bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide Analysis of the bHLH Transcription Factor Family and Functional Identification of bHLH Genes Related to Puerarin Biosynthesis in Pueraria lobata var. thomsonii (Benth.)
Authors: Xiao Liang , Huang Ding , Wu Zhengdan , Shang Xiaohong , Cao Sheng , Zeng Wendan , Lu Liuying , Shi Pingli , Yan Huabing
Published: June 2022

Plant basic helix-loop-helix (bHLH) transcription factors are involved in diverse biological process. Several bHLH transcription factors have been functionally characterized in various crop species. However, no systematic and comprehensively identification of bHLH members has been in Pueraria lobata var. thomsonii (Benth.) (P. thomsonii), a traditional Chinese herb that is an excellent source of puerarin. Phylogenetic analysis showed that 219 bHLH genes were identified in the P. thomsonii and classified into 13 subfamilies. All the PlbHLH genes were distributed on the 11 chromosomes unevenly and the number of PlbHLH genes on each chromosome varied from 12 to 44. Both of tandem and segmental duplications were key factors driving bHLH gene family expansion in P. thomsonii. The gene structure analysis indicated that 20 conserved motifs were found in PlbHLH gene family, 185 PlbHLH members contain more than two introns, and genes within the same subfamily appeared to share similar intron-exon gene structures. The Ka/Ks analysis indicated PlbHLH gene family undergo purifying selection during evolution. The hierarchical clustering analysis indicated that 41 PlbHLHs showed root-specific expression patterns, and seven of them exhibited up-regulated expression pattern after MeJA treatment within 24 h. Using qRT-PCR validation, five puarian synthesis genes had a similar expression pattern with the seven PlbHLH genes in response to MeJA within 24 h. Together, our study provided a good foundation for further research into the regulatory mechanism of the seven candidate PlbHLH proteins for pueraria biosynthesis in P. thomsonii.
Public Awareness on Biodiversity Conservation and Well-Being: Case of Gunung Mulu National Park, Sarawak
Authors: Ibrahim Mohamad Syahrul Nizam , Assim Mohd Ibrani Shahrimin Adam , Johari Shazali , Mohammad Syarifah Kamariah Wan , Afandi Syamsul Herman Mohammad , Hassan Suziana
Published: June 2022

Lack of public awareness of biodiversity conservation is the leading cause of biodiversity loss. This needs to be emphasized by stakeholders in the conservation effort, particularly in some major conservation areas, including the UNESCO World Heritage sites of Gunung Mulu National Park (GMNP). As a result of threats such as natural catastrophes, pollution, poaching, and uncontrolled urbanization or human development, GMNP is at risk of being inscribed on the List of World Heritage in Danger. The UNESCO status is possible to be drawn if its criteria are not maintained or degraded due to a lack of emphasis on awareness of the importance of the site. However, it is still limited information on to what extent is the public aware of the importance of biodiversity conservation in GMNP and its relationship to their well-being. Thus, the study aims to examine the level of awareness (knowledge, attitude, and experience) among local community and visitors in GMNP towards biodiversity conservation; and determine their well-being, specifically on environmental, economic, and social factors concerning conservation awareness. A validated questionnaire was distributed to the visitors (n=87) and local community (n=99) through an online and face-to-face survey. Based on the awareness constructs, their level of knowledge and experience is high, while attitude portrays a moderate level. The visitors have a higher level of knowledge, attitude, and experience than the local community. The level of education and number of dependents had influenced their awareness of conservation. In terms of well-being, the economic and social factors had significantly predicted awareness accordingly. It shows that the dimensions of the neighborhood, life and social relations, services and facilities, education, culture, and monthly income influence their current level of awareness of biodiversity conservation. The empirical study provides insights into developing a biodiversity conservation framework for GMNP that emphasizes community psychology as part of the social movement toward holistic management in the park.
Characterization of briquettes developed from banana peels, pineapple peels and water hyacinth
Authors: Mibulo Tadeo , Nsubuga Denis , Kabenge Isa , Wydra Kerstin D.
Published: June 2022

Background: Uganda's energy needs are heavily reliant on biomass sources. This dependency of Uganda's burgeoning population on biomass for household and commercial purposes is posing pressure on natural resources such as forests. This study was carried out to investigate the utilization of some of the country's highly produced agricultural waste for the creation of biofuels.Methods: Pineapple peels, banana peels and water hyacinth were utilized for generation of both carbonized and uncarbonized briquettes. Physical properties and calorific values for the developed briquettes were determined through thermogravimetric analysis and using a bomb calorimeter.Results and conclusion: Pineapple peel carbonized briquettes had the highest calorific value (25.08 MJ/kg) followed by a composite of banana peels and pineapple peels (22.77 MJ/kg). The moisture content for briquettes ranged between 3.9 to 18.65%. Uncarbonized briquettes had higher volatile matter (ranging between 62.83 and 75.1%) than carbonized briquettes (ranging between 22.01 and 24.74%). Uncarbonized briquettes had shorter boiling time (ranging between 27 and 36 minutes for 2.5 liters) than carbonized briquettes (ranging between 26 and 41 minutes). Water hyacinth alone produced briquettes with low calorific values (16.22 MJ/kg), however, calorific values increased when mixed with banana (20.79 MJ/kg) or pineapple peels (20.55 MJ/kg). The findings reveal crucial information on how agricultural wastes might be used to augment the energy sources pool in order to protect the environment and creating social stability in the community.
Neurobiological substrates of chronic low back pain (CLBP): A brain [99mTc]Tc-ECD SPECT/CT study
Authors: Wichert-Ana Lauro , Lia Erica Negrini , Papassidero Priscila Colavite , Coelho Eduardo Barbosa , Dach Fabíola , Alexandre-Santos Leonardo , Trevisan Ana Carolina , Santos Lucas Emmanuel Lopes e , Silvah Jose Henrique , Lanchote Vera Lúcia , Pasqua Oscar Della
Published: June 2022

