bluuebunny/crossref_metadata_2025 huggingface dataset:
Parent Perceptions of an Early Childhood System’s Community Efforts: A Qualitative Analysis
Authors: Bentley Brandie , Hoang Tuyet Mai Ha , Arroyo Sugg Gloria , Jenkins Karen V. , Reinhart Crystal A. , Pouw Leah , Accove Ana Maria , Tabb Karen M.
Published: June 2023

Understanding how parents, and other primary caregivers, perceive and experience early childhood programs and services is essential for identifying family-centered facilitators and barriers to service utilization. Therefore, this paper aims to explore parent knowledge of and experiences with community efforts of an early childhood system in Illinois: the All Our Kids Early Childhood Networks (AOK Networks). Our research team conducted focus group interviews with 20 parents across four Illinois counties. A semi-structured interview guide was used to examine parent perceptions of an early childhood system’s community efforts in promoting the health and well-being of children aged from birth to five. Thematic network analysis was used to analyze all focus group data. Parents indicated three salient themes, including: (1) comprehensive information sharing practices, (2) diverse service engagement, and (3) barriers to service access. Overall, parents reported general satisfaction with the quality of available services and provided feedback regarding identified areas of need to increase the accessibility and utilization of local services. Engaging parents as partners is essential to the effective implementation of family-centered early childhood services. Families are the experts of their lived experiences, and incorporating their voices in program development and evaluation efforts works to increase positive child and family outcomes.
‘Compressed Baby Head’: A New ‘Abusive Head Trauma’ Entity?
Authors: Macorano Enrica , Gentile Mattia , Stellacci Giandomenico , Manzionna Mariano , Mele Federica , Calvano Mariagrazia , Leonardelli Mirko , Duma Stefano , De Gabriele Giovanni , Cristalli Alessandro , Minella Raffaella , Di Fazio Aldo , Introna Francesco
Published: June 2023

Background: Child abuse represents an important issue in the medico-legal and social context. In the last few decades, various aspects and mechanisms have been identified in child abuse case studies; however, constant research is needed in the field. With this paper, the authors will present a case of a new entity of Abusive Head Trauma that has come to the attention of medico-legal experts. Discussion: The trauma analysis performed on the cranio-encephalic district of the baby revealed quite peculiar lesions that led the authors to exclude that the injuries had been solely caused by violent shaking of the baby’s head, as suggested by Shaken Baby Syndrome. Instead, the authors hypothesised that another lesion mechanism had been added to this one, namely latero-lateral cranial compression. The comprehensive and exhaustive analysis of the case led the authors to present a new possible entity in child abuse trauma, namely ‘Compressed Baby Head’. Conclusions: To the best of our knowledge, in the current literature, no similar clinical cases have ever been described. Thus, the case’s uniqueness deserves to be brought to the attention of experts and the entire scientific community, as well as medical personnel, paediatricians, and reanimators. These professional figures are the first individuals who may encounter complex clinical cases such as the one presented in this paper; thus, they need to know how to properly manage the case and ensure protection for the abused infants and children.
Reduced Hippocampal Volumes in Children with History of Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia
Authors: Pfister Katie M. , Stoyell Sally M. , Miller Zachary R. , Hunt Ruskin H. , Zorn Elizabeth P. , Thomas Kathleen M.
Published: June 2023

Hypoxic ischemic encephalopathy (HIE) remains a significant cause of disability despite treatment with therapeutic hypothermia (TH). Many survive with more subtle deficits that affect daily functioning and school performance. We have previously shown an early indication of hippocampal changes in infants with HIE despite TH. The aim of this study was to evaluate the hippocampal volume via MRI and memory function at 5 years of age. A cohort of children followed from birth returned for a 5-year follow-up (n = 10 HIE treated with TH, n = 8 healthy controls). The children underwent brain MRI and neurodevelopmental testing to assess their brain volume, general development, and memory function. Children with HIE had smaller hippocampal volumes than the controls despite no differences in the total brain volume (p = 0.02). Children with HIE generally scored within the average range on developmental testing. Though there was no difference in the memory scores between these groups, there was a positive within-group correlation between the hippocampal volume and memory scores in children with HIE (sentence recall r = 0.66, p = 0.038). There was no relationship between newborn memory function and 5-year hippocampal size. Children with HIE treated with TH experienced significant and lasting changes to the hippocampus despite improvements in survival and severe disability. Future studies should target diminishing injury to the hippocampus to improve overall outcomes.
Expressed Beliefs about the Cause of Pain in a Pediatric Population: A Qualitative Study
Authors: Menés Fernández Laura , Salvat Isabel , Adillón Cristina
Published: June 2023

