bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial efficacy of Doxycycline as a Photosensitizer in Photodynamic Therapy against Subgingival Plaque Bacteria
Authors: Fitria Augustina Eka , Maduratna Setiawatie Ernie , Permata Hartamto Offia Melda , Marwah Yunita
Published: December 2024

Background: Periodontitis is an inflammation that occurs in the periodontium and is caused by the host immune responses and subgingival plaque bacteria. Subgingival plaque bacteria can initiate periodontal disease because they have the potential to induce the release of proinflammatory cytokines. Mechanical debridement alone not always possible to completely remove pathogenic bacteria that cause periodontal infections due to accessibility and location. New treatments, such as photodynamic therapy, which uses lasers, can offer an alternative option. Photodynamic therapy is a non-invasive therapy that uses photons of light energy for medical purposes. The mechanism of photodynamic therapy is based on a triad consisting of a photosensitizer, a light source, and molecular oxygen. Microorganisms first absorb the photosensitizer, then are activated by light of a specific wavelength. Photosensitizer can transfer the received energy to molecular oxygen and convert oxygen into ROS, then cause the death of microorganisms by affecting their membranes, proteins, and nucleic acids. Doxycycline is widely used in periodontal therapy and is known to act as an exogenous photosensitizer. Objective: The aim of the research was to evaluate the potential of doxycycline as a photosensitizer in photodynamic therapy against subgingival plaque bacteria. Method: The research used the diffusion method to test the bacterial inhibition with 4 replications. This research was divided into 6 groups: (1) control, (2) photodynamic therapy, (3) 0,0125% doxycycline with photodynamic therapy, (4) 0,025% doxycycline with photodynamic therapy, (5) 0,05% doxycycline with photodynamic therapy, and (6) 0,1% doxycycline with photodynamic therapy. Subgingival plaque bacteria were collected from stock and put into a reaction tube that contained liquid BHIB. After that, the subgingival plaque bacteria culture was incubated for 48hours at 37ºC, and then the subgingival plaque bacteria culture was planted on Mueller Hinton agar with the spreading technique. Filter paper was inserted into each of the doxycycline concentrations and placed on the petridish that has been planted with subgingival plaque bacteria. Photodynamic therapy with a wavelength of 405nm for 30 seconds was exposed to the paper. Then, the agar plates were incubated for 48 hours at 37ºC. Result: The avarage inhibition zone of subgingival plaque bacteria was obtained in the following groups: (1) 0mm, (2) 13.375mm, (3) 14.6125mm, (4) 15.450mm, (5) 17.325mm, and (6) 19.2875mm. Conclusion: The doxycycline 0.1% concentration group that is combined with photodynamic therapy for 30 seconds has the biggest inhibition zone in the subgingival plaque bacteria.
Assessment of Quality parameters and Safety in Indigofera tinctoria L. (Avuri) Rootbark extract
Authors: Abarna B. , Saranyapriya E. , Adithya R. Sathish , Murugesan S. , Madhavan R.
Published: December 2024

Avuri (Indigofera tinctoria Linn) has widely been used for the treatment of poisonous bites, epilepsy, nervous disorders, bronchitis, dermatological disorders, and liver ailments in Indian traditional medicine. Extensive research has been made into the aerial extracts of this plant for medicine preparation. Despite being used in medicinal formulations, especially in the treatment of poisonous bites the root bark has been less studied. This study is the physiochemical and safety of methanolic extract of Avuri verpattai. Roots were excised from mature plants collected from the Hills of Palani, then the root bark was peeled and air-dried. Extraction was done in a Soxhlet apparatus using a methanolic extraction procedure. Further, the extracts were used for preliminary phytochemical, physiochemical analysis, and safety analysis like aflatoxin, pesticide residue, Microbial contamination, and heavy metals. The phytochemical analysis showed the presence of alkaloids, flavanoids, steroids, triterpenoids, coumarin, phenol, tannin, saponin, sugar and betacyanin. The physiochemical tests conducted on the root bark extract unveiled specific parameters: pH(4.73), Total ash (3.59% w/w), acid insoluble ash (0.4751% w/w), loss on drying at 105°C(3.45% w/w), water-soluble extractive (8.74%w/w), and alcohol soluble extractive (1.91% w/w). The bulk density was 0.2496g/ml, while the tapped density was determined as 0.4940g/ml for the extracts. Safety assessment conducted via aflatoxin analysis, microbial contamination, and pesticide residues, indicated the absence of such toxins in the extract. Additionally, trace amounts of heavy metals mercury and arsenic were detected at levels of 0.334 and 1.970ppm, respectively. The study reveals that the Methanolic extract of Avuri verpattai has significant quality and safety. Consequently, these parameters can serve in the study of Avuri verpattai Extract, as an important Siddha medicinal preparation.
Investigation of biological membrane permeability of nanoemulsion, nanostructured lipid carriers and lipid polymer hybrid nanocarriers based nanogel as transdermal carvedilol delivery system
Authors: Kadhim Drais Hayder , H. Ihmedee Falah , Sharaf El-Din Mohie K. , A. Naser Naser
Published: December 2024

