bluuebunny/crossref_metadata_2025 huggingface dataset:
Medical Students Perception about the Donation and Transplantation of Organs and Tissues
Authors: Garcia Catharine Conceição Martinez , Morbeck Cassio Augusto Estrela , Batista Cláudia Bacelar
Published: December 2022

Objective: To evaluate medical students’ perception about organ and tissue donation and transplantation. Methods: This is a cross-sectional study, with quantitative analysis, which evaluated students from the 1st to the 12th semester of the Bahia Medical School of the Bahia Federal University (FMB/UFBA), grouped by year of graduation (1st to 6th year), through a questionnaire. Data were statistically analyzed using R for Windows, considering significant values of p ≤ 0.05. Results: Of the 393 participants, 207 (52.7%) were female, 250 (63.3%) were between 21 to 25 years old, 144 (36.6%) had no religion, and 80 (20.3%) were boarding students. Of all the interviewees, 159 (40.5%) self-assessed their knowledge as regular and 153 (38.8%) as bad and terrible. About the exposure to the subject, 222 (56.6%) had never attended a class and, among those who had, 187 (60.1%) evaluated the information as insufficient. A total of 324 students (82.4%) would have the intention of being a post-mortem donor and 42 (61.6%) would accept to participate in a living donor transplantation, although 245 (62.3%) said they did not know the risks. Among the students, 327 (83.2%) said they knew the concept of brain death, 119 (30.3%) the legal terms of donation, and 105 (26.7%) the donor maintenance measures. However, 72 (18.3%) said they had a good knowledge of how to diagnose brain death. A total of 275 (70%) got right what is needed to declare a donor. There were 359 answers that would exclude alcoholics, smokers and users of illicit drugs from the transplant list, and 363 (92.7%) considered that the severity of the problem is the most appropriate criterion for priority on the waiting list. Conclusion: Students perceive their level of knowledge as unsatisfactory and understanding about specific issues is still low. No significant influence of sociodemographic aspects was observed regarding the desire to be a donor.
Influência de Fatores Clínicos e Psicossociais na Aceitação de Órgãos não Humanos em Transplantes: Xenotransplantes
Authors: Pavan Cinthia Laureano , Godoy Moacir Fernandes de , Miyazaki Eliane Tiemi , Silva Rita de Cassia Martins Alves da , Goes Caio Hussid de , Castiglioni Lilian , Silva Renato Ferreira da
Published: December 2022

Introdução: Xenotransplante é definido como o transplante de células, órgãos e tecidos entre diferentes espécies. É estudado como método alternativo para suprimento de órgãos humanos, cujo desequilíbrio na oferta e demanda resulta em alta mortalidade na fila espera de transplantes. O objetivo do presente estudo foi aprofundar o conhecimento sobre os aspectos psicossociais que influenciam na aceitação ou recusa do xeno-órgão, buscando agregar as informações que contribuam para as decisões dos pacientes. Métodos: Foi realizado um estudo observacional transversal a partir de relatos sobre a percepção de potenciais receptores de transplante hepático atendidos no centro de referência de um hospital universitário. Dois grupos de pacientes foram selecionados para o estudo:50 pacientes submetidos a transplante hepático (grupo transplante = TxG) e 50 candidatos a transplante (grupo pacientes em lista de espera = PLE). Todos receberam um questionário que aborda os aspectos psicossociais que os levaram a formar suas opiniões sobre o xenotransplante. Para comparar osgrupos, foram utilizados testes paramétricos e/ou não paramétricos, de acordo com a natureza dos dados, bem como testes de associação. Resultados: Entre os entrevistados, 91 (91%), sendo 46% no TxG e 45% no PLE acreditam que os xenotransplantes seriam benéficos para os pacientes em lista de espera e não houve diferença significativa entre os dois grupos estudados (p = 0,8418); 63 (63%) afirmaram que a religião influenciou suas opiniões; 74 (74%) afirmaram que suas experiências pessoais, principalmente em relação ao sofrimento gerado por suas doenças de base, influenciaram na forma como responderam ao questionário. Conclusão: A aceitação do xenotransplante é alta entre os grupos estudados, e a doença avançada em conjunto com suas complicações contribuem para aaceitação dessa modalidade de tratamento, tanto em pacientes já transplantados quanto naqueles que estão em lista de espera. A religião influenciou positivamente na aceitação do xeno-órgão.Nenhum dos fatores sociais e demográficos medidos obteve p ≤ 0,05, ou seja, relevância estatística, quando correlacionado como um fator para a decisão de aceitar um xeno-órgão. Os poucos pacientes que rejeitaram essa técnica alegaram que a falta de informações sobre o assunto influenciou em suas decisões. Os resultados obtidos indicam uma alta aceitação de xenoenxertos entre os gruposestudados, e que a divulgação de informações sobre os benefícios do xenotransplante pode contribuir para aumentar a receptividade dos pacientes em relação a este procedimento, ampliando seu potencial como solução para a escassez de órgãos humanos.
Monitorização Ambulatorial da Pressão Arterial no Diagnóstico e Manejo da Hipertensão após o Transplante Renal
Authors: Paes Fernando José Villar Nogueira , Albuquerque Francisco Daniel Alves , Maciel Valdimir Ferreira , Abreu José Sebastião de , Costa Silvana Daher da , Esmeraldo Ronaldo de Matos , Sandes-Freitas Tainá Veras de
Published: December 2022