(1) Background: The aims of this study are to explore what beliefs children and adolescents manifest about the cause of the pain they describe, to compare whether there are differences between beliefs by age and the persistence of pain, and to relate the explanations of the cause of pain with current scientific evidence. (2) Methods: a cross-sectional qualitative study was used. The primary endpoint of the study was obtaining explanations of the cause of pain recorded by means of an open-ended question. The participants were school-age children attending a charted school in the province of Barcelona. (3) Results: The children and adolescents proposed a diverse range of explanations for the cause of pain that they reported in their responses. The most frequent explanation for the cause of pain were pathologies and injuries (45.95%), ergonomic issues (22.60%) and psychological issues (15.95%). (4) Conclusions: There is a lot of variety in the explanations that young people give about the cause of their pain in schoolchildren aged between 10 and 16 years old. There exists a high prevalence of explanations non-associated with tissue damage (ENAD) concerning the causes of pain described. It is necessary that future health prevention programs dedicated to early ages consider which beliefs about the cause of pain are the most frequent in the pediatric population.
Secure Firmware Update: Challenges and Solutions
Authors: Catuogno Luigi , Galdi Clemente
Published: June 2023

The pervasiveness of IoT and embedded devices allows the deployment of services that were unthinkable only few years ago. Such devices are typically small, run unattended, possibly on batteries and need to have a low cost of production. As all software systems, this type of devices need to be updated for different reasons, e.g., introducing new features, improving/correcting existing functionalities or fixing security flaws. At the same time, because of their low-complexity, standard software distribution platforms and techniques cannot be used to update the software. In this paper we review the current limitations posed to software distribution systems for embedded/IoT devices, consider challenges that the researchers in this area have been identifying and propose the corresponding solutions.
Biomarkers for Predicting Anti-Programmed Cell Death-1 Antibody Treatment Effects in Head and Neck Cancer
Authors: Tanaka Katsunori , Hirakawa Hitoshi , Suzuki Mikio , Higa Teruyuki , Agena Shinya , Hasegawa Narumi , Kawakami Junko , Toyama Masatomo , Higa Tomoyo , Kinjyo Hidetoshi , Kise Norimoto , Kondo Shunsuke , Maeda Hiroyuki , Ikegami Taro
Published: June 2023

In recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC), survival outcomes are significantly better in patients who receive anti-programmed cell death-1 (PD-1) monoclonal antibody therapy than in those who receive standard therapy. However, there is no established biomarker that can predict the anti-PD-1 antibody treatment effect and immune-related adverse events (irAEs) in these patients. This study investigated the inflammatory and nutritional status in 42 patients with R/M-HNSCC and programmed cell death ligand-1 (PD-L1) polymorphisms (rs4143815 and rs2282055) in 35 of the 42 patients. The 1- and 2-year overall survival was 59.5% and 28.6%, respectively; the 1- and 2-year first progression-free survival was 19.0% and 9.5%, respectively, and the respective second progression-free survival was 50% and 27.8%. Performance status and inflammatory and nutritional status (assessed by the geriatric nutritional risk index, modified Glasgow prognostic score, and prognostic nutritional index) were identified as significant indicators of survival outcomes in multivariate analysis. Patients with ancestral alleles in PD-L1 polymorphisms had less frequent irAEs. Performance status and inflammatory and nutritional status before treatment were closely related to survival outcomes after PD-1 therapy. These indicators can be calculated using routine laboratory data. PD-L1 polymorphisms may be biomarkers for predicting irAEs in patients receiving anti-PD-1 therapy.
Health Workers’ Knowledge and Attitude towards Monkeypox in Southwestern Saudi Arabia: A Cross-Sectional Study
Authors: Sobaikhi Nasser H. , Alshahrani Najim Z. , Hazazi Rakan S. , Al-Musawa Hafiz I. , Jarram Raed E. , Alabah Amjad E. , Haqawi Nawaf F. , Munhish Fadi A. , Shajeri Mohammed A. , Matari Mohammed H. , Salami Riyadh M. , Hobani Alhassan H. , Yahya Najla A. , Alhazmi Abdulaziz H.
Published: June 2023

Background: Monkeypox outbreaks in non-endemic countries emphasize the importance of being prepared to prevent its progression to a pandemic. To effectively control monkeypox, healthcare providers must have sufficient knowledge and good attitudes and practices to limit its spread. We initiated this project to assess the factors associated with health workers’ knowledge and attitude toward monkeypox in southwestern Saudi Arabia. Methods: We included 398 eligible health workers working at various health facilities. Data was collected using an online survey, and participants had an opportunity to consent. We conducted descriptive statistics for all variables and used chi-square statistics, t-test, and multivariate analysis to establish the association between health workers’ demographic characteristics and knowledge of monkeypox disease. Results: The mean age was 30.93 ± 8.25 years for the included participants, and most of them were between 22 and 29 years, male, single, nurses, working in government hospitals, and had worked for at least five years. The chi-square and t-test showed that the participants’ knowledge level was significantly related to age, marital status, job title, and medical practice. Most of the participants had low knowledge and good attitudes toward monkeypox prevention measures. Multivariate analysis showed that higher knowledge was associated with younger age after controlling all other significant bivariate relationships between knowledge and demographics. Conclusions: This study found low knowledge levels and high good attitude levels of monkeypox among the participants. As such, there is a need to support health workers in understanding monkeypox epidemiology, prevention, and treatment. Therefore, Saudi Arabia will be making significant strides to being well prepared and ready to handle future monkeypox outbreaks.
Fuzzy Adaptive Command-Filter Control of Incommensurate Fractional-Order Nonlinear Systems
Authors: Gong Dianjun , Wang Yong
Published: June 2023

