bluuebunny/crossref_metadata_2025 huggingface dataset:
A Derivative-Free MZPRP Projection Method for Convex Constrained Nonlinear Equations and Its Application in Compressive Sensing
Authors: Sulaiman Ibrahim Mohammed , Awwal Aliyu Muhammed , Malik Maulana , Pakkaranang Nuttapol , Panyanak Bancha
Published: August 2022

Nonlinear systems of equations are widely used in science and engineering and, therefore, exploring efficient ways to solve them is paramount. In this paper, a new derivative-free approach for solving a nonlinear system of equations with convex constraints is proposed. The search direction of the proposed method is derived based on a modified conjugate gradient method, in such a way that it is sufficiently descent. It is worth noting that, unlike many existing methods that require a monotonicity assumption to prove the convergence result, our new method needs the underlying function to be pseudomonotone, which is a weaker assumption. The performance of the proposed algorithm is demonstrated on a set of some test problems and applications arising from compressive sensing. The obtained results confirm that the proposed method is effective compared to some existing algorithms in the literature.
Numerical Simulation Analysis of Difference from a Radial Resistivity Testing Method for Cylindrical Cores and a Conventional Testing Method
Authors: He Jiahuan , Liu Tangyan , Wen Long , He Tingting , Li Min , Li Jin , Wang Li , Yao Xin
Published: August 2022

Rock resistivity is a major geophysical technical parameter in geological and geotechnical engineering, geothermal prospecting, and oil and gas exploration. Its accurate measurement is of great significance to achieve the goal of “carbon peak and carbon neutrality”. To solve anisotropic problems, a method to test the radial resistivity in cylindrical core samples has been proposed and has been deemed the universal method, as it has the virtues of no specially processed sample being needed and nondestructive testing. However, there is still a difference in the radial resistivities obtained from this method and another testing method that is commonly used for cuboid samples. Furthermore, the differences between these methods have not yet been made clear in China or elsewhere. Therefore, we compared the results of the above-two testing methods via numerical simulations after establishing the potential field distribution, and, in combination with their methodological principles, illustrated the differences between the resistivities determined in samples with distinct shapes obtained using the two testing methods, summarized the conditions when there was zero difference and considerable difference when using the two methods, and provided a theoretical basis for the reasonable selection of an appropriate method to test the resistivity anisotropy.
The Hematopoietic Effect of Ninjinyoeito (TJ-108), a Traditional Japanese Herbal Medicine, in Pregnant Women Preparing for Autologous Blood Storage
Authors: Fukuda Eriko , Misugi Takuya , Kitada Kohei , Fudaba Megumi , Kurihara Yasushi , Tahara Mie , Hamuro Akihiro , Nakano Akemi , Koyama Masayasu , Tachibana Daisuke
Published: August 2022

Background and Objectives: There are no reports showing the hematopoietic effect of TJ-108 on pregnant women. The aim of this study was to investigate the effect of TJ-108 on the hemoglobin and hematocrit levels, and white blood cell and platelet counts of pregnant women complicated with placenta previa who were managed with autologous blood storage for cesarean section. Materials and Methods: We studied two groups of patients who were complicated with placenta previa and who underwent cesarean delivery. Group A consisted of women who were treated with oral iron medication (100 mg/day), and Group B consisted of women who were treated with TJ-108 at a dose of 9.0 g per day, in addition to oral iron medication, from the first day of blood storage until the day before cesarean delivery. To evaluate the effect of TJ-108, the patients’ red blood cell (RBC); Hb; hematocrit (Ht); white blood cell (WBC); and platelet count (PLT) levels were measured 7 days after storage and at postoperative days (POD) 1 and 5. Results: The study included 65 individuals, 38 in group A and 27 in group B. At the initial storage, a 0.2 g/dL reduction in Hb levels was observed, as compared to the initial Hb levels, in the TJ-108 treated patients, whereas a 0.6 g/dL reduction in Hb levels was observed in the non-TJ-108 treated group. On the other hand, regarding the second and subsequent storages, no significant difference was found in the decrease in the Hb levels of both groups. Conclusions: This study is the first report showing the effect of TJ-108 on improving anemia in pregnant women, presumably by its boosting effect on myelohematopoiesis. Therefore, the combined administration of both iron and TJ-108 is effective as a strategy for pregnant women at a high risk of PPH due to complications such as placenta previa.
Dual-Energy CT-Based Bone Mineral Density Has Practical Value for Osteoporosis Screening around the Knee
Authors: Choi Keun Young , Lee Sheen-Woo , In Yong , Kim Man Soo , Kim Yong Deok , Lee Seung-yeol , Lee Jin-Woo , Koh In Jun
Published: August 2022

