bluuebunny/crossref_metadata_2025 huggingface dataset:
Affect, Body, and Eating Habits in Children: A Systematic Review
Authors: Abdoli Marzieh , Scotto Rosato Marco , Cipriano Annarosa , Napolano Rosanna , Cotrufo Paolo , Barberis Nadia , Cella Stefania
Published: July 2023

The present review investigates the complex associations between children’s affective states, body perceptions, and eating habits, thus providing crucial insights for potential health interventions. Following PRISMA guidelines, three databases were searched for peer-reviewed studies exploring the relationship between eating habits, emotional states, and body image perceptions in a population of children (5 to 11 years old). A total of seven articles were included. Our findings revealed a pattern of associations between negative emotional states, like anxiety and depressive feelings, and maladaptive eating behaviors. Additionally, explicit influences from parental feeding practices, peer pressure, socioeconomic factors, and children’s body perceptions were observed to shape eating habits, with a pronounced tendency among older girls towards dieting and food preoccupation. Our results underline the intertwining nature of age, gender, and emotional states. Furthermore, our findings accentuate the urgency for comprehensive interventions that acknowledge and address the complex interplay of emotional, familial, and socioeconomic factors alongside children’s body image perceptions. The criticality of continued research, particularly ones employing longitudinal designs and diverse demographic samples, is highlighted as we strive to understand and navigate such multifaceted relationships to enhance children’s health and well-being.
Influence of Nutrition and Physical Activity on Local and Systemic Inflammatory Signs in Experimentally Induced Gingivitis
Authors: Staufenbiel Ingmar , Adam Knut , Hahn Andreas , Kerlikowsky Felix , Flohr Marco , Schlueter Nadine , Vach Kirstin
Published: July 2023

Although numerous studies have been published investigating the relationship between various dietary components and inflammatory periodontal disease, it has not yet been possible to clearly distinguish between periodontally healthy and unhealthy diets. This clinical study aimed to assess the association of specific food ingredients and physical activity on local and systemic inflammatory signs in experimentally induced gingivitis. Thirty-nine non-smoking periodontally healthy volunteers (mean age 23.2 ± 3.8 years) refrained from oral hygiene in the right maxilla for 21 days to induce an experimental gingivitis. Clinical examination (baseline and day 21) included plaque index, bleeding on probing (BOP), gingival crevicular fluid volume and high sensitive C-reactive protein levels (blood sample). Accompanying the intervention, volunteers documented with validated questionnaires their physical activity converted into metabolic equivalent (MET) and their nutrition converted into the dietary inflammatory index (DII). Significantly lower BOP (p = 0.039) was found for subjects with a more anti-inflammatory DII than for those with a more pro-inflammatory DII; higher MET values were correlated with lower BOP at day 21 (correlation coefficient −0.36). The results show an influence of nutrition and physical activity on periodontal inflammation signs. The DII may be a suitable parameter to verify the relationship between nutrition and inflammatory periodontal diseases.
Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease
Authors: Divyajanani Srinivasaragavan , Harithpriya Kannan , Ganesan Kumar , Ramkumar Kunka Mohanram
Published: July 2023

The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in regulating cellular homeostasis and apoptosis. The NRF2 gene has been implicated in various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. NRF2 can be regulated genetically and epigenetically at the transcriptional, post-transcriptional, and translational levels. Although DNA methylation is one of the critical biological processes vital for gene expression, sometimes, anomalous methylation patterns result in the dysregulation of genes and consequent diseases and disorders. Several studies have reported promoter hypermethylation downregulated NRF2 expression and its downstream targets. In contrast to the unalterable nature of genetic patterns, epigenetic changes can be reversed, opening up new possibilities in developing therapies for various metabolic disorders and diseases. This review discusses the current state of the NRF2-mediated antioxidative and chemopreventive activities of several natural phytochemicals, including sulforaphane, resveratrol, curcumin, luteolin, corosolic acid, apigenin, and most other compounds that have been found to activate NRF2. This epigenetic reversal of hypermethylated NRF2 states provides new opportunities for research into dietary phytochemistry that affects the human epigenome and the possibility for cutting-edge approaches to target NRF2-mediated signaling to prevent chronic disorders.
Effects of School-Based Health-Promoting Activities on Children’s Health: A Pragmatic Real-World Study
Authors: Hahnraths Marla T. H. , Winkens Bjorn , van Schayck Onno C. P.
Published: July 2023

More insight into the health effects of scaled-up school-based interventions in real-world settings is vital to sustainably integrate health in all schools. This study investigated the effectiveness of the scaled-up Healthy Primary School of the Future (HPSF) initiative in real-world school contexts on children’s health (behaviours). From 2019 to 2022, eleven Dutch primary schools implemented HPSF-related activities. In 315 children from study years four to six (aged 7–11 years) from these schools, anthropometric measurements were performed, and questionnaires assessing the children’s dietary behaviours and physical activity were administered. COVID-19 greatly limited the implementation of HPSF-related activities. Therefore, the results were compared between schools categorised as medium implementers and schools categorised as low implementers. After correction for baseline, waist circumference in the medium implementer group was significantly higher at one-year follow-up (B = 1.089, p = 0.003) and two-year follow-up (B = 1.665, p < 0.001) compared with waist circumference in the low implementer group. No significant effects were observed for other outcomes. This study showed hardly any effects of the scaled-up HPSF initiative, mainly due to the limited implementation caused by COVID-19. More research investigating the real-world effectiveness of HPSF and comparable programmes is greatly encouraged to advance the field of school-based health promotion.
You Are What You Eat: A Review on Dietary Interventions for Treating Pediatric Nonalcoholic Fatty Liver Disease
Authors: Sandel Piper , Ma Lawrence , Wang Helen , Pasman Eric A.
Published: July 2023

