bluuebunny/crossref_metadata_2025 huggingface dataset:
Criação, Difusão e Aprendizados dos Sistemas Nacionais de Políticas Públicas: Os Caminhos Heterogêneos do SNRH, SUAS e SUSP
Authors: Silva André Luis Nogueira da , Segatto Catarina , Abrúcio Fernando , Machado Gabriel
Published: January 2023

Objetivo da pesquisa: Analisar o contexto em que o formato sistêmico foi adotado pelo desenho institucional da assistência social, recursos hídricos e segurança pública no Brasil, comparando-os em termos de fatores explicativos, estrutura de governança e tipos de aprendizados.
Enquadramento teórico: A pesquisa utilizada o quadro teórico-analítico do Policy learning, para o qual as mudanças em políticas públicas resultam de processos de aprendizado em seus diferentes níveis.
The Classical Continuous Optimal Control for Quaternary Nonlinear Parabolic Boundary Value Problems
Authors: Al-Hawasy Jamil A. Ali , Al-Anbaki Wissam A. Abdul-Hussien
Published: January 2023

In this paper, our purpose is to study the classical continuous optimal control (CCOC)  for quaternary nonlinear parabolic boundary value problems (QNLPBVPs). The existence and uniqueness theorem (EUTh) for the quaternary state vector solution (QSVS) of the weak form (WF) for the QNLPBVPs with a given quaternary classical continuous control vector (QCCCV) is stated and proved via the Galerkin Method (GM) and the first compactness theorem under suitable assumptions(ASSUMS). Furthermore, the continuity operator for the existence theorem of a QCCCV dominated by the QNLPBVPs is stated and proved under suitable conditions.
Digital Data Encryption Using a Proposed W-Method Based on AES and DES Algorithms
Authors: Shukur Wisam Abed , Qurban Luheb Kareem , Aljuboori Ahmed
Published: January 2023

This paper proposes a new encryption method. It combines two cipher algorithms, i.e., DES and AES, to generate hybrid keys. This combination strengthens the proposed W-method by generating high randomized keys. Two points can represent the reliability of any encryption technique. Firstly, is the key generation; therefore, our approach merges 64 bits of DES with 64 bits of AES to produce 128 bits as a root key for all remaining keys that are 15. This complexity increases the level of the ciphering process. Moreover, it shifts the operation one bit only to the right. Secondly is the nature of the encryption process. It includes two keys and mixes one round of DES with one round of AES to reduce the performance time. The W-method deals with Arabic and English texts with the same efficiency. The result showed that the proposed method performs faster and more securely when compared to standard DES and AES algorithms.
Preface to translation
Authors:   Institute of Philosophy, Russian Academy of Sciences, Kusenko Olga I.
Published: January 2023

In this article, we provide the first commented edition and translation of an important fragment from Vladimir Zabugin’s posthumous work “The History of the Christian Renaissance in Italy” (Milan, 1924). Zabugin was a Russian historian, philologist and thinker, who lived and worked in Italy in the first quarter of the 20th century. He made an important contribution to the history of ideas with his concept of “Christian Renaissance”, abolishing the postulated antithesis of the Middle Ages and Renaissance as well as the idea of the Renaissance as the revival of antiquity. A sudden death in a mountaineering accident in the Italian Alps prevented Zabugin from completing his outstanding monography: editing the text, compiling notes, bibliography, name index, the absence of which made it very difficult for specialists to refer to the text. That is because a special focus of the present article lies in commenting the fragment and guiding the reader through Zabugin’s key conceptional points. The presented fragment of the first chapter of the book sought to emphasize the continuity of classical and christian culture in Italian proto-Renaissance literature, philosophy, architecture, fine arts. Refering to the eve of the Renaissance (13th century), Zabugin clearly demonstrates how the Christian culture “imperat” here, and the pagan one “ministrat”.
“Atmosphere of Truth”: Models for History of Philosophy in Neo-Scholasticism and Neo-Thomism
Authors:   Saint-Petersburg State University of Veterinary Medicine, Savinov Rodion V.
Published: January 2023

The article shows the development of historical and philosophical problems in Neo-Scholasticism and Neo-Thomism. There are two key goals that authors of historical and philosophical models of the development of intellectual culture sought to solve: primarily, this is the legitimation of Scholasticism as a philosophical tradition, and secondly, its actualization in the context of the philosophical and theological discussions of their time. After the 1840s catholic intellectuals realized a gap to the medieval and post-medieval scholastic tradition, and their historical and philosophical research ceased to be a tool for legitimizing of interpretation of Thomism, which claims to be authoritative. Intervention of scholasticism into the problems of philosophy in the 19th century led to a determination of their relationship to Kant and post-Kantian projects of transcendental philosophy. As a result, Joseph Maréchal SJ formed a project of Transcendental Thomism: he moved from the strategy of legitimizing scholasticism through historical and philosophical material to the strategy of transformation of Thomism to form the program of Scholasticism that would correspond to the “Epoch of Criticism”.
Dionysus and the Overman. Two Characters in the Philosophy of F. Nietzsche
Authors:   Lomonosov Moscow State University, Smyshlyaeva Elena S.
Published: January 2023

