bluuebunny/crossref_metadata_2025 huggingface dataset:
Project learning in preschool institutions
Authors: Mavric Mina , Bećirović-Alic Maida , Lipovac Vlasta
Published: March 2022

Innovations in teaching arose as a need to help traditional methods and means to achieve goals that have been set, but which traditional ways of working and behaving in teaching are not achievable, due to numerous changes in the modern world. The child of the modern world requires a different approach to work, complete individualization and commitment, with unlimited freedom. In these segments, traditional teaching makes serious mistakes, which is why innovative models are needed to improve it, such as project teaching. Project learning, as an innovative model in teaching, is the topic of this paper, through the description of its requirements, purpose, the role that the educator and the child have in it. The most important answer is how important project learning is in preschool education, when the foundations are laid for further work and development of children.
GEEDIP: Metodología de evaluación de los modelos teóricos de gestión con miras a la reconstrucción prospectiva
Authors: Soto Aguirre Neirys
Published: March 2022

La necesidad de reconversión del pensamiento gerencial con base en las concepciones que emergen en la organización demanda de la construcción de un puente entre el espacio-realidad y un modelo teorético administrativo existente, razón por la cual, esbozamos como objetivo principal desde la episteme, el diseño de la metodología GEEDIP. Esta investigación aborda la constitución transformacional desde los elementos emergentes del modelado teórico, considerando las implicaciones tanto metodológicas como conceptuales a partir de tres referentes teóricos modelísticos: Mario Bunge en el ámbito de la incompletud, Rolando García en el ámbito de la complejidad y Uskali Mäki en el ámbito económico. La estructura investigativa fue documental utilizando el método de análisis de contenido, con el propósito de construir y postular la nueva metodología. El principal hallazgo es GEEDIP que se específica en su propia definición con base en con cuatro (4) premisas esenciales: 1. Estructura Generatriz (G), 2. Estructura Existente (E), 3. Estructura Emergente (E) y 4. Dimensión Investigativa Prospectiva (DIP), esta representa marco metodológico secuencial, dotando de coherencia interna, capacidad predictiva y potencia heurística a la gestión. Para finalizar se realiza la contrastación empírica analizando el modelo de sistema viable (MSV) de Beer, determinándose una debilidad teórica respecto al capital humano y con base en GEEDIP se postula un modelo parcial emergente.
Taxonomía de la pertinencia en la educación superior ecuatoriana. Visión y acción en ECOTEC
Authors: Alfonso Caveda Duniesky , Alcívar García Gilda
Published: March 2022

El principio de pertinencia en el contexto educativo es reconocido por la Ley Orgánica de Educación Superior del Ecuador (LOES). En este sentido, la citada normativa establece parámetros que actúan a nivel macro-formativo en el ámbito universitario. Por su parte, el Reglamento del Régimen Académico (RRA) lo asume al reconocerlo como su primer objetivo y supeditar su cumplimiento al desarrollo eficiente de las funciones sustantivas, que actúan como pilares estructurales y orientadores del proceso de formación profesional. La propia visión macro-legal cumple con establecer el actuar ex lege del principio, lo que unido a la naturaleza autonómica de las instituciones universitarias brinda la base jurídica en la que se erige la formación profesional en el Ecuador. Lo expuesto, trae como consecuencia una libertad-responsabilidad de las universidades que deben cumplir con el mandato constitucional de una educación de calidad para todos. La presente investigación, desde una visión histórica lógica y de análisis documental, pretende fundamentar desde una perspectiva meso y micro, los parámetros necesarios para el logro de una formación académica y profesional con producción de conocimiento pertinente y de excelencia.
Primjena imunoterapije kod onkoloških bolesnika s bolešću COVID-19
Authors: Vučinić Damir , Zamolo Gordana , Šitum Mirna , Grahovac Blaženka , Marušić Jasna
Published: March 2022

Tijekom pandemije virusa SARS-CoV-2 onkološki pacijenti označeni su kao posebno rizična skupina. Posebnu skupinu čine pacijenti u tijeku imunoterapije inhibitorima kontrolnih točaka. Čini se kako su koristi imunoterapije u bolesti koje uzrokuje novi koronavirus potpuno potisnule početni strah od očekivanih negativnih utjecaja imunosnog sustava potaknutog inhibitorima kontrolnih točaka. Sprječavanjem iscrpljenosti CD8+ limfocita, smanjenjem razine interleukina-6 i indirektnom regulacijom neutrofila i NK stanica, imunoterapija djeluje na patofiziologiju razvoja blažih oblika bolesti COVID-19. Trenutne spoznaje ističu imunoterapiju kao sigurnu opciju onkološkog liječenja u doba pandemije COVID-19.
Association between atherogenic index of plasma and left ventricular hypertrophy in patients with chronic heart failure with mid-range ejection fraction
Authors: Nikolov Asparuh , Blazheva Svetla , Kostadinovska Ana , Kostov Konstantin , Tzekova Maria
Published: March 2022