As the obesity pandemic worsens, cases of pediatric nonalcoholic fatty liver disease (NAFLD) and complications of this disease, such as progressive liver failure, in young adults will continue to rise. Lifestyle changes in the form of dietary modifications and exercise are currently first-line treatments. Large pediatric-specific randomized controlled trials to support specific interventions are currently lacking. A variety of dietary modifications in children with NAFLD have been suggested and studied with mixed results, including low-sugar and high-protein diets, the Mediterranean diet, and the Dietary Approach to Stop Hypertension (DASH). The roles of dietary supplements such as Vitamin E, polyunsaturated fatty acids (PUFAs), ginger, and probiotics have also been investigated. A further understanding of specific dietary interventions and supplements is needed to provide both generalizable and sustainable dietary recommendations to reverse the progression of NAFLD in the pediatric population.
The Metabolic and Analytical Changes of Healthy Volunteers upon Intake of Portuguese Extra Virgin Olive Oil: A Comparison Study between Pre- and Post-Intervention
Authors: Correia Marta , Moreira Inês , El Maghariki Jane , Manuel Tânia , Alves Paulo , Barros Rui , Gomes Ana
Published: July 2023

(1) Background: Extra virgin olive oil (EVOO) is studied mostly for its health benefits in preventing non-communicable chronic diseases, particularly within a Mediterranean dietary pattern. However, few studies have addressed the effect of EVOO in healthy individuals, prior to an established disease. This study aims to evaluate the impact of Northern Portuguese polyphenol-rich EVOO (NPPR-EVOO) consumption on various important clinical parameters in healthy adult volunteers. (2) Methods: This quasi-experimental intervention study assessed the impact of NPPR-EVOO for a period of 100 days. Serum total cholesterol, HbA1c, HDL-c, LDL-c, and CRP, and anthropometric measures—waist and hip perimeters, hand grip strength, and body fat—were assessed and food logs were analyzed. (3) Results: Serum HbA1c (5.12 ± 0.32%; 4.93 ± 0.24, p = 0.000) and LDL-c (96.50 ± 28.57 mg/dL; 87.41 ± 31.38 mg/dL, p = 0.017) significantly decreased following NPPR-EVOO. Also, daily energy significantly increased, but no changes in other dietary parameters, or anthropometry, were seen. Adherence to the Mediterranean diet did not explain the differences found in individuals regarding serum lipid profile and HbA1c, reinforcing the role of EVOO’s effect. (4) Conclusions: NPPR-EVOO lowered the serum levels of LDL cholesterol and HbA1c, providing clues on the effect of EVOO-putative health benefits. These results pave the way for a deeper exploration of EVOO as a functional food.
How the Gus Schumacher Produce Prescription Program Works: An Adaptation of a Nutrition Incentive Theory of Change
Authors: Stotz Sarah A. , Nugent Nadine Budd , Akers Melissa , Leng Kirsten , Byker Shanks Carmen , Yaroch Amy L. , Krieger James , Szczepaniak Morgan , Seligman Hilary
Published: July 2023

The United States Department of Agriculture’s Gus Schumacher Nutrition Incentive Program (GusNIP) supports nutrition incentive (NI) and produce prescription programs (PPRs). PPRs allow healthcare providers to “prescribe” fruits and vegetables (FVs) to patients experiencing low income and/or chronic disease(s) and who screen positive for food insecurity. We developed a Theory of Change (TOC) that summarizes how and why PPRs work, identifies what the programs hope to achieve, and elucidates the causal pathways necessary to achieve their goals. We created the PPR TOC through an iterative, participatory process that adapted our previously developed GusNIP NI TOC. The participatory process involved food and nutrition security experts, healthcare providers, PPR implementors, and PPR evaluators reviewing the existing NI TOC and suggesting modifications to accurately reflect PPRs. The resulting TOC describes the mechanisms, assumptions, rationale, and underpinnings that lead to successful and equitable outcomes. Modifications of the NI TOC centered around equity and focused on inclusion of healthcare as an additional partner and the importance of health and healthcare utilization as outcomes. The TOC describes how the GusNIP PPR program reaches its goals. This understanding will be useful for PPR developers, implementers, funders, and evaluators for describing the pathways, assumptions, and foundations of successful PPRs.
The Relationship between Knowledge, Dietary Supplementation, and Sleep Quality in Young Adults after the COVID-19 Pandemic
Authors: Pokarowski Maciej , Kedra Michal , Piwinska Justyna , Kurek Katarzyna , Szczygiel Karolina , Denysiuk Piotr , Popiolek-Kalisz Joanna
Published: July 2023

