bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation and change in the formal marking of Khotanese I
Authors: Del Tomba Alessandro
Published: October 2022

In Khotanese, masculine nominals of the a-declension tend to lose the formal distinction between nominative singular -ä and genitive-dative singular -i. Likewise, the diphthongs ei and ai interchange freely in post-archaic Old Khotanese not only within but also at the end of a word, thus eliminating the distinction between nominative singular -ei and genitive-dative singular -ai of the secondary aa-declension. The aim of this article is to investigate the strategies of formal marking that arose in post-archaic texts in order to differentiate the genitive-dative from the nominative, applying morphological and syntactic criteria.
Mesoporous biophotonic carbon spheres with tunable curvature for intelligent drug delivery
Authors: Fu Jianye , Hui Tiankun , An Dong , Shan Wei , Chen Guobo , Wageh Swelm , Al-Hartomy Omar A. , Zhang Bin , Xie Ni , Nie Guohui , Jiao Jinqing , Qiu Meng , Zhang Han
Published: October 2022

Mesoporous carbon spheres (MCSs) are widely used in the field of pollutants adsorption, energy storage and various biomedicine applications such as targeted delivery vector, phototherapy sensitizers, bioimaging contrast agents, etc. Current synthetic strategies including soft templating and hard templating methods generally have the limits of using expensive surfactants or lack of control over the pore structures. Therefore, the complex and uncontrollable pore structures limit its further clinical application. Herein, we proposed a new synthetic strategy to control the uniformity of pore channel arrangement in MCSs which can modulate the photonic property and the corresponding light controlled drug release property in intelligent drug delivery. The as obtained MCSs with relative uniform pore channel arrangement and long pore channels are demonstrated to have the best NIR light-induced drug release performance. This work provides not only new synthetic method to modulate pore structure characteristics and biophotonic property of MCSs, but also uniform MCSs as novel delivery platforms with advanced controlled release performance.
The Visual Rhetoric of Monty Python’s Flying Circus: Fulfilling Noël Carroll’s Hopes for a Classification of Sight Gags
Authors: Baruchello Giorgio
Published: October 2022

In his 1990s studies of visual humor, Noël Carroll left to “future researchers” the laborious task of developing a “comprehensive and rigorous classification of the phenomena” pertaining to “the sight gag.” Carroll contributed five possible items belonging to such a taxonomy, i. e., “the mutual interference gag” (e. g., a character’s perspective vs the viewer’s one), “mimed metaphors” (e. g., Chaplin’s bread rolls as dancing feet), “the object analog” (e. g., a tuba used as an umbrella), “the switch image” (i. e., reinterpretations forced by montage) and “the solution gag” (e. g., the character’s inventiveness surprises the viewer). Following the implicit reference to rhetoric built in the very names of some of these items, this article shows how the well-established tropes of classical rhetoric, indeed three hundred of them, can be employed, with a modicum of analogical creativity, in order to address the visual component of comedic sketches, as exemplified by Monty Python’s famous Flying Circus.
On monotone Markov chains and properties of monotone matrix roots
Authors: Guerry Marie-Anne
Published: October 2022

Monotone matrices are stochastic matrices that satisfy the monotonicity conditions as introduced by Daley in 1968. Monotone Markov chains are useful in modeling phenomena in several areas. Most previous work examines the embedding problem for Markov chains within the entire set of stochastic transition matrices, and only a few studies focus on the embeddability within a specific subset of stochastic matrices. This article examines the embedding in a discrete-time monotone Markov chain, i.e., the existence of monotone matrix roots. Monotone matrix roots of

(

2
×
2

)

\left(2\times 2)

monotone matrices are investigated in previous work. For

(

3
×
3

)

\left(3\times 3)

monotone matrices, this article proves properties that are useful in studying the existence of monotone roots. Furthermore, we demonstrate that all

(

3
×
3

)

\left(3\times 3)

monotone matrices with positive eigenvalues have an

m

m

th root that satisfies the monotonicity conditions (for all values

m
∈
N
,
m
≥
2

m\in {\mathbb{N}},m\ge 2

). For monotone matrices of order

n
>
3

n\gt 3

, diverse scenarios regarding the matrix roots are pointed out, and interesting properties are discussed for block diagonal and diagonalizable monotone matrices.
Pactuação interfederativa de óbito por causa definida com relação à Atenção Básica em Santa Catarina
Authors: Da Silva de Souza Sabrina , Da Cunha Ana Cláudia , Rabelo Suplici Samara Eliane , Maris Zamprogna Katheri , Prim Laurindo Dione Lúcia
Published: October 2022

Objetivo: avaliar o alcance do indicador de pactuação interfederativa na proporção de registro de óbitos por causa básica definida nos municípios de Santa Catarina e sua relação com a cobertura de Atenção Básica e de Estratégia de Saúde da Família. Método: estudo ecológico, desenvolvido por meio da técnica de análise espacial, com 295 municípios do Estado de Santa Catarina, e dos registros de relacionamento probabilístico. Resultados: as variáveis não apresentaram correlação significativa. Outrossim, a meta de 97% pactuada para este indicador, no estado de Santa Catarina, entre 2017 (96%) e 2018 (95%) não foi alcançada. Conclusões: não houve influência da cobertura de Atenção Básica e Estratégia de Saúde da Família sobre o indicador proporção de óbitos por causa básica definida.
Saúde mental na segunda onda da pandemia de Coronavirus Disease 2019 no Brasil*
Authors: De Miranda Ramos Mozer , Cerqueira-Santos Elder , De Oliveira Machado Rodrigo
Published: October 2022

