bluuebunny/crossref_metadata_2025 huggingface dataset:
P043 Response Loss When Transferring Patients With Inflammatory Bowel Disease From the Original Drug Infliximab to Its Biosimilar
Authors: Knyazev Oleg , Kagramanova Anna , Shkurko Tatyana , Lishchinskaya Albina , Kulakov Dmitriy , Zvyaglova Mariya , Parfenov Asfold
Published: December 2019

BACKGROUND:

Biosimilars are analogues of biopharmaceutical drugs, with a close but not identical original molecule. They are modern drugs based on proteins obtained by biological synthesis in yeast and bacteria cells. Biosimilars offer greater access to affordable treatment for inflammatory bowel diseases, and they are comparable in efficacy and safety to the original drugs.

OBJECTIVE:

To identify the frequency of response loss in patients with inflammatory bowel disease (IBD) receiving biosimilar infliximab during the year of observation.

METHODS:

In the Department of inflammatory bowel diseases of the Moscow scientific center named after A. S. Loginov of the Department of Health of Moscow, 60 patients with IBD were observed, who were transferred from the original drug infliximab (IFX) to the introduction of biosimilar infliximab, were divided into two groups. Group 1 (n = 30) patients did not receive the anti-TNF-α drug and received the original IFX drug, and were then transferred to biosimilar IFX. The 2nd group of patients (n = 30) had previous experience of receiving anti-TNF-α before the introduction of IFX and then it’s biosimilar. The loss of response in the transfer of patients with IBD from the original drug infliximab to its biosimilar was assessed according to clinical, laboratory and instrumental data. The comparative analysis was carried out by the method of four-field tables using nonparametric statistical criteria.

RESULTS:

During the year of observation among patients were did not receive the anti-TNF-α drug IBD patients receiving the original when translating IFX on the IFX biosimilar the loss of response occurred in 5 cases (16.7%) patients. In most cases, the loss of response to biosimilar (13 (43, %)) developed if IFX and its biosimilar were not the first anti-TNF-α drugs (OR - 0.385; 95% CI 0.157–0.945; x2 - 5.079; P = 0.02857).

CONCLUSION(S):

The rate of response loss when transferring patients with inflammatory bowel disease from the original drug infliximab to its biosimilar is significantly higher in patients with IBD, if IFX and its biosimilar were not the first anti-TNF-α drugs.
P054 Phenotypic and Genotypic Characterization of VEOIBD: Experience From a Single-Centre in Brazil
Authors: Santana Vianna Marina , Vieira Antunes Karina de Almeida , Barbosa dos Santos Paloma Estefanne , Seoane Marcela S , Lindoso Livia , Toma Ricardo , Deboni Mariana
Published: December 2019

BACKGROUND:

Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract, due to inadequate interaction between immune and environmental factors in a genetic susceptible host. When the age of onset is below the age of 6 years, it is called very early onset IBD (VEO-IBD). VEO-IBD is a heterogeneous disorder clinically characterized by severe and often refractory intestinal inflammation. The goal of this study was to characterize the profile of patients with very early onset inflammatory bowel disease in a single-center in Brazil.

METHODS:

We performed a retrospective study using data from an IBD outpatient clinic between January 2016 and April 2018. The patients' demographic, clinical and laboratory features were assessed by retrieval of data from medical records. The diagnosis of IBD and its phenotypes were defined according to the Paris classification.

RESULTS:

Of the 140 patients with IBD, 36 (25.7%) were diagnosed with VEO-IBD, 50% were male. Ulcerative colitis (UC) was diagnosed in 52.9%, Crohn's disease (CD) in 41.2% and indeterminate colitis in 5.9%. The mean age at onset of symptoms was 1 year and 8 months and diagnosis at 2 years and 9 months, with an average interval for diagnosis of 11 months. The average follow-up was 7.3 years (11 months to 15 years and 6 months). Family history of autoimmunity was present in 14.7%. At diagnosis, bloody diarrhea was the main symptom (67.6%), followed by abdominal pain, fever, and weight loss. Fistulizing disease was present in 8.8% of patients and anemia in 55.8%. At follow-up, sclerosing cholangitis was the main extraintestinal manifestation presented (20.6%), followed by rheumatologic manifestations (14.7%) and severe anemia requiring blood transfusion (14.7%). Immunobiological use and/or combination therapy was indicated in 41.2% of patients and 67.6% achieved mucosal healing. 27.5% patient had low weight gain despite nutritional support and 11.8% needed intestinal resection. Twelve patients had the genetic diagnosis of VEO-IBD (XIAP (2), LRBA, DGC (3), PKI3 (2), IL10R, STAT1, ATGI6L1, RIPK1) and underwent specific treatment.

CONCLUSION:

Children presenting with VEO-IBD, especially those with unusual manifestation require immune and genetic evaluation to rule syndromes that may need an alternative treatment affecting long-term prognosis. Increasing awareness of monogenic disorders affecting the intestinal immune homeostasis can help diagnose VEO-IBD, guide target therapies and prevent disease complication.
P058 Online Feedback: Perceptions About Family Planning in Men and Women With IBD in Brazil
Authors: Lima Fernanda , Machado Marta
Published: December 2019

BACKGROUND:

Inflammatory Bowel Disease (IBD) predominantly affects young and reproductive age patients. Fears that IBD itself and/or its medication may inadvertently affect stroke, pregnancy outcome and lactation safety are a significant concern for IBD patients. Myths and lack of proper education can make patients voluntarily choose not to have children, stop treatment during pregnancy and refuse lactation. The voluntary lack of children and the constitution of smaller families has been observed and reported in IBD. There is a lack of studies on the perceptions of patients in this scenario in Brazil. The objectives were to evaluate what are the perceptions about family planning in men and women with inflammatory bowel disease.

