bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Edukasi Pemberian Tablet Tambah Darah Terhadap Pengetahuan Remaja Putri Tentang Pencegahan Anemia Saat Menstruasi
Authors: Ningsih Widya Astrea , Ernawati
Published: February 2025

Latar Belakang: World Health Organization (WHO) menyebut masa remaja sebagai fase peralihan dari anak-anak ke masa dewasa, yang terjadi antara usia 10-19 tahun. Tujuan dari upaya kesehatan remaja adalah untuk mempersiapkan remaja untuk menjadi orang dewasa yang sehat, cerdas, berkualitas, dan produktif, serta berpartisipasi dalam menjaga, mempertahankan, dan meningkatkan kesehatan diri mereka sendiri. Tujuan Penelitian: Tujuan dari penelitian ini adalah untuk mengetahui dan mengidentifikasi  pengaruh pengaruh edukasi pemberian tablet tambah darah terhadap pengetahuan remaja putri tentang tablet tambah darah dalam upaya pencegahan anemia sebelum dan setelah diberikan pendidikan kesehatan. Metode: Metode yang digunakan dalam penelitian ini adalah kuantitatif, yang berlandaskan pada filsafat positivisme untuk meneliti populasi tertentu. Pengambilan sampel dilakukan secara acak dan pengumpulan data menggunakan instrumen yang sesuai, serta analisis data dilakukan secara statistik. Hasil: pengetahuan remaja sebelum diberikan edukasi kesehatan yaitu dari total 86 remaja yang diuji, 21 (24,4%) remaja memiliki tingkat pengetahuan yang baik. Setelah diberikan edukasi kesehatan yaitu dari total 86 remaja yang diuji, 60 (69,8%) remaja memiliki tingkat pengetahuan yang baik. Sedangkan p-value diperoleh adalah 0,000. Nilai ini menujukkan bahwa terdapat perbedaan signifikan antaran pre-test dan post-test. Kesimpulan: Hasil penelitian ini membuktikan adanya pengaruh yang signifikan terhadap pengetahuan remaja setelah diberikan penyuluhan pengetahuan remaja putri tentang tablet tambah darah p-Value < 0.000.
Assessment of utilization of wild edible plants and their contribution to the livelihoods of rural communities; case study: Koro sub-county, Omoro district
Authors:   ,   Uganda Martyrs University, Aijuka Joshua
Published: February 2025

Wild edible plants are important food supplements which reduce vulnerability to food insecurity especially in times of food shortage in Uganda. However, limited information is available on knowledge and their use in Uganda. Therefore, this study was conducted to identify different Wild Edible Plants (WEP) and their benefits; assess the knowledge level of the community on the importance of Wild Edible Plants (WEP) to their livelihoods and determine the available strategies for sustainable utilization and conservation of Wild Edible Plants (WEP) to the rural communities of Koro S/C; Omoro district. A series of participatory tools (key informant interviews, observation) was followed by a household survey (150 respondents) from three (3) randomly selected parishes namely; Labwoch, Ibakara and Pageya. According to the findings, a total of 21 Wild Edible Plants (WEPs) species with high diversity and multiple use values were documented in Koro S/C. WEPs species such as Ximenia Americana L., Chlorophytum comosum, Amaranthus spinosus L., Aframomum angustifolium (Sonn.) K.Schum, Vitellaria paradoxa C.F. Gaertn, and “Oyado.” were highly utilized due to their multitude of benefits. Peoples in Koro S/C perceived WEPs to be of food and nutritional value, medicinal value, and economic value. The decline of WEPs availability and utilization was due to environmental degradation, rapid urbanization and overexploitation. Some of the strategies for sustainable utilization and conservation of WEPs in the area were; community sensitization, domestication of wild edible plants, local regulations on management of the Wild edible plants, promotion of sustainable alternatives for harvesting and utilization of WEPs, and market-led initiatives through value addition and value chain development. However, the study further established that although there were some notable strategies for sustainable utilization and conservation of WEPs in the area, these were not very effective due to the limited resources affecting outreach of the interventions, limited awareness on the available bi-laws and regulations, and limited involvement of communities in the design and implementation of the interventions. It was recommended that the government and civil societies intensify community sensitization on the importance of sustainable utilization and conservation of the wild edible plants for posterity. Sustainable business models need to be developed to facilitate increased and equitable economic benefits along the value chain as a mechanism for incentivizing sustainable management of WEPs and their sources. Finally, the community members need to engage in wild edible plants domestication and conservation of WEP sources for continued utilization of wild edible plants for their enormous benefits to food, nutritional, medicinal and economic values.
Exploring Various Flavors of Cilok Snacks for Profit: A Small and Medium Enterprises Activity by Students of Indo Global Mandiri University in Support of MBKM
Authors: Hidayahtullah Hafiz , Hertati Lesi , Asharie Asmawati , Avini Terti
Published: February 2025

