bluuebunny/crossref_metadata_2025 huggingface dataset:
Endoscope-controlled extended supraorbital keyhole approach through a modified eyebrow incision for a large dural-based solitary fibrous tumor of the frontal convexity: A technical note
Authors: Azab Waleed , Najibullah Mustafa , Waheed Ghada
Published: April 2022

Background:

The extended supraorbital approach through a modified eyebrow incision is a minimally invasive approach that has been recently described. It entails a lateral extension of the skin incision beyond the lateral end of the eyebrow and allows exposure of the proximal sylvian fissure with a superior degree of surgical freedom in the middle fossa and the parasellar region. In this technical note, we describe an endoscope-controlled extended supraorbital keyhole approach with modified eyebrow incision for excision of a large dural-based solitary fibrous tumor of the left frontal convexity.

Methods:

An endoscope-controlled extended supraorbital keyhole approach with modified eyebrow incision was performed to excise a large extra-axial mass attached to the dura of the left frontal convexity and extends from the superior temporal line up to the midline in a 34-year-old male patient presented with 1-year history of headache, dizziness, and blurred vision.

Results:

The patient had an uneventful postoperative course with gross total excision of the lesion and satisfying cosmetic appearance. Histopathological examination revealed a Grade 1 solitary fibrous tumor.

Conclusion:

We demonstrated the feasibility of the endoscope-controlled extended supraorbital keyhole approach through a modified eyebrow incision for excision of tumors that abut the inner table of the frontal calvarial bone, extend highly above the skull base level, or extend medially reaching the midline. The approach is very versatile and allows a great exposure for a category of lesions deemed not perfectly suitable for the classic supraorbital keyhole approach.
Truncal dystonia with isolated middle cerebral artery ischemia: A case report of revascularization therapy for dystonia
Authors: Matsumoto Shinichi , Yamamoto Yuki , Fujita Koji , Miyamoto Ryosuke , Koizumi Hidetaka , Tateishi Akihiro , Yamada Naoaki , Izumi Yuishin
Published: April 2022

Background:

Dystonia is a rare movement disorder with some cases being difficult to treat. Although dystonia can occur as a symptom of moyamoya disease, few studies have reported truncal dystonia occurring with middle cerebral artery (MCA) stenosis. Here, we report a case of truncal dystonia with MCA occlusion.

Case Description:

The patient was a 48-year-old female clerical worker who lived alone. An abnormal cervical posture initially appeared 7 years before (right flexion). Symptoms improved with medication and botulinum toxin injection. Five years before this report, her symptoms worsened, so the dose of oral medication was increased and botulinum treatment was performed, but the symptoms did not improve. The patient showed decreased cerebral blood flow (CBF) in the cortical areas but not in the basal ganglia. We performed superficial temporal artery-MCA bypass surgery because we believed that the dystonia was due to right MCA stenosis. The patient’s symptoms improved immediately after surgery, except for her mild cervical backbend. Seven months after the surgery, the patient’s involuntary movements showed further improvement, and symptoms have not worsened even after 2 years.

Conclusion:

Revascularization therapy improved CBF and truncal dystonia and could be a viable treatment option for dystonia with ischemia in the MCA region. Extensive cerebral ischemia can result in cortical inhibition loss or over-adapted cerebral plasticity and cause dystonia. Revascularization therapy may be useful for patients with dystonia and decreased CBF in the MCA region.
Remote bifrontal epidural hematoma following hemispheric glioma resection. A rare life-threatening postoperative complication
Authors: Akhaddar Ali , Bellasri Salah , Belhadj Ayoub , Baallal Hassan
Published: April 2022

Background:

Postoperative acute epidural hematoma (EDH) is a well-known serious complication that usually occurs at the operated site after cranial surgery. However, epidural bleeding, distant from the site of the previous craniotomy, is relatively rare and may sometimes cause significant neurological morbidity or even mortality. We report such a case.

Case Description:

A 35-year-old woman, previously healthy, was operated on for a left temporo-parieto-fronto-insular anaplastic astrocytoma. Between 2 and 4 h after the surgery, the patient had trouble waking-up following the general anesthesia. Emergent computed tomography (CT) scan revealed an acute bifrontal EDH away from the initial surgical field. The patient underwent an immediate reoperation, a decompressive bifrontal craniotomy, and the evacuation of the hematoma. Despite the neurologic improvement, she died 24 days after the surgery due to severe sepsis caused by pulmonary infection with pseudomonas aeruginosa.

Conclusion:

The pathophysiology of postoperative remote EDH is poorly understood, although various hypotheses have been suggested including the loss of tamponade effect, the vasomotor mechanisms, and the coagulopathy. As seen in the present case report, we suspected that the intensive use of perioperative mannitol may also promote this complication. In the early postoperative period, every patient with neurological deterioration should have a rapid cranial CT-scan because early detection and removal of postoperative acute EDH can be life-saving.
Periosteum-induced ossification effect in skull defect through interleukin-8 and NF-κB pathway: An experimental study with Oryctolagus cuniculus rabbits
Authors: Apriawan Tedy , Widjiati Widjiati , Utomo Dwikora Novembri , Fauzi Asra Al , Subagio Eko Agus , Utomo Budi , Islam Andi Asadul , Bajamal Abdul Hafid , Sudiana I. Ketut
Published: April 2022

Background:

The purpose of this study was to analyze the response of inflammatory cytokines interleukin-8 (IL-8) and NF-κB to the closure of skull defect with periosteum as a scaffolding material in bone healing used after surgery.

