bluuebunny/crossref_metadata_2025 huggingface dataset:
MAPPING RESEARCH DEVELOPMENTS AND TRENDS: SUSTAINABLE ECONOMIC LITERACY IN ISLAMIC CONTEXT
Authors: Mukti Titania
Published: February 2025

This study presents a bibliometric analysis of islamic sustainable economic research from scopus indexed scientific publications. Data sources were obtained from searches using the publish or perish application with the keywords “islamic AND sustainable AND economy” total of 205 articles from 2007-2024. Statistical analysis of metadata using the VOS Viewer application. This study analyzes the trend of research development based on the year of publication, journal contribution, journal citation, country, co-authorship, authors, keywords used, and visualization analysis of the research landscape cluster. The results show that the keywords "sustainable development", "islamic finance", and "waqf" can be said to be developing quite well because each year shows an increase in the number of studies relevant to these keywords. The author who produces the most article is M. Kabir Hassan with 7 articles. The most articles were produced in 2022 with total 28 articles. Malaysia is the most contributing country to publish 64 articles. Research clusters consisting of 10 clusters. The direction of future research development that still rarely researched in the role of Islamic microfinance for sustainable economic development, Islamic financial performance to realize a sustainable economy, politics and regulation for an Islamic-based sustainable economy
MEDIA EFFECTIVENESS OF ANDROID-BASED E-GEA APPLICATION TO IMPROVE CRITICAL THINKING SKILLS
Authors: Dewi Clara Adhi Pratiwi Sukmana , Muryani Chatarina , Sarwono Sarwono , Noviani Rita
Published: February 2025

This study aims to test the effectiveness of Android-based E-GeA learning media in improving the critical thinking skills of grade X students of SMA Negeri Kebakkramat, Karanganyar. The E-GeA application for Electronic Geography Adventure is designed to support geography learning through interactive features, such as learning videos, materials, animations, and pre-test and posttest-based exams. The study used an experimental and purposive sampling technique on 36 students in grades X-5. The data were analyzed using normality, n-gain, and t-test tests. The results showed that the t-test results showed a significant difference between the pre-test 30 and post-test 86 scores, with 94% of students achieving KKM scores. This study proves that E-GeA learning media improves students' critical thinking skills. These findings provide recommendations for integrating technology in geography learning to support improving the quality of education and skills in the 21st century.
Legumes in portuguese kindergartens: an analysis of frequency and acceptance level
Authors:   CBQF - Centro de Biotecnologia e Química Fina – Laboratório Associado, Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Rua Diogo Botelho, n.º 1327, 4169-005 Porto, Portugal, Vieira Evla Darc Ferro , Gomes Ana Maria ,   CBQF - Centro de Biotecnologia e Química Fina – Laboratório Associado, Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Rua Diogo Botelho, n.º 1327, 4169-005 Porto, Portugal, Gil Ana M ,   Department of Chemistry and CICECO- Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal, Vasconcelos Marta ,   CBQF - Centro de Biotecnologia e Química Fina – Laboratório Associado, Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Rua Diogo Botelho, n.º 1327, 4169-005 Porto, Portugal
Published: February 2025

Legumes are environmentally sustainable, nutritious, and culturally significant foods in the Mediterranean region. However, Portuguese children consume only 6% of the daily recommendations. Kindergartens play a crucial role in shaping children's eating habits, making it essential to promote the consumption of these foods in these settings. This study aimed to identify legume consumption and its associated factors in nine Portuguese kindergartens, according to teachers’ perceptions. It is preliminary participatory research, employing both qualitative and quantitative approaches, using a structured questionnaire and an online focus group. Questionnaire data were presented in absolute numbers and frequencies, using Fisher's exact test. Data from the focus group were analyzed and interpreted using thematic content analysis. Quantitatively, it was observed that 77.8% of schools provide vegetarian meals approximately once a week. Legume grains are offered on average 3 times a week in 55.6% of schools. The acceptance level of legumes is 55.6%. The content analysis found that knowing how to cook legumes and family involvement in food education were positive aspects. The identified barriers were meal preparation outside of school and a lack of habit of consuming legumes. Based on these results, it is recommended that actions aimed at developing culinary skills in preparing legumes, food education with parental involvement, food
preparation within the school, and the introduction of legumes in menus be prioritized in selected schools as early as possible.
Intervenção alimentar e nutricional na prevenção de deficiências intelectuais e cognitivas em crianças com fenilcetonúria
Authors:   Escola Superior de Saúde do Instituto Politécnico de Leiria, Campus 2 – Morro do Lena – Alto do Vieiro, Apartado 4137, 2411-901 Leiria, Portugal, Figueiredo Ana , Jorge Rui ,   Escola Superior de Saúde do Instituto Politécnico de Leiria, Campus 2 – Morro do Lena – Alto do Vieiro, Apartado 4137, 2411-901 Leiria, Portugal,   ciTechCare - Center for Innovative Care and Health Technology, Hub de Inovação de Saúde, Politécnico de Leiria Campus 5, Rua das Olhalvas, 2414-016 Leiria, Portugal
Published: February 2025