The article attempts to reveal the mutual relations between: the figure of the Greek god Dionysus, inseparable companion of the philosopher throughout his work, and, in contrast, the somewhat mysterious figure of the overman, who burst like a meteor in the first pages of the book “Thus Spoke Zarathustra”. Genetically linked not only to Greek mythology but also to Schopenhauer’s will, Nietzsche’s Dionysus already in “The Birth of Tragedy” appears on the other side of good and evil and sanctions the supremacy of aesthetic values over moral values; in the middle stage of Nietzsche's work Dionysianism leads the philosopher to the idea of the eternal recurrence; finally, in the third stage Dionysus is drawn into a war with Christianity and is polemically sharpened in the formula “Dionysus Versus the Crucified”. At different stages of Nietzsche’s work almost all of his major philosophical ideas – except one – either derived directly from Dionysianism or were aligned with it. The image of the overman at the moment of its appearance was so out of the general picture of the philosopher's doctrine, that in the course of time he had to “correct” it. The overman loses his most outstanding, but, as it turned out, superfluous features in “Twilight of Idols”, “The Anti-Christian”, and “Ecce Homo”. Having lost interest in the idea of the overman, Nietzsche tries in his last works to structure and complete his philosophical doctrine, returning to Dionysus. By analysing his later works, the author hopes to draw the attention of researchers to these attempts of the philosopher.
On Ibn Rushd’s Interpretation of the Aristotelian Concept of the Unaffectability of the Intellect
Authors:   Institute of Oriental Studies, Russian Academy of Sciences, Efremova Natalia V.
Published: January 2023

This publication is an another one in a cycle of our translations done from the work of the prominent Arab Muslim philosopher Ibn Rushd (Averroes, 1126–1198) which is famous not only as the most fundamental interpretation of the Aristotel’s treatise “On the Soul” in the culture of classical Islam, but also for an original concept developed in it about a single intellect for all people (mononoism). In the first three fragments of the commentary to the opening part of chapter III.4 of this treatise (429a10–18), the analogy of thinking and feeling serves as the basis for the conclusion about the human mind as an unaffected recipient. The forward, notes, and appendix to the translation draw on relevant passages from the Ibn-Rushed’ Short and Middle commentaries to this Aristotel’s treatise, highlight the discussion in the research literature about the chronological sequence of the middle and major versions, note the most important exegetical innovations of these fragments, and set out some assumptions about their possible motives.
A Study on Implications of British Transport Police System
Authors:   Korean Association of Public Safety and Criminal Justice, Lim Chang-Ho
Published: January 2023

Today the changes of railway environment are further increasing the demand for railway policing. The South Korean Railway Police Force puts great efforts into protecting citizens’ lives and properties and maintaining order on trains and in train stations. In order for South Korean Railway Police Force to develop further from now on, it may be necessary to analyze the railway police system in advanced foreign countries and derive implications as many as possible for South Korean Railway Police Force. The purpose of this study is to analyse the organization and operation of the British Transport Police System and to derive the useful implications for the South Korean Railway Police. These implications will be helpful for further development of the South Korean Railway Police Force.
Among the advanced foreign railway police forces, the British Transport Police has jurisdictions over almost all railways in U.K, and the British Transport Police Authority(BTPA) has been established to oversee and maintain the efficient and effective police force of the British Transport Police. Regarding the British Transport Police, the management of the BTP by BTPA, the establishment of regular annual plans, the establishment of clear mission and vision system, and the systematic goals setting may give many implications for the South Korean Railway Police Force.
The emergent pattern of infant stage ocean warming in satellite measurements
Authors: Yang Hu , Lohmann Gerrit , Stepanek Christian , Wang Qiang , Huang Rui Xin , Shi Xiaoxu , Liu Jiping , Chen Dake , Wang Xulong , Zhong Yi , Yang Qinghua , Bao Ying , Müller Juliane
Published: January 2023

Satellite-observed sea surface temperature (SST) provides an unprecedented opportunity to evaluate the ongoing global warming and has recently reached a milestone of 40 years temporal coverage. One of the major warming patterns captured by satellites is relatively strong subtropical ocean warming across all ocean basins. This pattern was widely interpreted as a manifestation of the Pacific Decadal Oscillation, a natural climate variability. However, we find that the observed warming pattern, characterized by strong warming over the subtropical oceans and mild warming or even cooling over the subpolar oceans, is dynamically consistent with where the surface water converges and diverges. By comparing observations with paleo-reconstructions and simulated short-term and long-term SST response to CO2 forcing, we propose that the observed warming pattern is likely in a transient early warming stage constrained by background ocean circulation. In the long term, ocean warming at high latitudes is expected to exceed the temporally dominating subtropical ocean warming. The committed, but lagged, high-latitude ocean warming has potential to reshape the ocean-atmosphere circulation and threaten the stability of marine-terminating ice sheets.
Computational Network Analysis of Host Genetic Risk Variants of Severe COVID-19
Authors: Alsaedi Sakhaa B. , Mineta Katsuhiko , Gao Xin , Gojobori Takashi
Published: January 2023

