bluuebunny/crossref_metadata_2025 huggingface dataset:
Status of Epstein-Barr Virus Coinfection withHelicobacter pyloriin Gastric Cancer
Authors: Singh Shyam , Jha Hem Chandra
Published: March 2017

Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett’s lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells.Helicobacter pyloricauses gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely,H. pyloriand EBV. Approximately 180 per hundred thousand population is developing GC along with many gastric abnormalities. This makes GC the third leading cause of cancer-related death worldwide. Although lots of research are carried out individually for EBV andH. pylori, still there are very few reports available on coinfection of both pathogens. Recent studies suggested that EBV andH. pyloricoinfection increases the occurrence of GC as well as the early age of GC detection comparing to individual infection. The aim of this review is to present status on coinfection of both pathogens and their association with GC.
Aggressive Digital Papillary Adenocarcinoma of the Hand Presenting as a Felon
Authors: Bryant Justin R. , Gardner Preston , Yousif Matthew , Pui John C. , Hajjar Raymond T. , Haass E. Aron
Published: March 2017

Aggressive digital papillary adenocarcinoma is a rare eccrine sweat gland malignancy that is frequently misdiagnosed at initial presentation. Histologically, this tumor is similar in appearance to many adenocarcinomas and as such may be diagnosed as a metastatic lesion. We present the case of a patient with digital papillary adenocarcinoma, which was initially diagnosed as a felon. No consensus has been published regarding the treatment of this disease. A review of the diagnosis, pathology, treatment, and adjunctive treatments of aggressive digital papillary adenocarcinoma are also included.
GWO-LPWSN: Grey Wolf Optimization Algorithm for Node Localization Problem in Wireless Sensor Networks
Authors: Rajakumar R. , Amudhavel J. , Dhavachelvan P. , Vengattaraman T.
Published: March 2017

Seyedali Mirjalili et al. (2014) introduced a completely unique metaheuristic technique particularly grey wolf optimization (GWO). This algorithm mimics the social behavior of grey wolves whereas it follows the leadership hierarchy and attacking strategy. The rising issue in wireless sensor network (WSN) is localization problem. The objective of this problem is to search out the geographical position of unknown nodes with the help of anchor nodes in WSN. In this work, GWO algorithm is incorporated to spot the correct position of unknown nodes, so as to handle the node localization problem. The proposed work is implemented using MATLAB 8.2 whereas nodes are deployed in a random location within the desired network area. The parameters like computation time, percentage of localized node, and minimum localization error measures are utilized to analyse the potency of GWO rule with other variants of metaheuristics algorithms such as particle swarm optimization (PSO) and modified bat algorithm (MBA). The observed results convey that the GWO provides promising results compared to the PSO and MBA in terms of the quick convergence rate and success rate.
Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain
Authors: Jensen Vivi F. H. , Mølck Anne-Marie , Chapman Melissa , Alifrangis Lene , Andersen Lene , Lykkesfeldt Jens , Bøgh Ingrid B.
Published: March 2017

The brain is vulnerable to hypoglycaemia due to a continuous need of energy substrates to meet its high metabolic demands. Studies have shown that severe acute insulin-induced hypoglycaemia results in oxidative stress in the rat brain, when neuroglycopenia cannot be evaded despite increased levels of cerebral glucose transporters. Compensatory measures in the brain during chronic insulin-induced hypoglycaemia are less well understood. The present study investigated how the brain of nondiabetic rats copes with chronic insulin-induced hypoglycaemia for up to eight weeks. Brain level of different substrate transporters and redox homeostasis was evaluated. Hyperinsulinaemia for 8 weeks consistently lowered blood glucose levels by 30–50% (4–6 mM versus 7–9 mM in controls). The animals had increased food consumption, body weights, and hyperleptinaemia. During infusion, protein levels of the brain neuronal glucose transporter were decreased, whereas levels of lipid peroxidation products were unchanged. Discontinued infusion was followed by transient systemic hyperglycaemia and decreased food consumption and body weight. After 4 weeks, plasma levels of lipid peroxidation products were increased, possibly as a consequence of hyperglycaemia-induced oxidative stress. The present data suggests that chronic moderate hyperinsulinaemic hypoglycaemia causes increased body weight and hyperleptinaemia. This is accompanied by decreased neuronal glucose transporter levels, which may be leptin-induced.
Genotyping, Platelet Activation, and Cardiovascular Outcome in Patients after Percutaneous Coronary Intervention: Two Pieces of the Puzzle of Clopidogrel Resistance
Authors: Siasos Gerasimos , Oikonomou Evangelos , Vavuranakis Manolis , Kokkou Eleni , Mourouzis Konstantinos , Tsalamandris Sotiris , Zaromitidou Marina , Kioufis Stamatios , Tsigkou Vasiliki , Deftereos Spyridon , Stefanadis Christodoulos , Tousoulis Dimitris
Published: March 2017

