bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of poor outcome in treatment of patients with pyoinflammatory otogenic and rinosinusogenic intracranial complications
Authors: Krivopalov A. A. , Janov Yu. K. , Shcherbuk A. Yu. , Shcherbuk Yu. A. , Rubin A. N. , Artyushkin S. A. , Shardanov Z. N.
Published: July 2019

OBJECTIVE. The authors would like to reveal preoperative and intraoperative predictors of lethal outcome in patients with otogenic and rhinosinusogenic pyoinflammatory intracranial complications. The study assessed an efficacy of specialized medical care of this category of patients. MATERIAL AND METHODS. Тhis research included 303 patients (199 (65,68 %) men and 104 (34,32 %) women) aged from 39,3 ± 17,4 years on average who underwent operation concerning intracranial pyoinflammatory oto- and rinosinusogenic complications in multidisciplinary hospitals of different subjects of the Russian Federation at the period from 2000 to 2014. RESULTS. Multiple logit regression analysis of predictors of lethal outcome showed the presence of higher number of factors and errors which influenced on treatment during preoperative period. These factors and errors caused an extension of preoperative period and increase of unfavorable outcome. CONCLUSIONS. While planning the management of primary and specialized care, doctors should take into account the identified predictors for patients of this category.
Antibodies to striated muscle and acetylcholine receptors in evaluation of surgical treatment outcomes in patients with autoimmune myasthenia gravis
Authors: Tovbina M. G. , Pishchik V. G. , Lapin S. V. , Nuraliev S. M.
Published: July 2019

OBJECTIVE. The authors evaluated the role of antibodies to striated muscle and acetylcholine receptors in diagnostics of myasthenia gravis and thymoma, as well as outcomes of thymectomy and prognosis of myasthenia course. MATERIAL AND METHODS. The study investigated correlations of antibody content to striated muscles and acetylcholine receptors from the presence and size of thymoma, myasthenia in 157 patients with various pathologies of the thymus. The dynamics of antibody concentrations was followed up after thymectomy. RESULTS. Antibody titer to striated muscle depended on the presence and size of thymoma, severity of myasthenia and changed after thymectomy. Concentration of antibodies was associated with the presence of thymoma and it didn’t change after surgical treatment. Thymoma wasn’t revealed in patients who were seronegative to both antibodies. CONCLUSIONS. Seropositivity according to one of antibody could indicate the presence of thymoma, but its absence to both antibodies allowed doctors to eliminate this diagnosis. Antibodies to acetylcholine receptors are important markers of myasthenia. Monitoring of antibody titer dynamics to striated muscles after thymectomy could be useful for assessment of response to surgical treatment and prognosis of course of myasthenia.
Pulmonary-pleural complications of pancreatitis
Authors: Kotel’Nikova L. P. , Plaksin S. A. , Kudryavtsev P. L. , Farshatova L. I.
Published: July 2019

OBJECTIVE. The authors investigated pulmonary-pleural complications of pancreatitis and evaluated results of CT examination in diagnostics and possibility of low invasive surgery in treatment of pancreaticogenic pleurisy. MATERIAL AND METHODS. A retrospective analysis was made of 156 medical histories of patients with acute pancreatitis and their results. An ultrasound examinations of the chest and CT scan were applied in order to determine lung tissue condition and presence of fluid in pleural cavities. RESULTS. The application of CT in diagnostics of pulmonary-pleural complications allowed doctors to identify an effusion in pleural cavities in 3,5-50 % patients with acute pancreatitis. The number and localization of effusions were defined more precisely. CONCLUSIONS. Mini-invasive procedures (puncture, videothoracoscopy) with examination of exudate on amylase activity and biopsy of pleura determined the causes of pleuritis. This was effective in pleritis elimination against a background of different methods of treatment of pancreatitis.
Experimental perfusion device for preservation of donor’s liver
Authors: Bagnenko S. F. , Reznik O. N. , Skvortsov A. E. , Lopota A. V. , Gryaznov N. A. , Kharlamov V. V. , Kireeva G. S.
Published: July 2019

OBJECTIVE. The authors aimed to develop complex perfusion medical device in order to successfully maintain viability of donor liver until transplantation. MATERIAL AND METHODS. Experimental perfusion device for normothermic perfusion donor’s liver was developed and tested in the Central Research and Experimental-design Institute of Robotics and Technical Cybernetics. RESULTS. The pre-clinical tests were performed on porcine liver. It was demonstrated that normothermic machine perfusion could restore liver function after 30 minutes of warm ischemia time and provide normalization of biochemical parameters of organ functioning.
Role of brachiocephalic arterial stenosis in development of postoperative complications after cardiosurgery
Authors: Tibekina L. M. , Smertina E. G. , Zolotov V. D. , Stolyarov M. S. , Kamenskikh M. S. , Shmatov D. V.
Published: July 2019

OBJECTIVE. The study investigated the role of stenosis of brachiocephalic arteries in development of postoperative complications in patients, who underwent the coronary bypass grafting (CABG) and operations concerning heart valve pathology in conditions of extracorporeal circulation. There were observed such complications as stroke (n = 4) and hypoxic ischemic encephalopathy with delirium in postoperative period. MATERIAL AND METHODS. The research was carried out in 21 patients on the base of Center of сardiosurgery and interventional cardiology of St. Petersburg Multifield Center. All the patients were male aged 64±6,9 years. RESULTS. The study showed that risk of cerebral complications, especially hypoxic ischemic encephalopathy with delirium, could increase in case of bilateral carotid stenosis combined with hemodynamically insignificant unilateral vertebral artery stenosis. The significant hemodynamic branchiocephalic arterial stenosis caused chronic and acute clinical signs of cerebrovascular insufficiency in anamnesis. CONCLUSIONS. The high risk of development of severe cerebral complications was associated with hemodynamically significant bilateral carotid stenosis accompanied by hemodynamically significant uni- and bilateral stenosis or one-sided occlusion of cerebral artery. Management of treatment should take into account risk factors of cardiosurgical patients.
Retroduodenal perforation as complication of endoscopic interventions in obstructive jaundice
Authors: Korolyov M. P. , Fedotov L. E. , Avanesyan R. G. , Ogloblin A. L. , Fedotov B. L.
Published: July 2019

