bluuebunny/crossref_metadata_2025 huggingface dataset:
Weight Loss and Therapeutic Metabolic Effects of Tetrahydrocannabivarin (THCV)-Infused Mucoadhesive Strips
Authors: Smith Gregory
Published: May 2024

Objective: Metabolic syndrome is due to dysregulation that starts with fat accumulation, causing inflammatory response, insulin resistance, dyslipidemia, hypertension, and fatty liver disease. The endocannabinoid system, via cannabinoid receptor type 1 (CB1), has been shown to be involved with energy homeostasis and regulation of appetitive behavior via activity in the hypothalamus, limbic forebrain and amygdala and in the peripheral tissues including adipose, liver and muscle. Therefore, two phytocannabinoids, tetrahydrocannabivarin (THCV), a CB1 neutral antagonist, and cannabidiol (CBD), a negative allosteric modulator of CB1, are expected to have therapeutic metabolic benefits, including weight loss. Method: A placebo-controlled study was conducted on 44 subjects (31 females and 13 males) with an average age of 51.75. The study evaluated the efficacy of two different doses of THCV and CBD (8 mg THCV/10 mg CBD in the lower dose and 16 mg THCV/20 mg CBD in the higher dose), taken once daily for 90 days via mucoadhesive oral strips, for weight loss and improvement of certain metabolic markers. Results: Use of the THCV/CBD strip was associated with statistically significant weight loss, decreases in abdominal girth, systolic blood pressure, and total and LDL cholesterol. The study was limited by small sample sizes in both the high dose and placebo groups. Conclusions: The 16 mg/20 mg daily dose was superior for weight loss compared to the 8 mg/10 mg daily dose; both sets of results differed from placebo in a way that was statistically significant. The results of this study were congruent with the prior unpublished studies of a hemp extract containing significant percentages of THCV, CBDV and CBD.
Emergence and spread of a mupirocin-resistant variant of the European epidemic fusidic acid-resistant impetigo clone of Staphylococcus aureus, Belgium, 2013 to 2023
Authors: Yin Nicolas , Michel Charlotte , Makki Nadia , Deplano Ariane , Milis Alisha , Prevost Benoit , Miendje-Deyi Veronique Yvette , Hallin Marie , Martiny Delphine
Published: May 2024

Background

Antimicrobial resistance to mupirocin and fusidic acid, which are used for treatment of skin infections caused by Staphylococcus aureus, is of concern.

Aim

To investigate resistance to fusidic acid and mupirocin in meticillin-susceptible S. aureus (MSSA) from community-acquired skin and soft tissue infections (SSTIs) in Belgium.

Methods

We collected 2013–2023 data on fusidic acid and mupirocin resistance in SSTI-associated MSSA from two large Belgian laboratories. Resistant MSSA isolates sent to the Belgian Staphylococci Reference Centre were spa-typed and analysed for the presence of the eta and etb virulence genes and the mupA resistance gene. In addition, we whole genome sequenced MSSA isolates collected between October 2021 and September 2023.

Results

Mupirocin resistance increased between 2013 and 2023 from 0.5-1.5% to 1.7-5.6%. Between 2018 and 2023, 91.4% (64/70) of mupirocin-resistant isolates were co-resistant to fusidic acid. By September 2023, between 8.9% (15/168) and 10.1% (11/109) of children isolates from the two laboratories were co-resistant. Of the 33 sequenced isolates, 29 were sequence type 121, clonal and more distantly related to the European epidemic fusidic acid-resistant impetigo clone (EEFIC) observed in Belgium in 2020. These isolates carried the mupA and fusB genes conferring resistance to mupirocin and fusidic acid, respectively, and the eta and etb virulence genes.

Conclusion

We highlight the spread of a mupirocin-resistant EEFIC in children, with a seasonal trend for the third quarter of the year. This is of concern because this variant is resistant to the two main topical antibiotics used to treat impetigo in Belgium.
Applying Machine Learning to Survey Question Assessment
Authors: Yan Ting , Sun Hanyu , Battalahalli Anil
Published: May 2024

Sun and Yan (2023) described a Computer-Assisted Recorded Interviewing (CARI) Machine Learning (ML) pipeline that efficiently processes 100% of recorded interviews as quickly as possible and as inexpensively as possible. The CARI ML pipeline leads to automatic identification of recordings that are at a higher risk of being falsified or exhibiting undesirable interviewer behaviors. This paper describes an extension to the pipeline that can be used to automatically detect survey questions at a higher risk of poor performance. A proof-of-concept study was conducted and showed that the enhanced pipeline was able to detect worst performing items judged by experts. The results demonstrated the potential of the enhanced pipeline to screen and select problematic items for conventional behavior coding and to improve the efficiency of using CARI for question evaluation and testing.
Factors that Influence the Offender’s Decision MSME’s Have a Halal Certificate in the District Bogor
Authors: Izzah Hanifah Nurul , Irfany Mohammad Iqbal
Published: May 2024