Background: Genome-wide association studies have identified numerous human host genetic risk variants that play a substantial role in the host immune response to SARS-CoV-2. Although these genetic risk variants significantly increase the severity of COVID-19, their influence on body systems is poorly understood. Therefore, we aim to interpret the biological mechanisms and pathways associated with the genetic risk factors and immune responses in severe COVID-19. We perform a deep analysis of previously identified risk variants and infer the hidden interactions between their molecular networks through disease mapping and the similarity of the molecular functions between constructed networks. Results: We designed a four-stage computational workflow for systematic genetic analysis of the risk variants. We integrated the molecular profiles of the risk factors with associated diseases, then constructed protein-protein interaction networks. We identified 24 protein-protein interaction networks with 939 interactions derived from 109 filtered risk variants in 60 risk genes and 56 proteins. The majority of molecular functions, interactions and pathways are involved in immune responses; several interactions and pathways are related to the metabolic and cardiovascular systems, which could lead to multi-organ complications and dysfunction. Conclusions: This study highlights the importance of analyzing molecular interactions and pathways to understand the heterogeneous susceptibility of the host immune response to SARS-CoV-2. We propose new insights into pathogenicity analysis of infections by including genetic risk information as essential factors to predict future complications during and after infection. This approach may assist more precise clinical decisions and accurate treatment plans to reduce COVID-19 complications. tions. Following SARS-CoV-2 infection, host genetic variations contribute to the development of illnesses that require critical care or hospitalization [1, 2]. Genome-wide association studies (GWAS) have been conducted to identify and validate risk tergenic, intronic, and transcript variants that are distributed in 60 genes in the 64 host genome. We found two gene clusters that have an impact on severe outcomes
OSA remains a risk factor for cardiac events even in hypertensive patients under treatment: The UROSAH data
Authors: Yao Xiaoguang , Li Nanfang , Heizhati Mulalibieke , Wang Yingchun , Ma Yue , Wang Run , Zhang Delian , Luo Qin , Hu Junli , Wang Menghui , Zhu Qing
Published: January 2023

Objectives: Both obstructive sleep apnea (OSA) and hypertension are risk factors of cardiovascular diseases (CVDs). The study aimed to observe the effect of the coexistence of OSA and hypertension on CVDs and evaluate the impact of antihypertensive treatment on CVDs outcomes in this population.
Study Design: This is a retrospective cohortstudy.
Methods: Hypertensive patients who underwent polysomnography (PSG) test in Jan 2011 to Dec 2013 were enrolled. OSA was defined as apnea hypopnea index(AHI)≥ 5. Outcomes were extended major adverse cardiovascular and cerebrovascular events (MACCE), including the first occurrence of non-fatal myocardial infarction, non-fatal stroke, revascularization, cardiac rehospitalization due to unstable angina or heart failure and all-cause death. The effect of the coexistence of OSA and hypertension on MACCE was explored by Cox regression analysis.
Results: Overall, 415 individuals out of 3329 hypertensives experienced extended MACCE. At a median follow-up of 7.0 years, the incidence of extended MACCE was significantly higher in OSA group than in non-OSA group (hazard ratio [HR]: 1.59; 95% confidence interval [CI]:1.27-1.99; P<0.001). Totally, OSA patients had a 57% increased risk of cardiac events than subjects without OSA [HR(95%CI):1.57 (1.04-2.39), P=0.034] and the association did not change in further sensitivity analysis. Especially in uncontrolled hypertension, OSA showed a 93% increased risk of cardiac events compared to patients without OSA(P=0.036) .
Conclusion: OSA remains a risk factor of cardiac events, while the association between OSA and cardiac events would be attenuated by the pharmacological-induced blood pressure control.
Bacteria-loaded biochar for the immobilization of cadmium in a natural alkaline polluted soil
Authors: Yan Zhengjian , Wang Zitong , Si Guangzheng , Chen Guohui , Feng Tingting , Liu Chang’e , Chen Jinquan
Published: January 2023

The combination of biochar and bacteria is a promising strategy for the remediation of Cd-polluted soil. However, the synergistic mechanisms of biochar and bacteria for Cd immobilization remain unclear. In this study, the experiments were conducted to evaluate the effects of the combination of biochar and Pseudomonas sp. AN-B15, on Cd immobilization, soil enzyme activity, and soil microbiome. The results showed that biochar could directly reduce the motility of Cd by adsorption and formation of CdCO3 precipitates, thereby protecting bacteria from Cd toxicity in the solution. Moreover, bacterial growth further induces the formation of CdCO3 and CdS and enhances Cd adsorption by bacterial cells, leading to a higher Cd removal rate. Thus, bacterial inoculation significantly enhances Cd removal in the presence of biochar in the solution. Moreover, soil incubation experiments showed that bacteria-loaded biochar significantly reduced soil exchangeable Cd in comparison with other treatments by impacting soil microbiome. In particular, bacteria-loaded biochar increased the relative abundance of Bacillus, Lysobacter, and Pontibacter, causing an increase in pH, urease, and arylsulfatase, thereby passivizing soil exchangeable Cd and improving soil environmental quality in the natural alkaline Cd polluted soil. Overall, this study provides a systematic understanding of the synergistic mechanisms of biochar and bacteria for Cd immobilization in soil and new insights into the selection of functional strain for the efficient remediation of the contaminated environments by bacterial biochar composite.
Protocol for developing a dashboard for interactive cohort analysis of oral health-related data
Authors: Sharma Vinay , Cassetti Oscar , Winnning Lewis , Sullivan Michael O' , Crowe Michael
Published: January 2023

