bluuebunny/crossref_metadata_2025 huggingface dataset:
Millennial’s Residential Design Principle & Basic Model To Improve Work- from-Home Performance Through Mindfulness Practices
Authors: Purnaumbara Kartiansmara Lilih
Published: November 2023

Since the pandemic COVID-19 outbreak in 2020, it appears that the entire world has been forced to become acquainted with working from home as a new working concept. One of the dominant challenge in implementing work-from-home comes from decline of work performance caused by incapability to cognitively focus on several task at once. Millennial as a dominant productive age range in Indonesia are facing this continuously emerging problems, considering work-from-home working culture and flexible working are believed to be a future of work culture. When implementing work-from-home, millennials face the challenge to improve work performance, one of which is through mindfulness practices to help boost work performance. Through a literature review and design by research, this study seeks to identify a home and workspace design application model that accommodates mindfulness practices. Mindfulness practices are accommodated through flexible spatial planning, building materials with various texture, window openings in the workspace are strategically adjacent to green garden, green spaces with wide variety of colour, shape, and textures, and then the principle are applied in a residential models that fit the preferences for the millennial generation
The First Report on the Prevalence of Temperate Phages in a Dairy Samples
Authors: S Varalakshmi , Sanjeevi Thiyagarajan Chettiyar , Sambandam Ravikumar , Bhat Vishnu
Published: November 2023

Many dairy industries use their own starter cultures rather than Direct vat set culture because of their novelty and specific sensory characteristic it provides to their products. Starter culture rotation is not always possible, if the process involves the use of novel strains. The presence of bacteriophages in the environment leads to the quality instability of the product leads to the unexpected fermentation failure. In this context, a study of the prevalence of bacteriophages in the different sectors of dairy environment is carried out. The Screening of the phages has been undertaken with cheese and yoghurt cultures in the production and processing area. Three tests have been carried out to isolate the phages. Viz., turbidity test, double layer plaque assay, Spot test. Two natural temperate phages have been isolated from the cheese and yoghurt culture. Whereas the samples from the dairy processing environment is negative for phages. The temperate phages belong to the Siphoviridae family. Certain processing area where there is no involvement of starter culture e.g., paneer whey also showed the presence of phages in the whey, which indicates the air borne transmission of phages. Thus, the goal of this article is to make the quality assurance program associated with the production process of the fermented dairy products for the presence of phages in the dairy environment, with special emphasis on the preventive aspects related to this problem in the dairy fermentative industry.
System-Inherent Grid Synchronous Stability Boundary and Spontaneous Synchronization
Authors: Yuan Yu
Published: November 2023

Synchronization is a prerequisite for the stability of electrical energy, which is the cornerstone of a functioning society. Identifying whether generators are synchronized or not has been attracting immense research interest. Utilizing synchronized stability boundaries can strongly simplify stability discrimination. However, fundamental issues such as determining accurate stability boundaries remain challenging. In this study, an accurate synchronized stability boundary equation that is independent of the system and disturbances is presented, and it is applicable to an arbitrarily coupled grid. The special structure induced by spontaneous synchronization appears to be only near the stability boundary. The results of this study show that: the synchronous stability boundary is an intrinsic property of the system, independent of its structure and parameters. Synchronization on the network may be independent of the network. These conclusions will challenge the traditional perception of synchronization on networks, and the synchronization stability of the grid can be analyzed in a uniform way.
Epiphytic Subaerial Algae as Biological Indicators of Air Pollutants in Bangkok, Thailand
Authors: Saraphol Santi , Rindi Fabio , Sanevas Nuttha
Published: November 2023

In Bangkok, the capital city of Thailand, air pollution is a significant problem, and efforts are needed to define organisms that may be used as bioindicators of air pollution. Epiphytic subaerial algae, which grow on the surface of trees, may have a potential as bioindicators of urban air quality. Algae were collected from randomly selected tree trunks in five parks in Bangkok, and the air pollutants CO, NO2, O3, SO2, PM2.5, and PM10 were measured. Analysis of the subaerial algal communities was performed by metagenomics. Diversity indexes were determined for the algal taxa detected, which were separated into groups corresponding to different collection sites by cluster analysis. Relationships between taxa and air pollutants were analyzed by PCA and the Pearson correlation coefficient (r). The results showed a high diversity of epiphytic subaerial al-gae. We recorded 101 taxa belonging to the Cyanophyta (70 taxa), Chlorophyta (21 taxa), Char-ophyta (5 taxa), Bacillariophyta (3 taxa), and Eustigmatophyta (2 taxa). The most abundant taxon was Chroococcidiopsis sp. 1, for which up to 13,254 individuals/cm2 were recorded. The Shan-non–Weaver index ranged between 1.37 and 2.51, the Margalef index between 3.84 and 4.75, and the Pielou index between 0.30 and 0.54. The similarity index was between 8.00% and 64.82% ac-cording to the cluster analysis results for three groups. The PCA indicated that all air pollutants affected the diversity and abundance of the epiphytic subaerial algae. Cyanothece sp. 2 is consid-ered a potential bioindicator of air pollution. It was negatively related to O3 and positively related to NO2 and CO
Cancer Chemotherapy-Related Regimen Checks Performed by Pharmacists of General Hospitals Other Than Cancer Treatment Collaborative Base Hospitals: A Multicenter, Prospective Survey
Authors: Ueki Daisuke , Suzuki Shinya , Ohta Takahiro , Shinohara Akira , Ohashi Yasukata , Konuma Daisuke , Ryushima Yasuaki , Udagawa Ryoko , Motonaga Hironori , Ieoka Masahiro , Taji Akihiro , Kogure Yuuki , Hiraike Mikako , Uoi Miyuki , Ino Kasuhiko , Kawasaki Toshikatsu , Yamaguchi Masakazu
Published: November 2023