Introduction: Adequate bone quality is essential for long term biologic fixation of cementless total knee arthroplasty (TKA). Recently, vertebral bone quality evaluation using dual-energy computed tomography (DECT) has been introduced. However, the DECT bone mineral density (BMD) in peripheral skeleton has not been correlated with Hounsfield units (HU) or central dual-energy X-ray absorptiometry (DXA), and the accuracy remains unclear. Materials and methods: Medical records of 117 patients who underwent TKA were reviewed. DXA was completed within three months before surgery. DECT was performed with third-generation dual source CT in dual-energy mode. Correlations between DXA, DECT BMD and HU for central and periarticular regions were analyzed. Receiver operating characteristic (ROC) curves were plotted and area under the curve (AUC), optimal threshold, and sensitivity and specificity of each region of interest (ROI) were calculated. Results: Central DXA BMD was correlated with DECT BMD and HU in ROIs both centrally and around the knee (all p < 0.01). The diagnostic accuracy of DECT BMD was higher than that of DECT HU and was also higher when the T-score for second lumbar vertebra (L2), rather than for the femur neck, was used as the reference standard (all AUC values: L2 > femur neck; DECT BMD > DECT HU, respectively). Using the DXA T-score at L2 as the reference standard, the optimal DECT BMD cut-off values for osteoporosis were 89.2 mg/cm3 in the distal femur and 78.3 mg/cm3 in the proximal tibia. Conclusion: Opportunistic volumetric BMD assessment using DECT is accurate and relatively simple, and does not require extra equipment. DECT BMD and HU are useful for osteoporosis screening before cementless TKA.
Experimental Investigation on Ablation of 4H-SiC by Infrared Femtosecond Laser
Authors: Wang Lukang , Zhao You , Yang Yu , Zhang Manman , Zhao Yulong
Published: August 2022

Femtosecond laser ablation has become one of the important structural processing methods for the third-generation semiconductor material, silicon carbide (SiC), and it is gradually being employed in the manufacture of microelectromechanical systems and microelectronic devices. Experimental study has been performed on infrared single and multiple pulses (1035 nm) femtosecond laser ablation of SiC at various processing parameters. Diameters of laser ablation spots on 4H-SiC were measured to estimate the absorption threshold for material modification and structural transformation, which were 2.35 J/cm2 and 4.97 J/cm2, respectively. In the multiple-pulse scribing ablation for microgrooves, the ablation threshold dropped to 0.70 J/cm2 due to the accumulation effect when the effective pulse number reached 720. The calculated average of the thermally stimulated ablation depth of 4H-SiC is 22.4 nm, which gradually decreased with the raising of the effective pulse number. For obtaining square trenches with precise and controllable depths and a smooth bottom in 4H-SiC, the effects of processing parameters on the material removal rate and surface roughness are discussed. The ablation rate per pulse is almost constant, even if the effective pulse number varies. The reduction of laser spot overlapping ratio in x direction has a greater weakening effect on the material removal rate than that in y direction. The precise amount of material removal can still be controlled, while modulating the surface roughness of the ablated features by changing the hatch rotation angle. This research will help to achieve controllable, accurate, and high-quality machining results in SiC ablation, using infrared femtosecond laser.
Mechanical Characterization and Analysis of Different-Type Polyimide Feedthroughs Based on Tensile Test and FEM Simulation for an Implantable Package
Authors: Seok Seonho , Park HyungDal , Kim Yong-Jun , Kim Jinseok
Published: August 2022

This paper presents the mechanical behaviors of different types of polyimide feedthroughs that are frequently used for implantable polymer encapsulation. Implantable packages of electronic devices often comprise circuits mounted on printed circuit boards (PCBs) encapsulated in a biocompatible polymer material, with input/output feedthroughs for electrical interconnections. The feedthroughs are regarded as essential elements of the reliability of the package since they create inevitable interfaces with the encapsulation materials. Flexible materials are frequently used for feedthroughs owing to their ease of manufacturing; thus, their mechanical properties are crucial as they directly interact with parts of the human body, such as the brain and neurons. For this purpose, tensile tests were performed to characterize the mechanical properties of flexible PCBs (FPCBs) and photosensitive polyimides (PSPIs). Commercial FPCBs and homemade PSPIs of two different thicknesses were subjected to tensile tests for mechanical characterization. The FPCBs showed typical stress–strain curves, while the PSPIs showed brittleness or strain hardening depending on the thickness. The material properties extracted from the tensile tests were used for explicit modeling using the finite element method (FEM) and simulations to assess mechanical behaviors, such as necking and strain hardening.
Femtosecond Laser Fabrication of Submillimeter Microlens Arrays with Tunable Numerical Apertures
Authors: Yang Tongzhen , Li Minjing , Yang Qing , Lu Yu , Cheng Yang , Zhang Chengjun , Du Bing , Hou Xun , Chen Feng
Published: August 2022

In recent years, the demand for optical components such as microlenses has been increasing, and various methods have been developed. However, fabrication of submillimeter microlenses with tunable numerical aperture (NA) on hard and brittle materials remains a great challenge using the current methods. In this work, we fabricated a variable NA microlens array with submillimeter size on a silica substrate, using a femtosecond laser-based linear scanning-assisted wet etching method. At the same time, the influence of various processing parameters on the microlens morphology and NA was studied. The NA of the microlenses could be flexibly adjusted in the range of 0.2 to 0.45 by changing the scanning distance of the laser and assisted wet etching. In addition, the imaging and focusing performance tests demonstrated the good optical performance and controllability of the fabricated microlenses. Finally, the optical performance simulation of the prepared microlens array was carried out. The result was consistent with the actual situation, indicating the potential of the submillimeter-scale microlens array prepared by this method for applications in imaging and detection.
Structural Organization of Dibromodiazadienes in the Crystal and Identification of Br···O Halogen Bonding Involving the Nitro Group
Authors: Nenajdenko Valentine G. , Shikhaliyev Namiq G. , Maharramov Abel M. , Atakishiyeva Gulnar T. , Niyazova Aytan A. , Mammadova Naila A. , Novikov Alexander S. , Buslov Ivan V. , Khrustalev Victor N. , Tskhovrebov Alexander G.
Published: August 2022