OBJECTIVE. The research demonstrated possibilities of low invasive methods in treatment of retroduodenal perforations in patients with choledolithiasis complicated by obstructive jaundice. MATERIAL AND METHODS. Methods of treatment management were described in patients with retroduodenal perforation after endoscopic papillosphicterotomy and lithoextraction. RESULTS. The low invasive methods, which were described in this article, allowed doctors to cope with retroduodenal perforation without open surgical interventions. CONCLUSIONS. The choice of management strategy of patients with retroduodenal perforation depended on the time period, when it was revealed. Combined endoscopic and percutaneous methods could be successfully applied in treatment management of patients with retroduodenal perforation.
Fluorescence-guided resection of glioma using «photoditazin»
Authors: Rynda A. Yu. , Rostovtsev D. M. , Olyushin V. E. , Zabrodskaya Yu. M.
Published: July 2019

OBJECTIVE. The aim of this research was to improve results of gloss total resections of glial tumors of the brain. MATERIAL AND METHODS. Fluorescence-guided resection was performed in 31 patients with glial tumors of different degree of malignancy. «Photoditazin» was applied during operation. The authors assessed the efficacy, sensitivity and specificity of the method and degree of radical nature of resection in relation to surgery of gliomas. RESULTS. Sensitivity of the method numbered 68,3 % and specificity was 60,1 % in cases of gliomas of grade I-II. It was 85,4 % and 76,2 %, respectively in cases of gliomas of grade III-IV. The degree of achievement of gloss total resection (GTR) was 79,3 % (gliomas of grade III-IV) and 95,6 % (gliomas of grade III-IV). CONCLUSIONS. Intraoperative fluorescent diagnostics using «Photoditazin» was highly effective, sensitive and very specific method in surgery of glial tumors of different degree of malignancy. The method allowed doctors to develop the radical nature of surgery in cases of glial tumors removal.
New method of bimammary coronary artery bypass grafting through left-sided thoracotomy on working heart
Authors: Nemkov A. S. , Chzhan I. .. , Pizin V. M. , Belyi S. A. , Lukashenko V. I. , Dulaev A. V. , Bunenkov N. S. , Komok V. V. , Kobak A. E. , Babeshin M. V. , Morozov A. N. , Yashin S. M. , Grinenko O. A.
Published: July 2019

OBJECTIVE. The authors developed a low invasive method of bimammary coronary artery bypass grafting (CABG) of minimum two arteries through left-sided thoracotomy. MATERIAL AND METHODS. The left internal thoracic artery was used for bypass grafting of anterior interventricular artery according to V.I. Kolesov method. Anastomosis of the right interventricular artery with conduit (from autoartery or autovein) was performed by using extrapleural way in the second intercostal space from the right of the breast. Conduit was lengthened behind the sternum to pericardium cavity in order to create the second distal anastomosis with branch of coronary artery. RESULTS. The operations (10 cases) were conducted at the period from October 2015 to December 2016. The second distal anastomosis between conduit and coronary artery was performed with diagonal artery in 1 case, with branch of blunt edge in 5 cases and with posterior interventricular branch in 4 cases. Tolerance of operation and early postoperative period were satisfactory. CONCLUSIONS. New method of bimammary coronary artery bypass allowed doctors to perform revascularization minimum of two coronary vessels on working heart by avoiding manipulations on aorta and the sternum.
Uniportal video-assisted thoracoscopic lobectomies in lung cancer management
Authors: Arsen’Ev A. I. , Nefedov A. O. , Barchuk A. A. , Tarkov S. A. , Kostitsyn K. A. , Nefedova A. V.
Published: July 2019

OBJECTIVE. The study summarized personal surgical experience of uniportal video-assisted thoracoscopic (VATS) lobectomies for patients with stage I-II non-small cell lung cancer. MATERIAL AND METHODS. The authors have performed 72 VATS lobectomies for patients with stage I-II non-small lung cancer using modified minimally invasive single incision above anterior part of musculus latissimus dorsi. RESULTS. During the implementation period, there were carried out 2 (2,8 %) conversions to open thoracotomy. There weren’t observed lethal postoperative complications of VATS lobectomies. Other complications had 5 (6,9 %) patients. Postoperative pneumonia was in 1 (1,4 %) patient. Arrhytmia was noted in 4 (5,6 %) patients. The average operation time consisted of 227,4 min (from 60 to 460 min). Learning curve demonstrated a significant decrease of operation time with every following VATS lobectomy from 227,4 to 90,3 min (p=0,03). The quantity of removed regional lymph nodes estimated 14,2 ± 0,7 during uniportal VATS lobectomy. The median blood loss was 98,3 ml (from 10 to 300 ml). The average duration of air leak was 2,3 ± 0,65 days after uniportal VATS lobectomy. The mean term of drainage was 4,6 ± 0,53 days. CONCLUSIONS. The data obtained justified the feasibility, efficacy and safety of VATS lobectomies in patients with I-II stage of lung cancer.
Peculiarities of clinical manifestations of opisthorchosis papillitis
Authors: Onishchenko S. V. , Darvin V. V.
Published: July 2019

