bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of protein-carbohydrate composition of okara, chickpea flour and whey protein in the technology of minced meat cutlets
Authors: Absalimova Mamura , Tayeva Aigul , Baybolova Lyazzat , Glotova Irina , Galochkina Nadezhda , Shakhov Sergey
Published: October 2023

Kazakhstan's market for producing minced meat semi-finished products is not sufficiently developed. At the same time, the demand for products of the “economy” segment is growing. Providing balanced recipes for semi-finished meat products, with a rational combination of raw materials of animal and vegetable origin, is a significant problem. Chopped meat cutlets with high nutritional and low energy value have been developed, which are not inferior in functional and technological properties and sensory characteristics to traditional products. Pork and wheat bread were excluded from the recipes, with a replacement for lamb or broiler chicken meat in combination with a protein-carbohydrate composition (PCC) of the composition: soy minced okara – chickpea flour – whey protein concentrate (WPC 80) in a ratio of 9:5:10, at 1:3 hydration. The rational share of the introduction of PCC into the recipe of cutlets was 25% for minced beef – the meat of broiler chickens and 20% for minced beef – lamb. The studied samples of PCC, control minced meat with pork and bread, and two modified minced meat recipes for cutlets have similar values of the mass ratio of water fractions at three stages of dehydration during heat treatment. PCC particles are evenly distributed between the muscle fibers in minced meat. It has been shown that the developed PCC can serve as a substitute for minced meat not only in terms of the balance of the amino acid composition of the total protein but also in terms of the percentage of moisture with different forms of communication with the product, influencing the microstructure and consistency of raw semi-finished products of the combined composition, the consistency and juiciness of fried cutlets. According to the developed recipes, the mass fraction of protein in cutlets increased from 13.8 to 19.1-19.8%; fat decreased from 12.6 to 9.5-9.7%.
Monitoring the spread of leptospirosis agent as one of the reasons of low-quality milk
Authors: Zaritskyi Ruslan , Zhuk Yurii , Kovpak Vitalii , Derkach Serhii , Masalovych Yurii , Mazur Valerii , Cheverda Ivan , Svyrydenko Nataliіa , Drachuk Ihor , Zhurenko Vitalii
Published: October 2023

On the global scale of the zoonoses problem, leptospirosis is among the five diseases that pose the greatest threat to humankind today. Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira species. In general, leptospirosis has been registered in more than 150 species of mammals. There are about 300 serovars of Leptospira spp. Serovar Hardjo is one of the most common causes of leptospirosis among cattle globally. In cows, the infection can be completely asymptomatic or cause abortions, stillbirths, infertility, and mastitis. The study's relevance is determined by the negative impact on the economy – productivity loss, and high cost of medical-preventive activities. Leptospirosis also affects humans. In this regard, the present study aimed to determine the prevalence of antibodies to Leptospira interrogans serovar Hardjo in tank milk samples from cows selected from farms in different regions of Ukraine. The method of indirect enzyme-multiplied immunoassay was used for this problem to be investigated. We have investigated 114 tank samples from 66 Ukrainian farms, 63.2% positive, and 36.8% negative. It was established that antibodies to the causative agent of leptospirosis were recorded in different regions of Ukraine. It has been established that the largest number of positive samples was from Kyiv and Cherkasy regions. Our study results complement the study results of other authors and indicate the circulation of this causative agent among the cows in Ukraine, as well as being of practical value for diagnosing and controlling leptospirosis among the cattle.
Effect of Physiotherapy on Joint Health Status and Functional Independence of a 37-years Old Person with Hemophilia Suffering from Chronic Kidney Disease
Authors: . Manisha , Kumar Sandeep , Sambyal Smati
Published: October 2023

BACKGROUND- The common finding in hemophilia and the characteristic of a severe form is hemarthrosis, the recurrent intra-articular bleeding which further leads to synovitis and causes hemophilic arthropathy. The most common joints for bleeding are the knee, elbow, ankle, and wrist. Young adults with hemophilia are also more likely to develop age-related comorbidities, which adds to the clinical health issues already present.
CASE DESCRIPTION- A 37 years old, male subject with severe hemophilia A (factor assay<1%), high titre inhibitor and a medical diagnosis of bilateral hemophilic arthropathy in elbows, knees and ankles was included in the study. He was also diagnosed with stage-5 chronic kidney disease and had been on hemodialysis 2 times a week from the last two years prior to the study.
The joint health status using HJHS, functional independence using FISH and BI Scoring of Activities of Daily Living and pain using VAS was assessed before and after the treatment. The physiotherapy interventions were administered for 4 months, with 4 sessions a week. The Pre and post treatment scores of HJHS, FISH, BI and VAS were 49 vs 43, 9 vs 16, 5 vs 14 and 8 vs 4 respectively.
CONCLUSION- The findings of this particular case of a severe hemophiliac person who was inhibitor positive with hemophilic arthropathy of multiple joints and CKD showed that physiotherapy played a significant role in improving joint health status, functional independence and reducing pain.

Key words: Chronic kidney disease, Hemarthrosis, Hemophilia, Hemophilic arthropathy, Physiotherapy.
Prevalence of Work-Related Musculoskeletal Disorders in E-Commerce Delivery Boys from Pune (Maharashtra)
Authors: Shinde Rutuja , Jeswani Kiran
Published: October 2023

Introduction: In India E-commerce industry has been rapidly growing since last 2 decades. With the rise of E-commerce business and the demand for doorstep delivery of purchased products, the delivery workers or delivery boys have become backbone of E-commerce industry.
Due to harsh working conditions, they face increased risk for work related musculoskeletal disorders.
Method: In this study a total of 362 delivery boys of age group 20-30 years were tested for musculoskeletal disorders. They were evaluated using Standardised General questionnaire of the Nordic musculoskeletal pain questionnaire.
Result: In this study it was found that majority of delivery boys complained of low back pain which was about 69.06%. About 59.36% and 33.15% complained of shoulder and upper back pain. This was followed by neck pain with 32.04%.
Other parts of the body were also found to be affected, they are Wrist/Hand (27.07%), Knees (25.97%), Elbows (20.44%), Hips/Thighs (11.88%) and Ankles (10.22%).
Conclusion: This study revealed that E-commerce delivery boys most oftenly suffered from musculoskeletal problems and pain. Results suggest that more than half of them suffered from low back and shoulder pain. Other regional pain was less common.