Based on Law No. 33 of 2014, the government requires halal certificates for food or drinks circulating throughout Indonesia, including those produced by MSMEs, the majority of business actors in Indonesia. Only 1 percent of MSMEs have halal certificates in Indonesia. This research aims to analyze the factors that influence the decision of MSMEs in Bogor Regency to have a halal certificate. The method used in this research is descriptive analysis and multiple linear regression analysis. This research uses primary data from 50 respondents who were interviewed via questionnaire. The results of this research show that the branding variable has a positive influence on the decision of MSMEs to have a halal certificate. The variables of halal awareness, regulations and halal certification facilities do not influence the decision of MSMEs to have a halal certificate.
Estimating Groundwater Level in Peatlands by Using Submersible Sensor
Authors: Putra Erianto Indra , Syakbandani Muhammad Uqbah El , Pramono Sigit , Saad Asmadi
Published: May 2024

Peatland fires pose a significant challenge in peatland management, with declining groundwater levels being a contributing factor. Real-time monitoring of groundwater levels (GWL) is essential to address this issue effectively. This study examines GWL data collected from submersible sensors and manual readings in peatlands of Tangkit Baru and Pematang Rahim villages, Jambi Province. Results reveal an increase in GWL in Tangkit Baru coinciding with rising precipitation, while Pematang Rahim experiences a contrasting decrease despite heavy rainfall. Statistical analysis, specifically t-tests, indicates no significant difference (p > 0.05) between the two measurement methods. However, slight discrepancies (0.1-1 cm) between submersible sensor and manual measurements underscore the importance of sensor maintenance for accurate GWL assessment.
Keywords: Peatlands, sensors, groundwater level
ACESSO UNIVERSAL A MEDICAMENTOS E SEU PAPEL NA REALIZAÇÃO DO DIREITO HUMANO À SAÚDE
Authors: FERREIRA ALLAN BERTHIER SILVA , SILVA CÁSSIA MARA ALEXANDRINO , SOUSA MIRNA RIBEIRO FREITAS DE , DINIZ JÉSSICA MARIA GABRIELA DA SILVA , SANTOS THAYNAN DE SOUZA , OLIVEIRA AMANDA RODRIGUES MENDES DE , COSTA MAYSA SILVA CASTELAR , RIBEIRO NAYARA FERNANDA AMORIM MADEIROS , CAVALCANTE FLÁVIA MARIA SILVA , VIDAL RAISSIANA ANDRADE
Published: May 2024

Analisar os impactos do acesso universal a medicamentos e seu papel na realização do
direito humano à saúde. Trata-se de uma revisão integrativa da literatura em que a
construção da pesquisa está amparada na questão: "Qual é o impacto do acesso universal
a medicamentos na promoção e realização do direito humano à saúde?" A coleta de dados
ocorreu por meio da consulta às bases de dados LILACS, SciELO, MEDLINE e BDENF
utilizando os descritores “Direito à Saúde” AND “Direitos Humanos” AND
“Medicamentos”. O acesso universal a medicamentos desempenha um papel fundamental
na promoção e realização do direito humano à saúde, garantindo igualdade de acesso aos
tratamentos necessários, reduzindo disparidades e melhorando a qualidade de vida. Isso
não apenas contribui para a saúde e bem-estar da população, mas também é um
componente essencial dos direitos humanos à saúde, fortalecendo políticas públicas e
programas governamentais que ampliam o alcance dos serviços de saúde e beneficiam
especialmente os grupos socioeconomicamente menos favorecidos. O acesso universal a
medicamentos é essencial para garantir a equidade no sistema de saúde e promover a
realização do direito humano à saúde, destacando a importância de políticas públicas
eficazes para ampliar esse acesso e beneficiar toda a população.
Palavras-chave: Direito à Saúde; Direitos Humanos; Medicamentos; População; Saúde
Pública.
OS IMPACTOS DAS DIFICULDADES MOTORAS NAS OCUPAÇÕES DA PESSOA COM DEFICIÊNCIA INTELECTUAL
Authors: Sá Nonato Márcio Custódio Maia , Santana Ingrid Estheffani Calil , Mendes Michely Caroline Nascimento , Mello Nathalia Castilhos , Batista Paula Rayane Oliveira
Published: May 2024

Ao longo dos anos, o conceito de Deficiência Intelectual (DI)
passou por diversas modificações, sendo denominado por várias terminologias, como oligofrenia, retardo mental e deficiência mental. Após a realização da Conferência Internacional sobre Deficiência Intelectual, em 2001, no Canadá, a pedido da International Association for the Scientific Study of Intellectual Disabilities (IASSID), esta terminologia, “deficiência intelectual”, tornou-se oficialmente adotada, inclusive no Brasil, para se referir às pessoas anteriormente classificadas como tendo “deficiência mental” (Duarte, 2018).
Alcohol Use and Deaf and Hard of Hearing College Students
Authors: Gannon Christine , Gibble Theresa Hunter , Evans Retta
Published: May 2024

Alcohol misuse on college campuses has been shown to be the cause of physical, socio-emotional, and academic harms. Alcohol is also an issue at Gallaudet University but there is a gap in the literature describing this phenomenon. Using the social ecological model, this qualitative case study explored student perceptions and experiences with alcohol use through interviews with 24 deaf and hard of hearing college students at Gallaudet University. The main themes included: something to do, isolation, coping, communication, “playing catch up with life,” belonging, peer pressure, and university dynamics. The results of this study supported the research on alcohol use in the college environment, showing these themes to also be true at Gallaudet University. As a result, researchers recommend for Gallaudet University and other institutions use the education and interventions shown to be effective in the College Alcohol Intervention Matrix with deaf and hard of hearing students. Researchers also identified themes that were divergent from general college students and specific to the experience of being deaf and hard of hearing. This study highlighted the interpersonal level impact and importance of communication with alcohol and related harms. Researchers recommend further research on the spectrum of communication isolation on alcohol use, related harms, and the social-ecological impact of these experiences. In addition, researchers recommend programming and services to specifically address the issues that occur as a result of isolation, coping challenges, desire to belong, susceptibility to peer pressure, and wanting to catch up on life. It is hoped that the insights gained from this study will be used to inform interventions for deaf and hard of hearing college students, to reduce alcohol misuse, and thus to impact positive change.
Environmental sustainability practices: A systematic literature review
Authors: Tennakoon W. D. N. M. S. , Janadari M. P. N. , Wattuhewa I. D.
Published: May 2024

