bluuebunny/crossref_metadata_2025 huggingface dataset:
Growth patterns of Pseudomonas aeruginosa in milk fortified with chitosan and selenium nanoparticles during refrigerated storage
Authors: Atia Rehab M. , Mohamed Hamdi A. , ELRoos Nahla A. Abo , Awad Dina A.B.
Published: May 2023

Pseudomonas spp are considered the most common milk-associated psychotropic bacteria, leading to milk deterioration during storage so, our study aimed to study the growth behavior of Pseudomonas aeruginosa in milk after employing chitosan nanoparticles (CsNP 50, 25 and15 mg/100ml) and selenium nanoparticles (SeNP 0.5, 0.3 and 0.1mg/100ml) as a trial to control the bacterial growth in milk during five days of cooling storage. Our study relies on using ion gelation method and green synthesis for conversion chitosan and selenium to nanosized particles, respectively, we subsequently confirmed their size and shape using SEM and TEM. Depending on using Pseudomonas selective agar medium supplemented by glycerol for monitoring the bacterial growth along the cooling storage. Our findings reported that, both synthesized nanoparticles exhibit antibacterial activity in a dose dependent manner. Moreover, the uniform aggregated with average size 60 ± 5 nm CsNP50 could inhibit the P. aeruginosa survival growth to mean average 2.62 ± 1.18 log10cfu/ml in the fifth day of milk cooling storage, also it was noted that the hexagonal particles with average size 20 ± 5nm SeNP0.5 could inhibit 2.49 ± 11 log10cfu/ml in comparison to, the control P. aeruginosa milk group exhibited growth survival 7.24 ± 2.57 log10cfu/ml under the same conditions. As conclusion, in order to improve milk safety, we suggest employing chitosan and selenium nanoparticles.
Sub-classifying Neuroblastoma: A Comparative Study of Clinical Characteristics and Survival Outcomes in Neuroblastoma and Ganglioneuroblastoma
Authors: Wu Xiongwei , Wang Jianyong , Liu Yao , Dong Qian
Published: May 2023

Objective:Neuroblastoma (NB) and Ganglioneuroblastoma (GNB) are the most common extracranial solid tumors in children, with different clinicopathological features and survival outcomes. The aim of this study is to compare the demographic, clinical features, and survival outcomes of patients with NB and GNB.Method:We retrospectively extracted data from patients with NB and GNB from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2019. We analyzed the demographic and clinical characteristics using Pearson’s chi-squared test or Fisher’s exact test. Kaplan-Meier curves were utilized to compare cancer-specific survival (CSS) and overall survival (OS) among different subgroups. Multivariable Cox proportional hazards regression analysis was used to estimate the independent prognostic factors for CSS and OS.Results:A total of 1,968 patients under 14 years of age were included in this study, of whom 1,609 (81.7%) were diagnosed with NB and 359 (19.3%) with GNB. The majority of GNB patients were over 2 years old (83.57%), while most NB patients were under 2 years old (58.42%). Survival analysis revealed that the OS of GNB patients was superior to that of NB patients. In addition, multivariate Cox regression analysis identified chemotherapy and tumor site as independent prognostic factors for GNB patients, while age, surgery, chemotherapy, tumor size, and tumor site were independent prognostic factors for NB patients.Conclusions:This study provides insights into the significant differences between NB and GNB in terms of demographic, clinical features, and survival outcomes. Our findings have important implications for informing clinical decision-making and providing more targeted therapeutic options for patients with these tumors. Further studies are necessary to validate our findings and explore the underlying biological mechanisms.
On the dynamic of discrete-time Rayleigh-Duffing oscillators
Authors: Khajoei Najmeh , Nia Mehdi Fatehi , Nurkanović Zehra
Published: May 2023

This paper investigates the dynamics of discrete-time Rayleigh-Duffing oscillator by applying the forward Euler's scheme. It is shown that the system undergoes Hopf bifurcation and flip bifurcation by using the center manifold theorem and bifurcation theory. Also, it is proven the system possesses chaotic behavior in the sense of Marotto's definition. We compute the Lyapunov exponents numerically to show sensitive dependence to initial conditions and chaotic behavior.
MSC Classification: 39A10 , 39A20 , 39A23 , 39A30 , 65L20
Effects of Clostridium autoethanogenum protein on growth performance, intestine and liver health of turbot Scophthalmus maximus during grow-out phase
Authors: Bai Nan , Li Qing , Pan Shihui , Qi Zezheng , Deng Wanzhen , Gu Min
Published: May 2023

Clostridium autoethanogenum protein (CAP) is an emerging protein source with several key advantages and it has investigated on juvenile turbot (9.13 g). However, it was indicated that fish growth stage is a decisive factor for CAP performance and the influence of CAP on turbot intestine health has not been reported. Thus, it is worth investigating the effects of CAP on turbot extensively. In the present study, a 67-day feeding experiment was conducted to evaluate the effects of CAP on turbot in the grow-out phase from growth performance, intestine and liver health. Six hundred and thirty turbot with an initial body weight of about 150 g were randomly divided into 6 groups, which were fed with fishmeal-based control diet or diet with CAP to replace 15%, 30%, 45%, 60% and 75% of fishmeal protein in control diet, respectively. From growth and feed utilization, the substitution level of CAP should no more than 30%, which was less than previous reported on juvenile turbot. The palatability of the feed was linearly reduced. Although CAP did not induce enteritis, it decreased the intestine villi height in middle and intestine villi density in distal intestine. Except for decreasing the size of hepatocytes by CAP at 45% or higher substitution levels, no other abnormality observed in liver histology. However, dietary CAP reduced the triglyceride and cholesterol levels in the plasma at 30% or higher levels and linearly down-regulated genes related to lipogenesis in liver. The genes related lipid transportation and oxidation were up-regulated by CAP at the substitution levels of 15–60%. The present work confirmed the safety of CAP in fish feed and suggested more work should be conducted before it widely used in aquafeed.
Enhanced electric field and charge polarity modulate the microencapsulation and stability of electrosprayed probiotic cells (Streptococcus thermophilus, ST44)
Authors: Dima Panagiota , Stubbe Peter Reimer , Mendes Ana C. , Chronakis Ioannis S.
Published: May 2023

