bluuebunny/crossref_metadata_2025 huggingface dataset:
Landscape of Global Oncology Research and Training at National Cancer Institute–Designated Cancer Centers: Results of the 2018 to 2019 Global Oncology Survey
Authors: Abudu Rachel M. , Cira Mishka K. , Pyle Doug H.M. , Duncan Kalina
Published: November 2019

PURPOSE

The National Cancer Institute (NCI)–Designated Cancer Centers (NDCCs) are active in global oncology research and training, leading collaborations to support global cancer control. To better understand global oncology activities led by NDCCs, the NCI Center for Global Health collaborated with ASCO to conduct the 2018/2019 NCI/ASCO Global Oncology Survey of NDCCs.

METHODS

Seventy NDCCs received a two-part survey that focused on global oncology programs at NDCCs and non–National Institutes of Health (NIH)-funded global oncology projects with an international collaborator led by the NDCCs. Sixty-seven NDCCs responded to the survey. Data were coded and analyzed by NCI-Center for Global Health staff.

RESULTS

Thirty-three NDCCs (47%) reported having a global oncology program, and 61 (87%) reported a collective total of 613 non–NIH-funded global oncology projects. Of the NDCCs with global oncology programs, 17 reported that trainees completed rotations outside the United States and the same number enrolled trainees from low- and middle-income countries (LMIC). Primary focus areas of non–NIH-funded projects were research (469 [76.5%]) and capacity building or training (197 [32.1%]). Projects included collaborators from 110 countries; 68 of these were LMIC.

CONCLUSION

This survey shows that there is a substantial amount of global oncology research and training conducted by NDCCs and that much of this is happening in LMIC. Trends in these data reflect those in recent literature: The field of global oncology is growing, advancing scientific knowledge, contributing to building research and training capacity in LMIC, and becoming a recognized career path. Results of the 2018 Global Oncology Survey can be used to foster opportunities for NDCCs to work collaboratively on activities and to share their findings with relevant stakeholders in their LMIC collaborator countries.
Can a Mulatta Be a Black Jacobin?
Authors: Chetty Raj
Published: November 2019

This essay approaches the stage versions of Toussaint Louverture (1934) and The Black Jacobins (1967), first, to emphasize the role of C. L. R. James’s collaborations in the creation of the plays, and second, to argue that the latter version of the play presents a radical feminism that emerges precisely from these collaborations. One of the play’s most radical revisions is the centrality of the militant mulatta Marie-Jeanne, whose centrality challenges scholarly interpretations of James’s relationships with women and with feminism. This scholarship depicts James, at worst, as a paragon of patriarchy and, at best, as a man caught between the feminist politics of the women in his life and the constraints of a male-centered Caribbean revolutionary and anticolonial tradition. By contrast, this essay argues that the feminism in the play must be read beyond James the man and instead in the context of his collaborations, particularly with radical women thinkers.
Julián del Casal
Authors: Lima José Lezama
Published: November 2019

In 1941, a young José Lezama Lima, the Cuban poet, essayist, and novelist—who would go on to author the polemically erotic neobaroque masterwork Paradiso (1966) and essays on cultural expression in the Americas, such as “La expresión americana” (1957)—published an article in a Havana newspaper on the late-nineteenth-century queer Cuban modernista poet Julián del Casal that advocated for a decolonial poetics of reception and failure and a creative use of the artist’s archive. This is the first published English translation of Lezama Lima’s “Julián del Casal.”
Recent advances in the understanding and therapeutic management of mastocytosis
Authors: Rossignol Julien , Polivka Laura , Maouche-Chrétien Leila , Frenzel Laurent , Dubreuil Patrice , Hermine Olivier
Published: November 2019

Mastocytosis is a rare disease due to the abnormal accumulation of mast cells in various tissues. Its clinical presentation is heterogeneous depending on mast cell infiltration and mediators release. In some cases, it is associated with hematological malignancies. Prognosis varies from very good with a life expectancy similar to the general population in indolent forms of the disease to a survival time of just a few months in mast cell leukemia. Although in most cases a somatic KIT D816V mutation is found in tumor mast cells, the physiopathology of the disease is not yet fully understood. Additional germline and somatic mutations may explain this heterogeneity. Treatments aim at blocking effect of mast cell mediators, reducing mast cell activation and tumor burden. New drugs mainly directed against the tyrosine kinase activity of KIT have dramatically changed the quality of life and prognosis of mast cell diseases. Present and future therapeutic strategies are discussed in this review.
Recent advances in the understanding and management of ARDS
Authors: Peck Tyler J , Hibbert Kathryn A
Published: November 2019

The acute respiratory distress syndrome (ARDS) remains a common and highly morbid condition despite advances in the understanding and management of this complex critical illness. Recent work has illuminated the heterogeneity within ARDS and demonstrated the likely impact of heterogeneity on the identification of effective therapeutic interventions. Despite these challenges, new data have also informed the standard of care for ARDS and have resulted in the re-evaluation of previously established therapies, including ventilation strategies, pharmacologic interventions, and rescue therapies. As the field of ARDS continues to evolve, innovative approaches will be needed to further define phenotypes within ARDS and design targeted clinical trials.
Dental stem cells in tooth repair: A systematic review
Authors: Tawfik Tadros Mary Sabry , El-Baz Maha Abd-El Salam , Khairy Mohamed Adel Ezzat Khairy
Published: November 2019

Background: Dental stem cells (DSCs) are self-renewable teeth cells, which help maintain or develop oral tissues. These cells can differentiate into odontoblasts, adipocytes, cementoblast-like cells, osteoblasts, or chondroblasts and form dentin/pulp. This systematic review aimed to summarize the current evidence regarding the role of these cells in dental pulp regeneration.