METHODS:

This prospective study was conducted by a self-completed cross-sectional online questionnaire answered by 951 female and male IBD patients over 18 years of age throughout Brazil in 2019 for 10 weeks.

RESULTS:

A total of 951 patients answered the questionnaire, 80% (761) of the questionnaires were usable. The respondent population was 76.34% female, of these 76.38% aged between 18 and 38 years, 57.29% were diagnosed with Crohn's disease, 38.54% ulcerative colitis and 4.17% colitis. undetermined. Regarding the male data, a total of 23.66% of the sample, 78.2% were between 18 and 38 years old; 69.67% were diagnosed with Crohn's disease, 27.96% ulcerative colitis and 2.37% indeterminate colitis. In both genders, female and male consecutively, 49.14/42.48% were using contraception, 41.75/50.24% had children, 50.39 / 33.02% did not plan pregnancy, 58, 10/47.57 had only one child, 30.77/28.78%, the disease disrupted family planning, 67.08/70.37% did not consider having more children, 73.22/87.56% reported that their doctors never addressed family planning during treatment and 43.73/13.81% proactively approached the issue with their doctors.

CONCLUSION(S):

It can be seen from the data presented that the theme of family planning is little explored by both doctors and patients, and that inflammatory bowel disease can influence family planning with regard to not having children or considering having more children.
P059 What Are the Biggest Concerns About Family Planning in Female and Male Perception?
Authors: Lima Fernanda , Machado Marta
Published: December 2019

BACKGROUND:

Inflammatory Bowel Disease (IBD) predominantly affects young and reproductive age patients. Fears that IBD itself and / or its medication may inadvertently affect the course and outcome of pregnancy are a significant concern for IBD patients. The objectives were to evaluate what are the major concerns about family planning in men and women with inflammatory bowel disease.

METHODS:

This prospective study was conducted by a self-completed cross-sectional online questionnaire answered by 951 female and male IBD patients over 18 years of age throughout Brazil in 2019 for 10 weeks.

RESULTS:

A total of 951 patients answered the questionnaire, 80% (761) of the questionnaires were usable. The respondent population was 76.34% female, of these 76.38% aged between 18 and 38 years, 57.29% were diagnosed with Crohn's disease, 38.54% ulcerative colitis and 4.17% colitis. undetermined. Regarding the male data, a total of 23.66% of the sample, 78.2% were between 18 and 38 years old; 69.67% were diagnosed with Crohn's disease, 27.96% ulcerative colitis and 2.37% indeterminate colitis. The biggest concerns about family planning identified among women were: Fear of having a risky/complicated pregnancy due to illness: 62.50%. Fear of medication causing harm to baby 58.27%. Fear of illness will harm the baby: 44.49%. Fear of passing the disease to the baby: 38.60%. Fear of not being able to take care of the baby because of the disease: 36.76%. Fear of failing to get pregnant due to illness: 36.76%. The biggest family planning concerns identified among men were: Fear of not being able to take care of the baby because of the disease: 39.42%. Fear of passing the disease to the baby: 28.85%. Other: 22.60%. Fear of illness will harm the baby: 19.71%. Fear of medication causing harm to baby 12.02%. Fear of not being able to get pregnant due to illness: 11.54%. Fear of partner having a risky/complicated pregnancy because of my illness: 7.69%

CONCLUSION(S):

The data show that men are less afraid than women, both care-related and drug-related, this concern is expressed even in the number of male responders, notably smaller. Among the concerns presented by both sexes, they fear that IBD could lead to a complicated pregnancy and that the disease itself could cause fetal harm or hinder the care of the baby.
P068 Assessing the Effectiveness of an Educational Series on Prior Authorization of IBD Treatments
Authors: Faler Whitney , Perez Jan , Tordoff Sharon , Gross Tara , Salinas Greg
Published: December 2019

BACKGROUND:

Prior authorization (PA) poses a burden to HCPs and their staffs when prescribing biologic therapy for patients with IBD. Our aim was to determine the effectiveness of 3 CME activities on clinician knowledge, confidence, and performance related to PA processes and success rates for biologic therapy.

METHODS:

Outcomes measurements were taken directly before (n ≥ 241) and after the activities (n ≥ 229), as well as 3-months after activity completion. This 3-month follow-up sample (n = 30) was matched at the same time to a control sample of clinicians who did not participate in the education (n = 30).

RESULTS:

4,840 learners completed the 3 modules, including 1,195 downloads of the podcast version. Key knowledge improvements were shown in helping patients with medication co-pays, use of specialty pharmacists, standardizing EHR clinical documentation of patients with IBD, requesting peer-to-peer review, and expediting submissions with the use of templates. Prior to participation, confidence in the current processes to manage prior authorizations was low. Three months following education, nearly all clinicians surveyed indicated that they were “confident” or “extremely confident” in these elements of care. Comparative analysis shows a large effect when comparing the educational learners pre- vs. post-activity (Cohen’s d = 1.37) and pre- vs. 3 –month follow-up (d = 0.55). However, comparing post-participation vs. a non-participant control is smaller (d = 0.20, 15%). This shows that our particular educational learners were coming at this program with more knowledge and practice gaps in the pre-authorization process than the general clinician population. Predictive modeling utilized a regression analysis showed increasing confidence in the use of AGA Care Pathways will significantly increase documentation of pertinent lab results and imaging related to IBD and significantly increase use of a template.