The “organization” of Streptococcus thermophilus (ST44) probiotic cells within maltodextrin microcapsules was investigated, using electrospray processing. The generated electrostatic forces between the negatively surface-charged probiotic cells and the applied negative polarity on the electrospray nozzle, allowed to control the location of the cells towards the core of the electrosprayed microcapsules. The “organization” of the cells affected the evaporation of the solvent (water) and subsequently the glass transition temperature (Tg) of the electrosprayed microcapsules. Moreover, the utilization of auxiliary ring-shaped electrodes, between the nozzle and the collector, enhanced the electric field strength and contributed further to the increase of the Tg. Numerical simulation, through Finite Element Method (FEM), shed light to the effects of the additional ring-electrode on the electric field strength, potential distribution, and controlled deposition of the capsules. Moreover, the viability of the encapsulated cells was significantly improved for up to 2 weeks of storage at 25°C and 35% RH, when the cells were located at the core of the microcapsules, compared to the probiotics distributed towards the surface. Overall, this study presents a novel method to manipulate the encapsulation of the surface charged probiotic cells within electrosprayed microcapsules, utilizing the polarity of the electric field and additional ring-electrodes.
Colonic Microbiota Improves Fiber Digestion Ability and Enhances Absorption of SCFAs in Hainan Local Pigs
Authors: Xue Pengxiang , Luo Yabiao , Song Yanxia , Tang Qiguo , Wang Feng , Sun Ruiping , Chao Zhe , Fang Meiying
Published: May 2023

Background
Compared to commercial breeds, Chinese local pig breeds have a greater ability to digest dietary fiber, which may be due to differences in intestinal microbiota. Previous studies on the adaptation of dietary fiber either considered only feed factors or breed factors. Therefore, this study took both of these factors into consideration for the experimental design in order to explore the potential causes of high dietary fiber adaptation of Ding’an pigs.
Results
Compared with commercial pigs, Ding’an pigs have a stronger ability to digest dietary fiber. Prevotella was more prevalent in Ding’an pigs than in DLY pigs, which may be an important reason for the stronger ability of fiber degradation in Ding’an pigs. When the effects of feed and breed factors are considered, differences in abundance of 31 species and 14 species, respectively, may result in a greater ability of fiber degradation in Ding’an pigs. Among them, Prevotella. sp. CAG:520 may be a newly discovered bacterium related to fiber degradation, which positively correlated with many fiber-degrading bacteria. We also found that the concentration of plant metabolites with anti-inflammatory and antioxidant effects was higher in the colonic chyme of Ding’an pigs after increasing the fiber content, which resulted in down-regulated expression of inflammatory factors in colonic mucosa. Spearman’s correlation coefficient revealed a strong correlation between microbiota and apparent digestibility of dietary fiber. The mRNA expressions of SLC16A1, PYY and GCG were significantly increased in the colonic mucosa of Ding’an pigs fed on high-fiber diets, which indicates that Ding’an pigs have an enhanced absorption of SCFAs.
Conclusions
Our results suggested that an appropriate increase in dietary fiber content can reduce the inflammatory response and improve feed efficiency in Ding'an pigs, and differences in the intestinal microbial composition may be an important reason for the difference in the fiber degradation capacity between the two breeds of pigs.
Identification of immune subtypes and response prediction to immune-checkpoint inhibitors for MDM4 gain/amplification luminal A type breast cancer
Authors: Zhao Fei , Wang Na-Na
Published: May 2023

Objective:The aim of this work was to identify the consensus immune subtypes and predict the response to immune checkpoint inhibitor (ICIs) therapy for MDM4 gain/amplification luminal A type breast cancer (BC).Materials and Methods:Luminal A type BC expression data, copy number and corresponding clinical information were downloaded and pre-processed for subsequently analysis from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). Furthermore, gene set enrichment analysis (GSEA) was performed to identify transcripts functions between MDM4 gain/amplification and control samples. Subsequently, weighted gene co-expression network analysis (WGCNA) was applied to screen out gene modules related biomarkers for ICIs therapy response in luminal A type BC. We perform an unsupervised consensus clustering in MDM4 gain/amplification luminal A type BC from TCGA BC dataset based immune-related gene signatures (IRGs) and then used luminal A type BC from METABRIC BC as validation datasets. We performed the Tumor Immune Dysfunction and Exclusion (TIDE) analysis to predict ICIs response and explore significant relationship with immune subtype.Results:The results from GSEA indicated that luminal A type BC with MDM4 gain/amplification were significantly enriched in immunological signature gene sets. Significantly, we also identified three gene modules significantly association with immune checkpoint, DNA damage, and immune cell infiltering in luminal A type BC. Luminal A type BC could be categorized into two distinct immune subtypes based on the expression of IRGs. Luminal A type BC in one subtype showed high response to ICIs therapy, characterized by higher immune checkpoint genes score and CD8+T-cell score compared to tumors in a second subtype.Conclusion:Our findings demonstrated that immune subtype for MDM4 gain/amplification luminal A type BC was beyond the current luminal A/B classification and a subset of luminal A type BC patients may benefit from ICIs therapy.
The Effect of Distribution of the Perforation Density on the Production Through Perforated Horizontal Wellbore
Authors: Kareem¹ Hasanain J. , Hasini Hasril , Abdulwahid Mohammed A.
Published: May 2023

