bluuebunny/crossref_metadata_2025 huggingface dataset:
Eurobond Flotation by Russian Corporations and Finance Institutions
Authors: Tarasov A. A.
Published: December 2020

Eurobonds are one of the key instruments of international corporate financing. The article studies Eurobond market as a source of raising cash by Russian corporations and finance institutions. It provides structural parameters of Eurobonds and depicts types of securities available on debt market for Russian issuers (issues with one or several tranches, benchmark issues). The author analyzes results of Russian issuers’ flotation, including high activity on Eurobond market of exporting companies and successful flotation of ruble Eurobonds. The article studies transaction aspects of Eurobonds market: the role of principle participants of the deal (leading managers, global coordinators, book-runners) and key stages of the security flotation process (getting the credit rating, preparation of legal papers, syndication and marketing on market). It makes a comparative analysis of key instruments of raising finance by Russian borrowers on international markets of debt capital – Eurobonds and syndicated credits. These instruments both compete and supplement each other, which was proven by using the combination of Eurobonds and syndicated credits by leading borrowers. The article comes to the conclusion that combined use of these debt instruments for solving a wide range of finance problems is optimal for corporate capital structure and finance institutions.
Key Vectors of Regional Economic Policy: Expectations and Reality
Authors: Molchanova N. P.
Published: December 2020

The article investigates the structure of regional economic policy in historical context, from first years of market economy development in Russia to the current period of passing-over to digital economy. On the basis of dialectical method, system approach, practical analytical instruments, method of experts’ estimation reasons and consequences of evolution changes in regional economic policy were analyzed. Factors influencing the nature of social and economic processes on sub-national level were studied. The article shows today’s trends of space development characterized by the objective global process of raising the role of agglomeration in speeding-up economic growth, increasing labour productivity, incomes and standard of living of the population. Long-term prospects of development and functioning of rural territories were not evaluated adequately, though they play one of the key roles in growing geo-political influence of Russia in the world. Detail study of the theoretical base of regional economics allowed us to substantiate the issue of shifting the focus in managing the territorial development to macro-regional level and in this connection to renew instruments used for analytical purposes. By analyzing the home practice of state regulation a conclusion was drawn about the necessity to set up a specialized state structure for observing the process of strengthening the role of macro-regions and efficiency of shaping the adequate bodies of power to manage the space social and economic development.
The Impact of Finance and Business Activity of Special Economic Zone Residents on Social and Economic Development of the Region
Authors: Petrikova E. M. , Odnoral L. S.
Published: December 2020

On earlier stages of Russian economy establishment and development different institutional forms were built, which fostered social and economic development of territories, raising investment, attracting new technologies aimed at producing goods with high added value and cutting unemployment. The article discusses issues of special economic zone (SEZ), characterized as technical-introductory, and their impact on economic development of regions of their location. The efficiency of SEZ work was analyzed according to methodology approved by the Government of the Russian Federation. Statistics on key social and economic figures of regions proves the efficiency of SEZ work and their positive contribution to the territory development. A conclusion was drawn that SEZ in the near future can become key economic centers, which could integrate companies – SEZ residents by the cluster type and characterize the industry specialization of the region and at the same time could become a mighty stimulus for social and economic development of adjoining territories. Investment plans of companies – residents in the region and industry specialization of key companies and clusters on territories will start a new stage of building the efficient work aimed at complex SEZ development.
Identification of the Diagnostic Signature of Sepsis Based on Bioinformatic Analysis of Gene Expression and Machine Learning
Authors: Zhao Qian , Xu Ning , Guo Hui , Li Jianguo
Published: December 2020

Background:

Sepsis is a life-threatening disease caused by the dysregulated host
response to the infection and the major cause of death of patients in the intensive care unit (ICU).

Objective:

Early diagnosis of sepsis could significantly reduce in-hospital mortality. Though
generated from infection, the development of sepsis follows its own psychological process and
disciplines, alters with gender, health status and other factors. Hence, the analysis of mass data by
bioinformatics tools and machine learning is a promising method for exploring early diagnosis.

Methods:

We collected miRNA and mRNA expression data of sepsis blood samples from Gene
Expression Omnibus (GEO) and ArrayExpress databases, screened out differentially expressed
genes (DEGs) by R software, predicted miRNA targets on TargetScanHuman and miRTarBase
websites, conducted Gene Ontology (GO) term and KEGG pathway enrichment analysis based on
overlapping DEGs. The STRING database and Cytoscape were used to build protein-protein
interaction (PPI) network and predict hub genes. Then we constructed a Random Forest model by
using the hub genes to assess sample type.

Results:

Bioinformatic analysis of GEO dataset revealed 46 overlapping DEGs in sepsis. The PPI
network analysis identified five hub genes, SOCS3, KBTBD6, FBXL5, FEM1C and WSB1.
Random Forest model based on these five hub genes was used to assess GSE95233 and GSE95233
datasets, and the area under the curve (AUC) of ROC was 0.900 and 0.7988, respectively, which
confirmed the efficacy of this model.

