bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of fermentation on the constituents in the branches and leaves of Taxus media and non-small cell lung cancer
Authors: Guo Xing , Wang Rui-Sheng , Zhang Zhen-Ling , Zhang Hong-Wei , Wang Sheng-Chao , Zhang Shuai , Wu Ya-Ning , Li Ya-Jing , Yuan Jun
Published: October 2024

Introduction

Non-small cell lung cancer (NSCLC) is a prominent lung cancer disease worldwide. Currently, commonly used methods, such as surgery and radiotherapy, have significant side effects. Traditional Chinese medicine (TCM) has become a research hotspot because of its safe and effective characteristics. The branches and leaves of Taxus media are abundant in antitumor active compounds, and there has been no research conducted as yet regarding its anti–lung cancer molecular mechanism.

Objective

The aim of this study is to investigate the antitumor activity of two samples before and after fermentation of T. media, and to research the molecular mechanism of its inhibitory effect on NSCLC.

Methods

The chemical composition of pre-fermentation T. media (TM) and post-fermentation T. media qu (TMQ) were investigated using UHPLC-Q-Qrbitrap HRMS and high-performance liquid chromatography (HPLC). The anti-lung cancer activities of TM and TMQ were compared using an A549-induced tumor mouse model. An enzyme-linked immunosorbent assay (ELISA), hematoxylin and eosin (H&E) staining, immunohistochemistry, and immunofluorescence were used to determine the of TMQ mechanism of action.

Results

The results indicated that TM and TMQ contained 83 compounds, consisting primarily of flavonoids, organic acids, and taxanes. Both taxanes and flavonoids in TMQ were higher than that in TM. Both TM and TMQ effectively inhibited the tumor growth in non-small cell lung cancer (NSCLC), and the inhibition rate was greater in TMQ (57.24%) than in TM (49.62%). TMQ administration downregulated the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the glutathione (GSH) level and upregulated interferon-γ (IFN-γ), reactive oxygen species (ROS), and malondialdehyde (MDA) levels in the serum of tumor mice. TMQ treatment also increased the protein expression of Bax, Caspase-3, and Beclin-1 in tumor tissues. In contrast, the bcl-2, PI3K, Ki67, ULK1, and mTOR protein levels were suppressed by TMQ. Protein assay analyses reemphasized the superior antitumor effect of TMQ over TM. These cumulative findings demonstrated that the mechanism of action of TMQ was closely related to the activation of transcriptional misregulation in the cancer pathway that inhibited the cholinergic synaptic, AMPK, and PI3K/Akt/mTOR signaling pathways.

Conclusion

This study demonstrated that fermentation increased the active ingredient contents and antitumor effects of T. media. In addition, post-fermentation TMQ was superior to TM as a herbal medicine for NSCLC treatment.
Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology
Authors: Zou Yutao , Chen Jiayi , Luo Xuanxuan , Qu Yijie , Zhou Mengjiao , Xia Rui , Wang Weiqi , Zheng Xiaohua
Published: October 2024

Photodynamic therapy and ferroptosis induction have risen as vanguard oncological interventions, distinguished by their precision and ability to target vulnerabilities in cancer cells. Photodynamic therapy’s non-invasive profile and selective cytotoxicity complement ferroptosis’ unique mode of action, which exploits iron-dependent lipid peroxidation, offering a pathway to overcome chemoresistance with lower systemic impact. The synergism between photodynamic therapy and ferroptosis is underscored by the depletion of glutathione and glutathione peroxidase four inhibitions by photodynamic therapy-induced reactive oxygen species, amplifying lipid peroxidation and enhancing ferroptotic cell death. This synergy presents an opportunity to refine cancer treatment by modulating redox homeostasis. Porphyrin-based nanoscale metal-organic frameworks have unique hybrid structures and exceptional properties. These frameworks can serve as a platform for integrating photodynamic therapy and ferroptosis through carefully designed structures and functions. These nanostructures can be engineered to deliver multiple therapeutic modalities simultaneously, marking a pivotal advance in multimodal cancer therapy. This review synthesizes recent progress in porphyrin-modified nanoscale metal-organic frameworks for combined photodynamic therapy and ferroptosis, delineating the mechanisms that underlie their synergistic effects in a multimodal context. It underscores the potential of porphyrin-based nanoscale metal-organic frameworks as advanced nanocarriers in oncology, propelling the field toward more efficacious and tailored cancer treatments.
Precise and accurate speed measurements in rapidly flowing dense suspensions
Authors: Moghimi Esmaeel , Blair Daniel L. , Urbach Jeffrey S.
Published: October 2024

