bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical financial and accounting issues of early-stage innovative enterprises
Authors: Bethlendi András , Urbanics Roxána
Published: November 2018

While the most important financial and accounting issues of early-stage enterprises with fast growth potential (startups) are widely covered in practice-oriented literature, academic studies do not deal with this subject. In the author’s opinion, this subject should receive more attention in academic writing, as inappropriate financial management can make it more difficult for startups to raise capital at a later stage of operation and, thus, to grow further. This paper is based on a sample of financial and tax due diligences of Hungarian startups. The authors intended to present some of the issues identified and relevant also to startups operating outside Hungary. The sample shows that due to a loss making operation in the early years, this type of companies can quickly use up their equity and, therefore, they need continuous ownership (equity) financing. The sample demonstrates that debt financing is not a viable option for this group of companies, the only option for them is venture capital financing. The authors confirmed the positive relation between startups and R&D&I. In their opinion, compliance with the rules and the optimization permitted by the rules themselves is highly significant for startups to manage their high upfront losses and to attain their general aim to raise investment capital. The financial and tax due diligences at startups allowed to identify several inappropriate practices due to complicated accounting and tax laws.
Utilizing a professional role model for development of a learner-centered learning program for managers
Authors: Maltsev Eduard
Published: November 2018

The article is devoted to learner-centered learning program development for adult learners, which are experienced professionals – chief executives. The high speed of learning and precise learning outcomes are seen as the main need of an executive in a learner role. A learner-centered learning program satisfies the need.The article suggests the use of a professional role model of a learner – after learning program completion – as a main tool for the development of an appropriate learner-centered learning program. The details of the professional role model, as well as an algorithm of learner-centered learning program development, are discussed.One of the key problems in learning program development is that the skills, competencies and capabilities developed during learning programs often can’t be applied outside the learning program – in “real life” contexts. To enable a learner to be successful in real contexts, it is suggested to use a role concept in different contexts. The learning program in this case should develop not only the ability to play a role, but also play it in different contexts; not just to acquire new roles, but to be able to reduce roles for simpler ones, as well as to compose new roles.
Analogies in behavioral and emotional disorders between dogs and humans
Authors: GOLEMAN MAŁGORZATA , OBŁODECKA ANNA , KRUPA WANDA , ROZEMPOLSKA-RUCIŃSKA IWONA
Published: November 2018

Human-dog interactions not only shape interspecies relationships in the social context, but also affect the emotional and psychological state of both man and animal. One consequence of living in a developed and urbanized environment is an increase in the occurrence of civilization diseases, which include psychological and emotional disorders occurring not only in humans, but also in animals. The aim of the study was to analyze selected behavioral problems of dogs in the context of their equivalents among human mental illnesses. Such similarities have been demonstrated in early-development disorders, affective disorders, personality disorders and obsessive-compulsive disorders. The development of knowledge about emotional disorders manifested by dogs may have significant importance in the prevention and treatment of human mental illnesses by providing information about their genesis, neurophysiological basis and heritability.
Diseases of shrimps and natural methods to protect their health
Authors: KAZUŃ BARBARA , KAZUŃ KRZYSZTOF , SIWICKI ANDRZEJ KRZYSZTOF
Published: November 2018

Shrimp farming is an economically important part of aquaculture. Shrimps constitute the largest portion of shellfish intended for human consumption. According to the World Organization for Animal Health (OIE), viral diseases pose the most serious threat to shrimp farming. There are currently six viral and two bacterial diseases on the OIE list. The most serious viral diseases are white spot disease (WSD), Taura syndrome (TS), infection with yellow head virus genotype 1 (YHV), infectious hypodermal and haematopoietic necrosis (IHHN), infectious myonecrosis (IMN) and white tail disease (WTD), whereas the most dangerous bacterial diseases are acute hepatopancreatic necrosis disease (AHPND) and necrotizing hepatopancreatitis (NHP). All these diseases result in high mortality, thus limiting shrimp production and causing large economic losses. Therefore, effective preparations are constantly sought to control infectious diseases in shrimps. Probiotics and immunostimulants, thanks to their demonstrated antibacterial and antiviral effects, as well their positive impact on the immune system, may play a crucial role in protecting the health of shrimps.
Rectal palpation for pregnancy checks in cows – the past or an alternative to modern diagnostic methods
Authors: JAŚKOWSKI JĘDRZEJ M. , KACZMAROWSKI MICHAŁ , KULUS JAKUB , JAŚKOWSKI BARTŁOMIEJ M. , HERUDZIŃSKA MAGDALENA , GEHRKE MAREK
Published: November 2018

Early diagnosis of pregnancy in cattle is an important factor determining the profitability of breeding. It allows to shorten the intercalving period, by accelerating the next insemination procedure or diagnosing the cause of infertility. Palpation of the reproductive system by rectal examination isthe method used for more than 100 years it involves palpation of the uterine horns to detect the fetal vesicle, fetus water and the embryo itself. The earliest period when a fetal bladder can be detected is the 28th day after insemination in heifers and 32-35 in multiparous. The method is fast, cheap, does not require additional equipment, and the result is immediate. The ability to carry out the proper and effective recognition with this method is not easy and requires theoretical and practical preparation. The method also involves the risk of causing fetal damage and, as a result, loss of pregnancy and deterioration of the cow’s well-being. The modernization of the method is the introduction of an ultrasound for rectal examination, which allows to increase the efficiency of diagnosis and shorten the time from insemination to the examination. Diagnosis of early pregnancy through rectal examination, although it has been used for a long time, has not lost its importance or popularity. Although new methods of diagnosing pregnancy still appear in today’s practice, they do not affect its importance.
Quality problems in mechanically separated meat
Authors: ŁASZKIEWICZ BEATA , SZYMAŃSKI PIOTR , KOŁOŻYN-KRAJEWSKA DANUTA
Published: November 2018