The aim of this prospective study was to examine the issues of these items to evaluate the possibility of their application to clinical practice. This prospective survey was performed on pharmacists of 14 hospitals. The number of confirmation items was 345 and 375 items in the control group and recommended item group, respectively. The mean time required for completing a regimen check (±standard deviation) was 4 minutes and 14 seconds (±1 minute and 50 seconds) and 6 minutes and 18 seconds (±1 minute and 7 seconds) in the control group and recommended item group, respectively. Among the recommended items, the mean number of items that pharmacists confirmed was 12.4 and 18.6 in the control and recommended items, respectively. The number of doubt inquiries was higher in the recommended item group than in the control group (41 vs. 27 cases). The number of doubt inquiries related to dosage, premedication, urinalysis, and a history of hepatitis B virus was higher in the recommended item group than in the control group. In the present study, we created 19 items that should be confirmed in regimen checks and examined the possibility of their application to clinical practice.
Recognition of Granulocyte-Macrophage Colony-Stimulating Factor by Specific S100 Proteins
Authors: Kazakov Alexey S. , Rastrygina Victoria A. , Vologzhannikova Alisa A. , Zemskova Marina Y. , Bobrova Lolita A. , Deryusheva Evgenia I. , Permyakova Maria E. , Sokolov Andrey S. , Litus Ekaterina A. , Shevelyova Marina P. , Uversky Vladimir N. , Permyakov Eugene A. , Permyakov Sergei E.
Published: November 2023

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic myelopoietic growth factor and proinflammatory cytokine, clinically used for multiple indications and serving as a promising target for treatment of many disorders, including cancer, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, COVID-19. We have previously shown that dimeric Ca2+-bound forms of S100A6 and S100P proteins, members of the multifunctional S100 protein family, are specific to GM-CSF. To probe selectivity of these interactions, the affinity of recombinant human GM-CSF to dimeric Ca2+-loaded forms of 18 recombinant human S100 proteins was studied by surface plasmon resonance spectroscopy. Of them, only S100A4 protein specifically binds to GM-CSF with equilibrium dissociation constant, Kd, values of 0.3-2 μM, as confirmed by intrinsic fluorescence and chemical crosslinking data. Calcium removal prevents S100A4 binding to GM-CSF, whereas monomerization of S100A4/A6/P proteins disrupts S100A4/A6 interaction with GM-CSF and induces a slight decrease in S100P affinity for GM-CSF. Structural modelling indicates the presence in the GM-CSF molecule of a conserved S100A4/A6/P-binding site, consisting of the residues from its termini, helices I and III, some of which are involved in the interaction with GM-CSF receptors. The predicted involvement of the ‘hinge’ region and F89 residue of S100P in GM-CSF recognition was confirmed by mutagenesis. Examination of S100A4/A6/P ability to affect GM-CSF signaling showed that S100A4/A6 inhibit GM-CSF/S100-induced suppression of viability of monocytic THP-1 cells. The ability of the S100 proteins to modulate GM-CSF activity is relevant to progression of various neoplasms and other diseases, according to bioinformatic analysis. The direct regulation of GM-CSF signaling by extracellular forms of the S100 proteins should be taken into account in the clinical use of GM-CSF and development of the therapeutic interventions targeting GM-CSF or its receptors.
Machine Learning-Based Assessment Indicates Patient-Reported Outcomes to Be Less Reliable than Clinical Parameters for Predicting 1-Year Survival in Cancer Patients.
Authors: Salvador Comino Maria Rosa , Youseff Paul , Heinzelmann Anna , Bernhardt Florian , Seifert Christin , Tewes Mitra
Published: November 2023

Machine learning (ML) techniques can help predict survival among cancer patients and might help with a timely integration in palliative care. We aim to explore the importance of subjective variables self-reported and collected via electronic patient reported outcome measure (ePROM) for survival prediction. A total of 256 advanced cancer patients met the eligible criteria. We analyzed objective variables collected from electronic health records, subjective variables collected via ePROM and all clinical variables combined. We used logistic regression (LR), decision trees, and random forests to predict 1-year mortality. Receiver operating characteristic (ROC) curve - area under the curve (AUC) and the ML models feature importance were analyzed. The performance of all variables for predictions (LR reaches 0.80 [ROC AUC] and 0.72 [F1 Score]) does not improve over the performance of only clinical non-patient reported outcome (non-PRO) variables (LR reaches 0.81 [ROC AUC] and 0.72 [F1 Score]). Our study indicates that patient-reported outcome (PRO) variables, which measure subjective burden, cannot be reliably used to predict survival. Further research in this area is needed to clarify the role of self-reported patient's burden and mortality prediction via ML.
A Forecasting Global Solar Radiation System Using Combined Supervised- and Unsupervised-learning Models
Authors: Wei Chih-Chiang , Yang Yen-Chen
Published: November 2023

