bluuebunny/crossref_metadata_2025 huggingface dataset:
Fostering Post-Fire Research Towards a More Balanced Wildfire Science Agenda to Navigate Global Environmental Change
Authors: Gonçalves João , Portela Ana Paula , Regos Adrián , Sil Ângelo , Marcos Bruno , Alonso Joaquim , Honrado João
Published: January 2025

As wildfires become more frequent and severe in the face of global environmental change, it becomes crucial not only to assess, prevent, and suppress them but also to manage the aftermath effectively. Given the temporal interconnections between these issues, we explored the concept of the “wildfire science loop”—a framework categorizing wildfire research into three stages: “before”, “during”, and “after” wildfires. Based on this partition, we performed a systematic review by linking particular topics and keywords to each stage, aiming to describe each one and quantify the volume of published research. The results from our review identified a substantial imbalance in the wildfire research landscape, with the post-fire stage being markedly underrepresented. Research focusing on the “after” stage is 1.5 times (or 46%) less prevalent than that on the “before” stage and 1.8 (or 77%) less than that on the “during” stage. This discrepancy is likely driven by a historical emphasis on prevention and suppression due to immediate societal needs. Aiming to address and overcome this imbalance, we present our perspectives regarding a strategic agenda to enhance our understanding of post-fire processes and outcomes, emphasizing the socioecological impacts of wildfires and the management of post-fire recovery in a multi-level and transdisciplinary approach. These proposals advocate integrating knowledge-driven research on burn severity and ecosystem mitigation/recovery with practical, application-driven management strategies and strategic policy development. This framework also supports a comprehensive agenda that spans short-term emergency responses to long-term adaptive management, ensuring that post-fire landscapes are better understood, managed, and restored. We emphasize the critical importance of the “after-fire” stage in breaking negative planning cycles, enhancing management practices, and implementing nature-based solutions with a vision of “building back better”. Strengthening a comprehensive and balanced research agenda focused on the “after-fire” stage will also enhance our ability to close the loop of socioecological processes involved in adaptive wildfire management and improve the alignment with international agendas such as the UN’s Decade on Ecosystem Restoration and the EU’s Nature Restoration Law. By addressing this research imbalance, we can significantly improve our ability to restore ecosystems, enhance post-fire resilience, and develop adaptive wildfire management strategies that are better suited to the challenges of a rapidly changing world.
Fire Safety Assessment of Building-Integrated Photovoltaics (BIPVs)
Authors: Fang Ping , Zhao Lihong , Song Guangheng , Dong Jiaqi , Zhao Jinlong , Wang Zhenhua
Published: January 2025

Building-Integrated Photovoltaic (BIPV) systems, which seamlessly integrate solar photovoltaic components into building structures, have garnered widespread attention for their aesthetic appeal and energy efficiency. However, the promotion of BIPV systems has also raised new fire safety concerns. This paper reviews recent fire incident cases and conducts risk identification for factors such as building and environmental risks, photovoltaic systems, electrical equipment, and safety protection. A fire risk assessment is performed using the Analytic Hierarchy Process (AHP) to evaluate the overall fire safety of BIPV systems. Based on the assessment, corresponding safety design strategies are proposed to ensure the safety of buildings and occupants. The research results indicate that BIPV systems pose certain fire hazards, and that proper design and regulation are crucial to mitigate these risks.
In Situ Ecological Floating Bed Remediation Alters Internal Trophic Structure: A Case Study of Meiliang Bay, Lake Taihu
Authors: Cao Bingyin , Ren Long , Wang Yuan , Bing Xuwen , Kuang Zhen , Xu Dongpo
Published: January 2025

Ecological floating beds are effective in mitigating lake eutrophication. To examine the effects of their in situ remediation processes on the food sources and trophic structures of consumers, particularly fish, this study used stable isotope techniques to compare cage enclosures, net enclosures, and natural lake area in Meiliang Bay, Lake Taihu. The results revealed that among basic carbon sources, only the δ13C values of phytoplankton and POM differed significantly, while most consumers showed no significant differences in carbon and nitrogen stable isotope characteristics across the three remediation areas. In cage enclosures, the food chain transitioned from being grazing-based, dominated by phytoplankton, to detritus-based, primarily relying on SOM. In contrast, net enclosures enhanced the utilization of phytoplankton. The trophic levels of most consumers in cage enclosures were significantly lower than those in net enclosures and the natural lake area. Trophic niche indices indicated that cage enclosures exhibited the highest trophic diversity and the lowest trophic redundancy. The in situ remediation using ecological floating beds altered the food resource conditions within the remediation areas due to differences in the degree of enclosure provided by the floating beds and interception facilities. These changes have consequently reshaped the internal trophic structure through trophic cascade effects.
Mitigating Vibrio-Induced Skin Ulceration in Sea Cucumbers Using Probiotic Strains
Authors: Zhang Wan , Che Jian , Sun Xiaowen , Murtaza Bilal , Zhang Chenghao , Li Xiaoyu , Wang Lili , Xu Yongping
Published: January 2025