This systematic literature review explores the evolution and significance of environmental sustainability practices from 2010 to 2023. Through this exploration, we aim to uncover discernible patterns, emerging trends, and valuable insights that shed light on the trajectory of these practices and their far-reaching consequences for environmental conservation and sustainable development. The review highlights the growing awareness of ecological sustainability by using a four-step technique to select 351 papers. Our key findings underscore the critical role of multidisciplinary collaboration, data-driven decision-making, and adaptive management strategies in advancing environmental sustainability practices. Notably, technological advancements in data collection, analysis, and modeling, such as remote sensing, satellite technology, and citizen science initiatives, have substantially enhanced the efficacy of these practices. Furthermore, shifts in governmental frameworks and international agreements, such as the Paris Agreement and the Convention on Biological Diversity, have profoundly influenced the trajectory of environmental sustainability practices. This review serves as a valuable tool for comprehending the evolution and impact of environmental sustainability initiatives, offering insights that can inform policy decisions, future research, and practical applications toward fostering a more sustainable and harmonious coexistence with our planet.
La memoria viva de la calle: impactos sociales, culturales y políticos en Chile
Authors: Doran Marie-Christine , Peñafiel Ricardo
Published: May 2024

Este artículo argumenta que existe en Chile un proceso específi co de cons-trucción social de la memoria, que, en un contexto institucional adverso, no solo ema-na de las agrupaciones especializadas, sino que también de una apropiación social de los temas de la memoria y de los derechos humanos por parte de diversos movimientos sociales. Mediante un análisis plurisemiótico del discurso, realizado a partir de un ma-terial de consignas de manifestaciones y entrevistas a defensores de derechos humanos, se analizan diferentes ejes de construcción social de la memoria, cuya expresión pública –en las calles– culmina con el estallido de 2019. Este análisis permite demostrar que la construcción social de memoria en Chile debe ser califi cada como contrahegemónica por su cuestionamiento al modelo chileno postdictatorial en su conjunto, al provocar un cambio de la lengua política característica de la postdictadura y su narrativa de acusación a las víctimas, la cual asociaba el conflicto social a la ruptura democrática y defendía la amnistía como condición de la reconciliación y de la estabilidad del llama-do modelo chileno.
Niños y niñas transgénero: desafíos para su inclusión en comunidades educativas
Authors: Álvarez Díaz Andrea , Montenegro González Catalina
Published: May 2024

En este trabajo se refl exiona acerca de las posibilidades y límites que tene-mos como comunidades y agentes educativos en Chile para enfrentar el desafío ético y político de incluir a niños y niñas transgénero en un espacio escolar “inclusivo”. El foco del análisis se sitúa en la comunidad educativa, en sus actores y acciones instituciona-les, entendiendo que un proceso de transición de género trae consigo una oportunidad de cambio y aprendizaje para las familias y colectivos a los cuales se vincula. A partir de una revisión bibliográfi ca, se describe el contexto educativo chileno en el que la infancia trans se enfrenta a violencias físicas, psicológicas y simbólicas que vulneran sus derechos y su dignidad. Revisamos estrategias educativas de inclusión, algunas cer-canas a la asimilación, otras más orientadas a la integración, mientras otras logran pau-latinamente instalar procesos inclusivos que cuestionan la heteronorma como disposi-tivo político de opresión de sexo/género. Se proponen recomendaciones pedagógicas e institucionales para evitar que la infancia transgénero quede supeditada a estrategias de inclusión que la subalternizan, planifi cadas y diseñadas desde la lógica heterosexual.
Mujeres campesinas y cocina tradicional: consolidación del saber culinario en la provincia de Lengupá - departamento de Boyacá, Colombia
Authors: Bernal Monroy Diana Marcela , Alvarado Reyes Nidian Giovanna
Published: May 2024

En la provincia de Lengupá - departamento de Boyacá, la cocina tradicional y las mujeres campesinas consolidan un saber culinario producto de los sincretismos culturales de las zonas andinas y llaneras. En dicho contexto se elabora esta investi-gación, cuyo objetivo es analizar el papel fundamental desempeñado por las mujeres campesinas en el proceso de elaboración de alimentos, específicamente en su contribu-ción signifi cativa a la consolidación y enriquecimiento del saber culinario a partir del conocimiento del territorio, los ofi cios y la relación con la naturaleza. Por medio del uso de entrevistas se abordaron las prácticas culinarias a través de lecturas, experien-cias y recuerdos personales de las cocineras. Los resultados indican que el saber culi-nario se consolida gracias al papel que cumplen las mujeres no solo en la preparación de los alimentos, sino en el conocimiento estacional de los mismos. Además, cobra especial relevancia el reconocimiento que comienzan a tener las mujeres dentro de la cocina desde perspectivas de salvaguardia del ofi cio tradicional, identidad e iniciativas de productividad y economía solidaria en el territorio.
Representaciones del trabajo social en la prensa digital mexicana
Authors: Rodríguez Otero Luis Manuel , Mancinas Espinoza Sandra Elizabet
Published: May 2024

