bluuebunny/crossref_metadata_2025 huggingface dataset:
Ecoestética, naturaleza y arte contemporáneo
Authors: Ledezma Campos Miguel Angel , Paulín Ríos María Teresa , Caporal Gaytán Julia Magdalena , Rodríguez Arévalo Jesús
Published: January 2023

El presente artículo forma parte de un proyecto de investigación que lleva por título Ecoestética y tiene como objetivos: 1) hacer una revisión histórica de la relación dominante de la humanidad sobre la naturaleza a partir de los orígenes de la  filosofía moderna; 2) examinar la noción de lucha o competencia entre mundo y tierra en la estética de Martin Heidegger como un planteamiento que se distancia de la riña y de la discordia; 3) observar las características de las obras de arte contemporáneo que se hicieron en el campo abierto planteando nuevas relaciones entre arte y naturaleza a partir del movimiento artístico Land art; 4) comprender las características de las obras de arte que utilizan seres vivos como medio artístico o bioarte; 5)  delimitar el concepto de ecoestética aplicado a obras de arte que establecen una relación armónica con el medio ambiente y no competitiva con la naturaleza para, finalmente; 6) aplicar los conocimientos del presente estudio a la producción artística, dando como resultado la elaboración y emplazamiento de dos instalaciones ecotemáticas elaboradas por los integrantes del Cuerpo Académico Arte y Contexto de la Universidad Autónoma del Estado de Hidalgo en la ciudad de Pachuca, México, en el año 2022.

Para alcanzar los objetivos, la metodología empleada fue la hermenéutica a través de los siguientes pasos: entendimiento y delimitación del problema, recopilación de bibliografía especializada y todo tipo de referencias bibliográficas para su interpretación y análisis, y finalmente,  aplicación de lo comprendido a la producción o creación artística, dando como resultado dos instalaciones in situ: Cama-nido de Julia Caporal y El borde de la modernidad de Miguel Ledezma, co-autores del presente artículo, las cuales se abordan al final.
Cómo hacer cosas con imágenes. Posibilidades educativas de las imágenes desde un enfoque performativo
Authors: Maeso-Broncano Ana , Martínez-Morales María
Published: January 2023

Desde el periodo de entreguerras del s. XX, la imagen sustituye a la palabra como medio dominante para retratar las apariencias, para mostrar lo real (Berger, 2008). Vivimos en un mundo eminentemente visual, en el que recibimos la mayoría de la información por medio de las imágenes. No obstante, avistamos un futuro de incertidumbre, donde la proliferación de imágenes fácilmente puede desembocar en un cansancio de la mirada que conduzca a la inacción. Por ello, se plantea un cambio de paradigma que desplace el foco desde la interpretación o lectura de imágenes hacia la transformación de las realidades desde el uso de las mismas. El siguiente estudio tiene como objetivo repensar las imágenes desde un enfoque performativo, así como explorar sus posibilidades educativas: nos acercamos a los conceptos y teorías fundamentales para entender el término performatividad, desde los estudios de performance y la filosofía del lenguaje. Igualmente, se abordan las teorías en torno a la imagen y sus posibilidades performativas, para valorar, por último, sus aplicaciones en el campo de la educación. Se concibe la imagen como un elemento vivo que genera experiencia al ser producido y percibido: que construye nuestra mirada y nuestros imaginarios, configurados de forma intersubjetiva. Frente a la hegemonía visual actual, se propone entender la creación de imágenes propias como potencias de transformación de las realidades. Esto conforma un objetivo fundamental en una educación que pretende mirar al futuro e incidir en él de manera activa. Se torna esencial generar las bases de un pensamiento crítico en torno a lo visual en el ámbito educativo para transformar realidades: para construir una sociedad más participativa y más justa.
Learning Analytics and Higher Music Education: Perspectives and Challenges
Authors: Lorenzo de Reizábal Margarita , Benito Gómez Manuel
Published: January 2023

Continually monitoring student learning, improving tutoring, predicting academic risks such as performance drops or dropouts, assessing more objectively or understanding the behavior of student groups are some of the tasks that have been beyond the reach of music teachers. The current technology of massive data processing (Big Data) and its analysis (Learning Analytics-LA) allows to achieve these goals with relative ease. The possibility of extracting individual behavior patterns facilitates attention to diversity, reduces school dropout and failure, and opens the possibility of implementing new educational strategies. The phenomenon of data-based education has led to different types of studies. This paper reflects on three trends or fundamental perspectives in the use of the collection of massive information applied to learning and teaching. We offer an overview of research and applications of Learning Analytics specifically in the field of music education, as well as a reflection on its possible practical uses in higher music education in conservatories. For this purpose, we discuss some practical examples of how this technological methodology could be incorporated into music and music education research, and its influence on possible new educational paradigms that lead to innovation on teaching-learning process through new technological resources.
Competition law enforcement in Ukraine: challenges from on-line giants
Authors:   Kyiv National University of Trade and Economics, Gerasymenko Anzhelika , Mazaraki Nataliia ,   Kyiv National University of Trade and Economics
Published: January 2023

Competition law, economics and policy are facing a regulatory metamorphosis due to the rise of the digital economy. US, China and EU jurisdictions have announced and partially introduced systemic changes to their competition law frameworks to keep pace with technological developments. The Antimonopoly Committee of Ukraine is following the principle of ‘three monkeys’, it sees no on-line platforms, hears no on-line platforms, speaks of no on-line platforms, so nothing has been undertaken or even announced. The paper is twofold. Firstly, it analyses the economic background and features of the digital economy and shows why the available instruments of competition enforcement are ineffective. The second part of the paper shows why the current Ukrainian competition law framework is (in)capable of dealing with challenges posed by on-line giants. Regarding the need for a recalibration of regulatory approaches in digital markets, Ukraine faces the dilemma of a proper combination of ex ante and ex post measures.
Sytuacja wykonawców inwestycji energetycznych w związku ze wzrostem cen i utrudnionym dostępem do materiałów budowlanych
Authors:   Wydział Prawa i Administracji Uniwersytetu Łódzkiego, Pater Michał
Published: January 2023

