bluuebunny/crossref_metadata_2025 huggingface dataset:
Major Cardoso e João Ternura
Authors: Teixeira Marcos Vinícius
Published: March 2020

Resumo: Apesar de se tratar de um texto não aproveitado na versão final do romance João Ternura, “O homem e seu capote”, de Aníbal Machado, pode ser lido e estudado de forma independente como um conto. O episódio protagonizado por João Ternura se assemelha a determinadas cenas que o major Cardoso vive na novela coletiva O capote do guarda, da qual participou o próprio Aníbal Machado no início dos anos 1920. No entanto, esta novela permaneceu inacessível aos leitores durante muito tempo, tendo sido reeditada somente nos anos de 2005 e 2006. É possível supor que esta obra tenha sido uma fonte motivadora para a realização de “O homem e seu capote”, o que ainda não foi investigado pela crítica literária. Nessa perspectiva, o objetivo deste artigo é estudar este conto em relação à referida novela, considerando-se o capote e as ocorrências ligadas a esse elemento nas duas narrativas. Espera-se contribuir para uma melhor compreensão do universo literário do escritor, especialmente em relação ao período que antecede a publicação de seu primeiro livro.
Palavras-chave: Modernismo brasileiro; Aníbal Machado; Major Cardoso; João Ternura.
Vazio, evasão (uma leitura de João Gilberto Noll)
Authors: Da Rosa Victor
Published: March 2020

Resumo: O artigo indaga a literatura de João Gilberto Noll a partir de uma dinâmica entre as figuras do vazio e da evasão, que permeiam alguns dos principais debates em torno da literatura do autor desde os anos 1980, de Silviano Santiago a Reinaldo Laddaga, mas que se procura reinterpretar a partir de um diálogo com o pensamento de Jacques Rancière e Georges Didi-Huberman, assim como da leitura que Deleuze e Guattari realizam da obra de Kafka. Nesse sentido, analisa-se a maneira como três das principais chaves de leitura da obra de Noll – corpo, voz e território – se articulam e desarticulam por meio de um sintoma específico, o de orfandade, que expõe seus primeiros sinais, não por acaso, no conto inaugural do autor, “Alguma coisa urgentemente”.
Palavras-chave: evasão; letra órfã; animalidade; abandono; João Gilberto Noll.
“Cuidado, leitor, ao voltar esta página!”, sobre prefácios, leitores e escritores no Romantismo brasileiro
Authors: Amparo Flávia Vieira da Silva do , Silva Mônica Gomes da
Published: March 2020

Resumo: Este artigo objetiva identificar e refletir sobre as estratégias discursivas utilizadas nos prefácios de obras que participam da consolidação do sistema literário brasileiro no século XIX: Primeiros cantos, Lira dos vinte anos, A moreninha e Ressurreição. Busca-se estudar as imagens construídas acerca do Leitor, do Autor e da Obra nos textos introdutórios de Gonçalves Dias, Álvares de Azevedo, Joaquim Manuel de Macedo e Machado de Assis. Parte-se da concepção de paratexto desenvolvida por Gérard Genette (2009) que destaca, especialmente, o aspecto intersticial do prefácio, além do cotejo com dois grandes modelos de prefácio para o Romantismo brasileiro: o Prólogo da Primeira Parte de O engenhoso fidalgo Dom Quixote de La Mancha, de Miguel de Cervantes, e Prefácio ao Cromwell, de Victor Hugo. Ao reafirmar a condição de antessala da obra literária, o prefácio é entendido como um limiar entre realidade e ficção que, para além da função circunstancial e pragmática de apresentação do texto, possibilita a criação de uma verdadeira mise-en-scène discursiva. Nesse sentido, aprecia-se como os autores brasileiros, num contexto literário julgado incipiente, constroem os princípios de um “como e por que ler” indispensáveis à formação de um público-leitor.
Palavras-chave: paratexto; prefácio; Romantismo.
Além do livro
Authors: Mattar Marina Ribeiro
Published: March 2020

Resumo: Este artigo objetiva investigar o livro-objeto Poemóbiles, de Augusto de Campos e Julio Plaza, dando enfoque ao seu modo de produção – enquanto criação – e seus produtos de transcriação ou tradução criativa. Por meio do conceito de transcriação de Haroldo de Campos e desdobramentos das teorias de tradução de Jakobson na teoria de transposição semiótica de Julio Plaza, sugeriu-se a leitura dos poemas VIVAVAIA e REVEЯ e demonstrou-se como eles materializam-se em diversas mídias e propostas de tradução, seja pelo próprio Augusto de Campos ou por outros artistas. Conclui-se que a tradução criativa atualiza o objeto poético de forma verbivocovisual e proporciona uma maior mobilização dos sentidos na apreensão das obras.
Palavras-chave: Poemóbiles; Augusto de Campos; transcriação.
livro brasileiro nos anos 1920
Authors: Martins Milena Ribeiro
Published: March 2020

