bluuebunny/crossref_metadata_2025 huggingface dataset:
Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety
Authors: Zečkanović Aida , Kavčič Marko , Prelog Tomaž , Šmid Alenka , Jazbec Janez
Published: March 2021

A major problem of oral iron supplementation efficacy in children is its tolerability and compliance. We aimed to determine the safety and efficacy of a novel food supplement >Your< Iron Syrup in the replenishment of iron stores and improvement of hematological parameters in iron-deficient children aged nine months to six years. We randomized 94 healthy children with iron deficiency in a ratio of 3:1 to either receive >Your< Iron Syrup or placebo. A 12-week supplementation with >Your< Iron Syrup resulted in a significant increase in ferritin and hemoglobin levels as compared to placebo (p = 0.04 and p = 0.02). Adverse events were reported with similar frequencies across both study arms. >Your< Iron Syrup represents an effective, well-tolerated, and safe option for the management of nutritional iron deficiency in children.
Anti-Inflammatory and Immune Modulatory Effects of Synbio-Glucan in an Atopic Dermatitis Mouse Model
Authors: Kim Yoon-Hwan , Kang Min Soo , Kim Tae Hyeong , Jeong Yunho , Ahn Jin-Ok , Choi Jung Hoon , Chung Jin-Young
Published: March 2021

Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan derived from oats with fermented probiotics (called Synbio-glucan) on an AD-induced mouse model. For the experiment, Nc/Nga mice were exposed to a house dust mite extract (HDM) to induce AD. The mice were placed in one of four groups: positive control group, Synbio-glucan topical treatment group, Synbio-glucan dietary treatment group, and Synbio-glucan topical + dietary treatment group. The experiment revealed no significant difference in the serum IgE concentration among the groups. Serum cytokine antibody arrays showed that genes related to the immune response were enriched. A significant difference in the skin lesion scores was observed between the groups. Compared to the control group tissue, skin lesions were alleviated in the Synbio-glucan topical treatment group and Synbio-glucan dietary treatment group. Interestingly, almost normal structures were observed within the skin lesions in the Synbio-glucan topical + dietary treatment group. Overall, the β-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis.
The Neural Network of Neuropeptide S (NPS): Implications in Food Intake and Gastrointestinal Functions
Authors: Botticelli Luca , Micioni Di Bonaventura Emanuela , Ubaldi Massimo , Ciccocioppo Roberto , Cifani Carlo , Micioni Di Bonaventura Maria
Published: March 2021

The Neuropeptide S (NPS), a 20 amino acids peptide, is recognized as the endogenous ligand of a previously orphan G protein-coupled receptor, now termed NPS receptor (NPSR). The limited distribution of the NPS-expressing neurons in few regions of the brainstem is in contrast with the extensive expression of NPSR in the rodent central nervous system, suggesting the involvement of this receptor in several brain functions. In particular, NPS promotes locomotor activity, behavioral arousal, wakefulness, and unexpectedly, at the same time, it exerts anxiolytic-like properties. Intriguingly, the NPS system is implicated in the rewarding properties of drugs of abuse and in the regulation of food intake. Here, we focus on the anorexigenic effect of NPS, centrally injected in different brain areas, in both sated and fasted animals, fed with standard or palatable food, and, in addition, on its influence in the gastrointestinal tract. Further investigations, regarding the role of the NPS/NPSR system and its potential interaction with other neurotransmitters could be useful to understand the mechanisms underlying its action and to develop novel pharmacological tools for the treatment of aberrant feeding patterns and obesity.
Filociclovir Is an Active Antiviral Agent against Ocular Adenovirus Isolates In Vitro and in the Ad5/NZW Rabbit Ocular Model
Authors: Romanowski Eric G. , Hussein Islam T. M. , Cardinale Steven C. , Butler Michelle M. , Morin Lucas R. , Bowlin Terry L. , Yates Kathleen A. , Shanks Robert M. Q. , Kowalski Regis P.
Published: March 2021

Presently, there is no FDA- or EMA-approved antiviral for the treatment of human adenovirus (HAdV) ocular infections. This study determined the antiviral activity of filociclovir (FCV) against ocular HAdV isolates in vitro and in the Ad5/NZW rabbit ocular model. The 50% effective concentrations (EC50) of FCV and cidofovir (CDV) were determined for several ocular HAdV types using standard plaque reduction assays. Rabbits were topically inoculated in both eyes with HAdV5. On day 1, the rabbits were divided into four topical treatment groups: (1) 0.5% FCV 4x/day × 10 d; (2) 0.1% FCV 4x/day × 10 d; (3) 0.5% CDV 2x/day × 7 d; (4) vehicle 4x/day × 10 d. Eyes were cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14. The resulting viral eye titers were determined using standard plaque assays. The mean in vitro EC50 for FCV against tested HAdV types ranged from 0.50 to 4.68 µM, whereas those treated with CDV ranged from 0.49 to 30.3 µM. In vivo, compared to vehicle, 0.5% FCV, 0.1% FCV, and 0.5% CDV produced lower eye titers, fewer numbers of positive eye cultures, and shorter durations of eye infection. FCV demonstrated anti-adenovirus activity in vitro and in vivo.
Non-Viral Gene Delivery Systems
Authors: Faneca Henrique
Published: March 2021

