bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer
Authors: Fennell Emily M. J. , Aponte-Collazo Lucas J. , Pathmasiri Wimal , Rushing Blake R. , Barker Natalie K. , Partridge Megan C. , Li Yuan-Yuan , White Cody A. , Greer Yoshimi E. , Herring Laura E. , Lipkowitz Stanley , Sumner Susan C. J. , Iwanowicz Edwin J. , Graves Lee M.
Published: March 2023

ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenotypic outcomes following ClpP activation, the exact mechanism by which ClpP activation leads to broad anti-cancer activity has yet to be fully elucidated. In this study, we utilized a multi-omics approach to identify the ClpP-dependent proteomic, transcriptomic, and metabolomic changes resulting from ONC201 or the TR compound TR-57 in triple-negative breast cancer cells. Applying mass spectrometry-based methods of proteomics and metabolomics, we identified ∼8,000 proteins and 588 metabolites, respectively. From proteomics data, 113 (ONC201) and 191 (TR-57) proteins significantly increased and 572 (ONC201) and 686 (TR-57) proteins significantly decreased in this study. Gene ontological (GO) analysis revealed strong similarities between proteins up- or downregulated by ONC201 or TR-57 treatment. Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). Less than 21% of these genes were affected by these compounds in ClpP null cells. GO analysis of these data demonstrated additional similarity of response to ONC201 and TR-57, including a decrease in transcripts related to the mitochondrial inner membrane and matrix, cell cycle, and nucleus, and increases in other nuclear transcripts and transcripts related to metal-ion binding. Comparison of response between both compounds demonstrated a highly similar response in all -omics datasets. Analysis of metabolites also revealed significant similarities between ONC201 and TR-57 with increases in α-ketoglutarate and 2-hydroxyglutaric acid and decreased ureidosuccinic acid, L-ascorbic acid, L-serine, and cytidine observed following ClpP activation in TNBC cells. Further analysis identified multiple pathways that were specifically impacted by ClpP activation, including ATF4 activation, heme biosynthesis, and the citrulline/urea cycle. In summary the results of our studies demonstrate that ONC201 and TR-57 induce highly similar and broad effects against multiple mitochondrial processes required for cell proliferation.
Preeclampsia history and postpartum risk of cerebrovascular disease and cognitive impairment: Potential mechanisms
Authors: Beckett Ashtin G. , McFadden Mia D. , Warrington Junie P.
Published: March 2023

Hypertensive disorders of pregnancy such as preeclampsia, eclampsia, superimposed preeclampsia, and gestational hypertension are major causes of fetal and maternal morbidity and mortality. Women with a history of hypertensive pregnancy disorders have increased risk of stroke and cognitive impairments later in life. Moreover, women with a history of preeclampsia have increased risk of mortality from diseases including stroke, Alzheimer’s disease, and cardiovascular disease. The underlying pathophysiological mechanisms are currently not fully known. Here, we present clinical, epidemiological, and preclinical studies focused on evaluating the long-term cerebrovascular and cognitive dysfunction that affect women with a history of hypertensive pregnancy disorders and discuss potential underlying pathophysiological mechanisms.
Promote identification or prevent expansion? The effect of uploader-viewer similarity on viewer inspiration in the context of short video community
Authors: Fu Senhui , Dai Haiwen
Published: March 2023

Introduction

Short video communities have proliferated recently, opening up a new channel for the promotion of online businesses. The main challenge in marketing with short videos is how to inspire consumers.

Methods

This study employs viewer social identification and self-expansion as its entrance point to to explain how uploader-viewer similarity affects viewers’ short video inspiration. We use empirical investigation method based on the data of 310 short video viewers to test our conceptual model.

Results

We found that there is a double-edged relationship between uploader-viewer similarity and short video inspiration. Particularly, uploader-viewer similarity enhances perceived social identification while reducing perceived self-expansion. The association between Uploader-viewer similarity and short video inspiration is moderated by viewers’ cognitive demands.

Discussion

These results provide a new perspective for enterprises to manage the relationship between viewers and media.
CARMA II: A ground vehicle for autonomous surveying of alpha, beta and gamma radiation
Authors: Nouri Rahmat Abadi Bahman , West Andrew , Peel Harriet , Nancekievill Matthew , Ballard Christopher , Lennox Barry , Marjanovic Ognjen , Groves Keir
Published: March 2023

Surveying active nuclear facilities for spread of alpha and beta contamination is currently performed by human operators. However, a skills gap of qualified workers is emerging and is set to worsen in the near future due to under recruitment, retirement and increased demand. This paper presents an autonomous ground vehicle that can survey nuclear facilities for alpha, beta and gamma radiation and generate radiation heatmaps. New methods for preventing the robot from spreading radioactive contamination using a state-machine and radiation costmaps are introduced. This is the first robot that can detect alpha and beta contamination and autonomously re-plan around the contamination without the wheels passing over the contaminated area. Radiation avoidance functionality is proven experimentally to reduce alpha and beta contamination spread as well as gamma radiation dose to the robot. The robot’s survey area is defined using a custom designed, graphically controlled area coverage planner. It was concluded that the robot is highly suited to certain monotonous room scale radiation surveying tasks and therefore provides the opportunity for financial savings, to mitigate a future skills gap, and provision of radiation surveys that are more granular, accurate and repeatable than those currently performed by human operators.
Cooking properties and nutrient retention of biofortified common bean (Phaseolus vulgaris) varieties: The case of Burundi
Authors: Muroki Mary W. , Waswa Lydiah M. , Fungo Robert , Kabwama Andrew , Mahungu Symon M.
Published: March 2023

Introduction

Current research on micronutrient deficiency indicates positive outcomes associated with utilizing biofortified beans in mitigating nutrition-related iron and zinc deficiencies, primarily in Sub-Saharan Africa. The common bean is however not palatable in its raw state and requires cooking before consumption. Existing research on the cooking qualities and nutrient retention of these novel biofortified common bean varieties is nonetheless scant, notably in Burundi.

