bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnóstico socio ambiental de la “Finca La Vieja”, (Municipio de Cimitarra-Santander) como estrategia para determinar su potencial ambiental en la recuperación del ecosistema
Authors: Varón Román Yenni Alejandra , Quitian Rojas Alba Lucia
Published: April 2021

La fragmentación de bosques y la degradación de hábitats asociadas son consideradas como las principales causas de la pérdida de biodiversidad en Colombia, es ese sentido que urgen acciones que mitiguen y restablezcan ecosistemas afectados, para ello, una de las estrategias más importantes es la recuperación y restauración de ecosistemas. Sin embargo, ante estas estrategias surgen también una serie de implicaciones relacionadas con la ausencia de información o su falta de accesibilidad, tal como lo son datos actualizados de la flora y fauna amenazada, información satelital de las zonas afectadas, entre otras. En consideración, el presente documento tuvo como objetivo generar un diagnóstico socioambiental a partir de la caracterización del relicto boscoso asociado a la finca “La Vieja” y demás fincas asociadas, con el fin de determinar su potencial ambiental en la restauración del ecosistema local y el mantenimiento de los servicios que ecosistémicos. En ese contexto, el presente diagnóstico se desarrolló considerando factores biofísicos como la vegetación, la fauna y el componente social. Para dicho fin, se tuvo en cuenta información secundaria de instituciones y entidades regionales, así como de información recolectada a partir de recorridos en campo, entrevistas, diálogos con la comunidad y observaciones directa del estado de los principales sistemas boscosos. Como resultado de esta investigación se estimó que el estado actual de las fincas es óptimo en términos de la diversidad de fauna encontrada y del estado sus principales sistemas boscosos, de la misma manera se detectaron zonas de bosque débilmente conectadas por lo cual se propone un mapa de conectividad biológica.

La caracterización del ecosistema se desarrolló considerando factores biofísicos como la vegetación, la fauna y el componente social. Para dicho fin, se tuvo en cuenta información segundaria de instituciones y entidades regionales. Así mismo se llevaron a cabo recorridos en campo, se aplicaron entrevistas, se generaron diálogos con la comunidad y se observó de manera directa el estado de los principales sistemas boscosos.

A partir de la georreferenciación se generaron mapas relacionados con los cambios de la cobertura vegetal, usos del suelo y se propone así mismo un mapa de conectividad biológica, todo esto con el objetivo conocer el estado de los bosques a nivel de paisajes y formular mejores estrategias que permitan la conectividad del sistema boscoso.
Diagnostic significance of fat globules in blood in fulminant-type fat embolism syndrome
Authors: ASAKAGE AYU , Fujisawa Michiko , Takei Tetsuhiro , Kumagai Jiro
Published: April 2021

Detecting fat globules in blood in diagnosing fat embolism syndrome
(FES) remains controversial. This case illustrated two life threatening
episodes possibly due to FES, with a dramatic increases of fat globules
in blood. Significance of quantitative change of fat in blood in
diagnosing FES should be evaluated in the future.
Testing the transfer functions for Geonor T-200B and Chinese standard precipitation gauge (CSPG) in the central Qinghai-Tibet Plateau
Authors: Lele Zhang , Gao Liming , Chen Ji , Zhao Lin , Chen Kelong , Zhao Jingyi , Liu Guojun , Song Tingxi , Li Yankun
Published: April 2021

Geonor T-200B weighing precipitation gauge (Geonor) and Chinese standard
precipitation gauge (CSPG) are widely used for measuring precipitaion in
the Qinghai-Tibet Plateau. However, their measurements must be adjusted
due to wetting, evaporation loss and wind-induced undercatch. Some
transfer functions had been proposed in previous studies, but their
applicability in the Qinghai-Tibetan Plateau has not been evaluated. In
our study, a precipitation measurement intercomparison experiment was
carried out from August 2018 to September 2020 at a station in the
central Qinghai-Tibet Plateau, and these transfer functions are also
evaluated based on the results of the experiment. The results show that:
(1) the catch efficiency of Geonor for rain, mixed, snow, hail are
92.06%, 85.32%, 68.08% and 91.82% respectively, and the catch
efficiency of CSPG are 92.59%, 81.32%, 46.43% and 95.56%
respectively. (2) K2017b has the most accurate correction results for
Geonor solid and mixed precipitation at 30 minutes time scale, and the
M2007e scheme has the most accurate correction results for Geonor solid
precipitation at event scale. (3) The current transfer functions for
CSPG underestimate the solid precipitation, while overestimate the
liquid precipitation. Based on the results of the comparative
observation in our study, new CSPG transfer functions are proposed for
the central Qinghai-Tibet Plateau. (4) Hail is also an important
precipitation type in the central Qinghai-Tibet Plateau. Because the
capture rate of hail precipitation is close to that of rain, and the
temperature when hail precipitation occurs is high, it is not necessary
to determine the hail precipitation type, and the transfer functions
recommended in this study can also get a good correction results.
Ecological responses of three urban watercourse stretches after implementation of one-off recovering interventions: an integrated assessment
Authors: Primo Kristiane , Silva Alexandre da , Silva Rosiane e , Olimpio Beatriz , Silva Gabriela , Silva Ana Paula
Published: April 2021

