bluuebunny/crossref_metadata_2025 huggingface dataset:
Hospitalisierungen, klinische Charakteristika und Antibiotikagabe bei akutem, schweren Asthma im Alter von 6 bis 17 Jahren
Authors:   , von Blumröder Malin Kristina
Published: July 2023

Hintergrund: Asthma ist die häufigste chronische Krankheit bei Kindern und Jugendlichen. Asthma-Exazerbationen sind ein häufiger Grund für Vorstellungen in der Notaufnahme und für Krankenhausaufenthalte. Die routinemäßige Gabe von Antibiotika bei einem akuten schweren Asthma wird von den Leitlinien nicht empfohlen, trotzdem erfolgt sie sowohl im ambulanten als auch im stationären Bereich. Das primäre Ziel dieser Promotion war es, die Häufigkeit der Gabe von Antibiotika während Asthma-Exazerbationen, die eingesetzten Antibiotikaklassen, den Einfluss des CRP Spiegels und die klinischen Kriterien, die zur Antibiotikagabe führten, zu analysieren. Methoden: Es handelte sich um eine retrospektive Analyse von 660 Kindern und Jugendlichen im Alter von 6 bis 17 Jahren, die während eines Zeitraums von 10 Jahren (2008 - 2018) mit der ICD Diagnose Asthma Bronchiale (J.45) stationär am Universitätsklinik Frankfurt/Main stationär behandelt wurden. Akutes, schweres Asthma wurde definiert als Dyspnoe, Tachypnoe, Sauerstoffbedarf und/oder systemische Steroidtherapie. Antibiotikagabe ohne Indikation wurde definiert als Gabe von Antibiotika bei einem CRP <2 mg/dl, keiner radiologischen Evidenz einer Pneumonie, oder keiner Indikation zur Durchführung eines Röntgenbildes und keinem anderen Grund zur Antibiotikagabe. Analysiert wurden u.a. Alter, Geschlecht, Intensivstationsaufenthalt, Liegedauer, Erstdiagnose oder bekanntes Asthma, Sauerstoffbedarf, Laborparameter, Lungenfunktion, Röntgen, Phänotypen, Therapie und Anzahl der Re-Hospitalisierungen. Ergebnisse: 350 Aufnahmen erfüllten die Einschlusskriterien. Es erfolgte bei jüngeren Kindern häufig eine Antibiotikagabe (6 - 11 Jahre 57,6% und 12 - 17 Jahre 39,7%). Bei 26% der Aufnahmen wurde ein Antibiotikum ohne Indikation verabreicht, dabei waren Makrolide die häufigste Antibiotikaklasse. Die Gruppe der PatientInnen, die ein Antibiotikum ohne Indikation erhielten, unterschieden sich von der Gruppe, die kein Antibiotikum erhielten in Alter (9 ± 6 Jahre vs. 11 ± 6 Jahre; p-Wert 0,024), Sauerstoffbedarf (46,2% vs. 26,3%; p<0.001) und CRP-Wert (0,79 ± 0,92 mg/dl vs. 0,23 ± 0,46 mg/dl; p<0.001), aber nicht im Vorhandensein von Fieber (14,3% vs. 10,6%; n.s.). 10,3 % der PatientInnen wurden in den 10 Jahren re-hospitalisiert. Es fanden sich klinisch keine Unterschiede zwischen den re-hospitalisierten PatientInnen und den anderen Patienten. Schlussfolgerung: Antibiotikagabe ohne klare Indikation während einem akuten, schweren Asthma war in unserer Kohorte häufig. Klinische Parameter einer schwereren Erkrankung beeinflussten die Entscheidung zur Antibiotikagabe, obwohl keine Hinweise auf eine bakterielle Infektion vorlagen und nicht zu einem verbesserten Outcome führten. Gründe der Re-Hospitalisierung von PatientInnen sollten weiter untersucht werden, mit besonderem Fokus auf ausreichende Allergiediagnostik und Evaluierung der Compliance.
Caracterização dos Microrganismos Presentes na Cavidade Oral e Orofaringe de Pacientes Acometidos pelo Câncer de Cabeça e Pescoço Atendidos em um Centro Odontológico Localizado no Agreste Pernambucano: Estudo Piloto
Authors: Silva Iran Alves da , Alves Gabriela Quirino , Barbosa Larissa Karine , Santana Breno Washington Joaquim de , Laurentino Maria Gabriela , Alves José Victor Leal , Mota Cláudia Cristina Brainer de Oliveira , Oliveira Sibele Ribeiro de , Peres Adrya Lúcia
Published: July 2023

