bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors and preventive strategies in oral cancer: a comprehensive review
Authors: Quintana Sánchez Luis Miguel , Fernández Queija Yivelin , Hernández Cuétara Lourdes
Published: January 2025

Introduction: Oral cancer was identified as a global health problem due to its high morbidity and mortality. This malignant neoplasm, originating in the oral mucosa, affected structures such as the lips, tongue and hard palate, with squamous cell carcinoma being the most prevalent, representing 90% of the cases. The main risk factors included tobacco and alcohol consumption, with a synergistic effect that facilitated carcinogenesis. Other elements, such as diets low in fruits and vegetables, exposure to radiation, immunosuppression and unfavorable socioeconomic conditions, also contributed significantly. Early detection of premalignant lesions, such as leukoplakias and erythroplasias, was crucial to prevent progression to advanced malignant stages.Development: The study highlighted that tobacco consumption generated thermal, chemical and systemic damage to the oral mucosa, while alcohol promoted desiccation and immunodeficiency, increasing the risk of oral cancer. In addition, a diet rich in fruits and vegetables offered a protective effect, while excessive consumption of red meat and spicy foods increased exposure to carcinogens. Factors such as the use of ill-fitting dentures, viral infections, especially HPV, and prolonged radiation were relevant. Diagnosis by TNM classification allowed determining prognosis and directing effective treatments.Conclusions: The article concluded that oral cancer control required a comprehensive approach based on prevention, education, early diagnosis and timely treatment. The active participation of stomatologists in early detection and education of the population was essential. The importance of implementing educational programs and strengthening primary care to reduce risk factors, improve survival rates and guarantee a better quality of life in vulnerable populations was emphasized
The Impact of Oral Cancer in Argentina: Analysis of Risk Factors and Health Responses in 2024
Authors: Hernández Bridon Nairobi
Published: January 2025

In the year 2024, oral cancer was highlighted as a significant public health problem in Argentina, reflecting global trends and country-specific challenges. Oral cancer, included within malignant neoplasms, was characterized by an abnormal growth of cells that affected the oral cavity and sometimes spread to other parts of the body through metastasis. The disease mainly affected men over 50 years of age, although an increase in cases linked to the human papillomavirus (HPV) was observed in younger people.The geographical distribution of oral cancer in Argentina revealed significant inequalities. Northern provinces, with lower levels of socioeconomic development and limited access to health services, had higher rates compared to metropolitan regions. Risk factors such as smoking, excessive alcohol consumption and poor diets contributed to this disparity. Although prevention and education campaigns were intensified, their reach was insufficient in some rural and peripheral areas.The impact of oral cancer was not only limited to physical health, but also affected patients' quality of life, imposing a considerable emotional and economic burden. The public health system faced difficulties in providing advanced treatments due to lack of resources and unequal access. However, government efforts to strengthen primary care, train professionals and promote HPV vaccination as a key preventive measure were highlighted.Despite the challenges, prevention and early diagnosis were identified as essential strategies to reduce the burden of oral cancer and improve health outcomes in the country
Integrasi Psikologi dan Spiritualitas Islam dalam Pendekatan Holistik Pemulihan Trauma
Authors: Syifa Syifa , Nurjannah Nurjannah
Published: January 2025

Trauma is a psychological condition that deeply affects emotions, thoughts, and behavior. This study examines RF, a 15-year-old teenager, who experienced trauma due to family conflict and bullying. The research aims to explore RF's trauma, its effects on daily life, and recovery strategies using a holistic approach integrating modern psychology and Islamic spirituality. The study employs a qualitative descriptive method with data collected through interviews, observation, and documentation. Thematic analysis was used to identify key patterns related to RF's trauma. RF's trauma resulted from family conflict and verbal bullying, leading to low self-esteem, social withdrawal, and unresolved emotional distress. A holistic intervention combining psychological therapies like Gestalt and CBT with spiritual practices such as dhikr and Qur'an recitation significantly improved RF’s emotional balance. This integration addressed both emotional and spiritual needs, promoting recovery. The study demonstrates that a holistic approach combining psychology and spirituality offers better outcomes than conventional therapy. This innovative model addresses psychological, spiritual, and social dimensions, making trauma recovery a pathway for personal growth. Future research can explore its application across diverse populations and integrate digital tools to enhance accessibility and impact. The findings underline the need for a balanced approach that supports both emotional healing and spiritual resilience, offering practical insights for similar interventions.
Protectores bucales deportivos en la odontología [Sports mouthguards in dentistry]
Authors: Veloz-Diaz Jhonatan Stalin , Rocha-Rodríguez Astrid Elizabeth
Published: January 2025

Objetivo: analizar los protectores bucales deportivos en su implementación en la odontología. Método: revisión sistemática en población de 15 articulos científicos. Resultados y Conclusión: Los protectores bucales representan una herramienta esencial en la prevención de lesiones orofaciales en deportes de contacto, ofreciendo beneficios significativos tanto en términos de protección como de funcionalidad. Sin embargo, su adopción generalizada enfrenta múltiples desafíos, como la falta de conciencia, la percepción de incomodidad y la resistencia de los atletas.
LANSEKAP LAPANGAN TENIS INDOOR BALIKPAPAN DARI PRESFEKTIF KONTUR, SIRKULASI DAN VISUAL
Authors: Mulia Devi Suheriah , Nuri Huda Ahyar , Shiddiqqy Almi
Published: January 2025