Objetivo: identificar preditores de distress e fadiga em brasileiros na segunda onda de Coronavirus Disease 2019, observando marcadores político-identitários. Método: foi realizado um survey online com 1.328 respondentes brasileiros, com questionário socio-identitário, questionários sobre efeitos psicossociais da pandemia e escalas padronizadas para avaliar distress, fadiga, autoritarismo e conservadorismo. Resultados: foram encontradas diferenças significativas (através de análise de variância e testes t) acerca da saúde mental com relação a orientação sexual, gênero, identificação étnico-racial, orientação política, autoritarismo, conservadorismo, importância dada à religiosidade e tamanho da cidade de moradia. As regressões lineares realizadas destacaram que os problemas associados a pandemia, como uso de substâncias psicoativas e problemas com o peso, desempenham papel importante para saúde mental, juntamente com a afetação emocional provocada pela pandemia. Conclusões: os problemas associados à pandemia, a afetação emocional e os marcadores político-identitários são fundamentais para a compreensão e atuação acerca da saúde mental da população nesse contexto.
Infarto agudo do miocárdio recorrente sob a perspectiva do paciente
Authors: Rosa Soares Junior Joaquim , Almeida Sudré Graciano , De Almeida Corrêa Carla Regina , Rocha Siqueira Sudré Mayara , Naves Carrijo Marcos Vítor , Marosti Dessotte Carina Aparecida , Rodrigues de Oliveira Maier Suellen
Published: October 2022

Objetivo: compreender o infarto agudo do miocárdio recorrente sob a perspectiva da pessoa que vivenciou o evento isquêmico. Método: pesquisa qualitativa descritiva-exploratória, que utilizou os preceitos teóricos e metodológicos da pesquisa convergente assistencial. Os participantes do estudo foram pessoas com diagnóstico de infarto agudo do miocárdio recorrente, admitidas em um hospital do sul de Mato Grosso. Os dados foram coletados por meio de entrevistas semiestruturadas, sendo estas transcritas, codificadas e posteriormente organizadas com o uso de um software de acesso livre. Resultados: evidenciou-se a descontinuidade das ações de cuidado após o primeiro evento isquêmico e a escassez de orientações oferecidas para pessoa e aos seus familiares na alta hospitalar. Conclusões: foi possível compreender que a pessoa que vivenciou o infarto do miocárdio recorrente se responsabiliza, referindo à falta de atitudes individuais para mudança em relação ao evento anterior, fator que julgam contribuir para o segundo evento isquêmico.
Perfil de letramento em saúde de portadores de doença renal crônica em tratamento pré-dialítico
Authors: Avelar Oliveira Gabriela Katrinny , Lima Moraes Katarinne , Alves Caetano Thaynara , Carvalho Gonçalves dos Santos Débora , Mendes Mendes de Oliveira Thaís , Borges Cristiane José
Published: October 2022

Objetivo: descrever as condições de letramento em saúde de portadores de doença renal crônica em tratamento pré-dialítico. Método: estudo transversal, realizado com 41 portadores de doença renal crônica em tratamento pré-dialítico em acompanhamento ambulatorial, nos meses de janeiro a julho de 2019. Nas entrevistas foi aplicada a versão brasileira do questionário Health Literacy Questionnaire e um questionário sociodemográfico e clínico. Estatística descritiva foi utilizada para análise dos dados. Resultados: os participantes tiveram menor desempenho nas escalas - informações suficientes para administrar minha saúde e capacidade de encontrar boas informações sobre saúde. E melhores desempenhos encontrados foram no apoio social e na capacidade de se envolver ativamente com os profissionais de saúde. Conclusão: o estudo fornece uma análise mais complexa dos pontos fortes e limitações relacionadas ao letramento em saúde de portadores de doença renal nos estágios iniciais, complemento importante para o campo do cuidado dessa população.
Concepções e práticas sobre percurso da formação em saúde mental do enfermeiro
Authors: Batista de Alencar Alexsandro , De Lima Carvalho Carolina Maria , Marques Araújo Michell Ângelo , Ximenes Guimarães José Maria , Alves e Souza Ângela Maria , Chaves Costa Edmara
Published: October 2022

Objetivo: analisar, por meio das narrativas de enfermeiros, as concepções e práticas sobre sua atuação produzidas no percurso da formação em saúde mental. Método: estudo qualitativo baseado na Teoria Fundamentada nos Dados realizado por meio de entrevistas semiestruturadas com enfermeiros dos Centros de Atenção Psicossocial de uma capital do Nordeste brasileiro, de agosto a dezembro de 2017. Os dados foram analisados e validados segundo os pressupostos do arcabouço teórico utilizado. Resultados: participaram oito enfermeiros que apontaram a formação universitária como o primeiro ponto de preparação para atuação em saúde mental, concebida como experiência “traumática” e geradora de grande ansiedade, interferindo na percepção, identificação e inserção na área. Conclusões: é necessário refletir criticamente sobre a formação do enfermeiro em saúde mental, por persistir conteúdos teóricos e experiências práticas discordantes com o paradigma psicossocial da Reforma Psiquiátrica brasileira. Tal reflexão é imprescindível para novos modos de formar para o cuidado.
Teorias norteadoras de Enfermagem com foco nos cuidados paliativos
Authors: Dos Santos Santiago Ribeiro Beatriz Maria , de Marchi Barcelos Dalri Rita de Cassia
Published: October 2022

.
Envolvimento do enfermeiro na tomada de decisão no ambiente hospitalar: revisão integrativa da literatura
Authors: Antunes Menegon Fernando Henrique , Guedes dos Santos José Luís , Gonçalves Natália , De Oliveira Vargas Mara Ambrosina , Klock Patricia , Coelho Amestoy Simone
Published: October 2022

