bluuebunny/crossref_metadata_2025 huggingface dataset:
Skrining Senyawa Aloesin Pada Lidah Buaya (Aloe vera (L.) Burm.f.) sebagai Antikanker Prostat Secara In Silico
Authors: Ni Luh Putu Cintya Pramesti  , Ni Putu Linda Laksmiani
Published: June 2023

Kanker prostat merupakan tumor ganas yang menempati urutan kelima jumlah penderita terbanyak pada pria di Indonesial. Salah satu penyebab terjadinya kanker prostat yaitu adanya ekspresi berlebih dari reseptor androgen yang meregulasi poliferasi sel kanker prostat pada kelenjar prostat. Tumbuhan lidah buaya (Aloe vera (L.) Burm.f.) diduga memiliki aktivitas sebagai antikanker. Salah satu senyawa yang terdapat di dalam tumbuhan lidah buaya dalam jumlah besar adalah aloesin. Tujuan dari penelitian ini adalah untuk mengetahui potensi senyawa aloesin dari lidah buaya sebagai antikanker prostat terhadap reseptor androgen menggunakan metode molecular docking secara in silico. Pengujian dilakukan dalam beberapa tahapan meliputi penyiapan database struktur 3D senyawa aloesin (CID: 160190) serta reseptor androgen (PDB ID: 3b67), preparasi serta optimasi aloesin menggunakan Hyperchem 8, preparasi reseptor androgen menggunakan Chimera 1.11.1, validasi metode molecular docking dan docking senyawa aloesin dilakukan dengan menggunakan aplikasi AutoDockTools 1.5.6. Hasil penelitian menunjukkan bahwa metode molecular docking menunjukkan hasil validasi yang valid karena nilai RMSD yang dihasilkan sebesar 0,62 Å (≤ 2 Å). Hasil docking menunjukkan nilai energi ikatan native ligand dengan reseptor androgen adalah sebesar -9,11 kkal/mol sedangkan nilai energi ikatan senyawa aloesin dengan reseptor androgen sebagai protein target adalah sebesar -10,68 kkal/mol. Hasil tersebut menunjukkan bahwa senyawa aloesin yang terkandung dalam tumbuhan lidah buaya memiliki afinitas sebagai inhibitor lebih kuat dan stabil terhadap protein target yaitu reseptor androgen dibandingkan dengan native ligandnya dengan nilai energi ikatan yang lebih negatif, sehingga diketahui bahwa senyawa aloesin memiliki potensi sebagai antikanker prostat secara in silico melalui penghambatan reseptor androgen.
Studi Potensi Senyawa Hidrangenol dan Asam Hidrangeat dari Daun Hydrangea macrophylla sebagai Bahan Utama Aktif Khasiat Jamu Antidiabetes
Authors: Ayu Pradnya Paramita
Published: June 2023

Diabetes mellitus merupakan salah satu penyakit metabolik yang menyebabkan tingginya angka mortalitas di dunia dan di Indonesia secara khususnya. Terapi farmakologi yang dilakukan untuk penyakit diabetes mellitus selama ini umumnya menggunakan obat-obatan antidiabetes oral seperti metformin dan obat-obatan antidiabetes injeksi seperti insulin. Namun seiring berkembangnya konsep back to nature, banyak penelitian yang dilakukan untuk mengetahui aktivitas antidiabetes pada senyawa bahan alam salah satunya pada tanaman kembang bokor (Hydrangea macrophylla). Artikel ini ditujukan mengetahui aktivitas antidiabetik senyawa hidrangenol (hydrangenol) dan asam hidrangeat (hydrangeic acid) dari daun Hydrangea macrophylla sebagai bahan aktif utama khasiat produk jamu antidiabetes. Pemaparan mengenai potensi daun Hydrangea macrophylla sebagai bahan utama aktif khasiat jamu antidiabetes disusun dengan menggunakan metode review artikel. Hasil menunjukkan bahwa senyawa hidrangenol dan asam hidrangeat memiliki aktivitas antidiabetes dengan mekanisme peningkatan absorpsi 2-deoksiglukosa ke dalam sel, peningkatan translokasi GLUT4 ke dalam membran plasma, dan peningkatan pelepasan hormon adiponektin yang bertanggung jawab atas terjadinya resistensi insulin yang terjadi terutama pada penderita diabetes mellitus tipe 2. Kombinasi antara hidrangenol dan asam hidrangeat menjadikan daun Hydrangea macrophylla memiliki potensi yang besar sebagai bahan aktif utama khasiat (BAUK) produk jamu antidiabetes. Selain itu, dengan adanya phyllodulcin pada daun Hydrangea macrophylla juga menjadi keuntungan dari segi rasa jamu antidiabetes. Rasa manis yang berasal dari senyawa phyllodulcin dapat dijadikan solusi produk jamu antidiabetes tanpa penambahan gula berlebih sehingga tidak mengurangi khasiat dari bahan aktif utama.
The Potential Benefits of Hypertension Management Watches
Authors: Wise Jacob
Published: June 2023

Hypertension is a described as a “silent killer.” The condition is characterized by a clinically significant increase in the force that the blood exerts on the blood vessel walls and is diagnosed when a patient has a blood pressure of above 130/80 mmHg compared to a normal blood pressure of around 120/80 mmHg (Jiang et al., 2016). Hypertension is oftentimes not associated with any symptoms, allowing it to impact the health of millions of people across the world without them knowing (Jiang et al., 2016). Although an individual’s blood pressure typically rises as they grow older, hypertension can affect people of all ages and does not only impact older adults. There are many methods for measuring blood pressure and each approach has its own benefits and weaknesses. Personally, I was diagnosed with primary hypertension at a young age. Primary hypertension, sometimes referred to as essential hypertension, is defined as abnormally high blood pressure with no known cause (Lockett, 2021). As such, at an older age, my avatar will continue to manage this same health issue that I currently face. I have used many different blood pressure monitoring devices and have had issues with all of them. This lack of a suitable technology that can constantly monitor my blood pressure in an accurate, inconspicuous, and inexpensive way inspired me to investigate the potential benefits of a wearable blood pressure watch which also administers antihypertensive medication, like an insulin pump. Hypertension management watches have the potential to improve the arduous process of blood pressure control for patients while resolving current disparities in human healthcare.
Older adults in a Modern World
Authors: Carver L.F.
Published: June 2023