Methods: We searched the following databases: PubMed, Cochrane Library, MEDLINE, SCOPUS, ScienceDirect, and Web of Science using relevant keywords. Case reports and non-English studies were excluded. We included all studies using dental stem cells in tooth repair whether in vivo or in vitro studies.

Results: Dental pulp stem cell (DPSCs) is the most common type of cell. Most stem cells are incorporated and implanted into the root canals in different scaffold forms. Some experiments combine growth factors such as TDM, BMP, and G-CSF with stem cells to improve the results. The transplant of DPSCs and stem cells from apical papilla (SCAPs) was found to be associated with pulp-like recovery, efficient revascularization, enhanced chondrogenesis, and direct vascular supply of regenerated tissue.

Conclusion: The current evidence suggests that DPSCs, stem cells from human exfoliated deciduous teeth, and SCAPs are capable of providing sufficient pulp regeneration and vascularization. For the development of the dental repair field, it is important to screen for more effective stem cells, dentine releasing therapies, good biomimicry scaffolds, and good histological markers.
Advancing good governance in data sharing and biobanking - international aspects
Authors: Fernando Buddhika , King Mandella , Sumathipala Athula
Published: November 2019

Ethical and effective data-sharing among countries can be achieved by considering the interests of all relevant parties: research participants, researchers and funders. Fears of exploitation, however, both of research participants and researchers from low- and middle-income countries (LMIC), can undermine the free flow of data necessary for scientific advancement.

In this Open Letter, two case studies presented at the 2018 Global Forum on Bioethics in Research meeting on the Ethics of data sharing and biobanking in Cape Town, South Africa, function as the focal point for a reflection on the attributes of an ideal model of good data governance and how it can help support ethical best practices in biobanking and data sharing.

Consideration of the case studies as well as the literature indicate three broad principles that need to be reflected in an ideal data governance framework: (i) collaboration - both among researchers as well as between researchers and participants, (ii) fairness – ensuring that all parties in international collaborations, the data provider, primary data gathering LMIC researcher and the high income country (HIC) institution/funder are treated fairly, and (iii) working towards a level playing field – neither collaboration nor fairness can be effectively achieved with the existing power differential between HIC and LMIC researchers/institutions; it is therefore necessary to work towards achieving a more level playing field between partners in research collaborations.

Promoting good governance of data through fair, efficient and accountable governance frameworks can help build trust and ensure continued international data sharing.
Does post-registration palliative care education for nurses improve practice? A systematic review
Authors: Thavaraj Angela , Gillett Karen
Published: November 2019

Aims:

We aimed to answer the question: what is the evidence that post-registration palliative care education for nurses improves practice?

Background:

The 2008 End of Life Care Strategy emphasised the need for a workforce equipped to provide high-quality end-of-life care for patients and their families. As registered nurses are the healthcare professionals spending most time with patients and families at the end of life, associated policy documents stress the importance of educating nurses to equip them with the necessary knowledge and skills to provide effective care. Despite education being a consistent recommendation, the ability of education to influence nursing practice is uncertain.

Methods:

We undertook a systematic review of literature using Joanna Briggs Institute Methodology for Mixed Methods by searching the Medline, Embase and CINAHL databases between January 2006 and December 2018.

Findings:

Ten studies met the inclusion criteria, seven contained quantitative data. Six demonstrated improvements in outcome measures, but not all results were statistically significant. Most quantitative data related to self-reported measures of confidence. Six studies contained qualitative findings that were categorised into themes: confidence, practice change, skills and proactivity.

Conclusion:

Little research exists exploring the impact of post-registration palliative care education for nurses. Existing outcome measures do not clearly demonstrate changes to end-of-life practice. Research is suggested to establish links between self-reported confidence and improvements to practice. Evaluation of the impact on practice should be an integral component of end-of-life education initiatives.
A nurse's journey through mental ill health
Authors: Fisher Jane
Published: November 2019

Jane Fisher, a community psychiatric nurse, describes her experience of perinatal mental health problems after the birth of her third child, the treatment and interventions she received from the health service and her personal journey to recovery
Flu vaccinations for staff: Regulatory considerations
Authors: Cowan Kate
Published: November 2019

With flu vaccination season upon us, you may be considering providing vaccinations to your practice staff. Kate Cowan, Advisory Case Manager at Medical Protection, looks at the key indemnity and regulatory issues to consider
Health and wellbeing in general practice
Authors: McCutcheon Jonathan
Published: November 2019

In this article, Jonathan McCutcheon looks at the impact of health and wellbeing on the role of a practice manager and what support can be accessed
District nurse workforce decline
Authors: Moffat Polly
Published: November 2019

The UK's district nurse workforce is in decline, due to long-term under-investment in training, education and skills, posing a direct threat to patient safety
Implementation of duty of candour within neurosurgery: a national survey and framework for improved application in clinical practice
Authors: Basu S , Marcus HJ , Sayal P , Kitchen N , Ley R , Hutchinson PJ , Thorne L
Published: November 2019

Introduction

Statutory duty of candour was introduced in November 2014 for NHS bodies in England. Contained within the regulation were definitions regarding the threshold for what constitutes a notifiable patient safety incident. However, it can be difficult to determine when the process should be implemented. The aim of this survey was to evaluate the interpretation of these definitions by British neurosurgeons.