Sea cucumbers are valuable in aquaculture, but their cultivation faces challenges from diseases such as skin ulceration syndrome caused by Vibrio alginolyticus (VA). This study aimed to isolate and identify probiotics capable of combating VA and improving sea cucumber’s growth performance. Pathogenic VA was identified, through 16S rDNA sequencing, confirming its high genetic similarity (>99%) to Vibrio alginolyticus. Two Bacillus strains, Bacillus licheniformis YB-1, and Bacillus megaterium YB-2, were isolated as potential probiotics, with identification supported by 16S rDNA phylogenetic analysis and deposition in microbial culture collections. They demonstrated strong antibacterial activity against VA in vitro without exhibiting antagonism when combined. Probiotic tolerance to environmental stressors was observed, while feeding trials revealed significant growth improvements in sea cucumbers, with the highest specific growth rates observed at 1 × 106 CFU/mL for both strains. Immersion challenge tests showed that sea cucumbers treated with probiotics exhibited reduced symptoms of rotten skin syndrome and higher survival rates. The optimal combination of YB-1 and YB-2, with viable bacteria concentrations of 5 × 107 CFU/mL each, achieved a 55% survival rate after a VA challenge, demonstrating their synergistic efficacy. These findings suggest that YB-1 and YB-2 offer promising probiotic solutions for enhancing sea cucumber health and resistance to VA infections in aquaculture.
Instability of a Film Falling Down a Bounded Plate and Its Application to Structured Packing
Authors: Croce Giulio , Suzzi Nicola
Published: January 2025

The instability of a film falling down a vertical plate with lateral walls, which is the base configuration describing the structured packing geometry, is numerically investigated via the lubrication theory. The solid substrate wettability is imposed through the disjoining pressure, while the assumption of a tiny, precursor film thickness allows for modelling a moving contact line. Contact angles up to 60∘, which falls in the range of structured packing applications, are investigated, thanks to the full implementation of the capillary pressure instead of the small slope approximation. Parametric computations are run for a film falling down a vertical plate bounded by lateral walls, changing the plate width and the flow characteristics. An in-house, finite volume method (FVM) code, previously developed in FORTRAN language and validated in the case of film instability and rivulet flow, is used. The number of observed rivulets, triggered by the instability induced by the lateral walls, is traced for each computation. The numerical results suggest that rivulets with a given wavelength, equal to the one provided by the linear stability analysis, are generated, but only those characterized by a wavelength greater than a minimum threshold, which depends on the substrate wettability, induce partial dewetting of the domain. This allowed for the development of a simplified, statistically based model to predict the effective interface area and the rivulet holdup (required to estimate the mass transfer rate in absorption/distillation applications). Compared to the literature models of the structured packing hydrodynamics, which usually assume a continuous wetting layer, the influence of the flow pattern (continuous film or ensemble of rivulets) on the liquid holdup and on the interfacial area is introduced. The predicted flow regime is successfully verified with evidence from the literature, involving a flow down a corrugated sheet.
Characteristics of Food Printing Inks and Their Impact on Selected Product Properties
Authors: Domżalska Zuzanna , Jakubczyk Ewa
Published: January 2025

Three-dimensional printing, or additive manufacturing, produces three-dimensional objects using a digital model. Its utilisation has been observed across various industries, including the food industry. Technology offers a wide range of possibilities in this field, including creating innovative products with unique compositions, shapes, and textures. A significant challenge in 3D printing is the development of the optimal ink composition. These inks must possess the appropriate rheology and texture for printing and meet nutritional and sensory requirements. The rheological properties of inks play a pivotal role in the printing process, influencing the formation of stable structures. This article comprehensively characterises food inks, distinguishing two primary categories and their respective subgroups. The first category encompasses non-natively extrudable inks, including plant-based inks derived from fruits and vegetables and meat-based inks. The second category comprises natively extrudable inks, encompassing dairy-based, hydrogel-based, and confectionary-based inks. The product properties of rheology, texture, fidelity, and printing stability are then discussed. Finally, the innovative use of food inks is shown.
Extraction and Characterization of Antioxidants and Cellulose from Green Walnut Husks
Authors: Savić Ivan M. , Savić Gajić Ivana M.
Published: January 2025

The ultrasound-assisted extraction process with microwave pretreatment was modeled and optimized to maximize the yield of antioxidants from green walnut husks using a response surface methodology with Box–Behnken design. In this design, the ultrasound-assisted extraction time (10–40 min), ultrasound-assisted extraction temperature (40–60 °C), and microwave pretreatment time (20–60 s) were selected as the factors, while the total antioxidant content was defined as the response. The solvent of choice for extracting antioxidants was 50% (v/v) ethanol. After optimization using the desirability function, an ultrasound-assisted extraction time of 23 min, ultrasound-assisted extraction temperature of 60 °C, and microwave pretreatment time of 60 s were proposed as the optimal conditions and their validity was verified. Under these conditions, the experimentally determined total antioxidant content was 3.69 g of gallic acid equivalent per 100 g of dry matter. In addition to phenolics, UHPLC–ESI–MS/MS analysis indicated the presence of lipids, quinones, terpenoids, and organic acids in the extract. After the antioxidant extraction, the solid residue was further processed to isolate cellulose in line with the concept of sustainable manufacturing. The structural characterization and hydration properties of cellulose were analyzed to identify its key features and assess its potential for value-added applications. The results demonstrate that green walnut husks are a valuable and cost-effective agro-industrial byproduct for extracting antioxidants and isolating cellulose. This aligns with the principles of a circular economy and the sustainable production of natural compounds.
The Role of Food Security in Mediterranean Diet Adherence Among Adolescents: Findings from the EHDLA Study
Authors: Aquino-Blanco Andrea , Jiménez-López Estela , Victoria-Montesinos Desirée , Gutiérrez-Espinoza Héctor , Olivares-Arancibia Jorge , Yañéz-Sepúlveda Rodrigo , Martín-Calvo Nerea , López-Gil José Francisco
Published: January 2025