Wzrost cen energii, paliwa, surowców do produkcji, a także rosnąca infl acja, dysproporcja między rosnącym popytem i niewystarczającą podażą oraz koszty związane z transformacją klimatyczną powodują znaczny wzrost cen materiałów budowlanych niezbędnych dla realizacji inwestycji energetycznych. Występujące poważne zaburzenia w łańcuchu dostaw wywierają istotny wpływ, również na dostępność materiałów, co może przyczynić się do dalszych wzrostów cen. W związku z występującymi problemami związanymi ze wzrostem cen oraz ograniczoną dostępnością materiałów budowlanych wykonawcy inwestycji energetycznych stają przed dylematem czy kontynuować realizację nierentownej umowy, narażając się na poniesienie straty, czy zdecydować się na zaprzestanie jej realizacji, przyjmując ryzyko związanych z tym konsekwencji. Kontynuacja nierentownej umowy rodzi pytanie, czy podejmować próbę doprowadzenia do zmiany jej treści w zakresie umożliwiającym zniwelowanie straty, czy też ograniczyć się do dochodzenia roszczeń po zakończeniu umowy na drodze sądowej. Artykuł ma na celu przedstawienie możliwych ścieżek działania wykonawców inwestycji energetycznych w związku z wydłużeniem czasu realizacji umowy bądź wystąpienia straty na skutek wzrostu cen materiałów budowlanych lub braku dostępności materiałów. Przeanalizowana zostanie kwestia potencjalnej zmiany umowy w zakresie wydłużenia czasu realizacji i/lub podwyższenia wynagrodzenia, a także zagadnienie dochodzenia roszczeń wykonawcy w przypadku braku doprowadzenia do zmiany umowy. Przeanalizowana zostanie również kwestia obrony wykonawcy przed ewentualnymi karami umownymi nałożonymi za (wynikłe z ww. okoliczności) brak zrealizowania/nieterminowe zrealizowanie danej umowy
Pojęcie „grupy kapitałowej” w prawie konkurencji a franchising w orzecznictwie sądów administracyjnych
Authors:   Affre i Wspólnicy sp.k., Affre Joanna , Czerwiec Rafał
Published: January 2023

Artykuł przedstawia rozbieżności w rozumieniu franczyzy i grupy kapitałowej na tle prawa konkurencji oraz prawa farmaceutycznego. Organy inspekcji farmaceutycznej uznają czasem, że franczyzobiorca wchodzi w skład grupy kapitałowej franczyzodawcy organizującego sieć aptek. W sytuacji stwierdzenia, że zbyt wiele aptek zostało skupionych w jednej grupie kapitałowej, organy odmawiają wydania zezwolenia na prowadzenie apteki. Skargi na decyzje organów inspekcji farmaceutycznej są rozpoznawane przez wojewódzkie sądy administracyjne, które w niektórych przypadkach uznają, że włączenie franczyzobiorców do grup kapitałowych franczyzodawców było słuszne. Stanowisko, że franczyzobiorca jest częścią grupy kapitałowej franczyzodawcy jest odmienne od przyjętego w przepisach, doktrynie i orzecznictwie prawa konkurencji, gdzie franczyzobiorcę uznaje się za niezależnego przedsiębiorcę, działającego we własnymi imieniu i na własny rachunek. Niezrozumiały jest rozdźwięk w interpretacji, ponieważ przepisy prawa farmaceutycznego nie zawierają własnej defi nicji grupy kapitałowej, lecz odsyłają do defi nicji w ustawie o ochronie konkurencji i konsumentów. Artykuł prezentuje poglądy prawa konkurencji na franczyzę i grupę kapitałową, porównując je z poglądami wyrażanymi w orzecznictwie sądów administracyjnych w ramach prawa farmaceutycznego. Wskazuje na potrzebę systemowej wykładni prawa dla uniknięcia rozbieżności w jego stosowaniu.
Glosa krytyczna do wyroku Wojewódzkiego Sądu Administracyjnego (WSA) w Warszawie z dnia 9 grudnia 2016 r., sygn. akt: VI SA/Wa 721/16 (granica pomiędzy decyzją o wykreśleniu z ewidencji a decyzją o nakazie wstrzymania świadczenia usług hotelarskich)
Authors: Borek Dominik
Published: January 2023

W glosie przytoczono stan faktyczny opisany w wyroku Wojewódzkiego Sądu Administracyjnego (WSA) w Warszawie z dnia 9 grudnia 2016 r., sygn. akt: VI SA/Wa 721/16. Glosowane orzeczenie ma duże znaczenie dla rynku usług hotelarskich w Polsce, dotyczy bowiem postawienia granicy pomiędzy decyzją o wykreśleniu z ewidencji w przypadku niespełniania wymagań ustawowych a decyzją o nakazie wstrzymania świadczenia usług do czasu usunięcia uchybień (Borek, 2021).
Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation
Authors: Colonnetta Megan M , Schedl Paul , Deshpande Girish
Published: January 2023

In Drosophila melanogaster embryos, somatic versus germline identity is the first cell fate decision. Zygotic genome activation (ZGA) orchestrates regionalized gene expression, imparting specific identity on somatic cells. ZGA begins with a minor wave that commences at nuclear cycle (NC)8 under the guidance of chromatin accessibility factors (Zelda, CLAMP, GAF), followed by the major wave during NC14. By contrast, primordial germ cell (PGC) specification requires maternally deposited and posteriorly anchored germline determinants. This is accomplished by a centrosome coordinated release and sequestration of germ plasm during the precocious cellularization of PGCs in NC10. Here, we report a novel requirement for Zelda and CLAMP during the establishment of the germline/soma distinction. When their activity is compromised, PGC determinants are not properly sequestered, and specification is disrupted. Conversely, the spreading of PGC determinants from the posterior pole adversely influences transcription in the neighboring somatic nuclei. These reciprocal aberrations can be correlated with defects in centrosome duplication/separation that are known to induce inappropriate transmission of the germ plasm. Interestingly, consistent with the ability of bone morphogenetic protein (BMP) signaling to influence specification of embryonic PGCs, reduction in the transcript levels of a BMP family ligand, decapentaplegic (dpp), is exacerbated at the posterior pole.
Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain
Authors: Durner Anna , Durner Ellis , Nicke Annette
Published: January 2023

