bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental Health Problems in Health-Care Workers of Tertiary Level COVID-19 Care Centers in Central India
Authors: Mahajan Sudhir Laludeo , Saraf Anantprakash Siddharthkumar , Sathe Harshal Shriram , Mishra Kshirod Kumar , John Sally , Reshamvala Ahmed Mushtaq
Published: April 2023

Background:

The health-care workers (HCWs) who are overburdened during the COVID-19 pandemic are at increased risk of developing psychological disorders.

Aim:

The aim of this study was to assess the magnitude of psychological problems such as depression, anxiety, and fear of COVID-19 among the HCWs and to study their correlates. Material and Methods: The study is an online multicentric cross-sectional survey of mental health problems in the HCWs of three tertiary level COVID care centers in Central India. HCWs were assessed using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale-7 (GAD-7), and Fear of COVID-19 Scale.

Results:

Out of 467 HCWs assessed, 25.5% of the participants had depression (defined by PHQ-9 score of more than 5), whereas anxiety was present in 24.4% of the study subjects (defined by GAD-7 score of more than 5). Forty-six percent of the participants had medium-to-high levels of fear of COVID-19. Female gender, working in the nonclinical department, direct involvement in care of COVID-19 patients, perceived worsening of physical health status following the pandemic outbreak, and past history of psychiatric problem were the factors significantly associated with presence of depression as well as anxiety. Age of the participant had a positive correlation with fear of COVID-19 and a negative correlation with depression and anxiety levels.

Conclusion:

HCWs serving in COVID hospitals are vulnerable to develop mental health problems and appropriate screening measures and interventions should be designed so as to preserve mental health of this vital task force.
Noninvasive Brain Stimulation for Cognitive Impairment in Schizophrenia
Authors: Kar Sujita Kumar , Singh Amit
Published: April 2023

Schizophrenia is a chronic illness that causes significant impairment in various areas of life. Patients with schizophrenia typically develop symptoms in their second to third decades of life and have a waxing-waning course. The combination of genetics and the environment is essential in developing schizophrenia. Despite proper treatment trials, many patients remain sick and dysfunctional. In patients with schizophrenia, cognitive impairment is a prevalent symptom. Patients frequently display a variety of cognitive abnormalities, including those affecting verbal fluency, executive function, working memory, attention, focus, visuospatial skills, and social cognition. Neuroplasticity is impaired in schizophrenia, and cognitive remediation procedures have improved neuroplasticity. Evidence suggests that cognitive remediation procedures can help patients with schizophrenia address their cognitive difficulties. This review attempts to evaluate the scope of various noninvasive brain stimulation to treat cognitive impairment in schizophrenia.
A Rare Case of Kartagener's Syndrome with Schizophrenia
Authors: Khar Prerna Balkrishen , Das Nishant , Roy Parijat , Bhatankar Swaroop
Published: April 2023

Kartagener's syndrome is a rare genetic disorder of primary ciliary dyskinesia characterized by the triad of bronchiectasis, sinusitis, and situs inversus. There is limited data on the role of Kartagener's syndrome leading to psychotic manifestations. We would like to discuss the case of a 26-year-old male, who presented to us with psychotic symptoms of 4-year duration. Upon detailed physical examination and pertinent investigations, he was diagnosed to be having Kartagener's syndrome. He was treated with antipsychotics and benzodiazepines. This case highlights the importance of a thorough physical examination and eliciting medical history, as it may lead to the finding of various syndromes that have been said to be associated with schizophrenia, thereby contributing to its genetic hypothesis. The neurological, biochemical, and structural malformations seen in Kartagener's syndrome may also lead to psychotic manifestations. They could be genetically linked to loci contributing to an increased risk of psychosis.
An Exploratory Survey on the Knowledge, Attitudes, and Perceptions toward TikTok
Authors: Shah Bhumika , Karia Sagar , Mandalia Bilvesh , Shah Nilesh , Sousa Avinash De
Published: April 2023

Background:

TikTok is a mobile application that had become very popular among youth in college and adults alike. Many people have used TikTok as an alternate form of social media and share videos from there on different social media platforms. This study was aimed as survey to ascertain the knowledge, attitudes, and practices toward TikTok as an application.

Methodology:

A semi-structured questionnaire was prepared to consist of questions regarding demographic details, knowledge regarding TikTok, frequency of usage of TikTok, attitudes toward its use and suggestions for change required in it. The questionnaire was circulated among students through e-mails and Whatsapp. The form was distributed three times in all within a gap of 7 days. The data collected were subjected to descriptive statistical analysis and percentages.

Results:

Seven hundred students in all were mailed and received the questionnaire. We received 583 responses, of which 81 responses being incomplete were removed, and the final analysis was done with 502 responses. Three hundred and three (60.4%) participants felt that it could be used for entertainment and only 11 (2.2%) mentioned education or awareness. Two hundred and seventy-two (54.2%) participants felt that TikTok use could be a media for boosting self-esteem and self-image.

Conclusion:

Further studies in detail about various facets of TikTok need to be studied in diverse population to generalize our findings and know how this application has influenced the youth in various sectors.
Depression Anxiety and Stress in Patients Visiting Medicine Outpatient Department of Tertiary Care Hospital During COVID Pandemic
Authors: Zain  , Datar Manjiri Chaitanya , Shetty Jyoti Vittaldas
Published: April 2023

Background:

Coronavirus disease 2019 is a unique pandemic that has struck all the nations. Extraordinary crisis warrants extraordinary response like severe lockdown. The study aims to assess the prevalence of depression, anxiety, and stress, in general, and around corona, in particular, in people with medical comorbidity.

