bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypotension as a first presentation of myasthenia gravis in an elderly patient scheduled for cervical disc surgery: a case report
Authors: Seyam Sameh Hamdy , Ali Mohamed Abdelhamid , Razein Hassan , Elkousy Islam , Schandran Shyam Babu
Published: February 2024

Myasthenia gravis presents with progressive skeletal muscle weakness. The disease can affect any group of muscles, along with the proximal limb and neck musculature. Elderly patients, especially those over 60 y of age, frequently face extensive delays in diagnosis, or are misdiagnosed, as the symptoms may be erroneously attributed to different other causes frequently seen in this age group, such as degenerative joint disease, disk herniation, osteoporotic vertebral fractures, or metastases. We present a case of a 61-year-old male patient with significant medical records of hypertension, who presented with neck pain for a few months, posted for cervical disc surgery at C6-7  with cage fixation. Two attempts for general anesthesia induction were complicated by severe hypotension. He was evaluated with low-frequency repetitive stimulation, Acetyl-choline receptor antibody, and P/Q calcium channel antibodies. The low-frequency Repetitive Nerve Stimulation (RNS) showed a severe reduced response that was corrected after rest, which was consistent with the diagnosis of myasthenia gravis.
Key words: Myasthenia; Pain, Neck; Hypotension; Weakness
Citation: Seyam SH, Ali MA, Razein H, Elkousy I, Schandran SB. Hypotension as a first presentation of myasthenia gravis in an elderly patient scheduled for cervical disc surgery: a case report. Anaesth. pain intensive care 2023;27(6):763−767; DOI: 10.35975/apic.v27i6.2351
Received: July 08, 2023; Revised: September 16, 2023; Accepted: October 09, 2023
The role of prothrombin complex concentrate to control critical bleeding after splenectomy for blunt abdominal trauma; A case report
Authors: Laksana Aditia Pria , Manggala Sidharta Kusuma , Irawany Vera
Published: February 2024

Blunt abdominal trauma is an event that can cause massive internal bleeding and can be life-threatening. Splenectomy is often performed to treat organ injuries in patients with blunt abdominal trauma. However, splenectomy can cause hemostasis problems, which can cause more bleeding and risk complications such as Acute Kidney Injury (AKI).
This case report aims to discuss the role of prothrombin complex concentrate (PCC) in treating bleeding and preventing AKI in blunt abdominal trauma patients after splenectomy at Fatmawati Hospital, Jakarta, Indonesia.
A 15-year-old woman experienced blunt abdominal trauma due to a sports accident and sustained internal bleeding. After a thorough evaluation, she underwent an emergency splenectomy to stop the bleeding. However, patients developed hemostasis problem which made the control of postoperative bleeding difficult. To overcome this problem, patient was administered PCC intravenously, which resulted in significant improvement in controlling postoperative bleeding. The hematocrit level and red blood cell count steadily increased, indicating the effectiveness of PCC in improving the patient's hemostasis.
PCC can play an important role in treating post-splenectomy bleeding in patients with blunt abdominal trauma. Apart from that, the use of PCC can also help prevent AKI, which is a serious and life-threatening complication. Further research and clinical trials are needed to confirm the benefits of using PCC in a broader patient population with similar conditions.
Abbreviations: AKI- Acute Kidney Injury; PCC- Prothrombin Complex Concentrate
Keywords: Acute Kidney Injury; Bleeding; Blunt Abdominal Trauma; Prothrombin Complex Concentrate; Splenectomy
Citation: Laksana AP, Manggala SK, Irawany V. The role of prothrombin complex concentrate to control critical bleeding after splenectomy for blunt abdominal trauma; A case report. Anaesth. pain intensive care 2024;28(1):177−181; DOI: 10.35975/apic.v28i1.2289
Received: September 13, 2023; Reviewed: October 29, 2023; Accepted: December 19, 2023
The effect of different doses of neostigmine plus metoclopramide on the gastric residual volume in patients under enteral nutrition in intensive care unit
Authors: Moshari Mohammadrea , Tahmasebi Zahra , Dahi Mastaneh , Vosoughian Maryam , Dabir Shideh , Madadi Firoozeh , Tabashi Soudeh , Ariannik Mohsen , Khatiri Mohammad Ali Khabiri
Published: February 2024

Background & Objective: Gastric motility disorder is common in patients admitted to an intensive care unit (ICU), leading to increased morbidity and mortality. We investigated the effects of different doses of neostigmine in combination with metoclopramide on gastric residual volume (GRV) in ICU patients on enteral feeding.
Methods: In this double-blind clinical trial, 144 patients hospitalized in the ICU who were under enteral nutrition through nasogastric (NGT) or orogastric (OG) tube were randomly allocated to four groups. In all four groups, 20 mg of metoclopramide was prescribed IV slowly within one minute. In groups A, B, and C, 1, 1.5, and 2 mg of neostigmine were injected IV, respectively. Group D received only 20 mg of metoclopramide. All patients were gavaged every 4 h with 300 ml. The patient's head was kept at a 45° angle. To determine GRV, aspiration was done through NG tube or OG tube before the start of infusion and then at 3, 6, 9, and 12 h after the end of infusion.
Results: There was no significant difference between the studied groups in terms of demographic variables such as age, blood pressure, heart rate and BMI (P > 0.05). The average difference of SOFA and APACHE and laboratory factors between the groups was not significant. The results of the comparison of the marginal averages of the residual volume of the stomach at different hours of the day showed that the amount of the residual volume at all hours had a significant average difference with each other. The addition of different doses of neostigmine had a significant effect on the residual volume of the stomach after 3 and 6 h (P < 0.05). Meanwhile, a dose of 2.0 mg of neostigmine had the most of the change 3 h after administration.
Conclusion: Administration of neostigmine in combination with metoclopramide in ICU patients on enteral feeding significantly reduces the residual volume of the stomach within 12 hours after the treatment.
Abbreviations: APACHE- Acute Physiology And Chronic Health Evaluation; GRV - Gastric Residual Volume; NG – Nasogastric; OG - Orogastric; SOFA- Sequential Organ Failure Assessment; VAP - ventilator-associated pneumonia
Key words: APACHE; Enteral Nutrition; ICU; Metoclopramide; Neostigmine; SOFA
Citation: Moshari M, Tahmasebi Z, Dahi M, Vosoughian M, Dabir S, Madadi F, Tabashi S, Ariannik M, Khatiri MAK. The effect of different doses of neostigmine plus metoclopramide on the gastric residual volume in patients under enteral nutrition in intensive care unit. Anaesth. pain intensive care 2024;28(1):33-38.
DOI: 10.35975/apic.v28i1.2378
Received: August 06, 2023; Reviewed: September 11, 2023; Accepted: September 21, 2023
Brain Death: The Dilemma Continues
Authors: Hussain Abid
Published: February 2024

