bluuebunny/crossref_metadata_2025 huggingface dataset:
O acolhimento como proposta de reorganização da assistência à saúde: uma análise bibliográfica
Authors: Beck Carmem Lúcia Colomé , Minuzzi Danielle
Published: April 2020

Pesquisa bibliográfica que teve como objetivos identificar fatores positivos, dificuldades na implantação e resultados da operacionalização do acolhimento em instituições de saúde. Foram analisadas publicações de 1999 a 2005, com descritores "acolhimento, assistência á saúde e atenção primária à saúde". A pesquisa foi feita em periódicos impressos e eletrônicos nas bases de dados LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde) e SciELO (Scientif Eletronic Library Online). A análise envolveu onze artigos e os dados foram agrupados por semelhança e construídas categorias. Fatores positivos do acolhimento: universalidade do acesso; humanização da assistência; reorganização, maior resolutividade do processo de trabalho. Dificuldades: despreparo dos profissionais; modelo médico-centrado; falta de financiamento; inadequação de área física. Resultados da implantação do acolhimento: cultura em construção; organizador dos serviços; humanização da assistência. O acolhimento pode ser pilar da humanização, possibilitando vínculo e responsabilização entre trabalhadores e usuários.
Grau de adesão ao tratamento com anti-retrovirais entre indivíduos HIV positivos atendidos no Hospital Universitário de Santa Maria
Authors: Saldanha Juliana Segabinazzi , Andrade Claudia Sala , Beck Sandra Trevisan
Published: April 2020

Este estudo qualitativo avaliou, por um período de seis meses, o grau de adesão a terapia anti-retroviral, entre 898 indivíduos maiores de 15 anos, que recebem medicamentos para o controle da infecção pelo vírus da Imunodeficiência Humana (HIV), junto a farmácia de doenças infectocontagiosas, no Hospital Universitário de Santa Maria (HUSM).  A faixa etária mais prevalente da população estudada foi a de 30 - 49 anos, sendo 517 do sexo masculino (58%) e 381 do sexo feminino (42%). A maioria dos pacientes (72%) apresentou bom nível de adesão. Apenas 7% dos indivíduos abandonaram o tratamento. Conclui-se que manter uma adequada adesão ao tratamento por longo prazo, é um trabalho que necessita constante vigilância. A atenção farmacêutica e clínica no acompanhamento e tratamento da infecção pelo HIV aumentaram a expectativa e melhorou a qualidade de vida dos indivíduos avaliados.
Risk Factors for Development of Hypocalcemia in Patients With Cancer Treated With Bone-Modifying Agents
Authors: White Paul S. , Dennis Michael , Jones Eric A. , Weinberg Janice M. , Sarosiek Shayna
Published: April 2020

Background: This retrospective analysis describes the prevalence of and risk factors associated with the development of hypocalcemia in patients with cancer receiving bone-modifying agents (BMAs) as supportive care. Patients and Methods: Patients with cancer treated with an intravenous or subcutaneous BMA, including pamidronate, zoledronic acid, or denosumab, at a tertiary care/safety net hospital in 2005 through 2015 were included in this retrospective review. We reviewed the medical records for predictive clinical and laboratory parameters and for patient outcomes. Results: A total of 835 patients with cancer received at least one dose of a BMA during the specified time frame; 205 patients (25%) developed hypocalcemia of CTCAE grade ≥1 within 8 weeks of BMA initiation, 18 of whom (8.8%) had grade ≥3, and 3 patients died as a result. Multivariate analysis showed that patients with hematologic malignancy (odds ratio [OR], 1.956; P=.025), bone metastases (OR, 2.443; P=.017), inpatient status (OR, 2.592; P<.001), and deficient baseline vitamin D levels (OR, 2.546; P<.023) were more likely to develop hypocalcemia. Hypercalcemia before BMA administration (OR, 0.474; P=.032) was protective. Conclusions: Certain patient populations, including those with hematologic malignancies and/or bone metastases, warrant closer monitoring of calcium levels while receiving BMAs because of the high rate of hypocalcemia. Low pretreatment vitamin D levels are associated with the development of hypocalcemia. These data support close monitoring of calcium levels in patients with cancer receiving BMAs, in addition to adequate repletion of vitamin D before initiation of BMAs when possible.
Stretchable Textiles with Superwettabilities for Tunable Oil‐Water Separation
Authors: Lv Pin , Liu Yu‐Qing , Zhang Yong‐Lai , Ma Jia‐Nan , Han Dong‐Dong , Sun Hong‐Bo
Published: April 2020

Oil water separation plays a vital role in a series of industrial applications, such as petroleum industry and sewage treatments. However, traditional separation methods often suffer from non‐adjustable separation efficiency and solid impurities blockage. To solve this problem, we modify a commercially available stretchable textile with superwetting materials, including graphene oxide (GO) and polytetrafluoroethylene (PTFE), for tunable oil‐water separation. After GO coating, the stretchable textile shows superhydrophilicity in air and superoleophobicity underwater, which is further applied to tunable oils‐water separation via mechanical stretching. Interestingly, the superwetting textile is workable within a certain stretching degree. By tuning the pore size of the textile via stretching, the permeation rate increased by three times. The stretching property not only promotes the separation rate, but also imparts the self‐dredging property that can avoid solid impurities clogging in real case separation. The stretchable oil‐water separation textiles hold great potential for practical applications in sewage treatments.
In Situ Template‐Sacrificing Approach to a Highly Conductive 3D Hybrid Interlayer of an Advanced Lithium–Sulfur Battery Separator
Authors: Li Haiming , Lv Ruihua , Zeng Rong , Na Bing , Zhang Shuang , Liu Hesheng , Lin Shan
Published: April 2020