Key words: E-commerce delivery boys, Nordic musculoskeletal pain questionnaire, low back pain.
Effectiveness of Computer Assisted Teaching Program on Social and Emotional Adjustment Among Adolescents
Authors: S Asha. , R Amitha. , V. S Rajitha.
Published: October 2023

The process by which all living things maintain a balance between their own needs and those of their environment is described as adjustment in the behavioural domain. This quasi-experimental study was conducted to evaluate the effectiveness of computer assisted teaching program on level of social and emotional adjustment among adolescents in selected PU colleges at Mysuru, Karnataka. A quantitative evaluative approach was adopted, purposive sampling technique and non-randomized control group research design were used for this study. There were two research setting one for Experimental group that is from BGS Pre university college, Mysore and another for Control group from Cauvery Pre university college, Mysore. The data was collected by using social adjustment rating scale. Items are based on 4 domains, Reasoning & Decision making, social introversion, social sensitivity, social amenability and Emotional adjustment rating scale. Items are based on 4 domains, Self-emotional awareness, Emotional management, Managing emotions in others, Emotional intelligence. The results of this study revealed that there is significance difference between the mean pre-test and mean post-test level of social and emotional adjustment, it was found to be significant at 0.05 level of significance t=21.01 and t=21.06 respectively. The compared overall post-test mean of social and emotional adjustment in experimental group was found to be greater than the control group and obtained t value was (17.51) and (18.93) is *p<0.05. The correlation coefficient shows positive correlation between the variables in experimental and control group the value was r=+6688 and r=+0.6390 *p<0.05. there was a significant association with age, gender, number of siblings, and previous exposure to any social and emotional adjustment program, in both experimental and control group. It shows that computer assisted teaching program is effective in improving social and emotional adjustment among adolescents.

Key words: computer assisted teaching program, social and emotional adjustment, adolescents.
An Overview of Eco-Friendly Centers in Savannahs: A Case of Bauchi Metropolis Fitness Centers, Bauchi State
Authors: Abdulqadir M. A. , Babayo A.M. , Bashir U. M.
Published: October 2023

Eco-friendly buildings and construction techniques have taken center stage as a trend that is here to stay. From sustainable home buildings to billion-dollar commercial developments, eco-friendly buildings are becoming a norm; they require fewer natural resources and produce fewer greenhouse emissions and waste. The study is aimed at highlighting on different criteria to be adopted in the provision of a well-designed fitness center capable of promoting safe and standard environment for fitness activity. A qualitative research methodology was used for the study to allow for research triangulation and wide range of data collection. The instruments of data collection used for the study include interviews, visual surveys and observation at the respective case studies selected for the study. The research found out that there is no application of features of eco-friendly building in all the selected cases studied, which resulted in non-marketability of the centers. It was also found that there is no any special or dedicated facility which adequately meets the design requirements of the fitness center in any of the selected case studies. Therefore, the study recommended feasible features to be incorporated in the design and construction of sustainable fitness centers.
Barriers to innovation for SMEs in Republic of Moldova
Authors: Novac Alexandra
Published: October 2023

SMEs play an important role in any country’s economy by contributing to job creation, innovation and value-added generation. However, despite the recognition of the important contribution of SMEs to the economy, there are a number of major barriers to innovation that prevent SMEs from developing. This paper aims to identify some important innovation barriers perceived by domestic SME entrepreneurs, as well as their perception of the changing trends in this field in recent years. The research is based on a mixed approach, using both primary and secondary data: statistical analysis and international rankings; the results of surveys and interviews with entrepreneurs from the small and medium-sized business sector, carried out and implemented over the last 8 years, with the participation of the authors; critical analysis and generalization of specialty literature, analytical materials; comparison; synthesis. The research results reveal that the innovation activity of SMEs remains rather modest, entrepreneurs facing a mix of internal and external problems. At the same time, entrepreneurs have not noticed essential changes in the last decade in terms of innovation development and implementation.
Formulation of Microsponge of Thyme for Acne Treatment
Authors: G. Maskare Rina , D. Thakre Shital , S. Jaiswal Akash , S. Chawade Darshan , S. Vishwakarma Shirali , N. Bahekar Triveni
Published: October 2023

The main goal of the present work was to improve the release of drugs i.e. Thyme for the prolonged action it is made possible for us by studying more about the novel formulation i.e. Microsponge. Microsponge is porous in nature and therefore it can release drugs for a longer time. For the preparation of the Microsponge, we use the quasi-emulsion method. White-colored porous Microsponge of thyme with ethylcellulose was obtained. Microsponge polymeric delivery systems are composed of a porous microsphere of an inert polymer that can entrap active ingredients and control their delivery rate, therefore we prepared Microsponge. Drug content, entrapment efficacy, % and yield ch 95.20±0.02, 93.15±0.02, 77.32±0.02 were determined in the Prepared Microsponge. The scanning electron microscopy showed that they were spherical in shape and contain pores. Thyme Microsponge was encapsulated into a gel for release study. It was found that 06 hours of in vitro drug release study of Microsponge was best studied by the Franz diffusion cell method. For identification of anti-acne activity of thyme oil, thyme Microsponge and thyme Microsponge gel was performed by cup plate method, from which we a get maximum zone of inhibition of thyme Microsponge gel. We have prepared, thyme Microsponge gel in various 8 batches out of which the batch shows this better potential for the of the delivery system as compared to others. From the recent work, it was assured that the thyme Microsponge gel can be considered a reliable delivery system for the treatment of acne. In future thyme Microsponge gel should be the best formulation for antiacne treatment.
The Immunological Response of Salmonella typhi Protein Subunits (Outer Membrane Protein 36 kDa, Fimbriae 36 kDa, and Flagellin) as a Candidate for Oral Typhoid Vaccine
Authors: Widyastuti Helmy , Santoso Sanarto , Winarsih Sri , Poeranto Sri
Published: October 2023

