bluuebunny/crossref_metadata_2025 huggingface dataset:
The dental pulp chamber evaluation by using cone-beam computed tomography
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Samson Stella , Nacu Viorel ,   Nicolae Testemitanu State University of Medicine and Pharmacy
Published: May 2021

Background: Cone-beam computed tomographic (CBCT) imaging is a valuable tool in dental practice. It is widely used in endodontic treatment for the root canal morphology examination. Therefore, the purpose of this study was to use CBCT to calculate the volume of the pulp chamber at different tooth groups. Material and methods: This study conforms to protocols approved and in accordance with the ethics committee’s requirements, informed consent was obtained from each patient. Morphologic measurements of 120 maxillary and 120 mandibular molars (from 40 patients, aged 18–45 years) were included in this study. CBCT images were taken using a Kodak 9500 (Dental Systems, Carestream Health) operated at 90 kVp with a voxel size of 300 mm and a field of view of 90-50 mm. All scans were taken following the manufacturer’s recommendation protocol. According to the examination requirements, C-shaped roots, single-rooted molars, crowned teeth, and teeth with caries and/or restorations violating the pulp chamber were excluded. All measurements were taken on the coronal plane view. Results: In the present study, we used CBCT imaging to gather information regarding pulp chamber volume. With the scanned 3-dimensional images, we were able to clinically determine the pulp chamber parameters using a standardized and defined spatial approach. Conclusions: The data we collected here serve as a proof of principle for the analysis of dental landmarks before collecting stem cells. In this particular study, existing CBCT scans were used to provide useful information that can be used as a guide to determine the volume of the pulp chamber
Experimental substantiation of hyperthermic exogenous and endogenous factors prompt neutralization in burn injuries
Authors:   National Pirogov Memorial Medical University, Vinnytsya, Ukraine, Chornopyshchuk Roman
Published: May 2021

Background: High mortality and disability of patients with critical and supercritical burns, long-term treatment, unsatisfactory aesthetic and functional results lead to the search for ways to provide assistance aimed at counteracting the formation of a mass of necrotic tissue, which is crucial for life or death of the victim. Material and methods: The experimental study was performed on 60 sexually mature Wistar rats, which were on a regular diet and weighed 150-160 g. The experimental animals were divided into the main and control groups and were used to simulate burns with boiling water of IIb degree. Results: The traumatic effect of hyperthermic exogenous and endogenous damage factors of the animals in the main group were immediately neutralized by a gauze napkin soaked in water at a temperature of 18-20 ° C immediately after the simulation of burns, the duration of which became the criterion for dividing them into subgroups. In animals of subgroup 1 the time of application of a wet wipe to the burn area was 1 min., in the 2nd subgroup it was 5 min., 3rd subgroup – 10 min., 4th subgroup – 15 min., 5th subgroup – 20 min. The application napkin was changed when it was heated to 34 °C. Such applications were not performed to the animals of the control group. Conclusions: The conclusion was made on the necessity of prompt neutralization of traumatic action of hyperthermic exogenous and endogenous damage factors as the main elements of burn wound depth. For a broader understanding of action mechanisms of the suggested technology of self-help and mutual first aid as well as the nature of the impact of neutralization directly on the tissues, it is advisable to supplement the research with morphological methods
Comparative analysis of the skin decellularization methods
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Macagonova Olga , Risnic Doina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Cociug Adrian ,   2 Human Tissue Bank, Orthopedic and Traumatological Hospital, Chisinau the Republic of Moldova, Nacu Viorel ,   Nicolae Testemitanu State University of Medicine and Pharmacy
Published: May 2021

Background: The extracellular matrix plays an important role in the promoting the tissue regeneration and repair. Decellularization or removal of the cells from the complex mixture of the structural and functional proteins that constitute the extracellular matrix (ECM) can be done by the physical (agitation, sonication, freeze and thaw), chemical (alkaline orchids, ionic detergents, nonionic, tri-n-butyl phosphate (TBP), hypotonic or hypertonic treatments, chelating agents), and enzymatic methods (trypsin or protease inhibitors). However, complications associated with the use of the decellularized skin have been reported, which are widespread and poorly understood. In this synthesis have been included publications, identified by the Google Search engine, National Bibliometric Tool (NBT), Pub Med databases, Web of Science, Springer, Elsevier, Wiley Online Library, Science Direct and Biosience, Biotechnology and Biochemistry. The results of the decellularization were reported in terms of the number of cells remaining in the collagen fibers depending on the duration of exposure to chemical agents. Conclusions: The natural matrix is more widely used than synthetic material, because it has the natural structure and composition of the ECM, it naturally stimulates cell development and allows the incorporation of the growth factors and other proteins increasing cell proliferation.The assessment of the quality of decellularization techniques is done by evaluating the necrosis of the extracellulare matrix, the depletion of the collagen fibers and the remaining amount of genetic material.
Kepemimpinan Visioner Kepala Sekolah Terhadap Mutu dan Kualitas Sekolah di SD Negeri Soko
Authors: Purwanto Rati
Published: May 2021

