bluuebunny/crossref_metadata_2025 huggingface dataset:
Biocatalytic Hydroxylation of Progesterone by Penicillium aculeatum
Authors: Nickavar Bahman , Mehmannavaz Maryam
Published: September 2024

Background:

Biotransformation is a powerful process for producing steroid compounds,
and fungi are commonly regarded as effective biological agents for this purpose. They facilitate
reactions that are difficult to perform via conventional chemical methods.

Objective:

In the current study, the ability of Penicillium aculeatum to biotransform progesterone
was studied.

Methods:

Forty-eight hours after the incubation of active P. aculeatum with substrate (progesterone),
the reaction medium was extracted and chromatography methods isolated metabolites. The
chemical structures of the products were characterized by various spectroscopic techniques.

Results:

Two main hydroxylated products, 14α-hydroxyprogesterone, and 7α,14α-dihydroxyprogesterone,
were finally identified.

Conclusion:

P. aculeatum may be considered a functional biocatalyst for some biotransformation
processes.
Antioxidant-Oxidative Stress Balance in Chemoprevention of Cancer
Authors: Sidhic Jameema , Prasad Aparna , Narayanankutty Arunaksharan , George Satheesh , George Blassan
Published: September 2024

Every year, millions of individuals are diagnosed with cancer, making it one
of the primary causes of mortality worldwide. It is estimated that around 10 million
cancer-related deaths will occur, emphasizing the enormity of the impact of this disease
on individuals and society as a whole. There are a multitude of side effects associated
with anticancer drugs, and each drug, regardless of its class, has its unique set of
adverse reactions. The overproduction of reactive oxygen species (ROS) and
consequent accumulation of oxidative stress are significant contributors to adverse
reactions, particularly for medications directed towards DNA. This issue has prompted
the exploration of various dietary supplements to mitigate these unwanted side effects.
Among these supplements, antioxidants have become increasingly prevalent as a
chemotherapy adjuvant. Nevertheless, many cancer specialists discourage the
consumption of antioxidant-rich supplements, as they have the potential to interfere
with cancer-killing modalities that generate free radicals. There is ongoing debate
regarding whether the use of antioxidant supplements impacts the effectiveness of
cancer chemotherapy. Specific antioxidant supplements may lessen toxicities and bad
effects, according to limited evidence that is both high quality and sample size. In this
chapter, details of the role of antioxidants in cancer therapy and chemoprevention are
discussed.
Potensi Bakteri Pelarut Fosfat pada Lahan Tegakan Hutan dan Perkebunan Singkong di Kawasan Kampus IPB Dramaga Bogor
Authors: Firlandiana Maulidi , Khairiyah Yaumil , Perala Iwan , Mustikaningrum Dhina , Kristiawan Kristiawan , Maimunah Maimunah , Suprayitno Suprayitno , Prasetya Herry , Dewi Setyana Abdi , Subiyanto Subiyanto
Published: September 2024

Tanaman memerlukan nutrisi yang cukup untuk pertumbuhan dan perkembangan, salah satunya yaitu fosfor (P). Namun tanaman hanya dapat menyerap P dari tanah dalam bentuk ion fosfat (H2PO4- dan HPO42-). Tantangan besar yang dilakukan untuk menyediakan P terlarut atau tersedia, terjawab oleh penemuan Bakteri Pelarut Fosfat (BPF). Mikrob ini menghasilkan asam-asam organik yang dapat melarutkan senyawa fosfat kompleks dan atau mengikat kation dari ion (PO43-) untuk melepaskan P tersedia dalam tanah. Areal rhizosfer tanah memiliki potensi keragaman mikrob yang tinggi karena menyediakan sumber makanan (eksudat) yang dikeluarkan dari akar tanaman. Penelitian ini bertujuan menentukan kualitas isolat BPF dari ekosistem perkebunan singkong dan hutan Kampus IPB Dramaga dengan Indeks Pelarut Fosfat (IPF) tertinggi pada berbagai sumber P dan variasi pH serta menentukan isolat BPF yang bersifat non-patogenik terhadap manusia, hewan, dan tanaman. Penelitian ini diawali dengan mengisolasi BPF dari areal rhizosfer, menumbuhkannya pada media selektif Pikovskaya, identifikasi morfologi koloni secara makroskopis, seleksi koloni BPF yang menghasilkan halozone (zona bening), mengukur IPF, dan mengujinya pada media Pikovskaya dengan berbagai sumber P dan tingkatan pH. Hasil isolasi menunjukkan adanya 9 isolat 2 diantaranya dari tegakan hutan dan 7 dari perkebunan singkong yang menghasilkan halozone. Isolat 6P dan 7P dari tegakan hutan memiliki IPF tertinggi berturut-turut sebesar 3,10 dan 3,33. Adapun isolat BPF hanya dapat mengasilkan halozone pada media sumber P dari kompleks Ca-P dengan kondisi pH basa dan pH tanah. Dari 9 isolat terpilih, 6 diantaranya yaitu isolat 1P, 3P, 4P, 6P, 7P, dan 9P teruji bersifat non-patogen terhadap sel manusia, hewan, maupun tanaman.
Splenectomy as a Risk Factor for Graft Rejection Following Endothelial Transplantation: Retrospective Study
Authors: Kammrath Betancor Paola , Böhringer Daniel , Maier Philip , Lapp Thabo , Reinhard Thomas
Published: September 2024

Background

Anterior chamber–associated immune deviation (ACAID) is an active immunotolerance mechanism, which is induced by placing antigen into the anterior eye chamber as long as a major surgical trauma is avoided. For this reason, ACAID may be a major contributor to the favorable immunologic outcomes in Descemet membrane endothelial keratoplasty (DMEK). Rodent models have demonstrated the importance of a functional spleen for the development of an ACAID.

Objective

This study aimed to investigate whether splenectomy leads to increased rejection rates after DMEK in humans.

