bluuebunny/crossref_metadata_2025 huggingface dataset:
Kesalahan Penggunaan Kata Ganti Demonstratif Ko-So-A pada Kalimat Bahasa Jepang dalam Ujian Akhir Semester Penerjemahan Lisan
Authors: Winingsih Irma
Published: September 2020

AbstractBunmyakushiji type of â€˜Ko-So-Aâ€™ demontrative pronouns are words that are being used to replace word(s) or to refer word(s) or thing(s) which have said before. The Ko-So-A demonstrative pronouns have difference usage with pronoun in Indonesian language. Writer found out there are many Japanese learners in Japanese Language Department of Dian Nuswantoro University including were having difficulties to distinguish functions of each pronoun. Because of that, writer is interested in analyzing the errors made by learner when using bunmyakushiji type of demonstrative pronoun. Writer use qualitative method and analytic descriptive. The data were collected from conversations ofÂ  Interpreting classâ€™s Final Exam. The result was error usage of So and A demonstrative pronouns often happened than error usage of Ko and So demonstrative pronouns. Â Keywords: kosoa, error, demonstrative, understanding.Â AbstrakKata ganti demonstratif Ko-So-A yang berfungsi kontekstual digunakan untukmerujuk atau menggantikan kata yang dituturkan sebelumnya. Penggunaannyaberbeda dengan kata ganti demonstrative dalam bahasa Indonesia.Karena dalamUjian Akhir Semester mata kuliah Penerjemahan Lisan yang merupakan percakapan antara penguji dengan mahasiswa cukup banyak ditemukan kesalahan penggunaan kata ganti ini, maka penulis tertarik untuk meneliti kesalahan tersebut.Metode yang digunakan adalah metode kualitatif dengan analisis deskriptif. Data diperoleh dari percakapan/tanya jawab dalam ujian. Hasilnya yaitu kesalahan penggunaan kata ganti demonstrative So dan A lebih banyak ditemukan dibandingkan kesalahan penggunaan kata ganti demonstratif Ko dan So. Kata Kunci: ko-so-a, kesalahan, demonstratif, pemahaman
Analisis Sosiolinguistik Politeness Bahasa Jepang dalam Film Galileo 2013 Karya Keigo Higashino
Authors: Fadhillah Yuniati
Published: September 2020

ABSTRACTThis research discusses the various languages of respect (keigo), namely sonkeigo, kenjougo, and teineigo.  This study aims to examine the use of keigo language and the factors that influence the use of keigo, especially in the work environment.  The theory used in this study is based on Sachiko's sociolinguistic theory of distance.  The data used is a Japanese film entitled Galileo 2013 by Keigo Higashino.  The research method of this study show uses descriptive qualitative method.  The results of this study show that the use of respectful language keigo (kenjougo and teineigo) is used between participants in the scope of uchi mono.  Whereas the use of the various keigo languages (sonkeigo) is used by speakers of speech partners in the scope of soto mono, formal or informal situations, age or higher position.  Factors that influence the use of keigo according to Sachiko's Idea theory are the factors that take into consideration of the use of keigo in the uchi mono group is social distance, because the speaker speaks to the speech partner, based on position or age position.  Whereas the dominant factor that becomes a consideration for the use of keigo in the soto mono group is social distance and formality distance, because the speech partners who speak with many speakers do not use a variety of respectful languages (keigo), because the speech partners feel they are older than the speakers, and consider not  formal talks because it's not from his job.Keywords: Keigo, social factors, distance, uchi mono, soto mono.
Applying rasch model: adversity quotient analysis of students in mathematics
Authors: Alyani Fitri , Zahra Raihana
Published: September 2020

Penelitian ini bertujuan untuk menganalisis Adversity Quotient siswa dalam pelajaran matematika menggunakan Rasch Model. Populasi dari penelitian ini adalah beberapa siswa SMA Negeri Jakarta, dengan sampel  sebanyak 98 siswa kelas 11 salah satu SMA Negeri Jakarta tahun ajaran 2019/2020. Penelitian ini merupakan penelitian deskriptif kuantitatif. Dengan instrumen non-test berupa angket Adversity Quotient yang terdiri dari 39 pernyataan dengan jawaban yang menggunakan skala likert dengan 5 pilihan jawaban dalam bentuk “sangat tidak setuju”, “tidak setuju”, “netral”, “setuju”, “sangat setuju”. Pembagian kategori Adversity Quotient berdasarkan tipe climbers, campers, dan quitters. Hasil dari penelitian ini bahwa tipe climbers adalah tipe yang paling dominan yang dimiliki siswa berdasarkan hasil penelitiannya.
Is diplomacy an Option? Finance Theory and Brexit
Authors: Howard Mark
Published: September 2020

In finance, experts have spent decades developing complex investment instruments known as Options to minimize the risk taken by investors speculating on the market. Options are highly mathematical, which suits the quantitative field of Financial Economics. However, many aspects of Options are grounded in inter-temporal philosophical concepts suitable for qualitative fields of study, including international strategy and diplomacy. This paper argues that Options Theory provides ready-made models and concepts for diplomacy in rapidly changing contexts, but has as yet been under-exploited in the field of international relations. Drawing on the work of Elie Ayache and Robert Meister, I argue that an international political Options theory is not only possible but already exists. I demonstrate this claim by applying Options Theory to anticipated negotiations and strategic realignments that the United Kingdom is engaging in as the reality of Brexit approaches its denouement amidst a disintegrating Western Liberal Democratic alliance.
Investigation of the Relationship Between the Pulp Area and Chronological Age in Patients that Received and Not Received Orthodontic Treatment
Authors: UĞUR AYDIN Zeliha , DOĞAN Tülin , GÖLLER BULUT Duygu , KORKMAZ Yasemin Nur
Published: September 2020

Objective: The aim of
this study was to evaluate the relationship between chronological ages and pulp
areas of mandibular canine teeth of patients who underwent orthodontic
treatment and patients who never received orthodontic treatment.