Methods:

Thirty Oryctolagus cuniculus rabbits underwent a craniotomy to create a 20 mm diameter round defect in the parietal bones. The parietal bones were returned to its place and stabilized by an internal plate fixation. The defects were either left empty or implanted with periosteum. At 6 weeks, the specimens were euthanized and examined.

Results:

Histological examination showed a more well-developed formation of woven bone in the periosteum group. Immunohistochemical examinations showed that the use of periosteum in the closure of skull defects reduced the NF-κB and IL-8 response which affected the ossification process.

Conclusion:

The experiment showed that the use of periosteum was linked with IL-8 and NF-κB downregulation toward ossification effects at any point throughout the trial. Periosteum usage might be beneficial as a scaffolding material in bone healing for autograft cranioplasty in animal model and could be applied to clinical practice.
Intracranial ancient schwannoma originating from vestibular nerve: A case report and review of the literature
Authors: Tsuchiya Takahiro , Miyawaki Satoru , Shinya Yuki , Teranishi Yu , Tomioka Arisa , Yamazawa Sho , Shin Masahito , Saito Nobuhito
Published: April 2022

Background:

Ancient schwannoma (AS) is a subtype of schwannoma with degenerative features, which often progresses slowly over a long period of time. Intracranial AS is a rare benign tumor and there are no detailed reports of AS originating from the vestibular nerve.

Case Description:

Herein, we present the case of a patient with the right vestibular schwannoma with multiple meningiomas and review three previous cases of intracranial AS. Near-total resection was performed for vestibular schwannoma and the pathological findings were AS (World Health Organization Grade I). Five months postoperatively, gamma knife radiosurgery was performed for a recurrent lesion of the right vestibular schwannoma in the internal auditory meatus. Although AS is known to be a benign pathology, there are cases of rapid growth and early recurrence, as the one presented here. The high Ki-67 index (up to 5%) and the presence of cysts may be related to the rapid progression of intracranial AS.

Conclusion:

Therefore, careful follow-up is necessary even if adequate removal is achieved. In addition to pathological studies, the genetic background of intracranial AS warrants future investigations. Further accumulation of cases is necessary to clarify the clinical features of intracranial AS.
Implications and limitations of magnetic resonance perfusion imaging with 1.5-Tesla pulsed arterial spin labeling in detecting ictal hyperperfusion during non-convulsive status epileptics
Authors: Goto Katsuhiro , Shimogawa Takafumi , Mukae Nobutaka , Shono Tadahisa , Fujiki Fujio , Tanaka Atsuo , Sakata Ayumi , Shigeto Hiroshi , Yoshimoto Koji , Morioka Takato
Published: April 2022

Background:

Recent our reports showed that 3-T pseudocontinuous arterial spin labeling (3-T pCASL) magnetic resonance perfusion imaging with dual post labeling delay (PLD) of 1.5 and 2.5 s clearly demonstrated the hemodynamics of ictal hyperperfusion associated with non-convulsive status epilepticus (NCSE). We aimed to examine the utility of 1.5-T pulsed arterial spin labeling (1.5-T PASL), which is more widely available for daily clinical use, for detecting ictal hyperperfusion.

Methods:

We retrospectively analyzed the findings of 1.5-T PASL with dual PLD of 1.5 s and 2.0 s in six patients and compared the findings with ictal electroencephalographic (EEG) findings.

Results:

In patients 1 and 2, we observed the repeated occurrence of ictal discharges (RID) on EEG. In patient 1, with PLDs of 1.5 s and 2.0 s, ictal ASL hyperperfusion was observed at the site that matched the RID localization. In patient 2, the RID amplitude was extremely low, with no ictal ASL hyperperfusion. In patient 3 with lateralized periodic discharges (LPD), we observed ictal ASL hyperperfusion at the site of maximal LPD amplitude, which was apparent at a PLD of 2.0 s but not 1.5 sec. Among three patients with rhythmic delta activity (RDA) of frequencies <2.5 Hz (Patients 4–6), we observed obvious and slight increases in ASL signals in patients 4 and 5 with NCSE, respectively. However, there was no apparent change in ASL signals in patient 6 with possible NCSE.

Conclusion:

The detection of ictal hyperperfusion on 1.5-T PASL might depend on the electrophysiological intensity of the epileptic ictus, which seemed to be more prominent on 1.5-T PASL than on 3-T pCASL. The 1.5-T PASL with dual PLDs showed the hemodynamics of ictal hyperperfusion in patients with RID and LPD. However, it may not be visualized in patients with extremely low amplitude RID or RDA (frequencies <2.5 Hz).
Implementasi Keputusan Bupati Rokan Hulu Nomor 250 Tahun 2011 Tentang Pembentukan Tim Sekretariat Tim Intensifikasi Pajak Bumi Dan Bangunan Di Kabupaten Rokan Hulu
Authors: Armiati  , Nurman
Published: April 2022

