bluuebunny/crossref_metadata_2025 huggingface dataset:
Occupants’ Decision-Making of Their Energy Behaviours in Office Environments: A Case of New Zealand
Authors: Weerasinghe Achini Shanika , Rasheed Eziaku Onyeizu , Rotimi James Olabode Bamidele
Published: January 2023

Understanding how occupants behave and interact with building systems is vital to energy efficiency in buildings. The building occupants’ behaviours are complex and influenced by diverse factors. A deep understanding of the underlying environmental, contextual, social, and psychological factors is the first step of many in establishing the relationship between the indoor environment and occupants’ behaviours. The current study investigates the influence of occupants’ perceived indoor environmental comfort, the availability of control, and the social-psychological impacts on occupant behaviours in a New Zealand context. The data were collected through online surveys, and 99 office occupants responded. A machine learning technique was applied to identify the critical factors influencing the decision-making of occupant behaviours. Of the occupant behaviours considered in the study, adjusting windows, doors, shades and blinds, and drinking beverages were mostly practised (>70%) while adjusting lighting, personal fans, thermostats/heaters, and computers (40–70%) was moderately practised by occupants. The availability of specific user controls was the main predictor of most occupant behaviours, followed by social-psychological factors such as actual knowledge, perceived knowledge, behavioural interventions, subjective norms, organisational support, personal norms, attitudes, and perceived behavioural control. The indoor environmental parameters such as indoor temperature, indoor air quality, natural light, and inside noise were highlighted as most influential in decision-making for occupant behaviours. Additionally, the demographic factors: gender, work duration, days at work, and permanence/temporariness of workspace, were also impactful. Knowing the complexity of occupants’ decision-making with respect to their behaviours helps building managers use this sensitive information to enhance building energy performance and enable more energy feedback to the occupants to raise their awareness. Such information is helpful for creating an intelligent environmental control system loop with eco-feedback and establishing occupant-centric buildings or features.
An Artwork Rental System Based on Blockchain Technology
Authors: Huang Der-Chen , Liu Ling-Chun , Deng Yong-Yuan , Chen Chin-Ling
Published: January 2023

In recent years, due to the slowdown of the global economy and the instability of the stock market and real estate market, the art market has gradually become the third-largest investment market after the former two. As more and more funds flow into the art market, the two seemingly unrelated industries, art, and finance have increasingly close cooperation due to the growing prosperity of the art market. As a very important part of the process of art financialization, the development of art banks has also received extensive attention from all walks of life. In addition, blockchain, as a technology to jointly maintain reliable databases through trustlessness and decentralization, has grown rapidly in recent years, and is gradually applied in various fields. The advantages of blockchain technology are decentralization, anonymity, immutability, and traceability of stored information. The proposed scheme applies the characteristics of blockchain technology to Art Bank’s art rental system, and will have the following advantages: the use of Hyperledger technology, various art banks being merged into an alliance, and information among alliance members being shared, which is convenient for tenants to comprehensively query a single item. Using blockchain technology, in an environment where there is no central authority, under the premise of preventing the tampering of artwork-related information, ensures that the detailed information of the artwork is shared. Traditional leasing agreements can be compiled into smart contract leasing contracts to automatically run and manipulate data. The proposed protocol satisfies the following security requirements: identities’ mutual authentication, non-repudiation between every two parties, and other major security requirements based on blockchain. When a dispute arises, our proposed scheme also has an arbitration mechanism to clarify responsibilities.
Spectral Solutions of Even-Order BVPs Based on New Operational Matrix of Derivatives of Generalized Jacobi Polynomials
Authors: Abd-Elhameed Waleed Mohamed , Badah Badah Mohamed , Amin Amr Kamel , Alsuyuti Muhammad Mahmoud
Published: January 2023

The primary focus of this article is on applying specific generalized Jacobi polynomials (GJPs) as basis functions to obtain the solution of linear and non-linear even-order two-point BVPs. These GJPs are orthogonal polynomials that are expressed as Legendre polynomial combinations. The linear even-order BVPs are treated using the Petrov–Galerkin method. In addition, a formula for the first-order derivative of these polynomials is expressed in terms of their original ones. This relation is the key to constructing an operational matrix of the GJPs that can be used to treat the non-linear two-point BVPs. In fact, a numerical approach is proposed using this operational matrix of derivatives to convert the non-linear differential equations into effectively solvable non-linear systems of equations. The convergence of the proposed generalized Jacobi expansion is investigated. To show the precision and viability of our suggested algorithms, some examples are given.
Assessment of Cognitive Fatigue from Gait Cycle Analysis
Authors: Pavel Hamza Reza , Karim Enamul , Jaiswal Ashish , Acharya Sneh , Nale Gaurav , Theofanidis Michail , Makedon Fillia
Published: January 2023

Cognitive Fatigue (CF) is the decline in cognitive abilities due to prolonged exposure to mentally demanding tasks. In this paper, we used gait cycle analysis, a biometric method related to human locomotion to identify cognitive fatigue in individuals. The proposed system in this paper takes two asynchronous videos of the gait of individuals to classify if they are cognitively fatigued or not. We leverage the pose estimation library OpenPose, to extract the body keypoints from the frames in the videos. To capture the spatial and temporal information of the gait cycle, a CNN-based model is used in the system to extract the embedded features which are then used to classify the cognitive fatigue level of individuals. To train and test the model, a gait dataset is built from 21 participants by collecting walking data before and after inducing cognitive fatigue using clinically used games. The proposed model can classify cognitive fatigue from the gait data of an individual with an accuracy of 81%.
The Panoramic View of Ecuadorian Soil Nutrients (Deficit/Toxicity) from Different Climatic Regions and Their Possible Influence on the Metabolism of Important Crops
Authors: Mihai Raluca A. , Melo Heras Erly J. , Terán Maza Vanessa A. , Espinoza Caiza Iván A. , Pinto Valdiviezo Eliza A. , Catana Rodica D.
Published: January 2023

