bluuebunny/crossref_metadata_2025 huggingface dataset:
Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration inC. elegansModels of Parkinson's Disease
Authors: Martinez Bryan A. , Petersen Daniel A. , Gaeta Anthony L. , Stanley Samuel P. , Caldwell Guy A. , Caldwell Kim A.
Published: October 2017

Due to environmental insult or innate genetic deficiency, protein folding environments of the mitochondrial matrix are prone to dysregulation, prompting the activation of a specific organellar stress-response mechanism, the mitochondrial unfolded protein response (UPRMT). InCaenorhabditis elegans, mitochondrial damage leads to nuclear translocation of the ATFS-1 transcription factor to activate the UPRMT. After short-term acute stress has been mitigated, the UPRMTis eventually suppressed to restore homeostasis toC. eleganshermaphrodites. In contrast, and reflective of the more chronic nature of progressive neurodegenerative disorders such as Parkinson's disease (PD), here, we report the consequences of prolonged, cell-autonomous activation of the UPRMTinC. elegansdopaminergic neurons. We reveal that neuronal function and integrity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell death. In a PD-like context wherein transgenic nematodes express the Lewy body constituent protein α-synuclein (αS), we not only find that this protein and its PD-associated disease variants have the capacity to induce the UPRMT, but also that coexpression of αS and ATFS-1-associated dysregulation of the UPRMTsynergistically potentiate dopaminergic neurotoxicity. This genetic interaction is in parallel to mitophagic pathways dependent on theC. elegans PINK1homolog, which is necessary for cellular resistance to chronic malfunction of the UPRMT. Given the increasingly recognized role of mitochondrial quality control in neurodegenerative diseases, these studies illustrate, for the first time, an insidious aspect of mitochondrial signaling in which the UPRMTpathway, under disease-associated, context-specific dysregulation, exacerbates disruption of dopaminergic neuronsin vivo, resulting in the neurodegeneration characteristic of PD.

SIGNIFICANCE STATEMENTDisruptions or alterations in the activation of pathways that regulate mitochondrial quality control have been linked to neurodegenerative diseases due in part to the central role of mitochondria in metabolism, ROS regulation, and proteostasis. The extent to which these pathways, including the mitochondrial unfolded protein response (UPRMT) and mitophagy, are active may predict severity and progression of these disorders, as well as sensitivity to compounding stressors. Furthermore, therapeutic strategies that aim to induce these pathways may benefit from increased study into cellular responses that arise from long-term or ectopic stimulation, especially in neuronal compartments. By demonstrating the detrimental consequences of prolonged cellular activation of the UPRMT, we provide evidence that this pathway is not a universally beneficial mechanism because dysregulation has neurotoxic consequences.
Early sex-dependent differences in response to environmental stress
Authors: Pérez-Cerezales Serafin , Ramos-Ibeas Priscila , Rizos Dimitrios , Lonergan Pat , Bermejo-Alvarez Pablo , Gutierrez-Adan Alfonso
Published: October 2017

Greek:

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Special:

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Math:

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Latin:

ÀŸšŠœŒěĚčČċćĆăĂāÿýüûúùøöõôóòñïîíìëêéèçæåäãâáàÝÜÛÚÙØÖÕÔÓÒÑÏÎÍÌËÊÉÈÇÆÅÄÃÂÁ

Developmental plasticity enables the appearance of long-term effects in offspring caused by exposure to environmental stressors during embryonic and foetal life. These long-term effects can be traced to pre- and post-implantation development, and in both cases

the effects are usually sex-specific. During preimplantation development, male and female embryos exhibit an extensive transcriptional dimorphism mainly driven by incomplete X-chromosome inactivation. These early developmental stages are crucial for the

establishment of epigenetic marks that will be conserved throughout development, making it a particularly susceptible period for the appearance of long-term epigenetic-based phenotypes. Later in development, gonadal formation generates hormonal differences

between the sexes, and male and female placentae exhibit different responses to environmental stressors. The maternal environment, including hormones and environmental insults during pregnancy, contributes to sex-specific placental development that controls genetic

and epigenetic programming during foetal development, regulating sex-specific differences, including sex-specific epigenetic responses to environmental hazards, leading to long-term effects. This review summarizes several human and animal studies examining sex-

specific responses to environmental stressors during both the periconception period (caused by differences in sex chromosome dosage) and placental development (caused by both sex chromosomes and hormones). The identification of relevant sex-dependent trajectories caused by sex-chromosomes and/or sex-hormones is essential to define diagnostic markers and prevention/intervention protocols.
APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication inCaenorhabditis elegans
Authors: Medley Jeffrey C , DeMeyer Lauren E , Kabara Megan M , Song Mi Hye
Published: October 2017

