bluuebunny/crossref_metadata_2025 huggingface dataset:
The prognostic value of HLA loss of heterozygosity after allogeneic hematopoietic stem cell transplantation in children with relapsed acute leukemia
Authors: Tsvetkova L. A. , Evdokimov A. V. , Barkhatov I. M. , Paina O. V. , Epifanovskaya O. S. , Babenko E. V. , Ivanova N. E. , Rakhmanova Zh. Z. , Kozhokar P. V. , Frolova A. S. , Osipova A. A. , Ryabenko S. V. , Kozlov D. V. , Gindina T. L. , Semenova E. V. , Kulagin A. D. , Zubarovskaya L. S.
Published: May 2023

The loss of a patient-specific HLA haplotype on the surface of the blast cell population is one of the ways a tumor can evade the immune surveillance of donor cells. This phenomenon is observed in approximately 30 % of relapses in patients with hematologic malignancies who underwent partially mismatched allogeneic hematopoietic stem cell transplantation (HSCT). In this study, for the first time, a large cohort of pediatric patients (n = 80) with relapsed acute myeloid (AML) or acute lymphoblastic (ALL) leukemia after allogeneic HSCT was analyzed with the help of the STR method (highlypolymorphic microsatellite marker analysis) using 6 HLA haplotype markers. The study was approved by the Independent Ethics Committee and the Scientific Council of the I. P. Pavlov First Saint Petersburg State Medical University of Ministry of Healthcare of the Russian Federation. Loss of heterozygosity (LOH) was observed in 18 / 80 (22 %) relapsed patients with various types of acute leukemia: out of these, 8 / 44 (18 %) patients had B-cell ALL, 4 / 10 (40 %) patients – T-cell ALL and 6 / 25 (24 %) patients – AML. All relapses with LOH were observed in patients who had undergone haploidentical HSCT, and were found to occur later than relapses without loss of the HLA haplotype (median time to relapse: 8.8 months vs 6.2 months, p = 0.043). In the patients treated with haploidentical HSCT (n = 61), we assessed factors increasing the risk of LOH at relapse. The number of previous therapy lines in the patients with AML (n = 17) and acute or chronic graft-versus-host disease in the patients with ALL (n = 44) were associated with an increasedrisk of genetic loss of the HLA haplotype (p = 0.008 and p = 0.015 respectively). A relapse following the second allogeneic HSCT was associated with LOH in 4 / 5 (80 %) patients, p = 0.008. The prognosis of the patients with LOH was extremely poor. At a median follow-up of 6 months, the overall survival from relapse was 22 % in the LOH group and 37 % in the non-LOH group. The median overall survival was 4.5 months (95 % confidence interval 3–NA) and 10.3 months (95 % confidence interval 5.7–16.1) respectively, p = 0.063. Among the patients with LOH, the best survival rates were observed in those who had undergone a repeat allogeneic HSCT from a different donor. Thus, the analysis of LOH is an important tool for determining the prognosis and further treatment in pediatric patients with acute leukemias. We strongly recommend that this diagnostic test should be included into standard testing of patients after partially-mismatched allogeneic HSCT.
Criticus non fit, sed nascitur:
Authors: Redondo Reyes Pedro
Published: May 2023

Desde los inicios de la gramática como disciplina sistemática en la antigua Grecia se ha planteado la cuestión del tratamiento de los fenómenos singulares en el marco de los paradigmas regulares. Aunque triunfó la idea de que la gramática (y, por tanto, la filología) es una tekhne, se sostuvo asimismo que se trataba de una empeiria, uno de cuyos elementos metodológicos era la observación de lo particular. Este concepto vuelve a surgir en el siglo XIX en el tratamiento del problema de la circularidad tanto en la crítica textual como en la hermenéutica, aunándose con el del carácter del intérprete. Se estudian los acercamientos a la idea de observación filológica en Ptolomeo Peripatético, Schleiermacher, Nietzsche y Giorgio Colli.
Pedro Olalla (2022): Palabras del Egeo: El mar, la lengua griega y los albores de la civilización
Authors: Macías Villalobos Cristóbal
Published: May 2023

Reseña del libro Palabras del Egeo: : El mar, la lengua griega y los albores de la civilización de Pedro Olalla
Santiago Carbonell Martínez (2021): Cuando las ovejas griegas balan: Historia de la pronunciación erasmiana en Grecia y la tradición escolar hispana
Authors: Pozuelo Lobillo Alba
Published: May 2023

Reseña de Cuando las ovejas griegas balan: Historia de la pronunciación erasmiana en Grecia y la tradición escolar hispana de Santiago Carbonell Martínez.
Suzanne Varga (2021): Le retour des mythes antiques dans la poésie lyrique du Siècle d’Or
Authors: Zuili Marc
Published: May 2023

Reseña de Le retour des mythes antiques dans la poésie lyrique du Siècle d’Or de Suzanne Varga.
Luis Unceta Gómez y Helena González Vaquerizo (eds.) (2022): En los márgenes del mito. Hibridaciones de la mitología clásica en la cultura de masas contemporánea
Authors: López Trujillo Víctor Manuel
Published: May 2023