CONCLUSION(S):

This program achieved large reach with education targeted specifically to those clinicians who needed it most. The education increase clinician knowledge and confidence in the use of this knowledge to acquire prior authorization for biologics. For future PA initiatives, learners may benefit from a mock review of a PA request to best explain individual elements of the decision-making process.
P072 Takayasu's Arteritis and Inflammatory Bowel Diseases: Different Immune-Mediated Disorders or a Rare Extra-Intestinal Manifestation?: Case Series and Literature Review
Authors: Facanali Carolina , Sobrado Carlos , Queiroz Natália , Pereira Rosa Maria , Scanavini Neto Arceu , Borba Marcelo , Facanali Marcio , Nahas Sergio , Ivan Cecconello
Published: December 2019

BACKGROUND:

Takayasu's arteritis (TA) is a chronic granulomatous inflammatory vasculitis of unknown etiology that affects large arteries, especially the aortic arch and its branches, and is rarely associated with inflammatory bowel disease (IBD) (1). In most cases where this association is described in the literature, TA occurs after the diagnosis of IBD, with a time lapse of 10 to 36 months, and maintains a positive correlation with the activity of intestinal disease (2). This study aims to report a series of six cases of concomitant TA and IBD, determining its clinical features, diagnostic methods, their relationship with intestinal disease activity and responses according to therapeutic interventions. The authors also performed a review of the current literature in this field.

METHODS:

Patients were identified at our IBD unit through electronic medical record searches including the keywords “Takayasu”, “arteritis” and “vasculitis”. Data regarding patient characteristics, disease phenotype and treatment were retrospectively collected from identified patients using a standardized chart review.

RESULTS:

Six patients (50% male) with TA were identified in a total of 2,749 patients with IBD (46.8% CD, 53, 2% UC). Four patients had Crohn’s disease (CD) and 2 had ulcerative colitis (UC). The mean age of the patients at diagnosis was 33 years old (18–63). In 5 patients, TA occurred after the diagnosis of IBD, and 4 patients had another associated extra-intestinal manifestation. Vascular surgery was required in 2 patients due to extensive lesions and inflammatory activity. Most patients were clinically treated with corticosteroids, immunomodulators and anti-TNF agents. Simultaneous occurrence of both AT and CD is quite rare (1 in 10 billion) (3). However, the existence of common physiopathological pathways indicates that these conditions may be strongly associated 4. Moreover, since both diseases can be treated with the same agents, diagnostic delay may occur.

CONCLUSIONS:

The report of this case series reinforce, based on the literature reviewed, that a linkage among TA and IBD may exist. In view of the limitations of the retrospective study design further investigations are needed. Moreover, the possible role of genetic links and immune factors (T helper 1 and T helper 17 cells, cytokines, chemokines) should be explored.
P075 Inflammatory Bowel Diseases and Autoimmune Hepatitis: Is Anti-TNF Therapy an Option?
Authors: Rocha Beatriz , Queiroz Natália , Azevedo Matheus , Alexandre Carlos , Milani Luciane , Cançado Eduardo , Terrabuio Debora , Barros Luísa , Oba Jane , Leite André , Sipahi Aytan , Damião Adérson
Published: December 2019

BACKGROUND:

Comorbidities among immune mediated inflammatory disorders are frequently reported (1). Although some physicians are not aware of the potential association between autoimmune hepatitis (AIH) and inflammatory bowel diseases (IBD) it is not uncommon (2). As anti-tumor necrosis factor (anti-TNF) therapy has the potential to induce autoimmunity, including AIH (3), the safety of its utilization in this condition is unknown and often avoided by physicians.

METHODS:

Data from patients with concomitant diagnosis of IBD and AIH in the IBD unit of the Department of Gastroenterology of the Clinics Hospital of University of São Paulo was retrospectively collected based on medical records.

RESULTS:

Two female (29 and 33 years old) and one male (29 years old) patients with concomitant AIH and ulcerative colitis (pancolitis) were identified. These three patients needed to start infliximab because of persistent clinical and endoscopic activity in two of them and gangrenous pyoderma in the other case. All of them were taking azathioprine when anti-TNF was initiated. Two had type 1 AIH and one AIH with no markers. Two were cirrhotic (Child A/MELD 11 and Child B/MELD 14) with portal hypertension and one did not have signs and symptoms of cirrhosis. After a follow up of an average of 20 months under anti-TNF treatment transaminases slightly reduced (mean ALT prior treatment 50 ± 32 U/L, mean ALT during treatment 27 ± 8 U/L) and immunoglobulin G level slightly increased (pretreatment mean 2062 ± 626 mg/dL, mean during treatment 2595 ± 1158 mg/dL). Clinically, cirrhotic patients persisted with compensated liver disease (Child A / MELD 11 and Child B / MELD 15) and the one who was not cirrhotic did not have any clinical deterioration. After 19 months with anti-TNF the patient with MELD 15 (blood type B) was successfully submitted to liver transplantation and infliximab was discontinued after that. It is important to emphasize that MELD before and after anti-TNF in this case was almost the same. After 3 years, the patient with gangrenous pyoderma reactivated the skin lesions due to poor adherence to infliximab treatment, progressing to infectious complications and subsequent death.