The advances in the field of gene therapy have significantly improved the possibility for nucleic acids as highly promising agents for the treatment of both inherited and acquired human diseases [...]
Medicine Shortages in Serbia: Pharmacists’ Standpoint and Potential Solutions for a Non-EU Country
Authors: Jovanović Lješković Nataša , Jovanović Galović Aleksandra , Stojkov Svetlana , Jojić Nikola , Gigov Slobodan
Published: March 2021

Medicine shortages in Serbia have evidently been present for several decades, but literature data are scarce. The aim of our study was to get an insight on the present situation in Serbia, review the EU actions when managing shortages, and discern a set of potential measures. A short survey was conducted among 500 pharmacists in public pharmacies, in 23 cities in Serbia. The survey questions addressed frequency of drug shortages, professional actions in the event of shortages, main consequences to patients and pharmacies, putative causes, and pivotal measures for the prevention/mitigation of drug shortages under current conditions. Moreover, a Panel of Experts was organized, whose suggestions and opinions were used to analyze the present situation and to form a set of potential solutions and effective measures to mitigate shortages of medicines. In-depth analysis of current Serbian legislation was conducted, with emphasis on specific steps to be made within the actual legal framework. Examples of good practice in the EU, applicable to a country such as Serbia, were examined. Our research showed that although Serbia is, in some aspects, behind EU countries regarding the approaches to overcome medicine shortages, progress can be made within short period of time, by specific well-targeted actions. Both patients and pharmacists would benefit from it.
The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review
Authors: Szulc-Musioł Beata , Sarecka-Hujar Beata
Published: March 2021

In recent years, polyphenols have been extensively studied due to their antioxidant, anticancer, and anti-inflammatory properties. It has been shown that anthocyanins, flavonols, and flavan-3-ols play an important role in the prevention of bacterial infections, as well as vascular or skin diseases. Particularly, resveratrol, as a multi-potent agent, may prevent or mitigate the effects of oxidative stress. As the largest organ of the human body, skin is an extremely desirable target for the possible delivery of active substances. The transdermal route of administration of active compounds shows many advantages, including avoidance of gastrointestinal irritation and the first-pass effect. Moreover, it is non-invasive and can be self-administered. However, this delivery is limited, mainly due to the need to overpassing the stratum corneum, the possible decomposition of the substances in contact with the skin surface or in the deeper layers thereof. In addition, using resveratrol for topical and transdermal delivery faces the problems of its low solubility and poor stability. To overcome this, novel systems of delivery are being developed for the effective transport of resveratrol across the skin. Carriers in the micro and nano size were demonstrated to be more efficient for safe and faster topical and transdermal delivery of active substances. The present review aimed to discuss the role of resveratrol in the treatment of skin abnormalities with a special emphasis on technologies enhancing transdermal delivery of resveratrol.
Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin
Authors: Toropainen Elisa , Fraser-Miller Sara J. , Novakovic Dunja , Del Amo Eva M. , Vellonen Kati-Sisko , Ruponen Marika , Viitala Tapani , Korhonen Ossi , Auriola Seppo , Hellinen Laura , Reinisalo Mika , Tengvall Unni , Choi Stephanie , Absar Mohammad , Strachan Clare , Urtti Arto
Published: March 2021

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experimental suspensions with two particle sizes and three viscosities, one commercial suspension) in physical and biological tests. The median particle size (d50) categories of the experimental suspensions were 0.37–1.33 and 3.12–3.50 µm and their viscosity levels were 1.3, 7.0, and 15 mPa·s. Smaller particle size facilitated ocular absorption of indomethacin to the aqueous humor of albino rabbits. In aqueous humor the AUC values of indomethacin suspensions with different particle sizes, but equal viscosity, differed over a 1.5 to 2.3-fold range. Higher viscosity increased ocular absorption 3.4–4.3-fold for the suspensions with similar particle sizes. Overall, the bioavailability range for the suspensions was about 8-fold. Instillation of larger particles resulted in higher tear fluid AUC values of total indomethacin (suspended and dissolved) as compared to application of smaller particles. Despite these tear fluid AUC values of total indomethacin, instillation of the larger particles resulted in smaller AUC levels of indomethacin in the aqueous humor. This suggests that the small particles yielded higher concentrations of dissolved indomethacin in the tear fluid, thereby leading to improved ocular bioavailability. This new conclusion was supported by ocular pharmacokinetic modeling. Both particle size and viscosity have a significant impact on drug concentrations in the tear fluid and ocular drug bioavailability from topical suspensions. Viscosity and particle size are the key players in the complex interplay of drug retention and dissolution in the tear fluid, thereby defining ocular drug absorption and bioequivalence of ocular suspensions.
Characterization of an Experimental Two-Step Self-Etch Adhesive’s Bonding Performance and Resin-Dentin Interfacial Properties
Authors: Chowdhury Abu Faem Mohammad Almas , Alam Arefin , Yamauti Monica , Álvarez Lloret Pedro , Saikaew Pipop , Carvalho Ricardo Marins , Sano Hidehiko
Published: March 2021