Soil nutrients influence all stages (reproduction, growth, and development) of a plant species’ life, and it is known that the deficit and/or toxicity of one or more nutrients has negative effects on the production of crops of commercial interest. Ecuador represents one of the “mega-diverse” countries in the world, with an agricultural sector of great importance, due to its contribution to the country’s economy. This review provides a panoramic view of soil nutrients from different climatic regions of Ecuador and revises the importance of knowledge about the possible influence of nutrients from the soil on the plant metabolism able to influence the crop resistance against pathogens or to enrich the biological characteristics of these crops.
Bacteriophages as Biotechnological Tools
Authors: Elois Mariana Alves , Silva Raphael da , Pilati Giulia Von Tönnemann , Rodríguez-Lázaro David , Fongaro Gislaine
Published: January 2023

Bacteriophages are ubiquitous organisms that can be specific to one or multiple strains of hosts, in addition to being the most abundant entities on the planet. It is estimated that they exceed ten times the total number of bacteria. They are classified as temperate, which means that phages can integrate their genome into the host genome, originating a prophage that replicates with the host cell and may confer immunity against infection by the same type of phage; and lytics, those with greater biotechnological interest and are viruses that lyse the host cell at the end of its reproductive cycle. When lysogenic, they are capable of disseminating bacterial antibiotic resistance genes through horizontal gene transfer. When professionally lytic—that is, obligately lytic and not recently descended from a temperate ancestor—they become allies in bacterial control in ecological imbalance scenarios; these viruses have a biofilm-reducing capacity. Phage therapy has also been advocated by the scientific community, given the uniqueness of issues related to the control of microorganisms and biofilm production when compared to other commonly used techniques. The advantages of using bacteriophages appear as a viable and promising alternative. This review will provide updates on the landscape of phage applications for the biocontrol of pathogens in industrial settings and healthcare.
Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2
Authors: Sun Haoran , Chan Jasper Fuk-Woo , Yuan Shuofeng
Published: January 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic that has caused disastrous effects on the society and human health globally. SARS-CoV-2 is a sarbecovirus in the Coronaviridae family with a positive-sense single-stranded RNA genome. It mainly replicates in the cytoplasm and viral components including RNAs and proteins can be sensed by pattern recognition receptors including toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and NOD-like receptors (NLRs) that regulate the host innate and adaptive immune responses. On the other hand, the SARS-CoV-2 genome encodes multiple proteins that can antagonize the host immune response to facilitate viral replication. In this review, we discuss the current knowledge on host sensors and viral countermeasures against host innate immune response to provide insights on virus–host interactions and novel approaches to modulate host inflammation and antiviral responses.
Rapid System to Detect Variants of SARS-CoV-2 in Nasopharyngeal Swabs
Authors: Favaro Marco , Zampini Paola , Pistoia Enrico , Gaziano Roberta , Grelli Sandro , Fontana Carla
Published: January 2023

Currently, the reference method for identifying the presence of variants of SARS-CoV-2 is whole genome sequencing. Although it is less expensive than in the past, it is still time-consuming, and interpreting the results is difficult, requiring staff with specific skills who are not always available in diagnostic laboratories. The test presented in this study aimed to detect, using traditional real-time PCR, the presence of the main variants described for the spike protein of the SARS-CoV-2 genome. The primers and probes were designed to detect the main deletions that characterize the different variants. The amplification targets were deletions in the S gene: 25–27, 69–70, 241–243, and 157–158. In the ORF1a gene, the deletion 3675–3677 was chosen. Some of these mutations can be considered specific variants, while others can be identified by the simultaneous presence of one or more deletions. We avoided using point mutations in order to improve the speed of the test. Our test can help clinical and medical microbiologists quickly recognize the presence of variants in biological samples (particularly nasopharyngeal swabs). The test can also be used to identify variants of the virus that could potentially be more diffusive as well as not responsive to the vaccine.
Ocular Symptoms Associated with COVID-19 Are Correlated with the Expression Profile of Mouse SARS-CoV-2 Binding Sites
Authors: Brechbühl Julien , Ferreira Flavio , Lopes Ana Catarina , Corset Emilly , Gilliand Noah , Broillet Marie-Christine
Published: January 2023

The COVID-19 pandemic has engendered significant scientific efforts in the understanding of its infectious agent SARS-CoV-2 and of its associated symptoms. A peculiar characteristic of this virus lies in its ability to challenge our senses, as its infection can lead to anosmia and ageusia. While ocular symptoms, such as conjunctivitis, optic neuritis or dry eyes, are also reported after viral infection, they have lower frequencies and severities, and their functional development is still elusive. Here, using combined technical approaches based on histological and gene profiling methods, we characterized the expression of SARS-CoV-2 binding sites (Ace2/Tmprss2) in the mouse eye. We found that ACE2 was ectopically expressed in subtissular ocular regions, such as in the optic nerve and in the Harderian/intraorbital lacrimal glands. Moreover, we observed an important variation of Ace2/Tmprss2 expression that is not only dependent on the age and sex of the animal, but also highly heterogenous between individuals. Our results thus give new insight into the expression of SARS-CoV-2 binding sites in the mouse eye and propose an interpretation of the human ocular-associated symptoms linked to SARS-CoV-2.
Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures
Authors: Xiao Hao , Zhou Junquan , Yang Fan , Liu Zheng , Song Jingdong , Chen Wenyuan , Liu Hongrong , Cheng Lingpeng
Published: January 2023

