bluuebunny/crossref_metadata_2025 huggingface dataset:
دور الجامعة في تعزيز قيم المواطنة لدى عينه من طلبة الجامعة
Authors: كطفان شون هادي
Published: November 2022

هدف البحث الى التعرف على دور الجامعة في تعزيز قيم المواطنة لدى عينه من طلبة الجامعة من وجهة نظرهم, وتكون مجتمع البحث من طلاب جامعة القادسية للعام الدراسي 2014- 2015, اختار الباحث عشوائيا 100 طالبا منهم, استخدم الباحث الاستبيان كأداة لبحثه المتكونة من 30 فقرة في أربع مجالات (مجال العدالة, مجال الواجبات, مجال احترام القانون, مجال الحقوق تم التاكد من صدقها وثباتها ,استخدم الباحث الحقيبة الإحصائية spss لحساب القيمة التائية لتمييز الفقرات ومعامل الفا كرونباخ لإيجاد الثبات ومعامل ارتباط بيرسون لحساب علاقة الفقرة بمجالها وبالدرجة الكلية للمقياس والمتوسط الحسابي والانحراف المعياري والنسبة المئوية ,استنتج الباحث ان الجامعة تتبنى المواطنة كحرية التعبير عن الرأي وحقوق الإنسان، خاصة في بعض القضايا الجدلية، كقضايا التظرف الفكري مثلا وان هناك ضعفا في الأنشطة الطلابية التي تعزز قيمة نبذ العنف والتمييز بكل أشكاله , وأوصى ببعض التوصيات والمقترحات
سيميائية العنوان في ديوان (كانت لنا.. اوطان ) للشاعر فاروق جويدة
Authors: كاظم سلمان احمد
Published: November 2022

العنوان هو البوابة الأولى للدخول الى النص وهو جزء من النص بل هو نص بحد ذاته يمتلك أمكانية تختلف عن ما أريد به النص ، ولأهميته حاول الشاعر أن يتخذ اساليب مختلفة من خلالها يقوم بالدخول الى ذهن المتلقي  وجذبه محفزا أياه على المواصلة من خلال  استعمال أساليب قصدية تجعل المتلقي يغور في أستار النص المتخفي من أجل رصد جماليات ذلك النص وشعريته ، لذلك جاءت هذه الدراسة محاولة الكشف عن قدرة الشاعر في استعماله العنوانات  ومدى أرتباطه في النص الشعري ، رغم وجود دراسة للشاعر نفسه في مجاميعه الشعرية الأخرى لكن أهمل هذا الديوان (كانت لنا أوطان ) ومن خلال هذا البحث نحاول الكشف عن مميزات العنوانات وما تحمله من غنى ثقافي ومعرفي حيث شكل العنوان حضورا مميزا في الديوان.
Differential expression of ZNF688 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of ZNF688, encoding zinc finger protein 688, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. ZNF688 was also differentially expressed in fibroblasts isolated from patients with ALS. ZNF688 transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
The COVID States Project #94: American attitudes towards Russia's invasion of Ukraine
Authors: Schulman Jonathan , Lazer David , Perlis Roy , Baum Matthew , Cadenasso Samantha , Ognyanova Katherine , Quintana Alexi , Uslu Ata , Druckman James , Santillana Mauricio , Green Jon , Safarpour Alauna , Trujillo Kristin Lunz , Qu Hong
Published: November 2022

KEY TAKEAWAYS1. Despite being featured less in popular news media, Americans remain concerned about Russia’s invasion of Ukraine, with 78% reporting that they are either somewhat or very concerned.2. In response to a hypothetical Russian use of nuclear weapons, there was broad bipartisan agreement for an aggressive response, even if it meant more direct NATO or American involvement.3. While Democrats are more concerned about the Russian invasion of Ukraine than Republicans and independents, strong majorities in all three groups report being concerned. Majorities of Republicans, Democrats, and independents across every age group are concerned about the invasion.4. In the event of a Russian nuclear attack, Republicans and Democrats both indicated support for tightening economic sanctions, increasing military aid to Ukraine, launching missile strikes aimed at taking out nuclear weapons that Russia could use on the battlefield in Ukraine, establishing a NATO-led no fly zone in Ukraine, and sending NATO troops to Ukraine. Very few indicated support for withdrawing all military aid from Ukraine.5. Americans across all age groups are concerned about the Russian invasion of Ukraine, but especially those 65 and older, where an overwhelming majority is concerned.6. Women are more likely than men to report being concerned over the invasion. Specifically, Republican and independent women are significantly more likely than Republican and independent men to report being concerned about the Russian invasion. Even so, concern among men is still high, with 75% reporting being somewhat or very concerned about the Russian invasion of Ukraine.7. Majorities of Americans across different levels of education all report concern over the invasion, but more highly-educated individuals are more likely to report being very concerned.
Kerangka Kerja Kebijakan Moneter Islam
Authors: Resky Andi Sry Aska
Published: November 2022

Fokus utama kebijakan moneter dalam Islam yakni pada pemeliharaan perputaran sumber daya dengan hukum-hukum syariah seperti ketiadaan suku bunga dalam ekonomi, sehingga tidak ada lagi alasan bagi para pemegang dana untuk menahan uangnya di pasar keuangan.
Sex and gender considerations in a COVID-19 clinical trials registry
Authors: Gogovor Amédé
Published: November 2022