CONCLUSION(S):

Anti-TNF do not seem to alter the course of liver disease in IBD patients with concomitant diagnosis of AIH. Due to potential side effects it needs to be applied with caution and in a multidisciplinary approach in tertiary centers with special attention to infectious complications.
P078 Obstructive Giant Inflammatory Polyposis as a Manifestation of Crohn’s Disease
Authors: Ramirez del Pilar Rodolfo , Cortes Espinosa Tomas , López Goméz Jesús , Trujillo de la Fuente Korely , Navarro Gerrard Christian , Paredes Amenabar Carlos , Aguilar Hernandez Jhonatan , Aleman Abitia Dassaev , Klimek Albarrán Gabriel
Published: December 2019

INTRODUCTION:

Giant inflammatory polyposis (GIP) is a benign condition that occurs as a rare manifestation of inflammatory bowel disease (IBD). It consists of numerous filiform polyps that give the appearance of a "worm-like mass" of >1.5 cm. It is hypothesized that they are formed during the regeneration and healing process of the colonic mucosa after an inflammatory event. They are mainly located in the transverse colon (40%), sigmoid (15%), cecum (14%), splenic flexure (7%) and hepatic flexure (7%). Its related symptoms are anemia, abdominal pain, melena, diarrhea, palpable mass, intestinal obstruction (15%) and intussusception (3%).

CLINICAL CASE:

A 44-year-old male presented with a three-month history of fever, diaphoresis, weight loss of 18 kg and difficulty in passing stools. The initial evaluation revealed cachexia, abdominal distension, tenderness, and the rectal examination was negative for bleeding. A heterogeneous lesion was noted in the sigmoid colon in the abdominal CT scan. Rectosigmoidoscopy revealed multiple polypoid lesions, the histopathology report revealed a sessile hyperplastic polyps and moderate nonspecific chronic colitis. Symptoms persisted until evolving into an acute abdomen. Dilatation of intestinal loops and hydro-aerial levels were noted in the abdominal radiography. An exploratory laparotomy was performed with findings of abdominal tumor involving the sigmoid and rectosigmoid colon. There was also a formation of a pericolonic abscess draining to the abdominal cavity, and no signs of intestinal perforation. The histopathology report was chronic transmural IBD with hyperplasia of the muscular layer and granulomatous non-casing lesions consistent with the diagnosis of Crohn's disease (CD). Treatment with Infliximab was started.

DISCUSSION:

GIP is twice as frequent in Ulcerative Colitis than in CD. It can manifest in an inactive or active stage of the disease, as presented in this case. In a similar way to a case reported by Syal et al., the first manifestation of IBD in our patient was GIP. It acted as a tumor that obstructed the intestinal lumen, and therefore the main differential diagnosis is polypoid colon adenocarcinoma. In summary, we present a case of GIP presenting with colonic obstruction as the first clinical manifestation of IBD. This is a clinical entity that must be considered by gastroenterologists, surgeons and pathologists. Surgical resection is inevitable when PIG presents obstruction and / or intussusception that cannot resolve with polypectomy, as happened with the case which we presented.
P066 A Patient Toolkit for the Transition of Care of Active Duty Patients With IBD to the Veterans Administration Healthcare System
Authors: Patel Anish , Keefer Laurie
Published: December 2019

BACKGROUND:

The shift from being an active duty military patient with inflammatory bowel disease (IBD) seen in a military treatment facility (MTF) to being a veteran receiving chronic illness care within the Veterans Administration (VA) is a time of increased vulnerability and risk for loss of continuity of care, and poor disease outcomes. A transitional care program must prioritize the psychosocial growth, self-efficacy and disease-specific knowledge of active military patients who are transitioning to VA care as well as enhance collaborative management between military and VA providers. The Department of Defense (DoD) has established the Transition Assistance Program (TAP) to assist military members to civilian life, but limit preparedness in skills to navigate/understand medical care. There is currently no available data on transition readiness from active duty military medical care to VA medical care and our objective is to determine the feasibility and acceptability of a self-management intervention.

METHODS:

We prospectively measured readiness with the use of the IBD Self-Efficacy Scale (IBD-SES) and Transition Readiness Assessment Questionnaire (TRAQ). All enrolled patients (50 active duty servicemembers) were in disease remission and underwent TAP and 50% were further randomized to undergo TRAQ-based educational and behavioral interventions via mobile applications and clinical consults.

RESULTS:

Servicemembers who underwent further TRAQ-based interventions compared to those only undergoing TAP demonstrated significant improvement in medication/appointment management, tracking/managing health issues, and talking with providers (P < 0.001). Furthermore, these servicemembers also demonstrated significant improvement in self-efficacy and self-management which was maintained up to 3 months post military discharge (P < 0.001). Servicemembers had an average VA primary care wait time of 3.5 months and for Gastroenterology specialist of 5.4 months, resulting in >60% of servicemembers having to discontinue therapy due to lapse in care (50% rate of flares) and unnecessary therapy switch.

CONCLUSION(S):

This is the first and only study to assess transitioning from active duty service to VA medical care for a chronic illness. We demonstrated improved and sustained self-efficacy outcomes with a transition program for IBD along with potential limitations in the VA transition. We have an opportunity to influence the conversation of appropriate DoD transition of medical care and to develop a model of care with wider applicability.
Knowledge analysis on some zoonosis in a private school in the municipality of Bom Jesus-PI, Brazil
Authors: De Almeida França Barbara Héllen , Sá Isael de Sousa , Alencar Naicy Maria , Barbosa Yago Gabriel da Silva , Dos Santos Jessica Sebastião , Lima Wagner Costa , Lima Dayanne Anunciação Silva Dantas
Published: December 2019