Introduction: Sleep is one of the most important factors affecting the quality of life. More than 50% of Polish adults have sleeping disorders, and young adults are the ones particularly vulnerable to this. This is why the analysis of the predictors of sleep quality, such as sleep hygiene knowledge and dietary knowledge, in young adults is a very important topic, especially after the COVID-19 pandemic, which may have affected sleeping habits. Material and Methods: 402 young adults (mean age 28.12 ± 6.08 years old) were enrolled in the study during the COVID-19 pandemic. Sleep quality was assessed with the Pittsburgh Sleep Quality Questionnaire, while dietary knowledge and sleep hygiene knowledge were assessed with dedicated questionnaires. The participants were also asked about the use of specific dietary supplements. Results: The analysis showed that sleep hygiene knowledge was significantly associated with sleep length (R = −0.17, p = 0.003) and overall sleep quality (R = −0.17, p = 0.005), while dietary knowledge significantly correlated with time to fall asleep (R = −0.12, p = 0.026). The regression analysis revealed that sleep hygiene knowledge was a significant negative predictor of sleep quality impairment (β = −0.13, p = 0.028). Significant results were also obtained for the use of supplements (β = −0.20; p = 0.001) and the use of medications (β = −0.32, p = 0.001), which were negative predictors of sleep quality impairment. Conclusions: This study showed that increased sleep hygiene knowledge promoted improved sleep length and overall sleep quality. In addition, dietary knowledge significantly correlated with time to fall asleep. On the other hand, decreased sleep quality was observed in participants who used medications or dietary supplements.
Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating
Authors: Kara Aytug , Kumar Dinesh , Healy Anne Marie , Lalatsa Aikaterini , Serrano Dolores R.
Published: July 2023

Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components. Particle size and morphology control are key quality attributes for cocrystal medicinal products. The needle-shaped morphology is often considered high-risk and complex in the manufacture of solid dosage forms. Cocrystal particle engineering requires advanced methodologies to ensure high-purity cocrystals with improved solubility and bioavailability and with optimal crystal habit for industrial manufacturing. In this study, 3D-printed microfluidic chips were used to control the cocrystal habit and polymorphism of the sulfadimidine (SDM): 4-aminosalicylic acid (4ASA) cocrystal. The addition of PVP in the aqueous phase during mixing resulted in a high-purity cocrystal (with no traces of the individual components), while it also inhibited the growth of needle-shaped crystals. When mixtures were prepared at the macroscale, PVP was not able to control the crystal habit and impurities of individual mixture components remained, indicating that the microfluidic device allowed for a more homogenous and rapid mixing process controlled by the flow rate and the high surface-to-volume ratios of the microchannels. Continuous manufacturing of SDM:4ASA cocrystals coated on beads was successfully implemented when the microfluidic chip was connected in line to a fluidized bed, allowing cocrystal formulation generation by mixing, coating, and drying in a single step.
Neuroprotective Impact of Linagliptin against Cadmium-Induced Cognitive Impairment and Neuropathological Aberrations: Targeting SIRT1/Nrf2 Axis, Apoptosis, and Autophagy
Authors: Arab Hany H. , Eid Ahmed H. , Alsufyani Shuruq E. , Ashour Ahmed M. , El-Sheikh Azza A. K. , Darwish Hany W. , Georgy Gehan S.
Published: July 2023

Cadmium is an environmental contaminant associated with marked neurotoxicity and cognitive impairment. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, has demonstrated promising neuroprotection against cerebral ischemia and diabetic dementia. However, there has been no study of its effect on cadmium-induced cognitive deficits. In the present work, linagliptin’s prospective neuroprotective effects against cadmium-evoked cognitive decline were examined in vivo in rats. The molecular pathways related to oxidative stress, apoptosis, and autophagy were investigated. Histology, immunohistochemistry, ELISA, and biochemical assays were performed on brain hippocampi after receiving linagliptin (5 mg/kg/day). The current findings revealed that cadmium-induced learning and memory impairment were improved by linagliptin as seen in the Morris water maze, Y-maze, and novel object recognition test. Moreover, linagliptin lowered hippocampal neurodegeneration as seen in histopathology. At the molecular level, linagliptin curtailed hippocampal DPP-4 and augmented GLP-1 levels, triggering dampening of the hippocampal neurotoxic signals Aβ42 and p-tau in rats. Meanwhile, it enhanced hippocampal acetylcholine and GABA and diminished the glutamate spike. The behavioral recovery was associated with dampening of the hippocampal pro-oxidant response alongside SIRT1/Nrf2/HO-1 axis stimulation. Meanwhile, linagliptin counteracted hippocampal apoptosis markers and inhibited the pro-apoptotic kinase GSK-3β. In tandem, linagliptin activated hippocampal autophagy by lowering SQSTM-1/p62 accumulation, upregulating Beclin 1, and stimulating AMPK/mTOR pathway. In conclusion, linagliptin’s antioxidant, antiapoptotic, and pro-autophagic properties advocated its promising neuroprotective impact. Thus, linagliptin may serve as a management approach against cadmium-induced cognitive deficits.
Novel Therapeutic Strategies in the Treatment of Systemic Sclerosis
Authors: Gumkowska-Sroka Olga , Kotyla Kacper , Mojs Ewa , Palka Klaudia , Kotyla Przemysław
Published: July 2023

Systemic sclerosis is a connective tissue disease of unknown origin and with an unpredictable course, with both cutaneous and internal organ manifestations. Despite the enormous progress in rheumatology and clinical immunology, the background of this disease is largely unknown, and no specific therapy exists. The therapeutic approach aims to treat and preserve the function of internal organs, and this approach is commonly referred to as organ-based treatment. However, in modern times, data from other branches of medicine may offer insight into how to treat disease-related complications, making it possible to find new drugs to treat this disease. In this review, we present therapeutic options aiming to stop the progression of fibrotic processes, restore the aberrant immune response, stop improper signalling from proinflammatory cytokines, and halt the production of disease-related autoantibodies.
Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)
Authors: Panova Ina G. , Tatikolov Alexander S.
Published: July 2023

