bluuebunny/crossref_metadata_2025 huggingface dataset:
SMU1 Knockdown Suppresses Gastric Carcinoma Growth, Migration, and Invasion and Modulates the Cell Cycle
Authors: Qian Meirui , Liang Xue , Zeng Qingmei , Zhang Chen , He Nan , Ma Jing
Published: September 2024

Introduction

The role of SMU1 in DNA replication and RNA splicing is well-established, yet its specific function and dysregulated mechanisms in gastric cancer (GC) remain inadequately elucidated. This study seeks to investigate the potential oncogenic and progression-promoting effects of SMU1 in GC, with the ultimate goal of informing novel approaches for treatment and diagnosis.

Methods

The study investigated the expression levels of SMU1 in GC and adjacent normal tissues by analyzing data from the TCGA (27 tissue pairs) and GEO (47 tissue pairs) databases. Immunohistochemistry was used to examine 277 tumor tissue and adjacent non-tumor tissue spots from GC tissue chips, along with relevant follow-up information. The study further assessed the proliferation, invasion, and migration capabilities of cells by manipulating SMU1 expression levels and conducting various assays, including CCK-8, EdU incorporation, colony formation, transwells, flow cytometry, and subcutaneous tumorigenesis assays.

Results

Our study revealed a significant upregulation of SMU1 mRNA and protein levels in GC tissues compared to adjacent tissues. Univariate and multivariate Cox analysis demonstrated that elevated levels of SMU1 were independent prognostic factors for GC prognosis ( P = 0.036). Additionally, median survival analysis indicated a significant association between high SMU1 expression and poor prognosis in GC patients ( P = 0.0002). In experiments conducted both in vivo and in vitro, it was determined that elevated levels of SMU1 can enhance the proliferation, invasion, and migration of GC cells, whereas suppression of SMU1 can impede the progression of GC by modulating the G1/S checkpoint of the cell cycle.

Conclusions

Our research introduces the novel idea that SMU1 could serve as a prognostic marker for GC progression, influencing cell proliferation through cell cycle activation. These results offer valuable insights into the understanding, diagnosis, and management of gastric carcinoma.
Dynamics and adaptive backstepping control of rotor-hybrid foil-magnetic bearings system
Authors: Guan Hanqing , Li Jiajun , Wei Kexiang , Chu Shenggui , Guan Yueqi , Wen Changyun
Published: September 2024

The hybrid foil-magnetic bearing (HFMB) is a contactless-type bearing composed of a foil bearing (FB) in the inner side and an active magnetic bearing (AMB) in the outer side. It has the advantages of low drag torque, high DN value (bearing inner diameter times rotating speed), and high supporting efficiency. However, significant subsynchronous vibration will degrade the stability of the rotor-HFMBs system, which is an obstacle to the industrial implementation of HFMBs. To control the rotor vibration, this paper presents a dynamic model of the rotor-HFMBs system with unknown parameters and the design of an adaptive backstepping controller (ABC) for it. The stability of the closed-loop system is established. Simulation results of the rotor-HFMBs system controlled by ABC are compared with the proportional-integral-derivative controller (PID), illustrating that the ABC is capable of eliminating rotor vibration, and it is more effective than the PID.
The coupled band gap of longitudinal wave in metamaterial-based double-rod containing resonators
Authors: Deng Ziwei , Zhang Baocheng , Zhang Kai , Peng Lei , Liu Peng , Sun Qihang , Pang Fuzhen
Published: September 2024

This study investigates the coupled band gap and vibration propagation characteristics of elastic waves in a metamaterial elastic double-rod system with attached periodic resonators. We derive the band gap structure and vibration attenuation equations of double-rod structure using the spectral element method, Bloch’s theorem, and the transfer matrix method. The validity of the coupled band gap is confirmed through forced vibration response analysis. Furthermore, we examine the effects of various parameters on the double-rod system, revealing that coupled band gaps exist with the average vibration attenuation rates of −50.23 dB for rod one and −47.87 dB for rod two, respectively. Remarkably, by adjusting the double-rod parameters, both the band gap frequency range and vibration attenuation ability of the coupled band gap can be adjusted to meet specific engineering requirements in low-frequency regions. This research contributes to developing continuous mechanical structures featuring coupled band gaps.
Maternal Reports to the Child Protection System: A Longitudinal Analysis of Multiple Children
Authors: Ahn Eunhye , Reddy Julia , Rebbe Rebecca , Palmer Lindsey , Putnam-Hornstein Emily
Published: September 2024

Child maltreatment can affect multiple children in a family, yet its occurrence and chronicity has been often assessed by focusing on a single child. Although this approach provides valuable insights, considering the experiences of all children in a family may provide a more complete understanding of maltreatment dynamics. Using linked birth and child protection system (CPS) records from California, we analyzed 20 years of data on 194,514 first-time mothers to document the prevalence, timing, and chronicity of maternal CPS reporting across multiple children. Mothers were categorized by the number of live childbirths: one (25.7%), two (36.2%), three (20.9%), and four or more (17.2%). Overall, 33.0% of mothers were reported to CPS, increasing from 18.5% for mothers with one child to 63.1% for those with four or more children. For mothers with two or more children, more than 70% experienced an initial CPS report only after the second child’s birth. Our findings have implications for understanding the dynamics of maternal reports to CPS, emphasizing the need for lasting and family-focused interventions.
Responding to Domestic Violence and Abuse during COVID-19 through Remote Interventions: An Evaluation of the Identification and Referral to Improve Safety (IRIS) Service
Authors: Rogers Michaela , Ali Parveen A.
Published: September 2024