This paper focuses on the command-filter control of nonstrict-feedback incommensurate fractional-order systems. We utilized fuzzy systems to approximate nonlinear systems, and designed an adaptive update law to estimate the approximation errors. To overcome the dimension explosion phenomenon in the backstepping process, we designed a fractional-order filter and applied the command filter control technique. The closed-loop system was semiglobally stable, and the tracking error converged to a small neighbourhood of equilibrium points under the proposed control approach. Lastly, the validity of the developed controller is verified with simulation examples.
Ability and Trait Emotional Intelligence: Do They Contribute to the Explanation of Prosocial Behaviour?
Authors: Babić Čikeš Ana , Tomašić Humer Jasmina
Published: June 2023

Previous research on ability emotional intelligence (EI) has shown that EI positively contributes to different positive life outcomes. However, the role of EI abilities in prosocial behaviour (PSB) has not been sufficiently investigated. The aim of this study is to investigate the relationships between EI abilities measured by tests and self-reports, empathy and PSB in the student population. A total of N = 331 university students completed a sociodemographic questionnaire, two EI tests, and self-report measures of EI, cognitive empathy, emotional reactivity and PSB. Of all EI measures, only self-reports correlated with PSB. Cognitive and emotional empathy were also related to PSB. Hierarchical regression analysis showed that self-assessed EI, cognitive empathy and emotional reactivity were predictors of PSB. Cognitive empathy and emotional reactivity also mediated the relationship between self-assessed EI and PSB. The results showed that for the prediction of PSB, it is important how a person evaluates his emotional abilities, and not what the actual level of these abilities is. Furthermore, people with higher self-estimated EI behave prosocially more often because they experience empathy to a greater extent, both cognitively and emotionally.
Eco-Efficiency as a Decision Support Tool to Compare Renewable Energy Systems
Authors: Huber Dominik , Martinez Alonso Ander , Lavigne Philippot Maeva , Messagie Maarten
Published: June 2023

Even though eco-efficiency (EE) is already applied to various energy systems, so far, no study investigates in detail the hourly, marginal and seasonal impacts of a decentralized energy system. This study assesses the hourly EE of the Research Park Zellik (RPZ), located in the Brussels metropolitan area for 2022 composed of photovoltaic installations, wind turbines and batteries. A cradle-to-grave life cycle assessment (LCA) to identify the carbon footprint (CF) and a levelized cost of electricity (LCOE) calculation is conducted. An existing design optimization framework is applied to the RPZ. Consumption data are obtained from smart meters of five consumers at the RPZ on a one-hour time resolution for 2022 and upscaled based on the annual consumption of the RPZ. As the EE is presented as the sum of the CF and the LCOE, a lower EE corresponds to an economically and environmentally preferable energy system. In a comparative framework, the developed method is applied to two different case studies, namely, (i) to an energy system in Vega de Valcerce in Spain and (ii) to an energy system in Bèli Bartoka in Poland. The average EE of the RPZ energy system in 2022 is 0.15 per kWh, while the average EE of the Polish and Spanish energy systems are 1.48 and 0.36 per kWh, respectively. When analyzing four selected weeks, both the LCOE and CF of the RPZ energy system are driven by the consumption of the Belgian electricity grid mix. In contrast, due to the very low LCOE and CF of the renewable energy sources, in particular wind turbines, the RPZ energy system’s EE benefits and lies below the EE of the Belgium electricity grid mix.
Applying AHP-IFNs-DEMATEL in Establishing a Supplier Selection Model: A Case Study of Offshore Wind Power Companies in Taiwan
Authors: Hsu Min-Chih , Lee Hsuan-Shih
Published: June 2023

Offshore wind power has emerged as a relatively new industry in Taiwan in recent years. Energy companies strive to achieve maximum production capacity and product lifespan at the lowest cost. Therefore, selecting the most suitable supplier is a primary objective. This research has identified 23 evaluation criteria for supplier selection based on a literature review. By employing the Analytic Hierarchy Process (AHP), individual weights were assigned to each criterion. Subsequently, the Intuitionistic Fuzzy Numbers Decision Making Trial and Evaluation Laboratory (IFNs-DEMATEL) method was used to analyze the 11 criteria with weights higher than the average, thereby exploring the overall causal relationships. Additionally, by utilizing the four quadrants of the Influential Relation Map (IRM), offshore wind power suppliers can adjust resource allocation to maximize benefits. The findings of this research can provide recommendations for offshore wind power shipping companies in their supplier selection and resource allocation. Furthermore, offshore wind power suppliers can adjust their development criteria and enhance their competitiveness based on the criterion weights and the analysis derived from the Influential Relation Map.
Performance Assessment of a Grid-Connected Two-Stage Bidirectional Converter for a Combined PV–Battery Energy Storage System
Authors: Hasan Md. Mahamudul , Jaman Shahid , Geury Thomas , Hegazy Omar
Published: June 2023