Objetivo: Avaliar o comportamento da pressão arterial (PA) à monitorização ambulatorial da pressão arterial (MAPA) em receptores de transplante renal (TxR) estáveis, confrontando seus achados com as aferições manuais. Método: Estudo transversal incluindo 44 receptores de TxR de hospital público quaternário, com função renal estável, entre o 3o e 6o mês pós-TxR. Análises de concordância entre medida convencional e MAPA foram realizadas considerando dois limites de normalidade: limites I: PAambulatorial < 130/80 mmHg e PA média total à MAPA < 125/75 mmHg; limites II: PA ambulatorial < 140/90 mmHg e PA média total à MAPA < 130/80 mmHg. Resultados: Predominaram homens (54,5%) com idade média de 44 anos, em uso de anti-hipertensivos (75%). A prevalência de hipertensão arterial sistêmica (HAS) mascarada considerando os limites I foi de 15,9% quando comparada à aferição mais próxima à MAPA, e 31,8% quando confrontada com a média das três aferições prévias à MAPA.Considerando os limites II, a HAS mascarada ocorreu em 22,7% quando comparada com a aferição mais próxima à MAPA e em 38,6% quando se utilizou a média das aferições.Comprometimento do descenso noturno ocorreu em 40 (90,9%) pacientes. Considerando a MAPA como padrão-ouro, a acurácia da aferição manual mais próxima à monitorização foi de 72,7% para limites I. Quando considerada a média das aferições, a acurácia foi de 56,8% para os mesmos limites. A acurácia de acordo com os limites II foi 68,2% e 54,6% para a medida mais próxima à MAPA e para a média das aferições, respectivamente. Houve pobre concordância diagnóstica entre MAPA e medidas ambulatoriais (Kappa = 0,095 a 0,374). Os valores dos coeficientes lineares (R) para pressões sistólicas foram 0,609 e 0,671 para primeira aferição mais próxima à MAPA e para a média das aferições, respectivamente. Tais coeficientes para pressões diastólicas foram 0,521 e 0,454, respectivamente. Conclusão: Houve baixa concordância entre as aferições manuais e a MAPA, especialmente quanto à PA diastólica. A maioria dos pacientes apresentou descenso noturno alterado. Esses dados indicam a utilidade da MAPA na abordagem da HAS dessa população, além de oferecer informações adicionais quanto ao comportamento circadiano da PA.
Foreign Direct Investment di 3 Negara Asia Tenggara Periode 2005 – 2020
Authors: Azzahra Maryam Rifa
Published: December 2022

Investasi merupakan salah satu indikator terpenting dari pembangunan suatu negara, karena investasi dapat meningkatkan arus kas, menstabilkan perekonomian negara, terutama di negara-negara berkembang seperti Indonesia, Malaysia dan Thailand. Penelitian ini bertujuan untuk menganalisis pengaruh  inflasi dan nilai tukar terhadap Foreign Direct Investment (FDI) di 3 Negara Asia Tenggara yaitu Indonesia, Malaysia dan Thailand selama tahun 2005 - 2020. Data yang digunakan adalah data sekunder yang diperoleh dari website Bank Dunia. Data dianalisis menggunakan model regresi data panel. Hasil penelitian menemukan bahwa inflasi berpengaruh positif dan signifikan terhadap investasi asing langsung, sedangkan nilai tukar memiliki tidak memiliki pengaruh yang signifikan.
Pengaruh Indeks Persepsi Korupsi, Inflasi dan Nilai Tukar terhadap Investasi Asing Langsung di ASEAN-5
Authors: Purnama Muhammad Cahya
Published: December 2022

Penelitian ini bertujuan untuk menganalisis pengaruh indeks persepsi korupsi (CPI), inflasi, dan nilai tukar terhadap investasi asing langsung (FDI) di ASEAN-5. Data yang digunakan adalah data sekunder time-series periode 2005-2021, yang bersumber dari Transparency International dan World Bank. Data dianalisis dengan menggunakan regresi data panel. Hasil penelitian menunjukkan bahwa secara simultan CPI, inflasi dan nilai tukar berpengaruh signifikan terhadap FDI di ASEAN-5. Secara parsial CPI dan nilai tukar berpengaruh signifikan terhadap FDI di ASEAN-5, sedangkan inflasi tidak berpengaruh signifikan.
Pengaruh Produk Domestik Bruto dan Ekspor Terhadap Foreign Direct Investment di Indonesia, Thailand, dan Vietnam
Authors: Kirana Yeremia Sahat
Published: December 2022

Penelitian ini bertujuan untuk menganalisis pengaruh Produk Domestik Bruto (PDB) dan ekspor  terhadap Foreign Direct Investment (FDI) di Indonesia, Thailand, dan Vietnam. Penelitian ini menggunakan analisis panel data dengan mengkombinasikan data dari runtut waktu (2006-2020)  dan data cross section (tiga negara). Data diperoleh dari publikasi Badan Pusat Statistik dan World Bank. Hasil penelitian menunjukkan bahwa PDB dan ekspor memiliki pengaruh positif dan signifikan terhadap FDI di Indonesia, Thailand, dan Vietnam.
Low serum osteopontin levels in individuals with choroid plexus calcification
Authors: Yevgi Recep , Bilge Nuray , Şimşek Fatma , Ceylan Mustafa , Kotan Dündar Dilcan , Kızıldağ Nazım
Published: December 2022

Background & Objective: The choroid plexus (CP) is a tissue plexus located in the ventricles that produces hormones and nutrients, primarily cerebrospinal fluid (CSF). CP is also an important component of the blood CSF barrier. Osteopontin (OPN) is an extracellular matrix protein that plays a role in various physiological and pathological conditions such as bone reshaping, wound healing, vascular disorders, and inflammatory diseases. It is considered that OPN physiologically regulate bio- mineralization in bone tissue and reduce the growth and accumulation of calcium crystals in epithelial tissues. In our study, the role of OPN in CP calcification was studied.
Methods: A total of 90 people, without any disease but with CP calcification (45 people) and age and gender matched control without CP calcification (45 people) were studied. Calcified and normal CP tissue was identified in brain computed tomography (CT) images. Serum OPN levels were measured in individuals with and without CP calcification using a human OPN enzyme-linked immunosorbent test kit (ELISA) from morning fasting venous blood samples.
Results: Serum OPN level was found to be statistically significantly lower in patients with CP calcification than those without CP calcification (p=0.007).
Conclusions: Our results show that OPN may have a significant role in the calcification process of CP.
Efficacy and safety of intravenous thrombolysis in mild ischemic stroke
Authors: Hu Yinqin , Hu Fan , Li JunXiong , Xiao Qian , Hou YangBo , Chen Zhen , Cheng JiWei , Li GuoYi
Published: December 2022

