bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Elements on the Microstructure and Mechanical Properties of AlCoCrFeNiTi High-Entropy Alloys
Authors: Zhang Jingli , Xin Shewei , Zhang Yongqiang , Guo Ping , Sun Huamei , Li Ting , Qin Cheng
Published: January 2023

AlCoCrFeNiTi high-entropy alloys (HEAs) have attracted much attention because of their excellent mechanical properties. Here, we systemically studied the effects of elements on the microstructure and mechanical properties of AlCoCrFeNiTi HEAs. The results showed that the phase composition and morphology are significantly affected by the elements. With increasing Ti addition, the lattice parameters of the solid solution phase increased slightly, and lattice distortion occurred. Al changes the crystal structure of FCC to BCC and reduces the lattice distortion energy of the alloy. The BCC phase obviously increases with increasing Al content. However, excessive Al, Ti and Cr promote the formation of intermetallic compound phases, while Ni, Fe and Co promote the transformation of the alloy into a solid solution. The properties of AlCoCrFeNiTi HEAs are closely related to their phase composition and morphology. When HEAs consist only of FCC and BCC phases, their ductility and strength are greatly improved. The presence of an intermetallic compound phase in the microstructure can significantly reduce the configurational entropy of adjacent solid solutions, thus reducing the strengthening effect of solid solutions. Additionally, the AlCoCrFeNiTi HEAs with different microstructures show different deformation mechanisms. The deformation of FCC + BCC HEAs with cellular structures is uniform and presents great plasticity and strength. When the cellular-structure HEAs contain equiaxed BCC, thick lamellar BCC/FCC or intermetallic compound phases, cracks tend to occur and propagate along the phase boundary due to the local nonuniform deformation. For AlCoCrFeNiTi HEAs with dendrite structures, after initiation at the phase boundary, the crack does not easily spread to the dendrite FCC phase but causes the interdendritic BCC phase to crack.
Investigation of Chemical Composition and Biological Activities of Ajuga pyramidalis—Isolation of Iridoids and Phenylethanoid Glycosides
Authors: Gori Anthonin , Boucherle Benjamin , Rey Aurélien , Rome Maxime , Barette Caroline , Soleilhac Emmanuelle , Philouze Christian , Fauvarque Marie-Odile , Fuzzati Nicola , Peuchmaur Marine
Published: January 2023

Despite several studies on the Ajuga L. genus, the chemical composition of Ajuga pyramidalis, an alpine endemic species, is still largely unknown. The purpose of this study was to therefore deeper describe it, particularly from the phytochemistry and bioactivity perspectives. In that respect, A. pyramidalis was investigated and 95% of the extracted mass of the plant was characterized by chromatography and mass spectrometry. Apart from the already determined chemical compounds, namely, harpagide and 8-O-acetylharpagide, two iridoids, and neoajugapyrin A, a neo-clerodane diterpene, and three polyphenols (echinacoside, verbascoside and teupoloside) were identified for the first time in A. pyramidalis. Incidentally, the first RX structure of a harpagoside derivative is also described in this paper. The extracts and isolated compounds were then evaluated for various biochemical or biological activities; notably a targeted action on the renewal of the epidermis was highlighted with potential applications in the cosmetic field for anti-aging.
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
Authors: Mukherjee Anirban Goutam , Wanjari Uddesh Ramesh , Kannampuzha Sandra , Murali Reshma , Namachivayam Arunraj , Ganesan Raja , Dey Abhijit , Babu Achsha , Renu Kaviyarasi , Vellingiri Balachandar , Ramanathan Gnanasambandan , Priya Doss C. George , Elsherbiny Nehal , Elsherbini Amira M. , Alsamman Alsamman M. , Zayed Hatem , Gopalakrishnan Abilash Valsala
Published: January 2023

As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it.
Comparison of the Pig Breeds in the Small Intestinal Morphology and Digestive Functions at Different Ages
Authors: Cheng Yating , Ding Sujuan , Azad Md. Abul Kalam , Song Bo , Kong Xiangfeng
Published: January 2023

The small intestine is the main site for digestion and absorption of nutrients, and the development of the small intestine can be affected by several factors, such as diet composition, age, and genotype. Thus, this study aimed to compare the small intestinal morphology and digestive function differences at different ages of three pig breeds. Thirty litters of newborn Taoyuan black (TB), Xiangcun black (XB), and Duroc (DR) piglets (ten litters per breed) were selected for this study. Ten piglets from each breed were selected and sampled at 1, 10, 21, and 24 days old. The results showed that the TB and XB piglets had lower growth but had higher lactase and maltase activities in the jejunum compared with the DR piglets, while most of the digestive enzyme activities in the ileum were higher in the DR piglets at different ages. The expression levels of nutrient transporters, mainly including amino acids, glucose, and fatty acids transporters, differed in the jejunum at different ages among three pig breeds and were higher in the DR piglets at 1 day old and XB piglets at 24 days old. Collectively, these findings suggest that the phenotypic differences in the growth, intestinal morphology, and digestive function among the three pig breeds mainly resulted from the differences in digestive enzymes and nutrient transporters in the intestine.
One-Dimensional Phononic Crystals: A Simplified Platform for Effective Detection of Heavy Metals in Water with High Sensitivity
Authors: Almawgani Abdulkarem H. M. , Fathy Hamza Makhlouf , Ali Ghassan Ahmed , Elsayed Hussein A. , Mehaney Ahmed
Published: January 2023