This paper presents a comprehensive performance assessment of a two-stage power electronic (PE) converter for interfacing the grid of a lithium-ion battery energy storage system (Li-BESS) for building-integrated PV (BIPV) applications. A performance assessment of the control system was conducted for the two-stage PE interface with a common DC-link, which consisted of a bi-directional boost converter with a cascaded PI controller and an AC/DC converter with proportional-integral (PI) and proportional-resonant (PR) controllers. The assessment covered loss analysis and useful lifetime estimation for the 10 kW PE interface with a wide-bandgap SiC power MOSFET at different loads for both the charging and discharging modes of a 50 kWh lithium-ion battery system. Additionally, a performance comparison of various switching frequencies was performed. It was observed that the system was stable up to a switching frequency of 30 kHz, and that increasing the switching frequency improved the responsiveness of the converter by decreasing the settling time; however, there were diminishing returns at higher switching frequencies. To obtain a proper balance between responsiveness and lower loss, a switching frequency of 10 kHz was selected.
High-Precision Acquisition Method of Position Signal of Permanent Magnet Direct Drive Servo Motor at Low Speed
Authors: Zhang Deli , Dong Zhaopeng , Bu Feifei , Gu Zijie , Guo Zitao
Published: June 2023

This paper studies a method for high-precision acquisition of position signals for permanent magnet direct drive servo motors at low speed. First of all, the problem of poor position feedback accuracy and sensor feedback delay in the low-speed operation of the permanent magnet direct drive servo motor is analyzed. Secondly, through analysis and simulation, it is found that the interpolation method can play a certain role in compensating the rotor position signal. However, when the speed is close to 0, the output signal of the sensor will fluctuate in a short time, which will affect the speed control accuracy. Therefore, this paper uses the observer method to achieve high-precision acquisition of the position signal of the permanent magnet direct drive servo motor at low speed. The observer method adopts the idea of combining the system model and closed-loop control. Additionally, it makes full use of the parameter information of the motor system. The control performance of the motor can be better guaranteed through the design of the observer parameters and the accuracy of the rotor position estimation result has been greatly improved. Finally, an experimental platform for permanent magnet direct drive servo motors is built, and the rotor position signal acquisition method based on the observer method is verified to have good performance through simulation and experiments. Not only the accuracy of the rotor position estimation result is improved, but also the motor control performance is improved, realizing the stable operation of the permanent magnet direct drive servo motor at low speed.
Carbon-Neutral Steel Production and Its Impact on the Economies of China, Japan, and Korea: A Simulation with E3ME-FTT:Steel
Authors: Vercoulen Pim , Lee Soocheol , Han Xu , Zhang Wendan , Cho Yongsung , Pang Jun
Published: June 2023

The iron and steel industry is a large emitter of CO2 globally. This is especially true for the iron and steel industries in China, Japan, and Korea due to their production volumes and the prevalence of carbon-based steel production. With few low-carbon and commercially available alternatives, the iron and steel industry is truly a hard-to-abate sector. Each of the countries of interest have committed to a net-zero future involving the mitigation of emissions from steel production. However, few studies have investigated the means by which to achieve decarbonization beyond the inclusion of price signalling policies (e.g., carbon tax or emission trading schemes). Here, we use E3ME-FTT:Steel to simulate technology diffusion in the ISI under several policy environments and we investigate the likely impacts on the wider economy. The results show that penalizing carbon intensive processes can incentivize a transition towards scrap recycling, but it is relatively unsuccessful in aiding the uptake of low carbon primary steelmaking. A combination of support and penalizing policies can achieve deep decarbonisation (>80% emission reduction compared with the baseline). Mitigating the emissions in the iron and steel industry can lead to economic benefits in terms of GDP (China: +0.8%; Japan: +1.3%; Korea: +0.1%), and employment (Japan: +0.7%; Korea: +0.3%) with China, where job losses in the coal sector would negate job gains elsewhere, as the exception.
Magnetic Pole Equivalence and Performance Analyses of Multi-Layer Flux-Barrier Combined-Pole Permanent-Magnet Synchronous Machines Used for Electric Vehicles
Authors: Wang Weinan , Fu Lingfang , Wang Shuo , Wei Jian , Liu Yiqi , Zhu Liangkuan , Ban Mingfei
Published: June 2023

Multi-layer flux-barrier combined-pole permanent-magnet synchronous machines (MLFB-CP-PMSMs) are especially suitable for machines used in electrical vehicles (EVs), as they represent a tradeoff between electromagnetic performance and the consumption of high-priced rare-earth permanent magnets (PM). In this paper, magnetic pole equivalence and performance analyses of the MLFB-CP-PMSM are investigated. Firstly, three types of PM arrangements of combined poles are introduced, namely, parallel, series and series–parallel. Then, the magnetic circuit model and magnetic pole equivalence principle of MLFB-CP-PMSMs with different PM arrangements are analyzed. After that, the accuracy of the equivalence method is studied by comparing the machine electromagnetic performance before and after equivalence. Finally, the MLFB-CP-PMSM’s performance, including the loss, efficiency and electromagnetic torque, is analyzed. The results prove that the MLFB-CP-PMSM has the advantage of high efficiency, and the equivalence method can retain precision when the MLFB-CP-PMSM armature reaction degree varies.
More Children Means More Tumours? We Can Do More to Protect the Health of Our Kids—A Call for a New Epidemiology That Can Change the World
Authors: Piscitelli Prisco , Miani Alessandro , Greco Enrico , Distante Alessandro , Schittulli Francesco , Civino Adele
Published: June 2023

