bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a new recurrence-free survival prediction nomogram for patients with primary non-muscle-invasive bladder cancer based on preoperative controlling nutritional status score
Authors: Zhao Liwei , Huang Jiaguo , Sun Ji , Wang Kai , Tai Shengcheng , Hua Runmiao , Yu Yufu , Fan Yi
Published: June 2021

Bladder cancer is the second most common neoplasm in the urogenital system in terms of morbidity and mortality, and there is an urgent need for a more accurate assessment of the individual prognosis in patients with primary non-muscle-invasive bladder cancer (NMIBC). The Controlling Nutritional Status (CONUT) score is an emerging biomarker score, which has been confirmed to have prognostic value in various malignant tumors. A total of 94 patients with NMIBC were analyzed retrospectively between January 2011 and December 2015.The Kaplan-Meier method was used to assess recurrence-free survival (RFS), and log-rank tests was used to test the equivalences of survival curves. We used univariate and multivariate Cox proportional hazards regression model to identify important predictors of RFS. In univariate analysis, age, history of smoking, pathological T stage, tumor grade, tumor size, and CONUT score were significantly correlated with RFS. Multivariate analysis indicated that CONUT score(HR = 3.855, 95% CI 1.242–11.970, p = 0.020) was an independent predictor of RFS in patients with NMIBC. Based on significant parameters in multivariate analysis and reliable recurrence predictors determined in predictive models and relevant guidelines, a new age-, history of smoking-, pathologic factors- and the CONUT score-based scoring model was developed to predict recurrence of NMBIC. In addition, we internally validated the nomogram using the consistency index and calibration plots, which showed the model has high prediction accuracy(c-index = 0.851). The development of a new nomogram based on CONUT score could increase the accuracy of recurrence prediction and improve individualized treatment plan for patients with NMIBC.
Mechanisms Involved in the Anti-Tumor Effects of Toosendanin in Glioma Cells
Authors: huang haiyan , Zhang Chaochao , Gao Haijun , Liu Ziqiang , Lai Jiacheng , Zhan Zhixin , Chen Yong
Published: June 2021

Background: Toosendanin (TSN) is a triterpenoid compound mainly used as an ascaris repellant. Recent studies have shown that it possesses antitumor effects in many types of tumor cells. However, the effects of TSN on glioma cells have rarely been reported. Methods: Different assays were performed to investigate the effects of TSN on the different glioma cell lines including U87MG and LN18. The assays included colony formation, wound healing, and transwell assays. Furthermore, Hoechst 3342 staining, flow cytometry, and western blotting analysis were performed to investigate the apoptotic activities of TSN. Finally, the results were confirmed using a xenograft tumor model that comprised of nude mice. Results: In vitro, the CCK-8 and colony formation assays showed that TSN effectively inhibited glioma cell proliferation. Moreover, the inhibitory effects on glioma cell migration and invasion were demonstrated through the wound healing and transwell assays, respectively. Hoechst 33342 staining, flow cytometry, and western blotting assays demonstrated the significant effect of TSN in the apoptosis induction of glioma cells. Furthermore, the anti-glioma effect of TSN was exerted through the inhibition of the PI3K/Akt/mTOR signaling pathways as demonstrated by western blotting analysis. In addition, the effects of TSN on glioma cell viability, apoptosis, cell cycle arrest, migration, and invasion were reversed by 740Y-P, a PI3K activator. Finally, the mouse xenograft model confirmed the suppressive effect of TSN on tumor growth in vivo. Conclusion: Our results suggest that TSN is a promising chemotherapeutic drug for patients with glioma.
Different prognostic effect of surgery, radiation and chemotherapy in pediatric medulloblastoma less and over three years old: A Surveillance, Epidemiology, and End Results (SEER) analysis
Authors: Deng Zhong , Wang Yichang , Li Xixi , Tang Hongxing , Yang Jia , Wang Tuo
Published: June 2021

Introduction

To clarify the prognostic value of extent of surgical resection, radiation and chemotherapy in pediatric medulloblastoma patients < 3 years old and ≥ 3 years old.
Methods

We used the Surveillance, Epidemiology, and End Results program to identify 1,495 pediatric patients diagnosed between 1973 and 2016 with medulloblastoma. Patients with incomplete or unknown clinical information were excluded. Basic characteristics between patients < 3 years old and ≥ 3 years old were compared. Then, we used Cox regression to investigate the impact of extent of surgical resection, radiation and chemotherapy on patient outcome.
Results

Gross total resection only significantly improved patient outcome in those ≥ 3 years old, and radiation independently correlated to better OS and PFS in patients ≥ 3 years old (all p < 0.05). However, chemotherapy only benefited patient outcome in those < 3 years old (all p < 0.05). Furthermore, in those ≥ 3 years old patients underwent surgical procedures, radiation alone confer survival benefit only in those received gross total resection (p < 0.05) but not in partial resection or biopsy (p > 0.05). Notably, adjuvant radiation plus chemotherapy largely improved patient survival independent of extent of resection (p < 0.05).
Conclusions

The extent of resection should be differentially considered and applied between pediatric medulloblastoma patients < 3 years old and ≥ 3 years old, so are the adjuvant radio- and chemo- therapies.
A Prognostic lncRNA Signature Associated with Lipid Metabolism in Glioma
Authors: Duan Weiwei , Li Chen , Cao Hui , Wen ZhiPeng , He Shiqing , Cheng Quan , Xia Zhiwei
Published: June 2021

