bluuebunny/crossref_metadata_2025 huggingface dataset:
Underappreciated Relationship: A Case of Type A Aortic Dissection Presented With Atrial Flutter
Authors: Al Rayess Nasr , Ozgur Sacide S. , Challita Ronald , Ahmad Abdullah , Ashkar Hamdallah , Elkattawy Sherif , Shamoon Yezin , Akel Tamer , Shamoon Fayez
Published: December 2024

Aortic dissection (AD) is a life-threatening emergency involving a tear in the aortic intima, leading to a false lumen. Atrial fibrillation (AF) can complicate AD, increasing management challenges and mortality risks. We report a 67-year-old male with no known past medical history who presented with a 1-day history of abdominal pain. Initial examination showed mild hypertension, elevated bilirubin level, and leukocytosis. Imaging studies indicated gallbladder distension with cholelithiasis. Discharged with outpatient follow-up for elective cholecystectomy, the patient returned 2 days later for preoperative clearance, was hypertensive and tachycardic, presented with atrial flutter, and was referred to the emergency department. A 2D echo showed left ventricular ejection fraction (LVEF) 35% to 40% and pericardial effusion. Transesophageal echocardiography (TEE) revealed LVEF 50% to 55% and no thrombus, converting to sinus rhythm postcardioversion. The TEE also suggested type A AD, confirmed by computed tomography (CT) angiography, showing dissection from the aortic valve to the left external iliac artery with pericardial effusion. Emergent surgical repair was performed, and the patient was stabilized and discharged with follow-up. This case illustrates the complexity of diagnosing and managing AD, especially with concurrent AF. Recognizing the association between AD and AF is essential as AF increases in-hospital mortality in AD patients.
Representing climate change: Dialogue about, and through, an expanded sense of scale
Authors: Castree Noel
Published: December 2024

This article explores the link between ‘scalar thinking’ and the quality of our collective dialogues about anthropogenic climate change. Climate must be thought because it can’t be experienced directly. Climate change is an idea we fill with content, both scientific and moral, cognitive and normative. The idea can catalyse profound thought, deep dialogue and well-considered collective action, but only when a broad ‘scalar sensitivity’ is operative. This article makes the case for scale as one of our most perspicuous lenses for seeing what's at stake in a climate-changed world. After commenting on the state of current dialogue about climate change, I remind readers what scale means in the English language. Thereafter, the scalar dimensions of climate change are highlighted. Scale emerges as a powerful ‘convening concept’ that can engender ‘fractal discourse’ about climate change of the sort we require. We need to think about scale beyond its obvious dimensions of space and time.
Patients with Darier disease have an increased risk of keratinocyte carcinoma: a Swedish registry-based nationwide cohort study
Authors: Inci Rahime , Gillstedt Martin , Kallionpää Roope A. , Peltonen Sirkku , Polesie Sam
Published: December 2024

Background

Darier disease is a genodermatosis which manifests as hyperkeratotic papules and superficial erosions mainly in seborrheic skin areas. This retrospective registry-based cohort study aimed to estimate the association between Darier disease and skin cancer.

Results

Patients diagnosed with Darier disease were identified from the patient registry of Sahlgrenska University Hospital (Gothenburg, Sweden) in 2016–2020. The local cohort included 13 patients. Verification of Darier disease diagnosis in the National Patient Registry showed positive predictive value of more than 90%. National Patient Registry was searched for Darier disease in 2001–2020, Swedish Cancer Registry for cancers and Prescribed Drug Register for medications. The national cohort included 770 patients and tenfold matched control cohort. Patients with Darier disease had an increased relative risk of keratinocyte carcinoma (basal cell carcinoma and cutaneous squamous cell carcinoma combined) (hazard ratio [HR], 1.6, 95% confidence interval [CI], 1.0-2.5, P = 0.036). The risk increase was significant for basal cell carcinoma (HR, 1.8, 95% CI, 1.1–2.9, P = 0.012), whereas there was a trend for cutaneous squamous cell carcinoma, (HR, 1.9, 95% CI, 0.9–4.1, P = 0.086) and cutaneous melanoma (HR, 2.4, 95% CI, 0.9–6.2, P = 0.083). Standardized incidence ratio for keratinocyte cancers was 2.9 (95% CI, 2.4–3.3. The results were consistent in two subgroup analyses adjusting for use of retinoid and/or immunosuppressive drugs.

Conclusion

Patients with Darier disease have an increased risk of skin cancer, particularly keratinocyte carcinoma. This risk was consistent even when known risk modifiers for keratinocyte carcinoma were excluded in sensitivity analyses. The results support previously proposed molecular links between Darier disease and skin cancer, but further investigations are needed. Additional studies are also required to develop clinical management recommendations for Darier disease. In the meantime, dermatologists should be aware of the cancer risk in these patients and remain vigilant, as detecting cancer can be challenging in hyperkeratotic and/or eroded skin.
The microbiome alterations of supragingival plaque among adolescents using clear aligners: a metagenomic sequencing analysis
Authors: Wang Chunlin , Zhang Chao , He Shan , Wang Qiuyu , Gao Hai
Published: December 2024

Background

White spot lesions (WSLs) may develop in adolescents undergoing clear aligner (CA) therapy with poor oral hygiene. The specific effects of CAs on the microbial composition and functional characteristics of supragingival plaques remain unclear. The present study investigated the shift in the supragingival microbial community induced by CAs in adolescents through metagenomic technology.

