bluuebunny/crossref_metadata_2025 huggingface dataset:
Plataforma computacional de acoplamiento de proteínas basado en plantillas
Authors: Román-Brenes Ricardo , Siles-Canales Francisco , Zamora-Mata Daniel
Published: March 2020

Se propone la creación de una Plataforma Biocomputacional para el acoplamiento de proteínas que reduce el tiempo computacional al agrupar los datos previo al alineamiento de cuerpos rígidos. Utilizando datos del proyecto Dockground, se crearán modelos usando múltiples métodos de agrupación que asignarán cada proteína a un grupo para que, al realizar la búsqueda de pares, no se realice una búsqueda a fuerza bruta, sino una acotada. Esto reducirá el tiempo que requiere una conformación en ser procesada sin perder precisión.
Diseño de un prototipo de órtesis para mano con actuadores neumáticos
Authors: Tortós-Vinocour Pablo Enrique , Valverde-Gutiérrez Sofia , Vílchez-Moge Marta Eugenia
Published: March 2020

En Costa Rica, en los últimos años se registró un aumento en la necesidad de dispositivos protésicos y ortésicos, en poblaciones con diabetes, parálisis cerebral y adulta mayor, algunos de los dispositivos son elaborados en el país, sin embargo, otros como las ortesis de mano son raramente producidos en la región. El uso de robótica suave en la réplica del movimiento humano ha venido en crecimiento,por lo que tomando en cuenta lo desarrollado por Deimel and Brock[3] y en el Laboratorio de Simulación y Bioingeniería(SIBILA) se pretende crear una órtesis de mano con robótica suave para un paciente con parálisis cerebral, el cual tiene problemas para asir objetos con su mano derecha. Se busca mejorar la fuerza de agarre y la posición de los dedos. El proyecto se divide en 3 partes: desarrollo de una réplica de la mano del paciente, elaboración de los músculos neumáticos y elaboración de un sistema de control  por voz. El resultado es una órtesis de actuación neumática que permite asir objetos de distintas formas y brinda fuerza a los dedos, además la órtesis se ajusta al modelo de la mano del paciente. Se recomienda utilizar un silicon e hilo más resistente, además de realizar pruebas con el guante colocado sobre la réplica de la mano.
Infraestructura de HPC del Colaboratorio Nacional de Computación Avanzada, Kabré
Authors: Gómez-Sánchez Isaac Eduardo , Umaña-Jiménez Jean Carlo , Arce-Montero Melissa
Published: March 2020

La supercomputadora Kabré es un clúster de computación de alto rendimiento (HPC) que proporciona las herramientas necesarias para ejecutar proyectos específicos. En este documento, presentamos la infraestructura de dicha supercomputadora establecida en Colaboratorio Nacional de Computación Avanzada (CNCA), cómo se define su estructura según las necesidades del usuario y algunas recomendaciones para mejorar el uso y el desarrollo de una infraestructura de clúster HPC para fines de investigación científica.
Bridging The CPA Exam Gap: Do Internships Matter?
Authors: Hairston Stephanie , Harter Charles , McKay Britton
Published: March 2020

In this paper we consider whether experience gained on the job through an internship results in knowledge that can help with passing the CPA exam. It would seem that a candidate for the CPA exam would be better prepared if they had the combination of education and practical experience. We examine the CPA exam performance of 72 graduate students that completed a public accounting internship prior to sitting for the CPA exam compared to 98 graduate students that did not complete an internship in public accounting. Our analysis indicates that on average students completing internships score higher on all parts of the CPA exam. In addition, on average, students completing internships had a higher overall pass rate for each section of the exam, with the pass rate for the Regulation (REG) section being significantly higher for students that have completed internships; we also find that on average students with internships pass 2 sections of the exam prior to graduation as compared to 1.69 for students that have not completed internships.
Análisis funcional y microbiológico de derivados lácteos y cárnicos
Authors: Rodríguez Andrade Ruth , Góngora Marín Paula Alejandra , Amado Agudelo Natalia , Santamaría Gaona Juan Pablo , Cerquera Gómez Pedro Pablo
Published: March 2020

Este texto le permite al zootecnista identificar los procedimientos básicos a desarrollar con las carnes frescas tanto para conocer sus propiedades funcionales como para hacer un análisis microbiológico que permita asegurar el cumplimiento de la normativa legal vigente en Colombia.
Anksiozne motnje pri otrocih in mladostnikih
Authors: Dobnik Renko Bernarda
Published: March 2020

Anksioznost je ena izmed najpogostejših duševnih motenj v otroštvu in mladostništvu. Če se anksioznih motenj ne zdravi, se simptomi sčasoma stopnjujejo in nadaljujejo v kasnejša razvojna obdobja. Pri zdravljenju je ključna čim zgodnejša obravnava, saj je za osebe z nezdravljeno anksiozno motnjo značilna manjša učna učinkovitost, opustitev šolanja in socialna izolacija. Učinkovita metoda zdravljenja je kognitivno-vedenjska terapija, glavna načela smo povzeli v tem članku.
Kognitivno-vedenjska terapija pri otrocih in mladostnikih s kronično bolečino
Authors: Stropnik Staša , Krkoč Vesna
Published: March 2020