Background: Long noncoding RNAs (lncRNAs) are promising cancer biomarkers and therapeutic targets . And lipid metabolism reprogramming is a trait of cancer metabolism. However, the relationship between lncRNAs and lipid metabolism and their prognostic value are still unclear in glioma. Hence, we screened for prognostic lncRNAs associated with lipid metabolism and explored their potential biological functions and effects on glioma. Methods: The glioma data were obtained from TCGA and CGGA databases. Correlation analysis was used to identify the lncRNAs associated with lipid metabolism . The Cox and LASSO regression analysis were adopted to find prognostic lncRNAs, and further established ceRNA network, clustering and risk score models. CNV and somatic mutation data were used to explore the correlation between risk score and genomic alterations. GSVA and GSEA was adopted to reveal the potential biological functions of prognostic lncRNAs. The abundance of 22 immune cells was inferred by CIBERSORT algorithm . The TIDE algorithm and GDSC database were used to predict the patient's response to immunotherapy and chemotherapy, respectively. Human glioma cell lines were used for further experimental validation. CCK-8 and colony forming assays were adopted to evaluate the cell viability. The cell proliferation was detected by EdU assay. Transwell assay was used to evaluate the ability of cell invasion and migration. Results: A total of twenty prognostic lncRNAs associated with lipid metabolism were found, and a prognostic lncRNA signature was established. A high risk-score suggested a poor prognosis , more malignant clinicopathological and genomic aberrations features. The risk score was also an independent prognos tic factor. The high-risk patients were more likely to benefit from anti-PD1 treatment. The biological function of signature lncRNAs was mainly to regulate the biosynthesis and transportation of lipid (especially the fatty acid). Among signature lncRNAs, LINC01614 was associated with prognosis, genomic aberrations characteristics, m6A methylation modification, immune infiltration status, and chemotherapy response of patients with glioma. In vitro experiments, silencing the expression of LINC01614 could inhibit the viability, migration , and proliferation of glioma cells. Conclusions: A prognostic lncRNA signature containing twenty lncRNAs associated with lipid metabolism was established in glioma. The signature lncRNAs play an important role in the development of glioma by regulating lipid biosynthesis and transportation. Our study also provides a new perspective for understanding the lipid metabolism and the biological role of lncRNAs in glioma.
Optimization of ultrasonically welded High density polyethylene with Medium density polyethylene
Authors: Asokan Vignesh , Prasanna Venkat
Published: June 2021

Ultrasonic welding is a mechanical system whereby high-recurrence ultrasonic acoustic vibrations are privately connected to workpieces being held together compelled to make a strong state weld. It is usually utilized for plastics, and particularly for joining disparate materials. The point of the undertaking is to examine the quality of weld when unique materials are welded together. The sort of weld will rely upon an on-hold time, weld time, weight, and recurrence. Materials utilized will be HDPE (High Density Polyethylene) and a blend of HDPE-LDPE which is termed as MDPE (Medium density polyethylene). Diverse materials have distinctive properties and thus making a joint with wanted properties will give a better outcome. If one material has properties like better elasticity, pressure quality and other material have properties like pliability and flexibility and so forth then the blend of these materials will have properties of both the materials and when these kinds of materials are welded ultrasonically, they give a better outcome. Subsequently we will get a material which will give better quality with ease. Likewise, the material will be increasingly adaptable.
Estimating the pre- and post-diagnosis costs of tuberculosis care for adults in Karachi, Pakistan: Household economic impact and strategies for meeting the costs
Authors: Razzaq Shama , Zahidie Aysha , Fatmi Zafar
Published: June 2021

Background

Despite of free TB care in Pakistan, patients still have to bear high costs which push them more into poverty. This study estimated the types of costs households bear for TB care, and coping mechanisms used for bearing TB expenditures among adults ≥ 18 years in Karachi, Pakistan.
Methods

A total of 516 TB patients with completion of at least one month intensive treatment were recruited from four public sector hospitals in Karachi, Pakistan. A standardized questionnaire to estimate patient's costs was administered. Direct medical and non-medical costs incurred as out-of-pocket and indirect costs (loss of income) during pre-diagnostic, diagnostic, treatment and hospitalization phase were estimated.
Results

Out of 516 participants, 52.1% were female with a mean age of 32.4 (± 13.7) years. The median costs per patient borne during the pre-diagnostic, diagnostic, treatment and hospitalization was estimated at USD63.8/ PKR7377, USD24/ PKR2755, USD10.5/ PKR1217 and USD349.0/ PKR40300, respectively. The total household median costs was estimated at USD129.2/ PKR14919 per patient. The median indirect costs were estimated at USD52.0/ PKR5950 per patient. First point of care was a private provider by 54.1% of patients, 36% attended public service, 5% and 4.1% went to dispensary and pharmacy, respectively.
Conclusion

TB patients bear substantial out-of-pocket costs before they are enrolled in publically funded TB program. There should be provision of transport and food vouchers, also health insurance for in-patient treatment. This advocates a critical investigation into an existing financial support network for TB patients in Pakistan with an eye towards easing the burden.
Design of decentralized adaptive control approach for large-scale nonlinear systems subjected to input delays under prescribed performance
Authors: Han Yu-Qun
Published: June 2021

