bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating Inflammatory Cytokine Associated with Poor Prognosis in Moyamoya Disease: A Prospective Cohort Study
Authors: Liu Wei , Sun Jian , Shi Zhiyong , Huang Zheng , Yu Lebao , Du Haibin , Ge Peicong , Zhang Dong
Published: January 2023

Inflammation is a key factor in the development of moyamoya disease. However, the cytokine distribution in moyamoya disease and its impact on prognosis remain unclear. A total of 204 patients with moyamoya disease were enrolled in this study. The peripheral blood was analyzed for baseline data and cytokines, which included IL-6, IL-1β, IL-2R, IL-8, and TNF-α. Patients with the RNF213 mutation and those without the mutation were compared in terms of their differences in cytokines. A mRS score ≥2 was defined as a poor prognosis, and a mRS score <2 was described as a good prognosis, and differences in cytokines were compared between the two groups. Regression analysis was performed to identify markers affecting prognosis. TNF-α and IL-6 levels were higher in the group without the RNF213 mutation compared to the mutation group. Multivariate stepwise regression analysis indicated that the G3 subgroup of IL-6 and the G4 subgroup of TNF-α were the independent risk factors for adverse prognosis in adults with moyamoya disease (OR 3.678, 95% CI [1.491, 9.074], p = 0.005; OR 2.996, 95% CI [1.180, 7.610], p = 0.021). IL-6 and TNF-α were associated with poor prognosis in adult patients with moyamoya disease.
The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children
Authors: Füssiová Mária , Švec Peter , Horáková Júlia , Sedláček Petr , Rohoň Peter , Celec Peter , Boďová Ivana , Adamčáková Jaroslava , Sýkora Tomáš , Dobšinská Veronika , Pozdechová Miroslava , Dóczyová Dominika , Vargová Santia , Kolenová Alexandra
Published: January 2023

Background: Early recognition and specific therapy facilitate a favorable disease course in hepatic venous-occlusive disease (HVOD) following hematopoietic stem cell transplantation (HCT). Diagnostic and classification criteria, published by the European Society for Blood and Marrow Transplantation (EBMT), better account for clinical differences in disease presentation in pediatric populations. Objectives: To compare the course of HVOD in children before and after the implementation of new EBMT criteria. Material and methods: The study retrospectively evaluates 26 HVODs in 179 children treated in a single HCT unit (Slovakia) comparing the period of 2014–2017 using the Baltimore and modified Seattle criteria with the period of 2018–2021, when new EBMT criteria were adopted. Results: No difference in HVOD incidence (11.2% vs. 14.8%, p = 0.46) and in time of diagnosis post-HCT (15.6 days vs. 15.7 days, p = 0.75) was found. With EBMT criteria we observed more frequent anicteric disease at diagnosis (50% vs. 87.5%, p = 0.04), lower serum bilirubin at diagnosis (3.4 mg/dL vs. 1.23 mg/dL, p = 0.045), and non-significant trends of shorter defibrotide treatment (21.7 days vs. 15.6 days, p = 0.73), decreased mortality (30% vs. 6.2%, p = 0.10) and shorter hospitalization (73.1 days vs. 59.6 days, p = 0.54). Conclusions: Different time periods around the implementation of new criteria are evaluated, underling that pediatric EBMT criteria for post-transplant HVOD diagnosis appear more sensitive.
Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
Authors: Ishikawa Ayaka , Matsushita Hiroshi , Shimizu Saki , Morita Noriko , Hanai Rina , Sugiyama Saeko , Watanabe Kazushi , Wakatsuki Akihiko
Published: January 2023

Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of this study was to elucidate the effects of endogenous estrogen on oxidative stress in women. Thus, we performed a non-interventional observational study of healthy postmenopausal (n = 71) and premenopausal (n = 72) female volunteers. Serum levels of derivatives of reactive oxygen metabolites (d-ROMs, which are collectively a marker of oxidative stress), as well as the biological antioxidant potential (BAP, an indicator of antioxidant capacity), were compared between (1) pre- versus post-menopausal women, and (2) premenopausal women in early follicular versus mid-luteal phases of their menstrual cycles. We found that serum d-ROMs and BAP values in postmenopausal women were significantly higher than those in premenopausal women. Moreover, the d-ROM levels were significantly correlated with serum copper concentrations. However, neither d-ROMs nor BAP values were significantly affected by the menstrual cycle phase, although changes in d-ROMs between the follicular and luteal phases were significantly correlated with copper concentration shifts. These data indicate that postmenopausal hypoestrogenism is associated with elevated oxidative stress, although regular fluctuations of estrogen levels during the menstrual cycle do not influence oxidative stress.
Acute Localized Exanthematous Pustulosis (ALEP) Caused by Topical Application of Minoxidil
Authors: Makris Michael , Kanelleas Antonios , Papapostolou Niki , Pisimisi Maria , Katoulis Alexander C.
Published: January 2023