Materials and methods

This study determined water absorption capacity, cooking yield, cooking time, and iron and zinc retention of 9 biofortified common bean varieties with Kinure, a traditional non-biofortified variety, as the control. The study employed a 10 × 2 completely randomized design in a factorial arrangement. The first factor was bean varieties with ten levels, and the second was pre-treatment with two levels, soaking and not soaking. Standard methods were used to analyze cooking properties and mineral retention, and experiments replicated thrice. Data analysis was conducted at a 95% confidence level and included Analysis of Variance and t-test comparison studies. Post-hoc analysis was performed using Tukey's Honestly Significant Difference.

Results and discussion

Cooking properties and mineral retention varied significantly between soaked and unsoaked bean varieties (P < 0.05) and in comparison, to Kinure (P < 0.05 and P < 0.001). Water absorption capacity varied from 64.51% to 116.3%. Soaked beans recorded half the total cooking time needed to cook unsoaked beans (77.62 versus 156.86 minutes), had higher cooking yields (289.77% versus 259.82%), and reduced Fe (121.58 versus 167.8%) and Zn (127.74% versus 145.15%) retention. Compared to Kinure, soaking resulted in longer cooking times, lower cooking yields in the biofortified common beans, and an insignificant effect on their zinc retention. A significant correlation between iron and zinc retention (r = 0.445), water absorption capacity and iron retention (r = −0.0425) and water absorption capacity and zinc retention (r = −0.477) were recorded. Three clusters were also observed; iron and zinc retention, cooking yields, and water absorption capacity, and cooking time. It was observed that, soaking common beans before cooking reduces cooking time and increases cooking yield in both biofortified and traditional common bean varieties. Moreover, biofortified common beans are a good source of iron and zinc and could considerably alleviate micronutrient deficiencies, particularly in developing countries.
Leiomyoma of the fallopian tube found during laparoscopic myomectomy: A case report and review of the literature
Authors: Cheng Bing , Wang Rui , Fu Yaoqun , Fu Xi
Published: March 2023

Leiomyoma of the fallopian tube is an extremely rare benign tumor of the fallopian tube. Because of the small number of cases, it is difficult to calculate their incidence. In this case report, we report a case of leiomyoma of the fallopian tube detected during laparoscopic myomectomy in a 31-year-old female with occasional pelvic pain. The patient was diagnosed with uterine leiomyoma based on a transvaginal ultrasound scan. She was operated and a 3*3 cm mass in the area of the isthmus of the left fallopian tube was observed. Three uterine leiomyomas and one leiomyoma of the fallopian tube were removed. Ultrasound at 6 months postoperatively showed no abnormality. Hysterosalpingo-contrast-sonography (HyCoSy) at 15 months postoperatively showed bilateral fallopian tubes were unobstructed. For those patients with fertility requirements, some fertility-preserving techniques can be used to allow complete resection of the leiomyoma and avoid tubal damage.
Pinniped electroencephalography: Methodology and findings in California sea lions (Zalophus californianus)
Authors: Williams D. Colette , Haulena Martin , Dennison Sophie , Waugh Lynnette , Goldstein Tracey , Nutter Felicia , Bonn Bill Van , Hoard Vanessa , Laxer Kenneth D. , Buckmaster Paul S. , Gulland Frances M. D. , Tharp Barry
Published: March 2023

This study was designed to identify abnormalities in the electroencephalograms (EEGs) recorded from stranded California sea lions (Zalophus californianus) with suspected domoic acid (DA) toxicosis. Recordings from animals presenting for non-neurological issues were also obtained to better understand the normal EEG (background activity and transient events) in this species, as, to date, studies have focused on examining natural sleep in pinnipeds. Most animals were sedated for electrode placement and EEG acquisition with some receiving antiepileptic medications or isoflurane during the procedure. A total of 103 recordings were read and scored from 0 (normal) to 3 (severely abnormal). Epileptiform discharges, consisting of spikes, sharp waves, slow waves, and/or spike waves, were present in all EEGs with scores of 1, 2, or 3. The distribution of these events over the scalp varied. While often generalized, others were lateralized over one hemisphere, bifrontal, bioccipital, and/or bitemporal, while some discharges were multifocal. Findings were different between sea lions and occasionally changed within the EEG on a given sea lion. No clinical seizures were observed during the recording but a few sea lions had findings consistent with electroencephalographic seizures. When available, supporting diagnostic results obtained from magnetic resonance imaging (MRI) and/or necropsy/histopathology were described, as well as the status of those sea lions that recovered and were released with satellite tags.
Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats
Authors: Alsharif Khalaf F. , Elmahallawy Ehab Kotb , Alblihd Mohamed A. , Hamad Asmaa A. , Nasreldin Nani , Alsanie Walaa , Aljoudi Ahmad Majed , Oyouni Atif Abdulwahab A. , Al-Amer Osama M. , Albarakati Alaa Jameel A. , Lokman Maha S. , Albrakati Ashraf , Ali Fatma Abo Zakaib
Published: March 2023