Reseña de En los márgenes del mito. Hibridaciones de la mitología clásica en la cultura de masas contemporánea de Luis Unceta Gómez y Helena González Vaquerizo (eds.).
Rafael Malpartida Tirado (2021): Una nueva mirada entre la literatura y el cine: el legado de Juan Luis Alborg
Authors: Vargas Estrada Juan Jesús
Published: May 2023

Reseña de Una nueva mirada entre la literatura y el cine: el legado de Juan Luis Alborg de Rafael Malpartida Tirado.
Pino Menzio (2021): Mar abierto (1980-2020)
Authors: Muñoz Rivas José
Published: May 2023

Reseña de Pino Menzio (2021): Mar abierto (1980-2020).
Manuel Pacheco Sánchez (2022): Los ritmos del lenguaje
Authors: Rubio Ortega Andrea
Published: May 2023

Reseña de Los ritmos del lenguaje de Manuel Pacheco Sánchez.
Would Isolationist Presidents Cause War?
Authors: Küntay Ismail Burak
Published: May 2023

In American politics, it has been seen that the presidents, who came to power from an isolationist perspective, contrary to their rhetoric, find themselves in the greatest wars in American History. In this study, it was researched whether the isolationist rhetoric of some Presidents who were sitting in the presidency during the period of the great chaos experienced in the USA and the world resulted in great wars, or whether the discourses that winning the elections to these Presidents should have an isolationist approach as a result of decomposition of the world and reflection of economic problems to their countries. The assumption of this study is that the Presidents who won the elections with their isolationist rhetoric were later faced with major wars during their presidency as a result of the processes that had laid their foundations before they were President and their infrastructure had been formed in the light of developments in the world. In this context, the internal political and international conjuncture of William McKinley, Woodrow Wilson and Franklin D. Roosevelt periods will be evaluated. Accordingly, domestic and foreign policy statements and decisions of the presidents will be analyzed. As a result of the analysis carried out in the conclusion section, there will be an inference and foresight on American internal policy and foreign policy regarding the isolationist discourse in the Donald Trump period that is on the agenda.
Thai Youth’s Leadership Code: Characteristics of Leadership from the Perspective of Thai Youth
Authors: Sombongse Chutimon , Tungkasmit Smith
Published: May 2023

The purpose of this study were: 1) to define the characteristics of leadership from the perspective of Thai Youth and 2) to investigate the Thai Youth Leadership Code by using Leadership Code Model. This study is qualitative research using Descriptive Methodology. The informants of the study are 16 Thai youth leaders (15 – 24 years old) who had participated in any oversea high school exchange student program to represent group identity. The data was collected by in-depth interview using key questions to define physical traits, style, situation, competencies, results, and brand of leadership. Data was analyzed following the Leadership Code Model which have 5 rules of leadership and 2 dimensions of time and attention. The findings indicated that Leadership from youth’s perspectives can be classified as Personal Proficiency, Executor and Strategist respectively. The context of time has been found in Near-term operational dimension and the context of attention has been found in Organization dimension. Youth’s Leadership prioritizes developing themselves first while the meaning of the organization is their society. In conclusion, this study found that the Leadership Code Model is the decent baseline for organizational leadership study rather than society, and is incomplete for youth’s leadership evaluation. The recommendation is to conceptualize Youth’s Leadership Code Model that is appropriate for youth’s leadership study.
BATASAN HAK SUAMI DALAM MEMPERLAKUKAN ISTRI SAAT NUSYUZ
Authors: Harahap Risalan Basri
Published: May 2023

Nusyuz is a conception of classical law of the past, what we inherit not only as part of the Islamic thought tradition has even been codified as a standard rule of law. This is reflected in the existence of several rights of the husband in cracking down on the wife who is oblivious without clear boundaries. Whereas for the wife almost has no room to defend themselves and their rights before the law in a balanced manner. Therefore, in this study as well as legal research in general, the approach used is doctrinal research in order to find the principle or doctrine of positive law that applies in relation to the problem under study, in the form of opinions and ideas from legal experts regarding boundaries. the limitation of the husband's right to treat his wife who is infamous. Then describe it in general, classify it and analyze it critically using inductive reasoning. This is because in every discussion of the issue of nusyuznya the wife often forgets the basic principle or principle as a parameter in granting restrictions on the rights and authority of the husband over the wife. Like the principle of the pattern of relations between husband and wife in Islam, the purpose of sanctions and also in seeing the legal substance of the actions of Nusyuz itself, both in terms of quality, quantity and things that trigger the problem. Nusyuz's legal issues often have a negative impact on the position of women, and can even be one of the triggers of violence against them.
KONSEP HAK MILIK DALAM ISLAM
Authors: Sainul Ahmad
Published: May 2023