Kronična ali ponavljajoča se bolečina v otroštvu je dokaj pogost pojav, s katerim se psihologi srečujemo v okviru multidisciplinarne zdravstvene obravnave. V tem članku skušava avtorici osvetliti teoretična izhodišča in praktične usmeritve pri obravnavi kronične bolečine pri otroku in mladostniku. Za ustrezno razumevanje kronične bolečine je treba upoštevati biološke/fiziološke, kognitivne, čustvene in socialne dejavnike. V prvem delu članka skušava povzeti izsledke novejših študij glede povezanosti navedenih dejavnikov z razvojem kronične bolečine. V ospredje postavljava teorijo razumevanja in obravnave kronične bolečine pri otroku in mladostniku, ki izhaja iz kognitivno-vedenjske teorije. V drugem delu članka so uporabno in sistematično predstavljene metode kognitivno-vedenjske terapije, od ocenjevanja bolečine, spremljanja oz. monitoringa v terapiji do psihoedukacije, kognitivnih in vedenjskih tehnik.
Psihološki vidiki proceduralne bolečini pri otroku in uporaba kognitivno-vedenjskega pristopa
Authors: Bürger Lazar Martina , Sever Mateja
Published: March 2020

Zdravstveni posegi so lahko za otroka zelo stresna izkušnja. Negativne izkušnje s pogostimi bolečimi posegi lahko povzročijo pomembnejše dolgoročne psihološke posledice. Zato je poleg farmakološke priprave otroka na zdravstvene posege pomembna tudi uporaba različnih kognitivno-vedenjskih tehnik, ki pomagajo blažiti distres in jakost zaznane bolečine. Ni pa standardne metode, ki bi bila za vse otroke enako primerna. Izbira le-te mora temeljiti ne le na invazivnosti in trajanju samega posega, temveč tudi na poznavanju dejavnikov, ki vplivajo na doživljanje bolečine, ter na osebnih značilnostih otroka. Izsledki raziskav, v katerih so proučevali učinkovitost različnih psiholoških pristopov pri pripravi otrok na (boleče) zdravstvene posege, do sedaj najbolj potrjujejo učinkovitost kognitivno-vedenjskih ukrepov in nagovarjajo k njihovi uporabi v klinični praksi.
Utilization of Paku Uban (Nephrolepis biserrata) Extract as a Molting Stimulant of Mud Crabs (Scylla spp.) in Traditional Ponds
Authors: Maulianawati Diana , Rukisah Rukisah , Awaludin Awaludin , Guntur Muhammad Iswan
Published: March 2020

HighlightsThe Paku Uban (Nephrolepis biserrata) was identified and analyzedThe ability of paku uban to stimulated molting process of Scylla sp was analyzedThe paku uban (Nephrolepis biserrata) could increase the presentation of molting and accelerate molting processAbstractMud crab (Scylla spp.) is a fishery commodity with high economic value. For this reason, efforts to increase production are required with a more effective applicative technology. This study aims to determine the molting response and survival rate of mud crabs injected with paku uban leaf  extract (N. biserrata) at different doses. The study was conducted for 30 days, located in Tibi Island, Tanah Lia District, Tanah Tidung. The design used in this study was a completely randomized design (CRD) with five treatments and eight replicates. Mud crabs weighing 80 - 150 g were tested in K1 (without injection), K2 (controlled injection), P1 (100 ppm extract), P2 (125 ppm extract) and P3 (150 ppm extract). The effectivity of paku uban (N. biserrata) extract with the highest percentage of molting of 50% took place at P3, 37.5% at P2, and 25% at P1. The lowest levels of molting percentage were at K1 and K2 by 0%. The fastest molting period was ten days at P2, and the longest was 29 days at P1. The highest weight growth reached 33.75 g at P3, followed by P2 and P1 with 31 and 18.75 g, respectively. The survival rate of mud crabs for all treatments reached 100%. The results of the analysis of variance indicated a significant bet effect (P < 0.05) on the molting and weight growth percentage. The BNT test suggested that a dose of 150 ppm was the optimum treatment.
Study on Community Structure of Commercial Sea Cucumber in Intertidal Zone, Southeast Moluccas, and Tual, Moluccas
Authors: Jasmadi Jasmadi , Wirawati Ismiliana , Tegar Suryaningtyas Indyaswan , Permadi Sandi
Published: March 2020

HighlightEight species of sea cucumber was found in four intertidal location in Southeast Moluccas and Tual watersHolothuria atra had the highest densitySea cucumber biodiversity in Southeast Moluccas and Tual waters categorized as lowLocal culture can be used for sustainability of sea cucumber resources management  AbstractA study on the community structure of sea cucumber in Southeast Moluccas and Tual needs to be done due to the important role of sea cucumber in both ecologically and economically sustainability. This study aimed to investigate the community structure of sea cucumber in this region as one of the supporting information for the utilization and management of the resources. A survey was conducted by sweeping the target area, by walking and also snorkeling. The location where each sea cucumber found was marked using a GPS, the specimen was weighed, and some were preserved for species analysis. Water quality was measured at each location, while the substrate and vegetation were recorded. This study revealed different composition of species in the investigated area. As many as 8 species of sea cucumber were found, in which four were of genus Holothuria, three were of genus Stichopus and the rest were of genus Bohadschia. Species H. atra has the highest density. In general, the diversity index was relatively low (< 2), the evenness index was 0-81 indicating that the community was depressed. Certain species dominated at most of the investigated sites (0.50-1), and a low margalef index is 0-1.7. To conclude, the community structure of sea cucumber in Tual and Southeast Moluccas was in a depressed condition.
Application of Probiotics for Organic Matter and Enhancement of Growth Performance in White Shrimp (Litopenaeus vannamei)
Authors: Jefri Muhammed , Satyantini Woro Hastuti , Sahidu Adriana Monica , Nindarwi Daruti Dinda , Rozi Rozi
Published: March 2020

