bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, synthesis, insilco study and biological evaluation of new isatin-sulfonamide derivatives by using mono amide linker as possible as histone deacetylase inhibitors
Authors: Alibeg Ammar Abdul Aziz , Mohammed Mohammed Hassan
Published: April 2024

Aim: To evaluate the cytotoxic activity of newly synthesized a series of novel HDAC inhibitors comprising sulfonamide as zinc binding group and Isatin derivatives as cap group joined by mono amide linker as required to act as HDAC inhibitors.
Materials and Methods: The utilization of sulfonamide as zinc binding group joined by N-alkylation reaction with ethyl-bromo hexanoate as linker group that joined by amide reaction with Isatin derivatives as cap groups which known to possess antitumor activity in the designed of new histone deacetylase inhibitors and using the docking and MTT assay to evaluate the compounds.
Results: Four compounds have been synthesized and characterized successfully by ART-FTIR, NMR and ESI-Ms. the compounds were synthesized and characterized by successfully by ART-FTIR, NMR and ESI- Ms. Assessed for their cytotoxic activity against human colon adenocarcinoma MCF-7 (IC50, I=105.15, II=60.00, III=54.11, IV=56.57, vorinostat=28.41) and hepatoblastoma HepG2 (IC50, I=63.91, II=135.18, III=118.85, IV=51.46, vorinostat=37.50). Most of them exhibited potent HDAC inhibitory activity and significant cytotoxicity.
Conclusions: The synthesized compounds (I, II, III and IV) showed cytotoxicity toward MCF-7 and HepG2 cancer cell lines and their docking analysis provided a preliminary indication that they are viable [HDAC6] candidates.
Physicochemical properties as a function of lomefloxacin biological activity
Authors: Naser Noor H. , Suhail Falah S.A. , Hussein Sahar A. , Salih Shakir Shinawa
Published: April 2024

Aim: The goal is to discover QSAR of Lomefloxacin as antibacterial activity.
Materials and Methods: A number of lomefloxacins analogs activities were studied by program Windows Chem SW. The analogues were obtained and energy minimization was carried out through Molecular Modeling Program, the calculations were performed using General Atomic and Molecular Electronic Structure System (GAMESS) software.
Results: There were six descriptions (N-quinoline more (-) ev charge, Kinetic Energy, Potential Energy, Log p, Log S, F6 charge) results have highly compatible of physicochemical properties with lomefloxacin analogs activities. It can be used to estimate the activities depending on QSAR equation of lomefloxacin analogs.
Conclusions: The parameters used for calculation were depending on the quantum chemical was employed in deriving from computational study of properties and can used to predict the activities of certain analogs of Lomefloxacins as antibacterial compounds.
Comparative study of oral microbiota in the experimental long-term opioid exposure, after its withdrawal and the use of complex drug correction
Authors: Fik Volodymyr B. , Krynytskyi Roman P. , Dudok Olha V. , Podolіyk Мariіa V. , Kosiuta Myroslava A. , Fedoniuk Larysa Ya.
Published: April 2024

Aim: To study changes of dental biofilm microbiota composition during experimental opioid exposure, after its withdrawal and when using of complex drug correction.
Materials and Methods: Microbiological studies (48 rats) included microscopic and bacteriological methods, as well as determination of antibiotic susceptibility of microbial isolates. Ceftriaxone and pentoxifylline were used to correction the changes.
Results: The action of opioid for 10 weeks caused considerable changes in the microbiocenosis, which was illustrated by a significant increasing of the opportunistic pathogens quantitative indicators and the emergence of pathogenic microbiota. Changes in the microbiocenosis at 6 weeks of opioid exposure and after its withdrawal for 4 weeks were expressed in the appearance of pathogenic microbiota and the absence of significant differences in quantitative indicators of saprophytic and opportunistic microflora compared to similar indicators in animals with 10 weeks opioid exposure. This indicated a slow progression of dysbiotic changes and the inflammatory process in the oral cavity of rats.
Conclusions: After 10 weeks of experiment with opioid administration for 6 weeks and the use of ceftriaxone and pentoxifylline on the background of 4-week opioid withdrawal, a significant reduction of quantitative indicators of opportunistic bacteria and elimination of pathogenic species of microorganisms was determined. The use of complex drug correction on the background of 10 weeks of opioid exposure led to a significant reduction in the quantitative indicators of opportunistic pathogens and contributed to the elimination of most pathogenic species of microbiota under the action of ceftriaxone.
Immunohistochemical study of CD74 biomarker in normal and malignant breast tissues
Authors: Hassan Hayder Neamah , Al-Hussein Rouaida Kadhim A. , Al-Naqeeb Asmehan Adnan
Published: April 2024

Aim: To detect the role of CD74 expression in breast carcinoma as a predictive marker for identifying the biological behavior of malignancy in Iraqi women.
Materials and Methods: The study used technique of immunohistochemistry for detection CD74 protein role in breast cancer, and its expression in breast cancer tissue samples. Samples were collected in Al-Najaf city in Iraq, from Al-Forat Al-Awsat Oncology Center. The study was achieved at the Laboratories of the Faculty of Science in the University of Kufa. Fifty samples of breast cancer tissue, and twenty controls benign tissue were included in the study. The study has investigated relationship between expression of biomarker with grade, age of patient and tumor size.
Results: The study showed that the cytoplasmic expression of CD74 with more clear and intensive staining in the cytoplasm, and reported that CD74 positivity rate was 52%. A significant association between CD74 expression and grade and size of tumor, so CD74 can be considered as a biomarker for prediction of breast cancer in women. No association was found between CD74 expression and each of patients’ age and node metastasis.
Conclusions: The study represents an important step in our region because there are a few studies about this topic; more efforts are required to approve the function of this biomarker.
The right to know from the opt-out effectiveness system perspective in organ transplantation cases
Authors: Kokina Daniela , Palkova Karina
Published: April 2024