Background: Intravenous thrombolysis is the preferred clinical treatment for ultra-early (<4.5 h) ischemic stroke. However, whether intravenous thrombolysis should be used in patients with mild stroke remains controversial. This study reports a systematic review and meta-analysis of the efficacy and safety of intravenous thrombolysis in acute mild stroke.
Methods: The PubMed, Cochrane Library, MEDLINE, Embase and CBM disc databases were searched for studies on intravenous thrombolysis versus nonthrombolysis in acute mild stroke. All studies published in English prior to March 2022 were retrieved. The studies were screened and selected based on the inclusion and exclusion criteria. Then, the data were extracted and recorded by trained researchers. RevMan 5.4 statistical software was used to analyze the data on the efficacy (mRS score, stroke recurrence rate and mortality at 90 days) and safety (intracranial hemorrhage, symptomatic intracranial hemorrhage) of the patients with acute mild stroke in the intravenous thrombolysis and nonthrombolysis groups.
Results: A total of 14 high-quality studies containing 86,063 patients with acute mild stroke (8,824 in the intravenous thrombolysis group; 77,239 in the nonthrombolysis group) were included in this meta-analysis. The meta-analysis results were as follows: (1) Efficacy: There were significant differences in mRS scores of 0~1 and 0~2 between the intravenous thrombolysis and nonthrombolysis groups (mRS 0-1, OR= 1.53, 95% CI: 1.31~1.79, Z=5.40, P <0.00001; mRS 0-2, OR= 1.33, 95% CI: 1.07~1.65, Z=2.59, P =0.01). (2) Safety: There was no significant difference in the recurrence rate of stroke or mortality between the two groups ( recurrence rate, OR= 0.62, 95% CI: 0.35~1.08, Z=1.68, P =0.09; mortality, OR=0.89, 95% CI: 0.45~1.77, Z=0.33, P =0.74). There were more patients with intracranial hemorrhage in intravenous thrombolysis group than in nonthrombolysis group (asymptomatic intracranial hemorrhage, OR= 2.39, 95% CI:1.19~4.80, Z=2.45, P =0.01; symptomatic intracranial hemorrhage, OR= 7.65, 95% CI:3.07~19.05, Z=4.37, P <0.0001).
Conclusion: Intravenous thrombolysis significantly improved the functional outcomes but did not reduce mortality at 90 days in patients with acute mild stroke and had a higher risk of intracranial hemorrhage.
Positive sharp waves and fibrillation potentials in polio survivors with sequelae: Are they due to late deterioration or radiculopathy?
Authors: Buturak Şencan , Fi̇danci Halit
Published: December 2022

Background & Objective: Needle electromyography (EMG) abnormalities can be observed in clinically affected or unaffected muscles in polio survivors. The primary aim of this study is to evaluate the positive sharp waves (PSWs) and fibrillation potentials (FPs) that can be observed in polio survivors. In addition, the presence of post-polio syndrome and radiculopathy was investigated in patients with PSWs/FPs.
Methods: Clinical features and needle EMG findings of polio survivors with sequelae who applied to our neurophysiology laboratory between August 2018 and January 2021 were analyzed retrospectively. Cervical and lumbosacral magnetic resonance imaging (MRI) of polio survivors with PSWs/FPs were included in the analyses. In addition, polio survivors were divided into groups with and without post-polio syndrome.
Results: Fifty-one polio survivors (33 male, 18 female) were included in the study. The mean age of the patients was 49.5±7.5 years. There were 13 (25.5%) polio survivors with post-polio syndrome. Needle EMG findings of 590 muscles were analyzed. PSWs/ FPs were found in 11 medial gastrocnemius, four iliopsoas, four tibialis anterior, two vastus lateralis muscles, and one deltoid muscle. PSWs or FPs were present in 12 (23.5%) of patients. PSWs/FPs were present in three (23.1%) and nine (23.7%) polio survivors with and without post-polio syndrome, respectively (p>0.05). Of the 12 patients with PSWs/FPs, 11 had cervical and lumbosacral MRIs. In eight (72.7%) of these 11 patients with PSWs/FPs, the nerve segment of the muscle with PSWs/FPs and the segment of radiculopathy detected by MRI were compatible with each other.
Conclusions: This study indicated that PSWs/FPs may be present in polio survivors. PSWs/FPs may be due to radiculopathy and/or late deterioration. It was concluded that PSWs/FPs are not a parameter that can be used to differentiate polio survivors with and without post-polio syndrome.
Isolated medial rectus paralysis caused by oculomotor dorsolateral nucleus infarction
Authors: Wang Zhifei , Li Shunlan , Lin Xue
Published: December 2022

Isolated internal rectus palsy secondary to midbrain infarction is extremely rare and mainly involves the internal rectus subnucleus of the oculomotor nerve. The subnucleus rectus motor neurons of the oculomotor nerve are composed of two independent regions, the dorsolateral nucleus and the ventral nucleus ventral. In the present case, a 44-year-old man developed isolated medial rectus palsy due to an oculomotor dorsolateral nucleus infarction. The presenting symptom was simple diplopia without other stroke manifestations. A 30-day follow-up visit was conducted, the symptom was alleviated completely. It was suggested that diplopia due to unilateral and isolated dorsolateral medial rectus nucleus paralysis may be the sole manifestation of midbrain infarction.
Can neurophysiology and nerve ultrasound differentiate acute-onset CIDP from GBS with treatment-related fluctuations?
Authors: Toh Tsun Haw , Shahrizaila Nortina , Yahya Mohd Azly , Goh Khean-Jin , Tan Cheng Yin
Published: December 2022

