bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables S1-S5 from Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Authors: Gopal Y.N. Vashisht , Rizos Helen , Chen Guo , Deng Wanleng , Frederick Dennie T. , Cooper Zachary A. , Scolyer Richard A. , Pupo Gulietta , Komurov Kakajan , Sehgal Vasudha , Zhang Jiexin , Patel Lalit , Pereira Cristiano G. , Broom Bradley M. , Mills Gordon B. , Ram Prahlad , Smith Paul D. , Wargo Jennifer A. , Long Georgina V. , Davies Michael A.
Published: March 2023

Supplementary Tables S1-S5. Table S1. Patients in the MIA/WH cohort treated with BRAF and/or MEK inhibitors. Table S2. Patients in the MGH patient cohort were treated with the BRAF inhibitor vemurafenib or a combination of BRAF and MEK inhibitors (dabrafenib+trametinib). Table S3. The following melanoma cell lines with known BRAF and NRAS mutation status were seeded in 96 well plates overnight and treated with increasing concentrations (dose range 9nM-6.5mM) of selumetinib (SEL), AZD8055 or their combination. Table S4. Mutations detected in the selumetinib-resistant A375 and WM35 cell line clones compared to their parental cell lines. Table S5. Hugo gene symbols, chromosomal location and gene names of the 202 genes represented in the T200 exon sequencing panel.
Supplementary Figure 3 from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: March 2023

Supplementary Figure 3. This figure shows additional characterization of nucleosome positioning positions changes around transcription start sites in Brg1 KD cell lines.
Supplementary Figure S10 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: March 2023

Supplementary Figure S10. Association of CtBP2 binding sites with CtBP2 regulated genes.
Supplemental Figure S5 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: March 2023

Supplemental Figure S5. Related to Figure 4C-E: Primary breast tumors in Early SNAIL1 KO exhibit loss of EMT phenotype and metastatic potential
Figure S3. Elevated levels of reactive oxygen species are responsible for cell death in Tsc2-/- MEFs from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: March 2023

Glutathione measurement in Tsc2-/- cells treated with indicated compounds; GSH/GSSH measurement in Tsc2-/- MEFs
Figure S2 Inhibition of mTORC1 and glutamate cysteine ligase induces cytotoxicity in Tsc2-/- MEFs from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: March 2023

Cell viability of Tsc2-/- MEFs and WT MEFs treated with single agent and combination; siRNA-mediated knockdown of GCLC with or without rapamycin; cell viability of ELT3-V3 cells. Cell death study of ELT3-V3 vs. ELT3-T3 and 621-102 vs. 621-103
Figure S1 Identification of rapamycin collaborators through small molecule high-throughout screening from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: March 2023

Synergism analysis between BSO and rapamycin in Tsc2-/- MEFs
Supplementary Video 4 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: March 2023

Live cell microscopy of MDA-MB-468 inducibly expressing empty expression plasmid and transiently transfected with H2B-GFP. The movie shows aberrant anaphase.
Supplemental Table S1 from Targeting Cancer Stem–like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma
Authors: Cornaz-Buros Sandrine , Riggi Nicolo , DeVito Claudio , Sarre Alexandre , Letovanec Igor , Provero Paolo , Stamenkovic Ivan
Published: March 2023

Supplemental Table S1. Target genes of 5 TARBP2-dependent miRNAs.
Supplemental Figure S1 from Targeting Cancer Stem–like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma
Authors: Cornaz-Buros Sandrine , Riggi Nicolo , DeVito Claudio , Sarre Alexandre , Letovanec Igor , Provero Paolo , Stamenkovic Ivan
Published: March 2023

Supplemental Figure S1. Tumor origins and specifications and primary cell characterization.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Supplementary Figure S3. Validation of GL26-Cit cells independently transduced with gal-1-specific or control shRNA.
Data Supplement from Validation and Structural Characterization of the LEDGF/p75–MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia
Authors: Čermáková Kateřina , Tesina Petr , Demeulemeester Jonas , El Ashkar Sara , Méreau Hélène , Schwaller Juerg , Řezáčová Pavlína , Veverka Vaclav , De Rijck Jan
Published: March 2023

Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Table S1 from Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes
Authors: Kanterman Julia , Sade-Feldman Moshe , Biton Moshe , Ish-Shalom Eliran , Lasry Audrey , Goldshtein Aviya , Hubert Ayala , Baniyash Michal
Published: March 2023