Sesuai dengan Undang-Undang Nomor 12 Tahun 1994 tentang Pajak Bumi dan Bangunan, dimana pada pasal 3 ayat (2) Pajak Bumi dan Bangunan adalah Pajak Negara yang sebagian besar penerimaannya merupakan pendapatan daerah dan berdasarkan Keputusan Menteri Keuangan Republik Indonesia Nomor 1007/KMK.04/1985 Tentang Pelimpahan Kewenangan Penagihan Pajak Bumi dan Bangunan kepada Gubernur Kepala Daerah Tingkat I dan /atau Bupati / Walikota Kepala Daerah Tingkat II. Permasalahan dirumuskan dalam pertanyaan penelitian: “Bagaimana Implementasi Keputusan Bupati Rokan Hulu Nomor 250 Tahun 2011 Tentang Pembentukan Tim dan Sekretariat Tim Intensifikasi  Pajak Bumi Dan Bangunan?”Penulis mencoba menjawabnya melalui penelitian dengan menggunakan metode deskriptif kualitatif. Dari hasil penelitian dapat disimpulkan bahwa Dalam implementasi Pembentukan  Tim dan Sekretariat Tim Intensifikasi  Pajak Bumi Dan Bangunan ini dapat disimpulkan: 1) Ukuran dan tujuan kebijakan belum dapat tercapai sesuai dengan target, 2) Sumber-sumber Kebijakan sudah berjalan sesuai dengan ketentuan peraturan perundang-undangan yang berlaku, 3) Aspek Ciri-ciri sifat badan/instansi pelaksana belum secara baik terlaksana dimana KPP Pratama Bangkinang belum mampu memberikan pelayanan khususnya terhadap pemuktahiran data pajak, 4) Komunikasi antar KPP Pratama Bangkinang dan aparat pemerintah kabupaten Rokan Hulu tidak berjalan dengan baik hal ini disebabkan luasnya wilayah kerja KPP Pratama Bangkinang. 5) Sikap aparat pelaksana yang harus ditingkatkan dengan mengadakan pelatihan dan pemotivasian agar setiap  staf dapat melaksanakan  kegiatan secara optimal sesuai  dengan peran, tugas  dan tanggungjawabnya. 6) Tingginya pengaruh aspek sosial, ekonomi dan politik dalam implementassinya.. Pelaksanaan sistem perpajakan ini dalam implementasinya belum terlaksana secara optimal.
Effects of the COVID-19 pandemic on active life behavior of elementary school students in West Java
Authors: Tarigan Beltasar , Hidayat Teten
Published: April 2022

The COVID-19 pandemic is transforming human activities, including learning at school. The study aims to analyze the direct effects of the COVID-19 pandemic on the active lifestyle of elementary school students across West Java. In addition, the specific aim of this study is to obtain empirical evidence on active life behavior. The research method in this study is a quantitative descriptive method. The population consists of elementary school students from across West Java and a random sample of 1,867 students from each district. The sampling technique uses a simple random sampling technique. The results shows that the active lifestyle behavior of students during the Covid-19 pandemic is at most distributed in the low category of up to 1,088 people (58%) and before the Covid-19 pandemic the largest distribution is in the moderate category up to 1147 people (61%). These data show that the COVID-19 pandemic is affecting the decline in student active living from the moderate category to the low category.
Magnetic Exchange Interactions in Binuclear and Tetranuclear Iron (III) Complexes Described by Spin-Flip DFT and Heisenberg Effective Hamiltonians
Authors: Kotaru Saikiran , Kähler Sven , Alessio Maristella , Krylov Anna I.
Published: April 2022

Low-energy spectra of single-molecule magnets (SMMs) are often described by Heisenberg Hamiltonians. Within this formalism, exchange interactions between magnetic centers determine the ground-state multiplicity and energy separation between the ground and excited states. In this contribution, we extract exchange coupling constants (J) for a set of iron (III) binuclear and tetranuclear complexes from all-electron calculations using non-collinear spin-flip time-dependent density functional theory (NC-SF-TDDFT). For 12 binuclear complexes with J-values ranging from -6 to -132 cm−1, our benchmark calculations using the short-range hybrid ωPBEh functional and 6-31G(d,p) basis set agree well with the experimentally derived values (mean absolute error of 4.7 cm−1). For the tetranuclear SMMs, the computed J constants are within 6 cm−1 from the experimentally derived values. We explore the range of applicability of the Heisenberg model by analyzing bonding patterns in these Fe(III) complexes using natural orbitals (NO), their occupations, and the number of effectively unpaired electrons. The results illustrate the efficiency of the spin-flip protocol for computing the exchange couplings and the utility of the NO analysis in assessing the validity of effective spin Hamiltonians.
Improving force field accuracy by training against condensed phase mixture properties
Authors: Boothroyd Simon , Madin Owen , Mobley David , Wang Lee-Ping , Chodera John , Shirts Michael
Published: April 2022

