bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence of use and users of image- and performance-enhancing drugs in sports in Switzerland: a scoping literature review and implications for Swiss drug policy
Authors: Kruijver Muriel , Bruggmann Philip , Magnolini Raphael
Published: May 2023

BACKGROUND: “Image- and performance-enhancing drugs” are widely used in sports worldwide to improve body image and performance goals. In view of the growing research interest and use of these substances, and the paucity of data on the situation in Switzerland, we conducted a scoping literature review on evidence of the use and users of these substances in Switzerland.

METHODS: A scoping review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) statement. We searched PubMed/Medline, Embase and Google Scholar for articles published before August 2022. Primary outcomes were evidence of the use and users of image- and performance enhancing drugs in Switzerland. We used a narrative synthesis approach for data analysis.

RESULTS: Overall, 18 studies were reviewed, which in total comprised 11,401 survey participants, 140 interviews and 1368 toxicologically analysed substances. Articles were mostly peer-reviewed (83%) and mostly included evidence from professional athletes (43%). The mean publication year was 2011. In most articles both outcomes (78%) were evaluated simultaneously. We demonstrate that image- and performance-enhancing drugs appear to be prevalent among athletes and non-athletes in Switzerland. A wide variety of substances exist, and the type of substances used varied by age, motivation, sex and sports discipline. The main motivations for using these substances were, among others, image- and performance enhancement. The main route of acquisition of these substances was the Internet. Furthermore, we demonstrated that substantial proportions of these substances, as well as supplements, may be counterfeit. Information on image- and performance-enhancing drug use was acquired from different sources.

CONCLUSIONS: Although evidence of image- and performance-enhancing drug use and its users in Switzerland is scarce and there are major gaps, we demonstrate that these substances are also prevalent among athletes and non-athletes in Switzerland. Furthermore, high proportions of substances acquired from unregulated drug markets are counterfeit, which puts users in a situation of unpredictable risk when consuming them. Overall, the use of these substances may pose a substantial risk to individual and public health in this possibly growing and often insufficiently informed and medically neglected user community in Switzerland. There is a great need for future research, as well as prevention, harm-reduction and treatment programmes for this hard-to-reach user community. Doping policies in Switzerland should be critically reviewed as simple medical care and evidence-based treatment for non-athlete image- and performance-enhancing drug users is excessively criminalized under the current legislature, leaving possibly over 200,000 image- and performance-enhancing drug users in Switzerland with inadequate medical care.
Splenic rupture or infarction associated with Epstein-Barr virus infectious mononucleosis: a systematic literature review
Authors: Toti Johannes M. A. , Gatti Beatrice , Hunjan Isabella , Kottanattu Lisa , Faré Pietro B. , Renzi Samuele , Bianchetti Mario G. , Milani Gregorio P. , Lava Sebastiano A. G. , Camozzi Pietro
Published: May 2023

BACKGROUND: Epstein-Barr virus (EBV), also known as human herpesvirus 4, is one of the most common pathogenic viruses in humans. EBV mononucleosis always involves the spleen and as such it predisposes to splenic rupture, often without a trauma, and splenic infarction. Nowadays the goal of management is to preserve the spleen, thereby eliminating the risk of post-splenectomy infections.

METHODS: To characterise these complications and their management, we performed a systematic review (PROSPERO CRD42022370268) following PRISMA guidelines in three databases: Excerpta Medica, the United States National Library of Medicine, and Web of Science. Articles listed in Google Scholar were also considered. Eligible articles were those describing splenic rupture or infarction in subjects with Epstein-Barr virus mononucleosis.

RESULTS: In the literature, we found 171 articles published since 1970, documenting 186 cases with splenic rupture and 29 with infarction. Both conditions predominantly occurred in males, 60% and 70% respectively. Splenic rupture was preceded by a trauma in 17 (9.1%) cases. Approximately 80% (n = 139) of cases occurred within three weeks of the onset of mononucleosis symptoms. A correlation was found between the World Society of Emergency Surgery splenic rupture score, which was retrospectively calculated, and surgical management: splenectomy in 84% (n = 44) of cases with a severe score and in 58% (n = 70) of cases with a moderate or minor score (p = 0.001). The mortality rate of splenic rupture was 4.8% (n = 9). In splenic infarction, an underlying haematological condition was observed in 21% (n = 6) of cases. The treatment of splenic infarction was always conservative without any fatal outcomes.

CONCLUSIONS: Similarly to traumatic splenic rupture, splenic preservation is increasingly common in the management of mononucleosis-associated cases as well. This complication is still occasionally fatal. Splenic infarction often occurs in subjects with a pre-existing haematological condition.
Change over time in functional capacity and self-perceived health status for patients with chronic musculoskeletal pain: a registry-based longitudinal study
Authors: Schütz Franziska , Haffter Eva , Meichtry André , Winteler Balz , Gantschnig Brigitte E.
Published: May 2023

BACKGROUND AND AIMS: Chronic musculoskeletal pain is a major public health problem worldwide. Both self-reported functional capacity and self-perceived health status are reduced in patients with chronic musculoskeletal pain. Previous studies mostly assessed functional capacity through self-reported questionnaires instead of objective measurements. The aim of this study, therefore, is to assess the amount of change over time and its clinical meaningfulness in functional capacity and self-perceived health status of patients with chronic musculoskeletal pain undergoing Bern Ambulatory Interprofessional Rehabilitation (BAI-Reha).

