bluuebunny/crossref_metadata_2025 huggingface dataset:
The Hilbert space of de Sitter quantum gravity
Authors: Chakraborty Tuneer , Chakravarty Joydeep , Godet Victor , Paul Priyadarshi , Raju Suvrat
Published: January 2024

Abstract

We obtain solutions of the Wheeler-DeWitt equation with positive cosmological constant for a closed universe in the large-volume limit. We argue that this space of solutions provides a complete basis for the Hilbert space of quantum gravity in an asymptotically de Sitter spacetime. Our solutions take the form of a universal phase factor multiplied by distinct diffeomorphism invariant functionals, with simple Weyl transformation properties, that obey the same Ward identities as a CFT partition function. The Euclidean vacuum corresponds to a specific choice of such a functional but other choices are equally valid. Each functional can be thought of as specifying a “theory” and, in this sense, the space of solutions is like “theory space”. We describe another basis for the Hilbert space where all states are represented as excitations of the vacuum that have a specific constrained structure. This gives the finite GN generalization of the basis proposed by Higuchi in terms of group averaging, which we recover in the nongravitational limit.
Primordial black holes as dark matter: interferometric tests of phase transition origin
Authors: Baldes Iason , Olea-Romacho María Olalla
Published: January 2024

Abstract

We show that primordial black holes — in the observationally allowed mass window with fPBH = 1 — formed from late nucleating patches in a first order phase transition imply upcoming gravitational wave interferometers will see a large stochastic background arising from the bubble collisions. As an example, we use a classically scale invariant B – L model, in which the right handed neutrinos explain the neutrino masses and leptogenesis, and the dark matter consists of primordial black holes. The conclusion regarding the gravitational waves is, however, expected to hold model independently for black holes coming from such late nucleating patches.
Cut elimination for coherent theories in negation normal form
Authors: Maffezioli Paolo
Published: January 2024

We present a cut-free sequent calculus for a class of first-order theories in negation normal form which include coherent and co-coherent theories alike. All structural rules, including cut, are admissible.
Polyether Ketone Ketone (PEKK) matrix composites for material extrusion additive manufacturing
Authors: Rashed Kaifur , Kafi Abdullah , Simons Ranya , Dell’Olio Mel , Bateman Stuart
Published: January 2024

Despite the widespread use of fused filament fabrication (FFF) (an extrusion-based additive manufacturing process) to manufacture end-use parts for the aerospace industry, limited materials are available within this process that can be used for structural applications in the harsh space environment. Currently available high-performance polymers need to be improved by incorporating additives within the polymer matrix to achieve multi-functional properties. Additives such as graphene, graphene oxide, carbon nanotubes and boron carbide are known to improve mechanical and thermal properties and radiation shielding. This study aims to understand if these additives can be successfully incorporated into PEKK matrix to manufacture printable filaments for FFF. Graphene, graphene oxide (GO) and boron carbide (B4C) were compatibilised with PEKK matrix, and their mechanical, thermal and rheological properties were analysed and compared with commercially available carbon fibre and carbon nanotube-reinforced PEKK where appropriate. As rheological properties of the formulations confirmed that they were printable, filaments for FFF were then manufactured. Graphene–PEKK was the most printable filament followed by GO–PEKK while B4C–PEKK was not printable. TEM images of filament cross-section showed good dispersion of graphene and graphene oxide, while boron carbide formed large agglomerates; B4C also presented feeding issues due to its hardness which affected its printability. Dispersion of the additives was also confirmed by studying their X-ray diffraction (XRD) patterns, and chemical structures were assessed using FT-IR spectroscopy. Finally, parts were printed using selected composite filaments, and their porosity and surface roughness were compared with neat PEKK and commercial CNT-reinforced PEKK to develop an understanding of metrology and bulk material properties of the composites.
Mid-term Clinical Outcome of Microvascular Gracilis Muscle Flaps for Defects of the Hand
Authors: Pastor Tatjana , Meier Rahel , Merky Dominique , Haug Luzian , Pastor Torsten , Zubler Cédric , Vögelin Esther
Published: January 2024

Purpose: Gracilis muscle flaps are useful to cover defects of the hand. However, there are currently no studies describing outcome measurements after covering soft tissue defects using free flaps in the hand. Aim: To analyze mid-term results of gracilis muscle flap coverage for defects on the hand, with regard to functional and esthetic integrity. Methods: 16 patients aged 44.3 (range 20–70) years were re-examined after a mean follow-up of 23.6 (range 2–77) months. Mean defect size was 124 (range 52–300) cm2 located palmar (n = 9), dorsal (n = 6), or radial (n = 1). All flaps were performed as microvascular muscle flaps, covered by split thickness skin graft. Results: Flaps survived in 15 patients. 6 patients required reoperations. Reasons for revisions were venous anastomosis failure with total flap loss (n = 1) requiring a second gracilis muscle flap; necrosis at the tip of the flap (n = 1) with renewed split thickness skin cover. A surplus of the flap (n = 2) required flap thinning and scar corrections were performed in 2 patients. Mean grip strength was 25% (range 33.3–96.4%) compared to the contralateral side and mean patient-reported satisfaction 1.4 (range 1–3) (1 = excellent; 4 = poor). Conclusions: Gracilis muscle flaps showed a survival rate of 94%. Patients showed good clinical outcomes with acceptable wrist movements and grip strength as well as high reported satisfaction rates. Compared to fasciocutaneous free flaps, pliability and thinness especially on the palmar aspect of the hand are advantageous. Hence, covering large defects of the hand with a gracilis muscle flap can be a very satisfactory procedure.