Background: A working knowledge of data analytics is becoming increasingly important in the digital health era. Interactive dashboards are a useful, accessible format for presenting and disseminating health-related information to a wide audience. However, many oral health researchers receive minimal data visualisation and programming skills. The objective of this paper is to demonstrate the development of an analytical, interactive dashboard, using oral health-related data from multiple national cohort surveys.
Methods: The flexdashboard package was used within the R Studio framework to create the structure-elements of the dashboard and interactivity was added with the Shiny package. Data sources derived from the national longitudinal study of children in Ireland and the national children’s food survey. Variables for input were selected based on their known associations with oral health. The data were aggregated using tidyverse packages such as dplyr and summarised using ggplot2 and kableExtra with specific functions created to generate bar-plots and tables.
Results: The dashboard layout is structured by the YAML (YAML Ain’t Markup Language) metadata in the R Markdown document and the syntax from Flexdashboard. Survey type, wave of survey and variable selector were set as filter options. Shiny’s render functions were used to change input to automatically render code and update output. The deployed dashboard is openly accessible at https://dduh.shinyapps.io/dduh/. Examples of how to interact with the dashboard for selected oral health variables are illustrated.
Conclusions: Visualisation of national child cohort data in an interactive dashboard allows viewers to dynamically explore oral health data without requiring multiple plots and tables and sharing of extensive documentation. Dashboard development requires minimal non-standard R coding and can be quickly created with open-source software.
Dynamic modeling and vibration response experiment of clamp-pipeline system with soft nonlinearity
Authors: Cao Yiming , Chen Weijiao , Ma Hui , Li Hui , Wang Bing , Tan Li , Wang Xin , Han Qingkai
Published: January 2023

As an important supporting component, metal rubber clamp often generates nonlinear force and brings complex dynamics to pipeline system. However, the nonlinear of metal rubber clamps in pipeline system has been rarely incorporated in the open research. Therefore, based on genetic algorithm and finite element method, a new nonlinear clamp model with four degrees of freedom is proposed by introducing identified nonlinear parameters. The nonlinear parameters are identified by genetic algorithm in which the objective function is the error between experiment and simulation, and the nonlinear clamp-pipeline model is verified by modal test and vibration response experiment under different boundary conditions. The results show the numerical results are basically consistent with the experimental results. Moreover, the effects of clamp nonlinear stiffness coefficient, nonlinear damping coefficient, and excitation amplitude on vibration response of pipeline system are analyzed. The developed model can consider the nonlinear effect of pipeline system, so as to predict the vibration response more accurately.
Functionalization of melamine sponge for the efficient recovery of Pt(IV) from acid leachates
Authors: Wu Zhaojiang , Lin Zheng , Wang Shengye , Yang Bo , KE XIAO
Published: January 2023

The recovery of platinum from industrial waste is of critical importance. Usually, the recovery method is to dissolve the solid waste with acid to form a solution where platinum mainly exists in the form of Pt(IV). Therefor, it is urgen to efficiently and selectively adsorb Pt(IV) ions from acid leachates. In this study, a highly efficient adsorbent was developed by grafting of carboxyl and amine groups onto melamine sponge with alginate-Ca and polyethylenimine-glutaraldehyde (ML/ACPG). Combination of SEM, FTIR and XPS showed that the ML/ACPG sponge had a tree structure and the amino, carboxyl and hydroxyl groups were successfully introduced. Maximum adsorption capacity of ML/ACPG sponge reached up to 101.1 mg/L at pH of 1 (optimum initial pH value). The Pt(IV) ions were readily desorbed (within 60–80 min) using 0.1 M HCl + 0.025 M thiourea solution. Desorption efficiency remained higher than 83.3% while adsorption capacity decreased by less than 6.0% after 5 cycles operation. The ML/ACPG sponge was stable in 3 M of HNO3, NaCl after shaking for 72 h at 300 rpm with mass loss less than 2.5%. The mechanism of Pt(IV) adsorption onto ML/ACPG sponge mainly involved coordination by electrostatic attraction and carboxyl groups by protonated amine groups. The above results confirmed that the ML/ACPG sponge has a good practical application potential for Pt(IV) recovery from acid leachates.
Copula Theory based Investigation of the Physical Layer Security Performances for Downlink Non-Orthogonal Multiple Access(NOMA) Channel with Dependent Fading Coefficients
Authors: fadafen faramarz ajami khales , Hodtani Ghosheh Abed
Published: January 2023

In wireless communications, it is often assumed that the channel coefficients are independent, while there physically exists correlations between them. In this paper, considering physical layer security in downlink NOMA channel with dependent coefficients, important wireless performances (the average secrecy rates (ASR) and the secrecy coverage regions (SCR) are investigated, by using Copula theory. Specifically, the effect of channel coefficients correlation on the performances is analyzed. Based on the results of mathematical investigations and numerical results, we found that the effect of correlations between channels can improve performances or be harmful.
A Case of Obstructing Bronchial Aspergillosis in a Patient Receiving Cytotoxic Chemotherapy and Inhaled Corticoid Therapy
Authors: Tsuneoka Yuki , Tanaka Kentaro , Shimauchi Atushi , Inoue Shigetomo , Yoneshima Yasuto , Ikegame Satoshi , Harada Eiji , Okamoto Isamu
Published: January 2023