Methods: 102 patients that completed fixed
orthodontic treatment and between the ages of 13-24 and 102 age and sex-matched
control group was included in the study. A total of 204 dental panoramic
radiographs taken with the same procedures and with the same device (Soredex;
Cranex Novus, Tuusula, Finland) were evaluated. The pulp areas of the
mandibular canine teeth were measured using the Image J software (US National
Institutes of Health, Bethesda, MD). Data were analyzed with Independent t-test
and Pearson’s rank correlation test.

Results: In both the orthodontic group (r =
-0,511) and in the control group (r = -0,592), there was a negative correlation
between chronological age and pulp area. There was no significant difference
between the groups with respect to the pulp area and gender (p> 0.05).

Conclusions: Orthodontic
treatment did not result in a significant difference in the correlation between
the pulp area and the chronological age.
Flexible Working Arrangement, Stress, Worklife Balance And Motivation: Evidence From Postgraduate Students As Worker
Authors: Maharani Anita , Intan Salsabila , Mahlani Siti Afifah , Berlian Christian Wahyu
Published: September 2020

The purpose of this research is to examine the effect of Flexible Working Arrangement (FWA) and Stress toward Work-Life Balance (WLB). The effect of those two variables, however, is strengthened by motivation. The goal is to provide a better understanding of the Work-Life Balance of Postgraduate students who fulfil multiple roles in their life, managing between academic, work, and family life. The survey used questionnaires for data collection in this research. A quantitative approach uses to analyze the data. The subjects of our sample were postgraduate students at a private university, with a total of 96 respondents. To analyze the data, PLS (Partial Least Square) analysis technique was used through the SmartPLS software. Also, to test the second and third hypotheses, a robustness test was performed to assess between items in the independent, dependent, and moderator variables. Findings. The results indicated that the Flexible Working Arrangement (FWA) is not proven to have a significant effect on the Work-Life Balance of postgraduate students. This research suggests the need to see the role of motivation, and the present of motivation in individual who fulfils multiple roles in life.
The impact of Fundamental Factors on Stock Return of The Engineering and Construction Services Company
Authors: Santoso Bambang , Sidharta Eka Ananta , Wardini Amalia Kusuma
Published: September 2020

This research was conducted to analyze the impact of selected fundamental factors on stock returns of Engineering and Construction Companies listed on the Indonesia Stock Exchange (IDX) using a quantitative approach. The research population includes all Engineering and Construction Companies listed on the IDX but 10 were selected as cross-section samples using a simple random sampling technique with criteria include being listed on the IDX and having time-series financial report data for 2015Q1 - 2019Q2 period. Data were retrieved from the companies’ audited financial statements and the independent variable which is stock return was determined using Panel Data and analyzed with Multiple Regressions. Meanwhile, the model specification test was produced using the Fixed Effect Model as the fit model. Findings. The results showed several fundamental factors of CR, NPM, PBV, EPS, and ROE partially has a significant positive effect on stock returns while DER has a significant negative effect and PER has a slightly positive influence. These findings are expected to contribute positively to the development of theories concerning the financial performance of stock returns. Moreover, the managerial implication of this research is that investors can use fundamentals analysis with a focus on CR, DER, EPS, NPM, PBV, PER, and ROE as the basis for decision making due to their influence on Stock Return.
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling
Authors: Guo Wenjing , Zhang Zhishuai , Li Guihuan , Lai Xiaoju , Gu Ruonan , Xu Wanfu , Chen Hua , Xing Zhe , Chen Liping , Qian Jiabi , Xu Shiyuan , Zeng Fangyin , Deng Fan
Published: September 2020

Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in many tumor cells, and has emerged as an important player in tumor progression and metastasis. However, the functional roles of PKM2 in tumor metastasis remain elusive. Here we showed that PKM2 promoted prostate cancer metastasis via extracellular-regulated protein kinase (ERK)–cyclooxygenase (COX-2) signaling. Based on public databases, we found that PKM2 expression was upregulated in prostate cancer and positively associated with tumor metastasis. Further analysis showed that PKM2 promoted prostate cancer cell migration/invasion and epithelial–mesenchymal transition (EMT) through upregulation of COX-2. Mechanistically, PKM2 interacted with ERK1/2 and regulated its phosphorylation, leading to phosphorylation of transcription factor c-Jun, downstream of ERK1/2, to activate COX-2 transcription by IP and ChIP assay, while inhibition of COX-2 significantly reversed the promotion effect of PKM2 on tumor metastasis in vivo. Taken together, our results suggest that a novel of PKM2–ERK1/2–c-Jun–COX-2 axis is a potential target in controlling prostate cancer metastasis.
The Work of Art Criticism: Collaboration, Communication, Community
Authors: Bowman Matthew
Published: September 2020

