bluuebunny/crossref_metadata_2025 huggingface dataset:
Overturning in the Subpolar North Atlantic Program: A New International Ocean Observing System
Authors: Susan Lozier M. , Bacon Sheldon , Bower Amy S. , Cunningham Stuart A. , Femke de Jong M. , de Steur Laura , deYoung Brad , Fischer Jürgen , Gary Stefan F. , Greenan Blair J. W. , Heimbach Patrick , Holliday Naomi P. , Houpert Loïc , Inall Mark E. , Johns William E. , Johnson Helen L. , Karstensen Johannes , Li Feili , Lin Xiaopei , Mackay Neill , Marshall David P. , Mercier Herlé , Myers Paul G. , Pickart Robert S. , Pillar Helen R. , Straneo Fiammetta , Thierry Virginie , Weller Robert A. , Williams Richard G. , Wilson Chris , Yang Jiayan , Zhao Jian , Zika Jan D.
Published: August 2016

For decades oceanographers have understood the Atlantic meridional overturning circulation (AMOC) to be primarily driven by changes in the production of deep-water formation in the subpolar and subarctic North Atlantic. Indeed, current Intergovernmental Panel on Climate Change (IPCC) projections of an AMOC slowdown in the twenty-first century based on climate models are attributed to the inhibition of deep convection in the North Atlantic. However, observational evidence for this linkage has been elusive: there has been no clear demonstration of AMOC variability in response to changes in deep-water formation. The motivation for understanding this linkage is compelling, since the overturning circulation has been shown to sequester heat and anthropogenic carbon in the deep ocean. Furthermore, AMOC variability is expected to impact this sequestration as well as have consequences for regional and global climates through its effect on the poleward transport of warm water. Motivated by the need for a mechanistic understanding of the AMOC, an international community has assembled an observing system, Overturning in the Subpolar North Atlantic Program (OSNAP), to provide a continuous record of the transbasin fluxes of heat, mass, and freshwater, and to link that record to convective activity and water mass transformation at high latitudes. OSNAP, in conjunction with the Rapid Climate Change–Meridional Overturning Circulation and Heatflux Array (RAPID–MOCHA) at 26°N and other observational elements, will provide a comprehensive measure of the three-dimensional AMOC and an understanding of what drives its variability. The OSNAP observing system was fully deployed in the summer of 2014, and the first OSNAP data products are expected in the fall of 2017.
Changes in Wind Speed under Heat Waves Enhance Urban Heat Islands in the Beijing Metropolitan Area
Authors: Li Dan , Sun Ting , Liu Maofeng , Wang Linlin , Gao Zhiqiu
Published: August 2016

The interaction between urban heat islands (UHIs) and heat waves (HWs) is studied using measurements collected at two towers in the Beijing, China, metropolitan area and an analytical model. Measurements show that 1) the positive interaction between UHIs and HWs not only exists at the surface but also persists to higher levels (up to ~70 m) and 2) the urban wind speed is enhanced by HWs during daytime but reduced during nighttime as compared with its rural counterpart. A steady-state advection–diffusion model coupled to the surface energy balance equation is then employed to understand the implication of changes in wind speed on UHIs, which reveals that the observed changes in wind speed positively contribute to the interaction between UHIs and HWs in both daytime and nighttime. The vertical structure of the positive interaction between UHIs and HWs is thus likely an outcome resulting from a combination of changes in the surface energy balance and wind profile.
Diurnal Variations of the Land–Sea Breeze and Its Related Precipitation over South China
Authors: Chen Xingchao , Zhang Fuqing , Zhao Kun
Published: August 2016

Convection-permitting numerical experiments using the Weather Research and Forecasting (WRF) Model are performed to examine the diurnal cycles of land and sea breeze and its related precipitation over the south China coastal region during the mei-yu season. The focus of the analyses is a 10-day simulation initialized with the average of the 0000 UTC gridded global analyses during the 2007–09 mei-yu seasons (11 May–24 June) with diurnally varying cyclic lateral boundary conditions. Despite differences in the rainfall intensity and locations, the simulation verified well against averages of 3-yr ground-based radar, surface, and CMORPH observations and successfully simulated the diurnal variation and propagation of rainfall associated with the land and sea breeze over the south China coastal region. The nocturnal offshore rainfall in this region is found to be induced by the convergence line between the prevailing low-level monsoonal wind and the land breeze. Inhomogeneity of rainfall intensity can be found along the coastline, with heavier rainfall occurring in the region with coastal orography. In the night, the mountain–plain solenoid produced by the coastal terrain can combine with the land breeze to enhance offshore convergence. In the daytime, rainfall propagates inland with the inland penetration of the sea breeze, which can be slowed by the coastal mountains. The cold pool dynamics also plays an essential role in the inland penetration of precipitation and the sea breeze. Dynamic lifting produced by the sea-breeze front is strong enough to produce precipitation, while the intensity of precipitation can be dramatically increased with the latent heating effect.
The Impact of the Extreme Winter 2015/16 Arctic Cyclone on the Barents–Kara Seas
Authors: Boisvert Linette N. , Petty Alek A. , Stroeve Julienne C.
Published: August 2016