Melatonin possesses a wide range of pharmacological activities, including antidiabetic properties. Diabetes mellitus (DM) induces several physiopathological changes in body organs, which could be observed lately after systemic failure. In the current study, we aimed to investigate the serobiochemical changes and the histopathological picture in the diabetic heart and the kidney early before chronic complications and highlight the association between hyperglycemia, glomerular alterations, and cardiovascular changes. In addition, the role of melatonin in the treatment of cardio-nephro diabetic vascular and cellular adverse changes in streptozotocin-induced diabetic rats was also studied. A total of 40 mature Wistar albino rats were distributed into five groups; (1) control untreated rats, (2) diabetic mellitus untreated (DM) rats, in which DM was induced by the injection of streptozotocin (STZ), (3) control melatonin-treated (MLT), (4) melatonin-treated diabetic (DM + MLT) rats, in which melatonin was injected (10 mg/kg/day, i.p.) for 4 weeks, and (5) insulin-treated diabetic (DM + INS) rats. The serum biochemical analysis of diabetic STZ rats showed a significant (P < 0.05) increase in the concentrations of blood glucose, total oxidative capacity (TOC), CK-MB, endothelin-1, myoglobin, H-FABP, ALT, AST, urea, and creatinine as compared to control rats. In contrast, there was a significant (P < 0.05) decrease in serum concentration of insulin, total antioxidative capacity (TAC), total nitric oxide (TNO), and total protein level in DM rats vs. the control rats. Significant improvement in the serobiochemical parameters was noticed in both (DM + MLT) and (DM + INS) groups as compared with (DM) rats. The histological examination of the DM group revealed a disorder of myofibers, cardiomyocyte nuclei, and an increase in connective tissue deposits in between cardiac tissues. Severe congestion and dilation of blood capillaries between cardiac muscle fibers were also observed. The nephropathic changes in DM rats revealed various deteriorations in glomeruli and renal tubular cells of the same group. In addition, vascular alterations in the arcuate artery at the corticomedullary junction and interstitial congestion take place. Melatonin administration repaired all these histopathological alterations to near-control levels. The study concluded that melatonin could be an effective therapeutic molecule for restoring serobiochemical and tissue histopathological alterations during diabetes mellitus.
Non-Genetic Factors and Risk of Cervical Cancer: An Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies
Authors: Li Xin-Yu , Li Gang , Gong Ting-Ting , Lv Jia-Le , Gao Chang , Liu Fang-Hua , Zhao Yu-Hong , Wu Qi-Jun
Published: March 2023

Objectives: The association between non-genetic risk factors and cervical cancer (CC) remains controversial and unclear. This umbrella review was conducted to evaluate and synthesize previously published systematic reviews and meta-analyses related to non-genetic factors and CC risk.

Methods: We searched PubMed, Web of Science, and EMBASE to identify studies investigating the association between extragenetic factors and CC risk. For each article, we calculated the summary effect size and the 95% confidence interval. Specific criteria were used to classify the association into four levels: strong, highly suggestive, suggestive, or weak.

Results: A total of 18 meta-analyses of different risk factors for CC were examined; these studies covered risk factors related to diet, lifestyle, reproduction, disease, viral infection, microorganisms, and parasites. Oral contraceptive use and Chlamydia trachomatis infection were shown to increase CC risk, and this was supported by strong evidence. Additionally, there were four risk factors supported by highly suggestive evidence and six risk factors supported by suggestive evidence.

Conclusion: In conclusion, there is a strong association between oral contraceptive use, Chlamydia trachomatis infection, and increased CC risk.
Changes in Soil C and N Stocks and Their Effects on Rice Yield under Long-Term Upland-Paddy Rotations
Authors: Wang Mengjia , Feng Xiangqian , Ma Hengyu , Wang Danying , Chen Song
Published: March 2023

Observations of the effects of long-term paddy-upland rotations on soil carbon (C) and nitrogen (N) stocks are scarce. This experiment aimed to examine soil C and N stock characteristics and their relationships with rice yield using four long-term rotation systems. The results showed that in the topsoil at 50 cm, compared to rice-fallow (RF), rice-potato with rice straw mulch and return (RP) and rice-Chinese milk vetch (RC) increased soil organic carbon (SOC) stock by 19.67% and 15.29%, total nitrogen (TN) stock by 20.40% and 18.54%, and available nitrogen (AN) density by 61.54% and 34.44%, respectively; while rice-wheat (RW) increased AN density by 30.24%. Furthermore, the increases in densities of soil C and N at 20–30 cm were likely to increase rice above biomass and yield. The highest soil C and N densities were observed in RP, which was the best choice for increasing soil nutrients and rice yield. In addition, SOC, TN, and AN had obvious stratification and surface aggregation characteristics, and more than 70% of the total stocks were concentrated at the top 30 cm. These results provide a theoretical basis for the high-yield cultivation of rice in the middle and lower reaches of the Yangtze River.
Metal Composition and Source Identification of PM2.5 and PM10 at a Suburban Site in Pathum Thani, Thailand
Authors: Nuchdang Sasikarn , Kingkam Wilasinee , Tippawan Udomrat , Sriwiang Wiranee , Fungklin Ratchai , Rattanaphra Dussadee
Published: March 2023