Nitro functionalized dibromodiazadiene dyes were prepared and fully characterized including X-ray single crystal analysis. Electron deficient dibromodiazadienes were found to be able to act as donors of halogen bonding (XB), while the nitro group acted as an acceptor of the XB. Depending on the substituents, the Br···O XB competed with other weak interactions, and for some of the dyes, they even outcompeted the XB involving the nitro group. However, the nitro functionalized dibromoalkenes 6a and 10a, which had only the nitro moiety as the most plausible acceptor of the XB, reliably formed 1D chains via Br⋯O XB. Experimental work was supported by the DFT calculations and topological analysis of the electron density distribution within the framework of Bader’s theory (QTAIM method).
Synthesis and Stereochemical Characterization of a Novel Chiral α-Tetrazole Binaphthylazepine Organocatalyst
Authors: Summa Assunta , Scafato Patrizia , Belviso Sandra , Monaco Guglielmo , Zanasi Riccardo , Longhi Giovanna , Abbate Sergio , Superchi Stefano
Published: August 2022

A novel α-tetrazole-substituted 1,1′-binaphthylazepine chiral catalyst has been synthesized and its absolute configuration has been determined by DFT computational analysis of the vibrational circular dichroism (VCD) spectrum of its precursor. The VCD analysis, carried out through the model averaging method, allowed to assign the absolute configuration of a benzylic stereocenter in the presence of a chiral binaphthyl moiety. The 1,1′-binaphthylazepine tetrazole and the nitrile its immediate synthetic precursor, have been preliminarily tested as chiral organocatalysts in the asymmetric intramolecular oxa-Michael cyclization of 2-hydroxy chalcones for the synthesis of chiral flavanones obtaining low enantioselectivity.
Possibilities of Using Medicinal Plant Extracts and Salt-Containing Raw Materials from the Aral Region for Cosmetic Purposes
Authors: Nowak Izabela , Issayeva Akmaral , Dąbrowska Marta , Wawrzyńczak Agata , Jeleń Henryk , Łęska Bogusława , Abubakirova Azhar , Tleukeyeva Assel
Published: August 2022

The aim of this work was to study the possibility of using medicinal plants in combination with salt-containing raw materials from the Aral Sea region for cosmetic purposes. The chemical and mineralogical compositions of salts occurring in this region were studied for pharmacological and cosmetic purposes. The salt-containing raw materials were studied by X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The microflora of saline-containing raw materials and flora of the Zhaksy-Klych lake were studied. Fifty-six plant species were identified, of which 25% belong to the Asteraceae family, 32% were Poaceae, 22% were Amaranthaceae, and 21% were Tamaricaceae. Using the solid-phase microextraction (SPME) method and comprehensive two-dimensional gas chromatography–mass spectrometry, the composition of volatile compounds in such plant species as Artemisia alba L., Achilleamillifolium L., Eleagus commutate Bernh. Ex Rydb., Psoraleadrupacea Bunge, Artemisia cipa O. Vegd., Thymus vulgaris L., Morus alba L., Salvia pratensis L., Glycyrhizaglabra L., Tanacetum vulgare L., Polygonumaviculare L., Alhagipseudoalhagi Gagnebin and Peganumharmala L., chosen on the basis of their herbal components for future cosmetic products, was determined. In total, 187 different volatile compounds were found in the endemic plant species Glycyrrhizaglabra L., of which the following were dominant: 1,7-octadiene-3-, 2,6-dimethyl- with a peak area of 4.71%; caryophyllenes; bicyclo[7.2.0]4,11,11-trimethyl-8-methylene-, [1R-(1R*,4E,9S*)]—3.70%; bicyclo[2.2.1] heptane-2-1,7,7-trimethyl-,(1S)—3.46%; cyclohexanone, 5-methyl-2-(1-methylethyledene)-; 2-isopropyledene-5—2.97%; menthol; cyclohexanol, 5-methyl-2-(1-methylethyl)-; p-menthane-3-ol; menthol alcohol; and 2-isopropyl-5—2.08%. The remaining compounds were detected in amounts of less than 2.0%. Tests of seven cosmetic compositions developed on the basis of plant extracts and salt-containing raw materials revealed that three samples had a moisturizing effect. Launching the production of cosmetic products in the Aral region will not only reduce social tensions but also significantly improve the environmental situation in the region.
Fresh and Stored Sugar Beet Roots as a Source of Various Types of Mono- and Oligosaccharides
Authors: Gruska Radosław Michał , Baryga Andrzej , Kunicka-Styczyńska Alina , Brzeziński Stanisław , Rosicka-Kaczmarek Justyna , Miśkiewicz Karolina , Sumińska Teresa
Published: August 2022