Methods

A retrospective evaluation was conducted on the course following DMEK at the Eye Center, Medical Center, University of Freiburg, for patients with a self-reported history of splenectomy compared to patients without this condition. Potential study patients were contacted by mail. A questionnaire to self-report splenectomy and the time thereof was sent out. The medical records of all consenting patients at the Eye Center were reviewed for graft survival and immune reactions.

Results

We asked 1818 patients after DMEK to report their history of splenectomy. A total of 1340 patients responded and were included in the study. Of these 1340 patients, 16 (1.2%) reported a history of splenectomy (ie, 26 DMEKs, with 10 patients being transplanted in both eyes and 6 patients being transplanted in 1 eye; median age at surgery 73.7, range 66.7-76.1 y). The remaining patients (1324 patients, ie, 1941 eyes) served as controls, with 1941 DMEKs (median age at surgery 71.5, range 64.1-77.2 y). Five (19%) out of the 26 eyes from the splenectomy group required a second transplant due to dislocation (n=2.8%), failure (n=2.8%), and rejection (n=1.4%). Kaplan-Meier analysis revealed no relevant difference compared with controls.

Conclusions

Our results suggest that splenectomy has no major effect on the outcome following DMEK. Subsequent, ACAID may not be the main reason for the favorable immunological outcomes in DMEK, or the camero-splenic axis may be subordinate in humans. However, we only included 16 patients who underwent splenectomy, so it might be possible that we missed a minor effect.
Real-World Outcomes of a Digital Behavioral Coaching Intervention to Improve Employee Health Status: Retrospective Observational Study (Preprint)
Authors: Abdul Aziz Amani Fadzlina , Ong Tiffanie
Published: September 2024

BACKGROUND

Chronic noncommunicable diseases (NCDs) account for major disability and premature mortality worldwide, with low- and middle-income countries being disproportionately burdened. Given the negative impact of NCDs on employee performance and work productivity, there is a rising need for stakeholders to identify effective workplace solutions that can improve employee health outcomes. As the workplace becomes more dispersed post pandemic, digital behavioral coaching offers a scalable, personalized, and cost-effective method of managing chronic disease risk factors among employees.

OBJECTIVE

This study aimed to retrospectively evaluate the impact of a digital behavioral coaching program on year-to-year changes in employee health status in a cohort of Indonesian employees.

METHODS

This retrospective real-world exploratory analysis of secondary health data followed 774 employees of an Indonesian company who completed company-sponsored health screenings between 2021 and 2022 and were given access to Naluri (Naluri Hidup Sdn Bhd), a holistic digital therapeutics platform offering digital behavioral health coaching and self-help tools. Participants were retrospectively classified as those who received active coaching (n=177), passive coaching (n=108), and no coaching (n=489). Linear mixed-effects models were used to evaluate the year-to-year changes in health outcomes across the 3 employee groups, with post hoc analyses evaluating within-group differences between the 2 time points and between-group differences at follow-up.

RESULTS

Significant time×group interaction effects were detected for body weight, BMI, hemoglobin A1c, low-density lipoprotein, total cholesterol, and systolic and diastolic blood pressure. Post hoc pairwise comparisons revealed significant improvements in hemoglobin A1c (mean difference [Mdiff]=–0.14, P=.008), high-density lipoprotein (Mdiff=+2.14, P<.001), and total cholesterol (Mdiff=–11.45, P<.001) for employees in the Active Coaching group between 2021 and 2022, with the other 2 groups reporting deteriorations in multiple health outcomes throughout the 2 time points. At follow-up, those who received active coaching between 2021 and 2022 reported significantly lower body weight (P<.001), BMI (P=.001), low-density lipoprotein (P=.045), and total cholesterol (P<.001) than the No Coaching group.

CONCLUSIONS

This study demonstrates real-world outcomes and implications supporting the use of workplace digital behavioral coaching in improving employee health status. Given the rising burden of NCDs in the Southeast Asian region, our findings underscore the role that workplace digital health interventions can play in preventing and managing chronic disease risk factors.

CLINICALTRIAL
The Impact of Air Pollution Information on Individuals’ Exercise Behavior: Empirical Study Using Wearable and Mobile Devices Data (Preprint)
Authors: Yang Yang , Goh Khim-Yong , Teo Hock Hai , Tan Sharon Swee-Lin
Published: September 2024

BACKGROUND

Physical exercise and exposure to air pollution have counteracting effects on individuals’ health outcomes. Knowledge on individuals’ real-time exercise behavior response to different pollution information sources remains inadequate.

OBJECTIVE

This study aims to examine the extent to which individuals avoid polluted air during exercise activities in response to different air pollution information sources.

METHODS

We used data on individuals’ exercise behaviors captured by wearable and mobile devices in 83 Chinese cities over a 2-year time span. In our data set, 35.99% (5896/16,379) of individuals were female and 64% (10,483/16,379) were male, and their ages predominantly ranged from 18 to 50 years. We further augmented the exercise behavior data with air pollution information that included city-hourly level measures of the Air Quality Index and particulate matter 2.5 concentration (in µg/m3), and weather data that include city-hourly level measures of air temperature (ºC), dew point (ºC), wind speed (m/s), and wind direction (degrees). We used a linear panel fixed effect model to estimate individuals’ exercise-aversion behaviors (ie, running exercise distance at individual-hour, city-hour, or city-day levels) and conducted robustness checks using the endogenous treatment effect model and regression discontinuity method. We examined if alternative air pollution information sources could moderate (ie, substitute or complement) the role of mainstream air pollution indicators.

RESULTS

Our results show that individuals exhibit a reduction of running exercise behaviors by about 0.50 km (or 7.5%; P<.001) during instances of moderate to severe air pollution, and there is no evidence of reduced distances in instances of light air pollution. Furthermore, individuals’ exercise-aversion behaviors in response to mainstream air pollution information are heightened by different alternative information sources, such as social connections and social media user-generated content about air pollution.

