bluuebunny/crossref_metadata_2025 huggingface dataset:
Was the atrioventricular block similar in anterior and inferior ST-elevation myocardial infarction?
Authors: Santos H , Santos M , Almeida I , Miranda H , Sa C , Almeida S , Chin J , Sousa C , Almeida L
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

OnBehalf

Portuguese Registry of Acute Coronary Syndromes

Background

The presence of atrioventricular block (AVB) in ST-elevation myocardial infarction (STEMI) is more frequently registered when is identified in the inferior leads. However, AVB maybe occurs in anterior STEMI, yet the AVB and STEMI localization maybe had different implications.

Objective

Evaluate the impact and prognosis of AVB according to the STEMI localization.

Methods

Multicenter retrospective study, based on the Portuguese Registry of Acute Coronary Syndrome between 1/10/2010-3/05/2020. Patients were divided into two groups: A – patients with anterior STEMI, and B – patients with inferior STEMI. Were excluded patients without a previous cardiovascular history or clinical data regarding AVB occurrence. Logistic regression was performed to assess AVB as a prognostic marker in STEMI patients.

Results

From 32157 patients, was identified 462 with AVB, 72 in group A (15.6%) and 390 in group B (84.4%). Both groups were similar regarding gender (p = 0.710), age (p = 0.068), body mass index (p = 0.535), admitly directly to cat lab (p = 0.635), initial symptons until first medical contact (p = 0.561), smoker status (p = 0.483), diabetes mellitus (p = 0.331), coronary artery disease (p = 0.053), previous stroke (p = 0.332),  peripheral artery disease (p = 0.348), chronic kidney disease (p = 0.425), systolic blood pressure (p = 0.057), multivessel diasease (p = 0.235), new-onset of atrial fibrillation (p = 0.582), cardiac arrest (p = 0.062) and stroke complication (p = 0.685). Group B had higher left ventricular ejection fraction (LVEF) >50% (16.9 vs 60.7%, p < 0.001). On the other hand, group A had more arterial hypertension (79.7 vs 66.2%, p = 0.027), dislipidaemia (58.2 vs 54.4%, p = 0.038), heart rate at admission (81 ± 20 vs 59 ± 23, p < 0.001), Killip-Kimball class > I (45.7 vs 29.6%, p = 0.008), sinus rhythm at admission (84.5 vs 72.6%, p = 0.035), heart failure complication (65.3 vs 37.1%, p < 0.001), cardiogenic shock complication (42.3 vs 24.7%, p < 0.001), ACS mechanical complication (8.3 vs 3.1%, p = 0.047), sustained ventricular tachycardia during ACS hospitalization (19.4 vs 8.5%, p = 0.005) and hospitalization death (52.9 vs 44.7%, p < 0.001). Logistic regression revealed that AVB in inferior STEMI was a predictor of new-onset of atrial fibrillation (odds ratio (OR) 3.817, p = 0.038, confidence interval (CI) 1.123-12.975), with a R2 Nagelkerke 24.4. Also, revealed that AVB in anterior STEMI was a predictor of death (OR 0.111, p < 0.001, CI 0.034-0.366), with a R2 Nagelkerke 55.2.

Conclusions

AVB in inferior STEMI was a predictor of new-onset of atrial fibrillation and AVB in anterior STEMI was a predictor of death.
A novel variant in the SLC4A3 gene with high penetrance in a family with short QT Syndrome
Authors: Kovacs B , Graf U , Magyar I , Baehr L , Maspoli A , Duru F , Berger W , Saguner AM
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

Short QT syndrome (SQTS) is a rare, autosomal dominant disease causing sudden cardiac death (SCD). Current guidelines recommend genetic testing. Associated variants in KCNQ1, KCNH2, KCNJ2 and SLC4A3 genes have been reported.

Purpose

We report a family with a variant in the SLC4A3 gene with several presentations of SCD and high clinical penetrance of SQTS.

Methods

We performed a post-mortem genetic testing in the index patient in whom prior ECG was available. Subsequently, clinical and electrophysiological work-up and cascade screening (CS) of the detected suspected variant was carried out in available relatives.

Results

The index patient had suffered a SCD at the age of 17 (figure, upper panel, arrow). A previously registered ECG showed a shortened QTc of 340ms (figure, lower panel). Autopsy revealed no structural heart disease. Post-mortem genetic testing revealed variants in the LDB3, MYH7 and a novel heterozygous missense variant, p.(Ser1039Arg) also in the SLC4A3 gene. Although predictive bioinformatic algorithms (AlignGVGD, SIFT, MutationTaster, Polyphen2) showed conflicting classifications, family history was notable for SCD without post-mortem genetic work-up in three second degree relatives (figure, upper panel, patients 207, 208 and 305, age of death 33, 25 and 33 years respectively). CS was performed in first and second degree relatives of the index patient and was highly suggestive for disease association of the variant in the SLC4A3 gene with co-segregation in all clinically affected family members. Only one patient with the variant had a normal QTc (figure, upper panel, patient 202) of 407ms, however this patient was on regular QT-prolonging medication (risperidone and loperamide).

Conclusion

Genetic testing revealed a novel in the SLC4A3 gene, which was recently implicated in the pathogenesis of the SQTS. Although predictive bioinformatic algorithms yielded conflicting results, CS of family members suggests a likely pathogenicity (class IV) of the variant. Further CS or functional tests are necessary to establish causality. Abstract Figure. ECG of index patient and family tree
Sustained ventricular tachycardia as a predictor of major adverse cardiac events in acute coronary syndrome patients
Authors: Santos H , Almeida I , Miranda H , Santos M , Sa C , Chin J , Almeida S , Sousa C , Almeida L
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

OnBehalf

Portuguese Registry of Acute Coronary Syndromes

Background

Sustained ventricular tachycardia (VT) is a frequent rhythm disturbance during an ischemic event like acute coronary syndrome (ACS). VT was frequently associated with worse prognosis, then is expected, that its presence is related to a higher incidence of major adverse cardiac events (MACE).