This essay aims to reconsider the practice of art criticism. The first part aims to clear away some misconceptions that reduce art criticism to a fundamentally negative discourse that asserts a theory/practice distinction. In the second part, the essay tries to think of art criticism as collaborative writing alongside rather than about an artist. The third part, however, highlights some problems insofar as communication and collaboration have become imbricated within post-Fordist socioeconomic frameworks. In addition, the fourth part seeks to propose another direction by suggesting why art criticism and Kantian aesthetics may discover a renewed interest in one another through rethinking the sensus communis as an alternative to post-Fordist sociality.
Forecasting Financial Time Series through Causal and Dilated Convolutional Neural Networks
Authors: Börjesson Lukas , Singull Martin
Published: September 2020

In this paper, predictions of future price movements of a major American stock index were made by analyzing past movements of the same and other correlated indices. A model that has shown very good results in audio and speech generation was modified to suit the analysis of financial data and was then compared to a base model, restricted by assumptions made for an efficient market. The performance of any model, trained by looking at past observations, is heavily influenced by how the division of the data into train, validation and test sets is made. This is further exaggerated by the temporal structure of the financial data, which means that the causal relationship between the predictors and the response is dependent on time. The complexity of the financial system further increases the struggle to make accurate predictions, but the model suggested here was still able to outperform the naive base model by more than 20% and 37%, respectively, when predicting the next day’s closing price and the next day’s trend.
Estimating Postural Stability Using Improved Permutation Entropy via TUG Accelerometer Data for Community-Dwelling Elderly People
Authors: Lee Chia-Hsuan , Chen Shih-Hai , Jiang Bernard C. , Sun Tien-Lung
Published: September 2020

To develop an effective fall prevention program, clinicians must first identify the elderly people at risk of falling and then take the most appropriate interventions to reduce or eliminate preventable falls. Employing feature selection to establish effective decision making can thus assist in the identification of a patient’s fall risk from limited data. This work therefore aims to supplement professional timed up and go assessment methods using sensor technology, entropy analysis, and statistical analysis. The results showed the different approach of applying logistic regression analysis to the inertial data on a fall-risk scale to allow medical practitioners to predict for high-risk patients. Logistic regression was also used to automatically select feature values and clinical judgment methods to explore the differences in decision making. We also calculate the area under the receiver-operating characteristic curve (AUC). Results indicated that permutation entropy and statistical features provided the best AUC values (all above 0.9), and false positives were avoided. Additionally, the weighted-permutation entropy/statistical features test has a relatively good agreement rate with the short-form Berg balance scale when classifying patients as being at risk. Therefore, the proposed methodology can provide decision-makers with a more accurate way to classify fall risk in elderly people.
Exergetic, Economic and Exergo-Environmental Analysis of Bottoming Power Cycles Operating with CO2-Based Binary Mixture
Authors: Haroon Muhammad , Sheikh Nadeem Ahmed , Ayub Abubakr , Tariq Rasikh , Sher Farooq , Baheta Aklilu Tesfamichael , Imran Muhammad
Published: September 2020

This study focused on investigating the bottoming power cycles operating with CO2-based binary mixture, taking into account exergetic, economic and exergo-environmental impact indices. The main intent is to assess the benefits of employing a CO2-based mixture working fluid in closed Brayton bottoming power cycles in comparison with pure CO2 working fluid. Firstly, selection criteria for the choice of suitable additive compound for CO2-based binary mixture is delineated and the composition of the binary mixture is decided based on required cycle minimum temperature. The decided CO2-C7H8 binary mixture with a 0.9 mole fraction of CO2 is analyzed in two cycle configurations: Simple regenerative cycle (SRC) and Partial heating cycle (PHC). Comparative analysis among two configurations with selected working fluid are carried out. Thermodynamic analyses at varying cycle pressure ratio shows that cycle with CO2-C7H8 mixture shows maximum power output and exergy efficiency at rather higher cycle pressure ratio compared to pure CO2 power cycles. PHC with CO2-C7H8 mixture shows 28.68% increment in exergy efficiency with the levelized cost of electricity (LCOE) 21.62% higher than pure CO2 PHC. Whereas, SRC with CO2-C7H8 mixture shows 25.17% increment in exergy efficiency with LCOE 57.14% higher than pure CO2 SRC. Besides showing lower economic value, cycles with a CO2-C7H8 mixture saves larger CO2 emissions and also shows greater exergo-environmental impact improvement and plant sustainability index.
Probabilistic Approach to Integrate Photovoltaic Generation into PEVs Charging Stations Considering Technical, Economic and Environmental Aspects
Authors: Branco Najmat Celene , Affonso Carolina M.
Published: September 2020

This paper investigates the integration of a photovoltaic system into plug-in electric vehicles charging stations in a university campus building located in Belem, Brazil, considering technical, economic, and environmental impacts in a probabilistic approach. Monte Carlo method is implemented to probabilistically estimate output variables, representing uncertainties from input data such as solar generation, vehicles demand and building load. Simulations are based on local irradiance data and electricity demand measurements collected by a local monitoring system installed in the building. The analysis comprehends a study time horizon of 10 years and evaluates transformer load and voltage level, carbon emissions avoided, and the financial feasibility of the project. Results show the connection of a PV system with penetration level of 15.6% can significantly reduce transformer overload occurrence by 69% and decrease overload duration time on average from 4 to 1 h at 10th year. PV system can reduce PEV CO2 emission by 97.4% on average compared with internal combustion engine vehicles. From a financial perspective, the project is feasible and economically attractive with a payback time that ranges from 6 to 8 years, being an attractive solution to the Amazon region to support a cleaner energy matrix.
Adequacy of Renewable Energy Mixes with Concentrated Solar Power and Photovoltaic in Morocco: Impact of Thermal Storage and Cost
Authors: Bouramdane Ayat-allah , Tantet Alexis , Drobinski Philippe
Published: September 2020