Aim: To explore the perspectives of patients/service users receiving specialist domestic violence and abuse (DVA) support from the Identification and Referral to Improve Safety (IRIS) service during the coronavirus disease 2019 (COVID-19) pandemic. Design: A qualitative approach was used to conduct this study. Methods: Thematic analysis of data collected via in-depth individual interviews with 11 patients/service users who received DVA support following their disclosure of abuse to a health-care professional in general practice (GP) and subsequent referral to the IRIS service. Findings: Six themes were identified—experience of DVA during COVID-19; awareness of the IRIS service; pathway to care; accessibility, safety, and remote consultations; adequacy of telephone support; and impact of IRIS support. Participants reported feeling supported by the GP team and the DVA specialists from the IRIS service. Conclusion: The pandemic had a significant impact on health care and specialist DVA service providers. The swift shift to remote consultations proved to be an effective way to identify DVA, determine the support needs of those experiencing DVA from their own perspective, and make appropriate referrals for specialist support. Further research is needed to understand the views of health-care professionals and those working in the IRIS service to explore factors affecting their ability to provide remote services. The study highlighted the need for health-care professionals other than doctors (including nurses, midwives, and others) to build knowledge, confidence, and competence in asking about DVA.
The Banality of Data: Patient Records, Nursing, and Ideology
Authors: de Ruiter Hans-Peter , Breznik Melanie
Published: September 2024

This article explores nursing, patient records, and ideology within the context of the National Socialist “euthanasia” program ( Aktion T4) in Germany and Austria from 1939 to 1941, which targeted individuals with mental and physical disabilities for systematic killing. Using Hannah Arendt's concept of the “banality of evil,” it examines how ordinary individuals, including nurses, became agents of atrocity by adhering to bureaucratic orders. Jacques Ellul's Ethics of Technology framework is employed to analyze how National Socialist ideology manipulated technological processes to enhance efficiency in genocidal goals. Propaganda was crucial in garnering public support, blurring the lines between technology, ethics, and ideology. Archival research at documentation centers and national archives reveals methods for deciding who was killed, the role of family in medical records, and nurses’ involvement in the T4 operation. Three narratives of T4 victims illustrate the personal impacts of these bureaucratic and ideological practices. The article reflects on contemporary nursing, emphasizing the importance of ethical standards and vigilance against data and misuse of technology in health care. This historical examination serves as a reminder of the potential consequences of depersonalization and blind adherence to institutional priorities, underscoring the need for critical engagement with the ethical dimensions of nursing practice.
Development of an electromagnetic compatible composite-insert embedded in a double-curved sandwich panel
Authors: Mokhtari Majid
Published: September 2024

Composite sandwich structures, which are widely employed in engineering structures, require a multitude of inserts. In certain instances, the necessity for a specialized insert arises from the unique characteristics of a particular application. In applications such as weather radar radomes, double-curved sandwich panels should be designed with electromagnetic (EM) transparency as a primary objective. The use of metal inserts should be restricted to the absolute minimum. Given the limitations of using metal materials to protect against EM radiation and the need to enhance the load-bearing capacity of the joint against pull-out loads, a composite insert has developed as an innovative solution. In this study, a composite insert of a double-curved sandwich dome has been developed using silica nanoparticles, and its mechanical strength against pull-out load has been evaluated through both experimental and numerical analysis. The strength results obtained have been compared with analytical estimates. Additionally, the buckling of the double-curved sandwich dome against a wind speed of 220 km/h has been investigated numerically. The critical buckling load for wind loading for the full-scale sandwich radome was estimated to be 16,303 N. According to the numerical results obtained with the Abaqus finite element (FE) software, the maximum pull-out force applied to the connection area is approximately 10.7 kN. A parametric study of geometric variables and experimental results showed that it is possible to achieve a stronger composite insert (by 1 wt % nano silica particles) by 20.7% lighter and 102.65% more bearing capacity.
Impact response and compression-after-impact properties of foam-core sandwich composites incorporating scrap tyre rubber particles
Authors: Buddhacosa Nathaphon , Ibrahim Matthew , Charnsethikul Chananya , Santivongskul Parichamon , Khatibi Akbar , Das Raj , Kandare Everson
Published: September 2024