Objective

Evaluate if sustained VT was a predictor of MACE in ACS hospitalized patients.

Methods

Multicenter retrospective study, based on the Portuguese Registry of ACS between 1/10/2010-4/09/2019. Patients were divided into two groups: A – patients without VT, and B – patients that presented VT on the hospitalization. VT was defined as a register or more of the VT with at least 30 seconds. Were excluded patients without a previous cardiovascular history or clinical data. MACE was defined as re-infarction, congestive heart failure, cardiogenic shock, a mechanical complication of myocardial infarction, completed atrioventricular block, sustained ventricular tachycardia, cardiac arrest, stroke and hospitalization death. Univariate logistic regression was performed to assess if VT in ACS patients was a predictor of MACE.

Results

A total of 29851 patients was analyze and 25725 had information regarding VT. From the group of patients that presented VT, 177 (1.1%) had re-infarction, 2415 (14.1%) had congestive heart failure, 816 (5.0%) had atrial fibrillation, 108 (0.7%) had a mechanical complication of myocardial infarction, 442 (2.7%) had completed atrioventricular block, 458 (2.8%) had cardiac arrest, 101 (0.6%) had stroke and 535 (3.3%) died. VT did not predict re-infarction (p = 0.071), mechanical complication of myocardial infarction (p = 0.979) and stroke (p = 0.500) in ACS hospitalized patients. Logistic regression revealed that VT in ACS patients was a predictor of congestive heart failure (odds ratio (OR) 2.304, p < 0.001, confidence interval (CI) 1.742-3.047), atrial fibrillation (OR 2.078, p < 0.001, CI 1.453-2.973), completed atrioventricular block (OR 1.831, p = 0.012, CI 1.145-2.928), cardiac arrest (OR 15.434, p < 0.001, CI 11.429-20.843) and hospitalization death (OR 6.472, p < 0.001, CI 4.484-9.342).

Conclusions

VT in ACS patients predict MACE, namely congestive heart failure, atrial fibrillation, completed atrioventricular block, cardiac rest and hospitalization death.
A Left sided site of origin is associated with adverse cardiovascular outcomes in patients with LV dysfunction undergoing PVC ablation
Authors: Penela D , Fernandez-Armentas J , Acosta J , Bisbal F , Jauregui B , Soto D , Aguinaga L , Acena M , Biagi A , De Sensi F , Ordonez A , Chauca A , Carreno J , Berruezo A
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

Epidemiological studies suggested that premature ventricular complexes (PVCs) are associated with cardiac mortality. But data are still inconclusive.

Aim

This study sought to analyze predictors of adverse outcomes in a population of patients with left ventricular (LV) systolic dysfunction who underwent PVC ablation.

Methods

135 consecutive patients [100 (74%) men, 59 +12 y.o.] with LV systolic dysfunction [LV ejection fraction (LVEF) <50%] and frequent PVCs who underwent PVC ablation were included in a multicenter prospective international register. Patients were followed-up at 6 and 12 months and annually thereafter. The last evaluation performed was considered the long-term follow-up (LTFUP) evaluation. Cardiac mortality and/or cardiac transplantation and/or admission for heart failure was considered the primary endpoint.

Results

82 (61%) patients had a left-sided PVC’s site of origin (LS-SOO), 51 (38%) had a right-sided SOO (RS-SOO) whereas SOO could not be determined in 2 (1%) patients. LS-SOO patients were older (61 ± 11 vs 52 ± 10, p < 0.001) more frequently men [71 (87%) vs 27 (53%), p < 0.001] with previous history of atrial fibrillation (AF) [14 (15%) vs 0, p = 0.001] and with a previously diagnosed structural heart disease (SHD) [43 (52%) vs 6 (11%), p < 0.001].

After a mean follow-up of 39 ± 21 months (range 24-94 months) there was a significant reduction in the PVC burden from 24 ± 13% at baseline to 4 ± 6% at LTFUP, p < 0.001; LVEF improved from 33 ± 8% at baseline to 41 ± 13% at LTFUP (p < 0.001) and NYHA class from 2.1 ± 0.6% to 1.4 ± 0.6% (p < 0.001); BNP levels decreased from 237 ± 231 pg/mL to 137 ± 185 pg/mL (p = 0.001). The primary end-point was reached in 10% patients (7 cardiac deaths, 1 cardiac transplantation and 5 heart failure admisions), 14,8% in LS-SOO and 1,9% in RS-SOO patients, log rank = 0.05 (Figure 1).

Conclusions

Among patients with LV dysfunction who underwent PVC ablation, those with LS-SOO were older and more frequently had AF and SHD. LS-SOO was associated with adverse cardiovascular outcomes. These findings suggest that PVCs with LS and RS-SOO should be considered as two different clinicals entities, with different prognostic values. Abstract Figure 1
Outcome of a modified sympathicotomy for cardiac neuromodulation of untreatable ventricular tachycardia
Authors: Cauti FM , Rossi P , Vannucci J , Polselli M , Rossi C , Iaia L , Mantovani S , Bruno K , Pugliese F , Quaglione R , Venuta F , Bianchi S , Anile M
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

OBJECTIVES This study aimed to describe the results of a modified sympathicotomy (uniportal VATs with stellate ganglion sparing) for cardiac sympathetic denervation (CSD) in the setting of untreatable ventricular tachycardia.

BACKGROUND. CSD, in patients with refractory ventricular tachycardia (VT), is comprehensively recognized as an important treatment option for patients with structural heart disease as well as congenital inherited arrhythmia syndrome. A recent case series demostrated  the feasibility of the modified technique.