In this paper, we analyze the sensitivity of the optimal mixes to cost and variability associated with solar technologies and examine the role of Thermal Energy Storage (TES) combined to Concentrated Solar Power (CSP) together with time-space complementarity in reducing the adequacy risk—imposed by variable Renewable Energies (RE)—on the Moroccan electricity system. To do that, we model the optimal recommissioning of RE mixes including Photovoltaic (PV), wind energy and CSP without or with increasing levels of TES. Our objective is to maximize the RE production at a given cost, but also to limit the variance of the RE production stemming from meteorological fluctuations. This mean-variance analysis is a bi-objective optimization problem that is implemented in the E4CLIM modeling platform—which allows us to use climate data to simulate hourly Capacity Factors (CFs) and demand profiles adjusted to observations. We adapt this software to Morocco and its four electrical zones for the year 2018, add new CSP and TES simulation modules, perform some load reduction diagnostics, and account for the different rental costs of the three RE technologies by adding a maximum-cost constraint. We find that the risk decreases with the addition of TES to CSP, the more so as storage is increased keeping the mean capacity factor fixed. On the other hand, due to the higher cost of CSP compared to PV and wind, the maximum-cost constraint prevents the increase of the RE penetration without reducing the share of CSP compared to PV and wind and letting the risk increase in return. Thus, if small level of risk and higher penetrations are targeted, investment must be increased to install more CSP with TES. We also show that regional diversification is key to reduce the risk and that technological diversification is relevant when installing both PV and CSP without storage, but less so as the surplus of energy available for TES is increased and the CSP profiles flatten. Finally, we find that, thanks to TES, CSP is more suited than PV and wind to meet peak loads. This can be measured by the capacity credit, but not by the variance-based risk, suggesting that the latter is only a crude representation of the adequacy risk.
Trunk Flexion Monitoring among Warehouse Workers Using a Single Inertial Sensor and the Influence of Different Sampling Durations
Authors: Porta Micaela , Pau Massimiliano , Orrù Pier Francesco , Nussbaum Maury A.
Published: September 2020

Trunk flexion represents a risk factor for the onset of low-back disorders, yet limited quantitative data exist regarding flexion exposures in actual working conditions. In this study, we evaluated the potential of using a single inertial measurement unit (IMU) to classify trunk flexion, in terms of amplitude, frequency, and duration, and assessed the influence of alternative time durations on exposure results. Twelve warehouse workers were monitored during two hours of an actual shift while wearing a single IMU on their low back. Trunk flexion data were reduced using exposure variation analysis integrated with recommended exposure thresholds. Workers spent 5.1% of their working time with trunk flexion of 30–60° and 2.3% with flexion of 60–90°. Depending on the level of acceptable error, relatively shorter monitoring periods (up to 50 min) might be sufficient to characterize trunk flexion exposures. Future work is needed, however, to determine if these results generalize to other postural exposures and tasks.
Evaluation of the Lower Trapezius Muscle Using Ultrasound Panoramic View (a Novel Approach): An Intra- and Inter-Rater Reliability Study
Authors: Fernández-Carnero Samuel , Garrido-Marín Alejandro , Achalandabaso-Ochoa Alexander , Ferragut-Garcías Alejandro , Fernández-Matías Rubén , Pecos-Martín Daniel , Gallego-Izquierdo Tomás
Published: September 2020

The panoramic view ultrasound remains uncommon in clinical practice, probably because of its difficulty, high-cost, and lack of research. Morphological changes in muscles have been demonstrated to be related to symptomatology and provide data of interest for clinical assessment. Thus, the aim of this study was to evaluate the measurement reliability of the length of the lower trapezius muscle with the panoramic view ultrasound using a novel tool, SIG_VIP®. Twenty healthy volunteers were measured by two expert sonographers using the SIG_VIP® tool with a novel approach. Statistical analyses were performed with the R software. The intraclass correlation coefficient (ICC), standard error of measurement (SEM), minimal detectable change (MDC), and Bland-Altman plots were calculated. All the results indicated good intra-rater reliability (ICC3,1, 0.92 to 0.96; SEM, 0.59 to 0.85; MDC, 1.64 to 2.35) and inter-rater reliability (ICC3,2, 0.84 to 0.89; SEM, 1.22 to 1.53; MDC, 3.39 to 4.25). The novel system used with the described methodology can reliably measure the length of the inferior fibers of the trapezius muscle. Further research must be conducted to evaluate the reliability in patients and how pathology is related to the length of the lower trapezius muscle.
Taste and Health Information on Fast Food Menus to Encourage Young Adults to Choose Healthy Food Products: An Experimental Study
Authors: Folkvord Frans , van der Zanden Maud , Pabian Sara
Published: September 2020

Currently, a great number of people have an unhealthy dietary intake, leading to chronic diseases. Despite the high prevalence of obesity and people being overweight, only a few strategies to promote healthier food products have been proven effective. Therefore, the objective of this study was to test the effect of the presence of health information and its integration into a fast food menu context on young adults’ healthy food choices. An experimental between-subjects design consisting of three conditions—subtle, explicit, and no health information—was conducted among 142 participants aged 18 to 24 (Mage: 21.49, SD = 1.77). The results showed that when health information about healthy products was provided, the level of integration of the information into the menu context had an effect. More specifically, participants exposed to explicit health information about healthy products provided on the fast food menu were more likely to choose a healthy food product compared to participants exposed to subtle integrated health information. No interaction effect for moderating factors was found. In line with the healthy food promotion model, the findings suggest that the provision of explicit health information on healthy products stimulates healthy food choices in a fast food environment.
Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer
Authors: Cotrina Ellen Y. , Oliveira Ângela , Leite José Pedro , Llop Jordi , Gales Luis , Quintana Jordi , Cardoso Isabel , Arsequell Gemma
Published: September 2020