Materials and methods

All full (consultant) members of the Society of British Neurological Surgeons were electronically invited to participate in an online survey. Surgeons were presented with 15 cases and asked to decide in the case of each one whether they would trigger the process of duty of candour. Cases were stratified according to their likelihood and severity.

Results

In all, 106/357 (29.7%) members participated in the survey. Responses varied widely, with almost no members triggering the process of duty of candour in cases where adverse events were common (greater than 10% likelihood) and required only outpatient follow-up (7/106; 6.6%), and almost all members doing so in cases where adverse events were rare (less than 0.1% likelihood) and resulted in death (102/106; 96.2%). However, there was clear equipoise in triggering the process of duty of candour in cases where adverse events were uncommon (0.1–10% likelihood) and resulted in moderate harm (38/106; 35.8%), severe harm (57/106; 53.8%) or death (49/106; 46.2%).

Conclusion

There is considerable nationwide variation in the interpretation of definitions regarding the threshold for duty of candour. To this end, we propose a framework for the improved application of duty of candour in clinical practice.
Quality of Life in Families of Young Children With Autism Spectrum Disorder
Authors: Mello Catherine , Rivard Mélina , Terroux Amélie , Mercier Céline
Published: November 2019

The present study investigated family quality of life (FQOL) as experienced by 493 mothers and fathers (295 families) of young children with autism spectrum disorder (ASD) prior to receiving early intervention services in the province of Québec. These families were most satisfied with their physical and material well-being and least satisfied with their family interactions. Children's level of functioning across various standardized and subjective measures were positively associated with parents' FQOL. In both parents, family characteristics associated with financial and personal resources were also linked to FQOL. The child's age and the number of children were associated with mothers' FQOL. Overall, these findings provide a portrait of ASD-related stressors and resources relevant to both parents during the early childhood period.
Unified Extracurricular Activities as a Pathway to Social Inclusion in High Schools
Authors: Siperstein Gary N. , McDowell Emily D. , Jacobs Holly E. , Stokes Jeffrey E. , Cahn Andrea L.
Published: November 2019

The present study examined how a multicomponent intervention embedded in a high school's extracurricular framework impacts students' acceptance of peers with intellectual disability (ID). Data were collected from eight high schools, three of which implemented the Special Olympics Unified Champion Schools (UCS) program involving inclusive sports, clubs, and schoolwide events, and five of which did not. A pretest-posttest survey design was used to measure students' attitudes, perceptions, and interactions (n = 1,230). Lagged dependent variable modeling revealed that UCS participation significantly predicted improved attitudes toward peers with ID and perceptions of school social inclusion, as well as increased social interactions with peers with ID. Unified extracurricular activities may be the next step forward in promoting an inclusive school culture.
Analisando a seleção de portfólio de projetos com a abordagem multicritério construtivista em uma universidade / Analyzing projects portfolio selection under constructivist multicriteria approach in a higher education institution
Authors: Barbosa Fernando Pires , Löbler Mauri Leodir , Tagliapietra Rafaela Dutra , Lehnhart Eliete Dos Reis
Published: November 2019

A seleção de portfólio de projetos vem sendo estudada em diferentes contextos e a partir de diferentes abordagens. Dentre as abordagens, verifica-se o uso de modelos multicritério de apoio à decisão (MCDA) e, dentre estes, a abordagem construtivista (MCDA-C), utilizada como estratégia para facilitar a compreensão do problema quando este diz respeito a situações complexas. Assim, neste artigo, o MCDA-C foi utilizado como ponto de partida para elaborar um mecanismo de apoio à tomada de decisão relacionada à seleção de projetos em uma instituição federal ensino superior (IFES), com base em focus group envolvendo, dentre outros, o reitor e seus assessores. Dentre os resultados está a identificação de aspectos gerais que podem vir a ser tratados de maneira diferentes no contexto da seleção do portfólio de projetos de uma organização. Por fim, destaca-se a complexidade e diversidade de assuntos relacionados à construção de um modelo com abrangência institucional no âmbito de uma instituição de ensino superior.
A Estratégia de Saúde da Família e o diálogo sobre a Intersetorialidade / The Family Health Strategy and the Intersetoriality Dialogue
Authors: Ventura Antonia Natâniele Gomes Feitosa , Alencar Rayane Moreira de , Araújo Isaac De Sousa , Pinheiro Woneska Rodrigues
Published: November 2019

Este estudo objetivou verificar o diálogo entre os profissionais da Equipes de Saúde da Família sobre a intersetorialidade. Trata-se de um estudo transversal de cunho qualitativo. A amostra do estudo foi composta por 19 profissionais das ESFs. A coleta de dados foi realizada através de uma entrevista, utilizando roteiro pré-elaborado. Os dados foram transcritos na integra e analisados a partir da técnica de análise do Discurso do Sujeito Coletivo (DSC). Estabeleceu-se 3 categorias a partir dos dados obtidos de Ideias Centrais: Percepção dos profissionais da ESF sobre intersetorialidade; os caminhos da ESF para promoção do trabalho intersetorial; e desafios enfrentados pela ESF para desenvolver as ações intersetoriais. Conclui-se que as concepções dos profissionais da ESF sobre a intersetorialidade não se distanciam dos conceitos adotados pelos literatura vigente. Porém, o diálogo assumido pelos profissionais sobre intersetorialidade apresenta fragilidades em relação a efetiva legitimidade do termo na prática assistencial a saúde.
A Utilização da Controladoria para o gerenciamento de pequena empresa do setor industrial têxtil de Sertaneja-PR / The use of the Controller in the Management of small business in the Textile Industry in Sertaneja - PR
Authors: Silva Amanda Alves da , Neves Eduardo Adriano , Vaz Jhessyca Fernanda , Camilotti João Vitor Miyao , Marcelino José Antonio
Published: November 2019