Atmospheric data from the Atmospheric Infrared Sounder (AIRS) were used to study an extreme warm and humid air mass transported over the Barents–Kara Seas region by an Arctic cyclone at the end of December 2015. Temperature and humidity in the region was ~10°C (>3σ above the 2003–14 mean) warmer and ~1.4 g kg−1 (>4σ above the 2003–14 mean) wetter than normal during the peak of this event. This anomalous air mass resulted in a large and positive flux of energy into the surface via the residual of the surface energy balance (SEB), compared to the weakly negative SEB from the surface to the atmosphere expected for that time of year. The magnitude of the downwelling longwave radiation during the event was unprecedented compared to all other events detected by AIRS in December/January since 2003. An approximate budget scaling suggests that this anomalous SEB could have resulted in up to 10 cm of ice melt. Thinning of the ice pack in the region was supported by remotely sensed and modeled estimates of ice thickness change. Understanding the impact of this anomalous air mass on a thinner, weakened sea ice state is imperative for understanding future sea ice–atmosphere interactions in a warming Arctic.
The Consequences of School Dropout among Serious Adolescent Offenders
Authors: Na Chongmin
Published: August 2016

Objectives:

Drawing on labeling and routine activities perspectives, this study investigates whether within-individual change in the school dropout status is associated with the risk of subsequent offending and arrest among serious adolescent offenders.

Methods:

Longitudinal panel data and a modified version of conventional random-effects models are used as a potential outcome model of causality to directly compare the outcomes before and after the change in the school dropout status.

Results:

School dropout significantly increases the likelihood of rearrest, but there is no statistically discernable impact of dropping out of school on self-reported reoffending.

Conclusions:

The current study adds insights into the school dropout literature by exploring the role of school dropout as one of the contingencies of “differential social reaction” or “secondary sanctioning” processes in which arrest leads to a greater risk of subsequent arrest.
Characteristics of Pregnant Women With Hepatitis B Virus Infection in 5 US Public Health Jurisdictions, 2008-2012
Authors: Walker Tanja Y. , Smith Emily A. , Fenlon Nancy , Lazaroff Julie E. , Dusek Cristina , Fineis Patrick , Crowley Susan A. , Benson Ruthie , Veselsky Steven L. , Murphy Trudy V.
Published: August 2016

Objective:

We estimated the prevalence of hepatitis B surface antigen (HBsAg), a serologic marker of active hepatitis B virus (HBV) infection, among pregnant women, and estimated the proportion HBsAg-positive pregnant women who had received additional recommended testing.

Methods:

From 2008 through 2012, Perinatal Hepatitis B Prevention Programs (PHBPPs) in Florida, Michigan, Minnesota, New York City, and Texas prospectively collected data on demographic characteristics of HBsAg-positive pregnant women. We estimated the prevalence of HBsAg positivity among pregnant women by demographic characteristics using natality data. PHBPPs (excluding Texas) collected additional recommended testing (for hepatitis B e antigen [HBeAg] and/or HBV deoxyribonucleic acid [DNA]) among HBsAg-positive pregnant women to measure levels of viremia.

Results:

During the study period, 15,205 HBsAg-positive women were case-managed. The median age of HBsAg-positive women was 29 years; prenatal HBsAg screening was at a median of 27 weeks pre-delivery. Of 15,205 HBsAg-positive women, 11,293 (74.3%) were foreign-born. In four PHBPPs with 14,098 pregnancies among 12,214 HBsAg-positive women, HBeAg and/or HBV DNA testing was documented for 2,794 (19.8%) pregnancies. The estimated prevalence of HBsAg positivity among pregnant women was 0.38% (17,023 of 4,468,773). HBsAg prevalence was highest among foreign-born women from most regions in Asia (2.0% to 8.7%; with the exception of South Asia, 0.4%) and Africa (3.4%).

Conclusion:

One-fifth of HBsAg-positive pregnant women had documentation for HBeAg and/or HBV DNA, and about one-third reported receiving care for HBV infection during a case-managed pregnancy. Greater emphasis is needed on prenatal evaluation for HBV liver disease care and treatment among pregnant women with HBV infection.
Distribution dynamics of property crime rates in the United States
Authors: Moro Alessandro
Published: August 2016

Using crime data for the 48 continental and conterminous US states and the distribution dynamics approach, this paper detects two distinct phases in the evolution of the property crime distribution: a period of strong convergence (1971–1980) is followed by a tendency towards divergence and bimodality (1981–2010). Moreover, the analysis reveals that differences in income per capita and police can explain the emergence of a bimodal shape in the distribution of property crime: in fact, after conditioning on these variables, the bimodality completely disappears. This empirical evidence is consistent with the predictions of a two-region model, that stresses the importance of income inequality in determining the dynamics of the property crime distribution.
Urban development and visual culture: Commodifying the gaze in the regeneration of Tigné Point, Malta
Authors: Speake Janet
Published: August 2016