La prensa es un medio de socialización para orientar actitudes mentales y promover la sensibilización social. Se planteó una investigación con el objetivo de analizar las publicaciones sobre trabajo social en la prensa digital mexicana. Se realizó un estudio mixto descriptivo, no experimental y transversal. A partir de un universo de 14 diarios de tirada nacional en México se seleccionaron 372 noticias y se realizó un análisis hemerográfi co diacrónico. Los resultados revelaron que a pesar de que los me-dios de comunicación tienen un papel determinante en la construcción del imaginario social del trabajo social y de la socialización de sus funciones, las acciones y los progra-mas que desarrolla, la prensa mexicana apenas visibiliza la profesión e incluso contri-buye a la estereotipación de esta. Por otro lado, se observa que la perspectiva ideológica de los periódicos y el sexo de los y las periodistas infl uyen en el encuadre de las noticias, la visibilidad y el tipo de imagen que se difunde sobre el trabajo social. Concluimos que la representación del trabajo social que realiza la prensa digital mexicana asume imágenes multiformes, ambivalentes y difusas sobre su identidad, funciones, acciones y ámbitos de actuación.
MODERN APPROACHES TO THE IMPLEMENTATION OF A MARKETING SYSTEM FOR ANTI-CRISIS MANAGEMENT OF AGRICULTURAL ENTERPRISES
Authors: Bahorka Mariia , Pysarenko Volodymyr
Published: May 2024

The purpose of the article is to study the system methodology and situational approach to the study of the crisis state of an agricultural enterprise, to analyse the theory and practice of anti-crisis management, to improve the mechanism of adaptation of an agricultural enterprise to crisis phenomena, and to propose effective anti-crisis management tools. The methodological basis of the study was a synthesis of the results of applied research in economics, scientific works of domestic and foreign scientists, which highlighted the basic theories of competitive advantage, competitiveness and marketing management. Results. The results of the research together solve an important scientific and practical problem – the formation of a marketing system of anti-crisis management in the conditions of transformational economy. This system is strategic in nature and reflects the significant influence of social factors, risks and conditions of uncertainty. In the course of the study, a number of circumstances were identified that determine the negative and positive consequences of the crisis, as well as the conditions for overcoming it, without which it is difficult to objectively determine the probable losses and forecast possible options for the development of the enterprise. Practical results. To overcome the crisis, the company can take various measures, such as restructuring, financial reorganisation, strategic planning, changes in management structure, development of new products, marketing measures, etc. It is important to respond to the signs of the crisis in a timely manner and to manage the situation effectively in order to ensure the sustainable functioning of the company under difficult conditions. At the same time, the role of marketing activities in the anti-crisis management system is crucial. The task of marketing activities is to promote constant adaptation to changes in environmental factors and the company's operating conditions. Taking into account the modern development of the market economy, financial instability and the company's solvency, the effective organisation of a complex anti-crisis management system is of key importance. Value/Originality. Anti-crisis management is considered as a system of managerial actions and decisions in the conditions of transformation of the socio-economic system. These actions are aimed at diagnosis, prevention, elimination of crisis phenomena and neutralisation of their effects and consequences in the future.
KEYS TO CREATING AN EFFECTIVE REGIONAL INNOVATION INFRASTRUCTURE
Authors: Bodniia Ivan , Kerezvas Ivan , Syvochka Vasyl
Published: May 2024

Integration processes in science, education and production are driven by the acceleration of scientific and technological progress, the introduction of innovative scientific developments into mass production and the informatisation of the economy. The development of knowledge-intensive industries places new demands on the training and retraining of innovation-sensitive personnel, as well as on science, education and the economy as a whole, which are currently unable to develop effectively independently and adapt to changes in technology and engineering. The purpose of the article is to find promising areas for the development of education and science based on their integration with business entities not only within the limited space of regions, but also on the basis of spatial integration of territories with a special geographical location. Methodology. The necessary and socially significant conditions for the integration of science, education and business are the achievement of knowledge and skills, goals and values related to the acceleration of the reproduction of innovation potential in society, awareness of the role of science, education and business in solving problems of innovation development, and also their integration interaction in this area. Practical implications. Three main levels of economic systems are allocated: individual, organisation, and region. It has been determined that the degree of influence of innovation processes on them is determined by the presence and condition of three factors necessary for the formation of innovation susceptibility (stabilising, activating and structural). Value/Оriginality. Based on the concepts of the main innovation systems and the necessary conditions for innovative economic growth, the authors have clarified the content of the category "innovation receptivity of the region". The paper also reveals the basic principles of building a model of innovation receptivity and determines the degree of interdependence and interdependence between its constituent elements based on a systematic approach.
RESEARCH OF STUDENTS' ORIENTATIONS REGARDING INTERNATIONAL MIGRATION
Authors: Bulyk Oksana
Published: May 2024