Acute Localized Exanthematous Pustulosis (ALEP) is a rare skin reaction characterized by the sudden onset of multiple, small, sterile, non-follicular pustules in an erythematous and edematous base succeeding systemic drug administration. ALEP is considered a subtype of Acute Generalized Exanthematous Pustulosis (AGEP), although the exact pathogenic mechanism of the disease remains poorly defined. Numerous drugs have been implicated in the pathogenesis of ALEP, while contact mechanisms have also been reported. Herein, we describe the first case of ALEP attributed to minoxidil in a female patient with androgenetic alopecia. The positivity of patch tests and the topical application of minoxidil proposes a contact-induced hypersensitivity reaction. Identifying new agents—including minoxidil—which serve as inducers of drug-specific T-cell-mediated responses in the clinical spectrum of ALEP, adds further value in understanding the complex, yet unknown, pathophysiological mechanisms of this rare drug hypersensitivity reaction.
Optimization of LED Array Spatial Coverage Characteristics in Underwater Wireless Optical Communication
Authors: Liu Anliang , Yuan Yingming , Yin Hongxi , Zhao Haobo , Fu Xianping
Published: January 2023

To achieve uniform spatial coverage characteristics in optical signals in an underwater wireless optical communication (UWOC) system, and therefore reduce the requirement of the alignment between the receiver and the transmitter, we propose an optimized scheme of optical signal coverage based on a light-emitting diode (LED) array in this paper. For high-efficiency coverage of the optical signals, the pitch angle of the LED light source is first optimized on the basis of the light beam geometry. Then, the layout of the LED array and the horizontal deflection angle of the light source are jointly optimized by an improved particle swarm optimization (PSO) algorithm. Taking a 16-LED array as an example, the performances of the spatial coverage characteristics with three different LED array layouts are analyzed in detail under four typical seawater environments. The results show that the LED array with the PSO-optimized layout can achieve better uniformity in the power distribution for the received optical signals, and enhance the robustness of the UWOC system in complex seawater environments.
Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer
Authors: Ortega Miguel A. , Pekarek Leonel , Navarro Fátima , Fraile-Martínez Oscar , García-Montero Cielo , Álvarez-Mon Miguel Ángel , Diez-Pedrero Raúl , Boyano-Adánez María del Carmen , Guijarro Luis G. , Barrena-Blázquez Silvestra , Gómez-Lahoz Ana M. , Haro Sergio , Arroyo Mónica , Monserrat Jorge , Saez Miguel A. , Alvarez-Mon Melchor
Published: January 2023

Non-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main causes of oncological death and the oncological diseases with the highest incidence worldwide. With regard to clinical approaches for NSCLC, several advances have been achieved in diagnosis and treatment; the analysis of different molecular markers has led to the development of new targeted therapies that have improved the prognosis for selected patients. Despite this, most patients are diagnosed in an advanced stage, presenting a limited life expectancy with an ominous short-term prognosis. Numerous molecular alterations have been described in recent years, allowing for the development of therapies directed against specific therapeutic targets. The correct identification of the expression of different molecular markers has allowed for the individualization of treatment throughout the disease course, expanding the available therapeutic arsenal. The purpose of this article is to summarize the main characteristics of NSCLC and the advances that have occurred in the use of targeted therapies, thus explaining the limitations that have been observed in the management of this disease.
Rural Development under Poverty Governance: The Relationship between Rural Income and Land Use Transformation in Yunnan Province
Authors: Shi Xinyu , Zhao Xiaoqing , Huang Pei , Gu Zexian , Pu Junwei , Zhou Shijie , Qu Guoxun , Zhao Qiaoqiao , Feng Yan , Chen Yanjun , Xiang Aimeng
Published: January 2023

The process of eliminating absolute poverty is inevitable for China’s social and economic transformation. However, there are currently few studies on the relationship between land use transformation (LUT) and rural income under different stages of poverty governance. This study, therefore, uses spatial autocorrelation analysis and a multiscale geographic weighted regression (MGWR) model to explore the mechanisms of LUT on rural income and its spatiotemporal heterogeneity in Yunnan Province during the comprehensive poverty alleviation (CPA) period and the targeted poverty alleviation (TPA) period at the county scale. The results demonstrate that: (1) the numbers of both low-income and high-income counties continued to decrease, while the number of middle-high-income counties increased, and rural income demonstrated a positive spatial correlation. (2) Most of the variables in the dominant recessive increased in the CPA and decreased in the TPA period. As for recessive morphology, the ecological function variables decreased first and then increased. (3) The driving force of dominant morphology is strong and sustained, and the driving force of recessive morphology is gradually enhanced. The results are vital for consolidating the results of poverty eradication and bridging rural revitalization. They may also provide useful references for sustainable land use and effective poverty alleviation in other developing countries.
Identification and Optimization of Ecological Network in Arid Inland River Basin Using MSPA and Spatial Syntax: A Case Study of Shule River Basin, NW China
Authors: Pan Jinghu , Wang Yimin , Zhang Zhao
Published: January 2023