Kota Balikpapan tumbuh menjadi Kota Modern dengan kelengkapan infrastruktur dasar dan infrastruktur penunjang yang bermacam-macam. Kota dituntut untuk memberikan pelayanan infrastruktur yang berkelanjutan dalam aspek infrastruktur jalan, gedung, ruang terbuka hijau hingga infrastruktur transportasi. Pengelolaan yang berkelanjutan ditujukan agar fasilitas yang telah dibangun dapat diakses oleh semua lapisan masyarakat. Penelitian ini bertujuan untuk menganalisis kondisi eksisting lapangan Tenis Indoor Balikpapan dalam aspek Analisa tapak dalam arsitektur. Penelitian ini menggunakan paradigma penelitian kualitatif dengan presfektif kontur, sirkulasi dan visual. Penelitian ini menemukan bahwa Lapangan Tennis Indoor Balikpapan memiliki kekuatan dalam memaksimalkan perancangan akses sirkulasi, dan kontur, namun terdapat kelemahan pada aspek visual yaitu tapak tidak memiliki nilai positif visual dari luar dan dari dalam
Protective effects of a combination of salvia miltiorrhiza bunge and astragalus membranaceus bunge against concanavalin A-induced liver injury in rats: A biomechanical perspective
Authors: Guan Tong , Fan Jian , Guan Feng , Wang Yanhong
Published: January 2025

Immune liver injury is a special type of chronic liver disease caused by immune dysfunction in the body. Salvia Miltiorrhiza (Danshen) and Astragalus membranaceus (Huangqi) have shown a synergistic effect in treating liver diseases in clinical settings. Nevertheless, the ideal combination ratio, dosage, and underlying mechanism of action of them remain uncertain. This research aimed to explore the biomechanical and immunological mechanisms of the combined use of Danshen and Huangqi in the treatment of liver injury, Which points to the regulation of lymphocyte biomechanics. To induce liver injury in rats, we administered Concanavalin A (ConA) via the tail vein. By observing liver indicators, serum biochemical indicators and liver tissue pathological changes in rats, the optimal ratio and dosage of the combination of “Danshen-Huangqi” was determined. Flow cytometry was used to analyze T lymphocyte subsets in rat peripheral blood. ELISA was performed to measure serum cytokine levels. RT-PCR was conducted to quantify specific transcription factors in rat aged 6–8 weeks liver tissue. Immunohistochemistry was utilized to evaluate the expression of apoptosis-related genes in rat liver tissue. The findings demonstrated that “Danshen-Huangqi” exerts bidirectional regulation on T lymphocyte subsets., influencing their biomechanical properties, such as cell stiffness and migratory behavior. The combination modulates the secretion of Th1, Th2, Th17, and Treg cytokines and specific transcription factors, thus rectifying the imbalance of Th1/Th2 and Th17/Treg (P < 0.05) lymphocyte subsets, but also inhibits atypical apoptosis of liver lymphocytes by controlling the expression of apoptosis-related genes in the rat liver with liver injury through the death receptor pathway and mitochondrial pathway. The biomechanical interactions of herbal remedies is to have a full effect on the protein molecules of target cells. Thus, the combination of Danshen and Huangqi may be a promising drug pair in improving liver injury. Compared with existing treatment options, this study is more mild and can be applied more widely in different populations.
Le attrezzature scolastiche come fulcro per la sostenibilità
Authors: Cuntò Stefano
Published: January 2025

Con la finalità di promuovere riflessioni in grado di informare il lavoro di progettisti e amministratori nell’elaborazione di politiche e interventi mirati a valorizzare il ruolo della scuola come driver chiave per affrontare la necessaria transizione alla sostenibilità delle nostre città, il contributo esplora il ruolo fondamentale dello standard all’istruzione inteso come standard trasversale. Attraverso un’analisi multidisciplinare, e partendo dall’esperienza del “Laboratorio standard”, vengono esaminate le diverse dimensioni entro cui la scuola può contribuire al raggiungimento di obbiettivi locali e globali: come catalizzatore di servizi di prossimità, erogatore di servizi ecosistemici, luogo fisico del welfare urbano e potenziale promotore di welfare sharing e punto chiave per la promozione della mobilità sostenibile a partire dalla mobilità casa-scuola. Si evidenzia come le scuole possano fungere da nodi strategici per la costruzione di comunità inclusive e resilienti, esplorando alcune best practice che possano indirizzare nella costruzione di nuove visioni e strategie di governance dell’infrastruttura scolastica.
Tendenze di cambiamento interessanti per l’urbanistica
Authors: Moccia Francesco Domenico
Published: January 2025

L’evoluzione tecnologica e sociale negli Stati Uniti offre importanti spunti per l’urbanistica globale, inclusa quella italiana. Il cambiamento delle modalità di lavoro, con l’introduzione dello smart working, sta trasformando la gestione degli spazi residenziali e aziendali, con un impatto diretto sulla progettazione degli edifici e sulla distribuzione degli spazi nelle città. Anche l’uso crescente della bicicletta elettrica sta modificando la mobilità urbana, rendendo necessaria la creazione di nuovi spazi ciclabili e la riorganizzazione delle infrastrutture per garantire la sicurezza dei ciclisti. Inoltre, l’incremento delle migrazioni climatiche pone nuove sfide in termini di accoglienza e integrazione, richiedendo una progettazione urbana più inclusiva e capace di rispondere alle esigenze di una popolazione sempre più diversificata. La robotica, l’intelligenza artificiale e la ricerca sulla biodiversità, infine, offrono opportunità per integrare soluzioni innovative nella pianificazione urbana, favorendo la sostenibilità, l’efficienza energetica e il miglioramento della qualità della vita nelle città del futuro.
Dalla conservazione della natura al ripristino degli ecosistemi
Authors: Casali Alessandra , Di Stefano Cristian , Munafò Michele
Published: January 2025