A fenilcetonúria é uma doença que resulta de um erro congénito autossómico recessivo do metabolismo da fenilalanina. Este distúrbio provoca elevações nas concentrações plasmáticas deste aminoácido acarretando graves problemas ao nível do sistema nervoso. De acordo com a evidência encontrada, a introdução do recém-nascido em programas de rastreio neonatais específicos, parece melhorar e proporcionar nestas crianças uma vida relativamente normal. A necessidade de melhores opções de tratamento levou ao desenvolvimento de novas estratégias terapêuticas capazes de promover uma melhor qualidade de vida aos portadores desta doença. Este artigo de revisão demonstra como a implementação nutricional e alimentar precoce é um fator determinante na gestão desta patologia, onde o intuito é avaliar a influência que a alimentação tem no desenvolvimento cognitivo em crianças com fenilcetonúria.
Resolution of Nusyuz Conflict on Household in Hadith Ahkam Perspective
Authors: Jannah Miftahul , Husti Ilyas , - Rahma
Published: February 2025

Marriage aims to create a peaceful and serene household. In domestic life, there are rights and obligations between husband and wife that must be mutually fulfilled so that the goals of marriage can be achieved. However, if one party violates their rights and obligations, that is called nusyuz. Nusyuz is essentially divided into two, nusyuz husband and nusyuz wife. The method used in this research is a qualitative method based on library research. Data collection techniques use references from various books, journals and articles. Meanwhile, the data analysis technique in this research uses data presentation and drawing conclusions. The results of the research explain that the solution to a nusyuz conflict is if the wife commits nusyuz, then the husband's actions take several stages, namely advising the wife, separating the bed, and hitting the wife with a blow that does not hurt. If it is the husband who carries out the nusyuz, then the action taken by the wife is to advise the husband, ask for ishlah (peace), and the final step is to make a complaint to the judge.
Does Resident Gender or Race/Ethnicity Affect Orthopaedic Surgery Case Volume During Residency Training?
Authors: Shoga Parisun , Van Heest Ann , Ames S. Elizabeth , Hogan Sean O. , Holmboe Eric , Klingensmith Mary , Park Yoon Soo , Parker Corey , Solberg Erik , Templeton Kimberly
Published: February 2025

Introduction:

Disparities in case volumes have been reported in some surgical specialties. The objective of this study was to evaluate whether gender or racial/ethnicity disparities exist during orthopaedic surgery residency surgical case log volume.

Methods:

Accreditation Council for Graduate Medical Education Case Log Database for orthopaedic surgery residents for 9 years of cohorts graduating in academic years 2013-2014 to 2021-2022 were analyzed to compare case logs between men and women, as well as race/ethnicity, defined by Association of American Medical Colleges as underrepresented in medicine (URiM) and non-URiM groups.

Results:

Longitudinal analyses of total required minimum type cases indicate significant gender differences among the initial graduating cohorts with women trainees reporting 33 cases fewer than men; in the most recent years of this study period, women trainees reported 5 cases fewer than men per year. URiM trainees reported 29 cases fewer at baseline, while in the most recent years, there were no significant differences. Significant differences exist for 8 of the 15 case minimum types with fewer women cases at baseline; in the most recent years, women had fewer cases in anterior cruciate ligament Reconstruction, Ankle Fracture Fixation, Closed Reduction Forearm Fracture, Total Hip Arthroplasty, and Total Knee Arthroplasty. There were significant differences for 3 of 15 case minimum types at baseline for URiM trainees with no significant differences in most recent years. Hand was the only anatomic area with women reporting significantly more cases than men, both initially and over the 9 years of study period.

Conclusion:

Significant differences exist in case volume and case types during orthopaedic surgery residency based on gender for the initial cohort, albeit lessening in most recent years. Although initial differences in cases volumes based on race/ethnicity exist, no significant differences persist in most recent years of the study period.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
Notes on Bedload Sediment Collector Deployment: Eau Claire River, Wisconsin
Authors: Theiling Charles
Published: February 2025

A bedload sediment collector field deployment was conducted during low flow conditions from August 2023 to September 2023 on the Eau Claire River, Wisconsin, to assess the operation and performance of a 12 ft bedload sediment collector (BSC).* This initial deployment of the technology served to familiarize the research team with the new 12 ft BSC system in preparation for its potential deployment during high flow conditions and at other locations. The insights from this study are intended to identify opportunities to use this technology, particularly in the Upper Mississippi River navigation system.
[PÓSTER] New fluorescent Schiff base modified nanocellulose-based chemosensors for the selective detection of Fe3+, Zn2+ and Cu2+ in semi-aqueous media and application in seawater sample
Authors: EL HASKOURI BENNAGI JAMAL , Ben Haj Fraj Sarah , Amorós del Toro Pedro , Ros-Lis José Vicente , Neri Giovanni , V Baouab Mohamed Hassen , Ferlazzo Angelo
Published: February 2025