Salmonella typhi infection leads to typhoid fever on a global scale, particularly in developing countries. The currently available vaccine has its drawbacks that sporadically render a concern. Thereby, a new proffered vaccine needs to be proposed, such as a vaccine from bacteria’s protein subunits. Vaccine subunits contain only the antigenic portion of the pathogen needed to elicit a protective immune response. This research aims to assess the immunogenic potential of the protein subunit of Salmonella typhi antigen in enhancing cellular and mucosal immune responses, so it can be applied as a candidate for the typhoid fever vaccine. The Salmonella typhi protein subunits used in this research are outer membrane protein (OMP), fimbriae, and flagellin. The efficacy of the vaccine was confirmed by its production of CD4+ and CD8+ T Cells for cellular immunity response, and its production of SIgA concentration for humoral immunity response. CD4+ and CD8+ T cell examination was performed by flow cytometry analysis, while SIgA confirmation was checked by ELISA method. The result shows that, based on its immunity responses, compared with OMP, fimbriae, and flagellin have more potential to be used as a vaccine candidate against typhoid fever.
VAR2CSA protein for malaria vaccine or anticancer drug delivery? A review of preclinical and clinical research
Authors: Aditya Hakim Thalib , Retno Arimdayu Annissa , Fauziah Ma’ruf Ilma , Mayasari Wulan , Lina Wiraswati Hesti
Published: October 2023

Variant surface antigen 2- chondroitin sulfate A (VAR2CSA) is a protein belonging to the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family. Since the discovery of the protein, various studies have been carried out to utilize VAR2CSA in the clinical field. The typical application is the development of malaria vaccines and anticancer drug carriers based on VAR2CSA. Will anticancer drugs (with VAR2CSA vehicle) work effectively in patients who have already received the VAR2CSA-based malaria vaccine? Given that theoretically, the presence of antibodies triggered by the VAR2CSA vaccine might be against anticancer drugs delivered by VAR2CSA. Therefore, a review regarding the development of research on VAR2CSA, especially as a vaccine or anticancer drug vehicle, is needed. This paper provides an overview of current knowledge about VAR2CSA including its structure and function, biochemical aspects, research approaches both in vitro, ex vivo and in vivo, and the development of potential studies of VAR2CSA in the field of medicine. The literature search was carried out systematically from the PubMed database with the keywords “VAR2CSA”, “VAR2CSA” AND “vaccine”, "VAR2CSA" AND "drug delivery", "VAR2CSA" AND "cancer", "VAR2CSA" AND "placental malaria", "VAR2CSA" AND "review". A Study of VAR2CSA shows promising results, especially in the development of VAR2CSA as the main candidate for the placental malaria vaccine and anticancer drug carrier. Current findings reveal that both studies will carry out clinical trials soon. However, limitations of the study should be considered in future clinical applications for more effective cancer treatment, such as the administration of anticancer drugs by VAR2CSA vehicles on patients who have already received VAR2CSA-based antimalarial vaccines. Furthermore, an example of promising future research is leveraging other domains of VAR2CSA that have not been explored yet.
Кыргызстандагы диний топтор жана жамааттар
Authors: Мурзараимов Бакыт
Published: October 2023

IX-X кылымдардан баштап ислам динин кабыл ала баштаган кыргыздар совет дооруна чейин өздөрүнүн диний ишенимдерин, каада-салттарын сактап келишкен. Бирок совет бийлиги учурунда диний мааниде олуттуу көйгөйлөргө жана чектөөлөргө дуушар болушкан. 1991-жылы Кыргызстандын эгемендүүлүккө ээ болушу менен коомдук турмуштун көптөгөн тармактарында өзгөрүүлөр жана өнүгүүлөр боло баштады. Айрыкча мамлекеттин дин жана ишеним эркиндигин таануусу, диний жашоодо маанилүү өзгөрүүлөрдү алып келди. Бул учурда диний сезимдердин жанданышы жана адамдардын ортосунда Исламга карай бурулуштар боло баштады. Ошол учурларда өлкөбүздө бир нече диний багыттагы топтордун да таасири күч алды. Бул топтор убакыттын өтүшү менен өлкөдө уюшулуп, элдин диний түшүнүгүнө жана жашоосуна таасирдүү болууга аракет кылышты. Мамлекет алардын айрымдарын мыйзамдуу, айрымдарын мыйзамсыз деп аныктады. Бул макалада кыргыздардын кээ бир эски ишенимдери болгон бакшылык, тенирчилик, эгемендүүлүк алгандан кийин өлкөдө активдүү болгон таблиг жамааты, салафилик жана исмаилик сыяктуу топтор жана кээ бир христиан багытындагы топтор, ошондой эле, батыштан келген миссионердик топтор кыскача каралган.
Digital Game Addiction Tendency and Social Competence in Preschool Children: The Mediating Role of Self-Regulation
Authors: BAĞATARHAN Tuba
Published: October 2023

The aim of this study is to investigate the relationship between digital game addiction tendency and social competence in preschool children and the mediating role of self-regulation skills in this relationship. The sample included 310 preschool children aged 4-6 years (150 girls and 160 boys) studying in three kindergartens in the city center of Aydın. Digital Game Addiction Tendency Scale, Self-Regulation Skills Scale for 4–6-Year-Old Children (Mother Form), Social Competence and Behavior Evaluation-30 Scale - Social Competence Subscale, and Personal Information Form were used to collect the data. Descriptive statistics, Pearson product-moment correlation, and structural equation modeling were used to analyze the data. The results of the Pearson product-moment correlation analysis showed that digital game addiction tendency was negatively correlated with self-regulation skills and social competence in preschool children. Moreover, the results indicated that there was a positive association between self-regulation skills and social competence in preschool children. The results of the structural equation model analysis revealed that digital game addiction tendency was directly related to self-regulation skills and indirectly related to social competence. Self-regulation skills have a full mediating role in the relationship between digital game addiction tendency and social competence. The research revealed the negative effects of digital game addiction on self-regulation skills which in turn affects social competence in preschool children. The results suggest that the effects of digital game addiction and self-regulation skills should be considered when assessing the social skills of preschool children.
DIABETES MELLITUS MANAGEMENT
Authors: Hakim Alfi , Ismunandar Helmi , Wahyuni Ari , Sangging Putu Ristyaning Ayu
Published: October 2023

