bluuebunny/crossref_metadata_2025 huggingface dataset:
Botulinum toxin in the management of chronic migraine: clinical evidence and experience
Authors: Escher Claus M , Paracka Lejla , Dressler Dirk , Kollewe Katja
Published: November 2016

Chronic migraine (CM) is a severely disabling neurological condition characterized by episodes of pulsating unilateral or bilateral headache. The United States Food and Drug Administration (FDA) approved onabotulinumtoxinA (Botox®) for the prophylactic treatment of CM in 2010. It has been shown that onabotulinumtoxinA is effective in the reduction of headache frequency and severity in patients with CM. Treatment is well tolerated by the patients. This review reports on the history of botulinum neurotoxin (BoNT) in CM and presents the current clinical evidence for the use of onabotulinumtoxinA in the treatment of CM.
Future Consciousness
Authors: Lombardo Thomas
Published: November 2016

The central thesis of this article is that the creation of a good future, which is the central challenge of human life, is achieved through wisdom. Wisdom is a holistic capacity that is a synthesis of a set of key character virtues and the highest expression of future consciousness. Future consciousness consists of all normal human abilities and experiences, including emotion, imagination, anticipation, thinking, and purposeful action, involved in our consciousness of the future. The good future involves the facilitation of purposeful evolution, which is maximized through wisdom or heightened future consciousness. The fundamental dynamic principle in the universe is evolution and evolution itself is evolving. Through future consciousness humans have realized an evolution in evolution, involving thoughtful, informed, and purposeful evolution. Future consciousness is the most empowering and distinctive capacity of the human mind, both unique and yet expressive of the natural process of the evolution of evolution. Flourishing in the flow of evolution is a realistic theory of the good future that aligns with our future-directional dynamic reality. Wisdom is the most efficacious means for realizing flourishing and the good future. Wisdom can be strengthened in numerous ways, including the development and execution of a wisdom-inspired ideal future personal narrative. The ongoing development of wisdom provides a preferable direction for humanity’s future evolution. We should embrace an Age of Wisdom as an ideal future grand narrative for humanity. To best facilitate in others the realization of a good future, we should model ourselves on the ideals of wisdom; futurists should be wise people.
Symmetry Lasts Longer Than Random, but Only for Brief Presentations
Authors: Ogden Ruth , Makin Alexis D. J. , Palumbo Letizia , Bertamini Marco
Published: November 2016

Previous research has shown that explicit emotional content or physical image properties (e.g., luminance, size, and numerosity) alter subjective duration. Palumbo recently demonstrated that the presence or absence of abstract reflectional symmetry also influenced subjective duration. Here, we explored this phenomenon further by varying the type of symmetry (reflection or rotation) and the objective duration of stimulus presentation (less or more than 1 second). Experiment 1 used a verbal estimation task in which participants estimated the presentation duration of reflection, rotation symmetry, or random square-field patterns. Longer estimates were given for reflectional symmetry images than rotation or random, but only when the image was presented for less than 1 second. There was no difference between rotation and random. These findings were confirmed by a second experiment using a paired-comparison task. This temporal distortion could be because reflection has positive valence or because it is processed efficiently be the visual system. The mechanism remains to be determined. We are relatively sure, however, that reflectional patterns can increase subjective duration in the absence of explicit semantic content, and in the absence of changes in the size, luminance, or numerosity in the images.
Nodular regenerative hyperplasia rarely leads to liver transplantation: A 20‐year cohort study in all Dutch liver transplant units
Authors: Meijer Berrie , Simsek Melek , Blokzijl Hans , de Man Robert A , Coenraad Minneke J , Dijkstra Gerard , van Nieuwkerk Carin MJ , Mulder Chris JJ , de Boer Nanne KH
Published: November 2016

Background

Nodular regenerative hyperplasia is an uncommon liver condition associated with several autoimmune disorders and drugs. The clinical symptoms of nodular regenerative hyperplasia vary from asymptomatic to severe complications of portal hypertension (nodular regenerative hyperplasia‐syndrome).

Objective

The purpose of this study was to identify the prognosis and optimal management, as well as the role of liver transplantation, in nodular regenerative hyperplasia.

Methods

The pathology databases of all three Dutch liver transplant units were retrospectively scrutinised for explanted livers diagnosed with nodular regenerative hyperplasia or without clear diagnosis. Pre‐ and post‐transplantation clinical, biochemical, radiological and histological information was obtained from electronic and paper records.

Results

In total, 1886 patients received a liver transplant. In 255 patients, nodular regenerative hyperplasia could not be excluded. After detailed chart review, the native livers of 11 patients (0.6%) (82% male, median age: 44 years) displayed nodular regenerative hyperplasia. Seven patients (64%) had underlying disorders or drug exposure which possibly caused nodular regenerative hyperplasia. Laboratory and imaging abnormalities were present in all patients but did not contribute to the diagnosis of nodular regenerative hyperplasia. Five‐year survival was 73% (median follow‐up: four years, range: 2–248 months).