Aim: The aim of the present study was to investigate whether an association between lipid indices- atherogenic index of plasma (AIP), Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II) and triglyceride index (TGL-index) and the development of left ventricular hypertrophy exists in patients with heart failure with mid-range ejection fraction (HFmrEF). Material and methods: The study involved 56 patients with HFmrEF and normal lipid profile, median age 64 (47-84) and 22 healthy subjects, median age 58 (51-69). The patients were divided in two subgroups: subjects with left ventricular hypertrophy (n=32); (HFmrEF+LVH) and subjects without left ventricular hypertrophy (n=24); (HFmrEF-LVH). The lipid profile was measured by laboratory, while lipid indices were calculated, using the established formulas. Results: There was not statistically significant difference between the lipid indices in patients with heart failure with mid-range ejection fraction compared to healthy controls (p>0.05). HFmrEF+LVH patients showed statistically significantly higher values of atherogenic index of plasma than HFrEF-LVH patients: 0.16 (0.05/0.37) vs. 0.04 (0.01/0.11); (KW=5.80; p=0.02). TC/HDL, LDL/HDL and TG/HDL values were not significantly higher in HFmrHEF+LVH than HFmrEF-LVH patients: 4.8 (3.98/5.75) vs. 4.49 (3.58/5.63); 2.91 (2.1/4.0) vs. 2.9 (2.5/4.25) and 1.36 (1.11/2.08) vs. 1.13 (0.9/1.53), respectively (p>0.05). No significant gender differences between lipid indices were found. Atherogenic index of plasma showed correlation with LVH (r=0.45; p=0.01) and interventricular septum thickness (r=0.55; p=0.002). Conclusion: Our findings show an association between atherogenic index of plasma and LVH in patients with HFmrEF with normal lipid profile. Further studies are warranted to confirm whether determination of AIP may be used for monitoring development and progression of left ventricular hypertrophy in heart failure with mid-range ejection fraction.
Retroperitonealna lokalizacija Castelmanove bolesti kod pedijatrijskog pacijenta
Authors: Šlabek Ema , Nikolić Harry , Bosak Veršić Ana
Published: March 2022

Cilj: Castelmanova bolest rijetko je oboljenje koje karakterizira benigna hiperplazija limfnih čvorova. Glavni je cilj prikazati Castelmanovu bolest kao mogući uzrok retroperitonealne tvorbe u pedijatrijskoj populaciji. Prikaz slučaja: Na Zavod za hematologiju, onkologiju i kliničku genetiku Klinike za pedijatriju Kliničkog bolničkog centra Rijeka zaprimljen je petnaestogodišnji dječak radi verifikacije ekspanzivne tvorbe u području burze omentalis, koja je utvrđena ultrazvukom prilikom obrade recidivirajućeg povraćanja. Naime, dječak je deset dana pred prijam svakodnevno povraćao ujutro nakon doručka u tri do četiri navrata. Ultrazvučno je bila prikazana dobro ograničena tvorba promjera 4 x 3 cm između duodenuma i pankreasa. Kompjutoriziranom tomografijom prikazala se tvorba koja se utiskivala u želudac bez znakova infiltracije okolnih struktura. Prema karakteristikama tvorbe vidljivih magnetskom rezonancijom zaključilo se da se radi o solitarnoj benignoj tvorbi. Učinjena je iglena punkcija pod kontrolom endoskopskog ultrazvuka, a na temelju citološkog nalaza postavila se klinička sumnja na Castelmanovu bolest hijalino-vaskularne varijante. Napravljena je kirurška ekstirpacija tvorbe što je ujedno i standard liječenja unicentrične Castelmanove bolesti. Patohistološka analiza potvrdila je radnu dijagnozu unicentrične Castelmanove bolesti miješane varijante. Poslijeoperacijski tijek prošao je uredno i dječak je otpušten kući dobrog općeg stanja. Na redovnim kontrolama nije bilo znakova recidiva osnovne bolesti. Zaključak: Iako je Castelmanova bolest rijetka, pogotovo retroperitonealne lokalizacije i u pedijatrijskoj populaciji, treba je uvrstiti u diferencijalnu dijagnozu pri pronalasku tumorske tvorbe na toj lokalizaciji.
Prolazna eritroblastopenija djetinjstva i infekcija COVID-19
Authors: Šimić Dora , Roganović Jelena
Published: March 2022

Cilj: Istaknuti važnost uključivanja prolazne eritroblastopenije djetinjstva u diferencijalnu dijagnozu anemije u prethodno zdravog malog djeteta kako bi se izbjegle nepotrebne dijagnostičke i terapijske intervencije te opisati utjecaj infekcije virusom SARS-CoV-2 na tijek i ishod bolesti. Prikaz slučaja: Djevojčica u dobi od dvije i pol godine bila je upućena na hitnu bolničku obradu zbog teške anemije. Kod prijama je bila dobrog općeg stanja, bez subjektivnih tegoba, s bljedoćom kože i sluznica, urednog ostalog somatskog statusa. Premorbidna i obiteljska anamneza bile su negativne. Ponovljeni nalazi potvrdili su izoliranu tešku normocitnu normokromnu anemiju. Praćen je spontani oporavak crvene loze. Interkurentna infekcija COVID-19 s udruženom neutropenijom i trombocitopenijom utjecala je na tijek, ali ne i na povoljan ishod bolesti. Postavljena je dijagnoza tranzitorne eritroblastopenije djetinjstva s komplikacijama uslijed infekcije COVID-19. Liječenje je bilo potporno. U daljnjem tijeku bila je praćena ambulantno, do potpunog oporavka anemije dva mjeseca nakon hospitalizacije. Zaključak: Prolazna eritroblastopenija djetinjstva stečeni je samoograničavajući poremećaj, karakteriziran anemijom i retikulocitopenijom uslijed zastoja eritropoeze u prethodno zdravog djeteta. Evaluaciju treba usmjeriti na isključenje drugih uzroka anemije. Infekcija COVID-19 ne utječe na povoljan ishod bolesti.
Oral frenula in newborns: When should you refer for evaluation and intervention?
Authors: Buchanan Tyler , Purnell Phillip , Carr Michele
Published: March 2022