Editorial
Older adults in a Modern WorldBy L.F. Carver, Editor-in-Chief
Stereotypes that suggest older adults are resistant to technology may have had some accuracy in the 1980s but are now outdated and inaccurate. Technology has been evolving quickly over the past century, and older adults have been adapting to these changes just as quickly. Telephones went from a single wall mounted phone in the home to cordless handsets and cellphones, changes driven by the buying habits of people who are now older adults. The consumers who enthusiastically embraced home computers, then laptops and finally tablets are now middle aged or older adults.(Geron)technologies are those technologies that support aging adults – but these do not need to be limited to health-related devices. Older adults generally report feeling much younger inside than their chronological age and buy technology that supports them to engage in hobbies and activities that they did in their twenties and thirties. These technologies often mirror those chosen by their younger counterparts.Governments are recognizing the importance of AgeTech with investments in the development of these industries. For example, in late 2022/early 2023 the Canadian government announced a $47 million dollar investment (via the Strategic Innovation Fund) and the American National Institute on Aging (a2 Pilot Awards) unveiled $40 million for AgeTech over five years. Given the inaccuracies of traditional ageist stereotypes it is important to avoid surveillance and communal residential settings (e.g., long term care homes) as the focus for AgeTech, especially given most older adults are uninterested in living these facilities and technology that violates their privacy.Modern older adults are interested in technologies that enable them maintain independence, aging gracefully in place, in their own homes. However, they tend to reject technologies that impinge on privacy – especially those that involve 24/7 surveillance. Ambient assisted living, which generally involves cameras and pressure plates that record, and report, movement and activity are a favourite among caregivers and concerned family but are generally repudiated by older adults.Finally, older adults who refuse certain technologies are not ‘resistant’ to tech, they just don’t want technology to try to fool them or replace reality. If they enjoy travel, they want technology that allows them to continue to travel as long as possible, not virtual reality goggles. Older animal lovers don’t want a robot pet, they want technology to support them to continue to care for their non-human companions as long as possible.The most important thing for policy makers, technology companies and younger adults to remember is that older adults share many of the same consumer interests when it comes to technology as younger adults. In fact, instead of considering older adults as something different or ‘other’ than their younger counterparts, we need to remember that they are the same people as they were when they were younger, they just have more mileage.
EFEK TIME HISTORY BANGUNAN GEDUNG TERHADAP FONDASI TIANG PADA TANAH LUNAK YANG BERLOKASI DI TANGERANG
Authors: Gabriella Jessica , Wijaya Hendy , Yuwono Amelia
Published: June 2023

Indonesia is an earthquake prone area, because its is a located the confluence of three tectonic plates of the world’s. Earthquake is a rock event in the earth’s crust that releases energy suddenly and can result in loss of life and other damage. Therefore, it is necessary to take steps to reduce of prevent loss of live and other damage bye the analyzing of the earthquake impact on the analyses that can be used. Time history analysis is a method to determine the movement of a structure by providing a record of the earthquake, this method requires several earthquake recordings and was carried out with the help on the Midas Gen program. Required data such as superstructure modelling, soil parameters, and pile bearing capacity are entered into the program. After that, the program will generate displacemenet and reaction forces, which will be analyzed from each earthquake record.
Abstrak
Indonesia merupakan daerah yang berpotensi gempa karena berada pertemuan tiga lempeng tektonik dunia. Gempa bumi merupakan peristiwa batuan pada kerak bumi yang melepaskan sejumlah energi secara tiba-tiba dan dapat mengakibatkan korban jiwa dan kerusakan lainnya. Maka dari itu dibutuhkan langkah – langkah untuk mengurangi dan mencegah terjadinya korban jiwa dan kerusakan lainnya, dengan menganalisis efek gempa terhadap kestabilan fondasi pada bangunan. Salah satu analisis yang dapat digunakan adalah analisis riwayat waktu. Analisis riwayat waktu adalah salah satu metode untuk mengetahui pergerakan struktur dengan cara pemberian suatu rekaman gempa terhadap model tersebut. Analisis riwayat waktu ini dilakukan dengan program Midas GEN. Metode ini membutuhkan beberapa rekaman gempa.  Data yang diperlukan seperti pemodelan stuktur atas, parameter tanah, daya dukung tiang dimasukan kedalam program. Selanjutnya program akan menghasilkan deformasi dan gaya reaksi yang akan dianalisis dari masing masing rekaman gempa.
METODE PERBAIKAN TANAH DENGAN PREFABRICATED VERTICAL DRAIN (PVD) PADA JALAN TOL SERPONG-BALARAJA SEKSI 1B
Authors: Shendy  , Sandjaja Gregorius
Published: June 2023