Methods

Fifteen adolescents (12–15 years old) with Invisalign appliances were recruited. Supragingival plaque specimens were obtained twice, before treatment (T1) and three months after treatment (T2). All the bacterial plaque specimens were analyzed for microbial communities and functions using metagenomic analyses.

Results

A total of 2,840,242,722 reads disclosed 180 phyla, 3,975 genera, and 16,497 microbiome species. During the first three months, the microbial community was relatively stable. The genus level revealed a higher relative abundance of Capnocytophaga, Neisseria, and Arachnia in the T2 period. Furthermore, the functional analysis suggested that the relative abundances of folate biosynthesis, biotin metabolism and biofilm formation-vibrio cholerae were increased in the T2 period compared to the T1 period. Finally, virulence factor analysis demonstrated that the relative abundance of genes associated with type IV pili (VF0082) and polar flagella (VF0473) was higher in the T2 period than in the T1 period.

Conclusion

In adolescents undergoing CA therapy with poor plaque control, caries progresses quickly within three months and noticeable WSLs develop on the tooth surface. Although the microbial community remained relatively steady and CA therapy did not cause significant changes in the overall functional gene composition in the first three months, virulence factors, including type IV pili and flagella, were more abundant and actively contributed to microorganism adhesion and biofilm formation.
Advancements in regulatory agility, regional collaboration, and digital transformation: insights from the Asia Partnership Conference of Pharmaceutical Associations (APAC)
Authors: Chong Sannie Siaw Foong , Ong Stephanie Hui Min , Long Siew Mei , Kanno Masaaki , Harnpramukkul Usanee , Wong Kum Cheun , Sathaye Asawari , Singh Mamta , Paliwal Manish , Do Huyen , Sou Helene , Binos Richard Simon R.
Published: December 2024

Purpose

The Asia Partnership Conference of Pharmaceutical Associations (APAC) examines recent developments in regulatory practices across Asia, focusing on regulatory agility, regional collaboration, and digital transformation. The paper identifies key improvements made by national regulatory authorities (NRAs) in adopting regulatory agilities over a two-year span. It also suggests optimizing regional reliance pathways and recommends best practices for implementing e-submission, real-world evidence (RWE), decentralized clinical trials (DCTs), and paperless e-labelling.

Methods

APAC surveyed all 14 member associations to track progress in regulatory agility implemented by our NRAs from 2022 through April 2024. Additionally, APAC assessed the uptake of regional reliance pathways and the implementation levels of e-submission, RWE, DCTs, and paperless e-labelling. Through the analysis of case studies and survey results, the paper aims to identify key trends, challenges, and opportunities in the regulatory landscape.

Results

Nine of twelve NRAs have advanced in regulatory agility, with Thai FDA leading with a 36% improvement and ranking 7th in the number of best practices implemented. e-Labeling adoption rose by 50%, and there was a 17% increase in the use of multiple sites under one license, good reliance practices, and acceptance of electronic Certificates of Pharmaceutical Product (eCPP) and Good Manufacturing Practice (eGMP). Perceived issues with the ASEAN Joint Assessment (JA) procedure include timeline constraints, limited flexibility in choosing participating NRAs, and country-specific requirements. NRAs have achieved 100% adoption of e-submissions and 50% for paperless e-labeling. Additionally, 67% accept data from DCTs and RWE using good reliance practices. However, 42% still require paper documents in e-submissions, and 50% continue to accept dossier format different from the International Council for Harmonisation Electronic Common Technical Document (ICH CTD).

Conclusions

APAC supports adopting agility best practices to reduce country-specific requirements, optimizing the ASEAN JA procedure. APAC also values strategic partnerships with NRAs, as demonstrated by the case studies of Vietnam and India. The shift towards digital transformation is evident, with 50% adoption of paperless e-labeling and 100% adoption of e-submissions, though not all processes are paperless with the use of ICH CTD dossier format. Overall, continued alignment with international standards for implementing eCTD, RWE, and DCTs is required in all 12 economies to realize the full benefits of globally harmonized digital advancement.
Quantifying fluid retention following modern pain management in TKA: an observational study
Authors: Somrak Parkpoom , Tanavalee Aree , Ngarmukos Srihatach , Tanavalee Chotetawan , Amarase Chavarin , Jaruthien Nonn , Kampitak Wirinaree
Published: December 2024

Background

Body fluid retention after major surgeries, including total knee arthroplasty (TKA), is well documented in the literature. Currently, multimodal pain control protocols consisting of several medications together with early discharge protocol may magnify this adverse event after a patient’s discharge. However, no study has focused on the quantitative and chronological changes in body fluids following modern pain management protocols for TKA. The aim of this study was to investigate the perioperative total body water (TBW) change in patient undergoing TKA.

Patients and methods

A consecutive series of 85 patients undergoing primary unilateral TKA, with uniform hospital admission, multimodal pain control, and rehabilitation protocol, had five consecutive multifrequency bioelectrical impedance analysis (BIA) scans; baseline, postoperative day 1 (POD 1), postoperative day 3 (POD 3), 2 weeks, and 6 weeks. Changes in TBW, body weight, corticosteroid-fluid retention dose–response relationship, and complications were evaluated.

Results

Seventy patients completed all five scans and follow-ups. Female patients were dominant, with a mean age of 69.5 years. There were no perioperative complications. At 24 h, the mean total fluid input and output were 3695.14 mL and 1983.43 mL, respectively, with 1711.71 mL increments and a mean accumulative dosage of dexamethasone of 15.14 mg. The mean TBW increased by 2.61 L on POD 1 and continued to peak at 3.2 L on POD 3, then gradually decreased at 2 weeks and reached the baseline level at 6 weeks postoperatively. Similarly, the mean body weight increased to 2.8 kg on POD 1, reached the maximum point at 3.42 kg on POD 3, and returned to baseline at 6 weeks.