One of the most important sources of energy is the sun. Taiwan is located at north 22-25° latitude. Due to its proximity to the equator, it experiences only a small angle of sunlight incidence. Its unique geographical location which can obtain sustainable and stable solar resources. This study takes research on the forecast of solar radiation to maximize the benefits of solar power generation, and develops methods that can predict the future solar radiation pattern to help reduce the costs of solar power generation. This study builds supervised machine learning models, known as deep neural network (DNN) and long short-term memory neural network (LSTM). The hybrid supervised and unsupervised model, namely cluster-based artificial neural network (k-means clustering and fuzzy C-means clustering-based models), was developed. After establishing these models, the study evaluated their prediction results. For different prediction periods, the study selected the best-performing model based on the results and proposed combining them to establish a real-time updated solar radiation forecast system capable of predicting the next 12 hours. The study area covered Kaohsiung, Hualien, and Penghu in Taiwan. Data from ground stations of the Central Weather Administration, collected between 1993 and 2021, as well as the solar angle parameters of each station, were used as input data for the model. The results of this study show that different models have their advantages and disadvantages in predicting different future times. Therefore, the hybrid prediction system can predict future solar radiation more accurately than a single model.
Theory of Relationships between Spaces to Obtain Numerical Knowledge
Authors: Cardoso Carlos Eduardo Ramos
Published: November 2023

The theory says that number interacts with spaces based on the meaning of mathematics, this way it is possible to obtain numerical knowledge. The theory shows the possibility of using spaces relating to each other to explain the reasons why two even numbers form a pair, two odd numbers form a pair, an even and an odd number form an odd number, three odd numbers form an odd number, three even numbers form an odd number. one even, one odd and two evens form an odd, two odd and one even form a pair.
The Educational Value of Artificial Intelligence in Higher Education: A Ten-Year Systematic Literature Review
Authors: Marengo Agostino , Pagano Alessandro , Soomro Kamal , Pange Jenny
Published: November 2023

With the emergence of artificial intelligence (AI), many aspects of our lives, from how we work to how we interact with each other and the world around us is showing dramatic changes. Education is one of the key areas that may be impacted by the rise of AI. Although a large number of studies have been conducted in recent years to shed light on how AI may influence various dimensions of education, a very little work has been carried out to consolidate and synthesis empirical studies on the application of AI in higher education.
The present study reviewed empirical studies published between 2013 and 2022 to 1) examine the characteristics of published research in the field, and 2) to present thorough insights on the promises and challenges of this dramatic technology in higher and professional education.
This review included 44 empirical studies published as peer-reviewed journal articles.
The results indicated that there is rapid increase in the publications focusing on AI in higher education in last a few years. However, a big proportion of these publications are technically theoretical and conceptual proposals for AI intervention. The areas of AI applications in higher education that are supported by evidence based research are presented. Imperative implications are also highlighted for future research and implementation of AI based interventions in higher education.
Treatment of Low Back Pain with Different Methods: A Systematic Review and Meta-Analysis
Authors: Dimitrijević Vanja , Rašković Bojan , Jevtić Nikola , Obradović Borislav , Grivas Theodoros B. , Viduka Dejan , Pjanić Samra , Chockalingam Nachiappan , Šćepanović Tijana , Drid Patrik
Published: November 2023

To systematically assess the effect size of different methods for patients with low back pain. PubMed, Cochrane Library, Web of Science, and Google Scholar. databases were searched in January 2023. This study has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. The key search terms were: “Low back pain”, “Back pain”, “SF-36”, “VAS”, “VASP”, “Roland-Morris”, “Oswestry Disability Index”, and “conservative treatment”. The risk of bias was determined for each randomized trial using the Cochrane Risk of Bias Tool, and the methodological index for non-randomized studies (MINORS). The outcomes included SF-36 Mental, SF-36 Physical, VAS, Roland-Morris, and Oswestry Disability Index. R 4.0.5 software was used, and standardized mean difference (SMD) and 95% confidence intervals (CI) were calculated for continuous outcomes, random model. Twenty-five studies were included. Depending on the outcome being measured, the effect size of different methods in treating low back pain varies from small to large as follows: SF-36 Mental (SMD = 0.39, p < 0.0001), SF-36 Physical (SMD = 0.55, p < 0.0001), VAS (SMD = -0.84, p < 0.0001), Roland-Morris (SMD = -0.45, p < 0.0001), and Oswestry Disability Index (SMD = -0.61, p < 0.0001). Our meta-analysis indicates the positive effects of applying different methods in the treatment of low back pain. PROSPERO registration number: CRD42022371282
Effects of Carotid Artery Stent (CAS) on Cognitive Function in Patients with Symptomatic Carotid Stenosis using MoCa Scale and Neuroimaging Test
Authors: Guirola José Andres , Ramon y Cajal Juan , Gimeno María José , Tejero Carlos , Piquero María Cruz , Yamamoto-Ramos Masao , De Gregorio Miguel Angel
Published: November 2023