This study reports the mass concentrations, elemental characterization and identification of the possible sources of PM2.5 and PM10 at a suburban site in Pathum Thani, Thailand. The sampling was done from 18 February 2021 to 14 September 2021. PM2.5 concentrations were between 0.39 μg/m3 and 174.26 μg/m3, while PM10 concentration ranged from 12.75 μg/m3 to 242.02 μg/m3. The average concentration of PM2.5 in the wet season (61.96 μg/m3) in the study area exceeded the national ambient air quality standards (NAAQS). Particle-induced X-ray emission (PIXE) was used to measure the element concentrations. The main elements, namely Fe, K, Cr and Ca, in both PM2.5 and PM10 showed significantly higher concentrations in the summer season. A qualitative inter-elemental correlation analysis, principal component analysis (PCA) and cluster analysis (CA) were applied for source identification of PM2.5 and PM10. The results for the three procedures were in good agreement. Four and three factors of sources were isolated by the PCA for PM2.5 and PM10, respectively. The main sources identified by PCA were, for PM2.5, soil dust and biomass burning (32%), road dust and industrial emission (25%), vehicle and industrial emission (10%) and soil dust (9%); for PM10, road dust and industrial emission (36%), crustal and biomass burning (30%) and industrial sources (10%).
Material and Waste Flow Analysis for Environmental and Economic Impact Assessment of Inorganic Acid Leaching Routes for Spent Lithium Batteries’ Cathode Scraps
Authors: Tang Yi-Chin , Wang Jian-Zhi , Chou Chih-Ming , Shen Yun-Hwei
Published: March 2023

With the development trend and technological progress of lithium batteries, the battery market is booming. This means that the demand for lithium batteries has increased significantly, resulting in a large number of discarded lithium batteries. The consumption of plenty of lithium batteries may lead to the scarcity and expending of relevant raw material metal resources, as well as serious heavy metal environmental pollution. Therefore, it is of great significance to recycle valuable metal resources from discarded lithium batteries. The proper recycling of these valuable metals can reduce the shortage of mineral resources and environmental hazards caused by a large number of scrapped vehicle batteries. Recently, different systematic approaches have been developed for spent lithium battery recovery. However, most of these approaches do not account for the hidden costs incurred from various processing steps. This work is determined by the concept of material flow cost accounting (MFCA). Hence, in this research, a MFCA-based approach is developed for the leaching process of spent lithium batteries recovery, taking into consideration the hidden costs embedded in process streams. In this study, hydrochloric acid had the worst leaching efficiency due to its high solid-to-liquid ratio and the lowest acid concentration, so it was excluded in the first stage selection. It takes TWD 16.03 and TWD 24.10 to leach 10 g of lithium battery powder with sulfuric acid and nitric acid, respectively. The final sulfuric acid was the acid solution with the highest leaching efficiency and relatively low cost among inorganic acids.
Hybrid Energy Storage Systems Based on Redox-Flow Batteries: Recent Developments, Challenges, and Future Perspectives
Authors: Schubert Christina , Hassen Wiem , Poisl Barbara , Seitz Stephanie , Schubert Jonathan , Oyarbide Usabiaga Estanis , Gaudo Pilar , Pettinger Karl-Heinz
Published: March 2023

Recently, the appeal of Hybrid Energy Storage Systems (HESSs) has been growing in multiple application fields, such as charging stations, grid services, and microgrids. HESSs consist of an integration of two or more single Energy Storage Systems (ESSs) to combine the benefits of each ESS and improve the overall system performance, e.g., efficiency and lifespan. Most recent studies on HESS mainly focus on power management and coupling between the different ESSs without a particular interest in a specific type of ESS. Over the last decades, Redox-Flow Batteries (RFBs) have received significant attention due to their attractive features, especially for stationary storage applications, and hybridization can improve certain characteristics with respect to short-term duration and peak power availability. Presented in this paper is a comprehensive overview of the main concepts of HESSs based on RFBs. Starting with a brief description and a specification of the Key Performance Indicators (KPIs) of common electrochemical storage technologies suitable for hybridization with RFBs, HESS are classified based on battery-oriented and application-oriented KPIs. Furthermore, an optimal coupling architecture of HESS comprising the combination of an RFB and a Supercapacitor (SC) is proposed and evaluated via numerical simulation. Finally, an in-depth study of Energy Management Systems (EMS) is conducted. The general structure of an EMS as well as possible application scenarios are provided to identify commonly used control and optimization parameters. Therefore, the differentiation in system-oriented and application-oriented parameters is applied to literature data. Afterwards, state-of-the-art EMS optimization techniques are discussed. As an optimal EMS is characterized by the prediction of the system’s future behavior and the use of the suitable control technique, a detailed analysis of the previous implemented EMS prediction algorithms and control techniques is carried out. The study summarizes the key aspects and challenges of the electrical hybridization of RFBs and thus gives future perspectives on newly needed optimization and control algorithms for management systems.
Utilizing Computational Modelling to Bridge the Gap between In Vivo and In Vitro Degradation Rates for Mg-xGd Implants
Authors: Al Baraghtheh Tamadur , Hermann Alexander , Shojaei Arman , Willumeit-Römer Regine , Cyron Christian J. , Zeller-Plumhoff Berit
Published: March 2023