The MSME activity carried out by Indo Global Mandiri University students, entitled "Exploring Eneka Rasa Cilok Snacks," is a creative initiative that supports the Student Based Internship Program (MBKM). This activity aims to generate profits through variations in taste in making cilok snacks, which are not only a unique culinary product but also make a positive contribution to the student economy. In developing cilok snacks, students are actively involved in various aspects of the business, including production planning, stock management, marketing, and interaction with local traders to obtain raw materials. Apart from creating additional income opportunities for students, this activity also supports the empowerment of local MSMEs and the preservation of traditional culinary delights. Involvement in MBKM activities provides students with in-depth practical experience in managing small and medium enterprises. Exploration of cilok snacks not only creates a positive economic impact, but also promotes innovation, creativity and understanding of the importance of local economic empowerment. Through this initiative, students not only develop their entrepreneurial skills but also contribute to the formation of community networks around campus. Thus, "Exploring Cilok Eneka Rasa Snacks" is a real example of how student MSME activities can be agents of positive change in supporting local economic growth and providing rich practical experience for participants
Performance Analysis on Road Implementation Project Based on Time and Cost
Authors: Alves Agata Maria Orleans , Tjendani Hanie Teki , Wulandari Esti
Published: February 2025

Effective time management is essential for ensuring project implementation aligns with the planned schedule, and one way to achieve this is through the use of Earned Value Analysis (EVA). EVA is employed to estimate the extent to which a project is progressing according to its work plan. This research aims to analyze the timeline of a road construction project using the Earned Value Analysis Method to estimate the final project completion time on a monthly basis. The methodology employed in this study involves the application of the Earned Value Method over a project duration of 18 months. The importance of the Earned Value Analysis Method lies in its ability to assist both the project owner and implementer in more easily analyzing the project's performance, thereby providing significant benefits for both parties. The study found that the project completion time did not align with the initial project schedule. Specifically, the calculation of the cumulative project completion time was 9 months, whereas the planned duration was 18 months. This indicates a delay of 7 months beyond the planned schedule.
Investment Sensitivity Analysis of Transjatim Corridor I Luxury Sidoarjo-Surabaya-Gresik Route
Authors: Novalia Kiki Devita , Muhammadun Haris , Marleno Risma
Published: February 2025

Based on the recapitulation of Transjatim Corridor I passengers in 2023, the average load factor is 120%, with an average of 5-6 thousand passengers per day, leading to the addition of a fleet with luxury services. This study aims to analyze the financial feasibility of investment in the Transjatim Luxury Bus Corridor I by comparing income and expenditure variables using the Net Present Value (NPV), Benefit-Cost Ratio (BCR), Internal Rate of Return (IRR), and Payback Period (PP) methods. With a 6% discount rate, the analysis yielded NPV values > 0 (Rp. 5,204,972,631 for alternative 1, Rp. 2,466,479,592 for alternative 2, and Rp. 640,817,566 for alternative 3), IRR values > 6% (19.42% for alternative 1, 12.54% for alternative 2, and 7.74% for alternative 3), and BCR values > 1 (1.30 for alternative 1, 1.19 for alternative 2, and 1.11 for alternative 3). The PP values were 4 years for alternative 1, 5 years for alternative 2, and 6 years for alternative 3, indicating that all three alternatives are financially feasible. Sensitivity analysis confirmed the financial feasibility of all three alternatives, considering the effect of the discount rate on NPV.
Training on Social Media Marketing Strategies to Increase Competitiveness in SMEs
Authors: Rasyid Ardiansyah , Clarissa Clarissa , Chandra Fredicko Decastro , Dharmawan Jones Guna
Published: February 2025

Social Media Marketing is a marketing activity using social media sites such as Facebook, Twitter, Youtube, and so on. The activity partner is located in Jakarta. In its activities, it is known that partners have difficulties in the field of social media marketing. The activity aims to provide solutions to partners in improving their ability to compete and consistency in posting content. The activity method is carried out by conducting training on social media marketing, namely by presenting information and knowledge in determining social media marketing strategies. The advantages of this strategy are that the costs incurred are not too large, have broad access, besides that the operation is also quite easy. Training is conducted directly to the partner's place. With activities carried out by making PPT containing information that can be utilized to increase competitiveness using social media marketing has run smoothly. The output of activities in the form of publications to journals and IPR.
Profitability Analysis in Improving Business Success
Authors: Rasyid Ardiansyah , Setiawan Levina , Mardjo Johanna Aurielle
Published: February 2025

The rapid increase in the economy makes competition between companies to maintain its sustainability increasingly intense. How a company manages its working capital can affect the level of profitability of the company. PKM programmes are conducted to introduce the partners to profitability by managing the business partners' working capital. The training method uses zoom meetings and is assisted by two students. The material is presented in the form of PPT which includes: understanding profitability, managing receivables, payables, and inventory. The results of the activity show that training on profitability analysis has been carried out online and runs smoothly. The partner received the information and materials presented with enthusiasm, and asked questions during the activity process.
Sensitivity Analysis of Revenue Potential in The Evaluation of East Surabaya Hospital Investment
Authors: Astasari Arianti Widi , Oetomo Wateno , Sajiyo Sajiyo
Published: February 2025