METHODS: The registry-based longitudinal cohort study with prospectively collected data from a rehabilitation programme took place in a real-life setting. Patients (n = 81) with chronic musculoskeletal pain took part in the BAI-Reha. The main outcomes were the six-minute-walk test (6MWT), the safe maximum floor-to-waist lift (SML) and the European Quality of Life and Health measure visual analogue scale (EQ VAS). Timepoints of measurement were at baseline and post-BAI-Reha (i.e., at 4 months). The quantity of interest was the adjusted time effect (point estimate, 95% confidence interval, and p-value for testing the null hypothesis of no change over time). Statistical significance (α = 0.05) and clinical meaningfulness of the mean value change over time were assessed using predefined thresholds (six-minute-walk test 50 m, SML 7 kg, and EQ VAS 10 points).

RESULTS: The linear mixed model analysis showed a statistically significant change over time for the six-minute-walk test (mean value change 56.08 m, 95% CI [36.13, 76.03]; p <0.001), SML (mean value change 3.92 kg, 95% CI [2.66, 5.19]; p <0.001), and EQ VAS (mean value change 9.58 points, 95% CI [4.87, 14.28]; p <0.001). Moreover, the improvement in the six-minute-walk test is clinically meaningful (mean value change 56.08 m) and almost clinically meaningful (mean value change 9.58 points) in the EQ VAS.

CONCLUSION: Patients walk further, lift more weight, and feel healthier after interprofessional rehabilitation when compared to baseline measurement. These findings confirm and add to previous results.

IMPLICATIONS: We encourage other providers of rehabilitation for patients with chronic musculoskeletal pain to measure functional capacity with objective outcome variables and to use self-reported outcome measures in addition to self-perceived health status. The well-established assessments used in this study are suitable for this purpose.
Throughput delays: causes, predictors, and outcomes – observational cohort in a Swiss emergency department
Authors: Arnold Isabelle , Busch Jeannette-Marie , Terhalle Lukas , Nickel Christian H. , Bingisser Roland
Published: May 2023

BACKGROUND: Optimal throughput times in emergency departments can be adjudicated by emergency physicians. Emergency physicians can also define causes of delays during work-up, such as waiting for imaging, clinical chemistry, consultations, or exit blocks. For adequate streaming, the identification of predictors of delays is important, as the attribution of resources depends on acuity, resources, and expected throughput times.

OBJECTIVE: This observational study aimed to identify the causes, predictors, and outcomes of emergency physician-adjudicated throughput delays.

METHODS: Two prospective emergency department cohorts from January to February 2017 and from March to May 2019 around the clock in a tertiary care centre in Switzerland were investigated. All consenting patients were included. Delay was defined as the subjective adjudication of the responsible emergency physician regarding delay during emergency department work-up. Emergency physicians were interviewed for the occurrence and cause of delays. Baseline demographics, predictor values, and outcomes were recorded. The primary outcome – delay – was presented using descriptive statistics. Univariable and multivariable logistic regression analyses were performed to assess the associations between possible predictors and delays and hospitalization, intensive care, and death with delay.

RESULTS: In 3656 (37.3%) of 9818 patients, delays were adjudicated. The patients with delays were older (59 years, interquartile range [IQR]: 39–76 years vs 49 years, IQR: 33–68 years) and more likely had impaired mobility, nonspecific complaints (weakness or fatigue), and frailty than the patients without delays. The main causes of delays were resident work-up (20.4%), consultations (20.2%), and imaging (19.4%). The predictors of delays were an Emergency Severity Index of 2 or 3 at triage (odds ratio [OR]: 3.00; confidence interval [CI]: 2.21–4.16; OR: 3.25; CI: 2.40–4.48), nonspecific complaints (OR: 1.70; CI: 1.41–2.04), and consultation and imaging (OR: 2.89; CI: 2.62–3.19). The patients with delays had an increased risk for admission (OR: 1.56; CI: 1.41–1.73) but not for mortality than those without delays.

CONCLUSION: At triage, simple predictors such as age, immobility, nonspecific complaints, and frailty may help to identify patients at risk of delay, with the main reasons being resident work-up, imaging, and consultations. This hypothesis-generating observation will allow the design of studies aimed at the identification and elimination of possible throughput obstacles.
Molecular Characteristics of Staphylococcus aureus Strains to Carry Panton-Valentine Leukocidin Genes Isolated from Hospitalized Patients in Tehran, Iran
Authors: Amini Chakameh , Fazeli Maryam , Nasiri Mohammad Javad , Bahonar Sara , Dadashi Masoud , Haghighi Mehrdad , Miri Mirmohammad , Goudarzi Mehdi
Published: May 2023