The use of conventional contrast media for diagnostic purposes (in particular, Gd-containing and iodinated agents) causes a large number of complications, the most common of which is contrast-induced nephropathy. It has been shown that after exposure to contrast agents, oxidative stress often occurs in patients, especially in people suffering from various diseases. Antioxidants in the human body can diminish the pathological consequences of the use of contrast media by suppressing oxidative stress. This review considers the research studies on the role of antioxidants in preventing the negative consequences of the use of contrast agents in diagnostics (mainly contrast-induced nephropathy) and the clinical trials of different antioxidant drugs against contrast-induced nephropathy. Composite antioxidant/contrast systems as theranostic agents are also considered.
High-Performance Hybrid Phototheranostics for NIR-IIb Fluorescence Imaging and NIR-II-Excitable Photothermal Therapy
Authors: Wang Qi , Zhang Xinmin , Tang Youguang , Xiong Yanwei , Wang Xu , Li Chunlai , Xiao Tangxin , Lu Feng , Xu Mengze
Published: July 2023

Photothermal therapy operated in the second near-infrared (NIR-II, 1000–1700 nm) window and fluorescence imaging in the NIR-IIb (1500–1700 nm) region have become the most promising techniques in phototheranostics. Their combination enables simultaneous high-resolution optical imaging and deep-penetrating phototherapy, which is essential for high-performance phototheranostics. Herein, carboxyl-functionalized small organic photothermal molecules (Se-TC) and multi-layered NIR-IIb emissive rare-earth-doped nanoparticles (NaYF4:Yb,Er,Ce@NaYF4:Yb,Nd@NaYF4, RENP) were rationally designed and successfully synthesized. Then, high-performance hybrid phototheranostic nanoagents (Se-TC@RENP@F) were easily constructed through the coordination between Se-TC and RENP and followed by subsequent F127 encapsulation. The carboxyl groups of Se-TC can offer strong binding affinity towards rare-earth-doped nanoparticles, which help improving the stability of Se-TC@RENP@F. The multilayered structure of RENP largely enhance the NIR-IIb emission under 808 nm excitation. The obtained Se-TC@RENP@F exhibited high 1064 nm absorption (extinction coefficient: 24.7 L g−1 cm−1), large photothermal conversion efficiency (PCE, 36.9%), good NIR-IIb emission (peak: 1545 nm), as well as great photostability. Upon 1064 nm laser irradiation, high hyperthermia can be achieved to kill tumor cells efficiently. In addition, based on the excellent NIR-IIb emission of Se-TC@RENP@F, in vivo angiography and tumor detection can be realized. This work provides a distinguished paradigm for NIR-IIb-imaging-guided NIR-II photothermal therapy and establishes an artful strategy for high-performance phototheranostics.
Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review
Authors: Khalid Ramsha , Mahmood Syed , Mohamed Sofian Zarif , Hilles Ayah R. , Hashim Najihah Mohd , Ge Yi
Published: July 2023

One of the most cutting-edge, effective, and least invasive pharmaceutical innovations is the utilization of microneedles (MNs) for drug delivery, patient monitoring, diagnostics, medicine or vaccine delivery, and other medical procedures (e.g., intradermal vaccination, allergy testing, dermatology, and blood sampling). The MN-based system offers many advantages, such as minimal cost, high medical effectiveness, comparatively good safety, and painless drug application. Drug delivery through MNs can possibly be viewed as a viable instrument for various macromolecules (e.g., proteins, peptides, and nucleic acids) that are not efficiently administered through traditional approaches. This review article provides an overview of MN-based research in the transdermal delivery of hypertensive drugs. The critical attributes of microneedles are discussed, including the mechanism of drug release, pharmacokinetics, fabrication techniques, therapeutic applications, and upcoming challenges. Furthermore, the therapeutic perspective and improved bioavailability of hypertensive drugs that are poorly aqueous-soluble are also discussed. This focused review provides an overview of reported studies and the recent progress of MN-based delivery of hypertensive drugs, paving the way for future pharmaceutical uses. As MN-based drug administration bypasses first-pass metabolism and the high variability in drug plasma levels, it has grown significantly more important for systemic therapy. In conclusion, MN-based drug delivery of hypertensive drugs for increasing bioavailability and patient compliance could support a new trend of hypertensive drug delivery and provide an alternative option, overcoming the restrictions of the current dosage forms.
Therapeutic Salivary Monitoring of Perampanel in Patients with Epilepsy Using a Volumetric Absorptive Microsampling Technique
Authors: Palmisani Michela , Tartara Elena , Johannessen Landmark Cecilie , Crema Francesca , De Giorgis Valentina , Varesio Costanza , Fattore Cinzia , Rota Paola , Russo Emilio , Franco Valentina
Published: July 2023