HighlightsLitopenaeus vannamei has been established as alternative to Penaeus monodon to shrimp farming in several countries.Increased importance of in situ microorganisms both in regulating biogeochemical cycles within the culture environment and in directly affecting shrimp growth and survival.To improve water quality in aquaculture is the application of probiotics and/or enzymes to ponds. AbstractIntensive shrimp farming has raised environmental issues due to aquaculture pollution, which is caused by uneaten feed, feces, organic matter, and toxic compounds (ammonia and H2S). One way to solve this issue is by using probiotics. Thus, this study aimed at investigating the effect of probiotic administration (Pseudomonas sp. and Bacillus sp.) at varying concentrations on total organic matter in the rearing water, feed conversion ratio, feed efficiency, and growth rate of white shrimp (Litopenaeus vannamei). This study used a Completely Randomized Design consisting of four treatments: T0 (without the probiotic supplementations), T1 (probiotics at 106 CFU/ml), T2 (probiotics at 107 CFU/mL), T3 (probiotics at 108 CFU/mL) with three replicates each. The results showed that the administration of probiotics at different concentrations had a significant effect on the total amount of organic matter, feed conversion ratio, feed efficiency, and specific growth rate of white shrimp. Administration of probiotics at a concentration of 107 CFU/ ml had the lowest organic matter in the rearing water, 138 mg /Lt. While probiotic administration at 108 CFU/ ml gave the lowest feed conversion ratio (1.22), the highest feed efficiency (81.57%) and the best growth rate (2.25%/day). This research suggests that the administration of 107-108 CFU/ ml probiotics could be applied to reduce organic content in the rearing water and improve the growth performances of white shrimp.
Spatial Distribution and Contamination Assessment of Lead (Pb) in the Seawater and Surface Sediments of the Coastal Area of Prigi Bay, Trenggalek, East Java
Authors: Yona Defri , Vernandes David , Kasitowati Rarasrum Dyah , Sari Syarifah Hikmah Julinda
Published: March 2020

HighlightsConcentration of lead (Pb) in the surface water and sediment were analyzedThe ecological risks of metal in the ecosystem were assessedPb concentration in the surface water and sediment were observed in the similar range Pb in the study areas has low ecological risk indexConcern on Pb contamination in Prigi Harbor is neededAbstractThis study attempts to measure the spatial distribution of Pb in the seawater and surface sediments and to analyze its potential harmful effect in the surface sediments of the coastal areas of Prigi Bay, Trenggalek. Prigi Bay has been considered as one of the harbors with substantial activities from fisheries, tourism, and domestic events in Indonesia. These activities may discharge heavy metals, e.g., lead (Pb) into the environment and bring hazard to animal and human life. Data for Pb concentrations were collected from two stations near Prigi Harbor (Stations 1 and 2), one station in the Prigi Beach (Station 3) and two stations near the river mouths (Stations 4 and 5). Water quality parameters (temperature, salinity, pH, and DO) were also measured. Stations 1 and 4 displayed a higher concentration of Pb in the seawater than in the surface sediments. On the other hand, Stations 3 and 5 showed a higher concentration of Pb in the surface sediments than in the seawater. Pb concentration in the seawater was 0.22-0.60 mg/kg, and in the surface, sediments were in the range of 0.40-0.57 mg/kg. According to the analysis of contamination factor (CF), the study sites have a low degree of contamination from heavy metal Pb (CF < 1). The result was also supported by the potential toxicity of Pb to the benthic environment around Prigi Bay that was still considered low (E < 40). In spite of the low degree of contamination and low potential toxicity from Pb, concern regarding the heavy metal pollution in the study areas is still needed due to substantial activities that can contribute to the accumulation of heavy metal in a long time.
Trends in the Uses of Spirulina Microalga: A mini-review
Authors: Nege Aondohemba Samuel , Dewi Masithah Endang , Khotib Junaidi
Published: March 2020