Carvedilol was antihypertensive and antioxidant properties. It was practically water insoluble. It undergoes extensive hepatic first pass metabolism. The aim of this research to study permeability coefficient for NE, NLCs and LPHNs based nanogel through biological membrane using carvedilol as transdermal drug delivery system (TDDS). Aqueous phase titration, ultrasonic emulsion evaporation and microwave-based methods were used to prepare NE1-NE3, NLC1-NLC3 and LPHN1- LPHN3 respectively then subject to various measurements. The formulated lipid-based nanoparticles NE1-LPHN3 were employed as base to prepare lipid base nanogel G1- G9 that was compare to already prepared conventional gel of carvedilol (G). It was found colloidal features associated with the carvedilol loaded lipid-based nanoparticles NE1- LPHN3. The biomembrane permeation evaluation of G1-G9 formulations was indicated that the permeability coefficient (cm/min) of drug was significantly higher (p-value <0.05) for G1 and was significantly lower (p-value < 0.05) for conventional carvedilol gel (G). The preparation and evaluation processes were emphasized that G1-G9 suitable to deliver across biomembrane. The drug that was contained in LPHN based nanoglobules had lower ability to pass through experimental skin that gave it more ability to control drug diffusion in comparison to NE and NLCs.
Exploring Nanoherbal Tomato: Assessing its Potential as an α-Glucosidase and α-Amylase Inhibitor, Antioxidant and Metabolite Profiling using LC-HRMS
Authors: Djohan Djohan , Sihombing Bungaran , Ferdinand Sahna
Published: December 2024

Nanoherbal Tomato (NT) presents a compelling avenue for exploring its multifaceted potential in the realms of metabolic regulation and antioxidative effects. In this study, NT was characterized by its particle size (936 ± 112.4 nm) and subjected to LC-HRMS metabolite profiling, unveiling key compounds such as ellagic acid, hexadecanamide, dibenzylamin, myricetin, kaempferol, and various carotenoids. To assess its therapeutic potential, NT was evaluated for its α-glucosidase and α-amylase inhibition capabilities. NT exhibited promising α-glucosidase inhibitory activity with an IC50 value of 51.62 µg/mL, surpassing the IC50 of the standard drug acarbose (78.1 µg/mL). Similarly, in the α-amylase inhibition assay, NT demonstrated a competitive IC50 value of 62.31 μg/mL, closely aligned with that of acarbose (58.56 μg/mL). These findings underscore the potential of NT as a natural agent for metabolic control. Furthermore, the study delves into the antioxidative properties of NT. In the DPPH scavenging assay, NT exhibited significant antioxidant potential, with an IC50 value of 48.281 µg/mL. The exploration of antioxidative potential opens avenues for NT's utility in mitigating oxidative stress-related conditions and enhancing overall health. The study also encompasses the determination of total phenolic content (TPC) and total flavonoid content (TFC) in NT. Results revealed high values of TPC (300.21 ± 15.20 mg GAE/g) and TFC (20.78 ± 1.82 mg QE/g) in NT, reflecting its rich phenolic and flavonoid composition. In summary, this study comprehensively examines NT's particle size, metabolite profile, α-glucosidase and α-amylase inhibitory activities, antioxidative potential, and phenolic and flavonoid content. These findings shed light on the multifaceted properties of NT, positioning it as a promising candidate for metabolic regulation and antioxidative therapy. Further research and clinical investigations are warranted to fully harness the therapeutic potential of Nanoherbal Tomato.
The Molecular detection of blaVIM in carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex infections in Indonesia
Authors: Homenta Heriyannis , Silvana Rares Fredine Esther , Amelia Waworuntu Olivia , Fidel Matandung Lewis , Faiz Sandjaya Sulaiman , Costanty Togas Bellanty , Julyadharma Julyadharma , Susianti Hani , Santosaningsih Dewi , Noorhamdani Noorhamdani
Published: December 2024

Background: Bacteria of carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRABC) is a significant pathogen causes illnesses acquired via healthcare around the world, however little is known regarding the molecular resistant gene of A. baumannii-calcoaceticus complex bacteria resistant to carbapenem in Indonesian healthcare facilities. This study is aimed to identify the carbapenemase resistant gene of CRABC in two referral care hospitals in the islands of North Sulawesiand East Java, Indonesia. Methods: The Vitek2® system was used to identify the CRABC pathogen that were obtained from standard medical cultures, which included blood, lower respiratory tract, wound and urine samples from patients treated in the medical wards, intensive care unit (ICU), surgical wards, neonatal intensive care unit (NICU), and cardiovascular intensive care unit (CVICU) in two referral care hospitals in Manado, North Sulawesi, and Malang, East Java. Using PCR, we identified the presence of the carbapenemase resistance genes blaGES, blaVIM, blaIMP1, and blaOXA-48 carbapenemase resistance genes. Results: Seventy threeA. baumannii-calcoaceticus complex carbapenem resistance bacteria were collected. The specimens from the lower respiratory tract specimens, the isolates of the carbapenem-resistant A. baumannii-calcoaceticus complex were frequently found.In this study, we detected the blaVIM carbapenemase resistance genes from blood and sputum samples in tertiary care hospital in Malang. Conclusions: We identified the blaVIM carbapenemase resistance genes were found in the referral care hospitals in Malang, East Java, Indonesia. Awareness of the national prevention and surveillance system is isolated by the prevention and reduction of CRABC transmission.
POSTOPERATIVE PANCREATITIS IN HEPATIC RESECTIONS - ROLE OF PRINGLE'S MANEUVER
Authors:   Department of General and Operative Surgery, Medical Faculty, Medical University Sofia, Bulgaria., Todorov Radoslav , Tosheva Emilia ,   Department of General and Operative Surgery, Medical Faculty, Medical University Sofia, Bulgaria., Tocev Radko ,   Department of Obstetrician and Gynaecology, First Clinic of Gynaecology, University Hospital SBALAG "Maichin Dom" Sofia, Bulgaria., Yonkov Atanas ,   Department of General and Operative Surgery, Medical Faculty, Medical University Sofia, Bulgaria.
Published: December 2024