This study evaluated an experimental two-step self-etch adhesive (BZF-29, BZF) by comparing it with a reference two-step self-etch adhesive (Clearfil Megabond 2, MB) and a universal adhesive (G-Premio Bond, GP) for microtensile bond strength (μTBS) and resin-dentin interfacial characteristics. Twenty-four human third molars were used for the μTBS test. Bonded peripheral dentin slices were separated to observe the resin-dentin interface and measure the adhesive layer thickness with SEM. μTBS data of the central beams were obtained after 24 h and 6 months of water storage. Fracture modes were determined using a stereomicroscope and SEM. Nine additional third molars were used to determine the elastic modulus (E) employing an ultra microhardness tester. Water storage did not affect μTBS of the tested adhesives (p > 0.05). μTBS of BZF and MB were similar but significantly higher than GP (p < 0.05). BZF achieved the highest adhesive layer thickness, while GP the lowest. E of BZF and MB were comparable but significantly lower than GP (p < 0.05). Except for GP, the predominant fracture mode was nonadhesive. The superior bonding performance of BZF and MB could be attributed to their better mechanical property and increased adhesive thickness imparting better stress relief at the interface.
Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing
Authors: Masri Syafira , Fauzi Mh Busra
Published: March 2021

Skin tissue engineering aimed to replace chronic tissue injury commonly occurred due to severe burn and chronic wound in diabetic ulcer patients. The normal skin is unable to be regenerated until the seriously injured tissue is disrupted and losing its function. 3D-bioprinting has been one of the effective methods for scaffold fabrication and is proven to replace the conventional method, which reported several drawbacks. In light of this, researchers have developed a new fabrication approach via 3D-bioprinting by combining biomaterials (bioinks) with cells and biomolecules followed by a suitable crosslinking approach. This advanced technology has been subcategorised into three different printing techniques including inject-based, laser-based, and extrusion-based printing. However, the printable quality of the currently available bioinks demonstrated shortcomings in the physicochemical and mechanical properties. This review aims to identify the limitations raised by using natural-based bioinks and the optimum temperature for various applied printing techniques. It is essential to ensure maintaining the acceptable printed scaffold property such as the optimum pore sizes and porosity that allow cell migration activity. In addition, the properties required for an ideal bioinks design for better scaffold printability were also summarised.
Use of Artificial Neural Networks to Optimize Stacking Sequence in UHMWPE Protections
Authors: Peinado Jairo , Jiao-Wang Liu , Olmedo Álvaro , Santiuste Carlos
Published: March 2021

The aim of the present work is to provide a methodology to evaluate the influence of stacking sequence on the ballistic performance of ultra-high molecular weight polyethylene (UHMWPE) protections. The proposed methodology is based on the combination of experimental tests, numerical modelling, and Artificial Neural Networks (ANN). High-velocity impact experimental tests were conducted to validate the numerical model. The validated Finite Element Method (FEM) model was used to provide data to train and to validate the ANN. Finally, the ANN was used to find the best stacking sequence combining layers of three UHMWPE materials with different qualities. The results showed that the three UHMWPE materials can be properly combined to provide a solution with a better ballistic performance than using only the material with highest quality. These results imply that costs can be reduced increasing the ballistic limit of the UHMWPE protections. When the weight ratios of the three materials remain constant, the optimal results occur when the highest-performance material is placed in the back face. Furthermore, ANN simulation showed that the optimal results occur when the weight ratio of the highest-performance material is 79.2%.
Novel Hybrid Polymer Composites with Graphene and MXene Nano-Reinforcements: Computational Analysis
Authors: Kilikevičius Sigitas , Kvietkaitė Saulė , Mishnaevsky Leon , Omastová Mária , Aniskevich Andrey , Zeleniakienė Daiva
Published: March 2021

This paper presents a computational analysis on the mechanical and damage behavior of novel hybrid polymer composites with graphene and MXene nano-reinforcements targeted for flexible electronics and advanced high-strength structural applications with additional functions, such as real-time monitoring of structural integrity. Geometrical models of three-dimensional representative volume elements of various configurations were generated, and a computational model based on the micromechanical finite element method was developed and solved using an explicit dynamic solver. The influence of the geometrical orientation, aspect ratio, and volume fractions of the inclusions, as well as the interface properties between the nano-reinforcements and the matrix on the mechanical behavior, was determined. The results of the presented research give initial insights about the mechanical and damage behavior of the proposed composites and provide insight for future design iterations of similar multifunctional materials.
Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery
Authors: Chou Tzung-Han , Nugroho Daniel Setiyo , Chang Jia-Yaw , Cheng Yu-Shen , Liang Chia-Hua , Deng Ming-Jay
Published: March 2021

Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed nanoemulsions (NEs) using an anti-oxidative polymeric amphiphile, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), hydrogenated soy lecithin (HL), black soldier fly larvae (BSFL) oil, and avocado (AV) oil through pre-homogenization and ultrasonication method. Addition of TPGS (weight ratios 100 and 50% as compared to HL) into NEs effectively reduced particle size and phase transition region area of NEs with pure HL. Incorporation of Apig into NEs made particle size increase and provided a disorder effect on intraparticle molecular packing. Nevertheless, the encapsulation efficiency of NEs for Apig approached to about 99%. The chemical stability of Apig was significantly improved and its antioxidant ability was elevated by incorporation with BSFL oil and AV oil NEs, especially for NEs with single TPGS. NEs with single TPGS also exhibited the best Apig skin deposition. For future application of topical Apig delivery, NEs-gel was formed by the addition of hyaluronic acid (HA) into NEs. Their rheological characteristics were dominated by the surfactant ratios of HL to TPGS.
Finite Element Method-Based Simulation Creep Behavior of Viscoelastic Carbon-Fiber Composite
Authors: Katouzian Mostafa , Vlase Sorin , Scutaru Maria Luminita
Published: March 2021

Usually, a polymer composite with a viscoelastic response matrix has a creep behavior. To predict this phenomenon, a good knowledge of the properties and mechanical constants of the material becomes important. Schapery’s equation represents a basic relation to study the nonlinear viscoelastic creep behavior of composite reinforced with carbon fiber (matrix made by polyethrtethrtketone (PEEK) and epoxy resin). The finite element method (FEM) is a classic, well known and powerful tool to determine the overall engineering constants. The method is applied to a fiber one-directional composite for two different applications: carbon fibers T800 reinforcing an epoxy matrix Fibredux 6376C and carbon fibers of the type IM6 reinforcing a thermoplastic material APC2. More cases have been considered. The experimental results provide a validation of the proposed method and a good agreement between theoretical and experimental results.
Finite Element Modelling and Experimental Validation of Scratches on Textured Polymer Surfaces
Authors: Gao Weimin , Wang Lijing , Coffey Jolanta K. , Wu Hongren , Daver Fugen
Published: March 2021

Surface texturing is a common modification method for altering the surface properties of a material. Predicting the response of a textured surface to scratching is significant in surface texturing and material design. In this study, scratches on a thermoplastic material with textured surface are simulated and experimentally tested. The effect of texture on scratch resistance, surface visual appearance, surface deformation and material damage are investigated. Bruise spot scratches on textured surfaces are found at low scratch forces (<3 N) and their size at different scratch forces is approximately the same. There is a critical point between the bruise spot damage and the texture pattern damage caused by continuous scratching. Scratch resistance coefficients and an indentation depth-force pattern are revealed for two textured surfaces. A texture named “Texture CB” exhibits high effectiveness in enhancing scratch visibility resistance and can increase the scratch resistance by more than 40% at low scratch forces. The simulation method and the analysis of the power spectral density of the textured surface enable an accurate prediction of scratches.
Detailed Process Analysis of Biobased Polybutylene Succinate Microfibers Produced by Laboratory-Scale Melt Electrospinning
Authors: Ostheller Maike-Elisa , Balakrishnan Naveen Kumar , Groten Robert , Seide Gunnar
Published: March 2021

Melt electrospinning is widely used to manufacture fibers with diameters in the low micrometer range. Such fibers are suitable for many biomedical applications, including sutures, stents and tissue engineering. We investigated the preparation of polybutylene succinate microfibers using a single-nozzle laboratory-scale device, while varying the electric field strength, process throughput, nozzle-to-collector distance and the temperature of the polymer melt. The formation of a Taylor cone followed by continuous fiber deposition was observed for all process parameters, but whipping behavior was enhanced when the electric field strength was increased from 50 to 60 kV. The narrowest fibers (30.05 µm) were produced using the following parameters: electric field strength 60 kV, melt temperature 235 °C, throughput 0.1 mL/min and nozzle-to-collector distance 10 cm. Statistical analysis confirmed that the electric field strength was the most important parameter controlling the average fiber diameter. We therefore report the first production of melt-electrospun polybutylene succinate fibers in the low micrometer range using a laboratory-scale device. This offers an economical and environmentally sustainable alternative to conventional solution electrospinning for the preparation of safe fibers in the micrometer range suitable for biomedical applications.
The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview
Authors: Chiodi Elisa , Marn Allison M. , Geib Matthew T. , Ünlü M. Selim
Published: March 2021

The importance of microarrays in diagnostics and medicine has drastically increased in the last few years. Nevertheless, the efficiency of a microarray-based assay intrinsically depends on the density and functionality of the biorecognition elements immobilized onto each sensor spot. Recently, researchers have put effort into developing new functionalization strategies and technologies which provide efficient immobilization and stability of any sort of molecule. Here, we present an overview of the most widely used methods of surface functionalization of microarray substrates, as well as the most recent advances in the field, and compare their performance in terms of optimal immobilization of the bioreceptor molecules. We focus on label-free microarrays and, in particular, we aim to describe the impact of surface chemistry on two types of microarray-based sensors: microarrays for single particle imaging and for label-free measurements of binding kinetics. Both protein and DNA microarrays are taken into consideration, and the effect of different polymeric coatings on the molecules’ functionalities is critically analyzed.
Paper Ageing: The Effect of Paper Chemical Composition on Hydrolysis and Oxidation
Authors: Małachowska Edyta , Pawcenis Dominika , Dańczak Jacek , Paczkowska Joanna , Przybysz Kamila
Published: March 2021

