bluuebunny/crossref_metadata_2025 huggingface dataset:
Anquiloglosia, enfoque multidisciplinario: serie de casos
Authors: JACOME OROZCO ALVARO LEON , Patiño Garnica Claudia Sildana , Brito Carlos
Published: May 2023

Introducción: la anquiloglosia (Ag) se define como un frenillo lingual en la base de la lengua que restringe el movimiento normal de la lengua. Su diagnóstico es importante, en los primeros días de vida, por las dificultades que puede generar para amamantar. Objetivo: presentar la experiencia de un servicio privado de consulta externa en el manejo de la Ag en pacientes recién nacidos en su primera consulta con un enfoque de protección a la lactancia materna. Materiales y métodos: estudio descriptivo de serie de casos. Se describe información demográfica de toda la cohorte de origen, así como detalles de evolución y seguimiento de los casos con Ag. Se incluye síntomas y clasificaciones con la prueba de Coryllos, la prueba de la Lengüita y la escala de Hazelbaker. Resultados: 32 pacientes recién nacidos presentaron Ag (15%)  de un total de 216. La distribución de edad, peso y sexo fue similar entre los grupos. 12 pacientes tenían antecedentes familiares de Ag (38%). Los síntomas en los casos con Ag fueron: dolor (84%), tanto en Ag anterior como posterior; grietas en los pezones (76%), predominando en Ag anterior; síndrome de Raynaud (72%) principalmente en pacientes con Ag anterior. 8 pacientes requirieron cirugía. La media de lactancia exclusiva para pacientes con Ag fue de 110 días (DS 58 días). Conclusiones: esta serie muestra el manejo de la Ag basado en la evolución que tenga la diada madre/hijo frente a la lactancia, basándose en diagnóstico físico y funcional. Esto permitió un mayor tiempo en lactancia exclusiva.
Meta-Analysis of the Association Between Atrial Fibrillation, Hypertension, Sleep-Disordered Breathing, and Wake-Up Stroke
Authors: Zhou Jin , Xu Jing , Cheng Aijuan , Kadier Yimiti , Liang Xiaoli , Mutailipu Maimaitijiang , Sun Shan
Published: May 2023

Background

The occurrence of atrial fibrillation, circadian fluctuation in blood pressure, and oxygen desaturation at night is likely associated with the pathophysiology of wake-up stroke. Whether patients who experience wake-up strokes are candidates for thrombolysis treatment is a serious dilemma. The aim is to investigate the association between risk factors and wake-up stroke and to determine variations that are associated with the pathophysiology of wake-up stroke.

Methods

Five major electronic databases were searched using a fitted search strategy to identify relevant studies. Odds ratios with 95% CIs were used to calculate estimates, and the Quality Assessment for Diagnostic Accuracy Studies-2 tool was used to conduct the assessment quality.

Results

A total of 29 studies were included in this meta-analysis. Hypertension is not associated with wake-up stroke (odds ratio, 1.14 [95% CI, 0.94–1.37]; P = .18). Atrial fibrillation is an independent risk factor to wake-up stroke, with a statistically significant difference (odds ratio, 1.28 [95% CI, 1.06–1.55]; P = .01). Subgroup analysis showed a different result in patients with sleep-disordered breathing, although no significant difference was assessed.

Conclusion

This study revealed that atrial fibrillation is an independent risk factor for wake-up stroke and that patients with atrial fibrillation who also experience sleep-disordered breathing tend to have fewer wake-up strokes.
The role of LMX and organizational climate in improving performance and effectiveness of local public administration: evidence from the Metropolis GZM
Authors: Marzec Izabela
Published: May 2023

Since the 1990s, along with the transformation of public administration and the emergence of new concepts of public management, the improvement of organisational effectiveness and performance (OEP) of local public administration has become an important goal of regional policies in many countries. The OEP of local public administration has started to be considered as an essential factor affecting the process of regional socio-economic development. However, to improve the performance of local public administration, factors influencing the OEP of public administration organizations need to be determined. Consequently, the purpose of this paper is to identify how such factors as the quality of relations between leaders and subordinates as well as learning climate influence the OEP of public administration organizations.

Method/approach: The paper presents the results of a survey research conducted among 153 employees of municipal offices in the Górnośląsko-Zagłębiowska Metropolis (i.e. Metropolis GZM). A model of relationships between LMX, organizational learning climate, and the OEP was examined with the use of Structural Equation Modeling and path analysis.

Findings: It was found that the LMX affected the OEP only indirectly through its impact on organizational learning climate which in turn influences the OEP. Therefore, the study also revealed that organizational learning climate mediated the relationship between the LMX and the OEP.