Background: The mechanism of postoperative pancreatitis still remains not profoundly explored in the area of liver resections. Three main mechanisms are named for the origin of pancreatitis following liver resections. The first mechanism has its foundation based on intrahepatic bile-ducts lithiasis, which leads to bile-stones or sludge migration during operation, obstructing the duodenal papilla The other mechanism elucidates haemobilia as the main factor, forming blood clots that migrate and obstruct the duodenal papilla. The Pringle maneuver is the third reason for pancreatitis, which causes blood congestion in the splanchnic area, particularly the pancreatic venous vessels.
Aim: to evaluate and define the leading mechanism of developing postoperative pancreatitis in liver resections by statistical retrospective analysis and explore the main complications following pancreatitis.
Methods: For the period from 2018 to 2023, 64 patients developed postoperative pancreatitis after liver resections. The study was conducted in a retrospective study fashion, exploring statistically the reasons and mechanisms leading to pancreatitis, comparing different factors like the type of liver resection, presence or lack of haemobilia, application of Pringle maneuver, time under warm ischemia utilizing the Pringle maneuver. Data was processed with SPSS ver 23.000
Results: Pancreatitis was found predominantly after atypical liver resections and bi-segmental resections. Haemobilia didn't prove to be a factor for pancreatitis. Warm ischemia and the time of its application proved to be one of the main factors for pancreatitis.
Conclusions: Warm ischemia and type of liver resection are the main factors leading to the development of pancreatitis.
A COMPARATIVE ANALYSIS OF ACCESS TO SPECIALIZED OUTPATIENT MEDICAL CARE IN BULGARIA AND THE USA
Authors:   Department of Health Economics, Faculty of Public Health, Medical University-Sofia, Bulgaria., Zlatanova Tihomira , Popov Nikolay ,   Department of Health Economics, Faculty of Public Health, Medical University-Sofia, Bulgaria., Zlatanova-Velikova Ralitsa ,   Department of Health policy and management, Faculty of Public Health, Medical University-Sofia, Bulgaria.
Published: December 2024

The patient's access to medical care is a fundamental component of assessing public health systems. We conducted a questionnaire-style survey in Bulgaria and the USA in order to analyze the access to specialized outpatient care and determine whether there are inequities in access present. The questionnaire was anonymous and was distributed in the March 2023 - May 2023 period via the use of the Google Forms online platform among 395 adult citizens of Bulgaria and 387 adult citizens of the USA. The results show that, according to the respondents, there are inequities present in specialized outpatient medical care (SOMC). In Bulgaria, every fifth participant (20.42%) was xamined by a specialist physician one day after acquiring a referral from the GP, and 35.74% waited over a week. In the USA, the largest portion of the respondents (42.64%) were examined by a specialist a month after and 26.43% after 2-3 months. In the context of the COVID-19 pandemic, the largest portion of respondents in Bulgaria (49.87 %) experienced access to specialist becoming harder, while the largest portion of respondents from the USA didn't experience changes in access.
Enhancing Security in IoT Networks: A Focus on Authentication and Access Control
Authors: Mohamed Ayari
Published: December 2024

This research paper addresses the escalating security concerns within the Internet of Things (IoT) by focusing on authentication and access control mechanisms. We explore various challenges unique to IoT, such as scalability and device diversity, and review both traditional and advanced security measures. The paper highlights innovative authentication techniques and access control models like RBAC and ABAC, demonstrating their effectiveness through practical case studies in sectors like healthcare and smart home technology. The main contribution is the presentation of tailored security strategies that ensure robust protection for IoT networks against current and future threats, paving the way for safer IoT implementations.
Key Research Areas and Trends in Bibliometric Analysis of Microgrids
Authors: Bessie Baakanyang Monchusi
Published: December 2024

Microgrids represent a novel breed of sustainable energy sources that have gained widespread adoption within the energy domain. This investigation employs bibliometric analysis techniques to scrutinize prior scientific publications on microgrids, utilizing quantitative and statistical methodologies to unveil distribution trends of articles across specific themes and time frames. Furthermore, the exploration pinpoints principal contributors and collaborative trends within the field. The findings of this study reveal a noteworthy surge in scholarly publications pertaining to intelligent grid frameworks, with a particular emphasis on cutting-edge technologies and multidisciplinary partnerships. Furthermore, the study highlights the adoption of blockchain technology in smart grids and the inclusion of renewable energy sources into microgrids. Moreover, this scholarly inquiry furnishes researchers and industry professionals with valuable insights into the current technological landscape and prospects for future research endeavors.
Biophysics of ACL Injuries
Authors: Kacprzak Bartłomiej , Stańczak Mikołaj , Surmacz Jakub , Hagner-Derengowska Magdalena
Published: December 2024

Anterior Cruciate Ligament (ACL) injuries rank among the most prevalent and severe types of injuries, significantly impacting both athletes and non-athletes alike. These injuries not only result in immediate physical impairment, such as intense pain, substantial swelling, and a marked loss of mobility, but also carry long-term health consequences that can alter a person’s quality of life. Chronic pain, persistent instability, and an increased risk of developing osteoarthritis are among the lasting effects that can follow an ACL injury. An in-depth understanding of the biophysics behind ACL injuries is paramount for devising effective prevention and treatment protocols. Biophysics, which combines principles from physics with biological systems, provides crucial insights into the mechanical and structural integrity of the ACL and its susceptibility to injury under various conditions. This systematic review aims to collate and synthesize the current knowledge surrounding the biophysical mechanisms that underlie ACL injuries.
Cervical Epidural Steroid Injection for Cervical Radicular Pain in a Patient with Fractured Cervical Hardware
Authors: Chu Kenzie , Chu Wesley , Valenti Kayla , Robinson Christopher L. , Kaye Alan D. , Hasoon Jamal
Published: December 2024