Background: Staphylococcus aureus with concurrent resistance to antibacterial agents is emerging globally. This emergence might be due to the production of different virulence determinants, notably Panton-Valentine leukocidin (PVL). Objectives: This study aimed to investigate the genetic characteristics of PVL-positive S. aureus strains isolates from clinical samples. Methods: An epidemiological study was conducted on 65 S. aureus isolates carrying pvl genes. An antibiogram test by the disk diffusion and broth microdilution methods was conducted to assess antimicrobial resistance profiles. Results: All detected methicillin-resistant S. aureus (MRSA) isolates were confirmed by mecA polymerase chain reaction (PCR) assays. The PVL-positive isolates were characterized using multiplex PCR assay to detect staphylococcal cassette chromosome mec (SCCmec) and agr types. The PVL frequency was 19.5% and 17.6% in MRSA and methicillin-susceptible S. aureus (MSSA), respectively. Among the PVL-positive isolates, 66.2% and 33.8% were MRSA and MSSA, respectively. Multidrug resistance amounted to 84.6% of the isolates (MRSA: 61.5%, MSSA: 23.1%). Staphylococcal cassette chromosome mec III was dominated (55.8%; 24/43). The most commonly identified agr was type III (53.8%; 35/65). Resistance to vancomycin amounted to 12.3% of the isolates, and all belonged to agr type III and SCCmec type III. The frequency of inducible and constitutive clindamycin resistance among PVL-positive MRSA strains (12.3% and 26.1%) was higher than PVL-positive MSSA strains (7.7% and 15.4%). Most constitutive and inducible clindamycin resistance isolates belonged to agr type III (26.2% and 18.5%) and SCCmec type III (each 27.9%). In the present study, 32.3% of the isolates were confirmed as mupirocin resistant, and all were MRSA, 9 (42.9%) and 12 (57.1%) isolates of which exhibited high-level mupirocin resistant (HLMUPR) and low-level mupirocin resistant phenotypes. All HLMUPR MRSA isolates belonged to SCCmec III and recovered from wound samples. Conclusions: The emergence of vancomycin-resistant S. aureus strains among PVL-positive S. aureus strains in Iran is a serious alarm and seems to be becoming the greatest concern in the treatment of staphylococcal infections in the healthcare setting. The present study reinforces plausible direct transfers between community and nosocomial PVL-positive S. aureus types.
Early-Stage Vasoactive-Inotropic Score and Left Ventricular Ejection Fraction Following Cardiac Surgery: A Comparison of Two Non-invasive Heart Function Monitoring Technologies in the Prognosis of Infants
Authors: Xiaoyu Xiong , Jie Ren , Chengjun Liu , Feng Xu , Jing Li
Published: May 2023

Objectives: This study aimed to compare the efficiencies of the vasoactive-inotropic score (VIS) and left ventricular ejection fraction (LVEF) in predicting the condition and prognosis of children with congenital heart disease (CHD). Methods: We retrospectively reviewed the medical charts of 104 infants aged < 1 year who underwent cardiac surgery with cardiopulmonary bypass. The maximum and mean postoperative VIS in the first and second 24 hours [VIS (24MAX), VIS (24MEA), VIS (48MAX), and VIS (48MEA)] were recorded. Similarly, LVEF within 24 hours following surgery was monitored. Receiver operator curve (ROC), regression analysis, chi-square test, and t-test were used to analyze both heart function monitoring technologies Results: Receiver operating characteristic analysis revealed that VIS was strongly associated with adverse events and death [area under ROC (AUROC) > 0.90, P = 0.00], with the two most representative scores being VIS (24MEA) and VIS (48MAX), with cut-off points of 19.42 (sensitivity = 100%; specificity = 93.90%) and 22 (sensitivity = 100%; specificity = 93.90%), respectively for death, and 18.02 (sensitivity = 91.70%; specificity = 89.10%) and 17.75 (sensitivity = 91.70%; specificity = 90.20%), respectively for adverse events. Infants with higher VIS had significantly higher mortality, higher incidence of clinical adverse events, higher lactic acid value, and longer mechanical ventilation and ICU stay (P < 0.05). However, LVEF within 24 hours following surgery was not associated with death (AUROC = 0.65, P = 0.33) or adverse events (AUROC = 0.53, P = 0.81). Moreover, there was no significant change in the length of ICU stay, duration of mechanical ventilation, and lactate value (P > 0.05). Conclusions: Vasoactive-inotropic score at an early stage following surgery was significantly associated with the condition and prognosis of infants with congenital heart disease; however, the predictive value of LVEF within 24 hours following surgery was lower.
Evaluation of Rehabilitation Service Capacity for Mildly Disabled Institutionalized Elderly - An Analysis Based on the Hierarchical Analysis and Entropy Method
Authors: Xu Maoqiang , Mohd Hashim Asha Hasnimy , Chen Zhiwei
Published: May 2023

Background: The quality of rehabilitation services plays an important role in the health and satisfaction of society, but it still has some significant deficiencies in different aspects at the same time. It is one of the main issues in the system of rehabilitation services in all countries. Objectives: This study aimed to investigate the rehabilitation service capacity for mildly disabled older adults in nursing homes. Methods: The data were used hierarchically and assigned entropy values, the final level of rehabilitation service capacity of mildly disabled older adults in nursing homes was derived, and hierarchical analysis and entropy power methods were combined. Results: In evaluating rehabilitation services for older adults with mild disabilities in nursing homes, the weight of the first-level risk indicators was 0.1454 for the rehabilitation environment, 0.3687 for the quality of rehabilitation services, and 0.4859 for the effectiveness of rehabilitation. Conclusions: Rehabilitation environment indicators for an elderly nursing home on their privacy and anti-slip design were ranked first, rehabilitation service quality indicators on the level of rehabilitation division, respectful treatment, and humanistic care, indicating that older people in nursing homes were more important physiological and psychological rehabilitation effect indicators analysis. Rehabilitation effect indicators, independent laundry, independent toileting, bathing, and independent dressing, are especially important in nursing homes for mildly disabled older adults who prefer the change the healthy physical effects.
Perlindungan Hukum Bagi Korban Tindak Pidana Lingkungan Hidup Oleh Korporasi
Authors: Fikri Ananta Nur Rasyid  , Asnah  , Aullia Vivi Yulianingrum
Published: May 2023

In environmental crimes, if a corporation has been sentenced to a criminal sentence, it is as if the sentence has been fulfilled. Considering that environmental crimes can result in many victims, both physically and psychologically, who feel disadvantaged as a result of criminal acts committed by corporations. However, along with the number of environmental crime cases, there are also many rights of social victims and social objects that have not been fulfilled. Therefore, this research wants to find the ideal legal protection for victims of environmental crimes. This research method uses a qualitative type of literature review. Primary data source UUD RI and research journals. This data analysis uses content content. The results of the study show that the main form of legal protection for victims of environmental crimes besides the form of Corporate Social Responsibility (CSR) is environmental restoration for the benefit of environmental preservation. In resolving environmental disputes, the parties can use out-of-court channels, namely mediation or court channels with the concept of restorative justice that emphasizes the rights of victims and the interests of perpetrators of environmental crimes.
Strategi Guru Pembimbing Mengatasi Kenakalan Siswa Usia Puberttas di Sekolah Menengah Pertama (SMP) Negeri 10 Sijunjung
Authors: Zahara Rita , Pasilaputra Dodi
Published: May 2023