Mechanically separated meat (MSM) is obtained from bones or fragments with naturally adherent soft tissue by mechanical separation of soft tissue residues from bones remaining after cutting and punching poultry, pork and beef carcasses. Mechanically separated meat is a raw material commonly used in processing in Poland and other countries. The dominant species in the production of mechanically separated meat in Europe is poultry, mainly because of the increase in the consumption of boneless meat and its products. Mechanically separated meat is characterized by poorer technological and physicochemical properties and lower durability compared to poultry meat cut by hand. The high microbiological contamination of raw material limits its further use. The microbiological quality of mechanically separated meat has a significant impact on the microbiological stability and health safety of products manufactured from it. In industrial practice, mechanically separated meat is preserved by freezing or curing. In view of problems with the microbiological quality of mechanically separated meat, it seems advisable to search for new methods of preserving MSM and to improve the existing ones
Phylogenetic analysis of spring viremia of carp virus (SVCV) identified in Poland
Authors: MAJ-PALUCH JOANNA , BORZYM EWA , MATRAS MAREK , STACHNIK MAGDALENA , REICHERT MICHAŁ
Published: November 2018

Spring viremia of carp (SVC) is a disease caused by a virus belonging to the genus Vesiculovirus, family Rhabdoviridae. The SVC virus is divided into four genogroups, Ia, Ib, Ic, and Id, due to its geographical distribution. This study aimed to identify the genotype of the SVC virus circulating in Poland. Polish SVC virus isolates were propagated on EPC and FHM cell lines, and genetic material (RNA) was isolated. The virus was detected in test samples by reverse transcription, sequenced and analyzed using MEGA 6.06 software. The phylogenetic tree was constructed by the Neighbor-Joining method. The results of phylogenetic analysis revealed the presence of two genogroups of the SVC virus in Poland. Most of Polish isolates belonged to the genogroup Id, as do isolates AY196200 from the Czech Republic, Z37505 from Belgium and EF593149 from the United States. Only two Polish isolates from Silesian Voivodeship were more closely related to Chinese and US isolates belonging to the genogroup Ia. There were no isolates belonging to the genogroups Ib and Ic. Nucleotide sequence analysis revealed certain point mutations between particular isolates. Knowledge on the genetic variants of the SVC virus circulating in Poland will be useful in epizootic investigations and preventive measures to protect Polish aquaculture from new variants from the neighboring countries
Effects of ectoine on animals and humans
Authors: SZABELAK ALEKSANDRA , SCHULZ MICHAŁ , BOWNIK ADAM
Published: November 2018

Some species of soil bacteria and most organisms living in extreme environments such as salt lakes or coal or salt mines have effective protective mechanisms that enable them to function under adverse conditions. A common way to protect against harmful environmental factors is the production and accumulation of substances with an osmoprotective effect. One of such substances is ectoine, or 1,4,5,6-tetrahydro-2-methyl-4- -pyrimidine-carboxylic acid of an amphoteric nature. The effect of ectoin, mainly based on the binding of water molecules, has found wide application in the protection of macromolecules and cells. This work is a review of the use of this amino acid in human and veterinary medicine.
Animals in publications of Polish Catholic thinkers of the first half of the twentieth century
Authors: SMYKOWSKI KRZYSZTOF
Published: November 2018

The aim of the article is to analyze the discussion of man’s relation to animals in the publications of Polish Catholic thinkers of the first half of the twentieth century. At that time, a significant change took place in the relationship of man to other living beings, which had its sources in contemporary cultural and philosophical trends. An important goal of those publications was to counter the increasingly popular view that Christianity and the teaching of the Church were the cause of ill-treatment of animals. Catholic thinkers focused their analysis on several issues. They pointed to saints who had been sensitive to the well-being of animals, stigmatized cruelty and showed the Church’s commitment to improving animal welfare.
DOS DIREITOS HUMANOS NO TRANSUMANISMO: ALGUMAS REFLEXÕES
Authors: Estêvão Carlos Alberto Vilar
Published: November 2018

O autor começa por caracterizar sumariamente os direitos humanos na atualidade, realçando as controvérsias que têm surgido em torno da sua racionalidade e utilidade, num contexto complexo que aponta para outros valores e para uma nova conceção de humanismo. Na segunda parte, o artigo explana algumas reflexões sobre o lugar dos direitos humanos no transumanismo, entendido este como um novo estádio da humanidade, com pessoas altamente identificadas com as tecnologias, estilos de vida e visões do mundo, que colocam o transumano como horizonte biotecnológico. O autor dá uma particular ênfase às contradições a que os direitos são sujeitos, comprimidos entre as ambições progressistas dos defensores do transumanismo e as críticas conservadoras dos seus opositores, sem deixar de realçar as potencialidades teóricas de renovação dos direitos neste novo contexto.
BRASIL: A DIFÍCIL CAMINHADA DA DEMOCRATIZAÇÃO DO DIREITO CIVIL
Authors: Abreu Barroso Lucas , Malheiros da Cunha Frota Pablo , Roldi Passamani Brígida , Moreira Andrade Lúcio
Published: November 2018