We introduce a method for precise and accurate measurements of particle speeds in dense suspensions flowing at high rates and demonstrate the utility of the approach for revealing complex flow fluctuations during shearing in a setup that combines imaging with a confocal microscope and shearing with a rheometer. We scan the focal point in one dimension, aligned with direction of flow, producing absolute measurements of speed that are independent of suspension structure and particle shape. We compare this flow-direction line scanning approach with a complementary method we introduced previously, measuring speed using line scanning in the vorticity direction. By comparing results in various flow conditions, including shear-thinning and thickening regimes, we demonstrate the efficacy of our new approach. We find that both approaches exhibit qualitatively similar flow profiles, but a comparative analysis reveals a 15%–25% overestimation in speed measurement using vorticity line scanning, with discrepancies generated by anisotropic suspension microstructure under flow. Moreover, in the thickening regime where complex flow fields are present, both approaches capture local speed fluctuations. However, line scanning in the flow direction reveals and precisely captures stagnation and backflows, a capability not achievable with vorticity line scanning. The approach introduced here not only provides a refined technique for speed measurement in fast-flowing suspensions but also emphasizes the significance of accurate measurement techniques in advancing our understanding of flow behavior in dense suspensions, particularly in contexts where strong non-affine flows are prevalent.
CLE peptide signaling in plant-microbe interactions
Authors: Nakagami Satoru , Kajiwara Taiki , Tsuda Kenichi , Sawa Shinichiro
Published: October 2024

Cell-cell communication is essential for both unicellular and multicellular organisms. Secreted peptides that act as diffusive ligands are utilized by eukaryotic organisms to transduce information between cells to coordinate developmental and physiological processes. In plants, The CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) genes encode a family of secreted small peptides which play pivotal roles in stem cell homeostasis in various types of meristems. Accumulated evidence has revealed that CLE peptides mediate trans-kingdom interactions between plants and microbes, including pathogens and symbionts. This review highlights the emerging roles of CLE peptide signaling in plant-microbe interactions, focusing on their involvement in nodulation, immunity, and symbiosis with arbuscular mycorrhizal fungi. Understanding these interactions provides insights into the sophisticated regulatory networks to balance plant growth and defense, enhancing our knowledge of plant biology and potential agricultural applications.
An effective approach to tackling complex health policy challenges. Using a clinical microsystems approach and rethinking codesign
Authors: Duggan M. , Dunbar J. A. , Morgan M. A. , Mc Namara K. P. , de Courten M. P. , Calder R. V.
Published: October 2024

That people with serious mental illness have poor physical health and face a significant life expectancy gap compared with the general population is well known. Despite considerable policy focus in some countries, the gap in life expectancy remains. Tackling complex and persistent health problems such as this requires a systems-based approach, recognising the complexity of interacting components and their effects on the problem and on each other and applying collaborative analysis, design and implementation by those with knowledge of and expertise in the problem and the context. This paper describes the methods used to develop the Australian Being Equally Well National Policy Roadmap for better physical health care and longer lives for people with severe mental illness. Whilst recognising that high rates of physical health comorbidities are caused by many factors including lifestyle, access to high-quality healthcare and medication side effects, the work was focused on what could be done within Australian primary care to improve the physical health of this cohort. A Clinical Microsystem Approach was applied to synthesise clinical evidence with professional and lived experience, and an innovative policy development process was established, creating trust across all system levels. Participants with different kinds of knowledge and experience worked in discrete groups according to their professional or expert role whilst also being supported to participate in an intensive cross-collaboration. The potential value of this methodology for tackling other complex problems in health policy is discussed.
Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019
Authors: Qian Hang , Shang Weifeng , Zhang Sheng , Pan Xiaojun , Huang Sisi , Li Hui , Wen Zhenliang , Liu Jiao , Chen Dechang
Published: October 2024

Background

Maternal sepsis and other maternal infections (MSMIs) are major public health concerns worldwide. However, comprehensive data on their global burden and evolving trends remain sparse. This study aims to explore the epidemiological trends of MSMIs in women of childbearing age (WCBA) from 1990 to 2019, investigate the relationship between disease burden and age, period, and birth cohorts, and then provide a prediction of MSMIs incidence and deaths.

Methods

The estimates and 95% uncertainty intervals (UIs) for the incidence and death number of MSMIs in seven age groups (15–19, 20–24, 25–29, 30–34, 35–39, 40–44, 45–49 years) were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The age-standardized incidence and mortality rates of MSMIs in WCBA were estimated utilizing the age standardization by direct method. Joinpoint regression analysis was employed to investigate the changing trends of age-standardized incidence and mortality rates from 1990 to 2019. Age-period-cohort analysis was utilized to estimate the independent effects of age, period, and birth cohorts. Furthermore, a Nordpred age-period-cohort analysis was implemented to predict the global epidemiological trends through 2044.

Results

In 2019, the estimated global age-standardized incidence and mortality rates of MSMIs in WCBA were 1072.90 (95% UI: 725.93 to 1483.46) and 0.86 (95% UI: 0.69 to 1.05), respectively. The highest disease burden existed in the African Region. From 1990 to 2019, the estimated global age-standardized incidence and mortality rates of MSMIs (AAPC: -1.32, 95% CI: −1.34 to −1.30; AAPC: -3.39, 95% CI: −4.28 to −2.48) in WCBA both demonstrated significant declining trends. The changing trends varied significantly across 6 regions and 204 countries. The effects of age, period, and cohort on incidence and mortality rates differed. From 2020 to 2044, the global age-standardized incidence rate of MSMIs in WCBA was predicted to decrease whereas the case number increases slowly.