Conclusion

Nodular regenerative hyperplasia is a rare finding in patients, predominantly young males, transplanted for end‐stage liver disease with unknown aetiology. Nonetheless, liver transplantation may have an important role in end‐stage nodular regenerative hyperplasia‐syndrome.
New approaches to divorce with children: A problem of public health
Authors: Vezzetti Vittorio Carlo
Published: November 2016

This broad review elaborates on the most up-to-date knowledge on biochemical and psychobiological aspects of parental loss and other childhood adversities during divorce involving minor children. So far, divorce involving minor children was unfortunately considered by authorities only as a purely juridical problem, and this approach has often allowed a completely different approach according to the Courts. Now, scientific research, also making use of animal models, is demonstrating the biological basis of the problem and the indisputable consequences on the well-being and health of children. The innovative conclusion of this review is that this argument (because of its frequency and gravity) is primarily a question of public health and that it is necessary to further harmonize practices in this area.
Depression and anxiety after 2 years of follow-up in patients diagnosed with diabetes or rheumatoid arthritis
Authors: Gåfvels Catharina , Hägerström Margareta , Rane Kristina , Wajngot Alexandre , Wändell Per E
Published: November 2016

We studied emotional health in patients with diabetes mellitus ( n = 89) or rheumatoid arthritis ( n = 100) aged 18–65 years, at the time of diagnosis and after 24 months. Predictors for depression or anxiety according to the Hospital Anxiety and Depression scale after 2 years were assessed by logistic regression, with psychosocial factors and coping as dependent factors. There were many similarities between patients with diabetes mellitus or rheumatoid arthritis. Having children at home, low score on the Sense of Coherence scale, and high score on the coping strategy “protest” were important risk factors for depression and anxiety after 2 years.
“You Need to Be Sorted Out With a Knife”: The Attempted Online Silencing of Women and People of Muslim Faith Within Academia
Authors: Barlow Charlotte , Awan Imran
Published: November 2016

Academics are increasingly expected to use social media to disseminate their work and knowledge to public audiences. Although this has various advantages, particularly for alternative forms of dissemination, the web can also be an unsafe space for typically oppressed or subordinated groups. This article presents two auto-ethnographic accounts of the abuse and hate academics researching oppressed groups, namely, women and people of Muslim faith, experienced online. In doing so, this article falls into four parts. The first section provides an overview of existing literature, particularly focusing on work which explores the violence and abuse of women and people of Muslim faith online. The second section considers the auto-ethnographic methodological approach adopted in this article. The third section provides the auto-ethnographic accounts of the author’s experiences of hate and abuse online. The final section locates these experiences within broader theoretical concepts, such as silencing, and considers possible implications of such online hate in both an academic context and beyond.
“The image speaks for itself” – or does it? Instant news icons, impromptu publics, and the 2015 European “refugee crisis”
Authors: Mortensen Mette
Published: November 2016

Easy internet access and ubiquitous smart phones have augmented the number of images produced and accelerated the speed by which they are circulated (and likely also forgotten). By contrast to the great quantity of pictures disseminated in today’s connective media, a few photographs gain momentum and are declared to be “icons”. They stand out from the image abundance, grasp the attention of a broad, transnational public, and stir emotional reactions and heated debates. Usually, these iconic images are related to major news events and represent an ongoing conflict or crisis in society in a simple, univocal manner. They quickly turn into standard frames of reference in news and popular culture, seem to require no particular explanation, and are often proclaimed to “speak for themselves”. This article proposes the term “instant news icon” to define and gain a fuller understanding of the role performed by iconic images in today’s connective media, distinguished by convergence between platforms and blurred boundaries between media production and media consumption. First, the article builds a framework based on the concept instant news icon and then applies quantitative and qualitative analyses to study the processes of distribution and meaning-making involved in the emergence of one instant news icon, news photographs from 2015 of a young refugee girl playing with a police officer on a Danish motorway.
Barriers, Motivations, and Preferences for Physical Activity Among Female African American Older Adults
Authors: Gothe Neha P. , Kendall Bradley J.
Published: November 2016

According to the Centers for Disease Control and Prevention, less than 11% of adults more than the age of 65 meet the 2008 Physical Activity Guidelines for Americans. Among minority populations, only 5% of non-Hispanic Black older adults met the guidelines. Given our limited understanding of psychosocial and environmental factors that affect physical activity participation in these groups, the purpose of our focus groups was to investigate barriers, motivators, and preferences of physical activity for community-dwelling African American older adults. Three focus groups were conducted with female African American older adults ( N = 20). Questions posed to each focus group targeted motivations and barriers toward physical activity as well as their preferences for physical activity. The motivations included perceived health benefits of physical activity, social support, and enjoyment associated with engagement in physical activity. Prominent barriers included time and physical limitations, peer pressure and family responsibilities, and weather and poor neighborhood conditions. Group activities involving a dance component and novel exercises such as tai-chi or yoga were preferred choices. These findings should be taken into consideration when designing and implementing research or community physical activity programs for female African American older adults.
Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIA
Authors: Liem Robert I. , Chan Cheeling , Vu Thanh-Huyen T. , Fornage Myriam , Thompson Alexis A. , Liu Kiang , Carnethon Mercedes R.
Published: November 2016

Key Points

SCT status is not significantly associated with longitudinal changes in fitness among African Americans. SCT status is not an independent risk factor for hypertension, diabetes, or metabolic syndrome among African Americans.
Protein ligand-specific binding residue predictions by an ensemble classifier
Authors: Hu Xiuzhen , Wang Kai , Dong Qiwen
Published: November 2016

Background

Prediction of ligand binding sites is important to elucidate protein functions and is helpful for drug design. Although much progress has been made, many challenges still need to be addressed. Prediction methods need to be carefully developed to account for chemical and structural differences between ligands.

Results

In this study, we present ligand-specific methods to predict the binding sites of protein-ligand interactions. First, a sequence-based method is proposed that only extracts features from protein sequence information, including evolutionary conservation scores and predicted structure properties. An improved AdaBoost algorithm is applied to address the serious imbalance problem between the binding and non-binding residues. Then, a combined method is proposed that combines the current template-free method and four other well-established template-based methods. The above two methods predict the ligand binding sites along the sequences using a ligand-specific strategy that contains metal ions, acid radical ions, nucleotides and ferroheme. Testing on a well-established dataset showed that the proposed sequence-based method outperformed the profile-based method by 4–19% in terms of the Matthews correlation coefficient on different ligands. The combined method outperformed each of the individual methods, with an improvement in the average Matthews correlation coefficients of 5.55% over all ligands. The results also show that the ligand-specific methods significantly outperform the general-purpose methods, which confirms the necessity of developing elaborate ligand-specific methods for ligand binding site prediction.

Conclusions

Two efficient ligand-specific binding site predictors are presented. The standalone package is freely available for academic usage at http://dase.ecnu.edu.cn/qwdong/TargetCom/TargetCom_standalone.tar.gz or request upon the corresponding author.
Summit of the Research Coordination Networks for Undergraduate Biology Education
Authors: Eaton Carrie Diaz , Allen Deborah , Anderson Laurel J. , Bowser Gillian , Pauley Mark A. , Williams Kathy S. , Uno Gordon E.
Published: November 2016

The first summit of projects funded by the National Science Foundation’s Research Coordination Networks for Undergraduate Biology Education (RCN-UBE) program was held January 14–16, 2016, in Washington, DC. Sixty-five scientists and science educators from 38 of the 41 Incubator and Full RCN-UBE awards discussed the value and contributions of RCNs to the national biology education reform effort. The summit illustrated the progress of this innovative UBE track, first awarded in 2009. Participants shared experiences regarding network development and growth, identified best practices and challenges faced in network management, and discussed work accomplished. We report here on key aspects of network evaluation, characteristics of successful networks, and how to sustain and broaden participation in networks. Evidence from successful networks indicates that 5 years (the length of a Full RCN-UBE) may be insufficient time to produce a cohesive and effective network. While online communication promotes the activities of a network and disseminates effective practices, face-to-face meetings are critical for establishing ties between network participants. Creation of these National Science Foundation–funded networks may be particularly useful for consortia of faculty working to address problems or exchange novel solutions discovered while introducing active-learning methods and/or course-based research into their curricula.
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response
Authors: Silva Richard C. , Sattlegger Evelyn , Castilho Beatriz A.
Published: November 2016

Genetic and pharmacological interventions in yeast and mammalian cells have suggested a cross-talk between the actin cytoskeleton and protein synthesis. Regulation of the activity of the translation initiation factor 2 (eIF2) is a paramount mechanism for cells to rapidly adjust the rate of protein synthesis and to trigger reprogramming of gene expression in response to internal and external cues. Here, we show that disruption of F-actin in mammalian cells inhibits translation in a GCN2-dependent manner, correlating with increased levels of uncharged tRNA. GCN2 activation increased phosphorylation of its substrate eIF2α and the induction of the integrated stress response master regulator, ATF4. GCN2 activation by latrunculin-B is dependent on GCN1 and inhibited by IMPACT. Our data suggest that GCN2 occurs in two different complexes, GCN2–eEF1A and GCN2–GCN1. Depolymerization of F-actin shifts GCN2 to favor the complex with GCN1, concomitant with GCN1 being released from its binding to IMPACT, which is sequestered by G-actin. These events might further contribute to GCN2 activation. Our findings indicate that GCN2 is an important sensor of the state of the actin cytoskeleton.
MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation
Authors: Cota Rosa Ramírez , Teixidó-Travesa Neus , Ezquerra Artur , Eibes Susana , Lacasa Cristina , Roig Joan , Lüders Jens
Published: November 2016

Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding in the assembly of ordered microtubule arrays. However, the mechanistic basis of this important regulation remains poorly understood. Here, we show that, in human cells, γTuRC integrity, determined by the presence of γ-tubulin complex proteins (GCPs; also known as TUBGCPs) 2–6, is a prerequisite for interaction with the targeting factor NEDD1, impacting on essentially all γ-tubulin-dependent functions. Recognition of γTuRC integrity is mediated by MZT1, which binds not only to the GCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of GCP2, GCP3, GCP5 and GCP6. MZT1 knockdown causes severe cellular defects under conditions that leave γTuRC intact, suggesting that the essential function of MZT1 is not in γTuRC assembly. Instead, MZT1 specifically binds fully assembled γTuRC to enable interaction with NEDD1 for targeting, and with the CM1 domain of CDK5RAP2 for stimulating nucleation activity. Thus, MZT1 is a ‘priming factor’ for γTuRC that allows spatial regulation of nucleation.
The defensive response of the honeybee Apis mellifera
Authors: Nouvian Morgane , Reinhard Judith , Giurfa Martin
Published: November 2016