Objetivo: evidenciar o conhecimento desenvolvido sobre o envolvimento do enfermeiro na tomada de decisão no ambiente hospitalar. Método: revisão integrativa da literatura, nas bases de dados Publisher Medline, Cumulative Index to Nursing and Allied Health Literature, Scientific Electronic Library Online, Literatura Latino-Americano e do Caribe em Ciências da Saúde e a Base de dados de Enfermagem, de 2009 a 2021. Resultados: a amostra foi composta por 13 artigos selecionados. A discussão do envolvimento do enfermeiro no ambiente hospitalar está em ascensão. Os estudos indicam que os enfermeiros têm expectativa de envolver-se na decisão. O engajamento na tomada de decisão contribui para qualificação do cuidado aos pacientes e aumentar autonomia e reconhecimento profissional. Conclusão: o envolvimento dos enfermeiros na tomada de decisão contribui para mudanças organizacionais e qualificação da assistência e segurança do paciente.
Desgastes físicos e emocionais do enfermeiro decorrentes do atendimento pré-hospitalar móvel
Authors: Hyppolito Barbosa Karoline , Dos Santos Santiago Ribeiro Beatriz Maria , Giorio Maria Clara , Nishikawa Yagi Mara Cristina , Coutinho de Oliveira Leticia , Eiko Karino Marcia
Published: October 2022

Objetivo: descrever as principais queixas causadas pelas cargas psíquicas no processo de trabalho dos enfermeiros no atendimento móvel pré-hospitalar. Método: pesquisa qualitativa realizada com 15 enfermeiros do Serviço de Atendimento Móvel de Urgência de uma cidade do norte do Paraná. O instrumento de coleta tinha informações de caracterização sociodemográfica e do trabalho. Os dados foram submetidos à análise de conteúdo. Resultados: evidenciaram-se desgastes emocionais e físicos causados pelas cargas psíquicas associadas ao estresse no trabalho: apreensão, ansiedade, irritação, nervosismo, insônia, falta de paciência, imediatismo das coisas, medo do desconhecido, alteração dos sinais vitais, frustração, desânimo, tristeza, desmotivação, ausência de reconhecimento profissional, força física, entre outros. Conclusões: recomenda-se que a instituição disponibilize suporte psicológico, momentos de confraternização/lazer, vigilância em Saúde do Trabalhador, entre outras atividades que podem proporcionar qualidade de vida no trabalho do enfermeiro, reduzindo desgastes físicos e emocionais ocasionados pelo desempenho da sua função no Serviço Móvel de Urgência.
Epidemiologia do câncer cervical no Brasil: uma revisão integrativa
Authors: Corina Gomes Lorrana , Conceição Pinto Mônica , De Jesus Reis Bruna , Santos Silva Dândara
Published: October 2022

Objetivo: avaliar as publicações científicas que apresentam informações sobre a tendência da incidência e da mortalidade por câncer de colo de útero no Brasil. Método: revisão integrativa de artigos publicados entre os anos de 2011 e 2020, a partir de busca na Biblioteca Virtual em Saúde, utilizando os descritores “incidência”, “câncer do colo do útero” e “mortalidade”. Resultados: foram selecionados 37 artigos. Esta revisão tornou evidente que a maioria dos estudos demonstrou uma tendência decrescente da incidência e mortalidade por câncer do colo do útero no Brasil. Entretanto, esses indicadores ainda são considerados elevados, sobretudo nas regiões Norte e Nordeste do país. Conclusão: apesar da tendência da redução da incidência e mortalidade, o câncer cervical continua sendo um problema de saúde pública no Brasil.
Brain-Derived Neurotrophic Factor And Coronary Artery Disease
Authors: Kytikova Oksana Yu. , Novgorodtseva Tatyana P. , Denisenko Yulia K. , Antonyuk Marina V. , Gvozdenko Tatyana A. , Atamas Olga V.
Published: October 2022

Coronary artery disease (CAD) is defined as myocardial damage developing as a result of its organic and functional changes, and leading to impaired blood flow through the coronary arteries. An important pathogenetic component of CAD is atherosclerosis. Currently, key aspects of the molecular relationship between inflammation and atherosclerosis are being actively studied, the immunometabolic theory of atherosclerosis is being discussed, along with an involvement of perivascular adipose tissue in the pathogenesis of this pathology, due to its ability to respond to atherogenic stimuli via developing inflammatory reactions. Evidence has been accumulated that in patients with CAD, both in their blood and perivascular adipose tissue, the level of neurotrophic factors (in particular, brain-derived neurotrophic factor, BDNF) changes, which may be a promising area of research from the standpoint of studying this factor as a therapeutic target for atherosclerosis in CAD. Neurotrophic growth factors control the functioning of both immune and nervous systems, and the balance of energy metabolism and innervation of adipose tissue. They affect vascular homeostasis, and are also involved in causing and stopping inflammation. Currently, there are data on the role of BDNF in the pathogenesis of cardiovascular, neurodegenerative and metabolic diseases, and on the effect of polyunsaturated fatty acids and eicosanoids on the level of BDNF and, accordingly, the development and progression of coronary artery atherosclerosis. Our review summarizes published data (2019-2021) on the pathophysiological and pathogenetic mechanisms of the relationship between BDNF and CAD (atherosclerosis).
Preliminary Analysis Of Early And Late Radiation Responses In 3D Image-Guided Brachytherapy For Cervical Cancer
Authors: Andreyeva Olga B. , Adylkhanov Tasbolat A. , Kaidarova Dilyara R. , Isayev Isa G. , Kurmangaliyev Tolegen S. , Khismetova Zaituna A. , Glushkova Natalya E.
Published: October 2022