Conclusion

The global trends in MSMIs incidence and mortality generally showed a decline with considerable heterogeneity, indicating both the effectiveness and unevenness of global management of MSMIs. Moreover, the predicted increased case number highlights prominent challenges in the control of MSMIs.
Analysis of the interrelationship between precipitation and confirmed dengue cases in the city of Recife (Brazil) covering climate and public health information
Authors: Borges Iuri Valerio Graciano , Musah Anwar , Dutra Livia Marcia Mosso , Tunali Merve , Lima Clarisse Lins , Tunali Mehmet Meric , da Silva Ana Clara Gomes , Aldosery Aisha , Moreno Giselle Machado Magalhães , dos Santos Wellington P. , Massoni Tiago , Yenigün Orhan , Kostkova Patty , da Rocha Rosmeri Porfirio , Campos Luiza C. , Ambrizzi Tercio
Published: October 2024

Large-scale epidemics of arboviruses, such as dengue, have heightened societal awareness regarding the necessity of combating the primary transmission vectors. Equally critical is the identification of environmental conditions and variables that influence vector population dynamics. Aedes aegypti, the primary vector of arboviruses such as dengue and Zika in Brazil, is closely associated with the climatic and geographical conditions of urban environments. This study examines the relationship between precipitation and confirmed dengue cases in Recife (Brazil), employing regression and quantile analyses to evaluate the influence of meteorological conditions on the disease’s spread. The findings reveal a direct correlation between monthly averages of precipitation and confirmed cases, although this is apparent only when excluding years of epidemic peaks. The highest number of cases generally aligns with the rainy season, and the lowest with the dry season, with weak, moderate and strong precipitation events being closely linked to increased dengue incidence. However, notable discrepancies were identified: four out of six major outbreaks occurred in drier months, challenging the assumption of a straightforward relationship between rainfall and dengue incidence. These findings underscore the multifaceted nature of dengue dynamics, suggesting that while precipitation plays a significant role, other factors, including serotype circulation and broader climatic phenomena, are equally critical in driving outbreaks. This complexity highlights the need for a more comprehensive understanding of the mechanisms influencing dengue epidemics.
A fast temporal multiple sparse Bayesian learning-based channel estimation method for time-varying underwater acoustic OFDM systems
Authors: Zou Sichen , Jia Shuyang , Zhang Xiaochuan , Liu Baoheng
Published: October 2024

In this paper, a fast temporal multiple sparse Bayesian learning (FTMSBL)-based channel estimation method for underwater acoustic (UWA) orthogonal frequency division multiplexing (OFDM) systems is proposed, which is optimized using the fast marginalized likelihood maximization method. The algorithm fully uses the consistent sparse structure and time-domain correlation properties of channels to improve the reconstruction performance and computational efficiency, offering better performance and higher computational efficiency than the traditional Bayesian learning algorithms. At the same time, the FTMSBL algorithm does not require computing the inverse of large matrices and consumes very little storage resources in the operation, making it suitable for hardware implementation. Simulation and sea trial results show that the FTMSBL-based underwater channel estimation algorithm achieves higher channel estimation accuracy than the orthogonal matching tracking algorithm, and the system bit error rate (BER) is significantly reduced; specifically, the FTMSBL algorithm can achieve optimal performance in strong time-dependent channels.
Tackling the multitude of uncertainties in energy systems analysis by model coupling and high-performance computing
Authors: Frey Ulrich J. , Sasanpour Shima , Breuer Thomas , Buschmann Jan , Cao Karl-Kiên
Published: October 2024

This paper identifies and addresses three key challenges in energy systems analysis—varying assumptions, computational limitations, and coverage of a few indicators only. First, results depend strongly on assumptions, i.e., varying input data. Hence, comparisons and robust results are hard to achieve. To address this, we use a broad range of possible inputs through an extensive literature review by scenario experts. Second, we overcome computational limitations using high-performance computing (HPC) and an automated workflow. Third, by coupling models and developing 13 indicators to evaluate the overall quality of energy systems in Germany for 2030, we include many aspects of security of supply, market impact, life cycle analysis and cost optimization. A cluster analysis of scenarios by indicators reveals three recognizable clusters, separating systems with a high share of renewables clearly from more conventional sets. Additionally, scenarios can be identified which perform very positive for many of the 13 indicators. We conclude that an automated, coupled workflow on supercomputers based on a broad parameter space is able to produce robust results for many important aspects of future energy systems. Since all models and software components are released as open-source, all components of a multi-perspective model-chain are now available to the energy system modeling community.
Child and adolescent sleep disturbances and psychopathology in a mental health clinic sample
Authors: Blacher Aviva , McKenzie Katarina N. A. , Stewart Shannon L. , Reid Graham J.
Published: October 2024

Introduction

Children and adolescents treated in specialty mental health services are more likely to have sleep disturbances than those without mental health problems. Few studies have investigated the relationship between sleep and psychopathology in broad clinical samples of children. We examined the relationship between sleep disturbance and age on internalizing and externalizing psychopathology in a sample who sought treatment at children's mental health centers.

