bluuebunny/crossref_metadata_2025 huggingface dataset:
Sentinel lymph node biopsy in patients with breast cancer. Experience in implementing at the regional level. Priority issues
Authors: Vorontsov A. Yu. , Volodin A. N. , Kurochkina M. A. , Radovskiy V. V. , Burova T. V. , Gamayunov S. V.
Published: October 2023

Background. Despite the fact that sentinel lymph node biopsy (SLNB) in breast cancer patients has become a routine diagnostic procedure, it is still of great interest to researchers, since the priority issues of choosing methodology, equipment, technology, and stages of use are still being discussed. Although all obstacles to this technique implementation into routine clinical practice have been eliminated, SLNB in locally advanced breast cancer is still rarely used. We describe the experience of implementing SLNB in Nizhny Novgorod Regional Clinical Oncology Dispensary. We also discuss organizational, tactical, and practical approaches aimed to minimize the number of errors in technical terms, as well as to choose a multidisciplinary approach to the development of regulations for the examination and treatment of patients with locally advanced breast cancer.

Aim. To assess the efficacy of SLNB implementation for patients with locally advanced breast cancer at the regional level.

Materials and methods. This study included 500 patients with invasive (T1–2) breast cancer with clinically negative sentinel lymph nodes of all immunohistochemical subtypes that had undergone SLNB and histological examination. Sentinel lymph nodes were visualized using the radioisotope colloid 99mTc-Nanotop. We present the implementation algorithm for this procedure into routine clinical practice and evaluate short-term results.

Results. A total of 500 patients have undergone SLNB. The first 30 cases were considered pilot cases, where all patients positive for sentinel lymph nodes additionally underwent standard axillary lymph node dissection. We observed a 100 % concordance of histological results. Then the surgery was routinely performed for all patients from this category. The assessment of short-term surgical outcomes demonstrated significant improvement of the postoperative period, reduced frequency of postoperative complications (persistent seroma of the axillary area to 2.85 %), reduced length of hospital stay (by 52.7 %) and improved functional and aesthetic results in the majority (>62 %) of patients.

Conclusion. Our algorithm of SLNB use in patients with breast cancer in routine clinical practice at the regional level allows for rapid method implementation, reduced length of hospital stay, better functional and aesthetic results, and lower incidence of persistent seroma of the axillary area.
Socio-psychological Personality Traits of a Deviant Parent (Based on the Material of Convicts)
Authors: Pestikova E.V.
Published: October 2023

The article is prepared on the basis of the results of the final qualifying work and is devoted to the analysis of psychological characteristics of the individual, including a tendency to deviant behavior and the life experience of parents who lead to violent actions against their own children. The sample was made up of convicts who committed crimes of child abuse (physical, emotional, psychological, sexual violence). The article analyzes the causes of parents' deviant behavior, clarifies aspects of deviant behavior, and considers individual life scenarios. The results obtained during the psychodiagnostic study revealed that violations of the relationship between a child and a parent when applying physical punishment measures in the family are more common for subjects prone to deviant behavior. A special role in the formation of the psyche of convicted parents was played by psychological trauma suffered in childhood or in adulthood as a result of sexual violence.
A STUDY ON THE PENDENCY OF CASES IN INDIAN COURTS vis-à-vis HUMAN RIGHTS
Authors: Ashish Sharma
Published: October 2023

In a progressive and developing society, one of the sound principle of the criminal justice system is that “Justice delayed is justice denied’.  The delay in dispensation of justice adversely affects the two important fundamental rights which are, right to access justice and the rule of Law.  Both are the part of the Indian Constitution.  In various decisions, the Indian Supreme Court has under scored the importance of expeditious trial.  Right to speedy trial is one of the facets of the Right to life and personal liberty under Article 212 of the constitution of India.  According to the Ministry of law, there are nearly five crore cases are pending as of now in courts3.  India is on the top in pending of cases across the globe.  In spite of the establishment of the tribunals, the situation of pendency is becoming worse.  There are various reasons which can be attributed to the situation of pendency of cases.  Among them some are; awareness of the legal rights by the people, emergence of new ways of access to justice such as RTI and PIL, inadequate number of judges in courts.  Government needs to take initiative in controlling the backlog of cases so that time justice could be imparted to all segments of the society. In present time, the pendency of cases is directly connected to the issue of human rights.  Pendency of a case in the court of law endangers numerous human rights. This research paper attempts to examine the various loopholes which leads to the pendency of cases in Indian courts and violates the human rights
Morphological Traits and Nuclear Genetic Diversity of Coptis sp. in Hoang Lien National Park, Lao Cai Province, Vietnam
Authors: Nguyen Hoang  , Nguyen Thanh Nhung  , Nguyen Thi Ngoc Minh  , Vuong Thi Huyen Trang  , Khuat Huu Trung  , Tran Dang Khanh  , Hoang Van Hung
Published: October 2023