Social relations between male students and female students exceed the limit, are often late, act indifferent and take it easy when scolded by picket teachers. The aim of the study was to find out the strategies used by supervising teachers in dealing with the delinquency of pubertal students at SMPN 10 Sijunjung. The research method is descriptive qualitative, the key informants in this study were the Coordinator of Guidance Teachers at SMPN 10 Sijunjung, supporting informants namely school principals, subject teachers, homeroom teachers and students. Based on the research conducted, it can be stated that the guidance counselor at SMPN 10 Sijunjung has carried out alleviation of student delinquency, which is carried out through the implementation of individual counseling services, through group guidance services and through mediation services. In general it can be said that these three services have been implemented well in overcoming student delinquency, and alleviation of student delinquency at SMPN 10 Sijunjung is also carried out by increasing collaboration with student parents. In this case the school invites parents to come to school once every quarter. In the meeting discussed jointly solutions that can be done in overcoming student delinquency. From the description above, it can be concluded that the counseling teacher has carried out various strategies in dealing with student delinquency at SMPN 10 Sijunjung.
Membangun Koneksi dengan Generasi Milenial: Strategi Dakwah yang Efektif dalam Era Digital
Authors: Surbakti Muhammad Faizul Akbar , Mutiawati Mutiawati , Ritonga Hasnun Jauhari
Published: May 2023

This study aims to analyze effective da'wah strategies in building connections with the millennial generation in the digital era. The millennial generation has different characteristics and communication preferences compared to the previous generation, therefore, it is necessary to have the right approach in conveying da'wah messages to them. In this research, we explore various da'wah strategies that are effective in building connections with the millennial generation and identify the factors that influence the success of these da'wah strategies. This study uses a qualitative approach involving in-depth interviews and analysis of social media content as a data collection method. It is hoped that the results of this research will be able to provide valuable insights for da'wah activists, especially in facing challenges and opportunities in interacting with the millennial generation in the digital era.
Analisis Dampak Pembangunan Bendungan Karian pada Aspek Perubahan Sosial Ekonomi Masyarakat Desa Sukarame Kecamatan Sajira Kabupaten Lebak-Banten
Authors: Juwandi Ronni , Nida Qotrun , Bisri Lutfia Fauziah
Published: May 2023

Development in a region is certainly inseparable from the participation of all parties in the region. This becomes important when changes in an area will have a direct impact on all components in that area, including the community. Karian Dam is a megaproject of Banten Province which is located in Lebak Regency. Precisely in four sub-districts in Lebak Regency including Sajira, Maja, Cimarga, and Rangkasbitung Districts. Based on the data obtained by the researchers, the researchers chose Sukarame Village as the research location because the number of heads of families affected by the construction of this dam was counted the most among other villages in Sajira District. Of which there were 519 residents who not only lost their homes, but also other life support facilities such as rice fields, and others. Researchers want to find out more about the impacts that have arisen after the construction of the Karian Dam on the aspect of socio-economic change in the people of Sukarame Village, Sajira District, Lebak Regency, Banten. This study uses a type of descriptive qualitative method with data collection techniques of interviews, observation, and documentation. From this it was found that the welfare state of the community after land acquisition became worse for most of the community because the people of Sukarame Village had to lose their jobs as farmers and did not have the opportunity to work in other fields due to inadequate human resources, and had to lose traditions or habits. which has been attached for a long time due to the relocation of a new place of residence. In fact, the key word for compensation is stated in Law No. 2 of 2012 concerning "Land Procurement for Development in the Public Interest".
Esensi Hidup dan Mati dalam Pandangan Islam dan Buddha
Authors: Azizy Orry Anas
Published: May 2023

In Indonesia, there are five recognized religions, including Islam and Buddhism. Both of these religions believe in the end of life or death. However, each religion has different teachings in providing guidance for life to its people. Likewise in matters of charity and worship. This research raises the issue of how the essence of life and death is the view of Islam and Buddhism. The discussion of this thesis uses theological approach method. Researchers used a descriptive qualitative research method with a comparative theory approach (comparison). The result of this study is that death in Buddhism and Islam has differences. In Buddhism, it means the end of the life of the human organs with the destruction of the body or body, while in Islam, death is a separation between the spirit and the body. Regarding the nature of death, Buddhism and Islam have the same meaning. In essence death is the process of moving humans from one realm to another, but both are different about nature. In the view of Buddhism and Islam, life after death is the revival of humans to continue life in order to achieve the desired goals. In Buddhism, that goal is the attainment of happiness in the form of eternal nibhanna. Meanwhile, what Islam wants to achieve is happiness in the form of eternal heavenly pleasures and this can be achieved with the good pleasure of Allah.
Tradisi Pangeri pada Masyarakat Kuta Tinggi Kecamatan Badar Kabupaten Aceh Tenggara
Authors: Arlita Novia
Published: May 2023