Methods

Secondary data analyses were completed on a sample of children (N = 13,472; aged 4 to 18; 55% male) from 39 children's mental health agencies in Ontario, Canada, who completed a semi-structured assessment, the interRAI Children and Youth Mental Health (ChYMH). A split-half sample approach was utilized (S1 n = 6,773, S2 n = 6,699). Hierarchical regressions examined the effects of sleep disturbances (i.e., difficulty falling asleep, staying asleep, night waking, bedtime resistance, falling asleep during the day) on internalizing and externalizing symptoms, above and beyond established child- (i.e., age, sex, sensory sensitivity, pain) and family-level variables (family functioning, caregiver distress, parenting strengths). Age was tested as a moderator for sleep disturbances on both outcome variables.

Results

Overall, 6.7% of children had clinically significant sleep disturbance scores (≥10 out of 16) on the interRAI ChYMH. In both samples, sleep disturbances predicted internalizing (S1 ΔR2 = 10%, S2 ΔR2 = 10%) and externalizing symptoms (S1 ΔR2 = 2%, S2 ΔR2 = 1%), above and beyond child and family variables. Age moderated the relationship between sleep disturbances and internalizing symptoms (S1 ß = 0.07; S2 ß = 0.07; ΔR2 = 0.004 in both samples), but not externalizing symptoms; sleep disturbance was more strongly related to internalizing symptoms amongst adolescents (ß = 0.98) than children (ß = 0.62).

Discussion

The relationship between sleep and internalizing symptoms appears to change as children move through development. Further, sleep was a stronger predictor of internalizing problems in adolescents than children, suggesting an additional focus of clinician efforts in this age group. These findings strengthen the importance of routine assessment of sleep, as is done with the interRAI ChYMH.
Who is the next leader? Understanding women leadership development and succession planning in Saudi Arabian higher educational institutions
Authors: Dahlan Dina Abdullah
Published: October 2024

Leadership development and succession planning is a valuable strategy for closing the gender gap and providing an equal chance for males and females to be trained and involved in leadership roles. This strategy is an incredibly effective tool in higher education, where there is a significant disparity between male and female academic leaders. Despite its effectiveness, succession planning remained an overlooked component of the higher education system. Further research studies enhance our understanding of the current state of succession planning and the factors that affect the recruitment and selection of future academic leaders. Hence, this study aims to identify the current women’s leadership development and succession planning practices in public and private universities in Saudi Arabia. A qualitative study was conducted in a Saudi Arabian higher education setting. The interest in Saudi Arabia stems from the fact that succession planning is less likely to be practiced since gender discrimination is apparent when assigning leadership positions. Results indicate that top powers typically select leaders since succession planning is absent in Saudi Arabia’s higher education institutions. In this circumstance, networking and relationships play a significant role, as these institutions have no formalized succession planning process. In a highly gender-segregated society like Saudi Arabia, women are deprived of expanding their networks and showcasing capabilities to male decision-makers. The results of this study further identified the underlying components of the women’s leadership and succession planning process in the Saudi Arabian setting. This study contributes to leadership and succession planning knowledge and its implications, which may extend opportunities for practitioners, consultants, and policymakers to include women in higher education succession planning.
Effect of summer legume residue incorporation and fertilizer regimes on rice growth, yield, and nutrient uptake
Authors: Sunil Kumar T. , Virdia H. M. , Patel K. G. , Ragi Shridhar , Chowdhury Manojit , Kumar Pradeep , Elbagory Mohssen , Omara Alaa El-Dein , Salem Ali , Elbeltagi Ahmed , El-Shinawy Doaa M.
Published: October 2024

In a field trial at the College Farm, NAU, Navsari (Gujarat), evaluated four main plot treatments (T1: Green gram, T2: Cowpea, T3: Dhaincha, and T4: Fallow), which were grown during the summer with three replications following a randomized block design (RCBD). Green gram and cowpea were incorporated into the soil after harvest, but dhaincha was incorporated at 50% flowering. During Kharif, each main plot was split into six smaller plots with different treatments: W1 was 100% RDF, W2 was 75% RDF, W3 was 50% RDF, W4 was 75% RDF + 25% N from FYM, W5 was 50% RDF + 50% N from FYM, and W6 was no fertilizer. The results of all 24 treatment combinations were repeated three times in a split-plot design. The analysis showed significant growth, yield attributes, grain yield, and straw yield of rice in dhaincha-incorporated plots (T3), fb greengram (T1), and cowpea (T2) plots using 100% RDF, while fallow (T4) with no fertilizer application recorded significantly lower values. SPAD meter readings of rice were higher in W4 (75% RDF + 25% N from FYM), which was at par with W1 in dhaincha-incorporated plots (75% RDF + 25% N from FYM) (W4). However, applying no fertilizer (W6) resulted in lower values. The total uptake of nitrogen and phosphorus in rice was highest when it was grown in dhaincha incorporated (T3), followed by green gram (T1), cowpea (T2) incorporated plots with the usage of 100% RDF (W1) and 75% RDF + 25% N from FYM (W4), and lower values were recorded in fallow + no fertilizer treatment (T4W6). Our study revealed that incorporating summer legumes before planting rice significantly increased plant height, tillers, grain and straw yield, and total uptake. With dhaincha, inclusion has shown a greater advantage.
Effects of guanidine acetic acid supplementation from gestation to lactation on reproductive performance, colostrum quality, blood biochemistry, and intestinal microflora diversity of sows
Authors: Cong Guanglei , Xia Shuangshuang , Liu Chunxue , Li Junbo , Hung Ifen
Published: October 2024