Faced with the anthropic activities of urban streams stretches through
rectification with concrete, there is a concern about the modifications
of the aquatic habitats and consequent ecological damages to the
ecosystems. Based on biophilic engineering, there is a great opportunity
to idealize and test interventions to revitalize such hampered
ecosystems. Hence, we verified the performance of biological and organic
factors, after the implementation of one-off interventions in three
rivers using biophilic handmade materials and structural elements in
their fixation. We carried out the project in urban stretches of
concrete bed streams, located in Sorocaba-SP, Southeast of Brazil. In
two years, we conducted biweekly in situ and laboratory measurements to
characterize the study sites, idealize, scale, implement the projects,
and, evaluate the ecological responses of the implementations. We
collected sampling in two points: upstream and downstream interventions.
We evaluated the performance of the interventions through the analysis
of SWOT (Strengths, Weaknesses, Opportunities, and Threats) factors and
by using the Analytic Hierarchy Process (AHP). We presented the results
through a decision-making matrix for stakeholders, which indicated that
our ideas are of low cost and easy to implement. Then, we got the
following scenario of SWOT priorities: opportunity (58.55%), strength
(24.71%), threat (10.74%), and weakness (6.00%). They demand constant
efforts for maintenances and they need adjustments to a better
understood by residents and the watershed management. We concluded that
the strengths observed in the project turn our idea replicable in any
part because it attaches the idea of caring about the environment
through biophilic techniques, and the weaknesses are liable to
modifications (improvements) in future projects that consider such
proposal.
Shorter Periconception Maternal Telomere Length and the Risk of Congenital Cardiac Outflow Defects in the Offspring: a case control study
Authors: Fares Damiat Aoulad , Wiegel Rosalieke , Eggink Alex , Willemsen Sten , Meurs Joyce Van , Steegers-Theunissen Regine
Published: April 2021

Objective: Congenital cardiac outflow defects (COD) are the largest
group of congenital heart defects, with ventricular septal defect (VSD)
as the most prevalent phenotype. Increased maternal age, excessive
oxidative stress and inflammation are involved in the pathophysiology
and enhance telomere length (TL) shortening. We aim to study the
association between periconception maternal TL, as future predictive
biomarker, and the risk of having a child with COD. Design: HAVEN-study,
a multicenter case-control triad study conducted in the Netherlands.
Setting and population: 306 case mothers of a child with COD and 424
control mothers of a child without a congenital malformation were
selected. Methods: TL was estimated, on DNA from venous blood samples,
by qPCR. Multivariable logistic regression was used to compute crude and
adjusted odds ratios (OR) per standard deviation (SD) decrease between
maternal T/S ratio and COD and VSD risk. Main outcome measures: The risk
of COD in offspring. Results: A significant association was shown
between maternal TL shortening (per standard deviation) and a 29%
increased risk of VSD in offspring (OR 1.29(95% CI 1.04-1.61), P=
0,02), which remained significant after additional adjustment for
maternal age (adjOR 1.25(95% CI 1.01-1.55), P= 0,04). No association
between maternal TL and the risk of overall COD in offspring was
observed. Conclusion: Shortening of maternal TL, due to maternal
conditions including age, is associated with an approximately 1.3-fold
increased risk, per SD in TL-shortening, of VSD in the offspring. These
findings need further confirmation in other studies on the predictive
value of maternal TL.
A case of bone lesion in a patient with relapsed chronic lymphocytic leukemia and review of the literature
Authors: Bacchiarri Francesca , Gozzetti Alessandro , Mondanelli Nicola , Lazzi Stefano , Bocchia Monica
Published: April 2021

Skeletal involvement in CLL is very rare. We present a case of ileum
bone lesion during in a patient receiving 5th line of therapy. Despite
radiotherapy and salvage therapies, subsequent bone lesions led to a
fatal outcome. Further studies on the mechanism by which bone disease
develops are currently needed.
COVİD-19 AND HYPERAMYLASEMİA
Authors: Bacaksız Ferhat , Ebik Berat , Ekin Nazım , Kılıc Jehat
Published: April 2021

Object: Our aim is to evaluate the elevation of pancreatic enzymes in
COVID-19 patients and their relationship with severity of COVID-19.
Method: In this study, 1378 patients with COVID-19 infection were
included. Relation of elevated amylase and lipase levels and co-morbid
conditions with the severity of COVID-19 were checked. The effect of
hemodynamic parameters and organ failures on pancreatic enzymes and
their relations with prognosis were statistically analyzed. Results:
There were 678 (%49,2) female patients and 700 (50,8%) male patients.
Of all patients, 687 (49,9%) had mild, 691 (50,1%) severe COVID-19
infections. Elevated amylase levels were detected in 23% of patients
(n:316). 19% (261) of them had a slight (1-3 times) increase in amylase
levels, while 4% (55) had a more than 3 times increase in amylase than
normal. Only 6% of patients with elevated amylase leves had the acute
pancreatitis according to Atlanta criteria. According to univariate and
multivariate analyses, elevated amylase levels was found statistically
related with severity of COVID-19 (OR:4,37-p <0,001). And also
diabetes mellitus (DM) (OR:1,82-p:0,001), kidney failure (OR:5,18-
p< 0,001), liver damage (OR:6,63 p < 0,001),
hypotension (OR:6,86-p< 0,001), sepsis (OR:6,20-p:0.008) were
found to related to death of COVID-19. Conclusions: Elevated pancreatic
enzyme levels in COVID-19 infections is to related to severity of
COVID-19 infection and hemodynamic instability. Similar to other organs,
the pancreas can be affected by severe COVID-19 infection.
Tonic activation of VPAC1 receptors by VIP modulates theta-burst induced LTP in the hippocampus: transduction pathways and GABAergic mechanisms.
Authors: Rodrigues Nadia , Caulino-Rocha Ana , Ribeiro Joaquim , Cunha-Reis Diana
Published: April 2021