A highly conductive interlayer, as the dual current collector, is necessary to reutilize lithium polysulfide for better performance of lithium–sulfur batteries. Slurry coating usually results in poor conductivity owing to the insulating binders. Herein, a metal coordinated compound (Mn‐BDC) serves as the sacrificed template to induce a highly conductive polypyrrole (PPy) skeleton via in situ polymerization. Simultaneously, the decomposition of Mn‐BDC produces fine particles that are highly absorptive in the PPy skeleton. The resultant PPy hybrid interlayer, about 5 μm in thickness, can remarkably inhibit the shuttle effect and reuse the adsorbed lithium polysulfide. As a result, a high specific capacity of 517.3 mAh g−1 is achieved after 500 cycles at 0.5 C with a fading rate of 0.093% per cycle.
Internet of Things feasibility for disabled people
Authors: Vasco Lopes Nuno
Published: April 2020

Internet of Things (IoT) can make people's lives more convenient, and is particularly important for people with disabilities. The IoT technology will certainly give to people with disabilities its contribution to improve their living conditions, helping them to achieve more autonomy and independence. This work provides a taxonomy for IoT architectures and the IoT requirements when applied to help people with disabilities. Additionally, it also proposes a specific IoT architecture for disabled people. The proposed IoT architecture complies with current IoT Articles and specifications. The IoT architecture tries to encompass the perspectives of healthcare stakeholders and generic requirements that are necessary for this sort of applications. At the end, the article points out the challenges for designing IoT architectures for people with disabilities.
Geology, stratigraphy and palaeoenvironmental evolution of the Stephanorhinus kirchbergensis‐bearing Quaternary palaeolake(s) of Gorzów Wielkopolski (NW Poland, Central Europe)
Authors: Sobczyk Artur , Borówka Ryszard K. , Badura Janusz , Stachowicz‐Rybka Renata , Tomkowiak Julita , Hrynowiecka Anna , Sławińska Joanna , Tomczak Michał , Pitura Mateusz , Lamentowicz Mariusz , Kołaczek Piotr , Karpińska‐Kołaczek Monika , Tarnawski Dariusz , Kadej Marcin , Moska Piotr , Krąpiec Marek , Stachowicz Krzysztof , Bieniek Bartosz , Siedlik Krzysztof , Bąk Małgorzata , van der Made Jan , Kotowski Adam , Stefaniak Krzysztof
Published: April 2020

The sedimentary succession exposed in the Gorzów Wielkopolski area includes Eemian Interglacial (MIS 5e) or Early Weichselian (MIS 5d–e) deposits. The sedimentary sequence has been the object of intense interdisciplinary study, which has resulted in the identification of at least two palaeolake horizons. Both yielded fossil remains of large mammals, alongside pollen and plant macrofossils. All these proxies have been used to reconstruct the environmental conditions prevailing at the time of deposition, as well as to define the geological context and the biochronological position of the fauna. Optically stimulated luminescence dating of the glaciofluvial layers of the GS3 succession to 123.6 ± 10.1 (below the lower palaeolake) and 72.0 ± 5.2 ka (above the upper palaeolake) indicate that the site formed during the Middle–Late Pleistocene (MIS 6 – MIS 5). Radiocarbon‐dating of the lacustrine organic matter revealed a tight cluster of Middle Pleniglacial Period (MIS 3) ages in the range of ~41–32 ka cal bp (Hengelo – Denekamp Interstadials). Holocene organic layers have also been found, with 14C ages within a range of 4330–4280 cal bp (Neolithic). Pollen and plant macrofossil records, together with sedimentological and geochemical data, confirm the dating to the Eemian Interglacial.
Curved vertical‐alignment liquid crystal display with uniform brightness: From pixel design to verification
Authors: Cao Jie , Chen Jianhong , Du Peng , Ying Jianjian , Huang Tien‐Chun , Chen Lixuan , Zhao Bin , Zhang Xin
Published: April 2020

Curved liquid crystal display (LCD) suffers from an issue of uneven brightness among the vertical‐alignment LCD panels based on thin glass substrates. In this work, we investigated its origin through optical simulation and successfully realized uniform brilliance for 27‐inch curved LCD panels. The optical simulation revealed that the dark areas on the bending sides of the curved LCD panel originated from the reduced azimuth angle of the liquid crystals (LC) next to the ITO trunk. This issue could be resolved by decreasing the pretilt angle of the LC on the color filter side. Through developing pretilt angle tuning technologies, we experimentally verified that the uniform brilliance could be achieved for 27‐inch curved LCD panels with 900‐mm curvature on thin glass substrates.
Structure of Supramers Formed by the Amphiphile Biotin‐CMG‐DOPE
Authors: Zalygin Anton , Solovyeva Daria , Vaskan Ivan , Henry Stephen , Schaefer Marcel , Volynsky Pavel , Tuzikov Alexander , Korchagina Elena , Ryzhov Ivan , Nizovtsev Alexey , Mochalov Konstantin , Efremov Roman , Shtykova Eleonora , Oleinikov Vladimir , Bovin Nicolai
Published: April 2020