Despite being introduced over half a century ago and having undergone multiple refinements, the debate surrounding brain death persists within the medical community. Acknowledging the premise that brain death is not synonymous with actual death[i] but rather a novel construct introduced to meet societal demands gives rise to a series of quandaries for Muslim physicians. If brain death is not acknowledged as death under Islamic law, the harvesting of organs from individuals declared brain dead would be construed as an act of homicide. Additionally, granting consent for "deceased" organ donation might be perceived as granting authorization for the cessation of one's own life in the operating theatre.
Keywords: Brain Death; Islamic Death; Islamic Bioethics; Deceased Organ Donation
Citation: Hussain A. Brain Death: The Dilemma Continues (Editorial). Anaesth. pain intensive care 2024;28(1):01−04; DOI: 10.35975/apic.v28i1.2386
Received: January 01, 2024; Accepted: January 10, 2024
AI (Artificial Intelligence) in Daily Life
Authors: Talati Dhruvitkumar
Published: February 2024

Natural language-based interfaces are frequently used in user contact
with virtual assistants to overcome accessibility issues that some user
groups may encounter. Although there are worries about how AI may affect
jobs and possible biases in the use of virtual assistants, the
technology has promise in a number of areas, such as everyday work
support and mental health therapy. This paper evaluates the uses of AI
in daily life in a comprehensive and informative manner.
Pengembangan Buku Petunjuk Praktikum pada Matakuliah Fisiologi Tumbuhan I
Authors: Hakim Arief Rahman
Published: February 2024

The aim of this research is to develop a practical manual for the Plant Physiology I course. This research is included in development research. The design used in this research uses a 4D model which was adapted into a 3P model (Definition, Design and Development). The research instruments used were validation sheets and readability test sheets. This development research uses two expert validators, namely content/material experts and teaching materials experts as well as readability tests by students. Data collection techniques use validation techniques and readability tests. The data analysis technique used is the percentage technique. The research results showed that the value of the content/material expert validator was an average of 3.15, the teaching material expert validator was an average of 3.11, and the readability test by 20 students was an average of 3.08. Thus, teaching materials in the form of a Plant Physiology I practical manual are suitable for use without revision.
Identifikasi Tumbuhan sebagai Repellent terhadap Nyamuk : Review
Authors: Lestari Sri Wahyuni Budi
Published: February 2024

Indonesia as one of the tropical countries in the world with high air humidity triggers the breeding of mosquitoes such as Aedes aegypti which is one of the vectors of Dengue Hemorrhagic Fever (DHF). This type of research is a literature study using the literature review method. This method is carried out by evaluating, interpreting and explaining the ideas discussed in several studies by searching for sources from the Google Scholar database. The selection of the type of article is based on the year of publication, the article can be accessed in its entirety, and discusses plants as repellents against mosquitoes. Based on research results from several sources, there is a biological prospect as an anti-mosquito agent for anti-mosquito and repellent/repelling power because it contains bioactive compounds, such as alkaloids, saponins, flavonoids, phenols, tannins, steroids and terpenoids. These compounds enter through respiratory contact and digestive/gastric toxins so that mosquitoes experience mortality/death. This compound also blocks chemical receptors (chemoreceptors) found on the palpus and antennae of mosquitoes, so that mosquitoes escape without sucking blood again. It is hoped that this review article can provide information regarding repellent plants as anti-mosquitoes. It can be concluded from the results of the review that there are plants that have repellent power against Aedes aegypti with increased protective power according to the increase in concentration of the plant used, as well as the length of exposure of the extract from each plant to the skin.
Fatores do desempenho de professores na utilização de estratégias de Aprendizagem Baseada em Problemas
Authors: Bezerra Ângela , Sá Patrícia Alexandra Pacheco de , Araújo Ana Cláudia Uchôa
Published: February 2024