Distinguishing acute-onset chronic inflammatory demyelinating polyneuropathy (A-CIDP) from Guillain- Barré syndrome (GBS) with treatment-related fluctuations (TRF) in the early phase of disease can be challenging. Although characteristic clinical features have been previously reported, there is limited data on neurophysiological features. We aim to identify the electrophysiological and ultrasonographic features that might help differentiate between these two conditions. Patients with GBS-TRF and A-CIDP were identified from an existing cohort of GBS patients presenting to University of Malaya Medical Centre, Kuala Lumpur, Malaysia from 2011 to 2020. The clinical, electrophysiological and nerve ultrasound data were recorded and analysed. Five GBS-TRF (mean age 42 ± 23 years) and five A-CIDP (mean age 66 ± 13 years) patients were included. The mean time to first neurological deterioration was longer in A-CIDP compared to GBS-TRF (11 ± 5 vs 5 ± 1 weeks, p=0.028). Based on two sets of nerve conduction studies (NCS), both GBS-TRF and A-CIDP patients fulfilled the electrodiagnostic criteria for demyelinating neuropathy. A-CIDP patients had more prolonged ulnar minimal F-wave latencies (40.8 ± 5.8 vs 28.6 ± 2.2 ms, p=0.020) and slower sural conduction velocities (26.3 ± 8.6 vs 41.4 ± 3.4 m/s, p=0.015) on NCS. Nerve ultrasound showed significantly larger cross- sectional area of ulnar nerve at the wrist (7 ± 2 vs 5 ± 1 mm2, p=0.037) and forearm (8 ± 1 vs 5 ± 1 mm2, p=0.025) in A-CIDP patients. The Ultrasound Pattern Sum Score-A was significantly higher in A-CIDP compared to GBS-TRF (10 ± 3 vs 5 ± 1, p=0.015). We found nerve electrophysiological and ultrasonographic features can be useful in differentiating between GBS-TRF and A-CIDP.
Clinical subtypes, seasonality, and short-term prognosis of Guillain-Barré syndrome in an Eastern city of Turkey
Authors: Kiraz Mustafa , Yılgör Abdullah , Milanlıoğlu Aysel , Çilingir Vedat , Çağaç Aydın , Özkan Sibel
Published: December 2022

Background & Objective: This study aimed to analyze the frequency Guillain-Barré syndrome (GBS) subtypes and their relationship with clinical characteristics, seasonal variations and early prognosis in Van City, Turkey.
Methods: Patients with GBS who were admitted between January 2007 and December 2017 and diagnosed with acute inflammatory demyelinating neuropathy (AIDP), acute motor axonal neuropathy (AMAN) or acute motor sensory axonal neuropathy (AMSAN) were reviewed. Demographics, season of clinical onset, history and type of preceding infection, the Hughes Disability Score (HDS) at admission and discharge were recorded.
Results: Of a total 100 patients, 51% was diagnosed with AIDP, 25% with AMAN and the remaining 24% with AMSAN subtype. The most common seasonal onset was during the spring (34%), followed by the fall (30%). The history of gastroenteritis (GE) was present in 26% of the patients and these patients were more likely to have AMAN and AMSAN subtypes. HDS on admission and at discharge were significantly higher in patients with AMAN and AMSAN compared to those with AIDP (p=0.003 and p<0.001, respectively). The most important predictor of poor outcome at discharge was HDS on admission explaining between 50% and 80% of the total variance.
Conclusion: There is a high prevalence of AMAN and AMSAN subtypes in Eastern region of Turkey. The history of GE, which is also commonly found in patients with GBS in this region, is more likely detected in patients with AMAN and AMSAN subtypes. Finally, clinical severity on admission is the most important contributor to clinical outcome at discharge.
Effect of collateral level in CT angiography on clinical prognosis in stroke patients treated with mechanical thrombectomy after six hours
Authors: Yildirim Serhan , Ozdemir Atilla Ozcan , Gurkas Erdem , Akpinar Cetin Kursat , Sarionder Gencer Elif , Aykac Ozlem , Gokce Mustafa
Published: December 2022

Objectives: Collaterals have an effect on the protection of penumbra tissue. We evaluated the effect of collaterals on single-phase computed tomography angiography (CTA) in patients with AIS treated with MT after 6 hours.
Methods: We evaluated patients with ICA or M1 segment of MCA occlusion, time of symptom-groin puncture >6 hours, having CTA before MT, modified Treatment In Cerebral Ischemia score (mTICI) 2b-3 recanalization after MT. Data of collateral levels, outcome measures, timings and other variables were collected from Turkish Interventional Neurology Database. The level of collaterals was assessed with modified Tan scale.
Results: A total of 57 patients were included in our study. The median age was 64[56.5-75] years. The median NIHSS score at onset was 15[12-17.5] points. A total of 33 (57.9%) patients had good collaterals on CTA. Hypertension (HT) and diabetes mellitus (DM) rates were increased in the poor collaterals group. NIHSS scores decreased at the 24th hour in both good and poor collaterals groups. Twenty-two (66.7%) patients in the good collaterals group and 11 (45.8%) patients in the poor collaterals group had good clinical outcomes. However, there was not a significant difference (p=0.174, OR: 2.364; 95% CI: 0.802-6.697). Mortality rates were different in both groups, but the difference was not found to be significant (5[15.2%] versus 8[33.3%], p=0.124, OR:0.357; 95% CI: 0.1-1.278).
Conclusion: Good collaterals on single-phase CTA was not associated with improved neurological outcomes in AIS patients treated after 6 hours.
A simple and rapid focal seizure screening tool in resource-limited setting
Authors: Schee Jie Ping , Fong Si Lei , Lim Kheng Seang , Ahmad Sherrini Bazir , Shanizan Nor Sharizna , Tan Chong Tin
Published: December 2022