Objectives: This prospective study aimed to assess the safety and efficacy of carotid angioplasty with stent (CAS) and its consequential impact on cognitive function, and to identify predisposing factors affecting cognitive response.
Materials and Methods: A total of 49 patients (median age 71.52, 80.8% male) who underwent CAS between January 2020 and August 2021 were analyzed. Cognitive evaluations utilized the MoCa scale, and neuroimaging was employed to detect neurological incidents, with comprehensive documentation of risk factors and comorbidities.
Results: Stent placement achieved a 93.8% success rate. Post-CAS neuroimaging disclosed multifocal ischemia in 8.16% of patients, microhemorrhages in 8.16%, and focal ischemia in 32.65%, with no clinically relevant deficits noted. A significant association (p=0.015) between severe stenosis and multifocal ischemic neurological events was observed. Cognitive improvements were evidenced in 53.8% of patients postoperatively, with kidney disease and cervical radiotherapy negatively correlated with cognitive response, while higher education level demonstrated a positive correlation.
Conclusions: CAS is established as a secure and efficient procedure, influencing cognitive function. The recognized predisposing factors contribute to enhanced patient selection and treatment strategy. Delving into the connection between these aspects and subsequent cognitive performance necessitates further investigation.
Proto–Neurons from Abiotic Polypeptides
Authors: --- Panagiotis Mougkogiannis , Adamatzky Andrew
Published: November 2023

Understanding the origins of life involves dealing with the unresolved question of how the first informational polymers and cell-like structures emerged from prebiotic chemistry. The formation of thermal proteinoids through the heating of mixtures of amino acids, leading to the spontaneous formation of protocells enclosed by membranes, presents a compelling model for the synthesis of polypeptides in an abiogenic context. Recent research has revealed the presence of electrical excitability and signal processing capacities in proteinoids, indicating the possibility of primitive cognitive functions and problem-solving capabilities. The present study provides a comprehensive examination of the features shown by heat proteinoids and their potential significance in the context of the artificial formation of polypeptides during the early stages of Earth’s development. Experiments showcasing the possibility for unconventional computing with proteinoids as well as modelling proteinoid assemblies into synthetic proto-brains are given. Proteinoids’ robust abiogenic production, biomimetic features, and computational capability shed light on potential phases in the evolution of polypeptides and primitive life from the primordial environment.
Low-Carbon Economic Dispatch of Virtual Power Plant considering Hydrogen Energy Storage and Tiered Carbon Trading in Multiple Scenarios
Authors: Xie Tuo , Wang Qi , Zhang Gang , Zhang Kaoshe , Li Hua
Published: November 2023

Under the "dual carbon" target in China, virtual power plants (VPPs) play an important role in improving grid security and promoting clean and low-carbon energy transformation. VPPs can integrate and control distributed resources to participate in the energy market and make full use of distributed resources. However, the intermittency and volatility of renewable energy and the "heat-driven" working mode of CHP units create contradictions that seriously affect the peak-shaving ability of VPPs and lead to high carbon emissions. To solve these problems, this paper aggregates CHP units, wind power, photovoltaics, carbon capture, hydrogen energy storage, and electric boilers into a new type of virtual power plant. The "hydrogen energy storage-electric boiler" joint decoupling CHP working mode is used to strengthen the coupling relationship between electric-thermal-hydrogen load. At the same time, a tiered carbon trading mechanism is considered, with the net profit of the VPP as the optimization objective, balancing economic and environmental considerations. A low-carbon economic dispatch model for VPPs is established, and a genetic algorithm is used for optimization. Three different scheduling strategies are set, and simulations are conducted in three different seasonal scenarios. The results show that the net profit in the cooling season increased by 50.4%, and carbon emissions decreased by 42.3%. In the transitional season, the net profit increased by 39.2%, and carbon emissions decreased by 44.9%. In the heating season, the net profit increased by 19.4%, and carbon emissions decreased by 43.4%. Overall, the proposed dispatch strategy can improve the new energy consumption capacity and total revenue of VPPs while achieving the goal of reducing carbon emissions.
Collision Tumors of the Colon and Peritoneum: Signet-Ring Carcinoma and Granular Cell Tumor
Authors: Lazureanu Dorela-Codruta , Anderco Denisa , Dema Sorin , Jurescu Aura , Cornea Remus , Vita Octavia , Tunescu Bogdan , Taban Sorina
Published: November 2023

Collision tumors, even uncommon, characterized by two distinctive (morphological, as well immunohistochemical) and spatially independent tumor components in the same location, are always puzzling for clinicians, pathologists and patients because they don’t fit in usual approaching schemes, neither diagnostic, nor therapeutic. Reviewing the specialized literature, until now, collision tumors have been reported in multiple locations such as the skin, esophagus, stomach, liver, kidney, bladder, adrenal gland or thyroid. We report a case of coexistence on the same site of a malignant tumor of ascending colon and a benign one emerging from peritoneal lining, thought initially by the surgeon to be right sided serosal carcinomatosis. But the histopatological examination reveals that those multiple serosal nodules were benign granular cell tumors collided with highly aggressive transparietal signet-ring colon carcinoma. These results put the patient's prognosis and therapeutic strategy in a different light than the clinical-imaging and intraoperative assessment.
How Close Is Existing C/C++ Code to a Safe Subset?
Authors: DeLozier Christian
Published: November 2023