Recent neuroimaging studies have demonstrated pathological mechanisms related to cerebral neuroplasticity in chronic low back pain (CLBP). Few studies have compared cerebral changes between patients with and without pain in the absence of an experimentally induced stimulus. We investigated the neurobiological substrates associated with chronic low back pain using [99mTc]Tc-ECD brain SPECT and correlated rCBF findings with the numeric rating scale (NRS) of pain and douleur neuropathique en 4 questions (DN4). Ten healthy control volunteers and fourteen patients with neuropathic CLBP due to lumbar disc herniation underwent cerebral SPECT scans. A quantitative comparison of rCBF findings between patients and controls was made using the Statistical Parametric Mapping (SPM), revealing clusters of voxels with a significant increase or decrease of rCBF. The intensity of CLBP was assessed by NRS and by DN4. The results demonstrated rCBF increase in clusters A (occipital and posterior cingulate cortex) and B (right frontal) and decrease in cluster C (superior parietal lobe and middle cingulate cortex). NRS scores were inversely and moderately correlated with the intensity of rCBF increase in cluster B, but not to rCBF changes in clusters A and C. DN4 scores did not correlate with rCBF changes in all three clusters. Perspective: This study will be important for future therapeutic studies that aims to validate the association of rCBF findings with the pharmacokinetic and pharmacodynamic profiles of therapeutic challenges in pain.
Analysis of Determinants of Groundwater Depletion in Punjab: A Case of India
Authors: Bhardwaj Mandeep , Dutta Tanima , Singh Japal
Published: June 2022

Agriculture is the lifeline for many economies, India being one of them. Many issues have arisen because of intense agriculture adopted in India, especially since nineties. Groundwater depletion is one of the burning issue plaguing Indian agriculture. Punjab, our study area is flagged as over-exploited area since the nineties. This study focuses on identifying the determinants of poor groundwater condition in Punjab from 1996 to 2018. The methodology used to establish the relationship between various agriculture related variables and groundwater depletion is Feasible Generalised Least Square model as OLS has inherent problems when it deals with panel data. The study has shown a positive significant effect of changing cropping intensity, well density, irrigation through tube-well, and technology (tractor) on depletion of groundwater. However, change in area under paddy has shown a negative effect on groundwater depletion due to the Preservation of Subsoil Water Act, 2009. So, it implies Government must have to find out alternatives way of reducing the intensive use of groundwater and need to reframe its agriculture policies.
Palm oil-containing high-fat diet with LPS and CCl4 C57BL/6J mouse model induces the progression of NASH/liver fibrosis and remodels the gut microbiota and its function
Authors: Panyod Suraphan , Wu Wei-Kai , Hsieh Ya-Chi , Tseng Yea-Jing , Peng Sin-Yi , Chen Rou-An , Huang Huai-Syuan , Chen Yi-Hsun , Shen Ting-Chin David , Ho Chi-Tang , Liu Chun-Jen , Chuang Hsiao-Li , Huang Chi-Chang , Wu Ming-Shiang , Sheen Lee-Yan
Published: June 2022

Animal models of non-alcoholic steatohepatitis (NASH) and liver fibrosis are essential for preclinical research of novel drugs. A high-fat diet (HFD) animal model has an indispensable role in the research of gut-liver axis by generating an imbalance of gut microbiota and intestinal leakage, resulting in translocation of harmful bacterial metabolites and lipopolysaccharides (LPSs) to the liver, triggering hepatic immune responses, and stimulating NASH and liver fibrosis. Replacing trans-fat with palm oil in HFDs is an emerging animal model with human translatability in terms of liver biopsy phenotype and transcriptome changes. We developed the NASH and fibrosis C57BL/6J mouse model using a palm oil-containing high-fat diet (P-HFD) combined with LPS to simulate gut dysbiosis and endotoxemia and examined the role of carbon tetrachloride (CCl4) on the gut-liver axis. We developed the mouse models, and the mice were fed P-HFD with or without intraperitoneal LPS/CCl4 injections. NASH/fibrosis progression and gut microbiota shift were examined at 4, 8, 12, 16, 20, and 24 weeks (n=192). The animal model showed obesogenic and metabolic changes, hepatomegaly, increased hepatic lipid levels, NASH phenotype, increased gut dysbiosis, changes in gut microbiota and its function, reduced beneficial bacteria, increased pathogenic related microbiome, intestinal leakage, and endotoxemia. P-HFD with LPS supplementation resulted in comparable NASH, intestinal leakage, and endotoxemia phenotypes compared with the P-HFD group, but worsened the degree of intestinal microbiota dysbiosis by increasing the occurrence of pathogenic bacteria and reducing beneficial microbiota. P-HFD with CCl4 resulted in a liver fibrosis phenotype and produced a more severe gut microbiota shift. These mouse models could be informative for a researcher focused on the gut-liver axis and could be used as valuable tool for preclinical drug testing.
Pan-cancer profiles of cuproptosis gene set regarding the potential values of diagnosis, prognosis, immune therapy, and drug therapy prediction
Authors: Liu Hengrui , Tang Tao
Published: June 2022