Background and purpose Vasoactive intestinal peptide (VIP), acting on
both VPAC and VPAC receptors, is a key
modulator of hippocampal synaptic transmission, pyramidal cell
excitability and synaptic plasticity phenomena, like long-term
depression (LTD), partly through modulation GABAergic disinhibitory
circuits. VIP effects on LTP and the involvement of disinhibition were
scarcely investigated. Experimental approach The influence of endogenous
VIP on CA1 LTP induced by TBS was evaluated in the CA1 area of
hippocampal slices using field-excitatory electrophysiological
recordings from young-adult Wistar rats using selective
VPAC and VPAC antagonists.
Phosphorylation of GluA1 AMPA receptor subunits and Kv4.2 potassium
channels was evaluated in hippocampal membranes obtained from such
slices by Western blot. Key results Here we show that VIP, acting on
VPAC (but not VPAC) receptors, is an
endogenous inhibitor of hippocampal LTP induced by theta-burst
stimulation (TBS) in the CA1 area of the hippocampus of young adult
Wistar rats. This effect is dependent on GABAergic transmission and
relies on the integrity of NMDA and CaMKII-dependent LTP expression
mechanisms but not on PKA and PKC activity. Furthermore, it regulates
the expression and Serphosphorylation of Kv4.2
potassium channels responsible for the A-current while inhibiting
phosphorylation of Kv4.2 on Thr. Conclusions and
implications Altogether this suggests that endogenous VIP controls the
expression of hippocampal CA1 LTP by regulating disinhibition through
activation of VPAC receptors in interneurons. This may
impact the expression and phosphorylation of Kv4.2 K
channels at hippocampal pyramidal cell dendrites.
The interaction between cerium dioxide, lanthanum and europium oxides at 1500°C
Authors: Andrievskaya Olena , Kornienko Oksana , Bykov Oleksandr , Chudinovich Olga , Spasonova Larysa
Published: April 2021

Materials based on CeO2-La2O3-Eu2O3 and La2O3-Eu2O3 systems are promising
candidates for a wide range of applications, but the phase relationship has
not been studied systematically previously. The phase relations in the
CeO2-La2O3-Eu2O3 ternary system at 1500?C and binary La2O3-Eu2O3 system at
1600-1500?C were studied in air by X-ray diffraction (XRD) investigation in
the overall concentration range. The isothermal section of the phase diagram
for the CeO2-La2O3-Eu2O3 system has been constructed. It was established that
in the ternary CeO2-La2O3-Eu2O3 system there exist fields of solid solutions
based on hexagonal (A) modification of La2O3, cubic modification of CeO2 with
fluorite-type structure (F), cubic (C) and monoclinic (B) modification Eu2O3.
It was established that in the binary La2O3-Eu2O3 system there exist fields
of solid solutions based on hexagonal (A) modification of La2O3 and
monoclinic (B) modification Eu2O3. The phases were separated by two-phase
fields (A+B). The refined lattice parameters of the unit cells for solid
solutions and microstructures of the definite field of compositions for the
systems were determined.
Structure and optical properties of porous SiC film grown by magnetron sputtering on porous anodic aluminium oxide template
Authors: He Zhenhua , Li Jieling , Liu Canhui , Zhu Shifei
Published: April 2021

Porous fluorescent SiC films were deposited by magnetron sputtering (MS)
using porous anodic aluminium oxide (AAO) template. In the first step AAO was
carefully placed on the Si substrate and then coated with SiC film using
magnetron sputtering at the deposition temperature of 873K for different
times. The pore diameter, pore spacing and thickness of the double pass
porous AAO template were 300, 450 and 500 nm, respectively. The SiC film
deposited for 60min showed macroporous structure with the pore size of 200 to
250 nm and pore spacing of 450 nm. The photoluminescence (PL) spectrum of the
porous SiC film ranged from 400 to 700 nm. The band gap of SiC is 2.305 eV,
and the phonon energy of phonon participating in PL of SiC is estimated at
0.075 eV. The source of phonon participating in PL of SiC may be from phonon
scattering of silica/SiC interface in porous SiC film. The porous AAO
template assisted magnetron sputtering is a promising technical processing
for the fabrication of macroporous fluorescent SiC film.
Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial
Authors: Qu Ling , Liang Xiaochun , Tian Guoqing , Zhang Gaili , Wu Qunli , Huang Xiumei , Cui Yazhong , Liu Yuling , Shen Zhufang , Xiao Changqing , Qin Yingfen , Miao Heng , Zhang Yongyan , Li Ziling , Ye Shandong , Zhang Xuezhi , Yang Jing , Cao Guiwen , Li Yi , Yang Gangyi , Hu Ji , Wang Xiaoyue , Li Zhengfang , Li Yukun , Zhang Xiuzhen , Zhang Guangde , Chen Li , Hua Wenjin , Yu Ming , Lu Chunyan , Zhang Xiaomei , Jiang Hong
Published: April 2021

OBJECTIVE

This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi alkaloids [SZ-A]) in the treatment of type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS

This was a multicenter, randomized, double-blind, double-dummy, and parallel controlled noninferiority clinical trial that was conducted for 24 weeks. A total of 600 patients were randomly allocated to the SZ-A group (n = 360) or acarbose group (n = 240). The primary efficacy end point was the change of glycosylated hemoglobin (HbA1c) compared with baseline. In addition, adverse events (AEs), severe AEs (SAEs), treatment-related AEs (TAEs), and gastrointestinal disorders (GDs) were monitored.