The formation of many double-stranded DNA viruses, such as herpesviruses and bacteriophages, begins with the scaffolding-protein-mediated assembly of the procapsid. Subsequently, the procapsid undergoes extensive structural rearrangement and expansion to become the mature capsid. Bacteriophage P22 is an established model system used to study virus maturation. Here, we report the cryo-electron microscopy structures of procapsid, empty procapsid, empty mature capsid, and mature capsid of phage P22 at resolutions of 2.6 Å, 3.9 Å, 2.8 Å, and 3.0 Å, respectively. The structure of the procapsid allowed us to build an accurate model of the coat protein gp5 and the C-terminal region of the scaffolding protein gp8. In addition, interactions among the gp5 subunits responsible for procapsid assembly and stabilization were identified. Two C-terminal α-helices of gp8 were observed to interact with the coat protein in the procapsid. The amino acid interactions between gp5 and gp8 in the procapsid were consistent with the results of previous biochemical studies involving mutant proteins. Our structures reveal hydrogen bonds and salt bridges between the gp5 subunits in the procapsid and the conformational changes of the gp5 domains involved in the closure of the local sixfold opening and a thinner capsid shell during capsid maturation.
Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge
Authors: Noyce Ryan S. , Westfall Landon W. , Fogarty Siobhan , Gilbert Karen , Mpanju Onesmo , Stillwell Helen , Esparza José , Daugherty Bruce , Koide Fusataka , Evans David H. , Lederman Seth
Published: January 2023

The ongoing global Monkeypox outbreak that started in the spring of 2022 has reinforced the importance of protecting the population using live virus vaccines based on the vaccinia virus (VACV). Smallpox also remains a biothreat and although some U.S. military personnel are immunized with VACV, safety concerns limit its use in other vulnerable groups. Consequently, there is a need for an effective and safer, single dose, live replicating vaccine against both viruses. One potential approach is to use the horsepox virus (HPXV) as a vaccine. Contemporary VACV shares a common ancestor with HPXV, which from the time of Edward Jenner and through the 19th century, was extensively used to vaccinate against smallpox. However, it is unknown if early HPXV-based vaccines exhibited different safety and efficacy profiles compared to modern VACV. A deeper understanding of HPXV as a vaccine platform may allow the construction of safer and more effective vaccines against the poxvirus family. In a proof-of-concept study, we vaccinated cynomolgus macaques with TNX-801, a recombinant chimeric horsepox virus (rcHPXV), and showed that the vaccine elicited protective immune responses against a lethal challenge with monkeypox virus (MPXV), strain Zaire. The vaccine was well tolerated and protected animals from the development of lesions and severe disease. These encouraging data support the further development of TNX-801.
Sida Golden Mosaic Virus, an Emerging Pathogen of Snap Bean (Phaseolus vulgaris L.) in the Southeastern United States
Authors: Gautam Saurabh , Buck James W. , Dutta Bhabesh , Coolong Timothy , Sanchez Tatiana , Smith Hugh A. , Adkins Scott , Srinivasan Rajagopalbabu
Published: January 2023

Sida golden mosaic virus (SiGMV) was first detected from snap bean (Phaseolus vulgaris L.) in Florida in 2006 and recently in Georgia in 2018. Since 2018, it has caused significant economic losses to snap bean growers in Georgia. This study, using a SiGMV isolate field-collected from prickly sida (Sida spinosa L.), examined the putative host range, vector-mediated transmission, and SiGMV-modulated effects on host–vector interactions. In addition, this study analyzed the phylogenetic relationships of SiGMV with other begomoviruses reported from Sida spp. Host range studies confirmed that SiGMV can infect seasonal crops and perennial weed species such as snap bean, hollyhock (Alcea rosea L.), marsh mallow (Althaea officinalis L.), okra (Abelmoschus esculentus (L.) Moench), country mallow (Sida cordifolia L.), prickly sida (S. spinosa), and tobacco (Nicotiana tabacum L.). The incidence of infection ranged from 70 to 100%. SiGMV-induced symptoms and virus accumulation varied between hosts. The vector, Bemisia tabaci Gennadius, was able to complete its life cycle on all plant species, irrespective of SiGMV infection status. However, SiGMV infection in prickly sida and country mallow positively increased the fitness of whiteflies, whereas SiGMV infection in okra negatively influenced whitefly fitness. Whiteflies efficiently back-transmitted SiGMV from infected prickly sida, hollyhock, marsh mallow, and okra to snap bean, and the incidence of infection ranged from 27 to 80%. Complete DNA-A sequence from this study shared 97% identity with SiGMV sequences reported from Florida and it was determined to be closely related with sida viruses reported from the New World. These results suggest that SiGMV, a New World begomovirus, has a broad host range that would allow its establishment in the farmscapes/landscapes of the southeastern United States and is an emerging threat to snap bean and possibly other crops.
A Renaissance for Oncolytic Adenoviruses?
Authors: Blanchette Paola , Teodoro Jose G.
Published: January 2023