Background & Objective: A substantial proportion of patients were managed by general clinicians in resource-limited settings. Therefore, we aim to develop a simple and rapid focal seizure screening tool that can assist non-neurologists in seizure classification.
Methods: We conducted a self-administered qualitative questionnaire study on seizure manifestation developed based on the validated comprehensive questionnaires by Reutens et al. for clinical diagnosis of seizures. Logistic regression analyses were conducted to determine the features of seizure which form the items of a focal seizure screening tool. A receiver operating characteristic (ROC) curve analysis was conducted to determine the optimal cut-off score.
Results: Among the 199 subjects, 145 (73%) had focal seizures. Three categories of symptoms, i.e., (i) aura (fear, déjà vu, and epigastric aura), (ii) unilateral motor phenomena, and (iii) oral automatism, are significantly associated with the diagnosis of focal seizure. The logistic regression model containing these 3 items / features was statistically significant, χ2 (3, N=199) = 22.93, p<0.001, and correctly classified 71.4% of cases. A focal seizure screening tool was developed by assigning a score of 1 to each category of symptoms. The area under the curve of ROC curve is 0.706 (95% CI: 0.629-0.783), p<0.001. A score of ≥2 is the most optimal cut-off with a sensitivity of 50.3%, specificity of 85.2%, positive predictive value (PPV) of 91.0%, and negative predictive value (NPV) of 41.8%.
Conclusion: A simple and rapid self-administered focal seizure screening tool was established with high specificity and PPV.
Prior statin use and intravenous thrombolysis in acute ischemic stroke: a meta-analysis of cohort studies
Authors: Nie Tian , Wei Wan , Jiang Minhai , Du Quan
Published: December 2022

Background: There is uncertainty whether prior statin use (PSU) influences the outcomes of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Therefore, we conducted a systematic meta-analysis of published clinical trials to evaluate whether statin use combined with IVT therapy may be useful and safe.
Methods: Electronic databases were searched for clinical trials that involved outcomes between PSU and nonstatin use (NSU) among stroke patients treated with IVT. Functional outcome measures were 3-month favorable outcome (modified Rankin scale [mRS] 0–2) and 3-month excellent outcome (mRS 0–1). Adverse outcome measures were 3-month all-cause mortality, intracranial hemorrhage (ICH) and symptomatic ICH (sICH). Data were extracted and used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) by Review Manager 5.4 software.
Results: Eleven studies, totaling 13,745 patients (2,957 for PSU and 10,788 for NSU), met the inclusion criteria. Compared with NSU, PSU was associated with excellent outcome (OR=0.78; 95% CI, 0.70–0.88; p<0.0001), ICH (OR=1.26; 95% CI, 1.07–1.47; p=0.005) and sICH (ORNINDS=1.32; 95% CI, 1.06–1.64; p=0.01), whereas favorable outcome (OR=1.08; 95% CI, 0.86–1.35; p=0.50) and mortality (OR=1.11; 95% CI, 0.97–1.27; p=0.15) showed no significant difference between PSU and NSU. However, after combining the available multivariable data, associations with neither excellent outcomes (adjusted OR=0.92; 95% CI, 0.79–1.07; p=0.28) nor adverse outcomes (ICH: adjusted OR=1.11; 95% CI, 0.96–1.29; p=0.16; sICH: adjusted ORNINDS=1.21; 95% CI, 0.95–1.56; p=0.13) was found.
Conclusions: PSU might neither positively nor negatively affect the outcomes of AIS patients treated by IVT.
Explore the molecular mechanism of controlled hypothermic surgery to promote autophagy and inhibit oxidative damage to reduce the damage of neurovascular unit barrier
Authors: Chen Lixiong , Wang Ming , Li Feng , Jia Pifeng
Published: December 2022

Background: Controlled hypothermia surgery is a method to lower the body temperature to a certain level in order to reduce the body’s metabolism and maintain or delay cell activity. Autophagy can antagonize the apoptotic effect of cells by promoting cell survival.
Methods: Normal and hypothermic cerebral ischemia models in mice were established. Nissl staining and HE staining were used to analyze the pathological damage characteristics of mouse brain tissue. Microplate reader was used to measure the activity of SOD, and the fluorescent probe DCFH-DA was used to detect the content of ROS. The brain tissue sections were stained with MDC to observe the characteristics of autophagy. The characteristics of autophagosomes were observed by TEM. Western blot analysis was used to determine the expression of related proteins in brain tissue. RT-PCR analysis was used to determine the mRNA expression of genes Bcl-2 and Bax in brain tissue.
Results: HE staining and Nissl staining indicated that controlled hypothermia effectively reduced pathological damage. The activity of SOD and the content of ROS indicated that LI group has the lowest degree of oxidative damage. MDC staining, TEM imaging and Western blot analysis showed that controlled hypothermia surgery also increased the content of autophagosomes, and then promoted autophagy and apoptosis. RT-PCR also showed that LI group has the highest Bax/Bcl-2 ratio.
Conclusion: Controlled hypothermia can protect brain tissue and reduces damage caused by cerebral ischemia by promoting cell autophagy.
USE OF GENE XPERT MTB/RIF ASSAY FOR DETECTING MYCOBACTERIUM TUBERCULOSIS AND RIFAMPICIN RESISTANCE
Authors: ULLAH U , MEHMOOD M , IRFAN M , RAZZQA MA , ATIF M
Published: December 2022

The current study was designed to assess the specificity and sensitivity of MTB/RIF assay for early detection of Mycobacterium tuberculosis and RIF resistance in smear-positive and smear-negative pulmonary and extrapulmonary samples. This retrospective study was conducted in Bakhtawar Amin Trust Hospital Multan from July 2021 to July 2022. Total 240 pulmonary samples (gastric fluid specimens, post-bronchoscopic sputum, bronchoscopic aspirate, bronchoalveolar lavage and sputum) and 170 extra-pulmonary samples (urine specimens, skin biopsy, pericardial fluid, cerebrospinal fluid, ascitic fluid, disc material, lymph node biopsy and pleural fluid) were collected. After culture growth and identification of species, drug susceptibility testing (DST) was done. All samples underwent Xpert MTB/RIF assay. A total of 240 pulmonary and 170 extra-pulmonary samples from 410 patients were collected. The mean age of the patients was 46.5 ± 10 years. Of 410 subjects, 100 had TB, and 310 had no evidence of TB. Of 100 TB patients, the specificity of the MTB/RIF assay was 100 % (100), sensitivity was 69% (69), PPV was 100% (100), and NPV was 91% (91). According to the MTB/RIF assay, 79 samples were RIF-susceptible, and 1 was RIFresistant; DST confirmed the results. MTB/RIF assay is a valuable tool for detecting Mycobacterium tuberculosis and rifampicin resistance. It is not technique sensitive and provides results in less than three hours.
Şemseddîn-i Sivâsî’nin Mevlîd’inde Hz. Peygamber’in Ontolojik Konumu ve Ahlâkî Yetkinliği
Authors: Çınar Fatih
Published: December 2022