Aim: This article examines the legal challenges associated with opt-out and opt-in systems in transplantation cases. It focuses on the low public knowledge and awareness of the national transplantation system, assessing its compliance with international prerequisites for an opt-out system. The analysis centres on the “right to know” perspective and the effectiveness of opt-out in organ transplantation.
Materials and Methods: The research methodology includes scientific principles, public surveys, relevant regulations from the Republic of Latvia and EU, and grey literature on the health system and organ donation in the EU. Scientific articles from databases such as Scopus and WOS were selected based on criteria such as language (English and Latvian) and focus on living wills and comparisons of organ donation systems. Previous EU and national studies, reports, and court judgments were used to analyse data on opt-in and opt-out transplantation systems and policy efficiency in organ transplantation.
Conclusions: Individuals’ right to autonomy over their bodies extends even after death, encompassing the right to integrity. Organ donation, being a deeply personal choice reflecting one’s values and beliefs, plays a crucial role in saving lives through transplantation. To enhance cooperation and donation rates, international regulations stress the significance of public awareness regarding organ and tissue transplantation. Unfortunately, inadequate compliance by authorities and low awareness pose ethical and legal dilemmas, potentially violating constitutional rights. Reports highlight limited public understanding of transplantation systems, raising concerns, particularly in opt-out systems. National governments bear the responsibility of safeguarding these rights and addressing challenges beyond legal means, thus establishing a more ethical organ donation system that upholds voluntariness, generosity, and individual autonomy.
Current issues and challenges of russian legal statistics
Authors:   O. E. Kutafin Moscow State Law University (MSAL), Tsybulchenko Sofia P.
Published: April 2024

The article examines current issues and challenges of legal statistics in Russia. In modern Russia, statistics play a key role in the development of all aspects of public administration and the legal system, where the accuracy, objectivity and completeness of the collected data become the cornerstones for making informed decisions, forming legal policy and effectively regulating public relations. The use of advanced statistical analysis methods and improving the quality of statistical data will not only increase the effectiveness of law enforcement and judicial proceedings, but also contribute to strengthening the legal system, increasing public confidence in authorities and the judicial system.
Migrationsgeschichten: Ein didaktischer Ansatz in der interkulturellen Pädagogik
Authors: Steiner-Khamsi Gita
Published: April 2024

Im vorgestellten didaktischen Ansatz der Interkulturellen Pädagogik wird die Wanderungsgeschichte der eigenen Familie als Ausgangsmaterial verwendet, um das eigene Kultur- und Heimatverständnis zu reflektieren. Wie die in der Lehrerbildung mehrmals angewandte Übung aufzeigt, besteht bei den Betroffenen keineswegs Übereinstimmung, was "schweizerische Kultur" sein soll. Auch ist das eigene Heimatverständnis weitgehend ungeklärt. Dementsprechend wird angeregt, die Kulturfrage bezüglich der ausländischen Schülerschaft zu relativieren und sich stattdessen mit der Lebenssituation ausländischer Familien auseinander zu setzen.
Using transect sampling and road cruising surveys to estimate abundance and distribution of sidewinders (Crotalus cerastes) in Saguaro National Park, Tucson Mountain District: Final report
Authors: Gardner Coral , Goode Matt , Philippi Tom , Swann Don
Published: April 2024

Saguaro National Park, Tucson Mountain District (TMD) includes a portion of the Tucson Mountains and adjacent lower bajada landscapes along the western boundary in Avra Valley. Threats to TMD include urban encroachment, busy commuter roads running through the interior and along the boundaries, agricultural development, and the Arizona Canal and water recharge basin. Plans to route Interstate 11 within 400 m of the western boundary have led to concerns over projected negative impacts on wildlife. Among the species of concern is the Sidewinder (Crotalus cerastes), primarily because the population residing in TMD represents the easternmost distribution of this iconic species. Historical records are limited to a handful of localities; however, given their cryptic lifestyle, and the lack of intensive survey effort, there was a need to determine if the species is truly rare or just apparently rare but difficult to detect.

To better inform management, we used distance sampling along transects and washes and road cruising surveys to examine density and distribution of Sidewinders in TMD. From May-September, 2022, encompassing both the dry pre-monsoon season and the wet monsoon season, we conducted 519 distance sampling surveys totaling 814.61 km and 69 road cruising surveys totaling 1,997.47 km in upland and wash environments.

Our efforts produced 421 total snake observations, which included only nine Sidewinder observations. The small number of Sidewinders observations proved to be insufficient for model convergence. Although we were unable to obtain density estimates of Sidewinders, data from both distance sampling and road cruising surveys provided valuable information on distribution of the species. As expected, we only observed Sidewinders in the westernmost portion of TMD in sandy environments dominated by yellow palo verde and creosote bush. Because we observed a relatively large number (n = 229) of Western Diamond-backed Rattlesnakes (Crotalus atrox), the most commonly observed species, we were able to obtain robust density estimates, which has rarely been done for snakes of any kind.