The large intracellular C-terminus of the pro-inflammatory P2X7 ion channel receptor (P2X7R) is associated with diverse P2X7R-specific functions. Cryo-EM structures of the closed and ATP-bound open full-length P2X7R recently identified a membrane-associated anchoring domain, an open-state stabilizing “cap” domain, and a globular “ballast domain” containing GTP/GDP and dinuclear Zn2+-binding sites with unknown functions. To investigate protein dynamics during channel activation, we improved incorporation of the environment-sensitive fluorescent unnatural amino acid L-3-(6-acetylnaphthalen-2-ylamino)–2-aminopropanoic acid (ANAP) into Xenopus laevis oocyte-expressed P2X7Rs and performed voltage clamp fluorometry. While we confirmed predicted conformational changes within the extracellular and the transmembrane domains, only 3 out of 41 mutants containing ANAP in the C-terminal domain resulted in ATP-induced fluorescence changes. We conclude that the ballast domain functions rather independently from the extracellular ATP binding domain and might require activation by additional ligands and/or protein interactions. Novel tools to study these are presented.
Dynamic metabolome profiling uncovers potential TOR signaling genes
Authors: Reichling Stella , Doubleday Peter F , Germade Tomas , Bergmann Ariane , Loewith Robbie , Sauer Uwe , Holbrook-Smith Duncan
Published: January 2023

Although the genetic code of the yeast Saccharomyces cerevisiae was sequenced 25 years ago, the characterization of the roles of genes within it is far from complete. The lack of a complete mapping of functions to genes hampers systematic understanding of the biology of the cell. The advent of high-throughput metabolomics offers a unique approach to uncovering gene function with an attractive combination of cost, robustness, and breadth of applicability. Here, we used flow-injection time-of-flight mass spectrometry to dynamically profile the metabolome of 164 loss-of-function mutants in TOR and receptor or receptor-like genes under a time course of rapamycin treatment, generating a dataset with >7000 metabolomics measurements. In order to provide a resource to the broader community, those data are made available for browsing through an interactive data visualization app hosted at https://rapamycin-yeast.ethz.ch. We demonstrate that dynamic metabolite responses to rapamycin are more informative than steady-state responses when recovering known regulators of TOR signaling, as well as identifying new ones. Deletion of a subset of the novel genes causes phenotypes and proteome responses to rapamycin that further implicate them in TOR signaling. We found that one of these genes, CFF1, was connected to the regulation of pyrimidine biosynthesis through URA10. These results demonstrate the efficacy of the approach for flagging novel potential TOR signaling-related genes and highlight the utility of dynamic perturbations when using functional metabolomics to deliver biological insight.
Savur District’s Republic Period Population Growth And Characteristics
Authors: ARPAĞ Sezin , BAYARTAN Mehmet
Published: January 2023

Çalışmamızda, Güneydoğu Anadolu bölgesinin Dicle bölümünde yer alan ve idari olarak Mardin iline bağlı Savur İlçesi’nin nüfus gelişimi ve özellikleri ortaya konmuştur. Çalışmamızın amacı Savur İlçesi’nde Cumhuriyetin kuruluşundan günümüze
kadar ilçedeki nüfusun değişim seyrini, kır-şehir nüfusunun yıllara göre artış azalışını, nüfus artış hızını ve nüfusun yaş, eğitim ve ekonomik bağımlılık durumu gibi sosyo-ekonomik özelliklerini sayım yapılan yıllara göre ortaya
koymaktır. TÜİK’den alınan nicel verilerle ilçenin demografik yapısı tablo ve grafiklerle görselleştirilip yorumlanmıştır. Çalışmamızda nüfusun tarihsel süreç içerisinde değişimi ve nüfusun nitelikleri üzerinde durularak gelecekte
yapılacak planlamalara ışık tutmak ve ilçenin gelişmesini sağlamak amaçlanmıştır. Savur’da 2020 yılı itibariyle nüfus miktarı 26101’dir. 1950 yılında 40.876 olan nüfus miktarı bu tarihten itibaren azalmıştır. 1953 yılında Savur’a
bağlı Ömerli’ nin ilçe olması nedeniyle nüfus miktarı azalmış ayrıca Mardin-Şırnak-Irak karayolu güzergahının değişmesi ile ilçe eski merkezi konumunu ve stratejik özelliğini kaybetmiştir. 1985 sonrasında yaşanan terör olayları
ve ekonomik faaliyetlerin yetersizliği de büyükşehirlere yapılan göçleri hızlandırmış ve nüfusun azalmasına neden olmuştur. Nüfusun sosyo-ekonomik özellikleri 1985-2020 yılları arasında kıyaslama yapılarak incelenmiştir. 35 yıllık
süreçte nüfusun yaş yapısı incelendiğinde çocuk nüfus oranı %51’den %30’a düşmüştür, yaşlı nüfus oranı ise%4’lerden %10’lara yükselmiştir. Bu durum nüfus artış hızının düştüğünü ve buna bağlı olarak bağımlı nüfusun toplam nüfus
içindeki payının azaldığını göstermektedir. Cinsiyet oranına bakıldığında kadınların sayıca biraz daha fazla olduğu görülmektedir. Eğitim seviyesinde bitirilen eğitim durumuna göre lise ve yükseköğretim mezunlarının sayısının 2020
yılı itibariyle artış gösterdiği belirlenmiştir, okur-yazarlık oranı %40,6’dan %87,6’ya yükselmiştir. Savur’da kırsal nüfus günümüze kadar miktar olarak şehir nüfusunun üzerinde seyretmiştir. Cumhuriyet’in ilk yıllarından günümüze
kadar ilçe nüfus miktarı azalmış fakat nüfusun niteliklerinde olumlu gelişmeler görülmüştür. İlçe nüfusunun artması ve ilçenin daha fazla gelişebilmesi için dışarıya göçün engellenmesi ve özellikle tarım ve turizm alanında var
olan ekonomik potansiyelin girişimlerle desteklenmesi gerekmektedir. Nüfusun değişim seyrini izlemek ve nüfusun nitelikleri hakkında bilgi sahibi olmak ilçenin gelişmesini de sağlayacaktır.
Crisis Experiences and Supporting Resources of Young Adulthood
Authors: ŞAHAN Birsen
Published: January 2023