Coptis is a medicinal plant genus in the Ranunculaceae family, and is also known as “Hoang Lien” in Vietnamese. It is a perennial herb that grows in some regions of the world. However, Coptis is endangered and faces global threats. This study aimed to characterize some main morphological characteristics and performed a phylogenetic analysis of 11 samples of Coptis sp. collected from Hoang Lien National Park using nuclear DNA sequence analyses. All sample species have unique morphological traits with distinct yellow rhizomes and basal leaves with five segments. The petiole measures 13-25 cm and is smooth, while the leaf blade is ovate, ranging from 7 to 15.5 cm in length and 5.5 to 14 cm in width. The leaves are subleathery, glabrous on the underside, and sparsely puberulous on the veins on the upper side. The molecular characterization of Coptis sp. genotypes was determined by ITS markers. The length of the ITS1-ITS2 sequences varied from 363 to 371 nucleotides. The average nucleotide composition was 17.11% A, 31.25% C, 32.247% G and 19.41% T, respectively. The comparison with the GenBank database showed that the samples had 95.71- 96.37% similarity with the species Coptis quinquesecta. The genetic distance among the 11 Coptis samples fluctuated from 0.00 to 0.017. A neighbor-joining tree was constructed to show the genetic relationships among Coptis samples. The results indicated that this endangered species had low levels of genetic diversity. The study has provided valuable information for genetic-based conservation of this rare endemic species and suggested some conservation strategies.
AUTONOMOUS UNMANNED DRONES FLIGHT PLANNING, USING A MODIFIED SHORTEST PATH ALGORITHM WITH A LIMITED TIME FRAME
Authors: Sondors Marks , Apeināns Ilmārs , Kodors Sergejs
Published: October 2023

The aim of this work is to develop an algorithm to find the shortest path for drone flight planning with a limited time frame. Author used the local search shortest path algorithm to find the most efficient algorithm to use for further modification to apply to a drones flight calculation. The algorithm was modified to use the distance between points as a unit of time to limit the flight path length depending on the drone's maximum flight time. As a result of the work, an algorithm was created which, upon receiving an array of points, finds the shortest distance between the points, but when it reaches the limit of the flight duration, it returns to the drone station to charge, and resumes flight once it’s done charging.
TRAINING OF A CONVOLUTIONAL NEURAL NETWORK FOR HAND GESTURE RECOGNIZING ON THE KAGGLE ASL ALPHABET DATASET
Authors: Vituškins Gļebs , Kodors Sergejs
Published: October 2023

Nowadays, hand gesture recognizing is important topic. It is used in virtual assistant work, for sign language translation, in virtual and augmented reality applications, and in entertainment services. The paper deals with the convolutional neural network training using different technologies. The neural network is trained to classify American manual alphabet and 3 extended gestures using photographs. The open access dataset Kaggle ASL Alphabet was used for training. Kaggle ASL Alphabet provides 87000 images of 29 classes for image classification and hand gesture recognizing.
Gastric duplication Cyst in a Child - An insight
Authors: Nikumbh Dhiraj B , Singhavi Sudhir , Nikumbh Roopali D
Published: October 2023

Gastric duplication cyst is uncommon congenital anomaly in paediatric population with an incidence rate of 17 per million populations. Its diagnosis and treatment is challenging in infants and children for both the clinicians and the pathologists. Most of the cases, diagnosis is rendered on laparotomy followed by histopathology as could not be possible on clinical and imaging studies alone due to its varied presentation.

The aim of this editorial is to highlight the morphology and rarity of gastric duplication cyst in children as less than 50 reported cases were available in literature.
A rare case of actinomycosis in routine fnac of the face in a tertiary care center in Central India
Authors: Singh Puja , Singrol Meena , Gangwani Amar
Published: October 2023

Actinomycosis is a chronic suppurative bacterial infection. It is caused by gram-positive, non-acid fast, filamentous, anaerobic to microaerophilic bacilli. Actinomycosis on the root of the nose is a rare entity. We report a case of 38 years old male who presented with swelling over the root of the nose since birth. Mucoid material was aspirated. Microscopic examination reveals a filamentous structured colony and crystal against the granular proteinaceous background. Features suggest benign cystic lesion and secondary actinomycosis infection, negative with an acid-fast bacilli stain consistent with Actinomyces species. As stated in most of the literature, mainly males are affected by this condition. Very little information is available on the use of fine-needle aspiration cytology (FNAC) to diagnose these lesions. We are reporting a case of an actinomycotic lesion that was reliably diagnosed with FNAC. So, we emphasized here that FNAC is aninexpensive, rapid, and simple outpatient procedure that helps in the rapid diagnosis of Actinomycosis.
Secretory carcinoma of breast: No more a juvenile tumor
Authors: Mohapatro Meenakshi , Sahoo Swati Smita , Mishra Deepika , Tripathy Milan , Das Prasant Kumar , Munda Fakir Charan , Mohanty Shushruta , Balbantray Alkananda
Published: October 2023

: Secretory breast carcinoma (SBC) is one of the rare breast neoplasm with an incidence rate of < 0.15% of all breast cancers. Previously it was described as juvenile breast carcinoma. Young children and adolescent girls are most commonly affected. It is characterized by balanced translocation t (12;15), ETV6-NTRK3 gene fusion.

: A 45 -year-old female presented with palpable lump in left breast. FNAC was suggestive of mucinous carcinoma. The diagnosis of SBC was made through histopathology and Immunohistochemistry

: Recent study report suggested that the disease may also occur at a later age group in contrast to the conventional thought of onset at juvenile age group. Long-term survival is good for these cases. In radiological studies of breast imaging it mimics a benign tumour Immuno-histochemistry and cytogenetic are of the tumour are the ancillary investigations for confirmation of diagnosis.