Integrating scrap rubber particles as fillers into polymer matrix composites offers a cost effective and environmentally sustainable pathway to manage tyre waste through the creation of value-added products. This research explores the low-velocity impact (LVI) response and compression after impact (CAI) properties of rubberised foam-core glass fibre-reinforced epoxy (GFRE) sandwich composites. Syntactic foam cores integrated with rubber particles were manufactured using vacuum-assisted resin transfer moulding (VARTM). The compression properties of rubberised foam core, vital for resisting impact damage during LVI, were examined. Results show more than 40% reduction in compression strength and modulus of the syntactic foam upon the inclusion of 33 wt.% rubber particles. The LVI response and residual compression properties of rubberised foam-core composites were also evaluated. Rubberised foam cores caused a marginal reduction in the peak impact force and led to approximately 60% reduction in the delamination area. The pre-impact compression strength was unaffected by rubber particles within the core as the GFRE face sheets carried most of the compression load. Post-impact compression strength was slightly higher in rubberised foam-core composites due to reduced delamination. Digital Image Correlation (DIC) analysis tracking of the strain evolution during CAI experiments revealed the stress-raising effect of the impact damaged region. This study showcases sustainable scrap tyre management through the inclusion of rubber particles into foam-core composites without substantially reducing in-plane compression properties before or after low-velocity impact.
Characterization of Expression-Based Gene Clusters Gives Insights into Variation in Patient Response to Cancer Therapies
Authors: Neary Bridget , Qiu Peng
Published: September 2024

Background:

Transcriptomics can reveal much about cellular activity, and cancer transcriptomics have been useful in investigating tumor cell behaviors. Patterns in transcriptome-wide gene expression can be used to investigate biological mechanisms and pathways that can explain the variability in patient response to cancer therapies.

Methods:

We identified gene expression patterns related to patient drug response by clustering tumor gene expression data and selecting from the resulting gene clusters those where expression of cluster genes was related to patient survival on specific drugs. We then investigated these gene clusters for biological meaning using several approaches, including identifying common genomic locations and transcription factors whose targets were enriched in these clusters and performing survival analyses to support these candidate transcription factor-drug relationships.

Results:

We identified gene clusters related to drug-specific survival, and through these, we were able to associate observed variations in patient drug response to specific known biological phenomena. Specifically, our analysis implicated 2 stem cell-related transcription factors, HOXB4 and SALL4, in poor response to temozolomide in brain cancers. In addition, expression of SNRNP70 and its targets were implicated in cetuximab response by 3 different analyses, although the mechanism remains unclear. We also found evidence that 2 cancer-related chromosomal structural changes may impact drug efficacy.

Conclusion:

In this study, we present the gene clusters identified and the results of our systematic analysis linking drug efficacy to specific transcription factors, which are rich sources of potential mechanistic relationships impacting patient outcomes. We also highlight the most promising of these results, which were supported by multiple analyses and by previous research. We report these findings as promising avenues for independent validation and further research into cancer treatments and patient response.
Comprehensive Analysis of CCAAT/Enhancer Binding Protein Family in Ovarian Cancer
Authors: Tan Jiahong , Wang Daoqi , Dong Wei , Nian Lei , Zhang Fen , Zhao Han , Zhang Jie , Feng Yun
Published: September 2024

Background:

Ovarian cancer has brought serious threats to female health. CCAAT/enhancer binding proteins (C/EBPs) are key transcription factors involved in ovarian cancer. Therefore, comprehensive profiling C/EBPs in ovarian cancer is needed.

Methods:

A comprehensive analysis concerning C/EBPs in ovarian cancer was performed. Firstly, detailed expression of C/EBP family members was integrally retrieved and then confirmed using immunohistochemistry. The regulatory effects and transcription regulatory functions of C/EBPs were studied by using regulatory network analysis and enrichment analysis. Using survival analysis, receiver operating characteristic curve analysis, and target-disease association analysis, the predictive prognostic value of C/EBPs on survival and drug responsiveness was systematically evaluated. The effects of C/EBPs on tumor immune infiltration were also assessed.

Results:

Ovarian cancer tissues expressed increased CEBPA, CEBPB, and CEBPG but decreased CEBPD when compared with normal control tissues. The overall alteration frequency of C/EBPs in ovarian cancer was approaching 30%. C/EBP family members formed a reciprocal regulatory network involving carcinogenesis and had pivotal transcription regulatory functions. C/EBPs could affect survival of ovarian cancer and correlated with poor survival outcomes (OS: HR = 1.40, P = .0053 and PFS: HR = 1.41, P = .0036). Besides, expression of CEBPA, CEBPB, CEBPD, and CEBPE could predict platinum and taxane responsiveness of ovarian cancer. C/EBPs also affected immune infiltration of ovarian cancer.

