bluuebunny/crossref_metadata_2025 huggingface dataset:
Cancel Culture in Constructing National Identity of the Caspian Macro-region Countries (on the Example of Textbooks in Kazakhstan and Turkmenistan)
Authors: Khlyshcheva E. V. , Tikhonova V. L.
Published: June 2023

The process of the formation of independent states on the territories of post-Soviet republics raised the problem of the construction of their national identities. This process was propelled by the rejection of Soviet identity and the cultural legacy of the Soviet era. This rejection necessitated a reinterpretation of the historical past of the nations and a revision of the pantheon of national heroes. To achieve this goal, the mechanism of cancel culture was used, which aimed at rejecting the values of a certain culture and constructing a new worldview. In this research, we are interested in the Caspian macro-region, which is an object of interest both geopolitically and economically not only for the five international actors (Russia, Turkmenistan, Kazakhstan, Iran, Azerbaijan) having access to the water area but also for more distant states (China, Turkey, the USA, and leading European countries) fighting for influence in the Caspian basin. In the Caspian region there is heightened tension, manifested in ethnic conflicts (Armenian-Azerbaijani, Kazakhstan, Iran, etc.), therefore the study of the process of national identity construction in each subject individually and in the whole region is not only a matter of scientific interest but also a strategic task to ensure both Caspian and Russian security. The main purpose of the article is to analyze the mechanisms of constructing a new national identity of the Caspian countries through the cancel culture, reconsidering their experience and historical development. This process can be seen most clearly in the example of changes in the educational systems of the Caspian region countries. To conduct a comparative analysis, we took history and local history textbooks from secondary schools and institutions of higher education in the republics of Kazakhstan and Turkmenistan. This research was limited to the study of textbooks published in the Russian language. The selection was made by random sampling. A series of research projects on the construction of national identity in the post-Soviet space through the mechanism of cancel culture starts with this article presenting the results of the study of two countries in the Caspian Sea region — Kazakhstan and Turkmenistan.
VII International Student Research Conference the Role of the Russian Language in International Relations
Authors: Belyakov M. V.
Published: June 2023

On April 10, the 7th International Student Research Conference organized by the Russian Language Department was held at MGIMO University. This year the conference was devoted to the role of the Russian language in international relations. The conference was aimed at stimulating the research and project activities of young scientists in the field of studying the Russian language and its use in the field of scientific and professional communication. The opening plenary session included speeches by MGIMO professors M. V. Belyakov, A. A. Vasilyeva, N. D. Afanasyeva, and the Head of Science Department of RUDN U. M. Bakhtikireeva. The plenary session was followed by breakout sessions in two topic areas. The conference was attended by dozens of university students from Russia, from neighboring and distant foreign countries, including Turkey and China. Students delivered reports on various subjects, including the role of the Russian language in international politics and diplomacy, the Russian language in the context of the dialogue of cultures, the reflection of the national culture in the Russian language, the role of the Russian language in the post-Soviet space, etc. This event is held twice a year to give young scientists a venue to share the results of their research and serves as a discussion platform. Summing up, the participants noted the scientific and practical significance and relevance of the materials presented at the conference, the high professionalism of the speakers, the clear and high-quality organization of the conference, and expressed their gratitude to the organizers.
Do Shia-Sunni Tensions Affect Iranian-Saudi Relations?
Authors: Podrezov M. A.
Published: June 2023

Today the rivalry between Iran and Saudi Arabia is one of the defining factors in the Middle East political arena. The Islamic world's division into Shiite and Sunni is often considered a factor affecting bilateral relations between Tehran and Riyadh. Iran positions itself as the center of gravity for all the Shiites in the region, while Saudi Arabia seeks to form an anti-Iranian alliance on a Sunni basis. This article assesses the impact of the doctrinal tensions between these two branches of Islam on the Iranian approach towards its relations with Saudi Arabia. For this purpose, the author analyses the rhetoric of Iranian officials, clerics, and state-run media in the context of the main concepts of the Iranian contemporary religious ideology. The author concludes that criticism of Saudi Arabia has lost its religious connotation and Tehran does not position its confrontation with Riyadh as a fight against the enemies of Islam or apostates. The traditional epithets classifying their holders as supporters of the forces of darkness and actively used against the Western countries and Israel are not cited by critics of the Saudi dynasty. Moreover, the criticism of Wahhabism as a religious movement is not linked to the kingdom's current political leadership. On the contrary, the Iranian criticism of the Saudi foreign and domestic policies focuses on condemning the Saudi authorities' infringement on human rights and media freedom, supporting the protest movement in Iran, and fighting the Houthis. Even the persecution of Shiites in Saudi Arabia, to which the Iranian press has devoted considerable attention, is viewed from the perspective of the global concept of human rights, rather than as the struggle of one religious group against another. The kingdom itself is not considered an ideological enemy of Iran, which since the Islamic Revolution has been the US and Israel. The statements by some representatives of the Iranian political establishment on the need for peaceful coexistence between the two countries, along with the March 2023 agreements on normalizing bilateral relations indicate Tehran's pragmatic approach to interaction with Riyadh which is not affected by the ShiaSunni controversy in its dogmatic and religious dimensions.
Ancient Understanding of Time and the Background of Contemporary Historicism
Authors: Gorin D. G.
Published: June 2023