: Although rare diagnosis of SBC can be confirmed by histopathological studies and IHC. It is slowly progressive but has a good prognosis.
Common tumor with uncommon presentation- Immunohistochemistry, Answered the bell
Authors: Mala KG , Jadhav Meena N , Jambagi Ashwini , Haravi Rekha M
Published: October 2023

Gastrointestinal stromal tumors (GISTs), though the most common mesenchymal tumors of the gastrointestinal tract, are rare accounting approximately 1% to 3% of all gastrointestinal tumors. We report a case of a female with GIST in the ileum presenting as acute abdomen. The present case highlights on surgery, histopathological examination and immunohistochemistry as a triad that helps in answering the bell for confirmed diagnosis.
Osteopetrosis presenting as Leukoerythroblastosis in 4 month old patient: A case report
Authors: Hawaldar Ranjana , Khan Shana Nikhat
Published: October 2023

Osteopetrosis, is also known as marble bone disease or the Albers Schonberg disease. It is an extremely rare inherited disease. The disease results due to defective resorption of bone by the osteoclasts. This causes bone mass to increase accompanied by decreased hematopoietic tissue, causing extramedullary hematopoiesis. The clinical and radiological assessment plays an important role in diagnosis of infantile osteopetrosis. Clinical symptoms range from asymptomatic adults to life threatening condition in infants. We report a 4-month-old female patient with infantile osteopetrosis presenting with leukoerythroblastic blood picture and hepatosplenomegaly. This case highlights the importance of hematological findings, radiographic and genetic analysis for diagnosis of osteopetrosis.
A retrospective study of cerebellopontine angle tumours: A single instituitional study
Authors: Sundaravadhanan Shashivadhanan , Faraz Ahmed B S , Porwal Neerav , Sharma Manish , Tiwari Mannu
Published: October 2023

: Cerebellopontine angle (CPA) tumors are rare intracranial neoplasms that arise in the region between the cerebellum and the pons. These tumors can be challenging to treat due to their complex anatomy and proximity to critical neurovascular structures. Surgical intervention is often necessary to achieve a favorable outcome.

The primary objectives of this retrospective study are to analyze the clinical and radiological characteristics of cerebellopontine angle tumors, identify pathological types, assess surgical resectability, and evaluate postoperative outcomes.

: The study enrolled 14 patients who underwent surgical intervention for cerebellopontine angle tumors at Armed forces medical college, Pune. A retrospective analysis was performed, considering demographic data, clinical presentations, imaging characteristics and surgical outcomes.

: Vestibular schwannoma was the predominant tumor type with majority of tumors manifesting between third to fifth decades. Clinical manifestation included SNHL, cerebellar dysfunction, headache and sensory trigeminal dysfunction. A substantial proportion (86%) presented with no useful hearing preoperatively. Surgical outcomes indicated varying degrees of success, with total resection achieved in a subset of cases. Notably, anatomical preservation of the facial nerve was accomplished in a significant proportion of patients. Postoperative assessments, using the House Brackmann system, revealed positive facial nerve function outcomes in a substantial percentage. Complications included cerebrospinal fluid leak (14%), meningitis(7%) and lower cranial nerve paresis (7%).

: In conclusion, surgical intervention plays a crucial role in the management of cerebellopontine tumors. The choice of surgical approach should be individualized based on tumor characteristics and patient factors, with the goal of achieving maximum tumor resection while minimizing complications. Further research and advancements in surgical techniques are needed to optimize outcomes for patients with cerebellopontine tumors.
A case report of transient ischemic attack with carotid artery stenosis and discussion on the need for carotid endarterectomy
Authors: Daivasikamani Premkumar , Phyo Aung San
Published: October 2023

Carotid endarterectomy is common vascular procedure for atherosclerosis of carotid artery. Usually, it is done when the artery is narrowed more than 80% but it can be done even when it is narrowed 50 % if it produces symptoms. Carotid endarterectomy (CEA) is delayed 6 to 8 weeks after acute stoke, as the stroke can be progressive. Carotid endarterectomy (CEA) is done after optimal recovery from the stroke by the patient. The recovery depends on the preoperative size of the infarct and the neurological deficit. Emergency endarterectomy can be done when there is fluctuating neurological deficits due to acute carotid artery obstruction. CEA is contraindicated when the patient’s general condition is poor due to other serious illness which shorten life expectancy. It is not done in a case of major stroke as the recovery may not satisfactory.
Giant interhemispheric arachnoid cyst – A rare case report
Authors: Balaji S. , Venkatesan S.
Published: October 2023

IHACs (interhemispheric arachnoid cysts) are a rare kind of congenital arachnoid cyst that account for5% of all occurrences. The best surgical treatment for symptomatic IHAC is still debatable, and there are no clear standards. At the time of presentation, the median age was 13 months. Macrocrania with rapidly increasing head size, seizures, infantile spasms, and developmental delay were the most common clinical manifestations.Endoscopic cyst fenestration and shunt surgery are both safe treatments for IHAC. We present an 11-month-old male infant born to non consanguineous parents who has had a steady rise in head size since 6 months of age and delayed mile stones.A magnetic resonance image of the brain revealed a massive interhemispheric arachnoid cyst, as well as corpus callosum agenesis and hypoplasia in both frontal lobes. Baby underwent endoscopic cyst fenestration and cystoperitoneal shunt.
Identidades femininas em cena: do ódio ao silenciamento
Authors: Monnerat Rosane
Published: October 2023

