bluuebunny/crossref_metadata_2025 huggingface dataset:
De la New Left à la Fake Left : les Cultural Studies et la crise de la réalité
Authors: Ouellet Maxime
Published: April 2023

Cet article a pour intention de saisir l’évolution des Cultural Studies dans le contexte des transformations structurelles qui affectent les sociétés capitalistes avancées dans le cadre du passage de la modernité vers la postmodernité. Nous verrons que l’intention initiale des Cultural Studies visait à poser les bases d’une théorie sociologique qui trouvait son expression politique dans le socialisme démocratique. S’opposant à la fois à l’économicisme, au positivisme et à l’utilitarisme qui étaient partagés autant par le marxisme vulgaire que par le libéralisme, le matérialisme culturel des fondateurs des Cultural Studies a cherché dans la culture populaire un ensemble de traditions qui s’opposaient à la logique universaliste abstraite du capitalisme industriel et qui pourraient établir les fondements normatifs d’une société socialiste à venir. Par la suite, en branchant le marxisme structuraliste althussérien sur la French Theory, les théoriciens des Cultural Studies se feront les principaux protagonistes de la politique des identités et de la guerre culturelle qui sévira aux États-Unis à partir des années 1980. Nous soutenons que le tournant postmoderne des Cultural Studies participe d’une crise générale des modalités de reproduction des sociétés capitalistes avancées qu’on peut qualifier de crise de la réalité. Cette crise se manifeste notamment dans le conflit qui oppose une droite postmoderne, la Alt-right, à la Fake Left, une gauche de la simulation, qui s’exprime notamment dans les médias sociaux et sur les campus universitaires.
Michel Foucault, de la « pensée du dehors » au « capital humain »
Authors: Labelle Gilles
Published: April 2023

Une fréquentation même sommaire et partielle de l’immense littérature qui a été consacrée à Michel Foucault révèle qu’elle repose en grande partie sur une décontextualisation de l’oeuvre. Dans un souci de contextualiser celle-ci, je défendrai trois arguments : 1) le rejet de la « pensée dialectique », dont la phénoménologie est le cas le plus récent suivant Foucault, doit être considéré comme structurant tout son travail, de l’Histoire de la folie à l’âge classique à l’Histoire de la sexualité et au cours de 1979 consacré au libéralisme et au néolibéralisme. 2) Cette posture constitue une prise de position à l’égard des principes qui structurent ce qu’on peut désigner comme le monde moderne ou la modernité. À la pensée dialectique, Foucault oppose d’abord ce qu’il désigne comme « pensée du dehors », qui correspond à ce que Hegel désignait comme « pensée de l’entendement » en ce qu’elle pose l’existence d’oppositions irréductibles et indépassables. L’exemple paradigmatique de cette pensée désignée par Hegel comme pensée du « ou bien… ou bien… » est donné dès le départ de l’oeuvre de Foucault : ou bien la déraison (dont la folie est un cas), ou bien la raison. Ce qui est dès lors rejeté est l’idée de synthèse ou de réconciliation entre les éléments contradictoires dont hérite la modernité (par exemple entre l’idée de totalité et celle de liberté), qui caractérise selon Foucault la pensée dialectique dans ses diverses déclinaisons, hégélienne, marxienne et phénoménologique. 3) Cette prise de position à propos de la pensée dialectique et de la modernité permet de situer Foucault dans l’actualité immédiate où s’est déployée son oeuvre – la critique de la colonisation d’abord, le gauchisme post-soixante-huitard ensuite, ce qu’on peut désigner comme le « post-gauchisme » enfin – et éclaire en partie au moins la réception dont elle a fait l’objet.
Juguetes trágicos para adultos: sexualidad y perversiones del cuerpo en las bañistas de Picasso (Dinard, verano de 1928)
Authors: Iáñez Picazo Javier
Published: April 2023

El presente artículo busca ofrecer un análisis en torno a un conjunto de pinturas de pequeño formato que Pablo Picasso realizó durante sus vacaciones en Dinard el mes de agosto de 1928. Estas supusieron una transformación pictórica radical, además de una breve etapa fascinante que afianzaron decisivamente las perversiones monstruosas del cuerpo y su sexualidad en la obra del pintor malagueño. Para ello, será necesario hacer un breve repaso sobre los años anteriores a 1928 para comprender el origen de esta fractura pictórica, además de destacar su huella en algunos cambios significativos que Picasso adoptará en su pintura posterior a esta misma fecha.
Los libros y los tapices como transmisores de memoria educacional femenina en el entorno cortesano de las Habsburgo-Trastámara
Authors: Salazar Escar Alejandra
Published: April 2023

Asociada al interés por la (re)presentación de una imagen ideal, la labor educativa jugó un relevante papel en el modelado de la condición femenina bajomedieval, sirviéndose de determinadas piezas para potenciar la transmisión de valores asociados con la virtud, el decoro y la devoción requeridas para una dama en la época. A través de este estudio trataremos de identificar las similitudes existentes entre los patrones educacionales asociados al uso de los libros y los tapices como transmisores sensoriales de instrucción femenina, ofreciendo nuevas lecturas acerca de su reciprocidad funcional y los parámetros de significación vinculados a su transmisión. Ambos compartían temáticas moralizantes e instructivas, así como un mismo espacio para su disfrute sensorial y potenciales “lecturas femeninas” asociadas con la memoria familiar y la emulación de patrones de comportamiento y actuación bien delimitados.
Discutiendo la identidad del “Maestro de Alzira”. Gaspar Godos, pintor del retablo de Santiago (Valencia, 1538).
Authors: Gómez-Ferrer Lozano Mercedes
Published: April 2023

