. We systematically characterized mitochondria during disease progression starting before the onset of gross muscle fiber damage noting changes in mitochondrial DNA copy number and regulators of mitochondrial size. We further detected mild metabolic and mitochondrial impairments in female mdx carrier mice (heterozygous mdx/+) that was exacerbated with high-fat diet feeding. Lastly, we found autophagy inhibition did not improve pathology in mdx male mice.Conclusions:Our results suggest that prior to the onset of visible muscle damage, mitochondrial and metabolic abnormalities are present within the mdx mouse.
Well-managed gestational diabetes mellitus is no longer a risk factor for neonatal RDS — a case-control study
Authors: Xi Guannan , Ying Qian , Wang Xuefeng , Luo Fei , Lu Chengqiu , Yang Yun , Wang Jimei
Published: February 2020

BACKGROUND Diabetes in pregnancy used to be considered associated with a higher risk of respiratory distress syndrome(RDS) in neonates. However, whether well-managed gestational diabetes remains an independent risk factor is unclear. This study was to determine the associations of them.METHOD This was a case-control study conducted at the Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China. We collected data from 101 RDS infants and 101 RDS infants from among 1749 infants, through a standardized protocol with predefined inclusion and exclusion criteria. Two investigators enrolled in recording same datas twice to minimize bias. Assessment of diabetes management was based on HbA1c and random blood glucose measurements. Univariable and multivariable logistic regression was performed to calculate the odds ratio (OR). An intergroup analysis was conducted between RDS infants and those without RDS, and a subgroup analysis was conducted between RDS neonates born to women with gestational diabetes and those born to women without gestational diabetes.RESULTS The mean (±SD) gestational age of the RDS infants was 35.9 (±1.9) weeks, which was similar to that of the non-RDS infants (35.7±1.3)weeks). The HbA1c levels at diabetes diagnosed, the HbA1c levels right before delivery and the RBG levels before delivery had no significant differences, and all of them were below a well-controlled level. In the intergroup analysis, the morbidity of gestational diabetes between the two groups showed no significant differences in the adjusted analyses (adjusted OR 1.40, 95% CI 0.59-3.36). However, the case group had significantly more placental abnormalities (adjusted OR 3.61, 95% CI 1.63-8.00), fetal distress (adjusted OR 4.20, 95% CI 1.87-9.46), and asphyxia (adjusted OR 3.74, 95% CI 1.59-8.81) than the control group. In the subgroup analysis, the total dose of the PS applications, incidence of complications, and need for respiratory support (total and separate) were not significantly different between the two groups.CONCLUSIONS Well managed gestational diabetes is no longer a significant risk factor for RDS, while acute or chronic ischemia factors are. Diet and exercise are sufficient for the GDM management target of HbA1c below 6.5%.
Dietary inflammatory index is associated with lipid profile and interleukin-6 in postmenopausal women: A cross-sectional study
Authors: Aslani Zahra , Siassi Fereydoun , Qorbani Mostafa , Shivappa Nitin , Hébert James R , Koohdani Fariba , Hedayati Mehdi , Abshirini Maryam , Soleymani Mahshid , Sotoudeh Gity
Published: February 2020

Background: The prevalence of diseases associated with chronic inflammation is higher in postmenopausal women. The dietary inflammatory index (DII®) was developed to evaluate the diet-associated inflammation. The aim of this study was to evaluate the association between the DII score and levels of fasting blood sugar (FBS), lipid profile, and inflammatory biomarkers.Methods: This cross-sectional study was conducted on 175 postmenopausal women referred to the southern health centers and health clinics affiliated to the southern municipality of Tehran, Iran. The DII score was calculated using dietary intakes derived from a validated food frequency questionnaire (FFQ). Concentrations of FBS, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were determined. Using linear regression models, we evaluated the association between the DII score and blood biomarkers. Results: After adjustment for covariates, the highest DII score category was associated with higher TG value (bDIIt3vs1= 0.08, p=0.03), TG/HDL-C ratio (bDIIt3vs1= 0.10, p=0.04), and IL-6 concentration (bDIIt3vs1= 0.06, p=0.01) compared to the first category of the DII score. Conclusions: We found a positive association between pro-inflammatory diet and unfavorable biomarkers in postmenopausal women.
Synthetic Strategies and Biological Potential of Coumarin-Chalcone Hybrids: A New Dimension to Drug Design
Authors: Pasricha Sharda , Gahlot Pragya
Published: February 2020

Privileged scaffolds are ubiquitous as effective templates in drug discovery regime. Natural and synthetically derived hybrid molecules are one such attractive scaffold for therapeutic agent development due to their dual or multiple modes of action, minimum or no side effects, favourable pharmacokinetics and other advantages. Coumarins and chalcone are two important classes of natural products affording diverse pharmacological activities which make them ideal templates for building coumarin-chalcone hybrids as effective biological scaffold for drug discovery research. Provoked by the promising medicinal application of hybrid molecules as well as those of coumarins and chalcones, the medicinal chemists have used molecular hybridisation strategy to report dozens of coumarin- chalcone hybrids with a wide spectrum of biological properties including anticancer, antimicrobial, antimalarial, antioxidant, anti-tubercular and so on. The present review provides a systematic summary on synthetic strategies, biological or chemical potential, SAR studies, some mechanisms of action and some plausible molecular targets of synthetic coumarin-chalcone hybrids published from 2001 till date. The review is expected to assist medicinal chemists in the effective and successful development of coumarin- chalcone hybrid based drug discovery regime.
Positive Predictive Value Surfaces as a Complementary Tool to Assess the Performance of Virtual Screening Methods
Authors: Morales Juan F. , Chuguransky Sara , Alberca Lucas N. , Alice Juan I. , Goicoechea Sofía , Ruiz María E. , Bellera Carolina L. , Talevi Alan
Published: February 2020