Setting and Design:

This is a cross-sectional study that was carried out in outpatient department setting of a tertiary care hospital from July 2020 to September 2020.

Aims and Objectives:

The study aimed to assess the prevalence of depression, anxiety, and stress, in general, and anxiety around corona, in particular, and the correlation with sociodemographic profile and comorbid medical illness.

Materials and Methods:

Fifty patients with various medical comorbidities were assessed using depression anxiety and stress scale and corona anxiety scale (CAS) and a specially designed pro forma.

Statistical Analysis:

The collected data were coded and entered in Microsoft Excel sheet. The data were analyzed using Statistical Packages for the Social Sciences version 20.0 software. The results are presented in a tabular and graphical format. For quantitative data, mean, standard deviation, median, etc., were calculated. For qualitative data, various frequency, rates, ratio, and percentage were calculated.

Results:

A statistically significant relationship was found between education and anxiety (P = 0.027) and between medical comorbidity and depression.

Conclusion:

In our study, medical comorbidities are associated with depressive cognition. Surprisingly, no significant anxiety on CAS could be found.
Diagnostic and prognostic value of circulating tumor cells in Indian women with suspected ovarian cancer
Authors: Singh Swarnima , Kumar Uday
Published: April 2023

Background:

“Liquid biopsy,” where body fluids are screened for biomarkers, is gathering substantial research. We aimed to examine women with suspected ovarian cancer for the presence of circulating tumor cells (CTCs) and study its role in prediction of chemoresistance and survival.

Methods:

Magnetic powder labeled monoclonal antibodies for epithelial cell adhesion molecule (EpCAM), mucin 1 cell surface associated, mucin 16 cell surface associated, or carbohydrate antigen 125 (CA125), were prepared according to the manufacturer’s protocol. Expression of three ovarian cancer related genes was detected in CTCs using multiplex reverse transcriptase-polymerase chain reaction. CTCs and serum CA125 were measured in 100 patients with suspected ovarian cancer. Correlations with clinicopathological parameters and treatment were analyzed.

Results:

CTCs were detected in 18/70 (25.7%) of women with malignancy compared to 0/30 (0.0%) in those with benign gynecologic diseases (P = 0.001). The sensitivity and specificity of the CTC test for predicting a malignant histology in pelvic masses were 27.7% (95% CI: 16.3%, 37.7%) and 100% (95% CI: 85.8%, 100%), respectively. The number of CTCs correlated with stage of ovarian cancer (P = 0.030). The presence of EpCAM + CTC at primary diagnosis in ovarian cancer was found to be an independent predictor of a poor progression free survival (HR, 3.3; 95% CI, 1.3–8.4; P = 0.010), overall survival (HR, 2.6; 95% CI,1.1–5.6; P = 0.019), and resistance to chemotherapy (OR 8.6; 95% CI, 1.8–43.7; P = 0.009).

Conclusion:

Expression of EpCAM + CTC in ovarian cancer predicts platinum resistance and poor prognosis. This information could be further used in investigating anti-EpCAM-targeted therapies in ovarian cancer.
Treatment options in primary mediastinal B cell lymphoma patients, retrospective multicentric analysis; a Turkısh oncology group study
Authors: Acar Ramazan , Paydaş Semra , Yıldırım Murat , Kılıçarslan Emrah , Sahın Ugur , Dogan Ali , Guven Deniz C. , Ekıncı Omer , Tıglıoglu Mesut , Erdogan Isıl , Elıbol Tayfun , Kızıloz Halil , Aykan Musa B. , Sayın Selim , Kaptan Kursat , Soydan Ender , Gokmen Ayla , Esen Ramazan , Barısta Ibrahim , Albayrak Murat , Erturk Ismail , Yıldız Birol , Keskın Gulsema Y. , Aylı Meltem , Karadurmus Nuri
Published: April 2023

Introduction and Aim:

Primary mediastinal B-cell lymphomas (PMBL) are aggressive B- cell lymphomas. Although the initial treatment models vary in PMBL, appropriate treatment methods are not known. We aim to show real-life data on health outcomes in adult patients with PMBL who received various type of chemoimmunotherapies in Turkey.

Method:

We analyzed the data of 61 patients who received treatments for PMBL from 2010 to 2020. The overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated.

Results:

61 patients were observed in this study. The mean age of the study group was 38.4 ± 13.5 years. From among them, 49.2% of the patients were female (n = 30). For first-line therapy, 33 of them had received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen (54%). Twenty-five patients had received rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH-R) regimen. The ORR was 77%. The median OS and PFS were as follows: 25 months (95% CI: 20.4–29.4) and 13 months (95% CI: 8.6–17.3), respectively. The OS and PFS at 12 months were 91.3% and 50%, respectively. The OS and PFS at five years were 64.9% and 36.7%, respectively. Median follow-up time period was 20 months (IQR 8.5–38.5).

Conclusion:

R-CHOP and DA-EPOCH-R showed good results in PMBL. These remain one of the best determined systemic treatment options for first-line therapy. Also, the treatment was associated with good efficacy and tolerability.
To study the pattern of seroconversion for SARS-CoV-2 IgG antibodies in COVID-infected cancer patients and to correlate it clinically – A cross-sectional study
Authors: Gupta Surabhi , Chauhan Nitu , Kumari Pratibha , Bansal Manish , Chahar Ajeet
Published: April 2023

Background:

Though as per literature cancer is also consider an associated risk factor for morbidity and mortality for covid infection but practically most of the cancer patients showed no symptoms with less mortality in second wave of pandemic. So this cross sectional comparative analysis study was designed to see the prevalence of sero-conversion for SARS –coV for IgG in covid infected cancer patients and to compare the IgG antibodies level between covid infected cancer patients and covid infected healthy persons.