Türk-İslâm geleneği içerisinde Hz. Peygamber’in ontolojik konumu, ahlâkî değeri ve ona duyulan sevgiyi ifade etmesi bakımından mevlîd geleneği büyük bir öneme sahiptir. Anadolu’da, bilhassa Sivas ve civarında yüzyıllardır okuna gelen mevlîd türü eserlerin başında Şemseddîn-i Sivâsî’nin Mevlîd’i gelmektedir. Sivâsî, bu eserinde, vahdet-i vücûd düşüncesi bağlamında Hz. Peygamber’in ontolojik konumunu ve ahlâkî yetkinliğini konu edinmiştir. Şemseddîn Efendi, nûr-i Muhammedî, ef’âl, sıfât ve Zât tecellîleri, Hakk’ın zuhuru, insana verdiği değer, mârifet telakkisi, Hz. Peygamber’in mucizeleri, onun nurunun her an zuhur ettiği yönündeki söylemi, nefis mertebelerini kat etmede Hz. Peygamber’in nûru ile seyrin önemine dair vurguları, mirâcın manevî boyutuyla ilgili aktardıkları, fenâ, bekâ, cem‘, fark, aşk, şevk gibi kavramlar çerçevesindeki değerlendirmeleriyle Hz. Peygamber’in ontolojik bakımdan konumuna ve Hak katındaki değerine dair fikirlerini serdetmiştir. Sivâsî, Kur’ân-ı Kerîm’de Hz. Peygamber’in değerine işaret eden bazı âyetleri aktarması, Hz. Peygamber’in sünnetine ittibânın önemini sıklıkla vurgulaması, iffetli, sadık, cömert ve güler yüzlü, dünya için kızmayan, sabırlı, özrü kabul eden, boş konuşmayan, az yiyen, hastayı ziyaret eden, alçak gönüllü, yetime sahip çıkan, az uyuyan, hilm, hayâ sahibi ve mütevekkil, ibadete düşkün ve savaş hukukuna riâyetkâr olması gibi sıraladığı ahlâk-ı Nebî tasvirleri ile onun insan-ı kâmil noktasında yetkin ahlâk sahibi oluşuyla ilgili düşüncelerini aktarmıştır. Makalede, Sivâsî’nin Hz. Peygamber’in rûhî ve fizikî yönleri arasında kurduğu denge göz önünde bulundurularak, Kur’ân ahlâkını temsil konumunda olan Hz. Peygamber’e dâir değerlendirmeleri, Mevlîd adlı eseri bağlamında ele alınmıştır. Sivâsî’nin Hz. Peygamber’e dair ontolojik ve ahlâkî değerlendirmelerinde vahdet-i vücûd düşüncesinin temsilcileri ve mevlîd müellifleri içerisinde etkilendiği bazı isimler üzerinde de durulmuştur.
Sinoplu Safâyî’nin Manzum İhlâs Sûresi Tefsiri
Authors: Çelik Ramazan
Published: December 2022

Kur’ân-ı Kerîm, klasik Türk edebiyatının temel kaynağı olduğu için birçok edebî türün ortaya çıkmasına vesile olmuştur. Şairler sûre, âyet ve kıssalardan ilham alarak çeşitli eserler kaleme almıştır. Fakat Kur’ân sûrelerinin doğrudan edebî metne dönüştürülmesi hususunda temkinli davranılmıştır. Bununla beraber, özellikle mutasavvıf kimliği olan bazı şairler; Yâsin, Mülk, İhlâs gibi sûreleri nazmen tefsir etmiştir. Sinoplu Safâyî Efendi bu şairlerdendir. XV. yüzyılın ilk çeyreği ile XVI. yüzyılın ilk çeyreğinde yaşamış Safâyî; denizcilik, gemicilik gibi faaliyetlerin yanında ilim, şiir ve tasavvuf âleminde de maruf bir kimliğe sahiptir. Muʿcizât-ı Ahmediyye’sinde bazı dinî konuları ve peygamber mucizelerini anlatmakla beraber İhlâs sûresinin manzum tefsirine de yer vermiştir. Tefsir-nâme olarak nitelenebilecek metinde sûrenin âyet, cümle ve kelimeleri sade bir üslupla izah edilmiştir. Sûrenin sebeb-i nüzûlü üzerinde durulmuş, çeşitli sahâbe ve âlimlerin görüşlerine yer verilmiştir. İhlâs sûresinin fazileti hakkında Buhârî, Müslim, Tirmizî gibi imamlardan hadisler nakledilmiştir. Bu çalışmada, edebiyatımızdaki manzum tefsir geleneği hakkında bilgi verilmiş, Safâyî’nin hayatı ve eserleri üzerinde durulmuş ve elli sekiz beyitlik bölümü sadece Muʿcizât-ı Ahmediyye mesnevîsinde bulunan İhlâs sûresinin manzum tefsiri, şekil ve muhteva özellikleri bakımından incelenip tefsir metninin çeviri yazısına yer verilmiştir. Bu vesile ile edebiyatımızda bilinen manzum tefsir örneklerine bir yenisi daha ilave edilmiştir.
Arabian Jazz: The Challenges of Being an Arab American
Authors: Alghofaili Sultan
Published: December 2022