Developing a sufficiently accurate classical force field representation of molecules is key to realizing the full potential of molecular simulation as a route to gaining fundamental insight into a broad spectrum of chemical and biological phenomena. This is only possible, however, if the many complex interactions between molecules of different species in the system are accurately captured by the model. Historically, the intermolecular van der Waals (vdW) interactions have primarily been trained against densities and enthalpies of vaporization of pure (single-component) systems, with occasional usage of hydration free energies. In this study, we demonstrate how including physical property data of binary mixtures can better inform these parameters, encoding more information about the underlying physics of the system in complex chemical mixtures. To demonstrate this, we re-train a select number of the Lennard-Jones parameters describing the vdW interactions of the OpenFF 1.0.0 (Parsley) fixed charge force field against training sets composed of densities and enthalpies of mixing for binary liquid mixtures as well as densities and enthalpies of vaporization of pure liquid systems, and assess the performance of each of these combinations. We show that retraining against the mixture data almost universally improves the force field's ability to reproduce both pure and mixture properties, reducing some systematic errors that exist when training vdW interactions against properties of pure systems only.
Ligand-Metal Cooperation Enables C–C Activation Cross-Coupling Reactivity of Cyclopropyl Ketones
Authors: Gilbert Michael , Trenerry Michael , Longley Victoria , Berry John , Weix Daniel
Published: April 2022

Activation of C–C bonds has the potential to revolutionize how molecules are made by altering the carbon skeleton and enabling new synthetic routes. Stereodefined cyclopropyl ketones have become readily available and would be an ideal source of linear 3-carbon fragments, but this reactivity is unknown. In this study we show how a new type of C–C activation catalyst, that relies upon a different, metalloradical mechanism, can enable new subsequent reactivity: the cross- coupling of cyclopropyl ketones with organozinc reagents and chlorotrimethylsilane to form 1,3- difunctionalized, ring-opened products. A mixture of experiment and theory sheds light on how cooperation between the redox-active ligand and the nickel catalyst enables the C–C bond activation step, suggesting how this approach could be applied in other systems.
A Strategy for Engineering High Photolysis Efficiency of Photocleavable Protecting Groups Through Cation Stabilization
Authors: Schulte Albert M. , Alachouzos Georgios , Szymanski Wiktor , Feringa Ben L.
Published: April 2022

Photolabile protecting groups (PPGs) enable the precise activation of molecular function with light in many research areas, such as photopharmacology, where remote spatiotemporal control over the release of a molecule is needed. The design and application of PPGs in recent years has particularly focused on the development of molecules with high molar absorptivity at long irradiation wavelengths. However, a crucial and until now mostly neglected parameter, pivotal to the efficiency of uncaging, is the photolysis quantum yield (QY). Here, we describe a novel and general approach to greatly increase the photolysis QY of heterolytic PPGs through stabilization of an intermediate chromophore cation. When applied to coumarin PPGs, our strategy resulted in systems possessing an up to 35-fold increase in QY and a convenient fluorescent readout during their uncaging, all while requiring the same number of synthetic steps for their preparation as the usual coumarin systems. We demonstrate that the same QY-engineering strategy applies to different photolysis payloads and even different classes of PPGs. Furthermore, analysis of the DFT-calculated energy barriers in the first singlet excited state have revealed valuable insights into the important factors that determine photolysis efficiency. The strategy reported herein will enable the development of efficient PPGs tailored for many applications.
Assessing the Breadth of Adduct Formation between Flavouring Molecules and Carrier Fluids within Electronic Cigarette Liquid Products
Authors: Gschwend Grace , Jenkins Caitlin , Kelso Celine , Morgan Jody , Jones Alison
Published: April 2022

Introduction: A range of flavouring molecules are used in electronic cigarette liquids (e-liquids), some of which have been shown to form cyclic acetal adducts with e-liquid solvent components propylene glycol (PG) and vegetable glycerine (VG). The objective of this study was to identify the range of flavouring molecules which form adducts in e-liquid products. Methods: Common e-liquid flavouring molecules (N=36) from a range of chemical class groups were exposed to PG, VG or methanol and analysed by GC-MS over a timeframe of 4 weeks to identify possible reaction products. Results: Adduct formation was observed, with 14 of the flavouring molecules reacting with methanol, 10 reacting with PG and 9 reacting with VG. Where cyclic PG acetals formed, two diastereoisomeric peaks were observed in GC-MS chromatograms, compared to four peaks for VG acetals. All aldehyde-containing flavouring molecules analysed were reactive with PG, VG and methanol. Adducts formed by reaction with ketone-containing flavouring molecules were identified for the first time. Conclusions: A range of adduct products with unknown toxicological safety form in e-liquids through reaction of flavouring molecules and solvent components. PG and VG acetals are likely to form when any aldehyde flavourings are present in e-liquids. PG and VG solvents may also react with ketone-containing flavouring molecules. Implications: This study has established a range of flavouring molecules which are able to react with solvent components PG and VG in e-liquids under standard storage conditions. These newly identified adducts need to be further assessed to determine their toxicological safety.
On the mechanism of theta capillary nanoelectrospray ionization for the formation of highly charged protein ions directly from native solutions
Authors: Brown Susannah , Zenaidee Muhammad , Loo Joseph , Ogorzalek Loo Rachel , Donald William
Published: April 2022