Introdução: A cavidade oral e a orofaringe apresentam uma gama diversificada de microrganismos em homeostase com o próprio hospedeiro, entretanto, a terapia antineoplásica pode desencadear uma imunossupressão capaz de provocar diversas alterações nesses indivíduos. Objetivo: Caracterizar os microrganismos da cavidade oral e orofaringe de pacientes acometidos pelo Câncer de Cabeça e Pescoço (CCP) em tratamento com antineoplásicos, atendidos em um Centro Odontológico localizado no Agreste Pernambucano. Métodos: Trata-se de um estudo caso controle (17 indivíduos do grupo estudo acometidos por CCP e 17 indivíduos do grupo controle), em que foram realizadas coletas microbiológicas através de esfregaço com swabs no assoalho bucal e orofaringe, posteriormente processadas para identificação microbiana através de testes fenotípicos. A verificação do perfil de resistência foi realizada seguindo a difusão em disco de Kirby-Bauer. Resultados: Os isolados corresponderam à presença do gênero Candida em todos os pacientes, além de bactérias oportunistas, sendo Enterobacterales, Staphylococcus ssp., Enterococcus ssp. mais predominantes no grupo estudo (67,64%). Foi detectada multiressistência de bactérias oportunistas a várias classes de antibióticos, como aminoglicosídeos, carbapenêmicos, cefalosporinas, fluoroquinolonas, glicopeptídeos, macrolídeos e penicilinas. Já entre as bactérias da microbiota normal, os Streptococcus viridans foram menos prevalentes no grupo estudo, correspondendo a (32,35%). Conclusão: O microbioma oral e orofaríngeo sofreu mudanças significativas nos pacientes em tratamento antineoplásico, podendo contribuir para o aumento da susceptibilidade a infecções por microrganismos multirresistentes que podem limitar as opções terapêuticas.
Caracterização do Uso de Fitoterápicos e Plantas Medicinais em Pacientes Atendidos em um Centro Oncológico de Pernambuco, Brasil
Authors: Silva Iran Alves da , Torres Sabrina Bezerra , Cruz Adyla Fernanda Silva da , Guinho Gleiciane Adrielli Souza , Barros Nyelle Nunes , Pereira Samara Marques de Oliveira , Cabral Analúcia Guedes Silveira
Published: July 2023

O uso de produtos naturais tem sido cada vez mais comum em pacientes oncológicos, contudo, a identificação da utilização de plantas medicinais e derivados pode ser essencial para promover a saúde e segurança na terapia antineoplásica. O objetivo deste estudo foi caracterizar o uso de produtos naturais em pacientes atendidos em um Centro oncológico em Caruaru-PE. Trata-se de um estudo transversal, quantitativo e descritivo, realizado em um Centro oncológico de Caruaru-PE entre fevereiro e agosto de 2022. A amostra foi obtida por conveniência, tendo como instrumento de coleta um questionário aplicado. Participaram do estudo 140 indivíduos, correspondendo a 77,90% mulheres e 22,10% homens. Sendo que 64,30% do total de pacientes usavam plantas medicinais, as mais prevalentes foram o capim-santo (40%), a camomila (34,44%) e a erva-cidreira (30%), sendo a decocção e o consumo semanal os modos de usos mais frequentes. Já os fitoterápicos mais utilizados foram a base de Passiflora incarnata e própolis. A maioria dos participantes incluídos nesse estudo, utilizam produtos naturais, como decocto de plantas medicinais e fitoterápicos com propriedades calmantes, pelo menos uma vez na semana. É necessário a divulgação de informações sobre os potenciais efeitos adversos no uso para garantir a saúde e segurança.
Photodestruction of active pharmaceutical substances in the presence of hydrogen peroxide and peroxydisulfate
Authors: Ivantsova N. A. , Vetrova M. A. , Churina A. A. , Andriyanova D. V.
Published: July 2023

Studies into photochemical oxidation can enhance the current understanding of degradation processes within aqueous solutions of active pharmaceutical ingredients (APIs). APIs are complex decomposable compounds that, once in reservoirs, cause irreversible consequences in living organisms. The results obtained on the photodestruction of various drugs in water in the presence of hydrogen peroxide and peroxydisulfate contribute to gaining new practical and theoretical knowledge in the field of water treatment, post-treatment, and purification. The paper presents laboratory results on the oxidation of model aqueous solutions of nitrofural, tetracycline, and paracetamol under the combined effect of UV radiation with micro-additives of oxidants (hydrogen peroxide and peroxydisulfate). The reaction order of APIs destruction is determined by the least square method. The results show that the combined effect of UV radiation and microadditives of hydrogen peroxide and peroxydisulfate contributes to both a high degree of purification (up to 98%) and a high rate of oxidative degradation of APIs (nitrofural, tetracycline, and paracetamol) compared to the use of UV radiation separately. The studied drugs can be arranged in the following order in terms of their oxidative degradation transformation ability: nitrofural>tetracycline>paraceta mol. The paper theoretically proves that photochemical destruction in the presence of peroxydisulfate leads to the formation of more highly reactive oxygen-containing radicals, which are involved in the decomposition of nitrofural, tetracycline, and paracetamol.
Estimation of substance distribution in the soil-plant system (on the example of crop species)
Authors: Belykh L. I. , Timofeeva S. S.
Published: July 2023

Assessment of the distribution of nutrients and pollutants in the soil-plant system is a relevant theoretical and applied task in biogeochemistry, agrochemistry and environmental biotechnology. Pointwise, average and extreme values of the concentration of the studied substance in the plant (Cp) and in the soil (Cs), as well as biological absorption coefficients (Kab=Cp /Cs), do not characterize the distribution of the studied substance in the system. This work investigates the effect of substance concentration in a soil on its distribution between the plant and the soil. The use of the Cp=f(Cs) and Kab=f(Cs) functions for describing the substance content in the plant depending on its concentration in the soil, allowed us to propose approaches to quantitative assessment of the distribution process. The first approach consists in the approximation of dependences by Freundlich and Langmuir linear or adsorption power functions Cp=f(Cs), on which basis the concentration parameters of а, 1Кр, Кр, С∞are determined. These parameters are used to study the mechanism and intensity of substance accumulation by a plant. The second approach includes obtaining a power function Kab=f(Cs) or its linear representation lgKab=f(lgCs) and calculating standardized coefficients Kab. These coefficients are sensitive at low (1, 10) and limiting at high (100, 1000) concentrations of the studied substance in the soil. The example of benz(a)pyrene, fluorine and zinc, i.e., substances different in terms of their physical, chemical and biological properties, was applied to demonstrate the process of determining the absolute and relative accumulation of the substances by different crop species. A comparison of different plants was conducted; possible mechanisms of the distribution of the studied substances and their intensity are considered.
Sugar in the hospitality industry
Authors: Samilyk Maryna , Paska Mariia
Published: July 2023