RESULTS

After treatment for 24 weeks, the change in HbA1c was –0.93% (95% CI –1.03 to –0.83) (–10.2 mmol/mol [–11.3 to –9.1]) and –0.87% (–0.99 to –0.76) (–9.5 mmol/mol [–10.8 to –8.3]) in the SZ-A and acarbose groups, respectively, and the least squares mean difference was –0.05% (95% CI –0.18 to 0.07) (–0.5 mmol/mol [–2.0 to 0.8]) between the two groups, with no significant difference on the basis of covariance analysis (P > 0.05). The incidence of TAEs and GDs was significantly lower in the SZ-A group than the acarbose group (P < 0.01), but no differences for AEs or SAEs between the two groups were observed (P > 0.05).

CONCLUSIONS

SZ-A exhibited equivalent hypoglycemic effects to acarbose in patients with T2D. Nevertheless, the incidence of TAEs and GDs was lower following SZ-A treatment than acarbose treatment, suggesting good safety.
Epistemology of Arabic Language Learning Technology Development
Authors: Nurcholis Ahmad , Nuryani Nuryani , Efendi Heri , Hidayatullah Syaikhu Ihsan
Published: April 2021

Students' lack of Arabic language skills might be caused by some factors, such as the models and strategies used by teachers, the students’ excitement in learning and their character. This study aimed to research on the epistemology of Arabic learning based on ICT. It was designed to find the Arabic learning model based on ICT. It assumed that integrating various fields of study with ICT, including Arabic language learning, is essential to be developed in this digital era. However, there are obstacles experienced by several schools, especially the teachers, they do not have a specific format for using ICT to integrate both scientific subjects. Descriptive qualitative research was used in this research. The data collection was done through observation, interviewing the teachers and one hundred X grade students, and documentation. The data were analyzed by using the Miles and Huberman technique. The results showed that the design of the ICT-based in Arabic learning model development is “al-hasub al-ittishalî”, this is an innovative Arabic learning model based on ICT. In this model, the materials and other learning tools are designed in a computer program. As stated by E. L. Criswell, computers provide opportunities for students to participate and respond to the student’s activities actively. This model contributes in making the teaching and learning process more effective. With this model, the teacher is expectedly able to become a learning motivator and a mediator to explain some materials to the students. Besides, the use of ICT is a must considering the digital era.
The Effectiveness of Grammatical Hunting Game Method Students’ Arabic Learning Motivation
Authors: Shodiq Muhammad Jafar , Zakiyah Zaimatuz , Hajib Zainal Abidin
Published: April 2021

This experimental research was motivated by the low Arabic learning motivation in class VIII MTsN 9 Bantul which was caused by the use of monotonous learning methods. This study aims to find out students' Arabic learning motivation after the application of Grammatical Hunting language educational game method and to compare the Arabic learning motivation of the experimental class and the control class. This study used a quasi-experimental research type. The sample of this research was students of class VIII B and VIII C of MTsN 9 Bantul Yogyakarta consisting of 60 students. Data were collected through observation, interviews, questionnaires, and documentation. The results of this study indicated that: 1) The student's Arabic learning motivation increased after the application of Grammatical Hunting language educational game method based on the results of the paired sample t-test with a significance value of 0.000 0.05, Ha was accepted. 2) There was a significant difference in the learning motivation of the experimental class and the control class, based on the results of the independent sample t-test with a significance value of 2.042 ≥ 2.001, Ha was accepted. This method could increase students' motivation to learn Arabic. This study contributed to the use of varied learning methods, so that qawā'id learning would become an enjoyable learning.
Jakość w działalności gospodarczej
Authors: Chrobocińska Katarzyna , Decyk Kamil , Szulc Radosław
Published: April 2021

W warunkach silnej konkurencji przedsiębiorcy poszukują takich instrumentów konku­rowania, które zapewnią im trwałą przewagę konkurencyjną. Rozpatrując całe spektrum możliwości, menedżerowie biorąc pod uwagę wymagania i oczekiwania klientów starają się doskonalić swoją ofertę. Oczekiwana wysoka jakość dóbr konsumpcyjnych, dostępnych po cenach rynkowych wzbudza zainteresowanie i pozwala stworzyć grupę stałych odbiorców. Za cel monografii przyjęto identyfika­cję roli i znaczenia jakości wpisującej się we współczesne paradygmaty działalności go­spodarczej. Jakość jest pojęciem interdyscyplinarnym, co implikuje jej wieloznaczność, a jednocześnie na tyle uniwersalnym, że występuje w wielu sferach życia społecznego oraz gospodarczego. W pierwszym rozdziale podjęto próbę przedstawienia spektrum podejść do pojęcia jakości oraz najważniejszych koncepcji kreowania jakości w procesie produkcyjnym. W rozdziale drugim zaprezentowano jakość oraz innowacje jako kategorie współistniejące, a także warunkujące konkurencyjność. Określono rolę oraz znaczenia jakości i bezpieczeństwa w działalności innowacyjnej sektora przedsiębiorstw przemysłowych w państwach członkowskich UE. W rozdziale trzecim przedstawiono zagadnienie jakości w odniesieniu do e-biznesu. Współczesny świat w narastającym stopniu opiera się o technologie komunikacji cyfrowej, które w różnym stopniu i zakresie implikowane są do funkcjonujących już przedsiębiorstw i przekształcają je w nowoczesne i innowacyjne przedsiębiorstwa działające w modelu hy­brydowym (clicks-and-mortar), a coraz częściej czystym biznesie internetowym (pure player). Koszty i korzyści wynikające z utrzymania wysokiej jakości mają subiektywny charakter. Zawsze jednak, jak długo będzie istniał wolny rynek i swoboda działania gospodarującego czło­wieka, ludzkie wybory, preferencje co do oczekiwanej jakości będą miały charakter subiektywny. Wysoka jakość i wysoka wartość dóbr mogą być synonimami, ale tylko gdy będą oznaczały spełnienie oczekiwań nabywcy.
El exotismo como umbral de lo fantástico en «La fiebre azul», de Cristina Fernández Cubas
Authors: Cabrera Espinosa Claudia
Published: April 2021

