bluuebunny/crossref_metadata_2025 huggingface dataset:
Viperin is an important host restriction factor in control of Zika virus infection
Authors: Van der Hoek Kylie H. , Eyre Nicholas S. , Shue Byron , Khantisitthiporn Onruedee , Glab-Ampi Kittirat , Carr Jillian M. , Gartner Matthew J. , Jolly Lachlan A. , Thomas Paul Q. , Adikusuma Fatwa , Jankovic-Karasoulos Tanja , Roberts Claire T. , Helbig Karla J. , Beard Michael R.
Published: June 2017

Zika virus (ZIKV) infection has emerged as a global health threat and infection of pregnant women causes intrauterine growth restriction, spontaneous abortion and microcephaly in newborns. Here we show using biologically relevant cells of neural and placental origin that following ZIKV infection, there is attenuation of the cellular innate response characterised by reduced expression of IFN-β and associated interferon stimulated genes (ISGs). One such ISG is viperin that has well documented antiviral activity against a wide range of viruses. Expression of viperin in cultured cells resulted in significant impairment of ZIKV replication, while MEFs derived from CRISPR/Cas9 derived viperin−/− mice replicated ZIKV to higher titers compared to their WT counterparts. These results suggest that ZIKV can attenuate ISG expression to avoid the cellular antiviral innate response, thus allowing the virus to replicate unchecked. Moreover, we have identified that the ISG viperin has significant anti-ZIKV activity. Further understanding of how ZIKV perturbs the ISG response and the molecular mechanisms utilised by viperin to suppress ZIKV replication will aid in our understanding of ZIKV biology, pathogenesis and possible design of novel antiviral strategies.
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target
Authors: Marangoni Roberta G. , Masui Yuri , Fang Feng , Korman Benjamin , Lord Gabriel , Lee Junghwa , Lakota Katja , Wei Jun , Scherer Philipp E. , Otvos Laszlo , Yamauchi Toshimasa , Kubota Naoto , Kadowaki Takashi , Asano Yoshihide , Sato Shinichi , Tourtellotte Warren G. , Varga John
Published: June 2017

Skin fibrosis in systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and reduced levels of circulating adiponectin. Since adiponectin has potent regulatory effects on fibroblasts, we sought to assess adiponectin signaling in SSc skin biopsies, and evaluate fibrosis in mice with adiponectin gain- and loss-of-function mutations. Furthermore, we investigated the effects and mechanism of action of agonist peptides targeting adiponectin receptors in vitro and in vivo. We found that adiponectin pathway activity was significantly reduced in a subset of SSc skin biopsies. Mice lacking adiponectin mounted an exaggerated dermal fibrotic response, while transgenic mice with constitutively elevated adiponectin showed selective dWAT expansion and protection from skin and peritoneal fibrosis. Adiponectin receptor agonists abrogated ex vivo fibrotic responses in explanted normal and SSc fibroblasts and in 3D human skin equivalents, in part by attenuating focal adhesion complex assembly, and prevented and reversed experimentally-induced organ fibrosis in mice. These results implicate aberrant adiponectin pathway activity in skin fibrosis, identifying a novel function for this pleiotropic adipokine in regulation of tissue remodeling. Restoring adiponectin signaling in SSc patients therefore might represent an innovative pharmacological strategy for intractable organ fibrosis.
Diagnostic Performance of Contrast Enhanced Pulmonary Computed Tomography Angiography for the Detection of Angioinvasive Pulmonary Aspergillosis in Immunocompromised Patients
Authors: Henzler C. , Henzler T. , Buchheidt D. , Nance John W. , Weis C. A. , Vogelmann R. , Benck U. , Viergutz T. , Becher T. , Boch T. , Klein S. A. , Heidenreich D. , Pilz L. , Meyer M. , Deckert P. M. , Hofmann W.-K. , Schoenberg S. O. , Reinwald M.
Published: June 2017

Invasive pulmonary aspergillosis (IPA) is one of the major complications in immunocompromised patients. The mainstay of diagnostic imaging is non-enhanced chest-computed-tomography (CT), for which various non-specific signs for IPA have been described. However, contrast-enhanced CT pulmonary angiography (CTPA) has shown promising results, as the vessel occlusion sign (VOS) seems to be more sensitive and specific for IPA in hematologic patients. The aim of this study was to evaluate the diagnostic accuracy of CTPA in a larger cohort including non-hematologic immunocompromised patients. CTPA studies of 78 consecutive immunocompromised patients with proven/probable IPA were analyzed. 45 immunocompromised patients without IPA served as a control group. Diagnostic performance of CTPA-detected VOS and of radiological signs that do not require contrast-media were analyzed. Of 12 evaluable radiological signs, five were found to be significantly associated with IPA. The VOS showed the highest diagnostic performance with a sensitivity of 0.94, specificity of 0.71 and a diagnostic odds-ratio of 36.8. Regression analysis revealed the two strongest independent radiological predictors for IPA to be the VOS and the halo sign. The VOS is highly suggestive for IPA in immunocompromised patients in general. Thus, contrast-enhanced CTPA superior over non-contrast_enhanced chest-CT in patients with suspected IPA.
Natural and induced loss of function mutations in SlMBP21 MADS-box gene led to jointless-2 phenotype in tomato
Authors: Roldan Maria Victoria Gomez , Périlleux Claire , Morin Halima , Huerga-Fernandez Samuel , Latrasse David , Benhamed Moussa , Bendahmane Abdelhafid
Published: June 2017