Cellulose is the most abundant linear carbohydrate bio-polymer in nature. It’s well-known as the most renewable, biocompatible, biodegradable, cost-effective and eco-friendly. In recent years, the shift from MCC to nanocellulose NC has rapidly attracted a great attention and has gained much interest as a new class of nanoscale biopolymers and as the new renewable source from both academia and industry researchers due to its promising potential in applications. NC is specifically characterized by a great dispersibility, high aspect ratio, large surface area, high mechanical strength, high crystallinity and thermal expansion coefficient. Thus, Schiff bases with an azomethine or imine (-C=N-) group have been extensively designed and used in field of cation species sensing, anions, proteins and organic substances, because of their simple preparation, high yield and easy structural modifications that can coordinate different analytes via the pair of electrons of azomethine nitrogen (-C=N) that make various complexes. Fluorometric chemosensors/probes are very effective for the detection and quantification of heavy metal ions, being the recognition simple process, that leads to high sensitivity, distinguished selectivity and excellent efficiency at low-cost. However, these small molecules are sometimes unstable in the surrounding changes in solutions. So, a new alternative has recently proposed using Schiff base-modified cellulose. For example, WANG et al. (2023) [1] developed a fluorescent coumarin derivative grafted dialdehyde cellulose-based probe for the detection of Fe3+. In this study, four new fluorescent dyes, namely, S1: (PDA-DANC), S2: (SAL-PDA-DANC), S3: (BrSAL-PDA-DANC) and S4: (ClSAL-PDA-DANC) have been successfully synthesized from (DANC) for the detection of heavy metal. The microstructural and photophysical properties of (NC), (DANC) and the synthesized dyes were investigated by FT-IR, SEM-EDX, XRD, TGA, DLS and photoluminescence.
Modification and Performance Evaluation of Radio Frequency Identification Technology in High-Temperature and High-Pressure Environments
Authors: Zhang Jian , Yu Peihang , Zhou Zhaoming , Li Hui , Zhou Ting , Yu Chunlei
Published: February 2025

As oil and gas exploration progresses into deeper and ultradeep territories, the radio frequency identification (RFID) tags used in drillpipes are required to demonstrate enhanced resilience to elevated temperatures and pressures. Current research on tags for ultrahigh temperature and ultrahigh pressure environments is relatively scarce. This study focuses on the application of RFID in deeper drilling operations, aiming to further enhance the tags’ temperature and pressure resistance to meet the application requirements. Numerical simulations were conducted to assess the mechanical properties of RFID tags installed on drillpipes of varying dimensions under conditions of elevated temperatures and pressures. This process enabled the optimization of the dimensions of the RFID tags and installation holes. The optimal dimensions for the RFID tag were determined to be φ24.3×7 mm, with the corresponding installation hole being φ24.3×11 mm. To evaluate the high-temperature endurance of the RFID tags, they were subjected to a temperature of 200℃ for a period of time, after which a maximum temperature of 230℃ was applied. Furthermore, a bespoke high-temperature and high-pressure apparatus was used to conduct a 7-day endurance test at 200℃ and 200 MPa. The findings demonstrated that the RFID tags exhibited reliable performance even when subjected to an extreme temperature of 230℃. Furthermore, the RFID tags exhibited consistent performance when subjected to prolonged periods of high temperature and pressure. The efficacy of the RFID tags was further validated through an 11-well field experiment, wherein the embedded tags exhibited no indications of detachment or deterioration. Once removed from the apparatus, the tags were able to be read automatically in real time, thus enabling the automated collection of data from the drillpipe in actual operating conditions. The findings of this study provide valuable insights and establish a foundation for the design and application of RFID tags in the challenging environments of deep and ultradeep oil and gas exploration.
WITHDRAWN: Wavelength selection algorithm for near-infrared spectra of volatile organic gases based on wave-cluster interval
Authors: Yue Yan
Published: February 2025

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Effects of biofertilizers and nano iron-silicon oxide on yield, dry matter remobilization, and trend of changes of the grain filling of triticale under salinity stress
Authors: Aghaei Fatemeh , SeyedSharifi Raouf , Farzaneh Salim , Narimani Hamed
Published: February 2025

Salinity is the major abiotic stress factor negatively affecting numerous crop plants’ morphological and biochemical traits, resulting in reduced agricultural production and sustainability. Iron-silicon (Fe-Si) nanoparticles (NPs) and plant growth-promoting rhizobacteria can decrease abiotic stress and improve crop yield. Accordingly, a factorial experiment was conducted in 2021 under greenhouse conditions using a randomized complete block design with three replicates. The treatment included salinity at three levels (no salinity, 35 mM and 70 mM with sodium chloride), four levels of NP foliar application (foliar application with water as control, nano Si, nano Fe, and Fe-Si NPs), and four levels of plant growth-promoting rhizobacteria (PGPR; no application, Pseudomonas, Azospirillum, and Azospirillum and Pseudomonas applications). According to the results, the highest dry matter remobilization from shoot and stem and the contribution of stem reserves to the grain yield were found in severe salinity stress conditions. In addition, under 70 mM salinity stress conditions, PGPR and nano Fe-SiO applications increased carotenoid content (51.1%), leaf area index (39.4%), total Chl (31.4%), chlorophyll a (29.1%), grain-filling duration (22.2%), effective grain-filling duration (EGFD, 16.3%), and grain yield (12.8%) when compared to control (no PGPR and NP applications) at the same level of salinity. According to the findings, the application of PGPR and NPs increased the grain yield of triticale in salinity stress conditions because of improving the components of grain filling and some physiological features.
Soil bacterial diversity and community structure of cotton rhizosphere under mulched drip- irrigation in arid and semi-arid regions of Northwest China
Authors: Zhang Man , Hu Yang , Ma Yue , Hou Tianyu , Wang Juanhong , Che Qingxuan , Chen Bolang , Wang Qinghui , Feng Gu
Published: February 2025

