bluuebunny/crossref_metadata_2025 huggingface dataset:
Solitary Fibrofolliculoma of the Upper Eyelid in a 68-year Old Female: A Case Report
Authors: Wang Wenqiu , Cheng Jinwei
Published: April 2019

Background

Fibrofolliculoma is a benign, perifollicular, connective tissue tumor, which is a clinically asymptomatic, 2-4 mm, skin-colored, dome-shaped smooth papule. It usually arises in the form of multiple lesions, and very rarely presents as a solitary lesion.

Case presentation

A 68-year-old female presented with an asymptomatic, flesh-colored mass on the right upper eyelid. The 5×5×4 mm lesion was located near upper lid margin. It was a skin-colored, dome-shaped, smooth nodule, with eyelashes on the surface, rubbery to palpation and not painful. The lesion was excised completely, and the diagnosis of fibrofolliculoma was confirmed through a histological exam.

Conclusions

Solitary fibrofolliculomas is rarely arising in the eyelid. However, it should be suspected when a localized mass lesion of the eyelid is encountered.
Frameworks para el desarrollo de prototipos WEB: Un caso de aplicación
Authors: Gil Vera Víctor Daniel , Gomes Da Silva Claudio Rogério , Gil Vera Juan Carlos , Teutsch Jule
Published: April 2019

Los frameworks para el desarrollo de aplicaciones web facilitan el trabajo de desarrollares y profesionales de la industria informática. Actividades que requieren conocimientos y técnicas avanzadas de programación pueden realizarse con facilidad y en poco tiempo, suprimiendo la tediosa y repetitiva tarea asociada con patrones comunes de desarrollo web. Este trabajo tiene como objetivo presentar un caso de aplicación sobre el desarrollo e implementación de un prototipo web innovador que maneja el dominio de los cursos y docentes del Departamento de Ciencias de la Computación y la Decisión de la Facultad de Minas - Universidad Nacional de Colombia, Medellín, con programación orientada a objetos en PHP. Se presentan los aspectos innovadores del mismo y la justificación del por qué debería ser utilizado y no otros. Este trabajo concluye que, el uso de frameworks ayuda a disminuir errores de invalidez y permiten que los desarrolladores puedan centrarse en la escritura de su aplicación.
Guía para la configuración de la Interfaz Nativa de Java
Authors: Moreno Espino Mailyn , Bacallao Leiva Yilian , Ramos Guerra Raymel
Published: April 2019

En la actualidad existen diversos lenguajes de programación y es necesario contar con una herramienta que permita la integración entre ellos. Java provee de un framework llamado: interfaz nativa de Java, JNI por sus siglas en inglés; para permitir que se puedan escribir programas en otros lenguajes diferentes a Java y mantener la portabilidad entre todas las plataformas. Permite que el código que se ejecuta en la máquina virtual de Java pueda interactuar con aplicaciones y bibliotecas escritas en otros lenguajes, como C, C++ y ensamblador. Esta guía se basa en un ejemplo básico de una aplicación “Hello Word”, la cual servirá para de manera sencilla, mostrar los pasos a seguir para la configuración de JNI en los entornos de desarrollo involucrados, que para esta guía se utilizó, para Java: Eclipse y para C++: Visual Studio 2010.
La gamificación como estrategia didáctica para la enseñanza/aprendizaje de la programación: un mapeo sistemático de literatura
Authors: Revelo Sánchez Oscar , Collazos Ordoñez Cesar Alberto , Jiménez Toledo Javier Alejandro
Published: April 2019

La incorporación de la gamificación en cursos de Programación ha sido identificada como una estrategia potencial que podría maximizar la participación de los estudiantes y tener un impacto positivo en el aprendizaje. Hasta donde sabemos, no existe un estudio dirigido a recopilar y analizar los resultados de investigación sobre este tema utilizando un método sistemático. Para llenar este vacío, se realizó un mapeo sistemático de literatura con el objetivo de resumir los estudios sobre el uso de la gamificación como estrategia didáctica para la enseñanza/aprendizaje de la Programación. Inicialmente, mediante la búsqueda en cuatro (4) bibliotecas digitales, se obtuvieron 186 estudios. Luego, después de un cuidadoso análisis de cada uno de ellos, verificamos que sólo 78 coinciden con nuestras necesidades. Por último, hemos categorizdo las contribuciones de estos estudios para presentar una visión general de los resultados producidos por la comunidad investigadora.
Tendencias en el desarrollo social y económico en relación al transporte aéreo, aerotrópolis
Authors: Correa Escobar Juan Felipe
Published: April 2019

La sociedad que conocemos, es el fruto de la interacción del hombre con el entorno, donde sus recursos y la forma de aprovecharlos, de transformar la naturaleza y establecer lazos con otras comunidades termina por perfilar el desarrollo, la economía, la cultura y un sinfín de características que han creado un orden mundial.
Dos perspectivas acerca del concepto de contracultura: marginalidad y diversidad
Authors: Betancur Arias Juan Diego
Published: April 2019