The synthetic function‐spacer‐lipid (FSL) amphiphile biotin‐CMG‐DOPE is widely used for delicate ligation of living cells with biotin residues under physiological conditions. Since this molecule has an “apolar‐polar‐hydrophobic” gemini structure, the supramolecular organization is expected to differ significantly from the classical micelle. Its organization is investigated with experimental methods and molecular dynamics simulations (MDS). Although the linear length of a single biotin‐CMG‐DOPE molecule is 9.5 nm, the size of the dominant supramer globule is only 14.6 nm. Investigations found that while the DOPE tails form a hydrophobic core, the polar CMG spacer folds back upon itself and predominantly places the biotin reside inside the globule or planar layer. MDS demonstrates that <10 % of biotin residues on the highly water dispersible globules and only 1 % of biotin residues in layer coatings are in an linear conformation and exposing biotin into the aqueous medium. This explains why in biotin‐CMG‐DOPE apolar biotin residues both in water dispersible globules and coatings on solid surfaces are still capable of interacting with streptavidin.
Lasers and Surface Functionalization
Authors: Moglia Francesca , Pozo Jose , Lasagni Andrés F.
Published: April 2020

Nature shows how special nano‐ and micrometer‐sized features can render surfaces hydrophobic or anti‐bacterial. Laser‐based texturing is a technique capable of imitating this and functionalizing surfaces without the use of additives. EU‐funded projects, such as LAMpAS, aim at achieving high throughputs with systems based on kW‐level, short and ultrashort‐pulsed lasers, enabling this technology for the competitive manufacturing and commercialization of domestic appliances with new features and fast‐moving consumer products.
Laser's Future Will Be Smart
Authors: Post Hilde‐Josephine
Published: April 2020

This year the laser is celebrating its 60th birthday, but it can by no means be regarded as anachronistic. On the contrary, the more mature laser technology becomes the more exciting and dynamic its development is. The future of the laser promises above all to be smarter, even more efficient, more powerful, more flexible and more productive. This coincides with the vision put forward by this year's top‐class International Laser Technology Congress in Aachen (AKL'20). Under the auspices of the Fraunhofer Institute for Laser Technology (ILT), laser developers, manufacturers and users will meet for the 13th time from May 6 to 8, 2020, to share their experiences. Looking forward to the conference, ILT's head of communication, Axel Bauer, reveals that “the conference agenda will include practice‐oriented research, new applications and an outlook on pioneering developments such as additive manufacturing and artificial intelligence.” For PhotonicsViews, in the run‐up to the congress, experts from research and industry have taken a look into the crystal ball of the laser's future.
The Global Market for Industrial Laser Processing
Authors: Belforte David A.
Published: April 2020

Global industrial laser revenues, over the period 2010 ‐‐ 19, show a period of strong CAGR growth (11.5 %) led by the dynamic markets for high‐power fiber lasers used in sheet metal cutting and a significant application for excimer lasers (smart phones). In 2019, global laser revenues decreased for only the first time since the recession of 2009, mainly for two reasons: unconstrained fiber laser selling price decreases and the maturation of the application for excimer lasers. Strong competition in the Chinese market ‐‐ now more than 40 % of the world market ‐‐ drove down the average selling price of industrial lasers by 17.5 % in 2019 while unit sales were up 6.5 % in the same period.
Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent
Authors: Tomiyama Ken‐ichi , Ito Norimasa , Hayashi Kenichi , Kawamoto Yuki , Shinoda Hiroaki , Katakami Nobuyuki
Published: April 2020

An oesophageal fully covered self‐expanding metallic stent (SEMS) was placed in a 54‐year‐old Japanese man to relieve dysphagia owing to a stage cT1bN3M1c lung adenocarcinoma. High expression of programmed cell death‐ligand 1 was microscopically confirmed, and pembrolizumab was subsequently administered. Several days later, the patient was hospitalized with septic shock, and severe mediastinitis and pneumonia caused by oesophageal SEMS‐induced oesophageal and bronchial perforations were observed. Thoracoscopic surgery was performed to drain the mediastinal abscess, and an additional oesophageal SEMS was placed to close the oesophageal perforation. The patient gradually recovered from the potentially fatal infection, and the SEMS was retrieved after confirming perforation closure. We re‐initiated pembrolizumab administration, and the patient responded well. The present report reveals the potential risk and effectiveness of SEMS, especially when administered with immune checkpoint inhibitors.
Simultaneous image matching for person re‐identification via the stable marriage algorithm
Authors: Hashim Nik Mohd Zarifie , Kawanishi Yasutomo , Deguchi Daisuke , Ide Ichiro , Murase Hiroshi
Published: April 2020

Recently, multiperson tracking across non‐overlapping camera views is gaining increasing attention in the video surveillance field due to its importance for public security. Most existing methods find a correspondence of person images individually across each pair of adjacent two cameras. However, in such a naive approach, redundant matching where one of the person images is selected for the matching pair for several times, often occurs. It leads to tracking failure. To overcome this problem, in this paper, by considering the matching problem as an instance of the “marriage problem” that is well known in Economics, we propose a simultaneous image matching method for multiple persons based on the stable marriage algorithm. We confirmed that the proposed method outperforms some of the existing state‐of‐the‐art methods on several well‐known public datasets. © 2020 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Perspective template matching by differential evolution introducing the group remaking
Authors: Sato Junya , Yamada Takayoshi , Ito Kazuaki , Akashi Takuya
Published: April 2020