Using a safe subset of C++ is a promising direction for increasing the safety of the programming language while maintaining its performance and productivity. In this paper, we examine how close existing C/C++ code is to conforming to a safe subset of C++. We examine the rules presented in existing safe C++ standards and safe C++ subsets. We analyze the code characteristics of 5.8 million code samples from the Exebench benchmark suite and 5 modern C++ applications using a static analysis tool. We find that raw pointers, unsafe casts, and unsafe library functions are used in both C++ code at large and modern C++ applications. In general, C++ code at large does not differ much from modern C++ code, and continued work will be required to transition from existing C/C++ code to a safe subset of C++.
Influence of an Ageing Heat Treatment on the Mechanical Characteristics of Iron-Aluminium Bronze with -Transformation: Modelling and Optimization
Authors: Maximov Jordan , Duncheva Galya , Anchev Angel , Dunchev Vladimir , Todorov Vladimir , Argirov Yaroslav
Published: November 2023

Aluminium bronzes possess a unique combination of high strength and wear and corrosion resistance in aggressive environments; thus, these alloys find wide application in marine, shipbuilding, aviation, railway, offshore platform applications and other fields. Iron-aluminium bronzes (IABs) are the cheapest and most widely used. When the aluminium content is above 9.4 wt%, IAB is biphasic (i.e. it undergoes -transformation) and can be subjected to all heat-treatment types depending on the desired operating behaviour of the bronze component. This article presents correlations (mathematical models) between the primary mechanical characteristics (yield limit, tensile strength, elongation, hardness and impact toughness) and the ageing temperature and time of quench at 920°C in water Cu-11Al-6Fe bronze, obtained using the centrifugal casting method. The microstructure evolution was evaluated depending on the ageing temperature and time changes. Overall, the research was conducted in three successive inter-related stages: a one-factor-at-a-time study, planned experiment, and optimisations. Four optimisation tasks, which have the greatest importance for practice, were formulated and solved. The defined multiobjective optimisation tasks were solved by searching for the Pareto-optimal solution approach. The decisions were made through a nondominated sorting genetic algorithm (NSGA-II) using QstatLab. The optimisation results were verified experimentally. Additional samples were made for this purpose, quenched at 920°C in water and subjected to subsequent ageing with the optimal values of the governing factors (ageing temperature and time) for the corresponding optimisation task. The comparison of the results for the mechanical characteristics with the theoretical optimisation results presents good agreement.
Recent and Future Advances in Water Electrolysis for Green Hydrogen Generation: Critical Analysis and Perspectives
Authors: Franco Alessandro , Giovannini Caterina
Published: November 2023

This paper explores the latest developments in electrolysis technology, a key player in the transition to sustainable energy systems. Electrolysis, despite currently contributing a small share to global hydrogen production, holds immense potential for producing green hydrogen. The study delves into the efficiency of electrolysis systems, emphasizing ongoing efforts to enhance energy conversion rates. It investigates the impact of high-temperature electrolysis on reducing electricity consumption, thus making the process more efficient. The paper discusses the various challenges in the research on water electrolysis and underscores the critical role electrolysis plays in integrating renewable energy sources. The study emphasizes the need for continuous advancements in electrolysis technology to bridge existing gaps, making a compelling case for its pivotal role in the green hydrogen revolution.
From Astrocyte Functions to Brain Dysfunctions: Brain “Stars” Take the Lead during Critical Periods of Early Postnatal Brain Development
Authors: Vivi Eugenia , Di Benedetto Barbara
Published: November 2023

Astrocytes regulate the shape and functions of the synaptic and vascular compartments through modulatory membrane-bound proteins or released factors. Their peculiar position further allows them to form a functional unit that “senses” the brain state and secrete factors in the bloodstream as a reflection of this state. Imbalanced astrocyte activity can therefore have a drastic negative impact on the formation of neuronal synaptic networks and lead to the development of severe brain pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology and molecular make-up in different affected brain regions in neurodevelopmental (ND) and neuropsychiatric (NP) disorders. The generation and differentiation/maturation of astrocytes (astrogenesis) occur during the critical period of early postnatal brain development. This is a time window of elevated astrocyte- and microglia-dependent synaptic phagocytosis (pruning), a process pivotal in refining neuronal networks. Therefore, any extrinsic and/or intrinsic cues altering this astrocyte-dependent synapse elimination during this critical period may result in altered synaptic remodeling and the onset of ND and NP disorders. Here, we collect recent advancements regarding astrogenesis and astrocyte-mediated regulation of neuronal network remodelling especially during early postnatal critical periods of brain development. We additionally propose alternative hypotheses to their putative involvement in the onset of ND and NP disorders. In light of the well-known differential prevalence of certain brain disorders between males and females, we also discuss sex-dependent effects on these neurodevelopmental processes.From a translational perspective, understanding age- and sex- dependent astrocyte-specific molecular and functional changes may help to identify biomarkers of distinct cellular (dys)functions in health and disease and may support the development of diagnostic tools or the selection of tailored treatment options for individual patients.
Homogeneity Assessment and Correction Methodology for the 1980-2022 Daily Temperature Series in Padua, Italy
Authors: Stefanini Claudio , Becherini Francesca , Della Valle Antonio , Rech Francesco , Zecchini Fabio , Camuffo Dario
Published: November 2023