The degradation of cellulose is an important factor influencing its mechanical, optical, physical, and chemical properties and, hence, the lifetime of paper in libraries and archival collections. Regardless of the complexity of the paper material, the main chemical pathways for its degradation are hydrolysis and oxidation. This study presents an overview of the analytical techniques employed in the evaluation of the hydrolysis and oxidation processes; these techniques include size-exclusion chromatography, Fourier-transform infrared and ultraviolet–visible spectroscopy, and X-ray diffraction. This paper aims to determine the extent to which these instrumental methods are useful for studying the aforementioned processes and for which lignin contents. It also highlights how atmospheric humidity could affect the cellulose structure in paper containing lignin. It was found that humidity causes significant changes in the cellulose chain lengths and that a high lignin content in paper could suppress some cellulose degradation pathways. This knowledge can be applied to developing strategies and selective chemical treatments preventing the consequences of paper ageing.
Influence of the Polymer Microstructure over the Phase Separation of Thermo-Responsive Nanoparticles
Authors: Manfredini Nicolò , Tomasoni Marco , Sponchioni Mattia , Moscatelli Davide
Published: March 2021

Thermo-responsive nanoparticles (NPs), i.e., colloids with a sharp and often reversible phase separation in response to thermal stimuli, are coming to the forefront due to their dynamic behavior, useful in applications ranging from biomedicine to advanced separations and smart optics. What is guiding the macroscopic behavior of these systems above their critical temperature is mainly the microstructure of the polymer chains of which these NPs are comprised. Therefore, a comprehensive understanding of the influence of the polymer properties over the thermal response is highly required to reproducibly target a specific behavior. In this study, we synthesized thermo-responsive NPs with different size, polymeric microstructure and hydrophilic-lipophilic balance (HLB) and investigated the role of these properties over their phase separation. We first synthesized four different thermo-responsive oligomers via Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization of poly(ethylene glycol)methyl ether methacrylate. Then, exploiting the RAFT living character, we chain-extended these oligomers with butyl methacrylate obtaining a library of NPs. Finally, we investigated the NP thermo-responsive behavior, their physical state above the cloud point (Tcp) as well as their reversibility once the stimulus is removed. We concluded that the solid content plays a minor role compared to the relative length of the two blocks forming the polymer chains. In particular, the longer the stabilizer, the more favored the formation of a gel. At the same time, the reversibility is mainly achieved at high HLB, independently from the absolute lengths of the block copolymers.
Facile Synthesis of Polyethylene Glycol@Tannin-Amine Microsphere towards Cr(VI) Removal
Authors: Yuan Chengbing , Zhang Yan , Yao Jinshui , Liu Qinze , Kong Fan-Gong
Published: March 2021

Herein, a synthetic strategy for a rough microsphere Cr(VI)-adsorbent via the reaction of tannic acid (TA) and 1,6-hexanediamine (HA) and using polyethylene glycol (PEG) as surface modifier was presented. This adsorbent was characterized by a Fourier Transform Infrared spectrometer (FTIR), thermogravimetic analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. Certain factors, including contact time, PEG@poly(tannin-1,6-hexanediamine) (PEG@PTHA) dosage, initial concentration, and experimental temperature affecting the Cr(VI) adsorption performance of adsorbent were explored. PEG@PTHA can adsorb Cr and the Cr(VI) was reduced up to Cr(III) due to the existence of phenolic hydroxyl groups. Its adsorption capacity can reach up to 300 mg/g within 10 min and approximately 100% removal percentage below the initial concentration of 100 mg/L. Its behavior matched well with the Langmuir isotherm model and pseudo-second-order kinetic model. A PEG@PTHA adsorbent with maximum adsorption capacity (450 mg/g) has great prospects in Cr(VI)-sewage treatment.
Development of Conductive Gelatine-Methacrylate Inks for Two-Photon Polymerisation
Authors: Sanjuan-Alberte Paola , Vaithilingam Jayasheelan , Moore Jonathan C. , Wildman Ricky D. , Tuck Christopher J. , Alexander Morgan R. , Hague Richard J. M. , Rawson Frankie J.
Published: March 2021

Conductive hydrogel-based materials are attracting considerable interest for bioelectronic applications due to their ability to act as more compatible soft interfaces between biological and electrical systems. Despite significant advances that are being achieved in the manufacture of hydrogels, precise control over the topographies and architectures remains challenging. In this work, we present for the first time a strategy to manufacture structures with resolutions in the micro-/nanoscale based on hydrogels with enhanced electrical properties. Gelatine methacrylate (GelMa)-based inks were formulated for two-photon polymerisation (2PP). The electrical properties of this material were improved, compared to pristine GelMa, by dispersion of multi-walled carbon nanotubes (MWCNTs) acting as conductive nanofillers, which was confirmed by electrochemical impedance spectroscopy and cyclic voltammetry. This material was also confirmed to support human induced pluripotent stem cell-derived cardiomyocyte (hPSC-CMs) viability and growth. Ultra-thin film structures of 10 µm thickness and scaffolds were manufactured by 2PP, demonstrating the potential of this method in areas spanning tissue engineering and bioelectronics. Though further developments in the instrumentation are required to manufacture more complex structures, this work presents an innovative approach to the manufacture of conductive hydrogels in extremely low resolution.
Effect of the Process Parameters on the Adhesive Strength of Dissimilar Polymers Obtained by Multicomponent Injection Molding
Authors: Pisanu Luciano , Santiago Leonardo Costa , Barbosa Josiane Dantas Viana , Beal Valter Estevão , Nascimento Marcio Luis Ferreira
Published: March 2021

