bluuebunny/crossref_metadata_2025 huggingface dataset:
The Dynamical Coupling of Wind-Waves and Atmospheric Turbulence: A Review of Theoretical and Phenomenological Models
Authors: Ayet Alex , Chapron Bertrand
Published: October 2021

When wind blows over the ocean, short wind-waves (of wavelength smaller than 10 m) are generated, rapidly reaching an equilibrium with the overlying turbulence (at heights lower than 10 m). Understanding this equilibrium is key to many applications since it determines (i) air–sea fluxes of heat, momentum and gas, essential for numerical models; (ii) energy loss from wind to waves, which regulates how swell is generated and how energy is transferred to the ocean mixed layer and; (iii) the ocean surface roughness, visible from remote sensing measurements. Here we review phenomenological models describing this equilibrium: these models couple a turbulence kinetic energy and wave action budget through several wave-growth processes, including airflow separation events induced by breaking waves. Even though the models aim at reproducing measurements of air–sea fluxes and wave growth, some of the observed variability is still unexplained. Hence, after reviewing several state-of-the-art phenomenological models, we discuss recent numerical experiments in order to provide hints about future improvements. We suggest three main directions, which should be addressed both through dedicated experiments and theory: (i) a better quantification of the variability wind-wave growth and of the role played by the modulation of short and breaking wind-waves by long wind-waves; (ii) an improved understanding of the imprint of wind-waves on turbulent coherent structures and; (iii) a quantification of the interscale interactions for a realistic wind-wave sea, where wind-and-wave coupling processes coexist at multiple time and space scales.
Bringing the Family Logic in: From Duality to Plurality in Social Enterprises
Authors: Drencheva Andreana , Au Wee Chan
Published: October 2021

Social enterprises combine activities, processes, structures, and meanings associated with multiple institutional logics that may pose conflicting goals, norms, values, and practices. This in-depth multi-source case study of an ecological social enterprise in Malaysia reveals how the enactment of the family logic interacts with the market and ecological logics not only in conflicting but also in synergetic ways. By drawing attention to the institutional logic of the family in social entrepreneurship, this study highlights the heterogeneity of social enterprises. The findings have implications for research with social enterprises and family-owned firms in relation to the ethical obligations of these organizations and the interactions of multiple logics.
Life Satisfaction and Online-Gambling Communities: A Cross-National Study of Gambling Activities Among Young Finnish, American, South Korean and Spanish People
Authors: Koivula Aki , Oksanen Atte , Sirola Anu , Savolainen Iina , Kaakinen Markus , Zych Izabela , Paek Hye-Jin
Published: October 2021

Gambling is a potential hazard to life satisfaction, yet peer relationships online might buffer this risk. This study analyzed the ways problem gambling is associated with life satisfaction as well as the extent to which the use of online-gambling community participation and, alternatively, offline belonging affect this association. A web-based survey was conducted among people aged 15–25 in Finland (n = 1,200), the United States (n = 1,212), South Korea (n = 1,192), and Spain (n = 1,212). The main variables included life satisfaction, problem gambling measured by the South Oaks Gambling Screen, online-gambling community participation, and offline belonging. Controls included compulsive internet use, hazardous drinking, psychological distress, income, age, and gender. Linear regression models were employed with country interactions. Results showed problem gambling had a negative relationship with life satisfaction, but the association was explained by control variables. Online-gambling community participation had a positive relationship with life satisfaction, especially among pathological gamblers who had poor offline relationships. Country comparisons revealed that the direct effect of excessive gambling and the compensating effect of online-gambling communities were most prominent in Finland.
Longitudinal Associations Between Depressive Symptoms and Quality of Romantic Relationships in Late Adolescence
Authors: Joosten Daniek H. J. , Nelemans Stefanie A. , Meeus Wim , Branje Susan
Published: October 2021

While youth with higher levels of depressive symptoms appear to have lower quality romantic relationships, little is known about longitudinal associations for both men and women. Therefore, this study used longitudinal dyadic design to examine both concurrent and longitudinal associations between depressive symptoms and positive as well as negative aspects of romantic relationship quality across two waves one- or two-years apart. The sample consisted of 149 Dutch stable heterosexual couples (149 females and 142 males participated at T1) in a stable romantic relationship in late adolescence with a mean age of 20.43 years old at the first wave. Actor-Partner Interdependence models were used to examine potential bidirectional associations over time between depressive symptoms and romantic relationship quality, above and beyond potential concurrent associations and stability of the constructs over time, from the perspective of both romantic partners. Results consistently indicated that men and women who reported higher levels of depressive symptoms perceived less positive aspects (intimacy and support) and more negative aspects (conflict) in their romantic relationship over time. In addition, unexpectedly, when men and women perceived more positive relationship aspects, their partners reported higher levels of depressive symptoms over time. These findings stress that depressive symptoms can interfere with the formation of high-quality romantic relationships.
In the Aftermath of School Victimization: Links Between Authoritative School Climate and Adolescents’ Perceptions of the Negative Effects of Bullying Victimization
Authors: Gee Kevin A. , Haghighat Misha D. , Vang Tseng M. , Cooc North
Published: October 2021