Background
Xinjiang is situated in an arid and semi-arid region, where abundant heat and sunlight create highly favorable conditions for cotton cultivation. Xinjiang's cotton output accounts for nearly one-quarter of global production. Moreover, the implementation of advanced planting techniques, such as 'dwarfing, high-density, early-maturing' strategies combined with mulched drip irrigation, ensures stable and high yields in this region. Despite these advancements, limited research has focused on the microbial mechanisms in cotton fields employing these advanced planting methods.
Results
The bacterial and phoD communities in the cotton rhizosphere were predominantly composed of nine bacterial phyla (i.e., Proteobacteria, Actinobacteria, Acidobacteria, Gemmatimonadetes, Chloroflexi, Bacteroidetes, Rokubacteria, Firmicutes, and Nitrospirae) and five phoD phyla (i.e., Proteobacteria, Actinobacteria, Planctomycetes, Acidobacteria, and Firmicutes), respectively. Alpha diversity analysis indicated that the medium yield cotton field (MYF) exhibited higher bacterial richness and diversity indices compared to low yield (LYF) and high yield (HYF) fields. The symbiotic network analysis of LYF revealed greater values of average degree, number of edges, and modularity, suggesting a more complex network structure in both bacterial and phoD communities. The Mantel test, RDA, and PLS-PM model identified soil pH, electrical conductivity (EC), organic phosphorus (OP), available phosphorus (AP), total nitrogen (TN), microbial biomass carbon (MBC), and clay content as the main driving factors influencing changes in the rhizosphere bacterial community diversity and network structure.
Conclusion
These findings provide a theoretical basis for future research aimed at improving soil quality and cotton yield.
RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation
Authors: Orlacchio Arturo , Kajimura Yasuko , Rizzotto Lara , Tessari Anna , Soliman Shimaa H.A. , Visone Rosa , Zhang Liwen , Fries Brian , Tessarollo Lino , Amann Joseph , Carbone David P. , Lodi Alessia , Ahmed Amer , Fiermonte Giuseppe , Freitas Mike , Palmieri Dario , Kaufman Jacob , Coppola Vincenzo
Published: February 2025

Background
RANBP9 and RANBP10, also called Scorpins, are essential components of the C-terminal to LisH (CTLH) complex, an evolutionarily conserved poorly investigated multisubunit E3 ligase. Their role in non-small cell lung cancer (NSCLC) is unknown.
Methods
In this study, first we used stable loss-of function and overexpression inducible cell lines to investigate the ability of either RANBP9 or RANBP10 to form their own functional CTLH complex. Then, we probed lysates from patient tumors and analyzed data from publicly available repositories to investigate the expression of RANBP9 and RANBP10. Finally, we used inducible cell lines in vitro to recapitulate the expression observed in patients and investigate the changes of the proteome and the ubiquitylome associated with either RANBP9 or RANBP10 in NSCLC.
Results
Here, we show that the two Scorpins are both expressed in NSCLC cells and that either of them can independently support the formation of the CTLH complex. Short-term experiments revealed that the RANBP9 and RANBP10 proteins balance each other in terms of expression, and the acute overexpression of one or the other results in significant reshaping of the NSCLC cell proteome and ubiquitylome. A higher RANBP9/RANBP10 ratio is associated with greater proliferation in both NSCLC cell lines and patients. Acute increased expression of RANBP10 slows NSCLC cell proliferation and decreases the level of proliferation-associated proteins, including key players in DNA replication.
Conclusions
We present evidence that the Scorpins act as partial antagonists and work together as one sophisticated rheostat to modulate the CTLH complex ubiquitylation output, which regulates cell proliferation and other key biological processes in NSCLC. These results suggest that the two Scorpins can be considered as targets for the treatment of NSCLC.
Methyl Ethyl Ketone removal from Water via Pervaporation Using a Hydrophobic silicone-based Membrane
Authors: ShahBahrami Mohadese , Vahidi Omid , Farrokhzad Hasan , Poorkhalil Ali
Published: February 2025

The experimental study for the separation of methyl ethyl ketone (MEK) from water using the pervaporation membrane process with a polydimethylsiloxane (PDMS) membrane was conducted. Initially, several polymers were selected using Hansen solubility parameters, and ultimately, polydimethylsiloxane was chosen. In this study, ELASTOSIL® RT 601 A/B, which has a structure similar to polydimethylsiloxane, commercially known as Silgard 184, was used. This was confirmed through analyses such as FTIR, NMR, SEM, and water contact angle measurements, but the ELASTOSIL® RT 601 A/B was used at one-third of the price of Silgard 184. The feed was highly non-ideal and contained a heterogeneous azeotrope. The pervaporation experiments were performed at concentrations (5–15 wt%) and temperatures (40–60°C) under a vacuum pressure of 200 mbar. For a 5 wt% feed at 40°C, a total flux of 1.0208 kg/m²·h and a selectivity of 33 was achieved. Additionally, the effects of operational parameters, such as feed concentration and temperature, on the two factors of selectivity and flux were evaluated.
Effect of behavioural intervention package on empowerment and resilience among the pregnant women in India experiencing domestic violence: A facility-based randomized control trial
Authors: Mahapatro Meerambika , Roy Sudeshna , Nayar Poonam , Jadhav Ashwini , Panchkaran Suruchi , srivast divyanshu , Chandhok Gunjan , Prasad Sudha
Published: February 2025