Background
A recent paper has revealed a novel cell death pathway, the cuproptosis, a programmed cell death based on copper. This study aimed to evaluate the pan-cancer genomics and clinical association of four pro-cuproptosis genes SLC31A1, FDX1, DLAT, and LIAS, and an anti-cuproptosis gene ATP7B.
Methods
By mining multi-omic profiling data, we performed a comprehensive and systematic characterization of cuproptosis genes across more than 9000 samples of 33 types of cancer.
Results
ATP7B was the most mutated gene. UCEC and SKCM had the most cuproptosis gene mutation while the mutation of LIAS was associated with worse survival of BRCA. Brain cancer and lung cancer were found to potentially have a higher cuproptosis compared to normal tissues because their anti-cuproptosis gene ATP7B was downregulated with the pro-cuproptosis genes overexpressed in cancer tissues. On the contrary, KIRC was found to potentially have a lower cuproptosis. The cancer-non-cancer expression patterns were confirmed at the protein level for lung cancer and kidney cancer. The cuproptosis gene expression was associated with the survival of LGG, KIRC, and ACC. Half of the cancer types showed correlations between copy number variation and expression for these cuproptosis genes. The copy number variations of KIRC, UCEC, and ACC were associated with survival. The expression of DLAT, LIAS, and ATP7B were negatively correlated with the methylation in most of the cancer types. The cuproptosis miRNA and pathway regulation networks were constructed. The cuproptosis genes were correlated with immune cell infiltration levels of multiple immune cells. The cuproptosis signature performed better in the prediction of immune therapy than MSI. score, TMB, T.Clonality, and B. Clonality and might potentially associate with the survival of immune therapy patients in SKCM and KIRC. These cuproptosis genes were correlated with the sensitivity of cancer cells to multiple drugs.
Conclusion
Cuproptosis might play a role in brain cancer, lung cancer, and kidney cancer with potential values of diagnosis, prognosis, immune therapy, and drug therapy prediction.
Pan-cancer profiles of the cuproptosis gene set
Authors: Liu Hengrui
Published: June 2022

A recent study has revealed a novel cell death pathway, called “cuproptosis”, a programmed cell death based on copper. A total of 12 genes were involved in the cuproptosis pathway, including 7 pro- cuproptosis genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB) genes, 3 anti-cuproptosis genes (MTF1, GLS, and CDKN2A), and 2 key copper transporters ATP7B and SLC31A1. The insight into these cuproptosis genes in cancer is necessary to understand cuproptosis-related tumorigenesis and to develop the cuproptosis pathway as a potential therapeutic target for clinical cancer treatment. By mining multi-omic profiling data, we performed a comprehensive and systematic characterization of the cuproptosis of these 12 genes across more than 9000 samples of 33 types of cancer. This letter not only revealed diverse mechanisms of the gene expression regulations of the cuproptosis gene set in cancer but also analyzed the potential associations between cuproptosis and other common cancer pathways, providing an overall picture of cuproptosis in cancer for future reference. This study comprehensively clarified the genomic pan-cancer profiles of the cuproptosis gene set regarding the SNV, CNV, methylation, mRNA expression, pathway cross-talk, and miRNA regulations across 33 solid tumors. Our findings revealed that genomic alterations and miRNA-mRNA network-mediated ectopic expression of cuproptosis genes were involved in the activation of other cancer-related pathways and also identified KIRC as a potential cancer type that might be affected by cuproptosis. We think, as the rase of the cuproptosis cancer research, these in-time profiles will provide a genetic overview and useful information for future studies on the cuproptosis in cancers.
BeRSTID: A Behaviour Real-Time Spatial Tracking Identification System used for Cat Behaviour Monitoring in an Animal Shelter
Authors: Eagan Bailey , Eagan Ben , Protopopova Alexandra
Published: June 2022

The ability to efficiently track animal behaviour in an animal shelter has direct lifesaving applications. However, monitoring behaviour is a challenge as time and financial resources are often limited, and the size and needs of animal populations within shelters are commonly in flux. Individualized care and early recognition of distress in cats are often missed. Our research required a method of behavioural observation that was simple, accessible, used limited human and computer resources and allowed for real-time feedback. Here, we present BeRSTID, an open-source behaviour real-time spatial tracking identification system demonstrated on six cats in an animal shelter using unique 2D fiducial markers. The markers were attached to custom veterinary paper identification collars for feedback on individual animal behaviour over time. Our findings show BeRSTID correlated closely to human-coded data in both real-time and post-event processing modes of eating and drinking behaviours of cats in naturalistic shelter environments. By building upon a lateral concept of marker tracking for direct applied use in a new context, we present a low-barrier user-friendly solution using common technologies that can track and help improve welfare in animal care facilities such as shelters. Further extensions of BeRSTID can be generalized to track unique subjects in a range of environments for multiple use cases.
Modelagem de previsão de acúmulo de água pluvial para reserva técnica de incêndio pela utilização de bases de dados de sensoriamento remoto por satélite
Authors: Nascimento Marcos Guedes do , Menezes Júnior Raimundo Aprígio de , Souza Bruno César Bezerra Nóbrega de
Published: June 2022