Level of evidence: IV observational.
Genetic analysis of late-maturity α-amylase in twelve wheat populations
Authors: Fairlie William , Norman Adam , Edwards James , Mather Diane E. , Kuchel Haydn
Published: January 2024

Main conclusion

Genetic loci, particularly those with an effect in the independent panel, could be utilised to further reduce LMA expression when used with favourable combinations of genes known to affect LMA.

Late maturity α-amylase (LMA) is a grain quality defect involving elevated α-amylase within the aleurone of wheat (Triticum aestivum L.) grains. The genes known to affect expression are the reduced height genes Rht-B1 (chromosome 4B) and Rht-D1 (chromosome 4D), and an ent-copalyl diphosphate synthase gene (LMA-1) on chromosome 7B. Other minor effect loci have been reported, but these are poorly characterised and further genetic understanding is needed. In this study, twelve F4-derived populations were created through single seed descent, genotyped and evaluated for LMA. LMA-1 haplotype C and the Rht-D1b allele substantially reduced LMA expression. The alternative dwarfing genes Rht13 and Rht18 had no significant effect on LMA expression. Additional quantitative trait loci (QTL) were mapped at 16 positions in the wheat genome. Effects on LMA expression were detected for four of these QTL in a large independent panel of Australian wheat lines. The QTL detected in mapping populations and confirmed in the large independent panel provide further opportunity for selection against LMA, especially if combined with Rht-D1b and/or favourable haplotypes of LMA-1.
Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes
Authors: Schmidt Julia , Kaulfuß Silke , Ott Hagen , Gaubert Marianne , Reintjes Nadine , Bremmer Felix , Dreha-Kulaczewski Steffi , Stroebel Philipp , Yigit Gökhan , Wollnik Bernd
Published: January 2024

The fibroblast growth factor receptors comprise a family of related but individually distinct tyrosine kinase receptors. Within this family, FGFR2 is a key regulator in many biological processes, e.g., cell proliferation, tumorigenesis, metastasis, and angiogenesis. Heterozygous activating non-mosaic germline variants in FGFR2 have been linked to numerous autosomal dominantly inherited disorders including several craniosynostoses and skeletal dysplasia syndromes. We report on a girl with cutaneous nevi, ocular malformations, macrocephaly, mild developmental delay, and the initial clinical diagnosis of Schimmelpenning–Feuerstein–Mims syndrome, a very rare mosaic neurocutaneous disorder caused by postzygotic missense variants in HRAS, KRAS, and NRAS. Exome sequencing of blood and affected skin tissue identified the mosaic variant c.1647=/T > G p.(Asn549=/Lys) in FGFR2, upstream of the RAS signaling pathway. The variant is located in the tyrosine kinase domain of FGFR2 in a region that regulates the activity of the receptor and structural mapping and functional characterization revealed that it results in constitutive receptor activation. Overall, our findings indicate FGFR2-associated neurocutaneous syndrome as the accurate clinical-molecular diagnosis for the reported individual, and thereby expand the complex genotypic and phenotypic spectrum of FGFR-associated disorders. We conclude that molecular analysis of FGFR2 should be considered in the genetic workup of individuals with the clinical suspicion of a mosaic neurocutaneous condition, as the knowledge of the molecular cause might have relevant implications for genetic counseling, prognosis, tumor surveillance and potential treatment options.
Non-alcoholic fatty liver disease in patients with morbid obesity: the gut microbiota axis as a potential pathophysiology mechanism
Authors: Cornejo-Pareja Isabel , Amiar Mohamed Reda , Ocaña-Wilhelmi Luís , Soler-Humanes Rocío , Arranz-Salas Isabel , Garrido-Sánchez Lourdes , Gutiérrez-Repiso Carolina , Tinahones Francisco Jose
Published: January 2024

Background/aim

Alterations in gut microbiota are associated with the pathogenesis of metabolic diseases, including metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate gut microbiota composition and functionality in patients with morbid obesity with different degrees of MAFLD, as assessed by biopsy.

Subjects/methods

110 patients with morbid obesity were evaluated by biopsy obtained during bariatric surgery for MAFLD. Stool samples were collected prior to surgery for microbiota analysis.

Results

Gut microbiota from patients with steatosis and non-alcoholic steatohepatitis (NASH) were characterized by an enrichment in Enterobacteriaceae (an ethanol-producing bacteria), Acidaminococcus and Megasphaera and the depletion of Eggerthellaceae and Ruminococcaceae (SCFA-producing bacteria). MAFLD was also associated with enrichment of pathways related to proteinogenic amino acid degradation, succinate production, menaquinol-7 (K2-vitamin) biosynthesis, and saccharolytic and proteolytic fermentation. Basic histological hepatic alterations (steatosis, necroinflammatory activity, or fibrosis) were associated with specific changes in microbiota patterns. Overall, the core microbiome related to basic histological alterations in MAFLD showed an increase in Enterobacteriaceae and a decrease in Ruminococcaceae. Specifically, Escherichia coli was associated with steatosis and necroinflammatory activity, whilst Escherichia-shigella was associated with fibrosis and necroinflammatory activity.