Background:

Since their introduction in the virtual screening field, Receiver Operating Characteristic (ROC) curve-derived metrics have been widely used for benchmarking of computational methods and algorithms intended for virtual screening applications. Whereas in classification problems, the ratio between sensitivity and specificity for a given score value is very informative, a practical concern in virtual screening campaigns is to predict the actual probability that a predicted hit will prove truly active when submitted to experimental testing (in other words, the Positive Predictive Value - PPV). Estimation of such probability is however, obstructed due to its dependency on the yield of actives of the screened library, which cannot be known a priori.

Objective:

To explore the use of PPV surfaces derived from simulated ranking experiments (retrospective virtual screening) as a complementary tool to ROC curves, for both benchmarking and optimization of score cutoff values.

Methods:

The utility of the proposed approach is assessed in retrospective virtual screening experiments with four datasets used to infer QSAR classifiers: inhibitors of Trypanosoma cruzi trypanothione synthetase; inhibitors of Trypanosoma brucei N-myristoyltransferase; inhibitors of GABA transaminase and anticonvulsant activity in the 6 Hz seizure model.

Results:

Besides illustrating the utility of PPV surfaces to compare the performance of machine learning models for virtual screening applications and to select an adequate score threshold, our results also suggest that ensemble learning provides models with better predictivity and more robust behavior.

Conclusion:

PPV surfaces are valuable tools to assess virtual screening tools and choose score thresholds to be applied in prospective in silico screens. Ensemble learning approaches seem to consistently lead to improved predictivity and robustness.
A Review on Impact of Medicinal Plants on the Treatment of Oral and Dental Diseases
Authors: Arumugam Balakrishnan , Subramaniam Arunambiga , Alagaraj Praveena
Published: February 2020

:

Plants play a vital role in the general wellbeing of an individual. Globally plants are habitually
used by the people for the treatment and prevention of various ailments. There is an increased
attempt made from ancient days to prevent the disease occurrence rather than to treat it. Through the
development of modern scientific procedures, it is now identified that the usage of plants in different
forms promotes the health of the patient. Oral and dental hygiene is the primary factor of a human
being to lead a healthy life. Poor diet, nutrition and improper hygienic practices lead to teeth and gum
diseases, dental cavities and plaque etc., Use of herbal extracts and their products in day-to-day life is
a promising and interesting alternative to synthetic compounds to control oral diseases. The present
review summarizes the usage of medicinal plants in the treatment and prevention of oral and dental
diseases in different aspects.
Causes of Deaths in Northern Cyprus: Implications for Accurate Recording and Prevention of Deaths
Authors: Artac Ozdal Macide , Behlul Seda
Published: February 2020

Background:

Reporting the causes of deaths completely and correctly is important to develop interventions for reducing death rates in populations.

Objective:

This study aimed to evaluate the death rates, major causes of deaths and accuracy of recording of death causes in Northern Cyprus between 2007 and 2016.

Methods:

Data on death rates and causes of deaths between 2007 and 2016 were collected. The data were analyzed using SPSS 23 vs to determine the trends in death rates and to evaluate the ranking of causes of deaths.

Results:

There was an overall decrease in crude death rates between 2007 and 2016. The proportion of deaths in Northern Cyprus varied in terms of gender and age between 2007 and 2016, with death rates greater in males compared to females (1.89 times greater in 2007) and with higher death rates in people of older ages compared to younger people. The most common cause of death was ischemic heart diseases in all years, except in 2008, where senility was reported as the most common cause of death.

Conclusion:

There were decreasing trends in mortality rates in Northern Cyprus, with ischemic heart diseases reported as the top cause of deaths in the population. Accurate and complete reporting must be ensured for effective health policies and reduction of health expenditures.
Prevalence and Potential Risk Factors Associated with High Sodium : Intake among Chinese-Haw Tribal in the Rural Area of Chiang Rai Province, Northern Thailand
Authors: Winyangkul Phatcharin , Thaikruea Lakkana , Siviroj Penprapa , Pruenglampoo Sakda
Published: February 2020

Background:

Sodium intake has a known association with increasing hypertension, cause of death from Cardiovascular Diseases (CVDs) worldwide. Ethnic group is increasingly exposed to risk factors to CVD causing of the urbanization and cultural changes.

Methods:

This cross-sectional study aimed to investigate the prevalence and potential factors associated with high sodium intake in the Chinese-Haw tribe in Chiang Rai province. Stratified random sampling was used to recruit participants. Face-to-face interviews were used for demographic data and assessment of dietary sodium knowledge, self-efficacy and food consumption. For dietary sodium intake, first-morning urine were collected for identifying concentration of sodium in millimoles per litre (mmol/L) using Atomic Absorption Spectrophotometer. Unconditional multiple logistic regression was used for determining risk factors associated with high sodium intake.