Background: Among various types of aspergillosis, the clinical feature of patients with obstructive bronchial aspergillosis is still unclear. Originally it was reported it occurs not in severe immunocompromised patients such as acquired immunodeficiency syndrome (AIDS) or post organ transplantation, while recent reports have suggested that this disease could afflict patients seen in daily practice of pulmonary medicine.
Case presentation: We describe a case of 76 years old woman with obstructing bronchial aspergillosis. This patient presented to the hospital with a productive coughduring treatment for asthma and advanced lung cancer. Chest CT showed stenosis of the bronchial lumen. Bronchoscopy showed no recurrence of lung cancer, and aspergillus were found in the granulation tissue. Cough improved with debridement of the lesion by bronchoscopy and oral antifungal medication treatment.
Conclusion: Our review of previous case reports as well as this case revealed that obstructing bronchial aspergillosis might occur when patients hold several backgrounds inducing immunosuppression such as solid tumors under anticancer treatment, inhaled corticosteroids and aging. As such patients may have risk to progress to invasive aspergillosis, physicians need to keep in mind obstructing bronchial aspergillosis should be properly diagnosed for delivering them appropriate treatment.
Size matters - the impact of nucleus size on results from spatial transcriptomics
Authors: Mohammadi Elyas , Chojnowska Katarzyna , Bienkowski Michal , Kostecka Anna , Koczkowska Magdalena , Zmijewski Michal A , Jakalski Marcin , Ingelsson Martin , Filipowicz Natalia , Olszewski Pawel , Davies Hanna , Wierzbicka Justyna , Hyman Bradley T , Dumanski Jan P , Piotrowski Arkadiusz , Mieczkowski Jakub
Published: January 2023

Background: Visium Spatial Gene Expression (ST) is a method combining histological spatial information with transcriptomics profiles directly from tissue sections. The use of spatial information has made it possible to discover new modes of gene expression regulations. However, in the ST experiment, the nucleus size of cells may exceed the thickness of a tissue slice. This may, in turn, negatively affect comprehensive capturing the transcriptomics profile in a single slice, especially for tissues having large differences in the size of nuclei.
Methods: We applied Consecutive Slices Data Integration (CSDI) to unveil accurate spot classification and clustering, followed by the deconvolution of spatial transcriptomic spots in human postmortem brains. We integrated spatial transcriptomic profiles with single nuclei RNA-seq data. We used histological information as a reference, to asses cell identification.
Results: We observed significant improvement in cell recognition and spot classification. Apart from the escalated number of defined clusters representing neuronal layers, the pattern of clusters in consecutive sections was concordant only after CSDI. Additionally, the assigned cell labels to spots match the histological pattern of tissue sections after CSDI.
Conclusion: CSDI can be applied to investigate consecutive sections studied with ST in the human cerebral cortex, avoiding misinterpretation of spot clustering and annotation, increasing accuracy of cell recognition as well as improvement in uncovering the layers of grey matter in the human brain.
Genomic Analysis and Clinical Correlations of Non-Small Cell Lung Cancer (NSCLC) Brain Metastasis (BM)
Authors: Skakodub Anna , Walch Henry , Tringale Kathryn , Eichholz Jordan , Imber Brandon , Vasudevan Harish , Li Bob , Moss Nelson , Yu Kenny , Mueller Boris , Powell Simon , Razavi Pedram , Yu Helena , Reis-Filho Jorge , Gomez Daniel , Schultz Nikolaus , Pike Luke
Published: January 2023

Up to 50% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), yet the study of BM genomics has been limited by tissue access, incomplete clinical data, and a lack of comparison with paired extracranial specimens. Here we report a cohort of 233 patients with resected and sequenced (MSK-IMPACT) NSCLC BM and comprehensive clinical data. With matched samples (47 primary tumor, 42 extracranial metastatic), we showed CDKN2A/B deletions and cell cycle pathway alterations to be enriched in the BM samples. Meaningful clinico-genomic correlations were noted, namely EGFR alterations in leptomeningeal disease (LMD) and MYC amplifications in multifocal regional brain progression. Patients who developed early LMD frequently had uncommon, multiple, and persistently detectable EGFR driver mutations. The distinct mutational patterns identified in BM specimens compared to other tissue sites suggest specific biologic underpinnings of intracranial progression.
Coix: an underutilized functional food crop of Mizoram
Authors: SONI JEETENDRA KUMAR , Lalramhlimi B. , Kumar Amit , Navik Omprakash , Sailo Lalhruaitluangi , Doley S.
Published: January 2023