La localización del contrato fechado el 23 de febrero de 1538 con el pintor Gaspar Godos para el retablo de Santiago permite confirmar la hipótesis de que este autor es el anónimo conocido en la bibliografía como Maestro de Alzira. Tres tablas de este retablo se encuentran en el Museo de Dublín y otra en la colección particular Laia-Bosch. Constituyen uno de los retablos más importantes de este maestro, que ahora sabemos procedía de una capilla situada en el monasterio de San Francisco de la ciudad de Valencia, patrocinada por la noble Yolant Serra y de Centelles, sobrina del cardenal Jaume Serra. Gracias a estas aportaciones se permite ahondar en la personalidad de este artista cuya trayectoria discurre entre Valencia y Aragón durante la primera mitad del siglo XVI.
Al voltant del «pregascó» de Joan Coromines. Fitònims amb una vocal àtona final aparentment anòmala en occità aranès
Authors: Carrera Aitor
Published: April 2023

En consonància amb els fets fonètics precatalans que Joan Coromines va trobar en el territori del català nord-occidental pirinenc (i sobretot al Pallars), aquest mateix lingüista va referir-se a fets de fonètica pregascona a la veïna Vall d’Aran, per als quals fins i tot va suggerir una frontera territorial exacta. En aquest treball no només mostrem que aquesta frontera no existeix, sinó que ens interessem pels manteniments aparentment anòmals de -o àtona final (abundants en la toponímia) en alguns fitònims que Coromines mateix dona com a pretesos testimonis d’aquell fet lingüístic. No només sembla evident que algun cas citat pel gran lingüista català no té res a veure amb un manteniment excepcional d’aquella vocal, sinó que altres exemples poden ser comparats a formes amb -o àtona final que apareixen en múltiples zones del domini gascó en determinats contextos i per a certs referents, cosa que posa en dubte que els termes citats per Coromines puguin justificar la presència de varietats bascoides en una vall concreta.
El concepte de «estàndard» segons els paratextos dels centres codificadors oficials del català i de l’espanyol
Authors: Costa Carreras Joan
Published: April 2023

La perspectiva comparada de l’estandardologia ha estat considerada inherent al seu desenvolupament. En aquest context, el projecte ESTANDAREV (PID2021-124673NA-IOO) fa una recerca sobre l’estandardització del basc, el català, el gallec i l’espanyol. Aquest article és una aplicació d’aquesta recerca, comparant la concepció de estàndard de les acadèmies oficials del català i de l’espanyol. El primer constatable és que hi ha una oposició diametral en l’explicitesa en la definició i l’ús d’aquest terme. En aquest treball, hem analitzat els desplegaments conceptuals i els usos en totes dues llengües. Pel que fa als criteris de comparació, hem confirmat la hipòtesi que el criteri més important són els marcs teòrics i metodològics en què es poden inscriure. Hem identificat més paral·lelismes que divergències entre tots quatre centres codificadors i la distinció entre centres inicials i posterior acaba no essent rellevant, ja que tots treballen actualment i tenen moltes interrelacions entre ells.
Differential Object Marking in Spanish: the effect of affectedness
Authors: Romero Heredero Diego , García García Marco
Published: April 2023

Affectedness is a key property of patient arguments that has been shown to be an important factor for argument selection and case marking. In addition, it has been proven to be relevant for differential object marking (DOM). However, there are only few studies that investigate the influence of affectedness on DOM in Spanish. Further, previous studies have been based on corpus analyses that focus on the diachrony of DOM. This paper assumes a notion of affectedness developed within the framework of force dynamics, according to which an affected argument is defined as the recipient of the force that is specified by the verbal content. Following this definition, we present an empirical investigation based on experimental data from a forced-choice questionnaire involving 326 speakers of Modern European Spanish. The study shows that affectedness has a significant influence on the acceptability of DOM. Furthermore, a close inspection of the experimental data reveals the observation that DOM is not only favoured by the affectedness of the direct object, but also by its agentivity.
Differential object marking in Romanian: an overview
Authors: Irimia Monica Alexandrina
Published: April 2023

This article offers a descriptive overview of the most important empirical traits that characterize differential object marking (DOM) in modern standard Romanian, ranging from purely interpretive parameters to the more syntactically oriented ones. Various aspects are reviewed, among which the argumental status of Romanian differentially marked objects, despite overt prepositional marking, interactions with clitic doubling, or with the animacy and specificity scales. The final part is dedicated to a presentation of the numerous problems Romanian DOM raises for formal accounts. Against this background, it is shown that analyses which take this phenomenon to signal a mechanism at the syntax-semantics-pragmatics interface appear to be best suited for the data.
Una mirada al centenari de Joan Fuster
Authors: Carbó Ferran
Published: April 2023

Ressenya sobre els actes del centenari del naixement de Joan Fuster (1922-2022).
Tomàs Martínez Romero, «Paula, Eustòquia i la duquessa de Gandia. Traduccions antigues d’obres de sant Jeroni sobre comportament femení», Barcelona / Alacant, Institut Interuniversitari de Filologia Valenciana / Publicacions de l’Abadia de Montserrat, Col·lecció «Biblioteca Sanchis Guarner», 2022, 271 p.
Authors: Arronis Carme
Published: April 2023

Ressenya sobre el llibre de Martínez Romero, Tomàs: Paula, Eustòquia i la duquessa de Gandia. Traduccions antigues d’obres de sant Jeroni sobre comportament femení, Barcelona / Alacant, Institut Interuniversitari de Filologia Valenciana / Publicacions de l’Abadia de Montserrat, Col·lecció «Biblioteca Sanchis Guarner», 2022, 271 p., ISBN: 978-84-9191-232-3.
Josep Plantí, «La desfeta de Catalunya i la destrucció de Barcelona», introducció d’Agustí Alcoberro, traducció de Martí Duran, Martorell, Adesiara editorial, 2022, 200 p.
Authors: Medina Martínez Fernando
Published: April 2023