Magnesium (Mg) and its alloys are promising materials for temporary bone implants due to their mechanical properties and biocompatibility. The most challenging aspect of Mg-based implants involves adapting the degradation rate to the human body, which requires extensive in vitro and in vivo testing. Given that in vivo tests are significantly more labour-intensive than in vitro and ethics prohibit direct experiments on animals or humans, attempts are commonly undertaken to infer conclusions on in vivo degradation behavior from in vitro experiments. However, there is a wide gap between these tests, and in vitro testing is often a poor predictor of in vivo outcomes. In the development of biodegradable Mg-based implants, considerable efforts are being made to reduce the overall time and cost of in vitro and in vivo testing. Finding a suitable alternative to predict the degradation of Mg alloys, however, remains challenging. We present computational modelling as a possible alternative to bridge the gap between in vitro and in vivo testing, thus reducing overall cost, duration and number of experiments. However, traditional modelling approaches for complex biodegradable systems are still rather time-consuming and require a clear definition of the relations between input parameters and the model result. In this study, Kriging surrogate models based on the peridynamic in vitro degradation model were developed to simulate the degradation behavior for two main alloys, Mg-5Gd and Mg-10Gd, for both in vitro and in vivo cases. Using Kriging surrogate models, the simulation parameters were calibrated to the volume loss data from in vitro and in vivo experiments. In vivo degradation of magnesium has one order of magnitude higher apparent diffusion coefficients than in vitro degradation, thus yielding the higher volume loss observed in vivo than in vitro. On the basis of the diffusivity of the Mg2+ ions modeled under in vitro degradation, Kriging surrogate models were able to simulate the in vivo degradation behavior of Mg-xGd with a ratio between 0.46 and 0.5, indicating that the surrogate-modelling approach is able to bridge the gap between in vitro and in vivo degradation rates for Mg-xGd implants.
Impact of Hydrophobic and Electrostatic Forces on the Adsorption of Acacia Gum on Oxide Surfaces Revealed by QCM-D
Authors: Davantès Athénaïs , Nigen Michaël , Sanchez Christian , Renard Denis
Published: March 2023

The adsorption of Acacia gum from two plant exudates, A. senegal and A. seyal, at the solid-liquid interface on oxide surfaces was studied using a quartz crystal microbalance with dissipation monitoring (QCM-D). The impact of the hydrophobic and electrostatic forces on the adsorption capacity was investigated by different surface, hydrophobicity, and charge properties, and by varying the ionic strength or the pH. The results highlight that hydrophobic forces have higher impacts than electrostatic forces on the Acacia gum adsorption on the oxide surface. The Acacia gum adsorption capacity is higher on hydrophobic surfaces compared to hydrophilic ones and presents a higher stability with negatively charged surfaces. The structural configuration and charge of Acacia gum in the first part of the adsorption process are important parameters. Acacia gum displays an extraordinary ability to adapt to surface properties through rearrangements, conformational changes, and/or dehydration processes in order to reach the steadiest state on the solid surface. Rheological analysis from QCM-D data shows that the A. senegal layers present a viscous behavior on the hydrophilic surface and a viscoelastic behavior on more hydrophobic ones. On the contrary, A. seyal layers show elastic behavior on all surfaces according to the Voigt model or a viscous behavior on the hydrophobic surface when considering the power-law model.
On the Development of an Implicit Discontinuous Galerkin Solver for Turbulent Real Gas Flows
Authors: Mantecca Edoardo , Colombo Alessandro , Ghidoni Antonio , Noventa Gianmaria , Pasquale David , Rebay Stefano
Published: March 2023

The aim of this work is to describe an efficient implementation of cubic and multiparameter real gas models in an existing discontinuous Galerkin solver to extend its capabilities to the simulation of turbulent real gas flows. The adopted thermodynamic models are van der Waals, Peng–Robinson, and Span–Wagner, which differ from each other in terms of accuracy and computational cost. Convective numerical fluxes across elements interfaces are calculated with a thermodynamic consistent linearized Riemann solver, whereas for boundary conditions, a linearized expression of the generalized Riemann invariants is employed. Transport properties are treated as temperature- and density-dependent quantities through multiparameter correlations. An implicit time integration is adopted; Jacobian matrix and thermodynamic derivatives are obtained with the automatic differentiation tool Tapenade. The solver accuracy is assessed by computing both steady and unsteady real gas test cases available in the literature, and the effect of the mesh size and polynomial degree of approximation on the solution accuracy is investigated. A good agreement with experimental and numerical reference data is observed and specific non-classical phenomena are well reproduced by the solver.
On the Solutions of a Class of Discrete PWC Systems Modeled with Caputo-Type Delta Fractional Difference Equations
Authors: Danca Marius-F. , Jonnalagadda Jagan Mohan
Published: March 2023