Una parte del mundo occidental es hoy caracterizada por políticas, pueblos, personas, sociedades, religiones, economías, escuelas de pensamiento y pensadores ligeros o lights. Las latitudes que componen este segmento de la realidad están permeadas por lógicas inmediatistas, no contemplativas, aceleradas, denigrantes y desgastantes, que utilizan al ser humano para que sea el artífice de la construcción, pero también de la destrucción; son tiempos en los que se gestan emociones negativas en la mentalidad de los seres humanos, aflorando los execrables flagelos del ámbito social como: el feminicidio, el viricidio, el suicidio, la autoflagelación, los abusos sexuales, los familicidios, los homicidios, la drogadicción, el alcoholismo, la contaminación ambiental, entre otros. Los seres humanos sumergidos en estas lógicas destructivas de pensamiento, emoción y comportamiento se alejan cada vez más rápido de la identificación cultural; son más los malestares subjetivos que causa en ellos estar en estos contextos éticos y participativos a nivel social, que terminan siendo depredadores de la tranquilidad y armonía del otro. Su construcción identitaria, como grupos marginales, es fuera de la norma, atípica y antisocial. Esta concepción de contracultura establece patrones comprensivos que permiten el entendimiento de otras posibilidades en la alteridad, aunque estas, vistas desde una perspectiva humana y sensible, sean extremadamente salvajes y reptilianas
¿Identidad verdadera o idealizada? Proyección de la identidad en Facebook
Authors: Araque Lotero Yuly Milena , Tirado Mejia Yuliana , Taborda Yepes Katherin Yesenia , Garcia Castaño Vanessa , Millan Otero Katy Luz
Published: April 2019

Las redes sociales, especialmente Facebook, han cobrado importancia en la vida de los jóvenes, convirtiéndose en una herramienta fundamental en la cotidianidad. Esta investigación buscó comprender la proyección de la identidad de los jóvenes de 20 a 25 años en la red social Facebook, pertenecientes a estratos bajos y altos de la ciudad de Medellín. La investigación es cualitativa, con enfoque fenomenológico, para la que se utilizaron la entrevista semiestructurada y la colcha de retazos como técnicas de observación. Los resultados destacan que los jóvenes de estratos altos están en constante búsqueda de popularidad, mientras que los de estratos bajos se interesan más por la interacción con sus pares; el contenido que ambos hacen público es verídico, y da cuenta de la influencia de sus amigos en aquello que quieren proyectar de sí mismos y en la construcción de su identidad. Se concluye que los jóvenes publican contenidos de acuerdo con los intereses propios y del círculo en el que se desenvuelven, en busca de popularidad (estratos altos) o relacionarse con sus pares (estratos bajos), además, no cambian o modifican aspectos de su vida y hacen notoria la influencia de los amigos en aquello que muestran en la red social.
La experiencia de formación en intervención terapéutica: reflexiones suscitadas durante el entrenamiento de la Especialización en Terapia Familiar de la Universidad Católica Luis Amigó
Authors: Archbold Correa Gintay , Arias Zapata Viviana Marcela , Fernández Vélez Erica Evidalia , Florez Gómez Ana Maria , González Muñoz Edwin Eliecer , González Vergara Aura Milena , Duque Lopera Andrea Lopera , Marin Toledo Daniela , Monsalve Tamayo Maria Camila , Ospina Jaramillo Diana Johanna , Pulgarín Jaramillo Astrid Elena , Ruiz Correa Kelly Alejandra , Toro Bedoya Eunice , Alvarez Carmin Vidal
Published: April 2019

El presente artículo plantea reflexiones resultado de la experiencia de entrenamiento en intervención terapéutica con familias, llevada a cabo durante el primer semestre de formación como especialistas en terapia familiar de la Universidad Católica Luis Amigó. En el ejercicio se identifican asuntos significativos como la comprensión del sí mismo (self), la comunicación como posibilidad, el uso de técnicas y la experiencia de observación en las primeras sesiones con familias. Al plantear reflexiones suscitadas durante la práctica de entrenamiento, se retoman elementos conceptuales y vivenciales que articulados se consideran eje central del terapeuta familiar que busca conducir el ejercicio profesional bajo una epistemología sistémica con asiento conceptual y un verdadero proceso reflexivo.
La internacionalización: un acercamiento al crecimiento empresarial
Authors: Yepes Baena Natally , Quintero Arango Luis Fernando
Published: April 2019

Actualmente, las organizaciones enfrentan una seria amenaza de sostenibilidad en un mercado local competitivo, como consecuencia de los cambios que ha presentado la economía mundial tras el paso de los años; esto ha exigido el desarrollo de estrategias innovadoras como mecanismos de crecimiento empresarial. El presente artículo de revisión teórica pretende abordar la estrategia de internacionalización por parte de las empresas como factor clave de crecimiento y, a su vez, evidenciar importantes elementos que la condicionan.
¿Cómo el comunicador puede ser mediador a través de la narrativa digital?
Authors: Gomez Oviedo Elva Emilia , Ruiz Jesenia
Published: April 2019

Las plataformas digitales han cambiado la forma de comunicarse, permitiendo un fácil acceso a cualquier tipo de información. Actualmente, la difusión de mensajes se da de una manera rápida e interactiva, donde miles de usuarios están conectados diariamente consumiendo nuevos contenidos acordes con sus necesidades y gustos. Por tal motivo es importante que el comunicador sea un mediador para crear contenidos digitales con una esencia cultural que permita el fomento de la misma. En consecuencia, es importante que conozca las plataformas digitales que actualmente se utilizan y las características que las componen, para que pueda transmitir mensajes efectivos con una usabilidad favorable. Otro requisito importante que debe cumplir el mediador es conocer el lenguaje utilizado en la sociedad en la cual va a comunicar, para que se dé una cercanía entre emisor y receptor, y así se generen cambios comunicativos.
Añoranzas
Authors: Betancur Arias Juan Diego
Published: April 2019