In encyclopaedic dictionaries published until 1955, the word “tumour” was defined as an “occupational disease suffered by the workers of chemical industries”, thus referring to a very specific cause [...]
2D Semantic Segmentation: Recent Developments and Future Directions
Authors: Guo Yu , Nie Guigen , Gao Wenliang , Liao Mi
Published: June 2023

Semantic segmentation is a critical task in computer vision that aims to assign each pixel in an image a corresponding label on the basis of its semantic content. This task is commonly referred to as dense labeling because it requires pixel-level classification of the image. The research area of semantic segmentation is vast and has achieved critical advances in recent years. Deep learning architectures in particular have shown remarkable performance in generating high-level, hierarchical, and semantic features from images. Among these architectures, convolutional neural networks have been widely used to address semantic segmentation problems. This work aims to review and analyze recent technological developments in image semantic segmentation. It provides an overview of traditional and deep-learning-based approaches and analyzes their structural characteristics, strengths, and limitations. Specifically, it focuses on technical developments in deep-learning-based 2D semantic segmentation methods proposed over the past decade and discusses current challenges in semantic segmentation. The future development direction of semantic segmentation and the potential research areas that need further exploration are also examined.
Temperature Effects on Recruitment and Individual Growth of Two Antagonistic Fish Species, Perch Perca fluviatilis and Roach Rutilus rutilus, from a Climate Change Perspective
Authors: Linløkken Arne N.
Published: June 2023

Perch (Perca fluviatilis) in four boreal lakes and sympatric roach (Rutilis rutilis) in two of these lakes were studied by means of gill net sampling, and age and growth were analyzed to explore whether summer temperature affects recruitment and individual growth of the two species differently. Water temperature logging in the lakes showed a highly significant correlation with air temperature. Year-class strength of the perch was significantly positively affected by the summer air temperature, whereas the temperature effect was non-significant for the roach. There was a significant negative effect of year-class strength of one-year-old perch on roach year-class strength in one lake. ln one of the allopatric perch populations, the year-class strength correlation with temperature failed after biomass removal, probably because fishing affected the age structure. July–August air temperature had a significantly positive effect on individual growth rates of two- to five-year-old perch, whereas the effect on roach growth was less clear. The inclination of perch to predate its competitor, roach, as well as conspecifics, as well as accelerated individual growth, were shown to occur more frequently in years with abundant 1+ perch, i.e., the summer after the rise of a strong year-class. Climate warming may potentially favor perch recruitment and growth.
Growth Retardation, Oxidative Stress, Immunosuppression, and Inflammatory Disturbances Induced by Herbicide Exposure of Catfish, Clarias gariepinus, and the Alleviation Effect of Dietary Wormwood, Artemisia cina
Authors: El-Houseiny Walaa , Anter Reham G. A. , Arisha Ahmed H. , Mansour Abdallah Tageldein , Safhi Fatmah Ahmed , Alwutayd Khairiah Mubarak , Elshopakey Gehad E. , Abd El-Hakim Yasmina M. , Mohamed Engy M. M.
Published: June 2023

The present study evaluated the impact of chronic herbicide (oxyfluorfen; OXY) exposure on catfish, Clarias gariepinus, in terms of growth, hematobiochemical parameters, immune response, antioxidant- and immune-related gene expression, and resistance to monogenean parasites, Quadriacanthus aegypticus. In addition, the protective role of Wormwood, Artemisia cina (AC) against OXY exposure through diet inclusion was also analyzed. The catfish fingerlings were exposed to OXY (1.16 mg/L) for 60 days and fed diets without AC supplementation (control) and with 5% AC supplementation. The results demonstrated that exposure to OXY stunted growth; decreased survival, erythrograms and leukograms, serum protein, and acetylcholinesterase; and negatively altered the antioxidant status. On the contrary, AC supplementation significantly reduced OXY’s negative impacts on growth and hematological, biochemical, and antioxidant balance. In addition, exposure to OXY markedly increased levels of biomarkers of hepatorenal damage, stress indicators, and DNA damage, which were alleviated with AC supplementation. OXY exposure induced immunosuppression manifested by a decrease in lysozyme activities, complement c3, nitric oxide levels, and phagocytic activity. Furthermore, exposure to OXY negatively regulated the expression of immune-antioxidant genes (CAT, GPX1, SOD1, GST, and TGF-Β1). However, it upregulated the expression of CYP1a, IL-1β, and TNF-α in the liver, anterior kidney, and intestine of C. gariepinus. Meanwhile, the addition of AC to the OXY-exposed fish diets notably restored immune components and remedied the altered immune-related gene expressions. Likewise, the AC supplementation significantly alleviated the OXY-induced reduction in the fish survival rate after Q. aegypticus challenge. Accordingly, AC dietary supplementation in catfish diets could alleviate the negative impact of exposure to OXY on growth performance, physiological status, and some immune-antioxidant-related gene expression.
Current Methods and Advances in the Immunotherapy Treatment of Non-Ovarian Gynaecological Cancers
Authors: Adeleke Sola , Gao Yujia , Okoli Somto , Choi Sunyoung , Ding Hao , Galante Joao R. , Mikropoulos Christos
Published: June 2023