As pequenas empresas estão surgindo cada vez mais no mercado de trabalho, e isso ocorre por conta da crise que se estabeleceu nos últimos tempos. Sendo assim, por conta do desemprego e o baixo índice de contratação do mercado, o surgimento dos microempreendedores aumentou mais no Brasil, e isso acontece por causa da necessidade de adquirir uma renda adequada para garantir o cuidado de si e da família, e muitas vezes, também pode servir como uma renda extra. Entretanto para que a empresa alcance resultados eficazes é importante que os microempreendedores utilizem de mecanismos para cuidar do gerenciamento da instituição, dessa maneira, é necessário recorrer à controladoria, que se faz um importante recurso para auxiliar no alcance dos objetivos que a empresa almeja e garantir que a empresa se mantenha no mercado de trabalho e com condições de competir com as demais, além de acentuar o seu crescimento. O presente artigo busca elencar a importância de se desenvolver planejamentos, para evitar surpresas desagradáveis. O artigo também apresentará a importância da controladoria e como aplicá-la em uma empresa de pequeno porte.
Representações Sociais da Adoção Tardia: A Busca pelo filho ideal / Late Adoption Social Representations: The search for the ideal son
Authors: Baldessar Jerusa Colombo , Castro Amanda
Published: November 2019

A pesquisa teve por objetivo identificar as representações sociais dos participantes do Curso de Preparação para Pretendentes à Adoção da Comarca de Criciúma/SC do ano de 2018 acerca da adoção tardia e verificar se o referido curso promove mudanças nessas representações. Participaram da pesquisa 55 requerentes. Para a coleta de dados foram aplicados dois formulários idênticos, sendo um no primeiro e um no último encontro do curso, utilizou-se o teste de substituição. A análise dos resultados foi feita com o auxílio do software Iramuteq. Os dados quantitativos passaram por estatística descritiva. Os resultados demonstraram que os participantes chegam ao curso carregados de paradigmas relacionados a adoção tardia, que se referem à imponência do fator genético e das experiências passadas na personalidade do adotando. Após o curso, foi possível perceber mudança significativa nas crenças dos pretendentes diante da adoção tardia, que passaram a ver esta adoção como algo mais possível.
Depressão Infantil e Dificuldades de Aprendizagem / Child Depression and Learning Difficulties
Authors: Bordignon Laís , Gomes Karin Martins , Nunes Rafael Zaneripe de Souza , Zavadil Stephane Catharine , Amboni Graziela , Tomasi Cristiane Damiani , Bitencourt Lisiane Tuon Generoso , Ceretta Luciane Bisognin
Published: November 2019

A Depressão Infantil pode afetar o processo de aprendizagem das crianças. Sendo assim, o presente artigo visa avaliar a relação entre crianças com sintomas depressivos e dificuldades de aprendizagem. Para atingir os objetivos específicos da pesquisa, a aplicação do Inventário de Depressão Infantil (CDI) foi usada para verificar quais os principais sintomas apresentados pelas crianças. Entrevistamos também os professores das crianças que apresentaram sintomas depressivos para verificar se as mesmas apresentavam dificuldades de aprendizagem. A pesquisa foi qualitativa e quantitativa. A amostra foram as crianças do 2º e 3º ano do ensino fundamental, no total de 58 alunos, mais os professores titulares desses anos, sendo 4 ao total. Os instrumentos utilizados foram o CDI e entrevista semiestruturada. Análise dos resultados foi através do SPSS 20.0 e análise de conteúdo para a entrevista. Conclui-se que a depressão infantil manifesta-se de maneira bem diversificada, trazendo prejuízos a todas as crianças afetadas.
Reabilitação Oral com o uso de Prótese Total: Relato de Caso Clínico / Oral Rehabilitation Using Full Prosthesis: Case Report
Authors: Carmo Fernando Clécio Santos do , Rocha Bruno Bomfim , Carvalho Felipe Rocha , Cunha Miguel Arcanjo Porto da , Cunha Daniela Porto da
Published: November 2019

O edentulismo provoca modificações na vida do indivíduo, tais como alterações estéticas, funcionais e psicossociais. Portanto, torna-se imprescindível a necessidade de reabilitação oral para solucionar os danos gerados pela perda dentária. O presente estudo é um caso clínico de reabilitação oral com o uso de prótese total removível, que tem como objetivo averiguar os efeitos e demonstrar os benefícios desse recurso. A paciente estudada apresentou queixa de perdas dentárias, e após exames clínicos e avaliações foi confeccionada a prótese que melhor se adequava às suas necessidades. Os resultados obtidos foram analisados à luz da literatura e concluiu-se que a prótese total é uma excelente alternativa para melhorar a função mastigatória, aumentar a autoestima e a qualidade de vida.
A Inserção do Psicólogo na Atenção Básica: A Visão dos Profissionais de Saúde / The Psychologist's Insertion in Primary Care: The Health Professionals' View
Authors: Cezário Paula Frassinetti Oliveira , Cezário Pietra De Oliveira , Medeiros Renata Lívia Fonseca Moreira de , Oliveira Cabral Symara Abrantes Albuquerque de , Pinheiro Lívia Viviane Lins Pereira , Batista Juliana Pereira
Published: November 2019