Este artigo objetiva analisar comportamentos e identidades femininas afegãs oprimidas pelo regime fundamentalista islâmico, em reação ao discurso de ódio, que está no cerne da violência verbal. Analisaremos não só os imaginários sociodiscursivos que dão suporte à projeção do ethos dessas mulheres, como também os efeitos patêmicos advindos desses discursos. O suporte teórico-metodológico se baseará em estudos desenvolvidos por Charaudeau (2010, 2019) na Teoria Semiolinguística de Análise do Discurso e por estudiosos que investigam os temas focalizados, como Galinari (2020, 2014), Goffman (2021), Maingueneau (2005, 2008) e Plantin (2010). O corpus da pesquisa se constitui de três textos: uma reportagem da Marie Claire e uma postagem do Instagram, que reverberam o discurso de ódio, e um grafite de Shamsia Hassani, que sugere o “discurso do silenciamento”. Pretendemos, ao escrever sobre o tema, propor o “não silenciamento” como forma de ampliar os horizontes de luta dessas mulheres, nesse embate socioideológico.
Creatividad, Diseño y Comunicación: entre las estéticas y las realidades
Authors: Aguerre Natalia , Palacios Chavarro Janneth Arley , Valladares Cyntia , Zacipa Infante Ingrid
Published: October 2023

El contexto social contemporáneo hipermediatizado y en expansión plantea cambios en las dinámicas de la comunicación y en la configuración creativa de sentidos, posibilitando una mayor interacción e inserción de prácticas colectivas e intercambios de narrativas, medios, plataformas, lenguajes, entre otros, que invitan a la observación y análisis de estos escenarios de creación, producción, diseño y expansión de la comunicación y lo comunicativo.
La Metáfora como una herramienta de pensamiento y traducción para procesos creativos en problemas de diseño
Authors: Durán Alfaro Verónica , González Arce Jorge Alberto , Mercado Peña Claudia
Published: October 2023

Más que simplemente solucionar problemas de comunicación, el diseñador gráfico debe poder resolverlos de una manera novedosa
Una dupla creativa cyborg. Las oportunidades creativas de la conversación con modelos generativos de lenguaje
Authors: Montenegro Mauricio
Published: October 2023

A finales del siglo pasado, el filósofo de los medios Friedrich Kittler proponía pensar la escritura como un tipo de "programación".
Proyecto Musas Terrenales: creación de imágenes para la investigación a través del arte
Authors: Nuñez-Alayo Evelyn Mabel , Contreras-Morales Diego
Published: October 2023

Hasta los primeros años del siglo XXI, en Perú persiste una invisibilización, total o parcial, de cierto tipo de feminidades y cuerpos femeninos, en diferentes espacios, tanto mediáticos, como artísticos.
Review on “scope and opportunities of papain as food tenderizing agent for food processing in Ethiopia”
Authors: Tilinti Birhanu Zeleke
Published: October 2023

The basic goal of food preservation is to limit microbial development during storage, which promotes a longer shelf life and lowers the risk of food poisoning. Fruits and vegetables are a crucial addition to the human diet because they include the essential vitamins, minerals, and fiber needed to sustain good health. Papaya contains the proteolytic enzyme known as papain, which is used in a variety of food processing procedures to break down proteins. The objective of this review is to carefully study the extraction methods for papain enzyme to employ grinding and ultra-sonication extraction techniques and determine the application of papain as a preservative in future studies. Because papaya fruit contains cysteine proteinases, it can be used as a significant instrument in pharmacology and medicine. Papaya seeds, fruit, and fruit all contain carpaine, an alkaloid with a bitter taste that has a potent heart-depressant effect. Food preservation primarily aims to maintain the nutritional value of food while also preserving its appearance and increasing its shelf life. Due to papaya’s widespread popularity and reputation for its high food and nutritional value, it is necessary to fortify the fruit with the best preservation enzyme. Enzymes have evolved into critical tools for numerous industries, most notably food and animal feed, biofuels, detergents, textiles, pulp, and paper.
Interaction Between Laser Irradiation Nd:YAG (at 1064 nm) and Ultramarine Blue Pigment
Authors:   University of Vigo, Andrés-Herguedas Laura
Published: October 2023

Mural paintings located outdoor are exposed to the action of different deterioration agents that cause, among other forms of deterioration, the formation of superficial crusts. Among the cleaning methods used in cultural heritage, laser ablation is approaching to be a technique capable to ensure a success removal of these crusts, avoiding risks to the historical-artistic value of the substrate. As the literature on laser cleaning of mural paintings is scarce, this study aims to advance in understanding interactions between laser radiation and the pigments of the paintings. In this work, ultramarine blue is irradiated with a nanosecond pulsed Nd:YAG laser operating at 1064 nm and four different fluences. Modifications on colour, chemical composition and micromorphology were evaluated by means of stereomicroscopy, colour spectrophotometry and scanning electron microscopy.
Optimization of the Fused Deposition Modelling Process Parameters for the Production of Biopolymeric Scaffolds
Authors: Papa Valerio ,   Niccolò Cusano University
Published: October 2023