Kuta Tinggi Village, Badar District, Southeast Aceh Regency is a village whose people still maintain and uphold customs and religion highly. Every time there is an event, they still carry out the Customs. Like the Pangeri tradition (plain flour) where this tradition is still carried out at weddings and apostle circumcision. Especially during weddings for the bride, some carry out the Pangeri tradition by violating Islamic law, such as not wearing the headscarf and shaking hands with those who are not mahrams, but it can be underlined that most people are still unfamiliar with such things, for those who understand religion it is impossible not to wearing headscarves etc. so that the writer is interested in researching the views of community leaders and religious scholars on the Pangeri Tradition in terms of the study of religions. The research method used by the author is a qualitative method of the Field Research type with the Phenomenology of Religion approach using symbolic interaction theory. Sources of data generated by the author is from the results of interviews, observation and documentation. The results of the study show that the views of the community and religious scholars towards the Pangeri tradition are well done and there are no harm as long as we do it the right way and do not violate Islamic law.
Does Inferior Oblique Muscle Overaction Affect Ocular Vestibular Evoked Myogenic Potentials?
Authors: Demir İsmail , Yalcin Muhammed Zeki , Cengiz Deniz Uğur , Aydın Şükrü , Çankaya Cem , Tekin Ahmet Mahmut
Published: May 2023

Objectives: Inferior oblique muscle overaction (IOOA) is a common ocular motility disorder. Ocular Vestibular Evoked Myogenic Potentials (oVEMP) are tests that evaluate the reflex pathway between the utricular macula and the inferior oblique muscle to detect vestibular diseases. Our study is of great importance as it is the first study in the literature to evaluate the effect of inferior oblique muscle overaction on oVEMP parameters. 
Methods: Thirty-five patients with unilateral inferior oblique muscle overaction (IOOA group) and 18 healthy volunteers without any neurological or vestibulocochlear disease were included in this study. All patients and healthy volunteers were evaluated with oVEMP.
Results: No statistically significant difference was found between the n1 latency, p1 latency, n1-p1 latency measurement values of the participants included in the study (p>0,05). A statistically significant difference was found between the n1-p1 amplitude measurement values of the participants in patient groups (non-squint eyes, squint eyes) and control groups (p-value was 0.038).
Conclusion: In IOOA patients, vestibulo-ocular reflex pathway may be affected, vestibular symptoms may develop thus o-VEMP responses may be affected. A careful anamnesis should be taken in IOOA patients, and it should be kept in mind that n1-p1 amplitudes and asymmetries may be significantly higher when o-VEMP is performed
Keywords: o-VEMP, Strabismus, Inferior oblique muscle overaction, Balance, Vertigo
The Relationship between Rejection Sensitivity and Social Anxiety among College Students in Rahim Yar Khan District
Authors: Muhammad Athar Hussain  , Shanza Rafaqat  , Humza Imran  , Sehrish Hussain
Published: May 2023

The educational study aims to find out the relationship between Rejection Sensitivity and Social Anxiety among College Students in Rahim Yar Khan District. In this research paper, challenges faced by teachers and students in finding and resolving the issues regarding social anxiety and rejection sensitivity will be discussed. The major objectives of the study were to identify the role of rejection and anxiety in academic achievement and investigate the relationship between factors influencing rejection and social anxiety among students and their effects on students’ performance. The population of the study consisted of all the girls’ and boys’ government colleges of district RYK. The total sample of the study was 500 students (180 boys and 320 girls). To achieve the objectives, two self-constructed questionnaires were used as a research tool with four Likert-type scales. The collected data were tabulated and analyzed by SPSS by using statistical measures such as percentage, frequency, mean, and std. deviation. Results declared that there is a significant and positive relationship between fear of rejection and social anxiety. A correlation test was applied to demonstrate the relationship between gender and rejection scale and its significance between factors. The main cause of anxiety is because of social setup. The addition of social exposure for students in the education period anxiety decrees and feelings of social acceptance increase. It will be helpful for the teachers to understand the social anxiety in students and tackle them according to the situation in a better way.
Inhibitory effect of herbal compounds on the Oxygen-insensitive NADPH nitro reductase enzyme of metronidazole-resistant Helicobacter pylori
Authors: Saeed Mohammadreza , Eghdami Anoosh
Published: May 2023

Helicobacter pylori is a significant risk factor for chronic gastritis, gastric ulcers, and gastric cancer. The purpose of this article is to investigate the potential impact of fifty herbal compounds derived from Ginger and Parsley plants, known for their antibacterial properties on the Oxygen-insensitive NADPH nitro reductase enzyme of metronidazole-resistant H. pylori. In the present study, the information on the structure of compounds, the H. pylori resistant to metronidazole enzyme, myristicin, and shogaol derivatives were obtained from databases such as ZINC15, RCSB (Protein Data Bank), and PubChem, respectively. Finally, molecular docking was performed with iGemdock2.1 and Molegro Virtual Docker. After molecular docking, four out of the fifty phytocompounds showed the lowest energy and the highest number of interactions with the amino acids at the binding sites. Among these four phytocompounds, the best phytocompound was N-Vanillyloctanamide derived from Ginger. Our molecular docking study suggests that ginger can be introduced as a potential candidate to inhibit the growth of H. pylori.
Pengaruh Internal Locus of Control Dan Dukungan Sosial Terhadap Career Adaptability Mahasiswa Tingkat Akhir Di Universitas ‘Aisyiyah Yogyakarta
Authors: Musoli Musoli , Rosita Ningsih Mutmainah
Published: May 2023

