bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMALISASI FP-GROWTH DENGAN TEKNIK PRUNING UNTUK ANALISIS POLA PEMINJAMAN BUKU UPT PERPUSTAKAAN UNISNU JEPARA
Authors: Manzis Akhmad Hossam , Kusumodestoni R. Hadapiningradja , Mulyo Harminto
Published: February 2025

Dalam era digital, perpustakaan terus beradaptasi untuk menyediakan akses ke informasi dan pengetahuan, mendukung pendidikan dan penelitian, serta melestarikan warisan budaya. Meningkatnya kebutuhan akan bahan bacaan seiring dengan perkembangan teknologi informasi dan literasi digital telah mendorong lonjakan jumlah data yang tersimpan di berbagai platform penyedia informasi termasuk perpustakaan, menjadi semakin banyak. Dengan banyaknya volume data-data tersebut, tantangan dalam pengelolaan, analisis dan penyimpanan menjadi langkah yang makin kompleks. Kurangnya pemahaman preferensi pembaca, ketidakefisienan dalam pengadaan buku, dan kesulitan dalam penentuan tata letak buku menjadi masalah yang timbul dalam manajemen perpustakaan. Maka dari itu analisis data sirkulasi menjadi sangat penting, sebagai contoh menggunakan FP- Growth untuk menemukan pola peminjaman buku. Item - item yang kurang memenuhi kriteria namun tetap disertakan dalam proses penghitungan menyebabkan hasil menjadi kurang signifikan, namun dengan Pruning yang menghapus item dengan frekuensi kemunculan rendah dapat meningkatkan akurasi analisis. Hasil penghitungan FP- Growth mengungkap adanya hubungan antara buku manajemen dan ekonomi dengan support 27%, Confidence 54%, dan Lift 956 yang artinya kedua buku tersebut mempunyai pengaruh yang besar terhadap kemunculan masing- masing. Sedangkan dengan pruning jumlah rule yang dihasilkan semakin sedikit yaitu dari 26 menjadi 8, namun rule memiliki keterkaitan kuat dan nilai yang signifikan.
Child Sexual Abuse Inquiries and the Catholic Church: Reassessing the Evidence
Authors: Miller Virginia
Published: February 2025

This book is an objective, evidence-based analysis of the empirical findings, methodologies and conclusions of the main inquiries into child sexual abuse in the Catholic Church in Europe, the US/Canada, the UK and Australasia. Based on the evidence in these official inquiries it concludes that child sexual abuse in the Catholic Church in these countries, while widespread from 1960-1990 is largely an historical problem; there are relatively few instances of child sexual abuse in the Catholic Church in recent decades. Safe-guarding mechanisms introduced into the Catholic Church since the 1990s have been effective in curbing child sexual abuse. The analysis in this book stands in contrast to sensationalistic, uninformed media reporting on the problem. The book is a second revised and expanded edition, with previously unreleased content.
Post-Fistulotomy Outcomes: A Study of Complications, Healing Time, and Recurrence
Authors: Khan Dr. Tariq Akhtar , Ali Dr. Mohammad , Saha Dr. Krishna Pada , Uddin Dr. Md. Nashir , Khan Dr. Md. Lutful Kabir , Muhsenin Dr. Nunjirul , Nahar Dr. Nazmun , Joarder Dr. Sawantee , Khan Dr. Md. Kuddus Ali
Published: February 2025

Background: Fistulotomy is a widely performed surgical procedure for the management of anal fistulas. While it is considered effective; complications, healing time, and recurrence rates vary. This study aimed to evaluate the outcomes of fistulotomy, focusing on post-operative complications, healing duration, and recurrence rates. Methods: This prospective observational study included 350 patients who underwent fistulotomy across six hospitals in Bangladesh from July 2021 to June 2024. Demographic, clinical, and surgical data were collected using a structured data sheet and outcomes were analyzed. Outcomes assessed included complications (e.g. incontinence, infection, bleeding), wound healing time, recurrence within six months, and patient satisfaction. Results: The majority of patients (84.9%) were male, with a mean age of 39.3 ± 12.1 years. The most common fistula type was intersphincteric (60.9%), and 81.7% were classified as simple fistula. Post-operative complications included temporary flatus incontinence in 7.4%, reactionary hemorrhage in 7% of cases, with no significant infective complications. Cumulative 77.7 % patients experienced complete healing within sixty days, and the recurrence rate was 7.7%. Patient satisfaction was high, with 85.1% of patients expressing satisfaction with the outcomes. The median time for returning to daily activities was 2.3 days, and hospital stays were short (median: 1.2 days). Conclusion: Fistulotomy remains an effective treatment for anal fistulas, with low complication and recurrence rates. Most patients experienced favorable healing times and high satisfaction levels, reaffirming fistulotomy as a reliable surgical approach.
Technical and Hydraulic Studies for the Development of a 5HA Site for Irrigation Purposes in the FADAMA2 Valley (Tahoua-Niger)
Authors: Aboubacar Yerima Bako Djibo , Sani Alou , Yadji Guero , Souleymane Soumana Idrissa
Published: February 2025