METHODS We consecutively enrolled 8 patients with refractory VT. Baseline demographic, medical, and surgical data as well as arrhythmia outcomes and procedural complications were evaluated.

RESULTS A total of 8 patients ( 7 pts NIDCM, 1 pt IDCM with mean age:68+-8 years) were enrolled for the treatment of refractory VT with a modified CSD technique. Mean sympathicotomy length were 7.3 (SD 3) min per side. 3/8 patients underwent monolateral (LCSD) sympathicotomy due to strong adesion in the right pleural cavity. Mean follow up was 13 months (SD 6). No complication occurred during the sympathicotomy. An overall reduction in VT burden and VT number was observed after the CSD despite an in-hospital early recurrence in 3 patients.

CONCLUSIONS A modified CSD (sympathicotomy T2–T5) with stellate ganglion sparing and the use of unipolar radiofrequency is feasible, effective, and safe in the setting of untreatable VT. Abstract Figure. VT trend
Prospective evaluation of a hybrid clinical and electrocardiographic algorithm to predict the origin of outflow tract PVCs. A prospective multicenter study
Authors: Carreno Lineros JM , Penela D , Jauregui B , Soto-Iglesias D , Fernandez-Armenta J , Acosta J , Bisbal F , Ordonez A , Chauca A , Scherer C , Berruezo A
Published: May 2021

Funding Acknowledgements

Type of funding sources: Public Institution(s). Main funding source(s): Beca de la Asociación del Ritmo Cardiaco para Formación en Investigación Post-Residencia en centros españoles.

Background

To predict the premature ventricular complex (PVC) site of origin (SOO) before the ablation procedure has important implications. 12 lead ECG information as well clinical characteristics are related with the PVC-SOO, but there is no prospective data validation.

Purpose

This prospective multicenter study sought to analyze the applicability and accuracy of a simple hybrid algorithm that includes electrocardiographic and clinical information in a consecutive patient population with outflow tract (OT) PVCs undergoing catheter ablation.

Methods

Consecutive patients with frequent OT-PVCs and indication for catheter ablation were prospectively included in 4 centers. The vascular access (femoral vein vs femoral artery) and the first outflow tract to be mapped were decided based on a two-steps hybrid algorithm (see Figure 1) including ECG information [R/S PVC precordial transition (PT): early PT if it occurs before V3; late PT if beyond V3) and clinical information [the following variables compute 1 point in a clinical score: age (>59 y.o); presence of hypertension; and gender (man)].

Results

115 consecutive patients [42 (37%) man, 52 + 15 y.o] were included. Mean PVC burden at baseline was 20 ± 13% and mean LVEF was 59 ± 8%. Mean procedure time was 55 ± 26 min. Complete acute abolition of the PVC was achieved in 110 (96%) patients. 84 (73%) patients had the PVC’s SOO in the right ventricle OT (RVOT) whereas 31 (27%) in the left ventricular OT (LVOT). Compared with patients with a RVOT-SOO, those with a LVOT-SOO were more frequently man [18 (58%) vs 24 (29%), p = 0.004], more frequently suffered from hypertension [18 (58%) vs 15 (18%), p < 0.001) and had an early R/S PVC transition [17 (55%) early PT, 3 (10%) late PT) in the case of LVOT-SOO vs 4 (5%) early PT, 55 (65%) late PT in the case of RVOT-SOO, p < 0.001]. The hybrid algorithm accurately anticipated the PVC’s SOO in 101 (88%) patients. A reduction of at least 80% of PVC burden was achieved by 90% of patients at 6 months.

Conclusions

The hybrid algorithm, prospectively evaluated in an international multicenter study, has proved to permit to accurately anticipate the PVC’s SOO (right vs left) in a consultive population of patients with OT PVCs. Abstract Figure 1
Predictors of adequate intraprocedural premature ventricular complex (pvc) frequency during idiopathic pvc ablation
Authors: Demir S , Gulsen K , Kepez A , Uslu A , Kup A , Kanar BG , Kayan F , Yildirim C , Akgun T
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

The aim of the present study was to determine the predictors of adequate intraprocedural premature ventricular complex (PVC) frequency for successful mapping and ablation of idiopathic PVCs.

Methods

A total of 101 consecutive patients (45 men; age: 47.9 ± 14.2 years) who had undergone idiopathic PVC ablation between 01 November 2018 and 24 June 2020 constituted our study population. Clinical and demographic data, procedural details and 24 h rhythm recordings that had been recorded before the procedure were retrospectively evaluated. Total PVC burden and diurnal variability assessed by the ratio of night time (22:00–06:00) over day time (06:00–22:00) PVC burden was calculated. Patients were classified into three groups based on the relationship between hourly PVC number and HR. If there was a significant positive correlation between hourly PVC number and corresponding hourly HR, patients were classified into the fast HR-PVC group. If there was a significant negative correlation between hourly PVC number and corresponding hourly HR, patients were classified into the slow HR-PVC group. Patients were classified into the independent HR-PVC group if there was no significant correlation between hourly PVC number and corresponding hourly HR. Clinical characteristics and Holter parameters were compared between groups with and without adequate intraprocedural frequency of PVCs that permitted activation mapping.