Maju atau mundurnya sebuah institusi ditentukan oleh gaya kepemimpinan, demikian pula di lembaga pendidikan seperti sekolah, sekolah akan mengalami kemajuan yang pesat apabila pemimpinnya mempunyai gaya kepemimpinan yang tepat. Salah satu gaya kepemimpinan untuk meningkatkan mutu dan kualitas adalah gaya kepemimpinan visioner. Meningkatkan mutu dan kualitas pendidikan dalam lembaga persekolahan sangatlah sulit jika tidak diiringi dengan peningkatan kinerja guru. Hal ini disebabkan karena guru merupakan komponen yang paling menentukan dalam sistem pendidikan secara keseluruhan yang harus mendapatkan perhatian sentral. Kepemimpinan visioner ini dapat memberikan pengaruh yang signifikan terhadap peningkatan kinerja guru karena kepala sekolah dapat memberikan visi yang jelas dan dapat mengimplementasikan visi yang telah dibuatnya untuk masa depan guru tersebut, sehingga dengan peningkatan kinerja guru diharapkan terjadi peningkatan pula terhadap mutu dan kualitas pendidikan di SD Negeri Soko. Best practice ini, kepemimpinan visioner kepala sekolah memiliki sub variabel : Fokus pada tujuan organisasi; Membuat rencana jangka panjang; Mengembangkan Visi Bagi Masa Depan Organisasi; Selalu Berada dalam Kondisi Siap dan Dinamis untuk Perubahan; dan Selalu Mengetahui Perubahan Kebutuhan Konstituen. Kepemimpinan visioner kepala sekolah dan kinerja mengajar guru berpengaruh secara positif dan signifikan terhadap efektivitas sekolah pada Sekolah Dasar Negeri. Hal ini mengindikasikan efektivitas sekolah ditentukan oleh kepemimpinan visioner kepala sekolah dan kinerja mengajar guru secara bersama-sama. Semakin baik kepemimpinan visioner kepala sekolah dan kinerja mengajar guru maka efektivitas sekolah akan semakin baik dan mengalami peningkatan.
Pengembangan Buku Panduan Membaca Cerita Sebagai Bahan Ajar Tambahan Memahami Cerita Untuk Siswa Kelas IV Sekolah Dasar
Authors: Zahro Elma Asfiatuz , Yuda Maria Ulfa , Widiastuti Sripit
Published: May 2021

Tujuan pengembangan bahan ajar dalam penelitian ini adalah untuk menghasilkan bahan ajar yang dapat meningkatkan pemahaman siswa terhadap isi cerita yang dibaca dengan panduan sebelum membaca cerita untuk siswa kelas IV SD. Panduan membaca cerita yang digunakan dikaitkan dengan materi unsur intrinsik cerita yang dipaparkan secara bertahap. Penelitian ini menggunakan jenis penelitian dan pengembangan dari model Borg and Gall yang telah diadopsi dan dikembangkan oleh Sugiyono. Adapun tahapan  penelitian dan pengembangan hanya dibatasi 7 tahapan penelitian. Ketujuh tahapan tersebut adalah mencari potensi dan masalah, melakukan penelitian dan pengumpulan data, desain produk, validasi desain, revisi desain, melakukan uji coba produk, dan revisi produk. Validasi buku pancarita ini dilakukan oleh validator materi, bahasa, dan media. Hasil validasi buku PANCARITA menunjukkan bahwa (1) validasi ahli media diperoleh persentase 90% dan termasuk kategori sangat layak, (2) validasi  ahli materi 85% termasuk kategori layak, (3) validasi  ahli bahasa 88% termasuk kategori layak. Hasil uji keterbacaan siswa menunjukkan kategori sangat layak dengan persentase 95%. Hasil uji keterbacaan guru menunjukkan kategori sangat layak dengan persentase 93%.
Aproximación a los observatorios de medios de comunicación en Colombia
Authors: Pérez Bonfante Federico , Uribe Metrio Ovet
Published: May 2021

Este artículo da cuenta de una investigación realizada en 2019 que tuvo por objeto indagar observatorios de medios de comunicación (OMC) activos en Colombia para identificar coincidencias y diferencias en relación con cuatro asuntos puntuales: contexto en el que surgieron, base teórica, temas prioritarios de indagación y literatura publicada. Lo anterior de cara a ganar pistas para pensar un OMC para Unicatólica.
Abstract
This article provides a detailed account of a research that took place in 2019. The main goal of such research was to investigate active media observatories in Colombia in order to recognize differences and coincidences in four main subjects: context in which they were created, theoretical framework, subjects of investigation and publications.
CAN GANODERMA LUCIDUM BE AN ALTERNATIVE NUTRITIONAL SUPPLEMENT FOR ENHANCING SPERM MOTILITY RATE?
Authors: BÜYÜK Başak , DEMİRCİ Tuba , DEMİR Neslihan , TÜRKÖN Hakan
Published: May 2021

Ganoderma lucidum (GL) is a widely used medicinal mushroom. The therapeutic effect of this fungus on many diseases has been proven by studies. The aim of this study is to assess the effects of low, moderate and high dose GL extract administration on the testis tissue, spermatogenic series cells and sperm motility in rats. 40 Wistar albino rats were randomly divided into 4 groups. Rats in group 1, 2, 3 and 4 were administered 2 ml physiologic serum, 500 mg/kg, 2500 mg/kg, 5000 mg/kg Ganoderma lucidum extract 1 time per day via gavage for 9 days, respectively. For evaluation of sperm motility and histopathological changes, epididymal sperm collection and testis harvesting were done. Blood samples were collected for biochemical analysis. When the Group 1 (control group) is compared with Groups 2, 3 and 4, the Johnsen score and sperm motility in these groups increased and this increase was statistically significant. In conclusion, low, moderate, and high doses of GL extract administered to rats were revealed to increase spermatogenesis, epididymal total sperm count and progressive motile sperm counts. However, it is detected that high doses cause minimal damage to the testis and as the increase in sperm parameters wasn’t significant, it’s concluded that doses for oral use above 2500 mg/kg should be avoided.
COVİD-19 TANISIYLA HASTANEDE YATAN HASTALARDA ANKSİYETE VE UYKU BOZUKLUĞU BELİRTİLERİNİN SOSYODEMOGRAFİK VE KLİNİK FAKTÖRLERLE İLİŞKİSİ
Authors: EGELİ Aslı , GUC Bulut , KALENDEROĞLU Aysun , ÖRÜM Mehmet Hamdi , BALTACI Elif , KAPICI Yaşar , SAYİNER Hakan Sezgin , ÇİL Ercan
Published: May 2021