A captação de água pluvial tem sido adotada para reduzir o consumo de água potável. Sob esta ótica, o presente trabalho busca analisar o acúmulo de água pluvial para Reserva Técnica de Incêndio do prédio do PRODEMA, localizado nas dependências da Universidade Federal da Paraíba, João Pessoa, Brasil. Para realização do estudo, foram utilizadas informações pluviométricas relativas a 15 pontos da cidade, de 2015 a 2020, adquiridas nas bases de dados dos produtos de sensoriamento remoto por satélite PFLDAS, PGLDAS e TERRACLIMATE, pela emprego da ferramenta computacional de nuvem Google Earth Engine. Como resultados, verificou-se que a PFLDAS e a TERRACLIMATE apresentaram valores em patamares próximos, enquanto que a PGLDAS traz valores inferiores aos destas bases. No período de março a agosto, a pluviosidade mostrou-se alta, com variações entre 250 e 350 mm, enquanto que, de setembro a dezembro, ocorreram as menores pluviosidades, com médias entre 20 e 30 mm. Ficaram nítidas as discrepâncias entre os dados das bases, principalmente em razão dos valores destoantes da PGLDAS em relação às demais. Contudo, isto não compromete os resultados, pois a utilização de precipitações médias, a partir de informações das três bases, mitigam de maneira aceitável tais divergências. Os volumes médios anuais acumuláveis na edificação considerada, podem chegar a 927 m3 em anos menos chuvosos e a 1.390 m3 nos anos de maior incidência de chuva. Sendo assim, para um sistema de hidrantes tipo 1, com RTI de 5 m3 e para um sistema de hidrantes tipo 2, cuja RTI seja 10 m3, será possível abastecê-lo em, no máximo, 2 a 4 dias, a depender do sistema de hidrante utilizado. Mesmo num mês seco, em que o volume médio acumulado diariamente é de 0,5 m³, a RTI será totalmente atendida entre 10 e 20 dias. Deste modo, ficou evidenciado que a RTI pode ser devidamente suprida pela água da chuva, desde que se garanta a manutenção permanentemente do seu nível. Sugere-se para isto, que o reservatório seja elevado e que extravase a água excedente a um reservatório maior, localizado no solo e conectado permanentemente a ele. A partir daí, deve-se avalizar que, caso a RTI seja total ou parcialmente esvaziada, haja reabastecimento imediato com a água do segundo reservatório, por meio de bombeamento hidráulico.
Uso da inteligência artificial na análise de processos como instrumento de eficiência: um estudo de caso à luz da sustentabilidade
Authors: Alheiros Dilma Maria Guerra Brandão , Sousa Wanderson dos Santos , Cordeiro Luiz Filipe Alves , Silva Martorelli Dantas da
Published: June 2022

O número de demandas que chega ao Poder Judiciário transformou-se em alerta para que se buscassem mecanismos para a consecução de uma Justiça célere e econômica. A tecnologia da informação, via inteligência artificial (IA), apresenta um método extraordinário para um caminho transformador dessa realidade. O objetivo deste trabalho se propõe a analisar e responder ao problema de pesquisa: o uso da inteligência artificial pode contribuir para o desenvolvimento de soluções, com vistas ao aprimoramento para o Poder Judiciário Pernambucano. A metodologia inicia-se com um breve histórico da reformulação do modelo de gestão no judiciário, delimitando linhas gerais do executivo fiscal, passando pela introdução do processo eletrônico, e chegando ao ponto central da questão, com o estudo da inteligência artificial aplicado ao processo judicial e sua repercussão. Os resultados demonstram a importância do Sistema ELIS, baseado em inteligência artificial, para a eficiência do Poder Judiciário. Modernizar o Poder Judiciário significa racionalizar os trabalhos simplificando as rotinas procedimentais nas Varas dos Executivos Fiscais Municipais, com o propósito de alcançar a máxima eficiência operacional, sendo a tecnologia uma ferramenta indispensável nesse processo.
Análise crítica da gestão municipal de resíduos sólidos urbanos na Região Amazônica Brasileira: o caso do Município de Tonantins
Authors: Cunha Karen Clara Leão da , Nagalli André , Soares Junior Amazonino
Published: June 2022

A região amazônica brasileira é conhecida mundialmente por sua vasta floresta tropical e por abrigar uma das maiores biodiversidades do planeta. A região vem passando por intensas transformações, ligadas principalmente a falta de saneamento básico. O presente trabalho tem como objetivo analisar criticamente o sistema de gestão de resíduos sólidos urbanos no Município de Tonantins, Estado do Amazonas. Este foi analisado pela comparação entre os objetivos e diretrizes da Política Nacional de Resíduos Sólidos e o atual modelo de gestão adotado pelo município. Os procedimentos metodológicos consistiram em pesquisa bibliográfica, visitas in loco, entrevistas e registros fotográficos. Tonantins não oferta coletores de resíduos em locais públicos, não há segregação de resíduos na fonte por sua população, não há estabelecidos dias específicos para a coleta de resíduos, chegando estes a ficar acumulados nas calçadas por até quinze dias, e o destino dos resíduos coletados é inadequado, são dois lixões. Por fim, pode-se concluir que Tonantins apresenta um processo de gerenciamento de resíduos deficiente e ineficiente, não estruturado na forma de um sistema de gestão, e que o atual modelo de gestão não dá atendimento ao que preconiza a legislação brasileira, necessitando de políticas públicas urgentes para solução desta questão.
Evaluation of magnesium chloride waste recovery: A case study in nanofertilizers
Authors: Prates Patrícia Bodanese , Moraes Elisângela Guzi de , Cesconeto Francielly Roussenq , Vicente Francisco Alves , Boca Santa Rozineide Aparecida Antunes , Schabbach Luciana Maccarini , Riella Humberto Gracher , Fredel Marcio Celso
Published: June 2022