Diabetes melitus adalah suatu penyakit yang masuk kedalam kelompok penyakit metabolik dengan tanda hiperglikemia sebagai akibat dari adanya defek sekresi insulin, kerja insulin ataupun keduanya. Indonesia menempati urutan ke-7 dalam hal prevalensi diabetes tertinggi di dunia. WHO melaporkan apabila jumlah pasien diabetes melitus di Indonesia meningkat dari 8,4 juta pada tahun 2000 menjadi 21,3 juta pada tahun 2030. Pada tahun 2022 sendiri, International Diabetes Federation mencatat ada 537 juta penderita DM di seluruh dunia. Patofisiologi dari diabetes melitus sendiri adalah sebuah proses kompleks dan melibatkan banyak faktor. Umumnya, diabetes dikelompokkan menjadi beberapa jenis, yaitu diabetes melitus tipe 1, diabetes melitus tipe 2, diabetes gestasional, dan diabetes spesifik lain. Apabila tidak dikelola dengan baik, Diabetes melitus akan menyebabkan berbagai macam komplikasi. Yang paling umum terjadi ialah retinopati diabetic. Retinopati diabetic adalah penyebab kebutaan paling utama. Pasien diabetes melitus juga dapat disertai dengan hipertensi. Hipertensi dan Diabetes melitus adalah dua penyakit yang mempunyai kaitan yang sangat erat. Insulin adalah satu-satunya obat yang digunakan untuk pasien Diabetes Melitus Tipe 1, namun selain itu juga harus dibarengi dengan pengaturan makan, olahraga,dan edukasi, yang didukung oleh pemantauan mandiri, sedangkan Diabetes Melitus Tipe 2 diberikan tatalaksana dengan obat metformin sebagai lini pertama dan non farmakologi untuk menurunkan glukosa darah.
HUBUNGAN LAMA PENGGUNAAN VENTILATOR MEKANIK DENGAN MORTALITAS DI INTENSIVE CARE UNIT (ICU) RSUD Dr. H. ABDUL MOELOEK
Authors: Noviyanti Dwi Wulan , Wahyuni Ari , Ramdini Dwi Aulia , Rahmayani Fidha
Published: October 2023

Latar Belakang: Ventilator mekanik merupakan alat bantu napas yang digunakan pada pasien gagal napas. Penggunaan ventilator mekanik lebih dari 48 jam dapat menimbulkan komplikasi yang dapat meningkatkan mortalitas pada pasien. Mengetahui hubungan antara lama penggunaan ventilator mekanik dengan mortalitas di ICU dapat membantu dalam mengurangi faktor penyebab mortalitas pasien di ICU. Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional. Subjek merupakan 97 data rekam medik dengan teknik simple random sampling yang diproses menggunakan aplikasi SPSS. Penelitian ini menggunakan data sekunder berupa data rekam medik pasien ICU dengan penggunaan ventilator mekanik yang memenuhi kriteria inklusi dan eksklusi sampel. Analisis yang digunakan adalah chi-square. Hasil: Hasil penelitian menunjukkan mayoritas subjek berusia >65 tahun (37,1%),berjenis kelamin laki-laki (60,8%), pasien non bedah (56,7%), diagnosis utama terbanyak yaitu ICH (17,5%), CKD (10,3%), CHF (6,2%), dan peritonitis (6,2%), lama penggunaan ventilator ≥48 jam (61,9%), dan pasien meninggal (83,5%). Tidak terdapat hubungan antara lama penggunaan ventilator mekanik dengan mortalitas (p = 0,734). Simpulan: Lama penggunaan ventilator mekanik tidak memiliki hubungan  dengan motalitas di ICU RSUD Dr. H. Abdul Moeloek.
Perbedaan Pengetahuan Sebelum dan Sesudah Pemberian Booklet Pencegahan Hipertensi Pada Petani di Desa Karang Anyar Kabupaten Lampung Selatan Tahun 2021
Authors: Fawwaz Muhammad Gusti , Saftarina Fitria , Kurniawati Evi , Rengganis Wardani Dyah Wulan Sumekar
Published: October 2023

Hipertensi atau tekanan darah tinggi merupakan kondisi medis yang serius dan secara signifikan meningkatkan risiko jantung, otak, ginjal, dan penyakit lainnya. hipertensi lebih besar pada negara-negara berpenghasilan rendah dan menengah dibandingkan di negara-negara berpenghasilan tinggi. Pencegahan hipertensi dapat dilakukan dengan berbagai upaya, salah satu upaya meningkatkan pengetahuan masyarakat dibutuhkan adanya upaya pendidikan kesehatan. Penelitian ini dilakukan untuk mengetahui perbedaan pengetahuan sebelum dan sesudah pemberian booklet pencegahan hipertensi pada petani di Desa Karang Anyar Kabupaten Lampung Selatan tahun 2021. Metode yang digunakan dalam penelitian ini adalah analitik eksperimental desain eksperimen semu (Quasi Eksperimen). Pendekatan yang digunakan dalam penelitian ini yaitu One Group Pretest-Postest, sebanyak 334 petani yang memenuhi kriteria inklusi. Kemudian data dianalisis menggunakan uji paired t-test.Hasil penelitian didapatkan hasil rata-rata nilai pengetahuan petani sebelum diberikan media booklet adalah kurang dengan mean 5.38. Sedangkan nilai rata-rata pengetahuan petani sesudah diberikan media booklet adalah cukup dengan mean 6.81. Hasil uji statistik didapatkan nilai P value sebesar 0.000. yang memiliki arti terdapat perbedaan yang signifikan rata-rata nilai pengetahuan petani sebelum dan sesudah diberikan media booklet. Kesimpulan dari penelitian ini adalah terdapat perbedaan signifikan rata-rata nilai pengetahuan petani sebelum dan sesudah diberikan media booklet pencegahan hipertensi di Desa Karang Anyar dengan P value 0.000.
Penatalaksanaan Holistik Pasien Wanita Usia 18 Tahun dengan Asma Bronkial Melalui Pendekatan Dokter Keluarga di Wilayah Puskesmas Satelit
Authors: Nur Pratiwi Jihan , Nusadewiarti Azelia
Published: October 2023