Primers for quantitative Real Time PCR.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Supplementary Figure S5. Morphometric analysis of 48hr post-implantation intracranial GL26-Cit gliomas (shown in Figure 1G).
Supplementary Figures S1-S8 from Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes
Authors: Kanterman Julia , Sade-Feldman Moshe , Biton Moshe , Ish-Shalom Eliran , Lasry Audrey , Goldshtein Aviya , Hubert Ayala , Baniyash Michal
Published: March 2023

5FU and CPT11 display opposite effects on β-catenin localization in CRC colons (S1); 5FU and CPT11 display opposite effects on MDSC accumulation and CD247 expression in the colons of CRC-mice (S2); 5FU or CPT11 chemotherapies do not alter the elevated Treg levels in spleens from CRC-mice (S3); A combined 5FU and CPT11 therapy preserves immunosuppression (S4); A schematic representation of mouse model for CRC in which MDSCs were in vivo depleted in CPT11 treated mice by Gr1 mAb administration every 3 days (S5); 5FU and CPT11 differently affect monocytic/granulocytic MDSC sensitivity to apoptosis (S6); 5FU and CPT11 treatments display opposite effects on mRNA expression levels of pro-inflammatory molecules (S7); 5FU and CPT11 treatments differently affect the immunological profile of mice exhibiting a pathology free chronic inflammation (S8).
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: March 2023

Supplementary Figure 2. (A) IF of non-permeabilized KIJ265T cells for NPTX2 expression. (B) Relative NPTX2 expression values of patient gene array data sorted into low versus high NPTX2 expression groups. (C) IF for NPTX2 (far left panel) and Fibronectin (far right panel) in A498 NT vs. sh1316 NPTX2 knockdown cells. 60x magnification of regions highlighted in 20x images are shown (central panels).
Figure S3 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S3. Identification of a TRE (TGCGTCA) in the promoter of NRF2. The different human NRF2 promoter constructs were cloned upstream of a luciferase reporter gene (the sites where primer pairs bind are illustrated). These constructs were co-transfected into HEK293 cells alone with an empty vector, KRASDN, KRASG12D or KRASWT expression vector for 48h. Dual luciferase activities were measured. The experiment was repeated three times, each with triplicate samples. Data are expressed as mean {plus minus} SEM (*p < 0.05 Ctrl group vs. KRAS) (left panel).
Data Supplement from EFA6B Antagonizes Breast Cancer
Authors: Zangari Joséphine , Partisani Mariagrazia , Bertucci François , Milanini Julie , Bidaut Ghislain , Berruyer-Pouyet Carole , Finetti Pascal , Long Elodie , Brau Frédéric , Cabaud Olivier , Chetaille Bruno , Birnbaum Daniel , Lopez Marc , Hofman Paul , Franco Michel , Luton Frédéric
Published: March 2023

Supplementary Data. Unedited Full images of immunoblots The figure contains all the unedited immunoblots images presented in the manuscript
SuppFigure3 from Changes in Pyruvate Metabolism Detected by Magnetic Resonance Imaging Are Linked to DNA Damage and Serve as a Sensor of Temozolomide Response in Glioblastoma Cells
Authors: Park Ilwoo , Mukherjee Joydeep , Ito Motokazu , Chaumeil Myriam M. , Jalbert Llewellyn E. , Gaensler Karin , Ronen Sabrina M. , Nelson Sarah J. , Pieper Russell O.
Published: March 2023

SuppFigure3. Stable suppression of PKM2 expression in G55 cells significantly alters intra-cellular concentrations of pyruvate and lactate. (*, p<0.05).
Supplementary Figure Legends, Figures 1 - 6, Table 1 from miRNA-128 Suppresses Prostate Cancer by Inhibiting BMI-1 to Inhibit Tumor-Initiating Cells
Authors: Jin Min , Zhang Tao , Liu Can , Badeaux Mark A. , Liu Bigang , Liu Ruifang , Jeter Collene , Chen Xin , Vlassov Alexander V. , Tang Dean G.
Published: March 2023

PDF file - 226KB, Figure S1. Schematic diagram of the genomic locus of miR-128 (Homo sapiens-miR-128). Figure S2. miR-128 mRNA was down-regulated in human PCa cell lines.Figure S3. Validation of transfection efficiencies and tumor suppression by miR-128. Figure S4. Characterizations of the miR-128 sensor. Figure S5. miR-128 'decoy' promoted clonal expansion and sphere-forming capacity in PC3 and Du145 cells. Figure S6. BMI-1 effects on proliferation of PCa cells as measured by MTT assays. Supplementary Table S1. Primers used in qPCR analysis miR-128 target quantification, BMI-1 and NANOG 3'-UTR cloning, and sequencing.
Supplemental Figure Legends and Figures from Holo-Retinol–Binding Protein and Its Receptor STRA6 Drive Oncogenic Transformation
Authors: Berry Daniel C. , Levi Liraz , Noy Noa
Published: March 2023

