bluuebunny/crossref_metadata_2025 huggingface dataset:
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal
Lobe Epilepsy Following Systemic Administration of Dental Pulp
Stem Cells and Bone Marrow Mesenchymal Stem Cells
Authors: Senthilkumar Sivapriya , Maiya Krishnamoorthi , Jain Nishta Kusum , Mata Sundeep , Mangaonkar Snehal , Prabhu Prajnya , Rai Kiranmai S. , Kutty Bindu M. , Dhanushkodi Anandh
Published: October 2022

Introduction:

We aim to investigate whether timed systemic administration of dental pulp
stem cells (DPSCs) or bone marrow mesenchymal stem cells (BM-MSCs) with status epilepticus (SE)
induced blood-brain barrier (BBB) damage could facilitate the CNS homing of DPSCs/BM-MSCs and
mitigate neurodegeneration, neuroinflammation and neuropsychiatric comorbidities in an animal
model of Temporal Lobe epilepsy (TLE).

Background:

Cognitive impairments, altered emotional responsiveness, depression, and anxiety are
the common neuropsychiatric co-morbidities observed in TLE patients. Mesenchymal stem cells
(MSCs) transplantation has gained immense attention in treating TLE, as ~30% of patients do not
respond to anti-epileptic drugs. While MSCs are known to cross the BBB, better CNS homing and
therapeutic effects could be achieved when the systemic administration of MSC is timed with BBB
damage following SE.

Objectives:

The objectives of the present study are to investigate the effects of systemic administration of
DPSCs/BM-MSCs timed with BBB damage on CNS homing of DPSCs/BM-MSCs, neurodegeneration,
neuroinflammation and neuropsychiatric comorbidities in an animal model of TLE.

Methodology:

We first assessed the BBB leakage following kainic acid-induced SE and timed the
intravenous administration of DPSCs/BM-MSCs to understand the CNS homing/engraftment potential
of DPSCs/BM-MSCs and their potential to mitigate neurodegeneration, neuroinflammation and
neuropsychiatric comorbidities.

Results:

Our results revealed that systemic administration of DPSCs/BM-MSCs attenuated
neurodegeneration, neuroinflammation, and ameliorated neuropsychiatric comorbidities. Three
months following intravenous administration of DPSCs/BM-MSCs, we observed a negligible number
of engrafted cells in the corpus callosum, sub-granular zone, and sub-ventricular zone.

Conclusion:

Thus, it is evident that functional recovery is still achievable despite poor engraftment of
MSCs into CNS following systemic administration.
Serum Uric Acid Levels Are Associated With Macula Microvasculature
Changes In Hypertensive White Matter Hyperintensity Patients
Authors: Zhao Yitian , Liang Hui , Wei Ruili , Xie Jianyang , Meng Fangxia , He Fangping , Liu Jiang
Published: October 2022

Purpose:

To characterize the macula microvasculature using fractal dimension (FD) in
hypertensive white matter hyperintensity (WMH) participants and explore the association between
the microvascular changes and serum uric acid levels.

Methods:

Thirty-eight WMH participants were dementia and stroke-free, and 37 healthy controls
were enrolled. Optical coherence tomographic angiography (OCTA) was used to image the superficial
vascular complex (SVC), deep vascular complex (DVC), and inner vascular complex (IVC) in a
2.5-mm diameter concentric circle (excluding the foveal avascular zone FAZ). A commercial algorithm
was used to quantify the complexity and density of the three capillary layers by fractal analysis.

Results:

WMH participants showed significantly lower FD value in the SVC (P = 0.002), DVC (P <
0.001) and IVC (P = 0.012) macula microvasculature compared with control group. After adjusting
for risk factors (hypertension, diabetes, age and gender) SVC (P = 0.035) and IVC (P = 0.030) significantly
correlated with serum uric acid.

Conclusions:

Serum uric acid levels are associated with microvascular changes in WMH. Fractal
dimension based on OCTA imaging could help quantitatively characterize the macula microvasculature
changes in WMH and may be a potential screening tool to detect serum uric acid level changes.
Exploration of the Mechanism of Tripterygium Wilfordii in the Treatment
of Myocardial Fibrosis Based on Network Pharmacology and Molecular
Docking
Authors: Ming Yang , Jiachen Liu , Tao Guo , Zhihui Wang
Published: October 2022

Background:

A network pharmacology study on the biological action of tripterygium wilfordii on myocardial fibrosis（MF）.

Methods:

The effective components and potential targets of tripterygium wilfordii were screened from the TCMSP database to develop a combination target network. A protein-protein interaction network was constructed by analyzing the interaction between tripterygium wilfordii and MF, and then the Gene Ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed. Furthermore, molecular docking was utilized to verify the results of the network analysis.

Results:

It was predicted that MF has 29 components that contribute to its effectiveness, as well as 87 potential targets. It is predicted that Tripterygium wilfordii has 29 active components and 87 potential targets for the treatment of MF. The principal active components of tripterygium wilfordii include kaempferol, β-sitosterol, triptolide, and Nobiletin. Signaling pathways: AGE-RAGE, PI3K-Akt, and MAPK may be involved in the mechanism of its action.7 Seven key targets (TNF, STAT3, AKT1, TP53, VEGFA, CASP3, STAT1) are possibly involved in the treatment of MF by tripterygium wilfordii.