Bu çalışmadaki amacımız COVİD-19 tanısıyla yatırılarak tedavi altına alınan hastaların anksiyete belirtileriyle uyku sorunlarının sosyal ve klinik değişkenlerle ilişkisini araştırmaktır. Kesitsel özellikteki bu çalışmaya Eğitim ve Araştırma Hastanesi’nde 01.06.2020-31.08.2020 tarihleri arasında COVİD-19 tanısıyla yatırılarak tedavi edilen hastalar dâhil edildi. Sosyodemografik veriler kaydedildi ve tüm olgulara Uykusuzluk Şiddeti İndeksi (UŞİ) ve Hamilton Anksiyete Değerlendirme Ölçeği (HADÖ) uygulandı. Ortalama yaşı 46,46±15,39 yıl olan 78 (28 kadın, 50 erkek) olgu değerlendirildi. Yaş (p=0,784) ve meslek (p=0,480) cinsiyetler arasında benzerdi. Kadınlarla erkekler arasında UŞİ skoru açısından farklılık saptanmazken (p=0,625), HADÖ skoru kadınlarda anlamlı olarak daha yüksekti (p=0,022). Pandemi sürecinde uyku sorunları yaşadığını bildirenlerle bildirmeyenlerin ortalama yaşı (p=0,264) benzerdi; UŞİ skoru (p
EFFECTS OF ELECTRONIC MEDIA IN POLITICAL OPINION FORMATION OF YOUTH IN PAKISTAN
Authors:   Department of Sociology, Karakoram International University Diamer Campus, Chilas, Tahir Muhammad , Ur Rehman Shuja ,   Department of Sociology Karakoram International University Diamer Campus, Chilas, Ur Rehman Aziz ,   Department of Political Science Qurtaba University, Peshawar
Published: May 2021

This study aimed to understand the impact of electronic and social media sources in progression of political understanding, and political participation of youth in Pakistan. This study further explains the learning process through media as it has emerged as one of the strongest agents of socialization in the recent times. A sample size of 329 respondents (graduate level students) was selected systematically from public sector higher educational institutions in Khyber Pakhtunkhwa (KP) and Gilgit-Baltistan (GB) Pakistan. The data was analyzed through chi-square test to determine the relationship between political participation and youth behavior. A significant relationship (p=0.017) was found between medias programs’ efficiency and decisions of government on various national and international issues with youth behavior. It is proved that formation of opinion on the helm of authority largely influenced by media. There was a strong and significant relationship (p=.000) between political party’s agendas bring forth by media sources to gain mass support or vote. It indicatesthat political talk shows and advertisements on electronic media have manipulated minds of masses. Political campaign via electronic media effects youth behavior proved significant (p=.001). A strong association was also proved between media efforts to motivate people and bring them to vote (p=0.000) with youth behavior shows the efficiency and worth of media programs for the sustainability of democratic values. Again media proved its decisive role in establishing the public opinion about various political parties and their role in national interests, their zeal and synergies spending on national cause. Political parties motivate people through advertisements and conveying their vision, mission to their voters. Relation of media advertisement and youth’s opinion was strongly significant (p=0.000) with youth behavior. It again showed that media as a tool can be very useful to mass mobilization for political purposes. The study concluded that media can play a pivotal role in motivating youth to become politically active as it works as catalysts in upbringing the latest information to the recipients and can succeed in determining a position of trust among the viewers. The study recommended that electronic media should focus on its programs to bring more reality and standard, making it more trustworthy, valid and reliable. It can be beneficial for youth, researchers and policy makers. Keywords: political attitude, infotainment, socialization, electronic media, youth behavior
Risk Factors of Childhood Diarrhoeal Diseases in Bangladesh: Evidence from a Nationwide Cross-sectional Survey
Authors: SİDDİQİ Md. Nure Alam , MUYEED Abdul
Published: May 2021

Globally, different episodes of diarrhoeal diseases are one of the leading causes of childhood morbidity and mortality, especially in developing countries. Diarrhoeal diseases among children under five years of age have been considered as the major causes of morbidity and mortality in Bangladesh although it has declined recently. In this study, the most recently published Multiple Indicator Cluster Survey 2019 (MICS 2019) data were used to observe the prevalence of childhood diarrhoea and to identify the socio-economic and demographic risk factors of childhood diarrhoea in Bangladesh. The chi-square test was used in this study to identify the risk factors of childhood diarrhoeal diseases in Bangladesh. The overall prevalence of diarrhoea among children under five years of age in Bangladesh was found 6.9% in the last two weeks preceding the survey. The findings of the study identified that child age less than two years, an unimproved facility of toilet or source of drinking water, floor material made of earth/sand, no handwashing place observed in dwelling/ yard/plot, lower or no education of mothers and household heads, lower economic status, three or more under-five children living in the family are the most potential risk factors of childhood diarrhea in Bangladesh. Improved source of drinking water supply, better sanitation, hygiene practice, mother’s knowledge and consciousness about diarrhoea and, timely treatment and can reduce the burden of childhood diarrhoea in Bangladesh. The quality of existing child healthcare services like oral rehydration therapy (ORT) during diarrhoea, rotavirus vaccination programs should be improved at all stages without any discrimination which will contribute to a reduction in childhood morbidity and mortality due to diarrhoea in Bangladesh.
Method Development and Validation of Droxidopa by RP-UPLC
Authors: Pandilla Bharani , Chitra K. , Nalini C. N. , P. Ashok
Published: May 2021

A simple, rapid, accurate and economical method has been developed for the quantification of droxidopa by UPLC. The chromatographic system was equipped with Phenomenex column C18 (50mm x 3.0mm, 3µ) as stationary phase and UV detector at 235nm, in conjunction with a mobile phase of buffer: methanol (25:75 % v/v ratio) at a flow rate of 1.0mL/min. Linearity was observed over the concentration range of 100-300µg/mL for droxidopa. The droxidopa peak eluted at 0.35 min. The recovery of Droxidopa was found to be 100.17% - 100.63% respectively. Statistical techniques were employed for the validation of precision, linearity, accuracy, robustness and ruggedness and can be applied for routine analysis. Validation revealed that the developed method was specific, accurate, precise, reliable, robust, reproducible and suitable for the routine quantitative analysis.
A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study
Authors: Saeed AL-Japairai Khater Ahmed , Chatterjee Bappaditya , Mahmood Syed , Hamed Almurisi Samah
Published: May 2021