Background
Women empowerment programs may reduce domestic violence (DV) by taking control of their lives. In a cognizant effort to empower pregnant women who have experienced DV, a Behaviour Intervention Package (BIP) was developed and used. It incorporates yoga-based techniques for self-development, interpersonal skill development, and awareness sessions. The study aims to assess the effects of a BIP on empowerment and resilience among pregnant women who have experienced violence and were attending antenatal care at a tertiary care hospital in India.
Methods
A randomised controlled trial was conducted with 211 pregnant women recruited between 18 to 20 weeks of pregnancy and randomly assigned to intervention (n = 105) or control (n = 106). The intervention group received behavioural intervention and standard care, while the control group received only standard care for 28 weeks. The study tools were completed once before the intervention and again at six weeks postnatal. The assessments were compared using methods as appropriate to estimate the effect size at baseline and post-intervention.
Results
The results showed that at a personal, relational, and socio-environmental level, the BIP intervention effectively improved quality of life, reduced DV, reduced stress and depression, and all parameters enabled women to develop a positive self-perception. They also reported being resilient and hopeful about their future.
Conclusion
The BIP may effectively empower pregnant women from low socioeconomic backgrounds facing DA in India, enhancing their quality of life. With no standardized intervention currently available, the BIP can be implemented in supportive settings to address the psychosocial health needs of women in distress and protect their health.
Trial registration
The Indian Registry of Clinical Trials number is CTRI/2019/01/017009 dated 9.1.2019.
Comparison of the Effects of CO2 Laser, Eggshell Nanoparticle Gel, and Their Combination on the Microhardness of Enamel White Spot Lesions
Authors: Taher Duaa , Abbas Dalia Kudier
Published: February 2025

Objective
The aim of this study was to evaluate the effect of chicken eggshell nanoparticle gel, CO2 laser and their combination on human enamel white spot lesions.
Material and methods
To produce white patches on tooth enamel, thirty maxillary first premolars were divided into three groups at random and then kept in a demineralizing solution. Eggshell nanoparticle gel was used in the first group, CO2 laser irradiation was used in the second, and CO2 laser and eggshell nanoparticle gel was used in the third. After that, teeth were submerged in synthetic saliva for 30 days. The enamel surface's Vickers hardness was measured. One sample from each group was analyzed using a scanning electron microscope (SEM) to display the morphological characteristics of the enamel surface. X-ray diffraction test (XRD) was made for one sample from each group to determine the crystallographic structure of the enamel. Tukey's test and two-way analysis of variance (ANOVA) were used to assess the data.
Results
After demineralization, the microhardness of enamel white spot lesions decreased significantly, and all three groups exhibited a significant difference between the demineralization and treatment stages, with a p-value of 0.000 for each group. The microhardness of enamel white spot lesions increased in all three groups.
Conclusion
Using eggshell nanoparticle gel, CO2 laser and CO2 laser with eggshell nanoparticle gel is suggested to reharden the tooth enamel. All the studied groups showed a comparable non-significant difference among them.
Intranasal Insulin and Budesonide Combination Films for Treatment of Anosmia: Randomized Clinical Trial
Authors: Ismail Mostafa , Abdelkarim Abdelrahim A. , Hamead Khalaf , Adel Amr , Badawi Ahmed M. , Mohamad Soad A.
Published: February 2025

Background: Smell is strongly related to quality of life. Therefore, anosmia has been considered one of the serious health conditions. Different treatment regimens were used as auxiliary therapy for improving olfaction but were not approved as final treatments. Recently, intranasal insulin has been developed as a treatment of anosmia. The purpose of this study is to present a more specific, effective, and safe treatment for anosmia, by adding strong steroid to insulin in the same film. This study was conducted on 40 patients with post-viral anosmia. Methodology was built-in multiple steps: study compatibility between steroid and insulin, preparation and characterization of intranasal films, and clinical assessment. Patients were randomly allocated into 2 parallel groups; intervention and placebo groups, both underwent endoscopic placement of intranasal insulin-budesonide combination films and saline films into the olfactory cleft, respectively. The procedure was performed for 8 sessions with 2 weeks interval.
Results: The results of compatibility and film characterization showed compatible combination in addition to flexible, homogenous, and controlled-release films. Clinical assessment showed significant improvement of intervention group compared to control group in both butanol test and olfactory discrimination test (p value 0.004 in the second visit and P<0.001 in the third visit, respectively).
Conclusion: According to our results, it can be concluded that a combination of anti-inflammatory steroids and growth factor elevator as insulin can be used as safe and effective combination for smell restoration.
Biomechanical Comparison Between Rim Plating and Posterior Buttress Plating for Posterolateral Tibia Plateau Fractures
Authors: Yoon Yong-Cheol , Kim Youngwoo , Chon Chang-Soo , Cho Jae-Woo , Oh Chang-Wug , Oh Jong-Keon
Published: February 2025

This study aimed to evaluate the biomechanical efficacy of rim plating for posterolateral tibia plateau fractures (PLTPFs) compared to conventional posterior buttress plating. Sixty synthetic tibial models were divided into three groups: posterior buttress plating with a 3.5-mm locking compression T-plate, rim plating with a 2.7-mm variable-angle cloverleaf plate and two anteroposterior screws, and rim plating alone. Static compression and cyclic loading tests were conducted to assess mechanical stability under simulated physiological conditions. Failure loads averaged 2235.75 N, 2017.46 N, and 1743.95 N for the groups, respectively, all exceeding the 1500-N threshold corresponding to approximately 250% of body weight in vivo. Cyclic loading showed minimal displacements across groups, with no significant differences in stability. Rim plating demonstrated slightly lower failure loads than traditional posterior buttress plating but provided sufficient biomechanical support for PLTPFs. Its performance under both static and cyclic loading indicates it is a feasible alternative, offering adequate stability while potentially reducing surgical invasiveness. These findings support the consideration of rim plating as a practical option for optimizing PLTPF management, balancing mechanical requirements with less invasive surgical techniques.
Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation and Experiment Verification Analysis to Reveal the Action Mechanism of RenShen Guipi Wan in treating Anaemia
Authors: Qu Tingli , Zhang Nan , Li Chen , Liu Xuyuan , Yun Keming , An Quan
Published: February 2025

Objective: To identify the possible phytochemical compounds of RGW that might treat anaemia through integrating network pharmacology, molecular docking, molecular dynamics simulation, and experiment verification to explore their potential mechanisms of action.
Methods: UPLC-Q Exactive Orbitrap-HRMS was used to identify RGW components. The major chemical components and potential target genes of RGW were screened by bioinformatics. The key targets in anaemia were identified based on network modules. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed. Pharmacodynamics was evaluated by establishing a micemodel of anaemia. Molecular docking, Molecular dynamics simulation, and Enzyme-linked immunosorbnent assay (ELISA) method were performed to confirm the effectiveness of targets in related pathways.
Result:171 compounds were identified in RGW using UPLC-Q Exactive Orbitrap-HRMS, eighty-two active ingredients in RGW were screened, 348 potential targets were identifed. In particular, Ginsenoside Rg4, Ginsenoside Rg1, 3,3',4,4'-Tetrahydroxy 2-methoxychalcone, Ginsenoside F1, Glycyrol, Chalconaringenin 4'-glucoside, Licochalcone B, 4',7-Dihydroxyflavone, Glycycoumarin, and Ginsenoside Rh1 were the core components and TP53, STAT3, PIK3R1, SRC, HIF-1α were the core targets. The GO and KEGG analyses indicated that RGW may modulate multiple biological processes and pathways, including the PI3K-Akt signaling pathway, HIF-1 signaling pathway, EGFR tyrosine kinase inhibitor resistance, and NF-kappa B signaling pathway. Molecular docking and molecular dynamics simulations showed good afnity between the active components and core targets of RGW, with stable binding within 100 nano seconds. Experiment verification revealed RGW could improve the routine blood markers of mice, and decrease the level of HIF-1α significantly.
Conclusion: RGW might play a role by targeting the key target HIF-1α and regulating PI3K-Akt signaling pathway and HIF-1 signaling pathways. This study demonstrates the potential pharmacological mechanism of RGW in the treatment of anaemia and provides a reference for clinical application of the formula.
Gas-sensitive detection of gas pollutants (CO, CO 2 , N 2 O) by monolayer Ti-C 2 N -V : a DFT study
Authors: Liu Yan , Boi Filippo , Zhang Leilei , Guo Lifen , Chen Lerui , Ma yanxia , Yang Biao , Mushtaq Muhammad
Published: February 2025

Recently, the use of efficient gas sensors to detect air pollutants has become one of the key steps for the timely identification of environmental problems. It is very meaningful to develop a gas-sensor that more accurately and efficiently detects certain air pollutants in the environment that are harmful to the human body. In this work, we report on the properties of a novel high-performance gas sensor (Ti-C2N− V) for detection of gas pollutants (CO, CO2, N2O) by using first-principles calculation methods of density functional theory (DFT). The binding energy, recovery time (τ), density of state (DOS), differential charge density, conductivity (σ) and gas sensitivity (S) were investigated. These results provide important insights on the sensitivity of Ti-C2N− V to these three gases is CO2 > CO > N2O. Interestingly, we demonstrate that their sensitivity exhibits values up to 1.61×108, 1.99×1012, and 8.75×1012 at room temperature. The results show that Ti-C2N− V monolayer material has great potential as an efficient gas sensor to effectively monitor these three harmful gases, providing a theoretical basis for the practical application of Ti-C2N− V monolayer as a high-efficiency gas sensor for CO, CO2 and N2O.
The Role of Research Process Presentations in Science Education: Perceptions of Credibility and Tentativeness in Research Findings
Authors: Thomas Julia Cathérine , Düsing Katharina , Bogaert Vanessa van den , Greving Hannah , Bruckermann Till , Schumann Anke , Brandt Miriam , Lewanzik Daniel , Voigt Christian , Kimmerle Joachim
Published: February 2025