On the Serpong-Balaraja Toll Road Section 1B there are soft slopes on some of these roads. This soft material has the potential to damage construction due to its high compressibility and low bearing capacity. An alternative soil improvement that will be carried out to overcome this soft soil is to use a Prefabricated Vertical Drain (PVD) to accelerate the settlement that will occur. This PVD can accelerate settlement by shortening the flow of water to the surface. The soft soil considered in this project is located at a depth of 8 m for zone 1 and 10 m for zone 2. The calculation results obtained in zone 1 when loaded by a 2,694 m high embankment is 88,6724 mm and for zone 2 with an embankment load as high as 5.385 m is 162,3204 mm. The PVD method will be installed using a triangular pattern with a distance of 1,25 m which can produce a 90% degree of consolidation within 25 weeks or 181 days taking into account the consolidation time with the PVD in accordance with existing monitoring.
Abstrak
Pada Jalan Tol Serpong-Balaraja Seksi 1B terdapat tanah lunak pada sebagian jalan tersebut. Tanak lunak ini memiliki potensi untuk merusak konstruksi dikarenakan kompresibilitas tinggi dan daya dukung rendah. Alternatif perbaikan tanah yang akan dilakukan untuk mengatasi tanah lunak ini adalah dengan menggunakan prefabricated vertical drain (PVD) untuk mempercepat penurunan yang akan terjadi. PVD ini dapat mempercepat penurunan dengan memperpendek aliran air ke permukaan. Tanah lunak yang ditinjau pada proyek ini terletak pada kedalaman 8 m untuk zona 1 dan 10 m untuk zona 2. Hasil perhitungan yang didapatkan pada zona 1 apabila dibebani oleh timbunan setinggi 2,694 m adalah sebesar 88,6724 mm dan untuk zona 2 dengan beban timbunan setinggi 5,385 m adalah sebesar 162,3204 mm. Metode PVD yang akan dipasang menggunakan pola segitiga berjarak 1,25 m yang dapat menghasilkan derajat konsolidasi 90% dalam waktu 25 minggu atau 181 hari dengan memperhatikan waktu konsolidasi dengan PVD sesuai dengan monitoring yang ada.
KAJIAN PENGARUH RISE-SPAN RATIO PADA JEMBATAN TIED ARCH
Authors: Songbes Eko Felix , Suangga Made , Leman Sunarjo
Published: June 2023

The economic growth of a region in Indonesia is strongly influenced by road and bridge infrastructure. The problem is to design the optimal configuration of the rise-span ratio of the tied arch bridge. This problem must be studied further due to the maximum load combination according to SNI 1725:2016 and SNI 2833:2016. This study aims to understand the effect of rise-span ratio on deformation, natural frequency, magnitude of seismic forces, internal forces and optimum rise-span ratio on a tied arch bridge. This is based on previous research that neglecting the rise-span ratio affects the behavior of the structure as a whole, this needs to be studied according to the location where the bridge is built, because there is an influence from the seismic force response spectrum. The loading given is in accordance with SNI 1725:2016 and SNI 2833:2016. Modeling and structural analysis using Midas Civil software. The rise-span ratio (f/L) used is 1:10.00, 1:8.00, 1:5.71, 1:4.44, 1:3.64, 1:3.07, 1:2.67, 1:2.35, 1:2.09, 1:2.00, the length (L) of the tied arch bridge is 60 meters. The effect of the rise-span ratio on deformation is directly proportional, while the compressive axial force on the acrh rib is inversely proportional.
Abstrak
Pertumbuhan ekonomi suatu daerah di Indonesia sangat dipengaruhi oleh infrastruktur jalan dan jembatan. Adapun permasalahannya adalah merancang konfigurasi rise-span ratio jembatan tied arch optimum. Permasalahan ini harus dikaji lebih lanjut akibat kombinasi beban maksimum sesuai SNI 1725:2016 dan SNI 2833:2016. Studi ini bertujuan untuk memahami pengaruh rise-span ratio terhadap deformasi, frekuensi alami, besarnya gaya gempa, gaya-gaya dalam dan rise-span ratio optimum pada jembatan tied arch. Hal ini didasari pada penelitian terdahulu bahwa pengabaian rise-span ratio berpengaruh pada perilaku struktur secara keseluruhan, ini perlu dikaji sesuai dengan letak jembatan tersebut dibangun, karena ada pengaruh dari gaya gempa respons spektrum . Pembebanan yang diberikan sesuai dengan SNI 1725:2016 dan SNI 2833:2016. Pemodelan dan analisis struktur menggunakan software Midas Civil. Rise-span ratio (f/L) digunakan adalah 1:10,00, 1:8,00, 1:5,71, 1:4,44, 1:3,64, 1:3,07, 1:2,67, 1:2,35, 1:2,09, 1:2,00, panjang (L) jembatan tied arch adalah 60 meter. Pengaruh rise-span ratio terhadap deformasi adalah  berbanding lurus, sedangkan gaya aksial tekan pada acrh rib adalah berbanding terbalik.
PENGARUH SEMANGAT KERJA TERHADAP PROGRESS PADA PROYEK GUDANG SURYA GRAND CISOKA
Authors: Chandra Carlos , Kushartomo Widodo
Published: June 2023

The spirit at work is is a very important aspect in carrying out a construction activity. This morale can affect the length of time it takes to work on a project, if the lower the morale of the workers, the longer it will take to carry out the development project. This work spirit is closely related to the time spent on a construction project. This study aims to determine the effect of morale on the progress of project realization. This type of research uses data collection techniques carried out using observation and interviews conducted through question and answer between researchers and informants. The population in this study were workers who worked in the Surya Grand Cisoka warehouse development project and the samples taken for this study were 6 workers. The results of the case studies show that the morale of the workers has an important role or a very significant contribution to the progress of the realization of project development. The results of this study indicate that on average the morale of workers decreases because their wages are late for days.
Abstrak
Semangat kerja merupakan aspek yang sangat penting didalam menjalani sebuah kegiatan konstruksi. Semangat kerja ini dapat mempengaruhi lama waktu pengerjaan suatu proyek. Semakin rendah semangat kerja para pekerja maka semakin lama juga waktu yang dibutuhkan dalam melakukan proyek pembangunan tersebut. Semangat kerja ini sangat berkaitan dengan waktu pengerjaan sebuah proyek konstruksi. Penelitian ini bertujuan untuk mengetahui pengaruh semangat kerja pada progress realisasi proyek. Teknik pengumpulan data dilakukan menggunakan observasi dan wawancara antara peneliti dan narasumber. Populasi dalam penelitian ini adalah para pekerja yang bekerja di proyek pembangunan gudang Surya Grand Cisoka dan sampel yang diambil untuk penelitian ini sebanyak 6 orang pekerja. Hasil studi kasus menunjukan bahwa semangat kerja para pekerja mempunyai peran penting atau kontribusi yang sangat berarti bagi progress realisasi pembangunan proyek. Dari hasil penelitian ini menunjukan bahwa rata rata semangat pekerja menurun karena upah mereka yang telat berhari-hari.
Specific injury scenarios due to ‘victims’ own negligence’ among Federal Fire Service officers and workers of the EMERCOM of Russia
Authors: Kondashov A. A. , Bobrinev E. V. , Udavtsova E. Yu.
Published: June 2023

Relevance. Victims’ own negligence is a main cause of injuries among the EMERCOM of Russia officers.