Material and Method:

Covid-19 antibody screening of covid recovered cancer patients as well as covid recovered healthy persons was done in department of Transfusion Medicine.IgG antibody for COVID-19 was detected using microtiter plate with whole-cell antigen coating, an in-house validated kit by NIV ICMR3. Prevalence of sero-conversion was noted down in both the groups and compared.

Result:

There was more infectivity rate in second covid wave. Case fatality rate was much lesser as compared to 1st wave in cancer patients. In cancer patients maximum seroconversion was seen in younger group i.e. 21-30 yrs. of age, this was in contrast to finding in general population, where minimum seroconversion was seen in younger age group. It was observed that more prevalence of sero conversion was seen in general population as compared to cancer patients, but difference was non-significant.

Conclusion:

Though cancer patients showed less rate of seroconversion as compared to normal healthy person, but none of them showed any moderate or severe symptoms inspite of being a risk factor for severity of covid. Though larger study are required to comment on statistical conclusion.
An immunohistochemical evaluation of tumor-associated macrophages (M1 and M2) in carcinoma prostate – An institutional study
Authors: Hadimani Soumya M. , Das Subhashish , Harish K. G
Published: April 2023

Background:

Tumor-associated macrophages (TAM) are the main component of inflammation along with leukocytes, endothelial cells and fibroblasts together form a tumor microenvironment, with immune cells representing its vital component. Many studies suggested that TAMs cumulating in tumors correlate with a poor prognosis. In prostate cancer, TAMs can increase cancer cell invasion by stimulating tumor angiogenesis, degrading the extracellular matrix, and also suppresses the antitumor functions of cytotoxic T cells resulting in poor prognosis.

Aims and Objectives:

1. To determine the expression of M1 (CD68) and M2 (CD163) in prostate carcinoma (Pca). 2. To find the association between M1, M2 macrophage with Gleason’s score and stage of Pca.

Materials and Methods:

This is a retrospective observational study. All transurethral resection prostatic (TURP) chips positive for Pca and the clinical details were collected. Radiologic findings with respect to stage of disease, size of lesion, were noted.

Results:

Among the 62 cases studied, majority of the cases were in-between the age of 61–70 years. Highest cases were seen in Gleason’s score 8, 9, and 10 (62%), prostatic specific antigen (PSA) levels 20–80 ng/mL (64%), tumor size 3–6 cm (51.6%), T3 stage (40.3%), N1 lymph node stage (70.9%). M1 stage of (31%). CD68 and CD163 expression was analyzed with Gleason’s score, TNM stage and PSA levels. CD68 score 3 correlated with low distant and nodal metastasis 6.2% and 6.8%, respectively. CD163 score 3 correlated with high metastasis to lymph nodes and distant metastasis of 86.3% and 25%, respectively. On further analysis, statistically convincing association between the CD163 expression and Gleason’s score, PSA levels, nodal and distant metastasis was found.

Conclusion:

CD68 expression was correlated with good prognosis with less nodal and distant metastasis and Cd163 expression has poor outcome with increased chances of nodal and distant metastasis. Further exploration of TAM mechanisms and immune checkpoints in the prostate tumor microenvironment can furnish new light and motives for the treatment of Pca.
An immunohistochemical study of double-expressor lymphomas and its correlation with cell of origin
Authors: Ananthamurthy Anuradha
Published: April 2023

Background:

Diffuse large B cell Lymphomas (DLBCL) that co express C MYC and BCL 2 are known as ‘double expressor lymphomas’ and are believed to have a worse prognosis than other diffuse large B cell lymphomas. This was a study to assess the frequency of double expressor lymphomas in our cohort of DLBCL

Aims and Objectives:

The aims of this study were to assess the frequency of double expression of C MYC and BCL 2 in cases of DLBCL and to correlate the same with clinicopathological parameters including cell of origin, namely germinal centre type versus non germinal centre type.

Materials and Methods:

This was a retrospective observational study Immunostaining for MYC antibody and BCL2 were performed using the standard polymer/DAB technique. 40% for MYC and 50% for BCL2 were taken as cut off values.Chi square analysis was used to compare the variables, and a p value of less than 0.05 was taken as statistically significant

Results:

Of 40 cases studied, 11 (27.5%) were double expressors. There was no significant correlation of double expression with gender, site (nodal versus extra nodal), cell of origin namely germinal centre/non germinal centre types and Ki67 index when compared to the other group which did not show double expression

Conclusions:

Immunohistochemistry is a useful technique to detect double expressor lymphomas which are known to have an aggressive course. Cell of origin did not show significant correlation with double expression in our study.
Prognostic relevance of pre-treatment inflammatory biomarkers along with other clinicopathological and treatment factors in oral cavity cancers
Authors: Kothandaraman Shri Kamakshi , Krishnamurthy Arvind , Mittal Saket , Ramshankar Vijayalakshmi
Published: April 2023

Background:

Inflammation has traditionally been considered to be one of the hallmarks of cancer, and systemic inflammatory responses have a prognostic value in many solid cancers. The use of inflammation-based prognostic markers along with traditional clinicopathological prognostic markers in oral cavity cancers has not been studied well.

Materials and Methods:

This is a retrospective study from a prospectively maintained database of patients with oral cancers who were managed in a regional cancer center in south India. The study included patients with squamous cell carcinoma of the oral cavity who were treated with curative intent from January to December 2016.