Ressenya sobre el llibre de Josep Plantí, La desfeta de Catalunya i la destrucció de Barcelona, introducció d’Agustí Alcoberro, traducció de Martí Duran, Martorell, Adesiara editorial, 2022, 200 p., ISBN: 978-84-16948-83-3.
Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway
Authors: Zhang Zhuo , Zhang Duoli , Wang Fang , Liu Jiao , Sun Yuhong , Anuchapreeda Songyot , Tima Singkome , Xiao Zhangang , Duangmano Suwit
Published: April 2023

Melanoma is a common skin tumor that causes a high rate of mortality, especially in Europe, North America and Oceania. Immunosuppressants such as anti-PD-1 have been used in the treatment of malignant melanoma, however, nearly 60% of patients do not respond to these treatments. Sema4D, also called CD100, is expressed in T cells and tumor tissues. Sema4D and its receptor, Plexin-B1, play crucial roles in the process of immune regulation, angiogenesis, and tumor progression. The role of Sema4D in melanoma with anti-PD-1 resistance is poorly understood. Through a combination of molecular biology techniques and in silico analysis, the role of Sema4D in improving anti-PD-L1 sensitivity in melanoma was explored. The results showed that the expression of Sema4D, Plexin-B1 and PD-L1 was significantly increased in B16-F10R cells. Sema4D knockdown synergizes with anti-PD-1 treatment, cell viability, cell invasion and migration were significantly decreased, while the apoptosis was increased, the growth of tumors on the mice was also inhibited. Mechanistically, bioinformatics analysis revealed that Sema4D is involved in the PI3K/AKT signaling pathway; the downregulation of p-PI3K/PI3K and p-AKT/AKT expression were observed in Sema4D knockdown, therefore, nivolumab resistance is related to Sema4D and Sema4D silencing can improve sensitivity to nivolumab via inhibition of the PI3K/AKT signaling pathway.
Evaluation of Potato Genotypes under High Hill Conditions of Nepal
Authors: Giri Raj Kumar , Bhusal Yubraj , Upadhyay Kalika Prasad , Chalise Basant , Subedi Giridhari , Thapa Bihani , Poudel Bishwash
Published: April 2023

Coordinated Varietal Trial (CVT) on different genotypes of potato received from National Potato Research Program (NPRP), Khumaltar, Lalitpur was carried out at Horticultural Research Station, Rajikot, Jumla at an altitude of 2396 m above mean sea level during two consecutive years 2019 and 2020 to evaluate potato genotypes suitable for the high hills of Karnali province of Nepal. Nine different potato genotypes with two checks i.e. Desiree and Jumli Local were tested on Randomized Complete Block Design (RCBD). Each treatment was replicated four times. Compost was used at the rate of 20 tons per hectare. There was no use of chemical fertilizer. Well sprouted tubers of 25-50 g were planted with 60cm x 25cm spacing. The effects of different genotypes were recorded for both vegetative as well as yield parameters. Tested genotypes differed significantly for vegetative (emergence percentage at 30 days after planting & 45 days after planting, uniformity, ground coverage, plant height, number of main stems) as well as yield parameters (total number of tubers and tuber yield per ha). The highest tuber yield (20.9 t/ha) was harvested from CIP 392797.22. Result of consecutive years showed that potato genotype CIP 392797.22 is suitable for cultivation in high hills of Karnali province for food as well as nutritional security.
Satisfaction of Basic Psychological Needs and Teaching-Learning Process of Physics in Junior Secondary Classes in Jaffna District, Sri Lanka
Authors: Vijayakumaran P. , Chandrasena W. D. , Liyanage P.
Published: April 2023

This study investigates Relations of satisfaction of basic psychological needs and teaching-learning process and achievement of physics in junior secondary classes in Jaffna District Sri Lanka; find impact of basic psychological needs on teaching-learning process. The study was descriptive and a quantitative study of 89 science teachers to  explore the relationship between teacher satisfaction of basic psychological needs and their teaching-learning process. The study also included 855 class-wise students to examine the relationship between students' satisfaction of basic psychological needs and their physics achievements. The results show that both relations ships are positively correlated, and teaching learning process can be predicted the level of 31% by the variation of teachers’ satisfaction of basic psychological needs. The findings suggest that applying SDT principles in the physics teaching-learning process can enhance teacher satisfaction to lead better classroom practice and student achievement, leading to better academic performance.
A Rare Case Report of “Torsades De Pointes” Induced by Fluconazole-Levetiracetam Combined Therapy
Authors: Mulendelé P. M. , Njie M. , Charfo M. B. , Boutar S. M. , Ovaga B. E. , Haboub M. , Arous S. , Benouna M. Ghali , Drighil A. , Azzouzi L. , Habbal R.
Published: April 2023

Drugs used to treat cardiovascular disease as well as those used in the treatment of multiple other conditions can occasionally produce exaggerated prolongation of the QT interval on the surface electrocardiogram and the morphologically distinctive polymorphic ventricular tachycardia that results is known as «torsade de pointe». «Torsade de pointe» (TDP) is a characteristic polymorphic ventricular arrhythmia associated with delayed ventricular repolarization as evidenced on the surface electrocardiogram by QT interval prolongation. It typically occurs in self-limiting bursts, causing dizziness and syncope, but may occasionally progress to ventricular fibrillation and sudden death. This rare case report showed the potential higher risk of the occurrences of «Tdp» when levetiracetam (KEPPRA) was used in combination therapy with fluconazole, which is already a known medication with the risk of causing polymorphic ventricular arrhythmia.
Sub-environments of Deposition and Facies Characteristics of the Nyaba River in Enugu Metropolis Southeastern Nigeria
Authors: Onuigbo E. N. , Okoro A. U. , Ezealajii I. P. , Ozulu G. U. , Okeke H. C.
Published: April 2023