The objective is to analyze occupational injury scenarios caused by ‘victims’ own negligence’ among the Federal Fire Service (FFS) officers and workers of the EMERCOM of Russia within 2010 to 2021 timespan.

Methods. The study examined 10,000 fire service officers to analyze the incidence of occupational injuries due to ‘victims’ own negligence within 2010 to 2021, depending on the injury-associated activity, patient’s position, age, type of injury, weekday and month of injury. We calculated arithmetic average values and errors (M ± m). By knowing the number of injuries and the number of fire service officers at risk, we calculated the risks of injury for specific occupational scenarios.

Results and discussion. The FFS officers of the EMERCOM of Russia are subject to the average annual risk of injury due to victims’ own negligence of (4.49 ± 0.62) ∙ 10–4 injuries / (person ∙ year). The risk of injuries commissioned officers (5.54 ± 0.87) ∙ 10–4 injuries/(person ∙ year) exceeds that among non-commissioned workers (3,14 ± 0,29) ∙ 10–4 (injuries/person ∙ year). Over 12 years, the incidence of injuries saw a 2.7-fold decrease among commissioned officers and a 1.4-fold decrease among non-commissioned workers. The share of injuries due to ‘victims’ own negligence’ stood at 36 % of the total number of occupational injuries among fire service officers.

Conclusion. The analysis of injury scenarios due to ‘victims’ own negligence’ among the FFS officers of the EMERCOM of Russia is a contribution to enhance prevention of occupational injuries among firefighters and reduce the death rate in occupational settings.
Multirobot Navigation Using Partially Observable Markov Decision Processes with Belief-Based Rewards
Authors: Tzikas Alexandros E. , Knowles Derek , Gao Grace X. , Kochenderfer Mykel J.
Published: June 2023

For the safe deployment of multirobot systems, accurate position estimation is necessary. We present a multirobot navigation algorithm that accomplishes the dual objective of reaching designated goal positions and maintaining low position uncertainty. We pose the problem as a [Formula: see text]-partially observable Markov decision process ([Formula: see text]POMDP) to capture position uncertainty through a belief-based reward. The multirobot system employs a centralized extended Kalman filter (EKF) for state estimation, whose output is used as the observation as well as the belief in the [Formula: see text]POMDP. Using the EKF output as the observation and belief allows for the integration of the EKF in the action planning module of the system. To solve the [Formula: see text]POMDP, we adapt the online information particle filter tree algorithm to be compatible with the EKF closed-form output being used as both the observation and belief. We present results for the proposed navigation algorithm that show emergent behaviors for a multirobot system, where the robots move to provide inter-ranging measurements that minimize position uncertainty for all robots in the system. We also demonstrate that the proposed method outperforms a state-of-the-art solver (partially observable Monte Carlo planning with observation widening) and a direct-to-goal planner in terms of minimizing position uncertainty.
Data-Driven Approach Toward Airspace Design for Regional Air Mobility Operations in Korea
Authors: Kim Junghyun , Kim Seulki
Published: June 2023

As the Korean government agencies have recently announced the first official road map for urban air mobility (UAM) with the aim of introducing a new aviation transportation system, many companies in South Korea have initiated projects to design airspace infrastructure for UAM operations at the early stage of development. Given that the agencies tentatively plan to expand UAM to regional air mobility (RAM) operations at the mature stage of development, this research specifically focuses on establishing airspace infrastructure for upcoming RAM operations in South Korea. The proposed methodology leverages three different algorithms: 1) a partitioning-based clustering algorithm for placing vertiport locations, 2) a density-based clustering algorithm for predicting areas of convective weather, and 3) the Latin hypercube sampling-based probabilistic road map (LHS-based PRM) algorithm for generating an adaptive airspace network. The resulting airspace, constructed by the proposed methodology, takes into account airspace restriction areas such as prohibited areas or military operation areas. The main contribution of this research is to employ a data-driven approach using machine learning and LHS-based PRM algorithms to dynamically establish airspace infrastructure to be potentially used for upcoming RAM operations in South Korea.
Acoustic Modeling Using the Aeroacoustic Wave Equation Based on Pierce’s Operator
Authors: Schoder Stefan , Spieser Étienne , Vincent Hugo , Bogey Christophe , Bailly Christophe
Published: June 2023

The capabilities of an aeroacoustic wave equation based on Pierce’s operator (AWE-PO) for modeling subsonic flow-induced sound and for sound prediction are investigated. The wave equation is applied to an isothermal two-dimensional mixing layer computed by direct numerical simulation. In contrast to a direct numerical simulation, providing the acoustic fluctuations directly, the simulations based on Lighthill’s wave equation and the AWE-PO rely on a hybrid workflow to predict the generated sound field. Special attention is put on the interpretation of the right-hand side of both wave equations. Comparing the terms on the right-hand side in Lighthill’s theory and AWE-PO suggests a source amplitude for AWE-PO that is 90% smaller. This reduction is attributed to the filtering property of the material derivative. Finally, the results of the acoustic far-field pressure are compared. It is shown that the radiated sound field’s directivity, propagation, and convection effects are well captured for both wave equations. The computations using Lighthill’s equation and AWE-PO are found to provide acoustic intensities within 1.8 dB from the reference direct numerical simulation. This error is comparable with the errors reported for Lighthill’s equation in previous studies.
Inertial Stable Platforms for Precision Pointing of Optical Systems in Aerospace Applications
Authors: Negro James , Griffin Steven F. , Kelchner Bryan L. , Beazel Victor
Published: June 2023