Habitat fragmentation has become an important factor in the reduction of biodiversity. Identifying and optimizing ecological networks (ENs) can help alleviate the negative impact of habitat fragmentation and improve regional biodiversity. Taolai River Basin is an inland river basin in Northwest China. Due to the impact of climate change and human activities, there are many ecological problems such as grassland degradation and shortage of water resources. It is urgent that we identify and optimize the EN. This study comprehensively uses morphological spatial pattern analysis (MSPA), the minimum cumulative resistance model (MCR), and circuit theory to identify ENs, evaluates ENs based on Spatial Syntax, and determines the protection priority of ENs, then diagnoses ecological “pinch points” and ecological obstacles by combining remote sensing and GIS spatial analysis methods. The results show that: (1) the ecological source area of the basin is 3061.63 km2, with uneven spatial distribution, mainly distributed in the Qilian Mountains in the south of the basin; (2) there are 106 ecological corridors in the basin, with a total length of 2267.30 km and an average length of 21.38 km, which is not conducive to species migration; (3) the optimum widths of ecological corridors in the south, middle, and north of the basin are 100 m, 60 m, and 300 m, respectively; (4) the key areas of watershed ecological restoration include the “pinch area” between the southern core area and the central core area and 108 ecological barrier points; and (5) combined with the spatial characteristics of various key areas of ecological protection and restoration, the spatial pattern of “one core–four rings–five belts” of watershed EN construction is obtained.
Dynamic MRI of the Mesenchymal Stem Cells Distribution during Intravenous Transplantation in a Rat Model of Ischemic Stroke
Authors: Cherkashova Elvira A. , Namestnikova Daria D. , Gubskiy Ilya L. , Revkova Veronica A. , Sukhinich Kirill K. , Melnikov Pavel A. , Abakumov Maxim A. , Savina Galina D. , Chekhonin Vladimir P. , Gubsky Leonid V. , Yarygin Konstantin N.
Published: January 2023

Systemic transplantation of mesenchymal stem cells (MSCs) is a promising approach for the treatment of ischemia-associated disorders, including stroke. However, exact mechanisms underlying its beneficial effects are still debated. In this respect, studies of the transplanted cells distribution and homing are indispensable. We proposed an MRI protocol which allowed us to estimate the dynamic distribution of single superparamagnetic iron oxide labeled MSCs in live ischemic rat brain during intravenous transplantation after the transient middle cerebral artery occlusion. Additionally, we evaluated therapeutic efficacy of cell therapy in this rat stroke model. According to the dynamic MRI data, limited numbers of MSCs accumulated diffusely in the brain vessels starting at the 7th minute from the onset of infusion, reached its maximum by 29 min, and gradually eliminated from cerebral circulation during 24 h. Despite low numbers of cells entering brain blood flow and their short-term engraftment, MSCs transplantation induced long lasting improvement of the neurological deficit, but without acceleration of the stroke volume reduction compared to the control animals during 14 post-transplantation days. Taken together, these findings indicate that MSCs convey their positive action by triggering certain paracrine mechanisms or cell–cell interactions or invoking direct long-lasting effects on brain vessels.
Differences in Mechanical and Physicochemical Properties of Several PTFE Membranes Used in Guided Bone Regeneration
Authors: Qasim Syed Saad Bin , Al-Asfour Adel A. , Abuzayeda Moosa , Mohamed Ahmed M. , Trajkovski Branko , Murray Colin Alexander , Zafiropoulos Gregor-Georg
Published: January 2023

Non-resorbable PTFE membranes are frequently used in dental-guided bone regeneration (GBR). However, there is a lack of detailed comparative studies that define variations among commonly used PTFE membranes in daily dental clinical practice. The aim of this study was to examine differences in physicochemical and mechanical properties of several recent commercial PTFE membranes for dental GBR (CytoplastTM TXT-200, permamem®, NeoGen®, Surgitime, OsseoGuard®-TXT, OsseoGuard®-NTXT). Such differences have been rarely recorded so far, which might be a reason for the varied clinical results. For that reason, we analyzed their surface architecture, chemical composition, tensile strength, Young’s modulus, wettability, roughness, density, thickness and porosity. SEM revealed different microarchitectures among the non-textured membranes; the textured ones had hexagonal indentations and XPS indicated an identical spectral portfolio in all membranes. NeoGen® was determined to be the strongest and OsseoGuard®-TXT was the most elastic. Wettability and roughness were highest for Surgitime but lowest for OsseoGuard®-NTXT. Furthermore, permamem® was the thinnest and NeoGen® was identified as the thickest investigated GBR membrane. The defect volumes and defect volume ratio (%) varied significantly, indicating that permamem® had the least imperfect structure, followed by NeoGen® and then Cytoplast TM TXT-200. These differences may potentially affect the clinical outcomes of dental GBR procedures.
Carbon Fibers Prepared via Solution Plasma-Generated Seeds
Authors: Romero Valenzuela Andres Eduardo , Chokradjaroen Chayanaphat , Choeichom Pongpol , Wang Xiaoyang , Kim Kyusung , Saito Nagahiro
Published: January 2023

Carbon fibers are materials with potential applications for CO2 capture due to their porous structure and high surface areas. Nevertheless, controlling their porosity at a microscale remains challenging. The solution plasma (SP) process provides a fast synthesis route for carbon materials when organic precursors are used. During the discharge and formation of carbon materials in solution, a soot product-denominated solution plasma-generated seeds (SPGS) is simultaneously produced at room temperature and atmospheric pressure. Here, we propose a preparation method for carbon fibers with different and distinctive morphologies. The control over the morphology is also demonstrated by the use of different formulations.
Simulation and Field Studies on an Innovative Downhole Machine Designed for Ultrashort-Radius Horizontal Well Drilling Engineering
Authors: Li Chenglong , Chen Zongtao , Wang Zenglin , Tian Qizhong , Dai Rongdong , Wang Kun
Published: January 2023