In this paper, it is shown that a class of discrete Piece Wise Continuous (PWC) systems with Caputo-type delta fractional difference may not have solutions. To overcome this obstacle, the discontinuous problem is restarted as a continuous fractional problem. First, the single-valued PWC problem is transformed into a set-valued one via Filippov’s theory, after which Cellina’s theorem allows the restart of the problem into a single-valued continuous one. A numerical example is proposed and analyzed.
Identifying Soccer Teams’ Styles of Play: A Scoping and Critical Review
Authors: Plakias Spyridon , Moustakidis Serafeim , Kokkotis Christos , Tsatalas Themistoklis , Papalexi Marina , Plakias Dionysios , Giakas Giannis , Tsaopoulos Dimitrios
Published: March 2023

Identifying and measuring soccer playing styles is a very important step toward a more effective performance analysis. Exploring the different game styles that a team can adopt to enable a great performance remains under-researched. To address this challenge and identify new directions in future research in the area, this paper conducted a critical review of 40 research articles that met specific criteria. Following the 22-item Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, this scoping review searched for literature on Google Scholar, Web of Science, and Pub Med databases. The descriptive and thematic analysis found that the objectives of the identified papers can be classified into three main categories (recognition and effectiveness of playing styles and contextual variables that affect them). Critically reviewing the studies, the paper concluded that: (i) factor analysis seems to be the best technique among inductive statistics; (ii) artificial intelligence (AI) opens new horizons in performance analysis, and (iii) there is a need for further research on the effectiveness of different playing styles, as well as on the impact of contextual variables on them.
Evaluation of Posturographic and Neuromuscular Parameters during Upright Stance and Hand Standing: A Pilot Study
Authors: Thomas Ewan , Rossi Carlo , Petrigna Luca , Messina Giuseppe , Bellafiore Marianna , Şahin Fatma Neşe , Proia Patrizia , Palma Antonio , Bianco Antonino
Published: March 2023

Upright bipedal posture is the physiological human posture; however, it is not the only possible form of human standing; indeed, an inverted position, a handstand, is required during gymnastics or other sports. Thus, this study aimed to understand the differences between the two standing strategies from a postural and neuromuscular perspective. Thirteen gymnasts with at least three years of sports experience underwent a baropodometric assessment and a surface electromyography (sEMG) examination in a standard upright bipodalic stance and during a handstand. The sEMG examination was performed on the gastrocnemius during an upright stance and on the flexor carpi radialis during the handstand. Limb weight distribution presented differences between the two vertical stances (p < 0.01). During the handstand, the weight ratio was prevalently observed on the palm of the hand for both hands with a significant difference between the front and rear aspect of the hand compared to the standing tasks (p < 0.01). Normalized sEMG amplitude showed significant differences during bipedal standing and hand standing; however, over a 5 s period, the normalized median frequency (MDF) value was similar for the two tasks. Both standing tasks presented similar postural weight managing patterns when analysed on the frontal plane, but they were different on the sagittal plane. In addition, the neuromuscular patterns during a 5 s window differ in amplitude but not for the frequency domain.
New Zealand Youth Rugby Sevens: A Comparative Match Demands Study
Authors: Wintershoven Koen , Beaven Christopher Martyn , Gill Nicholas David , McMaster Daniel Travis
Published: March 2023

Rugby sevens has established itself on the world stage since its inclusion in the 2016 Olympics. Participation among New Zealand (NZ) youth has surged. Sevens games have specific high demands, but little is known about these competitive demands in regards to youth. Two NZ male youth squads (U15, n = 13; U19, n = 14) were monitored during a national sevens tournament. Microsensor technology captured heart rate (HR) and kinematic performance. The rating of perceived exertion (RPE) was collected for U15 matches only. U19 and U15 players ran 108 ± 11 and 116 ± 13 m·min−1 at an average speed (VAVG) of 6.5 ± 0.6 and 6.9 ± 0.8 km·h−1. Peak speeds (VPEAK) reached 33.7 km·h−1, and high-intensity running distance (HIRD) averaged 252 ± 102 m. U15 (44.3 ± 9.2 game−1) and U19 (39.4 ± 6.1 game−1) showed different sprint rates. U15 covered more moderate-velocity distance (20–80% VMAX) and less low-velocity distance (<20% VMAX). RPE was 13 ± 1 (U15). An average HR of 90.0 ± 3.9% HRMAX was recorded. Upwards of 57% of game time was played at >90% HRMAX. Youth sevens competition is specifically demanding. U15 can experience greater loads than older peers in rugby. Coaches can use this information to optimize players’ physical development.
Co-Carbonization of Discard Coal with Waste Polyethylene Terephthalate towards the Preparation of Metallurgical Coke
Authors: Bambalaza Sonwabo E. , Xakalashe Buhle S. , Coetsee Yolindi , van Zyl Pieter G. , Dyosiba Xoliswa L. , Musyoka Nicholas M. , Steenkamp Joalet D.
Published: March 2023