The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.
Study on conditions for Gama buryric acid (GABA) production in Lactobacillus fermentum A01 isolated from human
Authors: Thien Phuc Cat , Thanh Vinh Doan Thi , Khoa My Truong , Thu Hien Tran Thi , Anh Dung Nguyen , Minh Thu Tran Thi , Khue Nguyen Tu Hoang
Published: May 2021

Lactic acid bacteria play a vital role in biosynthesis of γ -aminobutyric acid (GABA) in the presence of glutamic acid - major substrate for the process. In recent study, Lactobacillus fermentum A01 (L. fermentum A01) isolated from various sources in Vietnam were screened for bacteria strains with high efficiency in GABA formation. L. fermentum was cultured in MRS broth containing 25 mg/mL monosodium glutamate (MSG), at pH of 6.5 and incubated at the optimal conditions (37ºC, for 24, 48, 72 h). After extraction and thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis, L. fermentum A01 showed the GABA yield about 1.34 mg/g in dried supernatant, suggesting L. fermentum A01 to be a promising GABA producer for food and pharmaceutical applications.
Molecular Docking Q-SAR Studies of Benzimidazole as Antifungal Nucleus
Authors: Aanandhi M. Vijey , Sachin J Anbhule
Published: May 2021

Benzimidazole and its derivatives are used in organic synthesis and vermicides or fungicides as they inhibit the action of certain microorganisms. The molecules to be analysed were aligned on an appropriate template, which is considered to be common substructure. The protein structure of PDB name along with their inhibitor was retrieved from RCSB Protein Data Bank (PDB entry code: 6T1O). The protein structure were subjected to energy minimization and charge calculation (AMBER7FF99), docking score of compounds on 6T1O PDB describe the ligand interaction. Virtual library of benzimidazoles derivatives to find lead structures to test against C. albicans. Twenty compounds were designed in which heterocyclic ring is substituted at NH group of Substituted ortho-phenylenediamine moiety while some compound also bearing chloro and nitro group on para position of aromatic ring.
Wound Healing Potential of Polyherbal Formulation in Rats
Authors: Kumar Rohit , Gupta Reena , Kumar Bimlesh , Kapoor Bhupinder
Published: May 2021

Chronic wound infections are significant medical burden as the patients have to go through severe discomfort and distress. Invasion of various pathogenic microorganisms at the injured site further leads to damage of tissue which may results in resection of the organ. Appropriate wound healing is necessary to regain the functional and anatomical status of the damaged tissue that got disturbed due to wound. Conventional antibiotics used for the treatment of infections are associated with various drawbacks such as high cost and high incidence of resistance. Moreover, the dressing used for wounds are also unable to provide adequate moisture to the injured tissue. All these factors emphasise on the development of new advanced technologies for wound care. Polyherbal formulations, which comprise of various medicinal plant extracts, exhibit antioxidant and anti-inflammatory properties and can be much better alternative to commercial antibiotics for treatment of wound infections. In the present study, wound healing potential of “Septaheal” (a Polyherbal formulation) was evaluated in Wistar albino rats using incision, excision and burn wound models. The formulation exhibited wound healing property due to its angiogenic and mitogenic potential.
Free radical scavenging, Thrombolytic and cytotoxic effects of the medicinal herb, Crassocephalum crepidioides
Authors: Kabir Md. Tanvir , Samiha Mayesha , Yasmin Hasina , Rahman Mohammed S. , Rahman Md. Sohanur , Md Ashraf Ghulam , Akter Raushanara
Published: May 2021

Crassocephalum crepidioides belongs to the Asteraceae family and the leaves of the plant were used in the phytochemical screening. The objective of this study was phytochemical analysis of C. crepidioides in order to evaluate its antioxidant, thrombolytic and cytotoxic effects. In this study, DPPH assay and total phenolic content (TPC) were used to evaluate the antioxidant property. Brine shrimp lethality test was performed to find the cytotoxicity. The TPC of methanolic extract of C. crepidioides was 637.22 mg/gm and gallic acid was standard in this procedure. The IC50 value of the plant extract of DPPH assay was 136.016 μg/mL obtained by using ascorbic acid as reference standard. Furthermore, the obtained IC50 value of ascorbic acid was 94.12 μg/mL. In this study, lethal concentrations of vincristine sulfate and the plant extract were 3.064 μg/mL and 69.245 μg/mL respectively. Indeed, the plant exhibited significant antioxidant, cytotoxic and thrombolytic activity.
Development of Capsule containing Immediate Release Tablet and Extended Release Floating Tablet for Monitoring Release of Atenolol
Authors: Kolhe Mahesh Hari , Gilhotra Ritu Mehra , Asane Govind Sarangdhar
Published: May 2021

Atenolol is beta blocker absorbed through GIT use for heart diseases. Single tablets, floating tablets and sustained released formulations studied are insufficient to produce effective dose to enhance bioavailability and effectiveness. Our study is focused on development of capsule dosage form containing immediate release (IR) and floating extended release (ER) tablets for monitoring release of atenolol in single dosage form. Two different tablets for IR and ER were prepared in three different combinations (Batch). Pre-formulation and post formulation parameters found to be within acceptable limits of formulation. Release behavior of individual tablets and capsule containing two tablets were studied. Among the batches, capsules containing smaller amount of atenolol in IR and large amount of Atenolol in ER (batch II) showed impressive drug release pattern. This formulation was stable even after a month and achieved optimum release behavior of immediate release and sustained release. This study could be used for effective treatment for different heart complications and reduce toxicity due to high plasma concentration in increased dose frequency.
Effect of Cervical Extensor Strengthening on severity of Temporomandibular Joint Disorder among University students: A Randomized controlled trial
Authors: Thiruvevenkadam Ilayaraja Alagia , Ling Lee Tze
Published: May 2021