Conclusion:

The integrated analysis of gene expression in sepsis and the effective Random Forest
model built in this study may provide promising diagnostic methods for sepsis.
TargetMM: Accurate Missense Mutation Prediction by Utilizing Local and Global Sequence Information with Classifier Ensemble
Authors: Ge Fang , Hu Jun , Zhu Yi-Heng , Arif Muhammad , Yu Dong-Jun
Published: December 2020

Aim and Objective:

Missense mutation (MM) may lead to various human diseases by
disabling proteins. Accurate prediction of MM is important and challenging for both protein
function annotation and drug design. Although several computational methods yielded acceptable
success rates, there is still room for further enhancing the prediction performance of MM.

Materials and Methods:

In the present study, we designed a new feature extracting method, which
considers the impact degree of residues in the microenvironment range to the mutation site.
Stringent cross-validation and independent test on benchmark datasets were performed to evaluate
the efficacy of the proposed feature extracting method. Furthermore, three heterogeneous
prediction models were trained and then ensembled for the final prediction. By combining the
feature representation method and classifier ensemble technique, we reported a novel MM
predictor called TargetMM for identifying the pathogenic mutations from the neutral ones.

Results:

Comparison outcomes based on statistical evaluation demonstrate that TargetMM
outperforms the prior advanced methods on the independent test data. The source codes and
benchmark datasets of TargetMM are freely available at https://github.com/sera616/TargetMM.git
for academic use.
A Pilot Study for Investigation of Plasma Amino Acid Profile in Neurofibromatosis Type 1 Patients
Authors: Oz Ozlem , Koyuncu Ismail , Gonel Ataman
Published: December 2020

Background:

Neurofibromatosis, also known as Von Recklinghausen disease, is a
systemic and progressive genetic disease that primarily affects the skin, eyes, nervous system, and
bones. The disease can occur in a variety of ways and can vary in individuals. Metabolomic-based
research using blood samples has enabled new diagnostic methods to be used in the diagnosis of
various diseases, especially cancer. Among the metabolites, profiling of plasma free amino acids
(PFAA) is a promising approach because PFAAs bind all organ systems and play an important role
in the metabolism.

Objective:

This study aimed to determine the characteristics of PFAA profiles in neurofibromatosis
patients and the possibility of using them for early detection and treatment of the disease.

Methods:

Patients with a diagnosis of Neurofibromatosis Type I confirmed by genetic
analysis and healthy individuals of the same age group without any disease were included in
the study. We analysed the nineteen plasma free amino acids (phenylalanine, proline,
threonine, arginine, asparagine, cystine, valine, glutamate, tyrosine, serine, glutamine,
glycine, tryptophane, leucine, lysine, methionine, isoleucine, aspartate and alanine) from
neurofibromatosis Type I patients and control group by liquid chromatography tandem mass
spectrometry (LC-MS/MS) in Metabolism Laboratory of Harran University Research and
Application Hospital. The results of the plasma free amino acid levels were divided into 3
groups as essential, semi-essential, and non-essential. The differences in amino acid levels
between groups were determined.

Results:

The levels of eight amino acids (methionine, arginine, cystine, glutamine, proline,
asparagine, serine, aspartate) were significantly altered in patients with neurofibromatosis type 1.
In essential amino acids, methionine levels were significantly higher in the patient group than
control group. While the levels of arginine and glutamine in semi-essential amino acids were
statistically significantly higher in the patient group, a significant decrease was observed in cystine
and proline levels compared to the control group's amino acid levels. In the non-essential amino
acids group, asparagine, serine and aspartate amino acid levels were significantly higher in the
patient group compared to the control group.

Conclusion:

The current research predicates that eight amino acids, namely methionine, arginine,
cystine, glutamine, proline, asparagine, serine, aspartate can be considered to be valuable
biomarkers for neurofibromatosis type I. This present study is the first to build models for
neurofibromatosis Type I screening using plasma free amino acids and the amino acid profile will
be able to guide the prediction of the complications that may occur during the course of the
disease.
Evolution of Writing Impairment in Spanish Patients with Alzheimer's Disease
Authors: González-Nosti María , Cuetos Fernando , Martínez Carmen
Published: December 2020

Background:

Although some studies suggest that writing difficulties may be one of the early
symptoms of Alzheimer's disease (AD), they have been scarcely studied compared to oral language. Particularly
noteworthy is the paucity of longitudinal studies that enable the observation of writing impairment
as cognitive decline progresses.

Objective:

The aim of this study was to examine the characteristics of writing in patients with AD and to
monitor the deterioration of their performance over a follow-up period.

Methods:

Sixty-four participants (half with AD and half healthy elderly) were compared in a word and
pseudo-word dictation task. Patients were evaluated every 6 months over a 2.5 year follow-up period.

Results:

The evolution of patient performance and error profile shows a typical pattern of deterioration,
with early damage to the lexical pathway, which later extends to the phonological pathway and eventually
affects peripheral processes.