This paper explores some of the hitherto under-researched intersections between urban (re)development, urban planning and visual culture. What emerges is an academic context that, to date, has largely compartmentalised discrete literatures on ‘view’, ‘value of the view’ and cityscape change, (re)imagineering and (re)scripting). It shows how materialising processes associated with the commodification of a panoramic view in politico-economic and cultural terms can be used to transform and regenerate along neoliberal lines. It demonstrates how panoramas, when treated as a commodity within the context of neoliberal capitalism, are appropriated, (re)imagined and (re)scripted by architects and property developers to create high status, residential and commercial space for an affluent élite. As such, panoramas are a mechanism for the acceleration of capital accumulation that inherently create new and reinforce existing spatial inequalities. This study draws on research into the commodification of the view of the historic city of Valletta in the redevelopment of Tigné Point, the largest, most comprehensive regeneration scheme in Malta in recent years.
Positive Illusions in the Academic Context
Authors: Chung Joanne , Schriber Roberta A. , Robins Richard W.
Published: August 2016

In the present research, we examined academic self-enhancement in students ( N = 264) followed longitudinally through 4 years of college. We used social comparison (i.e., better-than-average ratings) and self-insight (i.e., criterion-based) approaches to assess the degree to which students self-enhanced in their self-perceptions of academic ability, with SAT scores, high school grade point average (GPA), and college GPA used as criterion measures. We also examined ethnic variability in academic self-enhancement. We found that academic self-enhancement (a) increased or decreased over the 4 years of college, depending on its operationalization, (b) tended to be adaptive according to social comparison indices, and (c) demonstrated a trajectory that differed by ethnicity, but ethnicity did not moderate the effect of academic self-enhancement on outcomes. We discuss the implications of the findings for debates about the adaptive value of self-enhancement, the magnitude of cultural differences, and how best to conceptualize and operationalize the construct.
Negotiating the Diagnostic Uncertainty of Genomic Test Results
Authors: Stivers Tanya , Timmermans Stefan
Published: August 2016

Clinicians order next-generation genomic testing to address diagnostic uncertainty about the cause of a patient’s symptoms. Based on video-recorded observations, we examine geneticists as they return exome sequencing results to families. We find that in consultations, clinical geneticists’ interpretations of genomic findings frequently go beyond the laboratory report. The news delivery offers parents insight into the basis of clinicians’ judgment but also invites parents’ involvement in the determination of genetic causality. Through this process, clinicians and parents collaborate to define the boundaries of uncertainty. We show that through collectively managing the causal ambiguities of genomic findings, clinicians and parents enact a care relationship that works to assuage underlying feelings of diagnostic uncertainty.
Cardiorespiratory Fitness, Adiposity, and Cardiometabolic Risk Factors in Schoolchildren: The FUPRECOL Study
Authors: Ramírez-Vélez Robinson , Daza Fernando , González-Jiménez Emilio , Schmidt-RioValle Jacqueline , González-Ruíz Katherine , Correa-Bautista Jorge E.
Published: August 2016

The aim of this study was to investigate the association between cardiorespiratory fitness (CRF) and cardiovascular risk factors (CVRF) in schoolchildren. A secondary aim was to evaluate the degree of association between overall and abdominal adiposity and CRF in a total of 1,875 children and adolescents attending public schools. We expressed CRF performance as the nearest stage (minute) completed and the estimated peak oxygen consumption. A CVRF ( Z score) was calculated and participants were divided into tertiles according to low and high levels of overall (sum of the skinfold thicknesses) and abdominal adiposity. Schoolchildren with a high-level of overall adiposity demonstrated significant differences in seven of the 10 variables analyzed (i.e., systolic and diastolic blood pressure, triglycerides, triglycerides/high density lipoproteins [HDL-c] ratio, total cholesterol, glucose, C-reactive protein [usCRP], HDL-c, low density lipoproteins [LDL-c], and cardiovascular risk score). Schoolchildren with high levels of both overall and abdominal adiposity and low CRF had the least favorable CVRF score.
News orgs post more often on Twitter than on Facebook
Authors: Cox Jennifer Brannock
Published: August 2016

This study uses a content analysis to examine Twitter and Facebook postings from six news organizations. A sample of 1,232 items was coded for author type, news topic, timeliness, and story type. Overall, 82 percent of news organizations’ social media postings were on Twitter compared with 18 percent on Facebook.
Newspapers use unnamed sources less often in high-stakes coverage
Authors: Sobel Meghan R. , Riffe Daniel
Published: August 2016

This analysis of unnamed sources in newspaper coverage of the attack on the U.S. Consulate in Benghazi, Libya, finds unnamed sources to be most common just after the attack and in its immediate aftermath. While unnamed sources were prevalent, they were less common than in studies of routine news coverage, suggesting journalists seeking transparency in reporting are less willing to grant source anonymity with high-stakes stories.
Mothering, Guiding, and Responding to Children: A Comparison of Women Abused and Not Abused by Intimate Partners
Authors: Ateah Christine A. , Radtke H. Lorraine , Tutty Leslie M. , Nixon Kendra , Ursel E. Jane
Published: August 2016