HighlightsTrends in the uses of Spirulina over different decades were critically examinedFindings from surveyed literature indicated that Spirulina utilization was mainly focused on its food and feed potential before the last 20-30 yearsThe review observed that research focused on the health and pharmaceutical uses, biofertilizer, bioplastic, cosmetic, bioenergy and pollution control applications of Spirulina are trends that sprouted out within the last 20-25 years.The review has successfully compiled numerous uses of Spirulina microalga for easy readership by readers since many studies have been performed on the uses Spirulina but reviews of this type spanning through different beneficial aspects of  Spirulina are still scarce. Hence, this review fills such gap.       AbstractThere is a need to have a single document that summarises the present day uses of Spirulina. In this review, the research trend on the health and other applications of Spirulina microalga was critically evaluated. In terms of the health uses, antioxidant, antibacterial, and immunostimulant effects of Spirulina were emphasized. Other uses of the microalga discussed include the use of Spirulina for human and animal food, bioenergy, pollution and ecotoxicology control, cosmetics, bioplastics and biofertilizers. Literature search revealed that Spirulina polysaccharides, phycocyanin size and content play a role in antioxidant activity and DNA repair. The double bonds and positions of –COOH and –OH in Spirulina phenol content and γ-linolenic fatty acids (γ-LFA) have antimicrobial activity. Some compounds in Spirulina improve immune, increase survival rate and enhance distribution of proteins like hepcidin and TNF-α in animal models. High protein, vitamins, fatty acids (FAs) and glycoproteins in Spirulina are easily digestible due to its lack of cellulose and can improve human and livestock growth. Spirulina produces biodegradable and non-toxic biodiesel and useful co-products. Absorption of heavy metals by chemisorption occurs in Spirulina. Phycocyanin and β-carotene of Spirulina increase skin health, Spirulina also cause high cell proliferation and aids wound healing. Bioplastics produced from Spirulina are biodegradable, non-toxic with high blends. Biofertilizers from Spirulina have little or no residual risks, adds soil Nitrogen through Spirulina Nitrogen fixation ability. In addition, the survey of published works on Spirulina for the past two decades indicates that more research is been carried out in recent years using Spirulina, especially studies involving its health potentials and those concerned with molecular analysis. In conclusion, Spirulina is an exceptional commodity with numerous applications, and probably, some of its compounds causing those effects are yet to be isolated and that is one area for further research.
Fish Feed Formulation with the Addition of Sludge of Dairy Wastewater and Fermented Wheat Bran
Authors: Pangestika Widya , Putra Sugili
Published: March 2020

HighlightColloids in dairy wastewater could be destabilized by adding ferric chlorideAspergillus niger could increase protein and decreased the crude fiber in wheat branWheat bran fermentation could be carried out in room temperature during three daysFish feed formulation was conducted by solving simultaneous linear equationsSludge of dairy wastewater and fermented wheat bran could be utilized as fish feedAbstractDairy wastewater contains suspended solids, which are very difficult to settle naturally. This waste could be treated by using ferric chloride, due to its ability to bind suspended solid and to form brown solid of Iron (III) hydroxide. The optimal amount of FeCl3 in coagulating dairy wastewater was 0.15 g of FeCl3 for every 250 mL of wastewater. This sludge could be utilized into something useful for the organism. The sludge of dairy wastewater could be mixed with other ingredients to make fish feed. Wheat bran, one of the ingredients used to make fish feed, was fermented using Aspergillus niger to increase the crude protein content and to lower crude fiber content. The addition of fermented wheat bran in fish feed formulation could increase the crude protein content in feed B (which had 0.085% iron) by 5.78% and feed C (which had 1.703% iron) by 5.17%. By using simultaneous linear equations, fish feed formulation was conducted by adding sludge of dairy wastewater, fermented wheat bran, rebon flour, starch, and vitamin C. In this research, two variations of fish feeds were made (feed B and feed C). The results indicated that feed B and feed C had better stability and buoyancy than feed A, as the commercial feed. Feed C also had the biggest crude protein of all feeds, amounting to 32.057%. Feed C also gave the best result in increasing nile tilapia’s growth rate. The result showed that sludge of dairy wastewater and fermented wheat bran could be added to fish feed formulation.
Development of Vietnamese Medical Staff in the Period of Accelerated Industrialization and Modernization of the Country and International Integration
Authors: Nhuong Do Thi , Anh Chu Tuan
Published: March 2020

Medical staff holds a pivotal role in the Vietnamese health system, and is crucial to the efficiency and quality of health care services in Vietnam. It is their professional and dedicated work that is a permanent basis to guarantee protection of and care for people’s health in the provision of health care services to people in all regions, including remote areas, borders and islands. The continuous growth in the quantity and quality of health workers in Vietnam has affirmed the right leadership of the Communist Party of Vietnam in building this health workforce over the years.
High-Resolution Inundation Mapping for Heterogeneous Land Covers with Synthetic Aperture Radar and Terrain Data
Authors: Aristizabal Fernando , Judge Jasmeet , Monsivais-Huertero Alejandro
Published: March 2020

Floods are one of the most wide-spread, frequent, and devastating natural disasters that continue to increase in frequency and intensity. Remote sensing, specifically synthetic aperture radar (SAR), has been widely used to detect surface water inundation to provide retrospective and near-real time (NRT) information due to its high-spatial resolution, self-illumination, and low atmospheric attenuation. However, the efficacy of flood inundation mapping with SAR is susceptible to reflections and scattering from a variety of factors including dense vegetation and urban areas. In this study, the topographic dataset height above nearest drainage (HAND) was investigated as a potential supplement to Sentinel-1A C-Band SAR along with supervised machine learning to improve the detection of inundation in heterogeneous areas. Three machine learning classifiers were trained on two sets of features SAR only (VV & VH) and VV, VH & HAND to map inundated areas. Three study sites along the Neuse River in North Carolina, USA during the record flood of Hurricane Matthew in October 2016 were selected. The binary classification analysis (inundated as positive vs. non-inundated as negative) revealed significant improvements when incorporating HAND in several metrics including classification accuracy (ACC) (+37.1%), true positive rate (TPR) (+51.2%), and negative predictive value (NPV) (+23.7%), A marginal improvement of +1.4% was seen for positive predictive value (PPV), but true negative rate (TNR) fell -15.1%. By incorporating HAND, a significant number of areas with high SAR backscatter but low HAND values were detected as inundated which increased true positives. This in turn also increased the false positives detected but to a lesser extent as evident in the metrics. This study demonstrates that HAND could be considered a valuable feature to enhance SAR flood inundation mapping especially in areas with heterogeneous land covers with dense vegetation that interfere with SAR.
Effect of Artificial Aging Treatment and lubrication Modes on the Machinability of A356 Cast Alloys
Authors: Alliche Mohamed Amine , Djebara Abdelhakim , Zedan Yasser , Songmene Victor
Published: March 2020