Resumo: Este artigo analisa textos e paratextos da literatura brasileira da década de 1920 a fim de caracterizá-la como um momento de transformações determinantes para a história do livro brasileiro. Observa-se no período um processo de nacionalização da produção livreira, em consonância com uma progressiva nacionalização da linguagem e dos temas. Com o crescimento significativo do número de editores brasileiros atuando na publicação de literatura, tornaram-se mais estreitos os vínculos entre diferentes agentes do processo de produção, venda e recepção de livros, propiciando, como consequência, formas novas de profissionalização dos intelectuais. Casos como o dos escritores-editores Benjamin Costallat e Monteiro Lobato são apresentados e analisados, de forma a tornar mais compreensíveis algumas das ações colocadas em prática por eles. Para que tal análise seja possível, é necessário atentar para elementos paratextuais (prefácios, epígrafes, capas) presentes em edições antigas dos livros estudados, além de documentos pessoais. Dentre os livros mencionados, estão Urupês (1918), de Lobato; Histórias e sonhos (1920), de Lima Barreto; Fim (1921), de Medeiros e Albuquerque; Mademoiselle Cinema (1923), de Costallat; e Amar, Verbo intransitivo (1927), de Mário de Andrade. A atividade editorial é aqui compreendida como uma ação essencialmente plural, que envolve diversos agentes, dentre os quais os próprios escritores, que estão incluídos entre os responsáveis não apenas pelo texto, mas também por aspectos da materialidade dos livros. O sistema literário brasileiro conquistava sua independência e maturidade, ao passo que, por meio de dispositivos textuais e editoriais, formava-se um novo tipo de leitor.
Palavras-chave: história do livro; modernismo; editores.
Encontros e desencontros em “O menino”, de Lygia Fagundes Telles, e “Oval com pontas”, de Adriana Lisboa
Authors: Cruvinel Larissa Warzocha Fernandes , Ribeiro Renata Rocha
Published: March 2020

Resumo: O conto “O menino”, de Lygia Fagundes Telles, publicado inicialmente em O cacto vermelho, de 1949, narra a história de um menino que enfrenta um processo de amadurecimento durante um passeio que realiza com a mãe ao cinema. O conto “Oval com pontas”, de Adriana Lisboa, publicado originalmente em Contos que contam, de 2005, aproxima-se do conto de Telles ao também narrar o passeio de uma mãe com um filho, ambos inominados. Apesar da semelhança no enredo das narrativas, a prosa das duas escritoras apresenta divergências sobre a configuração das relações familiares e sobre o papel social da arte. Como considera José Paulo Paes (1998), a obra de Telles é marcada pelo desencontro nas mais diversas relações afetivas apresentadas nas tramas, o que, segundo o crítico, assinala certa desilusão dos escritores que viveram os traumas da Segunda Guerra Mundial. Em contrapartida, a obra de Lisboa frequentemente aposta na superação dos traumas das personagens retratadas, além de se contrapor ao esvaziamento do papel da arte na contemporaneidade. Tendo em vista esses apontamentos, este artigo tem como objetivo analisar o papel da arte e das relações humanas nos referidos contos. Para fundamentar criticamente a discussão, elegemos as contribuições de Coelho (1971), Lopes (2007), Paes (1998), entre outros.
Palavras-chave: conto brasileiro; encontros; desencontros; Lygia Fagundes Telles; Adriana Lisboa.
paisagem sonora como elemento constitutivo no conto “O poncho”, de Charles Kiefer
Authors: Debortolli Viviane Aparecida Pandolfo , Werlang Gérson Luís
Published: March 2020

Resumo: Este artigo se propõe a verificar os elementos constitutivos da paisagem sonora do conto “O poncho”, de Charles Kiefer. A presença da música, dos ventos, de sons naturais e não naturais se alinham ao clima da narrativa e compõe o cerne em que se desenvolve a narrativa. Neste conto, a paisagem sonora tem papel determinante no desenvolver do enredo, visto que influencia as ações do personagem. Levando-se em consideração as diferentes possibilidades de eixos de análise que o texto literário permite, pretende-se evidenciar a paisagem sonora como um elemento da narrativa por meio da presença dos sons na obra selecionada, e, através disso, demonstrar de que forma eles são relevantes na construção do enredo.
Palavras-chave: paisagem sonora; clima; narrativa.
Padre Hipólito e Padre Albano
Authors: Saraiva Vandemberg Simão
Published: March 2020

Resumo: Este artigo intenta analisar, por meio de contrapontos, os sacerdotes católicos da novela Roque Santeiro, adaptação televisiva da peça O berço do herói, de Dias Gomes (1922-1999). A fim de subtrair-se à censura reinante no regime militar, o texto mencionado passou por modificações e situações outras que provocaram o surgimento de uma obra de autoria coletiva. Os presbíteros passaram a integrar uma nova trama, em que duas maneiras de ser Igreja se contrapõem: o viés tradicionalista e a visão baseada nos pressupostos da Teologia da Libertação. Padre Hipólito representa o catolicismo tradicionalista, já Padre Albano é partidário de uma Igreja mais engajada socialmente, por isso é chamado de “padre vermelho”. Por meio dessas personagens, a novela abordou, de forma geral, essas duas maneiras de vivenciar a fé católica.
Palavras-chave: O berço do herói; telenovela Roque Santeiro; adaptação televisiva; Igreja Católica; Teologia da Libertação.
Escrever a alteridade, inscrever o animal
Authors: Gimbo Fernando Sepe
Published: March 2020

