bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Konseling Kelompok Ringkas Berfokus Solusi untuk mengembangkan konsep diri akademik Siswa
Authors: Sumini Sumini , Saputra Wahyu Nanda Eka , Suardiman Siti Partini
Published: November 2020

Penelitian dilakukan untuk mengetahui efektifitas konseling kelompok ringkas berfokus solusi guna mengembangkan konsep diri akademik siswa kelas VIII SMP Negeri 3 Tanjungsari tahun ajaran 2018/2019. Menggunakan jenis penelitian Eksperimen, dengan desain pre-eksperimen, model yang digunakan adalah One-group pretest posttest design. Subjek dipilih dengan teknik Nonprobability Sampling Design menggunakan Purposive Sampling. Pemilihan subjek didapatkan 6 siswa dari kelas VIII SMP Negeri 3 Tanjungsari, yang kategori dari nilai skala konsep diri akademiknya rendah. Teknik pengumpulan daya yang digunakan adalah skala konsep diri akademik dan pedoman wawancara. Data terkumpul dalam bentuk kuantitatif (angka). Analisis secara statistik dilakukan menggunakan rumus t-test. Hasil penelitian dapat disimpulkan bahwa ada perbedaan signifikan antara tingkat konsep diri akademik siswa sebelum dan setelah diberikan perlakuan yaitu layanan konseling kelompok ringkas berfokus solusi.Â Abstract: This study aims to determine the effectiveness of solutions focused group brief counseling to develop academic self-concept of class VIII students of Tanjungsari State Junior High School 3 academic year 2018/2019. The type of research used was Experiments with the Pre-Experimental Design using the One-group pretest posttest design. Determination of the subject uses the Nonprobability Sampling Design technique using Purposive Sampling. The subjects of this study were 6 students from 8th grade of Tanjungsari State Junior High School 3, with a category of low academic self-concept scale values. The power collection techniques used are the scale of academic self-concept and interview guidelines. Data collected in quantitative form (numbers) are then analyzed statistically using the t-test formula. The results showed a significant difference between the level of academic self-concept of students before and after being given a solution-focused group counseling treatment.
Complex training: Efektifitas Latihan Dalam Meningkatkan Power Otot Pada Atlet Bola Voli Remaja
Authors: Pratama Riyan , Hidayat Arif , Makorohim M. Fransazeli
Published: November 2020

Complex training is an exercise method that combines plyometrics with strength training. This exercise is an exercise used to increase muscle power. This study aims to determine the effect of training of complex training methods towards leg muscle power and arm muscle power for adolescent volleyball athletes. The method used in this study is an experiment with a control group pretest - post test design. Subjects in this study are 23 adolescent volleyball athletes (14-17 years old) with 12 males and 11 females, who are divided into two groups of experimental groups (n = 12) and control groups (n = 11) with randomized matched pair design based on the ranking of the vertical jump ability. Instrument used in this study is vertical jump test (leg power) and the medicine ball throw test (arm power). The data analysis technique uses the paired t-test with a significance level of α = 0.05. The results show that training using a complex training method provides a good benefit in improving leg and arm muscle power. Therefore, this method is appropriate for used by adolescent volleyball athletes that have had experience of weight training in improving muscle power towards adolescent volleyball athletes
An algorithm for interpreting the clinical significance of chromosomal microduplications in undifferentiated forms of intellectual disorders
Authors: Беляева Е.О. , Назаренко Л.П. , Лебедев И.Н.
Published: November 2020

Идентификация хромосомных аномалий на субмикроскопическом уровне и установление их роли в этиологии интеллектуальных расстройств являются важной научной и практической задачей. Оценка патогенного значения менее изученного типа вариаций копийности ДНК - хромосомных микродупликаций представляет актуальный предмет для обсуждения. В исследовании предложен алгоритм интерпретации клинической значимости частичных трисомий, который является неотъемлемой составляющей в диагностике и профилактике хромосомных болезней.

The identification of chromosomal abnormalities at the submicroscopic level and the establishment of their role in the etiology of intellectual disorders are an important scientific and practical task. Evaluation of the pathogenic value of the less studied type of copy number variation - chromosomal microduplication - is an actual issue. The study proposed an algorithm for interpreting the clinical significance of partial trisomies, which is an integral component in the diagnosis and prevention of chromosomal diseases.
Pericentric inversion inv(9)(p24q32): cases presentation and comparative analysis with literature data
Authors: Румянцева Н.В. , Хурс О.М. , Наумчик И.В.
Published: November 2020

Представлены результаты анализа исходов беременностей у 4 носителей перицентрической инверсии inv(9)(p24q32) и сравнительный анализ с опубликованными случаями носителей inv(9)(p24q34.1) и inv(9)(p22q32). Показано, что патология репродукции в изученной когорте пациентов с протяженными (>50%) инверсиями хромосомы 9 в кариотипе включает спонтанные аборты (собственные наблюдения) и рождение жизнеспособного потомства с комбинированным хромосомным дисбалансом rec(9)dup(q)/del(p) (опубликованные случаи).