CONCLUSIONS

Our results highlight the complementary role of different alternative information sources of air pollution in inducing individuals’ aversion behaviors and the importance of using different information channels to increase public awareness beyond official air pollution alerts.
Automated Identification of Postoperative Infections to Allow Prediction and Surveillance Based on Electronic Health Record Data: Scoping Review (Preprint)
Authors: van der Meijden Siri Lise , van Boekel Anna M , van Goor Harry , Nelissen Rob GHH , Schoones Jan W , Steyerberg Ewout W , Geerts Bart F , de Boer Mark GJ , Arbous M Sesmu
Published: September 2024

BACKGROUND

Postoperative infections remain a crucial challenge in health care, resulting in high morbidity, mortality, and costs. Accurate identification and labeling of patients with postoperative bacterial infections is crucial for developing prediction models, validating biomarkers, and implementing surveillance systems in clinical practice.

OBJECTIVE

This scoping review aimed to explore methods for identifying patients with postoperative infections using electronic health record (EHR) data to go beyond the reference standard of manual chart review.

METHODS

We performed a systematic search strategy across PubMed, Embase, Web of Science (Core Collection), the Cochrane Library, and Emcare (Ovid), targeting studies addressing the prediction and fully automated surveillance (ie, without manual check) of diverse bacterial infections in the postoperative setting. For prediction modeling studies, we assessed the labeling methods used, categorizing them as either manual or automated. We evaluated the different types of EHR data needed for the surveillance and labeling of postoperative infections, as well as the performance of fully automated surveillance systems compared with manual chart review.

RESULTS

We identified 75 different methods and definitions used to identify patients with postoperative infections in studies published between 2003 and 2023. Manual labeling was the predominant method in prediction modeling research, 65% (49/75) of the identified methods use structured data, and 45% (34/75) use free text and clinical notes as one of their data sources. Fully automated surveillance systems should be used with caution because the reported positive predictive values are between 0.31 and 0.76.

CONCLUSIONS

There is currently no evidence to support fully automated labeling and identification of patients with infections based solely on structured EHR data. Future research should focus on defining uniform definitions, as well as prioritizing the development of more scalable, automated methods for infection detection using structured EHR data.
Acceptance, Safety, and Effect Sizes in Online Dialectical Behavior Therapy for Borderline Personality Disorder: Interventional Pilot Study (Preprint)
Authors: Vonderlin Ruben , Boritz Tali , Claus Carola , Senyüz Büsra , Mahalingam Saskia , Tennenhouse Rachel , Lis Stefanie , Schmahl Christian , Margraf Jürgen , Teismann Tobias , Kleindienst Nikolaus , McMain Shelley , Bohus Martin
Published: September 2024

BACKGROUND

The potential of telehealth psychotherapy (ie, the online delivery of treatment via a video web-based platform) is gaining increased attention. However, there is skepticism about its acceptance, safety, and efficacy for patients with high emotional and behavioral dysregulation.

OBJECTIVE

This study aims to provide initial effect size estimates of symptom change from pre- to post treatment, and the acceptance and safety of telehealth dialectical behavior therapy (DBT) for individuals diagnosed with borderline personality disorder (BPD).

METHODS

A total of 39 individuals meeting the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders [Fifth Edition]) criteria for BPD received 1 year of outpatient telehealth DBT at 3 sites in Germany and Canada. Effect size estimates were assessed using pre-post measures of BPD symptoms, dissociation, and quality of life. Safety was evaluated by analyzing suicide attempts and self-harm. Additionally, acceptance and feasibility, satisfaction with treatment, useability of the telehealth format, and the quality of the therapeutic alliance were assessed from both therapists’ and patients’ perspectives. All analyses were conducted on both the intention-to-treat (ITT) and according-to-protocol (ATP) samples.

RESULTS

Analyses showed significant and large pre-post effect sizes for BPD symptoms (d=1.13 in the ITT sample and d=1.44 in the ATP sample; P<.001) and for quality of life (d=0.65 in the ITT sample and d=1.24 in the ATP sample). Dissociative symptoms showed small to nonsignificant reductions. Self-harm behaviors decreased significantly from 80% to 28% of all patients showing at least 1 self-harm behavior in the last 10 weeks (risk ratio 0.35). A high dropout rate of 38% was observed. One low-lethality suicide attempt was reported. Acceptance, feasibility, and satisfaction measures were high, although therapists reported only moderate useability of the telehealth format.

CONCLUSIONS

Telehealth DBT for BPD showed large pre-post effect sizes for BPD symptoms and quality of life. While the telehealth format appeared feasible and well-accepted, the dropout rate was relatively high. Future research should compare the efficacy of telehealth DBT with in-person formats in randomized controlled trials. Overall, telehealth DBT might offer a potentially effective alternative treatment option, enhancing treatment accessibility. However, strategies for decreasing drop-out should be considered.

CLINICALTRIAL

German Clinical Trials Register DRKS00027824; https://drks.de/search/en/trial/DRKS00027824
Designing and Validating ‘Health Unit in Focus’: A serious Game for Enhancing Undergraduate education on Older Adults Health (Preprint)
Authors: Sousa Barbalho Yuri Gustavo , de Souza Silva Calliandra Maria , Silva Fernandes Carla , de Souza Lima Trombini Raíza Rana , Littig Melo Patrícia , Farias de Oliveira Aline , Martins Pereira Alayne Larissa , de Oliveira Silva Alessandro , Ramos de Lima Luciano , Morato Stival Marina , Moura Pinho Diana Lúcia , Schwerz Funghetto Silvana
Published: September 2024

BACKGROUND

Population aging underlines the critical need for improving health professional training to adequately care for older adults (over 60 years old).

OBJECTIVE

Develop and validate a serious game on older adult health for undergraduate nursing students.