A Constituição Federal de 1988 reinaugurou o Estado Democrático de Direito no Brasil. Com alicerce nos direitos fundamentais, a “Constituição Cidadã” formatou um modelo de Estado Social cujos objetivos consistem na construção de uma sociedade livre, justa e solidária, na erradicação da pobreza e da marginalização e na promoção do bem de todos, sem preconceitos de origem, raça, sexo, cor, idade e quaisquer outras formas de discriminação. Deste contexto emerge o ideário constitucional de democracia familiar, especificamente no presente artigo, voltado ao reconhecimento da união civil entre pessoas do mesmo sexo como família. A democratização do direito civil em matéria de direito de família, para além da interpretação das normas legais vigentes conforme a Constituição está a exigir a compreensão daquilo que constitui cada indivíduo (ou grupo) destinatário dos princípios da afetividade e da solidariedade. Em histórico julgamento de 2011, o Supremo Tribunal Federal, embora tenha equiparado em direitos e deveres a união civil homoafetiva e a união civil heteroafetiva, não logrou avançar no impreterível debate sobre as questões de gênero.
DIREITOS HUMANOS, NOVAS TECNOLOGIAS E RESILIÊNCIA DO DIREITO
Authors: Flores Luis Gustavo Gomes
Published: November 2018

O presente artigo tem como tema de estudo, a importância da ideia de Resiliência nas reflexões jurídicas para pensar os Direitos Humanos em face dos desafios trazidos pelas Novas Tecnologias Digitais em uma Sociedade Complexa. Para tanto, se buscou responder o problema de pesquisa que indaga: qual a contribuição que a ideia de resiliência pode dar para pensar os Direitos Humanos em face de uma sociedade complexa, fortemente marcada pelos desafios trazidos pelas Novas Tecnologias Digitais? Trata-se de um trabalho crítico reflexivo que tem como objetivo geral, demonstrar a necessidade que se tem no Direito de pensar novas possibilidades de observação que leve em consideração a importância da inovação no Direito para enfrentar a complexidade social, fortemente marcada pelo avanço das Novas Tecnologias Digitais. Para tanto, se utilizou a método sistêmico construtivista, através de pesquisa bibliográfica. Tem-se como resultado a possibilidade de observação de novas perspectivas a serem consideradas, a partir de um potencial ainda não explorado suficientemente, mas considerando as contribuições da Resiliência do Direito abre-se novas possibilidades para tanto.

Palavras-chave: Direitos Humanos, Novas Tecnologias, Resiliência do Direito.
A INFLUÊNCIA DAS REGRAS ELEITORAIS NA SELEÇÃO DOS CANDIDATOS À DISPUTA ELEITORAL: UMA ANÁLISE COMPARADA ENTRE OS CASOS DO BRASIL E ARGENTINA
Authors: Rodrigues Marcus , Müller Gustavo André Aveline
Published: November 2018

O principal objetivo deste artigo é analisar, de forma comparada, a influência das regras eleitorais sobre os partidos políticos em geral, e, em particular, na seleção dos candidatos à disputa eleitoral na Argentina e no Brasil. Para tanto, recorreu-se à abordagem da política comparada juntamente com o aporte do neo-institucionalismo da escolha racional. Inicialmente, realizou-se uma sucinta revisão acerca dos modelos de democracia, para então entrar no debate sobre os efeitos das regras eleitorais. Depois, foram apresentados os sistemas eleitorais de ambos os países e, logo na sequência de cada caso, analisada a influência das listas eleitorais na seleção dos candidatos à disputa eleitoral. A conclusão do artigo mostra que, embora as listas eleitorais tenham um efeito prescritivo sobre a seleção dos candidatos, sua influência deve ser relativizada uma vez que outras variáveis devem ser dimensionadas para a escolha dos candidatos aos pleitos.
CAPITÃES DA AREIA: O JUIZ E SEUS ARGUMENTOS
Authors: Velten Paulo , Castillholi Carolina Assis , Silva Renan Sena
Published: November 2018

A partir do livro Capitães de Areia, de Jorge Amado, no qual um personagem, o juiz, escreve uma carta para o Jornal da Tarde manifestando sua opinião sobre cerca de cem meninos que aterrorizam a cidade de Salvador, em 1935, iniciou-se uma pesquisa que traça um paralelo entre a carta e as sentenças produzidas nos Juízos de Infância e Juventude atuais no Espírito Santo, buscando identificar os argumentos que justificam a ação de “enviar para o reformatório” os tais “Capitães de Areia”.
A CIDADE CONTEMPORÂNEA E O ESPAÇO DA CRIANÇA: INTERAÇÕES SOBRE A CIDADE, A INFÂNCIA E A APROPRIAÇÃO DO ESPAÇO PÚBLICO
Authors: Schonardie Elenise Felzke , Tondo Ana Lara
Published: November 2018

O artigo apresenta para análise a cidade como espaço, também, da criança, tendo por base a ideia de espaços lúdicos de acesso público, em especial para esse sujeito em formação, contribuindo para a estruturação e (re)significação da cidadania a partir das experiências vivenciadas nesses ambientes. Com base no questionamento “onde estão as crianças na cidade?”, o texto aborda inicialmente a dinâmica da cidade contemporânea com ênfase no papel dos citadinos na cidade e os espaços destinados à infância na estrutura urbana. Na sequência, analisa a produção do território infantil.  A pesquisa teórica utilizou-se do método de abordagem hipotético-dedutivo, por meio do procedimento bibliográfico e interpretação sociológica. E, conclui pela importância e adequação da apropriação do espaço público urbano pelas crianças, contribuindo, assim para a criação de uma cidade, não como apenas como ambiente de lutas sociais, históricas e de segregação, mas sim, como um espaço comum, compartilhado  e igualitário, no qual o ideal igualitário possa ser desenvolvido continuamente.Palavras-Chave: Cidade. Cidadania. Espaços lúdicos urbanos. Infância.
OS EFEITOS ADVINDOS DA CONDENAÇÃO DO BRASIL NO CASO DAMIÃO XIMENES LOPES NA CORTE INTERAMERICANA DE DIREITOS HUMANOS POR VIOLAÇÃO AOS DIREITOS PREVISTOS NO PACTO DE SAN JOSÉ DA COSTA RICA
Authors: Francischetto Gilsilene Passon , Aquino Bruna Pereira
Published: November 2018