Although sugar beets are primarily treated as a source of sucrose, due to their rich chemical composition, they can also be a source of other carbohydrates, e.g., mono- and oligosaccharides. The study focused on both fresh beet roots and those stored in mounds. Our studies have shown that, in addition to sucrose, sugar beet tissue also comprises other carbohydrates: kestose (3.39%) and galactose (0.65%) and, in smaller amounts, glucose, trehalose and raffinose. The acidic hydrolysis of the watery carbohydrates extracts resulted in obtaining significant amounts of glucose (8.37%) and arabinose (3.11%) as well as xylose and galactose and, in smaller amounts, mannose. An HPSEC liquid chromatography study of the molecular mass profile of the carbohydrate compounds present in the beet roots showed alongside the highest percentage (96.53–97.43%) of sucrose (0.34 kDa) the presence of pectin compounds from the araban group and arabinoxylooligosaccharides (5–9 kDa) with a percentage share of 0.61 to 1.87%. On the basis of our research, beet roots can be considered a potential source of carbohydrates, such as kestose, which is classified as fructooligosaccharide (FOS). The results of this study may be helpful in evaluating sugar beets as a direct source of various carbohydrates, or as a raw material for the biosynthesis of fructooligosaccharides (FOS) or galactooligosaccharides (GOS).
Exceptional Properties of Lepidium sativum L. Extract and Its Impact on Cell Viability, Ros Production, Steroidogenesis, and Intracellular Communication in Mice Leydig Cells In Vitro
Authors: Jambor Tomas , Zajickova Terezia , Arvay Julius , Ivanisova Eva , Tirdilova Ivana , Knizatova Nikola , Greifova Hana , Kovacik Anton , Galova Eliska , Lukac Norbert
Published: August 2022

The prevalence of reproductive dysfunction in males has risen in the last few years, and alternative therapies are gradually gaining in popularity. Our in vitro study aimed to evaluate the potential impact of Lepidium sativum L. on mice TM3 Leydig cells, concerning basal parameters such as cell viability, cell membrane integrity, and lysosomal activity, after 24 h and 48 h exposure. Moreover, reactive oxygens species generation, sex-steroid hormone secretion, and intercellular communication were quantified. In the present study, the microgreen extract from Lepidium was rich in ferulic acid, 4-OH benzoic acid, and resveratrol, with a significant antioxidant activity. The results showed that lower experimental doses (62.5–250 µg/mL) could positively affect the observed parameters, with significant differences at 250 µg/mL after 24 h and 48 h, respectively. Potential risks could be associated with higher concentrations, starting at 500 µg/mL, 1000 µg/mL, and 2000 µg/mL of Lepidium. Nevertheless, biochemical quantification indicated a significant antioxidant potential and a rich content of biologically active molecules at the applied doses, and time determined the intracellular response of the cultured model.
Laser Microdissection-Mediated Isolation of Butterfly Wing Tissue for Spatial Transcriptomics
Authors: Banerjee Tirtha Das , Tian Shen , Monteiro Antόnia
Published: August 2022

The assignment of specific patterns of gene expression to specific cells in a complex tissue facilitates the connection between genotype and phenotype. Single-cell sequencing of whole tissues produces single-cell transcript resolution but lacks the spatial information of the derivation of each cell, whereas techniques such as multiplex FISH localize transcripts to specific cells in a tissue but require a priori information of the target transcripts to examine. Laser dissection of tissues followed by transcriptome analysis is an efficient and cost-effective technique that provides both unbiased gene expression discovery together with spatial information. Here, we detail a laser dissection protocol for total RNA extraction from butterfly larval and pupal wing tissues, without the need of paraffin embedding or the use of a microtome, that could be useful to researchers interested in the transcriptome of specific areas of the wing during development. This protocol can bypass difficulties in extracting high quality RNA from thick fixed tissues for sequencing applications.
Visible and Near-Infrared Broadband Absorber Based on Ti3C2Tx MXene-Wu
Authors: Jia Yang , Wu Tong , Wang Guan , Jiang Jijuan , Miao Fengjuan , Gao Yachen
Published: August 2022

A high absorption broadband absorber based on MXene and tungsten nanospheres in visible and near-infrared bands is proposed. The absorber has a maximum absorption of 100% and an average absorption of 95% in the wavelength range of 400–2500 nm. The theoretical mechanism and parameter adjustability of the absorber are analyzed by FDTD solutions. The results show that the structural parameters can effectively adjust the absorption performance. The good absorption performance is due to the action of the local surface plasmon resonance coupling with the gap surface plasmon resonance and Fabry–Perot resonance. The simulation results show that the absorber is insensitive to the polarization and oblique incidence angle of incident light, and that high absorption and broadband can be maintained when the oblique incidence angle is up to 60°.
Physical Mechanisms of Intermolecular Interactions and Cross-Space Charge Transfer in Two-Photon BDBT-TCNB Co-Crystals
Authors: Lu Chen , Li Ning , Jin Ying , Sun Ying , Wang Jingang
Published: August 2022

