bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients
Authors: Affeldt Patrick , Koehler Felix Carlo , Brensing Karl August , Gies Martin , Platen Eva , Adam Vivien , Butt Linus , Grundmann Franziska , Heger Eva , Hinrichs Steffen , Kalisch Nils , Oehm Simon , Steger Gertrud , Wirtz Maike , Benzing Thomas , Stippel Dirk , Klein Florian , Kurschat Christine , Müller Roman-Ulrich , Di Cristanziano Veronica
Published: November 2022

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed. In the present study, the immune response to either a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients. SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.1 were quantified. After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate against BA.1 was significant lower. Concerning KTX recipients, humoral and cellular immune responses after a third vaccination were still highly impaired. This calls for modified omicron-targeting vaccines.
Four Waves of the COVID-19 Pandemic: Comparison of Clinical and Pregnancy Outcomes
Authors: Mihajlovic Sladjana , Nikolic Dejan , Santric-Milicevic Milena , Milicic Biljana , Rovcanin Marija , Acimovic Andjela , Lackovic Milan
Published: November 2022

During the last two and a half years, clinical manifestations, disease severity, and pregnancy outcomes have differed among pregnant patients with SARS-CoV-2 infection. These changes were preceded by the presence of new variants of SARS-CoV-2, known in the literature as variants of concern. The aim of this study is to describe the differences between maternal clinical characteristics and perinatal outcomes among pregnant women with COVID-19 during four waves of the COVID-19 epidemic in Serbia. This retrospective study included a series of 192 pregnant patients who were hospitalized due to the severity of their clinical status of SARS-CoV-2 infection. During four outbreaks of COVID-19 infection in Serbia, we compared and analyzed three sets of variables, including signs, symptoms, and characteristics of COVID-19 infection, clinical endpoints, and maternal and newborn parameters. During the dominance of the Delta variant, the duration of hospitalization was the longest (10.67 ± 1.42 days), the frequency of stillbirths was the highest (17.4%), as well as the frequency of progression of COVID infection (28.9%) and the requirement for non-invasive oxygen support (37%). The dominance of the Delta variant was associated with the highest number of prescribed antibiotics (2.35 ± 0.28), the most common presence of nosocomial infections (21.7%), and the highest frequency of corticosteroid therapy use (34.8%). The observed differences during the dominance of four variants of concern are potential pathways for risk stratification and the establishment of timely and proper treatments for pregnant patients. Early identification of the Delta variant, and possibly some new variants with similar features in the future, should be a priority and, perhaps, even an opportunity to introduce more accurate and predictive clinical algorithms for pregnant patients.
SARS CoV-2 Infection among Health Care Workers from Different Health Care Facilities in Western Norway: A Prospective, Cross-Sectional Study
Authors: Kittang Bård Reiakvam , Blomberg Bjørn , Sævik Marianne , Olofsson Jan Stefan ,   Bergen COVID-19 Research Group, Langeland Nina , Cox Rebecca Jane
Published: November 2022

Background: Comparative data on COVID-19 among health care workers (HCWs) in different health care settings are scarce. This study investigated the rates of previous COVID-19 among HCWs in nursing homes, hospitals and a municipal emergency room (ER). Methods: We prospectively included 747 HCWs: 313 from nursing homes, 394 from hospitals and 40 from the ER. The diagnosis of COVID-19 was based on serological evidence of SARS-CoV-2 antibody positivity and self-reported RT-PCR positivity prior to inclusion. Information regarding age, sex and exposure to SARS-CoV-2 infection was collected. Results: A total of 4% (11/313) of nursing home HCWs and 6% (28/434) of HCWs in hospitals/the ER tested positive by serology and/or RT-PCR (p = 0.095). Fewer HCWs in nursing homes had occupational exposure to SARS-CoV-2 compared to those in hospitals/the ER (16% vs. 48%, p < 0, 001), but nursing homes had a higher proportion of HCWs with occupational exposure using partial/no PPE (56% vs. 19%, p < 0.001). Nevertheless, no significant differences in the risk for COVID-19 were found in relation to the rate of occupational exposure (p = 0.755) or use of inadequate PPE (p = 0.631). Conclusions: Despite a small sample size, the risk for COVID-19 among HCWs did not appear to be related to the type of health care facility, rates of occupational exposure or use of PPE.
Gene Editing Technologies to Target HBV cccDNA
Authors: Martinez Maria Guadalupe , Smekalova Elena , Combe Emmanuel , Gregoire Francine , Zoulim Fabien , Testoni Barbara
Published: November 2022

Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma. Current licensed therapies against HBV efficiently suppress viral replication; however, they do not have significant effects on the intrahepatic covalently closed circular DNA (cccDNA) of the viral minichromosome responsible for viral persistence. Thus, life-long treatment is required to avoid viral rebound. There is a significant need for novel therapies that can reduce, silence or eradicate cccDNA, thus preventing HBV reemergence after treatment withdrawal. In this review, we discuss the latest developments and applications of gene editing and related approaches for directly targeting HBV DNA and, more specifically, cccDNA in infected hepatocytes.
Effect of Hot Water Bottles on Body Temperature during Magnetic Resonance Imaging in Dogs under General Anesthesia: A Retrospective Study
Authors: Shimizu Yuki , Kanda Teppei , Kutara Kenji , Ohnishi Akihiro , Saeki Kaori , Miyabe Masahiro , Asanuma Taketoshi , Ishioka Katsumi
Published: November 2022