Food insecurity is a growing public health concern, particularly among vulnerable groups such as adolescents, and it has been linked to poor nutritional outcomes and increased risk of chronic diseases. The Mediterranean diet (MedDiet) is recognized for its numerous health benefits, yet few studies have explored the association between food insecurity and adherence to the MedDiet among adolescents, especially in Mediterranean regions. Objective: This study aimed to investigate the association between food insecurity and adherence to the MedDiet in a sample of adolescents from Spain. Methods: Data were acquired from 2021–2022 school years from adolescents aged 12–17 years enrolled in different secondary schools in Valle de Ricote, Region of Murcia, Spain. Food security was assessed via the Spanish Child Food Security Survey Module (CFSSM-S), and adherence to the MedDiet was assessed via the Mediterranean Diet Quality Index for Children and Adolescents (KIDMED). A total of 836 participants were involved, and statistical analyses were conducted via linear regression models adjusted for lifestyle, anthropometric, and sociodemographic covariates. Results: After adjusting for potential confounders, the mean KIDMED score was 7.0 (95% confidence interval [CI] 6.7 to 7.2) in the food-security group, 6.8 (95% CI 6.3 to 7.3) in the low-security group, and 5.9 (95% CI 4.9 to 6.9) in the very-low-security group. Notable differences were observed between participants with food security and their counterparts with very low food security (p = 0.040). Compared with those with food security (57.2%, 95% CI 51.5% to 62.8%), a significantly greater likelihood of having nonoptimal adherence to the MedDiet was identified in adolescents with low food security (61.6%, 95% CI 50.4% to 71.8%) and in those with very low food security (77.4%, 95% CI 54.5% to 90.7%). We identified a significant difference only between adolescents with food security and their peers with very low food security (p = 0.036). Conclusions: The findings suggest that very low food security negatively impacts MedDiet adherence in adolescents. Compared with their food-secure peers, adolescents with very low food security showed significantly poorer diet quality. These results highlight the importance of addressing food insecurity through low-cost, high-nutrition programs aimed at improving healthy eating habits, particularly for children and adolescents living in low-food-security households.
Development of a Theoretical Model for the Price Formation of Agri-Food Products in the Food Supply Chain: A Slovenian Case Study
Authors: Prišenk Jernej , Zidar Nejc , Turk Jernej
Published: January 2025

The main objective of the research was to develop a theoretical model for price construction in the agri-food sector, which should enable better transparency and efficiency of pricing policies in the food supply chain. The central part of the article focuses on the data set, in which the data sources and the economic analysis methodology are presented in detail. Based on this analysis, a theoretical model for pricing was developed, which is presented in more detail in a separate chapter. The model focuses on prices in three sectors (primary production, food processing industry and distribution/retail) of different food and agri-food chains and offers concrete solutions to improve pricing in these chains. The final chapter contains guidelines and recommendations for the practical application of the model with the aim of improving the transparency and effectiveness of pricing policy in the agri-food sector. The overall report represents an important contribution to understanding the behaviour and responsiveness of agri-food systems to specific cost changes and provides useful guidance for policy makers and stakeholders in the agri-food sector.
Food-Grade Pickering Emulsions Stabilized by Ultrasound-Treated Foxtail Millet Prolamin: Characterization and In Vitro Release Behavior of Curcumin
Authors: Guo Yu , Luo Yuewei , Ren Zhiyuan , Zhang Xinpeng , Duan Huiling , Liu Zhizong , Wang Xiaowen
Published: January 2025

To date, extensive studies have focused on developing proteins as stabilizers to fabricate food-grade emulsions for encapsulating bioactive compounds aimed at targeted delivery. This paper aimed to develop a novel stabilizer using foxtail millet prolamin (FMP) to fabricate medium internal-phase Pickering emulsions (MIPEs) and investigate the stability and in vitro release behavior of curcumin (Cur) encapsulated within the MIPEs. Ultrasound treatment modified the secondary and tertiary structures of FMP, along with its particle size, zeta potential, and wettability, enhancing its functionality as a stabilizer for MIPEs. The MIPEs stabilized by 65% ultrasound-treated FMP (FMP-U) exhibited better rheological properties and stability, significantly improving the storage stability and antioxidant activity of Cur. In vitro digestion results demonstrated that the MIPEs delayed the release of Cur, achieving a final release rate of 84.0 ± 1.47% after 4 h of gastrointestinal digestion and the DPPH radical scavenging activity (RSA) of 39.9 ± 1.31%, which was notably higher than the RSA of free Cur in oil at only 5.8 ± 1.37%. Moreover, MIPEs with Cur increased the bioaccessibility of Cur. This study provides new insights into a novel delivery system designed with FMP-U for encapsulating hydrophobic compounds, thereby enhancing their stability, sustained release, and bioaccessibility.
Evaluation of the Effect of Improvers: Psyllium and Xanthan Gum in Bread Loaf with Partial Replacement of Quinoa Flour
Authors: Quinte Laidy , Valderrama Ingrid , Best Ivan
Published: January 2025