In order to achieve correct perspective template matching on two‐dimensional general images, we propose a differential evolution (DE) introducing the group remaking. Since the perspective template matching has eight degree of freedom (DoF), acquisition of a global optimum, which is an area corresponding to a template in a target image, within limited calculation resource is difficult. In order to address this task, DE is utilized. This method can optimize some parameters simultaneously and acquire a good approximate solution within the limited calculation resources. The adopted DE divides the population into two equal groups, exploitation group for local search and exploration group for global search. By remaking the exploitation group every time, the best solution is found and updated, more effective search is possible. Also, linear group size changing scheme and initialization of parameters for crossover and mutation are introduced to acquire good performance. The experimental results using a general 2D image dataset show the lowest average error of the proposed method. © 2020 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Testing the W -exchange mechanism with two-body baryonic B decays
Authors: Hsiao Y.K. , Tsai Shang-Yuu , Lih Chong-Chung , Rodrigues Eduardo
Published: April 2020

Abstract

The role of W -exchange diagrams in baryonic B decays is poorly understood, and often taken as insignificant and neglected. We show that charmful two-body baryonic

$$ B\to {\mathbf{B}}_c\overline{\mathbf{B}}^{\prime } $$

B
→

B
c

B
¯

′

decays provide a good test-bed for the study of the W -exchange topology, whose contribution is found to be non-negligible; here B

c
is an anti-triplet or a sextet charmed baryon, and

$$ \overline{\mathbf{B}}^{\prime } $$

B
¯

′

an octet charmless (anti-)baryon. In particular, we calculate that

$$ \mathrm{\mathcal{B}}\left({\overline{B}}^0\to {\Sigma}_c^{+}\overline{p}\right)=\left({2.9}_{-0.9}^{+0.8}\right)\times {10}^{-6} $$

ℬ

B
¯

0

→

Σ
c
+

p
¯

=

2.9

−
0.9

+
0.8

×

10

−
6

in good agreement with the experimental upper bound. Its cousin

$$ {\overline{B}}_s^0 $$

B
¯

s
0

mode,

$$ {\overline{B}}_s^0\to {\Lambda}_c^{+}\overline{p} $$

B
¯

s
0

→

Λ
c
+

p
¯

, is a purely W -exchange decay, hence is naturally suited for the study of the role of the W -exchange topology. We predict

$$ \mathrm{\mathcal{B}}\left({\overline{B}}_s^0\to {\Lambda}_c^{+}\overline{p}\right)=\left(0.8\pm 0.3\right)\times {10}^{-6} $$

ℬ

B
¯

s
0

→

Λ
c
+

p
¯

=

0.8
±
0.3

×

10

−
6

, a relatively large branching ratio to be tested with a future measurement by the LHCb collaboration. Other predictions, such as

$$ \mathrm{\mathcal{B}}\left({\overline{B}}^0\to {\Xi}_c^{+}{\overline{\Sigma}}^{-}\right)=\left(1.1\pm 0.4\right)\times {10}^{-5} $$

ℬ

B
¯

0

→

Ξ
c
+

Σ
¯

−

=

1.1
±
0.4

×

10

−
5

, can be tested with future Belle II measurements.
Variability in the number of mental foramina in the African green monkey (Grivet) (Chlorocebus aethiops)
Authors: Mrożek Kamil , Marchewka Justyna , Leszczyński Bartosz , Wróbel Andrzej , Głąb Henryk
Published: April 2020

This study aimed to determine the number of mental foramina (MFs) in vervet monkeys of the Cercopithecini tribe and perform a µCT analysis of mental foramina and mandibular canal morphology. A total of 19 simian skulls belonging to Chlorocebus aethiops species were used in the analyses. An average of three mental foramina was present in most individuals from the analyzed group. The Mann–Whitney test revealed no statistically significant difference between the number of foramina on the right- and left-hand side. Likewise, no statistically significant differences between the number of MFs across sexes were observed. Correlation coefficient values between mandibular length and the ipsilateral number of MF indicate a weak and statistically non-significant (p > 0.05) linear relationship. Volumetric reconstructions revealed the presence of a single periosteal sheathed mandibular canal terminated with four small mental foramina.
Estimation of Vertical Heat Diffusivity at the Base of the Mixed Layer in the Bay of Bengal
Authors: Girishkumar M. S. , Ashin K. , McPhaden M. J. , Balaji B. , Praveenkumar B.
Published: April 2020

One approach to estimating vertical heat diffusivity (KT) is to compute it from the residual of the mixed layer (ML) heat budget. Based on this approach, we use moored buoy data at 15°N, 12°N, and 8°N along 90°E over the period of 2007–2018 to estimate the seasonal average of KT at the base of the mixed layer in the Bay of Bengal (BoB). We find that KT is lower during spring and higher during winter compared to summer and fall at the mooring locations. Moreover, KT is generally higher in the southern BoB compared to the northern BoB. The present study also shows that the seasonal and spatial variability of KT is modulated both by stratification at the base of ML and by seasonal and spatial heterogeneity in atmospheric forcing, most notably wind stress and buoyancy flux. The availability of information on the spatial and seasonal variability of KT in the BoB will facilitate evaluation and validation of turbulent mixing parameterization schemes incorporated into ocean models.
The Stuff That Psyche Is Made Of
Authors: Stanley Sarah
Published: April 2020

The metallic asteroid Psyche appears to contain more rock than previously thought, shedding new light on possible scenarios for its formation in the early solar system.
Single-shot lensless imaging with fresnel zone aperture and incoherent illumination
Authors: Wu Jiachen , Zhang Hua , Zhang Wenhui , Jin Guofan , Cao Liangcai , Barbastathis George
Published: April 2020