This article deals with the technical and hydraulic studies for the development of a 5HA site for irrigation purposes in the FADAMA2 valley, in commune 1 of Tahoua. The objective of this study is to: propose a sustainable development plan for an irrigated area of 5 ha in the said valley in order to improve agricultural productivity and the living conditions of farmers through irrigated production. The methodology adopted consisted of carrying out socio-economic, topographical, hydraulic, hydrological, pedological and environmental studies at this site. The results of the study reveal: (i) the support of the population of Founkoye for this project, (ii) the topographical surveys allowed the determination of the surface area (5 ha), (iii) the determination of the different hydrological parameters, (iv) pedological studies which made it possible to determine the suitability of the soil for irrigated crops. These results contribute to the design and sizing of the development as well as the estimated cost of the work. The summary environmental and social impact study highlighted positive and negative impacts for which mitigation measures are proposed in the environmental and social management plan. The financial analysis is carried out to determine the financial feasibility of this development project.
Investigating the Beliefs towards Traditional Medicine Use and the Effectiveness of Herbal Products for Managing Male Infertility in the Greater Accra Region of Ghana
Authors: N’guessan Benoit B. , Boachie Eugene F. , Atua-Ntow Akosua O. , Wutor Victor C.
Published: February 2025

Background: Male infertility is a significant reproductive health concern affecting millions of couples worldwide. While conventional medical interventions offer viable solutions, an increasing number of individuals are turning towards traditional medicine, specifically herbal products, as an alternative approach to managing male infertility. Methods: The study employed a mixed-methods approach, combining quantitative and qualitative data collection methods. A survey questionnaire was administered to 100 consented adult men with fertility issues to explore their beliefs about traditional medicine and the effectiveness of the herbal products they used. Results: Out of the 100 participants recruited, about 74% preferred herbal products over orthodox medicines to manage infertility. The majority (75%) thought that herbal products were effective in managing male infertility, 41% of them noticed a change in their sperm parameters after using the herbal product of interest, and (33%) thought that the herbal product was responsible for them impregnating their partners. Most respondents (93%) did not experience any side effects after using the herbal products, with only a few of them (7%) reporting side effects. Conclusions: People's beliefs about traditional medicine vary based on their personal experiences and those of others. Based on research findings, herbal products' effectiveness in managing male infertility has shown promising results and should be investigated further.
Detection of Epstein–Barr Virus in Astrocytoma Grade 2 from a Group of Iraqi Patients
Authors: Ali Saad Hasan Mohammed , Mohammed Khalil Ismail A. , Al-Alwany Shakir H. Mohammed , Al-Alwany Amin Abdul Hasan M. , Ali Wifaq M. , AL-Fakhar Suha A. , Mousa Jinan M.
Published: February 2025

Background: Astrocytomas are among the most frequent brain tumors affecting both children and young adults. Objective: To analyze brain tissues with astrocytomas grades II obtained from a group of Iraqi patients for the rate of DNA detection by PCR of oncogenic Epstein- Barr virus. Materials and Methods: (75) brain tissue specimens have been enrolled from patients, which were related to patients; among them 50 patients, aged 20 to 77 years, ( 58 % males and 42% were females) had operations in neurosurgical theatres of Ghazi Al- Hariri Teaching Hospital at The Medical City Complex for astrocytoma (grade 2) and also a number of (25) patients has enrolled, aged 21 to 70 years, (56 % males and 44% were females ), whom brain tissues have histopathological examination shown neither in line of benign brain tumors nor brain cancers, and were including as the control group of the present research work. The current method was performed by using the technique of polymerase chain reaction that was done to amplify and localize of the examined DNA sequence of EBV. Results: 28% (14 out of 50) of the examined brain tissues from astrocytomas grade 2 cases were positive for EBV genome detection. The most infected brain tumor tissues with EBV- DNA are related to the age stratum (20-40 years), which accounted for 14 %, while the age strata of (41-60 years) and (61- 80 years) accounted for 12% and 2 %, respectively. The male patients accounted for 71.4 % while females accounted for 28.6 %, while positive EBV-PCR detection result in brain tissues from control patients without tumors was found in 8% of the examined tissues. Conclusion: high rate of EBV detection in this percentage of the studied astrocytoma grade 2 tissue samples can possibly considered playing in the induction of these brain tumors.
Common Sense Diagrams: The US Two-Party System in Magruder’s American Government, 1917–2023
Authors: Holmén Janne
Published: February 2025

This article investigates how the two-party system is analysed in text and diagrams in US government textbooks. The diagrams are analysed with the help of theories from the cognitive sciences. Magruder’s American Government has dominated the US civics textbook market since its first edition in 1917. That year, the textbook referred to “the four leading parties,” and the two-party system concept first appeared in a diagram in 1930. From 1939, the two-party system was considered a trait of English-speaking countries and was contrasted to the chaotic multiparty systems in Europe, which could end up in dictatorship. From the 1950s, the two-party system was explained as an effect of the electoral system and as a reflection of the lack of divisions in US society. Diagrams of the party system were gradually simplified until the 1990s, when they implied that Democrats and Republicans had unbroken roots in the late 1700s. From the 2010s, more critical explanations of the two-party system appeared, such as that the major parties issue legislation that hinder the formation of new parties.
Ovarian Immature Teratoma Detected During Pregnancy
Authors: Hasdemir Pinar Solmaz , Guvenal Tevfik , Menekse Serkan , Solmaz Ulas , Kandiloglu Ali Rıza , Koyuncu Faik , Ayhan Ali
Published: February 2025