The objective of this study was to validate a novel assay using the volumetric absorptive microsampling (VAMS) technique combined with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for the determination of the antiseizure medication perampanel in saliva and its clinical applicability in patients with epilepsy. VAMS tips were loaded with 30 μL of saliva and dried for 60 min. Analytes were extracted with methanol. The supernatant was evaporated under a gentle stream of nitrogen and reconstituted with 60 μL of methanol. Separation and quantification were achieved on a monolithic column connected to a mass spectrometer. Calibration curves were linear between 0.5 and 300 ng/mL. Intra- and inter-day accuracy was within 85.6–103.2% and intra-day and inter-day precision did not exceed 12.1%. Perampanel was stable in samples collected by VAMS and stored under different storage conditions. The VAMS-LC-MS/MS method was validated according to internationally accepted criteria and tested in patients with epilepsy who were receiving a combination of perampanel and other antiseizure medications. The method showed adequate bioanalytical performances, holding great potential as an alternative strategy to support domiciliary TDM in patients with epilepsy treated with perampanel according to the simplicity of sample collection.
SeDeM as a Tool to Validate Drug Substance Manufacturing Processes and Assess Scalability and Suitability for Direct Compression: Supplier Screening
Authors: Figuera-Figuera Alba , Suñé-Pou Marc , Pérez-Lozano Pilar , García-Montoya Encarna , Amela-Navarro Joaquim , Suñé-Negre Josep M.
Published: July 2023

During the development of an oral solid form of a drug substance, a thorough understanding of the critical material attributes is necessary, as the physical properties of the active pharmaceutical ingredient (API) can profoundly influence the drug product’s manufacturability, critical quality attributes, and bioavailability. The objective of this study was to validate the manufacturing process of the drug Linezolid from three different sources at both the pilot and industrial scale and to identify differences in critical material attributes between the API manufacturers. Furthermore, the scalability factor between the pilot and industrial scale and the suitability of a process for direct compression were also evaluated. In the present study, the different sources of API were characterized by SeDeM methodology, particle size distribution, and scanning electron microscopy determinations. The statistical analysis revealed that no statistically significant differences were found for any of the parameters under study for the same API source analyzed on both scales. On the other hand, for most of the parameters evaluated, statistical differences were observed between the different sources. It was concluded that SeDeM was able to successfully validate the API manufacturing process, assess scalability, and distinguish between sources. Therefore, it could be highly valuable in the formulation phase to select the best API source.
Progress in circRNA-Targeted Therapy in Experimental Parkinson’s Disease
Authors: Titze-de-Almeida Simoneide Souza , Titze-de-Almeida Ricardo
Published: July 2023

Circular RNAs (circRNAs) are single-stranded RNA molecules often circularized by backsplicing. Growing evidence implicates circRNAs in the underlying mechanisms of various diseases, such as Alzheimer’s and Parkinson’s disease (PD)—the first and second most prevalent neurodegenerative disorders. In this sense, circSNCA, circHIPK2, circHIPK3, and circSLC8A1 are circRNAs that have been related to the neurodegenerative process of PD. Gain-of-function and loss-of-function studies on circRNAs have shed light on their roles in the pathobiology of various diseases. Gain-of-function approaches typically employ viral or non-viral vectors that hyperexpress RNA sequences capable of circularizing to form the specific circRNA under investigation. In contrast, loss-of-function studies utilize CRISPR/Cas systems, antisense oligonucleotides (ASOs), or RNAi techniques to knock down the target circRNA. The role of aberrantly expressed circRNAs in brain pathology has raised a critical question: could circRNAs serve as viable targets for neuroprotective treatments? Translating any oligonucleotide-based therapy, including those targeting circRNAs, involves developing adequate brain delivery systems, minimizing off-target effects, and addressing the high costs of treatment. Nonetheless, RNAi-based FDA-approved drugs have entered the market, and circRNAs have attracted significant attention and investment from major pharmaceutical companies. Spanning from bench to bedside, circRNAs present a vast opportunity in biotechnology for oligonucleotide-based therapies designed to slow or even halt the progression of neurodegenerative diseases.
Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles
Authors: Manta Konstantina , Papakyriakopoulou Paraskevi , Nikolidaki Anna , Balafas Evangelos , Kostomitsopoulos Nikolaos , Banella Sabrina , Colombo Gaia , Valsami Georgia
Published: July 2023

Quercetin (Que) is one of the most studied flavonoids with strong antioxidant properties ascribed to its ability to bind free radicals and inactivate them. However, the low solubility of the compound along with its inadequate absorption after oral administration limit its beneficial effects. Que’s complexation with two different cyclodextrin (CD) derivatives (hydroxypropyl-β-CD and methyl-β-CD) via the neutralization/lyophilization method has been found to improve its physicochemical properties. Moreover, blends of the lyophilized powders with mannitol/lecithin microparticles (MLMPs) have been proposed as candidates for intranasal (IN) administration after in vitro and ex vivo evaluations. In this context, a comparative pharmacokinetic (PK) study of the IN vs oral administration of Que lyophilized powders and their blends with MLMPs (75:25 w/w) was performed on Wistar rats. The PK parameters estimated by a non-compartmental analysis using the sparse data methodology in Phoenix® 8.3 (Certara, Princeton, NJ, USA) illustrated the effectiveness of IN administration either in brain targeting or in reaching the bloodstream. Significant levels of the compound were achieved at both sites, compared to those after oral delivery which were negligible. These results favor the potential application of the prepared Que nasal powders for systemic and nose-to-brain delivery for the prevention and/or treatment of neuroinflammatory degenerative conditions, such as Parkinson’s and Alzheimer’s disease.
Can Computational Intelligence Model Phenomenal Consciousness?
Authors: Garrido Merchán Eduardo , Lumbreras Sara
Published: July 2023