Conclusion:

This study shows the complex network relationship between multiple components, multiple targets, and multiple pathways of Tripterygium wilfordii in treating MF.
Interplay between SARS-CoV-2 and Cancer: Plausible Risk Factors, Cellular
Immune Responses, Cancer Directed Therapy- Current Challenges
Authors: Mukherjee Sukhes , Ray Suman Kumar
Published: October 2022

COVID-19 has created tremendous societal upheaval, resulting in a global overhaul of healthcare systems. According to new evidence, the COVID-19 pandemic has the potential to aggravate pre-existing inequities, particularly among cancer patients. The COVID-19 pandemic has had a disproportionately negative impact on cancer patients. The unfavorable outcomes in cancer patients who contract COVID-19, the impact of the COVID-19 pandemic on cancer care delivery, and the significant disruption of cancer research are all examples of this consequence. On the other hand, patients with cancer are a diverse group, and new research has identified characteristics that allow for risk categorization of cancer patients to optimize care. Variable access to telemedicine, timely diagnosis, and treatment access are all possible drivers of unequal cancer survival as a result of the epidemic. Despite oncology associations presenting guidelines on cancer care during the pandemic, the magnitude of potential therapy advantages, therapeutic purpose, and access to care all play a role in prioritizing cancer medicines. This review focuses on evidence related to COVID-19 and cancer, such as the molecular interactions between the two diseases and practical therapeutic suggestions for cancer patients during the pandemic. We also explore the pandemic's possible long-term influence on cancer care due to its negative impact on cancer research, as well as biological discoveries from the cancer research community that could aid in the development of novel therapeutics for all COVID-19 patients.
Hepatologists’ Awareness and Knowledge of NAFLD and the Familiarity
with Renaming NAFLD to MAFLD
Authors: Alem Shereen Abdel , Fouad Yasser , AbdAllah Mohamed , Attia Dina , Kamal Inas , Said Ebada , Gomaa Ahmed , Abd-Elsalam Sherief M. , Gaber Yasmine
Published: October 2022

Background & Aims:

Non-alcoholic fatty liver disease (NAFLD) is an emerging epidemic;
it is a negative diagnosis that depends mainly on the presence of hepatic steatosis with or
without inflammation after the exclusion of other chronic liver diseases and excess alcohol intake.
However, the new definition of MAFLD is a shift towards a diagnosis of inclusion based on
the presence of metabolic dysfunction, regardless of alcohol consumption or other concomitant
liver diseases. Given the growing relevance of the disease, data on hepatologists' views and understanding
of NAFLD are limited, we aimed to determine hepatologists' awareness and expertise
of NAFLD screening, diagnosis, and therapeutic options as well as the influence of changing
the NAFLD name to MAFLD on awareness of the fatty liver disease (FLD).

Objective:

Most of the hepatologists agreed that NAFLD can cause serious hepatic illness and
may be linked to metabolic risk factors, necessitating a multidisciplinary approach to treatment.
Hepatologists have a poor understanding of NAFLD care. The shift in terminology from NAFLD
to MAFLD will be more known to hepatologists, and it may offer better awareness of FLD.

Methods:

A multicenter online questionnaire of 655 hepatologists was carried out, giving a sample
of 207 respondents. A survey composed of 36 questions was used to assess the level of hepatologists'
awareness and practices in the screening, diagnosis, and management of
NAFLD/MAFLD, as well as their familiarity with the nomenclature change from NAFLD to
MAFLD.

Results:

A total of 207 hepatologists were included, of which 107 (51.4%) were males, with a
mean age was 36.4 years. 50.2% (n = 104) of the hepatologists were oriented with NAFLD. Only
41 (19.8%) realized that NAFLD may frequently result in severe hepatic disease. NAFLD is rarely
screened by the majority of the participating hepatologists (118, 57%), and (135, 65.2%) of
them use liver biopsy for diagnosis of NAFLD. In (104, 50.2%) hepatologists, changing the nomenclature
of NAFLD was relatively familiar. Furthermore, 71.9% of hepatologists thought that
the new nomenclature offers a better awareness of FLD.

Conclusion:

A small percentage of hepatologists agreed that NAFLD can cause serious hepatic
illness and may be linked to metabolic risk factors, and around half of them realize that NAFLD
necessitates a multidisciplinary approach to treatment. Hepatologists have a poor understanding
of NAFLD care. The shift in terminology from NAFLD to MAFLD will be more known to hepatologists,
and it may offer better awareness of FLD.
Synthesis and Evaluation of New Derivatives of Busulfan as an Anti-carcinogenic Drug against k562 Cancer Cells Using the AO / PI Method
Authors: Jabbari Hadi , Khosravi Setareh , Azimi Saeid
Published: October 2022

Background:

Busulfan is a DNA alkylating drug used to treat chronic myeloid leukemia (CML). This type of leukemia affects bone marrow cells or myocytes, which make up bone marrow tissue having a chronic process. Leukemia is a progressive and malignant disease of the body's hematopoietic organs. The disease is caused by the underdevelopment and proliferation of white blood cells and their precursors in the blood and bone marrow.

Objective:

The synthesis of Busulfan drug and the conjugation of Busulfan from the anomeric position of acetylated galactose as a new derivative of Busulfan and its anti-cancer effect on K562 cancer cells are among the most important objectives of this study.

Methods:

In this work, galactose was acetylated with acetic anhydride in the presence of sodium acetate, then the anomeric position of acetylated carbohydrate deacetylated using imidazole to obtain the final product through the reaction of Busulfan. Anti-cancer activity of the product was evaluated against K562 cancer cells. The proliferation and survival of K562 cancer cells and PBMCs (peripheral blood mononuclear cells) using the AO/PI method were studied. Furthermore, 1- (2, 3, 4, 6-tetra-O-acetyl-Iβ-D-galactopyranosyl) -4- (methyl sulfonyl oxy) butane was evaluated against cancer cells as a new derivative.

Results:

In this study, the Acridine Orange / Propidium Iodide (AO/PI) method was performed using fluorescence microscopy to evaluate the efficacy of a synthesized product. The effective dose of 0.02 mg/L of 1- (2, 3, 4, 6-tetra-O-acetyl-Iβ-D-galactopyranosyl) -4- (methyl sulfonyl oxy) butane was observed to cause 96% of cancer cells necrosis.