Rationale – The use of 3D image-guided brachytherapy (3D-IGBT) allows adequately optimizing the dose distribution to bring a target therapeutic dose to clinical target volume (CTV), thereby minimizing an impact on critical organs, while ensuring a decrease in the incidence and severity of radiation-caused complications. Use of 3D-IGBT also allows improving the quality of life in patients with cervical cancer. Objective – To conduct a preliminary analysis of the incidence of early and late radiation responses in 3D-IGBT of locally advanced cervical cancer (LACC). Materials and Methods – The objects of our study were female patients with stages IIB and IIIB of cervical squamous cell carcinoma, without confirmed metastases, preceding chemotherapy (CHT) and/or radiation therapy (RT), and surgical interventions in this localization, who underwent combined chemoradiotherapy during the study. Results – Statistically significant results were obtained when analyzing the incidence of late radiation responses. It is important to point out that when assessing early toxicity in the main group with 3D-IGBT, grade 3 responses were not diagnosed, while in the control group, they were observed in 4 (9.1%) women. For instance, the manifestation of grade 3 delayed radiation injuries in the rectum was diagnosed in 3 (6.8%) women in the control group, while in the main group, they were not detected. Grade 2 cystitis was observed in a smaller number of women in the group with 3D-IGBT, compared with the control group (9.1% vs. 13.6%, p<0.05). Grade 3 delayed radiation responses in the bladder were diagnosed in 4 (9.1%) women in the control group, whereas among the patients of the main group with 3D-IGBT, they were not recorded at all (p <0.05). Grade II reactions in the vaginal mucosa and cervix were diagnosed more often in the control group (16.7% vs. 13.6%, p<0.05). Conclusion – Hence, the method we have used to optimize the treatment of LACC by means of 3D planning in accordance with toxicity criteria exhibited a definite advantage, compared with RT with 2D planning. Based on the results of our research, we concluded that optimization of RT for LACC using 3D-IGBT created clinically favorable conditions for effective therapy: it reduced the risk of displacement of the applicators and decreased an impact on the patient via reducing the total radiation doses and incidence of severe early and late toxic effects, providing good outcomes of local control regardless of tumor size and clinical stage.
Effect Of Low-Level Laser Therapy On Inflammatory Sequеlae Of Impacted Mandibular Third Molar Surgery: A Single-Blind, Placebo-Controlled, Randomized Clinical Trial
Authors: Hamad Shehab Ahmed
Published: October 2022

Objective — Postoperative pain, facial swelling, and limitation of mouth opening are common sequеlae of lower third molar surgery. The objective of the study was to evaluate the effect of Low- level laser irradiation in controlling these sequеlae. Material and Methods — This randomized, single-blinded, split-mouth pilot study was carried out at the department of oral and maxillofacial surgery, university affiliated hospital, Erbil, Iraq. The study was conducted on 20 patients (13 males and 7 females), with a mean age of 26.3±7.4 years, who needed surgical removal of symmetrical bilateral impacted lower third molars. In each patient, one side was treated by low level laser and the other side was control. Laser irradiation was performed by postoperative single intraoral application of 940 nm laser beam at four points. Pain, trismus, and facial swelling were evaluated at the first, third, and seventh postoperative days. The data were analyzed using Mann–Whitney U test and unpaired t -test. Results — As compared to the control sides, low- level laser irradiated sides showed a significant reduction in visual analogue pain scales (VAS) during the first three postoperative days (P<0.05). The VAS scores of the laser treated sides were 4.46, 4.00, and 3.35 as compared to 6.58, 5.82, and 5.17 for the control sides. The swelling, and trismus were significantly reduced on the first and third postoperative days in the laser treated sides, as compared to the control sides (P<0.05). The facial measurements during the first and third postoperative days were 108.72 mm and 114.77 mm in the laser sides and 113.57 mm and 118.43 mm in the control sides. The degree of mouth opening during the first and third postoperative days were 33.48 mm and 30.37 mm in the laser sides and 27.93 mm and 25.58 mm in the control sides Conclusions — Single intraoral application of low- level laser is effective in reducing pain, swelling and trismus after mandibular third molar surgery. Therefore, it can be used as an adjuvant in controlling postoperative complications after lower third molar surgery.
Prevalence Of Sleep Disorders Among Physicians And Nurses During COVID-19 Pandemic
Authors: Karnaukhov Vladislav E. , Narodova Ekaterina A. , Demko Irina V. , Shnayder Natalia A. , Narodova Valeriya V. , Dmitrenko Diana V. , Nasyrova Regina F.
Published: October 2022

The objective of our review was to analyze studies of prevalence sleep disorders among medical workers during COVID-19 pandemic. Material and Methods — Overall, during the analyzed period, studying domestic and foreign databases, we identified 94 publications on the development of sleep disorders among medical personnel working during COVID–19 pandemic in 2000-2021. However, only 88 of these publications complied with the objective of the review. We included 75 full-text publications in this review. Results — Physicians and nurses during COVID-19 pandemic do not have the opportunity to take therapy aimed at combating the symptoms of sleep disorders, due to the need to maintain sufficient attention and the risk of developing excessive drowsiness while on duty in a COVID -19 hospital. The latter can have a negative impact on their professional activities. Thus, this problem certainly requires professional psychotherapeutic correction. Unfortunately, not all medical institutions have such specialists. Conclusion — Based on the literature review, we found out that health care workers have a high risk of developing sleep disorders. This can include violations of the circadian rhythm, a decrease in the quality and duration of night sleep, daytime hypersomnia caused by shift work in a hospital. An additional factor affecting the frequency and severity of sleep disorders in healthcare workers (physicians and nurses) is chronic stress, the importance of which has increased during the COVID-19 pandemic. Currently, the above problem has not been completely solved and requires research in this area and the development of new programs to help medical personnel.
Interaction Of Immune Response Mediator Genes In A Predisposition To Juvenile Idiopathic Arthritis
Authors: Nazarova Liliia Sh. , Danilko Ksenia V. , Malievsky Viktor A. , Karimov Denis O. , Bakirov Akhat B. , Viktorova Tatyana V.
Published: October 2022