Abscission is the mechanism by which plants disconnect unfertilized flowers, ripe fruits, senescent or diseased organs from the plant. In tomato, pedicel abscission is an important agronomic factor that controls yield and post-harvest fruit quality. Two non-allelic mutations, jointless (j) and jointless-2 (j-2), controlling pedicel abscission zone formation have been documented but only j-2 has been extensively used in breeding. J was shown to encode a MADS-box protein. Using a combination of physical mapping and gene expression analysis we identified a positional candidate, Solyc12g038510, associated with j-2 phenotype. Targeted knockout of Solyc12g038510, using CRISPR/Cas9 system, validated our hypothesis. Solyc12g038510 encodes the MADS-box protein SlMBP21. Molecular analysis of j-2 natural variation revealed two independent loss-of-function mutants. The first results of an insertion of a Rider retrotransposable element. The second results of a stop codon mutation that leads to a truncated protein form. To bring new insights into the role of J and J-2 in abscission zone formation, we phenotyped the single and the double mutants and the engineered alleles. We showed that J is epistatic to J-2 and that the branched inflorescences and the leafy sepals observed in accessions harboring j-2 alleles are likely the consequences of linkage drags.
Multiscale studies on the nonlinear vibration of delaminated composite laminates–global vibration mode with micro buckles on the interfaces
Authors: Xue Jianghong , Xia Fei , Ye Jun , Zhang Jianwen , Chen Shuhua , Xiong Ying , Tan Zuyuan , Liu Renhuai , Yuan Hong
Published: June 2017

This paper presents a multiscale approach to study the nonlinear vibration of fiber reinforced composite laminates containing an embedded, through-width delamination dividing the laminate into four sub-laminates. The equations of motion are established from macroscopic nonlinear mechanics for plates and shells and micro-mechanics of composite material to allow for the influences of large amplitude, membrane stretching in the neutral plane, and the interactions of the sublaminates. Analytical solutions obtained in this paper reveal that the interaction penalty at the interfaces plays a coupling effect between sublaminates, which eventually alters the vibration characters of the four-sublaminate lamina in macroscopic and microscopic mechanism. From a macro perspective, sub-laminates above and below the delamination vibrate in exactly the same mode in spite of their different stiffness and the four-sublaminate lamina has a consistent global vibration mode. In accompanying with the macro vibration, micro buckles occur on the interfaces of the delamination with amplitude about 10−3 times of that of the global mode. It is found that the vibration frequency is an eigenvalue of the delaminated lamina determined only by the geometry of the delamination. Authentication of the multiscale study is fulfilled by comparing the analytical solutions with the FEA results.
Complete genome sequence of the cellulose-producing strain Komagataeibacter nataicola RZS01
Authors: Zhang Heng , Xu Xuran , Chen Xiao , Yuan Fanshu , Sun Bianjing , Xu Yunhua , Yang Jiazhi , Sun Dongping
Published: June 2017

Komagataeibacter nataicola is an acetic acid bacterium (AAB) that can produce abundant bacterial cellulose and tolerate high concentrations of acetic acid. To globally understand its fermentation characteristics, we present a high-quality complete genome sequence of K. nataicola RZS01. The genome consists of a 3,485,191-bp chromosome and 6 plasmids, which encode 3,514 proteins and bear three cellulose synthase operons. Phylogenetic analysis at the genome level provides convincing evidence of the evolutionary position of K. nataicola with respect to related taxa. Genomic comparisons with other AAB revealed that RZS01 shares 36.1%~75.1% of sequence similarity with other AAB. The sequence data was also used for metabolic analysis of biotechnological substrates. Analysis of the resistance to acetic acid at the genomic level indicated a synergistic mechanism responsible for acetic acid tolerance. The genomic data provide a viable platform that can be used to understand and manipulate the phenotype of K. nataicola RZS01 to further improve bacterial cellulose production.
Proteomic shifts in multi-species oral biofilms caused by Anaeroglobus geminatus
Authors: Bao Kai , Bostanci Nagihan , Thurnheer Thomas , Belibasakis Georgios N.
Published: June 2017

Anaeroglobus geminatus is a relatively newly discovered putative pathogen, with a potential role in the microbial shift associated with periodontitis, a disease that causes inflammatory destruction of the periodontal tissues, and eventually tooth loss. This study aimed to introduce A. geminatus into a polymicrobial biofilm model of relevance to periodontitis, and monitor the proteomic responses exerted to the rest of the biofilm community. A. geminatus was grown together with another 10-species in a well-established “subgingival” in vitro biofilm model. Its effects on the other species were quantitatively evaluated by qPCR and label-free proteomics. A. geminatus caused a significant increase in P. intermedia numbers, but not the other species in the biofilm. Whole cell proteome profiling of the biofilms by LC-MS/MS identified a total of 3213 proteins. Label-free quantitative proteomics revealed that 187 proteins belonging to the other 10 species were differentially abundant when A. geminatus was present in the biofilm. The species with most up-regulated and down-regulated proteins were P. intermedia and S. oralis, respectively. Regulated proteins were of primarily of ribosomal origin, and other affected categories involved proteolysis, carbon metabolism and iron transport. In conclusion, A. geminatus can be successfully grown in a polymicrobial biofilm community, causing quantitative proteomic shifts commensurate with increased virulence properties.
Automatic Detection of Galaxy Type From Datasets of Galaxies Image Based on Image Retrieval Approach
Authors: Abd El Aziz Mohamed , Selim I. M. , Xiong Shengwu
Published: June 2017