OBJECTIVE. The study identified peculiarities of clinical manifestations of opisthorchosis papillitis depending on the stage of disease. MATERIAL AND METHODS. Features of diagnostics were based on analysis of medical data of 384 patients with opisthorchosis papillitis. There were investigated and statistically processed 23 clinical signs, 9 laboratory indices and data of 9 methods of instrumental diagnostics. RESULTS. Generalized and isolated analyses of signs allowed doctors to determine their diagnostic significance. The instrumental methods of diagnostics gave an opportunity to reveal this pathology in contrast to data of clinical manifestations. The inner diameter of major duodenum papilla was used in order to determine the stage of opisthorchosis papillitis. CONCLUSIONS. Specific clinic-laboratory signs for papillitis indication weren’t found. The most preferable instrumental method of diagnostics appeared to be the endo-ultrasound investigation, which gave a possibility to visualize lumen and walls of papilla and perform a needle biopsy of its deep structures.
Risk factors of postoperative prolonged ileus after colorectal cancer surgery
Authors: Khomyakov E. A. , Rybakov E. G. , Zarodnyuk I. V. , Shelygin Yu. A. , Pikunov D. Yu.
Published: July 2019

OBJECTIVE. The authors identified independent risk factors of postoperative prolonged ileus after colorectal cancer surgery. MATERIAL AND METHODS. Multivariate logit regression analysis was made in order to reveal independent risk factors of prolonged ileus. RESULTS. The frequency of prolonged ileus cases consisted of 13 %. The authors detected three independent risk factors such as body mass index higher than 25 kg/m² (p=0,033), taking of opioid analgetics (p=0,022) and left colon flexure mobilization (p=0,047) in multivariate statistical analysis. CONCLUSIONS. Postoperative prolonged ileus was the frequent complication in colorectal cancer surgery. There is a possibility to identify the group of patients who exposed to risk of occurrence of prolonged postoperative ileus due to application of revealed risk factors.
Treatment management in opisthorchosis papillitis
Authors: Onishchenko S. V.
Published: July 2019

OBJECTIVE. The author designed an optimal treatment strategy in patients with opisthorchosis papillitis complicated by development of cholangitis. MATERIAL AND METHODS. Retrospective analysis of treatment results of 384 patients with opisthorchosis lesions of bile ducts was made. The patients were divided into randomized groups associated with applied surgical approaches. RESULTS. There was revealed an advantage of staged method of surgery performance. Practicability of application of minimally invasive and organ-saving methods was shown in initial stages of disease. Clinical version of classification of opisthorchosis papillitis were presented. СONCLUSIONS. Treatment management of patients with opisthorchosis papillitis should be based on the process stage and it should be maximally organ-saving.
Global optimization via neural network approximation of inverse coordinate mappings with evolutionary parameter control
Authors: Pushkaryov Kirill Vladimirovich
Published: July 2019

A hybrid method of global optimization NNAICM-PSO is presented. It uses neural network approximation of inverse mappings of objective function values to coordinates combined with particle swarm optimization to find the global minimum of a continuous objective function of multiple variables with bound constraints. The objective function is viewed as a black box.

The method employs groups of moving probe points attracted by goals like in particle swarm optimization. One of the possible goals is determined via mapping of decreased objective function values to coordinates by modified Dual Generalized Regression Neural Networks constructed from probe points.

The parameters of the search are controlled by an evolutionary algorithm. The algorithm forms a population of evolving rules each containing a tuple of parameter values. There are two measures of fitness: short-term (charm) and long-term (merit). Charm is used to select rules for reproduction and application. Merit determines survival of an individual. This two-fold system preserves potentially useful individuals from extinction due to short-term situation changes.

Test problems of 100 variables were solved. The results indicate that evolutionary control is better than random variation of parameters for NNAICM-PSO. With some problems, when rule bases are reused, error progressively decreases in subsequent runs, which means that the method adapts to the problem.
Global optimization via neural network approximation of inverse coordinate mappings with evolutionary parameter control
Authors: Пушкарев Кирилл Владимирович
Published: July 2019

Представлен гибридный метод глобальной оптимизации НАИЗ-PSO на основе нейросетевой аппроксимации инверсных зависимостей (координат от значений целевой функции) и метода роя частиц, служащий для нахождения глобального минимума непрерывной целевой функции многих переменных в области, имеющей вид многомерного параллелепипеда. Целевая функция рассматривается как абстрактная вычислительная процедура («чёрный ящик»).

Метод использует группы пробных точек, движущихся как в методе роя частиц. Одна из возможных целей движения определяется через отображение пониженных значений целевой функции в координаты посредством модифицированных дуальных обобщённо-регрессионных нейронных сетей, конструируемых по пробным точкам.

Параметрами процесса управляет эволюционный алгоритм. В алгоритме управления популяция состоит из эволюционирующих правил, заключающих в себе наборы параметров. Для оценки приспособленности особи используются две числовые характеристики: краткосрочная (очарование) и долгосрочная (достоинство). По очарованию правила отбираются для размножения и применения. Достоинством определяется выживание особи при формировании новой популяции. Двойная оценка правил решает проблему вымирания потенциально полезных особей при краткосрочном изменении ситуации.