METHODS

This quantitative and descriptive methodological study, conducted between February and December 2023 at a public university in the Federal District, involved the active participation of 27 8th-year undergraduate nursing students. The game, 'Unidade de Saúde em Foco' ('Health Unit in Focus'), was developed and validated with their input. It features 75 clinical cases distributed across three themes: pharmacology, metabolic syndrome, and semiology. The application was validated using the SUS, and the students' feedback.

RESULTS

Of the 40 students initially enrolled, 27 completed the study. The game received an average SUS score of 85.75 (median: 86.57), classified as excellent—all evaluated items scored above 75. Participants considered the game easy to use, accessible, practical, and rich in well-founded, useful content. This high usability score, coupled with the overwhelmingly positive feedback from the students who found the game easy to use, accessible, practical, and rich in well-founded, useful content, instills confidence in the game's effectiveness. Furthermore, 100% of students agreed that learning through games is effective and expressed interest in incorporating more interactive games into their training.

CONCLUSIONS

The Serious Game' Unidade de Saúde em Foco' ('Health Unit in Focus') is not just a valid and reliable tool for training nursing students, but also an engaging and interactive approach to learning. Its ability to captivate and involve students in the learning process is a testament to its potential to revolutionize nursing education.
Direct sowing-Alternate Method of Transplanting Rice
Authors: Devi Dr. M. Ganga , Kumar Dr. M. Yugandhar , Meera Dr. Shaik. N.
Published: September 2024

Rice (Oryza sativa) is the major food crop in terms of production and economy and grown in all ecological regions of India. Rice is cultivated traditionally through transplanting of 20-25 days old seedling in the country. Due to unavailability of suitable technology for rice cultivation, there is a huge yield gap in rice production. Country has made target of self-sufficiency in rice production. This target can be achieved through adoption of Direct seeded rice cultivation technology of rice cultivation which also helps to adapt in the climate change scenario. Due to issues of water scarcity and expensive labour, direct seeded rice cultivation technology is adopting worldwide. To study the direct sowing of rice to overcome the difficulty of scarce and costly labor in transplanted rice, KVK Guntur has conducted an OFT in Guntur district. The study was carried out in two villages of Guntur district namely Morampudi and Kanteru villages in the years 2019-20 and 2020-21. From each selected village, 5 farmers practicing DSR and 5 farmers practicing Conventional Transplanting method during the same season were selected. The average yield was considerably high in TR (67 qtl/ha) compared to DSR (66 qtl/ha) method of cultivation. The total cost of cultivation in DSR was estimated to be Rs.47,000 per hectare. The total cost of cultivation in TR was estimated to be Rs. 53,000 per hectare. DSR with suitable conservation practices has potential to produce slightly lower or comparable yields as that of TPR and appears to be a viable alternative to overcome the problem of labor and water shortage. Despite controversies, if properly managed, comparable yield may be obtained from DSR compared with TPR.
Educación, Estado y religión en el Diario de los Niños (1839-1840)
Authors: Soriano Salkjelsvik Kari
Published: September 2024

Este trabajo se centra en el Diario de los Niños (1839-1840), primera publicación periódica infantil moderna de México. Aunque estudios anteriores lo han situado en el contexto de la formación de México como nación emergente, destacándolo como manifestación de los pensamientos liberales imperantes sobre la ciencia y educación de la época, este artículo propone una interpretación más matizada. Se argumentará que las tendencias liberales católicas evidentes en esta publicación, particularmente aquellas que abogan y promueven los roles sociales de la fe cristiana, son esenciales para entender la formación del niño como sujeto social y la importancia otorgada a la religión en la sociedad durante las convulsas décadas de 1830 y 1840. Se prestará especial atención a los textos que fomentan visiones religiosas y morales comunitarias.
Agustín Yáñez y la revista Bandera de Provincias
Authors: Olea Franco Rafael
Published: September 2024

En mayo de 1929 empezó a circular, desde la ciudad de Guadalajara, Bandera de Provincias, revista cuya idea original se gestó en la casa del joven escritor Agustín Yáñez (1904-1980), donde solían reunirse los cinco miembros fundadores de la publicación. Su subtítulo, Quincenal de Cultura, marca tanto su periodicidad como sus amplios intereses, en diferentes expresiones: literatura, artes gráficas, música, cinematografía, cultura popular, etc. Sin ningún mecenazgo, ni particular ni gubernamental, alcanzó a publicar —en el lapso de un año y en formato tabloide— 24 números y 2 suplementos. Como su nombre indica, esta revista fue un loable intento por promover la cultura desde diversos ámbitos de las provincias mexicanas, en lugar de esperar que el centralismo de Ciudad de México las proveyera con materiales culturales. A cien años de distancia, la “bandera” que desplegaron puede leerse hoy como una muestra palpable de la diversidad cultural mexicana.
“De la rareza como una de las bellas artes”. Los raros y los otros (autores y ediciones)
Authors: Zavala Díaz Ana Laura
Published: September 2024

Reseña de Los raros y los otros (autores y ediciones). Coordinación y edición de Pablo Mora. México: Universidad Nacional Autónoma de México, Instituto de Investigaciones Bibliográficas, 2023, 352 p., il. ISBN: 978-607-30-7210-6.
Gender and the Gig Economy: An Analysis of Women Workers across Gig Platforms
Authors: Bansal Tarun , De Dr. Swarita
Published: September 2024