Wheat flour (WF) was replaced with quinoa flour (QF) at a 20% level in combination with improvers such as psyllium (PSY) and xanthan gum (XG). The flour quality, dough rheology, baking quality, and sensory evaluation of the bread loaves were analyzed, considering the addition of improvers as follows: PSY 0.5%, XG 0.5%, and PSY 0.25% + XG 0.25%. The best treatment to produce bread loaves was with the application of PSY 0.25% + XG 0.25%, where it had an optimal acceptability and no significant texture difference (p ≥ 0.05) compared with the control, with manageable dough, ideal viscosity, intermediate width/height ratio, and moderate baking stability, reflected in reduced baking losses. The techno-functional and nutritional properties of QF offer a viable alternative to WF.
COI Metabarcoding as a Novel Approach for Assessing the Honey Bee Source of European Honey
Authors: Honrado Mónica , Quaresma Andreia , Henriques Dora , Pinto M. Alice , Amaral Joana S.
Published: January 2025

Honey is a widely consumed food product frequently subjected to adulteration, with the mislabeling of its botanical or geographical origin being one of the most common practices. Determining the entomological origin of honey is particularly challenging but of high relevance for ensuring its authenticity, especially for products with protected designation of origin (PDO) labels. This study presents a novel DNA metabarcoding approach targeting a highly informative 406 bp fragment of the cytochrome c oxidase I (COI) gene to differentiate among the three major mitochondrial lineages (A, M, and C) of honey bees (Apis mellifera L.) native to Europe. The target region was selected based on the calculated fixation index (FST), which is frequently used in Population Genetics as a measure of differentiation between populations. The approach was validated with 11 honey samples of known entomological origin and applied to 44 commercial honeys from 13 countries. The approach demonstrated high sensitivity, accurately identifying the entomological origin of honey, including samples produced by honey bees of varying ancestries, which could not be resolved by previous methods based on real-time PCR coupled with high-resolution melting (PCR-HRM) analysis. The results demonstrate the effectiveness of COI metabarcoding in verifying honey authenticity and highlight the predominance of C-lineage honey bees in the production of commercial honeys from northwestern Europe. This finding suggests a limited presence of the native M-lineage ancestry, underscoring the need for conservation efforts.
Systematic Review: Fragile X Syndrome Across the Lifespan with a Focus on Genetics, Neurodevelopmental, Behavioral and Psychiatric Associations
Authors: Genovese Ann C. , Butler Merlin G.
Published: January 2025

Background/Objectives: Fragile X syndrome (FXS) is one of the most common genetic causes of intellectual developmental disability and autism spectrum disorder (ASD), second only to Down’s syndrome and associated with a broad range of neurodevelopmental, behavioral, and psychiatric challenges. FXS may be present in infants or young children with characteristic dysmorphic features, developmental delays, and behavioral challenges. The diagnosis of FXS is confirmed by the molecular genetic testing of the FMR1 gene encoding fragile X messenger RNA-binding protein (FMRP), involved in regulating the translation of multiple mRNAs which play a key role in neuronal development and synaptic plasticity. Understanding the genetic cause, pathophysiology, and natural history of FXS is crucial for identifying commonly associated comorbidities, instituting effective therapeutic interventions, and improving long-term outcomes. Methods: This systematic review employed a comprehensive literature search using multiple electronic databases including PubMed, Web of Science, and Scopus with keywords related to fragile X syndrome, lifespan, genetics, neurodevelopmental, behavioral, and psychiatric disorders. Results: FXS is associated with an increased risk for specific neurodevelopmental, or psychiatric disorders. Symptoms and challenges associated with FXS vary based on multiple factors, including genetic differences, age, sex, comorbid conditions, various environmental influences, the availability of support, and opportunities for therapeutic interventions. Knowledge of these associations helps guide caregivers and clinicians in identifying potentially treatable conditions that can help to improve the lives of affected patients and their families. Conclusions: The focus of this article is to explore and describe the genetic underpinnings of FXS, identify associated developmental, behavioral, and psychiatric conditions over the lifespan, and provide a review of clinical features, therapeutic interventions including investigational treatments, and current research updates.
NETest and Gastro-Entero-Pancreatic Neuroendocrine Tumors: Still Far from Routine Clinical Application? A Systematic Review
Authors: Rossi Roberta Elisa , La Salvia Anna
Published: January 2025