Republican Scientific and Practical Centre «Mother and Child», Belarus Reproduction data of 4 inv(9)(p24q32) carriers was presented. Published cases of inv(9)(p24q34.1) and inv(9)(p22q32) carriers were analyzed. Pregnancies outcomes of the patients with large (>50%) chromosome 9 inversions include a miscarriages (our cases) and live born children with combined chromosomal unbalance rec(9)dup(q)/del(p) (published data).
Interchromosomal insertion ins(5;4)(q31;q23q31): segregation ratio and pregnancy outcomes for carrier
Authors: Хурс О.М. , Румянцева Н.В. , Соловьева И.В. , Тарлецкая О.А. , Мараховская Э.И. , Зубко Ю.А. , Новикова И.В. , Венчикова Н.А.
Published: November 2020

Интерхромосомные инсерции - редкие хромосомные перестройки. Носители имеют высокий риск репродуктивных потерь и рождения потомства с хромосомным дисбалансом. Представлен семейный случай ins(5;4)(q31;q23q31). Проанализирована репродукция семьи. Показано, что среди плодов с хромосомной патологией выявляются варианты c частичной трисомией 4q23-q31. Приведены данные патоморфологического исследования абортированных плодов.

Interchromosomal insertions are rare rearrangements implying the highest reproductive risk. We report a familial case of ins(5;4)(q31;q23q31). Reproductive history was analyzed. It was shown that fetuses with partial trisomy 4q23-q31 are detected. The results of a pathomorphological study of aborted fetuses were presented.
Clinical and molecular cytogenetic characterization of two cases of inverted duplication deletion 8p
Authors: Юрченко Д.А. , Миньженкова М.Е. , Дадали Е.Л. , Шилова Н.В.
Published: November 2020

Синдром инвертированной дупликации короткого плеча хромосомы 8 со смежной терминальной делециенй (inv dup del(8p), ORPHA 96092) - редкая хромосомная аномалия (ХА) с частотой 1/10000-1/30000 живорожденных. В статье представлены клинические и молекулярно-цитогенетические характеристики двух неродственных пациентов с синдромом inv dup del(8p) и уточнены механизмы формирования хромосомного дисбаланса.

Inverted duplication deletion 8p syndrome (inv dup del(8p), ORPHA 96092) is a rare chromosomal abnormality with a frequency of 1:10,000 - 30,000 newborns. Clinical manifestations of this syndrome include mental retardation, facial anomalies, hypoplasia/agenesis of corpus callosum, scoliosis and/or kyphosis, hypotonia, congenital heart defects. The article presents the clinical and molecular cytogenetic characteristics of two patients with inv dup del (8p) syndrome and clarifies the formation mechanisms.
Correction of the embryonic karyotype at the preimplantation stage of human development
Authors: Жигалина Д.И. , Скрябин Н.А. , Канбекова О.Р. , Артюхова В.Г. , Светлаков А.В. , Лебедев И.Н.
Published: November 2020

Сравнительное молекулярное кариотипирование внеклеточной ДНК из внутриполостной жидкости бластоцисты, а также эмбриобласта и трофэктодермы позволило получить свидетельства в пользу наличия механизмов самокоррекции эмбрионального кариотипа на преимплантационном этапе развития человека.

Comparative molecular karyotyping of cell-free DNA from the blastocoele fluid of the blastocyst and the embryoblast and trophectoderm, allowed us to obtain evidence for the presence of mechanisms of self-correction of the embryonic karyotype at the preimplantation stage of human development.
The study of chromosomal abnormalities in fetuses with ultrasound markers and malformations
Authors: Киевская Ю.К. , Канивец И.В. , Пьянков Д.В.
Published: November 2020

Микроделеционные и микродупликационные синдромы выявляются примерно у 8% плодов с врожденными пороками развития (ВПР), однако диагностика патогенных CNVs в пренатальном периоде в данный момент не регламентирована и зачастую основана на технических возможностях лаборатории. Представлены результаты исследования плодов, которые имели ВПР и/или маркеры хромосомной патологии, установленные по УЗИ, методом хромосомного микроматричного анализа (ХМА). В выборке (N=1048) у 10,3% плодов были обнаружены числовые аномалии хромосом и у 7,4% плодов были выявлены патогенные хромосомные аномалии, которые невозможно выявить при стандартном кариотипировани из-за их малого размера. Результаты нашего анализа согласуются с данными литературы, демонстрирующей большую эффективность SNP-микроматриц по сравнению с классическими цитогенетическими методами.

Microdeletion and microduplication syndromes are detected in approximately 8% of fetuses with congenital malformations, however, the diagnosis of pathogenic CNVs in the prenatal period, at the moment, is unregulated and often based on the technical capabilities of the laboratory. The thesis presents the result of a study of fetuses that had congenital malformations and / or markers of chromosomal abnormalities, determined by ultrasound, by the method of chromosomal microarray analysis. Using chromosomal microarray analysis in our sample (N = 1048), numerical chromosome abnormalities were detected in 10.3% of the fetuses and pathogenic chromosome imbalance was revealed in 7.4% of the fetuses, which cannot be detected by standard karyotyping. The results of our analysis are consistent with the data of the scientific literature, which demonstrates the greater efficiency of using SNP microarrays in comparison with classical cytogenetic methods.
Sperm aneuploidy in normozoospermic men and infertile pathozoospermix patients
Authors: Мартемьянова А.И. , Штаут М.И. , Сорокина Т.М. , Опарина Н.В. , Курило Л.Ф. , Черных В.Б.
Published: November 2020

Методом FISH-анализа определена частота анеуплоидии по хромосомам 13, 18, 21, X и Y в сперматозоидах у фертильных мужчин с нормозооспермией и у мужчин с нарушенной фертильностью, связанной с патозооспермией. Частота анеуплоидии у мужчин с патозооспермией превосходит частоту встречаемости сперматозоидов с анеуплоидией среди мужчин с нормозооспермией в среднем в 2 раза. Статистически значимое различие между данными группами обнаружено по частоте дисомии по хромосомам 13 и 18 (p=0,03 и p=0,01, соответственно), нуллисомии по хромосомам 13 и 21 (p=0,02 и p=0,03, соответственно) и дисомии XY (p=0,01).