Conclusion:

1- (2, 3, 4, 6-tetra-O-acetyl-Iβ-D-galactopyranosyl) -4- (methyl sulfonyl oxy) butane as a new derivative of Busulfan acts non-specifically in the cell cycle by inhibiting DNA activity by alkylation and binding to the DNA strand. Alkylating agents usually bind an alkyl group to the number seven nitrogen atom in the guanine nucleotide in a DNA molecule.
Organoselenium Compounds as Potential Therapeutic Agents for Treating
Brain Disorders
Authors: Kothapalli Lata , Sarode Varsha , Thomas Asha , Bhole Ritesh
Published: October 2022

Among the inorganic elements, selenium is one of the essential entities required in trace amounts. Selenium (Se) has a vital role to play in brain physiology. It is well demonstrated that an abnormal level of selenium is the cause of the pathogenesis of various neurodegenerative diseases. As selenium levels are age-dependent, deficiency of Se is well correlated with cognitive disability with aging which further correlates with Alzheimer’s disease. Organoselenium compounds are considered an essential therapeutic class of compounds as they have gained a wide spectrum of applications in biotransformation and are well-studied by several researchers. In recent years, a detailed analysis of the effectiveness of organoselenium compounds in attenuating disease are done. A literature search on PubMed, Embase, and Scopus databases was done using the keywords “organoselenium compounds, brain disorder, Alzheimer's, Parkinson's' disease, neurodegenerative disorders. The introduction of selenium as a functional group in aryl and heteroaryl compounds has given the lead for treating various brain ailments including Alzheimer's disease, depression, anxiety, Parkinson’s disease, etc. The organoselenium compounds are also potent antioxidants and are promising chemical entities for further studies.
Effect of Volume Fraction hybrid composite duck feathers (Anas Plathycus Borneo) - Rat Purun Fiber (Eleocharis Dulcis) With Matrix Polyester On Tensile And Bending Strength
Authors: Nugraha Andy , Syarief Akhmad , Fadliyanur Fadliyanur , Suryanta Dhanu , Ramadhasari Aulia , Setiawan Bayu
Published: October 2022

Alabio ducks (Anas Plathycus Borneo) developed in the Alabio area of Hulu Sungai Utara Regency, South Kalimantan with a duck population in 2006 recorded at 3,487,002 heads. So far, alabio ducks have only been used for meat and eggs, even though the feather part of this one poultry can also be used as a composite raw material because of its relatively strong and elastic nature. To improve the quality of the composite, duck feathers are combined with rat purun fibers (eleocharis dulcis) so that they become Hybrid composites. Fraksi volume Hybrid composite Duck Feathers and Rat Purun Fiber are as follows 10% : 90 %, 20% : 80%, 30% : 70%, 40% : 60%, 50% : 50%, 60% : 40%, 70% : 30%, 80% : 20%, 90% : 10%. This study used experimental methods. From the results of the study, it is known that the value of tensile and tensile strength stress and bending strength decreased as the percentage of rat purun fibers decreased compared to the percentage of duck feathers
Factors Affecting Commuters' Intentions in Using Park and Ride (P&R) Facilities Based on Theory of Planned Behavior
Authors: Irawati Sara , Agustin Imma , Dwi Ari Ismu
Published: October 2022

Park and Ride (P&R) is a form of transportation demand management closely related to commuting activities. Several developed countries, such as the UK, Canada, China, and Hong Kong already implemented P&R with a high level of effectiveness and success in overcoming the congestion problems in the city center, low use of public transportation, and air pollution. However, in developing countries, the various positive impacts of P&R still have not been able to encourage commuters' intentions to use these facilities. The level of P&R use at Sidoarjo Station is still relatively low (44.3%). Behavioral is one of several keys to the success of P&R that depends on intention and ability. The intention is the result of knowledge, social, and infrastructure that can support the use of public transport and P&R. This study aims to identify factors that can influence commuters' intentions to use P&R at Sidoarjo Station based on the theory of planned behavior using SEM analysis. The results showed that P&R and public transportation conditions as perceived behavioral control were the most influential factors on commuter intentions. The conditions of public transportation (including availability and location) and the quality of P&R facilities are also essential considerations for commuters using P&R
Food Bar corn flour Combination sebagai Pangan Darurat
Authors: Yulianti Naning
Published: October 2022

Pangan darurat adalah pangan yang dalam keadaan darurat diharapkan dapat memenuhi kebuttuhan kalori sebesar 233-250 kkal/50 gram bahan. Produk pangan darurat salah satunya adalah food bar. Bahan baku yang digunakan dalam pembuatan food bar ini berasal dari tepung jagung dan bahan tambahan (gula jawa, madu, keripik ubi ungu, mix fruits, kacang tanah, selai kacang, keju, coklat, corn flake, rice crispy). Tepung jagung dipilih karena selama ini pemanfaatan tepung jagung masih terbatas untuk bahan pangan. Padahal kandungan gizinya dapat dimanfaatkan dalam pengembangan produk food bar. Selain itu jagung merupakan penyumbang terbesar kedua setelah bahan pangan padi dalam subsektor tanaman pangan. Tujuan penelitian ini adalah untuk mengetahui kualitas food bar yang baik sesuai dengan syarat pangan darurat dan daya terima masyarakat. Proses pengolahan terutama penggunaan suhu yang tepat sehingga menghasilkan produk yang baik. Uji yang dilakukan adalah uji panelis terhadap produk yang dibuat dan pengamatan secara langsung pada proses pembuatan food bar. Hasil penelitian menunjukan bahwa pengovenan suhu yang tepat adalah 80 0C selama 20 menit diikuti dengan temperature 50 0C selama 15 menit untuk produk food bar formula 1 dan temperature 80 0C selama 20 menit diikuti dengan temperature 50 0C selama 40 menit untuk formula 2. Hasil penelitian uji panelis menunjukkan bahwa produk sudah memenuhi kriteria produk yang baik, yang masih perlu ditingkatkan adalah penggunaan tepung jagung yang berkualitas baik sehingga menghasilkan produk food bar yang mempunyai aroma jagung yang kuat.
KONTRIBUSI HASIL BELAJAR PRODUKSI BUSANA DAN PENGETAHUAN KEWIRAUSAHAAN TERHADAP KESIAPAN MAHASISWA MEMBUKA USAHA BUTIK
Authors: Retnasari Dian
Published: October 2022