Background: Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are the most prevalent subgroup among NETs and include heterogeneous tumors characterized by different clinical behavior and prognosis. The NETest is a tool based on real-time PCR combined with deep learning strategies to specifically identify tumors with a neuroendocrine genotype. Despite the promising results achieved regarding its utility in the field of GEP-NETs, the NETest has not yet entered into routine clinical practice. Methods: We performed a systematic review aimed at summarizing available evidence on the application of the NETest in both the diagnosis and the prognostic stratification of GEP-NETs. Results: We identified five studies evaluating the diagnostic role of the NETest and nine studies evaluating its prognostic value. The NETest emerged as a reliable biomarker for GEP-NET diagnosis with an accuracy higher than 90%, regardless of tumor stage and grade. However, according to some studies, the NETest showed a low specificity, mainly attributed to interferences with other gastro-intestinal malignancies. In terms of prognostic value, the NETest correlated with the detection of residual disease after surgery in six studies. The NETest was also associated with patients’ survival outcomes, namely progression-free survival (PFS) and overall survival (OS) in three studies. Conclusions: According to current systematic review, the value of the NETest both for diagnosis and for prognosis of GEP-NET emerged as robust across different studies. Further prospective analysis on larger GEP-NET series is encouraged to validate this tool, improving patients’ diagnosis, management, and follow-up.
The Effects of Exercise Training on Body Composition and Cardiometabolic Risk Factors in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Khalafi Mousa , Dinizadeh Farnaz , Rosenkranz Sara K. , Symonds Michael E. , Fatolahi Saeid
Published: January 2025

Introduction and Aim: We performed a systematic review and meta-analysis to investigate the effects of exercise training on body composition and cardiometabolic health in patients with Type 1 diabetes (T1D). Method: A search in three main databases including PubMed, Web of Science, and Scopus was conducted from the inception of this review until June 2024 to identify randomized control trials investigating the effects of exercise training compared to a control on body composition and cardiometabolic risk factors in patients with T1D. The data were pooled using random effects models to calculate weighted mean differences (WMDs), standardized mean differences (SMDs), and 95% confidence intervals (CIs). Results: Overall, 25 studies involving 1120 patients with T1D were included in the meta-analysis. Exercise training decreased body mass index (BMI) [WMD: −0.18 kg.m2, p = 0.02], fasting glucose [WMD: −14.97 mg/dl, p = 0.01], and HbA1c [WMD: −0.49%, p = 0.003], and increased VO2max/peak [WMD: 2.76 mL/kg/min, p = 0.001] as compared with controls. Exercise training had no effect on body fat percentage or lean body mass, lipid profiles, or blood pressure. Subgroup analysis indicated that age, exercise mode, and intervention duration were the main moderators for the beneficial effects of exercise training. Conclusions: In patients with T1D, exercise training is effective for decreasing body weight and cardiometabolic risk factors.
Olive Oil Quality Produced Under Conventional and Organic Farming Systems in a Multisite Two-Year Evaluation in Greece
Authors: Roussos Petros Anargyrou , Karyda Asimina-Georgia , Kaibalis Vassilios , Zontanos Konstantinos
Published: January 2025

Six olive groves (three conventional and three organic) of “Koroneiki” olive cultivar were selected in two different provinces in southern Greece during a two-year trial (one province per year). At harvest, the oil was extracted from olive fruits using an Abenchor-type olive mill. Olive oil quality characteristics, including free acidity, ultraviolet absorbance indexes, peroxide value, free fatty acids, total and individual phenolic compounds, antioxidant capacity, and α-tocopherol content, were assessed. During the second year, olive oil samples were stored for 12 months, and their quality was re-evaluated. Few significant differences were observed between organically and conventionally produced olive oils, while the quality of both deteriorated significantly after storage (decrease in antioxidant capacity and major phenolic compounds, except for hydroxytyrosol and tyrosol, and increase in peroxide index value). Principal component analysis revealed that, during the first year, oils produced following organic and conventional practices could be distinguished; however, this distinction was not evident during the second year. Nevertheless, significant differentiation was found between oils produced under the same cultivation practice. In conclusion, the discrepancies found in the literature regarding organic versus conventional olive oil properties probably originate from the differences detected even among similar products (organic or conventional), including high-standard deviations.
Evaluation of Statistical Models of NDVI and Agronomic Variables in a Protected Agriculture System
Authors: Gutiérrez-Castorena Edgar Vladimir , Silva-Núñez Joseph Alejandro , Gaytán-Martínez Francia Deyanira , Encinia-Uribe Vicente Vidal , Ramírez-Gómez Gustavo Andrés , Olivares-Sáenz Emilio
Published: January 2025