Originality: The presented results of the study have provided empirical evidence regarding the influence of LMX and organizational climate on the OEP of public organizations which was hitherto absent in the literature on the subject. A novel conclusion from this study is that the high quality of relationships between leaders and subordinates and organizational learning climate improve the OEP of local public administration organizations. Highly effective local public administration can become a driver of the regional development promoting new ideas, innovation and local incentives.
Wskaźnik ekspozycji widokowej jako narzędzie optymalizacji punktów widokowych – studium przypadku Szczebrzeszyńskiego Parku Krajobrazowego
Authors: Chmielewski Szymon , Grabowski Tadeusz
Published: May 2023

Punkty widokowe stanowią podstawowy zasób fizjonomiczny krajobrazu, umożliwiają obserwację panoram, a tym samym warunkują przepływ kulturowych usług ekosystemowych. Widok panoramiczny sam w sobie bywa celem podejmowanej aktywności turystycznej, stąd też funkcjonowanie punktów widokowych związane jest z siecią tras turystycznych. Optymalizacja sieci punktów widokowych jest więc kluczowa dla prawidłowego kształtowania funkcji turystycznej regionu oraz ochrony jego zasobów fizjonomicznych. Celem pracy jest metodyczna propozycja wskaźnika ekspozycji widokowej, będącego geoinformacyjnym narzędziem wspierającym proces wyznaczania i optymalizacji sieci punktów widokowych. Badanie przeprowadzono na przykładzie Szczebrzeszyńskiego Parku Krajobrazowego, w efekcie zaproponowano rozbudowę istniejącej sieci do 45 punktów. Wnioski wypływające z metody i jej ograniczenia omówiono w kontekście praktyki przygotowania operatów ochrony walorów krajobrazowych.
Detection of V. vulnificus septic shock with ARDS using mNGS
Authors: Dan Tangjun , Qin Haidong , Sun CaiZhi , Shen Hua , Guo Lei
Published: May 2023

The latest surveillance from the Centers for Disease Control and Prevention shows that the annual incidence of V. vulnificus infection is increasing. Unfortunately, in less well-known high-risk groups, this infection is usually excluded from differential diagnosis. Transmitted through wound exposure or ingestion, the mortality rate of foodborne diseases of V. vulnificus is the highest of all V. vulnificus. V. vulnificus is as lethal early diagnosis as Ebola and bubonic plague, so timely treatment is imperative. Sepsis caused by V. vulnificus infection mainly exists in the United States and is rarely reported in Southeast Asia. We report a 78-year-old man who went to the local hospital and complained of swelling in his right hand with severe pain. He ate raw salmon 2 days ago and denied other recognized seafood stab or trauma history and other seafood contact history. He was in septic shock at the time of treatment, so we immediately transferred to the emergency intensive care unit and tested for metagenomic next-generation sequencing (mNGS). The diagnosis was confirmed the second day after admission, and eventually he was cured and discharged from the hospital only after medical treatment, thus avoiding the risk of surgical debridement or even amputation. mNGS is helpful for early clinical diagnosis and effective early intervention for etiology, so that patients can get a good prognosis.
Molecular Epidemiology and the Control and Prevention of Cystic Echinococcosis in China: What is Known from Current Research
Authors: Wang Ying , Zhang Jing , Wang Xu , Ahmed Haroon , Shen Yujuan , Cao Jianping
Published: May 2023

As a zoonotic parasitic disease, echinococcosis is a severe global public health issue caused by the larvae of Echinococcus spp. Not only does echinococcosis threaten human health, but echinococcosis also causes enormous economic losses. China ranks first in the range of echinococcosis endemic areas, the number of infected patients, and the number of threatened populations worldwide, hence the most severe echinococcosis epidemic currently exists in China. Cystic echinococcosis (CE) is the most important form of echinococcosis. Accounting for nearly 80% of all echinococcosis cases, CE is the most important cause of the echinococcosis disease burden. Echinococcus granulosus sensu lato (s.l.) is the causative agent of CE and is considered a multi-genotype complex. The different genotypes of E. granulosus s.l. exhibit differences in morphology, transmission route, and epidemic characteristics. The corresponding clinical characteristics, clinical treatment, and vaccine responses also differ between the genotypes of E. granulosus s.l. During the past two decades, China has implemented echinococcosis control and prevention programs in endemic areas with impressive results. Specifically, the prevalence of echinococcosis has decreased. With such extraordinary achievements, precise control and prevention of the genotypes of E. granulosus s.l. have never been more important. Nevertheless, insufficient attention has been devoted to molecular epidemiology in the current control programs, and the lack of genotype data from humans and animal hosts exacerbates the situation. Hence, based on the ongoing control and surveillance programs, collecting additional molecular epidemiologic data and geographic information from humans and animals, as well as monitoring the clinical manifestations and drug and vaccine responses of the different genotypes, are invaluable for establishing a molecular epidemiologic database, which in turn can enhance the precise control and prevention of echinococcosis.
Pharmapolitics and the Early Roman Expansion: Gender, Slavery, and Ecology in 331 BCE
Authors: Peralta Dan-el Padilla
Published: May 2023

This article reinterprets an incident that Livy (8.18.4–11) and derivative later sources place in the year 331 BCE: a wave of poisonings whose perpetrators are brought to light after an enslaved woman contacts a Roman magistrate. Its main objectives are to show that the incident is best understood in connection with the transmission of novel—or perceived as novel—pharmacological knowledge, and in conjunction with shifts in the institution of slavery at Rome that were set in motion by the Republic’s expansion; that a key figure in the mythological encoding of this transmission was the legendary Circe; and that moving away from previous scholarship’s concern with the matronae alleged to have carried out the poisonings and focusing instead on “la servant délatrice” (Jean-Marie Pailler) opens up new corridors into the cultural history of this period.
STRUCTURAL AND FUNCTIONAL INTERDEPENDENCES OF BIOLOGICAL ORGANISMS IN EXTREME CONDITIONS
Authors:   Tychyny Uman State Pedagogical University, Ukraine, BELOSHITSKY P.V.
Published: May 2023