Penelitian ini bertujuan untuk mengetahui kesiapan mahasiswa membuka usaha butik ditinjau dari kompetensi produksi busana custom made, produksi busana konveksi, dan pengetahuan kewirausahaan. Penelitian ini menggunakan pendekatan kuantitatif. Populasi penelitian adalah seluruh mahasiswa Prodi Teknik Busana dan Pendidikan Teknik Busana Universitas Negeri Yogyakarta angkatan 2017 yang berjumlah 109 mahasiswa, sampel penelitian sebanyak 89 mahasiswa diambil menggunakan teknik proportional random sampling. Teknik pengumpulan data menggunakan angket, tes, dan dokumentasi. Data yang diperoleh dianalisis menggunakan analisis statistik inferensial. Teknik analisis statistik inferensial yang digunakan untuk menguji hipotesis menggunakan teknik analisis korelasi parsial dan regresi linier berganda. Hasil penelitian mengungkapkan bahwa ada pengaruh yang signifikan baik secara parsial maupun simultan kompetensi produksi busana cuctom made, produksi busana konveksi, dan pengetahuan kewirausahaan terhadap kesiapan berwirausaha. Hal tersebut ditunjukkan dengan nilai sumbangan dari kompetensi produksi busana custom made sebesar 24,15%, produksi busana konveksi 10,28% dan pengetahuan kewirausahaan sebesar 12,57 %, jadi total sumbangannya sebesar 47%, sedangkan 53% merupakan sumbangan dari variabel lain yang tidak diteliti
KESESUAIAN KOMPETENSI LULUSAN PRODI PENDIDIKAN TATA BOGA TERHADAP KKNI DAN BAHAN KAJIAN
Authors: Windradini Irdiana
Published: October 2022

Kerangka Kualifikasi Nasional Indonesia (KKNI) digunakan sebagai bentuk pengembangan kurikulum sebagai bahan penyusun kompetensi lulusan dan bahan kajian menurut jenjang kualifikasinya. Tujuan penelitian ini adalah untuk mendeskripsikan: (1) tingkat kesesuaian kompetensi lulusan Program Studi Pendidikan Tata Boga dengan KKNI, dan (2) tingkat kesesuaian kompetensi lulusan dengan bahan kajian Program Studi Pendidikan Tata Boga berdasarkan parameter sikap, keterampilan umum, keterampilan khusus, dan penguasaan pengetahuan. Metode penelitian adalah penelitian evaluatif. Sumber data adalah dokumen kurikulum Program Studi Pendidikan Tata Boga Universitas Negeri Malang. Data dikumpulkan menggunakan instrumen penelitian berupa kuesioner dan dianalisis menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa: (1) tingkat kesesuaian kompetensi lulusan Program Studi Pendidikan Tata Boga dengan KKNI termasuk dalam kategori sangat sesuai, dan (2) tingkat kesesuaian kompetensi lulusan dengan bahan kajian pada parameter sikap dan penguasaan pengetahuan termasuk dalam kategori sesuai, sedangkan parameter keterampilan umum dan keterampilan khusus termasuk dalam kategori sangat sesuai.
DEVELOPING YOUNG ENTREPRENEURS IN THE FASHION FIELD THROUGH EXTRACURRICULARS ACTIVITIES
Authors: Zahro Siti , Lyau Nyan-Myau , Nurhadi Didik
Published: October 2022

Unemployed youths constitute major problems in many countries. Ideally, they should get themselves prepared to respond to future challenges. Entrepreneurship is one of the ways they can get jobs or establish their own firms. However, to be successful entrepreneurs, they should go through a gradual process that can be prepared in the high school before they continue to the university. Thus, high school stakeholders need to develop their students’ entrepreneurial flair through a learning strategy on extracurricular activities supported by lesson plans, learning processes, and evaluation. This paper aims to give a clear picture of steps to hone students’ entrepreneurial skills through extracurricular activities in fashion field stimulated to prepare them for being good entrepreneurs. This program of character building depends on favorable education environments and supports from leaders, teachers and students’ parents.
PENERAPAN SEAMLESS TUCKS PADA BUSANA PESTA WANITA DAN PRIA DENGAN TEMA THE GRAY HOLE
Authors: Indarti Indarti , Putri Aprillia Anggi Wati
Published: October 2022

Tujuan penelitian adalah untuk mengetahui proses pembuatan dan hasil jadi semless tucks pada busana pesta wanita dan pria dengan tema the gray hole. Metode yang digunakan adalah three stage design process (LaBat Sokolowski, 1999), yang terdiri dari 3 tahapan yaitu problem definition research, creative exploration, dan implementation. Dari hasil yang diperoleh, seamless tucks bisa digunakan sebagai detail busana pesta baik untuk wanita maupun pria. Proses pembuatan seamless tucks  menggunakan jahitan tangan (tusuk jelujur) dengan mengikuti pola yang telah digambar atau dijiplak pada permukaan kain. Adanya lipatan kain yang dijahit dalam membentuk seamless tucks, maka diperlukan penambahan lebar dan panjang kain, untuk motif yang penuh diperlukan dua kali panjang dan lebar kain. Hasil jadi pada busana wanita sesuai dengan konsep perancangan antara lain menggunakan siluet H, penerapan seamless tucks berbentuk lingkaran menyerupai lubang pori-pori pada batu apung diterapkan pada keseluruhan permukaan cape dan menjadi center of interest dari keseluruhan look pada gaun pesta. Hasil jadi pada busana pria sesuai dengan konsep perancangan yaitu menggunakan siluet busana formal yang klasik berupa setelan jas (suit). Penerapan seamless tucks berbentuk lingkaran diterapkan pada kelepak kerah (peak lapel) dan kelepak saku. Hasil jadi busana secara keseluruhan telah memenuhi beberapa kriteria prinsip desain.
AKTIVITAS ANTI BAKTERI MANDI CELUP DAUN BINAHONG DALAM MEMBANTU MENGURANGI JERAWAT PUNGGUNG
Authors: Siregar Ika Pranita
Published: October 2022