Conclusions

Fluid retention following multimodal pain control in TKA increased from POD 1, peaked on POD 3, and gradually returned to the baseline at 6 weeks. With early discharge protocol, patient education regarding fluid retention after discharge should be considered.
Automatic construction of generic Hausa language stop words list using term frequency-inverse document frequency
Authors: Bashir Abubakar Salisu , Bichi Abdulkadir Abubakar , Adamu Alhassan
Published: December 2024

The Hausa language, spoken by a large population, is considered a low-resource language in the field of Natural Language Processing (NLP), presenting unique challenges. Despite increasing efforts to address these challenges, the quality of existing resources, particularly datasets, remains uncertain. A critical task like stop word identification is often hindered by the absence of standardized resources. This study bridges this gap by leveraging the Term Frequency-Inverse Document Frequency (TF-IDF) approach alongside manual evaluation to develop a comprehensive stop word list for Hausa. Using datasets from four reputable online Hausa news sources, comprising 4,501 articles and 1,202,822 tokens, we applied TF-IDF with a threshold of 0.001 to each dataset, identifying 91 candidate stop words by intersecting results across the datasets. After manual examination, the list was narrowed to 76 final stop words. Compared to prior study, our list increased the number of identified stop words by 6%. This standardized resource advances Hausa NLP by facilitating more effective text processing tasks, such as sentiment analysis and machine translation, and lays the groundwork for further research in low-resource languages.
Feasibility of three dimensional and strain transthoracic echocardiography in a single-centre dedicated NHS cardio-oncology clinic
Authors: O’Driscoll Patrick , Gent David , Corbett Liam , Stables Rod , Dobson Rebecca
Published: December 2024

Background

Following the publication of international cardio-oncology (CO) imaging guidelines, standard echocardiographic monitoring parameters of left ventricular systolic function have been endorsed. Recommendations highlight that either two-dimensional (2D) or three-dimensional (3D) left ventricular ejection fraction (LVEF), alongside global longitudinal strain (GLS) should be routinely performed for surveillance of patients at risk of cancer therapy-related cardiac dysfunction (CTRCD). We studied the feasibility of 3D-LVEF, 2D-GLS and 2D-LVEF in a dedicated CO service.

Methods

This was a single-centre prospective analysis of consecutive all-comer patients (n = 105) referred to an NHS CO clinic. Using a dedicated Philips EPIQ CVx v7.0, with X5-1 3D-transducer and 3DQA software, we sought to acquire and analyse 2D- and 3D-LVEF and 2D-GLS, adhering to the British Society of Echocardiography (BSE) and British Cardio-Oncology Society (BCOS) transthoracic echocardiography protocol.

Results

A total of 105 patients were enrolled in the study; 5 were excluded due to carcinoid heart disease (n = 5). Calculation of 3D-LVEF was achieved in 40% (n = 40), 2D-GLS in 73% (n = 73), and 2D-LVEF in 81% (n = 81). LV quantification was not possible in 19% (n = 19) due to poor myocardial border definition. Strong correlation existed between 2D-LVEF and 3D-LVEF (r = 0.94, p < 0.0001). Bland–Altman plot demonstrated no statistical differences in that the mean deviation between 2D-LVEF and 3D-LVEF were consistent throughout a range of LVEF values. The most persistent obstacle to 3D-LVEF acquisition was insufficient myocardial border tracking (n = 30, 50%).

Conclusion

This study demonstrates the high feasibility of 2D-GLS and 2D-LVEF, even in those with challenging echocardiographic windows. The lower feasibility of 3D-LVEF limits its real-world clinical application, even though only a small difference in agreement with 2D-LVEF calculation was found when successfully performed.
Phase II Trial of Risk-Enabled Therapy After Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer (RETAIN 1)
Authors: Geynisman Daniel M. , Abbosh Philip H. , Ross Eric , Zibelman Matthew R. , Ghatalia Pooja , Anari Fern , Mark James R. , Stamatakis Lambros , Hoffman-Censits Jean H. , Viterbo Rosalia , Greenberg Richard E. , Churilla Thomas M. , Horwitz Eric M. , Hallman Mark A. , Smaldone Marc C. , Uzzo Robert , Chen David Y.T. , Kutikov Alexander , Plimack Elizabeth R.
Published: December 2024

PURPOSE

Cisplatin-based neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care for patients with muscle-invasive bladder cancer (MIBC). Mutations in DNA damage repair genes are associated with pathologic downstaging after NAC. We hypothesized that a combination of biomarker selection and clinical staging would identify patients for cystectomy-sparing active surveillance (AS).

PATIENTS AND METHODS

We conducted a single-arm, phase II, noninferiority trial to evaluate a risk-adapted approach for MIBC. Patients with cT2-T3N0M0 MIBC underwent NAC with accelerated methotrexate, vinblastine, doxorubicin, and cisplatin (AMVAC). Pre-NAC transurethral bladder tumor specimens were sequenced for mutations in
ATM
,
ERCC2
,
FANCC
, and
RB1
. Patients with ≥1 mutation and cT0 post-NAC began AS. The primary end point was metastasis-free survival (MFS) at 2 years for the entire cohort with the null hypothesis rejected if the lower bound exact one-sided 95% CI exceeds 64%.