This study aimed to analyze the knowledge about some zoonosis in a private school in the city of Bom Jesus-PI, Brazil, through the application of questionnaires intended for primary school students, teachers and students´ parents. Zoonosis are transmissible illnesses in natural conditions between the animals and the human beings, and knowledge about them does not always reach the population exposed to constant risks, and it is necessary to plan health education actions in these areas. On the analysis of surveys noted significant numbers in relation to lack of knowledge on the part of interviewed in all groups. In relation to cutaneous larva migrans 37 (46,83%) of the students answered don´t know which factors were associated to the contamination, about to the prevention, 35 (44,30%) didn´t know the measures to be taken. Relating to Leishmaniasis, observed that 43 (54,43%) of the students have already heard about the disease, 37 (46,83%) answered that the dog is the responsible for transmitting and 34 (43,03%) the mosquito. In relation to the prevention, 36 (45,56%) answered combat to the mosquitoes, 35 (44,30%) using repellents, protection screens in windows and use of mosquito nets, as long as 07 (8,86%) didn´t know any prevention measure. In the amount of 79 students that answered the survey, 93,67% affirmed don´t have knowledge about giardiasis and 74,68% answered don´t know about how occurs the transmission about this zoonosis. Therefore, there is a need to carry out works that aim to provide this information to the population, especially the children because they are considered more susceptible as well as agents disseminating this information.
In situ remote sensing as a strategy to predict cotton seed yield
Authors: Baio Fabio Henrique Rojo , Da Silva Eder Eujácio , Martins Pedro Henrique Alves , Silva Junior Carlos Antônio da , Teodoro Paulo Eduardo
Published: December 2019

Crop harvest scheduling and profits and losses predications require strategies that estimate crop yield. This work aimed to investigate the contribution of phenological variables using path analysis and remote sensing techniques on cotton boll yield and to generate a model using decision trees that help predict cotton boll yield. The sampling field was installed in Chapadão do Céu, in an area of 90 ha. The following phenological variables were evaluated at 30 sample points: plant height at 26, 39, 51, 68, 82, 107, 128, and 185 days after emergence (DAE); number of floral buds at 68, 81, 107, 128, and 185 DAE; number of bolls at 185 DAE; Rededge vegetation index at 23, 35, 53, 91, and 168 DAE; and cotton boll yield. The main variables that can be used to predict cotton boll yield are the number of floral buds (at 107 days after emergence) and the Rededge vegetation index (at 53 and 91 days after emergence). To obtain higher cotton boll yields, the Rededge vegetation index must be greater than 39 at 53 days after emergence, and the plant must present at least 14 floral buds at 107 days after emergence.
Effects of short-term strength training on body composition, muscle strength and functional capacity of elderly: a systematic review and meta-analysis
Authors: Moreira Osvaldo Costa , Oliveira Claudia Eliza Patrocínio de , Maroto-Izquierdo Sergio , Cuevas María José , De Paz José Antonio
Published: December 2019

To examine the effects of short-term strength training (STST) on different manifestations of muscle strength in the lower limbs, functional capacity and body composition of people 65 years old or older. We searched the electronic databases (PubMed, Web of Science and Cochrane) to identify all publications using STST (up to 12 weeks) in people aged 65 or older, published in the last five years, prior to May 2018. Results were analyzed as continuous data using random effects to calculate the standardized mean difference (SMD) and the 95% confidence interval (95%CI). 28 studies with 921 subjects met the inclusion criteria and were analyzed. These works were grouped into three categories for analysis: Muscular Strength, Functional Capacity and Body Composition. In Muscular Strength category, the overall pooled effect estimate was 0.95 (95%CI: 0.63; 1.26), with a significant STST effect (Z= 5.93; p<0.001), over the different strength manifestations analyzed. In Functional Capacity category, the STST decreased the Time Up-and-Go test run time (SMD: -1.01; 95%CI: -1.56; -0.47) and increased the repetitions’ number performed in 30-s chair-stand test (SMD: 1.07, 95% CI: 0.79, 1.34). In Body Composition category, the overall pooled effect estimate was 0.13 (95%CI: -0.16; 0.42), without finding a significant effect of STST (Z= 0.87; p= 0.38). STST has a moderate to large effect in improving the different manifestations of muscle strength and functional capacity. However, this type of intervention has no effect on body composition.
Adjuvants plus phytosanitary products and the effects on the physical-chemical properties of the spray liquids
Authors: Assunção Heli Heros Teodoro de , Campos Saulo Felipe Brockes , Sousa Luciana Alves , Lemes Ernane Miranda , Zandonadi Cesar Henrique Souza , Cunha João Paulo Arantes Rodrigues da
Published: December 2019

The frequent tank mixing of phytosanitary products, adjuvants, and foliar fertilizers highlights the lack of information which sustains decisions about what products can be mixed for spray application. Thus, the aim of this study was to evaluate the physical and chemical characteristics of fungicides, herbicides, and insecticides in combination with some adjuvants on the Brazilian market. The experimental design was completely randomized and spray mixes of the phytosanitary products: fungicide (azoxystrobin+benzovindiflupir), herbicide (diamônio salt of N-(phosponomethyl)) or insecticide (fenpropathrin) were evaluated in combination with adjuvants (mineral oil base, foliar fertilizer or lecithin + propionic acid), and in two application rates (95 and 52 L ha-1); all with four replications. Surface tension, electrical conductivity, pH, dynamic viscosity and density of spray mixes were evaluated. The adjuvants presented characteristics capable of significantly altering the physicochemical properties of the phytosanitary spray mixes, and thus, alter the biological effectiveness and efficiency of the spray applications. However, its effects are also dependent on the phytosanitary product added to the spray mix, which makes general recommendations a difficult task. The greatest pH reduction, as well as the greatest increase in electrical conductivity, were caused by the adjuvant lecithin + propionic acid. All phytosanitary products and adjuvants studied, associated or not, resulted in a reduction in the surface tension of the spray mix in relation to water. The magnitude of change of density and dynamic viscosity promoted by adjuvants was lower than the other characteristics evaluated.
Evaluation of adipokine chemerin in hypertensive obese
Authors: Ibrahim Dalia Ramzy , Taha Mervat Elsayed , Kamal Amaal Mohamed
Published: December 2019