Investigations of the adaptation of living organisms/human body to various extreme factors are extremely important. Aim. To characterize and analyze the results of research of structural and functional interdependencies of organisms in extreme conditions. Methods. Comparative analysis of the registered biochemical, physiological characteristics of the body, mathematical modelling of underlying mechanisms on their basis, information and computer technologies. Results. Deviations of organisms’ functions during adaptation processes caused changes in some structures of organism. Significant role of quantitative and qualitative changes of the erythrocyte formation system in the reliability of organisms functioning in extreme conditions in highlands was confirmed. The changes in red and white blood cells reflected largely the relationships between the organisms’ reactivity and resistance. The dependences on degree of rarefaction of the air, mode of climbing, effects of athlete’s training, etc. were revealed. Adaptive hemolysis of erythrocytes, when the biologically active substances were released from blood cells and acted as messengers, were shown to be the triggers capable to change cell metabolism; they played significant roles in reliability of organisms functioning. The set of program models was developed. Results were applied successfully for training of athletes for high-altitude climbing. Conclusions. Results of the studies on the structural and functional interdependencies of organisms in extreme conditions were reviewed and analyzed. Results of mathematical modeling coincided with the results obtained in experiments and observations. In the process of adaptation to hypoxia human organism behaved likes an ultrastable system. Obtained results can be applied in practice.
Editor's Note
Authors:   School of Law of Edimburgo, Ithurria Benavente María Jesús , Morales Ortiz María Elisa ,   Universidad Austral de Chile
Published: May 2023

Editors' Note of Special Issue on Comparative Law
Procedural Aspects of the General Anti-Avoidance Rule. Comparative Analysis of the Cases of Chile and Spain
Authors:   Universidad Austral de Chile, Toledo-Zúñiga Patricia , Navarro-Schiappacasse María Pilar ,   Universidad de O´Higgins
Published: May 2023

Tax avoidance is a matter of worldwide concern, since it produces effects that impinge the proper functioning of any tax system. One of the strategies for fighting against tax avoidance is the establishment of a general anti-avoidance general rule (GAAR). This work is aimed at comparatively analyzing the procedural aspects of the Chilean GAAR and the Spanish GAAR, based on the similarities between their regulations, in order to benefit from the experience of the Spanish legislation, with achievements and shortcomings, for the complex legal activity that will entail the application of the GAAR in Chile.
Leave Policy System in Russia: Is It Time to Change?
Authors: Blednova Natalia D. , Bagirova Anna P.
Published: May 2023

As a demographic and family policy measure, the parental leave system is flexible in many countries. For example, parents can take full or partial leave, choose shorter leave with higher payments or vice versa; leave can be taken by other relatives of the child. In Russia, the labor legislation regulates only one of such flexible parameters—taking full or partial parental leave by not only the mother, but also the father or other relatives of the child. To study social attitudes towards the existing system of parental leave in Russia, we surveyed 506 male and 265 female employees of different organizations with and without children. To explore barriers in the system of the parental leave regulation, we carried out a content analysis of employees’ complaints published on the онлайнинспекция.рф website and analysed five cases of breaching parental leave regulations extracted from popular Russian mass media. Our results demonstrate discrepancies between the existing system of parental leave and respondents’ attitudes to its legal regulation. To address the problem, the system should be transformed to embrace flexibility. To foster the transformation, the government may promote conscious and responsible fatherhood and integrate the social institute of the labor market in the demographic policy.
Investigation of Antibacterial and Antifungal Efficacy of Zinc and Silver Nanoparticles Synthesized from Nasturtium officinale
Authors: ERCAN Leyla
Published: May 2023

Nanoparticles are nano-sized materials that can be widely used in fields such as medicine, pharmacology, and industry. The use of natural and easily available materials in nanoparticle synthesis is preferred because it is economical. Plants are extremely suitable for the synthesis of nanoparticles due to their natural and easy availability and the large number of components they contain with different properties. For this purpose, silver nanoparticles and zinc nanoparticles (AgNPs and ZnNPs), two different nanoparticles were synthesized from an edible plant, watercress (Nasturtium officinale). SEM (Scanning electron microscopy), SEM-EDX (Scanning electron microscopy-Energy dispersive X-ray), UV-VIS spectroscopy, XRD (X-ray crystallography), and FTIR (Fourier Transform Infrared Spectrophotometer) analyses of these nanoparticles were performed. In addition, the antimicrobial effects of these synthesized nanoparticles were determined by the disk diffusion method. As a result, nanoparticles obtained from Nasturtium officinale were effective on gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa), gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), and fungi (Candida albicans). In particular, AgNPs with broad-spectrum antimicrobial activity were obtained from the watercress. While ZnNPs showed inhibition effects of 49% on K. pneumoniae, 51% on S. aureus, and 62% on C. albicans, AgNPs showed inhibition effects of 93% on P. aeruginosa, 87% on S. aureus, 81% on E. coli, 80% on C. albicans, 72% on K. pneumoniae, and 56% on S. pyogenes. Thus, it has been shown that Nasturtium officinale can be used effectively in the production of new biotechnological products, especially with antimicrobial properties.
Allium cepa-based zinc oxide nanoparticles: characterization and biochemical potentials
Authors: Masud Sheeza , Munir Hira , Irfan Muhammad , Tayyab Muhammad
Published: May 2023