Objective: Malignant ovarian immature teratomas should be considered in differantial diagnosis of adnexal masses detected during pregnancy. This paper is reviewing the clinicopathologic and prognostic characteristics and therapeutic options for treatment of immature teratoma during pregnancy in the context of a case of pregnancy complicated with immature teratoma.
Materials and Methods: A PubMed and Scopus search was conducted with the key words ‘ovarian immature teratoma’ and ‘pregnancy’ and all related published articles assessed. A total of 24 cases, included our case were included in the study. Age at presentation, clinical findings, histologic grades and stages, treatment options and the prognosis of both mothers and fetuses was analysed.
Results: The median age of the patients in the published reports was 27.0± 4.2 ( range 21-36) years. The main presenting symptom was adnexal mass followed by abdominal or pelvic pain. Chemotherapy was added to the surgical treatment in 68.2% of the patients; a Bleomycin, Etoposide and Cisplatin protocol was the preferred treatment option. Prognosis for both mother and fetus were good.
Conclusion: Immature teratoma during pregnancy should be treated immediately with surgery ± chemotherapy especially in high grade patients.
Factors triggering epileptic seizures in patients over 50 years
Authors: Demir Serkan , Togrol Rifat , Sonkaya Ali Rıza , Kendirli Mustafa Tansel , Alay Semih , Celik Tugba Yanar , Delil Sakir , Ozdag Mehmet Fatih
Published: February 2025

Objective:In this study the factors that trigger the seizures in epileptic patients over the age of 50 was investigated and the frequency of seizures was analyzed regarding different age, gender, type of seizure and etiological groups.
Method:  For this purpose, 387 patients were included in the study who were admitted to neurology outpatient clinic with the diagnosis of epilepsy. The patients are divided into groups based on those characteristics: male / female, generalized seizure / partial seizure, age between 50 and 65 / age over 65, they were evaluated in terms of seizure triggers.
Result: The most common precipitating factor in all groups were found as stress (37%), sleeplessness (27%) and forgetting to take the medication (20%). 31% of the patients were on Carbamazepine, 21% were on Levetiracetam and 19% were on Valproic Asid. The most common etiological causes were identified as idiopathic (39%), poststroke(24%) and dementia (15%). Regarding the triggering factor, some statistically significant differences were found between the following groups and control groups; the group with patients between the age 50 and 65: stress, fatigue, waking and sleeping; the group with female patients: sleeplessness; the group with the generalized seizures: alcohol and sleep. 
Conclusion:  In conclusion 68% of our patients complained about at least one seizure precipitant and the most common precipitants were stress, sleeplessness and missing dose of medication. In this study, age between 50 and 65 group is more affected by triggers.
Expert system in medicine and its application on pulmonary diseases
Authors: Bursuk Evren , Demirci Sabriye , Korpinar Mehmet Ali
Published: February 2025

Objective: Our aim is to develop a medical expert system for pulmonary diseases providing practitioners and medical students with the advantages of improving their ability, minimizing the error and cost in diagnosing and developing their medical knowledge.
Material and Methods: CLIPS  has been chosen as a programming environment for this study. A respiratory disease binary decision tree which helps us to create the system database which includes twenty-eight diseases is formed for the inference engine of this program.
Results: The evaluation of this program is based on hundred and eighty-nine patients’ data each is classified into three data types. These are patient’s history and physical findings, radiological data and laboratory data. The combination of them shapes four different data sets for each patient. The diagnosing result for each data set of each patient is compared with diagnosing of gold standards. If both results indicates the same disease this operation of the program is assumed as “accurate”, otherwise as “error”. These operations for the considered each data set are repeated for all patients’ data. The total number of accurate diagnosis is divided by the number of all patients and these accuracy rates are respectively 64.02%, 71.43%, 82.54% and 96.83%.
Conclusion: We can conclude that the accuracy of the system is enhanced with the increasing total number and type of data for each patient. Finally, further improvement on the performance and accuracy of the system may be obtained by designing the program with the self-learning ability.
Relationship between Nurses' Spiritual Well-being and Nurses' perception of competence in providing spiritual care for patients
Authors: Ebrahimi Hossein , Jafarabadi Mohammad Asghari , Arshetnab Hossein Namdar , Khanmiri Soraya Golipoor
Published: February 2025

Objective: As an important factor affecting human's health consequences, spiritual well-being has been the center of attention in recent years. According to literature, nurses' spiritual well-being affects how they provide spiritual care. This paper, thus, aims to find the relationship between nurses' spiritual well-being and their perception of their competence in providing spiritual care for patients in Tabriz Educational-Therapeutic centers
Material and Methods: This is cross sectional-analytical research which is conducted on 555 nurses of medical-educational centers in Tabriz in 2014. Data were gathered using three-part questionnaire including demographic information and Spiritual Care Competence Scale (SCCS) and spiritual well-being scale (SWBS). Data analysis was done using descriptive (frequency, percent, mean, standard deviation) and inferential (independent t, Pearson, Spearman, ANOVA Tukey test) statistics using SPSS 21 software.
Results: Results showed that nurses' spiritual well-being is significantly and directly associated with their perception of spiritual care delivery (P<0.05). Also, Mean score of nurses' perception of their care competence 95.2 (14.4) and Mean score of spiritual well-being 92.4 (12.3) were both above average (P<0.05). Type of employment and experience in participating workshops had significant relationship with the nurses’ perception of their competence for providing spiritual care and spiritual well-being  (P<0.05).
Conclusion: Research findings indicate that nurses' perception of their spiritual well-being and spiritual care competence were above average. There was also a significant and positive correlation between spiritual health and the nurses' perception of their spiritual care competence
Could Computer Game Players React as Quick as Table Tennis Athletes and Perform the Right Action?
Authors: Sahin Senay Koparan , Sagdilek Engin
Published: February 2025