Supplemental Figure legends and Figures Fig. S1: Levels of STRA6 and RBP in breast cancers Fig. S2: Effects of decreased STRA6 expression on oncogenic properties. Fig. S3: Immunoblots demonstrating variable RBP expression levels and effects on "wound healing". Fig. S4: Effects of decreased expression of RBP on oncogene expression.
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Supplementary Figure S2. c-Myc does not localize to spindle poles in SK-BR-3, HeLa and U251MG cells. These cell lines were treated with or without MG-132 for 5h. NuMA is green, c-MYC is red, and DAPI (DNA) is blue. Scale bars indicate 10 μm.
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Supplementary Figure S3. Phospho-T58-MYCN accumulates to spindle poles in SK-N-DZ cells. Representative images of phospho-T58-MYCN but not phospho-S62-MYCN accumulation to spindle poles during mitosis in SK-N-DZ cells. MYCN is red, phospho-T58-MYCN or phospho-S62-MYCN is green, and DAPI (DNA) is blue. Arrows show spindle poles. Scale bars indicate 10 μm.
Supplementary Figure 5 from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling
Authors: Lapeire Lore , Hendrix An , Lambein Kathleen , Van Bockstal Mieke , Braems Geert , Van Den Broecke Rudy , Limame Ridha , Mestdagh Pieter , Vandesompele Jo , Vanhove Christian , Maynard Dawn , Lehuédé Camille , Muller Catherine , Valet Philippe , Gespach Christian P. , Bracke Marc , Cocquyt Veronique , Denys Hannelore , De Wever Olivier
Published: March 2023

Western blot analysis of Y705 and S727 pSTAT3, STAT3, (p)Akt, pS6K, (p)Erk1/2 in MCF-7 cells treated for 48h with rhOSM (1ng/ml) and an Akt-inhibitor or Mek-inhibitor at the indicated concentrations.
Data Supplement from AXL Mediates Resistance to Cetuximab Therapy
Authors: Brand Toni M. , Iida Mari , Stein Andrew P. , Corrigan Kelsey L. , Braverman Cara M. , Luthar Neha , Toulany Mahmoud , Gill Parkash S. , Salgia Ravi , Kimple Randall J. , Wheeler Deric L.
Published: March 2023

Supplemental Table S1. Clinical characteristics of patients prior to surgery and PDX establishment pertaining to data presented in Figure 6.
Supplementary Fig. 6 from Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis
Authors: Menard Julien A. , Christianson Helena C. , Kucharzewska Paulina , Bourseau-Guilmain Erika , Svensson Katrin J. , Lindqvist Eva , Chandran Vineesh Indira , Kjellén Lena , Welinder Charlotte , Bengzon Johan , Johansson Maria C. , Belting Mattias
Published: March 2023

Figure S6. Hypoxia induced ERK/MAPK signaling activation by lipoproteins. A, Cell signaling activation by lipoproteins. B and C, Prolonged lipoprotein-mediated ERK1/2 activation in hypoxia.
Supplementary Figure Legends from Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts
Authors: Ambrogio Chiara , Carmona Francisco J. , Vidal August , Falcone Mattia , Nieto Patricia , Romero Octavio A. , Puertas Sara , Vizoso Miguel , Nadal Ernest , Poggio Teresa , Sánchez-Céspedes Montserrat , Esteller Manel , Mulero Francisca , Voena Claudia , Chiarle Roberto , Barbacid Mariano , Santamaría David , Villanueva Alberto
Published: March 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S4.
Supplemental Figures S1-S3 from Long-Chain Fatty Acid Analogues Suppress Breast Tumorigenesis and Progression
Authors: Gluschnaider Udi , Hertz Rachel , Ohayon Sarit , Smeir Elia , Smets Martha , Pikarsky Eli , Bar-Tana Jacob
Published: March 2023

Supplemental Figures S1-S3. c-Src/STAT3 crosstalk of Met-1 cells (S1); c-Src/STAT3 crosstalk of HCC1954 cells (S2); MEDICA amplifies radiation-suppressed clonogenity of HCC1954 cells (S3).
Supplementary Figure S1 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Figure S1. Microarray gene expression across histological subtypes of endometrial cancers.
Supplementary Figure 1 from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: March 2023

PDF file - 126KB, Supplemental Figure 1. The combination of ABT-737 and etoposide is poorly tolerated in mice bearing SCLC PDXs.
Supplemental Table S3 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