Contemporary changes in historical culture associated with various states of modernity actualize the problem of the foundations and prerequisites of historicism as a principle of thinking characteristic of modern societies. The ancient historicism background consists primarily in the advanced concepts of time and eternity, which contain the potential variability in the understanding of historicity in modern philosophy and culture. At the same time, the problem of the historical variability of the world remained on the periphery of ancient philosophy and culture, and classical historicism, which was established in the second half of the 18th century, was based on the rejection of some aspects of the ancient heritage. In opposing being and becoming, ancient philosophy preferred being, which was also manifested in the preference for truth over time, for one over multiple. Classical historicism of modern times is focused on the idea of becoming, which in a new way reveals the contradictions between truth and time, one and multiple. Relativism and plurality are becoming features of modern transformations of historicism, in which the structures of time are preserved, dating back to the ancient concepts of chronos, kairos, eon, etc. Of particular interest are modern ideas about time, which go back to the ancient concept of objectified chronological time and its correlation with other forms of time conceptualization. In the historical consciousness of modern times, the ancient concepts of time were transformed under the influence of the prophetic sense of time, characteristic of the biblical tradition, in which the historical process is considered in the context of the gradual revelation of the original intention and meaning of history.
Types and Role of Bows in Modern Vietnamese Culture
Authors: Glazunova S. E. , Morozova E. B.
Published: June 2023

Recent decades have seen a drastic increase of academic interest in non-verbal communication of various ethnic groups. However, gestural behaviour of the Vietnamese, particularly in the sphere of etiquette, has been rarely analyzed by modern scholars. Research papers on this topic describe etiquette gestures of Vietnamese culture, especially bows, vaguely and sketchily. Although in the past bows used to be widespread in Vietnam, nowadays the gesture seems to have lost its popularity, in comparison with Vietnam’s regional neighbours, such as China, South Korea or Japan. During the preliminary stage of the research, we identified many problem areas concerning rules and situations when people must bow, types, names, and physical forms of Vietnamese bows, which defined the purposes of the research. The goals of the paper are to analyze and systemize the descriptions of Vietnamese bows, rules and situations of their use collected in research literature; to analyze current articles on bows, published by Vietnamese media to understand public opinion about bows and to conduct an online-survey of Vietnamese people (71 people) to obtain additional data, which will help to get more accurate and up-to-date information on the subject. The objective of the research is to identify the role and types of bows in modern Vietnamese culture. The results of the paper show that Vietnamese culture has two basic types (forms) of bows — vái and lạy, with many reduced and intermediate forms, and a nod, which do not have any specific names and require further investigation. The research also identifies numerous etiquette situations where bows are still used and describes rules of bowing in three major contexts of social interaction, such as religious, ceremonial and every-day communication. The results of the media articles and survey analyses show that bows, banned by the Vietnamese Communist Party several decades ago, are gradually starting to acquire more significance in modern society than they had in the past, particularly in business sphere and during religious worships. The results of the paper are not final as the research has outlined new vectors and areas of investigation that require field studies in the country.
THE MULTIFACETED SKILL SET OF SUPERVISORS
Authors: Auer Natalia
Published: June 2023

In recent years, PhD students experience a decrease in quality of doctoral education. Less supervision, cancellation of courses, and lack of research resources are reported as factors having an impact on the quality of supervision. Supervision requires different skills since there are several aspects involved including a shared responsibility at departmental level, the context for supervision within the academy and the power relations, supervision relationships, and the way the assessment is conducted.
Percepción de los docentes sobre las estrategias para mejorar la alimentación de estudiantes de educación básica en tiempos de Covid-19
Authors: Priego-Bravo Andrea , Castillo-Ruíz Octelina , González-Pérez Ana Luisa , Almanza-Cruz Ocairi , Ríos-Reyna Candelaria , Aleman Castillo Sanjuana
Published: June 2023

Objetivo: identificar las percepciones sobre las estrategias para mejorar la alimentación de estudiantes de educación básica en tiempos de Covid-19. Metodología: estudio cualitativo en el que participaron 45 docentes que pertenecían a escuelas públicas y privadas, se aplicó una entrevista semiestructurada a través de formularios de Microsoft Forms (Office 365, Microsoft). Resultados: de acuerdo con la percepción de los/as profesores/as, los padres no fomentan una alimentación saludable en sus hijos, por falta de conocimiento, ambos padres trabajan o por indiferencia, el 20.0% de los profesores mencionaron que una de las estrategias para mejorar la alimentación de los escolares fue la capacitación que les ofrece la Secretaría de Educación Pública (SEP), sin embargo, el 78.0% considera que el nutriólogo debe impartir estos temas por su formación académica. Limitaciones: es una muestra representativa de las escuelas públicas y privadas, no se profundiza sobre el consumo de alimentos de los escolares durante el horario de clases. Conclusiones: la percepción de los profesores fue que los nutriólogos son los más capacitados para establecer estrategias y programas de educación nutricional con seguimiento para mejorar la alimentación de los escolares, debido a que los padres no lo fomentan.
Железообрабатывающее производство средневекового археологического комплекса Анюшкар в Верхнем Прикамье
Authors: Смертин Андрей Романович
Published: June 2023

В статье вводятся в научный оборот результаты археометаллографического анализа железных предметов из городища и могильника Анюшкар (Кыласово) (X–XV вв.) Выявлено, что на поселении находились все объекты для обеспечения полного цикла железоделательного и железообрабатывающего производства: рудные выходы, плавильные и кузнечные горны. Описаны основные технологические схемы кузнечных изделий местного производства (трёхслойный пакет в восточноевропейском варианте) и импорта (трехслойный пакет в североевропейском варианте, косая наварка, вварка) и др. Впервые проанализирована серия кузнечных полуфабрикатов, благодаря чему удалось выявить стадиальность прикамской железообработки. В целом, прослеживается высокий уровень мастеров, которые владели выразительным набором кузнечных операций, имея, однако, некоторые пробелы в знании свойств металла.
Pengaruh penyakit jantung bawaan sianotik dan asianotik terhadap pertumbuhan pasien balita periode 2018-2020 di RSUD Dr. Chasbullah Abdul Majid Bekasi
Authors: Putri Syifa Prajastuti , Ariwibowo David Dwi
Published: June 2023