Although authoritative school climate—strict, yet fair enforcement of rules alongside strong adult support—is associated with lower rates of bullying victimization, less is known about whether it influences how negatively adolescents feel after being victimized at school. Further, it is unclear whether boys and girls respond differently to an authoritative climate. Identifying ways that schools can reduce negative feelings after being bullied is important given the long term psychological ramifications of bullying that, if left unaddressed, can extend into adulthood. To address these gaps, this study examined whether authoritative school climate related to how negatively adolescents felt about their schoolwork, relationships, physical health and self-perception after being bullied. Differences between boys and girls were also investigated. Analyses were conducting using national data from the 2017 School Crime Supplement on a sample of 1,331 adolescents aged 12 to 18 years (Mage = 14.3 years; 59% girls). Findings from a set of ordinal regression models with a robust set of student, parent and school controls demonstrated that adolescents in more supportive schools were less likely to report that bullying victimization negatively impacted their schoolwork and feelings about themselves. Similar results were found for girls but not boys. By investing in supportive school climates, schools can be potentially transformative places where adolescents, especially girls, can feel more positively about themselves despite being bullied.
Molecular typing and epidemiologic profiles of human metapneumovirus infection among children with severe acute respiratory infection in Huzhou, China
Authors: Ji Lei , Chen Liping , Xu Deshun , Wu Xiaofang
Published: October 2021

Background

Human metapneumovirus (hMPV) is one of the important pathogens in infant respiratory tract infection. However, the molecular epidemiology of hMPV among children < 14 years of age hospitalized with severe acute respiratory infection (SARI) is unclear. We investigated the hMPV infection status and genotypes of children hospitalized with SARI from January 2016 to December 2020 in Huzhou, China.

Methods

A nasopharyngeal flocked swab, nasal wash, or nasopharyngeal swab/or opharyngeal swab combination sample was collected from children with SARI in Huzhou from January 2016 to December 2020. Quantitative reverse transcription-polymerase chain reaction was performed to detect hMPV RNA. The hMPV F gene was amplified and sequenced, followed by analysis using MEGA software (ver. 7.0). Epidemiological data were analyzed using Microsoft Excel 2010 and SPSS (ver. 22.0) software.

Results

A total of 1133 children with SARI were recruited from 2016 to 2020. Among them, 56 (4.94%) were positive for hMPV-RNA. Children < 5 years of age accounted for 85.71% of the positive cases. The hMPV incidence was high in spring and winter, especially in December and January to March. Phylogenetic analysis of the F-gene sequences of 28 hMPV strains showed that the A1, B1, and B2 genotypes were prevalent in Huzhou, and the dominant hMPV genotype varied according to surveillance year.

Conclusions

HMPV is an important respiratory pathogen in children in Huzhou, with a high incidence in winter and spring in children < 5 years of age. In this study, genotypes A1, B1, and B2 were the most prevalent.
Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions
Authors: Hanke Nina , Gómez-Mantilla José David , Ishiguro Naoki , Stopfer Peter , Nock Valerie
Published: October 2021

Purpose

To build a physiologically based pharmacokinetic (PBPK) model of the clinical OATP1B1/OATP1B3/BCRP victim drug rosuvastatin for the investigation and prediction of its transporter-mediated drug-drug interactions (DDIs).

Methods

The Rosuvastatin model was developed using the open-source PBPK software PK-Sim®, following a middle-out approach. 42 clinical studies (dosing range 0.002–80.0 mg), providing rosuvastatin plasma, urine and feces data, positron emission tomography (PET) measurements of tissue concentrations and 7 different rosuvastatin DDI studies with rifampicin, gemfibrozil and probenecid as the perpetrator drugs, were included to build and qualify the model.

Results

The carefully developed and thoroughly evaluated model adequately describes the analyzed clinical data, including blood, liver, feces and urine measurements. The processes implemented to describe the rosuvastatin pharmacokinetics and DDIs are active uptake by OATP2B1, OATP1B1/OATP1B3 and OAT3, active efflux by BCRP and Pgp, metabolism by CYP2C9 and passive glomerular filtration. The available clinical rifampicin, gemfibrozil and probenecid DDI studies were modeled using in vitro inhibition constants without adjustments. The good prediction of DDIs was demonstrated by simulated rosuvastatin plasma profiles, DDI AUClast ratios (AUClast during DDI/AUClast without co-administration) and DDI Cmax ratios (Cmax during DDI/Cmax without co-administration), with all simulated DDI ratios within 1.6-fold of the observed values.