Background and Objectives: Awareness of temporomandibular joint disorder (TMD) is fairly concerning in management of physiotherapy as patients often seek for treatment from orthodontics when pain become their main concerns. In this case, cervical aspects are often overlooked in the treatment of temporomandibular joint disorder. This study aims to determine the effect of cervical extensor strengthening on severity of temporomandibular joint disorder. Methods: A randomized controlled trial study was carried out for 4 weeks to determine the effect of cervical extensor strengthening on severity of temporomandibular joint disorder among university students. A total of 40 participants were recruited via convenient sampling method. Subjects were randomly assigned into two groups: experimental group (E) and control group (C) through lottery randomization. Subjects in experimental group were instructed to perform 1 set of cervical extensor strengthening with 10 repetitions and goldfish exercises whereas subjects in control group were asked to perform goldfish exercises only. A pre-test and post-test severity of TMD, maximal mouth opening and maximal isometric cervical extensor strength were measured for both groups. Results: After 4 weeks of training, there was significant difference in pre-test and post-test severity of TMD and maximal mouth opening for both E and C group. On the other hand, there was significant difference of pre and post-test of maximal isometric cervical extensor strength in experimental group. There was no significant difference in post-test for severity of TMD (p=0.67), maximal mouth opening (p=0.21) and maximal isometric cervical extensor strength (p=0.40) between two groups. Conclusions: The study concluded that, 4 weeks of anti-gravity cervical extensor strengthening exercises protocol showed there was no significantly difference of the severity of TMD and maximal mouth opening between both control and experimental group. On the other hand, goldfish exercises showed significant improvement of maximal mouth opening and reduction in severity of TMD after 4 weeks of intervention period.
Effect of Immunonutrition supplementation on Post-operative outcome after major Gastrointestinal surgery for Malignancy
Authors: Sivaprasadan Saraswathy , Paul Anju Kochupurackal , Surendran Sudhindran , Padma Uma Devi
Published: May 2021

This prospective, pilot study evaluated the effect of immunonutrition supplementation using Pentasure Immunomax® on recovery after major gastrointestinal (GI) surgery for malignancy. It included two groups of patients (n = 25 each) who underwent major GI surgery for malignancy in two units, one of which routinely gave Pentasure Immunomax® (L – arginine, omega 3 fatty acids and ribonucleic acids) for two weeks following surgery (Group 1) while the other did not (Group 2). The pre-operative nutritional status of the patients were assessed using Subjective Global Assessment (SGA) scale. Post-operatively the following parameters were compared between the two groups: complications (using Clavien Dindo scale), calorie intake, length of intensive care unit (ICU) and hospital stay using SPSS software, version 20.0. Based on the SGA score, 66% of the entire study population was moderately malnourished, while 6% were severely malnourished. On assessing the body mass index, 26 (52%) patients were found to be overweight or obese, out of which 16 patients were found to be moderately malnourished. The mean caloric intake in Group 1 was significantly more than in Group 2 (1112.7± 51.6 versus 874.8±56.7; p = 0.0032). There was, however, no significant difference between the two groups in complications, ICU or hospital stay. The incidence of malnutrition in patients undergoing major GI surgery for malignancy is high even amongst those who are overweight/obese. Use of immunonutrition may help in better attainment of adequate calorie in post-operative period.
Immuno protective potential of Sida schimperiana chloroform root extract against E. coli 018: K1 induced peritonitis in albino Wistar rats
Authors: Yeabyo Solomon , Teka M Zenebe , V. K Gopalakrishnan , K Kamalakararao , M Muthulingam , Chaithanya K Krishna
Published: May 2021

Objective: The present study was aimed to evaluate the in vivo immune protective potential of chloroform root extract of Sida schimperiana on E.coli 018:K1 induced peritonitis in albino Wistar rats. Methods: Acute toxicity of was performed by oral administration of S. schimperiana chloroform root extract (SSRCH) 5, 50, 300 and 2000mg/kg body of male albino Wistar and mortality was monitored for 14 days. Based on LD50, 1/10th, 1/5th cut-off values of the (SSRCH) plant extract was selected as a dose for E. coli induced peritonitis in albino Wistar rats. Wistar rats were pre-treated with 200 and 400mg/kg/bwt of SSRCH and Standard antibiotic Ofloxacin 5mg/Kg body weight was given oraly for a period of 7 days. The dosing regimens were started on day -1,-2, -3, 0, 1, 2 and 3 relative to the day of challenge (day 0) with 2×104 CFU of E. coli CFU/ml (i.p.) and mortality was monitored for 14 days. After the monitoring the mortality, the treated (Groups I-IV) rats were sacrificed, and assess the in vivo antibacterial activity of S. schimperiana chloroform root extract by determination of CFU/ml in peritoneal lavage fluid. Further SSRCH extract (400mg /kg bw) was analyzed by the neutrophil adhesion in Wistar rats for evaluated immunomodulatory activity. Results: In acute toxicity studies no mortality was observed for 24-48 hours. SSRCH extract 400mg (Group-IV) showed protection against E. coli induced peritonitis in albino Wistar rats by showing 60% survivability and also exhibited significantly increased percentage of neutrophils adhesion. i.e (25.74±2.351and 36.14±5.609) at 200 and 400mg/kg respectively. Conclusion: The present study concluded that the chloroform root extract of S. schimperiana had a significant amount of polyphenolic compounds and could serve as a potential source of natural antibacterial and Immunomodulatory agents for the development of therapeutic antibiotics with immunostimulatory activity in the treatment of intraperitoneal infections.
An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope
Authors: Tripathi Devika , Chaudhary Nandini , Kumar Sharma Dinesh , Sahoo Jagannath
Published: May 2021