L’Antropocene ha segnato una discontinuità nell’equilibrio ecologico terrestre, con impatti devastanti causati dalle attività umane, come l’inquinamento e la perdita di biodiversità. In risposta, l’Unione Europea ha adottato la Nature Restoration Law per il ripristino degli ecosistemi degradati, con obiettivi ambiziosi per il 2030, 2040 e 2050.
La legge mira a promuovere ecosistemi sani e resilienti, fondamentali per la sicurezza alimentare, il clima e la salute umana. In Italia, la Strategia nazionale per la biodiversità al 2030 guida il percorso verso un ripristino sostenibile, integrando la natura nelle politiche di sviluppo economico e territoriale
Il ruolo dell'urbanista. Una riflessione nel ventennale della creazione del corso di studi di Urbanistica e Pianificazione ad Alghero
Authors: Rizzi Paola
Published: January 2025

Il 10 gennaio 2024, in occasione dei venti anni dalla nascita della scuola di “Urbanistica e Pianificazione”, si è tenuto ad Alghero un seminario sullo stato dell’arte e sulle nuove prospettive per urbanisti e pianificatori. Molte università stanno rinnovando i curricula, includendo maggiormente il ruolo nell’amministrazione pubblica, nonostante la professione soffra ancora di una mancanza di riconoscimento adeguato. La giornata ha offerto un momento di riflessione e nuove prospettive, con interventi di esperti nazionali e internazionali. Si è discusso dell’evoluzione dei piani di studio, dell’inclusione sociale e ambientale, e dell’apertura verso il Mediterraneo e l’estero. La seconda sessione ha visto un confronto tra scuole italiane, europee e asiatiche, evidenziando la necessità di adattare i corsi di studio alle sfide contemporanee come il cambiamento climatico e le disparità sociali. La giornata si è conclusa con un dibattito sulle competenze professionali e la necessità di un’educazione integrata con la pratica.
Il ruolo dei Contratti di fiume nella costruzione di necessarie politiche dell’acqua
Authors: Berruti Gilda , Coppola Emanuela
Published: January 2025

L’acqua è una risorsa limitata che deve essere protetta e utilizzata in maniera sostenibile. Nel 2012 la Commissione europea ha presentato il piano per la salvaguardia delle risorse idriche per tutelare le acque pulite e ripristinare la qualità delle stesse all’interno dell’Unione (nonché a garantire il loro utilizzo sostenibile nel lungo termine). Nel 2016, i Contratti di fiume sono stati riconosciuti a livello legislativo “quali strumenti volontari di programmazione strategica e negoziata che perseguono la tutela, la corretta gestione delle risorse idriche e la valorizzazione dei territori fluviali, unitamente alla salvaguardia dal rischio idraulico, contribuendo allo sviluppo locale di tali aree” (art. 68-bis “Contratti di fiume” del Dlgs 152/2006). Territori fragili e sempre più vulnerabili ai cambiamenti climatici, i corsi d’acqua si trovano in situazioni critiche. È appurata, di fatti, una stretta correlazione fra l’intervento antropico sul corso d’acqua e nella gestione del bacino e le preoccupanti e brusche variazioni morfologiche registrate nei nostri corsi d’acqua (Cirf 2017).
Il contributo dei Contratti di fiume alle strategie di adattamento climatico e di sviluppo sostenibile
Authors: Bastiani Massimo
Published: January 2025

Le comunità locali, anche grazie all’impulso dato dalle direttive europee, stanno ritrovando un nuovo protagonismo nella territorializzazione delle politiche pubbliche. Affrontare temi di ordine globale come il cambiamento climatico o il rischio idrogeologico e più in generale il perseguire uno sviluppo sostenibile, richiedono la messa in campo di strumenti di governance e partecipazione innovativi che, come i Contratti di fiume, possano dare risposte ascendenti e rendere più resilienti gli assetti socio-territoriali.
Contratti di fiume come processi di campo
Authors: Serreli Silvia , Monno Valeria
Published: January 2025

Ciò che rende peculiare il Contratto di fiume è la sua finalità di ricongiungimento delle comunità locali all’acqua grazie ai processi di coproduzione di conoscenze e progetti di rigenerazione urbana e territoriale. Un ripensamento della sua governance come processo di campo introduce diverse rappresentazioni dell’acqua e differenti opportunità legate alla concezione di vulnerabilità relazionale.
Building Food Resilience Against Floods: A Systematic Review of Absorptive, Adaptive and Transformational Strategies
Authors: Handayani Naniek Utami , Ulkhaq M. Mujiya , Sari Diana Puspita , Mahachandra Manik , Salsabila Sheila Syifa
Published: January 2025