Conclusions

We established a link between gut microbiota alterations and histological injury in liver diagnosis using biopsy. Harmful products such as ethanol or succinate may be involved in the pathogenesis and progression of MAFLD. Thus, these alterations in gut microbiota patterns and their possible metabolic pathways could add information to the classical predictors of MAFLD severity and suggest novel metabolic targets.
Experimental study of long-term catalytic effect on hydrogen generation G value of water by gamma-ray irradiation and hydrogen diffusion analysis in Compacted Hulls and End-Piece waste
Authors: Eto Junji , Kawai Masaki , Matsumoto Masaaki , Tanaka Hirohisa , Hino Ryutaro , Terada Atsuhiko , Taniguchi Masashi , Sugiyama Hitoshi
Published: January 2024

In this study, it was evaluated the long-term catalytic effect and catalyst poisoning effect of gamma-ray irradiation on zirconium molybdate hydrate in the presence of three-way catalysts. The results indicated that the three-way catalyst was effective in suppressing the increase in hydrogen concentration due to radiolysis without being affected by poisoning. In addition, hydrogen diffusion analysis of the compressed hull and endpiece waste shows that hydrogen flows well through the waste and is suppressed by a three-way catalyst located in the center of the waste headspace.
Linking the future likelihood of large fires to occur on mountain slopes with fuel connectivity and topography
Authors: Conedera Marco , Feusi Jeremy , Pezzatti Gianni Boris , Krebs Patrik
Published: January 2024

In the long run, ongoing climate change is expected to alter fuel production as well as the frequency and severity of fire weather, which may result in an unprecedented frequency of extreme fire events. In this paper we propose a simplified and spatially explicit method to assess the probability of experiencing large fires, based on topography (slope length) as well as extent and aggregation of the forested area (fuel connectivity). We considered 21 homogeneous pyroregions covering entire Switzerland as a study case and computed the length of the upslope paths within the forested areas, simulating ignition points on a systematic 100 × 100 m square grid. We then compared the obtained path lengths for each pyroregion with selected historical large forest fire statistics (e.g., mean area of the largest 5% of fires, maximum burnt area per fire) collected over the course of the last 30 years. This resulted in rather high R2 values, ranging from 0.558 to 0.651. The proposed approach was shown to allow for an easy identification and geo-localization of potential hotspots in terms of the likelihood for large fires to occur in mountainous regions, which is a prerequisite for a targeted planning of fire management measures aimed at preventing large fires and related post-fire gravitative natural hazards.
Enhancing catalytic performance, coke resistance, and stability with strontium-promoted Ni/WO3-ZrO2 catalysts for methane dry reforming
Authors: Elnour Ahmed Yagoub , Fakeeha Anis Hamza , Ibrahim Ahmed Aidid , Osman Ahmed I. , Abasaeed Ahmed Elhag , Adil Syed Farooq , Kumar Rawesh , Al-Fatesh Ahmed S.
Published: January 2024

The first step of the DRM reaction is just the decomposition of CH4 into CH4−x (x = 1–4). The next step comprises two steps, namely the oxidation of CH4−x into syngas (by CO2) and the self-polymerization of CH4−x species. The earlier one is known as dry reforming of methane (DRM), and the latter one generates carbon deposits over the catalyst surface. In this study, we investigated the impact of 1–3 wt% Sr over Ni-based catalysts on a ZrO2-WO3 support on the catalytic activity and coke deposit. Various characterization techniques such as thermogravimetric analysis, X-ray diffraction, Raman spectroscopy, temperature-programed oxidation, temperature-programed reduction, and temperature-programed desorption were used to assess the physicochemical properties of the fresh and spent catalysts. The addition of 2wt% Sr promoter significantly improves the catalyst’s basicity in strong basic sites region through Sr2+ mediated interaction of CO2 species as well as inhibits the deposition of carbyne type carbon. Enhanced CO2 interaction results into the potential oxidation of carbon deposit and the highest CH4 conversion, reaching 60% up to 470 min TOS at a reaction temperature of 700 ℃.

Graphical abstract
The Effect of Social Cohesion on Subjective Individual Quality of Life in European Countries
Authors: Bottoni Gianmaria , Addeo Felice
Published: January 2024