As one of the largest cities in Indonesia, the City of Surabaya has an obligation to provide excellent health services for its residents. It goes without saying that Surabaya City Government is required to provide a General Hospital that can receive referrals from the government-owned Community Health Centers. For this reason, the Surabaya City Government built the East Surabaya Hospital which is located in Rungkut Sub-District. East Surabaya Hospital is a strategic project that requires investment feasibility analysis. The East Surabaya Hospital investment feasibility analysis was done by applying the Net Present Value (NPV), Internal Rate of Return (IRR), Payback Period (PP) and Benefit Cost Ratio (BCR) parameters. After the feasibility analysis results were obtained, a sensitivity analysis was done on changes in management costs and the amount of health service levy rates for each Fees alternative. Based on the results of the investment feasibility analysis of 4 (four) Fees alternatives, there are 2 alternatives that can be concluded as worthy investments, which are alternative 1 and alternative 3. Meanwhile, alternative 2 and alternative 4 are not feasible since the NPV parameter shows negative values and the IRR value is lower than the MARR value. However, based on sensitivity analysis, alternatives 2 and 4 can be feasible if alternative 2’s service rate is increased by 13.2%, and alternative 4’s service rate is increased by 2.3%. The opposite applies in alternative 1 where the investment might become unfeasible if the service rate is reduced by more than 5.4% and alternative 3 might become unfeasible if the service rate is reduced by more than 2.5%.
Understanding the Consumer Market in Improving the Buyer Behavior of Hong Kong Buns
Authors: Rodhiah Rodhiah , Chandra Dominikus Rinaldo , Nataputra Rafael Pascal , Ray Christian
Published: February 2025

Every day, consumers are faced with numerous choices about what to purchase, and these choices are the main focus of marketing strategies. Major corporations invest heavily in researching consumer buying habits to gain insight into what, where, how much, and why consumers make purchases. While marketers can seek to understand consumer behavior, it is a challenging task. Oftentimes, consumers are unaware of the factors that drive their purchasing decisions. The partner or training site is a Hong Kong Buns culinary business located in Surabaya City. In its operations, it faces many obstacles, especially in terms of understanding consumer behavior in an effort to increase purchases. Meanwhile, this activity aims to help partner businesses understand these obstacles. The activity method is carried out by online training. Through this activity, it is hoped that the problems that arise in the company can be resolved, so as to increase sustainability in marketing the services sold accompanied by knowing more about the consumer market and buyer behavior. The output of this activity is in the form of publications to journals and IPR.
Framing Analysis of Street Race Ancol News on Metro TV
Authors: Ramadhan Tubagus Ryan , Maulianza Medo
Published: February 2025

This research is motivated by the inaugural Street Race event initiated by the Metro Jaya Police Chief in early 2022, during which various news programs on Metro TV made several special broadcasts about the Street Race implementation process related to the Metro Jaya Police's efforts to overcome the problem of illegal racing that often occurs in big cities. This research aims to understand why Metro TV is framing the issue of Street Race implemented by Polda Metro Jaya and then associated with Robert N. Entman's framing analysis and how the program constructs it. The literature review in this research includes Mass Communication, Mass Media, Television News, Framing Analysis, Framing Theory According to Robert Entman, and Framing Tools. This research applies a descriptive analysis approach. The descriptive method is used to explore or investigate the events under study. This research describes how framing is formed in news programs, focusing on two dimensions, namely issue selection and emphasis on certain aspects of the issue. The results of the research show the prominence of framing in the reality of the construction of the news of the Inaugural Street Race in Ancol, that the street race event, which was initiated by the Metro Jaya Police Chief, received support and appreciation from various parties, ranging from the Chairman of the Indonesian Motor Association (IMI), Motorsport Observers to the Motorcycle Community. Through the use of this positive framing framework, it succeeded in constructing a narrative that supported police actions in overcoming the illegal races that often happen.
Working Capital Management in Efforts to Improve Profitability and Competitiveness of MSMEs
Authors: Yusbardini Yusbardini
Published: February 2025

Effective and efficient working capital management is necessary for every MSME so that the company's operational activities can increase profitability and competitiveness. Good working management can enable MSMEs to manage inventory, improve product marketing, and respond quickly to market changes, thereby increasing the competitiveness and profitability of MSMEs. The purpose of this service is to provide counselling on working capital management to Vezara MSMEs in PGC Cililtan East Jakarata. This training aims to make Vezara MSMEs understand working capital management so that cash can be used as efficiently as possible, selling goods as quickly as possible, avoiding liquidity problems and increasing production capacity. MSME owners must really know effective and efficient working capital management because this is the key to successful MSME operational activities in producing profitability and competitiveness. Therefore, the PKM Team needs to provide this training to help Vezara MSMEs make a profit.
The Level of People's Salt Business Empowerment (PUGAR) Reviewed From Market Demand
Authors: Sadiqin Amin , Sunarti Sunarti
Published: February 2025