FISH-analysis of sperm aneuploidy for chromosomes 13, 18, 21, X and Y was performed fertile normozoospermic men and infertile pathozoospermic men. The frequency of aneuploidy in pathozoospermic men twice exceeds the frequency of aneuploidy among normozoospermic men. A statistically significant difference between these groups was found the frequency of dysomies 13 and 18 (p=0.03 and p=0.01, respectively), nullisomies 13 and 21 (p=0.02 and p=0.03, respectively) and XY dysomy (p=0.01).
Systemic inflammation and levels of lipopolysaccharide-binding protein and soluble cd14 receptors in a comorbidity of seasonal allergic rhinitis, essential hypertension, and obesity
Authors: Усаченко Ю.В. , Белоглазов В.А. , Гордиенко А.И.
Published: November 2020

Проблема мультиморбидных заболеваний, изменяющих клинические фенотипы болезней, увеличивающих риск неблагоприятного, взаимоотягощающего течения, предъявляющего особые требования к дифференцированной медикаментозной терапии, является одной из актуальных проблем медицины. Цель: определить уровень липополисахарид-связывающего белка и sCD14 у пациентов с коморбидностью сезонного аллергического ринита, эссенциальной артериальной гипертензии и ожирения. Материалы и методы: всего обследовано 115 пациентов с сезонным аллергическим ринитом средней степени тяжести. Все пациенты были разделены на две клинические группы по наличию или отсутствию артериальной гипертензии. Деление на подгруппы проведено по индексу массы тела. Исследование проводилось в два этапа: за 3-5 месяцев до периода поллинации (1-й этап) и в период поллинации причинно-значимых аллергенов (2-й этап). Определяли уровень hs-C-реактивного белка, уровень липополисахарид-связывающего белка и sCD14. Результаты: У пациентов с коморбидностью сезонного аллергического ринита, эссенциальной артериальной гипертензии и ожирением уровень липополисахарид-связывающего белка и sCD14 в сыворотке крови были значительно выше в период поллинации причинно-значимых аллергенов, чем у пациентов групп сравнения и контрольной группы. Выводы: Установлена функциональная взаимосвязь между обострением сезонного аллергического ринита, системным воспалением и провоспалительным ответом ЛПС связывающих систем у пациентов с мультиморбидной патологией.

Background. The issue of multimorbid diseases that change their clinical phenotype, increase the risk of an unfavorable, mutually aggravating course, which requires special differentiated drug therapy, is an actual challenge for medicine. Aim: to measure levels of lipopolysaccharide-binding protein and sCD14 in patients with a comorbidity of seasonal allergic rhinitis (SAR), essential hypertension, and obesity. Materials and methods: 115 patients with moderate SAR were evaluated. All patients were divided into two clinical groups based on the presence of arterial hypertension. Patients were subdivided into subgroups according to the body mass index. The study was performed in two stages, 3-5 months before the pollination period (stage 1) and during the pollination period (stage 2). Concentrations of hs-C-reactive protein, lipopolysaccharide-binding protein, and sCD14 were measured. Results: In patients with the comorbidity of SAR, essential arterial hypertension, and obesity, serum concentrations of lipopolysaccharide-binding protein and sCD14 were significantly higher during pollination of causal allergens than in patients of the comparison and control groups. Conclusions: The study established a functional relationship between SAR exacerbation, systemic inflammation, and the pro-inflammatory response of LPS-binding systems in patients with multimorbid pathology.
Brain plasticity
Authors: Пальцын А.А. , Свиридкина Н.Б.
Published: November 2020

Пластичность мозга - способность изменяться под действием внутренних и внешних факторов и, в качестве следствия, изменять тело. Мозг - посредник, между организмом (телом) и средой. Среда и условия жизни постоянно изменяются. Через мозг осуществляются приспособления к этим изменениям организма, направленные на сохранение жизни в изменившихся условиях. Диапазон пластических возможностей мозга иллюстрируется способностью осязания заменить зрение, или способностью когнитивных и физических нагрузок, диеты, сна существенно замедлить возрастную деградацию физического и умственного здоровья. Пластичность мозга - главное условие здоровья и долголетия. Другого «эликсира молодости» сегодня нет и, по-видимому, никогда не будет. Способ поддержания пластичности мозга - его занятость. Путь к деградации мозга - интеллектуальный и физический покой.