Chemerin is an adipokine secreted by adiopose tissue and has a role in obesity and hypertension. This study aims at assessing the level of the adipokine chemerin in obesity and/or hypertension and correlating its level with the inflammatory marker hs-CRP and predictors of atherosclerosis as lipid profile, insulin resistance, systolic (SBP) and diastolic blood pressure (DBP).Volunteers were divided into 4 equal groups according to body mass index (BMI) and blood pressure: normal weight group (BMI ≤ 24.9 kg/m2), overweight group (BMI = 25.0 – 29.9 kg/m2), normotensive obese group (BMI ≥ 30.0 kg/m2) and hypertensive obese group (BMI ≥ 30.0 kg/m2). Chemerin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, fasting blood glucose (FBG) and fasting insulin (FI) were evaluated in the mentioned groups.The results showed that there were significant increases of chemerin, hs-CRP, low density lipoprotein (LDL), SBP and DBP in hypertensive obese group compared to normotensive obese , overweight and normal weight groups. Moreover the only significant positive correlation between chemerin and hs-CRP was observed in the obese hypertensive group. The normotensive obese group showed significant increases of hs-CRP, LDL, triglyceride (TG), FBG, FI and the homeostasis model assessment-insulin resistance index (HOMA-IR) compared to the overweight and normal weight groups. Regarding the overweight group, there were significant increases in chemerin, hs-CRP, cholesterol, LDL, TG compared to the normal weight group, while the HDL levels were significantly lower compared to the two obese groups. These results revealed that the pro-inflammatory adipokine chemerin increases in obesity associated with hypertension, leading to the suggestion that there is a definite dysregulation of the pro-inflammatory and anti-inflammatory parameters towards the pro-inflammatory when hypertension and obesity are associated.
Recursos Educacionais Abertos - Padrões de Licenças para Arquivos Abertos
Authors: Vagula Edilaine , Marinheiro Edwylson de Lima , Nascimento Mari Clair Moro
Published: December 2019

O artigo tem como objetivo refl etir sobre as contribuições dos RecursosEducacionais Abertos para a construção do conhecimento escolar, analisando as licenças disponíveis no Creative Commons. Trata-se de uma pesquisa bibliográfi ca, no contexto da produção do REA, promovendo o debate sobre a questão dos direitos autorais representados por licenças. Conclui-se que a licença, quando aberta, permite que o REA seja adaptado, promovendo autonomia, por meio de uma cultura fl exível de colaboração, possibilitando inovações no campo educacional. O professor que trabalha com metodologia participativa e dialógica e faz uso do REA em sala de aula, promove situações desafi adoras que mobilizam o aluno para a construção do conhecimento, aliando ensino à pesquisa.
Representação midiática do impeachment brasileiro em 2016: o dito e o não dito
Authors: Ferreira Phillipe Farias , Silva Maiara Sobral , Guimarães Kelinne Oliveira
Published: December 2019

O estudo visa analisar o tratamento mediático no que se refere aos motivos que levaram ao impeachment da ex-presidente brasileira Dilma Rousseff. No sentido de discutir se essa representação midiática do referido impedimento foi realizada por meio de dados consolidados ou se apenas foi focada em uma abordagem mítica, baseada em mentiras, falácias, suposições e informações truncadas. Para isso, observou-se as edições do jornal Folha de São Paulo, versões impressas disponíveis na página do veículo, como recorte foi escolhido o mês de agosto de 2016, uma vez que a votação final do processo aconteceu no dia 31 deste mês.
Lola no palácio de Palas: a compossibilidade no cinema de Tom Tykwer
Authors: Cunha Bruno Bertoni , Cunha Clarice Bertoni
Published: December 2019

Propomos que o filme “Lola Rennt” pode ser utilizado como instrumento didático de apresentação da filosofia de Leibniz em “Ensaios de Teodiceia”. Para tanto, apresentamos uma análise do filme acompanhada por uma explicação dos principais conceitos do filósofo. Em seguida, criamos um cálculo para medir as ações dos personagens e através deste justificamos a tese de Leibniz, concluindo que mesmo no melhor mundo possível há a ocorrência de males.
A relação entre Mídia e o Medo do Crime: breves considerações
Authors: Souza Thaís dos Santos
Published: December 2019

O presente artigo discute a complexidade do fenômeno da relação entre a mídia e o medo do crime, tendo em vista que a mídia retrata a criminalidade, notadamente o crime violento, com pouco comprometimento com a função social. Frente a estas notícias e informações relatadas pela mídia, proporciona consequências à segurança pública, tais como o aumento do sentimento de insegurança. Diante disto, o presente estudo tem como objetivo compreender a relação entre a mídia, o medo do crime e suas consequências para a segurança pública.