In this research work, Allium cepa (AC)-bulb-based zinc oxide nanoparticles (ZnO-NPs) were prepared successfully through a green synthesis approach. Phytocompounds present in the AC bulb successfully reduced and stabilized zinc (II) (Zn2+) ions into ZnO-NPs. Syntheses of the liquid form (L-ZnO-NPs) and calcined form (C-ZnO-NPs) were carried out. The color change of the nanoparticle (NP) colloidal solution from transparent to yellow, the surface plasmon resonance peaks by ultraviolet–visible spectroscopic analyses at 350 and 370 nm and the infrared spectrum showing functional groups below 700 nm confirmed the synthesis of ZnO-NPs. The elemental composition of NPs revealed that the weight percentage of zinc was 66 and 61%, while that of oxygen was 24 and 26% in C-ZnO-NPs and L-ZnO-NPs respectively. The scanning electron microscopy and X-ray diffraction pattern confirmed the successful synthesis of rod-shaped, crystalline ZnO-NPs (30–35 nm) with a uniform distribution. The 2,2-diphenyl-1-picrylhydrazyl-assay-based antioxidant potentials of C-ZnO-NPs and L-ZnO-NPs were recorded as 72 and 65% inhibition, respectively, while the hydrogen peroxide (H2O2) radical-scavenging assays revealed 62 and 48% inhibition, respectively, at a 75 μl concentration. ZnO-NPs showed good antimicrobial, in vitro antidiabetic and antioxidant potential. Hence, AC-bulb-based ZnO-NPs synthesized through a green chemistry approach can be considered an innovative addition to the science of free radical scavenging, diabetes and microbial infection management.
An investigation of corrosion in dehumidification bubble caps in a gas refinery
Authors: Mohammadzadeh Hurieh , Jafari Robabeh , Gheysvand Abolfazl
Published: May 2023

One of the severe challenges in the oil, gas and petrochemical industry is associated with reducing the costs of corrosion damages by removing oil fluid moisture and humidity in facilities. An essential component of moisture absorption towers in the dehumidification section is the bubble cap, which loses its efficiency in a short time due to continuous contact with steam. In the present work, the causes of the destruction of a piece of bubble cap were investigated thoroughly by employing visual and microstructural observation, chemical composition study using a quantometer, energy-dispersive X-ray spectroscopy and X-ray diffraction assessments and corrosion behavior study by polarization and electrochemical impedance spectrometry analysis. The mechanism and type of corrosion that occurred in the bubble cap and its capability against the corrosion were assessed. The results showed that the corrosion products after service were iron (II,III) oxide (Fe3O4), iron (III) oxide (Fe2O3), iron (III) hydroxide (Fe(OH)3) and iron (II) carbonate (FeCO3), which decreased the microhardness from 121.3 to 99.3 HV. The corrosion rate was found to be 0.03116 mm/year in saline solution. The poor performance of the material against corrosion was attributed to casting defects and ineffective microstructural phases, formed due to deficient alloying elements. According to the results, some recommendations and solutions, as effective preventive ways, are proposed to hinder corrosion and lead to higher durability and lower replacement costs.
Aseptic Osteonecrosis of the Femoral Head in Children Living with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease of Brazzaville, Congo
Authors: FO Galiba Atipo-Tsiba , ASW Bilongo-Bouyou , BM Gatsongui , LO Ngolet , N Osseke , F Malanda , A Elira Dockekias
Published: May 2023

Introduction: Aseptic Osteonecrosis of the Femoral Head (AOFH) is a degenerative complication of sickle cell disease. In the absence of care, it is a source of disability through painful lameness and functional impotence that it causes over time. Its data in african children are scarce. This work aimed at determining its prevalence and describing its characteristics. Methodology: It was about a descriptive study conducted over a4 years- period at the CNRDr on children suffering from homozygous sickle cell disease and presenting with ONFH. The studied variables were epidemiological, clinical and paraclinical, collected from medical records. The Postel Merle-d’Aubigné functional score was used to assess the functional status of the hips and the Arlet and Ficat classification for radiological staging. Results: The study involved 31 children (18 boys and 13 girls). The prevalence of AOFH was 2.15%. The average age was 11.51 ± 2.17 years old. Almost half were under 11 (45.16%). At diagnosis, the damage was bilateral in 10/31 cases, bringing the number of pathological hips to 41/62. Hip pain was constant and associated with lameness in 83.87% of cases. Hip function was good, fair, and poor respectively in 41.94%, 54.84% and 3.22% of cases. One child presented with two stiff hips. Radiologically, stages I and II on one hand and III and IV on the other hand of Arlet and Ficat were respectively found in 45.16% and 54.84% of cases. Conclusion: We report one of the most important series of black Africa. AOFH affects young children. The diagnosis is frequently late, made at the stage of functional impotence with joint destruction. The search for predictive factors is important to improve the prognosis of these young patients.
Causes and Prospects of SCFI Fluctuations During the COVID Period
Authors:   The Korea International Trade Research Institute, Ha Young-Kyou , Woo Su-Han
Published: May 2023