The definition of property rights is the same, namely that property or ownership is a relationship of ownership between humans and assets or objects applied by syara ', which provides powers that allow us to take advantage of or carry out tasarruf over these assets or objects in ways that are justifiably stipulated. By syara '. The system of ownership has been described much by jurisdictorials as that property rights are divided both it is perfect and impective.In addition to ownership types of individual, public ownership, and state ownership with various conditions in it. Present The causes and ways of Obtaining ownership between other because of work, inheritance, Giving state assets to the people, Assets acquired without compensation for assets or personnel, and individual gain.Wisdom and Property Rights between other: Humans may not own property carelessly, without knowing the applicable rules that have been revealed by Islam. Humans will have the principle that looking for wealth must be in ways that are good, correct and lawful. Owning property is not an absolute right for humans, but is a mandate (entrusted) from Allah SWT. What must be used and utilized as much as possible for the benefit of human life and channeled in the way of Allah to obtain His approval. Last of islam banks Taking Other People Ownership in Wrong Ways
KELUARGA SAKINAH PERSPEKTIF MAHASISWA YANG SUDAH MENIKAH
Authors: . Hasiah
Published: May 2023

We find that in almost all public and private universitiesin Indonesia, several married students are found. Students who decide to get married eill be facedwith conditions where they should be contrindicated to complete academics, graduate early, then get a job, must be able to manage time, shareenergy and take care of the family. Students wh get married while in college, of course have strong reasons, have the motivation and drive to get married durring their studies.In this study, researchers used a qualitative descriptive methode with data collection techniques through observation, interviews or direct interviews with informants. Sampling conducted by researchers with purposive sampling. And the focus of this research is the Padangsidimpuan State Islamic Institutestudents who are registered as active and marriedstudents.The results of the study informed that the motivation of students who got marriedat the timeof study was fear of sin, the existence of compatibility and mutual need, feeling that they had been obliged to marry (old enough), there was guidance from others.
DALIHAN NATOLU DAN TRADISI MARGONDANG DALAM PERKAWINAN DI BATAK ANGKOLA
Authors: Rohana Nada Putri
Published: May 2023

Marriage is a crucial thing in the marriage section, this is often considered urgent for every family. Marriage underlies two sides in its implementation, namely between religion and custom. Angkola Batak is one of the regions in Indonesia that has specialties in terms of tradition or culture in carrying out marriages that involve the social system of society and culture. The results of the study indicate that the social system of society that begins with the marriage bond gives rise to a dynamic position or position in the family sphere. This also makes this social system intact and strong to maintain the integrity of a marriage. In addition, the cultural values that exist in the tradition also have a good influence on maintaining the diversity that can be taken from the values that exist in its implementation.
ANALISIS HUKUM ISLAM DAN HUKUM POSITIF TERHADAP FENOMENA MONEY POLITIC
Authors: Siregar Syapar Alim
Published: May 2023

In every election performance in Indonesia since the beginning of Indonesian independence until the current era, it has always been nodai with dirty election violation practices. One example is the practice of money politics which has always been a shadow for the face of Indonesian democracy. Islam sees the concept of money politics as the same as the concept of risywah or bribery in a broad sense. Where both give rise to tyranny for other groups. There are so many impacts of this money politics practice, one of the most dominant is the increasing number of corruption, collusion, and nepotism in Indonesia. All those things are because of the money that has been spent to buy the people's vote. The way to prevent money politics is to increase the integrity of law enforcement officials in eradicating election violations and providing education to the public on the cause and effect if they receive money politics.
Dampak Poligami Tanpa Persetujuan Istri Terhadap Keharmonisan Rumah Tangga
Authors: Harahap Tuti Alawiyah , Siregar Syapar Alim
Published: May 2023

The focus of this research is the implementation of polygamy without the consent of the first wife which greatly affects household harmony in Sibanggor Tonga Village, Puncak Sorik Marapi District, Mandailing Natal Regency, by raising two main problems, namely 1) what is the background for polygamy without the wife's consent in the village. Sibanggor Tonga ? 2) What is the impact of polygamy without the wife's consent on the harmony of households practicing polygamy in Sibanggor Tonga Village?. The purpose of this study is to find out what is behind the occurrence of polygamy without the wife's consent and how it affects their household harmony.The approach used in this research is a qualitative-descriptive approach, namely collecting data through interviews, observations and document studies. This research is qualitative, namely research conducted by collecting primary data and secondary data on phenomena that are currently happening directly. The primary data from this research are the village head, community leaders and families who practice polygamy. And the secondary data in this research are books, journals, theses, and other supporting sources.The conclusion obtained in this study is that polygamous marriages that occurred in Sibanggor Tonga Village were carried out due to an error in understanding the verse that allowed polygamy, in which the emphasis of polygamy was only seen in terms of its permissibility, without paying attention to the permissibility of what is contained in the verse, on the basis of their common understanding of how polygamy is actually permitted by Islamic law and the law, and on the basis of abuse, in fact polygamy that occurred in Sibanggor Tonga Village is only used as a way to fulfill lust without considering the rights of the wife and children. their children so that it greatly affects the harmony of their household.
Koalisi Partai Nasionalis dan Partai Islam Pilkada Labuhan Batu Tahun 2020 Ditinjau Menurut Fiqh Siyasah
Authors: Nurhaliza Siti
Published: May 2023