O presente artigo analisa quais as consequências advindas da sentença condenatória internacional proferida em desfavor do Brasil pela Corte Interamericana de Direitos Humanos no caso Damião Ximenes Lopes tais como, condenação pecuniária, elaboração de estrutura de apoio para pessoas com adoecimento mental e capacitação dos profissionais da área da saúde mental. O primeiro capítulo traz uma análise dos Direitos Humanos no pós II Guerra Mundial e trata do sistema interamericano de Direitos Humanos, dando ênfase ao Pacto de San José da Costa Rica (1969). O segundo capítulo versa sobre a posição adotada pelo Brasil enquanto signatário da Corte Interamericana de Direitos Humanos. O terceiro capítulo trata das particularidades do caso Damião Ximenes Lopes versus Brasil na Corte Interamericana de Direitos Humanos. Finalmente, o último capítulo discorre sobre as consequências advindas da condenação do Estado brasileiro no caso Damião Ximenes Lopes. Assim, o presente artigo objetiva descrever o papel da Corte Interamericana de Direitos Humanos na proteção dos Direitos Humanos, bem como apontar seu funcionamento, especificar as características do caso Damião Ximenes Lopes, descrevendo e analisando quais as consequências advindas da condenação do Brasil, nesse caso, no que diz respeito ao enfrentamento das questões relativas aos doentes mentais. Assim, por meio do método dialético e de revisão bibliográfica, o artigo busca responder ao seguinte questionamento: Quais os efeitos advindos da condenação do Brasil na Corte Interamericana de Direitos Humanos por violação a vários direitos do Pacto de San José da Costa Rica no caso Damião Ximenes Lopes?
The Hydrosilylation and Cyanosilylation of Ketones Catalyzed using Metal Borohydrides
Authors: Liu Yu , Zhang Duodong , Ma Yangyang , Li Jiayun , Bai Ying , Peng Jiajian
Published: November 2018

Aim and Objective:

The hydrosilylation reaction of carbonyl compounds has emerged as a powerful
method in organic synthesis. The catalytic hydrosilylation of ketones is a valuable transformation because it
generates protected cyanosilylation reaction of carbonyl compounds is an efficient procedure for the synthesis
of silylated cyanohydrins, which are readily converted into useful functionalized compounds, such as cyanohydrins,
α-hydroxy acids, β-amino alcohols and other biologically active compounds.

Materials and Methods:

A facile, economic and efficient method has been developed for the hydrosilylation
and cyanosilylation of ketones using metal borohydrides. A series of silylated ethers and silylated cyanohydrins
can be isolated via direct distillation.

Results:

The catalytic properties of a range of metal borohydrides in the hydrosilylation reaction of acetophenone
with diphenylsilane were investigated. The relative catalytic activity of the borohydride catalyst studied
was as follows: (CH3)4NBH4> (PhCH2)(CH3)3NBH4> (CH2CH3)4NBH4> (CH3CH2CH2CH3)4NBH4> NaBH4>
KBH4> LiBH4. The cyanosilylation of acetophenone using trimethylsilyl cyanide (TMSCN) in the presence of
NaBH4 occurred under similar reaction conditions. An excellent reaction rate and high conversion were obtained.

Conclusion:

The metal borohydride-catalyzed hydrosilylation alcohols in one step. The and cyanosilylation of
ketones could be carried out smoothly under mild reaction conditions. Among the metal borohydrides studied,
an excellent reaction rate and high conversion were obtained using NaBH4, NaBH (CH2CH3)3 or (alkyl)4 NBH4
as the reaction catalyst.
Synthesis and Analgesic Activity of Monoterpenoid Aldehyde-derived Hydro-2H-chromeneols
Authors: Il'ina Irina , Morozova Ekaterina , Korсhagina Dina , Volсho Konstantin , Tolstikova Tat'yana , Salakhutdinov Nariman
Published: November 2018

Background:

Despite a variety of drugs used to stop acute pain, problems related to their
insufficient efficacy and undesirable side effects have remained unresolved. Therefore, the search for
analgesics of new structural types, which combine high activity with low toxicity, is a topical issue.
It is known that a number of compounds with a hydrogenated 2H-chromene skeleton exhibit
significant analgesic activity in in vivo tests.

Methods:

New hydro-2H-chromenols containing monoterpenoid moieties were obtained via one-pot
synthesis by the interaction between para-menthane alcohols and commercially available
monoterpene aldehydes: Citral, hydroxycitronellal, myrtenal, and perillaldehyde. The analgesic
activity of these compounds wаs studied in the acetic acid-induced writhing test and hot plate test.

Results:

The target compounds were characterized using NMR and HR-MS. Most of them exhibited
pronounced analgesic activity.

Conclusion:

Due to high analgesic activity, (2S,4aR,8R,8aR)-2-((E)-2,6-dimethylhepta-1,5-dien-1-
yl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diol is considered as candidate compound
to participate in further research.
Analytical Methods for the Determination of Sartans in Pharmaceutical Formulations and Biological Fluids: A Review
Authors: Smerikarova Miglena , Bozhanov Stanislav , Maslarska Vania
Published: November 2018

Background:

Sartans are mostly used as a part of combination with additional medicines in the therapy of essencial hypertension. Preferred combinations are ARB and thiazide diuretics (Hydrochlorothiazide (HCT) and Chlorthalidone (CHL)) or ARB and calcium antagonists. The number of sartans mostly prescribed by specialists is only seven - Candesartan (CDS), Eprosartan (EPS), Irbesartan (IBS), Losartan (LOS), Olmesartan (OMS), Telmisartan (TMS) and Valsartan (VLS).