This article discuss the effects of heat treatment and lubrication modes on the machinability of an A356 alloy (Al-Si-Mg); the alloy is studied as-received, with solution heat-treated alloy (SHT) as well as with an alloy that is solution heat-treated and then aged at 155, 180 and 220 °C. In the course of machinability evaluation, several criteria including cutting force, surface roughness, tool wears and burr analysis (chip) were studied. The results and analysis in this work indicated that the selected machinability criteria are important and necessary to effectively evaluate the machinability of A356 alloys. The machinability of both materials and tools were estimated in terms of cutting force, chip thickness ratio and burr formation, flank wear and roughness. The effects of different cutting parameters (cutting speed and feed rate) and lubrication modes (dry, mist and wet) on the machinability of the A356 cast alloy were also examined. The influence of heat treatments on the burr formation and surface quality was clearly revealed by the experimental results. Experimental work revealed that cutting forces were influenced significantly by aging and cutting speed. However, the different aging at 155, 180, and 220 °C and the cutting speed significantly affected the machinability of the A356 cast alloy. The results obtained show that a better drilling performance in terms of surface quality occurs at a high feed rate, with dry drilling and artificial aging at T6.
The Ongoing COVID-19 Epidemic Curves Indicate Initial Point Spread in China With Log-Normal Distribution of New Cases per Day With a Predictable Last Date of the Outbreak Version 3: Test for When After a Peak in Daily Cases the Predicted Equation Becomes Reliable and Use of the Derivative of the Equation to Detect Time of Key Changes Determining the Length of the Outbreak
Authors: Olsson Stefan , Zhang Jing
Published: March 2020

During an epidemic outbreak it is useful for planners and responsible authorities to be able to plan ahead to estimate when an outbreak of an epidemic is likely to ease and when the last case can be predicted in their area of responsibility. Theoretically this could be done for a point source epidemic using epidemic curve forecasting. The extensive data now coming out of China makes it possible to test if this can be done using MS Excel a standard spreadsheet program available to most offices. The available data is divided up for whole China and the different provinces. This and the high number of cases makes the analysis possible. Data for new confirmed infections for Hubei, Hubei outside Wuhan, China excluding Hubei as well as Zhejiang and Fujian provinces all follow a log-normal distribution that can be used to make a rough estimate for the date of the last new confirmed cases in respective areas. In the version 2 continuation work, 9 additional days were added for the Chinese data to evaluate the previous predictions. The extra data then available from China follows the previous predicted trend supporting the usefulness of this simple technique. In the version 2 we also tested the feasibility for a non-specialist to make similar predictions using additional data from S Korea now available. In this third continuation the predictions for Version 2 are evaluated for S Korea and fits well the beginning of the decline but it seems to be difficult to bring down numbers of cases per day under about 100 new cases per day, potential reasons for this is discussed. To further evaluate when in a prediction becomes reliable the Chinese data was used to evaluate to make predictions for each day around the peak in number of cases and after2-3 consecutive days of decreasing new cases per day the prediction becomes reliable. In version 3 data for Italy just reaching this point was used to make further predictions for that country. A second new analysis was also added to use the fitted equation to detect when the acceleration of new cases per day stopped increasing exponentially. In the Chinese case this measured point coincides with the date of the complete Hubei lockdown and in the new Italian analysis it coincides with the mandatory Italian lockdown. Predicted dates for the end of the Italian outbreak is also added.
Virtual Screening and Molecular Dynamics Simulation Suggest Valproic Acid Co-A could Bind to SARS-CoV2 RNA Depended RNA Polymerase
Authors: Bhavesh Neel Sarovar , Patra Anupam
Published: March 2020

SARS-CoV2 RNA depended RNA polymerase is an essential enzyme for the survival of the virus in hosts as it helps in the replication of viral RNA. There are no human polymerases that share either sequence or structural homology with viral RNA depended RNA polymerase. These make it a good target for inhibitor discovery, as a specific inhibitor cannot cross-react with the human polymerases. We have used virtual screening, docking, binding energy calculation and simulation to show that valproic acid Co-A, a metabolite from prodrug valproic acid, forms stable interaction with nsP12 of CoV. Our results suggest valproic acid Co-A could be a potential inhibitor of nsP12 of SARS-CoV2.
Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein
Authors: Singh Bipin
Published: March 2020

The recent outbreak of novel coronavirus (2019-nCoV or SARS-CoV-2) and its spread to the whole world is currently posing one of the major threat to human health and the world economy. It has been suggested that 2019-nCoV is similar to SARS-CoV based on the genome sequence comparison. Despite the genomic similarity between SARS-CoV and SARS-CoV-2, the spike glycoprotein and receptor binding domain in SARS-CoV-2 shows considerable difference compared to SARS-CoV, due to the presence of several point mutations. We analyzed the receptor binding domain (RBD) from recently published 3D structure of spike glycoprotein of SARS-CoV-2 and compared with RBD of SARS-CoV. The observations highlight few important features of RBD in the light of the recently published findings from the 3D structures of spike glycoprotein and its complex with human angiotensin-converting enzyme 2 (ACE2) (Yan, R., et al. (2020); Wrapp, D., et al. (2020); Walls, A. C., et al. (2020)).
Assessment of the Design for Assembly Processes Using Fuzzy Logic
Authors: Matuszek Józef , Seneta Tomasz , Moczała Aleksander
Published: March 2020