Honeybees (Apis mellifera) are insects living in colonies with a complex social organization. Their nest contains food stores in the form of honey and pollen, as well as the brood, the queen and the bees themselves. These resources have to be defended against a wide range of predators and parasites, a task that is performed by specialized workers, called guard bees. Guards tune their response to both the nature of the threat and the environmental conditions, in order to achieve an efficient trade-off between defence and loss of foraging workforce. By releasing alarm pheromones, they are able to recruit other bees to help them handle large predators. These chemicals trigger both rapid and longer-term changes in the behaviour of nearby bees, thus priming them for defence. Here, we review our current understanding on how this sequence of events is performed and regulated depending on a variety of factors that are both extrinsic and intrinsic to the colony. We present our current knowledge on the neural bases of honeybee aggression and highlight research avenues for future studies in this area. We present a brief overview of the techniques used to study honeybee aggression, and discuss how these could be used to gain further insights into the mechanisms of this behaviour.
Assessing Fair Lending Risks Using Race/Ethnicity Proxies
Authors: Zhang Yan
Published: November 2016

Fair lending analysis of nonmortgage credit products often involves proxying for race/ethnicity since such information is not required to be reported. Using mortgage data, this paper evaluates a series of proxy approaches (geo, surname, geo-surname, and Bayesian Improved Surname Geocoding (BISG)) as compared with the race/ethnicity reported under the Home Mortgage Disclosure Act (HMDA). The BISG proxy predicts the reported race/ethnicity the best as judged by prediction bias, correlation coefficient, and discriminatory power. In assessing fair lending risks where classification of race/ethnicity is called for, we propose the BISG maximum classification, which produces a more accurate estimation of mortgage pricing disparities than the current practices. The above conclusions withhold various robustness tests. Additional analysis is performed to assess the proxies on nonmortgage credits by leveraging consumer credit bureau data.

This paper was accepted by Amit Seru, finance.
Nursing in Europe: what 1992 has to offer
Authors: Hamer Susan
Published: November 2016

RGNs and midwives have been allowed to work freely throughout Europe since 1977. However, the number of migrating nurses remains comparatively low. It is essential that nurses are culturally aware so that alternative healthcare patterns can be accurately evaluated.
How to plan your career
Authors: Fish Jane
Published: November 2016

Many nurses now feel under enormous pressure to succeed in an increasingly competitive environment. The first step is not to panic but to plan.
Erythema multiforme
Authors: Ashurst Stephen
Published: November 2016

Helen, a 45-year-old farmer's wife with a married daughter, handles sheep every day of her life. She was referred to our consultant dermatologist by her general practitioner with a 3-week history of an orf infection on her left index finger which presented as a white blister with surrounding erythema, together with an herpetic eruption on her face. She had gradually developed a generalized red rash and 3 days previously a bullous eruption was observed which rapidly progressed and was unresponsive to antihistamines given intramuscularly and calamine lotion applied topically.
Advocacy: what the future holds
Authors: Graham Agnes
Published: November 2016

The author offers a personal view of the importance of the advocacy role for nurses and highlights problems that may arise as a result of changes in the National Health Service.
The winds of change: psychiatric nursing in Czechoslovakia
Authors: Telford Anni
Published: November 2016

This article examines the current state of psychiatry and psychiatric nursing within the Czechoslovakian Republic and is the result of the author's invitation to teach on the first Postgraduate Diploma in Cognitive Behavioural Psychotherapy run in Czechoslovakia.
Staff support groups: are they necessary?
Authors: Harvey Peter
Published: November 2016

The NHS has the reputation of being a poor provider of emotional care and support for its staff. However, informal data suggest that staff support work is increasing dramatically and is gaining a higher profile on the management agenda.
Development and cost–benefit analysis of a nurse-led paracentesis and infusion service
Authors: Menon Shyam , Thompson La-Sandra , Tan Maria , Chahal Sundeep , Black Doreen , Hill Keely Anne , Gritton Dean , Hathaway Charlotte , Perry Ian
Published: November 2016

The rising incidence of chronic liver disease has resulted in many patients needing recurrent paracentesis for abdominal ascites, which requires hospital admission. A novel nurse-led and delivered day-case paracentesis and intravenous infusion service was developed, and a cost-benefit analysis was undertaken to examine the impact of this service. Data for patients admitted for ascitic paracentesis and intravenous infusions between April and January 2016 were collected, and procedure-related costs and income were calculated. Savings delivered by the service were calculated by determining the cost of bed-days saved by the day-case service. A qualitative analysis of the efficacy of the service was conducted by a patient feedback survey.

Over the 10-month period, 559 patients were treated by the day-case service—144 ascitic paracenteses (26%), 87 iron infusions (16%), 307 infliximab infusions (55%) and 21 magnesium infusions (3%). Net income over 10-months was £256 876, with an expenditure of £128 570, yielding a profit of £128 306. Cost-modelling exercises indicated that this would yield an additional cost saving of £153 216 due to inpatient bed-days saved, yielding a total financial benefit of £281 522 (over 10-months). A day-case, nurse-led gastroenterology service provides an innovative, profitable and cost-efficient model of service delivery.
Species diversity and utilization of bamboo to support lifeâ€™s the community of Karangwangi Village, Cidaun Sub-District of Cianjur, Indonesia
Authors: HAILU HAILU WELDEKIROS , SAJIDAN SAJIDAN , PANGASTUTI ARTINI , GREINER RALF
Published: November 2016

Abstract. Hailu HW, Sajidan, Pangastuti A, GreinerR. 2017. Isolation, characterization and 18S rDNA sequence analysis of phytase producing fungi from Indonesia, Indonesia. Biodiversitas 18: 10-14. Phytase breaks down the phytate portion of grains and oil seeds; thereby, releasing phosphorus and minerals for animals. The objectives of this research were to screen phytase-producing novel species of fungi; to conduct cultural and phylogenetic characterization; to perform 18S rDNA sequencing and BLAST analysis. Samples of fungi were collected from different sources, cultured on potato dextrose agar and potato dextrose broth. Phytase assay was conducted based on Vanadate-molybdate method. Three isolates with highest enzyme activity were selected for pH and temperature optimization. DNA was extracted by modifying plant DNA extraction and yeast genomic DNA extraction kits. The 18S rDNA gene was amplified and sequenced. The result indicated that optimum temperatures ranged from 60-75oC and the optimum pH for isolates from papaya (Angr), palm bark (Abark) and sugarcane soil field (Asoil) were 4.5, 3.0 and 4.5, respectively. Based on 18S rDNA sequence analysis the phytase producing fungal isolates Angr, Abark and Asoil were identical to Aspergillus niger, Beauveria felina and Nigrosabulum globosum, respectively.Keywords: 18S rDNA, BLAST, fungi, phytase, phylogeny
Inventory and conservation plant of oke sou traditional ceremony; a welcoming tradition of maturity girl on the community of Lako Akediri Village, West Halmahera, Indonesia
Authors: WAKHIDAH ANISATU Z. , SILALAHI MARINA , PRADANA DIMAS H.
Published: November 2016

Abstract. Wakhidah AZ, Silalahi M, Pradana DH. 2017. Inventory and conservation plant of oke sou traditional ceremony; A welcoming tradition of maturity girl on the community of Lako Akediri Village, West Halmahera, Indonesia. Biodiversitas 18: 65-72. Welcoming ceremony maturity girl (oke sou) is a hereditary tradition from Lako Akediri Village which believed effective in maintaining health and beauty of girl. Oke sou ceremony held when the girl gets her first menstruation. This preliminary research aims to document plant species used in oke sou ceremonies and to explain conservation behavior of community at Lako Akediri Village towards the used plant. The investigation was conducted twice, first on May-June 2014 resumed on October 2014. Ethnobotanical data were collected using semi-structured interviews method to a village shaman, traditional elders, and local women (30 respondents). Plant specimens collected from its habitat, made herbarium, and then identified. Recorded as many as 88 plant species from 78 genera belonging to 46 families used by community at Lako Akediri Village in oke sou ceremony. Rice (Oryza sativa L.) is the most mentioned plant by the local community (20 respondents). The most widely used families are Fabaceae and Lamiaceae, each family has 7 species. The highest source of plant in oke sou ceremony derived from cultivated which in total 37 species (42%). This number represents used plants in oke sou ceremony have been widely cultivated by Lako Akediri community. The results of this study will enrich database of local knowledge in Indonesia and become source of research object in developing natural ingredients for human welfare.
Antimicrobial potential of Carica papaya, Ipomoea aquatica, Alpinia galanga and Piper betle against the aquatic microbials
Authors: SAPTIANI GINA , HARDI ESTI HANDAYANI , PEBRIANTO CATUR AGUS , AGUSTINA AGUSTINA , ARDHANI FIKRI
Published: November 2016

Abstract. Saptiani G, Hardi EH, Pebrianto CA, Agustina, Ardhani F. 2016. Antimicrobial potential of Carica papaya, Ipomoea aquatica, Alpinia galanga and Piper betle against the aquatic microbials. Nusantara Bioscience 8: 252-257. This research was aimed to investigate the antimicrobial potential of the leaves extract from Carica papaya, Ipomoea aquatica, Piper betle and Alpinia galanga stem against Aeromonas hydrophila, Pseudomonas sp., Escherichia coli, and Saprolegnia spp.; the pathogenic microbes in aquatics. These plants were dried and extracted with water and ethanol, separately. The extract was then tested for its inhibition effect to the microbial by in vitro agar disc diffusion (ADD) at the concentration of 100, 200, 400, 600, 800, and 1,000 ppm and minimal inhibitory concentration (MIC) at the concentration of 600, 800, and 1,000 ppm. The result showed that water or ethanol extract f of plants showed potent inhibitor against the aquatic microbial. The ethanol extract of P. betle showed the highest inhibition at 800 ppm, with inhibition zones to A. hydrophila, and Pseudomonas sp. 12.3 mm, E. coli, and Saprolegnia spp. 12.7 mm. One thousand ppm ethanol extract of P. betle could inhibit the best microbes growth using MIC method to A. hydrophila 189.7 cfu/mL, Pseudomonas sp. 253.0 cfu/mL, Saprolegnia spp.169.3 cfu/mL, and 800 ppm to E. coli 172.7 cfu/mL.
Title: Development and Refinement of a Learning Health Systems Training
Program
Authors: Wysham Nicholas G. , Howie Lynn , Patel Krish , Cameron C. Blake , Samsa Gregory P. , Roe Laura , Abernethy Amy P. , Zaas Aimee
Published: November 2016