Meningkatnya resistensi bakteri penyebab penyakit infeksi kulit seperti jerawat punggung terhadap berbagai antibiotik mengakibatkan kesulitan yang lebih besar dalam pengobatannya. Hal ini mendorong dilakukan pengkajian dan penelitian untuk menemukan obat alternatif selain antibiotik dari bahan kimia, khususnya dari bahan alam yang lebih poten terhadap bakteri. Daun Binahong (Anredera cordifolia (Ten.) Steenis) memiliki khasiat sebagai antibakteri.Salah satu penyebab resistensi antibiotik adalah ketidakpatuhan pasien terhadap penggunaan antibiotik. Ketidakpatuhan pasien disebabkan karena kurangnya pengetahuan tentang penggunaan dan regimen dosis antibiotik. Hal ini mendorong diciptakannya suatu produk antibiotik herbal baru yang lebih aman dan mudah ntuk digunakan. Bentuk sediaan mandi rempah dalam bentuk celup dapat digunakan untuk memudahkan aplikasi penggunaan antibotik dengan tepat dan aman Efektivitas serbuk daun Binahong pada kulit yang terinfeksi bakteri seperti jerawat semakin besar dengan semakin tinggi konsentrasi ekstrak daun binahong. Dengan demikian dapat diberi perlakuan terhadap klien yang terinfeksi bakteri dengan kadar simplisia daun binahong yang berbeda (meningkat) pada sediaan mandi celup herbal dan pembanding yaitu sediaan mandi celup herbal tanpa pemberiaan simplisia daun binahong (kontrol negatif) dan sediaan mandi celup herbal ditambah antibiotik kimia (kontrol positif).
RESPON KAUM WANITA MUSLIMAH DI DESA KLAKAH KABUPATEN LUMAJANG TERHADAP HASIL PEMBUATAN JILBAB COVID INSTANT
Authors: Hidayati Lutfiyah , TR Imami , Nashikhah Ma’rifatun , Kharnolis Mein , Nahari Inty , Arifiana Deny
Published: October 2022

The corona virus pandemic is spreading very quickly, including Lumajang Regency. There are seven villages in Lumajang Regency that are included in the red zone affected by the virus. Various efforts have been socialized to the public to prevent contracting the virus, one of which is by recommending the use of personal protective equipment. The purpose of this study is to describe the response of women in Klakah Village, Lumajang to the instant Covid hijab produced by the Unesa PKM Team in the Community Service program. This research is a descriptive study carried out in October - December 2020. The number of research subjects was 50 women from Klakah village, Klakah sub-district, Lumajang Regency. Method of data collection with a questionnaire. The research instrument was in the form of a response questionnaire in the form of a Google form which was distributed through the Whatsapp social media application. The data analysis method used descriptive analysis to calculate the mean value. The results of the study stated that the response of women in Klakah village, Klakah sub-district, Lumajang to the instant covid hijab product reached an average of 91%, included in the very good criteria
SEKSUALITAS PEREMPUAN DAN WACANA DOMINAN PATRIARKI DALAM BEAUTIFUL YOU KARYA CHUCK PALAHNIUK
Authors: Dinanti Putri Ayienda , Tjahjani Joesana
Published: October 2022

Patriarki adalah salah satu sistem sosial yang mengatur di beberapa negara. Imbas dari sistem patriarki, perempuan sering mengalami dominasi dan tekanan yang ditimbulkan oleh laki-laki. Hal tersebut dilakukan melalui penguasaan terhadap seksualitas perempuan. Mengacu pada latar belakang tersebut, penelitian ini bertujuan mengungkap hubungan seksualitas perempuan dengan wacana patriarki di dalam karya sastra, khususnya novel Beautiful You. Karya tersebut ditulis oleh Chuck Palahniuk di tahun 2014 dan termasuk ke dalam jajaran sastra kontemporer Amerika. Metode berlandaskan kualitatif dipilih ke dalam penelitian untuk mendapatkan gambaran analisis yang lebih rinci. Tulisan ini menggunakan pendekatan struktural dan kritik sastra feminis. Teori sekuen Schmitt dan Viala, serta bagan fungsional transformasi Greimas digunakan untuk membongkar struktur dan strategi naratif teks. Teori feminisme eksitensialis milik Beauvoir kemudian dipaparkan untuk menemukan ideologi dalam teks. Hasil penelitian menunjukkan bahwa: pertama, struktur teks dan strategi naratif memang mengindikasikan kehadiran dominasi laki-laki di sepanjang cerita. Kedua, laki-laki mendominasi melalui tubuh dan seksualitas perempuan. Ketiga, dominasi tersebut berhubungan erat dengan adopsi wacana patriarki yang kemudian menjadi ideologi dalam teks. Kata kunci: dominasi, kesusastraan, patriarki, perempuan, seksualitasWOMEN’S SEXUALITY AND DOMINANT DISCOURSE OF PATRIARCHY IN BEAUTIFUL YOU BY CHUCK PALAHNIUK AbstractPatriarchy is one of the social systems that governs in several countries. As a result of the patriarchal system, women often experience domination and pressure caused by men. This is done through domination of women's sexuality. Referring to this background, this study is aimed at revealing the relationship between women's sexuality and patriarchal discourses in literary works, especially in the novel Beautiful You. The work is written by Chuck Palahniuk in 2014 and belongs to the ranks of contemporary American literature. A qualitative based method is selected in the study to obtain a more detailed description of the analysis. The study uses a structural approach and feminist literary criticism. Schmitt and Viala's sequence theory, as well as Greimas’ transformation functional chart are used to unravel the text structure and narrative strategy. Beauvoir's theory on existentialist feminism is presented to find ideologies in the text. The results of the research show that: first, the structure of the text and the narrative strategy indeed indicate the presence of male dominance throughout the story. Second, men dominate through women's bodies and sexuality. Third, that dominance is closely related to the adoption of patriarchal discourses which later become an ideology in the text. Keywords: domination, literature, patriarchy, women, sexuality
LITERASI MEMBACA MAHASISWA OLAHRAGA
Authors: Mulyawan Rizki , Guntur Guntur , Rismayanthi Cerika
Published: October 2022