The present work details a case study for the valorization of the magnesium chloride hexahydrate waste MgCl2.6H2O, resulting from the magnesiothermic reduction of silica carried out to produce solar grade silicon, aiming to evaluate the potential use of this residue as raw material for the development of new products or sustainable applications. Thus, the systematic CPQvA evaluation was used, which aims to characterize the waste, using classification, potentiality, quantity/feasibility, and applicability criteria, to connectits potential application with the technological and environmental feasibility as alternative raw material. The chemical and mineralogical characterization of the MgCl2.6H2O residue (P-sub) was carried out, as well as an equivalent commercial product (P-com) for comparison purposes. The results indicated that the P-sub presents an excellent performance in terms of chemical composition and an adequate degree of purity for the application in the synthesis of nano-MgO nanoparticles with a high potential to produce nanofertilizers.
Percepção de professores sobre a trajetória histórica das práticas socioambientais da Escola Estadual Dom Joaquim de Almeida, Várzea-RN, Brasil
Authors: Silva Josinaldo Clemente da , Morais Virgínia Maria Magliano de , Silva Simone da , Souza Ramon Santos , Figueirêdo Sheilla da Silva Melo
Published: June 2022

Os problemas socioambientais cresceram significativamente nas últimas décadas, os cuidados e a preservação do meio ambiente devem se tornar uma prioridade para garantir a sustentabilidade. O estudo tem o objetivo de analisar as práticas e intervenções de educação ambiental realizadas na trajetória histórica das atuações de professores da Escola Estadual Dom Joaquim de Almeida, Várzea-RN, Brasil. Foi adotado uma metodologia de pesquisa mista, que combina métodos qualitativos e quantitativos. Foi utilizado para a coleta de dados aplicação de questionários direcionados aos professores ativos e inativos da instituição pesquisada. Registrou-se que as intervenções de educação ambiental foram realizadas através de ações participativas envolvendo a comunidade escolar de forma geral. A educação ambiental é um componente essencial para a ação contínua e permanente para a formação de sujeitos conscientes das questões ambientais socioambientais locais e globais, se fazem cada vez mais participativos, despertando os propósitos da sustentabilidade dos ecossistemas.
EMPOWERMENT OF WOMEN - A CONCEPTUAL FRAMEWORK
Authors:   Associate Professor, Department of Management, School of Commerce & Business Management, Central University of Tamil Nadu, Thiruvarur â€“ 610005,Tamil Nadu, India., Sreenivasa Murthy K.
Published: June 2022

The present paper throws a light on empowerment of women. Womens empowerment is obviously essential for raising their socio-economic status in the society. Recently, womens empowerment has acquired an important place in government policy, non- government advocacy and academic research. There has been a paradigm shift in development and governance. Democratic decentralization, partnership with NGOs, empowering community based organizations, participatory development, sustainable growth and equity etc., have proved to be instrumental in people participation in development and governance as well as their empowerment.
ANATOMICAL STUDY OF CORONARY ARTERIES AND ITS BRACHING PATTERN IN COSTAL ANDHRA PRADESH POPULATION
Authors:   Associate Professor Dept. of Anatomy, Jagannath Gupta Institute of Medical Sciences, Kolkata-700137, W.B., Babu Kannabathula Ajay , Lokanadam Sadhu ,   Associate Professor Dept. of Anatomy, Santhiram Medical College, Nandyal,Andhra Pradesh-518501., Sarkar Arpita ,   Assistant Professor Dept. of Anatomy, Jagannath Gupta Institute of Medical Sciences, Kolkata-700137, W.B. India.
Published: June 2022

Aim: The aim of this anatomical study of coronary arteries and its branching pattern in costal andhra pradesh population is to assess risk factors for occurrence of CADs. Methods: Conventional Dissection method. Results: Coronary artery disease (CAD) is a major cause of death and disability in developed countries, and incidence of CAD is increasing annually in the underdeveloped world. Today, percutaneous coronary intervention plays a major role both in diagnosis and treatment of CAD. This present study was done to assess the normal patterns of coronary arteries with reference to its origin, branching pattern, caliber, predominance, variations and anomalies. 100 adult male and female cadaveric and fresh hearts preserved with 10% formalin were obtained from the Department of Anatomy & Department of forensic, Rangaraya Medical College, Kakinada, Andhra Pradesh. The origins, various branching patterns and diameter of right and left coronary arteries were observed. Both RCA & LCA was originating from the anterior aortic sinus in 100% and LCA from left posterior aortic sinus in 100. In the present study, termination of RCA occurs between acute margin and crux of heart in 8% of specimens, at PIVA posterior Interventricular artery or crux of heart in 12% of specimens, in between crux and obtuse margin of the heart in 76% of specimens, at the obtuse margin of the heart in 4% of specimens. The main trunk of LCA divides into two branches (bifurcation) in 76% of specimens, into three branches (trifurcation) in 20% of specimens, into four branches (quadrifurcation) in 2% of specimen, into five (pentafurcation) branches in 2% of specimen. The minimum diameter of RCA was 2.5 mm. The maximum diameter ofRCAwas 3.9mm. The minimum diameter of LCA was 2.6 mm the maximum LCA diameter was 6.2 mm. In 100 specimens the posterior interventricular artery arose from the right coronary artery indicating right dominance in 90 specimens and in 10 specimens from the left circumflex coronary artery indicating left dominance. Right dominance was present in 90%, left dominance in 10% and co-dominance was nil. Variations in branching pattern of coronary arteries as reported in present study necessitate its importance for proper diagnosis and management of coronary artery disease. Conclusion: Arterial pattern and its variations are important to prevent false interpretation of the arterial angiograms in management of coronary artery diseases.
SYNTHESIS, PHYSICOCHEMICAL STUDIES AND BIOLOGICAL APPLICATIONSOF OXOVANADIUM(IV) COMPLEXES WITH SCHIFF BASES DERIVED FROM 3-PHENYL-4-AMINO-5-MERCAPTO-1, 2, 4-TRIAZOLES AND BENZIL
Authors:   Department of Chemistry, Tribhuvan University, Kathmandu, Nepal., Sharma M.L. , Srivastava A.K. ,   Department of Chemistry, DDU Gorakhpur University, Gorakhpur- 273009, India., Sharma B.P. ,   Department of Chemistry, Tribhuvan University, Kathmandu, Nepal., Marasini B.P. ,   Department of Biotechnology, National College, Tribhuvan University, Kathmandu, Nepal., Pandey O.P. ,   Department of Chemistry, DDU Gorakhpur University, Gorakhpur- 273009, India., Sengupta S.K. ,   Department of Chemistry, DDU Gorakhpur University, Gorakhpur- 273009, India.
Published: June 2022