Este trabajo propone analizar el cuento “La fiebre azul”, de Cristina Fernández Cubas, con el objetivo de determinar la influencia del exotismo del país africano en donde se desarrolla la trama —en el que las supersticiones y antiguas creencias son parte de la cotidianidad— en la aparición del hecho fantástico. Asimismo, estudia el desdoblamiento de la personalidad del protagonista, hecho que constituye una ilegalidad en el relato, con el fin de comprender sus causas y de desentrañar la metáfora que implica.
Usos de objetos y anticipaciones corporales en el desarrollo temprano
Authors: Vietri Maximiliano , Alessandroni Nicolás , Piro María Cristina
Published: April 2021

Existe evidencia de que las interacciones diádicas contribuyen con la emergencia de la comprensión intencional. No obstante, poco se sabe acerca del rol que las interacciones triádicas (adulto-objeto-bebé) tienen en este proceso. Presentamos un análisis cualitativo de cuatro observaciones realizadas en el hogar, en Ensenada (Buenos Aires, Argentina). Dichas observaciones fueron un recorte de un estudio más amplio en el que se observaron, una vez por mes a lo largo de 7 meses, las interacciones de bebés con sus tutores y objetos. Los resultados muestran que los bebés anticipan corporalmente las acciones que los adultos realizan empleando objetos en situaciones de interacción triádica (adulto-objeto-bebé). La participación de los bebés en interacciones triádicas contribuye con la emergencia de anticipaciones corporales cada vez más complejas, coordinadas con el comportamiento de los demás y ajustadas a los usos canónicos de los objetos. Se defiende que estas anticipaciones son casos de comprensión intencional enactiva.
Directrices para el desarrollo de la interfaz gráfica de un sistema e-Health que facilite la visualización e interpretación de los datos relativos a los pródromos de episodios en pacientes con Alzheimer
Authors:   , López López Mónica Yazmín
Published: April 2021

La enfermedad de Alzheimer es una enfermedad neurodegenerativa, en constante aumento, que aqueja a millones de personas en México. Esta enfermedad no tiene cura y aquellos que la padecen requieren de cuidados especializados que, debido a la insuficiente cantidad de personal capacitado así como de instituciones de salud enfocadas a su detección y tratamiento, son proporcionados habitualmente por sus familiares y desde sus hogares, no contando con la infraestructura ni los conocimientos necesarios para ello, derivando en un inadecuado manejo y control de los pródromos que preceden a los episodios que caracterizan a esta demencia. Actualmente, existen tratamientos que, apoyados por la tecnología, ayudan a retrasar la aparición y control de los síntomas en quienes la padecen, mejorando la calidad de vida tanto del paciente como la de sus cuidadores. Así, puede hablarse de los sistemas e-Health, los cuales hacen posible un cuidado y monitoreo eficiente de los pacientes desde su lugar de residencia y por las personas que son sus responsables. Dicha situación da cabida a la presente investigación, la cual, basada en la definición de directrices de diseño y visualización de la información, como parte de una estrategia de diseño, validó la hipótesis que refiere a su aplicación en el diseño de interfaces gráficas para sistemas e-Health, de manera que éstas faciliten la visualización e interpretación de datos relativos a los pródromos en pacientes con Alzheimer. El presente documento hace referencia al desarrollo del proyecto.
Método de selección de técnicas de levantamiento de requerimientos para el desarrollo de software con un enfoque de Experiencia de Usuario
Authors:   , Vázquez Ceballos Darío Emmanuel
Published: April 2021