As the primary microtubule-organizing center, centrosomes play a key role in establishing mitotic bipolar spindles that secure correct transmission of genomic content. For the fidelity of cell division, centrosome number must be strictly controlled by duplicating only once per cell cycle. Proper levels of centrosome proteins are shown to be critical for normal centrosome number and function. Overexpressing core centrosome factors leads to extra centrosomes, while depleting these factors results in centrosome duplication failure. In this regard, protein turnover by the ubiquitin-proteasome system provides a vital mechanism for the regulation of centrosome protein levels. Here, we report that FZR-1, the Caenorhabditis elegans homolog of Cdh1/Hct1/Fzr, a coactivator of the anaphase promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase, functions as a negative regulator of centrosome duplication in the C. elegans embryo. During mitotic cell division in the early embryo, FZR-1 is associated with centrosomes and enriched at nuclei. Loss of fzr-1 function restores centrosome duplication and embryonic viability to the hypomorphic zyg-1(it25) mutant, in part, through elevated levels of SAS-5 at centrosomes. Our data suggest that the APC/CFZR-1 regulates SAS-5 levels by directly recognizing the conserved KEN-box motif, contributing to proper centrosome duplication. Together, our work shows that FZR-1 plays a conserved role in regulating centrosome duplication in C. elegans.
Colorectal cancer in the world: incidence, mortality and risk factors
Authors: Gandomani Hamidreza Sadeghi , Yousefi Seyed Majid , Aghajani Mohammad , Mohammadian-Hafshejani Abdollah , Tarazoj Abed Asgari , Pouyesh Vahideh , Salehiniya Hamid
Published: October 2017

A rapid literature search strategy was conducted for all English language literature published before July 2017. The search was conducted using the electronic databases PubMed, Scopus and Web of Science. The search strategy included the keywords ‘colorectal cancer’, ‘epidemiology’, ‘incidence’, ‘mortality’, ‘risk factor’, and ‘world’. In 2012, the highest CRC incidence rates were observed in the Republic of Korea, Slovakia and Hungary while the lowest incidence rates were seen in Singapore, Serbia and Japan. The highest CRC mortality rates in both sexes were seen in Central and Eastern Europe and the lowest mortality rates were found in Middle Division of Africa. The main risk factors for CRC include nutritional factors, past medical history, smoking, socioeconomic status, and family medical history. According to the increasing trend of CRC incidence and mortality in the world, implementation of prevention programs such as screening programs, diet modification, and healthy lifestyle education is necessary.

Peer Review Details

Peer review method: Single-Blind (Peer-reviewers: 02) Peer-review policy

Plagiarism software screening?: Yes

Date of Original Submission: 26 August 2017

Date accepted: 20 Sept 2017

Peer reviewers approved by: Dr. Lili Hami

Editor who approved publication: Dr. Phuc Van Pham
Technology and Teaching Culture: Results of a State Survey of Foreign Language Teachers
Authors: Moore Zena , Morales Betsy , Carel Sheila
Published: October 2017

Findings from a state survey on technology and teaching culture indicated that teachers in general made little use of computer facilities such as the World Wide Web and e-mail. Although the teachers made considerable use of video materials, especially foreign films, they made little use of interactive media such as CD-ROMs and videodiscs even when these materials were part of commercially available instructional packages. Teachers' level of education and teaching experience accounted for some of the differences in the frequency with which teachers used technology. The study also found that Japanese teachers demonstrated more frequent use of technology than teachers of other foreign languages. Teachers in rural areas appeared to make very little use of interactive media learning materials. It is clear that foreign language teachers need to improve their knowledge of how to integrate technology with other activities in classroom instruction. This need could be met by including instructional technology issues in courses for pre-service and in-service teachers.
Extending the Dialogue: Using Electronic Mail and the Internet to Promote Conversation and Writing in Intermediate Level German Language Courses
Authors: Van Handle Donna C. , Corl Kathryn A.
Published: October 2017

This article presents and analyzes the results of a cooperative E-mail project conducted at Mount Holyoke College and The Ohio State University. The project was designed to determine whether an E-mail exchange between two intermediate level German classes at both institutions would help improve students' speaking and writing in German. Suggestions and practical tips are also offered to instructors who wish to conduct a similar Email exchange with their students.
From CD-ROM to the WWW: Coming Full Circle
Authors: Burston Jack
Published: October 2017

This article describes the challenges faced and solutions adopted in adapting a multimedia-rich CD-ROM program, the Variétés de français program, to operation over the World Wide Web (WWW). While full web functionality offered the promise of flexible network distribution, it also had to confront the dual limitations of multimedia authoring systems and web based programming. In seeking to combine the best of full multimedia programming and centralized WWW mediated delivery, the Variétés de français-WWW program has come full circle to the CD-ROM for its base. The program runs locally to retrieve media resources, perform intelligent answer processing, and data collection and turns to the web only when necessary for data transfer, external WWW links, and electronic communication. Given the current state of the art, the article concludes that such a hybrid solution offers the most effective approach to courseware development.
Networked Multimedia and Foreign Language Education
Authors: Yang Peter J.
Published: October 2017

Both multimedia applications and computer networks are well known, excellent tools for foreign language learning. However, networked multimedia--the ideal combination of both tools--is relatively new and potentially troublesome to many language professionals. Some institutions have started to experiment with a combination of multimedia and networks, and it is helpful to explore uses, problems, and solutions of networked multimedia for foreign language learning. This article presents information on the importance (and difficulties) of setting up networked multimedia environments for language education and discusses some possible solutions for the strategic transition to this new instructional format.
The Effects of Keyword Captions to Authentic French Video on Learner Comprehension
Authors: Gant Guillory Helen
Published: October 2017