Resumo: Trata-se de apresentar a questão ético-política que o problema da alteridade animal coloca através de uma articulação entre filosofia e literatura. Para tanto, primeiramente exponho uma leitura parcial sobre as diversas conferências dadas por Jacques Derrida em torno do assunto. Conferências essas reunidas sobre o título “O animal que logo sou”, verdadeiro ensaio para uma filosofia futura capaz de (re)escrever a animalidade a partir da tradição filosófica. Nesta releitura, proponho que o principal resultado do texto derridiano é uma recolocação da questão ética da violência sobre o outro, assim como uma reflexão política sobre o caráter antropocêntrico da modernidade. Feito isso, passo para uma análise de um conto de Clarice Lispector intitulado “O crime do professor de matemática”. Conto que compõe a coletânea Laços de Família e que consiste em um agudo relato sobre a relação entre o homem e o animal. Mais do que um simples exercício de exemplificação, trata-se de pensar com a literatura um tema que, historicamente, fora enclausurado pelo discurso filosófico no dualismo próprio ao que Derrida chama de “tradição do cogito”.
Palavras-chaves: Derrida; Lispector; animal studies; humanismo; desconstrução.
trilogia fonsequiana da fragilíssima virilidade
Authors: Ferreira Júnior Nelson Eliezer
Published: March 2020

Resumo: Esse artigo tem como objetivo o estudo das marcas da virilidade nos contos “Fevereiro ou março”, “A força humana” e “O desempenho”, de Rubem Fonseca, publicados nos três primeiros livros de contos do autor, na década de 1960. Na análise dessa trilogia, recorreu-se a teóricos sobre masculinidade e virilidade, tais como Bourdieu (1999), Machado (2004) e Courtine (2013), para investigar como esses aspectos estão presentes nas narrativas. Constatou-se que, nos contos, os signos de virilidade estão atrelados a processos de identificação, estilização e crenças, estando todos impregnados por marcas de ironia constituídas pelo paradoxo potência/impotência, especialmente no âmbito do protagonista. Ao final, conclui-se que a abordagem de obra de Rubem Fonseca sob essa perspectiva tem se mostrado promissora e que a discussão acadêmica da virilidade é uma necessidade política na atualidade.
Palavras-chave: Rubem Fonseca; conto; virilidade; fragilidade.
DETERMINATION OF THE EFFECT OF ENERGY CONSUMPTION ON ECONOMIC GROWTH IN CENTRAL ASIAN TURKISH REPUBLICS
Authors: ÇEMREK Fatih
Published: March 2020

Energy plays an important role in the economic growth, social development and individuals’ prosperity and comfort of countries. The effect of energy consumption on economic growth depends on the economic structure of the country.
In this study, per capita electricity consumption (kwh) and Gross Domestic Product ($) per capita for the period covering 1991-2014 for six countries in Central Asia (Azerbaijan, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) panel data analysis was used to investigate the relationship between the series. According to the results, the existence of the cointegration relationship among the variables discussed in the examined countries was determined.
CUDA Based Computation of Quadratic Image Filters
Authors: Akgün Devrim , Uzun Süleyman
Published: March 2020

Image processing applications usually requires nonlinear methods due to the nonlinear characteristics of images. Quadratic image filter which is a class of nonlinear image filters are widely used in practice such as noise elimination edge detection and image enhancement. On the other hand, second order products of the pixels make quadratic image filters computationally expensive to implement when compared to linear convolution. In the last decade, CUDA accelerated computing has been widely used in image processing applications to reduce computation times. In this study, an efficient method for the CUDA acceleration of the quadratic image filter has been implemented. For this purpose, alternative algorithms were examined comparatively since the performance of the GPU is sensitive to memory utilization. Because quadratic filter has a large number of coefficients and quadratic terms, the algorithm which utilizes the shared memory for storing image blocks provided the best throughput among the examined methods. Comparative results that were obtained using various images in different sizes show significant accelerations over sequential implementation.
An Ensemble Classifier for Finger Movement Recognition using EMG Signals
Authors: Özkan İlker Ali
Published: March 2020

Electromyography
(EMG) signals that obtained by electrodes connected to the forearm are the
monitoring of the muscles by the electrical method. These signals are quite
useful during the use of prosthesis as a source signal to the moving prosthesis.
Therefore, it is essential that classifying the EMG signals with high accuracy
by analyzing. This study aims that classifying the individual and combined
finger movements using surface EMG signals taken from the surface of the human
forearm. EMG signals that belong to 10 different finger movements obtained from
eight subjects were used. Firstly, EMG signals have been split into segments by
the windowing process, and temporal feature vectors are formed by applying
various feature extraction methods to these segments.  Feature vectors have been classified with the
ensemble bagged tree algorithm, which is a combination of classifiers, to
obtain the correct classification decision. As a result of 10-fold
cross-validation, with the proposed method, 96.6% overall classification
accuracy was achieved. The results obtained show that the ensemble classifier
can be used successfully in determining finger movements when compared with
similar studies.
INVESTIGATION OF MODIFIED EJECTOR CYCLE ON RESIDENTIAL AIR CONDITIONER WITH ENVIRONMENTALLY BENIGN REFRIGERANT OF R290
Authors: SUMERU Kasni , SUKRİ Mohamad Firdaus , PRATİKTO Pratikto , BADARUDİN Apip
Published: March 2020

This paper investigates a modified ejector cycle (MEC) to further enhance the COP improvement of residential air conditioner (A/C), as compared to the standard ejector cycle (SEC). This paper also presents numerical and experimental studies of the MEC. Numerical approach of MEC performances was evaluated by using SEC cycle that had been developed by many researchers. In the experimental study of MEC, three motive nozzle diameters of 0.9, 1.0 and 1.1 mm were utilized. In addition, environmentally friendly refrigerant of R290 (propane) was used as a working fluid. The modeling results of residential A/C with the cooling capacity of 2.5 kW showed higher COP improvements of MEC than SEC for all entrainment ratios of the ejector. There was no COP improvement for SEC at a low entrainment ratio, whereas there are always COP improvements for all entrainment ratios for MEC. In addition, the experimental results showed the highest COP improvement of 16.67% was achieved with the motive nozzle diameter of 1.1 mm.
A influência do contexto na incorporação de estratégias sustentáveis em hotéis
Authors: Adams Bruna , Mulazzani Doleys Soares Roberta , Soares Vieira Myrella
Published: March 2020