Asma merupakan peradangan kronik saluran napas yang menyebabkan penyempitan saluran napas. Prevalensi penyakit asma di Indonesia menempati urutan tertinggi untuk kategori penyakit tidak menular. Asma merupakan penyakit yang perlu dikontrol untuk mencegah eksaserbasi dan meningkatkan kualitas hidup pasien. Baik pasien maupun keluarga diharapkan memiliki pengetahuan dan motivasi untuk melakukan modifikasi gaya hidup agar tujuan pengobatan dapat tercapai, sehingga diperlukan tatalaksana melalui pendekatan keluarga. Data primer diperoleh dari kunjungan rumah untuk melengkapi data keluarga, data psikososial, dan lingkungan. Data sekunder diperoleh dari rekam medis. Penilaian dilakukan berdasarkan diagnosis holistik dari awal, proses, dan akhir studi secara kuantitatif dan kualitatif. Pasien Ny. PF usia 18 tahun, memiliki keluhan utama sesak napas sejak 1 hari yang lalu. Sesak disertai bunyi ngik dan batuk,  memberat terutama saat malam dan menjelang pagi,  cuaca dingin, dan setelah membersihkan rumah. Pasien didiagnosis sebagai asma bronkial. Pada kasus ini telah dilakukan diagnosis dan tatalaksana sesuai dengan teori dan jurnal terkini. Setelah dilakukan intervensi, didapatkan penurunan gejala klinis dan peningkatan pengetahuan pasien dan keluarganya. Diagnosis asma bronkial pada pasien ini sudah sesuai dengan teori dari beberapa panduan dan jurnal, terlihat adanya perubahan pengetahuan pada pasien dan keluarganya setelah dilakukan intervensi berdasarkan Evidence-Based Medicine yang bersifat patient-centred dan family approach.
Identifikasi ¬Methicillin-Resistant Staphylococcus aureus (MRSA) pada Pasien Dermatitis Atopik RSUD Dr. H. Abdul Moeloek Bandar Lampung
Authors: Enjelina Enjelina , Warganegara Efrida , Mutiara Utari Gita
Published: October 2023

Angka kejadian DA di Indonesia meningkat setiap tahunnya dan menempati peringkat pertama dari 10 besar penyakit kulit anak pada tahun 2010. Prevalensi DA di Lampung sendiri menempati urutan kesepuluh dalam daftar sepuluh besar penyakit provinsi Lampung pada tahun 2016 dengan jumlah 44.034 kasus. Pada lebih dari 90% kulit penderita dermatitis atopik didapatkan kolonisasi Staphylococcus aureus  sebagai akibat dari gangguan sawar kulit dan imunitas alamiah. Sejak kemunculan galur S. aureus yang resisten terhadap antibiotik metisilin tahun 1961, MRSA mulai ditemukan pada lesi pasien dermatitis atopik. MRSA telah menjadi masalah kesehatan global yang sangat berhubungan dengan infeksi yang susah disembuhkan dan morbiditas yang tinggi. Penelitian ini bertujuan untuk mengetahui ada tidaknya MRSA pada lesi pasien dermatitis atopik yang berobat ke Poli Kulit dan Kelamin RSUD Abdul Moeloek Bandar Lampung. Penelitian ini merupakan penelitian observasional dengan rancangan potong lintang. Pengumpulan sampel diperoleh berupa swab dari lesi pasien pada periode Maret hingga Mei 2019, kemudian dilakukan identifikasi bakteri MRSA di laoratorium dengan dilakukan kultur pada media agar. 57,7% penderita DA memiliki kolonisasi Staphylococcus aureus dan 20% di antaranya adalah MRSA.
Malassezia Furfur Pada Pitriasis Versikolor Dan Malassezia Folikulitis
Authors: Tarigan Hendra , Graharti Risti
Published: October 2023

Kulit merupakan salah satu organ terbesar tubuh yang menampung berbagai komunitas mikroba termasuk organisme yang tidak berbahaya tetapi juga dapat menjadi patogen potensial. Malassezia merupakan bagian dari flora normal kulit yang memiliki potensi patogen di mana dalam kondisi yang sesuai dapat  menginvasi stratum korneumdan bermanifestasi pada berbagai penyakit tkulit diantaranya pitiriasis versikolor dan malasezia folikulitis. Infeksi ringan kronis pada kulit yang disebabkan oleh jamur malassezia furfur, ditandai dengan bercak hipopigmentasi atau depigmentasi disertai skuama, dikenal sebagai Pitriasis versicolor atau PVC. Folikulitis malassezia adalah kondisi peradangan yang disebabkan oleh malassezia yang melibatkan unit lebih dalam yaitu pilo-sebasea. Pitiriaris Versikolor dan malasezia folikulitis merupakan penyakit kulit yang mendunia. Pitiriasis versikolor dan malasezia folikulitis sering terjadi di daerah tropis dan iklim yang panas serta memiliki kelembaban dan suhu yang tinggi, seperti di Indonesia. Di Indonesia diperkirakan 50% penduduknya menderita PV. Penyakit ini dapat mengenai semua golongan mulai dari anak-anak sampai orangtua. Dengan banyaknya angka kejadian PV dan malasezia folikulitis di Indonesia, maka penulis tertarik untuk membuat referat ini. Penulisan referat ini bertujuan agar penulis dan pembaca lebih dapat memahami karakterisktik kedua penyakit ini sehingga dapat mendiagnosis dan menatalaksana dengan tepat serta melakukan pencegahan sehingga dapat mengurangi angka kejadian PV dan malassezia folikulitis di Indonesia.
Pengaruh Senam Kaki Diabetik terhadap Neuropati pada Pasien Diabetes Melitus
Authors: Qurotulnguyun Lutfia , Rahmayani Fidha , Sutarto Sutarto
Published: October 2023