Recently, the pollution of fresh water with heavy metals due to technological and industrial breakthroughs has reached record levels. Therefore, monitoring these metals in fresh water has become essentially urgent. Meanwhile, the conventional periodic one-dimensional phononic crystals can provide a novel platform for detecting the pollution of heavy metals in fresh water with high sensitivity. A simplified design of a defective, one-dimensional phononic crystals (1D-PnC) structure is introduced in this paper. The sensor is designed from a lead-epoxy multilayer with a central defect layer filled with an aqueous solution from cadmium bromide (CdBr2). The formation of a resonant peak through the transmittance spectrum is highly expected. This study primarily aims to monitor and detect the concentration of cadmium bromide in pure water based on shifting the position of this resonant peak. Notably, any change in cadmium bromide concentration can affect the acoustic properties of cadmium bromide directly. The transfer matrix method has been used to calculate the transmission spectra of the incident acoustic wave. The numerical findings are mainly based on the optimization of the cadmium bromide layer thickness, lead layer thickness, epoxy layer thickness, and the number of periods to investigate the most optimum sensor performance. The introduced sensor in this study has provided a remarkably high sensitivity (S = 1904.25 Hz) within a concentration range of (0–10,000 ppm). The proposed sensor provides a quality factor (QF), a resolution, and a figure of merit of 1398.51752, 48,875,750 Hz, and 4.12088 × 10−5 (/ppm), respectively. Accordingly, this sensor can be a potentially robust base for a promising platform to detect small concentrations of heavy metal ions in fresh water.
Origami-Type Flexible Thermoelectric Generator Fabricated by Self-Folding
Authors: Sato Yusuke , Terashima Shingo , Iwase Eiji
Published: January 2023

The flexibility of thermoelectric generators (TEGs) is important for low-contact thermal resistance to curved heat sources. However, approaches that depend on soft materials, which are used in most existing studies, have the problem of low performance in terms of the substrate’s thermal conductivity and the thermoelectric conversion efficiency of the thermoelectric (TE) elements. In this study, we propose a method to fabricate “Origami-TEG”, a TEG with an origami structure that enables both flexibility and the usage of high-performance rigid materials by self-folding. By applying the principle of the linkage mechanism to self-folding, we realized a fabrication process in which the TE element-mounting process and the active-material-addition process were separated in time. The fabricated origami-TEG showed similar internal resistance and maximum output power when attached to heat sources with flat and curved surfaces. Furthermore, it exhibited high-performance stability against both stretching and bending deformations.
DC-Dielectrophoretic Manipulation and Isolation of Microplastic Particle-Treated Microalgae Cells in Asymmetric-Orifice-Based Microfluidic Chip
Authors: Gao Tianbo , Zhao Kai , Zhang Jiaqi , Zhang Kaihuan
Published: January 2023

A novel direct-current dielectrophoretic (DC–DEP) method is proposed for the manipulation and isolation of microplastic particle (MP)-treated microalgae cells according to their dielectric properties in a microfluidic chip. The lateral migration and trajectory of the microalgae cells were investigated. To induce stronger DC–DEP effects, a non-homogeneous electric-field gradient was generated by applying the DC electric voltages through triple pairs of asymmetric orifices with three small orifices and one large orifice located on the opposite microchannel wall across the whole channel, leading to the enhanced magnitude of the non-uniform electric-field gradient and effective dielectrophoretic area. The effects of the applied voltage, the polystyrene (PS) adsorption coverage, and thickness on the DC–DEP behaviors and migration were numerically investigated, and it was found that the effect of the PS adsorption thickness of the Chlorella cells on the DC–DEP behaviors can be neglected, but the effect on their trajectory shifts cannot. In this way, the separation of 3 µm and 6 µm Chlorella coated with 100% PS particles and the isolation of the Chlorella cells from those coated with various coverages and thicknesses of PS particles was successfully achieved, providing a promising method for the isolation of microalgae cells and the removal of undesired cells from a target suspension.
The Development of the Bacterial Community of Brown Trout (Salmo trutta) during Ontogeny
Authors: Keiz Katharina , Ulrich Sebastian , Wenderlein Jasmin , Keferloher Patrick , Wiesinger Anna , Neuhaus Klaus , Lagkouvardos Ilias , Wedekind Helmut , Straubinger Reinhard K.
Published: January 2023