The purpose of the article is to identify and compare the essential characteristics of migration attitudes among Ukrainian and Polish students, and to outline trends in their development in the future. Methodology. The subjects of the research are students of various courses and specialties of the Lviv National Environmental University and the University of Life Sciences in Lublin (Poland). To collect empirical information, an online survey was conducted in October 2023, with 187 Ukrainian and 187 Polish students (n=374) participating. The questionnaire consisted of 10 questions, the results of which will be analysed in this study. The survey results showed that students of both higher education institutions have a rather positive attitude towards international migration processes, both women and men. Possible manifestations of student mobility can be seen as a fact that characterises the social role of modern students. Practical implications. The work is a study of young people's attitudes to migration, i.e., it is prospective, not retrospective. Such research can be extremely useful for the development of an effective socio-economic policy of the country. Since the research results reflect the moods of young people, they cannot claim to be highly predictive. However, a vision of what might happen if people's hypothetical aspirations were to become reality can be a powerful argument for politicians and statesmen in developing migration-related policies, both now and in the future. Value/Originality. Survey data from different age groups of students at two universities allow for a better understanding of their attitudes towards migration, immigration, and mobility and a comparison of these indicators in a peaceful country and in times of war. Possible manifestations of student mobility should be seen as a fact that characterises the social role of modern students. The problem, however, is that there are currently no effective mechanisms for managing these processes. There are also no mechanisms capable of ensuring the systemic effectiveness of communication links between different actors at the intercultural level, with the possibility of meeting their socio-cultural, professional and material needs in the process of socialisation of modern youth, as well as for the adequate reproduction of the intellectual potential of society as a whole. However, student emigration cannot be viewed exclusively from a negative perspective, as a "brain drain", although it is obvious that if students who study and work abroad do not return, the country loses part of its intellectual potential (Adamic, Dyachuk, 2023; Tokar, 2022). If to consider the return and emigration not as a purely territorial movement of students, but as a movement of intellectual resources, one can identify a positive trend: significant intellectual potential in the form of ideas, technologies and professional knowledge is returning to the country.
Pengaruh Knowledge Self-Efficacy, Rewards terhadap Online Knowledge Sharing Behavior: dengan Dimoderasi oleh Organizational Innovation
Authors: Lozen Chelsea , Hosen Chandra
Published: May 2024

In the era of digitalization that is growing continuously, sharing knowledge online is one of the keys to developing innovation. Companies must also compete in increasing competitiveness because competition is getting tougher, so companies need to find ways to make company activities more effective and efficient in increasing innovation. One way is to implement online knowledge sharing, this research provides important understanding in understanding the factors that influence online knowledge sharing behavior such as knowledge self-efficacy, extrinsic and intrinsic rewards. This study uses a minimum sample of 45 samples from PT XYZ employees, but all 50 employees are willing to fill out statements in the questionnaire provided, this research uses a quantitative approach with a comparative causal research method and data collection is carried out through a questionnaire with Likert scale measurements distributed via Google Form. Then the researcher also conducted data analysis techniques using 2 tests, namely the outer model test and also the inner model using SmartPls 3 software. The results of this study indicate that the extrinsic reward variable has a significant effect on online knowledge sharing behavior, which means that the company has succeeded in implementing extrinsic rewards for employees in the implementation of online knowledge sharing. However, the variables of knowledge self-efficacy, intrinsic reward do not have a significant effect, employees also do not have sufficient self-efficacy to carry out knowledge sharing and the level of self-efficacy of employees is also not high in general, and employees feel that intrinsic rewards are not enough to motivate them to do online knowledge sharing, intrinsic rewards given by superiors or coworkers are also still insufficient, and organizational innovation does not have a strong influence in moderating all existing variables.
Pengaruh Service Quality, Store Atmosphere, dan Price Fairness terhadap Customer Satisfaction dan Customer Loyalty pada Haidilao Mall Taman Anggrek
Authors: Wijaya Haggi Setia
Published: May 2024

Every corporation or business entity operating in any field of business naturally aims to obtain profit. To achieve this goal, companies will pay attention to factors that can encourage customers to make purchases. This study aims to investigate the influence of Service Quality, Store Atmosphere, Price Fairness, Customer Satisfaction, and Customer Loyalty. The research gathered 126 samples through questionnaire distribution. It is a quantitative study of descriptive nature, employing a Likert scale for questionnaire measurement. Additionally, the researcher utilized data analysis techniques including two tests: outer model testing consisting of convergent validity, discriminant validity, and reliability testing, and inner model testing including R Square and path analysis significance testing using SmartPls 3 software. The findings indicate that Service Quality and Store Atmosphere significantly influence Customer Satisfaction, while Customer Satisfaction significantly affects Customer Loyalty. However, Price Fairness does not significantly influence Customer Satisfaction. Future research is encouraged to explore different objects, variables, and further theoretical discussions.
Analisis Jabatan Fungsional Pengelola Pengadaan Barangjasa pada Lingkungan Pemerintah
Authors: Ningrum Siti Kartinah , Herdiansyah Muhammad Izman
Published: May 2024