Food resilience in flood-prone areas is a growing concern due to the increasing frequency and severity of floods caused by climate change. Floods can damage agricultural systems, disrupt supply chains, and lead to food insecurity, especially in vulnerable regions, including developing countries. This study then aims to identify and evaluate strategies to enhance food resilience in flood-prone areas by synthesizing existing research into absorptive, adaptive, and transformational capacities. It also seeks to develop an integrated framework to address short- and long-term food security challenges. A systematic literature review (SLR) was conducted following the PRISMA framework. The Scopus database was used to identify 325 articles published between 2010 and 2024. After a rigorous screening and eligibility process, 38 studies were selected for thematic and scientometric analysis to identify trends, methodologies, and strategies. The findings highlight three key resilience capacities: absorptive, adaptive, and transformational. Absorptive capacity focuses on minimizing immediate impacts through water management and drainage infrastructure. Adaptive capacity emphasizes medium-term adjustments, including diversified crops, Climate-smart agriculture, and improved supply chains. Transformational capacity addresses long-term structural reforms, such as biotechnology applications and integrated farming systems. Combining these strategies offers a holistic approach to building sustainable food systems resilient to floods. Addressing food security in flood-prone areas requires a proactive, multi-dimensional approach that incorporates absorptive, adaptive, and transformational capacities. The integrated framework developed in this study provides insights for policymakers, researchers, and stakeholders to create sustainable and resilient food systems amid climate variability and flood risks.
GAMIFICATION IN LEARNING LANGUAGE: A CASE STUDY OF TEACHING LANGUAGE TO TOURISM STUDENTS
Authors:   Khoja Akhmet Yassawi International Kazakh-Turkish University, Zh. ABDIKHANOVA  , А. SHOQPAROV  ,   International University of Tourism and Hospitality, А. NURMANOVA  ,   Khoja Akhmet Yassawi International Kazakh-Turkish University
Published: January 2025

This article examines the impact of gamification and video games on the process of learning English among students studying in the field of tourism, in order to develop their language skills and increase motivation. The study was conducted at the International University of Tourism and Hospitality in Turkestan and was based on a mixed method, including questionnaires, observation and interviews with students and teachers. The study involved 15 first-year students who used the Quizlet platform for four weeks to learn new vocabulary. The motivation scale for language learning and the Quizlet questionnaire were used to assess their motivation and attitude to the gamified approach. According to the results of the pre-test and post-test surveys, as well as the t-test for paired samples, there were no statistically significant differences (p = 0.476) in the level of vocabulary proficiency, although there was a slight improvement. At the same time, observations and interviews have shown that gamification promotes active participation of students, positively affects their motivation and makes language learning more interactive and exciting. The teachers also noted an increase in student engagement and an improvement in the classroom atmosphere.
ASSESSMENT OF ROAD INFRASTRUCTURE AND ROADSIDE SERVICE AS FACTORS AFFECTING THE TOURIST ATTRACTIVENESS OF THE REGION (ON THE EXAMPLE OF PAVLODAR REGION)
Authors:   Toraighyrov university, JANARGALIYEVA М. , DAUYT ZH. ,   Toraighyrov university
Published: January 2025

Tourism industry is one of the fastest growing industries in the 21st century. In 2023, the share of travel and tourism industry in the world GDP will amount to 9.1%, which is 23.2% more than in 2022. The article deals with the issue of interrelation of road and roadside services with tourism, namely their influence on the tourist attractiveness of the region. The experience of foreign countries in improving these services with statistics was analyzed. The trends in the construction of transport systems were also considered, taking into account the component of sustainability and environmental friendliness, namely the introduction of advanced technologies such as soil stabilization methods, the use of nanopolymer admixture, the use of recycled and environmentally friendly materials, the introduction of smart sensors for monitoring the condition of roads, the integration of renewable energy sources. Further the situation with transportation systems and roadside services in our country was studied. In Kazakhstan there is an increase in the indicator of road quality. According to the information of the Ministry of Transport of the Republic of Kazakhstan, last year the share of roads of republican importance that meet the standards reached 92%. As for the development of roadside service, this issue in Kazakhstan is becoming increasingly important due to the increase in the flow of vehicles and the growing number of tourists. According to the instruction of the Head of State, by 2025 all roads will be provided with roadside services that comply with the National Standard. On the basis of this standard a standard map of roadside service location in Pavlodar region (Aksu, Ekibastuz, Bayanaulsky district) was developed.
OPPORTUNITIES FOR TEACHING ENGLISH TO STUDENTS OF THE TOURISM SPECIALTY USING FLIPPED CLASSROOM TECHNOLOGY
Authors:   L. N. Gumilyov Eurasian National University, NURMAGANBETKYZY Н. , ALMUKHAMBETOVA B. ,   International University of Tourism and Hospitality, ISKAKOV Т. ,   International University of Tourism and Hospitality
Published: January 2025

Currently, digital technologies have become the main component used in all spheres of society. The application of such scientific achievements in higher education is becoming one of the most relevant topics today. One of the educational methods based on modern digital achievements in the learning process is the Flipped Classroom technology. This technology can be used in teaching students at any level of education. The purpose of this article is to study and prove the effectiveness of using Flipped Classroom technology at the stage of teaching English to students studying in the educational field of Tourism. The research was conducted on the study of works written by world scientists in order to describe the features of the technology application, discuss and summarize the experience conducted by 1st year students of the International University of Tourism and Hospitality based on these theoretical aspects. The main idea of the article is to open up new opportunities for easy and effective teaching of English to students of the specialty Tourism by analyzing various experiments of scientists conducted so far. During the practice, in order to determine the practical effectiveness of technology in teaching English, students were divided into experimental and control groups. There has been significant progress in the ratio of the test of students' preliminary theoretical knowledge to the test results after practice and the level of their ability to speak English. Students' interest in the English language is also growing, and their inspiration is awakening. This, in turn, proved that Flipped Classroom technology is one of the most active learning methods based on digital capabilities. The value of the research work is expressed in the possibility of using Flipped Classroom technology as an innovative idea when conducting practical classes for students of the specialty Tourism based on the results of this study.
EFFECT OF CULTURE CONDITIONS ON BACTERIA-INDUCED CALCITE PRECIPITATION OF Bacillus subtilis QN7 STRAIN
Authors: Tran Trung Kien  , Nguyen Thi Phuong Thao  , Le Quynh Loan  , Tran Thi My Ngoc  , Vu Thi Tuyet Nhung  , Duong Thi Hong Dao  , Tran Quang Vinh  , Nguyen Hoang Dung
Published: January 2025