Results

In all, 74 patients had frequent intraprocedural PVC that permitted activation mapping (Group 1) and 27 patients (26.7%) had infrequent intraprocedural PVCs which necessitated isoproterenol infusion or cancellation of ablation procedure (Group 2). PVC burden was significantly higher in the group with frequent intraprocedural PVCs (26.1 ± 9.4% vs 21.2 ± 10.3%; p: 0.026). There were no significant differences between groups regarding the relationship between hourly PVC number and heart rate (Fast HR-PVC 42 (56.8%) vs 18 (66.6%); slow HR-PVC  4(5.4%) vs 3 (11.1%); independent HR PVC 28 (37.8%) vs 6 (22.2%) in the respective order for group 1 and group 2; p: 0.26) or the ratio of night/day PVC burden (median 0.99 (IQR 0.4) vs median 0.83 (IQR 0.54) in the respective for group 1 and group 2 ; p: 0.53). Binary logistic regression analysis revealed the 24 h Holter PVC burden as the sole parameter that is significant predictor of frequent intraprocedural PVCs permitting activation mapping. A Holter PVC burden ≥ 19.43% had 72% sensitivity and 60% specificity for the prediction of sufficient intraprocedural PVCs that permitted activation mapping and ablation (area under the curve: 0.65; p: 0.02)

Conclusion

The 24 h PVC burden was the only predictor of adequate intraprocedural PVC frequency permitting activation mapping during idiopathic PVC ablation.
Noninvasive risk factors for the prediction of inducibility on programmed ventricular stimulation in post-MI patients with ejection fraction over 40% at SCD risk, insights from the PRESERVE EF study
Authors: Trachanas K , Arsenos P , Xenogiannis I , Tsimos K , Triantafyllou K , Vlachos K , Antoniou CK , Dilaveris P , Korantzopoulos P , Kanoupakis E , Tsiachris D , Sideris S , Gatzoulis K , Tousoulis D , Tsioufis K
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

Sudden cardiac arrest (SCA) in post myocardial infarction (post-MI) patients with a relatively preserved left ventricular systolic function (LVEF≥40%) has an annual incidence of 1%, in the absence of adequate risk stratification methods and guideline recommendations for primary prevention. In the PRESERVE-EF study we used a two-step SCA risk stratification approach to detect patients at risk for major arrhythmic events. Seven noninvasive risk factors (NIRFs) were extracted from ambulatory electrocardiography (AECG). Patients with at least one NIRF present were referred for invasive programmed ventricular stimulation (PVS). Inducible patients received an ICD.

Purpose

To assess the performance of NIRFs extracted from 24hr AECG, based on the PRESERVE EF criteria, in predicting inducibility.

Methods

The PRESERVE EF study enrolled 575 patients. Two hundred and four of them had at least one NIRF and an indication for PVS, but 52 of them declined. Finally, 41 out of 152 patients who underwent PVS were inducible. For the present analysis data from these 152 patients (mean age 60 ± 10years, LVEF 49 ± 6%, 89% males) were analyzed. Chi-square test, univariate logistic regression and areas under ROC curves were calculated for the PVS inducibility endpoint.

Results

Age, male gender and LVEF for the PVS inducible patients group (n = 41) and the noninducible patients group (n = 111) were, respectively: 61 ± 9years vs 59 ± 10years (p = 0.310), 98% vs 86% (p = 0.048), 45 ± 4% vs 51 ± 7% (p < 0.001). Among NIRFs examined, LVEF ≤ 50%, nsVT≥1/24hour and presence of LPs on SAECG presented high and significant Odds Ratios (ORs) for a positive PVS study end point. A simple risk score based on cutoff points of LVEF ≤ 50%, NSVTepisode≥1/24hour and presence of LPs missed only 1 out of the 41 inducible patients and yielded: OR 14.146 (p = 0.01) with a high sensitivity 98% but low specificity 26% for a positive PVS (AUC = 0.65).

Conclusion

Cut off points of LVEF ≤ 50%, nsVTepisode≥1/24hour and presence of LPs were important predictors of inducibility. A simple risk score based on these predictors achieves high sensitivity but low specificity.  The final decision for an ICD implantation should be based on a positive PVS, which is irreplaceable in risk stratification.
Left bundle branch pacing: efficacy and safety compared to right ventricular outflow tract pacing
Authors: Riano Ondiviela A , Cabrera Ramos M , Ruiz Arroyo JR , Ramos Maqueda J
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Introduction

Patients with preserved left ventricular ejection fraction (LVEF) and atrioventricular block (AVB) who are anticipated for high-burden of right ventricular (RV) pacing possess a risk to develop pacing-induced cardiomyopathy and adverse clinical outcomes. Left bundle branch pacing (LBBP) has recently emerged as a mode of conduction system pacing in the quest for physiological pacing.

Purpose

The aim of our study was to assess LBBP feasibility and safety compared to right ventricular outflow tract pacing (RVOTP).

Methods

Single centre randomized clinical trial to investigate acute success, feasibility and safety of LBBP versus RVOTP. May to October 2020. Patients with pacemaker indication and preserved LVEF were randomized 1:1 and followed up 3 months. Success was defined in LBBP group as a paced ECG < 120ms or with a 20% length reduction from the basal ECG.

Results

120 patients were randomized, 60 in each group, 61% males. The mean age was 77,9 ± 9 years and third-degree AVB was the main pacing indication. The procedure was successful in 95% of the cases in both groups (p = 1). The paced QRS interval was narrower in the LBBP group compared to the RVOT group (99 ± 2 ms vs 113,6 ± 11,7 ms, p < 0,001). Lower fluoroscopy times were achieved in LBBP group (3.1 ± 2.1 min vs 4.3 ± 3.4, p = 0,035) and also longer procedure times in LBBP group (68,9 ± 36,9 min vs 44,3 ± 18,7 min, p < 0,001). No complications were achieved and no difference in ventricular lead dislocation was found between both groups (1.6% vs 1.6%)(p = 1).