Conclusion:

These results confirm the presence of writing difficulties from the early stages of AD, supporting
the value of this task for early diagnosis. Furthermore, it allows us to explain the contradictory
data obtained in previous investigations.
Therapeutic Options for the Treatment of 2019-Novel Coronavirus in
India: A Review
Authors: Dhanawat Meenakshi , Pahari Pratyay Kumar , Vyas Sonal , Aman Shahbaz , Singh Uday , Singh Kusheswar Prasad , Tiwari Rohit
Published: December 2020

Purpose:

As of from 30 Jan to 31 May, 2020, more than 182,143 confirmed cases reported in India along with
86,984 recovered cases and 5164 deceased cases of COVID-19. More than 53 countries are also affected with this pandemic
virus. However, the lack of specific drugs to prevent/treat this pandemic disease is a major problem at this current scenario.
In this regard, this systemic review was conducted to identify the therapeutic approaches and researches which are ongoing
in India against COVID-19.

Methods:

We had screened Google Scholar database with the keywords nCoV, corona virus in India, effect of SARS-CoV-2
in India, 2019-nCoV, treatment pattern in India for nCoV and therapy used to treat nCoV in India. In the final review we
had included a total of 49 articles.

Results:

As a result we had found that Indian Council of Medical Research and NIH have given a standard guideline of Hydroxychloroquine and other antiviral drugs for nCoV, and also there are various researches going on related to nCoV treatment like, chemicals from natural products, herbs and spices commonly used in India, combination therapy of lopinavir and
ritonavir, ultra-violet radiation therapy, molecular dynamic (MD) simulations of molecules for vaccine preparation, Convalescent plasma transfusion (CPT) therapy and many more.

Conclusions:

New drugs and therapy are in the premature stage for this hazardous pandemic. We need more time to gain the
detailed knowledge of the life cycle of the nCoV, which can speed up the drug/vaccine development process against nCoV.
COMPETITION OF JAVANESE AND INDONESIAN: A MIXED-METHODS APPROACH TO YOUNG MULTILINGUALS’ LANGUAGE CHOICE
Authors: Andriyanti Erna , Riazi Mehdi
Published: December 2020

Multilingualism differs from place to place, with different pressures and outcomes depending on each unique situation. In Indonesian context, an important factor is the status and over prestige afforded to the national language, posing a possible threat to local language vitality. This study reports the position of Javanese and Indonesian as parts of the language repertoire of young Yogyakartan multilinguals in three domains: home, school, and the street. A mixed-methods approach was used and the main data were collected through questionnaire and observations at ten participating high schools. The students’ survey was responded by 1,039 students. Their natural language use was recorded at school playground. Supporting data were collected from language teachers’ survey and interviews with school authorities. The findings show that Javanese and Indonesian still compete in the three domains but not in all sociolinguistic situations. The youths’ Javanese-Indonesian choice is mostly dependent on gender and parental level of education.Keywords: multilinguals, language domains, language choice, sociolinguistic study KOMPETISI BAHASA JAWA DAN BAHASA INDONESIA:PENDEKATAN MIXED-METHODS TERHADAPPILIHAN BAHASA ANAK MUDA MULTILINGUAL AbstrakMultilingualisme berbeda di satu tempat dari tempat lainnya, dengan penekanan dan hasil tergantung pada masing-masing situasi yang khas. Di dalam konteks Indonesia, faktor yang penting adalah status dan prestis yang disematkan untuk bahasa nasional, yang bisa mengancam vitalitas bahasa-bahasa daerah. Artikel ini mengkaji posisi bahasa Jawa dan bahasa Indonesia sebagai bagian dari repertoar bahasa anak muda multilingual di Yogyakarta dengan fokus pada tiga domain: rumah, sekolah, dan jalan. Pendekatan mixed-methods digunakan dan data utama dikumpulkan melalui kuesioner and observasi di sepuluh sekolah menengah. Survei terhadap siswa melibatkan 1.039 responden dan perekaman percakapan natural siswa dilakukan di saat jam istirahat. Data penunjang bersumber pada survei guru dan wawancara dengan pihak otoritas sekolah. Hasil penelitian menunjukkan bahwa penggunaan bahasa Jawa dan bahasa Indonesia masih berimbang di ketiga domain tetapi tidak pada semua situasi sosiolinguistik. Pilihan bahasa oleh responden sebagian besar berkorelasi positif terhadap gender dan tingkat pendidikan orang tua. Keywords: multilingual, domain bahasa, pilihan bahasa, kajian sosiolinguistik
Kemampuan berpikir kreatif matematis dalam penyelesaian soal open-ended jenis PISA berdasarkan level sekolah
Authors: Arista Evie Dwy Wahyu , Mahmudi Ali
Published: December 2020