Plasticity of the brain is an ability to change under the influence of internal and external factors and, as a consequence, to change the body. The brain is a mediator between the organism (body) and the environment. The environment, living conditions, is continuously changing. Adaptation to these changes in the body aimed at preserving life in the changed conditions occurs via the brain. The range of plastic capabilities of the brain is illustrated by the ability of touch to replace vision or the ability of cognitive and physical exercise, diet, and sleep to slow down significantly the age-related decline of physical and mental health. Plasticity of the brain is the main condition for health and longevity. There is no other “elixir of youth” today and, apparently, will never be. A way to maintain brain plasticity is to keep it busy. The path to brain degradation is mental and physical quiescence.
Mechanisms of short-term and long-term adaptation
Authors: Панкова Н.Б.
Published: November 2020

В лекции рассмотрены общие представления об адаптации, основанные на классических работах Г. Селье, Ф.З. Меерсона, Н.А. Агаджаняна, а также особенности адаптивного ответа развивающегося организма. Рассмотрены механизмы срочной адаптации как мобилизации функциональных резервов организма. В качестве одного из механизмов долговременной адаптации представлена эпигенетическая регуляция, которая позволяет выбрать и реализовать программу экспрессии генов - в соответствии с этапом онтогенетического развития, или средовым окружением. В качестве ещё одного механизма долговременной адаптации рассмотрено воздействие на генетический материал. Приведены примеры формирования адаптивного ответа организма на физико-химические и климатогеографические стрессорные факторы. Отдельно проанализированы механизмы адаптивного ответа организма детей на факторы образовательной среды.

The lecture addresses general ideas about adaptation based on classic studies by H. Selye, F.Z. Meerson, and N.A. Agadzhanyan and features of the adaptive response in a developing body. Mobilization of the functional reserve is considered as a mechanism of short-term adaptation. Epigenetic regulation is presented as one of mechanisms for long-term adaptation, which allows selecting and implementing a gene expression program consistent with the stage of ontogenetic development or the environment. Another mechanism of long-term adaptation is influence on the genome. The lecture provides examples of adaptation to physicochemical and climatic geographical stress factors. Mechanisms of the adaptive response to factors of the educational environment in children are analyzed separately.
Variability of aseptic peritonitis rates in the RDPLF
Authors: Verger Christian , Veniez Ghislaine , Dratwa Max
Published: November 2020

Aim : Peritonitis rate in the French Language Peritoneal Dialysis Registry (RDPLF) is one episode per 32 patient-months. The purpose of the present study is to evaluate the percentage of germ-free, or aseptic, peritonitis in all centers, and also by center.Methods : a first group representing all patients treated in metropolitan France in 2017 was selected to identify the rate of peritonitis and the percentage of aseptic peritonitis. Some centers have very low rates and the percentages of aseptic peritonitis would have had little value on small numbers, so we selected a second group of patients treated between 2010 and 2017 and retained centers that had at least 20 peritonitis. The rate of aseptic peritonitis in these centers was calculated individually per center. An additional survey was also carried out at the centers to find out their conditions for collecting and culturing effluent peritoneal dialysis fluid.Results : In 2017, out of 1071 peritonitis, 17.2% had no germ identified. During the period from January 2010 to December 2017, 6068 episodes of peritonitis were reported, including 954 without any germ identified (15.7%). One hundred and one centers had more than 20 episodes of peritonitis during this period. In these centers, the percentage of aseptic peritonitis has varied from less than 6% to more than 50%. The additional survey revealed that the sampling conditions varied considerably from one center to another and sometimes they even were not known to all members of the same team.Conclusion : the peritonitis rates in France and the percentage of aseptic peritonitis are in line with international recommendations. However, there is considerable inter-center variability which would require defining the best sampling conditions and the application of good bacteriological practices. It also highlights the interest of taking into account the center effect in statistical models used in studies.
Qu’est-ce qui influence le choix de la dialyse péritonéale chez les patients ? une étude qualitative.
Authors: Senghor Abdou Simon
Published: November 2020

L’objectif de cette étude était d’identifier les facteurs qui influencent le choix de la dialyse péritonéale (DP) chez les patients insuffisants rénaux, dans un centre de dialyse en France offrant un dispositif d’éducation thérapeutique du patient (ETP) aux patients en pré-dialyse. Pour ce faire, nous avons mené trente six entretiens semi-directifs avec des patients, des médecins de l’équipe d’ETP et un cadre de santé. Nous avons également observé dix séances d’ETP afin d’explorer la nature des interactions entre les patients, leurs accompagnants et l’équipe soignante. Nos résultats révèlent que les facteurs qui poussent les patients à choisir la DP sont l’influence des proches, les préférences personnelles, l’influence des médecins, l’ETP à travers l’information transmise par les éducatrices. En plus de l’influence de ces facteurs dans la construction du choix des patients à s’orienter vers une méthode de dialyse, il pourrait être encore plus productif d’intégrer des patients ressources dans les dispositifs d’ETP grâce au partage de leur expérience de patients traités en dialyse avec les patients en pré-dialyse.

