bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of electronic learning devices and online learning properties with work-related musculoskeletal disorders (WMSDs): A cross-sectional study among Thai undergraduate students
Authors: Direksunthorn Thanyaporn , Polpanadham Panicha , Summart Ueamporn , Mahem Khannistha , Kempanya Pipatpong , A’la Muhamad Zulfatul , Wittayapun Yuwadee
Published: October 2023

Computers and mobile devices are becoming the primary instruments used by students worldwide in all facets of their working and learning activities. This study aimed to investigate the relationship between the use of electronic devices, the characteristics of learning properties, and the potential predictors of work-related musculoskeletal disorders (WMSDs) among Thai undergraduate students. In this cross-sectional study, data were collected using Microsoft Forms with an online self-administered scale. The research instrument comprised four categories: demographic and health history characteristics, online learning properties, psychological health, and perceived WMSDs. Using multistage sampling, 4,618 samples were collected from 18 schools nationwide. A total of 3,705 respondents were eligible for the analysis. Descriptive statistics, chi-square, and binary logistic regression analyses were used for the data analysis. The results showed that the majority of the respondents had online learning only in some semesters/subjects (67.3%), used mobile phones for learning (43.3%), had an appropriate desk workstation (66.1%), used non-office chairs (76.0%), spent prolonged periods sitting (91.6%), had a bent posture while sitting (78.2%), had a private working space/room (92.4%), had proper lighting (85.4%), and experienced normal levels of stress (81.1%). Overall, 42.1% of Thai university students experienced WMSDs in any area of the body in the prior 6 months. Six significant predictors (p = 0.05) of WMSDs were obtained from the multivariate analysis, including stress, use of electronic devices, bent posture, prolonged sitting, year of study, and online learning classes (The adjusted odds ratio ranged from 1.43 to 3.67). High-risk students who mostly used mobile learning devices should be prescribed interventions to reduce stress, develop postural awareness and skills, emphasize positioning solutions, and reduce extended sitting time. The results indicated that preventive measures are warranted and required because the risk predictors were identified as preventable.
The anti-platelet drug cilostazol enhances heart rate and interrenal steroidogenesis and exerts a scant effect on innate immune responses in zebrafish
Authors: Chang Wei-Chun , Chen Mei-Jen , Hsiao Chung-Der , Hu Rong-Ze , Huang Yu-Shan , Chen Yu-Fu , Yang Tsai-Hua , Tsai Guan-Yi , Chou Chih-Wei , Chen Ren-Shiang , Chuang Yung-Jen , Liu Yi-Wen
Published: October 2023

Rationale

Cilostazol, an anti-platelet phosphodiesterase-3 inhibitor used for the treatment of intermittent claudication, is known for its pleiotropic effects on platelets, endothelial cells and smooth muscle cells. However, how cilostazol impacts the endocrine system and the injury-induced inflammatory processes remains unclear.

Methods

We used the zebrafish, a simple transparent model that demonstrates rapid development and a strong regenerative ability, to test whether cilostazol influences heart rate, steroidogenesis, and the temporal and dosage effects of cilostazol on innate immune cells during tissue damage and repair.

Results

While dosages of cilostazol from 10 to 100 μM did not induce any noticeable morphological abnormality in the embryonic and larval zebrafish, the heart rate was increased as measured by ImageJ TSA method. Moreover, adrenal/interrenal steroidogenesis in larval zebrafish, analyzed by whole-mount 3β-Hsd enzymatic activity and cortisol ELISA assays, was significantly enhanced. During embryonic fin amputation and regeneration, cilostazol treatments led to a subtle yet significant effect on reducing the aggregation of Mpx-expressing neutrophil at the lesion site, but did not affect the immediate injury-induced recruitment and retention of Mpeg1-expressing macrophages.

Conclusions

Our results indicate that cilostazol has a significant effect on the heart rate and the growth as well as endocrine function of steroidogenic tissue; with a limited effect on the migration of innate immune cells during tissue damage and repair.
Significant wave height prediction from X-band marine radar images using deep learning with 3D convolutions
Authors: Kwon Ji-Woo , Chang Won-Du , Yang Young Jun
Published: October 2023

This research introduces a deep learning method for ocean wave height estimation utilizing a Convolutional Neural Network (CNN) based on the VGGNet. The model is trained on a dataset comprising buoy wave heights and radar images, both critical for marine engineering. The dataset features X-band radar images sourced from Sokcho, Republic of Korea, spanning from June 1, 2021, to August 13, 2021. This collection amounts to 72,180 three-dimensional images, gathered at intervals of approximately 1.43 seconds. The data collected was highly unbalanced in terms of wave heights, with images of lower wave heights being more common. To deal with data imbalances in the wave height datasets, we categorized the data into three groups based on wave heights and applied stratified random sampling at each level. This approach balances the data patches for each training iteration, reducing the risk of overfitting and promoting learning from diverse data. We also implemented a system to protect data in groups with fewer instances, ensuring fair representation across all categories. This study presents a deep learning regression model for predicting wave height values from radar images. The model extracts features from sequences of 64 radar images using three-dimensional convolutions for both temporal and spatial learning. Using three-dimensional convolutions, the model captures temporal features in radar image sequences and provides accurate wave height estimates with an RMSE of 0.3576 m. The study derived results using radar images under different wave height conditions for 74 days to ensure reliability.
Virtual faculty development program in bioethics evaluated by Kirkpatrick model: A unique opportunity
Authors: Shallal Tara M. A. , Alkhateeb Nazdar Ezzaddin , Al-Dabbagh Ali
Published: October 2023

Background

With a shortage of teachers willing to deliver bioethics courses, particularly during the COVID-19 pandemic, faculty development in bioethics has become increasingly important for capacity building in medical education. This study aims to determine the impact of an online course on faculty development in teaching bioethics.