This study is designed to reveal the role of sugar in the hospitality industry. The purpose of the study is to analyze the range of sugar used in restaurant technologies and develop recommendations for its expansion and application, the creation of a gastronomic brand based on sugar. The subject of the study was the fruits of wild plants: viburnum (Viburnum opulus), sea buckthorn (Hippophae rhamnoides L.), elderberry (Sambucus nigra), mountain ash (Sorbus aucuparia) and fortified sugar. It is proposed to enrich sugar with a derivative product of processing wild fruits by the method of osmotic dehydration (sugar solution). It is expedient to use this technology in craft industries. An analytical review of literary sources was carried out, on the basis of which directions for the use of various types of sugar in restaurant technologies were formulated. It has been established that the high cost of imported sugars contributes to an increase in the cost of products with their use. The methodological basis for creating a gastronomic brand was the improvement of approaches to the cultural branding of Ukraine in the international arena by planning the development of "gastronomic tourism" not only as a tourist attraction, but also as a tool for implementing the strategy of public diplomacy. The gastronomic brand "Noble Sugar" was developed on the basis of local raw materials. Directions for the use of fortified sugar in the production of many foods and drinks have been developed, which can be attributed to gastronomic innovations. The presented products are unique and have no analogues in the hospitality industry
Research of phenolic compounds content in yoshta berries for the perspective of cultivation and use in healthy nutrition in the steppe zone of Ukraine
Authors: Lykholat Olena , Khromykh Nina , Lykholat Tetyana , Didur Oleh , Kvitko Maksim , Lykholat Yuriy
Published: July 2023

Unfavourable socio-economic conditions and unbalanced nutrition, expressed in the deficiency of biologically active substances, determine the need to use fruit crops as a source of biologically active substances. In world practice, priority is given to fruit plants that have biological activity useful for the human body. The relevance of the concept of balanced natural nutrition is increasing with the growth of the global population. Products containing pesticides, preservatives, artificial colors and flavors or other chemicals are included in the "black" list of all natural food advocates.

Jošta fruits is a low-calorie berry, 100 g of berries contain only 45‒48 calories. Nutritional value of yoshta (per 100 g of product): carbohydrates ‒ 9.1 g; fats ‒ 0.2 g; proteins ‒ 0.7 g; water ‒ 80 g. Jošta fruits contains vitamin C (ascorbic acid) in large quantities, vitamin P (rutin), pectin substances, phytoncides, organic acids, sugar, anthocyanins, potassium, iron, iodine, copper, etc. And the anthocyanins included in its composition accelerate metabolic processes and are capable of breaking down fats. Pectins improve and normalize intestinal microflora, which in turn contributes to cleansing. The aim of the work was the study of Jošta plant as a promising species for further possible ecological diversity of the territory of the right bank of the Dnieper in Ukraine.

The rare currant-gooseberry hybrid Jošta plant can be recommended for growing and using fruit products in functional human nutrition. The Jošta can be recommended for the cultivation and use of fruit products in functional human nutrition and, in particular, in the restaurant business namely locavores for the presentation of the author's intellectual interpretation of local products
Intention to Continue Adopting Online Problem-Based Learning After the COVID-19 Pandemic: Perception Analysis Using a Structural Equation Modelling Approach
Authors:   Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia, Chew Keng Sheng , Ahmad Razali Shazrina ,   Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia, Chawau Norman ,   Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia, Tan Wei Shing ,   Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia, Alfian Afina ,   Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia, Chandra Shekar Syarmeelah ,   Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia
Published: July 2023

Due to the COVID-19 pandemic, conventional face-to-face problem-based learning (PBL) had to be transitioned into online PBL. However, it was largely unknown how likely would medical students continue to adopt this form of hastily implemented remote learning solution after the pandemic ends. Using a two-stage partial least squares structural equation modelling approach, a study was conducted to develop a set of questionnaires to measure this intention and determine the influence of perceived benefits (5 items) and perceived ease of use (7 items) on the behavioural intention to continue adopting online PBL. The technology acceptance model was adopted as the conceptual framework of this study. Environment factors (11 items derived from PEST analysis, where P = policy, E = economic, S = social, and T = technology factors) were incorporated as the third independent construct in our model. A total of 149 Year 2 medical students participated in this study. Overall, the mean score for behavioural intention to continue adopting online PBL was 3.42 out of 5 (where 1 = most unlikely and 5 = most likely). Only the construct perceived ease of use had significant influence on the behavioural intention to continue adopting online PBL (path coefficient standardised β = 0.312; t-statistics = 2.960; p = 0.003). Perceived benefits and environment factors were not shown to have significant influence. In conclusion, as no strong intention to continue adopting online PBL was demonstrated in this study, conventional face-to-face PBL should be resumed until clear benefits of a carefully designed online PBL can be demonstrated.
Differential Impact of COVID-19 on Junior Doctors
Authors:   Royal Bournemouth Hospital, Castle Lane East, United Kingdom, Dattoo Maryam , Azhar Jawad ,   Royal Bournemouth Hospital, Castle Lane East, United Kingdom, Raza Tanzeem ,   Royal Bournemouth Hospital, Castle Lane East, United Kingdom, Vassallo Micheal ,   Royal Bournemouth Hospital, Castle Lane East, United Kingdom
Published: July 2023