Ketoprofen used as a Non-steroidal anti-inflammatory drug selected as a poorly water-soluble model drug. Due to the poorly soluble nature of Ketoprofen liberate reduced bioavailability. Hydrotropic solubilization technique is a promising technique used to improve the solubility of water-insoluble drugs. In this investigation, 2M sodium salicylate has been employed in the titrimetric estimation of Ketoprofen and shows synergistic enhancement in the solubility of Ketoprofen by many folds as compared to the distilled water. It excluded the use of various organic solvent like ethanol; methanol and chloroform widely utilized in the titrimetric estimation of various poorly soluble drugs but due to the higher cost, volatility, toxicities lead to environmental pollution hence are the cons of it. The proposed method is new, simple, precise, and inexpensive. The results of the analysis have been validated statistically. The mean % recoveries were found to be close to 100, indicating the accuracy of the proposed method. Low values of standard deviation, % coefficient of variation, and standard error further proved the reproducibility and precision of the proposed method.
Nanofibers – A Newer Technology
Authors: M.P. Ratnaparkhi , R.S. Andhale , G.R. Karnawat
Published: May 2021

Nanofibers are the fibers having diameter in nanometer ranging from 50-1000nm.Nanofibers can be prepared by using polymers like cellulose, silk, fibroin, keratin, gelatin, polylactic acid, polyurethane etc. The chain of polymers are connected by covalent bonds. The diameter of nanofibers depends on the type of polymers used in preparation method. There are various methods are used to fabricate nanofibers like electrospinning, thermal induced phase separation, drawing, template synthesis, self-assembly. Nanofibers are widely used in various fields like in filtration, affinity membrane and recovery of metal ions, tissue engineering, wound dressing, catalyst s; enzyme, carriers, sensor, energy conversion and storage, sound absorbtive material etc. Nanofibers are the newer technology which is widely used than the others due to large surface area. It has high porosity and small pore size hence it does not allow to bacterial infection due to larger size of bacteria. It has higher mechanical strength hence it is easy to use as compare to other.
Review on Arakoda (Tafenoquine) and its approach as an Anti-Malarial Agent.
Authors: Sana Syeda , Abed Mohsina
Published: May 2021

Tafenoquine is an analogue of primaquine with an improved therapeutic and safety profile. It has a long half-life and activity against liver-stage malaria parasites, so may be useful for chemoprophylaxis. Antimalarial agents are drugs used for the treatment or prophylaxis of malaria. Malaria is caused by four species of Plasmodium, such as Plasmodium falciparum, P. malariae, P. ovale, and P. vivax. Arakoda contains tafenoquine succinate, an antimalarial agent for oral administration. The molecular formula of tafenoquine succinate is C24H28F3N3O3∙C4H6O4 and its molecular weight is 581.6 as the succinate salt. It is given in prophylaxis of malaria patient aged 18 years older. Tafenoquine is active against pre-erythrocytic (liver) and erythrocytic (asexual) forms as well as gametocytes of Plasmodium species. G6PD test is performed before giving the drug. Analytical studies were on NMR, IR, MS, HPLC, Flourimetry analysis. In vitro studies have shown that tafenoquine presents an average 50% inhibitory concentration of 0.436mcg against blood stages of seven strains of P. falciparum. The long‐acting 8‐aminoquinoline tafenoquine (TQ) co-administered with chloroquine (CQ) may radically cure Plasmodium vivax malaria. Coadministration therapy was evaluated for a pharmacokinetic interaction and for pharmacodynamic, safety and tolerability characteristics. Volume of distribution. The activation of tafenoquine needs the activity of CYP 2D6 liver microsomal enzyme. Routes of elimination are through feces.
Structural Neuroimaging Findings in Autism Spectrum Disorder:
A Systematic Review
Authors: Yugander P. , Jagannath M.
Published: May 2021

Autism Spectrum Disorder (ASD) is widely developing neurodevelopmental disorder. The ASD is a lifelong neurodevelopmental disorder that effects the social interaction and behavior of human beings. In this review, we presented structural magnetic resonance imaging (sMRI) studies that were examined in structural brain abnormalities of ASD patients. To date sMRI results were distinct, due to the diversity of the ASD itself. The accelerated brain volume is the uniform finding of ASD. However, the recent investigation reports have started to interpret the structural abnormalities of ASD patient’s brain. The most common abnormalities found in total brain volume, cerebellum, amygdala, hippocampal, basal ganglia, insula, gray and white matter. Limited sMRI research has been done on less than 2 years ASD children. Future research should include autistic children less than 2 years along with functional MRI and diffusion tensor imaging.
Chương trình các môn Tự nhiên và Xã hội, Khoa học, Lịch sử và Địa lí ở tiểu học trong Chương trình giáo dục phổ thông mới
Authors: Dương Huy Cẩn
Published: May 2021

Chương trình Giáo dục phổ thông mới được xây dựng theo mô hình phát triển phẩm chất và năng lực học sinh. Nội dung, phương pháp giáo dục hướng đến giúp học sinh hoàn thành các công việc, giải quyết các vấn đề trong học tập và đời sống nhờ vận dụng hiệu quả và sáng tạo những kiến thức và kỹ năng đã học. Bài báo nêu ra những thay đổi cơ bản trong chương trình các môn Tự nhiên và Xã hội, Khoa học, Lịch sử và Địa lí ở tiểu học so với chương trình hiện hành được xây dựng theo định hướng nội dung.
Hình thành năng lực kiến tạo nhận thức cho học sinh trung học phổ thông qua việc rèn luyện kỹ năng làm văn nghị luận xã hội
Authors: Nguyễn Quang Hùng , Phan Thị Kim Dung
Published: May 2021