Os direcionamentos da educação apontam para inserção dos alunos como participantes ativos na construção do conhecimento. Várias são as estratégias didáticas que podem ser implementadas contemplando essa característica, dentre elas, a Aprendizagem Baseada em Problemas (ABP). Assim, este artigo tem como finalidade identificar fatores favoráveis e limitantes de desempenho de professores nas estratégias de ABP, recorrendo-se às tecnologias digitais, em um curso de formação a distância. Desse modo, realizou-se um estudo de caso, e, por meio da análise qualitativa das notas da pesquisadora e da autoavaliação dos professores/participantes, coletadas durante o curso de formação, foram evidenciados mais fatores favoráveis do que limitantes. Pode-se destacar: motivação, autonomia, protagonismo, superação de atividades desafiadoras, assim como limitação de tempo e cansaço mental.
Abstract
The education guidelines point to the students as active participants in the knowledge construction. There are several teaching strategies that can be implemented considering this characteristic, among them, Problem-Based Learning (PBL). Thus, this article aims to identify favorable and limiting factors for teachers' performance in PBL strategies, using digital technologies, in a distance learning course. A case study was carried out through qualitative analysis of the researcher's notes and teachers/participants’ self-assessment, collected during the training course. It highlights more favorable factors than limiting factors. We can highlight: motivation, autonomy, protagonism, overcoming challenging activities, as well as time limitations and mental fatigue.
ATTRIBUTIVE PHRASES WITH INNER PREDICATION IN ENGLISH-LANGUAGE FICTION: FEATURES AND TRANSLATION INTO RUSSIAN
Authors: Трегубова Ю.А.
Published: February 2024

В статье рассматриваются особенности функционирования атрибутивные словосочетаний с внутренней предикацией в англоязычном художественном тексте и переводческие стратегии при их передаче на русский язык. Актуальность данного исследования обусловливается постоянным развитием и изменением синтаксиса английского языка, что проявляется в появлении новых синтаксических конструкций – многокомпонентных атрибутивных словосочетаний, перевод которых на русский язык может сопровождаться некоторыми сложностями. В статье представлен анализ особенностей и типов атрибутивных групп с внутренней предикацией в англоязычной художественной литературе. В результате исследования контекстов употребления изучаемых словосочетаний была выявлена их основная функция в художественном тексте – воздействие на читателя через создание образов героев художественного произведения при помощи языковых средств. Эмпирический материал исследования позволил изучить структурные особенности и семантику многокомпонентных адъюнктов-композитов. В результате анализа материала корпусных данных, полученных из современной англоязычной художественной литературы, определены наиболее распространенные типы адъюнктов с внутренней предикацией, среди которых называются двух- и многокомпонентные композиты-словосочетания. В результате сравнительно-сопоставительного анализа оригиналов атрибутивных словосочетаний с внутренней предикацией и вариантов их перевода были определены основные приемы и переводческие трансформации, использующиеся при передаче изучаемых типов словосочетаний на русский язык, а именно: лексические, грамматические и комплексные. Отмечено, что невозможно использовать одну конкретную трансформацию или способ перевода, поскольку именно полный комплекс переводческих инструментов позволит осуществить адекватную и эквивалентную передачу англоязычных атрибутивных словосочетаний с внутренней предикацией на русский язык.
VARIATIVITY OF THE «HORROR OF DEATH» IN RUSSIAN LITERATURE
Authors: Сулемина О.В. , Попова Ю.С.
Published: February 2024

Следуя работам А.А. Фаустова, С.В. Савинкова и А.А. Кретова, мы основываемся на понимании универсальности отдельных культурных, философских и литературных категорий для русской и мировой культуры и литературы. Мы также придерживаемся деления русской литературы на культурно-временные «срезы» и выделяем универсалии, характерные для каждого среза. В данной работе мы говорим об универсалии «ужас/ ужасное» и такой ее реализации, как «ужас смерти». Дается определение «ужасного», анализируется его репрезентация в творчестве русских писателей XVIII-XIX веков. Приводятся иллюстрации из зарубежных работ по философии и культурологи, которые подтверждают универсальность данной категории. При этом стоит отметить, что категория «ужасного» не является наиболее частотной, однако мы относим ее к значимым в связи с другими категориями и ее смысловой нагруженностью. Действительно, многие ученые сходятся во мнении, что человек проживает свою жизнь под действием осознаваемого или бессознательного страха/ ужаса смерти, который обусловливает его поступки и оказывает значительное влияние на формирование личности. В литературных произведениях смерть и отношение к ней героев также играют значительную роль. Мы в своей работе контурно обозначаем типичное для различных «срезов» русской литературы понимание «ужаса смерти» и попытки его преодоления. Особенное внимание уделяется «артистическому» преодолению «ужаса смерти» в творчестве А.С. Пушкина. Показано, как творчество позволяет лирическому субъекту создать собственный художественный мир, в котором он является демиургом и сам влияет на такие категории, как «жизнь» и «смерть». Это позволяет трансформировать ужас смерти в творческую деятельность и таким образом преодолеть его. Можно сделать выводы о том, что «ужас смерти» воспринимается по-разному в разные эпохи, но во всех случаях является одной из основополагающих категорий в литературе и культуре. Многие авторы в своих произведениях показывают его преодоление с помощью веры, разума, смирения, творчества.
А.Т. ТВАРДОВСКИЙ В ВОСПОМИНАНИЯХ СОВРЕМЕННИКОВ (ЗАГОРЬЕ М. ТОМПСОН И ЭПИСТОЛЯРНЫЙ ДИСКУРС А.В. МАКЕДОНОВА)
Authors: Королева И.А.
Published: February 2024

В статье рассматривается личность великого российского писателя Александра Трифоновича Твардовского через восприятие ее двумя известными людьми 90-х гг. ХХ века: советского критика и литературоведа, земляка и друга Твардовского – Адриана Владимировича Македонова и американской исследовательницы творчества поэта профессора Маргареты Томпсон. Представляется отношение Маргареты Томпсон к малой родине поэта и его семье. Анализируется эпистолярный дискурс Македонова и Томпсон на примере первого письма критика, стиль которого отражает особенности языковой личности самого пишущего, его отношение к Твардовскому и – шире – к российской действительности описываемого времени. Доказывается, что имя великого мастера слова связывает людей двух полярных миров – русского и американского. Затрагиваются вопросы оценки думающими и высоко интеллектуальными людьми личностных характеристик Твардовского и его соратников и близких.
Respect Value Found in Turning Red Movie
Authors: Aditya Kadek Kenaka , Ni Made Verayanti Utami
Published: February 2024