Prevalensi penderita diabetes melitus mengalami peningkatan setiap tahunnya. Indonesia menempati peringkat ke-7 dunia dengan jumlah penderita diabetes mencapai 10,7 juta jiwa. Diabetes dalam jangka waktu yang lama dapat menyebabkan komplikasi makrovaskular dan mikrovaskular.  Salah satu komplikasi uatama diabetes melitus adalah neuropati diabetik. Neuropati diabetik adalah komplikasi mikrovaskuler yang menyebabkan disfungsi saraf perifer yang menyerang ekstrimitas bawah terutama tungkai. Sekitar 50% penderita diabetes melitus mengalami neuropati diabetik. Jika tidak ditangani dengan baik, kondisi ini dapat menurunkan kualitas hidup pasien, meningkatkan risiko amputasi, bahkan kematian pada penderita diabetes.  Obat-obatan seringkali menjadi pilihan utama untuk terapi, namun kendala biaya dan efek samping menimbulkan minat untuk mencari alternatif pengobatan lain. Pengobatan yang dapat dilakukan adalah dengan berolahraga. Salah satu olahraga yang dianjurkan adalah senam kaki diabetik. Senam kaki diabetik merupakan olahraga ringan berfokus pada tungkai yang terdiri dari sepuluh langkah. Olahraga ini dapat dilakukan dengan  mudah, tidak membutuhkan biaya, dan tidak memakan waktu yang lama. Beberapa studi menyatakan bahwa senam kaki diabetik dapat menjadi alternatif untuk mencegah dan menghambat perburukan neuropati pada pasien diabetes melitus dengan membantu memperlancar sirkulasi darah perifer serta menguatkan otot-otot pada ekstrimitas bawah untuk mencegah luka dan deformitas  kaki.
Penatalaksanaan Holistik Dermatitis Atopik Pada An. N Usia 12 Tahun Di Puskesmas Kota Karang Melalui Pendekatan Kedokteran Keluarga
Authors: Sureda Kuntum , Fandana Refi , H. Sibuea Sahab
Published: October 2023

Dermatitis atopik, atau disebut juga eczema adalah bentuk paling umum dari dermatitis kronis. Penyakit ini umumnya identic dengan pruritus memiliki karakteristik klnis berupa kulit kering, lesi kronik, dan likenifikasi. Dermatitis atopik diyakini berhubungan dengan bentuk dari kelainan IgE lain seperti rinitis alergi, asma, dan intoleransi terhadap makanan. Penyakit ini menghasilkan tingkat morbiditas yang tinggi dan prevalensinya meningkat dalam beberapa dekade terakhir. Studi yang dilakukan adalah laporan kasus. Data diperoleh melalui anamnesis dan pemeriksaan fisik dengan melakukan kunjungan rumah. Penilaian dilakukan berdasarkan diagnosis holistik, proses, dan akhir kunjungan secara kualitatif. Berdasarkan pemeriksaan yang dilakukan, pasien adalah anak perempuan usia 12 tahun dengan dermatitis atopik. Pengetahuan pasien dan keluarga tentang penyakit sangat terbatas. Edukasi dan intervensi diberikan kepada pasien dan keluarga tentang dermatitis atopik dan faktor resiko yang dapat memicu terjadinya penyakit ini. Pada faktor internal pada kasus seperti faktor genetik, usia, dan ketidaktahuan mengenai faktor pencetus. Faktor eksternal kurangnya pengetahuan keluarga mengenai dermatitis atopik, komplikasinya dan lingkungan yang memiliki banyak alergen. Dilakukan intervensi farmakologis dan non farmakologis berupa edukasi dalam mencegah kambuhnya gejala dermatitis atopik pada pasien. Dalam evaluasi ditemukan peningkatan kepatuhan pasien untuk menghindari faktor risiko serta pengetahuan keluarga tentang perawatan pasien. Pelayanan dengan pendekatan kedokteran keluarga dalam terapi farmakologis maupun nonfarmakologis mampu menyelesaikan masalah kesehatan dan meningkatkan kualitas hidup pasien.
Faktor Risiko Kejadian Rinitis Alergi pada Anak
Authors: Nurhaliza Intan , Imanto Mukhlis
Published: October 2023

Rinitis alergi termasuk salah satu masalah kesehatan global yang mempengaruhi hampir 400 juta orang di dunia dengan prevalensi 8,38% pada anak dan 14,93% pada remaja, sedangkan di Indonesia angka kejadian rinitis alergi mencapai 38%. Rinitis alergi merupakan suatu gejala klinis yang timbul ketika membran mukosa hidung terpapar suatu alergen dan menginduksi respon inflamasi yang diperantarai oleh sistem imun. Rinitis alergi dapat dipicu oleh beberapa faktor, termasuk faktor individu dan lingkungan yang dapat menyebabkan sensitisasi ulang dan perkembangan penyakit. Faktor risiko utama rinitis alergi adalah adanya riwayat atopi pada keluarga, terutama riwayat rinitis alergi pada kedua orang tua. Adanya dermatitis atopik, asma, paparan asap kendaraan, rokok dan debu rumah, serta obesitas dapat menjadi faktor yang meningkatkan risiko kejadian rinitis alergi pada anak. Faktor risiko tersebut memiliki mekanisme masing-masing dalam meningkatkan risiko rinitis alergi dan memiliki tingkat risiko yang berbeda-beda. Faktor lain seperti jenis kelamin dan usia tidak berkontribusi dalam meningkatkan risiko rinitis alergi pada anak.
Tatalaksana Malaria Berat
Authors: Sema Gigaramadan , Mutiara Hanna , Soleha Tri Umiana
Published: October 2023

Malaria adalah penyakit yang disebabkan oleh infeksi parasit Plasmodium. Malaria berat adalah malaria yang disertai dengan komplikasi seperti malaria serebral, kejang, gagal ginjal akut, syok hemodinamik, dan lain sebagainya. Artesunat intravena adalah pengobatan lini pertama untuk malaria berat yang disebabkan semua spesies Plasmodium. Terapi RRT dini perlu dilakukan untuk menangani gagal ginjal akut, dan resusitasi cairan secara hati-hati dilakukan untuk mencegah edema paru yang letal. Delayed-onset hemolysis setelah pemberian Artesunat mengharuskan pemeriksaan hemoglobin dan pemantauan pasca pengobatan. Pengobatan ACT setelah komplikasi mereda menjadi lini pertama, dilanjutkan dengan pemberian Primaquine untuk mengatasi kasus relaps. Pemeriksaan G6PD diperlukan sebelum permberian Primaquine untuk mencegah hemolisis.
Hubungan Ketepatan Peresepan Obat Anti Hipertensi Terhadap Tekanan Darah Pasien Hipertensi
Authors: Saputra Magdalena Yosefin , Rengganis Wardani Dyah Wulan Sumekar , Oktarlina Rasmi Zakiah
Published: October 2023