Ankyloglossia is a common congenital anomaly, characterized by limited tongue mobility because of anatomical restriction by the lingual frenulum. The reduced tongue mobility has been associated with breastfeeding difficulty. Consensus on the functional effect of ankyloglossia is lacking and a small minority of pediatricians and otolaryngologists believe it affects feeding. A larger proportion of lactation specialists believe ankyloglossia contributes to feeding issues. Diagnostic assessment tools can guide the appropriateness of surgical correction in cases of ankyloglossia. Recent attention has been directed to the role of the maxillary frenulum in breastfeeding difficulty. We will review current literature on both topics with the aim to clarify when pediatric patients should be referred for appropriate surgical intervention.
Initial Clinical Experience with PCSK9 Inhibitors to Lower LDL Cholesterol in a University Lipid Clinic Setting
Authors: Morise Anthony , Tennant Jennifer , Holmes Sari , Tacker Danyel
Published: March 2022

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have demonstrated significant lowering of low-density lipoprotein (LDL) cholesterol in patients with atherosclerotic cardiovascular disease (ASCVD) and familial hypercholesterolemia (FH). We retrospectively reviewed data concerning use of PCSK9 inhibitors from patients in our university-based adult lipid clinic. Data collected included clinical pre-treatment variables and pre-and post-treatment non-fasting lipid profiles. Of 165 candidates, 163 were approved for PCSK9 inhibition (90% ASCVD and 10% FH). A majority of patients (72%) had statin intolerance. Treatment was provided and assessed in 141 patients. After three doses of medications, LDL cholesterol fell from 170 + 58 mg/dL to 76 + 45 mg/dL (55%, P<0.001). There were no differences in efficacy according to sex, elevated lipoprotein(a), and the PCS-K9 inhibitor utilized. Continued efficacy was evaluated in 101 patients with LDL decreasing further from initial follow-up to long-term follow-up over an average of 14 months (74 ± 44 mg/dL to 68 ± 41 mg/dL). Permanent discontinuation of PCS-K9 inhibitor because of side effects occurred in 11% of patients. When strict adherence to guidelines was applied, >95% approval rate was obtained, and there was similar efficacy in LDL lowering to what has been previously reported irrespective of statin intolerance.
Potentially Avoidable Acute Care Patient Transfers to a Rural Academic Medical Center
Authors: Nair Dilip , Gibbs Mary , Gress Todd , Barker Shawndra
Published: March 2022

Though inter-facility acute care patient transfers from resource-limited rural hospitals are necessary, it is desirable to minimize them for several reasons. Some transfers might be potentially avoidable with appropriate pre-transfer teleconsultation. We conducted a retrospective record review of adult patient transfers to our rural academic medical center for medical-surgical services or critical care to estimate the frequency of potentially avoidable patient transfers and to identify any re-quested specialty that was more often associated withpotentially avoidable patient transfers. Excluded were patients transferred via trauma network or for obstetrics care. Transfers were judged potentially avoidable if resulting in live discharge within 48 hours without procedures or intensive care. We studied patient demographics and transferring facility characteristics.We examined 1,180 transfers between June 2016 and January 2017 and judged 21.6% (N=255) potentially avoidable. Transfers for Neurology consultation were 2.5 times (95% CI 1.2 -5.0) more likely to be avoidable relative to transfers for General Surgery. Neurology was the only specialty associated with a greater likelihood of potentially avoidable transfers than the comparator specialty.A significant proportion of inter-facility patient transfers to our facility are potentially avoidable. Neurology-related transfers might warrant pre-transfer teleconsultation.
Evidence-Based Strategies to Prevent Eating Disorders and Obesity in Children
Authors: Luzier Jessica , Jeffrey Jamie
Published: March 2022

Eating disorders (EDs) and obesity (OB) are both chronic health problems that often emerge during childhood and adolescence. Both conditions are difficult to treat and may pose serious medical and behavioral health effects. In the following review article, prevalence and common health consequences of both EDs and OB in youth are presented, followed by a summary of literature describing the interaction between the two conditions. Best practice prevention strategies and specific physician action steps are then out-lined. These include (1) discouraging restricting diet behavior and using behavioral strategies to encourage nourishing eating habits (including 5-2-1-0 plan), (2) promoting positive body image, (3) eating frequent family meals, (4) encouraging and modeling positive body talk and (5) addressing weight stigma and bullying related to weight.
Aspectos epidemiológicos del control antimalarico en un país libre de infecciones autóctonas, Chile
Authors: Mercado Rubén , Peña Sebastián , Tassara Renzo , Urarte Edurne , Denegri Marisol
Published: March 2022