This experiment aimed to study the effects of guanidine acetic acid (GAA) on reproductive performance, lactation performance and blood biochemical indices of sows, as well as the performance of offspring piglets. A total of 20 sows (Landrace × Yorkshire, parity 4) were used. Half of the sows in each parity were fed a control diet (CG; basic diet, n = 10) or GAA diet (basic diet +1 g/kg GAA, n = 10) from the 85th day of gestation until weaning. The study results are presented as follows: Supplementation of GAA from late gestation to lactation did not adversely affect sow feed intake, backfat thickness, or blood routine indexes (p > 0.05). GAA supplementation showed a tendency to increase the number of healthy piglets and their birth activity (p = 0.06; p = 0.08), while significantly increasing the IUGR score of piglets (p < 0.05). GAA supplementation significantly increased colostrum protein content (p < 0.05) and tended to increase daily milk yield in sows (p = 0.07). GAA supplementation increased the level of immunoglobulin A in sow colostrum (p < 0.05) and showed a tendency to increase proline content (p = 0.10). GAA supplementation significantly decreased triglyceride content in sow cord blood (p < 0.05), with no significant effects observed on HDL-C, LDL-C, TC, and GLU (p > 0.05). GAA supplementation significantly increased eNOS levels in sow cord blood (p < 0.05), while showing no significant effects on IL-6 and IL-10 (p > 0.05). GAA supplementation did not significantly affect the α diversity of sow intestinal flora (ACE, Shannon, Chao1, Simpson, observed_otus, pielou_e, and good_cover), but PCoA analysis revealed differences in intestinal flora structure between groups. Additionally, GAA decreased the relative abundance of Sarciha and unidentified_ruminococcaceae and increased the relative abundance of Lactobacillus, Parabacteroides, and Pedobacter in the gut. GAA boosts nitric oxide synthase in sows’ umbilical cord blood, enhancing placental blood vessel development. This improves piglet health and vitality, increases beneficial gut bacteria (Lactobacillus, Parabacteroides, Pedobacter), and raises colostrum protein levels and lactation volume, leading to better piglet growth and performance.
Colistin–niclosamide-loaded nanoemulsions and nanoemulsion gels for effective therapy of colistin-resistant Salmonella infections
Authors: Zhang Junkai , Wang Xilong , Li Pengliang , Gao Yanling , Wang Ruiyun , Li Shuaihua , Yi Kaifang , Cui Xiaodie , Hu Gongzheng , Zhai Yajun
Published: October 2024

Colistin (COL) is regarded as a last-resort treatment for infections by multidrug-resistant (MDR) Gram-negative bacteria. The emergence of colistin-resistant Enterobacterales poses a significant global public health concern. Our study discovered that niclosamide (NIC) reverses COL resistance in Salmonella via a checkerboard assay. However, poor solubility and bioavailability of NIC pose challenges. In this study, we prepared a self-nanoemulsifying drug delivery system (SNEDDS) co-encapsulating NIC and COL. We characterized the physicochemical properties of the resulting colistin–niclosamide-loaded nanoemulsions (COL/NIC-NEs) and colistin–niclosamide-loaded nanoemulsion gels (COL/NIC-NEGs), assessing their antibacterial efficacy in vitro and in vivo. The COL/NIC-NEs exhibited a droplet size of 19.86 nm with a zeta potential of −1.25 mV. COL/NIC-NEs have excellent stability, significantly enhancing the solubility of NIC while also demonstrating a pronounced sustained-release effect. Antimicrobial assays revealed that the MIC of COL in COL/NIC-NEs was reduced by 16–128 times compared to free COL. Killing kinetics and scanning electron microscopy confirmed enhanced antibacterial activity. Antibacterial mechanism studies reveal that the COL/NIC-NEs and COL/NIC-NEGs could enhance the bactericidal activity by damaging cell membranes, disrupting proton motive force (PMF), inhibiting multidrug efflux pump, and promoting oxidative damage. The therapeutic efficacy of the COL/NIC-NEs and COL/NIC-NEGs is further demonstrated in mouse intraperitoneal infection models with COL-resistant Salmonella. To sum up, COL/NIC-NEs and COL/NIC-NEGs are a potentially effective strategies promising against COL-resistant Salmonella infections.
Nacjonalizm jako nieoczywisty konstrukt serbskiego myślenia politycznego w XIX–XX wieku
Authors: Dymarski Mirosław
Published: October 2024

Wars in former Yugoslavia diffused an opinion that Serbs are nationalists, and that attitude always characterized this nation. This article investigates, if the opinion is true or it is misuse. It is necessary, to ask questions about the sources of Serbian nationalism; both – on the historical level, as well as on the linguistic level. Which words are used in Serbian language for describing nation, and the other terms related to it? When could the Serbian nationalism originated, and when in the Serbian politics appeared the word nationalism? In pertain to the subject, the article investigates three periods: XIX century; The Kingdom of Serbs, Croats, and Slovenes, and the Tito’s Yugoslavia until it’s disintegration.
A Design Method for Road Vehicles with Autonomous Driving Control
Authors: Mao Chunyu , He Yuping , Agelin-Chaab Martin
Published: October 2024