Background/objective — The goal of our study was to investigate the role of interaction between the polymorphic loci of immune response mediator genes (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, and PADI4 rs2240336) in the formation of a genetic predisposition to juvenile idiopathic arthritis (JIA). Material and Methods — The study involved 330 JIA patients and 342 volunteers from the Republic of Bashkortostan. Genotyping was conducted via the real-time polymerase chain reaction. The gene-gene interactions were studied using the multifactor dimensionality reduction algorithm. Results — In general analysis, the best model of gene-gene interaction in JIA was a combination of IL1B rs16944 – IL10 rs1800872 – NFKB1 rs28362491 – PADI4 rs2240336 polymorphic loci. However, after gender-based stratification the best results were obtained when examining the combinations of IL6 rs1800795 – PADI4 rs2240336 loci in girls and of IL10 rs1800872 – IL6 rs1800795 – IL2RA rs2104286 loci in boys. Within all of these models, the genotype combinations associated with both augmented and reduced JIA risks were identified (taking into account gender-specific differences). Conclusion — The results of our study implied that an important role in the formation of a predisposition to JIA is played by gene-gene interactions of IL1B rs16944, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, NFKB1 rs28362491, and PADI4 rs2240336 polymorphic loci (taking into account gender-specific differences).
Assessment of prognostic factors in pediatric adrenocortical tumors: a systematic review and evaluation of a modified S-GRAS score
Authors: Riedmeier Maria , Decarolis Boris , Haubitz Imme , Reibetanz Joachim , Wiegering Armin , Härtel Christoph , Schlegel Paul-Gerhardt , Fassnacht Martin , Wiegering Verena
Published: October 2022

Objective

Pediatric adrenocortical carcinoma (pACC) is rare and prognostic stratification remains challenging. We summarized the clinical prognostic factors of pACC and determined the prognostic value of the pediatric scoring system (pS-GRAS) in adaption to the recommendation (S-GRAS) of the European Network for the Study of Adrenal Tumors for the classification of adult ACC.

Design

Analysis of pACC patients of 33 available retrospective studies in the literature.

Methods

We searched the PubMed and Embase databases for manuscripts regarding pACC. The pS-GRAS score was calculated as a sum of tumor stage (1 = 0; 2–3 = 1; 4 = 2 points), grade (Ki67 index/rate of mitosis 0–9%/low = 0; 10–19%/intermediate = 1; ≥20%/high = 2 points), resection status (R0 = 0; RX = 1; R1 = 2; R2 = 3 points), age (<4 years = 0; ≥4 years = 1 point), hormone-related symptoms (androgen production = 0; glucocorticoid/mixed/no hormone production = 1 point) generating 10 scores and 4 groups (1: 0–2, 2: 3–4, 3: 5, 4: 6–9). The primary endpoint was overall survival (OS).

Results

We included 733 patients. The median age was 2.5 years and >85% of pACC showed hormone activity (mixed 50%, androgen 29%, glucocorticoid 21%). Androgen production was associated with a superior OS. Increasing age correlated with higher rates of inactive or only glucocorticoid-producing tumors, advanced tumor stage, and case fatality. Especially infants < 4 years showed more often low-risk constellations with an increased OS for all tumor stages. The pS-GRAS score correlated with clinical outcome; median OS was 133 months (95% CI: 36–283) in group 1 (n = 49), 110 months (95% CI: 2.9–314) in group 2 (n = 57), 49 months (95% CI: 5.8–278) in group 3 (n = 18), and 16 months (95% CI: 2.4–267) in group 4; (n = 11) P < 0.05).

Conclusion

The pS-GRAS score seems to have a high predictive value in the pACC patients, may serve as a helpful tool for risk stratification in future studies, and should be evaluated prospectively in an international context.
Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis
Authors: Prakash Yadav Ram , Leskinen Sini , Ma Lin , Mäkelä Juho-Antti , Kotaja Noora
Published: October 2022

In brief

Proper regulation of heterochromatin is critical for spermatogenesis. This study reveals the dynamic localization patterns of distinct chromatin regulators during spermatogenesis and disrupted sex chromatin status in spermatocytes in the absence of DICER.

Heterochromatin is dynamically formed and organized in differentiating male germ cells, and its proper regulation is a prerequisite for normal spermatogenesis. While heterochromatin is generally transcriptionally silent, we have previously shown that major satellite repeat (MSR) DNA in the pericentric heterochromatin (PCH) is transcribed during spermatogenesis. We have also shown that DICER associates with PCH and is involved in the regulation of MSR-derived transcripts. To shed light on the heterochromatin regulation in the male germline, we studied the expression, localization and heterochromatin association of selected testis-enriched chromatin regulators in the mouse testis. Our results show that HELLS, WDHD1 and BAZ1A are dynamically expressed during spermatogenesis. They display limited overlap in expression, suggesting involvement in distinct heterochromatin-associated processes at different steps of differentiation. We also show that HELLS and BAZ1A interact with DICER and MSR chromatin. Interestingly, deletion of Dicer1 affects the sex chromosome heterochromatin status in late pachytene spermatocytes, as demonstrated by mislocalization of Polycomb protein family member SCML1 to the sex body. These data substantiate the importance of dynamic heterochromatin regulation during spermatogenesis and emphasize the key role of DICER in the maintenance of chromatin status in meiotic male germ cells.
La Construcción del Perfil Presidencial en la Francia de la V República. 1965-2017
Authors: Casal Daniel
Published: October 2022