Methods

This quasi-experimental study involved twenty-six multidisciplinary faculty members who participated in an online bioethics course from January 4th to 22nd, 2022. Kirkpatrick’s evaluation model was used to assess the participants’ reactions, knowledge, and behavior, using online questionnaires and direct observation by expert faculty. SPSS 25 was used for data analysis.

Results

The Kirkpatrick evaluation model showed that the course was highly satisfactory in terms of content and delivery, with a significant improvement in clinical faculty’s knowledge from pre-test to post-test (14.18 ± 1.601 to 16 ± 2.049, p < 0.05). The participants demonstrated an improved range of teaching and learning methods.

Conclusion

The online course on bioethics successfully improved the clinical faculty’s knowledge and overall approach to teaching bioethics. These findings highlight the importance of well-constructed faculty development programs, particularly during times of resource constraint such as the COVID-19 pandemic.
The value of the neutrophil to lymphocyte ratio and PLT count for the diagnosis and prediction of COVID-19 severity
Authors: Chen Yingji , Han Pingyang , Gao Yunjie , Jiang Ruifeng , Tao Mei , Li Ximin
Published: October 2023

Background

COVID-19 and influenza A can cause severe respiratory illness. Differentiating between the two diseases and identifying critically ill patients in times of epidemics become a challenge for frontline medical staff. We sought to investigate whether both diseases and their severity could be recognized by routine blood parameters.

Methods

Our retrospective study analysed the clinical data and first-time routine blood parameters of 80 influenza A patients and 123 COVID-19 patients. COVID-19 patients were divided into three groups according to treatment modalities and outcomes: outpatient group, inpatient without invasive mechanical ventilation (IMV) group, and inpatient with IMV group. We used the Mann-Whitney and Kruskal-Wallis tests to analyze the differences in routine blood parameters between the two or three groups. Receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) were used to assess the diagnostic accuracy.

Results

Compared with outpatient influenza A patients, outpatient COVID-19 patients had a higher neutrophil to lymphocyte ratio (NLR) (6.63 vs 3.55). ROC analysis showed that the NLR had a high diagnostic value for differentiating COVID-19 from influenza A (AUC = 0.739). The best cut-off point of the NLR was 6.48, the diagnostic sensitivity was 0.523, and the specificity was 0.925. The median platelet (PLT) count in the different COVID-19 groups was as follows: outpatient group (189×109/L), inpatient without IMV group (161×109/L), and inpatient with IMV group (94×109/L). Multivariate logistic regression analysis found a significant association between PLT and treatment modality and outcome in COVID-19 patients (p<0.001).

Conclusions

NLR can be used as a potential biological indicator to distinguish COVID-19 and influenza A. Decreased PLT predicts the critical condition of COVID-19 patients and helps stratify the treatment of COVID-19 patients.
Cyasterone has a protective effect on steroid-induced Osteonecrosis of the femoral head
Authors: Sun Youqiang , Liang Mengmeng , Xing Yuemeng , Duan Yinfan , Zhang Shuangxiao , Deng Baogui , Xiang Xiaobing , Zhou Bengen
Published: October 2023

Context

Cyasterone alleviated the apoptosis of BMSCs induced by Dexamethasone via the PI3K/AKT signaling pathway. In addition, Cyasterone had a protective effect on SIONFH model rats by reducing the percentage of empty bone lacunae.

Objective

To study the effect of Cyasterone on apoptosis of rat BMSCs and its function on the SIONFH rat model.

Methods

Rat BMSCs were cultured and divided into Control, DXM and Cyasterone (DXM+Cyasterone) groups. The apoptosis of each group was detected by flow cytometry, the expressions of Caspase-3 and Caspase-9 were detected by immunofluorescence staining, and the mRNA and protein expressions of AKT, BAX, P53, P85, Bcl-2 and Cytochrome C were detected by qPCR and WB. In animal experiments, the femoral head of rats were subjected to HE staining and Micro-CT to observe the necrosis and repair conditions.

Results

The apoptosis rate of DXM and Cyasterone groups increased compared with Control group, and the apoptosis rate of Cyasterone group decreased compared with DXM group. Compared with DXM group, the mRNA expression of BAX, P53, P85 and Cytochrome C in Cyasterone group were increased, while the protein expression of AKT and Bcl-2 decreased. The histopathological and morphological analysis showed that Cyasterone promoted the trabecular bone structure in rat, which evenly benefit for the repair of SIONFH.