Prevention of hypothermia induced by anesthesia and enhanced by low environmental temperatures is difficult in magnetic resonance imaging (MRI) examinations in dogs as forced warming devices, including magnetic materials, are not acceptable for use in the MRI room. A hot water bottle (HWB) can be carried into an MRI examination room and can contribute to the prevention or attenuation of hypothermia. Here, we retrospectively investigated the effects of HWB on body temperature during MRI examinations in dogs under general anesthesia (GA). From anesthesia records of the Veterinary Medical Teaching Hospital, Okayama University of Science, validated data of 100 dogs that underwent an MRI examination under GA were obtained and divided into the following two groups: one group received HWB, while the other did not. Decrease in rectal temperature 15 min after intubation was significantly smaller in the group using HWB than in the group without HWB. In conclusion, the use of hot water bottles might be one of the methods to attenuate hypothermia in the early period but should not be expected for complete prevention of hypothermia, and it was not recommendable necessarily for body temperature management during MRI examinations in dogs under general anesthesia.
Differences in the microRNAs Levels of Raw Milk from Dairy Cattle Raised under Extensive or Intensive Production Systems
Authors: Abou el qassim Loubna , Alonso Jaime , Zhao Ke , Le Guillou Sandrine , Diez Jorge , Vicente Fernando , Fernández-Sanjurjo Manuel , Iglesias-Gutiérrez Eduardo , Guan Leluo , Royo Luis J.
Published: November 2022

Studying microRNA (miRNAs) in certain agri-food products is attractive because (1) they have potential as biomarkers that may allow traceability and authentication of such products; and (2) they may reveal insights into the products’ functional potential. The present study evaluated differences in miRNAs levels in fat and cellular fractions of tank milk collected from commercial farms which employ extensive or intensive dairy production systems. We first sequenced miRNAs in three milk samples from each production system, and then validated miRNAs whose levels in the cellular and fat fraction differed significantly between the two production systems. To accomplish this, we used quantitative PCR with both fractions of tank milk samples from another 20 commercial farms. Differences in miRNAs were identified in fat fractions: overall levels of miRNAs, and, specifically, the levels of bta-mir-215, were higher in intensive systems than in extensive systems. Bovine mRNA targets for bta-miR-215 and their pathway analysis were performed. While the causes of these miRNAs differences remain to be elucidated, our results suggest that the type of production system could affect miRNAs levels and potential functionality of agri-food products of animal origin.
An Analytical Framework for Investigating Trade-Offs between Reservoir Power Generation and Flood Risk
Authors: Zhang Lin , Lund Jay R. , Ding Wei , Zhang Xiaoli , Jin Sifan , Wang Guoli , Peng Yong
Published: November 2022

Converting floodwater into power without increasing flood risk is critical for energy-stressed regions. Over the past decades, numerous methods have been proposed to solve this problem. However, few studies have investigated the theoretical explanation of the trade-offs between power generation and flood risk. This study establishes an analytical framework to derive optimal hedging rules (OHR) and explains the economic insights into flood risk reduction and power generation improvement. A two-stage model based on the concept of dynamic control of carryover storage (DCCS) was developed as part of the framework, considering forecast uncertainty and risk tolerance. The results illustrated that hedging and trade-offs between power generation and flood risk during DCCS only occurs when the forecasted inflow and forecast uncertainty are within certain ranges, beyond which there is no hedging and trade-offs analysis; either power generation or flood risk becomes the dominant objective. The OHR was divided into three cases under different levels of forecast uncertainty and risk tolerance. Compared to forecast uncertainty, downstream risk tolerance plays a more important role in determining which case of the OHR is adopted in real-world operations. The analysis revealed what and how intense trade-offs are between power generation and flood risk under different scenarios of forecasted inflow, forecast uncertainty, and risk tolerance. The framework serves as a guideline for less abundant water resources or energy-stressed areas of operational policy. Nierji Reservoir (located in northeast China) was taken as a case study to illustrate the analysis, and the application results showed that OHR increases the average annual power generation by 4.09% without extra flood risk compared to current operation rules.
Sedimentation Rates: Anthropogenic Impacts and Environmental Changes in Transitional Water Systems
Authors: Sfriso Adriano , Buosi Alessandro , Juhmani Abdul-Salam , Tomio Yari , Mistri Michele , Munari Cristina , Sfriso Andrea Augusto
Published: November 2022

The trophic evolution of the Venice lagoon was analyzed by studying the particulate collected monthly with sedimentation traps in many areas of the Venice lagoon since 1989, and at Goro in 2018–2019. Sedimentation rates were strongly related to the presence of macrophytes, which reduced sediment resuspension, and to anthropogenic pressures, such as clam harvesting and naval-boat traffic, that triggered sediment resuspension and loss. The highest mean annual sedimentation rates (from 2000 to over 4000 g DWT m−2 day−1) have been recorded in many areas of the Venice lagoon between 1998–1999 to 2001–2002, during the intense fishing activities of the clam Ruditapes philippinarum. High values (daily peaks up to 5224 g DWT m−2 day−1) were also recorded in areas affected by marine and/or recreational traffic, due to the high wave motion. In contrast, the presence of high biomasses of macroalgae, or seagrasses, reduced significantly sediment resuspension and settlement, with mean annual sedimentation rates ranging between 40 and 140 g DWT m−2 day−1 and minimum values of 6–10 g DWT m−2 day−1. High sedimentation rates were strongly related to a lower sediment grain-size, with loss of the fine fraction and dispersion of nutrients and pollutants in the whole lagoon.
Comparison of the Microbial Communities Affected by Different Environmental Factors in a Polluted River
Authors: Ouyang Liao , Liu Xinyue , Chen Huirong , Yang Xuewei , Li Shaofeng , Li Shuangfei
Published: November 2022