Cuento corto para ilustrar las involuciones y la falta de consciencia social y personal en el ser humano.
Possibility of using dabigatran in patients with atrial fibrillation and acute coronary syndrome and PCI
Authors: Erlich A. D.
Published: April 2019

This article is devoted to the problem of combined antithrombotic therapy in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) due to acute coronary syndrome (ACS). Traditionally, these patients require an oral anticoagulant (OAC) to prevent stroke and dual anti-platelet therapy (DAT) to prevent coronary complications. The necessity of combining various antithrombotic drugs, since this greatly increases the risk of bleeding is becoming an increasing relevant clinical problem. The prolonged triple therapy in the form of a combination of OAC and DAT does not bring additional benefit to the patients, but, on the contrary, may be potentially dangerous. Currently, the possibility of using several new oral anticoagulants (NOAC) in patients with AF and ACS/PCI in the form of dual therapy has been proven: combination of OAC and p2Y12 inhibitor. The article focuses on the RE-DUAL PCI study, in which the use of dabigatran at both doses permitted in AF (150 mg twice daily and 110 mg twice daily) in combination with the p2Y12 inhibitor was associated with fewer bleeding complications than during the triple therapy in the form of OAK + DAT.

The article presents a clinical case of the possibility of management of a patient with AF and ACS under the modern clinical guidelines, as well as an overview of current guidelines for the use of OAC and DAT in patients with AF undergoing PCI.
Possibilities of using Fosinopril, an angiotensinconverting enzyme inhibitor, combined with Diltiazem, a non-dihydropyridine calcium antagonist, as first-line therapy in the treatment of arterial hypertension (clinical case)
Authors: Ostroumova O. D. , Goloborodova I. V.
Published: April 2019

The article exemplified the successful experience of using combination therapy consisting of fosinopril, an angiotensin-converting enzyme inhibitor, and diltiazem, a non-dihydropyridine calcium antagonist, in a patient with a history of arterial hypertension, sinus tachycardia and bronchial asthma. The authors proved the high antihypertensive efficacy and safety of the therapy, its favourable effect on the daily profile of blood pressure and heart rate, and strong organ-protective properties, the ability to reduce the degree of left ventricular hypertrophy and microalbuminuria level.
Direct oral anticoagulants: first airbag
Authors: Sokolova A. N. , Skripka A. I.
Published: April 2019

The safety profile of oral anticoagulants (DOACs) was confirmed in the large-scale studies, the increased risk of hemorrhagic events does still exist, which may be caused by the nature of the patient’s concomitant pathology, the resulting injury or the need for emergency surgical procedures. Such measures to restore the coagulation cascade as the use of prothrombin complex concentrates or hemodialysis have not been widely used in the clinical practice to stop the anti-coagulant effect of DOACs and do not have an evidence base. Today, idarutsizumab (Praxbind) is the only specific antagonist to DOACs registered in the Russian Federation, a neutralizing agent that interacts with free and thrombin-related dabigatran, without affecting other blood coagulation factors and platelet function. RE-VERSE AD study showed that administration of idarucizumab in patients receiving dabigatran therapy and who developed life-threatening bleeding provided complete neutralization of the anti-coagulant effect of dabigatran for 4 hours, and after 1.5 hours emergency surgical treatment was performed, achieving at the same time, normal perioperative hemostasis in 93.4% of cases. The availability of a specific neutralizing agent for a specific DOAC could be identified as arguments in favour of choosing this drug for patients who have a high risk of a hemorrhagic event, emergency surgery or thrombolysis.
Magnesium and female reproductive system
Authors: Nazarenko E. G.
Published: April 2019

The article emphasizes the role of magnesium in a woman’s body, the causes and symptoms of its deficiency. It also describes the role of estrogens, combined oral contraceptives and hormone replacement therapy in the development of magnesium-deficient states, and the relationship between these states and vitamin B6. The paper overviews multicenter studies on the treatment of magnesiumdeficient conditions from the standpoint of evidence-based medicine, which show the need to maintain an adequate level of magnesium  and pyridoxine in the treatment of estrogen-dependent diseases.
HPV and HPV-associated cervical diseases in women, who use hormonal methods of contraception: diagnostic and treatment management of abnormal cytology test result
Authors: Nazarova N. M. , Gusakov K. I. , Sycheva E. G.
Published: April 2019

If abnormal cytology test results are identified in the users of hormonal methods of contraception, including a vaginal ring, they should adhere to diagnostic algorithms aimed at identifying and treating HPV-associated cervical diseases. NovaRing vaginal ring is an effective, reliable and safe method of hormonal contraception, including for women who have previously undergone surgical treatment of HSIL.
HPV-associated diseases in women and men: principles for diagnosis, treatment, prevention
Authors: Nazarova N. M. , Pavlovich S. V. , Attoeva D. I.
Published: April 2019