Transthyretin (TTR) is a homotetrameric protein involved in human amyloidosis, including familial amyloid polyneuropathy (FAP). Discovering small-molecule stabilizers of the TTR tetramer is a therapeutic strategy for these diseases. Tafamidis, the only approved drug for FAP treatment, is not effective for all patients. Herein, we discovered that benzbromarone (BBM), a uricosuric drug, is an effective TTR stabilizer and inhibitor against TTR amyloid fibril formation. BBM rendered TTR more resistant to urea denaturation, similarly to iododiflunisal (IDIF), a very potent TTR stabilizer. BBM competes with thyroxine for binding in the TTR central channel, with an IC50 similar to IDIF and tafamidis. Results obtained by isothermal titration calorimetry (ITC) demonstrated that BBM binds TTR with an affinity similar to IDIF, tolcapone and tafamidis, confirming BBM as a potent binder of TTR. The crystal structure of the BBM-TTR complex shows two molecules binding deeply in the thyroxine binding channel, forming strong intermonomer hydrogen bonds and increasing the stability of the TTR tetramer. Finally, kinetic analysis of the ability of BBM to inhibit TTR fibrillogenesis at acidic pH and comparison with other stabilizers revealed that benzbromarone is a potent inhibitor of TTR amyloidogenesis, adding a new interesting scaffold for drug design of TTR stabilizers.
An Investigation of Fibulin-2 in Hypertrophic Cardiomyopathy
Authors: Ibrahim Ayman M. , Roshdy Mohamed , Elshorbagy Sara , Hosny Mohammed , Halawa Sarah , Yehia Dina , Elfawy Hasnaa A. , Eldessouki Ahmed , Mohamed Faisal , Ellithy Amany , Abdelfattah Mohamed , Elsawy Amr , Elkhatib Mohamed , Allouba Mona , Elguindy Ahmed , Aguib Yasmine , Yacoub Magdi
Published: September 2020

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart muscle disease, with a prevalence of at least 1 in 500 in the general population. The disease is pleiotropic and is characterized by an increased stiffness of the myocardium, partly due to changes in the extracellular matrix (ECM), with elevated levels of interstitial fibrosis. Myocardial fibrosis is linked to impaired diastolic function and possibly phenotypic heterogeneity of HCM. The ECM consists of a very large number of proteins, which actively interact with each other as well as with myocardial cells. The role of other multiple components of the ECM in HCM has not been defined. Fibulin-2 is a glycoprotein component of the ECM, which plays an important role during embryogenesis of the heart; however, its role in adult myocardium has not been adequately studied. We here describe, for the first time, abnormal expression of fibulin-2 in the myocardium in patients with HCM as compared to normal controls. This abnormal expression was localized in the cytoplasm of myocardial cells and in the interstitial fibroblasts. In addition, fibulin-2 levels, measured by ELISA, were significantly elevated in the serum of patients with HCM as compared to normal controls.
Cross-Talk between P2X and NMDA Receptors
Authors: Rodriguez Larry , Yi Catherine , Chu Cameron , Duriez Quentin , Watanabe Sharyse , Ryu Megan , Reyes Brandon , Asatryan Liana , Boué-Grabot Eric , Davies Daryl
Published: September 2020

Purinergic P2X receptors (P2X) are ATP-gated ion channels widely expressed in the CNS. While the direct contribution of P2X to synaptic transmission is uncertain, P2X reportedly affect N-methyl-D-aspartate receptor (NMDAR) activity, which has given rise to competing theories on the role of P2X in the modulation of synapses. However, P2X have also been shown to participate in receptor cross-talk: an interaction where one receptor (e.g., P2X2) directly influences the activity of another (e.g., nicotinic, 5-HT3 or GABA receptors). In this study, we tested for interactions between P2X2 or P2X4 and NMDARs. Using two-electrode voltage-clamp electrophysiology experiments in Xenopus laevis oocytes, we demonstrate that both P2X2 and P2X4 interact with NMDARs in an inhibited manner. When investigating the molecular domains responsible for this phenomenon, we found that the P2X2 c-terminus (CT) could interfere with both P2X2 and P2X4 interactions with NMDARs. We also report that 11 distal CT residues on the P2X4 facilitate the P2X4–NMDAR interaction, and that a peptide consisting of these P2X4 CT residues (11C) can disrupt the interaction between NMDARs and P2X2 or P2X4. Collectively, these results provide new evidence for the modulatory nature of P2X2 and P2X4, suggesting they might play a more nuanced role in the CNS.
Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States
Authors: Santoro Anna Maria , D’Urso Alessandro , Cunsolo Alessandra , Milardi Danilo , Purrello Roberto , Sbardella Diego , Tundo Grazia R. , Diana Donatella , Fattorusso Roberto , Dato Antonio Di , Paladino Antonella , Persico Marco , Coletta Massimo , Fattorusso Caterina
Published: September 2020