Penelitian ini bertujuan untuk mendeskripsikan kemampuan berpikir kreatif matematis siswa dalam menyelesaikan soal open-ended jenis PISA ditinjau dari level sekolah. Jenis penelitian ini adalah penelitian survei dengan sampel penelitian terdiri dari 10 sekolah SMA di Kabupaten Lampung Timur dengan level sekolah tinggi, sedang, dan rendah berdasarkan akreditasi. Sampel penelitian ditentukan dengan stratified proporsional random sampling. Instrumen yang digunakan berupa tes kemampuan berpikir kreatif jenis soal open-ended PISA yang terdiri atas enam butir soal uraian dan pedoman wawancara. Instrumen tes yang digunakan telah dilakukan validasi isi oleh tiga orang ahli dengan rata-rata hasil validasi berkategori baik. Kami menganalisis data yang terkumpul secara deskriptif berdasarkan indikator dan kategori kemampuan berpikir kreatif matematis. Hasil penelitian menunjukkan bahwa siswa yang dijadikan sampel penelitian memiliki kemampuan berpikir kreatif matematis dengan indikator fluency, flexibility, originality, dan elaboration. Kemampuan berpikir kreatif matematis siswa dalam menyelesaikan soal open-ended jenis PISA mayoritas berada pada kategori cukup baik, baik di sekolah level tinggi, sedang, maupun rendah. Mathematical creative thinking skills in solving open-ended PISA-type problems based on school levelAbstractThis research aimed to describe the ability of students’ mathematical creative thinking in solving open-ended problems of PISA type based on the school level. This is survey research which involved 261 tenth graders from 10 schools with categories of the high, medium, and low school based on their accreditation in the district of Lampung Timur as the sample. We used stratified proportional random sampling to determine the sample. The instruments used in this research consisted of a creative thinking ability test with six constructed response items and interview guidelines. The instrument in the form of a test had been validated by three experts and it was proved to be valid in terms of its content with a good category. We analyzed the collected data descriptively based on the indicators and categories of creative thinking ability. The results show that students who became research samples have creative thinking ability with indicators of fluency, flexibility, originality, and elaboration. The majority of students’ mathematical creative thinking ability in solving open-ended problems of PISA type were in a fairly good category, both in high, medium, and low levels of school.
Psique e individuación: pérdida y recuperación del sentido de la vida
Authors: Hernández-Mella Rocío , Gómez-Mena Josefina , Santos-Batista Yolanda
Published: December 2020

Este ensayo reflexiona sobre la sensación de vacío que se aprecia a nivel personal y social y propone que se genera en la existencia de un ser humano que carece de un sentido profundo. El ensayo considera que cuando las urgencias de educar la voluntad han disminuido, emerge la profunda necesidad del alma de llevar una vida lejos de lo normal. Este vacío se produce subsumiendo la personalidad a la voluntad, separándole de la fuerza vital, primitiva y natural, a través de una cultura moderna que ha desprendido la fantasía de la existencia El análisis establece que en esta situación es necesario buscar ayuda para comprender el significado de la vida individual o la individuación, y una opción es la terapia analítica de orientación junguiana. Esta, utiliza los sueños para traer a la conciencia los símbolos, figuras y metáforas que habitan en las profundidades de la psique y corresponden a tiempos arcaicos de la humanidad lo cual devuelve el color emocional o la fuerza espiritual a la vida, como lo fue al principio de la vida de cada persona. Desde esta perspectiva, el ensayo argumenta cómo el ser humano encuentra su singularidad en una vida creativa que se expande cuando recupera esa unión primitiva con la naturaleza; reconociendo que, además, al restaurar el misterio en la existencia, la estima propia se reconstruye, así como una sensación de renovación produciendo un sentimiento de inmortalidad, puesto que el proceso de individuación no culmina en la autorrealización, sino que fluye desde la psique y permanece en ella.
The role of A. Makhmudov and Sh. Tagirov in the revival of book art traditions in the culture of the Middle Volga Region Tatars
Authors:   Kazan (Volga Region) Federal University, Vagapova Firdaus G. , Timofeeva Lyudmila S. ,   Kazan (Volga Region) Federal University
Published: December 2020

The article explores the period of reviving the art of calligraphy and handwritten book art in the Tatar culture, which falls on the end of the XIX century and is associated with the names of A. Makhmudov and Sh. Tagirov. The authors of the article presented the genesis and revealed the stages of calligraphy and hand-written book art formation in the culture of the Tatars. The article provides an art criticism analysis of the manuscript book art works included in the creative heritage of A. Makhmudov and Sh. Tagirov. A contrastive-comparative analysis led to a conclusion that the traditions of Iranian, Turkish and Dagestanian handwritten book art which were processed by Kazan calligraphers. That allowed them to develop local traditions of handwritten art. The study is based on the analysis of collections of manuscript monuments, including paperwork (khan labels) and books (of religious, scientific, literary and artistic content) from the collections of the Department of Manuscript and Rare Books of Kazan Federal University’s N.I. Lobachevsky Scientific Library, the Center for Written and Musical Heritage of G. Ibragimov Institute of the Language, Literature and Arts of the Republic of Tatarstan Academy of Sciences, the Department of Rare Books and Manuscripts of the Republic of Tatarstan National Library, the National Museum of the Republic of Tatarstan, the National Archives of the Republic of Tatarstan, the Graphics Department of the Republic of Tatarstan State Museum of Fine Arts. The article is based on a comprehensive study of the material; to conduct the analysis, analytical methods of research have been applied. The priority is given to the classical comparative-historical method which includes synchronous and diachronous analysis. In addition, general scientific art and cultural studies methods and approaches were implemented: the genetic one, for instance, allows making a diachronous section and tracing the process of book art formation.
Tatar women in the social life of Turkestan
Authors:   Namangan Institute of Engineering and Technology, Nasretdinova Dilfuza M.
Published: December 2020