Ultrashort-Radius Horizontal Well (URHW) drilling engineering plays an important role in increasing the recovery factor of old oilfields. By sidetracking old wellbores at a very high build-up rate, the URHW can effectively exploit the residual oil near old wellbores. Currently, the main problem faced in URHW drilling engineering is the reduced torque received by drill bits owing to the increased friction between the flexible drilling assembly and wellbore as the horizontal section extends, which greatly limits oil production from a single trip. To tackle this problem, we proposed an innovative machine design, a Dynamic Flexible Drill Rod (DFDR), to provide extra torque near the drill bit to extend the horizontal section of the URHW. The interior structure and working principle of the DFDR were illustrated. The mechanical properties of the DFDRs critical load-bearing part were examined via simulation. The torque and pressure loss characteristics were analyzed using computational fluid dynamics. Corresponding modifications were made to optimize the design, with model machines produced accordingly. Field trials were carried out based on old wellbores in Chunliang District, Shengli Oilfield. The DFDR-based technique extended the URHWs horizontal section in this area by 13.38% on average.
Research on PID Controller of Excavator Electro-Hydraulic System Based on Improved Differential Evolution
Authors: Ma Wei , Ma Shoulei , Qiao Wenhua , Cao Donghui , Yin Chenbo
Published: January 2023

An electrical hydraulic control system (electro-hydraulic system) is thought to be a key component in excavator operation systems. Control methods with fixed parameters may not yield optimal system performances because a hydraulic system has various nonlinear uncertainties due to the leakage and compressibility of the fluid medium. Hence, a novel PID controller based on improved differential evolution (IDE) is introduced to excavator electro-hydraulic systems for interconnected hydraulic systems. The proposed algorithm not only adjusts the PID parameters of the different working conditions but also adjusts the scaling factor and crossover probability. Then, the proposed PID controller based on IDE and the excavator bucket control system are modeled and simulated on the MATLAB simulation platform. The simulation results demonstrate that the proposed controller has better performance in settling time, rise time, and convergence speed compared to the PID controller based on standard differential evolution and the Ziegler–Nichols (ZN) PID controller with a novel object function. Eventually, the IDE-PID controller is assessed on a 23-ton excavator, and good transient behavior and trajectory accuracy are obtained in comparison to the SDE-PID controller.
Cluster Observation of Ion Outflow in Middle Altitude LLBL/Cusp from Different Origins
Authors: Li Bin , Yang Huigen , Sun Jicheng , Hu Zejun , Liu Jianjun , Chen Xiangcai , Wang Yongfu , Ren Jie , Yue Chao , Escoubet C. Philippe , Wang Qian , Zong Qiugang
Published: January 2023

The ionosphere is the ionized part of the upper atmosphere that is caused mainly by photoionization by solar extreme ultraviolet (EUV) emission and the atmospheric photochemistry process. The ionospheric ions escape from the ionosphere and populate the Earth’s magnetosphere. In this case study, ion outflows from two different origins were obtained by spacecraft Cluster C1 in the magnetospheric cusp region. One of the outflows was from the reflection of the dispersed solar wind particles. The other was the ionospheric outflow passing through the low latitude boundary layer of the cusp (LLBL/cusp), which was energized by downward Poynting flux. Similar to the reflected solar wind particles, outflowing ionospheric cold ions could also extend to the high-latitude region with magnetic field line convection, which mixed it up with solar wind particles. Based on the Cluster observation in the cusp region, two different origins of the outflowing particles were determined, and their unique mechanisms of formation were discussed. Results suggest that the strong electric field associated with solar wind particle precipitation may additionally accelerate the cold ionospheric ion flow in the LLBL/cusp.
Smoothness of Graph Energy in Chemical Graphs
Authors: Zemljič Katja , Žigert Pleteršek Petra
Published: January 2023

The energy of a graph G as a chemical concept leading to HMO theory was introduced by Hückel in 1931 and developed into a mathematical interpretation many years later when Gutman in 1978 gave his famous definition of the graph energy as the sum of the absolute values of the eigenvalues of the adjacency matrix of G. One of the general requirements for any topological index is that similar molecules have close TI values, which is called smoothness. To explore this property, we consider two variants of structure sensitivity and abruptness as introduced by Furtula et al. in 2013 and 2019, for hydrocarbons with up to 20 carbon atoms. Finally, we investigate the relationships between graph energies of acyclic hydrocarbons compared to their cyclic versions.
In Vivo Skin Hydrating Efficacy of Fish Collagen from Greenland Halibut as a High-Value Active Ingredient for Cosmetic Applications
Authors: Martins Eva , Reis Rui L. , Silva Tiago H.
Published: January 2023

The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels.
Evaluation of the Hybrid Membrane of ZnO Particles Supported in Cellulose Acetate for the Removal of Lead
Authors: Pérez-Silva Irma , Páez-Hernández Ma. Elena , Ibarra Israel S. , Camacho-Mendoza Rosa Luz
Published: January 2023