The common practice in captioning video programs for foreign language instruction is to transcribe the spoken language verbatim into captions. This practice presents a dense visual channel for foreign language learners. The study presented here tested a keyword captioning method based on the hypothesis that keyword captions present learners with less to read without attenuating their comprehension of the information in the spoken message. The design of the experiment was simple; the use of three different amounts of text on video were compared: full text, keywords, and no text. The results of the experiment showed that the keyword captions group outperformed the no-text group and that the full text captions group outperformed the keyword captions group; however, a post-hoc analysis revealed no significant difference between the means of the full text captions group and the keyword captions group. The positive effect of both keyword and full text captions on comprehension, the basic research hypothesis, is confirmed.
Elements of Research in CALL Software Development Projects
Authors: Dodigovic Marina
Published: October 2017

CALL is a relatively young discipline and is greatly affected by the consequences of a predominant focus on program development at the expense of basic research. The central issue of this paper involves the integration of research components into the CALL development process for the purpose of not only improving the quality of software but also demonstrating how empirical observations that emerge during the course of development can have an important impact on underlying theory.
Growth of Internet Use by Language Professionals
Authors: Fidelman Carolyn G.
Published: October 2017

This article presents a report on the use of the Internet by language professionals, particularly foreign language teachers. The report shows a dramatic increase in the use of the Internet beginning in 1993. Listserves, EMail, Discussion Groups, and especially the World Wide Web are predominate among the services included in the Internet. Common Web activities include teaching teachers how to use the Web, locating information at Web sites for use in classes, putting reading passages and other materials at Web sites for student use, and having students search for information on the Internet. Continued moderate growth in Web usage can be expected. However, if K-12 foreign language teachers receive appropriate equipment and training, the profession could well witness another dramatic upsurge in use of the Internet.
Use of Speech Recognition Software as an English Language Oral Assessment Instrument
Authors: Coniam David
Published: October 2017

This paper explores the potential for the use of speech recognition technology to test the oral proficiency of learners of English as a second language. The study described here follows from an earlier study in which subjects read a text aloud into the speech recognition software Dragon NaturallySpeaking and extends that study to include the analysis and scoring of the output of the speech recognition software by means of a computer program. Results indicate that the computer program discriminated well between the native and non-native speakers and also correlated highly with the results of traditional analyses. The paper concludes with the note of circumspection by pointing out that the current implementation of speech recognition technology is still far from being readily usable primarily because the technology is speaker-dependent and has to be trained to recognize each person's voice.
Processing murine tissues into sections v1
Authors: Hemmeryckx Bianca , Bauters Dries , Roger Lijnen H.
Published: October 2017

Processing murine tissues into paraffin sections.
Molecular expression analysis using DNA microarray and KeyMolnet®? v1
Authors: Fujishima Hajime , Fumoto Shoichi , Etoh Tsuyoshi , Inomata Masafumi
Published: October 2017

Background Recently, neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (NAC-DCF) was identified as a novel strong regimen with a high rate of pathological complete response (pCR) in advanced esophageal cancer in Japan. Predicting pCR will contribute to the therapeutic strategy and the prevention of surgical invasion. However, a predictor of pCR after NAC-DCF has not yet been developed. The aim of this study was to identify a novel predictor of pCR in locally advanced esophageal cancer treated with NAC-DCF. Patients and Methods A total of 32 patients who received NAC-DCF followed by esophagectomy between June 2013 and March 2016 were enrolled in this study. We divided the patients into the following 2 groups: pCR group (9 cases) and non-pCR group (23 cases), and compared gene expressions between these groups using DNA microarray data and KeyMolnet. Subsequently, a validation study of candidate molecular expression was performed in 7 additional cases. Results Seventeen molecules, including transcription factor E2F, T-cell-specific transcription factor, Src (known as “proto-oncogene tyrosine-protein kinase of sarcoma”), interferon regulatory factor 1, thymidylate synthase, cyclin B, cyclin-dependent kinase (CDK) 4, CDK, caspase-1, vitamin D receptor, histone deacetylase, MAPK/ERK kinase, bcl-2-associated X protein, runt-related transcription factor 1, PR domain zinc finger protein 1, platelet-derived growth factor receptor, and interleukin 1, were identified as candidate molecules. The molecules were mainly associated with pathways, such as transcriptional regulation by SMAD, RB/E2F, and STAT. The validation study indicated that 12 of the 17 molecules (71%) matched the trends of molecular expression. Conclusions A 17-molecule set that predicts pCR after NAC-DCF for locally advanced esophageal cancer was identified.
Manajemen Risiko Infrastruktur Cloud Pemerintah Menggunakan Nist Framework Studi Kasus Lembaga Ilmu Pengetahuan Indonesia (LIPI)
Authors: Prabowo Wahyu Setyo , . Widyawan , A Setiawan Noor , Muslim M. Hanif , Utama Yoga S
Published: October 2017