Literasi menjadi bagian penting bagi masa depan seseorang. Pengetahuan akan lebih luas apabila kebiasaan membaca sudah ditanamkan sejak dini. Sayangnya, tingkat literasi masyarakat masih sangat rendah, maka dari itu muncul keinginan dalam mendalami bagaimana persepsi mahasiswa di lingkungan pendidikan tinggi tentang kebiasaan dalam literasi. Lebih spesifik, subjek penelitian berasal dari mahasiswa olahraga yang mengikuti perkuliahan telaah literatur. Terdapat sejumlah 85 orang yang terlibat dalam studi deskriptif secara sukarela. Pemilihan subjek penelitian dilakukan melalui teknik purposive sampling. Pengumpulan data dengan cara observasi, angket, dan wawancara. Studi pendahuluan ini menghasilkan gambaran tentang kebiasaan membaca mahasiswa olahraga yang masih sangat rendah, 10-15 menit waktu membaca dilakukan oleh mahasiswa olahraga dengan presentase sebanyak 36,5%, diikuti oleh kebiasaan membaca dalam rentang 5 – 10 menit, 15 – 30 menit, di bawah 5 menit dan di atas 30 menit yaitu 34,1%, 15,3%, 9,4%, dan 4,7% dari mahasiswa olahraga yang terlibat pada studi pendahuluan ini. Lalu, mayoritas mahasiswa hanya membaca 1 kali sehari mencapai 64%. Meskipun begitu, pengetahuan tentang mencari informasi sudah mencakup sumber nasional dan/atau internasional. Hasil survey studi pendahuluan ini menyimpulkan bahwa minat baca mahasiswa olahraga sangat rendah, sehingga perlu cara untuk memperbaiki tingkat literasi mahasiswa olahraga untuk lebih membuka wawasan.
Sistem sapaan di lingkungan masyarakat desa Masaran kabupaten Sumenep Madura (kajian sosiolinguistik)
Authors: Dzulkifli Mohammad
Published: October 2022

Artikel ini mengkaji fenomena kebahasaan dalam sistem sapaan bahasa Madura di kalangan masyarakat Masaran. Tujuan yang hendak dicapai adalah untuk mendeskripsikan bentuk-bentuk sapaan dalam tuturan masyarakat desa Masaran dan perkembangannya hingga saat ini. Penelitian ini tergolong penelitian deskriptif kualitatif dengan metode simak catat dan observasi. Sumber data pada penelitian ini adalah tuturan bahasa Madura di lingkungan masyarakat desa Masaran baik secara lisan maupun tulisan di media sosial (WA). Hasil penelitian ini menunjukkan beberapa bentuk sapaan di ranah kekeluargaan, seperti Aba/abi, Bapak, eppa’, mama’, ummi, ebok, embu’, emma’, nyaih/emba bini’, kaeh/ emba lake’, juju’, emba’, embug, eyyu, mas, kaka’, caca’, mak,), ale’, ade’, anum, om, Pa’+nama panggilan, elle’/le’. Adapun untuk sapaan di ranah non-keluarga terdapat sapaan seperti: cong, ke’, num, ka’, keh, nyi, pa’, ajjih. Sapaan untuk pronomina persona satu seperti, engko’, sengko’, kuleh, guleh, kauleh, abdinah. Adapun untuk pronomina persona kedua seperti: be’en, empiyan, sampiyan, ajunan, panjenengan. Untuk pronomina persona ketiga menggunakan nama asli, nama anak pertama, jejulug atau laqob. Bentuk sapaan kalangan remaja di media grup WA seperti: ni’, gaes, kadek, kana’, tretan, bos, ketum, cong, dan seneor.Kata Kunci: Sistem Sapaan, Bahasa Madura, Kajian SosiolinguistikAbstractThe research studies the phenomenon of language in address of Maduranese language among the Community in the Masaran Village. The main goal is to describe the forms of greeting in the speech of the Masaran Community and its development to date. It is a kind of descriptive qualitative study, with the note-taking and observation method. The data of this study is a speech of the Masaran Community both verbally and portrayed on social media (WA). Tehe result of this study shows that any forms of greeting in family real, such as, Aba/abi, Bapak, eppa’, mama’, ummi, ebok, embu’, emma’, nyaih/emba bini’, kaeh/ emba lake’, juju’, emba’, embug, eyyu, mas, kaka’, caca’, mak,), ale’, ade’, anum, om. Teh greeting in social realm, such as, cong, ke’, num, ka’, keh, nyi, pa’, ajjih. The greeting for the pronoun firts person, such as engko’, sengko’, kuleh, guleh, kauleh, abdinah. So for propernoun second person, such as, be’en, empiyan, sampiyan, ajunan, panjenengan. the pronoun third person use the original name, Pa’+ firts child’s name, and epithets. The form of greeting among teenagers in the social media, such as, ni’, gaes, kadek, kana’, tretan, bos, ketum, cong, dan seneor.Keywords: Sistem of Address, Maduranese Language, Sociolinguistic Studies
Primary adrenal anaplastic large cell lymphoma: a case report and literature review (Preprint)
Authors: Liang Xiao-Qin , Zhang Wen-Xia , Yang Yong-Qing , Wang Hui-Chun , Wang Zhuo , Feng You-Fan
Published: October 2022