La presente tesis aborda una de las principales problemáticas en la fase inicial del desarrollo de software conocida como ingeniería de requerimientos. Se hace un análisis de las dificultades en las actividades que se pueden realizar en esta etapa: como la selección inadecuadamente de técnicas de levantamiento de requerimientos, no contar con una estrategia ni orden y ambigüedades en el entendimiento de las necesidades de los clientes. De estas observaciones se identificó la tarea de socializar el entendimiento de los requerimientos del software al equipo de desarrollo. En este proceso es un factor determinante en la comunicación y estrategia del equipo de desarrollo que impacta en el éxito del software. En este trabajo se propone una solución empleando artefactos esquemáticos a problemáticas en el levantamiento de requerimientos de software, considerando aspectos relacionados al diseño centrado en el usuario y la experiencia de usuario. El proceso se apega a lo propuesto por Scrum en el seguimiento de los requerimientos mediante una tabla que lleva registro del avance por cada ciclo de desarrollo (sprint). Como variante propuesta se incorpora el artefacto Kanban etiquetando los estados por columnas. Al problema del entendimiento de los requerimientos de software y su socialización adecuada al equipo se incorporaron propuestas de variantes de los artefactos: persona, descripción de escenarios, historias de usuario, mapa de experiencia del cliente y mapa de empatía. Estás variantes se han incorporado a la propuesta por el éxito conseguido en diferentes proyectos de software, en los que se puedo verificar el éxito al socializar adecuadamente los requerimientos de software entre los miembros del equipo, así como en la reducción de ambigüedades de los requerimientos recabados. La evaluación del proceso propuesto se realizó mediante la técnica Delphi con expertos. En los resultados de las rondas de preguntas y sus análisis, los expertos coincidieron que emplear los artefactos incorporados en el trabajo ayudan en el desarrollo de software y permiten una mejor comunicación entre los involucrados en la implementación del producto de software. El comité de expertos coincidió que emplear el proceso reduciría dificultades en las etapas iniciales del desarrollo y el uso de los artefactos propuestos permiten una mejor comunicación entre los miembros del equipo.
Estudio de los esquemas de control de cascada basados en múltiples mediciones de temperatura
Authors:   , Ramírez-Castelán Carlos Eduardo
Published: April 2021

Los reactores tubulares son difíciles de operar debido al acoplamiento entre los fenómenos de transporte, cinética no-lineal y su naturaleza distribuida. El objetivo esencial del control de reactores tubulares es la regulación de la concentración a la salida. Dado que las mediciones de composición generalmente conllevan retardos considerables debido a restricciones como el tiempo de respuesta de los equipos de medición y el transporte interno, un lazo cerrado de control basado únicamente en la composición puede sufrir un pobre desempeño e incluso inestabilidades. Para contrarrestar esta situación, un esquema de control en cascada de composición-temperatura es propuesto. El control en cascada propuesto se compone de una configuración anidada que consiste en un lazo interno de control de temperatura dirigido a cumplir el objetivo de estabilización y un lazo externo de composición con el objetivo de regular la concentración a la salida. En las configuraciones de control en cascada de reactores tubulares, el número apropiado además de la localización de sensores es un problema abierto. Diversos estudios demuestran que los sensores pueden ser colocados en las posiciones más sensibles, es decir la posición del punto más caliente del reactor (Hot spot). En este trabajo se estudió el problema de la localización de sensores para una configuración de control en cascada simple empleando dos métodos. El primero utilizando series de tiempo obtenidas a partir de condiciones de entrada del reactor forzadas aleatoriamente para las cuales se realiza un análisis fractal con el objetivo de localizar las zonas más sensibles del reactor. Por otra parte, se realiza un análisis de sensibilidad numérica local aproximada. Dos casos de estudio son tratados que consisten en modelos de reactor tubular de dispersión axial exhibiendo comportamientos tipo Hot spot y cuasi lineal.
Elementos de la picaresca en Casi el paraíso (1956) de Luis Spota
Authors:   , Gallo García Jorge
Published: April 2021

El objetivo de la presente investigación es analizar algunos de los elementos de la picaresca, en la novela de Luis Spota Casi el paraíso (1956), así como aspectos de la risa que están presentes para reforzar al personaje del pícaro. A pesar que esta obra fue escrita durante la segunda mitad de la década de los cincuenta, época en la que la literatura mexicana pasó por un momento de urbanización, donde la Ciudad de México se volvió parte de la misma narrativa, Casi el paraíso muestra elementos de la picaresca tradicional, y del mismo modo que se utilizó a este personaje en el género hispano, en dicha obra también sirve para evidenciar y denunciar los lujos y excentricidades de las clases altas, aunque en este caso, Spota lo hace como una sátira ácida en contra de los nuevos ricos surgidos después de la Revolución y gracias a los negocios realizados al amparo del gobierno.
Ensayos de mujeres indígenas: de la resistencia a la reflexión
Authors:   , Elena Ríos Mónica
Published: April 2021

El presente trabajo tiene como objetivo mostrar que el cultivo del género ensayístico entre las escritoras pertenecientes a pueblos originarios obedece a la necesidad de encontrar espacios que les permitan tomar la palabra para hacerse escuchar. La hipótesis que guía esta tesis es la siguiente: el ensayo de las mujeres indígenas es un contradiscurso donde, a través de la mirada endógena, es posible re-crear la imagen propia. El ensayo posibilita el fijar la memoria, así como narrar la historia a partir de su forma de conocer e interpretar el mundo. Con estos textos las escritoras intentan transgredir y desmantelar el discurso hegemónico que las representa de manera estereotipada. La literatura se erige como un espacio de reflexión y de resistencia tanto dentro como fuera de sus comunidades.
Resting heart rate and the use of β-blockers in the treatment of patients with arterial hypertension
Authors: Waliczek Martyna , Rozentryt Piotr
Published: April 2021

Higher resting heart rate was shown to correlate with worse prognosis both in general population and in various disease groups. Scientific societies dealing with patients with hypertension propose assessment of resting heart rate as a standard risk factor. In patients with uncomplicated hypertension and elevated resting heart rate they propose use of cardioselective β1-adrenolytics. This decision should be preceded by careful examination of potential modified reasons. In the paper we express several concerns regarding standard provision of heart rate lowering drugs in particular clinical situations. The algorithm showing proposed steps in assessment of elevated heart rate is provided.
Use of slow-acting symptomatic drugs in osteoarthritis. The effectiveness of the combination of glucosamine and chondroitin in the light of the evidence
Authors: Tłustochowicz Witold
Published: April 2021