The article presents information about Tatar women who played an important role in the social life of Turkestan in late 19th and early 20th centuries, for instance, how they founded charities and organised theatrical charity shows. The money received from the shows was donated to the funds rendering financial and moral support to injured soldiers, as well as the development of the medical sector in the country and the opportunity for local women to receive qualified medical care. The article highlightes other details which reveal the place of Tatar women in the social life of the region.
Tatar enlighteners and Gafur Gulyam’s creativity: cultural and literary cooperation
Authors:   Tashkent State University of Economics, Ernazarov Dilmurod Z. , Ilkhamdzhanov Lutfulla S. ,   Gafur Gulyam’s House-Museum of the Ministry of Culture of the Republic of Uzbekistan
Published: December 2020

The article discusses the influence of cultural and literary cooperation between Tatar, Bashkir and Uzbek enlighteners on the development of contemporary Uzbekistan and the country’s creative circles. The paper reveals the role of the outstanding Tatar poet, literary critic, publicist and translator G. Tukay in the formation of the Uzbek poet and publicist Gafur Gulyam’s worldview. The authors conducted a retrospective historical and literary analysis of the Uzbek and Tatar Soviet Socialistic Republic poets and writers.
Changes in PUFA and eicosanoid metabolism during/after apnea diving: a prospective single-center study
Authors:   Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany, Dolscheid-Pommerich Ramona C. , Weikert Juliane ,   Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Reinicke Madlen ,   Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Fimmers Rolf ,   Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany, toffel-Wagner Birgit ,   Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany, Erdfelter Felix ,   Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany, Ceglarek Uta ,   Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, Eichhorn Lars ,   Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany
Published: December 2020

Background: The popularity of apneic diving is continually growing. As apnea diving substantially burdens the cardiovascular system, special focus is warranted. Regarding inflammation processes and associated inflammatory-related diseases (e.g., cardiovascular diseases), eicosanoids play an important role. This study aims to investigate polyunsaturated fatty acids (PUFAs) and eicosanoids in voluntary apnea divers, and so to further improve understanding of pathophysiological processes focusing on proinflammatory effects of temporarily hypercapnic hypoxia. Methods: The concentration of PUFAs and eicosanoids were investigated in EDTA plasma in apnea divers (n=10) before and immediately after apnea, 0.5 hour and four hours later, applying liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: Mean age was 41±10 years, and divers performed a mean breath-hold time of 317±111 seconds. PUFAs, eicosanoids and related lipids could be classified in four different kinetical reaction groups following apnea. The first group (e.g., Ω-6 and Ω-3-PUFAs) showed an immediate concentration increase followed by a decrease below baseline four hours after apnea. The second group (e.g., thromboxane B2) showed a slower increase, with its maximum concentration 0.5 hour post-apnea followed by a decrease four hours post-apnea. Group 3 (9- and 13-hydroxyoctadecadienoic acid) is characterized by two concentration increase peaks directly after apnea and four hours afterward compared to baseline. Group 4 (e.g., prostaglandin D2) shows no clear response. Conclusions: Changes in the PUFA metabolism after even a single apnea revealed different kinetics of pro- and anti-inflammatory regulations and changes for oxidative stress levels. Due to the importance of these mediators, apnea diving should be evaluated carefully and be performed only with great caution against the background of cardiovascular diseases and inflammation processes.
A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents With Type 1 Diabetes
Authors: Palisaitis Emilie , El Fathi Anas , von Oettingen Julia E. , Haidar Ahmad , Legault Laurent
Published: December 2020

OBJECTIVE

We developed a meal detection algorithm for the artificial pancreas (AP+MDA) that detects unannounced meals and delivers automatic insulin boluses.

RESEARCH DESIGN AND METHODS

We conducted a randomized crossover trial in 11 adolescents aged 12–18 years with HbA1c ≥7.5% who missed one or more boluses in the past 6 months. We compared 1) continuous subcutaneous insulin infusion (CSII), 2) artificial pancreas (AP), and 3) AP+MDA. Participants underwent three 9-h interventions involving breakfast with a bolus and lunch without a bolus.

RESULTS

In AP+MDA, the meal detection time was 40.0 (interquartile range 40.0–57.5) min. Compared with CSII, AP+MDA decreased the 4-h postlunch incremental area under the curve (iAUC) from 24.1 ± 9.5 to 15.4 ± 8.0 h ⋅ mmol/L (P = 0.03). iAUC did not differ between AP+MDA and AP (19.6 ± 10.4 h ⋅ mmol/L, P = 0.21) or between AP and CSII (P = 0.33). The AP+MDA reduced time >10 mmol/L (58.0 ± 26.6%) compared with CSII (79.6 ± 27.5%, P = 0.02) and AP (74.2 ± 20.6%, P = 0.047).