Intimate partner violence (IPV) has many negative outcomes for women, children, and families. However, researchers have opposing perspectives and findings with respect to the effects on mothering for abused women. The assumption by some service providers that abused mothers are compromised in their parenting generally ignores the larger issue of male violence and women’s and children’s safety. The question examined in this study was whether there were differences in reported positive parenting responses with children between women who have experienced IPV and those who have not experienced IPV. The sample consisted of 1,211 mothers and came from two studies: The National Longitudinal Survey of Children and Youth, and The Healing Journey: A Longitudinal Study of Mothers Affected by Intimate Partner Violence. The Positive Interaction and Rational Parenting scales, adapted from Strayhorn and Weidman’s Parenting Practices Scale, were used to measure parenting interactions. Bivariate correlations between the outcome variables and maternal age, maternal education, child age, and child sex were calculated to determine whether any of these variables were significantly related to the Positive Interaction Scale or Rational Parenting Scale. This was followed by ANCOVA to determine whether mothers who had experienced IPV differed in their scores on the two parenting scales from mothers who had not experienced IPV. Findings did not support the notion that abused women are compromised in their parenting responses with their children in regard to positive interactions and behavior management. Recommendations include a greater focus on the prevention of IPV, addressing the source of violence and providing appropriate support for mothers who experience IPV.
Gender Differences in the Relationship Between Changes in ADHD Symptoms, Executive Functions, and Self- and Parent-Report Depression Symptoms in Boys and Girls With ADHD: A 2-Year Follow-Up Study
Authors: Øie Merete , Hovik Kjell Tore , Andersen Per Normann , Czajkowski Nikolai Olavi , Skogli Erik Winther
Published: August 2016

Objective: This study was conducted to investigate the association between changes in ADHD symptoms, executive functions (EFs), and depression symptoms in girls and boys with ADHD over a 2-year period. Method: Thirty-six girls and 39 boys with ADHD, 18 typically developing (TD) girls and 29 TD boys (ages 9-16) were included. Assessments of EFs, ADHD symptoms, and self- and parent-report of depression symptoms were carried out. Results: For girls, a reduction of inattention symptoms was associated with a decline in parent-rated depression symptoms. A reduction in hyperactivity/impulsivity was associated with a reduction in self-rated depression symptoms in boys, and an increase in girls. A reduction in inattention symptoms was associated with a modest increase in self-rated depression symptoms in both boys and girls. Conclusion: Gathering information from both the parents and the child with ADHD is important in determining how gender may be influencing symptom profiles.
A lifestyle intervention in primary care prevents deterioration of insulin resistance in patients with impaired glucose tolerance: A randomised controlled trial
Authors: Hellgren Margareta I. , Jansson Per-Anders , Wedel Hans , Lindblad Ulf
Published: August 2016

Aims: We hypothesised that the expected increase in insulin resistance over three years’ time in individuals with impaired glucose tolerance (IGT) and/or impaired fasting glucose could be attenuated by an intervention with focus on physical activity in ordinary primary care. Methods: We conducted a randomised controlled trial with 96 participants over three years. Examination of the participants included anthropometric measures, blood pressure, body weight and height, blood samples, an oral glucose tolerance test, and questionnaires about diet and lifestyle. The study subjects were randomised to either an intense intervention with information, group sessions, referral to physical activity and a step-counter ( n = 31), a less intense intervention without the group sessions ( n = 35), or care as usual group (CAUG) ( n = 30). Differences between the groups were analysed with general linear models adjusted for age, gender, baseline values and time in the intervention. Results: Individual insulin resistance increased in the CAUG. Due to having a similar effect, we combined the two intervention groups into a combined intervention group (CIG; n = 66) in the analyses. In individuals with IGT, the increase in the homeostatic model assessment-insulin resistance differed significantly between those in the CAUG and the CIG (Δ = 0.8; CI: 0.1–1.6; p = 0.034). Likewise, diastolic blood pressure decreased more in the CIG than in the CAUG (Δ = 5.1; CI: 0.1–10.0; p = 0.047). A total of 17 individuals developed Type 2 diabetes, 23% were in the CIG and 33% in the CAUG; so there was a 32% reduced risk in the intervention group. Conclusions: A lifestyle intervention focused on physical activity is feasible in ordinary primary care and prevents deterioration in insulin sensitivity in individuals with IGT over a three-year period.
Surgical Management of Fistula-in-ano Among Patients With Crohn’s Disease: Analysis of Outcomes After Fistulotomy or Seton Placement—Single-Center Experience
Authors: Papaconstantinou I. , Kontis E. , Koutoulidis V. , Mantzaris G. , Vassiliou I.
Published: August 2016

Background and Aim:

Fistula-in-ano is a common problem among patients with Crohn’s disease and carries significant morbidity. We aimed to study the outcomes of surgical treatment of fistula-in-ano after fistulotomy or seton placement in patients with perianal fistulizing Crohn’s disease.

Material and Methods:

A retrospective observational study of 59 patients diagnosed with Crohn’s disease, who were treated surgically for fistula-in-ano between 2010 and 2014 in our department. The assessment of disease complexity included a detailed physical examination, magnetic resonance imaging of the rectum, and examination under anesthesia. Outcomes for analysis included wound healing rate and postoperative incontinence.

Results:

High transsphincteric fistula was found in 44% of the patients, while mid or low transsphincteric fistulas were found in 51%. Three women (5%) had a rectovaginal fistula. All patients with high transsphincteric fistulas were treated with loose seton placement. Patients with mid- or low-level transsphincteric fistula were offered either fistulotomy or seton placement based on the clinical evaluation. The mean follow-up duration was 1.6 ± 1.1 years. In terms of recurrence, one patient treated with seton placement presented with recurrence 6 months after seton removal and one patient with fistulotomy failed to achieve wound healing. Minor incontinence was found in six patients treated with fistulotomy and in three patients treated with seton placement; however, this difference was not significant (chi-square = 1.723, df = 1, Monte–Carlo: p = 0.273).