To assess “sex” and “gender” considerations in registered COVID-19 clinical trials. The data source was the WHO International Clinical Trails Registry Platform for COVID-19 trials registry (retrieved on 28 July 2020). Sex- and gender-related terms were searched in relevant fields of the registry. A content analysis was conducted. Less than one per cent of the trials (<1%) used sex- and gender-related terms in the title.
Resume Ekonomi Mikro Syariah Pasar Persaingan Sempurna
Authors: Rusli Rezky Kurniati
Published: November 2022

Pasar persaingan sempurna yaitu sebuah struktur pasar di mana terdapat banyak penjual dan pembeli dan setiap penjual atau pembeli tidak dapat mempengaruhi keadaan di pasar.
Specificity of Brain Volume Alterations in Children with Various Parental Histories of Psychopathology
Authors: Mattoni Matthew , Hopman Helene Janine , Dadematthews Adefunke , Chan Sandra , Olino Thomas M
Published: November 2022

Background: Multiple forms of parental psychopathology have been associated with differences in child subcortical brain volume. Much of this work has relied on studies of individual forms of parental psychopathology without considering the role of comorbid disorders. Here, we examine the specificity of relationships between multiple forms of parental psychopathology and alterations in child subcortical brain structure. Method: We examined 6581 children from the ABCD study with no history of mental disorders. Hierarchical linear models were used to examine whether neuroanatomical correlates of parental history of depression, anxiety, mania, and alcohol/substance use are disorder-specific or general across different disorders, and whether interactions between parental disorders were associated with offspring brain structure. Results: There were several significant interactions such that the effects of parental histories of depression, anxiety, and substance use problems on the volume of the amygdala and striatal regions were moderated by comorbid parental history of another disorder. Additionally, a parental history of depression was associated with smaller amygdala volume and a parental history of mania was associated with larger amygdala, pallidum, thalamus, and total subcortical volume before and after controlling for histories of other parental disorders. Conclusion: Results suggest that effects of a parental history of various forms of psychopathology on offspring subcortical brain volume are moderated by comorbid history of other disorders, highlighting the importance of assessing multiple forms of psychopathology when examining neurobiological associations. A limitation is that measures of parental psychopathology did not come from gold standard interview assessments and lacked information of timing, duration, and severity.
MAKALAH INDAH KHAIRUNNISA GAMBARAN PENGETAHUAN MAHASISWA KEPERAWATAN TENTANG HIGH QUALITY CARDIOPULMONARY RESUSCITATION (CPR)
Authors: Khairunnisa Indah
Published: November 2022

Berdasarkan hasil penelitian yang telah dilakukan pada mahasiswakeperawatan di Politeknik Kesehatan Riau Kementerian KesehatanRepublik Indonesia, maka dapat disimpulkan sebagai berikut:1. Resusitasi mengandung arti harfiah “Menghidupkan kembali”tentunya dimaksudkan usaha-usaha yang dapat dilakukan untukmencegah suatu episode henti jantung berlanjut menjadi kematianbiologis.2. Resusitasi jantung paru terdiriatas 2 komponen utama yakni, BantuanHidup Dasar (BHD) dan Bantuan Hidup Lanjut (BHL).3. Usaha Bantuan Hidup Dasar bertujuan dengan cepat mempertahankanpasok oksigen ke otak, jantung dan alat-alat vital lainnya sambalmenunggu pengobatan lanjutan.4. Bantuan hidup lanjut dengan pemberian obat-obatan untukmemperpanjang hidup Resusitasi dilakukan pada infark jantung“kecil” yang mengakibatkan “kematian listrik”, serangan AdamsStokes, Hipoksia akut, keracunan dan kelebihan dosis obat-obatan,sengatan listrik, refleks vagal, serta kecelakaan lain yang masihmemberikan peluang untuk hidup.5. Resusitasitidak dilakukan pada kematian normal stadium terminalsuatu yang tak dapat disembuhkan.6. Penanganan dan tindakan cepat pada resusitasi jantung parukhususnya pada kegawatan kardiovaskuler amat penting untukmenyelematkan hidup, untuk itu perlu pengetahuan RJP yang tepatdan benar dalam pelaksanaannya.7. Basic Life Support (BLS) boleh dilakukan oleh orang awam dan jugaorang yang terlatih dalam bidang kesehatan.
Differential expression of LOC100506235 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of LOC100506235 in the motor neurons of patients with ALS. LOC100506235 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. LOC100506235 transcript was present at significantly lower levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Pengaruh Laju Aliran Gas Terhadap Nilai Kekerasan Baja Karbon Rendah Hasil Hardfacing Dengan Pengelasan GTAW
Authors: Adamsyah Zefano Andra , Nasrudin Adji Iqbal Muhammad , sadewo Mustofa bagus , Febriansyah Khoirul Nola
Published: November 2022