Results:

There were 302 participants of which majority were women (71.9%), with average age of 49.50 years (±12.12 S.D.). The prevalence of sodium intake was 90.70% more than 2,000 mg/day (High). The association between potential risk factors and high sodium intake revealed that men had higher risk than women (Risk Ratio 1.13, 95%CI 1.07 - 1.19). Multivariate analysis revealed only gender can predict a high sodium intake after adjusted for smoking patterns and alcohol consumption (adjusted odds ratio 13.73, CI 1.43 - 131.95).

Conclusion:

Prevalence of excess sodium intake per day in the Chinese-Haw tribe was high. This might lead to unhealthy effects. The population at risk should receive appropriate intervention urgently.
Особенности разрушения ударников из пористого сплава на основе вольфрама с упрочняющим наполнителем при взаимодействии с бронепреградами
Authors: Ищенко А.Н. , Афанасьева С.А. , Белов Н.Н. , Буркин В.В. , Галсанов С.В. , Касимов В.З. , Кудрявцев В.А. , Липатникова Я.Д. , Марцунова Л.С. , Рогаев К.С. , Саммель А.Ю. , Скосырский А.Б. , Югов Н.Т.
Published: February 2020

In this work, computational and experimental studies of the process of destruction of composite firing pin of porous alloy tungsten+nickel+iron+cobalt with 10 % content of titanium tungsten carbide at high-speed collision with steel barriers. It is shown that at ballistic tests with the broad range of speeds, significant exceeding of penetration of these firing pins in steel barriers in comparison with a mass-dimensional analog of the W-Ni-Fe-90 alloy. Based on the analysis of the crater morphology and structure of the striker fragments after penetration into the barrier, the assumption of implementation of the self-sharpenings mode of the firing pin, by means of localization of plastic deformation is made that leads to decrease in the effective area of interaction and increase in depth of penetration. Modification of a mathematical model of a porous ideal elasto-plastic solid with complex structure for the description of destruction with a possibility of accounting of the adiabatic shift mechanism in the course of interaction of the firing pin and a barrier is carried out.
Вращение плазменной струи высокочастотными электромагнитными полями и ее использование для масс-сепарации
Authors: Горшунов Н.М. , Потанин Е.П.
Published: February 2020

Equations are obtained that describe the characteristics of the azimuthal motion and radial expansion of a plasma jet under the action of a rotating transverse magnetic field of a dipole configuration in a longitudinal static magnetic field. The analysis was carried out both in the multicomponent approximation and on the basis of MHD equations taking into account the Hall effect. Based on the obtained dependences of the azimuthal and radial ion velocities on the magnetic field values, the separation characteristics of the direct-flow plasma centrifuge are estimated for the separation of a two-component binary mixture simulating spent nuclear fuel. It was shown that the concentration of the heavy uranium-plutonium component in the product flow can be increased from the initial 96 to 99.8% with a fuel component extraction of 0.87.
Исследование кинетических параметров схемы лазерной фотоионизации лютеция
Authors: Дьячков А.Б. , Горкунов А.А. , Лабозин А.В. , Миронов С.М. , Панченко В.Я. , Фирсов В.А. , Цветков Г.О.
Published: February 2020

Разработка лазерного фотоионизационного метода получения радионуклида 177Lu для применения в медицине требует знания интенсивностей светового насыщения по каждой ступени схемы фотоионизации лютеция (5d6s2 2D3/2-5d6s6p 4Fo5/2-5d6s7s 4D3/2-(53375 сm-1)o1/2) с учетом используемых компонент сверхтонкой структуры переходов. В работе экспериментально определены эффективные сечения возбуждения различных сверхтонких компонент переходов для изотопов 175Lu, 176Lu, 177Lu и 177mLu излучением импульсных перестраиваемых по длине волны лазеров на красителях, накачиваемых лазерами на парах меди. Ключевые слова: лазерная фотоионизация, сверхтонкая структура, 177Lu, лазерное разделение изотопов.
Зажигание каменных углей различных стадий метаморфизма лазерными импульсами в режиме свободной генерации
Authors: Адуев Б.П. , Нурмухаметов Д.Р. , Крафт Я.В. , Исмагилов З.P.
Published: February 2020

A study was made of laser ignition (1064 nm, 120 μs) of coals of grades DG, G, G, and K. For all grades of coal, three successive ignition stages were found, characterized by threshold radiation energy densities that have characteristic values for each grade of coal.
Comparative Analysis of Paper-Based and Web-Based Versions of the National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy-Breast Cancer Symptom Index (NFBSI-16) Questionnaire in Breast Cancer Patients: Randomized Crossover Study (Preprint)
Authors: Ma Jinfei , Zou Zihao , Pazo Emmanuel Eric , Moutari Salissou , Liu Ye , Jin Feng
Published: February 2020

BACKGROUND

Breast cancer remains the most common neoplasm diagnosed among women in China and globally. Health-related questionnaire assessments in research and clinical oncology settings have gained prominence. The National Comprehensive Cancer Network–Functional Assessment of Cancer Therapy–Breast Cancer Symptom Index (NFBSI-16) is a rapid and powerful tool to help evaluate disease- or treatment-related symptoms, both physical and emotional, in patients with breast cancer for clinical and research purposes. Prevalence of individual smartphones provides a potential web-based approach to administrating the questionnaire; however, the reliability of the NFBSI-16 in electronic format has not been assessed.