A field study undertaken on the various sub- environments of deposition and sedimentary facies attributes of the Nyaba River in Enugu Metropolis was for a better understanding and interpretation of modern river processes and their sedimentary facies characteristics. A unique attribute of this river is its meandering characteristics at the upper reaches and minor braiding at its lower reaches. The Meandering river sub- environments and their facies are distinguished into the main meander channels/lag deposits, well -developed point bar deposits, the levees and the flood plain deposits. Abandoned channel deposits (meander cut off) is also a common characteristic of the river. Braided channel and longitudinal braid bars constitute the depositional sites of the braided river. Clasts are dominated by sandy fractions with sub-angular to sub-rounded grains. Sorting varies from poorly sorted to well sorted. Pebbles and muddy fractions also occur. Sedimentary structures consist of cross beddings on point bar sands, horizontal laminations, small current ripples, mudcracks and burrows of terrestrial organisms. Nyaba River is classified as a mixed load river.
Incubation Studies on Nutrient Release Pattern of NPK and Enzymatic Activities in Inceptisol of Andhra Pradesh, India
Authors: Kirankumar Ch. , Santhi R.
Published: April 2023

Incubation experiment was conducted with the initial bulk surface soil sample from experimental field to study the nutrient release pattern of available N, P, K and activity of soil enzymes (urease, alkaline phosphatase and dehydrogenase activity) under NPK alone, IPNS (NPK+FYM), Farm Yard Manure (FYM) alone and absolute control. As compared to all other treatments, IPNS recorded relatively higher available N, P and K status. In case of NPK alone treatments, the available N content increased up to 90 days of incubation and decreased thereafter.  In case of IPNS treatments, the status has shown an increase up to 120 DAI. Both under NPK alone and IPNS, the available P showed an increase up to 90 days after incubation and thereafter declined gradually up to 120 DAI while soil available K showed a gradual increase up to 120 DAI. Irrespective of different stages of incubation, STCR-IPNS treatments recorded comparatively higher enzymatic activity (urease, alkaline phosphatase and dehydrogenase) than STCR-NPK alone. These  findings derived from the incubation experiment brought forth the fact that the release pattern of N, P and K and enzymatic activities under NPK alone, IPNS, FYM alone and absolute control paved way for understanding the beneficial effects of IPNS on crop productivity, efficiency and economy in fertiliser application and soil fertility sustenance throughout the period of crop growth.
Quality of Life and Fatigue Symptoms of Post-Covid-19 Patients in Paraíso do Tocantins
Authors: Coelho Lukas Oliveira , Brito Gabriel Rodrigues , Moraes Lorenzo Barbosa França de , Botelho Matheus de Lima , Queiroz Maria Eduarda Sousa , Costa Maria Vitória santos Assunção , Santos Igor Fonseca dos , D’Alessandro Aline Almeida Barbaresco , Araujo Warly Neves de , D’Alessandro Walmirton Bezerra
Published: April 2023

Introduction: The long-term problems caused by COVID-19 are still unclear. The quality of life of patients may be in evidence even several months after infection. OBJECTIVE: To assess the quality of life and fatigue symptoms of post-covid-19 patients in paraíso do Tocantins. Main outcomes: Health-related quality of life assessed using the EQ-5D-5L and CFQ-11 scale.

Materials and Methods: This study has a quantitative and qualitative character, collecting data records of people affected by the symptoms of fatigue in the post-covid and describing the quality of life they are having with this problem. The field research, exploratory study, and a data collection was done through 2 questionnaires, CFQ-11 and EQ-5D-5L, all questions were answered based on the individual's situation before and after cure of covid-19, characterizing changes in physical and mental states after infection.

Results: 38 people were evaluated using the qualitative tests CFQ-11 and EQ-5D-5L. 60.53% of interviewees showed signs of fatigue from the CFQ-11 scale. For the EQ-5D-5L scale 26% and 29% of participants showed signs of moderate problems of pain/discomfort and anxiety/depression, respectively. For last, the EQ-VAS scale could show that 19 people stated to have a 70-80 health score of quality-of-life post-COVID.

Conclusion: It was observed that fatigue after COVID-19 followed a trend in other similar literature, thus stressing the notoriety of the correlation between symptoms of fatigue in the post-COVID or covid-long with the worsening their quality of life. More tests need to be done to evaluate other factors that can influence the results.
TEMPORAL
Authors: Pompeu de Barros Daltro Emyle
Published: April 2023

Resenha crítica do projeto de extensão Temporal: encontros de improvisação e composição em tempo real, vinculado aos cursos de Bacharelado e Licenciatura da Graduação em Dança, da Universidade Federal do Ceará (UFC).
DANÇA E INTERATIVIDADE
Authors: De Medeiros Misi Mirella , Martinez Pimentel Ludmila Cecilina
Published: April 2023