Coix (Coix lacryma-jobi) comes under underutilized crops as it is neither cultivated commercially on a large scale nor widely traded. The Northeastern region of India harbours a rich diversity of Coix. This crop has diverse varieties from food to ethnic ornaments worn by the Mizo people. The soft-shelled types (var ma-yuen), locally called ‘Mim’ have been an important cereal crop among the Mizo rural communities since a long time. The grains are highly nutritious and its exceptional medicinal aspects have been extensively researched. While the seeds of wild types (var lacryma-jobi) are excellent beads for ornamental purposes and are key components in making traditional head gear ‘Vakiria’ worn by Mizo ladies in festive occasions. It is recently gaining importance as a ‘functional food’, due to its rich source of nutrients and bioactive compounds. The grains of Coix are gluten free which benefit people with celiac disease. It is used for preparing flour, soups, porridge, gruels, salads, desserts, snack, wine, sweets, etc. It is found to have diuretic, anti-inflammatory, antidiarrheal, antioxidant, antipyretic, antiseptic, antispasmodic, analgesic, hypotensive, and sedative properties. Coix germplasm are rapidly disappearing from wild and jhum lands and without conservation a large population of genetic diversity will be lost from Northeast India. Mizoram also possesses a wide array of germplasm which could potentially contribute to research priorities due to the wide variability that exists in the region. However, the ignorance on nutritional value of the crop, lack of standard agronomic practice, unavailability of high yielding quality seeds and potential varieties suitable for Mizoram condition, processing infrastructures and marketing have diminished the interest of farmers in popularizing this crop. So, forty-four Coix genotypes were evaluated owing to their agronomic characteristics to identify stable and promising genotypes suitable for Mizoram condition. Based on stability analysis, two genotypes RJT-1 (39.74 q/ha) and RJT-2 (35.27 q/ha) were identified as most stable genotypes for seed yield and other yield-related traits under Mizoram condition. The high yielding unstable genotype like RJTGP-53 (58.43 q/ha) can be considered for use in crop improvement programme with the help of a stable genotypic background. In addition, the occurrence of invasive fall armyworm, Spodoptera frugiperda(J.E. Smith) on Coix was observed and the damage incidence ranged between 7.23 to 10.86% in the vegetative growth stages (45 to 75 days crop) from the last week of August to the end of September. To our best knowledge, this is the first report of fall armyworm occurrence on Coix crop from India.
Tough, rapid self-recovery and responsive organogel-based ionotronic for intelligent continuous passive motion system
Authors: Chen Yong-Mei , Tang Jie , He Yuan , Xu Dan , Zhang Weijie , Hu Yang , Song Heming , Zhang Yunxia , Yang Yang , Zhang Kai
Published: January 2023

Continuous passive motion (CPM) has become an adjunct therapy to the standard postoperative rehabilitation regimen of joint injuries for a long time. However, the ability to in real-time monitor leg bearing capacity and actual bending angle of knee joints is highly desired for the treatment strategies of personalized postoperative rehabilitation and telemedicine. Here we report a novel intelligent CPM system for personalized rehabilitation and telemedicine based on the flexible and versatile ionotronic that possesses excellent mechanical properties and brilliant environmental tolerance. Especially, the corresponding ionotronic responds fastly and shows excellent cycling stability for strain sensing, ensuring the detection of actual joint bending angle with a high sensitivity and reliability. An intelligent CPM system assembled with this ionotronic and a wireless transmitter was constructed, opening up a new horizon for developing digital intelligent medical that can remotely monitor the movement of hospitalized/at-home patients who use CPM for personalized postoperative rehabilitation.
The discriminative ability of FRAX and possible FRAX-based intervention thresholds in the Chinese population: a 10-year study
Authors: Liu Yangxiaoou , Sun Yan'ge , Ye Xiaohua , Yan Yan , Li Chao , Li Xinyi
Published: January 2023

Purpose
Our study aims to assess the performance of FRAX and explored possible Chinese-specific intervention thresholds.
Methods
Four hundred and sixty-nine participants were observed for 10 years. Using FRAX with bone mineral density (BMD), 10-year possibilities of hip fracture (HF) and major osteoporotic fracture (MOF) were calculated. New fractures were self-reported. Using the incidence of new fractures as the gold standard, discrimination of FRAX was analyzed by receiver operating characteristic (ROC) curve. We also found possible intervention thresholds by using the greatest Youden index.
Results
Forty-nine MOFs were self-reported, including 5 HFs. ROC analysis showed the area under the curve (AUC) for FRAX-based MOF probability was 0.683, and the cut-off value was 2.95%. The sensitivity was 59.2% and the specificity was 67.6%. For prediction of HF, the AUC for FRAX-based HF probability was 0.776, and the cut-off value was 0.45%. The sensitivity was 100% and the specificity was 44.6%.
Conclusion
FRAX with BMD has the ability to discriminate osteoporotic fractures. FRAX-based MOF probability of 2.95% and HF probability of 0.45% can be considered as possible intervention thresholds.
Carbon footprints of Chinese fund firms' equity portfolios
Authors: Jinglei Wang , Yu Xiang , Zhang Zengkai , Chen Danbo , Guan Dabo
Published: January 2023

Under the dual carbon goals in China, the transition to a net-zero carbon economy demands massive amounts of capital, which must be provided and facilitated by financial institutions. Yet there are no accurate, annual, publicly available disclosures of the carbon emissions embodied in investments, leaving Chinese financial institutions facing significant carbon risks. To bridge this gap, this study looked at data from China’s 105 fund firms to measure the CO2 emissions embodied in their equity investments and carbon intensities from 2010 to 2020. The findings show that total financed emissions have been on a continuous upward trend since 2015, with large-sized fund firms contributing most. The overall trend for carbon intensity metrics shows a reduction in exposure to carbon-intensive assets and an increase in carbon efficiency. It is therefore crucial to identify the drivers of financed emissions and explore the potential for carbon reduction. Our findings suggest that some fund firms have already shifted their capital allocations to decarbonize their investment portfolios. Divesting from high-carbon assets and turning to high-tech sectors can help reduce carbon risk exposures and improve carbon efficiency, which is crucial if China’s institutional investors are to achieve a low-carbon transition and long-term sustainable development.
Crystalline Sirolimus-Coated Balloon (cSCB) Angioplasty in an all-comers,patient population with stable and unstable coronary artery disease including chronic total occlusions: Rationale, methodology and design of the SCORE trial
Authors: Otto Sylvia , Díaz Victor Alfonso Jiménez , Weilenmann Daniel , Cuculi Florim , Nuruddin Amin Ariff , Leibundgut Gregor , Alfonso Fernando , Ahmad Wan Azman Wan , Pyxaras Stylianos , Rittger Harald , Steen Philip , Schulze Christian , Gaede Luise , Wöhrle Jochen , Rosenberg Mark , Waliszewski Matthias W.
Published: January 2023