Bu araştırmada, genç yetişkinlik dönemindeki bireylerin, yaşamları boyunca kendilerini en fazla etkileyen kriz yaşantılarının neler olduğu, bu krizlerle hangi destek kaynaklarını kullanarak baş ettikleri ve herhangi bir profesyonel
yardım alıp almadıkları incelenmiştir. Veriler, 2017-2018 eğitim öğretim yılında bir devlet üniversitesinde pedagojik formasyon eğitimi alan ve yaşları 21 ile 40 arasında değişen 215 genç yetişkin katılımcıdan toplanmıştır. Araştırmada
temel nitel araştırma deseni kullanılmıştır. Katılımcılara yazılı olarak elde edilen veriler, içerik analizi yöntemi ile analiz edilmiş ve temalar oluşturulmuştur. Katılımcılara, krize yol açan olayı, bu olayla baş etmelerini sağlayan
destek kaynaklarını ve profesyonel destek alıp almadıklarını öğrenmeye yönelik açık uçlu sorular sorulmuştur. Katılımcıların büyük çoğunluğu, aile içi olayların (aile üyelerinden birinin ölümü; trafik kazası, yaralanma ya da sağlık
sorunu yaşaması; aile içi gergin olaylar; ebeveynlerin boşanması, kavgaları ya da birbirini aldatması; ihmal ve istismar) kendilerine en acı veren yaşantıları olduğunu belirtmişlerdir. Bunu sırasıyla romantik ilişkilerde, akademik
yaşamda, sosyal ilişkilerde, iş yaşamında, doğal afetler nedeniyle, evcil hayvanıyla olan kriz yaşantıları izlemektedir. Katılımcılar kriz yaşantıları ile kişilik özellikleri, sosyal ilişkileri ve krizin üstesinden gelmek için
gerçekleştirdikleri eylemler yoluyla baş ettiklerini belirtmişlerdir. Katılımcıların kullandıkları en önemli sosyal destek kaynakları aile üyeleridir, en önemli bireysel kaynakları sabırlı olmaktır ve krizle baş etmek için en fazla
yaptıkları şey ise durumu kabullenerek zaman bırakmaktır. Katılımcılardan 22’si yaşadığı krizle baş etmek için profesyonel yardım aldığını belirtmiştir. Krize müdahale aşamasında, danışanlara kendi baş etme becerilerini yeniden
harekete geçirmeleri ve yeni baş etme becerilerini ortaya çıkarmaları konusunda yardımcı olmak gerekmektedir.
Evliya Çelebi's Bursa Travel from the Perspective of Faith Tourism
Authors: YILMAZ Ali İzzet
Published: January 2023

Bu çalışmada, Evliya Çelebi’nin Bursa seyahati, inanç turizmi unsurları açısından incelenmiştir. Evliya Çelebi Seyahatnamesi yolu ile Bursa’nın inanç turizmi açısından taşıdığı öneme ve potansiyele dikkat çekmek hedeflenmiştir. Araştırmada,
nitel araştırma yöntemlerinden doküman incelenmesi yoluyla çalışma yapılmıştır. İncelemede, Yapı Kredi Yayınları tarafından, günümüz Türkçesi ile 2008 yılında yayınlanan Evliya Çelebi Seyahatnamesi’nin ikinci baskısı kullanılmıştır.
Bununla birlikte, farklı yayınevlerince basılan, Evliya Çelebi Seyahatnamesi’nden Seçmeler isimli kitaplar ve bu konuda yapılan diğer çalışmalar da incelenmiştir. Arkadaşı Evliya Çelebi’yi, Osmanlı Padişahlarının Türbelerini ve
diğer nurlu mezarları, özellikle Emir Sultan’ın kabrine yüz sürüp, kalplerini nurla doldurmak önerisiyle Bursa’ya gitmeye ikna etmiştir. Evliya Çelebi’nin bu öneriyi ailesine haber vermeden kabul etmesi, o dönem için bu türbelerin
ziyaret edilmesinin çok önemli olduğunu ve insanları seyahate motive ettiğini göstermektedir. Seyahatnamenin Bursa’da gezilen yerlerinin anlatıldığı bölümünde, Osmanlı Padişahlarının Orhan Gazi’den itibaren seyit soyundan gelmeye
başlamalarını, türbelerin ziyaret etme nedeni olarak belirtilmektedir. Bursa seyahatinde Evliya Çelebi, şehirde bulunan altı Osmanlı padişahının türbesini ziyaret etmiştir. Evliya Çelebi’nin Bursa gezisi sırasında ziyaret ettiği
ve detaylı olarak anlattığı yerlerden ayakta kalanların, günümüzde yerli ve yabancı turistlerin en çok uğradığı yerler olma özelliğini taşıyor olması; şehrin inanç turizmi alanındaki potansiyeline ve söz konusu mekânları kapsayacak
bir inanç turizmi rotası oluşturulmasının faydalı olacağına işaret etmektedir.
“Postmodern” Embedded Journalism As An Ethical Problem
Authors: OĞUZ Cihan
Published: January 2023