Traduzir uma das nossas principais referências teóricas, o professor Johannes Birringer, já seria um imenso prazer, pois se trata de um dos pioneiros autores no território da dança em interface com tecnologias digitais, desde um dos seus primeiros livros, o Media and Performance: Along the border (1998). Além disso, na função prazerosa de traduzi-lo, também temos a honra de apresentar em português o capítulo Dance and Interactivity que, mesmo datado do início do século XXI, ainda é tão atual após quase vinte anos da primeira publicação, porque nos serve como uma das principais referências teóricas na área do que intitulamos "Dança Digital". Ousaríamos dizer que se há um filósofo ou pensador contemporâneo que mais se debruçou nesse campo de investigação, este autor é Johannes Birringer, um gentil cavalheiro alemão-americano que sempre nos tratou afavelmente compartilhando seus profundos conhecimentos na área e fundador da primeira plataforma digital sobre Dança e Tecnologia, a Dance and Technology Zone (DTZ), criada nos finais dos anos 90 do século passado e que produziu inúmeros livros e artigos após esse que estamos oferecendo traduzido aqui em nossa Revista Dança. Salve, salve Birringer!
Effect of Treadmill Perturbation-Based Balance Training on Fall Rates in Community-Dwelling Older Adults
Authors: Nørgaard Jens Eg , Andersen Stig , Ryg Jesper , Stevenson Andrew James Thomas , Andreasen Jane , Oliveira Anderson Souza , Danielsen Mathias Brix , Jorgensen Martin Gronbech
Published: April 2023

Importance

Falls are common and the leading cause of injuries among older adults, but falls may be attenuated by the promising and time-efficient intervention called perturbation-based balance training (PBT).

Objective

To evaluate the effects of a 4-session treadmill PBT intervention compared with regular treadmill walking on daily-life fall rates among community-dwelling older adults.

Design, Setting, and Participants

This 12-month, assessor-blinded randomized clinical trial was conducted from March 2021 through December 2022 in Aalborg University in Denmark. Participants were community-dwelling adults 65 years or older and were able to walk without a walking aid. Participants were randomized to either PBT (intervention group) or treadmill walking (control group). Data analyses were based on the intention-to-treat principle.

Interventions

Participants who were randomized to the intervention group underwent four 20-minute sessions of PBT, including 40 slip, trip, or mixed slip and trip perturbations. Participants who were randomized to the control group performed four 20-minute sessions of treadmill walking at their preferred speed. The 3 initial training sessions were completed within the first week, whereas the fourth session was performed after 6 months.

Main Outcomes and Measures

Primary outcome was the daily-life fall rates that were collected from fall calendars for the 12 months after the third training session. Secondary outcomes were the proportion of participants with at least 1 fall and recurrent falls, time to first fall, fall-related fractures, fall-related injuries, fall-related health care contacts, and daily-life slip and trip falls.

Results

A total of 140 highly functioning, community-dwelling older adults (mean [SD] age, 72 [5] years; 79 females [56%]), 57 (41%) of whom had a fall in the past 12 months, were included in this trial. Perturbation training had no significant effect on daily-life fall rate (incidence rate ratio [IRR]: 0.78; 95% CI, 0.48-1.27) or other fall-related metrics. However, there was a significant reduction in laboratory fall rates at the posttraining assessment (IRR, 0.20; 95% CI, 0.10-0.41), 6-month follow-up (IRR, 0.47; 95% CI, 0.26-0.86), and 12-month follow-up (IRR, 0.37; 95% CI, 0.19-0.72).

Conclusions and Relevance

Results of this trial showed that participants who received an 80-minute PBT intervention experienced a statistically nonsignificant 22% reduction in daily-life fall rates. There was no significant effect on other daily-life fall-related metrics; however, a statistically significant decrease in falls was found in the laboratory setting.

Trial Registration

ClinicalTrials.gov Identifier: NCT04733222
Bilateral Hypopyon in a Young Woman
Authors: Sechrist Samantha J. , Zhang Yi Stephanie , Brodie Frank L.
Published: April 2023

A 28-year-old woman presented to the emergency department with a 5-day history of bilateral blurry vision, eye redness, discharge, photophobia, and pain. There were more than 20 cells per high-power field of 1 mm × 1 mm beam, with fibrin bilaterally and 2.5-mm hypopyon in the right eye and 2.7-mm hypopyon in the left eye. What would you do next?
Endophthalmitis Secondary to Fish Tank Granuloma
Authors: Chen Xiaofei , Pan Xiaoying , Zhu Jian , Liu Tiecheng
Published: April 2023

This case report describes an uncommon case of endophthalmitis secondary to fish tank granuloma.
Characterization and treatment of gemcitabine‐ and cisplatin‐resistant bladder cancer cells with a pan‐RAS inhibitor
Authors: Yoshino Hirofumi , Yokoyama Seiya , Tamai Motoki , Okamura Shunsuke , Iizasa Sayaka , Sakaguchi Takashi , Osako Yoichi , Inoguchi Satoru , Matsushita Ryosuke , Yamada Yasutoshi , Nakagawa Masayuki , Tatarano Shuichi , Tanimoto Akihide , Enokida Hideki
Published: April 2023

Combination chemotherapy with gemcitabine and cisplatin (GC) is recommended as the primary treatment for advanced bladder cancer (BC). However, the benefits of this approach are limited owing to the acquisition of drug resistance. Here, we found that gemcitabine‐resistant and cisplatin‐resistant BCs do not exhibit cross‐resistance, and that these BCs exhibit different mRNA patterns, as revealed using RNA sequence analysis. To overcome drug resistance, we used the newly developed pan‐RAS inhibitor Compound 3144. Compound 3144 inhibited cell viability through suppression of RAS‐dependent signaling in gemcitabine‐ and cisplatin‐resistant BCs. RNA sequencing revealed that several genes and pathways, particularly those related to the cell cycle, were significantly downregulated in Compound 3144‐treated BCs. These findings provide insights into potential therapeutic strategies for treating BC.
Using the internet “raises the bar” for precision in self‐produced question answering
Authors: Hamilton Kristy A. , Siler Jessica , Benjamin Aaron S.
Published: April 2023