The past three decades have witnessed extensive studies on motion-planning and tracking-control for autonomous vehicles (AVs). There is, however, a lack of studies on effective design methods for AVs, which consist of the subsystems of the mechanical vehicle, tracking-control, motion-planning, etc. To tackle this problem, this paper proposes a design approach for AVs. The proposed method features a design framework with two layers: at the upper layer, a particle swarm optimization (PSO) algorithm serves as a solver to a multi-objective optimization problem for desired AV trajectory-tracking performance; at the lower layer, a coupled dynamic analysis is conducted among the three subsystems, i.e., a nonlinear model for the mechanical vehicle, a motion-planning module, and a controller based on nonlinear model predictive control (NLMPC) for direction control. The simulation results demonstrate that the proposed method can effectively determine the desired design variables for the NLMPC controller and the mechanical vehicle to achieve optimal trajectory-tracking performance. The research findings from this work provide guidelines for designing AVs.
Modelling and Transmission Characteristics Analysis of APU Pneumatic Servo System
Authors: Yang Fang , Wang Mengqi , Liu Yang , Guo Zipeng , Yue Lingyun
Published: October 2024

The auxiliary power unit (APU), which is a compact gas turbine engine, is employed to provide a stable compressed air supply to the aircraft. This compressed air is introduced into the various aircraft components via the pneumatic servo system, thereby ensuring the normal operation of the aircraft’s systems. The objective of this study is to examine the impact of parameter variation on the transmission characteristics of an APU pneumatic servo system, with a particular focus on the aerodynamic moment associated with the operating process of a butterfly valve. To this end, a mathematical model of the pneumatic servo system has been developed. The accuracy of the mathematical model was verified by means of numerical simulation and comparative analysis of experiments. The simulation model was established in the Matlab/Simulink environment. Furthermore, the effects of throttling area ratio, fixed throttling hole diameter, rodless chamber volume of actuator cylinder and gas supply temperature on the transmission characteristics of the system were discussed in greater detail. The findings of the research indicate that the throttle area ratio is insufficiently sized, which results in a deterioration of the system’s linearity. Conversely, an excessively large throttle area ratio leads to a reduction in the controllable range of the load axis and is therefore detrimental to the servo mechanism of the flow control. An increase in the diameter of the fixed throttling hole or a decrease in the volume of the rodless cavity of the actuator cylinder facilitates a rapid change in flow rate within the rodless cavity and an increase in the response speed of the load-rotating shaft of the servomechanism. An increase in the temperature of the gas supply from 30 °C to 230 °C results in a reduction in the response time of the system by a mere 0.2 s, which has a negligible impact on the transmission characteristics of the system.
Extraction of Canal Distribution Information Based on UAV Remote Sensing System and Object-Oriented Method
Authors: Huo Xuefei , Li Li , Yu Xingjiao , Qian Long , Yin Qi , Fan Kai , Pi Yingying , Wang Yafei , Wang Wen’e , Hu Xiaotao
Published: October 2024

At present, the extraction of irrigation canal network distribution information is of great significance for developing a digital twin irrigation district. However, due to the low resolution of remote sensing images, it is difficult to effectively identify the canal networks, especially for channels with a width of less than 1 m, where recognition is insufficient. Therefore, the purpose of this study is to extract canal networks of different widths in an irrigation district in Shaanxi Province as the research area. A rule-based object-oriented classification method was employed, utilizing image data collected by the DJI Mavic 3 multispectral UAV (Unmanned Aerial Vehicle) to explore the accuracy of this method in extracting canal distribution information. Based on UAV multispectral remote sensing imagery, the segmentation parameters for the remote sensing imagery were determined using ENVI 5.6 software, with the segmentation threshold set at 60 and the merging threshold set at 80. By combining the spectral and spatial differences between the canals and other ground objects, rules for extracting canal network distribution information were established, and the information on the distribution of channels in this irrigation area was finally obtained. The experimental results showed a maximum recall rate of 91.88% and a maximum precision rate of 57.59%. The overall recall precision rates for the irrigation district were 85.74% and 55.08%, respectively. This method provides a new solution for identifying and extracting canal systems in irrigation districts, offering valuable insights for acquiring canal distribution information and providing a scientific basis for precision irrigation.
Essential Oils, Chemical Compounds, and Their Effects on the Gut Microorganisms and Broiler Chicken Production: Review
Authors: Salinas-Chavira Jaime , Barrios-García Hugo Brígido
Published: October 2024