Nghiên cứu này nhằm thu lượng kết tủa calcium carbonate cao nhất dựa trên hoạt động của vi khuẩn cảm ứng sự hình thành kết tủa canxit (MICP). Cụ thể, để xác định điều kiện tối ưu nhằm thu lượng kết tủa cao nhất của chủng Bacillus subtilis QN7, thí nghiệm tiến hành thay đổi một số thông số bao gồm (1) mật độ vi khuẩn, (2) độ pH, (3) nhiệt độ nuôi cấy, (4) nồng độ urea, (5) nguồn calcium và (6) nồng độ calcium, từ đó xác định hoạt tính urease của chủng này. Kết quả cho thấy nguồn calcium hiệu quả nhất thu hàm lượng kết tủa cao là calcium clorua bổ sung 150 - 200 mM CaCl2 và 250 mM urea ở 40 oC, pH 8, hàm lượng kết tủa đạt 10,21 g/L, hoạt độ enzyme urease thu được là 703,86 U/L. Kết quả nghiên cứu bước đầu đã xác định được điều kiện tối ưu để chủng B. subtilis QN7 tạo kết tủa CaCO3 tốt nhất. Đây là tiền đề cho các nghiên cứu tiếp theo về tiềm năng ứng dụng chủng B. subtilis QN7 trong việc hàn gắn vết nứt, khả năng tự phục hồi và sản xuất xi măng sinh học trong điều kiện khí hậu và môi trường Việt Nam.
OPTIMIZING ALLOPHYCOCYANIN EXTRACTION FROM Chaetomorpha sp. ALGAE WITH ENZYME CELLULASE
Authors: Ngo Thi Cam Thuong  , Lam Nguyen Dan Khoa  , Do Thi Hue Tran  , Ho Xuan Quynh  , Luong Ngoc Han  , Hoang Thi Ngoc Nhon
Published: January 2025

Allophycocyanin (APC) là một loại protein mang sắc tố thuộc nhóm phycobiliprotein, được cấu tạo từ 2 tiểu đơn vị α và β, mang nhiều hoạt tính sinh học đặc trưng như tính huỳnh quang, hoạt tính kháng oxy hóa, kháng khuẩn, mốc... Nghiên cứu này được thực hiện để thu nhận APC từ rong Chaetomorpha sp. có sự hỗ trợ của enzyme cellulase bằng phương pháp thực nghiệm. Các yếu tố ảnh hưởng được khảo sát gồm: thời gian xử lý enzyme (30; 60; 90; 120; 180 phút), tỷ lệ nguyên liệu/dung môi khảo sát (1:10; 1:15; 1:20; 1:25; 1:30, w/v) và tỉ lệ enzyme/cơ chất khảo sát (1%; 2%; 3%; 4%; 5%). Phương pháp bề mặt đáp ứng (RMS) được sử dụng để tối ưu hóa các yếu tố ảnh hưởng đến quá trình trích ly. Kết quả thu được cho thấy khi tỉ lệ enzyme/cơ chất 3,21%; tỉ lệ nguyên liệu/dung môi là 1:20,89 w/v; thời gian trích ly 102,68 phút thu được hàm lượng APC ở điều kiện tối ưu đạt 0,27 mg/mL.
OPTIMIZATION OF TRITERPENES EXTRACTION FROM Ganoderma lucidum BY SUPERCRITICAL CARBON DIOXIDE
Authors: Tran Duc Duy  , Nguyen Tran Bao Chau
Published: January 2025

Nấm Linh Chi (Ganoderma lucidum) là một loài nấm thường được tìm thấy ở các nước Á Đông. Hiện nay, Linh Chi được dùng khắp nơi trên thế giới như một loại thuốc bổ hay một loại thực phẩm chức năng. Hoạt tính sinh học của nấm Linh Chi chủ yếu do các polysaccharide, peptidoglycan và triterpene mang lại. Thông thường, nước là dung môi được sử dụng để thu dịch Linh Chi. Tuy nhiên, phương pháp truyền thống này chỉ thu được các hoạt chất phân cực chẳng hạn như các polysacharide. Trong những năm gần đầy, kỹ thuật trích ly bằng dung môi siêu tới hạn được đề cập trong nhiều nghiên cứu, nhằm tăng hiệu quả thu hồi chất chiết đồng thời bảo toàn chất lượng các hợp chất có hoạt tính sinh học. Trong nghiên cứu này chúng tôi sử dụng CO2 siêu tới hạn để trích ly các hoạt chất từ nấm Linh Chi. Kết quả cho thấy, điều kiện tối ưu để trích ly với CO2 siêu tới hạn là nồng độ đồng dung môi ethanol 14% (w/w), lưu lượng dòng 14g/phút, thời gian xử lý 120 phút, nhiệt độ xử lý 59 oC và áp suất xử lý 153 bar. Ở điều kiện này, hiệu suất thu hồi triterpen và chất khô hòa tan lần lượt là 88.9% và 39.2%. So với phương pháp xử lý nấm Linh Chi dưới sự hỗ trợ của enzyme, phương pháp CO2 siêu tới hạn cho hiệu suất thu hồi triterpen và độ tinh sạch của sản phẩm cao hơn nhưng hiệu suất trích ly chất khô hòa tan thì không bằng phương pháp enzyme.
Predicting Cardiovascular Disease by Integrating the Dataset and DNN with Asynchronous Learning Technique
Authors: RAMESH BABU PITTALA  , Dr. Narendra B Mustare  , Kavitha G L  , Dr. A. Azhagu Jaisudhan Pazhani  , Dr Subba Rao Polamuri
Published: January 2025