Lensless imaging eliminates the need for geometric isomorphism between a scene and an image while allowing the construction of compact, lightweight imaging systems. However, a challenging inverse problem remains due to the low reconstructed signal-to-noise ratio. Current implementations require multiple masks or multiple shots to denoise the reconstruction. We propose single-shot lensless imaging with a Fresnel zone aperture and incoherent illumination. By using the Fresnel zone aperture to encode the incoherent rays in wavefront-like form, the captured pattern has the same form as the inline hologram. Since conventional backpropagation reconstruction is troubled by the twin-image problem, we show that the compressive sensing algorithm is effective in removing this twin-image artifact due to the sparsity in natural scenes. The reconstruction with a significantly improved signal-to-noise ratio from a single-shot image promotes a camera architecture that is flat and reliable in its structure and free of the need for strict calibration.
Lithium intercalation edge effects and doping implications for graphite anodes
Authors: Peng Chao , Mercer Michael P. , Skylaris Chris-Kriton , Kramer Denis
Published: April 2020

The interface between the electrolyte and graphite anodes plays an important role for lithium (Li) intercalation and has significant impact on the charging/discharging performance of Lithium-Ion Batteries (LIBs).
Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane
Authors: Anton-Sales Irene , D'Antin Justin Christopher , Fernández-Engroba Jorge , Charoenrook Victor , Laromaine Anna , Roig Anna , Michael Ralph
Published: April 2020

Bacterial nanocellulose exhibits valuable properties to act as a corneal bandage material in terms of conformability, suturability, durability and ease of manipulation in ophthalmological environments.
Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications
Authors: Harberts Jann , Haferkamp Undine , Haugg Stefanie , Fendler Cornelius , Lam Dennis , Zierold Robert , Pless Ole , Blick Robert H.
Published: April 2020

Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
Impact of molecular structure on singlet and triplet exciton diffusion in phenanthroline derivatives
Authors: Rai Deepesh , Bangsund John S. , Barriocanal Javier Garcia , Holmes Russell J.
Published: April 2020

Systematic investigation of singlet and triplet exciton diffusion with changes in molecular structure and intermolecular separation for phenanthroline derivatives.
Focused Stimulation Intervention in 4- and 5-Year-Old Children With Developmental Language Disorder: Exploring Implementation in Clinical Practice
Authors: Bruinsma Gerda , Wijnen Frank , Gerrits Ellen
Published: April 2020

Purpose

Applying evidence-based grammar intervention can be challenging for speech and language therapists (SLTs). Language in Interaction Therapy (LIT) is a focused stimulation intervention for children with weak morphosyntactic skills, which was developed to support SLTs in incorporating results from effect studies in daily practice. The aims of this Clinical Focus are (a) to explain the principles and elements of LIT and stimulate use in daily SLT practice and (b) to describe the effects of LIT on morphosyntactic skills of 4- to 5-year-olds in special education, compared to usual care.

Method

With a description of LIT, we provide guidance to implement evidence-based intervention. Important elements are as follows: proper selection of therapy goals, language facilitating techniques, child-centered and clinician-directed elements, and the use of scripts. Our focus in the description is on the support and practical solutions LIT tries to provide to SLTs.

We also explored the implementation of LIT in special education, to improve morphosyntax in 4- and 5-year-old children. We provided SLTs with training and designed protocols for each therapy session. The effects of LIT were measured in a single-case A–B design, repeated in five children with developmental language disorders (ages 4;2–5;7 [years;months]).

Conclusion

We conclude that implementation of LIT is possible if LIT is enriched with support in goal selection, protocols to guide therapy sessions, and training and coaching. In the single-case study, four children showed more growth in mean length of utterance during and directly following the LIT intervention phase, compared to the baseline phase with usual care, and in two of them, this difference was significant. The grammatical complexity measure “TARSP-P” showed an overall significantly higher score at group level during LIT, but limited effects on an individual level.
Study on Tube Profile and Heat Transfer Characteristics Under Flying-Ash Erosion
Authors: Dong Yunshan , Si Fengqi , Yang Kun
Published: April 2020

Flying-ash erosion is the prime reason of the tube failure, involving the economy and safety of coal-fired power plants. To address this issue, computational fluid dynamics (CFD) is applied to this paper, which is coupled with the erosion profile calculation based on the dynamic mesh. The tube profile is analyzed under the flying-ash erosion, and the heat transfer process is further taken into account. The results indicate that as time goes on, the impact frequency and the incident angle decrease at the lower angle and increase at the higher angle. With time going on, the peak value becomes smaller at the saddle-shaped erosion rate curve, and the position of the peak value moves towards the higher angle. Meanwhile, both sides of the saddle-shaped curve expand towards the higher angle. That is, the erosion rate and the erosion loss become higher. The Nusselt number grows slightly and the trend grows faster as time goes on. The erosion profile leads to raising the temperature gradient at the angle of 0°, which induces the tube to rupture ultimately.
Application of Finite Element Power Flow and Visualization in Rolling Mill Vibration
Authors: Xiao Biao , Yan Xiaoqiang
Published: April 2020

The power flow harmonic responses of the upper roll system are obtained by combining the speed solution and stress solution, and compare with the traditional harmonic response, we find that the traditional vibration displacement, velocity and acceleration harmonic response spectrum can’t completely reflect the reality of the vibration energy. The power flow vectors of the mill can be obtained with a color vector program developed independently. Compared with the vibration displacement vectors, we found that the displacement vector distribution of the mill is quite different from that of the power flow vector with the frequency of 104Hz: the displacement vector amplitude gradually increases from the bottom to the top of the mill, and the displacement vector is transmitted from bottom to top vertically. The power flow vector amplitude of the working roll and the intermediate roll is larger than that of the other parts, and power flow vectors present complex transfer directions. Similarly, when the considering frequency is taken as other values, the distribution of vibration displacement vector and power flow vector are also variable.
Krisen – Wendepunkte im Leben?
Authors: Komalasari Schlenker Nila
Published: April 2020