Penyakit jantung bawaan (PJB) ialah kelainan struktur dan fungsi jantung yang didapati sejak dalam kandungan. Penyakit jantung ini diklasifikasikan menjadi dua kelompok, yaitu PJB sianotik dan asianotik. Salah satu komplikasi dari PJB adalah gangguan pertumbuhan. Studi ini dilakukan untuk melihat pengaruh penyakit jantung bawaan terhadap pertumbuhan pasien balita dengan PJB. Studi analitik observasional dengan metode potong lintang ini dilakukan di RSUD dr. Chasbullah Abdul Majid Kota Bekasi. Pengumpulan data dilakukan dengan mengobservasi data sekunder yang didapat melalui rekam medis. Pengambilan sampel menggunakan teknik total sampling. Analisis hubungan antar variabel menggunakan uji chi-square. Sampel studi ialah 43 balita yang terdiri dari 15 balita dengan PJB sianotik dan 28 balita dengan PJB asianotik. Sebanyak 28 (58%) balita memiliki berat bada kurang hingga sangat kurang dan sebanyak 20 (46,5%) balita memiliki panjang/tinggi badan pendek hingga sangat pendek. Hasil analisis menunjukkan adanya  hubungan yang bermakna antara penyakit jantung bawaan sianotik dan asianotik terhadap berat badan (p-value = 0,006; PRR = 2,02) maupun panjang/tinggi badan (p-value = 0,001; PRR = 2,8). Kesimpulan studi ini ialah keadaan sianotik pada penyakit jantung bawaan lebih besar memengaruhi pertumbuhan balita dibandingkan PJB yang asianotik.
Pengaruh status gizi terhadap kualitas tidur pada mahasiswa kedokteran Universitas Tarumanagara
Authors: Hidayat Adjra Safira , Charissa Olivia
Published: June 2023

Status gizi seseorang dipengaruhi oleh beberapa aspek keturunan, pola hidup, serta lingkungan sekitar. Kualitas tidur merupakan salah satu faktor yang disebabkan oleh pola hidup seseorang. Berdasarkan penelitian di Yogyakarta menemukan bahwa kualitas tidur yang buruk sebanyak 54%. Hal tersebut terjadi pada fase remaja berusia 12 hingga 24 tahun. Obesitas merupakan salah satu masalah status gizi yang berdampak pada kualitas tidur seseorang yaitu sleep apnea. Berdasarkan permasalah tersebut perlu adanya penelitian mengenai hubungan status gizi dengan kualitas tidur sesorang. Dalam penelitian ini diusulkan bagaimana sebaran distribusi status gizi dan kualitas tidur serta bagaimana hubungan antara status gizi dan kualitas tidur pada mahasiswa Fakultas Kedokteran Universitas Tarumanegara. Penelitian ini disusun dengan metode analitik observasional dengan desain studi cross sectional tersistematis. Data yang digunakan yaitu status gizi, tinggi badan, berat badan, usia, jenis kelamin, serta kualitas tidur. Hasil studi didapatkan bahwa tidak terdapat hubungan yang bermakna antara status gizi kurang dengan kualitas tidur dengan p-value 0,403 dan tidak ada hubungan yang bermakna antara status gizi lebih dengan kualitas tidur dengan p-value 0,316. Kesimpulan studi ini adalah tidak terdapat hubungan bermakna antara status gizi dengan kualitas tidur mahasiswa kedokteran Universitas Tarumanagara.
Pengetahuan, sikap dan perilaku ibu hamil mengenai kurang energi kronis
Authors: Novendy  , Irawaty Enny , Cahyani Hapsari Mustika , Sunardi Cindy Paramitha , William Randy
Published: June 2023

Kasus kurang energi kronis pada ibu hamil di Puskesmas Kronjo tahun 2021 terdapat sebanyak 2,8%, meningkat menjadi 4,5% kasus pada bulan Agustus 2022. Hasil mini survei yang telah dilakukan di Puskesmas menunjukkan bahwa pengetahuan masyarakat mengenai penyakit kurang energi kronis masih kurang. Selain itu studi terkait pengetahuan, sikap dan perilaku mengenai kurang energi kronis pada ibu hamil di Puskesmas Kronjo belum dilakukan sehingga studi ini sangat perlu dilakukan sebagai data awal gambaran masyarakat mengenai penyakit ini. Studi ini menggunakan desain potong lintang. Teknik sampling untuk mengambil 157 responden yang digunakan ialah purposive non-random sampling. Data diperoleh dengan menggunakan kuesioner yang berisi seputar pengetahuan, sikap dan perilaku ibu hamil mengenai penyakit kurang energi kronis. Data kemudian disajikan dalam bentuk data deskriptif. Hasil penelitian menunjukkan hampir setengah yaitu sebesar 47,8% pengetahuan responden masih kurang mengenai penyakit kurang energi. Namun, sebesar 85,4% responden memiliki sikap yang baik serta 78,3% reponden memiliki perilaku yang baik mengenai penyakit kurang energi kronis. Edukasi kepada ibu hamil mengenai penyakit kurang energi kronis tetap harus dilakukan sebagai upaya mencegah timbulnya kurang energi kronis pada ibu hamil dan ibu dapat melahirkan bayi yang sehat.
Tingkat pengetahuan tentang tindakan pencegahan malaria berdasarkan karakteristik masyarakat Kabupaten Merauke periode tahun 2022
Authors: Latumahina Fanya Felicia Nadin , Song Chrismerry
Published: June 2023