This paper investigates how Arab-American literature depicted the challenges of being an Arab-American prior to the events of 9/11. It argues that before the terrorist attacks, the complications of being an Arab-American were not necssairly related to religion. This idea is studied through looking closely at Diana Abu-Jaber's novel Arabian Jazz (1993) where the novel’s main character Jemorah, the daughter of a Jordainian immigrant, finds herself in constant struggle to find a unique sense of identity. That is mainly caused by the fact that her identity is being torn apart between two conflicted worlds; while the first is limited to the constraints of her family and inside the home, the other is found everywhere where she needs to assimilate into the society where she lives in. To highlight the outcome of these conflicting worlds, the paper looks at W. E. B. Du Bois’ concept of double-consciousness where one’s sense of identity is always looked at through the eyes of others. The paper concludes that for the second generation of Arab-Americans, the sense of identity is lost between the insistence of the first generation to preserve their Arab heritage, and a white America where the customs, traditions, and values of this culture is regarded as outsider.
Relación entre un estilo de apego no seguro y una mayor incidencia de violencia de pareja en mujeres adultas residentes de Costa Rica
Authors: Brenes Peraza Daniela , Benavides Fernanda
Published: December 2022

La presente investigación busca analizar la relación entre los estilos de apego y la violencia de pareja en mujeres adultas residentes de Costa Rica. Se realizó una investigación cuantitativa, correlacional y transversal con una muestra no probabilística de 324 mujeres adultas con edades entre los 18 y los 67 años durante los meses de marzo y abril del 2019, utilizando la Escala de Evaluación del Apego en Adultos con Medidas Independientes y el Cuestionario de Violencia entre Novios (CUVINO). Los resultados evidenciaron que: (1) apego temeroso correlaciona de manera positiva con violencia por coerción, violencia sexual, de género, física, por desapego, por humillación y por castigo emocional. (2) Un apego preocupante correlaciona de manera positiva con todos los tipos de violencia planteados. (3) Un apego evitativo correlaciona de manera positiva con violencia por coerción, violencia sexual, de género, física, por desapego, por humillación y por castigo emocional. (4) Un apego seguro correlaciona de manera negativa con violencia por coerción, sexual, de género, por desapego, por humillación y por castigo emocional. Se establece que sí existe una relación entre un estilo de apego no seguro en mujeres adultas y la experiencia de mayores índices de violencia de pareja.
Practical skills of care for children with acute respiratory infection among mothers of children below 5 years in Tam Thanh commune, Vu Ban district, Nam Dinh province
Authors: Do Thi Hoa , Le Thanh Tung , Hoang Thi Van Lan , Hoang Thi Thu Ha
Published: December 2022

Objective: To examine mothers’ practical skills in caring for children with ARIs in Tam Thanh commune, Vu Ban district, Nam Dinh province.
Participants and methods: A cross-sectional descriptive study from September 2020 to June 2021 on 194 mothers with children under 5 years old in Tam Thanh commune, Vu Ban district, Nam Dinh province.
Results: Practical skills in caring for children with ARIs achieved an average score of 14.3 ± 5.2/28 points.and only 15.5% of mothers who achieved all 3 practical skills.In which, the temperature measurement technique had the average score of 6.3 ± 1.97/10 points and 43.8% of mothers who passed practice skills. There were 17.5% of mothers who properly dried their children’s armpits and 42.8% of mothers who checked the thermometer with the correct technique. The technique of applying warm compress to reduce fever for children had a low average score of 5.8 ± 1.86 per 9 points and 58.2% of mothers who passed the practice skill. 49% of mothers did the right thing when checking the temperature of the water before applying heat to the baby. 33% of mothers applied the towel in the correct procedure. The chest percussion technique had the lowest average score of 2.1 ± 2.38 per 9 points and 10.8% of mothers who passed the practice skill. The majority of mothers performed the correct posture when pacing the baby’s chest with a rate of 62.9%. However, only 15.5% of mothers performed the correct technique of patting and moving their hands on the baby’s back. Most mothers did not perform the steps of the vibrating procedure correctly.
Conclusion: Practical skills in measuring temperature, applying warm compresses to reduce fever, and patting the chest in the care of children with ARIs of mothers were still low.
Kreativitas Tata Cahaya Moderen Dalam Pertunjukan Wayang Kulit Bali Masa Kini
Authors: Sudiana I Ketut
Published: December 2022

The problem of puppet show lighting in the puppet show is a very important element to be carefully considered as it is a medium in projecting shadow puppets on the screen.Because lighting is very influential ( the result of the projected shadow)  that project the identity of Balinese leather puppet figures, which contain aesthetic and symbolic values. In principle, the use of lighting in puppet shows should be able to produce a high carrying capacity, not merely the modern practicality but it also able to illuminate   according to the form of puppets in a surreal form.It also supports the expected  dramatic atmosphere, such as scenery or background depiction,in order to anticipate the shift in the thoughts of contemporary puppet viewers who tend to be realists. In line with the objective of this research which is to produce the anatomical shape of Balinese Wayang Kulit with an ideal proportions of electric lighting. It also aims to produce a  scenery that is in accordance  to the style of Balinese Wayang Kulit which is not realistic. The method used is the Practice-based Research method , a  creating and studying works of art based method. This practice-can produce the ideal shape and anatomy of wayang and the harmony between scenery and wayang.
Strategi Pemerintah Desa Dalam Peningkatan Pendapatan Asli Desa Melalui Program Pengelolaan Air Bersih Di Desa Cikalong Kecamatan Cimaung Kabupaten Bandung
Authors: Ramadhan Akbar
Published: December 2022

Most of the people in Cikalong Village currently have difficulty getting clean water. Because the majority of them do not have a personal water source and depend on water sources managed by the village. Village Original Income is closely related to the management of village assets owned. In Cikalong Village itself, village assets are one of the village's original sources of income, one of which is the clean water management program, which is currently under construction. This clean water management program includes springs, buildings and equipment to support clean water. This research is a qualitative research, using strategy theory from Bintoro Tjokroamidjojo with variable goal setting, policy formulation, and operationalization. The results of this study indicate that the purpose of the clean water management program is to improve community welfare in the health sector, to meet community needs for access to clean water, and to increase Village Original Income. Then in the formulation of the policy, Cikalong Village Regulation Number 5 of 2021 concerning Clean Water Management became the legal basis for running this program. The Village Regulation regulates all matters relating to the clean water program. Then for operationalization, after the implementation of the clean water management program, there have been no complaints from the public regarding access to clean water. For plans for other villages to use water managed by Cikalong Village, this is a long-term development plan for Cikalong Village. Because more and more people use water, there will also be an increase in Village Original Income
Analisis Yuridis Terhadap Proses Pendaftaran Kapal Untuk Mewujudkan Kepastian Hukum Status Kapal Pada Kantor Kesyahbandaran Dan Otoritas Pelabuhan Khusus Batam
Authors: Aliatul Hana Nurul , Parameshwara Parameshwara , Fadlan Fadlan
Published: December 2022