 

Cette revue est mise à disposition selon les termes de la Licence Creative Commons Attribution 4.0 International.
Long nocturnal home hemodialysis : An old therapy brought up to date
Authors: Laruelle Eric
Published: November 2020

Home hemodialysis therapy orientation is rising since 2011 in France due to technical progress in dialysis machines, with a simplified use, an ultrapure and sparing dialysate delivery. The most frequent therapy is short daily dialysis sessions with performing results in terms of water and salt balance, depuration and mainly on autonomy and flexibility. In this article, we describe the organization of an alternative therapy with long nocturnal low flow hemodialysis in a dialyzed patient since 2006 after a graft failure. We discuss the benefits of this therapy, first results, eventual barriers to this method specially the occurrence of an adverse event, security and benefit of a telemonitoring and teleassistance that we develop for this occasion.
Introduction à l’analyse de données avec le logiciel R
Authors: Della Vedova Claire
Published: November 2020

Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. Toute évaluation ou étude à partir de données biologiques ou cliniques nécessite le recours à des calculs statistiques. Si les modèles complexes relèvent du spécialiste, nombre de calculs de base, tels que moyenne, médiane, etc.. sont à la portée de tous moyennant un minimum effort. Il existe un logiciel gratuit, «R», extrèmement puissant, qu’il est facile d’installer sur tout ordinateur et qui permet les calculs les plus simples comme les plus compliqués en fonction de ses compétences.

Nous avons pensé que les lecteurs du BDD, infirmiers et infirmières comme médecins seraient intéressés à suivre une formation de base qui leur donnera l’autonomie pour des études simples ou compliquées qu’ils ou elles souhaiteraient mener. Le RDPLF se tient par ailleurs à leur disposition pour leur adresser tout fichier d’export anonymisé.

Nous débutons avec ce numéro une série d’articles rédigée par Claire Della Vedova que nous remercions vivement pour l’aide apportée.

Claire est Ingénieure en biostatistique / data analyste, Elle utilise quotidiennement le logiciel R pour analyser des données. Elle a travaillé pendant plus de 15 ans dans les domaines de l’environnement et de la santé, et a formé de nombreux étudiants et chercheurs à l’utilisation de R. Elle anime depuis novembre 2017 le blog Statistique et Logiciel R dont le but est d’aider les débutants à mieux appréhender les méthodes statistiques classiques et à utiliser le logiciel R plus efficacement, notamment au travers de tutoriels : https://statistique-et-logiciel-r.com/.

Ce premier article est réservé à l’instatallation du logiciel gratuit R.
Introduction à la data visualisation sous R, avec l’add in Esquisse
Authors: Della Vedova Claire
Published: November 2020

Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l'utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de  bases  et visualiser rapidement leur données.

Le premier article de cette série d'initiation était consacré au téléchargment et à l'installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .

Ce second article est consacré à la visualisation graphiques des données statistiques.
History of peritoneal dialysis in France
Authors: Verger Christian , Chanliau Jacques
Published: November 2020

In France the first peritoneal dialysis was performed in the mid-1940s. For a long time reserved for frail subjects in whom hemodialysis appeared more dangerous, it is considered nowadays as a technique equivalent to hemodialysis, provided its indications and contraindications are respected and associated with the respect of the patient’s free choice after objective information. In particular, there is now a consensus to recognize its interest in patients waiting for transplantation, usually in order to preserve vascular access. Over the past decades French teams have played their role nationally and internationally, very often in partnership with their European neighbors, to improve the results achieved and to improve the different modalities. Since the end of the 1980s, the evaluation of practices has been made possible thanks to the participation in a specialized peritoneal dialysis registry.This article is a general review, not exhaustive, of the role played by the main French teams who succeeded one another.
Hemodialysis in isolated areas: contribution of telemedicine and analysis of specific issues
Authors: Babinet François , Vernier Louis-Marie
Published: November 2020

Telemedicine’s application to chronic dialysis had its beginnings in 2010. The experience of a remote and isolated territory is reported with a background of six years. The number of patients treated is very low, but various practical aspects are addressed: technical IT liaison, biomedical maintenance and quality controls, monitoring the care pathway of patients with chronic renal disease (CKD), and the fundamental role of caregivers. For everyone, this is an extremely rewarding activity.
Initiation au Logiciel de statistiques R : Initiation à Rmarkdown
Authors: Della Vedova Claire
Published: November 2020

NDLR : Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l’utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de bases et visualiser rapidement leur données.

Le premier article de cette série d’initiation était consacré au téléchargment et à l’installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .

Le second article était consacré à la visualisation graphiques des données statistiques avec le package Esquisse, simple d’utilisation et nécessitant peu d’apprentissage : https://doi.org/10.25796/bdd.v2i3.21313 Le troisième article était consacré à la visualisation graphiques avec le Package ggplot2 : https://doi.org/10.25796/bdd.v2i4.52303

Ce quatrième article explique comment générer un rapport d’analyse automatiquement, et de façon dynamique, en utilisant “Rmarkdown”. Il est expliqué ce qu’est Rmarkdown, son fonctionnement, et surtout, comment faire un rapport d’analyses statistiques automatisé, en pas à pas.