RESULTS

Seventy patients were enrolled, 33 (47%) had a mutation, and 25 (36%) began per-protocol AS. With a median follow-up of 40 months, the 2-year MFS for all patients was 72.9% (lower bound exact one-sided 95% CI, 62.8). The 2-year MFS was 76.0% in the AS group (95% CI, 54.2 to 88.4) and 71.1% (95% CI, 55.5 to 82.1) in the remaining patients. In the AS group, 17 patients (68%) had some recurrence and 12 (48%) were metastasis-free with an intact bladder. The 2-year overall survival (OS) was 84.3% (95% CI, 73.4 to 91.0); OS was 88.0% (95% CI, 67.3 to 96.0) and 82.2% (95% CI, 67.6 to 90.7) in the AS and not-AS groups, respectively.

CONCLUSION

Patients with MIBC treated with AMVAC followed by a risk-adapted approach to local consolidation achieved a 2-year MFS rate of 73%. The primary end point was not met, but 17% of all enrolled patients and 48% of the AS group avoided cystectomy without metastatic disease.
Transcriptional Cofactors for Thyroid Hormone Receptors
Authors: Ritter Megan J , Amano Izuki , Hollenberg Anthony N
Published: December 2024

Thyroid hormone (TH) is essential throughout life. Its actions are mediated primarily by the thyroid hormone receptor (THR), which is a nuclear receptor. Classically, the THRs act as inducible transcription factors. In the absence of TH, a corepressor complex is recruited to the THR to limit TH-related gene expression. In the presence of TH, the corepressor complex is dismissed and a coactivator complex is recruited to facilitate TH-related gene expression. These coregulators can interact with multiple nuclear receptors and are also key in maintaining normal physiologic function. The nuclear receptor corepressor 1 (NCOR1) and the nuclear receptor corepressor 2 (NCOR2) have been the most extensively studied corepressors of the THR involved in histone deacetylation. The steroid receptor coactivator/p160 (SRC) family and in particular, SRC-1, plays a key role in histone acetylation associated with the THR. The Mediator Complex is also required for pretranscription machinery assembly. This mini-review focuses on how these transcriptional cofactors influence TH-action and signaling, primarily via histone modifications.
James Monroe Whitfield, Poetry, and Martin Delany’s Revolutionary Worldmaking in Blake; or, The Huts of America
Authors: Zapędowska Magdalena
Published: December 2024

Martin Delany’s Blake, serialized in the Weekly Anglo-African in 1861–62, includes five unattributed poems from James Monroe Whitfield’s volume America and Other Poems, which appear in the novel as compositions of the Cuban revolutionary poet Placido. Largely overlooked in scholarship on Blake, Whitfield/Placido’s poems are crucial to the impending revolt of the oppressed because they foster a collective emancipatory consciousness and model, through poetic form, the meticulous organization on which the revolution relies for success. Resonating with other poems and songs quoted in the novel, they speak to broader questions of poetry’s role in building communities of resistance. In turn, Blake’s emplotment of revolutionary organizing actualizes Whitfield’s poems’ revolutionary idiom, distinguished by orientation toward a liberated future, thematic focus on imminent violence against the oppressor, the affect of outrage that sutures individuals into a volatile collective, and the rhetorical tropes of collectively voiced apostrophe, exclamation, and rhetorical question. While Blake reframes Whitfield’s poems as inspiration for the fictionalized Cuban liberation movement, the printed page of the Weekly Anglo-African with its coverage of the Civil War recasts the poems as calls to arms in the ongoing Black struggle for liberation.
Optimization of bioethanol production using stress-tolerant yeast strains isolated from household alcoholic beverages (Tella, Tej, and Areke) and molasses (as substrate)
Authors: Fentahun Mulugeta , Andualem Berhanu
Published: December 2024

Background Yeast strains that are tolerant to several environmental stresses are extensively employed to produce bioethanol from sugar-rich feedstock. Bioethanol production efficiency in Metehara and Fincha Sugar Factories (the two major sugar factories in Ethiopia) is 50% lower than that of similar factories in other parts of the world. Methods In our previous research findings, five wild indigenous strains of multi-stress tolerance yeast were isolated from traditional fermented alcoholic beverages (Tella, Tej, and Areke) in Ethiopia to the purpose of evaluate their potential use for bioethanol using sugarcane molasses as a substrate. Result The optimal parameters for maximum ethanol production were pH of 4.5, 25°Brix, 30°C, 4.0 g/l ammonium sulfate, supplement with yeast extract, and 72 h of incubation period. Under these optimum conditions, 13.13 ± 0.08% (v/v) ethanol was obtained. The yield of hydrous and anhydrous bioethanol from fermented molasses samples were produced at 94.20–95.60% (v/v) and 99.05–99.56% (v/v), respectively. Conclusion According to this finding, Saccharomyces cerevisiae isolate MUT15, Saccharomyces cerevisiae isolate MUT18F, and Saccharomyces cerevisiae isolate R9MU strains have been good candidates for production of industrial bioethanol.
A bibliometric review of functional ingredients and their efficacy in developing functional biscuits
Authors: Vishwakarma Kshama , Chandra Sekaran Varalakshmi , Patwardhan Vidya , Kamath Asha
Published: December 2024