Conclusions

A whole-body PBPK model of rosuvastatin was built and qualified for the prediction of rosuvastatin pharmacokinetics and transporter-mediated DDIs. The model is freely available in the Open Systems Pharmacology model repository, to support future investigations of rosuvastatin pharmacokinetics, rosuvastatin therapy and DDI studies during model-informed drug discovery and development (MID3).
Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis
Authors: Upadhyay Parth J. , Vet Nienke J. , Goulooze Sebastiaan C. , Krekels Elke H. J. , de Wildt Saskia N. , Knibbe Catherijne A. J.
Published: October 2021

Aim

In critically ill mechanically ventilated children, midazolam is used first line for sedation, however its exact sedative effects have been difficult to quantify. In this analysis, we use parametric time-to-event (PTTE) analysis to quantify the effects of midazolam in critically ill children.

Methods

In the PTTE analysis, data was analyzed from a published study in mechanically ventilated children in which blinded midazolam or placebo infusions were administered during a sedation interruption phase until, based on COMFORT-B and NISS scores, patients became undersedated and unblinded midazolam was restarted. Using NONMEM® v.7.4.3., restart of unblinded midazolam was analysed as event. Patients in the trial were divided into internal and external validation cohorts prior to analysis.

Results

Data contained 138 events from 79 individuals (37 blinded midazolam; 42 blinded placebo). In the PTTE model, the baseline hazard was best described by a constant function. Midazolam reduced the hazard for restart of unblinded midazolam due to undersedation by 51%. In the blinded midazolam group, time to midazolam restart was 26 h versus 58 h in patients with low versus high disease severity upon admission (PRISM II < 10 versus > 21), respectively. For blinded placebo, these times were 14 h and 33 h, respectively. The model performed well in an external validation with 42 individuals.

Conclusion

The PTTE analysis effectively quantified the effect of midazolam in prolonging sedation and also the influence of disease severity on sedation in mechanically ventilated critically ill children, and provides a valuable tool to quantify the effect of sedatives.

Clinical trial number and registry URL: Netherlands Trial Register, Trial NL1913 (NTR2030), date registered 28 September 2009 https://www.trialregister.nl/trial/1913.
Accounting for uncertainty: an application of Bayesian methods to accruals models
Authors: Breuer Matthias , Schütt Harm H.
Published: October 2021

We provide an applied introduction to Bayesian estimation methods for empirical accounting research. To showcase the methods, we compare and contrast the estimation of accruals models via a Bayesian approach with the literature’s standard approach. The standard approach takes a given model of normal accruals for granted and neglects any uncertainty about the model and its parameters. By contrast, our Bayesian approach allows incorporating parameter and model uncertainty into the estimation of normal accruals. This approach can increase power and reduce false positives in tests for opportunistic earnings management as a result of better estimates of normal accruals and more robust inferences. We advocate the greater use of Bayesian methods in accounting research, especially since they can now be easily implemented in popular statistical software packages.
Implementing the Variability of Crystal Surface Reactivity in Reactive Transport Modeling
Authors: Prill Torben , Fischer Cornelius , Gavrilenko Pavel , Iliev Oleg
Published: October 2021

Current reactive transport model (RTM) uses transport control as the sole arbiter of differences in reactivity. For the simulation of crystal dissolution, a constant reaction rate is assumed for the entire crystal surface as a function of chemical parameters. However, multiple dissolution experiments confirmed the existence of an intrinsic variability of reaction rates, spanning two to three orders of magnitude. Modeling this variance in the dissolution process is vital for predicting the dissolution of minerals in multiple systems. Novel approaches to solve this problem are currently under discussion. Critical applications include reactions in reservoir rocks, corrosion of materials, or contaminated soils. The goal of this study is to provide an algorithm for multi-rate dissolution of single crystals, to discuss its software implementation, and to present case studies illustrating the difference between the single rate and multi-rate dissolution models. This improved model approach is applied to a set of test cases in order to illustrate the difference between the new model and the standard approach. First, a Kossel crystal is utilized to illustrate the existence of critical rate modes of crystal faces, edges, and corners. A second system exemplifies the effect of multiple rate modes in a reservoir rock system during calcite cement dissolution in a sandstone. The results suggest that reported variations in average dissolution rates can be explained by the multi-rate model, depending on the geometric configurations of the crystal surfaces.
Natural regeneration responses to thinning and burning treatments in ponderosa pine forests and implications for restoration
Authors: Wasserman Tzeidle N. , Waltz Amy E. M. , Roccaforte John Paul , Springer Judith D. , Crouse Joseph E.
Published: October 2021

Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment, but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition. A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United States. The focus was on site-specific variability in pine regeneration dynamics, temporal trends in regeneration presence and abundance, and response to treatment as described in the current literature using 29 studies that met our evidence-based review protocols. Data showed that the effects of thinning and burning treatments on regeneration depended on time since treatment. Mechanical thinning, prescribed burning, and thinning plus burn treatments all increased seedling density, but there was high variability among sites and studies. There were mixed results in the short-term (< 10 years) with both increasing and decreasing regeneration, and a general increase in regeneration 11 − 20 years post-treatment. Some long-term studies (> 20 years) concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments applied. Several studies showed the average ponderosa pine seedling presence, survival and growth found in today’s forests to be at a high density; this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.
Development and Validation of a Short Questionnaire on Dietary and Physical Activity Habits for Patients Submitted to Bariatric Endoscopic Therapies
Authors: Miranda-Peñarroya Gemma , Vallejo-Gracia Marta , Ruiz-León Ana-Maria , Saenger-Ruiz Fernando , Sorio-Fuentes Ricardo , Izquierdo-Pulido Maria , Farran-Codina Andreu
Published: October 2021

Purpose

Individuals with obesity frequently regain weigh after endoscopic bariatric therapies (EBT) unless they adhere to healthy habits. The objective was to create and validate a short, self-administered questionnaire (EMOVE) to assess healthy dietary and physical activity (PA) habits’ adherence to be used in clinical practice.