The advent of additive manufacturing has opened a bunch of possibilities in terms of research and advantages in various fields, starting from automotive, aerospace, to biomedical sector. Focusing on the last one, this kind of technology allows to study and design medical implants, in order to overcome limits that occur during traditional manufacturing methods, like long time and multiple steps production high cost, tissue inflammation and necrosis. The present work reports the optimisation of the printing parameters for selected biopolymers, i.e. poly(lactic acid) (PLA), polymethyl methacrylate (PMMA), poly(caprolactone) (PCL), poly(etheretherketone) (PEEK), to be used for the production of scaffolds and implants for craniomaxillofacial applications, by Fused Deposition Modelling Technology (FDM).
Towards Developing Parallel Corpora for Portuguese and Portuguese Sign Languages
Authors:   Sapienza Universitá di Roma, Khani Ziba
Published: October 2023

Low-resource languages, including sign languages, are a challenge for machine translation research. Given the lack of large-scale parallel corpora, researchers must use small parallel corpora for training an automatic translation system. This article aims to address this problem by building artificial parallel corpora for Portuguese sign language in automatic translation systems. In this work, we obtained small parallel corpora of Portuguese text and Portuguese Sign Language gloss from the Metro of Porto. We used these corpora to learn grammar rules in translation between Portuguese text and Portuguese Sign language gloss. Ap- plying obtained rules to our data, we generated artificial parallel corpora for Portuguese and Portuguese sign language gloss.
Designing Virtual Reality Scenarios for Reducing Stress Among University Students
Authors: Delgado-Parada Joseba ,   University of Vigo
Published: October 2023

Stress in assessment situations is a problem among university students that could be improved through virtual reality tools. In the framework of the project Erasmus+ VRxanny, five virtual reality scenarios were proposed to be designed in order to help students cope with stress. A preliminary study (an online survey and a Design Thinking process) was carried out, aimed at finding out the preferences of university students for relaxation. The results showed that students mainly prefer natural settings in which music has a special relevance, identifying two student profiles (active and passive). These findings have been used to guide the design of the five scenarios in two stages: the first, to develop basic stress management skills in an action game and a forest environment; in the second, aimed at developing specific skills, specific scenarios to the university context are proposed. The evidence-based proposals will allow the design of more efficient virtual reality scenarios.
Progress in Fine Arts Creativity of 13 Year Olds through Contemporary Fine Art
Authors: Kozjek Varl Katja ,   University of Maribor
Published: October 2023

Through the appropriate interpretation of contemporary works of art, pupils can develop their own critical thinking, adopt an attitude towards socially critical content and develop their artistic creativity. The basic aim of the dissertation, which we describe in the abstract and throughout the article, is the progress in pupils' creativity in relation to the implementation of contemporary fine art in the art classroom. Primarily, we were interested in art teachers' attitudes towards contemporary art practises and how they are monitored. We also created a 15-week work programme and conducted a pedagogical experiment. Before and after the experiment, we administered an art test LV2 to check the progress in artistic creativity of eighth graders and compared the results in the control and experimental groups. The results show that pupils make progress in artistic creativity when they use contemporary artworks in the classroom, and at the same time develop the creative thinking and reflect on artistic solutions.
Protected Areas in War Zones – Global Analysis Towards the Nature for Peace Concept
Authors: Wiegele Elisabeth ,   Carinthia University of Applied Sciences
Published: October 2023

Around 17% of the worldwide land ecosystems are currently under conservation [1]. Protected areas have the following three functions: protection, research and education. Through the Nature for Peace concept, the plan is to assign a further function for protected areas. Protected areas have the potential to become focal points for recuperation of those affected by an armed conflict (wounded, affected, vulnerable, uprooted persons or groups). Protected areas offer the necessary environment to carry out this rehabilitation function. To disseminate the Nature for Peace concept, the intent is to build a cluster to share materials and connect stakeholders. For establishing this cluster, a worldwide needs analysis is required. With the tool of ArcGIS the armed conflicts of the last few years were linked with protected areas in order to obtain a selection of areas where the Nature for Peace concept can be applied.
Adverse Reactions Mediated by Strontium-89, Samarium-153, Rhenium-186 and Rhenium-188: A Systematic Review of Literature
Authors:   Polytechnic Institute of Porto, Pinho Cláudia , Martins Sara
Published: October 2023

One of the therapies used for the palliative treatment of pain associated with bone metastases is radiopharmaceutical therapy. Radiopharmaceuticals can cause adverse reactions, and, therefore, the aim is to systematize the results and conclusions of studies on the use of the radiopharmaceuticals 89Sr, 153Sm, 186Re and 188Re in the palliative treatment of pain associated with bone metastases. A systematic literature review was conducted according to PRISMA statement, using the databases MEDLINE and EBSCO. After the selection process, 20 articles were included. The studies showed that the 4 radiopharmaceuticals analysed presented very similar results regarding pain relief after treatment, decrease in analgesic consumption, side effects at the time of administration, hematologic toxicity and disease progression after treatment. Concluding, the use of radiopharmaceuticals for pain palliation seems to be safe and an alternative to existing treatments.
PML/ RARA Variants and their Role in Arsenic Trioxide Resistance in APL: A Scoping Review
Authors:   University of Porto, Gonçalves Patrícia
Published: October 2023