This study aims to find out and analyze the implementation of ship registration to realize legal certainty on ship status, factors that become obstacles or obstacles during the ship registration process at KSOP Batam. This research uses empirical or sociological normative research methods (applied law research) which is basically a combination with a normative approach (legal research), namely legal research regarding the application or implementation of normative legal provisions (codification, laws or contracts) in action on every certain legal event that occurs in society and in order to obtain primary data through field research (research). The results of the study show that legal arrangements for ship registration in Indonesia are contained in several laws and regulations, namely the Criminal Code, Law Number 17 of 2008 concerning Shipping, especially in Part Six which regulates the Legal Status of Ships from Article 158 to Article 161. Besides that, regulated in several implementing regulations, namely Government Regulation Number 51 of 2002 concerning Shipping and Minister of Transportation Regulation Number PM 13 of 2012 concerning Ship Registration and Nationality. In general it can be said that ship registration is so that every ship can always be identified throughout its operational life, therefore any changes to the name, ownership, size and specifications, other signs of the ship must be honestly reported to the ship registration official at the place where the ship is registered
Reformasi Sistem Pelayanan Publik Melalui Mobile Jkn Di Bpjs Kesehatan Kota Padang
Authors: Dwi Finta Dea , Syamsir Syamsir , Putra Adriyan Dendi , Muhammad Fadel , Febrilia Irma , Cahyani Widya
Published: December 2022

Bureaucratic reform is a fundamental change in the paradigm and governance of Indonesian government. On the basis of the desire for bureaucratic reform, the government seeks to improve the bureaucratic process. However, especially with regard to BPJS Health, it is still not running as expected, such as BPJS Health services which are sometimes often crowded, queued, and convoluted. With reform, there is a great need for digitization through the JKN mobile application. This method and writing uses a qualitative approach. Qualitative writing uses descriptive data, namely in the form of written or spoken words from people and observable behavior. This research utilizes open interviews to examine and understand attitudes, views, feelings and behavior of individuals or groups of people. Padang City Health BPJS services through Mobile JKN are getting better. It looks like participants don't have to come and queue to go to the office, and through their cellphones, everything they want is in mobile JKN and at the same time within their grasp, but it's also undeniable that as long as using the application there are still problems but they can still be controlled. So the presence of a digital-based service system reform makes it easier for the community
Analisis Marketing 3.0 Sebagai Rekomendasi Peningkatan Kunjungan Unit Rawat Inap Di Rumah Sakit Islam Surabaya A. Yani
Authors: Atika Nurmawaddah Lia
Published: December 2022

Bor in the inpatient unit at Surabaya Islamic Hospital A. Yani is still very low (30%) compared to the target BOR according to the Ministry of Health of the Republic of Indonesia (60% – 85%) in the last 3 months. The purpose of this study was to analyze marketing 3.0 as a recommendation for increasing visits in the inpatient unit of Surabaya Islamic Hospital A.Yani. This research is a quantitative descriptive research with a cross-sectional approach.  Data taken in May – June 2022. The data used is primary data using a questionnaire in the form of GoogleForm. The population in this study was part of the inpatient unit patients at the Surabaya A. Yani Islamic Hospital, with a sample of 80 taken by simple random sampling. The results of this study show that A. Yani Islamic Hospital has sufficiently implemented marketing 3.0 well. The analysis on the results of the questionnaire obtained several recommendations for visiting inpatient units based on marketing 3.0. This marketing recommendation is expected to increase inpatient visits at the Surabaya A. Yani Islamic Hospital.
Analisis Yuridis Dimensi Pertanggungjawaban Hukum Atas Pembatalan Nikah Untuk Meneguhkan Kepastian Hukum
Authors: Muzahar Muzahar , Ida Ansharullah , Erniyanti Erniyanti
Published: December 2022

This study aims to find out and analyze the implementation of legal responsibility for marriage annulment in Decision Number: 245/Pdt.G/2021/PA.Btm. To find out and analyze Decision Number: 245/Pdt.G/2021/PA.Btm regarding legal liability for marriage annulment by the Religious Courts to strengthen legal certainty. This study uses a descriptive analytical research type method using an empirical juridical approach. The results of the study show that the implementation of legal responsibility for marriage annulment in Decision Number: 245/Pdt.G/2021/PA.Btm did not run optimally because the Respondent never attended the trial process and the Panel of Judges made a decision by granting the Petitioner's request with verstek, and declaring null and void The marriage of the Petitioner and Respondent was held on September 19 2020 before the Marriage Registrar of the Office of Religious Affairs (KUA). Analysis of Decision Number: 245/Pdt.G/2021/PA.Btm on legal responsibility for canceling marriages by the Religious Courts to confirm legal certainty, namely that the cancellation of marriages can be accounted for and realized to strengthen legal certainty. This is because the Petitioner in this case has fulfilled all the requirements specified for annulment of marriage. Apart from that, the annulment of the marriage which was granted by the Panel of Judges also provided a sense of justice for the Petitioner, who so far had the right to receive spiritual support but the Respondent as a married couple was unable to fulfill it. For this reason, it is recommended for couples who want to get married to be open to each other about each other's shortcomings. To parents to carefully consider every process of applying for an annulment of marriage, and try to maintain their children's household as best as possible and to the Panel of Judges to consider the decision as fair as possible and ensure the wishes of both parties