Conclusion:

Fistulotomy could achieve good results in terms of wound healing and incontinence in strictly selected patients with Crohn’s disease suffering from low-lying transsphincteric fistulae. For more high-lying or complicated fistulae, seton placement is more appropriate. For high transsphincteric fistulae, the only option is placement of loose seton.
Original Research: Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development
Authors: Callahan Robert , Chestnut Barry A , Raafat Ahmed
Published: August 2016

Wap-Int3 transgenic females expressing the Notch4 intracellular domain (designated Int3) from the whey acidic protein promoter exhibit two phenotypes in the mammary gland: blockage of lobuloalveolar development and lactation, and tumor development with 100% penetrance. Previously, we have shown that treatment of Wap-Int3 tumor bearing mice with Imatinib mesylate (Gleevec) is associated with complete regression of the tumor. In the present study, we show that treatment of Wap-Int3 mice during day 1 through day 6 of pregnancy with Gleevec leads to the restoration of their lobuloalveolar development and ability to lactate in subsequent pregnancies in absence of Gleevec treatment. In addition, these mice do not develop mammary tumors. We investigated the mechanism for Gleevec regulation of Notch signaling and found that Gleevec treatment results in a loss of Int3 protein but not of Int3 mRNA in HC11 mouse mammary epithelial cells expressing Int3. The addition of MG-132, a proteasome inhibitor, shows increased ubiquitination of Int3 in the presence of Gleevec. Thus, Gleevec affects the stability of Int3 by promoting the degradation of Int3 via E3 ubiquitin ligases targeting it for the proteasome degradation. Gleevec is a tyrosine kinase inhibitor that acts on c-Kit and PDGFR. Therefore, we investigated the downstream substrate kinase GSK3β to ascertain the possible role that this kinase might play in the stability of Int3. Data show that Gleevec degradation of Int3 is GSK3β dependent. We have expanded our study of the effects Gleevec has on tumorigenesis of other oncogenes. We have found that anchorage-independent growth of HC11-c-Myc cells as well as tumor growth in nude mice is inhibited by Gleevec treatment. As with Int3, Gleevec treatment appears to destabilize the c-Myc protein but not mRNA. These results indicate that Gleevec could be a potential therapeutic drug for patients bearing Notch4 and/or c-Myc positive breast carcinomas.
Autonomous drone for delay-tolerant networks in indoor applications
Authors: Schoeneich Radosław O , Golański Marcin , Krok Bartosz , Czermiński Paweł
Published: August 2016

This article presents the idea and application of autonomous drones as mobile message ferries in delay-tolerant networks. The delay-tolerant network communication bases on messages ferrying called store-carry-forward paradigm. The messages ferrying can be realized by drones—an autonomous flying robots. For indoor application, drones are equipped with the sensors for distance and obstacle detection. The use of drones can be particularly effective in emergency scenarios where the human-rescuers’ activity is impossible due to hard unhealthy conditions. Our solution was tested in indoor scenario. The test results demonstrate good performance of our solution.
Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects
Authors: Yosaee Somaye , Khodadost Mahmoud , Esteghamati Alireza , Speakman John R. , Shidfar Farzad , Nazari Mahdiyeh Nasab , Bitarafan Vida , Djafarian Kurosh
Published: August 2016

Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, is a challenging public health issue. The aim of current study was to test the hypothesis that concentrations of plasma adropin and leptin differ between patients with MetS and comparable age- and sex-matched control groups. This case-control study involved 153 subjects (51 per group). The study group included obese subjects with MetS and the two control groups included weight-matched subjects without MetS (“healthy”: obese) and normal weight subjects without MetS. Body composition parameters were measured using bioelectrical impedance analysis. Plasma levels of adropin, leptin, and their ratio were measured. Leptin was significantly different between obese patients with/without MetS groups and normal weight subjects. Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p = .002). Compared with healthy obese and normal weight subjects, MetS subjects had lower levels of plasma adropin ( p < .001) and a lower plasma adropin to leptin ratio ( p < .001), which remained significant when adjusted for body fat mass by analysis of covariance ( p < .001). This study demonstrates low levels of adropin are correlated with MetS and hence identify it as a potentially protective agent against MetS development. Variation in adropin levels may partly explain the “healthy obese” phenomenon.
Post-ischaemic hyperperfusion in traumatic middle cerebral artery dissection detected by arterial spin labelling of magnetic resonance imaging
Authors: Nomura Motohiro , Tamase Akira , Kamide Tomoya , Mori Kentaro , Seki Syunsuke , Iida Yu , Suzuki Kei-ichiro , Aoki Takae , Hirano Ken-ichi , Takahashi Mitsuyuki , Kawabata Yuichi , Nakano Tatsu , Taguchi Hiroki
Published: August 2016