Cervical radicular pain following anterior cervical discectomy and fusion (ACDF) is a challenging condition, particularly in the presence of hardware complications. This case report discusses the successful use of a cervical interlaminar steroid injection to alleviate radicular pain in a patient who presented with a fractured screw following C6/7 ACDF. The patient’s symptoms, treatment plan, and outcome are reviewed, highlighting the success of an interlaminar steroid injection in managing radicular pain until the patient could receive corrective surgery.
Pengaruh Kemampuan Berpikir Kreatif terhadap Pencapaian Hasil Belajar pada Siswa Pendidikan Vokasi
Authors:   Pendidikan Teknik Mesin, Universitas Negeri Medan, Indonesia, Sinaga Ferry Indra Sakti H
Published: December 2024

Pola pembelajaran abad 21 menuntut pencapaian hasil belajar dengan menggunakan model pembelajaran yang kreatif dan inovatif sehingga dapat merangsang kemampuan berpikir kreatif dan berpikir kritis seluruh peserta didiknya. Kemampuan berpikir kreatif ini terdiri dari beberapa karakteristik yakni sensitivitas pengamatan, kelancaran berpikir, fleksibilitas berpikir, orisinalitas berpikir, kemampuan dalam mendefinisikan kembali, kemampuan menguraikan pikiran, kemampuan dalam menilai permasalahan, tingginya minat terhadap permasalahan, kepatuhan terhadap aturan yang ada, terbuka atas hal-hal baru, serta daya imajinasi yang kuat. Sementara untuk pencapaian hasil belajar diukur menggunakan Taksonomi Bloom yang menekankan pada kemampuan peserta didik dalam berpikir tingkat tinggi (high order thinking skills). Penelitian ini bertujuan untuk mengetahui pengaruh berpikir kreatif terhadap pencapaian hasil belajar siswa pendidikan vokasi. Penelitian ini menggunakan pendekatan kuantitatif deskriptif dengan mengambil responden sebanyak 51 siswa vokasi. Dari hasil penelitian didapatkan bahwa persamaan regresi untuk pengaruh kemampuan berpikir kreatif terhadap pencapaian hasil belajar adalah Y= 0,1044 X + 10,655 dengan nilai koefisien derminasi (r2) sebesar 0,41. Artinya kemampuan berpikir kreatif mempunyai hubungan yang positif terhadap hasil belajar dengan kekuatan determinasi sebesar 41% yang menunjukkan bahwa hubungan antara kemampuan berpikir kreatif dan hasil belajar cukup kuat.
The Transformation of Climate Justice: New Approaches in Environmental Ethics and Human-Nature Relations
Authors: Mercan Gamze , Varol Selçuk Zümrüt
Published: December 2024

This study aims to examine climate justice from the perspective of environmental ethics. While climate justice is often discussed in the context of international, class, and gender inequalities, the inequality between species and the connection to nature are frequently overlooked. This study seeks to propose an environmental ethics-based approach to end the climate crisis justly. The study employs literature review and theoretical analysis methods to examine environmental ethics approaches (anthropocentric, biocentric, and ecocentric) and evaluate the concept of climate justice in light of these approaches. Additionally, it explores the relationship between climate change and justice by drawing on deep ecology and justice theories. The study reveals that climate change creates significant injustices not only among human communities but also between humans and nature. It is found that low-income groups and women are more adversely affected by climate change despite being less responsible for it. Furthermore, the study emphasizes the need to redefine human-nature relationships to achieve climate justice. Climate change is not merely a matter of fair distribution but also a crisis that necessitates restructuring the human-nature relationship. Inclusive and fair approaches from an environmental ethics perspective must be developed to address this crisis. The deep ecology approach, which acknowledges the intrinsic value of nature beyond human needs, provides crucial guidance for a sustainable future. This study contributes uniquely to the literature by addressing climate justice in the context of not only human inequalities but also interspecies inequalities and recognizing nature as an ethical subject.
Analysis of The Practicality of Google Sites Web-Based Learning Media on The Skeletal System Material for Student Grade XI
Authors: Daud Firdaus , Roslan Rafida , Fatmah Hiola St. , Novia Arifin Arifah , Wahyudi Jasman Muh.
Published: December 2024

Learning media is everything teachers use to convey information to students, and it aims to provide stimulation and motivation to students so that there is an improvement in the quality of learning. This research aims to produce Google Sites web-based learning media as a learning medium on the subject of a valid and practical skeletal system for high school students. This type of research is Research & Development (R&D) research, which adapts the ADDIE model. The practicality analysis stage is carried out after the development stage, with product trials during the learning process. The subjects of the study were two biology teachers and 30 students of class XI Science 2. Collecting practicality data uses a questionnaire on the practicality of teacher and student responses. The questionnaire was filled out to see the practicality of the Google site's web, which was obtained through the responses of teachers and students. Based on data analysis, the practicality of the Google Sites web obtained an average teacher response score of 92.06% (very practical) and an average student response score of 85.06% (very practical). Based on the study results, it can be concluded that the Google site's web-based learning media on skeletal system materials meets the practicality criteria.
Challenges And Growth Of Capsicum Annum As A Potential Biofertilizer
Authors: Soni Dr. Sharmila
Published: December 2024