Objetivo. Realizar análisis bibliográfico referente a malaria importada en Chile. Materiales y métodos.  Se revisaron publicaciones periódicas, informes y boletines epidemiológicos publicados en Chile entre 1945 y 2020. Los casos se tabularon en una base de datos en términos de número de casos, género, nacionalidad y/o procedencia. Datos de presencia del vector se recopilaron en términos de localidad de muestreo. Resultados. Veinticuatro casos de malaria importados (13 chilenos) al territorio se notificaron en el periodo. Entre 1990 y 2001 hubo 66 nuevos casos, hombres (75,8%). Entre 2011 y 2019 se comunicaron 114 nuevos casos,uno de ellos mortal, (único fallecimiento desde el año 2005). En el rango de edad de 25-45 años se concentra la mayoría de los infectados. En forma continua, se ha detectado mayoritariamente criaderos naturales de mosquitos Anopheles pseudopuntipennis en zona norte del país. Conclusiones. El aumento de los viajes internacionales de chilenos y de la tasa de inmigración de extranjeros podría haber aumentado la notificación. La ausencia de casos autóctonos se habría logrado por el diagnóstico precoz, aislamiento, tratamiento y eliminación de focos de crianza de Anopheles. Desde el 2004 malaria es enfermedad de notificación obligatoria inmediata en Chile.
Foco activo de Malaria, Resguardo Indígena Caño Mochuelo, Casanare, Colombia 2020 – 2021.
Authors: Zuleta Dueñas Liliana Patricia , Camacho Gómez Malenna , Ospina Patricia Angélica , Fábregas Ricardo Fabian
Published: March 2022

Casanare en la Orinoquía colombiana, presenta bajo reporte de casos de malaria. Entre la semana epidemiológica (SE) 28 a la SE-49 de 2020 se reportaron 77 casos. 61% hombres, 9% migrantes, 2.6% malaria complicada, letalidad: 1.3% (1/77); mortalidad: 0.06/100.000 habitantes. En la SE-3 a la 13 de 2021 se notificaron 51 casos con la misma procedencia. Objetivo. Caracterizar la situación eco-epidemiológica de un foco de malaria. Materiales y métodos. Estudio descriptivo: análisis epidemiológico (Índice Parasitario Anual-IPA, tasa de mortalidad y letalidad), verificación de atención integral del paciente y estudio entomológico. Resultados.  En 2021 los casos observados superaron los esperados (51 vs 7), (p=0.000).  51% mujeres. 32% primera infancia y adolescencia, 25% jóvenes, 39% adultos, 4% adulto mayor, sin mortalidad, colombianos, de nueve comunidades indígenas.  El IPA en 2020 y 2021 fue 0.18 y 0.12. La verificación diagnostica de gota gruesa sugirió reentrenamiento del personal operativo. Anopheles braziliensis, A. darlingi, A. marajoara y A. oswaldoi se identificaron. Mayor actividad de picadura de A. darlingi: entre las 21:00h-22:00h. Entorno de mayor captura: intra-domicilio. Viviendas con intervención química: 340. Toldillos impregnados con insecticida entregados: 500. Conclusión. Se confirma la existencia de un foco receptivo en estrato 4. Se debe priorizar el evento con acciones de vigilancia, prevención y control.
Características sociodemográficas de estudiantes adolescentes con violencia familiar y bajo rendimiento académico, de una institución, Montería 2018
Authors: Orozco Gómez Cleiver , Cogollo Jiménez Regina , Castellón Canabal Yuleidis Paola
Published: March 2022

La violencia es reconocida como un problema de Salud Pública. De acuerdo con lo definido por la OMS y OPS, es uno de los principales factores que contribuyen a la muerte, la enfermedad y la discapacidad. Objetivo. Determinar las características sociodemográficas de estudiantes de secundaria de una institución académica de Montería con bajo rendimiento académico y violencia familiar.  Materiales y métodos. Descriptivo, transversal, con enfoque cuantitativo. La muestra fue de 45 estudiantes entre 14 y 18 años, que presentaron bajo rendimiento académico. Resultados. En los estudiantes adolescentes predomina la edad de 14 años (42%), el género masculino (60%), octavo grado con una incidencia de 60%. Predomina la violencia física con un 44%, seguida de la violencia psicológica con un 33%; el 38% siempre tienen dificultades en su rendimiento académico. Conclusiones. La mayoría de los estudiantes adolescentes están en el grupo de edad de 14 años (adolescencia media), género masculino, estudian octavo grado y siempre tienen dificultades en su rendimiento académico. Un porcentaje significativo de la población estudiada presentó violencia física y psicológica, caracterizándose por golpes e insultos, siendo necesario intervenciones a nivel familiar donde se promueva principios y valores.
Evidence-Based Behavioral Strategies in Smartphone Apps for Children’s Sleep: Content Analysis
Authors: Simon Stacey L , Kaar Jill L , Talker Ishaah , Reich Jennifer
Published: March 2022

Background

Empirically supported treatments for pediatric sleep problems exist, but many families turn to other sources for help with their children’s sleep, such as smartphone apps. Sleep apps are easy for families to access, but little evidence exists regarding the validity of the services and information provided in the developer descriptions of the apps.

Objective

The goal of this study was to examine the features and claims of developer descriptions of sleep apps for children.

Methods

A search of the Apple iTunes store and Google Play was conducted using the terms “kids sleep,” “child sleep,” and “baby sleep.” Data on the type of app, price, user rating, and number of users were collected. Apps were analyzed in comparison with evidence-based behavioral strategies and were thematically coded on the basis of claims provided in developer descriptions.

Results

A total of 83 app descriptions were examined, of which only 2 (2.4%) offered sleep improvement strategies. The majority were sound and light apps (78%) and 19% were bedtime games or stories. Only 18 of 83 (21.6%) apps were identified as containing empirically supported behavioral sleep strategies. Despite this, many apps asserted claims that they will help children “fall asleep instantly,” “cry less and sleep better,” or improve child development.