Methods:

The widespread use of sartans in the treatment of hypertension requires reliable methods of analysis. Bulk drugs and pharmaceutical preparations should be analyzed to ensure the quality of the medicinal products reaching patients. On the other hand, the analysis of drugs in biological fluids aims to trace and improve patient care by adjusting the therapeutic doses of drugs. According to our knowledge, a review devoted to the analysis of sartans was published in 2014.

Results:

Spectral methods are widely used in the analysis of bulk drugs and pharmaceutical dosage forms due to their relatively simple procedures, low reagent and sample consumption, speed, precision and accuracy combined with accessibility and comparatively low cost of common apparatus. Many papers for determination of sartans in bulk drugs and pharmaceutical preparations based on liquid chromatographic techniques were published in the available literature. Among these methods, HPLC takes the leading place but UPLC and HPTLC are also present.

Conclusion:

The widespread use of sartans in the treatment of hypertension requires reliable methods of analysis. Bulk drugs and pharmaceutical preparations should be analyzed to ensure the quality of the medicinal products reaching patients. On the other hand, the analysis of drugs in biological fluids aims to trace and improve patient care by adjusting the therapeutic doses of drugs. Since 2014, many articles have been published on the sartans analysis and this provoked our interest to summarize the latest applications in the analysis of sartans in pharmaceutical formulations and biological media. Articles published from 2014 to 2018 are covered.
New Drug Discovery from Medicinal Plants and Phytoconstituents for Depressive Disorders
Authors: Dereli Fatma Tuğçe Gürağaç , Ilhan Mert , Akkol Esra Küpeli
Published: November 2018

Background & Objective: Depression, a risk factor for several serious diseases, is a highly prevalent and life-threatening psychiatric disorder. It can affect the individual’s position in life and reduce the living standards. The research on the use of medicinal plants in treating this disease has increased enormously because of the possible low rehabilitation rate and side effects of available synthetic drugs, such as sexual dysfunction, nausea, fatigue, insomnia, hypersomnia, and weight gain.

Conclusion:

Therefore, this review aimed to draw attention to the antidepressant effects of culinary herbs and traditional medicinal plants and their active components, thereby promoting their use in the development of more potent antidepressants with improved side effect profile.
Protein Network Analysis to Prioritize Key Genes and Pathway for Stress-Mediated Neurodegeneration
Authors: Srivastava Neha , Mishra Bhartendu Nath , Srivastava Prachi
Published: November 2018

Background:

Oxidative Stress (OS) has been implicated in the pathophysiology of many neurodegenerative diseases. OS can cause cellular damage that results in cell death due to overproduction of reactive oxygen species (ROS) that may play the crucial role in the disease progression. An impaired mechanism in correlation with reduced expression of antioxidant proteins is the very common feature among most of the age-related disorders. Variousin-vitroandin-vivostudies suggest the major contribution of oxidative stress in neurodegeneration. Role of Nrf2 gene is well established as a neuroprotective gene especially in concern with stress-mediated neurodegeneration. Nrf2 is a bZIP transcription factor that forms the heterodimer with small Maf protein and transcription factor AP1 that regulates transcription by binding to ARE which coordinates the transcription of genes involved in phase II detoxification and an antioxidant defense that is used to protect the cell from oxidative stress.

Aim:

The currentinsilicostudy was attempted to prioritize key genes and pathway in stress-mediated neurodegeneration through network-based analysis.

Methods:

Protein-protein interaction network was constructed and analyzed using 63 Nrf2 regulating candidate genes obtained from NCBI database based on literature studies usingSTRING 10.0database andCytoscape v 3.6.0software plug-inNetwork Analyzer.Further, the functional enrichment analysis of identified gene was done usingPANTHER GENE ONTOLOGYsoftware and DAVID tool.

Results:

Based on network topological parameter, TP53, JUN, MYC, NFE2L2, AKT1, PIK3CA & UBC were identified as the key gene in the network. Among them, TP53 gene was obtained as a super hub gene with the highest Betweenness Centrality (BC) and node degree. The functional enrichment analysis was done usingPANTHER GENE ONTOLOGYsoftware and DAVID tool reveals their significant role in neurotrophin signaling pathway, MAPK signaling pathway, cellular response to stress & in the regulation of stress.

Conclusion:

The network analysis will help in prioritizing genes in the pathway that helps in understanding the underlying mechanism of disease. Thus, further study on these genes and their biological mechanism and pathway may, therefore, provide a potential target for the treatment of stress-mediated neurodegeneration.
On Performance of Binary Flower Pollination Algorithm for Rectangular Packing Problem
Authors: Virk Amandeep K. , Singh Kawaljeet
Published: November 2018

Background:

Metaheuristic algorithms are optimization algorithms capable of finding
near-optimal solutions for real world problems. Rectangle Packing Problem is a widely used industrial
problem in which a number of small rectangles are placed into a large rectangular sheet to maximize
the total area usage of the rectangular sheet. Metaheuristics have been widely used to solve
the Rectangle Packing Problem.

Objective:

A recent metaheuristic approach, Binary Flower Pollination Algorithm, has been used to
solve for rectangle packing optimization problem and its performance has been assessed.

Methods:

A heuristic placement strategy has been used for rectangle placement. Then, the Binary
Flower Pollination Algorithm searches the optimal placement order and optimal layout.

Results:

Benchmark datasets have been used for experimentation to test the efficacy of Binary Flower
Pollination Algorithm on the basis of utilization factor and number of bins used. The simulation
results obtained show that the Binary Flower Pollination Algorithm outperforms in comparison to
the other well-known algorithms.