El paper analiza el sistema de reclutamiento de las élites políticas de la V República Francesa a partir del análisis de la Presidencia, como institución central de la misma, constatando la alta cualificación técnica y profesional que define la trayectoria de todos los jefes del estado que ha tenido Francia entre 1965 y 2017. La investigación parte de la delimitación conceptual del modelo semipresidencial y de los aspectos específicos que definen el sistema político francés así como el procedimiento de elección presidencial. Una vez estudiadas las principales dimensiones de la arquitectura institucional de la Presidencia de la República, la investigación analiza las variables personales, educativas, profesionales y políticas que definen el perfil de los ocho Presidentes de la V República desde que en 1965 se implementase el modelo de elección directa de la jefatura del estado.
Procesos de digitalización, seguimiento de la información política y cambios en la cultura política de América Latina
Authors: Cazorla Martín Ángel , Rebollo Merino Marina , Jarque Gibert Marc
Published: October 2022

El presente trabajo analiza los procesos de digitalización en América Latina a lo largo de los últimos años, al mismo tiempo que su relación con los cambios en las dinámicas de seguimiento de la información y participación política. En primer lugar, se realiza una caracterización de los cambios en la cultura política de la región, teniendo en cuenta tanto sus factores estructurales como condicionantes subjetivos y cognitivos, prestando especial atención a la confianza y satisfacción política e institucional. En segundo lugar, se presenta el estado de la cuestión sobre los medios de comunicación en la región y su relación con la cultura política para así profundizar en algunas de las dinámicas de participación política ciudadana y sus cambios a partir de los nuevos medios digitales. Posteriormente se analizan los resultados del trabajo de campo, obtenidos a partir de la recopilación de datos de sucesivas oleadas del Latinobarómetro1.
En relación con los procesos de digitalización y al uso de medios digitales para la información política, los resultados muestran el gran avance que ha tenido la región, al mismo tiempo que pone de manifiesto las grandes diferencias entre países, encontrando como principal variable explicativa el desarrollo económico. En cuanto a la relación entre los componentes de cultura política tenidos en cuenta y el uso de medios digitales para la información política, los resultados muestran el papel que tanto la confianza institucional como la satisfacción democrática juegan en el uso político de medios digitales.
Chemically Plasticized Chitosan Films by Grafting Succinic Acid: Surface Roughness and Mechanical Properties
Authors: Hadi S. Al-Lami
Published: October 2022

A useful alternative to conventional plastic packaging manufactured from fossil fuels is packaging constructed of a biodegradable polymer. The final qualities of the chitosan cast films heavily depend on the type of plasticizer used and how it is incorporated into the chitosan-based material. This work investigates the synthesis of chitosan chemically grafted with succinic acid to improve the physical and mechanical properties of the film. The cortex of local shrimp was used to make a chitosan extract with a molecular weight of 2.702x105 g/mole and a deacetylation level of 80%. The chemically plasticized chitosan film was characterized by FTIR. It was found that chitosan and grafted chitosan film spectra were different from each other, implying the true grafting of succinic acid had occurred and the main backbone of the chitosan structure was unaffected. An examination of the mechanical properties of the films revealed that the results of the tensile strength measurement showed an improvement in the strength and %elongation at break for the chitosan grafted with succinic acid cast film for packaging, which is one of the potential applications for biodegradable chitosan.
Las desigualdades educativas en Argentina
Authors: Piovani Juan Ignacio
Published: October 2022

En este artículo se presenta un análisis sincrónico de la situación escolar y las trayectorias educativas de cuatro cohortes de niños y adolescentes, cuyas edades corresponden a fases iniciales y avanzadas de los estudios primarios y secundarios, de acuerdo con las trayectorias teóricas que define el sistema educativo argentino. Se reportan las disparidades intra cohorte y entre cohortes en relación con: la cobertura del sistema escolar, la sobreedad, el abandono y la terminalidad; la adquisición de competencias informáticas y en lenguas extranjeras; y el desempeño académico. El artículo se basa en el análisis secundario de los datos de la encuesta Enes-Pisac y de las pruebas estandarizadas Aprender del Ministerio de Educación de la Nación. Los resultados ponen en evidencias fuertes desigualdades educativas, a pesar del alto nivel de cobertura del sistema escolar, asociadas principalmente con factores socioeconómicos, el tipo de gestión escolar y la región de residencia.
Knowledge, Attitudes, and Experiences of a Group of Turkish Dentists regarding Child Abuse
Authors: Ceyhan Derya
Published: October 2022

Child abuse is a universal problem with critical lifelong effects. This study aimed to evaluate knowledge, attitudes, experiences of dentists regarding child abuse and to increase relevant awareness of them. A self-administered questionnaire with 48 questions about dentists’ personal and educational information and their level of knowledge, attitudes, experiences on child abuse was implemented. Out of targeted 305 participants, 183 (60.0%) returned completely filled out questionnaires. Majority of participants knew signs and symptoms of child abuse. Of the participants, more than half were well-informed on what to do, however, one quarter had no knowledge about where to report in case of child abuse. In identifying child abuse, 39.3% of the participants found themselves inadequate. The most commonly stated reason for low rate of reporting was hesitancy to identify the case as abuse, and all participants needed more training. Only 12 (6.6%) participants suspected a case of child abuse. Dentists who had children and were long-time experienced and generalist did not have sufficient knowledge about legal obligations, signs and symptoms of child abuse (p<0.05). Arrangements and training programs to increase knowledge, awareness, and responsibility levels of dentists about child abuse appear to be a critically important topic.
Species-specific features of Aonchoteca bursata and Baruscapillaria obsignata (Nematoda, Capillariidae), infecting domestic chickens (Gallus gallus dom.)
Authors: Yevstafieva V. , Melnychuk V. , Bakhur T. , Nagorna L. , Nikiforova O. , Yatsenko I. , Reshetylo O.
Published: October 2022