Many scholars have studied the effects of economic conditions on subjective well-being, but scarce attention has been paid to the effect of cultural and social determinants on quality of life. This study aims to analyse the effect of social cohesion considered as a characteristic of a country on subjective quality of life. In addition, we also tested the moderating effect of social cohesion on the relationship between income and placement in society with quality of life. To test our hypotheses we estimated a multilevel regression model. First, we estimated the null model, which showed that almost a quarter of the variance in quality of life is located at country level. Second, we included in the model all the level-1 predictors. This model highlighted that self-evaluated position on the social ladder has a larger positive effect than income on quality of life. In the third step, we added country-level predictors. Controlling for other macro factors—GDP, Life Expectancy, Gini coefficient and Homicide rate—and individual-level variables, we shows that Cohesion exerts a positive effect on subjective quality of life. The model also points out that country’s economic conditions (measured by GDP) do not affect quality of life when we control this relationship for social cohesion. Interestingly, also the within-country economic disparities (measured by Gini coefficient) do not seem to affect quality of life when cohesion is taken into account. Finally, we also shows that the positive effect of income on quality of life is moderated by cohesion. In other words, income is a relatively less important factor in determining quality of life in countries with higher levels of cohesion. In the same way, individuals’ position and perception of their placement on the social ladder affects in a lesser extent their quality of life in those countries that have higher degrees of cohesion.
Classifying patients with psoriatic arthritis according to their disease activity status using serum metabolites and machine learning
Authors: Koussiouris John , Looby Nikita , Kotlyar Max , Kulasingam Vathany , Jurisica Igor , Chandran Vinod
Published: January 2024

Introduction

Psoriatic arthritis (PsA) is a heterogeneous inflammatory arthritis, affecting approximately a quarter of patients with psoriasis. Accurate assessment of disease activity is difficult. There are currently no clinically validated biomarkers to stratify PsA patients based on their disease activity, which is important for improving clinical management.

Objectives

To identify metabolites capable of classifying patients with PsA according to their disease activity.

Methods

An in-house solid-phase microextraction (SPME)—liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for lipid analysis was used to analyze serum samples obtained from patients classified as having low (n = 134), moderate (n = 134) or high (n = 104) disease activity, based on psoriatic arthritis disease activity scores (PASDAS). Metabolite data were analyzed using eight machine learning methods to predict disease activity levels. Top performing methods were selected based on area under the curve (AUC) and significance.

Results

The best model for predicting high disease activity from low disease activity achieved AUC 0.818. The best model for predicting high disease activity from moderate disease activity achieved AUC 0.74. The best model for classifying low disease activity from moderate and high disease activity achieved AUC 0.765. Compounds confirmed by MS/MS validation included metabolites from diverse compound classes such as sphingolipids, phosphatidylcholines and carboxylic acids.

Conclusion

Several lipids and other metabolites when combined in classifying models predict high disease activity from both low and moderate disease activity. Lipids of key interest included lysophosphatidylcholine and sphingomyelin. Quantitative MS assays based on selected reaction monitoring, are required to quantify the candidate biomarkers identified.
Tikhonov Regularization for the Fully Coupled Integral Method of Incremental Hole-Drilling
Authors: Smit T. C. , Reid R.G.
Published: January 2024

Background

The unit pulse integral method is used extensively with the incremental hole-drilling residual stress measurement technique. The ASTM E837 standard, which applies only to isotropic materials, recommends the use of Tikhonov regularization to reduce instability when many depth increments are used. In its current formulation, Tikhonov regularization requires the decoupling of stress, as is possible for isotropic materials. The fully coupled integral method is needed for residual stress determination in layered composite laminates and is currently employed without Tikhonov regularization. This causes greater sensitivity to measurement errors and consequently large stress uncertainties. An approximate method of applying Tikhonov regularization exists for biaxial composites, but is not applicable to more complex laminates.

Objective

Extend Tikhonov regularization to the fully coupled integral method to improve residual stress determination in composite laminates.

Methods

This work investigates the use of the approximate and fully coupled regularization approaches in an angle ply composite laminate of [+45/-45/0/90]s construction. Experimental validation in a [0/+45/90/-45]s laminate is also presented where the regularized fully coupled integral method is compared to the series expansion method that includes all in-plane stress and strain directions simultaneously in a least-squares solution.

Results

The regularized integral method produces comparable results to those of series expansion while requiring twelve times less FE computation to calculate the compliances. The optimal degree of regularization is also more convenient to determine than the optimal combination of series order required by series expansion.

Conclusions

The new method is easily applied and should find wide application in the measurement of residual stresses in composite laminates.
Anaphylaxis as probable cause of death in a rare case of fatal Vipera berus bite
Authors: Mittendorf Anton F. , Winskog Carl
Published: January 2024

This case report describes the death of a 52-year-old male who was bitten by a venomous snake, Vipera berus (common European adder), on his left wrist. Despite experiencing symptoms, the patient refused medical care and self-medicated with alcohol instead. He was later found dead in his residence. Autopsy and histological examination revealed evidence of an anaphylactic reaction in response to the snake bite, with additional findings of alcohol intoxication and other underlying medical conditions.
A post-emergence herbicide program for weedy sunflower (Helianthus annuus L.) control in maize
Authors: Brankov Milan , Simić Milena , Piskackova Theresa , Zarić Miloš , Rajković Miloš , Pavlović Natalija , Dragičević Vesna
Published: January 2024