In the 1990s, adenovirus became one of the first virus types to be genetically engineered to selectively destroy cancer cells. In the intervening years, the field of “oncolytic viruses” has slowly progressed and culminated in 2015 with the FDA approval of Talimogene laherparepvec, a genetically engineered herpesvirus, for the treatment of metastatic melanoma. Despite the slower progress in translating oncolytic adenovirus to the clinic, interest in the virus remains strong. Among all the clinical trials currently using viral oncolytic agents, the largest proportion of these are using recombinant adenovirus. Many trials are currently underway to use oncolytic virus in combination with immune checkpoint inhibitors (ICIs), and early results using oncolytic adenovirus in this manner are starting to show promise. Many of the existing strategies to engineer adenoviruses were designed to enhance selective tumor cell replication without much regard to interactions with the immune system. Adenovirus possesses a wide range of viral factors to attenuate both innate anti-viral pathways and immune cell killing. In this review, we summarize the strategies of oncolytic adenoviruses currently in clinical trials, and speculate how the mutational backgrounds of these viruses may impact upon the efficacy of these agents in oncolytic and immunotherapy. Despite decades of research on human adenoviruses, the interactions that these viruses have with the immune system remains one of the most understudied aspects of the virus and needs to be improved to rationally design the next generation of engineered viruses.
Transmissible Gastroenteritis Virus: An Update Review and Perspective
Authors: Chen Yiwu , Zhang Yuanzhu , Wang Xi , Zhou Jian , Ma Lerong , Li Jianing , Yang Lin , Ouyang Hongsheng , Yuan Hongming , Pang Daxin
Published: January 2023

Transmissible gastroenteritis virus (TGEV) is a member of the alphacoronavirus genus, which has caused huge threats and losses to pig husbandry with a 100% mortality in infected piglets. TGEV is observed to be recombining and evolving unstoppably in recent years, with some of these recombinant strains spreading across species, which makes the detection and prevention of TGEV more complex. This paper reviews and discusses the basic biological properties of TGEV, factors affecting virulence, viral receptors, and the latest research advances in TGEV infection-induced apoptosis and autophagy to improve understanding of the current status of TGEV and related research processes. We also highlight a possible risk of TGEV being zoonotic, which could be evidenced by the detection of CCoV-HuPn-2018 in humans.
Simulation of Runoff through Improved Precipitation: The Case of Yamzho Yumco Lake in the Tibetan Plateau
Authors: Tang Handuo , Zhang Fan , Zeng Chen , Wang Li , Zhang Hongbo , Xiang Yuxuan , Yu Zhongbo
Published: January 2023

Alpine lakes on the Tibetan Plateau have significantly changed under a changing climate over past decades. However, the changing patterns of the inflow sources of the lakes, i.e., rainfall and the melt water of snow and glaciers, and their response to climate change remain uncertain because obtaining accurate precipitation and melt water discharge is difficult due to the complex topography, spatial variability, and scarce stations of the alpine area. A distributed hydrological model, J2000, was employed in this study to simulate runoff component variations of the Yamzho Yumco Lake glaciated basin during 1974–2019. Except for observed daily runoff from two tributaries, a High Asia Refined (HAR) high-resolution reanalysis of precipitation data was combined with field precipitation gradient observation and snow cover area validation, all performed simultaneously to reduce the uncertainty of inflow components in the model. Results showed that the average runoff into the lake during 1974–2019 was 5.5 ± 1.4 × 108 m3/10a, whereas rainfall runoff, glacier melt runoff, snowmelt runoff, and baseflow contributed to 54.6%, 10.8%, 1.8%, and 32.7% of total runoff in mean, respectively. Seasonal runoff in spring, summer, autumn, and winter accounted for 6.7%, 60.6%, 23.9% and 8.8% of annual total runoff, respectively. In glacial areas, the reduction in total runoff after removing the precipitation trend was 1.4 times than that of temperature, and in non-glacial areas, the reduction in total runoff after removing the precipitation trend was 1.6 times than the increase in total runoff after removing the temperature trend. The proportion of rainfall runoff increased at a rate of 1.0%/10a, whereas the proportion of melt runoff decreased at a rate of 0.07%/10a during the study period.
Predictive Model Based on K-Nearest Neighbor Coupled with the Gray Wolf Optimizer Algorithm (KNN_GWO) for Estimating the Amount of Phenol Adsorption on Powdered Activated Carbon
Authors: Zamouche Meriem , Chermat Mouchira , Kermiche Zohra , Tahraoui Hichem , Kebir Mohamed , Bollinger Jean-Claude , Amrane Abdeltif , Mouni Lotfi
Published: January 2023

In this work, the adsorption mechanism of phenol on activated carbon from aqueous solutions was investigated. Batch experiments were performed as a function of adsorbent rate, solution temperature, phenol initial concentration, stirring speed, and pH. The optimal operating condition of phenol adsorption were: mass/volume ratio of 0.6 g.L−1, temperature of 20 °C and stirring speed of 300 rpm. The equilibrium data for the adsorption of phenol were analyzed by Langmuir, Freundlich, and Temkin isotherm models. It was found that the Freundlich and Temkin isotherm models fitted well the phenol adsorption on the activated carbon and that the adsorption process is favorable. The Langmuir equilibrium isotherm provides a maximum adsorption of 156.26 mg.g−1 at 20 °C. The pseudo-first-order, pseudo-second-order, intraparticle diffusion, and Boyd models were used to fit the kinetic data. The adsorption kinetics data were well described by the pseudo-second-order model. The kinetic was controlled by the external diffusion by macropore and mesopore, as well as by the micropore diffusion. The thermodynamic study revealed the exothermic and spontaneous nature of phenol adsorption on activated carbon with increased randomness at the solid-solution interface. On the other hand, a very large model based on the optimization parameters of phenol adsorption using k-nearest neighbor coupled with the gray wolf optimizer algorithm was launched to predict the amount of phenol adsorption. The KNN_GWO model showed an advantage in giving more precise values related to very high statistical coefficients (R = 0.9999, R2 = 0.9998 and R2adj = 0.9998) and very low statistical errors (RMSE = 0, 0070, MSE = 0.2347 and MAE = 0.2763). These advantages show the efficiency and performance of the model used.
Wetlands in the Pleistocene Steppe-Tundra Landscapes of Beringia, Their Insects, and the Role of Aeolian Sedimentation
Authors: Kuzmina Svetlana
Published: January 2023