This research focuses on Meilin 's feelings for self - expression and how Meilin respects her ancestors and parents. Meilin is the main character of the novel. It doesn't stop there; Mei is also an active child and excels in school. Mei is always obsessed with making her parents happy until she forgets her own happiness. She couldn't express herself the way she wanted to. However, after going through many events, Mei decided not to hold back anymore. Mei then tried to be more honest with herself, unfortunately it had some effect on her. This is the background of this research by describing the respect that is shown by Meilin towards parents and ancestors qualitatively. The method used in to conduct this study is by observing combined with note-taking techniques. The first step of this research is to watch this film and read the script, after that record every sentence that contains moral values and record how the main character describes these moral values. Moral value of respect was examined using the theory proposed by Linda and Eyre (1993) in their book Teaching Your Children Values. Based on the classification results, the study analyses conversations that contain moral values of respect. shown by the antagonist and protagonist characters in a dialogue
The Rehabilitation of Post-Traumatic Stress Disorder of Servicemen: Certain Aspects
Authors: Pashkov Vitalii M. , Sydorenko Anna S. , Gnedik Yevgen S.
Published: February 2024

Aim: This article reviews and assesses the problematic and topical issues of rehabilitation of servicemen who have post-traumatic stress disorder (PTSD) caused by trauma and stress during and after the completion of combat operations, and special tasks. Analysis and generalization of types of rehabilitation are based on international experience and identification of measures to overcome PTSD. Materials and Methods: The research is based on the analysis of international documents, empirical and analytical data of the World Health Organization, international and public organizations dealing with the treatment and rehabilitation of military personnel and war veterans, scientific and analytical studies related to the types of rehabilitation used to overcome the negative consequences of PTSD. Both general and specific scientific methods are applied as the foundation of the methodology: dialectical; systemic and structural; conceptual and comparative; methods of analysis, synthesis, and observation. Conclusions: The duration of stay in the combat zone, the deaths of comrades and civilians, violent acts, and the use of weapons against the enemy undoubtedly affect the psychological state of servicemen and can lead to the development of post-traumatic stress disorder. Psychological support and rehabilitation of servicemen are necessary to restore psychological health and reduce the severity of the consequences of psychological injuries, stressful conditions, and aberrant behavior outside the combat zone. Introducing new methods, technologies, tools, development of programs, and guidelines for rehabilitating military personel suffering from post-traumatic mental disorders should be universally accepted. International experience is especially important for developing and improving the rehabilitation system. International organizations should develop a single, generally accepted mechanism for overcoming the consequences of PTSD, taking into account the practice of countries that are actively working in this direction.
The European Political Community: A Polish perspective
Authors: Cianciara Agnieszka K.
Published: February 2024

This article seeks to investigate the birth and evolution of the European Political Community – a pan-European multilateral coordination format that has emerged at the initiative of France and in reaction to the Russian full-scale military aggression in Ukraine. The analysis draws on official speeches, think-tank briefs, and the Author’s participatory observation conducted during international expert meetings held in early 2023. It is argued that the EPC is still a “moving target” in the early stage of development, where both its objectives and structure are not yet fully defined. From a Polish perspective, it has so far sent a key strategic message to Russia and can serve as a vehicle to re-engage with the United Kingdom or Turkey. But it should not be used as yet another ENP-style waiting room for candidates seeking EU membership.
The hydrogen policy of the Visegrad Countries. A comparative study
Authors: Marzec Justyna
Published: February 2024

The present paper aims to analyse and compare the preconditions for implementing hydrogen strategies in the Visegrad countries. This study attempts to verify that hydrogen policies are going to be implemented at different rates, thereby delaying their introduction. It is extremely important to assert this claim in the context of the energy crisis, the war in Ukraine, and the European Union’s aspirations to achieve low-carbon economy goals and energy self-sufficiency policies at both the national and EU levels. Furthermore, the study attempts to provide answers to the following research questions: firstly, does the hydrogen policy have a realistic chance of being implemented in the Visegrad region? Secondly, will it be implemented in the indicated form and extent of cooperation?
Geometria Não Euclidiana na formação do professor de matemática: oficinas de práticas matemáticas
Authors: Sousa Alexandre Pereira , Guerra Renato Borges , Nunes José Messildo Viana
Published: February 2024

Evidencia-se a necessidade da inserção de conteúdos relativos à Geometria Não Euclidiana na proposta curricular do Curso de Formação de Professores de Matemática. Nessa perspectiva, tem-se como objetivo, nesta pesquisa, propor Oficinas de Práticas Matemáticas, na formação de professores, para fomentar a inserção de assuntos da Geometria Não Euclidiana no currículo de cursos de licenciaturas em Matemática. Para levar a cabo essa proposição, desenvolveu-se uma pesquisa-ação com alunos do sétimo semestre da Licenciatura em Matemática do Instituto Federal de Educação, Ciência e Tecnologia do Maranhão. O quadro teórico adotado foi a Teoria Antropológica do Didático, que elenca ferramentas necessárias para o desenvolvimento de Oficinas de Práticas Matemáticas como dispositivo de formação de professores. O resultado aponta as oficinas como um dispositivo importante para inserir a Geometria Não Euclidiana na formação de professores de Matemática e fomentar a presença deste campo da geometria na proposta curricular do Curso de Formação de Professor de Matemática no Maranhão.
Noções geométricas nas aplicações de integrais definidas
Authors: Henriques Afonso , Almouloud Saddo Ag
Published: February 2024