The implementation of the People's Salt Business Empowerment Program (PUGAR (Pemberdayaan Usaha Garam Rakyat)) to intensify salt fields and boost people's salt productivity is considered slow. The PUGAR needs to be revitalized to enhance the welfare of salt farmers and achieve industrial salt self-sufficiency by 2015. The aim of this research is to analyze the empowerment of people's salt businesses (PUGAR) based on the aspects of Central Java's industrial salt demand, with a focus on determining the level of empowerment of salt businesses in the Central Java region. The research was conducted by distributing questionnaires to salt farmers and utilizing existing data. The results indicated low market demand but high social and cultural aspects and business sustainability. Short-term priority actions include optimizing applied technology for the production process, improving the distribution chain, and ensuring sustainable market information to stabilize the people's salt business.
The Influence of Human Resource Development, Job Satisfaction on Employee Performance at PVH Venlo, The Netherlands
Authors: Thenu Agners Rosario , Hidayat Rahmat
Published: February 2025

This research aims to analyze the influence of human resource development (HR) and job satisfaction on employee performance at PVH Venlo, the Netherlands. The research method used was a questionnaire survey distributed to 90 PVH Venlo employees. The data was then analyzed using structural equation modeling with partial least squares. SEM was chosen because it is more accurate in processing data, not only to obtain causality between variables and constructs but also to determine the magnitude of the relationship between variables and constructs. The research results show that HR development has a positive and significant influence on employee performance. Apart from that, job satisfaction was also found to have a significant influence on employee performance. The combination of an effective HR development program and a high level of job satisfaction contributes significantly to improving employee performance at PVH Venlo. These findings underscore the importance of investing in human resource development and increasing job satisfaction as key strategies for improving organizational performance. This research provides practical implications for PVH Venlo management to continue optimizing HR development programs and creating a work environment that supports employee satisfaction.
The Influence of Service Quality and Trust on Customer Satisfaction
Authors: Solikha Fitriatus , Zunaida Daris , Eny Eny
Published: February 2025

The primary objective of this research is to identify and examine how service quality impacts customer satisfaction. To understand and analyze the relationship between trust and customer satisfaction. To explore and analyze the simultaneous and partial impact of service quality and customer satisfaction guarantees. A quantitative research approach was applied in this kind of research. The recorded review approach used a sample of 115 participants. According to the evaluation findings, customer satisfaction is positively and significantly influenced by service quality (X1), as evidenced by a t-calculated score greater than the t-table score (4.196 > 1.981) and a significance level below 0.05 (0.000 < 0.05). Additionally, customer satisfaction regarding the F-test value is influenced by both service quality and trust, determined by an F-table score greater than the F-calculated score (165.263 > 3.08) and a significance level of F below 0.05 (0.000 < 0.05). The adjusted R-square score of 0.742, also known as the coefficient of determination (R2), indicates that the total contribution of all X variables, namely trust and service quality, to the Y variable, which is customer satisfaction, is 74.2%. The remaining 25.8% is attributed to other factors not covered in this research.
The Impact of Disclosures on Green Accounting, Corporate Social Responsibility, and Corporate Governance on Stock Returns
Authors: Safitri Yasmin , PurwohediMurwanigsari Unggul , Yusuf Muhammad
Published: February 2025

This research investigates the impact of disclosing sustainability reports, encompassing Environmental, Social, and Governance (ESG) aspects, on stock returns. Environmental factors are represented by green accounting, social by corporate social responsibility, and governance by corporate governance. The study employs quantitative methods using secondary data from sustainability reports of companies listed on the ESG Leaders index from 2017 to 2022 (total of 138 samples). Descriptive statistical analysis of panel data using Eviews 12 software was conducted. Results indicate that while green accounting does not significantly influence stock returns, both corporate social responsibility and corporate governance have a positive impact. This study suggests that companies can enhance their ESG reporting to cultivate a positive stakeholder image and potentially increase stock returns.
Analysis of Pension Fund Payment Data Processing Information System Design
Authors: Antari Primadela , Bufra Fanny Septiani , Andesti Cyntia Lasmi
Published: February 2025

Research has been carried out at PT. Pos Indonesia (Persero) Lubuk Sikaping, and problems were found regarding the processing of pension fund payment data, where data processing was still manual and data storage still used folders and stored in filing cabinets. The report creation process is long and inefficient. In writing this research using the SDLC development method (System Development life Cycle) using the Visual Basic 6.0 programming language. In the results of this research, the design analysis used is the Information System Flow. The results of this research are a new system that has the advantage of minimizing the risk of errors or errors error which occurs in processing pension fund payment data as well as assisting in preparing reports and archiving data. It is hoped that PT Pos Indonesia (Persero) Lubuk Sikaping can apply and use this new system and can overcome problems in processing data on pension fund payments.
The Influence of Corporate Governance, Intellectual Capital and Corporate Social Responsibility on The Financial Performance of Pharmaceutical Companies on The Indonesia Stock Exchange
Authors: Suaidah Yuniep Mujati
Published: February 2025