Predicting cardiovascular illness via the integration of datasets and deep neural networks using an asynchronous learning methodology. Healthcare experts see the prediction of cardiac disease as a critical endeavour, while deep learning has shown considerable potential in accomplishing this objective. This research study presents a unique methodology termed the Asynchronous Federated Deep Learning Approach aimed at Cardiac Predictions (AFLCP), which integrates a heart disease dataset along with DNN through an asynchronous learning strategy. Suggested method utilises an asynchronous parameter update mechanism for deep neural networks and integrates a temporally weighted aggregate strategy to improve the convergence and accuracy of core model. The efficacy of the proposed AFLCP technique is assessed using two datasets across several DNN architectures, revealing that proposed AFLCP method surpasses baseline technique for communication expenses and model correctness.
Error Analysis in First-Year AB English Language Students’ Written Compositions
Authors: Garcia Michael , Amado Ruby
Published: January 2025

This study addresses the gap in understanding grammatical errors in English compositions among first-year ABEL (Bachelor of Arts in English Language) students at Pangasinan State University – Urdaneta City Campus during the academic year 2022-2023. The objectives include identifying the demographic profile of the students regarding their mother tongue and attitudes toward English grammar and writing, analyzing the most common grammatical errors using the Surface Strategy Taxonomy, exploring the relationship between errors and profile variables, and determining the causes of these errors. A mixed-method research design was employed, with data collected through a researcher-made questionnaire administered via Google Forms and face-to-face writing compositions about students' experiences during the pandemic. Findings revealed that the majority of respondents (60%) spoke Tagalog as their mother tongue, demonstrating a highly favorable attitude toward English grammar learning (mean score of 3.40) and a moderately favorable attitude toward English writing (mean score of 3.00). The most frequent grammatical error identified was misformation (40.69%), followed by omission (32.19%), addition (25.86%), and misordering (1.27%). Results showed no significant relationship between the errors and demographic profile variables. Semi-structured interviews with ten participants confirmed interlingual interference as a significant factor influencing errors, highlighting challenges transitioning from the student’s mother tongue to English. The findings emphasize the need for targeted grammar instruction to enhance independent learning and student outcomes. Practical recommendations include integrating interactive grammar activities, personalized feedback mechanisms, and mother tongue awareness strategies into ESL instruction to address persistent error patterns effectively.
Valerianella carinata Loisel. a Bükkben, és néhány kiegészítés a Matricum flórájához
Authors: Süveges Kristóf
Published: January 2025

In this paper, I present new occurrences of 22 vascular plants species from the North Hungarian Mountains, mainly from mountain foothills and low-lying areas. Most of the data come from the geogra­phical sub-regions of the Southern Mátra and Litke-Etesi hills. In the Southern Mátra no occurrence of Lathyrus aphaca was previously known, and hardly any data or localities are known for Carex supina, Draba muralis, Geranium rotundifolium, Valerianella dentata, V. rimosa. A new occurrence of Melilotus dentatus from the Litke-Etesi hills is also a significant data in botanical-geographical terms. From the Bükk Mountains, I report the occurrence of Valerianella carinata; no previous data of this species was known from the mountains. Centaurium uliginosum subsp. littorale and Gnaphalium luteoalbum were found in a sand pit in the Gödöllő hills.
New record of Leptophyes discoidalis (Frivaldszky, 1867) : Transylvanian flower bush-cricket (Orthoptera, Tettigonnidae: Pheneropterinae) in Pannonicum (Debrecen, Hungary)
Authors: Zilay Tamás , Rácz István András
Published: January 2025

This article presents a new record of the Eastern and Central European bush-cricket Leptophyes discoidalis (Frivaldszky, 1868) (Tettigoniidae: Phaneropterinae) from the Pannonian Plain: in Nagyerdő near Debrecen (Hungary) which is a protected area. The new occurrence has specific ecological parameters.
Wilson’s bird of paradise (Diphyllodes respublica) data from Batanta (Indonesia: West Papua, Raja Ampat)
Authors: Horváth Róbert , Kovács Tibor , Juhász Péter
Published: January 2025

Our research on Diphyllodes respublica in Batanta began in 2009. Over 220 field days inclu­ding more than 60 nights and early mornings spent in the field, we conducted surveys in the valleys of 21 waterways and additional areas. The species’ presence was recorded based on visual observations (presence of males, females and display courts) and acoustic cues, specifically the characteristic calls of males. We found the species at six locations: one at 45 meters, two between 90–120 meters, and three others between 320–420 meters above sea level. The site at 45 meters is of particular interest, because the species has previously been reported only from elevations between 100–1200 meters. We observed aggregate and synchronized courtship displays of males on two occasions. Based on our observations, display courts appear to be inherited and maintained for decades. The display court found at 45 meters in the valley of the Waibin River is at the lowest elevation observed to date. Although we rarely visited areas above 400 meters, based on the six habitat patches we found over the 15 years, we believe the species is not common on Batanta. Two-thirds of its known habitats are located in protected areas. Based on our findings, we recommend the protection of the entire island, the prohibition of deforestation, and the uplisting of Diphyllodes respublica from “Near Threatened” to the “Vulnerable” IUCN category.
Recurrent Axillary Hidradenitis Suppurativa in a Patient with Uncontrolled Type 2 Diabetes Mellitus
Authors: Kranthi Swaroopa Velisetti  , Grace Hadassah Busi  , Annie Christine Nadipalli  , Parash Niroula  , Dileep Varma Inampudi
Published: January 2025