Analysis of the database of Beringian subfossil insect assemblages showed a relatively low role of aquatic, riparian, and wetland species of insects with hard exoskeleton in the Pleistocene communities and an increase in their proportions and taxonomic diversity in the Holocene. Aquatic insects were represented in all types of geological deposits and in some paleosols, but their proportions varied in different depositional environments. Poor representation of aquatic insects and a lack of freshwater invertebrates in the Late Pleistocene ice-rich deposits of Beringia called Siberian Yedoma or Yukon Muck attest to the predominantly aeolian origin of this phenomenon.
Bragg Resonance of Water Waves by Multiple Permeable Thin Barriers over Periodic Breakwaters
Authors: Tran Chang-Thi , Lin Chitsan , Tsai Chia-Cheng
Published: January 2023

In this study, the Bragg resonance of water waves scattered by multiple permeable thin barriers over a series of periodic breakwaters was solved by employing the eigenfunction matching method (EMM). The geometrical configuration was divided into multiple shelves separated by steps, on which thin permeable barriers were implemented. The solution was approximated using eigenfunctions with unknown coefficients that were considered as the amplitudes of the water waves for each shelf. The conservations of mass and momentum were then applied to form a system of linear equations, which was sequentially solved by a sparse-matrix solver. The proposed method degenerates to traditional EMM formulations if thin barriers, the permeability of the barrier, or bottom undulations are not considered. The validity of the suggested method was examined based on the results in the literature. Bragg resonances by bottom-standing, surface-piecing, and fully submerged permeable barriers over a series of periodic trapezoidal or half-cosine breakwaters were studied. In addition, the breakwater amplitudes, permeable parameters of the barriers, and incident angles of water wave scattering by different types of periodic breakwaters were discussed.
Analisis kemampuan pemecahan masalah dengan menerapkan blended learning berbantuan edmodo
Authors: Rozalina Shelly , Nurdalilah Nurdalilah
Published: January 2023

This study aims to analyze students' problem-solving abilities in solving problems on flat-sided geometric shapes by applying Edmodo-assisted blended learning. This research method uses qualitative methods with a descriptive approach. This study describes students' mathematical problem-solving abilities in the process of learning mathematics with the help of Edmodo. The subjects used in this research were class VIII-A students at MTsS Al-Washliyah Pulau Gambar, which currently consists of 20 students. The data collection used was in the form of math problem-solving ability tests and interviews. Based on the results of the study, which showed that the problem-solving abilities of students with the help of Edmodo were able to provide an understanding of the problems of questions on flat-sided geometric material, The results of the percentage of problem-solving abilities in the high-level category are 50%, the medium-level percentage is 25%, and the low-level percentage is 25%. To further strengthen the results, a sample of five students will be interviewed at various levels of ability. However, students showed a positive response to Edmodo-assisted learning media.
Hypomorphic PKD1 Alleles Impact Disease Variability in Autosomal Dominant Polycystic Kidney Disease
Authors: Gulati Ashima , Dahl Neera K. , Hartung Erum A. , Clark Stephanie L. , Moudgil Asha , Goodwin Julie , Somlo Stefan
Published: January 2023

Key Points

Autosomal dominant polycystic kidney disease (ADPKD) manifesting earlier than expected on the basis of family history can identify clinically tolerant PKD1 alleles with reduced expression.

Hypomorphic PKD1 alleles can cause mild kidney disease or liver cysts in the absence of clinically manifest kidney involvement.

The presented data highlight pleiotropic ADPKD clinical presentations and varying severity of kidney disease from PKD1 allele combinations.
Comparação de performance entre telas de poliutretano autolimpantes e telas de aço aplicadas em peneiramento a umidade natural de minério de ferro
Authors: Ferreira Antonio Eustáquio , Rodrigues Roberto Carlos , Oliveira Talita Ribeiro de
Published: January 2023

As telas para peneiramento são de basicamente 3 tipos: aço, poliuretano e borracha, sendo que só os dois primeiros são utilizados para operações à úmido ou umidade natural. As telas de aço, são comumente adotadas principalmente por possuírem maior área aberta e menor custo, mas, possuem vida útil curta quando comparadas as de poliuretano. Assim, para comparação entre o desempenho dessas telas no tratamento de minério de ferro, foram utilizadas duas peneiras iguais, uma com telas de aço e outra com telas de poliuretano. Apesar de menor área aberta, tanto nos quesitos taxa de alimentação, custo, produção de sucata metálica, peso, vida útil e tempo de limpeza, as telas de poliuretano tiveram performance superior, principalmente a vida útil 6x maior que a de aço. Assim, considerando produtividade, as telas de poliuretano performam maior utilização física e disponibilidade física além dos quesitos sustentabilidade, pela menor geração de sucata, do mesmo modo que maior segurança e ergonomia na movimentação das telas para os funcionários.
O encorajamento como aspecto de vitalidade para empreender na população 60 +
Authors: Squilante Marcelo Fernandes
Published: January 2023