This paper presents a new approach for the automatic detection of galaxy morphology from datasets based on an image-retrieval approach. Currently, there are several classification methods proposed to detect galaxy types within an image. However, in some situations, the aim is not only to determine the type of galaxy within the queried image, but also to determine the most similar images for query image. Therefore, this paper proposes an image-retrieval method to detect the type of galaxies within an image and return with the most similar image. The proposed method consists of two stages, in the first stage, a set of features is extracted based on shape, color and texture descriptors, then a binary sine cosine algorithm selects the most relevant features. In the second stage, the similarity between the features of the queried galaxy image and the features of other galaxy images is computed. Our experiments were performed using the EFIGI catalogue, which contains about 5000 galaxies images with different types (edge-on spiral, spiral, elliptical and irregular). We demonstrate that our proposed approach has better performance compared with the particle swarm optimization (PSO) and genetic algorithm (GA) methods.
Effect of boron deficiency on anatomical structure and chemical composition of petioles and photosynthesis of leaves in cotton (Gossypium hirsutum L.)
Authors: Li Mingfeng , Zhao Zhuqing , Zhang Zhihua , Zhang Wei , Zhou Jun , Xu Fangsen , Liu Xinwei
Published: June 2017

The main symptom of boron (B) deficiency in cotton is the formation of brown rings on leaf petioles. The objective of the present study was to determine the changes in the anatomical structure and chemical composition of petioles and photosynthesis of leaves in cotton under B deficiency. Compared to the control, B deficiency treatment resulted in large increases in the number of petioles with brown rings per plant (160.0%) and the number of rings on the petiole per functional leaf (711.1%) in cotton seedlings. The relative absorbance intensity in the fingerprint region of polysaccharide structure was decreased in petiole rings under B deficiency, while lignin contents were increased. Cotton plants mitigated the impairment of transport function in cotton petioles by increasing the areas of vascular bundles, phloem, xylem, and phloem fiber. Moreover, the stomatal conductance, photosynthetic rate, and transpiration rate in leaves were significantly decreased under B deficiency, thus impeding photosynthesis in cotton plants. Therefore, B deficiency reduces transport function in petioles and photosynthesis in leaves, and leads to the formation of noticeable brown rings on petioles of cotton seedlings.
Near-Zero-Power Temperature Sensing via Tunneling Currents Through Complementary Metal-Oxide-Semiconductor Transistors
Authors: Wang Hui , Mercier Patrick P.
Published: June 2017

Temperature sensors are routinely found in devices used to monitor the environment, the human body, industrial equipment, and beyond. In many such applications, the energy available from batteries or the power available from energy harvesters is extremely limited due to limited available volume, and thus the power consumption of sensing should be minimized in order to maximize operational lifetime. Here we present a new method to transduce and digitize temperature at very low power levels. Specifically, two pA current references are generated via small tunneling-current metal-oxide-semiconductor field effect transistors (MOSFETs) that are independent and proportional to temperature, respectively, which are then used to charge digitally-controllable banks of metal-insulator-metal (MIM) capacitors that, via a discrete-time feedback loop that equalizes charging time, digitize temperature directly. The proposed temperature sensor was integrated into a silicon microchip and occupied 0.15 mm2 of area. Four tested microchips were measured to consume only 113 pW with a resolution of 0.21 °C and an inaccuracy of ±1.65 °C, which represents a 628× reduction in power compared to prior-art without a significant reduction in performance.
Co-fermentation using Recombinant Saccharomyces cerevisiae Yeast Strains Hyper-secreting Different Cellulases for the Production of Cellulosic Bioethanol
Authors: Lee Cho-Ryong , Sung Bong Hyun , Lim Kwang-Mook , Kim Mi-Jin , Sohn Min Jeong , Bae Jung-Hoon , Sohn Jung-Hoon
Published: June 2017

To realize the economical production of ethanol and other bio-based chemicals from lignocellulosic biomass by consolidated bioprocessing (CBP), various cellulases from different sources were tested to improve the level of cellulase secretion in the yeast Saccharomyces cerevisiae by screening an optimal translational fusion partner (TFP) as both a secretion signal and fusion partner. Among them, four indispensable cellulases for cellulose hydrolysis, including Chaetomium thermophilum cellobiohydrolase (CtCBH1), Chrysosporium lucknowense cellobiohydrolase (ClCBH2), Trichoderma reesei endoglucanase (TrEGL2), and Saccharomycopsis fibuligera β-glucosidase (SfBGL1), were identified to be highly secreted in active form in yeast. Despite variability in the enzyme levels produced, each recombinant yeast could secrete approximately 0.6–2.0 g/L of cellulases into the fermentation broth. The synergistic effect of the mixed culture of the four strains expressing the essential cellulases with the insoluble substrate Avicel and several types of cellulosic biomass was demonstrated to be effective. Co-fermentation of these yeast strains produced approximately 14 g/L ethanol from the pre-treated rice straw containing 35 g/L glucan with 3-fold higher productivity than that of wild type yeast using a reduced amount of commercial cellulases. This process will contribute to the cost-effective production of bioenergy such as bioethanol and biochemicals from cellulosic biomass.
Territoriality ensures paternity in a solitary carnivore mammal
Authors: Palomares Francisco , Lucena-Pérez María , López-Bao José Vicente , Godoy José Antonio
Published: June 2017