Laypeople often struggle to understand the provisional nature of scientific knowledge. While scientific knowledge may be widely accepted within the scientific community, it is continually subject to revision and further development as new studies are published. These characteristics of science, where findings build upon each other over time rather than being entirely replaced by new discoveries, are not always well understood by the public. This becomes particularly problematic when research process presentations that emphasize the evolving, provisional nature of scientific knowledge are perceived as less credible, reinforcing misconceptions about the integrity and nature of science. In two experimental online studies on science education (n1 = 99; n2 = 184), we examined how different representations of the scientific process affect perceptions of credibility and tentativeness using text- and video-based presentations in the context of bat ecology as an example. In both studies, we varied the presentation of scientific practices (without explanations vs. with explanations) and the portrayal of the scientist’s deliberations (canonized vs. authentic). Our findings indicate that, although scientific knowledge is perceived as provisional, the way it is communicated can influence its perceived credibility. In both studies, perceived tentativeness was negatively correlated with perceived credibility, highlighting a challenge in science communication: the need to convey the evolving nature of scientific knowledge without undermining trust in its reliability.
Empowerment Program about Health Risks of Global Warming and Sustainability Practices among Nurses Providing Maternal and Child Health Services
Authors: –Nasr Eman Mahmoud Seif El , Shaban Marwa Mamdouh , Nour Rania Abd Elmohsen Abo El , Mohamed Sayeda Mohamed , Baraka Nagwa Ibrahim Mabrouk , baraka Samia Ibrahim Mabrouk
Published: February 2025

Background
Global warming poses a severe and escalating threat to human health worldwide, affecting both direct and indirect aspects of human well-being. This study aimed to evaluate the effect of empowerment program about health risks of global warming and sustainability practices among nurses providing maternal and child health services.
Methods
Employing a quasi-experimental design, a purposive sample of 100 nurses working in maternal and child health services in Tanta City. The research was approved by the ethical committee of the faculty of nursing with IRB number: RHDIRB555-11-2024. The study was conducted across all (6) healthcare facilities providing maternal and child health services in Tanta City. Data was collected using adapted tools including the Self- Nurses Knowledge Interview Questionnaire, and the Environmental sustainability practices questionnaire. Demographic characteristics were analyzed, and pre- and post-intervention scores were compared using paired t-tests were statistical methods.
Results
There was a statistically significant correlation between knowledge levels regarding global warming and environment sustainability practices among the studied nurses before, immediate post and after three months of empowerment program.
Conclusion
The study’s findings conclude that implementation of the empowerment program improves nurses’ knowledge regarding global warming and sustainability practices among nurses. The findings suggest a continuous in-service training program for nurses regarding global warming as well as other sustainable development goals and their impact on health, to promote sustainable development.
Compensatory Hyperhidrosis Following Endoscopic Thoracic Sympathectomy: A 5-Year Follow-Up Study of Risk Factors and Symptom Progression
Authors: Wu Jian-Yang , Xiong Jun-Kai , Huang Cheng-Bin , Wu Shao-Hang , Ou Yang-Sheng , Chen Zhi-Zhou , Xu Zhi-Yang , Xu Jian-Xin
Published: February 2025

Background
Compensatory hyperhidrosis (CH) is a common complication after endoscopic thoracic sympathectomy (ETS) for hyperhidrosis. Despite its prevalence, long-term data on CH progression and associated risk factors are scarce. This study evaluates the risk factors and progression of CH during a 5-year follow-up period.
Methods
This study retrospectively analyzed 138 patients with primary palmar hyperhidrosis (PPH) who underwent endoscopic thoracic sympathectomy between January 2014 and December 2019. All patients underwent bilateral single-port thoracoscopic sympathectomy and were followed up at 1, 3, and 5 years postoperatively. The severity of postoperative sweating was assessed using the Hyperhidrosis Disease Severity Scale (HDSS). Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the development and progression of CH.
Results
A total of 138 patients were included in the study, with 78.9% reporting the occurrence of CH after surgery and 23.8% of them experiencing severe CH. HDSS scores increased over the 5 years postoperatively, with symptoms worsening. Further analysis revealed that bilateral R4-level sympathectomy significantly increased the risk of CH progression (OR = 4.28, 95% CI: 1.27–15.60, P = 0.021) while having three or more affected areas was identified as a protective factor (OR = 0.19, 95% CI: 0.05–0.63, P = 0.008).
Conclusion
This study found that compensatory hyperhidrosis is relatively common in patients undergoing ETS, and symptoms may progressively worsen over time. The level of sympathetic nerve resection and the number of affected areas are key predictive factors for worsening symptoms.
Magnitude and factors associated with the uptake of the HPV vaccine among adolescent girls aged 13-17 years in Sheema Municipality, Sheema District. A cross-sectional study
Authors: Cherop Calvin , Kigongo Farida , Mugema Edgar Mulogo , Mugabe Rashid , Taremwa Bridget , Tusasirwe Evelyn
Published: February 2025