Endometrial cancer (EC) and cervical cancer (CC) are common malignancies in women in clinical practice. More uncommon non-ovarian malignancies, such as vulval cancer (VC), are also becoming more prevalent in women of all ages. Currently, there are few comprehensive reviews on the management of these conditions, despite the recent advances in the use of immunotherapy in the management of other forms of cancer. The treatment modalities for EC, CC and VC vary; however, platinum-based chemotherapy, surgical resection and radiotherapy are the main forms of treatment. In more advanced or recurrent disease, there is a limited number of efficacious treatments, with many clinicians relying on adjuvant chemotherapy despite the increased rationale for the use of immunotherapy. With the development of the novel adoptive T-cell therapy, intra-tumoural oncolytic viral therapy and cancer vaccines, the landscape of gynaecological cancer management is changing, and it is likely that treatment efficacy and outcomes will improve dramatically. This review aims to summarise the current management of endometrial, cervical and vulval cancer and to evaluate the novel therapies under development, as well as the future of the management of non-ovarian gynaecological malignancies.
Impact of Water and Nutrient Supplementation on Yield of Prairie Plantings of Juneberry Amelanchier alnifolia Nutt., Cultivar and Windbreak Plantings
Authors: Hartman Kerry , Alahakoon Dilmini , Fennell Anne
Published: June 2023

Amelanchier alnifolia Nutt. (Juneberry, Saskatoon berry or Serviceberry) fruit historically played an important role as fresh or dried food and as a medicinal staple in the Mandan, Hidatsa, and Arikara Tribal Nations. Natural Juneberry stands were lost during the creation of Sakakawea Reservoir on the Fort Berthold Reservation. Reintroduction of the Juneberry is important to the tribal communities. Therefore, the impact of water and fertilizer supplementation was explored in two mature Juneberry cultivar (Honeywood, Martin, and Smokey) plantings and a seedling windbreak planting. Yield was examined in three consecutive years with three treatments: (1) natural conditions (control; no additional water or fertilizer); (2) irrigation during flowering and fruit ripening period (irrigated); and (3) fertilization plus irrigation during flowering and fruit ripening period (fertilized). Yield varied from 5 to 258 g/0.03 m−3 across locations, treatments, and years. There was no difference in yield across locations and treatments in year one. Yield was greater in the second year than first year, but not different across locations or treatments. The fertilized treatment showed increased yield in the third year in contrast to irrigated treatment across locations. New plantings can be established more economically using seedling material and the yield increased if watered and fertilized during fruit development.
Quantitative Perturbation Analysis of Plant Factory LED Heat Dissipation on Crop Microclimate
Authors: Yu Haibo , Yu Haiye , Zhang Bo , Chen Meichen , Liu Yucheng , Sui Yuanyuan
Published: June 2023

Regulating plant factories is crucial for optimal plant growth and yield. Although LEDs (light-emitting diode) are called cold light sources, more than 80% of the heat is still emitted into the surrounding environment. In high-density vertical agricultural facilities, the crop canopy is positioned close to the light source to maximize light absorption and promote plant growth. LED heat dissipation can cause disturbances in the microclimate of crop canopies, which can lead to tip burn disease in plant crops and result in economic losses for plant factories. CFD (computational fluid dynamics) is used as the main technical tool to simulate and optimize the environment of agricultural facilities. This study utilized Star-ccm+ to simulate the microclimate of plant factories under different light treatments. Uniformity coefficient UI and disturbance coefficient θ were proposed to quantitatively analyze LED heat dissipation’s impact on microclimate. In the T5 treatment group, which had a PPFD of 350 μmol/m2·s in the growth zone and 250 μmol/m2·s in the seedling zone, the relative humidity (RH), airflow, and temperature uniformity coefficients UI were 0.6111, 0.3259, and 0.5354, respectively, with corresponding disturbance coefficients θ of 0.0932, 0.1636, and 0.1533. This study clarifies the degree of perturbation caused by LED heat dissipation on microclimate, providing a theoretical basis for regulating plant factory light and promoting sustainability.
Taxonogenomic Analysis of Marine-Derived Streptomyces sp. N11-50 and the Profile of NRPS and PKS Gene Clusters
Authors: Komaki Hisayuki , Igarashi Yasuhiro , Tamura Tomohiko
Published: June 2023

Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin and cyclo(Phe-Leu). This study aimed to reveal the potential to synthesize diverse nonribosomal peptide and polyketide compounds as the other secondary metabolites different from DKP after clarifying the taxonomic position. Strain N11-50 was identified as Streptomyces albus, as it showed 100% 16S rRNA gene sequence similarities and 95.5% DNA–DNA relatedness to S. albus NBRC 13014T. We annotated the nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) gene clusters in the genome. Consequently, five NRPS, one hybrid PKS/NRPS, five type-I PKS and one type-II PKS gene clusters were observed, of which we predicted the products through bioinformatic analysis. These gene clusters were well conserved in already whole-genome sequence (WGS)-published strains belonging to S. albus. On the other hand, our taxonogenomic analysis revealed that three WGS-published S. albus strains were not S. albus. Two of the three should be classified as Streptomyces albidoflavus, and the remaining one was likely a new genomospecies. After reclassifying these appropriately, we demonstrated species-specific profiles of the NRPS and PKS gene clusters with little strain-level diversities.
Spatiotemporal Variability in Total Dissolved Solids and Total Suspended Solids along the Colorado River
Authors: Adjovu Godson Ebenezer , Stephen Haroon , Ahmad Sajjad
Published: June 2023

The Colorado River is a principal source of water for 40 million people and farmlands in seven states in the western US and the Republic of Mexico. The river has been under intense pressure from the effects of climate change and anthropogenic activities associated with population growth leading to elevated total dissolved solid (TDS) and total suspended solid (TSS) concentrations. Elevated TDS- and TSS-related issues in the basin have a direct negative impact on the water usage and the ecological health of aquatic organisms. This study, therefore, analyzed the spatiotemporal variability in the TDS and TSS concentrations along the river. Results from our analysis show that TDS concentration was significantly higher in the Upper Colorado River Basin while the Lower Colorado River Basin shows a generally high level of TSSs. We found that the activities in these two basins are distinctive and may be a factor in these variations. Results from the Kruskal–Wallis significance test show there are statistically significant differences in TDSs and TSSs from month to month, season to season, and year to year. These significant variations are largely due to seasonal rises in consumptive use, agriculture practices, snowmelts runoffs, and evaporate rates exacerbated by increased temperature in the summer months. The findings from this study will aid in understanding the river’s water quality, detecting the sources and hotspots of pollutions to the river, and guiding legislative actions. The knowledge obtained forms a strong basis for management and conservation efforts and consequently helps to reduce the economic damage caused by these water quality parameters including the over USD 300 million associated with TDS damages.
Burnout and Brownout in Intensive Care Physicians in the Era of COVID-19: A Qualitative Study
Authors: Baillat Léa , Vayre Emilie , Préau Marie , Guérin Claude
Published: June 2023

The health crisis has had a strong impact on intensive care units. The objective of this study was to investigate the experience of resuscitation physicians during the COVID-19 health crisis to understand the associated determinants of quality of life, burnout, and brownout. This qualitative, longitudinal study covered two periods (T1, February 2021, and T2, May 2021). The data were collected in individual semi-directed interviews with 17 intensive care physicians (ICPs) (T1). Nine of the latter also participated in a second interview (T2). The data were examined using grounded theory analysis. We identified a multiplication of burnout and brownout indicators and factors already known in intensive care. In addition, burnout and brownout indicators and factors specific to the COVID-19 crisis were added. The evolution of professional practices has disrupted the professional identity, the meaning of work, and the boundaries between private and professional life, leading to a brownout and blur-out syndrome. The added value of our study lies in identifying the positive effects of the crisis in the professional domain. Our study revealed indicators and factors of burnout and brownout associated with the crisis among ICPs. Finally, it highlights the beneficial effects of the COVID-19 crisis on work.
Ecogeographic Drivers of the Spatial Spread of Highly Pathogenic Avian Influenza Outbreaks in Europe and the United States, 2016–Early 2022
Authors: Gass Jonathon D. , Hill Nichola J. , Damodaran Lambodhar , Naumova Elena N. , Nutter Felicia B. , Runstadler Jonathan A.
Published: June 2023

H5Nx highly pathogenic avian influenza (HPAI) viruses of clade 2.3.4.4 have caused outbreaks in Europe among wild and domestic birds since 2016 and were introduced to North America via wild migratory birds in December 2021. We examined the spatiotemporal extent of HPAI viruses across continents and characterized ecological and environmental predictors of virus spread between geographic regions by constructing a Bayesian phylodynamic generalized linear model (phylodynamic-GLM). The findings demonstrate localized epidemics of H5Nx throughout Europe in the first several years of the epizootic, followed by a singular branching point where H5N1 viruses were introduced to North America, likely via stopover locations throughout the North Atlantic. Once in the United States (US), H5Nx viruses spread at a greater rate between US-based regions as compared to prior spread in Europe. We established that geographic proximity is a predictor of virus spread between regions, implying that intercontinental transport across the Atlantic Ocean is relatively rare. An increase in mean ambient temperature over time was predictive of reduced H5Nx virus spread, which may reflect the effect of climate change on declines in host species abundance, decreased persistence of the virus in the environment, or changes in migratory patterns due to ecological alterations. Our data provide new knowledge about the spread and directionality of H5Nx virus dispersal in Europe and the US during an actively evolving intercontinental outbreak, including predictors of virus movement between regions, which will contribute to surveillance and mitigation strategies as the outbreak unfolds, and in future instances of uncontained avian spread of HPAI viruses.
Physical Education: At the Centre of Physical Activity Promotion in Schools
Authors: Cale Lorraine
Published: June 2023