Career adaptability adalah kemampuan individu dalam beradaptasi dan mempersiapkan diri terhadap perubahan- perubahan yang akan terjadi pada situasi yang tak terprediksi pada kariernya kedepan dan pada lingkungan kerjanya. Penelitian ini ingin mengetahui apakah internal locus of control, dan dukungan sosial berpengaruh secara parsial terhadap career adaptability, dan juga ingin mengetahui apakah internal locus of control, dan dukungan sosial secara simultan berpengaruh terhadap career adaptability. Desain penelitian menggunakan metode deskriptif dengan pendekatan kuantitatif. Berdasarkan teknik purposive sampling, unit analisis dalam penelitian ini adalah Mahasiswa aktif tingkat akhir Universitas ‘Aisyiyah Yogyakarta yang sedang melakukan tugas akhir. Total responden dalam penelitian ini adalah 102 responden. Data yang ada kemudian dianalisa menggunakan aplikasi SPSS 20. Hasil penelitian menunjukkan beberapa temuan yaitu secara parsial internal locus of control dan dukungan sosial berpengaruh positif dan signifikan terhadap career adaptability mahasiswa, sedangkan secara simultan internal locus of control dan dukungan sosial berpengaruh positif dan signifikan terhadap career adaptability Mahasiswa aktif tingkat akhir Universitas ‘Aisyiyah Yogyakarta.
Faktor Pendorong Dan Pengahmbat Kampung Ramah Anak Di Kota Yogyakarta
Authors: Sugiyanto Sugiyanto , Kasmorejo Nyadi
Published: May 2023

Anak adalah anugerah dan amanah Allah SWT kepada orang tua dan lingkungan, sehingga anak harus dijaga dan diasuh dengan sebaik-baiknya agar mereka dapat tumbuh dan berkembang dengan baik dalam lingkungan yang aman dan stabil serta suasana yang bahagia, penuh kasih saying. Disisi lain setiap anak sebagai generasi penerus bangsa dan investasi masa depan bagi negara. Atas dasar itu anak tidak saja menjadi tanggungjawab orang tua, tetapi lingkungan dan negara turut bertanggungjawab atas keselamatan setiap anak. Penelitian ini mengunakann pendekatan kualitatif eksploratif, data dikumpulkan dengan teknik observasi, interview dan studi dokumentasi. Data primer dan sekunder divalidasi serta diintegrasikan dalam konten analisis serta dianalisis dengan alat analisis SWOT. Informane ditentukan secara propursif sampling.  Hasil penelitian menunjukan faktor pendorong karena kemandirian pendanaan dari warga setempat, kinerja, semangat dan komitmen pengurusyang baik serta support eksternal. Faktor penghambat tampak pada KRA kurang aktif ditandai dengan hidden action dan hidden information pengurus dan partisipasi lingkungan rendah.
Konsiliasi Pemerintah terhadap Program Jaringan Pengaman Sosial Provinsi Jambi
Authors: Efendi Ghina , Effendi Nahdah Khoirunnisa
Published: May 2023

Turunnya pemenuhan kebetuhan hidup dan penurunan ekonomi bagi masyarakat Indonesia, pemerintah membuat program dana bantuan sosial khusus untuk masyarakat terdampak corona viruse disase 19 terutama yang difokuskannya pada Jurnal ini adalah di Provinsi Jambi, selama masa pandemi COVID-19 ini penyaluran dana bansos akan dibantu oleh pemerintah melalui program Jaring Pengaman Sosial (JPS). Program ini dirancang oleh pemerintah untuk membantu masyarakat yang terkena dampak Corona Viruse Disase 19 di sebelas Kabupaten di Provinsi Jambi. Tujuan penelitian ini untuk melihat bagaimana penyaluran dana Jaring Pengaman Sosial (JPS) di sebelas kabupaten provinsi Jambi. Fokus penelitian ini pada transparasi, tanggung jawab, serta ketepatan pemerintah dalam penyaluran. Metode yang di gunakan pada penilitan ini adalah pendekatan kualitatif yaitu dengan menekankan interprestasi hasil dari analisis bagaimana pemerintah provinsi Jambi menerapkan Clean Goverment dalam melakukan konsiliasi dalam program Jaring Pengaman Sosial (JPS) yakni transparasi dana, ketepatan serta tanggung jawab. Teknik pengumpulan data pada penelitian ini menggunakan cara melihat berita, website, jurnal dan artikel. Teknik analisis data dalam penelitian ini akan dilihat dari tiga indikator yaitu ketepatan, tanggung jawab, serta transparasi pemerintah dalam program Jaring Pengaman Sosial. Hasil Penelitian menunjukan bahwa pemerintah telah menyalurkan dana bansos melalui program Jaring Pengaman Sosial (JPS) di sebelas kabupaten di Provinsi Jambi yang mana pada program ini pun memiliki kekuranggan dan yang bisa mendapatkan atau mendaftar program ini adalah orang yang sedang tidak mendapatkan bantuan sosial laninnya dan setiap yang mendaftar akan diseleksi, orang yang lulus selesksi akan mendapatkan bantuan berupa sembako yang senilai Rp 350.000 dan uang tunai sebesar Rp 250.000.
Peran Profetik Media Sosial dalam Mengadvokasi Keadilan Sosial
Authors: Agus Triono Tomi , Candra Sangaji Reno
Published: May 2023

Media sosial telah menjadi alat yang semakin penting untuk komunikasi dan aktivisme dalam beberapa tahun terakhir. Makalah ini mengeksplorasi peran kenabian media sosial dalam mengadvokasi keadilan sosial dan mengkaji cara individu dan organisasi menggunakan media sosial untuk meningkatkan kesadaran tentang masalah sosial dan untuk mempromosikan perubahan positif. Makalah ini juga membahas tantangan dan keterbatasan media sosial sebagai alat advokasi sosial dan berpendapat untuk terus menggunakan media sosial sebagai sarana mempromosikan keadilan sosial. Makalah ini menggunakan design literatur review dengan pengambilan data dari jurnal bereputasi dan analisis tematik terhadap literatur yang dikumpulkan untuk memahami peran prophetic media sosial dalam mengadvokasi keadilan sosial. Peran prophetic media sosial dalam mengadvokasi keadilan sosial adalah kekuatan yang signifikan, dari mengadvokasi hak asasi manusia hingga mempromosikan kesetaraan, media sosial telah menjadi alat yang berharga untuk mempromosikan perubahan positif dan meningkatkan kesadaran tentang isu-isu sosial yang penting. Namun, tantangan dan keterbatasan media sosial sebagai alat advokasi sosial tidak dapat diabaikan, dan penting untuk melanjutkan keterlibatan dan aktivisme melalui penggunaan media sosial.
Implementasi Kepemimpinan Profetik Dalam Memecahkan Masalah Sosial Di Indonesia: Study Literatur Profetik Leadership
Authors: Candra Sangaji Reno , Agus Triono Tomi
Published: May 2023