Consciousness and intelligence are properties that can be misunderstood as necessarily dependent. The term artificial intelligence and the kind of problems it managed to solve in recent years has been shown as an argument to establish that machines experience some sort of consciousness. Following Russell’s analogy, if a machine can do what a conscious human being does, the likelihood that the machine is conscious increases. However, the social implications of this analogy are catastrophic. Concretely, if rights are given to entities that can solve the kind of problems that a neurotypical person can, does the machine have potentially more rights than a person that has a disability? For example, the autistic syndrome disorder spectrum can make a person unable to solve the kind of problems that a machine solves. We believe the obvious answer is no, as problem-solving does not imply consciousness. Consequently, we will argue in this paper how phenomenal consciousness, at least, cannot be modeled by computational intelligence and why machines do not possess phenomenal consciousness, although they can potentially develop a higher computational intelligence than human beings. In order to do so, we try to formulate an objective measure of computational intelligence and study how it presents in human beings, animals, and machines. Analogously, we study phenomenal consciousness as a dichotomous variable and how it is distributed in humans, animals, and machines.
FP Interferometric Optic Fiber Humidity Sensor Based on Acrylate AB Adhesive Film
Authors: Wang Qiying , Zhang Fangfang , Zhang Mengfan , Zhang Kunpu , Zhang Yaqian , Wang Guanjun , Hu Zhuhua , Deng Qian
Published: July 2023

In this paper, an optical fiber humidity sensor based on acrylate AB adhesive film is studied, and two methods—a bubbling method and a dual pressure assisted method—for preparing thin films are proposed. The forms will make the thin film lighter and make the sensor more sensitive. Using a glass tube to connect the acrylate AB adhesive film to the single mode optical fiber, the humidity sensor is obtained. Through humidity response experiments, the sensor’s sensitivity reaches 167.5 pm/% RH, and the response time reaches 4.8 s/% RH. At the same time, the experiments show that the sensor has good repeatability and stability. Finally, the influence of temperature on the working process is analyzed, and we provide a method for improvement through FBG.
Unveiling the Significance of Correlations in K-Space and Configuration Space for Drift Wave Turbulence in Tokamaks
Authors: Weiland Jan , Rafiq Tariq , Schuster Eugenio
Published: July 2023

Turbulence and transport phenomena play a crucial role in the confinement and stability of tokamak plasmas. Turbulent fluctuations in certain physical quantities, such as density or temperature fluctuations, can have a wide range of spatial scales, and understanding their correlation length is important for predicting and controlling the behavior of the plasma. The correlation length in the radial direction is identified as the critical length in real space. The dynamics in real space are of significant interest because transport in configuration space is primarily focused on them. When investigating transport caused by the E×B drift, the correlation length in real space represents the size of E×B whirls. It was numerically discovered that in drift wave turbulence, this length is inversely proportional to the normalized mode number of the fastest growing mode relative to the drift frequency. Considerable time was required before a proper analytical derivation of this condition was accomplished. Therefore, a connection has been established between phenomena occurring in real space and those occurring in k-space. Although accompanied by a turbulent spectrum in k-space with a substantial width, transport in real space is uniquely determined by the correlation length, allowing for accurate transport calculations through the dynamics of a single mode. Naturally, the dynamics are subject to nonlinear effects, with resonance broadening in frequency being the most significant nonlinear effect. Thus, mode number space is once again involved. Resonance broadening leads to the detuning of waves from particles, permitting a fluid treatment. It should be emphasized that the consideration here involves the total electric field, including the induction part, which becomes particularly important at higher beta plasmas.
Effect of Reinforcement with Short Carbon Fibers on the Friction and Wear Resistance of Additively Manufactured PA12
Authors: Gadelmoula Abdelrasoul , Aldahash Saleh Ahmed
Published: July 2023

Reinforcing thermoplastic materials for additive manufacturing with either short, long, and continuous fibers or micro/nanoparticles is a sound means to enhance the mechanical/tribological properties of functional 3D printed objects. However, despite the fact that reinforced thermoplastics are being used extensively in modern applications, little data are found in open literature regarding the effect of such reinforcements on the friction and wear characteristics of additively manufactured objects. Therefore, this article presents a comparative study that aims to investigate the friction and wear behavior of carbon fiber-reinforced polyamide 12 (CF-PA12) as compared to pure polyamide 12 (PA12). The test specimens were prepared by selective laser sintering (SLS) at five different build orientations and examined using a pin-on-disc tribometer in dry sliding mode. The coefficient of friction (COF), interface temperature, friction-induced noise, and specific wear rate were measured. Scanning electron microscopy (SEM) was used to inspect the tribo-surfaces. The results revealed that both the COF and contact temperature of CF-PA12 are orientation-independent and are lower than those of pure PA12. Also, it was found that, compared with pure PA12, CF-PA12 has 25% smaller COF and 15–40% higher wear resistance. Further, the SEM of tribo-surfaces showed that adhesive wear dominates the surface of pure PA12, while both adhesive and abrasive wear patterns coexist in CF-PA12. Moreover, fiber crushing and thinning were observed, and this, under some circumstances, can result in a considerable increase in frictional noise.
Removal of the Water Pollutant Ciprofloxacin Using Biodegradable Sorbent Polymers Obtained from Polysaccharides
Authors: Alvarado Sarah , Megia-Fernandez Alicia , Ortega-Muñoz Mariano , Hernandez-Mateo Fernando , Lopez-Jaramillo F. Javier , Santoyo-Gonzalez Francisco
Published: July 2023