In solitary carnivorous mammals, territoriality is assumed to benefit male fitness by ensuring the exclusivity of matings within territories via mate guarding and female defence. However, this hypothesis remains empirically untested. Here, we examined this hypothesis for solitary territorial carnivores using the Iberian lynx (Lynx pardinus) as a case study. We expected that territorial males sire all litters born within their territories, translating into the absence of multi-paternity cases within the same litter. We analysed parentage in 43 kittens, belonging to 20 different litters. For 42 kittens, a father could be assigned using microsatellites and always coincided with the individual holding the territory. For 16 kittens from 10 litters for which we also had information on SNPs, paternity assignments coincided with microsatellites, except for a litter (two kittens) from the same litter for which a different male was assigned, but the territorial male could not be excluded. Our results indicated that multi-paternity in the Iberian lynx must be a rare event, and that territorial males sire all litters born from the females with which they share territories. We propose that both the low number of mature individuals in the lynx population and the fact that female oestrus is induced by male presence may explain results.
Enhanced thermoelectric properties of AgSbTe2 obtained by controlling heterophases with Ce doping
Authors: Lee Jae Ki , Oh Min-Wook , Ryu Byungki , Lee Ji Eun , Kim Bong-Seo , Min Bok-Ki , Joo Sung-Jae , Lee Hee-Woong , Park Su-Dong
Published: June 2017

We report the enhanced thermoelectric properties of Ce-doped AgSbTe2 (AgSb1−xCexTe2) compounds. As the Ce contents increased, the proportion of heterophase Ag2Te in the AgSbTe2 gradually decreased, along with the size of the crystals. The electrical resistivity and Seebeck coefficient were dramatically affected by Ce doping and the lattice thermal conductivity was reduced. The presence of nanostructured Ag2Te heterophases resulted in a greatly enhanced dimensionless figure of merit, ZT of 1.5 at 673 K. These findings highlight the importance of the heterophase and doping control, which determines both electrical and thermal properties.
Hybrid graphene tunneling photoconductor with interface engineering towards fast photoresponse and high responsivity
Authors: Tao Li , Chen Zefeng , Li Xinming , Yan Keyou , Xu Jian-Bin
Published: June 2017

Hybrid graphene photoconductor/phototransistor has achieved giant photoresponsivity, but its response speed dramatically degrades as the expense due to the long lifetime of trapped interfacial carriers. In this work, by intercalating a large-area atomically thin MoS2 film into a hybrid graphene photoconductor, we have developed a prototype tunneling photoconductor, which exhibits a record-fast response (rising time ~17 ns) and a high responsivity (~3 × 104 A/W at 635 nm illumination with 16.8 nW power) across the broad spectral range. We demonstrate that the photo-excited carriers generated in silicon are transferred into graphene through a tunneling process rather than carrier drift. The atomically thin MoS2 film not only serves as tunneling layer but also passivates surface states, which in combination delivers a superior response speed (~3 orders of magnitude improved than a device without MoS2 layer), while the responsivity remains high. This intriguing tunneling photoconductor integrates both fast response and high responsivity and thus has significant potential in practical applications of optoelectronic devices.
Correction: Corrigendum: A Comparative Analysis of Community Detection Algorithms on Artificial Networks
Authors: Yang Zhao , Algesheimer René , Tessone Claudio J.
Published: June 2017

Scientific Reports 6: Article number: 30750; published online: 01 August 2016; updated: 26 June 2017. This Article contained errors. Figure 1f incorrectly showed curves for the values N = 233, 279, 335, 402, 482, and 579. The correct Figure 1 appears below. The Results section contained a typographical error under the subheading “The role of network size”.
Correction: Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma
Authors: Radhakrishnan Aneesha , Nanjappa Vishalakshi , Raja Remya , Sathe Gajanan , Puttamallesh Vinuth N. , Jain Ankit P. , Pinto Sneha M. , Balaji Sai A. , Chavan Sandip , Sahasrabuddhe Nandini A. , Mathur Premendu P. , Kumar Mahesh M. , Prasad T. S. Keshava , Santosh Vani , Sukumar Geethanjali , Califano Joseph A. , Rangarajan Annapoorni , Sidransky David , Pandey Akhilesh , Gowda Harsha , Chatterjee Aditi
Published: June 2017

Scientific Reports 6: Article number: 36132; published online: 31 October 2016; updated: 26 June 2017. This Article contains errors. The Acknowledgements section is incomplete. “We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics (IOB), Bangalore.
Enhanced enzymatic activity from phosphotriesterase trimer gold nanoparticle bioconjugates for pesticide detection
Authors: Hondred John A. , Breger Joyce C. , Garland Nate T. , Oh Eunkeu , Susumu Kimihiro , Walper Scott A. , Medintz Igor L. , Claussen Jonathan C.
Published: June 2017

A significant enzymatic enhancement of phosphotriesterase has been demonstrated when immobilized on various sized gold nanoparticles.
Retrospective case study on the suitability of mid-infrared microscopic imaging for the diagnosis of mucormycosis in human tissue sections
Authors: Pallua J. D. , Unterberger S. H. , Pemberger N. , Woess C. , Ensinger C. , Zelger B. , Lass-Flörl C. , Lackner M.
Published: June 2017

MIR microscopic imaging with subsequent PCA clustering is a very promising tool for the detection and identification of mucormycetes in pathology routine laboratories.
Targeted delivery of geranylgeranylacetone to mitochondria by triphenylphosphonium modified nanoparticles: a promising strategy to prevent aminoglycoside-induced hearing loss
Authors: Wang Zhenjie , Kuang Xiao , Shi Jia , Guo Weiling , Liu Hongzhuo
Published: June 2017

TPP induced and GGA loaded mitochondria-targeting nanoparticles could efficiently protect hair cells from damage.
NiMn2O4 as an efficient cathode catalyst for rechargeable lithium–air batteries
Authors: Li Shuling , Xu Jin , Ma Zhong , Zhang Shiming , Wen Xiufang , Yu Xuebin , Yang Jun , Ma Zi-Feng , Yuan Xianxia
Published: June 2017