Partindo da importância do cálculo diferencial e integral em matemática do ensino superior e referindo-nos à geometria plana, analítica e espacial como GEOPAES, colocamo-nos os seguintes questionamentos: Qual relação as aplicações de integrais definidas de funções reais de uma variável real tem com a GEOPAES? Como é que os estudantes do ensino superior lidam com esta relação na resolução de tarefas propostas? Buscar respostas para estas questões é o objetivo principal almejado neste capítulo. Para isso, recorremos à teoria dos registros de representação semiótica, assim como nas organizações didáticas locais propostas em livros de cálculo e de geometrias, culminando na análise de práticas de estudantes. Os resultados alcançados mostram que a relação está atrelada aos conceitos de medidas de áreas de regiões planas e de volume de sólidos, assim como de comprimentos de curvas, mobilizando-se objetos do saber conhecidos pelos estudantes nas instituições anteriores ao ensino superior. Contudo, estes revelam dificuldades com essa relação, que se manifestam na ausência da mobilização dos referidos saberes nos diferentes registros de representação semiótica evocados explicitamente no ensino e considerados nos geradores de tarefas propostas durante as avalições semestrais.
O estudo das cônicas em um grupo de professores do ensino básico: reflexões a partir de uma investigação com encontros virtuais síncronos e interações assíncronas
Authors: Oliveira Gerson Pastre de , Barbosa Yuri Osti
Published: February 2024

O presente artigo apresenta resultados de uma pesquisa qualitativa, com base na abordagem descritiva e interpretativa, e que foi realizada no âmbito de um grupo de professores de matemática do ensino básico. A investigação pretendeu analisar como a organização de um grupo de estudos com encontros virtuais pode concorrer para a revisita e aprofundamento da noção de cônicas, em termos do conhecimento didático e tecnológico do conteúdo. Para isso, são feitas descrições dos dois primeiros encontros e das interações assíncronas que ocorreram entre eles, o que permitiu identificar algum potencial para a formação de um grupo colaborativo, além de evidenciar a necessidade de formação continuada para superar as fragilidades relacionadas ao conteúdo matemático em tela. Os resultados indicam, também, que iniciativas de estudo continuado em ambientes virtuais devem levar em consideração as condições objetivas dos participantes, suas possibilidades e recursos para o acesso e participação efetiva.
Neuroprotective action of honey bee venom (melittin) against hypoxiainduced oxidative toxicity and cell death via inhibition of the TRPM2 channel
Authors: ERTİLAV Kemal
Published: February 2024

One bioactive element of honeybee venom is melittin (MEL). MEL induced oxidant and apoptotic activities through the increase of mitochondrial Zn2+ and Ca2+ in tumor cells, but it also induced neuroprotective activity by inhibiting the cell death, intracellular reactive oxygen species (iROS), and mitochondrial ROS (mROS) productions in neurons. By stimulating the TRPM2 channel, hypoxia (HPO) enhances the effects of oxidative stress and neuronal death; however, its inhibition prevents the alterations. I studied the neuroprotective effect of MEL on HPO-mediated oxidative neurotoxicity and cell death in SH-SY5Y neuronal cells by altering the TRPM2 signaling pathways. In the SH-SY5Y cells, five groups were induced as control, MEL (1 ug/ml for 24 hrs), HPO (CoCl2 and 200 M for 24 hrs), HPO + MEL, and HPO + TRPM2 antagonist (2-aminoethoxydiphenyl borate, 2APB) (100 M for 2 hrs). The amounts of cytosolic free Ca2+ were increased in the HPO group by the stimulation of hydrogen peroxide, although they were decreased in the cells by the treatment of 2APB and MEL. The amount of cytosolic free Ca2+ was higher in the HPO group than in the control group. The amounts of cell death (propidium iodide positive cell number), oxidants (mROS and iROS), mitochondrial membrane depolarization, and cytosolic free Zn2+ were higher in the HPO group than in the control and MEL groups, although their amounts were lower in the HPO + MEL and HPO + 2APB groups than in the HPO group only. In conclusion, MEL therapy reduced the amount of HPO-induced oxidative stress and neuronal deaths in SH-SY5Y cells by inhibiting TRPM2. The MEL could be considered as a potential protective component against oxidative neuronal damage caused by HPO.
A Nearly Finitary Matroid that is not $k$-Nearly Finitary
Authors: Tam Patrick
Published: February 2024

The class of $k$-nearly finitary matroids for some natural number $k$ is a subclass of the class of nearly finitary matroids. A natural question is whether this inclusion is proper. We answer this question affirmatively by constructing a nearly finitary matroid that is not $k$-nearly finitary for any $k \in \mathbb{N}$.
Wreath Products and Projective System of non-Schurian Association Schemes
Authors: Matsumoto Makoto , Ogawa Kento
Published: February 2024

A wreath product is a method to construct an association scheme from two association schemes. We determine the automorphism group of a wreath product. We show a known result that a wreath product is Schurian if and only if both components are Schurian, which yields large families of non-Schurian association schemes and non-Schurian $S$-rings. We also study iterated wreath products. Kernel schemes by Martin and Stinson are shown to be iterated wreath products of class-one association schemes. The iterated wreath products give examples of projective systems of non-Schurian association schemes, with an explicit description of primitive idempotents.
Does Forensic Accounting Matter? Diagnosing Fraud Using the Internal Control System and Big Data on Audit Institutions in Indonesia
Authors: Mardjono Enny Susilowati , Suhartono Entot , Hariyadi Guruh Taufan
Published: February 2024

