bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of AHSA1 as a Potential Therapeutic Target for Breast
Cancer: Bioinformatics Analysis and in vitro Studies
Authors: Zhao Hong , Lu Jin-Jian , Shi Wei , Qi Lu , You Xiong-Bin , Chen Yu-Chi , Xu Yu-Lian , Yu Wei-Bang , Huang Mu-Yang
Published: January 2022

Background:

Shenling Baizhu Powder (SBP), a famous Traditional Chinese Medicine
(TCM) formulation, has been widely used in the adjuvant treatment of cancers, including breast
cancer. This study aims to identify potential new targets for breast cancer treatment based on the
network pharmacology of SBP.

Methods:

By analyzing the relationship between herbs and target proteins, potential targets of multiple
herbs in SBP were identified by network pharmacology analysis. Besides, by comparing the
data of breast cancer tissue with normal tissue, upregulated genes in two breast cancer expression
profiles were found. Thereafter, the expression level and prognosis of activator of heat shock protein
90 (HSP90) ATPase activity 1 (AHSA1) were further analyzed in breast cancer by bioinformatics
analysis, and the network module of AHSA1 binding protein was constructed. Furthermore, the
effect of knocking down AHSA1 on the proliferation, migration, and invasion of breast cancer
cells was verified by MTT, clone formation assay, and transwell assay.

Results:

Vascular endothelial growth factor A (VEGFA), intercellular adhesion molecule 1 (ICAM1),
chemokine (C-X-C motif) ligand 8 (CXCL8), AHSA1, and serpin family E member 1
(SERPINE1) were associated with multiple herbs in SBP. AHSA1 was remarkably upregulated in
breast cancer tissues and positively correlated with poor overall survival and disease metastasis-
free survival. Furthermore, knockdown of AHSA1 significantly inhibited the migration and invasion
in MCF-7 and MDA-MB-231 breast cancer cells but had no obvious effect on proliferation.
In addition, among the proteins that bind to AHSAl, the network composed of proteasome, chaperonin,
and heat shock proteins is closely connected, and these proteins are associated with poor prognosis
in a variety of cancers.

Conclusion:

AHSA1 is positively correlated with breast cancer progression and might act as a novel
therapeutic target for breast cancer.
Identification of Anticancer and Anti-inflammatory Drugs from Drugtarget
Interaction Descriptors by Machine Learning
Authors: Huang Songtao , Ding Yanrui
Published: January 2022

Background:

Drug repositioning is an important subject in drug-disease research. In the past,
most studies simply used drug descriptors as the feature vector to classify drugs or targets or used qualitative
data about drug-target or drug-disease to predict drug-target interactions. These data provide limited
information for drug repositioning.

Objective:

Considering both drugs and targets and constructing quantitative drug-target interaction descriptors
as a method of drug characteristics are of great significance to the study of drug repositioning.

Methods:

Taking anticancer and anti-inflammatory drugs as research objects, the interaction sites between
drugs and targets were determined by molecular docking. Sixty-seven drug-target interaction descriptors
were calculated to describe the drug-target interactions, and 22 important descriptors were
screened for drug classification by SVM, LightGBM, and MLP.

Results:

The accuracy of SVM, LightGBM, and MLP reached 93.29%, 92.68%, and 94.51%, their Matthews
correlation coefficients reached 0.852, 0.840, and 0.882, and their areas under the ROC curve
reached 0.977, 0.969, and 0.968, respectively.

Conclusion:

Using drug-target interaction descriptors to build machine learning models can obtain better
results for drug classification. Number of atom pairs, force field, hydrophobic interactions, and bSASA
are the key features for classifying anticancer and anti-inflammatory drugs.
COL1A1 as a Potential Prognostic Marker and Therapeutic Target in
Non-small Cell Lung Cancer
Authors: Pan Boyu , Huang Chen , Xia Yafei , Zhang Cuicui , Li Bole , Wang Liangjiao , Fang Senbiao , Liu Liren , Yan Shu
Published: January 2022

Background:

Nowadays, non-small cell lung cancer (NSCLC) is a common and highly fatal
malignancy worldwide. Therefore, identifying the potential prognostic markers and therapeutic targets is
urgent for patients.

Objective:

This study aimed at finding hub targets associated with NSCLC using multiple databases.

Methods:

Differentially expressed genes (DEGs) from Genome Expression Omnibus (GEO) cohorts
were employed for the enrichment analyses of Gene Ontology (GO) terms and the Kyoto Encyclopedia
of Genes and Genome (KEGG) pathways. Candidate key genes, filtered from the topological parameter
'Degree' and validated using the Cancer Genome Atlas (TCGA) cohort, were analyzed for their association
with clinicopathological features and prognosis of NSCLC. Meanwhile, immunohistochemical cohort
analyses and biological verification were further evaluated.

Results:

A total of 146 DEGs were identified following data preprocessing, and a protein-protein interaction
(PPI) systematic network was constructed based on them. The top ten candidate core genes were
further extracted from the above PPI network by using 'Degree' value, among which COL1A1 was
shown to associate with overall survival (OS) of NSCLC as determined by using the Kaplan-Meier analysis
(p=0.028), and could serve as an independent prognostic factor for OS in NSCLC patients (HR,
0.814; 95% CI, 0.665-0.996; p=0.046). We then analyzed the clinical stages, PPI, mutations, potential
biological functions, and immune regulations of COL1A1 in NSCLC patients using multiple bioinformatics
tools, including GEPIA, GeneMANIA, cBioPortal, GESA, and TISIDB. Finally, we further experimentally
validated the overexpression of COL1A1 in NSCLC samples and found that inhibition of
COL1A1 expression moderately sensitized NSCLC cells to cisplatin.