Human papillomavirus infection in women and men causes benign, premalignant and malignant diseases of the anogenital area. Laboratory diagnosis plays a major role in early detection of HPV-associated diseases in women, but there are no approved screening modalities, which can detect HPV-associated diseases in men. Examination of the sexual partners of patients with anogenital HPV diseases is a substantiated and important link in a chain of cancer prevention methods.
Therapy of urinary tract infections in gynecological practice
Authors: Balushkina A. A. , Kan N. E. , Tyutyunnik V. L.
Published: April 2019

The urinary tract infection continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy reproductive women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial urinary tract infection. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental investigation.
Modeling of the problem of the fuel metering unit functioning
Authors: Denisova E.V. , Nasibullaeva E.Sh.
Published: April 2019

In the paper, a dynamic model of the fuel metering unit (FMU) functioning is considered numerically, which includes three moving elements (servo piston, throttle needle and constant-drop valve). Numerical calculations showed that the characteristics of FMU as an element of the automatic control system are nonlinear and inhomogeneous, and that cavitation regimes may arise in the cavities of FMU.
Axisymmetric flow near the critical point on the moving boundary
Authors: Nasibullayev I.Sh. , Nasibullaeva E.Sh.
Published: April 2019

In this paper the investigation of the axisymmetric flow of a liquid with a boundary perpendicular to the flow is considered. Analytical equations are derived for the radial and axial velocity and pressure components of fluid flow in a pipe of finite length with a movable right boundary, and boundary conditions on the moving boundary are also defined. A numerical solution of the problem on a finite-difference grid by the iterative Newton-Raphson method for various velocities of the boundary motion is obtained.
Inhibitors of DNA Methylation and Histone Deacetylation as Epigenetically Active Drugs for Anticancer Therapy
Authors: Myasoedova Veronika A. , Sukhorukov Vasily , Grechko Andrey V. , Zhang Dongwei , Romanenko Elena , Orekhov Vawain , Orekhov Alexander N.
Published: April 2019

Gene expression is regulated and tightly controlled by epigenetic mechanisms. Alterations of these mechanisms are frequently observed in various diseases, particularly, in various types of cancer. Malignant transformation is caused by the impairment of the mechanisms of cell differentiation and cell cycle control associated with epigenetic changes. Altered patterns of epigenetic modification associated with malignancies can potentially be reversed by some agents that act on the key proteins responsible for DNA/histone modification and chromatin remodelling. Examples of such substances include the inhibitors of DNA methyltransferases or histone deacetylase. During the recent years, a number of such substances have been evaluated as potential therapeutic agents against certain types of cancer in preclinical and clinical studies, and some of them have been approved for treatment of hematological cancers. Application of epidrugs for therapy of solid tumors remains, however, more challenging. In this review, we summarize the current knowledge on the most studied mechanisms of epigenetic modification and the available epigenetically active drugs.
Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells
Authors: Skonieczna Magdalena , Hudy Dorota , Poterala-Hejmo Aleksandra , Hejmo Tomasz , Buldak Rafal J. , Dziedzic Arkadiusz
Published: April 2019

Background:

Levels of cellular Reactive Oxygen Species (ROS) influence the oxidized/reduced
states of cellular proteins, and create redox-signaling pathways that can activate transcription factors, kinases,
and phosphatases. ROS levels can be increased radically by external factors, including ionizing and UV radiation or
exposure to chemical compounds. These increased ROS levels can, in turn, lead to oxidative damage of DNA.
Natural plant treatments against cancer can modulate these processes by inducing or decreasing ROS production.

Methods:

Here we report new observations that squamous carcinoma (SCC-25) cells, exposed to 24 hours of
combined resveratrol and berberine treatment, contain increased ROS levels. Using flow cytometry, for drug
activity characteristics, an accumulation of ROS was observed. A combination of different dyes, CellROX
Green (Life Technologies) and DCFH-DA (Sigma), allowed for flow cytometric estimation of levels of cellular
ROS as well as cellular localization.

Results:

Live staining and microscopic observations confirmed the accumulation of ROS in SCC-25 cells following
a combination treatment at concentrations of 10μg/ml. Additionally, the cytotoxicity of the compounds
was significantly improved after their combined application. Additive effects were observed for doses lower
than the calculated IC50 of berberine [IC50=23µg/ml] and resveratrol [IC50=9µg/ml]. Viability (MTS) assays and
analysis of isobolograms revealed a significant impact on cell viability upon combination treatment.

Conclusion:

These results suggest that administration of berberine, in the presence of resveratrol, could be
decreased even to 50% (half the IC50 for berberine) for cancer treatment.
Phycocyanin Extracted from Oscillatoria minima Shows Antimicrobial, Algicidal, and Antiradical Activities: In silico and In vitro Analysis
Authors: Venugopal Vaishali C. , Thakur Abhimanyu , Chennabasappa Latha K. , Mishra Gaurav , Singh Kunal , Rathee Parth , Ranjan Anjali
Published: April 2019

Background:

Phycocyanin is an algae-derived protein, which binds to pigment for harvesting light. It has been reported in various different species, including that of red algae, dinoflagellates, and cryptophyta. Importantly, phycocyanin has enormous applications, including cosmetic colorant, food additive, biotechnology, diagnostics, fluorescence detection probe, an anticancer agent, anti-inflammatory, immune enhancer, etc. In addition, several different algae were utilized for the isolation of cyano-phycocyanin (C-PC), but most of the purification methods consist of several steps of crude extraction.