Treatment of osteoarthritis requires the use of drugs that will slow down the destruction of articular cartilage and reduce joint pain. Slow-acting symptomatic medications are often used in daily practice. The most frequently used and considered the most effective preparations are glucosamine and chondroitin. High-quality studies have shown that the combination of this both substances is effective in slowing the progression of the disease and reducing pain, and is also safe, even with prolonged use.
Erectile dysfunction – a cardiologist’s point of view
Authors: Mamcarz Artur , Wełnicki Marcin
Published: April 2021

Cardiovascular disease is a common phenomenon, just like obesity, arterial hypertension and diabetes. Those diseases negatively affect all spheres of our life, including our sex life. The best known currently is the relationship between the occurrence of erectile dysfunction and diseases of the cardiovascular system. Erectile dysfunction may not only be a late consequence cardiovascular diseases, but also their early revelator. However, they can also be a side effect of some cardiac medications. Cardiosexology deals with these issues. Perhaps, however, an even more important issue is the safety of treating erectile dysfunction in patients with cardiovascular diseases.
Standardized bergamot polyphenolic fraction – a comprehensive dietary supplement with pleiotropic properties compared to other selected natural lipid-lowering substances available on the market
Authors: Barylski Marcin
Published: April 2021

Bergamot juice has a particularly high content and a unique composition of flavonoids. It is particularly rich in flavanones and flavones. Standardized bergamot polyphenolic fraction has the same polyphenol profile as in the juice, but flavonoids are over 200 times more concentrated. Many data show its brilliant performance in hyperlipidaemia and moderate hyperglycemia. In addition, compared to other dietary supplements available on the market, it has beneficial pleiotropic properties.
The combination of diclofenac and B vitamins – effectiveness and safety in clinical practice
Authors: Postuła Marek , Czajka Pamela , Fitas Alex
Published: April 2021

Diclofenac is one of the most commonly used non-steroidal anti-inflammatory drugs in the World, eagerly chosen for the therapy of skeletal, joint and muscle pain. However, the use of diclofenac is associated with side effects common for the entire class of drugs, including enhancement of cardiovascular risk. It has been shown that B vitamins are involved in many processes essential for the nervous system activity, as well as in the mechanism of initiating and transmitting pain stimuli. Besides, they have a synergistic analgesic effect when combined with diclofenac. Application of both drugs in analgesic therapy resulted in more effective pain relief, but also allowed for the reduction of diclofenac doses, leading to minimize the risk of side effects. The combination of B vitamins has a positive effect on the efficacy and safety of the therapy, which is important especially for low cardiovascular risk patients.
Azithromycin – application in the era of telemedicine
Authors: Sybilski Adam J.
Published: April 2021

The pandemic has forced the limitation of direct contact between doctors and patients. Telemedical visit appeared in doctor’s offices and became an indispensable form of medical procedure. This form of patient communication can change current models of medical care. Providing health services with the use of teleinformatic communication (e.g. telephone, internet) allows for the assessment of the patient’s health condition, diagnosis and treatment implementation. The assessment of photos taken by the patient may significantly bring the diagnostician closer to the correct diagnosis and be necessary for the implementation of effective treatment. However, when conducting a telemedical visit, the physician should exercise due diligence, conduct a thorough interview, describe the patient’s health condition and the resulting therapeutic decisions in the documentation, and describe the treatment method used. During telemedicine treatment of infections, we can use macrolides, including azithromycin. Over the many years of use, its good effectiveness, low bacterial resistance and an excellent safety profile have been confirmed. The clinical scenarios in which we can use azithromycin during the telemedical visit are patients with pharyngitis and allergic to β-lactam antibiotics, with documented pertussis (the whooping cough), and for the prophylaxis of traveler’s diarrhea. However, let’s remember about the limitations and pitfalls that may occur during the telemedical visit.
Isotherm and kinetics of methylene blue removal byMusa acuminatapeel adsorbents
Authors: Noor Nurul Huda Mohd , Zaini Muhammad Abbas Ahmad , Yunus Mohd Azizi Che
Published: April 2021

Adsorbents were derived from banana peel through chemical treatment using phosphoric acid, potassium hydroxide, and sodium hydroxide to adsorb methylene blue from water. The adsorption of methylene blue was performed at varying concentrations and contact times. The equilibrium data fitted well with Langmuir equation, with a maximum monolayer adsorption capacity of 99.28 mg/g (28%). Phosphoric acid-treated adsorbent exhibits a greater capacity despite a lower affinity than the other adsorbents. A two-stage batch adsorber model was developed to optimize the adsorbent dosage for performance evaluation. Banana peel is a promising resource of adsorbent for wastewater treatment.
Designing of the Machine for Cutting Transport Belts: Conceptual Works
Authors: Kale Aashutosh , Biszczanik Aleksandra , Wałęsa Krzysztof , Kukla Mateusz , Berdychowski Maciej , Wilczyński Dominik
Published: April 2021