There are hundreds of species of hazardous pests and disease-causing micro-organisms in the area of agricultural ecosystems, but there are also hundreds of species of helpful companions of farming insects and useful microorganisms including fungal, bacterial, and viral organisms. These clever crop pests are fed by pathogenic bacteria and, like a quiet soldier, perform a crucial role in pest control. Which can be put to good use in pest control and has the potential to be a well-rounded, long-lasting, and inexpensive tool for doing so. When microorganisms are used to suppress pest populations, the process is known as microbial control. Finding and breeding more of a pest's natural enemies could improve their efficacy in biological management, therefore it's important to keep an eye out for them. An innovative method of biological management, this strategy makes use of naturally occurring microorganisms that are spread by the targeted pests. Which is accessible from people who are competent in marking and is also extremely easy to get at, basically, we are able to tackle this issue in such a way that it may be fixed. To disseminate the word about the benefits of organic farming, the researchers must maintain their emphasis on the phrase "organic" and actively participate in outreach programs.
Propuesta para determinar la relación entre la rapidez de nado y la frecuencia de brazada de un nadador en estilo libre usando un analizador de video
Authors: Guerrero Zambrano Marcos , Sanchez Alvarado Leonor , Valarezo Chamba Bryan
Published: December 2024

Contexto: El entrenamiento en estilo libre masculino presenta el desafío de comprender la relación entre la frecuencia de brazada y la rapidez de nado, un fenómeno físico influenciado por múltiples variables como la longitud de brazada, la altura, el somatotipo y fuerzas como la flotación, la resistencia del agua y la fuerza aplicada. Objetivo: Esta investigación tuvo como propuesta analizar dicha relación en un nadador de estilo libre masculino utilizando el software Tracker para realizar mediciones precisas y sistemáticas. Método: Durante el estudio, se midieron 9 veces la frecuencia de brazada en ciclos por segundo con su respectiva la rapidez de nado en metros por segundo, controlando variables adicionales para asegurar la fiabilidad de los resultados para obtener una gráfica lineal. Resultados: La grafica mostro un coeficiente de correlación , lo que evidenció una fuerte relación lineal entre las variables mencionadas. A partir de la pendiente de la gráfica se obtuvo la longitud de brazada de , con un porcentaje de incertidumbre relativo del 15,880% y un porcentaje de error de 19,760% comparado con el valor teórico destacándose la precisión en la tendencia observada pese a cierta incertidumbre. Conclusiones: El estudio confirmó una relación proporcional directa entre ambas variables, proporcionando información valiosa para optimizar los entrenamientos y subrayando la importancia de perfeccionar la metodología para reducir errores, además de considerar variables complementarias en futuras investigaciones.
Pelatihan dan Pendampingan Pemasaran Digital Pada UMKM Griya Kreatif Deyalina untuk Meningkatkan Penjualan
Authors: Hariyono Hariyono , Andrini Vera Septi , Aini Addin Zuhrotul
Published: December 2024

Latar Belakang: Pemasaran digital merupakan elemen krusial dalam strategi bisnis. Namun sejumlah besar UMKM mengalami kendala dalam mengadopsi dan mengoptimalkan teknologi digital untuk keperluan pemasaran. Fenomena ini juga dialami oleh UMKM Griya Kreatif Deyalina. Salah satu penyebabnya adalah belum optimalnya implementasi strategi pemasaran digital. Tujuan: pengabdian kepada masyarakat ini bertujuan untuk mendiskripsikan pelatihan dan pendampingan pemasaran digital Griya Kreatif Deyalina. Metode: Desain pengabdian kepada Masyarakat menggunakan tahapan desain intruksional Kemp Waktu pelaksanaan pengabdian selama 6 bulan. Subyek pengabdian adalah kelompok pemilik dan pengelola “Griya Kreatif Deliyana” di Kelurahan Werungotok, Kecamatan Nganjuk, Kabupaten Nganjuk, Jawa Timur. Hasil: hasil pengabdian kepada masyarakat yakni pelaksanaan pelatihan dan pendampingan pembuatan konten yang menarik melalui alat-alat bantu (tools) baik software atau hardware pada tanggal 20 September 2024, pelatihan dan pendampingan manajemen  DPB pada tanggal 24 September 2024, pelatihan dan pendampingan manajemen platform marketplace pada tanggal 27 September 2024. Kesimpulan: kesimpulan dari kegiatan ini yakni pelaksanaan pelatihan dan pendampingan pembuatan konten yang menarik melalui alat-alat bantu (tools) baik software atau hardware, pelatihan dan pendampingan manajemen DPB, pelatihan dan pendampingan manajemen platform marketplace terlaksana dengan lancar dan menghasilkan pengetahuan baru terkait pemasaran digital pada UMKM Griya Kreatif Deyalina.
Analisis Implikasi UU ITE Terhadap Kebebasan Berekspresi di Ruang Digital: Studi Kasus Greenpeace Indonesia
Authors: Remanu Alifah , Purwanto Calista , Fajri Nadhira , Lukman Firman
Published: December 2024