This study examines the Implementation of the Nationalist Party and Islamic Party Coalition in the 2020 Labuhanbatu Regency Election, then the considerations made by the Nationalist Party and Islamic Party to Choose a Coalition in the Labuhanbatu Regency Election 2020. This research is a field study research with a qualitative approach, Data sources The primary ones are: the Prosperous Justice Party, the Indonesian Democratic Party of Struggle, the Hanura Party, the National Awakening Party and the KPU in the election of regional head candidates in Labuhanbatu Regency in 2020 and also the winning team for the pair H. Erik Atrada and Ellya Rosa. Secondary data sources are books and documents, observation data collection techniques, interviews and documentation, data analysis techniques using qualitative descriptive. The results of this study indicate that the formation of the coalition that was built between the Nationalist Party and the Islamic Party was not based on ideological similarities but, vision, mission and background as a candidate for Regent which became the basis for forming a coalition. In addition, the support of 20% from a combination of political parties is also one of the reasons for the formation of a coalition which is a requirement for candidacy through the Coalition route. The form of this coalition is a coalition that meets the KPU's requirements with the support of 20% of the DPRD seats.
Persepsi Masyarakat Terhadap Praktik Qordh Pada Masa Covid-19 Perspektif KHES
Authors: Harianja Nur Bayyina , Gunawan Syafri
Published: May 2023

This study discusses the lending and borrowing of money carried out by the people of Pangurabaan Village, Sipirok District, South Tapanuli Regency in terms of the Sharia Economic Law Compilation. This type of research is field research with a qualitative approach, the primary data source in this study is the community who practice lending to loan sharks in Pangurabaan Village. Secondary data sources are in the form of books, journals and documents related to this research. Data collection techniques through observation, interviews and documentation. The data analysis technique is a descriptive type of research. The results of the study showed that the factor that influenced the community to borrow money from loan sharks was education, the education of the people of Pangurabaan Village was still low. Second, the work of most people in Pangurabaan Village who carry out loan transactions with loan sharks are farmers/planters and also traders. Third, the lack of working capital. Fourth, the time needed to get money/business capital is faster and easier. Fifth, family economic factors that are not fulfilled. Not everyone can meet the financial value of his family.
Pelaksanaan Pemungutan Pajak Hotel di Padangsidimpuan Perspektif Fiqh Siayasah
Authors: Batubara Rahmat
Published: May 2023

This study examines the implementation of hotel taxes based on Law Number 04 of 2013 Article 8 concerning the Use of Local Taxes in Padansidimpuan. Taxes are people's contributions to the government and the money is used to build public facilities and help others. This type of research is in the form of field research or field research with a qualitative approach. Primary data sources come from employees of the Revenue Service and employees of the Padangsidimpuan City Hotel, while secondary data comes from related journal articles and books. Data collection techniques with interviews and documentation while data analysis techniques using descriptive qualitative. The results of this study are the implementation of regional regulations of the city of Padangsidimpuan no. 04 of 2013 article 08 regarding regional taxes in the city of Padangsidimpuan are as follows; The implementation of Hotel Tax Collection Based on Regional Regulation of Padangsidimpuan City No. 04 of 2013 Article 08 concerning Padangsidimpuan Regional Tax has not run optimally. This can be seen from the 6 hotels that were the subject of this study. There are two hotels that are late in making tax payments. Then, several obstacles to implementing hotel tax collection in Padangsidimpuan City, namely the lack of awareness of taxpayers about their responsibilities in paying taxes, sanctions that are not working properly. In addition, revenue service officers also do not socialize to taxpayers. A tax payment system that is too complicated makes it difficult for taxpayers to manage files related to taxpayer deposits. Third, regarding the review of siyasa fiqh, the scholars also recommend that tax collection in Indonesia must pay attention to rules such as Islamic law. Indonesia has not yet based its state ideology on Islamic law. Thus, it is necessary to have a thorough study to provide an explanation regarding the payment of taxes for Muslim communities in terms of siyasa fiqh.
PERLINDUNGAN HUKUM TERHADAP PEKERJA ANAK DALAM PERSFEKTIF UNDANG-UNDANG KETENAGAKERJAAN
Authors: Harahap Nurhotia
Published: May 2023

Discussing about children is a discussion that is always hotly discussed and has never been discussed throughout the history of life. Because children are the nation's generation and will be the successors of development, it means that the generation that has been prepared as a subject is like the implementation of a sustainable building and who will be the holder of control in the future of the State. Therefore, child protection is very meaningful so that the potential of resources and builds real human character towards a just and prosperous society. Related to the discussion about children, it is part of an investment that makes it an indicator of the success of a nation when working on its development in the future. The success of child development will certainly determine the potential of human resources in the future, so that it is the generation that will become the nation's successor so that they must be better prepared and directed from an early age so that they can grow and develop into children who are physically and mentally healthy, advanced, independent. and prosperous, become quality resources and can face challenges in the future.
Organización de la brigada separada
Authors: Murillo Arias Herbert
Published: May 2023

La Brigada Separada es la Unidad más operante para cumplir misiones independientes y por esto la importancia en el conocimiento de su organización, la cual redundará sin duda en el mejoramiento de conocimientos sobre este tipo de unidades.
Biochemical changes of rice genotypes against blast (Magnaporthe oryzae) disease and SSR marker validation for resistance genes
Authors: Yasmin Israt , Adhikary Sourov , Hassan Lutful , Sagor G.H.M.
Published: May 2023