Theta capillary nanoelectrospray ionization (θ-nanoESI) can be used to ‘supercharge’ protein ions directly from solution for detection by mass spectrometry (MS). In native top-down MS, the extent of protein charging is low. Given that ions with more charge fragment more readily, increasing charge can enhance the extent of sequence information obtained by top-down MS. For θ-nanoESI, dual-channelled nanoESI emitters are used to mix two solutions in low to sub-μs prior to MS. The mechanism for θ-nanoESI mixing has been reported to occur in the Taylor cone prior to ESI-droplet formation, or by the fusion of droplets formed from separate Taylor cones. Using θ-nanoESI-ion mobility-MS, native protein solutions were rapidly mixed with denaturing supercharging solutions to form protein ions in significantly higher charge states and with more elongated structures than those formed by pre-mixing the solutions prior to nanoESI-MS. If θ-nanoESI mixing occurred in the Taylor cone, then the extent of protein charging and unfolding should be comparable or less than that obtained by pre-mixing solutions. Thus, these data are consistent with mixing occurring via droplet fusion rather than in the Taylor cone prior to ESI droplet formation. The presence of supercharging additives in pre-mixed solutions can suppress volatile electrolyte evaporation, limiting the extent of protein charging compared to when the additive is delivered via one channel of a θ-nanoESI emitter. In θ-nanoESI, the formation of two Taylor cones can presumably result in substantial electrolyte evaporation from the ESI droplets containing native-like proteins prior to droplet fusion, thereby enhancing ion charging.
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation
Authors: Thomas Morgan , O'Boyle Noel M. , Bender Andreas , de Graaf Chris
Published: April 2022

A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement learning to update a recurrent neural network or language-based de novo molecule generator. However, reinforcement learning can be inefficient, sometimes requiring up to 10^5 molecules to be sampled to optimize more complex objectives, which poses a limitation when using computationally expensive scoring functions like docking or computer-aided synthesis planning models. In this work, we propose a reinforcement learning strategy called Augmented Hill-Climb based on a simple, hypothesis-driven hybrid between REINVENT and Hill-Climb that improves sample-efficiency by addressing the limitations of both currently used strategies. We compare its ability to optimize several docking tasks with REINVENT and benchmark this strategy against other commonly used reinforcement learning strategies including REINFORCE, REINVENT (version 1 & 2), Hill-Climb and best agent reminder. We find that optimization ability is improved ~1.5-fold and sample-efficiency is improved ~45-fold compared to REINVENT while still delivering appealing chemistry as output. Diversity filters were used, and their parameters were tuned to overcome observed failure modes that take advantage of certain diversity filter configurations. Lastly, we find that Augmented Hill-Climb outperforms the other reinforcement learning strategies used on six tasks, especially in the early stages of training or for more difficult objectives. Overall, we hence show that AHC improves sample-efficiency for language-based de novo molecule generation conditioning via reinforcement learning, compared to the current state-of-the-art. This makes more computationally expensive scoring functions, such as docking, more accessible on a relevant timescale.
Spins at work: probing charging and discharging of organic radical batteries by electron paramagnetic resonance spectroscopy
Authors: Kulikov Ilia , Panjwani Naitik A. , Vereshchagin Anatoliy A. , Spallek Domenik , Lukianov Daniil A. , Alekseeva Elena A. , Levin Oleg V. , Behrends Jan
Published: April 2022

Organic radical batteries (ORBs) are a promising class of electrochemical power sources employing organic radicals as redox-active groups. This article reports on the development of a versatile on-substrate electrode setup for spectroelectrochemical Electron Paramagnetic Resonance (EPR) measurements on redox conductive polymers for ORBs. Quantitative in-operando EPR experiments performed on electrochemical cells with a di-TEMPO Ni-Salen polymer as active electrode material demonstrate a strong decrease in the number of paramagnetic centers upon oxidizing the film. The distinct EPR signatures of the TEMPO-containing polymer and its fragments in different molecular environments are used to study its degradation upon repeated cycling. A comparison between the number of EPR-active sites and the number of electrochemically active charges, as measured by cyclic voltammetry, provides information on the nature of the degradation process. Low-temperature ex-situ pulse EPR measurements on the oxidized polymer film reveal the spectrum of dilute nitroxide species, which may be associated with electrochemically inactive islands. These experiments pave the way for advanced EPR techniques for accurately determining distances between adjacent paramagnetic centers and thus for identifying performance-limiting loss mechanisms, which can eventually help develop strategies for making ORBs powerful contenders on the path towards sustainable electrochemical power sources.
Predicting recurrence of uterine myoma after carrying out a selective uterine arteries embolization
Authors: Timchenko Marina A. , Kuznetsova Tatiana A. , Morozova Tatyana I. , Nikolaeva Mariya G.
Published: April 2022

Aim. To establish clinic and anamnestic predictors for recurrence of uterine myomas growth after carrying out a selective uterine arteries embolization (s-UAE).
Materials and methods. The one-center longitudinal retrospective cohort study including 366 women with symptomatic uterine myoma, after carrying out s-UAE at 20132017. The Control group 315 patients after s-UAE with absolute reduction of blood-circulation and strong remission for 3 years. The main group 51 cases of restoration of clinical symptoms and blood-groove after ultrasonography registered absolute reduction and knocking over of clinical symptoms more than two years period. The median of age of control group patients has made 40 years (95% confidence interval 95% CI 39.041.1), the main 42 years (95% CI 39.043.0). In group of comparison it is carried out the analysis of 103 potential risk factors for uterine myomas relapse after s-EMA. For the correlation between uterine myomas relapse and subset quantitative and qualitative signs the model of the logistic regressions was used with a step-by-step elimination of a sign.
Results. Statistically significant risk factors for recurrence of uterine myomas after s-EMA are established: body mass index (BMI) 22,3 (odds ratio OR 4.03); previous plentiful menstrual bleedings (OR 3.56); the previous hormonal therapy (OR 3.06); hypertension (OR 2.58); chronic cystitis (OR 2.18); dyspareunia (OR 2.22); the conglomerate including 23 uterine myomas (OR 1.79); an edge localization of uterine myomas (OR 2.24). Use a logit-models, with inclusion of these specific signs allows to predict uterine myomas growth recurrence after s-EMA in 78.8% cases (95% Cl 0.760.83; р0.0001).
Conclusion. At preoperative consultation stage to patients with symptomatic uterine myoma establishment a combination of criteria "body mass index" (BMI)22.3, previous plentiful menstrual bleedings and previous hormonal therapy, assumes to refuse carrying out s-EMA in advantage alternative method of treatment.
Risk factors for the threat of termination of pregnancy in women with recurrent miscarriage: a suvey-based study
Authors: Malyshkina Anna I. , Grigushkina Elena V. , Talanova Iya E.
Published: April 2022