The expansion of gig economy was seen with short term, flexible work along with the benefit of digital platforms, all these have brought in new opportunities for people. The main idea of the passage is to explore participation, the hindrances and the discrimination they must go through It also studies the issues and societal factors contributing to the "missing women" phenomenon in India. The research paper uses secondary data and a more qualitative approach along with some analytical tools such as linear regression, and chi-square to test the hypotheses and find conclusions. The analysis concludes that women are often disregarded in the gig platforms and tend to engage in lower paying jobs with lesser flexibility for them. Additionally, women experience unequal pay, unstable job, and lesser of benefits in the gig economy. With respect to the "missing women" phenomenon in India, the study explores behavioural factors such as son preference, gender inequality practices. By finding the gaps and challenges faced by women, which are often ignored, this study aims to inform policies and practices that can help women overcome obstacles, promote gender equality, and create a more inclusive and equitable gig economy.
Biodiversity of Seoni District: Challenges of Conservation and Efforts towards Sustainable Development
Authors: Neeleshwari Ku , Chauhan Sanjay Singh
Published: September 2024

िसवनी िजला, मȯ Ůदेश का एक समृȠ जैव-िविवधता वाला Ɨेũ है, िजसमŐिविभɄ Ůकार के वɊजीव, वन˙ितयाँ, और पाįरİ̾थितक तंũ शािमल हœ। यह Ɨेũ न के वल पाįरİ̾थितकी तंũ सेवाओंमŐमहȕपूणŊभूिमका िनभाता है, बİʋ ̾थानीय समुदायो ंकी आजीिवका और सांˋृ ितक धरोहर का भी अिभɄ िहˣा है। हालांिक, िपछलेकु छ दशको ंमŐमानवजिनत गितिविधयो ं, जैसेवनो ंकी कटाई, अवैध िशकार, और कृ िष िवˑार, नेइस Ɨेũ की जैव-िविवधता को गंभीर खतरेमŐडाल िदया है। िसवनी िजलेमŐ1990 से 2020 के बीच वनो ंकी कु ल 15% कटौती Šई है, िजससेवɊजीवो ंके Ůाकृ ितक आवासो ं मŐभारी कमी आई है। इस शोध मŐिसवनी िजलेकी जैव-िविवधता के संरƗण के िलए िकए गए Ůयासो ंका िवʶेषण िकया गया है। पŐच राʼŌ ीय उȨान और अɊ संरिƗत Ɨेũो ंकी ̾थापना के माȯम सेसंवेदनशील Ůजाितयो ंके संरƗण के Ůयास िकए गए हœ। इसके अलावा, ̾थानीय समुदायो ंको संरƗण के महȕ के Ůित जागŝक करनेके िलए िविभɄ कायŊŢम चलाए गए हœ। Ůकृ ित आधाįरत पयŊटन को भी बढ़ावा िदया जा रहा है, जो सतत िवकास का एक साधन सािबत हो सकता है। उदाहरण के िलए, 2023 मŐपŐच राʼŌ ीय उȨान मŐपयŊटको ंकी संƥा मŐ20% की वृİȠ Šई, िजससे̾थानीय अथŊʩव̾था को भी लाभ पŠंचा। पįरणामˢŝप, इन Ůयासो ंसेजैव-िविवधता के संरƗण मŐकु छ सकाराȏक Ůभाव देखनेको िमलेहœ, जैसेिक बाघो ंकी संƥा मŐ10% की वृİȠ, लेिकन अभी भी कई चुनौितयाँबनी Šई हœ। सतत िवकास के लƙो ंको Ůाɑ करनेके िलए सामूिहक और समİɋत Ůयासो ंकी आवʴकता है। यह शोध िसवनी िजलेकी जैव-िविवधता को संरिƗत करने और उसेसतत िवकास की िदशा मŐलेजानेके िलए ठोस रणनीितयो ंका Ůˑाव देता है।
Kebijakan Keimigrasian Untuk Menyederhanakan Birokrasi, Mempermudah Dan Mempercepat Layanan Izin Tinggal
Authors: Ida Ayu Gita Dehardha  , I Made Arjaya  , Luh Putu Suryani
Published: September 2024

Dalam suatu negara pastinya terdapat perseberan penduduk yang datang dari berbagai daerah dengan maksud untuk mencari tempat tinggal maupun pekerjaan. Dalam konteks ini peran imigrasi sangat mempunyai peran yang sangat vital dalam mengatur serta mengurus legalitas tinggal pada suatu daerah ataupun kawasan. Berdasarkan latar belakang maka timbullah beberapa rumusan masalah antara lain: Apa yang menjadi dasar pertimbangan Surat Edaran Nomor IMI-0702.GR.01.01 Tentang Kebijakan Keimigrasian Untuk Menyederhanakan Birokrasi, Mempermudah dan Mempercepat Layanan Izin Tinggal Guna Mendukung Kebijakan Peningkatan Investasi Asing Ke Dalam Negeri tersebut diterapkan? dan bagaimana keabsahan Surat Edaran dimaksud?. Sehingga maksud tujuan dilakukannya penelitian ini yaitu untuk mengetahui dasar pertimbangan sehingga surat edaran dimaksud diberlakukan dan untuk mengetahui bagaimana keabsahan surat edaran dimaksud. Metode penelitian yang digunakan adalah metode hukum normatif. Dengan bentuk penelitian hukum secara normatif dengan konseptual dan undang-undang secara Analisa hukum. Hasil survei mengindikasikan Dasar pertimbangan surat edaran dimaksud didasari atas tindak lanjut atas instruksi Presiden Republik Indonesia.
Kepemilikan Tanaman Koka oleh Rumah Sakit untuk Tujuan Medis Ditinjau dari Undang-Undang Nomor 35 Tahun 2009
Authors: I Nyoman Trian Prananta Wibawa  , I Nyoman Gede Sugiartha  , I Made Minggu Widyantara
Published: September 2024