Objective: Table tennis athletes have short reaction times and specialized skills. Computer games may also decrease reaction times. However the actions of the computer game players are limited to mouse/keyboard/joystick use. The objective of the study is to compare the reaction times and the achievement levels on selective action array of athletes and players.
Material and Methods: 10 medical school students that played computer games 10 hours a week for at least 5 years, and 9 table tennis athletes that were trained 10 hours a week for at least 5 years were included in the study. Right/left-hand/foot reaction times against auditory and visual stimuli were recorded for each subject. Selective action array was implemented utilizing a table tennis robot. The robot was set up to send 120 balls in different colors, to different points on the table, in random colors and 90 balls per minute at the same speed. The subjects were asked to ignore the white balls, to touch the yellow balls and to hold the pink balls. The actions that the subjects took, or did not take against each ball were transformed into points.
Results:  It was found that the mean reaction time for athletes was 196.8ms and 196.0ms for the players. The selective action array total points were similar in athletes and players. While the athletes scored better with yellow and pink balls, players scored better with the white balls.
Conclusion: The similar scores and reaction times by players and athletes could be interpreted that it could be beneficial to prioritize visual perception, attention and focusing in selecting athletes and in designing training programs
Why epidural blood patch in postdural pain headache
Authors: Akyol Fethi , Binici Orhan , Kuyrukluyildiz Ufuk , Soyalp Celaleddin , Kupeli Ilke
Published: February 2025

Objective: Spinal anesthesia has some complications such as intravascular injections, nerve injuries, hypotension, bradycardia and dural ruptures. When puncture is performed on dura or araknoid, there is a risk of post-dural-puncture headache.
Material and Methods: 16003 patients, who were operated at the Erzincan State Hospital and Erzincan Mengücek Gazi Education and Research Hospital between 2004 and 2011 were involved in this study. Epidural blood patch was applied on 159 patients complaining of post-dural-puncture headaches. 15 ml of the autologous blood was given to the epidural region in the surgery room for patients which had epidural blood patch applied. Epidural blood patch was applied 2 days after the dural injury
Results: 72 females and 67 males were involved in the study. Symptoms of post-dural-puncture headache disappeared within minutes immediately after the process.  After the first application of epidural blood patch, 156 patients felt relaxed. 3 patients had a relief after the first application, but their symptoms relapsed, and a second injection was performed 24 hours after the first one.  Following the second epidural blood patch,    none of the patients reported any headaches.  No complications emerged during the procedure in the patients. The patients were discharged 2-3 hours after the epidural blood patch application.
Discussion: Epidural blood patch is a treatment method with lower risks of complications, lower costs and high success rate for post-dural-puncture headache patients. It is advised especially after the C-section, for preserving mother-baby communication
Extrude-Sequestrum Spontaneous Regression of Lumbar Disc Hernia: Case Report
Authors: Karabag Hamza , Kilic Mustafa , Ethemoglu Kadri , Iplikcioglu Ahmet
Published: February 2025

The correct approach to the lumbar disc hernia is subject to debate. Although a rare case of lumbar disc herniation with spontaneous regression, to be seen and is a well-known phenomenon commonly reported. But the underlying mechanism has not been fully clarified. Proposed mechanisms are enzymatic degradation and phagocytosis, dehydration and the retraction of a herniated disc in the annulus fibrosus. Cauda equina syndrome, despite the progressive narcotic pain goes outside and progressive neurological deficits, conservative treatment should be given priority to patients. Think about the possibility that spontaneously regressed with medical treatment and follow-up of disc herniation, should not rush to surgery. In our case, the level of lumbar disc herniation was presented on spontaneously regressed patients. The patient's clinical condition is improved in accordance with the resolution of the disc herniation and this is confirmed by magnetic resonance imaging
Triple-X syndrome accompanied by Chilaiditi syndrome in preterm infant: a case report
Authors: Kale Yusuf , Isik Dilek Ulubas , Celik Istemi Han , Bas Ahmet Yagmur , Demirel Nihal
Published: February 2025

Chilaiditi syndrome is a variant of the rotation of the colon that gives rise to the interposition of the colon between the right diaphragm and the liver intermittently or constantly. Also, Necrotizing enterocolitis is typically seen in premature infants.
In this report, we presented a female case report accompanied with a 47,XXX karyotype and Chialiditi syndrome and Necrotizing enterocolitis. This association was not reported in any case study.
Our findings suggest that abnormalities of X chromosome may be associated with other anomalies
Prevalence of Pulmonary Hypertension in Patients with Early Stages of Chronic Renal Disease
Authors: Yenigun Ezgi Coskun , Balli Sevket , Turgut Didem , Gurses Sukran , Ozturk Ramazan , Koc Eyup , Dede Fatih
Published: February 2025

Aim: Pulmonary hypertension (PHT) was recently described as a cardiovascular complication of chronic kidney disease (CKD). There are many studies on the prevalence of PHT in patients undergoing hemodialysis (HD); however, there are no data on the presence or prevalence of PHT in patients with early-stage kidney disease.
Materials and Methods: The demographic and laboratory findings for 172 adult patients with stage 1-5 CKD, as well as Doppler echocardiographic findings were evaluated. Systolic pulmonary arterial pressure (sPAP) was compared according to CKD stage, and also between the patients in stages 1-4 and those in stage 5 with and without AVF.
Results: Mean age of the patients was 55.4 ± 15.2 years. Mean sPAP in the entire study group was 34.5 ± 5.7 mmHg and PHT was noted in 90 (52.3 %) patients. Mean sPAP and the prevalence of PHT were similar in the stage 1-4 patients and stage 5 patients, regardless of HD (P=0.86). The serum calcium level was significantly lower and the serum intact parathyroid hormone level was significantly higher in patients with PHT than in those without PHT (P = 0.02, and P = 0.03).
Conclusion: The present findings show that the prevalence of PHT in patients with early stage CKD was similar to those with stage 5 CKD. Due to the high morbidity and mortality rates associated with PHT, follow-up of sPAP via Doppler echocardiography might be indicated in all patients with CKD.
Assessment of long term patient satisfaction in orthognathic surgery
Authors: Tabakan Ibrahim , Kokacya Omer , Kesiktas Erol , Eser Cengiz , Gencel Eyuphan
Published: February 2025