Brown trout (Salmo trutta) is an important aquaculture species in Germany, but its production faces challenges due to global warming and a high embryo mortality. Climate factors might influence the fish’s bacterial community (BC) and thus increase embryo mortality. Yet, knowledge of the physiological BC during ontogeny in general is scarce. In this project, the BC of brown trout has been investigated in a period from unfertilized egg to 95 days post fertilization (dpf) using 16S rRNA gene amplicon sequencing. Developmental changes differed between early and late ontogeny and major differences in BC occurred especially during early developmental stages. Thus, analysis was conducted separately for 0 to 67 dpf and from 67 to 95 dpf. All analyzed stages were sampled in toto to avoid bias due to different sampling methods in different developmental stages. The most abundant phylum in the BC of all developmental stages was Pseudomonadota, while only two families (Comamonadaceae and Moraxellaceae) occurred in all developmental stages. The early developmental stages until 67 dpf displayed greater shifts in their BC regarding bacterial richness, microbial diversity, and taxonomic composition. Thereafter, in the fry stages, the BC seemed to stabilize and changes were moderate. In future studies, a reduction in the sampling time frames during early development, an increase in sampling numbers, and an attempt for biological reproduction in order to characterize the causes of these variations is recommended.
Interesting Halophilic Sulphur-Oxidising Bacteria with Bioleaching Potential: Implications for Pollutant Mobilisation from Mine Waste
Authors: Opara Chiamaka Belsonia , Kamariah Nor , Spooren Jeroen , Pollmann Katrin , Kutschke Sabine
Published: January 2023

For many years, research on the microbial-dissolution of metals from ores or waste materials mainly focussed on the study of acidophilic organisms. However, most acidophilic bioleaching microorganisms have limited tolerance to high chloride concentrations, thereby requiring fresh water for bioleaching operations. There is a growing interest in the use of seawater for leaching purposes, especially in regions with less access to fresh water. Consequently, there is a need to find halophilic organisms with bioleaching potentials. This study investigated the bioleaching potentials of four moderately halophilic sulphur-oxidising bacteria: Thiomicrospira cyclica, Thiohalobacter thiocyanaticus, Thioclava electrotropha and Thioclava pacifica. Results revealed T. electrotropha and T. pacifica as the most promising for bioleaching. Pure cultures of the two Thioclava strains liberated about 30% Co, and between 8–17% Cu, Pb, Zn, K, Cd, and Mn from a mine waste rock sample from the Neves Corvo mine, Portugal. Microwave roasting of the waste rock at 400 and 500 °C improved the bioleaching efficiency of T. electrotropha for Pb (13.7 to 45.7%), Ag (5.3 to 36%) and In (0 to 27.4%). Mineralogical analysis of the bioleached residues using SEM/MLA-GXMAP showed no major difference in the mineral compositions before or after bioleaching by the Thioclava spp. Generally, the bioleaching rates of the Thioclava spp. are quite low compared to that of the conventional acidophilic bioleaching bacteria. Nevertheless, their ability to liberate potential pollutants (metal(loid)s) into solution from mine waste raises environmental concerns. This is due to their relevance in the biogeochemistry of mine waste dumps, as similar neutrophile halophilic sulphur-oxidising organisms (e.g., Halothiobacillus spp.) have been isolated from mine wastes. On the other hand, the use of competent halophilic microorganisms could be the future of bioleaching due to their high tolerance to Cl- ions and their potential to catalyse mineral dissolution in seawater media, instead of fresh water.
Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2
Authors: Cennamo Michele , La Civita Evelina , Sarno Laura , Carbone Gianluigi , Di Somma Sarah , Cabaro Serena , Troisi Jacopo , Sirico Angelo , Improda Francesco Paolo , Guida Maurizio , Terracciano Daniela , Portella Giuseppe
Published: January 2023

COVID-19 is characterized by the immune system’s overreaction resulting in a ‘cytokine storm’, consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers.
Occurrence Relationship between Sodium and Maceral Groups in Subbituminous Coal: A Case Study on Zhundong Coal and Shenfu Coal
Authors: He Xin , Wang Wenfeng , Yang Yitao , Zhou Changchun , He Jingfeng , Duan Piaopiao , Lu Qingfeng
Published: January 2023

The occurrence characteristics of sodium and its potential relationship with macerals in Zhundong coal, as well as in Shenfu coal with average sodium levels, are investigated in this study. A new five-step sequential extraction method was first conducted for determination. The occurrence status of sodium and its related macerals in samples was determined by microscope and SEM–EDS (scanning electron microscope–energy dispersive X-ray spectroscopy). Soluble sodium salts (H2O-Na) make up the primary proportion of sodium in Zhundong coal, at approximately 50%, while various sodium species are distributed in Shenfu coal with nonobvious differences. Inertinite contains more sodium than vitrinite does in both coals, and the highest enrichment degree of sodium was discovered in inertinite from Zhundong coal, which presented primarily as NaCl crystals (H2O-Na) in fusinite cells, with a local weight percentage of over 15%. More specifically, H2O-Na and insoluble Na both tend to enrich in fusinite. Additionally, it is found that maceral-rich products can be gathered using triboelectrostatic separation, and a portion of sodium can thus be removed from the coal by removing inertinite. This study may provide new insights and references regarding sodium removal from Zhundong coal.
Synthesis of Nanocrystalline PuO2 by Hydrothermal and Thermal Decomposition of Pu(IV) Oxalate: A Comparative Study
Authors: Baumann Viktoria , Popa Karin , Walter Olaf , Rivenet Murielle , Senentz Gérald , Morel Bertrand , Konings Rudy J.M.
Published: January 2023