Pengaruh Laju Aliran Gas Terhadap Nilai Kekerasan Baja Karbon Rendah Hasil Hardfacing Dengan Pengelasan GTAW. Pogram Studi Teknik, Fakultas Teknik, Universitas Muhammadiyah Malang, November 2022 Penelitian ini bertujuan untuk mengetahui ada atau tidaknya pengaruh yang terjadi akibat adanya variasi laju aliran gas terhadap nilai kekerasan baja karbon rendah. Metode yang digunakan pada penelitian ini adalah metode eksperimen.Berdasarkan hasil penelitian yang didapat adalah Laju aliran gas 1 liter/menit menghasilkan nilai kekerasan paling tinggi pada baja karbon rendah yang telah di heat treatment, yaitu sebesar 88 HRB.Laju aliran gas 3 liter/menit pada karbon rendah menghasilkan nilai kekerasan sebesar 83 HRB, sedangkan laju aliran gas 5 liter/menit, menghasilkan nilai kekerasan sebesar 70 HRB.Baja tanpa heat treatment yang dilas dengan laju aliran gas 1 liter/menit menghasilkan nilai kekerasan sebesar 82 HRB.Laju aliran gas 3 liter/menit pada baja tanpa perlakuan panas menghasilkan nilai kekerasan sebesar 76 HRB, sedangkan laju aliran gas 5 liter/menit menghasilkan nilai kekerasan sebesar 65 HRB.
Loneliness during COVID-19 influences mind and likeability ratings in the Uncanny Valley
Authors: Abubshait Abdulaziz , Wiese Eva
Published: November 2022

To combat the spread of the COVID-19 virus, countries enforced quarantines, physical and social restrictions on people. These restrictions left many feeling isolated and lonely due to prolonged quarantines and lockdowns. This raises questions about using robots as social support to alleviate these symptoms, while still complying with restrictions and regulations. Since acceptance of social robots as companions has traditionally been low, an event like COVID-19 could change acceptance of robots as social companions as loneliness can influence the likelihood of anthropomorphizing nonhuman agents. Here, we aimed to see if loneliness, due to COVID-19 restrictions, influence the Uncanny Valley pattern that prior work has shown. As such, participants saw robot images that varied in physical human-likeness and were asked to evaluate them regarding trustworthy-ness, mind perception and likability. The measurements were obtained once be-fore COVID-19 (in 2016) and once at the peak of the pandemic in September 2020. Results show that ratings of mind perception and likability were significantly impacted by the pandemic, with less pronounced UV patterns for those who experienced the COVID-19 pandemic. However, no differences in the UV pattern was observed on trust. Post-hoc analyses also illustrated that people were more likely to judge machinelike robots negatively, which could be due to in-creased loneliness/anxiety. These data suggest that loneliness attenuates UV pat-terns that are observed in “Uncanny” robots and that people have more favorable attitudes towards humanlike robots when feeling lonely, which provides important considerations for the use of humanlike robots as social companions.
PENGANTAR PERJANJIAN BARU PENDEKATAN KRITIS TERHADAP MASALAH-MASALAHNYA
Authors: Restu Toya
Published: November 2022

Judul “kepada orang ibrani” jelas bersifat sekunder. Namun ini berguna kendati sementara ini kita tidak usah memperlihatkan acuan khusus kepada para penerimanya untuk mencirikan dokumen ini sebagai sebuah surat dan membaurkannya secara formal dengan surat-surat Paulus dengan menunjuk pada penerimanya dalam suatu lingkungan khusus, yang sesungguhnya merupakan ciri khas dari surat-surat Paulus.
POSTMODERN TENTANG KONSEP SOSIOLOGI MODERN
Authors: Pesik Anggreiny Veronika
Published: November 2022

Jean-Francois Lyotard adalah orang yang memperkenalkan postmodernisme dalam bidang filsafat dan ilmu pengetahuan di tahun 1970-an dalam bukunya yang berjudul “The Postmodern Condition: A Report on Knowledge”. Dia mengartikan postmodernisme sebagai segala kritik atas pengetahuan universal, atas tradisi metafisik, fondasionalisme maupun atas modernisme(Maksum, 2014: 305-306). Menurut beberapa para ahli yang lainnya, seperti Louis Leahy, postmodernisme adalah suatu pergerakan ide yang menggantikan ide- ide zaman modern (Leahy, 1985: 271). Menurut Emanuel, postmodernisme adalah keseluruhan usaha yang bermaksud merevisi kembali paradigma modern (Emanuel, 2006: 93).
Origins of the Internet (historiography VIII:2 - part two)
Authors: Akmut Camille
Published: November 2022

Computer science and technology : historiography VIII (2 - part two) including interviews of key staff from ARPA, UCLA, BBN...
Linking technology usage to instructional quality: Immersive virtual reality increases presence, positive emotions, and cognitive activation
Authors: Büssing Alexander Georg , Thomsen Dorian , Braun Nicole
Published: November 2022

Technologies such as immersive virtual reality (IVR) pose new challenges to educators and researchers. While there are mixed results concerning the consequences of integrating IVR into education, the present study proposes a new direction in this field, by combining research on presence – the feeling of being in a specific environment – with instructional quality. In a controlled experimental study, we show how the integration of IVR in contrast to text and tablets increases presence, positive emotions (interest and enjoyment), and indirectly affects clarity as a dimension of cognitive activation. Given the results, studies on the effects of IVR should not only focus on direct reactions and learning outcomes, but also take other established educational paradigms (e.g., instructional quality) into account.
Patients with multidrug-resistant organisms feel inadequately informed about their status: Adverse effects of contact isolation
Authors: Gaube Susanne , Däumling Sara , Biebl Isabell , Rath Anca , Caplunik-Pratsch Aila , Schneider-Brachert Wulf
Published: November 2022