Malaria merupakan salah satu penyakit tular vektor nyamuk Anopheles betina dan sering menyebabkan tingkat mortalitas yang tinggi. Malaria masih menjadi masalah kesehatan terutama di wilayah Papua termasuk Kabupaten Merauke yang merupakan wilayah endemis. Penyakit ini dapat dicegah dan dibutuhkan penyebaran informasi kepada masyarakat terutama daerah endemis. Studi ini bertujuan untuk mengetahui tingkat pengetahuan mengenai pencegahan malaria berdasarkan karakteristik masyarakat Kabupaten Merauke. Studi deskriptif cross-sectional ini dilakukan di Kabupaten Merauke khususnya di Kelurahan Mandala, Kelurahan Karang Indah, dan Kelurahan Samkai. Jumlah subjek studi sebanyak 300 orang yang dibagi menjadi 100 subjek pada setiap kelurahan dan diambil dengan  metode consecutive sampling. Data studi diperoleh menggunakan kuesioner tingkat pengetahuan mengenai tindakan pencegahan malaria. Hasil studi ini didapatkan mayoritas subjek memiliki tingkat pengetahuan yang cukup (194 subjek; 64,7%). Tingkat pengetahuan masyarakat mengenai pencegahan malaria paling tinggi pada usia 15-30 tahun yaitu sebanyak 34.6% (44/127), dan didapatkan bahwa semakin tinggi tingkat pendidikan responden, semakin tinggi pula tingkat pengetahuan responden, yaitu pada tamatan SMA sebesar 35.9% (51/142), S1 sebesar 71.1% (37/52), dan S2 sebesar 100% (3/3). Masyarakat yang belum pernah menderita malaria sebelumnya memiliki tingkat pengetahuan yang lebih tinggi yaitu sebanyak 38.3% (18/47) dibandingkan yang pernah terinfeksi (31,2%; 79/253). Kesimpulan dari penelitian ini adalah masyarakat Kabupaten Merauke mayoritas memiliki tingkat pengetahuan yang cukup mengenai pencegahan malaria, tingkat pengetahuan lebih baik pada masyarakat yang memiliki riwayat tingkat pendidikan lebih tinggi dan tidak pernah menderita malaria.
Pengaruh pemberian jus tomat dan jus buah naga terhadap kadar gula pasien diabetes di Puskesmas III Kelurahan Peguyangan Kaja
Authors: Swandesi Ni Wayan Ela , Tjandra Oentarini
Published: June 2023

Diabetes melitus ialah keadaan kadar gula darah dalam tubuh berlebih akibat kurangnya insulin. Jus tomat dan jus buah naga merupakan terapi nutrisi yang diaplikasikan untuk menangani penyakit diabetes melitus. Tomat (Solanum lypersicum) memiliki kandungan likopen yang memiliki fungsi untuk menangkal radikal bebas dan buah naga (Hylocereus undatus) memiliki banyak kandungan antioksidan dan serat. Kedua buah ini banyak diklaim dapat menurunkan kadar gula darah. Tujuan studi ini adalah mengetahui pengaruh pemberian jus tomat dan jus buah naga terhadap kadar gula darah pada pasien diabetes melitus di wilayah kerja Puskesmas III Kelurahan Peguyangan Kaja. Studi dilakukan dengan desain quasi eksperimental melalui two group pretest-posttest design pada Januari-Maret 2021. Data diolah dengan analisa univariat dan bivariat dengan uji Wilcoxon signed-ranks. Hasil studi didapatkan rerata kadar gula darah sebelum dilakukan pemberian jus buah naga yaitu 181±29,15 mg/dL, setelah dilakukan pemberian jus buah naga kadar gula darah turun menjadi 162±25,22 mg/dL (p-value = 0,003). Rerata kadar gula darah sebelum dilakukan pemberian jus tomat yaitu 173±33,53 mg/dL, setelah pemberian jus kadar gula darah turun menjadi 157 mg/dL±22,34 mg/dL (p-value = 0,001). Pemberian jus buah naga dan jus tomat memiliki pengaruh terhadap penurunan kadar gula darah pasien diabetes melitus di wilayah kerja Puskesmas III Kelurahan Peguyangan Kaja.
Gambaran konsumsi minuman pada konsumen dewasa muda di kedai kopi kawasan Jakarta Timur
Authors: Widodo Veronica Melia , Lontoh Susy Olivia
Published: June 2023

Tingkat konsumsi minuman kopi di Indonesia semakin meningkat terutama di kota-kota besar. Saat ini, minuman kopi makin banyak dinikmati oleh kalangan dewasa muda. Faktor yang dapat meningkatkan hal tersebut datang dari adanya tuntutan pekerjaan, gaya hidup, kurangnya waktu tidur, dan rasa ketergantungan sebagai sumber energi alternatif yang mudah didapat. Sifat ketergantungan dan peningkatan konsumsi minuman kopi memberikan dampak di bidang kesehatan. Tujuan studi ini ialah untuk mengetahui gambaran konsumsi minuman khususnya minuman kopi pada konsumen kategori usia dewasa muda di kedai kopi kawasan Jakarta Timur. Studi ini menggunakan metode observasional deskriptif dengan teknik pengambilan sampling yakni non-probability sampling. Pengambilan data untuk mengetahui karakteristik konsumsi minuman responden menggunakan Food Frequency Questionnaire (FFQ) yang sudah dimodifikasi sesuai tujuan studi. Hasil studi menunjukkan bahwa 63,3% subjek lebih memilih minuman kopi sedangkan sisanya tidak. Jenis minuman yang paling digemari oleh sebagian besar subjek studi ialah kopi susu dengan tingkat konsumsi sedang (3-6 cangkir per minggu).
Effect of Clinical Decision Support System and Clinical Pharmacists’ Practice in Preventing Drug-drug Interactions among Inpatients in Bac Ninh General Hospital
Authors: Thanh Hai Nguyen , Thi Thuy Van Pham , Cong Thanh Ly , Thi Lap Luong , Khanh Linh Can , Xuan Bach Nguyen
Published: June 2023