Co-crystal materials formed by stacking different molecules with weak interactions are a hot research topic. In this work, we theoretically investigate the intermolecular interactions and charge transfer properties of the supramolecular BDBT-TCNB co-crystal (BTC). The π-π bonds, hydrogen bonds, and S-N bonds in the BTC bind the BDBT and TCNB molecules together to form a highly ordered co-crystal and lead to the co-crystal’s excellent two-photon absorption (TPA) properties. The intermolecular interactions of the BTC are discussed in detail by the independent gradient model based on Hirshfeld partition (IGMH), atoms in molecules (AIM), electrostatic overlay diagram, and symmetry-adapted perturbation theory (SAPT) energy decomposition; it is found that there is a strong interaction force along the stacking direction. The charge transfer properties of the one-photon absorption (OPA) and TPA of the BTC were investigated by charge density difference (CDD) and transition density matrix (TDM). It is found that the dominant charge transfer mode is the cross-space charge transfer along the stacking direction. Therefore, strong intermolecular interactions will promote intermolecular cross-space charge transfer. This work is of great significance for the design of organic optoelectronic supramolecular materials.
Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis
Authors: Dou Yuqi , Yu Xue , Luo Yuanli , Chen Botian , Ma Defu , Zhu Jing
Published: August 2022

Background: Numerous studies have investigated the effects of the supplementation of fructooligosaccharides (FOS) on the number of bacteria in the gut that are good for health, but the results have been inconsistent. Additionally, due to its high fermentability, supplementation of FOS may be associated with adverse gastrointestinal symptoms such as bloating and flatulence. Therefore, we assessed the effects of FOS interventions on the composition of gut microbiota and gastrointestinal symptoms in a systematic review and meta-analysis. Design: All randomized controlled trials published before 10 July 2022 that investigated the effects of FOS supplementation on the human gut microbiota composition and gastrointestinal symptoms and met the selection criteria were included in this study. Using fixed or random-effects models, the means and standard deviations of the differences between the two groups before and after the intervention were combined into weighted mean differences using 95% confidence intervals (CIs). Results: Eight studies containing 213 FOS supplements and 175 controls remained in this meta-analysis. Bifidobacterium spp. counts significantly increased during FOS ingestion (0.579, 95% CI: 0.444–0.714) in comparison with that of the control group. Subgroup analysis showed greater variation in Bifidobacterium spp. in adults (0.861, 95% CI: 0.614–1.108) than in infants (0.458, 95% CI: 0.297–0.619). The increase in Bifidobacterium spp. counts were greater in the group with an intervention duration greater than 4 weeks (0.841, 95% CI: 0.436–1.247) than an intervention time less than or equal to four weeks (0.532, 95% CI: 0.370–0.694), and in the group with intervention doses > 5 g (1.116, 95% CI: 0.685–1.546) the counts were higher than those with doses ≤ 5 g (0.521, 95% CI: 0.379–0.663). No differences in effect were found between FOS intervention and comparators in regard to the abundance of other prespecified bacteria or adverse gastrointestinal symptoms. Conclusions: This is the first meta-analysis to explore the effect of FOS on gut microbiota and to evaluate the adverse effects of FOS intake on the gastrointestinal tract. FOS supplementation could increase the number of colonic Bifidobacterium spp. while higher dose (7.5–15 g/d) and longer duration (>4 weeks) showed more distinct effects and was well tolerated.
Effects of Short-Acting Opioids on Intraocular Pressure during General Anesthesia: Systematic Review and Network Meta-Analysis
Authors: Huang Jian-You , Shih Ping-Cheng , Chen Chu-Ting , Lin Han-Yu , Chien Yung-Jiun , Wu Meng-Yu , Chen Chih-Hao , Chang Chun-Yu
Published: August 2022

Intraocular pressure (IOP) is crucial to the well-being of eyes. During anesthesia, the administration of succinylcholine and endotracheal intubation are associated with an increase in IOP, which may be attenuated by short-acting opioids. However, the drug of choice among the commonly used short-acting opioids is unclear. This study aimed to evaluate the effects of fentanyl, sufentanil, alfentanil, and remifentanil on IOP measured after the administration of succinylcholine and after endotracheal intubation in patients undergoing general anesthesia. Five databases were searched. Randomized controlled trials (RCTs) that compared short-acting opioids and reported at least one of the clinical outcomes of interest were included. Nine RCTs with 357 patients were included. Remifentanil (1 μg kg−1) more effectively alleviated the increase in IOP than the placebo after the administration of succinylcholine [mean difference (MD) of IOP, −3.64; confidence interval (CI), −5.47 to −1.81 and after endotracheal intubation (MD, −9.71; CI, −11.91 to −7.51). Remifentanil (1 μg kg−1) ranked the best in terms of both attenuating the increase in IOP after the administration of succinylcholine [surface under the cumulative ranking curve (SUCRA), 0.91; normalized entropy (NE), 0.47; and after endotracheal intubation (SUCRA, 0.89; NE, 0.54) among all of the treatments. Remifentanil (1 μg kg−1) should be considered the drug of choice in the circumstances where increased IOP is a great concern.
Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections
Authors: Mori Matteo , Stelitano Giovanni , Griego Anna , Chiarelli Laurent R. , Cazzaniga Giulia , Gelain Arianna , Pini Elena , Camera Marina , Canzano Paola , Fumagalli Andrea , Scarpa Edoardo , Cordiglieri Chiara , Rizzello Loris , Villa Stefania , Meneghetti Fiorella
Published: August 2022

Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of M. tuberculosis (Mtb) have developed resistance against most of the established anti-TB drugs, new therapeutic options are urgently needed. An attractive target for the development of new anti-TB agents is the salicylate synthase MbtI, the first enzyme of the mycobacterial siderophore biochemical machinery, absent in human cells. In this work, a set of analogues of 5-(3-cyanophenyl)furan-2-carboxylic acid (I), the most potent MbtI inhibitor identified to date, was synthesized, characterized, and tested to further elucidate the structural requirements for achieving an efficient MbtI inhibition and potent antitubercular activity. The structure–activity relationships (SAR) discussed herein evidenced the importance of the side chain linked to the phenyl moiety to improve the in vitro antimycobacterial activity. In detail, 1f emerged as the most effective analogue against the pathogen, acting without cytotoxicity issues. To deepen the understanding of its mechanism of action, we established a fluorescence-based screening test to quantify the pathogen infectivity within host cells, using MPI-2 murine cells, a robust surrogate for alveolar macrophages. The set-up of the new assay demonstrates significant potential to accelerate the discovery of new anti-TB drugs.
Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery
Authors: Kravanja Katja Andrina , Finšgar Matjaž , Knez Željko , Knez Marevci Maša
Published: August 2022

Various active compounds isolated from natural sources exhibit remarkable benefits, making them attractive for pharmaceutical and biomedical applications, such as antioxidant, antimicrobial, and anti-inflammatory activities, which contribute to the treatment of cardiovascular diseases, neurodegenerative disorders, various types of cancer, diabetes, and obesity. However, their major drawbacks are their reactivity, instability, relatively poor water solubility, and consequently low bioavailability. Synthetic drugs often face similar challenges associated with inadequate solubility or burst release in gastrointestinal media, despite being otherwise a safe and effective option for the treatment of numerous diseases. Therefore, drug-eluting pharmaceutical formulations have been of great importance over the years in efforts to improve the bioavailability of active compounds by increasing their solubility and achieving their controlled release in body media. This review highlights the success of the fabrication of micro- and nanoformulations using environmentally friendly supercritical fluid technologies for the processing and incorporation of active compounds. Several novel approaches, namely micronization to produce micro- and nano-sized particles, supercritical drying to produce aerogels, supercritical foaming, and supercritical solvent impregnation, are described in detail, along with the currently available drug delivery data for these formulations.
Therapeutic Drug Monitoring of Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor in Cystic Fibrosis: Where Are We Now?
Authors: Choong Eva , Sauty Alain , Koutsokera Angela , Blanchon Sylvain , André Pascal , Decosterd Laurent
Published: August 2022

Drugs modulating the cystic fibrosis transmembrane conductance regulator (CFTR) protein, namely ivacaftor, lumacaftor, tezacaftor, and elexacaftor, are currently revolutionizing the management of patients with cystic fibrosis (CF), particularly those with at least one F508del variant (up to 85% of patients). These “caftor” drugs are mainly metabolized by cytochromes P450 3A, whose enzymatic activity is influenced by environmental factors, and are sensitive to inhibition and induction. Hence, CFTR modulators are characterized by an important interindividual pharmacokinetic variability and are also prone to drug–drug interactions. However, these CFTR modulators are given at standardized dosages, while they meet all criteria for a formal therapeutic drug monitoring (TDM) program that should be considered in cases of clinical toxicity, less-than-expected clinical response, drug or food interactions, distinct patient subgroups (i.e., pediatrics), and for monitoring short-term adherence. While the information on CFTR drug exposure–clinical response relationships is still limited, we review the current evidence of the potential interest in the TDM of caftor drugs in real-life settings.
Einstein’s Elevator: World Lines, Michelson–Morley Experiment and Relativistic Paradox
Authors: Rouaud Mathieu
Published: August 2022

We all have in mind Einstein’s famous thought experiment in the elevator where we observe the free fall of a body, and then the trajectory of a light ray. Here, in addition to the qualitative aspect, the exact calculations are carried out, and the worldlines equations are given. A uniformly accelerated reference frame in rectilinear translation is considered, and it is shown that the trajectories of the particles are semi-ellipses with the center on the event horizon. The frame of reference is non-inertial, the spacetime is flat, and the computations are performed within the framework of special relativity. Some experimental consequences are discussed, especially the experiment with the accelerated Michelson–Morley interferometer is solved, and an experiment, where a new relativistic paradox appears—a particle of matter seems to go faster than light—is described. The differences, compared to the classical case, are important at a large scale and close to the horizon, but they are small in the lift where the interest is above all theoretical. The concepts of metric, coordinated velocity and horizon are discussed, and an analogy with the black hole is made.
Cryostructuring of Polymeric Systems: 62 Preparation and Characterization of Alginate/Chondroitin Sulfate Cryostructurates Loaded with Antimicrobial Substances
Authors: Vernaya Olga I. , Ryabev Andrey N. , Shabatina Tatyana I. , Karlova Daria L. , Shabatin Andrey V. , Bulatnikova Lyudmila N. , Semenov Alexander M. , Melnikov Mikhail Ya. , Lozinsky Vladimir I.
Published: August 2022