Преимущество эволюционного управления над случайным изменением параметров НАИЗ-PSO в процессе поиска, а также тенденция к уменьшению погрешности при повторном использовании базы правил показаны на тестовых задачах с целевыми функциями 100 переменных.
Are Learned Molecular Representations Ready for Prime Time?
Authors: Yang Kevin , Swanson Kyle , Jin Wengong , Coley Connor , eiden philipp , Gao Hua , Guzman-Perez Angel , Hopper Timothy , Kelley Brian P. , mathea miriam , Palmer Andrew , Settels Volker , S Jaakkola Tommi , Jensen Klavs F. , Barzilay Regina
Published: July 2019

Advancements in neural machinery have led to a wide range of algorithmic solutions for molecular property prediction. Two classes of models in particular have yielded promising results: neural networks applied to computed molecular fingerprints or expert-crafted descriptors, and graph convolutional neural networks that construct a learned molecular representation by operating on the graph structure of the molecule. However, recent literature has yet to clearly determine which of these two methods is superior when generalizing to new chemical space. Furthermore, prior research has rarely examined these new models in industry research settings in comparison to existing employed models. In this paper, we benchmark models extensively on 19 public and 16 proprietary industrial datasets spanning a wide variety of chemical endpoints. In addition, we introduce a graph convolutional model that consistently matches or outperforms models using fixed molecular descriptors as well as previous graph neural architectures on both public and proprietary datasets. Our empirical findings indicate that while approaches based on these representations have yet to reach the level of experimental reproducibility, our proposed model nevertheless offers significant improvements over models currently used in industrial workflows.
Tracking the Metal-Centered Triplet in Photoinduced Spin Crossover of Fe(phen)32+ with Tabletop Femtosecond M-edge XANES
Authors: Zhang Kaili , Ash Ryan , Girolami Gregory S , Vura-Weis Josh
Published: July 2019

Fe(II) coordination complexes are promising alternatives to Ru(II) and Ir(III) chromophores for photoredox chemistry and solar energy conversion, but rapid deactivation of the initial metal-to-ligand charge transfer (MLCT) state to low-lying (d,d) states limits their performance. Relaxation to a 5T2g state is postulated to occur via a metal-centered triplet state, but this mechanism remains controversial. We use femtosecond extreme ultraviolet (XUV) transient absorption spectroscopy to measure the excited-state relaxation of Fe(phen)32+ and conclusively identify a 3T intermediate that forms in 170 fs and decays to a vibrationally hot 5T2g state in 40 fs. A coherent vibrational wavepacket with a period of 250 fs and damping time of 0.66 ps is observed on the 5T2g surface, and the spectrum of this oscillation serves as a fingerprint for the Fe-N symmetric stretch. The results show that the shape of the M2,3-edge X-ray absorption near edge structure (XANES) spectrum is sensitive to the electronic structure of the metal center, and the high spin sensitivity, fast time resolution, and tabletop convenience of XUV transient absorption make it a powerful tool for studying the complex photophysics of transition metal complexes.
Accelerated Computation of Free Energy Profile at ab Initio Quantum Mechanical/Molecular Mechanics Accuracy via a Semi-Empirical Reference Potential. II. Recalibrating Semi-Empirical Parameters with Force Matching
Authors: Pan Xiaoliang , Li Pengfei , Ho Junming , Pu Jingzhi , Mei Ye , Shao Yihan
Published: July 2019

An efficient and accurate reference potential simulation protocol is proposed for producing ab initio quantum mechanical molecular mechanical (AI-QM/MM) quality free energy profiles for chemical

reactions in a solvent or macromolecular environment. This protocol involves three stages: (a) using force matching to recalibrate a semi-empirical quantum mechanical (SE-QM) Hamiltonian for the specific reaction under study; (b) employing the recalibrated SE-QM Hamiltonian (in combination with molecular mechanical force fields) as the reference potential to drive umbrella samplings along the reaction pathway; and (c) computing AI-QM/MM energy values for collected configurations from the sampling and performing weighted thermodynamic perturbation to acquire AI-QM/MM corrected reaction free energy profile. For three model reactions (identity SN2 reaction, Menshutkin reaction, and glycine proton transfer reaction) in aqueous solution and one enzyme reaction (Claisen arrangement in chorismate mutase), our simulations using recalibrated PM3 SE-QM Hamiltonians well reproduced AI-QM/MM free energy profiles (at the B3LYP/6-31G* level of theory) all within 1 kcal/mol with a 20 to 45 fold reduction in the computer time.
Methane Activation by CoOₘⁿ⁺ (n = 0, 1, 2; m= 1, 2): Reactivity Parameters, Electronic Properties and Binding Energy Analysis
Authors: Ramalho Teodorico
Published: July 2019

The need for renewal, more efficient and conscious usage of energy resources has led to a great interest in carrying out studies aiming to find novel sources of energy, which are able to supply the growing global demand, and at the same time, providing an ecofriendly usage of natural resources. In this context, the usage of methane stands out as a promising energetic alternative for this goal, mostly due to the existence of vast reserves, its low cost and less polluting fuel. For theoretical calculations B3LYP, CCSD(t) and ZORA-B3LYP methods were used to look into the catalytic properties of (CoOₘⁿ⁺ n= 0, 1, 2 and m=1, 2) in the methane C-H bond activation. According to the EDA outcomes, the studied species presented two stabilizing factors for the global interaction energy, being the electrostatic ΔEelstat and orbital ΔEorb interactions. The HOMO and LUMO orbitals were also evaluated based on the molecular orbital diagrams for the monoxides and dioxides series. Regarding the oxidative insertion mechanism, the outcomes demonstrate that the initial interaction between oxide and methane is of great relevance in its activation process, in which EBonding is benefited by the increasingly charge on the central metal. The high electron density regarding the oxides is meaningful for the reaction kinetics and the oxo ligands influence the thermodynamics of the reaction, becoming the DHA mechanism exergonic. Regarding the OHM mechanism, better kinetic conditions are found for CoO2++ and better thermodynamics for doubly charged cobalt monoxides and dioxides.
On the Use of Quantum Thermal Bath in Unimolecular Fragmentation Simulations
Authors: Spezia Riccardo , Dammak Hichem
Published: July 2019