Conclusions

LBBP is feasible, safe and provides a narrower paced QRS compared to RVOTP. LBBP required lower fluoroscopy times but longer procedure times compared to RVOTP. LBBP (n = 60) RVOTP (n = 60) p Age (mean ± SD) 76,7 ± 9 79,7 ± 8 0,067 Male gender 62 (37) 60 (36) 1 Successful procedure 95 (57) 95 (57) 1 Basal left bundle branch block 15 (9) 13 (8) Basal QRS duration (mean ± SD) 112,6 ± 29,6 109,9 ± 25,8 0,59 Pacing QRS duration (min)(mean ± SD) 99 ± 2 139,6 ± 11,7 < 0,001 Procedure time (min) (mean ± SD) 68,9 ± 36,9 44,3 ± 18,7 < 0,001 Fuoroscopy time (min)(mean ± SD) 3.1 ± 2.1 4.3 ± 3.4 0,035 R wave (mV)(mean ± SD) 9,9 ± 5,7 9,9 ± 5 0,98 Right ventricle pacing threshold (V)(mean ± SD) 0,67 ± 0,3 0,58 ± 0,24 0,08 Ventricular lead dislocation 1.6 (1) 1.6 (1) 1
Long-term follow-up of heart transplant patients treated with permanent pacemaker: a monocentric study
Authors: Tua L , Turco A , Acquaro M , Scelsi L , Greco A , Ghio S , Savastano S , Sanzo A , Vicentini A , Petracci B , Vullo E , Vicini Scajola L , Pelenghi S , Oltrona Visconti L , Rordorf R
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background and purpose

Permanent pacemaker implantation (PPMi) is needed in about 5% of patients following heart transplant (HTx) primarily due to sinus node dysfunction (SND), which commonly occurs in an early phase, or to atrio-ventricular block (ABV), which is common later on. Currently, data on rate of ventricular pacing (VP) is lacking and little is known on long-term outcomes after PPMi.

Methods

This was a retrospective, monocentric study. Among 1123 patients treated with HTx, all with biatrial technique, from november 1985 to march 2019 at our institution, 61 (5.4%) patients needed PPMi. PM parameters, clinical and echocardiographic data were collected at 1 month and at 1-3-5-10 years follow-up. The primary aim was to analyse the percentage of right ventricular pacing in the overall population and in subgroups stratified by the timing of PPMi and by pacing indication. Secondary endpoints were to analyze long-term outcomes according to the percentage of ventricular pacing and to the type of implanted PM (single vs. dual chamber). 

Results

Among patients treated with PPMi (68.9% single-chamber), 62.2% were implanted for SND and 36% for AVB. Early PPMi (< 3 months after HTx), occurred in 34.4% of patients, mainly due to SND, while late PPMi (> 3 months after HTx) occurred in 65,6% with an equal distribution between SND and AVB. Median follow-up time from HTx was 140 months and 82 months from PPMi. Overall mean rate of VP was 21%. Rate of VP was higher in patients implanted early rather than late after HTx, both at 1 month (91% vs 2%, P = 0,002) and at 1 year after the procedure (43 vs 1, P = 0,037). Patients with AVB had a greater rate of VP compared to those implanted for SND, irrespective of timing of implantation and these findings were still present at 3 and 5 years follow-up (62 vs 1%, P = 0,011 at 3 years and 80 vs 6%, P = 0,002 at 5 years). VP declined progressively after PPM implantation. No differences were observed in terms of 10-years mortality between early vs late PPMi, dual vs single-chamber and mean VP > 21% vs ≤ 21%.

Conclusions

Patients treated with PPMi after HTx show on average low percentage of VP over long-term follow-up. AV block indication and early implantation are associated with a higher percentage of VP. The rate of VP, the timing of PPMi and the use of single vs dual chamber PM do not affect overall prognosis or left ventricular systolic function. Our data may justify implantation of a single-chamber PPM, which bears less complications and procedural time, in the majority of HTx patients needing PPMi.
How many patients treated for bradycardia may be eligible for His bundle pacing?
Authors: Chattopadhyay R , Chousou P , Thomas R , O"brien J , Pierres F , Hayes J , Vassiliou V , Pugh PJ
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Introduction

Pacing-Induced Cardiomyopathy (PICM) can lead to significant morbidity, requiring treatment by device upgrade procedures. The risk of occurrence is directly related to the burden of right ventricular pacing, which can be reduced by careful device programming. When frequent ventricular stimulation cannot be avoided, pacing the conduction system may offer an alternative to myocardial pacing and reduce the risk of PICM. The most recent international pacing guidelines recommend that His-bundle pacing should be considered among 1) patients with EF 36-50% and expected to require >40% ventricular pacing (Vp > 40%) (class IIa); and 2) patients requiring pacing who have block at the level of the AV node (class IIb).

Purpose

This study sought to determine how many patients undergoing bradycardia pacing would have fulfilled those criteria.

Methods

This was a single-centre retrospective study over a 5 year period to the end of April 2020. Demographic and clinical details of patients receiving device implants were obtained from the Pacing Service Database, along with the indication for pacing, electrocardiographic and echocardiographic data. A cardiology consultant with a special interest in pacing reviewed each case with regards to the likelihood of requiring >40% ventricular pacing. Heart block at the level of the AV node was considered present if patients presented with a narrow QRS in conjunction with second or third degree heart block.