O crescente investimento do setor hoteleiro em certificações de sustentabilidade evidencia os benefícios proporcionados tanto para o empreendimento, como para os hóspedes e o contexto no qual o hotel está inserido. Pois, além de contribuir para um meio ambiente mais saudável, torna-se um diferencial competitivo para os hotéis e atrai novos hóspedes que compartilham com esta preocupação ambiental (turismo sustentável). Porém, muitas vezes, o uso de estratégias sustentáveis está vinculado aos hotéis em um contexto mais rural. Desta forma, buscou-se analisar a aplicação de estratégias sustentáveis no ramo hoteleiro em dois estudos de caso com características e contextos opostos, estudando ambas as situações e visando a pesquisa e o incentivo da inserção de estratégias sustentáveis ao projeto de hotéis. Para isso, são apresentados dois hotéis que incorporaram a sustentabilidade desde o projeto até o funcionamento diário. Trata-se do Cambará Eco Hotel localizado em Cambará do Sul–RS, sendo um estudo de caso desenvolvido in loco e o Venit Mio Barra Hotel localizado na Barra da Tijuca-RJ, compreendendo uma pesquisa bibliográfica. O Cambará Eco Hotel encontra-se relativamente afastado da cidade, possui uma grande área destinada à prática de caminhadas em meio à vegetação nativa preservada e possui certificação da NBR 15401(2014). Em contrapartida, o Venit Mio Barra Hotel está locado em meio à intensa urbanização, possui certificação Procel e incorpora duas tipologias hoteleiras em seu programa, a ala de negócios (curta estadia) associada à agitação do dia a dia e o setor voltado aos hóspedes que buscam tranquilidade, contando com vista para a Lagoa de Marapendi. Como pesquisa complementar, é apresentado um hotel na Alemanha, vencedor de um concurso, também implantado em um contexto urbano, de forma a verificar as estratégias empregadas e estabelecer um comparativo com os exemplos nacionais. Os estudos revelaram que ambos os hotéis são reconhecidos pelas práticas sustentáveis, evidenciando que aplicar a arquitetura sustentável contribui com resultados positivos independente do contexto no qual for implantada.
Noções de Urbano: uma construção da memória (e da cidade) de Itaboraí – RJ
Authors: Oliveira Souza Pâmella Victória , Polito Jéssica De Almeida
Published: March 2020

Ao observar que as obras humanas inscrevem e imprimem no território característica únicas, propõe-se compreender a cidade de Itaboraí enquanto fragmento da paisagem cultural do Rio de Janeiro. A formação dessa cidade, de origem colonial, ocorreu pela instalação de uma grande praça, mais conhecida como largo da Matriz. Hoje, ao redor deste largo denominado “Praça Marechal Floriano Peixoto”, encontra-se um rico conjunto arquitetônico e patrimonial que consolida o Centro Histórico. Tal qual o trabalho do arqueólogo, pode-se desvendar nesta centralidade camadas e sobreposições históricas capazes de resgatar o processo de desenvolvimento da cidade, da memória urbana e dos valores simbólicos atribuídos pelos seus habitantes ao longo do tempo. Desta maneira, a pesquisa procura recuperar a importância da educação patrimonial e urbanística para o contínuo desenvolvimento dessa cidade enquanto sítio histórico e paisagem cultural.
Verificação da influência da geometria do forro na qualidade acústica do Cine teatro Luz de União da Vitória – PR
Authors: Meyer Edwin Cassio , Oliveira Maria Fernanda de , Heissler Rafael Ferreira
Published: March 2020

O presente estudo busca entender, principalmente, a interferência que a geometria do forro do Cine Teatro Luz, localizado na cidade de União da Vitória no Paraná, tem na qualidade acústica, considerando essa geometria incomum nos aspectos relacionados à distribuição sonora, por conta do posicionamento da sua curvatura. O Cine Teatro Luz é um edifício tombado pelo estado como patrimônio e, atualmente, está em processo de restauro. O objetivo deste trabalho consiste em esclarecer qual a influência que o forro original tem sobre a qualidade acústica da sala do Cine Teatro Luz, utilizando os parâmetros acústicos TR, EDT, D50, C80 e STI, em que os resultados desses parâmetros são comparados aos resultados de uma modelagem com uma proposta de forro que proporciona distribuição sonora mais convencional. O método consistiu em utilizar as informações da sala na modelagem computacional, com duas situações de forro: a primeira com o forro original, com curvas longitudinais à sala e, a segunda modelagem, chamada de forro proposto com curvas transversais à sala. Ambas as modelagens foram simuladas no software acústico CATT-acoustic v9.1b – demo version, com dados de entrada dos coeficientes de absorção (α) e dos coeficientes de espalhamento (s), assim como dados de entrada para fonte sonora e posição de receptores. Durante a análise comparativa entre os resultados das modelagens, observou-se a influência de cada forro nos resultados. Pode-se concluir que os resultados apresentados na modelagem com o forro proposto, contribuíram na melhora da qualidade acústica da sala, considerando que a sala é destinada ao multiuso. No entanto, os resultados mostraram que a geometria do forro original pode beneficiar as atividades voltadas à música.
Análisis de la política energética a partir del cumplimiento de la reducción de emisiones de dióxido de carbono (CO2) entre países de América latina con economía extractivista
Authors: Pinilla Rivera Maribel , De Corso Sicilia Giuseppe Bernardo
Published: March 2020