Context: In the emerging Learning Health System (LHS), the application and
generation of medical knowledge are a natural outgrowth of patient care. Achieving this
ideal requires a physician workforce adept in information systems, quality improvement
methods, and systems-based practice to be able to use existing data to inform future
care. These skills are not currently taught in medical school or graduate medical
education.Case Description: We initiated a first-ever Learning Health Systems Training
Program (LHSTP) for resident physicians. The curriculum builds analytical, informatics
and systems engineering skills through an active-learning project utilizing health
system data that culminates in a final presentation to health system
leadership.Findings: LHSTP has been in place for two years, with 14 participants from
multiple medical disciplines. Challenges included scheduling, mentoring, data
standardization, and iterative optimization of the curriculum for real-time instruction.
Satisfaction surveys and feedback were solicited mid-year in year 2. Most respondents
were satisfied with the program, and several participants wished to continue in the
program in various capacities after their official completion.Major themes: We adapted
our curriculum to successes and challenges encountered in the first two years.
Modifications include a revised approach to teaching statistics, smaller cohorts, and
more intensive mentorship. We continue to explore ways for our graduates to remain
involved in the LHSTP and to disseminate this program to other
institutions.Conclusion: The LHSTP is a novel curriculum that trains physicians to lead
towards the LHS. Successful methods have included diverse multidisciplinary educators,
just in time instruction, tailored content, and mentored projects with local health
system impact.
Procurement costs of cereal straw and forest chips for biorefining in South-East Finland
Authors: Laitila Juha , Lehtonen Eeva , Ranta Tapio , Anttila Perttu , Rasi Saija , Asikainen Antti
Published: November 2016

In Finland the increasing use of biofuel in transport presupposes a search for new raw material sources for biorefining. The aim of this study was, at the regional level, to compare the procurement costs of logging residues, stumps, delimbed stems and cereal straw for biorefining. The accumulation and procurement costs of forest chips and cereal straw were estimated within a 100-kilometre transporting distance via existing road network from an end-use-facility located in Kouvola in South-East Finland. The analyses were performed as simulated treatments in thinnings of young stands, cereal fields and regeneration fellings using existing productivity and cost functions and yield calculations based on crop statistics, the forest industry stand data and the sample plots data of the National Forest Inventory of Finland. Accumulation of raw material assortments and costs of production stages were defined per dry tonnes. Subsidies and raw material prices were excluded from consideration in the study. The results indicate that recovering logging residues requires lower costs than utilization of stumps, delimbed stems or cereal straw. Cereal straw represents an important source of biomass in Kouvola but the cost competiveness is poor compared the procurement costs of forest chips. When the annual procurement volume of biomass was 50â000 dry tonnes the cost at the plant was 49 â¬ dry tonne and biomass was comprised totally of logging residues. Procurement cost grew to 59 â¬ dry tonne when the annual procurement volume of biomass was doubled to 100â000 dry tonnes. Of that amount, the proportion of logging residues was 58.4%, stumps 24.3% and delimbed stems 17.3%. First cereal straw dry tonnes were delivered to end-use-facility, when procurement cost grew to 60 â¬ dry tonne and annual procurement volume of biomass was 110â000 dry tonnes.â1â1â1
Implantação e uso de um sistema de monitoramento automatizado para avaliação da produção de poços em região de ocorrência do sistema aquífero serra geral
Authors: De Oliveira Dutra Tuane , Roehe Reginato Pedro Antonio , Imério Leão Marcos , Barbosa Athayde Gustavo , Alves Paim Rosana
Published: November 2016

O presente estudo foi realizado no município de Carlos Barbosa, localizado na região nordeste do estado do RS, que é abastecido exclusivamente por águas subterrâneas do Sistema Aquífero Serra Geral (SASG). Neste município foi instalado um sistema de monitoramento automatizado, denominado de SIGAS, em 12 dos 15 poços tubulares que captam água do SASG e são utilizados pela CORSAN para o abastecimento público de água no munícipio. O SIGAS monitora volume, vazão e tempo de bombeamento de 15 em 15 minutos e nível de água de 1 em 1 minuto. Foram analisados os dados coletados em 3 poços dos 12 que possuem o sistema. Os dados coletados indicaram que os 3 poços estão trabalhando, na maior parte do período monitorado, acima do tempo de bombeamento projetado, com tempos sem bombeamento operados de forma descontínua. O SIGAS se demostrou um sistema satisfatório para o monitoramento de poços tubulares, inseridos no Sistema Aquífero Serra Geral e utilizados para o abastecimento público, possibilitando a identificação da influência da demanda na operação dos mesmos e o reflexo desta operação nos níveis de água do aquífero no poço. Devido à frequência de coleta de dados e o fácil acesso aos mesmos pelo órgão gestor dos poços, o SIGAS se demostrou ser uma ferramenta de utilidade impar na gestão dos poços.
On a nonlocal elliptic system with transmission conditions
Authors: Ayoujil Abdesslem , Ourraoui Anass
Published: November 2016