The present study provides new evidence that cationic porphyrins may be considered as tunable platforms to interfere with the structural “key code” present on the 20S proteasome α-rings and, by consequence, with its catalytic activity. Here, we describe the functional and conformational effects on the 20S proteasome induced by the cooperative binding of the tri-cationic 5-(phenyl)-10,15,20-(tri N-methyl-4-pyridyl) porphyrin (Tris-T4). Our integrated kinetic, NMR, and in silico analysis allowed us to disclose a complex effect on the 20S catalytic activity depending on substrate/porphyrin concentration. The analysis of the kinetic data shows that Tris-T4 shifts the relative populations of the multiple interconverting 20S proteasome conformations leading to an increase in substrate hydrolysis by an allosteric pathway. Based on our Tris-T4/h20S interaction model, Tris-T4 is able to affect gating dynamics and substrate hydrolysis by binding to an array of negatively charged and hydrophobic residues present on the protein surface involved in the 20S molecular activation by the regulatory proteins (RPs). Accordingly, despite the fact that Tris-T4 also binds to the α3ΔN mutant, allosteric modulation is not observed since the molecular mechanism connecting gate dynamics with substrate hydrolysis is impaired. We envisage that the dynamic view of the 20S conformational equilibria, activated through cooperative Tris-T4 binding, may work as a simplified model for a better understanding of the intricate network of 20S conformational/functional states that may be mobilized by exogenous ligands, paving the way for the development of a new generation of proteasome allosteric modulators.
High Mannose N-Glycans Promote Migration of Bone-Marrow-Derived Mesenchymal Stromal Cells
Authors: Alonso-Garcia Vivian , Chaboya Cutter , Li Qiongyu , Le Bryan , Congleton Timothy J. , Florez Jose , Tran Victoria , Liu Gang-Yu , Yao Wei , Lebrilla Carlito B. , Fierro Fernando A.
Published: September 2020

For hundreds of indications, mesenchymal stromal cells (MSCs) have not achieved the expected therapeutic efficacy due to an inability of the cells to reach target tissues. We show that inducing high mannose N-glycans either chemically, using the mannosidase I inhibitor Kifunensine, or genetically, using an shRNA to silence the expression of mannosidase I A1 (MAN1A1), strongly increases the motility of MSCs. We show that treatment of MSCs with Kifunensine increases cell migration toward bone fracture sites after percutaneous injection, and toward lungs after intravenous injection. Mechanistically, high mannose N-glycans reduce the contact area of cells with its substrate. Silencing MAN1A1 also makes cells softer, suggesting that an increase of high mannose N-glycoforms may change the physical properties of the cell membrane. To determine if treatment with Kifunensine is feasible for future clinical studies, we used mass spectrometry to analyze the N-glycan profile of MSCs over time and demonstrate that the effect of Kifunensine is both transitory and at the expense of specific N-glycoforms, including fucosylations. Finally, we also investigated the effect of Kifunensine on cell proliferation, differentiation, and the secretion profile of MSCs. Our results support the notion of inducing high mannose N-glycans in MSCs in order to enhance their migration potential.
Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age
Authors: Gagné-Ouellet Valérie , Breton Edith , Thibeault Kathrine , Fortin Carol-Ann , Desgagné Véronique , Girard Tremblay Élise , Cardenas Andres , Guérin Renée , Perron Patrice , Hivert Marie-France , Bouchard Luigi
Published: September 2020

The aim of this study was to identify placental DNA methylation (DNAm) variations associated with adiposity at 3 years of age. We quantified placental DNAm using the Infinium MethylationEPIC BeadChips. We assessed associations between DNAm at single-CpGs and skinfold thickness using robust linear regression models adjusted for gestational age, child’s sex, age at follow-up and cellular heterogeneity. We sought replication of DNAm association with child adiposity in an independent cohort. We quantified placental mRNA levels for annotated gene using qRT-PCR and tested for correlation with DNAm. Lower DNAm at cg22593959 and cg22436429 was associated with higher adiposity (β = −1.18, q = 0.002 and β = −0.82, q = 0.04). The cg22593959 is located in an intergenic region (chr7q31.3), whereas cg22436429 is within the TFAP2E gene (1p34.3). DNAm at cg22593959 and cg22436429 was correlated with mRNA levels at FAM3C (rs = −0.279, p = 0.005) and TFAP2E (rs = 0.216, p = 0.03). In an independent cohort, the association between placental DNAm at cg22593959 and childhood adiposity was of similar strength and direction (β = −3.8 ± 4.1, p = 0.36), yet non-significant. Four genomic regions were also associated with skinfold thickness within FMN1, MAGI2, SKAP2 and BMPR1B genes. We identified placental epigenetic variations associated with adiposity at 3 years of age suggesting that childhood fat accretion patterns might be established during fetal life.
Pedestrian Navigation System with Trinal-IMUs for Drastic Motions
Authors: Ding Yiming , Xiong Zhi , Li Wanling , Cao Zhiguo , Wang Zhengchun
Published: September 2020

The combination of biomechanics and inertial pedestrian navigation research provides a very promising approach for pedestrian positioning in environments where Global Positioning System (GPS) signal is unavailable. However, in practical applications such as fire rescue and indoor security, the inertial sensor-based pedestrian navigation system is facing various challenges, especially the step length estimation errors and heading drift in running and sprint. In this paper, a trinal-node, including two thigh-worn inertial measurement units (IMU) and one waist-worn IMU, based simultaneous localization and occupation grid mapping method is proposed. Specifically, the gait detection and segmentation are realized by the zero-crossing detection of the difference of thighs pitch angle. A piecewise function between the step length and the probability distribution of waist horizontal acceleration is established to achieve accurate step length estimation both in regular walking and drastic motions. In addition, the simultaneous localization and mapping method based on occupancy grids, which involves the historic trajectory to improve the pedestrian’s pose estimation is introduced. The experiments show that the proposed trinal-node pedestrian inertial odometer can identify and segment each gait cycle in the walking, running, and sprint. The average step length estimation error is no more than 3.58% of the total travel distance in the motion speed from 1.23 m/s to 3.92 m/s. In combination with the proposed simultaneous localization and mapping method based on the occupancy grid, the localization error is less than 5 m in a single-story building of 2643.2 m2.
RaveGuard: A Noise Monitoring Platform Using Low-End Microphones and Machine Learning
Authors: Monti Lorenzo , Vincenzi Mattia , Mirri Silvia , Pau Giovanni , Salomoni Paola
Published: September 2020