Waste plastics such as polyethylene terephthalate (w-PET) and stockpiled discard coal (d-coal) pose a global environmental threat as they are disposed of in large quantities as solid waste into landfills and are particularly hazardous due to spontaneous combustion of d-coal that produces greenhouse gases (GHG) and the non-biodegradability of w-PET plastic products. This study reports on the development of a composite material, prepared from w-PET and d-coal, with physical and chemical properties similar to that of metallurgical coke. The w-PET/d-coal composite was synthesized via a co-carbonization process at 700 °C under a constant flow of nitrogen gas. Proximate analysis results showed that a carbonized w-PET/d-coal composite could attain up to 35% improvement in fixed carbon content compared to its d-coal counterpart, such that an initial fixed carbon content of 14–75% in carbonized discard coal could be improved to 49–86% in carbonized w-PET/d-coal composites. The results clearly demonstrate the role of d-coal ash on the degree of thermo-catalytic conversion of w-PET to solid carbon, showing that the yield of carbon derived from w-PET (i.e., c-PET) was proportional to the ash content of d-coal. Furthermore, the chemical and physical characterization of the composition and structure of the c-PET/d-coal composite showed evidence of mainly graphitized carbon and a post-carbonization caking ability similar to that of metallurgical coke. The results obtained in this study show potential for the use of waste raw materials, w-PET and d-coal, towards the development of an eco-friendly reductant with comparable chemical and physical properties to metallurgical coke.
Composite p-Si/Al2O3/Ni Photoelectrode for Hydrogen Evolution Reaction
Authors: Kalinauskas Putinas , Staišiūnas Laurynas , Grigucevičienė Asta , Leinartas Konstantinas , Šilėnas Aldis , Bučinskienė Dalia , Juzeliūnas Eimutis
Published: March 2023

A photoelectrode for hydrogen evolution reaction (HER) is proposed, which is based on p-type silicon (p-Si) passivated with an ultrathin (10 nm) alumina (Al2O3) layer and modified with microformations of a nickel catalyst. The Al2O3 layer was formed using atomic layer deposition (ALD), while the nickel was deposited photoelectrochemically. The alumina film improved the electronic properties of the substrate and, at the same time, protected the surface from corrosion and enabled the deposition of nickel microformations. The Ni catalyst increased the HER rate up to one order of magnitude, which was comparable with the rate measured on a hydrogen-terminated electrode. Properties of the alumina film on silicon were comprehensively studied. Grazing incidence X-ray diffraction (GI-XRD) identified the amorphous structure of the ALD oxide layer. Optical profilometry and spectroscopic ellipsometry (SE) showed stability of the film in an acid electrolyte. Resistivity measurements showed that annealing of the film increases its electric resistance by four times.
Recrystallization of Hot-Rolled 2A14 Alloy during Semisolid Temperature Annealing Process
Authors: Liu Yingze , Jiang Jufu , Zhang Ying , Huang Minjie , Dong Jian , Wang Ying
Published: March 2023

In this study, in order to provide proper parameters for the preparation of semisolid billets, the semisolid annealing of hot-rolled 2A14 Al alloy was investigated. The microstructure was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) with an X-ray energy dispersive spectrometer (EDS) and electron backscattered diffraction (EBSD), and scanning transmission electron microscopy (STEM). The XRD results showed that, with an increase in temperature, the θ-Al2Cu equilibrium gradually dissolved in the matrix. The EDS results of SEM and STEM showed a coarse θ-Al2Cu phase, ultrafine precipitate Al(MnFeSi) or (Mn, Fe)Al6 phase, and atomic clusters in the microstructure. The EBSD results showed that the recrystallization mechanism was dominated by continuous static recrystallization (CSRX), homogeneous nucleation occurred when the sample was heated to near solidus temperature, and CSRX occurred at a semisolid temperature. In the process of recrystallization, the microtexture changed from the preferred orientation to a random orientation. Various experimental results showed that static recrystallization (SRX) occurred at a semisolid temperature due to the blocking effect of atomic clusters on the dislocation slip, and the Zener drag effect of fine precipitates on low-angle grain boundaries (LAGBs) disappeared with melting at a semisolid temperature.
Reuse of Oil Refining Sludge Residue Ash via Alkaline Activation in Matrices of Chamotte or Rice Husk Ash
Authors: García-Díaz Almudena , Bueno-Rodríguez Salvador , Pérez-Villarejo Luis , Eliche-Quesada Dolores
Published: March 2023

The aim of this work is to investigate the possibility of reusing ashes obtained by the calcination of industrial sludge from the oil refining industry (ORSA) as a secondary raw material in the manufacture of alkaline activated cements or geopolymers. The incorporation behavior of 5–20 wt.% of residue in binary mixtures with rice husk ash (RHA) or chamotte (CHM) was evaluated. The cements were activated with a sustainable alternative activating solution obtained from NaOH (10 M) and diatomaceous earth. The specimens were cured at room temperature. Physical and mechanical properties were determined, and the reaction products were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy–energy dispersive X-ray spectroscopy (SEM-EDX). The results indicate that the addition of ORSA (5–20 wt.%) to RHA and CHM improves the mechanical strength of alkaline activated cements with maximum compressive strengths of 30.6 MPa and 15.7 MPa, respectively, after 28 days of curing, with the incorporation of 20 wt.% waste. In these mixtures, the sludge acts as a source of aluminum, promoting the formation of a higher amount of geopolymer gel N-A-S-H in materials using RHA as a precursor and also (N)-(C)-A-S-H gel in cements using CHM.
Investigation on Preparation and Performance of High Ga CIGS Absorbers and Their Solar Cells
Authors: Lv Xiaoyu , Zheng Zilong , Zhao Ming , Wang Hanpeng , Zhuang Daming
Published: March 2023