In recent years, the hydrothermal conversion of actinide (IV) oxalates into nanometric actinide dioxides (AnO2) has begun to be investigated as an alternative to the widely implemented thermal decomposition method. We present here a comparison between the hydrothermal and the conventional thermal decomposition of Pu(IV) oxalate in terms of particle size, morphology and residual carbon content. A parametric study was carried out in order to define the temperature and time applied in the hydrothermal conversion of tetravalent Pu-oxalate into PuO2 and to optimize the reaction conditions.
Mechanisms of Individual and Simultaneous Adsorption of Antibiotics and Dyes onto Halloysite Nanoclay and Regeneration of Saturated Adsorbent via Cold Plasma Bubbling
Authors: Giannoulia Stefania , Triantaphyllidou Irene-Eva , Tekerlekopoulou Athanasia G. , Aggelopoulos Christos A.
Published: January 2023

Halloysite nanoclay (HNC) was examined as an adsorbent for the individual and simultaneous removal of antibiotic enrofloxacin (ENRO) and methylene blue (MB) from aqueous solutions, alongside its regeneration via cold atmospheric plasma (CAP) bubbling. Initially, batch kinetics and isotherm studies were carried out, while the effect of several parameters was evaluated. Both ENRO and MB adsorption onto HNC was better described by Langmuir model, with its maximum adsorption capacity being 34.80 and 27.66 mg/g, respectively. A Pseudo-second order model fitted the experimental data satisfactorily, suggesting chemisorption (through electrostatic interactions) as the prevailing adsorption mechanism, whereas adsorption was also controlled by film diffusion. In the binary system, the presence of MB seemed to act antagonistically to the adsorption of ENRO. The saturated adsorbent was regenerated inside a CAP microbubble reactor and its adsorption capacity was re-tested by applying new adsorption cycles. CAP bubbling was able to efficiently regenerate saturated HNC with low energy requirements (16.67 Wh/g-adsorbent) in contrast to Fenton oxidation. Most importantly, the enhanced adsorption capacity of the CAP-regenerated HNC (compared to raw HNC), when applied in new adsorption cycles, indicated its activation during the regeneration process. The present study provides a green, sustainable and highly effective alternative for water remediation where pharmaceutical and dyes co-exist.
MXene-Carbon Nanotube Composites: Properties and Applications
Authors: Mohajer Fatemeh , Ziarani Ghodsi Mohammadi , Badiei Alireza , Iravani Siavash , Varma Rajender S.
Published: January 2023

Today, MXenes and their composites have shown attractive capabilities in numerous fields of electronics, co-catalysis/photocatalysis, sensing/imaging, batteries/supercapacitors, electromagnetic interference (EMI) shielding, tissue engineering/regenerative medicine, drug delivery, cancer theranostics, and soft robotics. In this aspect, MXene-carbon nanotube (CNT) composites have been widely constructed with improved environmental stability, excellent electrical conductivity, and robust mechanical properties, providing great opportunities for designing modern and intelligent systems with diagnostic/therapeutic, electronic, and environmental applications. MXenes with unique architectures, large specific surface areas, ease of functionalization, and high electrical conductivity have been employed for hybridization with CNTs with superb heat conductivity, electrical conductivity, and fascinating mechanical features. However, most of the studies have centered around their electronic, EMI shielding, catalytic, and sensing applications; thus, the need for research on biomedical and diagnostic/therapeutic applications of these materials ought to be given more attention. The photothermal conversion efficiency, selectivity/sensitivity, environmental stability/recyclability, biocompatibility/toxicity, long-term biosafety, stimuli-responsiveness features, and clinical translation studies are among the most crucial research aspects that still need to be comprehensively investigated. Although limited explorations have focused on MXene-CNT composites, future studies should be planned on the optimization of reaction/synthesis conditions, surface functionalization, and toxicological evaluations. Herein, most recent advancements pertaining to the applications of MXene-CNT composites in sensing, catalysis, supercapacitors/batteries, EMI shielding, water treatment/pollutants removal are highlighted, focusing on current trends, challenges, and future outlooks.
Water-Soluble Pd Nanoparticles for the Anti-Markovnikov Oxidation of Allyl Benzene in Water
Authors: Avila Edwin , Nixarlidis Christos , Shon Young-Seok
Published: January 2023

The catalytic activity and selectivity of two different water-soluble palladium nanoparticles capped with 5-(trimethylammonio)pentanethiolate and 6-(carboxylate)hexanethiolate ligands are investigated using the catalytic reaction of allyl benzene. The results show that the regioselective transformation of allyl benzene to 3-phenylpropanal occurs at room temperature and under atmospheric pressure in neat water via a Tsuji–Wacker type oxidation. Conventionally, the Tsuji–Wacker oxidation promotes the Markovnikov oxidation of terminal alkenes to their respective ketones in the presence of dioxygen. Water-soluble Pd nanoparticles, however, catalyze the anti-Markovnikov oxidation of allyl benzene to 3-phenylpropanal in up to 83% yields. Catalytic results of other aromatic alkenes suggest that the presence of benzylic hydrogen is a key to the formation of a p-allyl Pd intermediate and the anti-Markovnikov addition of H2O. The subsequent b-H elimination and tautomerization contribute to the formation of aldehyde products. Water-soluble Pd nanoparticles are characterized using nuclear magnetic resonance (NMR), UV–vis spectroscopy, thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). Catalysis results are examined using 1H NMR and/or GC-MS analyses of isolated reaction mixtures.
Synthesis and Deposition of Silver Nanowires on Porous Silicon as an Ultraviolet Light Photodetector
Authors: Alqanoo Anas A. M. , Ahmed Naser M. , Hashim Md. R. , Almessiere Munirah A. , Taya Sofyan A. , Alsadig Ahmed , Aldaghri Osamah A. , Ibnaouf Khalid Hassan
Published: January 2023