Background: Contact isolation of patients with multidrug-resistant organisms (MDROs) is an essential element of infection prevention strategies in hospitals worldwide. However, this practice may be associated with adverse side effects on patients’ health and well-being.Aim: This study is the first to assess mental health and well-being variables among isolated patients compared to non-isolated control patients in a German cohort.Methods: We conducted a matched case-control study among N = 267 patients admitted to a tertiary care teaching hospital in Germany. Their levels of anxiety, depression, loneliness, and dissatisfaction with their hospital experience were assessed using a questionnaire. Additionally, among isolated patients, it was evaluated how well they felt informed about their MDRO status.Findings: In our cohort, patients under contact isolation were significantly more dissatisfied than non-isolated control patients but did not show higher levels of anxiety, depression, and loneliness. A large proportion of patients felt insufficiently informed about their MDRO status. This lack of information was the strongest predictor of dissatisfaction among isolated patients.Conclusion: These findings underline the importance of adequate patient communication. It is essential for patients’ well-being to receive timely, relevant, and understandable information about the background and consequences of their infection or colonisation with MDROs.
PENGARUH JENIS ELEKTRODA DAN BESAR AMPERE UNTUK UJI KEKUATAN TARIK PADA PENGELASAN SMAW (SHIELD METAL ARC WELDING) TERHADAP BESI HOLLOW 1.2 MM
Authors: Anam Elmi Iftachul , Marich Achmad Hilal , Razzaq Muhammad Raihan Abdur , Arya Muhammad
Published: November 2022

PENGARUH JENIS ELEKTRODA DAN BESAR AMPERE UNTUK UJI KEKUATAN TARIK PADA PENGELASAN SMAW (SHIELD METAL ARC WELDING) TERHADAP BESI HOLLOW 1.2 MM, Program studi Teknik Mesin Fakultas Teknik, Universitas Muhammadiyah Malang Tahun 2022, Penelitian ini bertujuan untuk mengetahui ada atau tidaknya pengaruh dari jenis elektroda yang digunakan pada saat proses pengelasan SMAW terhadap kekuatan uji tarik tidak hanya jenis elektroda saja namun pada besar kecilnya ampere juga akan di lakukan penelitian, untuk objeknya sendiri yaitu besi hollow dengan ketebalan 1.2mm, untuk jenis dari elektroda sendiri ada beberapa macambya seperti RD 460, RD 260, RB 320 dan masih banyak lainnya sedangkan untuk besar ampere sendiri biasanya untuk inverter las 450 Watt sendiri mempunyai besatan 10 – 120 Ampere, dari sini bisa dilakukan penelitian seberapa tahan atau kuat pengelasan tersebut pada uji tarik yang akan dilakukan.
Epistemic Agency and the Generalisation of Fear
Authors: Puddifoot Katherine , Trakas Marina
Published: November 2022

Fear generalisation is a psychological phenomenon that occurs when fear that is elicited in response to a frightening stimulus spreads to similar or related stimuli. The practical harms of fear generalisation are well-documented, but little or no attention has been given so far to its epistemic harms. This paper fills this gap in the literature. It shows how the psychological phenomenon substantially curbs the epistemic agency of those who experience it, limiting their ability to respond to evidence, and substantially limiting their epistemic horizons. It is argued that when these epistemic harms are caused by wrongful actions and decisions of individuals or institutions, because the fear is elicited in response to a traumatic experience inflicted by them, the harms should be considered epistemic wrongs. The epistemic wrongs are closely akin to agential epistemic injustice, a variety of distributive epistemic injustice, and sometimes also involve epistemic exclusion. The paper thereby identifies a previously underexplored psychological mechanism that can be a vehicle through which both individuals and institutions can epistemically wrong others. The argument has implications for how both epistemic wrongs and epistemic injustice should be conceived, suggesting that both can occur without primarily being caused by epistemic flaws or errors, or a bad epistemic character. Finally, it highlights the advantage of taking a victim-centred approach to understanding epistemic harm.
Zooming in on everyday ethnic-racial discrimination: A review of experiencing sampling methodology studies in adolescence
Authors: Civitillo Sauro , Jugert Philipp
Published: November 2022

This is the first review that takes stock of studies that have applied an experience sampling methodology (ESM) to examine the consequences of daily ethnic-racial discrimination (ERD) on youth’ psychological adjustment and academic outcomes. We summarise moderators and mediators of these associations, and highlight the benefits and limitations of employing ESM to examine ERD in comparison to traditional between-person methodologies. A total of 18 studies published between 2010 and September 2022 were identified and reviewed. These studies document the negative effects of experiencing ERD on a daily basis, but also that variations exist depending on the moderators accounted for in the analyses. Although the use of ESM has great potential for the understanding of everyday ERD among adolescents, this line of research requires more evidence on contextual characteristics, mediating mechanisms, and with a wider variety of ethnic-racial groups.
Separating Social Consensus from Unshared Perceptions of Everyday Situations with Interrater Agreement
Authors: Ringwald Whitney R. , Pilkonis Paul A. , Wright Aidan G.C.
Published: November 2022