Results

1,265 patients underwent pacemaker implant for bradycardia during the study period, 888 for conduction system disease (198 second degree block, 333 complete heart block), 349 for sinus node disease and 28 for other indication. Figure 1 gives a breakdown of patients with conduction system block according to i) level of block; ii) ejection fraction; iii) expectation or not of Vp > 40%.  In total, 166 patients had a class IIa indication for His-bundle pacing. 227 patients had block at the level of the AV node, of whom 36 also fulfilled the class IIa criteria for His-bundle pacing; 191 patients (16% of the total) had a sole class IIb indication for His-bundle pacing. Adjusting for the 176 patients who did not undergo echocardiography, up to an additional 45 patients may be expected to have an indication for His-bundle pacing

Conclusion

As many as 32% of patients in a bradycardia pacing population may be eligible for His-bundle pacing. This has significant implications for training and service provision. Abstract Figure 1. Flowsheet showing distribution
Success and failure for implantation of left bundle branch pacing using stylet-driven pacing leads : a single center experience
Authors: So T
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background/Introduction :Left bundle area pacing is a new modality of physiological pacing. By screwing the pacing lead deep into the interventricular septum, the left bundle branch could be recruited for pacing purpose. Initially left bundle area pacing was performed with fixed helix lead supported by the delivery catheter. On the other hand, there are studies showing the feasibility of using a style-driven extendable helix with the new delivery sheath for left bundle area pacing. 

Purpose :To study the feasibility of left bundle area pacing and explore factors associated with success and failure

Methods :This is a retrospective study from September 2020 to January 2021 in a local hospital. Baseline patient characters, procedural characters, acute complication and reason for failure were recorded. Logistic regression was done to explore factors associated with success and failure. 

Results :In 14 patients, the mean age is 81 +/- 6.8 years with 28% female. Pacing indications were sick sinus syndrome (n = 3) and atrio-ventricular block (n = 11). The success rate is 64% (n = 9/14). The average R wave sensing was 11.4 +/- 4.5mV, the average V pacing threshold was 0.88 +/- 0.23V @ 0.4ms and average impedance was 633 +/- 93.6 Ohm. There were no septal perforation nor pericardial effusion after implantation. The most common reason for failure is lead dislodgement during implantation (n = 4) and the other reason is failure to locate and capture the left bundle (n = 1). In logistic regression, there was no clinical risk factor identified to predict failure for implantation , i.e. diabetics ( OR 0.95, p =0.15), hyperlipidaemia (OR 0.87, p =0.94), chronic renal disease (OR 0.88, p = 0.94), coronary heart disease (OR 0.37, p = 0.66). Gender(OR 4.5, p = 0.37), age(OR 1.1, p = 0.32) and hypertension(OR 25, p = 0.25) may appear to predict failure for implantation but the results were not statistically significant. 

Conclusion :Left bundle area pacing could be feasible and safely implanted using style-driven lead with good pacing parameters. No clinical factor is identified to predict the failure of implantation, the main reason for failure is dislodgement of lead during implantation. Similar finding was noted in a study comparing lumen-less lead and stylet-driven lead.2 In this study found that reason for failure of left bundle area pacing using style-driven lead was due to repetitive lead dislodgement after slitting the delivery sheath, fail advancement of lead into septum and loose septal endocardium. Stability and ability to screw into septum remain a great obstacle for left bundle area pacing using stylet-driven lead. This study is limited by small sampling size and single center retrospective study. Further studies are needed to see the long term outcome of left bundle area pacing using style-driven lead and investigate other methods to predict success/ failure of implantation, such as the role of imaging.
Long term stability of the subcutaneous cardioverter defibrillator implanted by means of the intermuscular two incision technique
Authors: Bisignani G , Bisignani A , Cavaliere AL , Lovecchio M , Valsecchi S , De Bonis S
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background To ensure effective defibrillation with the subcutaneous implantable cardioverter defibrillator (S-ICD), both the lead and the generator must be adequately positioned extrathoracically. We assessed the long-term adequacy of the S-ICD system position and its stability in a group of patients who received the S-ICD by means of the two-incision intermuscular technique.

Methods The PRAETORIAN score uses chest radiography to provide feedback on S-ICD positioning, and identifies patients with high defibrillation thresholds. We compared radiographs taken immediately after implantation and on 12-month follow-up examination.

Results We analyzed data from 38 patients with the S-ICD generator positioned in an intermuscular pocket. The median PRAETORIAN score was 38 [25th to 75th percentile: 30 to 60]. Two (5%) patients had a score of 90 (intermediate risk of conversion failure). The thickness of the adipose tissue between the coil and the sternum was ≤1 coil width in 72% of patients, the generator was on, or posterior to, the midline in 94% of patients, and the amount of fat tissue between the generator and the thoracic wall was less than the generator width in 78% of patients. No generator or electrode dislodgments were detected on analyzing radiographs collected at the 12-month visit. In all patients, assessment of the PRAETORIAN score confirmed the values calculated on post-implantation analysis. During follow-up, no ineffective therapies, sudden cardiac or device-related deaths occurred.

Conclusions The position of the S-ICD system implanted using the two-incision intermuscular technique was adequate at the time of implantation and remained stable after 12 months.
Gradually increasing impedance in patients with pacemakers and implantable defibrillators: a watchful waiting strategy
Authors: Maass A , Klingenberg M , Groenveld HF , Mulder BA , Blaauw Y , Rienstra M
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Introduction

Pacing impedance measurements are important in the surveillance of pacemaker and implantable cardioverter/defibrillator (ICD) devices. Whereas sudden changes in impedances can reflect lead fracture or isolation defects, gradually increasing impedances are thought to occur because of calcifications at the endomyocardial interface. In many cases, these leads are replaced prophylactically but this has not been studied systematically.

Purpose

We aimed to identify the outcome of right ventricular (RV) electrodes with high impedances that were left active in this single center study.

Methods

All patients in the electronic patient database were screened for impedances >1200Ohms. 41,201 individual recordings led to 207 individual patients. 161 patients were excluded from the analysis due to sudden impedance increase, temporarily high impedances or wrong entry. Of the remaining 46 patients, baseline characteristics as well as pacing impedance, sensing values, pacing thresholds, and shock impedance in case of ICDs were recorded.