Aim:

To isolate C-PC from a new source of microalgae with better purity level and to evaluate its antimicrobial, algicidal, and antiradical activities.

Methods:

Biological activity, permeability, pharmacokinetics, and toxicity profile of C-PC were predicted by in silico studies. C-PC was purified and isolated by using ammonium sulphate precipitation, ion-exchange chromatography and gel-filtration chromatography. C-PC was characterized by SDS-PAGE and elution profile (purity ratio) analysis. Antimicrobial and algicial activities of C-PC were evaluated by the microtitre plate based assays. Antiradical activity of C-PC was evaluated by DPPH- and ABTS*+ radical scavenging assays.

Conclusion:

C-PC was extracted from Oscillatoria minima for the first time, followed by its quantitative as well qualitative evaluation, indicating a new alternative source of this important protein. Furthermore, the antimicrobial, algicidal, and antiradical activities of the isolated C-PC extract have been demonstrated by both in silico as well as in vitro methods.
Should the Argument About Aspirin Dosing be About Frequency Rather the Dose?
Authors: Norgard Nicholas B. , Jain Priya , Enriquez Jonathon R.
Published: April 2019

Aspirin is known to have inter-individual variability in its pharmacodynamic
response. Clinical investigators continue their empirical search for the optimum aspirin
dose to safely prevent athero-thrombosis. Several patient populations have an
accompanied accelerated platelet turnover that is associated with a time-dependent loss
of aspirin efficacy. Increasing the dosing frequency has been shown to elicit better and
more sustained platelet inhibition compared to a dose increase in these patient populations.
This review explores the role of accelerated platelet turnover in aspirin
pharmacodynamics and the benefits of multiple daily aspirin dosing
Diminishing Effects After Recurrent Use of Self-Guided Internet-Based Interventions in Depression: Randomized Controlled Trial (Preprint)
Authors: Bücker Lara , Schnakenberg Patricia , Karyotaki Eirini , Moritz Steffen , Westermann Stefan
Published: April 2019

BACKGROUND

Self-guided internet-based interventions have several advantages over guided interventions and are generally effective in treating psychiatric symptoms.

OBJECTIVE

We aimed to investigate whether the use of a new self-guided internet-based intervention (MOOD) would lead to a significant reduction in depressive symptoms compared with a care-as-usual (CAU) control group in a sample of individuals with depressive symptoms, most of whom had already used a different self-guided internet-based intervention in a previous trial.

METHODS

A total of 125 individuals were randomized to the intervention condition (MOOD) and received access to the intervention for a period of six weeks or a CAU group. After six weeks, all participants were invited to take part in the post assessment. The Beck Depression Inventory-II served as the primary outcome.

RESULTS

Both intention-to-treat as well as per-protocol analyses indicated that the depressive symptomatology decreased in both conditions but showed no advantage for those who had used MOOD. Subsequent moderation analyses suggested that those individuals who had less experience with psychotherapy benefitted to a greater extent compared with those with more experience.

CONCLUSIONS

Self-guided internet-based interventions are deemed a suitable first-step approach to the treatment of depression. However, our results indicate that they are more efficacious in those with less psychotherapy experience.

CLINICALTRIAL

ClinicalTrials.gov NCT03795480; http://clinicaltrials.gov/ct2/show/NCT03795480
Leachate Treatment with a combined Fenton/filtration/adsorption processes
Authors: Méndez Novelo Roger Iván , May Marrufo Armín Alejandro , San Pedro Cedillo Liliana , Rojas Valencia María Neftalí , Giácoman Vallejos Germán
Published: April 2019

Fenton and adsorption are two of the most widely used physicochemical processes for leachates treatment. Each one separately has shown limited treatment capabilities, reaching COD removals up to 60-70%. The Fenton process oxidizes both organic and inorganic matter; nevertheless, low-density sludges are produced and hard to decant. To remove them, the filtration process could be an efficient alternative to eliminate these solids the remaining substances could be removed by means of the adsorption process. This study presents the results of a Fenton/filtration/adsorption treatment train, under the following conditions: a) Fenton: pH = 4, contact time= 60 minutes, [Fe2+]/[H2O2] = 0.6, [COD]/[H2O2] = 9; b) leachate filtered through 4 µm pore filter paper; c) adsorption was performed in a packed column with macroporous granular activated carbon. The COD removals reached 99.9%, where 90.8% was achieved with the Fenton/filtration process and 9.1% was removed by adsorption. The 95.7% of color was removed in the Fenton/filtration stage and 4.3% by adsorption. Although, the COD, BOD5, color and TSS removals from the adsorption process were lower than the Fenton/filtration process, the additional removal allows to the effluent reach the values required to meet the current Mexican Norms
PROBLEM OF LANGUAGE REDUNDANCY ON THE EXAMPLE OF A SCIENTIFIC TEXT
Authors: Alontseva Natalia V , Ermoshin Yury A
Published: April 2019