We report a patient with a traumatic middle cerebral artery dissection, which showed hyperperfusion in the territory supplied by the left middle cerebral artery. A 45-year-old man experienced speech disturbance and motor weakness in his right hemibody on the day following mild head trauma. His symptoms worsened on the fourth day. Magnetic resonance imaging showed narrowing in the left M1 portion of the middle cerebral artery. Angiography showed narrowing and dilatation in the left middle cerebral artery trunk. The lesion was diagnosed as a dissection of the middle cerebral artery. Arterial spin labelling of magnetic resonance imaging and single photon emission computed tomography showed increased cerebral blood flow in the left temporal region compared with the right. The patient was treated conservatively and the symptoms gradually improved. The hyperperfusion observed on arterial spin labelling and single photon emission computed tomography gradually improved and disappeared on the 25th day. This is the first reported case of traumatic middle cerebral artery dissection, which showed post-ischaemic hyperperfusion in the territory of the affected artery. To detect hyperperfusion in the brain, arterial spin labelling is a useful technique.
It is not pneumothorax: Multicystic lung lesion in a six-year-old child
Authors: Sobh Eman , Bahour Amira , Anis Shady Elia
Published: August 2016

Congenital cystic adenomatoid malformation (CCAM) – recently reported as congenital pulmonary airway malformation – is a rare abnormality of lung development. We present a case of a six-year-old child having a cystic lung lesion that proved to be CCAM after surgical resection. The child is performing well on follow-up.
Opioid-induced myoclonus and hyperalgesia following a short course of low-dose oral morphine
Authors: Woodward Owen Bleddyn , Naraen Sangeeta , Naraen Akriti
Published: August 2016

A 76-year-old man was admitted to hospital with a right-sided fractured neck of femur requiring repair via a cemented hemiarthroplasty. Intraoperatively he received 10 mg of intravenous morphine. Post-operatively he received a short course of low-dose oral opioids and subsequently developed myoclonic jerks and hyperalgesia. The opioids were discontinued and both adverse effects resolved. This case report discusses the concurrent development of myoclonus and hyperalgesia following a low dose of opioids and explores possible management options.
Humans of New York and ethical reflections in the digital age
Authors: Erdener Jasmine
Published: August 2016

The massive global success of the Humans of New York blog presents a view of the world which transcends our individual differences and allows a feeling of universal human connection. Yet, this feeling of universality often simplifies other forces at work, particularly masking structural patterns of exploitation or oppression. This article examines the ethical dimensions of the blog, specifically focusing on photos of Syrian refugees as presented to a Western audience.
Extracorporeal Life Support in Multisystem Smooth Muscle Dysfunction Syndrome
Authors: Prabhu Sudesh , Fox Scott , Mattke Adrian , Armes Jane E. , Alphonso Nelson
Published: August 2016

We describe an infant with congenital mydriasis, patent ductus arteriosus (PDA), pulmonary hypertension, and cystic lung disease. She had all the major components of multisystemic smooth muscle dysfunction syndrome. Due to progressive respiratory deterioration, she required surgical PDA interruption, extracorporeal life support, and subsequent prolonged respiratory support. Genetic testing revealed ACTA2 R179H mutation and cystic lung disease on biopsy.
Culturally Competent Informed-Consent Process to Evaluate a Social Policy for Older Persons With Low Literacy
Authors: Aguila Emma , Weidmer Beverly A. , Rivera Illingworth Alfonso , Martinez Homero
Published: August 2016

The informed-consent process seeks to provide complete information to participants about a research project and to protect personal information they may disclose. In this article, we present an informed-consent process that we piloted and improved to obtain consent from older adults in Yucatan, Mexico. Respondents had limited fluency in Spanish, spoke the local Mayan language, and had some physical limitations due to their age. We describe how we adapted the informed-consent process to comply with U.S. and Mexican regulations, while simplifying the forms and providing them in Spanish and Mayan. We present the challenges and lessons learned when dealing with low-literacy older populations, some with diminished autonomy, in a bilingual context and a binational approach to the legal framework.
Complex Feeding Decisions
Authors: Miles Anna , Watt Tanya , Wong Wei-Yuen , McHutchison Louise , Friary Philippa
Published: August 2016

Objective: Where swallowing difficulties are chronic or progressive, or a patient is palliative, tube feeding is often not deemed appropriate. Instead, patients continue to eat and drink despite the risks of pneumonia and death. There is currently little evidence to guide clinical practice in this field often termed “risk feeding.” This qualitative study investigated staff, patient, and family member perceptions of risk feeding practices in one New Zealand hospital. Method: Twenty-nine staff members and six patients and/or their family were interviewed. Results: Thematic analysis revealed four global themes: supporting practice, communication, complexity of feeding decisions, and patient and family-centered care. Staff described limited education and organizational policy around risk feeding decisions. Communication was considered a major factor in the success. Conclusion: Feeding decisions are complex in the hospital environment. The themes identified in this study provide a foundation for hospital guideline development and implementation.
SGA Children in Pediatric Primary Care
Authors: Gallo Patrizia , Cioffi Luigi , Limauro Raffaele , Farris Evelina , Bianco Vincenzo , Sassi Roberto , De Giovanni Maria , Gallo Valeria , D’Onofrio Antonietta , Di Maio Salvatore
Published: August 2016