The paper presents methodology for designing the production process of a new product from the point of view of the assembly operations technology criterion (Design for Assembly - DFA) in the conditions of high-volume production. Mentioned are DFA methods and techniques used in the implementation of a new product. Author presents a new method for assessing design for manufacturability based on fuzzy variables based on fuzzy variables. An example was given to illustrate the proposed course of action
Design and Implementation of a New CFAR Based on Weighted and Statistical Algorithms
Authors: Saeed Thamir , Hatem Gufran , Abdul Sadah Jafar , Ziboon Hadi
Published: March 2020

In the radar system, detection represents a basic and important stage in the receiver side. The detection process is based on the thresholding criteria; two philosophies of this criteria, constant and adaptive threshold. The constant threshold is simple in design, but it has a mis-detection and does not control the false alarm rate. As for the adaptive threshold, it is powerful in target detection, and better control of the false alarm rate, where it is called Constant False Alarm Rate (CFAR). Lots of research in the CFAR design, but the gap in the previous works is that there is no CFAR algorithm can be working with all or most environmental fields and all or most target situations.In this paper, The CFAR, which can work with the most environment and most of the target situations, has been presented. The producing the design and implementation of the new practical CFAR processor is presented. Where, the new CFAR is a combination of the properties of three different CFAR algorithm (CA, OSGO, and OSSO), and from two different families; averaging and statistical. Where it has overperformed of it's is 97.25% for simulation and 96.25% for the implementable version for different target situations. The simulation analysis is made by using Matlab 2015, while the implementation is done by using Xilinx Spartan 700 3a.
Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding and Antibody-dependent Enhancement (ADE)
Authors: Schatzmann Peron Jean Pierre , Nakaya Helder
Published: March 2020

The world is currently going through a serious pandemic of viral infection with SARS-CoV-2, a new isolate of coronavirus, resembling and surpassing the crisis that occurred in 2002 and 2013 with SARS and MERS, respectively. SARS-CoV-2 has currently infected more than 142,000 people, causing 5,000 deaths and reaching more than 130 countries worldwide. The very large spreading capacity of the virus clearly demonstrates the potential threat of respiratory viruses to human health, alarming governments around the world that preventive health policies and scientific research are pivotal to overcoming the crisis. Coronavirus disease 2019 (COVID-19) causes flu-like symptoms in most cases. However, approximately 15% of patients will need hospitalization, and 5% require assisted ventilation, depending on the cohorts studied. What is intriguing, however, is the higher susceptibility of elderly individuals, especially those who are more than 60 years old and have comorbidities, including hypertension, diabetes and heart disease. In fact, the death rate in this group may be up to 10-12%. Interestingly, children are somehow protected and not included as a risk group.Thus, here, we discuss some possibilities of molecular and cellular mechanisms by which elderly subjects may be more susceptible to severe COVID-19. In this sense, we raise two main points: i) increased ACE-2 expression in pulmonary and heart tissue of chronic angiotensin 1 receptor (AT1R) blocker users and hypertensive individuals and ii) antibody-dependent enhancement (ADE) after previous exposure to other circulating coronaviruses. We believe these are pivotal points for a better understanding of the pathogenesis of severe COVID-19 and must be addressed with attention by physicians and scientists in the field.
Roles for the SNAP25 Linker Domain in the Fusion Pore and a Dynamic Plasma Membrane SNARE Acceptor Complex
Authors: Holz Ronald , Bittner Mary
Published: March 2020

A recent paper demonstrates the importance of the linker region joining the two SNARE motifs of the neuronal t-SNARE SNAP25 for maintaining rates of secretion with roles for distinct segments in speeding fusion pore expansion (Shaaban et al., 2019, Elife. 8). Remarkably, lipid perturbing agents rescue a palmitoylation-deficient phenotype that includes slow fusion pore expansion, suggesting that protein-protein interactions have a role not only in bringing together the granule or vesicle membrane with the plasma membrane but also in orchestrating protein-lipid interactions leading to the fusion reaction. Furthermore, biochemical investigations demonstrate the importance of the C-terminal domain of the linker in the formation of the plasma membrane t-SNARE acceptor complex for synaptobrevin2 (Jiang, et al., 2019, FASEB J. 33:7985-7994;Shaaban et al., 2019, Elife. 8). This insight, together with biophysical and optical studies from other laboratories (Wang, et al., 2008, Molecular Biology of the Cell. 19:3944-3955; Zhao, et al., 2013, Proc Natl Acad Sci U S A. 110:14249-14254) suggests that the plasma membrane SNARE acceptor complex between SNAP25 and syntaxin and the resulting trans SNARE complex with the v-SNARE synaptobrevin form just milliseconds before fusion.
Liquid Metal Flow under Traveling Magnetic Field: Solidification Simulation and Pulsating Flow Analysis
Authors: Shvydkiy Evgeniy , Baake Egbert , Köppen Diana
Published: March 2020