Currently, the treatment of Acute Promyelocytic Leukemia (APL) is grounded on therapeutic regimens based on arsenic trioxide (ATO). However, mutations in the PML component of the PML/RARA oncoprotein are believed to be involved in the mechanism of resistance to this agent. We performed a scoping review to understand the role of variant PML/RARA fusion proteins in the mechanism of resistance in APL. Applying the defined criteria, we selected 10 studies, in which patients presented a picture of relapse and/or resistance after the administration of ATO, having been identified at least one PML mutation. We also reported that RARA is the most frequently mutated gene, although we also found mutations in genes related to other processes involved in cell differentiation. Briefly, this is a multifactorial mechanism and PML/RARA variants are important but not an obligatory condition for ATO resistance to occur.
Water Quality Monitoring of Shallow Lakes Through Google Earth Engine
Authors: Scarpini Eloisa ,   Niccolò Cusano University
Published: October 2023

This work focuses on the monitoring of water quality parameters in Trasimeno lake, a shallow water body located in central Italy, in the period 2015- 2022. To this aim ad hoc Google Earth Engine (GEE) based routines are implemented to analyse data from Sentinel 2 multispectral images. The spatial distribution of turbidity and chlorophyll-a concentration can be derived through the spectral band ratio method: a semi-empirical approach expressed by the mathematical ratio between the reflectance of two or more spectral bands. Two normalized indices are considered: NDTI - Normalized Difference Turbidity Index and NDCI Normalized Difference Chlorophyll-a Index. The results show an increasing trend both for turbidity and Chlorophyll-a concentration over time, highlighting a light worsening in Trasimeno lake quality status.
Use of Hackathons in Engineering Curriculum: Best Practices
Authors: Brdnik Saša ,   University of Maribor
Published: October 2023

Hackathons are increasingly more integrated into the higher education system as a form of a pedagogical approach, as their benefits are becoming more recognised. This work builds on a previously presented framework for introducing hackathons in engineering curriculum with an additional presentation of related works, gathered with a preliminary literature review of two digital databases. Seven best practices are presented from the reviewed literature and from our experience with the organisation of hackathons in one master's level academic course at the University of Maribor over four academic years. The best practices we recognised are introducing additional stakeholders, a short timeline with enforced downtime, a hackathon as an exam, preparing communication channels in advance, adjusting the level to participants, offering additional prizes for the best projects, and preparing students by teaching Design thinking concepts before the event and Intellectual property protection afterwards.
Development of property prices in Poland
Authors: Drachal Krzysztof
Published: October 2023

This research is based on a simple supply-demand model constructed for Polish property market. The first aim is to analyse the average property price in Poland between 2006 and 2013. Costs of construction and average gross salary are taken as potential determinants of supply and demand. The modified version with an unemployment rate is also considered. Simple supply and demand functions are constructed in order to explain property prices dynamics by the forces of supply and demand solely. The model fails to be statistically significant. Nevertheless, the equation for property prices obtained in the first stage is statistically significant and well fitted. The probable sources of failure of the model as a whole are discussed.
Analiza ciągłości procesów innowacyjnych w polskich przedsiębiorstwach przemysłowych
Authors: Piotrowska Joanna
Published: October 2023

Niski poziom innowacyjności w Polsce każe stawiać pytania o przyczyny takiego stanu. Niniejszy artykuł jest próbą odpowiedzi na nie w oparciu o dane statystyczne, jednak w innym ujęciu, niż prezentują to publikacje GUS. Z tego względu poddano analizie ciągłość procesów innowacyjnych w polskich przedsiębiorstwach przemysłowych w latach 2006-2012. Badanie ciągłości jest istotne, gdyż obecnie często właśnie ciągłe udoskonalanie produktu lub wypuszczanie na rynek nowych, pozwalają przedsiębiorstwu utrzymać się na rynku i budować przewagę konkurencyjną. Zaprezentowane w artykule wyniki badań pozwalają na nowe spojrzenie na zagadnienie innowacyjności przedsiębiorstw w Polsce.
Analiza czynników zewnętrznych wpływających na gospodarkę regionu przygranicznego Ukrainy w kontekście współpracy z Unią Europejską
Authors: Sosnowska Aleksandra
Published: October 2023

Nie jest tajemnicą, że po 22 latach niepodległości Ukrainy wciąż istnieje wiele scentralizowanych dysproporcji regionalnych. Obecnie powstały różne inicjatywy europejskie, które współpracują z regionami, zwłaszcza przygranicznymi pomagającym im w rozwoju. Wartykule analizujemy działania projektów i instrumentów Unii Europejskiej, które wpływają bezpośrednio na gospodarkę regionu przygranicznego Ukrainy. Analiza obejmuje w szczególności elementy polityki sąsiedztwa, działalność euroregionów.
Prehistoric and Early Medieval Fortified Settlements and High Medieval Castles on the Bohemian-Bavarian Borderland: Means of War, Power, or Symbols of Strength?/
Authors: Hložek Josef , Menšík Petr , Ławrynowicz Olgierd
Published: October 2023