Lembaga Ilmu Pengetahuan Indonesia (LIPI) sejak tahun 2015 telah menggunakan teknologi cloud computing sebagai pengganti infrastruktur data center yang mengalami kerusakan. Teknologi ini merupakan hal baru bagi LIPI. Setiap penerapan teknologi baru, organisasi dihadapkan berbagai peluang dan risiko yang dapat mempengaruhi kinerja organisasi tersebut baik positif maupun negatif. Terlebih cloud computing merupakan salah satu skema outsourcing TIK sehingga manajemen risiko yang tepat harus dilaksanakan. Tujuan penelitian ini adalah melakukan manajemen risiko terhadap penggunaan teknologi cloud computing menggunakan framework yang tepat sehingga manfaat dari teknologi tersebut dapat diperoleh secara maksimal. Penelitian ini menggunakan framework NIST SP800-37 revision 1 Guide for Applying the Risk Management Framework to Federal Information Systems. Pemilihan framework ini karena sudah banyak diterima berbagai institusi baik pemerintah maupun profesional. Selain itu framework ini telah diadaptasi untuk bisa menyesuaikan dengan lingkungan cloud. Enam tahapan dalam framework ini hanya dapat dilaksanakan sampai tahapan ketiga karena keterbatasan penelitian. Hasil dari penelitian yang telah terlaksana sampai tahap ketiga adalah tersusunnya dokumen rencana keamanan yang merupakan bagian dari proses manajemen risiko. Diharapkan dokumen rencana keamanan yang berisi kategorisasi sistem informasi, tipe informasi, dan kontrol keamanan yang terpilih dapat diimplementasikan sehingga keamanan lingkunga cloud dapat terjamin.
Penerapan Algoritma Tripod Gait pada Robot Hexapod Menggunakan Arduino Mega128
Authors: Chairunnas Andi
Published: October 2017

The movement of the robot with wheels almost do not experience problems setting when road conditions tend to be flat or bypassed. However, problems arise when the condition of the streets where tend to be broken or wavy. With these problems legged robot is suitable for solving the problem. Legged robot itself is divided on several types, among others, two-legged robot (humanoid), four-legged robot (Quadpod), and a six-legged robot (Hexapod). This research will be discussed on how to build a Hexapod robot control at the system by applying the pattern step tripod gait on a Hexapod robot so that the accuracy of movement applied on a Hexapod Robot will produce the maximal movement patterns. In addition before determining the pattern step shall be applied forward gait tripod kinematic. Generally forward kinematic derived from around the corner join configuration so that the position of the end effector in Cartesian spaces (x, y) can determine the position of the corners on a servo motor from different corners of the position or angle of the servo value used to form the shape of the foot of each leg can determine the changes when the maneuver. It was only the application of pattern step tripod gait can be done, the robot can run well and constant can even generate some movement such as forward, backward, turn left, turn right. On testing the movement Forward in open areas and advanced on the Area Covered with an average speed of 5 cm/s, testing Motion backward on open areas and retreat in enclosed areas with an average speed of 4.32 cm/s, testing the rotary motion Right on open and Turning Right on Closed with an average speed of 13 degrees/minutes, testing the rotary motion of the left in the open and Turning left on Closed with an average speed of 12.85 degrees/sec The power needed, overall testing on areas of open and enclosed areas is 0.3 Volts with an overall duration of use 240.8 seconds.
Perancangan Aplikasi Sistem Presensi Siswa Berbasis Andriod pada SMP Negeri 2 Tinambung
Authors: Aprizal Aphry
Published: October 2017

Behavior skipped school on teenagers today can be grouped into several factors such as personal or students themselves are associated with loss of academic interest of students, the conditions to miss class, or because of juvenile delinquency, while also family factors that play a role in the effect of these include lack of participation parents / guardians in the education of the child, absences manual currently implemented using the mail so it took a prescribed period of school in order to know the status of their children, therefore the purpose of the application of the system presence of students based on android is the observation of the parents / guardians on their children periodic dependent classes, based on the problems faced by the school aimed to design a mobile application and website. The method used is the design of data collection directly to the activities and get the data from the school authorities using a data storage device. This application using GPRS / HSDPA or WiFi as connectivity, the media, this application can be used by teachers and parents / guardians of the students and is able to provide information on the presence status of students for parents / guardians of students online.
Pengembangan Aplikasi Repositori Karya Ilmiah LIPI Berbasis Mobile (Development of Scientific Paper LIPI Repository Mobile Application)
Authors: Prasetyadi Abdur Rakhman , Nurhadryani Yani
Published: October 2017

Abstrak

Repositori LIPI berfungsi untuk menghimpun output intelektual peneliti salah satunya adalah karya ilmiah yang diterbitkan oleh institusinya. Adapun permasalahan pada penelitian ini adalah bagaimana pengguna dapat mengakses karya ilmiah yang lebih efisien dan bagaimana kontributor dapat mengunggah karya ilmiahnya secara mandiri. Tujuan dari penelitian ini adalah mengembangkan aplikasi Repositori karya ilmiah LIPI berbasis mobile untuk membantu pengguna lebih mudah mengakses karya ilmiah yang telah diunggah oleh kontributor di LIPI. Metode dan teknologi yang digunakan adalah aspek-aspek user experience (UX) dan perangkat lunak APP Inventor. Hasil dari penelitian ini telah berhasil membuat tampilan antarmuka aplikasi maka pengguna dapat dengan mudah mencari, menelusur dan membaca karya ilmiah. Selain itu, juga memudahkan para kontributor untuk mengelola konten seperti mengunggah/edit/hapus karya ilmiah melalui laman kontributor. Hasil pengujian akhir aplikasi menunjukkan bahwa dari segi tampilan dan fitur sudah cukup baik, error (rate) hanya 11,1%.