Both airborne and space-based high-energy laser weapon systems present interesting challenges for precision line-of-sight control. Sub-microradian to microradian pointing accuracies are required against dynamic targets. In addition, “absolute” pointing and accurate inertial angular rate measurement are required to support mission requirements. This paper addresses these unique directed-energy weapon (DEW) precision-pointing requirements and their associated implementation alternatives in the context of strapdown and stable platform inertial reference technologies. The contributions of this paper consider the broader issues of DEW requirement drivers, integration of the stabilization system with the rest of the optical system, and design tradeoffs between stable platform and strapdown stabilization mechanizations. Both types of mechanisms are mounted to the gimbal of an imaging system using gryo sensors (gyros) and accelerometers to maintain a desired orientation in inertial space independent of the craft motion. Although both can include an optical reference that propagates through the optical path for optical alignment and jitter control, only in the stable platform is the optical reference stabilized. When combined on the same platform with a stabilized inertial measurement system and closed-loop stabilization with the optical reference, the mechanism becomes a stabilized inertial reference unit, which provides a stabilized optical reference to the electro-optical/laser pointing and jitter control systems.
QUO VADIS PEMILU SERENTAK? (Studi Tentang Pemungutan dan Penghitungan Suara Pada Pemilu Serentak 2019 di Kota Balikpapan)
Authors: Dian Isfiana  , I Ketut Gunawan  , Muhammad Hairul Saleh
Published: June 2023

Penelitian ini menyoroti Pilkada serentak 2019 di Balikpapan dengan mengkaji perilaku memilih dan proses penghitungan suara. Untuk mendapatkan pemahaman yang lebih mendalam tentang masalah ini, pemilu semacam itu dibandingkan dengan pemilu non-serentak 2014. Data dikumpulkan dengan menggunakan penelitian kepustakaan dan kerja lapangan (observasi, wawancara, dokumentasi) dan dianalisis dengan menggunakan analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa pemilihan umum eksekutif dan legislatif serentak mampu mendongkrak partisipasi masyarakat karena adanya magnet pemilihan, yaitu pemilihan Presiden dan Wakil Presiden. Meskipun demikian, dapat diamati perilaku pemilih yang ceroboh disumbangkan oleh banyaknya pilihan untuk memilih calon anggota parlemen baik di tingkat nasional maupun lokal. Dalam proses penghitungannya secara manual, memakan waktu yang cukup lama sehingga menimbulkan kelelahan fisik dan psikis yang akut. Sementara di tingkat nasional menelan 894 nyawa, di daerah penelitian menelan dua nyawa. Poin penting untuk menghadapinya adalah adanya magnet pemilu (pemilihan eksekutif) yang akan mendongkrak jumlah peserta. Kedua, pemisahan pemilu serentak antara tingkat nasional dan lokal, yang akan mengurangi jumlah pilihan untuk memilih calon anggota parlemen, yang berarti mengurangi waktu penghitungan suara dan kelelahan. Terakhir, pengenalan pemilu digital, terutama saat teknologi pemungutan suara digital sangat aman dan terpercaya, serta kesiapan masyarakat.
PENGARUH PEMBAGIAN KERJA OLEH KEPALA DESA TERHADAP PRODUKTIVITAS KERJA PERANGKAT DESA DI KANTOR KEPALA DESA CITEUREUP KECAMATAN KAWALI KABUPATEN CIAMIS
Authors: Suci Indah Risyani  , Eet Saeful Hidayat
Published: June 2023

Fenomena rendahnya produktivitas kerja perangkat desa yang dipengaruhi oleh lemahnya pembagian kerja oleh Kepala Desa, indicatornya adalah capaian target Pajak Bumi Dan Bangunan, Tujuan penelitian untuk mengetahui besarnya pengaruh pembagian kerja terhadap produktivitas kerja perangkat desa. Metode penelitian yang dipergunakan adalah metode deskriptif analisis, yang memusatkan perhatian pada pemecahan masalah melalui angket selanjutnya menganalisa data hasil angket dengan cara teknik analisis data kuantitatif melalui pengelolaan data yang dideskripsikan ke tabel distribusi frekuensi, Teknik sampling adalah sampel jenuh dimana semua perangkat desa 11 orang dijadilan responden. Hasil peneltian menunjukan bahwa pembagian kerja oleh Kepala Desa diperoleh skor 31,95 atau sebesar 58,09% masuk kategori cukup baik dan Produktivitas kerja perangkat desa diperoleh skor 31,91 atau sebesar 58,01% termasuk pada kategori cukup baik. Hasil perhitungan koefisien korelasi product moment (rxy) sebesar 0,72 yang berarti variabel memiliki tingkat hubungan yang kuat, sedagkan koefisien determinasi sebesar 51,84% kategori tingkat pengaruhnya tinggi, dan 48,16% adalah epsilon. Hasil antara nilai thitung dengan ttabel , thitung sebesar 3,1141  dari ttabel sebesar 2,262, maka hipotesis Ho ditolak dan Ha diterima .
IMPLEMENTASI SISTEM AKUNTABILITAS KINERJA PADA PEMERINTAH DAERAH DI INDONESIA: SEBUAH TINJAUAN LITERATUR
Authors: Sri Lestari  , Roy Valiant Salomo
Published: June 2023