This study aims to determine the relationship between awareness of the use of forensic accounting and the role of the internal control system (COSO) mediated by Big Data Analysis (BDA) towards interest in using forensic accounting in detecting fraud. The research design is a case study with a quantitative approach. The sample for this study was 331 auditor respondents spread across KAP, BPK and BPKP in Indonesia. The data used is primary data with research methods through interviews and surveys at the Indonesian auditor institutions. The weakness of companies is that on average they still use data systems that are not integrated, so there are risks in terms of data security. The results of this study prove that Big Data Analysis mediates the relationship between Awareness of Forensic Accounting on Intentions of Forensic Accounting. Also, Big Data Analysis mediates the relationship between COSO on Intentions of Forensic Accounting. The results show that the seventh hypothesis proposed is statistically proven. This study proves that the implementation of a good internal control system will be an effective tool to control fraud risk. Internal controls can be fully effective if the organization is able to understand the most vulnerable risks and how to respond to fraud. BDA with data mining techniques that contribute to decision-making and fraud detection. Auditors can find and extract hidden patterns in large amounts of data by using Big Data to detect fraud.
HUBUNGAN DUKUNGAN ORANG TUA DENGAN KARAKTER TOLERANSI SISWA MADRASAH IBTIDAIYAH
Authors: Widyaningsih Siti Faizah , Purnanto Arif Wiyat , Triana Putri Meinita , Mirawati Heti
Published: February 2024

The purpose of this research is to investigate the relationship between parental support and tolerance character among fifth-grade students at MI An Nuur Cahaya Umat. The issue at MI An Nuur Cahaya Umat indicates that the level of tolerance is still low. The subjects of this study consisted of 18 students. Data collection technique used a questionnaire. The data analysis technique employed was Pearson Product Moment with the assistance of IBM SPSS-26. The research findings indicate that the Pearson Correlation result is 0.145, which is categorized as low, with a significance result of 0.566, indicating a low correlation between parental support and tolerance character. Therefore, it can be concluded that parental support correlates lowly with the tolerance character of fifth-grade students at MI An Nuur Cahaya Umat.
Neue Konzepte zur Beseitigung von Gerüchen aus Röstanlagen mittels Fotooxidation/New concepts for eliminating odors from roasting systems using photooxidation
Authors: Seitz Frank
Published: February 2024

Plasmaverfahren (NTP) wie die Fotooxidation haben sich am Markt der Abluftreinigung etabliert. Besonders die Kombination verschiedenster Teilreinigungsschritte führt inzwischen dazu, dass eine Vielzahl von Emissionsminderungsaufgaben bei Röstprozessen energie- und rohstoffschonend umgesetzt werden können. Die Grundlagen und Techniken der Fotooxidation werden dargestellt. Ausgewählte Anwendungsbeispiele zeigen die Leistungsfähigkeit und -grenzen der Technologie auf.
Digital aufgestellt vom Klimaschutz bis zum Gefahrstoffmanagement
Authors: Hilse Annika
Published: February 2024

Obwohl hanseWasser mit 400 Mitarbeitenden nur zu den mittelgroßen Unternehmen der Abwasserbranche zählt, ist es dennoch ein Riese in Bezug auf die Nachhaltigkeit. Im Jahr 2011 begab sich hanseWasser auf die Reise in Richtung Klimaneutralität und schießt heute weit über dieses ursprüngliche Ziel hinaus. Was das Unternehmen anders macht, wie es zum Vorreiter für die Stadt Bremen und seine Branche wurde und welche aktuellen Herausforderungen und Pläne anstehen, erklären uns Tanja Schmellenkamp-Winter, Stab Organisation und Rechtskonformität, sowie Jana Küffner Nachhaltigkeitsbeauftragte, im Interview. Erfahren Sie im Gespräch, warum und wie hanseWasser ein integriertes Managementsystem führt, das sämtliche Akteure und Aktivitäten im Bereich Arbeitsschutz, Qualitätsmanagement und Umweltschutz zusammenbringt.
Security Orchestration, Automation and Response (SOAR)
Authors: Weil Ramon
Published: February 2024

Risikobewusste Unternehmen haben in der Regel mehrere IT-Sicherheitslösungen im Einsatz, um ihre Organisation vor Cyberbedrohungen zu schützen. Auch wenn die einzelnen Tools optimal funktionieren – sie arbeiten nicht unbedingt zusammen. Aufgrund begrenzter Ressourcen und dem Mangel an verfügbaren Fachkräften besteht für viele Unternehmen die besondere Herausforderung, mit dieser Entwicklung Schritt zu halten. Aus diesem Grund hat die Weiterentwicklung von Security Orchestration, Automation and Response (SOAR) deutlich an Fahrt aufgenommen. Der Beitrag zeigt, wie SOAR-Systeme die Cybersicherheit revolutionieren.
Alternative Brandschutzkonzepte
Authors: Rothe Rajko , Langstrof Alexandra
Published: February 2024

Normativ festgelegte Maßnahmen des vorbeugenden, vor allem des baulichen Brandschutzes sind oft nicht sinnvoll umsetzbar. Die angestrebten Schutzziele sind dann nicht erreichbar. Vor allem in komplexen Situationen, wie z. B. in Baudenkmälern, großen Versammlungsstätten oder bei neuartigen Brandrisiken wie Lithium-Ionen-Batterien sind gute Schutzkonzepte notwendig. Mithilfe ingenieurwissenschaftlicher Methoden kann der Nachweis gleicher Sicherheit geführt werden. Anwendungsbeispiele zeigen, wie sich dieser nach dem aktuellen Stand des Brandschutzingenieurwesens führen lässt.
Understanding Trends in Health Communication and Appropriate Design for Outstanding Research Outcome in Nigeria
Authors: Igben Harvey G.O. , Enebeli Lucas Madubuchukwu
Published: February 2024