Hipertensi merupakan sebuah penyakit yang ditandai dengan meningkatnya tekanan darah seseorang lebih dari ambang tekanan darah normal. Hipertensi merupakan penyebab kematian dini terbanyak ke-3 di dunia. Penyakit ini juga dijuluki sebagai silent killer karena kebanyakan penderita tidak mengalami keluhan yang spesifik, namun keluhan timbul setelah terjadi kelainan organ akibat hipertensi. Upaya pencegahan dan pengobatan hipertensi dapat dimulai dengan perubahan pola hidup seperti konsumsi buah dan sayur, konsumsi rendah garam dan lemak, rutin berolahraga, dan tidak merokok. Selanjutnya, pengobatan berupa tatalaksana farmakologi juga dibutuhkan untuk mengatur tekanan darah agar tidak melebihi batas normal. Pemberian obat anti hipertensi juga bertujuan untuk mencegah komplikasi akibat tekanan darah tinggi. Tatalaksana farmakologis menggunakan obat antihipertensi seperti diuretik, penghambat andrenergik, angiotensin converting enzyme inhibitor (ACE-inhibitor), penghambat angiotensin-II, antagonis kalsium, vasodilator langsung. Tercapainya target terapi pada pasien hipertensi berarti adanya penurunan tekanan darah hingga mencapai batas normal. Pada pasien yang mendapat peresepan obat antihipertensi secara tepat, dinilai memiliki kemungkinan 6 hingga 13 kali lipat untuk mendapatkan efek terapeutik antihipertensi yang sesuai target dibandingkan dengan pasien yang mendapat terapi obat antihipertensi tidak tepat.
25 lat odnowy wsi w Polsce – koniec misji czy zaczyn odnowy wsi 2.0?
Authors: Wilczyński Ryszard
Published: October 2023

Opolski Program Odnowy Wsi (OPOW), inspirowany wzorcami z Austrii i Niemiec, w roku 1997 wyznaczył początek upowszechnienia się odnowy wsi w Polsce. Wyniki programu i rosnące nim zainteresowanie zrodziły oczekiwanie, iż odnowa wsi i w tym kraju wyznaczy perspektywę rozwoju obszarów wiejskich. Nowatorska ówcześnie idea, przeciwstawiająca się prostej modernizacji/umiastowieniu wsi, wywierała znaczący wpływ na przemiany obszarów wiejskich. Ujęta w ramy kolejnych programów regionalnych była obiecującą metodą animacji procesów poprawy ogólnego stanu wsi, w których siłą sprawczą pozostawała społeczność wiejska, a efektem usuwanie zapóźnień, poprawa warunków życia, a jednocześnie zachowanie dziedzictwa kulturowego i umacnianie tożsamości wiejskiej wspólnoty. 25-lecie OPOW w 2022 r. stworzyło okazję do prezentacji okoliczności zaistnienia odnowy wsi w Polsce jako wiodącego podejścia bottom-up, silnego jego oddziaływania, a następnie zaskakującego regresu. Artykuł analizuje systemowe przyczyny, z powodu których odnowa wsi stała się podejściem niszowym. Wskazano na zaniechania i brak adekwatnego do zmieniającej się sytuacji (depopulacja i starzenie się społeczności wiejskich) know-how po stronie krajowej polityki rozwoju. Szczególnie brzemienny w skutki był błąd niewbudowania odnowy wsi w system rozwoju obszarów wiejskich oraz oddzielenie jej od działań ustawowo regulowanych pod nazwą rewitalizacji. Celem pracy jest wskazanie na odnowę wsi jako wciąż aktualną metodę rozwoju i szansę na wprowadzenie nowej jakości do krajowej polityki rozwoju. Stworzenie stosownej ramy prawno-instytucjonalnej mogłoby stanowić zaczyn nowego cyfrowego etapu jej oddziaływania w sposób tożsamy ze smart villages.
Odnowa wsi w Polsce – refleksje po 25 latach realizacji programu
Authors: Kamiński Ryszard
Published: October 2023

Wspominając 25 lat programu odnowy wsi w Polsce, warto pokusić się o pewne podsumowanie, przypomnieć jego inspiracje i działania podejmowane w różnych miejscach Polski. Temu właśnie celowi służyła konferencja, która w 2022 r. odbyła się w Gogolinie. Spotkali się tam ludzie w różny sposób zaangażowani w odnowę wsi w Polsce. W poniższym artykule zestawiono refleksje i wnioski autora z perspektywy uczestnika procesu odnowy wsi, trenera upowszechniającego ten program, lidera inspirującego jego działania na terenie wiejskim, w którym mieszka, i badacza starającego się uchwycić elementy zachodzącej przy tej okazji zmiany społecznej. Poza przeglądem tych perspektyw jest tu również nawiązanie do włączenia odnowy wsi do funduszy strukturalnych UE jako programu dotacyjnego finansowanego ze środków unijnych i wynikających z tego komplikacji, jak również pozytywów.
Exploring the limits of the pastoral profession
Authors: Sirris Stephen
Published: October 2023

Two discourses frame the pastoral profession in the Evangelical Lutheran Church of Norway: one is the professional, which emphasises religion, while the other is organisational and foregrounds management. This article explores interactions, between pastors and a dean, that are situated on the boundaries of these two discourses. From the theoretical perspective of institutional boundary work, I analyse a case study that highlights observational data, and in particular, meetings and performance appraisal interviews with pastors. The research question is as follows: How do interactions between pastors and deans serve as spaces for discursive boundary work by the pastoral profession? As the church aligns itself with modern work organisations, the findings show how the clergy construct themselves and their work by drawing on both discourses. This article discusses how pastoral work is perceived discursively as both a modern occupation and also a religious profession through efforts that can be described as competitive, collaborative and configurational boundary work. Interactions constitute a space where the actors work for, at and through these boundaries by negotiating their core work, relationships and theology.
Research and development of a cross-platform application for watching movies and TV series with Chat GPT AI integration
Authors: Mukhamedin A. A. , Abitova G. A.
Published: October 2023