Results and Discussion:

Three hundred sixty-one patients met the eligibility criteria and were included in the study. The median age of our patient cohort was 45 years; the male-to-female ratio was 3.7:1. All of the patients underwent curative treatments after a multi-disciplinary board concurrence. Advanced T stage, patients with buccal mucosal cancers and patients who received upfront non-surgical treatments have poorer survival outcomes. The clinicopathological variables that predicted a poorer overall survival in the cohort of patients treated with upfront surgery were advanced T Stage, higher grade, presence of perineural invasion, a higher inflammatory maker, and combination of platelet and neutrophil lymphocyte ratio (COP-NLR).

Conclusion:

Our unique study of oral cavity cancer patients with a primary aim of exploring the prognostic significance of the pre-treatment inflammatory markers gave very interesting results. The prognostic significance of COP-NLR and other inflammatory markers in oral cancers need to be further explored. More importantly, our study has clearly reiterated that meaningful long-term survival outcomes in oral cavity cancers can only be achieved with the incorporation of upfront surgery.
Alteration in key oncoprotein expression in gastric adenocarcinoma – An immunohistochemical study
Authors: Jain Pragya , Wadhwa Neelam , Diwaker Preeti , Joshi Mohit Kumar , Mishra Kiran
Published: April 2023

Objective:

This study was conducted to evaluate the frequency and clinicopathologic correlates of human epidermal growth factor receptor 2 (HER-2)/neu and betacatenin (BC) oncoproteins in gastric adenocarcinoma and to seek correlation if any between their expression status.

Materials and Methods:

This cross-sectional analytical immunohistochemistry (IHC) study was performed on 50 cases of gastric adenocarcinoma. HER-2/neu immunoexpression was scored as per criteria by Ruschoff et al. as positive (3+), equivocal (2+), and negative (1+, 0). Aberrant BC expression was categorized as nuclear, cytoplasmic, and reduced membranous immunoexpression. Protein expression results of both oncoproteins were correlated with conventional clinicopathological parameters. Correlation between immunoexpression profiles of both proteins was also analyzed. P <0.05 was considered statistically significant.

Results:

HER-2/neu positivity (2 + and 3+) was seen in 94% of the cases; almost 60% had strong (3+) expression. All cases showed aberrant BC immunoexpression (any pattern) except 2 cases that revealed negative expression (a form of aberrant immunoexpression) and were removed from analysis due to a very small number. The pattern of BC expression was as follows: nuclear expression (38%), cytoplasmic expression (82%), reduced membranous expression (96%), no staining (4%) cases. HER-2/neu expression correlated with age. No significant correlation was found between any of the 2 oncoprotein immunoexpression and other clinicopathological parameters (P > 0.05). Concordance between protein expression of HER-2/neu and BC was seen in >93% cases, however, the correlation was not significant.

Conclusion:

HER-2/neu and BC oncoprotein expression are frequently dysregulated in gastric adenocarcinomas. The significance of pathways involving HER-2/neu and BC in gastric carcinogenesis should be explored.
Early endometrial carcinoma: Experience and outcomes
Authors: Goel Priyanka , Singh Vikram , Sharma Rakesh , Chaudhary Debashish , Chatterjee Abhishek , Dora Tapas , Sancheti Sankalp , Goel Alok , Khandelwal Sachin , Sali Akash Pramod , Kaur Harpreet , Guru Arvind , Kapoor Rakesh
Published: April 2023

Aim:

Endometrial carcinoma (EC) data from India are very sparse. We did a retrospective analysis of our patients registered at this peripheral cancer center based in rural Punjab and studied their outcome.

Materials and Methods:

Ninety-eight Stage I and II EC patients with endometroid histology registered at our institute from January 2015 to April 2020 were studied for demography, histopathology, treatment received, and outcomes. FIGO 2009 staging and new European Society for Medical Oncology (ESMO) risk group classification was used.

Results:

Our patients had a median age of 60 years (range 32–93 years). There were 39 (39.8%), 41 (42.0%), 4 (4.1%), 12 (12.2%) patients in the low risk, intermediate risk (IR), high intermediate risk, and high risk groups, respectively, as per new ESMO risk classification. Two (2.0%) patients had incomplete information to assign them to a particular risk group. Fifty (46.7%) patients underwent complete surgical staging and 54 (50.5%) patients received adjuvant RT. With a median follow-up of 27.0 months, there were 1 locoregional and 2 distant recurrences. There were 8 deaths in total. Three-year overall survival for the entire group is 90.6%.

Conclusions:

The risk group determines adjuvant treatment in endometrial cancer. Patients operated at dedicated cancer center tend to have better surgical staging and thus better outcome because of better risk stratification and grouping for adjuvant therapy. IR histology was more common in our group of patients, which is variable as compared to available literature.
Refractory lower gastrointestinal bleeding in a patient with parkes weber syndrome
Authors: Abeles Elisabeth Belman , Done Joy Zhou , Atallah Chady
Published: April 2023

Parkes Weber syndrome (PWS) is a rare disorder of limb hypertrophy and vascular abnormalities, including arteriovenous malformations (AVMs). To the best of our knowledge, this is the first case of a refractory lower gastrointestinal bleeding due to AVMs in a patient with PWS. We describe the case of a 54-year-old woman with PWS who presented with refractory lower gastrointestinal bleeding due to extensive AVMs in the sigmoid colon and rectum. We review her colonoscopy and computed tomography imaging and ultimate surgical management, including a low anterior resection and diverting loop ileostomy. In rare cases, PWS can cause severe lower gastrointestinal bleeding. It is imperative to understand the role of surgical intervention in such cases of refractory lower gastrointestinal bleeding.
Campylobacter jejuni causes colorectal cancer
Authors: Gervaz Pascal Alain , De Campos Álvaro , Caeiro Alberto
Published: April 2023