When responding to queries for information, people control thegrain size(precision–coarseness) of the information they communicate based on competing goals of accuracy and informativeness (Goldsmith & Koriat,Behavioral and Brain Sciences, 1999,19, 167). Two experiments examined whether the act of searching for answers using the internet influences the granularity of the information people later choose to report. Participants who searched the internet for answers to general information questions later provided more precise (granular) estimates to questions in the absence of the internet when compared to participants who initially answered questions from memory and participants who initially were not asked any questions. These results indicate that searching the internet influences metacognitive processes underlying decisions about the granularity of the information we choose to communicate. The internet may “raise the bar” with respect to the informativeness of the information we feel obliged to offer.
Prediction of Deposition Rate in Meniscus‐Confined Electrodeposition Based on Parameter Optimization Algorithm
Authors: Wang Xue , Xu Jinkai , Ren Wanfei , Xu Zhenming , Zou Zhaoqiang , Deng Haoran
Published: April 2023

Meniscus‐confined electrodeposition (MCED) is a potential approach to fabricate 3D metallic microstructures and can be used in microelectromechanical systems, optoelectronics, and flexible electrical interconnections. However, deposition efficiency and the quality of the microstructures obtained by this method on optimal parameters are identified by a large number of comparative experiments, resulting in high cost and inefficient practices. For this reason, herein, the fabrication process of metal microstructures by MCED simulation and optimizes parameters affecting deposition quality and rate is investigated. First, the finite‐element method is used to simulate the voltage and copper ion concentration identifies the target range. Then, the electrodeposition rate 1 × 10−7 m s−1 is set as the target value. The best applicable values of 0.29 V and 0.46 m are obtained after optimizing the voltage and copper ion concentration that affects the quality of deposited microstructures and rate of MCED based on the genetic algorithm (GA), cuckoo search (CS) algorithm, and support vector regression (SVR) algorithm. Finally, simulations and experiments are carried out according to the optimized parameters values. The results show that the maximum error of deposition rate is 7.9%. This study pioneers a new approach to achieving efficient and high‐quality deposition by MCED.
Mechanically Driven Reversible Polarization Switching in Imprinted BiFeO3 Thin Films
Authors: Wang Yue , Guo Changqing , Chen Mingfeng , Liang Yuhan , Han Haojie , Chen Hetian , Lin Yuanhua , Yi Di , Huang Houbing , Nan Ce‐Wen , Ma Jing
Published: April 2023

Mechanically driven polarization switching via scanning probe microscopy provides a valuable voltage‐free strategy for designing ferroelectric nanodomain structures. However, it is still challenging to realize reversible polarization switching with mechanical forces. Here, the mechanically driven reversible polarization switching observed in imprinted ferroelectric BiFeO3 thin films is reported, i.e., up‐to‐down switching by a sharp scanning tip and down‐to‐up switching by a blunt tip. Free energy calculations, phase‐field simulations, and piezoresponse force microscopy reveal that reversible mechanical switching arises from the interplay among the flexoelectric effect, the piezoelectric effect, and the internal upward built‐in field in BiFeO3 films. This study gains a deeper insight into the mechanism and control of mechanically driven polarization switching, and provides guidance for exploring potential ferroelectric‐based electro‐mechanical microelectronics.
Deepening Insights into Aggregation Effect of Intermolecular Charge‐Transfer Aggregates for Highly Efficient Near‐Infrared Non‐Doped Organic Light‐Emitting Diodes over 780 nm
Authors: Xue Jie , Xu Jingyi , Liang Qingxin , Dai Yu , Wang Rui , Yi Yuanping , Qiao Juan
Published: April 2023

Though urgently needed, high‐efficiency near‐infrared (NIR) organic light‐emitting diode (OLED) is still rare due to the energy‐gap law. Formation of intermolecular charge‐transfer aggregates (CTA) with nonadiabatic coupling suppression can decelerate non‐radiative decay rates for high‐efficiency NIR‐OLEDs. However, the aggregation effect of CTA is still not fully understood, which limits the rational design of CTA. Herein, two CTA molecules with a same π‐framework but different terminal substituents are developed to unveil the aggregation effect. In highly ordered crystalline states, the terminal substituents substantially affect the molecular packing motifs and intermolecular charge‐transfer states, thus leading to distinct photophysical properties. In comparison, in amorphous states, these two CTA demonstrate similar photophysical behaviors and properties due to their similar molecular packing and intermolecular interactions as evidenced by molecular dynamics simulations. Importantly, the formations of amorphous CTA trigger multifunction improvements such as aggregation‐induced NIR emission, aggregation‐induced thermally activated delayed fluorescence, self‐doping and self‐host features. The non‐doped OLEDs demonstrate NIR emissions centered at 788 and 803 nm, and high maximum external quantum efficiencies of 2.6% and 1.5% with small efficiency roll‐off, respectively. This study provides deeper insight into the aggregation effect of CTA and lays a foundation for the development of high‐efficiency NIR non‐doped OLEDs.
Boosting the Na‐Ion Conductivity in the Cluster‐Ion Based Anti‐Perovskite Na2BH4NH2
Authors: Jiang Ruohan , Song Changsheng , Yang Jinghao , Zhao Jie , Fang Fang , Song Yun , Sun Dalin , Wang Fei
Published: April 2023