Results revealed that C. atrox density varied by season, with more than double the number of detections during the rainy monsoon season, compared to the dry pre-monsoon season. We recommend that TMD staff conduct repeated road cruising surveys over time to make inferences about population trends that can be compared before and after construction of I-11.
Comparative Carbon Stock Potential of Indigenous Agroforestry Systems in Silte Wereda, Southern Ethiopia
Authors: Semere Mihert , Tadesse Chala , Abebe Tesemash , Cherinet Abirham , Gebreyesus Marta
Published: April 2024

Agroforestry system (AFS) is described as one of the promising mitigation options for climate change through its high carbon sequestration capacity. This study was conducted in Silite District; Southern Ethiopia to assess the unaccounted carbon stock potential of selected traditional agroforestry systems. The study assessed the carbon stock potential of AFS biomass and soil carbon pools. Biomass and soil samples were taken from temporary plots laid for this study, 20 × 20 m for home garden, 50 × 100 m for parkland, and 10 × 10 m for woodlot AFS. Height (H) and diameter at breast height (DBH) were taken from the sample plots to estimate biomass carbon. Litter, herb, and grass samples were collected from 1 m2 quadrant within the main plot. The findings show that the total biomass carbon ranged from (1.28-7 Mg ha -1) though there was no significant difference among the systems and higher biomass carbon was attributed by parkland AFS while the lowest was woodlot. A significantly higher amount of SOC was recorded in home garden AFS along the two depths (82.5 Mg ha -1) than the other two systems and the lowest was attributed to parkland (41.7 Mg ha -1). Therefore, this traditional AFS should be supported for their contributions in climate change mitigation schemes as they can sequester a reasonable amount of carbon
Effect of Preoperative Nutritional Status on Clinical Outcome After Surgery for Early-Stage Non-Small Cell Lung Cancer
Authors: Lu Kaiming , Pan Xiongfeng , Zheng Jinyu , Cheng Dezhi , Zheng Liangcheng , Zhang Xinbo
Published: April 2024

This study aimed to determine whether preoperative nutritional status affects surgical outcomes in patients with early-stage non-small cell lung cancer. This cross-sectional study included 80 patients scheduled for non-small cell lung cancer surgery. Patients with protein-energy malnutrition were identified using recent weight loss, serum albumin levels, and total lymphocyte count. Recovery time, complication rates, and overall survival were evaluated as surgical outcomes using logistic regression, Cox proportional hazards models, and Kaplan–Meier survival analysis. We found that preoperative nutritional status was a substantial predictor of surgical outcomes. Well-nourished patients had 2.5 times lower surgical success rates and considerably lower incidences of adverse events than those who were severely malnourished. Additionally, malnutrition was correlated with prolonged hospital stays and recovery periods. Kaplan–Meier analysis of survival shows that well-nourished patients had a considerably longer survival period. The independent predictive power of nutritional status over postoperative outcomes was validated using multivariate analysis, highlighting the importance of implementing focused nutritional interventions. We demonstrated the importance of preoperative nutritional evaluations and interventions in enhancing survival, reducing complications, and improving surgical success rates among patients with non-small cell lung cancer. Incorporating nutritional support into preoperative care protocols substantially affected the clinical outcomes of patients undergoing non-small cell lung cancer surgery.
Hubungan Tingkat Stres Dengan Perubahan Pola Haid Pada Mahasiswi Tingkat Akhir Stikes Panrita Husada Bulukumba Dan Universitas Muhammadiyah Bulukumba
Authors: Tenriwati  , Haerati  , Nurhalisa
Published: April 2024

Stres menyebabkan pelepasan hormon kortisol dimana hormon kortisol berfungsi sebagai titik acuan untuk menilai tingkat stres seseorang. Stres merangsang aksis HPS yang memproduksi hormon kortisol yang dapat mengakibatkan ketidakseimbangan homon resproduksi dan terjadi gangguan pola haid. Pola haid yang normal yaitu lama haid :2-3 hari, volume haid :35-80cc/hari, siklus haid 25-35 kali/hari dan mengganti pembalut : 2-3 kali/hari.

Tujuan  :  diketahuinya Hubungan Tingkat Stres Dengan Perubahan Pola Haid Mahasiswi Tingkat akhir STIKES Panrita Husada Bulukumba dan Universitas Muhammadiyah Bulukumba.

Metode  : Penelitian ini adalah penelitian kuantitatif dengan pendekatan cross sectional. Populasi pada penelitian ini yaitu 75 orang dengan besar sampel 52 orang.

Hasil      : Hasil penelitian yaitu setelah dilakukan uji statistik dengan uji Fisher’s didapatkan hasil p=0,000, maka disimpulkan bahwa ada  hubungan signifikan antara tingkat stres dengan perubahan pola haid mahasisiwi tingkat akhir di Stikes Panrita Husada Bulukumba. Dan didapatkan p=0,001 dengan uji Fisher’s, maka disimpulkan bahwa ada hubungan antara tingkat stres dengan perubahan pola haid mahasiswi tingkat akhir di universitas muhammadiyah bulukumba.

kesimpulan dan saran :  Ada  hubungan tingkat stres dengan perubahan pola haid mahasiswi tingkat akhir Stikes Panrita Husada Bulukumba dan Universitas Muhammadiyah Bulukumba. Mahasiswi tingkat akhir mampu mengontrol dan mengatasi stres yang dialaminya selama penyusunan tugas akhir agar pola haidnya tetap teratur.
Midwifery care during the postpartum period for Ny "A" at Bontobangun Community Health Center, Rilau Ale District, Bulukumba Regency
Authors: Eka Juniarli Sri , Nabila  , Murida Wiriyanti
Published: April 2024