For the first time, the issue of input delays and prescribed performance control is investigated in the same framework for large-scale nonlinear systems in this study, and a original adaptive decentralized control method is proposed take advantage of multi-dimensional Taylor network (MTN) method. Firstly, the problem of input delays is solved by introducing new variables, and a new form of coordinate transformation is introduced before controller design, which simplified the control system. Secondly, the problem of prescribed performance control is coped with by integrating the idea of prescribed performance into the Lyapunov functions of first step of backstepping of each subsystem. Thirdly, MTNs are employed to evaluate the combination of unknown functions, and then a decentralized MTN-based adaptive control scheme is developed by way of backstepping technology. The theoretical analysis indicates that the proposed control scheme can implement the expected tracking goals under the condition of meeting the prescribed performance control. Finally, one numerical example is given to show the validity and rationality of the proposed control method.
Exercise as an Add-on Strategy for the Treatment of Bipolar Disorder: Systematic Review and Meta-analysis Protocol
Authors: Rocca Andrey Rocha , Filho José Celio da Rocha Lima , Pesconi Rafael Barbosa Roque , Alves Déborah Alvim Monteiro Batista , Pereira João Victor Coutinho , Pontes Kaio Henrique Oliveira , Souza Pedro Vinicyus Novais , Ramos Marina Matos , Campos Rodolfo Nunes
Published: June 2021

Background: Bipolar disorder (BD) is a severe, recurrent and chronic disorder associated with cognitive impairment, reduction in quality of life and substantially reduction in psychosocial functioning. It presents high rates of comorbidity with cardiovascular and cerebrovascular diseases, diabetes and metabolic syndrome. Individuals with bipolar disorder need to focus their attention and treatment on mental and physical health. Physical exercise is often recommended in bipolar disorder, based on extrapolation from the major depressive disorder literature, theory and clinical expertise. However, studies tend to exclude individuals with BD or make no distinction between diagnostic groups, which leads to heterogeneity and difficulty in generalizing the results. The aim of this review is to evaluate the role of physical exercise as an intervention in bipolar disorder treatment. Method: The study populations must be humans, aged 18 years or older, with a clinical diagnosis of Bipolar Disorder (BD) according to a recognised widely-used diagnostic classification approach, confirmed with a structured interview. We will evaluate two main outcomes (mood symptoms improvement and functioning) and an additional outcome (prevention of relapse/recurrence). The search strategy will be based on the PICOS framework, using medical subject headings, on the following databases: MEDLINE (via Pubmed), EMBASE, CENTRAL, SPORTDiscus (via EBSCO), PsycINFO (via APA) and OpenGrey Repository. Selection and data collection process will be carried out by two authors, independently. Risk of bias and quality of evidence will be graded acording ROB-2 and GRADE. We will present a narrative and quantitative synthesis of the results from the included studies. Regarding quantitative data, we will extract means (M) and standard deviations (SD), when available, to calculate the standardised mean difference (SMD). Effects size will be calculated using SMD and 95% confidence interval and heterogeneity will be assessed. Subgroup analysis will be conducted to explore heterogeneity across studies depending on quality and quantity of the data extracted.Discussion: To date, there wasn't a systematic review with only randomized controlled trials on effects of physical activity on BD. Because of this, we will conduct this systematic review trying to estabilish the effects of exercise on mood, functionality and prevention of relapse.Registration: submitted
Community Dynamics of Fungi During the Progression of Human Non-Small-Cell Lung Cancer
Authors: Zhao Yiming , Yi Junqi , Xiang Juanjuan , Jia Wei , Chen Anqi , Chen Liyu , Zheng Leliang , Zhou Wen , Wu Minghua , Yu Zheng , Tang Jingqun
Published: June 2021

Background: Lung cancer is the most common cancer worldwide. The correlation between lung microbiota dysbiosis and lung cancer has been explored. However, the characteristics of the lung mycobiome in lung cancer patients has not been fully examined. In this study, we performed metagenomic sequencing on bronchoalveolar lavage (BAL) from 24 patients with non-small-cell lung cancer (NSCLC) and 14 non-cancerous controls with benign mass. Results: We observed greater fungal diversity and connectivity in NSCLC patients compared to non-cancer controls. Network analysis revealed that the sum of degrees in NSCLC was more numerous, suggesting the connections of fungal communities were more active. The community networks were reconstructed in 4 main ecological modules. The module and network hubs included Vanderwaltozyma polyspora, Apiotrichum porosum, Lobosporangium transversal, Capronia epimyces and Pseudomicrostroma glucosiphilum. Random forest analysis and DESeq2 were performed to screen out distinct species in two seperate groups and 3 fungi Alternaria arborescens, Eremoyces bilateralis and Malassezia restricta were identified as potential diagnosis biomarkers for NSCLC patients. In these 3 fungi, the relative abundance of Alternaria arborescens was gradually increasing as NSCLC progressed. Conclusions: Taken together, our study innovatively proposes that changes in the structure of fungal communities in lung cancer may be closely related to lung carcinogenesis as well as its progression and the distinct species listed above could be used to detect and monitor NSCLC.
Determinants of the Postprandial Triglyceride Response to a High-fat Meal in Healthy Overweight and Obese Adults.
Authors: Wilson Stephanie M , Maes Adam P. , Yeoman Carl J. , Walk Seth T. , Miles Mary P.
Published: June 2021