Language redundancy is an actual problem for native Russian speakers. In this article, the authors consider the issue of linguistic redundancy in written communication, and describe some of its aspects using examples derived from various scientific and popular-scientific articles in the field of humanities (psychology, linguistics, literary criticism) selected from public Internet sources. The article describes the history of the scientific study of the problem of linguistic redundancy in texts of various styles, presents a typology of examples of linguistic redundancy primarily at the level of a combination of lexical units and at the level of text construction. The research also gives arguments on the reasons for linguistic redundancy emergence and possible steps to overcome it. The object of the study is a popular-scientific and scientific text, the subject of the study are stylistic errors and elements of language redundancy. The material of the analysis is represented in the texts obtained by the method of continuous sampling from collections of scientific articles in the Russian language, posted on the Internet. In each specific example, the authors propose their own way of expressing content without unnecessary lexical units, omitting or replacing them with synonyms and synonymous expressions. The stylistic error causing the problem of linguistic redundancy is a violation of the formal connection of sentences in the text, in which the reference words or link words are repeated. The article provides their typology and examples of errors of this type. The scientific novelty of the research is primarily related to the lack of research on linguistic redundancy on the material of scientific texts In Russian. The authors of the article see the practical value and possible implementation of the results in the drawing attention of the authors of scientific texts to their works in terms of their compliance with the norm in this aspect.
FORMATION OF PROFESSIONAL (LINGVOCULTURAL) COMPETENCE OF ITALIAN STUDENTS0CULTUROLOGISTS
Authors: Persiyanova Svetlana G , Rostova Evgeniya G
Published: April 2019

The article deals with the problem of the formation of the professional (linguistic and cultural) competence of Italian students-culturologists, specializing in the study of Russian culture in its synchronic and diachronic examination. The authors offer a description and analysis of the program implemented by the Pushkin State Russian Language Institute together with the Milan State University. The program includes courses: “History of Russian Culture”, “Modern Russian Literature”, “Language and Culture”. The article focuses on the original course “Language and Culture”, which is part of the program, based on an analysis of the peculiarities of the connection between the Russian language and culture in different historical periods, which fundamentally distinguishes it from traditional language and culture courses. The article describes the features of the structure and content of the course “Language and Culture” for students-culturologists, its goals, tasks and methodological apparatus. The course includes five thematic sections: “The Language and Culture of Ancient Russia”, “The Russian Language and Culture of the 18th Century”, “The Russian Language and Culture of the 19th Century”, “The Russian Language and Culture of the 20th Century”. The main goal of the course is to deepen students’ knowledge of the relationship between the Russian language and culture (in the interaction of diachronic and synchronous components), the development of their communicative competence, mainly in the socio-cultural sphere of communication associated with the future professional activities of the culturologist. An important component of the training in this course is the Multimedia language and culture Dictionary “Russia”, which is publicly available on the Pushkin State Russian Language Institute portal. The dictionary materials (articles, media library, interactive tasks) form the main content of the course.
FROM SYSTEMIC LINGUISTICS TO SYNTHESIS WITH OTHER FIELDS OF KNOWLEDGE
Authors: Maslova Valentina A , Lavitski Anton A
Published: April 2019

The article shows that G.P. Melnikov’s scientific heritage is still of great importance in the 21th century. As a prominent thinker of the 20th century he both deepened the concept of the systematic nature of the language by creating an evolutionary approach to the problem and laid the foundation for the holistic picture of the world, the development of integrative approach and made it clear that the range of research tools had to be widened. His works support the ideas revealed when the potent directions of modern linguistics are considered in detail in terms of including anthropological, sociological and psychological aspects of language space and language picture of the world into research. To a certain extent G.P. Melnikov’s works supplement the developing theories of integrativeness and transfer, synergies and other.
THE SYNTAX OF NOVEL FIGURATIVE NAMES IN RUSSIAN AND ENGLISH: TYPOLOGICAL ASPECT
Authors: Kiose Maria I
Published: April 2019

The study reveals the syntactic features of novel figurative names and nominal constructions in texts in application to typologically different Russian and English languages. The data obtained helped to clarify the role of predication in salience enhancement, which encompasses novel figurative names construal. We conducted the two-staged contrastive analysis, which allowed to detect several specific parameters and synchronization means demonstrating the typological diversity of the two languages. As it is the salience that serves as one of the basic factors of successful reference identification in terms of implicitness and figurativeness, the research results will play a role in explaining why indirect names are interpreted differently. At the first stage we applied the statistical analysis to detect typologically relevant characteristics of syntactic positioning in terms of novel figurative names and nominal constructions. At the second stage we developed the procedure of 54 and 56 parameter correlation analysis to synchronize the lexical, syntactic and narrative parameters with figurative names in subject and predicate positions. These correlations revealed a group of parameters activated in the English language and restricted in Russian. The subject salience parameters involve the use of substantiated attribute in pre-position, sentence final position with predicate in pre-position. The predicate salience parameters were hybrid morphological character of predicate indirect names, explicit exteroception in pre-position or in the name itself, characterizing focus of indirect names (metaphoric transfer). At the same type due to syntactically salient predicate position such indirect names could allow non-agentive event role and orthographic non-markedness.
Medical-Legal Partnerships to Enhance Residency Training in Advance Care Planning
Authors: Pettit Jessie M. , Ryan Anne M. , Armin Julie , Weiss Barry D.
Published: April 2019