Water use has been increasing globally by 1% per year, and recycling and re-use are critical issues compromised by the presence of pollutants. In this context, the design of novel materials and/or procedures for the large scale-removal of pollutants must be economically and environmentally feasible in order to be considered as part of the solution by emerging economies. We demonstrate that the cross-linking of biodegradable polysaccharides such as starch, dextrin, or dextrin and β-cyclodextrin with divinyl sulfone is an innovative strategy for synthesizing insoluble and eco-friendly sorbent polymers, including pSt, pDx and pCD-Dx. The evaluation of these polymers’ ability to remove ciprofloxacin (CIP), a prime example of antibiotic pollution, revealed that pSt, with a Kd of 1469 L/kg and a removal rate higher than 92%, is a favorable material. Its sorption is pH-dependent and enhanced at a mildly alkaline pH, allowing for the desorption (i.e., cleaning) and reuse of pSt through an environmentally friendly treatment with 20 mM AcONa pH 4.6. The facts that pSt (i) shows a high affinity for CIP even at high NaCl concentrations, (ii) can be obtained from affordable starting materials, and (iii) is synthesized and regenerated through organic, solvent-free procedures make pSt a novel sustainable material for inland water and seawater remediation, especially in less developed countries, due to its simplicity and low cost.
Engineered Interleaved Random Glass Fiber Composites Using Additive Manufacturing: Effect of Mat Properties, Resin Chemistry, and Resin-Rich Layer Thickness
Authors: Ibrahim Ahmed M. H. , Idrees Mohanad , Tekerek Emine , Kontsos Antonios , Palmese Giuseppe R. , Alvarez Nicolas J.
Published: July 2023

Standard lay-up fabrication of fiber-reinforced composites (FRCs) suffer from poor out-of-plane properties and delamination resistance. While advanced manufacturing techniques (e.g., interleaving, braiding, and z-pinning) increase delamination resistance in FRCs, they typically result in significant fabrication complexity and limitations, increased manufacturing costs, and/or overall stiffness reduction. In this work, we demonstrate the use of facile digital light processing (DLP) technique to additively manufacture (AM) random glass FRCs with engineered interleaves. This work demonstrates how vat photo-polymerization techniques can be used to build composites layer-by-layer with controlled interleaf material, thickness, and placement. Note that this engineering control is almost impossible to achieve with traditional manufacturing techniques. A range of specimens were printed to measure the effect of interleaf thickness and material on tensile/flexural properties as well as fracture toughness. One important observation was the ≈60% increase in interlaminar fracture toughness achieved by using a tough resin material in the interleaf. The comparison between AM and traditionally manufactured specimens via vacuum-assisted resin transfer molding (VARTM) highlighted the limitation of AM techniques in achieving high mat consolidation. In other words, the volume fraction of AM parts is limited by the wet fiber mat process, and engineering solutions are discussed. Overall, this technique offers engineering control of FRC design and fabrication that is not available with traditional methods.
Valorization of Cellulose-Based Materials from Agricultural Waste: Comparison between Sugarcane Bagasse and Rice Straw
Authors: Thongsomboon Wiriya , Baimark Yodthong , Srihanam Prasong
Published: July 2023

Sugarcane bagasse and rice straw are major agricultural byproducts often discarded or burned as waste after cultivation, leaving their untapped potential for utilization. In this work, cellulose fibers were extracted from sugarcane bagasse and rice straw using a simple procedure: alkaline treatment with sodium hydroxide, bleaching with sodium hypochlorite, and acid hydrolysis. The obtained cellulosic materials were successfully prepared into milky white and transparent films, of which the transparency slightly decreased with the addition of glycerol. The surface of all the films appeared homogeneous with a random orientation of fibers. The rice-straw (RS) film had a more fragile texture than the sugarcane-bagasse (SBG) film. The FTIR analysis clearly indicated the functional groups of cellulose, as well as glycerol for the films mixed with glycerol. Thermal analysis showed that the native SBG film decomposed at 346 °C, higher than the native RS film (339 °C). The presence of glycerol in the films resulted in slightly lower maximum decomposition temperature (Td,max) values as well as mechanical properties. Regarding water susceptibility, the RS film had a higher percentage than the native SBG and glycerol-mixed SBG films. The extracted cellulose from both sources could form almost spherical-shaped cellulose particles. Thus, through the simple extraction method, sugarcane bagasse and rice straw could serve as excellent sources of cellulose materials for preparing cellulose films and particles, which would be advantageous to the development of cellulose-based materials.
Preparation and Characterization of Body-Temperature-Responsive Thermoset Shape Memory Polyurethane for Medical Applications
Authors: Yang Xiaoqing , Han Zhipeng , Jia Chengqi , Wang Tianjiao , Wang Xiaomeng , Hu Fanqi , Zhang Hui , Zhao Jun , Zhang Xuesong
Published: July 2023