Water polluted by discarded heavy metals such as lead is creating a global pollution problem. In this work, adsorption of Pb(II) was realized in batch studies by a hybrid membrane of cellulose acetate with ZnO particles. First, ZnO particles were prepared by precipitation and immobilized on the membrane. The hybrid membrane was elaborated by interfacial polymerization. The structure and surface were characterized based on Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Batch experiments were carried out under different conditions where the number of particles of ZnO present in the membrane and the pH of the aqueous solution were varied. The Langmuir and Freundlich isotherm models were evaluated in the best adsorption conditions. Data fitted well with a Langmuir model with a maximum adsorption capacity of 15.55 mg·g−1, which was similar for this type of materials. Thermodynamic parameters such as Gibbs free energy, enthalpy, and entropy showed that the process was spontaneous and favorable. The hybrid membrane was evaluated in simulated wastewater of the battery industry with a superior efficiency of up to 97%; without the medium, it did not generate interference. These results suggest that Pb(II) removal by hybrid membrane is possible.
Creep Aging Behavior of a Thermo-Mechanical Treated 7B04 Aluminum Alloy
Authors: Lao Shanfeng , Zhan Lihua , Qian Wei , Xu Yongqian , Ma Bolin , Liu Chuhui , Huang Minghui , Yang Youliang , Chen Kuigen , Peng Nanhui , Gao Tuanjie , Xi Hongfei
Published: January 2023

Creep aging behavior of a pre-strain and under-age treated 7B04 aluminum alloy (7B04-P for short) was systematically investigated under different temperatures and applied stresses. A lot of dislocation tangles and η’/GPzs were formed in the Al matrix of the 7B04-P al alloy. With the increase in temperature and applied stress, the total creep strain and steady-state creep rate increased significantly. However, the mechanical properties of creep-aged 7B04-P al alloy are sensitive to temperature rather than applied stress. The age-hardening precipitates and grain boundaries change obviously when the temperature rises to 160 °C. Compare to the low temperature (less than 160 °C) creep-aged samples, the size of precipitates is much larger, the width of PFZ is broader, and the grain boundary precipitates are more discontinuous and coarsen. As expected, the electrical conductivity is improved after the high-temperature creep aging process at 160 °C. Last but not least, the creep deformation of 7B04-P al alloy almost retains that of AA7B04-T7451. Meanwhile, the mechanical properties after the creep aging process of 7B04-P al alloy are better than that of AA7B04-T7451. It can be suggested that the novel high-temperature creep age forming of the thermo-mechanical treated 7B04 aluminum alloy can enhance the forming efficiency and comprehensive properties for aerospace industries.
Aluminum Scrap to Hydrogen: Complex Effects of Oxidation Medium, Ball Milling Parameters, and Copper Additive Dispersity
Authors: Buryakovskaya Olesya A. , Suleimanov Musi Zh. , Vlaskin Mikhail S. , Kumar Vinod , Ambaryan Grayr N.
Published: January 2023

An effective combination of oxidation medium, ball milling parameters, and copper additive disperstiy ensuring fast aluminum scrap reaction with high hydrogen yield, was suggested. Different milling parameters (5, 10, and 15 mm steel balls; 1 and 2 h; unidirectional and bidirectional rotation modes) were tested for Al-10 wt.% Cu (50–70 μm) composition. The samples milled with 5 (2 h) and 10 mm (1 and 2 h) balls contained undesirable intermetallic phases Al2Cu and Cu9Al4, while those activated with 15 mm balls (1 h) provided the second-finest powder and best preservation of the original Cu and Al phases. Among the tested (at 60 °C) 2 M solutions NaCl, LiCl, KCl, MgCl2, ZnCl2, BaCl2, CaCl2, NiCl2, CoCl2, FeCl2, and AlCl3, the first six appeared to be almost useless (below 4% hydrogen yield), the following four provided better results, and the ultimate 91.5% corresponded to AlCl3. Samples with Cu dispersity of 50–100 nm, 1–19, 50–70, and 150–250 μm, and with no additive, were milled under the optimal parameters and tested in AlCl3. Their total yields were similar (~90–94%), while reaction rates differed. The highest rate was obtained for the sample modified with 50–70 μm powder.
Yield of Annealing on the Properties of the Ti-5Al-2.5Fe Alloy Produced by Powder Forging
Authors: Jia Mingtu , Alshammari Yousef , Yang Fei , Bolzoni Leandro
Published: January 2023

The high cost of titanium alloys can be reduced using alternative manufacturing techniques and using cheap alloying elements. In this study, the Ti-5Al-2.5Fe alloy, a cheaper α + β alloy than the workhorse Ti-6Al-4V, was produced by powder metallurgy combined with hot thermomechanical deformation by means of forging. The forged alloy was subsequently subjected to a heat treatment at 750 °C for several annealing times in order to modify the microstructure and tailor the mechanical properties. This study demonstrates that, regardless of the forging temperature used, annealing of the forged Ti-5Al-2.5Fe alloy improves both the strength and the ductility. Generally, the longer the annealing time, the higher the gain in strength and ductility with respect to the forged alloy. Moreover, annealing is significantly more beneficial to improve the ductility rather than the strength of the powder-forged Ti-5Al-2.5Fe alloy.
Corrosion-Resistant Coating Based on High-Entropy Alloys
Authors: Lin Cheng , Yao Yonggang
Published: January 2023