The COVID-19 pandemic had a significant impact on the working circumstances for doctors. To cope with increased workload, hospitals had to increase working hours, reallocate vacation and study leaves and rotations. This impacted the physical and mental well-being of all doctors, particularly international medical graduates (IMG). We explored the differential impact on junior doctors working in a district general hospital. In a mixed methods study, we evaluated the experience and perception of junior doctors in a United Kingdom district hospital in the south of England during the first wave of COVID-19 between March 2020 and September 2020. The study was conducted in two phases: creating a questionnaire followed by an evaluation of qualitative and quantitative content. About 83% doctors in non-consultant grades responded and 37.8% were IMG. The study found that IMG were significantly more likely to experience stress when compared to UK medical graduates (p = 0.008). They were also more worried about contracting the virus when compared to UK medical graduates (p = 0.004). Both groups felt that their training and career progression had been adversely affected. Various factors could play a role in increased stress in IMG when compared to UK medical graduates. These factors included: adjusting to a new system, being away from family, exams and interviews being cancelled, and reports suggesting that members of the the Black, Asian and Minority Ethnic (BAME) community were more likely to be affected by serious illness if contracted COVID-19. This highlights the need for additional support for IMG.
THE EFFECT OF SURVIVOR’S BENEFITS ON WOMEN’S EMPLOYMENT: AN EXAMPLE IN TURKEY
Authors: ŞAHİN KESKİN Gülnaz , ÇAVLİN Alanur
Published: July 2023

Türkiye'de kadın istihdamı erkek istihdamının gerisindedir. Literatürdeki çalışmalar eğitim durumu, yaş, tarımsal çözülme, aile içi sorumluluklar, çocuk ve yaşlı bakımının kurumsal yetersizliği gibi nedenlerle kadın istihdamının erkek istihdamından düşük olduğuna dair hipotezler içermektedir. Ancak kadınlara doğrudan yapılan sosyal yardımların kadınların istihdamlarına ve kayıtlı ekonomiye entegre olmalarına etkisini ölçen çalışma yok denecek kadar azdır. İşte bu çalışma ile ailede çalışan kişinin vefatı halinde geride kız çocuklara bağlanan dul ve yetim aylıklarının hem kadınların istihdamlarına hem de kayıtlı istihdamlarına etkisi ölçülmektedir.

Hayatta kalanlar için emeklilik maaşları, ailede aktif olarak sigortalı çalışan kişinin erkek olduğu, erkek çocukların yetişkin olduklarında işgücü piyasasına girmeleri gerektiği ve kadınların çalışmak zorunda olmadıkları anlayış ile düzenlenmiştir. Böylece kadınlar bu emekli maaşlarını neredeyse hayatları boyunca bir tür kadın emekli maaşı olarak almaktadırlar. Çalışmada Gelir ve Yaşam Koşulları Araştırması, 2017 yılı verisi birincil kaynak, Sosyal Güvenlik Kurumu 2020 verisi ise ikincil kaynak olarak kullanılmıştır. Sonuçta, kadınlara yetim aylıklarında yapılan pozitif ayrımcı uygulamaların onları kayıtlı istihdamdan alıkoyan özelliği olduğu ve bu yönünün sosyo-ekonomik politikalarla bertaraf edilmesi gerektiği kanaatine varılmıştır.
The scattering and neutrino detector at the LHC
Authors: De Lellis Giovanni
Published: July 2023

SND@LHC, Scattering and Neutrino Detector at the LHC, is a compact experiment designed to perform measurements with neutrinos produced at the LHC in the unexplored pseudo-rapidity region of 7.2 < \etaη < 8.4, complementary to all the other experiments at the LHC. The experiment was approved in March 2021. It was constructed in about one year and it is now taking data during the Run 3 of the LHC. In this paper we review the detector concept, the physics case and the status of the data taking.
Exploring coherent elastic neutrino-nucleus scattering of reactor neutrinos with the NUCLEUS experiment
Authors: Goupy Chloé , Abele H. , Angloher G. , Bento A. , Canonica Lucia , Cappella F. , Cardani Laura , Casali N. , Cerulli R. , Colantoni I. , Cruciani Angelo , del Castello G. , del Gallo Roccagiovine M. , Doblhammer A. , Dorer S. , Erhart A. , Friendl M. , Garai A. , Ghete V. M. , Hauff D. , Jeanneau F. , Jericha E. , Kaznacheeva Margarita , Kinast Angelina , Kluck Holger , Langenkämper Alexander , Lasserre Thierry , Lhuillier D. , Mancuso M. , Mauri B. , Mazzolari Andrea , Mazzucato E. , Neyrial H. , Nones C. , Oberauer L. , Ortmann T. , Pattavina Luca , Peters L. , Petricca Federica , Potzel Walter , Pröbst F. , Pucci F. , Riendl F. , Rogly R. , Romagnoni M. , Rothe J. , Schermer Nicole , Schieck J. , Schönert S. , Schwertner C. , Scola L. , Soum Sidikov G. , Stodolsky L. , Strauss R. , Tamisari M. , Tomei Claudia , Vignati M. , Vivier M. , Wagner V. , Wex A.
Published: July 2023