A series of some mononuclear oxovanadium(IV) complexes have been synthesized by the reactions of oxovanadium(IV) sulfate with Schiff base ligands derived from 3-(phenyl / substituted phenyl)-4-amino-5-mercapto-1, 2, 4-triazoles of aromatic carboxylic acids and benzyl. The complexes were analyzed by different spectroscopic methods (FTIR, UV-Vis., EPR), X-ray diffraction (XRD) analysis, elemental analysis, conductivity measurement, and cyclic voltammetry (CV) analysis. The non-electrolytic nature of the complexes was determined on the basis of the molar conductance values. The powder X-ray diffraction pattern has also been used to determine crystal size and type. On the basis of the physicochemical data, the tentative square- pyramidal geometry of the complexes has been proposed. In vitro antibacterial andantidiabeticproperties by alpha amylase inhibition activities of the selected complexes have also been determined.
EXCLUSIONARY RULE PRINCIPLE AND CONSTITUTIONAL RIGHTS PROTECTION IN EVIDENCE SEEKING
Authors:   Faculty of Law. Lampung University, Bandar Lampung. Indonesia., Kurniawan Zahri , Tisnanta H.S ,   Faculty of Law. Lampung University, Bandar Lampung. Indonesia., Fakih M. ,   Faculty of Law. Lampung University, Bandar Lampung. Indonesia., Irzal Ferdiansyah Ahmad ,   Faculty of Law. Lampung University, Bandar Lampung. Indonesia.
Published: June 2022

The process of evidence seeking is often violations of constitutional rights. At this stage, the state authorizes law enforcers to carry out various coercive measures to obtain evidence. In many cases, the practice of violating constitutional rights in the evidence seeking raises the falses punishment. In Indonesia, coercive efforts to find evidence can be tested through pretrial institutions. Unfortunately, the existence of pretrial in Indonesia only test the formal truth of coercive measures and it is not yet authorized to examine the material truth. This article intends to explain the urgency and application of the exclusionary rule in various countries as well as the idea to push the regulation of exclusionary rules that allow judges to be not only examining judges but also investigating judges. Through this regulation, judges are expected to be able to examine formal and material actions as a control mechanism for the constitutional rights protection.
ADVANCING THE COMPLETION AGENDA IN ADULT DEVELOPMENTAL READING AT THE COMMUNITY COLLEGE LEVEL: A QUANTITATIVE RESEARCH STUDY
Authors:   Benedictine University in Partial Fulfillment of the Requirements for the Degree of Doctor of Education In Higher Education and Organizational Change This Dissertation Has Been Accepted For The Faculty of Benedictine University., Cathleen Revlock Therese , Wiles Kathleen ,   Dissertation Committee Director., Kolich Eileen ,   Dissertation Committee Chair., Korenman Tamara ,   Dissertation Committee Reader., Chand Sunil ,   Dissertation Committee Reader., Kolich Eileen ,   Program Director, Faculty., Ragland Ethel ,   Acting Dean, College of Educationand Health Services.
Published: June 2022

In order to assist community college students in completing their program of study at a more rapid pace, this quantitative, correlational study examined the effectiveness of acceleration as a method to help community college students complete the developmental reading sequence quickly and more successfully. Acceleration is a curricular redesign that includes challenging readings and assignments and reduces the number of required classes in the developmental sequence. Past research does not adequately measure student success in the current community college trend of securing the most efficient pathway possible for attaining an associates degree or career certificate. Students who scored 80 or higher on the post-course, COMPASS reading placement test skipped a developmental class and were eligible to take college-level gateway courses sooner, for the purpose of saving them time and money. Retention and grade-point-average of developmental reading students who pursued an accelerated path was compared to developmental reading students who followed the traditional, two-tiered course sequence to determine first year success. In the college of the study, findings indicated developmental reading intervention, regardless of model, was effective for the students who persisted, as measured by their literacy skill gains.
A CASE STUDY- TO EVALUATE THE EFFECT OFJALOUKAVCHARANAIN MANAGEMENTOF PISTAKA(PINGUECULITIS)
Authors:   Assitant Professor, Shalakya Tanta Dept., Shree AyurvedMahavidyalaya, Nagpur, Maharashtra., Tripathi Ankita , Pande Manoj ,   Associate Professor, swasthvirrataDept, Shree AyurvedMahavidyalaya, Nagpur, Maharashtra.
Published: June 2022