Meteorological observations over the last four decades are of paramount importance to investigate the ongoing climate change. The assessment of the reliability of any climatic time series is thus mandatory to draw correct conclusions. This evaluation involves homogeneity tests to detect artificial discontinuities whose identification is facilitated by metadata availability. In this work, daily minimum and maximum temperature measurements collected in Padua, Italy, between 1980 and 2022, are examined. Hourly observations began in 1993 and since the aim is to study long term behavior of the temperature, the focus is on daily averages and extremes. Over this period, the weather station of Padua center underwent many changes, in location or instrument; therefore, some tests have been used to identify and remove the effects of these variations and obtain a homogeneous time series. The homogeneity tests applied must be able to identify change-points both in the middle and at the extremes of the series. Some well-known absolute tests have been applied to investigate shift in the mean value: Standard Normal Homogeneity test (SNH), Buishand U and range tests, Pettitt test, F-test, STARS. Some relative tests have been applied too, which are generally more reliable than absolute tests, because they consider the information from neighboring stations. As relative tests rely on the homogeneity and quality of the reference series, several nearby stations and two reanalysis datasets (ERA5 and MERIDA) have been considered, to enhance the picture of the local situation and provide more robust conclusions. The applied tests identify change-points in the years in which a change in instrument or location of the station have occurred, confirming that these changes have compromised the homogeneity of the series. The sub-series obtained splitting the observations in correspondence of these change-points have been homogenized with respect a selected period; corrections must be applied also to future measurements to extend the time series properly.
The Buildings (Dis)pathology: Analysis of Management Tools for Building Maintenance Services
Authors: Barbosa Maria Teresa Gomes , Galil Vinicius Martins , Santos White José dos , Carrasco Edgar , Rezende Marco Antonio , Carvalho Eliene , Alves Rejane Costa
Published: November 2023

Buildings are subject to intrinsic and extrinsic failures at all stages of the construction process, i.e., design to occupancy (i.e., use) as several failure types can affect them. There are three basic steps for researching building failures: listing, cataloging, and solving/deciding whether highlighting the least invasive and lowest cost intervention. Therefore, this research presents some methods used in construction for the intervention prioritization and seeks to illustrate the most suitable methodology for different settings failure x diagnosis x intervention. Therefore, the most traditional tools are shown: BASICO, SWIFT, FEMEA, AAF, and GUT matrix, where a critical assessment of the strengths and weaknesses is carried out. After that, a case study on maintenance services for the moisture on the building facades was performed. Finally, the GUT matrix and the FMEA method are the best results
Environmental Risk Factors Associated with Retinochoroiditis Caused by Toxoplasma gondii
Authors: Gomes Caroline Gil Ferreira , De Faria Jr Geraldo Magela , Pereira Gabriela Hamra , Cunha Filho Antônio Augusto de Andrade , Castiglioni Lilian , De Mattos Luiz Carlos , Previato Mariana , Siqueira Rubens Camargo , Cury Patrícia Maluf , Frederico Fábio Batista , Brandão Cinara Cássia
Published: November 2023

Objective: To evaluate which risk factors contribute directly or indirectly to Toxoplasma gondii infection in patients with ocular toxoplasmosis.
Methods: Between 2018-2020, a total of 306 patients were selected, and treated at the Retinology Outpatient Clinic of the Specialty Hospital of Sāo José do Rio Preto, in the state of São Paulo. After the fundoscopy test, the Enzyme Linked Fluorescent Assay (ELFA) was used to determine IgG and IgM class anti-Toxoplasma gondii antibodies.
Results: The results showed that individuals aged 60 years or older, and women who had a previous pregnancy, (p=0.000, OR= 8.137 and 95 % CI = 2.562 – 25.844), (p=0.016, OR= 7.395 and CI 95 % = 1,449 – 37,725) respectively, were 48.6 % more likely to develop ocular toxoplasmosis.
Conclusion: In this way, previous pregnancy is a risk factor for the reactivation of toxoplasma, as well as for the generation of retinochoroiditis in previously infected women.
Health Effects of Wildfires Reported in Emergency Medical Communication Centres: An Ecological Study in Gironde District, France, during the Summer of 2022
Authors: Eklöf Sofia , Lagarde Emmanuel , Tellier Eric , Russon Dylan , Pradeau Catherine , Laflamme Lucie , Gil-Jardine Cédric
Published: November 2023

Wildfires are a rising environmental threat which health impact remains poorly documented, in particular beyond the fire period. This ecological study investigates changes in health conditions before, during, and after two consecutive wildfires that occurred in France´s Gironde district in the summer 2022. Electronic records from the district´s emergency medical communication centre were used to identify calls with respiratory and cardiovascular diseases, and two specific subgroups of those, asthma (all ages and 0-5 years) and cardiac arrest, respectively. Compared to before the fires, respiratory disease cases were fewer during each fire (OR = 0.85, 95% CI: 0.79, 0.90 and OR = 0.62, 95% CI: 0.58, 0.67, respectively), cardiovascular disease cases, more common during the second fire, and asthma cases, higher following the fires (ORall ages= 1.85, 95% CI: 1.56, 2.21 and ORchildren= 3.52, 95% CI: 2.62, 4.80). Asthma cases also rose during the same calendar time in 2021, but to a lesser extent. In sum, except for asthma, emergency calls data in Gironde reveal few significant potentially smoke-related symptoms around fire periods, apart from post-fire asthma. Whether the effects are smoke- or season-related remains to be determined, preferably using additional data sources.
Desain Pelatihan Proyek Penguatan Profil Pelajar Pancasila Lintas Jenjang Pendidikan di Dinas Pendidikan Kabupaten Pangandaran, Jawa Barat
Authors: Setiawan Budi , Dewi Laksmi , Rusman Rusman , Arifin Zainal , Hernawan Asep Herry
Published: November 2023