Conclusions

A large variety of sleep apps exist for use among children, but few include evidence-based behavioral strategies according to the developer descriptions of the apps. Addressing sleep difficulties in children is important to promote physical, cognitive, and emotional development. Collaboration between sleep researchers and technology developers may be beneficial for creating evidence-supported apps to help with children’s sleep in the future.
Features of the Personal Anxiety and Mental Rigidity Ratio in the Structure of Alexithymia
Authors:   Kursk State Medical University, Zdanovich Anna I. , Plotnikov Dmitry V. ,   Kursk State Medical University, Belskikh Irina A. ,   Kursk State Medical University, Levchenko Elena V. ,   Kursk State Medical University
Published: March 2022

The purpose of the current study was to determine the components of personal anxiety and mental rigidity, the significance of their severity and combination in the structure of alexithymia. Materials and methods. The study was conducted on 377 apparently healthy men and women aged 20-25 years. The assessment of the level of alexithymia in points was carried out using the 20-item Toronto Alexithymia Scale in the Russian version, then all participants were passed the Differential Assessment of Personal Anxiety Test and the Differentiated Mental Rigidity Assessment Test to determine the corresponding characteristics. The study participants were divided by gender, and each group into subgroups depending on the level of alexithymia severity. Results. Analysis of the average values revealed an increase in both the general levels of personal anxiety and mental rigidity with an increase in alexithymic potential, and individual components of these signs. A factor analysis was performed to identify the ratios of personal anxiety and mental rigidity components depending on alexithymia severity. It was revealed a three-factor structure with the greatest loads on the affective and cognitive components. With correlation analysis, the structures of the subscales of the Toronto Alexithymia Scale were investigated, and it was revealed that they are, to a high degree of probability, formed by various combinations of personal anxiety and mental rigidity components. Conclusion. The investigation confirmed the complex heterogeneous and multidimensional structure of the alexithymic potential and the essential role of various ratios of personal anxiety and mental rigidity components in its profile.
Vulvar Squamous Cell Carcinoma: the Relevance of Tumor HPV-Status
Authors:   Clinical and Diagnostic Center of Yekaterinburg, Pakharukova Maria I. , Yuzhakova Irina S. ,   Ural Federal University the first President of Russia Boris N. Yeltsin, Institute of Natural Sciences and Mathematic, Lagereva Yulia G. ,   Science Institute of Immunology and Physiology, Ural Department of the Russian Academy of Sciences, Beikin Yakov B. ,   Clinical and Diagnostic Center of Yekaterinburg
Published: March 2022

The purpose of the study was to study the role of human papillomavirus (HPV) in the etiopathogenesis of vulvar squamous cell carcinoma and it significance for survival and treatment. Material and Methods. The relevant sources were searched and analyzed in the PubMed, Cochrane Library and e-library systems from 2000 to 2021. Results. True estimation of the DNA HPV and his prognostic role in vulvar cancer has not been fully understood yet and still debatable. The inconsistent results may be due to the low frequency of the tumor and, in connection with this, the small sample of patients for the study as well as the limited geography of the study. Conclusion. Further study of HPV infection as a biomarker for predicting the course of the disease is of great interest, since the HPV status can be used to select treatment tactics as well as to monitor patients.
A CASE PRESENTATION ON OFLOXACIN INDUCED DERMAL HYPERSENSITIVITY REACTION
Authors: DIVYA BHAVANAM , THANKACHAN LEDO
Published: March 2022

Ofloxacin is a second-generation fluoroquinolone and is highly effective against a wide range of bacterial infections. Fluoroquinolones are well-tolerated drugs with mild-to-moderate adverse effects such as gastrointestinal disturbances, skin reactions, and neurological reactions. These are widely used antimicrobials, which can cause cutaneous ADRs in about 1%–2% of patients. Hypersensitivity reactions due to ofloxacin are found rarely, ranging in frequency from 0.4% to 2%, respectively. This case report highlights one such event of cutaneous ADR by the use of ofloxacin injection causing Injection site reaction after a few minutes of Ofloxacin infusion. Based on history and clinical examination patient was diagnosed as ofloxacin induced hypersensitivity reaction and was successfully treated with antihistamines and corticosteroids. General management of ADR includes withdrawal/suspension, dose reduction of the suspected drug, and administration of supportive therapy. In this case, the suspected drugs were withdrawn and the patient was treated symptomatically. Pharmacovigilance should be a part of patient care to reduce the occurrence of adverse drug reactions and also encourage practitioners in reporting to gather more and more data regarding adverse drug reactions.
Due to the rarity of Ofloxacin induced ADRs this article sheds light on one of such cases to help in pharmacovigilance
ROLE OF ANTIDEPRESSANTS AGAINST LEISHMANIASIS
Authors: MALLICK KEYA , BANERJEE SUGATO
Published: March 2022

The disease, Leishmaniasis is a forlorn, tropical, vector-borne disease caused by the kinetoplast protozoan, an obligate intracellular parasite of the class Leishmania, which is transmitted by the nibble of female sandfly (Phlebotomus). Leishmaniasis is an incurable rare disease, since the organism developed resistance towards the currently used drugs, including pentavalent antimonials, amphotericin B and miltefosine. The mechanisms involved in drug resistance include reduced expression and mutations in AQP1, mutations in miltefosine transporters like, LMT and/or LRos3 and increased expression of drug efflux transporters like, ABC transporters in the parasitic cells. Hence alternate therapeutics against leishmaniasis is the need of the hour. Here we discuss the therapeutic potential of antidepressants as potential antileishmanial agents.
Comparison of Transportation Problem in Operation Research
Authors: S Dhivya Bharathi , Ramya M.
Published: March 2022