Conclusion:

BFPA gave superior results and outperformed the existing state-of-the-art algorithms in
many instances. Thus, the potential of a new nature based metaheuristic technique has been discovered.
Boldo, Its Secondary Metabolites and their Derivatives
Authors: Cassels Bruce K. , Fuentes-Barros Gonzalo , Castro-Saavedra Sebastián
Published: November 2018

Boldo leaves (Boldo folium, from Peumus boldus Mol.) are very frequently used as a medicinal herb in Chile and are exported to many countries to be used in teas or as extracts included in herbal remedies, primarily as an aid to digestion and as a mild sedative. Scientific support for these uses is scanty, and boldine, an alkaloid viewed as characteristic of the tree and present in high concentration in the bark, is extracted by specialized companies and sold as the supposed main active constituent. Consequently, boldine has been the subject of a considerable number of research papers, while some of the other alkaloids present to a greater extent in the leaves have been relatively neglected except when found in large amounts in other species. These studies range from assays of antioxidant activity to anti-inflammatory, antineoplastic and other medical applications. The essential oil, usually containing a large percentage of the toxic ascaridole, was once used as a vermifuge and is now regarded with caution, but is still of interest as a possible natural insecticide, fungicide, antiparasitic and herbicide. The last decade has seen an explosive increase in papers pointing to possible uses of boldo and its constituents. This review attempts to bring these publications together in a comprehensive way with the purpose of stimulating and orienting further research into the useful properties of this Chilean endemic tree.
A framework to guide the optimal development and use of real-world evidence for drug coverage and formulary decisions
Authors: Pearson Steven D , Dreitlein William B , Towse Adrian , Hampson Grace , Henshall Chris
Published: November 2018

Aim:
To provide a framework for optimizing the development and use of real-world evidence (RWE) in drug coverage decisions.
Materials & methods:
The Institute for Clinical and Economic Review convened a Policy Summit with representatives from 23 payer and life science companies that compose the Institute for Clinical and Economic Review membership.
Results:
Summit participants helped refine a new conceptual framework that emphasizes the central role of contextual considerations and the evidentiary argument that the RWE is intended to support in designing the process for the development and interpretation of RWE.
Conclusion:
This framework may provide a structured way for pharmaceutical manufacturers and payers to develop a shared understanding of the best way to develop RWE that will ultimately be useful in informing coverage and formulary decisions.
Self-efficacy and motivation: Improving biology learning outcomes of senior high school students
Authors: Firmansyah Fahmie , Komala Ratna , Rusdi Rusdi
Published: November 2018

There are many determining factors influence student learning achievement, including self-efficacy and motivation. The aim of this study was to assess the effect of self-efficacy and motivation on biology learning outcomes. This research was conducted at SSHS 1 of Cilegon city, in which the method used was survey using a quantitative-causal approach aided with path analysis. The sample used were 144 students. The results showed that the path coefficient of self-efficacy towards motivation obtained was 0.596, while the motivation for learning outcomes was 0.600, and self-efficacy toward learning outcomes through motivation was 0.358. These mean that there was a direct effect of self-efficacy towards motivation and motivation towards Biology learning outcomes, whereas indirect effect was possessed by self-efficacy towards Biology learning outcomes through motivation. Thus, teachers should give more attention to student’s self-efficacy and motivation to inact learning goals.
Assistant Principals’ Perceptions of the Principalship
Authors: Morgan Thomas Lee
Published: November 2018

Education research has established a significant relationship between school leadership and students’ achievement. This study considered the leadership self-efficacy and practice of public school assistant principals (AP) in the domains of facilitating a supportive collaborative learning environment, instructional leadership, school improvement, management, and family and community relations, as perceived by APs' self-report. Findings of this study suggest that,Â in addition to the strengths in the domain of facilitating a collaborative learning environment and efficacy around family and community engagement, there were explicit gaps in the instructional leadership and school improvement practices of APs that need to be addressed. The study also confirmed that there continues to be a proliferation of duties and a lack of consistent set of practices.
Une vision du futur dialogue avec Joël de Rosnay sur la coévolution entre technologie et société
Authors: Casalegno Federico
Published: November 2018

Joël de Rosnay, docteur ès sciences et ancien enseignant au renommé Massachusetts Institute of Technology, est actuellement directeur de la Cité des Sciences et de l’Industrie de Paris. Auteur de plusieurs ouvrages, parmi lesquels nous pouvons citer Les origines de la vie, Le Macroscope et L’Homme Symbiotique, il porte un regard particulièrement intéressant et original sur la coévolution entre les nouvelles technologies de l’info/communication, la société et l’homme. Il a accepté de recevoir notre groupe de recherche, le Gretech, à La Cité des Sciences et de l’Industrie afin d’explorer ensemble les enjeux du développement technologique dans nos sociétés.
A Internet que nos protege
Authors: Saraiva Luana Negrelly , Cabral Adilson
Published: November 2018

A partir de uma análise das relações interpessoais nos canais de chat, pretende-se mostrar a Internet como um espaço de proteção da mesma sociedade repressora que a criou, abrindo portas para o desenvolvimento e o resgate dos valores humanos.
Emoção e subjetividade na paixão-pesquisa em comunicação
Authors: Baptista Maria Luiza Cardinale
Published: November 2018