UNSTRUCTURED

Involvement of the adrenal gland by anaplastic large cell lymphoma (ALCL) is infrequent. We report a 69-year-old male patient who underwent general weakness and anorexia for one year. Positron emission tomography-computed tomography (PET-CT) scan demonstrated that an exophytic mass on bilateral adrenal gland. The pathological diagnosis was considered to be ALK-negative ALCL, which was extremely rare. The treatment effect of ring CHOP-E regimen was not satisfactory, and the patient's condition improved after recevied CD30 mab combined with CHP regimen. We review previously reported cases in the literature to better characterize this rare disease. ALCL is an extremely rare adrenal gland tumor with atypical clinical and imaging manifestations, and is easily misdiagnosed. A comprehensive model of chemotherapy and radiotherapy is recommended for treatment, but the prognosis is poor.
How do nurses work in the age of Artificial intelligence:Viewpoint (Preprint)
Authors: Ye Minghui , Lu Zhongqiu , Sun Hongyu
Published: October 2022

UNSTRUCTURED

AI is undoubtedly revolutionizing medical research and patient care with various applications in several fields. Chronic disease nursing care, an important part of clinical management, has benefited much from AI in many ways. It is important to understand the principles that make it workable before using artificial intelligence, not to blindly replace all work with AI. Nurses are the main force of symptom group research, expanding from the diabetes to other chronic disease, they are mainly responsible for patients daily symptom and vital signs record. However, many AI research currently exclude nurses from the development phase and only include them in the use and feedback population. The overall design of the symptom analysis and long-term management approach cannot be done without the guidance and supervision of nurses, but currently nurses are not sufficiently involved, which may be related to the fact that nursing staff have less understanding of AI compared to other researchers and are not yet clear about the value of their role in AI. Therefore, it is very necessary to explore the role points of nurses in symptom analysis and long-term management, and to analyze the breakthrough points of nurses' work in AI in the future by drawing on the latest research in these two areas.
Definition and Truth in Social Science
Authors: Lane Jan-Erik
Published: October 2022

Language is important in social science theories. We employ a number of terms taken from ordinary speech, thus importing ambiguity and opaqueness. The remedy is to introduce explications, i.e., making stipulations about meaning. The risk involved is the analytic statement, i.e., treating sentences as true by definition or meaning.
Civil Liability of Doctors in Times of Covid-19
Authors: Barreto Lucas dos Santos , Gitahy Raquel Rosan Christino
Published: October 2022

The consumer protection code provides that physicians' responsibility is, as a rule, subjective. In view of the pandemic context experienced since 2020, the present research started from the following problem: How to understand the subjective responsibility of the doctor, highlighting the element of guilt, in times of Covid-19? In order to answer this question, the general objective was to discuss how the doctor's guilt is configured in relation to a damage caused by him in the face of a patient in times of Covid-19 and consequently the hypotheses of indemnity. carried out with a search of books, articles from qualified journals, accessible on Scielo, dissertations and theses available in the digital library of theses and dissertations. The documentary research was carried out from the analysis of decisions involving the civil liability of doctors in times of covid-19. As a result, it was observed that if the doctor, in the exercise of his professional activity, does not act with all the necessary technical means and due caution, he will commit an illicit act and may be called to indemnify. However, guilt, an essential assumption for the characterization of subjective responsibility, must be studied considering the context, as well highlighted by the three-dimensional theory of law, given that the pandemic context must be considered in order to understand the norm and value it in the social time.
Linguistic transformation and preservation of the mother tongue of Saudi Postgraduate scholarship students and their children
Authors: R Alawfi Dr. Nadyh Naser
Published: October 2022

Experiences of linguistic shift (LS) and language maintenance (LM) among Saudi postgraduates who had returned home from studying internationally were investigated. Assessment of perspectives of their first language (L1) among the learners and their children was undertaken, in addition to efforts at advocating language maintenance adopted by educational facilities, cultural and religious associations, as well as the learners themselves. Furthermore, the strengthening of language maintenance in particular fields was examined. Semi-structured interviews were carried out to discuss with and observe Saudi postgraduate students, who possessed over five years of study experience in nations where the first language is English. Evidently, no robust ties to their L1 are felt by young learners, even though their language is appreciated by postgraduate learners and they exert themselves to maintain it. Thus, a decline in L1 writing capabilities occurs, while code reversals pervade their L1. The lack of impact on L1 from language shift has been established in recent studies, while the limited duration of the issue was identified in the existing literature. Maintaining one’s L1 is affected by numerous variables, challenging common perceptions. With postgraduate learners studying and working internationally, their instruction in Arabic and English has led to a multilingual society emerging when they return home. However, isolation from and eradication of cultural norms is just one of the various detrimental outcomes of linguicide which stems from language shifts. Accordingly, this study aimed to establish the extent to which a marked change in language ability occurs among Saudi postgraduate learners when they come home.
Distribution Patterns and Consumer Preferences on Demersal Fish in North Minahasa District
Authors: Longdong Florence Verra , Ngangi Edwin L.A , R.R. Aling Djuwita
Published: October 2022