Hak asasi manusia (HAM) yang paling penting dalam kehidupan manusia adalah hal kesehatan yang kemudian juga pengaturannya tertera pada konstitusi Indonesia serta sangat fundamental. Adapun hal-hal yang menjadi ancaman besar sehingga bisa memberikan ancaman yang serius bagi kesehatan manusia yaitu penyalahgunaan narkotika dengan menciptakan berbagai macam efek bagi tubuh seseorang yang telah mengonsumsi nya. Narkotika di Indonesia harus menjadi serta mendapatkan perhatian khusus bagi dari pemerintah maupun dari masyarakat. Penelitian yang akan dilakukan yaitu mengenai aturan-aturan hukum tanaman koka pada suatu Rumah Sakit yang bertujuan unutk medis serta mengenai kedudukan terhadap rumah sakit yang memiliki serta memanfaatkan tanaman koka bagi penyembuhan pasien. Penulis dalam hal ini menggunakan penelitian hukum normatif sebagai penunjang penelitian. Sebagaimana Narkotika telah diatur dalam UU Nomor 35 Tahun 2009 yang dijadikan acuan oleh berbagai macam aspek dan institusi dalam hal pemanfaatan nya, kemudian Narkotika dalam dunia kesehatan juga telah memiliki acuan yaitu pada Keputusan Menteri Kesehatan Nomor 1999/MenKes/SK/X/1996 yang juga menjadi regulasi agar tujuan pengawasan narkotika dapat dilakukan dengan mudah.
Implikasi Pengurangan Pemakaian Plastik Sekali Pakai Terhadap Volume Sampah di TPA Suwung
Authors: I Gusti Made Yudha Pramana  , I Nyoman Gede Sugiartha  , Luh Putu Suryani
Published: September 2024

The waste problem in Indonesia is getting worse, including the problem of landfills in Bali getting full every day. The waste problem is not only a matter for the government, but also for the community. The use of single-use plastics is an important thing that must be considered to find the best solution. This research aims to find out the legal policies that can help overcome the waste problem in Indonesia in general and Bali in particular. Based on this, this research will discuss how the impact of reducing the use of single-use plastics on the environment, society and its relation to storage in Suwung landfill and how the government's efforts as a policy maker in overcoming the problem of single-use plastic waste in Suwung landfill. The research method used is an empirical legal research method that uses a fact-based approach and analyzes legal concepts through social problems. The results obtained from this research are that the reduction in the use of single-use plastics provides a solution to the waste problem at Suwung Landfill so that less waste enters and if the reduction in the use of single-use plastics is applied more widely, plastic waste generation can be minimized, and regulations made by the government emphasize solutions from various aspects of the waste problem. However, many people still violate the regulations in the field.
Perlindungan Konsumen Pengguna Jasa Parkir Atas Pelepasan Tanggung Jawab Pelaku Usaha Parkir Menerapkan Klausula Baku dalam Mencapai Keadilan Berkontrak
Authors: Pradnyandari Ida Ayu Anggita , Mahendrawati Ni Luh Made , Wesna Putu Ayu Sriasih
Published: September 2024

The Consumer Protection Act 0.8 of 1999 contains provisions regarding the rights and obligations that consumers and business actors have. For example, consumers who have not received legal justice in standard agreements that create business actors, seeing the phenomenon that occurs, namely agreements made by parking business actors for consumers who use parking services, basically to meet the needs of a significant number of consumers, to make it easier for parking business actors, agreements that made for consumers who use parking services to be printed in bulk in the form of standard clauses contained in parking tickets that are made unilaterally. However, this authority contains the potential for fraud for parking business actors through the existence of a clause that is not permitted. The contents of this clause are based on the UUPK which is a clause that contains the loading of the responsibility of the businessperson for the consumer which is contained under Article 18 paragraph 1. From this it can be said that there are still many parking business actors who, in stipulating standard clause agreements in the form of parking tickets, violate the provisions of the Protection Act. Consumers are related to the discrepancy of the clause in UUPK to obtain contractual justice for consumers. With the existence of an agreement that uses the standard clause it is not allowed so that the legal consequences according to the explanation of Article 18 paragraph 3 UUPK are null and void.
Efektifitas Perda Nomor 5 Tahun 2021 Tentang Pengelolaan Sampah Rumah Tangga dan Sampah Sejenis Sampah Rumah Tangga Di Kota Tabanan
Authors: Ariskayanti Ida Ayu Made , Wijaya I Ketut Kasta Arya , Suryani Luh Putu
Published: September 2024

The problem of waste is a problem that never ends from year to year. The volume of waste always increases every year and causes various negative impacts on the environment and the sustainability of people's lives. The population is affected by the increase in waste volume. With this background, the problem formulation raised is how the implementation of Tabanan Regency Regional Regulation Number 5 of 2021 concerning Waste Management in Tabanan City, and how the effectiveness of Tabanan Regency Regional Regulation Number 5 of 2021 in Tabanan City. This research uses empirical legal research type, data collection techniques in this research are by conducting interviews and document studies. The results of the study found that Tabanan Regency Regional Regulation Number 5 of 2021 concerning Management of Household Waste and Waste Similar to Household Waste has been implemented quite well but has not been fully effective because there are still several obstacles in the implementation of the regulation, namely low awareness and knowledge of waste management and lack of facilities and infrastructure in managing waste. Sanctions against waste violators are subject to administrative sanctions in the form of verbal and / or written warnings, as well as fines.
Perlindungan Hukum Terhadap Konsumen Jasa Titip Online Dalam Hal Terjadinya Cacat Produk
Authors: Kaze Kadek Bramanta Rudi , Budiartha I Nyoman Putu , Suryani Luh Putu
Published: September 2024

The development of the online shopping system has given rise to new business opportunities, one of which is known as a buying and selling service. One of the risks for users of ticketing services is the danger of defects in products received by users of online ticketing services. Based on this, what is the legal protection form of consumers of online ticketing services in the event of a defect in the product received? And how are online delivery service business actors responsible for losses received by consumers for defective goods products. This research uses a normative type of legal research. There are two forms of legal protection for consumers of online ticketing services in the event of product defects received through online buying and selling services, namely preventive and repressive legal protection which can be seen in the provisions of the UUPK. The responsibility of online delivery service business actors for losses received by consumers for defective goods products, in addition to rights and obligations, there are also responsibilities that must be carried. This responsibility is part of a binding obligation in the activities of running a business.
Synthesis and Evaluation of Aldehyde Derivatives of Sulfonyl Chloride Quinoxaline
Authors: Goyal Rakesh , Sharma Mukesh , Ahuja Dharmendra , Jain Anurekha
Published: September 2024