Objective: Even though there are many reliable data that deal with orthognatic surgery, there is very little information about patient satisfaction. When evaluating the success of the surgery, clinicians usually take postoperative occlusion and cephalometric measurements into consideration. However for the patietns,  aesthetic appearence is as important as occlusion.
Material and Methods: 80 patients who underwent orthognathic surgery between 2003-2011 in Çukurova University were studied. Patients were interviewed either personally or by the phone with a questionairre that reflect patient satisfaction such as preoperative and postoperative  aesthetic facial apperance, change in self confidence, mastication, hypoestesia and pain in temporomandibular joint.
Results: 22,5 % of the patients stated that there was aesthetic improvement, 8,8 % stated only improvement in mastication and 62,5 %  stated there was improvement in both.  A total of 70 %(n=56)  of the patients pointed out there was significant improvement in their self esteem.
Conclusion: This study suggests that outcomes of the surgeries can be evaluated not only by occlusion and cephalometric measurements but also  with subjective complaints and satisfaction of the patients. To achieve long term success in orthognathic surgery, one should know the relationship between function and aesthetic facial appearence and take both of them into consideration equally.
Ecthyma Gangrenosum in a Pediatric Patient and Review of the Literature
Authors: Sarsu Sevgi Buyukbese , Parmaksız Mehmet , Yaman Ayhan
Published: February 2025

Erythema Gangrenosum (EG), is an infective lesion of skin, and mucous membranes typically occurring in patients with chronic disease or immunocompromised patients. İt is a very rarely seen vasculitis with a potentially progressive and fatal course.
An 8-year-old pediatric patient was referred to an external medical center with complaints of fever, abdominal pain, and skin rashes starting 2 days previously, and upon deterioration of his general health state, he was admitted into a surgical intensive care unit with manifestations of septic shock.
In the treatment, all necrotic tissues including skin, and subcutaneous tissue were excised down to a healthy tissue after excision of all necrotic tissue. Vacuum Assisted Closure (VAC) was applied on this area for drainage.
Herein, we aimed to indicate that definitive treatment of a neuropathic child with EG is surgery excision, and also emphasize critical importance of re-excision of newly developed necrotic tissue at an early stage, and close monetarization of the patient.
Plasma adrenomedullin levels in patients with migraine during natural attack and attack free period
Authors: Akcali Aylin , Geyik Sirma , Dogru Ilker , Dogru Arzu , Yurekli Muhittin , Neyal Abdurrahman , Balat Ayse , Neyal Munife Ayse
Published: February 2025

Objective: The role of Calcitonin G related peptide (CGRP) in migraine has been demonsrated. The aim of this study was to examine the role of Adrenomedullin (AM) which is a member of the calcitonin/CGRP/amylin family in migraine patients during naturel attack and attack free period.
Material and Methods: 26 migraine patients (11 with aura, 15 without aura) and 26 healty participants were involved. Blood samples were obtained from each patient in attack and attack free period, then compared with each other and control group.
Results: Mean plasma AM levels were 18.95 pmol/L during migraine attacks, 26.01 pmol/L between attacks, and 33.38 pmol/L in the control group. AM levels of migraine patients were significantly lower than controls during non-attack periods (p=0.001) and more interestingly, it further decreased during attack periods (p=0.001). A comparison of the mean plasma AM levels of migraine with and without aura cases revealed the same statistically significant difference (p=0.00).
Conclusion: The persistently low AM levels in migraine patients gave the impression that in physiological conditions there may be a balance between CGRP and AM and this may be changed towards to the site of CGRP in migraine pathophysiology while causing a decline in AM levels as we had found. Further studies regarding on AM involvement in migraine pathophysiology are needed to confirm these results.
The laparoscopic management of the ureteropelvic junction obstruction: Our initial experience
Authors: Bolat Mustafa Suat , Acikgoz Abdullah , Akdeniz Ekrem
Published: February 2025