The NUCLEUS experiment aims to perform a high-precision measurement of Coherent Elastic Neutrino-Nucleus Scattering (CEvNS) at the EdF Chooz B nuclear power plant in France. CEvNS is a unique process to study neutrino properties and to search for physics beyond the Standard Model. The study of CEvNS is also important for light Dark-Matter searches. It could be a possible irreducible background for high-sensitivity Dark-Matter experiments. NUCLEUS is an experiment under construction based on ultra-low threshold (∼20 eV20eV_{nr}) cryogenic calorimeters, operated at tens-of-mK temperatures.
Mergers as a probe of particle dark matter
Authors: Ray Anupam
Published: July 2023

Black holes below Chandrasekhar mass limit (1.4 M_{\odot}M☉) can not be produced via any standard stellar evolution. Recently, gravitational wave experiments have also discovered unusually low mass black holes whose origin is yet to be known. We propose a simple yet novel formation mechanism of such low mass black holes. Non-annihilating particle dark matter, owing to their interaction with stellar nuclei, can gradually accumulate inside compact stars, and eventually swallows them to low mass black holes, ordinarily impermissible by the Chandrasekhar limit. We point out several avenues to test this proposal, concentrating on the cosmic evolution of the binary merger rates.
What charged cosmic rays tell us on dark matter
Authors: Salati Pierre
Published: July 2023

Dark matter particles could be the major component of the haloes of galaxies. Their mutual annihilations or decays would produce an indirect signature under the form of high-energy cosmic-rays. The focus of this presentation is on antimatter species, a component so rare that any excess over the background should be easily detected. After a recap on Galactic propagation, I will discuss positrons, antiprotons and anti-nuclei. For each of these species, anomalies have been reported. The antiproton excess, for instance, is currently a hot topic. Alas, it does not resist a correct treatment of theoretical and data errors.
Changes in the Structure of Global Food Demand
Authors: Cranfield John , Hertel Thomas , Eales James , Preckel Paul
Published: July 2023

A newly developed demand system is used to estimate the response of food and food product demand to per capita expenditure changes. The resulting Engel elasticities are then used to project food and food product demand in 2020 assuming per capita expenditure and population changes. Results suggest that while food expenditure is projected to grow, it accounts for a smaller proportion of total expenditure. Further analysis indicates change in the composition of food demand away from a grain and towards livestock is projected to occur in lower income countries in 2020.
Hydrochemical characterisation and identification of seawater intrusion in the Visakhapatnam coastal aquifer
Authors: Mythilee Priyanka Venna , Maddamsetty Ramesh , Yarramalle Srinivas
Published: July 2023

Groundwater dependency has increased due to several factors like population increase, industrialization, and climate change impact. Analysis of groundwater is important to know the present status and also for better management of natural resources. Groundwater samples from 41 locations were collected along the study area during the pre and post-monsoon seasons, and samples were analysed for pH, EC, total dissolved solids (TDS), major cations, and anions like Ca2+, Mg2+, Na+, K+, Cl−, HCO3− and SO42−. From the chemical analysis results, seawater intrusion is identified through qualitative approaches, i.e., Simson ratio (Cl/(HCO3 + CO3) and Na/Cl ratio. Simson ratio ranges between 0.316 to 2.119 during pre-monsoon and 0.124 to 3.947 during post-monsoon, and from Na/Cl ratio, 30 samples fell under seawater intrusion during pre-monsoon and 38 samples during post-monsoon. The Simpson ratio results also show that seawater intrusion is reducing during the post-monsoon due to increasing groundwater levels caused by rains. From the water quality index classification, 4.88% of the water samples fell under excellent in both seasons, and the rest of the samples were all in the remaining four classes. The spatial analysis was also done to understand the changes in groundwater quality and seawater intrusion over space.
necessidade e os paradoxos da linguística integral
Authors: Agud (Autora) Ana , Pinheiro (Tradutor) Clemilton Lopes , Parducci Soares de Lima (Tradutor) Mateus
Published: July 2023

A ideia de uma “linguística integral” de Coseriu precisa de uma reflexão profunda, pois engloba dois objetivos diferentes e parcialmente incompatíveis: neutralizar a extrema fragmentação da pesquisa linguística moderna através da reflexão filosófica sobre a verdadeira natureza da “linguagem”, e propor uma maneira coerente de abordar a pesquisa linguística sem a fragmentação causada pela diversidade dos objetos constituídos pelos linguistas e pelas escolas linguísticas. Nenhuma nova teoria positiva do conjunto da linguagem poderia superar esta desintegração. Os esforços de Coseriu para ampliar o escopo para incluir os fatos linguísticos devem ser submetidos a uma radical reflexão cética sobre a possibilidade desta teoria positiva geral, baseada no fato de que o “falar concreto” não é o mero uso de um sistema virtual, mas uma criação contínua de sentido por indivíduos, e no fato de que a linguística em si é este “falar concreto”: individual, histórica, difusa. Coseriu não apresentou nenhuma teoria geral da linguagem, mas foi o exemplo vivo de uma personalidade individual rica e abrangente, que abordou a linguagem a partir de uma atitude crítica em relação às categorias e aos métodos herdados.
uma metaficção historiográfica dos contatos linguísticos na formação do português do Brasil
Authors: Baldoino Silva Jacson
Published: July 2023