Manajemen Kinerja terdiri dari kegiatan perencanaan kierja, dilanjutkan dengan pengukuran kinerja, kemudian pengajuan laporan hasil kinerja untuk pengambilan keputusan. Manajemen Kinerja diterapkan di Indonesia melalui Sistem Akuntabilitas Kinerja Instansi Pemerintah (SAKIP) sejak tahun 1999. Dengan diterapkannya otonomi daerah pada periode yang sama, implementasi sistem akuntabilitas kinerja yang baik pada pemerintah daerah menjadi semakin penting. Penelitian ini meninjau khasanah penelitian tentang akuntabilitas kinerja pemerintah daerah yang dilakukan di Indonesia dan di dunia. Pengumpulan data dilakukan dengan mencari kata kunci yang terkait dengan pemerintah daerah dan pengelolaan kinerja di jurnal terindeks Scopus dan google scholar. Penelitian ini menemukan bahwa khasanah penelitian tentang pengelolaan kinerja pada pemerintah daerah yang dilakukan di Indonesia berkembang sangat pesat dalam 10 tahun terakhir. Secara umum, kendala yang dihadapi dalam implementasi sistem akuntabilitas kinerja terletak pada kualitas sumber daya manusia dan kapasitas organisasi. Untuk mengatasi kendala tersebut, diperlukan komitmen pimpinan dan tekanan kelembagaan eksternal baik dari legislatif maupun partisipasi publik.
IMPLEMENTASI KEBIJAKAN SMART KAMPUNG DI KABUPATEN BANYUWANGI
Authors: Gede Gusta Ardiyasa  , Ety Rahayu
Published: June 2023

Berdasarkan data dari Kemendes, saat ini dari 34 Provinsi yang ada di Indonesia, masih terdapat 11 Provinsi, 69 Kabupaten, dan 17.626 desa yang masih dalam kategori tertinggal dan 3.536 desa dalam kategori sangat tertinggal. Hal ini menandakan masih banyaknya desa tertinggal dan sangat tertinggal di Indonesia. Banyuwangi melalui implementasi kebijakan smart kampunya telah mampu membawa 189 Desanya ke dalam kategori desa Maju dan Mandiri. Tujuan penelitian ini adalah melihat bagaimana Implementasi Kebijakan Smart Kampung yang berjalan di Kabupaten Banyuwangi dan juga melihat faktor-faktor apa yang mendukung keberhasilan Kebijakan Smart Kampung. Metode penelitian yang digunakan adalah kualitatif dengan jenis penelitian deskriptif seperti yang dikemukakan Newman (2016). Hasil penelitian ini menunjukkan bahwa Implementasi Kebijakan Smart Kampung di Kabupaten Banyuwangi berjalan dengan baik. Implementasi kebijakan tidak hanya dipengaruhi oleh faktor-faktor internal tetapi juga oleh faktor-faktor eksternal. Faktor Internal yaitu empat syarat penting dalam pencapaian keberhasilan sebuah implementasi kebijakan menurut George C.E. III yaitu: Communication (komunikasi), Resources (sumber daya), Dispositions (disposisi/perilaku) dan Bureaucratic Structure (struktur birokrasi). Sedangkan faktor sksternalnya adalah partisipasi masyarakat desa, dukungan tokoh masyarakat dan dukungan stake holder.
IMPLEMENTASI KEBIJAKAN PEMERINTAH DAERAH DALAM PEMBINAAN PRESTASI OLAHRAGA OLEH KOMITE OLAHRAGA NASIONAL INDONESIA DI KABUPATEN CIAMIS
Authors: Ina Loriana Lorenza  , Aan Anwar Sihabudin
Published: June 2023

Latar belakang penelitian ini adalah pembinaan Prestasi Olahraga Oleh Komite Olahraga Nasional Indonesia di Kabupaten Ciamis mengalami pasang surut, adanya cabang olahraga yang kurang pembinaan fisik dan strategi kemenangan, sistem administrasi terbatas dan sedikit cabang olahraga yang meraih prestasi di tingkat propinsi. Hal ini disebabkan keterbatasan sumber anggaran dan minimnya tenaga terlatih yang tersertifikasi, Lemahnya pembinaan secara terstruktur (pembibitan) pada sejumlah cabang olahraga dan belum optimalnya evaluasi terhadap pembinaan yang telah dilaksanakan serta lemahnya pengawasan dalam pembinaan olahraga. Tujuan penelitian ini yaitu untuk mengetahui implementasi kebijakan Pemerintah Daerah dalam Pembinaan Prestasi Olahraga oleh Komite Olahraga Nasional Indonesia di Kabupaten Ciamis. Desain penelitian ini menggunakan metode penelitian kualitatif, teknik pengumpulan data yaitu wawancara, observasi dan dokumentasi, teknik pengolahan/analisis data penelitian ini yaitu reduksi data, penyajian data dan penarikan kesimpulan. Berdasarkan hasil penelitian bahwa implementasi kebijakan Pemerintah Daerah dalam Pembinaan Prestasi Olahraga oleh Komite Olahraga Nasional Indonesia di Kabupaten Ciamis kurang optimal. Hal ini ditunjukan dengan adanya hasil temuan penelitian, seperti kurangnya dukungan sumber daya, anggaran, pembinaan secara khusus, terstruktur seperti fisik dan strategi kemenangan, evaluasi, sistem administrasi dan data/dokumen pembinaan atlet dan lemahnya pengawasan pada pelatih setiap cabang olahraga.
PERAN BADAN PERMUSYAWARATAN DESA DALAM MENDORONG GOOD GOVERNANCE DI DESA CIBUNAR KECAMATAN RANCAKALONG KABUPATEN SUMEDANG
Authors: Garmana Deden Haria , Sozidin Zanzan Yudha
Published: June 2023