Conclusion:

Thus, our results showed that COL1A1 may serve as a potential prognostic marker and
therapeutic target in NSCLC.
An Intercultural Approach to English Language Teaching
Authors: Corbett John
Published: January 2022

This is a thoroughly revised, updated and expanded edition of a practical introduction to intercultural education for teachers of English as a second language. This new edition addresses developments in the field since the publication of the 1st edition, including the impact of online resources for English language education.
Evaluación agronómica y valor nutritivo de avena (Avena sativa) bajo condiciones de restricción de lluvia en los Andes
Authors: Arango Quispe Sheyla Johanna Shumyko , Viera Valencia Mario , Gómez Bravo Carlos Alfredo
Published: January 2022

La avena es un cereal de alto valor nutritivo para humanos y animales. El objetivo del estudio fue caracterizar agronómicamente ocho genotipos de avena en respuesta a la restricción de lluvia. Se realizó en los Andes centrales del Perú mediante un diseño completamente al azar con arreglo factorial ocho genotipos de avena forrajera (INIA901 Mantaro15, INIA902 Africana, INIA903 Tayco, Junín-Jauja blanca, Centenario, Junín-Tarma negra, Junín-Jauja negra y Cayuse) con 0 % y 60 % de restricción de lluvia y tres repeticiones. Se tuvieron 48 unidades experimentales (parcelas de 4,8 metros cuadrados), donde la restricción de lluvia se logró a través de interceptores de lluvia. Se encontró a una confianza del 95 % que no existe interacción entre los genotipos de avena y la restricción de lluvia. La restricción de lluvia afectó al rendimiento (ton MS/ha) disminuyéndolo de 4,3 ± 0,7 a 3,0 ± 1,0, y al porcentaje de proteína cruda aumentándolo de 12,7 ± 3,1 a 17,0 ± 2,7. No se encontró efecto significativo de la restricción de lluvia sobre la  fibra detergente neutro, la cual fue de 41,1 ± 1,8 % para el nivel sin restricción y 41,3 ± 3,2 % para el nivel con restricción; ni sobre la digestibilidad in vitro aparente de la materia orgánica que fue de 71,5 ± 15,3 % para el nivel sin restricción y de 67,8 ± 15,4 % para el nivel con restricción. Los genotipos que mejor resisten la sequía son Junín-Jauja negra y Centenario.
Foodborne Outbreak Investigation in Al-Ahsa, Saudi Arabia, 2021: A Retrospective Cohort Study
Authors: Alahmad Abdulmohsen , Kamel Shady Abdulrahman
Published: January 2022

Background

On September 10, 2021, Al-Ahsa General Health Directorate reported an unexpected number of patients had presented with gastrointestinal symptoms. All the patients gave a history of sharing a common meal as they ate dinner that was served at the mother’s house in a family gathering on September 9, 2021, at 9 PM in Al-Ahsa.

Objective

This study aims to confirm the existence of the outbreak, confirm the diagnosis, define and identify the cases, identify the source of the outbreak, determine the causative agent or organism if possible and its mode of transmission, and recommend preventive measures to be applied to prevent similar outbreaks in the future.

Methods

A retrospective cohort design was used in this outbreak investigation to identify its source. Cases were defined as any person who ate dinner at the family gathering on September 9, 2021, and developed any or a combination of the following symptoms: diarrhea, vomiting, fever, or abdominal pain within 26 hours of food consumption. We collected information on demographics, symptoms, and food history using a semistructured questionnaire. We reviewed hospital records for symptoms and vital signs. We reviewed available laboratory results for cases, and we conducted an active case search to identify more cases. The data obtained was analyzed using SPSS version 21.0 (IBM Corp).

Results

A total of 20 (74%) were defined as cases and 7 (26%) as noncases. Of 20 cases, 16 (80%) were females and 4 (20%) were males. The ages ranged between 2-70 years. Among cases, 59.3% had vomiting, 59.3% had a fever, 48.1% developed diarrhea, and 25% had abdominal pain. The incubation period ranged from 10 to 26 hours, with a mean of 17.8 hours. The risk ratios (relative risks) and P values were calculated for each food item to assess the association between consumption of individual food items and subsequent illness. Among 8 food items consumed, red pasta with chicken (relative risk 37.3, 95% CI 3.2-424.6) and beef pizza (relative risk 6.5, 95% CI 1.74-42.2) were significantly associated with illness.