Abstract

 

LIPI repository was built to muster scientific works produced by scientists, including papers published by their own institutions. While the problem of this research was how users could find and access papers efficiently and how contributors could upload their works by themselves. The goal of the research was to develop a prototype application. Mobile based LIPI scientific repository focused on three aspects, which are users need analysis, prototype application development and prototype application trial. Method and technology used in the research was using user experience (UX) aspects and APP Inventor software. The result of the research was successfully developed an interface application view so it will be easier for users to search, browse and find papers. On the other hand, it would be easier for contributors to manage the content, such as uploading/editing/erasing papers using contributors’ page. The final trial result showed that the application’s view and feature was good, with error (rate) of only 11.1%.
Study of impact of anemia on pregnancy
Authors: Maka Shradha S. , Tondare Sangamesh B. , Tondare Mahesh B.
Published: October 2017

Background: Anemia during pregnancy is highly prevalent in developing countries like India. Mostly is nutritional, of which iron deficiency anemia is predominant. Pregnancy is a state of hemodilution, also there is increased requirement of iron and folic acid during pregnancy. The incidence varies with socioeconomic status, literacy. Anemia has adverse outcome on both mother and fetal health. Poor fetal outcome like increase in preterm deliveries, increase in intrauterine growth restriction, increase in NICU admission, intrauterine death is seen. Maternal complications increase with anemia. This study aims to study the prevalence, type of anemia and its effect on mother and fetus. Objective of present study were to investigate the type and degree of anemia and to study the maternal and perinatal outcome.Methods: This study was done in department of obstetrics and gynecology in M. R. Medical college kalaburagi for 1 year. Study was conducted on 100 pregnant women. Haemoglobin estimation was done for all woman in 3rd trimester. Severity of anemia was detected by ICMR (Indian Council of Medical Research) classification. Depending on degree and type of anemia all were treated and followed up for maternal and perinatal outcome.Results: The incidence of mild, moderate, severe anemia were 28%, 54%, 18% respectively. Most of the anemic woman belonged to low socioeceonomic status 84%. 16% had maternal complications. Poor perinatal outcome was seen in unbooked and referred cases.Conclusions: Anemia continues to be a major problem in developing countries with poor maternal and neonatal outcome. Early diagnosis and treatment can improve both maternal and neonatal outcome.
Correlation of the HPV genotype with the degree of dysplasia in patients with cervicouter cancer in the General Hospital Naval of high specialty
Authors: Morales Oyuki A. , Araiza Junior J. , Garay María Del R. , Barbabósa Jorge A. , Gutiérrez Marlene De la P.
Published: October 2017

Background: Cervical-uterine cancer (CaCu) is the second leading cause of death in women worldwide and the first in developing countries. It has been correlated to human papillomavirus (HPV) genotype with cancerous lesions reported in histopathological studies, which tells us about the prognosis of the patients. Objective of present study was to correlate the genotype of HPV to the histopathological result evaluated in these patients at the Naval Hospital of High Specialty.Methods: A total of 316 women attended at the Naval General High Marine Hospital from 2015 to 2016 with HPV diagnosis were included, the histopathological report was correlated with the HPV genotype determined by the chain reaction of the polymerase (PCR). Statistical tests were applied for Smirnov and Kolmogorov, Chi square, OR, Anova-Kruskal Wallis. Data were processed using the SPSS software version 19 and a P <0.05 was taken as statistical significance.Results: The mean age was 36.0±10.2. The detection of cervical cancer was reported in 3.8% and stage CIN III 2.5%; the highest proportion of patients were in the CIN I stage (51.3%), while the CIN II was 9.2%, and up to 30.7% were classified as HPV infection; only 2.5% were normal. The types of HPV prevalent by PCR were those at high risk different from 16 and 18 with a rate of 34.8%, then 16 at 5.1% and 18 at 0.3%. More than half of the cases (54.4%) were negative for the serotypes analyzed. In general terms, CaCu and CIN III were observed in 15% of the type 16, 0% in type 18, 25% in other high risk and 60% in negative PCR.Conclusions: In this study, we obtained essential data that tells us that this population could be treated with low-risk HPV types associated with CaCu.
Doppler velocimetry of umbilical, and middle cerebral arteries in the prediction of fetal outcome
Authors: P. K. Sumangali , E. K. Omana , S. Nambiar Shabnam
Published: October 2017