A contextualização da saúde pública do Brasil perpassa por uma longa trajetória desde a sua criação, podendo ser evidenciado inúmeros fatos negativos, passando por uma medicina curativa, de modo que só tinha direito à saúde aquele que contribuísse. Até chegar nos dias atuais, em que todo e qualquer cidadão brasileiro tem direito a uma saúde de qualidade. O início do exercício da psicologia nos serviços brasileiros de Atenção Básica (AB) data da década de 80 com inúmeras críticas a uma prática individual; sendo excluído da equipe um pouco mais na frente, o que não impediu sua atuação nesse sistema. A pesquisa foi realizada nas UBS da zona urbana na cidade de Cajazeiras-PB, com o objetivo de identificar a importância do Psicólogo nesse espaço através de uma entrevista semiestruturada com um questionário sociodemográfico, aplicada junto à equipe de nível superior como Médicos, Enfermeiros e Odontólogos, numa população com vinte e dois profissionais. Para a análise dos dados foi utilizada a técnica de análise de conteúdo de Minayo. Os resultados mostraram que nesse espaço em específico, os profissionais não se sentem preparados para atender a população assistida que em muitos casos demandam por questões psicossomáticas, e desmistificando a saúde mental, evidenciando a grande importância de o Psicólogo ser parte integrante da equipe de profissionais de nível superior da UBS e não somente no NASF como ainda acontece.
Uma Análise da Motivação dos Indivíduos nas Organizações a partir das Necessidades Humanas / An Analysis of Motivation of Individuals in Organizations from Human Needs
Authors: Silveira Elton Paulino Da , Prata Gildo Batista , Nunes Ana Lúcia De Paula Ferreira
Published: November 2019

Este artigo teve como objetivo apresentar um estudo teórico da motivação, correlacionando as principais teorias motivacionais com a percepção das necessidades intrínsecas do ser humano. A análise foi realizada através de uma revisão bibliográfica, embasada em autores da área, que discorrem sobre o tema. A partir do entendimento da história evolutiva das relações humanas perpassando pelas primeiras teorias motivacionais possibilitou um diagnostico parcial de causa e efeito de forma ampla. Observou-se que a motivação é ferramenta essencial na conquista dos objetivos da organização. Pois, possibilita entender o funcionamento do ciclo motivacional, no intuito de melhorar as relações humanas e potencializar os resultados na eficiência do conjunto. Espera-se que este estudo possa contribuir para o crescimento desta área de investigação auxiliando os gestores, a definirem os pontos cruciais para maximizar o aproveitamento das capacidades dos colaboradores melhorando o aspecto motivacional, investindo em qualidade de vida no trabalho, mantendo um ambiente saudável.
Gestão de Estoque nas Pequenas Empresas: Um Estudo de caso no Mercadinho e Hortifruti XY / Small Business Stock Management: A Case Study in the Merchant and Hortifruti XY
Authors: Barbosa Eneias Santos , Caffé Filho Hesler Piedade
Published: November 2019

O presente trabalho trata-se de um estudo de caso inerente a gestão de estoque realizado em uma microempresa do setor varejista localizada em Juazeiro-BA; O Mercadinho e Hortifrúti XY. O objetivo foi estudar de que forma o mercadinho e hortifrúti XY faz seu controle de estoque. A partir de seus objetivos, o presente estudo caracterizou-se como uma pesquisa de natureza descritiva com abordagem qualitativa na coleta e análise dos dados mediante realização de entrevista baseada na aplicação de questionário previamente elaborado. Os resultados indicam que a empresa XY está ativa a pouco tempo no mercado; mas já consegue identificar seu público alvo e possui um mix de produtos que atendem à demanda e que faz com que o seu estoque possua alta rotatividade. Com relação ao planejamento de compras é determinado de acordo com o nível de vendas e também por sazonalidade; prezando sempre por fornecedores locais que atendam aos prazos de entrega. O método de controle de estoque utilizado é o Peps (o que entra primeiro sai primeiro); além de possuir sistema informatizado para gerenciar suas entradas e saídas. De modo geral, as estratégias adotadas quanto ao controle de estoque têm transmitido resultados para a empresa, estando o proprietário satisfeito até o momento, pois, apesar de ter pouco de tempo de fundada; possui um gerenciamento de estoque sólido.
Anatomia e considerações clínicas dos Terceiros Molares Inclusos: Uma Revisão de Literatura / Anatomy and clinical considerations of the included third molars: A Literature Review
Authors: Ribeiro Júnior Cleber Oliveira , Rocha Bruno Bomfim , Carmo Fernando Clécio Santos do , Ladeia Júnior Luciano Ferreira
Published: November 2019