The paper discusses the phenomenon of the persistence of the military, political, and social function of the present-day Bohemian-Bavarian borderland, shaped by the mountain ranges of the Bohemian Forest and the Šumava. The authors have traced the development of settlement patterns in prehistory, the Middle Ages, and the modern period, extending their studies to cover also to recent times. The discussed area constituted a barrier that limited cultural influences from both sides, which is reflected in the discovered relics of material culture. The paper also discusses, using numerous examples, the symbolic role of strongholds and castles located on mountain peaks, which came down to demonstrating the presence of power over the surrounding territory. The Bohemian-Bavarian frontier can also be seen as a peculiar landscape of conflict, which through its morphological characteristics imposed a timeless borderland form of political, military and social organisation.
БИТВА ПРИ МОХАЧЕ 1526 г. И ЕЕ ВЛИЯНИЕ НА ГЕОПОЛИТИЧЕСКУЮ СИТУАЦИЮ В ЦЕНТРАЛЬНО-ВОСТОЧНОЙ ЕВРОПE
Authors: Andrusyak Yaroslav , Tovtyn Yana
Published: October 2023

Проблема турецкой экспансии, в контексте которой рассматривается битва при Мохаче, является с исследовательской точки зрения весьма актуальной. События первой трети XVI в. кардинально изменили историческое развитие Центрально-Восточной Европы, что напрямую связано с результатами битвы при Мохаче (29 августа 1526 г.). Дата сражения стала хронологической границей в истории не только Венгерского, Чешского королевств и территорий, входивших в их состав (например, современные Словакия, Хорватия и других). Неудачная внутренняя политика представителей чешско-венгерской линии династии Ягеллонов привела к потере поддержки влиятельных чешских панов и венгерских магнатов. Не удалось привлечь в борьбу против турецкой агрессии ведущих монархов Европы. Венгерские и чешские сословия недооценили уровень опасности и заботились больше о собственных политических и экономических интересах. Все это привело к „Мохачской катастрофе”, где погиб цвет венгерского дворянства. Согласно разным статистическими данным, королевское войско насчитывало 25 000–28 000 (из них 8000 иностранцев: чехи, поляки, хорваты, сербы, немцы, итальянцы, испанцы) воинов и 53–80 орудий. Численность турецкого войска составляла 55 000–65 000 воинов и 160 пушек. Поражение при Мохаче имело тяжелейшие геополитические последствия. Так, большинство венгерской мелкой и средней шляхты поддержало Яноша Запольяи, а представители высшей знати – Фердинанда І Габсбурга, избранного и на чешский трон. На карте Европы появилось зависящее от Турции Трансильванское княжество, а на другой части Венгрии возникла так называемая Королевская Венгрия. Таким образом, Турецкая империя установила гегемонию в центрально-восточном регионе Европы с дальнейшим расширением своего влияния.
Central European Infantry Handbooks in the Time of Early Modern Military Revolution
Authors: Andresová Klára
Published: October 2023

The theory of early modern military revolution, which was presented by Michael Roberts in the 1950s and was later revised by various historians, is well known and still in use even today. One of the pillars of supposed revolution was a change of infantry training and a general change of infantry tactics, which first happened in the Netherlands in the 1590s. Another modification of infantry training and tactics took place in Sweden during the reign of Gustavus Adolphus. These transformations were reflected by a specific genre of period learned literature – military handbooks for infantry. Military manuals were published not only in Western Europe but also in Central Europe, mostly in Germany. In the period of 1550–1650, approximately 125 military handbooks were printed in ca. 225 editions. Twenty-five of these books were concerned specifically with the art of infantry war. Book history is a transdisciplinary field which offers new methods of studying military history. While researching changes of the content and formal aspects of military publications, we can trace changes of period military theory. The prosopography of military theorists and book publishers helps to reveal how the new ideas were disseminated – in this case how the new approaches to infantry training and the art of war spread from Western and Northern Europe to its centre. The aim of this contribution is not only to describe period infantry handbooks, but also to characterise the transfer of revolutionary changes in infantry warfare from Netherlands and Sweden into Central Europe with the help of period military manuals – especially those intended for infantry.
4.	ФОРМИРОВАНИЕ ДВИЖЕНИЯ СОПРОТИВЛЕНИЯ В ХАРЬКОВЕ В ПЕРВЫЕ МЕСЯЦЫ ВОЙНЫ С ГИТЛЕРОВСКОЙ ГЕРМАНИЕЙ
Authors: Diakova Helena
Published: October 2023

22 июня 1941 г. гитлеровская Германия напала на Советский Союз. Через неделю – 29 июня – Совнарком СССР и ЦК ВКП(б) издали директиву парторганизациям прифронтовой линии, где одной из задач определялась организация партизанских отрядов и диверсионных групп для борьбы с частями вермахта. Для этого создавались специальные оперативные группы. Уже в начале июля такая опергруппа начала работать в Харькове. Она состояла из партийных, комсомольских, советских активистов областного, городского, районного уровня. Кроме вышеуказанных лиц, в нее вошли и сотрудники Наркомата внутренних дел (далее:НКВД). Созданием партизанских отрядов на местах занимались оперуполномоченные НКВД, а формированием подпольных организаций – соответственно партийные и комсомольские работники. Кроме партизанских отрядов и подпольных организаций, создавались диверсионные группы, направлялись агенты, связисты, хозяева явочных квартир. Их подбором также занимались представители НКВД. Для работы во вражеском тылу в основном оставляли руководителей партийных, комсомольских, советских органов, начальствующих лиц некоторых предприятий, учреждений, колхозов, а также сотрудников НКВД, медицинских работников. Разведчиками оставляли людей, которые сотрудничали с НКВД в довоенное время. Они должны были передавать в советский тыл донесения о политическом и экономическом положении в Харькове и области, отношении местного населения к оккупантам, их союзникам, коллаборационистам. Для осуществления борьбы с оккупантами для «народных мстителей» создавались специальные базы с боеприпасами, продуктами питания, лекарствами, другими необходимыми вещами.
Trust and Compliance with Covid-19 Measures among Nigerian Households
Authors: Oladapo Oyewole Adekunle , Atela Martin , Bakibinga Pauline , Agbalajobi Damilola Taiye
Published: October 2023