Results

There were 17 pacemaker and 29 ICD patients, 68 ± 15 years old, 70% were male. Glomerular filtration rate at baseline was 81 ± 22 ml/min/1.73m2. Baseline RV impedance was 597 ± 123Ohms. During follow-up impedances increased to 1875 ± 682Ohms (p < 0,001). Pacing thresholds increased from 0,6 ± 0,4V to 3,0 ± 1,9V (p < 0,001). Sensing remained stable. The median time from implant to  impedance rise >1000Ohms was 5,5 (3,4-7)years and median follow-up thereafter 2,4 years (1,2-4,2). During follow-up, no intervention was performed for 33 leads (72%). No events occurred. 13 leads (28%) were replaced , 9 prophylactically (mostly because of ICD advisory leads), 3 because of high pacing thresholds and high percentage pacing and one lead because of noise oversensing, probably unrelated as it occurred 7 years after impedance increase.

Conclusions

A watchful waiting strategy appears to be a safe option for patients with ICDs and pacemakers with low percentage pacing. As impedance increase cannot be used for surveillance for imminent lead fracture, other means such as short interval counts and non-sustained oversensing have to be employed and should be combined with remote monitoring.
Prevention of sudden cardiac death by the implantable cardioverter-defibrillator in adults with inherited heart disease. long term follow-up
Authors: Herruzo Rojas M , Gomez Lopez A , Martin Toro MA , Gonzalez Perez PJ , Morales Ponce FJ
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

BACKGROUND

Inherited heart diseases include all inheritable channelopathies or cardiomyopathies. Sudden cardiac death (SCD) might be the first and last clinical presentation. ICD implantation  is established as a therapeutic tool according to risk criteria.

OBJETIVES

The aim of this study is to analyze the population characteristics in ICD/ CRT-ICD recipients in patients with inherited heart disease and establish possible risk predictor factors of arrhytmogenic events during follow-up.

MÉTHODS: This is a prospective single-center registry. We included all patients from January1, 2012, to December 31, 2020 who subsequently underwent ICD/ ICD-CRT implantation.

RESULTS

A total of 172 patients were included with a mean age of 60.47 ± 13,1 years and a mean follow-up duration of 49.71 ± 41.8 months. The most frequent underlying cardiac condition was dilated cardiomyopathy (58.1%), followed by hypertrophic cardiomyopathy (15.7%), arrythmogenic cardiomyopathy (2.3%), long QT syndrome (1.7%), Brugada syndrome (1.2%), catecholaminergic (2.9%) , idiopathic (7%) and others (11%). 89 ICDs (51.7%) and 83 ICD-CRTs (48.2%) were implanted for primary prevention of SCD.

During follow-up, 13.4% of the patients experienced arrhythmogenic events. Only 4.1% of the patients experienced inappropriate shock, secondary to supraventricular arrhythmias all of them. Genetic testing was done in only 14.1% of our patients.

In the 27 cases of hypertrophic cardiomyopathy, 25 (92.6%) underwent ICD implantation for primary prevention. 14 patients (51.9%) had family history of SCD, 8 (29.6%) had unexplained syncope and 16 (59.3%) had ventricular tachycardia in the Holter monitoring. The mean left atrial size was 44.15 ± 7.2mm, mean maximum LV-wall thickness 22.85 ± 5,25mm, and a mean LVOT gradient of 30.56 ± 31.3mmHg, with a mean actual HCM SCD-score of SCD over 5 years of 5.84 ± 3.53%. According to traditional parameters, 100% of the HCM sample meet criteria for ICD implantation in primary prevention compared to 66.7% according to the new score.

During follow-up 2 patients (7.4% ) experienced arrhythmogenic events, and 3 patients (11.1%) had inappropriate shocks secondary to supraventricular arrhythmias.

Genetic testing was done in 22.2% of the patients and was positive for a known pathogenic mutation in half of the cases.

None of the parameters evaluated in the current score, a high risk of SCD according to it, having old high risk criteria or implanted of ICD in secondary prevention were related in our study with more arrhytmogenic events.

CONCLUSIONS

ICD implatation for primary prevention is the main indication in our population. Either classic factors or the new HCM SCD-score were no related in our study with the presence of arrhytmogenic events during follow-up.
Slow VT treatment in a contemporary population of primary prevention ICD recipients
Authors: Angeletti A , Ziacchi M , Martignani C , Massaro M , Statuto G , Sorrentino S , Piemontese GP , Capobianco C , Spadotto A , Minguzzi A , Diemberger I , Biffi M
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

Implantable cardioverter defibrillator (ICD) is an effective therapy for sudden cardiac death (SCD). 2015 HRS/EHRA/APHRS/SOLAECE expert consensus document suggests long VT detection, above 185 bpm, as optimal ICD programming to reduce unnecessary therapies in primary prevention (PP).

Purpose

The aim of our study is to evaluate incidence, safety and efficacy of ICD treatment for VT arrhythmias below 185 bpm, in a contemporary population of PP ICD recipients with long detection intervals (LDI), morphological discrimination algorithm and antitachycardia pacing therapies (ATP) before shock.

Methods

We conducted a single centre retrospective study enrolling 236 patients implanted with a primary-prevention indication from January 2013 to June 2019. Patients were implanted with single or dual chamber single-lead transvenous ICD. All patients had standard device setting with long (at least 20 s in VT and 7 s in VF) VT/VF detection above 150 bpm and therapies starting from 171 with up to 5 ATP and multiple shocks. PainFREE-like bursts and Schaumann-like ramps ATP were always set in VT zone. Of each patient we collected a detailed report of up to five appropriate events and three inappropriate events. Arrhythmia diagnosis was confirmed from 3 independent expert physicians.  Date of the event, cycle length, type of morphology (polymorphic or monomorphic), therapies with their effect were collected.