This study evaluated the frequency of health communication issues published in Journal of Communication and Media Research (JCMR) as a percentage of the total publications, the dominant themes on health communication in the JCMR and the dominant research designs used in the studies on health communication in the JCMR. A qualitative research design was employed in this study with survey of literature in the JCMR. The study found that the average coverage of health communication by health communication scholars in JCMR. was the predominant thematic area of health communication covered by JCMR. It established that the theme of assessment and evaluation of health interventions and campaigns and the theme of Doctor-Patient Communication is the lowest area of attention. This can be justified by the fact that it is relatively a new area of health communication research in Nigeria. It was discovered that majority of researchers did not specify the research design employed in the various articles in JCMR while case study research was the dominant design that scholars used in JCMR.
Impact of Social Capital on Poverty Reduction in Benue State Nigeria
Authors: Shiaki Tsokwa Kweseti , Almakura Faisal Ahmed , Gambo Nasamu , Abubakar Hauwa Lamino
Published: February 2024

Benue State comprises diverse communities, each facing unique socio-economic challenges including poverty. This study examined the impact of social capital on poverty reduction in Benue State, Nigeria. A survey research design was adopted for the study. Primary data was collected from 6 Local Government Areas of Benue State. Logit binary regression analysis was used to estimate variables used in the study in relation to its effect on poverty reduction. All variables tested improved Benue state poverty except political party membership and involvement. The results revealed that cooperative society participation, social media involvement, rural group membership, and social club membership has the tendency to reduce poverty by 50% to 68% in Benue State. Overall, with an R-square value of 0.870, there is a strong positive linear relationship between the variables. Social capital may reducepoverty based on community trust, social connection, and socioeconomic context. Addressing inequalities and distributing incentives equitably is crucial to improving social capital.
Gambaran Makna Hidup Pada Mantan Wanita Tuna Susila
Authors: Dwiana Maya Asmaradewi
Published: February 2024

Perkembangan kehidupan manusia tidak selamanya berjalan dengan baik sesuai yang diharapkan. Manusiadalam kehidupannya sering menemui kendala yang membuat manusia merasa kecewa dan tidakmenemukan jalan keluar sehingga manusia memilih langkah yang kurang tepat dalam jalan hidupnya.Salah satu jalan pintas dalam perjalanan hidup seorang perempuan akibat cobaan-cobaan hidup yang beratdirasakan, perempuan tersebut terjun didalam dunia pelacuran. Kehidupan wanita tuna susila berjalan tidaksesuai dengan norma yang berlaku di masyarakat. Hal ini menarik peneliti untuk melakukan penelitianmengenai gambaran makna hidup mereka. Peneliti menggunakan metode penelitian kualitatif dengan teknikwawancara sebagai metode utama dan observasi sebagai metode tambahan selama wawancara berlangsung.Peneliti mengambil tiga subjek yang merupakan mantan wanita susila, peneliti melakukan analisis kepadatiga orang subjek tersebut. Hasil penelitian menemukan bahwa ketiga subjek tersebut merasakan maknahidup didalam kehidupannya yang dijalani. Dengan demikian, hampir semua subjek penelitian memilikipikiran positif mengenai kehidupannya masa sekarang dan masa depannya. Untuk penelitian selanjutnyadiharapkan subjek dapat lebih diperbanyak dan dipeluas cakupannya, observasi juga digunakan sebagaimetode utama dalam pengambilan data. Penelitian berikutnya akan lebih baik jika turut menggali kakterpositif yang dimiliki subjek guna mengetahui lebih lanjut makna hidup tentang subjek.
FORMULATION AND CHARACTERIZATION OF ANTI-INFLAMMATORY TRANSDERMAL PATCH PREPARATIONS FROM THE EXTRACT OF PATAH TULANG (Euphorbia tirucalli)
Authors: Sutiswa Shandra Isasi , Saripah Syipa Siti , Martihandini Nooryza
Published: February 2024

Transdermal patches are pharmaceutical preparations that aim to provide a drug delivery system across the surface of the skin and tissue, which is then delivered to the blood. is a plant that contains secondary metabolites with anti-inflammatory activity, such as alkaloids, flavonoids, polyphenols, tannins, steroids, and saponins. This study aimed to determine the characteristics of anti-inflammatory transdermal patch preparations prepared from Euphorbia tirucalli extract. The research method was laboratory experimental by preparing patches using varying concentrations of Euphorbia tirucalli extract, namely F1 (5%), F2 (10%), and F3 (15%). Next, an evaluation of patch preparation was carried out, including organoleptic tests, weight uniformity tests, thickness tests, fold durability tests, pH tests, and moisture tests. From the research results, it can be concluded that Euphorbia tirucalli extract at concentrations of 5%, 10%, and 15% can be made into patch preparations. The best characteristics of the patch preparation were F2 with an extract concentration of 10%, which had a smooth, flexible texture, folding durability >300 folds, pH 4.5, and moisture value of 7.30%.
 Keywords: Anti-inflammatory, Euphorbia tirucalli, Transdermal patch
HUBUNGAN KEPUASAN KERJA, MOTIVASI KERJA, DISIPLIN KERJA DAN LAMA KERJA DENGAN PRODUKTIVITAS KERJA PADA PDKB PT. PLN (PERSERO) UP3 KENDARI
Authors: Andini Meisya , Asfian Pitrah , Dewi Sri Tungga
Published: February 2024