Postpartum is a normal process, but this situation can turn abnormal if it is not monitored. Complications that can occur are one of the causes of irregular PNC visits. So comprehensive midwifery care is needed, where this care is expected to be able to minimize complications that can occur during postpartum and it is hoped that the mother can go through all the processes normally, the aim is to provide comprehensive care to the child. NY “A” is 26 years old. The method used is a case study with a Varney midwifery management approach with data collection techniques including observation, interviews, physical examination and documentation studies. The results of comprehensive midwifery care in NY "A" with normal postpartum were known from the results of observations which indicated that there were no problems since midwifery care was carried out from the first postpartum visit to the fourth postpartum visit. Conclusion: Comprehensive midwifery care in NY "A" was carried out according to midwifery care standards with normal results without any complication

 

Keyword :  Comprehensive; Midwifery
Numerical Examination of a Squeezing Casson Hybrid Nanofluid Flow Considering Thermophoretic and Internal Heating Mechanisms
Authors: El Harfouf Amine , Herbazi Rachid , Abouloifa Walid , Mounir Sanaa Hayani , Mes-Adi Hassane , Wakif Abderrahim , Mejdal Mohamed , Nfaoui Mohamed
Published: April 2024

One of the main areas of study in the field is increasingly the flow of non-Newtonian fluids. These liquids find extensive use in nuclear reactors, food processing, paint and adhesives, drilling rigs, and cooling systems, among other industrial and engineering domains. However, hybrid nanofluids are crucial to the process of heat transfer. Considering this, this study investigates the motion of a Casson hybrid nanofluid squeezing flow between two parallel plates under the influence of a heat source and thermophoretic particle deposition. The Runge–Kutta–Fehlberg fourth–fifth-order approach is utilized to numerically solve the ordinary differential equations derived from the partial differential equations governing fluid flow, by utilizing suitable similarity variables. The diagrams show how several important parameters affect fluid profiles both with and without the Casson parameter. These figures demonstrate how fluid velocity increases as the local porosity parameter increases. When the heat source/sink parameter is increased, thermal dispersal increases, and when the thermophoretic parameter is increased, the concentration profile increases.
Efficacy of interleukin-6 inhibitors as a tool for preventive anti-inflammatory therapy for COVID-19
Authors: Zyryanov S. K. , Butranova O. I. , Abramova A. A.
Published: April 2024

The novel coronavirus infection (COVID-19) is characterized by damage, along with the lungs, to many other vital organs and systems. The prevalence and severity of the resulting lesions are determined by the ability of the SARS-CoV-2 virus to cause excessive activation of the immune response, accompanied by changes in both cellular and humoral components. Among humoral disorders, the most significant is the hypersecretion of cytokines, including interleukins (IL), in particular IL-6 and IL1β. Elevated levels of IL-6 are one of the main predictors of severe COVID-19 and death. So, blocking the effects of this cytokine is of fundamental importance for improving the clinical outcomes of patients. Monoclonal antibodies against human interleukin-6 receptor or against IL-6 have been widely studied in patients with extremely severe COVID-19, and to a lesser extent in mild and moderate severity. Regardless of the severity, maximum effectiveness is achieved when these drugs are administered as early as possible, which made it possible to create such a tool as preventive anti-inflammatory therapy. Preventive prescription of IL-6 inhibitors may be useful not only for hospitalized inpatients, but also for outpatients. This review is aimed to assess the effectiveness of early use of IL-6 inhibitors both in hospitalized and ambulatory patients with varying degrees of severity of COVID-19.
THEORETICAL ESTIMATION OF AFEM AS NEW NUMERICAL METHOD FOR ANALYSIS OF N-NONLINEAR SYSTEMS AT LIMIT STATES.
Authors:   Federal State Autonomous Educational Institution of Higher Education, Ermakova A.V.
Published: April 2024

The paper presents the theoretical estimation of Additional Finite Element Method (AFEM) from the point of view of the Numerical Method Theory. AFEM is the variant of Finite Element Method (FEM). This variant extends FEM abilities for analysis of N-nonlinear systems under the growth of applied load and the number of physical nonlinear properties. Mathematical modeling process realizes by introduction of additional finite elements (AFE-s) into additional design diagrams (ADD-s). This helps the gradual transformation of main set of equations at every step of analysis. The last step is the limit state moment of considered system, when their design diagram transmits into ideal failure model (IFM).
SOCIO-LEGAL FOUNDATIONS OF EDUCATION OF ETHNO-CULTURAL TOLERANCE IN THE "CONCEPT OF STATE POLICY OF THE REPUBLIC OF UZBEKISTAN IN THE FIELD OF INTERETHNIC RELATIONS"
Authors:   Samatkand State Medical University, Uzbekistan, Sayfullayevich Tangirov Eldor
Published: April 2024

In this article, the study and coverage of the socio-legal foundations implemented in our country in the formation of ethno-cultural tolerance in students.
Síndrome de Stokes Adams en paciente con Marcapasos: Reporte de Caso y Revisión del Abordaje en su Falla
Authors: Nolasco Amezcua Jorge , Borrero Colmenares Rebecca , Rincón Gallardo Francisco Lugo , Olvera Zetina Dante
Published: April 2024