The incidence of colorectal cancer (CRC) has drastically increased in several Asian countries during the past four decades. These rapid epidemiological variations suggest that environmental parameters contribute to neoplastic transformation within the intestinal epithelium. A Western type of diet (rich in animal fat and proteins) is a recognized risk factor. In addition, there is a strong link between the type of diet and composition of the microbiota. These findings suggest that some bacteria may contribute to neoplastic transformation in the colon and rectum. However, a causal relationship between a specific microorganism and the development of CRC remains elusive. In this paper, we recapitulate the clinical evidence, suggesting that epigenetic transformation mediated by commensal bacteria is a prerequisite for tumor development in the large bowel. We review the experimental evidence, suggesting that a type of Campylobacter is likely to be involved in this neoplastic process. Campylobacter is highly prevalent in modern cattle and poultry farms and has the capacity to adhere to the colonic epithelium and contribute to genomic instability by releasing DNA-damaging toxins. Therefore, we hypothesize that the Campylobacter/Helicobacter group of bacteria may play a role in development of the two most common neoplasia of the digestive tract, i.e. adenocarcinoma of the colon and stomach, respectively.
El director de arte publicitario. 80 años después de su nacimiento
Authors: Roca David
Published: April 2023

En los años 20 aparece en la agencia de publicidad una nueva figura: el director de arte. Desde entonces hasta ahora, este profesional ha sufrido una constante evolución, que se rompe a partir de mediados de los '80 con la entrada de la autoedición en la agencia de publicidad. A partir de ese momento, el director de arte empieza a adquirir una creciente importancia en la profesión.

Este trabajo consiste en explicar cómo es esa "nueva" figura, en qué consiste su trabajo en la actualidad y cómo han cambiado las estructuras productivas desde que adquiere "poder" en el proceso creativo. El artículo se basa en un estudio cualitativo, que consistió en entrevistas personales a directores de arte de diferentes agencias de publicidad de Barcelona. La causa de llevar a cabo este estudio es la escasa biografía acerca de este tema.
Pleading competition damages claims and defences: recent guidance from the Court of Appeal and the Competition Appeal Tribunal
Authors: Hughes Mat , Whiteford Elaine
Published: April 2023

The Court of Appeal and the Competition Appeal Tribunal have recently handed down guidance in NTN v. Stellantis and O’Higgins and Evans, as to the requirements that must be satisfied to plead a competition law claim or defence, whether the claim is an individual claim or a collective action. This article considers the economic and legal issues that need to be addressed in pleadings, in the light of that guidance. Both judgments make clear that economists must be consulted at the very earliest stage to ensure that the pleadings, whether a claim or defence, or in an individual claim or a collective action, reflect clearly the economic theories relied upon and do so by reference to underlying facts. If a pleading does not comply with this guidance, it risks being struck out.
Intel round 2: starting from square one
Authors: Nilausen Lau , Sangha Rameet
Published: April 2023

This article explains how the General Court’s January 2022 Intel judgment raises the bar for assessments of as-efficient competitor (AEC) tests, with reference to six specific aspects of the European Commission’s (the Commission’s) analysis.
Main developments in State aid control 2021–2022
Authors: Badia Josep M. Carpi , Georgiopoulos Ilias
Published: April 2023

The last two years of State aid policy and enforcement have been marked by two unprecedented back-to-back crises, namely the COVID-19 pandemic and Russia’s aggression against Ukraine. The Commission acted swiftly to mitigate their effects, by establishing specific sets of rules setting out the criteria for its assessment of national support measures. That enabled Member States to rely on the flexibility of State aid rules to weather those crises. On that basis, the Commission developed a rich and prolific decisional practice. During this period, the Commission also accelerated the review of several State aid guidelines as well as of the General Block Exemption Regulation, with a view to ensuring that those instruments are fit-for-purpose and aligned with its Green Deal and Digital Strategy objectives. That alignment is also evidenced in several Commission decisions. This article also discusses the main judicial developments in 2021–2022, notably on COVID-19-related measures in the area of aviation, on State aid and taxation and on a number of procedural and substantive issues.
Pomiędzy Starym a Nowym Światem. Historia, migracje, etniczność
Authors: Kijewska-Trembecka Marta , Michna Ewa
Published: April 2023