Vegetable production in intensive protected agriculture systems has evolved due to its intensity and economic importance. Sensors are increasingly common for decision-making in crop management and control of environmental variables, obtaining optimal yields, such as estimating vegetation indices. Innovation and technological advances in unmanned vehicle platforms have improved spatial, spectral, and temporal resolution. However, in protected agriculture systems, the use is limited due to the assumption of having controlled environmental conditions for indeterminate vegetable production. Therefore, sequential monitoring of NDVI is proposed during the 2022 and 2023 agricultural cycles using the Green Seeker® sensor and agronomic variables. This has created a database to generate predictive models of development and yield as a function of nutrient status. The results obtained indicate high significance levels for the development and NDVI curves in all phenological stages; in contrast to the yield predictive models, this is due to the maximum values (close to one) recorded for NDVI inside the greenhouse in comparison to the yield prediction obtained from the 18th week of harvest. Evaluating the models between NDVI and agronomic variables is not an index that offers certainty in predicting yield in indeterminate crops in protected agriculture production systems. This is due to the constant optimal development in response to controlled environmental conditions, nutrient status, and water supply inside the greenhouse, without the sustainability of yield, which decreases in the final stages of production until production becomes economically unprofitable.
Poison Center Surveillance of Occupational Incidents with Hazardous Materials (2016–2023): Insights for Risk Mitigation and Incident Preparedness
Authors: Wijnands Anja P. G. , Koppen Arjen , de Vries Irma , de Lange Dylan W. , Rietjens Saskia J.
Published: January 2025

Incidents involving hazardous materials (HAZMAT incidents) can impact human health and the environment. For the development of risk mitigation strategies, it is essential to understand the circumstances of such incidents. A retrospective study (2016–2023) of acute occupational HAZMAT incidents involving multiple patients (>1, including workers, emergency responders and bystanders) reported to the Dutch Poisons Information Center was conducted. We only included incidents that occurred during the performance of work or as a result of a disruption of a work-related process. Patient characteristics, exposure circumstances (such as the substances involved, chemical phase, and type of release (e.g., spill/release or fire/explosion)) and business classes were analyzed to identify risk factors. From 2016 to 2023, the DPIC was consulted about 516 HAZMAT incidents. Inhalation was the most common route of exposure (89%). Patients were often exposed to chemical asphyxiants (n = 156) and acids (n = 151). Most incidents occurred in fixed facilities (n = 447), while 49 incidents occurred during transport. The primary cause was a spill/release (n = 414), followed by a fire/explosion (n = 65). Most patients were exposed to a gas/vapor (n = 421), followed by a liquid (n = 59) or solid (n = 28). Incidents frequently occurred in industry (20%). The majority of patients reported mild to moderate health effects. Surveillance data on HAZMAT incidents are essential for incident preparedness. Poison Center data can help identify risk factors, which can be used to develop risk mitigation strategies to prevent future incidents.
Cost-Effectiveness Analysis of Photobiomodulation After Third Molar Extraction for Pain Control
Authors: Campos Thalita Molinos , Campos Mayra Costanti Vilela , Mesquita-Ferari Raquel Agnelli , Horliana Anna Carolina Ratto Tempestini , Bussadori Sandra Kalil , Duran Cinthya Cosme Gutierrez , Padilha Alexandre , Brugnera Júnior Aldo , Nammour Samir , Navarro Ricardo Scarparo , Fernandes Kristianne Porta Santos , Motta Lara Jansiski
Published: January 2025

This study aims to evaluate the cost-effectiveness of photobiomodulation applied after third molar extraction. Materials and Methods: To evaluate cost-effectiveness, 15 studies were selected for a systematic review and 8 studies for a meta-analysis to determine the effectiveness of photobiomodulation after surgery. In the present study, as a measure of effectiveness, the pain scale (visual analog scale) was used. The laser value was extracted from the Unified Terminology of Supplementary Health (Brazilian Health System) according to the laser application protocol most common among the clinical trials selected for the meta-analysis. As for drugs, they were determined from those most used among the works included in the meta-analysis and within the protocols established by the Brazilian Ministry of Health. Results: The results of the overall analysis show a significant reduction in pain on the second day after surgery for the experimental group compared to the control (MD, −1.15; 95% CI, −1.73, −0.57). The control group has a lower cost and lower effectiveness, while laser treatment has a higher cost and higher effectiveness. Faced with this situation, the professional must clinically assess whether the cost of USD 34.62 for controlled pain intensity using the laser is worth the extra health benefit. Conclusions: Regarding the cost-effectiveness assessment, the control group has a lower cost and lower effectiveness, while laser treatment has a higher cost and higher effectiveness The decision of which treatment to choose must consider whether the cost of the therapeutic alternative outweighs the clinical gain caused by the treatment. Clinical Relevance: One of the most executed procedures in dentistry is the extraction of third molars. To reduce the negative post-surgical effects, anti-inflammatory drugs are prescribed, which can generate unwanted effects. Photobiomodulation is a technique to modulate inflammation, accelerate tissue repair, and reduce pain and discomfort in different clinical situations.
Who Panics When They Think of Work?
Authors: Muschalla Beate
Published: January 2025