Drug-drug interaction is one of the drug-related problems that can reduce therapeutic efficacy or increase the risk of undesirable effects. Subjects and methods: interventional study design with before-after comparison. In the pre-intervention period, we retrospectively carried out all electronic prescriptions and medical records of inpatients treated from 01/11/2021 to 31/01/2022. In the post-intervention period, we prospectively performed monitoring reports on the drug-drug interaction warning system and medical records of inpatients from 01/02/2022 to 31/03/2022. Results: The proportion of patients exposed to drug-drug interactions (DDIs) decreased significantly from 4.27% in the pre-intervention period to 3.56% in the post-intervention period (p<0.05). There were no medical records with contraindicated DDIs in the post-intervention period. The percentage of patients for contraindication DDIs with conditions determined to patients with the condition was 39.33% and 27.59%, respectively, in the pre-and post-intervention phases. Medical records rate with major DDIs decreased significantly in the post-intervention period (2.95% vs 3.68%; p<0.05). Conclusion: Clinical decision support systems with drug-drug interaction warnings and clinical pharmacy activities help to reduce the frequency of DDIs. The results show that the combination of these two measures initially brings about effective DDIs management in hospitals.
Research of Clinical and Paraclinical Characteristics of Laryngeal Cancer of National Otorhinolaryngology Hospital of Vietnam from 11/2022 to 4/2023
Authors: Xuan Nghia Ha , Tuan Son Nguyen , Dinh Linh Dao , Thi Nhung Le , Duc Duy Pham , Trung Duy Nguyen
Published: June 2023

Objectives: studying clinical and paraclinical characteristics of laryngeal cancer. Patients and methods: 31 laryngeal cancer patients were diagnosed and treated in the Oncology Department of the national otorhinolaryngology hospital of Vietnam from 11/2022 to 4/2023 by a cross-sectional descriptive study. The results: patients having the most common age range was 60-80 occupied 52.8%, and the mean age was 60.5 ± 9.4, ranging from 35 to 80. Males occupied 97.2% (35/36), females 2.8% (1/36). The most common functional symptom was hoarseness with 94.4%. The mean time of symptom onset was 5.9 ± 6.1, ranging from 1-36 months. The most common tumor site is the vocal cords, accounting for 97.2% of endoscopic and 80.6% of CT SCAN findings. Squamous cell carcinoma accounts for 100%. Tumors in stage I account for 50%. Surgery is the main treatment (75%). Conclusion: Laryngeal cancer is one of the cancers with a high rate in our country. The symptoms are usually non-specific, with hoarseness being the most common symptom. The common form of the disease is squamous cell carcinoma, and surgical treatment at an early stage is the main method.
Protein Drug Production
Authors: Hue Linh Nguyen , Thi Minh Hue Pham , Thi Mai Anh Nguyen , Thi Thuong Bui , Van Khanh Nguyen , Thi Thanh Binh Nguyen , Thi Hai Yen Nguyen , Kim Thu Dang , Thanh Tung Bui , Minh Koong Tu , Thanh Hai Nguyen
Published: June 2023

The group of protein drugs has been developing very strongly, promising great advances in diagnosis, treatment, prevention, and human health improvement. Protein drug production is a large area of research, requiring advanced scientific and technological expertise, and integration of multi-disciplinary technology from fields such as biology, genetics, biotechnology, protein extraction and purification, and pharmaceutical manufacturing.

As protein drug manufacture involves biosynthesis processes using different cell lines, biopharmaceuticals have some distinct characteristics from small-molecule synthetic drugs, such as variability of biological processes, diversity of synthetic proteins, therefore leading to some differences in research and development, approval procedures, bioactivity testing, quality control and quality assurance and the production of “generic” biopharmaceuticals - biosimilars.

This article provides an overview of protein drug production from the initial stage to the finished product process, to identify and promote training activities, research and development, and knowledge transfer, contributing to the development of the biopharmaceutical industry in Vietnam, as well as effectively applying the drugs in clinical practice. Protein drug production is a valuable industrial field, with the goal of not only protecting and taking care of people's health but also developing national research, manufacturing, scientific and technological capacity, and bringing economic value.