Conclusion

Cyasterone can reduce the apoptosis of rat BMSCs induced by Dexamethasone, and help promoting the bone repair in SIONFH rats.
Leveraging a smartphone to perform time-gated luminescence measurements
Authors: Fratto Brian E. , Culver Emma L. , Davis Gabriel , Deans Robert , Goods John B. , Hwang Sean , Keller Nicole K. , Lawrence John A. , Petty Alexander R. , Swager Timothy M. , Walish Joseph J. , Zhu Zhengguo , Cox Jason R.
Published: October 2023

Empowered by advanced on-board sensors, high-performance optics packages and ever-increasing computational power, smartphones have democratized data generation, collection, and analysis. Building on this capacity, many platforms have been developed to enable its use as an optical sensing platform for colorimetric and fluorescence measurements. In this paper, we report the ability to enable a smartphone to perform laboratory quality time-resolved analysis of luminescent samples via the exploitation of the rolling shutter mechanism of the native CMOS imager. We achieve this by leveraging the smartphone’s standard image capture applications, commercially available image analysis software, and housing the device within a UV-LED containing case. These low-cost modifications enable us to demonstrate the smartphone’s analytical potential by performing tasks ranging from authentication and encryption to the interrogation of packaging, compounds, and physical phenomena. This approach underscores the power of repurposing existing technologies to extend the reach and inclusivity of scientific exploration, opening new avenues for data collection and analysis.
The Expression and Function of Piezo Channels in Bladder
Authors: Li Zhipeng , Lin Dongxu , Luo Changcheng , Wei Pengyu , Deng Bolang , Li Kang , Cheng Langqing , Chen Zhong
Published: October 2023

The ability for bladder to perceive and analyze mechanical stimuli, such as stretch and filling, is crucial for its functions, such as urinary storage and voiding. The Piezo channel family, including Piezo1 and Piezo2, represents one of the most essential mechanosensitive ion channels in mammals and is involved in a wide array of physiological and pathological processes. It has been demonstrated in numerous investigations that Piezo channels play a key role in mechanical transduction in various types of cells in bladder by converting mechanical stimuli into biological signals. Notably, mounting evidence suggests that Piezo channels are functionally significant for bladder and are related to several bladder disorders. This review systematically summarizes the importance/role and features of Piezo channels in bladder, including their biophysical properties, location, and functions, with attention specifically paid to their association with the physiology and pathophysiology of bladder. This review aims to provide a novel perspective for the future clinical treatment of bladder dysfunction.
Book review of: Liefner, Ingo; Losacker, Sebastian (2023): Nachhaltige Wirtschaftsgeographie
Authors: Fuchs Martina
Published: October 2023

Buchreezension
Book review of: Rammert, Alexander (2022): Der Mobilitätsindex. Entwicklung eines integrierten Planungsinstruments für Mobilität.
Authors: Wilde Mathias
Published: October 2023

Buchrezension.
PENGARUH SOSIALISASI KESADARAN BERKESELAMATAN DI JALAN DALAM MEMBANGKITKAN SIKAP SAFETY RIDING PADA GENERASI Z
Authors: Arbaningrum Rizka
Published: October 2023

In fact, traffic accidents are a routine occurrence in the world and are one of the biggest causes of death in the world. Based on data obtained by WHO, traffic accidents cause 1.2 million deaths per year in low and middle income countries. 1000 deaths per day for under the age of 25 in the world so that traffic accidents are the highest cause of death for the category of children and adolescents in the age range of 5 to 29 years. However, one thing that is of concern is how to change the societal paradigm of traffic behavior so as to foster a culture of safety, especially from an early age. One of the strategic steps is through outreach to students from Kindergarten, Elementary, Middle School to SMA/SMK levels. The community service program is carried out at Pembangunan Jaya Middle School, located on Jl. Bintaro Utama 3A Pondok Karya Village, Pondok Aren sub-district, South Tangerang city. In socialization activities carried out at the initial stage and at the final stage by distributing pretest and posttest, of course this serves to find out the understanding of the material conveyed by the resource persons. Data processing from pretest and posttest results using IBM SPSS assistance by testing several testers. Of course, it is hoped that the results of the test will show understanding from the students of SMP Pembangunan Jaya so that later it can raise awareness about improving safety. Based on the results of the paired samples t test analysis using IBM SPSS in Figure 5, p = 0.00 (p <0.05), so that Ha is accepted and H0 is rejected, meaning that there is a significant influence on the socialization activities to raise awareness on road safety in Generation Z especially on the theme of Attitude towards Safety Riding.
Stability analysis, phase plane analysis, and isolated soliton solution to the LGH equation in mathematical physics
Authors: Islam S. M. Rayhanul , Ahmad Hijaz , Khan Kamruzzaman , Wang Hanfeng , Akbar M. Ali , Awwad Fuad A. , Ismail Emad A. A.
Published: October 2023

In this article, we investigated the Landau–Ginzburg–Higgs (LGH) equation, focusing on the analysis of isolated soliton solutions and their stability. To compute the isolated soliton solutions, we used the advanced auxiliary equation (AAE) approach, which has proven to be a powerful and efficient method for extracting soliton solutions in various nonlinear partial differential equations (NLPDEs). We provided a detailed explanation, both graphically and physically, of the obtained soliton solutions in this article. Furthermore, we used the linear stability technique to conduct a stability analysis of the LGH equation. Additionally, we studied the bifurcation and stability of the equilibria and performed phase plane analysis of the model. We also provided a discussion on the comparisons between the AAE method and two other well-known approaches: the generalized Kudryashov method and the improved Bernoulli sub-equation function method. The application of the AAE approach in this study demonstrates its effectiveness and capability in analysing and extracting soliton solutions in NLPDEs.
Selection of Key Performance Indicators for Your Sport and Program: Proposing a Complementary Process-Driven Approach
Authors: Clubb Jo , Allen Sian Victoria , Yung Kate K.
Published: October 2023