Objective:Higher morbidity rates, extensive scar tissue formation and longer hospitalization periods of the standard open surgical methods for ureteropelvic obstruction has led to acceleration of minimal invasive techniques. Success rate and clinical outcomes of laparoscopic pyeloplasty has become comparable with open surgery.
Purpose:The aim was to evaluate the clinical results and complications of transperitoneal laparoscopic pyeloplasty in ureteropelvic obstruction.
Material and Methods:Thirty-three patients with ureteropelvic obstruction were enrolled into this study. Eighteen patients underwent Anderson-Hynes dismembered Pyeloplasty and 15 underwent Y-V plasty. Patients were followed-up at postoperative 3., 6. months and then yearly. Partial or total relief of symptoms  and improvement in diuretic renogram were accepted as success.
Results:Median age was 34.5±15.5(13-74) years, number of males were 13 (39.4%) and females were 20 (60.6%). Median Body Mass Index (BMI) was 25.3±15.4(18.5-33.4). Eight were asymptomatic, and 23 had intermittent pain, preoperatively. Fourteen cases had left ureteropelvic obstruction (42.4%) and 19 had in the right kidney. Intraoperatively 19 cases had aberrant vessel. Mean surgery time was 127.9±38.9 (68-245) minutes, median anastomosis time was 20.8±7.3 (8-39) minutes. Median blood loss was 57.1±28.3 (20-150) mL, median postoperative drainage time was 2.6±1.1 (2-7) days. Only one had prolonged ileus and peritoneal irritation findings. Median narcotic and nonnarcotic requirements were 21.5±4.8 (15-30) and 132.6±37.2 (75-200) mg/day, respectively.  Median follow-up period was 35.1±13.6 (11-59) months. 
Conclusions:Laparoscopic pyeloplasty, is minimally invasive and reliable technique replaces open pyeloplasty in many institutions. Shorter hospitalization, lower postoperative morbidity rates, better cosmetic results and higher success   rates can be easily achieved..
The effect of statin use on lens density as assessed by pentacam hr® lens densitometry in adults
Authors: Cakir Akin , Tokatli Alptug , Kar Taner , Yildirim Yildiray , Duzgun Eyup , Erdal Emrah
Published: February 2025

Objective: To investigate the association between statin use and cataract development by using Pentacam HR Scheimpflug camera system.
Material and Methods: Total 208 age and sex matched participants were included in this prospective, case-control study. 104 long-term statin users as study group and 104 non-statin users as control group constituted to the study. Lens densitometry measurements were performed with the Pentacam HR® (Oculus, Wetzlar, Germany) from three areas (anterior, nuclear, and posterior). These measurements were compared between the groups.
 Results: There were no significant difference at the basic clinical variables (p=0.121, p=0.778). The mean duration of statin use of the study group was 5,4±4,3 years. The mean value of lens densitometry measurement at nuclear area tended to be lower in statin users than controls, but difference was not statistically significant (9.20±1.00 vs 9.35±1.20; p:0.346). However, the mean lens densitometry values at the anterior and posterior areas of statin users were found to be significantly higher than controls (10.44±1.32 vs 9.16±1.09;p<0.001; 7.86±0.49 vs 7.63±0.38; p<0.001,respectively).
Conclusion: The current study finds that long-term statin use seems to be associated with an increased risk of cortical cataracts (anterior-posterior) but not incidence of nuclear cataracts.
An important paraplegia case due to synthetic cannabinoid bonsai abuse
Authors: Demir Serkan , Simsek Hakan , Senol Mehmet Guney , Eroglu Ahmet , Karagoz Ergenekon , Tekeli Hakan , Tugrul Rifat Erdem
Published: February 2025

The number of synthetic derivatives of the world’s most popular and commonly abused drug, cannabis is rapidly growing dayby day. Although the drug has certain applications in the medical field, due to its wide and easy access and cheapness, more people start trying the drug commonly referred to as ‘Bonsai’. This synthetic form of the drug has many different names in different countries. The drug is most commonly referred as “Bonsai” in Turkey, “Spice” in UK and “K2” or “Jamaica” in the US. The synthetic cannabinoids are mainly smoked using a pipe, a hookah (or a bong), or wrapped in cigarette papers. Various cases, including the result of death, have been reported related to ‘Bonsai’ smoking. We present here a case of ‘Bonsai’ drug abuse with unusual presentation of paraplegia.
Pregnancy outcome of a case with Swyer syndrome after bilateral gonadectomy and adjuvant chemotherapy
Authors: Gezer Cenk , Ekin Atalay , Sahingoz Alkim Gulsah , Solmaz Ulas , Karadeniz Tugba , Sayhan Sevil , Ozeren Mehmet
Published: February 2025

Swyer syndrome is a rare disorder characterized by a phenotypic female with an XY karyotype. We presented a patient with Swyer syndrome with a diagnosis of malign germ cell tumor. After bilateral gonadectomy and pelvic lymph node dissection, the patient received four courses of bleomycin, etoposide and cisplatin chemotherapy. The patient was free from tumour recurrence after 13years’ follow-up. A successful pregnancy was achieved by oocyte donation and in vitro fertilization. Caesarean delivery was performed at 37 gestational weeks due to oligohydramnios and intrauterine growth restriction.
Primary small B cell non-Hodgkin Lymphoma of the Lacrimal Sac Upon Chronic Dacryocystitis
Authors: Gumussoy Murat , Uluyol Sinan , Kucuk Ulku , Kurtoglu Gokhan , Kandogan Tolga , Cukurova Ibrahim
Published: February 2025

Primary non-Hodgkin lymphoma of the lacrimal sac is an extremely rare tumor. In this article, we report a 44-year-old female who was referred for dacryocystorhinostomy with complaints of epiphora and swelling on the right lacrimal sac region. She had slight epiphora for 8 years, which increased within 6 months, with concomitant swelling between the eye and the nose.  A hard and fixed mass was detected on palpation just below the medial canthus. Magnetic resonance imaging showed a 30x35 mm tumoral, lesion which invaded the medial wall of the right orbit and compressed the medial rectus muscle.  Histopathologic examination of the tumor revealed a small B cell non-Hodgkin lymphoma. As a conclusion, we suggest that if symptoms of a chronic dacryocystitis patient deteriorates, malignancy should be suspected
Endovascular therapy of isolated internal iliac artery aneurysm
Authors: Ozer Abdullah , Kilic Yigit , Mardin Baris , Akkan Koray , Okkar Levent
Published: February 2025