Perceptions of situations are a critical mechanism linking persons and situations. Many personality theories assume that the abstractness of situational attributes is a key dimension that magnifies or minimizes individual differences in how people respond to situation¬s. In this pre-registered study, we evaluated this basic property of situations and situation-perception processes by examining interrater agreement on in-situ ratings of situation features in everyday life varying in abstractness. We studied a sample of 94 romantic couples who rated their interactions with one another multiple times per day for 21 days. We used multi-level structural equation modeling to quantify the degree of social consensus on location, whether others were present, duration of interaction, and conversation topic. Results showed that (1) situation attributes vary in the extent of socially consensual vs. unshared meaning, and (2) there is more social consensus on less abstract situation attributes and more unshared perceptions of more abstract attributes.
Mental models and the algorithms of deduction
Authors: Johnson-Laird Philip Nicholas , Khemlani Sangeet
Published: November 2022

Pose the following problem to a smart eight-year-old: "All machines can break down. Alexa is a machine. What follows?" and the child is likely to reply: "Alexa can break down." So, as experiments confirm, human beings unschooled in logic are able to make deductions. Yet, this easy deduction defeats Alexa, Siri, and other virtual assistants. To build machines that reason, students of reasoning need to know the answers to three questions: (1) Which deductions do human reasoners make? (2) How do they make them? And (3) How can computers simulate them? The goal of this chapter is to describe the main efforts to simulate human deduction. It aims to provide its own intellectual life-support system so readers can understand it without having to consult anything else.
Environmental and Social Aspects of the Conflict in Ukraine: an Update
Authors: Jargin Sergei V.
Published: November 2022

This update attempts to analyze social, historical and environmental aspects of the conflict in Ukraine, formulating proposals potentially conductive to peace initiatives and prevention of conflicts. Should the power in Eurasia be displaced to the East, it will come along with losses of values like liberties and human rights. Quality of many services, products and foodstuffs would decline. The environmental protection and energy conservation is less popular in Russia than in other industrialized countries. The reason of the “special military operation” started February 2022 was the anti-separatist activity by the Ukrainian army in Donbas since 2014. In principle, the fight against separatism within national borders is justifiable. Ukraine in her 1991 borders was recognized by all nations including Russia. However, another argumentation is also possible. The Ukraine in today’s borders was created in 1918 disregarding ethnic and linguistic realities. A majority of residents in southern and eastern provinces are Russian-speaking. Many people in Donbas were disappointed that their region had not become a part of the Russian Federation. Recent referendums on occupied territories have been met with skepticism. The Soviet-trained collectivism and mass intimidation influences referendums and elections. Many residents of occupied territories voted for the unification with Russia to avoid personal trouble as they don’t believe that the situation will be reverted. A workable solution would be an international agreement delimitating spheres of influence. Some areas in the East and South of today’s Ukraine should belong to the Russian sphere of influence as the majority of residents are ethnically and linguistically Russians. If the world is becoming multicentric, armed conflicts of various magnitudes may become permanent. A reasonable alternative is a global leadership centered in the most developed parts of the world, based on humanism and modern science.
Colistin Resistance among Human Clinical Isolates from a Tertiary Care Hospital in Nepal
Authors: Amatya R. , Barakoti A. , Rai J. R. , Subedi A.
Published: November 2022

Background Colistin is increasingly being used for treatment of multidrug resistant (MDR) bacterial infections in human. The plasmid mediated mcr-1 gene was detected recently among the poultry in Nepal. Plasmid mediated colistin resistance among human isolates would severely compromise the treatment of MDR bacterial infections.

Objective To find out the prevalence of colistin resistance among the gram-negative bacteria isolated from clinical specimen.

Method A descriptive cross-sectional study was conducted in a tertiary care hospital in Kathmandu. Colistin resistance among all the gram negative bacilli (GNB), isolated in a year, from all clinical specimen subjected for aerobic bacterial isolation, was detected by disc diffusion and agar dilution methods. Those with a minimum inhibitory concentration (MIC) > 2 mcg/ml were subjected to polymerase chain reaction for detection of mcr-1 gene.

Result A total of 1993 aerobic GNB were isolated from clinical samples received from February 2018 to January 2019. By the agar dilution screening method, 2.1% of the GNBs isolated had MIC of colistin > 2 mcg/ml. None of these possessed the mcr-1 gene.

Conclusion Given the occurrence of increased MIC of colistin in the clinical isolates in our set up, nationwide active surveillance would generate data for Nepal. The study for the presence of other genes (chromosomal or plasmid mediated) responsible for the increased MIC of colistin would further guide the control measures.
Real Time Trans-Rectal Elastography of Prostate Correlation with Histopathology in a Suspected Case of Prostate Cancer
Authors: Basnet B. , Suwal S. , Chataut D. , Lohani B. , Paudel S.
Published: November 2022

Background Early detection of prostate cancer, the second most common cancer in men worldwide, is the key for its successful treatment. Commonly used clinical criteria and imaging tools for detection of prostate cancer are less sensitive.

Objective This study was aimed to find role of real time transrectal elastography of prostate for detection of prostate cancer.

Method Study was conducted in 66 patients with clinical suspicion of prostate cancer, who were sent for ultrasound guided prostate biopsy. Transrectal ultrasound with real time elastography was performed in all the patients prior to the biopsy and looked for hard areas within the prostate. Then six-core tru-cut biopsy were taken in six zones of prostate, including the hard areas detected in the elastography. The histopathology report were correlated with the elastography findings.