Objectives: Individual platelet responses to antiplatelet therapy depend on genetic, cellular, and clinical factors. CYP2C19 and P2Y12 receptor polymorphisms are implicated in platelet responses to antiplatelet treatment. We aimed to evaluate the impact of CYP2C19 and C34T P2Y12 genotyping on platelet reactivity and cardiovascular outcome in patients after percutaneous coronary intervention (PCI) on clopidogrel treatment. Methods: We enrolled 408 patients with stable coronary artery disease (CAD) receiving aspirin and clopidogrel (75 mg/day) 1 month after PCI. High on-treatment platelet reactivity was evaluated using the VerifyNow Assay in a subset of patients. CYP2C19*2 and C34T P2Y12 genotyping was performed by real-time polymerase chain reaction. The primary end point was the composite of death or hospitalization for cardiovascular causes, and patients were followed for a median time of 13 months. Results: In the total study population, 37% were carriers of at least 1 CYP2C19*2 loss-of-function allele, and 53% were carriers of at least 1 C34T loss-of-function allele. Interestingly, homozygotes of the CYP2C19*2 loss-of-function allele had significantly increased P2Y12 reaction units (PRU) (p = 0.007). However, PRU did not differ between carriers and noncarriers of the C34T loss-of-function allele (p = 0.41). Moreover, carriers of CYP2C19*2 had an increased hazard ratio (HR) for the occurrence of the primary end point (for carriers HR = 1.96, 95% CI 1.05-3.66, p = 0.03), whereas the C34T polymorphism had no impact on the cardiovascular outcome (p = 0.17). Finally, PRU was associated with cardiovascular outcome even after adjustment for the presence of any reduced function allele polymorphism. Conclusions: We documented a different effect of CYP2C19 and P2Y12 receptor polymorphisms on platelet reactivity and cardiovascular outcome in CAD patients after PCI on clopidogrel treatment. Importantly, increased platelet reactivity adversely affects the cardiovascular outcome independently of the studied polymorphisms.
Downregulation of UBAP2L Inhibits the Epithelial-Mesenchymal Transition via SNAIL1 Regulation in Hepatocellular Carcinoma Cells
Authors: Ye Tao , Xu Jing , Du Ling , Mo Wenhui , Liang Yiming , Xia Jinglin
Published: March 2017

Background/Aims: Dysregulation of ubiquitin-associated protein 2-like (UBAP2L) has been reported in tumors, but its role in hepatocellular carcinoma (HCC) progression is unclear. Methods: The expression levels of UBAP2L in HCC tissues and HCC cell lines were detected by western blot and quantitative real-time (qRT) PCR. The effects of UBAP2L expression on HCC cell biological traits, including migration and invasion, were investigated by wound healing assay and matrigel transwell assay. Simultaneously, the expression of epithelial-mesenchymal transition (EMT) markers including E-cadherin, CK-18, N-cadherin, Vimentin, Claudin7 and the promoter activity of E-cadherin were detected by western blot and qRT-PCR. Subsequently, role of SNAIL1 in UBAP2L-mediated EMT and the mechanism underlying UBAP2L-mediated SNAIL1 expression were further investigated. Results: UBAP2L was overexpressed in human HCC tissues compared with peri-tumoral tissues. Downregulation of UBAP2L inhibited migration, invasion and the EMT in highly metastatic HCC cell lines. Furthermore, UBAP2L knockdown inhibited expression of the transcriptional repressor SNAIL1 and its ability to bind to the E-cadherin promoter via SMAD2 signaling pathway, which in turn resulted in increased E-cadherin expression. Additionally, bioinformatics analysis showed that expression of UBAP2L is correlated with poor prognosis in patients with HCC. Conclusions: UBAP2L plays a critical role in maintenance of the metastatic ability of HCC cells via SNAIL1 Regulation and is predictive of a poor clinical outcome.
РОЛЬ МЕДСЕСТРИ В ПРОФІЛАКТИЦІ ТУБЕРКУЛЬОЗУ СЕРЕД БАТЬКІВ ДІТЕЙ ПОЧАТКОВИХ КЛАСІВ
Authors: Perepelytsia A. V.
Published: March 2017

У статті розглянуто актуальну проблему дитячої захворюваності населення України на туберкульоз. Проаналізовано сучасну ситуацію з профілактичних методів туберкульозу в закладах освіти. Акцентовано увагу на необхідності залучення медичної сестри до підвищення рівня знань батьків дітей молодших класів із метою вдосконалення профілактики туберкульозу на етапі попередження та виявлення захворювання.
ОСОБЛИВОСТІ ПІДГОТОВКИ МЕДИЧНИХ СЕСТЕР З ПАЛІАТИВНОЇ ТА ХОСПІСНОЇ ДОПОМОГИ В УКРАЇНІ ТА ПОЛЬЩІ
Authors: Buhaevska N. A. , Reha N. I.
Published: March 2017

Предмет «Паліативна медицина» охоплює засвоєння комплексу медичних, соціальних, психологічних та духовних заходів, спрямованих на поліпшення якості життя пацієнтів, які мають невиліковну хворобу та обмежений прогноз життя, а також членів їхніх сімей. У статті проведено аналіз підготовки магістрів медсестринства. Порівняно особливості викладання паліативної медицини в Україні та Польщі.
TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase–Derived Reactive Oxygen Species Generation in Hypertension
Authors: Ma Ming-Ming , Gao Min , Guo Kai-Min , Wang Mi , Li Xiang-Yu , Zeng Xue-Lin , Sun Lu , Lv Xiao-Fei , Du Yan-Hua , Wang Guan-Lei , Zhou Jia-Guo , Guan Yong-Yuan
Published: March 2017