Conclusions:

C/EBPs were closely involved in ovarian cancer and exerted multiple biological functions. C/EBPs could be exploited as prognostic and predictive biomarkers in ovarian cancer.
Marine-Derived Furanones Targeting Quorum-Sensing Receptors in Pseudomonas aeruginosa: Molecular Insights and Potential Mechanisms of Inhibition
Authors: Boakye Aaron , Seidu Muntawakilu Padiga , Adomako Alice , Laryea Michael Konney , Borquaye Lawrence Sheringham
Published: September 2024

The quorum-sensing (QS) machinery in disease-causing microorganisms is critical in developing antibiotic resistance. In Pseudomonas aeruginosa, QS is involved in biofilm formation, virulence factors production, and general tolerance to antimicrobials. Owing to the major role QS plays, interference in the process is probably a facile route to overcome antimicrobial resistance. Some furanone-derived compounds from marine sources have shown promising anti-QS activity. However, their protein targets and potential mechanisms of action have not been explored. To elucidate their potential protein targets in this study, marine metabolites with furanone backbones similar to their cognitive autoinducers (AIs) were screened against various QS receptors (LasR, RhlR, and PqsR) using molecular docking and molecular dynamics (MD) simulation techniques. The order by which the compounds bind to the receptors follows LasR > RhlR > PqsR. Compounds exhibited remarkable stability against LasR and RhlR, likely because the AIs of these receptors are structural analogs of furanones. Furanones with shorter alkyl side chains bound strongly against RhlR. The presence of halogens improved binding against various receptors. PqsR, with its hydrophobic-binding site and structurally different AIs, showed weaker binding. This study provides a molecular basis for the design of potent antagonists against QS receptors using marine-derived furanones.
From Public Forecasts to Occupational Heat Safety Management: Evaluating the Effectiveness of the National Weather Service’s Operational Heat Risk Forecasts
Authors: Kim Yoojun , Ham Youngjib
Published: September 2024

Heat poses a major environmental risk to occupational safety, necessitating timely insights into associated risks to safeguard workers. In June 2022, the National Weather Service (NWS) initiated operational wet bulb globe temperature (WBGT) forecasts, offering valuable information for heat risk management. This study evaluates the effectiveness of NWS WBGT forecasts, aiming to identify potential areas of caution and improvements for their application for occupational safety management. To this end, the study examines 1.3 million hourly historical NWS WBGT forecast data, comparing it with observed data from 252 weather stations across the US during the summer of 2023. The results offer key insights, revealing that: (1) the accuracy of NWS WBGT forecasts is influenced more by the times of interest than by the forecast horizons; (2) NWS WBGT forecast accuracy varies across different climates in the US, with air temperature bias being the most influential factor in this inaccuracy; and (3) while NWS WBGT forecasts accurately identify the lowest heat risks (i.e. no heat risk), their performance decreases at higher risk levels, emphasizing the importance of careful interpretation in safety management. These insights offer guidance for more cautious interpretations of NWS WBGT forecasts and lay the foundation for future studies on leveraging operational weather forecasting services in effective heat mitigation strategies.
Media-Based Post-Event Impact Analysis of the 2021 Heat Dome in Canada
Authors: Tetzlaff Emily J , Goulet Nicholas , Gorman Melissa , Richardson Gregory RA , Enright Paddy M , Henderson Sarah B , Kenny Glen P
Published: September 2024

The unprecedented 2021 Heat Dome caused wide-ranging and long-lasting impacts in western Canada, including 619 confirmed heat-related deaths in British Columbia, a doubling of emergency medical calls, increased hospitalisations, infrastructure failures and stress on plants and animals. However, such varied socio-economic consequences of extreme heat can be challenging to capture using a single post-event analysis method. Therefore, there is a need to explore alternative approaches and data sources. Using the 2021 Heat Dome as a case study, a post-event analysis using online news media articles (n = 2909) from 5 subscription news databases and a grey literature search was conducted to identify the socio-economic impacts of the extreme heat event in Canada. The articles reported a wide range of effects to the natural environment (n = 1366), social infrastructure and services (n = 1121), human health (n = 1074), critical infrastructure (n = 988) and the private sector (n = 165). The media-based post-event analysis captured various impacts, some of which have not been identified through other data sources and approaches. Overall, we show that media analysis can complement traditional post-event analysis methods and provide additional perspectives to governments and public health and safety officials.
Identifying Patient Subpopulations with Significant Race-Sex Differences in Emergency Department Disposition Decisions
Authors: Lin Peter , Argon Nilay T. , Cheng Qian , Evans Christopher S. , Linthicum Benjamin , Liu Yufeng , Mehrotra Abhishek , Murphy Laura , Patel Mehul D. , Ziya Serhan
Published: September 2024

Background/objectives:

The race-sex differences in emergency department (ED) disposition decisions have been reported widely. Our objective is to identify demographic and clinical subgroups for which this difference is most pronounced, which will facilitate future targeted research on potential disparities and interventions.

Methods:

We performed a retrospective analysis of 93 987 White and African-American adults assigned an Emergency Severity Index of 3 at 3 large EDs from January 2019 to February 2020. Using random forests, we identified the Elixhauser comorbidity score, age, and insurance status as important variables to divide data into subpopulations. Logistic regression models were then fitted to test race-sex differences within each subpopulation while controlling for other patient characteristics and ED conditions.

Results:

In each subpopulation, African-American women were less likely to be admitted than White men with odds ratios as low as 0.304 (95% confidence interval (CI): [0.229, 0.404]). African-American men had smaller admission odds compared to White men in subpopulations of 41+ years of age or with very low/high Elixhauser scores, odds ratios being as low as 0.652 (CI: [0.590, 0.747]). White women were less likely to be admitted than White men in subpopulations of 18 to 40 or 41 to 64 years of age, with low Elixhauser scores, or with Self-Pay or Medicaid insurance status with odds ratios as low as 0.574 (CI: [0.421, 0.784]).