El artículo de investigación presenta un análisis de la política energética a partir del cumplimiento del Protocolo de Kioto en 1997, referente a la reducción de emisiones de dióxido de carbono (CO2) entre los países con economía extractiva más representativos de América Latina, cuya transformación puede explicarse tanto por las dinámicas de cada país con sus instituciones, como por el resultado de situaciones de cambio potencial. El apoyo documental de la investigación se realizó mediante recursos de análisis de tipo cualitativo y cuantitativo, donde se evidencian el comportamiento de las tasas promedio de emisiones, las emisiones por unidad de producción económica y la demanda de energía por fuente en América Latina. De acuerdo con los resultados se evidencian empíricamente que la hipótesis de la curva de Kuznets no se cumple por tanto no puede considerarse que el rápido crecimiento económico solucionara, eventualmente, los problemas ambientales. Asimismo se evidencia el elevado ritmo de crecimiento económico en el largo plazo en América Latina lo que hace necesario disponer de una matriz energética diversificada, eficiente, con costos competitivos y donde las energías renovables tengan un papel relevante y así disminuir la deficiencia de la política energética.
Chemical Composition and Bioefficacy of Essential Oil from Bay Laurel Shrub (Laurales: Lauraceae) against Culiseta longiareolata (Macquart) (Diptera: Culicidae) Larvae
Authors: Bouzidi Oulfa , Tine Samir , Hamaidia Kaouther , Tine-Djebbar Fouzia , Soltani Noureddine
Published: March 2020

An essential oil extracted from bay laurel, Laurus nobilis (L.), was chemically characterized and tested against fourth-instar Culiseta longiareolata (Macquart) (Diptera: Culicidae). Percentage composition of the oil in L. nobilis was 0.96, and gas chromatography–mass spectrometry analysis identified 56 components with eucalyptol (25.62%), linalool (11.83%), methyl eugenol (10.07%), and camphene (10.18%) as the major constituents. Laboratory bioassays demonstrated significant larvicidal activity of the oil extract with cumulative median lethal concentrations (i.e., LC50) of 203.7 parts per million (ppm) at Day 1, 171.9 ppm at Day 3, and 85.1 ppm at Day 7 after exposure. The essential oil also affected egg hatch and sex ratio of the progeny. These results suggest that the essential oil extracted from L. nobilis has potential for development as a management tactic directed against Cs. longiareolata.
Actinomycetes Isolation from Forest Soils and Determination of Biological Activities
Authors: SOYER Pervin , TUNALI Yağmur
Published: March 2020

Actinomycetes bacterial group has the one of the most populous population in microorganisms that extends very different and extensive habitats on earth especially main character of the natural soil habitats. Since old times, bioactive metabolites of soil microorganisms have studied and the results have provided that metabolites these microorganisms have significant benefits to science, medicine, agriculture and pharmaceutical industry. In this study, isolation of Actinomycetes strains from forest soils, identification of morpohological and molecular features, extraction the bioactive metabolite of isolates and determination the antimicrobial, antibiofilm and cytotoxicity activities of bioactive extract was tested. The microbiological isolation methods for collected forest soil samples were used and after the determination of their morphological and molecular features, isolates were defined as Brevibacterium spp. that is member of Actinomycetes. The antibiotic resistance of the isolates were determined by different methods and different concentrations of standard antibiotics. The chromium tolerance of isolates were also determined. The bioactive metabolites of isolates were produced in modified medium and extracted. The antimicrobial, antibiofilm, cytotoxicity activities of bioactive metabolite were determined against standard microorganisms and Artemia salina larvae were used as test organism for cytotoxicity tests. In the present study, results gave informations about Actinomycetes that isolated from forest soils. Isolates have antibiotic resistance and chromium tolerance abilities. And also, showed, Actinomycetes group is the largest bioactive metabolite producing group both antibacterial, antifungal and also a wide range of other compounds such as antibiofilm and cytotoxic compounds. The antimicrobial (MIC) concentrations of bioactive metabolite 2500 μg/mL for standard bacteria cultures and 1250 μg/mL for yeasts. The antibiofilm (MBEC) value was determined at 1250 μg/mL. The 2500 μg/mL concentration of extract was found the effective cytotoxic value. The results are provided that the Brevibacterium spp. isolates have industrial and pharmaceutical potential and more detailed pharmaceutical researchs are planned.
Russian healthcare in the context of achieving universal access to health services by 2030
Authors: Katkova Irina P.
Published: March 2020