Purpose – It is very important to forecast and analyze the shipping market in business operation and national policy establishment. However, it has become very difficult to forecast the shipping market cycle after COVID based on the balance of supply and demand as before. It is necessary to analyze this in a new way. Design/Methodology/Approach – In this study, we try to examine the relationship with freight using a new variable in a situation where traditional analysis is impossible. The basic analysis method of this study is panel regression analysis. In the basic formula, the COVID dummy variable was added to the independent variables, and the main variables and interaction terms were created to analyze the effect of economic indicators on shipping costs in the COVID situation. Findings – As a result of analyzing the impact of economic indicators on shipping costs after COVID, it was found that PPI and the Demand Forecasting Index had a negative effect on shipping costs. This is contrary to previous studies which found that shipping costs increase in proportion to economic growth or trade volume. However, economic instability increases the inflation index and the value of goods, and when inflation reaches its peak, the value of goods falls. Research Implications – This study is meaningful in that it analyzes the impact of the current situation on shipping costs, which may be difficult to analyze, and suggests the possibility of predictive research. If we apply this analysis and variables to predictive research, we will be able to derive meaningful results.
Emergence of ChatGPT and Changes of Marketing: Early Study of Internet Buzz on ChatGPT
Authors:   The Korea International Trade Research Institute, Lee Won-Jun
Published: May 2023

Purpose – The purpose of this study is to examine the changes and characteristics of artificial intelligence, chatbots, and ChatGPT, and to explore their future implications. Additionally, this research aims to provide insights by analyzing the initial internet buzz surrounding ChatGPT. Design/Methodology/Approach – This study conducted theoretical analysis based on previous research on ChatGPT. The past engineering discussion on ChatGPT has been converted into a management discussion. In addition, big data related to ChatGPT mentioned in internet news, blogs, and other sources were collected through web crawling, and 2-gram analysis, word cloud analysis, and sentiment analysis were performed on the collected data. Findings – Internet users have formed topics about ChatGPT related to artificial intelligence, chatbots, open services, use, services, questions, and technology. In addition, emotions related to ChatGPT are more positively oriented, such as innovation, usefulness, and naturalness, compared to negative emotions. These results mean that consumers are favorable to ChatGPT and expect changes that artificial intelligence will bring. Research Implications – The findings of this study suggest that consumers are highly interested in ChatGPT and are prepared to accept new innovations. This findings indicate that related services such as artificial intelligence and ChatGPT will become major academic and practical marketing issues in the future.
The Effect of PPL Exposure of Innovative Products on Attitude toward a Product: Focusing on the Mediating Effect of Perceived Curiosity
Authors:   The Korea International Trade Research Institute, Lee Sinae , Min Dongwon
Published: May 2023

Purpose – The purpose of this study is to verify the effect of PPL exposure to innovative new products on attitude based on data from actual companies. Design/Methodology/Approach – This study explored the mediating effect of perceived curiosity in the effect of the PPL exposure of innovative new products on product attitudes targeting 142 actual innovative product buyers. To this end, bootstrapping was performed based on Hayes' PROCESS macro. Findings – The PPL exposure of innovative products causes consumers to form positive product attitudes, and there was perceived curiosity at the base. Research Implications – The PPL exposure group examined in this study led them to have a positive product attitude toward innovative products. The reason for this is as follows. Most innovative products are unfamiliar or untrustworthy. Therefore, the acquisition of knowledge or information about the product has an important effect on product attitude. The PPL exposure examined in this study aroused perceived curiosity in consumers, which led them to explore more information, thereby reducing the risk of innovative products. Pre-generated awareness as a control variable in this process did not affect perceived curiosity. This means that company or brand awareness is not important for exposure through PPL to lead consumers to a positive attitude.
Discourse, Deliberation and Difference in an Authoritarian Public Sphere
Authors: Hasmath Reza
Published: May 2023

This article explores how discourse, deliberation and difference – classically advanced by Jurgen Habermas and Iris Marion Young within a Western democratic context – functions in an authoritarian environment, with special reference to China. The article suggests why authoritarian discourse and deliberation is more limited than its Western democratic counterparts. It further suggests that the incorporation of difference into authoritarian discourse and deliberation is difficult due to the inherent tensions between the ‘Other’ and the ruling elite in authoritarian polities. Nevertheless, these constraints do not invalidate the notion that discourse and deliberation is theoretically possible and has a practical function in authoritarian regimes.
Use of various research methods in forensic practice to determine lifetime and age of injury: A review
Authors: Frolova Olga О. , Zabozlaev Fedor Georgievich , Klevno Vladimir A.
Published: May 2023

From the 19th century to the present, forensic physicians have been interested in the subject of damage formation prescription. After reviewing the literature on the problem of traumatic hemorrhage prescription, it is clear that there is no single position, approach to the study of this issue, or an unambiguous time frame that accurately determines the period from injury to the victims death. Forensic doctors in the 19th and 21st centuries initially focused on the macroscopic picture of the injury, followed by microscopic examination. When studying micropreparations, they are guided by the cellular composition of the hemorrhage, based on previously known data, their own experience and knowledge in this field, the brief circumstances of the incident (if any are indicated in the direction of forensic histological examination), and the victims age. Researchers have determined approximations and developed approximate time frames for the formation of damage throughout the years, now taking into account the above characteristics and the victims condition during and after the injury, with the acquired experience and accumulated knowledge. However, scientists have not come to a consensus. Medicine, achievements, progress, and perseverance of scientists strive forward, involving related sciences in the study of antiquity. As a result, methods, such as molecular genetics, biophysical, biochemical, and immunohistochemical, have found use, allowing researchers to analyze cellular composition and enzymatic and hormonal changes in damaged tissues. Ultrasound is one of the instrumental methods being developed. This problem remains completely unresolved when both laboratory and instrumental methods and their combination are used.
Two components of the forensic assessment process and severity of nonlife-threatening local musculoskeletal injuries: a review of the article “Controversial issues of the use of medical criteria ‘persistent loss of general working capacity’ in determining the severity of harm caused to human health”
Authors: Kulikov Sergey N.
Published: May 2023