İliştirilmiş (embedded) gazetecilik, ilk kez Amerika Birleşik Devletleri’nin 2001 yılında Afganistan’a yaptığı askeri operasyon sırasında uygulanan, ancak gerçek anlamda 2003 yılındaki 2. Körfez Savaşı’nda geliştirilen bir kavramdır.
Aslında önceden de fiilen varlığını sürdürmesine rağmen bu dönemde literatüre yerleşmiştir. Amerikan Savunma Bakanlığı’nın (Pentagon) işgali haklı göstermek ve dünya kamuoyundaki tepkileri önlemek amacıyla, gazetecileri savaş bölgesine
kendi kontrolünde ve denetiminde götürerek, kendi iletmek istediği bilgileri ve görüntüleri servis ettirmesi faaliyetidir. Muhabir ve kameramanlar zırhlı bir araca -çoğunlukla bir tanka- bindirilmekte, çatışmaya katılan askerlerle
birlikte cephede ilerlemektedir. Bir tür “psikolojik harekât” olarak da nitelendirilebilecek bu olgu “basın etiği” açısından irdelendiğinde ise pek çok soru işaretleri doğmaktadır. Bir muhabirin, savaş ya da çatışma bölgesinde
gördüğü ve öğrendiği her şeyi değil de, sadece “görülmesi ve bilinmesi istenen” olayları kamuoyuna iletmesi, gazetecinin asli görevi olan “halkı aydınlatma” işlevi ile çelişki yaratmaktadır. Ama öte yandan, gazetecinin bizzat haberin
içinde olması da mesleki açıdan bulunmaz bir fırsattır. Bu kapsamda embedded gazeteciliğin sadece savaş kavramıyla sınırlı olmadığını da belirmek gerekir. Spor muhabiri haberlerini takip ettiği kulübün, polis muhabiri emniyetin,
belediye muhabiri belediyenin, parlamento muhabiri de takip ettiği siyasi partinin -fanatik veya ılımlı- bir taraftarına dönüşmektedir. Bu bir tür “postmodern” iliştirilmiş gazeteciliktir. Muhabirin “sempati” duygusunu aşan bu
tutumunun izdüşümünde, içinde bulunduğu faaliyetleri iliştirilmiş gazeteciliğe montajlayan ideolojik/kültürel/psikolojik kodlar bulunmaktadır. Muhabir ne kadar tarafsız ve objektif kalmaya çalışırsa çalışsın, bu kodları aşmakta
büyük güçlük çekmektedir. Bu çalışmada, embedded gazetecilik etik bir sorunsal olarak ele alınarak, bu kavramın yaygınlığının savaş/çatışma bölgesi ile sınırlı kalmadığı, medyanın ilgili olduğu neredeyse tüm kritik alanlarda varlığını
sürdürdüğü örneklerle anlatılmış, konu basın etiği açısından eleştirel bir gözle irdelenmiştir.
Social Adaptation Problems of Ahiska Turks’ After Migration to Turkey: The Case of Bursa-Gürsu Disctrict
Authors: ARI Furkan , GÜNGÖR Fethi
Published: January 2023

“Ahıska Türklerinin Türkiye’ye Kabulü ve İskânına Dair Kanun” kapsamı dışında iradi göç ile Türkiye’ye gelen Ahıska Türkleri, serbest göçmen olarak ekonomik, politik ve sosyokültürel uyum sorunlarıyla karşılaşmaktadır. Alanyazında
Ahıska Türklerine yönelik sosyal hizmet müdahale ve politikalarına ilişkin eksikliğin giderilmesi ve bu dezavantajlı kesim adına savunuculuk geliştirilerek farkındalık oluşturulması önem arz etmektedir. Araştırma süreci öncesinde
Yalova Üniversitesi İnsan Araştırmaları Etik Kurulunun 27.07.2021 tarihli 2021/92 sayılı kararıyla izin alınmıştır. Karma araştırma yöntemi ile gerçekleştirilen araştırmanın nicel kısmında 500 Ahıska Türkü serbest göçmene yapılandırılmış
soru formu uygulanmıştır. Araştırmanın hipotezleri “Ahıska Türkü serbest göçmenlerin ülkede kalış süresi arttıkça uyum sorunu azalmaktadır”, “3835 sayılı kanunun sınırlılığından dolayı Ahıska Türkü serbest göçmenlerin sosyal hizmetlere
erişimi kısıtlıdır” ve “Ahıska Türkü serbest göçmenlerin kapalı bir toplum özelliği taşıması göç sonrasında uyum sorunu yaşamalarını engellemektedir” şeklinde belirlenmiştir. Ahıska Türklerinin alanda derlenen uyum sorunları SPSS
26.0 programı kullanılarak frekans dağılımları alınmış olup hipotezler ise ki kare testi ile sınanmıştır. Araştırmanın nitel kısmında ise 13 kurum ve kuruluş yetkilisi ile yüz yüze görüşme yapılarak Ahıska Türkü serbest göçmenlerin
uyum süreçleri ve uyum sorunlarına yönelik cevaplar aranmıştır. Araştırma sonucunda Ahıska Türkü serbest göçmenlerin ekonomik, politik ve sosyokültürel uyum sorunları ortaya konulmuş olup bu uyum sorunlarının çözüme kavuşturulması
için makro sosyal hizmet yaklaşımlarının gerekli olduğu görülmüştür.
Incidentalomas Discovered during COVID- 19 Chest CT Screening: A Cross-sectional Study from Andhra Pradesh, India
Authors: Sandeep Velicheti , Srikanth Vankineni , Sekhar Kondrugunta Chandra , Swetha Balije , Jagadeep Vallabhaneni
Published: January 2023