Ca
2+
-activated Cl
−
channels play a crucial role in various physiological processes. However, the role of TMEM16A in vascular endothelial dysfunction during hypertension is unclear. In this study, we investigated the specific involvement of TMEM16A in regulating endothelial function and blood pressure and the underlying mechanism. Reverse transcription-polymerase chain reaction, Western blotting, coimmunoprecipitation, confocal imaging, patch-clamp recordings, and TMEM16A endothelial-specific transgenic and knockout mice were used. We found that TMEM16A was expressed abundantly and functioned as a Ca
2+
-activated Cl
−
channel in endothelial cells. Angiotensin II induced endothelial dysfunction with an increase in TMEM16A expression. The knockout of endothelial-specific TMEM16A significantly lowered the blood pressure and ameliorated endothelial dysfunction in angiotensin II–induced hypertension, whereas the overexpression of endothelial-specific TMEM16A resulted in the opposite effects. These results were related to the increased reactive oxygen species production, Nox2-containing NADPH oxidase activation, and Nox2 and p22phox protein expression that were facilitated by TMEM16A on angiotensin II–induced hypertensive challenge. Moreover, TMEM16A directly bound with Nox2 and reduced the degradation of Nox2 through the proteasome-dependent degradation pathway. Therefore, TMEM16A is a positive regulator of endothelial reactive oxygen species generation via Nox2-containing NADPH oxidase, which induces endothelial dysfunction and hypertension. Modification of TMEM16A may be a novel therapeutic strategy for endothelial dysfunction–associated diseases.
Aplectana nordestina n. sp. (Nematoda: Cosmocercidae) parasitizing Leposternon polystegum (Squamata: Amphisbaenidae) from Northeastern, Brazil
Authors: AMORIM DARCIANE MARIA DE , SILVA LIDIANE APARECIDA FIRMINO DA , MORAIS DRAUSIO HONORIO , SILVA REINALDO JOSÉ DA , ÁVILA ROBSON WALDEMAR
Published: March 2017

There are currently 760 reptile species known in Brazil, from which about 70 are amphisbaenians with 25 species recorded in the Brazilian northeast (Vanzolini 2002; Gomes & Maciel 2012; Costa & Bérnils, 2014; Roberto et al., 2014). Leposternon polystegum Duméril, is a widespread species distributed in the Amazon, Atlantic Forest, Cerrado, and Caatinga biomes (Porto et al., 2000; Ribeiro et al., 2011). The diet is composed mainly by ants, termites, and coleopteran larvae (Barros-Filho & Valverde, 1996; Gomes et al., 2009).
Two new species of orb-weaving spiders of the genus Larinia (Araneae, Araneidae) in meridional Brazil
Authors: OTT RICARDO , RODRIGUES EVERTON NEI LOPES
Published: March 2017

The araneid genus Larinia Simon currently includes 56 species, eleven of them with New World distribution (World Spider Catalog, 2016). North American species of the genus were revised first time by Levi (1975) and South American species by Harrod et al. (1991). According to these authors there are four species known from subtropical South America (Larinia bivittata Keyserling 1885; L. montecarlo (Levi, 1988); L. t-notata (Tullgren, 1905); L. tucuman Harrod, Levi & Leibensperger, 1991) and also four species known from tropical South America (L. ambo Harrod, Levi & Leibensperger, 1991; L. directa (Hentz, 1847); L. lampa Harrod, Levi & Leibensperger, 1991; L. neblina Harrod, Levi & Leibensperger, 1991). According to Buckup et al. (2010) a total of 209 species of Araneidae are recorded for state of Rio Grande do Sul, including the three species L. bivittata, L. montecarlo and L. t-notata.
New species and records of Omaliini from East Asia (Coleoptera: Staphylinidae: Omaliinae)
Authors: SHAVRIN ALEXEY V.
Published: March 2017

Rove beetles of the tribe Omaliini MacLeay, 1825 (Staphylinidae: Omaliinae) are quite diverse both in terms of morphology and biotopic preferences, they are widespread in all zoogeographic regions of the World (Herman 2001), however they still remain extremely fragmentally studied, and the fauna of the eastern Palearctic is not an exception.
Three new species of the sucking louse genus Hoplopleura (Phthiraptera: Anoplura: Hoplopleuridae) from rodents (Mammalia: Rodentia: Muridae) in northern Australia
Authors: WEAVER HAYLEE J.
Published: March 2017

Three new species of the rodent louse genus Hoplopleura (Anoplura: Hoplopleuridae) are described and illustrated from Australia: H. melomydis new species from Melomys burtoni (Muridae: Hydromyini, grassland melomys) and M. capensis (Muridae: Hydromyini, Cape York melomys) from Queensland; H. notomydis new species and H. setosa new species from Notomys alexis (Muridae: Hydromyini, spinifex hopping mouse) from the Northern Territory. These new louse species are the first lice recorded from each of the three host rodent species.
Revision of the genus Nybelinella (Teleostei, Bythitidae) with a new Atlantic, abyssal species
Authors: NIELSEN JØRGEN G.
Published: March 2017

The genus Nybelinella belongs to the aphyonid clade within the Bythitidae. This mainly abyssal genus is known from 30 specimens. The present revision is based on 24 specimens, of which a scientific examination of four specimens has been published earlier. As a consequence, the generic diagnosis from Nielsen et al. (1999) is here modified. Of the 24 specimens 22 are referred to N. erikssoni (Nybelin, 1957), one to N. brevidorsalis Shcherbachev, 1976 and one to a new species, N. brevianalis n. sp., herein described.
A new leafhopper species of Maiestas Distant (Hemiptera: Cicadellidae: Deltocephalinae: Deltocephalini) from Thailand
Authors: DUAN YANI , DIETRICH CHRISTOPHER H.
Published: March 2017