Rice blast caused by Magnoporthe oryzae is a major devastating fungal disease and represents a potential threat to world rice productions. However, information about the genetic and biochemical basis of disease tolerance is still limited. In this study, we tested the presence and diversity of resistant R genes using SSR markers, and the antioxidant enzymes catalase (CAT), ascorbate peroxidise (APX) and guaicol peroxidise (POD), activity and also the concentration of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in resistant (BAUdhan 3) and susceptible (BRRIdhan 28) genotype. Molecular marker analysis reveals the presence of all ten studied resistant genes in BAUdhan 3. Among the markers studied, three markers namely RM224, RM72 and RM206 produce distinct band only in resistant genotype BAUdhan 3, which might be used to screen resistant genotypes. The enzymatic activity of APX, CAT and POD increased in the inoculated plant for both cultivars but the increase was more prominent for BAUdhan 3. The M. oryzae infections significantly increased the H2O2 content in BRRIdhan 28 and not much changed in BAUdhan 3. The MDA concentration was higher in the leaves of inoculated plants of BRRIdhan 28. The higher activities of APX and POD in the leaves of the inoculated plants of BAUdhan 3 resulted in lower H2O2 accumulation which can minimize the cellular damages possibly caused by reactive oxygen species. The result shows that the presence of more resistance genes and an effective antioxidative system in BAUdhan 3, which limits the damage caused due to fungal infection and thus contributes to greater resistance.
Effect of Wing Stiffness and Folding Wingtip Release Threshold on Gust Loads
Authors: Carrillo Córcoles Xavier , Mertens Christoph , Sciacchitano Andrea , van Oudheusden Bas W. , De Breuker Roeland , Sodja Jurij
Published: May 2023

This study presents an aeroelastic wind-tunnel experiment to identify the influence of the wing stiffness and hinge release threshold on the gust load alleviation performance of a folding wingtip design. Five models with different stiffness and tailoring properties are tested, and the wing root bending moment at different conditions is compared to the response with the locked-hinge condition to assess the impact on the gust load alleviation capabilities of the folding wingtip. The results show that the structural properties do not have an important impact on the peak load alleviation but the hinge release threshold and timing do. Releasing with the correct timing can reduce significantly the peak loads. However, the dynamics of the system are affected by this release; the flutter speed is decreased, and, although the performance can improve, load oscillations increase, which can be considered detrimental for reasons such as fatigue or passenger comfort.
Recent Applications of System Identification Techniques at IPEV
Authors: Dias Joaquim N. , Silva Bruno Giordano O.
Published: May 2023

This paper presents an overview of the system identification techniques developed and applied at the Flight Test and Research Institute during the last decade. System identification techniques have been used extensively to obtain aerodynamic models for a flight-test simulator, which was developed in house and specifically tailored for flight-test instruction and preparation for actual test flights. The methods applied were mostly the output error for data compatibility check and equation error in the time domain for model structure selection and parameter estimation. The most relevant applications are summarized in this paper, including identification of a high angle of attack model with compressibility effects for a jet trainer; estimation of drag polars at high subsonic regime for a jet fighter; identification of aerodynamic model in real-time for a propeller-driven fighter; application of flight-path reconstruction techniques to spin tests, in order to correct errors in the air data sensors; and identification of power effects on the longitudinal stability of a propeller-driven trainer. The examples show that system identification has become crucial to 1) obtain accurate aerodynamic models for training in the flight-test simulator and 2) develop more efficient flight-test techniques.
INFLUENCE OF SEASONAL CONDITIONS ON THE FAILURE RATE PARAMETER OF ELEMENTS OF THE KAMAZ-43118 ENGINE POWER SUPPLY SYSTEM
Authors:   Industrial University of Tyumen, Tyumen, Russia, Guselnikov A. S. , Zakharov N. S. ,   Industrial University of Tyumen, Tyumen, Russia
Published: May 2023

The reliability of the engine largely depends on the technical condition of the fuel equipment. It is known that the efficiency of cars depends on the operating conditions that change during the seasons of the year. The aim of the study is to establish the influence of seasonal operating conditions on the parameter of the failure rate of elements of the power supply system of KAMAZ-43118 car engines. The article presents a fragment of the research results. To achieve this goal, the theoretical part considers the factors affecting the reliability of the system under study. From the analysis of sources, it was found that with the change of the season of the year, road and transport conditions, natural and climatic factors significantly affect the food system. In this regard, the hypothesis of the study is put forward: natural and climatic factors significantly affect the reliability of the power supply system of KAMAZ-43118 car engines. At the first stage of experimental studies, statistical data on the operating time for failure of the power supply system of KAMAZ-43118 cars were processed, the elements of the system with the greatest number of failures were identified. At the second stage, the influence of air temperature on the parameter of the failure flow of the elements of the power supply system of KAMAZ-43118 car engines was established. With the help of correlation analysis, the significance of seasonal changes in natural and climatic factors is proved. At the third stage, a methodology for using the obtained data to adjust the volume of spare parts and materials in the warehouse is proposed. The scientific novelty of the research is to establish the regularities of the influence of air temperature on the parameter of the failure flow of fuel equipment elements of KAMAZ-43118 vehicles. The practical significance lies in the possibility of using the results of the study in the development of a methodology for optimizing the volume of spare parts and materials in the warehouse. Further research will be aimed at improving the reliability of the power supply system taking into account seasonal operating conditions by adjusting the frequency of maintenance.
INFLUENCE OF TRAFFIC FLOW PARAMETERS AND ROAD CHARACTERISTICS ON ROAD SAFETY
Authors:   Siberian Federal University, Krasnoyarsk, Russia, Baklanova K. V.
Published: May 2023