Tandem solar cells usually use a wide band gap absorber for top cell. The band gap of CuIn(1−x)GaxSe2 can be changed from 1.04 eV to 1.68 eV with the ratio of Ga/(In+Ga) from 0 to 1. When the ratio of Ga/(In+Ga) is over 0.7, the band gap of CIGS absorber is over 1.48 eV. CIGS absorber with a high Ga content is a possible candidate one for the top cell. In this work, CuInGa precursors were prepared by magnetron sputtering with CuIn and CuGa targets, and CIGS absorbers were prepared by selenization annealing. The Ga/(In+Ga) is changed by changing the thickness of CuIn and CuGa layers. Additionally, CIGS solar cells were prepared using CdS buffer layer. The effects of Ga content on CIGS thin film and CIGS solar cell were studied. The band gap was measured by PL and EQE. The results show that using structure of CuIn/CuGa precursors can make the band gap of CIGS present a gradient band gap, which can obtain a high open circuit voltage and high short circuit current of the device. With the decrease in Ga content, the efficiency of the solar cell increases gradually. Additionally, the highest efficiency of the CIGS solar cells is 11.58% when the ratio of Ga/(In+Ga) is 0.72. The value of Voc is 702 mV. CIGS with high Ga content shows a great potential for the top cell of the tandem solar cell.
Assessment of Oral Health Knowledge, Attitude, Practice and DMFT Scores among Patients at King Faisal University, Al-Ahsa
Authors: Ahmed Muhammad Adeel , Jouhar Rizwan , Faheemuddin Muhammad , AlJafar Ahmed , Alabawi Hussain , Alhumaidi Baqer , Al Madeh Moaiad
Published: March 2023

Background and Objectives: Oral health is one of the most significant issues in public health. The Decayed, Missing, and Filled Teeth (DMFT) Index is a useful tool for assessing and measuring the state of oral health in a community. This study aimed to evaluate oral health knowledge, attitudes, and practices among participants who visited a dental clinic at King Faisal University and to evaluate their DMFT scores. Materials and Methods: This cross-sectional, questionnaire-based study was conducted at the King Faisal University dental complex, Kingdom of Saudi Arabia, using a simple random sampling technique. The data were collected using a self-administered structured questionnaire in English and Arabic. All statistical analyses were carried out using the SPSS 20 software. A chi square and ANOVA test were used to assess the association. A p value of <0.05 was considered statistically significant. Results: There were a total of 260 participants, of whom 193 (74.2%) were male and 67 (25.8%) were female. Most participants, 173 (66.5%), were between the ages of 18 and 28. The majority of the participants 191 (73.5%) believed that bad oral hygiene led to gum disease. Additionally, major issues while visiting dental clinics, the importance of routine dental clinic visits, the existence of a connection between oral and general health, brushing time and frequency of change of used brush were significantly influenced by gender (p < 0.05). In terms of the DMFT index, mean numbers of decaying teeth (D) were 4.82 ± 4.15, mean numbers of missing teeth (M) were 1.56 ± 2.94, mean numbers of filled teeth (F) were 5.17 ± 5.28 and mean DMFT score was 11.56 ± 6.32, with a statistically significant difference observed (p < 0.001). Conclusions: This study concluded that, although some of the study participants neglected oral hygiene practices, the majority of participants had good knowledge and attitudes regarding the significance of oral hygiene. Owing to inadequate practices, the decayed, missing, and filled teeth scores increased with increasing age. Additionally, gender had no significant impact on the mean scores for decayed, missing, and filled teeth, although there were significant differences between age groups.
Management of Pyometra Using a Novel Image-Guided Percutaneous Technique: A Case Report
Authors: Al-Sharydah Abdulaziz Mohammad , AlMulhim Abdulaziz Abdullah , Al Shikmubarak Ibrahim Abdulhakim , Alhussaini Abdulmohsen Ahmed , Alehaideb Raghad Sulaiman , Salman Refaat
Published: March 2023

Pyometra is a uterine infection that causes pus to accumulate in the uterine cavity. Pyometra primarily affects postmenopausal women. Multiple aetiologies, including cervical stenosis, have been identified. Medical therapy using intravenous antibiotics and surgical evacuation are the conventional treatment options for pyometra. Here, we present a unique case of a novel therapy for pyometra in a geriatric patient; percutaneous alleviation of the causative cervical stenosis was performed using balloon dilatation, along with endometrial drainage of the infected fluid through her vagina, a natural route. This technique has overcome the need for other invasive therapies. The patient’s clinical condition improved significantly after this minimally invasive treatment. Percutaneous balloon dilatation of the cervix for stenosis or occlusion in patients with pyometra facilitates drainage of the infected endometrial fluid. This alternative management technique ensured a satisfactory postoperative course and tolerance in the short-term follow-up. Furthermore, the technique ensured good aesthetic results, with its minimally invasive approach in selected patients, compared to other means of evacuation.