In this paper, we study a transmission problem given by a system of two nonlinear equations of
Climate Change in Hungarian Rural Society: Assessment of Adaptive Capacity
Authors: Vancsó Judit Pappné , Hoschek Mónika , Jankó Ferenc
Published: November 2016

Beside sustainable development, vulnerability might be the most frequently used expression in environmental studies. Vulnerability depends on the intensity of the impacts on a natural or social system as well as on its adaptive capacity. Appropriate adaptation warrants successful survival of the system even under high impact, when its vulnerability is significantly reduced; therefore, measuring adaptive capacity should have an established place in the methodology of impact – adaptation – vulnerability research. The main problem is to find relevant data that are required to establish indicators. In our study, the focus was laid on measuring adaptive capacity within vulnerability research, and on identifying possibilities for accurate calculation of adaptation. An attempt was made to determine the adaptive capacity to droughts in the micro-regions of Zala County. It could be established that the adaptive capacity of the population in the rural areas of Zala County to the expected increase in drought frequency is very low, which can be primarily explained by the lack of knowledge about adaptive agriculture.
On local rigidity of partially hyperbolic affine ℤ
k
actions
Authors: Damjanović Danijela , Fayad Bassam
Published: November 2016

The following dichotomy for affine

ℤ
k

\mathbb{Z}^{k}

actions on the torus

𝕋
d

{\mathbb{T}}^{d}

,

k
,
d

∈
ℕ

k,d\in{\mathbb{N}}

, is shown to hold: (i) The linear part of the action has no rank-one factors, and then the affine action is locally rigid. (ii) The linear part of the action has a rank-one factor, and then the affine action is locally rigid in a probabilistic sense if and only if the rank-one factors are trivial. Local rigidity in a probabilistic sense means that rigidity holds for a set of full measure of translation vectors in the rank-one factors.
Environmental Factors’ Consideration at Industrial
Transportation Organization in the «Seaport – Dry
port» System
Authors: Muravev Dmitri , Rakhmangulov Aleksandr
Published: November 2016

Currently, container shipping development is directly
associated with an increase of warehouse areas for
containers’ storage. One of the most successful types of
container terminal is an intermodal terminal called a dry
port. Main pollution sources during the organization of intermodal
transport are considered. A system of dry port
parameters, which are recommended for the evaluation
of different scenarios for a seaport infrastructure development
at the stage of its strategic planning, is proposed in
this paper. The authors have developed a method for determining
the optimal values of the main dry port parameters
by simulation modeling in the programming software Any-
Logic. Dependencies thatwere obtained as a result of modeling
experiments prove the adequacy of main selected dry
port parameters for the effective scenarios’ evaluation of
throughput and handling capacity at existing seaports at
the stage of strategic planning and a rational dry port location,
allowed ensuring the improvement of the ecological
situation in a port city.
Entropy as a measure of mixedupness of realizations in child speech
Authors: Babatsouli Elena , Ingram David , Sotiropoulos Dimitrios A.
Published: November 2016

Typical morpho-phonological measures of children’s speech realizations used in the literature depend linearly on their components. Examples are the proportion of consonants correct, the mean length of utterance and the phonological mean length of utterance. Because of their linear dependence on their components, these measures change in proportion to their component changes between speech realizations. However, there are instances in which variable speech realizations need to be differentiated better. Therefore, a measure which is more sensitive to its components than linear measures is needed. Here, entropy is proposed as such a measure. The sensitivity of entropy is compared analytically to that of linear measures, deriving ranges in component values inside which entropy is guaranteed to be more sensitive than the linear measures. The analysis is complemented by computing the entropy in two children’s English speech for different categories of word complexity and comparing its sensitivity to that of linear measures. One of the children is a bilingual typically developing child at age 3;0 and the other child is a monolingual child with speech sound disorders at age 5;11. The analysis and applications demonstrate the usefulness of the measure for evaluating speech realizations and its relative advantages over linear measures.
About the Benefits of Pleasure-in-Others’-Misfortune. Aaron Ben-Ze’ev’s Depiction of Emotions as Adaptive Mechanisms
Authors: Michalik-Jeżowska Magdalena
Published: November 2016

This paper was inspired by two ideas: (1) the concept of emotions as adaptive mechanisms, which was suggested by Aaron Ben-Ze’ev, and (2) Robert Solomon’s criticism of the distinction between “positive” and “negative” emotions which functions in social sciences. In the context of the above mentioned theoretical perspectives I consider the infamous emotion of pleasure-in-others’-misfortune in terms of possible benefits for the experiencing subject. I focus especially on supposed adaptive quality of pleasure-in-others’-aging.
Preface: Research Approaches to the Study of Religion
Authors: Oviedo Lluis
Published: November 2016