Introduction: The highly contagious Coronavirus Disease 2019 (COVID-19) virus has spread across the globe. For the aberrant changes in the lung parenchyma, thin-section chest Computed Tomography (CT) is more sensitive than chest radiography and can identify early disease. Increased CT usage and resolution also lead to an increase in the discovery of "incidental" findings, creating questions about additional research, diagnosis, and follow-up with associated financial and emotional costs. Aim: To evaluate the non COVID-19 lung pathologies and other system findings in High Resolution Computed Tomography (HRCT) chest done for COVID-19 screening study. Materials and Methods: This was a cross-sectional study done in the Department of Radiodiagnosis at Dr.Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Vijayawada, Andhra Pradesh, India, from May 2021 to December 2021. The CT scan was done in a craniocaudal direction with an average exposure time of 4-6 seconds, slice thickness of 5 mm and 1.5 mm in mediastinal and lung windows. A total of 1000 HRCT scans done were examined for covid screening. Data was entered in Microsoft Excel and analysed by using Statistical Package for Social Sciences (SPSS) software. Descriptive statistics were represented with percentages. Results: A total of 348 cases were found with various other pathologies incidentally. Lesions like infectious and inflammatory lesions, metabolic diseases, tumours, metastases of various systems and fractures were found. Among 348 total cases with incidental findings 98 cases (28.1%) showed non COVID-19 lung pathologies, 114 cases (32.7%) had findings in the upper abdomen, 30 cases (8.6%) in the thyroid, and three cases (0.8%) had other findings. Conclusion: The HRCT chest screening for COVID-19 not only provided the status of pulmonary infection but gave a broad view of many other system pathologies like in upper abdomen, musculoskeletal system, thyroid, breast which were found incidentally. Identifying those pathologies and correlating them with history will help in early detection and management.
Role of Multidetector Computed Tomography in the Assessment of Olfactory Fossa Depth among the South Indian Population: A Cross-sectional Study
Authors: Kondragunta Chandrasekhara Rao , Kesinakurthi Satish Kumar , Morampudi Satya Chowdary , Gogula Sreeja , Tripuraneni Satish Chandra
Published: January 2023

Introduction: Functional Endoscopic Sinus Surgery (FESS) is one of the most commonly performed surgeries for sinusitis. The olfactory fossa is prone to injury during FESS and the risk of injury depends on the depth of the olfactory fossa. Aim: To assess the depth of the olfactory fossa by multidetector Computed Tomography (CT) and to study the incidence and distribution of asymmetry of olfactory fossa depth. Materials and Methods: A cross-sectional, observational study was conducted at Department of Radiology, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Gannavaram, Andhra Pradesh, India from November 2019 to October 2019. The sample size was 500 patients. All patients above the age of 18 years who were referred to the department of radiology for CT paranasal sinuses were included. Olfactory fossa depth was calculated from the CT scan and statistical analysis was done comparing it with the variables such as age, gender and side of fossa. Results: Out of total 500 participants, 311 (74.2%) patients in the study were males. The mean age of patients was 40.3±16.05 years. There was no significant difference in the olfactory fossa depth on the right side (p-value=0.6) and left side (p-value=0.9) in both genders. A total of 400 (80%) patients of the cases had asymmetry of the olfactory fossa. In males, the most common (n=294, 799.2%) was type 2 Keros on the right and 280 (75.5%) patients on the left side. In females on the right side, type 1 Keros was more common (52 patients, 40.3%) and on the left side type 2 Keros was more common (60 patients, 46.5%) and there was a significant difference in the proportion of different types of Keros in both genders (p-value<0.001). There was no significant difference in the proportion of Keros types among the different age groups (p-value=0.56 on the right side and p-value=0.66 on left side). Conclusion: There was a significant difference in the proportion of Keros types among males and females and the majority of the patients had asymmetry. Prospective studies with intraoperative information from the surgeon can add further information on the utility of the Keros grade.
Umbilical Cord Bilirubin as a Predictor of Neonatal Jaundice in Babies with ABO Blood Group Incompatibility versus without Incompatibility
Authors: Arulparithi Cuddalore Subramanian
Published: January 2023

Introduction: Severe hyperbilirubinaemia cause long-term morbidity that can be prevented by early prediction of the development of significant jaundice by measuring Umbilical Cord Bilirubin (UCB). Aim: To measure the predictability of UCB as an early marker of development of significant hyperbilirubinaemia needing phototherapy. Materials and Methods: The study was a prospective observational study conducted at Vinayaka Mission Medical College, Karaikal, Pondicherry, India. A total of 50 babies born between February and August 2022 were included in the study. Bilirubin levels were obtained at birth by umbilical cord sampling and rechecked again at third or fourth day. Blood group incompatibility was defined as A or B blood group babies born to O group mothers. Phototherapy was started when the bilirubin levels were above or upto 2 mg/ dL below the cut-off for that patient as indicated by the curve for the risk group of the patient as per the American Academy of Paediatrics (AAP) guidelines. Phototherapy also was started if clinically indicated by visual assessment by Kramers rule. Results: Results were analysed by Receiver Operating Characteristics (ROC) curve analysis for measurement of sensitivity and specificity for predicting significant neonatal hyperbilirubinaemia. ROC curve anlaysis revealed that a cutoff of UCB of 1.95 mg/dL resulted in an accepatable sensitivity and specificity for predicting significant jaundice requiring phototherapy at 75% and 68% respectively. ROC curve analysis revealed that Area Under Curve (AUC) for UCB levels of all babies for predicting jaundice requiring treatment was 0.765, 95% CI 0.592 to 0.937. Separate ROC analysis showed that AUC for UCB for predicting phototherapy in babies with blood group incompatibility (AUC 0.80, 95% CI 0.418 to 1.00) was more significant than the AUC for babies without blood group incompatibility (AUC 0.490, 95% CI 0.29 to 0.69). Conclusion: UCB has high predictability for significant jaundice requiring phototherapy. The prediction is more when babies with blood group incompatibility is considered compared to babies without blood group incompatibility.
Xanthogranulomatous Orchitis Mimicking a Testicular Malignancy: A Rare Case with Brief Review of Literature
Authors: Adhlakha Bhuvan , Gogoi Priyanka , Diwaker Preeti , Yadav Priya , Singh Anil
Published: January 2023