The growing demand in the consumer market for products with sustainable technologies has motivated new applications using overmolded natural fiber composites. Therefore, studies have been conducted mainly to understand the adhesive properties of overmolded parts. In the present study, a polypropylene (PP) composite with 30% coconut fibers without additives was developed with the aid of a corotating twin screw extruder. Subsequently, a multicomponent injection mold was developed based on the geometry of the ISO 527 type I specimen, in which samples overmolded with PP and PP–coconut-fiber composite, with the overlap in the central area, were obtained to evaluate the adhesive strength of dissimilar materials. The objective of this study was to evaluate the bond between PP and PP–coconut-fiber composite under different processing conditions using an adhesive strength testing device to perform a pure shear analysis. The experimental conditions followed a statistical design considering four factors in two levels and a significance level of 5%. The results indicated that adhesive strength increased significantly as the overlap area increased. It was observed that temperature and injection flow rate were the factors that most contributed to strengthening the bonds of dissimilar materials.
Influence of n-ZnO Morphology on Sulfur Crosslinking and Properties of Styrene-Butadiene Rubber Vulcanizates
Authors: Bieliński Dariusz M. , Klajn Katarzyna , Gozdek Tomasz , Kruszyński Rafał , Świątkowski Marcin
Published: March 2021

This paper examines the influence of the morphology of zinc oxide nanoparticles (n-ZnO) on the activation energy, vulcanization parameters, crosslink density, crosslink structure, and mechanical properties in the extension of the sulfur vulcanizates of styrene-butadiene rubber (SBR). Scanning electron microscopy was used to determine the particle size distribution and morphology, whereas the specific surface area (SSA) and squalene wettability of the n-ZnO nanoparticles were adequately evaluated using the Brunauer–Emmet–Teller (BET) equation and tensiometry. The n-ZnO were then added to the SBR in conventional (CV) or efficient (EV) vulcanization systems. The vulcametric curves were plotted, from which the cure rate index (CRI) rate of the vulcanization and the activation energy were calculated. The influence on the mechanical properties of the SBR vulcanizates was stronger in the case of the EV curing system than when the CV curing system was used. Of the vulcanizates produced in the EV curing system, the best performance was detected for n-ZnO particles with a hybrid morphology (flat-ended rod-like particles on a “cauliflower” base) and high SSA. Vulcanizates produced using the CV curing system showed slightly better mechanical properties after the addition of nanoparticles with a “cauliflower” morphology than when the rod-like type were used, irrespective of their SSA. In general, nanoparticles with a rod-like structure reduced the activation energy and increased the speed of vulcanization, whereas the cauliflower type slowed the rate of the process and the vulcanizates required a higher activation energy, especially when using the EV system. The crosslink structures were also more clearly modified, as manifested by a reduction in the polysulfidic crosslink content, especially when n-ZnO activators with a rod-like morphology were applied.
Physical Effects of Radiation Modification of Biodegradable Xylitol-Based Materials Synthesized Using a Combination of Different Monomers
Authors: Piątek-Hnat Marta , Bomba Kuba , Kowalski-Stankiewicz Janusz P. , Pęksiński Jakub , Kozłowska Agnieszka , Sośnicki Jacek G. , Idzik Tomasz J. , Schmidt Beata , Kowalczyk Krzysztof , Walo Marta , Kochmańska Agnieszka
Published: March 2021

There is a possibility of obtaining xylitol-based elastomers sharing common characteristics of biodegradability, thermal stability, and elastomeric behavior by using monomers with different chain-lengths. Therefore, we have synthesized eight elastomers using a combination of four different diols (ethanediol, 1.3-propanediol, 1.4-buanediol, and 1.5-pentanediol) and two different dicarboxylic acids (succinic acid and adipic acid). The obtained materials were further modified by performing e-beam treatment with a dose of 100 kGy. Materials both before and after radiation modification were tested by DSC, DMTA, TGA, tensile tests, gel fraction determination, hydrolytic and enzymatic degradation tests, 1H NMR and 13C NMR and FTIR.
The Effect of Alkyl Substitution of Novel Imines on Their Supramolecular Organization, towards Photovoltaic Applications
Authors: Nitschke Paweł , Jarząbek Bożena , Vasylieva Marharyta , Godzierz Marcin , Janeczek Henryk , Musioł Marta , Domiński Adrian
Published: March 2021