Materials and Methods

In this prospective, unicentric study, 463 patients completed the short, Spanish EMOVE questionnaire, to be validated following the Medical Outcome Trust Criteria. Conceptual and measurement model, reliability (internal consistency and test–retest [subgroup of 93 patients]), construct validity, responsiveness, interpretability, and burden were evaluated. Patients enrolled from January 2017 through August 2018 and auto-filled the EMOVE at baseline and at 3, 6, and 12 months.

Results

Patients submitted to intragastric ballon for 6 and 12 months or POSE were 82.7% women with a mean age of 42.7 years, and a mean BMI of 37.1 kg/m2. Four factors were extracted with exploratory factor analysis related to intake frequency, portions and proportions, time and place of eating, and physical activity. EMOVE showed adequate internal consistency (α = 0.73), very good test–retest (r = 0.91, CI: 0.86–0.94; p < 0.001), moderate construct validity of dietary (r = 0.24, CI: 0.11–0.37, p < 0.001), and PA habits (r = 0.44, CI 0.30–0.58; p < 0.001). Stable responsiveness, with correlations from 0.29 to 0.39 (p < 0.001) between the EMOVE scores and the % of total weight loss at 3, 6, and 12 months. Participants categorized as having good or excellent habits (score ≥ 30 points) lost significantly more weight (p < 0.05). Finally, the administration burden was 2.96 min.

Conclusion

The EMOVE is a useful tool in Spanish language to easily assess the level of adherence to healthy dietary and PA habits to be used routinely in clinical practice.

Graphical abstract
Systemic Therapy for Metastatic Pancreatic Cancer
Authors: Ettrich Thomas J. , Seufferlein Thomas
Published: October 2021

Opinion statement

Pancreatic cancer is mainly diagnosed at an advanced, often metastatic stage and still has a poor prognosis. Over the last decades, chemotherapy of metastatic pancreatic cancer (mPDAC) has proven to be superior to a mere supportive treatment with respect to both survival and quality of life. Recently, even sequential treatment of mPDAC could be established. Options for first-line treatment are combination chemotherapy regimens such as FOLFIRINOX and gemcitabine plus nab-paclitaxel when the performance status of the patient is good. For patients with poorer performance status, gemcitabine single-agent treatment is a valid option. Recently, the PARP inhibitor olaparib has been demonstrated to improve progression-free survival when used as a maintenance treatment in the subgroup of patients with mPDAC and a BRCA1/-2 germ line mutation having received at least 16 weeks of platinum-based chemotherapy. This group of patients also benefits from platinum-based chemotherapy combinations. Therefore, the BRCA1/-2 stats should be examined early in patients with mPDAC even when the occurrence of these mutations is only about 5% in the general Caucasian population. After the failure of first-line treatment, patients should be offered a second-line treatment if their ECOG permits further treatment. Here, the combination of 5-FU/FA plus nanoliposomal irinotecan has shown to be superior to 5-FU/FA alone with respect to overall survival. Immune checkpoint inhibitors like PD1/PD-L1 mAbs are particularly efficacious in tumors with high microsatellite instability (MSI-h). Limited data in mPDACs shows that only a part of the already small subgroup of MSI-H mPDACs (frequency about 1%) appears to benefit substantially from a checkpoint inhibitor treatment. The identification of further subgroups, e.g., tumors with DNA damage repair deficiency, gene fusions, as well as novel approaches such as tumor-organoid-informed treatment decisions, may further improve therapeutic efficacy.
Shear orientation of nematic phases of clay nanosheets: processing of barrier coatings
Authors: Röhrl Maximilian , Mettke Judith H. , Rosenfeldt Sabine , Schmalz Holger , Mansfeld Ulrich , Timmins Renee L. , Habel Christoph , Breu Josef , Durst Franz
Published: October 2021