In the article, the doctrine of denying a forensic medical assessment of the severity of local injuries of the musculoskeletal system, which are not life-threatening, is considered from a critical position, based on an interdisciplinary approach, without considering the influence of medical care. The article shows the inconsistency, still present among some forensic physicians, of the opinion that determining the severity of harm to health by causing nonlife-threatening injuries without the fact of a determined outcome is allegedly expressed in violation of the basic provisions of the Criminal Code of the Russian Federation. In the context of the topic, the author reasonably points to the two-component essence of the definition of clause 6.11, 194th order of the Ministry of Health and Social Development of Russia of 2008, dated April 24, 2008, N 194n On approval of medical criteria for determining the severity of harm caused to human health. The fundamental explanatory provisions of the conceptual construction of the wording of clause 6.11 are provided in criminal law and medical relations. The author showed that there were no inconsistencies between these components. The presence of a list of medical criteria for harm to health of a similar direction, as in the existing paragraph 6.11, demonstrates the objective need in the updated version of the draft order of the Ministry of Health of Russia On approval of the procedure for determining the severity of harm caused to human health.
In response to the subject of forensic diagnosis of a human death caused by exposure to low-temperature water
Authors: Chudakov Alexander Y. , Tolmachev Igor A. , Khrustaleva Yulia A. , Bozhchenko Alexander P.
Published: May 2023

BACKGROUND: Examining corpses recovered from the water often poses challenges in forensic medical evaluation.
AIM: To propose a clarifying set of differential diagnostic features characteristic of a fatal cold injury in low-water temperature conditions.
MATERIALS AND METHODS: Clinical observations, forensic examination of the corpses of patients who died from general hypothermia and drowning in ice water.
RESULTS: A complex of the most apparent diagnostic signs for the differential diagnosis of acute deep hypothermia in water from other types of hypothermia and drowning was revealed.
CONCLUSION: Morphofunctional changes in the internal organs have always been determined by hypothermias type, degree, and speed. The most characteristic signs of a fatal cold injury in low-water temperature conditions were determined by the state of the blood supply and the structure of organs and tissues. Pathological changes developed according to the type of edema, focal ischemia, and focal necrosis.
Topical issues of surgical treatment of pelvic floor dysfunction. A literature review
Authors: Bezhenar Vitaly F. , Plekhanov Andrey N. , Bezhenar Fedor V. , Epifanova Tatiana A.
Published: May 2023

This article presents a review of the current literature on the problem of omission and prolapse of the internal genitalia in women. Patients diagnosed with pelvic organ prolapse need pelvic floor plastic surgery. Currently, in spite of the extensive experience in managing this category of patients, there is still no single and unambiguous approach to the choice of surgical treatment tactics.
This review describes the latest information on the etiopathogenesis of pelvic floor supporting apparatus lesions, namely, systemic connective tissue dysplasia as the main development factor. Prospective development of genetic and immunohistochemical marker diagnosis is the key to individual selection of treatment options for this multidisciplinary problem. The results of interventions are characterized by extreme variability in terms of both effectiveness and the frequency of intra- and postoperative complications. The treatment of rare forms of prolapse after surgery for rectal cancer also raises many questions. The current multitude of types of surgical interventions for genital prolapse and variants of pelvic floor defect closure is constantly being modified. To date, there is no universal treatment option, and all available techniques have both advantages and disadvantages, as well as limited application due to the risk of somatic complications, high recurrence rate, and the need for expensive equipment and a highly qualified surgeon.
New research is needed, taking into account the current knowledge about the cellular and molecular mechanism of the lesion of the pelvic floor supporting apparatus. All of this will improve the methods of correction of pelvic organ prolapse in both typical and rare forms caused by iatrogenic factors. As a result, this may lead to an improvement in the quality of life of such patients.
In memory of Nikolay Alexandrovich Sosnin, a pioneer of endoscopic operative gynecology in the Arkhangelsk region (to the 70th anniversary of his birth and the 100th anniversary of N.A. Semashko Northern Medical Clinical Center, Arkhangelsk, Russia)
Authors: Andreeva Anna V. , Baranov Alexey N. , Kazakevich Elena V. , Kozyr Oleg F. , Samburov Gleb O. , Tuchina Tamara A. , Dyachkov Sergey K.
Published: May 2023

This article presents information about Nikolay Alexandrovich Sosnin, a pioneer of endoscopic operative gynecology in the Arkhangelsk region. On March 10, 2022, he would have turned 70 years old. For more than 30 years, he was the head of the gynecological department of N.A. Semashko Northern Medical Clinical Center (Arkhangelsk, Russia). N.A. Sosnin introduced laparoscopic technology into the practice of gynecologists in the Arkhangelsk region.
Exploring Allelic Differences in KRAS Mutant CRC
Authors:   , Budagyan Konstantin , Chernoff Jonathan
Published: May 2023

Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and are associated with poor prognosis and resistance to therapy. There is a substantial diversity of KRAS mutant alleles observed in CRC. Emerging clinical and experimental analysis of common KRAS mutations suggest that each mutation differently influences the clinical properties of a disease and response to therapy. Although there is some evidence to suggest biological differences between mutant KRAS alleles, these are yet to be fully elucidated. One approach to study allelic variation involves the use of isogenic cell lines that express different endogenous Kras mutants. Here, we generated Kras isogenic Apc-/- mouse colon epithelial cell lines using CRISPR-driven genome editing by altering the original G12D Kras allele to G12V, G12R, or G13D. We utilized these cell lines to perform transcriptomic and proteomic analysis to compare different signaling properties between these mutants. Both screens indicate significant differences in pathways relating to cholesterol and lipid regulation. We found that these processes are upregulated in G12V lines through increased expression of nuclear SREBP1 and higher activation of mTORC1. G12V cells showed higher expression of ACSS2 and ACSS2 inhibition sensitized G12V cells to MEK inhibition. Finally, we found that ACSS2 plays a crucial role early in the development of G12V mutant tumors, in contrast to G12D mutant tumors. These observations highlight differences between KRAS mutant cell lines in their signaling properties. Further exploration of these pathways may prove to be valuable for understanding how specific KRAS mutants function, and identification of novel therapeutic opportunities in CRC.
ÖZEL GÜVENLİK VE KORUMA ÖN LİSANS PROGRAMI İÇİN DURUM DEĞERLENDİRMESİ: EĞİTİM SÜRECİ VE İSTİHDAMI
Authors: Yağcı Ali
Published: May 2023

Özel güvenlik ve koruma ön lisans programlarının yaygınlaşması ile güvenlik sektörünün ihtiyaç duyduğu nitelikli güvenlik görevlisini akademik eğitimlerle destekleyerek globalleşen dünyanın güvenlik ihtiyaçlarına cevap verebilecek donanımlarına sahip personeller yetiştirilmektedir. Özel güvenlik ve koruma programı mezunları özel ve kamu alanlarında istihdam edilmektedir. Mezunlarının kamu kurumlarında çalışabilmeleri için “Kamu Personeli Seçme Sınavı (KPSS) Ön Lisans” puanı gerekmektedir. Araştırmanın amacı; 2016 yılından 2022 yılına kadar, özel güvenlik ve koruma programındaki öğrenci sayıları, mezun sayıları ve kamu alanlarında açılan kadro sayıları analiz edilerek kamuya yerleşme oranları bazında durum değerlendirmesi yapılmıştır. Araştırma sonucunda; 2016 yılından 2022 yılına kadar, özel güvenlik ve koruma programdan mezun sayısının çok fazla olmasına karşın, bu alanda yapılan atama sayısının oldukça yetersiz olduğu tespit edilmiştir. Özel güvenlik ve koruma programdan mezun olan erkeklerin “Koruma ve Güvenlik Görevlisi” unvanı ile kamuya atanma olasılığı genel toplamda %2.3’dür. Kadın mezunların ise “Koruma ve Güvenlik Görevlisi” unvanı ile kadrosu ayrılmadığından kamuya atanma olasılığı mevcut değildir.
Внеурочный технологический курс «Вселенная анимации» как средство профессионального самоопределения обучающихся
Authors: Черепова В.А. , Соловьева И.Б.
Published: May 2023

В статье раскрывается сущность понятия профессиональное самоопределение. Рассматривается возможность реализации профессионального самоопределения обучающихся в рамках предмета «Технология». Представлен авторский технологический курс «Вселенная анимации» для знакомства и погружения обучающихся в профессии сфер кинематографа и анимации, актуальные на российском рынке труда и популярные среди молодежи. Курс позволяет не только закрепить и углубить знания по предмету «Технология» и узнать о новых профессиях (художник-аниматор, мультипликатор, сценарист, художник-постановщик, моушндизайнер), но и освоить различные технологии съемки и редактирования двумерных анимационных роликов в графическом редакторе Open Toonz.
Психологические особенности влияния гаджетов на поведение ребенка
Authors: Агирбова Д.М. , Тхакохова К.Н.
Published: May 2023

В научной работе рассматривается вопрос влияния гаджетов на поведенческую модель ребенка. Приводится статистические данные международных исследований и опытов, также личных наблюдений по определению психологических особенностей влияния гаджетов на развитие ребенка.
Factors Influencing Purchase Intention toward Thai Traditional Medicine in Chanthaburi, Thailand
Authors: Piyathaworn-anan Smita , Nuangjamnong Chompu
Published: May 2023

The purpose of this research is to obtain a deeper understanding about purchase intention of herb for consumption and actual physiological wellbeing towards Thai traditional medicine in Chanthaburi, Thailand. This research used Simple Linear Regression and Multiple Linear Regression. The independent variables of the study consist of attitude, health consciousness, perceived value, herb knowledge, herb safety concern, perceived consumer effectiveness, and purchase intention of herb for consumption. The dependent variables include purchase intention of herb for consumption and actual physiological wellbeing. The questionnaire was spread out via online There were 385 respondents, collecting adopting convenience sampling and snowball sampling. The findings of this study showed that five out of six of the independent variables significantly affect purchase intention of herb for consumption, which are perceived consumer effectiveness, herb knowledge, attitude, health consciousness, and herb safety concern, excluding perceived value. Moreover, purchase intention of herb for consumption significantly influence actual physiological wellbeing. There are some limitations in this research such as limitations of online survey, target respondents, time and there is few research about Thai traditional medicine that study on purchase intention of herb for consumption. The research is about the important variables that influence purchase intention of herb for consumption and actual physiological wellbeing.
Deneysel Ahşap Koruma Uygulamasında Numune Hazırlama İşlemleri ve Metodik Düzenlemelerin İstatistiki Yönden Değerlendirilmesi
Authors: USTA İlker
Published: May 2023