Tuijuian peineilitian ini adalah uintuik meingeitahuii peiran badan peirmuisyawaratan deisa dalam meindorong good goveirnancei di deisa cibuinar keicamatan rancakalong kabuipatein suimeidang. Meitodei peineilitian yang diguinakan dalam peineilitian ini, yaitui meitodei peineilitian kuialitatif. Teiknik peineintuian informan peineilitian, yaitui puirposei sampling. Teiknik peinguimpuilan data yang diguinakan, yaitui stuidi keipuistakaan dan stuidi lapangan yang teirdiri dari obseirvasi, wawancara, dan dokuimeintasi. Proseiduir peingolahan data meingguinakan data reiduiction, data display, data concluicion drawing veirification dan trianguilasi. Beirdasarkan hasil peineilitian dipeiroleih keisimpuilan bahwa peiran Badan Peirmuisyawaratan Deisa Cibuinar  bisa dikatakan beiluim baik, Badan Peirmuisyawaratan Deisa Cibuinar, dari seigi administrasi beiluim bisa dikatakan baik dikareinakan masih banyak hambatan yang salah satuinya dari kuialitas suimbeir daya yang kuirang optimal dan peimahaman anggota badan peirmuisyawaratan deisa teirhadap tuigas dan fuingsi masih kuirang, meindeiskripsikan Peiran Badan Peirmuisyawaratan Deisa dalam meindorong good goveirnancei di Deisa Cibuinar Keicamatan Rancakalong Kabuipatein Suimeidang. Uintuik meiwuijuidkan deimokrasi seirta tata keilola peimeirintahan yang baik di tingkat deisa seibagai mana yang teilah dicita-citakan dalam Uindang-uindang.
Digitization in industry and the transition to dynamic labor rationing are factors of effective management of business processes of an industrial enterprise and growth of labor productivity
Authors: Лютягин Д.В. , Забайкин Ю.В.
Published: June 2023

Научный доклад посвящен проблеме роста производительности труда и эффективного управления бизнес-процессами промышленных предприятий в условиях санкционного давления на российскую экономику. Данная проблематика достаточно остро встала, начиная с 3 квартала 2022 г., когда количество технологических и финансовых санкций достигло своего максимального значения и российский бизнес столкнулся как со сложностями в части сохранения рынков сбыта, а еще больше с возможностью технологического развития и обновления производственных активов. От сюда на первое место выходят организационно-технологические и цифровые методы и инструменты, позволяющие обеспечивать рост эффективности деятельности предприятий. В докладе проанализирована статистика и природа роста производительности труда. Дан анализ цифровых инструментов, позволяющих максимизировать эффективность управления предприятием. По результатам анализа сделаны научные выводы и даны рекомендации по внедрению определенного комплекса цифровых инструментов в практику промышленных предприятий.

The scientific report is devoted to the problem of increasing labor productivity and effective management of business processes of industrial enterprises in the context of sanctions pressure on the Russian economy. This issue became quite acute starting from the 3rd quarter of 2022, when the number of technological and financial sanctions reached its maximum and Russian business faced both difficulties in terms of maintaining sales markets, and even more with the possibility of technological development and renewal of production assets. From here, organizational, technological and digital methods and tools come to the fore to ensure the growth of the efficiency of enterprises. The report analyzed the statistics and nature of labor productivity growth. An analysis of digital tools that allow maximizing the efficiency of enterprise management is given. Based on the results of the analysis, scientific conclusions were made and recommendations were given on the introduction of a certain set of digital tools into the practice of industrial enterprises.
Problems of information support of students' research work
Authors: Демидова Т.Е. , Чижевская И.Н. , Чижевский А.Е.
Published: June 2023

Внимание ученых к обеспечению различных процессов жизнедеятельности человека надлежащей информацией привело к появлению многих определений понятия "информационное обеспечение" в соответствии со сферой исследования, в частности, его трактуют как создание информационных условий функционирования системы, обеспечение необходимой информацией. Исследование понятия "информационное обеспечение" позволило сделать вывод, что его многозначность зависит от сферы применения и научных подходов, которые применяют ученые до его формулировки; соответственно определяются виды информации, информационных ресурсов и процессов. Цель статьи заключается в определении и обосновании составляющих информационного обеспечения НИРС ВУЗОВ, которые удовлетворяли бы их информационные потребности на этапах учебного исследования. Информационное обеспечение НИРС понимаем как целенаправленно подобранную и систематизированную совокупность информации, которая необходима для осуществления учебного исследования, и комплекс соответствующих информационных ресурсов, источников и технологий, обеспечивающие осуществление информационных процессов на этапах исследования.

The attention of scientists to providing various processes of human life with appropriate information has led to the emergence of many definitions of the concept of "information support" in accordance with the field of research, in particular, it is interpreted as creating information conditions for the functioning of the system, providing the necessary information. The study of the concept of "information support" allowed us to conclude that its ambiguity depends on the scope and scientific approaches used by scientists before its formulation; accordingly, the types of information, information resources and processes are determined. The purpose of the article is to identify and substantiate the components of the information support of R&D universities that would satisfy their information needs at the stages of educational research. We understand the information support of R&D as a purposefully selected and systematized set of information that is necessary for the implementation of educational research, and a set of relevant information resources, sources and technologies that ensure the implementation of information processes at the stages of research.
The Effect of Carborane Substituents on the Lewis Acidity of Boranes
Authors: Dutton Jason , Akram Manjur , Martin Caleb
Published: June 2023

The Lewis acidity of primary, secondary, and tertiary boranes with phenyl, pentafluorophenyl, and all three isomers of icosahedral carboranes (ortho, meta, and para) were investigated by computing their fluoride, hydride, and ammonia affinities as well as global electrophilicity indices and LUMO energies. From these calculations, the substituent effects on the Lewis acidity follow the trend of ortho-carborane > meta-carborane > para-carborane > C6F5 > C6H5.
Structural and Electrochemical Evolution of Alloy Interfacial Layers in Anode-Free Solid-State Batteries
Authors: Sandoval Stephanie , Lewis John , Vishnugopi Bairav , Nelson Douglas , Schneider Matthew , Cortes Francisco , Matthews Christopher , Watt John , Tian Mengkun , Shevchenko Pavel , Mukherjee Partha , McDowell Matthew
Published: June 2023