Xanthogranulomatous orchitis (XGO) is a rare, distinct type of chronic inflammation causing destruction of the tissue by infiltrate of lipid laden macrophages. It is commonly seen in the gall bladder, kidney and is rarely reported in the testis. Authors hereby, report report a case of a 32-year-old man who presented with a swelling in the right testis since 3 weeks. On clinical examination, ultrasound findings, a provisional diagnosis of testicular neoplasm was made. Simple right orchidectomy was performed and on histopathological examination the testis was found to be replaced with large lipid laden macrophages (Xanthoma cells) along with lymphocytes, foci of necrosis and hemorrhage, a diagnosis of XGO was rendered. The preoperative diagnosis of XGO is very challenging as the condition often mimics a testicular neoplasm, thus the final diagnosis relies on the histopathological examination. Extensive sampling of the tissue should be done to rule out any concurrent testicular neoplasm
Women and Land Tenure in Zambia: Legal and Customary Challenges for Women
Authors: Kalinda Roy , Chirwa Masauso , Thankian Kusanthan
Published: January 2023

Zambia has a dual land tenure system recognized by the constitution and land policy which govern land in all parts of the Country. The Customary system governs the land under the control of traditional leaders while the statutory tenure system governs all land that is titled. In 2021, just before the general presidential and parliamentary elections, a new land policy was launched in Zambia with a 50% provision of land to all women. The new land policy aims at gender equality in land ownership in line with the Southern African Development Community (SADC) and African Union (AU) protocols. This policy has a gender component that deals specifically with the requirement of allocating land to women, the youth and disabled people. Even under statutory land, gender inequalities still remain minimally challenged same despite policy pronouncements which are rarely transformed into political actions intended to deal with gender inequalities in land ownership which is a serious problem among poor women in all the ten provinces.  In all these provinces, women are the minority in terms of land ownership in both urban and rural communities. This situation is compounded by the high poverty levels and illiteracy among both urban and rural women. Provisions of gender equity measures in policies are important steps towards gender equality and should be encouraged all the time and policy reviews should equally take on board emerging issues from time to time. However, the current situation in the country of formulating policies with gender inclusive measures seems to be an end itself because policies are not accompanied by practical programmes aimed at dealing with gender inequalities in different locations and remote communities where the customary tenure system remains unchallenged. Government interventions through land policies have achieved some gains but more would have been achieved if deliberate programmes were instituted on land redistribution especially on statutory land to ensure that the disadvantaged groups even among women benefit from policy changes. Ratification of international conventions that are aimed at combating gender discrimination should be accompanied with practical programmes and policies which should be monitored and evaluated from time to time to ensure that practical progress is made in eliminating gender inequalities in land ownership.
Calculation of the Radius for Any Atom Based on the Planck Constant-free Equation, Mathematical Complexity, and Atomism
Authors: Udema Ikechukwu Iloh
Published: January 2023

Concern has been expressed against the new theories, Heisenberg uncertainty principle (HUP) and Schrödinger wave/quantum mechanics (SE) that are purported to have replaced Bohr’s theory and equation. The research was undertaken with the following objectives: 1) to review concerns about atomism; 2) appraise the issues of mathematical complexities in HUP and SE; 3) review criticism against SE and HUP; 4) most importantly derive a Planck constant invariant equation for the calculation of any atomic radii; and 5) re-calculate the radii of selected elements chosen for their biological importance. The theoretical research with calculations, showed that the opposing theories are criticised because, they are obsessed with mathematical complexities with ambiguities without common ground that should usher alternative solution to the problem of the size of atom and thus, they cannot be considered as a valid description of reality. Bohr’s equation and variants of it and the Planck constant invariant equation (Eq. (15)) derived in this research are regarded as deterministic in nature and were capable of reproducing Bohr’s radii for any atom; the radii were also capable of reproducing the average ionisation energies of hydrogen and oxygen atoms, chosen for illustration only, when substituted into derived preliminary equation (Eq. (10)).
Hepatocellular Carcinoma & Hypoxia: A Review
Authors: Elborei Mohamed
Published: January 2023

Liver is the largest gland inside our body, and it is accounted for many functions in the body but like any other organ in the body it is prone to different disease but the most dangerous one of them is hepatocellular carcinoma. Hepatocellular carcinoma is fetal, and it is having low survival rate and it is resistant to the most of the know therapy that’s why there is always a need for new treatment modalities. It has different causative agents, different staging methods, different mechanism for hepatocarcinogenesis and different treatment modalities like liver resection, liver transplantation and sorafenib. Tumor hypoxia is a common feature of hepatocellular carcinoma and other solid tumours, and it results from a lack of blood supply to the rapidly expanding cancer cells. Tumor hypoxia is an unfavourable prognosis factor since it enhances the tumor's aggressiveness and resistance to treatment, which is why reducing tumour hypoxia has a lot of therapeutic benefits for cancer patients. Drug resistance, metastasis, angiogenesis, metabolic shifting, radiotherapy resistance, and overall tumour aggressiveness and poor prognosis are all caused by hypoxia inducible factor 1, which causes drug resistance, metastasis, angiogenesis, metabolic shifting, radiotherapy resistance, and overall tumour aggressiveness and poor prognosis. There is keen research working on the tumor hypoxia and trying to discover new drugs and approaches to correct the tumor hypoxia like prodrugs activated by hypoxia, hyperbaric oxygen, nanoparticles, oral oxygen therapy and finally hypoxia inducible factors inhibitors like for example benzopyranyl 1,2,3-triazole, glyceollins and vorinostat.
Patient-reported perceptions of brexanolone in the treatment of postpartum depression: A qualitative analysis
Authors: Salwan Aaron , Maroney Megan , Tremayne Lisa
Published: January 2023

Introduction

Brexanolone demonstrates short-term efficacy for the treatment of postpartum depression (PPD). Postpartum depression is linked to infanticide and maternal suicide, and current treatment often fails to adequately control depressive symptoms. The purpose of this analysis is to further understand the experience(s) of women who have received brexanolone for the treatment of PPD.

Methods

Semistructured interviews modeled after the theory of planned behavior (TPB) were conducted to assess women's perceptions of treatment for PPD with brexanolone. Women who received treatment with brexanolone at this inpatient facility were eligible to participate in this study. The TPB is often used to predict intention to perform health-related behaviors. Semistructured interviews were recorded and transcribed, and thematic analysis was conducted to identify common ideas across all interviews. Follow-up assessment of depressive and anxious symptoms was also conducted using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7), respectively.