A remoção cirúrgica dos terceiros molares inferiores é um dos procedimentos cirúrgicos mais realizados em odontologia. Não há evidências para apoiar a remoção profilática de terceiros molares inferiores; em contraste, no caso de condições patológicas relacionadas ao terceiro molar mandibular, a remoção pode ser considerada. As alterações patológicas podem ser sintomáticas ou assintomáticas. Sendo, portanto, o objetivo do presente trabalho apresentar a impacção dos terceiros molares como um problema de saúde caracterizando a importância desses conhecimentos para o Cirurgião-dentista. Será realizada uma revisão de literatura a partir da busca nos bancos de dados PubMed e LiLacs para identificar as publicações disponíveis no período de 2009 a 2019. As seguintes palavras-chave serão utilizadas na busca: “Terceiros Molares Inclusos” em português e em inglês. Serão excluídos, resumos e resumos expandidos, estudos experimentais não finalizados, artigos latino-americanos. Os artigos encontrados serão separados e adicionados no Mendeley para identificação de duplicatas, após a exclusão das duplicatas serão lidos os títulos para a primeira etapa da seleção dos artigos, em seguida a leitura dos resumos que terá caráter de exclusão ou permanência do manuscrito e por fim a leitura do artigo na íntegra para composição da revisão da literatura.
Acolhimento com classificação de riscos em um Centro de Atenção Psicossocial / Reception with risk classification in a Psychosocial Care Center
Authors: Greco Patrícia Bitencourt Toscani , Silva Aline Soares da , Palmeiro Bibiana Kozorosky , Bernardi Camila Milene Soares , Rodrigues Sandra Ost , Barichello Fernanda Belle
Published: November 2019

O objetivo geral foi implantar o Acolhimento com Classificação de Riscos em um Centro de Atenção Psicossocial, a fim de ampliar a resolutividade do serviço. Trata-se de um relato de experiência acerca da implantação de um instrumento para a realização do Acolhimento e Classificação de Risco em um Centro de Atenção Psicossocial. Ocorreu na região centro oeste do Rio Grande do Sul, no período de agosto à novembro de 2017. Primeiramente, elaborou-se de forma coletiva um instrumento para o Acolhimento e Classificação de Risco e posteriormente aconteceu a implementação da prática, o que viabilizou acolhimento com agenda aberta, bem como, auxiliou na reorganização do fluxo de atendimento do serviço. Possibilitou melhorar o fluxo dos atendimentos aos usuários, e, refletir sobre gestão compartilhada dos cuidados a saúde e sugerir o apoio matricial como estratégia para implantação do Acolhimento com Classificação de Risco em saúde mental na Atenção Primária à Saúde.
Vedolizumab quantitation using high-resolution accurate mass-mass spectrometry middle-up protein subunit: method validation
Authors: Cradic Kendall W. , Ladwig Paula M. , Rivard Ann L. , Katrangi Waddah , Wintgens Karl Florian , Willrich Maria A.V.
Published: November 2019

Background

While quantitation methods for small-molecule and tryptic peptide bottom-up mass spectrometry (MS) have been well defined, quantitation methods for top-down or middle-up MS approaches have not been as well defined. Therapeutic monoclonal antibodies (t-mAbs) are a group of proteins that can be used to both demonstrate the advantages of top-down or middle-up detection methods over classic tryptic peptide bottom-up along with the growing need for robust quantitation strategies/software for these top-down or middle-up methods. Bottom-up proteolytic digest methods for the t-mAbs tend to suffer from challenges such as limited peptide selection due to potential interference from the polyclonal immunoglobulin background, complicated workflows, and inadequate sensitivity and specificity without laborious purification steps, and therefore have prompted the search for new detection and quantitation methods. Time-of-flight along with Orbitrap MS have recently evolved from the research and/or pharmaceutical setting into the clinical laboratory. With their superior mass measurement accuracy, resolution and scanning speeds, these are ideal platforms for top-down or middle-up characterization and quantitation.

Methods

We demonstrate a validated, robust, middle-up protein subunit detection and quantitation method for the IgG1 t-mAb, vedolizumab (VEDO), which takes advantage of the high resolution of the Orbitrap MS detection and quantitation software to increase specificity.

Results

Validated performance characteristics met pre-defined acceptance criteria with simple workflows and rapid turnaround times: characteristics necessary for implementation into a high-volume clinical MS laboratory.

Conclusions

While the extraction method can easily be used with other IgG1 t-mAbs, the detection and quantitation method may become an option for measurement of other proteins.
Menger algebras of k-commutative n-place functions
Authors: Dudek Wieslaw A. , Trokhimenko Valentin S.
Published: November 2019

We prove that the set of all k-commutative n-place functions defined on a fixed set forms a Menger algebra, and characterize such algebras by their densely embedded ideals.
We also describe all automorphisms of such algebras.
On Bluetooth Phonebook Manager
Authors: Abdulhamid Mohanad
Published: November 2019

The paper generally seeks to demonstrate an in depth understanding of computer communication using Bluetooth. The working principle of this technology has to be fully understood and thus the software required to save the phone book to the computer needs to be developed and implemented and thus demonstrated on how it works. The paper clearly illustrates how reliable the Bluetooth phone book manager is in terms of creating a backup of one’s contacts. The software program is developed and then analysed in depth to understand the workability of the phone book manager which runs on any computer and is compatible with any phone. The hardware used is USB Bluetooth dongle, a cell phone and a computer.
Análisis sobre el uso de la red social Facebook en el proceso de enseñanza-aprendizaje por medio de la ciencia de datos
Authors: Salas Rueda Ricardo Adán , Salas Rueda Rodrigo David
Published: November 2019