This study aims to test and prove the effect of corporate governance, intellectual capital, and Corporate Social Responsibility on the financial performance of the pharmaceutical sector. This research is descriptive and quantitative. Secondary data sources were used with documentation data collection techniques. The sampling technique was purposive sampling, with criteria including pharmaceutical sector companies that published complete financial reports from 2010 to 2023, resulting in a sample of 135 financial reports. The results indicate that corporate governance does not affect financial performance, implying that pharmaceutical companies are less able to build governance to improve financial performance. Intellectual capital affects financial performance, indicating that pharmaceutical sector companies can utilize resources to improve financial performance. Corporate Social Responsibility affects financial performance, meaning that the responsibilities carried out by companies in terms of economic, social, and environmental aspects can improve financial performance.
The Influence of BTS as Tokopedia Brand Ambassador on Customer Loyalty
Authors: Nabilla Zulfa , Prasetyawati Happy
Published: February 2025

In this modern era, the use of the internet seems to be human daily food. There is no day without opening the internet, starting from news, information, entertainment and even shopping can be accessed via the internet. Tokopedia is an e-commerce that is quite influential in Indonesia today, this cannot be separated from a marketing communication strategy which is a tool to influence others, provide information and spread the promotion in marketing activities so that success occurs within the company. Tokopedia made Bangtan Sonyeondan or BTS, commonly known as its brand ambassador, as a marketing communication strategy in improving the brand image and loyalty of Tokopedia customers. The current study aims to determine the effect of BTS as a Brand Ambassador at Tokopedia on customer loyalty. The theory used in this research is Uses And Gratification theory. The results of the study show that BTS as Tokopedia's Brand Ambassador has a positive and significant influence on Customer Loyalty.
The Influence of Work Discipline and Work Motivation on Employee Work Productivity (Study at UD. Primacon Paving)
Authors: Prasetiyo Dimas Eka , Prasetyo Deni Widyo
Published: February 2025

The main objective of this study is to examine how work discipline and motivation affect the work productivity of production employees at UD. Primacon Paving. An explanatory research approach is employed, involving field data collection.   The target population consists of 47 employees working in the production department at UD. Primacon Paving Kepuh Kembeng. The researchers utilised multiple Linear Regression statistical methods and hypothesis testing to analyse the data, as well as the coefficient of determination.   The study findings suggest that maintaining good work discipline can positively influence the work productivity of employees at UD. Primacon Paving Kembeng, while high levels of work motivation can lead to increased Employee Work Productivity at UD. Primacon Paving Kembeng.
Analysis of the Influence of Price and Product Variation on Consumer Buying Interest at Tjap Djajakarta Malang
Authors: Akbar Muhammad Alfaisal , Rachmi Asminah
Published: February 2025

Two key factors that play a crucial role in the growth of Tjap Djajakarta Malang are the diversity of prices and products. The aim of this research is to investigate how Price and Product Variations impact Consumer Buying Interest in Tjap Djajakarta Malang, both individually and collectively. This study employed quantitative methods, focusing on two independent variables: Price (X1) and Product Variations (X2). The dependent variable in this study was Buying Interest (Y). Questionnaires were utilised to collect data from a sample of 98 respondents, selected using purposive sampling techniques. The analysis of the data included multiple regression, determination of coefficients, and testing of hypotheses.  According to the results of the t-test (partial), the first hypothesis (H1) has been confirmed. This suggests that the price factor (X1) has a partially positive effect on purchasing interest at Tjap Djajakarta. The second hypothesis (H2) has also been supported. This indicates that the product variety factor (X2) partially influences purchasing interest at Tjap Djajakarta Malang. Upon conducting the F-test (simultaneous) for the third hypothesis (H3), it was found that H3 is accepted while H0 is rejected.  Therefore, it can be inferred that both price and product range have a combined positive impact on consumer interest at Tjap Djajakarta Malang. Based on the findings of this study, it is recommended that Tjap Djajakarta retains its pricing strategy and expands its product offerings to attract more customers and become their preferred option.
Theory of Planned Behavior (TPB) Analysis: A Systematic Review of Key Factors of SMEs Financial Planning Behavior
Authors: Murdiono Ahmad , Winarno Agung , Pratikno Heri
Published: February 2025

Economic challenges are closely linked to discussions about micro, small, and medium enterprises (SMEs) due to their vital role in GDP contribution and job creation. Despite this, the progress of small businesses evolving into sustainable entities has been sluggish over the last decade. Therefore, it is crucial to conduct research aimed at bolstering the capabilities of SMEs in Indonesia. This research examines the financial behavior of SMEs through a Systematic Literature Review (SLR) approach. The goal is to pinpoint the factors that affect SMEs' financial behavior and their implications for financial planning. The SLR process consists of three key stages: identification, selection, and synthesis, with this study analyzing 15 pertinent articles. The results indicate that financial behavior is shaped by various factors, such as financial literacy, financial satisfaction, financial socialization, and mental accounting. This research serves as a resource for stakeholders in the SME sector, including researchers, practitioners, and policymakers, to enhance the capabilities of SMEs in Indonesia. Additionally, the findings aim to contribute to the global financial literature by offering a more organized behavioral finance model.
Introduction: “Assaying” the (Post-)Modern Essay
Authors: Baumlin James S. , Meyer Craig A.
Published: February 2025