El síndrome de Stoke Adams se define como pérdida súbita transitoria del estado de alerta asociada a crisis convulsivas secundario a bajo gasto principalmente causado por defectos de la conducción intracardiaca como bloqueo auriculoventricular de tercer grado, fibrilación ventricular y bradicardia. Otras etiologias menos frecuentes son defecto progresivo de la conducción intracardiaca (Antes enfermedad de Lenegrè-Lev), intoxicación por antimonio, miocarditis, fiebre reumática y anomalías congénitas como anomalía de Ebstein. Existen estrategias para el manejo del síndrome de Stoke-Adams que incluyen la corrección de los posibles factores que contribuyen a la enfermedad como acidosis metabólica e hipercalemia, sin embargo, el tratamiento definitivo es la colocación de marcapasos. Presentamos el caso de una paciente que debuta con síndrome de Stoke-Adams secundario a falla en la captura de marcapasos colocado por bloqueo auriculoventricular completo, la cual eventualmente evoluciono a taquicardia ventricular sin pulso, recuperando la circulación espontanea con 1 ciclo de reanimación cardiopulmonar. La causa de disfunción del marcapasos se dio por falla en la captura, se ajustó su configuración, logrando la entrada del estímulo. En este texto revisamos la asociación de la dextrocardia con ciertas arritmias, puntualizamos singularidades de la colocación de marcapasos en la dextrocardia, diagnóstico de bloqueo AV (auriculoventricular) de tercer grado y el abordaje diagnóstico en la disfunción de marcapasos.
Habilidades Emocionales y Convivencia Escolar: Un Análisis en Estudiantes de Tercero a Quinto de Primaria
Authors: Correal Gutiérrez Monica , Vega Granda Ricardo
Published: April 2024

La presente investigación se centra en la relación entre habilidades emocionales y convivencia escolar en estudiantes de tercer a quinto año de primaria en la unidad de planeación zonal de Britalia, Kennedy. Se emplearon el Tests THInEmE de Merchán Romero (2017) y la escala de Convivencia de Sánchez (2020) para analizar una muestra de 442 estudiantes de dos escuelas públicas en Bogotá. La metodología fue confirmatoria y no experimental, con diseño de campo y control de variables. Se encontró una estrecha asociación entre habilidades emocionales y convivencia escolar, lo que destaca la influencia de la percepción, facilitación, comprensión y regulación emocional en las siete sinergias de la convivencia escolar. Se concluye que intervenir de forma temprana para cultivar estas habilidades y mejorar la convivencia es crucial, se resalta el papel de los docentes y directivas en la viabilización de estos procesos. Los análisis revelaron un panorama desafiante en la convivencia escolar en los colegios MCV (SEDE A y B) y CLASS, donde solo el 7,50% de los estudiantes mantuvieron niveles armoniosos. Estos hallazgos sugieren la necesidad de abordar las habilidades emocionales de forma sistematica en las escuelas, desde los planes de estdudio e implementar estrategias específicas para apoyar a los estudiantes más pequeños, lo que iria en pro de mejorar la convivencia en estos entornos educativos.
Desafíos en la Gestión Integral del Agua en la Comunidad Cedro de la Manzana, Estado de México
Authors: Martinéz Narciso Domingo , Cárdenas Camargo Israel
Published: April 2024

La gestión efectiva del agua busca el equilibrio entre las dimensiones social, económica, política y ambiental. Así, los objetivos de este trabajo fueron, documentar la problemática en la gestión del agua en la comunidad Cedro de la Manzana y sugerir una serie de propuestas que permitan mejorar esta gestión llevando a un escenario de sustentabilidad. Esta comunidad rural-indígena, se localiza en la zona norte del Estado de México, México y desafortunadamente cuanta con uno de los índices de Desarrollo humano mas precarios de esta entidad. La metodología utilizada fue el método etnográfico, aplicando un cuestionario sobre la gestión del agua a colaboradores claves. Las principales problemáticas identificadas en la comunidad resaltadas por el cuestionario y documentadas fueron desabasto, mala distribución, falta de mantenimiento de la infraestructura y deficiencia en el almacenamiento del recurso. Las propuestas para atender estas problemáticas fueron organizadas a nivel comunidad y a nivel familiar. Finalmente, el analizar los escenarios locales y el generar propuestas focalizadas puede contribuir a promover el desarrollo local sustentable.
Estudio de Caso: Mejora Técnica Instrumental en Fragmentos de la Partita 2 de J. S. Bach de un Estudiante de Violín del Conservatorio Superior José María Rodríguez
Authors: Sanango Valarezo Carlos Andrés , Aviles Lopez Diego Joel , Hernández Sarmiento Carlos Felipe , Calle González Lourdes Patricia
Published: April 2024

En el Conservatorio Superior José María Rodríguez (CSJMR), la formación violinística se centra en el perfeccionamiento técnico individual, buscando alcanzar interpretaciones que destaquen por su claridad y expresividad. Frente a los retos que presenta el avanzado repertorio musical, se identificaron dificultades comunes entre los estudiantes, lo cual llevó a la implementación de un estudio de caso concreto. El protagonista de este estudio fue Christian Adrian Tenecela Illescas, un estudiante de primer ciclo, quien enfrentaba obstáculos en su desarrollo musical. A través de sesiones de tutoría personalizadas, se propuso un plan para superar estas barreras, enfocándose en la mejora de su interpretación violinística. Estas tutorías no solo proporcionaron una retroalimentación directa y adaptada a las necesidades específicas de Tenecela, sino que también promovieron el desarrollo de competencias pedagógicas, esenciales para el futuro profesional del estudiante. Durante este proceso educativo, se evaluó el progreso de Christian utilizando una variedad de herramientas y enfoques metodológicos que abarcaron dimensiones académicas, sociales, emocionales y cognitivas, permitiendo un análisis integral de su evolución. La implementación de la prueba T de Student fue clave para verificar las mejoras en el desempeño de Tenecela, arrojando resultados que evidenciaron avances significativos después de la intervención tutorial. Este estudio de caso en el CSJMR resalta la importancia y la efectividad de las intervenciones educativas personalizadas. Los hallazgos no solo mostraron una mejora notable en las habilidades musicales y académicas de Christian, sino también en su desarrollo socioemocional, subrayando el valor de un enfoque individualizado en la educación musical. Así, el caso de Tenecela se convierte en un referente dentro del conservatorio, demostrando cómo la atención personalizada puede catalizar el crecimiento integral de los estudiantes en disciplinas tan exigentes como la música.
Estudio Comparado del Neoconstitucionalismo como Forma de defensa de los Derechos Humanos en Contexto Globalizador en Brasil y México
Authors: Paz Medina Luis Abraham , González Hernández Marisol , Rodriguez Mazariego Carlos Romeo , Pérez De la Rosa José Adolfo , Cardim Alves Alinne
Published: April 2024

Los derechos humanos surgen como una respuesta inmediata a las violaciones de la dignidad de las personas. El ser considerado diferente era visto como un ser menor en dignidad y derechos y en ese diapasón ocurrían innumerables violaciones a los derechos humanos. La persona humana era considerada desechable, un mero objeto de compra y venta, algo superfluo en campos de exterminio. Había diferencias de género y así ocurrieron las más graves violaciones a los derechos humanos de la historia como la esclavitud, el sexismo, el racismo, el nazismo, la homofobia, la xenofobia, la muerte de los niños nacidos con discapacidad y otras prácticas intolerantes que denigran y socaban la dignidad de las personas, así, los derechos humanos emergen para asegurar una vida digna a los individuos. Se destaca, la construcción de los derechos humanos en ámbito internacional, así como su positivización en el ordenamiento jurídico brasileño y mexicano como derechos fundamentales, y el surgimiento del neoconstitucionalismo como forma de defensa de los derechos humanos.
Mycofabrication of Iron Nanoparticles: Applications and Future Prospectus
Authors: Vyas Ruchi , Mathur Manisha , Singh Anuradha , Mathur Nupur
Published: April 2024

This review article is concerned with the environmentally benign manufacturing of nanoparticles using microorganisms, particularly fungi. To create nanoparticles, scientists and researchers have Used a variety of physical and chemical processes and procedures. However, these types of nanoparticles are not environmentally friendly and frequently allow for the release of hazardous substances, which could have a negative impact on both humans and the environment. As a result, it is crucial to develop affordable and eco-friendly nanoparticle synthesis techniques and adopt green syntheses by utilizing natural microorganisms like bacteria, fungi, algae, etc.  Fungi are the main focus for shaping these materials into nanoparticles since they can help cut processing time and manufacture nanoparticles in the proper size and form. They are the favored biological materials as the synthesized nanoparticles are non-toxic, thus energy efficiency is improved along with reduced environmental pollution. This is also the main justification for using fungal microorganisms in the synthesis of nanoparticles to produce ideal and non-toxic materials, which can assist in lessening the effects on the environment, improving energy efficiency, and reducing environmental pollution. The biological mechanism by which fungi synthesize iron nanoparticles, the development of diverse forms of iron nanoparticles by fungi, and the use of novel nanoparticles in the currently emerging industry are the main focus of this review.
IoT-Based Smart Vertical Hydroponic System for Chili Plant
Authors: Nurfatin Athirah Mohd Hatipi  , Suzi Seroja Sarnin  , Mohd Nor Md Tan  , Mohd Rizal Dohad  , Nik Farah Emmyra Nik Kamaruzaman  , Nani Fadzlina Naim  , Azlina Idris
Published: April 2024

Agriculture serves as the primary source of food for the global population, playing a critical role in meeting the nutritional needs of people worldwide. With the projected population reaching 9.7 billion by 2050, ensuring an adequate and sustainable food supply becomes increasingly challenging. Hydroponics, a technique that cultivates plants without soil by delivering mineral nutrients through water, offers a potential solution. Hydroponics requires only 10% of the space and 90% less water compared to conventional farming, enabling year-round production of nearly organic food. Vertical hydroponic systems, which arrange plants in stacked or suspended layers, optimize the use of vertical space and are particularly suitable for indoor and urban agriculture where land is limited. However, these systems require regular maintenance and monitoring, including managing nutrient solution balance, pH levels, water quality, and lighting conditions. This complexity can pose challenges for growers lacking time, resources, or technical expertise. To address these issues and ensure sustainability, an automated monitoring method is proposed for vertical hydroponic farming. This project aims to develop a system that automates the checking and maintenance of nutrient levels in the vertical farming process, monitoring factors such as Electrical Conductivity (EC), pH, liquid level, and water temperature. The integration of automation technologies in vertical hydroponics enhances precision, efficiency, and productivity by reducing labour requirements, optimizing resource utilization, and granting growers greater control over the growing environment. These advancements result in healthier plants, higher yields, and more sustainable agricultural practices.
The Readiness of the Malaysian Construction Industry for E-tendering After COVID-19 Pandemic
Authors: Lee Yee Lin  , Khoo Terh Jing  , Chow Yan Thung  , Ha Chin Yee
Published: April 2024

E-tendering implementation can bring significant benefits such as cost savings, transparency in contract and maximize the efficiency and resources to the construction industry. E-tendering also allows users to participate through internet where this increases the competition, lower down transaction cost and minimize the time consumption and errors in the bidding processes. This study determines the readiness level of E-tendering to the Malaysian construction industry so that the construction industries are capable to overcome the possible issues and enhance their implementation of E-tendering in Malaysia. The research applied mixed methodology. 89 respondents have participated in the questionnaire while five respondents were interviewed in the interview sessions. The results showed that E-tendering organization’s attitudinal readiness has several factors such as foresee the construction tendering practice trends, aware if the introduction of E-tendering is by the government, interested in E-tendering, foresee the increasingly importance of E-tendering to company and good knowledge of IT. The organization’s physical readiness has factors such as software facilities, network access, investment in IT, computer infrastructure and technical staff. The results can be used by policies makers to promote the adoption of E-tendering among the potential practitioners in Malaysia where this can improve the efficiency in construction projects tendering process.
Cleanroom Dashboard System for Time-Reduction Checking of Disk Tester Availability
Authors: Camille Merlin S. Tan  , Lawrence Y. Materum
Published: April 2024

With the vast amount of data being processed and reviewed in production and manufacturing industries nowadays, it takes a lot of time and effort to keep track of their performance metrics. Developing an automation system to improve the overall system performance and reduce man-machine interactions is necessary. Prior to the work, a computer disk drive manufacturing facility checked its fixed-tester availability manually, which made the company unable to optimize its man and machine hours as much as possible. This work proposes a system that displays all the critical information in a dashboard system to address the problem while enabling access to data history logs and further analytic insights. Moreover, the system enables readily accessible fixed-disk tester availability. The outcomes indicate significant improvements, especially in delay reductions, necessary for optimizing man and machine interactions in a fixed-disk testing facility at a leading computer disk drive manufacturer and data storage company at Laguna Technopark.
Effects of Different Growing Medium on Obtaining Bulblets from Bulb Scales in Oriental Lilium 'Siberia' Cultivar
Authors: Sarı Ömer
Published: April 2024

This study was carried out to determine the best medium for obtaining bulblets in the Oriental Lilium 'Siberia' plant using bulb scales and different media. In the research, six different growing mediums were used as growing media: soil (control), peat, soil + peat, perlite, perlite + peat, and peat + sand. In the experiment, the number of bulblets, bulblet width, bulblet length, number of healthy and infected bulb scales, and the time it took for the first bulbs to formation were measured. As a result of the study, the highest number of bulblets (110) were obtained from peat + sand. The growing medium with the highest values of bulblet width (11.38 cm) and bulblet length (16.27 cm) was determined to be peat. The highest number of healthy bulb scales (54) was obtained from perlite medium, and the highest number of infected bulb scales (20) was obtained from soil medium. In terms of the formation time of the first bulblets, perlite medium (15 days) was the growing medium where the earliest bulbs were obtained, and the latest bulblets were obtained from control (soil) and soil + peat (40 days). In general, the quality of bulblets obtained from peat medium was better than that from other mediums. In this regard, peat growing medium is recommended to obtain quality bulblets, and peat + sand is recommended if the number of bulblets is desired to be high.
Comparative Analysis of CDK4/6 Inhibitors (Ribociclib and Palbociclib) combined with Enzalutamide in Triple-negative breast cancer cells
Authors: Keser Murat , Atmaca Harika , Karaca Şaziye Burçak
Published: April 2024

Triple-negative breast cancer (TNBC) is recognized as a challenging subtype due to its poor prognosis. Recent molecular profiling studies have unveiled a significant subset expressing the androgen receptor (AR) subset which may respond to AR-blocking agents, offering a potentially effective treatment strategy. This study aims to investigate the potential synergistic cytotoxic and apoptotic effects of the AR antagonist enzalutamide (ENZA) in combination with CDK4/6 inhibitors palbociclib (PB) or ribociclib (RB) and compare the effectiveness of these combinations in TNBC cells. Results revaled that ENZA in combination with PB or RB induced synergistic cytotoxic cytotoxicity in all tested TNBC cell lines. While synergistic cytotoxic combinations of ENZA with PB did not induce apoptosis in any TNBC cell line, ENZA+RB combinations exhibited a synergistic apoptotic effect. This study suggests that the ENZA+RB combination may be more favorable due to its apoptosis-inducing effect. However, these data need to be further supported by detailed in vivo and clinical studies
Pengaruh Brand Ambassador dan Brand Image terhadap Keputusan Pembelian pada e-commerce Tokopedia
Authors: Sinaga Angelia Azarya , Achmad Fauzi  , Chalta Miraj Sebilqis  , Ghiffari Abiyyu Azra  , Haura Salsabila Zahra  , Leo Andri Yulius Caesar  , Ulya Hariroh  , Gultom Zefanya Valeria Hesli
Published: April 2024

Penelitian ini bertujuan untuk menyelidiki dan menganalisis secara menyeluruh dampak nyata yang dihasilkan oleh Brand Ambassador dan Brand Image terhadap proses pengambilan keputusan pembelian konsumen. Dengan menggunakan metode kuantitatif, pendekatan ini memungkinkan peneliti untuk mengumpulkan data secara sistematis melalui survei dari responden yang memiliki pengalaman praktis menggunakan produk atau layanan yang terkait erat dengan merek tertentu. Dengan mengumpulkan informasi secara langsung dari konsumen yang berinteraksi dengan merek tersebut, penelitian ini bertujuan untuk mengungkap persepsi dan pengaruh nyata yang dimiliki oleh Brand Ambassador (1) dan Brand Image (2) dalam membentuk preferensi dan keputusan pembelian (3) mereka
Eksplorasi Pendidikan Inklusif: Kesetaraan dalam Pembelajaran
Authors: Bahri Saiful , Nuryati Nuryati
Published: April 2024