Solid‐state sodium‐ion/metal batteries (SSSBs) are highly desirable for next‐generation energy storage systems, while very limited Na‐ion solid‐state electrolytes are explored. The borohydride‐based solid electrolytes are expected to achieve the high energy density target, due to their low redox potential, low Young's modulus as well as high stability toward alkali metals. However, the biggest challenge of borohydride‐based electrolyte is the low ionic conductivity. In this study, an anti‐perovskite solid‐state electrolyte (SSE) material rich in vacancy defects is explored, Na2BH4NH2, to solve above problems. Benefitting from rich vacancy defects, a high ionic conductivity of 7.56 × 10−4 S cm−1 with a low activation energy for Na+ migration of 0.67 eV at 90 °C are achieved. The NaSn|Na2BH4NH2|NaSn symmetric cell cycles at a current density of 0.1 mA cm−2 for 500 h. Moreover, the universality of Na2BH4NH2 electrolyte is verified by TiS2 cathode, indicating that Na2BH4NH2 has good compatibility with electrode material. These outstanding performances suggest that it is a viable strategy to increase the ionic conductivity by forming vacancy defects, leading to the further development of solid electrolytes with superior properties.
Extremely Tough, Stretchable Gel Electrolytes with Strong Interpolymer Hydrogen Bonding Prepared Using Concentrated Electrolytes to Stabilize Lithium‐Metal Anodes
Authors: Tamate Ryota , Peng Yueying , Kamiyama Yuji , Nishikawa Kei
Published: April 2023

Extremely tough and stretchable gel electrolytes, which can be prepared by leveraging the strong interpolymer hydrogen bonding in concentrated lithium (Li)‐salt electrolytes, are reported. These electrolytes can be realized by optimizing the competitive hydrogen‐bonding interactions between polymer chains, solvent molecules, Li cations, and counteranions. Free polar solvent molecules, which typically impede interpolymer hydrogen bonding, are scarce in concentrated electrolytes; this feature can be exploited to prepare hydrogen‐bonded gel electrolytes with unprecedented toughness. In contrast, free solvent molecules are abundant in electrolytes with typical concentrations, yielding considerably weaker gel electrolytes. The tough gel electrolyte can be used an artificial protective layer for Li‐metal anodes, as it considerably enhances the cycling stability of a Li symmetric cell through uniform Li deposition/dissolution. Additionally, employing the gel electrolyte as the protecting layer significantly improves the cycling performance of the Li||LiNi0.6Co0.2Mn0.2O2 full cell.
Gastrointestinal‐Peristalsis‐Inspired Hydrogel Actuators for NIR‐Controlled Transport of Viscous Liquids
Authors: Zhang Liyun , Chen Linfeng , Xu Lei , Zhao Huan , Wen Ruyi , Xia Fan
Published: April 2023

Liquid transportation is fundamentally important in microfluidics, water collection, biosensing, and printing, and has attracted enormous research interest in the past decades. However, despite substantial progress, it remains a big challenge to achieve the controlled transport of viscous liquids (>100 mPa s) commonly existing in daily life and the chemical industry. Inspired by the gastrointestinal peristalsis of mammalians that can efficiently transport viscous chyme (viscosity up to 2000 mPa s) by the synergistic combination of contraction driving force and lubrication, here, the design and construction of double‐layered tubular hydrogel actuators for directional transport of highly viscous liquids ranging from ≈1000 mPa s to >80 000 mPa s under the control of an applied 808 nm laser, which is attributed to the cooperation of outer layer contraction and water film lubrication of the inner layer, is reported. It is demonstrated that the actuators are capable of transporting polymerizing liquid whose viscosity significantly increases to ≈11 182 mPa s in 2 h. This work paves a new avenue toward directional transport of highly viscous liquids, which not only expands the research scope of liquid transportation, but will spur the design of new liquid actuators with potential applications in viscous‐liquid‐based microfluidics, artificial blood vessels, and soft robots.
A Gas/phototheranostic Nanocomposite Integrates NIR‐II‐Peak Absorbing Aza‐BODIPY with Thermal‐Sensitive Nitric Oxide Donor for Atraumatic Osteosarcoma Therapy
Authors: Fang Zhijie , Zhang Jiaxin , Shi Zhenxiong , Wang Lan , Liu Yi , Wang Jiqing , Jiang Jian , Yang Die , Bai Hua , Peng Bo , Wang Hui , Huang Xiao , Li Jie , Li Lin , Huang Wei
Published: April 2023

Photothermal therapy (PTT) has received increasing interest in cancer therapeutics owing to its excellent efficacy and controllability. However, there are two major limitations in PTT applications, which are the tissue penetration depth of lasers within the absorption range of photothermal agents and the unavoidable tissue empyrosis induced by high‐energy lasers. Herein, a gas/phototheranostic nanocomposite (NA1020‐NO@PLX) is engineered that integrates the second near‐infrared‐peak (NIR‐II‐peak) absorbing aza‐boron‐dipyrromethenes (aza‐BODIPY,NA1020) with the thermal‐sensitive nitric oxide (NO) donor (S‐nitroso‐N‐acetylpenicillamine, SNAP). An enhanced intramolecular charge transfer mechanism is proposed to achieve the NIR‐II‐peak absorbance (λmax = 1020 nm) on NA1020, thereby obtaining its deep tissue penetration depth. The NA1020 exhibits a remarkable photothermal conversion, making it feasible for the deep‐tissue orthotopic osteosarcoma therapy and providing favorable NIR‐II emission to precisely pinpoint the tumor for a visible PTT process. The simultaneously investigated atraumatic therapeutic process with an enhanced cell apoptosis mechanism indicates the feasibility of the synergistic NO/low‐temperature PTT for osteosarcoma. Herein, this gas/phototheranostic strategy optimizes the existing PTT to present a repeatable and atraumatic photothermal therapeutic process for deep‐tissue tumors, validating its potential clinical applications.
NIR‐II Cyanine Nanoparticles for Imaging‐Guided Tumor Targeting Photothermal Therapy with Vitamin C Enhanced Efficacy
Authors: Huang Yurou , Ma Xiaoxie , Li Jiang , Tan Chunyan , Yin Jun
Published: April 2023