Intermediate spinel structured NiMn2O4-FT performs better than normal spinel oxide NiMn2O4-PH as a cathode bi-functional catalyst for Li–air batteries.
New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells
Authors: Moitra Parikshit , Kumar Krishan , Sarkar Sourav , Kondaiah Paturu , Duan Wei , Bhattacharya Santanu
Published: June 2017

A new pH-sensitive co-liposomal formulation was developed which could efficiently transport doxorubicin across the DOX-resistant cancer cells.
A high-spin square planar iron(ii)-siloxide and its tetrahedral allogon – structural and spectroscopic models of Fe-zeolite sites
Authors: Pinkert D. , Keck M. , Tabrizi S. Ghassemi , Herwig C. , Beckmann F. , Braun-Cula B. , Kaupp M. , Limberg C.
Published: June 2017

The so far closest molecular model for the α-Fe sites in Fe-zeolites faithfully mimics the unique structure and spectroscopic features.
Unidirectional motion of a camphor disk on water forced by interactions between surface camphor concentration and dynamically changing boundaries
Authors: Gorecki Jerzy , Kitahata Hiroyuki , Suematsu Nobuhiko J. , Koyano Yuki , Skrobanska Paulina , Gryciuk Marian , Malecki Maciej , Tanabe Takahiro , Yamamoto Hiroya , Nakata Satoshi
Published: June 2017

Dynamically changing boundaries induce unidirectional motion of a camphor disk on water, which is regarded as a signal diode.
Luminescent lanthanide metal–organic frameworks for chemical sensing and toxic anion detection
Authors: Wu Rui-Zhi , Yang Xing , Zhang Liang-Wei , Zhou Pan-Pan
Published: June 2017

A co-doped lanthanide metal–organic framework (LnMOF) consisting of anion affinity sites exhibits self-calibrating, high distinguishable and stable photoluminescent signals for detecting toxic anions.
Exploring the bulk-phase structure of ionic liquid mixtures using small-angle neutron scattering
Authors: Cabry Christopher P. , D’Andrea Lucía , Shimizu Karina , Grillo Isabelle , Li Peixun , Rogers Sarah , Bruce Duncan W. , Canongia Lopes José N. , Slattery John M.
Published: June 2017

Small-angle neutron scattering experiments, supported by molecular dynamics simulations, have been performed on a range of compositions of the [C2mim]1−x[C12mim]x[Tf2N] ionic liquid mixture system.
Hypoglycemic effects of a Fructus Mori polysaccharide in vitro and in vivo
Authors: Chen Chun , Huang Qiang , Li Chao , Fu Xiong
Published: June 2017

Mulberry fruit polysaccharide (MFP), one of the major active ingredients isolated from the mulberry fruit, possesses numerous bioactivities.
Exploring the immunomodulatory and anticancer properties of zerumbone
Authors: Haque Md. Areeful , Jantan Ibrahim , Arshad Laiba , Bukhari Syed Nasir Abbas
Published: June 2017

Plant-derived immunomodulators and anti-cancer agents have attracted a lot of interest from natural product scientists for their efficacy and safety, and their significant contribution towards understanding targeted drug action and drug delivery mechanisms.
Investigating the role of MoS2/reduced graphene oxide as cocatalyst on Cu2O activity in catalytic and photocatalytic reactions
Authors: Akbarzadeh Elham , Rahman Setayesh Shahrbanoo , Gholami Mohammad Reza
Published: June 2017

Synergistic effect of MoS2/rGO as cocatalyst on Cu2O catalytic and photocatalytic activity.
Gd–Sn alloys and Gd–Sn–graphene composites as anode materials for lithium-ion batteries
Authors: Han Qigang , Yi Zheng , Cheng Yong , Wu Yaoming , Wang Limin
Published: June 2017

Gd–Sn alloys and Gd–Sn–graphene composites are prepared by a simple route. GdSn6/G composites have higher reversible discharge capacities than Gd–Sn powders.
An NIR-sensitive layered supramolecular nanovehicle for combined dual-modal imaging and synergistic therapy
Authors: Guan Shanyue , Weng Yangziwan , Li Mengnan , Liang Ruizheng , Sun Chenghua , Qu Xiaozhong , Zhou Shuyun
Published: June 2017

A supramolecular nanovehicle was synthesized by the co-intercalation of indocyanine green (ICG) and doxorubicin (DOX) into Gd3+-doped layered double hydroxides (LDHs) for dual-modal imaging and synergistic therapy.
A cation-exchange controlled core–shell MnS@Bi2S3 theranostic platform for multimodal imaging guided radiation therapy with hyperthermia boost
Authors: Li Yuhao , Sun Yun , Cao Tianye , Su Qianqian , Li Zili , Huang Mingxian , Ouyang Ruizhuo , Chang Haizhou , Zhang Shuping , Miao Yuqing
Published: June 2017

A core–shell MnS@Bi2S3 nanostructure was fabricated for tri-modal imaging including CT, MRI, and PA guided thermo-radio synergistic therapy.
Nanoparticle-encapsulated baicalein markedly modulates pro-inflammatory response in gingival epithelial cells
Authors: Li Xuan , Luo Wei , Ng Tsz Wing , Leung Ping Chung , Zhang Chengfei , Leung Ken Cham-Fai , Jin Lijian
Published: June 2017

Nano-BE down-regulates the IL-1β-induced expression of IL-6 and IL-8 in human gingival epithelial cells through effective delivery and cellular internalization approaches.
Size dependent structural and polymorphic transitions in ZnO: from nanocluster to bulk
Authors: Viñes Francesc , Lamiel-Garcia Oriol , Illas Francesc , Bromley Stefan T.
Published: June 2017