The article presents the results of the research and development of a cross-platform application for watching movies and TV series with Chat GPT AI integration. In today's world, choosing movies and TV series is becoming increasingly difficult due to the huge amount of content available. Users are looking for tools that will help them find and enjoy interesting films and TV series. The main contribution of this article is the presentation of a developed cross-platform application that combines the ability to watch movies and TV series with ChatGPT artificial intelligence. The app provides unique features including powerful search and content filtering, personalized recommendations based on user preferences, and the ability to interact with ChatGPT for recommendations and communication. We take an in-depth look at key aspects of the app, including its functionality and user interface, and provide technical details and solutions used in development. Particular attention is paid to machine learning technologies and algorithms used to improve the quality of recommendations and enrich the user experience. This article not only introduces the entertainment aspect, but also demonstrates how combining entertainment and artificial intelligence can make the user experience in the world of streaming content more interesting and satisfying. We invite readers to review the research details and technological aspects of this innovative project.
Cumhuriyet ve Arkeoloji Teması: Van İli Örneği
Authors: POLAT Erdal
Published: October 2023

Kültürlerin kavşak noktası konumunda olan ve birçok imparatorluğa/devlete ev sahipliği yapmış olan Anadolu, bu imparatorlukların/devletlerin sosyal, siyasal, kültürel ve beşeri yaşanmışlıklarına şahit olmuştur. Söz konusu coğrafya birçok açıdan incelendiğinde bu yaşanmışlıklarda bazı dönüm noktaları olduğu görülmektedir. Cumhuriyet’in ilanı tarihimizdeki en önemli dönüm noktası olmuş ülkemizin her bir alanına sirayet etmiştir. Ülkemize dair yapılan her bir çalışma Cumhuriyet öncesi ve sonrası şeklinde bir araştırmaya tabi tutulduğunda, Cumhuriyet’in getirdiklerine dair daha doğru bir okuma yapılabilir.

Cumhuriyetin ilanıyla birçok alanda olduğu gibi arkeoloji alanında da yeni yol haritaları çizilmiştir. Yurt dışına gönderilen öğrenciler, hız kazanan kazı çalışmaları Cumhuriyet’in arkeolojiye dair bilim politikalarından olmuş, bu gelişmeler ülkemizdeki arkeoloji çalışmalarına yansımıştır. Van ili özelinde de görülen bu çalışmalarda birçok alanda kazının yapıldığı ve Van ilinin tarihi derinliğine ışık tutulduğu görülmüştür. Her ne kadar Cumhuriyet öncesinde de Van ilinde kazı çalışmaları yapılmış olsa da Cumhuriyet ile bu çalışmaların daha bilimsel bir boyut kazandığını söylemek doğru olacaktır.

Bu çalışmada Doğu Anadolu Bölgesi sınırları içerisinde kalan Van ilinde 1950 li yıllara kadar yapılmış arkeolojik çalışmalar ele alınmıştır. Bu çalışmaların Cumhuriyet’in bilim politikalarından ne kadar etkilendiği Van ili örneğiyle saptanmıştır. Böylelikle Cumhuriyet ve arkeoloji teması Van ili örneğinde somutlaştırılmıştır.
Bir İnkılabın Ardından: Kastamonu'da Şapka ve Kıyafet İnkılabı Kutlamaları (1934-1980)
Authors: YILMAZ Mehmet Serhat
Published: October 2023

Gazi Mustafa Kemal Atatürk, 23 Ağustos 1925 ile 1 Eylül 1925 tarihleri arasında Ankara’dan ayrılarak Kastamonu gezisine çıkmıştır. Bu gezinin önemi, şapka ve kıyafet inkılabına ilişkin ilk konuşmaların Kastamonu’da yapılmış olmasıdır. Bu makalede, Atatürk’ün Kastamonu seyahatinden, 1934-1980 yılları arasında Kastamonu’da yapılan “Şapka ve Kıyafet İnkılabı” kutlamaları araştırılmıştır. Araştırmada kutlamaların Kastamonu’da ne zaman başlatıldığı, nasıl yapıldığı sorusunu cevap aranmıştır. Kutlamaların değişen zaman içerisinde kutlanış biçimi, kutlama programları üzerinden değerlendirilmiştir. Araştırmada literatür üzerinden yapılmış, araştırma inceleme eserlerinden yararlanılmıştır. Çalışma verilerinin derlenmesinde dönem içinde yayımlanan Kastamonu, Doğrusöz, Karadeniz ve Yenises yerel gazeteleri kullanılmıştır.

Sonuçta, Kastamonu’da Şapka ve Kıyafet İnkılabı kutlamaları mahalli milli bir gün olarak 1934 yılında Halkevi merkezli başlatılmıştır. Kutlamalara verilen isimler zaman içerisinde değişiklik göstermiştir. Başlangıçta “Gazi Günü” ve “Atatürk Günü” olarak isimlendirilen kutlamalar daha sonra “Şapka İnkılabı” veya “Şapka Devrimi” şeklinde ifade edilmiştir. Etkinlikler Atatürk’ün vefatı, İkinci Dünya Savaşı, askeri darbe dönemlerinin ilk yılları, hava durumu gibi çeşitli sebeplere bağlı olarak dönemin şartlarına göre kapsamlı veya sade bir tören şekline yapılmıştır. Kutlama törenleri zaman zaman sıradan ve sönük geçtiği eleştirilerine de maruz kalmıştır. Şapka ve kıyafet inkılabı törenleri için Kastamonu’da bir milli gün kutlama geleneğinin oluştuğu anlaşılmaktadır. Günümüzde Kastamonu resmi kurum ve kuruluşları, sivil toplum örgütleri ve halkın geniş katımlıyla bir yerel millî gün olarak kutlama geleneği devam etmektedir.