A metaficção historiográfica (HUTCHEON, 1991) questiona a verdade colocada pela historiografia oficial e aponta que há verdades, contadas agora pela voz daqueles personagens apagados e silenciados pelas histórias oficiais. Nessa perspectiva, este artigo se propõe, como um desdobramento da teoria da metaficção historiográfica (HUTCHEON, 1991) e fundamentado nas teorias (socio)linguísticas (MATTOS E SILVA, 2004; LUCCHESI, 2009, 2017, 2019; CALLOU; LUCCHESI, 2020; LUCCHESI; CALLOU, 2020), a analisar o romance Um defeito de cor, da mineira Ana Maria Gonçalves (2021[2006]), como uma metaficção historiográfica dos contatos linguísticos ocorridos na formação do Brasil e, consequentemente, do português brasileiro. Essa proposta demonstra a necessidade de uma intersecção entre a Literatura e as Teorias Linguísticas, pois as narrativas ficcionais podem ser utilizadas como um suporte para as discussões, nos cursos de Letras/Português, sobre os contextos sócio-históricos de formação do português brasileiro, considerando, principalmente, a ausência de boas produções cinematográficas que ilustrem esse período.
Relações entre os aspectos do custeio alvo e o porte empresarial: um estudo no polo industrial de confecções de Santa Cruz do Capibaribe-PE
Authors: Sá Célio Beserra de , Callado Antônio André Cunha
Published: July 2023

Objetivo: Este artigo teve como objetivo investigar as relações entre aspectos do processo do custeio alvo e o porte empresarial, no âmbito de empresas do setor de confecções do polo industrial de Santa Cruz do Capibaribe-PE.
Metodologia: O estudo foi realizado por meio de uma pesquisa exploratória, descritiva e quantitativa, com envio de um questionário estruturado para as 110 indústrias de confecções cadastradas na base de dados da Federação das Indústrias do Estado de Pernambuco (FIEPE), conseguindo-se uma taxa de resposta de 21,82%. Para analisar as relações foi utilizado o teste estatístico não-paramétrico de Kruskall-Wallis, considerando-se um nível de significância na ordem de 95% (p=0,05).
Resultados: Com base nos aspectos metodológicos empregados, os principais resultados da pesquisa permitiram concluir que a utilização dos aspectos relativos à fase de planejamento do processo do custeio alvo é influenciada pelo porte das empresas analisadas. Por outro lado, a utilização dos aspectos da fase de desenho e da fase de produção não se mostrou influenciada pelo porte empresarial.
Contribuições do Estudo: A realização deste estudo contribui com a literatura especializada sobre a contabilidade gerencial, sobretudo no contexto brasileiro, uma vez que, o custeio alvo ainda é um artefato pouco explorado nas publicações nacionais. Outra contribuição à literatura diz respeito ao método utilizado, que permeou em uma abordagem quantitativa, ao passo que a maioria das pesquisas que abordam o custeio alvo são desenvolvidas por meio de estudos de caso. Ademais, a pesquisa também contribui com as empresas analisadas, apresentando-lhes um artefato gerencial útil em ambientes competitivos, o que pode influenciar na sua adoção.
Qualidade de vida no trabalho dos contadores em home-office durante a pandemia da Covid-19
Authors: Lizote Suzete Antonieta , Fontana Nathalie Moreira , Callegari Patrícia Taís , Silva Fernando Clementz da
Published: July 2023

Objetivo: Este estudo teve como objetivo identificar a percepção dos contadores sobre a qualidade de vida no trabalho em home-office durante a pandemia da Covid-19. Estudos sobre a qualidade de vida no trabalho são relevantes para se entender as variáveis que exercem impacto sobre o desempenho, tanto da organização, quanto de seus funcionários.
Metodologia: A pesquisa de natureza descritiva, teve abordagem quantitativa, sendo aplicado um questionário de autopreenchimento que destaca a qualidade de vida no trabalho (QVT) segundo modelo de Hackman e Oldham (1975), em três dimensões: tarefas executadas no trabalho, sentimento pessoal a respeito do trabalho e satisfação com os aspetos do trabalho. Os respondentes foram 132 contadores que estavam em home office em empresas de serviços contábeis localizadas no Estado de Santa Catarina. Os dados foram analisados descritivamente com base na frequência das respostas.
Resultados: Os resultados revelaram, de forma geral, uma QVT para os contadores pesquisados. A analisar as dimensões, se observa que, em relação as tarefas executadas no trabalho, destacou-se aquela em que os superiores frequentemente dizem o que pensam da qualidade do trabalho desenvolvido. No que tange as asseverações relacionadas ao sentimento pessoal a respeito do trabalho, se sobressaiu: penso frequentemente em largar este trabalho. Por fim, sobre a satisfação com os aspectos do trabalho, a segurança, em termos físicos e mentais, no trabalho realizado foi a que obteve maior média entre os respondentes.
Contribuições do Estudo: Os achados deste estudo oferecem um breve diagnóstico de indicadores psicossociais da realidade dos profissionais da área contábil e pode sustentar futuras reflexões e discussões sobre a continuidade e o aprimoramento do home-office no âmbito das empresas de serviços contábeis, bem como, conhecer o que pensam os funcionários de empresas de serviços contábeis sobre QVT são pressupostos essenciais a concepção de políticas e programas de gestão de recursos humanos.
Análise metodológica dos EBITDA incompatíveis divulgados pelas companhias listadas na B3: identificação das variáveis divergentes nas conciliações
Authors: Kistner Shaiane Pisa , Platt  Neto Orion Augusto
Published: July 2023