Belt conveyors are commonly employed in manufacturing and excavation processes. One of the basic components of such equipment are flat transport belts which can be monolithic or composite. In both cases, the belts are most often made of plastic materials. The manufacturing process of flat transport belts usually involves two stages. During the first stage, belts of very high length of up to several hundred meters are manufactured with use of the correct technology for a given belt type. In order to be usable in the finished conveyor system, correct length of such belts is to be achieved. Considering the above, the subsequent stage of manufacturing requires cutting the belts down to the appropriate length and very often joining the ends to form a closed loop with specific circumference. In an attempt to answer the demand of the manufacturing industry, the authors took up design works on an automated device for crosswise cutting of monolithic and composite belts. This article presents three construction concepts of the authors’ own design together with an analysis of construction and operating factors which affect their usability. The presented discussion leads to selecting one of the solutions for which a drive system concept designed by the authors is proposed. Additionally, an analysis of the influence of the cutting knife geometry on cutting force is provided.
Comparing maxillary first molar crown shape using elliptical Fourier analysis in the Late Neolithic cave burials of Belgium
Authors: Bryan Brandon Cory , Williams Frank L’Engle
Published: April 2021

The Belgian Meuse karstic basin holds more than 200 Late Neolithic collective burials. Four of the largest include Hastière Caverne M, Hastière Trou Garçon C, Sclaigneaux and Bois Madame. The remains from these caves are commingled and fragmentary. However, in situ maxillary molars are well preserved permitting an investigation of molar crown shape within and across sites. Crown outlines from the burials are compared using elliptical Fourier analysis to capture shape distinctions in the relatively numerous first maxillary molars (n = 27). Elliptical Fourier analysis is designed to compare deviations between each shape outline and an idealized ellipse, recorded as amplitudes of the harmonics which are reduced to principal components (PC) scores. We expect individuals from each site will be more similar to one another than to other internments in PC scores, and that the sites will be distributed along PC axes according to differences in chronology and geographic location. Principal components analysis reveals that individuals tend to cluster together based on cave burial as well as time period. Geographic distance only differentiates the final/late Neolithic cave burials. The earliest of the sites, Hastière Caverne M, is distinctive and includes multiple outliers. Hastière Trou Garçon C from earlier in the Late Neolithic does not cluster with Hastière Caverne M as expected. Instead, this cave burial groups with Sclaigneaux, the most geographically distant site but chronologically the closest to Hastière Trou Garçon C. Although the limited sample sizes for each site must be considered, it appears that early farmers of the Belgian Meuse basin exhibited intricate human population dynamics which may have included small, semi-isolated groups early in the Late Neolithic and larger communities with greater contact toward the onset of the northern European Bronze Age.
Obstetric history and its association with cardiometabolic risk factors: a case-control study among Bhil Women of Rajasthan, India
Authors: Kushwaha Savitesh , Mishra Jyoti , Mondal Prakash Ranjan
Published: April 2021

Pregnancy and childbearing are special reproductive events having an impact on women’s health and demographic trends. Reproductive health is not only linked to biological events of gestation and birth, but also are intricately linked to women`s status and their role in society. The current study focuses on the impact of bad obstetric history in the development of cardiometabolic risk factors. The present retrospective case-control study was conducted among Bhil tribal women of Rajasthan, India. A total of 287 women participated in this study which included 125 cases and 162 controls. Data on somatometric measurements, physiological measurements and lipid profile were recorded and analysed using SPSS version 25.0. The mean number of conceptions differed significantly between pregnancy in cases (5.06±1.85) and pregnancy in controls (3.19±1.56). Cases were characterised with significantly increased mean SBP (p=0.010), although the values (116.68±23.04) fell within the normal range. Bad obstetric history was found to be a risk factor for central obesity, hypertension and dyslipidemia among the Bhil women. It was also found to be relatively associated with adverse demographic/lifestyle variables which could enhance the effect of cardiometabolic risk factors. Women with bad obstetric history need special care and lifestyle variables need to be adjusted for better health outputs.
The Evaluation of Arthrospira platensis Bioactivity and their Dietary Supplementation to Nile Tilapia Vegetarian Diet on Growth Performance, Feed Utilization, Body Composition and Hemato-Biochemical Parameters
Authors: Mansour Abdallah Tageldein , Alsaqufi Ahmed Saud , Alkhamis Yousef A. , Al-Gazar Faten Fathy , Zaki Mohamed Abdullah , Nour Abdel Aziz Moussa , Ramadan Khaled M. A.
Published: April 2021

The present study aimed to identify the carotenoid content and evaluate the antioxidant activities of spirulina, Arthrospira platensis (in vitro), and the effect of its supplementation to a vegetarian diet on growth performance, feed utilization, body proximate composition and physiological status of Nile tilapia, Oreochromis niloticus (in vivo). The carotenoid content of spirulina was identified by UPLC-MS/MS and showed that trans and cis β-carotene were the major carotenoids (88.3%) followed by β-cryptoxanthin and zeaxanthin. The antioxidant activity of spirulina was determined in water and crude carotenoid extracts by 2,2-diphenyl-1-picryhydrazyl (DPPH) scavenging assay, both extracts showed a significant free radical scavenging capacity. In addition, Nile tilapia fry (0.83 ± 0.01 g) was fed a vegetarian diet supplemented with different levels of spirulina for 12 weeks. The results revealed that the highest growth performance and nutrient utilization were recorded with 0.5% spirulina and the peak response determined at 0.63%-0.65% using polynomial second order regression. Also, the hemoglobin content improved in a quadratic regression model with the peak at 0.67% spirulina. Plasma total protein and lipid contents increased significantly with spirulina levels over 0.50%. Moreover, the aminopeptidase activities and glucose level decreased significantly with increasing spirulina levels. The current study recommended the supplementation of the Nile tilapia vegetarian diet with spirulina at levels of 0.63-0.65% for better growth performance and physiological status.