"“To tell nothing but the truth—must, in all cases, be an unconditional moral law: to tell the whole truth is not equally so.” —Thomas De Quincey, Letter to the Editor, London Magazine, November 27, 1821
Dear reader. Yes, I am going to adopt the outmoded form of direct address to the reader—which was probably already quaint and artificial even to readers of eighteenth-century novels—to discuss terminology related to issues of identity. Some of you have, no doubt, already started to position yourselves for or against certain terms and phrases: authenticity, the true self, self-knowledge, free will, the search for identity, the social construction of identity, inner vs. outer, introversion vs. extraversion, private selves vs. social selves, modernism vs. postmodernism, the individual vs. culture, and so on. Such terms as these recur time and again in discussions of narrative. In narrative generally (and life-writing in particular), you might argue for the phrase “the social construction of identity” over the term “authenticity,” or vice versa. “It has to be one over the other,” you might say. Or, “I need definitions.” Readers have critiqued and problematized. You have used terms imprecisely, as if pointing to an object on the horizon. You have found them inadequate. All of them. The terms should have disappeared long ago, but you continue to use them, or at least some of them. This is probably because, as David Graeber and David Wengrow, who have studied cultures across the globe and through history, say, identity historically “came to be seen as a value in itself” (504). So, the terms linger."
Embodied Knowledge and Impenetrable Subjectivities: Lowndes’s and Hitchcock’s, The Lodger
Authors: Preslar Robert
Published: February 2025

This essay traces issues of embodiment through Marie Belloc Lowndes’ 1913 novel The Lodger, to the 1927 film adaptation of that novel, The Lodger: A Story of the London Fog, directed by Alfred Hitchcock. Despite the fact that Hitchcock’s adaptation departs from Lowndes’ novel in important ways, it is a work which builds upon and recontextualizes, rather than reconstructs, its source text. Further, among Hitchcock’s filmography, relatively little attention has been paid to The Lodger, and even less attention has been paid to its relationship to its source text. By focusing closely on the treatment of embodiment in both works, this essay demonstrates that the human body becomes a site of inscription and aesthetic production in ways that reflect the respective mediums of novel and film. In Lowndes’ novel, much of the narrative is conveyed through the embodied experiences of the protagonist, Mrs. Bunting, and the novel’s villain uses the bodies of his victims to inscribe his beliefs into culture. In Hitchcock’s film, the audience’s inability to access the protagonist’s innermost thoughts, even as the protagonist behaves in increasingly suspicious ways, highlights the limits of visual representation.
Investment output decision problem solved based on multi-dynamic combination algorithm
Authors: Hu* Zhenyu , Wang Pengbin
Published: February 2025

This article examined the development trends of various industries amid economic growth, analyzing the correlations between sectors, and constructed mathematical models to promote the upgrading of industries in China. The analysis focused on 9 core industry indicators and builds a Multi-Factor Industry Interaction Correlation Model (MFIICM). The Shapiro-Wilk test was first employed to examine the data distribution types for 2017 and 2019, calculating the significance level (P-value). It was found that P-value<0. 05 for all cases, indicating a normal distribution. Subsequently, the Spearman coefficients were calculated, and a heatmap was plotted. The correlation coefficient between manufacturing and construction industries was the highest at 0.97, while other industries showed trends of mutual promotion. Causal analysis was then introduced for cross-validation, with an average bar error rate of 0.04%. A topological relationship network was constructed, revealing that industries such as Agriculture, Accommodation, and Retail occupy central positions and exhibit significant systemic influence. To study the quantitative relationship between investment and the GDP of various industries, an Input-Output Economic Investment Efficiency Model (IEIEM) based on Leontief's theory was constructed, with the goal of maximizing GDP growth. Using factor analysis, 17 indicators were extracted as evaluation criteria to calculate the output value of each industry, among which other service industries had the highest output value of 379, 099.9. The deviation value Δ_"ratio " was then introduced for model evaluation, yielding a deviation of Δ_"ratio " =0.38 between the actual and theoretical values, thereby verifying the model's validity. Based on this, an analysis without restrictions by industry was conducted. Bi-Objective Programming Model (BOPM) was constructed, adding the objective of minimizing investment ratio changes and introducing the investment return to parameter β_i. The GA algorithm was used to BOPM, yielding β_i1=1.26,β_i2=1.09. The iterative update curves for the bi-objective model were plotted, showing consistent trends and high synergy. Specific allocation plans are detailed in the main text.
Studi Tingkat Konsistensi Penulisan Format Sitasi Pada Jurnal Ilmiah
Authors: Mawardi Agus Dian
Published: February 2025