Introduction
Human papilloma virus (HPV) is the most common sexually transmitted infection (STI). Globally, HPV affects millions of women in their late teens and early 20s. The use of the HPV vaccine is the only way to avert this trend. However, the uptake of HPV vaccination is reportedly low in Uganda. This study therefore assessed the magnitude and factors associated with the uptake of the HPV vaccine among adolescent girls aged 13–17 years in secondary schools in Sheema Municipality, Sheema District.
Methods
A cross-sectional study was conducted among 293 adolescent girls aged 13–17 years in secondary schools in the Sheema Municipality. A pretested questionnaire was used for data collection. A proportional sampling technique was used to determine the number of adolescent girls selected from each school. Simple random sampling was used to enrol the respondents in the study. The data were entered into Microsoft Excel and analysed using Stata version 14. Multivariate logistic regression was used to determine the factors associated with HPV vaccination uptake. Variables with p < 0.05 were considered significant.
Results
More than half (66%) of the participants had received the recommended two doses of the HPV vaccine. The factors associated with the uptake of the HPV vaccine included perceived risk of HPV (aOR = 1.73, 95% CI: [1.00–2.99], p = 0.048), receiving health education (aOR = 2.17, 95% CI: [1.23–3.83], p = 0.007), having parents/caretakers with secondary education (aOR:6.61, 95% CI: 1.57–27.8, p = 0.010), receiving tertiary education (aOR:5.56, 95% CI: 1.33–23.1, p = 0.019) and living in urban areas (aOR = 0.37, 95% CI: [0.21–0.65], p = 0.001).
Conclusion
This study revealed relatively high HPV vaccine uptake among adolescent girls, although it was still below the highest global rates. Completion of the HPV vaccine was more likely among those with educated parents, received health education, and those with perceived risk of HPV, whereas urban residency was linked to lower uptake. To improve vaccination rates, efforts should focus on increasing awareness through school-based health programs, conducting awareness campaigns on HPV risks and vaccine benefits, and addressing barriers to vaccine access in urban areas.
Psychological aspects of grazing in adolescents: Psychometric properties and measurement invariance of the Rep(eat)-Q in community and clinical samples
Authors: Félix Sílvia , Ramalho Sofia , Marôco João , Ribeiro Andreia , Afonso Nadine , Gonçalves Sónia , Conceição Eva
Published: February 2025

Background: Grazing is a disordered eating behavior associated with poor weight control, increased eating disorder psychopathology, and psychological difficulties in adults. Unfortunately, little is known about grazing in adolescence, which is aggravated by the lack of validated measures for this population. This study investigates the psychological aspects of grazing in adolescence and provides psychometric support for a brief self-report measure, the Rep(eat)-Q.
Methods: A community sample of middle/high school students (n=358, 55.6% females) and a clinical sample with overweight/obesity (n=204, 59.8% females), completed a set of self-report questionnaires assessing eating and psychological variables including the Rep(eat)-Q. Weight and height data were also collected (Community: Mz-BMI=.39, SD=.98; Clinical: Mz-BMI=2.39, SD=.74).
Results: Confirmatory factor analysis revealed an adequate fit [(χ2(107)=389.77; p<.001; CFI=.99; TLI=.99; NFI=.99; SRMR=.062; RMSEA=.098] for a second-order (grazing) model with two first-order factors (repetitive eating and compulsive grazing subscales) with good reliability (.85<α<.91). Metric and scalar invariance was confirmed, allowing comparisons between samples. Compared with clinical adolescents, community adolescents reported higher scores on the Rep(eat)-Q total (Community: M=1.86, SD=1.30; Clinical: M=1.53, SD=1.35; t (559) = -2.81; p = .005) and repetitive eating subscale (Community: M=2.04, SD=1.44; Clinical: M=1.52, SD=1.35; t (560) = -4.24; p ≤ .001). The Rep(eat)-Q total score and subscales scores were significantly positively correlated with disordered eating behaviors and attitudes and inversely correlated with intuitive eating, suggesting good convergent validity (.11<r<.63). Similarly, adolescents scoring higher on grazing also present more psychological distress and poor cognitive and emotional functioning (.15<r<.50). Psychological variables (i.e., depression, anxiety, and negative urgency) explained 21.8% of the variance in the grazing score, independent of sex, age, and BMI z-score [F(6, 490) = 22.87, p ≤ .001; R2 = .218].
Conclusions: The Rep(eat)-Q is a reliable self-reported measure for assessing grazing in adolescents. These findings provide further support for the conceptualization of grazing in the spectrum of disordered eating and psychopathology in adolescents.
Observation of Discarded Larvacean Houses in the Benthic and Pelagic Zones of Spitsbergen Fjords Using Drop-Camera Imagery
Authors: Deja Kajetan
Published: February 2025

This study documents a unique observation of abandoned Oikopleura vanhoeffeni (Chordata: Appendicularia: Oikopleuridae) houses found on the seabed of various Spitsbergen fjords. The investigation utilized data from 253 video stations collected during the Arctic summers from 2015 to 2021. Notably, the 2021 observations revealed that Oikopleura houses were present in both on the seabed and in the pelagic zones, with densities reaching up to 973 structures per square meter on the seabed, occasionally covering up to 100% of the inspected seabed surface. According to existing literature, such densities could contribute up to 58 mg of carbon per square meter. In regions of maximal house density, the water was found to contain significant mineral suspensions, which could potentially influencing the rate of house occlusion, production, and sedimentation. This phenomenon highlights another potentially significant connection between Arctic plankton and the intensification of meltwater runoff enriched with mineral suspensions, driven by the accelerating effects of climate warming. Moreover, this observation may contribute significantly to advancing the understanding of the carbon cycle in ecosystems such as the Spitsbergen fjords. Although short-living, this occurrence may play a important role for benthic organisms and and represents a notable example of benthic-pelagic coupling, underscoring its ecological significance.