Keywords: Protein drug, biopharmaceuticals, formulation, biosimilars.
Eksik tahrikli bir sistemin karınca kolonisi tabanlı optimal PD kontrolü: Deneysel bir uygulama
Authors: BIÇAKÇI Sabri , KILIÇ Fuat , GÜNEŞ Hüseyin
Published: June 2023

Ters sarkaç sistemi (IP) eksik tahrikli, doğrusal olmayan, kararsız ve kontrolü karmaşık bir sistemdir. Bu çalışmada ters sarkaç sistemi, sürtünme etkileri de dikkate alınarak modellenmiştir. Sistemin kontrolü için katsayıları karınca kolonisi algoritması yardımıyla ayarlanan araba konumunu ve sarkaç açısını kontrol eden paralel PD kontrolcüsü önerilmiştir. Karınca kolonisi algoritmasına bağlı olarak ideal oran ve türev katsayıları hatanın karesinin integrali (ISE), hatanın mutlak değerinin integrali (IAE), zamana bağlı olarak hatanın mutlak değerinin integrali (ITAE) ve ortalama karesel hata (MSE) amaç fonksiyonları yardımıyla elde edilmiştir. Sistemin performansı, konum ve açı kontrolcüleri için bulunan katsayılar yardımıyla klasik PD kontrolcü ile karşılaştırmalı bir şekilde benzetim ve deneysel olarak incelenmiştir. Elde edilen sonuçlara göre, yükselme zamanı, oturma zamanı ve aşma değerleri azaltılmıştır. Adım referansta, optimizasyonları sağlanan paralel PD kontrolcülerin cevap performansı önemli derecede arttırılmıştır.
EVALUASI DAN OPTIMASI SUMUR GAS LIFT DENGAN MENDESAIN ULANG PADA SUMUR DA-011
Authors: Amalia Ramadhanty Dinda , Sulistyanto Djoko , Karyadi Oetomo R. Hari
Published: June 2023

Sumur DA-011 merupakan sumur yang menggunakan pengangkatan buatan atau artificial lift berjenis gas lift. Prinsip kerjanya mengangkat fluida ke permukaan dengan cara menginjeksikan gas bertekanan tinggi. Diketahui bahwa jenis gas lift yang digunakan adalah continuous gas lift. Terdapat beberapa permasalahan yang sering terjadi dalam pengoperasian sumur gas lift. Salah satu permasalahan yang terjadi pada sumur DA-011 ialah kebocoran pada valve yang terpasang. Kebocoran valve tersebut ditandai pada hasil pressure traverse survey. Dimana titik injeksi sumur DA-011 berada pada gas lift valve ke-1 yang seharusnya beroperasi pada valve ke-7. Sehingga, perlu dilakukan evaluasi dan analisa kondisi sumur DA-011 sebelum dilakukan desain ulang untuk mengganti valve yang terpasang sebelumnya. Desain ulang dilakukan menggunakan spreadsheet. Bertujuan mendapatkan laju gas injeksi, letak kedalaman masing-masing valves, dan mengetahui titik injeksi yang optimum. Selain itu, software pipesim digunakan untuk menganalisa kondisi sumur menggunakan Gas Lift Performance Curve untuk mengetahui laju gas injeksi dari valve yang terpasang. Setelah melakukan analisa sumur DA-011, dilakukannya desain gas lift menggunakan software pipesim sebagai perbandingan desain gas lift menggunakan spreadsheet. Saat terjadi kebocoran valve, sumur DA-011 menginjeksikan gas sebesar 0,418 mmscfd menghasilkan laju produksi sebesar 247 blpd dan laju produksi minyak sebesar 9,88 bopd. Sedangkan saat optimasi sumur, sumur tersebut dapat menginjeksikan gas sebesar 0,8 mmscfd menghasilkan laju produksi sebesar 1900 blpd dan laju produksi minyak sebesar 76 bopd. Perbandingan antara desain spreadsheet dengan desain pipesim dalam optimasi gas lift ialah desain spreadsheet memperoleh 4 unloading valve dan 1 operating valve. Kondisi dimana kedalaman operation valve pada kedalaman 3922 ft. Sedangkan, desain software pipesim memperoleh 3 unloading valve dan 1 operating valve pada kedalaman 3088 ft. Perbedaan desain tersebut disebabkan karena adanya perbedaan penggunaan parameter pressure traverse desain spreadsheet dengan parameter desain pipesim yang lebih akurat, seperti nilai water cut, nilai laju alir liquid, nilai specific gravity oil sumur.
ESTUDO ANATÔMICO DAS LESÕES DE ENDOCARDIOSE EM CÃES, PREVALÊNCIA E EPIDEMIOLOGIA
Authors: Dobler Guilherme Hammarstrom , De Oliveira Heitor Scholl , Almeida Maxwell Richard
Published: June 2023

O coração é composto por duas importantes valvas átrio-ventriculares, a tricúspide e a bicúspide ou mitral. As válvulas cardíacas asseguram o sentido do fluxo sanguíneo dos átrios para os ventrículos e destes para as artérias. A endocardiose é um processo degenerativo crônico progressivo das válvulas, que acomete especialmente os cães, denominada endocardiose ou “doença do cão velho”. Embora qualquer das válvulas possa ser afetada, é a válvula mitral que é habitualmente envolvida, isoladamente ou em combinação com a válvula tricúspide. A sua prevalência tem sido associada a parâmetros como idade, sexo e raça, afetando especialmente animais adultos de raças de pequeno porte. A etiologia da endocardiose é desconhecida, mas parece haver uma base hereditária. As lesões macroscópicas iniciais consistem em pequenos nódulos nas margens livres da valva, ficando distorcidas e com suas dimensões reduzidas, mas significativamente espessas e de coloração opaca, branca ou reluzente. Microscopicamente, a endocardiose é vista como um processo degenerativo do tecido valvular com discreta infiltração de tecido conjuntivo fibroso. Em estágios iniciais a doença apresenta, à auscultação, murmúrios cardíacos de baixa intensidade, sem sinais de descompensação e é geralmente achado incidental durante a rotina de exame clínico. As cúspides fundem-se em sua inserção, mas separam-se em direção ao centro da abertura, ajustando-se estreitamente ao mesmo tempo quando a valva se fecha e suas bordas livres são espessas e irregulares, especialmente durante uma fase tardia da vida. Com isso, o objetivo do presente trabalho foi averiguar as principais lesões, a epidemiologia e o grau de prevalência da endocardiose em cães na região noroeste do estado do Rio Grande do Sul, o que se verificou que não há casos frequentes na rotina clínica de pequenos animais de endocardiose. Não sendo possível verificar se há um sexo mais predisposto a apresentar a endocardiose. As lesões observadas na macroscopia eram referentes a nódulos brilhantes, e na microscopia presença de colágeno causando o espessamento da cúspide, além de achados inflamatórios.
Form Exploration with Gist Method A Case Study of Product Design
Authors: Gumulya Devanny , Sutantio Handoko
Published: June 2023