Indonesia sebagai negara besar dengan jumlah penduduk yang sangat banyak, mengalami berbagai masalah sosial yang tidak mudah untuk diselesaikan. Berbagai masalah sosial seperti korupsi, diskriminasi, kemiskinan, dan permasalahan lingkungan hidup sangat mempengaruhi kualitas hidup masyarakat Indonesia. Dalam situasi ini, kepemimpinan merupakan salah satu hal yang penting untuk memecahkan masalah sosial yang ada. Kepemimpinan profetik merupakan salah satu jenis kepemimpinan yang dapat memecahkan masalah sosial dengan baik. secara umum, kepemimpinan profetik memiliki potensi untuk membantu dalam mengatasi masalah sosial melalui fokus pada nilai-nilai moral dan etika yang tinggi, serta kemampuan untuk memotivasi dan memimpin orang untuk bertindak dalam kepentingan masyarakat.
SAĞLIK SEKTÖRÜNDE ÇALIŞANLARIN SENDİKAL BAĞLILIĞINA YÖNELİK BİR ALAN ARAŞTIRMASI
Authors: ŞAFAK Kerem , YEŞİLTAŞ Aysun , ŞAFAK Şadiye
Published: May 2023

Araştırmanın amacı, sendikaya üyesi sağlık çalışanlarının sendikaya bağlılık düzeylerinin ve bu bağlılığı etkileyen faktörlerin belirlenmesidir. Bu araştırma Konya ilindeki bir memur sendikasına üye 320 sağlık çalışanıyla yürütülmüş tanımlayıcı bir çalışmadır. Çalışmada veri toplama aracı olarak “Sendikaya Bağlılık Ölçeği” ve demografik soruları içeren anket formu kullanılmıştır. Araştırmada katılımcılarının %56,5’i sendika aidatını kendisi ödese bile sendikaya üye olacağını; %38,8’i sendikal faaliyetlere katıldığını; %51,4’ü sendikanın kurumda yükselmede ve %50,9’u sendikanın tayin konusunda etkili olduğunu belirtmiştir. Ayrıca katılımcıların %39,6’sı sendikanın, üyelerinin sorunlarını çözme konusunda ve %45,6’sı sendikanın toplu görüşmelerde etkili olmadığını ifade etmiştir. Sendikaya bağlılık alt boyutları ile medeni durum, çalışma yılı, ilk sendikası olma ve eğitim açısından anlamlı farklılık tespit edilememiştir. Sonuç olarak erkek katılımcıların ve idari hizmetlerde çalışanların sendikaya bağlılık düzeyinin yüksek olduğu görülmüştür. Sendikaya üyelik süresi ve yaş arttıkça da sendikaya bağlılığın arttığı tespit edilmiştir. Sendikalar, üyelerinin sendikalarına karşı olan güvenini artırmak için çaba sarf etmelidirler.
Stages of Indoctrination and a Pathway into terrorism: A perspective from Bangladesh
Authors: Iqbal Sumaiya , Rahman Zia
Published: May 2023

In a time and age of identities, violent extremism fueled by identity-based ideology comes as no surprise. Terrorist attacks from numerous groups take place globally, and Bangladesh has also encountered decades of terrorist violence since its independence particularly from groups that include Jamaat Ul-Mujahideen Bangladesh, Harkat Ul-Jihad Al-Islami Bangladesh, among others. An aspect that requires deeper understanding is the process of how individuals make their way into terrorist organizations. This paper examines the stages of indoctrination experienced by individuals who were recruited into Bangladeshi terrorist outfits. . The research was conducted with grounded theory methodology, using the bottom to up inductive process, for construction of an explanatory framework. Primary data was collected from in depth semi-structured interviews of individuals who had been recruited into Bangladeshi terrorist outfits and law enforcement officials. Findings have identified stages of indoctrination inspired by Sageman’s model of radicalization (Sageman, 2007), Moghaddam’s Staircase to Terrorism (Moghaddam, 20017) and the New York Police Department’s four factors (NYPD, 2007).
Replacement Effect of Noug-Cake with Lablab Purpureus Seed on Biological Performance of Woyito-Guji Goat Fed a Basal Diet of Haricot Bean Haulms
Authors: Hidosa Denbela , Girma Mekete
Published: May 2023