OBJECTIVE

This study aimed to assess the reliability of a web-based NFBSI-16 questionnaire in breast cancer patients undergoing systematic treatment with a prospective open-label randomized crossover study design.

METHODS

We recruited random patients with breast cancer under systematic treatment from the central hospital registry to complete both paper- and web-based versions of the questionnaires. Both versions of the questionnaires were self-assessed. Patients were randomly assigned to group A (paper-based first and web-based second) or group B (web-based first and paper-based second). A total of 354 patients were included in the analysis (group A: n=177, group B: n=177). Descriptive sociodemographic characteristics, reliability and agreement rates for single items, subscales, and total score were analyzed using the Wilcoxon test. The Lin concordance correlation coefficient (CCC) and Spearman and Kendall τ rank correlations were used to assess test-retest reliability.

RESULTS

Test-retest reliability measured with CCCs was 0.94 for the total NFBSI-16 score. Significant correlations (Spearman ρ) were documented for all 4 subscales—Disease-Related Symptoms Subscale–Physical (ρ=0.93), Disease-Related Symptoms Subscale–Emotional (ρ=0.85), Treatment Side Effects Subscale (ρ=0.95), and Function and Well-Being Subscale (ρ=0.91)—and total NFBSI-16 score (ρ=0.94). Mean differences of the test and retest were all close to zero (≤0.06). The parallel test-retest reliability of subscales with the Wilcoxon test comparing individual items found GP3 (item 5) to be significantly different (P=.02). A majority of the participants in this study (255/354, 72.0%) preferred the web-based over the paper-based version.

CONCLUSIONS

The web-based version of the NFBSI-16 questionnaire is an excellent tool for monitoring individual breast cancer patients under treatment, with the majority of participants preferring it over the paper-based version.
The Semantic Space in the Novel of A. Nikolaenko “To kill Bobrykin. The History of one Murder”
Authors: Strelnikova Nataliia D.
Published: February 2020

In the article the novel “To kill Bobrykin. The history of one murder” by A. Nikolaenko, the 2017 “Russian Buker” prize-winner, is considered as heterogeneous text. The text, semeiotically complicated, is being analyzed through the prism of cultural codes. Different definitions for the concept “cultural code” are given. The semantic space of the novel is various. Iconic works of XX century, to which the author is drawn by the author, -literary texts and screen texts, - are considered as cultural codes. This approach of looking allows to read Nikolaenko novel on other semeiotic level: to trace numerous references, including implicit - to symbolist novel of The Silver Age. In the focus of attention - the interaction and intersection of symbols and meanings.
Irony as a Cultural and Language Phenomenon
Authors: Gornostaeva Anna A.
Published: February 2020

The article focuses on irony as a multilateral phenomenon, which is the subject of many spheres: history, philosophy, culture, literature, linguistics etc. Different views on irony’s production and interpretation, as well as its development in history, are analyzed. Irony is viewed as a historic and cultural phenomenon, as well as a linguistic one. Irony exists in the sphere of other phenomena - humour, satire, sarcasm, joke etc. These notions are interrelated, they have something in common, yet irony has its own characteristics and peculiarities. It is stated that irony and language are inseparable, irony can function as an utterance, as a speech act and as a speech genre. The aim of the article is to analyze the characteristics of irony in discourse and to determine the conditions of efficient ironic communication. The author argues that irony as a discourse category is a common product of both the speaker and the recipient. Thus, to be effective, an ironic speech act needs proper cultural, social and psychological atmosphere. Theoretical basis is represented by both classical works on the nature of the comic, and contemporary research on irony.
PERJANJIAN DAN JAMINAN FIDUSIA
Authors: Khairina Nazla , Bustamam Kamaruzaman
Published: February 2020

Perjanjian fidusia adalah perjanjian hutang piutang kreditor kepada debitor yang melibatkan penjaminan. Jaminan tersebut kedudukannya masih dalam penguasaan pemilik jaminan. Tetapi untuk menjamin kepastian hukum bagi kreditor maka dibuat akta yang dibuat oleh notaris dan didaftarkan ke kantor pendaftaran fidusia. Terdapat sekurangnya dua orang” menunjukkan pada kita semua bahwa suatu perjanjian tidak mungkin dibuat sendiri. Dengan demikian setiap tindakan yang dilakukan oleh orang perorangan untuk kepentingannya sendiri, tidaklah termasuk dalam kategori perjanjian. Pernyataan selanjutnya yang menyatakan bahwa “perbuatan tersebut melahirkan perikatan di antara pihak-pihak yang berjanji tersebut. Pelepasan hak atas jaminan fidusia oleh penerima fidusia mengakibatkan hapusnya jaminan fidusia, hal ini dapat terjadi karena semata-mata tergantung kepada pihak penerima fidusia. Biasanya pelepasan tersebut menjurus kepada alasan subjektif pemegang fidusia, misalnya debitur dalam membayar utang selalu tepat waktu, dan beriktikad baik untuk menghindari wanprestasi.
Mekanisme Penyimpanan Dan Pemusnahan Benda Sitaan Narkotika (Studi Kasus Pada Kejaksaan Tinggi Aceh)
Authors: Mawar Sitti , Rizal Safrul
Published: February 2020