Urban noise is one of the most serious and underestimated environmental problems. According to the World Health Organization, noise pollution from traffic and other human activities, negatively impact the population health and life quality. Monitoring noise usually requires the use of professional and expensive instruments, called phonometers, able to accurately measure sound pressure levels. In many cases, phonometers are human-operated; therefore, periodic fine-granularity city-wide measurements are expensive. Recent advances in the Internet of Things (IoT) offer a window of opportunities for low-cost autonomous sound pressure meters. Such devices and platforms could enable fine time–space noise measurements throughout a city. Unfortunately, low-cost sound pressure sensors are inaccurate when compared with phonometers, experiencing a high variability in the measurements. In this paper, we present RaveGuard, an unmanned noise monitoring platform that exploits artificial intelligence strategies to improve the accuracy of low-cost devices. RaveGuard was initially deployed together with a professional phonometer for over two months in downtown Bologna, Italy, with the aim of collecting a large amount of precise noise pollution samples. The resulting datasets have been instrumental in designing InspectNoise, a library that can be exploited by IoT platforms, without the need of expensive phonometers, but obtaining a similar precision. In particular, we have applied supervised learning algorithms (adequately trained with our datasets) to reduce the accuracy gap between the professional phonometer and an IoT platform equipped with low-end devices and sensors. Results show that RaveGuard, combined with the InspectNoise library, achieves a 2.24% relative error compared to professional instruments, thus enabling low-cost unmanned city-wide noise monitoring.
Robot Localization in Water Pipes Using Acoustic Signals and Pose Graph Optimization
Authors: Worley Rob , Ma Ke , Sailor Gavin , Schirru Michele M. , Dwyer-Joyce Rob , Boxall Joby , Dodd Tony , Collins Richard , Anderson Sean
Published: September 2020

One of the most fundamental tasks for robots inspecting water distribution pipes is localization, which allows for autonomous navigation, for faults to be communicated, and for interventions to be instigated. Pose-graph optimization using spatially varying information is used to enable localization within a feature-sparse length of pipe. We present a novel method for improving estimation of a robot’s trajectory using the measured acoustic field, which is applicable to other measurements such as magnetic field sensing. Experimental results show that the use of acoustic information in pose-graph optimization reduces errors by 39% compared to the use of typical pose-graph optimization using landmark features only. High location accuracy is essential to efficiently and effectively target investment to maximise the use of our aging pipe infrastructure.
ASURANSI SYARIAH DI INDONESIA HUKUM PROSPEK DAN TANTANGAN
Authors: Suparmin Asyari
Published: September 2020

Kehadiran asuransi syariah di Indonesia melengkapi hadirnya bank syariah yang lebih dulu di resmikan oleh Presiden Suharto yakni bank Muamalat Indonesia. Keberadaan asuransi syariah sangat penting karena keberadaaa dan dan asuransi saling  melengkapi dan membutuhkan. Sementara ummmat membutuhkan kepastian halal inilah yang mendasari mengapa asuransi syariah di pelukan.  Apa hokum asuransi, bagaimana perbedaan dengan produk konvensional, bagaimana prspek di  Indonesia serta apa tantangan yang di hadapi. Beberapa hal ini yang akan di bahas dalam tulisan ini
Methode diskriptif kwalitatif di pilih untuk menggambarkan kondisi asuransi syariah di Indonesia.  Pembahasan sangat di dipengruhi oleh pengalaman lapangan lebih drai dua puluh tahun.
Berbagai dukungan sangat di perlukan demi pengembangan asuransi syariah d Indonesia,  Sinergi antara   Ulama, Umara pemerintah dalam bentuk regulasi   serta dunia kampus sebagai kancah pendidikan.
ZAKAT PROFESI DAN ZAKAT SAHAM PERUSAHAAN SOLUSI ANGGARAN PENDIDIKAN NASIONAL
Authors: Arif Khairan M
Published: September 2020

Tujuan dari penelitian dalam makalah ini disajikan secara ilmiah dan historis tentang fungsi zakat dalam mengatasi masalah sosial seperti masalah anggaran pendidikan muslim, pergantian zakat dapat menjadi solusi, selain anggaran pendidikan nasional APBN, apalagi Indonesia adalah yang terbesar negara muslim di dunia.
Metode penulisan makalah ini adalah dengan menggunakan Metode Historis deskriptif, yaitu studi literatur Islam tentang konsep dan penerapan zakat dalam Islam serta mengabaikan pengalaman Negara-negara Islam di dunia dalam praktik keagamaan yang wajib untuk pendidikan anggaran.
ANALISA PENGEMBANGAN MIKRO EKONOMI SYARIAH BERBASIS PEMBERDAYAAN PEREMPUAN DAN RUMAH TANGGA
Authors: Munajah Neneng , Lubis Zulkarnain
Published: September 2020