Theo quan điểm hiện đại, dạy học phải là quá trình chú trọng hướng tới “đánh thức” chủ thể tự giác, tích cực, linh hoạt, sáng tạo… của người học để thay đổi tư duy nhận thức. Trong quá trình dạy học ở trường trung học phổ thông nói chung và trong việc rèn luyện kỹ năng làm văn nghị luận xã hội nói riêng, người dạy cần “đánh thức”, hình thành cho người học năng lực kiến tạo nhận thức - đây chính là dạng năng lực tổng hòa không tách rời của năng lực kiến tạo tri thức, kỹ năng; năng lực kiến tạo tư duy; năng lực kiến tạo điều chỉnh thái độ, hành vi... Khi rèn luyện kỹ năng làm văn nghị luận xã hội, người dạy có nhiều cách để hình thành năng lực kiến tạo nhận thức cho người học như: chú trọng tới việc trang bị kiến thức, kỹ năng “nền”; gắn việc rèn luyện kỹ năng làm văn với việc đánh thức, phát triển năng lực kiến tạo tư duy;thay đổi mô hình rèn luyện kỹ năng trong dạy học làm văn nghị luận xã hội…
Thực trạng giảng dạy thực hành trong môn Sinh học tại các trường trung học phổ thông khu vực Đồng bằng sông Cửu Long và thành phố Hồ Chí Minh
Authors: Trần Thanh Thảo , Nguyễn Trọng Hồng Phúc
Published: May 2021

Bài báo tóm tắt thực trạng giảng dạy thực hành môn Sinh học tại các trường trung học phổ thông ở Đồng bằng sông Cửu Long và thành phố Hồ Chí Minh. Nghiên cứu được tiến hành trên 108 giáo viên Sinh học (76,19% nữ, 23,81% nam) thuộc ba khối 10, 11, 12 từ 86 trường và sử dụng bảng câu hỏi. Kết quả cho thấy 98,15% giáo viên khảo sát có dạy thực hành và trên 90% các giáo viên cho biết giảng dạy thực hành được quy định bắt buộc tại trường mình. Trong số các giáo viên khảo sát, có trên 2/3 giáo viên đã từng được tham gia các khóa tập huấn về thực hành. Về các chủ đề Sinh học được đưa vào giảng dạy thực hành, 100% các chủ đề thực hành của lớp 10, 11 và 12 đều được các giáo viên lựa chọn, trong đó các chủ đề lớp 10 và 11 được dạy với tỉ lệ cao hơn của lớp 12. Hầu hết các giáo viên đều cho rằng giảng dạy thực hành môn Sinh học có vai trò quan trọng đối với học sinh. Về các khó khăn, các giáo viên cho rằng việc thiếu cơ sở vật chất, thiếu tài liệu tham khảo, thiếu kinh phí và áp lực công việc cao là các khó khăn hàng đầu. Song song đó, các giáo viên cũng mong muốn được hỗ trợ về cơ sở vật chất và nguồn tài liệu tham khảo trực quan để nâng cao năng lực giảng dạy. Nghiên cứu này cung cấp nguồn thông tin có giá trị tham khảo cao nhằm phát triển các chính sách đổi mới giáo dục theo hướng chú trọng hoạt động thực hành trong giảng dạy môn Sinh học.
Kỹ năng thực hành của sinh viên ngành Công tác xã hội, Trường Đại học Đồng Tháp
Authors: Kiều Văn Tu
Published: May 2021

Kỹ năng thực hành công tác xã hội là một thành phần quan trọng góp phần hình thành năng lực thực hành công tác xã hội tổng quát. Bài viết làm sáng tỏ thực trạng những kỹ năng công tác xã hội của sinh viên Trường Đại học Đồng Tháp đã đạt được trong thời gian qua và những kỹ năng mong đợi đạt được. Đồng thời, bài viết làm rõ một số kinh nghiệm trong việc nâng cao kỹ năng công tác xã hội cho sinh viên góp phần đào tạo nguồn nhân lực công tác xã hội có chất lượng cao đáp ứng nhu cầu xã hội.
Tổ chức hoạt động trải nghiệm sáng tạo cho sinh viên Ngữ văn, Khoa Sư phạm, Trường Đại học An Giang
Authors: Nguyễn Thị Thu Giang
Published: May 2021

Hoạt động trải nghiệm là hoạt động giáo dục bắt buộc và giữ vai trò rất quan trọng trong chương trình giáo dục phổ thông mới. Để đáp ứng được những yêu cầu cấp thiết đó, Bộ môn Ngữ văn, Khoa Sư phạm, Trường Đại học An Giang đã có những hình thức và phương pháp tổ chức các hoạt động trải nghiệm sáng tạo một cách đa dạng và linh hoạt cho sinh viên bao gồm: hình thức thể nghiệm - tương tác, hình thức khám phá, hình thức nghiên cứu. Trên cơ sở đó, sau khi trở thành giáo viên, trong quá trình dạy học, họsẽ từng bước hình thành các năng lực tổ chức hoạt động trải nghiệm sáng tạo cho học sinh phổ thông.
Định hướng phát triển năng lực nghề nghiệp cho sinh viên ngành Nuôi trồng thủy sản Trường Đại học Đồng Tháp thông qua thực tập nghề nghiệp
Authors: Lê Thị Ngọc Mai , Trần Thanh Thuý
Published: May 2021

Định hướng phát triển năng lực nghề nghiệp cho sinh viên ngành Nuôi trồng thủy sản Trường Đại học Đồng Tháp là một mục tiêu quan trọng trong quá trình đào tạo. Phát triển năng lực nghề nghiệp là nhấn mạnh đến những kiến thức chuyên ngành, kỹ năng nghề nghiệp và thái độ đối với công việc cần được đào tạo, bồi dưỡng để hoàn thành một công việc của nghề nghiệp đạt hiệu quả cao. Với nội hàm phát triển năng lực nghề nghiệp này, bài viết tường minh hoá một số vấn đề về phát triển năng lực nghề nghiệp và theo đó đề xuất những định hướng phát triển năng lực nghề nghiệp cho SV ngành Nuôi trồng thủy sản Trường Đại học Đồng Tháp thông qua thực tập nghề nghiệp.
Huấn đức của Hồ Chí Minh: “Lấy tự học làm cốt. Do thảo luận và chỉ đạo giúp vào"
Authors: Đặng Quốc Bảo , Phạm Minh Giản , Tăng Thái Thuỵ Ngân Tâm
Published: May 2021