Hoy en día, los avances tecnológicos están provocando el desarrollo de nuevas estrategias de enseñanza-aprendizaje. De hecho, las redes sociales están adquiriendo gran relevancia durante la planeación de las actividades escolares. En particular, esta investigación mixta analiza el uso de Facebook como medio de difusión, comunicación, aprendizaje, interacción y colaboración durante la realización de las prácticas de laboratorio en la asignatura “Desarrollo de aplicaciones para los negocios”. La minería de datos permite establecer los modelos predictivos sobre el impacto de Facebook durante el diseño de la interfaz web considerando las técnicas bayesiana y árbol de decisión (ciencia de datos). La muestra está compuesta por 69 estudiantes de la Licenciatura en Gestión de Negocios y Tecnologías de Información. Por medio del enfoque cuantitativo y cualitativo, este estudio analiza el empleo de esta red social en el proceso de enseñanza-aprendizaje relacionado con el diseño de la interfaz web, las instrucciones HTML, el lenguaje de programación PHP, la aplicación WampServer y la base de datos MYSQL. Asimismo, el método ANOVA evalúa el rendimiento académico de los grupos experimental y control por medio de la calificación en el proyecto práctico. Los resultados obtenidos permiten afirmar que Facebook representa una alternativa tecnológica para mejorar la organización e implementación de las experiencias educativas en el siglo XXI.
Usabilidad de los smartphones en la infancia: estudio de caso a través de la fotografía
Authors: María del Mar Rodríguez Rosell  , Irene Irene Melgarejo
Published: November 2019

Ver a niños de entre 3 y 6 años interaccionando con los smartphones forma parte de nuestro paisaje urbano más natural. Nos encontramos ante nativos digitales que hacen uso de diversas funcionalidades que poseen estos dispositivos, con el fin de acceder y consumir productos audiovisuales como videojuegos, fotografías, vídeos, etc. Son instrumentos diseñados bajo una estrategia de mercado, pensados para facilitar el acceso a juegos, vídeos y música en cualquier momento y lugar. Esto provoca la facilidad de acceso y uso de esta tecnología por parte de los pequeños, que, sin embargo, encuentran limitaciones en su uso, normalmente impuestas por los progenitores que son los que finalmente deben pautar los tiempos y los contenidos a los que se expondrán sus hijos. La toma de fotografía es una de las actividades más habituales realizada a través de un smartphone por los niños, además de jugar o ver documentos audiovisuales. La experiencia que planteamos convierte al pequeño en un sujeto activo de la propia investigación, ya que aparece en el centro del estudio como sujeto productor y no sólo como sujeto. Nos interesa saber cuál es la percepción que los niños de 5 años tienen del uso de los smartphones y, sobre todo, analizar cómo son en la práctica los productos fotográficos que son capaces de hacer. A través de una metodología caleidoscópica y del desarrollo de técnicas variadas abordamos esta realidad.
THE EFFECTS OF DRYING METHODS ON THE QUALITY OF TURKISH NOODLE WITH LEGUME FLOURS
Authors: LEVENT Hacer , YEŞİL Saliha
Published: November 2019

In this study, legume flours (lentil, faba bean,
chickpea and common bean) replaced wheat flour (30%, w/w) in Turkish noodle
formulation.  The effects of the addition
of legume flours to the formulation and the different drying conditions (room,
hot oven and microwave) on the physicochemical, cooking and sensory properties
of noodles were investigated. The use of legume flour in noodle formulation
increased the ash, protein, fat, Ca, Fe, Mg, Cu, total phenolic content and
antioxidant activity of noodle samples (P
<0.05). In addition to shortening the drying time, microwave drying revealed
higher total phenolic content and antioxidant activity values among other
drying techniques. Legume flours, excluding faba bean,
gave acceptable sensory analysis results in noodle samples. The results show
that legume flour is an important source for improving the nutritional
properties of noodles and microwave drying can be recommended to maintain the total
phenolic content and antioxidant activity of the noodles.
STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations
Authors: Furigo Isadora C , Teixeira Pryscila D S , Quaresma Paula G F , Mansano Naira S , Frazão Renata , Donato Jose
Published: November 2019

AgRP neurons are important players in the control of energy homeostasis and are responsive to several hormones. In addition, STAT5 signalling in the brain, which is activated by metabolic hormones and growth factors, modulates food intake, body fat and glucose homeostasis. Given that, and the absence of studies that describe STAT5 function in AgRP cells, the present study investigated the metabolic effects of Stat5a/b gene ablation in these neurons. We observed that STAT5 signalling in AgRP neurons regulates body fat in female mice. However, male and female STAT5-knockout mice did not exhibit altered food intake, energy expenditure or glucose homeostasis compared to control mice. The counter-regulatory response or glucoprivic hyperphagia induced by 2-deoxy-d-glucose treatment were also not affected by AgRP-specific STAT5 ablation. However, under 60% food restriction, AgRP STAT5-knockout mice had a blunted upregulation of hypothalamic Agrp mRNA expression and corticosterone serum levels compared to control mice, suggesting a possible role for STAT5 in AgRP neurons for neuroendocrine adaptations to food restriction. Interestingly, ad libitum fed knockout male mice had reduced Pomc and Ucp-1 mRNA expression compared to control group. Taken together, these results suggest that STAT5 signalling in AgRP neurons regulates body adiposity in female mice, as well as some neuroendocrine adaptations to food restriction.
Impact of Digitalization on Service Work in Knowledge-Intensive Business Services: An Empirical Study in Tax Consultancies
Authors: Görs Philipp K. , Hummert Henning , Traum Anne , Nerdinger Friedemann W.
Published: November 2019

Digitalization is a megatrend, but there is relatively little knowledge about its consequences for service work in general and specifically in knowledge-intensive business services (KIBS). We studied the impact of digitalization on psychological consequences for employees in tax consultancies as a special case of KIBS. We compare two tax consulting jobs with very different job demands, those of tax consultants (TCs) and assistant tax consultants (ATCs). The results show that the extent of digitalization at the workplace level for ATCs correlates significantly positively with their job satisfaction. For TCs, the same variable correlates positively with their work engagement. These positive effects of digitalization are mediated in the case of ATCs by the impact on important job characteristics. In the case of TCs, which already have very good working conditions, the impact is mediated by the positive effect on self-efficacy. Theoretical and practical consequences of these results are discussed.
Interventions for Occluded Central Venous Catheters: A Meta-analysis
Authors: da Costa Ana Cristina Carvalho , Vieira Nayara Narley Pires , Vasques Christiane Inocêncio , Ferreira Elaine Barros , Guerra Eliete Neves Silva , dos Reis Paula Elaine Diniz
Published: November 2019

CONTEXT:

Thrombotic occlusion is 1 of the most frequent complications in catheters implanted in children.