In pyrazine mesomeric interaction between the protonated & neutral nitrogen atoms probably destabilizes the cation.N, N’-diprotonation is very easier for pyrazine Synthesis of 2, 3-diphenylquinoxaline by phenylene-diamine in 16 ml of rectified spirit was added & combine solution was warm in water bath for 30 min. added water until slight colorless persist & allow to cool recrystallize the product in ethanol.   Synthesis of 2, 3-diphenylquinoxaline 7-sulfonylchloride (R) using chlorosulfonic acid under ice-cold condition, then Synthesis of  2-hydroxyphenyl-2,3-diphenylquinoxaline-7-sulphonate(R1) throughresorcinol with 3ml pyridine & sulphonyl chloride derivative, Synthesis of 2-formylphenyl-2,3-diphenylquinoxaline-7-sulphonate(R7)obtained by reaction of salicylaldehyde with pyridine & sulphonyl chloride derivative then Synthesis of 3-formylphenyl-2,3-diphenylquinoxaline-7-sulphonate(R9) obtained by heating on water bath mixture of3-hydroxybenzaldehyde with pyridine & sulphonyl chloride, Synthesized quinoxaline derivatives were subjected to antimicrobial susceptibility testing by well diffusion method against gram positive (S.aureus, 2079) and gram negative bacteria (E. coli, 2685). The results of quinoxaline derivatives in terms of zone of inhibition recorded. MIC of quinoxaline derivative was determined by tube micro dilution technique against S. aureus and E. coli. The turbidity was measured by UV at about 420 nm. Hydrogen peroxide scavenging activity and 1, 1 diphenyl 2, picryl hydrazyl Method (DPPH) calculated and Most of the derivatives have shown comparable antioxidant activity in relation to standard Ascorbic acid and DPPH. 
Keywords: QSAR, Sulfonyl Chloride Quinoxaline, Ant-microbial, Antioxidant
PREPARE AND EVALUATE MUCOADHESIVE FORMULATIONS OF LAMIVUDINE WITH BETTER CONTROLLED/ SUSTAINED DRUG RELEASE PROFILE
Authors: Rathore Kavita , Tyagi C.K. , Pandey Harish , Shah Sunil Kumar
Published: September 2024

The aim of present study was to formulate & evaluate the mucoadhesive sustained release formulations of lamivudine and to fulfill this aim, two mucoadhesive formulations Gels and Tablets were prepared by using three different polymers: HPMC K15, poloxamer 407 & carbopol 934. Three mucoadhesive gel and nine tablet formulations were prepared and evaluated for various parameters. All three gels were able to give sustained release up to 12 hours. Tablet formulations, F1 to F5 failed to fulfill the aim. Only F6, F7, F8 & F9 formulations were selected, as all gave sustained release up to 12 hours, except F6, which gave sustained release profile only till 7 hours. From the drug release plots, it was concluded that the type of polymer and concentration of polymer have distinct effect on in vitro drug release profile and all the formulations follow first order mechanism with anomalous diffusion or non-fickian diffusion, except carbopol gel and poloxamer tablets. Carbopol gel follows zero order release rate with super case II transport and poloxamer tablets (F6) follow higuchi with non-fickian diffusion. It is concluded that mucoadhesive formulations of lamivudine can be prepared for sustaining its release. And the successful outcome of the present study also encourage for further studies to assess the ability of the mucoadhesive formulations of lamivudine in providing an effective sustained and safe therapy for AIDS.
Synthesis and Biological Evaluation of 1-(6-chlorobenzo [d]thiazol-2-yl)-2-(disubstituted methylene) hydrazine derivatives
Authors: Sharma Neetesh Kumar , Bhadauria Raghvendra Singh
Published: September 2024

Synthesis of a series of various 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(disubstitutedmethylene)hydrazine derivatives (7a-7e)have been done. Synthesis of a series of intermediates (3 and 5) have been also done, 6-Chloro-2-amine-1,3-benzothiazole (3), 2-hydrazino-6-chloro-1, 3-benzothiazole (5) and final product (7a-7e), 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(diphenylmethylene) hydrazine (7a), 1-(6-chlorobenzo [d]thiazol-2-yl)-2-(propan-2-ylidene) hydrazine (7b), (E)-2-(butan-2-ylidene)-1-(6-chlorobenzo[d]thiazol-2-yl)hydrazine (7c), (Z)-1-(6-chlorobenzo[d]thiazol-2-yl)-2-(cyclohexylmethylene) hydrazine (7d), 2-(6-chlorobenzo[d]thiazol-2-yl)-1-(7,7- dimethylbicyclo [2,2,1] heptan-2-ylidene)hydrazine (7e). Spectral analysis of all intermediates and final products has been done by IR and NMR. After spectral analysis, antibacterial activity has been screened against S. aurius and E. coli bacterias.
Synthesis, Characterization and Evaluation of Anticancer Activity of Nanoresveratrol in B16 Melanoma Cell Line
Authors: Arora Reena , Parkash Chander
Published: September 2024