To be successful in today’s competitive market, businesses must have a clear product recognition among their users. Consumers frequently have a wide range of products to choose from, making it difficult for a company’s products to be discovered and remembered. An important factor is product recognition and how we perceive it through our perception, which is primarily an identification process that is based on familiarity, resemblance, or similarity. Product gist is a technique used by product designers to visually evaluate product forms during the design process. The study employs an exploratory qualitative approach with multiple case studies in three design projects. The findings confirm that the gist method can assist product designers in creating strong product recognition. The gist method assists designers in identifying key representations that can be kept, modified, or eliminated in order to create new product recognition through typological innovation.

Keywordsgist method, product design, product recognition
Determining the Relationship between Surgical Anxiety Level, Type A Personality and Health Literacy
Authors: Hançer Ayşe , Demir Pervin , Kurtaran Deniz
Published: June 2023

Although it has been emphasised for many years that there is a Type A personality that has negative effects on health, contrary to popular belief, this has been rejected in recent studies. The effect of Type A personality on health literacy and on surgical anxiety level is a matter of curiosity. This study aimed to determine the relationship between surgical anxiety level, Type A personality and health literacy. The method used was a descriptive cross-sectional study with 250 patients. The total score averages of the patients’ Type A personality, surgical anxiety, and health literacy were determined as 74.50±22.51, 42.80±13.61, and 85.48±17.19, respectively. There was a positive moderately significant relationship between Type A personality and surgical anxiety, and a weakly significant positive relationship between Type A personality and health literacy. It was determined that there was a weak and negative correlation between health literacy and surgical anxiety. This study is possibly the first to reveal the relationship between surgical anxiety level, Type A personality and health literacy. Type A personality and health literacy were evaluated as two parameters that affect surgical anxiety level. Although the patients’ personality is not critical for surgery, it can significantly affect their treatment adherence later on. In the preoperative period, determining the patients’ personality characteristics and health literacy, and providing appropriate training and information under the leadership of health professionals, may be effective in reducing their surgical anxiety level.
Application of chromato-mass spectrometry to determine the acid composition of transformer oil
Authors:   Novosibirsk State Technical University, Lyutikova M. N. , Korobeynikov S. M. ,   Novosibirsk State Technical University, Ridel A. V. ,   Novosibirsk State Technical University
Published: June 2023

This article presents the results of a study of the acid composition of transformer oil from high-voltage transformers that have been in operation for more than 30 years. The acid composition of oils is studied using a new technique based on a highly sensitive and highly selective analysis method — chromato-mass spectrometry. The technique makes it possible to determine the acid composition of the insulating oil in the context of low molecular weight acids (LMA), high molecular weight acids (HMA) and phenolic compounds (PC). The structure of some compounds identified in oil is given. It has been established that during oil aging, among the acid compounds, the following are predominantly formed: HMA (60–95 %) > PC (3–16 %) > LMA (1–6 %). As part of the research, it is found that the share of the most dangerous low molecular weight acids in the total amount of acidic compounds is no more than 12 %. The rest of the acidity of the oil is due to the presence of macromolecular and phenolic compounds, which do not adversely affect the insulating properties of oil and paper in the detected concentrations, and some of them (compounds of a phenolic nature), on the contrary, even improve the stability against oxidation. These extended tests of oil samples from operating high-voltage equipment are of practical value in preventive diagnostics of the condition of its insulation.
Solution of the inverse problem of modified cyclographic model
Authors:   Omsk State Technical University, Lyubchinov E. V. , Panchuk K. L. ,   Omsk State Technical University, Myasoedova T. M. ,   Omsk State Technical University
Published: June 2023

In cyclographic modeling of a line of three-dimensional space, direct and inverse problems are known. A sufficient number of publications are devoted to the solution of these problems in the scientific literature. The authors of the work, on the basis of studies of the well-known classical cyclographic model, obtained its modification, called the modified cyclographic model. The need for this model caused by the solution of a number of practical problems of geometric modeling, in particular in the field of developing surface forms of roads, where traditionally only the direct problem of geometric modeling is considered, in which it is required to determine the surface shape of the latter along the spatial axis of the road. The authors proposed a solution to the inverse problem of modeling for a modified cyclographic projection, which makes it possible to restore a curved line of space from its cyclographic image. The paper gives a justification and a solution to the inverse problem of cyclographic modeling, implemented on a numerical example. The results of the work can be used in computer-aided design systems that specialize in the design of general and special roads.
Modification of metal-cutting plates from tungsten-free hard alloy grade KNT16 by continuous ion beams
Authors:   Omsk State Technical University, Badamshin A. M. , Povoroznuyk S. N. ,   Omsk State Technical University, Akimov V. V. ,   Siberian State Automobile and Highway University, Rogachev E. A. ,   Omsk State Technical University, Krutko A. A. ,   Omsk State Technical University
Published: June 2023