When suspensions are exposed to shear forces, the particles may form ordered structures depending on their shapes, concentrations, and the material. For some processes, e.g., for wet-film coating, it is important to know how fast these structures form in shear fields and for how long the structures persist when the shear is relaxed. To obtain information on the particle structure formation and the decay time, the effective viscosity of nematic suspensions of Na-hectorite nanosheets was investigated by rheology employing a cone-plate measurement geometry. The necessary time for the formation textured nematic films could be deduced by carrying out effective viscosity measurements at constant time steps. Information could also be obtained on the lifetime of the platelet textures when shear is relaxed. All this information was employed to identify geometrical requirements for slot dies to produce barrier liners with nanosheet layers oriented parallel to PET substrates. Thereby, we obtained green and simple coatings that are in line with state-of-the-art high-performance materials such as metalized plastic foils in terms of oxygen barrier properties.
Acromegaly disease activity according to ACRODAT®, a cross-sectional study in Spain: ACROVAL study
Authors: Marazuela Mónica , Blanco Concepción , Bernabeu Ignacio , Menendez Edelmiro , Villar Rocío , Paja Miguel , Sampedro-Nuñez Miguel , Samaniego M. Luz , Díaz-Muñoz Marcos , Sánchez-Cenizo Laura
Published: October 2021

Objectives

To evaluate disease activity status using the Acromegaly Disease Activity Tool (ACRODAT®) in a cohort of Spanish acromegaly patients, to assess the relationship between the level of disease activity according to both ACRODAT®and the physicians’ clinical evaluation, and to study the potential discrepancies in the perception of symptoms between physicians and patients.

Design

Multicenter, observational, descriptive and cross-sectional study.

Methods

Disease activity was assessed in adult patients with acromegaly under pharmacological treatment during at least 6 months using ACRODAT®.

Results

According to ACRODAT®, 48.2%, 31.8% and 20.0% of a total of 111 patients were classified as having a stable disease (S), mild disease activity (M-DA) and significant disease activity (S-DA) respectively. ACRODAT®classification of disease activity significantly correlated with physicians’ opinion, with a moderate inter-rater agreement and a specificity of 92.45% (PPV = 86.21%). No correlation was found between IGF-I levels and severity of symptoms or quality of life (QoL). A decision to take clinical action was significantly more frequent in S-DA and M-DA patients than S patients but no action was taken on 5 (22.7%) and 27 (77.1%) S-DA and M-DA patients, respectively

Conclusions

ACRODAT®detected disease activity in 51.8% of patients. Interestingly, although M-DA and S-DA patients were likely to be in the process of being controlled, action was not always taken on these patients. ACRODAT®is a validated and highly specific tool that may be useful to routinely monitor acromegaly and to identify patients with non-obvious disease activity by incorporating “patient-centred” parameters like symptoms and QoL to the clinical evaluation of acromegaly.
Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group
Authors: Guirado M. , Sanchez-Hernandez A. , Pijuan L. , Teixido C. , Gómez-Caamaño A. , Cilleruelo-Ramos Á.
Published: October 2021

Multidisciplinary care is needed to decide the best therapeutic approach and to provide optimal care to patients with lung cancer (LC). Multidisciplinary teams (MDTs) are optimal strategies for the management of patients with LC and have been associated with better outcomes, such as an increase in quality of life and survival. The Spanish Lung Cancer Group has promoted this review about the current situation of the existing national LC-MDTs, which also offers a set of excellence requirements and quality indicators to achieve the best care in any patient with LC. Time and sufficient resources; leadership; administrative and institutional support; and recording of activity are key factors for the success of LC-MDTs. A set of excellence requirements in terms of staff, resources and organization of the LC-MDT have been proposed. At last, a list of quality indicators has been agreed to achieve and measure the performance of current LC-MDTs.
Valorization of granite micronized stones wastes for eco-friendly production of fired clay bricks
Authors: Ngayakamo Blasius , Komadja Gbetoglo Charles , Bello Abdulhakeem , Onwualu Azikiwe Peter
Published: October 2021

Construction and mining industries around the globe have been criticized for production of enormous solid wastes that have potential environmental impacts. Therefore, this study presents a feasible approach to recover and utilize granite micronized stones waste for production of eco-friendly bricks. This research work, aimed at substituting a natural clay with granite powder to produce value-added bricks with pronounced physical–mechanical properties. The micronized granite waste stones were crushed and ground to obtain a fine powder sample. Thereafter, different batch compositions containing a varied proportions of granite powder were prepared and fired at different sintering temperatures: 900, 1000 and 1100 °C. The raw materials and bricks were characterized for their chemical compositions, microstructural, mineralogical and physical–mechanical properties. The results showed that, an increase in granite waste powder and sintering temperature enhanced the quality of fired clay bricks in terms of mechanical strength and decreased simultaneously the apparent porosity and water absorption. The final experimental approach showed that, the possibility to produce eco-friendly bricks containing up to 30 wt% of granite powder with enhanced engineering properties fired at 1100 °C is promising.

