Evaluating the Appropriate Use Criteria for Coronary Revascularization in Stable Ischemic Heart Disease Using Randomized Data From the ISCHEMIA Trial
Authors: Slater James , Maron David J. , Jones Philip G. , Bangalore Sripal , Reynolds Harmony R. , Fu Zhuxuan , Stone Gregg W. , Kirby Ruth , Hochman Judith S. , Spertus John A. , Mavromatis Kreton , Linefsky Jason , Miller Todd , Banerjee Subhash , Newman Jonathan D. , Donnino Robert M. , Saric Muhamed , Abdul-Nour Khaled , Stone Peter H. , Jang James J. , Yee Gennie , Weitz Steven , Arnold Suzanne , O’Keefe James Henry , Shapiro Michael D. , Fein Steven A. , Torosoff Mikhail T. , Lyubarova Radmila , Mookherjee Sulagna , Drzymalski Krzysztof , McFalls Edward O. , Garcia Santiago A. , Bertog Stefan C. , Siddiqui Rizwan A. , Ishani Areef , Hansen Ronnell A. , Khouri Michel Georges , Goldberg Jonathan L. , Goldweit Richard , Cohen Ronny A. , Mirrer Brooks , Navarro Victor , Winchester David E. , Kronenberg Marvin , McFarren Christopher , Heitner John F. , Dauber Ira M. , Cannan Charles , Sudarshan Sriram , Mehta Puja K. , McDaniel Michael , Lerakis Stamatios , Quyyumi Arshed , Wenger Nanette K. , Hedgepeth Chester M. , Hurlburt Heather , Rosen Alan , Sahul Zakir , Leung Steve , Reda Hassan , Ziada Khaled , Setty Sampoornima , Barua Rajat S. , Hage Fadi , Davies James E. , Leesar Massoud , Heo Jaekyeong , Iskandrian Amy , Al Solaiman Firas , Singh Satinder , Dajani Khaled , El-Hajjar Mohammad , Der Mesropian Paul , Sacco Joseph , McCandless Brian , Orgera Marisa , Sidhu Mandeep S. , Arif Imran , Kerr Hanan , Trejo (Gutierrez) Jorge F. , Fletcher Gerald , Lane Gary E. , Neeson Lynn M. , Parikh Pragnesh P. , Pollak Peter M. , Shapiro Brian P. , Landolfo Kevin , Gemignani Anthony , O’Rourke Daniel , Meadows Judith L. , Call Jason T. , Hannan Joseph , Bojar Robert , Kumar Deepti , Mukai John , Martin Edward T. , Vorobiof Gabriel , Moorman Alec , Kinlay Scott , Hamburger Robert J. , Rocco Thomas P. , Bhatt Deepak L. , Croce Kevin , Quin Jacquelyn A. , Anumpa Jati , Zenati Marco , Faxon David P. , Rayos Glenn , Seedhom Ashraf , Sullenberger Lance , Kumkumian Gregory , Sedlis Steven P. , Donnino Robert M. , Lorin Jeffrey , Tamis-Holland Jacqueline E. , Kornberg Robert , Leber Robert , Saba Souheil , Lee Michael W. , Small Delano R. , Nona Wassim , Alexander Patrick B. , Rehman Iram , Badami Umesh , Marzo Kevin , Robbins Inga H. , Levite Howard A. , Shetty Sanjay , Patel Mayuri , Hamroff Glenn S. , Little Raymond W. , Zimbelman Brandi D. , Lui Charles Y. , Smith Brigham R. , Vezina Daniel P. , Khor Lillian L. , Abraham Josephine D. , Bull David A. , McKellar Stephen H. , Booth David , Kotter John , Abdel-Latif Ahmed , Hu Bob , Labovitz Arthur J. , Berlowitz Michael , Rogal Philip , Matar Fadi , Caldeira Christiano , Rodriguez Fatima , Schnittger Ingela , Fearon William F. , Deedwania Prakash , Reddy Kiran , Sweeny Joseph , Spizzieri Christopher , Hochberg Claudia P. , Salerno William D. , Wyman Ray , Zarka Amer , Shah Anil V. , Haldis Thomas , Kohn Jeffrey A. , Girotra Saket , Almousalli Omar , Krishnam Mayil S. , Milliken Jeffrey C. , Patel Pranav M. , Seto Arnold H. , Harley Kevin T. , Gibson Michael A. , Allen Byron J. , Coram Rita , Thomas Sabu , Schwartz Ronald G. , Chen Wei , El Shahawy Mahfouz , Stafford James , Abernethy William B. , Zurick Andrew , Meyer Thomas M. , Morford Ronald G. , Rutkin Bruce , Bokhari Sabahat , Sokol Seth I. , Meisner Jay , Hamzeh Ihab , Misra Arunima , Wall Matthew , De Rosen Veronica Lenges , Alam Mahboob , Turner Michael C. , Mulhearn Thomas J. , Good Arnold P. , Shammas Nicolas W. , Chilton Robert , Nguyen Patricia K. , Jezior Matthew , Gordon Paul C. , Crain Thomas , Stenberg Robert , Pedalino Ronald P. , Wiesel Joseph , Juang George J. , Al-Amoodi Mohammed , Wohns David , Lader Ellis W. , Mumma Michael , Dharmarajan Lekshmi , McGarvey Joseph F.X. , Downes Thomas R. , Luckasen Gary J. , Cheong Benjamin , Potluri Srinivasa , Mastouri Ronald A. , Breall Jeffery A. , Revtyak George E. , Bazeley Jonathan W. , Li Dayuan , Giedd Kenneth , Old Wayne , Burt Francis , Sokhon Kozhaya , Gopal Deepika , Valeti Uma S. , Kobashigawa Jon , Govindan Sajeev Chakanalil , Nair Rajesh Gopalan , Manjunath Cholenahally Nanjappa , Moorthy Nagaraja , Manjunath Satvic Cholenahally , Narayanappa Suryaprakash , Pandit Neeraj , Nath Ranjit Kumar , Dwivedi S.K. , Narain V.S. , Chandra Sharad , Wander Gurpreet S. , Tandon Rohit , Ralhan Sarju , Aslam Naved , Goyal Abhishek , Karthikeyan G. , Ramakrishnan S. , Seth Sandeep , Yadav Rakesh , Singh Sandeep , Roy Ambuj , Parakh Neeraj , Verma Sunil Kumar , Narang Rajiv , Mishra Sundeep , Naik Nitish , Sharma Gautam , Choudhary Shiv Kumar , Patel Chetan , Gulati Gurpreet , Sharma Sanjeev , Bahl V.K. , Mathew Anoop , Punnoose Eapen , Gadage Siddharth , Umesh Pillay Tapan , Satheesh Santhosh , Mathur Atul , Christopher Johann , Menon Rajeev , Kumar Nirmal , Oomman Abraham , Mao Robert , Solomon Hilda , Parveen Khan Sajeeda , Grant Purvez , Kachru Ranjan , Ajit Kumar V.K. , Ganapathi Sanjay , Jayakumar K. , Sivadasanpillai Harikrishnan , Sasidharan Bijulal , Kapilamoorthy T.R. , Polamuri Praneeth , Kaul Upendra , Fox Keith A.A. , Carruthers Kathryn , Elghamaz Ahmed , Gurunathan Sothinathan , Karogiannis Nikolaos , Shah Benoy N. , Trimlett Richard H.J. , Rubens Michael B. , Nicol Edward D. , Mittal Tarun K. , Hampson Reinette , Gamma Reto Andreas , de Belder Mark A. , Thambyrajah Jeet , Nageh Thuraia , Davies John R. , Lindsay Steven J. , Kurian John , Jamil Haqeel , Raheem Osama , Hoye Angela , Donnelly Patrick , Valecka Bernardas , Chauhan Anoop , Barr Craig , Alfakih Khaled , Byrne Jonathan , Webb Ian , Henriksen Peter , OKane Peter , de Silva Ramesh , Conway Dwayne S.G. , Sirker Alexander A. , Hoole Stephen P. , Witherow Fraser N. , Johnston Nicola , Harbinson Mark , Walsh Simon , Douglas Hanna , Luckie Matthew , Sobolewska Jolanta , Jeetley Paramjit , Patel Niket , Kotecha Tushar , Travill Christopher , Karimullah Iqbal , Al-Bustami Mahmud , Braganza Denise , Henderson Robert , Pointon Kate , Naik Surendra , Mathew Thomas , Berry Colin , Collison Damien , Roditi Giles , Moriarty Andrew J. , Glover Jason D. , Pradhan Jiwan , Ghada Mikhail , Francis Darrel P. , Dzavik Vladimir , Diaz Ariel , Rheault Philippe , Barrero Miguel , Gagné Carl-Éric , Pépin-Dubois Yanek , Costa Ricardo , Sia Ying Tung , Lemay Catherine , Gisbert Alejandro , Gervais Pierre , Rheault Alain , Carl Phaneuf Denis , Gosselin Gilbert , Garg Pallav , Hessian Renee C. , Beanlands Rob S. , Davies Richard F. , Cheema Asim N. , Bagai Akshay , Wald Ron , Goodman Shaun , Graham John Joseph , Peterson Mark , Chow Chi-Ming , Abramson Beth , Cheema Asim Nazir , Tariq Vakani Mohammad , Cha James , Howarth Andrew G. , Wong Graham , Uxa Amar , Galiwango Paul , Kassam Saleem , Mukherjee Ashok , Joseph Ricci A. , Lam Andy , Mehta Shamir , Udell Jacob , Généreux Philippe , Hameed Adnan , Daba Ledjalem , Hueb Whady , Cury Rezende Paulo , Hueb Alexandre Ciappina , Poggio Smanio Paola Emanuela , de Quadros Alexandre Schaan , Karam Kalil Renato Abdala , da Costa Vieira José Luiz , Grossmann Gabriel , de Oliveira Pedro Píccaro , Bridi Leonardo , Savaris Simone , Vitola João V. , Cerci Rodrigo J. , Farias Fabio R. , Fernandes Miguel M. , Marin-Neto José Antonio , Schmidt André , de Oliveira Lima Filho Moysés , Mendes Oliveira Ricardo , Abbud Chierice João Reynaldo , Polanczyk Carísi A. , Furtado Mariana V. , Smidt Luis F. , Carlos Carvalho Antonio , Pucci Gustavo , Lyra Flavio , Alves Junior Alvaro Rabelo , Dracoulakis Marianna D.A. , Lima Rodolfo G.S.D. , Figueiredo Estevao , Caramori Paulo Ricardo , Tumelero Rogerio , Dall’Orto Frederico , Mesquita Claudio T. , Colafranseschi Alexandre S. , Oliveira Amarino C. , Carvalho Luiz A. , Palazzo Isabella C. , Sousa Andre S. , da Silva Expedito Eustáquio Ribeiro , de Barros e Silva Pedro Gabriel Melo , de Pádua Silva Baptista Luciana , Rodrigues Marcelo Jamus , de Resende Marcos Valério Coimbra , Saraiva Jose Francisco , Costantini Costantino , Ruzyllo Witold , Demkow Marcin , Pracon Radoslaw , Kepka Cezary , Teresinska Anna , Kryczka Karolina , Henzel Jan , Solecki Mateusz , Kaczmarska Edyta , Mazurek Tomasz , Drozdz Jaroslaw , Czarniak Bartosz , Frach (formerly Stasiak) Malgorzata , Szymczyk Konrad , Niedzwiecka Iwona , Sobczak Sebastian , Ciurus Tomasz , Jakubowski Piotr , Misztal-Teodorczyk Magdalena , Teodorczyk Dawid , Fratczak Aleksandra , Szkopiak Marcin , Lebioda Patrycja , Wlodarczyk Michal , Plachcinska Anna , Kusmierek Jacek , Miller Magdalena , Marciniak Halina , Wojtczak-Soska Karolina , Łuczak Katarzyna , Tarchalski Tomasz , Cichocka-Radwan Anna , Anna Szulczyk Grazyna , Witkowski Adam , Kukuła Krzysztof , Celińska-Spodar Małgorzta , Zalewska Joanna , Gajos Grzegorz , Bury Krzysztof , Pruszczyk Piotr , Roik Marek , Łoboz-Grudzień Krystyna , Sokalski Leszek , Brzezińska Barbara , Lesiak Maciej , Łanocha Magdalena , Reczuch Krzysztof W. , Kalarus Zbigniew , Swiatkowski Andrzej , Szulik Mariola , Musial Wlodzimierz J. , Bockeria Leo , Petrosyan Karen , Trifonova Tatiana , Chernyavskiy Alexander M. , Kretov Evgeniy I. , Grazhdankin Igor O. , Bershtein Leonid L. , Sayganov Sergey A. , Kuzmina-Krutetskaya Anastasia M. , Zbyshevskaya Elizaveta V. , Katamadze Nana O. , Demchenko Elena A. , Kozlov Pavel S. , Kozulin Vikentiy Y. , Lubinskaya Ekaterina I. , Lopez-Sendon Jose , Castro Almudena , Refoyo Salicio Elena , Guzman Gabriela , Galeote Gabriel , Valbuena Silvia , Peteiro Jesús , Martínez-Ruíz María Dolores , Pérez-Fernández Ruth , Cuenca-Castillo José J. , Flores-Ríos Xacobe , Prada-Delgado Óscar , Barge-Caballero Gonzalo , Gonzalez Juanatey Jose Ramon , Bayarri Miguel Souto , Pubull Nuñez Virginia , Sanchez Raymundo Ocaranza , Alvarez Belen Cid , Gil Carlos Peña , Monzonis Amparo Martinez , Sionis Alessandro , Vila Perales Montserrat , Padró Josep Maria , Peñaranda Antonio Serra , García Picart Joan , Ginel Iglesias Antonino , Marimon Xavier Garcia-Moll , Lladó Guillem Pons , Costa Francesc Carreras , Miro Vicente , Diez Jose L. , Calvillo Pilar , Marin Ortuño F. , Valdés Chávarri M. , Tello Montolliu A. , Pinar Bermudez E. , De La Morena G. , Gracida Blancas Montserrat , Castillo Luena Jose Enrique , Fernandez-Aviles Francisco , Chen Jiyan , Wu Yongjian , Ma Yitong , Yang Yining , Ji Zheng , Yang Xinchun , Lin Wenhua , Zeng Hesong , Fu Xin , Wang Songtao , Cheng Gong , Zhao Yulan , Fang Xuehua , Zeng Qiutang , Su Xi , Li Qingxian , Nie Shao-ping , Yu Qin , Wang Jian’an , Zhang Shuyang , Liu Zhenyu , Maggioni Aldo P. , Perna Gian Piero , Marini Marco , Gabrielli Gabriele , Provasoli Stefano , Verna Edoardo , Monti Lorenzo , Nardi Barbara , Di Chiara Antonio , Mortara Andrea , Galvani Marcello , Ottani Filippo , Sicuro Marco , Calabro Paolo , Formisano Tiziana , Tarantini Giuseppe , Cucchini Umberto , Andres Anto Luigi , Racca Emanuela , Briguori Carlo , Amati Roberto , Vergoni William , Russo Aldo , Fanelli Raffaele , Poh Kian-Keong , Chai Ping , Lau Titus , Loh Joshua P. , Tay Edgar L. , Teoh Kristine , Teo Lynette L. , Ong Ching-Ching , Wong Raymond C. , Loh Poay-Huan , Kofidis Theodoros , Chan Wan Xian , Chan Koo Hui , Foo David , Kong Jason Loh Kwok , Er Ching Min , Jafary Fahim Haider , Chua Terrance , Stumpf Juergen , Matschke Klaus , Simonis Gregor , Kadalie Clemens T. , Sechtem Udo , Christian Schulze P. , Goebel Bjoern , Lenk Karsten , Nickenig Georg , Schuchlenz Herwig , Weikl Stefan , Marthe Lang Irene , Huber Kurt , Jakl-Kotauschek Gabriele , Keltai Matyas , Vertes Andras , Varga Albert , Fontos Geza , Merkely Bela , Kerecsen Gabor , Hinic Sasa , Zdravkovic Marija , Mudrenovic Vladan , Crnokrak Bogdan , Beleslin Branko D. , Boskovic Nikola N. , Petrovic Marija T. , Dobric Milan R. , Markovic Zeljko Z. , Mladenovic Ana S. , Cemerlic-Adjic Nada , Davidović Goran , Vučić Rada , Nikola Dekleva Milica , Stankovic Goran , Apostolovic Svetlana , Escobedo Jorge , Baleón-Espinosa Rubén , Campos-Santaolalla Arturo S. , Durán-Cortés Elihú , Flores-Palacios José M. , García-Rincón Andrés , Jiménez-Santos Moisés , Peñafiel Joaquín V. , Ortega-Ramírez José A. , Valdespino-Estrada Aquiles , Alexánderson Rosas Erick , Murphy Deirdre , Selvanayagam Joseph B. , Joseph Majo X. , Thambar Suku T. , Rankin (past) Jamie , Beltrame John F. , Hillis Graham S. , Thuaire Christophe , Dutoiu Téodora , Juliard Jean-Michel , Slama Michel S. , El Mahmoud Rami , Nicollet Eric , Goube Pascal , Barone-Rochette Gilles , Furber Alain , Bière Loïc , Laucevicius Aleksandras , Kedhi Elvin , Timmer Jorik , Hermanides Rik , Kaplan Eliza , Riezebos Robert K. , Samadi Pouneh , van Dongen Elise , Niehe Sander R. , Suryapranata Harry , van Vugt Stijn , Cacela Duarte , Santana Ana , Fiarresga Antonio , Sousa Lidia , Marques Hugo , Patricio Lino , Bernanrdes Luis , Rio Pedro , Carvalho Ramiro , Ferreira Rui , Silva Tiago , Rodrigues Ines , Modas Pedro , Portugal Guilherme , Fragata Jose , Pinto Fausto J. , Menezes Miguel Nobre , Cantinho Lopes Guilhermina , Almeida Ana Gomes , Silva Pedro Canas , Nobre Angelo , Francisco Ana Rita , Ferreira Nuno , Lopes Ricardo L. , Diaz Rafael , Guzman Luis , César Figal Julio , Méndiz Oscar , Cortés Claudia , René Favaloro Roberto , Alvarez Carlos , Courtis Javier , Zeballos Gabriela , Schiavi Lilia , Rubio Mariano , Alsweiler Caroline , Patrick Devlin Gerard , Fisher Raewyn , Huston Stewart Ralph Alan , Douglas White Harvey , Benatar Jocelyne , Kedev Sasko , Peovska Mitevska Irena , Srbinovska Kostovska Elizabeta , Pejkov Hristo , Held Claes , Eggers Kai , Frostfelt Gunnar , Johnston Nina , Olsowka Maciej , Åkerblom Axel , Soveri Inga , Aspberg Johannes , Beyar Rafael , Nikolsky Eugenia , Sharir Tali , Elian Dan , Kerner Arthur , Massalha Samia , Fukuda Keiichi , Kohsaka Shun , Yasuda Satoshi , Nishimura Shigeyuki , Van de Werf Frans , Claes Kathleen , Hung Chung-Lieh , Yun Chun-Ho , Hou Charles Jia-Yin , Kuo Jen-Yuan , Yeh Hung-I , Hung Ta-Chuan , Li Jiun-Yi , Chien