In the present work we have investigated the possibility of using the Quantum Thermal Bath (QTB) method in molecular simulations of unimolecular dissociation processes. Notably, QTB is aimed in introducing quantum nuclear effects with a com- putational time which is basically the same as in newtonian simulations. At this end we have considered the model fragmentation of CH4 for which an analytical function is present in the literature. Moreover, based on the same model a microcanonical algorithm which monitor zero-point energy of products, and eventually modifies tra- jectories, was recently proposed. We have thus compared classical and quantum rate constant with these different models. QTB seems to correctly reproduce some quantum features, in particular the difference between classical and quantum activation energies, making it a promising method to study unimolecular fragmentation of much complex systems with molecular simulations. The role of QTB thermostat on rotational degrees of freedom is also analyzed and discussed.
Highly Anisotropic Thermal Transport in LiCoO2
Authors: Yang Hui , Yang Jia-Yue , Savory Christopher , Skelton Jonathan , Morgan Benjamin , Scanlon David , Walsh Aron
Published: July 2019

LiCoO2 is the prototype cathode in lithium ion batteries. It adopts a crystal structure with alternating Li+ and CoO2- layers along the hexagonal <0001> axis. It is well established that ionic and electronic conduction is highly anisotropic; however, little is known regarding heat transport. We analyse the phonon dispersion and lifetimes of LiCoO2 using anharmonic lattice dynamics based on quantum chemical force constants. Around room temperature, the thermal conductivity in the hexagonal ab plane of the layered cathode is ≈ 6 times higher than that along the c axis based on the phonon Boltzmann transport. The low thermal conductivity (< 10Wm-1K-1) originates from a combination of short phonon lifetimes associated with anharmonic interactions between the octahedral face-sharing CoO2- networks, as well as grain boundary scattering. The impact on heat management and thermal processes in lithium ion batteries based on layered positive electrodes is discussed.
Pengaruh Lama Perkecambahan Terhadap Rendemen, Kadar Antosianin, Vitamin E dan Aktivitas Antioksidan Kecambah Kedelai Hitam
Authors: Asropah Siti , Nurrahman Nurrahman , Hersoelistyorini Wikanastri
Published: July 2019

Germination process can increase the nutritional value and functional properties that exist in the grain. Black soybeans contains anthocyanin, vitamin E and antioxidant activity that is beneficial to health. This study aims to determine the effect of long germination on rendement, anthocyanin, vitamin E levels and antioxidant activity on black soybean sprouts. Preliminary studies includes optimalization the length of germination and characterization of black soybean seeds. The main research includes physical and chemical analysis of rendement measurement, anthocyanin content, vitamin E content and antioxidant activity.  Then, analysis of proximate content on black soybean sprouts best result from long treatment of germination. The data measurement of black soybeans sprouts was obtained a digital scales and spectrophotometer UV-Vis. The results showed that (1) The germination has an effect on rendement, anthocyanin, vitamin E levels and antioxidant activity on black soybean sprouts. (2) In 40 hours long germination treatment showed anthocyanin level (91.84 mg / 10 g) and antioxidant activity (24.51% RSA) has the highest value. (3) The longer of germination has higher value on rendement percentage and vitamin E content.
Karakteristik Minuman Ready to Drink dengan Variasi Konsentrasi CMC dan Rasio Kacang Tunggak dan Kacang Hijau
Authors: Mukmina Tala Desicha Amalia , Prameswari Ratih Lido , Hapsari Relita Indar , Muflihati Iffah , Affandi Arief Rakhman
Published: July 2019

Indonesia is a country that is rich in natural resources and has the potential of local food from various types of beans that have the potential to add nutrients to the diet or daily menu. One of them is cowpea, which is still a lot of people have not processed the beans optimally. So as to increase the economic value and increase the variation of processed cowpea made by cowpea juice mixed with green beans (1: 3; 2: 2; 3: 1) with the addition of CMC (0.1%, 0.2%, 0.3 %) as stabilizer. The effect of CMC on green bean juice drinks and cowpea juice resulted in a descriptive test not significantly different while the preference test was found in the 1: 3 treatment with 0.1% CMC concentration. The highest total sugar is 1: 3 treatment with the addition of 0.2% CMC concentration of 10.6% while the lowest total sugar is in treatment 3: 1 addition of 0.3% CMC concentration of 4.89%. Protein levels in the treatment of 1: 3 added 0.1% CMC concentration which was equal to 5.74%.
Desain Pembelajaran Luas Lingkaran dengan Konteks Explore Dapur Berbasis Realistic Mathematics Education (RME) di Kelas VIII Sekolah Menengah Pertama (SMP)
Authors: Budiyono Asep , Kusumaningsih Widya , Albab Irkham Ulil
Published: July 2019