Graphic abstract
Phase-Transition Process in the Hydrothermal Zeolitization of Volcanic Ash into LTA and FAU Structures
Authors: Monzón Jorge D. , Gonzalez Maximiliano R. , Muñoz Mercedes , Pereyra Andrea M. , Basaldella Elena I.
Published: October 2021

Minerals such as quartz, present widely in various volcanic ashes, remain unaltered throughout the low-temperature hydrothermal process currently used in industry to obtain zeolites, causing an incomplete hydrothermal transformation of the starting solid. This study presents a novel and cost-effective procedure which improves the reactivity of ash toward the generation of zeolite by increasing the availability of silica and alumina components. This method leads to a final product with a large zeolite content. The transformation consisted of an ash-activation step followed by hydrothermal zeolitization. The influence of the structural, chemical, and morphological characteristics of the volcanic ash as well as the effect of the activation procedure on the ash reactivity were studied. A collected sample (VA) and an amorphous fraction obtained after VA sieving (VA40, retained on #40 mesh) were used for zeolite production. These solids were alkaline-treated separately, aged, and reacted under controlled conditions of temperature at autogenous pressure. Throughout the process, the solid phases were characterized by X-ray diffraction, energy dispersive X-ray microanalysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, and N2adsorption-desorption porosimetry measurements. After activation and alkaline aging, the presence of quartz and plagioclase minerals in the natural ash seemed to improve the growth of NaAlSiO4 polymorphs, which in turn were transformed easily to zeolite structures. Even under adequate pretreatment and suitable synthesis conditions, the coarse non-crystalline fraction led to low conversion, while the highest conversions to zeolites A and X were obtained from the natural ash. The outcomes of the present study could be used to improve the conversion levels of other non-conventional aluminosiliceous minerals into zeolites.
Stahl's Illustrated Anxiety, Stress, and PTSD
Authors: Stahl Stephen M. , Grady Meghan M. , Muntner Nancy
Published: October 2021

The Stahl's Illustrated books are a series of pocket-sized, mid-priced, themed volumes. They distil theoretical information from the Stahl's Essential Psychopharmacology volume and combine this with practical data from The Prescriber's Guide. They are illustration heavy and designed to encourage speedy learning of both concepts and applications. The visual learner will find that these books make the concepts easier to master, and the non-visual learner will appreciate the clear, shortened text on complex psychopharmacological concepts. This volume covers the latest developments in our understanding of post-traumatic stress disorder and anxiety. As well as covering the full range of management options, there is a specific focus on the implications for military populations. The Stahl's Illustrated series appeals to the widest possible audience of mental health professionals, and not just those with expertise in psychopharmacology.
Slices of parameter space for meromorphic maps with two asymptotic values
Authors: CHEN TAO , JIANG YUNPING , KEEN LINDA
Published: October 2021

This paper is part of a program to understand the parameter spaces of dynamical systems generated by meromorphic functions with finitely many singular values. We give a full description of the parameter space for a specific family based on the exponential function that has precisely two finite asymptotic values and one attracting fixed point. It represents a step beyond the previous work by Goldberg and Keen [The mapping class group of a generic quadratic rational map and automorphisms of the 2-shift.Invent. Math.101(2) (1990), 335–372] on degree two rational functions with analogous constraints: two critical values and an attracting fixed point. What is interesting and promising for pushing the general program even further is that, despite the presence of the essential singularity, our new functions exhibit a dynamic structure as similar as one could hope to the rational case, and that the philosophy of the techniques used in the rational case could be adapted.
Boundary maps and maximal representations on infinite-dimensional Hermitian symmetric spaces
Authors: DUCHESNE BRUNO , LÉCUREUX JEAN , POZZETTI MARIA BEATRICE
Published: October 2021

We define a Toledo number for actions of surface groups and complex hyperbolic lattices on infinite-dimensional Hermitian symmetric spaces, which allows us to define maximal representations. When the target is not of tube type, we show that there cannot be Zariski-dense maximal representations, and whenever the existence of a boundary map can be guaranteed, the representation preserves a finite-dimensional totally geodesic subspace on which the action is maximal. In the opposite direction, we construct examples of geometrically dense maximal representation in the infinite-dimensional Hermitian symmetric space of tube type and finite rank. Our approach is based on the study of boundary maps, which we are able to construct in low ranks or under some suitable Zariski density assumption, circumventing the lack of local compactness in the infinite-dimensional setting.
Teacher knowledge of anxiety and use of anxiety reduction strategies in the classroom
Authors: Ginsburg Golda S. , Pella Jeffrey E. , Ogle Robert R. , DeVito Anneliese , Raguin Katherine , Chan Grace
Published: October 2021

The current study examined elementary (or primary) school teachers’ knowledge of student anxiety and evidence-based anxiety reduction strategies, whether this knowledge was associated with their use of evidence-based anxiety reduction strategies in the classroom, and correlates of teacher knowledge and use of anxiety reduction strategies in the classroom. Fifty-one volunteer elementary teachers (98% female; 98% White) participated and completed questionnaires about: themselves and work-related factors (e.g., years of teaching experience, self-efficacy), knowledge of student anxiety and anxiety treatment (e.g., core manifestations of anxiety such as physiological arousal, behavioural avoidance, and anxious thoughts), and use of anxiety reduction strategies in the classroom (e.g., relaxation strategies, encouraging the use of coping self-talk, and gradual exposure to feared situations). Results indicated that the average score on the knowledge assessment was 57% and knowledge levels were unrelated to self-reported use of anxiety reduction strategies. The most robust correlate of knowledge of anxiety and use of anxiety reduction strategies was teachers’ perceived personal accomplishment. Findings suggest additional teacher training to increase knowledge about student anxiety and use of evidence-based anxiety reduction strategies in the classroom is warranted.
Why Did Projectile-Point Size Increase in the Andean Altiplano Archaic? An Experimental Atlatl Analysis
Authors: Chen Caleb K. , Flores-Blanco Luis , Haas Randall
Published: October 2021