Background: Doppler ultrasound offers a unique non-invasive technology for investigating fetal, feto placental and utero placental circulation Intrauterine growth restriction is associated with increased perinatal morbidity and mortality.Methods: A hospital based descriptive study of Doppler velocimetry of umbilical Artery and Middle cerebral Artery was carried out in the Department of Obstetrics and Gynecology Pariyaram Medical College over a period of 1 year – April 2016 to March 2017. A total of 180 patients with clinically IUGR were selected for the study. Close monitoring done with daily NST and repeated Doppler study.Results: The S/D ratio in Umbilical artery and RI ratio of MCA is valuable for monitoring growth retarded and small for gestational age fetuses and to take decision for early termination of pregnancy. In our study, perinatal outcome is very good, only 3 NND happened. i.e., due to extreme prematurity.Conclusions: Colour Doppler helps in detection of compromised fetuses in high risk pregnancies like PIH, IUGR and other risk factors likely to cause placental insufficiency.
Cerebral salt wasting in a case of tubercular meningitis in a child
Authors: Bainade Kapil , Kotrashetti V. , Sonwane Vijay , Ahmed Rizwan , Abusaria Prashant
Published: October 2017

A 12-year-old female child presented with fever, headache, vomiting since 20 days and convulsions for 1 day. She was unimmunised and BCG scar was absent. Clinical examination showed signs of meningeal irritation, Kernigs sign and Brudzinkins sign with signs of raised intracranial tension. Fundus examination was suggestive of stage 2 papilledema. Her laboratory reports were normal on admission. LP was with hold in view of raised ICT. CT brain was done. S/O meningeal enhancement, mild communicating hydrocephalus with periventricular ooze, extra axial hyper densities in bilateral sylvian fissures along the tentorium (Basal Exudates) On day 3 of admission she had low serum sodium, serum osmolality High urinary sodium. While on lumbar puncture (LP) and cerebrospinal fluid (CSF) examination, CSF protein, and total leukocyte count (predominant lymphocytes) were all increased. On his 5th day of admission, her serum sodium was low and he had a normal urine output. Fluid restriction was tried in order to rule out syndrome of inappropriate antidiuretic hormone secretion (SIADH) but the patient did not respond to it. Keeping in view the above findings, a final diagnosis of tuberculous meningitis leading to cerebral salt wasting syndrome was made. The patient was started on anti-tuberculous therapy (ATT), IV Steroids, anticonvulsants, 3% NaCl and supportive treatment, to which she responded favourably and was later discharged.
Operative management of tibial plateau fractures: an assessment of functional and radiological outcomes with Rasmusssens scoring system
Authors: Subash Yeshwanth , Dhamu Ilavarasan M. , B. Jagadeesh , N. Preethi , Jayaram Manoj , Naidu Gunalan K.
Published: October 2017

Background: Fractures of the proximal tibia involve a major weight bearing joint and are intra-articular injuries which frequently result in functional impairment. They require an accurate reduction of the articular surface with stable internal fixation. If these fractures are not managed appropriately, they often result in high rates of morbidity in the form of knee stiffness and arthritis. This study was done to assess the functional and radiological outcomes following various surgical modalities and to compare them with other studies as available in literature.

Methods: 30 patients with tibial plateau fractures treated by various surgical modalities at Saveetha Medical College and Hospital were studied from January 2013 to February 2015 and were followed up for a minimum period of 6 months. Functional and radiological outcomes were assessed by the Rasmussens scoring system.

Results: All 30 patients fulfilling the inclusion criteria were thoroughly evaluated and were taken up for surgery with various modalities of fixation which included cannulated cancellous screws, T and L buttress plates and locking compression plates. Articular surface elevation with bone grafting was done in depressed fractures. Early knee mobilization was started and strict non-weight bearing walking was advocated. We had a 90% acceptable functional result which was comparable with other studies.

Conclusions: In our study, we conclude that accurate reduction of the articular surface with stable internal fixation and early mobilization with bone grafting in depressed fractures with protracted weight bearing till fracture union gives good functional results. Also radiological values often do not often correlate well with functional outcomes. 
A prospective study of treatment of distal femur fractures with locking condylar plate
Authors: Bhanu Rekha Y. , Brahmananda Reddy N.
Published: October 2017

Background: Multiple implants are available to treat distal femoral fractures. The recent addition is the locking plate contoured to the distal femur with combiholes in the proximal portion. Though it is established that locking plates offer higher stability than the previous implants like dynamic compression screw or condylar buttress plate, some studies showed higher incidence of delayed union. We evaluated 30 type A and type C distal femoral fractures treated with locking condylar plate in our institutes.

Methods: We conducted a prospective study on 30 consecutive patients with fractures of distal femur operated with locking condylar plate from December, 2015 to February, 2017. Patients were regularly followed up with x-rays and clinical examination. At the end of one year follow-up, patients were evaluated with Pritchett score.

Results: Fracture union was seen in all patients. Union was faster in type A fractures than in type C intra articular fractures. 67% of patients achieved excellent to good grading according to Pritchett rating system.