Verlusterfahrungen, Angst oder Gewalterlebnisse sind nur einige von vielen möglichen Belastungen, denen Kinder und Jugendliche ausgesetzt sein können. Die Krise, die die Betroffenen dann durchleben, können sie nur dann bewältigen, wenn ihnen geeignete Strategien dafür zur Verfügung stehen.
Macroevolution and shifts in the feeding biology of the New World scarab beetle tribe Phanaeini (Coleoptera: Scarabaeidae: Scarabaeinae)
Authors: Gillett Conrad P D T , Toussaint Emmanuel F A
Published: April 2020

The New World scarab beetle tribe Phanaeini contains coprophagous, necrophagous, mycetophagous and suspected myrmecophilous species. We analyse the largest tribal molecular dataset assembled, incorporating, for the first time, the enigmatic monobasic genus Megatharsis, the thalassinus group of the subgenus Coprophanaeus (Metallophanaeus), and the subgenus Dendropaemon (Eurypodea) (formerly Tetramereia), unveiling their macroevolutionary and biogeographical history in light of Cenozoic abiotic changes and inferring shifts in feeding biology through time. We recover the contentious genus Gromphas outside an otherwise monophyletic Phanaeini. We infer Megatharsis in a clade containing the apparent myrmecophilous genus Dendropaemon, within the Coprophanaeus clade, and demonstrate that the subgenus Coprophanaeus (Metallophanaeus) is polyphyletic, whilst species groups within the subgenus Coprophanaeus (Coprophanaeus) are monophyletic. Our divergence time analyses and ancestral range estimation indicate an eastern South American origin for Phanaeini in the early Eocene, with subsequent colonization of Central America and the Nearctic during the Oligocene, long before a Panamanian land bridge. A shift to necrophagy in Coprophanaeus is possibly linked to increasing Neotropical small vertebrate diversity since the Eocene and, astonishingly, myrmecophily evolved from necrophagy 35 Mya. These drastic shifts in lifestyle are not concordant with variations in diversification rates and appear unlinked to Quaternary extinction of large mammals.
M2-branes and AdS/CFT: A review
Authors: Hosomichi Kazuo
Published: April 2020

We briefly review some of the important developments in the last decade in the theory of multiple M2-branes and $\text{AdS}_4/\text{CFT}_3$ correspondence. Taking the examples of the superconformal index, free energy on $S^3$, and entropy of charged black holes, we illustrate how the large-$N$ limit was studied and the correspondence was checked.
The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies
Authors: Busslinger Georg A. , Lissendorp Fianne , Franken Ingrid A. , van Hillegersberg Richard , Ruurda Jelle P. , Clevers Hans , de Maat Michiel F. G.
Published: April 2020

The incidence of adenocarcinoma at the gastrooesophageal junction increased over
the last years. Curative treatment for patients with upper gastrointestinal
(UGI) malignancies, such as oesophageal and gastric tumours, is challenging and
requires a multidisciplinary approach. Radical surgical resection with complete
lymphadenectomy is the cornerstone of UGI cancer treatment. Combined with
peri-operative treatment (i.e. by applying CROSS, EOX or FLOT regimen), the
survival is even better than with surgery alone. However, peri-operative
treatment is not effective in all patients, and the most effective strategy is a
topic of active debate, as is reflected by varying treatment guidelines between
countries. UGI cancers are (epi)genetically highly heterogeneous. It is thus not
likely that a uniform treatment will benefit all patients equally well. Over
recent years, patient-derived organoids (PDOs) gained more and more interest as
an
in vitro
prediction model that may assist as a diagnostic
tool in the future to select and eventually optimize the best peri-operative
treatments for each patient. PDOs can be derived from endoscopic tumour
biopsies, which maintain heterogeneity in culture. They can be rapidly
established and expanded in a relatively short time for
in
vitro
drug screening experiments. This review summarizes the
clinical and molecular aspects of oesophageal and gastric tumours, as well as
the current progress and remaining challenges in the use of PDOs for drug and
radiation screens.
CoViD–19: Meta-heuristic optimization based forecast method on time dependent bootstrapped data
Authors: Fenga Livio , Del Castello Carlo
Published: April 2020

A compounded method – exploiting the searching capabilities of an operation research algorithm and the power of bootstrap techniques – is presented. The resulting algorithm has been successfully tested to predict the turning point reached by the epidemic curve followed by the CoViD–19 virus in Italy. Futures lines of research, which include the generalization of the method to a broad set of distribution, will be finally given.
The relationship of COVID-19 severity with cardiovascular disease and its traditional risk factors: A systematic review and meta-analysis
Authors: Matsushita Kunihiro , Ding Ning , Kou Minghao , Hu Xiao , Chen Mengkun , Gao Yumin , Honda Yasuyuki , Dowdy David , Mok Yejin , Ishigami Junichi , Appel Lawrence J.
Published: April 2020

Background

Whether cardiovascular disease (CVD) and its traditional risk factors predict severe coronavirus disease 2019 (COVID-19) is uncertain, in part, because of potential confounding by age and sex.