Capillariids are a family of parasitic nematodes characterised by significant fluctuations of the taxonomic value of morphological features at the genus and species levels. Here, we present the results of a study identifying features of Baruscapillaria obsignata and Aonchoteca bursata, obtained from domestic chickens. Aside from the morphological differences in the studied capillariid species, significant differences in 14 metrical parameters of males and in 8 in females were found out. The comparative metrical analysis of eggs revealed significant differences in 4 parameters between B. obsignata and A. bursata. According to the conducted analysis, metrical comparative indices may enhance and increase the effectiveness of species identification based on the species-specific features of males and females.
The Contribution of Ernő Tárkány Szücs to Hungarian Ethnography
Authors: Paládi-Kovács Attila
Published: October 2022

Ernő Tárkány Szücs was a prominent figure in Hungarian social ethnography between 1944 and 1984. His involvement in the movement for collecting legal folk customs began as a university student in 1941. Among his professors and mentors, he was particularly influenced by György Bónis, Károly Viski, and József Venczel. His first large-scale study, published in 1944, was a presentation of legal folklore from the village of Mártély. At the same time, he investigated the folk laws related to sheep farming and the legal customs with respect to inheritance in the Hungarian villages in Transylvania. He published two substantial volumes containing the wills of peasant citizens of Hódmezővásárhely written between 1730 and 1796, and later the testaments of serf farmers from the town of Makó. He published a data collection containing around 10,000 ownership certificates and an analytical study in German on the branding of horses and cattle, accompanied by illustrations. He carried out research on the legal customs associated with Hungarian mining in the 17th to 19th centuries and elaborated Hungary's draft mining law. His principal work — on Hungarian Legal Folk Customs — is a substantial, comprehensive, and incomparably rich corpus of legal ethnography and the history of law. His work also gained recognition abroad: he spoke at many international conferences and was elected as a member of several international organizations.
Validation of the Ten-Item Internet Gaming Disorder Test (IGDT-10) based on the clinical diagnosis of IGD in Japan
Authors: Mihara Satoko , Osaki Yoneatsu , Kinjo Aya , Matsuzaki Takanobu , Nakayama Hideki , Kitayuguchi Takashi , Harada Takayuki , Higuchi Susumu
Published: October 2022

Background and aims

Although the Ten-Item Internet Gaming Disorder Test (IGDT-10) has been translated into Japanese and widely used, the Japanese version has not previously been validated. We used the clinical diagnosis of IGD as a gold standard for validating the test.

Methods

The Japanese version was validated using 244 gamers drawn from the general young population in Japan. Expert interviews using the Japanese version of the Structured Clinical Interview for Internet Gaming Disorder evaluated diagnoses of Internet gaming disorder (IGD). This resulted in a diagnosis of IGD for eight individuals, categorized as the gold standard group. The screening performance of the two Japanese versions with different scoring conditions was examined: the scoring method proposed by the original study (original version) and a less stringent scoring method where responses of either “often” or “sometimes” were regarded as affirmative (modified version).

Results

The results of the sensitivity and specificity analyses, the Cronbach's alpha and the receiver operating characteristics analysis revealed a higher screening performance for the modified versus the original version. The optimum cutoff for the modified version was 5 or more – the sensitivity, specificity, and Youden's index were 87.5, 85.2, and 72.7%, respectively. The rate of probable IGD using the original and modified versions were 1.8% and 11.3%, respectively.

Discussion and conclusion

A less stringent scoring method for the Japanese version of IGDT-10 showed a higher screening performance than the original scoring method. Future studies comprising different ethnic groups and gaming cultures should further examine the suggested scoring method.
FUNGSI PENGHULU MENURUT PERMENPAN NOMOR 62 TAHUN 2005 SEBAGAI PUNGSI MEDIATOR DI TINGKAT KECAMATAN DALAM KASUS PERCERAIAN (STUDI PADA KUA KECAMATAN KARANGTENGAH KABUPATEN CIANJUR)
Authors: Hafifi Ikmal , Saepullah Usep
Published: October 2022