Penelitian ini bertujuan untuk mengetahui peran Hypothetical Learning Trajectory(HLT)dalam membantu siswa dalam memahami konsep luas lingkaran serta mengetahui strategi yang digunakan oleh siswa terhadap Hypothetical Learning Trajectory(HLT) yang diberikan. Penelitian ini dilaksanakan di SMP Negeri 3 Petarukan, Kabupaten Pemalang. Subjek penelitian adalah siswa kelas VIII, dengan melalui 2 tahap yaitu pilot experiment melibatkan 6 siswa dari kelas VIII C dan dilanjutkan teaching experiment yang melibatkan 30 siswa dari kelas VIII B. Penelitian ini menggunakan metode design research yang didalamnya terdapat HLT yang memegang peranan sangat penting sebagai desain dan instrumen penelitian. Pembelajaran dalam penelitian ini menggunakan konteks peralatan dapur yaitu gelas, piring dan mangkuk sesuai dengan karakteristik dari RME. Hasil Penelitian menunjukkan bahwa Hypothetical Learning Trajectory (HLT) dapatmembantu siswa 1) membuat potongan juring lingkaran dan mengubahnya menjadi sebuah bangun datar baru yaitu trapesium, 2) menemukan sendiri konsep luas lingkaran dengan pendekatan trapesium, 3) menyelesaikan permasalahan dalam kehidupan sehari-hari yang berkaitan dengan konsep luas lingkaran. Adapun strategi yang digunakan siswa yaitu 1)mensketsakan permukaan perlatan dapur berupa lingkaran, 2) membandingan keliling dan diameter lingkaran untuk memperoleh nilai phi, 3)menyusun juring menjadi trapesium dan memformulasikan konsep luas lingkaran, 4) menerapkan konsep luas lingkaran.
Analisis Berpikir Kritis Siswa SMP dalam Menyelesaikan Soal Matematika Bentuk Cerita
Authors: Maharani Resa , Rasiman Rasiman , Rahmawati Noviana Dini
Published: July 2019

Tujuan penelitian ini adalah mendeskripsikan kemampuan berpikir kritis siswa SMP dalam menyelesaikan soal matematika bentuk cerita pada materi aljabar. Berpikir kritis merupakan salah satu masalah penting dalam pembelajaran matematika. Penelitian ini merupakan penelitian deskriptif kualitatif dengan subjek penelitiannya adalah siswa kelas VII A SMP Negeri 19 Semarang yang terdiri dari tiga siswa, siswa berkemampuan matematika tinggi, siswa berkemampuan matematika sedang dan siswa berkemampuan matematika rendah. Teknik pengumpulan data yang digunakan adalah observasi, tes dan wawancara. Teknik analisis data dilakukan dengan reduksi data, penyajian data dan penarikan kesimpulan. Teknik pemeriksaan keabsahan data dengan menggunakan triangulasi metode. Hasil penelitian menunjukan bahwa siswa kemampuan matematika sedang memiliki kemampuan berpikir kritis lebih baik, dibandingkan dengan siswa yang memiliki kemampun matematika tinggi. Sedangkan pada siswa dengan kemampuan matematika tinggi memiliki kemampuan berpikir kritis lebih baik dibandingkan dengan siswa yang berkemampuan matematika rendah.
Pengaruh Mengonsumsi Minuman Berkarbonasi Terhadap Erosi Gigi Insisivus Permanen Rahang Atas
Authors: Lestari Novia Ayu , Suryatmojo Ibnu , Sembiring Linda Sari
Published: July 2019

Minuman berkarbonasi merupakan salah satu minuman paling digemari oleh masyarakat. Minuman berkarbonasi bersifat asam dengan pH 2-2,3-7 yang dapat menyebabkan erosi gigi terutama pada gigi insisivus rahang atas. Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh mengonsumsi minuman berkarbonasi terhadap erosi gigi insisivus permanen rahang atas dan apakah mengonsumsi minuman berkarbonasi dengan durasi waktu yang berbeda memberikan pengaruh tingkat erosi yang berbeda terhadap gigi insisivus rahang atas.

Pada penelitian ini, gigi insisivus rahang atas sebanyak 8 buah dilakukan simulasi pengaliran minuman berkarbonasi dengan waktu 5 menit dan 10 menit. Sebelum dan sesudah simulasi pengaliran akan dilakukan uji  Scanning Electron Microscope untuk mengukur lebar erosi.

Berdasarkan hasil Scanning Electron Microscope, didapatkan kenaikan lebar erosi sebesar 0,60 ?m pada kelompok pengaliran 5 menit dan 2,17 ?m pada kelompok pengaliran 10 menit. Hasil penelitian diuji dengan t-test berpasangan dan didapat p value < 0.05. Simpulan dari penelitian ini adalah terdapat pengaruh mengonsumsi minuman berkarbonasi terhadap tingkat erosi gigi insisivus permanen rahang atas berdasarkan lamanya durasi waktu konsumsi.
Pengaruh Mengonsumsi Tomat Ceri (Solanum lycopersicum L. var. cerasiforme) Terhadap Indeks Plak Gigi
Authors: Rabbani Adzra Nashira , Soegiharto Georgius Soetjipto , Evacuasiany Endang
Published: July 2019

Tomat (Solanum lycopersicum L.) sudah banyak digunakan dalam bidang kesehatan karena memiliki daya antioksidan, anti-inflamasi, dan anti bakteri. Tomat memiliki beragam jenis salah satunya tomat ceri (Solanum lycopersicum L. var. cerasiforme). Pada bidang kedokteran gigi kandungan tomat biasa digunakan untuk beberapa penyakit rongga mulut. Penelitian ini bertujuan untuk mengetahui pengaruh mengonsumsi tomat ceri (Solanum lycopersicum L. var. cerasiforme) terhadap indeks plak gigi.