Devido ao aumento da expectativa de vida das pessoas, o número de idosos tem aumentado no mundo todo, inclusive no Brasil, fazendo com que haja também algumas mudanças no modo com a sociedade se comporta. Visto a expectativa de vida atual do brasileiro ser de 74 anos, os idosos, com idade a partir dos 60, passam a buscar mais significado para a sua vida, começando a ter mais planos para o futuro, sendo o empreendedorismo um deles. Embora o tema sobre o ato de empreender contemple, na maioria das vezes, um público mais jovem e com mais habilidade para o uso da tecnologia, o presente artigo tem como objetivo abordar o empreendedorismo após os 60 anos, usando como metodologia uma revisão de literatura, além de apresentar alguns casos reais de pessoas que começaram a empreender na terceira idade. Como resultado, o presente estudo aponta que é possível ter uma história de sucesso com o empreendedorismo, mesmo passando dos 60 anos.
Doença pulmonar obstrutiva crônica gold D exacerbado com esforço respiratório – relato de caso
Authors: Novaes Kellen Larissa Maciel , Araujo André Guimarães , Assuncao Gilcilene Vieira , Lucas Junior Carlito José , Da Silva Luana Martins
Published: January 2023

Introdução: A doença pulmonar obstrutiva crônica (DPOC) é uma doença que cursa com obstrução do fluxo aéreo causada por resposta inflamatória átipica. Seu principal fator de risco é o tabagismo, tornando-a uma doença passível de prevenção. Objetivo: Relatar o caso de um paciente portadora de DPOC e seu tratamento Método: Entrevista com o paciente, registro dos métodos diagnósticos aos quais o paciente foi submetido e comparação com a literatura atual. Relato: Paciente 57 anos, sexo feminino com histórico patológico pregresso de hipertensão arterial sistêmica (HAS) e doença pulmonar obstrutiva crônica (DPOC) gold B. Evoluindo pra exacerbação do quadro e internação para controle. Considerações finais: O caso cursou conforme esperado, apesar da melhora apenas após instauração do tratamento de fisioterapia respiratória com a ventilação não invasiva.
Atendimentos em psicoterapia na pandemia de Covid-19 e seu impacto na atenção básica: uma análise retrospectiva
Authors: Cunha Américo Martins da , Oliveira Isabela Laguardia Costa Roriz de
Published: January 2023

A pandemia do novo-Coronavírus, iniciada em 2020 e com extensão até os dias atuais, alterou várias determinantes sociais de saúde. Tal alteração, de forma aguda ou cronicamente, significa, em muitos casos, o adoecimento, físico ou mental, da população de forma geral, com demanda especial da atuação dos profissionais da Atenção Básica, a qual constitui a porta de entrada para o Sistema Único de Saúde (SUS). No contexto da pandemia, houve aumento de transtornos psiquiátricos os quais demandam atuação multidisciplinar para seu manejo adequado, com destaque especial para  a integração do atendimento médico com o atendimento psicológico/psicoterapêutico. Os transtornos mentais comuns (TMC) são desses que aumentaram durante a pandemia e seu tratamento envolve, na maior parte dos casos, abordagem médica, psicoterapêutica e/ou psicofarmacológica. A psicoterapia já se mostrou eficaz na remissão dos sintomas e na prevenção de recidivas dos TMC. Por isso, o objetivo do presente trabalho é analisar retrospectivamente o número de atendimentos em psicoterapia realizados nos dois anos anteriores ao início da pandemia, 2018 e 2019, comparativamente aos dois principais anos de seu desenvolvimento até o momento, 2020 e 2021. Para tanto,  foram utilizados dados coletados na plataforma TABNET, especificamente no DATASUS. Do mesmo modo, foram realizadas buscas nas plataformas científicas mais conhecidas, como SCIELO e PUBMED,  para estabelecer um paralelo entre os achados do presente estudo e os achados da literatura científica mais atual. Conclui-se que, durante a pandemia, apesar do aumento da demanda pela atuação dos psicólogos, houve redução do número de atendimentos em psicoterapia em cerca de 21%, comparando com os anos anteriores. Essa redução implica em maiores dificuldades no manejo dos TMC, sobretudo na atenção básica, a qual só não foi maior pelo rápido desenvolvimento de metodologias para atendimento psicológico à distância/on-line, a chamada telessaúde. Os motivos dessa redução são, principalmente, as diversas medidas restritivas e de isolamento impostas para conter as infecções pelo SARS-COV-2 e o temor de adoecer por parte da população, com perda de seguimento por grande parte dos pacientes. Mais estudos, entretanto, são necessários para caracterizar melhor essa realidade.
Teor de agrotóxico na manteiga como indicador de contaminação ambiental
Authors: Santos Emili Martins dos , Monteiro Angelo da Silva , Lima Claudivan Costa de
Published: January 2023