Palavras-chave: Mídia. Insegurança. Consequências.
Políticas de comunicação para os conteúdos digitais como estratégia de desenvolvimento: uma observação do caso brasileiro
Authors: Carvalho Juliano Maurício de , Zambon Pedro Santoro , Arrigo Adriano Jorge Soares
Published: December 2019

No Brasil, até meados de 2011, as Políticas de Comunicação se restringiam a um processo regulatório que tangia sobretudo a questões de infraestrutura, quando o Ministério das Comunicações inicia uma Política Nacional para Conteúdos Digitais Criativos (PNCDC). Este é o tema central do artigo, que busca relatar o processo de construção dessa política e suas ações. O objetivo foi verificar de que forma a academia aborda essa temática, de modo a compreender as ações dos setores público e privado no contexto das políticas que vêm sendo desenvolvidas nos últimos anos. Para identificar, sistematizar e apresentar um esboço do cenário das abordagens acerca da temática, foi adotada uma Revisão Integrativa, que teve como objetivo identificar e resumir a construção empírica e/ou teórica.
Educomunicação: proporcionando ações formativas para educação integral
Authors: Guimarães Kelinne de Oliveira , Castilho Weimar Silva
Published: December 2019

O presente trabalho tem como objetivo apresentar reflexões sobre as contribuições da Educomunicação para formação integral, politécnica, diante da nova configuração social, a partir de discussões sobre a importância da dialogicidade no processo de ensino e da criação e desenvolvimento de ecossistema comunicativo, que é uma característica da Educomunicação, vista como uma interface entre Educação e a Comunicação. Ressaltando a importância das práticas educomunicativas na promoção da pluralidade de saberes, diversidade de experiências no contexto escolar e de alternativas para uma educação emancipatória. A metodologia utilizada consistiu em uma revisão bibliográfica. O trabalho apresenta como conclusão o papel fundamental que a Educomunicação assume na formação de sujeitos nas suas várias dimensões a partir de uma perspectiva comunicacional. A definição de Educomunicação tem como referências os autores Soares e Kaplún. Já as concepções de formação integral são apresentas a luz das ideias de Moura, Lima e Silva, Ramos, Ciavatta, Saviani e Frigotto.
Os direitos humanos à comunicação e à informação: Reflexões a partir do Cárcere Brasiliense
Authors: Marra Milena dos Santos , Paulino Fernando Oliveira
Published: December 2019

Este trabalho resulta de reflexões acerca dos direitos à comunicação e à informação como direitos humanos diante da situação de privação de liberdade. Apesar da abrangência do tema, este artigo trabalhou com as penitenciárias feminina e masculina do Distrito Federal. O objetivo foi perceber como os direitos à comunicação e à informação são percebidos pelos familiares dos presidiários(as) locais e, principalmente, se são considerados como direitos humanos. Entre outros, o embasamento teórico foi dado pela concepção de “O Direito Achado na Rua” (2017), de Souza Júnior et. al. Os resultados apontaram três entendimentos: uma invisibilidade social dos direitos humanos à comunicação e à informação; o de direitos humanos reservados aos humanos direitos; e uma visão maniqueísta do sistema carcerário e simplista acerca dos direitos à comunicação e à informação.
A revisão sistemática de literatura em psicologia: Desafios e orientações
Authors: Camilo Cláudia , Garrido Margarida Vaz
Published: December 2019

Nas últimas décadas, a comunidade científica tem assistido a um incremento exponencial na divulgação de ciência, com novas revistas lançadas anualmente e milhares de trabalhos de pesquisa publicados em vários domínios científicos entre os quais a Psicologia. No entanto, se por um lado é através da acumulação de conhecimento que a ciência avança, por outro, esse conhecimento deve ser integrado no sentido de informar a investigação, a prática e os decisores políticos.As revisões sistemáticas da literatura constituem um valioso método para dar sentido a grandes corpos de informação sobre um determinado tópico, sumariar a investigação acumulada e avaliar a robustez dos seus resultados. Assim, e atendendo à importância que as revisões sistemáticas de literatura têm na acumulação e divulgação do conhecimento, é importante que sejam conduzidas através de métodos estruturados que permitam identificar, sintetizar e avaliar todos os estudos relevantes para responder a uma pergunta específica.Neste artigo apresentam-se diferentes perspetivas e orientações sobre a condução de uma revisão sistemática da literatura no domínio da Psicologia, discutem-se os desafios associados a este método e procura-se facilitar cada etapa da condução da revisão sistemática através da apresentação de instrumentos e procedimentos recomendados na literatura.
Arte de la tierra: experiencias de creación en la tierra
Authors: Melo Sánchez Diana Paola , Gualteros Solorza Keryn
Published: December 2019

Este artículo es producto de la investigación en la línea: arte de la tierra[1], realizada por estudiantes de Licenciatura en Pedagogía Infantil (LPI) de la Universidad Distrital Francisco José de Caldas (UDFJC) con estudiantes de primera infancia en la Escuela Pedagógica Experimental (EPE). Los objetivos fueron: observar qué percepciones tienen niños y niñas acerca de su territorio, afianzar la conciencia ambiental, vivenciar y entender el proceso de siembra orgánica a partir de la creación con elementos naturales. Lo anterior, materializado en una huerta estética[2]asumida como tejido social y aula viva, donde se tratan temas como: seguridad alimentaria, tradición e importancia de plantas medicinales y ancestrales. Este proceso se asume como una alternativa de trabajo pedagógico basada en la tendencia artística de arte procesual[3], enmarcada en la investigación cualitativa, bajo el enfoque de investigación-acción educativa; esto permite la reflexión ambiental y la participación creativa de la comunidad de La Calera.[1] Arte de la tierra es, entonces, una denominación castiza de lo que en occidente se suele denominar Land Art. Como grupo de investigadoras nos interesamos por el pensamiento descolonizador que le apuesta a usar denominaciones a partir de lo que se ha construido desde América Latina.[2] Cuando nos referimos al proceso de siembra estética lo hacemos desde la noción de procesos de sensibilidad desde la noción artística y no desde los resultados de las representaciones culturales como “bello”.[3] Intentar una definición del concepto arte procesual puede resultar una tarea algo compleja. Sin embargo, desde el ámbito artístico, por ejemplo, Guash (2000) plantea que el concepto se halla vinculado íntimamente a la concreción de unas acciones expresivas en las cuales lo más importante es el desarrollo, el proceso, y no tanto la culminación de una obra, de un producto estético característico de las artes plásticas objetuales (dibujo, pintura, escultura tradicional).
Eco-alfabetización
Authors: Parra García Carolina
Published: December 2019