During the last 15 years in Serbia, there has been an invasion of H. annuus across the country. Plants were initially limited to non-cultivated areas near arable fields, while in recent years the species has started to occur and establish populations in crop fields, especially into wide-row crops. We tested eight herbicides in two greenhouse experiments: 1) a dose-response study; 2) an efficacy study with reduced herbicide rates adding an adjuvant. The tested herbicides showed satisfactory weed control, where all estimated effective doses 90 (ED90) were lower than the recommended field rate for each herbicide, except for dicamba. The addition of non-ionic surfactants significantly increased the efficacy of glyphosate, mesotrione, rimsulfuron, and foramsulfuron. Whereas, there was no clear advantage to adding an adjuvant to bentazone and tembotrione, as the H. annuus population was already very sensitive (plants died in 1/8 of recommended rate in a dose-response study). All tested herbicides, except dicamba, can be used for satisfactory H. annuus control in maize, while glyphosate can be used for control of the species in non-agricultural lands.
On smooth functions with two critical values
Authors: Lerario Antonio , Meroni Chiara , Zuddas Daniele
Published: January 2024

We prove that every smooth closed connected manifold admits a smooth real-valued function with only two critical values such that the set of minima (or maxima) can be arbitrarily prescribed, as soon as this set is a finite subcomplex of the manifold (we call a function of this type a Reeb function). In analogy with Reeb’s Sphere Theorem, we use such functions to study the topology of the underlying manifold. In dimension 3, we give a characterization of manifolds having a Heegaard splitting of genus g in terms of the existence of certain Reeb functions. Similar results are proved in dimension $$n\ge 5$$

n
≥
5

.
Bacterial contamination of air and surfaces during dental procedures—An experimental pilot study using Staphylococcus aureus
Authors: Franz Jessica , Scheier Thomas C. , Aerni Maja , Gubler Andrea , Schreiber Peter W. , Brugger Silvio D. , Schmidlin Patrick R.
Published: January 2024

Objective:

The oral cavity contains numerous microorganisms, including antimicrobial-resistant bacteria. These microorganisms can be transmitted via respiratory particles from patients to healthcare providers and vice versa during dental care. We evaluated the spread of Staphylococcus aureus during standardized dental procedures using different scaling devices and rinsing solutions.

Methods:

During systematic therapy for dental biofilm removal (guided biofilm therapy), using an airflow or ultrasound device to a model simulation head. Staphylococcus aureus suspension was injected into the mouth of the model to mimic saliva. Different suction devices (conventional saliva ejector or a prototype) and rising solutions (water or chlorhexidine) were used. To assess contamination with S. aureus, an air-sampling device was placed near the oral cavity and samples of surface areas were collected.

Results:

S. aureus was only detected by air sampling when the conventional saliva ejector with airflow was used. No growth was observed during treatments with the ultrasonic piezo instrument or the prototype suction device. Notably, a rinsing solution of chlorhexidine digluconate decreased the bacterial load compared to water. Surface contamination was rarely detected (1 of 120 samples).

Conclusions:

Although our findings indicate potential airborne bacterial transmission during routine prophylactic procedures, specific treatment options during biofilm removal appear to reduce air contamination. These options include ultrasonic piezo devices or the prototype suction device. The use of chlorhexidine reduced the CFU counts of S. aureus detected by air sampling. Surface contamination during dental procedures was a rare occurrence.
Choosing, rejecting, and closely replicating, 30 years later: A commentary on Chandrashekar et al.
Authors: Shafir Eldar , Cheek Nathan N.
Published: January 2024

In a ‘very close replication’ study using the same attributes as the original, Chandrashekar et al. (2021) report a failure to replicate some choose–reject problems documented in Shafir (1993). We find that several of the original attributes have changed their valence three decades later, and we compose new versions with updated attributes that fully replicate Shafir’s (1993) original findings. Despite their apparent exactitude, ‘very close replications’ across contexts or time, when stimuli may have changed their meaning or valence, can be highly misleading, further exacerbating replication concerns.
Enterococcus contamination of infant foods and implications for exposure to foodborne pathogens in peri-urban neighbourhoods of Kisumu, Kenya
Authors: Gutema Fanta D. , Cumming Oliver , Mumma Jane , Simiyu Sheillah , Attitwa Edwin , Okoth Bonphace , Denge John , Sewell Daniel , Baker Kelly K.
Published: January 2024

We collected infant food samples from 714 households in Kisumu, Kenya, and estimated the prevalence and concentration of Enterococcus, an indicator of food hygiene conditions. In a subset of 212 households, we quantified the change in concentration in stored food between a morning and afternoon feeding time. In addition, household socioeconomic characteristics and hygiene practices of the caregivers were documented. The prevalence of Enterococcus in infant foods was 50% (95% confidence interval: 46.1 - 53.4), and the mean log10 colony-forming units (CFUs) was 1.1 (SD + 1.4). No risk factors were significantly associated with the prevalence and concentration of Enterococcus in infant foods. The mean log10 CFU of Enterococcus concentration was 0.47 in the morning and 0.73 in the afternoon foods with a 0.64 log10 mean increase in matched samples during storage. Although no factors were statistically associated with the prevalence and the concentration of Enterococcus in infant foods, household flooring type was significantly associated with an increase in concentration during storage, with finished floors leading to 1.5 times higher odds of concentration increase compared to unfinished floors. Our study revealed high prevalence but low concentration of Enterococcus in infant food in low-income Kisumu households, although concentrations increased during storage implying potential increases in risk of exposure to foodborne pathogens over a day. Further studies aiming at investigating contamination of infant foods with pathogenic organisms and identifying effective mitigation measures are required to ensure infant food safety.
A systematic review of AI-based automated written feedback research
Authors: Shi Huawei , Aryadoust Vahid
Published: January 2024