Metal corrosion leads to serious resource waste and economic losses, and in severe cases, it can result in catastrophic safety incidents. As a result, proper coatings are often employed to separate metal alloys from the ambient environment and thus prevent or at least slow down corrosion. Among various materials, high-entropy alloy coatings (HEA coating) have recently received a lot of attention due to their unique entropy-stabilized structure, superior physical and chemical properties, and often excellent corrosion resistance. To address the recent developments and remaining issues in HEA coatings, this paper reviews the primary fabrication methods and various elemental compositions in HEA coatings and highlights their effects on corrosion resistance properties. It is found that FeCoCrNi-based and refractory high-entropy alloy coatings prepared by the laser/plasma cladding method typically show better corrosion resistance. It also briefly discusses the future directions toward high-performing corrosion-resistant coatings based on HEA design.
Raw Eggshell as an Adsorbent for Copper Ions Biosorption—Equilibrium, Kinetic, Thermodynamic and Process Optimization Studies
Authors: Marković Miljan , Gorgievski Milan , Štrbac Nada , Grekulović Vesna , Božinović Kristina , Zdravković Milica , Vuković Milovan
Published: January 2023

The study on the biosorption of copper ions using raw eggshells as an adsorbent is presented in this paper. The influence of different process parameters, such as: initial pH value of the solution, initial Cu2+ ions concentration, initial mass of the adsorbent, and stirring rate, on the biosorption capacity was evaluated. The SEM-EDS analysis was performed before and after the biosorption process. SEM micrographs indicate a change in the morphology of the sample after the biosorption process. The obtained EDS spectra indicated that K, Ca, and Mg were possibly exchanged with Cu2+ ions during the biosorption process. The equilibrium analysis showed that the Langmuir isotherm model best describes the experimental data. Four kinetic models were used to analyze the experimental data, and the results revealed that the pseudo-first order kinetic model is the best fit for the analyzed data. Calculated thermodynamic data indicated that the biosorption process is spontaneous, and that copper ions are possibly bound to the surface of the eggshells by chemisorption. The biosorption process was optimized using Response Surface Methodology (RSM) based on the Box-Behnken Design (BBD), with the selected factors: adsorbent mass, initial metal ion concentration, and contact time.
Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk?
Authors: Anagnostis Panagiotis , Kotsis Vasileios , Banach Maciej , Mikhailidis Dimitri P.
Published: January 2023

Plant sterols are molecules that are structurally similar to cholesterol and provided only as dietary sources (e.g., vegetables, fruits, nuts, cereals) since they cannot be synthesized by humans. Sterol-enriched diets (≥2 g/day) may decrease total and low-density lipoprotein cholesterol concentrations by 5–10%, either alone or when added to statins, since they antagonize dietary cholesterol absorption in the intestine. On the other hand, increased serum phytosterol concentrations, (including when associated with sitosterolemia, a rare genetic defect) may contribute to atherosclerotic risk, although a threshold for such a role has not been established. Medications such as ezetimibe may effectively reduce cholesterol and phytosterol absorption. Whether the therapeutic approach associated with the reduction of phytosterol absorption is also translated into a reduction in a patient’s residual cardiovascular risk needs to be established.
VAMS-Based Blood Capillary Sampling for Mass Spectrometry-Based Human Metabolomics Studies
Authors: Volani Chiara , Malfertheiner Christa , Caprioli Giulia , Fjelstrup Søren , Pramstaller Peter P. , Rainer Johannes , Paglia Giuseppe
Published: January 2023

Volumetric absorptive microsampling (VAMS) is a recently developed sample collection method that enables single-drop blood collection in a minimally invasive manner. Blood biomolecules can then be extracted and processed for analysis using several analytical platforms. The integration of VAMS with conventional mass spectrometry (MS)-based metabolomics approaches is an attractive solution for human studies representing a less-invasive procedure compared to phlebotomy with the additional potential for remote sample collection. However, as we recently demonstrated, VAMS samples require long-term storage at −80 °C. This study investigated the stability of VAMS samples during short-term storage and compared the metabolome obtained from capillary blood collected from the fingertip to those of plasma and venous blood from 22 healthy volunteers. Our results suggest that the blood metabolome collected by VAMS samples is stable at room temperature only for up to 6 h requiring subsequent storage at −80 °C to avoid significant changes in the metabolome. We also demonstrated that capillary blood provides better coverage of the metabolome compared to plasma enabling the analysis of several intracellular metabolites presented in red blood cells. Finally, this work demonstrates that with the appropriate pre-analytical protocol capillary blood can be successfully used for untargeted metabolomics studies.
Monolithically 3D-Printed Microfluidics with Embedded µTesla Pump
Authors: Duan Kai , Orabi Mohamad , Warchock Alexus , Al-Akraa Zaynab , Ajami Zeinab , Chun Tae-Hwa , Lo Joe F.
Published: January 2023