We report on an extensive computational modelling survey of (ZnO)N nanostructures ranging from bottom-up generated nanoclusters to top-down nanoparticles cuts from various bulk polymorphs. The obtained results enable us to follow the energetic preferences of structure and polymorphism in (ZnO)N systems with increasing N up to the bulk.
Self-assembling covalent organic framework functionalized magnetic graphene hydrophilic biocomposites as an ultrasensitive matrix for N-linked glycopeptide recognition
Authors: Wang Jiaxi , Li Jie , Gao Mingxia , Zhang Xiangmin
Published: June 2017

The flow chart of the recognition process for N-linked glycopeptide by using a MagG@COF-5 biocomposite.
Synthesis of metastable hard-magnetic ε-Fe2O3 nanoparticles from silica-coated akaganeite nanorods
Authors: Tadic Marin , Milosevic Irena , Kralj Slavko , Mitric Miodrag , Makovec Darko , Saboungi Marie-Louise , Motte Laurence
Published: June 2017

We present a novel synthesis route for preparing metastable hard-magnetic ε-Fe2O3 nanoparticles by annealing SiO2@β-FeOOH nanorods.
Enantioselective synthesis of cyclic quaternary α-amino acid derivatives by chiral phosphoric acid catalysis
Authors: Wang Lei , Rahman Abdul , Lin Xufeng
Published: June 2017

Development of highly enantioselective aza-Friedel–Crafts reaction of N-sulfonyl cyclic ketimines with indoles catalyzed by chiral phosphoric acids, providing an efficient route to indole-containing chiral cyclic α-amino acid derivatives bearing quaternary stereocenter in high yields and up to 98% enantioselectivity.
Intermolecular sulfenoamination of alkenes with sulfonamides and N-sulfanylsuccinimides to access β-sulfonylamino sulfides and dihydrobenzothiazines
Authors: Liu Tao , Tian Jun , Gao Wen-Chao , Chang Hong-Hong , Liu Qiang , Li Xing , Wei Wen-Long
Published: June 2017

An acid-catalyzed intermolecular sulfenoamination of alkenes is developed with sulfonylamides as the N-source, enabling the synthesis of β-sulfonylamino sulfides and dihydrobenzothiazines.
RAFT-mediated, visible light-initiated single unit monomer insertion and its application in the synthesis of sequence-defined polymers
Authors: Fu Changkui , Huang Zixuan , Hawker Craig J. , Moad Graeme , Xu Jiangtao , Boyer Cyrille
Published: June 2017

In this communication, we report a catalyst-free methodology for single unit monomer insertion (SUMI) into reversible addition–fragmentation chain transfer (RAFT) agents initiated by low intensity visible light.
The terpolymerization of ethylene and propylene with isoprene via THF-containing half-sandwich scandium catalysts: a new kind of ethylene–propylene–diene rubber and its functionalization
Authors: Tan Rui , Shi Zhenghai , Guo Fang , He Lv , Han Li , Li Yang
Published: June 2017

A novel family of ethylene–propylene–isoprene terpolymers was prepared by the terpolymerization of ethylene and propylene with isoprene catalyzed by the half-sandwich scandium complexs.
Metal–organic gels of silver salts with an α,β-unsaturated ketone: the influence of anions and solvents on gelation
Authors: Das Debarati , Biradha Kumar
Published: June 2017

A bis-pyridyl substituted α,β-unsaturated ketone was shown to form MOGs with silver salts having anions BF4, ClO4, CF3SO3 and SF6 in various organic solvents. They have shown selectivity towards adsorbing an anionic dye from a mixture of cationic and anionic dyes.
An amino-substituted perylene diimide polymer for conventional perovskite solar cells
Authors: Zhang Mingyu , Li Tengfei , Zheng Guanhaojie , Li Liang , Qin Meng , Zhang Shiming , Zhou Huanping , Zhan Xiaowei
Published: June 2017

An amino-substituted conjugated polymer (PPDI-F3N) is synthesized and used as a multifunctional interfacial layer to modify TiO2films in conventional planar perovskite solar cells, leading to a higher efficiency, better stability and reduced hysteresis.
Theoretical insights into the reaction mechanism between tetrachloro-o-benzoquinone and N-methyl benzohydroxamic acid
Authors: Wang Weihua , Guo Chao , Feng Wenling , Sun Qiao , Li Ping
Published: June 2017

The reaction mechanism between tetrachloro-o-benzoquinone and N-methyl benzohydroxamic acid has been clarified theoretically.
A two-stage pretreatment using acidic dioxane followed by dilute hydrochloric acid on sugar production from corn stover
Authors: An Shengxin , Li Wenzhi , Liu Qiyu , Li Minghao , Ma Qiaozhi , Ma Longlong , Chang Hou-min
Published: June 2017

A two-stage pretreatment method was developed to improve sugar recovery in this study.
Correction: Novel approach to synthesizing polymer-functionalized Fe3O4/SiO2–NH2via an ultrasound-assisted method for catalytic selective oxidation of alcohols to aldehydes and ketones in a DMSO/water mixture
Authors: Dehghan Mahsa , Motaharinejad Atieh , Saadat Mostafa , Ahdenov Reza , Babazadeh Mirzaagha , Hosseinzadeh-Khanmiri Rahim
Published: June 2017