The influence of essential oils (EOs) on gut microorganisms and broiler chicken production was evaluated through the systematic analysis of scientific reports. The present study was focused on the EO antimicrobial activity oriented toward broiler chicken production. There is a great biodiversity of plants, and various compounds with different biological activity have been isolated from them. The EO molecules extracted from plants have been employed recently in livestock feeding. Microbial resistance to antibiotics has led to their reduced use in animal production. To maintain competitive broiler chicken production with reduced antibiotic use, EOs have been explored. In broiler chickens, EOs are supplemented in the diet or drinking water to enhance weight gain and feed efficiency and reduce mortality. EOs are an alternative to antibiotics, and their research is dynamic in poultry production. The present review focused on the antimicrobial activity oriented to broiler chicken production. The search for information in databases used the terms “broiler chicken”, “essential oils” and combined them with the name of the plants. It was detected that the EO of Cinnamon bark or its compound cinnamaldehyde could reduce pathogenic bacteria in the digestive tract and improve intestinal morphology. Essential oils from Cymbopogon spp. and Origanum vulgare had an effect mainly against Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella spp., and others, and against some Gram-positive bacteria, such as Staphylococcus spp., or yeasts, such as Candida albicans. Essential oils of Cymbopogon citratus acted against Salmonella. Citrus japonica affected Bacillus subtilis, Escherichia coli, and Salmonella typhimurium. Origanum EO improved the antioxidant status and gut health of chickens, while EO of Eucalyptus with carvacrol, thymol, and Citrus lemon improved the productive performance of broiler chickens; also, Citrus spp. reduced the number of oocysts of Eimeria and showed activity against Listeria monocytogenes, Staphylococcus aureus, and Pseudomonas aeruginosa. It is concluded that EOs are a sustainable alternative to antibiotics in the production of broiler chickens. Future research includes the standardization of EO from different plants and active molecules, as well as the interaction with other feed additives and their impact on the health and production of broiler chickens. In addition, safety for consumers and the environment must be considered.
Industrial Agglomeration, Land Consolidation, and Agricultural Energy Inefficiency in China: An Analysis Using By-Production Technology and Simultaneous Equations Model
Authors: Xu Biaowen , Chen Xueli
Published: October 2024

Improving agricultural energy inefficiency is essential for achieving sustainable agricultural development and promoting major agricultural countries to achieve carbon peak and carbon neutrality goals. This paper analyzes agricultural energy inefficiency in China, using panel data from 30 provinces between 2000 and 2021. The by-production technology model is employed to measure and decompose inefficiency, and the simultaneous equations model and moderating effect model are utilized to study the impact mechanism of industrial agglomeration, land consolidation, and agricultural energy inefficiency. The findings reveal several key points: First, the average inefficiency of agricultural energy in China increased from 0.370 to 0.514, with economic inefficiency rising at a faster rate than environmental inefficiency. Second, agricultural industrial agglomeration serves to inhibit both agricultural energy economic inefficiency and environmental inefficiency, which, in turn, hampers the development of industrial agglomeration. This relationship shows heterogeneity across the eastern, central, and western regions, as well as between major and non-major grain production areas. Third, land consolidation—both nationally and specifically in the central, major grain-producing, and non-major grain-producing areas—effectively mitigates the deterioration of agricultural energy inefficiency caused by industrial agglomeration. In the eastern region, land consolidation can enhance the inhibitory effect of industrial agglomeration on energy inefficiency. This paper highlights the interconnections between industrial agglomeration, land consolidation, and agricultural energy inefficiency, providing valuable policy references for the development of sustainable agriculture and the proactive and steady advancement of carbon peak and carbon neutrality goals.
Identification of Technical Requirements for the Initial Design of an Autonomous Fruit-Harvesting Robot
Authors: Salazar Maxwell , Portero Paola , Rubin Juan
Published: October 2024

Automation in agriculture is revolutionizing the management of field tasks. This paper focuses on identifying the essential needs and preliminary technical requirements for designing an autonomous robot specifically for fruit harvesting. The study examines the integration of advanced machine vision technologies and neural networks for the accurate detection of ripe fruits and obstacles, optimizing harvesting efficiency. Key features such as proximity and touch sensors are also evaluated to ensure the safe handling of fruits, minimizing damage during harvesting. The technical specifications, including traction, speed, and the robot’s ability to operate on uneven terrain, are analyzed to ensure adaptability across various crops and ground conditions. Perception systems, incorporating cameras and sensors, are crucial for crop inspection and route planning. The main findings of this review establish a set of technical requirements that serve as a foundation for developing efficient and economically viable fruit-harvesting robots. These systems offer significant potential to transform agriculture by addressing labor shortages and improving harvesting precision. However, challenges remain, particularly in adapting to diverse crops and environments, emphasizing the need for further research and development.
Evaluating the Effectiveness of the Biodegradable Superabsorbent Polymer (Fasal Amrit) on Soil Hydrological Properties: A Laboratory Rainfall Simulation Study
Authors: Ruwanpathirana P. P. , Sakai Kazuhito , Nakandakari Tamotsu , Yuge Kozue
Published: October 2024