Result Median prostate specific antigen of the patients was 11.5 ng/ml with interquartile range of 8 to 23.5 ng/ml. Digital rectal examination showed hard nodular findings in 35 patients. Transrectal ultrasound showed 81 hypoechoic lesions in 31 patients. Elastography showed 127 hard areas in 31 patients. Histopathology showed 90 positive biopsy cores in 23 patients. Cancer detection rate of elastography was 82.6%. At 95% confidence interval, patients with elastography detected hard lesions had 19.4 times more likelihood to have prostate cancer. Sensitivity of elastography was high as compared to digital rectal examination and transrectal ultrasound alone.

Conclusion Transrectal elastography had high sensitivity over clinical tools and transrectal ultrasonography for detection of prostate cancer.
Clinical Profile and Diagnosis of Obstructive Sleep Apnea Syndrome using Overnight Polysomnography in a Tertiary Care Hospital
Authors: Pokharel M. , Shrestha B. L. , Dhakal A. , Rajbhandari P. , Shrestha K. S. , KC A. K. , Bhattarai A. , Karki D. R.
Published: November 2022

Background Obstructive sleep apnea is a highly prevalent yet largely under-diagnosed disease that poses a significant burden on the healthcare system.

Objective To determine the role of predictors for Obstructive sleep apnea syndrome and its severity in Nepalese population.

Method Prospective and analytical study conducted in the Department of Otorhinolaryngology and Head and Neck surgery at Kathmandu University Hospital between March 2018 and June 2020. A total of 85 adult patients with Obstructive sleep apnea with an Epworth sleepiness score greater than 10 were included. Overnight polysomnography was done and scoring of sleep associated events were done according to the American Academy of Sleep Medicine criteria. Participants were classified as simple snoring and mild, moderate or severe Obstructive sleep apnea syndrome groups depending on the Apnea Hypopnea Index values. Relationship of Apnea hypopnea index was analyzed with age, neck circumference, body mass index and Epworth Sleepiness score.

Result Simple snoring was seen in 18(21.17%) patients, 14(16.47%) had mild Obstructive sleep apnea, 13(15.29%) had moderate Obstructive sleep apnea, whereas the severe group consisted of 40(47.05%) patients. The minimum Epworth Sleepiness Score was 10 and the maximum was 25. The Apnea hypopnea index correlated positively with Body mass index (p=.010) and Epworth sleepiness score (p<.001). However, Apnea hypopnea index had no association with age (p=.437) and neck circumference (p=.118).

Conclusion Health professionals need to be extremely vigilant while examining patients presenting with Obstructive Sleep Apnea. Polysomnography is the investigation of choice in the early identification of this treatable disease.
Psychosocial Problems among the Adolescent School Students of Dhulikhel Municipality
Authors: Shrestha B. , Gautam S. , Shrestha J. , Shrestha S.
Published: November 2022

Background Adolescence is a period when an individual experiences a variety of biological, psychological and social changes. These multiple changes during the developmental period can make the adolescents vulnerable to mental health problems. Therefore early detection of psychosocial problems and addressing the need of the adolescents are crucial for promoting their mental health.

Objective To assess psychosocial problems and its associated factors among school going adolescents of Dhulikhel, Nepal.

Method A descriptive cross sectional study was conducted among 513 adolescents studying in grade 8 to 12 of randomly selected schools of Dhulikhel Municipality. Data were collected by using structured questionnaire and Pediatric Symptom Checklist-Youth Report (Y-PSC). Descriptive and inferential analysis was done using Statistical Package for Social Sciences version 20.

Result Out of 513 adolescent students, a total of 133(25.9%) of the adolescents were found to have psychosocial problems. There was significant association between psychosocial problems and respondents’ variables like age, grade, parental education status, respondents’ living status, perceived family disputes, perceived marital problems of parents, relationship problem with family, stress of failure in study, punishment faced in home and school, experienced sexual harassment and death of loved ones.

Conclusion Various family related factors and stressful life events of adolescents are associated with the psychosocial problems. Hence early intervention focusing on awareness and modification of stressful life events is required.
C-ARM Guided Angiogram/Angioplasty for Selected Failed Arterio Venous Fistula. A Report of a Procedure at University Hospital of Nepal
Authors: Vaidya S. , Karmacharya R. M. , Singh A. K. , Vaidya P. R. , Malinowski M. , Dhakal A.
Published: November 2022

End Stage Renal Disease is a last stage of Chronic Kidney Disease which is characterized by Glomerular Filtration rate of less than 15 ml/min/1.73 m2. Hemodialysis is the most commonly used modality for treatment of Chronic Kidney disease. Among the access for hemodialysis arteriovenous fistula is the most common modality. However most common problems of fistula are significant stenosis of more than 50% which is characterized by limb swelling, pigmentation, tortuous veins, and difficulty maintaining flow during dialysis from AV fistula. These can be managed either by minimal intervention or with surgical intervention. Very few hospitals in Nepal and other countries have an angiographic suite to perform minimal intervention include angiogram with angioplasty. So in this case we try to address the use of C-Arm to perform angiogram or fistulogram and even angioplasty for the management of significant stenosis or complications of arteriovenous fistula.
PROSPECTIVE DIRECTIONS AND FORECAST OF THE MAIN
PARAMETERS OF THE GAS MARKET DEVELOPMENT
Authors: Bannikova Natalia , Vorobyeva Natalia , Sevostyanova Victoria
Published: November 2022