Introduction Numerous studies have concluded that the functional ingredients benefit human health. Similarly, present times have seen exponential growth in functional food in bakery product segments like breads and biscuits. However, there is a lack of information on functional ingredients and their usefulness in developing functional bakery products. This bibliometric study addresses this gap by identifying the current research trends in functional ingredients. Objective To investigate current research trends on functional ingredients and their usefulness in developing functional biscuits. Method The study followed the “Scientific Procedures and Rationales for Systematic Literature Reviews” standards for retrieving literature. The study went through three major stages, “assembling,” “arranging,” and “assessing,” to retrieve 612 articles from the Scopus database from 2013 to 2023. Through further filtering, 395 articles were selected. Result The analysis was conducted using R Studio and VOS viewer. The performance analysis and science mapping tools were used to evaluate the articles. The results showed a 5.76% annual growth in publication trends. The most researched functional ingredients were antioxidants, bioactive compounds, and dietary fiber. The review summarized the most studied foods to develop functional biscuits and highlighted the most experimented technological advancements. Conclusion The study revealed the need for future research studies on functional ingredients with a focus on studying the technical implications of technical advancements in extracting functional ingredients from foods. The study highlights the significance of future studies based on the acceptance of functional biscuits and their sensory properties, focusing on the mass population. The study derives the possible applicability of functional ingredients in developing new formulations from publications and their usefulness in developing new formulations. This insight on the applicability of functional ingredients provides an opportunity for biscuit/cookie manufacturing to boost consumption among the population to a new ascending graph.
Expert Consensus Methods In The Humanities: An Exploration of their Potential
Authors: Rulkens Charlotte C.S. , Peels Rik , Mokkink Lidwine B. , Haven Tamarinde , Bouter Lex
Published: December 2024

Background Despite the significant role of consensus and dissensus in knowledge production, formal approaches to consensus are notably less common in the humanities compared to their frequent application in natural, social, and life sciences. This article therefore explores the potential of expert consensus methods in humanities-related research. Methods In order to do so, an interdisciplinary team of both sciences researchers experienced in consensus methods and researchers familiar with the domain of the humanities and epistemology, conducted a literary review and exchanged their expertise in multiple brainstorm sessions. Results This resulted in the identification of six key elements of expert consensus methods. It also provided for an overview of different types of expert consensus methods that regularly used in the natural, social, and life sciences: Delphi studies, nominal groups, consensus conferences, and Glaser’s state of the art method and illustrative examples from both sciences and humanities-related studies. An overview of possible purposes for applying these methods is provided to identify the research contexts in which these methods have proven their value, which can be extrapolated to humanities related issues for which these methods seem promising. Conclusions The comparisons and categorisation show that, when focusing on the purposes, there seem to be humanities-related issues that may lend themselves better to structured expert consensus methods than their subject matter and research methods might suggest. When deliberately applied in context chosen by researchers with expertise in a specific humanities domain, expert consensus methods can accelerate epistemic process, enhance transparency, increase replicability, stimulate diversity, and encourage fair processes in humanities research and the application of its findings.
Dengue infection during pregnancy and the occurrence of pathological neonatal outcome: a systematic review and meta-analysis
Authors: Goicochea-Ríos Evelyn del Socorro , OTINIANO NELIDA MILLY , Rojas-Infantas Lola del Carmen , Ocaña-Gutiérrez Víctor Raú , Gómez-Goicochea Néstor Iván
Published: December 2024

Background Dengue infection during pregnancy increases the risk of maternal and neonatal complications; therefore, the objective of this research is to determine these outcomes and describe the clinical manifestations of the infection. Methods A systematic review of studies published in PubMed, MEDLINE, LILACS, Web of Science, Scopus and thesis repositories published between 2013 and October 2023 was performed. DeCS and MeSH dengue and maternal-neonatal outcome were used. Thirteen studies were selected and the New Castle-Ottawa scale was used to assess their quality. Mantel-Haenszel hazard ratios were calculated to report the overall effect size using random-effects models. All analyses were performed in Rev Man 5.4.1 Results The 13 studies involved a population of 18,724 pregnant women, with cohorts ranging from 25 to 17,673 pregnant women. The most frequent outcomes in the pregnant women were cesarean section and postpartum hemorrhage, and in the newborns, preterm delivery and low birth weight. According to the New Castle-Ottawa scale, six studies were considered low risk and seven studies moderate risk. Dengue is a risk factor for postpartum hemorrhage (OR: 2.24), premature rupture of membranes (OR: 1.04) and cesarean section (OR: 1.13). It could not be concluded that dengue is a risk factor for the neonatal outcomes studied. The clinical picture of pregnant women with dengue was predominantly fever, abdominal pain, vomiting and nausea, anemia, dyspnea and myalgia. Conclusions Pregnancy-related changes in the immune, cardiovascular and coagulation systems, among others, increase the probability of adverse maternal and neonatal outcomes in case of DENV infection, such as postpartum hemorrhage, premature rupture of membranes, cesarean section, low birth weight and preterm delivery. Pregnant women should be considered a population at risk and should be included in dengue control, diagnosis and treatment policies.
Determining the emergency medical services innovation needs through a coordination and support action
Authors: Sofuoglu Zeynep , Jaeger Bernhard , Sofuoglu Turhan , Kamyabi Leyla , Bianchi Serena
Published: December 2024