Penelitian ini menggunakan pendekatan evaluatif. Sebagai evaluasi berarti hal ini merupakan bagian dari proses pembuatan keputusan, yaitu untuk membandingkan suatu kejadian, kegiatan, produk dengan standar dan program yang telah ditetapkan.  Tingkat konsistensi penulisan format sitasi pada jurnal terakreditasi Sinta nilai rata-rata 5,3 artikel atau sebesar 60,40%, sedangkan pada jurnal tidak terakreditasi nilai rata-rata 3,9 artikel atau sebesar 57,50%. Jika dibandingkan dengan jurnal terakreditasi, jurnal yang tidak terakreditasi tidak ada jurnal yang memiliki tingkat konsisensi 100% seperti pada jurnal terakreditasi Sinta. Namun, bila dilihat dari nilai rata-rata tingkat konsistensi, antara jurnal terakreditasi dan tidak terakreditasi terdapat selisih 2,90% saja, artinya di bawah angka 5%. Perlu dilakukan analisa statistik lanjutan pada analisa korelasi dan komparasi agar lebih mengetahui tingkat konsistensi lebih mendalam.
Financial Assistance Value for Equitable Access to Specialty Medications for Adults With Multiple Sclerosis Using Health System Pharmacy Services
Authors: Heppner Julie Wawrzyniak , Choma Andrew , Otto Tiffany , Collins Erin
Published: February 2025

BACKGROUND:

Contributing to the total economic burden of multiple sclerosis (MS) in the United States, the estimated direct medical costs of MS in 2019 were $63.3 billion, with medications accounting for over half of these expenses.1 MS disease-modifying therapy (DMT) costs can limit access, causing patients not to adhere to the medication regimen, which may lead to relapse, progression, disability, hospitalizations, and increased health care costs. Integrated health system specialty pharmacies (HSSPs) provide assistance to patients to alleviate the financial burden of specialty medications. MS center medication access specialists (MAS) obtain assistance for DMTs. This study quantifies the financial assistance obtained for patients with MS receiving medications through an integrated HSSP or infusion center.

METHODS:

This single-center retrospective chart review evaluated claims data for University of Rochester MS Center patients receiving financial assistance for MS specialty medications dispensed through the HSSP or infused at the MS center between July 20, 2020, and July 20, 2022. Descriptive statistics were used to assess all outcomes data.

RESULTS:

Patients received $3,377,172.96 in financial assistance. The median financial assistance used per patient per day of medication coverage was $2.08 (IQR, 12.02). The median out-of-pocket cost per patient per day after financial assistance was $0 (IQR, 0). Manufacturers provided the most financial support with a total contribution of $2,404,883.31, followed by grant foundations, which provided $574,659.27. Internal facility funds and the New York State Elderly Pharmaceutical Insurance Coverage program provided $241,377.97 and $156,252.41, respectively.

CONCLUSIONS:

Patients at this MS center were able to save thousands of dollars in out-of-pocket costs using financial assistance. Integrated HSSPs and MAS teams can help reduce the out-of-pocket cost of MS specialty medications, which may improve access to these medications.
Unique Health Care Delivery Considerations in Rural America
Authors: Palmer Kaitlyn , Cochran Jill , McGinley Marisa
Published: February 2025

Rural regions face significant health care disparities, including decreased access to insurance, increased access barriers to specialty care, worse medical outcomes, and increased mortality rates. People with multiple sclerosis (MS) residing in rural regions in the United States, as well as globally, face similar barriers to accessing MS care and experience poorer disease outcomes. Barriers to health care access include cultural and financial constraints, scarcity of services, a lack of trained physicians, insufficient public transport, and poor availability of broadband internet service. The Appalachian region, which contains a high degree of rurality, experiences increased disparities compared with the rest of the nation and can be used to highlight the unique challenges rural populations face. Appalachian residents can identify as private, and mistrust is a major factor in providing health care. Increasing the quantity and retention of Appalachian providers is essential to building trust. Still, it has proved difficult due to issues with compensation, taxes, malpractice fees, adverse actions against physicians, and high turnover rates. Telehealth interventions such as Project ECHO (Extension for Community Healthcare Outcomes) have improved rural outcomes in multiple diseases, including MS, but limited technology and technological literacy in rural areas impede the implementation of these interventions. Given the increasing rural population and ongoing disparities these communities face, there is a need to develop targeted interventions to improve access and outcomes in rural populations.
A Screening Method for Improved Single-Cell Protein Production
Authors:   , Raita Svetlana
Published: February 2025

The Thesis explores strategies to improve microbial protein synthesis, focusing on optimising fermentation processes and applying random mutagenesis. A database of amino acid biosynthesis inhibitors has been created, detailing their specificity, targeted amino acids, effects on microbial growth, treatment dosages, side effects, and usage conditions. A multi-criteria decision analysis of amino acid biosynthesis inhibitors was performed, accompanied by a comprehensive description of the materials, procedures, and equipment utilised in the experiments. Findings from the multi-criteria analysis and experimental studies are presented, highlighting the successful development of mutant strains with enhanced synthesis of essential amino acids. The amino acid profiles of the generated mutants were analysed and compared with those of the wild-type strain and single-cell protein-producing yeasts.
Unveiling the medicinal treasure of Habenaria intermedia D.Don: A review
Authors: Choudhary Kajal , Shelja Shelja , Kumar Jitender , Anukriti Anukriti
Published: February 2025