Conclusions

According to the epidemiological investigation, symptoms, incubation period, and laboratory results, there might be some differential diagnosis, but we were unable to more definitively identify the source of the outbreak. We recommend more education to the households about food safety.
Mitigating Aircraft Auxiliary Power Unit Carbon Dioxide (CO2) Emissions During the Aircraft Turnaround Process from the Use of Solar Power at the Airport Gate: The Case of Moi International Airport, Kenya
Authors: Baxter Glenn
Published: January 2022

One of the most pervasive trends in the global airport industry in recent times has been the adoption of green renewable technologies. Many airports around the world have now installed photovoltaic (PV) solar systems as a key environmental measure. One of the critical areas of energy management at an airport is the provision of power and cooling at the gate, which is used during the aircraft turnaround process. Historically, the aircraft auxiliary power unit (APU) was the primary power source during the aircraft turnaround process. In recent times, airports have transitioned to the use of fixed electrical ground power (FEGP) and preconditioned air to mitigate the emissions from use of aircraft auxiliary power unit (APUs). Based on an instrumental case study research approach, this study has examined how Moi International Airport in Kenya has mitigated the airport’s carbon footprint by using a green, renewable energy system. The study’s qualitative data was examined by document analysis. The case study revealed that Moi International Airport has installed a photovoltaic (PV) solar system with a 500kW capacity that is used to primarily provide solar power at the airport’s apron area. The photovoltaic (PV) solar system has delivered Moi International Airport with an important environmental related benefit as it has enabled the airport to reduce it carbon footprint, as the photovoltaic (PV) solar system has reduced the airport’s carbon dioxide (CO2) emissions by an estimated 1,300 tonnes per annum.
A deep learning approach to diagnose atelectasis and attic retraction pocket with otoscopic images
Authors: Zeng Junbo , Deng wenting , Yu Jingang , Xiao Lichao , Chen Suijun , Zhang Xueyuan , Zeng Linqi , Chen Donglang , Li Peng , Chen Yubin , Zhang Hongzheng , Shu Fan , Gao Jinliang , Wu Minjian , Su Yuejia , Li Yuanqing , Cai Yuexin , Zheng Yiqing
Published: January 2022

Background: Atelectasis and attic retraction pocket are two common
tympanic membranes changes. However, general practitioners,
pediatricians and otolaryngologists showed low diagnostic accuracy for
these ear diseases. Therefore, there is a need to develop a deep
learning model to detect atelectasis and attic retraction pocket
automatically. Method: 6393 OME otoscopic images from 3 centers were
used to develop and validate a deep learning model to detect atelectasis
and attic retraction pocket. 3-fold random cross validation was adopted
to divided dataset into training set and validation set. A team of
otologists were assigned to diagnose and label. Receiver operating
characteristic (ROC) curve, 3-fold average classification accuracy,
sensitivity and specificity were used to assess the performance of deep
learning model. Class Activation Mapping (CAM) was applied to show the
discriminative region in the otoscopic images. Result: Among all the
otoscopic images, 3564 (55.74%) images were identified with attic
retraction pocket, and 2460 (38.48%) images were identified with
atelectasis. The automatically diagnostic model of attic retraction
pocket and atelectasis achieved 3-fold cross validation accuracy of 89%
and 79%, AUC of 0.89 and 0.87, sensitivity of 0.93 and 0.71, and
specificity of 0.62 and 0.84 respectively. Bigger and deeper atelectasis
and attic retraction pocket showed more weight with red color in the
heat map of CAM. Conclusion: Deep learning algorithm could be used to
identify atelectasis and attic retraction pocket, which could be used as
a tool to assist general practitioners, pediatricians and
otolaryngologists. Key words: deep learning, otoscopic images,
atelectasis, attic retraction pocket
THE PROJECT METHOD AS A TOOL OF EFFECTIVE TEACHING A FOREIGN LANGUAGE IN DISTANT AND MIXED LEARNIN
Authors: Didkivska Iuliia
Published: January 2022

The aim of this paper is to prove the hypothesis that the application of project methods in foreign language lessons shows that students achieve good results in learning a foreign language, have a practical opportunity to apply the skills acquired in computer science lessons. The main advantages of the project method are: increasing the motivation of students in learning English, visual integration of knowledge in different subjects, space for creative activity. A project is an opportunity for students to express their own ideas in a creative form that is convenient for them: making collages, announcements, conducting interviews and research etc. The most important thing is that the child, not the teacher, determines what the project will contain, in what form and how it will be presented. Achieving the goal of the project is subject to all actions developed by students and teachers: the study of the necessary lexical and grammatical units, search for sources of information, selection of the necessary information, design and presentation of results. In teaching foreign languages, the project method allows students to use the language in real-life situations, which contributes to better learning and consolidation of foreign language skills. Methods used in the study: general scientific (analysis and synthesis, induction and deduction), methods of theoretical research (from abstract to concrete), historical method.
“FICTIONAL BIOGRAPHIES OF JOSEF KNECHT THROUGH THE PRIZM OF TRANSPERSONAL PSYCHOLOGY (BASED ON HERMAN HESSE'S NOVEL“THE GLASS BEAD GAME”)
Authors: Megela Ivan , Mehela Kateryna
Published: January 2022

The article focuses on three biographies of Josef Knecht from the novel by Hermann Hesse “The Glass Bead Game” with regard to the postulates of transpersonal psychology. A thorough study provides insight into the peculiarities of a unique literary technique – the transfer of the “self” into different historical periods by means of imagination, as a kind of “way to self”, devotion to truth through pagan voluntary sacrifice (“Rainmaker”), the ascetic self-denial of a Christian schemamonk (“The Father Confessor”), the life of an Indian ascetic (“Siddhartha”), understanding that all being is illusionary. The research highlights the similarity of plot events, names, integration of esoteric and exoteric perspectives. The study reviews a holotropic state of consciousness, which can develop into psychoid experience, accounting for the impossible to become possible. Based on the judgments of the direct relationship between the concepts of the macrocosm and the microcosm, the perception of reality as a result of human intellectual activity, it is specified that the efforts of the “possible human”, “virtual human” to liberate themselves from the dualistic perception of reality is accomplishable by acquiring the unity of consciousness. The authors point out that the review of the motive of “awakening” indicates Hesse’s intention to embody absolute transcendent reality in his characters, which could manage the crisis of splitting consciousness.
THE PROGRAM OF DEVELOPMENT OF PSYCHOLOGICAL PREPAREDNESS OF MILITARY SERVANTS OF AIRBORNE ASSAULT FORCES OF THE ARMED FORCES OF UKRAINE TO ACTIVITIES IN BATTLES
Authors: Kyrychenko Andrii
Published: January 2022