Results

Five of the 10 women who received treatment with brexanolone at this facility were interviewed, and common themes related to the TPB were analyzed. Attitudes toward brexanolone were favorable, and having a strong support system was a motivating factor in receiving treatment for PPD. Insurance approval, need for childcare, and poor understanding of symptoms of PPD were barriers to receiving treatment with brexanolone. Symptoms of depression and anxiety were rated as low at the time of the follow-up interview as measured by the PHQ-9 (mean 1.6, range 1 to 3) and GAD-7 (mean 2.8, range 2 to 4), respectively.

Discussion

Brexanolone rapidly and sustainably reduced symptoms of PPD and was well-received by patients. Despite significant barriers to use, women who received treatment with brexanolone advocated for its availability as well as increased awareness of PPD.
Treatment of concurrent etizolam and tianeptine withdrawal following accidental overdose
Authors: Markovic Marija , Niwash Dania
Published: January 2023

Background

The availability of nonapproved psychoactive substances with addiction potential from internet sources poses a significant threat to public health. Polysubstance abuse or inadvertent contamination of preparations may result in clinically challenging intoxication and withdrawal syndromes.

Case Report

We report a case of a 32-year-old male with an approximate 2-year history of taking internet-obtained etizolam and tianeptine who presented to the hospital following an overdose. He experienced subsequent withdrawal symptoms consistent with benzodiazepine and opioid withdrawal. Initial attempts at managing symptoms with chlordiazepoxide 25 mg every 6 hours did not relieve his symptoms. On day 3 of admission, addiction medicine was consulted and his regimen was changed to diazepam 80 mg daily with additional as-needed diazepam based on etizolam equivalence. He also received a 5-day methadone taper with plans to transition to buprenorphine in the outpatient setting. Upon discharge he was referred to an addiction medicine specialist who was willing to continue a slow diazepam taper and initiate medications for opioid use disorder to manage both substance use disorders.

Discussion

This case report demonstrates the effectiveness of diazepam in managing benzodiazepine withdrawal from etizolam while concurrently using methadone to manage opioid withdrawal symptoms from tianeptine in a hospitalized patient following overdose. We highlight the importance of a warm handoff in considering the outpatient discharge plan.
Impacto da meningite entre os anos de 2010 a 2020 no Brasil
Authors: Fernandes Queiroga Moraes Gustavo , Atanael Oliveira Galdino Mateus , Paula de Castro Teixeira Anna
Published: January 2023

Introdução: a meningite é uma infecção que afeta as membranas as quais revestem o encéfalo e a medula espinhal, sendo incluída na Lista Nacional de Doenças de Notificação Compulsória. Objetivo: investigar o perfil epidemiológico de acometidos por meningite noBrasil, entre os anos de 2010 a 2020. Metodologia: trata-se de um estudo epidemiológico, retrospectivo, analítico e documental, pelo qual as informações acerca dos casos confirmados no Brasil foram extraídas através do Departamento de Informática do Sistema Único de Saúde (DATASUS). Para análise estatística foi utilizado o software Statistical Package for Social Sciences (versão 20.0). Resultados: no período analisado, foram notificados 187.508 casos de meningite, sendo 2012 o ano com maior número de casos (11,6%). A região que apresentou o maior número de mortes foi sudeste (54,2%), possuindo São Paulo como o estado de maior número de notificações (41%). O perfil foi composto, predominantemente, por indivíduos do gênero masculino (59,1%), com faixa etária entre ≤1 a 9 anos (47%) e etiologia viral (45,5%). O método quimiocitológico foi o mais utilizado (60,9%), o qual os enfermos evoluíam a alta (75,8%). Além disso, a meningite bacteriana apresentou a maior taxa de mortalidade (1,8/100.000 habitantes), enquanto a meningococcemia a maior taxa de letalidade (36,7%). Houve associação estatística positiva entre as variáveis: número de óbitos e faixa etária, número de óbitos e gênero e, número de óbitos e etiologia. Conclusão: é essencial a adoção de políticas públicas com escopo às populações de risco, sendo esse estudo, profícuo na construção de tais projetos.
Mielopatia ou paraparesia espástica tropical (HAM/TSP) e os domínios da SF-36
Authors: Ramos Daniela Sena , Conceição Cristiano Sena da , Ribeiro Nildo Manoel da Silva
Published: January 2023

Introdução: a paraparesia espástica tropical ou mielopatia associada ao HTLV (HAM/TSP) é umadoença infecciosa e inflamatória crônica, que pode interferir em vários aspectos da vida do indivíduo e, com isso, alterar sua qualidade de vida (QV). Objetivo: avaliar os domínios da escala SF-36 que mais contribuem para as alterações na qualidade de vida dos pacientes com HAM/TSP. Metodologia: nesse estudo observacional, transversal e quantitativo, realizado com 49 pacientes diagnosticados com HAM/TSP do setor de Neurociências do Ambulatório Professor Francisco Magalhães Neto, na cidade de Salvador, Bahia, Brasil, a qualidade de vida foi avaliada pelo questionário de saúde Short Form-36 (SF-36), no período de fevereiro de 2019 a julho de 2020, e de fevereiro de 2022 a abril de 2022. Os dados obtidos foram avaliados por análise estatística descritiva e testes de correlação de Pearson e Spearman. Resultados: foi observado que os menores escores do questionário SF-36, indicando pior qualidade de vida, foram relativos aos domínios vinculados às limitações físicas, capacidades funcionais e limitações emocionais, nessa ordem. Os melhores domínios, indicando melhor qualidade de vida, nessa população, foram saúde mental e aspectos sociais, demostrando que os pacientes com HAM/TSP relatam alterações físicas e emocionais em sua qualidade de vida. Conclusão: os domínios que mais alteraram a qualidade de vida dos pacientes com HAM/ TSP foram AF, CF e AE. Assim, utilizando-se da escala SF-36, profissionais de saúde podem identificar e intervir precocemente em domínios que comprometam a saúde física e emocional dos pacientes com HAM/TSP, alterando, consequentemente, sua qualidade de vida.