Profesor Adam Walaszek to badacz doceniany w Polsce i świecie, cytowany i nagradzany, klasyk polskich studiów migracyjnych i etnicznych. Wybitny znawca dziejów migracji Europejczyków i przemian diaspory polskiej w Ameryce Północnej. Od zawsze związany z Krakowem, gdzie się urodził i gdzie nieprzerwanie mieszka, a zawodowo z Alma Mater Jagellonica. Współpracuje z renomowanymi ośrodkami badawczymi w wielu krajach. Jest beneficjentem licznych stypendiów naukowych w europejskich, północnoamerykańskich i australijskich uniwersytetach, należy do szeregu rad stowarzyszeń naukowych i redakcji czasopism w kraju i za granicą. Tom dedykowany Profesorowi Walaszkowi ma różnorodny i interdyscyplinarny charakter, tak jak heterogeniczne jest grono jego uczniów, przyjaciół i współpracowników z Instytutu Badań Polonijnych i Instytutu Amerykanistyki i Studiów Polonijnych, z którymi Profesor był związany niemal od początku swojej kariery akademickiej. Autorzy i autorki artykułów reprezentują różne dyscypliny – najbliższą Profesorowi Walaszkowi historię, ale też socjologię, kulturoznawstwo oraz politologię. Tytuł książki nawiązuje do zainteresowań naukowych i pól badawczych eksplorowanych przez Adama Walaszka. Zebrane w tomie teksty poświęcone są różnorodnym zjawiskom oraz procesom zachodzącym w Starym i Nowym Świecie, które zostały podzielone na trzy części, odpowiadające zainteresowaniom naukowym Profesora. W pierwszej znalazły się artykuły na temat historii i polityki, w drugiej dotyczące problematyki migracji oraz Polonii i Polaków w świecie; książkę zamykają teksty na temat starej i nowej etniczności.
Johannes Kepler, Galileo Galilei, Robert Fludd, Giordano Bruno and Nicolaus Copernicus: in absentia arguments on ‘happy Earths’ and the infinity of the cosmos
Authors: Kuzmin A. V.
Published: April 2023

The ideas within Nicolaus Copernicus’ De Revolutionibus Orbium Coelestium (1543) and Giordano Bruno’s De l’infinito, universo e mondi (1584) created a new heliocentric image of the universe.1 The concept of an infinite space without limits was beginning to appear in astronomy. Bruno was the first to break Aristotle’s sphere, producing a mass of arguments disclaiming its presence and verifying infinite space. Johannes Kepler was more careful in his treatment of the model of an infinite cosmos, mainly because of the contradictions in his own theory as expressed in his Mysterium cosmographicum (Prodromus dissertationum cosmographicarum, continens Mysterium cosmographicum de admirabili proportione orbium coelestium: deque causis coelorum numeri, magnitudinisy motuumque periodiconim genuinis et propriis, demonstratum per quinque regularia corpora Geometrica) (1596). Galileo Galilei, on the other hand, supported the idea of an infinite cosmos, describing ways in which to prove it, although it could not be verified because of a lack of adequate telescope observations. At the same time, Robert Fludd developed a radically different concept of the stages of creation, synthesising earlier ancient cosmological ideas and the biblical world outlook, and thus anticipating cosmological models of the first half of the twentieth century.
Carl Otto Czeschka: Ein Wiener Künstler in Hamburg
Authors: Spielmann Heinz , Häussler Hella , Joppien Rüdiger
Published: April 2023

Briefe an den 1907 nach Hamburg berufenen Carl Otto Czeschka von seinen Wiener Freunden dokumentieren anschaulich das Leben und die Gesellschaft Wiens nach 1900. »Verlangst Du wirklich, dass wir Dir jedes Mal schreiben, wie uns Deine Sachen gefallen? Ist Dir das nicht schon zu langweilig zu hören? Du bist ein- für allemal für uns eine ganz alleinstehende Qualität, Du machst heute Sachen, wie sie überhaupt noch nie gemacht worden sind, und man geniert sich ja förmlich, über solche Kunstwerke dummes Lob zu schreiben. Jeder kleinste Schmarren, den Du schickst, ist ein Fest für uns.« (Fritz Wärndorfer an C. O. Czeschka am 30. Dezember 1909) Der aus Wien stammende Carl Otto Czeschka war seit 1905 einer der wichtigen Entwerfer für die Wiener Werkstätte. Als junger Lehrer an der Kunstgewerbeschule Wien war er Entdecker und Förderer von Oskar Kokoschka. Czeschkas Berufung 1907 nach Hamburg markierte einen Wendepunkt in der künstlerischen Bedeutung der Hamburger Kunstgewerbeschule. Neben seiner Lehrtätigkeit dort bis 1943 erhielt Czeschka zahlreiche Aufträge als Designer und Gebrauchsgrafiker. Ausführungen zu zwei bisher wenig bekannten Werken Czeschkas, den Glaskunstfenstern für die Gewerbekammer und den Dekansketten für die 1919 gegründete Hamburgische Universität, runden die Briefedition ab.
Max Emden: Hamburger Kaufmann, Kaufhauserfinder, Ästhet und Mäzen
Authors: Brömmling Ulrich
Published: April 2023

Der schöngeistige, eigensinnige Wohltäter und das Schicksal seiner Kunstsammlung: Biographie und Film bieten eindrückliche Einsichten in Emdens Leben. Inklusive der Film-DVD »Auch Leben ist eine Kunst - Der Fall Max Emden« (2019). Immer bunter wurde in den Köpfen der Nachwelt das Leben, das Max Emden mit allerlei leicht bekleideten Mädchen auf den Brissago-Inseln geführt haben soll. Yachten, Segelboote, Skiurlaube - allen Luxus brachte man mit dem Hamburger Kaufmann in Verbindung. War das die ganze Wahrheit? Ulrich Brömmling hat sich auf Spurensuche begeben und präsentiert in seiner neuen Biographie einen ganz anderen Max Emden. Das Netz seiner Kaufhäuser, darunter das Berliner KaDeWe, das Münchner Oberpollinger, das Allas in Stockholm oder das Corvín in Budapest, überzog ganz Europa. Neben seiner Leidenschaft fürs Geschäft war Emden ein Freund der Künste, der Architektur, des Sports und ein Wohltäter Hamburgs. 1927 kaufte er die Brissago-Inseln im Lago Maggiore und zog ein Jahr später ins Tessin - weg vom »Schmutz, den die Industrialisierung gebracht hatte«. Von dort musste er bald miterleben, wie die Machthaber in Berlin ihn um sein Vermögen brachten. Ein Schicksal, dem auch seine Kunstsammlung zum Opfer fiel, die er deutlich unter Wert verkaufen musste - darunter Canalettos, die über Zwischenhändler an Adolf Hitler persönlich gingen. Wirtschaftlich ruiniert starb Max Emden 65-jährig im Juni 1940. Max Emden (1874-1940) entstammte einer der ältesten jüdischen Kaufmannsfamilien Hamburgs. Beim Eintritt ins väterliche Geschäft 1904 bestand M. J. Emden Söhne schon seit 80 Jahren. Aber erst Max Emden machte die Firma groß.
Troplowitz: Porträt eines Unternehmerpaares
Authors: Albrecht Henning
Published: April 2023