O presente trabalho discute os aspectos emoção e subjetividade na produção da pesquisa em Comunicação, com base no referencial de Humberto Maturana, Francisco Varela e Félix Guattari, principalmente. Trata de situar a produção do conhecimento em relação ao sujeito maquínico, característico da contemporaneidade - sujeito reconhecido pela sua emoção, como implicação intensa do ser que produz. Retoma, portanto, a relação sujeito-objeto, para sinalizar a constituição de universos de intensidade na pesquisa, universos mobilizadores, apaixonantes. Por fim, propõe algumas perspectivas para a consideração desses aspectos, no plano específico da sua implicação metodológica, da abordagem dos fenômenos comunicacionais e midiáticos.
Contrario al maná, el comunicador no baja del cielo: nacimiento, construcción o reinvención del profesional en Puerto Rico
Authors: Sepúlveda Héctor
Published: November 2018

Nuestro interés primordial fue lo siguiente: ¿Nace o se hace el buen comunicador?, Qué razones pueden explicar que el comunicador profesional obvie mencionar o minusvalore la academia o la teoría en sus testimonios o confesiones sobre su formación y desempeño profesional?, ¿Cuáles son los desafíos de la empresa a la academia comunicacional y viceversa. Y por último, ¿Cuál es la utopía de los profesionales de hoy o su reinvensión ?
El poder mediático
Authors: Ramonet Ignacio
Published: November 2018

Resumo indisponível
Do mundo objetivo ao mundo-objeto: formação do imaginário estético-cultural no capitalismo
Authors: Rosas Reis Ronaldo
Published: November 2018

É no horizonte temático do debate sobre a globalização e o pós-modernismo que se insere esse esforço de examinar criticamente a trajetória da formação do imaginário estético-cultural do homem contemporâneo com o objetivo preliminar de organizar um corpus teórico para, em outra oportunidade, defender a idéia de que no pós-modernismo a escola deve assumir a educação estética como central e fundamental no processo de mediação cultural junto à criança e o jovem.
Crítica cinematográfica: considerações do novo milênio
Authors: Moura Roberto
Published: November 2018

A crítica cinematográfica no Brasil, um tema momentaneamente em baixa, uma vez que se perdeu momentaneamente a enorme popularidade que ela tinha e tiveram alguns críticos em nossos jornais em tempos não tão distantes. Distinta tanto das matérias informativas e dos anúncios publicados nos jornais como dos artigos teórico-analíticos nas revistas especializadas, a crítica é uma coisa muito específica logo localizada pelo leitor, muitas vezes destacada pela diagramação, carimbada pela assinatura do crítico.
A questão dos gêneros
Authors: Antonio Jorge Luiz
Published: November 2018

A Revista Symposium, da Universidade Católica de Pernambuco, acolheu o primeiro resultado de um debate que ocorreu no Programa de Estudos Pós-Graduados em Comunicação e Semiótica da PUC SP, a partir do seminário de pesquisa aplicada "Gêneros na comunicação impressa, audiovisual e eletrônico-digital", ministrado pela Profa. Irene de Araújo Machado.
La prensa, la empresa, el periodismo. De la práctica cotidiana a la búsqueda de la utopía
Authors: Sepúlveda Héctor
Published: November 2018

Las siguientes notas son reflexiones teórico-utópicas que he venido haciendo hace ya algún tiempo y las cuales parten de las siguientes pistas: ¿Cuál es la relación entre el periodismo y la democracia?, ¿Cuál debe ser la caracterísitica o la función principal del periodismo?, ¿En que debe basarse la ética y la objetividad periodística? ¿En qué consiste hoy la libertad de prensa y cómo se define y reinventa ante los nuevos escenarios de las tecnologías?
Hermenêutica, teorias da representação e da argumentação no campo da comunicação
Authors: Lopes Luís Carlos
Published: November 2018

Este texto pretende explorar as possibilidades de uso da hermenêutica, das  teorias da representação e da argumentação no campo da comunicação. Deseja-se verificar os problemas de uma possível superação do paradigma informacional, baseado nas teorias da propaganda e da informação (matemática e não-matemática) que tanto influenciaram a constituição do campo dos estudos comunicacionais, instituído no pós-guerra. Deseja-se discutir os aspectos universais e locais (latino-americanos) de uma possível epistemologia da comunicação considerando tanto as incursões teóricas como a realidade prática em que estamos envolvidos. Quer-se, a partir de um balanço de algumas das opções teóricas existentes, contribuir para a construção de novos paradigmas científicos. Estes estariam relacionados às mudanças contemporâneas -  em gestação -  em nossas realidades materiais e simbólicas, pautadas na centralidade social, cultural e econômica do processo comunicacional e informacional.
Internet y el Estado ampliado: La construcción del homo ciberespacial
Authors: Madrid Javier Esteinou
Published: November 2018

La emergencia de los medios de comunicación y de las nuevas tecnologías de información en las sociedades modernas no sólo representa la maduración del modelo de sociedad de la información y la radical transformación de las superestructuras culturales de las comunidades, sino que básicamente el fenómeno más relevante que produce es la expansión intensiva de la dimensión ideológica de la sociedad.
Megalópole Recife: cultura, pós-modernidade e cidadania
Authors: Melo Patricia Bandeira de
Published: November 2018

O presente artigo apresenta uma análise de conceitos sobre a cidade, desde a visão positiva dos iluministas até o pensamento pós-moderno. Tenta ainda situar o Grande Recife dentro da visões analíticas da cidade como vício, cidade como virtude e cidade acima do bem e do mal, fazendo uma retrospectiva sobre os conceitos de flâneur, pós-modernidade, cosmopolitismo, consumo, cidadania, estudos culturais e periferia, associados à realidade local da Região Metropolitana do Recife.
Cinema brasileiro e público: o que a educação tem a ver com isso?
Authors: Reis Ronaldo Rosas
Published: November 2018