Microfluidics has earned a reputation for providing numerous transformative but disconnected devices and techniques. Active research seeks to address this challenge by integrating microfluidic components, including embedded miniature pumps. However, a significant portion of existing microfluidic integration relies on the time-consuming manual fabrication that introduces device variations. We put forward a framework for solving this disconnect by combining new pumping mechanics and 3D printing to demonstrate several novel, integrated and wirelessly driven microfluidics. First, we characterized the simplicity and performance of printed microfluidics with a minimum feature size of 100 µm. Next, we integrated a microtesla (µTesla) pump to provide non-pulsatile flow with reduced shear stress on beta cells cultured on-chip. Lastly, the integration of radio frequency (RF) device and a hobby-grade brushless motor completed a self-enclosed platform that can be remotely controlled without wires. Our study shows how new physics and 3D printing approaches not only provide better integration but also enable novel cell-based studies to advance microfluidic research.
Acknowledgment to the Reviewers of Modelling in 2022
Authors:   Modelling Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Synergistic Inhibiting Effect of Phytochemicals in Rheum palmatum on Tyrosinase Based on Metabolomics and Isobologram Analyses
Authors: Xiong Yin , Kim Hye Kyong , Özer Övgü Çelikler , van Duijn Bert , Korthout Henrie A. A. J. , Zi Lihong , Cai Ang
Published: January 2023

Tyrosinase (TYR) plays a key role in the enzymatic reaction that is responsible for a range of unwanted discoloration effects, such as food browning and skin hyperpigmentation. TYR inhibitors could, therefore, be candidates for skin care products that aim to repair pigmentation problems. In this study, we used a metabolomics approach combined with the isobologram analysis to identify anti-TYR compounds within natural resources, and evaluate their possible synergism with each other. Rheum palmatum was determined to be a model plant for observing the effect, of which seven extracts with diverse phytochemicals were prepared by way of pressurized solvent extraction. Each Rheum palmatum extract (RPE) was profiled using nuclear magnetic resonance spectroscopy and its activity of tyrosinase inhibition was evaluated. According to the orthogonal partial least square analysis used to correlate phytochemicals in RPE with the corresponding activity, the goodness of fit of the model (R2 = 0.838) and its predictive ability (Q2 = 0.711) were high. Gallic acid and catechin were identified as the active compounds most relevant to the anti-TYR effect of RPE. Subsequently, the activity of gallic acid and catechin were evaluated individually, and when combined in various ratios by using isobologram analysis. The results showed that gallic acid and catechin in the molar ratios of 9:5 and 9:1 exhibited a synergistic inhibition on TYR, with a combination index lower than 0.77, suggesting that certain combinations of these compounds may prove effective for use in cosmetic, pharmaceutical, and food industries.
A Survey on the Synthesis of Variolins, Meridianins, and Meriolins—Naturally Occurring Marine (aza)Indole Alkaloids and Their Semisynthetic Derivatives
Authors: Kruppa Marco , Müller Thomas J. J.
Published: January 2023

Marine natural products are a source of essential significance due to a plethora of highly diverse biological properties. The naturally occurring (aza)indole alkaloids variolin B (1), meridianins (2), and their synthetic hybrids meriolins (3) exhibit potent kinase inhibitory activities and have aroused considerable interest in the past two decades. Therefore, the immense demand for versatile synthetic accesses to these structures has considerably increased. This review surveys the synthetic pathways to these naturally occurring alkaloids and their semisynthetic derivatives.
Endo-Exoglucanase Synergism for Cellulose Nanofibril Production Assessment and Characterization
Authors: Ramírez Brenes Ricardo Gonzalo , Chaves Lívia da Silva , Bojorge Ninoska , Pereira Nei
Published: January 2023

A study to produce cellulose nanofibrils (CNF) from kraft cellulose pulp was conducted using a centroid simplex mixture design. The enzyme blend contains 69% endoglucanase and 31% exoglucanase. The central composite rotational design (CCRD) optimized the CNF production process by achieving a higher crystallinity index. It thus corresponded to a solid loading of 15 g/L and an enzyme loading of 0.974. Using the Segal formula, the crystallinity index (CrI) of the CNF was determined by X-ray diffraction to be 80.87%. The average diameter of the CNF prepared by enzymatic hydrolysis was 550–600 nm, while the one produced by enzymatic hydrolysis and with ultrasonic dispersion was 250–300 nm. Finally, synergistic interactions between the enzymes involved in nanocellulose production were demonstrated, with Colby factor values greater than one.
Dynamics and Processes on Laser-Irradiated Surfaces
Authors: Reif Juergen
Published: January 2023

The modification of solid surfaces via the impacts of intense laser pulses and the dynamics of the relevant processes are reviewed. We start with rather weak interactions on dielectric materials, based on non-linear absorption across the bandgap and resulting in low-level local effects like electron and individual ion emission. The role of such locally induced defects in the cumulative effect of incubation, i.e., the increase in efficiency with the increasing number of laser pulses, is addressed. At higher excitation density levels, due to easier laser–material coupling and higher laser fluence, the energy dissipation is considerable, leading to lattice destabilization, surface relaxation, ablation, and surface modification (e.g., laser-induced periodic surface structures). Finally, a short list of possible applications, namely in the field of wettability, is presented.
Acknowledgment to the Reviewers of NeuroSci in 2022
Authors:   NeuroSci Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Early Naso-Gastric Feeding and Outcomes of Anorexia Nervosa Patients
Authors: Marchili Maria Rosaria , Diamanti Antonella , Zanna Valeria , Spina Giulia , Mascolo Cristina , Roversi Marco , Guarnieri Benedetta , Mirra Gianluca , Testa Giulia , Raucci Umberto , Reale Antonino , Villani Alberto
Published: January 2023