A new leafhopper species, Maiestas serrata sp.n., is described and illustrated from Thailand. This represents the first record of the genus from Thailand.
DRIHM(2US): An e-Science Environment for Hydrometeorological Research on High-Impact Weather Events
Authors: Parodi Antonio , Kranzlmüller Dieter , Clematis Andrea , Danovaro Emanuele , Galizia Antonella , Garrote Luis , Llasat Maria Carmen , Caumont Olivier , Richard Evelyne , Harpham Quillon , Siccardi Franco , Ferraris Luca , Rebora Nicola , Delogu Fabio , Fiori Elisabetta , Molini Luca , Foufoula-Georgiou Efi , D’Agostino Daniele
Published: March 2017

From 1970 to 2012, about 9,000 high-impact weather events were reported globally, causing the loss of 1.94 million lives and damage of $2.4 trillion (U.S. dollars). The scientific community is called to action to improve the predictive ability of such events and communicate forecasts and associated risks both to affected populations and to those making decisions. At the heart of this challenge lies the ability to have easy access to hydrometeorological data and models and to facilitate the necessary collaboration between meteorologists, hydrologists, and computer science experts to achieve accelerated scientific advances. Two European Union (EU)-funded projects, Distributed Research Infrastructure for Hydro-Meteorology (DRIHM) and DRIHM to United States of America (DRIHM2US), sought to help address this challenge by developing a prototype e-science environment providing advanced end-to-end services (models, datasets, and postprocessing tools), with the aim of paving the way to a step change in how scientists can approach studying these events, with a special focus on flood events in complex topographic areas. This paper describes the motivation and philosophy behind this prototype e-science environment together with certain key components, focusing on hydrometeorological aspects that are then illustrated through actionable research for a critical flash flood event that occurred in October 2014 in Liguria, Italy.
Quantifying the Dependence of Satellite Cloud Retrievals on Instrument Uncertainty
Authors: Shea Yolanda L. , Wielicki Bruce A. , Sun-Mack Sunny , Minnis Patrick
Published: March 2017

Cloud response to Earth’s changing climate is one of the largest sources of uncertainty among global climate model (GCM) projections. Two of the largest sources of uncertainty are the spread in equilibrium climate sensitivity (ECS) and uncertainty in radiative forcing due to uncertainty in the aerosol indirect effect. Satellite instruments with sufficient accuracy and on-orbit stability to detect climate change–scale trends in cloud properties will improve confidence in the understanding of the relationship between observed climate change and cloud property trends, thus providing information to better constrain ECS and radiative forcing. This study applies a climate change uncertainty framework to quantify the impact of measurement uncertainty on trend detection times for cloud fraction, effective temperature, optical thickness, and water cloud effective radius. Although GCMs generally agree that the total cloud feedback is positive, disagreement remains on its magnitude. With the climate uncertainty framework, it is demonstrated how stringent measurement uncertainty requirements for reflected solar and infrared satellite measurements enable improved constraint of SW and LW cloud feedbacks and the ECS by significantly reducing trend uncertainties for cloud fraction, optical thickness, and effective temperature. The authors also demonstrate improved constraint on uncertainty in the aerosol indirect effect by reducing water cloud effective radius trend uncertainty.
Ekman Transport in Balanced Currents with Curvature
Authors: Wenegrat Jacob O. , Thomas Leif N.
Published: March 2017

Ekman transport, the horizontal mass transport associated with a wind stress applied on the ocean surface, is modified by the vorticity of ocean currents, leading to what has been termed the nonlinear Ekman transport. This article extends earlier work on this topic by deriving solutions for the nonlinear Ekman transport valid in currents with curvature, such as a meandering jet or circular vortex, and for flows with the Rossby number approaching unity. Tilting of the horizontal vorticity of the Ekman flow by the balanced currents modifies the ocean response to surface forcing, such that, to leading order, winds parallel to the flow drive an Ekman transport that depends only on the shear vorticity component of the vertical relative vorticity, whereas across-flow winds drive transport dependent on the curvature vorticity. Curvature in the balanced flow field thus leads to an Ekman transport that differs from previous formulations derived under the assumption of straight flows. Notably, the theory also predicts a component of the transport aligned with the surface wind stress, contrary to classic Ekman theory. In the case of the circular vortex, the solutions given here can be used to calculate the vertical velocity to a higher order of accuracy than previous solutions, extending possible applications of the theory to strong balanced flows. The existence of oscillations, and the potential for resonance and instability, in the Ekman flow at a curved jet are also demonstrated.
Comparing Polar Lows in Atmospheric Reanalyses: Arctic System Reanalysis versus ERA-Interim
Authors: Smirnova Julia , Golubkin Pavel
Published: March 2017