The applications of silver nanowires (AgNWs) are clearly relevant to their purity and morphology. Therefore, the synthesis parameters should be precisely adjusted in order to obtain AgNWs with a high aspect ratio. Consequently, controlling the reaction time versus the reaction temperature of the AgNWs is crucial to synthesize AgNWs with a high crystallinity and is important in fabricating optoelectronic devices. In this work, we tracked the morphological alterations of AgNWs during the growth process in order to determine the optimal reaction time and temperature. Thus, here, the UV–Vis absorption spectra were used to investigate how the reaction time varies with the temperature. The reaction was conducted at five different temperatures, 140–180 °C. As a result, an equation was developed to describe the relationship between them and to calculate the reaction time at any given reaction temperature. It was observed that the average diameter of the NWs was temperature-dependent and had a minimum value of 23 nm at a reaction temperature of 150 °C. A significant purification technique was conducted for the final product at a reaction temperature of 150 °C with two different speeds in the centrifuge to remove the heavy and light by-products. Based on these qualities, a AgNWs-based porous Si (AgNWs/P-Si) device was fabricated, and current-time pulsing was achieved using an ultra-violet (UV) irradiation of a 375 nm wavelength at four bias voltages of 1 V, 2 V, 3 V, and 4 V. We obtained a high level of sensitivity and detectivity with the values of 2247.49% and 2.89 × 1012 Jones, respectively. The photocurrent increased from the μA range in the P-Si to the mA range in the AgNWs/P-Si photodetector due to the featured surface plasmon resonance of the AgNWs compared to the other metals.
Highly Stable and Photoluminescent CsPbBr3/Cs4PbBr6 Composites for White-Light-Emitting Diodes and Visible Light Communication
Authors: Rao Longshi , Sun Bin , Liu Yang , Zhong Guisheng , Wen Mingfu , Zhang Jiayang , Fu Ting , Wang Shuangxi , Wang Fengtao , Niu Xiaodong
Published: January 2023

Inorganic lead halide perovskite is one of the most excellent fluorescent materials, and it plays an essential role in high-definition display and visible light communication (VLC). Its photochromic properties and stability determine the final performance of light-emitting devices. However, efficiently synthesizing perovskite with high quality and stability remains a significant challenge. Here, we develop a facile and environmentally friendly method for preparing high-stability and strong-emission CsPbBr3/Cs4PbBr6 composites using ultrasonication and liquid paraffin. Tuning the contents of liquid paraffin, bright-emission CsPbBr3/Cs4PbBr6 composite powders with a maximum PLQY of 74% were achieved. Thanks to the protection of the Cs4PbBr6 matrix and liquid paraffin, the photostability, thermostability, and polar solvent stability of CsPbBr3/Cs4PbBr6-LP are significantly improved compared to CsPbBr3 quantum dots and CsPbBr3/Cs4PbBr6 composites that were prepared without liquid paraffin. Moreover, the fabricated CsPbBr3/Cs4PbBr6-LP-based WLEDs show excellent luminescent performance with a power efficiency of 129.5 lm/W and a wide color gamut, with 121% of the NTSC and 94% of the Rec. 2020, demonstrating a promising candidate for displays. In addition, the CsPbBr3/Cs4PbBr6-LP-based WLEDs were also demonstrated in a VLC system. The results suggested the great potential of these high-performance WLEDs as an excitation light source to achieve VLC.
Manipulation of Photoelectrochemical Water Splitting by Controlling Direction of Carrier Movement Using InGaN/GaN Hetero-Structure Nanowires
Authors: Noh Siyun , Shin Jaehyeok , Yu Yeon-Tae , Ryu Mee-Yi , Kim Jin Soo
Published: January 2023

We report the improvement in photoelectrochemical water splitting (PEC-WS) by controlling migration kinetics of photo-generated carriers using InGaN/GaN hetero-structure nanowires (HSNWs) as a photocathode (PC) material. The InGaN/GaN HSNWs were formed by first growing GaN nanowires (NWs) on an Si substrate and then forming InGaN NWs thereon. The InGaN/GaN HSNWs can cause the accumulation of photo-generated carriers in InGaN due to the potential barrier formed at the hetero-interface between InGaN and GaN, to increase directional migration towards electrolyte rather than the Si substrate, and consequently to contribute more to the PEC-WS reaction with electrolyte. The PEC-WS using the InGaN/GaN-HSNW PC shows the current density of 12.6 mA/cm2 at −1 V versus reversible hydrogen electrode (RHE) and applied-bias photon-to-current conversion efficiency of 3.3% at −0.9 V versus RHE. The high-performance PEC-WS using the InGaN/GaN HSNWs can be explained by the increase in the reaction probability of carriers at the interface between InGaN NWs and electrolyte, which was analyzed by electrical resistance and capacitance values defined therein.
Nanomaterials for Catalysis and Energy Storage
Authors: Ansari Sajid Ali , Parveen Nazish , Rahman Md. Mahbubur
Published: January 2023