In recent years, automated written feedback (AWF) has gained popularity in language learning and teaching as a form of artificial intelligence (AI). The present study aimed at providing a comprehensive state-of-the-art review of AWF. Using Scopus as the main database, we identified 83 SSCI-indexed published articles on AWF (1993–2022). We investigated several main domains consisting of research contexts, AWF systems, feedback focus, ways of utilizing AWF, research design, foci of investigation, and results. Our results showed that although AWF was primarily studied in language and writing classes at the tertiary level, with a focus on English as the target language, the scope of AWF research has been steadily broadening to include diverse language environments and ecological settings. This heterogeneity was also demonstrated by the wide range of AWF systems employed (n = 31), ways of integrating AWF (n = 14), different types of AWF examined (n = 3), as well as varied research designs. In addition, three main foci of investigation were delineated: (1) the performance of AWF; (2) perceptions, uses, engagement with AWF, and influencing factors; and (3) the impact of AWF. We identified positive, negative, neutral, and mixed results in all three main foci of investigation. Overall, less positive results were found in validating AWF compared to results favoring the other two areas. Lastly, we grounded our findings within the argument-based validity framework and also examined the potential implications.
Discrepancies between self- and informant-ratings of functional abilities and objective cognition: predictors of bias in mild cognitive impairment
Authors: De Wit Liselotte , Goldstein Felicia C. , Saurman Jessica L. , Rodriguez Amy D. , Vickers Kayci L.
Published: January 2024

Objective:

Self- and informant-ratings of functional abilities are used to diagnose mild cognitive impairment (MCI) and are commonly measured in clinical trials. Ratings are assumed to be accurate, yet they are subject to biases. Biases in self-ratings have been found in individuals with dementia who are older and more depressed and in caregivers with higher distress, burden, and education. This study aimed to extend prior findings using an objective approach to identify determinants of bias in ratings.

Method:

Participants were 118 individuals with MCI and their informants. Three discrepancy variables were generated including the discrepancies between (1) self- and informant-rated functional status, (2) informant-rated functional status and objective cognition (in those with MCI), and (3) self-rated functional status and objective cognition. These variables served as dependent variables in forward linear regression models, with demographics, stress, burden, depression, and self-efficacy as predictors.

Results:

Informants with higher stress rated individuals with MCI as having worse functional abilities relative to objective cognition. Individuals with MCI with worse self-efficacy rated their functional abilities as being worse compared to objective cognition. Informant-ratings were worse than self-ratings for informants with higher stress and individuals with MCI with higher self-efficacy.

Conclusion:

This study highlights biases in subjective ratings of functional abilities in MCI. The risk for relative underreporting of functional abilities by individuals with higher stress levels aligns with previous research. Bias in individuals with MCI with higher self-efficacy may be due to anosognosia. Findings have implications for the use of subjective ratings for diagnostic purposes and as outcome measures.
Communicating with families of young people with hard-to-treat cancers: Healthcare professionals’ perspectives on challenges, skills, and training
Authors: Kelada Lauren , Robertson Eden G. , McKay Skye , McGill Brittany C. , Daly Rebecca , Mazariego Carolyn , Taylor Natalie , Tyedmers Elijah , Armitage Nicole , Evans Holly E. , Wakefield Claire E. , Ziegler David S.
Published: January 2024

Objectives

Hard-to-treat childhood cancers are those where standard treatment options do not exist and the prognosis is poor. Healthcare professionals (HCPs) are responsible for communicating with families about prognosis and complex experimental treatments. We aimed to identify HCPs’ key challenges and skills required when communicating with families about hard-to-treat cancers and their perceptions of communication-related training.

Methods

We interviewed Australian HCPs who had direct responsibilities in managing children/adolescents with hard-to-treat cancer within the past 24 months. Interviews were analyzed using qualitative content analysis.

Results

We interviewed 10 oncologists, 7 nurses, and 3 social workers. HCPs identified several challenges for communication with families including: balancing information provision while maintaining realistic hope; managing their own uncertainty; and nurses and social workers being underutilized during conversations with families, despite widespread preferences for multidisciplinary teamwork. HCPs perceived that making themselves available to families, empowering them to ask questions, and repeating information helped to establish and maintain trusting relationships with families. Half the HCPs reported receiving no formal training for communicating prognosis and treatment options with families of children with hard-to-treat cancers. Nurses, social workers, and less experienced oncologists supported the development of communication training resources, more so than more experienced oncologists.