First of all we pay attention to cognitive studies of religion and compare theology and philosophy of religion.
Searching for Neurobiological Foundations of Faith and Religion
Authors: Weker Maria
Published: November 2016

Considering that the brain is involved in human thinking, feeling and behaviour, we must also ask the question of whether finding neural correlates of religious experience is not just a matter of time. The questions ‘if’ and ‘how’ human brain responds to or generates religious experience capture the interest of researchers from various fields of science. Their joint efforts and scientific discourse lead to implementation of bold interdisciplinary research projects, with a far-reaching goal of explaining the mystery of faith and religion. Studies conducted at the meeting point of empirical and theological sciences raise controversies and criticism. Examples include the discussions on natural and theological experiments, collectively called neurotheology.
Hyperinsulinemic hypoglycemia associated with insulin antibodies caused by exogenous insulin analog
Authors: Su Chih-Ting , Lin Yi-Chun
Published: November 2016

Insulin antibodies (IA) associated with exogenous insulin administration seldom caused hypoglycemia and had different characteristics from insulin autoantibodies (IAA) found in insulin autoimmune syndrome (IAS), which was first described by Dr Hirata in 1970. The characteristic of IAS is the presence of insulin-binding autoantibodies and related fasting or late postprandial hypoglycemia. Here, we report a patient with type 1 diabetes mellitus under insulin glargine and insulin aspart treatment who developed recurrent spontaneous post-absorptive hyperinsulinemic hypoglycemia with the cause probably being insulin antibodies induced by exogenous injected insulin. Examinations of serial sera disclosed a high titre of insulin antibodies (33%, normal <5%), high insulin concentration (111.9 IU/mL) and undetectable C-peptide when hypoglycemia occurred. An oral glucose tolerance test revealed persistent high serum levels of total insulin and undetectable C-peptide. Image studies of the pancreas were unremarkable, which excluded the diagnosis of insulinoma. The patient does not take any of the medications containing sulfhydryl compounds, which had been reported to cause IAS. After administering oral prednisolone for 3 weeks, hypoglycemic episodes markedly improved, and he was discharged smoothly.

Learning points:

Insulin autoimmune syndrome (IAS) or IAS-like situation should be one of the differential diagnosis in patients with hyperinsulinemic hypoglycemia.

Although less reported, insulin antibodies (IA) caused by exogenous insulin analog should be considered as the cause of hypoglycemia.

Patients with suspected insulin autoimmune syndrome (IAS) should be screened for drugs related to autoimmunity to endogenous insulin.
El ambiente: Tema o eje en el programa museológico
Authors: Madrigal-Mora Álvaro
Published: November 2016

Recibido: 09/ 22/2014 Aceptado: 06/28/2016La Cumbre de Museos de América, “Museos y Comunidades Sostenibles”, de 1998 donde Costa Rica asiste, los participantes asumieron el compromiso de velar por que sus instituciones sean constructoras de herramientas para la sostenibilidad de sus comunidades. Trece años más tarde, el Programa de Patrimonio, Desarrollo y Sociedad, de la Escuela de Sociología, llevó a cabo una investigación con el fin de indagar los avances de tres museos de Costa Rica (Museo Nacional, Museo de Arte Costarricense y Museo del Banco Central) para cumplir con este compromiso, basándose en 4 ejes: medio ambiente, género, accesibilidad y grupos marginales. En este artículo exploramos, cómo estos museos han incorporado el eje del medio ambiente en su trabajo, tratando de determinar qué acciones se han desarrollado en esta área y en qué medida. Los tres museos han llevado a cabo diferentes actividades en este eje, como: exposiciones, mejores prácticas ambientales, etc., Sin embargo, ninguna de ellas, son en respuesta a unas políticas institucionales, que permiten un trabajo sistemático, por lo que es necesario, que los museos desarrollen no sólo acciones o actividades sino políticas que permiten un trabajo más sistemático en este eje.
Estrategias de comunicación de los museos nacionales
Authors: Salazar-Miranda Adriana
Published: November 2016

Recibido: 09/ 22/2014 Aceptado: 06/27/2016El objetivo es estudiar las estrategias de comunicación que emplea el Museo Nacional de Costa Rica, los Museos del Banco Central y el Museo de Arte Costarricense, ubicados en la zona central de la provincia de San José en Costa Rica, con el fin de conocer las estrategias que utilizan para brindar acceso y dar información a diversos grupos poblacionales sobre la oferta museística que ofrecen. El problema de estudio es que uno de los retos que enfrentan los museos es asegurar la visitación permanente y dinámica, a fin de preservar y asegurar su sostenibilidad y razón de ser, ante lo cual la comunicación se convierte en un puente entre los museos y los públicos. Los resultados más interesantes: los tres museos han implementado diversas acciones de comunicación, similares en estrategia; sin embargo, enfrentan una serie de retos en cuanto al monitoreo y la evaluación del impacto de lo realizado, escaso personal en los departamentos de comunicación, limitados recursos económicos y escaso conocimiento de los perfiles de los públicos visitantes.