Penelitian ini bertujuan untuk menemukan desain model pengembangan Profil Pelajar Pancasila yang diwujudkan melalui sistem pendidikan, sekaligus merupakan komitmen penyelenggara pendidikan dalam membangun sumber daya manusia Indonesia.  Profil pelajar, profil lulusan (graduate profile), potret lulusan (portrait of a graduate), atau luaran dari sistem pendidikan (student outcomes) adalah beberapa istilah yang memiliki makna serupa dengan Profil Pelajar Pancasila. Profil Pelajar Pancasila merupakan jawaban dari pertanyaan penting: “karakter serta kemampuan esensial apa yang perlu dipelajari dan dikembangkan secara terus-menerus oleh setiap individu warga negara Indonesia, sejak pendidikan anak usia dini hingga mereka menamatkan sekolah menengah atas?” Kemampuan esensial yang dimaksud adalah kemampuan yang tidak hanya melekat pada mata pelajaran, melainkan kemampuan yang bertahan lama (dibandingkan pengetahuan yang diingat), yang dibangun selama seseorang belajar di satuan pendidikan, bahkan hingga individu sudah bertahun-tahun menyelesaikan pendidikannya. Karakter dan kompetensi yang termuat dalam Profil Pelajar Pancasila diharapkan menjadi bekal yang cukup bagi setiap pelajar Indonesia untuk memaksimalkan potensi diri dan kecakapan hidupnya, serta hidup di tengah masyarakat dan turut berkontribusi dalam memajukan bangsa.
Estudo de variáveis de ensaio que influenciam os resultados de ensaios de resistividade elétrica volumétrica
Authors:   Departamento de engenharia Civil, UNIFUNCESI, Itabira, Brasil., Lage E. B. D. , Figueiredo E. P. ,   EECA, Universidade Federal de Goiás, Goiânia, Brasil, Paulino J. O. S. ,   DEE, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil., Chahud E. ,   DEMC, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil., Aguilar M. T. P. ,   DEMC, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Published: November 2023

O controle de qualidade do concreto se baseia, comumente, na avaliação da sua consistência no estado fresco e na sua resistência mecânica à compressão no estado endurecido. Em casos especiais, se controla a porosidade aparente, a resistência ao desgaste, a expansão devido à reação álcali- agregado, a resistência ao ataque dos íons cloretos, a resistência à carbonatação e a resistência ao ataque por sulfatos. Na maioria dos casos, tal controle ocorre por métodos destrutivos. No caso da resistência à entrada de agentes agressivos, íons cloretos, CO2 e sulfatos, por exemplo, existe a possibilidade de se avaliar a qualidade do concreto por meio do ensaio de resistividade elétrica. O ensaio de resistividade superficial é amplamente utilizado para estudo de estruturas in loco, enquanto o volumétrico se restringe a ensaios em corpos de prova para controle de qualidade do concreto. São poucos os dados sobre as variáveis que afetam estes ensaios, especialmente o método volumétrico. Neste contexto, e neste trabalho, se analisa algumas das variáveis do ensaio de resistividade elétrica volumétrica em um equipamento desenvolvido na Universidade Federal de Minas Gerais que utiliza corrente alternada. Os resultados indicam que o uso de lã de aço seca promove um contato adequado entre os eletrodos e a amostra. A imersão em água por no mínimo 2 horas e em câmara úmida por mais de 11 horas levam à saturação do corpo de prova e garantem a mesma condição de medição. Quando se utiliza corrente alternada, o uso de frequências na faixa de 10 Hz até 210 Hz parece não influenciar nos resultados de resistividade elétrica volumétrica.
Development of Religious Moderation Measurements
Authors: Ghufron M. Nur , Efferi Adri
Published: November 2023

This research with qualitative and quantitative approaches in order to develop measurements of religious moderation. There are stages that will be carried out, first determining the definition or concept of religious moderation, with a prototype methodology approach. Search, explain and describe individuals who have moderate nature in religion. Prototype methodology is used to obtain constructs of psychological variables, including cognitive, conative and psychomotor. Subsequent research compiles or develops measuring instruments for religious moderation. The first study was analyzed qualitatively, while the second study used quantitative analysis. Based on reliability tests with an alpha internal consistency approach, reliability was obtained of 0.90. Based on confirmatory analysis, it was found that chi-square 295.103 (DF = 164, p = 0.000), CMIN / DF = 1.799, GFI = 0.877, TLI = 0.887 and RMSEA = 0.062. Conclusion The criteria for acceptance of the model are met or have been as required. The proposed model design is the same as the empirical data or the model proposed fit. This means that religious moderation can be explained through tolerant behavior towards other people's religions and beliefs, having a national commitment, non-violence and being able to behave and behave accommodating with local culture.
The Sufism Healing as an Alternative Rehabilitation for Drug Addicts and Abusers
Authors: Laksana Andri Winjaya , Hartiwiningsih Hartiwiningsih , Purwadi Hari , Mashdurohatun Anis
Published: November 2023