Kejaksaan Tinggi Aceh merupakan Instansi Negara yang memiliki kewenangan dalam hal melakukan penyimpanan serta pemusnahan Benda Sitaan Narkotika. Secara aturan perundang-undangan, penyimpanan Benda Sitaan Narkotika semestinya disimpan di Rumah Penyimpanan Benda Sitaan Negara (Rupbasan) sebagaimana ketentuan pasal 44 KUHAP, dan pemusnahan terhadap Benda Sitaan Narkotika dilaksanakan paling lama dalam jangka waktu 7 (tujuh) hari setelah  memperoleh utusan pengadilan yang memiliki kekuatan hukum tetap sebagaimana ketentuan dalam Undang-Undang nomor 35 tahun 2009 tentang Narkotika. Namun faktanya aturan perundang-undangan tersebut tidak dijalankan dengan semestinya. Penyimpanan Benda Sitaan Narkotika tidak sepenuhnya disimpan di Rupbasan melainkan disimpan di Kejaksaan Negeri Banda Aceh, serta pemusnahan Benda Sitaan Narkotika yang telah memperoleh putusan pengadilan tidak langsung dimusnahkan dalam jangka waktu 7 (hari) setelah putusan pengadilan tersebut dikeluarkan. Penelitian ini bertujuan menjawab permasalahan: Pertama, bagaimana mekanisme penyimpanan dan pemusnahan Benda Sitaan Narkotika yang dilakukan oleh Kejaksaan Tinggi Aceh ; Kedua, pa saja kendala yang dihadapi dalam melakukan penyimpanan dan pemusnahan Benda Sitaan Narkotika serta upaya yang dilakukan dalam mengatasi kendala tersebut. Penelitian dilakukan menggunakan metode penelitian Yuridis Empiris. Hasil penelitian menunjukkan bahwa Mekanisme Penyimpanan dan Pemusnahan Benda Sitaan Sarkotika yang dilakukan oleh kejaksaan tidak sesuai dengan peraturan perundang-undangan dikarenakan kendala-kendala yang dihadapi seperti kendala Letak Rumah Penyimpanan Benda Sitaan Negara tidak strategis, tempat penyimpanan yang kurang memadai, anggaran yang terbatas, prosedur pemusnahan yang rumit. Namun pihak Kejaksaan Tinggi Aceh telah berupaya mengatasi kendala tersebut dengan melakukan koordinasi dengan Kejaksaan Negeri Banda Aceh, mengajukan anggaran tambahan, mengefaluasi kendala dan hambatan yang dihadapi di lapangan.
A Ergologia como aporte teórico-metodológico para análise coletiva do trabalho do Bibliotecário
Authors: Campos Ana Claudia Borges , Rosemberg Dulcinea Sarmento
Published: February 2020

Apresenta a Ergologia como aporte teórico-metodológico, idealizada por Yves Schwartz, para viabilizar a análise coletiva do trabalho do bibliotecário a partir de uma pesquisa que teve como objetivo principal colocar em análise a atividade de gestão de informação por bibliotecários-gestores. Discorre sobre a Ergologia como abordagem teórica potente para a análise coletiva do trabalho dispensando a hierarquização de saberes entre trabalhadores e pesquisadores. Ressalta o método ergológico como relevante dispositivo para disparar a análise das atividades laborais pelos próprios trabalhadores. Socializa o método ergológico que propiciou o processo dialógico equânime entre bibliotecários, alunos e docentes de Biblioteconomia sobre a atividade de gestão da informação. Conclui‐se que a utilização do referido método para análise do trabalho instiga os trabalhadores a uma reflexividade sobre o seu trabalho, o que resulta na ampliação do poder de agir, no caso, dos bibliotecários que, historicamente, vêm sendo convocados a colocarem em questão: o que fazem? Como fazem? Por que fazem? Para que fazem?
Direito de Acesso à Informação: uma análise a partir das realidades espanhola e brasileira
Authors: Santos João Carlos Gardini , Fernández Molina Juan Carlos , Guimarães José Augusto Chaves
Published: February 2020

A questão do acesso à informação vem impactando significativamente a Ciência da Informação, na atualidade, em especial nos arquivos, como forma de garantia da cidadania. No caso do Brasil e da Espanha, países com larga tradição de colaboração e diálogo no campo da Ciência da Informação, tem-se, em ambos, sistemas jurídicos com leis que garantem o direito de acesso à informação pública, ainda que se verifiquem divergências quanto a sua natureza jurídica. Desse modo, identificou-se a necessidade de uma análise comparativa de como a questão do acesso à informação vem ocorrendo em ambos os países. Sendo assim, objetivou-se identificar e analisar como a questão do acesso à informação é tratada nos atuais contextos espanhol e brasileiro, nos âmbitos legislativo e doutrinário. Por meio da identificação de dez categorias mínimas e essenciais às leis de acesso à informação pública, realizou-se uma pesquisa documental de caráter exploratório, tendo sido possível constatar a presença das mesmas nas dimensões legislativas espanhola e brasileira, utilizando-se, de forma adaptada, da metodologia de análise de conteúdo.
Novas tecnologias, a busca e o uso de informação no ensino médio
Authors: Nascimento Anderson Messias Roriso do , Gasque Kelley Cristine Gonçalves Dias
Published: February 2020