Background: Dyslipidemia is a feature of impaired metabolic health in conjunction with impaired glucose metabolism and central obesity. However, the contribution of factors to postprandial lipemia in healthy but metabolically at-risk adults is not well understood. We investigated the collective contribution of several physiologic and lifestyle factors to postprandial triglyceride (TG) response to a high-fat meal in healthy, overweight and obese adults. Methods: Overweight and obese adults (n=35) underwent a high-fat meal challenge with blood sampled at fasting and hourly in the 4-hour postprandial period after a breakfast containing 50 grams fat. Incremental area under the curve and postprandial magnitude for TG were calculated and data analyzed using a linear model with physiologic and lifestyle characteristics as explanatory variables. Model reduction was used to assess which explanatory variables contributed most to the postprandial TG response.Results: TG responses to a high-fat meal were variable between individuals, with approximately 57% of participants exceeded the nonfasting threshold for hypertriglyceridemia. Visceral adiposity was the strongest predictor of TG iAUC (β=0.53, p=0.01), followed by aerobic exercise frequency (β=0.31, p=0.05), insulin resistance based on HOMA-IR (β=0.30, p=0.04), and relative exercise intensity at which substrate utilization crossover occurred (β=0.05, p=0.04). For postprandial TG magnitude, visceral adiposity was a strong predictor (β=0.43, p<0.001) followed by aerobic exercise frequency (β=0.23, p=0.01), and exercise intensity for substrate utilization crossover (β=0.53, p=0.01). Conclusions: Postprandial TG responses to a high-fat meal was partially explained by several physiologic and lifestyle characteristics, including visceral adiposity, insulin resistance, aerobic exercise frequency, and relative substrate utilization crossover during exercise. Trial Registration: ClinicalTrials.gov, NCT04128839, Registered 16 October 2019 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04128839
The Landing Error Scoring System Real-Time (LESS-RT) As a Predictive Tool for Overuse Injuries and Ankle Sprain: A Historical Cohort Study.
Authors: SCHWARTZ OREN , Talmy Tomer , Olsen Cara H , Dudkiewicz Israel
Published: June 2021

Background:Overuse injuries and ankle sprains are commonly sustained by soldiers and athletes during conditioning programs and may have significant ramifications on both individuals and organizations. The Landing Error Scoring System (LESS), and its expedited real-time version (LESS-RT) were developed to assess risk for ACL injuries, but have never been used to assess overuse or ankle injuries which are of high priority in a military or athletic settings. The purpose of this study was to evaluate predictive value of The Landing Error Scoring System Real-Time (LESS-RT) for overuse injuries of the lower limb and ankle sprains among Israel Defense Forces (IDF) combat soldiers.Methods: A historical cohort study was conducted on 2,474 IDF combat soldiers from different service units with a wide range of fitness levels and training requirements. The predictive variable was LESS-RT score and the outcome variables were the incidence of overuse injuries and ankle sprains. Receiver operator characteristic curves were used to assess the predictive value of LESS-RT for both outcomes. Results: The AUC for overuse injuries and ankle sprains were 0.537, 95% CI 0.514-0.560 and 0.523, 95% CI 0.491-0.556 respectively. Conclusions:The results of this study shows no predictive value of LESS-RT score for both overuse injuries of the lower limb and ankle sprains.
Examination of Patient Profiles Admitted to the Paediatric Emergency According to Various Variables
Authors: YUKSEL Ayfer
Published: June 2021

Purpose: The aim is to examine the applications to the paediatric emergency service of Foundation University Hospital in Ankara according to variables: gender, age, season of application, diagnosis, number of consultations and hospitalizations, and triage codes. Materials and methods: The research is a retrospective descriptive study. The data of patients admitted to the paediatric emergency department of a hospital in Ankara between 01.08.2017-31.07.2018 were obtained (n=16383). Frequency, percentages, cross table, and chi-square test were used for comparison. Findings: 0% of patients: very urgent application, 19%: urgent and 81%: non-urgent. The most common first three diagnoses: “unknown origin fever”, “cough”, "nausea and vomiting”. The 0-28 days age group had the lowest number of applications with 5% and had the highest emergency triage status with 66.5%; and the 19 months-5 years age group had the highest number of applications with 49% and had the lowest emergency triage rate with 12.8%.Conclusion: The reasons for applying to PES may differ according to contextual variables and providing parents with information from reliable sources may reduce unnecessary anxiety and emergency service admissions. There should be strengthened primary health care services and referral system to maintain high-quality emergency services.
An assessment of canine ectoparasiticide administration compliance in the United States based on timing of ectoparasiticide purchases recorded in veterinary hospital transactions.
Authors: Lavan Robert Philip , Normile Dorothy , Husain Imran , Singh Amita , Armstrong Robert , Heaney Kathleen
Published: June 2021