Despite the positive effect of the implementation of existing federal targeted programs and national projects in the field of road safety (RTS), the death rate on roads remains quite high. The article considers the current state of accidents, the dynamics of the development of the road network and the level of motorization over the past 10 years. The factors that determine the current state of accidents are identified. Based on the accident rate on the territory of the Krasnoyarsk Territory, it was revealed that the most serious road traffic accidents (RTA) occur on roads outside the city limits, a large percentage of accidents involving vehicles of categories M2, M3 and N. Based on the analysis of studies in the field of road safety assessment and statistical data, the purpose of the study is defined - to identify the impact of traffic flow parameters and road characteristics on road safety. The paper uses the methods of mathematical statistics, the content of which was determined in the course of a study of 20 sites on the FAD in the Krasnoyarsk Territory. For analysis, sections were selected that differ in the level of accidents, traffic flow characteristics and geometric parameters. As a result of a scientific study, it is mathematically confirmed that traffic safety is influenced by the composition of the traffic flow and the variational range of speeds between the overtaken and overtaking vehicles. The dependence of the variational range of speeds between the overtaken and overtaking vehicles on the composition of the traffic flow, the dependence of the partial accident rate coefficient K11 on the variational range of speeds between the overtaken and overtaking vehicles are determined. A regression model has been obtained for the dependence of the average annual number of accidents on the width of the shoulder, the radius of the curve in plan, visibility, the distance from the edge of the carriageway to a cliff with a depth of more than 5 m, the friction coefficient, the composition of the traffic flow, the variation range of speeds between the overtaken and overtaking vehicles. The scientific novelty of the study is the dependence of the average annual number of accidents on the traffic flow parameters and road characteristics. The practical significance of the study lies in the increase in traffic safety due to the use of the final accident rate method in its assessment, which takes into account the composition of the traffic flow and the variational range of speeds between the overtaken and overtaken vehicles. Further research is aimed at identifying yet unaccounted for factors influencing RTS.
WHO SAFE SURGERY CHECKLIST IMPLEMENTATION IN UKRAINE: MEDICAL PERSONNEL COMPLIENCE AND OTHER ASPECTS
Authors: BIELKA K. , KUCHYN I. , FRANK M. , SIRENKO I. , SAZHYN D. , FOMINA H.
Published: May 2023

Summary. WHO surgical checklist is an effective tool for human-related adverse perioperative event prevention. Although it’s implementation often accompanied by different challenges.

The objective of the study was to evaluate the quality of implementation of the modified WHO surgical checklist and to identify the main barriers to its completion.

Materials and methods. A retrospective analysis of 366 medical records of patients that undergoing a Cesarean section was performed during the period from 1 October 2022 to 5 January 2023 and the accompanying checklists to evaluate their completion.

Results. The average checklist completion rate was 94.2 %. The least filled field was “specimen labelling” and “date and time” in the final section (87.9%, n = 190), the most – patient identification, informed consent to anesthesia, presence of the relevant laboratory data and obstetric history, readiness of the anesthetic equipment, known allergies (100 %, n = 216). Among the checklists’ sections, fields were most unmarked in the “end of procedure” section (91.7 % filled), followed by the “preoperative assessment” (94.5 % filled) and most rarely in the “preinduction assessment” (95.5% filled).

Conclusion and recommendations. The results of the study indicate the average compliance of the medical staff to filling out the surgical checklist «Safe Surgery» in the Kyiv City Maternity Hospital No. 5, and the high completeness of the filled checklists. Failure to complete the checklist was most often associated with urgent surgical interventions. Analysis of compliance of medical personnel and the quality of filling out checklists is an important and mandatory component of improving the safety of surgery and anesthesia.
PHARMACOKINETICS AND PHARMACODYNAMICS OF PROPOFOL AND DEXMEDETOMIDINE DURING ELECTIVE PROCEDURAL SEDATIONS AND CHARACTERISTICS OF THEIR COMBINATION (LITERATURE REVIEW)
Authors: PYLYPENKO MAKSYM , MYKHAYLOV B.
Published: May 2023

In the previous publication, we outlined the general principles of procedural sedation (PS), the depth of suppression of consciousness and spontaneous motor activity, the minimum quantity of patients' pre-procedural examinations and the aspects of informed consent obtaining. The principles of vital signs monitoring, patients' immobilisation, and the detection and treatment of adverse events have been described. A key aspect of the PS is the readiness to ensure patency of the airways and oxygenation at least one level deeper than the existing level of the PS.