Introduction. The problem of overcoming negative trends in natural gas trade in the domestic and foreign markets, which arose against the background of the spread of the COVID-19 coronavirus, is extremely important for the Russian economy. This article analyzes the key parameters of the gas market development, substantiates the forecast of indicators characterizing the demand in this market, and considers the possible directions of its development. Methods. In the process of researching trends and forecasting in the field of domestic consumption and export of natural gas, trend analysis was used in combination with the study of expert opinions. Results. The analysis of the development and existing difficulties in the gas industry in the world and the Russian Federation is presented. Based on the dynamics of the volumes of consumption of Russian domestic gas, exports of pipeline and liquefied gas, the equations for forecasting these processes are compiled. Conclusions. The positive development of the situation on the domestic market is associated with the implementation of projects in the field of gas processing and gas chemistry, the development of the gas transmission system and the consumption of gas engine fuel. In the field of export, it is necessary to revise the geography of trade and to advance the development of liquefied gas production.
DECISION-MAKING IN INNOVATION MANAGEMENT
Authors: Kenina Diana , Babkina Olga , Zaporozhets Dmitriy , Zvyagintseva Olga
Published: November 2022

Introduction. One of the important problems of both the head of a modern company and subordinates is the ability to make the right decisions, because the future of the company depends on the chosen options of actions. Erroneous actions can not only hinder the development of the company, but also contribute to its closure. It is worth highlighting the decisions that are made in the field of innovation and innovation activity of enterprises and organizations. Goals. Research of the decision-making process in innovation management, identification of its main trends in the territory of the Russian Federation and the Stavropol Territory, as well as the development of the sequence of the decision-making process on the introduction of innovations. Methodology. In the process of research, the issue of decision-making in innovation management, methods of logical and statistical analysis were applied. Results. The analysis of innovative activity of enterprises is carried out, an up-to-date brief description of the sphere of innovation is given, the main barriers to the development of innovation activity in the Russian Federation as a whole and in the Stavropol Territory in particular are identified, a detailed algorithm for making decisions about innovations taking into account risk factors and uncertainty is proposed. Conclusions. When making decisions in the field of innovation, it is important to comprehensively study the issue, assess all possible risks and negative consequences, observing the classical sequence of decision-making, namely: data preparation and analysis (observation and search, data filtering, problem statement), problem statement and development of alternatives (classification of influencing factors, search for solutions (forecast and evaluation of alternatives), decision-making (choice of alternatives, generalization of criteria, choice of solution).
ROLE OF THE THIRD MISSION OF THE BRANCH UNIVERSITY IN THE DEVELOPMENT OF THE REGIONAL ECONOMY
Authors: Shumakova Oksana , Kryukova Olga , Nardin Dmitriy , Mozzherina Tatiana
Published: November 2022

Subject. The problem of the development of the regional economy is of great importance for all participants living and working within the borders of the territory. Each subject of the ecosystem should contribute to the development of the region in proportion to financial stability, receiving image and investment bonuses. In this article, the algorithm of the influence of the branch university on the rate of improvement of the welfare of the population in the Omsk region is considered. In the article, the authors prove the hypothesis that the achievements of university science are a key factor in the development of the region in the conditions of a new knowledge economy and limited human and financial resources. Methodology. Methods of induction and deduction, analysis and generalization were used in the process of studying the problem of the development of the regional economy. Results. Five global trends were identified for the development of higher education and science at Omsk State Agrarian University named after P.A. Stolypin. Project competencies have been developed – both traditional and expected, as well as frontier development of IT solutions. The desire for collaboration with other organizations and the creation of an effective ecosystem of external relations is proved. The course of implementation of “digital” projects at Omsk State Agrarian University named after P.A. Stolypin is analyzed. Conclusions. It is concluded that a collaborative approach to the interaction of all institutions within the regional economy is applicable for an industrially saturated region, will effectively solve the issue of national environmental and food security, will become a new vector of development.
Pendampingan Peningkatan Pemasaran melalui Strategi Labeling Produk Pada Home Industry (Beppa Laiyya) di Desa Lamatti Riaja Kecamatan Bulupoddo
Authors: Harni Harni , Nurjannah Nurjannah
Published: November 2022

Strategi pemasaran adalah hal yang sangat krusial bagi perusahaan ataupun pelaku usaha yang menghasilkan produk, agar produk yang dihasilkan banyak diminati oleh konsumen maka pihak produsen harus pandai dalam menyikapi strategi pemasarannya. Salah satu strategi pemasaran yang dapat digunakan yaitu dengan labeling produk sebagai ciri khas produk tersebut, langkah awal yang dilakukan untuk meningkatkan pemasaran melalui labeling produk yakni adalah perencanaan dan persiapan selanjutnya yakni adalah mendesain label. Fenomena yang seringkali terjadi khususnya di pedesaan, masyarakat belum terlalu paham tentang pentingnya label sebuah produk sehingga tingkat pengetahuan konsumen terhadap usaha tersebut masih kurang salah satunya yakni pada home insdustry beppa laiya di Dusun Mangasa, Desa Lamatti Riaja, Kecamatan Bulupoddo. Home industry di Dusun Mangasa belum memiliki brand produk sendiri sehingga masih banyak konsumen yang belum mengetahui keberadaan home industry  tersebut. Kegiatan pendampingan peningkatan pemasaran yang dilakukan pada home industry beppa laiyya di Desa Lamatti Riaja Kecamatan Bulopoddo, mampu mengenalkan produk yang dihasilkan kepada masyarakat luas melalui label yang telah diadakan sebagai ciri khas produk. Dengan dikenalnya produk yang dihasilkan di masyarakat luas maka akan bertambah pula tingkat permintaan konsumen akan produk dari home industry tersebut.
Implementation of ERP in AKIP Evaluation System: A Case Study at The Ministry of Maritime Affairs And Fisheries
Authors: Wiryadinata Doni , Sediyono Eko , Widodo Aris Puji
Published: November 2022