The development of nanomaterials with different shapes and sizes and which are utilized as effective materials for energy and environmental applications constitutes a challenge for researchers [...]
Efficacy of Elastodontic Devices vs. Clear Aligners in Lower Intercanine Distance Changes Assessed by Computer-Aided Evaluation
Authors: Ortu Eleonora , Pietropaoli Davide , Cova Samuele , Giannoni Mario , Monaco Annalisa
Published: January 2023

Background: This pilot study aimed to verify the efficacy of two orthodontic appliances in relation to changes in the lower intercanine distance in growing patients. Methods: Twenty patients aged 10–16 years were enrolled in the study and separated into test and control groups. The test group included 10 patients (5 males, 5 females; mean age, 10.4 ± 1.57 years) who were treated with an elastodontic device. The control group included 10 patients (5 males, 5 females; mean age 10.8 ± 1.53 years) who were treated with clear aligners. The two groups exhibited the same orthodontic features. The orthodontic criteria were: skeletal class I relationship, molar class I relationship, and presence of lower crowding. Patients were evaluated as having mild or moderate crowding according to the Daniels and Richmond index. The lower intercanine distance was evaluated at three timepoints via intraoral scans: T0 (before starting therapy), T1 (after six months), and T2 (after 1 year). Data were analyzed using a nonparametric approach via the Wilcoxon signed-rank test. Results: There was no statistically significant difference between the two groups at T0, T1, or T2 (p < 0.05). Conclusions: elastodontic devices and clear aligners can successfully help the orthodontist conduct lower arch expansion treatment. These appliances are comfortable to wear, simple to clean every day, and reduce the number of dentist appointments. Finally, but not of least importance, these devices have allowed dentists to continue orthodontic treatments during the lockdowns of the COVID-19 pandemic.
Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
Authors: Schmidt Christin , Schnierle Barbara S.
Published: January 2023

The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.
MAPK Cascade Signaling Is Involved in α-MMC Induced Growth Inhibition of Multiple Myeloma MM.1S Cells via G2 Arrest and Mitochondrial-Pathway-Dependent Apoptosis In Vitro
Authors: Cai Zi-Wei , Ye Ting , Jiang Pei-Wen , Liao Yu-Jiao , Wang Lin , Zhang Qing-Liang , Du Wen-Qian , Huang Min , Yang Ping , Li Min-Hui
Published: January 2023

Multiple myeloma is a hematological malignancy characterized by the unrestricted proliferation of plasma cells that secrete monoclonal immunoglobulins in the bone marrow. Alpha-momorcharin (α-MMC) is a type I ribosome-inactivating protein extracted from the seeds of the edible plant Momordica charantia L., which has a variety of biological activities. This study aimed to investigate the inhibitory effect of α-MMC on the proliferation of multiple myeloma MM.1S cells and the molecular mechanism of MM.1S cell death induced through the activation of cell signal transduction pathways. The cell counting kit-8 (CCK-8) assay was used to determine the inhibitory effect of α-MMC on the proliferation of MM.1S cells and its toxic effect on normal human peripheral blood mononuclear cells (PBMCs). The effect of α-MMC on the MM.1S cells’ morphology was observed via inverted microscope imaging. The effects of α-MMC on the MM.1S cell cycle, mitochondrial membrane potential (MMP), and apoptosis were explored using propidium iodide, JC-1, annexin V- fluorescein isothiocyanate/propidium iodide fluorescence staining, and flow cytometry (FCM) analysis. Western blot was used to detect the expressions levels of apoptosis-related proteins and MAPK-signaling-pathway-related proteins in MM.1S cells induced by α-MMC. The results of the CCK-8 showed that in the concentration range of no significant toxicity to PBMCs, α-MMC inhibited the proliferation of MM.1S cells in a time-dependent and concentration-dependent manner, and the IC50 value was 13.04 and 7.518 μg/mL for 24 and 48 h, respectively. Through inverted microscope imaging, it was observed that α-MMC induced a typical apoptotic morphology in MM.1S cells. The results of the FCM detection and analysis showed that α-MMC could arrest the MM.1S cells cycle at the G2 phase, decrease the MMP, and induce cell apoptosis. Western blot analysis found that α-MMC upregulated the expression levels of Bax, Bid, cleaved caspase-3, and cleaved PARP, and downregulated the expression levels of Mcl-1. At the same time, α-MMC decreased the expression levels of p-c-Raf, p-MEK1/2, p-ERK1/2, p-MSK1, and p-P90RSK, and increased the expression levels of p-p38, p-SPAK/JNK, p-c-Jun, and p-ATF2. The above results suggest that α-MMC can inhibit the proliferation of multiple myeloma MM.1S cells. MAPK cascade signaling is involved in the growth inhibition effect of α-MMC on MM.1S cells via cycle arrest and mitochondrial-pathway-dependent apoptosis.
Isolation, Detection and Analysis of Circulating Tumour Cells: A Nanotechnological Bioscope
Authors: Das Upama , Banik Soumyabrata , Nadumane Sharmila Sajankila , Chakrabarti Shweta , Gopal Dharshini , Kabekkodu Shama Prasada , Srisungsitthisunti Pornsak , Mazumder Nirmal , Biswas Rajib
Published: January 2023