Conclusions: Locking condylar plate is effective in treating distal femoral fractures with minimal complications.
Optimal energy recovery by means of pumps as turbines (PATs) for improved WDS management
Authors: Tricarico Carla , Morley Mark S. , Gargano Rudy , Kapelan Zoran , Savić Dragan , Santopietro Simone , Granata Francesco , de Marinis Giovanni
Published: October 2017

In water networks characterized by a significant variation in ground elevations the necessity of pumping water in some areas is complicated by a conflicting requirement to reduce excess pressures in other areas. This and the increasing cost of electricity has led to the use of Pumps-operating-As-Turbines (PATs) devices that can reduce pressure (and leakage) whilst harvesting energy. This paper presents a methodology for optimal water distribution system (WDS) management, driving the optimization by minimizing the surplus pressure at network nodes and the operational pumping costs and maximizing the income generated through energy recovery. The method is based on a highly parallelized Evolutionary Algorithm, employing an hydraulic solver to evaluate hydraulic constraints. Water demands at network nodes are considered as uncertain variables modelled by using a probabilistic approach in order to take into account unknown future demands. The approach is demonstrated in different case studies. Results obtained highlight that the economic benefits of installing PATs for energy recovery in conjunction with a combined pump-scheduling and pressure management regime is especially related to the input network characteristics. Further analysis of the importance of the probabilistic approach and of the influence of the interval time step adopted for the optimization has been evaluated.
Desarrollo y evaluación de un método racional y no destructivo para la toma de muestras de maderas blandas utilizadas en análisis químicos
Authors: Musule Lagunes Ricardo , Bárcenas Pazos Guadalupe Martha , Pineda López María del Rosario , Houbron Eric Pascal , Sánchez Velásquez Lázaro Rafael
Published: October 2017

La madera ha sido un recurso natural ampliamente utilizado por la humanidad. Particularmente, la madera de coníferas destaca por su importancia ecológica, económica y distribución geográfica en comparación con otros taxa. Algunos usos de las diferentes especies maderables se basan en la evaluación de sus propiedades físicas, así como en el análisis de sus principales propiedades químicas. Para esto último, es deseable una metodología óptima para la toma de muestra de madera (TMM) en árboles en pie. Estas metodologías son escasas y pocas consideran anticipadamente en conjunto, tanto la cantidad necesaria de madera para las determinaciones químicas (toma de muestra racional) como también una toma de muestra no destructiva (sin talar los árboles). Por esta razón el objetivo del presente estudio fue desarrollar una metodología paso a paso que describa la TMM de coníferas de forma racional y no destructiva. La metodología TMM se evaluó en Abies religiosa a lo largo de diferentes sitios de muestreo y consiste en cuatro pasos: 1) Definir la cantidad de madera necesaria; 2) Determinar la densidad básica de la madera (parámetro más importante en la precisión de posteriores cálculos); 3) Calcular el volumen a extraer y 4) Tomar las muestras de madera en campo. Los resultados mostraron que la cantidad de madera de A. religiosa obtenida con la metodología fue mayor a la necesaria, sin presentar diferencias significativas (P ˃ 0.05) entre los sitios de muestreo. En conclusión, la metodología fue exitosa para esta conífera, sin embargo, se requieren estudios posteriores para determinar si podrá aplicarse en otras especies de maderas de coníferas.
Cultural and Contextual Adaptation of an eHealth Intervention for Youth Receiving Services for First-Episode Psychosis: Adaptation Framework and Protocol for Horyzons-Canada Phase 1 (Preprint)
Authors: Lal Shalini , Gleeson John , Malla Ashok , Rivard Lysanne , Joober Ridha , Chandrasena Ranjith , Alvarez-Jimenez Mario
Published: October 2017

BACKGROUND

eHealth interventions have the potential to address challenges related to access, service engagement, and continuity of care in the delivery of mental health services. However, the initial development and evaluation of such interventions can require substantive amounts of financial and human resource investments to bring them to scale. Therefore, it may be warranted to pay greater attention to policy, services, and research with respect to eHealth platforms that have the potential to be adapted for use across settings. Yet, limited attention has been placed on the methods and processes for adapting eHealth interventions to improve their applicability across cultural, geographical, and contextual boundaries.

OBJECTIVE

In this paper, we describe an adaptation framework and protocol to adapt an eHealth intervention designed to promote recovery and prevent relapses in youth receiving specialized services for first-episode psychosis. The Web-based platform, called Horyzons, was initially developed and tested in Australia and is now being prepared for evaluation in Canada.

METHODS

Service users and service providers from 2 specialized early intervention programs for first-episode psychosis located in different provinces will explore a beta-version of the eHealth intervention through focus group discussions and extended personal explorations to identify the need for, and content of contextual and cultural adaptations. An iterative consultation process will then take place with service providers and users to develop and assess platform adaptations in preparation for a pilot study with a live version of the platform.

RESULTS

Data collection was completed in August 2017, and analysis and adaptation are in process. The first results of the study will be submitted for publication in 2018 and will provide preliminary insights into the acceptability of the Web-based platform (eg, perceived use and perceived usefulness) from service provider and service user perspectives. The project will also provide knowledge about the adaptations and process needed to prepare the platform for evaluation in Canada.