In this publication, attention is focused on the pharmacokinetics and pharmacodynamics of propofol and dexmedetomidine - the main drugs for elective PS and on the combination between them. In a future publication, we plan to characterize other key medications for PS, such as midazolam, ketamine, thiopental, and fentanyl.

Propofol is a short-track anaesthesia drug, and it was the most widely distributed in the 21st century because after its use patients quickly and fully regain consciousness. At the same time, to achieve the necessary deep level of sedation and prevent unintended movements of the patient, it is often required to use high doses of propofol that can cause clinically significant suppression of the patency of the upper respiratory airways, depth of breathing, and hemodynamic. Therefore, in this publication, we promote the implementation of multimodal sedation and analgesia with the use of moderate doses of several drugs, which allows a significant reduction in the dose of propofol and thus increase the safety of PS. Dexmedetomidine has both sedative and analgesic properties with a minimal effect on the patency of the upper airways and the depth of breathing, thus is the best drug to combine with propofol in PS.

In children, intranasal administration of dexmedetomidine and midazolam is an important alternative method of premedication, which provides a gentle entry into sedation and prevents the child's stress reactions to the placement of a venous catheter. Although the use of dexmedetomidine in children's practice is still "off-label" and outside the indications approved by the FDA in this publication we provide evidence to justify its safety and effectiveness of its usage in paediatrics PS.
EnzyKR: A Chirality-Aware Deep Learning Model for Predicting the Outcomes of the Hydrolase-Catalyzed Kinetic Resolution
Authors: Ran Xinchun , Jiang Yukunyao , Shao Qianzhen , Yang Zhongyue J.
Published: May 2023

Hydrolase-catalyzed kinetic resolution is a well-established biocatalytic process. However, the computational tools that predict the favorable enzyme scaffolds for separating racemic mixture are underdeveloped. To address this challenge, we trained a deep learning framework, EnzyKR, to automate the selection of hydrolases for stereoselective biocatalysis. EnzyKR adopts a classifier-regressor architecture that first identifies the reactive binding conformer of an enantiomer-hydrolase complex, and then predicts its activation free energy. A structure-based encoding strategy was used to depict the chiral interactions between hydrolases and enantiomers. EnzyKR was trained using 204 enantiomer-hydrolase complexes curated from IntEnzyDB, and was tested using a pre-split dataset of 20 complexes on the task of active free energy prediction. EnzyKR results in a Pearson R of 0.66, a Spearman R of 0.70, and an MAE of 1.48 kcal/mol. EnzyKR was further tested on the task of predicting enantiomeric excess ratios for 18 hydrolytic reactions catalyzed by fluoroacetate dehalogenase RPA1163 and halohydrin HheC, where the performance of EnzyKR was compared against a recently-developed kinetic predictor, DLKcat. EnzyKR outperformed the DLKcat in 13 out of 18 catalytic reactions. EnzyKR provides a novel computational strategy for an accurate prediction of enantiomeric outcome of hydrolase-catalyzed kinetic resolution reactions.
Machine Learning-Based Analysis of Molar and Enantiomeric Ratios and Reaction Yields Using Images of Solid Mixtures
Authors: Ide Yuki , Shirakura Hayato , Sano Taichi , Murugavel Muthuchamy , Inaba Yuya , Hu Sheng , Takigawa Ichigaku , Inokuma Yasuhide
Published: May 2023

Visual observations are frequently used as a preliminary evaluation of the chemical contents of mixtures, but their accuracy largely depends on the observer’s experience and intuition, which are difficult to share. Here, we report component ratio pre-diction using image-based machine learning (ML), which is applicable to analysis of various solid mixtures, such as mix-tures of organics and inorganics, polymorphous crystals, and enantiomers. The trained model with 300 images could predict the sugar/dietary salt weight ratio from an image within 4% error. The ML prediction pipeline was shown to be broadly ap-plicable to polymorphic glycine, D/L-tartaric acid, and four-component systems. As an application demonstration, we also used our ML system to analyze yield of a solid-state decarboxylation reaction. These results demonstrated that accumulation of researchers’ experience derived from visual information can be shared as trained ML models and used as a quantitative analysis method.
Parahydrogen-Polarized [1-13C]Pyruvate For Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging
Authors: Nagel Luca , Gierse Martin , Gottwald Wolfgang , Ahmadova Zumrud , Grashei Martin , Wolff Pascal , Josten Felix , Karaali Senay , Müller Christoph A. , Lucas Sebastian , Scheuer Jochen , Müller Christoph , Blanchard John , Topping Geoffrey J. , Wendlinger Andre , Setzer Nadine , Sühnel Sandra , Handwerker Jonas , Vassiliou Christophoros , van Heijster Frits H. A. , Knecht Stephan , Keim Michael , Schilling Franz , Schwartz Ilai
Published: May 2023

Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though the hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment limits its widespread use. Here, we demonstrate a polarization procedure of [1-13C]pyruvate based on parahydrogen-induced polarization by side-arm hydrogenation (PHIP-SAH) in an automated polarizer. It was benchmarked in a study with 48 animals against a commercial dissolution dynamic nuclear polarization (DNP) device. We obtained purified, concentrated (≈ 70-160 mM) and highly hyperpolarized (≈ 18 %) solutions of pyruvate at physiological pH for volumes up to 2 ml within 85 seconds in an automated process. The safety profile, image quality, as well as the quantitative perfusion and pyruvate-to-lactate ratios, were equivalent for PHIP and DNP, rendering PHIP a viable alternative to established hyperpolarization techniques.
Ni-Catalyzed Linearizable Cyclization/Alkylmetal Interception with Silicon-Oxygen as a Detachable Linker: Regioselective Access to 1,2-Oxasilolane Heterocycles, 3-Hydroxysilanes and 4-Arylalkanols
Authors: G. Lakomy Margaret , C. Del Rio Ava , Giri Ramesh
Published: May 2023

We disclose a Ni-catalyzed cyclization/alkylmetal interception reaction in which products are readily linearized to permit regiodefined alkene dicarbofunctionalization. This method offers a convenient route to access 1,2-oxasilolane heterocycles, 3-hydroxysilanes and 4-arylalkanols with the formation of C(sp3)-C(sp3) bonds at primary and secondary alkyl carbon centers. In this reaction, a silicon-oxygen (Si-O) bond functions as a detachable linker that can be delinked with several hydride, alkyl, aryl and vinyl nucleophiles to create profusely functionalized 3-hydroxysilanes. A silicon motif in the cyclic C(sp3)-Si-O construct in 1,2-oxasilolane heterocycles can also be selectively deleted by Pd-catalyzed hydrodesilylation affording Si-ablated linear alcohol products reminiscent of vicinal ethylene dicarbofunctionalization with C(sp3) and C(sp2) carbon sources.
Cardiovascular and Diabetes Risk in Preschoolers
Authors: Martha Nydia Ballesteros-Vásquez  , Saraí García-Gámez  , Elizabeth Artalejo-Ochoa  , Bianca Vargas-Tequida  , José Antonio Ponce-Martínez  , Alma Elizabeth Robles-Sardin  , María Isabel Grijalva-Haro  , Wang Xiao
Published: May 2023

Objective: To perform an exploratory analysis of possible alterations in clinical markers of cardiovascular risk and type 2 diabetes in preschoolers living in urban and suburban areas of the municipality of Hermosillo, Sonora, Northwest Mexico. Methods: An observational and cross-sectional study was carried out on children from urban and suburban areas. Their weight, height, waist circumference, body fat percentage, and blood pressure were measured, and their lipid profile, glucose, and insulin concentrations were evaluated. Results: Eighty-two children with an average age of five were included in the study; 48 from the conurbation and 34 from the urban area. We found that malnutrition, overweight, and high body fat percentage (27 ± 0.52) coexist. In the suburban area, there was a higher percentage of children with pre-hypertension and alterations in lipids: elevated triglycerides (35%) and low HDL-c (25%) (p < 0.01). In the urban area, there was a higher percentage of children with altered glucose (12%), elevated insulin concentrations, and insulin resistance. Conclusion: The findings of this study show that cardiovascular risk factors and type 2 diabetes are prevalent in children aged three to six living in urban and conurbation areas of Hermosillo, Sonora.
Comparison of the Effect of Clopidogrel and Ticagrelor on the Development of No-Reflow Phenomenon After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction
Authors: Yesil Emrah , Uyar Hakan , Örsçelik Özcan , Özkan Buğra , Çelik Ahmet , Türkay Özcan İsmail , Necdet Akkuş Mehmet
Published: May 2023

Background: No-reflow phenomenon (NRP) is one of the most important factors affecting myocardial reperfusion. Objective: In this study, we investigated the effect of ticagrelor and clopidogrel on the development of NRP in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: Our single-center, retrospective study included 200 patients with AMI who underwent PCI. The patients were divided into two groups according to the antiplatelet regimen given before PCI: clopidogrel- and ticagrelor-loaded groups. NRP was defined based on TIMI flow classification or post-procedural ST segment resolution. The difference in the parameters between patients with no-reflow and patients with normal flow as well as the effect of ticagrelor and clopidogrel on NRP were evaluated. Results: There was no difference in baseline characteristics between patients with no-reflow and patients with normal flow. The number of patients with ST-elevation myocardial infarction was higher in the ticagrelor-loaded group compared with the clopidogrel-loaded group (P = 0.013). Age, aspartate aminotransferase (AST), C-reactive protein (CRP), peak creatine kinase MB (CK-MB), diabetes mellitus (DM) rate, length of stent, number of stents, and number of patients with low ejection fraction were significantly higher in the no-reflow group compared with the normal flow group. The rate of NRP development was significantly lower in ticagrelor-loaded patients (19% P = 0.001), independent of other independent variables, including age, DM, AST, CRP level, number of stents implanted, and type of myocardial infarction (odds ratio = 0.228, 95% confidence interval = 0.102–0.512, P < 0.001). Conclusion: Ticagrelor is superior to clopidogrel in preventing the development of NRP.