The article presents the results of an analysis of data from global monitoring systems and international studies for the period 2000-2017, reflecting the trends in our country's movement towards universal health coverage (UHC) and a reduction in catastrophic medical expenses paid by patients from their own funds within the framework of the tasks for achieving the Sustainable Development Goals by 2030. It is emphasized that for our country it is of great interest to adapt the successful experience of developed and actively developing countries in using targeted integrated strategies for development of UHC programs aimed at giving priority to health in the system of public financing measures. This is confirmed by the data that for the period 2000-2017 against the background of an increase in the share of replacing the missing state funds with cash funds of citizens in the total health budget of our country from 30% to 40%, there was a parallel increase in the number of households, in the structure of the budgets of which the share of health expenditures exceeded 10% of their total financial resources. According to the analysis of monitoring data, the increase in the number of Russian families with this form of catastrophic costs of medical care reached in 2018 the number of 7,532,579 cases with a prevalence rate of 5.23%. These indicators are higher than the data levels for 1997 by more than 2.2 and 2.1 times, respectively. At the same time, the risk of financial catastrophe for families due to the need to seek surgical care in 2018 was noted in 21.3% of cases (WB, 2019). The study emphasizes the importance of scientific assessment of the consequences and prospects for the increased participation of private commercial institutions in implementation of the government program of the State guarantees of free medical assistance to citizens. The significance of such a study is due to the trends of increasing volume of the market for provision of disparate medical services and the need, therefore, to develop optimal intersectoral strategic approaches to development of both the public healthcare system and commercial medicine in the interests of ensuring health and well-being of the population.
Stereotypes of Old Age
Authors: Monteiro Machado Christiane , Pedro Sousa Jorge
Published: March 2020

Ageing, more than a demographic phenomenon (a consolidated process in Europe, still a recent one in Brazil), is a social construction influenced by the media. Advertising, which simultaneously reflects and contributes to the construction of social values, uses stereotypes as a tool for creating easily identifiable characters. This study aims at identifying aspects explored by advertising messages using stereotypes to portray older people. The sample consists of nineteen pieces selected from more than 4,500 posts on Facebook and Youtube by the ten companies with the largest advertising spending in Brazil from July 2017 to June 2018. Among the 104 pieces that feature elderly people, nineteen did use stereotypes. In twelve of them, positive stereotypes, always related to longlife accumulated experience, while seven included negative traits, such as elderly people losing touch with reality, having difficulties with technology, poor social interaction, physical impairements, or old-fashioned clothing. Negative stereotyping reflects an outdated perspective of the ageing process.
Measuring Currency Power from 2005 to 2018
Authors: Kotarski Kristijan , Tan Alexander C.
Published: March 2020

The main research goal of this paper is to empirically assess the state of US currency power relative to its main rivals in the period between 2005 and 2018. The most novel aspect of our inquiry is the design of three new composite indices called: Monetary Capability Index (MCI), Quality of Governance Index (QGI) and Currency Internationalization Index (CII). We argue that those indices are indispensable in an attempt to empirically measure the concept of currency power, both its underlying material and non-material resources, as well as the degree of their effective exploatation. Based on the conducted analysis it is visible that material resources are a necessary but not sufficient condition to wield and exert currency power which we proxy by currency internationalization. In that regard quality of governance remains indispensable to this effort. Our measurement shows that US currency power remains unshattered by the global financial crisis (GFC) and US dollar is still placed firmly at the top of international monetary and credit hierarchy. In spite of dangers emanating from Trump’s erratic policy, US rivals either face weakening of their currency power in terms of their monetary capability or still lag far behind the US in terms of their quality of governance.
The Meta-Dynamic Nature of Consciousness
Authors: Barnden John
Published: March 2020

How, if at all, consciousness can be part of the physical universe remains a baffling problem. This article outlines a new, developing philosophical theory of how it could do so, and offers a preliminary mathematical formulation of a physical grounding for key aspects of the theory. Because the philosophical side has radical elements, so does the physical-theory side. The philosophical side is radical, first, in proposing that the productivity or dynamism in the universe that many believe to be responsible for its systematic regularities is actually itself a physical constituent of the universe, along with more familiar entities. It also proposes that instances of dynamism can themselves take part in physical interactions with other entities, this interaction then being “meta-dynamism” (a type of metacausation). Secondly, the theory is radical, and unique, in arguing that consciousness is necessarily partly constituted of meta-dynamic auto-sensitivity, in other words it must react via meta-dynamism to its own dynamism, and also in conjecturing that some specific form of this sensitivity is sufficient for and indeed constitutive of consciousness. This leads to a proposal for how physical laws could be modified to accommodate meta-dynamism, via the radical step of including elements that explicitly refer to dynamism itself.
Atmospheric Transport, a Major Pathway of Microplastics to Remote Regions
Authors: Evangeliou Nikolaos , Grythe Henrik , Klimont Zbigniew , Heyes Chris , Eckhardt Sabine , Lopez-Aparicio Susana , Stohl Andreas
Published: March 2020

In recent years, marine, freshwater and terrestrial pollution with microplastics has been discussed extensively, whereas atmospheric microplastic transport has been largely overlooked. Here, we present the first global simulation of atmospheric transport of microplastic particles produced by road traffic (TWPs – tire wear particles and BWPs – brake wear particles), a major source that can be quantified relatively well. We find a high transport efficiency of these particles to remote regions, such as the Arctic Ocean (14%). About 34% of the emitted coarse TWPs and 30% of the emitted coarse BWPs (100 kt yr-1 and 40 kt yr-1 respectively) were deposited in the World Ocean. These amounts are of similar magnitude as the total estimated terrestrial and riverine transport of TWPs and fibres to the ocean (64 kt yr-1). Atmospheric transport of microplastics is thus an underestimated threat to global terrestrial and marine ecosystems and affects air quality on a global scale, especially considering that other large but highly uncertain emissions of microplastics to the atmosphere exist. High latitudes and the Arctic are highlighted as an important receptor of mid-latitude emissions of road microplastics, which may imply a future climatic risk, considering their affinity to absorb solar radiation and accelerate melting.
Twin Mammals and COVID-19: Life and Science of the Suspects
Authors: Anjum Naser A.
Published: March 2020