Understanding how bacterial communities adapt to different environmental factors provides a scientific basis for developing and utilizing microbial resources in rivers. This study investigated the changes in the microbial communities of water and mud samples from two sites of an urban river (GH: Gonghe Village and YC: Yanchuan). Analysis of the water samples showed that site GH had higher concentrations of ammonium, total nitrogen, Mn, and Ni than site YC. High-throughput sequencing was used to analyze the community composition of the samples. The results showed that the dominant phyla were Proteobacteria, Bacteroidete, Actinobacteria, and Chloroflexi. The alpha diversity of the microbial community in the mud samples was higher than in the water samples. Moreover, the relative abundance of the dominant genus varied a lot between the samples, with the highest relative abundance of Arcobacter and Vibrio found in the water samples at site GH in January and October, respectively. The correlation analysis showed that pH, TN, manganese, and fluoride were the main environmental factors that affected the composition and structure of the microbial communities. The phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis showed that species associated with nitrogen metabolism differed between the sampling sites. In addition, potential pathogens, such as Vibrio and Arcobacter, which may pose potential risks to the environment and human health, were found in the samples.
Advancement of a Liquid Scintillation Counter and Semiconductor Alpha Spectroscopy Detector to Estimate the Radon Concentration in Groundwater
Authors: Mamun Al , Alazmi Amira Salman
Published: November 2022

Radon is one of the most natural forms of radiation for human exposure. However, high-accuracy measurement of natural radon in water samples is very challenging due to the background correction, data acquisition, and sampling time. Liquid scintillation counter (LSC) and semiconductor alpha spectroscopy detectors are the most commonly used methods of determining radon concentration in water. The present study utilizes both methods to estimate radon in groundwater collected from various locations in the northeast region of Saudi Arabia. The estimated radon concentrations using Hidex 300SL are compared with a Durridge RAD7 detector to evaluate each apparatus’s abilities, advantages, and disadvantages. Both methods show radon concentrations between 0.1 and 3.20 Bq/L with an average of 0.96 Bq/L, with a standard deviation of 0.82 Bq/L. The estimated values are found to be in the safe limit recommended by the USEPA and EAEC and are far below the safe level recommended by UNSCEAR and the WHO. Comparing the estimated radon concentration using the two methods shows that although the two devices have many advantages and disadvantages based on the two different techniques, the experimental results are almost the same with experimental error.
Bridging the Data Gap between the GRACE Missions and Assessment of Groundwater Storage Variations for Telangana State, India
Authors: Kumar Kuruva Satish , Sridhar Venkataramana , Varaprasad Bellamkonda Jaya Sankar , Chinnapa Reddy Konudula
Published: November 2022

Because of changing climatic conditions, uneven distribution of rainfall occurs throughout India. As a result, dependence on groundwater for irrigation has increased tremendously for industrial and domestic purposes. In India approximately 89% of agricultural demands are met through groundwater. Due to increases in population, demand for groundwater and lack of effective utilization have resulted in rapid depletion of groundwater in most parts of the country. Therefore, quantifying groundwater resources is a serious concern in populated states of India, because it is now difficult to supply enough water to every citizen, and will remain so in the future. Because of difficulties in accessing observation data, researchers have begun to depend on satellite-based remote sensing information to deal with groundwater variations. The present study deals with filling the data gap between Gravity Recovery And Climate Experiment (GRACE) and GRACE Follow On (GRACE FO) missions using multilayer perceptron’s (MLPs) during 2017–2018 to obtain a continuous terrestrial water storage anomaly (TWSA) series from 2003 to 2020 for Telangana state, India. The MLP model performed well in predicting the TWSA, with a correlation coefficient of r = 0.96 between modeled TWSA and GRACE TWSA during the test period. Telangana state observed negative TWSAs (annual) in the years 2003, 2004, 2005, 2009, 2012, 2015, and 2016–19. This TWSA series (2003–2020) was then used to evaluate regional groundwater storage anomalies (GWSAs) in Telangana state, which is considered to be one of the water stress regions in India. The TWSAs were converted to GWSAs using Global Land Data Assimilation System (GLDAS) parameters. The Telangana state experienced decreasing GWSA in the years 2005, 2009, and 2012, and from 2015 to 2019, leading to severe droughts. Groundwater well measurements were obtained from the Central Groundwater Board (CGWB) and converted to GWSA at a seasonal scale. The GWSAs obtained from GRACE (GWSAGRACE) were converted to seasonal values and compared with GWSAs obtained from observation well data (GWSAobs). The performance metrics of r = 0.74, RMSE = 5.3, and NSE = 0.62 were obtained between (GWSAGRACE) and (GWSAobs), representing a good correlation among them. Over the past decade, Telangana state has significantly relied on groundwater resources for irrigation, domestic, and industrial purposes. As a result, evaluating groundwater storage variations at a regional scale may help policy makers and water resource researchers in the sustainable utilization and management of groundwater resources.
The Influence of River Morphology on the Remote Sensing Based Discharge Estimation: Implications for Satellite Virtual Gauge Establishment
Authors: Shi Zhuolin , Chen Qianqian , Huang Chang
Published: November 2022