Objetivo: Identificar as variáveis responsáveis pelas divergências metodológicas causadoras de incompatibilidades nos EBITDA divulgados pelas companhias listadas na B3, relacionadas a erros na coleta de dados e a alterações indevidas na fórmula por parte das entidades emitentes da conciliação.
Metodologia: Aplicação de estatística descritiva sobre uma amostra de 35 entidades que divulgaram o EBITDA incompatível referente a 2018, observando o comportamento das variáveis do indicador nos anos de 2018, 2019 e 2020.
Resultados: Os erros de apuração mais comuns se deram na coleta de dados junto às demonstrações contábeis. A variável que mais impactou nos valores apurados erroneamente foi relativa à depreciação, amortização e exaustão. Conclui-se que, mesmo com a normatização da evidenciação do EBITDA pela Comissão de Valores Mobiliários a partir de 2012, ainda são comuns erros de apuração desse indicador, o que reforça a necessidade de estudos práticos que verifiquem a conformidade dessas divulgações não GAAP das companhias.
Contribuições do Estudo: Considerando que medidas de desempenho não GAAP, como o EBITDA, são difundidos mundialmente junto a investidores e analistas para a análise dos resultados das empresas, tais medidas guardam o risco de sofrer com erros e manipulações por parte dos gestores das entidades emitentes. Neste sentido, o estudo contribuiu no âmbito prático pois demonstrou quais erros as companhias efetivamente cometeram ao apurar e demonstrar suas conciliações de EBITDA. Ainda, supre lacuna acadêmica referente à metodologia de apuração do EBITDA, já que mesmo com a literatura crescente relacionada às divulgações não GAAP, a forma de cálculo do indicador tem recebido pouca atenção.
Ethical behavior in the work environment and its effects on academic misconduct
Authors: Anzilago Marcielle , Daciê Franciele do Prado , Giustina Kelly Arent Della
Published: July 2023

Objective: This study aims to analyze the effects that ethical behavior in the work environment has on attitudes towards cheating in the academic environment among accounting sciences students.

Methodology: A survey was carried out with students from a public HEI, totaling 140 participants. For data analysis, structural equations and factorial analysis were used as technique.

Results: The findings show that, in addition to ethical behavior in the workplace, there are other variables that lead students to have academically dishonest attitudes. In this way, ethical behavior influences the unethical behavior of accounting students at the HEI studied, and, although with still small effects, the experiences lived and taken as ethical in the professional environment tend to be related to an evasion of dishonest attitudes in the academic sphere, that is, a better corporate ethical rank results in a smaller presence of cheating behaviors in academia.

Study Contributions: The study contributes to reflection on the improvement of students' behavior in the work environment and how this affects the academy, showing the importance of discussing ethics in professional and educational environments. It reveals the importance of ethics not only in the academic environment, but also in the business environment, so that there is a convergence between both.
Exploring the Mechanism of Si-miao-yong-an Decoction in the Treatment of Coronary Heart Disease based on Network Pharmacology and
Experimental Verification
Authors: Zhang Jingmei , Xue Siming , Chen Huan , Jiang Haixu , Gao Pengrong , Lu Linghui , Wang Qiyan
Published: July 2023

Background:

To investigate the active ingredients and the mechanisms of Si-miaoyong-
an Decoction (SMYA) in the treatment of coronary heart disease (CHD) by using network
pharmacology, molecular docking technology, and in vitro validation.

Methods:

Through the Chinese Medicine System Pharmacology Database and Analysis Platform
(TCMSP), Uniprot database, GeneCards database, and DAVID database, we explored the core
compounds, core targets and signal pathways of the effective compounds of SMYA in the treatment
of CHD. Molecular docking technology was applied to evaluate the interactions between active
compounds and key targets. The hypoxia-reoxygenation H9C2 cell model was applied to carry
out in vitro verification experiments. A total of 109 active ingredients and 242 potential targets
were screened from SMYA. A total of 1491 CHD-related targets were retrieved through the Gene-
Cards database and 155 overlapping CHD-related SMYA targets were obtained. PPI network topology
analysis indicated that the core targets of SMYA in the treatment of CHD include interleukin-
6 (IL-6), tumor suppressor gene (TP53), tumor necrosis factor (TNF), vascular endothelial
growth factor A (VEGFA), phosphorylated protein kinase (AKT1) and mitogen-activated protein
kinase (MAPK). KEGG enrichment analysis demonstrated that SMYA could regulate Pathways in
cancer, phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling pathway, hypoxiainducible
factor-1(HIF-1) signaling pathway, VEGF signaling pathway, etc.

Results:

Molecular docking showed that quercetin had a significant binding activity with VEGFA
and AKT1. In vitro studies verified that quercetin, the major effective component of SMYA, has a
protective effect on the cell injury model of cardiomyocytes, partially by up-regulating expressions
of phosphorylated AKT1 and VEGFA.

Conclusion:

SMYA has multiple components and treats CHD by acting on multiple targets. Quercetin
is one of its key ingredients and may protect against CHD by regulating AKT/VEGFA pathway.
The Effect of Dexamethasone on Lipopolysaccharide-induced Inflammation
of Endothelial Cells of the Blood-brain Barrier/Brain Capillaries
Authors: Jeftha Tershlin , Makhathini Khayelihle Brian , Fisher David
Published: July 2023

Background:

A protective and regulatory barrier between the blood and the brain is
constituted by the blood-brain barrier (BBB), which comprises microvascular endothelial cells
providing homeostatic regulation of the central nervous system (CNS). Inflammation compromises
the BBB and contributes to many CNS disorders. Anti-inflammatory effects are exerted by glucocorticoids
(GCs) on a variety of cells. These GCs include dexamethasone (Dex), which is used for
the treatment of inflammatory diseases and recently for the treatment of COVID-19.