O objetivo do presente trabalho foi avaliar a contaminação ambiental por agrotóxicos na manteiga bovina proveniente de rebanho manejado convencionalmente, em área de pastejo do município de Major Isidoro, Alagoas, Brasil. Para tanto, foram coletadas quatro amostras de manteiga sendo três de laticínios do município de Major Isidoro-AL e uma de “manteiga orgânica”, submetida a fiscalização federal, produzida na mesma mesorregião fisiográfica do referido município, a qual foi tomada como referência. Foi amostrada também uma ração servida aos animais, formulada com insumos externos. Estas amostras foram submetidas a caracterização de acordo com a legislação brasileira (Portaria nº 146/1996) e realizada análise de resíduo de agrotóxico nas manteigas e na ração coletada, conforme CODEX Alimentarius. Foram detectados a presença de princípios ativos de Clorpirifós (0,052 mg kg-1) e do Fipronil (0,011 mg kg-1) apenas na “manteiga orgânica”. Na amostra de ração foi detectada a presença de Cipermetrina, na concentração de 0,02 mg kg-1, em teor abaixo do LMR de 0,05 mg kg-1 estabelecido pela Agência Nacional de Vigilância Sanitária (ANVISA). Não foi detectada presença de resíduos de agrotóxicos nas manteigas bovinas obtidas a partir de leite produzido no município de Major Isidoro-AL. Novas investigações devem ser realizadas em matrizes como água, solo e plantas para subsidiar pesquisas futuras sobre o uso da manteiga como indicador de contaminação ambiental da área de pastejo.
Otimização do processo de gaseificação da biomassa de resíduos de madeira em água supecrítica utilizando abordagem termodinâmica
Authors: Silva Bryan Santos , Junior Julles Mitoura dos Santos , Freitas Antônio Carlos Daltro de
Published: January 2023

Dentre os resíduos gerados pelas indústrias está a madeira de eucalipto, uma alternativa para o tratamento desse tipo de resíduo são métodos de reforma. Um desses métodos de reforma empregados, e o utilizado neste trabalho é a gaseificação com água supercrítica (SCWG) com o objetivo de produzir hidrogênio (H2). Dito isto, foi realizada a otimização do processo de SCWG utilizando duas abordagens termodinâmicas, a minimização da energia de Gibbs (que descreve o comportamento de sistemas isotérmico) e a maximização da entropia (que descreve o comportamento de sistemas adiabáticos). As metodologias foram resolvidas com o auxílio do software GAMS, e foi possível verificar o perfil de produção dos diversos gases da SCWG e o comportamento dos mesmos nas diferentes condições de operação, as reações foram feitas fixando a pressão em 230 atm, e utilizando uma faixa de temperatura de 823 a 1423 K, obteve-se formação máxima de 1,15 mols de H2 quando o sistema opera a uma temperatura de 1323 K e uma alimentação de 20% wt de biomassa de cavaco de eucalipto.
Bacillus amyloliquefaciens, Microbacterium Resistens e Stenotrophomonas Maltophilia no biocontrole de Corynespora Cassiicola na cultura do tomate
Authors: Monteiro Gersimar Pereira , Vasconcelos Aldenora dos Santos , Hanada Rogério Eiji , Blind Ariel Dotto , Silveira Tagleorge Marques
Published: January 2023

Este artigo apresenta uma abordagem sobre o uso de controle biológico aplicando a ação de bactérias contra Corynespora cassiicola (Bert & Curt) Wei pois este é um dos principais fitopatógenos de propagação aérea que limita a produtividade das solanáceas. A utilização de bactérias no controle de doenças em solanáceas é uma metodologia em difusão, pois o biocontrole de fitopatógenos realizado por bactérias pode ocorrer por diferentes mecanismos como a inibição por antibióticos, o parasitismo, a competição pelo espaço físico ou a indução de resistência da planta ao ataque de patógenos. Esta pesquisa visou selecionar, identificar e avaliar in vitro e in planta bactérias antagonistas com potencial para desenvolvimento de um bioproduto que contribua para o desenvolvimento agrícola sustentável de tomate. As coletas e os testes in planta foram realizadas na Estação Experimental de Hortaliças Dr. Alejo von Der Pahlen, KM 14 da estrada AM 010 (S: 02° 59’ 45,7” e W: 60° 01’ 22,3”). Os testes in vitro foram realizados na Embrapa Amazônia Ocidental. Os resultados indicam que o Bacillus amyloliquefaciens, apresentou 75,73% de inibição do C. cassiicola in vitro e 56% de controle da mancha-alvo quando comparado ao Microbacterium resistens e a Stenotrophomonas maltophilia nos testes em tomateiro.
A superforça e outros aspectos notáveis na obra A Metamorfose, de Franz Kafka
Authors: Neto Moisés Monteiro de Melo , Silva Aryane Rikelly Lira da , Souza Larissa de França , De Souza Myllena Silva , Souza Rita de Cássia Tenório da Silva
Published: January 2023

O presente artigo busca analisar, a trajetória de vida e a força existente na obra do escritor judeu tcheco Franz Kafka. A Metamorfose, narra a história de um caixeiro-viajante, que ao acordar vê seu corpo metamorfoseado em um instituição inseto. Levando em consideração a principal dúvida que surge ao leitor – O que faz com que Gregor se transformasse em um inseto? – desenvolvemos esse estudo para estudar a representação do sujeito fragmentado na referida obra. Para tanto, tivemos como amparo teórico as pesquisas de alguns estudiosos da obra kafkiana, tais como: Modesto Carone, Harold Boom, Otto Maria Carpeaux, Salvatore D´Onofrio, Eduardo Manoel Brito e Flávio Costa Moreira.
Os potenciais do Iramuteq para análise de conteúdo de decisões judiciais
Authors: Melo Ulisses Matheus Braga de Freitas , Souza Laís Oliveira de
Published: January 2023

O seguinte paper apresenta a técnica de Análise de Conteúdo automatizada aplicada em decisões judiciais. O objetivo é demonstrar os potenciais usos do software Iramuteq para o estudo do comportamento jurisdicional dos tribunais, bem como as linhas argumentativas e jurisprudenciais mais utilizadas. O Iramuteq possibilita, via uma interface acessível, o desenvolvimento de análises lexicais básicas, análise de especificidades, classificação hierárquica descendente, análise de similitude e nuvem de palavras. Os resultados obtidos a partir de análises iniciais demonstram a capacidade técnica desses métodos, bem como abrem caminho para novas agendas de pesquisa dentro da academia jurídica.
Os efeitos danosos do ativismo judicial: banalização das prisões cautelares
Authors: Semmer Eduardo Henrique Cordeiro
Published: January 2023