Background: Epidemiologic evidences suggest a strong association between low birth weight and some diseases in adult life ( hypertension, diabetes, cardiovascular diseases).Aim of this study was to evaluate the obesity/overweight prevalence in a population of children born small for gestation age, SGA children 400, 208 males and 192 females compared to a population of children born appropriate for gestational age 6818 AGA children, 3502 males and 3316 females, during childhood. Our intention was also to build the natural history of weight gain during prepubertal age in children born SGA and AGA. Design and Methods: Observational prospective longitudinal study. We followed our patients from January2001 up to December 2010; weight, height and body mass index (BMI) were evaluated in all the SGA and AGA children. BMI z-score range for defining overweight and obesity was, respectively, 1.13 to 1.7 and >1.7 according to CDC growth charts. Results: In transversal evaluation, we prove that 10-year-old SGA females are twice obese and more overweight compared to equal age AGA females. In longitudinal evaluation, we highlight different observations: SGA children obese at 2 years are still obese at 10 years; the number of obese SGA children increases gradually until the age of 10; AGA children, appear to be less obese than SGA children at 10 years. Conclusion: SGA males and females are more obese at 5 and 10 years compared to the AGA population. Primary care pediatricians, through early detection of the children at risk, can carry out an effective obesity prevention project in SGA children.
Role of Participation of Pediatricians in the “Activated Autism Practice” Program in Practicing Children With Autism Spectrum Disorders at the Primary Care Setting
Authors: Kairys Steven W. , Petrova Anna
Published: August 2016

Primary care of children with autism spectrum disorders (ASD) is an important public health concerns. In this survey study of 73 pediatricians, we determined whether pediatricians’ practice of autism screening and perception of management of ASD is associated with participation in a learning collaborative, “Activated Autism Practice”. Overall, the majority recognized the lack of care coordination, inadequate time, poor reimbursement, and language difference as barriers to the delivery of medical care to children with ASD. Pediatricians with prior training were more likely to report use of autism-specific screening and understanding the different aspects of ASD management including the need to coordinate special services and long-term surveillance at pediatric sites. Therefore, participation in “Activated Autism Practice” may facilitate use of ASD-specific screening and manage ASD cases as a complex of neurodevelopmental/underlying problems with the need for enhancement of clinical attention and coordination of medical care at the pediatric primary care level.
Charting a Course for Implementation Research in Oral Health
Authors: Clark D.B. , Ducharme L.
Published: August 2016

Knowledge Transfer Statement: This article provides an overview of implementation science and outlines NIDCR’s interest and commitment to research that decreases time from development through implementation of evidence-based oral health interventions.
Cilia are required for asymmetric nodal induction in the sea urchin embryo
Authors: Tisler Matthias , Wetzel Franziska , Mantino Sabrina , Kremnyov Stanislav , Thumberger Thomas , Schweickert Axel , Blum Martin , Vick Philipp
Published: August 2016

Background

Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates, asymmetric nodal induction results from a cilia-driven leftward fluid flow at the left-right organizer (LRO), a ciliated epithelium present during gastrula/neurula stages. Conservation of LRO and flow beyond the vertebrates has not been reported yet.

Results

Here we study sea urchin embryos, which use nodal to establish larval LR asymmetry as well. Cilia were found in the archenteron of embryos undergoing gastrulation. Expression of foxj1 and dnah9 suggested that archenteron cilia were motile. Cilia were polarized to the posterior pole of cells, a prerequisite of directed flow. High-speed videography revealed rotating cilia in the archenteron slightly before asymmetric nodal induction. Removal of cilia through brief high salt treatments resulted in aberrant patterns of nodal expression. Our data demonstrate that cilia - like in vertebrates - are required for asymmetric nodal induction in sea urchin embryos.

Conclusions

Based on these results we argue that the anterior archenteron represents a bona fide LRO and propose that cilia-based symmetry breakage is a synapomorphy of the deuterostomes.
Psychosocial Adjustment and Perceived Risk Among Adolescent Girls From Families With BRCA1/2 or Breast Cancer History
Authors: Bradbury Angela R. , Patrick-Miller Linda , Schwartz Lisa A. , Egleston Brian L. , Henry-Moss Dare , Domchek Susan M. , Daly Mary B. , Tuchman Lisa , Moore Cynthia , Rauch Paula K. , Shorter Rebecca , Karpink Kelsey , Sands Colleen Burke
Published: August 2016

Purpose

To evaluate the impact of breast cancer family history and maternal BRCA1/2 mutation on the psychosocial adjustment and perceived risk in girls age 11 to 19 years old.

Materials and Methods

Girls age 11 to 19 years old with one or more relatives with breast cancer or a familial BRCA1/2 mutation (breast cancer family history [BCFH] positive, n = 208; n = 69 with BRCA1/2-positive mother), peers (BCFH negative, n = 112), and their mothers completed assessments of psychosocial adjustment, breast cancer–specific distress, and perceived risk of breast cancer.

Results

General psychosocial adjustment did not differ significantly between BCFH-positive and BCFH-negative girls, either by self-report or mother report, except for higher self-esteem among BCFH-positive girls (P = .01). BCFH-positive girls had higher breast cancer–specific distress than BCFH-negative girls (P < .001), but girls from BRCA1/2-positive families did not differ from other BCFH-positive peers. BCFH-positive girls were more likely to report themselves at increased self-risk for breast cancer in adulthood than BCFH-negative peers (74% v 33%, respectively; P ≤ .001). Girls from BRCA1/2-positive families were more likely than other BCFH-positive and BCFH-negative peers to report themselves at increased risk (P < .001). In all groups, perceived risk of breast cancer was associated with older age. Higher breast cancer–specific distress among adolescent girls was associated with higher self-perceived risk of breast cancer and higher maternal breast cancer–specific distress.