With depletion of oil reserve around the world, focus has been shifted towards deeper exploration in the field that is difficult to reach. Oil production rate is influenced by perforation density distribution's along horizontal wells, specifically in reservoirs with high permeability and low-pressure drawdown. This study investigated the behaviours of the total pressure drop, mixture’s superficial velocity, void fraction and liquid film thickness that occurs with various flow patterns (i.e., bubble, slug, stratified and stratified wave flows). Two perforation density conditions are studied, namely perforation density increase at outlet and perforation density increase at inlet. The friction factor was fulfilled through the perforated and unperforated horizontal wellbore. Production is greater with a perforated horizontal wellbore than with a smooth (unperforated) horizontal wellbore. The total pressure drop, mixture superficial velocity and void fraction increases with the air superficial velocity when the water superficial was constant. The liquid film thickness decreases when the air superficial velocity increased, while the pressure drops increase with increases of mixture Reynolds number. The liquid and air products increase when the perforation density increases at the inlet section (and decreased at the outlet section) of the perforated horizontal wellbore. It was noted that the air product increased with the air flow rate. Liquid product increases with the bubble flow as the transition point of the bubble/stratified flow decreased. Validation with experimental data, as well as data from other researchers show good agreement, conforming the reliability of the numerical code used in this study. The convergence between the results is good through the patterns (bubble flow, dispersed bubble flow, slug flow, transition bubble/stratified flow, and transition stratified/stratified wave flow).
Transcriptomic and lipidomic analysis reveals the salt-adapted in Salicornia europaea
Authors: Yang Lei , Bai Yang , Yang Jiahui , Gao Yunyan , Shi Panpan , Hou Chenxue , Wang Yanzhi , Gu Xinlu , Liu Weizhong
Published: May 2023

Halophytes have evolved unique strategies to cope with salinity. Salicornia europaea, a succulent euhalophyte plant, show optimal reproduction under 200 mM NaCl. However, the role of lipid metabolism caused by salinity in S. europaea is not fully understood. To gain insight into this, we conducted a combined lipidomic and transcriptomic analysis to investigate the molecular basis of lipid metabolism in response to 0 and 200 mM NaCl. GO and KEGG analysis revealed that salt treatment mainly affected glycosylphosphatidylinositol (GPI) anchored biosynthesis, secondary metabolite synthesis, plant hormone signal transduction, peroxisome, and glycosphingoipid biosynthesis. We identifited 485 lipid compounds, 27 of which showed altered abundances under salt treatment. Notably, lysophosphatidylcholine (LPC) and phytosphingosine-1-phosphate (S1P) significantly increased, while polyunsaturated monogalactosyldiacylglycerols (PA), lysophosphatidylinositol (LPI), phytoceramides with hydroxylated fatty acyl (PhytoCer-OHFA), phyto-glucosylceramide (Phyto-GluCer), sphingosine (Sph), and phytosphingosine (PhytoSph) markedly decreased. Additionally, the increase in DBI index was mostly phospholipids and sphingolipids, indicating that the lipid saturation was reduced, and the fluidity was higher, which may be related to the strong salt resistance of S. europaea. By comparing the average carbon chain length (ACL), it can be seen that the ACL coefficient of S1P is significantly reduced with 200 mM NaCl concentration, so we speculate that S1P may be related to the salt resistance.
[(EtO) 3 Si(CH 2 ) 3 N + H 3 ][CH 3 COO - ] as basic ionic liquid catalyst promoted green synthesis of benzo[a]pyrano[2,3-c]phenazine derivatives
Authors: Shirzaei Farhad , Shaterian Hamid Reza
Published: May 2023

An efficient, one-pot quantitative procedure for the preparation of benzo[a]pyrano[2,3-c]phenazine derivatives from four-component condensation reaction of 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamine, aromatic aldehydes, and malononitrile in the presence of [(EtO)3Si(CH2)3N+H3][CH3COO−] as basic ionic liquid as catalyst under solvent-free conditions is described. Simple procedure, high yields, short reaction times, and an environmentally benign method are advantages of this protocol. The [(EtO)3Si(CH2)3N+H3][CH3COO−] can be recovered and reused several times without loss of its activity.
Chinese Empirical Dietary Inflammatory Index Is Associated with High Risk of Systematic Inflammation and Aging in Rural China
Authors: Lyu Lu , Yu Jie , Liu Yiwen , He Shuli , Qi Mengya , Yang Na , He Liyun , Wang Jialu , Ping Fan , Xu Lingling , Zhang Huabing , Li Wei , Li Yuxiu
Published: May 2023