Nutritional rehabilitation with weight restoration is an important step in patients hospitalised for anorexia nervosa (AN). Naso-gastric feeding (NGF) should be considered when oral nutrition (OF) and oral nutritional supplementation (ONS) are insufficient. We evaluated the role of NGF on short- and long-term outcomes, considering weight gain, the length of hospitalisation (LOS) and the time to relapse. We report on the characteristics of patients under 18 years of age with AN admitted to the Department of Emergency and Acceptance of the Bambino Gesù Children’s Hospital, IRCCS, Rome, between March 2019 and August 2022. Three hundred and fifteen patients were enrolled. We compared patients treated with NGF (group A) and patients without NGF (group B). Group A was characterised by a significantly lower BMI on admission and discharge, more frequent use of inpatient psychotropic therapy (IPDT) and longer hospital stay. The time to relapse was significantly longer in group A compared to group B. An early NGF setting correlates with a longer time to relapse and may be associated with a shorter LOS. A high caloric intake with a balanced nutritional formula provided by NGF allows an earlier recovery. The main advantages of this approach could be the rapid discharge of patients and a more effective psychological and social recovery.
Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis
Authors: Ding Yan , Hou Ruilin , Yu Jianqiang , Xing Chengguo , Zhuang Chunlin , Qu Zhuo
Published: January 2023

Lung cancer is the second most common cancer in the world. Cigarette smoking is strongly connected with lung cancer. Benzo[a]pyrene (BaP) and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-butanone (NNK) are the main carcinogens in cigarette smoking. Evidence has supported the correlation between these two carcinogens and lung cancer. Epidemiology analysis suggests that lung cancer can be effectively prevented through daily diet adjustments. This review aims to summarize the studies published in the past 20 years exploring dietary phytochemicals using Google Scholar, PubMed, and Web of Science databases. Dietary phytochemicals mainly include medicinal plants, beverages, fruits, vegetables, spices, etc. Moreover, the perspectives on the challenges and future directions of dietary phytochemicals for lung cancer chemoprevention will be provided. Taken together, treatment based on the consumption of dietary phytochemicals for lung cancer chemoprevention will produce more positive outcomes in the future and offer the possibility of reducing cancer risk in society.
Sex Differences in Copper Concentrations during a Sports Season in Soccer Players
Authors: Toro-Román Víctor , Muñoz Diego , Maynar-Mariño Marcos , Clemente-Gil Sara , Robles-Gil María C.
Published: January 2023

Physical training produces changes in the concentrations of trace mineral elements. Sex differences in copper (Cu) concentrations in athletes are scarce. The objectives of this study were (i) to analyze changes in intracellular (erythrocytes and platelets) and extracellular (plasma and urine) Cu concentrations during a sports season in soccer players and (ii) to analyze sex differences. A total of 46 soccer players (22 men and 24 women) participated in the study. Three assessments were performed throughout the sports season. Anthropometry, body composition, nutritional intake, physical condition, female hormones (menstrual cycle) and hematology were evaluated, as well as Cu determination (plasma, urine, erythrocytes, and platelets). Regarding longitudinal differences, there were discrepancies in plasma, urine, absolute erythrocyte, and absolute platelet Cu concentrations (p < 0.05). There were differences between sexes in Cu concentrations in urine, erythrocytes relative to cell number and in platelets relative to cell number (p < 0.05). During a sports season, there are changes in Cu concentrations in soccer players. Likewise, there could be sex differences in urinary, erythrocyte and platelet Cu concentrations.
Thousand Cankers Disease in Walnut Trees in Europe: Current Status and Management
Authors: Bracalini Matteo , Benigno Alessandra , Aglietti Chiara , Panzavolta Tiziana , Moricca Salvatore
Published: January 2023

Thousand cankers disease (TCD) is a new deadly disease in walnut trees (Juglans spp.), which is plaguing commercial plantations, natural groves, and ornamental black walnut trees (Juglans nigra) in their native and invasion areas in the US and, more recently, in artificial plantations and amenity trees in the newly-invaded areas in Europe (Italy). This insect/fungus complex arises from the intense trophic activity of the bark beetle vector Pityophthorus juglandis in the phloem of Juglans spp. and the subsequent development of multiple Geosmithia morbida cankers around beetles’ entry/exit holes. After an analysis of the main biological and ecological traits of both members of this insect/fungus complex, this review explores the options available for TCD prevention and management. Special focus is given to those diagnostic tools developed for disease detection, surveillance, and monitoring, as well as to existing phytosanitary regulations, protocols, and measures that comply with TCD eradication and containment. Only integrated disease management can effectively curtail the pervasive spread of TCD, thus limiting the damage to natural ecosystems, plantations, and ornamental walnuts.