Significance of results

Resources are needed which support HCPs to communicate with families of children with hard-to-treat cancers. Such resources may be particularly beneficial for junior oncologists and other HCPs during their training, and they should aim to prepare them for common challenges and foster greater multidisciplinary collaboration.
The Thunderstorms With the Greatest Lightning Densities on Earth
Authors: Peterson Michael
Published: January 2024

The most intense thunderstorms on Earth were surveyed using the comprehensive meteorological instrumentation on the Tropical Rainfall Measuring Mission (TRMM) satellite. Expansive land‐based Mesoscale Convective Systems (MCSs) were consistently identified among the Earth's most intense thunderstorms, with their organization into many convective cells spanning a large areal extent permitting exceptional overall flash rates for these storms. In this study, we identify a new class of extreme thunderstorm. Lightning‐dense thunderstorms are relatively compact convective storms whose concentrated lightning activity hinders our ability to accurately measure their flash rates. The top storms have a flash rate of one flash spanning many seconds, as there is insufficient separation to distinguish one flash from another. While any particularly active convective cell could be capable of producing high lightning densities, we find that thunderstorms with the greatest lightning densities on Earth are found in maritime thunderstorms that have not been appreciated in prior work due to the inaccurate flash rate measurements. These storms that are mostly found throughout the Gulf of Mexico and east of South Africa (among other coastal and oceanic regions) have measured TRMM proxies for convective intensity that rival the top MCS thunderstorms, but their horizontal and vertical dimensions are small by comparison. Thus, the necessary microphysical elements for electrification processes are more highly concentrated, enabling the observed extreme lightning densities.
Waterborne Virus Transport and Risk Assessment in Lake Geneva Under Climate Change
Authors: Li Chaojie , Kohn Tamar
Published: January 2024

Climate changes influence lake hydrodynamics and radiation levels and thus may affect the fate and transport of waterborne pathogens in lakes. This study examines the impact of climate change on the fate, transport, and associated risks of four waterborne viruses in Lake Geneva. We used a coupled water quality‐microbial risk assessment model to estimate virus concentrations and associated risks to recreational water users for each month in 2019 and 2060. Long‐term hydrodynamic simulations suggested that although the annual hydrodynamic transport pattern of Lake Geneva will remain relatively stable, a 1.9°C increase of lake surface water temperature can be expected, while a slight decrease in lake current velocity may occur. The subsequent effect on the fate and transport of the four enteric viruses was found to vary by time of year. During warmer periods, the increase of virus inactivation due to higher water temperature and stronger solar radiation at the earth's surface will compensate for the additional virus discharge brought about by population growth over the time period considered, whereas during winter the virus concentration near the lake shore and the associated infection probabilities risks are likely to increase due to population growth. Additionally, the current estimation of virus inactivation rate shows significant variability, which has a more substantial effect on enteric virus concentrations in the lake compared with changing climate parameters. Overall, the study suggests that future risks posed by enteric viruses with recreational water users near popular beaches around Lake Geneva will likely remain similar to current risks and accurate estimation of the environmental inactivation of viruses is crucial for predicting the fate of enteric viruses in the aquatic system.
Urbanization Amplified Compound Hot Extremes Over the Three Major Urban Agglomerations in China
Authors: Lin Xin , Wang Yujie , Song Lianchun
Published: January 2024

Understanding how urbanization affects compound hot extremes (CHEs) is important for the sustainable development in urban agglomeration under global warming. In this study, we investigate the changes of CHEs in summer over the Beijing‐Tianjin‐Hebei region (BTH), Yangtze River Delta (YRD) and Pearl River Delta (PRD) in China, and assess the effects of urbanization on these changes. We find that the frequency and intensity of CHEs in summer show significantly increasing trends in these agglomerations in the recent five decades, particularly in megacities such as Beijing, Shanghai, Guangzhou and Tianjin. The urbanization contributions to CHEs in the YRD and PRD were estimated to 36 ∼ 58%, while relatively small in the BTH, ranging 16 ∼ 29%. They were bonded to the unban size, expansion speed and local climate. In addition to global warming and urbanization, the strengthening continental high and enhancing Western Pacific Subtropical High and its westward displacement were favor to the increased CHEs.
Prediction of Ionograms With/Without Spread‐F at Hainan by a Combined Spatio‐Temporal Neural Network
Authors: Gao Pengdong , Cai Jinhui , Wang Zheng , Qiu Chu , Wang Guojun , Qi Quan , Wang Bo , Shi Jiankui , Wang Xiao , Ding Kai
Published: January 2024

An intelligent high‐definition and short‐term prediction of ionograms with/without Spread‐F for the observation at Hainan (19.5°N, 109.1°E, magnetic 11°N) is presented in this paper, which comprises a spatio‐temporal ConvGRU network and a super‐resolution EDSR network. Our prediction is based on spatio‐temporal features in the ionogram graph only. There are 469,227 ionograms classified into 5 categories, that is, frequency/range/mix/strong range/no Spread F, over a solar cycle (14 years) labeled manually by the research group, and we process these ionograms into two data sets for training the two networks mentioned above. A series of comprehensive experiments have been designed and conducted to determine the optimal super‐parameters. Our method inputs 8 consecutive authentic ionograms (lasting 2 hr) and generates the next 2 figures (next 30 min). Remarkably, all predicted figures achieve a high accuracy rate of over 94% in predicting the occurrence of Spread‐F.
Effects of reduced sedentary time on resting, exercise and post-exercise blood pressure in inactive adults with metabolic syndrome – a six-month exploratory RCT
Authors: Norha Jooa , Sjöros Tanja , Garthwaite Taru , Laine Saara , Saarenhovi Maria , Kallio Petri , Laitinen Kirsi , Houttu Noora , Vähä-Ypyä Henri , Sievänen Harri , Löyttyniemi Eliisa , Vasankari Tommi , Knuuti Juhani , Kalliokoski Kari K. , Heinonen Ilkka H. A.
Published: January 2024