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition that predominantly affects areas rich in apocrine glands. This case report presents a 43-year-old male patient with a two-year history of recurrent axillary HS complicated by uncontrolled type 2 diabetes mellitus. The patient initially developed small nodular lesions measuring 0.53 cm in both axillae, which progressively worsened into extensive lesions with pain and purulent discharge. His medical history was significant for a 15-year history of diabetes mellitus managed with metformin and glimepiride, past smoking history of 25 years, and alcohol consumption. Laboratory findings revealed elevated inflammatory markers, uncontrolled blood glucose levels, and mild anemia. The patient underwent surgical excision of the lesions, followed by reconstruction using a thoracodorsal artery perforator (TDAP) fasciocutaneous flap for wound coverage. Postoperative management included a comprehensive approach with broad-spectrum antibiotics (amoxicillin-clavulanate, doxycycline, and metronidazole) and intensive insulin therapy. The patient showed significant improvement during the four-week hospital stay, with successful wound healing and better glycemic control. The case shows the potential impact of metabolic disorders on the progression and management of HS.
Globalizing education: impacts on policies, systems, access, and outcomes across nations
Authors: Angana Meriam , Orge Linrose , Galigao Regina
Published: January 2025

This study aimed to analyze the impact of globalization on educational policies, educational system, access to education, and educational outcomes across different countries. This examined how the impact of globalization in many countries is, highlighting how large these sub-variables are for promoting positive effects in education. This research used a data mining method with a qualitative analysis approach to analyze the impact of globalization in education. Data mining methods involving qualitative analysis focus on extracting meaningful patterns and insights from qualitative data. This approach emphasizes understanding the underlying themes and contexts within the data, utilizing techniques like thematic analysis, grounded theory, and content analysis. The results showed that globalization in education has led to policy and system improvements, including global standards, extension of cycles, and vocational integration. However, inequities persist in low-income countries due to resource and socioeconomic limitations. Combining global norms with local relevance remains a challenge.
Az angol irodalom története. III–IV: Az 1640-es évektől az 1830-as évekig. Első és második rész
Authors: Barcsák János V.
Published: January 2025

Volume 4 of the Hungarian History of English Literature is in fact the second part of volume 3. These volumes together cover the literature of the “long 18th century”, the period between the 1640s and the 1830s, and while volume 3 – after the general introduction – discusses the poetry of the era, volume 4 focuses on drama and prose. Accordingly, volume 4 is divided into two sections, one on drama and one on prose. Each section begins with a useful introduction (by Veronika Schandl and Gabriella Hartvig, respectively), which gives an overview of the issues discussed in more detail in subsequent chapters.
The Effectiveness Of The Distribution Of Zakat Funds In The Bali Makmur Program In Improving Mustahik Welfare In Baznas Bali Province
Authors: Rachid Gunawan Wibisono  , R. Agrosamdhyo2, Kurniawati
Published: January 2025

Over time, BAZNAS has become one of the important institutions in the management of zakat in Indonesia, by increasing efficiency, transparency, and effectiveness in managing zakat, as well as distributing it to those in need. Therefore, the effectiveness of the distribution of zakat funds in the Bali Makmur Program at BAZNAS Bali Province plays an important role. This study aims to understand the effectiveness of the distribution of zakat funds in the Bali Makmur Program in improving the welfare of mustahik in BAZNAS Bali Province. The focus of this research; 1) What is the form of distribution of zakat funds in the Bali Makmur Program at BAZNAS Bali Province?, 2) What is the effectiveness of the distribution of zakat funds in the Bali Makmur Program in improving the welfare of mustahik in BAZNAS Bali Province? and 3) What are the obstacles in the distribution of zakat funds in the Bali Makmur Program at BAZNAS Bali Province? The objectives of this study are; 1) To find out the form of distribution of zakat funds in the Bali Makmur Program.2) To identify the effectiveness of the Bali Makmur Program in improving the welfare of mustahik in the city of Denpasar Bali and 3) To find out the obstacles faced in the distribution of zakat funds in the Bali Makmur Program. The research method to be used is qualitative descriptive, with data collection techniques through observation, interviews, and documentation, as well as data validity techniques through the triangulation method. Determination of informants by purposive sampling technique. The results of the research will be described in a descriptive manner.
Investigating the Effects of Aquatic Pollutants on Human Health
Authors: Ibragimov Sunnatulla , Mavlyanova Ravza , Burieva Nargiza , Abdusatorov Sherzod , Mengliboev Akmal , Nazirov Bakhtiyor , Norbotaev Islambek , Zokirov Kurbonalijon
Published: January 2025