The article reveals the main tasks, purpose, content and structure of the program for the development of psychological readiness of servicemen of the Airborne Assault Forces of the Armed Forces of Ukraine to work in combat conditions "Born – to win" (hereinafter the program). The purpose of the program is not only to provide servicemen of Airborne Assault Forces with knowledge of psychological readiness, functioning of the body in extreme conditions and practical skills of self-regulation, but also to optimize the process of psychological readiness of paratroopers in combat. The main objectives of the program are: development of the motivational sphere, psychological readiness of servicemen for service and combat activities; acquaintance with the concepts of "psychological readiness", "psychological stability", "traumatic factors of modern combat", "preservation of mental health"; formation of a positive attitude to oneself, to the chosen profession, understanding and representation of servicemen's own actions on the battlefield, forecasting possible dangerous situations and making timely and correct decisions to overcome them; formation and development of skills and practical skills necessary for first aid, self-regulation and self-control of emotional state. Paratroopers enrich their professional experience, form and develop skills and abilities necessary to perform tasks on the battlefield in conditions of danger, uncertainty and suddenness, realize their own characteristics (know themselves), improve practical skills of first aid, self-regulation and self-control of emotional state. According to the results of the program is an effective tool for developing the psychological readiness of servicemen of the Airborne Assault Troops of the Armed Forces of Ukraine.
PROBLEMS OF CONFLICT OF INTEREST MANAGEMENT IN THE CIVIL SERVICE SYSTEM
Authors: Likarchuk Natalia , Likarchuk Daria , Shevel Inna
Published: January 2022

We offers a solution to problems of conflict of interest management in the civil service system. Conflicts of interest are largely provoked by the implementation of a radical domestic policy of reforms that affect the fundamental interests of most actors in political life. It is in these crisis conditions of “institutional instability” that the articulated interests of the main groups in the struggle to preserve or change their political status are especially evident. The conflict of interests of the ruling elite is resolved by the new strategic course development by the political leadership of the state, which finds its expression in the institutionalization of the political regime within the policy of “consensus”. Ukraine implements the European experience and uses international cooperation of developed democracies to study and prevent conflicts of interest, implement international standards, settle political and legal mechanisms to overcome the negative consequences of conflicts in the civil service.
COOPERATION BETWEEN THE MEMBERS OF THE EUROPEAN UNION IN PROTECTION OF CULTURAL VALUES
Authors: Shulha Viktoriia
Published: January 2022

In the provisions of the scientific article, the author analyzes the formation of cooperation between the Member States of the European Community in the field of protection of cultural property since the introduction of the single European market in 1993 and to the present day. This study presents the formation of cooperation in the field of export of cultural values. It was found that special control has been established, and the criteria for issuing licenses for the export of cultural property are the items’ age and value. Particular attention is paid to the peculiarities of legal regulation and cooperation in the field of return of cultural objects illegally moved from the territory of an EU member state. It is determined that in order to combat the illicit trafficking of cultural property, the current legislation has expanded opportunities for cooperation and exchange of information between Member States. Greater emphasis is placed on the development of cooperation in the field of import of cultural values from non-EU countries, which provides for the creation of a centralized electronic database of imported cultural values.
Entrevista
Authors:   Unidade de Saúde e Performance da Federação Portuguesa de Futebol. Lisboa, Brito João
Published: January 2022

“... Na Unidade de Saúde e Performance da FPF procuramos trabalhar em equipas multidisciplinares, no sentido de garantir bons serviços clínicos e apoio nas áreas complementares das Ciências do Desporto. Procuramos integrar estes serviços, orientando-os para o rendimento desportivo... Procuramos que a investigação desenvolvida decorra em colaboração com centros de investigação nacionais e internacionais. Temos o futebol como objeto de estudo e procuramos essencialmente desenvolver investigação aplicada nas áreas da saúde e performance desportiva. ... Com a criação da Portugal Football School procurou-se que a formação se alargasse a todas as áreas e intervenientes no futebol. No que respeita à formação em áreas clínicas, temos procurado divulgar, num modelo de cascata, as orientações do UEFA Football Doctor Education Programme. Para tal, temos tido uma parceria extraordinária com a Faculdade de Medicina da Universidade do Porto no âmbito dos cursos de especialização em Medicina do Futebol, ...”
Epicondilalgia Lateral: Conceitos, Avaliação e Tratamento
Authors:   Clínica Espregueira – FIFA Medical Centre of Excellence, Porto, Gismonti André , Andrade Renato , Barros Luís Henrique , Valente Cistina , Espregueira-Mendes João ,   Clínica Espregueira – FIFA Medical Centre of Excellence, Porto
Published: January 2022