Cyanine dyes in the near‐infrared‐II (NIR‐II) region are among the most promising photothermal agents, due to their high photothermal conversion efficiency, strong tumor targeting capability, and deep tissue penetration. The application of cyanine‐based photothermal agents remains limited, however, due to the invasive nature and spread of tumors as well as the potential for inflammatory responses during the treatment process. In this work, a naphtho[cd]indolium‐based heptamethine cyanine with NIR‐II emission is utilized to prepare PEGylated nanoparticles for studies of photothermal treatment. The results demonstrate that the nanoparticles have excellent NIR‐II imaging and tumor targeting capabilities. As a result of the light harvesting property of naphtho[cd]indolium‐based heptamethine cyanine, these nanoparticles demonstrate a photothermal conversion efficiency of 61%. The tumor‐targeting properties of these nanoparticles enable them to accumulate effectively at limbs containing tumors. Photothermal therapy shows almost complete disappearance of all tumors after eight days of treatment. In addition, hematoxylin‐eosin stains (H&E stains) of major organs show no discernible lesions throughout the treatment process. Furthermore, simultaneous injection of natural vitamin C during the treatment significantly improves the therapeutic effect of photothermal therapy.
High‐Performance Multi‐Dynamic Bond Cross‐Linked Hydrogel with Spatiotemporal siRNA Delivery for Gene–Cell Combination Therapy of Intervertebral Disc Degeneration
Authors: Chen Jiaxin , Zhu Haifeng , Xia Jiechao , Zhu Yutao , Xia Chen , Hu Zehui , Jin Yang , Wang Ji , He Yong , Dai Jiayong , Hu Zhijun
Published: April 2023

Chronic inflammatory diseases, such as intervertebral disc degeneration (IVDD), which affect the lives of hundreds of millions of people, still lack effective and precise treatments. In this study, a novel hydrogel system with many extraordinary properties is developed for gene–cell combination therapy of IVDD. Phenylboronic acid‐modified G5 PAMAM (G5‐PBA) is first synthesized, and therapeutic siRNA silencing the expression of P65 mixed with G5‐PBA (siRNA@G5‐PBA) is then embedded into the hydrogel (siRNA@G5‐PBA@Gel) based on multi‐dynamic bonds including acyl hydrazone bonds, imine linkage, π–π stacking, and hydrogen bonding interactions. Local and acidic inflammatory microenvironment‐responsive gene‐drug release can achieve spatiotemporal regulation of gene expression. In addition, gene‐drug release from the hydrogel can be sustained for more than 28 days in vitro and in vivo, greatly inhibiting the secretion of inflammatory factors and the subsequent degeneration of nucleus pulposus (NP) cells induced by lipopolysaccharide (LPS). Through prolonged inhibition of the P65/NLRP3 signaling pathway, the siRNA@G5‐PBA@Gel is verified to relieve inflammatory storms, which can significantly enhance the regeneration of IVD when combined with cell therapy. Overall, this study proposes an innovative system for gene–cell combination therapy and a precise and minimally invasive treatment method for IVD regeneration.
Fast Response GaN Nanoscale Air Channel Diodes with Highly Stable 10 mA Output Current toward Wafer‐Scale Fabrication
Authors: Wei Yazhou , Chen Feiliang , Huang Ruihan , Zhao Jianpeng , Zhao Haiquan , Wang Jiachao , Li Mo , Zhang Jian
Published: April 2023

Nanoscale air channel transistors (NACTs) have received significant attention due to their remarkable high‐frequency performance and high switching speed, which is enabled by the ballistic transport of electrons in sub‐100 nm air channels. Despite these advantages, NACTs are still limited by low currents and instability compared to solid‐state devices. GaN, with its low electron affinity, strong thermal and chemical stability, and high breakdown electric field, presents an appealing candidate as a field emission material. Here, a vertical GaN nanoscale air channel diode (NACD) with a 50 nm air channel is reported, fabricated by low‐cost IC‐compatible manufacturing technologies on a 2‐inch sapphire wafer. The device boasts a record field emission current of 11 mA at 10 V in the air and exhibits outstanding stability during cyclic, long‐term, and pulsed voltage testing. Additionally, it displays fast switching characteristics and good repeatability with a response time of fewer than 10 ns. Moreover, the temperature‐dependent performance of the device can guide the design of GaN NACTs for applications in extreme conditions. The research holds great promise for large current NACTs and will speed up their practical implementation.
High‐Throughput Design of Magnetocaloric Materials for Energy Applications: MM´X alloys
Authors: Fortunato Nuno M. , Taubel Andreas , Marmodoro Alberto , Pfeuffer Lukas , Ophale Ingo , Ebert Hebert , Gutfleisch Oliver , Zhang Hongbin
Published: April 2023

Magnetic refrigeration offers an energy efficient and environmental friendly alternative to conventional vapor‐cooling. However, its adoption depends on materials with tailored magnetic and structural properties. Here a high‐throughput computational workflow for the design of magnetocaloric materials is introduced. Density functional theory calculations are used to screen potential candidates in the family of MM'X (M/M’ = metal, X = main group element) compounds. Out of 274 stable compositions, 46 magnetic compounds are found to stabilize in both an austenite and martensite phase. Following the concept of Curie temperature window, nine compounds are identified as potential candidates with structural transitions, by evaluating and comparing the structural phase transition and magnetic ordering temperatures. Additionally, the use of doping to tailor magnetostructural coupling for both known and newly predicted MM'X compounds is predicted and isostructural substitution as a general approach to engineer magnetocaloric materials is suggested.