Comme dans les numéros précédent un fichier exemple, tiré de la base de données du RDPLF sera utlisé.
Revue de presse club des jeunes néphrologues (CJN) : 4e trimestre 2019 de la Dialyse à Domicile
Authors: Lavainne Fredéric , Morinière Beaume Julie , Nodimar Céline , Seret Guillaume , Vrigneaud Laurence , Bataille Stanislas , Carceles Odette , Gosselin Morgane , Lanot Antoine
Published: November 2020

Introduction (NDLR)

Un groupe de néphrologues issus du Club des jeunes Néphrologues sélectionne chaque mois à tour de rôle un article de la littérature internationale en rapport avec la dialyse à domicile, Dialyse Péritonéale ou Hémodialyse à Domicile, et en propose un résumé en français et son analyse. Ces résumés sont librement téléchargeables sur le site du RDPLF à l’adresse : https://www.rdplf.org/biblio.html. A partir de décembre 2018 ceux sélectionnés au cours du trimestre par ces néphrologues sont publiés sous leur nom dans la présente rubrique du Bulletin de la Dialyse à Domicile.
Revue de presse club des jeunes néphrologues (CJN) : 2e trimestre 2020 de la Dialyse à Domicile
Authors: Lanot Antoine , Lavainne Frédéric , Morinière Beaume Julie , Nodimar Céline , Seret Guillaume , Vrigneaud Laurence , Bat Stanislas , Carceles Odette , Gosselin Morgane
Published: November 2020

Introduction (NDLR)

Un groupe de néphrologues issus du Club des jeunes Néphrologues sélectionne chaque mois à tour de rôle un article de la littérature internationale en rapport avec la dialyse à domicile, Dialyse Péritonéale ou Hémodialyse à Domicile, et en propose un résumé en français et son analyse. Ces résumés sont librement téléchargeables sur le site du RDPLF à l’adresse : https://www.rdplf.org/biblio.html. Depuis décembre 2018 ceux sélectionnés au cours du trimestre par ces néphrologues sont publiés sous leur nom dans la présente rubrique du Bulletin de la Dialyse à Domicile.
Impact of SARS-CoV-2 infection in the population on peritoneal dialysis. The Spanish experience : preliminary results.
Authors: Sanchez-Alvarez Emilio , Bajo Rubio Maria Auxiliadora , Paraíso Cuevas Vicente , López de la Manzanara Virginia , Llópez Carratala Rosario , Rodríguez Puyol Diego , Trujillo Cuéllar Hernando , Grande Villoria Jesús , Cuiña Barja Luz Maria
Published: November 2020

The recent appearance of the SARS-CoV-2 pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation, and due to their characteristics, they are especially vulnerable. We present the results of the analysis of the COVID-19 Registry of the Spanish Society of Nephrology. This online registry began operating on March 18, 2020. It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments, and outcomes. Patients were diagnosed with SARS-CoV-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs and in those who had undergone screening after contact with another patient.

As of July 18, the registry had data on 1748 patients, from all the autonomous communities. The most represented form of RRT is in-center hemodialysis (HDC), followed by transplant patients. Only 55 (4%) were on peritoneal dialysis (PD). PD patients’ symptoms are similar to those of the general population. A very high percentage (93%) required hospital admission, but none in intensive care units. The most used treatments were hydroxychloroquine, lopinavir–ritonavir, and steroids. Mortality is high and reaches 18%. Age and pneumonia were independently associated with the risk of death. We also found a beneficial effect of PD over HDC.

As conclusions, SARS-CoV-2 infection already affects a significant number of Spanish patients on RRT, mainly those on HDC. The proportion of infected patients on PD is significantly lower. Hospitalization rates are very high, and mortality is high; age and the development of pneumonia are factors associated with mortality, while those on PD had lower mortality.
Development of an application for accessing and analyzing RDPLF data
Authors: Thieurmel Benoit , Masson Martin
Published: November 2020

The collection of information in the database of a medical registry finds its first interest in the possibility for a doctor and a care team to analyze their results and to compare themselves with other teams for the purpose of sharing experience and knowledge. Since 1986, the French Language Peritoneal Dialysis Registry (RDPLF) has collected data from 45,000 patients with renal failure treated at home in French-speaking countries. A partnership has been created between the RDPLF and Datastorm (https://www.datastorm.fr), the expertise and consultancy subsidiary of the ENSAE-ENSAI Group (National Schools of Economics and Statistics) in order to develop an application that allows to carry out simple statistical queries on the RDPLF database, by means of a user-friendly WEB interface. Thus, any doctor or member of the healthcare team can evaluate, without any special statistical skills, results by region and by French-speaking country. Special access also allows any center to compare its own results with those of a reference region. The generated graphics can be used for presentations during team meetings or for work. The application is based on the R software (https://www.r-project.org) and its SHINY visualization interface (https://shiny.rstudio.com). We report on development modalities and its functionalities (based on preselected criteria: incidence rate, prevalence, survival, infection rate, distribution of treatments, nursing aspects). This article describes how both nurses and doctors can easily realize studies with the application. Its bilingual interface also opens it up to English-speaking communities and thus facilitates international communication.
Evaluation of a new rapid-diagnostic test for peritonitis in peritoneal dialysis: the PERIPLEX® device.
Authors: Durand Pierre-Yves , Verger Christian
Published: November 2020