Aim:

The purpose of this study was to determine whether low or high concentrations of Dex can attenuate
the inflammatory response induced by lipopolysaccharide (LPS) in the in vitro BBB model.

Methods:

Brain endothelial cells (bEnd.5) were cultured and exposed to LPS (100ng/ml) and subsequently
co-treated with Dex to investigate whether selected concentrations of Dex (0.1, 5, 10,
20μM) can modulate the inflammatory effects of LPS on bEnd.5 cells. Cell viability, cell toxicity,
and cell proliferation were investigated, as well as the monitoring of membrane permeability (Trans
Endothelial Electrical Resistance-TEER), and Enzyme-Linked Immune Assay (ELISA) kits were
used to identify and quantify the presence of inflammatory cytokines (TNF-α and IL-1β).

Results:

Dex, at a lower dosage (0.1μM, but not higher doses), was able to attenuate the inflammatory
effects of LPS on bEnd.5 cells. Lower doses of Dex (0.1μM) had no detrimental effects on
bEnd.5 cells, while higher Dex doses (5-20μM) decreased bEnd.5 viability, increased bEnd.5 cell
toxicity, increased bEnd.5 cell monolayer permeability, and increased proinflammatory cytokine
secretion.

Conclusion:

These results indicate that treatment of brain vascular inflammation with low doses of
Dex should be advocated, while higher doses promote vascular inflammation.
An empirical study of extracting embedded text from digital images
Authors: Shafie Emad
Published: July 2023

The utilization of images as a means of transferring information is a widespread technique employed to circumvent simple detection functions that primarily focus on analyzing textual content rather than conducting thorough file examinations. This study investigates the efficacy of deep learning models in detecting embedded information within digital images. The data used for analysis was acquired from a secondary source and underwent comprehensive preprocessing. Feature extraction, sequence labeling, and predictive model training were performed using CRNN, CNN, and RNN models. Two specific models were trained and tested in this research: 1) CNN, RNN-LSTM with the Adam optimizer, and 2) CNN, RNN-GRU with the RAdam optimizer for text detection. The findings reveal that Model #1 achieved the highest F1-score during testing, with a score of 98.37% for text detection and 96.73% for word detection. The second model obtained an F1-score of 94.84% and 93.05% for text and word detection, respectively. Model #1 exhibited a word detection accuracy of 98.38% and a text detection accuracy of 96.47%. These findings indicate that the first model outperformed the second model, suggesting that employing RNN-LSTM and the Adam optimizer made a positive impact. Therefore, utilizing deep learning tools and emerging technologies is crucial for extracting textual information and analyzing visual data. In summary, this study concludes that deep learning models can be relied upon to effectively detect textual information embedded within digital images.
Effect of gibberellic acid on germination and seedling growth of Soybean (Glycine max L. Merrill)
Authors: Mohammed Abdullah
Published: July 2023

The germination percentage of Soybeans is susceptible and affected by many external and internal factors. Screening of three varieties of soybeans (Shimaa, Industrial2, and M103) during laboratory germination and field emergence was conducted to identify varieties with superior performance under four concentrations of gibberellic acid (0, 75, 150, 225 ppm). Experiments were conducted in Field Crops Dept./College of Agriculture/Tikrit University. Results showed significant differences between gibberellic acid concentrations, varieties, and interactions for all studied traits. Seeds treated with a concentration of (150 ppm) were superior in laboratory germination and field emergence percentages, averaging 92.58% and 59.08%, respectively. Varieties of Shimaa and M103 were superior in giving the highest germination percentage in the laboratory, 87.5% and 87.94%, respectively. The Shimaa variety outperformed, giving the highest field emergence percentage, 58.00%. Interaction of Shaima x150 ppm (GA3) showed the highest laboratory germination percentage and highest field emergence percentage, 96.75% and 63.25%, respectively. These Results indicate that the use of gibberellic acid significantly increased the germination rate of soybean seeds and field emergence rate due to the role of this hormone in stimulating the synthesis of enzymes necessary for germination and seedling vigor.

Keywords: Soybean; GA3; Seed germination percentage; Field emergence percentage.
Plants anatomically engineered by nanomaterials
Authors: Abdul-Rahman Owied Osama , Muslim Guda Muthik Abd , Imad Taher Hawraa , Ali Abdulhussein Muslim Abd
Published: July 2023

Anatomical characteristics are essential in determining the stress that affects plants. In addition, they provided a piece of evidence for environmental pollution. The increasing use of nanomaterials (EnNos) in industries, medicine, agriculture, and all fields. Nanomaterials also have many uses as a new science; they have toxic effects that have not been studied well. Therefore, this research was interested in recording recent studies on (EnNos) and their impact on the anatomical characteristics of plants.

Moreover, the possibility of using anatomical characteristics as evidence of nano contamination (nanotoxicity) in plants comprises a crucial living component of the ecosystem. Studies on the effect of EnNos (carbon) on plant anatomy indicated that excess EnNos content affects the anatomical structure of the plant from the vital structures of the root, stem and leaves. Toxicological effect on xylem and phylum vessels from toxicological studies to date, Toxicological effects on EnNos of various kinds can be toxic if they are not bound to a substrate or freely circulating in living systems. Different types of EnNos, behavior, and plant capacity generate different paths. Moreover, different, or even conflicting, conclusions have been drawn from most studies on the interactions of EnNos with plants. Therefore, this paper comprehensively reviews studies on different types of carbon EnNos and their interactions with different plant species at the anatomical responses.

Keywords: Anatomical characteristics, nanomaterials, nanotoxicity, Fullerene and Carbon Nanotubes