KMT1E DNA binding sequences identified by ChIP-Seq.
Supplemental Figure S7 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

KMT1E modulates ANXA2 expression to suppress cancer cell invasion in lung cancer cells.
Supplementary Figure 2 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 54KB, Supplementary Figure S2: GPER mediates the up-regulation of VEGF protein expression by E2 and G-1 in CAFs.
Supplementary Figure 1 from Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
Authors: Cekic Caglar , Day Yuan-Ji , Sag Duygu , Linden Joel
Published: March 2023

Supplementary Figure 1. Selective expression of Cre protein and deletion of A2AR mRNA from granulocytes derived from LysMCre-AdorA2Af/f mice.
Supplementary Figure 1 from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

Testing the efficacy of combination therapy using small molecules to reduce Pten null leukemia burden and LICs in vivo.
Supplementary Figure S2 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: March 2023

Supplementary Figure S2. mRNA levels of ATP6V0C after knockdown.
Supplementary Movie 1 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: March 2023

Supplementary Movie 1. Intermediate computed images: z-projection of mCherry fluorescence images (left), in-focus bright field images (center), final binarized images (right). Time is indicated at the top left. Time origin was set at the end of the centrifugation step.
Supplemental Movie 2 from Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer
Authors: Gül Nuray , van Egmond Marjolein
Published: March 2023

Fluorescent images from live cell imaging experiment demonstrated uptake of blue labeled chronic lymphocytic leukemia (CLL) cells by red labeled human macrophages in the presence of the anti-CD20 mAb rituximab. Time is indicated in minutes. Scale bar = 20 ÃŽÂ¼m.
Supplemental Movie 1 from Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer
Authors: Gül Nuray , van Egmond Marjolein
Published: March 2023

Overlay of bright field and fluorescent images from live cell imaging experiment demonstrated uptake of blue labeled chronic lymphocytic leukemia (CLL) cells by red labeled human macrophages in the presence of the anti-CD20 mAb rituximab. Time is indicated in minutes. Scale bar = 20 ÃŽÂ¼m.
Supplementary Figure 6 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

Suppression of ÃŽÂ²III-tubulin increases cell adhesion and decreases cell migration in NSCLC cells.
Supplementary Table S2 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Table S2. Mean target coverage for each sample sequence is listed.
Supplementary Figure S1 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Figure S1. Mutational spectra of xenograft models and metastatic derivatives.
Supplemental Figures and Tables Legend from Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
Authors: Wettersten Hiromi I. , Hakimi A. Ari , Morin Dexter , Bianchi Cristina , Johnstone Megan E. , Donohoe Dallas R. , Trott Josephine F. , Aboud Omran Abu , Stirdivant Steven , Neri Bruce , Wolfert Robert , Stewart Benjamin , Perego Roberto , Hsieh James J. , Weiss Robert H.
Published: March 2023

Supplemental Figures Legend
Supplemental Table S1 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Table S1. Selectivity of lead HDAC inhibitors for inhibition of HDAC1-9 activities in vitro.
Supplemental Tables S1-S5 from The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers
Authors: Légaré Stéphanie , Cavallone Luca , Mamo Aline , Chabot Catherine , Sirois Isabelle , Magliocco Anthony , Klimowicz Alexander , Tonin Patricia N. , Buchanan Marguerite , Keilty Dana , Hassan Saima , Laperrière David , Mader Sylvie , Aleynikova Olga , Basik Mark
Published: March 2023

Clinical data (S1); Expression levels of SPEN and PGR as evaluated with DNA microarrays (S2); IC50 values of SPEN-overexpressing T47D clones, SPEN-silenced MCF-7 clones and their respective controls (S3); Loss of heterozysity assessment using polymorphic microsatellite repeat markers (S4); Primers sequence for the sequencing of SPEN (S5).
Supplementary Figures S1-S5 from ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy
Authors: Messai Yosra , Noman Muhammad Zaeem , Hasmim Meriem , Janji Bassam , Tittarelli Andrés , Boutet Marie , Baud Véronique , Viry Elodie , Billot Katy , Nanbakhsh Arash , Ben Safta Thouraya , Richon Catherine , Ferlicot Sophie , Donnadieu Emmanuel , Couve Sophie , Gardie Betty , Orlanducci Florence , Albiges Laurence , Thiery Jerome , Olive Daniel , Escudier Bernard , Chouaib Salem
Published: March 2023