Isolated internal iliac artery (IIA) aneurysms are relatively uncommon. Isolated IIA aneurysms traditionally have been treated by surgical reconstruction. We report our experience with endovascular treatment of isolated IIA aneurysm.
Major acute pain complications in Congolese children with sickle cell disease
Authors: Ngolet Lydie Ocini , Engoba Moyen , Dokekias Alexis Elira , Innocent Kocko , Moyen George
Published: February 2025

Sickle cell disease is the most frequent genetic blood disorder in the world and pain complications are the most prominent clinical aspects in sickle cell population.
Objectives: Describe the morbidity feature of major acute pain complications in children with sickle cell disease and outcome.
Material and Methods: 166 sickle cell disease children (4.3%) with a mean age of 85.31 months old±60.40 admitted in the pediatric intensive care unit for major acute pain complications were enrolled in the study from January to December 2014. Major acute pain complications were defined as acute sickle cell related pain with an intensity assessed at 3 on the Wong-Baker faces pain rating scale. 
Results:  Over the period study, 118 patients were admitted for diffuse vaso occlusive crisis (70.09%). Localized vaso occlusive crisis occurred in 13.25%, acute chest syndrome in 09.64% and hand foot syndrome in 06. 02%. The most common trigger factors were bacterial infections (65.12%) followed by malaria (34.88%). Mortality of 12.05% was recorded while 27.71% were discharged and 60.24% transferred to other departments. The mortality rate was significantly higher in the range age over 5 years (p=0.004)
Aneurysm of the Internal Carotid Artery Pressing on Dorello’s Canal in a Patient with Bilateral Abducens Nerve Palsy: Case Report
Authors: Cuce Ferhat , Ozgonul Cem , Eroglu Ahmet , Oztimucin Ozgur Bulent , Verim Samet
Published: February 2025

Objective: Abducens nerve palsy (ANP) has an incidence of 11.3/100,000. ANP related to pressure of the aneurysm on the Dorello’s canal is unusual. We report a case of bilateral ANP following head trauma.
Case: A 31-year-old woman was admitted for the evalu­ation of diplopia began after trauma.  In the diagnostic imaging; the magnetic resonance imaging (MRI) revealed the normal course of bilateral abducens nerve (AN) in the pontine cistern. The adjacent anatomy of the right AN from pons up to the oculer bulb was normal.  But the distal part of the left ICA petrous segment at the level of foramen lacerum had a remarkable loss of signal void. Multidetector computed tomography  angiogram demonstrated a left distal petrous ICA aneurysm which was under the Dorello’s canal and remodeling the clivus.
Conclusion: We estimated the left ANP was caused by the pressure of the aneurysm. And the right ANP was probably due to the trauma  the patient had experienced.
A possible alternate pathway for intravascular thrombosis - Investigation of the circumstantial evidence by microfluidics
Authors: Das Siddhartha , Barai Amlan
Published: February 2025

In light of the literature, in this hypothesis, we aimed to settle up an experimental procedure and possible mechanism for bacteremia induced disseminated intravascular coagulation via QA.Bacteremia resulting in sepsis and disseminated intravascular coagulation (DIC) are known for thrombosis and coagulopathy. DIC, which results in simultaneous activation and consumption of coagulation factors, could be investigated using microfluidics as a tool. Here, we propose the hypothesis that bacteria (e.g. E.coli) mediated DIC results from a collective phenomenon called “quorum acting” (QA). If our hypothesis is true, than the coagulation cascade will be activated before systemic inflammation. To check for QA we propose to perform a hemodynamic experiment where blood is controllably flown over E.coli clusters in a microfluidic device. Further, manipulation of the physical properties (flow rate mimicking condition like venous stasis) and chemical properties (hyperglycaemia as in uncontrolled diabetes mellitus) of blood could be done using microfluidic device to mimic their  etiopathogenesis  and to validate our proposed mechanism that quorum acting mediated DIC occurs rapidly in venous stasis and uncontrolled diabetes mellitus respectively.
A novel volumetric analysis using cad/cam scanners in gingival recession treatment
Authors: Aydinyurt Hacer Sahin , Ertugrul Abdullah Seckin
Published: February 2025

Objective: In this study, randomized clinical trial (RCT), the aim was to compare clinical periodontal data of subepithelial connective tissue graft (SCTG) group and SCGT+enamel matrix derivatives (EMD) group in terms of gained gingiva volume (GGV) and gained gingiva surface area (GGSA) by scanners of computer-aided design/computer-aided manufacturing (CAD/CAM) devices.
Material and Methods: In this study, a total of 35 Miller class I-II gingival recession defects were involved (n=17 in SCTG group, n=18 in SCTG+EMD group). In addition to, periodontal clinical parameters, and  three dimensional (3D) images were recorded by using CAD/CAM system before the treatment, at the 1st month and the 6th months after the treatment. The images were superimposed by using softwares and GGV, and GGSA were calculated.
Results: There was no significant difference in terms of GGV and GGSA values at the 1st month and 6thmonths between SCTG+EMD and SCTG groups. Similarly, there was no  significant difference in periodontal clinical parameters between groups.
Conclusion: Images obtained from CAD/CAM system can be easily used in calculating GGV and GGSA data after the gingival recession treatment and in determining of the success of administered treatment. It is expected that the evaluation of the success of many therapeutic approaches for periodontal treatment will be carried out by using CAD/CAM system in the future.
The effects of application of 0.5% levobupivacaine together with 5 mg dexamethasone for infra-clavicular block in surgical treatment of forearm fractures
Authors: Kilic Ertugrul , Karsli Burcin , Evrenos Mustafa Kursat , Erkek Murat , Mizrak Ayse
Published: February 2025