The purpose to be achieved in this study is to determine and analyze the implementation of the achievement of the functional position of goods and services procurement manager in the environment of South Sumatra Province. Key informants in this study were 7 people consisting of 5 Functional Officials of Goods and Services Procurement Managers and 2 structural officials. The analysis technique used is descriptive qualitative. The research results show that fulfilling the needs of the Functional Position of Goods and Services Procurement Manager has been supported by a good communication process, where changes in rules occur within a short period of time, thereby confusing the employees who are participants in the program. Apart from that, it has also been supported by reliable resources who have expertise in their fields, have a clear and measurable implementation time of 12 months and the availability of adequate facilities and infrastructure, for example computer facilities connected to the internet, printers and adequate space. In the disposition aspect, implementors and participants understand the aims and objectives of the policy program, especially implementation that prioritizes a sense of justice. Another factor is the bureaucratic structure that supports supervision and support from the executive and legislative parties.
Optimizing Customer Engagement: Employing Triangulation Methodology to Improve Social Media Content Strategy for MSME
Authors: Lady Lady , Shevia Shevia , Nurjanah Listia
Published: May 2024

 The internet offers great potential for the development of micro, small, and medium enterprises (MSMEs) in Indonesia. Nisa Kitchen, an MSME in Batam City specializing in making brownies, utilizes digital marketing and social media to grow their business. This is a qualitative research study aimed at exploring the effect of engaging social media marketing content on customer engagement, with a focus on Nisa Kitchen. In this study, researchers use methodological triangulation to gather data from various sources and perspectives. This technique allows for the validation of findings by combining different research approaches such as content analysis, interviews, and observations, thereby producing a deeper and more accurate understanding of the topic under investigation. In addition to the owner, the primary participants in this study are customers who have made purchases from Nisa Kitchen and are above 17 years old. The study aims to gain a comprehensive understanding of the implications for Nisa Kitchen. One of the challenges faced by MSMEs is a lack of understanding of technology and social media. This study emphasizes its unique contribution to the literature by presenting new insights and a comprehensive approach to enhancing customer engagement through attractive marketing content on social media. The study proposes solutions by creating useful and engaging content using Canva, Linktree, and WhatsApp Business to simplify customer access to Nisa Kitchen. The research findings indicate positive changes in social media insight data (engagement) and customer interviews.
PENGARUH EKSPOR NON MIGAS DAN INVESTASI LANGSUNG NETTO TERHADAP PDB NON MIGAS
Authors: Riza Fahrul
Published: May 2024

This paper measured the effect of export value from agricultural, mining, manufacturing and direct investment through the value of Indonesia’s non oil and gas Gross Domestic Product (GDP) from 2005 to 2013. By using ordinary least squre method, it showed that export from agricultural and minimg sector have significat effect to the value of non oil and gas Indonesia’s GDP. However export form manufacturing and direct investment didn’t show any significant effect
Keywords :
Non Oil and Gas Export, Investment Netto, Produk Domestik Bruto (PDB), Ordinary Least Square
Pengaruh Kualitas Layanan, Promosi, Citra Merek Terhadap Kesetiaan Pelanggan yang di Mediasi Kepuasan Pelanggan pada Dealer Mitsubishi Setia Kawan Motor Group
Authors: Law Tommy , Ihalauw John J.O.I.
Published: May 2024

Dalam memenangkan persaingan saat ini setiap perusahaan harus menciptakan dan mempertahankan kesetiaan pelanggan mereka sehingga perusahaan bisa terus berkembang. Terwujudnya kesetiaan pelanggan akan berdampak positif terhadap perusahaan karena pelanggan akan terus menggunakan produk dalam jangka waktu yang lama. Kesetiaan pelanggan dapat tumbuh disebabkan oleh kepuasan pelanggan. Kepuasan pelanggan dapat tercipta oleh beberapa faktor, antara lain adalah kualitas layanan, promosi, dan citra merek. Penelitian dilakukan dengan menyebarkan kuesioner kepada 200 responden di 5 Dealer Setia Kawan Motor Group. Metode penelitian ini menggunakan purposive sampling. Hipotesis penelitian diuji menggunakan Structural Equation Modeling (SEM). Pengolahan data menggunakan AMOS 22. Hasil penelitian ini menunjukkan bahwa kualitas layanan, promosi, dan citra merek berpengaruh positif dan signifikan terhadap kepuasan pelanggan. Kepuasan pelanggan berpengaruh positif dan signifikan terhadap kesetiaan pelanggan.

Kata kunci: Kesetiaan Pelanggan, Kepuasan Pelanggan, Kualitas Layanan, Promosi, Citra Merek.
Evaluación del riesgo hídrico en la cuenca del arroyo Napostá Grande (provincia de Buenos Aires, Argentina)
Authors: Mastrandrea Aldana , Angeles Guillermo Raúl
Published: May 2024

Los eventos hidrometeorológicos extremos han adquirido una creciente visibilidad en las agendas públicas durante las últimas décadas, dados los daños materiales que ocasionan y los grupos de población que resultan afectados, especialmente, aquellos que residen en las proximidades de los cursos/cuerpos de agua. El estudio de estos eventos, así como su distribución territorial, permite identificar sectores con diferentes niveles de criticidad ambiental. El objetivo de este trabajo es analizar las características del riesgo hídrico en el tramo inferior de la cuenca del arroyo Napostá Grande (Argentina). La metodología incluyó el análisis estadístico de datos climáticos, topográficos, biológicos y edáficos. Los resultados obtenidos demostraron que las áreas que presentaron un nivel de riesgo hídrico alto se ubicaron en sectores del noreste, noroeste, sur y sureste del área de estudio; en la categoría de riesgo hídrico medio se observó una gran superficie del espacio urbano mientras que las áreas que presentaron niveles bajos se localizaron mayormente en el sector norte y este. Esta información resulta clave para el diseño y elaboración de propuestas de planificación y ordenamiento territorial tendientes a reducir los potenciales daños ocasionados por la ocurrencia de eventos potencialmente peligrosos como inundaciones, anegamientos y desbordes.
Ciudades y conectividad: transporte aéreo y ferroviario de alta velocidad en España
Authors: Díez Pisonero Roberto
Published: May 2024