This research aims to analyze and find the obligation of rehabilitation for drug addicts and abusers from the Islamic perspective and Sufism healing as an alternative rehabilitation for drug addicts. Sufism examines the spiritual aspects of Islam, while healing is the process of recovering from mental illness. This program plan becomes a hypothesis that is worth testing in prison for terrorism prisoners based on qualitative research methods with a phenomenological approach. Sufism healing has long been used to rehabilitate drug users in Islamic Boarding House (pesantren). The research approach in this research is a sociological juridical approach. The findings indicate that, according to an Islamic standpoint, rehabilitating those struggling with drug addiction is deemed obligatory due to the principle of al-Maqashid al-Syariah, which emphasizes the preservation of the mind (al-hifdzu al-aql) as an imperative need. The sufism healing, as a potential alternative approach to rehabilitating those struggling with drug addiction and substance misuse, centers on the objective of cultivating a greater connection with Allah the Almighty through the principles of takhalli, tahalli, and tajalli.
Gender Representation in Major Orthopaedic Surgery Meetings
Authors: Vivekanantha Prushoth , Dao Andre , Hiemstra Laurie , Shields Maegan , Chan Andrea , Wadey Veronica , Ferguson Peter , Shah Ajay
Published: November 2023

Background:

Orthopaedic surgery suffers from gender disparity, and annual conferences are visible opportunities to quantify gender representation within a field. Therefore, the purpose of this manuscript was to investigate the prevalence of female speakers and moderators, and male-only panel sessions, at 10 major Orthopaedic Surgery meetings.

Methods:

Conference programs and details of faculty moderating or presenting in 10 Orthopaedic Surgery annual meetings in 2021 were retrieved. Conferences were selected with the aim of size and diversity in subspecialty topics and included American Association of Hip and Knee Surgeons, American Association for Hand Surgery, American Academy of Orthopaedic Surgeons, American Orthopaedic Society for Sports Medicine, Canadian Orthopaedic Association (COA), European Federation of National Associations of Orthopaedics and Traumatology, North American Spine Society, Orthopaedic Research Society (ORS), Orthopaedic Trauma Association, and Pediatric Orthopaedic Society of North America (POSNA). Primary outcomes included percentage of female chairs and speakers and percentage of male-only panels, while secondary outcomes included number of publications, number of citations, and H-indexes of faculty. Further subgroup comparisons were performed between male-only panels and non–male-only panels and female members and male members.

Results:

Of 207 included sessions, 121 (58.5%) were male-only panels and 150 (12.6%) of 1,188 faculty members were women. Conferences organized by the COA, ORS, and POSNA had higher percentages of female representation, while spine surgery and adult hip/knee reconstruction sessions had more than 70% male-only panels and fewer than 10% female members. There were no significant differences between male members and female members regarding years of practice; however, male members were more likely to hold the title of professor (p < 0.001). Male members and female members stratified by quartiles of publications, citations, and H-indexes, moderated or participated in similar numbers of sessions, indicating an absence of selection bias.

Conclusions:

There is a high prevalence of male-only panels (58.5%) and an overall lack of female representation (12.6%) in 10 major Orthopaedic Surgery meetings. Male members and female members from these conferences were found to have similar qualifications academically. Specific strategies such as the elimination of male-only panels, selecting diverse conference organizers, and forming conference equity, diversity, and inclusion committees can help achieve cultural change.

Level of Evidence:

Level V.
The Сircular Understanding of Rationality and the Experimenter’s Regress
Authors:   Institute of Philosophy, Russian Academy of Sciences, Stoliarova Olga E.
Published: November 2023

The article deals with the problem of circular proof, which arises in the philo­sophical discussions about rationality, its ideals and standards. Trying to define what rationality is, we are forced to refer to its ideals and criteria, the rationality of which must be established in advance with the help of rational procedures. This situation is characterized as an epistemic circular dependence of the instru­ment and the result and is compared with the situation of experimenter’s regress. The experimenter’s regress is a circular reasoning in which it is possible to judge the correctness of the scientific results obtained only on the basis of the correct­ness of the procedure for obtaining them, and it is impossible to judge the cor­rectness of the procedure for obtaining them without reference to the obtained results. Thus, the proponents of the objectivity of the result and their opponents have no rational grounds for choosing one of the alternatives. The epistemo­logical problematization of the experimenter’s regress indirectly problematizes the theories of rationality, since science and the criteria of rational choice adopted in it act as standards of rationality in itself. It is shown that the epistemological justification of overcoming the experimenter’s regress is carried out by referring to “external factors” that are rationalized by the epistemologist. Although these external factors are declared “irrational,” they are rationalized in the epistemolo­gist’s “laboratory,” add to the baggage of the grounds of rational consent, and en­rich the notion of rationality. This allows us to qualify the circle described by ra­tionality in defining itself as virtuous.