Kemajuan teknologi komunikasi dan informasi telah memperluas media penyampaian pendapat di dunia, tak terkecuali di Indonesia. penerapan UU ITE di indonesia kerap menimbulkan perdebatan karena disinyalir membatasi kebebasan berpendapat masyarakat dan organisasi di Indonesia yang aktif bermedia sosial, salah satunya kasus Greenpeace Indonesia. Penelitian ini ditujukan untuk menganalisa kasus kendala dan resiko dari UU ITE yang melibatkan organisasi Greenpeace. penelitian ini menggunakan metode kualitatif melalui analisis studi kasus serta berita artikel yang beredar di masyarakat. Hasil penelitian kami menunjukan bahwa UU ITE memang masih memiliki banyak kendala dalam pengaplikasiannya sehingga organisasi sejenis perlu lebih berhati hati dalam menyuarakan pesan sosial yang ingin disuarakan yang tentu mempengaruhi efektivitas penyampaian pesannya. Pada akhirnya, UU ITE juga berdampak pada kualitas demokrasi masyarakat Indonesia kedepannya. Penelitian ini merekomendasikan dilakukannya revisi terhadap UU ITE untuk mencegah hal-hal yang tidak diinginkan kedepannya.
Klasifikasi Pengadaan Obat Jaminan Kesehatan Nasional Melalui E-Purchasing Menggunakan Algoritma K-Nearest Neighbor
Authors: Fauzie Mohammad , Supatman
Published: December 2024

Pemenuhan stok obat berkualitas dalam jumlah cukup merupakan target yang harus dicapai dalam program Jaminan Kesehatan Nasional (JKN) yang dilaksanakan oleh fasilitas kesehatan secara elektronik. Penelitian ini bertujuan melakukan klasifikasi pengadaan obat JKN melalui E-purchasing. Data penelitian bersumber dari dashboard transaksi pada E-Katalog atau Katalog Elektronik Sektoral Kementerian Kesehatan selama periode Januari hingga Oktober tahun 2024 menggunakan algoritma K-Nearest Neighbor (K-NN). Pengujian dengan euclidean distance yaitu jarak kedekatan data latih dan data uji berdasarkan tiga atribut yaitu tingkat komponen dalam negeri, kuantitas, dan harga satuan obat. Jumlah dataset sebanyak 156 record dengan perbandingan data 80:20. Hasil penelitian menunjukkan accuracy tertinggi sebesar 98% pada nilai k=7 dan k=9 sedangkan accuracy terendah sebesar 94% pada nilai k=3. Hasil ini membuktikan bahwa algoritma K-Nearest Neighbor mampu melakukan klasifikasi obat JKN melalui E-purchasing dengan baik.
Geoelectrical Investigation of the Groundwater Potential in Eti-Osa, Lagos State, Nigeria
Authors: Gbadebo Adewole Michael , Olurin Oluwaseun Tolu , Badmus Ganiyu Olabode , Salami Sikiru
Published: December 2024

An electrical resistivity survey was conducted in Eti-Osa, Lagos State, Nigeria, to characterize the subsurface lithologic units, delineate the underlying aquifer, and assess groundwater potential. The study utilized an ABEM SAS 1000 terrameter for the data acquisition. Eight vertical electrical soundings were carried out using the Schlumberger electrode configuration. Data interpretation, both qualitative and quantitative, was presented through tables, charts, and sections. The interpreted geoelectric models revealed three to five layers with varying lithologies, including topsoil, sand, silty sand, sandy clay, silty clay, and clay. The first geoelectric layer, with resistivity values ranging from 8 Ωm to 320 Ωm, is relatively thin, with a thickness between 0.4 m and 3 m. The second layer exhibits thicknesses of 1.3 m to 15 m and resistivity variation between 1.5 Ωm to 185 Ωm. The third layer varies in thickness from 1 m to 36 m, with varying resistivity between 9 Ωm to 335 Ωm. The fourth geoelectric layer has a thickness range of 5 m to 20 m and resistivity values between 1.6 Ωm and 193 Ωm. The basement resistivity ranges from 3 Ωm to 361 Ωm. The study identified the sand layers, particularly at VES points 1, 2, 3, and 8, as the most promising for groundwater extraction. In contrast, VES points 4 and 5 are less favorable, and points 6 and 7 may yield lower-quality water. It is recommended that boreholes be drilled to depths greater than 20 meters at VES sites 1, 2, 3, and 8 for optimal water quantity and quality. However, sites 3 and 8 may be at risk of contamination due to shallower depths.
UNDERSTANDING THE ROLE OF SPORTS AND PHYSICAL ACTIVITY IN PROMOTING INCLUSION AND QUALITY OF LIFE FOR INDIVIDUALS WITH INTELLECTUAL DISABILITY
Authors: Jaiyesimi Boluwaji
Published: December 2024

Every child that is born with expectation of living and fulfilling life’s expectancy. The quality of life approach focuses on what is most important to every individual.  However, each child is born with different challenges and peculiarity in the area of intellectual capacity. The condition could be present at birth as a congenital abnormality. An individual may be physically fit with no brain or body abnormalities and yet be mentally disabled. The terms mild, moderate, severe and profound are often used to classify intellectual disability. In view of this, it has been observed that poor motor control, high physical demand, fear of accident and social exclusion could limit the involvement of persons with intellectual disability in activities related to sport or physical activity. Therefore, it is needful to achieve social inclusion and quality of life for persons with intellectual disability through sports and physical activity.
SPORT EVENT PLANNING AND EXECUTION: LEVERAGING WORKFLOW GANTT AND PROCESS FLOW CHARTS AS PROJECT MANAGEMENT TOOLS
Authors: Jaiyesimi Boluwaji , Oyelami Funmilayo H.
Published: December 2024