Key performance indicators (KPIs) are commonplace in business and sport. They offer an objective means to link data and processes with performance outcomes. Yet, their application in sports performance, particularly team sports, is not without issue. Here, we review 4 key issues relating to KPI application in team sports; lack of a universal definition, complexity of performance, drifting from on-field performance goals with off-field targets, and agency issues across different key stakeholders. With these issues relating to sports performance KPIs in mind, we propose a complementary approach to help practitioners focus on implementing the conditions that create performance environments and opportunities for success in a complex sporting environment. Ongoing process trackers (OPTs) are quantifiable measures of the execution of behaviors and processes that create the environments, cultures, and conditions for successful performance outcomes. This approach equips sports science practitioners with key questions they can ask themselves and their team when starting to select and use OPTs in their program.
Corrective Experiences to Enhance Trust: Clinical Wisdom From Good (Enough) Psychiatric Management
Authors: Choi-Kain Lois W. , Masland Sara R. , Finch Ellen F.
Published: October 2023

Unstable trust within social interchange underlies the symptom constellation of borderline personality disorder (BPD), resulting in preoccupation with intense dyadic relationships, limited capacity for social collaboration, and constricted social networks. Good Psychiatric Management (GPM) provides a distilled formulation of how interpersonal hypersensitivities drive the engine of BPD's symptomatic oscillations in both affect and attachment. The authors summarize clinically relevant conclusions from the empirical literature on trust in BPD, synthesize it with selected ideas from other empirically supported interventions, and distill a formulation of how the GPM approach can address problems of trust in BPD with strategies most clinicians can use to improve their work with patients. GPM's clinical management approach utilizes common factors in psychotherapy to structure collaboration with patients to be accountable partners in treatment, rely on themselves more to diminish unrealistic demands on others, and function more effectively in arenas that expand and stabilize their social network.
Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb
Authors: Cohen Oksana , Kahan Anat , Steinberg Idan , Malinowski Sebastian T. , Rokni Dan , Spehr Marc , Ben-Shaul Yoram
Published: October 2023

Social communication is crucial for the survival of many species. In most vertebrates, a dedicated chemosensory system, the vomeronasal system (VNS), evolved to process ethologically relevant chemosensory cues. The first central processing stage of the VNS is the accessory olfactory bulb (AOB), which sends information to downstream brain regions via AOB mitral cells (AMCs). Recent studies provided important insights about the functional properties of AMCs, but little is known about the principles that govern their coordinated activity. Here, we recorded local field potentials (LFPs) and single-unit activity in the AOB of adult male and female mice during presentation of natural stimuli. Our recordings reveal prominent LFP theta-band oscillatory episodes with a characteristic spatial pattern across the AOB. Throughout an experiment, the AOB network shows varying degrees of similarity to this pattern, in a manner that depends on the sensory stimulus. Analysis of LFP signal polarity and single-unit activity indicates that oscillatory episodes are generated locally within the AOB, likely representing a reciprocal interaction between AMCs and granule cells. Notably, spike times of many AMCs are constrained to the negative LFP oscillation phase in a manner that can drastically affect integration by downstream processing stages. Based on these observations, we propose that LFP oscillations may gate, bind, and organize outgoing signals from individual AOB neurons to downstream processing stages. Our findings suggest that, as in other neuronal systems and brain regions, population-level oscillations play a key role in organizing and enhancing transmission of socially relevant chemosensory information.

SIGNIFICANCE STATEMENTThe accessory olfactory bulb (AOB) is the first central stage of the vomeronasal system, a chemosensory system dedicated to processing cues from other organisms. Information from the AOB is conveyed to other brain regions via activity of its principal neurons, AOB mitral cells (AMCs). Here, we show that socially relevant sensory stimulation of the mouse vomeronasal system leads not only to changes in AMC activity, but also to distinct theta-band (∼5 Hz) oscillatory episodes in the local field potential. Notably AMCs favor the negative phase of these oscillatory events. Our findings suggest a novel mechanism for the temporal coordination of distributed patterns of neuronal activity, which can serve to efficiently activate downstream processing stages.
Evaluating STEAM-competence of prospective natural science teachers
Authors:   Belarusian State Pedagogical University named after Maxim Tank, Salahub Natallia Stanislavovna , Navumenka Natallia Vladimirovna ,   Belarusian State Pedagogical University named after Maxim Tank, Aizman Roman Idelevich ,   Novosibirsk State Pedagogical University
Published: October 2023