Conclusions:

While differences in likelihood of admission were lessened by younger age for African-American men, and by older age, higher Elixhauser score, and Medicare or Commercial insurance for White women, they persisted in all subgroups for African-American women. In general, patients of age 64 years or younger, with low comorbidity scores, or with Medicaid or no insurance appeared most prone to potential disparities in admissions.
Investigation of health care use and a possible prodrome before the first attack in NMOSD and MOGAD
Authors: Rotstein Dalia L , Freedman Mark S , Konig Andrea , Lee Liesly , Luo Jin , Maxwell Colleen , Morrow Sarah A , Tremlett Helen , Vyas Manav V , Marrie Ruth Ann
Published: September 2024

Background:

Prodromal phases are well recognized in many inflammatory and neurodegenerative diseases, including multiple sclerosis. We evaluated the possibility of a prodrome in aquaporin-4 antibody positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using health administrative data.

Methods:

We investigated individuals with AQP4 + NMOSD and MOGAD, confirmed by medical chart review, in Ontario, Canada. Each NMOSD and MOGAD participant was matched 1:5 to general population controls by sex, birth year, immigrant status, and region. Total outpatient visits and hospitalizations were compared in the 5 years preceding the incident attack in multivariable negative binomial models.

Results:

We identified 96 people with AQP4 + NMOSD, matched to 479 controls, and 61 people with MOGAD, matched to 303 controls. In the 5 years preceding the incident attack, health care use was elevated for outpatient visits and hospitalizations for the NMOSD cohort (adjusted rate ratio (aRR): 1.47; 95% confidence interval (CI): 1.25–1.73; aRR: 1.67; 95% CI: 1.19–2.36, respectively) but not for MOGAD. Rate ratios steadily increased in NMOSD for outpatient visits in the 2 years preceding the incident attack.

Conclusion:

Our findings support a prodromal phase preceding clinical onset of AQP4 + NMOSD. Earlier recognition and management of NMOSD patients may be possible.
The ankle–brachial index, gastrocnemius mitochondrial respirometry, and walking performance in people with and without peripheral artery disease
Authors: McDermott Mary M , Dayanidhi Sudarshan , Leeuwenburgh Christiaan , Wohlgemuth Stephanie E , Ferrucci Luigi , Peterson Charlotte A , Tian Lu , Sufit Robert , Zhao Lihui , Slysz Joshua , Polonsky Tamar S , Guralnik Jack M , Kibbe Melina R , Ho Karen J , Criqui Michael H , Zhang Dongxue , Xu Shujun , Greenland Philip
Published: September 2024

Background:

Mitochondrial abnormalities exist in lower-extremity peripheral artery disease (PAD), yet the association of the ankle–brachial index (ABI) with mitochondrial respiration in gastrocnemius muscle is unknown. The association of gastrocnemius mitochondrial respiration with 6-minute walk distance in PAD is unknown. This objective of this study was to describe associations of the ABI with mitochondrial respiratory function in gastrocnemius muscle biopsies and associations of gastrocnemius mitochondrial respirometry with 6-minute walk distance in people with and without PAD.

Methods:

People with (ABI ⩽ 0.90) and without (ABI 1.00–1.40) PAD were enrolled. ABI and 6-minute walk distance were measured. Mitochondrial function of permeabilized myofibers from gastrocnemius biopsies was measured with high-resolution respirometry.

Results:

A total of 30 people with PAD (71.7 years, mean ABI: 0.64) and 68 without PAD (71.8 years, ABI: 1.17) participated. In non-PAD participants, higher ABI values were associated significantly with better mitochondrial respiration (Pearson correlation for maximal oxidative phosphorylation PCI+II: +0.29, p = 0.016). In PAD, the ABI correlated negatively and not significantly with mitochondrial respiration (Pearson correlation for PCI+II: –0.17, p = 0.38). In people without PAD, better mitochondrial respiration was associated with better 6-minute walk distance (Pearson correlation: +0.51, p < 0.001), but this association was not present in PAD (Pearson correlation: +0.10, p = 0.59).

Conclusions:

Major differences exist between people with and without PAD in the association of gastrocnemius mitochondrial respiration with ABI and 6-minute walk distance. Among people without PAD, ABI and walking performance were positively associated with mitochondrial respiratory function. These associations were not observed in PAD.
‘Unsponsoring Football’: Sign Value, Symbolic Exchange, and Simulacra in a Gambling-Related Marketing Campaign
Authors: May Anthony
Published: September 2024

This article utilises Baudrillard’s concepts of sign value and symbolic exchange to examine the ‘Unsponsoring Football’ campaign which was designed by the marketing and creative agencies VCCP and Octagon, and carried out in conjunction with the bookmakers Paddy Power. Clubs were ‘unsponsored’ by Paddy Power, which paid for the right to not display its logo on football shirts. The campaign concept involved ‘spoof’ shirts which are simulations of the ‘real’ items. A four-step process through which the simulacra develop is outlined in the article. The campaign parodies UK government policy on gambling-related sponsorship, which has been criticised for its failure to regulate what is a globalised market. The 2023 White Paper ‘High Stakes: Gambling Reform for the Digital Age’ is notably similar to the parodic position taken in ‘Unsponsoring Football’. Removing some elements of sponsorship while retaining a wider relationship with the gambling industry means that the gamblification of the sport remains in place.
Students’ performance and English as a medium of instruction: Do students learn less?
Authors: García-Álvarez de Perea Juan , Ramírez-García Carolina
Published: September 2024

The European Higher Education Area (EHEA) is an EU initiative aimed at harmonizing university degrees and attracting international students and staff. Proficiency in the English language is now regarded as a pre-requisite for all business students. By adopting a quasi-experimental design, this article focuses on the effects that teaching Accounting in English as a foreign language (three groups totalling 52 students) may exert on Spanish students’ academic performance (measured through final exam grades), and compares it to the performance of peers having been taught in their native Spanish language (five groups totalling 70 students), where all groups have the same instructor. The impact of language on the students’ test scores is also considered. The findings show that the group using English as a medium of instruction (EMI) obtained better results, which suggests that, in this research context, the language of instruction does not seem to compromise students’ learning of academic content. Furthermore, the achievement of content regarding questions of a more conceptual nature is not dependent on language skills, which seems to contradict previous research. These findings may help foster the implementation of EMI courses, thereby encouraging both universities and students to partake therein. Suggestions are provided to enhance lecturer involvement, drawing on the lecturer’s pedagogical approach.
Characterizing self-reported physical activity before and during a subsequent pregnancy among parents in a familial autism cohort
Authors: G Bragg Megan , Vesey Olivia , Chavarro Jorge E , Hart Jaime E , Tabb Loni Philip , Weisskopf Marc G , Croen Lisa A , Fallin Daniele , Hertz-Picciotto Irva , Newschaffer Craig , Schmidt Rebecca J , Volk Heather , Lyall Kristen
Published: September 2024

Parents of autistic children report barriers to engaging in physical activity, which may be exacerbated during subsequent pregnancies. We aimed to describe physical activity of parents caring for an autistic child, before and during a subsequent pregnancy, and to explore whether physical activity was associated with the autistic child’s Social Responsiveness Scale score, a measure of autism-related traits. We used data from the Early Autism Risk Longitudinal Investigation, in which families with an autistic child were followed through a subsequent pregnancy. Mothers ( n = 245) self-reported physical activity in the 3 months before conception and during pregnancy; fathers ( n = 130) reported on the 6 months prior to enrollment. Approximately 40% of nonpregnant mothers and fathers and 9.3% of pregnant mothers met Physical Activity Guidelines for Americans recommendations. Most (83.5%) pregnant mothers reported no vigorous activity; after adjustment for covariates, this was more common among mothers of children with Social Responsiveness Scale T-scores >75 compared with mothers of children with lower T-scores (adjusted odds ratio (95% confidence interval) = 2.94 (1.11, 7.78)). Among parents caring for an autistic child before and during a subsequent pregnancy, physical activity was lower than recommended. Family-based interventions may be necessary to help support physical activity levels.

Lay Abstract

Parents of autistic children may have limited time and resources to participate in physical activity, a key aspect of health. Previous studies have been small and included mostly mothers, rather than fathers. No studies have examined physical activity in these parents during another pregnancy, when physical activity is especially important for maternal and fetal health. We aimed to fill this gap by examining physical activity levels among mothers and fathers caring for an autistic child before and during a subsequent pregnancy. We used data from a study which followed pregnant individuals who already had a child with autism. We asked mothers and fathers to report their levels of moderate and vigorous physical activity. We found that mothers and fathers of autistic children reported lower physical activity levels than the national average and were unlikely to meet Physical Activity Guidelines for Americans. Pregnant mothers were the least likely to participate in physical activity, particularly if their autistic child scored highly on a measure of autistic traits. Given that parental physical activity has benefits for parents and children, family-based interventions may be needed to help support parents’ physical activity levels.
Reporting community involvement in autism research: Findings from the journal Autism
Authors: Tan Diana Weiting , Crane Laura , Haar Tori , Heyworth Melanie , Poulsen Rebecca , Pellicano Elizabeth
Published: September 2024

Participatory methods are having sweeping effects on research across the globe. To facilitate transparency around these methods, Autism introduced mandatory reporting of community involvement in January 2021. Here, we sought to determine the impact of this policy. To do so, we – a team of Autistic and non-autistic researchers – searched for articles published in Autism in 2019, 2 years before policy implementation, and in 2022, 1 year after. We read 283 eligible articles and double coded each article for general information and details of community involvement. We found a fivefold increase (10.3% pre-implementation vs 54.5% post-implementation) in the reporting of community involvement. Most articles reported involving community members distally, in consulting roles, with researchers retaining full decision-making power. Furthermore, most community involvement was reported in more applied than basic research. A significant minority of papers (17%), however, could not be coded, owing to insufficient or vague information. While this increase in the reporting of community involvement is encouraging, more efforts need to be directed towards (1) improving the transparency in the reporting of community involvement and (2) increasing the frequency with which community members, especially Autistic people, share decision-making power equally with researchers – or even assume control of the research process.

Lay abstract

There has been a growing push for the Autistic and autism communities to be more actively involved in autism research. From January 2021, the journal Autism made it a rule for authors to report whether they involved community members in their work; and if they did, how they had done so. In this study, we wanted to see how this new rule has changed things. Our team of Autistic and non-autistic researchers read all 283 articles published in Autism in 2019, about 2 years before the rule was in place, and in 2022, about 1 year after. We recorded what each article was about and how the community was involved. We found there was an increase in how often articles talked about community involvement – from about 10% before the rule to over 50% after. Most of these studies, however, only involved community members giving advice, with the researchers making most decisions about the research. This was especially true for applied research (like wellbeing) rather than basic science (like causes of autism). Also, some of these articles were unclear or did not give enough information for us to understand how the community was involved. This tells us that while it is promising that more community involvement is reported, researchers need to describe this involvement more clearly. It is also important for community members to have a bigger say in research by sharing power with the researchers or even leading the research themselves.
Legitimation work in privatized criminal justice: Softening, shrinking, and signaling
Authors: Burkhardt Brett C.
Published: September 2024

How do private companies justify taking on criminal justice functions? Building on writing on legitimacy and privatization, this article describes three rhetorical practices intended to increase the legitimacy of private companies carrying out criminal justice functions: softening (obscuring the use of force); shrinking (demonstrating deference to the state); and signaling (proclaiming alignment with pro-social values). The article demonstrates the analytic utility of these categories by considering public-facing Environmental, Social, and Governance (ESG) reports produced by one prominent company in the private corrections industry (CoreCivic). The conceptual typology of legitimation work brings together several dynamics that are common in privatized criminal justice and provides an analytic toolkit for future study. A discussion considers how researchers can use this typology to examine legitimation work by other private firms and industries that engage the criminal justice system.
Why the post-identification era is long overdue: Commentary on the current controversy over forensic feature comparison as applied to forensic firearms examination
Authors: Biedermann Alex , Champod Christophe
Published: September 2024

In this commentary, we critically review recurring arguments for and against the discipline of forensic feature comparison as applied to firearms examination from various commentators within and outside forensic science. One of the mainstream criticisms that we address, among others, is that the field cannot demonstrate sufficient proficiency and robustness based on empirical (i.e., black-box) studies. While the lack of empirically demonstrated examiner proficiency is a valid concern and a powerful concept in the short term (e.g., in admissibility proceedings), many critics reduce their discussion of forensic feature comparison solely to the need to measure and demonstrate proficiency through error rates. However, the exclusive focus on aggregate expert performance metrics, here referred to as examiner diagnosticism, remains a surface-level perspective. It provides an incomplete account of the field because these metrics do not represent—but are often confused with—the notion of the evidentiary value of findings, i.e., observations made on examined items in individual cases. We argue that examiner diagnosticism should be contrasted and complemented with the notion of feature selectivity, i.e., the diagnostic capacity of observed marks and features on examined items. We argue that forensic scientists should report and be probed on their ability to quantify feature selectivity (i.e., the probative value of findings). By ceasing to express source attribution opinions (identification/individualisation), which are now widely exposed as unscientific, the forensic feature comparison disciplines could move further into the long-awaited post-identification era pioneered by other fields such as forensic genetics.
Relations among degree of bilingualism and bilateral information processing in children and adults
Authors: Sierra Francisco J. , Weimer Amy A. , Lin Yu-Cheng , Jou Jerwen , Castillo Nayda , Garcia Cedar , Suarez Michelle , Garcia Flor I. , Aleman Gabriela , Ortiz Edson , Romero Francheli
Published: September 2024

Aims and objectives:

The primary goal of this study was to examine whether degree of bilingualism related to dichotic listening accuracy, a measure of bilateral processing, after controlling for age and income.

Methodology:

Participants included 59 children ages 6–11 years ( M = 7.86, SD = 1.81) and 61 adults (18–83 years) ( M = 34.02, SD = 15.70). Participants completed demographic surveys, vocabulary assessments in English and Spanish, and a dichotic listening test.

Data and analysis:

Multiple linear regressions examined whether the degree of bilingualism predicted bilateral processing.

Findings:

Degree of bilingualism predicted bilateral processing in the whole sample of children and adults.

Originality:

This study is one of the first to examine bilingualism and bilateral processing while including both children and adults. It also importantly controlled for a possible cognate facilitatory effect and participant income differences and measured bilingualism on a continuum.