North Minahasa Regency is an area of North Sulawesi Province, which has the potential for capture fisheries that is growing significantly with the demand for raw materials for marine products, both for the consumption needs of the people of North Sulawesi in general and specifically in North Minahasa Regency itself, one of the sub-districts in North Minahasa Regency. which is the center of demersal fish capture fisheries production is Kema District. The success of marketing fish catch production is based on a well-targeted and efficient distribution pattern. This is strongly supported by interests and preferences, giving rise to a choice (preference) which one is desired. Culinary tourism in this area began to develop by showing an increasing trend. The number of restaurants or restaurants that offer grilled fish or seafood products has shown people's interest in fish consumption. The current high level of public interest in consuming fish automatically brightens the fisheries sector from upstream to downstream. The purpose of this study was to identify the marketing distribution pattern of demersal fish in North Minahasa Regency and analyze the attitudes of end consumers towards their preferences for demersal fish in North Minahasa Regency. The basic method in this research is a case study and the primary data source comes from fishermen and collectors as fish marketers, who are involved in marketing channels as well as final consumers who use the product. Respondents who are determined are producers, namely fishermen who catch Demersal fish, collectors or suppliers and final consumers in culinary centers who choose processed demersal fish products. Methods Data collection was carried out by sampling, namely: Purposive sampling for the types of producer and collector respondents, Accidental sampling for final consumers who apply their preferences to processed Demersal fish products in culinary centers located in North Minahasa district. Collecting data through interviews and direct observation as well as filling out a list of questions guided by the researcher. Primary and secondary data types, for primary data were analyzed descriptively qualitatively and descriptively quantitatively using data analysis techniques according to consumer attitude preferences. to the final consumer. The validity test was carried out on the snapper, chair, bobara, grouper, and escape variables, it was found that all the calculated r values were greater than r table, which means that all indicators in the questionnaire were declared valid with a moderately correlated to high category. The reliability test on snapper was 0.626, which means high reliability value, as well as for chariot fish the value was 0.669 , 0.721 passed and Goropa 0.600 which was categorized as sufficient for 5% and 1% error levels.
The Role of Women Living in the Region Beach Ecotourism in Increasing Family Income in East Likupang District North Minahasa District
Authors: O. Tambani Grace , Dien Christian Ronald , Mewengkang Hanny Welly
Published: October 2022

The East Likupang Subdistrict is one of the tourism destinations in North Sulawesi and even in Indonesia. East Likupang District consists of 18 villages and three of them are villages located on the coastline that have a fairly well-known coastal tourism potential, namely Surabaya Beach in Wineru Village, Pal Beach in Marinsow Village, and Pulisan Beach in Pulisan Village. The existence of these three beach tourism destinations helps the economy of the people who live in this beach tourism area. The role of women is carried out to help the husband in making a living which in the end is expected to increase family income so that family needs are met, based on this, this research wants to be carried out. The purpose of the study was to identify and analyze the form of business and activities of women's roles and analyze the amount of women's contribution to family income in the Coastal Ecotourism Area of East Likupang District. The research was carried out in Wineru Village, Marinsow Village, and Pulisan Village using the Purposive Sampling research method, the criteria for respondents were: already settled and living in the Surawaya beach ecotourism area wineru village, Pal Beach Marinsow Village, and Pulisan Beach Pulisan Village, the number of respondents in each village amounted to 20 people so that in total there were 60 respondents. The analytical tools used are Operating Profit, Net Profit, Profit Rate, Benefit Cost Ratio, Rentability, and Break Even Point. The results of the study are various forms of women's businesses living in coastal tourism areas in East Likupang District, namely selling food and soft drinks, renting out toilet services, and renting cottages for visitors where there are two roles of women carried out, namely the domestic role and the public role. The role of women is in the form of a contribution to a family income of 45% of the total family income.
Negative Sides of State Professor Council (HDGSNN) with Criminal Case at Banking University HCM City Vietnam – and Applying Malaysian Privacy Law Approach as Reference for dealing with False News of Tuoi Tre and Thanh Nien Newspapers in Vietnam
Authors: Huy Dinh Tran Ngoc , Diep Nguyen Trong , Thu Nguyen Anh , Hue Ly Thi , Hien Dinh Tran Ngoc
Published: October 2022

In this study, we highly criticize publishing fake news online of several Vietnam magazines (Thanhnien.vn and Tuoitre.vn) as it may cause misinformation and troubles, anxiety in society. Next, we show criminal cases at HDGSNN (State professor Council- fake Prof Trần Thọ Đạt), and Nguyễn Đức Trung – fake Rector at Banking University HCM city Vietnam (in hindering scientific researches of scientists), and Lê Đình Hạc – fucking guy, fake Doctor at Banking University HCMC Vietnam. We also use this case to teach social sciences students. Next, authors use Malaysian laws approach for solving FALSE NEWS OF TUOI TRE AND THANH NIEN NEWSPAPERS IN VIETNAM during period 2015-2022. Last but not least, Authors also analyze viewpoints of President Ho Chi Minh on publishing activities for educating students better.
Zen Masters in the Ly Dynasty - Tran Dynasty in Thanh Hoa
Authors: Hung Ha Dinh
Published: October 2022

Buddhism and the ideas that promote tolerance are of great significance to Vietnam's cultural history. The position and influence of Buddhism have been proven since its introduction, especially under the Ly dynasty under the Tran dynasty, an important period that was meant to shape Vietnamese cultural identity during the independence period free. Buddhism with the land of Thanh Thanh is an issue that has not been adequately evaluated by researchers due to the meager nature of documents remaining to this day. The article focuses on clarifying aspects of Buddhism's influence on various aspects of social life in the historical and cultural context of Ai Chau (Thanh land) at the time from historical documents and epitaphs. remains to this day. Gives us a full picture of a special historical-cultural period of Thanh land under the Ly-Tran dynasties.
Existence of periodic or nonnegative periodic solutions for totally nonlinear neutral differential equations with infinite delay
Authors: Guerfi Abderrahim , Ardjouni Abdelouaheb
Published: October 2022

In this work, we investigate the existence of periodic or nonnegative periodic solutions for a totally nonlinear neutral differential equation with infinite delay. In the process, we convert the given neutral differential equation into an equivalent integral equation. Then, we employ Krasnoselskiǐ-Burton’s fixed point theorem to prove the existence of periodic or nonnegative periodic solutions. Two examples are provided to illustrate the obtained results.