This work is devoted to the problem of developing technological operations aimed at improving the structure and properties and, as a result expanding the scope of metalcutting inserts from tungsten-free hard alloys. The search for alternative analogues of traditional tungsten-cobalt hard alloys is an urgent task of modern materials science, due to the high cost and shortage of their components. In this paper, we study the effect of a continius ion beam on the change in the morphology, mechanical properties, and performance characteristics of metal-cutting inserts made of tungsten-free hard alloy grade KNT16 (TiCN-NiMo). It has been found that the effect of continuous ion beams leads to a significant change in the wear resistance of cutting plates during turning operations on mediumcarbon steel 40KhN. A rational composition of the ion beam has been established, in which the cutting plate is subjected to the least wear after completion of the test cycle. Using the methods of scanning electron microscopy and scanning probe microscopy, a study of the microrelief and morphology of the surface of the samples is carried out.
Methodology for finding parameters of cutting transitions in APQP process of preproduction of new automotive components
Authors:   Naberezhnye Chelny Institute (branch) Kazan (Volga Region) Federal University, Safarova L. R. , Kasyanov S. V. ,   Naberezhnye Chelny Institute (branch) Kazan (Volga Region) Federal University, Safarov D. T. ,   Naberezhnye Chelny Institute (branch) Kazan (Volga Region) Federal University
Published: June 2023

The article discusses the content of the methodology for assessing the technological state of the machine tool system based on the method of planning experiments for cutting pre-designed and manufactured for special precision characteristics of automotive components of product samples. Using the example of an internal landing hole, the finding of diagnostic components of a special characteristic that are the result of the action of preknown technological factors is considered. Their finding is designed for the use of both shop and coordinate measuring instruments. The obtained regression models of diagnostic components make it possible at various stages of the APQP process to determine the intervals of the cutting process parameters that provide a predetermined margin of accuracy of a special characteristic, or to conclude that the accuracy of the machine system is inadequate. The application of the methodology together with statistical methods of quality management allows to ensure the maximum achievable level of stability of special characteristics in cutting operations, starting with the release of the first serial samples of products. The methodology can be used when selecting and evaluating the technological accuracy of newly purchased equipment in the APQP process of preparing the production of a new automotive component, acceptance of existing equipment after modernization or repair, as well as the audit of the technological process by the auditors of the supplier.
Dynamic rationing using agent-based modeling of the assembly process of equipment for nuclear power plants
Authors:   Joint Company «Research and Production Corporation «Space Monitoring Systems, Information & Control and Electromechanical», Loskutov I. A. , Skvortsova D. A. ,   Bauman Moscow State Technical University (National Research University), Iskandarova V. G. ,   MMZ Avangard
Published: June 2023

The work is raised as an agent-based model designed to calculate the time spent on the assembly stage of the manufacturing process for manufacturing equipment for nuclear power plants. The article focuses on the need for development, states the justification for research and development of the field of nuclear energy, with repeated facts. The paper uses various approaches to accounting for labor productivity. The concept of a gradual increase in employee fatigue for the development of the technical process is taken as the base. The agents of the model contain the workers and the technological process. The components of programs implemented in the C# language are shown, descriptions of classes are described, their actions to simulate the behavior of agents of a production system. The class diagram shows the selected classes and the relationships between them in terms of inheritance. There is a study of the use of models of a typical assembly process — the assembly of a cabinet frame, consisting of seven main operations. The paper presents structured, empirically analyzed values of fatigue categories and process time for 85 employees in graphical form by operations. It shows an example of an increase in fatigue for one of the employees and a Gantt chart, which can be used to evaluate how the operations went over time. As the output of the agent-based model, the calculated value of the time spent for the entire stage of the technological process of assembling equipment for nuclear power plants is provided. The accuracy of calculations of data convergence, income on the environment in Matlab Mathworks and Microsoft Excel during manual modeling is argued. The agreements state a slight deviation from the data model of the developed agent-based model of a practical experiment carried out as part of the implementation of the contract for the creation of equipment for a new power unit, a causal analysis is carried out. Also, in the applications, exceptional values of some performance indicators are analyzed and attention is focused on the unjustification of classical average approaches in the analysis of overall performance, using several examples. Information is given on the application of the agent model in possible options.
Calculation of additional shunt for current sensor of insulators
Authors:   Omsk State Technical University, Tereshchenko N. A. , Nikitin K. I. ,   Omsk State Technical University, Kholmov M. A. ,   Omsk State Technical University, Novoselov V. I. ,   Tobolsk Industrial Institute (branch)
Published: June 2023

The purpose of the study is to review the existing devices and methods for diagnosing and monitoring the state of high-voltage insulation, which plays an important role in the criteria for the reliability of the power system. One of the main methods for diagnosing insulators is a visual inspection. At the moment, online methods have become widespread, allowing to fix the process of destruction of insulation under voltage. Despite the existence of various methods and devices, the problem of timely detection of insulation deterioration in the operating mode has not been solved at the moment. This problem is solved by using an additional shunt design. When the task is achieved, the method of calculating the strength analysis of the additional shunt is used, and the simulation of this process is performed in the ANSYS program. Mechanical strength sufficient for operation under voltage. Experimental tests are carried out with the developed sample of the shunt. As a result of the study, a number of experiments are carried out with this design of the shunt, which have confirmed its performance. Due to the presence of the shunt, it is possible to fix leakage currents of the order of several tens of microamperes. Thus, the authors have proposed the current sensor, which is made in the form of an additional resistive shunt.