Abstract: In Operations Research, the transportation problem is one of the predominant area and it is widely used as a decision making tool in many fields. We report the basic feasible solution and hence the methods to attain the optimal solution of the balanced transportation problem. Keywords: Transportation Problem, North-West Corner Method, Least Cost Method, Vogel’s Approximation Method.
Design and Development of IoT based Industrial Gas Leakage Monitoring System
Authors: Mourya Sirapu
Published: March 2022

Abstract: Gas leakages are a hazardous threat to living beings present in the vicinity and cause serious health issues when exposed. Employees need to constantly monitor the situation and if any leak occurs he/she needs to make the right decisions which sometimes may be prone to error. A system needs to be created that bypasses human intervention and constantly monitors around the clock. The input to the system is given by a sensor whose sensitivity depends on the gas it needs to detect. The concentration of the gas is directly proportional to the voltage output. On receiving the information, a microcontroller operates an alarm, monitoring system and displays the output with the help of LCD, LEDs. An Internet of Things (IoT) infrastructure is created in such a way that people, who are connected to the same Wi-Fi, will get a message and authorities present outside the organization will get an email via a cloud-based applet wherein officials can monitor using data analytics platform from a safe location via the internet. Officials will be able to monitor all the areas placed with a sensor on a single dashboard. From the dashboard, the data is received by a microcontroller which then initiates the sprinkler system. The microcontroller, present at the leak, operates a solenoid valve thereby directing the sterilizing agent at the site of the leak. Keywords: Gas Detection System, Sensor, Alarm, Monitoring System, IoT Infrastructure, Cloud-Based Applet, Data Analytics.
Adders implemented on VLSI for high-speed ALU
Authors: Jain Meeth , Ramesh KB
Published: March 2022

Abstract: This study focuses on the development of high-speed adder circuits utilising the Hardware Description Language (HDL) within the Xilinx ISE 9.2i platform, as well as their implementation on Field Programmable Gate Arrays (FPGAs) to analyse planning parameters. The main building component of the Arithmetic Logic Unit (ALU) is the adder, and hence the performance of the Control Processing Unit is determined by it (CPU). The ALU and the register file are the two primary components of processors. The carry-chain extra operation could be one of the important channels within an ALU. In this paper, we've simulated and synthesised a variety of adders in order to find the most efficient one. Keywords: Adders, ALU, CPU, High speed adders, delay
Nithya Kalyana Special Program in Month of Shravana of Murughamath of Chitrhradurga under the Blessings of Dr. Sri. Shivamurthy Murugha Sharanaru- A Study
Authors: S. Ananda.
Published: March 2022

Abstract: Nithya Kalyana-Which means there are two terms Nithya and Kalyana, Nithya which means Daily, Kalyana means Welfare. So totally the meaning of Nithya Kalyana, Daily welfare of Society, especially poor, needy, physically disabled person. Welfare is the good fortune, health, happiness, prosperity, etc., of a person, group, or organization; well-being:Welfare is the state of good health, happiness and comfort or financial assistance from the government.The month of Shravana is coming in August and September, The Indian Society especially in Karnataka traditional citizens worshiping the Cobra or Snake, Cobra is a representative of god that is believe of traditional citizens. And they practiced the Milk infusion. But scientifically the Cobra can’t drink liquid food. Especially the traditional citizens Milk infusion on Stone Cobra, and Worshipping the Stone Cobra. That is meaningless practice, no use to anybody, So many peoples, children, dying daily without food in country. In this situation, we are citizen of India we must create the general awareness among the traditional citizens about meaningless practices. But they can’t listen of our suggestions. The vigilance programme conducted by Three Vidha Dasohigalu, [Education, Food, Occupation] [THREE TYPES DONER] Dr.Shivamurthy Murugha Sharanaru of Murugha math. Keywords: DR.SHARANARU, MURUGHAMATH, DASOHA, EDUCATION, WORK, NITHYA KALYANA, WELFARE, CHILDEREN.
A Review Paper on Intelligent Home Automation Using Goggle Assistant
Authors: Nardelwar Miss. Sanjana , Junghare Mr. Saket , Dhawale Mr. Aditya , Gokhale Miss Nayan , Hassan Prof. Mohammad , Gyanchandani Dr. Neetu
Published: March 2022

Abstract: We are living in a world that's fleetly evolving in terms of automation. Automation is the capability to record events for bias connected to a original network or the Internet through time- related or encouragement- started programs. Smart energy effective intelligent home automation system is proposed that can pierce and control home appliances from every corner of the world. In order to make the operation more stoner friendly,web grounded and android grounded technologies have gained their significance in this slice edge technology. Determining the operating time of home appliances requires tuning a number of parameters according to the available energy supplied to the smart home. The seeing of colorful variables outdoors is done using the NodeMCU-ESP8266 microcontroller board, which allows real time data seeing. Home automation is grounded on multimodal operation which can be operated using the stoner's voice recognition commands using Google Assistant or through web grounded operation and It's using MQTT is presented for transferring entering data from detectors. Wireless networks enable multiple electronics widgets to use the same network connection without physical contact. It enables mobile widgets similar as smart phones, laptops, iPods and tablets to mobile freely within the content space and still maintain connectivity to the network. Keywords: Home Automation, Node MCU (ESP8266), Internet of Things (IoT), Google Assistant, Voice Control, Smartphone
Study on Red Signal Violations and Development of Prototype for Automated Enforcement System
Authors: A S Ranjith , A Revathi , S Dr Lakshmi , M Porchelvan , R Ponmuthuram , T Vinoth Kumar
Published: March 2022