Background: This study evaluated the timing of dog owner ectoparasiticide purchases to estimate administration compliance and assess the consequent impact of dose purchase gaps on the proportion of time that dogs are protected over a 12-month period. Methods: Ectoparasiticide purchase transactions over a 12-month period were evaluated for dogs from 626 U.S. veterinary hospitals to determine dose purchase timing and identify consequent gaps between dose administration. Orally administered prescription ectoparasitic medications with active ingredients from the isoxazoline family (afoxolaner, fluralaner, lotilaner, or sarolaner) are included in the analysis. A period was calculated for each of the four isoxazoline-containing medications that represented the duration of protection provided by two doses of ectoparasiticide plus the average gap between these two doses. The maximum percentage of time possible for ectoparasiticide protection for this aggregate period was then calculated for each active. Results: Ectoparasiticide transaction records were analyzed for 506,637 dogs. Of these, 43% of dog owners purchased just one dose over the 12 months. If a dog owner purchased more than one dose, then the timing of these transactions could create a time gap between the completion of ectoparasite protection from the first dose and onset of protection from the subsequent purchase and administration of the second dose. Such gaps were observed in purchases made by 31-65% of dog owners depending on the selected active ingredient and number of doses. The average gap duration between dose purchases was calculated for all possible dose combinations over 12 months of ectoparasite protection. Time gaps between the first and second doses are as follows: for sarolaner (20.3 weeks), afoxolaner (12.9 weeks), fluralaner (12.8 weeks), and lotilaner (8.9 weeks). The proportion of time when protection was provided during the aggregate period between administration of the first and second doses was fluralaner 65%, lotilaner 49%, afoxolaner 40,% and sarolaner 30%. Conclusions: Dog owner ectoparasiticide purchase transactions show that there are time gaps between doses leading to reduced ectoparasite protection. The longer re-administration interval of fluralaner, which results from its extended duration, results in dog owners gaining the greatest proportion of ectoparasite protection time compared with shorter-acting monthly re-treatment medications.
Diffuse Midline Glioma with H3-K27M Mutation: A Rare Case with GFAP-positive Anucleate Whorled Patterns
Authors: Wang Yi-Hua , Gu Jian , Yu Juan-Han , Fu Lin , Li Qing-Chang , Qiu Xue-Shan , Wang En-Hua
Published: June 2021

Background: Diffuse midline glioma with H3-K27M mutation is a new tumor type in the 2016 WHO classification of tumors of the central nervous system, with predominantly astrocytic differentiation and is characterized by K27M mutation in either H3F3A/-HIST1H3B/C. It occurs at the midline of the CNS. It is mainly found in children, and adult cases are relatively rare . Although its histopathological features have been widely described, GFAP-positive anucleate whorled patterns have not been reported to the best of our knowledge. Hence, we have reported this unusual case.Case presentation：A woman presented with complaints of walking instability. MRI showed a mass shadow of isometric T1 and slightly longer T2 with mild mixed signals in the third ventricle of the suprasellar region, about 3.4 x 2.5 x 3.4 cm in size. The enhanced scan showed that the lesion was irregular and annular, with a clear edge. The lesion had spread to the right lateral ventricle, which dilated the ventricular system, especially the right lateral ventricle. Furthermore, the lamellar long T2 signal was seen in bilateral paraventricular white matter, the midline structure had shifted to the left, and the corpus callosum was thinner. Radiological findings suggested ependymoma. Subtotal resection craniotomy was performed. After surgery, the patient was routinely treated with temozolomide for chemotherapy and synchronous radiotherapy (Dt=60 Gy/30f). It has been 11 months now, and the patient is living well.Result: We described an extremely rare case of diffuse midline glioma, H3-K27M mutation with GFAP-positive anucleate whorled patterns. Conclusions: This case report provides information on the microscopic morphological features of diffuse midline glioma with H3K27M mutation, which can help pathologists to make a definitive diagnosis of this tumor.
CircFNDC3B inhibits cell growth in abdominal aortic aneurysm by targeting the miR-1270/PDCD10 axis
Authors: Deng Baoping , Wei Yue , Zhang Jinfeng , Zeng Na , He Yulan , Zeng Qiaoli , Zou Dehua , Guo Runmin , Xu Jing
Published: June 2021

BackgroudIn certain cancers, circRNA fibronectin type III domain containing 3B (circFNDC3B) may serve as a specific target for the treatment. However, the role and underlying regulatory mechanisms of circFNDC3B in abdominal aortic aneurysm (AAA) remain unknown.MaterialsCircFNDC3B expression in AAA and normal tissues were assessed by qRT-PCR. The biological functions of circFNDC3B were evaluated by MTT, flow cytometry and Caspase-3 activity assays. Furthermore, the molecular mechanism of circFNDC3B was demonstrated by RNA immunoprecipitation (RIP), dual-luciferase reporter assay, western blotting, qRT-PCR and rescue experiments. ResultsWe found that the expression of circFNDC3B was significantly upregulated in AAA clinical specimens. Functionally, overexpression of circFNDC3B inhibited vascular smooth muscle cell (VSMC) proliferation and induced apoptosis in vitro, yet, knockdown of circFNDC3B had the opposite effects. Mechanistically, circFNDC3B upregulated the expression of programmed cell death 10 (PDCD10) by acting as a molecular sponge for miR-1270. Notably, forced expression of PDCD10 countervailed the impact of circFNDC3B knockdown on AAA biological processes.ConclusionsOur data indicated that circFNDC3B promoted the progression of AAA by targeting the miR-1270/PDCD10 pathway, and may be a potential therapeutic target in the treatment of AAA.
Assessment of knowledge, attitude, and practice towards COVID 19 pandemic prevention among undergraduate student of Bule Hora University, southern Ethiopia
Authors: Asefa Lechisa
Published: June 2021