PT PLN UP3 Kendari merupakan unit di bawah PLN Unit Induk wilayah Sulselbar yang berfungsi memberi pelayanan listrik kepada masyarakat dalam bekerja, Pekerja dituntut untuk menyadari pentingnya kepuasan, disiplin, motivasi dan lama kerja guna meningkatkan produktivitas, terkait dengan produktivitas kerja yang dirasakan karyawan mengatakan bahwa 6 pekerjaan yang menimbulkan tantangan sangat berpengaruh terhadap kinerja. Tujuan penelitian adalah untuk mengetahui dan menganalisis hubungan antara kepuasan kerja, disiplin kerja, motivasi kerja serta lama kerja dengan produktivitas kerja pada pekerjaan bagian pekerjaan dalam keadaan bertegangan (PDKB) di PT. PLN UP3 Kendari. Pada penelitian ini jenis metode yang digunakan adalah kuantitatif observasional dengan menggunakan pendekatan studi potong lintang (Cross Sectional Study), sampel dalam penelitian Ini berjumlah 34 dengan teknik total sampling dimana seluruh populasi dijadikan sebagai sampel penelitian serta uji statistik yang digunakan yaitu uji chi-square. Hasil dari penelitian ini menunjukkan bahwa analisis uji hubungan antara masing-masing variabel independen dengan produktivitas kerja menunjukkan kepuasan kerja memiliki nilai p 0,340; motivasi kerja 0,000; disiplin kerja 0,000; lama kerja 0,046. Maka kesimpulan penelitian adalah ada hubungan antara motivasi dan disiplin kerja dengan produktivitas kerja pekerja di bagian Pekerjaan dengan Keadaan Bertegangan (PDKB) di PT. PLN (Persero) UP3 Kendari. Tidak ada hubungan kepuasan kerja dan lama kerja dengan produktivitas kerja pekerja di bagian Pekerjaan dengan Keadaan Bertegangan (PDKB) di PT. PLN (Persero) UP3 Kendari.

Kata kunci: disiplin, kepuasan, lama kerja, motivasi, produktivitas
GAMBARAN KUALITAS SEL DARAH PADA PETUGAS OPERATOR STASIUN PENGISIAN BAHAN BAKAR UMUM (SPBU) SAMPARA KABUPATEN KONAWE TAHUN 2022
Authors: Musdalifah Siti , Jafriati Jafriati , Azim La Ode Liaumin
Published: February 2024

Pekerja SPBU sangat berisiko terpapar zat berbahaya masuk ke sistem pernafasan. Manusia sebagian besar terpapar benzena melalui pernapasan, tetapi pekerja SPBU dapat terpapar benzena tingkat tinggi saat mengisi bensin. Tujuan penelitian ini adalah untuk memberikan gambaran kualitas sel darah di SPBU Sampara Kabupaten Konawe tahun 2022. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan pendekatan kuantitatif deskriptif. Populasi penelitian adalah operator SPBU, sedangkan sampel penelitian adalah 11 operator SPBU di Sampara Kabupaten Konawe. Teknik penentuan sampel menggunakan teknik total sampling. Intrumen penelitian yang digunakan dalam penelitian ini adalah kusioner, kamera atau handphone, dan alat tulis. Berdasarkan temuan penelitian, hasil pemeriksaan kadar eritrosit normal tertinggi diperoleh dari 10 subjek (90,9%). frekuensi hasil pemeriksaan kadar eritrosit abnormal terendah berasal dari 1 subjek (9,1%). Untuk pemeriksaan kadar leukosit didapatkan jumlah normal tertinggi dari 10 subjek (90,9%) untuk trombosit dan 1 subjek (9,1%) untuk hemoglobin. Berdasarkan hasil penelitian juga diketahui, kadar eritrosit tertinggi adalah 9,65 juta/l dan terendah 3,57 juta/l; leukosit tertinggi 9.600/l dan terendah 3.500/l; kadar trombosit tertinggi 435.000/l dan terendah 241.000/l; dan kadar hemoglobin tertinggi 16,8/dL dan terendah 11,5/dL. Kesimpulan penelitian menunjukkan kadar eritrosit normal sebanyak 1 orang dan yang tidak normal sebanyak 10 orang, sedangkan pemeriksaan kadar leukosit normal 10 orang dan tidak normal 1 orang, pemeriksaan kadar trombosit yang normal sebanyak 10 orang dan yang tidak normal sebanyak 1 orang, hasil pemeriksaan kadar hemoglobin normal sebanyak 10 orang dan yang tidak normal sebanyak 1 orang.

Kata kunci: paparan benzene, petugas SPBU, sel darah
A Forest Nenets text about the Дяӈ ката ritual doll
Authors:   Kharampur village School Yamalo-Nenets Autonomous Okrug, Russia, Yavid Valentina , Kozlov Aleksey ,   Institute of Linguistics of the Russian Academy of Sciences, Moscow, Russia,   Higher School of Economics University, Moscow, Russia, Aristova Мaria ,   Higher School of Economics University, Moscow, Russia,   Letovo School  Moscow, Russia
Published: February 2024

This article presents a text in the Pur dialect of the Forest Nenets language. The text has to do with the traditional ritual doll of the For‑ est Nenets – Дяӈ ката, ‘Grandmother of the Earth’. The text’s author is a native speaker of Forest Nenets, and its publication was prepared in col‑ laboration with linguists. The text is accompanied by a Russian transla‑ tion and interlinear morpheme-by-morpheme glossing. The orthograph‑ ic system used for transcribing the text is introduced in the preface. Linguistic phenomena that have previously not been sufficiently de‑ scribed for the Forest Nenets language are commented on in footnotes.