Supplementary Figures S1-S5. Figure S1. Differential susceptibility of 786-0, PRC3, and WT7 cell lines to NK-mediated lysis. Figure S2. Role of ANGPTL4 and ADM in RCC cell susceptibility to NK-mediated lysis. Figure S3. VHL and NK ligand expression in RCC cells. Figure S4. Silencing of HIF-2α and NK ligand expression in 786-0 cells. Figure S5. VHL status, targeting of HIF-2α or silencing of ITPR1 does not regulate autophagy in 786-0 cells.
Supplementary Table 2 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Full Table for the CASC15-S Cox Statistical Model.
Supplementary Figure 5 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Additional expression data for CASC15 isoforms in neuroblastoma cell lines and patients.
Supplementary Figure 3 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Results of Sanger sequencing from 5' and 3'-RACE products of CASC15-S.
Supplementary Figure 1 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Evidence supporting multiple lncRNA transcript isoforms mapping to chromosome 6p22.3.
Supplementary Table 2 from PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia
Authors: McElwee John L. , Mohanan Sunish , Horibata Sachi , Sams Kelly L. , Anguish Lynne J. , McLean Dalton , Cvitaš Iva , Wakshlag Joseph J. , Coonrod Scott A.
Published: March 2023

Supplementary Table 2: Primers for mouse quantitative RT-PCR (SYBR)
Supplementary Figure 1 from PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia
Authors: McElwee John L. , Mohanan Sunish , Horibata Sachi , Sams Kelly L. , Anguish Lynne J. , McLean Dalton , Cvitaš Iva , Wakshlag Joseph J. , Coonrod Scott A.
Published: March 2023

Supplementary Figure 1: MMTV-FLAG-PAD2 expression in the mammary gland
Supplementary Figure 4 from Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity
Authors: Browne Ashley , Tookman Laura A. , Ingemarsdotter Carin K. , Bouwman Russell D. , Pirlo Katrina , Wang Yaohe , McNeish Iain A. , Lockley Michelle
Published: March 2023

Hexon immunohistochemistry in spleens of WT and b3-/- female mice 3hrs post IP injection with dl922-947 (10^10 particles). Hexon expression was scored by a pathologist who was blind to the experimental groups. (n = 6 mice per genotype)
Supplementary Figures 1 - 5 from Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
Authors: Kantara Carla , O'Connell Malaney , Sarkar Shubhashish , Moya Stephanie , Ullrich Robert , Singh Pomila
Published: March 2023

PDF file - 2102KB, Colon cancer cells positive for DCLK1, co-express CD44, while Lgr5+ve cells do not (S1). Localization of cells expressing DCLK1/Lgr5/CD44 within spheroidal growths (S2). Effect of curcumin on relative expression of indicated proteins in HCT-116 cells, growing as either 2D monolayers, or 3D spheroids or xenografts in athymic nude mice (S3). Curcumin induces autophagy in HCT-116 cells in culture (S4). Effect of curcumin�DCLK1-siRNA on levels of LC3-I/II and PCNA staining and on stem cell populations in HCT-116 xenografts (S5).
Supplementary Fig 2 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

Expression of the p.M600T, p.Y568C and p.C604W MPS1 mutant constructs in DLD1 Flp-In TRex cells recues the spindle assembly checkpoint defect following AZ3146 treatment.
Supplementary Figure Legend from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Authors: Ko Chun-Jung , Huang Cheng-Chung , Lin Hsin-Ying , Juan Chun-Pai , Lan Shao-Wei , Shyu Hsin-Yi , Wu Shang-Ru , Hsiao Pei-Wen , Huang Hsiang-Po , Shun Chia-Tung , Lee Ming-Shyue
Published: March 2023

Supplementary Figure Legend. Legend for Supplementary Figures S1-S5.
Supplementary Figure S7 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: March 2023

Supplementary Figure S7. Foretinib reduces tumor growth in SHH medulloblastoma xenografts
Supplemental Figure S1 from Therapeutically Targetable ALK Mutations in Leukemia
Authors: Maxson Julia E. , Davare Monika A. , Luty Samuel B. , Eide Christopher A. , Chang Bill H. , Loriaux Marc M. , Tognon Cristina E. , Bottomly Daniel , Wilmot Beth , McWeeney Shannon K. , Druker Brian J. , Tyner Jeffrey W.
Published: March 2023

ALK is expressed in the B-ALL sample with the ALK A348D mutation.
supplementary figure 3 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: March 2023

supplementary figure 3: immunohistochemical analysis of CXCL-12 expression in AML bone marrow.
Supplementary Table S7 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: March 2023

Pharmacokinetic parameters of MBP vemurafenib in huPXR/huCAR/huCYP3A4/3A7 mice.
Supplementary Figure 3 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: March 2023