Versa o presente artigo sobre os efeitos danosos do ativismo judicial, em especial com relação à banalização das prisões cautelares, por meio do qual se objetiva destacar que, além da interferência do Poder Judiciário nas competências dos outros poderes da República, para tratar de assuntos relacionados a direitos e garantias individuais e coletivos, a postura proativa dos magistrados tem levado a decretações de medidas indevidas, dentre as quais prisões cautelares ilegais, muitas vezes com apoio popular, como foi o caso da recente operação Lava-Jato. De modo a circunstanciar o tema, além de salientar os principais aspectos conceituais das prisões cautelares, o estudo busca caracterizar o ativismo judicial, salientando a ocorrência de prisões ilegais decorrentes dessa postura ativa dos magistrados.
Osteogênese imperfeita: diagnóstico clínico, radiológico e laboratorial
Authors: Araújo Wanessa Lemos , Vasconcelos Ana Paula Alves Cunha , Nascimento Deise Gonçalves do , Oliveira Gabriela Aquino de , Santos Julianna Patrícia Augusto dos , Caires Laryssa Thompson Vieira , Oliveira Letícia Almeida de , Siqueira Paula Fernanda Oliveira Metello de , Downing Paulina Grace , Martins Pauliane Paula , Conceição Rafael Amanso de , Durães Ruanner Ronann Marques
Published: January 2023

A osteogênese imperfeita (OI) é uma patologia geneticamente determinada, afetando diretamente estruturas e funções do colágeno tipo I, sendo este, representante de 90% de todo o colágeno tecidual, e responsável por grande parte dos tecidos fibrosos densos, que formam o sistema muscular esquelético. Trata-se de uma doença rara, a depender da classificação, dividida em dois grandes grupos, ‘’congênita’’ e ‘’tardia’’. Por certo, o diagnóstico é feito a partir do histórico do paciente, quadro clínico, aspecto ao exame físico e resultados radiográficos, inexistindo um exame específico e complementar para uma confirmação da doença, isto tudo devido a diversidades de apresentações fenotípicas, porém sempre com fragilidade óssea marcantes, frouxidão cápsulo-ligamentar, esclera com a cor azulada, surdez, dentinogênese imperfeita, deformidade nos ossos longos e hiperextensibilidade articular. Devido a vasta forma de apresentação, a OI possui como diagnósticos diferenciados, categorias baseadas em estágios de vida do paciente, devendo-se considerar três estágios, pré-natal/neonatal, infância e adolescência.  Por se tratar de uma condição genética, com todos os estudos e apesar dos avanços tecnológicos, não existe uma cura para a OI, porém existem três formas fundamentais para tratamentos da doença, a forma terapêutica, a cirúrgica ortopédica e a reabilitação. Todo o prognóstico depende da forma como a OI se apresenta, o prognóstico pode ser muito variável, será observado o grau de severidade e acompanhamento terapêutico.
Heat transfer in a simulated spent fuel pool for different types of spent fuels
Authors: Faria Fernando Pereira de , Godino Dario Martin , Corzo Santiago Francisco , Ramajo Damián Enrique , Costa Antonella Lombardi , Lima Cláubia Pereira Bezerra
Published: January 2023

Historically, the Spent Fuel Pool (SFP) of Angra II, from Brazil, has received standard spent fuel (SF) assemblies of uranium dioxide (UO2) discharged from Pressurized Water Reactors (PWR) of the Nuclear Power Plants (NPP) of Angra. However, in case of using Mixed Oxide (MOX) or thorium-based fuels at a proportion of 1/3 or 1/4 of the total of fuel assemblies in their PWRs as it has been occurring worldwide, it would require further thermal studies of wet storage of the new mixed SF generated. It includes the determination of the water boiling time (Tb) of the SFP in case of breakdown of its external cooling system (ECS). This work presents studies of Tb of a simulated SFP storing mixed SF discharged from PWRs. The types of mixed SF studied include MOX plus UO2, oxide of thorium/uranium (U-Th)O2 plus UO2, and oxide of thorium/transuranic (TRU-Th)O2 plus UO2. All the mixed SF was considered to contain 1/3 or 1/4 of either thorium-based fuels or reprocessed fuel.  The simulations were implemented in CFX Ansys and OpenFOAM© codes. Tb from simulations with Ansys ranged from 4.05 h to 5.97 h, and from 3.45 h to 5.77 h from simulations with OpenFOAM©. Results show that, independent of the mixed loading pattern of the SFP, the water would reach the saturation temperature more rapidly when (TRU-Th)O2 was present. By contrast, when MOX was present, Tb was greater.
Relações perigosas: improbidade e corrupção na interação entre a indústria de saúde e profissionais médicos públicos
Authors: Giamundo Camillo , Queiroz Joaquim Augusto Melo de
Published: January 2023

Os profissionais da medicina e a indústria de medicamentos e produtos para saúde possuem uma relação intrínseca. Tal relação representa um passo fundamental para o desenvolvimento de novas tecnologias uma vez que auxilia na pesquisa de soluções inovadoras e sua respectiva viabilidade comercial. No entanto, praticar a medicina de modo adequado e evitar possíveis conflitos de interesse é essencial. O objetivo do presente artigo é estudar essa interação, seus aspectos econômicos, e a definição de premissas e consequências jurídicas a fim de propiciar uma relação transparente, ética e idônea.