Background and Objectives: Only about one-third of adult Americans have completed advance directives for end-of-life care, and primary care physicians report that they are not always comfortable discussing advance care planning (ACP) with patients. Current approaches to teaching clinicians about ACP have limited evidence of effectiveness. With the objective of improving residents’ comfort and skill discussing ACP with patients, we developed a curriculum that involved clinicians and attorneys working together to teach first-year family medicine residents (R1) about leading ACP discussions with patients.
Methods: Our curriculum consisted of a 1-hour multimedia training session on ACP followed by a series of direct in-exam room observations. Attorney and/or physician faculty observed residents holding ACP discussions with patients and provided structured feedback to residents about their performance. The initial R1 cohort observed had a series of three direct observations; the subsequent R1 cohort had two direct observations. We developed an evaluation tool with a 5-point developmental scale (beginner, novice, developing, near mastery, mastery) corresponding to the Accreditation Council for Graduate Medical Education’s milestone system to score residents’ performance.
Results: R1 performance improved from the beginner/novice level during the first observed ACP discussion to the novice/developing level during the second or third discussion, representing an increase in competence to that expected of a second- or early third-year resident.
Conclusion: Based on our initial experience, using medical-legal partnerships to teach residents about ACP may be more effective than previously reported approaches. Validation of our results with a larger sample is needed.
En søken etter en utvidet fysisk tolkning av vokal samtidsmusikk og av opera
Authors: Silje Marie Aker Johnsen
Published: April 2019

"En søken etter en utvidet fysisk tolkning av vokal samtidsmusikk og av opera" er Silje Aker Johnsens kunstneriske doktorgradsarbeid ved Operahøgskolen, Kunsthøgskolen i Oslo.

Det kunstneriske doktorgradsarbeidet fokuserer på kombinasjonen av bevegelse og vokalutøvelse i forskjellige sammenhenger og i ulike uttrykk. Silje Aker Johnsen har bakgrunn fra det klassiske musikkfeltet, opera og samtidsmusikk, men også som danser og i tverrkunstnerisk scenekunst.

Hovedlinjene i prosjektet følger prosesser og refleksjoner rundt material- og verkutvikling og den tverrfaglige utøverens potensielle roller i ulike utviklingssituasjoner. Refleksjonsarbeidet diskuterer ulike plasseringer i sjangere, grader av medskapende virksomhet, aspekter av forberedelse, trening og improvisasjon i utviklingen av en praksis.

Disposisjonen beskriver, og reflekterer rundt, prosessene i hovedverkene i prosjektet:
Her
av Erik Dæhlin og Silje Aker Johnsen.
Dette verket har gått som en rød tråd gjennom doktorgradsarbeidet og blitt bearbeidet og vist i flere versjoner. "Her" er også en del av komponist og regissør Erik Dæhlins kunstneriske doktorgradsarbeid ved Norges Musikkhøgskole, "Shared Space - mot en relasjonell, prosessuell og intermedial kompositorisk praksis."
Her, KHiO, 2017
Her, Scene 2, Den Norske Opera og Ballett, 2018
Her, utdrag, KHiO, 2018, som en del av Aker Johnsens avsluttende presentasjon av sitt doktorgradsarbeid, forestillingen "En søken.. "

I forestillingen "En søken…" arbeidet Aker Johnsen med tre ulike samarbeidspartnere og innganger til sammenføyningen av vokalutøvelse og bevegelse: I tillegg til samarbeidet med komponist og regissør Erik Dæhlin, inkluderte dette et verk i samarbeid med koreograf Mia Habib og en adapsjon av et koreografisk partitur av Janne-Camilla Lyster:

Sedimenter
av Mia Habib og Silje Aker Johnsen

Tulipan
Koreografisk partitur av Janne-Camilla Lyster, Adapsjon av Silje Aker Johnsen

Opera:
Ballerina
kammeropera, av komponist Synne Skouen, librettist Oda Radoor og regissør Hilde Andersen, er blant hovedverkene innen opera. Operaen ble bestilt av Den Norske Opera og Ballett og oppført ved Den Norske Opera og Ballett i 2017.

Disposisjonen benytter en kombinasjon av ulike tekster og videorefleksjoner, samt videodokumentasjon av utvalgte verk, til å kommunisere refleksjonsarbeidet.
Structure, dielectric and electrical properties of relaxor lead-free double perovskite: Nd2NiMnO6
Authors: Das Rutuparna , Choudhary Ram
Published: April 2019

In this paper, dielectric relaxor, impedance, AC conductivity and electrical
modulus of double perovskite Nd2NiMnO6, prepared by a solid state reaction
method and sintered at 1250?C, have been reported in the wide temperature
(25-150?C) and frequency (1 kHz-1MHz) ranges. From the preliminary X-ray
structural analysis, it is found that the structure of the material is
monoclinic. In the study of the temperature dependence of the dielectric
constant, the relaxor behaviour of the material is observed. Such type of
behaviour is explained by a modified Curie-Weiss and a Vogel-Fulcher law. By
analysing Nyquist plots, the existence of grain and grain boundary effects
is established. The non-Debye type of relaxation is investigated by the
analysis of complex impedance and the modulus data. From the study of
impedance data, it is found that the grain resistance is reduced with the
increase in temperature indicating the existence of negative temperature
coefficient of resistance (NTCR) behaviour in the material which also
matches with temperature versus AC conductivity plots. From these results,
it may be concluded that this compound may have extreme potential for
different high temperature applications.
Mechanochemical synthesis and consolidation of nanostructured cerium hexaboride
Authors: Ağaoğulları Duygu , Balcı Özge , Akçamlı Nazlı , Suryanarayana Challapalli , Duman İsmail , Öveçoğlu Mustafa
Published: April 2019