Work anxiety is a specific mental health problem that is often associated with sick leave and negative work perception. Until now, there has been hardly any evidence on the more general psychological characteristics of work-anxious people, i.e., in terms of life values, life satisfaction, work coping, and activity level. Learning more about these cognitive and behavioral characteristics is, however, of interest for preventive action. This present study investigates these characteristics in people with and without mental health problems and with and without work anxiety comparatively. A representative sample of 2131 persons from the German general population of working age (18–70 years old, considering that many people wish to continue work after official retirement at age 67) were investigated via an interview and self-rating questionnaire. People with work anxiety have more work participation problems in terms of unemployment (8–20% of work-anxious were presently unemployed vs. 3–10% of those without work anxiety) and sick leave (1.6–7.0 weeks in the past 12 months vs. 1.2–4.8 weeks) compared with people without work anxiety. People with work anxiety show specific patterns of negative ratings of work-associated life satisfaction (work and colleagues) and place increased value on power and the need for control. In non-work-related life domains (neighbors, friends, and environment), there are smaller satisfaction differences between people with and without work anxiety. In conclusion, work anxiety is a specific mental health problem that is associated with specific work-related participation and life satisfaction problems (partly different from people with general mental health problems). Work anxiety must be specifically assessed in order to enable preventive or interventive action.
Interrogating Healthy Community Discourse in Municipal Policies: Priorities of a Medium-Sized CMA in Ontario, Canada
Authors: Stenberg Keely , Dean Jennifer
Published: January 2025

The World Health Organization’s Healthy Cities movement recommends action on the determinants of health and health equity. While economic and ecological circumstances have been studied with respect to health outcomes, research shows that the relationship between these broad determinants and population health is not always clear. Municipal governments, whose relative proximity to individuals means that they are optimally situated to address local health concerns, can demonstrate political will for healthy communities by developing health community policies. Therefore, the aim of this study is to interrogate how the idea of a ‘healthy community’ has been conceptualized by municipal governments in order to inform the future uptake of the concept. This study uses a post-structural policy analysis to examine government discourse on healthy communities in a medium-sized census metropolitan area (CMA) in Ontario, Canada. The findings highlight economic growth and ecological sustainability as priorities for fostering a healthy community. With emphasis on long-standing issues linking health outcomes to broader societal conditions, this study calls on municipal governments to explicitly consider the health impacts of healthy community strategies and adoption of a Health-in-All-Policies (HiAP) approach.
Validating the Black Identity, Hair Product Use, and Breast Cancer Scale (BHBS) Among Black Breast Cancer Survivors
Authors: Teteh-Brooks Dede K. , Ericson Marissa , Bethea Traci N. , Dawkins-Moultin Lenna , Sarkaria Nicole , Bailey Jared , Llanos Adana A. M. , Montgomery Susanne
Published: January 2025

Personal care products containing toxic chemicals (e.g., endocrine-disrupting chemicals) may increase breast cancer risk, especially for Black women who use these products more than other racial groups. There are limited tools that examine the intersections of identity, behaviors, and attitudes surrounding product use, perceived safety, and breast cancer risk; thus, the Black Identity, Hair Product Use, and Breast Cancer Scale (BHBS) was developed to bridge this gap. While initial validations lacked diverse survivor representation, this study seeks to validate the BHBS among Black survivors. Methods: This study is a part of the Bench to Community Initiative (BCI), where respondents (n = 167) completed a 41-item survey including the BHBS between 2020 and 2022. The use of Principal Component Analysis (PCA) and confirmatory factor analysis (CFA) established the underlying component structures and model fit. CFA measures used to confirm component structures included the Root Mean Square Error of Approximation, the Comparative Fit Index, and the Tucker Lewis Index. Results: Black survivors on average were diagnosed with breast cancer before age 40 (37.41 ± 8.8) with Stage 1 (45%) disease. Sixty-three percent of the total variance resulted in a two-component structure. Subscale 1 (S1) measures the sociocultural perspectives about hair and identity (28% of the total variance; α = 0.73; 95% CI = 0.71–0.82). Subscale 2 (S2) can be used to assess perceived breast cancer risk related to hair product use (35% of the total variance; α = 0.86; 95% CI = 0.81–0.94). The two-component structure was confirmed with Root Mean Square Error of Approximation = 0.034, Comparative Fit Index = 0.93, and Tucker Lewis Index = 0.89. Discussion/Conclusions: The BHBS is a valid tool to measure identity, attitudes, and behaviors about product use and breast cancer risk among survivors. Hair is a significant cultural identity expression, and the health effects of styling products should be considered in future interventions.
Cyber Potential Metaphorical Map Method Based on GMap
Authors: Si Dongyu , Jiang Bingchuan , Xia Qing , Li Tingting , Wang Xiao , Liu Jingxu
Published: January 2025

Cyberspace maps facilitate the understanding of complex, abstract cyberspace. Due to the exponential growth of the Internet, the complexity of cyberspace has escalated dramatically. Traditional cyberspace maps are primarily for professionals and thus remain challenging for non-professionals to interpret. Ordinary users often find themselves overwhelmed by the vast amount of information and the complexity of cyberspace. This renders traditional visualization tools inadequate for the general public, thereby highlighting the urgent need for more intuitive and accessible representations. This study uses the metaphor of cyberspace as a familiar geographical space to simplify the understanding of its internal relationships. Based on Autonomous System (AS) connectivity data, a “node-link” model is created to illustrate cyber interactions and dependencies, forming a foundation for analysis. The GMap algorithm visualizes AS connectivity data of countries, converting it into an intuitive map that clearly illustrates the cyber composition and dynamics. Cyber potential and national influence are considered to enhance map practicality and accuracy. A cyber-geography metaphor model integrates scientific and geographical elements, improving readability. The optimized GMap algorithm includes a holisticcyberspace strength index, showing both connectivity and relative country strength in cyberspace. This metaphorical approach aims to reduce information complexity, making cyberspace more comprehensible to the general public.
Enhancing Precision Beekeeping by the Macro-Level Environmental Analysis of Crowdsourced Spatial Data
Authors: Kotovs Daniels , Krievina Agnese , Zacepins Aleksejs
Published: January 2025