Results

During a mean follow-up of 42 months, 47 (20 %) and 18 (8%) patients had at least one appropriate and inappropriate activation, respectively. The detailed-events analysis shows that 16 (7%) patients had 38 (30%) appropriate events with rate <188 bpm. At these rate ATP were 97% effective. 14 (38%) of inappropriate activations were caused by arrythmias with ventricular rate below 188 bpm and half of these received a shock; 30% of inappropriate shocks were due to arrhythmia with rate <188 bpm. 73% of treated events, with rate <188 bpm, were appropriate. Only 5.6% (n = 10) of ATP attempts cause arrhythmia acceleration.

Conclusions

One third of detected arrhythmias had a rate below 188 bpm and 73% were true VT. In this slow VT zone, ATP had a high success rate with low percentage of acceleration.
Prognostic impact of subcutaneous implantable cardioverter-defibrillator appropriate and inappropriate shocks
Authors: Oliveira L , Cavaco D , Rodrigues G , Matos D , Carvalho MS , Carmo J , Santos PG , Costa F , Carmo P , Santos I , Morgado F , Mendes M , Adragao P
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

Previous studies have shown an adverse prognosis for patients with transvenous implantable cardioverter-defibrillators (ICD) who receive both appropriate and inappropriate shocks. There is a paucity of data regarding the prognosis of inappropriate shocks in patients with a subcutaneous ICD (S-ICD).

Purpose

To assess and characterize S-ICD appropriate (AS) and inappropriate shocks (IAS) and their impact on mortality.

Methods

Single center observational registry of 162 consecutive patients who underwent S-ICD implantation for primary and secondary prevention between November 2009 and September 2020. Only follow-up data of at least 6 months was analysed to identify predictors of both IAS and AS and their mortality impact.

Results

A total of 144 patients were included in the analysis. Mean age was 42.2 ± 16.6 years and 75% of the patients were male. One hundred and four patients (72.2%) implanted the S-ICD in primary prevention. The most common etiology was ischemic cardiomyopathy (22.9%) followed by hypertrophic cardiomyopathy (18.8%) and dilated idiopathic cardiomyopathy (14.6%). During a mean follow-up of 42.3 ± 29.9 months a total of 48 patients (33.3%) experienced at least one S-ICD shock. Twenty-nine (20.1%) patients received AS due to VT/VF and 31 patients (21.5%) received IAS. Eighteen (58.1%) of the IAS were due to oversensing/noise/discrimination errors and the remaining due to supraventricular tachycardia. Overall, patients with AS (HR 4.93, 95% CI 1.58-15.36, p = 0.006) and higher number of total AS (HR 1.10, 95% CI 1.00-1.20, p = 0.044) were associated with higher mortality during follow-up. S-ICD IAS therapy did not affect overall mortality (HR 1.71, 95% CI 0.21-14.0, p = 0.616). Conclusions: In patients with S-ICD, those who receive AS, in contrast to IAS, seem to have a worse prognosis. Large scale studies are needed to confirm this hypothesis and to explain this findings. Abstract Figure. Survival curves for AS and IAS
Defibrillation success after subcutaneous implantable cardioverter-defibrillator generator replacement is not affected by impedance increase
Authors: Van Der Stuijt W , Pepplinkhuizen S , Quast ABE , Smeding L , Olde Nordkamp LRA , Wilde AAM , Knops RE
Published: May 2021

Funding Acknowledgements

Type of funding sources: None.

Background

Routine defibrillation testing during implant and replacement of the subcutaneous implantable cardioverter-defibrillator (S-ICD) is recommended per current guidelines. Recently, concerns have been raised about an increase in shock impedance and consequent shock failure during defibrillation testing in S-ICD patients undergoing a generator replacement.

Purpose

We aim to describe the defibrillation success rate in relation to the shock impedance in patients undergoing S-ICD generator replacement in our large tertiary center.

Methods

In this retrospective analysis, data from replacement procedures were collected from all patients who underwent an S-ICD generator replacement in our center from June 2014 to December 2020. Defibrillation testing was performed with at least one shock of ≤65J, and a successful shock was defined as terminating the ventricular arrhythmia within 5 seconds after the shock.

Results

A total of 133 patients underwent an S-ICD generator replacement, 5.8 ± 0.9 years after initial implant. Reasons for replacement were: reaching of elective replacement indicator (n = 119), early battery depletion (n = 9), complaints of generator pocket (n = 3) and device malfunction (n = 2). Defibrillation testing was performed in 111 patients (86.5%) undergoing a replacement procedure. Shock impedance data from both the implant and replacement procedure were available in 101 patients. The median shock impedance of these patients during their replacement procedure was significantly higher than during their implant, 79Ω (IQR 66-94) and 66Ω (IQR 57.5-81) respectively (Z = -5.552, p < 0.001). Despite the higher shock impedance, first shock during defibrillation testing was successful in 105/111 patients (94.6%), with a success rate of 97.3% after two attempts. In the remaining three patients, the ventricular arrhythmia could only be terminated with a 80J shock. This was the case during both their initial implant and their replacement procedure. Shock impedance increase between implant and replacement was not significantly higher in patients with a successful first shock compared to patients with an unsuccessful first shock (Δ+11.1 ± 20.0Ω versus Δ+12.7 ± 27.6Ω, p = 0.86).

Conclusion

In this large retrospective analysis, we have shown a first shock success rate during S-ICD generator replacement of 94.6%, which is similar to the success rate of defibrillation testing after initial implant. After multiple attempts, defibrillation testing success rate was 100%. Even though the median shock impedance during replacement was significantly higher than during the initial implant, there was no difference in impedance increase in patients with a successful shock compared to patients with an unsuccessful shock. Abstract Figure. Defibrillation success