Chen-Yen , Tsai Cheng-Ting , Liu Chun-Chieh , Yu Fa-Chang , Lin Yueh-Hung , Lan Wei-Ren , Yen Chih-Hsuan , Tsai Jui-Peng , Sung Kuo-Tzu , Ntsekhe Mpiko , Pandie Shaheen , Viljoen Charle A. , De Andrade Marianne , Moccetti Tiziano , Grazia Rossi M. , Abdelhamid Magdy , Adel Ahmed , Kamal Ahmed , Mahrous Hossam , El Kaffas Sameh , El Fishawy Hussien , Pop Calin , Claudia Matei , Popescu Bogdan A. , Ginghina Carmen , Deleanu Dan , Iliescu Vlad A. , Al-Mallah Mouaz H. , Aljzeeri Ahmed , Najm Hani , Alghamdi Ali , Mogrovejo Ramos Walter Enrique , Kuanprasert Srun , Prommintikul Arintaya , Nawarawong Weerachai , Woragidpoonpol Surin , Tepsuwan Thitipong , Taksaudom Noppon , Rimsukcharoenchai Chataroon , Euathrongchit Juntima , Wannasopha Yutthaphan , Yamwong Sukit , Sritara Piyamitr , Aramcharoen Suthara , Meemuk Krissada , Khairuddin Ahmad , Abd Hadi Hafidz , Azmi Yahaya Shaiful , Doan John , Lee Raven , Patel Risha , Yang Cho So , Milbrandt Susan , Shelstad Dawn , Kamath Preeti , Tejani Ishita , Quiles Kirsten J. , Schley Allison , Golden Heather , Osseni Hermine , Wiyarand Charlene , Douglass Peter , Pomeroy Hayley , Craft Alexandra , Harvey Bethany , Anaya Olivia , Goold Phoebe , Giovannone Steven , Pritchard Lori , Gans Rosann , Kennedy Paul , Ganesan Shobana , Schlichting David , Naher Aynun , Stewart Wendy L. , Salmi Kristin M. , Johnson Debra K. , Herrmann Rebekah R. , Arges Kristine , LeFevre Melissa , Tomfohr Jennifer , Ann Byrne Kimberly , Zappernick Taissa , Canada Sallie , Kakade Meghana , Mieses Patricia , Cobos Stanley E. , Dwyer Raven R. , Espinosa Dalisa , Quiles Kirsten J. , Rantinella Magdalena , Rodriguez Jessica , Mancilla Olivia , Stinson Susan , Weyand Terry , Crook Sherron C. , Ho Jean , Khan Saadat , Mohamed Mahmoud , Soltau Mary R. , Rose Delsa K. , Wimmer Rebecca J. , Siegel Kathy E. , Derbyshire Susan , Dixon Michelle , Leonard Gerald , Heard Ciarra , Gabriel Viviana , Desire Sukie , Rashid Fauzia , Asier Senait , Patel Keyur , Gillis Jennifer , Manocchia Megan , Moore Susan , Congdon Elizabeth , Brandt Gail , Marchelletta Nora , Wippler Kristina , Halverson Kimberly E. , Roraff Christine , Thorsen Jonean , Ojajuni Amarachi , Olurinde Oni , Surineni Kamalakar , Valaiyapathi Badhma , Kartje Carol M. , Rawlins Michele , Thomson Jennifer , Colleen Rogge Mary , Bunke Julie , Unterbrink Kendra , Fannon Jacqueline , Burman Cynthia , Dubin Marcia F. , Beaudry Sarah , Tirado Stephanie A. , Halliday Janet , Julian Pamela , Lane Stephanie M. , Stanford Jennifer L. , Arsenault Patricia , Sigel Pamela , Brooks Miriam , Douangvila Ladda , Gevorgyan Rubine , Ranjbaran Fatima , Smith Bryn , Ohmart Carly , Ly Samantha , Quinn Margot C. , Temiyasathit Sara , Do Jacquelyn , Tobin Desiree , Langdon Jennifer , Werner Bayer Marcia , O’Malley Amanda , Orvis Erin , Murphy Mandy , Greenberg Ann , Iraola Margaret , Maranan Leandro C. , Malinay Ammy , Edillo Candice P. , Ostrander Ann , Wasmiller Stephanie , Drewes Wendy , Patel Dipti , White Jackie M. , Hallam Alison , Spooner Benjamin J. , Hollenweger Linda M. , Little Holly , Little Tiffany , Eskelson Nona A. , Taul Yvonne , Rodgers Caroline , Isaacs Jennifer , Bulkley Viktoria , Kaneshiro Renee , Kirby Bonnie J. , Tran Nhi N. , Jahrsdorfer Catherine , Yunis Reem , Patro Jhina , Vega Antonia , Bloise-Adames Hugo , Jimenez Santa , Saint Vrestil Nicole , Bhandari Reyna , Schade Danielle , Yost Roxanne , Beardsley Paula , Fine Denise , Tancredi Jana , Arakelian Patricia , Mathus Susan , O’Neill Deborah , Burkhardt Joy , Hosino Suellen , Lubyanaya Oksana A. , Salas Jose D. , Aguirre Maria , Dhawan Manu , Parra Diana , Tran Tri , Fowler-Lehman Katie , Spitzer Natalie , Riedberger Casey , Weick Catherine , Quiles Kirsten J. , Drum Carrie , Miller-Cox Kimberly , Ollinger Amy , Capasso-Gulve Elizabeth , Melanie Loehr Alaine , Mosley Marlowe , Heydari Shirin , Lundeen Andrea M. , Karanjah Edgar , Marfori Wanda C. , Hernandez-Rangel Eduardo , Singh Pam , Webb Anne Marie , Fridell Ellie , Wilson Heidi , Kim Angela , Wilmot Patrick , Stevens Ramona , Black Loriane , Hull Amber B. , Lim Olivia J. , Tucker Helen C. , Putnam Natasha C. , Hall Linda L. , Cauthren Tia , Tucker Trish , Horton Hollie , Orga Jan , White Joyce R. , Baumann Cynthia , Seeratan Vidya , Jimenez Magnolia , Schultz Cidney , Russo Jeanne , Huda Zohra , Boan Araceli , Hinton Christine R. , Archer Beth A. , Dionne Julia S. , Allardyce Cheryl A. , Sikora Lindsey N. , Czerniak Jennifer H. , Mull Jennifer A. , Ferguson Elizabeth , Laube Frances , Shammas Gail A. , Christensen Lori , Park Holly , Hecht Joan , Vo Davis , Hirsch James , Bindeman Jody , Salkind Sara , Desimone Lori-Ann , Felix-Stern Lina , Gomes Jassira , Gordon Catherine , Mann Aimee , McCreary Theresa , Quiles Kirsten J. , Gopaul Candace , Hultberg Karen , Huk Tauqir , Hussain Afshan , Zambrano Yesenia , Rodriguez Sarah Medina , Milner Trudie , Mulder Abbey , Van Oosterhout Stacie , Meyer Martha , Clapp Nancy L. , Barrentine Heather , Jose Jenne M. , Manchery Jenne , McKinney Vera , Schwarz Linda , Kaczkowski Scott M. , Jaskowiak Adam J. , Klitch Joel , Dees Debra , Vasquez Precilia , Hannemann Elise L. , Mae Foltz Judy , DeRosa Emily , Jorgenson Beth , Riestenberg-Smith Joyce , Bariciano Rebecca , Waldron Jessica , Mayon Michelle , Ann Peichel Gretchen , Starks Brandy , Garcia Lucilla , Thottam Maria , Anand Anjali , Raj Janitha , Ravindran Reshma , Rajalekshmi VS , Nataraj Nandita , Bajaj Sheromani , Yadav Vandana , Mishra Girish , Tewari Roma , Mishra Meenakshi , Patel Shivali , Singh Suman , Kaur Baljeet , Gupta Sonika , Suvarna Chandini , Kurian