Precision beekeeping focuses on ICT approaches to collect data through various IoT solutions and systems, providing detailed information about individual bee colonies and apiaries at a local scale. Since the flight radius of honeybees is equal to several kilometers, it is essential to explore the specific conditions of the selected area. To address this, the aim of this study was to explore the potential of using crowdsourced data combined with geographic information system (GIS) solutions to support beekeepers’ decision-making on a larger scale. This study investigated possible methods for processing open geospatial data from the OpenStreetMap (OSM) database for the environmental analysis and assessment of the suitability of selected areas. The research included developing methods for obtaining, classifying, and analyzing OSM data. As a result, the structure of OSM data and data retrieval methods were studied. Subsequently, an experimental spatial data classifier was developed and applied to evaluate the suitability of territories for beekeeping. For demonstration purposes, an experimental prototype of a web-based GIS application was developed to showcase the results and illustrate the general concept of this solution. In conclusion, the main goals for further research development were identified, along with potential scenarios for applying this approach in real-world conditions.
Combination of Low-Dose Sulforaphane and Docetaxel on Mitochondrial Function and Metabolic Reprogramming in Prostate Cancer Cell Lines
Authors: Peñata-Taborda Ana , Espitia-Pérez Pedro , Espitia-Pérez Lyda , Coneo-Pretelt Andrés , Brango Hugo , Ricardo-Caldera Dina , Arteaga-Arroyo Gean , Jiménez-Vidal Luisa , Galeano-Páez Claudia , Pastor-Sierra Karina , Humanez-Alvarez Alicia , Bru-Cordero Osnamir , Jones-Cifuentes Nathalia , Rincón-Orozco Bladimiro , Mendez-Sanchez Stelia , Negrette-Guzmán Mario
Published: January 2025

Considering the limitations of monotherapies due to chemoresistance and side effects, this research aimed to determine whether low doses of sulforaphane (SFN) combined with docetaxel (DCT) could enhance therapeutic efficacy. Prostate cancer cell lines LNCaP and PC-3 were treated with individual IC50 doses of SFN and DCT and half-reduced IC50 values for the SFN:DCT combination. Metabolic markers, including glucose consumption, lactate production, reactive oxygen species (ROS), mitochondrial mass, and caspase activity, were assessed. In LNCaP cells, the SFN:DCT combination reduced cell viability to 50%, comparable to DCT monotherapy (48%). Caspase 3 activation was also higher with SFN:DCT (2.4 ± 0.75 RFU) than DCT alone (2.1 ± 0.47 RFU), while caspase 8 activation remained comparable, indicating equivalent effectiveness at lower concentrations. In PC-3 cells, the combination induced caspase 3 activation (1.16 ± 0.0484 RFU) at levels slightly lower than DCT (1.51 ± 0.2062 RFU) but achieved greater reductions in mitochondrial mass, reflecting its ability to target metabolic vulnerabilities in aggressive phenotypes. Our findings suggest that the SFN:DCT combination is a promising strategy for early-stage prostate cancer. By achieving comparable efficacy to DCT monotherapy at low doses, the SFN:DCT combination maintains the therapeutic impact, mitigating the adverse effects of conventional DCT treatment.
The Basis of Diversity in Laminopathy Phenotypes Caused by Variants in the Intron 8 Donor Splice Site of the LMNA Gene
Authors: Shchagina Olga , Gilazova Leisan , Filatova Alexandra , Vafina Zulfiia , Murtazina Aysylu , Chigvintceva Polina , Kudryashova Olga , Polyakov Aleksander , Kutsev Sergey , Bulakh Maria , Skoblov Mikhail
Published: January 2025

Laminopathies are a broad spectrum of hereditary diseases caused by pathogenic variants of the LMNA gene. Such phenotypic diversity is explained by the function of intermediate filaments encoded by the LMNA gene. We examined a family with an overlapping phenotype of cardiac arrhythmia, cardiomyopathy, limb–girdle muscular dystrophy, and partial lipodystrophy. The cause of the disorder was a novel LMNA(NM_170707.4):c.1488+2T>C variant. The analysis of mRNA extracted from the probands’ blood showed a multitude of alternative splicing products, which was the cause of the complex phenotype in affected family members. Aside from that, we used minigene constructs to analyze the c.1488+2T>C variant, as well as other previously described variants affecting the same donor splice site in intron 8 (c.1488+1G>A, c.1488+5G>C, c.1488+5G>A). We demonstrated that these variants result in multiple splicing events, each producing splicing products with varying prevalence. Our experiments suggest that the variety of alternative transcripts contributes to complex phenotypes, while the quantitative ratio of these transcripts influences the varying severity of the disease.