Targeted drug release is a significant research focus in the development of drug delivery systems and involves a biocompatible polymeric carrier and certain medicines. Cryostructuring is a suitable approach for the preparation of efficient macroporous carriers for such drug delivery systems. In the current study, the cryogenically structured carriers based on alginate/chondroitin sulfate mixtures were prepared and their physicochemical properties and their ability to absorb/release the bactericides were evaluated. The swelling parameters of the polysaccharide matrix, the amount of the tightly bound water in the polymer and the sulfur content were measured. In addition, FTIR and UV spectroscopy, optical and scanning microscopy, as well as a standard disk diffusion method for determining antibacterial activity were used. It was shown that alginate/chondroitin sulfate concentration and their ratios were significant factors influencing the swelling properties and the porosity of the resultant cryostructurates. It was demonstrated that the presence of chondroitin sulfate in the composition of a polymeric matrix slowed down the release of the aminoglycoside antibiotic gentamicin. In the case of the NH2-free bactericide, dioxidine, the release was almost independent of the presence of chondroitin sulfate. This trend was also registered for the antibacterial activity tests against the Escherichia coli bacteria, when examining the drug-loaded biopolymeric carriers.
Ecotoxicity Study of New Composite Materials Based on Epoxy Matrix DER-331 Filled with Biocides Used for Industrial Applications
Authors: Panda Anton , Dyadyura Kostiantyn , Valíček Jan , Harničárová Marta , Kušnerová Milena , Ivakhniuk Tatyana , Hrebenyk Liudmyla , Sapronov Oleksandr , Sotsenko Vitalii , Vorobiov Pavlo , Levytskyi Vitalii , Buketov Andriy , Pandová Iveta
Published: August 2022

The impact of fillers in the epoxy oligomer on the test culture of the marine ecosystem was investigated. The content of additive—biocides—was selected based on the complex research using STAT-GRAPHICS® Centurion XVI. The ecotoxicity of composite surfaces was determined in model systems using methods which are standard in eco-microbiology. The microorganism was identified by studying morphological, cultural, biochemical, and antigenic properties. Studies of the structure and the microrelief of the surfaces of composite materials were conducted using scanning electron microscopy (SEM) and X-ray energy dispersive spectroscopy. Based on comprehensive research, it was established that the composition of oxytetracycline with content of q = 1.5 wt% and nanosilver with a content of q = 0.075 wt% per 100 wt% of the DER-331 oligomer and 10 parts by the mass of the TETA hardener ensures the formation of a porous nano-heterogeneous structure of the coating, which leads to the acceleration of the release of silver ions from the surface of the polymer. The rational content of the complex additives of biocides ensures adhesion to the cell wall of bacteria with subsequent penetration into it and subsequent change to the cell membrane, its death, and, therefore, the suppression of the fouling process of metal structures.
Application of Nanomicelles in Enhancing Bioavailability and Biological Efficacy of Bioactive Nutrients
Authors: Li Lei , Zeng Yun , Chen Minyi , Liu Gang
Published: August 2022

Nutraceuticals provide many biological benefits besides their basic nutritional value. However, their biological efficacies are often limited by poor absorption and low bioavailability. Nanomaterials have received much attention as potential delivery systems of nutrients and phytonutrients for multiple applications. Nanomicelles are nanosized colloidal structures with a hydrophobic core and hydrophilic shell. Due to their unique characteristics, they have shown great perspectives in food and nutraceutical science. In this review, we discussed the unique properties of nanomicelles. We also emphasized the latest advances on the design of different nanomicelles for efficient delivery and improved bioavailability of various nutrients. The role of nanomicelles in the efficacy improvement of bioactive components from nutraceutical and health foods has been included. Importantly, the safety concerns on nano-processed food products were highlighted.
Traffic Flow Speed Prediction in Overhead Transport Systems for Semiconductor Fabrication Using Dense-UNet
Authors: Joo Young Ha , Park Hoonseok , Kim Haejoong , Choe Ri , Kang Younkook , Jung Jae-Yoon
Published: August 2022

To improve semiconductor productivity, efficient operation of the overhead hoist transport (OHT) system, which is an automatic wafer transfer device in a semiconductor fabrication plant (“fab”), is very important. A large amount of data is being generated in real time on the production line through the recent production plan of a smart factory. This data can be used to increase productivity, which in turn enables companies to increase their production efficiency. In this study, for the efficient operation of the OHT, the problem of OHT congestion prediction in the fab is addressed. In particular, the prediction of the OHT transport time was performed by training the deep convolutional neural network (CNN) using the layout image. The data obtained from the simulation of the fab and the actual logistics schedule data of a Korean semiconductor factory were used. The data obtained for each time unit included statistics on volume and speed. In the experiment, a layout image was created and used based on the statistics. The experiment was conducted using only the layout image without any other feature extraction, and it was shown that congestion prediction in the fab is effective.
Should the Use of Patient Medical Information in Research Require the Approval of Attending Physicians?
Authors: Nakazawa Eisuke , Maeda Shoichi , Udagawa Makoto , Akabayashi Akira
Published: August 2022