Aim: The aim of this study was to assess the knowledge, attitudes, and practice of Bule Hora university undergraduate student towards COVID-19 pandemic prevention, October 2020Methods and materials The KAP of Bule Hora University undergraduate students were assessed using a cross-sectional study design. As a data collection tool, a structured questionnaire was used. Epi-Data version 4.5 was used to enter the data, and SPSS version 25 was used to analyze it. The Knowledge, Attitude and practice (KAP) of student was analyzed by using likert scale analysis and multinomial logistic regression analysis were used to analysis the association between dependent and independent variables The results: -From total study participants, 75% and 69.8% of them have adequate knowledge and positive attitude on COVID-19 symptoms, prevention and control measures. 92% of respondents Known as COVID-19 can be transmitted directly through contact with infected surfaces. Half of the participants have adequate practice to prevent and control COVID-19 disease. The multinomial logistic regression show that residence (P=0.005, AOR=2. 48(1.296-5.803)) and income (P=0.004, AOR= 2.633(1.49-5.350)) has an association with Knowledge and attitude of students.Conclusion: - the majority of undergraduate students of the Bule Hora University had well knowledge and more than half of them had a positive attitude about COVID-19 pandemic prevention and control. However, they have low practice to prevent COVI-19 pandemic
Meeting UK heat demands in zero emission renewable energy systems using storage and interconnectors
Authors: Cassarino Tiziano Gallo , Barrett Mark
Published: June 2021

With over a third of the United Kingdom's greenhouse gas emissions, decarbonising heat is key to achieving the Government's net-zero target by 2050. Here, we simulate high renewable zero-emission energy system architectures with heat supply based on the major options of district heating, heat pumps, and electrolytic hydrogen boilers. We adopt a novel whole system modelling approach that combines meteorology-driven hourly simulations of demand and supply with storage, flexible technologies, and interconnections on the European scale. Our results show that systems with heat supply based on consumer or district heat pumps require about four times less electricity per unit of heat, with a heat cost about half of that from electrolytic hydrogen boilers. Furthermore, we compare trade-offs between investment in different infrastructure components. For example, we find that, compared to the reference scenario, increasing renewable capacity by 33%, or interconnections by 200%, can lower system storage capacity by up to 50%.
Prüfungsrecht: Die Begründung von Prüfungsentscheiden
Authors: Zünd Rafael
Published: June 2021

Im Prüfungsrecht ist die Begründung der Leistungsbewertung von entscheidender Bedeutung. Erst die Begründung erlaubt es dem Prüfling und der Beschwerdeinstanz die Bewertung nachzuvollziehen. Art. 29 Abs. 2 BV stellt die Mindestgarantie bezüglich Anforderungen an die Begründung dar. Grosse Teile der Rechtsprechung erachten dabei die schlichte Notenbekanntgabe im Verwaltungsverfahren als ausreichend. Gemäss dieser Praxis reicht es aus, wenn die nachvollziehbare Begründung im Beschwerdeverfahren nachgeschoben wird und der Prüfling in einem zweiten Schriftenwechsel dazu Stellung nehmen kann. Der Autor setzt sich sowohl mit den Anforderungen an die Begründung als auch mit den Rechtsfolgen einer verletzten Begründungspflicht auseinander. Zudem versucht er aufzuzeigen, weshalb von Prüfungsbehörden im Verwaltungsverfahren zumindest eine summarische Begründung verlangt werden muss. Bei mündlichen und praktischen Prüfungen sollte die Rechtsprechung sodann eine Aufzeichnungs-/Protokollierungspflicht aus Art. 29 Abs. 2 BV ableiten.

--

En droit des examens, il est décisif que l’évaluation des performances du candidat soit motivée. En effet, seule la motivation permet au candidat, et à l'instance de recours, de saisir les tenants et les aboutissants de l'évaluation. L'art. 29 al. 2 Cst. constitue la garantie minimale en ce qui concerne les exigences en matière de motivation. Une grande partie de la jurisprudence considère que la simple communication des notes est suffisante dans le cadre d’une procédure administrative. Selon cette pratique, il suffit qu’un exposé compréhensible des motifs soit ajouté dans la procédure d'appel et que le candidat puisse se déterminer à ce sujet lors d’un second échange d’écritures. Dans son article, l’auteur traite des exigences en matière de motivation, ainsi que des conséquences juridiques d'une violation de l'obligation de motivation. En outre, il démontre en quoi une motivation, au moins sommaire, doit être exigée par les autorités d'examen dans les procédures administratives. S’agissant des examens oraux et pratiques, la jurisprudence devrait déduire de l'art. 29 al. 2 Cst. une obligation d'enregistrer/de dresser un procès-verbal de l’épreuve.
INDIAN OCEAN 21 WORLDS WORLD POLITICS CENTER
Authors:   M.Phil. Research Scholar, Center for Deendayal Upadhyay Studies,CUHP, Sapta Sindhu Parisar Dehra kangra-177101(H.P.)., Kumar Amar , a Vishal ,   M.Phil. Research Scholar, Center for Deendayal Upadhyay Studies,CUHP, Sapta Sindhu Parisar Dehra kangra-177101(H.P.).
Published: June 2021