Abstract: The violation of red signal are the major reasons for the occurrence of numerous accidents at intersections. An effort has been made to study the current rate of red signal violation in different road networks in Chennai which accounted for 18.27% and also to provide profile of red signal violation with various parameters. Road inventory survey was done at four selected intersections. The primary survey was conducted and 29743 samples were collected and analysed. The result of study provided scalable indicators for monitoring and evaluating road safety strategies to prevent red light violation in the country. The present research work also made an attempt to introduce an automatic traffic control system based on RFID technology and digital image processing. Then developed a prototype to identify red signal violation automatically with penalty system. These findings represent some useful reactions to improving road safety of urban functions in India and other developing countries. Keywords: Red signal violation, Traffic volume count, RFID, Road safety, Automatic traffic control system.
Astragalus membranaceus infusion effect on rats learningin the radial maze
Authors: Karetnikova AlenaYu. Yu. , Matvienko Uliana. A. , Savinova Daria. A. , Denikaeva Elvira. A. , Durnova Natalya A.
Published: March 2022

Relevance. Treatment of cognitive impairment is a serious problem for modern medicine. Alzheimers disease and Parkinsons disease are chronic progressive neurodegenerative diseases and the most common cause of progressive dementia in the elderly. There is no effective therapy for these diseases, so it is necessary to search for integrated therapies, including herbal medicine. The aim was to study a short-term and long-term memory of rats in the test eight-arm radial maze under the influence of repeated administration of an aqueous extract of the herb Astragalus membranaceus (Fisch.) Bunge. Materials and Methods. The experiment was carried out on 18 non-linear rats, divided into 3 groups - control and 2 experimental. For 21 days, the animals received daily intragastric caffeine at a dose of 5 mg/kg, infusion an aqueous extract of Astragalus membranaceus (Fisch.) Bunge at a dose of 100 mg/kg. The control was injected with drinking water by weight. To study the cognitive functions of the maze, performing two series of tests - at 2-7 and 16-21. Results and Discussion. In the course of the study, it was found that when the animals were tested for 2-7 days, there were no significant changes between the groups. With an increase in the duration of administration of the test substances by the 16-21 days of the experiment, in the second test series, an increase in memory points was observed both in the second (caffeine, 5 mg/kg) and in the third ( Astragalus membranaceus (Fisch.) Bunge, 100 mg/kg) of the experimental groups. Conclusion. The introduction of caffeine at a dosage of 5 mg/kg influenced the activation of short-term and long-term memory with a duration of more than 17 days of administrationat the 2nd stage of testing. Astragalus membranaceus (Fisch.) Bunge (100 mg/kg) caused the activation of working and long-term spatial memory from the 16th day of the experimenton the 2nd series of tests.
Nursing process application in Nepal teaching hospital
Authors: Katel Kalpana
Published: March 2022

Relevance. Nursing process is a scientific method of organizing and providing nursing care. Due to imbalance of nurse patient ratio, application of nursing process in actual clinical setting is very limited which reduces the quality nursing care. Despite the importance of application of nursing process, there is no standard nursing process protocol available in the hospital where study was carried out. The governments set a standard nurse patient ratio in Nepal, UK and USA is 1:10, 1:8, and 1:5 respectively. However, global statistic has been revealed due to improper nurse patient ratio which cannot implement the nursing process for patient caring which are being for leading cause of mortality of patient in hospitals. Aim of the study. The study was conducted to assess the application of the nursing process among nurses working in teaching hospital. Additionally, this study explores the association between status of application of nursing process and selected variables. Materials and Methods. Based on a descriptive cross-sectional study design. A simple random sampling technique was applied for nurses working in tertiary hospital of Chitwan, Nepal. The data was collected using structured questionnaire among 182 nurses. The statistical analysis tool chi-square was used to find out the association and logistic bivariate to find out the odds ratio. Results and Discussion. The result indicates that only 23.1 % of nurses have moderate level of application of nursing process. Majority of nurses did not follow standard ways of nursing process. This study also explored the influencing variable for barriers related to nurses and profession. Age (p=0.001), professional qualification (p=0.001) and learning approach (p=0.022) were the significant influencing variable for barriers related to nurses whereas practical skill (p= 0.001), cooperation among nurses (p=0.008) and difficulty in diagnosis characteristic (p=0.010) were the barrier related to profession. Conclusion. It was concluded that the majority of nurses working in teaching hospital of Nepal did not follow the standard ways of nursing process so that barriers for the application of nursing process are identified. The overall ratio of nurses to patients in the teaching hospital is 1:16, that is in the lower range than the standards set by the government. Therefore, special attention must be paid to adherence to a standardized nursing process protocol for quality medical care.
Features of the contemporary settlement system on the Crimean Peninsula
Authors: Gusakov T. Y.
Published: March 2022