Background The Emergency Medical Services (EMS) and emergency service sectors are constantly facing new and emerging threats. Looking back to the last couple of years, emergencies faced by Europe and third countries, such as forest fires, flooding, storms, earthquakes, and terrorist attacks, or attacks associated with chemical, biological, radiological, nuclear, and explosive materials, pose a real challenge for EMS and emergency practitioners. The aim of this study is to present the methods and steps of determining emergency medical services' gaps, challenges, and innovation needs, and to guide future projects in the idea of Pre-Commercial Procurement (PCP) as a method and practice. Methods This study was based on a mixed-method approach that combines both qualitative and quantitative research. The method mix included an in-depth literature review, detailed surveys, comprehensive workshops, and a collaborative elaboration of case studies with EMS practitioners and managers. Results The literature review undergone for Structuring the EMS Ecosystem and 11 subjects identified and “other” added for possible unclassified subjects. In total, 245 EMS practitioners completed the 57 survey questions. The survey participants were from 15 different countries. According to the findings from these surveys, EMTs across Europe do not demonstrate equal levels of disaster preparedness or access to innovative technologies, which, once implemented, would make their work more effective and save resources. The workshop and case study insights showed that sharing data between all components of the EMS ecosystem, which is essential during everyday work, especially to tackle Mass Casualty Incidents. Conclusion The iProcureSecurity CSA project laid a robust foundation for future advancements in EMS. By addressing the identified gaps and leveraging innovative solutions, the European EMS can become more resilient, efficient, and capable of meeting the challenges posed by both routine and large-scale emergency situations.
DIGITAL COMMUNICATIONS IN HR: NEW OPPORTUNITIES FOR MODERN BUSINESS
Authors: Gurova YEkatyerina , Shchegulina Oksana
Published: December 2024

Currently, communication technologies have become firmly established not only in the life of society, but have also become integral assistants in the implementation of business processes. Modern conditions for introducing new digital communication technologies into their activities pose two important tasks for organizations: providing the communication process with the necessary technical means and highly qualified specialists to ensure the effective implementation of this area of work. The introduction of digital communication technologies is of particular relevance in the work of HR services. The fairly rapid development and transformation of communicative methods of communication requires new knowledge and work skills from personnel management specialists, and from the employer to highlight a new area of activity - communications management. The purpose of the study is to, based on an analysis of modern communication technologies, determine the possibility of their use in the work of personnel services.
Code and Data Repository for Exact and Approximate Schemes for Robust Optimization Problems with Decision-Dependent Information Discovery
Authors: Paradiso Rosario , Georghiou Angelos , Dabia Said , Tönissen Denise
Published: December 2024

This software aims to solve Robust Optimization problems with Decision-Dependent Information Discovery. It implements the exact algorithms and approximate formulations described in Exact and Approximate Scheme for Robust Optimization Problems with Decision Dependent Information Discovery to solve instances of the Sensor Placement Orienteering Problem and the Robust Shortest Path Problem with and without Decision-Dependent Information Discovery. The repository contains two project: the project in "project_1" folder solves the Sensor Placement Orienteering Problem using the exact algorithm and the K-Adaptability approximation, and the Robust Shortest Path Problem using the exact algorithm, while the project in "project_2" folder solves the Robust Shortest Path Problem using the K-Adaptability approximation.
A Kounis syndrome following moxifloxacin and deflazacort administration
Authors: Morello Eugenia , Bosio Silvia , Salvadeo Sibilla Anna Teresa
Published: December 2024

Kounis syndrome (KS), characterized by the simultaneous occurrence of acute coronary syndrome (ACS) and allergic reactions, can be triggered by a range of factors and drugs. We report on the case of a patient who arrived at our emergency department (ED) with symptoms of an allergic reaction after taking moxifloxacin and deflazacort orally. In the ED, the patient experienced a 5-minute episode of oppressive chest pain. A 12-lead electrocardiogram (ECG) was registered, and elevated troponin levels were detected in the blood, suggesting myocardial damage. The patient was admitted to the internal medicine department for observation, and a second 12-lead ECG demonstrated a significant variation in the repolarization pattern. The day after, a coronary angiography revealed no significant stenosis, thus supporting, along with elevated serum tryptase levels, the diagnosis of KS. This case report highlights two potential triggers for KS and emphasizes the critical importance of early recognition and prompt treatment of KS.
Upper arm deep vein thrombosis in a patient with active lupus
Authors: Hassanein Mahmoud Farouk Kamel , Ebrahim Alaa , Joseph Stephanie Alcine , Jack Teresa , Anbazhagan Ramprasath , Olivares Miguel Fernández , Kovalska Olena
Published: December 2024

Upper extremity deep vein thrombosis (UEDVT) is relatively rare, and much less as an initial presentation of systemic lupus erythematosus (SLE). Primary UEDVT should be considered in individuals with unilateral arm swelling where the brachial, axillary, and subclavian veins are frequently involved. SLE is a chronic autoimmune disease that predominantly affects women of childbearing age and of African descent. Patients present with clinical features ranging from arthritis and arthralgias (over 90% of patients with SLE) to life-threatening hematologic, or central nervous system involvement. Individuals have an increased risk of arterial and/or venous thrombosis where the most important risk factor is the presence of antiphospholipid antibodies. Even within this condition, thrombotic events are typically seen in the legs, and UEDVT remains an unusual presentation. Here, we present a case of a 36-year-old female of African descent with a recent medical history of small joint arthralgia and vaginal bleeding due to uterine fibroids, for which she was prescribed a short course of prednisolone and norethisterone, respectively. She presented with a 2-week history of unilateral swelling in the left arm. Doppler ultrasound and later computed tomography scan with contrast indicated left UEDVT. Further investigations throughout her admission led to the diagnosis of SLE, while antiphospholipid syndrome - a common contributor to thrombosis in SLE - was notably ruled out. The patient was initiated on anticoagulants. The patient went on to later rapidly develop lupus nephritis and started on high-dose prednisolone. Given the high risk of bleeding, the decision to postpone the kidney biopsy was taken. There is limited data available about UEDVT when compared to lower extremity DVT and even fewer studies on SLE patients with thrombosis in the absence of antiphospholipid syndrome. Keeping this in mind, clinicians need to recognize idiopathic UEDVT as a potential early sign of SLE and maintain a high level of suspicion.
First record of albinism in the Quichua Porcupine, Coendou quichua in Ecuador
Authors: Brito Jorge , Lojan Pamela , Crespo Jason , Culebras Jaime
Published: December 2024