Introduction. The article studies the problem of developing STEAM competence in undergraduates pursuing their first degree in natural science education. The authors justify the necessity of introducing the discipline called ‘STEAM-approach in natural science education’ into the curriculum. The purpose of the article is to assess the readiness of future teachers of natural science subjects to implement STEAM education. Materials and Methods. The research methodology follows integrative, complex and contextual principles and the essential ideas of STEAM education aimed at the formation of STEAM-competencies in future natural science teachers. The authors summarized existing approaches to identifying key competencies, developed the structure of STEAM competence and designed the syllabus for ‘STEAM approach in natural science education’ discipline. The academic discipline ‘STEAM approach in natural science education’ was integrated in the curriculum of ‘Biology and Geography’ undergraduate programme and tested in the educational process. Final evaluating procedures which assessed the level of developing the components of STEAM competence included the comparative analysis of data obtained by means of questionnaires of teachers and students and the comparative assessment of some components of the STEAM competence in the control and experimental groups. Experimental work was conducted in secondary education settings in the Republic of Belarus and in the Faculty of Natural Sciences at Belarusian State Pedagogical University named after Maxim Tank. The study involved 33 natural science teachers and 70 undergraduates doing their first degrees in the Faculty of Natural Sciences at BSPU named after Maxim Tank. The methods of theoretical analysis, comparison, questionnaire, testing, and statistical data processing were used in the study. Results. In the course of the research, the need for the formation of STEAM competence in future teachers of natural science subjects is substantiated; a system of their preparation for the implementation of STEAM education is developed and justified. The results of experimental work confirm that the effectiveness of training future natural science teachers to implement STEAM approach is determined by academic disciplines, which involve students in STEAM education. Conclusions. The results obtained prove the effectiveness of developing STEAM competence in future natural science teachers by means of targeted method training provided at the first stage of higher education. Teaching ‘STEAM approach in natural science education’ discipline as one of the elements of future teachers’ method preparation for implementing STEAM education contributes to the improvement of their STEAM competence.
The Impact of the Covid-19 Pandemic on Vietnam’s Exports
Authors: Anh Tran Kim , Trang Le Mai , Tuan Hoang Anh , Hien Nguyen Thi , Ha Dinh Thi
Published: October 2023

The COVID-19 pandemic outbreak expanded worldwide, disrupting trade on a scale never before seen, as well as that of individual nations, notably Vietnam. The complicated developments of the COVID-19 pandemic have significantly affected Vietnam's economic growth in general and export activities in particular. Since joining the WTO, Vietnam's exports have grown tremendously and become an essential driver of economic growth. However, due to the high openness of the economy, Vietnam's exports are highly dependent on impacts from external shocks with global influence, especially the Covid-19 pandemic. The following research paper uses a mixed regression model to analyze and assess the impact of the Covid-19 pandemic on Vietnam's export activities through such contents as export turnover, export product, export market, and exporters.
The Impact and Response of Android Mobile Application Utilization of Health Consultations by Pregnant Women in Indonesia
Authors: Nurdiana Astri , Andriani Eka , . Carudin
Published: October 2023

The targets pertaining to Sustainable Development Goals for the period spanning from 2020 to 2021 have been revised downwards, notwithstanding a notable surge of 25 percent in the use of mobile-based health applications. Hence, the objective of this study is to create a mobile application called "Nutribid" that provides online counselling services for reproductive health and nutrition, specifically designed for Android devices. The participants of this research were 56 pregnant women residing in Purwadana Village, Indonesia, who utilised mobile devices equipped with the Android operating system. The findings indicate that a significant majority of the participants, above 90%, expressed agreement with the ease of identification, download, and use of the Nutribid application. Nevertheless, it is worth noting that a significant proportion, specifically 60.7% of the participants, expressed their dissatisfaction with the colour scheme employed in the application. Conversely, an overwhelming majority of the respondents concurred that the Nutribid application menu possesses commendable attributes such as ease of recognition, discoverability, legibility, and usability. The utilisation of mobile health applications has witnessed significant growth, yet, its integration into Indonesian society encounters many challenges attributed to the limited internet network infrastructure.
Brazilian Nursing Team: Quality of Working Life and The Leadership Influence
Authors: Rached Chennyfer Dobbins Abi , Manning Jennifer , Liberal Márcia Mello Costa De , RN Gabriella de Castro Sousa , RN Herline Domercant , Amaral Giovanna Micucci Pires
Published: October 2023

Objective: Analyzing the relation between the nurses-in-chief managerial styles with the Quality of Working Life (QWL). The balance between quality of life and work brings some sub-dimensions between life outside the workplace and work itself. Most of the investigated studies address the impact of work on life and the impact of life on the job. This analysis is important, as it contributes to several aspects, such as, for example, to increase the level of activity or participation. Materials and methods: Cross-sectional, qualitative, explanatory, and descriptive study. The sample was 61 nursing professionals (RNs) who held board positions, heads of department, managers, unit areas coordinators or supervisors, executive boards and/or departments, and 134 Licensed Practical Nurses (LPN) at a hospital with a direct public administration in Brazil. The data collection was based on The Quality of Working Life Questionnaire (QWLQ-brief) and the Scale of Evaluation of the Managerial Style (SEMS) forwarded electronically. Results: The indices considered satisfactory begin from 55 points. The QWLQ-brief average was 46,39% (neutral position), and the physical/health aspects were considered unsatisfactory (mean 44,89%; 44, 13%).Conclusion: The conclusion showed relational possibilities between the Nurse-in-chief managerial style and the perception of the Quality of Working Life. The perception of the neutral life quality and some unsatisfactory sub-dimensions was related to the managerial style based on tasks.
HIV Preexposure Prophylaxis Provision among Adolescents: 2018 to 2021
Authors: Kimball Anne A. , Zhu Weiming , Leonard Jerome , Wei Wei , Ravichandran Ishwarya , Tanner Mary R. , Huang Ya-Lin A. , Hoover Karen W. , Kourtis Athena P.
Published: October 2023

BACKGROUND AND OBJECTIVES

HIV preexposure prophylaxis (PrEP) is safe, effective, and was approved for adolescents in 2018. Adolescents and young adults make up 20% of HIV diagnoses in the United States. Our objective was to describe trends in adolescents prescribed PrEP during 2018 through 2021 and characteristics of these adolescents and their PrEP providers.