OBJECTIVE:

To identify the interventions used to treat thrombotic events in long-term central venous catheters in pediatric patients with cancer.

DATA SOURCES:

Electronic searches were performed in the Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Latin American and Caribbean Health Sciences Literature, LIVIVO, PubMed, Scopus, Web of Science, Google Scholar, OpenGrey, and ProQuest databases. There were no restrictions on language or publication period.

STUDY SELECTION:

This systematic review was performed in 2 phases and included clinical trials and observational studies on drugs used to treat thrombotic catheter events in pediatric patients with cancer. The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist, and the protocol was registered at PROSPERO (identifier CRD42018083555).

DATA EXTRACTION:

The authors evaluated the quality of included studies using the Methodological Index for Nonrandomized Studies and Grading of Recommendations Assessment, Development and Evaluation methods. The meta-analysis was performed by using Stata software.

RESULTS:

Ten studies were included. The drugs used to restore catheter function were alteplase, urokinase, and streptokinase. A meta-analysis of 6 studies revealed an overall restoration rate of 88% for alteplase.

LIMITATIONS:

Reference studies were excluded when it was not possible to reliably extract data that met the inclusion criteria of this review. Sampling issues (absence of randomization, blinding, or a control group) were the main methodologic concerns for the included articles.

CONCLUSIONS:

On the basis of the evidence obtained, thrombolysis is effective and potentially safe in this population.
Timing of Complementary Feeding Introduction and Adiposity Throughout Childhood
Authors: Gingras Véronique , Aris Izzuddin M. , Rifas-Shiman Sheryl L. , Switkowski Karen M. , Oken Emily , Hivert Marie-France
Published: November 2019

OBJECTIVES:

To examine associations of the timing of complementary feeding (CF) introduction with adiposity throughout childhood.

METHODS:

We studied 1013 children from Project Viva. Our exposure was CF introduction, categorized as <4 months (19%), 4 to <6 months (68%; reference group), and ≥6 months of age (14%). Our outcomes included adiposity measures in midchildhood (mean: 7.9 years; SD 0.8; n = 896) and early adolescence (mean: 13.2 years; SD 0.9; n = 850). We used linear regression models adjusted for potential confounders and ran separate models for infants who were breastfed at least partly for ≥4 months (categorized as breastfed; 69%) and infants who were never breastfed or stopped breastfeeding at <4 months (categorized as formula fed; 31%).

RESULTS:

CF initiated at <4 months was associated with higher adiposity in midchildhood in breastfed children; associations persisted into adolescence for waist circumference, truncal fat mass, and the sum of subscapular and triceps skinfolds (eg, waist circumference: confounder-adjusted β 2.97 [95% confidence interval (CI) 0.47 to 5.47] cm). The effect estimates were larger in formula-fed children, with more associations persisting into adolescence (eg, waist circumference: adjusted β 3.42 [95% CI 0.12 to 6.71] cm). CF initiated at ≥6 months was associated with a higher subscapular/triceps skinfold ratio in midchildhood and adolescence (adjusted β 0.13 [95% CI 0.02 to 0.25]) in formula-fed children.

CONCLUSIONS:

We found associations of early CF introduction with higher adiposity measurements in breastfed and formula-fed children and associations of late introduction of CF with higher adiposity in formula-fed children.
MASTERING OF INNOVATIVE METHODS AND TECHNOLOGIES WITHIN COMPLEX APPROACH WHEN TEACHING A FOREIGN LANGUAGE AT HIGHER EDUCATIONAL INSTITUTIONS OF NON-LINGUISTIC PROFILE
Authors: Davydova N.V. , Dekusar G.G.
Published: November 2019

The article defines the concepts of "innovation" and "innovative teaching methods", provides a generalized characteristic of innovative methods and technologies of teaching a foreign language at a higher education institution of the non-linguistic profile. The emphasis is given on the necessity of implementing an integrated approach when applying the innovative teaching methods. The efficiency of using the newest technologies of teaching a foreign language in the learning process has been proved. The features of modern teaching methods of foreign languages ​​are defined, which offers a wide range of teaching concepts, methods and technologies - both traditional and innovative. It is suggested to give preference to one or another method depending on the purpose of studying, the student contingent, the duration and intensity of the training course. The authors of the article carried out a thorough analysis of contemporary research and publications regarding the problem of innovative approaches involved in teaching foreign languages ​​at a higher school and identified the relevance of research tasks that require significant changes in the educational system. The article points to the need for an optimal balance of traditions and innovations, a comprehensive combination of various technologies and methods of teaching a foreign language, which requires the use of an integrated approach. The purpose of the article is to justify the expediency of using an integrated approach in applying the innovative methods and technologies of teaching foreign languages ​​at higher education institutions of the non-formal profile.