Supplementary Figure 3: Osteocyte conditioned media promotes viability of breast and lung cancer cell lines. OCy CM was incubated with breast (MDA-MB-231 and MCF7) and lung (A549 and H441) tumor cells for 24 hours before determination of viability using resazurin. Student's two-tailed unpaired t-test was used to assess statistical differences; p<0.05.
Supplemental Methods and References from Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer
Authors: Tesfay Lia , Clausen Kathryn A. , Kim Jin Woo , Hegde Poornima , Wang Xiaohong , Miller Lance D. , Deng Zhiyong , Blanchette Nicole , Arvedson Tara , Miranti Cindy K. , Babitt Jodie L. , Lin Herbert Y. , Peehl Donna M. , Torti Frank M. , Torti Suzy V.
Published: March 2023

Supplemental Methods and References. Description of additional methods and procedures used in the study. Also includes Supplemental References.
Supplemental Figures 1 - 5, Figure Legends and Methods from Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma
Authors: Maiso Patricia , Huynh Daisy , Moschetta Michele , Sacco Antonio , Aljawai Yosra , Mishima Yuji , Asara John M. , Roccaro Aldo M. , Kimmelman Alec C. , Ghobrial Irene M.
Published: March 2023

Supplemental Figure 1. Hypoxia-induced drug resistance on MM cells. Supplemental Figure 2. HK2, PFKFB3, PFKFB4 and LDHA expression in MM cell lines. Supplemental Figure 3. (A-B) HIF1A expression in MM1S-shHIF1A. (C) HIF2A expression in MM1S-shHIF2A. (D) Stable knockdown of HIF1A restores the effect of melphalan under hypoxic conditions. (E) HIF1A expression in MM1S-shHIF1A. Supplemental Figure 4. (A-B) HK2 and LDHA expression in MM1S-shHK2, MM1S-shLDHA. (C) Relative mRNA levels of HK2 and LDHA in CD138 + cells 3 from normal donors bone marrow, MGUS, Smoldering myeloma and newly diagnosed myeloma (GSE6477). (D) Stable knockdown of LDHA partially restore the effect of melphalan under hypoxic conditions. (E) PDK1 expression in MM1S-PDK1 expressing cells. (F) Stable overexpression of PDK1 induces resistance to bortezomib in MM1S cells. Supplemental Figure 5. LDHA and HIF1A expression in ANBL6-BRshLDHA, MM1S-HIF1A OE and in MM1S-LDHA OE cells.
Supplementary Figure 2 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Production of TNF-a by Cetux-CAR and Nimo-CAR+ T cells in response to different densities of EGFR
Supplementary Figure S2: MSMS identification of lipids and polar compounds mentioned in the manuscript from Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Authors: Southam Andrew D. , Khanim Farhat L. , Hayden Rachel E. , Constantinou Julia K. , Koczula Katarzyna M. , Michell Robert H. , Viant Mark R. , Drayson Mark T. , Bunce Chris M.
Published: March 2023

MSMS identification of phospholipids and glycerol 3-phosphate using collision induced dissociation (CID) fragmentation.
Supplemental Figures 1-6 from Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma
Authors: Yamada Tadaaki , Amann Joseph M. , Fukuda Koji , Takeuchi Shinji , Fujita Naoya , Uehara Hisanori , Iwakiri Shotaro , Itoi Kazumi , Shilo Konstantin , Yano Seiji , Carbone David P.
Published: March 2023

Supplemental Figures 1-6. Sup. Figure 1: The effect of knockdown for Aki1 and EGFR on mesothelioma cells. Sup. Figure 2: The knockdown of Aki1 and CREB1 in mesothelioma cells. Sup. Figure 3: The knockdown of Aki1 or CREB1 by siRNA on the cell viability of mesothelial cells. Sup. Figure 4: Schema showing the role of Aki1 in DMM cells. Sup. Figure 5: p-CREB and Aki1 expression in DMM vary in intensity. Sup. Figure 6: Expression of pCREB and Aki1 in DMM histological subtypes.
Supplementary Table S1 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Supplementary Table S1. SAM analyses of lung mets versus primary tumors
Supplementary Figures S1-S6 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Supplementary Figures S1-S6. Supplemental Figure S1. The Differentiation scores (Dscore) of primary tumors and lung met-derived tumors. Supplemental Figure S2. miRNA expression in breast tumors. Supplemental Figure S3. Increased miR-138 expression in metastases versus paired primary tumors. Supplemental Figure S4. FISH analysis of miR-138 gene copy number Supplemental Figure S5. Ability of the miR-138 activity signature to predict breast cancer-specific survival. Supplemental Figure S6. Downstream targets of miR-138.
Supplementary figure 3 from Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Authors: Mansour Nassir M. , Bernal Giovanna M. , Wu Longtao , Crawley Clayton D. , Cahill Kirk E. , Voce David J. , Balyasnikova Irina V. , Zhang Wei , Spretz Ruben , Nunez Luis , Larsen Gustavo F. , Weichselbaum Ralph R. , Yamini Bakhtiar
Published: March 2023