The world is puzzling over the origin of the current outbreak of the coronavirus disease (COVID-19) that is caused by a novel coronavirus-2019 (2019-nCoV). As of 25th March 2020, the World Health Organization has reported 4,14,179 confirmed cases and 18,440 confirmed deaths in total due to COVID-19. To this end, two unique mammals namely bats and pangolins are being investigated for their potential link to COVID-19. However, the evidence so far gathered in this context is far from clear. This paper aimed to: (i) enlighten the major aspects of life of bats and pangolins; (ii) briefly discusses their potential link to COVID-19; and also (iii) to highlight the way forward. The outcomes may contribute to future research on the subject.
Ontological and Bioinformatic Analysis of Anti-Coronavirus Drugs and Their Implication for Drug Repurposing against COVID-19
Authors: Liu Yingtong , Chan Wallace , Wang Zhigang , Hur Junguk , Xie Jiangan , Yu Hong , He Yongqun
Published: March 2020

Coronavirus-infected diseases have posed great threats to human health. In past years, highly infectious coronavirus-induced diseases, including COVID-19, SARS, and MERS, have resulted in world-wide severe infections. Our literature annotations identified 72 chemical drugs and 27 antibodies effective against at least one human coronavirus infection in vitro or in vivo. Many of these drugs inhibit viral entry to cells and viral replication inside cells or modulate host immune responses. Many antimicrobial drugs, including antimalarial (e.g., chloroquine and mefloquine) and antifungal (e.g., terconazole and rapamycin) drugs as well as antibiotics (e.g., teicoplanin and azithromycin) were associated with anti-coronavirus activity. A few drugs, including remdesivir, chloroquine phosphate, favipiravir, and tocilizumab, have already been reported to be effective in treating COVID-19. After mapping our identified drugs to three ontologies ChEBI, NDF-RT, and DrON, many features such as roles and mechanisms of action (MoAs) of these drugs were identified and categorized. For example, out of 35 drugs with MoA annotations in NDF-RT, 34 have MoAs of different types of inhibitors and antagonists. Two clustering analyses, one based on ChEBI-based semantic similarity, the other based on drug chemical similarity, were performed to cluster over 60 drugs to new categories. Moreover, PCA analysis of anti-coronavirus drugs found differences in physicochemical properties between those inhibiting viral entry and viral replication. A total of 137 host genes were identified as the targets of 47 anti-coronavirus drugs, resulting in a network of 370 interactions among these drugs and targets. Chlorpromazine, dasatinib, and anisomycin are the hubs of the drug-target network with the highest number of connected target proteins. Many enriched pathways such as calcium signaling and neuroactive ligand-receptor interaction pathways were identified. These findings may be used to facilitate drug repurposing against COVID-19.
Menstruation Distress Is Strongly Associated with Hormone-Immune-Metabolic Biomarkers
Authors: Roomruangwong Chutima , Sirivichayakul Sunee , Matsumoto Andressa Keiko , Michelin Ana Paula , Semeao Laura de Oliveira , Pedrao João Victor de Lima , Barbosa Decio S. , Moreira Estefania G. , Maes Michael
Published: March 2020

Objective: To examine the associations between menstruation features and symptoms and hormone-immune-metabolic biomarkers. Methods: Forty-one women completed questionnaires assessing characteristic menstruation symptoms, duration of menstrual cycle and number of pads used/day and completed the Daily Record of Severity of Problems (DRSP) during the consecutive days of their menstrual cycle. Menses-related symptoms (MsRS) were computed from the sum of 10 pre- and post-menses symptoms and the menstruation blood and duration index (MBDI) was computed based on the daily number of pads and duration of menses. We assayed serum levels of various biomarkers at days 7, 14, 21, and 28 of the subjects’ menstrual cycle. Results: MBDI was significantly associated with a) MsRS including low abdominal cramps, and gastro-intestinal (GI) and pain symptoms (positively); b) plasma levels of haptoglobin (Hp), CCL5, insulin growth factor (IGF)-1, and plasminogen activator inhibitor (PAI)1 (all positively); and c) estradiol and paraoxonase (PON)1 arylesterase activity (both inversely). MsRS were significantly predicted by CCL5 and IGF-1 (both positively) and progesterone (inversely). Low-abdominal cramps, and gastro-intestinal and pain symptoms were associated with lower progesterone levels. The MBDI+MsRS score was significantly predicted by the cumulative effects of (in descending order of importance): Hp, IGF-1, PON1 arylesterase, estradiol and PAI. Conclusion: Menstruation-related features including estimated blood loss, duration of menses, cramps, pain and GI symptoms are associated with hormone-immune-metabolic biomarkers, which mechanistically may explain those features. Women with an increased MBDI+MsRS index ≥ 0.666 percentile may be considered to have menstruation-related distress, including dysmenorrhea symptoms.
SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2
Authors: Tetz George , Tetz Victor
Published: March 2020

Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prion-like domains are critical for virulence and the development of therapeutic targets; however, the prion-like domains in the SARS-CoV-2 proteome have not been analyzed. In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein, since SARS-CoV-2 was the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein. The presence and unique distribution of prion-like domains in the SARS-CoV-2 receptor-binding domains of the spike protein is particularly interesting, since although the SARS-CoV-2 and SARS-CoV S proteins share the same host cell receptor, angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 demonstrates a 10- to 20-fold higher affinity for ACE2. Finally, we identified prion-like domains in the α1 helix of the ACE2 receptor that interact with the viral receptor-binding domain of SARS-CoV-2. Taken together, the present findings indicate that the identified PrDs in the SARS-CoV-2 receptor-binding domain (RBD) and ACE2 region that interact with RBD have important functional roles in viral adhesion and entry.
Role of GUCA1C in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in Zebrafish
Authors: Morales-Cámara Samuel , Alexandre-Moreno Susana , Bonet-Fernández Juan-Manuel , Atienzar-Aroca Raquel , Aroca-Aguilar José-Daniel , Ferre-Fernández Jesús-José , Méndez Carmen-Dora , Morales Laura , Fernández-Sánchez Laura , Cuenca Nicolás , Coca-Prados Miguel , Martínez-de-la-Casa José-María , Garcia-Feijoo Julián , Escribano Julio
Published: March 2020

Primary congenital glaucoma (PCG) is a heterogeneous, inherited, and severe optical neuropathy caused by apoptotic degeneration of the retinal ganglion cell layer. Whole-exome sequencing analysis of one PCG family identified two affected siblings who carried a low-frequency homozygous nonsense GUCA1C variant (c.52G>T/p.Glu18Ter/rs143174402). This gene encodes GCAP3, a member of the guanylate cyclase activating protein family, involved in phototransduction and with a potential role in intraocular pressure regulation. Segregation analysis supported the notion that the variant was coinherited with the disease in an autosomal recessive fashion. GCAP3 was detected immunohistochemically in the adult human ocular ciliary epithelium and retina. To evaluate the ocular effect of GUCA1C loss-of-function, a guca1c knockout zebrafish line was generated by CRISPR/Cas9 genome editing. Immunohistochemistry demonstrated the presence of GCAP3 in the non-pigmented ciliary epithelium and retina of adult wild-type fishes. Knockout animals presented up-regulation of the glial fibrillary acidic protein in Müller cells and evidence of retinal ganglion cell apoptosis, indicating the existence of gliosis and glaucoma-like retinal damage. In summary, our data provide evidence for the role of GUCA1C as a candidate gene in PCG and offer new insights into the function of this gene in the ocular anterior segment and the retina.
Safety Recommendations for Evaluation and Surgery of the Head and Neck during the COVID-19 Pandemic
Authors: Givi Babak , Schiff Bradley A. , Chinn Steven B. , Clayburgh Daniel , Iyer N. Gopalkrishna , Jalisi Scharukh , Moore Michael G. , Nathan Cherie-Ann , Orloff Lisa A. , O'Neill James P. , Parker Noah , Zender Chad , Morris Luc G.T. , Davies Louise
Published: March 2020

Importance: The rapidly expanding 2019 novel coronavirus pandemic (COVID-19, caused by the SARS-CoV-2 virus) has challenged the medical community to an unprecedented degree. Physicians and healthcare workers are at added risk of exposure and infection during the course of the patient care. Due to the rapid spread of this disease through respiratory droplets, healthcare providers such as otolaryngologists-head & neck surgeons who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures are particularly at risk. Here we present a set of safety recommendations based on our review of literature and communications with physicians with first-hand knowledge of safety procedures during the 2019 COVID-19 pandemic.Observations: A high number of healthcare providers were infected during the first phase of the pandemic in Wuhan province. Subsequently, by adopting strict safety precautions, other regions were able to achieve high levels of safety for healthcare providers without jeopardizing the care of patients. We reviewed the most common procedures related to the examination and treatment of upper aerodigestive tract diseases. Each category was reviewed based on the potential risk imposed to healthcare workers. Specific recommendations were made, based on the literature, when available, or consensus best practices. Specific safety recommendations were made for performing tracheostomy in COVID-19 patients. Conclusions and Relevance: Preserving highly skilled healthcare work force is a top priority for any community and healthcare system. Based on the experience of healthcare systems in Asia and Europe, by following strict safety guidelines, the risk of exposure and infection of healthcare providers could be significantly reduced, while providing high levels of care. The provided recommendations could be used as broad guidance for all healthcare workers who are involved with the care of COVID-19 patients.
Morphological Changes in H1299 Human Lung Cancer Cells Following Millimeter-Wave Irradiation
Authors: Komoshvili Konstantin , Beker Tzippi , Levitan Jacob , Yahalom Asher , Barbora Ayan , Liberman- Aronov Stella
Published: March 2020

Efficiently targeted cancer therapy without causing detrimental side effects is necessary for alleviating patient care and improving survival rates. This paper presents observations of morphological changes in H1299 human lung cancer cells following MMW irradiation (75 – 105 GHz) at a non-thermal power density of 0.2 mW/cm2, investigated over 14 days of subsequent physiological incubation following exposure. Microscopic analyses of physical parameters measured indicate MMW irradiation induces significant morphological changes characteristic of apoptosis and senescence. The Immediate short-term stress responses translate into long-term effects, retained over the duration of the experiment(s); reminiscent of the phenomenon of Accelerated Cellular Senescence (ACS) achieving terminal tumorigenic cell growth. Further, results were observed to be treatment-specific in energy (dose) dependent manner and were achieved without the use of chemotherapeutic agents, ionizing radiation or thermal ablation employed in conventional methods; thereby overcome associated side effects. Adaptation of the experimental parameters of this study in clinical oncology concomitant with current developmental trends of non-invasive medical endoscopy alleviates MMW therapy as an effective treatment procedure for human non-small cell lung cancer (NSLC)