CONCLUSIONS

The AP+MDA improved glucose control after an unannounced meal.
PELATIHAN PERSONAL BRANDING BAGI PERSIAPAN PENGEMBANGAN KARIR MAHASISWA TINGKAT AKHIR
Authors: Kadiyono Anissa Lestari
Published: December 2020

Masa pandemi covid-19 meningkatkan pengangguran dan mengancam tenaga kerja baru menjadi Sumber Daya Manusia dikarenakan kurangnya lapangan kerja yang berkualitas. Upaya yang dapat dilakukan oleh Perguruan Tinggi yang akan mencetak mahasiswa sebagai lulusan sarjana yang akan memasuki dunia kerja adalah dengan melakukan intervensi untuk meningkatkan kesiapan mahasiswa menghadapi dunia kerja. Intervensi yang dilakukan berupa program pelatihan dengan pemberian wawasan dan keterampilan yang dibutuhkan untuk meningkatkan kapasitas psikologis mahasiswa yang akan menjadi angkatan kerja baru, khususnya dalam hal Personal Branding. Pemberian program pelatihan dilakukan menggunakan konsep pengembangan karir yang memperhatikan tahap perkembangan karir mahasiswa yang berada pada tahap eksplorasi. Intervensi berupa pelatihan ini dilakukan pada 98 orang mahasiswa dan memberikan dampak positif pada pertambahan wawasan, keterampilan, dan kesiapan mahasiswa dalam memasuki dunia kerja. Hal ini dapat diterapkan pada perguruan tinggi lain untuk meningkatkan kesiapan mahasiswa dalam menghadapi dunia kerja. Pemberian program pelatihan dilakukan menggunakan konsep pengembangan karir yang memperhatikan tahap perkembangan karir mahasiswa yang berada pada tahap eksplorasi. Intervensi berupa pelatihan ini dilakukan pada 98 orang mahasiswa dan memberikan dampak positif pada pertambahan wawasan, keterampilan, dan kesiapan mahasiswa dalam memasuki dunia kerja. Hal ini dapat diterapkan pada perguruan tinggi lain untuk meningkatkan kesiapan mahasiswa dalam menghadapi dunia kerja.
A Cross-Sectional Overview: The Effect of the Covid-19 Pandemic on the Flow Rate of Orthopedic Truama Cases in Kuwait
Authors: Alsaifi Saleh , Boskandar Ahmad , Alkhaldi Saleh , Khaja Aliaa , Alhadhoud Meshal
Published: December 2020

Objective: The COVID-19 pandemic has led many countries to carry out a range of restrictions ranging from social distancing rules to full national lockdowns. The main aim of this study was to compare the flow rates of orthopaedic trauma injuries in Kuwait prior to the partial lockdown and during the curfew period. Method: Patient records for 641 isolated traumatic orthopedic injuries were collected pre and post the nationwide enforced partial curfew. The data was collected from the registries of 3 major orthopedic centers in the country. These hospitals cover a total of about 5 million people. Results: Hospitals of Kuwait received 356 patients in March-April of 2019 and 285 in the same months of 2020 during the curfew period. A slight decrease in the flow of orthopedic injuries was noted in the curfew period, but not a statistically significant one. Male to female ratio remained the same for both groups as well as the ratio for age groups. Femur fractures in the 2020 group were slightly higher and spine fractures were slightly lower than they were in 2019. Conclusion: A slight decrease in the number of patients who had orthopedic traumatic injuries was noted during the COVID-19 enforced partial curfew period. The decreased rate however, was not statistically significant.
Preparation of PhD in Social Work for teaching (the case of the Academy of Labour, Social Relations and Tourism)
Authors: Pozhydaieva Oksana
Published: December 2020

The modernization of legal regulations, adoption of standards for professional training of social workers, professional autonomy in the implementation of academic research actualize the necessity for seeking solutions to the problems of staffing the higher education institutions with scientific and pedagogical workers in the field of social work. This, in turn, requires analysis of experience in developing and implementing PhD programmes in social work that are intended to prepare doctoral students for teaching. The aim of the study was to analyze the experience of arranging the process of the PhD Programme in the specialty 231 "Social Work at the Academy of Labor, Social Relations and Tourism (Kyiv) with the focus on teaching skills development. The study objectives were to reveal the general provisions of the educational program; substantiate the content of the component of the educational program, which is focused on the formation of applicants for teaching competencies; describe the process and features of the formation of pedagogical competencies of future doctors of philosophy in the social work, namely professional knowledge, pedagogical skills of a University teacher. The research employed the method of analysis of normative documents, curriculum programs and assistant (pedagogical) practice, as well as the method of included observation was used. It was revealed that the educational program aims to train qualified scientists who are able to solve complex problems in the field of social work through research, based on a deep rethinking of existing and the creation of new holistic knowledge and / or innovative modification of professional practice. It is noted that an important educational component of the PhD program is the academic course "Innovative methods of teaching social work" and assistant (pedagogical) practice, the content of which is developed in accordance with international recommendations. The paper presents the purpose, program results, content, specified discipline and programs of assisting (pedagogical) practice. The peculiarities of implementation of these programs in the preparation of applicants are discussed.
Syllabus: structure, content and significance for the educational process in higher education institutions
Authors: Yatsura Mykhailo , Gamarnyk Anna , Tadeush Olga , Yemelyanova Darya
Published: December 2020