Retrospective observational studies using medical records require researchers to guarantee the right to opt out of the study. However, is it also necessary to confirm whether the medical professionals who created those medical records permit their use as well? In this article, we consider possible options based on a fictitious scenario. Based on our deliberations, we recommend that the information be disclosed on the hospital’s homepage or in leaflets (principal investigator: hospital director), and, similar to patients, attending physicians should be given the opportunity to opt out. We also recommend that an application be submitted to the hospital’s research ethics committee. In this paper, we address the public interest aspect of the use of patient information as a primary item for ethical scrutiny. In addition to research ethics, this particular point underscores the importance of public health ethics, particularly as they pertain to the conflict between individual freedom and public interest.
Offshore Bridge Detection in Polarimetric SAR Images Based on Water Network Construction Using Markov Tree
Authors: Liu Chun , Yang Jian , Ou Jianghong , Fan Dahua
Published: August 2022

It is difficult to detect bridges in synthetic aperture radar (SAR) images due to the inherent speckle noise of SAR images, the interference generated by strong coastal scatterers, and the diversity of bridge and coastal terrain morphologies. In this paper, we present a two-step bridge detection method for polarimetric SAR imagery, in which the probability graph model of a Markov tree is used to build the water network, and bridges are detected by traversing the graph of the water network to determine all adjacent water branch pairs. In the step of the water network construction, candidate water branches are first extracted by using a region-based level set segmentation method. The water network is then built globally as a tree by connecting the extracted water branches based on the probabilistic graph model of a Markov tree, in which a node denotes a single branch and an edge denotes the connection of two adjacent branches. In the step of the bridge detection, all adjacent water branch pairs related to bridges are searched by traversing the constructed tree. Each bridge is finally detected by merging the two contours of the corresponding branch pair. Three polarimetric SAR data acquired by RADARSAT-2 covering Singapore and Lingshui, China, and by TerraSAR-X covering Singapore, are used for testing. The experimental results show that the detection rate, the false alarm rate, and the intersection over union (IoU) between the recognized bridge body and the ground truth are all improved by using the proposed method, compared to the method that constructs a water network based on water branches merging by contour distance.
Crop Classification Based on GDSSM-CNN Using Multi-Temporal RADARSAT-2 SAR with Limited Labeled Data
Authors: Li Heping , Lu Jing , Tian Guixiang , Yang Huijin , Zhao Jianhui , Li Ning
Published: August 2022

Crop classification is an important part of crop management and yield estimation. In recent years, neural networks have made great progress in synthetic aperture radar (SAR) crop classification. However, the insufficient number of labeled samples limits the classification performance of neural networks. In order to solve this problem, a new crop classification method combining geodesic distance spectral similarity measurement and a one-dimensional convolutional neural network (GDSSM-CNN) is proposed in this study. The method consisted of: (1) the geodesic distance spectral similarity method (GDSSM) for obtaining similarity and (2) the one-dimensional convolutional neural network model for crop classification. Thereinto, a large number of training data are extracted by GDSSM and the generalized volume scattering model which is based on radar vegetation index (GRVI), and then classified by 1D-CNN. In order to prove the effectiveness of the GDSSM-CNN method, the GDSSM method and 1D-CNN method are compared in the case of a limited sample. In terms of evaluation and verification of methods, the GDSSM-CNN method has the highest accuracy, with an accuracy rate of 91.2%, which is 19.94% and 23.91% higher than the GDSSM method and the 1D-CNN method, respectively. In general, the GDSSM-CNN method uses a small number of ground measurement samples, and it uses the rich polarity information in multi-temporal fully polarized SAR data to obtain a large number of training samples, which can quickly improve the accuracy of classification in a short time, which has more new inspiration for crop classification.
A Multivariate Drought Index for Seasonal Agriculture Drought Classification in Semiarid Regions
Authors: Bageshree K. , Abhishek  , Kinouchi Tsuyoshi
Published: August 2022

Drought assessment in any region primarily hinges on precipitation deficiency, which is subsequently propagated to various components and sectors, leading to different drought types. In countries such as India, an intricate relationship between various governing factors, drought types, and their quantification methodologies make it elusive to timely initiate government relief measures. This also prevents comprehensive inclusion of the integrated effect of the principal drivers of drought, resulting in ambiguous categorization of severity, where groundwater storage variability is often neglected despite its significant role in irrigation. Here, we developed a multivariate Joint Drought Index (JDI) combining satellite and model-based standardized indices of precipitation and evapotranspiration (SPEI), soil moisture (SSI), groundwater (SGI), and surface runoff (SRI) with different temporal scales by employing two robust methods, principal component analysis (PCA) and Gaussian copula, and applied the index to highly drought-prone Marathwada region from central India. Our novel approach of using different scale combinations of integrated indices for two primary seasons (Kharif and Rabi) provides more realistic drought intensities than multiple univariate indices, by incorporating the response from each index, representing the seasonal drought conditions corroborating with the seasonal crop yields. JDI, with both methods, successfully identified two major drought events in 2015 and 2018, while effectively capturing the groundwater drought. Moreover, despite the high correlation between JDI using PCA and copula, we observed a significant difference in the intensities reported by these methods, where copula detected exceptional drought conditions more frequently than PCA. JDI effectively detected the onset, duration, and termination of drought, where the improved accuracy of drought detection can play a critical role in policy formation and socioeconomic security of the related stakeholders. Seasonal agriculture drought categorization for holistic quantification of drought conditions as presented in this study should provide broad methodological implications on drought monitoring and mitigation measures, especially for agriculture-dominated regions in semiarid climates.