Penelitian ini menggunakan metode eksperimental semu dengan desain pre-test dan post-test. Subjek penelitian terdiri dari 23  subjek  dengan kelompok  yang  sama.  penelitian dilakukan dalam jangka  waktu 7  hari dan pemeriksaan dilakukan ketika sebelum dan setelah mengonsumsi tomat ceri (Solanum lycopersicum L. var. cerasiforme) serta dilakukan perhitungan indeks plak menggunakan metode O’leary pada hari ke-1,3, dan 7. Analisis data dilakukan dengan uji t berpasangan (? = 0,05) dan uji normalitas dilakukan dengan uji Shapiro-Wilk. Hasil uji statistik penelitian menunjukan bahwa terdapat perbedaan penurunan rata-rata indeks plak setelah mengonsumsi tomat ceri Solanum lycopersicum L. var. cerasiforme) yang signifikan yaitu pada hari ke-1 sebesar 13,548, hari ke-3 sebesar 14,128 dan hari ke-7 sebesar 12,652 dan data tersebut memenuhi p<0,05. Dapat disimpulkan bahwa tomat ceri (Solanum lycopersicum L. var. cerasiforme) dapat menurunkan indeks plak gigi.
Perbedaan Kebersihan Sepertiga Apikal Saluran Akar dari Smear Layer Menggunakan Sistem Aktivasi Ultrasonik dan Sonik
Authors: Puspita Della , Djuanda Rudy , Evelyna Angela
Published: July 2019

Irrigant activation is important for successful endodontic treatment. There are some of activation technique those are manual irrigation with needle irrigation and mechanics irrigation with sonic, and ultrasonic activation. The aim of this study was to compare the effectiveness between sonic and ultrasonic activation technique as irrigation activation for smear layer removal in apical third of the root canal. Fifteen mandibular premolars were used. NaOCl 2,5% and EDTA 17% was used as an irrigant. Sample were divided into 3 equal group (n=5) according to the final activation technique: group I as a needle irrigation  II as a ultrasonic activation, group III sonic activation. Root canals were split longitudinnaly and subjected to scanning electron microscope with 2000x magnification. Data were evaluated using statistics kruskall wallis and mann whitney. The result of this study shows there were statistically significant differences in staistics Mann Whitney on group III  were more clean than group II p < 0,05. Sonic technique more effective in removal of smear layer in apical third of the root canal than ultrasonic activation technicque. Important to noted the variant of irrigant and activation.
Peranan Sel Punca dalam Meregenerasi Jaringan Pulpa Gigi
Authors: Sugiaman Vinna Kurniawati
Published: July 2019

Injury pada pulpa gigi dapat menyebabkan terjadinya perubahan pada pulpa secara histopatologi, yang apabila terus berlanjut akan menyebabkan kerusakan pulpa menjadi irreversible sampai dengan kematian yang pada akhirnya perlu untuk dilakukan perawatan endodontik. Perawatan ini dapat mempertahankan gigi di rongga mulut dalam kondisi non vital, sehingga belakangan ini dikembangkan suatu teknologi baru yaitu teknologi tissue engineering dengan memanfaatkan sel punca, matriks, dan growth factor untuk meregenerasi jaringan yang mengalami kerusakan. Pada proses regenerasi, sel punca akan mengalami proliferasi dan diferensiasi menjadi berbagai macam sel yang terdapat pada jaringan pulpa, sehingga proses regenerasi jaringan pulpa yang mengalami kerusakan dapat terjadi dan pulpa dapat tetap dalam kondisi vital bertahan di rongga mulut.
Intercultural Communication Between International Military Organizations: How Do You Turn a ‘No’ Into a ‘Yes’?
Authors: A Straka Douglas
Published: July 2019

Government, private business, and academia have been placing increasing emphasis on collaboration in multi-stakeholder, multicultural environments. Persons working within the Department of Defense Theater Security Cooperation environment must regularly interact with others coming from cultures that are dissimilar to their own. They must adapt to these different cultural environments.
Is a Culture of Innovation Meaningless to Management?
Authors: R. Gregory James
Published: July 2019

A culture of innovation is an attribute in business, which can be measured both qualitatively and quantitatively. The measurement of innovation empirically correlates with other measures of the corporate brand, such as overall reputation, perception of management, and investment potential. It seems logical then that the process of innovation may be a more strategic tool that is akin to corporate branding, rather than being a tactical component of product development.
Whether developing innovative products or strategically building a culture of innovation in a company both require a commitment of a corporation’s management to provide resources, which means innovation should be financially accountable. Accountability requires measuring the return on innovation investment despite it being an internally grown intangible asset, which according to accounting standards cannot appear on the balance sheet.
This paper is one of a series that will examine the culture of innovation as it relates to marketing and branding measures in a quantitative research survey known as the CoreBrand Index® (CBI). This purpose of this paper is to examine what came before the CBI. It will be a prequel to the primary work, which will evaluate the feasibility of measuring innovation as an indicator of business health and financial vitality, which may ultimately become a predictor of future revenue and cash flow. Ultimately, we would like to see internally grown intangible assets on the balance sheet, but at the very least we would like to see that they have some financial accountability.
We hope to better understand what drives intangible assets like innovation, and how can it be measured, valued, and managed. To that end, we begin by examining areas we have not explored previously even after 25 years of measuring corporate brands.
Jung, History and His Approach to the Psyche
Authors: Lu Kevin
Published: July 2019

The continued existence of analytical psychology in the academy has largely depended on applications of analytical psychology to other disciplines. These attempts at “applied psychoanalysis” are in danger, however, of becoming examples of “wild psychoanalysis.” To remedy this, applications need to work at the interface of the two disciplines in question, building a firm foundation as the basis of dialogue. In this paper, I address the application of analytical psychology to the discipline of history by first exploring the ways in which ‘history’ and the historical method influenced, and found expression in, Jung’s psychology. Given the extent to which Jung evoked ‘history’ and depended on it as a hermeneutical framework, Petteri Pietikainen’s argument – that a revision of archetypal theory needs to occur if analytical psychology is to conduct meaningful analyses of culture – requires deeper consideration.
Re-reading Sophocles’s Oedipus Plays
Authors: Martinez Inez
Published: July 2019