Comprender la importancia de utilizar adecuadamente los recursos naturales, sin afectar su disponibilidad para las generaciones futuras, es reconocer que somos parte de un todo, que nuestras acciones afectan no solo el presente y que cualquier cambio positivo o negativo que se genera de manera individual, tiene repercusiones en el Ecosistema Global. Este artículo de reflexión presenta una perspectiva crítica de la autora sobre nuestro modo de relacionarnos con el mundo y la importancia de generar una nueva educación ambiental en la escuela.
Aproximación de los jóvenes de origen cultural Muisca, asentamiento Sesquilé, a los artefactos de la biotecnología
Authors: Lozano Puentes Nelly Patricia
Published: December 2019

Esta investigación se abordada desde la perspectiva sociocultural planteada por Gurgel (2003), quien muestra la necesidad de construir currículos educativos orientados a la inclusión de aspectos propios de cada sociedad, como los sociológicos, históricos y culturales evitar la aniquilación de procesos sociales diversos de las culturas. Se busca reconocer las diferentes formas de interpretación de nuestros pueblos ancestrales, específicamente el pueblo Muisca asentado en Sesquilé, y su importancia en la enseñanza de las ciencias de la naturaleza, en este caso la biotecnología. Para ello, abordamos el problema en las maneras como se aproximan e interpretan los y las jóvenes de origen Muisca a los artefactos biotecnológicos, entendidos como artefactos culturales (Cole, 1999). Con respecto a los antecedentes y referencial teórico, se parte de varias investigaciones realizadas en el ámbito de la enseñanza de la biotecnología. Definitivamente, se trata de un concepto potente que debe ser más investigado.
Pautas de crianza y desarrollo psicomotor: una investigación en la primera infancia
Authors: Osorio Bustamante Tatiana Marcela , Cortés Quiroz Natalia , Herrera Carvajal Erika Vanesa , Orozco Restrepo Luz Angélica
Published: December 2019

La crianza se manifiesta como una forma de cuidado y orientación del desarrollo de los niños y niñas con tres componentes fundamentales: prácticas, pautas y creencias. El desarrollo psicomotor se refiere a la adquisición de destrezas corporales mediante interacciones intrínsecas y extrínsecas que se observan en el niño y niña durante toda la infancia y que lo convertirán en un sujeto con poder locomotriz-manipulativo. Lo anterior con un fin: la ganancia de autonomía y capacidad de interactuar con el mundo y poder transformarlo. El presente artículo expone los hallazgos en el marco de un proyecto de investigación con enfoque descriptivo, cuyo propósito fue describir pautas de crianza y cómo influían en el desarrollo psicomotor en los niños y niñas de 2 a 5 años, en un barrio de la región cafetera en Colombia. Los resultados muestran una relación independiente entre las variables estudiadas.
Estado de la investigación sobre jóvenes en Bogotá, Colombia y América Latina
Authors: Hernández Cano Edilberto
Published: December 2019

Este artículo presenta un análisis de algunos estudios que se han desarrollado sobre los jóvenes en los últimos años en Bogotá, ciertas regiones de Colombia y América Latina; además de pesquisas sobre representaciones sociales en el contexto escolar que toman como objeto las representaciones mutuas maestro-alumno. Se da razón del panorama en términos globales de los hallazgos, dificultades, tendencias, enfoques teóricos y perspectivas a la par que se indaga por los vacíos, contradicciones y tensiones. El artículo hace parte del proyecto de investigación doctoral “La construcción social de los jóvenes en su condición escolar: una mirada desde las representaciones sociales de los maestros de secundaria de Bogotá”, de carácter cualitativa con enfoque en el paradigma interpretativo. La pregunta que orienta el estudio es: ¿cuáles son las representaciones sociales que han construido los maestros de educación secundaria sobre los jóvenes escolarizados en las instituciones educativas de la ciudad de Bogotá?
Estudio de la cognición ambiental infantil en la ciudad de Bogotá
Authors: Benavides Delgado Jacqueline , Oviedo Palomá Gilberto Leonardo
Published: December 2019

El presente artículo aborda la representación mental infantil de un espacio urbano en Bogotá. La pregunta que orientó la investigación fue: ¿cómo se orientan espacialmente niños de diferente edad en un ambiente urbano? La hipótesis se basó en la teoría piagetana, que defiende como la orientación espacial sigue un proceso cognitivo de complejidad creciente que se inicia en la temprana infancia en estado de egocentrismo y tiende, con la maduración y el desarrollo, a la representación abstracta de la ciudad. La metodología de investigación consistió en la aplicación de mapas cognitivos a niños entre los 7 y 14 años que estudian en un espacio universitario. Los resultados demuestran la naturaleza constructivista de la cognición ambiental, pues la temprana infancia se orienta con base en elementos ambientales ligados a la interacción sensorio-motriz y tan solo en la pubertad se logran entender las relaciones entre los diferentes componentes urbanos de manera abstracta.