Archaic projectile points from the Andean Altiplano exhibit a curious trend of increasing size over time, in contrast to a well-documented size reduction throughout North America. Although a number of hypotheses exist to account for decreasing projectile-point size, there are currently no explicit explanations for increasing size. We consider several hypotheses and interrogate two techno-economic hypotheses. We posit that increasing point size compensated for lost dart momentum or accuracy that resulted from the shortening of atlatls or atlatl darts as wood became increasingly scarce on the tree-sparse Altiplano. We evaluate these hypotheses using a replicated Andean atlatl system in ballistic trials. Contrary to expectation, results show that point enlargement significantly reduces penetration depth, allowing us to confidently reject the momentum hypothesis. Point enlargement, in contrast, tentatively correlates positively with accuracy. Our experiment further shows that camelid bone is an effective and economical alternative to wood for atlatl production. Despite suboptimal lengths, camelid radioulna atlatls have a convenient morphology that requires low production time, which helps explain empirically observed camelid bone atlatls from the Andean highlands. More generally, our observations lead us to consider that central tendencies in archaeologically observed projectile-point size may reflect a trade-off between penetration and accuracy.
The triangular self in the social media era
Authors: Wang Qi
Published: October 2021

I propose a triangular theory of self to characterise the sense of selfhood in the era of social media. According to the theory, the self in the social media era comprises the represented self that is located in the private mind of the person, the registered self that is presented on social media platforms, and the inferred self that is constructed by the virtual audience. The three components of the self interact in dynamic ways to constitute a sense of selfhood and identity specific to the social media era. Autobiographical memory plays a critical role in the development and maintenance of these components. The triangular theory of self introduces new ways to understand and study memory and self in a digitally mediated world.
Harmonic generation in the interaction of laser with a magnetized overdense plasma
Authors: Maity Srimanta , Mandal Devshree , Vashistha Ayushi , Goswami Laxman Prasad , Das Amita
Published: October 2021

The mechanism of harmonic generation in both O- and X-mode configurations for a magnetized plasma has been explored here in detail with the help of particle-in-cell simulations. A detailed characterization of both the reflected and transmitted electromagnetic radiation propagating in the bulk of the plasma has been carried out for this purpose. The efficiency of harmonic generation is shown to increase with the incident laser intensity. A dependency of harmonic efficiency has also been found on magnetic field strength. This work demonstrates that there is an optimum value of the magnetic field at which the efficiency of harmonic generation maximizes. The observations are in agreement with theoretical analysis. For the O-mode configuration, this is compelling as the harmonic generation provides for a mechanism by which laser energy can propagate inside an overdense plasma region.
Do social factors influence perceptions of the jaguar Panthera onca in Ecuador?
Authors: Álvarez Hernán G. , Zapata-Ríos Galo
Published: October 2021

In Latin America, the jaguar Panthera onca is one of the most persecuted and hunted carnivores as a result of its depredation of livestock. In north-west Ecuador jaguar populations are highly threatened, and the largest known population (20–30 individuals) is in El Pambilar Wildlife Refuge, a wet tropical forest surrounded by degraded forests and an agricultural matrix. As the killing of jaguars is one of the main threats to this population, its conservation depends on the perceptions and behaviour of the people living in this region. We interviewed people from 159 households (64% of the total) in eight communities in the buffer zone of the Wildlife Refuge, to examine people's perceptions of any harm caused by jaguars, and to determine the factors that influence these perceptions. In general, people perceived that jaguars caused little harm to their domestic animals or to themselves. However, our models showed that young people with a low level of formal education are the demographic group most likely to hold negative attitudes towards the jaguar, suggesting this group could potentially benefit from involvement in environmental education and awareness programmes.
Visual diplomacy in virtual summitry: Status signalling during the coronavirus crisis
Authors: Danielson August , Hedling Elsa
Published: October 2021

On 26 March 2020, the leaders of the Group of twenty major economies (G20) convened in an emergency virtual meeting to discuss the extraordinary situation facing the world. Virtual summitry provided a stark visual contrast to the traditional staging of modern multilateral diplomacy – leaders were suddenly responsible for their own staging, leaving them with new opportunities to create a favourable impression of how they, and their respective state, would be seen. Taking the disruption of virtual summitry as a starting point, we focus on the resulting new opportunities for visual diplomacy. We draw on the symbolic interactionism of Erving Goffman and we argue that status signalling in this context was based on a shared understanding of the symbols and resources that have social value in the interaction order of summit diplomacy. Based on a visual analysis of 51 photographs from the G20 video conference, we find that the visual performances during the extraordinary meeting reflected evident, but not necessarily intentional, attempts at status seeking. The article thus contributes to an increased understanding of how visual performances contribute to uphold status distinctions in multilateral diplomacy.
Congruences for critical values of higher derivatives of twisted Hasse–Weil L-functions, III
Authors: BLEY WERNER , MACIAS CASTILLO DANIEL
Published: October 2021