CONCLUSIONS

This study contributes to an important gap in the literature pertaining to the specific principles, methods, and steps involved in adapting eHealth interventions for implementation and evaluation across a diverse range of cultural, geographical, and health care settings.
Person-Generated Health Data in Simulated Rehabilitation Using Kinect for Stroke: Literature Review (Preprint)
Authors: Dimaguila Gerardo Luis , Gray Kathleen , Merolli Mark
Published: October 2017

BACKGROUND

Person- or patient-generated health data (PGHD) are health, wellness, and clinical data that people generate, record, and analyze for themselves. There is potential for PGHD to improve the efficiency and effectiveness of simulated rehabilitation technologies for stroke. Simulated rehabilitation is a type of telerehabilitation that uses computer technologies and interfaces to allow the real-time simulation of rehabilitation activities or a rehabilitation environment. A leading technology for simulated rehabilitation is Microsoft’s Kinect, a video-based technology that uses infrared to track a user’s body movements.

OBJECTIVE

This review attempts to understand to what extent Kinect-based stroke rehabilitation systems (K-SRS) have used PGHD and to what benefit.

METHODS

The review is conducted in two parts. In part 1, aspects of relevance for PGHD were searched for in existing systematic reviews on K-SRS. The following databases were searched: IEEE Xplore, Association of Computing Machinery Digital Library, PubMed, Biomed Central, Cochrane Library, and Campbell Collaboration. In part 2, original research papers that presented or used K-SRS were reviewed in terms of (1) types of PGHD, (2) patient access to PGHD, (3) PGHD use, and (4) effects of PGHD use. The search was conducted in the same databases as part 1 except Cochrane and Campbell Collaboration. Reference lists on K-SRS of the reviews found in part 1 were also included in the search for part 2. There was no date restriction. The search was closed in June 2017. The quality of the papers was not assessed, as it was not deemed critical to understanding PGHD access and use in studies that used K-SRS.

RESULTS

In part 1, 192 papers were identified, and after assessment only 3 papers were included. Part 1 showed that previous reviews focused on technical effectiveness of K-SRS with some attention on clinical effectiveness. None of those reviews reported on home-based implementation or PGHD use. In part 2, 163 papers were identified and after assessment, 41 papers were included. Part 2 showed that there is a gap in understanding how PGHD use may affect patients using K-SRS and a lack of patient participation in the design of such systems.

CONCLUSIONS

This paper calls specifically for further studies of K-SRS—and for studies of technologies that allow patients to generate their own health data in general—to pay more attention to how patients’ own use of their data may influence their care processes and outcomes. Future studies that trial the effectiveness of K-SRS outside the clinic should also explore how patients and carers use PGHD in home rehabilitation programs.
Strengths-Based Behavioral Intervention for Parents of Adolescents With Type 1 Diabetes Using an mHealth App (Type 1 Doing Well): Protocol for a Pilot Randomized Controlled Trial (Preprint)
Authors: Hilliard Marisa E , Eshtehardi Sahar S , Minard Charles G , Saber Rana , Thompson Debbe , Karaviti Lefkothea P , Rojas Yuliana , Anderson Barbara J
Published: October 2017

BACKGROUND

Supportive parent involvement for adolescents’ type 1 diabetes (T1D) self-management promotes optimal diabetes outcomes. However, family conflict is common and can interfere with collaborative family teamwork. Few interventions have used explicitly strengths-based approaches to help reinforce desired management behaviors and promote positive family interactions around diabetes care.

OBJECTIVE

The aim of this protocol was to describe the development of a new, strengths-based behavioral intervention for parents of adolescents with T1D delivered via a mobile-friendly Web app called Type 1 Doing Well.

METHODS

Ten adolescent-parent dyads and 5 diabetes care providers participated in a series of qualitative interviews to inform the design of the app. The 3- to 4-month pilot intervention will involve 82 parents receiving daily prompts to use the app, in which they will mark the diabetes-related strength behaviors (ie, positive attitudes or behaviors related to living with or managing T1D) their teen engaged in that day. Parents will also receive training on how to observe diabetes strengths and how to offer teen-friendly praise via the app. Each week, the app will generate a summary of the teen’s most frequent strengths from the previous week based on parent reports, and parents will be encouraged to praise their teen either in person or from a library of reinforcing text messages (short message service, SMS).

RESULTS

The major outcomes of this pilot study will include intervention feasibility and satisfaction data. Clinical and behavioral outcomes will include glycemic control, regimen adherence, family relationships and conflict, diabetes burden, and health-related quality of life.

CONCLUSIONS

This strengths-based, mobile health (mHealth) intervention aims to help parents increase their awareness of and efforts to support their adolescents’ engagement in positive diabetes-related behaviors. If efficacious, this intervention has the potential to reduce the risk of family conflict, enhance collaborative family teamwork, and ultimately improve diabetes outcomes.

CLINICALTRIAL

ClinicalTrials.gov NCT02877680; https://clinicaltrials.gov/ct2/show/NCT02877680 (Archived by WebCite at http://www.webcitation.org/6xTAMN5k2)