O cinema brasileiro encontra-se hoje diante da situação paradoxal de ter ultrapassado um século de existência sem que tenha conquistado, efetivamente, uma dimensão pública, uma presença social institucionalizada.
O processo eduacativo na promoção de saude bucal - uma prioridade - como fazelo funcionar
Authors: Oliveira Santos Maria Eliza
Published: November 2018

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Placas Oclusais
Authors: Villela de Gouvea Monica
Published: November 2018

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O nivel de informação da população e cirurgioes dentistas sobre os efeitos do tabgismo na saude oral
Authors: Carina Santos Bastos,
Published: November 2018

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O uso de produtos de higiene oral.
Authors: Sandro Reis Amaral
Published: November 2018

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Avaliação da utilização dos meios de radioproteção em consultórios odontológicos da cidade de Niterói.
Authors: Fernanda Baptista Ribeiro
Published: November 2018

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A importância da promoção de saúde oral para os pacientes portadores de diabetes melito
Authors: Débora Santiago Martinho
Published: November 2018

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Efeitos de programas de treinmento extra-muros sobre o desempenho e atitudes de estudantes de odontologia no Brasil
Authors: Tinoco Eduardo Muniz Barreto
Published: November 2018

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Reparo das restaurações de amálgama
Authors: Fernandes Ana Claudia da Silva
Published: November 2018

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Aperfeiçoamento e viabilidade das resinas compostas em dentes posteriores
Authors: Depes de Gouvêa Cresus Vinícius
Published: November 2018

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4. Enterococcus faecalis em retratamentos endodônticos e em casos de infecção primária associados à periodontite apical assintomática.
Authors: P. de Farias Costa Maíra
Published: November 2018

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Hipersensibilidade dentinária : possíveis causas e tratamentos
Authors: Accetta Danielle Figueiredo
Published: November 2018

Palavras chave: sensibilidade dentinária, dor, etiologia, tratamento.
Editorial 35
Authors: Vinicius Depes  de Gouvêa Dr Cresus
Published: November 2018

Editorial 35
Avaliação Clínica de três anos da técnica restauradora atraumática ( ART ) na dentição decídua.
Authors: Christina Lopes Coutinho Thereza
Published: November 2018

O presente estudo avaliou clinicamente, após três anos, 45 restaurações atraumáticas realizadas em 25 crianças entre 01 e 05 anos de idade, matriculadas em uma Unidade Municipal de Ensino Infantil em Niterói – RJ, Brasil. Todos os responsáveis assinaram o Termo de Consentimento Livre e Esclarecido, de acordo com as normas do Comitê de Ética em Pesquisa. O material restaurador utilizado foi o cimento de ionômero de vidro Ketac Molar® (3M ESPE), manipulado de acordo com as recomendações do fabricante e a técnica restauradora aplicada seguiu as instruções contidas no Guia Prático para o Tratamento Restaurador Atraumático (ART), preconizado pela OMS. A avaliação clínica das restaurações foi realizada por um examinador calibrado, com auxílio de sonda exploradora e espelho bucal, seguindo critério de Phantumvanit et al (1996), composto por códigos de 0 a 9 para avaliar a qualidade da restauração. Foi observado 40% de sucesso (escores 0-2), 40% de insucesso (escores 3-4) e 20% não pôde ser avaliado (escore 6). Considerando-se cada tipo de restauração independentemente, obteve-se sucesso em 47,3% nas de Classe I, 38,8% de Classe II e 25% de Classe III. Apenas 11% das restaurações que apresentaram falhas, desenvolv-eram cárie secundária, sendo que 77% estavam localizadas no arco in-ferior. Pôde-se concluir que, a ART representa uma boa alternativa no controle da doença cárie na dentição decídua desde que esse tratamento seja parte de um programa que contemple ações de promoção de saúde bucal, buscando o efetivo controle da doença cárie.Palavras-chave: Tratamento Restaurador Atraumático – Dentição decídua  – Cimento Ionômero de Vidro
Fechamento de diastema através do uso de resinas compostas - Relato de caso
Authors: Accetta Latempa Antonio Marcelo
Published: November 2018

Uma melhor aparência estética vem sendo cada vez mais almejada pelos pacientes, estando, inclusive, relacionada à autoestima, melhores oportunidades sociais e até mesmo profissionais. O diastema entre os incisivos centrais superiores é visto pelos pacientes como uma das maloclusões mais preocupantes e desagradáveis. Este trabalho  teve por objetivo descrever a técnica do fechamento de diastemas com uso de resinas compostas fotoativadas, através do relato de um caso clínico realizado na Clínica de Especialização em Dentística Restauradora da Faculdade de Odontologia (FO) da Universidade do Estado do Rio de Janeiro - UERJ. Concluiu-se que essa técnica é uma ótima alternativa estética em muitas situações por ser conservadora, eficaz, de baixo custo e de relativa facilidade de execução.Palavras-chave: Diastema – Resina composta.
Como aumentar a aceitação de trabalhos científicos ?
Authors: Nelson Mucha José
Published: November 2018

Um dos principais problemas da não-aceitação de alguns trabalhos científicos pelas revistas, está relacionado à  não-observação de itens fundamentais para a exposição clara do assunto. O presente trabalho tem o objetivo de relacionar uma série de pontos que os revisores das principais revistas científicas normalmente seguem, como forma de análise para aceitar ou rejeitar os trabalhos.  Uma sequncia lógica de itens para a redação dos artigos e confereência desta redação do trabalho, antes de ser enviado para análise pelos corpos editoriais das revistas científicas foi estabelecida. Ao ser seguida esta sequência de argumentação lógica adotada pelos principais revisores, a quantidade de artigos aceitos aumentará substancialmente.  Palavras-chave: Metodologia – Redação – Editoração.