LetAbe an abelian variety defined over a number fieldk, letpbe an odd prime number and let$F/k$be a cyclic extension ofp-power degree. Under not-too-stringent hypotheses we give an interpretation of thep-component of the relevant case of the equivariant Tamagawa number conjecture in terms of integral congruence relations involving the evaluation on appropriate points ofAof the${\rm Gal}(F/k)$-valued height pairing of Mazur and Tate. We then discuss the numerical computation of this pairing, and in particular obtain the first numerical verifications of this conjecture in situations in which thep-completion of the Mordell–Weil group ofAoverFis not a projective Galois module.
Asymptotics for the number of standard tableaux of skew shape and for weighted lozenge tilings
Authors: Morales Alejandro H. , Pak Igor , Tassy Martin
Published: October 2021

We prove and generalise a conjecture in [MPP4] about the asymptotics of$\frac{1}{\sqrt{n!}} f^{\lambda/\mu}$, where$f^{\lambda/\mu}$is the number of standard Young tableaux of skew shape$\lambda/\mu$which have stable limit shape under the$1/\sqrt{n}$scaling. The proof is based on the variational principle on the partition function of certain weighted lozenge tilings.
Partial Least Squares Analysis of Alzheimer’s Disease Biomarkers, Modifiable Health Variables, and Cognition in Older Adults with Mild Cognitive Impairment
Authors: Stark Jessica , Palombo Daniela J. , Hayes Jasmeet P. , Hiersche Kelly J. , Hasselbach Alexander N. , Hayes Scott M. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: October 2021

Objectives:

To identify novel associations between modifiable physical and health variables, Alzheimer’s disease (AD) biomarkers, and cognitive function in a cohort of older adults with Mild Cognitive Impairment (MCI).

Methods:

Metrics of cardiometabolic risk, stress, inflammation, neurotrophic/growth factors, AD, and cognition were assessed in 154 MCI participants (Mean age = 74.1 years) from the Alzheimer’s Disease Neuroimaging Initiative. Partial Least Squares analysis was employed to examine associations among these physiological variables and cognition.

Results:

Latent variable 1 revealed a unique combination of AD biomarkers, neurotrophic/growth factors, education, and stress that were significantly associated with specific domains of cognitive function, including episodic memory, executive function, processing speed, and language, representing 45.2% of the cross-block covariance in the data. Age, body mass index, and metrics tapping basic attention or premorbid IQ were not significant.

Conclusions:

Our data-driven analysis highlights the significant relationships between metrics associated with AD pathology, neuroprotection, and neuroplasticity, primarily with tasks tapping episodic memory, executive function, processing speed, and verbal fluency rather than more basic tasks that do not require mental manipulation (basic attention and vocabulary). These data also indicate that biological metrics are more strongly associated with episodic memory, executive function, and processing speed than chronological age in older adults with MCI.
Relationship of Purpose in Life to Dementia in Older Black and White Brazilians
Authors: Wilson Robert S. , Capuano Ana W. , Sampaio Carolina , Leurgans Sue E. , Barnes Lisa L. , Boyle Patricia A. , Farfel Jose M. , Bennett David A.
Published: October 2021

Objectives:

To test the hypothesis that higher level of purpose in life is associated with lower likelihood of dementia and mild cognitive impairment (MCI) in older Brazilians.

Methods:

As part of the Pathology, Alzheimer’s and Related Dementias Study (PARDoS), informants of 1,514 older deceased Brazilians underwent a uniform structured interview. The informant interview included demographic data, the Clinical Dementia Rating scale to diagnose dementia and MCI, the National Institute of Mental Health Diagnostic Interview Schedule for depression, and a 6-item measure of purpose in life, a component of well-being.

Results:

Purpose scores ranged from 1.5 to 5.0 with higher values indicating higher levels of purpose. On the Clinical Dementia Rating Scale, 940 persons (62.1%) had no cognitive impairment, 121 (8.0%) had MCI, and 453 (29.9%) had dementia. In logistic regression models adjusted for age at death, sex, education, and race, higher purpose was associated with lower likelihood of MCI (odds ratio = .58; 95% confidence interval [CI]: .43, .79) and dementia (odds ratio = .49, 95% CI: .41, .59). Results were comparable after adjusting for depression (identified in 161 [10.6%]). Neither race nor education modified the association of purpose with cognitive diagnoses.

Conclusions:

Higher purpose in life is associated with lower likelihood of MCI and dementia in older black and white Brazilians.