Shape memory polymers (SMPs) are currently one of the most attractive smart materials expected to replace traditional shape memory alloys and ceramics (SMAs and SMCs, respectively) in some fields because of their unique properties of high deformability, low density, easy processing, and low cost. As one of the most popular SMPs, shape memory polyurethane (SMPU) has received extensive attention in the fields of biomedicine and smart textiles due to its biocompatibility and adjustable thermal transition temperature. However, its laborious synthesis, limitation to thermal response, poor conductivity, and low modulus limit its wider application. In this work, biocompatible poly(ε-caprolactone) diol (PCL-2OH) is used as the soft segment, isophorone diisocyanate (IPDI) is used as the hard segment, and glycerol (GL) is used as the crosslinking agent to prepare thermoset SMPU with a thermal transition temperature close to body temperature for convenient medical applications. The effects of different soft-chain molecular weights and crosslinking densities on the SMPU’s properties are studied. It is determined that the SMPU has the best comprehensive performance when the molar ratio of IPDI:PCL-2OH:GL is 2:1.5:0.33, which can trigger shape memory recovery at body temperature and maintain 450% recoverable strain. Such materials are excellent candidates for medical devices and can make great contributions to human health.
Study on the Biodegradation Process of D-Mannose Glycopolymers in Liquid Media and Soil
Authors: Pană Ana-Maria , Ordodi Valentin , Gherman Vasile , Sfîrloagă Paula , Dumitrel Gabriela-Alina
Published: July 2023

Polymers derived from natural raw materials have become of great interest due to their increased biodegradable features and possible biocompatibility. Our group has successfully synthesized and characterized polymers derived from D-mannose oligomer (M), 2-hydroxy propyl acrylate (HPA), and methacrylate (HPMA) in different weight ratios. Their biodegradation was studied in liquid media with pure Proteus mirabilis inoculum for the samples with the most sugar residue, and the results show that the methacrylate derivative M_HPMA1 lost about 50% of its weight during incubation. SEM/EDX techniques were employed to display the modifications of the samples during the biodegradation process. The glycopolymers were buried in garden soil, and the experiment proved that more than 40% of the weight of the M_HPA1 sample was lost during biodegradation, while the other samples encountered an average of about 32% weight loss. The biodegradation profile was fitted against linear and polynomial mathematical models, which enabled an estimate of about a year for the total degradation of the D-mannose glycopolymers sample in soil.
Poly(ionic liquid)/OPBI Composite Membrane with Excellent Chemical Stability for High-Temperature Proton Exchange Membrane
Authors: Xiao Yiming , Chen Haoran , Sun Ranxin , Zhang Lei , Xiang Jun , Cheng Penggao , Han Huaiyuan , Wang Songbo , Tang Na
Published: July 2023

Despite the outstanding proton conductivity of phosphoric acid (PA)-doped polybenzimidazole (PBI) membranes as high-temperature proton exchange membranes (HT-PEMs), chemical stability is a critical issue for the operation life of PEM fuel cells (PEMFCs). Herein, we introduced polymerized [HVIM]H2PO4 ionic liquids (PIL) into an OPBI membrane to accelerate proton transfer and enhance the chemical stability of the membrane. Based on the regulation of the intrinsic viscosity of PIL, the entanglement between PIL chains and OPBI chains is enhanced to prevent the loss of PIL and the oxidative degradation of membrane materials. The PIL/OPBI membrane with the intrinsic viscosity of 2.34 dL·g−1 (2.34-PIL/OPBI) exhibited the highest proton conductivity of 113.9 mS·cm−1 at 180 °C, which is 3.5 times that of the original OPBI membrane. The 2.34-PIL/OPBI membrane exhibited the highest remaining weight of 92.1% under harsh conditions (3 wt% H2O2; 4 ppm Fe2+ at 80 °C) for 96 h, and a much lower attenuation amplitude than the OPBI did in mechanical strength and proton conductivity performance. Our present work demonstrates a simple and effective method for blending PIL with OPBI to enhance the chemical durability of the PA-PBI membranes as HT-PEMs.
Editorial: Advance in Molecularly Imprinted Polymers
Authors: Cegłowski Michał
Published: July 2023

Molecularly imprinted polymers (MIPs), due to their unique recognition properties, have found various applications, mainly in extraction and separation techniques; however, their implementation in other research areas, such as sensor construction and drug delivery, has also been substantial [...]
Performance Study of Waste PE-Modified High-Grade Asphalt
Authors: Li Erda , Xu Wenyuan , Zhang Yang
Published: July 2023

In this work, waste polyethylene (PE)-modified 90# asphalt was made in order to investigate the performance of waste polyethylene-modified high-grade asphalt and the optimal blending quantity. Dynamic Shear Rheology (DSR) and Bending Beam Rheometer (BBR) tests were used to evaluate the high- and low-temperature performance of modified 90# PE-modified asphalt. Infrared spectroscopy and fluorescence microscopy were used to investigate the modification process and distribution status of waste PE in 90# asphalt. The DSR and BBR tests revealed that waste PE enhanced the high-temperature performance of 90# base asphalt and that 5% was the best blending rate. However, the change affects asphalt’s low-temperature performance, and the negative effect on asphalt’s low-temperature performance was minimized at 1% dosing. The incorporation of waste PE absorbed the light components of asphalt, while waste PE can form a reticulated structure in asphalt, which improves its high-temperature performance but degrades its low-temperature performance, according to the results of infrared spectroscopy and fluorescence microscopy.