The article is devoted to topical issues related to the elaboration of modular educational programs, syllabi being their necessary components. The purpose of the article is to draw the attention of teachers and students in higher education institutions (HEI) to the problem of educational and methodological support of the educational process focusing on the content and meaning of a syllabus as one of the important educational and methodological instructional documents. The phenomenon “syllabus” is defined, its essence and objectives within the system of methodological support for teaching an academic discipline are revealed. A syllabus to the section of General Physics "Optics" intended for the specialty 104 (Physics and Astronomy) has been developed and introduced into the educational process, its most important elements have been singled out. Since, according to the authors’ viewpoints, the development of a separate syllabus for the laboratory workshop is inexpedient, one joint syllabus covering the theoretical part of the course "Optics", involving laboratory workshops within the study of this discipline, has been elaborated. The syllabus of optics consists of 16 sections as follows: title page; the contents of the syllabus; general characteristics of the discipline; prerequisites; post-requisites; discipline abstract; the purpose and objectives of the discipline; the results of the study; the organisation of training; course topics; academic calendar of discipline studies; knowledge assessment system; course policy ("Rules of the game"); policy of academic behaviour and ethics; recommended literature (references) for mastering the course. The syllabus is supplemented with a glossary of terms in the form of an appendix, which will undoubtedly be of service to the syllabus applicants. The results of the study revealed the content and importance of the syllabus for the educational process; its structure for the section of General Physics "Optics" was proposed which, in the authors’ opinion, fully meets the requirements of the credit-modular system of educational process. The authors hope that the designated syllabus will serve as an example for other sections of General Physics and some other disciplines. One of the authors has applied the structure of the developed syllabus with corresponding changes in its content for developing a syllabus of the discipline "Profession-targeted Foreign Language (English)".
Transformation of Oleksandr Dukhnovych’s pedagogical paradigm in the dimensions of modern domestic education
Authors: Kichuk Nadia
Published: December 2020

The problem of a creative use of the ideas that contain O. V. Dukhnovych’s pedagogical heritage in order to direct our search for constructive approaches to realisation of the concept “New Ukrainian School” has been raised. Special attention is paid to the parameters of the construct “substantial reform” which constitute the historical and pedagogical source bases. On the material of O. Dukhnovych’s elaborations, we focus on the attitudes related to textbook creation, organisation of schooling and pedagogisation of family education; this is the subject of the performed fundamental research. Since today it is not yet possible to effectively solve the new tasks set within the concept “New Ukrainian School”, this context of scientific understanding of O. Dukhnovych’s pedagogical paradigm has been actualised: creative adoption of the outstanding pedagogue-classicist’s ideas will contribute to the positive dynamics of the educational reform aimed at improving educational realities. The before mentioned issues constituted the purpose of the article and outlined the substantive content of its scientific objectives. A set of scientific and pedagogical methods, mainly of a theoretical level, was used to solve the outlined tasks: analysis, systematisation, generalisation, specification, modelling. It is noted that the scientific understanding of the pedagogical heritage of O. Dukhnovych creates an opportunity to understand the regularities of the gradual development of a corresponding pedagogical phenomenon better, for example of the ones the totality of which are concentrated in the problematic field of domestic education now – enhancement of the personal and professional mission of the pedagogue as “an agent of changes”, which (according to O. Dukhnovych) is “the greatest artist” from the perspective of “Pedagogy as an art”; enrichment of the national content of education through the imperative of teaching students in their native language; recognition of the basic importance of education as the general purpose of school and family as well as the meaning of education; full implementation of the conformity-to-nature principle to acquire “the joy of knowledge” by the child regardless of his / her educational needs. Reference is made to the context of O. Dukhnovych’s pedagogical paradigm with regard to solving the problems of small schools (in particular through the participation of village communities), bullying (in particular through stimulating public opinion). The historical and pedagogical provisions on the “substantiality” of any reform that correlates with “internal spiritual reform” are recognised as significant. Special attention is paid to the interpretation of the empirical data of the psychologists who characterise the involvement of modern pedagogues in innovations and actualise the historical and pedagogical heritage of O. Dukhnovych.
European practice of professional qualifications validation on the basis of non-formal education
Authors: Semigina Tetyana
Published: December 2020

The transformation of the labour market has led to paradigm shifts in education, contributing to the development of lifelong learning and non-formal education. Currently in Ukraine, there is no legal construct regulating the process of recognising the results of such education. The study aims to examine the European experience in validating the non-formal and informal education, which can be useful in formulating appropriate policies for the award of professional qualifications in Ukraine. The study is mainly based on a retrospective analysis of the European policy. Встановлено, що у визначенні процедур на загальноєвропейському рівні послуговуються такими документами, як: It is revealed that at the All-European level, these document are used to define the designated procedures: "European guidelines for the recognition of non-formal and informal education" (2009), Council of Europe Recommendations on the recognition of non-formal and informal education (2012), European Centre for the Development of Vocational Education (CEDEFOP) on the Recognition of Non-Formal and Informal Learning (2017), EU Council Recommendation on the European Qualifications Framework for Lifelong Learning (2017). These documents focus on the institutional field of validation of professional qualifications acquired through non-formal learning, involvement of representatives of various public sectors and implementation of coordination mechanisms. At the same time, diversified practice of confirmation and assignment of professional qualifications on the basis of non-formal learning has been developed in European countries. Professional associations and business structures, on the basis of which qualification centres (assessment centres) operate, play an important role in the processes of qualifications validation. The recognition of non-formal learning outcomes and validation of professional qualifications follow the same standards as the ones assigned for both formal education and the national qualifications framework.
Medical dilemmas – erythrocytosis
Authors: Lewandowski Krzysztof
Published: December 2020