Background：China is rapidly transforming into an aging society and houses the largest elderly population in the world. Diet patterns increase inflammation and oxidative stress, which may provide effective intervention strategies for mitigating the health burden in aging societies. This study sought to develop a Chinese empirical dietary inflammatory index(CEDII) that assesses Chinese diet quality based on its inflammatory potential and examine whether the index was associated with an accelerated aging process.
Methods:A cross-sectional study conducted in the community of Beijing recruited 388 participants. Dietary intake was collected based on 24-h dietary recalls. The Chinese Diet Balance Index(DBI) and its derivatives, as well as the empirical dietary inflammatory pattern(EDIP) based on the western diet, were calculated to assess dietary quality in different aspects. Chinese empirical dietary inflammatory index(CEDII) was derived using reduced-rank regression(RRR) according to Chinese diet patterns. The population was categorized into tertiles of the CEDII. Leukocyte telomere length(LTL) and mitochondrial DNA copy number(mtDNAcn) were determined by polymerase chain reaction assay. Tumor necrosis factor α(TNFα) and interleukin-6(IL-6), 8-oxo-2'-deoxyguanosine (8-oxo-dG), superoxide dismutase (SOD) activities, and glutathione reductase (GR) were measured.
ResultsA total of 388 subjects were enrolled. High CEDII group was characterized by high intake of carbohydrates. This pattern predicted higher levels of TNFα, IL-6, shorter LTL and lower mtDNAcn. Neither DBI nor EDIP was correlated with biomarkers of inflammation or aging. High CEDII scores were associated with short LTL and decreased mtDNAcn using multivariate linear regression with adjustment for confounding variables. The stratified analysis demonstrated that the high CEDII group had an increased risk of short LTL in subjects with abnormal metabolic status.
Conclusions: This study developed a Chinese empirical dietary inflammatory index(CEDII). High CEDII scores were associated with an increased risk of aging. Compared with indexes related to DBI and EDIP, CEDII was much more effective in assessing inflammation and aging potential of diet patterns for Chinese residents.
Complex method of diagnosing soft potato rot caused by P. carotovorum
Authors: Zhumayeva Araigul , Bogdanov Ilgizar
Published: May 2023

Pectobacterium carotovorum bacteria are facultative pathogens which cause diseases of various plant species, in many cases causing great economic damage. The research aim is to develop a complex method for diagnosing soft potato rot caused by Pectobacterium carotovorum. Soil samples, water from open reservoirs, sewage, plant residues, and potatoes with signs of soft rot were used in the research. From 123 samples of phytosanitary control and environmental objects, 14 strains were classified as Pectobacterium carotovorum spp.carotovorum. The obtained results of research on the biological properties of bacteria isolated by us are basically consistent with the data of reference strains. Based on the developed bacteriological scheme for the identification of Pectobacterium carotovorum spp.carotovorum bacteria, including 27 indicators, 14 strains were identified, typed as Pectobacterium carotovorum spp.carotovorum. It was established that within 168 hours, using the developed scheme for isolation and bacteriological identification of bacteria Pectobacterium carotovorum spp.carotovorum, it’s possible to type the above-mentioned bacteria based on 27 tests. However, the length and material intensity of research do not allow us to say that this method is effective for routine research. Phagoidentification of isolated strains of P.carotovorum spp.carotovorum was proved by the results of checking biochemical properties of bacteria. Out of 12 samples, 5 were identified as P.carotovorum spp.carotovorum. The conducted research proves the possibility of applying the identification scheme of bacterium P.carotovorum spp.carotovorum using introduced bacteriophage biopreparation consisting of RCC bacteriophages-1 UlGAU and РСС-37 UlGAU allowing to reduce the time spent on research several times (from 168 hours to 88 hours).
Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis
Authors: Fujita Yoshinori , Fukuda Yujiro , Sanuki Fumiaki , Irei Isao , Monobe Yasumasa , Uno Masako , Akisada Takeshi , Shimoya Koichiro , Hara Hirotaka , Moriya Takuya
Published: May 2023

Background: Human papillomavirus (HPV)-associated oropharyngeal cancer occasionally has a poor prognosis, making prognostic risk stratification crucial. Protease-activated receptor-1 (PAR1) is involved in carcinogenesis and is regulated by alpha-arrestin domain-containing protein 3 (ARRDC3). It is also involved in the tumor microenvironment. We sought to evaluate the predictive ability of PAR1, ARRDC3, and tumor-infiltrating lymphocyte (TIL) scores in patients with oropharyngeal, hypopharyngeal, and uterine cervical cancers, serving as comparators for HPV-associated oropharyngeal cancer.
Methods: Immunohistochemical analysis of p16, ARRDC3, and PAR1 expression was performed for 79 oropharyngeal, 44 hypopharyngeal, and 42 uterine cervical cancer samples. The TIL scores were assessed and classified into the following groups based on invasion: Low: 0 %–10 %, Medium: 20 %–40 %, and high: >50 %. For prognostic analysis, the three groups were evaluated by dividing them into low, medium, and high categories, or alternatively into two groups using the median value as the cutoff.
Results: p16 was expressed in 44 (56 %) oropharyngeal, 8 (18 %) hypopharyngeal, and all uterine cervical cancer samples. ARRDC3 was detected in 39 (49 %) oropharyngeal, 25 (57 %) hypopharyngeal, and 23 (55 %) uterine cervical cancer samples. PAR1 was expressed in 45 (57 %) oropharyngeal, 22 (50 %) hypopharyngeal, and 22 (50 %) uterine cervical cancer samples. Patients diagnosed with p16-positive oropharyngeal cancer had a substantially improved prognosis compared to those diagnosed as p16-negative cases. Compared to the p16-positive cases, the PAR1-negative cases had a considerably improved prognosis compared to the positive cases (disease-specific survival [DSS] and -negative cases (disease-free survival [DFS]). Multivariate analysis revealed that ARRDC3-positive cases had an appreciably better DSS prognosis than patients with p16-negative oropharyngeal cancers.PAR1-positive cases among patients with p16-positive oropharyngeal cancer had a poor prognosis. With respect to DFS, patients with PAR1-positive and p16-negative oropharyngeal cancer had a 35-fold higher recurrence rate than those with PAR1-negative and p16-negative oropharyngeal cancer.
Conclusion: Our results suggest that PAR1 expression affects the prognosis and recurrence rate of HPV-associated oropharyngeal cancer.
Complete chloroplast genome sequences of the ornamental plant Prunus Cistena and comparative and phylogenetic analyses with its closely related species
Authors: Feng Lijuan , Zhao Guopeng , An Mengmeng , Wang Chuanzeng , Yin Yanlei
Published: May 2023