Unternehmerisches Genie, Philanthrop, Politiker und Mäzen - das beeindruckende Wirken und Engagement Oscar Troplowitz` und seiner Frau Gertrud. Das Erfolgsgeheimnis von Oscar Troplowitz war seine außergewöhnliche Mehrfachbegabung: Er vereinte wissenschaftliche Neugier, kaufmännisches Können und Menschenfreundlichkeit mit einem Sinn für die Chancen der industriellen Welt. Aus einem Labor im Untergeschoss eines Wohnhauses schuf er einen pharmazeutisch-kosmetischen Industriebetrieb von globaler Bedeutung: Beiersdorf & Co. Er fand innovative Antworten auf medizinische Fragen und entwickelte kosmetische Angebote für eine neue Ära, in der Körperpflege zum Massenphänomen wurde. Vor allem aber kreierte er Weltmarken, die bis heute jeder kennt und die Synonyme für die jeweiligen »Gegenstände« geworden sind: Labello, Tesa, Nivea oder Leukoplast. Henning Albrecht erzählt den Aufbruch in die Markenwelt des 20. Jahrhunderts und die Entstehung der Beiersdorf AG von den handelnden Personen her - zwei engagierten Bürgern, leidenschaftlichen Kunstsammlern und großzügigen Mäzenen. 100 Jahre nach der bedeutenden Großstiftung Gertrud Troplowitz` an die Kunsthalle Hamburg erscheint mit dieser neuen Biographie des Unternehmerpaares ein spannendes Stück deutscher Wirtschafts- und Kulturgeschichte. Oscar (1863-1918) und Gertrud (1869-1920) Troplowitz 1890 erwarb Oscar Troplowitz das pharmazeutische Labor von Paul Beiersdorf in Altona, das er bis zum Ersten Weltkrieg zu einem weltweit aktiven und hochprofitablen Unternehmen aufbaute: zur späteren Beiersdorf AG, Hersteller von Marken wie Nivea, Leukoplast und tesa. Mit seiner Frau Gertrud trug er ab 1909 eine der bedeutendsten Hamburger Kunstsammlungen in einer prachtvollen Villa an der Außenalster zusammen. Nachdem der Philanthrop Oscar Troplowitz verstorben war, fiel Gertrud - bis zu ihrem eigenen Tod nur zwei Jahre später - die Rolle als herausragende Mäzenin zu.
Design and Development of Robot Base Crack Detection System for Railway Track
Authors: Gulhane S.V. , Deshmukh Kartik , Wakudkar Praful , Sawarkar Pawan , Shivankar Pranay , Tajane Rahul
Published: April 2023

Rail transportation in India is at the forefront of providing the necessary transportation infrastructure to satisfy the demands of a quickly expanding economy. India currently has the fourth-largest rail network in the entire world. Yet, we have not met international standards in terms of dependability and safety in railway sector. The biggest challenge in conducting a railway analysis is identifying structural flaws. They risk straying and losing their intended course if not properly managed. The proposed device is appropriate for rail transportation since it allows for the early detection and prevention of accidents. This will be installed on the train engine for the user to use the crash sensor. As a result, if a specific crack is discovered on the trail, the train automatically slows down and stops somewhere, and the exact location of the crack is communicated to the control room. Second, the subsequent cause of accidents is avoided by using identical sensors installed on the engine of two vehicles travelling down the same road. The sensor detects the same signal from a different vehicle and automatically applies the brakes and stops the vehicle at a specific distance. Train diversions might take advantage of several losses from train accidents.
LANGUAGE, LITERATURE, PROCESS 2023 - BOOK OF ABSTRACTS
Authors: Autora Grupa
Published: April 2023

Since early 2020, we have been witnesses, actors and victims of rapid changes on a global scale. The consequences of the socio-economic and political crises seemingly driven by the global pandemic have been becoming more visible. The very act of venturing into ontological explorations of various aspects of contemporaneity might be deja vu, overdramatized and reminiscent of the early twentieth century. The processes underlying socio-political and economic changes have been the subject of research in social sciences and humanities throughout centuries, and they are particularly perceptible in language and literature. Their various aspects are inherent to both language and literature. In language, these changes are traced in the field of synchrony and diachrony at almost all grammatical levels, from the phonetic to the phonological, the morphological through morphosyntactic and syntactic, and they are visible in the discourse. If processual exploration is not long overdue in the post-pandemic times, riddled with war, socio-economic crises and overall uncertainty, we invite you as academics to participate in panels and discussions designed to provide an overall (processual) framework that describes these processes of contemporaneity - in language, literature and society overall.
Reflecting on an Indigenist Methodology in Indigenous Family and Community Engagement Research
Authors: Washington Shaneé A.
Published: April 2023