Hồ Chí Minh là tấm gương sáng về tinh thần tự học, có thể nói sự tự học đã góp phần lớn vào những thành công trong cuộc đời và sự nghiệp của Người. Trong tác phẩm Sửa đổi lối làm việc, Hồ Chí Minh khuyên cán bộ, đảng viên phải lấy tự học làm cốt, bên cạnh sự thảo luận và chỉ đạo. Bài viết phân tích ba nhân tố trên, vận dụng nó vào đổi mới giáo dục hiện nay; đồng thời giới thiệu một số nhận định của các nhà giáo dục hiện đại về kích thích tinh thần tự học trong thời đại ngày nay.
Phát triển văn hóa đọc cho sinh viên Trường Đại học Đồng Tháp - thực trạng và giải pháp
Authors: Nguyễn Thị Như Quyến
Published: May 2021

Văn hóa đọc trong môi trường giáo dục là yếu tố quan trọng để hình thành và phát triển nhân cách cho sinh viên nói chung. Văn hóa đọc giúp tăng khả năng nghiên cứu, tự học, nhận xét, đánh giá, tư duy tích cực và tư duy phản biện cho sinh viên. Đó là một trong những yếu tố góp phần nâng cao chất lượng giáo dục và đào tạo cho nhà trường. Thông qua công việc thực tiễn, đáp ứng nhu cầu phục vụ sinh viên ngày càng tốt hơn, chúng tôi đã đề xuất và thực hiện đề tài “Phát triển văn hóa đọc cho sinh viên”. Đây còn là cơ sở cho việc vận dụng các giải pháp đề xuất vào thực tiễn tại Trung tâm Thông tin Thư viện Lê Vũ Hùng, Trường Đại học Đồng Tháp. Bài viết này tác giả trình bày các nội dung như sau: Phương pháp nghiên cứu và cơ sở lí luận về phát triển văn hóa đọc; thực trạng văn hóa đọc của sinh viên Trường Đại học Đồng Tháp; qua đó đề xuất một số giải pháp cho vấn đề nghiên cứu.
Phát triển năng lực đặc thù cho học sinh trong dạy học môn Khoa học ở Tiểu học
Authors: Dương Huy Cẩn , Trần Thanh Nguyên
Published: May 2021

Theo xu hướng đổi mới giáo dục hiện nay, một chương trình dạy học khoa học tiên tiến đòi hỏi người học không chỉ có kiến thức, kĩ năng mà còn có thái độ và hứng thú đối với môn học. Hội nhập với sự phát triển giáo dục toàn cầu, giáo dục phổ thông nói chung, dạy học môn Khoa học ở Tiểu học đang hướng đến đổi mới mục tiêu dạy học theo định hướng phát triển phẩm chất và năng lực người học. Bài viết hệ thống các năng lực đặc thù trong môn Khoa học cần phát triển cho học sinh, từ đó đề xuất một số biện pháp phát triển năng lực đặc thù cho học sinh trong dạy học môn Khoa học.
"Thi ân mạc niệm, thụ ân mạc vong": Minh triết ứng xử trong nhà trường tạo ra động lực dạy - học chân chính
Authors: Đặng Quốc Bảo , Phạm Minh Giản , Tăng Thái Thuỵ Ngân Tâm
Published: May 2021

Người xưa có câu nói “Thi ân mạc niệm, thụ ân mạc vong” với ý nghĩa muốn nói rằng người làm ơn cho người khác việc gì có thể không cần ghi nhớ trong lòng, nhưng người mang ơn lại chắc chắn không thể quên ơn nghĩa kia. Câu nói này ứng vào trong văn hoá ứng xử nhà trường, liên hệ đến mối quan hệ giữa thầy và trò, có thể trở thành động lực dạy – học chân chính. Đó là người thầy luôn dốc hết sức mình truyền dạy tri thức, cách làm người cho học trò, nhưng không bao giờ cần hồi báo, nhưng học trò người nhận được sự dạy dỗ thì luôn luôn mang trong lòng sự biết ơn, kính trọng.
Optimization of Deviated and Horizontal Wells Trajectories and Profiles in Rumaila Oilfield
Authors: Almalikee Hussein Saeed , Al-Najm Fahad M.
Published: May 2021

Directional and horizontal wellbore profiles and optimization of trajectory to minimizeborehole problems are considered the most important part in well planning and design. Thisstudy introduces four types of directional and horizontal wells trajectory plans for Rumailaoilfield by selecting the suitable kick off point (KOP), build section, drop section andhorizontal profile. In addition to the optimized inclination and orientation which wasselected based on Rumaila oilfield geomechanics and wellbore stability analysis so that theoptimum trajectory could be drilled with minimum wellbore instability problems. The fourrecommended types of deviated wellbore trajectories include: Type I (also called Build andHold Trajectory or L shape) which target shallow to medium reservoirs with lowinclination (20o) and less than 500m step out, Type II (S shape) that can be used topenetrate far off reservoir vertically, Type III (also called Deep Kick off wells or J shape)these wells are similar to the L shape profile except the kickoff point is at a deeper depth,and design to reach far-off targets (>500m step out) with more than 30o inclination, andfinally Type IV (horizontal) that penetrates the reservoir horizontally at 90o. The study alsorecommended the suitable drilling mud density that can control wellbore failure for the fourtypes of wellbore trajectory.