Equality in learning at Kebangsaan Junior High School with an inclusive education approach. This research employs a qualitative method, including interviews, observations, and Focus Group Discussions (FGD) involving discussions with teachers and students at Kebangsaan Junior High School. The findings of this research indicate that gender equality issues remain a concern within the school environment. Students express experiences related to gender stereotypes, while teachers note challenges in implementing an inclusive approach. School administrators play a role in ensuring the success of inclusive education through supportive policies. To achieve the effectiveness of inclusive education, individual awareness, responsibility, mutual respect, and ongoing training for teachers and school staff are crucial. Thus, inclusive education aims not only to reduce gender discrimination but also to create a learning environment that is safe, comfortable, and supportive of cognitive development for students.
Strategi Prioritas dalam Meningkatkan Kompetensi Penyidik untuk Penanganan Tindak Pidana di Bidang Konservasi Sumber Daya Alam Hayati dan Ekosistemnya
Authors: Hendra Cahyana Asep , Fauzi Achmad , Nurhasanah
Published: April 2024

Perdagangan dan penyelundupan satwa liar marak terjadi yang apabila dibiarkan akan menimbulkan kepunahan. Upaya untuk mencegah terjadinya hal tersebut, diperlukan penyidik yang profesional mampu menangani tindak pidana di bidang konservasi sumberidaya alam hayati. Penelitian ini bertujuan untuk menganalisis strategi prioritas dalam meningkatkan kompetensi Polri dalam penanganan konservasi Sumber Daya Alam hayati di Indonesia. Metode penelitian ini menggunakan kualitatif, yang dimana data dikumpulkan melalui wawancara kepada 5 responden yang berprofesi sebagai regulator (2 orang), akademisi (2 orang) dan praktisi (1 orang), memiliki pengetahuan dan pengalaman yang mendalam di bidang konservasi SDA hayati, lalu hasilnya diolah menggunakan aplikasi superdecision versi 2,0. Selanjutnya, dilakukan analisis menggunakan Analytic Network Process (ANP). Hasil penelitian ini menunjukkan masalah prioritas yang berasal dari faktor internal sebesar 70,1% dan faktor eksternal sebesar 26,2%. Aspek masalah prioritas yang berasal dari faktor internal secara berurutan adalah Sumber Daya Manusia (51,2%) dan Regulasi (36,5%). Strategi prioritas yang berasal dari faktor internal sebesar 68,3% dan faktor eksternal sebesar 29,2%. Aspek strategi prioritas yang berasal dari faktor internal adalah Pelatihan sebesar 55,5% dan Revisi Regulasi sebesar 31,8%.
Pengaruh Disiplin Kerja, Motivasi Kerja dan Budaya Organisasi Melalui Kepuasan Kerja Sebagai Variabel Mediasi Terhadap Pengembangan Karir (Kajian Studi Literatur Manajemen Sumber Daya Manusia)
Authors: Irmigardis Makun  , John E. H. J. FoEh
Published: April 2024

Pengembangan karir merupakan  salah satu upaya untuk mendorong seorang karyawan agar bekerja lebih baik. Artikel ini akan membahas pengaruh disiplin kerja, motivasi kerja dan budaya organisasi terhadap pengembangan karir melalui kepuasan kerja sebagai variabel mediasi. Hasil kajian pustaka dan studi hasil penelitian  sejenis, dapat digunakan dengan metode analisis SEM PLS sehingga diperoleh kesimpulan sebagai berikut: 1). Disiplin kerja mempengaruhi kepuasan kerja; 2). Motivasi kerja mempengaruhi kepuasan kerja; 3). Budaya organisasi mempengaruhi kepuasan kerja karyawan; 4). Disiplin kerja mempengaruhi pengembangan karir; 5). Motivasi mempengaruhi pengembangan karir; 6). Budaya organisasi mempengaruhi pengembangan karir; 7). Kepuasan kerja mempengaruhi pengembangan karir; 8). Disiplin kerja, motivasi kerja, budaya organisasi mempengaruhi kepuasan kerja; 9). Kepuasan kerja memediasi hubungan disiplin kerja, motivasi kerja, dan budaya organisasi terhadap pengembangan karir.
Beyond Mobile Payments: Exploring the Evolution and Future of Fintech (BY IJISRT)
Authors: Ahmad Shah Mushtaq , Harish Khomane , . Shradha , Hansda Kutlu , Chowdhury Diksha , Yadav Sakshi
Published: April 2024

In today's digital age, FinTech’s have become universal, transforming the way individuals conduct financial transactions. However, with the convenience of Fintech also come challenges that users encounter. This book chapter investigates into the changing landscape of Fintech challenges, drawing insights from a comprehensive survey conducted among various respondents The survey finds three primary obstacles faced by users during Fintech: network issues, time consumption, and privacy concerns. Notably, a significant proportion of respondents reported encountering network-related problems, highlighting the critical role of stable connectivity in facilitating seamless transactions. Moreover, the chapter explores into the foiling experienced by users due to the time-and privacy nature of the payment process, shedding light on the need for streamlined and efficient payment mechanisms. Building upon the survey findings, the chapter offers valuable insights into potential strategies and solutions to address these challenges. By elucidating practical approaches and technological innovations aimed at enhancing Fintech systems' efficiency and security, the chapter equips readers with actionable knowledge to navigate the digital payment landscape effectively. This study's findings add to academic discussion and have practical implications for policymakers, industry practitioners, and educators.