Representation of polar lows in the new high-resolution Arctic System Reanalysis (ASR) was for the first time assessed and compared to that in the ERA-Interim. Substantial improvements were found in the 850-hPa relative vorticity and near-surface wind speed information. The latter was found to be in close agreement with satellite-derived estimates. Representation of polar lows from a widely used selective list in ERA-Interim and ASR was estimated as 48% and 89%, respectively. The proportion of polar lows represented in ASR is substantially higher than reported for other reanalyses in previous studies. Verifications were found to be sensitive to the polar low reference list used, and to the definition of a polar low. As found, when a more complete polar low list from a recent satellite-derived climatology was used, the proportion of represented events decreased to 26% and 66% for ERA-Interim and ASR, respectively. Variations in polar low representation in reanalyses were also observed in different regions, with the highest proportion resolved in the Norwegian Sea. Strong dependence between polar low sizes and their representation in ERA-Interim was found. In the case of ASR, polar low representation remains constant in the size range of 200–500 km and slightly decreases only for the smallest systems with diameters less than 200 km. Usage of the strict threshold of 43 K for the atmospheric static stability criterion was found to exclude a considerable number of otherwise well-represented polar lows.
Enteral nutrition increases interstitial brain glucose levels in poor-grade subarachnoid hemorrhage patients
Authors: Kofler Mario , Schiefecker Alois J , Beer Ronny , Gaasch Maxime , Rhomberg Paul , Stover John , Pfausler Bettina , Thomé Claudius , Schmutzhard Erich , Helbok Raimund
Published: March 2017

Low brain tissue glucose levels after acute brain injury are associated with poor outcome. Whether enteral nutrition (EN) reliably increases cerebral glucose levels remains unclear. In this retrospective analysis of prospectively collected observational data, we investigate the effect of EN on brain metabolism in 17 poor-grade subarachnoid hemorrhage (SAH) patients undergoing cerebral microdialysis (CMD) monitoring. CMD-values were obtained hourly. A nutritional intervention was defined as the clinical routine administration of EN without supplemental parenteral nutrition. Sixty-three interventions were analyzed. The mean amount of EN per intervention was 472.4 ± 10.7 kcal. CMD-glucose levels significantly increased from 1.59 ± 0.13 mmol/l at baseline to a maximum of 2.03 ± 0.2 mmol/l after 5 h (p < 0.001), independently of insulin-treatment, baseline serum glucose, baseline brain metabolic distress (CMD-lactate-to-pyruvate-ratio (LPR) > 40) and the microdialysis probe location. The increase in CMD-glucose was directly dependent on the magnitude of increase of serum glucose levels (p = 0.007). No change in CMD-lactate, CMD-pyruvate, CMD-LPR, or CMD-glutamate (p > 0.4) was observed. Routine EN also increased CMD-glucose even if baseline concentrations were critically low ( < 0.7 mmol/l, neuroglucopenia; p < 0.001). These results may have treatment implications regarding glucose management of poor-grade aneurysmal SAH patients.
The science of value: Economic expertise and the valuation of human life in US federal regulatory agencies
Authors: Hood Katherine
Published: March 2017

This article explores efforts to apply economic logic to human life. To do so, it looks at federal regulatory agencies, where government planners and policy makers have spent over a century trying to devise a scientifically sound way to measure the economic value of lives lost or saved by public programs. The methods they have drawn on, however, have changed drastically in the past 40 years, shifting from a ‘human capital’ approach based on models of economic productivity and producing relatively low dollar values to a ‘willingness-to-pay’ approach reflecting consumer choice and producing much higher values. Why, in an era of intense deregulatory pressures, did the valuation model that produced significantly higher estimates – making it easier to justify costly regulation – ultimately win out? This unlikely transition follows a shift in the nature of professional expertise dominating the federal bureaucracy during the 1970s and 1980s, as changing conceptions of health and safety regulation during this period gave academic economists the opportunity to make new claims about the exclusive authority of microeconomic theory for understanding the economic value of life in federal planning. Supporting this argument is a comparative case, the largely unsuccessful attempt to extend the willingness-to-pay model to the valuation of life in the courtroom. Pricing human life thus results not only from the renegotiation of moral boundaries around the economic logic of the market, but also from the reorganization of expert authority and the consolidation of scientific expertise around both the meaning and the measurement of value.
Anterolateral Ligament of the Knee: Anatomy, Function, Imaging, and Treatment
Authors: Patel Ronak M. , Brophy Robert H.
Published: March 2017

The anterolateral ligament (ALL) of the knee has gained attention recently for its potential role in rotational stability of the knee, especially in association with anterior cruciate ligament (ACL) injuries. Anatomic studies have characterized the ALL as it runs in an anteroinferior and oblique direction from the lateral distal femur to the anterolateral proximal tibia, although the prevalence and variance of this ligament are not well understood. Magnetic resonance imaging and ultrasound have identified the ligament and linked it with the classically described Segond fracture. While the ALL likely plays a role in rotational stability of the knee, further studies investigating the significance of ALL injuries and the role of ALL reconstruction in combination with ACL reconstruction are warranted.
The Formation of Spatial and Symbolic Boundaries among Vietnamese Diasporic Skilled Return Migrants in Ho Chi Minh City, Vietnam
Authors: Nguyen-Akbar Mytoan
Published: March 2017