This study reports on the mechanochemical synthesis (MCS) and consolidation
of nanostructured CeB6 powders of high purity. CeB6 powders were prepared
via MCS by milling CeO2, B2O3 and Mg powders in a high-energy ball mill for
different milling times. The effects of milling time on the formation,
microstructure and thermal behaviour of the synthesized powders were
investigated and the optimum MCS duration was determined. Purified powders
were obtained after HCl leaching by removing MgO by-product. The prepared
powders were characterized by a number of techniques including X-ray
diffraction, stereomicroscopy, scanning and transmission electron microscopy
coupled with energy dispersive spectrometry, differential scanning
calorimetry, atomic absorption spectrometry, particle size analysis, surface
area analysis and vibrating sample magnetometry. The high-purity CeB6
powders having an average particle size of 86 nm were consolidated by
cold-pressing followed by pressureless sintering at 1700 ?C for 5 h. The
bulk CeB6 specimen was investigated for its microstructure, density,
electrical resistivity, surface roughness and some mechanical properties
(microhardness and wear behaviour). The relative density, electrical
resistivity, microhardness and wear rate of the bulk CeB6 were determined as
95.2%TD, 57.50 ?W?cm, 11.65GPa and 1.46 ? 10?4 mm3/N?m, respectively.
Influence of low-temperature reaction time on morphology and phase composition of short calcium phosphate whiskers
Authors: Biernat Monika , Jaegermann Zbigniew , Tymowicz-Grzyb Paulina , Konopka Gustaw
Published: April 2019

The present work shows the results of the synthesis of multiphasic calcium
phosphate whiskers from a mixture of biphasic calcium phosphate
(?-tricalcium phosphate (?-TCP) and calcium pyrophosphate (CPP)) in the
hydrogen peroxide solution-mediated process carried out in different time
ranges. The process was performed at considerably lower temperature than
typical hydrothermal methods used for obtaining of whiskers. Test results
show that using the above-mentioned procedure triphasic calcium phosphate
consisting of hydroxyapatite (HA),(?-TCP) and CPP can be obtained, where
the whiskers are formed mainly from hydroxyapatite. It was found that
morphology, phase composition and specific surface area of the reaction
product can be controlled by changing the reaction time. The obtained
triphasic HA/?-TCP/CPP short whiskers may be considered as a promising
biocompatible and resorbable reinforcement in composites for bone tissue
engineering with a faster resorption rate than that of HA.
Bioactive glass 58S prepared using an innovation sol-gel process
Authors: Bui Xuan , Dang Tan
Published: April 2019

A 58S bioglass with a composition in the ternary system 58SiO2-33CaO-9P2O5
(wt.%) was prepared by an innovation sol-gel process in which a small amount
of ammonia was used to facilitate the condensation reactions within an
acidic solution prepared by tetraethyl orthosilicate, triethyl phosphate and
calcium nitrate tetrahydrate. The properties of synthetic glass were
investigated by several techniques. The amorphous nature and high specific
surface area (99.1m2/g) of the obtained glass were confirmed by using X-ray
diffraction and low-temperature nitrogen adsorption techniques,
respectively. In vitro experiments were performed by soaking glass samples
in the simulated body fluid (SBF). The XRD patterns and SEM images confirmed
the bioactivity of the synthesized bioglass by formation of a dense and
visible hydroxyapatite layer on its surface after 2 days of in vitro assays.
The ICP-OES data illustrated the ion exchange behaviours between the
bioglass 58S and the SBF solution.
Effect of Conventional and Acid-modified Casein Phosphopeptide-Amorphous Calcium Phosphate Crèmes on Dentin Permeability Before and After Acid Challenge
Authors: Kijsamanmith K , Banomyong D , Burrow MF , Kanchanasantikul P , Wipawiwat S , Srikam S , Laojarungphesatchakorn S
Published: April 2019

This study investigated the effect of conventional and acidified casein phosphopeptide-amorphous calcium phosphate–containing crèmes (CPP-ACP and ACPP-ACP) on dentin permeability (DP) before and after acid challenge, using a fluid-flow measuring device and scanning electron microscopic (SEM) examination. Fifty dentin discs were prepared from intact human third molars. Each tooth was sectioned 3 mm above and below the cementoenamel junction. The smear layer was removed to expose the dentin and dentinal tubules. For fluid-flow measurement, 20 specimens were used and divided into two groups: (a) CPP-ACP (pH=7) and (b) ACPP-ACP (pH=2). The dentin surfaces were treated with the crème for five minutes daily for two weeks, and then an acid challenge was performed using 6% citric acid. Under simulated pulpal pressure, DP was measured at baseline, five minutes, two weeks, and after acid challenge. The remaining specimens were prepared and examined using SEM to investigate dentinal tubule occlusion. DP was not significantly different between the two CPP-ACP–containing crèmes at any test period (p≥0.05). DP after two weeks or acid challenge was significantly lower than that at five minutes (p<0.05). The results were consistent with the SEM micrographs that presented patent dentinal tubules after a five-minute application and partial blockage of dentinal tubules after the two-week application. The dentinal tubules remained partially occluded after acid challenge. Using conventional and acid-modified CPP-ACP–containing crèmes for two weeks decreased DP and partially occluded the dentinal tubules, which resisted acid challenge.