La coloración anómala es un fenómeno que se observa con regularidad en los mamíferos.  Los casos de albinismo son relativamente infrecuentes; por ejemplo, se han descrito en menos del 2 % de las especies de roedores.  Informamos por primera vez de un caso de albinismo en un puercoespín, a partir de un espécimen recogido en el noroeste de Ecuador.  Un puercoespín Quichua herido que presentaba una coloración anómala fue rescatado mientras atravesaba una carretera en las proximidades del Bosque Protector La Perla, situado en la provincia de Santo Domingo de los Tsáchilas.  Se conservó como espécimen de museo en piel, cráneo y esqueleto.  La identificación se confirmó por los caracteres externos y del cráneo, pero también secuenciamos el marcador molecular citocromo b (Cyt b) para obtener apoyo filogenético.  El espécimen es una hembra vieja.  El animal exhibe púas amarillentas en el dorso y púas blancas en el vientre.  Los ojos son rojos, mientras que el hocico, las orejas, las manos y los pies son rosados.  El análisis genético del marcador mitocondrial Cyt b confirmó la identificación del espécimen como Coendou quichua.  Este reporte presenta el primer caso documentado de albinismo en la especie de roedor Coendou quichua.  Además, este reporte incrementa a 3 el número total de especies del género Coendou con casos de albinismo, y añade a 3 especies de mamíferos registradas en Ecuador con esta condición.  También presentamos una filogenia y comentamos la posibilidad de diversidad críptica dentro del género.
The Yucatán mouse opossum (Tlacuatzin gaumeri) in Quintana Roo, México
Authors: Cervantes Fernando A. , Rivas-Villegas Ana L.
Published: December 2024

El tlacuache ratón de Yucatán (Tlacuatzin gaumeri) es una especie poco conocida hasta ahora, reportada solamente de los estados mexicanos de Campeche y Yucatán en la Península de Yucatán.  En virtud de la vecindad geográfica de estas entidades con el estado de Quintana Roo y por su similitud climática y de vegetación, se esperaría la presencia de este marsupial en territorio quintanarroense.  Se consultaron la literatura científica, los registros curatoriales de colecciones científicas en México, en el GBIF y las observaciones del portal de ciencia ciudadana iNaturalistMX.  Los registros curatoriales y una observación de campo se ordenaron en una tabla y se elaboró un mapa con QGIS 3.36.2.  Se encontraron registros curatoriales de colección científica de T. gaumeri para el estado mexicano de Quintana Roo.  Similarmente, se encontró una observación (grado investigación) de ciencia ciudadana para Quintana Roo, cerca de la porción occidental de la Reserva de la Biosfera de Sian Ka’an.  Los registros amplían la distribución geográfica conocida de T. gaumeri 139 km (en promedio) hacia el este de la Península Yucateca.  Los datos registran por primera vez a T. gaumeri en Quintana Roo y confirman su endemicidad en ese estado; asimismo amplían la distribución geográfica conocida de este marsupial.  Aunque su presencia coincide solo con un área natural protegida, puede contribuir a su conservación.  Se requiere todavía determinar si aplica para alguna categoría de riesgo, pero los resultados contribuyen al inventario faunístico de la Península Yucateca.
Anti-Neural Autoantibodies Associated with Major Depressive and Bipolar Disorders: Characterization of Psychopathology and Literature Review
Authors: Hansen Niels , Teegen Bianca , Fitzner Dirk , Wiltfang Jens
Published: December 2024

Background; Neural autoantibodies in depression are rarely reported, and their prevalence in depression is unknown. Our study was therefore dedicated to analyzing the frequency of neural autoantibodies in a cohort of patients presenting mood disorders. In addition, the study served to describe the clinical psychopathology of the patients with depressive disorders and neural autoantibodies.
Methods; We retrospectively examined a cohort of 41 patients with major depressive disorder and bipolar affective disorder. Patient files were evaluated for clinical data, psychopathological assessment, as well as magnetic resonance imaging (MRI), electroencephalography (EEG), cerebrospinal fluid analysis findings and serum and/or cerebrospinal fluid (CSF) neural autoantibodies.
Results; Our study revealed neural autoantibodies in of 6 of 41 (14%) of patients with mood disorders suspicious for an underlying organic cause. CSF autoantibodies were verified in 3 of 41 (7%) patients with mood disorders. No differences between antibody-positive and -negative mood disorder patients were identified regarding psychiatric syndromes or CSF, EEG, MRI and psychopathological parameters. However, mood-disorder patients with autoantibodies revealed less loss of drive than those mood disorder patients without autoantibodies.
Conclusions; Our findings indicate that a minority of mood disorders might be associated with neural autoantibodies. The proof of CSF autoantibodies in three of six autoantibody-positive patients suggests highly likely paraneoplastic or autoantibody-mediated autoimmunity. Our study’s novelty is the in-depth phenotyping of autoantibody-positive depressed patients via two different psychometric scoring systems. More research is required to confirm these preliminary results in larger cohorts with more homogeneous patient groups.
Redescription of Carinetini Distant, 1905 (Hemiptera: Cicadidae: Cicadettinae) including a key to the genera, three new species, two new combinations, a new record and comments on the taxonomic position of the genus Paranistria Metcalf, 1952
Authors: SANBORN ALLEN F.
Published: December 2024