Supplementary figure 3. A, annexin V binding in U251 cells treated with vehicle or temozolomide (TMZ, 100 μM) following transfection with the indicated siRNA. B, clonogenic assay in A172 cells transfected with the indicated siRNA following treatment with the indicated concentration of TMZ. C, clonogenic assay in U251 cells transfected with si-RNA and treated with TMZ. *, P < 0.05.
Suppl Table S4 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Suppl Table S4. Predicted transcription factor binding sites
Supplementary Figure S2 from JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms
Authors: Schönberg Kathrin , Rudolph Janna , Vonnahme Maria , Parampalli Yajnanarayana Sowmya , Cornez Isabelle , Hejazi Maryam , Manser Angela R. , Uhrberg Markus , Verbeek Walter , Koschmieder Steffen , Brümmendorf Tim H. , Brossart Peter , Heine Annkristin , Wolf Dominik
Published: March 2023

Supplementary Figure S2. Phosphorylation levels of JAK1 and JAK3 were not affected by ruxolitinib.
Supplementary Figure Legend from JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms
Authors: Schönberg Kathrin , Rudolph Janna , Vonnahme Maria , Parampalli Yajnanarayana Sowmya , Cornez Isabelle , Hejazi Maryam , Manser Angela R. , Uhrberg Markus , Verbeek Walter , Koschmieder Steffen , Brümmendorf Tim H. , Brossart Peter , Heine Annkristin , Wolf Dominik
Published: March 2023

Supplementary Figure Legend
Supplementary Figure S2 from Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells
Authors: Hebeisen Michael , Schmidt Julien , Guillaume Philippe , Baumgaertner Petra , Speiser Daniel E. , Luescher Immanuel , Rufer Nathalie
Published: March 2023

Supplementary Figure S2. Relationship between monomeric off-rates by reversible NTAmers and monomeric off-rates and affinity by SPR.
Supplementary Table 1, Figures 1 - 4 from In Vivo Tomographic Imaging of Deep-Seated Cancer Using Fluorescence Lifetime Contrast
Authors: Rice William L. , Shcherbakova Daria M. , Verkhusha Vladislav V. , Kumar Anand T.N.
Published: March 2023

Supplementary table 1: Table of tissue optical properties used in Monte Carlo simulations. Food autofluorescence: Food autofluorescence can be reduced in the fluorescence images either through specially formulated diet, or using lifetime contrast. Supplementary Figure 1: Fluorescence lifetime contrast between iRFP labelled cancer cells and food autofluorescence. Supplementary Figure 2: Sensitivity for detection of iRFP720 labelled cells subcutaneously placed in a live mouse. Supplementary Figure 3: Lifetime analysis of ex vivo cryosections reveal that iRFP labelled cancer cells i.v. injected in live mice are localized to the lungs. Supplementary Figure 4: CW Fluorescence reflectance images of ex vivo cryosections provide limited contrast for detecting differential extent of experimental metastasis formation in three mice.
Supplementary Figure S1 from Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a
Authors: Liu Ming , Huang Feifei , Zhang Dan , Ju Junyi , Wu Xiao-Bin , Wang Ying , Wang Yadong , Wu Yupeng , Nie Min , Li Zhuchen , Ma Chi , Chen Xi , Zhou Jin-Yong , Tan Renxiang , Yang Bo-Lin , Zen Ke , Zhang Chen-Yu , Chen Yu-Gen , Zhao Quan
Published: March 2023

Analysis of the effect of miR-30a on HP1γ protein and mRNA.
Supplementary Figure 3 from Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate
Authors: Schwartz-Roberts Jessica L. , Cook Katherine L. , Chen Chun , Shajahan-Haq Ayesha N. , Axelrod Margaret , Wärri Anni , Riggins Rebecca B. , Jin Lu , Haddad Bassem R. , Kallakury Bhaskar V. , Baumann William T. , Clarke Robert
Published: March 2023