In 2017, the British company MOLOGIC developed a new rapid-diagnostic test (PERIPLEX®) for the diagnosis of peritonitis in patients undergoing peritoneal dialysis. This single-use test is based on the detection in dialysate of two biomarkers of bacterial infection: Interleukin-6 (IL-6) and matrix metalloproteinase-8 (MMP-8). The test was evaluated in a prospective multicenter study including 10 centers from the RDPLF (French Language Peritoneal Dialysis Registry). A total of 184 tests were performed; 86 tests were negative and 98 were positive. 85 peritonitis were confirmed. There were no false-negatives, and 13 false-positives. Of the 13 false-positives, 7 of them were for sepsis without peritonitis, or peritoneal inflammation. The performance of the test is considered excellent: sensitivity 100%, specificity 86.9%, positive predictive value 86.7%, negative predictive value 100%. In this study, a negative test can formally rule out the diagnosis of peritonitis.
Ultrasound Luminescence Chemical Imaging: A Tool for Detection of Implant Infection via Monitoring of pH Changes at Implant Surface
Authors: Bhattacharya Sriparna , Schober Gretchen , Uzair Unaiza , Reel Morgan , Behlow Herbert , Vigjna Abbaraju LSSN , Rao Apparao M. , Anker Jeffrey
Published: November 2020

Using ultrasound luminescent chemical imaging (ULCI) technique we imaged changes in the luminescence spectra of the ultrasound luminescent film modulated by a pH sensitive dye coating in different pH environments through a light scattering media. Our results show that high resolution images can be obtained through scattering media, and that the ultrasound luminescent film could be modulated by the pH sensitive dye.
Silica Sol-Gel Microbead Encapsulation as a Novel Delivery Method for Symbiotic Microbes
Authors: Elissiry Luke , Sun Jingwen , Hirsch Ann M. , Liu Chong
Published: November 2020

Synthetic fertilizer is responsible for the greatly increased crop yields that have enabled worldwide industrialization. However, the production and use of such fertilizers are environmentally unfriendly and unsustainable; synthetic fertilizers are produced via non-renewable resources and fertilizer runoff causes groundwater contamination and eutrophication. A promising alternative to synthetic fertilizer is bacterial inoculation. In this process, a symbiotic relationship is formed between a crop and bacteria species that can fix nitrogen, solubilize phosphorus, and stimulate plant hormone production. The bacteria carrier developed here aims to maintain bacteria viability while in storage, protect bacteria while encapsulated, and provide a sustained and controllable bacterial release. This novel bacterial delivery method utilizes inorganic nanomaterials, silica microbeads, to encapsulate symbiotic bacteria. These microbeads, which were produced with aqueous, non-toxic precursors, are sprayed directly onto crop seeds and solidify on the seeds as a resilient silica matrix. The bacterial release from the carrier was found by submerging coated seeds in solution to simulate degradation in soil environments, measuring the number of bacteria released by the plate count technique, and comparing the carrier to seeds coated only in bacteria. The carrier’s effectiveness to enhance plant growth was determined through greenhouse plant assays with alfalfa (Medicago sativa) plants and the nitrogen-fixing Sinorhizobium meliloti Rm1021 strain. When compared to bacteria-only inoculation, the silica microbead carrier exhibited significantly (P < 0.05) increased holding capacity of viable bacteria and increased plant growth by a similar amount, demonstrating the capability of inorganic nanomaterials for microbial delivery. The carrier presented in this work has potential applications for commercial agriculture and presents an opportunity to further pursue more sustainable agricultural practices.
Atomically Dispersed Iridium on MgO(111) Nanosheets Catalyze Benzene-Ethylene Coupling towards Styrene
Authors: Liu Pengxin , huang xing , Mance Deni , Copéret Christophe
Published: November 2020

Single atom catalysis has been recently recognized as an efficient utilization of metals in heterogeneous catalysis with the possibility to engender unusual reactivity. Yet, despite the observation of single atoms, controlling the uniformity in the coordination structures of supported species and understanding the structure-property relationships remains a grand challenge due to the surface structural complexity of the supports. Here, we combined the use of single-crystalline MgO(111) 2D nanosheets with surface organometallic chemistry to generate highly dispersed Ir(III) sites. The MgO(111) surfaces enable the formation of isolated Ir(III) single-sites stabilized by three 3-coordinated surface -O(H) anions at low loading (0.1 %wt) as well as Ir pairs and trimers at higher loading (1 %wt). These materials show unique catalytic properties and enable the coupling of benzene and ethylene into styrene, in contrast to the expected ethylbenzene, formed with the corresponding Ir-based homogeneous catalysts or with atomically dispersed Ir on MgO nanoparticles.
Pelvic schwannoma
Authors: Sinchikhin Sergei P. , Magakyan Sarkis G. , Magakyan Oganes G.
Published: November 2020

Relevance.A neoplasm originated from the myelonic sheath of the nerve trunk is called neurinoma or neurilemmoma, neurinoma, schwannoglioma, schwannoma. This tumor can cause compression and dysfunction of adjacent tissues and organs. The most common are the auditory nerve neurinomas (1 case per 100 000 population per year), the brain and spinal cord neurinomas are rare. In the world literature, there is no information on the occurrences of this tumor in the pelvic region.

Description.Presented below is a clinical observation of a 30-year-old patient who was scheduled for myomectomy. During laparoscopy, an unusual tumor of the small pelvis was found and radically removed. A morphological study allowed to identify the remote neoplasm as a neuroma.