Background
A decade ago, the iopromide-paclitaxel coated balloon (iPCB) was added to the cardiologist‘s toolbox to initially treat in-stent restenosis followed by the treatment of de novo coronary lesions. In the meantime, DES technologies have been substantially improved to address in-stent restenosis and thrombosis, and shortened anti-platelet therapy. Recently, sirolimus-coated balloon catheters (SCB) have emerged to provide an alternative drug to combat restenosis.
Methods
The objective of this study is to determine the safety and efficacy of a novel crystalline sirolimus-coated balloon (cSCB) technology in an unselective, international, large-scale patient population. Percutaneous coronary interventions of native stenosis, in-stent stenosis, and chronic total occlusions with the SCB in patients with stable coronary artery disease or acute coronary syndrome were included. The primary outcome variable is the target lesion failure (TLF) rate at 12 months, defined as the composite rate of target vessel myocardial infarction (TV-MI), cardiac death or ischemia-driven target lesion revascularization (TLR). The secondary outcome variables include TLF at 24 months, ischemia driven TLR at 12 and 24 months and all-cause death, cardiac death at 12 and 24 months
Discussion
Since there is a wealth of patient-based all-comers data for iPCB available for this study, a propensity-score matched analysis is planned to compare cSCB and iPCB for the treatment of de novo and different types of ISR. In addition, pre-specified analyses in challenging lesion subsets such as chronic total occlusions will provide evidence whether the two balloon coating technologies differ in their clinical benefit for the patient.
Trial registration number: ClinicalTrials.gov Identifier: NCT04470934
An improved bi-objective salp swarm algorithm based on decomposition for green scheduling in flexible manufacturing cellular environments with multiple automated guided vehicles
Authors: Zhou Binghai , Zhang Jihua
Published: January 2023

Energy-awareness in the industrial sectors has become a global consensus in recent decades. Green scheduling is acknowledged as an effective weapon to reduce energy consumption in the industrial sectors. Therefore, this paper is devoted to the green scheduling of flexible manufacturing cells (FMC) with auto-guided vehicle transportation, where conflict-free routing of the vehicles is considered. To deal with this problem, a bi-objective optimization model is proposed to achieve the minimization of the maximum completion time and the total energy consumption in an FMC. The studied problem is an extension of flexible job shop problem which is NP-hard. Thus, an improved bi-objective salp swarm algorithm based on decomposition (IMOSSA/D) is proposed and applied to the problem. The approach is based on the decomposition of the bi-objective problem. Salp swarm intelligence along with three stochastic-distribution-based operators are incorporated into the approach, to enhance and balance its exploring and exploiting ability. Computational experiments are performed to compare the proposed approach with two state-of-the-art algorithms. This study allows the decision makers to better trade-off between energy savings and production efficiency in flexible manufacturing cellular environment.
A 16-year retrospective study of vascular anomalies in the head and neck region
Authors: Leyman Bernard , Govaerts Dries , Dormaar Jakob Titiaan , Bila Michel , Coropciuc Ruxandra-Gabriela , Politis Constantinus
Published: January 2023

Many different disciplines are involved in the diagnosis and treatment of vascular anomalies. Although clear communication is paramount in a multidisciplinary approach, different classification systems and nomenclatures are still used today. The ‘International Society for the Study of Vascular Anomalies’ (ISSVA) is the classification most accepted in literature and is mainly based on the radiologic and clinical presentation. We aimed to review the clinical practice of diagnosis and treatment of vascular anomalies in the head and neck region in a university hospital, with special attention for the nomenclature. All patients with a vascular anomaly who presented at the department of oral and maxillofacial surgery were reviewed in a retrospective manner. The nomenclature, diagnostic process, lesion characteristics, treatment and outcome were investigated. The lesions were classified and if necessary reinterpreted according to the ISSVA classification. A total of 185 patients were identified, of which 12.4% (n = 23) had a congenital anomaly. The most common lesions were venous malformations (n = 47, 25.4%), followed by lobular capillary hemangiomas (n = 17, 9.2%). Hundred and one patients (54,6%) received treatment, of which 93 were treated surgically (92,1% of the treated patients). Endovascular treatment was considered in 41 patients but only performed in eight. The other patients had too superficial lesions, which implies a risk of necrosis, leaving scars in the face. The histology report is a source of miscommunication, as clinicians use the ISSVA classification, while pathologists use the WHO classification. We found that both nomenclatures and classifications are used interchangeably in the clinical reports. The most used treatment modality remains surgery, notwithstanding the rise of minimally invasive techniques.
Magnetic flux leakage testing method for Ferromagnetic workpiece with rough surface based on the ferromagnetic lift-off layer
Authors: Yang Yun , Qiu Shaoxiong , Peng Guang , Liang Zhenyu , Kang Yihua
Published: January 2023