In the 20th century, humanity finally chose the urban path of development as a priority. In the 21st century, the state strategic plans focus on large cities and urban agglomerations under the continuing urbanization. Rural territories are increasingly perceived by the authorities and urbanists as some dying forms, sacrificed for the development of cities. In the Russian Federation, this is especially true for a number of regions (Moscow Region, Sverdlovsk Region, Yamal-Nenets Autonomous District, etc.), in which municipalities are turned into urban districts, and all administrative functions are transferred to the cities. The countryside is still rural, but its population is practically removed from decision-making. At the same time, there are reverse migrations - of urban dwellers to the countryside, which leads to further expansion of cities. The term settlement system means a set of settlements located in a certain territory and connected by a common organization of management, services and labor market. Therefore, the Crimean region has both - overpopulated rural areas and developing cities. The article considers the settlement system of the Crimean Peninsula, in particular its urban part, as a basis of its demographic development. Based on statistical, cartographic, regional and historical approaches, the author considers the dynamics of urban settlement and such a phenomenon as urban agglomerations; identifies the main factors in the development of urban settlements, the subsystems of the urban settlement system and its central places. The article also describes the Simferopol-Sevastopol dual-core agglomeration which seems to break up into two autonomous agglomerations due to a range of factors.
Temporality of social care in the pandemic context of urbanism and culture of inclusion
Authors: Yarskaya-Smirnova V. N. , Yarskaya-Smirnova E. R. , Zaitsev D. V.
Published: March 2022

The article presents the results of the sociological analysis of the temporal aspects of social care in the new conditions of the pandemic reality. The pandemic is considered as a set of conditions and factors that determine the specific dynamics of societal transformations that affect almost all aspects of the life of society including its temporality - the present and future. Digital technologies, distant models of social relations, mobility and cohesion become priorities for social policy and social care. The pandemic, on the one hand, exacerbates social inequality, on the other hand, levels it out in the ways of self-realization (network technologies), ways of obtaining benefits, primarily from the state (digital social, financial and other services). The pandemic has a binary impact on the practices of social care, programs and technologies for social services, social support, social assistance, and social protection. These practices are most effectively carried out in urbanized areas, where the quality of social care is partly determined by the quality and availability of the relevant urban infrastructure. Based on the results of the new Russian and foreign research presented at the conference under review, the forms, values and resources of social care in the pandemic society are described together with the specifics of distant culture and social inequality in the contemporary city, barriers to mobility (digital, social-perceptual, social-legal), challenges, actors and discourses of social work, lockdowns of social life.
Employment of the elderly: Social imperatives and barriers in contemporary Russia
Authors: Barkov S. A. , Markeeva A. V. , Kolodeznikova I. V.
Published: March 2022

Based on the expert survey of the Russian HR-managers on the employment of the elderly (the project Specifics of employment and career of the elderly in contemporary Russia was conducted in November 2020 - January 2021), the authors present the ideas of HR-managers on the problems in the employment of the elderly and strategies to solve them in the current Russian conditions. In the post-industrial society, older generations can, want and often need to work. The main motives for their employment are not only economic - the need to have an additional income (urgent need for money, feeling of financial independence, need to help children), but also social motives (fear of losing a proactive lifestyle, loss of social status and ability to keep social networks). According to the HR-specialists, older workers have many positive qualities for employment; however, some of these qualities are considered as the elderlys willingness to accept any (non-prestigious and low-paid) job. Educational programs for older workers are underdeveloped in Russian organizations: even if there are such, they are formal or created by public employment services. Experts are positive about the states support for the employment of older people and consider it a primary condition for improving the situation. At the same time, experts support traditional administrative measures that require some budget funding. The survey identified age discrimination as the most important problem of the elderlys employment as based on the stereotypes of HR-managers. Solving this problem seems to be the most important condition for improving the employment of older people in Russia - by developing educational programs, improving the institution of mentoring (in direct and reverse forms) and fair assessment of the older job candidates.
INOVAÇÃO NO PROCESSO DE ARRECADAÇÃO DE IPTU COM A IMPLANTAÇÃO DO PIX
Authors: Lemos da Silva João Victor
Published: March 2022

O novo método de pagamento denominado PIX, lançado em 2020, tem um grande potencial para ser inserido no setor público. Um exemplo disso é o pagamento do Imposto sobre a Propriedade Predial e Territorial Urbana - IPTU, por meio desta ferramenta já incorporada em algumas cidades brasileiras. Com isso, a pesquisa buscará responder o questionamento: “Como o PIX poderá ser uma alternativa de inovação na arrecadação do IPTU?’’ Dessa maneira, o estudo possui como objetivo geral apresentar o pagamento de IPTU via PIX como uma alternativa de contribuição. Conivente a isso, os objetivos específicos buscam apontar os impostos coletados no Brasil, o IPTU nos municípios, descrever o método de pagamento PIX e, por fim, apresentar, dentro do setor público brasileiro, alguns entes que adotaram o PIX como possibilidade de pagamento do IPTU na sua estrutura, evidenciando, com precisão, a alternativa de contribuição para o setor. A metodologia de pesquisa escolhida para desenvolver este trabalho foi através da pesquisa exploratória, por meio do método de revisão bibliográfica. Por fim, é de conhecimento que os processos atuais de pagamentos demoram dias e alguns demandam tempo, deixando de ser prático. Por meio de procedimentos inovadores como o pagamento de impostos via PIX, através da internet, é proporcionada agilidade e praticidade nos procedimentos de compensação do imposto coletado.