Effective planning and execution are critical success factors for sport events of all scales. This paper explores the application of workflow charts as a project management tool to streamline and optimize the sport event lifecycle. Workflow charts offer a visual representation of tasks, decision points, and processes, facilitating better communication, resource allocation, and risk mitigation among stakeholders. The study examines the advantages of integrating workflow charts, including the identification of bottlenecks, incorporation of contingency plans, progress monitoring, and data-driven decision-making. Additionally, the paper highlights the importance of a collaborative approach, involving diverse stakeholders and leveraging their respective expertise throughout the event planning and execution phases. Case studies were presented, demonstrating the implementation of workflow charts in the organization and logistics of a major university sports event. The findings underscore the potential of workflow charts to enhance efficiency, transparency, and accountability, ultimately contributing to the successful delivery of memorable and impactful sport event experiences. Furthermore, the paper discusses the integration of project management tools such as Gantt charts and risk management matrices, emphasizing the value of a comprehensive project management framework in the sports industry.
Heavy metal intrusion and geospatial analysis of groundwater resources in Isoko North Local Government Area, Delta State, Nigeria.
Authors: Oyem Michael , Meye J , Akpomrere R.O. , Okpo S.O.
Published: December 2024

Abstract
This study examined the spatial variation in the intrusion of heavy metals in underground water resources of Isoko North Local Government Area, Delta State, where it conducted a comparative study from ten (10) spatially distributed boreholes, for possible intrusion of the pathogen. The data that was produced were subjected to Heavy Metal Index (HMI) technique to analyse the significant contamination rate in the samples extracted from the study area (using the World Health Organisation Standard and the Nigerian Standard for Drinking Water Quality as the Control Variable). The result of the analysis showed that the undergroundwater there has slightly higher concentrations of Iron and lead than any other parameters.  Lead (Ppm) has a range of values of 0.11 to 0.18, with areas like Owhelogho (0.18), Iyede (0.18) and Ellu (0.17) having higher values than others. The range of value for Iron (Ppm) is 0.31 to 0.43, with all the areas having significant values slightly higher than the WHO and NSDWQ standard of 0.3. The study identified places where heavy metals intrusion is prevalent, also a substantial association between pollutant from host rocks and groundwater supplies. The heavy metal index evaluation revealed a class "II" grade, indicating the presence of lead and iron oxide in modest quantities, although its presence is a cause for concern for the well-being of borehole water consumers.The statistics are quite close to the next class on the indexing chart, which is "slightly affected". Any small infiltration raises the stakes to the next level.
Mondia whitei fruit extract abates cadmium chloride-induced nephrotoxicity via the suppression of oxidative stress in rats
Authors: Anadozie Scholastica Onyebuchi
Published: December 2024

Cadmium (Cd) is an industrial heavy metal that causes toxic effects to several body organs including the kidney. Medicinal plants are used in managing various diseases caused by environmental toxicants. This study aimed to evaluate the protective ability of Mondia whitei fruit extract (MWE) against nephrotoxicity induced by CdCl₂ exposure in Wistar rats. Twenty-five male Wistar rats of 90 to 130 g body weight (b.w) were used in this study. The animals were indiscriminately assigned to five groups of five animals per group. The control group were rats in group I, whereas group II to V rats were orally administered CdCl₂ (5 mg/kg body weight (b.w)) for 5 days. Simultaneously, the rats in group III to V were co-treated with 70 mg/kg b.w of silymarin, 250 and 500 mg/kg b.w of MWE, respectively. The CdCl2 significantly (p < 0.05) increased the levels of serum renal biomarkers such as urea and creatinine, total protein and albumin. Furthermore, a substantial (p < 0.05) elevation in the nitric oxide (NO) and malondialdehyde (MDA) levels, and a concomitant (p < 0.05) reduction in the kidney activities of superoxide dismutase (SOD) and glutathione transferase (GST), and the level of reduced glutathione (GSH) were observed in the CdCl2-intoxicated rats. Alterations in the kidney's histology were also noted. Nonetheless, treatment with MWE markedly returned to normal the levels of serum kidney parameters and tissue NO and MDA. In addition, the MWE significantly (p < 0.05) elevated tissue antioxidant levels and restored the kidney histology. The result of this study suggest that MWE could potentially serve as an alternative therapy in managing CdCl2-induced nephrotoxicity.
Hydrocarbon Potential Evaluation of Chad Basin, Northeastern Nigeria Using High-Resolution Aeromagnetic Data
Authors: Fajana Akindeji , Jolayemi Damilare Moses , Eluwole Akinola Bolaji , Fagbemigun Tokunbo Sanmi
Published: December 2024

A cost-effective and non-intrusive aeromagnetic geophysical technique was utilized to reduce exploration uncertainty in the Chad Basin, which is believed to have significant hydrocarbon potential despite limited exploration due to its remote and challenging terrain. By analyzing various derivatives and magnetic attributes extracted from filtered and enhanced aeromagnetic data, the study aimed to highlight potential areas for hydrocarbon generation and preservation, allowing for more focused and detailed geophysical exploration efforts. This study produced several key maps, including a total magnetic intensity map (ranging from -168.7 to 224.8 nT), a reduction to equator map (ranging from -156.8 to 207.9 nT), and depth analysis, which helped delineate the structural framework and sedimentary thicknesses within the basin. Quantitative interpretation of these maps, along with the analytic depth map (ranging from 22.1 to 5649.3 m), tilt depth map (ranging from -76.50 to 80.40), and first and second vertical derivatives maps (ranging from -0.097 to 0.086 nT/m and -0.000240 to 0.000236 nT/m, respectively), was employed to detect geological features and thick sedimentary fills sufficient to create or trap hydrocarbons. Depth estimates indicate that the shallow sources range between 22 and 230 m, while deeper sources fall between 2747 and 6000 m, suggesting sufficient sedimentary fill for hydrocarbon generation. The basin is characterized by large sedimentary deposits that are bounded by structural features such as folds, faults, and fractures. The northern part of the basin, trending towards the northwest, eastern edge, and parts of the south, showed active structural features, including anticlines, synclines, and fractures, which are essential for petroleum trapping. These findings, coupled with the identified thicknesses and favorable structural disposition, suggest that the Chad Basin holds high potential for hydrocarbon accumulation, making it a prospective region for further exploration with more detailed geophysical methods.
Urine Proteomics in Schistosoma haematobium-induced Bladder Cancer
Authors: Aminu Salim , Obajuluwa Olukayode Adejoke , Madara Adamu Alhaji , Okiki  Abimbola Pius
Published: December 2024