Lateral epicondylalgia, also popularly and formerly known as tennis elbow, is the most prevalent elbow pathology in adult population, including professional and recreational athletes, especially in handgrip activities. Due to its predominant incidence, the understanding of its etiopathogenesis and therapeutic approaches have been recently more widely investigated, with concepts currently better defined and new therapies showing better prognosis and providing early rehabilitation to physical activities. This article aims to explore these concepts, contemplating the most up-to-date treatments for this condition.
A patologia mental em atletas e a psiquiatria desportiva
Authors:   Hospital de Magalhães Lemos, EPE. Porto, Sousa Martins António
Published: January 2022

Mental disease in elite athletes is common, affecting their sports performance, as well as other parts of their life. Sports psychiatry is a medical subspecialty dedicated to the study of psychiatry in this specific population. The aim of this paper is to summarize the most common mental diseases in athletes, as well as their similarities and differences with the general population. The role of the sports psychiatrist within a multidisciplinary team that addresses mental health and illness in athletes will also be discussed.
SPMD - Resumos da Sports Medicine Summit (nov) 2021
Authors:   Sociedade Portuguesa de Medicina Desportiva, Tomás Rita , Dores (1) Hélder ,   Hospital da Luz, Sport Lisboa e Benfica, Lisboa., Rebelo-Marques (2) Alexandre ,   Faculdade de Medicina, Universidade de Coimbra
Published: January 2022

Two roundtables: 1. COVID-19 and Sports: Lessons Learned and Future Directions 2. E-Sports Medicine
Bioconversion of molesses to ethanol by reactive yeast
Authors:   Lviv Polytechnic National University, Palianytsia L. Ya. , Berezovska N. I. ,   Lviv Polytechnic National University
Published: January 2022

The process of fermentation of beet molasses to ethanol using dry alcohol yeast Deltaferm AL-18, reactivated in wort with different dry matter content was studied. It is shown that the fermentative activity of these yeasts is higher than the generative one. The concentration of ethanol in the brew is maximum under the condition of reactivation of yeast in the wort (22 % CF). The density of yeast after fermentation decreases proportionally if the yeast is activated in the wort with a higher concentration.
The Different Facets of Injustice
Authors: Chibber Vivek , Veneziani Roberto
Published: January 2022

In her recent work, Nancy Folbre (2020, 2021) undertakes an ambitious effort: constructing an intersectional political economy that aims to identify the common mechanisms and logic underpinning the many wrongs that characterise capitalism. In this paper, we focus on what we deem the three fundamental theoretical pillars of her approach. First, she challenges the oppression/exploitation distinction within Marxian political economy and proposes a broader definition of exploitation that can take manifold forms. Second, she questions the Marxian concept of class, and emphasises the variety of forms of subordination and exploitation related to social identities that cannot be reduced to Marxian classes. Finally, she advocates a more comprehensive notion of the economy beyond a focus on capitalist relations of production. It is difficult to understate the theoretical relevance of these claims, which highlight the importance of various contemporary forms of injustice—of which the exploitation of workers by capitalists is only one. As a complement to the Marxian theory of exploitation and class, Folbre’s approach would broaden our understanding of oppressive social relations. Yet as an alternative to Marxian political economy, it is ultimately unconvincing: a shift of emphasis to ‘manifold exploitations’, social groups, and the economy does not yield a gain in analytical insight but rather an impoverishment of our conceptual toolbox. The struggle against capitalism is different from the struggle against patriarchy and racism, even if the ultimate aim should be the removal of all structures of oppression and domination.
Monitoring Iklim Mikro pada Greenhouse Secara Real Time Menggunakan Internet of Things (IoT) Berbasis Thingspeak
Authors: Kurniawan Anri , Ristiono Andika , Sulistiadi Slamet
Published: January 2022

Farm cultivation in the highlands is constrained by the long rainy season, less efficient sunlight and susceptible to pests and diseases. One of the solutions in cayenne pepper cultivation is using hydroponics and greenhouse s to minimize pests and diseases that come from the soil and are carried by the wind. The purpose of this research is to produce "SMART-IGHIOT" a control system based on the Internet of Things using Dutch bucket hydroponics in a portable greenhouse. The technology applied is in the form of monitoring and controlling temperature, humidity, air temperature and light intensity using sensors integrated with the ESP32 microcontroller. The ESP32 is connected to the Thingspeak webserver to display sensor measurement results in real-time. The design of the monitoring system for light intensity, temperature and humidity in the greenhouse can be maximized so that environmental conditions can be optimized. The performance of using greenhouse s can maximize the intensity of sunlight, the highest at 12.00, while the lowest temperature at 03.00 to 05.00 WIB. While the highest temperature is at 13.00 and the highest humidity is at night. Keywords: dutch bucket, greenhouse, IoT, microclimate, Thingspeak
Penerapan Analisis Runtun Waktu pada Peramalan Penjualan Produk Organik menggunakan Metode Moving Average dan Exponential Smoothing
Authors: Ardiansah Irfan , Adiarsa Irsyad Fauzi , Putri Selly Harnesa , Pujianto Totok
Published: January 2022