Non steady applied magnetic field impact on a liquid metals has good prospects for industry. For a better understanding of heat and mass transfer processes under these circumstances, numerical simulations are needed. A combination of finite elements and volumes methods was used to calculate the flow and solidification of liquid metal under electromagnetic influence. Validation of numerical results was carried out by means of measuring with ultrasound Doppler velocimetry technique, as well as with neutron radiography snapshots of the position and shape of the solid/liquid interface. As a result of the first part of the work, a numerical model of electromagnetic stirring and solidification was developed and validated. This model could be an effective tool for analyzing the electromagnetic stirring during the solidification process. In the second part, the dependences of the velocity pulsation amplitude and the melt velocity maximum value on the magnetic field pulsation frequency are obtained. It was found numerically the ability of the pulsating force action to develop higher values of the liquid metal velocity at a frequency close to the MHD resonance. Obtained characteristics give a more detailed description of the electrically conductive liquid behaviour under action of pulsating traveling magnetic field.
Synthesis and Characterization of New Selenonitrone Derivative and Its Effect on Breast Cancer Cell Line Viability in Vitro
Authors: Et al. Haddad
Published: March 2020

New nitrone and selenonitrone compounds were synthesized. The condensation method between N-(2-hydroxyethyl) hydroxylamine and substituted carbonyl compounds such as [benzil, 4, 4́-dichlorobenzil and  2,2́ -dinitrobenzil] afforded a variety of new nitrone compounds while the condensation between N-benzylhydroxylamine and substituted selenocarbonyl compounds such as [di(4-fluorobenzoyl) diselenide and (4-chlorobenzoyl selenonitrile] obtained selenonitrone compounds. The condensation of N-4-chlorophenylhydroxylamine with dibenzoyl diselenide obtained another type of selenonitrone compounds. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1H-NMR, 13C-NMR, MS and elemental analysis. The result spectra and the result of elemental analysis were verified the expected structure. The results of new selenonitron derivative (N1) effect on the MDA-MB-231 breast cancer cells in vitro revealed that is an increase in the proliferation of cells with increased concentrations of selenonitron at all periods of the times.
Spectral Properties of Hybrid of Rhodamine (6G) Dyes Doped Epoxy Resin Dissolved in Chloroform
Authors: Et al. Al-Hamdani
Published: March 2020

The research is dealing with the absorption and fluorescence spectra for the hybrid of  an Epoxy Resin doped with organic dye Rhodamine (R6G) of different concentrations (5*10-6, 5*10-5, 1*10-5, 1*10-4, 5*10-4) Mol/ℓ at room temperature. The Quantum efficiency Qfm, the rate of fluorescence emission Kfm (s-1), the non-radiative lifetime τfm (s), fluorescence lifetime τf and the Stokes shift were calculated. Also the energy gap (Eg) for each dye concentration was evaluated. The results showed that the maximum quantum efficiency 62 % and maximum stokes shift 96 nm was obtained in dye concentration 5*10-6 and 1*10-4. The energy gap ranges between 1.066 eV to 1.128 eV depending proportionally on the dye concentrations.
Thermal Conductivity Performance of Silica Aerogel after Exposition on Different Heating under Ambient Pressure
Authors: Al-sharuee Israa F.
Published: March 2020

The varied thermal conductivity (insulation) of silica aerogel with heating for different pH has been investigated, it has been depended on ambient pressure drying method in the preparing silica aerogel samples, also six different pH of samples (1, 2, 3, 7, 8 and 9) were treated under five degree of heating with (50,100,150,200 and 250) ᴼC. This technique is important to test the carry-outs hydrophobic silica to temperature without high-quality material changes in the basic characteristics. The hot-wire technique is used in this work to examine the thermal conductivity, Fourier Transform Infrared Spectroscopy (FTIR) depended to characterize the bonds and their artificial by heating. Results show that the samples affected by heating through decreasing the density leading to obtaining more insulation metal, moreover varied pH is an important role in thermal conductivity. The average thermal conductivity of all aerogel samples in this work is (0.01- 0.0061 mW m-10 C-1) this means that it is still below thermal conductivity for air equals to (0.02257) mW m-10 C-1 . Meanwhile, we concluded that the insulation property of silica aerogel is affected by heat treatment and gives it more thermal insulation property.
Estimation of Survival Function for Rayleigh Distribution by Ranking function:-
Authors: Et al. Hussein
Published: March 2020

In this article, performing and deriving te probability density function for Rayleigh distribution is done by using ordinary least squares estimator method and Rank set estimator method. Then creating interval for scale parameter of Rayleigh distribution. Anew method using   is used for fuzzy scale parameter. After that creating the survival and hazard functions for two ranking functions are conducted to show which one is beast.
Representation of Algebraic Integers as Sum of Units over the Real Quadratic Fields
Authors: Baddai Saad A.
Published: March 2020

In this paper we generalize Jacobsons results by proving that any integer  in   is a square-free integer), belong to . All units of  are generated by the fundamental unit  having the forms

our generalization build on using the conditions

This leads us to classify the real quadratic fields  into the sets  Jacobsons results shows that  and Sliwa confirm that  and  are the only real quadratic fields in .
New Approach for Solving Three Dimensional Space Partial Differential Equation
Authors: Et al. Enadi
Published: March 2020

This paper presents a new transform method to solve partial differential equations, for finding suitable accurate solutions in a wider domain. It can be used to solve the problems without resorting to the frequency domain. The new transform is combined with the homotopy perturbation method in order to solve three dimensional second order partial differential equations with initial condition, and the convergence of the solution to the exact form is proved. The implementation of the suggested method demonstrates the usefulness in finding exact solutions. The practical implications show the effectiveness of approach and it is easily implemented in finding exact solutions.