Correction for ‘Novel approach to synthesizing polymer-functionalized Fe3O4/SiO2–NH2via an ultrasound-assisted method for catalytic selective oxidation of alcohols to aldehydes and ketones in a DMSO/water mixture’ by Mahsa Dehghan et al., RSC Adv., 2015, 5, 92335–92343.
Kinetics of esterification of 10-undecenoic and ricinoleic acids with near-critical and supercritical methanol
Authors: Narayan Ram C. , Lamba Neha , Javed Ariba , Madras Giridhar
Published: June 2017

FAMEs were synthesized from two different carboxylic acids using a green pathway and a new mechanistic kinetic model was developed.
Defect engineering in atomically-thin bismuth oxychloride towards photocatalytic oxygen evolution
Authors: Di Jun , Chen Chao , Yang Shi-Ze , Ji Mengxia , Yan Cheng , Gu Kaizhi , Xia Jiexiang , Li Huaming , Li Shuzhou , Liu Zheng
Published: June 2017

Defects have been engineering on the atomically-thin BiOCl nanosheets to tune the electronic structure, build abundant coordination-unsaturated active atoms with dangling bonds acts as active sites and shortens the migration distance of holes to promote holes utilization.
Facet-dependent photocatalytic properties of Cu2O crystals probed by using electron, hole and radical scavengers
Authors: Chu Chieh-Yu , Huang Michael H.
Published: June 2017

The facet-dependent photocatalytic properties of Cu2O crystals were probed by using electron, hole, and radical scavengers in the photodegradation of methyl orange.
Two-dimensional biomass-derived carbon nanosheets and MnO/carbon electrodes for high-performance Li-ion capacitors
Authors: Zhao Yuemei , Cui Yongpeng , Shi Jing , Liu Wei , Shi Zhicheng , Chen Shougang , Wang Xin , Wang Huanlei
Published: June 2017

We demonstrate the design of 2D nanostructured carbon and MnO/carbon electrodes from low-cost biomass-kapok fiber for Li-ion capacitors.
Mild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxide
Authors: Parilti R. , Alaimo D. , Grignard B. , Boury F. , Howdle S. M. , Jérôme C.
Published: June 2017

Well-defined microparticles of cross-linked poly(2-hydroxyethyl methacrylate) have been successfully produced by dispersion polymerisation in supercritical carbon dioxide at body temperature, i.e. conditions compatible with thermosensitive molecules.
A series of terpyridine-based zinc(ii) complexes assembled for third-order nonlinear optical responses in the near-infrared region and recognizing lipid membranes
Authors: Tang Yiwen , Kong Ming , Tian Xiaohe , Wang Jinghang , Xie Qingyuan , Wang Aidong , Zhang Qiong , Zhou Hongping , Wu Jieying , Tian Yupeng
Published: June 2017

Two-photon (TP) microscopy has advantages for biological imaging in that it allows deeper tissue-penetration and excellent resolution compared with one-photon (OP) microscopy.
‘Overloading’ fluorescent silica nanoparticles with dyes to improve biosensor performance
Authors: Moore Colin J. , Giovannini Giorgia , Kunc Filip , Hall Andrew J. , Gubala Vladimir
Published: June 2017

Using dye-doped silica nanoparticles (DSNP) as reporter probes, we describe a simple method of enhancing fluorescent signal and the extension of the detectable target concentration range in a proof-of-concept ‘dissolution immunoassay’.
Electronic noise analyses on organic electronic devices
Authors: Song Younggul , Lee Takhee
Published: June 2017

This review article addresses the motivation for studying electronic noises in OEDs and focuses on summarizing recent noise studies on various OEDs.
Novel green synthesis and improved solar-blind detection performance of hierarchical γ-Ga2O3 nanospheres
Authors: Ruan Mao Mao , Song Le Xin , Yang Zun , Teng Yue , Wang Qing Shan , Wang Ya Qian
Published: June 2017

High-quality γ-Ga2O3 nanospheres (diameter, 130 nm) were successfully synthesized by direct conversion of a precursor complex of Ga3+ ions and tartrate ions (L2−) in water.
Biological behaviors and chemical fates of Ag2Se quantum dots in vivo: the effect of surface chemistry
Authors: Tang Huan , Yang Sheng-Tao , Ke Da-Ming , Yang Yi-Fan , Liu Jia-Hui , Chen Xing , Wang Haifang , Liu Yuanfang
Published: June 2017

The surface chemistry of Ag2Se QDs regulated their distribution, metabolism, excretion and toxicity in mice.
A potential role of the unfolded protein response in post-transplant cancer
Authors: Bodeau Sandra , Sauzay Chloé , Pluquet Olivier , Choukroun Gabriel , Galmiche Antoine
Published: June 2017

Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically associated with skin cancers (both squamous cell carcinoma and melanoma) and renal cell carcinoma (RCC). Recent studies have shown that in addition to its immunosuppressive effects, accounted for by the inhibition of calcineurin and the modulation of the transcriptional programme of lymphocytes, CsA also directly stimulates the growth and aggressive behaviour of various cancer cells. Using renal carcinogenesis as an example, we discuss the current evidence for a role of cellular proteostasis, i.e. the regulation of the production, maturation and turnover of proteins in eukaryotic cells, in tumorigenesis arising under conditions of chronic immunosuppression. We present the recent studies showing that CsA induces the unfolded protein response (UPR) in normal and transformed kidney cells. We examine how the UPR might be important, considering in particular the genomic analyses showing the existence of a correlation between the levels of expression of the actors of the UPR, the chaperones of the endoplasmic reticulum (ER) and the aggressiveness of renal carcinoma. The UPR may offer a possible explanation for how immunosuppressive regimens based on CsA promote renal carcinogenesis. We discuss the opportunities offered by this biological knowledge in terms of screening, diagnosis and treatment of post-transplant cancers, and propose possible future translational studies examining the role of tumour proteostasis and the UPR in this context.
Economic-mathematical modelling of placement of gold recovery factory at the development of the group of territorially converged gold deposits
Authors: Yevdokimov S.I. , Meshkov Е.I. , Gerasimenko T.E.
Published: June 2017