Conclusion

Adolescent girls from BRCA1/2-positive and breast cancer families have higher self-esteem and do not have poorer psychosocial adjustment than peers. However, they do experience greater breast cancer–specific distress and perceived risk of breast cancer, particularly among older girls. Understanding the impact is important to optimize responses to growing up in families at familial and genetic risk for breast cancer, particularly given the debate over the genetic testing of children for cancer susceptibility in adulthood.
Baseline Metabolic Tumor Volume Predicts Outcome in High–Tumor-Burden Follicular Lymphoma: A Pooled Analysis of Three Multicenter Studies
Authors: Meignan Michel , Cottereau Anne Ségolène , Versari Annibale , Chartier Loïc , Dupuis Jehan , Boussetta Sami , Grassi Ilaria , Casasnovas René-Olivier , Haioun Corinne , Tilly Hervé , Tarantino Vittoria , Dubreuil Julien , Federico Massimo , Salles Gilles , Luminari Stefano , Trotman Judith
Published: August 2016

Purpose

Identifying patients at high risk of progression and early death among those with high-tumor-burden follicular lymphoma (FL) is unsatisfactory with current prognostic models. This study aimed to determine the prognostic impact of the total metabolic tumor volume (TMTV) measured at baseline with [18F]fluorodeoxyglucose/positron emission tomography-computed tomography ([18F]FDG/PET-CT) scans and its added value to these models.

Patients and Methods

A pooled analysis was performed by using patient data and centrally reviewed baseline PET-CT scans for 185 patients with FL who were receiving immunochemotherapy within three prospective trials. TMTV was computed by using the 41% maximum standardized uptake value thresholding method, and the optimal cutoff for survival prediction was determined.

Results

Median age was 55 years, 92% of patients had stage III to IV disease, 37% had a Follicular Lymphoma International Prognostic Index (FLIPI) score of 3 to 5, and 31% had a FLIPI2 score of 3 to 5. With a median follow-up of 64 months, overall 5-year progression-free survival (PFS) was 55% and overall survival (OS) was 92%. Median TMTV was 297 cm3 (quartile 1 through quartile 3, 135 to 567 cm3). The optimal cutoff identified was 510 cm3, with a markedly inferior survival in the 29% of patients with TMTV > 510 cm3. Five-year PFS was 33% versus 65% (hazard ratio [HR], 2.90; P < .001), and 5-year OS was 85% versus 95% (HR, 3.45; P = .010). On multivariable analysis, TMTV (HR, 2.3; P = .002) and FLIPI2 score (HR, 2.2; P = .002) were independent predictors of PFS. In combination, they identify three risk groups: high TMTV and intermediate-to-high FLIPI2 score with 5-year PFS of 20% (HR, 5.0; P < .001), high TMTV or intermediate-to-high FLIPI2 score with 5-year PFS of 46% (HR, 2.1; P = .007), and low TMTV and low FLIP2 with 5-year PFS of 69%.

Conclusion

Baseline TMTV is a strong independent predictor of outcome in FL. In combination with FLIPI2 score, it identifies patients at high risk of early progression. It warrants further validation as a biomarker for development of first-line PET-adapted approaches in FL.
Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures
Authors: Kocijan Roland , Muschitz Christian , Geiger Elisabeth , Skalicky Susanna , Baierl Andreas , Dormann Rainer , Plachel Fabian , Feichtinger Xaver , Heimel Patrick , Fahrleitner-Pammer Astrid , Grillari Johannes , Redl Heinz , Resch Heinrich , Hackl Matthias
Published: August 2016

Context:

Established bone turnover markers do not reflect fracture risk in idiopathic male and premenopausal osteoporosis and the role of microRNAs (miRNAs) in these patients is currently unclear. miRNAs are a class of small non-coding RNAs that regulate gene expression and bone tissue homeostasis. They are considered a new class of endocrine regulators with promising potential as biomarkers.

Objective:

Evaluation of circulating miRNA signatures in male and female subjects with idiopathic and postmenopausal osteoporotic low-traumatic fractures.

Design, Setting, and Patients:

This was a case-control study of cross-sectional design of 36 patients with prevalent low-traumatic fractures and 39 control subjects

Main Outcome Measures:

One hundred eighty-seven miRNAs were quantified in serum by qPCR, compared between groups and correlated with established bone turnover markers.

Results:

Significant differences in serum levels of circulating miRNAs were identified in all three subgroups (46 in premenopausal, 52 in postmenopausal, 55 in male). A set of 19 miRNAs was consistently regulated in all three subgroups. Eight miRNAs [miR-152-3p, miR-30e-5p, miR-140-5p, miR-324-3p, miR-19b-3p, miR-335-5p, miR-19a-3p, miR-550a-3p] were excellent discriminators of patients with low-traumatic fractures, regardless of age and sex, with area under the curve values > 0.9. The 11 remaining miRNAs showed area under the curve values between 0.81 and 0.89. Correlation analysis identified significant correlations between miR-29b-3p and P1NP, and miR-365-5p and iPTH, TRAP5b, P1NP and Osteocalcin, as well as BMDL1–L4 and miR-19b-3p, miR-324-3p, miR-532-5p, and miR-93-5p.

Conclusions:

Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature.