bluuebunny/crossref_metadata_2025 huggingface dataset:
Dekonstruksi Hidangan Penutup Dingin Tradisional Indonesia Menjadi Fusion Dessert
Authors: Krisna Yanti Ni Made Ayu Dwi , Tanius Billy , Widani Ni Nyoman , Pramudia Heru
Published: January 2023

Makanan saat ini tidak hanya menjadi kebutuhan pokok melainkan menjadi gaya hidup yang lebih modern bagi pecinta kuliner, saat ini kuliner khas Indonesia mulai tergeser keberadaannya dikarenakan adanya tren budaya baru yang datang ke Indonesia maka dari itu peneliti tertarik untuk mendekonstruksi jajanan khas dari beberapa daerah di Indonesia. Metode penelitian yang digunakan ialah metode penelitian deskriptif atau penelitian pengembangan research and development, dengan model 4D model penelitian yaitu (Define, Design, Development, dan Dissemination). Dalam penelitian ini, peneliti akan menggunakan Kuesioner sebagai instrumen penelitian untuk mencari pendapat tentang dekonstruksi jajanan dan minuman khas Indonesia menjadi hidangan penutup dingin modern. Digunakan panelis sebanyak 23 orang. Hasil dari penelitian menciptakan 10 resep makanan tradisonal penutup dingin yang didenkonstruksi yaitu Es Cendol, Es Brenebon, Es Kolak Pisang, Es Oyen, Es Doger, Es Teler, Klepon, Es Laksamana Mengamuk, Es Sarang Burung, dan Es Pisang Ijo. Semua resep telah di tes dari segi warna, rasa, aroma dan juga tekstur, dan hasilnya banyak dari panelis yang menyukai hasil dekonstruksi hidangan penutup dingin khas Indonesia menjadi hidangan penutup dingin dalam bentuk entremets. Hidangan penutup dingin yang sudah didekonstruksi memberikan tampilan yang berbeda tetapi masih mempertahankan cita rasa tradisional dan diterima dengan baik berdasarkan hasil penilaian para panelis.

Kata Kunci: Dekonstruksi, Makanan Penutup Dingin, Entremets, Jajanan Tradisional Indonesia
Peran Perempuan Dalam Kegiatan Pariwisata Di Pantai Oetune (Studi Kasus Pada Desa Tuafanu Kabupaten Timor Tengah Selatan)
Authors: Nugraha Yudha Eka , Balukh Helen I. S.
Published: January 2023

Pantai Oetune merupakan daya tarik wisata berbasis alam di Kabupaten Timor Tengah Selatan (TTS). Secara geografis, Pantai Oetune berdekatan dengan masyarakat setempat penduduk Desa Tuafanu. Hal ini memungkinkan interaksi antara masyarakat lokal dan turis di Pantai Oetune terutama kelompok masyarakat perempuan yang menunjang kegiatan pariwisata di Pantai Oetune. Tujuan penelitian ini yakni mengetahui
peran perempuan pada kegiatan pariwisata di daya tarik wisata pantai dengan pendekatan metode kualitatif. Wawancara dan observasi merupakan teknik pengumpulan data yang digunakan dalam penelitian. Penelitian ini mengidentifikasi bahwa peran perempuan dalam kegiatan pariwisata di Pantai Oetune terbagi menjadi tiga yakni (1) Peran Perempuan dalam atraksi wisata seperti tari-tarian, menenun, melestarikan budaya lokal berupa kebiasaan lokal, (2) peran perempuan dalam pengelolaan fasilitas wisata seperti homestay, makanan minuman, memasarkan cenderamata, (3) Peran perempuan dalam pengelolaan organisasi pariwisata. Selain peran, terdapat beberapa kendala dalam mendukung kegiatan pariwisata yakni kurangnya sumber pendanaan, kurangnya koordinasi, dan terbatasnya keahlian masyarakat lokal khususnya perempuan.

Kata Kunci: Peran Perempuan, Wisata Pantai, Masyarakat Lokal
Implementasi Protokol Kesehatan Pada Paviliun Indonesia Di Expo 2020 Dubai Uni Emirat Arab
Authors: Sumadiasih Gusti Ayu Istri , Lumanauw Nelsye , Pramesti Dinar Sukma
Published: January 2023

Paviliun Indonesia menjadi negara dengan jumlah kunjungan tertinggi ketiga pada bulan Januari 2022 di expo 2020 Dubai Uni Emirat Arab. Sayangnya, angka kunjungan yang tinggi tersebut, malah menyebabkan ditemukannya kasus positif Covid-19 pada pekerjanya. Penelitian ini bertujuan untuk mengetahui implementasi protokol kesehatan pada penyelenggaraan acara pameran di paviliun Indonesia dan mengetahui faktor yang menyebabkan terjadinya kelalaian dalam implementasi protokol kesehatan di paviliun Indonesia. Penelitian ini menggunakan metode deskriptif kualitatif dengan menggunakan Expo 2020 Covid-19 Guide untuk membedah permasalahan yang meliputi protokol pengunjung memasuki expo, penanganan kasus positif Covid-19, penggunaan penutup wajah dan masker, menjaga jarak dan sanitasi tangan. Pengumpulan data dilakukan melalui wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa protokol kesehatan pengunjung memasuki expo, kasus terduga dan terkonfirmasi, serta prosedur sanitasi tangan terimplementasi dengan baik, namun implementasi penggunaan penutup wajah, masker dan menjaga jarak belum berjalan optimal. Penyebab pelanggaran adalah faktor eksternal yaitu udara panas Dubai, Jumlah Pengunjung Saat High Season yang tidak terkendali, pengunjung Membuat Foto
dan Video, latar belakang negara pengunjung. Faktor internal yang menjadi penyebab pelanggaran yaitu desain jalan paviliun yang menanjak, Security Kurang Fasih Berbahasa Inggris, Tidak Semua Staf Paviliun Menguasai Public Speaking, tidak ada tim khusus protocol Kesehatan. Hasil penelitian ini diharapkan dapat menjadi bahan evaluasi agar kedepannya tidak ditemukannya kasus positif Covid-19 di paviliun Indonesia, maupun paviliun lain di Expo Dubai dan di Expo lainnya.

Kata Kunci: Expo 2020, Paviliun Indonesia, Impementasi, Protokol Kesehatan Expo
Twenty Year review of a Single Surgeon's Experience for craniosynostosis surgery
Authors: De Oliveira Ricardo Santos
Published: January 2023

Introduction: Nonsyndromic craniosynostosis (NC) is more commonly encountered than syndromic cases in pediatric craniofacial surgery. Affected children display characteristic phenotypes according to the suture or sutures involved. This study aims to report a single surgeon experience with surgery for primary craniosynostosis correction.
Methods: A retrospective review was carried out including all cases performed by the same surgeon between 2001 and 2021. The clinical data of 356 patients (371 surgeries) with primary craniosynostosis that have undergone surgery were retrospectively analyzed.
Results: There were 232 (65.1%) males and 124 (34.9%) females, with most of the male preponderance occurring due to the trigonocephaly (86%) and scaphocephaly (84.5%) groups. A female predominance was observed only in brachycephaly group (64.8%). There was a statistically significant male predominance between non-syndromic versus syndromic cases (p=0.0001). The most frequent forms in non-syndromic forms were scaphocephaly in 136 (51.5%), trigonocephaly in 48 (18.1%), anterior plagiocephaly in 47 (17.8%), and brachycephaly in 35 (13.2%). A named syndrome was present in 57 (16%). Genetic syndromes presented more commonly than expected with bilateral synostosis, the Kleeblattschadel deformity, and multiple suture synostosis (p=0.001). Complications were observed in 15 (4.2%). Intraoperative hemorrhage and CSF leakage were the most common ones. Morbidity was significantly associated with monobloc fronto-facial advancement. The mean follow-up was 3.7 years (9 months to 22 years). Morphological results in NC were classified in category I in 210 (70.2%), II in 82 (27.9%), and III in 7 (1.9%) cases for NC.
Conclusions: Non-syndromic craniosynostosis can be corrected with good outcomes and relatively low morbidity and mortality. For syndromic cases a multidisciplinary team is fundamental to archieve satisfactory results.
Morbidity of Parainfluenza 3 Outbreak in Preterm Infants in a Neonatal Unit
Authors: Teo Wan Yee , Rajadurai Victor Samuel , Sriram Bhavani
Published: January 2023

Introduction: Parainfluenza type 3 virus (PIV-3) is an important nosocomial pathogen which causes pneumonia and bronchiolitis in infants. We report an outbreak of PIV-3 respiratory infection which occurred in the neonatal unit of KK Hospital in June 2005. This is the second PIV-3 outbreak in our unit after the first in December 1994. Materials and Methods: The clinical characteristics and outcome of 7 infants tested positive for PIV-3 on nasopharyngeal aspirate in June 2005 were reviewed retrospectively. Results: Seven cases were infected with PIV-3 during this outbreak. The median birthweight of affected infants was 970 g (range, 740 to 2585 g), gestational age was 27 weeks and 4 days (range, 24 to 35 weeks), and postnatal age was 84 days (range, 28 to 250 days). Apnoeas and bradycardias were significant symptoms in 3 infants, 5 infants had progressive respiratory distress while the remaining 2 infants had flu-like illness. Five infants required ventilatory support and there were no deaths. The index case was an infant with chronic lung disease who was on oxygen supplementation and subsequently required ventilatory support with nasal CPAP. Despite implementation of control measures to prevent the spread of infection through early identification with strict cohorting of infected cases, contact tracing/screening, and reinforcement of hand hygiene precautions, the outbreak lasted for 24 days. Conclusion: PIV-3 respiratory infection in preterm infants can present with non-specific symptoms, leading to significant morbidity especially in those with underlying pulmonary pathology. Early recognition of symptoms and diagnosis by physicians, and prompt institution of control measures are necessary to prevent the spread of infection.

Key words: Assisted ventilation, Chronic Lung Disease, Nosocomial respiratory infection, Viral
Evaluation of Data Completeness of the Prostate Cancer Registry after Robotic Radical Prostatectomy
Authors: Huang Honghong , Sim Hong Gee , Chong Tsung Wen , Yuen John SP , Cheng Christopher WS , Lau Weber KO
Published: January 2023

Introduction: This study evaluated the data completeness in the registration of prostate cancer after robotic radical prostatectomy (RRP) in the Urological Cancer Registry at the Singapore General Hospital (SGH), and its compliance to the international standards of US Commission on Cancer (CoC). Materials and Methods: A certified cancer registrar reviewed all RRP cases between June 2003 and July 2008 in the Urological Cancer Registry at SGH. Results: A total of 365 cases were reviewed. The results showed that 351 (96.2%) of RRP patients’ demographic data were captured and 321 (87.9%) of RRP patients were staged. According to the international standards of CoC for an academic institution, the requirement is to capture 100% of all cancer cases and stage at least 90% of them. As for data completeness, 317 (86.7%) of RRP details were captured as compared to the CoC standard requirement of 90%. Conclusions: The existing manual cancer registry does not fully meet the CoC standards. Hence, the registry increased sources of case-finding and used active case-finding. With improvements made to the data collection methodology, the number of prostate cancer cases identified has been increased by 52.1% from 215 in 2007 to 327 in 2009. The registry is expected to be fully compliant with the CoC standard with the recruitment of more full time cancer registrars when a new web-based cancer registry is in full operation.

Key words: Case-finding, Computerised cancer registry, Data quality control, Manual cancer registry
Changing Epidemiology of Enteric Fevers in Singapore
Authors: Ty Albert U , Ang Gary Y , Ang Li Wei , James Lyn , Goh Kee Tai
Published: January 2023

Introduction: We studied the epidemiological trends of enteric fevers (typhoid and paratyphoid fever) in Singapore from 1990 to 2009 and carried out a review of the current prevention and control measures. Materials and Methods: Epidemiological records of all reported enteric fevers maintained by the Communicable Diseases Division, Ministry of Health from 1990 to 2009 were analysed. Results: A total of 2464 laboratory confirmed cases of enteric fevers (1699 cases of typhoid and 765 cases of paratyphoid) were reported. Of these, 75% were imported, mainly from India and Indonesia. There had been a significant fall in the mean annual incidence rate of indigenous enteric fevers from 4.3 per 100,000 population in 1990 to 0.26 per 100,000 population in 2009 (P <0.005) with a corresponding increase in the proportion of imported cases from 71% between 1990 and 1993 to 92% between 2006 and 2009 (P <0.0005). Imported cases involving foreign contract workers increased significantly from 12.8% between 1990 and 1993 to 40.4% between 2006 and 2009 (P <0.0005). Conclusion: Singapore has experienced a marked decline in the incidence of enteric fevers that is now comparable to that of other developed countries. Continued vigilance and proactive measures that address the changing epidemiology of enteric fevers in Singapore are necessary to sustain the milestone achieved in the past 2 decades. Keywords: Imported Cases, Outbreaks, Paratyphoid, Typhoid
Major Workplace Related Accidents in Singapore: A Major Trauma Centre’s Experience
Authors: Ng Zhi Xu , Teo Li Tserng , Go Karen TS , Yeo Yen Teng , Chiu Ming Terk
Published: January 2023

Introduction: Major workplace related accidents pose a significant healthcare resource challenge in Singapore. Materials and Methods: Our study looks at the epidemiology of patients who were admitted for workplace related accidents, in a single institution, with an Injury Severity Score of >9. Results: There were 196 cases of major workplace related accidents admitted between January 2006 and December 2007. The median age of patients admitted was 37 years with a large percentage being males (95.4%) and non-residents (57.1%). The most common ethnic group was Chinese (53.1%) followed by Indians (23.5%). The most common mechanism of injury was fall from height (66.3%) followed by injuries as a result of falling objects at work (21.9%). The percentage of patients who required surgical intervention was 69.9%. Patients admitted for major workplace related accidents had a median length of stay of 5 days in the hospital, a median length of 24 days of medical leave (ML), certifying them unfit for duty and the average cost of stay for each patient was S$11,000. Conclusions: We have a better understanding of the epidemiology and socio-economic impact of workplace related accidents through this study. Workplace related accidents result in significant number of man-days lost from work and monetary cost to employers, medical insurance and the hospital. With an improved understanding, we propose methods to prevent and reduce such accidents in future. A direct consequence of which will be the possible reduction of hospitalisation costs and better allocation of healthcare resources in the future. Key words: Occupation, Hazards, Trauma
A Review on Small-Cell Lung Cancer: Epidemiology, Pathophysiology, Risk Factors, Diagnosis, Clinical Management and Treatment Modalities
Authors:   Department of Pharmacy Practice, College of Pharmacy, National University of Science and Technology, PO Box 620, Postal code 130, Bosher-Muscat, Sultanate of Oman, Alam Md Shamshir
Published: January 2023

Small-cell lung cancer (SCLC) accounts for roughly 15% of all lung malignancies and is distinguished by a high proliferative rate, a proclivity for early metastasis, and a poor prognosis. Exposure to cigarette carcinogens is highly linked to SCLC. Only one-third of individuals have earlier-stage illness that is responsive to possibly curative multimodality treatment at the time of diagnosis. SCLC genomic analysis revealed a high mutation load and widespread chromosomal rearrangements, nearly usually with functional inactivation of the tumour suppressor genes TP53 and RB1. The relative expression of prominent transcriptional regulators has been used to identify subtypes of illness in both human SCLC and murine models, revealing significant intra-tumoural variation. Tumor development, metastasis, and acquired treatment resistance have been linked to aspects of this heterogeneity. Despite the fact that clinical progress in the treatment of SCLC has been notoriously poor, a greater knowledge of the biology of the disease has revealed new vulnerabilities that might be targeted therapeutically. Immune checkpoint blockade, which was recently introduced into the treatment of SCLC patients, has given benefit to patients, with a small fraction of patients experiencing long-term benefits. Strategies to focus tailored therapy to the patients most likely to react and to extend the long-term benefits of successful anti-tumor immunity to a larger number of patients are urgently needed and are now being researched.
Utilization of Areca Nut Extract on the Control of the Golden Snail Pest (Pomacea canaliculata L), Growth and Production of Rice (Oriza sativa L).
Authors:   Agroteknologi Deparment, Agriculture Faculty Almuslim University, Jl. Almuslim Campus No. 1. Al-Muslim University of Bireuen Aceh, Nursayuti Nursayuti , Desparita Naya ,   Agribusiness Deparment, Agriculture Faculty Almuslim University, Jl. Almuslim Campus No. 1. Al-Muslim University of Bireuen Aceh, Elfiana Elfiana ,   Agribusiness Deparment, Agriculture Faculty Almuslim University, Jl. Almuslim Campus No. 1. Al-Muslim University of Bireuen Aceh
Published: January 2023

This study aims to determine the effectiveness, the right dose to control the golden snail pest and the impact of its application on rice production. The study was conducted in Teupin Raya Village, Peusangan Siblah Krueng District from September to November 2022. The design used in this study was a non-factorial Randomized Block Design (RBD) with 7 treatments and 3 replications. The factor tested was areca nut extract with the following treatment: P0: Control, P1: Dose of 100 gr/ha P2: Dose of 150gr/ha P3: Dose of 200 gr/ha P4: Dose of 250 gr/ha P5: Dose of 300 gr/ha P6 : Dose of 350 gr/ha. Parameters observed were golden snail mortality, golden snail mortality, attack intensity, plant height (cm), number of tillers, panicle length (cm), and grain weight (g). The results showed that the treatment of various doses of areca extract on mortality, intensity and yield of rice plants had a very significant effect on plant height at 15 and 45 DAP, number of tillers at 15, 30, 45 DAP, panicle length, and grain weight and not significant effect on plant height at the age of 30 HST. The best treatment for the dose of areca extract on the effectiveness, growth and yield of rice plants was obtained in the P6 treatment at a dose of 350 g/plot.
The Effect of Moment of Truth, Service Quality and Customer Satisfaction on Customer Loyalty
Authors:   Management of Administration, Bina Insani University, Dwita Febrisi , Sudiantini Dian ,   Ecomonic and Business, Bhayangkara University of Jakarta, Agustine Leony ,   Faculty of Agriculture, Tanjungpura University, Sedyoningsih Yeni ,   Management of Administration, Bina Insani University / Management Science, Universitas Negeri Jakarta, Channa Khieng ,   Management, National Polytechnic Institute of Cambodia
Published: January 2023

This study aims to examine a model that evaluates the relationship between the moment of truth and service quality on loyalty through customer satisfaction. This research was conducted at a freight forwarding company, namely JNE Express, Bekasi City, West Java Province, Indonesia. This research was conducted from June to September 2022. The population in this study are customers who have used JNE Express services for an unknown number. This study used a simple random sampling technique and for the sample, 105 respondents participated. The data analysis uses the SEM-PLS technique. The results of this study are that there is a positive relationship between the moment of truth and customer satisfaction, where when the customer is using the delivery service for the first time and has a good impression on the company's services, it can affect perceptions about the ability and use of these services from time to time. The experience of using the service can change the priorities that underlie each customer's main reason. There is a positive influence between Service Quality on customer satisfaction, where when the delivery service company provides maximum service quality, customers will feel and will reuse their services and can even make these customers more loyal to the company. There is a positive influence between customer satisfaction on loyalty, the moment of truth has a positive influence on customer loyalty and service quality has a positive influence on customer loyalty.
Management of massive air leak with persistent pneumothorax and pneumoperitoneum in a 1.2kg preterm neonate: A case report
Authors: Woodun Heerani , Thomas Jeremy , Batra Dushyant , Fraser Nia
Published: January 2023

Background: Pneumothorax is a life-threatening condition with potential iatrogenic causes which can extend to pneumomediastinum and pneumoperitoneum.  Risk factors of spontaneous pneumothorax include prematurity, low birth weight, low APGAR scores, and cesarean-section delivery.
Case Presentation: A 1255 grams preterm boy (Twin-2) was born at 28+3 weeks of gestation by emergency lower segment cesarean section. He showed signs of respiratory distress after uncomplicated endotracheal tube insertion which was required due to apneic episodes during continuous positive airway pressure ventilation. Recurring tube thoracocentesis and high-frequency oscillatory ventilation (HFOV) treated persistent right-sided pneumothorax and nonsurgical pneumoperitoneum, with improvement on day 10, gradual removal of five chest drains by day 19, and extubation on day 24. Transillumination and chest radiography were the main diagnostic investigations. Laryngotracheobronchoscopy on day 16 identified erythema and possible old injury at the carina. He was also treated for hypotension, suspected sepsis, and pulmonary hypertension and was discharged home on day 66.
Conclusion: Identifying pneumothorax promptly is essential to reduce morbidity and mortality. Management is patient-specific and includes needle and tube thoracocentesis and often, mechanical ventilation. Our case demonstrates the challenges of managing a massive air leak in a premature newborn, who with adequate tube thoracocentesis and HFOV, successfully recovered from presumed iatrogenic persistent pneumothorax and pneumoperitoneum.
Tingkah Laku Pembangkang Terhadap Pembentangan Belanjawan di Parlimen Ke-13, 2013-2018
Authors: Asri Amirul Azam , Muhamad Rosyidah
Published: January 2023

Keputusan Pilihan Raya Umum (PRU) ke-14 telah berjaya mengubah landskap politik di Malaysia. PRU14 merupakan pilihan raya yang paling sengit dalam sejarah politik Malaysia. Ianya mencetuskan kejutan besar apabila kerajaan pemerintah iaitu Barisan Nasional (BN) tumbang kepada parti pembangkang Pakatan Harapan (PH). Setelah hampir enam dekad, akhirnya pembangkang PH berjaya menerajui kepimpinan kerajaan Malaysia. Keputusan PRU14 juga menunjukkan peralihan besar sokongan pengundi kepada pembangkang. Beberapa faktor seperti pembangkang yang bersatu dalam menyusun strategi dan kelemahan jentera BN serta beberapa isu salah guna kuasa menjadi punca kekalahan BN pada PRU14. Selain PRU, parlimen juga merupakan indikator penting terhadap pembangunan tadbir urus dan demokrasi Malaysia. Artikel ini akan membincangkan tentang tingkah laku pembangkang yang aktif dan berdaya saing walaupun tidak boleh memainkan peranan sepenuhnya kesan daripada konsep autoritarian yang diamalkan Malaysia. Artikel ini juga akan menganalisis tingkah laku pembangkang dengan merujuk kepada penglibatan dalam pembentangan belanjawan di parlimen ke-13 pada tahun 2013 sehingga 2018. Hal ini kerana, penglibatan pembangkang terhadap pembentang belanjawan negara dilihat signifikan dengan tingkah laku mereka. Kajian ini akan melibatkan tiga parti politik pembangkang yang dominan iaitu Parti Keadilan Rakyat (PKR), Parti Se-Islam Malaysia (PAS) dan Parti Tindakan Demokratik (DAP). Kritikan dan pertanyaan pembangkang mengenai isi kandungan belanjawan negara dilihat relevan bagi penambahbaikan sistem pengurusan kewangan yang dibuat oleh pihak kerajaan.
Prevalence, structure, frequency of complications and outcomes of treatment of rhabdomyolysis in acute exogenous intoxication in a multidisciplinary hospital
Authors: Masolitin Sergey Viktorovich , Protsenko Denis Nikolaevich , Tyurin Igor' Nikolaevich , Mamontova Ol'ga Alekseevna , Magomedov Marat Adessovich , Kim Timur Gennadievich , Marukhov Artem Vladimirovich , Chubchenko Natal'ya Valer'evna
Published: January 2023

Introduction. The prevalence of rhabdomyolysis among people admitted to the hospital due to acute poisoning reaches, according to various foreign sources, from 30 to 40%. In 60% of cases, the development of rhabdomyolysis in adult patients is associated with acute exogenous intoxication. Currently, data on the prevalence, structure and outcomes of treatment of rhabdomyolysis in toxicological patients are mainly presented by the results of foreign clinical and epidemiological studies. The aim is to study the prevalence, structure, frequency of complications and outcomes of treatment of rhabdomyolysis in acute exogenous intoxication in a multidisciplinary hospital. Material and methods. The study included 1,363 patients who were treated from 2017 to 2020 with acute exogenous intoxication. During the study, 98 patients with rhabdomyolysis were selected from the general group. The frequency of poisoning with various toxicants was analyzed, the effects of which led to the development of rhabdomyolysis in acute exogenous intoxication. The incidence of acute kidney injury (AKI) was detected, the outcomes of acute poisoning treatment, the duration of inpatient treatment were determined, and a comparative analysis was carried out between groups of patients with rhabdomyolysis in acute exogenous intoxication (n=98) and without it (n=1265). Results. The prevalence of rhabdomyolysis among patients hospitalized for acute poisoning was 7%. The main reason for the development of rhabdomyolysis was the use of narcotic drugs - 87% of cases. The development of rhabdomyolysis in acute exogenous intoxication in 59.2% of cases is accompanied by the occurrence of AKI, which is significantly higher than among patients without rhabdomyolysis (11.6%). The occurrence of rhabdomyolysis in toxicological patients increases hospital mortality from 6.1 to 10.2%, as well as the duration of inpatient treatment and intensive care by 5.2 and 3.3 days, respectively. Limitations. The study was conducted based on only one multidisciplinary hospital in Moscow in the period from 2017 to 2020. Conclusion. Rhabdomyolysis is a serious complication of acute poisoning, the development of which significantly worsens the outcomes of treatment of patients with a toxicological profile, which requires the development of effective methods for the prevention, diagnosis and treatment of rhabdomyolysis in acute exogenous intoxication.
About combination of positive and negative outcomes of a subchronic exposure of rats to selenium oxide nanoparticles
Authors: Ryabova Yuliya Vladimirovna , Minigalieva Ilzira Amirovna , Privalova Larisa Ivanovna , Sutunkova Marina Petrovna , Sakhautdinova Renata Rashidovna , Klinova Svetlana Vladislavovna , Tazhigulova Anastasiya Valeryevna , Bushueva Tatiana Viktorovna , Makeev Oleg Hermanovich , Katsnelson Boris Aleksandrovich
Published: January 2023

Introduction. Occupational contact with selenium and its compounds, including nanoscale forms, occurs in the glass production, rubber industry, metallurgy (metallurgical processes of copper sludge processing, copper pyrite roasting, manganese, selenium and tellurium production). There are scarce data on the toxicity of selenium nanoparticles. Material and methods. Stable suspensions of nanoparticles or deionized water (control group) were administered to male rats 3 times a week for 6 weeks. A single dose of selenium oxide nanoparticles was 0.2 or 1 or 2 mg/kg of body weight). The condition of the animal organism was assessed with a number of indicators of toxic action at the end of the experiment. The statistical significance of intergroup differences was assessed by Student's t-test. Results. Activity of succinate dehydrogenase in blood lymphocytes reflecting the intensity of energy processes in the organism was decreased. The number of eosinophils in smears-imprints of parenchymal organs and mesenteric lymph nodes increased, indicating the ability of selenium nanooxide to trigger signaling cascades in immunocompetent cells. The number of degenerated cells in the proximal and distal tubules in smears of the kidneys was increased. A tendency to a decrease in all hemodynamics parameters was found. A change in the QT duration, together with an increase in the amplitude of the T wave, probably indicates a violation of the processes of myocardial repolarization. The coefficient of fragmentation of genomic DNA in nucleated blood cells decreased. Limitations. The research was limited to the study of indicators of toxic action in only one study using a limited dose range. Conclusion. An ambiguous effect of selenium oxide nanoparticles on rats was found. Along with negative impact of nanoparticles we have demonstrated, for the first time, some beneficial outcomes, in particular, genome -protective action which is in a striking contrast with the genotoxicity of all elemental and element-oxide nanoparticles previously studied in our laboratory.
Application of OECD QSAR Toolbox software for predicting the mutagenic effects of chemicals
Authors: Khamidulina Khalidya Khizbulaevna , Tarasova Elena Vladimirovna , Lastovetskiy Mikhail Leonidovich
Published: January 2023

Introduction. The introduction of new chemical products to the market requires a preliminary assessment of their danger to human health and the environment, including specific and long-term effects. Taking into account the medical and social significance of the consequences of exposure to chemicals with a mutagenic effect on the body, the study of genotoxicity / mutagenicity seems to be extremely relevant. In order to reduce the number of experiments performed on animals, calculation methods are being actively introduced into toxicological practice, in particular OECD QSAR Toolbox software. Therefore, the aim of our research was to study the possibility of using the OECD QSAR Toolbox software to predict the mutagenic effects of chemicals. Material and methods. OECD QSAR Toolbox software version 4.4.1., OECD guidelines on the assessment of the mutagenic effect. Results and discussion. We have developed the “Guidelines for predicting the mutagenic effects of chemicals”, which includes a detailed description and work with the program when predicting the mutagenic effects of chemicals. Based on the analysis of OECD documents on the assessment of the mutagenic potential of chemicals, seven most widely used tests were selected, which allow evaluating the effect on various test objects in the presence / absence of metabolic activation systems. For methods, indicators were selected that must be set to start the calculation in the QSAR Toolbox software. The most suitable databases and profilers were also indentified. Conclusion. Forecasting using the OECD QSAR Toolbox software is a screening method that involves performing several calculations using the results of various experimental studies for analogs, and subsequent expert interpretation of the data obtained.
Mortalities of southern right whales (Eubalaena australis) and related anthropogenic factors in South African waters, 1999–2019
Authors: Vermeulen Els , Jouve Elise , Best Peter , Cliff Geremy , Dicken Matt , Kotze Deon , McCue Steven , Meÿer Mike , Seakamela Mduduzi , Thompson Greg , Thornton Meredith , Wilkinson Chris
Published: January 2023

The southern right whale (Eubalaena australis; SRW) population in South Africa’s coastal waters has experienced marked changes since 2009, including altered feeding and migration behaviour, and decreased calving success. At the same time, anthropogenic activities in the area have increased. Based on this, an update on SRW mortalities and related anthropogenic factors is warranted. Building on the published information of Best et al. (2001a), data were collated on all SRW mortalities as well as non‐fatal ship‐strikes and entanglements along the South African coast between 1999 and 2019. A total of 97 SRW mortalities were recorded, including three that did not result in a stranding, of which the majority were classified as calves of the year. Most of these occurred on the Western Cape coast between the months of July to November, coinciding with the seasonal presence of the species in South African coastal waters. Eleven of these mortalities could be attributed to ship‐strikes whereas three mortalities related to entanglements. A total of 98 non‐fatal incidents, including 16 ship‐strikes and 82 entanglements with SRWs, were recorded in South Africa between 1999 and 2019. Ship‐strikes occurred mainly around the area of Cape Town harbour. Entanglements occurred mainly in rock‐lobster gear and bather‐protection nets in the Western Cape and KwaZulu‐Natal provinces respectively, although the latter did not occur between 2015–2019 attributable to the replacement of over 70% of the nets by drumlines, and the removal of the remaining nets during whale season. In general, the incidence of SRW mortalities and entanglements decreased post‐2007, coinciding with the decreased presence of SRWs along the South African coast. Available data show a relatively low rate of fatal entanglements and ship‐strikes, although this may be underestimated due to the opportunistic nature of the collated data. In view of the population growth rate and the increased anthropogenic activities in South African coastal waters, continued and improved monitoring (e.g. through a more systematic reporting system) of these incidents is crucial to ensure accurate knowledge‐based management decisions in the future. Possible mitigation measures aimed at reducing anthropogenic interactions are mooted.
Роль развивающих игр в обучении младших школьников
Authors: Каримова Нилуфар
Published: January 2023

В статье раскрыта важность формирования навыков и выявлены способы развития младших школьников в игровой деятельности. Выявлены возможности игровой деятельности в формировании навыков у младших школьников.
Changes in vitamin D and calcium-phosphorus metabolism in patients with severe acute pancreatitis
Authors: Kolosovych Ihor , Hanol Ihor , Bystrytska Maryna , Uzun Halil
Published: January 2023

Objective: The problem of predicting the course of acute pancreatitis and early diagnosis of its complications remains unresolved. This study aimed to determine changes in vitamin D and calcium-phosphorus metabolism in patients with severe acute pancreatitis.

Material and Methods: There were examined 72 people divided into two groups as healthy persons (comparison group) - males and females without pathology of the gastrointestinal tract and any other conditions or diseases that could affect the state of calcium-phosphorus metabolism (n= 36) and patients with acute pancreatitis (main group, n= 36). In addition, in order to determine the prognostic criteria for the severity of the disease, patients in the main group were divided into two subgroups. The first subgroup included patients with severe disease (n= 18), the second (n= 18) - with mild and moderate disease.

Results: Serum calcium value was lower in patients with severe acute pancreatitis comparison to healthy persons: 2.18 (2.12; 2.34) vs 2.36 (2.31; 2.43) mmol/L (p< 0.0001), and the decrease of calcium levels was associated with an increase in the severity of acute pancreatitis. Therefore, hypocalcemia can be considered a reliable predictor of the severity of the disease. In patients with acute pancreatitis, the level of vitamin D was significantly low than in the healthy persons and was 13.8 (9.03; 21.34) and 28.4 (21.8; 32.3) ng/mL, respectively (p< 0.0001).

Conclusion: For patients with acute pancreatitis, serum vitamin D levels≤ 13.28 ng/mL can be considered as a significant predictor of severe disease (sensitivity 83.3%, specificity 94.4%) regardless of calcium level.
What has changed in the last 20 years in the postoperative specimen findings of the papillary thyroid cancer cases? A retrospective analysis
Authors: Bakar Burak , Taşar Pınar , Kırdak Turkay , Kılıçturgay Sadık
Published: January 2023

Objective: In this study, it was aimed to investigate the changes in surgical approaches and histopathological evaluation of the tumor according to years of patients who were operated on with the diagnosis of thyroid papillary cancer (PTC) in our center in the last 20 years.

Material and Methods: The records of the cases who underwent thyroidectomy in our department were divided into four groups of five years each and analyzed retrospectively. Demographic characteristics, surgical procedures, presence of chronic lymphocytic thyroiditis, histopathological features of tumour and hospital stay of the cases in the groups were evaluated. Based on tumor size, PTCs were classified into five subgroups. PTCs of 10 (mm) or less were accepted as papillary thyroid microcarcinoma (PTMC).

Results: There was a significant increase in PTC and multifocal tumors in the groups over the years (p< 0.001). There was a significant increase between the groups in the presence of chronic lymphocytic thyroiditis (p< 0.001). In contrast, the total number of metastatic lymph nodes (p= 0.486) and the largest metastatic lymph node size were similar between the groups (p> 0.999). In our study, it was observed that there was a significant increase over the years in both the total/near-total thyroidectomy cases and the number of cases with a postoperative hospital stay of one day (p< 0.001).

Conclusion: In the present study, it was found that papillary cancer sizes decreased gradually and the frequency of papillary microcarcinoma increased gradually in last 20 years. Also, a significant increase was detected in the rates of total/near-total thyroidectomy and lateral neck dissection over the years.
Validation of the adapted clavien dindo in trauma (ACDiT) scale to grade management related complications at a level I trauma center
Authors: Banerjee Niladri , Bagaria Dinesh , Agarwal Harshit , Kumar Katiyar Anand , Kumar Subodh , Sagar Sushma , Mishra Biplab , Gupta Amit
Published: January 2023

Objective: Complications during trauma management are the main factor responsible for the overall increase in treatment cost. There are very few grading systems to measure the burden of complications in trauma patients. A prospective study was conducted using the Adapted Clavien Dindo in Trauma (ACDiT) scale, with the primary aim of validating it at our center. As a secondary aim, it was also wanted to measure the mortality burden among our admitted patients.

Material and Methods: The study was conducted at a dedicated trauma center. All patients with acute injuries, who were admitted, were included. An initial treatment plan was made within 24 hours of admission. Any deviation from this was recorded and graded according to the ACDiT. The grading was correlated with hospital-free days and ICU-free days within 30 days.

Results: A total of 505 patients were included in this study, with a mean age of 31 years. The most common mechanism of injury was road traffic injury, with a median ISS and NISS of 13 and 14, respectively. Two hundred and forty-eight out of 505 patients had some grade of complication as determined by the ACDiT scale. Hospital-free days (13.5 vs. 25; p< 0.001) were significantly lower in patients with complications than those without complications, and so were ICU-free days (29 vs. 30; p< 0.001). Significant differences were also observed when comparing mean hospital free and ICU free days across various ACDiT grades. Overall mortality of the population was 8.3 %, the majority of whom were hypotensive on arrival and required ICU care.

Conclusion: We successfully validated the ACDiT scale at our center. We recommend using this scale to objectively measure in-hospital complications and improve trauma management quality. ACDiT scale should be one of the data points in any trauma database/registry.
Selective approach to arterial ligation in radical sigmoid colon cancer surgery with D3 lymph node dissection: A multicenter comparative study
Authors: Efetov Sergey , Zubayraeva Albina , Kayaalp Cüneyt , Minenkova Alisa , Bağ Yusuf , Alekberzade Aftandil , Tsarkov Petr
Published: January 2023

Objective: Radical surgery for sigmoid colon cancer is commonly performed with complete mesocolic excision (CME) and apical lymph node dissection, reached by central vascular ligation (CVL) of the inferior mesenteric artery (IMA) and associated extended left colon resection. However, IMA branches can be ligated selectively according to tumor location with D3 lymph node dissection (LND), economic segmental colon resection and tumorspecific mesocolon excision (TSME) if IMA is skeletonized. This study aimed to compare left hemicolectomy with CME and CVL and segmental colon resection with selective vascular ligation (SVL) and D3 LND.

Material and Methods: Patients (n= 217) treated with D3 LND for adenocarcinoma of the sigmoid colon between January 2013 and January 2020 were included in the study. The approach to vessel ligation, colon resection and mesocolon excision was based on tumor location in the study group, while in the comparison group, left hemicolectomy with routine CVL was performed. Survival rates were estimated as the primary endpoints of the study. Long- and short-term surgery-related outcomes were evaluated as the secondary endpoints of the study.

Results: The studied approach to the IMA branch ligation was associated with a statistically significant decrease in intraoperative complication rates (2 vs 4, p= 0.024), operative procedure length (225.56 ± 80.356 vs 330.69 ± 175.488, p< 0.001), and severe postoperative morbidity (6.2% vs 19.1%, p= 0.017). Meanwhile, the number of examined lymph nodes significantly increased (35.67 vs 26.69 per specimen, p< 0.001). There were no statistically significant differences in survival rates.

Conclusion: Selective IMA branch ligation and TSME resulted in better intraoperative and postoperative outcomes with no difference in survival rates.
Bangladeshi Currency Identification and Fraudulence Detection Using Deep Learning and Feature Extraction
Authors: Siddiki Marjuk Ahmed , Hossain Md Naim , Akhter Khadija , Rahman Md. Riazur
Published: January 2023

There are persistent rumors about counterfeit money all across the world. There is a massive loop of producing counterfeit currency that is developing alongside technology. Counterfeit currency production has gotten easier and more advanced day by day, so the detection process has gotten more challenging. Utilizing a variety of user-friendly counterfeit detection tools or software is the only method to stop fraud. Many people still do not have access to these softwares or tools for detecting fakes. Therefore, some of these programs or tools are not accurate, dependable, and free. This paper describes a potential software solution for detecting fake Bangladeshi banknotes. The most important thing is that it is totally free of cost and usable by all average people. The primary purpose of this software is to identify different currencies and determine whether it is real or fake. In this paper, Convolutional Neural Network (CNN) and FLANN-based Matcher with the Scale-Invariant Feature Transform (SIFT) algorithms have been implemented in the deep learning process to recognize the currency and determine whether it is genuine or counterfeit, to make the entire process functional. 1, 2, 5, 10, 20, 50, 100, 200, 1000, and 5000 notes from Bangladesh have been used in this research. One of the most suitable methods to detect fake currency is color-changeable holographic thread, The Portrait of Bangabandhu Sheikh Mujibur Rahman and “Bangladesh Bank (in Bengali)” written on the level of intaglio ink, printed hidden below the middle of the note, “Amount in Bengali” at the right bottom of the note, Some parallel lines or objects of intaglio ink, and color changeable ink OVI and SPARK. Additionally, this procedure makes it possible to quickly identify fake money. To make the system quick and easy for everyone, the entire system has been developed into a mobile based and as well as a web-based application.
Basaltoids of the ostrogorsk complex: geology, age, geochemistry, geodynamics (Western Sikhote-Alin)
Authors: NIGAI ELENA
Published: January 2023

This review-analytical article presents the most important geological, geochronological and geochemical characteristics of the basaltoids of the Ostrogorsk complex. Some Early Miocene datings of the age of Ostrogorsk basaltoids on the State Geological Map of the third generation (sheet M-53) were not considered due to methodological considerations and, for greater objectivity, they are given by the author in this article. The basaltoids of the Ostrogorsk complex, like the alkaline basalts of the Ayakit complex, belong to intraplate rift basalts. The spectra of rare earth and rare elements in both complexes are very similar. The composition of basaltoids of the Ostrogorsk and Ayakit complexes is close to the composition of oceanic island basalts and recycled components, which suggests that they have a single mantle-crustal source.
Diamond-bearing lithosphere of the Siberian platform (based on geophysical data). Tectonic zonation
Authors: MYASNIKOV FYODOR
Published: January 2023

In the first part of the article, we show structural relationships of prospective areas and perform tectonic zonation of the Siberian Platform (SP) using potential fields, application of the structural method, fractal analysis and multidimensional statistical methods. The formal classification of the trend components of the prospective areas of the SP into 7 taxa made it possible to establish on a quantitative basis the special status of the Anabar Province (AN), the central part of the SP, as a geological space with signs of minimal tectonic divisibility of the lithosphere. This is essential for the preservation of diamonds and the formation of deposits
PERCEPÇÃO DE PROFESSORES DE EDUCAÇÃO INFANTIL E ENSINO FUNDAMENTAL SOBRE A ATUAÇÃO DO PSICÓLOGO NA EDUCAÇÃO SEXUAL DENTRO DO AMBIENTE ESCOLAR
Authors: Pereira Elaine Alves , Hommerding Ana Paula Guaitaneli , Calça Luiza Martins , Mello Rafaela Zago de
Published: January 2023

Este estudo teve como intuito realizar uma pesquisa com os professores de educação infantil e ensino fundamental, das escolas públicas, de um município no Oeste do Paraná, com o objetivo de identificar a postura do professor frente ao tema sexualidade com crianças, analisar quais os empecilhos que os professores enfrentam ao abordar o tema e investigar quanto à necessidade de um psicólogo contribuindo na educação sexual infantil. A escolha da temática, foi investigar a atuação do psicólogo nas escolas na rede pública do município de Foz do Iguaçu. O referencial teórico da presente pesquisa foi estruturado em dois tópicos, a saber: sexualidade dentro do ambiente escolar e a importância do psicólogo dentro da escola. O método utilizado na pesquisa foi levantamento de dados bibliográficos e pesquisa quali-quantitativa, sendo que a coleta de dados foi realizada através de um formulário online pela plataforma Google Forms, elaborado pelas pesquisadoras, contendo ao total 14 perguntas. Participaram da pesquisa 26 educadores entre 20 e 60 anos de idade que estavam no mínimo um ano efetivos em sala de aula da Educação Infantil e Ensino Fundamental de escolas municipais. Constatou-se que a maioria dos educadores é a favor do psicólogo no ambiente escolar. Constatado também que os educadores encontram dificuldades para abordar o tema sexualidade, sendo que a maioria dos entrevistados declararam não ter recebido nenhuma orientação ou capacitação sobre o tema, do qual precisa ser abordado de forma coesa, em todos os aspectos sociais.