Whilst recognising and advocating for the role and importance of schools and whole school approaches to the promotion of physical activity in schools, this paper argues that physical education (PE) should be at the centre of and driving schools’ efforts to promote physical activity. Various reasons are given for this, with these broadly centring on the unique goal, nature, and responsibilities of the subject with respect to promoting physically active lifestyles and health-related learning. Furthermore, there have been positive strides in recent years to support this endeavour and that serve to highlight, strengthen, and reinforce the focus and responsibility of PE in the promotion of physical activity. In light of these, it is suggested that it is a pivotal time for PE. Equally, it is accepted that PE faces some longstanding challenges that are hindering and raise questions concerning the subject’s physical activity promotion efforts. Despite this, it is contended that these should not be unsurmountable, and more recent developments should also help the subject to realise its physical activity promoting potential moving forwards. In particular, the critical importance of high-quality PE that has young people at the core is highlighted. It is concluded that it is both time and timely for the PE profession to be bold, have confidence, and grasp these opportunities and ensure that high-quality PE is central to the explicit planning and co-ordination of meaningful, coherent, relevant, and sustainable physical activity opportunities for young people in schools.
Health Disparities and Comparison of Psychiatric Medication Use before and after the COVID-19 Pandemic Lockdown among General Practitioner Practices in the North East of England
Authors: Yu Ge , Tang Eugene Y. H. , Fu Yu
Published: June 2023

Background: Psychiatric medications play a vital role in the management of mental health disorders. However, the COVID-19 pandemic and subsequent lockdown limited access to primary care services, leading to an increase in remote assessment and treatment options to maintain social distancing. This study aimed to investigate the impact of the COVID-19 pandemic lockdown on the use of psychiatric medication in primary care settings. Methods: We conducted a retrospective claims-based analysis of anonymized monthly aggregate practice-level data on anxiolytics and hypnotics use from 322 general practitioner (GP) practices in the North East of England, where health disparities are known to be higher. Participants were all residents who took anxiolytics and hypnotics from primary care facilities for two financial years, from 2019/20 to 2020/21. The primary outcome was the volume of Anxiolytics and Hypnotics used as the standardized, average daily quantities (ADQs) per 1000 patients. Based on the OpenPrescribing database, a random-effect model was applied to quantify the change in the level and trend of anxiolytics and hypnotics use after the UK national lockdown in March 2020. Practice characteristics extracted from the Fingertips data were assessed for their association with a reduction in medication use following the lockdown. Results: This study in the North East of England found that GP practices in higher health disparate regions had a lower workload than those in less health disparate areas, potentially due to disparities in healthcare utilization and socioeconomic status. Patients in the region reported higher levels of satisfaction with healthcare services compared to the England average, but there were differences between patients living in higher versus less health disparate areas. The study highlights the need for targeted interventions to address health disparities, particularly in higher health disparate areas. The study also found that psychiatric medication use was significantly more common in residents living in higher health disparate areas. Daily anxiolytics and hypnotics use decreased by 14 items per 1000 patients between the financial years 2019/20 and 2020/21. A further nine items per 1000 decreased for higher health disparate areas during the UK national lockdown. Conclusions: People during the COVID-19 lockdown were associated with an increased risk of unmet psychiatric medication demand, especially for higher health disparate areas that had low-socioeconomic status.
Unemployment and Job Search Behavior among People with Disabilities during the First Year of the COVID-19 Pandemic in Germany
Authors: Paul Karsten , Hollederer Alfons
Published: June 2023

Not much is known about how the COVID-19 pandemic affected the labor market experiences of people with disabilities. Since they constitute a generally disadvantaged group in the labor market, it is important to scrutinize whether their position has worsened during these difficult times and how they reacted with regard to their job search behavior. We therefore used data for the year 2020 from a large German panel (Panel Arbeitsmarkt und Soziale Sicherung, PASS), in order to scrutinize the prevalence of unemployment among people with disabilities (N = 739) during the first year of the COVID-19 pandemic. The factors that affected their unemployment status were also analyzed. The study found that people with legally recognized disabilities were more often unemployed than non-disabled people, even when controlling for possible confounding factors such as age, gender, or education. This effect was significant for severe disabilities and marginally significant for minor disabilities. Additionally, the type of disability affected the probability of being unemployed, with cardiovascular diseases, mental illnesses, and musculoskeletal disorders carrying a higher risk. In terms of job-seeking behavior, unemployed people with disabilities reported using some job search methods more frequently than their non-disabled counterparts. However, the intensity of the job search did not differ significantly between the two groups. Further differences were found when analyzing the reasons for abstinence from searching for a job, with unemployed people with disabilities primarily citing health-related factors (with a frequency of over 90%). In summary, health played a pivotal role in determining disabled people’s labor market experiences during the COVID-19 pandemic.