O artigo resulta de pesquisa de doutorado sobre como os jovens do ensino médio buscam e usam a informação por meio das novas tecnologias para a formação escolar. A pesquisa é de natureza qualitativa, com a realização de grupos de discussões em três escolas privadas do ensino médio, sendo uma de formação profissional e tecnológica do Distrito Federal. O método documentário fundamentou a análise dos grupos de discussão. Os resultados mostram que os estudantes percebem o ensino médio como “treinamento” para o vestibular. As escolas não desenvolvem estratégias para o ensino de busca e uso da informação. Os estudantes usam o google, por considerarem a forma mais rápida de acessar a informação. Estudam de forma tradicional, com resumos e leituras, mas agregam alguns recursos da internet como videoaulas. Preferem usar material impresso para reduzir o risco de desatenção. Não usam a biblioteca escolar e relatam distanciamento entre a biblioteca escolar e a prática docente. Por fim, o artigo apresenta diretrizes para melhorar a busca e o uso da informação no espaço escolar.
A dinâmica da produção científica a partir da perspectiva das práticas informacionais
Authors: Prado Maíra , Araújo Carlos Alberto Ávila
Published: February 2020

Esse trabalho busca compreender as práticas informacionais dos pesquisadores, no que tange a obtenção de informação e as práticas de produção científica. Os resultados demonstra que além dos meios mais consolidados para obtenção e atualização da informação, os pesquisadores tem se atentado a novas formas de perceber informações que são relevantes para a sua pesquisa, assim como uma preocupação de apresentar novos pensadores para pautar as reflexões na pesquisa. No que se refere as práticas de publicação científica,  percebe-se que as agências reguladoras de pós-graduação influenciam a dinâmica de publicação, mas percebe-se que os pesquisadores também utilizam estratégias para conciliar essa demanda ao seu desejo pessoal.
Breve histórico da literatura infantil brasileira
Authors: D'Ávila Fernanda Martins , Caldin Clarice Fortkamp
Published: February 2020

Destacam-se quatro fases da literatura infantil no Brasil como reflexos da organização política, econômica e cultural de nosso país. A primeira fase, com as adaptações e traduções de obras europeias, com o intuito de importar o modo de vida, prática que gradativamente passa pela necessidade de identificar/forjar uma identidade e formas de valorização do estado nação, entrando assim no viés ideológico nacionalista e no patriotismo. A segunda fase, expressando uma ruptura de paradigmas trazida por Monteiro Lobato que reflete as mudanças culturais na sociedade. Uma terceira fase pautada em mais liberdade e novas experiências, impostas tanto pelas novas concepções da pedagogia e da educação, como pelas exigências da sociedade e incorporações das novas tecnologias. E a quarta fase que expressa a ruptura com a literatura infantil apenas como recurso pedagógico. A literatura infantil passa a ser vista, desde então, como algo lúdico, catártico e libertador, plena dos encantos da imagética, mas também preparando as crianças para o mundo em que a diversidade e a alteridade passam a fazer parte do cotidiano.
No Reverso da Mídia
Authors: Araújo Nascimento Robéria Nádia
Published: February 2020

Trata-se de uma análise contextual sobre o fenômeno da transexualidade, derivada de uma pesquisa em curso que considera os aportes teóricos de alteridade (BHABHA, 2005), identidade (HALL, 2004) e estigmas (GOFFMAN, 1988). O texto notabiliza as vozes de transexuais masculinos e femininos a partir de suas narrativas (MEDINA, 2003; ALVES, 2008), ao mesmo tempo em que produz uma reflexão sobre os tratamentos midiáticos concedidos à problemática.
Laerte Coutinho
Authors: Carvalho Michelly Santos de
Published: February 2020

O presente trabalho analisa a categoria performatividade de gênero, de Judith Butler, nas concepções apresentadas por Laerte Coutinho no documentário Laerte-se, exibido na provedora global de filmes e séries de televisão Netflix. Neste estudo, usamos a metodologia de análise temática para designar os temas que serão focados no documentário escolhido. Como resultado, observamos que Laerte Coutinho aprendeu o desempenho do gênero feminino. Os atos estão sendo constantemente estudados por ela. Quanto mais ela se aproxima dessa performance, mais se sente mulher. As questões sobre identidade e corpo nas concepções de Laerte nos levam à conclusão de que ela não teoriza quem será no futuro. Ela vive sua performance no momento presente e evita se encaixar em determinações e conceituações fechadas.
On k-type spacelike slant helices lying on lightlike surfaces
Authors: Öztürk Ufuk , Nesovic Emilija , Koç Öztürk
Published: February 2020

In this paper, we define k-type spacelike slant helices lying on a lightlike
surface in Minkowski space E31 according to their Darboux frame for k ? {0,1,2}. We obtain the necessary and the sufficient conditions for spacelike
curves with non-null and null principal normal lying on lightlike surface to
be the k-type spacelike slant helices in terms of their geodesic curvature,
normal curvature and geodesic torsion. Additionally, we determine their axes
and show that the Darboux frame of a spacelike curve lying on a lightlike
surface coincides with its Bishop frame if and only if it has zero geodesic
torsion. Finally, we give some examples.
Relative multifractal box-dimensions
Authors: Attia Najmeddine , Selmi Bilel
Published: February 2020