Monitoring of river discharge is a key process for water resources management, soil and water conservation, climate change, water cycling, flood or drought warning, agriculture and transportation, especially for the sustainable development of rivers and their surrounding ecological environment. Continuous and comprehensive discharge monitoring was usually impossible before, due to sparse gauges and gauge deactivation. Satellite remote sensing provides an advanced approach for estimating and monitoring river discharge at regional or even global scales. River morphology is generally considered to be a direct factor that affects the accuracy of remote sensing estimation, but the specific indicators and the extent to which it affects the estimation accuracy have not yet been explored, especially for medium to small rivers (width < 100 m). In this paper, six sites with hydrological gauges in the upper Heihe River Basin (HRB) of northwestern China and the Murray Darling Basin (MDB) of southeastern Australia were selected as the study cases. River discharge was estimated from Landsat imagery using the C/M method accordingly. River gradient, sinuosity, and width were obtained from Digital Elevation Model data for each site. Global Surface Water Dataset (GSWD) was also employed for indicating the dynamic status of river morphology. A series of methods were applied to analyze the influence of river morphology on estimation accuracy qualitatively and quantitatively, based on which we established inference about the theory of selecting satellite virtual gauges (SVGs). The results confirm the feasibility of the C/M method for discharge estimation, with the accuracy affected by multiple river morphological indicators. Among them, river width was found to be the most significant one. Moreover, water occurrence and water extent extracted from GSWD also have impact on the discharge estimation accuracy. Another independent river section in MDB was set as an example to demonstrate the reasonability of the established theory. It is anticipated that this study would promote the application of remote sensing for discharge estimation by providing practical guidance for establishing appropriate SVGs.
Challenges of Comparing Marine Microbiome Community Composition Data Provided by Different Commercial Laboratories and Classification Databases
Authors: Mioduchowska Monika , Iglikowska Anna , Jastrzębski Jan P. , Kaczorowska Anna-Karina , Kotlarska Ewa , Trzebny Artur , Weydmann-Zwolicka Agata
Published: November 2022

In the high-throughput sequencing (HTS) era, a metabarcoding technique based on the bacterial V3–V4 hypervariable region of 16S rRNA analysis requires sophisticated bioinformatics pipelines and validated methods that allow researchers to compare their data with confidence. Many commercial laboratories conduct extensive HTS analyses; however, there is no available information on whether the results generated by these vendors are consistent. In our study, we compared the sequencing data obtained for the same marine microbiome community sample generated by three commercial laboratories. Additionally, as a sequencing control to determine differences between commercial laboratories and two 16S rRNA databases, we also performed a “mock community” analysis of a defined number of microbial species. We also assessed the impact of the choice of two commonly used 16S rRNA databases, i.e., Greengenes and SILVA, on downstream data analysis, including taxonomic classification assignment. We demonstrated that the final results depend on the choice of the laboratory conducting the HTS and the reference database of ribosomal sequences. Our findings showed that the number of produced ASVs (amplicon sequence variants) ranged from 137 to 564. Different putative bacterial endosymbionts could be identified, and these differences correspond to the applied 16S rRNA database. The results presented might be of particular interest to researchers who plan to perform microbiome community analysis using the 16S rRNA marker gene, including the identification of putative bacterial endosymbionts, and serve as a guide for choosing the optimum pipeline to obtain the most accurate and reproducible data.
Different Adsorption Behaviors and Mechanisms of Anionic Azo Dyes on Polydopamine–Polyethyleneimine Modified Thermoplastic Polyurethane Nanofiber Membranes
Authors: Sun Jiaoxia , Zhou Yao , Jiang Xueting , Fan Jianxin
Published: November 2022

Considering the notable mechanical properties of thermoplastic polyurethane (TPU), polydopamine–polyethyleneimine (PEI) -modified TPU nanofiber membranes (PDA/PEI-TPU NFMs) have been developed successfully for removal of anionic azo dyes. The adsorption capacity of PDA/PEI-TPU NFMs was evaluated using three anionic dyes: congo red (CR), sunset yellow (SY), and methyl orange (MO). Interestingly, it exhibited different adsorption behaviors and mechanisms of CR on PDA/PEI-TPU NFMs compared with SY and MO. With the decrease in pH, leading to more positive charges on the PDA/PEI-TPU NFMs, the adsorption capacity of SY and MO increased, indicating electrostatic interaction as a main mechanism for SY and MO adsorption. However, wide pH range adaptability and superior adsorption have been observed during the CR adsorption process compared to SY and MO, suggesting a synergistic effect of hydrogen bonding and electrostatic interaction, likely as a critical factor. The adsorption kinetics revealed that chemical interactions predominate in the CR adsorption process, and multiple stages control the adsorption process at the same time. According to the Langmuir model, the maximum adsorption capacity of CR, SY and MO were reached 263, 17 and 23 mg/g, respectively. After six iterations of adsorption–desorption, the adsorption performance of the PDA/PEI-TPU NFMs did not decrease significantly, which indicated that the PDA/PEI-TPU NFMs have a potential application for the removal of CR molecules by adsorption from wastewater.
Flood Modeling in a Coastal Town in Northern Colombia: Comparing MODCEL vs. IBER
Authors: Pérez-Montiel Jhonny I. , Cardenas-Mercado Leyner , Nardini Andrea Gianni Cristoforo
Published: November 2022