Conventional leakage detection studies usually consider the surface of the workpiece to be smooth by default. The lifting medium between the sensor and the workpiece is often a non-ferromagnetic material such as air; however, the surface roughness of the latter often affects the sensitivity of leakage detection in practical applications. To address these problems, this study proposed a magnetic leakage detection method based on the influence of surface roughness on the leakage field of surface cracks on the workpiece. The influence of the characteristic parameters of magnetic media on the leakage field signal of rough surface cracks was analyzed through simulations, and subsequently verified via experiments. The experimental results confirmed that the magnetic flux leakage detection method based on magnetic lift-off layer improved the signal-to-noise ratio (SNR) of the magnetic flux leakage signal of cracks on a rough workpiece surface. An increase in thickness (0.5 mm) and permeability of the magnetic media layer also improved the SNR (by 2.2 dB) of the magnetic flux leakage detection signal. Thus, the proposed method can improve the SNR of the leakage detection signal in general, which is expected to provide a certain reference value for leakage detection of rough surface workpieces.
Human Health risk assessment associated with the consumption of oysters ( Crassostrea gasar ) in Paranaguá Estuarine System/Brazil and its Salinity gradient as a tool to understand the contaminants assimilation dynamic.
Authors: Lima Leonardo Silva , Vieira Khauê Silva , Delgado Jéssica Freitas , Neto José Antônio Baptista , Fonseca Estefan Monteiro
Published: January 2023

Mollusks are considered one of the main bioindicators of pollution in aquatic environments, however, they are also the basis of food for several communities around the world. In estuaries such as the one monitored in this study, Paranaguá Estuarine Complex, where salinity variation is a relevant point, the bioaccumulation of metals (Al, As, Mn, Ni, Cu, Zn and Cd) in Crassostrea gasar oysters was identified in 5 different locations. Additionally, human health risk indexes were calculated from the concentration of metals found in oysters. Oysters were collected from 5 sampling stations along Paranaguá Estuarine System, close to oyster producing communities, natural banks used for extraction and containing large human populations, with potential for high environmental pollution. The oysters (C. gasar) proved effective in the environmental monitoring of these pollutants and emphasized the need for constant monitoring of the estuary, especially regarding As and Zn.
Establishment of the Rapid Propagation System of Actinidia arguta
Authors: Yao Wantian , Kong Lingling , Lei Diya , Zhao Bing , Tang Honglan , Zhou Xuan , Lin Yuanxiu , Zhang Yunting , Wang Yan , He Wen , Li Mengyao , Chen Qing , Luo Ya , Wang Xiaorong , Tang Haoru , Zhang Yong
Published: January 2023

The effects of different growth regulator types and ratios on the induction of adventitious shoots and adventitious roots were investigated using Actinidia arguta leaves as materials. 'Purple Sadova' was found to have strong germination and the highest germination rate on induction media with different PGRs concentrations. In this experiment, the best medium for the induction of adventitious shoots was MS + ZT 3.0 mg·L− 1 + NAA 0.1 mg·L− 1, with a germination rate of 36.67%. The most suitable site for the induction of adventitious shoots was the base of the leaves, with a germination rate of 80.00%. The longer the dark culture time was, the more suitable for adventitious bud germination, and the germination rate of adventitious buds reached 80.00% after 30 d of dark culture. The best proliferation medium for adventitious buds was MS + 6-BA 1.0 mg·L− 1+NAA 0.3 mg·L− 1, with a proliferation coefficient of 3.57. The proliferated buds had strong growth potential, large leaves, green color and high buds. The best rooting medium was 1/2MS + IBA 0.7 mg·L− 1, with 100% rooting rate, average root length of 2.81 cm and average root number of 14.5. In conclusion, this study explored an effective method to improve the quantity and quality of reproduction of this A. arguta, enriched the fast breeding system of A. arguta, and provided a theoretical basis for the factory breeding of all-red type A. arguta seedlings.
Differential change in indigenous versus endemic plant cover over time in an invaded Hawaiian landscape
Authors: Hibit Joshua , Daehler Curtis C.
Published: January 2023

Endemic island plant species under threat due to anthropogenic activities may be more susceptible to decline than their indigenous counterparts. Our study aimed to determine whether endemic and indigenous plant cover in Hawaiian forests have been differentially affected by resource availability, disturbance, and invasion over time. We resurveyed 25 plots (400 m2 each) across gradients of elevation, precipitation, slope, and understory light availability in forested conservation areas on the island of Oʻahu, Hawaiʻi, USA. We assessed how these abiotic factors relate to absolute cover (previous, current, and change over time) of endemic and indigenous Hawaiian plants, as well as that of non-native species. Endemic species had a net loss of cover (-45%) since previous surveys 27 to 45 years earlier, while indigenous species had a net gain (+ 29%), as did non-natives (~ 1%). Endemic species cover was associated with higher elevations in both prior surveys and in 2018, and with steeper plot slopes in prior surveys. However, change in endemic cover over time was negatively correlated with slope, likely due to landslide disturbance or the proliferation of shade-tolerant invaders in low-light conditions where no disturbance was evident. Change in endemic species cover over time was not clearly related to resource availability (light and precipitation). Given the differences in responses of endemic and indigenous species to abiotic conditions, and that the endemic species in this study were more susceptible to decline than indigenous species, the results of this study indicate that generalizations about natives as a single group can be misleading.