Cancer is one of the dreaded diseases to which a sizeable proportion of the population succumbs every year. Despite the tremendous growth of the health sector, spanning diagnostics to treatment, early diagnosis is still in its infancy. In this regard, circulating tumour cells (CTCs) have of late grabbed the attention of researchers in the detection of metastasis and there has been a huge surge in the surrounding research activities. Acting as a biomarker, CTCs prove beneficial in a variety of aspects. Nanomaterial-based strategies have been devised to have a tremendous impact on the early and rapid examination of tumor cells. This review provides a panoramic overview of the different nanotechnological methodologies employed along with the pharmaceutical purview of cancer. Initiating from fundamentals, the recent nanotechnological developments toward the detection, isolation, and analysis of CTCs are comprehensively delineated. The review also includes state-of-the-art implementations of nanotechnological advances in the enumeration of CTCs, along with future challenges and recommendations thereof.
Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20
Authors: Nielsen Rasmus Blaaholm , Holm René , Pijpers Ils , Snoeys Jan , Nielsen Ulla Gro , Nielsen Carsten Uhd
Published: January 2023

P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms. Therefore, it was hypothesised that a combination of zosuquidar and polysorbate 20 may potentiate inhibition of P-gp-mediated efflux. P-gp inhibition by zosuquidar and polysorbate 20 in combination was assessed in a calcein-AM assay and in a transcellular etoposide permeability study in MDCKII-MDR1 and Caco-2 cells. Furthermore, solutions of etoposide, zosuquidar, and polysorbate 20 were orally administered to Sprague Dawley rats. Zosuquidar elicited a high level of nonspecific adsorption to various labware, which significantly affected the outcomes of the in vitro studies. Still, at certain zosuquidar and polysorbate 20 concentrations, additive P-gp inhibition was observed in vitro. In vivo, however, oral etoposide bioavailability decreased by coadministration of both zosuquidar and polysorbate 20 when compared to coadministration of etoposide with zosuquidar alone. For future formulation development, the present study provided important and novel knowledge about nonspecific zosuquidar adsorption, as well as insights into combinational P-gp inhibition by a third-generation P-gp inhibitor and a P-gp-inhibiting nonionic surfactant.
Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application
Authors: Prado Vinicius Costa , Moenke Kauani , Osmari Bárbara Felin , Pegoraro Natháli Schopf , Oliveira Sara Marchesan , Cruz Letícia
Published: January 2023

Irritant contact dermatitis is usually treated with corticosteroids, which cause expressive adverse effects. Sesamol is a phenolic compound with anti-inflammatory and antioxidant properties. This study was designed to evaluate a hydrogel containing sesamol-loaded ethylcellulose nanocapsules for the treatment of irritant contact dermatitis. The nanocapsules presented a size in the nanometric range, a negative zeta potential, a sesamol content close to the theoretical value (1 mg/mL), and a 65% encapsulation efficiency. Nanoencapsulation protected sesamol against UVC-induced degradation and increased the scavenging activity assessed by ABTS and DPPH radicals. The hydrogels were prepared by thickening the nanocapsule suspensions with guar gum (2.5%). The hydrogels maintained the nanometric size of the nanocapsules and a sesamol content of approximately 1 mg/g. The HET-CAM assay classified the hydrogels as nonirritating. The in vitro release of the hydrogel containing sesamol in the nanoencapsulated form demonstrated an initial burst effect followed by a prolonged sesamol release and a lower skin permeation in comparison with the hydrogel containing free sesamol. In addition, it exhibited the best anti-inflammatory effect in the irritant contact dermatitis model induced by croton oil, reducing ear edema and inflammatory cells infiltration, similar to dexamethasone (positive control). Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis.
The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation
Authors: Kasim Johanes K. , Hong Jiwon , Hickey Anthony J. R. , Phillips Anthony R. J. , Windsor John A. , Harris Paul W. R. , Brimble Margaret A. , Kavianinia Iman
Published: January 2023

Pancreatic ductal adenocarcinoma remains a highly debilitating condition with no effective disease-modifying interventions. In our search for natural products with promising anticancer activity, we identified the aminolipopeptide trichoderin A as a potential candidate. While it was initially isolated as an antitubercular peptide, we provide evidence that it is also selectively toxic against BxPC-3 and PANC-1 human pancreatic ductal adenocarcinoma cells cultured under glucose deprivation. This has critical implications for the pancreatic ductal adenocarcinoma, which is characterized by nutrient deprivation due to its hypovascularized network. We have also successfully simplified the trichoderin A peptide backbone, allowing greater accessibility to the peptide for further biological testing. In addition, we also conducted a preliminary investigation into the role of peptide lipidation at the N-terminus. This showed that analogues with longer fatty acyl chains exhibited superior cytotoxicity than those with shorter acyl chains. Further structural optimization of trichoderin A is anticipated to improve its biological activity, whilst ongoing mechanistic studies to elucidate its intracellular mechanism of action are conducted in parallel.
Grant Report on the Transcranial near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE) Study
Authors: Iosifescu Dan , Collins Katherine , Hurtado-Puerto Aura , Irvin Molly , Clancy Julie , Sparpana Allison , Sullivan Elizabeth , Parincu Zamfira , Ratai Eva-Maria , Funes Christopher , Weerasekera Akila , Dmochowski Jacek , Cassano Paolo
Published: January 2023