In Riohacha the La Niña, phenomenon generates intense rains with consequent serious flooding. To address this reality, MODCEL, a conceptual cell-based model, had been applied and calibrated in a previous project. In this research, we compare MODCEL with IBER, a well-known, physically based 2D hydraulic model. The purpose is twofold: (i) to illustrate how system schematization can be carried out in the two modeling frameworks, which is not a trivial task and implies several choices and assumptions; (ii) to point out the strengths and weaknesses of these two models in a comparative fashion. Here, IBER has been calibrated and validated with the same data used for MODCEL. MODCEL performs slightly better, both in calibration and validation possibly because of the low resolution of the topographic information, an essential element for IBER. Furthermore, in IBER it is not possible to represent adequately all the different hydraulic works spread across the town. MODCEL, in turn, is not easy to apply because it requires a deep insight into the actual behavior of the physical system and time-consuming schematization attempts where a deep experience is needed; furthermore, it is by far less user-friendly than IBER. In any case, the two models capture sufficiently well the behavior of urban flooding and its changes according to hypothetical interventions.
Assessing Coastal Flood Susceptibility in East Java, Indonesia: Comparison of Statistical Bivariate and Machine Learning Techniques
Authors: Hidayah Entin , Indarto  , Lee Wei-Koon , Halik Gusfan , Pradhan Biswajeet
Published: November 2022

Floods in coastal areas occur yearly in Indonesia, resulting in socio-economic losses. The availability of flood susceptibility maps is essential for flood mitigation. This study aimed to explore four different types of models, namely, frequency ratio (FR), weight of evidence (WofE), random forest (RF), and multi-layer perceptron (MLP), for coastal flood susceptibility assessment in Pasuruan and Probolinggo in the East Java region. Factors were selected based on multi-collinearity and the information gain ratio to build flood susceptibility maps in small watersheds. The comprehensive exploration result showed that seven of the eleven factors, namely, elevation, geology, soil type, land use, rainfall, RD, and TWI, influenced the coastal flood susceptibility. The MLP outperformed the other three models, with an accuracy of 0.977. Assessing flood susceptibility with those four methods can guide flood mitigation management.
Understanding Hydrological Processes under Land Use Land Cover Change in the Upper Genale River Basin, Ethiopia
Authors: Shigute Mehari , Alamirew Tena , Abebe Adane , Ndehedehe Christopher E. , Kassahun Habtamu Tilahun
Published: November 2022

The expansion of cultivated land in place of natural vegetation has a substantial influence on hydrologic characteristics of a watershed. However, due to basin characteristics and the nature and intensity of landscape modification, the response varies across basins. This study aims to evaluate the performance of a soil and water assessment tool (SWAT) model and its applicability in assessing the effects of land use land cover (LULC) changes on the hydrological processes of the upper Genale River basin. The results of satellite change detection over the past 30 years (between 1986 and 2016) revealed that the landscape of the basin has changed considerably. They showed that settlement, cultivated, and bare land areas had increased from 0.16% to 0.28%, 24.4% to 47.1%, and 0.16% to 0.62%, respectively. On the contrary, land cover units such as forest, shrubland, and grassland reduced from 29.6% to 13.5%, 23.9% to 19.5%, and 21.8% to 18.9%, respectively. Based on monthly measured flow data, the model was calibrated and validated in SWAT-CUP using the sequential uncertainty fitting (SUFI-2) algorithm. The result showed that the model performed well with coefficient of determination (R2) ≥ 0.74, Nash–Sutcliffe efficiency (NSE) ≥ 0.72, and percent bias (PBIAS) between −5% and 5% for the calibration and validation periods. The hydrological responses of LULC change for the 1986, 2001, and 2016 models showed that the average annual runoff increased by 13.7% and 7.9% and groundwater flow decreased by 2.85% and 2.1% between 1986 and 2001 and 2001 and 2016, respectively. Similarly, the total water yields increased from 324.42 mm to 339.63 mm and from 339.63 mm to 347.32 mm between 1986 and 2001 and 2001 and 2016, respectively. The change in hydrological processes, mainly the rise in runoff and total water yield as well as the reduction in lateral and groundwater flow in the watershed, resulted from LULC changes. This change has broader implications for the planning and management of the land use and water resource development.
A organização enunciativa do discurso religioso de representantes cristãos sobre o aborto em canais do Youtube
Authors: Saraiva Paes Russi Glicéria Márcia , Santos de Souza Melo Mônica
Published: November 2022