Background. Habitual miscarriage remains an urgent problem of modern obstetrics and does not tend to decrease.
Aim. To identify risk factors for the threat of abortion in the first trimester in women with recurrent miscarriage.
Materials and methods. A survey of 353 pregnant women at a gestational age of 512 weeks was carried out. The main group consisted of 111 women with signs of the threat of termination at the time of examination and recurrent miscarriage. The control group consisted of 242 women with uncomplicated pregnancy without recurrent miscarriage. Each patient was monitored throughout pregnancy and the postpartum period, the condition of the newborn was assessed according to the medical documentation of the pediatric departments. Statistical data processing was carried out using standard licensed programs Microsoft Excel 2007, the calculation of the odds ratio of risk factors was carried out using the OpenEpi system.
Results. We identified the following risk factors for termination of pregnancy in women with recurrent miscarriage: the age of women over 30; alimentary factors insufficient consumption of meat, eggs, while more frequent use of alcoholic beverages; burdened obstetric and gynecological history: acute/chronic endometritis, endometriosis; the presence of surgical interventions on the pelvic organs in the history of infertility, ectopic pregnancy, anomalies in the development of the genital organs; the presence of extragenital diseases and their combinations, in particular, thyroid disease.
Conclusion. With the timely identification of significant risk factors, it becomes possible to carry out measures aimed at correcting controllable factors, careful pregravid preparation in order to improve the perinatal outcomes of future pregnancy.
Bacterial vaginosis as a risk factor for lower urinary tract infection in women: case report
Authors: Tevlin Konstantin P. , Khanaliev Beniamin V. , Tevlina Ekaterina V.
Published: April 2022

Conservative therapy of acute (exacerbation of chronic) cystitis in women in combination with bacterial vaginosis is a task that often causes difficulties for a practicing doctor. Escherichia coli is still the main causative agent of urinary tract infection due to the presence of virulence factors that not only affect the affinity of the pathogen to the urothelium, but also hinder the development of an immune response. At the same time, bacterial vaginosis is a factor that often accompanies and supports inflammation of the lower urinary tract in women. Simultaneous occurrence of the above conditions is a frequent clinical situation. A differential approach is needed to prescribe antimicrobials to patients with urinary tract infection and bacterial vaginosis, as well as the use of safe natural medicines (biologically active additives) in their complex therapy.
Evaluation of results of combined treatment in patients with disseminated ovarian cancer
Authors: Iurova Mariia V. , Khabas Grigory N. , Pavlovich Stanislav V.
Published: April 2022

Background. According to the modern concept of surgical treatment of ovarian cancer (OC) it is necessary to perform cytoreductive surgery (CRS) without residual tumor in order to achieve more favorable oncological prognoses. However, the possibilities of achieving it with a disseminated process (stages IIIIV) are limited, and therefore, for some patients, neoadjuvant chemotherapy (NACT) is the optimal initial treatment.
Aim. To compare the duration of progression-free survival (PFS) of patients with advanced OC after treatment, as well as to assess the value of the prognostic nutritional index (PNI) in predicting this outcome.
Materials and methods. We conducted a retrospective cohort study of 78 patients with stages IIIIV OC, who received combined treatment between January 2016 and March 2020 (54 patients after primary CRS (PCRS)+platinum-based chemotherapy (CT), 24 patients after NACT+interval CRS (ICRS)+postoperative CT. The predictive value of the PNI was calculated.
Results. The complete PCRS is associated with increased PFS: after complete PCRS 3211.21 months (95% confidence interval CI 10.0953.97); after optimal PCRS 223.46 months (95% CI 15.2128.79); after suboptimal PCRS 147 months (95% CI 0.2827.72). Performing a complete ICRS is associated with decreased PFS compared to PCRS, even if the complete CRS is achieved: after complete ICRS 143.34 months (95% CI 7.4620.54); after optimal ICRS 172.16 months (95% CI 12.7721.23); after suboptimal ICRS 7 months. PNI27.86 correlates with an increased probability of complete PCRS in patients with advanced PCR (AUC 94.3, sensitivity 80%, specificity 91.7%; p0.001).
Conclusion. Achieving complete PCRS in patients with disseminated OC leads to an improvement in the oncological outcome. The prognostic value of pre-treatment calculation of PNI has been revealed: an increased PNI is associated with more favorable perioperative outcomes. Objective criteria should be developed for a strictly reasoned refusal to carry out the first stage of surgical treatment due to the obviously less favorable prognosis of the tactics of "NACT+ICRS+CT".
The Human-Machine Safety Design of Mechanical Toys for Children
Authors: Lv Dan
Published: April 2022