Abstrak: Salah satu upaya mewujudkan rumah tangga yang sakinah mawaddah warahmah dan untuk menekan angka perceraian yang terjadi di wilayah Kecamatan tidak serta merta memberikan surat pengantar pengajuan cerai talak atau cerai gugat kepada pasangan suami istri yang akan mengajukan gugatan ke Pengadilan Agama (PA) sebelum pasangan suami isteri tersebut mendapatkan mediasi Kantor Urusan Agama Kecamatan. Terkait dengan hal tersebut, maka  fokus masalah dalam penelitian ini adalah Peran Penghulu Menurut Permenpan No 62 Tahun 2005 sebagai Fungsi Mediator di Tingkat Kecamatan Dalam Kasus Perceraian (Studi pada KUA Kecamatan Karangtengah Kabupaten Cianjur).Peran penghulu selain menikahkan juga tempat masyarakat konsultasi dan mediasi dalam menyelesaikan hukum keluarga dalam perkawinan. Tugas dan fungsi (Tusi) ini tidak terlepas dari tugas dan fungsi KUA sebagaimana termuat dalam Permenpan No. 62 tahun 2005 Pasal 6d “Pelayanan dan konsultasi nikah/rujuk meliputi Penasihatan dan konsultasi nikah/rujuk”.Tujuan penelitian ini adalah untuk megetahui peran penghulu sebagai mediator perselisiahan perkawinan, walaupun regulasi belum mengatur hal demikian secara jelas. Metode penelitian ini deskriptif analitis yaitu menganalisa peklaksanaan konsultasi dan mediasi masalah sengketa perkawinan/keluarga dimasyarakat Kecamatan Karangtengah terhadap penghulu.Hasil dari penelitian ini bahwa pelaksanaan mediasi dalam perkara perceraian di Kantor Urusan Agama Kec. Karangtengah dilakukan secara bertahap, tahap awal mengumpulkan atau mengidentifikasi keluhan pemohon yang mau bercerai, selanjutnya mediator melaksanakan mediasi dengan memberi nasehat untuk mencari solusi damai dengan memberikan pemahaman kepada  suami istri tentang hak dan kewajiban masing-masing. Analisi penulis, bahwa prosedur mediasi di KUA Kec. Karangtengah tidak terlepas dari alur mediasi yang terdapat dalam PERMA No. 1 tahun 2016 tentang Alur Mediasi di Pengadilan.Rekomendas dari penelitian ini diharapkan dapat menjadi naskah akademik untuk dijadikan pertimbangan pada kepastian hokum mengenai penghulu sebagai mediator.   Kata Kunci: Penghulu, Perceraian , Mediasi, Perkawinan
Dinamika Politik dalam Penyusunan Undang-Undang Nomor 1 Tahun 1974 Tentang Perkawinan
Authors: Kamila Maulida Zahra
Published: October 2022

Abstract: Marriage is an inseparable bond and creates many legal implications for married couples, for that we need clear legal rules regarding marriage law. The formulation of a law has its own process and dynamics, many factors influence the birth of the law, as well as the birth of Law Number 1 of 1974 concerning Marriage, there are political dynamics in it. The methodology used in this paper is content analysis with a normative approach, the data obtained from the literature study and the data analysis using a qualitative approach. The focus of this paper is to mengeta h ui political dynamics that occur in the process of formulating the Marriage Act. At first there was no official regulation from the government regarding marriage law, therefore there were multiple interpretations regarding this marriage rule considering the plural and diverse Indonesian society, so the presence of this Marriage Law brought fresh air to marriage law in Indonesia.Keywords: Politic, Marriage LawAbstrak: Perkawinan adalah ikatan yang tidak terpisahkan dan menimbulkan banyak implikasi hukum terhadap pasangan suami istri, untuk itu diperlukan aturan hukum yang jelas mengenai hukum perkawinan. Perumusan suatu Undang-Undang memiliki proses dan dinamikanya sendiri, banyak faktor yang mempengaruhi lahirnya Undang-Undang, begitupun lahirnya Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan terdapat dinamika politik di dalamnya. Metodologi yang digunakan dalam tulisan ini adalah analisis konten dengan pendekatan normatif yang datanya diperoleh dari studi literatur dan data analisanya menggunakan pendekatan kualitatif. Fokus dari tulisan ini adalah untuk mengetahui dinamika politik yang terjadi dalam proses perumusan Undang-Undang Perkawinan. Pada mulanya belum ada aturan resmi dari pemerintah mengenai hukum perkawinan, oleh karenanya terdapat multitafsir mengenai aturan perkawinan ini mengingat masyarakat Indonesia yang majemuk dan beraneka ragam, maka hadirnya Undang-Undang Perkawinan ini membawa angin segar bagi hukum perkawinan di Indonesia.Kata Kunci: Politik, Undang-Undang Perkawinan
ANALISIS DAMPAK PMA NO.12 TAHUN 2016 TENTANG BIAYA NIKAH GRATIS (RP.0) DI KUA KECAMATAN BUNUT MENURUT HUKUM KELUARGA ISLAM
Authors: SHADIQOH MILLAH
Published: October 2022

This research is motivated by the increasing number of free wedding events (Rp.0) at KUA Bunut District, which is carried out by brides with low education and economic categories. This thesis is the result of field research at KUA Bunut District, Pelalawan Regency. The study was conducted to analyze the implementation and impact of the Minister of Religion Regulation (PMA) No. 12 of 2016 concerning free marriage fees, at the KUA of Bunut District and the views of Islamic family law on these rules in the Maqashid sharia frame.This research data was collected from the Regulation of the Minister of Religion Number 12 of 2016 as primary data, as well as interviews with the parties implementing this regulation, namely 5 KUA officers in Bunut sub-district, and 10 brides who registered their marriage at KUA Bunut sub-district for free.The results of this study indicate First, in the implementation of PMA Number 12 of 2016 cannot be realized, due to the ignorance of the KUA and the bride regarding this rule, in addition to the previous rules, namely PP number 48 of 2014 and also PP number 19 of 2015, have similarities, in in terms of content so that the KUA still uses these rules, and many brides prefer to carry out marriages for free during the KUA Operational hours and its implementation in the KUA Office, Second, the impact of the Minister of Religion Regulation No. 12 of 2016 concerning Free Marriage Fees outside the KUA in the KUA Bunut District, divided into 2 parts, namely positive and negative impacts for both the bride and the KUA in Bunut sub-district. Third, while in the view of Islamic family law in the Maqashid Sharia concept, this rule is considered to be able to bring harm compared to Mashlahat, this is not in accordance with the goal of Maqashid Sharia, namely maintaining offspring. (hifzdu Nasab).That way, this rule cannot be implemented properly and it is feared that it will cause problems in the future for the bridal couple in fostering the Sakinah mawaddah warrahmah family, which is the dream of the bride and groomKeywords : Marriage, Religion, Minister, Goal