Nesse artigo nos propomos a analisar, por meio da Teoria Semiolinguística de Patrick Charaudeau, o comportamento enunciativo presente em dois vídeos do Youtube, nos quais dois representantes religiosos, um da Igreja Católica Apostólica Romana e outro da igreja neopentecostal Assembleia de Deus Vítória em Cristo do Brasil, utilizam dessa plataforma midiática para se posicionarem contrários à prática do aborto e à legalização deste, depois de um caso específico de abortamento, autorizado pela justiça e realizado em Recife no dia 16/08/2020 em uma menina de 10 anos, vítima de estupro. Após a transcrição, descrição e análise dos dados e observadas as categorias relativas ao modo de organização enunciativo, previstas em Charaudeau (2019), foi possível identificar algumas estratégias discursivas utilizadas por eles para construção de um discurso patêmico que proporcione a captação de um maior número de fiéis.
desconstrução da visão heteronormativa no ensino de português língua estrangeira a partir da análise de duas peças publicitárias
Authors: Vieira Letícia
Published: November 2022

Esta pesquisa busca analisar e repensar a visão estereotipada da heteronormatividade no Brasil, a qual se faz presente em nossa sociedade e, consequentemente, a representação deste modelo hegemônico de configuração de famílias/casais encontra-se com frequência nos materiais didáticos de Português Língua Estrangeira (PLE). Percebe-se que as relações afetivas aparecem nos livros, em sua maioria, representadas por uma mulher e um homem, fazendo com que essa ideia seja disseminada como “configuração padrão”, marginalizando, assim, as uniões homoafetivas e as mais diversas configurações familiares de nosso tempo. Todavia, apesar de termos que levar em consideração que alguns livros não são tão atuais, é necessário que essa representação seja remoldada, uma vez que vivemos um momento de mudança na nossa sociedade e que já não nos deparamos apenas com a constituição heterossexual de família/casal. Dessa forma, o objetivo deste trabalho é refletir de que modo a visão heteronormativa pode ser desconstruída dentro da sala de aula de PLE, a fim de apresentar para os alunos estrangeiros diferentes formas de relação entre os indivíduos e, desse modo, construir uma ideia de inexistência de um padrão. Para tanto, selecionamos um corpus constituído de duas peças publicitárias que abordam a temática de modo desconstrucionista, e, a partir de sua análise, são discutidas estratégias didáticas que possibilitem a abordagem das relações afetivas tanto homossexuais quanto heterossexuais. Esta investigação se deu à luz das contribuições da Teoria das Representações Sociais e da Teoria Queer, e considerou os conceitos de Sexo e Gênero, Heteronormatividade, Cultura e Interculturalidade.
Ação do canabidiol em doenças neurológicas
Authors: Veronez de Lima Bruno , Neves Afonso Carlos
Published: November 2022

Introdução. O canabidiol, fármaco derivado da Cannabis Sativa, tem sido usado em várias condições médicas, com resultados que têm sido discutidos. Aparentemente seus efeitos parecem melhores para quadros neurológicos, psiquiátricos, e quadros que envolvam dor importante, como em moléstias oncológicas. Método. Revisão de literatura sobre o uso do canabidiol e a sua relação com doenças neurológicas em geral. Foi consultada a base de dados PubMed. Além disso, foram lançadas as palavras "canabidiol", "neurological diseases”, “CBD” e “neurological disorder” no menu de pesquisa dessa plataforma. Resultados. Dos trabalhos encontrados, foram selecionados 12 artigos de revisão que atendiam aos critérios de inclusão. Estes foram escolhidos porque evidenciam a ação do canabidiol em doenças neurológicas de forma abrangente e clara, não associando a outras patologias que não fazem parte do escopo deste trabalho. Conclusão. Os artigos indicam que pode haver alguma melhora sintomatológica, mas os artigos escolhidos apontam a necessidade de mais pesquisas.
Common Challenges Postgraduate Students and Early-Career Academics face when Engaging with the Scholarly Literature
Authors: Daniel Ben
Published: November 2022

This article presents nine common challenges postgraduate students and early career academics face when engaging with academic literature. Data was collected from a sample of sixty-two postgraduate and early career academics who participated in a series of workshops on research methodology at a research-intensive university in New Zealand. Participants were invited to answer open-ended questions online about the purpose of undertaking a literature review and the challenges associated with the process. Findings revealed that participants held fragmented views about the purpose of engaging with the literature review, which contributed to the difficulties they faced in effectively undertaking the literature review. The challenges participants reported when undertaking literature reviews: difficulties in choosing a practical approach to reviewing the literature, inability to design an efficient search strategy to locate materials for review, problems locating relevant literature, an inability to determine the appropriate scope of a review, issues in choosing relevant materials and managing the growing volume of published work, problems in effectively synthesising and critiquing the literature, inability to organise and write clear reports, and lack of indicators for assessing the quality of written literature reports. The research presents a wide range of strategies students, and early career academics can use to mitigate these challenges. Teachers of research methods can also use these strategies to support students develop the necessary skills and knowledge to tackle the challenges of engaging with the literature.
An Improved Hungarian Algorithm for a Special Case of Unbalanced Assignment Problems
Authors: Chowdhury Mohammad Shyfur Rahman
Published: November 2022

The current Hungarian approach to solving unbalanced assignment issues is based on the notion that some tasks should be delegated to fictitious or covert components, and those studies should be left unperformed. In real-world scenarios, it may be desirable to carry out all of the tasks on fundamental details. To do this, multiple tasks may be distributed to a single machine. The current research's enhanced Hungarian method for addressing unbalanced assignment challenges results in the ideal work assignment policy. An example using numbers shows how well the suggested strategy works and how effective it is. The acquired result is then likened to other current approaches to demonstrate our algorithm's superiority.
Penentuan Tipe Akuifer Daerah Bulontala Kabupaten Bone Bolango Menggunakan Metode Geolistrik
Authors: Dai Elan , Zainuri Ahmad , Akase Noviar
Published: November 2022