We report on the rationale and design of an ongoing National Institute of Mental Health (NIMH) sponsored R61-R33 project in major depressive disorder (MDD). Current treatments for MDD have significant limitations in efficacy and side effect burden. There is a critical need for device-based treatments in MDD that are efficacious, well-tolerated, and easy to use. This project focuses on the adjunctive use of the transcranial photobiomodulation (tPBM) with near-infrared (NIR) light for the treatment of MDD. tPBM with NIR light penetrates robustly into the cerebral cortex, stimulating the mitochondrial respiratory chain, and also significantly increases cerebral blood flow (CBF). In the R61 phase, we will conduct target engagement studies to demonstrate dose-dependent effects of tPBM on the prefrontal cortex (PFC) CBF, using the increase in fMRI blood-oxygenation-level-dependent (BOLD) signal levels as our Go/No-go target engagement biomarker. In the R33 phase, we will conduct a randomized clinical trial of tPBM vs. sham in MDD to establish the target engagement and evaluate the association between changes in the biomarker (BOLD signal) and changes in clinical symptoms, while also collecting important information on antidepressant effects, safety, and tolerability. The study will be done in parallel at New York University/the Nathan Kline Institute (NYU/NKI) and at Massachusetts General Hospital (MGH). The importance of this study is threefold: 1. it targets MDD, a leading cause of disability worldwide, which lacks adequate treatments; 2. it evaluates tPBM, which has a well-established safety profile and has the potential to be safe in at-home administration; and 3. it uses fMRI BOLD changes as a target engagement biomarker. If effects are confirmed, the present study will both support short-term clinical development of an easy to scale device for the treatment of MDD, while also validating a biomarker for the development of future, novel modulation strategies.
Extended Representation of Mueller Matrices
Authors: San José Ignacio , Gil José J.
Published: January 2023

The so-called arbitrary decomposition of a given Mueller matrix into a convex sum of nondepolarizing constituents provides a general framework for parallel decompositions of polarimetric interactions. Even though arbitrary decomposition can be performed through an infinite number of sets of components, the nature of such components is subject to certain restrictions which limit the interpretation of the Mueller matrix in terms of simple configurations. In this communication, a new approach based on the addition of some portion of a perfect depolarizer before the parallel decomposition is introduced, leading to a set of three components which depend, respectively, on the first column, the first row, and the remaining 3 × 3 submatrix of the original Mueller matrix, so that those components inherit, in a decoupled manner, the polarizance vector, the diattenuation vector, and the combined complementary polarimetric information on depolarization and retardance.
Compact and Low-Power-Consumption CO Sensor Using a QCL with Intermittent Scanning Technique
Authors: Zhang Qinduan , Hu Jie , Wei Yubin , Li Binkai , Liu Guancheng , Zhang Tingting , Wang Zhaowei , Gong Weihua , Liu Tongyu
Published: January 2023

A compact and low-power-consumption gas sensor using a quantum cascade laser (QCL) emitting at 4.6 μm for measurement of carbon monoxide (CO) was proposed and experimentally demonstrated. A compact sensor structure with a physical dimension of 14 × 10 × 6.5 cm3 was designed. A new intermittent scanning technique was used to drive the QCL to reduce the power consumption of the system. In this technique, the power consumption of the sensor is as low as 1.08 W, which is about 75% lower than the conventional direct absorption technology. The stability of the CO sensor was demonstrated by continuously monitoring CO concentration for more than 1 h. In the concentration range of 10 ppm to 500 ppm, the CO sensor exhibited a satisfactory linear response (R-square = 0.9998). With an integration time of 202 s, the minimum detection limit was increased to 4.85 ppb, based on an Allan deviation analysis.
Chemical Profile, Antioxidant and Anti-Inflammatory Potency of Extracts of Vitex madiensis Oliv. and Crossopteryx febrifuga (Afzel ex G. Don)
Authors: Boungou-Tsona Ghislaine , Gainche Maël , Decombat Caroline , Ripoche Isabelle , Bikindou Kevin , Delort Laetitia , Caldefie-Chézet Florence , Loumouamou Aubin , Chalard Pierre
Published: January 2023

Vitex madiensis Oliv. (Lamiaceae) and Crossopteryx febrifuga (Rubiaceae), two plants commonly used in traditional African medicines to treat malaria and pain, were studied either to determine their chemical profiles or to evaluate their antioxidant and anti-inflammatory activities. In this study, we investigated leaves, trunk bark, root bark and fruits methanolic extracts of both plants in order to find out which part of the plant is responsible for the activity. The analyses of the chemical profiles allowed us to confirm the presence of several ecdysteroids, especially 20-hydroxyecdysone in some parts of V. madiensis and to highlight the presence of organic acids and phenol derivatives in C. febrifuga. Among the four parts of the plants studied, only the fruits extract of C. febrifuga could present anti-inflammatory activity by decreasing ROS production. The leaves and trunk bark extracts of V. madiensis showed significant free radical scavenging activity compared to ascorbic acid, and the same extracts decrease ROS production significantly. The activity of these two extracts could be explained by the presence of ecdysteroids and flavonoids. The ROS production inhibition of V. madiensis is particularly interesting to investigate with further analyses.