Given two probability measures ? and ? on Rn. We define the upper and lower
relative multifractal box-dimensions of the measure ? with respect to the
measure ? and investigate the relationship between the multifractal
box-dimensions and the relative multifractal Hausdorff dimension, the
relative multifractal pre-packing dimension. We also, calculate the relative
multifractal spectrum and establish the validity of multifractal formalism.
As an application, we study the behavior of projections of measures obeying
to the relative multifractal formalism.
Solving balanced multi-weighted attribute set partitioning problem with variable neighborhood search
Authors: Dzamic Dusan , Cendic Bojana , Maric Miroslav , Djenic Aleksandar
Published: February 2020

This paper considers the Balanced Multi-Weighted Attribute Set Partitioning
(BMWASP) problem which requires finding a partition of a given set of
objects with multiple weighted attributes into a certain number of groups so
that each attribute is evenly distributed amongst the groups. Our approach
is to define an appropriate criterion allowing to compare the degree of
deviation from the ?perfect balance? for different partitions and then
produce the partition that minimizes this criterion. We have proposed a
mathematical model for the BMWASP and its mixed-integer linear
reformulation. We evaluated its efficiency through a set of computational
experiments. To solve instances of larger problem dimensions, we have
developed a heuristic method based on a Variable Neighborhood Search (VNS).
A local search procedure with efficient fast swap-based local search is
implemented in the proposed VNS-based approach. Presented computational
results show that the proposed VNS is computationally efficient and quickly
reaches all optimal solutions for smaller dimension instances obtained by
exact solver and provide high-quality solutions on large-scale problem
instances in short CPU times.
Completeness of a normed space via strong p-Cesàro summability
Authors: Léon-Saavedra F. , Moreno-Pulido S. , Sala-Pérez A.
Published: February 2020

In this paper we will characterize the completeness and barrelledness of a
normed space through the strong p-Ces?ro summability of series. A new
characterization of weakly unconditionally Cauchy series and unconditionally
convergent series through the strong p-Ces?ro summability is obtained.
Pseudo-B-Fredholm operators, poles of the resolvent and mean convergence in the calkin algebra
Authors: Berkani Mohammed , Zivkovic-Zlatanovic Snezana
Published: February 2020

We define here a pseudo B-Fredholm operator as an operator such that 0 is
isolated in its essential spectrum, then we prove that an operator T is
pseudo-B-Fredholm if and only if T = R + F where R is a Riesz operator and
F is a B-Fredholm operator such that the commutator [R,F] is compact.
Moreover, we prove that 0 is a pole of the resolvent of an operator T in the
Calkin algebra if and only if T = K + F, where K is a power compact operator
and F is a B-Fredholm operator, such that the commutator [K,F] is compact.
As an application, we characterize the mean convergence in the Calkin
algebra.
AB-wavelet frames in L2(Rn)
Authors: Srivastava Hari , Shah Firdous
Published: February 2020

In order to provide a unified treatment for the continuum and digital realm
of multivariate data, Guo, Labate, Weiss and Wilson [Electron. Res. Announc.
Amer. Math. Soc. 10 (2004), 78-87] introduced the notion of AB-wavelets in
the context of multiscale analysis. We continue and extend their work by
studying the frame properties of AB-wavelet systems {DADBTk??(k ? Zn; 1 <?
? <? L)}in L2(Rn). More precisely, we establish four theorems giving
su_cient conditions under which the AB-wavelet system constitutes a frame
for L2(Rn). The proposed conditions are stated in terms of the Fourier
transforms of the generating functions.
Sequential warped products: Curvature and conformal vector fields
Authors: De Uday , Shenawy Sameh , Ünal Bülent
Published: February 2020

In this note, we introduce a new type of warped products called as sequential
warped products to cover a wider variety of exact solutions to Einstein?s
field equation. First, we study the geometry of sequential warped products
and obtain covariant derivatives, curvature tensor, Ricci curvature and
scalar curvature formulas. Then some important consequences of these
formulas are also stated. We provide characterizations of geodesics and two
different types of conformal vector fields, namely, Killing vector fields and
concircular vector fields on sequential warped product manifolds. Finally,
we consider the geometry of two classes of sequential warped product
space-time models which are sequential generalized Robertson-Walker
space-times and sequential standard static space-times.
K-metric antidimension of some generalized Petersen graphs
Authors: Kratica Jozef , Kovacevic-Vujcic Vera , Cangalovic Mirjana
Published: February 2020

Resistance of social graphs to active attacks is a very important feature
which must be maintained in the modern networks. Recently introduced
k-metric antidimension graph invariant is used to define anew measure for
resistance of social graphs. In this paper we have found and proved the
k-metric antidimension for generalized Petersen graphs GP(n, 1) and GP(n,2). It is proven that GP(2m+1,1) and GP(8,2) are 2-metric antidimensional,
while all other GP(n,1) and GP(n,2) graphs are 3-metric antidimensional.
Existence and asymptotic behavior of intermediate type of positive solutions of fourth-order nonlinear differential equations
Authors: Djordjevic Katarina , Manojlovic Jelena
Published: February 2020