Sophocles’s Oedipus plays depict failed integration of self-knowledge as worthy of divinization. Acting out vengeance is the evidence of Oedipus’s failed integration. Oedipus’s task of integration pivots on grasping in what sense he can be understood as guilty. His plight demonstrates that ignorance is part of unconsciousness and, contrary to Jung’s attitude toward ignorance, requires some kind of coping with responsibility. Vengeance was a conscious value among the ancient Greeks. In Sophocles’s last play, Oedipus at Colonus, Oedipus acts out vengeance against his sons, and Sophocles divinizes this acting out through having Oedipus join the goddesses, the Furies. This divinization suggests that vengeance is archetypal, depending on culture only for images of manifestation. I argue that Oedipus’s acting out of vengeance can be read as symptomatic of a cultural complex. I identify the situation leading to his acting out as his failure to imagine how creatively to take responsibility for his parricide and incest. Reading Oedipus’s acting out as failure to integrate his self-knowledge opens up the question of what successful integration could have entailed. I turn to work by Edward C. Whitmont to suggest what acceptance of responsibility for deeds not intended might look like. Finally, I turn to work by Gottfried M. Heuer to address the issues of power and love raised by Oedipus’s dilemma. In order to read these plays in terms of Jung’s concepts of visionary literature and of integration, I critique and discard two literary critical concepts used in previous criticism of Sophocles’s plays: 1) that the intention of the author determines meaning in a text; and 2) that no framework beyond those given in a play may be used to interpret meaning.
Writing Nature with Darwin, Darwinism and Jung
Authors: Rowland Susan
Published: July 2019

Charles Darwin and C. G. Jung were revolutionary thinkers about the role of human beings in the natural world. While Darwin’s Origins of Species (1859) sought to remove both God and “man” from the centre of the understanding of nature, C. G. Jung, one generation later, aimed to remove the ego from the central definition of human nature. Although both theorists have been explored for their conceptual ideas, neither has been seriously considered as writers, and in particular as writers of nature and human nature. This paper shows how similar these authors are in treating the unknowable in the psyche and history as of major significance. In particular, both writers require the resources of ancient myth, especially of nature as an Earth Mother goddess in order to represent the inconceivable. The paper also looks at the new critical practice of “literary Darwinism,” which, while viable in its own terms, suffers from being neither “literary,” nor “Darwinian.”
Literature and the Shaman:
Authors: Rowland Susan
Published: July 2019

The paper first considers the role of Jungian ideas in relation to academic disciplines and to literary studies in particular. Jung is a significant resource in negotiating developments in literary theory because of his characteristic treatment of the ‘other’. The paper then looks at The Lion, the Witch and the Wardrobe (1950) by C.S. Lewis whose own construction of archetypes is very close to Jung’s. By drawing upon new post-Jungian work from Jerome Bernstein’s Living in the Borderland (2005), the novel is revealed to be intimately concerned with narratives of trauma and of origin. Indeed, a Jungian and post-Jungian approach is able to situate the text both within nature and in the historical traumas of war as well as the personal traumas of subjectivity. Where Bernstein connects his work to the postcolonial ethos of the modern Navajo shaman, this new weaving of literary and cultural theory points to the residue of shamanism within the arts of the West.
“Gypsy” Fate:
Authors: Fidyk Alexandra
Published: July 2019

Narratives, both individual and collective, are a primary embodiment of our understanding of the world, others, and ultimately ourselves. As a receptive and a creative activity, they tell us how we are always already caught up in the enacting and re-constructing of stories. Here a Romani narrative, a collective identity constructed through negative inflation, exile, and splitting, is read through the lense of a “scapegoat” complex. Such a reading points to the way we are split between any form of “us” and “them” – conscious and unconscious, light and dark. Non-Roma or Gadje, then, are not separate from this “other” but are co-creating and co-living this identity and narrative. Addressing the unconscious, personally and collectively, becomes our ethical responsibility so that we become aware of both our shadow and the other with whom we manifest (and blame). In attending the “problem” of the scapegoat, I  hope to extend not only the discussion of difference in teaching and research but also in our social or political response toward people, in particular the Roma, and other ethnic and visible minorities who have been denied rights, persecuted and discriminated.
“Sonny’s Blues” and Cultural Shadow
Authors: Martinez Inez
Published: July 2019

James Baldwin’s short story, “Sonny’s Blues,” portrays a jazz artist’s transformation of an historic and ongoing aspect of America’s cultural shadow, treating black people cruelly as if they were not real. He is enabled to bring about this transformation through his becoming conscious of and owning his personal shadow, treating people regardless of race cruelly as if they were not real. His self-knowledge indicates an equality in the human potential of behaving oppressively and thus frees him from the self-pity and helpless rage of victimization possible to those having suffered the injustice of racism. It thus frees him to create music free of lament, music which in turn frees his brother, who has responded to American racism with repression of his emotions, to feel his grief. Baldwin’s story implies that art, such as the story “Sonny’s Blues,” can express a society’s unjustly caused suffering without lament if the artist has taken responsibility for having him or herself unjustly caused suffering. This art is portrayed as freeing its audience through new consciousness and feeling to develop a new relationship with cultural shadow, one suggesting a beginning of its integration.
Synchronicity in the 21st Century
Authors: Lorenz Helene Shulman
Published: July 2019

Synchronicity in the 21st Century