The life base of the South Asian states is the Indian Ocean. This ocean depends on the geographical security, sovereignty, development, destruction, life of these states on this natural heritage. The only ocean in the world whose name is named after a country (India, Hind). It has many resources by providing these states and the world. 1971 Menyhdomhanvicharokatkravdeknekomilaawrakaakyhkshetranykshetronsemhtwpuarnhogyaksandhion, Sanyabyas, Senakitanati, Ityadikiakaakjdilggiawrajayhkshetr 21 Visdimenvishwarajnitikakendrabngyahabiswkimahashktionamerika, China, France, Russia, China, Britain, Japanupsthitiyhdekijasktihakjisnemulhindmahasagrdeshonkewyprikhiton, sovereignty, Videshnitikelisnktutpnkrdiahakpunjiwadawrsamywadkahotatkravhindmahasagrkishantikobngkrrhaha.
FINITE VOLUME METHODDISCRETIZATION OF MODIFIEDNAVIER-STOKES EQUATION
Authors: Oduor Michael , Oleche Paul , Amakobe James Hagai
Published: June 2021

This study has come up with a numerical scheme that arises from finite volume discretizationof Modified Navier-Stokes Equation.Modified Navier-Stokes Equation in the x-z axis was coupled with continuity equation to obtain the Pressure Equation. Using the pressure equation, pressure field can bedetermined in each control volume on a staggered grid.
BEACH FLORA ALONG THE COAST OF GAHIRMATHA MARINE WILDLIFE SANCTUARY (ODISHA), INDIA
Authors:   Mangrove Forest Division (Wildlife) Rajnagar, Kendrapara, Odisha., Kumar Nayak Prasanna , Ranjan Dash Bikash ,   Mangrove Forest Division (Wildlife) Rajnagar, Kendrapara, Odisha., Mahapatra Manoj ,   Regional Chief Conservator of Forests, Bhubaneswar Circle, Bhubaneswar, Odisha.
Published: June 2021

Beach flora along the maritime ecosystem is very sensitive and fragile in nature. Studies on floral species composition and their ecological role in the sensitive coastal and marine ecosystem of Indian coast in general and coast of Odisha in particular are scanty. Keeping in view, a detailed survey along the coast of Gahirmatha beach in Kendrapara district, Odisha was conducted. A total of 67 species under 62 genera belonging to 36 families of flowering plants were collected and identified at different localities from the shoreline towards inland of the coastline. The floral composition of sandy beach of Gahirmatha coast was found to be rich and diverse. The sensitive ecosystem need to be protected from habitat degradation in order to provide congenial niche for the diverse beach elements that caters the ecological functioning and also supporting the associated floral as well as faunal assemblages in the area.
HIGHER SECONDARY SCHOOL STUDENTS PERCEPTION ABOUT ONLINE CLASSES DURING PANDEMIC WITH REFERENCE TO SELECTED SCHOOLS IN TIRUCHIRAPPALLI CITY
Authors:   Assistant Professor, Department of Business Administration, Holy Cross College (Autonomous), Tiruchirappalli -02, Tamilnadu, India., Arokia Punitha S.
Published: June 2021

The Education system is changing rapidly with all schools preferring online learning platforms to enhance the students learning experience. Majority of the educational institution continued their online classes immediately realising the situation. This study was undertaken to know the students perception about the online classes for during COVID -19 pandemic in Tiruchirapalli city. Primary and Secondary data collected from respondents will be divided into independent variables and dependent variables. These independent variables are conceptualized by using a set of 5-point Likert scale statements to measure the students perception about online classes. Both the variables are supported by students perception about online classes. The online classes became the new normal for most school and college students, the cost of data has been another digital obstacle to surmount even for those with access to smartphones and internet connectivity. The government must introduce policies or an ordinance ensuring universal access to the internet for students stemming from which more systemic support could be offered.
Factors influencing the formation of consumer engagement and consumer satisfaction with e-learning activities
Authors: Santoso Singgih
Published: June 2021

The COVID-19 pandemic that plagued the world has resulted in many e-learning software that drove virtual learning activities to jump sharply and began to replace face-to-face meetings. This paper aims to find out the influence of digital readiness, technical and information quality, instructor quality, e-learning adoption and attitude on consumer engagement, and consumer satisfaction with e-learning performance. The study was conducted in the form of a quantitative survey at Duta Wacana Christian University in the Special Region of Yogyakarta, Indonesia, over the period from June 2020 to September 2020. The study sample using the purposive random sampling technique consisted of 175 students as respondents. Various statistical methods, including descriptive and structural equation modeling, were used to analyze the data and test the hypotheses of the model. Key findings were that there is a statistically direct impact of digital readiness, technical and information quality, e-learning adoption and attitude, and instructor quality on consumer engagement, and thus consumer engagement influences consumer satisfaction positively and significantly. With these results, tutorial activities need to be implemented for the use of popular e-learning software and related technological literacy, because the need for e-learning software will be even more massive in the future.
AVALIAÇÃO DA ESTRUTURA ELETRÔNICA DA FASE MONOCLINICA DO ÓXIDO DE NIÓBIO COM BASE NO USO DE DIFERENTES FUNCIONAIS DE DENSIDADE
Authors: Ody Kamila , Jesus João , Cava Carlos , Albuquerque Anderson , Maia Ary , Sambrano Julio , Porta Felipe
Published: June 2021