Evidence on the long-term effects of reducing sedentary behaviour (SB) on blood pressure (BP) is scarce. Therefore, we performed a sub-analysis of the BP effects of a six-month intervention that aimed at reducing SB by 1 h/day and replacing it with non-exercise activities. Sixty-four physically inactive and sedentary adults with metabolic syndrome (58% female, 58 [SD 7] years, BP 143/88 [16/9] mmHg, SB 10 [1] h/day) were randomised into intervention (INT, n = 33) and control (CON, n = 31) groups. Resting BP and BP at each stage during and after a graded maximal bicycle ergometer test were measured before and after the intervention. SB, standing, moderate-to-vigorous physical activity (MVPA), and light physical activity (LPA) were measured in six-second intervals at baseline and during the whole six-month intervention using hip-worn accelerometers. The analyses were adjusted for BP medication status. The intervention resulted in a 40 min/day reduction in SB and concomitant 20 min/day increase in MVPA. Resting systolic BP was lower in the CON group before and after the intervention. No group x time interactions were observed in resting BP or BP during exercise at submaximal or maximal intensities, or during recovery. The changes in LPA and MVPA were inversely correlated with the changes in BP during light-to-moderate intensity exercise. An intervention that resulted in a 40 min/day reduction in SB for six months was not sufficient at influencing BP at rest, during or after exercise in adults with metabolic syndrome. However, successfully increasing LPA or MVPA might lower BP during light-to-moderate-intensity activities.
Sub-cycle multidimensional spectroscopy of strongly correlated materials
Authors: Valmispild V. N. , Gorelov E. , Eckstein M. , Lichtenstein A. I. , Aoki H. , Katsnelson M. I. , Ivanov M. Yu. , Smirnova O.
Published: January 2024

Strongly correlated solids are complex and fascinating quantum systems, where new electronic states continue to emerge, especially when interaction with light triggers interplay between them. In this interplay, a sub-laser-cycle electronic response is particularly attractive as a tool for the ultrafast manipulation of matter at the petahertz scale. Here we introduce a new type of nonlinear multidimensional spectroscopy, which allows us to unravel charge and energy flows in strongly correlated systems interacting with few-cycle infrared pulses and the complex interplay between different correlated states evolving on the sub-femtosecond timescale. We demonstrate that the sub-cycle spectroscopy of a single-particle electronic response is extremely sensitive to correlated many-body dynamics and provides direct access to many-body response functions. For the two-dimensional Hubbard model under the influence of ultrashort, intense electric-field transients, we resolve the sub-femtosecond pathways of charge and energy flows between localized and delocalized many-body states and the creation of a highly correlated state surviving after the end of the laser pulse. Our findings open the way towards a regime of imaging and manipulating strongly correlated materials at optical rates, beyond the multicycle approach employed in Floquet engineering, with the sub-cycle response being a key tool for accessing many-body phenomena.
Testing quantum electrodynamics in extreme fields using helium-like uranium
Authors: Loetzsch R. , Beyer H. F. , Duval L. , Spillmann U. , Banaś D. , Dergham P. , Kröger F. M. , Glorius J. , Grisenti R. E. , Guerra M. , Gumberidze A. , Heß R. , Hillenbrand P.-M. , Indelicato P. , Jagodzinski P. , Lamour E. , Lorentz B. , Litvinov S. , Litvinov Yu. A. , Machado J. , Paul N. , Paulus G. G. , Petridis N. , Santos J. P. , Scheidel M. , Sidhu R. S. , Steck M. , Steydli S. , Szary K. , Trotsenko S. , Uschmann I. , Weber G. , Stöhlker Th. , Trassinelli M.
Published: January 2024

Quantum electrodynamics (QED), the quantum field theory that describes the interaction between light and matter, is commonly regarded as the best-tested quantum theory in modern physics. However, this claim is mostly based on extremely precise studies performed in the domain of relatively low field strengths and light atoms and ions1–6. In the realm of very strong electromagnetic fields such as in the heaviest highly charged ions (with nuclear charge Z ≫ 1), QED calculations enter a qualitatively different, non-perturbative regime. Yet, the corresponding experimental studies are very challenging, and theoretical predictions are only partially tested. Here we present an experiment sensitive to higher-order QED effects and electron–electron interactions in the high-Z regime. This is achieved by using a multi-reference method based on Doppler-tuned X-ray emission from stored relativistic uranium ions with different charge states. The energy of the 1s1/22p3/2 J = 2 → 1s1/22s1/2 J = 1 intrashell transition in the heaviest two-electron ion (U90+) is obtained with an accuracy of 37 ppm. Furthermore, a comparison of uranium ions with different numbers of bound electrons enables us to disentangle and to test separately the one-electron higher-order QED effects and the bound electron–electron interaction terms without the uncertainty related to the nuclear radius. Moreover, our experimental result can discriminate between several state-of-the-art theoretical approaches and provides an important benchmark for calculations in the strong-field domain.