METHODS

We identified adolescents aged 13 to 19 years with oral PrEP prescriptions during 2018 through 2021 in a national pharmacy database using a validated algorithm. We assessed trends by calculating the overall percentage change and estimated annual percentage change with 95% confidence intervals. We described characteristics of adolescents and their PrEP providers in 2021. We performed χ2 analyses to assess differences by sex and age group.

RESULTS

The number of adolescents prescribed PrEP increased 76.2% from 2018 to 2021 (estimated annual percentage change: 18.0% [95% confidence interval: 16.6–19.5]), despite decreases in 2020. We observed increases among all sex and age groups, with larger increases among older adolescents aged 18 to 19 years. The majority of the 6444 adolescents prescribed PrEP in 2021 were male (82.6%) and aged 18 to 19 years (87.8%). Among 2455 physician PrEP providers, 29.6% were pediatricians, with varying specialty distributions by adolescent age group (P < .001). Among the 217 pediatricians who prescribed PrEP to adolescents aged 13 to 17 years, 67.7% were general pediatricians.

CONCLUSIONS

PrEP provision for adolescents has increased, largely among older and male adolescents. The availability of PrEP provides an important opportunity for pediatric providers to take an active role in HIV prevention.
Stable hydrogen isotope compositions of tourmalines from the Sopron metamorphic complex: Metamorphic closure temperature and fluid composition
Authors: Demény Attila
Published: October 2023

Stable hydrogen isotope compositions of metamorphic rocks and minerals can provide information on the origin of metamorphic fluids, which is especially important in systems that had experienced multiple metamorphic events. The Sopron orthogneiss-micaschist complex is a good target as it records signs of Variscan and Alpine metamorphic events as well as Variscan granitic magmatism. In this study tourmaline-bearing rocks (pegmatitic orthogneisses and kyanite-chlorite-muscovite schists) of the Sopron metamorphic complex were sampled and their tourmaline grains were analyzed for stable hydrogen isotope compositions (δ2H). The δ2H values (−23 ± 1‰, relative to V-SMOW) are in accordance with a fluid flux from devolatilization of subducted, seawater-containing rocks. Tourmaline-chlorite hydrogen isotope fractionations correspond to about 550 °C, indicating that δ2H values formed close to peak metamorphic temperatures are preserved without retrograde isotope exchange during cooling.
Expression of transcription factors involved in epithelial-to-mesenchymal transition of the breast cancer cell line MCF-7 co-cultured with adipose tissue mesenchymal stem cells
Authors: Tien Vu Thi , Hoang Duc Le , Van Ngoc Bui , Trung Nam Nguyen
Published: October 2023

Breast cancer is the most frequently diagnosed cancer in women globally. The tumor microenvironment plays a vital role in epithelial-to-mesenchymal transition (EMT), leading to the invasion and metastasis of cancer cells. The tumor microenvironment includes all components of the tumor cells, including the extracellular matrix, tumor vasculature, mesenchymal stem cells, immune cells, and fibroblasts. Understanding the interactions between mesenchymal stem cells and cancer cells is essential in determining the role of mesenchymal stem cells in diagnosing and treating breast cancer. In this study, we present the result of co-culture between adipose tissue mesenchymal stem cells (ADMSCs) and breast cancer cells (MCF-7 cell line) and determine the expression levels of transcription factors involved in EMT, including Twist and Snail. The results showed that the proliferation of MCF-7 co-cultured with ADMSCs was not increased compared to MCF-7 mono-cultured. Determination of gene expression levels by qRT-PCR revealed a significant increase in the EMT-related transcription factors (Twist and Snail) in breast cancer cells upon co-culture with ADMSCs. There were also significant differences between the expression levels of IL-6 and AhR in MCF-7 cells co-cultured with ADMSCs and MCF-7 cells mono-cultured. The results suggested that ADMSCs promoted the EMT of MCF-7 cells, potentially via AhR/NF-κB pathways.
Physiological quality of seeds from Passiflora mucronata Lam. genotypes with nitric oxide donor and salt stress
Authors: Lopes José Carlos , Oliveira Patrick Alves de , Alexandre Rodrigo Sobreira , Correia Aressa Oliveira , Canal Guilherme Bravim , Lima Paula Aparecida Muniz de
Published: October 2023

Abstract The presence of salts in the soil solution reduces the osmotic potential, hindering water absorption by roots. However, plants have defense mechanisms against stresses, releasing signaling molecules, in which nitric oxide plays an important role in the abiotic stress. This study aimed to assess the physiological quality of seeds from Passiflora mucronata Lam. genotypes pre-conditioned with the nitric oxide donor Tadalafil kept under salt stress. Seeds from nine P. mucronata genotypes evaluated under four nitric oxide donor Tadalafil concentrations : 0.0, 1.5, 2.5, 5.0, 7.5, 10.0 and 12.5 mg L-1, applied by soaking seeds for two hours, followed by washing in running water and germination in germitest® paper moistened with NaCl at -1.2 MPa. The experiment was carried out in a completely randomized design, with four replicates of 25 seeds. The nitric oxide donor Tadalafil, at concentrations of 1.5 and 2.5 mg L-1, increased the germination speed, shoot length, and dry mass. Pre-conditioning of seeds with the nitric oxide donor Tadalafil at concentrations of 5.0, 7.5, 10.0, and 12.5 mg L-1 determined the death of seeds. Seeds from genotype G3, pre-conditioned with Tadalafil at concentrations of 1.5 and 2.5 mg L-1, presented higher germination, germination speed index, mean germination time, shoot length, root length and dry matter values. Genotypes presented distinct phenotypic responses, providing intraspecific divergence.
Pathogenicity of reniform nematode (Rotylenchulus reniformis) on the stinking passionflower (Passiflora foetida)
Authors: Paes Bruno Scentinela Jacintho , Inomoto Mário Massayuki , Silva Aline Mayara Gonçalves Barros
Published: October 2023