Methods

We performed a systematic review of studies that explored pre-existing CVD and its traditional risk factors as risk factors of severe COVID-19 (defined as death, acute respiratory distress syndrome, mechanical ventilation, or intensive care unit admission). We searched PubMed and Embase for papers in English with original data (≥10 cases of severe COVID-19). Using random-effects models, we pooled relative risk (RR) estimates and conducted meta-regression analyses.

Results

Of the 661 publications identified in our search, 25 papers met our inclusion criteria, with 76,638 COVID-19 patients including 11,766 severe cases. Older age was consistently associated with severe COVID-19 in all eight eligible studies, with RR >∼5 in >60-65 vs. <50 years. Three studies showed no change in the RR of age after adjusting for covariate(s). In univariate analyses, factors robustly associated with severe COVID-19 were male sex (10 studies; pooled RR=1.73, [95%CI 1.50-2.01]), hypertension (8 studies; 2.87 [2.09-3.93]), diabetes (9 studies; 3.20 [2.26-4.53]), and CVD (10 studies; 4.97 [3.76-6.58]). RR for male sex was likely to be independent of age. For the other three factors, meta-regression analyses suggested confounding by age. Only four studies reported multivariable analysis, but most of them showed adjusted RR ∼2 for hypertension, diabetes, and CVD. No study explored renin-angiotensin system inhibitors as a risk factor for severe COVID-19.

Conclusions

Despite the potential for confounding, these results suggest that hypertension, diabetes, and CVD are independently associated with severe COVID-19 and, together with age and male sex, can be used to inform objective decisions on COVID-19 testing, clinical management, and workforce planning.
Non-food cropRosa canina Lleaf and twig extracts as a source of nutrients and bioactive compounds
Authors: Kubczak Małgorzata , Khassenova Ainur B. , Skalski Bartosz , Michlewska Sylwia , Wielanek Marzena , Aralbayeva Araylim N. , Nabiyeva Zhanar S. , Murzakhmetova Maira K. , Zamaraeva Maria , Skłodowska Maria , Bryszewska Maria , Ionov Maksim
Published: April 2020

It is important to search for new sources of bioactive, natural compounds because customers pay more attention to food quality. Fruits and berries from horticultural plants are known to be good sources of agents beneficial for human well-being and could serve as natural preservatives in the food industry. However, more recent research indicates that other plant organs can also be rich in nutrients. Our study focused on characterizing an unexplored source: leaf and twig extracts fromRosa canina. The chemical composition of these extracts was analyzed and theirin vitroactivity measured. HPLC analysis of the content of phenolics, vitamins and amino acids revealed that the leaf and twig extracts are rich in bioactive compounds with potent antioxidant properties. The greatest differences between bioactive phenolic compounds in leaf and twig extracts related mainly top-coumaric acid, myricetin, ellagic acid, cyanidin, procyanidin and quercetin, whereas salicylic acid levels were similar in both types of extract.

Interactions with human serum albumin were investigated and some conformational changes in protein structure were observed. Further analysis (lipid peroxidation, protein carbonylation, thiol group oxidation, DPPH inhibition and ROS inhibition) confirmed that both leaf and twig extracts exhibited antioxidant and antiradical scavenging activities. Cytotoxicity and hemotoxicity assays confirmed very low toxicity in the extracts over the range of concentrations tested. Our results indicate that both extracts could serve as non-toxic sources of bioactive compounds with antiradical properties.
ATM inhibition drives metabolic adaptation via induction of macropinocytosis
Authors: Chen Chi-Wei , Buj Raquel , Dahl Erika S. , Leon Kelly E. , Varner Erika L. , von Krusenstiern Eliana , Snyder Nathaniel W. , Aird Katherine M.
Published: April 2020

Macropinocytosis is a nonspecific endocytic process that enhances cancer cell survival under nutrient-poor conditions. Ataxia-Telangiectasia mutated (ATM) is a tumor suppressor that plays a role in cellular metabolic reprogramming. We report that suppression of ATM increases macropinocytosis in an AMPK-dependent manner to promote cancer cell survival in nutrient-poor conditions. Combined inhibition of ATM and macropinocytosis suppressed proliferation and induced cell death bothin vitroandin vivo. Metabolite analysis of the ascites and interstitial fluid from tumors indicated decreased branched chain amino acids (BCAAs) in the microenvironment of ATM-inhibited tumors. Supplementation of ATM inhibitor-treated cells with BCAAs abrogated AMPK phosphorylation and macropinocytosis and rescued the cell death that occurs due to combined inhibition of ATM and macropinocytosis. These data reveal a novel molecular basis of ATM-mediated tumor suppression whereby loss of ATM promotes pro-tumorigenic uptake of nutrients to promote cancer cell survival and reveal a metabolic vulnerability of ATM-inhibited cells.
ClonArch: Visualizing the Spatial Clonal Architecture of Tumors
Authors: Wu Jiaqi , El-Kebir Mohammed
Published: April 2020

Motivation

Cancer is caused by the accumulation of somatic mutations that lead to the formation of distinct populations of cells, called clones. The resulting clonal architecture is the main cause of relapse and resistance to treatment. With decreasing costs in DNA sequencing technology, rich cancer genomics datasets with many spatial sequencing samples are becoming increasingly available, enabling the inference of high-resolution tumor clones and prevalences across different spatial coordinates. While temporal and phylogenetic aspects of tumor evolution, such as clonal evolution over time and clonal response to treatment, are commonly visualized in various clonal evolution diagrams, visual analytics methods that reveal the spatial clonal architecture are missing.