Background Prunus Cistena is an excellent color leaf configuration tree for urban landscaping in the world, which has purplish red leaves, light pink flowers, plant shape and high ornamental value. Genomic resources for P. Cistena are scarce, and a clear phylogenetic and evolutionary history for this species has yet to be elucidated. Here, we sequenced and analyzed the complete chloroplast (cp) genome of P. Cistena and compared it with related species of Prunus genus based on chloroplast genome.Results The complete chloroplast genome of P. Cistena was 157,935 bp in length, which had a typical tetrad structure. The overall GC content was 36.72%, while IR regions displayed a higher GC content than LSC and SSC regions. It encoded 130 genes, including 85 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. The ycf3 and clpP genes had two introns; the longest intron was trnK-UUU gene in the LSC region. There were 253 SSRs, and the mononucleotide SSRs were the most abundant. The chloroplast sequences and gene arrangements of P. Cistena were conserved, which overall structure and gene order were similar to other Prunus species. The atpE, ccsA, petA, rps8 and matK gene had significant positive selection in Prunus species. P. Cistena had a close evolutionary relationship with the P. jamasakura. The coding region and IR region were more conserved than noncoding region, and the cpDNA sequences highly conserved throughout the genus Prunus.Conclusions The current genomic datasets provide valuable information for further species identification, evolution, and phylogenetic research of genus Prunus.
Inbound marketing strategy on social media and the generation of experiences in fast food consumers
Authors: John Vasquez-Reyes Boris , Judith Bravo-Martinez Fiorela , Antonio Coral-Morante Jose , Cordova-Buiza Franklin
Published: May 2023

Digital media has allowed restaurants to maintain their sales, positioning, and better relationships with consumers in adverse situations such as the COVID-19 pandemic. This study seeks to determine the relationship between social networks as an inbound marketing tool and the generation of digital experiences in consumers of fast-food restaurants. This is a quantitative, correlational, and non-experimental analysis. The sample includes the most popular fast-food restaurants in Peru (Norky’s, Roky’s, and Kentucky Fried Chicken) that demonstrate significant presence in social networks and possess potential characteristics to provide customers with a positive experience. One hundred one respondents between 18 and 35 years of age, residents of Lima (Peru), and frequent consumers of fast food establishments were surveyed via Google Forms. The results were tabulated in MS Excel and the quantitative data analysis was performed with the IBM SPSS tool; descriptive and inferential statistics were applied and the correlation was obtained through Spearman’s coefficient. The findings highlighted that 61.39% of the respondents agree that the social network experiences of the restaurants influence their expectations; 47.5% react with likes and comments to the publications, and 63.4% recommend the restaurants thanks to the constant dissemination of their content. Finally, a significance level of less than 0.05 was obtained between the variables, demonstrating that one variable has a relationship with the other. The study concludes a moderate direct relationship between social networks as an inbound marketing strategy and the generation of digital experiences in the study group.
Encarceramento, justiça e amor: Pensar além da indiferença a partir de Levinas
Authors: Acioly Dimitri Alexandre Bezerra , Sayão Sandro Cozza
Published: May 2023

O artigo aborda a desfiguração do cidadão encarcerado como personificação do mal e a negativa de sua humanidade por discursos hegemônicos na sociedade brasileira atual. Com isso, objetiva-se problematizar a visão estigmatizante lançada sobre este grupo social e pensar novos horizontes de sentido acerca do cárcere, respeitando direitos e garantias fundamentais previstos na Constituição Brasileira e nos tratados de direitos humanos dos quais o país é signatário. O estudo situa-se interdisciplinarmente no campo dos direitos humanos e da filosofia e tem caráter eminentemente teórico-crítico, com lastro em pesquisa bibliográfica qualitativa, pois investiga a imagem do preso ao tempo que propõe intervenções neste imaginário. Instrumentalizando a ética do filósofo Emmanuel Levinas para analisar a restrição de liberdade, o trabalho reflete sobre as condições de reconhecimento da vida humana em Judith Butler, o conceito de orientalismo endógeno para Rafael Godoi e as práticas da justiça criminal com pretensão à universalidade, com Bethânia Assy. À guisa de conclusão, o artigo observa que a vociferação contra a humanidade do preso nega o arcabouço ético existente para afastar a incidência das normas protetivas contra um grupo vulnerável específico, destacando que a condenação pela prática de atitudes ilícitas não apaga a realidade da infinitude humana do preso, a qual merece amparo. Por fim, refuta a ideia da prisão como locus apartado da sociedade e cita ações de zelo com encarcerados como meio de perfurar a barreira ideológica construída entre os autodenominados “cidadãos de bem” e os rotulados “criminosos”, não dignos de amparo.
LONG-TERM TREND OF NITROGEN AND PHOSPHORUS TRANSPORT IN 12 TROPICAL COASTAL WATERSHEDS IN NORTHEAST BRAZIL
Authors: Noriega Carlos , Araujo Moacyr , L. Varona Humberto , Costa Mauricio , Calzada Amilcar , Medeiros Carmen , Silva Andrea , Portela Livia , Bezerra Daniella , Jeronimo Rivaldo , Barros Paulo , Araujo Julia , Rollnic Marcelo
Published: May 2023