This paper probes the relationship between sources of Covid-19 information and adherence to preventive measures in Nigeria, a context characterised by fake news, hate speech, and other forms of disinformation. While this relationship in Nigeria is relatively well studied, little discrete analytical attention has been given to the actor and platform components of information sources. Yet, it is important to consider the platforms people use when seeking Covid-19 information, the actors they trust to provide reliable information, and their compliance with preventive measures. This study used data from a 1,000-household telephone survey conducted in Lagos, Nigeria to understand the relationship between information platforms and actors and adherence to Covid-19 preventive measures.
WhatsApp e violência urbana nos telejornais
Authors: Grupillo Aline , Serra Joaquim Paulo
Published: October 2023

Neste artigo, nosso objetivo é  compreender as vantagens e os desafios da utilização do WhatsApp na produção telejornalística, especialmente na cobertura da violência urbana, com o propósito de discutir em que medida o fluxo de imagens que permeia o app afeta as rotinas profissionais. O WhatsApp tornou-se um dos aplicativos mais populares do mundo para o envio e recebimento de texto, som e imagem e os telejornais também exploram a sua instantaneidade a fim de conseguir flagrantes de violência, especialmente de regiões de conflito armado, hostis à presença de repórteres. Neste estudo, realizamos 13 entrevistas em profundidade com jornalistas de quatro emissoras de TV brasileiras. Essa metodologia foi complementada com a observação dos noticiários pelo período de seis meses. No geral, os jornalistas valorizam os flagrantes enviados pelo WhatsApp, pois a ferramenta se tornou fundamental para o preenchimento dos noticiários, permitindo acessar imagens de eventos de violência de determinados territórios conflagrados hostis à cobertura da imprensa tradicional, sem falar do potencial dos flagrantes para atrair a audiência. Mas, o fluxo intenso e multidirecional de flagrantes exige mais trabalho dos profissionais nos processos de apuração, o desenvolvimento de novas rotinas laborais e o dilema entre exibir ou não conteúdos não totalmente verificados.
Czas na nowe horyzonty. Ochotnicze straże pożarne a ochrona ludności
Authors: Leśniakiewicz Wiesław B.
Published: October 2023

Voluntary Fire Brigades are realizing tasks in cooperation with State Fire Services. However voluntary fire brigades are fulfilling also other goals related with civil protection. New sources of danger are causing that voluntary fire brigades needs a new law.
Ratownictwo medyczne w systemie bezpieczeństwa wewnętrznego państwa
Authors: Paplicki Mateusz , Godziński Jan
Published: October 2023

The Constitution of the Republic of Poland obliges public administration bodies to ensure the security of citizens. The authorities fulfill this constitutional obligation by establishing and maintaining appropriate emergency services. In Poland the State Medical Rescue System was creatied to provide medical assistance to people in a state of sudden health risk. Medical rescue is crucial for the sense of security of citizens because it provides help in the case of individual events related to a threat to life and health and also in situations of mass events. State authorities have created this system and are absolutely interested in its operation and effective operation. The current system of the State Medical Rescue is not a perfect institution but it requires change according to the opinion of people participating in its operation and using its services. Problems in the functioning of the State Medical Rescue Service result from, among others, limited access to primary and specialist health care and the lack of an effective mechanism capable of limiting the provision of services in hospital emergency departments to people who did not require it.
PREDICTING AND VERIFYING BUTTERFLY RICHNESS ON ISLANDS USING THE SPECIES AREA RELATIONSHIP: OTHONI (IONIAN ISLANDS) AS A CASE STUDY
Authors: DAPPORTO LEONARDO , SALVATI VANIA
Published: October 2023

We used the Species Area Relationship (SAR) (modelled with the power function) to predict the butterfly richness of Othoni, the westernmost Ionian island, (Greece), by comparing two datasets: one only based on literature data, and the other including new records. Although the SAR based on literature data indicated that butterfly richness for this island was already well sampled (nine species recorded against 7.3 predicted by the model), during a four-day fieldwork in August 2023 we spotted 11 previously unrecorded butterfly species. We discussed that the evaluation of the SAR was largely affected by under sampling of small islands while faunal inventories of large islands appeared almost complete. This was also reflected by a very high slope (z ≈ 0.5) and an intercept (c ≈ 2) which appears quite low for Mediterranean butterflies. A SAR model only including large islands and those showing richness above the 95% confidence interval revealed more trustworthy c and z values (0.3 and 8, respectively). We conclude that evaluating SAR parameters using literature data which did not originate from specifically planned research in archipelagos comprising small islands could return unreliable predictions. Moreover, we documented that the current faunal list of Othoni island can be considered sufficiently accurate to reliably include this island in wider biogeographical analyses. Key Words: Butterflies, Ionian islands, Othoni, Richness, Species area relationship.