       Finally, all algorithms in this paper are implemented in MATLAB version 7.12.
Los geoparques como recurso para la enseñanza-aprendizaje del espacio geográfico en Educación Primaria: el paisaje de las áreas de montaña
Authors: Fernández Álvarez Rubén
Published: March 2020

El desarrollo de la red Geoparques ha supuesto el impulso de un nuevo elemento didáctico. Esta figura pretende convertirse en el nexo de unión entre el trabajo en las aulas y el que se lleva a cabo en el campo. Todo ello supone la creación de una red educativa de carácter internacional en la que los geoparques y los centros educativos intercambien conocimientos y técnicas que repercutan de forma positiva en el proceso de enseñanza-aprendizaje de los paisajes de montaña.
El lenguaje cartográfico en los libros de texto de geografía de secundaria en Brasil
Authors: Richter Denis , Martins Cavallini Gabriel
Published: March 2020

Este artículo es el resultado de una investigación que tuvo como objetivo analizar el lenguaje cartográfico presente en dos colecciones de libros de texto de geografía de secundaria en Brasil. Los mapas se analizaron en función de los diferentes tipos de representación cartográfica, así como las propuestas de cartografía escolar presentes en estos materiales didácticos. Como resultado, se observó que los mapas están restringidos a la cartografía euclidiana y contribuyen poco a la enseñanza de la geografía, teniendo como función principal solo localizar los fenómenos en el espacio.
Análisis de las guías docentes de las asignaturas de Cartografía en los actuales Grados de Geografía en España
Authors: Martínez Murillo Juan F. , Delgado Peña José Jesús
Published: March 2020

Este trabajo realiza una descripción de la enseñanza de la Cartografía en los actuales estudios universitarios de grado relacionados con la Geografía. Se ha generado una base de datos que incluye 26 grados en total, en los que al menos se imparte una asignatura de Cartografía. El resultado del análisis arroja una situación algo dispar entre grados en Geografía, especialmente, y la necesidad de incrementar los estudios en Cartografía y las nuevas tecnologías para hacer frente a las competencias cartográficas que debe adquirir el futuro investigador, docente o profesional geógrafo/a.
El desarrollo de las competencias sociales y cívicas en Ciencias Sociales: itinerario didáctico por los restos fenicios de Almuñecar (Granada)
Authors: Najarro Martín Ulises , Maroto Martos Juan Carlos
Published: March 2020

En el presente trabajo se propone un itinerario didáctico por los restos fenicios de la localidad de Almuñécar (Granada) dirigido a estudiantes de 1º de Educación Secundaria Obligatoria (ESO). A través del mismo ponemos especial interés en el desarrollo de las competencias sociales y cívicas (CSC). El legado histórico y patrimonial de Almuñécar es más que evidente, sin embargo, se constata la existencia de recursos/bienes que son insuficientemente conocidos y aprovechados desde un punto de vista didáctico. Se diseña, mediante el uso de un SIG, una cartografía con los principales Puntos de Interés Didáctico con presencia de restos arqueológicos. Además, se pretende trabajar una serie de actividades mediante un cuaderno de campo que permitan conocer el pasado fenicio de la ciudad, la importancia histórica de las colonizaciones fenicias, fomentar valores de sensibilización y de conservación, y elaborar un producto final para solicitar a las autoridades responsables actuaciones encaminadas a poner en valor el patrimonio histórico local.
Prevalence and factors associated with frailty in hospitalized older Patients
Authors: HAMMAMI Sonia , Zarrouk Amira , Piron Cecile , Almas Ioana , Sakly Nabil , Latteur Veronique
Published: March 2020

Background : Frailty is a multidimensional syndrome that leads to an increase of an age-related disorder of several physiological systems, and cognitive abilities decline. The aim of this study was to evaluate the prevalence of frailty among older persons in Belgium and we examined the factors associated with frailty with a principal focus en cognitive, dietary status, and inflammatory parameters Methods: A total of 124 participants (90 women, 34 men; age: mean ± SD: 85.9 ± 5.5 years) were studied, recruited from the Geriatrics department, Belgium. Nutritional, cognitive status and physical activity were assessed using Mini Mental State Examination score (MMSE), Mini Nutritional Assessment score (MNA), and Katz score, respectively. Frailty syndrome was evaluated using the modified Short Emergency Geriatric Assessment (SEGA) score. Medication and medical history were recorded. Analyzed biochemical parameters included C-reactive protein (CRP), complete blood count, blood creatinine, vitamin D level, and serum protein electrophoresis. According to SEGA score, participants were divided into non-frail (n=19), frail (n=25) and severely frail patients (n= 80). Results: The SEGA score was inversely correlated with MMSE, MNA and Katz score. SEGA score was negatively correlated to albumin levels (r = -0.30; p<0.001) and positively correlated to CRP, polypharmacy and age(r = 0.28, r = 0.37, r = 0.33 and p<0.01 respectively) . Logistic regression showed a strong association between frailty, Katz score, dementia, polypharmacy and living in nursing home. Conclusion : Our results provide useful information for understanding mechanisms of frailty. This will help to develop preventive strategies for the elderly at the pre-frailty stage.