İstatistiksel değerlendirme, deneysel araştırmalar önde gelmek üzere, gözlem ve ölçüm ile elde edilen nicel ve nitel verilere dayalı tüm araştırmaların merkezinde yer alan ve evrensel kabullere yaslanan kuramlarla pekiştirilmiş matematiksel formülasyon eşliğinde gerçekleştirilen muhtevalı bir inceleme faaliyeti olup bütün disiplinlerle bütünleşik halde, bir problemin açıklığa kavuşturulmasına dayanak teşkil eden yöntemler vasıtasıyla, karşılaştırılabilir sonuçlara ulaşmak için yürütülen bir süreçtir. Bu perspektifte, bilimsel çalışmalarda istatistiksel düşüncenin önemine temellenmiş bu çalışma, deneysel araştırma sonuçlarının istatistiki bakış açısıyla değerlendirilerek çıkarımlar yapılmasını örneklendirmeyi amaçlamaktadır. Bu çalışmada, ahşap koruma (emprenye) alanında yapılması öngörülen bir deneysel uygulama öncesinde, numune hazırlama ve metodik düzenlemelere ilişkin olarak mevzubahis olan bazı konular, örnek bir problem dahilinde “numune boyutlarının normalliğinin belirlenmesi, yüzey örtme uygulamasına yönelik hipotezlerin test edilmesi, koruyucu emprenye maddesi çözelti konsantrasyonlarının varyans çözümlemesinin yapılması, sıvı ve kuru haldeki koruyucu madde absorpsiyonlarının regresyon denkleminin oluşturularak korelasyon katsayısının tespit edilmesi” temaları dahilinde, elle yapılan hesaplamalarla sıralı bir süreç olarak istatistiksel bakımdan incelenerek ortaya koyulmuş ve neden-sonuç ilişkisi zemininde kapsamlıca değerlendirilerek açıklanmıştır.
Dve desetletji dinamike podjetniškega razvoja: GEM Slovenija 2022
Authors: Širec Karin , Crnogaj Katja
Published: May 2023

Raziskava GEM ponuja poglobljeno analizo različnih družbenih, kulturnih, političnih in ekonomskih dejavnikov, ki vplivajo na podjetniško okolje in podjetniško aktivnost, ter predstavlja celovit okvir za razumevanje nacionalnih podjetniških razmer. Ti dejavniki imajo ključno vlogo pri oblikovanju podjetniških ambicij posameznikov in uspešnosti ustanavljanja ter delovanja podjetij. Raziskava s tem zagotavlja neprimerljiv vpogled v nacionalno podjetništvo in njegove značilnosti ter presega informacije, ki so na voljo v drugih statističnih virih. Raziskava namreč vključuje tudi odnos posameznikov in družbe do podjetništva ter želje in usposobljenost ljudi za podjetništvo, v vseh fazah podjetniškega procesa. S proučevanjem teh vidikov v različnih državah, GEM ugotavlja ključna gonila in ovire za podjetništvo, kar zainteresiranim stranem omogoča, da razvijajo podporni podjetniški ekosistem. Najnovejše poročilo je posebno, saj vključuje retrospektivo zadnjih dveh desetletij. V tem obdobju je slovensko podjetništvo doživelo pomembne spremembe, od spodbujanja inovacij in razvoja zagonskih podjetij, do izzivov povezanih z gospodarskimi krizami.
Settlement studies on Orłów County until the 16th century: Territorial and administrative past. settlement landscape. and ownership relations
Authors: Ćwikła Łukasz
Published: May 2023

The book presents the territorial-administrative past, the settlement landscape, and the ownership structure in the area of former Orłów County until the 16th century. On the basis of the so far unexplored manuscript sources from the Central Archives of Historical Records in Warsaw, and the records of the metropolitan chapter in Gniezno, the landscape of medieval settlement in Orłów County has been reconstructed and the estates of the most important local noble families have been discussed. In the course of the research, it was possible to identify new settlement sites and shift the metrics of some of them. The annexes include a list of all identifiable settlement points and genealogical tables. The iconographic section and the geographical index also constitute an important element of the publication.
A bienal de 1961: a atuação de Mário Pedrosa
Authors:   Universidade de São Paulo, Hoffmann Ana Maria Pimenta
Published: May 2023

Há 50 anos, a Bienal comemorava 10 anos de existência com uma mostra de grande proporções e com a direção artística do crítico de arte Mario Pedrosa. Esta VI Bienal do Museu de Arte Moderna de São Paulo realizou-se entre 1º de outubro e 31 de dezembro de 1961, no Pavilhão das Nações. Nesta minha comunicação, eu gostaria de analisar o projeto desta Bienal, sua significação nos contextos das Bienais organizadas pelo MAM SP, do processo de independização administrativa da mostra e na afirmação de um modelo de direção artística em muitos aspectos atravessou estes 60 anos de Bienais.