Three novel conjugated polyazomethines have been obtained by polycondensation of diamines consisting of the diimine system, with either 2,5-bis(octyloxy)terephthalaldehyde or 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde. Partial replacement of bulky solubilizing substituents with the smaller side groups has allowed to investigate the effect of supramolecular organization. All obtained compounds have been subsequently identified using the NMR and FTIR spectroscopies and characterized by the thermogravimetric analysis, differential scanning calorimetry, cyclic voltammetry, UV–Vis spectroscopy, and X-ray diffraction. Investigated polymers have shown a good thermal stability and high glass transition temperatures. X-ray measurements have proven that partial replacement of octyloxy side chains with smaller methoxy groups induced a better planarization of macromolecule. Such modification has tuned the LUMO level of this molecule and caused a bathochromic shift of the lowest energy absorption band. On the contrary, imines consisting of N-ethylhexyl substituted carbazole units have not been so clearly affected by alkyl chain length modification. Photovoltaic activity of imines (acting as a donor) in bulk-heterojunction systems has been observed for almost all studied compounds, blended with the fullerene derivative (PCBM) in various weight ratios.
Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment
Authors: Yu Seungjin , Piao Huiyan , Rejinold N. Sanoj , Jin Geunwoo , Choi Goeun , Choy Jin-Ho
Published: March 2021

Niclosamide (NIC), a conventional anthelmintic agent, is emerging as a repurposed drug for COVID-19 treatment. However, the clinical efficacy is very limited due to its low oral bioavailability resulting from its poor aqueous solubility. In the present study, a new hybrid drug delivery system made of NIC, montmorillonite (MMT), and Tween 60 is proposed to overcome this obstacle. At first, NIC molecules were immobilized into the interlayer space of cationic clay, MMT, to form NIC–MMT hybrids, which could enhance the solubility of NIC, and then the polymer surfactant, Tween 60, was further coated on the external surface of NIC–MMT to improve the release rate and the solubility of NIC and eventually the bioavailability under gastrointestinal condition when orally administered. Finally, we have performed an in vivo pharmacokinetic study to compare the oral bioavailability of NIC for the Tween 60-coated NIC–MMT hybrid with Yomesan®, which is a commercially available NIC. Exceptionally, the Tween 60-coated NIC–MMT hybrid showed higher systemic exposure of NIC than Yomesan®. Therefore, the present NIC–MMT–Tween 60 hybrid can be a potent NIC drug formulation with enhanced solubility and bioavailability in vivo for treating Covid-19.
Fabrication of Oblique Submicron-Scale Structures Using Synchrotron Hard X-ray Lithography
Authors: Kim Kanghyun , Park Kyungjin , Nam Hyoryung , Kim Geon Hwee , Hong Seong Kyung , Kim Suhyeon , Woo Hyeonsu , Yoon Seungbin , Kim Jong Hyun , Lim Geunbae
Published: March 2021

Oblique submicron-scale structures are used in various aspects of research, such as the directional characteristics of dry adhesives and wettability. Although deposition, etching, and lithography techniques are applied to fabricate oblique submicron-scale structures, these approaches have the problem of the controllability or throughput of the structures. Here, we propose a simple X-ray-lithography method, which can control the oblique angle of submicron-scale structures with areas on the centimeter scale. An X-ray mask was fabricated by gold film deposition on slanted structures. Using this mask, oblique ZEP520A photoresist structures with slopes of 20° and 10° and widths of 510 nm and 345 nm were fabricated by oblique X-ray exposure, and the possibility of polydimethylsiloxane (PDMS) molding was also confirmed. In addition, through double exposure with submicron- and micron-scale X-ray masks, dotted-line patterns were produced as an example of multiscale patterning.
Fabrication, Functionalization, and Application of Carbon Nanotube-Reinforced Polymer Composite: An Overview
Authors: Mohd Nurazzi Norizan , Asyraf M.R.M. , Khalina Abdan , Abdullah Norli , Sabaruddin Fatimah Athiyah , Kamarudin Siti Hasnah , Ahmad So’bah , Mahat Annie Maria , Lee Chuan Li , Aisyah H. A. , Norrrahim Mohd Nor Faiz , Ilyas R. A. , Harussani M. M. , Ishak M. R. , Sapuan S. M.
Published: March 2021

A novel class of carbon nanotube (CNT)-based nanomaterials has been surging since 1991 due to their noticeable mechanical and electrical properties, as well as their good electron transport properties. This is evidence that the development of CNT-reinforced polymer composites could contribute in expanding many areas of use, from energy-related devices to structural components. As a promising material with a wide range of applications, their poor solubility in aqueous and organic solvents has hindered the utilizations of CNTs. The current state of research in CNTs—both single-wall carbon nanotubes (SWCNT) and multiwalled carbon nanotube (MWCNT)-reinforced polymer composites—was reviewed in the context of the presently employed covalent and non-covalent functionalization. As such, this overview intends to provide a critical assessment of a surging class of composite materials and unveil the successful development associated with CNT-incorporated polymer composites. The mechanisms related to the mechanical, thermal, and electrical performance of CNT-reinforced polymer composites is also discussed. It is vital to understand how the addition of CNTs in a polymer composite alters the microstructure at the micro- and nano-scale, as well as how these modifications influence overall structural behavior, not only in its as fabricated form but also its functionalization techniques. The technological superiority gained with CNT addition to polymer composites may be advantageous, but scientific values are here to be critically explored for reliable, sustainable, and structural reliability in different industrial needs.
Innovative Magnetite Based Polymeric Nanocomposite for Simultaneous Removal of Methyl Orange and Hexavalent Chromium from Water
Authors: Alsaiari Norah Salem , Amari Abdelfattah , Katubi Khadijah Mohammedsaleh , Alzahrani Fatimah Mohammed , Rebah Faouzi Ben , Tahoon Mohamed A.
Published: March 2021