A small volume of production, combined with the high capital costs and operating costs, is an objective reason of the reduction of investment attractiveness of deposits with reserves of gold <25 tons in the link “supply and demand”. The object of the research is a group of geographically contiguous succinct gold deposits. Economic result of the development of low-volume gold deposits will be fundamentally different if the production capacity of the company would be increased by combining geographically contiguous fields in small-group. The increase in reserves when the field is developed in a group should outpace the reduction of recoverable reserves value. It is shown that the level of production of gold margin depending on the location within the factory gold industrial area varies by no more than 4-14% when changing the transport arm of the deposit base by 20-40 km, it correlated with specific transportation cost k from 1.5 to 3.0 rubles/t · km profitability 30- 40%, and the total cost of an ounce of gold sold U$ 1000-1200. To determine the “center of gravity” of the group for each type of inventory the zone breakeven transport extracted from the feedstock crude concentrate is counted: stocks have in the center of a circle with a radius equal to the maximum possible distance for the transport of crude concentrate to a stationary (bush) gold recovery plant without economic damage to the developer that is recoverable ore value. The place of intersection obtained “break-even” circular zones is the “center of gravity” of the district, where the factory is located.
The application of multiloop diagnostics model to assess and improve the economic security of enterprises
Authors: Pluzhnikov Vladimir , Kukharenko Sergei , Shikina Svetlana
Published: June 2017

The author’s research is dedicated to the enhancement of the level of the enterprise economic safety. This task involves developing the concept of an integrated system for early prevention of dangers and threats of business activity, substantiation of procedures for regulating the activities of the enterprise in accordance with the changing external and internal factors. Multiloop diagnostics model is proposed to identify causal relations of management dysfunction. It allows you to receive an adequate assessment of the basic parameters of activity of the enterprise and accurately identify its status. Researching problems of economic safety of the enterprise such diagnostic methods as economic and logical analysis, statistical monitoring and strategic management were applied. There was made a conclusion that a qualitative assessment is a key tool of the level assessment of the enterprise economic safety, its control, and monitoring. It allows you to get reliable information about the real possibilities of the enterprise at different stages of development, to monitor and evaluate the level of economic security, find effective solutions to transition to a higher level of economic safety of the enterprise.
Game based learning of lean manufacturing: decreasing personnel resistance
Authors: Ganebnykh Elena , Altsybeeva Irina , Gurova Ekaterina
Published: June 2017

Developing production systems based on the principles of lean manufacturing is getting more and more popular nowadays. At the initial stage one of the main issues is high personnel resistance. Training helps to overcome the staff resistance. The research aims at proving a hypothesis of the positive effect of game based learning methods with imitating the production process on lessening the personnel resistance at the stage of implementing lean manufacturing in the company. The paper describes the game model worked out by the authors. This model imitates the production process consisting of successive operations. In the model two main factors influencing the productivity are taken into account: defective goods and stand by time. The model was tested at an enterprise producing children toys made of rubber and plastic. As a result, the participants have learnt some basic principles of lean manufacturing, as well as a principle of forming the key index of Overall Equipment Effectiveness (ОЕЕ). The task of lessening the personnel resistance was solved, the participants got to understand the necessity of improving the production process. The model is universal and is easily applicable to any productions and non-production processes. The authors believe the research has a broad sphere of applicability.
Construction and analysis of the production function for complex structured productions
Authors: Kharitonov Mikhail
Published: June 2017

The production function of the complex structured productions is represented as a superposition of Leontief′ s production functions corresponding to each of the modules. The optimization problem is reduced to a linear programming problem with a parameter, which describes the operational structure of the core.
Probabilistic pattern of risks in company’s Quality management system
Authors: Mager Vladimir , Leonova Tatyana , Chernenkaya Liudmila
Published: June 2017

One possible approach for calculation of probabilistic rate of risks in Quality management system (QMS), which is prescribed by requirements of International Standard ISO 9001:2015, is proposed in this article. Aspects of the theory of dependability and Markov techniques are used, which are applied for evaluation of probability of failures in complicated technical systems. Representation of QMS processes as a graph with controlled discrete Markov chains is suggested, which allows to evaluate a probability of customer requirements non-fulfillment as a function of an intensity of mistakes that bring to non-conformities in QMS.
Industry and environment: modeling the global production impact on CO2
Authors: Didenko N.I. , Skripnuk D.F. , Mirolyubova O.V.
Published: June 2017

The article analyses the impact of global industrial production on CO2 emissions. The global economy comprises such industrial sectors as the primary economic sector (mining, wood processing industry), various processing industrial sectors, energy sector, housing and communal services and transportation sectors. We present the methodology of modelling global economy industrial impact on CO2 emissions. ADL-model (autoregressive distributed lags model) has been chosen as a theoretical basis. Eight variables affecting CO2 emissions per unit of production were chosen as exogenous: the reduction of forest area; the output of energy industries, utilities and extraction industries; wood processing industry; the volume of goods transported; the volume of transportation and communications sectors; the length of roads; the output of industries producing material resources. The primary statistic information on the endogenous and exogenous variables in many countries was collected. The endogenous and exogenous parameters for global economy based on the initial statistic information were defined as the geometric mean indices in the year t. The article presents a model of the global economy industries impact on CO2 emissions. The conclusions about the impact of industrial factors on CO2 emissions are drawn.