Terjadinya krisis moneter dari ekonomi yang menimpa Indonesia memberikan banyak pelajaran berharga, salahsatunya adalah dengan mempersiapkan pemberdayaan perempuan dan keluarga dalam hal sebagai masyarakat yang produktif dan berdaya secara ekonomi, sehingga menjadi suatu lapisan yang akan tangguh mandiri ketika terjadi gelombang krisis ekonomi dan keuangan baik sekala nasional maupun global.
Peradaban yang unggul adalah peradaban yang kuat dalam berbagai aspek kehidupan suatu masyarakat, bangsa dan negara . Dimana berbagai aspek – aspek kehidupan Ekonomi, Pendidikan,  Budaya, Kesejahteraan, Kesehatan,  Hukum dan Keadilan, Keamanan dan kekuatan angkatan bersenjata mencapai puncak kemandirian, kuat dan terdepan.
Bagaimana suatu masyarakat , bangsa dan negara bisa mencapai keunggulan berbagai aspek kehidupan tersebut di atas salah satu indikator yang menjadi fokus pembangunan dan pengembangan adalah mempersiapkan manusianya.
Salah satu cara mempersiapkan manusia masa depan adalah dengan memperhatikan secara fokus dan serius pada sisi pemberdayaan perempuan dan keluarga.
Dalam hal ini Kaum perempuan , Karena Perilaku Kaum Wanita bisa menjadi indikator atau tolak ukur Kemajuan, Peradaban Suatu bangsa
Kemudian bagaimana mewujudkan suatu bangsa itu Kuat, Maju. Beradab dan Unggul dalam dunia sekarang ini dengan kemandirian ekonomi Islam (Syariah) di sektor Mikro berbasis wanita dan keluarga
ZAKAT UANG ELEKTRONIK
Authors: Uyuni Badrah , Adnan Mohammad
Published: September 2020

Uang elektronik merupakan alat pembayaran yang diterbitkan atas dasar nilai uang yang disetor terlebih dahulu oleh pemegang kepada penerbit, kemudian nilai uang tersebut disimpan secara elektronik dalam suatu media uang elektronik yang digunakan sebagai alat pembayaran oleh pemegang kepada pedagang.
Uang elektronik tersebut dipersamakan dengan uang karena pada saat pemegang menggunakannya sebagai alat pembayaran kepada pedagang, bagi pedagang tersebut nilai uang elektronik berpindah dari media uang elektronik yang dimiliki oleh pemegang ke terminal penampungan nilai uang elektronik milik pedagang. Apapun satuan nilai dalam media uang elektronik tersebut, pada dasarnya berupa nilai uang yang pada waktunya akan ditukarkan kepada penerbit dalam bentuk uang tunai (cash).
Dengan dipersamakannya uang elektronik dengan uang, maka pertukaran antara nilai uang tunai (cash) dengan nilai uang elektronik merupakan pertukaran atau jual beli mata uang sejenis yang dalam literatur Fikih Muamalat dikenal dengan Al-Sharf. Disamping al-shorf terdapat akad-akad lain yang terkait dengan transaksi uang elektronik, diantaranya adalah : al-ijarah, dan wakalah.
GOVERNMENT CREDIT GUARANTEE (GCG) FOR THE IMPROVEMENT OF PEOPLE AT THE BOTTOM OF THE ECONOMIC PYRAMID
Authors: NA SUBKHAN
Published: September 2020

The main objective of this study is to measure the impact of Government Credit Guarantee (GCG) scheme on household poverty alleviation. This study employed a cross-sectional design with purposive random sampling method to examine whether participation in GCG programs improves the hardcore poor households quality of life. To analyze the impact of GCG scheme on household poverty reduction, this study uses logistic regression model. The findings confirmed that households participating in GCG programs tend to have higher probability in reducing their poverty condition compared with those who have no access to GCG programs. The reduction in household poverty can be described by the improvement in their monthly income, improvement in monthly food expenditures, and improvement in monthly non-food expenditure. Therefore, Indonesian Government should review, re-organize and improve the GCG programs and policies in order to increase the outreach and improve client's ability to receive higher amount of loan through GCG scheme.A. Introduction
IMPLEMENTASI ETIKA BISNIS ISLAM DALAM PERBANKAN SYARIAH
Authors: Annisa Rizki , Sylvia Husnul Khotimah , Zahra Nurafifah
Published: September 2020

Pangsa pasar perbankan syariah di Indonesia masih relatif kecil bila di bandingkandengan pangsa pasar konvensional namun perbankan syariah memiliki tingkatpertumbuhan tahunan yang cukup signifikan. Perkembangan pangsa pasar syariah inicuckup menggembirakan namun belum diikuti dengan penerapan prinsip etika bisnisislam yang yang maksimal. Pengungkapan informasi etis bank syaraih baik yang bersifatkuantitatif maupun kualitatif (aspek moral maupun material) adalah hal yang mutlak bagibank syariah sebab secara yuridis bank syariah memiliki tanggung jawab untukmenunjukan bahwa bank syariah telah benar-benar menerapkan prinsip etika bisnis islamdalam kegiatan oprasionalnya dan juga dalam memberikan panduan kepada para pihakpemangku kepentingan atau stakeholder (yang terdiri dari nasabah penabung, pemegangsaham, investor, obligasi, bank responden, regulator, pegawai perseroan, pemasok, danlingkungan masyarakat) dalam membuat keputusan-keputusan ekonomi dalam upayamewujudkan akuntabilitas publik