Water is the most essential component that sustains us and serves as the basis for life, which allows us to live. Clean, clear water must be available to everybody. Numerous water contaminants arise as a result of both natural and man-made sources of contamination. These water pollutants need to be eliminated in order to protect individuals from various diseases and maintain their health. However, access to the world's water assets changes incredibly among nations and districts. Environmental change and water contamination fuel the generally desperate state of water shortage. The World Wellbeing Association assesses that 2 million individuals universally don't approach clean water. Also, it is assessed that 3.4 million individuals pass on every year from water deficiencies or harming, with the vast majority of these passings happening in agricultural nations. Every year, millions of people get water-borne illnesses from drinking contaminated water or from eating fruits and vegetables that were grown in contaminated water. Water pollution in India has several negative impacts on human health, including harm to both people and marine life. Both adults and children in India are negatively impacted by water pollution in a variety of ways.
Evaluating the effectiveness of eco-labeling schemes in promoting sustainable fishing practices
Authors: Upadhyay Naveen , Rana Naveen Singh , Hooda Ramesh Chander , Desai Tripti
Published: January 2025

Fish are an important ecological component that aids in the distribution of marine production among terrestrial creatures. Phytoplankton contributes 45–50 Gt C year-1 to global net primary production, which is half of global net primary productivity. In contrast, 1.9 Gt C year-1 of net primary production is contributed by the world's coastal vegetation. Ocean life is sustained by this enormous productivity, which is distributed among higher order creatures through energy transfer and trophic interactions. Fish store a large amount of this energy, which humans then eat. Fish are so crucial to the cycling of nutrients and energy between aquatic and terrestrial ecosystems. To guarantee a sustainable marine fishery, it is crucial to comprehend the structure of marine ecosystems and the energy transfer at the trophic level. Initiatives to encourage sustainably managed fisheries and draw attention to their products are known as eco-labelling. The goal of eco-labelling product claims is to meet the public's increasing need for environmentally friendly goods. Life-cycle assessments are typically used by eco-labels to ascertain a product's environmental impact "from cradle to grave." The underlying premise of all eco-labelling programs is that consumers' purchase decisions are influenced by factors other than price and required quality and health criteria. Instead, customers' considerations of product features can be related to both economic and social goals as well as ecological and environmental goals
Meta-Learning and Bi-Tier Selection Based Classification Algorithm Recommendation
Authors: Guo Wei , Minawaer Mutila , Ren Zhizhong , Hao Siqi
Published: January 2025

Aiming at the problem of how to select the best algorithm for a given classification
problem, a meta-learning and Bi-Tier selection based classifier recommendation (MLBCR) is
proposed. Firstly, a set of meta-features is extracted to characterize the classification dataset by
combining meta-learning. Secondly, a comprehensive evaluation index is proposed to
comprehensively evaluate the performance of 11 candidate classification algorithms on each
classification dataset, and the algorithm with the best evaluation is defined as the best algorithm for
the dataset. Then, the meta-feature vector corresponding to the training dataset and the best
algorithm are stored in the MySQL database in the form of tuples. Finally, the dynamic interval is set
according to the similarity between the features, the similar data sets of the new data set are
identified, the algorithms corresponding to the similar data sets are obtained from the database, and
the algorithm with the best performance is selected and recommended to the new classification
dataset. The experimental results show that the recommendation accuracy of the proposed
algorithm recommendation model and the classification accuracy of the recommended best
algorithm are improved by 2.42% and 1.18% respectively, which provides a more applicable
solution for solving practical classification problems
Experimental Analysis and Construction of Measurement Model for Torque Calibration Device in Variable Temperature Environment
Authors: Guo Feng , Lin Jiejun , Li Tao , Jiang Weijie
Published: January 2025

The article introduces the design structure and principle of a torque calibration device in a
5kNm variable temperature environment. By constructing a measurement model, it quantitatively
analyzes the measurement uncertainty of the device and conducts calibration tests on standard
torque sensors. The results indicate that the designed device can provide theoretical foundations
and a basis for the traceability of torque sensors in variable temperature environments
Microwave Vacuum Puffing Technology for Food Products: a Review
Authors: Chang Zhi , Liu Tong , Wang Ke , Mao Chao
Published: January 2025

Puffed food is popular because of its loose structure, crisp taste, and broad market
prospects. The traditional frying puffing method has been gradually abandoned due to health
problems such as cardiovascular disease, hypertension, etc., and replaced by low-temperature and
healthy processing methods. As a new puffing technology, microwave vacuum puffing (MVP)
combines the instantaneousness of microwave heating and the low temperature of vacuum drying, which can better retain the color, aroma, taste, and nutritional components of food. This paper
introduces the principle and processing characteristics of MVP. The process parameters, product
quality, puffing kinetics, mass transfer, heat transfer kinetics, and processing equipment were
reviewed. Finally, the future development and trend of this technology were discussed
Application of Virtual Simulation in Education: Current Status, Hot Spots and Trends
Authors: Dai Xu , Fu Xinjian , Zuo Jiayu , Shi Lianshuan
Published: January 2025

The use of virtual simulation in teaching and learning has become increasingly
widespread. However, there is still a lack of systematic reviews in the field of virtual simulation
education. Using CiteSpace visual analysis software and bibliometric methods, we analyzed 223
articles from the Web of Science core dataset to examine the current status, key areas, and trends
in virtual simulation education research. Additionally, we identified existing gaps and proposed
future research directions. Our findings indicate that virtual simulation technology is most commonly
integrated with medical education. China leads in the number of annual publications, with a
significantly higher research output than other countries. However, research collaboration between
countries remains limited. Regarding research themes, the integration of artificial intelligence with
virtual reality in intelligent virtual simulation is expected to expand further. Researchers should
enhance international collaboration, introduce emerging technologies such as generative artificial
intelligence into education, explore innovative teaching methods, and reshape the virtual simulation
learning environment