The description of Carinetini Distant, 1905 is expanded and updated to provide a more detailed set of characteristics in order to differentiate the taxon using a modern set of morphological features. The African genus Paranistria Metcalf, 1952 is reassigned to the Parnisini Distant, 1905 with related African taxa leaving Carinetini including only the Neotropical genera Ahomana Distant, 1905, Carineta Amyot & Audinet-Serville, 1843, Guaranisaria Distant, 1905, Dorachosa Distant, 1892 (=Herrera Distant, 1905), Novemcella Goding, 1925, and Toulgoetalna Boulard, 1982. A generic key to the Carinetini is provided. The cicada species Carineta cretatabasilaris sp. nov., Dorachosa bilabeculafissura sp. nov. and Dorachosa guimararesensis sp. nov. are described as new. A first record of Carineta cingenda Distant, 1883 from French Guiana is provided expanding the known range of the species. Carineta picadae Jacobi, 1907 and Herrera castaneanigricula Sanborn, 2024b are reassigned to Dorachosa to become Dorachosa picadae (Jacobi, 1907) comb. nov. and Dorachosa castaneanigricula (Sanborn, 2024b) comb. nov., respectively.
Parameter Optimization of Electromagnetic Sensing and Driving Scheme of a Compact Falling-body Viscometer
Authors: Zhang Kun , Zhang Hongbin , Xue Yuan , Ma Jinyu , Han Jiqing , Huang Xinjing
Published: December 2024

In order to achieve automatic fast reset of the falling-body (FB) viscometer, and reduce the volume of the device and the amount of sample used, this paper proposes to use a single coil to reset the FB and use another single coil to measure the FB position. In this paper, the characterization ability of the sensing coil impedance to the FB position and its influencing factors, and the reset ability of the driving coil to the FB and its enhancement factors, are studied via electromagnetic finite element simulations and experiments. There is a linear zone between the FB position and the sensing coil impedance, with the slope being largest. The lower limit of the FB motion should be designed in this linear zone to accurately determine the moment when the FB reaches the lower limit point. Increase in the FB height, and in the number of turns of the sensing coil, and decrease in the wire diameter are beneficial to the FB positioning. There is a maximum force point when the FB approaches the driving coil, and the FB’s motion range needs to cover this point for reliable reset. Using iron plugs allows the FB to obtain greater electromagnetic attraction and ensure its successful reset. Experimental results show that the device requires only 1 mL of sample to measure liquid viscosity. For 9.5-1265 mPa⋅s dimethyl silicone oil, the average absolute value of the relative measurement error is 0.22% and the maximum value is 4.3%.
Correlations of Salivary and Blood Glucose Level Detection using Flexible Sensor Technique
Authors: Rahayu Yusnita , Arifa Fildza , Alaydrus Mudrik , Anhar  , Praludi Teguh , Masdar Huriatul , Alam Syah
Published: December 2024

Indonesia had a total of 19.47 million individuals diagnosed with diabetes in 2021, the fifth position globally, as reported by the International Diabetes Federation (IDF). Diabetes requires periodic medical examinations, yet many individuals are hesitant to utilize invasive medical devices. The ring slot circular resonator (RSCR) inspired this sensor’s design. Non-invasive glucose measurement was done with flexible 2.45 GHz sensors. The reflection coefficient (S11) simulation result is -20.76 dB at 2.458 GHz and 894.8 MHz bandwidth. Saliva samples obtained from 20 individuals were subjected to 20 separate tests. Before collecting saliva samples, the volunteers’ blood sugar levels were assessed. Research indicates that the appropriate frequency range for average blood sugar levels (less than 125 mg/dl) is 1.55 GHz to 2.16 GHz, while diabetes patients with blood glucose levels (BGL) above 125 mg/dl had frequencies above 2.3 GHz. Test results show a positive correlation between glucose level and testing frequency. In addition to blood samples, saliva samples can serve as alternate specimens for assessing an individual’s BGL.
Tunable Broadband Absorber Based on Active Frequency Selective Surface
Authors: Zhang Bingmei , Kong Xianglin , Xu Ruofeng , Zhao Lei , Song Hang , Zhang Shengjun , Liu Jiaqi
Published: December 2024

In this paper, a tunable metamaterial absorber (MMA) based on active frequency selective surface (FSS) is proposed, which can dynamically tune three absorption bands. The equivalent circuit model (ECM) was used to design the MMA and elucidate its mechanism of switchable absorption. By changing the state of the PIN diode in the lossy layer and FSS layer, the absorption frequency can be tuned continuously. The tuning of the three absorption bands from S- to C-band is achieved. The numerical simulation results show that the described MMA can achieve a bandwidth of 6.2 GHz and can dynamically tune between 1.86-2.70 GHz, 2.42-5.29 GHz, and 4.16-8.10 GHz. The reflectivity is lower than -10 dB, and the fractional bandwidth reaches 125.3%. In addition, the MMA’s prototype was produced and measured. The measurement results are generally consistent with the simulation results.