Plants are a significant source of traditional medicine because of their ability to prevent and treat human diseases. Habenaria intermedia is a terrestrial orchid of the Himalayas (1,200–4,000 m) known for immunomodulating properties and has great capability for cell regeneration. This orchid is the key component of Chyawanprash and Ayurvedic medicines, which are traditionally used as an appetizer, immune system booster, blood purifier, and brain tonic. The tubers are used in polyherbal formulations that are rich in antioxidants, strong in vital energy, and used to treat asthma, leprosy, and skin diseases. Different secondary metabolites, such as catechin, batatasin III, sinapic acid, β-sitosterol, gallic acid, p-coumaric acid, hydroxybenzoic acid, scopoletin, linoleic acid, and loroglossol extracted from the tubers and roots shows different pharmacological activities such as anti-bacterial, anti-stress, antioxidant, antimicrobial, and immunomodulatory. This review paper explores the medicinal uses, phytoconstituents, and pharmacological properties of H. intermedia. The natural population has decreased because of habitat degradation and destructive exploitation. Therefore, the habitat must be protected to preserve it in a native environment.
Bioactive compounds and antimalarial potential of sponge Aaptos suberitoides
Authors: Nanda Wahyuni E. , Gurning Kasta , Haryadi Winarto , Haryadi Winarto
Published: February 2025

Indonesia has abundant marine biota that can be used for various pharmacological activities. Among these, the sponge Aaptos suberitoides (A. suberitoides), which is rich in alkaloid compounds, and this group is reported to show antiplasmodium activity. This research aims to identify alkaloid compounds using Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) and test their antimalarial activity in vitro and molecular docking. Extraction was done using the mixture of dichloromethane (DCM) and methanol (1:1). The DCM phase extraction was followed by gradual partitioning with ethyl acetate and water. Phytochemical screening was performed on the dried extracts. The ethyl acetate extract was purified using column chromatography. The purified fractions were tested in vitro for antimalarial activity, and the most active fraction was subjected to compound identification using LC-HRMS as well as molecular docking studies on the 1J3K and 1J3J proteins. The results of the phytochemical screening of the ethyl acetate extract showed that it contained alkaloids with an IC50 value of 0.8189 μg/ml. Fraction number 12 resulting from the purification of ethyl acetate extract has the most potential as an antimalarial, with IC50 values of 00.423± 0.243 μg/ml and 10.21 ± 3.63 μg/ml, in the heme polymerization and antipalsmodium methods, respectively). Compounds identified in the most potent fraction were konbamidin, demethylaaptamine, penicyclone D, and two compounds with codes NP-011220 and NP-013736, which are thought to be new compounds. The results of studies using a molecular docking approach show that demethylaaptamine and penicyclone D are active against malaria proteins coded 1J3K and code 1J3J, respectively. Bioactive compounds from the sponge A. suberitoides can be developed into potential active ingredients for the treatment of malaria from natural marine biota.
Human Brain-Wide Activation of Sleep Rhythms
Authors: Wang Haiteng , Zou Qihong , Zhang Jinbo , Gao Jia-Hong , Liu Yunzhe
Published: February 2025

During sleep, our brain undergoes highly synchronized activity, orchestrated by distinct neural rhythms. Little is known about the associated brain activation during these sleep rhythms, and even less about their functional implications. In this study, we investigated the brain-wide activation underlying human sleep rhythms by employing simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) in 107 participants during overnight sleep. We identified a significant coupling between slow oscillations (SO) and spindle events during non-rapid eye movement (NREM) sleep, particularly at the UP-state of SOs. This coupling was associated with increased activation in the thalamus and hippocampus, showing a brain-wide activation that resembles episodic memory processing, yet is distinctly dissociated from task-related activation. Moreover, this SO-spindle coupling was linked to a selective increase in functional connectivity from the hippocampus to the thalamus, and from the thalamus to the neocortex, particularly the medial prefrontal cortex. These findings suggest that the thalamus plays a crucial role in coordinating the hippocampal-cortical dialogue during sleep.
Newly discovered and conserved role of IgM against viral infection in an early vertebrate
Authors: Kong Weiguang , Wang Xinyou , Ding Guangyi , Yang Peng , Shi Yong , Cai Chang , Yang Xinyi , Cheng Gaofeng , Takizawa Fumio , Xu Zhen
Published: February 2025

IgM emerged in jawed vertebrates 500 Mya and remains the most evolutionarily conserved antibody class. However, despite extensive studies on IgM as an ancient antiviral weapon in warm-blooded vertebrates, its role and mechanisms in combating viral infections in early vertebrates remain poorly understood. Here, we found that significant virus-specific sIgM titers were generated in serum and gut mucus of teleost fish that survived infection, and fish lacking sIgM were more susceptible to viral infection. These results challenge the paradigm that IgM and IgT are specialized to systemic and mucosal immunity, respectively. More crucially, we discovered a previously unknown role of sIgM in viral neutralization and clarified the mechanism through which teleost sIgM blocks viral infection by directly targeting viral particles. From an evolutionary perspective, our findings indicate that both primitive and modern sIgM adhere to conserved principles in the development of specialized antiviral immunity.