The purpose of this study is to answer the problem of procurement of goods and minimize goods reaching expiration due to too long storage time, then as a provider of information about the forecasting system at Warung Sehat 1000 Kebun, then to predict sales of goods at Warung Sehat 1000 Kebun and identify how many goods that have been sold. This research uses a quantitative approach. The data used in this study is sales data for 2 (two) months with 30 lines of data and a total of 3 types of goods studied, namely sales data of pakcoy, cocofresh and free-range chicken eggs. The method used starts from data collection, forecasting calculations, forecasting testing, forecasting selection, and forecasting application. The forecasting methods used are moving average and exponential smoothing, by testing the mean absolute deviation, mean square error, and standard deviation. Forecasting results yielded outputs for pakcoy products as much as 1583.33 grams, for cocofresh products as many as 11 pcs and for chicken eggs as many as 9 pcs. Keywords:  exponential smoothing, forecasting examination, time series data, moving average
STRATEGI MENINGKATKAN KEPATUHAN PAJAK REKLAME DENGAN PENDEKATAN COMPLIANCE MODEL
Authors: Wijayanah Wijayanah , Basuki Basuki
Published: January 2022

This study aims to describe the implementation of compliance strategies in revenue agencies using the compliance model approach to improve advertising tax compliance. The research data were collected by interview, observation and document collection. This research is a descriptive qualitative research with a case study approach. Data analysis was performed using qualitative techniques, consisted of 3 stages, namely data reduction, data display, and conclusion drawing. The results of the study provide empirical evidence that compliance strategy with a compliance model approach that is implemented comprehensively and adequately can increase taxpayer compliance. The strategy implemented includes providing ease of compliance, providing assistance to comply, taking deter by detection and use full force of the law. Its combines effective prevention strategies and credible enforcement, making easier for taxpayers who are committed to comply and take firm action against taxpayers who do not comply. Implementation of compliance strategy requires support of facilities and infrastructure, competent human resources, tax authorities commitment, laws and regulations as a basis for implementation and support from other agencies in law enforcement efforts. The results of this study can become a reference for policy makers in developing future compliance strategies to achieve voluntary compliance in a sustainable manner.
Editorial
Authors: Fernández-Arata Manuel
Published: January 2022

Nos complace compartir con la comunidad académica nacional e internacional el segundo número del volumen 27 de Liberabit, Revista Peruana de Psicología. Este número está constituido por seis artículos, los cuales pasamos a describir brevemente.
Iniciamos esta presentación con el trabajo realizado por David Pascual Olivo Chang, Cecilia Chau Pérez-Aranibar, Fiorella Otiniano Campos y Silvana Melissa Romero Saletti, en donde reportan que la adaptación de la subescala de marihuana de la escala de Autoeficacia para el rechazo del Consumo de Drogas (DURSE) en adolescentes peruanos tiene propiedades adecuadas de validez interna ajustada a la estructura interna, así como una alta confiabilidad para medir la autoeficacia para el rechazo de consumo de marihuana en futuras investigaciones; con respecto al sexo, se encontró invarianza escalar pero no métrica. Asimismo, quienes no habían consumido marihuana, no tenían intención de probar o habían rechazado la oferta de consumo, obtuvieron mayores niveles de autoeficacia. En segundo lugar, el reporte de Ricardo Galguera Rosales, Alejandra Pedraza Herrera, Alberto de la Rosa Herrera, Edgard Rocha Hernández y Héctor Octavio Silva Victoria evalúa el efecto de distintas distribuciones del perjuicio y la cantidad de este sobre la elección entre perjudicar o no al otro en estudiantes universitarios mexicanos. Al respecto, encontraron que hay un efecto diferencial entre las distribuciones y una tendencia a la reciprocidad entre el perjuicio recibido y el perjuicio cometido cuando el perjuicio es proporcional a la cantidad de este; cuando la conducta perniciosa emerge, hay una identificación de quién perjudica, el puntaje, el momento y el sujeto del perjuicio.
ICT platforms for Indonesian EFL students viewed from gender during the COVID-19 pandemic
Authors: Apriani Eka , Arsyad Safnil , Syafryadin Syafryadin , Supardan Dadan , Gusmuliana Paidi , Santiana Santiana
Published: January 2022

The aims of this study are to find out (1) ICT (Information and Communications Technology) platform used by male and female students from Islamic universities in Indonesia, (2) their perception of using ICT, and (3) their barriers to using ICT in English language learning during the COVID-19 pandemic. The data was collected from an online questionnaire (Google Form) from students majoring in English from seven Islamic universities in Indonesia. There were 30 male students and 30 female students from every university who participated in this research, making a total of 210 student respondents. The data were analyzed quantitatively by using the SPSS computer program. First of all, female students used more various types of ICT platforms compared to male students. Second, the female students viewed ICT use more positively than male students in language learning. And lastly, even though the females deemed ICT more optimistically compared to male students, nevertheless the females encountered more barriers in using the ICT platforms compared to the male students in this study. Again, even though male students were more skillful in ICT literacy than female students, female students constructively regarded ICT use in language learning as more beneficial to them in terms of skill, knowledge, and motivational improvement.
Print-based multimodal texts: Using illustrated poems for generating ideas and writing narratives
Authors: Rajendra Thusha Devi , Kaur Surinderpal
Published: January 2022