Under the assumptions that p and q are regularly varying functions satisfying
conditions ??a t/p(t)1/? dt < ? and ??a (t/p(t))1/? dt = ? existence
and asymptotic form of regularly varying intermediate solutions are studied
for a fourth-order quasilinear differential equation (p(t)jx??(t)|?-1
x??(t))?? + q(t)|x(t)|?-1 x(t) = 0, ? > ? > 0. It is shown that under
certain integral conditions there exist two types of intermediate solutions
which according to their asymptotic behavior is to be divided into six
mutual distinctive classes, while asymptotic behavior of each member of any
of these classes is governed by a unique explicit law.
Partial S-metric spaces and coincidence points
Authors: Simkhah Asil , Sedghi Shaban , Mitrovic Zoran
Published: February 2020

In this paper, the concept partial S-metric space is introduced as a
generalization of S-metric space. We prove certain coincidence point
theorems in partial S-metric spaces. The results we obtain generalize many
known results in fixed point theory. Also, some examples show the
e_ectiveness of this approach.
Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride
Authors: Wedian Fadel , Lataifeh Anas , Mohammed Makaseb S.
Published: February 2020

Green and sensitive spectrofluorometric methods have been developed and validated for the determination of timolol maleate (TML)/hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH)/hydrochlorothiazide in tablets. The proposed spectrofluorometric procedures were found to be linear in the range of 4–12, 5–35 and 0.025–0.2 mg L−1 for HCT, TML and AMH, resp. The excitation and emission wavelengths for HCT, TML and AMH at room temperature were 270 and 375, 295 and 435, 330 and 415 nm, resp. The methods were validated with respect to ICH guidelines. The AMH showed higher sensitivity with lower values of LOD and LOQ values compared to HCT and TML. The proposed methods were applied to two pharmaceutical formulations; the method for HCT and AMH has proven as reliable assaying method, whereas the method for TML, when combined with HCT, is applicable to screening semi-quantitative analyses.
Field Extensions and Kronecker’s Construction
Authors: Schwarzweller Christoph
Published: February 2020

This is the fourth part of a four-article series containing a Mizar [3], [2], [1] formalization of Kronecker’s construction about roots of polynomials in field extensions, i.e. that for every field F and every polynomial p ∈ F [X]\F there exists a field extension E of F such that p has a root over E. The formalization follows Kronecker’s classical proof using F [X]/
 as the desired field extension E [6], [4], [5].

In the first part we show that an irreducible polynomial p ∈ F [X]\F has a root over F [X]/
. Note, however, that this statement cannot be true in a rigid formal sense: We do not have F ⊆ F [X]/ < p > as sets, so F is not a subfield of F [X]/
, and hence formally p is not even a polynomial over F [X]/ < p >. Consequently, we translate p along the canonical monomorphism ϕ: F → F [X]/
 and show that the translated polynomial ϕ (p) has a root over F [X]/
.

Because F is not a subfield of F [X]/
 we construct in the second part the field (E \ ϕF)∪F for a given monomorphism ϕ: F → E and show that this field both is isomorphic to F and includes F as a subfield. In the literature this part of the proof usually consists of saying that “one can identify F with its image ϕF in F [X]/
 and therefore consider F as a subfield of F [X]/
”. Interestingly, to do so we need to assume that F ∩ E = ∅, in particular Kronecker’s construction can be formalized for fields F with F ∩ F [X] = ∅.

Surprisingly, as we show in the third part, this condition is not automatically true for arbitrary fields F : With the exception of ℤ2 we construct for every field F an isomorphic copy F′ of F with F′ ∩ F′ [X] ≠ ∅. We also prove that for Mizar’s representations of ℤ
n
, ℚ and ℝ we have ℤ
n ∩ ℤ
n
[X] = ∅, ℚ ∩ ℚ[X] = ∅ and ℝ ∩ ℝ[X] = ∅, respectively.

In this fourth part we finally define field extensions: E is a field extension of F iff F is a subfield of E. Note, that in this case we have F ⊆ E as sets, and thus a polynomial p over F is also a polynomial over E. We then apply the construction of the second part to F [X]/
 with the canonical monomorphism ϕ: F → F [X]/
. Together with the first part this gives – for fields F with F ∩ F [X] = ∅ – a field extension E of F in which p ∈ F [X]\F has a root.
China’s Foreign Policy and its Choice for Cultural Soft Power: The Tools
Authors: Rahman Saifur
Published: February 2020

Chinese soft power can be assessed in many aspects because there are several tools in which soft power can manifest. This article seeks to assess the efficiency of China’s soft power using four tools from the perspective of public diplomacy. The analysis helps us to better understand the efficiency of foreign public communication tools. The paper is mainly qualitative research from collected secondary materials, following Mark Leonard’s (2002) concept of three dimensions of public diplomacy. The tools considered are: the Confucius institute (cultural institutes); Belt and Road initiative summit 2017 (international events); China central television/CCTV (media); International Students (financial aid for researchers and students). The analysis uses the three dimensions of public diplomacy: daily communication, strategic communication, and long-term communication. There is no indication that any of the selected four tools resonates with any of the three dimensions of public diplomacy. Some tools resonate more than others with a particular dimension of public diplomacy, but nothing is set in place. The media use daily communication quite effectively. International events are more so in strategic communication. Both international students and the cultural institute have an advanced role in long-term communication. However, the three dimensions are important to asses expected outcomes in foreign relations. A single tool could not effectively serve all concerns for getting support within the international community. The limitations of a tool can curb its appeal for a particular dimension, while advantages of the same tool spring in another.