bluuebunny/crossref_metadata_2025 huggingface dataset:
An IoT-based handheld environmental and air quality monitoring station
Authors: Aashiq M. N. M. , Kurera W. T. C. C. , Thilekaratne M. G. S. P. , Saja A. M. A. , Rouzin M. R. M. , Neranjan Navod , Yassin Hayti
Published: August 2023

Weather and air quality play an important role in determining environmental pollution. Fluctuation of these parameters not only causes environmental pollution but also causes severe injuries to human health. With the emergence of the Internet of Things (IoT), sensor-based weather devices with easy observation facilities started to develop. In this regard, this study focused on developing an IoT-based portable weather monitoring gadget that can measure weather and air parameters which are more often required in our day-to-day life. The proposed system is capable to measure temperature, pressure, humidity, altitude, PM2.5, PM10 level, VOC, and CO level. It consists of a portable display and a mobile app with a thing speak cloud platform. Further, the system has a Wi-Fi and GSM connection to communicate data. A mobile application was developed to monitor the readings in real-time which are stored in the cloud platform. The developed hardware was carefully calibrated in the national meteorological department to make sure our system is practically usable. Compared to existing models, our prototype is very handholdable, easily installable which does not require trained technicians, and is easily maintainable. Also, it is possible to access the data from anywhere in the world through Wi-Fi connectivity, and possible to make data visualization and analysis. On the other hand, it is very difficult to find a single, portable size, and low-cost device to collect all these parameters together. Nonetheless, our prototype has the potential of connecting with multiple similar devices to create a larger IoT network grid. Overall, our proposed product has a combination of weather and air quality parameters in a portable and handholdable size with low-cost and low power consumption which other devices do not have according to the latest literature.
Determining the location of patients in remote rehabilitation by means of a wireless network
Authors: Tohoiev Oleksii
Published: August 2023

This article discusses the indoor object's location identification method that had been developed to use in medical facilities. Differently from other similar methods, the one reported in this paper requires access to Wi-Fi access points only and, most importantly, it does not require the mobile device to be in hotspot mode. It is proposed to use Wi-Fi access points (routers) with non-standard firmware as measuring equipment to determine the coordinates of the patient's location within the medical institution. Thus, it can be claimed that using of the proposed method will help to achieve acceptable accuracy in real environments at real-time identification mobile devices using simple hardware and software requirements.
Gzhelian (latest Carboniferous) Pseudoacutella partoazari foraminiferal assemblage from the Tabas Block (Central Iran)
Authors: Yarahmadzahi Hamed , Vachard Daniel
Published: August 2023

A foraminiferal assemblage is reported from the Zaladou Formation in the Tabas Block (Shishtu Section), Central Iran. This assemblage comprises 16 species belonging to 14 genera, and encompasses the fusulinids Pseudoacutella partoazari, Grovesella tabasensis, Gr. aff. australis, Gr. sphaerica, Gr. sphaerica var. quadrata, Gr. cf. staffelloides, Schubertina sp., Schubertella sp., and the smaller foraminifers Eotuberitina sp., Lasiodiscus tenuis, Raphconilia cf. minor, R. multihelicis, R. modificata, Tetrataxis cf. parviconica, Globivalvulina ex gr. bulloides, Gl. graeca, Calcivertella heathi, Tansillites sp., Palaeonubecularia? sp., Hemigordiellina sp., Nodosinelloides longa, and N. longissima. The age of this assemblage is considered to be Gzhelian. The assemblage is dominated by the fusulinid Pseudoacutella partoazari with a low total diversity of smaller foraminifers. This assemblage is compared to similar assemblages in other parts of Iran and well as the USA. An evolutionary lineage of Pseudoacutella partoazari is also proposed. It is confirmed that Pseudonovella differs from Pseudoacutella by the periphery rounded-carinate (carinate in Pseudoacutella), pseudochomata less developed, and the type of coiling (Pseudoacutella is truly planispiral involute). Pseudonovella is suggested here as the ancestor of Pseudoacutella. This assemblage bears one unusual attribute, the overwhelming dominance of the fusulinid Pseudoacutella and the relatively low total diversity, compared with similar foraminifera from Alborz, Sanandaj-Sirjan, Sabzevar and central Iran, which present warm and humid conditions during the Late Carboniferous.
Dimensions of Vaccination Attitudes in Nigeria: A Study of the Impacts of COVID-19 Vaccine Risk Perception and Acceptance
Authors: Lawal Abiodun Musbau , Olawa Babatola Dominic , Odoh Ikenna Maximillian , Olawole Ayodeji Olorunfemi , Ajayi Olubukola , Azikiwe Judith Chineye , Ayodele Israel Oluwatosin , Odusina Emmanuel Kolawole , Attah Thomas , Odedokun Ezekiel Adeyemi , Babatunde Stephen Ishola , Oladejo Teslim Alabi , Otoghile Confidence Chioma , Saka Saheed Abiola
Published: August 2023

Nigeria has been affected by the COVID-19 pandemic, and vaccination is a key strategy. However, the country faces vaccination hesitancy, poor risk perception, and low acceptance. This study aimed to assess the direct and interactive impacts of COVID-19 vaccine risk perception and acceptability on COVID-19 vaccination attitudes in the general Nigerian population. In a cross-sectional approach, participants completed a structured questionnaire including demographics, COVID-19 vaccine risk perception, acceptance, and vaccination attitude from April 2-30, 2021. The sample included 1,026 participants from different ethnicities across four regions (Southwest, South, Southeast, and North Central) in Nigeria, which were selected using the convenience sampling method. Multivariate analysis of variance results showed that the COVID-19 vaccine’s risk perception and acceptability have separate and interactive effects on overall vaccination attitudes. Interactively, individuals with high-risk perceptions and low acceptance expressed more skepticism about its benefits, were concerned about its long-term body effects, believed more in its commercialization, and preferred natural immunity. Nigerians’ apprehension about COVID-19 vaccination is impacted by their high-risk perception and low vaccine uptake.
Effects of Using an Application for Postpartum Contraceptive Use in Family Planning Counseling During Pregnancy
Authors: Nurcahyani Lia , Widiyastuti Dyah , Iman Arief Tarmansyah , Cahyati Yanti , Fitrianingsih Yeni
Published: August 2023

A decision-making tool for family planning flipchart is used for contraceptive counseling, but the use of this flipchart is suboptimal. In this study, primary study resulted in innovative decision-making tools for family planning applications. “Si KB Pintar” was also developed, a tool that women can use to discuss contraceptives with their husbands after family planning counseling. This study analyzed the effectiveness of family planning counseling during pregnancy by applying postpartum contraceptive use. Analytical quantitative quasi-experimental methods were used with a control group design. The sampling method was two-stage sampling. In the first stage, from 22 primary health care (PHC) in Cirebon City, Indonesia, 11 intervention and 11 control groups were selected using random allocation. Five participants were taken from each PHC in the second stage using simple random sampling. The findings indicated that participants given family planning counseling using an application had a 2.4 times higher likelihood of using postpartum contraception compared to flipcharts after controlling for age and parity variables. Because these applications are only for Android users, applications should be produced that all users can utilize in further study.
Knowledge and Pattern of Preventive Behaviors Among Relatives of Breast Cancer Patients in Yogyakarta Pre and During the COVID-19 Pandemic
Authors: Triratnawati Atik , Mulyasari Runavia
Published: August 2023

Breast cancer is still one of the leading causes of death in Indonesia. The multifactorial causes of breast cancer, including heredity, carries a risk for the sufferers’ relatives. Vigilance in female relatives of breast cancer patients increases due to hereditary risk factors for having the same disease. This anthropological study aimed to reveal the mosaic of breast cancer patients’ female relatives’ knowledge of such a risk and their efforts to prevent it. Qualitative data collection through interviews was conducted with 13 female family members of breast cancer patients in Yogyakarta aged 17-65 years. The data analysis was done through an emic approach by examining the informants’ views on the situation and their solutions. All of the informants believed that breast cancer is a malignant and deadly disease if it is not detected early and not properly treated. They were all fully aware of their risk as a family member to have the same disease. Their preventive measures included medical (early examination, breast self-examination, laboratory check, or consultation with the doctor) and non-medical (changes in eating and drinking behavior, reducing stress, exercising, and wearing masks). Besides, they also made religious efforts by praying to God to be given a healthy life and for the patients to be healed and their offspring to be free from this disease.
Epidemiology of Celiac Disease in Northern Morocco in 2018–2021: A Descriptive Cross-Sectional Study
Authors: Haddadi Maroua , Mellouki Ihsan , Benmakhlouf Yousra , Diakite Adama , Khaili Ayman , Barrijal Said , Essalmani Haiat
Published: August 2023

Celiac disease is an autoimmune disease caused by gluten. This retrospective cross-sectional study with descriptive and analytical aims was conducted over three years, from 2018 to 2021. The participants were 280 patients diagnosed with celiac disease registered in the Gluten Intolerant and Allergic Association of the North in the Tangier-Tetouan-Al Hoceima region. The prevalence and incidence of celiac disease in this region were 1/135 and 1/253, respectively. The average age was 21.18 ± 1.13, and the first symptoms appeared between 10 and 25 years. The data showed a female predominance of 68% versus 32% for males, with a male/female sex ratio of 0.45. The clinical signs of celiac disease manifested more in gastrointestinal symptoms. This study obtained data on 22.6% of microcytic hypochromic anemia patients and 40.7% of Helicobacter pylori infections. In addition to celiac disease, the patients showed other pathologies with different rates: repeated spontaneous abortions (2.14%), type 1 diabetes mellitus (1.42%), autism (1.42%), dermatitis herpetiformis (0.72%), cancer(0.72%), and epilepsy (0.35%). Serologically, anti-transglutaminase antibodies were positive in 47.2% of patients. Analyses of histological data from intestinal biopsies from 141 patients were positive in 50.8% of patients. There was a minor correlation between the serological profile and the degree of atrophy.
Clinical and Functional Outcomes of COVID-19 Survivors After Hospitalization
Authors: Nazir Arnengsih , Putri Salsabila S S , Bashari Muhammad Hasan
Published: August 2023

Coronavirus disease 2019 (COVID-19) causes various clinical manifestations during acute infection and at the post-acute phase with persistent symptoms called long COVID. It occurs in mild and moderate to severe cases which require hospitalization. In patients needing hospitalization, especially intensive care unit admission, the risk of long COVID increases. Many hospitalized patients exhibited more symptoms in 60 days after the illness than non-hospitalized patients. This review aimed to identify the clinical and functional outcomes in COVID-19 survivors after hospitalization. The articles in the PubMed database published in 2019-2021 were reviewed and found 20 be eligible. The clinical outcomes were the appearance or persistence of general and multi-organ symptoms, nutritional disorders, and decreased lung function. The functional outcomes found were decreased muscle strength, physical, psychological, and cognitive functions, increased disability and dependencies, as well as decreased vocational status and quality of life. The incidence of each outcome could not be determined due to the variety of methods used to examine and present outcomes. To conclude, COVID-19 causes long-term clinical and functional outcomes that need to be identified to prevent and manage long-term physical and functional disorders.
Oral Manifestations in COVID-19 Patients Associated with Oral Hygiene in Aceh, Indonesia: A Literature Review
Authors: Hanum Misra , Abdat Munifah , Nurjannah Nurjannah , Saputra Irwan , Usman Said
Published: August 2023

COVID-19 became a pandemic because of its high-speed transmission via salivary and airborne droplet routes. Viruses can enter host cells through ACE-2 receptors in various human organs, including the oral cavity. The oral manifestations that arise include white plaque, ulceration, burning sensation, oral mucositis, depapillation of the tongue, dry mouth, halitosis, and loss of the sense of taste. Poor oral hygiene, comorbidities, decreased immunity, and stress can exacerbate these manifestations. This review study aimed to report various oral manifestations of COVID-19 related to oral hygiene. Relevant articles were identified from PubMed, ScienceDirect, Elsevier, and Google Scholar. Out of the 60 articles selected, only 36 could be reviewed. The World Health Organization recommends early detection for individuals with suspected exposure to the COVID-19 virus to control its spread, including checking for oral manifestations. Oral hygiene is an important factor affecting the manifestations of the oral cavity of COVID-19 patients, so examination of the condition of oral hygiene is recommended in the medical management of COVID-19 patients. To conclude, oral hygiene is related to the emergence of oral manifestation in COVID-19-infected patients.
Workers’ Characteristics of Hearing Loss at Soekarno-Hatta International Airport, Indonesia
Authors: Timanta Andrew Ebeneizer , Haryanto Budi , Wulandari Ririn Arminsih
Published: August 2023

This study aimed to analyze the characteristics and factors of worker behavior, including age, the use of ear protection, work duration, a record of diabetes mellitus or hypertension, work rotation, and noise hazards involved in hearing loss in PT. X at Soekarno-Hatta International Airport, Indonesia. A cross-sectional study from May 2017 to June 2017 involved 73 workers in the power service area (TZ Unit) exposed to noise levels <85 dBA and ≥85 dBA, using an audiometry test for hearing loss and Sound Level Meter for noise hazards was conducted. The Chi-square test showed a significant correlation between age (OR 8.4, 95% Cl = 1.6-44.1), work duration (OR 7.6, 95% Cl = 0.9-67.2), and the use of ear protection (OR 7.8, 95% Cl = 1.4-44.2) with hearing loss in workers in the power service area. The multivariate analysis revealed that workers exposed to a noise level of 85 dBA had a 1.7 times greater risk of hearing loss than workers exposed to a noise level of <85 dBA after controlling for age, work duration, use of ear protection, medical history, and work rotation.
Plan de negocio para la creación de una agencia de medios digitales enfocados en Mypes
Authors:   , Fernández Ramos Carlos Gerardo , Karr Carreón Luis Eugenio
Published: August 2023

La presente investigación, se desarrolla con el propósito de tener mayor competitividad y ser mejor estructurada, realizado a base de esfuerzo, mediante la recopilación de la información y con la participación de los directores, el cual busca determinar factores potenciales en el mercado a ingresar teniendo en cuenta la escasez de estrategias de Marketing Digital en el mercado nacional. Para comenzar el análisis, se examina factores externos de la empresa, para que se ajuste al escenario de la actualidad del país. Por otro lado, los factores internos fueron claves para conocer la actualidad de la empresa en el uso de herramientas de comunicación masiva, en esta etapa se determinan las debilidades y fortalezas de la empresa frente al desarrollo de cada punto. En la fase exploratoria, se realizaron los diseños de las estrategias de marketing, mediante el uso de los datos cuantitativos. La formulación de objetivos se planteó basado en las necesidades actuales por mejorar y las oportunidades que nos brinda el mercado de MYPES, en las tácticas a utilizar fueron consideradas el precio, productor, promoción y plaza, esenciales para cumplir con las estrategias del estudio. El análisis financiero, indica que la inversión de s/. 34,556.42 soles, arrojan resultados positivos, generando rentabilidad para nuestra consultora llamada “TARGET” que será importante para seguir brindando este tipo de asesorías personalizadas para cada mediana y pequeña empresa que no esté desarrollando estrategias de marketing digital. Las estrategias propuestas, provocará un impacto en el incremento en los ingresos de la organización, para así mantenerla en el mercado donde opera y de la misma forma, concientizar a más personas sobre su presencia.
Efficiency and effectiveness of two different solvents in retreatment of teeth obturated by bioceramic sealer
(A Comparative In-Vitro Study)
Authors: Refky Nada
Published: August 2023

The bioceramic sealer removal is a great challenge that need to be solved. Therefore, the current study had 3 main objectives. The first is to evaluate and compare the efficacy of 10% FA and 20% HCl, for the retreatment of teeth obturated with gutta-percha and BC sealer, the second is to evaluate the effect of the solvents on root canal wall dentin and compare the level of erosion caused by these solvents and the third to evaluate micohardness of the tooth.
Methods : twenty-six extracted single-canal teeth are instrumented and obturated 1 mm short of the working length using gutta percha and ceraseal BC sealer. Two weeks later, gutta-percha is removed and assessment is done on two groups: Formic acid group and hydrochloric acid group. Both groups are tested. Apical patency is attempted with a c-file and a solvent. The time to gain patency through BC sealer is recorded, then full removal of bioceramic sealer using FKG Race EVO rotary files with solvents. Scanning electron microscope is used to test the amount of remaining sealer and the effect of solvents on dentin, microhardness of dentin is tested as well.
Categorical Risk Stratification for Neonatal Early Onset Sepsis using Suspected Intraamniotic Infection and the Newborn Exam
Authors: Rick Anne-Marie , Copp Elizabeth , Buckley Abigail , Yanowitz Toby , Martin Judith , Shaikh Nader , Switzer Galen , Hooven Thomas , Beigi Richard
Published: August 2023

Objective: To determine test characteristics of categorical risk stratification for early onset sepsis (EOS) using maternal criteria for suspected intraamniotic infection (IAI) and/or newborn exam and compare them to the EOS calculator.
Study Design: Retrospective 1:3 case-control study of late preterm/term infants with bacterial culture growth obtained <72 hours of life. For categorical approach, infants of mothers with suspected IAI or equivocal/ill appearing were presumed high-risk for EOS and blood culture obtained. For calculator, estimated probability of EOS and care recommendations were recorded from online calculator. Test characteristics were compared with McNemar’s test; recommendation for blood culture was considered a “positive” test.
Result: 52 cases and 172 controls were included. Compared to the calculator, the categorical approach had higher sensitivity 90%(95%CI:79-96%) vs 67%(95%CI:54-79%) but lower specificity 85%(95%CI:78-89%) vs. 92%(95%CI:87-96%). 10% of cases were not identified by either.
Conclusion: A categorical approach using suspected IAI/newborn exam offers good EOS discrimination and is comparable to the calculator.
Factors Predicting Spontaneous Closure of Patent Ductus Arteriosus in Very Low Birth Weight Neonates
Authors: Depala Kiran , Atkinson Helen , Budhani Shaaista , Yitayew Miheret , Mydam Janardhan
Published: August 2023

Background: Management of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) neonates remains a challenge. Accurate prediction of spontaneous PDA closure could allow selective medical treatment and prevent unnecessary medical intervention.
This study aims to evaluate potential variables as predictors of spontaneous closure of hsPDA in VLBW infants.
Methods: We conducted a retrospective review of VLBW infants born from 2006 to 2014 at our institution. Infants included in the study were diagnosed with moderate to large hsPDA on echocardiogram in the first week of life. We divided our population into 2 study groups: PDA closure before discharge without medical/surgical treatment (spontaneous closure) and PDA closure by medical or surgical treatment warranted by critical clinical status. Relevant baseline data and PDA-related parameters were extracted from the medical records. Statistically significant variables were further analyzed using a multiple logistic regression model to identify potential independent predictors of spontaneous closure.
Results: 108 infants were included in the study; 52 had spontaneous PDA closure and 56 required treatments. Of the baseline characteristics, only gestational age and mode of delivery differed significantly between infants with spontaneous closure and those who required treatment. Significant variables included hematocrit and fluids received on day 1 of life, pre-diagnosis mean pH, PCO2, serum bicarbonate, average fluid goal, and average urine output. After multiple logistic regression analysis, controlling for statistically significant and clinically relevant variables, Cesarian section (OR, 0.18, 95% CI, 0.06-0.55; P=.003), average pre-diagnosis PCO2 (OR, 0.92; 95% CI, 0.86-0.98; P=0.008) and pre-diagnosis daily fluid received (OR, 0.96; 95% CI, 0.94-0.99; P=0.03) were independent predictors of spontaneous closure. Sensitivity and specificity analysis of predictor variables revealed highest sensitivity cut-off points of 40 mm Hg (71.2%) for PCO2, 104 mL/kg/d (71.2%) for fluid goal and highest specificity cut-offs of 64 mm Hg (91.1%) and 158 mL/kg/d (96%), respectively.
Conclusion: In our study of VLBW infants, lower average pre-diagnosis CO2, lower daily fluid goal, and vaginal birth were associated with increased likelihood of spontaneous hsPDA closure.
The Kidney Volume-to-Birth Weight Ratio as a Surrogate Indicator for the Number of Nephrons in Extremely Low Birth Weight Preterm Infants
Authors: Villani Gabriele , Zaza Pierluigi , Lamparelli Raffaella , Maffei Gianfranco
Published: August 2023

Background: In humans, nephrogenesis is completed 4-6 weeks after birth. Premature birth interrupts renal development and maturation. In Neonatal Intensive Care Units (NICUs), harmful factors for premature infants increase the risk of hypertension, cardiovascular diseases, and renal failure in adulthood. The aim of this study is to identify preterm infants with a low number of nephrons at birth for appropriate surveillance and targeted care.
Methods: Between March 2018 and March 2021, 29 extremely low birth weight premature infants (ELBW) were enrolled, including 25 appropriate for gestational age (AGA) and 4 small for gestational age (SGA). For each infant, body weight was recorded, and single and combined renal volume, as well as relative renal volume (the ratio of renal volume to body weight), were calculated using ultrasound. These measurements were taken one week after birth and every 2 weeks up to 38-40 weeks post-menstrual age (PMA), as well as at 6, 12, 18, and 24 months of PMA. Pearson's correlation coefficient was used to evaluate the strength of the correlation between renal volume and body weight for each infant.
Results: The Pearson's coefficient showed a strong positive correlation for all infants from one week after birth to 38-40 weeks of PMA and from 38-40 weeks to 24 months of PMA.
Conclusions: The ratio of kidney volume to birth weight appears to be a more reliable indicator for estimating the number of nephrons at birth. The identification of infants with a lower number of nephrons allows for more appropriate follow-up, thereby reducing the risk of developing kidney failure in adulthood.
Clinical efficacy of nucleoplasty for uncontained lumbar disc herniation: A retrospective study
Authors: Choi Yong Cheol , Seo Jong Hun , Kim Pius
Published: August 2023

Background
There are insufficient in-depth studies on whether percutaneous lumbar nucleoplasty (PLN) is effective and safe for the treatment of uncontained lumbar disc herniation (ULDH). This study aimed to investigate the clinical efficacy of PLN on radiating leg pain caused by ULDH.
Methods
Patients who underwent PLN for ULDH and met the inclusion criteria between June 2018 and July 2022 were included. Clinical outcomes were evaluated using the numeric rating scale (NRS) for radiating pain preoperatively; at 1 day, 1 week, and 1 month postoperatively; and at the last follow-up. Patient satisfaction was assessed using MacNab criteria.
Results
Forty-one patients were enrolled. The mean age was 50.2 years (range 24–73 years). The mean and standard deviation of the preoperative NRS in 39 patients with radiating pain was 9.0 ± 1.2. The NRS scores at 1 day, 1 week, and 1 month postoperatively and at the last follow-up were 4.6 ± 3.2, 3.6 ± 3.3, 2.9 ± 3.2, and 1.4 ± 2.0, respectively, showing significant improvement (all, p < 0.001). The number of patients (percentage) with excellent or good satisfaction according to the MacNab criteria was 29 (70.7%). Major complications were not observed. Three patients underwent additional surgery after PLN because of persistent radiating pain.
Conclusions
PLN is a safe and feasible treatment option for ULDH. Treatment outcomes were favorable on average; however, the lack of consistency was a drawback.
Social-ecological factors influencing loneliness and social isolation in older people: A scoping review
Authors: Meehan Drew Eleanor , Grunseit Anne , Condie Jenna , HaGani Neta , Merom Dafna
Published: August 2023

There are growing calls from researchers and policy makers to redefine loneliness and social isolation (SI), as public health issues, and to move towards a transdisciplinary, systems-based approach, due to their association with significant health risks, particularly in older people. Research about loneliness and SI in older people has typically adopted a narrow focus, evaluating effects of individual and inter-personal factors on these experiences. Less is known about the community and societal influences that may be used to inform public health interventions. We conducted a scoping review applying Joanna Briggs Institute methodology and the social-ecological model framework in order to: i) identify the available evidence for the influence of the community and societal factors on loneliness and SI as experienced by older people; ii) examine how quantitative research about community- and societal-level factors of loneliness and SI in the older population is conducted; and iii) identify current knowledge gaps in relation to the use of the social-ecological model in this area. A total of 52 articles from 30 countries met the inclusion criteria, including 33 observational studies, primarily cross-sectional (88%), and 19 interventions, mostly (89%) pre-post evaluations. The majority of included articles measured loneliness only (n = 34, 65%), while 11 measured both loneliness and SI (21%). To measure these outcomes validated scales were frequently used. Eighteen community/societal factors were investigated in relation to loneliness and/or SI, most commonly, neighbourhood safety, access to public third-places and cultural practices. Three societal-level interventions were found: two campaigns to reduce ageism and one explored the impact of free public transport. Community-based interventions were either educational or enlisted volunteers to foster connections. There is a need for longitudinal studies to better understand the mechanism through which community- and societal- level factors affect loneliness and SI, which in turn guide interventions that utilise the social-ecological framework to these issues.
Improving the economic growth of smart cities based on wireless sensor networks
Authors: Yuan Chao , Zhao Ziqi
Published: August 2023

Although city economic growth is not linear in nature, it does typically display some instability. A particular level of financial volatility might be damaging to the growth of the urban economy. This paper focuses on the present state of the city's economy in order to address the financial losses brought on by the significant economic instability the city-wide. Throughout its growth phase, the global economic inspection, warning advancements in networks and data warehouses, and wireless sensor devices were examined, assessed, and stated the significance of Internet of Things (IoT) devices in the financial early warning mechanism investigated the growth procedure for financial tracking, contrasted a number of popular financial keep techniques, and suggested the utilization of IoT devices for urban financial surveillance, the concept of early warning, and the creation of an urban economic information system and a collection of IoT devices, the urban financial information surveillance, and early alerting system has conducted studies regarding the transfer of data, surveillance, projections, manufacturing, and presentation. Following the model simulation, the outcomes of the simulated research reveal that the system's financial instability forecast precision exceeds 81%, which has some practical relevance.
An Augmented Salp-swarm Optimization Based on Paillier Federated Multi-layer Perceptron (Pf-mlp) and Homomorphic Encryption Standard (Hes) Techniques for Data Security in Cloud Systems
Authors: S Kanakasabapathi R , Judith J.E.
Published: August 2023

Providing security to cloud data is one of the essential problems that have needed to be addressed in recent times due to the advancement and development of security breaches in technologies. As a result, the majority of existing research efforts aim to develop various types of cryptographic techniques for ensuring the data security of cloud systems. However, it faced challenges with complex computational operations, inefficient security models, high time consumption, and error outputs. Therefore, the proposed work aims to develop an advanced and hybrid optimization-based cryptographic methodology for increasing the security of cloud data. An Improved Salp-Swarm Optimization (ISSO) technique is deployed to obtain the random number required for secret key generation. In this work, two different encryption techniques, such as the Homomorphic Encryption Standard (HES) and the Paillier Federated Multi-Layer Perceptron (PF-MLP) model, are used for strengthening the security of the original health tweet dataset. Here, the efficacy and security level of these two encryption methodologies are validated for the purpose of identifying the most suitable mechanism to secure the health tweet dataset. For these approaches, the key pair is optimally generated by using an ISSO technique. This type of key generation can complicate matters for users who attempt to attack the original information. Moreover, the novel contribution of this work is that it incorporates the functions of advanced optimization and cryptographic mechanisms for securing the health tweet dataset against attacking users. For validating the performance of this system, various evaluation metrics have been used, and the validated results are compared with the proposed system to demonstrate the improvement of the proposed system.
Aetiology of community-acquired pneumonia among infants and children at a hospital in Vietnam: screening for multiple pathogens using molecular methods
Authors: Tran Xuan Duong , Hoang Van-Thuan , Goumballa Ndiaw , Vu Thi Nguyet , Tran Trong Kiem , Pham Thi Dung , Dao Thi-Loi , Vu Thi Thuy , Nguyen Duy Cuong , Nguyen Quoc Tien , Marty Pierre , Gautret Philippe
Published: August 2023

Objective: To investigate potential respiratory pathogens in children with community-acquired pneumonia (CAP) and risk factors for severe disease in a Vietnamese hospital.
Methods: Clinical data and laboratory results were collected. Twenty-four respiratory pathogens were tested from nasopharyngeal swabs using real-time PCR.
Results: 467 children with CAP were included, mean age = 15.4±13.3 months, 63.0% were male. Over 97% of patients had a positive PCR result. Majority of patients (87%) were positive for multiple (up to eight) pathogens. Rhinovirus (46%), respiratory syncytial virus (RSV) (24%), enterovirus (17%), and parainfluenza viruses-3 (13%) were the most frequent viruses. H. influenzae (61%), S. pneumoniae (45%) and M. catarrhalis (30%) were the most common bacteria. 128 (27 %) cases were classified as severe pneumonia. Presence of smokers at home, CRP level ≥ 50 mg/dL, RSV and H. influenzae PCR detection associated with a higher risk of severe pneumonia (aOR=2.11, P value=0.004; aOR=6.11, P value<0.0001; aOR=1.78, P value=0.03 and aOR=1.66, P value=0.04, respectively).
Conclusion: Causative agents of pneumonia in children are complex. Case-controlled and metagenomic studies need to be performed to further investigate the role of the presence of microbial agents in the respiratory tract on pneumonia in children to differentiate between colonisation and infection.
Unraveling the Relationship Between Cultural Food Habits and Chronic Obstructive Pulmonary Disease in Men: A Case-Control Study in Kazakhstan
Authors: Turdaliyeva Botagoz , Kulzhanov Maksut , Akhmetov Valikhan , Auyezova Ardak , Yussupova Nargiza , Karibayeva Indira
Published: August 2023

Background: Limited research has been conducted on the association between cultural food habits (CFH) and the risk of chronic obstructive pulmonary disease (COPD), and no studies have specifically investigated the long-term dietary impact on COPD risk in the Republic of Kazakhstan [1]. However, the prevalence of various non-communicable diseases, including COPD, is high in the country, and some of these diseases may be influenced by CFH. To better understand the relationship between CFH and non-communicable diseases, the Ministry of Healthcare of the Republic of Kazakhstan has provided funding for research through grant number OR12165486, titled "National Programme for the Introduction of Personalized and Preventive Medicine in The Republic of Kazakhstan (2021–2023)" (Grant number OR12165486). The current case-control study is being conducted as part of this grant.
Aim: We sought to investigate the association between long-term red meat consumption and risk of COPD.
Methods: The case – control study primarily targeted the population of the Almaty Observational Cohort, comprising 609 men aged 30 to 85 years. These participants were monitored for analysis purposes between 2018 and 2023, with an average age of 51.2 years (95% CI 48.1–54.3). The assessment of unprocessed and processed red meat consumption was conducted using a self-administered questionnaire in both 2018 and 2023.
Results: Among individuals with COPD, the predominant factors associated with the disease were the consumption of red meat more than 10 times per month (84.9%), a body mass index (BMI) over 25 (73.6%), the consumption of more than 100 grams of red meat per serving (62.3%), and the consumption of less than 100 grams of fresh fruits per serving (52.8%). In the control group, the primary factors were alcohol consumption in the past 12 months (69.2%), the consumption of red meat more than 10 times per month (62.9%), the consumption of more than 100 grams of red meat per serving (55.8%), and the consumption of fresh fruits less than 30 times per month (52.0%).
Conclusion: The findings suggest that high consumption of red meat, low consumption of fresh fruits and vegetables, and a preference for fatty foods may increase the risk of developing COPD among men in Kazakhstan. These results emphasize the importance of promoting balanced and healthy dietary habits to reduce the burden of COPD and improve public health.
A Risk Predictive Model for the Severity of Illness in Patients with Severe Fever with Thrombocytopenia Syndrome
Authors: Tao Shuai , Wu Yiran , Zhang Aiping , Liang Manman , Wang Zijian , Yang Jianghua
Published: August 2023

Background
Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified infectious disease characterized by a high mortality rate and wide prevalence. The objective of our study was to investigate the factors that influence the severity of SFTS and develop a predictive model applicable to primary care settings.
Methods
This retrospective study examined a cohort of 169 patients with SFTS who received medical attention from May 2015 to February 2022. Clinical and laboratory data were compared between the mild and severe groups. Independent risk factors contributing to the severity of the patients' condition were assessed using multifactorial logistic regression analysis. Subsequently, a nomogram was constructed based on the outcomes of the regression analysis. The predictive model's discrimination and calibration were evaluated using metrics such as the concordance index (C-index), ROC curve, and Hosmer-Lemeshow analysis.
Results
A total of 169 patients diagnosed with SFTS were included in this study. A comprehensive analysis of 19 factors was conducted, including AGE, neurological manifestations, PLT, NEUT%, MONO%, CK, CK-MB, LDH, ALT, AST, BUN, Cr, Ca, APTT, PCT, HCT, ALB, HCT-ALB, and HGB. Logistic regression analysis revealed that PLT (OR = 0.930, 95% CI = 0.892–0.970), CK (OR = 1.005, 95% CI = 1.001–1.008), APTT (OR = 1.042, 95% CI = 1.002–1.083), LDH (OR = 1.004, 95% CI = 1.000-1.007), and NEUT% (OR = 1.062, 95% CI = 1.020–1.106) were identified as independent risk factors for disease severity. The constructed nomogram exhibited excellent predictive performance in estimating severe disease (C-index = 0.927, AUC = 0.927, sensitivity = 84.4%, specificity = 87.3%, Hosmer-Lemeshow analysis SD = 0.00051, and quantile of absolute error = 0.036).
Conclusions
Decreased PLT, increased LDH, CK, APTT, and NEUT% serve as reliable predictors of severe disease progression in patients with SFTS. Utilizing these five predictors, a predictive line chart exhibits strong capability in accurately assessing the risk of severe disease during the course of the illness.
Biomaterial composed of chitosan, riboflavin and hydroxyapatite for bone tissue regeneration
Authors: Gaweł Justyna , Milan Justyna , Zebrowski Jacek , Płoch Dariusz , Stefaniuk Ireneusz , Kus-Liśkiewicz Małgorzata
Published: August 2023

Bone tissue engineering is an ongoing field of research due to the existing of burning needs in restoration and reconstruction of damaged bone. Numerous studies have shown the development of the biomaterials based on the hydroxyapatite, major component of bones. Biomaterials engineering approaches involve using a combination of miscellaneous bioactive molecules which may promote cell proliferation, and thus, forming a scaffold with the environment which favor the regeneration process. Chitosan, naturally occurring biodegradable polymer, possess some essential features, i.e biodegradability, biocompatibility, and in solid phase good porosity, which may be contributed to promote cell adhesion. Moreover, doping the materials with other biocompounds, will create a unique and multifunctional scaffold useful in regenerative medicine. Riboflavin is an essential water-soluble vitamin, which participates in numerous biological process, such as transport, cell development and reproduction. Therefore, this study is focused on the manufacturing of the composite materials based on the hydroxyapatite, chitosan and riboflavin. Scanning electron microscopy showed the porosity of the composite biomaterial, important factor which can affect cell ingrowth and new bone formation. The infrared spectroscopy demonstrated chemical interlinking between hydroxyapatite and chitosan phases as well as no evidence for chemical interaction between RF and the CS-HAP scaffold. This may alter physical and chemical properties of the scaffold towards better performance in potential regenerative applications, particularly, when the matrix is supplemented with RF. Indeed, in vitro experiments showed that the riboflavin increased the cell proliferation and migration of the fibroblasts and osteosarcoma cells. Due to the urgent need of development of material with a potential to prevent of implant-associated infections, the antimicrobial and antioxidant activity of the composite were determined. The composite material showed the inhibitory effect on Staphylococcus aureus and exhibited higher antioxidant activity compare to pure chitosan. The antibacterial effect may be due to the generation of ROS level. Moreover, the riboflavin photochemical treatment with blue LED light enhanced the ROS level, which could be a more accessible and safe practice to treat the implant-associated infections. All things considered, incorporating riboflavin into the biocomposite scaffolds may accelerate new bone regeneration.
BAP31 promotes breast cancer progression by interaction with SERCA2
Authors: Liu Xiangtian , Xu Qiao , Qian Wenchang , Guan Haiyang , Jiang Dongbo , Yu Fazhi , Guo Qianying , Wu Mingming , Zhang Xiao , Zhang Weijie , Li Gaopeng , Yang Zhenye , Wu Zhengsheng , Pandey Vijay , Han Xinghua , Ma Xiaopeng , Lobie Peter E. , Yang Kun , Zhu Tao
Published: August 2023

Background
B-Cell receptor-associated protein 31 (BAP31) is a resident chaperone protein in the endoplasmic reticulum. It was observed herein that a higher expression of BAP31 mRNA was associated with a worse prognosis in breast cancer patients.
Methods
Breast cancer cells and normal breast tissue cells were used to confirm how BAP31 influences the progress of breast cancer both in vivo and vitro. Western blots and qRT-PCR assays supported the changes.
Results
Depletion of BAP31 in breast cancer cells increased apoptosis and decreased the capacities of proliferation, colony formation and invasion. BAP31 was observed to be associated with SERCA2, a sarco/endoplasmic reticulum Ca2+-ATPase. Depletion of BAP31 decreased endoplasmic reticulum Ca2+ storage with resultant ER stress and breast cancer cell death; which required BAP31 association with SERCA2 .
Conclusion
Hence, these findings have demonstrated that BAP31 enhanced the viability, oncogenicity and motility of breast cancer cells by modulation of endoplasmic reticulum Ca2+ homeostasis. Thus, BAP31 promotes progression of breast cancer.
Physical Interpretation of the morphology in the relaxation mechanism of Ba Hexagonal Nano-Ferrites (BaCoxCdxFe12-2xO19): Impedance Modelling, AC conductivity, dielectric modulus, and electrical modulus parameters
Authors: Singh Charanjeet , Jain Ankit , Godara Sachin , Jotania Rajshree , Kaur Varinder , Sood Ashwani
Published: August 2023

This study describes in detail the sol-gel synthesis of doped M-type Ba hexagonal ferrite with Co2+ and Cd2+. In order to explore the crystal structure and grain morphology, X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) have been used. At room temperature, the dielectric, impedance, electric modulus, and conductivity characteristics were investigated using an impedance analyzer, as well as the physical interpretation of morphology in the relaxation mechanism. The structural parameters indicated the formation of hexagonal M-type crystal structures. Doping with large quantities of Co2+ or Cd2+ caused the unit cell to become smaller, which in turn reduced the lattice constants to lower values. The examination of grain morphology revealed that the doping led to the formation of needle-like grains. The change of AC conductivity from 0.00022 to 1.04*10− 7 Ωm− 1 with frequencies ranging from 1 KHz to 2 MHz demonstrated that the electron hopping process was the primary cause of the high electrical conductivity in these ferrites. As a function of doping, the dielectric spectrum analysis showed that there was a decrease in the dielectric constant and an increase in the loss tangent. Within the frequency range of 1 KHz to 2 MHz, the fluctuation of the dielectric constant (ε′) from 135.94 to 3.59 and the loss tangent (tan σ) from 3.67 to 0.11 was observed. The relaxation of conductivity was seen for different levels of composition, which correlated with the non-Debye type of behaviour proven by the electric modulus spectra. Both relaxation time and AC conductivity decreased with doping. The conductivity relaxation and dielectric relaxation contributed to the charge transport mechanism in the BaCoxCdxFe12−2xO19. Electrochemical impedance spectroscopy software resulted in impedance curves that corresponded with empirically measured impedance values. There was consistency between the calculated grain and grain boundary characteristics as well as the distribution of grains /grain boundaries observed in the micrographs.
RIG-I Promotes Cell Proliferation in Esophageal Squamous Cell Carcinoma by Facilitating p21 Degradation
Authors: Wang Meng , Zhang Yangyang , Gao Liping , Zhang Hailin , Yang Zhenwei , Liu Jialong , Shan Wenqing , Zeng Lingxiu , Zhang Ranran , Li Yong , Liu Jing
Published: August 2023

Background
Retinoic acid-inducible gene-I (RIG-I) is considered a key sensor for host recognition of RNA virus infections. Recent studies have shown that RIG-I also regulates carcinogenesis. However, the role of RIG-I in esophageal squamous cell carcinoma (ESCC) remains unclear.
Method
We investigated the RIG-I expression in ESCC cells using a public database, immunohistochemistry, and Western blotting. We evaluated the proliferative activity of ESCC cells using CCK-8, colony formation, and EdU staining assays. Further, we determined the ESCC cell cycle changes using flow cytometry and the ubiquitination of p21 in the cells using cycloheximide chase and ubiquitination assays. Finally, we verified the in vivo effects of RIG-I on ESCC cells by constructing xenograft models.
Results
RIG-I was highly expressed in ESCC cells and significantly promoted their proliferation and cell cycle. Moreover, RIG-I knockdown inhibited xenograft growth in nude mice. Furthermore, RIG-I accelerated the cell cycle by promoting the ubiquitination and degradation of p21.
Conclusion
Overall, this study revealed that the increased expression of RIG-I due to ESCC accelerated the progression of esophageal cancer by promoting the ubiquitination and degradation of p21, which is related to the prognosis of ESCC. Thus, RIG-I may be a novel therapeutic target for ESCC treatment.