ASSESSMENT OF THE ELECTRONIC STRUCTURE OF THE MONOCLINIC PHASE OF NIOBIUM OXIDE BASED ON THE USE OF DIFFERENT DENSITY FUNCTIONALS. Niobium oxides, Nb2O5, are considered semiconductor materials with very attractive physical and chemical properties for applications in many areas, such as catalysis, sensors, medical, aerospace, etc. Especially, the characterization of Nb2O5-based nanostructures with monoclinic structure has received much attention in recent years. However, despite the great importance of this system, some of its fundamentals properties are still not fully understood. Hence, this work aims to apply the theoretical methodologies through Density Functional Theory (DFT) calculations in periodic models based on the use of different density functionals (like B1WC, B3PW, B3LYP, PBE0, PBESOL0, SOGGAXC, and WC1LYP) to investigate the physical and chemical properties of the monoclinic structure of Nb2O5. The band structures, energy bandgap, density of state, and vibrational properties, as well as order-disorder effects on the monoclinic structure of Nb2O5 are investigated in this study. Our theoretical results show a better agreement with experimental data for the B3LYP functional and hence lead to new perspectives on the deeper physicochemical understanding of the monoclinic Nb2O5. From these computational tools, it is possible to unravel the relations between structure and properties, which may contribute to the future development of new devices and applications based on these materials.
pH-RESPONSIVE WOOD SLICES FOR THE CONTINUOUS SEPARATION OF LIGHT OIL/WATER/HEAVY OIL TRIPHASE MIXTURES
Authors: Zhou Yanbiao , Qua Kaige , Zhang Lihui , La Ming
Published: June 2021

Light oil/water/heavy oil triphase mixtures are common in industrial wastewater, while nearly all separation materials with superwettability can only separate biphase mixtures of light oil/water or/and heavy oil/water. Here, a balsa wood slice with superhydrophilic/superoleophilic property in air was fabricated by a blade-cutting and ethanol-treating process. Therefore, the slice could be dually prewetted with both water and oil and thus showed underwater superoleophobic and underoil superhydrophobic properties without any further chemical modification. Such a slice showed underoil superhydrophobicity in nonbasic environment while transition into underoil superhydrophilicity under basic condition. Combining with the porous structure possessed by wood designed to transport liquids, this superwettability of the treated wood slice could be leveraged in the continuous separation of light oil/water/heavy oil triphase mixtures only driven by gravity with a high permeation flux and separation efficiency. After each separation, the slice was easily recovered by washing with acidic solution, and it could be recycled up to 15 times without any loss of pH responsibility. During repeated cycling separation, the slice exhibited excellent separation stability.
(DES)CONSTRUINDO A METABOLÔMICA EM PRODUTOS NATURAIS: UM CONVITE A DISCUSSÃO
Authors: Borges Ricardo , Resende João
Published: June 2021

DECONSTRUCTING METABOLOMICS WITHIN NATURAL PRODUCTS: AN INVITATION FOR A DISCUSSION. The metabolomics approach is widespread and accepted in several lines within life sciences. However, much of what has been called metabolomics could be better defined as a comparison study, regardless of its purpose. Metabolomics finds its definition in the understanding of biological properties and effects on a given organism. In any case, the tools used in metabolomics are undoubtfully useful and should be used in natural products studies, both those already established and those that are under development. Natural products research is in a continuous process of evolution to become a discipline driven by multivariate data with a solid influence of “omic” technologies
Expression of Concern: Fuzzy-probabilistic modeling the flood characteristics using bivariate frequency analysis and α-cut decomposition
Authors: Sun Xiaozhou , Khayatnezhad Majid
Published: June 2021

Water allocation in agricultural lands, optimal design of hydraulic structures and climatic phenomena are the events in water management science that face hydrological uncertainties. The purpose of this study is to estimate the characteristics of surface runoff based on probabilistic and fuzzy analysis. Separation and generation of basic hydrological information, probabilistic modeling, fuzzy analysis, and optimization to achieve the solution were the main steps of the decision-making problem. Long-term hydrological data of the study area were collected, analyzed and used as a basis for the simulation model. In this study, a copula-based stochastic method was developed to deal with uncertainties related to rainfall and runoff characteristics as well as to address the nonlinear dependence between multiple random variables. The relationship between rainfall variables and flood characteristics was formulated through fuzzy set theory. The feasible domain of the fuzzy problem was searched using the non-dominated sorting genetic algorithm to find the optimal extreme points. The obtained solutions were used as a fuzzy response to calculate the flood of the Baghmalek plain in Khuzestan province in southwestern Iran. The results showed that the maximum model error occurred in predicting rainfall depth and flood volume, and the maximum rainfall rate and runoff flow could be calculated more accurately. Moreover, the developed fuzzy-probabilistic model was able to predict more than 90% of flood events within the defined fuzzy range.
Rapid and Green One-Pot Synthesis of Novel 2-(4-Hydroxy-2-oxo-2Hchromen- 3-yl)-2-(arylamino)-1H-indene-1,3(2H)-diones
Authors: Olyaei Abolfazl , Ghahremany Zahra , Sadeghpour Mahdieh
Published: June 2021

A green and efficient protocol was developed for the one-pot three-component synthesis of novel 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-dione derivatives by the reaction of 4-hydroxycoumarin, ninhydrin and aromatic amines in the presence of guanidine hydrochloride as an organocatalyst under solvent-free conditions. The present approach offers several advantages such as low cost, simple work-up, short reaction times, chromatography-free purification, high yields and greener conditions.