More than 40 years since the end of the Vietnam War, a younger generation of Vietnamese Americans is returning to their parents’ ancestral homeland with career opportunities tied to Vietnam’s economic growth in the past decade. These more permanent return migrations reveal strategies of local and global assertions of belonging and identity management among the “1.5” and second generation of Vietnamese Americans who work in high-skilled professions in their parents’ ancestral homeland. Known there as the Viet Kieu (Overseas Vietnamese), those who work in both corporate and nongovernmental organizations draw upon multiple forms of social and cultural capital to negotiate a third space between the local and global in Westernizing pockets of Ho Chi Minh City, Vietnam. I argue that Viet Kieu constructed symbolic boundaries to distinguish themselves from foreigners and ethno-national boundaries to distinguish themselves from locals, but they also crossed these boundaries to find spaces of belonging in Vietnam. The experiences of this niche subgroup of more skilled Viet Kieu constitute “transnational” instances of active ethnic and national identity renegotiation that reaffirmed the importance of place making and subjective claims to an imagined authentic return experience. This study focused on highly skilled returnees, aiming to analyze how transnational flows of capital such as language, education, and access played into the symbolic boundary making and identity politics of return.
Functional Assessment–Based Interventions for Students With or At-Risk for High-Incidence Disabilities: Field Testing Single-Case Synthesis Methods
Authors: Common Eric Alan , Lane Kathleen Lynne , Pustejovsky James E. , Johnson Austin H. , Johl Liane Elizabeth
Published: March 2017

This systematic review investigated one systematic approach to designing, implementing, and evaluating functional assessment–based interventions (FABI) for use in supporting school-age students with or at-risk for high-incidence disabilities. We field tested several recently developed methods for single-case design syntheses. First, we appraised the quality of individual studies and the overall body of work using Council for Exceptional Children’s standards. Next, we calculated and meta-analyzed within-case and between-case effect sizes. Results indicated that studies were of high methodological quality, with nine studies identified as being methodologically sound and demonstrating positive outcomes across 14 participants. However, insufficient evidence was available to classify the evidence base for FABIs due to small number of participants within (fewer than recommended three) and across (fewer than recommended 20) studies. Nonetheless, average within-case effect sizes were equivalent to increases of 118% between baseline and intervention phases. Finally, potential moderating variables were examined. Limitations and future directions are discussed.
How Strangers Initiate Conversations: Interactions on Public Trains in Germany
Authors: Pütz Ole
Published: March 2017

This article considers how strangers who use public transportation initiate conversations and how disruptions of the transportation system affect interactions among strangers. How conversations are initiated has rarely been discussed in the literature because the majority of research takes the initiation of talk for granted. Building on Goffman, the article tests two hypotheses that explain how strangers initiate conversations. The first hypothesis states that travelers rely on interactional rituals if they have to talk with others because of a rule against opening talk with strangers, a rule that can be relaxed if travelers are faced with disruptive events. The second hypothesis states that a conversation can be initiated without introductory remarks if a traveler’s focus of attention is discernible to another traveler, irrespective of the circumstances travelers find themselves in. I argue that the latter hypothesis better explains how strangers initiate conversations and discuss how this finding may be generalized.
Comorbidity, Polytherapy, and Drug Interactions in a Neurological Context: An Example of a Multidisciplinary Approach to Promote the Rational Use of Drugs
Authors: Busa Giulia , Burlina Alessandro , Damuzzo Vera , Chiumente Marco , Palozzo Angelo C.
Published: March 2017

Purpose:

A high number of adverse drug reactions (ADRs), mainly caused by drug–drug interactions (DDIs), occur in neurological wards and few data are available about incidence and prevalence of DDIs in this context. This study investigated—(1) the prevalence of drug–drug and drug–disease interactions in patients admitted to a neurological unit in Italy, (2) the risk factors for DDIs, and (3) the diseases and the drug classes mostly involved in drug–drug and drug–disease interactions.

Methods:

For 2 months, we performed a retrospective, observational study in the neurological unit of St Bassiano Hospital, enrolling 79 patients who received a drug prescription at discharge.

Results:

About half of the patients were discharged with 5 or more prescribed drugs, and 72% of patients showed potential, clinically relevant DDIs. Linear correlations were observed between age and number of prescribed drugs ( P < .01) and between age and number of interactions ( P < .01). The number of prescribed drugs was associated with the number of detected DDIs ( P < .01). The application of drug interaction alerts and the use of medication inappropriateness criteria (ie, Beers criteria) were not satisfactory in choosing the best therapy for each patient. Therefore, multidisciplinary discussions of each clinical case was required.

Conclusion:

The study demonstrated that the neurological patient, especially if elderly, has a high risk of DDI and ADRs and that many of these can be avoided by case discussion in multidisciplinary team meetings, in which the presence of a dedicated clinical pharmacist is crucial.
Disgust and Anger Relate to Different Aggressive Responses to Moral Violations
Authors: Molho Catherine , Tybur Joshua M. , Güler Ezgi , Balliet Daniel , Hofmann Wilhelm
Published: March 2017

In response to the same moral violation, some people report experiencing anger, and others report feeling disgust. Do differences in emotional responses to moral violations reflect idiosyncratic differences in the communication of outrage, or do they reflect differences in motivational states? Whereas equivalence accounts suggest that anger and disgust are interchangeable expressions of condemnation, sociofunctional accounts suggest that they have distinct antecedents and consequences. We tested these accounts by investigating whether anger and disgust vary depending on the costs imposed by moral violations and whether they differentially correspond with aggressive tendencies. Results across four studies favor a sociofunctional account: When the target of a moral violation shifts from the self to another person, anger decreases, but disgust increases. Whereas anger is associated with high-cost, direct aggression, disgust is associated with less costly indirect aggression. Finally, whether the target of a moral violation is the self or another person influences direct aggression partially via anger and influences indirect aggression partially via disgust.
Proposition of R-phase transformation strip in the phase diagram of Ni-Ti shape memory alloy using electromechanical experiments
Authors: Shayanfard Pejman , Kadkhodaei Mahmoud , Safaee Shahriar
Published: March 2017