One of the most important directions for environmental remediation is the effective removal of dyes and toxic heavy metals from water using newly fabricated nanoadsorbents. Here, magnetic Fe3O4 nanoparticles were combined with nitrogen-containing functional group polymers chitosan (CS) and polypyrrole (ppy) to synthesize a nanocomposite (polypyrrole@magnetic chitosan) useful for removing methyl orange (MO) and hexavalent chromium (Cr (VI)) from water. The physicochemical properties of the nanocomposite were determined using SEM, TEM, XRD, FT–IR, and TGA techniques. The effect of different factors on the adsorption system was studied including the contact time, pH, and the effect of co-existed ions. The kinetic study illustrated that the adsorption fit well with Langmuir isotherm. The maximum adsorption capacity of MO and Cr (VI) was found to be 95 and 105 mg/g, respectively. The reusability of the nanocomposite was studied for up to five cycles using 0.1 M NaOH as eluent with a slight decrease of adsorbent efficiency. Furthermore, the removal mechanism studied suggested the removal of MO via adsorption and Cr (VI) via chemical reduction and adsorption. This study suggests that a ppy@magnetic chitosan nanocomposite is a promising nanoadsorbent for removing MO and Cr (VI) from water.
3D Multidisciplinary Automated Design Optimization Toolbox for Wind Turbine Blades
Authors: Sagimbayev Sagi , Kylyshbek Yestay , Batay Sagidolla , Zhao Yong , Fok Sai , Soo Lee Teh
Published: March 2021

This paper presents two novel automated optimization approaches. The first one proposes a framework to optimize wind turbine blades by integrating multidisciplinary 3D parametric modeling, a physics-based optimization scheme, the Inverse Blade Element Momentum (IBEM) method, and 3D Reynolds-averaged Navier–Stokes (RANS) simulation; the second method introduces a framework combining 3D parametric modeling and an integrated goal-driven optimization together with a 4D Unsteady Reynolds-averaged Navier–Stokes (URANS) solver. In the first approach, the optimization toolbox operates concurrently with the other software packages through scripts. The automated optimization process modifies the parametric model of the blade by decreasing the twist angle and increasing the local angle of attack (AoA) across the blade at locations with lower than maximum 3D lift/drag ratio until a maximum mean lift/drag ratio for the whole blade is found. This process exploits the 3D stall delay, which is often ignored in the regular 2D BEM approach. The second approach focuses on the shape optimization of individual cross-sections where the shape near the trailing edge is adjusted to achieve high power output, using a goal-driven optimization toolbox verified by 4D URANS Computational Fluid Dynamics (CFD) simulation for the whole rotor. The results obtained from the case study indicate that (1) the 4D URANS whole rotor simulation in the second approach generates more accurate results than the 3D RANS single blade simulation with periodic boundary conditions; (2) the second approach of the framework can automatically produce the blade geometry that satisfies the optimization objective, while the first approach is less desirable as the 3D stall delay is not prominent enough to be fruitfully exploited for this particular case study.
Non-Immersion Ultrasonic Cleaning: An Efficient Green Process for Large Surfaces with Low Water Consumption
Authors: Sarasua Miranda Jon Ander , Ruiz-Rubio Leire , Aranzabe Basterrechea Estibaliz , Vilas-Vilela Jose Luis
Published: March 2021

Ultrasonic cleaning is a developed and widespread technology used in the cleaning industry. The key to its success over other cleaning methods lies in its capacity to penetrate seemingly inaccessible, hard-to-reach corners, cleaning them successfully. However, its major drawback is the need to immerse the product into a tank, making it impossible to work with large or anchored elements. With the aim of revealing the scope of the technology, this paper will attempt to describe a more innovative approach to cleaning large area surfaces (walls, floors, façades, etc.) which involves applying ultrasonic cavitation onto a thin film of water, which is then deposited onto a dirty surface. Ultrasonic cleaning is an example of the proliferation of green technology, requiring 15 times less water and 115 times less power than conventional high-pressurized waterjet cleaning mechanisms. This paper will account for the physical phenomena that govern this new cleaning mechanism and the competition it poses towards more conventional pressurized waterjet technology. Being easy to use as a measure of success, specular surface cleaning has been selected to measure the degree of cleanliness (reflectance) as a function of the process’s parameters. A design of experiments has been developed in line with the main process parameters: amplitude, gap, and sweeping speed. Regression models have also been used to interpret the results for different degrees of soiling. The work concludes with the finding that the proposed new cleaning technology and process can reach up to 98% total cleanliness, without the use of any chemical product and with very low water and power consumption.