Multiple environmental problems are caused by the accumulation of nitrogen (N) and phosphorus (P) in river water on its way to the ocean. The objective of this work was to determine the N and P loads in 12 hydrographic basins that flow into estuaries along the northeastern coast of Brazil using established methods. Additionally, natural and anthropogenic loads trends in the hydrographic basins of 12 tropical rivers in northeastern Brazil over 27 years (1990-2016) were evaluated. The results indicated an annual average increase of +1.1% in population density, while precipitation showed no significant trend. The anthropogenic loads were 21 and 112 times higher than natural inputs for N and P, respectively. Anthropogenic sources accounted for ~ 96% of all contributions. The positive trends of these loads (mainly wastewater) represented an annual average increase of 1.1% for N and 1.2% for P, for all river basins included in this study. These percentages represent average annual loads of 251 t N yr-1 and 54.8 t P yr-1. The time series of N and P in the study region showed trends that point to a constant increase, implying a greater contribution of these loads to the adjacent coastal region year after year.
Effects of coronavirus infection on markers of endothelial dysfunction in children with renal pathology
Authors: Yarovaya Darya V. , Bashkina Olga A. , Krasilova Elena V.
Published: May 2023

Coronavirus infection (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2) RNA virus, has become a global problem in the world. Its consequences are of great importance for the health status of both adults and children, since the number of lethal outcomes and life-threatening complications has reached high rates. Of particular importance is coronavirus damage of important organs in childhood, due to the possible impairment of their functions and the development of later distant complications. Thus, the formation of acute kidney injury (AKI) in children is an independent risk factor for hospital mortality and disability. An important role in the development of this pathological condition is given to the development of endothelial dysfunction due to the activation of a number of pro-inflammatory cytokines and other biomarkers of endothelial disorders. Endothelitis, endothelial injury, endothelial cell dysfunction, and impaired microcirculatory function in various vascular beds all contribute markedly to life-threatening complications of COVID-19 such as venous thromboembolism and multiple organ failure. Endothelial dysfunction is the main determinant of microvascular disorders due to a shift in vascular balance towards greater vasoconstriction and subsequent organ ischemia, inflammation with concomitant tissue edema and procoagulant condition. In general, understanding the mechanisms of endothelial activation and dysfunction during COVID-19 infection can contribute to early detection of individuals, especially children, at risk of severe complications. Further study of endothelial dysfunction in the pathogenesis of AKI in children with COVID-19 is promising to determine a personalized approach to the management of pediatric patients with COVID-19.
Peculiarities of heavy metal and arsenic trans-medium transition along the chain "soil - medicinal plant material - water etracts"
Authors: Dyakova Nina A.
Published: May 2023

Low-quality herbal raw materials and the products obtained from them are important sources of various ecotoxicants, especially heavy metals, entering the human body. Aqueous extractions of medicinal plant raw materials - decoctions and infusions - are of a particular interest in this respect - as they are the most accessible and frequently used dosage forms in medical and pharmaceutical practice and traditional medicine, being at present insufficiently studied as sources of intake of various microelements in the human body. Objective: to investigate the peculiarities of heavy metals and arsenic trans-mediated transition along the chain "soil - medicinal plant raw materials - infusions and decoctions". Materials and methods. Raw materials were harvested during the flowering period in Voronezh Biosphere Reserve. The microelement composition of the samples was studied by mass spectroscopy on an ELAN-DRC device. Results. The content of toxic microelements estimated in medicinal plant raw materials of natural phytocenosis of Voronezh region does not exceed the pharmacopoeial requirements, and their total proportion in the total mineral complex - not more than 0.011%. All made infusions and decoctions from the studied raw materials infusions and decoctions also corresponded to pharmacopoeial requirements on the content of normalized elements. The efficiency of cadmium transfer in infusions and decoctions from medicinal plant raw materials ranged from 9.02% to 55.00%, arsenic - from 26.33% to 68.46%, lead - from 1.95% to 76.15%. In the chain "soil - medicinal plant material - water extracts" normalized elements in LRS to the greatest extent migrated to the decoction of burdock root: cadmium - 74.91%, arsenic - 13.98%, lead - 6.02%. The lowest degree of transition was noted for the infusion of the studied flowers: for cadmium - 4.78%, arsenic - 0.46%, lead - 0.73%. Conclusion. The findings are of great interest and may serve both for further research and for using in medical and pharmaceutical practice.
A Psicologia Educacional no âmbito da pós-graduação em Educação
Authors: Ribeiro Cynara Teixeira , Dos Reis Gusmão Andrade Erika
Published: May 2023