The shape memory mechanism associated with R-phase transformation was investigated using electromechanical tests on Ni-Ti shape memory alloy thin wires. To provide a more precise insight into the effects of R-phase on phase transformation of shape memory alloys, wires were prepared in three different initial states prior to conducting the experiments: pure martensite, mixture of R-phase and martensite, and pure R-phase. The electromechanical tests were done in two different loading states (under constant and variable stresses) using specially designed and manufactured apparatuses. Tests under different constant stresses were carried out for three cases of pure martensite, a mixture of martensite and rhombohedral, and pure rhombohedral phase, while those under variable stresses were done on pure martensite as well as mixed martensite and rhombohedral. For all the expressed cases, strain–time responses were investigated during electric heating–cooling cycles to interpret possible microstructural changes in the samples. According to the results, a phase diagram containing R-phase transition strip was proposed for Ni-Ti shape memory alloys.
Mothers’ Decisions to Disclose or Conceal Their Child’s Mental Health Disorder
Authors: Eaton Kim , Ohan Jeneva L. , Stritzke Werner G. K. , Courtauld Hannah M. , Corrigan Patrick W.
Published: March 2017

Parents of children with mental health disorders are often faced with the dilemma of disclosing or concealing their child’s disorder. These decisions have important implications for both child and parent. Our aim is to describe mothers’ experiences with the disclosure dilemma; specifically, we describe what is disclosed (or concealed), how, and why, as well as the consequences of these decisions. Data from interviews with 11 mothers of children (aged 5–13 years) with mental health disorders, and a participatory action research group (four mothers) were thematically analyzed. Mothers selectively disclosed (and concealed) to protect and advocate for their child. Their decisions were often influenced by, or were a reactance to, others’ opinions, with mothers not only avoiding, but also defending against stigma, and exercising their right to privacy. Despite anticipating negative feedback, mothers more often experienced empathy and support following disclosure. Recommendations are made for developing mothers’ confidence in disclosing.
Islamic Influence on HIV Risk and Protection Among Central Asian Male Migrant Workers in Kazakhstan
Authors: Shaw Stacey A. , McCrimmon Tara , Mergenova Gaukhar , Sultangaliyeva Alma , El-Bassel Nabila
Published: March 2017

HIV incidence is increasing in Central Asia, where migrant workers experience risks for acquiring sexually transmitted HIV. As a social and structural factor that may influence perceptions and behavior, we examine how Islam shapes HIV risk and protection. Phenomenological qualitative interviews examine religion and contexts of HIV risk among 48 male Central Asian migrant workers residing in Almaty, Kazakhstan. Men described nonvaginal sex, alcohol use, premarital sex, and extramarital sex as forbidden or frowned upon. Religious networks were unlikely to discuss HIV risks, and some men viewed religious affiliation or practices as protective. Marital practices including neke (religious marriage), polygyny, and bride kidnapping may be linked to risk. Findings suggest adhering to Islamic ideals may be protective for some men, but for others, assumptions of protection may enhance risk. HIV prevention strategies among Central Asian migrants may be strengthened by attention to religious and cultural understandings of risk and protection.
Triggering Innovation Through Mergers and Acquisitions
Authors: Dao Mai Anh , Strobl Andreas , Bauer Florian , Tarba Shlomo Y.
Published: March 2017

In this article, we analyze how shared team and task mental models, developed prior to an acquisition, affect exploration and exploitation activities in the postacquisition phase, and how these effects are dependent on relative size. With a sample of 101 transactions of acquirers from the German-speaking part of Europe, we provide empirical evidence that both shared team and task mental models positively influence exploitation activities following an acquisition, whereby only shared team mental models (TMMs) are beneficial for exploration. We provide empirical evidence that shared mental models in terms of task and team are an important informal source for enhancing exploration and exploitation innovation activities. However, this source of informal coordination is contextual. Although the relationships on exploitation are stable, the beneficial effect of TMMs on exploration is sensitive and devitalized by an increasing relative size. Implications for further research and management practice are given.
Efficacy, Safety, and Timing of 5% Sodium Chloride Compared With 23.4% Sodium Chloride for Osmotic Therapy
Authors: Carter Chris , Human Theresa
Published: March 2017

Background: Bolus doses of 23.4% sodium chloride (NaCl) are commonly used for the treatment of intracranial hypertension; however, delays in administration may occur in patients without central intravenous access. At our institution, equiosmolar bolus doses of 5% NaCl have emerged as potential alternatives to 23.4% NaCl because they may be safely administered through peripheral lines. Objectives: We sought to assess the efficacy in reducing intracranial pressure (ICP), time to administration, and safety of 5% NaCl as compared with 23.4% NaCl for the treatment of intracranial hypertension. Methods: Patients admitted from July 2012 to June 2014 who received boluses of 5% NaCl or 23.4% NaCl for a sustained ICP >20 mm Hg were included. Data collected included measurements of ICP, time to administration, and adverse events. Results: A total of 44 patients were identified; 11 received 5% NaCl, and 33 received 23.4% NaCl. The median percentage reductions in ICP at 30, 60, and 120 minutes in patients who received 5% versus 23.4% NaCl were 34% versus 26% ( P = 0.850), 48% versus 40% ( P = 0.700), and 46% versus 30% ( P = 0.064), respectively. The median time to administration was shorter in the 5% NaCl group (7 vs 11 minutes, P = 0.364). Both groups had a 27% rate of adverse events and no infusion site reactions. Conclusions: These data suggest that 5% NaCl may be as effective as 23.4% NaCl at lowering ICP if given at equiosmolar doses, has a shorter time to administration, and has no difference in the prevalence of adverse events.
Thromboelastrography (TEG) Is Still Relevant in the 21st Century as a Point-of-Care Test for Monitoring Coagulation Status in the Cardiac Surgical Suite
Authors: Hernandez Conte Antonio , Perotti Deena , Farac Lauren
Published: March 2017