Basándose en teorías clásicas de carácter gravitacional y utilizando técnicas estadísticas apoyadas en análisis de regresión, de correlación y de conglomerados, este trabajo analiza el significado diferencial de los centros españoles en las redes de transporte aéreo y de la alta velocidad ferroviaria (AVF).
Los resultados muestran la fuerte distorsión entre las redes y jerarquías aérea y ferroviaria españolas frente a la jerarquía urbana. Se evidencia, así, que las redes de transporte no responden exclusivamente a una demanda demográfica (relación que existe en cada aeropuerto o estación de AVF entre el número de pasajeros que lo utilizan y el volumen demográfico que podría ser usuario potencial de estas infraestructuras), sino que intervienen otros factores que explican esta disparidad.
Esta distorsión entre las redes y jerarquías permitirá ahondar en una profunda discusión que analizará las particularidades en la configuración de las redes españolas de transporte aéreo y de AVF.
How are teachers being attacked online? On cyberbullying and cyberaggression that targets school educators from the student’s perspective
Authors: Tomczyk Łukasz , Guillén-Gámez Francisco D. , Mascia Maria Lidia , Llorent Vicente J.
Published: May 2024

The twin phenomena of cyberbullying and cyberaggression are among the most common e-threats. Today, much is known about the aggression and violence mediated by new media and targeted at students. However, there is still an empirical gap in the consideration of the mechanisms and forms of cyberaggression and cyberbullying targeting teachers. The aim of this study is to present 10 types of cyber-attacks that teachers have been subjected to in Poland in the last few years. The types of attacks presented include vilification in the information space (forums and social networking sites), direct attack using social networks, recording teachers without their consent, online blackmail, creation and dissemination of memes, photomontage, latent cyberbullying, destructive actions in the COVID-19 period, the creation of fake profiles, and the use of a digital tool in an offline environment. The subject of the study was the statements of post-secondary school graduates who had encountered such phenomena. The article highlights the need to increase digital safety for teachers.
El cirujano general en las urgencias hepatobiliares en Colombia desde la visión de los expertos: un estudio cualitativo
Authors: Peña-González Laura , Domínguez-Torres Luis Carlos , Vega-Peña Neil Valentín , Marenco-Aguilar Catalina
Published: May 2024

Introducción. El manejo perioperatorio de las urgencias hepatobiliares por parte del cirujano general es una competencia esperada y se considera un reto por su relativa frecuencia, impacto en la salud del individuo y la economía, así como las implicaciones en el ejercicio clínico confiable y de alta calidad. Se desconocen los aspectos formales de la educación en cirugía hepatobiliar para el cirujano general en Colombia. El objetivo del presente estudio fue explorar la perspectiva de los cirujanos hepatobiliares sobre esta problemática.
Métodos. Se realizó un estudio cualitativo, mediante entrevistas semiestructuradas con 14 especialistas en cirugía hepatobiliar colombianos, en donde se exploraron los desafíos del entrenamiento, el tiempo y las características de una rotación, la evaluación de la confiabilidad, el número de procedimientos y el rol de la simulación. Se hizo un análisis temático de la información.
Resultados. Los expertos mencionaron la importancia de la rotación obligatoria por cirugía hepatobiliar para los cirujanos en formación. El tiempo ideal es de tres meses, en el último año de residencia, en centros especializados, con exposición activa y bajo supervisión.
Conclusiones. Por las características epidemiológicas del país y la frecuencia de enfermedades hepatobiliares que requieren tratamiento quirúrgico, es necesario que el cirujano general cuente con una formación sólida en este campo durante la residencia. El presente estudio informa sobre las características ideales del entrenamiento en este campo desde la visión de los expertos colombianos.
Standardization of Marking of the Surgical Borders According to the Fibonacci (Golden) Ratio in Female Genital Aesthetic Surgery: Presentation of a Novel Marking Gadget
Authors: Okuyan Erhan , Gunakan Emre , Peker Nurullah
Published: May 2024

The anatomy of the female external genitalia may differ due to developmental or acquired events. However, several anatomical landmarks such as the anterior and posterior commissures, glans clitoridis, and perineal body do not differ across most patients and can be used to evaluate post-surgical tissue symmetry and proportion. Patient preference seems to be subjective; interestingly, however, the desired post-surgical appearance is very similar in itself, almost to the standard in most patients. In addition, surgeons may change the entire process according to their individual aesthetic perceptions and experience. Thus, the outcomes of genital aesthetic surgery may be affected by multiple factors, with patient preference and surgical evaluation and approach appearing to be the most person-dependent. From this perspective, we defined a sticker model for marking the external female genitalia in genital aesthetic surgery. Inspired by the golden ratio, we incorporated the Fibonacci spiral in the stickers.
Mycotoxicoses in Veterinary Medicine: Fusarium Toxins, Grass Staggers, and Neothyphodium Toxins
Authors: Malekinejad Hassan , Alenabi Aylar , Fink-Gremmels Johanna
Published: May 2024