The article provides insights on how print-based multimodal texts can be utilized to generate ideas and help students to write narrative texts. A qualitative approach in research design was employed with a pre-test and a writing assignment. NAPLAN’s (2010) Writing-Narrative Marking Guide was adapted to evaluate the respondents’ narrative essays. Moreover, diary notes were used as instruments to gather data. The respondents were five Year 10 students from a suburban secondary school in Selangor, Malaysia. The findings indicated that the illustrated poem ‘Pond’ enabled the respondents to generate ideas for their writing. The narratives also fulfilled the criteria of text structure, ideas, character and setting, and vocabulary as stated in the Analytical Rubric for Narrative Marking. Therefore, the respondents were able to write narratives. However, the utilisation of picture stimulus only helped to generate ideas to a certain extent. The quality of narrative writing was also further improved through feedback provided during the teaching and learning sessions. The findings also revealed that the respondents were able to achieve the ‘can do’ statement as stated in the CEFR Assessment Format. Furthermore, the use of print-based multimodal texts encouraged multimodal and visual literacy as the respondents exploited semiotic resources within the texts. This study suggested that print-based multimodal texts could be used as instructional materials in narrative writing; thus, teachers should consider them to promote effective learning.
Revisiting integrative motivation: Validation of International Posture among Malaysian undergraduates
Authors: Razak Fatin Nabila Abd , Nimehchisalem Vahid , Tan Helen , Lee Geok Imm , Abdullah Ain Nadzimah
Published: January 2022

Gardner’s (1985) in his socio-educational model introduced the variable of ‘integrativeness’ as a construct that focuses on English as a Second Language (ESL) learners’ attitudes towards the native English community. Later, Yashima (2002) proposed ‘international posture’ as an affective construct that re-examined ‘integrativeness’. Research conducted to reach a common operationalisation of ‘international posture’ is very limited. Hence, our objective in this study is to determine the level of each measurement construct under the affective variable of International Posture as well as to validate the measurement constructs of this variable among Malaysian undergraduates. In this quantitative study, 540 undergraduate students from a public university were selected. These students responded to a questionnaire that contained the four measurement constructs. For analysing the data, we used Partial Least Square-Structural Equation Modelling (PLS-SEM). Our results have proven that the International Posture among Malaysian undergraduates is high, and the measurement constructs of this variable are valid and can be operationalised in the Malaysian English language learning context. The scale validated in the study can contribute to future studies on this variable in the Malaysian English language learning context.
Baśń czy nie baśń? O polskim definiowaniu fantasy w siedmiu aktach
Authors: Kaczor Katarzyna
Published: January 2022

Przedmiotem tekstu jest przedstawienie polskiego dyskursu definicyjnego fantasy jako konwencji literatury fantastycznej – od momentu jej zaistnienia za pośrednictwem przekładu Tolkienowskiego Władcy Pierścieni w latach 1961–1961 i pierwszych prób jej zdefiniowania do momentu ukształtowania się zjawiska i przejęcia jej dyskursu definicyjnego przez polskich autorów fantasy w latach dziewięćdziesiątych XX wieku. Dobór wypowiedzi znaczących i ich interpretacja zostały dokonane w odniesieniu do teorii dyskursu Michela Foucaulta i teorii pola Pierre’a Bourdieu.
Andrzeja Sapkowskiego i Jacka Dukaja rozważania o fantastyce
Authors: Pindel Tomasz
Published: January 2022

Artykuł zawiera analizę wypowiedzi teoretycznoliterackich dwóch ważnych polskich pisa­rzy fantastyki – Andrzeja Sapkowskiego i Jacka Dukaja. Choć są to wypowiedzi rozproszone i utrzymane w publicystycznym tonie, podejmowane są w nich ważne tematy dotyczące fan­tasy i SF, ich cech gatunkowych oraz relacji z innymi typami literatury.
Design and Fabrication of Nanostructure TiO2 Doped NiO as A Gas Sensor for NO2 Detection
Authors: Al-Taa'y Wasan A. , Hasan Bushra A.
Published: January 2022

In this paper, thin films of undoped and nickel oxide (NiO) doped titanium dioxide (TiO2) were prepared using the chemical spray pyrolysis deposition (CSP) technique, with different concentrations of nickel oxide (NiO) in the range (3-9) wt%. The morphological, structural, electrical, and sensing properties of a gas of the prepared thin films were examined. XRD measurements showed that TiO2 films have a polycrystalline structure. AFM analysis showed that these films have a regular structure both before and after doping . The roughness of these films  decreased after adding  impurities but then the opposite of that took  place. The electrical and gas sensing properties of titanium dioxide  was also affected after doping. The highest sensitivity value was obtained at doping concentration of 5wt% and working temperature 473ºK.
La innovación y sus implicaciones en las empresas del sector metalmecánico en la ciudad de Cartagena: caso Asimecar
Authors: Cottiz Montoya Nelson Eduardo
Published: January 2022

En este trabajo se analiza la capacidad de innovación de las empresas metalmecánicas de la ciudad de Cartagena (Asimecar) entre los años 2010 y 2011. Para esto, se evalúan los factores: tipos de innovación, beneficios de las innovaciones, fuentes de innovación y dificultades presentadas al momento de la implementación de la innovación. La muestra objeto de estudio estuvo constituida por todas las empresas que conforman la asociación (en total son ocho empresas). Esta investigación es de tipo descriptivo, cuantitativo, de datos primarios y los resultados muestran que las empresas metalmecánicas implementaron innovaciones organizacionales y de procesos, las cuales mejoraron la calidad de los productos, redujeron costos, entre otros aspectos. La principal fuente de innovación fueron los clientes y las principales dificultades al momento de innovar fueron la falta de recursos económicos y la falta de preparación de los empleados.
The Relationship Between The Level Of Parental Knowledge About Covid-19 And The Application Of Clean And Healthy Living Behavior In Early Childhood During The Pandemic
Authors: Faizal Afrah Diba , Suryanis Ira , Satria Epi
Published: January 2022

