Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Authors: Kar Siddhartha P. , Beesley Jonathan , Amin Al Olama Ali , Michailidou Kyriaki , Tyrer Jonathan , Kote-Jarai ZSofia , Lawrenson Kate , Lindstrom Sara , Ramus Susan J. , Thompson Deborah J. , Kibel Adam S. , Dansonka-Mieszkowska Agnieszka , Michael Agnieszka , Dieffenbach Aida K. , Gentry-Maharaj Aleksandra , Whittemore Alice S. , Wolk Alicja , Monteiro Alvaro , Peixoto Ana , Kierzek Andrzej , Cox Angela , Rudolph Anja , Gonzalez-Neira Anna , Wu Anna H. , Lindblom Annika , Swerdlow Anthony , Ziogas Argyrios , Ekici Arif B. , Burwinkel Barbara , Karlan Beth Y. , Nordestgaard Børge G. , Blomqvist Carl , Phelan Catherine , McLean Catriona , Pearce Celeste Leigh , Vachon Celine , Cybulski Cezary , Slavov Chavdar , Stegmaier Christa , Maier Christiane , Ambrosone Christine B. , Høgdall Claus K. , Teerlink Craig C. , Kang Daehee , Tessier Daniel C. , Schaid Daniel J. , Stram Daniel O. , Cramer Daniel W. , Neal David E. , Eccles Diana , Flesch-Janys Dieter , Edwards Digna R. Velez , Wokozorczyk Dominika , Levine Douglas A. , Yannoukakos Drakoulis , Sawyer Elinor J. , Bandera Elisa V. , Poole Elizabeth M. , Goode Ellen L. , Khusnutdinova Elza , Høgdall Estrid , Song Fengju , Bruinsma Fiona , Heitz Florian , Modugno Francesmary , Hamdy Freddie C. , Wiklund Fredrik , Giles Graham G. , Olsson Håkan , Wildiers Hans , Ulmer Hans-Ulrich , Pandha Hardev , Risch Harvey A. , Darabi Hatef , Salvesen Helga B. , Nevanlinna Heli , Gronberg Henrik , Brenner Hermann , Brauch Hiltrud , Anton-Culver Hoda , Song Honglin , Lim Hui-Yi , McNeish Iain , Campbell Ian , Vergote Ignace , Gronwald Jacek , Lubiński Jan , Stanford Janet L. , Benítez Javier , Doherty Jennifer A. , Permuth Jennifer B. , Chang-Claude Jenny , Donovan Jenny L. , Dennis Joe , Schildkraut Joellen M. , Schleutker Johanna , Hopper John L. , Kupryjanczyk Jolanta , Park Jong Y. , Figueroa Jonine , Clements Judith A. , Knight Julia A. , Peto Julian , Cunningham Julie M. , Pow-Sang Julio , Batra Jyotsna , Czene Kamila , Lu Karen H. , Herkommer Kathleen , Khaw Kay-Tee , Matsuo Keitaro , Muir Kenneth , Offitt Kenneth , Chen Kexin , Moysich Kirsten B. , Aittomäki Kristiina , Odunsi Kunle , Kiemeney Lambertus A. , Massuger Leon F.A.G. , Fitzgerald Liesel M. , Cook Linda S. , Cannon-Albright Lisa , Hooning Maartje J. , Pike Malcolm C. , Bolla Manjeet K. , Luedeke Manuel , Teixeira Manuel R. , Goodman Marc T. , Schmidt Marjanka K. , Riggan Marjorie , Aly Markus , Rossing Mary Anne , Beckmann Matthias W. , Moisse Matthieu , Sanderson Maureen , Southey Melissa C. , Jones Michael , Lush Michael , Hildebrandt Michelle A.T. , Hou Ming-Feng , Schoemaker Minouk J. , Garcia-Closas Montserrat , Bogdanova Natalia , Rahman Nazneen , Le Nhu D. , Orr Nick , Wentzensen Nicolas , Pashayan Nora , Peterlongo Paolo , Guénel Pascal , Brennan Paul , Paulo Paula , Webb Penelope M. , Broberg Per , Fasching Peter A. , Devilee Peter , Wang Qin , Cai Qiuyin , Li Qiyuan , Kaneva Radka , Butzow Ralf , Kopperud Reidun Kristin , Schmutzler Rita K. , Stephenson Robert A. , MacInnis Robert J. , Hoover Robert N. , Winqvist Robert , Ness Roberta , Milne Roger L. , Travis Ruth C. , Benlloch Sara , Olson Sara H. , McDonnell Shannon K. , Tworoger Shelley S. , Maia Sofia , Berndt Sonja , Lee Soo Chin , Teo Soo-Hwang , Thibodeau Stephen N. , Bojesen Stig E. , Gapstur Susan M. , Kjær Susanne Krüger , Pejovic Tanja , Tammela Teuvo L.J. , Dörk Thilo , Brüning Thomas , Wahlfors Tiina , Key Tim J. , Edwards Todd L. , Menon Usha , Hamann Ute , Mitev Vanio , Kosma Veli-Matti , Setiawan Veronica Wendy , Kristensen Vessela , Arndt Volker , Vogel Walther , Zheng Wei , Sieh Weiva , Blot William J. , Kluzniak Wojciech , Shu Xiao-Ou , Gao Yu-Tang , Schumacher Fredrick , Freedman Matthew L. , Berchuck Andrew , Dunning Alison M. , Simard Jacques , Haiman Christopher A. , Spurdle Amanda , Sellers Thomas A. , Hunter David J. , Henderson Brian E. , Kraft Peter , Chanock Stephen J. , Couch Fergus J. , Hall Per , Gayther Simon A. , Easton Douglas F. , Chenevix-Trench Georgia , Eeles Rosalind , Pharoah Paul D.P. , Lambrechts Diether 
Published: April 2023

<p>Supplementary Table S1. Known risk loci for each cancer. Supplementary Table S2. Regions where known index SNPs for at least two of the three cancers lie within 1 Mb of each other. Supplementary Table S3. Full results from the meta-analysis of breast, ovarian, and prostate cancer showing the 18 independent loci associated at P < 10-8 with the same direction of effect across all three cancers. Supplementary Table S4. Conditional analysis of the rs1469713 (breast-ovarian-prostate cancer) signal, conditioning on the rs4808801 (breast cancer-specific) signal that was < 1 Mb away using GCTA software. Supplementary Table S5. Most significantly-associated genotyped SNP at new loci where index SNPs were imputed. Supplementary Table S6. Expression QTL analysis results from the GTEx Portal for the new cross-cancer risk loci listed in main Table 2. Supplementary Table S7. SNPs with P < 10-8 at the new cross-cancer risk loci listed in main Table 2 that overlap predicted enhancers in at least two cell types. Supplementary Table S8. HaploReg and non-coding RNA annotation of variants with P < 10-8 at the new cross-cancer risk loci listed in main Table 2. Supplementary Table S9. Eight of the 32 genes involved in induction of apoptosis through DR3 and DR4/5 Death Receptors (MSigDB: Biocarta "Death Pathway") a that were < 1 Mb away from an independent P < 10-5 index SNP in the 3-cancer meta-analysis. Supplementary Table S10. INRICH pathway analysis results for pathways with empirical P < 0.05. Apoptosis-related pathways containing BCL2L11 are shaded.</p>