Schistosomiasis, or Bilharziasis, is a neglected tropical disease caused by Schistosoma parasites, which significantly impacts public health, particularly in Africa. Schistosoma haematobium, the primary species responsible for urogenital schistosomiasis (UGS), is associated with severe chronic conditions, including squamous cell carcinoma (SCC) of the bladder. This review explores the pathogenesis of UGS and its link to bladder cancer, highlighting the molecular mechanisms involved. The chronic inflammation caused by S. haematobium eggs leads to tissue damage, fibrosis, and granuloma formation, creating a pre-cancerous environment. Notably, the role of the p53 pathway in UGS-associated bladder cancer is emphasized, with mutations in the TP53 gene and overexpression of p53 contributing to genetic instability and malignant transformation. Additionally, the review discusses the presence of oestrogen-like metabolites in the urine of UGS patients, which are suspected to be involved in carcinogenesis through an oestrogen-DNA adduct-mediated pathway. Mass spectrometric analysis of urine samples from UGS patients revealed specific metabolites, including 8-oxodG, a marker of oxidative DNA damage, which could serve as potential biomarkers for early detection and progression of bladder cancer. The urine proteome profiling also identified distinct molecular pathways activated in UGS-related bladder cancer, including Th2-type immune responses, oxidative stress, and inflammation. These findings underscore the need for further research into the host-parasite interactions and the development of diagnostic biomarkers for schistosome-induced carcinogenesis. Understanding these mechanisms could enhance treatment strategies and improve prevention efforts for UGS-related bladder cancer, particularly in endemic regions where the disease burden remains high.
Removal of three red dyes: acid, neutral and base from aqueous by adsorption using activated carbon and natural clay
Authors: Abderezak Guemache , Drif Mahmoud , Fares Kahoul , Louanes Hamzioui
Published: December 2024

The comparative study of the adsorption of three red dyes (phenolphthalein, Eosin B and carmine) on activated carbon and natural clay was carried out in a static régime. We used different physico-chemical techniques to know the crystalline structure of the DRX device, to do this a clear idea of the chemical bond by the FTIR analysis and finally to know the maximum absorbance λmax of the dyes it is by the method of analysis UV-Visible. The tree dyes removal percentage increases accordingly, reaching 99% for activated carbon and 98% for natural clay .The Langmuir and Freundlich adsorption models were used for descriptions of the adsorption equilibrium. The data was very well corrected with these models. Monolayer adsorption capacities were equal to 30 mgg-1 at which is in the range 5 - pH -8 in temperatures 25°C and time in rang 2 - hour - 30. Adsorption Measurements show that the adsorption process is very rapid and physical in nature. The results explain that the adsorption process is an exothermic and spontaneous physisorption and that the red color of three red dyes in three media (acid, neutral, base) does not influence the adsorption phenomenon
Comparative study and experimental validation of cutting forces in high-speed ball-end milling for AL 7075-T6 and AL 6061-T6 alloys
Authors: Mekentichi Sif Eddine , Benmohammed Brahim
Published: December 2024

This study examines the importance of precise cutting force prediction during high-speed ball-end milling of the AL 7075-T6 and AL 6061-T6 aluminum alloys, which are widely used in the aerospace and automotive industries, because to their strength and fatigue resistance. Predicting cutting forces is critical for optimizing milling conditions and creating high-quality surfaces. We have used a mechanistic model to estimate cutting forces based on experimental data. To generate the more precise predictions, the developed model takes into account tool geometry, cutting settings and material properties. We have measure the cutting forces on a CNC SOMAB DIAM 850 milling machine by using a Kistler 9257A dynamometer. We have done simulations with MATLAB software. The results reveal that the mechanistic model accurately predicts both alloys. ALU 7075-T6 produces higher cutting forces because to its increased strength. This comparative research demonstrates that the mechanistic approach is useful in forecasting cutting forces in high-speed ball-end milling of aluminum alloys, providing useful insights for improving machining operations.
Thermal and residual stress analysis of multi-pass welded stainless steel pipes using DEFLUX and FILM subroutine
Authors: Djendara Abdelhakim Amine , Benyamina Melouka , Benzaama Abdallah , Khiari Mohamed El Amine , Bencherif Mohamed
Published: December 2024

This study presents an in-depth investigation of the influence of welding parameters (welding speed and number of passes) on the residual stress distribution in AISI 304 (Z7CN18-09) austenitic stainless-steel tubes. A three-dimensional finite element modeling (FEM), developed in ABAQUS, was implemented to simulate the circumferential welding process. The DFLUX and FILM subroutines were implemented to model the double ellipsoid mobile heat source and thermal boundary conditions, respectively. Model validation was performed by comparing weld bead profiles and thermal cycles with experimental results, showing excellent correlation (deviation < 5%). The coupled thermal and mechanical analyses allowed evaluation of the spatiotemporal evolution of the temperature field for different welding speeds (80-160-240 mm/min) and the distribution of axial and circumferential residual stresses as a function of tube thickness. The numerical results demonstrate a significant influence of these parameters on the amplitude and distribution of residual stresses, with a notable reduction in maximum stresses for optimized welding speeds and better stress homogenization with multi-pass welding.