The increasing number of Covid-19 cases in children in Indonesia has caused  parents to make more efforts to protect their children. Parents' knowledge is the domain in the formation of Covid-19 prevention behavior by implementing clean and healthy living behaviors in children. This study aims to determine the relationship between the level of parental knowledge about Covid-19 and the application of clean and healthy living habits in early childhood during the pandemic. This research is an analytic observational study with a cross sectional approach. The population in this study were 35 parents of PAUD Nurul Quran. The frequency distribution of the level of knowledge about Covid-19, the majority of respondents have a good level of knowledge about Covid-1, namely 25 respondents or 89.3% and the frequency of implementing clean and healthy living habits in early childhood during the pandemic, it is known that most respondents 20 respondents or 71.4% have implemented a clean and healthy lifestyle. Based on the results of research with the Spearman rho test, it is known that the Asymp. Sig. (2-sided) of 0.001 <α (0.05) with a correlation value of 0.333, this means that there is a relationship between the level of parental knowledge about Covid-19 and the application of clean and healthy living habits in early childhood during the pandemic in a positive direction. and the closeness of the relationship is moderate.
The Effectiveness of the Use of the Dysmenorrhea e-booklet on Increasing Knowledge of SMAN 28 Tangerang Students in the Covid-19 Era
Authors: Wardani Dyah Woro Kartiko Kusumo , Dewi Ni Nyoman Sri Artina , Suhaid Dewi Novitasari
Published: January 2022

Dysmenorrhea is a condition where pain occurs before, during and after menstruation. The most common cause of dysmenorrhea is hormonal factors. The incidence of dysmenorrhea worldwide is quite high, and Indonesian adolescents experiencing dysmenorrhea reach 43%-93%. The impact of dysmenorrhea on adolescents is the disruption of activities and a decrease in academic achievement due to lack of concentration and frequent absence of students from school. Lack of knowledge related to dysmenorrhea makes adolescents less precise in carrying out treatment; it can be seen from the number of adolescents who take anti-pain drugs to reduce dysmenorrhea pain which can cause side effects. Treatment of dysmenorrhea in addition to pharmacological can use non-pharmacological treatment.The purpose of this study was to see the effect of using dysmenorrhea e-booklets on increasing knowledge of SMAN 28 Tangerang students in the Covid-19 Pandemic Era.This pre-experiment research using a questionnaire. The research design used a One Group Design Pretest-Postest research design. The research sample was all 10th grade students of SMAN 28 Tangerang. Sampling technique was carried out using accidental sampling. The effectiveness of the dysmenorrhea e-booklet in increasing the knowledge of SMAN 28 Tangerang students was analyzed using the Wilcoxon test and obtained a significance value (sig) of 0.000 (p<0.05). The p value <0.05 indicated a significant difference between the score before being given the e-booklet and the score after given the e-booklet. Therefore, it can be concluded that the provision of dysmenorrhea e-booklets is effective in increasing respondents' knowledge about dysmenorrhea in the Covid-19 era.
The Feminization of the Intergenerational Transmission of Knowledge About Witchcraft and Healing Among Don Cossacks in the First Half of the Twentieth Century
Authors: Власкина Татьяна Юрьевна
Published: January 2022

В статье рассматриваются инверсии традиционной передачи сакрального знания у донских казаков в сфере целительства и колдовства. Предмет изучения - практики профессиональной и репродуктивной магии, для которых ранее было особенно характерно подчеркнутое противопоставление мужского и женского начала. Названное явление обусловлено общероссийским социальным контекстом первой половины XX в. - сломом сословной системы, советской модернизацией общества. На территории Области войска Донского ситуацию усугубили фактическая маргинализация казачества, составлявшего до 1914 г. большую часть населения, и убыль взрослых мужчин, в результате чего феминизация охватила многие стороны повседневной жизни и традиционной культуры. Источником исследования являются полевые материалы 1997-2008 гг., зафиксированные на территории нескольких районов Ростовской и Волгоградской областей.

This article examines the changes in the traditional transmission of sacred knowledge among the Don Cossacks in the areas of healing and witchcraft. It involves the practice of professional and reproductive magic, for which the sharp opposition of masculine and feminine principles was previously characteristic. The causes of this phenomenon lie in the Russian social context of the first half of the twentieth century, namely the destruction of the estate system and the Soviet modernization of society. In the Don Cossack Region, the situation was aggravated by the marginalization of the Cossacks and the decline of the male population, as a result of which feminization embraced many aspects of everyday life and traditional culture. The research is based on field data from 1998-2008 recorded in several districts of the Rostov and Volgograd regions.
An infectious virus-like particle built on a programmable icosahedral DNA framework
Authors: Yang Yang , Xu Yunyun , Yang Yuhe , Shi Qian , Ward Andrew , Wang Wei
Published: January 2022

Viral genomes can be compressed into a near spherical nanochamber to form infected particles. In order to mimic the virus morphology and packaging behavior, we invented a programmable icosahedral DNA nanoframe with enhanced rigidity and encapsulated the phiX174 bacteriophage genome. The packaging efficiency could be modulated through specific anchoring strands adjustment, and the enveloped phage genome remained accessible for enzymatic operations. Moreover, the packed complex could infect E. coli cells through bacterial uptake then produce plaques. This rigid icosahedral DNA architecture established a versatile platform to develop virus mimetic particles for convenient nucleic acid entrapment, manipulation and delivery.