Abstract Stinking passionflower (Passiflora foetida L.) is a medicinal species that may be used as rootstock to sour passion fruit (Passiflora edulis) against wilting and collar rot caused by Fusarium spp. However, as it is a host of the reniform nematode (Rotylenchulus reniformis), the cultivation of this species may be constrained in crop fields infested by this nematode. The objective of this study was to evaluate the effect of R. reniformis on the growth of stinking passion flower. The length of plants inoculated with the highest dose of each trial (152,900 and 78,900 specimens per plant corresponding to 402.4 and 207.6 specimens / cm3 of soil) was shorter than in plants not inoculated with the reniform nematode. Therefore, R. reniformis should be considered a pathogen of stinking passionflower and be properly managed.
Are stained and unstained methods of urine sediment from dogs in accordance with microbiological culture?
Authors: Soares Ana Bárbara Uchoa , Cargnelutti Juliana Felipetto , Albuquerque Bruno de Almeida , Andrade Cinthia Melazzo de , Hirata Vinicius Nomi
Published: October 2023

ABSTRACT: Diagnosis of bacteriuria in veterinary medicine is commonly based on unstained urinary sediment evaluation. Nonetheless, amorphous particles can be confused with bacteria. This study aims to investigate whether the stained sediment increases the sensitivity and specificity of bacteriuria detection. One hundred urine samples were collected, with 60 obtained through voided specimens and 40 through catheterization, from dogs of various breeds, genders, and ages. Additionally, a 1 ml aliquot from each sample was subjected to quantitative bacteriological culture, serving as the gold standard test for comparison with the sediment analysis. Comparing to the bacteriology culture, the stained sediment of urine collected by catheterization exhibited a relative sensitivity of 60% and specificity of 70%, while to voided specimens showed a sensitivity of 93.3% and specificity of 57.8%. Unstained sediment presented a sensitivity of 100% and specificity of 10% to urine collected by catheterization, and 93.3% and 4.4% to voided samples, respectively. Both stained and unstained methods demonstrated negative predictive values > 60%, but the positive predictive value of unstained sediment ranged to 24.6% (voided samples) to 27% (catheterization) indicating a lower probability of true positives. Both techniques showed a low correlation coefficient (kappa) indicating that they cannot replace the gold standard method for confirming bacteriuria. However, Gram staining of urinary sediment improved the differentiation between amorphous substances and bacteriuria in canine urine samples, suggesting its potential applicability in laboratory routines.
Comportamento face ao risco e estratégias de subsistência dos produtores de cacau biológico em São Tomé e Príncipe
Authors: Prazeres Ibrahim , Lucas Maria Raquel , Marta-Costa Ana , Henriques Pedro
Published: October 2023

Resumo O cacau é uma importante atividade sociocultural e económica em São Tomé e Príncipe (STP) e o maior contribuinte para o PIB e para as exportações do país. No entanto, os pequenos produtores ligados a esta cadeia de valor, pertencentes a duas cooperativas, enfrentam vários problemas e desafios relacionados à continuidade da produção de cacau biológico, com algumas vantagens relacionadas ao superior valor de mercado superior e sabor fino ou, à sua substituição por outras atividades mais produtivas e rentáveis. Este trabalho teve como objetivo analisar o comportamento face ao risco dos produtores de cacau biológico de STP no contexto das suas estratégias de subsistência, através da aplicação de um questionário a uma amostra de 230 famílias rurais. Os resultados mostraram não haver diferenças de governança entre as duas cooperativas. Um modelo teórico foi usado para determinar as relações entre as componentes de risco e as estratégias de subsistência. Os resultados mostram que as perceções de risco são mais importantes do que as atitudes de risco na decisão de estratégias de mitigação de risco. Além disso, as perceções desempenham um papel mediador entre as atitudes de risco dos agricultores e as estratégias de gestão de risco adotadas por eles. Estes resultados defendem medidas de política orientadas para as perceções de risco dos agricultores, a fim de implementar estratégias de gestão de risco bem-sucedidas.
PSICOLOGIA SOCIAL E ANTIRRACISMO: ARTE-FATOS CIENTÍFICOS DESDE CAOS-MUNDO
Authors: Lyra Jorge , Alves Míriam Cristiane , Sant'Anna Junior Ademiel de , Sousa Gioconda , Silva Juliana Keila Jeremias da , Prates Maíne Alves , Albuquerque Wellington
Published: October 2023