Significance:

Results highlight the importance of including bilingual groups of different ages when researching bilingualism and laterality.
Uncertain seismic response and robustness analysis of isolated continuous girder bridges
Authors: Long Xiaohong , Li Zonglin , Gu Xiaopeng , Chen Xingwang , Ma Yongtao
Published: September 2024

When calculating the seismic response of structures, conventional methods often neglect uncertainty and suffer from excessive computation. Although robustness metrics have been effective in evaluating structural safety, they are not suitable for isolated continuous girder bridges (ICGB). To address this issue, this paper introduces an uncertain seismic response and robustness assessment method tailored to ICGB: Firstly, the method considers uncertainty in material parameters and ground motion by constructing a data set using Monte Carlo simulation. Secondly, a genetic algorithm for parallel optimisation of radial basis function neural network (GAPO-RBFNN) is trained to predict the seismic responses of the bridges. Thirdly, a robustness metric specifically designed for bridges is derived and applied to bridge. Finally, the proposed robustness metric is validated on lead rubber bearing (LRB) and shape memory alloy-lead rubber bearing (SMA-LRB) bridges. Results indicate that the GAPO-RBFNN model accurately approximates the mapping relationship between structural parameters and seismic response, with an average error of only 0.32% and a 70% reduction in computation time compared with traditional methods. Moreover, the new robustness metric overcomes the limitations of the dismantled member method and is applicable to bridge. The robustness of the SMA-LRB-ICGB, strengthened by SMA, is improved, providing evidence of the effectiveness of the proposed robustness metric.
Experimental study on strengthening steel-truss bridge diagonal members using carbon-fibre-reinforced polymer bonding methods
Authors: Pham Ngoc Vinh , Ohgaki Kazuo , Miyashita Takeshi , Pham Ngoc Quang
Published: September 2024

This study investigated the effectiveness of carbon fibre-reinforced polymer (CFRP) materials in strengthening the diagonal tension members of steel-truss bridges. Monotonic tensile and cyclic loading tests were performed on CFRP-strengthened specimens with variations in the CFRP-bonding range on the flanges. This study focused on the strengthening methods A and B, which were proposed to address insufficient CFRP anchoring near gusset plates by bonding CFRP sheets to both sides of the flanges of the diagonal tension members. The results of the monotonic tensile loading tests indicated a significant increase in tensile stiffness and substantial improvements in yield strength (27%) and ultimate load-bearing capacity (51%) when the strengthening methods A and B were employed. Delamination of the bonded CFRP sheets was effectively delayed, occurring only after the steel yielded, owing to the use of a ductile adhesive (polyurea putty). On the other hand, the cyclic loading tests demonstrated a significant enhancement in the load-bearing capacities (33% for tensile, 32% for compressive) of the strengthened specimens. Moreover, the energy dissipation capacities of the specimens strengthened by methods A and B exhibited linear increases, with 12% and 14% higher values respectively than those of the non-strengthened specimen. Although the stiffnesses (tensile and compressive) of the strengthened specimens decreased in each loading loop, the strengthening methods A and B maintained the stiffness values at approximately 35% higher than those of the non-strengthened specimen.
The thermal responses of composite box girder bridges with corrugated steel webs under solar radiation
Authors: Cai Chenzhi , Xu Ming , He Xuhui , Zou Yunfeng , Huang Shiji
Published: September 2024

Owing to the direct exposure to complex atmospheric environments, the temperature field of composite box girder bridge with corrugated steel webs (CBGB-CSW) is likely non-uniformly distributed. Whereas, the current researches regarding the thermal responses of CBGB-CSW are insufficient, and the thermal responses of CBGB-CSW under solar radiation are still unknown. Therefore, this paper conducted a long-term temperature experiment on a scaled model to explore the temperature distribution characteristics in CBGB-CSW. Meanwhile, a three-dimensional thermal–mechanical coupling Finite Element (FE) model is established to simulate the temperature field in the experiment girder. The accuracy and effectiveness of the developed FE model has been verified by the measured temperature data. Therewith, the thermal responses (i.e., stress and displacement) of a full-scale continuous CBGB-CSW with a span of 150 m are numerically investigated. The results indicate that the maximum stresses always occur at the midspan section (with a depth of 5 m) of the continuous CBGB-CSW, and considerable concentrations of stress are observed in the steel-concrete junction. The maximum longitudinal tensile and compressive normal stresses within 0.4 m of the upper junction can reach 5.55 MPa and −8.46 MPa respectively, and those of the lower junction can reach 6.96 MPa and −7.05 MPa respectively. Besides, owing to the impacts of vertical and horizontal temperature gradients, significant displacements of the whole bridge can also be observed. The maximum vertical displacement (5.33 mm) of the CBGB-CSW is estimated at the top plate in the midspan, while the maximum horizontal displacement (0.74 mm) is estimated at the trough of the southern corrugated steel web in the midspan. Notably, the outcomes of this paper can provide some useful references for engineers and scholars to understand the thermal responses of the CBGB-CSW.
Fractal-fractional model for the receptor in a 3D printing system
Authors: Zuo Yu-Ting
Published: September 2024

A critical hurdle in three-dimensional printing is the low printing accuracy. In particular, the deformation of the printed object on the receptor makes accurate printing impossible due to insufficient solvent evaporation. We address this challenge by establishing a Murray-like receptor to control the morphology of the printed object, which can be used for accurate printing through efficient residual energy absorption and active vibration attenuation. A fractal oscillator is established and He’s frequency formulation is used to reveal the fractal response of the Murray-like receptor, and an experiment was carried out to show that the receptor system can keep the printed object in good shape without any deformation.