Indigenous and non-Indigenous researchers of Indigenous peoples and contexts have argued that any research involving Indigenous communities must align with Indigenous paradigms, follow critical cultural protocols, and promote emancipatory agendas. This ensures ethical and culturally appropriate research practices that prioritize community needs while placing the interests, experiences, and knowledge of Indigenous peoples at the center of research methodologies. Drawing from canonical scholars who have explicated and refined, over time, the meaning of Indigenous methodologies, this article first offers my synthesis of their collective conceptualizations. Next, I reflexively consider my application and, at times, misapplication of Indigenous methodologies with Indigenous and white participants in a study I carried out exploring Indigenous family and community-school engagement. I conclude by offering some implications for researchers who desire and have the responsibility to conduct research in ethical ways that honor Indigenous ways of knowing, being, and doing in research with/in Indigenous communities.
Área crítica e subcrítica de prótese sobre implante
Authors: Welter Natan Henrique Marcon
Published: April 2023

Na prática da Implantodontia, para que se possa proporcionar ao paciente um implante semelhante ao dente natural, é necessária a definição de contornos gengivais naturais e harmônicos. Estes contornos compõem a área crítica e subcrítica do perfil de emergência, que influenciam nos aspectos estéticos da prótese sobre o implante, afetando o perfil dos tecidos moles e a estabilidade da margem gengival. O objetivo da pesquisa foi analisar o que os estudos científicos localizados tratam sobre áreas críticas e subcríticas da prótese sobre implante, realizando-se uma revisão de literatura qualitativa e descritiva de estudos publicados entre 2009 e 2020, abordando definições de área crítica e subcrítica, sua localização bem como a atenção que deve ser dada a estas antes, durante e depois da colocação do implante, no acompanhamento dos resultados. Concluiu-se que as áreas crítica e subcrítica da prótese sobre implante são importantes para a estabilidade deste, e dependem da correta manipulação de tecidos moles e duros para que os contornos sejam bem definidos, e assim se alcançar o sucesso do procedimento.
Bichectomia e a harmonização orofacial
Authors: Ribeiro Évellin Lima
Published: April 2023

A face é o cartão de visita do ser humano através dela nos expressamos e relacionamos. Assim os procedimentos estéticos têm plena notoriedade para exaltar o belo e melhorar aspectos faciais que incomodam alguns pacientes, como o rosto arredondado. A bola de Bichat foi descrita na literatura pela primeira vez em 1732, nas crianças ela tem importante função no processo de amamentação. A bichectomia é o procedimento cirúrgico realizado em consultório odontológico, sob anestesia local, sem cicatrizes visíveis, que visa remoção parcial do corpo adiposo da bochecha. A remoção proporciona ao paciente uma face mais harmônica, realçando os ângulos da região do ramo da mandíbula e da região malar, diminuindo o volume do terço médio e inferior da face, dando aspecto mais delgado ao rosto. Este trabalho teve como objetivo apresentar uma revisão de literatura sobre o procedimento de bichectomia para fins estéticos. A cirurgia é simples, de curta duração, sem necessidade de internação cirúrgica. Após 6 meses do procedimento, ocorreu a total reabsorção do edema em tecidos moles. Quando bem indicada e executada, a bichectomia oferece resultados harmônicos em relação aos terços da face.
Comparação entre pino de fibra de vidro e pino metálico fundido: revisão de literatura
Authors: Wagner Angela Aparecida
Published: April 2023

Os pinos dentários são utilizados na odontologia com o propósito de repor a estrutura dental perdida. A tarefa de selecionar o melhor tipo de pino para um dente com ampla destruição coronária, tratado endodonticamente, pode ser um exercício complexo e impreciso para o cirurgião-dentista. Visto que, o pino ideal deve atender aos requisitos biológicos, mecânicos e também estéticos. Desse modo, o objetivo desta revisão de literatura, foi fazer uma comparação entre os pinos metálicos fundidos e os pinos de fibra de vidro. Diante das informações coletadas e analisadas, foi possível concluir que se existir pelo menos 2 mm de estrutura coronária remanescente, qualquer sistema de pinos poderá apresentar bons resultados clínicos. Por isso, o cirurgião-dentista deve analisar e planejar individualmente cada caso, e saber selecionar o pino mais indicado para poder oferecer o melhor tratamento para o paciente.
A importância do perfil de emergência na colocação do implante
Authors: Welter Natan
Published: April 2023

Na prática da implantodontia, para que se possa proporcionar ao paciente um implante semelhante ao dente natural, é necessária a definição de contornos gengivais naturais e harmônicos. Os aspectos anatômicos e biológicos do elemento dental e de suas estruturas de suporte e proteção, e os princípios que envolvem estes aspectos devem ser respeitados no momento da colocação do implante, entre eles, o perfil emergencial. Isso inclui observar a área crítica e subcrítica do perfil de emergência, que influenciam nos aspectos estéticos da prótese sobre o implante, afetando o perfil dos tecidos moles e a estabilidade da margem gengival. O objetivo da pesquisa foi analisar, através de uma revisão de literatura, a importância do perfil de emergência no sucesso do implante, realizando-se uma revisão de literatura que abordou definições de perfil de emergência, destacando-se a área crítica e subcrítica, sua localização bem como a atenção que deve ser dada a estas antes, durante e depois da colocação do implante, no acompanhamento dos resultados. Concluiu-se que o perfil emergencial é fator determinante para o sucesso na área da implantodontia, porque influencia na estabilidade do implante, e depende da correta manipulação de tecidos moles e duros para que os contornos sejam bem definidos, e assim se alcançar o sucesso do procedimento.