O debate acerca da inserção social e internacionalização justifica-se pelo fato de que estes são indicadores adotados pela CAPES para a avaliação dos programas de pós-graduação. Nosso objetivo é analisar em que medida os trabalhos apresentados pelo GT 20 – Psicologia da Educação da ANPEd (2011 a 2020) permitem evidenciar o compromisso com a inserção social e a internacionalização na produção de conhecimento nesta área. Foram consideradas quatro dimensões de análise apontadas pela literatura para cada indicador. Consideramos sessenta trabalhos, dos quais só 6,66% explicitam o atendimento a demandas sociais circunstanciadas. A maioria dialoga com a produção internacional, havendo, no entanto, pouca parceria entre autores que visam à construção de redes de conhecimento, além da prevalência de autores da Região Sudeste. A alta incidência de trabalhos publicados posteriormente, como artigos em periódicos, contraria a afirmação de que as publicações da área se concentram em livros.
Total Synthesis of Xestodecalactone C via Sharpless Epoxidation and
Friedal-Crafts Acylation
Authors: Sudhakar Chithaluri , Prasad Kottolla Sai , Ramesh Batharaju
Published: May 2023

Marine-derived macrolides that occur naturally exhibit a range of biological properties, including
antibacterial and antifungal activity.

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Sharpless epoxidation and intramolecular acylation via the Friedel-Crafts method for the macrolide
ring formation was used as the main steps in the regioselective construction of naturally existing xestodecalactone
C, which was started from chiral propylene oxide.

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The isolated yellow coloured final product had a 91% yield, and FT-IR, Mass, 1H-NMR, and 13C
NMR were used to characterise each product. As a result, chiral propylene oxide was used as the starting
material for the regioselective total synthesis of the naturally occurring xestrodecalactone C, with
the main stages being intramolecular Friedel-Crafts acylation for macrolide ring formation and Sharpless
epoxidation. The synthesis of numerous xestrodecalactone C analogues relevant for bioevaluation
can be done quickly and easily using this synthetic approach.
Evaluating the Potential of Green Light Exposure on Nociception-A Mini
Review
Authors: Qaiser Hammad , Uzair Mohammad , Arshad Muhammad , Zafar Anessa , Bashir Shahid
Published: May 2023

The capacity of animals to react to unpleasant stimuli that might endanger their integrity is
known as nociception. Pharmacological treatments do not show satisfactory results in response to nociception.
In the recent era, light therapy emerged as a potential non-pharmacological approach for
treating various diseases, including seasonal affective disorders, migraine, pain, and others. Evaluating
the potential of green light exposure on nociception involves studying its effects on different types of
pain and pain-related conditions and determining the optimal exposure methods. This review provides
the beneficial effects of green light on the reduction in the frequency of pain. The green light exposure
on nociception changes the activity of pain-related genes and proteins in cells. This review could provide
insights into the underlying mechanisms by which green light modulates pain. Overall, evaluating
the potential of green light exposure on nociception requires a multidisciplinary approach and should
consider the safety, efficacy, optimal dose, and duration of green light exposure and the type of pain.
However, few studies have been reported so far; therefore, light therapy for treating migraines require
more studies on animal models to provide precise results of light effects on nociception.
Research on financial autonomy and financial management in public higher education
Authors: Hong Le Thi Thu
Published: May 2023

This article examines financial autonomy and management in public higher education, focusing on its definition, significance, key factors, benefits, and challenges. It emphasizes the importance of institutions' control over their financial resources, with factors such as revenue diversification, efficient resource allocation, strategic partnerships, and performance-based funding contributing to financial autonomy. The article discusses the benefits of financial autonomy, including increased flexibility, entrepreneurial culture, and financial sustainability, while also addressing challenges like tuition affordability, marketization concerns, and accountability issues. It explores financial resource management through budgeting, resource allocation, cost control, transparency, and revenue generation. The methods and tools for financial management encompass financial planning, performance metrics, cost analysis, risk management, and technology utilization. The article concludes by offering recommendations for Vietnam, such as strengthening financial planning, diversifying revenue sources, enhancing accountability and transparency, adopting technology, and promoting collaboration. Overall, it provides valuable insights for policymakers and institutions to effectively manage financial resources and ensure the sustainability and quality of public higher education.
ANÁLISE INSTITUCIONAL DE DIREITO E ECONOMIA
Authors: Mueller Bernardo
Published: May 2023

Nas últimas duas décadas a Economia passou por uma guinda empírica. Teoria econômica e modelos matemáticos, que antes dominavam em termo de publicações e atenção, foram ultrapassados por análises focadas em métodos de inferência causal calcados na exploração de variação exógena e randomização para estabelecer relações causais entre variáveis. Essa mudança coevoluiu com a realização da importância das instituições em análises econômicas. A Nova Economia das Instituições, que há muito tempo vinha enfatizando a importância central de instituições foi incorporada ao maistream da Economia, pois a randomização necessária para estabelecer relações causais muitas vezes depende de detalhes institucionais. No entanto, apesar da nova atenção sobre instituições, muitas vezes elas são tratadas de maneira superficial ou simplificada. Neste artigo eu descrevo em maior detalhe dois conceitos centrais da Nova Economia das Instituições; direitos de propriedade e custos de transação. Juntos, esses conceitos formam a base do Teorema de Coase que é o ponto de partida tanto da Nova Economia das Instituições, como da Economia dos Custos de Transação, como da literatura de Direito e Economia.
Adsorption of Phosphate by Synthesized Silver/Calcium Oxide-Activated Carbon Nanocomposite
Authors: Nyakairu George William , Ntale Muhammad , Usman Mariam Onize
Published: May 2023