Introduction:A pinguecula is a yellowish non malignant lump that develops on the conjunctiva. It is Common degenerative condition of the conjunctiva, Yellowish white patch on the bulbar conjunctiva near the limbus. It swelled up due to deposition of fat, calcium,and protein will cause irritation leading to pingueculitis. Pingueculitis is the condition where the pinguecula remain inflamed and is vascularised. In our samhitas there is no direct reference available regarding the symptoms of Pingueculitis but by studying SushrutSmahita the sings, symptoms and aetiologyof PistakNetrarogamuch correlated with Pingueculitis. According to Acharya Shuhrut and YogratnakarRaktamokshanaand the treatment of kaphabhishanda useful in pistak. Aim: To Study the Role of Jaloukavacharana in the Management ofPistaka (Pingueculitis). Objectives: To study the role of jalokavacharana to reducing the sign and symptom of pistaka with special reference to pingueculitis. Methodology â€“ 1) Nidanparivarjana 2) Ahara -Vihara 3) Jaloukavcharana procedure. Result: The procedure Jaloukavacharanato reduce the sign and symptom ofpistak(pingueculitis). Conclucion: Ayurvedic procedure like Jaloukavacharnacan help inpistak (pingueculitis).
EVALUATION OF THE LEVELS OF PROFESSIONAL SATISFACTION AMONG BULGARIAN GENERAL DENTAL PRACTITIONERS: A PILOT STUDY
Authors:   Associate Professor, Department of Conservative Dentistry, Medical University, Sofia., V. Dimitrova Ivanka , Kouzmanova Yaneta ,   Assistant Professor, Department of Conservative Dentistry, Medical University, Sofia.
Published: June 2022

Background: In dental practice, the degree of professional satisfaction depends on a number of factors such as the duration of experience,personal characteristics of workers, factors of the working environment,income, socio-cultural factors such as the organization of the healthcare system and the attitudes of patients to dentists etc. The aim of this cross-sectional study was to evaluate the levels of job satisfaction of Bulgarian general dental practitioners. Materials and Methods: Subjects of observation in the study were 80 Bulgarian general dental practitioners. . The technical observation units in this study were individual and group practices for dental care located on the territory of Bulgaria. Results: 90.8% of all respondents were satisfied with their practice of dental medicine. The highest percentage of lack of professional satisfaction was registered in the group of general dentists with over 30 years of experience - 6.6% versus 1.3% for the group with up to 10 years and the group up to 30 years. Conclusion: Bulgarian general practitioners are with high average professional satisfaction and self-esteem from the practice of dental medicine - 90.8%.
DIRECT COMPRESSIBLE AND CO-PROCESSED EXCIPIENTS- A REVIEW
Authors:   Kailash Institute of Pharmacy & Management GIDA Gorakhpur., Kumar Vishwakarma Jai Narayan Mishra Dhaneshwar , Gupta Hema ,   Kailash Institute of Pharmacy & Management GIDA Gorakhpur., a Anuradha ,   Kailash Institute of Pharmacy & Management GIDA Gorakhpur.
Published: June 2022

The demands on the functionality of excipients are increasing day by day because of the emergence of high-speed tableting machines and the use of direct compression methods for tableting. Direct compressible is the preferred method for the preparation of tablet. Excipient play an important role in formulating a dosage form. these are the ingredient which along with active pharmaceutical ingredient make up the dosage forms. Excipient act as protective agent, bulking agent and can also be used sources of excipients along with their uses, and these Can be used for different activities. The current review article highlights the information about Direct compressible and co-processing excipients and their advantages. Also, the recent developments in excipient technology with special emphasis on natural combinations that could be used as co-processed excipients are briefly discussed.
BIVENTRICULAR NON-COMPACTION CARDIOMYOPATHY WITH LEFT VENTRICULAR DYSFUNCTION
Authors:   Department of Radiodiagnosis, Yashoda Hospital, Secunderabad- 500003, Telangana, India., Kumar DNB Naveen , A. DMRD , DNB. Surendar ,   Senior Consultant Radiologist, Department of Radiodiagnosis, Yashoda Hospital, Secunderabad- 500003, Telangana, India., S.Marda MD , DNB , FRCR , MMED Sapna ,   Senior Consultant Radiologist, Department of Radiodiagnosis, Yashoda Hospital, Secunderabad- 500003, Telangana, India.
Published: June 2022

Non-compaction of the ventricular myocardium involving both ventricles is a rare condition and characterized by deeply increased trabeculations in one or more segments of the ventricle. Non-compaction is thought to be due to intrauterine arrest of compaction of the loosely interwoven meshwork present in fetal myocardial primordium. More recent studies suggest that non-compaction of the ventricular myocardium can be acquired later on in life sporadically.The apical segment of the left ventricle is most commonly affected, but biventricular involvement is also described. Herein, we describe an unusual case of biventricular non-compaction cardiomyopathy with left ventricular systolic and diastolic dysfunction. A 54-year-old man presented with clinical heart failure as well as arrhythmia. Transthoracic echocardiography revealed left ventricular non-compaction with depressed ejection fraction. Cardiac magnetic resonance imaging (MRI) further revealed right ventricular noncompaction.
ATYPICAL MELANOMA MIMICKING A VASCULAR TUMOR : CLINICAL AND DERMOSCOPIC FINDINGS
Authors:   Department of Dermatology and Venerology, Ibn Rochd University Hospital, Casablanca, Morocco., Rabba Sabrine , Hali Fouzia ,   Department of Dermatology and Venerology, Ibn Rochd University Hospital, Casablanca, Morocco., Diouri Mounia ,   Department of Plastic Surgery, Ibn Rochd University Hospital, Casablanca, Morocco., Marnissi Farida ,   Department of Pathology, Ibn Rochd University Hospital, Casablanca, Morocco., Chiheb Soumiya ,   Department of Dermatology and Venerology, Ibn Rochd University Hospital, Casablanca, Morocco.
Published: June 2022