Resveratrol, a member of the stilbene family, is a naturally occurring polyphenolic compound in grapes and other botanicals. It carries a potential to prevent or treat several chronic diseases, including cancers. Despite various promising health benefits, including chemopreventive and chemotherapeutic benefits against cancer, clinical translation of resveratrol is hampered due to its poor bioavailability, solubility and stability. Here we present the study to prepare nano-formulation of resveratrol for improving the resveratrol profile. Calcium phosphate loaded nanoresveratrol has been synthesized, characterized and its anti-proliferative effects were examined in a B16 murine melanoma cell line. The anti-cancer effects of nanoresveratrol were directly compared with free resveratrol and chemotherapy drug 5-FU. Nanoresveratrol induced apoptosis in B16 melanoma more efficiently as compared to resveratrol alone and 5 FU. A nuclear staining profile following Hoechst staining of B16 cells is indicative of apoptosis and shows that the anti-cancer effect of nanoresveratrol is due to apoptosis induction. Since antioxidant activity is a hallmark of resveratrol, we also measured the biochemical antioxidant activities of superoxide dismutase (SOD) and catalase antioxidant enzymes. We found that, concurrent with the anti-cancer activity, the antioxidant activity of nanoresveratrol increased. Collectively, these findings clearly show that nanoresveratrol is superior to free resveratrol in suppressing cell growth in B16 murine melanoma cell line, and that the anti-cancer activity is primarily through apoptosis induction.
Keywords:  Resveratrol, Nanoresveratrol, Formulation, B16 cell line, Cancer, Melanoma, Chemopreventive, Chemotherapeutic
A Review on Evaluation Parameter for Moringa oleifera Flower as Potent Anti-Diarrhoeal Activity
Authors: Sharma Om Prakash , Sharma Yogesh Kumar
Published: September 2024

The fresh flower of Moringa oleifera were collected from geographical sources, Qualitative analysis by physicochemical test were performed, Analytical Parameter will be perform as Ash Values, total ash value, acid insoluble ash value, water soluble ash value, extractive Values, loss on drying according to given methods, then extraction and fractionation by appropriate method and isolated the phytoconstituents further go for evaluation purpose by castor oil-Induced model and data will analyze by one-way ANOVA.
Keywords: Moringa oleifera, anti-diarrheal activity, castor oil-Induced model and Moringa.
Preliminary Phytochemical and GC-MS Analyses of Methanolic Extract of Blechnum orientale L. Collected From Kothiyar, Kanyakumari District, Tamil Nadu, India
Authors: Fredrick Raja E , John Peter Paul J
Published: September 2024

The aim of the study was to screen the phytochemicals of methanolic extract of Blechnum orientale L. collected from Kothiyar, located in Kanyakumari district, Tamil Nadu, India. The preliminary phytochemical analysis was carried out by Harborne method, followed by GC-MS analysis. In the preliminary phytochemical analysis of Blechnum orientale L., the presence of twelve different types of secondary metabolites such as alkaloids, anthocyanin, anthraquinones, cardiac glycosides, coumarin, diterpenes, emodins, flavonoids, saponins, steroids, tannins and triterpenoids were reported in methanolic extract. GC-MS spectrum of methanolic extract of Blechnum orientale L. showed 20 different major peaks which indicated the presence of 20 compounds. The prevailing compounds in methanol extract were toluene (1.927min), thiazole, 4,5-dihydro-2-methyl- (2.249min), ethylbenzene (2.466min), benzene, 1,3-dimethyl- (2.523min), phosphine, acetyldimethyl- (2.684min), guanethidine (4.584min), 2-propanamine, n-methyl-n-nitroso- (5.303min), 4h-pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- (5.435min), diethylene glycol hexyl ether (6.333min), 2,2-dimethylpropanoic acid, nonyl ester (6.655min), 8-thiabicyclo[3.2.1]oct-2-ene (7.156min), 4h-pyrazole, 3-tert-butylsulfanyl-4,4-bistrifluoromethyl- (9.217min), 1,3-benzenediol, 4-propyl- (11.250min), cyclohexanone, 2-methyl-5-(1-methylethenyl)- (13.775min), 2,4-hexadienal, (E,E)- (14.210min), n-hexadecanoic acid (14.966min), phytol (16.451min), 2(1h)-naphthalenone, octahydro-4a-methyl-7-(1-methylethyl)-, (4a.alpha.,7.beta.,8a.beta.)- (16.602min), 7-pentadecyne (16.659min) and 1,4-bis (trimethylsilyl) benzene (20.186min) respectively.
Keywords: Phytochemicals, Pteridophytes, GC-MS, Blechnum orientale, NIST
Novel UV Spectrophotometer Methods for Quantitative Estimation of Concensi (Amlodipine 10mg and Celecoxib 200mg) Using Hydrotropic Solubilizing Agents
Authors: Kushwaha Durga , Diwakar Sunil , Roy R. K. , Karole Sarita , Kushwaha Hemant , Jain Prabhat
Published: September 2024

Two simple, accurate, novel, safe and precise methods were developed for the simultaneous estimation of poorly water-soluble drugs Amlodipine besylate (AMD) and Celecoxib (CLX) in a in-house formulation using 2M sodium benzoate as a hydrotropic solution. AMD and CLX show maximum absorbances at 243 and 255 nm, respectively. Sodium benzoate did not show any absorbance above 225 nm and thus no interference in the estimation of drugs was seen. AMD and CLX follow Beer’s law in the concentration range of 2-10mg/ml and 10-50mg/ml (r2 = 0.9992 and 0.9995). Method-A employs the simultaneous equation method using 243 and 255 nm as two analytical wavelengths; method-B employs the absorption ratio method, which uses 243 and 250nm as two analytical wavelengths for estimation of AMD and CLX. The mean percent label claims of in-house formulation were found to be 98.74± 0.912and 99.22± 1.012in method-1, 97.89± 0.872and 99.49± 0.903 in method 2 for AMD and CLX, respectively. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values therefore both methods can be used for routine monitoring of AMD and CLX in industry in the assay of bulk drug and pharmaceutical formulation.
Keywords: Amlodipine besylate, Celecoxib, Simultaneous equation method; Absorption ratio method, Hydrotropic solubilizing agents