Developing adsorbents with appreciable morphology will create new approaches for better phosphate adsorption performance. This study aims to investigate the design of an adsorbent by impregnating silver nanoparticles (AgNPs) onto calcium oxide-activated carbon (CaO-AC). The Ag/CaO-AC nanocomposite was used as an adsorbent to remove phosphate. Batch adsorption studies were performed to evaluate the effects of adsorbent dose, initial phosphate concentration, contact time, and pH on removing phosphate from an aqueous solution. The optimized conditions were applied to a real wastewater sample. The optimum condition for phosphate adsorption on Ag/CaO-AC nanocomposite was at an adsorbent dose of 0.02 g, an initial phosphate concentration of 40 mg∙L-1, an equilibrium contact time of 45 minutes, and pH 7. Pseudo-second-order proved to be more accurate in representing the data of phosphate adsorption onto Ag/CaO-AC nanocomposite. The adsorption isotherm fitted well on the Langmuir model with a maximum adsorption capacity of 77.4 mg∙g-1. From the kinetics and isotherm studies, chemisorption was the primary adsorption mechanism through ion exchange and ligand exchange mechanisms. The results of this study show that Ag/CaO-AC nanocomposite is a promising adsorbent for removing phosphate from wastewater.
Successful Kidney Transplantation of Two Patients with Donors Positive for Severe Acute Respiratory Syndrome Coronavirus Infection
Authors: Gama Rouvick M , Phanish Mysore , Ghazanfar Abbas , Banerjee Debasish
Published: May 2023

Despite preventative measures, including vaccination, severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection may result in severe illness, particularly in immunosuppressed transplant recipients. This has had a negative impact on organ donation and transplantation rates. However, the risk of transmission from SARS-CoV-2 positive donors to kidney transplant recipients is unknown. We describe 2 cases of successful kidney transplantation from SARS-CoV-2 positive donors. Case 1: 38-year old unvaccinated female, established on haemodialysis for 1 year, with underlying reflux nephropathy. Donor tested SARS-CoV-2 positive on polymerase chain reaction testing with a cycle threshold (CT) value of 29 initially. Sequential testing demonstrated a rise in CT value (37.8), aiding the decision to proceed. The recipient was high immunological risk and received a controlled category 3 donation after circulatory death (DCD) kidney transplant. She had immediate graft function and did not develop SARS-CoV-2 infection. Case 2: 63-year old female, with diabetes mellitus and hypertension. She was low immunological risk and for pre-emptive transplantation. The donor was SARS-CoV-2 positive with a CT value of 41.5 and was subsequently negative. Decision was made to proceed with a donation after brainstem death (DBD) transplant. The recipient had immediate graft function and did not develop SARS-CoV-2 infection. We report 2 cases of successful transplantation from SARS-CoV-2 positive donors, without severe infection, with no transmission seen in the recipients post-operatively. Decisions to proceed were primarily made on clinical grounds with assistance from RT-PCR CT values, making this a useful additional tool in determining suitability of organ donation in people who are SARS-CoV-2 positive.
Determinasi Tingkat Kemiskinan di Sumatera Selatan Tahun 2019-2022
Authors: Mirrahma Aliyah Aisyiyah , Septiani Msy Aziza , Panorama Maya
Published: May 2023

Poverty is a multidimensional problem related to economic, political, social, cultural, and community participation. This is evidenced by the increasing trend of the number of people living below the poverty line. The main trigger of poverty in Indonesia is the inequality of economic distribution or what is known as economic justice. Whereas all religions prohibit economic monopoly actions that cause injustice and order their people to give charity (zakat) and cooperate evenly. With the aim of reducing the poverty rate of the community even though we still often hear of hunger and hardship for some humans. This means that the welfare that is expected and aspired to has not been realized for people's lives. According to BPS 2022 data, South Sumatra is included in the top 10 with high poverty rates. Therefore, this study aims to determine, explain and analyze the factors that affect the Percentage of Poor Population (PPM) in South Sumatra for the period 2019-2022. This research method uses panel data regression method with individual unit observations as many as 17 districts / cities of South Sumatra province in a four-year period from 2019 to 2022. This study uses one response variable, namely PPM and four explanatory variables, namely the unemployment rate (TPT), average years of schooling (RLS), GRDP per capita, and human development index (HDI). The results of this study show that the fixed effect model with two-way specific effects is the best model of the panel data poverty rate. Variables that have a significant effect are GRDP. RLS. and HDI
Conformación de comités regionales: herramientas de apoyo según experiencia Vichada
Authors: Rodríguez Castañeda Catalina , Fernanda Azabache Luisa , Anzueta Puerta Karen Lizeth Castro Mercado, Manuel Eduardo Ostos Triana , Espitia Maldonado Erika , Castro Mercado Lizeth , Ostos Triana Manuel Eduardo
Published: May 2023

Cada día las abejas van de flor en flor en busca de néctar y polen para llevar a su colmena. Labor que se distingue por su organización y efectividad. A nivel mundial la producción de miel es cercana a 1 millón 800 mil toneladas (Faostat 2018). China se posiciona como el principal productor (447.000 toneladas), seguido por Turquía (108.000 toneladas) y Argentina (79.000 toneladas), que por su extensión geográfica y población han logrado imponer escalas de producción significativas. El presente documento da a conocer la ruta para la conformación de los comités regionales e incluye tres herramientas que permiten encaminarla. Al final se encuentra la ruta recorrida por el departamento de Vichada.