Results

This paper introduces ClonArch, a web-based tool to interactively visualize the phylogenetic tree and spatial distribution of clones in a single tumor mass. ClonArch uses the marching squares algorithm to draw closed boundaries representing the presence of clones in a real or simulated tumor. ClonArch enables researchers to examine the spatial clonal architecture of a subset of relevant mutations at different prevalence thresholds and across multiple phylogenetic trees. In addition to simulated tumors with varying number of biopsies, we demonstrate the use of ClonArch on a hepatocellular carcinoma tumor with ~280 sequencing biopsies. ClonArch provides an automated way to interactively examine the spatial clonal architecture of a tumor, facilitating clinical and biological interpretations of the spatial aspects of intratumor heterogeneity.

Availability

https://github.com/elkebir-group/ClonArch
Formal Links between Feature Diversity and Phylogenetic Diversity
Authors: Wicke Kristina , Mooers Arne , Steel Mike
Published: April 2020

Abstract

The extent to which phylogenetic diversity (PD) captures feature diversity (FD) is a topical and controversial question in biodiversity conservation. In this short paper, we formalise this question and establish a precise mathematical condition for FD (based on discrete characters) to coincide with PD. In this way, we make explicit the two main reasons why the two diversity measures might disagree for given data; namely, the presence of certain patterns of feature evolution and loss, and using temporal branch lengths for PD in settings that may not be appropriate (e.g. due to rapid evolution of certain features over short periods of time). Our paper also explores the relationship between the ‘Fair Proportion’ index of PD and a simple index of FD (both of which correspond to Shapley values in cooperative game theory). In a second mathematical result, we show that the two indices can take identical values for any phylogenetic tree, provided the branch lengths in the tree are chosen appropriately.
Crystal structure, Hirshfeld surface analysis and interaction energy, DFT and antibacterial activity studies of ethyl 2-[(2Z)-2-(2-chlorobenzylidene)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl]acetate
Authors: Sebbar Ghizlane , Mohamed Ellouz , Hökelek Tuncer , Mague Joel T. , Sebbar Nada Kheira , Essassi El Mokhtar , Belkadi Bouchra
Published: April 2020

The title compound, C19H16ClNO3S, consists of chlorophenyl methylidene and dihydrobenzothiazine units linked to an acetate moiety, where the thiazine ring adopts a screw-boat conformation. In the crystal, two sets of weak C—HPh...ODbt (Ph = phenyl and Dbt = dihydrobenzothiazine) hydrogen bonds form layers of molecules parallel to the bc plane. The layers stack along the a-axis direction with intercalation of the ester chains. The crystal studied was a two component twin with a refined BASF of 0.34961 (5). The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions to the crystal packing are from H...H (37.5%), H...C/C...H (24.6%) and H...O/O...H (16.7%) interactions. Hydrogen-bonding and van der Waals interactions are the dominant interactions in the crystal packing. Computational chemistry indicates that in the crystal, C—HPh...ODbt hydrogen bond energies are 38.3 and 30.3 kJ mol−1. Density functional theory (DFT) optimized structures at the B3LYP/ 6–311 G(d,p) level are compared with the experimentally determined molecular structure in the solid state. The HOMO–LUMO behaviour was elucidated to determine the energy gap. Moreover, the antibacterial activity of the title compound has been evaluated against gram-positive and gram-negative bacteria.
Synthesis, crystal structure and Hirshfeld and thermal analysis of bis[benzyl 2-(heptan-4-ylidene)hydrazine-1-carboxylate-κ2
N
2,O]bis(thiocyanato)nickel(II)
Authors: Nithya Palanivelu , Govindarajan Subbiah , Simpson Jim
Published: April 2020

The title centrosymmetric NiII complex, [Ni(NCS)2(C15H22N2O2)2], crystallizes with one half molecule in the asymmetric unit of the monoclinic unit cell. The complex adopts an octahedral coordination geometry with two mutually trans benzyl-2-(heptan-4-ylidene)hydrazine-1-carboxylate ligands in the equatorial plane with the axial positions occupied by N-bound thiocyanato ligands. The overall conformation of the molecule is also affected by two, inversion-related, intramolecular C—H...O hydrogen bonds. The crystal structure features N—H...S, C—H...S and C—H...N hydrogen bonds together with C—H...π contacts that stack the complexes along the b-axis direction. The packing was further explored by Hirshfeld surface analysis. The thermal properties of the complex were also investigated by simultaneous TGA–DTA analyses.
An explorative optimization algorithm for sparse scheduling in-home energy management with smart grid
Authors: Gajula Viswanath , R. Rajathy
Published: April 2020

Purpose

Electricity utilization at electricity peak hour may differ from every single administration region, for example, mechanical region, business territory and residential zone. This paper introduces a demand-side load management (DSM) strategy, which is one of the utilization of smart grid (SG) that is fit for controlling loads inside the residential working so that the client fulfillment is augmented at least expense.

Design/methodology/approach

In this paper, a heuristic algorithms-based energy management controller is intended for a residential region in a SG. Here, Antlion Optimization technique is used for DSM techniques such as load shifting, peak clipping, and valley filling in the residential sectors for 24 h with the help of stochastic function to determine the detection of random distribution of the load.

Findings

This proposed algorithm offered the greatest fulfillment and least expense caused by the consumers when compared to the traditional cost by taking the individual consumer preferences for the loads and the ideal time scheduling for the load, which is obtained from the rebuilding trap.

Originality/value

Simulation results demonstrate that the comparison of the cost incurred by the users obtained by the DSM techniques is satisfiable.