Objective:  We aimed to investigate the effects of adding 5mg dexamethasone to 0.5% levobupivacaine on postoperative analgesia after US-guided infra-clavicular block.
Methods: This prospective study was performed at Sehitkamil Goverment Hospital, Gaziantep, Turkey, between september 2012 and february 2013. Ninty patients presented with fracture of forearm bones. Patients were randomly allocated to receive ultrasound guided infraclavicular brachial plexus blockade using levobupivacaine 0.5% in conjunction with or without dexamethasone 5 mg. In Group I (n=45), 0.9% NaCl was added as adjuvant. In Group II (n=45), 5 mg dexamethasone was added to 0.5% levobupivacaine and surgical anesthesia was provided. Postoperative pain control was provided by using morphine with intravenous patient controlled analgesia (IVPCA). one mg bolus dose was administered, continued with limit of 5 mg/hour and 10 min of locking time. Verbal ranting scala (VRS), patient satisfaction score (PSS) and total morphine consumption were controlled for postoperative 48 hours.
Results: Sensory block onset time was significatly longer in group I. Sensory block time was longer in group II. PSS was higher in group II, total morphine consumption was found more in group I, VRS was significantly higher in group I.
Conclusion: Application of 0.5% levobupivacaine together with 5 mg dexamethasone for infra-clavicular block in surgical treatment of forearm fractures reduces sensory block initiation time, prolongs duration of Sensorial Block and reduces analgesic consumption.
Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome
Authors: Sayiner Zeynel Abidin , Okyar Burak , Eraydin Ayten , Ozkaya Mesut
Published: February 2025

Bartter syndrome  and Gitelman syndrome  are rare autosomal recessive syndromes. In extremely rare cases, GS may diagnosed with growth retardation and diabetes mellitus. In this 3-case series, growth retardation was identified at 17-year follow-up of our dizygotic twin patients diagnosed with BS and glucose metabolism disorder was developed.  Whereas, 3RD. patient diagnosed with GS in adulthood period developed diabetes mellitus after 8 years follow up. Chronic hypopotassemia has been shown to cause diabetes mellitus and growth retardation ın several articles. Potassium plays an important role in insulin, IGF-1 and growth hormone cycle. Herein, we aimed to draw attention to that, the presence of chronic hypopotassemia may precipitate to diseases such as growth retardation and diabetes mellitus over time.
Evaluation of factors that affecting mortality in urgent redo-laparotomies
Authors: Uysal Erdal , Turel Kadir Serkan , Sezgin Efe
Published: February 2025

Objective: The aim of this study was to investigate the factors that affect mortality in patients undergoing Urgent abdominal redo-laparatomies (UARLs) and to analyze the common indications and operative,demograhic and clinical characteristics in UARLs.
Material and Methods: Our study was designed as a retrospective, observational and multi-centric study. A total of 155 patients from two separate clinics undergoing urgent, unplanned redo-laparatomy were included in the study. The data obtained from all clinics were collected and and the relations of the demographic, clinical and operational factors with the mortalities of primary surgery and multiple UARLs were analyzed.
Results: Mortality was observed in 42 (27%) patients. The most frequent causes of mortality were sepsis and multi-system organ failure in 23 (53.4%) patients. The relationships between the number of redo-laparotomy presence of blood transfusion,  older age,classification of surgery  and mortality were significant (p<0.05). 
Conclusion: Sepsis and multi-organ failure were the most frequent cause of mortality in our study as well, with a rate of 53.4 %. No significant relationship was observed between mortality and initial surgery under emergency conditions and presence of comorbidity.  Redolaparatomies inevitable in some clinical situations. Since multiple redolaparatomies are associated with mortality , it is necessary to avoid complications during initial surgery to reduce UARLs. Major surgery operation UARLs in elderly people should be avoided. Finally, the surgeon should also make the UARLs decision at the right time.
Synthesis of Borono Fluoro Deoxy D glucose as Boron carrier for Boron neutron capture therapy (BNCT)
Authors: Akan Zafer , Ozel Taner , Oto Gokhan , Ozdemir Hulya
Published: February 2025

Objective: The 18F-labeled Deoxy-D-Glucose exhibits high affinity to cancer tissue as a PET (Positron Emission Tomography) imaging agent for metastatic cancers. Complexation of 10B to 18F-DG complex may create a useful BNCT (Boron Neutron Capture Therapy) agent for cancer therapy. In previous studies, complexation and characterization of 10B with DG were evaluated and biodistribution analysis was completed successfully. Radioactive tracer labeled 10B-DG will be a useful approach to uses for BNCT applications.
Methods: The 18F-DG synthesized by ion exchange and complexed with 10B(OH)3 via pH reactions. 18F-DG-10B complexation was assayed with Agilent 1260 Infinity HPLC-DAD and Agilent 6420 Triple Quad LC/MS. Complexed molecule defragmented and fragmentation products assayed with Agilent 6420 Triple Quad LC/MS for confirmation.
Results: 10B-18F-DG complex was obtained with ion-exchange pH reaction successfully. Complexation of two 10B(OH)3 to 18F-DG was determined with Triple Quad LC/MS. Purification of 10B-18F-DG is currently in progress.
Conclusions: Radio-labelled 10B-DG will supply new insight to research for BNCT studies. Cancer detection and therapy will be applicable in the same schedule with 10B-18F-DG complex.