Silencing ATG7 and BECN1 induces IRF1 expression independently of ROS.
Supplementary Figure S7 from CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity
Authors: Boyle Samantha E. , Fedele Clare G. , Corbin Vincent , Wybacz Elisha , Szeto Pacman , Lewin Jeremy , Young Richard J. , Wong Annie , Fuller Robert , Spillane John , Speakman David , Donahoe Simon , Pohl Miklos , Gyorki David , Henderson Michael A. , Johnstone Ricky W. , Papenfuss Anthony T. , Shackleton Mark
Published: March 2023

Genomic copy number differences among sibling PDX melanomas.
Video 5 from Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes
Authors: Robertson-Tessi Mark , Gillies Robert J. , Gatenby Robert A. , Anderson Alexander R.A.
Published: March 2023

Video 5: Varying vascular density. Simulation of growth with varying vascular density
Supplemental Figure S4 from A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors
Authors: Moores Sheri L. , Chiu Mark L. , Bushey Barbara S. , Chevalier Kristen , Luistro Leopoldo , Dorn Keri , Brezski Randall J. , Haytko Peter , Kelly Thomas , Wu Sheng-Jiun , Martin Pauline L. , Neijssen Joost , Parren Paul W.H.I. , Schuurman Janine , Attar Ricardo M. , Laquerre Sylvie , Lorenzi Matthew V. , Anderson G. Mark
Published: March 2023

JNJ-61186372 recovered in serum from cynomolgus monkeys treated with JNJ-61186372 inhibited ligand-induced phosphorylation of both EGFR and cMet in a lung cancer cell line.
Supplementary Figure S3 from Acute Tissue Injury Activates Satellite Cells and Promotes Sarcoma Formation via the HGF/c-MET Signaling Pathway
Authors: Van Mater David , Añó Leonor , Blum Jordan M. , Webster Micah T. , Huang WeiQiao , Williams Nerissa , Ma Yan , Cardona Diana M. , Fan Chen-Ming , Kirsch David G.
Published: March 2023

Supplementary Figure S3. DMSO mediated injury after 4OHT injection requires c-Met for sarcoma promotion.
Supplementary Figure 5 from HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival
Authors: Mitobe Yuichi , Yasunaga Jun-ichirou , Furuta Rie , Matsuoka Masao
Published: March 2023

HBZ RNA activates survivin promoter in ILF3, p54nrb, and TLS-independent manner
Supplementary Figure 4 from HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival
Authors: Mitobe Yuichi , Yasunaga Jun-ichirou , Furuta Rie , Matsuoka Masao
Published: March 2023

HBZ RNA activates the survivin promoter in the absence of cell cycle dependent element (CDE)/cell cycle homology region (CHE), p53, or Sp-1 binding site
Supplementary Figure legends from TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases
Authors: Ham Boram , Wang Ni , D'Costa Zarina , Fernandez Maria Celia , Bourdeau France , Auguste Patrick , Illemann Martin , Eefsen Rikke Loevendahl , Høyer-Hansen Gunilla , Vainer Ben , Evrard Maximilien , Gao Zu-Hua , Brodt Pnina
Published: March 2023

Legends for 8 supplementary figures
Figure S5 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: March 2023

Supplementary Figure 5
Suppl. Movie 2 from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence
Published: March 2023

MDA-MB-231 Dendra2 tumors followed by intravital microscopy after 8 days of vehicle treatment
Supplementary Figure 1 from The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(—)
Authors: Tsuchihashi Kenji , Okazaki Shogo , Ohmura Mitsuyo , Ishikawa Miyuki , Sampetrean Oltea , Onishi Nobuyuki , Wakimoto Hiroaki , Yoshikawa Momoko , Seishima Ryo , Iwasaki Yoshimi , Morikawa Takayuki , Abe Shinya , Takao Ayumi , Shimizu Misato , Masuko Takashi , Nagane Motoo , Furnari Frank B. , Akiyama Tetsu , Suematsu Makoto , Baba Eishi , Akashi Koichi , Saya Hideyuki , Nagano Osamu
Published: March 2023

EGFR interacts with the central portion of xCT and thereby promotes surface expression of xCT.
supplemental figure legends from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: March 2023

supplemental figure legends
Supplementary Video S8 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: March 2023

Supplementary Video S8. Physical appearance of mice treated with MN-anti-miR10b/MN-scr-miR and doxorubicin.
Supplementary Figure 2 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: March 2023

Supplementary Figure 2. (A) Heatmap representing IL-6/STAT3 pathway genes expression status. (B-C) Mass spectrometric quantification of IL-6 and STAT3 in lung cancer cell lines. (D) Siltuximab and Tocilizumab decreased STAT3 activation in NSCLC cell lines.
Supplementary Methods and References from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.