“Anode-free” solid-state batteries feature high energy density since there is no anode active material upon assembly. While beneficial effects of interfacial layers at the anode-solid electrolyte interface have previously been demonstrated, the mechanisms through which they influence lithium plating/stripping are unclear. Here, we reveal the evolution of 100-nm silver and gold interfacial layers during anode-free lithium plating/stripping using electrochemical methods, electron microscopy, synchrotron micro x-ray computed tomography, and modeling. The alloy layers significantly improve Coulombic efficiency and resistance to short circuiting, even though the alloys form solute regions or particulates that detach from the current collector as lithium grows. In-situ electrochemical impedance spectroscopy shows that the alloy layers return to the interface and mitigate contact loss at the end of stripping, avoiding a critical vulnerability of anode-free cells. The enhanced contact retention is driven by uniform Li thickness that promotes spatially uniform stripping, as well as local alloy delithiation in response to current concentrations to homogenize current and diminish voiding.
Rapid Electron Transfer Self-Exchange in Conformationally Dynamic Copper Coordination Complexes
Authors: Griffin Paul J. , Olshansky Lisa
Published: June 2023

We report the electron transfer (ET) self-exchange rate constants (k11) for a pair of CuII/I complexes utilizing dpaR (dpa = dipicolylaniline, R = OMe, SMe) ligands assessed by NMR line-broadening experiments. These ligands afford copper complexes that are conformationally dynamic in one oxidation state. With R = OMe, the CuI complex is dynamic, while with R= SMe, the CuII complex is dynamic. Both complexes exhibit unexpectedly large k11 of 2.48(6) x 105 and 2.21(9) × 106 M‒1 s‒1 for [CuCl(dpaOMe)]+/0 and [CuCl(dpaSMe)]+/0, respectively. Among the fastest reported for molecular copper coordination complexes to date, that of [CuCl(dpaSMe)]+/0 exceeds all others by an order of magnitude and compares only to those observed in type 1 blue copper proteins. The dynamicity of these complexes establish pre-steady-state con-formational equilibria that minimize the inner sphere reorganization energies to 0.71 and 0.62 eV for R = OMe and SMe, respectively. In contrast to the emphasis on rigidity in the formulation of entatic states applied to blue copper proteins, the success of these two systems highlight the relevance of conformational dynamicity in mediating rapid ET.
Сhitotriosidase activity in prediction of poor prognosis in COVID-19 hospitalized patients
Authors: Schelkanovtseva Ekaterina S. , Mironova Olga Iu. , Solovev Kirill A. , Berestova Elizaveta A. , Balakhonov Alexander A. , Nagornov Ilya O. , Fomin Victor V. , Panferov Alexandr S.
Published: June 2023

Background. The identification of early predictors of poor outcomes of new coronavirus infection is necessary for optimizing patient management algorithms for hospitalized patients with COVID-19.
Aim. To study the role of chitotriosidase activity as a marker of unfavorable outcomes in COVID-19 hospitalized patients.
Materials and methods. The prospective observational single-center study included 347 patients with COVID-19 hospitalized in university clinic. In addition to the standard laboratory analysis (complete blood count, C-reactive protein, ferritin, creatinine, international normalized ratio, etc.) the blood serum chitotriosidase activity was determined at all the patients on admission. Primary endpoints were mortality from all causes and performing invasive ventilation (IV) and/or non-invasive ventilation (NIV). This study was approved by the Local Ethics Committee №12-21 (Clinical Trial Registry: NCT04752085).
Results. A total of 347 patients were enrolled in this study (average age 66 years, females 182 52.5%), 30 patients (8.6%) died during the hospitalization, 39 (11.2%) performed IV or NIV. Along with age more than 65 (odds ratio OR 10.81, 95% confidence interval CI 2.6444.22) and Neutrophil-Lymphocyte Ratio higher than 7 (OR 15.89, 95% CI 3.0981.65) chitotriosidase activity higher than 170 ng/hr/ml (OR 4.23, 95% CI 1.4512.35) were independent predictors of mortality during hospitalization. Neutrophil-Lymphocyte Ratio higher than 5.6 (OR 11.22, 95% CI 2.3753,1) and сhitotriosidase activity higher than 151 ng/hr/ml (OR 3.17, 95% CI 1.317.67) have been evaluated as predictors of performing IV/NIV.
Conclusion. Chitotriosidase level more than 151 nmol/h/mL could be considered as an early predictor of severity and poor prognosis in hospitalized patients with COVID-19.
Historical aspects of fungal sinusitis, topical issues of early diagnosis and medical care on clinical example: A review
Authors: Lengina Maria A. , Abdullin Vadim М. , Shapovalova Victoria V. , Frolova Violetta D. , Kravchenko Anna Yu. , Klepikov Semyon V.
Published: June 2023

Inflammatory diseases of the nose and paranasal sinuses provoked by fungal contamination have been on the rise over the past decades. The cause of infection, according to the literature, is more often accidental ingestion of filling material, fragments of teeth and small parts of the implant into the sinuses, followed by fungal contamination. Diagnosis of fungal sinusitis, as a rule, is not difficult, but if the use of modern technological capabilities of research and differential analysis is refused or ignored, the verification of the diagnosis may be erroneous and the routing of the patient will not be determined correctly. In the context of early diagnosis and timely treatment of inflammatory diseases of the nose and paranasal sinuses, of course, a brief historical overview reflecting the importance of the existing problem will be useful for doctors, and the given clinical example will largely help to avoid mistakes.
Algorithm for selecting patients for cochlear implantation. Lecture for physicians
Authors: Levin Sergey V. , Levina Elena A. , Kuzovkov Vladislav E. , Koroleva Inna V. , Dvorianchikov Vladimir V.
Published: June 2023

At the present stage in the world there are many methods for restoring hearing in humans, but, unfortunately, not all methods are effective for high-grade hearing loss or deafness. Carrying out timely rehabilitation of patients with a deep degree of hearing loss, especially in childhood, is extremely important for social and psychological adaptation in society. In patients with severe hearing loss, cochlear implant surgery is the most effective treatment. This operation is possible while maintaining the anatomy of the inner ear and the conduction of the auditory nerve. This lecture details the general principles of rehabilitation of patients with hearing impairments of various etiologies, the tactics of selecting patients for cochlear implantation, which is of great importance for choosing a method for treating patients with hearing loss and their psychosocial adaptation.