Fungi are a large group of eukaryotic microorganisms that can readily adapt to diverse environments and occur in almost all climatic zones and continents. Although some fungi are inevitable in the environment for the decay and recycling of organic material, many species are known to produce secondary metabolites, and these mycotoxins, when ingested with food or feed materials, can adversely affect animal and human health. Among the toxigenic fungi, Fusarium species are recognized as so-called field fungi, invading crops and producing mycotoxins predominantly before harvest. Fusarium produces a wide array of mycotoxins, causing different plant diseases. Fusariosis causes significant economic losses in a wide range of crops. Fusarium secondary metabolites, particularly trichothecenes, are potent toxins in mammalian species and cause diverse adverse effects in humans and animals. Other prominent Fusarium toxins with entirely different chemical structures are zearalenone and its derivatives and fumonisins. With an entirely different life cycle, toxins of endophytes belonging to the genus Epichloë and Neothyphodium coenophialum and Neothyphodium lolii comprise an animal health risk, particularly for grazing animals. This review aimed to summarize the adverse effects of selected Fusarium and Epichloë toxins, with a special emphasis on their occurrence in roughages and their mechanisms of action, and describe their effect on animal health and welfare and the potentially related public health risks.
ARHGAP10, Transcriptionally Regulated by Sodium Butyrate, Promotes Ferroptosis of Ovarian Cancer Cells
Authors: Ke Huihui , Shao Juan , Hu Jiachang , Song Xumin , Han Hongyu , Zhu Zhanpeng , Zhou Xinying , Chen Li , Shan Ying
Published: May 2024

Background: Ovarian cancer is a highly lethal gynecologic malignancy. ARHGAP10, a member of Rho GTPase-activating proteins, is a potential tumor suppressor in ovarian cancer. However, its role and the involved mechanism need further examination. Here, we investigated whether ARHGAP10 is also associated with ferroptosis. Methods: Lentivirus infection was used for gene overexpression or silencing. Real-time polymerase chain reaction (RT-PCR) and Western blot were used to assess mRNA and protein levels, respectively. Cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. Lipid reactive oxygen species level was measured by flow cytometry. A tumorigenicity assay was performed to evaluate tumor growth in vivo, and sections of mouse tumor tissues were examined by immunofluorescence microscopy. Chromatin Immunoprecipitation (ChIP) assay was used to assess the binding of H3K9ac to the promoter region of ARHGAP10. Results: ARHGAP10 overexpression promoted ferroptosis in ovarian cancer cells, resulting in decreased cell viability, and increased lipid reactive oxygen species (ROS) level. Further, it decreased and increased GPX4 and PTGS2 expression, respectively, and also induced suppression of tumor growth in mice. Fer-1, a potent inhibitor of ferroptosis, suppressed the above effects of ARHGAP10. Contrarily, ARHGAP10 silencing alleviated ferroptosis in ovarian cancer cells, which was reversed by RSL3, a ferroptosis-inducing agent. Lastly, sodium butyrate (SB) was found to transcriptionally regulate ARHGAP10, thereby also contributing to the ferroptosis of ovarian cancer cells. Conclusions: Our results suggest that SB/ARHGAP10/GPX4 is a new signaling axis involved in inducing ferroptosis in ovarian cancer cells and suppressing tumor growth, which has potential clinical significance.
Redox TRPs in Ischemia-Reperfusion Injury and Their Pharmacological Value
Authors: Ren Ming , Sun Lu-Lu , Tu Yu-Chi , Feng Li , Yao Li-Jun
Published: May 2024

Ischemia-reperfusion injury (IRI) is a complex phenomenon. Although researchers have long been aware of IRI, its complex signaling events and potential therapeutic targets are still an active research area. The role of reactive oxygen species in IRI has garnered great interest among scientists. Recent studies have found that reactive oxygen species produced by IRI can activate redox-sensitive transient receptor potential channels (redox TRPs). The discovery of redox TRPs provides a new perspective for understanding the mechanism of IRI.
Research Progress of Warburg Effect in Hepatocellular Carcinoma
Authors: Yang Yanguang , Gao Yuting , Xiong Yajun , Gong Yi , Lu Junlan , Zhang Yuman , Wang Dan , Liu Zhihan , Shi Xinli
Published: May 2024

The Warburg effect, also called aerobic glycolysis, refers to tumor cells that metabolize glucose through glycolysis even in the presence of oxygen. This rapid breakdown of glucose fuels the fast development, growth, and migration of tumor cells. Lactate, the final product of aerobic glycolysis, contributes to an acidic environment within the tumor, promoting the formation of an immunosuppressive microenvironment and accelerating tumor progression by impeding anti-tumor immunity. Numerous studies have confirmed the critical role of aerobic glycolysis in the occurrence and development of hepatocellular carcinoma by influencing tumor cells proliferation, invasion, metastasis, apoptosis, immune escape, angiogenesis, and more. Clinical trials have shown that inhibitors of rate-limiting enzymes in the glycolysis pathway can enhance the effectiveness of sorafenib, a targeted drug for hepatocellular carcinoma, by reducing drug resistance. Additionally, active components of traditional Chinese medicine and specific compound prescriptions are gaining attention for their potential to target and regulate aerobic glycolysis in hepatocellular carcinoma. Therefore, inhibiting the aerobic glycolysis pathway holds promise as a therapeutic strategy for treating liver tumors. This manuscript aims to review the role, research directions, and clinical studies of aerobic glycolysis in hepatocellular carcinoma.