Objective: This study aimed to investigate the replacement effect of noug-cake (NC) with lablab purpureus seed (LPS) on biological performance of Woyito-Guji goat. Material and Methods: About 24 intact male Woyito-Guji bucks having a preliminary weight of 17.34kg were allocated to one of the 4 investigational treatments in a randomized complete block design (RCBD). The investigational treatments used were; haricot bean haulms (HBH) ad-libitum+ 18% of wheat bran (WB)+23% of maize (MG)+24% of sorghum (SG)+20% of NC+12% of sunflower seed (SFS) +1.5% of common salt and+1.5% of limestone (T1), HBH ad-libitum+18% of WB+22% of MG + 20% of SG+15% of NC+12% of SFS + 10% of LPS+1.5% of common salt + 1.5% of limestone(T2), HBH ad-libitum+20% of WB +23% of MG + 22% of SG+ 5% of NC+12% of SFS + 15% of LPS +1.5% of common salt and+ 1.5% of limestone (T3), and HBH ad-libitum+18% of WB + 23% of MG + 24% of SG +12% of SFS+ 20% of LPS+1.5% of common salt + 1.5% of limestone (T4). Results: The total-dry-matter and crude protein consumption, and nutrient digestibility were higher (p<0.001) for bucks consumed the T1 and T4 over the bucks consumed the T2 and T3. Similarly, goats consumed T1 and T4 gained more (p<0.001) average-daily-gain (ADG), hot carcass weight (HCW), and rib eye muscle area (REMA) than bucks that given T2 and T3. Conclusion: The findings from this investigation pointed-out that replacing NC with roasted LPS at a 20% inclusion level in goat rations improved biological performance of goat.
NFTKART - A NFT Market place
Authors:   Undergraduate Students, Information Technology Department, Institute of Technology and Management GIDA Gorakhpur, Uttar Pradesh, India., Sharma Aman , Sahani Ajay , Singh Rahul Ranjan , Maddhesiya Sachin
Published: May 2023

A non-fungible token (NFT) is a new kind of blockchain-based token that is unique and indivisible. They were first introduced in late 2017. Fungible tokens have pioneered new use cases such as initial coin offerings, but the value of his NFTs as a component is still unknown. This study fills a gap in theoretical and practical knowledge by demonstrating the effectiveness of NFTs in the event ticketing arena. Using a rigorous design science research approach, we design, build, and extensively evaluate a prototype event ticket system based on NFTs. As a result, we demonstrate how NFTs can be used to tokenize digital products, reduce fraud, and increase control over secondary market transactions. We also provide generalizable information on the benefits and challenges of NFTs and their implications for researchers and practitioners. Key Word :NFTs, Blockchain, Polygon Testnet, Hardhat, Ethereum, NextJS, IPFS
Smart Brain Tumor Prediction System
Authors:   Information Technology, JSPM’s Jayawantrao Sawant College of Engineering, Pune, India., Kalunge Vishwas , Gaddhane Ashish , Abutalha Ansari , Pawar Aakash , Pathan Ibrahimkhan , Bhalsing Jayesh
Published: May 2023

Brain is the regulatory unit in human body. It controls the functions such as memory, vision, hearing, knowledge, personality, problem solving, etc. The main reason for brain tumor is the abandoned progress of brain cells. Many health organizations have recognized brain tumor as the second foremost dispute that causes many human deaths all around the world. Identification of brain tumor at a premature stage offers opportunity of effective medical treatment. Use of Magnetic Resonance Imaging images have been recognized as more detailed and more consistent images when compared to Computed Tomography images. In this project we are predicting the brain tumor using machine learning algorithms. there are various techniques to detect brain tumor or neoplasms. The most competent and effective algorithm that we will be using in this project is CNN (Convolutional Neural Network).It is a Deep Learning Algorithm that is Used for Image Processing Starting with Pre-processing brain images then, segmenting them, feature extraction of unwanted noisy and blurry part, clustering and detection of the tumor are the methodologies of our Project. Key Word: Brain Tumor Prediction, MRI Images, CNN, Image Processing and Deep Learning.
Plantas acuáticas para el tratamiento de agua en espejos ornamentales
Authors: González Josefina , Santana Damarys , Quintas Patricio
Published: May 2023

En el presente trabajo se analiza el uso de las plantas acuáticas para purificar el agua de los espejos ornamentales en el Parque de La Juventud de la Universidad deMatanzas, Cuba. El estudio se realizó a escala de laboratorio y se valoraron la determinación de parámetros como: oxígeno disuelto, demanda química y bioquímica de oxígeno, pH, dureza total, sólidos totales, coliformes fecales y  cloruro. Se comprobó que las plantas acuáticas pueden disminuir los valores de los indicadores de calidad del agua a niveles que permitan disminuir la frecuencia con que se cambia el agua de los espejos. Se analizó la reutilización del agua tratada en los espejos en el riego de las plantas ornamentales del parque. Los resultados evidencian que el uso de las plantas acuáticas flotantes Nymphaea ampla y Eichornia crassipes constituye una alternativa para tratar las aguas y mejorar su calidad con un efecto económico considerable por concepto de ahorro de agua potable.
Elaboración de curvas de Intensidad Frecuencia y Duración (IFD) para la estimación de sequías en empresas agrícolas
Authors: Brown Manrique Oscar Nemesio , Gallardo Ballat Yurisbel , Pérez W
Published: May 2023

La presente investigación analiza la elaboración de las curvas de sequía Intensidad Frecuencia Duración (IFD) en el área que comprende la Empresa de Cultivos Varios Juventud Heroica, situada en el municipio Venezuela de la provincia Ciego de Ávila, a partir del análisis de la precipitación medida en áreas de la propia empresa durante un periodo de 28 años de observaciones sistemáticas. Los resultados demuestran que se logra una adecuada estimación de la intensidad máxima de la sequía en función de la duración, a través de modelos potenciales y polinomiales de segundo y tercer orden. Las ecuaciones de Talbot proporciona una acertada relación entre la intensidad máxima y la duración de la sequía para los periodos de 2, 7, 9, 14 y 28 años; sin embargo no logran resultados confiables en los periodos de 1 y 3 años. La ecuación de Aparicio establece de forma apropiada la relación funcional instantánea entre las tres variables de severidad analizadas, con un adecuado coeficiente de correlación. En general en todos los casos evaluados se garantiza una acertada estimación y pronóstico de la intensidad máxima de sequía en la localidad de estudio.