Research area Geographically, the location is at 0ᵒ31'0''N - 0ᵒ31'30'' North Latitude 123ᵒ8'0'' - 123ᵒ8'30'' East Longitude with an area of ± 22.02 km. The research location is an andesite lava hill unit. because the type of rock found at that location is andesite igneous rock. The purpose of this study is to determine the type or type of aquifer. The method used is in the form of collecting surface and subsurface geological data. The method used is the geoelectric method with the Schlumberger configuration. The results of the research for geological mapping of the research location have morphology in the form of volcanic plains and hills with an altitude of 200 meters above sea level. The statigraphic sequence at the research site is sorted from easy to leader, old unit in the form of Andesite and easy unit in the form of alluvial. As for the geological structure that plays a role in the study, the dominant direction is from the north to the south.Groundwater at the research site follows the topography of the research location which flows from south to north where the water flows from upstream to downstream, from high to low elevation points. based on the results of geoelectric research and well water data collection that the aquifer at that location is shallow with alluvial material types, sand and andesite igneous rocks.The type of aquifer at the research site obtained from geoelectric research is a free aquifer type (not compressed) and only has 1 boundary layer, namely andesite igneous rock.
Pelatihan Penggunaan Aplikasi Quizlet untuk Pembuatan Soal Matematika Pada Materi Geometri di SMP
Authors: Alfi Yunita  , Zulfitri Aima  , Audra Pramitha Muslim
Published: November 2022

Based on the results of interviews at partner schools, namely SMPN 27 Padang, it can be seen that the learning process carried out by teachers during the COVID-19 Pandemic is a learning process using throught WhatsApp by giving assignments to students. Therefore, the proposer and partners work together in overcoming these problems through the Community Service (PKM) program. This PKM program aims to increase teachers' knowledge about the application of online learning models, so training on the use of the Quizlet Application for Making Mathematics Problems in Geometry Material been given. The method used in achieving these goals is a simulation method and practice using the Quizlet application. The result of this community service is to increase teacher knowledge in using the Quizlet application in the mathematics learning process.
Aprendemos...sobre los fósiles.
Authors: Muñiz Guinea Fernando , Martín García Domingo , Delgado Rodríguez Joaquín María , Romero Baena Antonio , Barba Brioso Cinta
Published: November 2022

Explicación, sobre qué es un fósil, el proceso de fosilización, los tipos de conservación con que podemos encontrarlos (moldes internos, externos e impresiones), la importancia de los fósiles, concepto de fósil guía y como indicadores de extinciones biológicas.
El video se integra en la serie Aprendemos… formada por tres videos didácticos para facilitar recursos de aprendizaje al alumno como refuerzo o previa asistencia a prácticas de asignaturas relacionadas con la geología, en concreto sobre propiedades de los minerales, clasificación de las rocas y sobre fósiles y el proceso de fosilización.

Este vídeo y su serie son útiles para cualquier alumno de secundaria o grado en el que se estudien materiales naturales como fósiles y rocas sedimentarias (Educación, Ingenierías, Ciencia de Materiales…).

Mediante su visualización y manipulación se pueden reconocer los principales criterios de observación y clasificación delos fósiles como restos de organismos del pasado y de su actividad (por ejemplo, huellas). En primer lugar, se ofrece la definición de fósil, seguido de las rocas en las que se pueden reconocer y encontrar. A continuación, se abordan las fases del proceso de fosilización y resultados, es decir, de los diferentes tipos de conservación en los que podemos encontrarlos. Por último, se tratan aspectos de los fósiles como marcadores de extinciones, destacando a los fósiles guías, es decir, restos de organismos característicos de una era geológica particular.
Habitar na pandemia: as influências da arquitetura e do design de interiores nas condições de bem-estar domiciliar das mulheres idosas
Authors: Paula Ana Luiza Delgado de , Braida Frederico , Zambrano Letícia Maria de Araújo
Published: November 2022

A pandemia de Covid-19 modificou as relações dos indivíduos com a moradia e expôs as deficiências da arquitetura residencial brasileira. No Brasil,o número de idosos vem aumentando, sendo a maior parte deles do sexo feminino. A pesquisa objetiva compreender, através da motivação das mulheres idosas em realizar reformas em suas casas durante a pandemia, suas percepções acerca dos elementos arquitetônicos e do design de interiores que são influentes em seu bem-estar.Foi realizada uma pesquisa bibliográfica,seguida por uma coleta de dados empíricos: entrevistas on-line com dez idosas que tiveram suas casas reformadas durante a pandemia, na cidade de Juiz de Fora (MG). Para a análise das entrevistas, lançou-se mão da análise do discurso. Ao final, foi possível perceber três principais motivações para a realização das reformas: mudança na rotina causada pelo distanciamento social, busca por identidade no ambiente construído e busca por melhorias nas condições de execução das AIVDs.
Modificabilidade: qualidade que emerge da negociação do espaço de possibilidades no design de jogos digitais
Authors: Souza Matheus Corrêa de , Silva Tiago Barros Pontes e , Van Amstel Frederick M. C.
Published: November 2022