In order to ensure the safety of children while using machineries and avoid harm caused by mechanical toys, this paper analyzes the types and detection standards of children’s toys, discusses the reasons for the harm caused by these toys, and proposes human-machine safety design strategies for children’s toys as reference.
FNAB and Anatomic Pathology Biopsy Accuracy in Thyroid Nodule Diagnosis
Authors: Nugraha Muhammad Tegar , Finansah Yohni Wahyu , Primadina Nova , Yuliyanasari Nurma
Published: April 2022

Background: The problem examined in this study is the accuracy of the FNAB examination compared to the gold standard histopathology.Objective: To determine the value of sensitivity, specificity, positive and negative predictive values , and the accuracy of the FNABMethod: This study uses a retrospective method. The population was patients with thyroid nodules in Pare Regional Hospital, Kediri, in 2015-2019. The sampling technique is Simple Random Sampling Probability. The sample was the patients who had been diagnosed with thyroid nodules and underwent FNAB examination followed by histopathology biopsy. The instrument used was secondary data collection inpatient medical record data. The data can be processed through diagnostic tests.Results: FNAB sensitivity value of 66.6%, a specificity value of 97%, a positive predictive value of 90.9%, and a negative predictive value of 86.8%, and an accuracy rate of 87.7%Conclusion: FNAB can be used as a first-line examination in diagnosing thyroid nodules but cannot replace histopathological examination as a gold standard.
Autism Spectrum Disorder (ASD) Therapy in the Era of the Covid-19 Pandemic
Authors: Faadhilah Aisyah , Prasetya Era Catur , Dinata M. Thoriq Satria , Rohmah Lina Nur Hidayahtur , Nerly Wichda Shirosa , Prastya Aldo Dwi , Abiola Tajudeen
Published: April 2022

Background: Autism Spectrum Disorder is a common neurodevelopmental disorder with a reported prevalence in the United States of around 1.7%. The core deficits of ASD were identified in 2 domains: social communication/interaction and restrictive, repetitive behavior patterns. Children and adolescents with ASD have service needs in behavior, education, health, recreation, family support, and other areas. For individuals with autism spectrum disorders, school and therapy services can serve various essential functions, from delivering academic instruction to developing effective communication and building social skills.Objective: This study is to examine ASD during the COVID-19 pandemic. The researcher has emphasized the importance of specific therapies for children with ASD and has repeatedly shown their association with positive outcomes across various skill domains.Method: The literature review is processed based on academic journals published on Science Direct, PubMed, and Google Scholar, from 2019 to 2020.Results: The study found various methods and learning methods for children with ASD in the COVID-19 pandemic.Conclusion: Many obstacles have been overcome for children with ASD and therapists during the COVID-19 period. Suggestions and tips for parents and therapists to take further action on children.
Religious Aspects of Depression in the Elderly
Authors: Rahmadayani Annisa , Boy Elman , Achsanudin Muhammad Rijal
Published: April 2022

Background: Elderly population (Elderly) is people who are aged 60 years and over. The increase in life expectancy leads to an increase in the number of elderly populations. This increase leads to an increased risk of physical and mental illness. The prevalence of the population suffering from depression in the elderly is 5 percent to 10 percent. Religious behavior seems to minimize stress levels, misbehavior, provide social support and help individuals find meaning in life.Objective: To find out the religious aspect of depression in the elderlyMethod: Type of study is a literature review. The literature search, both international and national, adapted to PICOT and journal search terms through MESH (Medical Subject Heading), restrictions on taking journals, and other things. Journal used in a literature review. This was obtained through the Scientific Indonesia journal provider database through Google Scholar. In this study, researchers used keywords according to MESH, namely "religiosity," "depression," "elderly," and selected full text.Result: Elderly is more than 60 years old. This is in accordance with the Minister of Social Affairs Regulation of Indonesia Number 05 of 2018 concerning Elderly Welfare. The high life expectancy in the elderly certainly increases the risk of mental and physical illness in the elderly. The quality of life in the elderly begins to decrease, which makes the elderly susceptible to depression.Conclusion: Depression in the elderly can be decreased by increasing the aspect of religiosity in the elderly.
The Effectiveness of Lactobacillus plantarum Administration in Patients with Atopic Dermatitis
Authors: Izzati Ismatu Aghni Fatwa , Pramuningtyas Ratih , Bestari Rochmadina Suci , Nurhayani Nurhayani
Published: April 2022

Background: Atopic dermatitis is a chronic and residual inflammatory skin disease with increased prevalence in every year. The medications that are often given can cause serious side effects if it given in the long-term. The treatment of Lactobacillus plantarum is expected to be safer long-term treatment option for patient with atopic dermatitis.Objective: The objective is to determine the effectiveness treatment of Lactobacillus plantarum in patients with atopic dermatitis.Method: The research design was a Systematic Review with a qualitative approach using meta-synthesis analysis type. The search was conducted on 3 databases: PubMed, Science Direct, and Google Scholar. Result: Total articles obtained were 239 with 16 duplicate data. 211 articles were included in the exclusion criteria and 5 articles were interventions with combination probiotics. So there are 7 articles included in the research with clinical trials, open trials, pilot studies, and 4 research using the randomized controlled trial Double Blind design. All results showed improvement in symptoms with the SCORAD index or Skindex-16. Several studies also measured IgE, IL-4, IL-10, IL-13, IL-17, the percentage of Th1, Th2, Treg, TGF-β, IFN-γ and obtained different  results. Conclusion: Treatment of Lactobacillus plantarum in patients with atopic dermatitis is effective to reducing symptoms and as an immunomodulator.
Co-Existence of Tuberculosis and Lung Cancer
Authors: Aribowo Kornelis , Medison Irvan , Mizarti Dessy , Fitrina Dewi Wahyu
Published: April 2022

Background: Tuberculosis (TB) and lung cancer cause significant morbidity and mortality worldwide and pose a global health threat. Each year these two diseases account for more than 1.6 million deaths worldwide. The incidence of both diseases is still high in many developing countries, especially in Asian countries. TB and lung cancer are often confused and misdiagnosed, especially in countries with diagnostic challenges of low TB incidence and risk of missed diagnosis.Case Presentation: The following is a case report of a 53-year-old male patient diagnosed with pulmonary TB accompanied by right lung cancer, and the same respiratory complaints can be had by lung cancer and TB. However, the presence of facial edema (part of the superior vena cava syndrome) causes clinicians to focus more on lung cancer so that the diagnosis of TB is often overlooked.Conclusion: Tuberculosis should be a significant concern, especially in patients with malignancies such as lung cancer and located in TB endemic areas. Delay in diagnosis and or miss diagnosis will affect the patient's outcome.
Pengaruh Pemahaman Wajib Pajak, Sanksi Denda Pajak dan Kesadaran Wajib Pajak Terhadap Kepatuhan Wajib Pajak UMKM di KPP Pratama Rungkut Surabaya
Authors: Pratiwi Fikih Fadillyna , Susanti Susanti
Published: April 2022

The purpose of this study is to determine the influence of understanding, fines and awareness of taxpayers on MSME taxpayer compliance. This type of research is quantitative research. The population in this study is MSMEs registered at KPP Pratama Rungkut Surabaya with the number of sample of 40 active taxpayers. method data collection using questionnaires and tests. Technique Analysis of the data used Multiple Linear Regression using IBM SPSS statistic 25 for windows program. The results show that the understanding, fines and awareness of taxpayers had a significant effect on MSME taxpayer compliance either simultaneously or partially.
Pengembangan Permainan Accounting Maze Berbasis Android Sebagai Media Pengayaan
Authors: Budiono Erika Agustina , Rochmawati Rochmawati
Published: April 2022

The purpose of this development research is to produce an android-based accounting maze game as an enrichment media for notes receivable which can be used as a reference for teachers as an enrichment media in order to motivate students during an enrichment process. The development model was adapted from the ADDIE development model recommended by Reiser and Mollenda through the Analysis, Design, Development, Implementation steps, but leaving the last step namely Evaluation. The results of the feasibility test from material experts and media expert in this research indicate that the android-based accounting maze game as an enrichment media obtained a very decent interpretation. In addition, the acquisition of the student response questionnaire received with a very understanding interpretation, therefore from the results of these percentages it can be concluded that the android based accounting maze game as a media of enrichment in notes receivable it stated to be very suitable for use in enrichment activities inside or outside the classroom.
Analisis Faktor-Faktor Yang Memengaruhi Perilaku Konsumtif Siswa Program Keahlian Akuntansi SMKN 1 Surabaya
Authors: Wahyudi Reysa Anggita , Rochmawati Rochmawati
Published: April 2022

Consumptive is an activity of purchasing and using products or services in excess to obtain maximum satisfaction. This study intends to conduct testing and analysis of the factors of consumer behavior in the form of lifestyle, peer groups, self-control, and financial literacy. The research conducted is an associative type and uses quantitative methods. The population studied was all students of class X - XI Accounting skills program SMK Negeri 1 Surabaya, with a total sample of 90 students. The sampling technique is simple random sampling and the data collection is done using a questionnaire and tests. Data analysis was performed through the classical assumption test, multiple linear regression test, and hypothesis testing. The results obtained are: (1) Partial influence of lifestyle, peer groups, self-control, and financial literacy on consumer behavior is found; (2) The partial influence of lifestyle on the consumptive behavior of students positively and significantly; (3) The partial influence of peer groups on consumptive behavior positively and significantly; (4) The influence of self-control on students' consumptive behavior negatively and significantly; (5) There is no partial effect of financial literacy on consumer behavior.
Investasi Pendidikan Melalui Keikutsertaan Bimbingan Belajar Online: Mampukah Mempengaruhi Hasil Belajar Siswa?
Authors: Haliza Destin Siti Nur , Sholikhah Ni'matush
Published: April 2022

One form of household expenditure is in the form of education investment. Investment in education has a good impact on the future of children. Participation in online tutoring is one way for parents to support their child's education. This study aims to determine the effect of student participation in online tutoring on learning outcomes of economics subjects in class XI IPS SMAN 14 Surabaya. This study uses regression analysis techniques with dummy variables. This study resulted in a significant and positive effect of student participation in online tutoring on learning outcomes. The acquisition of student learning outcomes is greater when students participate in online tutoring compared to students who do not take online tutoring.