Conclusion.The presented practical case shows that any tumor can hide under a clinical mask of another disease. The qualification of the doctor performing laparoscopic myomectomy should be sufficient to carry out, if necessary, another surgical volume.
Desafíos educativos que enfrenta el Colegio Nacional de Educación Profesional Técnica ante la pandemia sanitaria Covid-19
Authors: Gervacio Jiménez Herlinda , Castillo Elías Benjamín
Published: November 2020

El objetivo del estudio fue indagar las estrategias didácticas y desafíos emergentes que implementó el Colegio Nacional de Educación Profesional Técnica ante la pandemia sanitaria de Covid-19. Se utilizó una metodología cualitativa de análisis de contenido y observación participante para recolección de datos. Se revisaron conversatorios a través de seminarios web y documentos emitidos por el Colegio, los cuales, contemplaban lineamientos y estrategias a seguir para dar continuidad a la educación virtual en el marco de la contingencia. Los resultados de los seminarios donde participaron doce estados de la República Mexicana, mostraron con claridad y precisión las acciones y estrategias a seguir, afirmando que los estudiantes han respondido favorablemente a las estrategias implementadas para la realización de sus actividades escolares, pero también existe un número importante que han tenido  dificultades para cumplir con estas tareas, lo cual ha hecho evidente la desigualdad socioeconómica de los estudiantes de este subsistema. Esta experiencia lleva a nuevos retos en la  reestructuración  del currículo y revisión profunda de las carreras técnicas que se imparten en el Colegio, acorde a los nuevos tiempos y las nuevas problemáticas socioambientales y sanitarias.
Modelo Centinela: punta de lanza para la construccion de un marco informativo sobre el Covid-19
Authors: Benassini Félix María Claudia
Published: November 2020

Este artículo busca mostrar el proceso de construcción de un encuadre sobre el Modelo Centinela en tres periódicos de la Ciudad de México. Hace una revisión de los postulados de la teoría del encuadre, llevados de la sociología interaccionista al estudio de la información periodística. Lleva a cabo un análisis del discurso para ver determinar el proceso de construcción del marco "Modelo Centinela". Las conclusiones se orientan a explicar las razones de su apego en la prensa y los consecuentes problemas en la construcción de un marco alternativo para explicar el avance del Covid-19 en Mexico.
Autorregulación ante el COVID-19
Authors: Arce Valdez José , Delgadillo Guzmán Leonor Guadalupe
Published: November 2020

Se realizó la exploración de la autorreacción, autojuicio y autoobservación como componentes de la autorregulación de la conducta asociada a las medidas de salud ante el COVID-19. La investigación se enmarca en una propuesta sociocognitiva bajo un enfoque cuantitativo. Por medio de un cuestionario confiable y diseñado exprofeso para la investigación, se obtuvieron datos de una muestra por conveniencia compuesta por 220 habitantes del Valle de Toluca, quienes manifestaron la adopción, dificultad y relevancia que tienen las medidas de salud ante la pandemia. Los hallazgos muestran que mantenerse en casa, evitar frotarse los ojos y la cara, representan las acciones con mayor conflicto para ser reproducidas y valoradas por los participantes. La investigación se suma a los estudios exploratorios en la materia y, en contraste con aquellos que discuten los efectos del confinamiento, se aportan conocimientos desde la perspectiva de la responsabilidad individual ante la pandemia.
Synthesis, characterization and antibacterial studies of copper sulphide nanoparticles by chemical precipation methodSynthesis, characterization and antibacterial studies of copper sulphide nanoparticles by chemical precipation method
Authors: Gowthami R  , Nivetha K P
Published: November 2020

In this present study the non toxic CuS nanoparticles was synthesized by the reaction of copper acetate, thiourea along with the precipitating agent NaoH under chemical precipitation method. The final product CuS nanomaterial was dried at room temperature for better growth of nanoparticles. The size and growth of the crystal depends on the temperature also on the addition of reagent. The resultant nanocrystal were characterized using various techniques like X ray diffraction reveals the particle size, Scanning electron microscope determines the morphology of crystal, Energy dispersive X ray spectroscopy investigate the elemental composition of nanoparticles, U-Visible spectroscopy examine the presence of metallic ion, Fourier transform infrared spectroscopy inspect the existence of functional group. The antibacterial activity of hexagonal structured copper sulphide nanomaterials against gram positive and gram negative bacteria were also analyzed for their wide applications.
Predicting the characteristics of copper oxide nanoparticles using Nyctanthes arbor-tristis flower extract via antibacterial study
Authors: Jothi M  , Aparna Dhevi S
Published: November 2020

Copper oxide (CuO) is an inorganic compound with monoclinic crystal structure. CuO nano particles attracted considerable attention due to its numerous applications in the field of optical, catalytic, mechanical, organic dye degeneration, biomedicine, pharmaceutics,cosmetics and different medical purposes. In the present study, copper oxide nanoparticles have been prepared by biological method using the flower extracts of Nyctanthes arbortristis as a reducing agent. The resulting samples were characterized using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Energy Dispersive analysis of X-rays (EDX), UV-Visible Spectroscopy (UV) and Antibacterial activity. From XRD studies, the average crystalline size of the obtained sample was calculated by Debye-Scherrer formula and it was found to be 33.13 nm. The band gap energy of the synthesized nano particle was estimated from UV studies and its value is 1.19 eV. The morphological characteristics were absorbed by SEM studies. The EDX and FTIR studies confirm the presence of Copper Oxide nano particles.The antibacterial activity of CuO-nano particles on selected bacteria was done using agar diffusion method.