Este artigo tem como objetivo definir a modificabilidade, a qualidade de projeto que emerge da negociação do espaço de possibilidades entre game designers, jogadores e modders. Para chegar a esse objetivo, a Teoria Histórico-Cultural da Atividade foi adotada como lente teórica e metodológica. A aplicação da metodologia se deu por meio da análise histórica das atividades lúdica, de game design e de modding, identificando a evolução das interações entre essas atividades ao longo da história. Por meio dessa análise, observou-se o caráter de objeto fugidio das possibilidades do espaço lúdico e definiu-se a modificabilidade como um conjunto de decisões tomadas pelos game designers no intuito de exercer controle sobre o seu potencial de modificação, seja para ampliá-lo ou restringi-lo, por meio da influência sobre as ferramentas, comunidade, regras e objeto da atividade lúdica e do modding. Assim, essa dimensão se torna também relevante para outros campos do design no projeto de artefatos interativos. Complementarmente, uma escala qualitativa de modificabilidade foi apresentada como instrumento de análise.
AACSB-ACCREDITATION BENEFITS AS PREDICTOR OF FACULTY ATTITUDE TOWARD THE ACCREDITATION PROCESS: AN EXPLORATORY STUDY
Authors: Mady M. Tawfik , Al-Hussainan Adel , Mady Tarek Tawfik
Published: November 2022

The purpose of the study is to investigate the attitude of faculty members of the College of Business Administration at Kuwait University (CBA-KU) toward the AACSB accreditation system and the way they perceive the benefits of accreditation. The level of association and the causal effect of perceived benefits on shaping faculty attitude are also addressed. A questionnaire was administered to all faculty members at CBA-KU resulting in a final response of 43 observations. While the one-sample t-test and Pearson correlation were used to investigate faculty attitude and perceived benefits and their level of association, Regression analysis was utilized in testing the effect of perceived benefits on faculty attitudes. Findings revealed a relatively high positive attitude toward AACSB accreditation and a significant above-average level of agreement with all addressed benefit statements. Significant positive correlation between benefits and attitudes and a significant effect of academic benefits on faculty attitude were also confirmed. The study is the first AACSB accreditation survey in Kuwait which enriches the understanding of the value of earning the accreditation and highlights some factors that enhance faculty positive attitude toward AACSB accrediting.
DIAGNÓSTICO E TRATAMENTO DE DIABETES GESTACIONAL: UMA REVISÃO INTEGRATIVA
Authors: Maria Martins Petronio Jaira , Costa Souza Kelli , do Nascimento Andrade Feitosa Ankilma , Sousa Gabriel Igor , de Abreu Carolino Rodolfo , Modesto de Brito Luciana
Published: November 2022

INTRODUÇÃO: Nos últimos 20 anos, a epidemia global de diabetes e obesidade atingiu a população de mulheres em idade reprodutiva; paralelamente, houve um aumento na incidência de hiperglicemia durante a gravidez. Esta entidade foi associada a várias complicações obstétricas e perinatais, particularmente a macrossomia fetal, parto traumático e complicações hipertensivas. OBJETIVOS: demonstrar formas de diagnosticar a DM gestacional e as variadas opções terapêuticas. METODOLOGIA: Na presente pesquisa, as bibliotecas utilizadas para busca serão: a Biblioteca Virtual em Saúde (BVS), através da base de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs); a Scientific Eletronic Library Online (ScIELO) e o PubMed. A busca realizar-se-á entre os meses de Fevereiro de 2021 a Julho de 2022, utilizando-se as seguintes palavras-chave: Diabetes; Diabetes Gestacional; Diagnóstico; Gravidez; Tratamento. A busca limitar-se-á a estudos em seres humanos, redigidos em inglês e português e que tenham sido publicados nos últimos 10 anos. RESULTADOS E DISCUSSÕES: São apresentadas informações a respeito dos 7 artigos contidos na discussão desta revisão de literatura. Esta patologia está associada a várias complicações obstétricas e perinatais, especialmente complicações de fetos macrossômicos, parto traumático e hipertensão. As complicações podem ser prevenidas por meio de estratégias de intervenção, incluindo as não farmacológico, como mudanças no estilo de vida, dieta, exercícios e farmacológicas como usam de insulina e / ou hipoglicemiantes orais CONCLUSÃO: O estudo permitiu conhecer os diagnósticos e tratamentos para diabetes mellitus gestacional, revelando que as informações sobre a doença ainda são escassas, tanto entre as gestantes quanto para os profissionais de saúde.

PALAVRAS - CHAVE: Diabetes; Diabetes Gestacional; Diagnóstico; Gravidez; Tratamento.
Sobre economias transformadoras
Authors: Parente Cristina
Published: November 2022

A conferência realizada em agosto de 2018 discutiu as diferentes propostas teóricas de resolução dos novos e velhos problemas sociais num contexto de esgotamento do modelo económico e social vigente, caraterizado pelo retrocesso das políticas sociais dos Estados Providência. Apresentaram-se as propostas de continuidade com o modelo vigente a partir das abordagens anglófonas doempreendedorismo social e da inovação social. O foco da discussão foi colocado na perspetiva transformadora da economia solidária, configurada como uma “outra economia”. A reflexão incide sobre o caráter progressista ou reformista das propostas no que diz respeito à solução protagonizada.