Superabsorbent polymers (SAPs) are effective soil amendments that can control soil erosion by improving soil quality. However, many commercial SAPs face challenges including limited biodegradability, high costs, and adverse effects on soil hydrological properties, which can lead to increased water and soil loss. This study examined the potential of lower dosages of biodegradable SAPs to improve the hydrological properties of “Shimajiri-maji” (clay) soil. Three concentrations of biodegradable Fasal Amrit polymer (EFP) (P1: 0, P2: 3 g m−2, and P3: 6 g m−2) were evaluated under three simulated rainfall intensities (I1: 35; I2: 70 and I3: 110 mm h−1) and two gradients (7.5%, and 15%) during consecutive storms. The time to generate runoff, infiltration, runoff, soil loss, and water storage (WS) were quantified over one hour. The results show that runoff generation was delayed in EFP-treated soils compared to the control. Both polymer treatments enhanced infiltration (P2 > P3 > P1) and reduced runoff and soil loss (P2 < P3 < P1). Higher EFP rates improved water storage at surface depths (P3 > P2 > P1). EFP-treated soils exhibited lower interrill erodibility, suggesting greater resistance to soil erosion compared to the control. EFP treatments also significantly improved the soil’s physical properties (bulk density, porosity, organic matter, aggregate stability). EFPs can diminish runoff and soil loss as the EFP-treated plots exhibited greater aggregate stability than the control. It was concluded that low EFP concentrations can improve soil hydrological properties and mitigate soil erosion. Further investigations are needed to optimize the EFP concentrations for different soil types.
Optimizing Nitrogen Input Increased Yield and Efficiency in Maize-Soybean Strip Intercropping System
Authors: Liang Yuwen , Liu Qiannan , Zeng Jinghan , Xiong Fei , Guo Jian , Li Guanghao , Lu Dalei
Published: October 2024

Optimizing nitrogen (N) fertilizer combination is a crucial measure to maximize yield and production efficiency in a maize-soybean strip intercropping system (MSSI). In this field experiment, six maize/soybean N input combinations (0 kg ha−1, F0; 255/30 kg ha−1, F1; 255/45 kg ha−1, F2; 255/60 kg ha−1, F3; 210/45 kg ha−1, F4; 300/45 kg ha−1, F5) were set in 2022 and 2023. The results indicated that optimizing N combination (maize/soybean, 255/45 kg ha−1) could synergistically increase yield and economic benefits. Path analysis results showed that the grain numbers in maize and soybean emerged as the most critical yield-affecting factors. Compared with F0, F5 showed the highest grain yield during the 2-year experiment, and the net return increased by 86.1% (F1), 133.3% (F2), 87.4% (F3), 104.7% (F4), and 128.3% (F5), respectively. Optimizing N input under F2 and F5 notably enhanced the leaf area index (LAI) of maize at the milk stage (R3) and soybean at the full pod stage (R4). Additionally, optimization of N distribution in maize stems at the tassel stage (VT) and soybean leaves at the initial flowering stage (R1) facilitated increased dry matter and N accumulation at the maturity stage, resulting in final land equivalent ratios (LER) of 1.44 and 1.55, respectively. Our results provide a more valuable field N combination for summer maize planting areas (sandy soil areas) in Huang-Huai-Hai and southern China, thus promoting the wider application of MSSI.
Herd-Level Risk Factors Associated with Mycoplasma bovis Serostatus in Youngstock on Irish Dairy Farms
Authors: McCarthy Marie-Claire , O’Grady Luke , McAloon Conor G. , Mee John F.
Published: October 2024

Mycoplasma bovis is a globally significant pathogen of cattle associated with a wide range of clinical syndromes, including respiratory disease, mastitis, arthritis, otitis, and reproductive failure. Since its detection in Ireland in 1994, M. bovis has become a significant contributor to morbidity and mortality in Irish cattle. This study aimed to investigate herd-level risk factors associated with M. bovis seropositivity in replacement dairy heifers, using data from 105 Irish dairy herds. Ten heifers per herd were sampled on three occasions: spring 2018, spring 2019, and autumn 2019. Seropositivity was evaluated using two thresholds: ≥1 positive heifer (Model ≥ 1POS) and ≥3 positive heifers (Model ≥ 3POS). M. bovis seropositivity varied over time, with at least one positive heifer in 50.4% (95% confidence interval (CI): 40.5–60.3) of herds in spring 2018, 35.2% (95% CI: 26.2–45.1) in spring 2019, and 45.7% (95% CI: 36.0–55.7) in autumn 2019. Herds with three or more positive heifers increased from 31.4% (95%CI: 22.7–41.2) in spring 2018 to 42.9% (95% CI: 33.2–52.9) by autumn 2019. Risk factors for M. bovis seropositivity included the purchase of cattle, which significantly raised the odds of seropositivity across multiple visit periods (Model ≥ 1POS: Odds ratio (OR) 3.84, p = 0.02; Model ≥ 3POS: OR 3.69, p = 0.02). Managing more than three land parcels, housing heifer calves separately from bull calves, and sharing airspace between calves and older animals also increased seropositivity risks. Conversely, more colostrum feeds reduced the risk of seropositivity (Model ≥ 1POS: OR 0.81, p = 0.05), while colostrum quality assessment and feeding waste milk showed a trend toward increased risk. These findings suggest the importance of robust biosecurity measures, including limiting cattle purchases, improving calf management, and enhancing colostrum feeding practices, to control the spread of M. bovis. This study provides valuable insights into the epidemiology of M. bovis in Irish dairy herds, emphasising the need for targeted biosecurity and surveillance to safeguard herd productivity.