Introduction: Completely amelanotic melanomas are rare and therefore often misdiagnosed. Analysis of dermoscopic features of the vascular pattern appears to be a reliable method to suggest these particular diagnosis. Case Presentation: we report a case of an atypical primary cutaneous melanoma of plantar localization which clinically mimicked an angiomatous tumor. Clinical examination showed an angiomatous lesion of 10 cm long axis, located on the lateral part of the left sole. The two adjacent nodules measured 3 cm each, one was angiomatous and the other erythematous. There were also multiple left inguinal adenopathies. Dermoscopic evaluation of the lesion revealed the lack of a pigmented network and a rich vascular bundle made of polymorphous linear vessels, dotted vessels, white lines and milky red areas. The patient underwent excision of an angiomatous nodule. The definitive diagnosis was provided by immunohistochemistry (tumor cells expressed S100 and Melan A). . Brain and thoracic-abdominal-pelvic CT scan showed bilateral nodular lung involvement and a segment VI liver lesion. We concluded to the diagnosis of a primary amelanotic metastatic melanoma stage 4. Clinical Discussion: The term amelanotic refers to tumors that have no pigmentation on visual and dermoscopic inspection. Amelanotic and hypomelanotic melanomas are rare. They could mimic many benign and malignant tumors. There are three forms of AM. The papulonodular form represents 58% and could be misdiagnosed as a vascular tumor, which was the case of our patient. The contribution of dermoscopy is valuable in the clinical orientation in case of amelanotic melanoma. There is a correlation between the stage of the melanoma and the vascular pattern(s) observed as well as their distribution. The prognosis of amelanotic melanoma is characterized with a lower survival rate and a high risk of recurrence. The treatment of amelanotic melanoma is similar to the pigmented counterpart. Conclusion: In order to avoid therapeutic delay, melanoma should be considered whenever there is a suspicious plantar lesion even in the absence of pigmentation. Dermoscopy is a non-invasive technique that could help in the diagnosis.
SEDATION IN COLONOSCOPY: WHATTHE EFFECT-SITE CONCENTRATION OF PROPOFOL IN TARGET-CONTROLLED INFUSION FOR WHICH THE ACTBECAMECOMFORTABLE AT THE INTRODUCTION OF COLONOSCOPE?
Authors:   Department of Anesthesiology and Critical Care, MilitaryTeaching HospitalMohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed VUniversity of Rabat, Rabat, Morocco., Hammadi Hicham
Published: June 2022

Method: Prospective observational study carried out over 5 months, with the objective of determining the effect-site concentration of propofol in target-controlled infusion anesthesia which allows the introduction of a colonoscope under the best conditions.84 patients aged 18 to 71 are included: 38% were male and 46% female, with 57% classified as ASA I and 43% as ASA II. Results: Among the 84 patients: 47.6% had no history, 11.9% hypertensive, 14.3% diabetic, 21.4% dyslipidemic, 4.8% followed for stable heart failure. Reflex loss concentrations averaged 3.78 ug/mL with a minimum of 2.6 ug/mL and maximum of 4.8 ug/mL.While the target concentrations of the introduction of colonoscope which allows comfort for the gastroenterologist and the patient were on average 5.24 ug/mL with a minimum of 3.4 ug/mL and maximum of 6.8 ug/mL.
EVALUATION OF EFFICACY OF BARBED SUTURES IN INTRAORAL WOUND CLOSURE
Authors:   Post Graduate Resident, Dept. Of Oral & Maxillofacial Surgery, Bapuji Dental College & Hospital, P O Box #326, Davangere- 577004 Karnataka, India., Sarkar Debasmita , G. Naik Vinayak ,   Reader, Dept. Of Oral & Maxillofacial Surgery, Bapuji Dental College & Hospital, Davangere- 577004 Karnataka, India., Kumar Rai Kirthi ,   Prof. & Head of Dept. Dept of Oral & Maxillofacial Surgery, Bapuji Dental College and Hospital, Davangere 577004.
Published: June 2022

Background and Objective: Surgical knots though provides an anchoring function on suture line, but also present a potential source of infection. Knotless barbed sutures were designed to prevent knot-related complications. The aim of this study was to determine the safety, effectivity and longevity of unidirectional barbed sutures in intraoral wound closure. Materials and method: A non-randomised study involving 13 patients who required intraoral incisions for open reduction and internal fixation of mandibular fractures and alveoloplasty. Following the surgical procedures, wound closure was done by unidirectional barbed sutures. Outcome parameters that were measured were type of healing, erythema, wound discharge, wound dehiscence, necrosis and pus on 3rd and 7th post-operative day and 2nd and 4th post-operative week. Results: Statistically significant change in healing and erythema status was observed in the group (P value < 0.001) across the timeline. No statistical significance was found for other parameters. Dehiscence of sutured wound was observed on the same day of the procedure in one patient. Suture extrusion was also noticed in one patient after 1st postoperative week. Conclusion: Knotless barbed sutures can be used without harm in wound approximation of intraoral incisions with no potentially harmful major or minor complications.