Erythrocytosis is defined not only by an increase in the erythrocyte count, hemoglobin concentration, and hematocrit value, but also by the occurrence of specific symptoms, the intensity and frequency of which depend on the character of the initial genetic lesion. Ischemic episodes and thrombotic complications caused by increased blood viscosity are frequently the first clinical manifestation of the disease. This paper represents the current level of knowledge about the pathogenesis of erythrocytosis and the diagnostic algorithms used to precisely define the type of the disease.
The beneficial role of allogenic hematopoietic cell transplantation in blastic plasmacytoid dendritic cell neoplasm
Authors: Ulenberg Emilia , Lewandowski Krzysztof , Bieniaszewska Maria , Zaucha Jan Maciej
Published: December 2020

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare aggressive hematopoietic malignancy. The median survival is approximately 12 months, and for patients >65 years the survival rate is 7 months, when only chemotherapy is administered. Clinically, it is characterized by skin involvement and most often bone marrow lesions accompanied by lymphadenopathy and in some cases hepato- and/or splenomegaly. The diagnosis is based on histopathological examination of the skin or bone marrow lesions and tumor cell immunophenotyping. The etiopathogenesis of the disease is not fully understood. Therapeutic decisions are based only on the results of a few retrospective analyses and case reports. This article presents the important role of allogeneic hematopoietic cell transplantation in the treatment of BPDCN.
Myeloid-derived suppressor cells level and MUC1 expression in de novo acute myeloid leukemia
Authors: Nawar Sarah M. , Sultan Hala K. , Bedewy Ahmed M. , ElNaggar Amel A. , Mikhael Irene L.
Published: December 2020

Background

Acute myeloid leukemia (AML) is the most common acute leukemia occurring in adults. It is an aggressive myeloid neoplasm with maturation arrest of myelopoiesis, leading to an accumulation of myeloblasts in the bone marrow and peripheral blood.

Objective

To evaluate alterations in myeloid-derived suppressor cells level and MUC1 gene expression in patients with de novo acute myeloid leukemia concerning disease characteristics and response to induction chemotherapy.

Patients and methods

The study was performed on 50 AML patients and 50 healthy controls. Detection of myeloid-derived suppressor cells (MDSCs) in peripheral blood was performed by mononuclear separation and flow cytometry. MUC1 gene expression was performed by RNA extraction, reverse transcription, and real-time PCR at Hematology Department Medical Research Institute, Alexandria University.

Results

We have demonstrated that AML patients had both increased presence of MDSCs in peripheral blood as well as MUC1 overexpression in comparison to normal controls. MDSCs showed a significant correlation regarding response to induction chemotherapy on day 28. While MDSCs and not MUC1 are associated with inferior response to induction chemotherapy on day 28.

Conclusion

The current data suggested that AML patients exhibit an increased presence of MDSCs as well as MUC1 gene overexpression in comparison with normal controls. While MDSCs showed a significant correlation regarding response to induction chemotherapy on day 28, MDSCs and not MUC1 are associated with inferior response to induction chemotherapy on the same day.
Design of Artificial Lighting in Broiler Housing
Authors: Morvai Peter , Žitňák Miroslav , Lendelová Jana
Published: December 2020

The work aim is to propose lighting system designs that would satisfy the broiler welfare in terms of intensity; wavelength; switching interval; and energy savings, and would help farmers to reduce the unit costs. BuildingDesign software with Wils 7.0.342 module was used to design suitable lighting, calculate and visualize it. By optimizing the required parameters and energy performance of system, four final designs were prepared with the appropriate evaluation with respect to the acquisition price and return on investment. The original lighting system included a combination of 68 pcs. of tungsten and fluorescent lamps with consumption of 2.17 kWh and a minimum illumination intensity of 7.02 lx. Measurements were conducted at 212 points of the control grid. Artificial lighting is the only light source in an environment of eco-friendly controlled farm. Based on the research analyses, there were proposed four lighting system alternatives with various light intensity; wavelength; switch-on interval; and energy savings. In terms of light intensity, all four designs meet the animal welfare requirements. The most advantageous alternative in the long term is design no. 4 with consumption of 0.734 kWh per one cycle (with energy savings of 66.17% in contrast to the original lighting), in which the intermittent switching mode showed a power savings of 56% and lighting intensity regulation of 40% while maintaining a minimum lighting intensity of 20 lx (total savings for switching and regulation reached up to 73.7%). By utilizing modern approaches, appropriate light colour and lighting quality suitable for broiler breeding were achieved.