Resumo No presente manuscrito narramos em ficção experiências e questionamentos disruptivos que saboreamos com nossas corpas no processo de invenção e criação desse dossiê, que escuta e compartilha uma gama de possibilidades de “usos” do conceito de poder e de modos de subjetivação, seja na compreensão/vivência das relações raciais, na produção de estratégias de cuidado e de modos de existência de pessoas e comunidades negras, seja no enfrentamento ao racismo e às violências produzidas pela branquitude e pelos variados processos de atualização da lógica colonial. Caos-mundo é a encruzilhada, é a voz de criação, que protagoniza e fia conceitos diante de questionamentos sobre a Psicologia Social e do modo como tem trombado com a luta antirracista. Desde arte-fatos científicos, apresentamos o conjunto de artigos que constituem esse dossiê.
CORP(O)RALIDADE COMO METODOLOGIA: COMPOSIÇÕES POSSÍVEIS ENTRE ESCREVIVÊNCIA E FILOSOFIA UBUNTU
Authors: Santos Hebert Silva dos , Santos Loíse Lorena do Nascimento , Quadros Laura Cristina de Toledo , Tsallis Alexandra Cleopatre
Published: October 2023

Resumo Este artigo explora a Corp(O)ralidade como metodologia científica decolonial, ligada à filosofia Ubuntu e a escrevivência de Conceição Evaristo. Baseado na experiência do autor principal, em oficinas de dança afro no COART - UERJ, em 2019, e nas aulas on-line de Eliete Miranda durante a pandemia de covid-19 em 2020-2021. O trabalho é fruto de uma pesquisa de dissertação de mestrado (2020-2022), que reflete a construção de uma metodologia decolonial. A Corp(O)ralidade enfatiza a oralidade na dança afro, transmitindo os saberes ancestrais dos Orixás. A Teoria Ator-Rede é a metodologia, uma vez que valoriza todos na construção do conhecimento. O conceito Ubuntu destaca coletividade e solidariedade, conectando-nos aos outros. A Escrevivência de Conceição Evaristo compreende a oralidade negra e valoriza o conhecimento das mulheres negras. A pesquisa busca trazer a Corp(O)ralidade enquanto uma metodologia decolonial, que une os entendimentos da filosofia Ubuntu e a oralidade da escrevivência, ambos presentes da dança afro.
QUANTAS SOLIDÕES HABITAM A CORPA DE UMA TRAVESTI NEGRA E GORDA?
Authors: Nascimento Letícia Carolina Pereira
Published: October 2023

Resumo Este artigo é resultado de uma cartografia de si a partir de minhas experivivências como travesti negra e gorda no processo de compreender as diversas formas de solidão que atravessam minha subjetividade, desde a solidão estética, pensada por meio da ausência de representatividade, à solidão afetiva, decorrente do esvaziamento das possibilidades relacionais, mediante uma perspectiva romântica e além. Neste sentido, objetivo analisar os efeitos da colonialidade na produção de solidões e violências em minhas experivivências, enquanto apresento o Afrotranscentramento como uma possibilidade de cura às feridas coloniais. Metodologicamente, a cartografia possibilita mergulhar de forma encarnada em minhas experivivências, desenhando um mapa das afecções que povoam em mim na relação com as solidões. As experivivências afrotranscentradas provocam a clínica psi a romper com o pacto narcísico da branquitude cisheteronormativa. Nesta medida, o afrotranscentramento é um ébo de cura à carga colonial da solidão.
O que Pensa o Brasileiro sobre a Federação? Centralização e Crise de Confiança pós-2013
Authors: Ferrari Diogo , Schlegel Rogerio , Marta Arretche
Published: October 2023

Resumo As crises política e econômica que assolaram o Brasil nos últimos anos do governo Dilma resultaram em uma queda substancial nos níveis de confiança no governo central. Estes caíram de 57,10% em 2013, com Dilma Rousseff (PT) como presidente, para 13,35% em 2018. Este artigo investiga o impacto desse fenômeno sobre as atitudes dos eleitores em relação à distribuição de poder entre os níveis de governo no Brasil. Com base em dois surveys inéditos com representatividade nacional, mostramos que a queda de confiança no governo central reduziu o apoio ao aumento do poder da União na federação brasileira, mas, contraintuitivamente, não resultou em crescimento de atitudes descentralistas, em direção distinta da encontrada para o caso norte-americano. A crise de confiança no governo central que se instalou entre esses dois pontos no tempo mudou significativamente a importância da confiança como um fator preditivo de atitudes centralistas. Em conjunto, esses resultados mostram que a opinião pública sobre a federação não se opõe ao nível de centralização existente no Brasil, e também alertam para a importância dos choques de confiança para entendermos como esta última afeta a formação de atitudes centralistas.
Paulo Freire e a pedagogia latino-americana: a construção de uma identidade pedagógica
Authors: Streck Danilo Romeu
Published: October 2023

RESUMO O argumento neste ensaio é que a pedagogia de Paulo Freire representa tanto uma consolidação do pensamento pedagógico latino-americano quanto o ponto de partida para novos desenvolvimentos na área. O texto está divido em quatro partes. Na primeira, procura-se olhar como Paulo Freire constrói a sua visão de América Latina, com especial atenção para o tempo de exílio no Chile. A segunda parte trata de compreender o contexto de práxis na época em que se forma a pedagogia do oprimido, destacando a relação com a teologia e a pesquisa social. Segue-se a identificação de antecedentes da pedagogia do oprimido, exemplificando como a obra de Paulo Freire se constitui dentro de uma rica tradição pedagógica. Por fim, na quarta parte, são destacadas marcas da pedagogia latino-americana nas quais se faz presente de maneira mais evidente a presença de Paulo Freire. A conclusão aponta perspectivas para futuras pesquisas como seguimento do centenário do nascimento de Paulo Freire.