Evaluasi kinerja pada instansi pemerintah merupakan aktivitas analisis yang sistematis, pemberian nilai, atribut, dan pengenalan permasalahan, serta mempersembahkan solusi atas masalah yang ditemukan guna meningkatkan akuntabilitas dan peningkatan kinerja instansi pemerintah. Untuk pemerintahan di Indonesia, penilaian atas akuntabilitas kinerja merupakan sebuah cerminan organisasi dalam merepresentasikan kinerjanya, sehingga tidak mengherankan jika setiap instansi pemerintah berupaya semaksimal mungkin untuk meningkatkan kinerjanya sesuai dengan kriteria yang ditetapkan oleh tim evaluator. Baru-baru ini, MENPAN RB merevisi evaluasi AKIP ke dalam Peraturan MENPAN RB Nomor 88 Tahun 2021 dengan banyak perubahan yang cukup fundamental. Hal ini berdampak pada perubahan strategi organisasi untuk mengembangkan evaluasi evaluasi guna dapat memprediksi nilai akuntabilitas kinerja dengan bantuan teknologi informasi berbasis ERP, seperti contoh kasus yang terjadi pada Kementerian Kelautan dan Perikanan. Penelitian ini merupakan studi kasus bertujuan untuk mengetahui bagaimana penerapan ERP pada pelaksanaan evaluasi AKIP yang dijalankan oleh Inspektorat Jenderal Kementerian Kelautan dan Perikanan mulai dari dukungan infrastruktur dan jaringan teknologi informasi yang digunakan, tahap perancangan dan pengembangan perangkat lunak, serta implementasinya dapat digunakan pada pelaksanaannya AKIP pada Tahun 2022. seperti contoh kasus yang terjadi pada Kementerian Kelautan dan Perikanan. Penelitian ini merupakan studi kasus bertujuan untuk mengetahui bagaimana penerapan ERP pada pelaksanaan evaluasi AKIP yang dijalankan oleh Inspektorat Jenderal Kementerian Kelautan dan Perikanan mulai dari dukungan infrastruktur dan jaringan teknologi informasi yang digunakan, tahap perancangan dan pengembangan perangkat lunak, serta implementasinya dapat digunakan pada pelaksanaannya AKIP pada Tahun 2022. seperti contoh kasus yang terjadi pada Kementerian Kelautan dan Perikanan. Penelitian ini merupakan studi kasus bertujuan untuk mengetahui bagaimana penerapan ERP pada pelaksanaan evaluasi AKIP yang dijalankan oleh Inspektorat Jenderal Kementerian Kelautan dan Perikanan mulai dari dukungan infrastruktur dan jaringan teknologi informasi yang digunakan, tahap perancangan dan pengembangan perangkat lunak, serta implementasinya dapat digunakan pada pelaksanaannya AKIP pada Tahun 2022.
Serious Game Design Of Sound Identification For Deaf Children Using The User Centered Design
Authors: Rina Fadmi , Abadi Anis Susila , Huda Sholeh
Published: November 2022

The loss of hearing function in deaf children causes deaf children to experience obstacles in listening to the sound of objects or sounds of language as children generally hear. Therefore, it is necessary to optimize the hearing function of deaf children. The Development of Sound and Rhythm Perception Communication (PKPBI) is a special program to practice understanding sound so that the remaining hearing of deaf children can be maximized. So far, the PKPBI learning media at the sound identification stage used by the Karnna Manohara Yogyakarta Special School teacher is the keyboard. However, the keyboard has weaknesses such as the collection of sounds on the keyboard is very limited. Another problem is the Covid 19 pandemic, PKPBI learning is less than optimal due to limited face-to-face meetings. The purpose of this research is to design a serious game as a learning medium for sound identification for deaf children that can be used in the classroom and at home. The method used to design serious sound identification games is User Centered Design (UCD). Based on the research results, the design of this serious game can be developed into a serious game application to practice sound identification in deaf children.
Evolutionary theory and feminism
Authors: Załuski Wojciech
Published: November 2022

It is often argued that evolutionary theory and feminism remain in tension, since the evolutionary view of human nature is hard to reconcile with the feminist view. The goal of this paper is to demonstrate that this thesis is false. This goal is realized by reconstructing a certain anti-feminist evolutionary argument (whose descriptive conclusion is the “patriarchal” picture of male and female nature, and the normative conclusion is the claim that given the deep differences between men and women the feminist postulates cannot be achieved) and providing its critique. The argument is based on three premises: a theory of parental investment, the assumption of a relatively large (compared with other species) men’s parental investment in ancestral environments, and the uncertainty of paternity. Its (descriptive) conclusion is the claim that men are “by nature” much more polygamously disposed, much more desirous of power (over the opposite sex), and much more aggressive than women. The paper presents several objections to this argument. The first objection questions its internal coherence. The second one points at its counterintuitive (not supported by empirical facts) consequences. The third one criticizes one of the assumptions of the argument, i.e. the assumption about a relatively large (compared with other species) men’s parental investment in ancestral environments.