Since their introduction into clinical practice in the early 1960s, viscoelastic point-of-care (POC) testing—thromboelastrography (TEG) and thromboelastrometry (ROTEM)—has become increasingly popular in intensive care units, operating rooms, and emergency room settings. As TEG has been an established POC viscoelastic testing modality for many years, there has been more research and analysis of its utility and ability to reduce transfusions in the general, cardiac, and liver surgical sectors compared with ROTEM. The role of TEG versus ROTEM has been greatly disputed, although both continue to be utilized in the cardiac suite to guide transfusion in cardiac surgery as these procedures produce a profoundly different form of bleeding compared to other surgical interventions.
Cognitive impairment in pediatric-onset multiple sclerosis is detected by the Brief International Cognitive Assessment for Multiple Sclerosis and computerized cognitive testing
Authors: Charvet Leigh E , Shaw Michael , Frontario Ariana , Langdon Dawn , Krupp Lauren B
Published: March 2017

Background:

Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible.

Objectives:

The goal of this study was to measure the sensitivity of two cognitive assessment approaches that are brief, repeatable, and suitable for clinical practice and for multicenter investigation.

Methods:

Participants with POMS ( n = 69) were consecutively evaluated as part of outpatient neurologic visits and compared to healthy control participants (HC, n = 66) using the Brief International Cognitive Assessment for MS (BICAMS) approach and timed information processing measures from Cogstate, a computer-based assessment.

Results:

There was strong agreement in the detection rate of impairment between both assessments, with 26% for the BICAMS and 27% for Cogstate. Two of the Cogstate tasks were the most sensitive individual measures.

Conclusion:

Both the BICAMS and Cogstate timed processing measures offer practical, sensitive, and standardized approaches for cognitive screening assessment in POMS.
Choreography, controversy and child sex abuse: Theoretical reflections on a cultural criminological analysis of dance in a pop music video
Authors: Dearey Melissa
Published: March 2017

This article was inspired by the controversy over claims of ‘pedophilia!!!!’ undertones and the ‘triggering’ of memories of childhood sexual abuse in some viewers by the dance performance featured in the music video for Sia’s ‘Elastic Heart’ (2015). The case is presented for acknowledging the hidden and/or overlooked presence of dance in social scientific theory and cultural studies and how these can enhance and advance cultural criminological research. Examples of how these insights have been used within other disciplinary frameworks to analyse and address child sex crime and sexual trauma are provided, and the argument is made that popular cultural texts such as dance in pop music videos should be regarded as significant in analysing and tracing public perceptions and epistemologies of crimes such as child sex abuse.
An approach to quantify the influence of ground motion uncertainty on elastoplastic system acceleration in incremental dynamic analysis
Authors: Deng Peng , Pei Shiling , van de Lindt John W. , Liu Hongyan , Zhang Chao
Published: March 2017

Inclusion of ground motion–induced uncertainty in structural response evaluation is an essential component for performance-based earthquake engineering. In current practice, ground motion uncertainty is often represented in performance-based earthquake engineering analysis empirically through the use of one or more ground motion suites. How to quantitatively characterize ground motion–induced structural response uncertainty propagation at different seismic hazard levels has not been thoroughly studied to date. In this study, a procedure to quantify the influence of ground motion uncertainty on elastoplastic single-degree-of-freedom acceleration responses in an incremental dynamic analysis is proposed. By modeling the shape of the incremental dynamic analysis curves, the formula to calculate uncertainty in maximum acceleration responses of linear systems and elastoplastic single-degree-of-freedom systems is constructed. This closed-form calculation provided a quantitative way to establish statistical equivalency for different ground motion suites with regard to acceleration response in these simple systems. This equivalence was validated through a numerical experiment, in which an equivalent ground motion suite for an existing ground motion suite was constructed and shown to yield statistically similar acceleration responses to that of the existing ground motion suite at all intensity levels.
Normalizing in student counseling: Counselors’ responses to students’ problem descriptions
Authors: Svinhufvud Kimmo , Voutilainen Liisa , Weiste Elina
Published: March 2017

University students seek counseling to discuss concerns about their academic skills, motivation, time management and well-being. This article examines the conversational activity of normalizing recurrently used by counselors to manage students’ negative emotions and troubles-telling. Normalizing refers to an activity in which something in the interaction is made normal by labeling it ‘normal’ or ‘commonplace’ or by interpreting it in an ordinary way. Three uses for normalizing were identified in a sample of 16 videotaped counseling sessions: (1) supporting the student’s position, (2) challenging the student and (3) presenting the student’s problem as workable. We argue that normalizing is a means of addressing students’ problematic emotions and offering support, yet in a way that maintains an orientation toward problem solving. Furthermore, while normalizing seems to serve affiliation, suggesting that the problems are not unique, it can be treated either as delicate or as problematic by the counselors and by the students.