Binoy Mannekkattukudy , Rupesh Karwa Sheetal , Kolhe Suvarna , Vindhya R.J. , Jain Peeyush , Seth Ashok , Meharwal Zile Singh , Verma Atul , Bhatia Mona , Sachdeva Ankush , Indira Devi Thounaojam , Jungla Nungshi , Manjula Rani K. , Sowjanya Reddy M. , Preethi K. , Sidh Rinu R. , Priya Vamshi , Preethi Kotiboinna , Hande Shweta , Dubey Abhishek , Rawat, Vineeth Kavita , Vineeth CP , Chacko Manas , Babu Suresh , Reddy Sowjanya , Rani Manjula , Arambam Priyadarshani , Singh Bebek , Young Grace M. , Kinsey Christopher , Kavalakkat Raisa , Evans Jo , Hassan Ikraam , Williams Sarah , Holland Kim , Swan Karen , Atkinson Bev , Kunhunny Swapna , Atkinson Craig , Krannila Carita , Vinod Manitha , Chaytor Lisa , Cox Leanne , Morrow Julie , Rowe Kay , Kelly Stephanie , Regan Susan , Turnbull Dawn , Fleming Catherine , Ghosh Arijit , Gratrix Karen , Preston Stephen , Cartwright Anne , Knightonc Abigail , Martin Katherine , Flint Laura , Harrison James , Lakeman Nicki , Ljubez Anja , Wright Judith , Exley Donna , Andiapen Mervyn , Richards Amy J. , Wong Lisa , Munro Melanie J. , McEvoy Michelle , Brown Caroline , Charles Thabitha , Kolakaluri Laurel , Phillips Hannah , Morby Louise , Hallett Karen , Corbett Carolyn , Winstanley Lynne , Smit Angelique , Gent Susan , Hussain Nafisa , Haines Fiona , Taaffe Joanne , Burton Jane , Colton Maria , King Rachel , Brown Ammani , Docherty Andrew , McCloy Lisa , Robb Kate , Paterson Craig , Crawford Wenda , Kelly Joanne , McGregor Lorraine , Mackin Anne , Knight Janet P. , Bose Tuhina , Proietti Anna , Brousseau Myriam , Corfias Magalie , Blaise Patricia , Harvey Luc , Alarie Patricia , Arcand Linda , Roy Isabelle , Montpetit Estelle , Drouin Katia , Bergeron Christine , Shelley Christine , Masson Christine , Carr Sandy , Bone Catherine , Moga Ermina , Kourzenkova Janetta , Walter Olga , Hogg Norma , Welsh Suzanne , Hussain Mohammed , Bello Olugbenga , Syed Ishba , Kushniriuk Khrystyna , Otis Judy , Otis Rebecca , Seib Michelle M. , Rivest Sandra M. , Sandonato Rosa , Chow Jackie , Starovoytov Andrew , Uchida Naomi , Meadows Ngaire , Asif Nadia , Tavares Suzana , Bozek Bev , Shier Maria , Larmand Lori-Ann , Janmohamed Amir , Hart Brenda , Marucci Jane , Tai Sharon , Brons Sonya , Beck Chris , Wong Glenda , Etherington Krystal , Arumairajah Thippeekaa , Aprile Maria , Karlsson Sara , Webber Susan , Mercure Chantale , Aedy Nancy , Farquharson Fran , Siddiqui Anam , Takiuti Myrthes Emy , Caetano Leonardo Pizzol , Deiro Aline Peixoto , Muller Alice Manica , de Moraes Maria Antonieta Pereira , Ascoli Bruna Maria , Poletti Sílvia Zottis , Zier Sandra S. , Veiga Vilmar , da Cunha Diego Franca , Rucatti Guilherme G. , Igansi Fernanda , Haeffner Mauren P. , Almeida Viviane , de Souza Gabriela Sanchez , Almeida Mayana , dos Santos Viviane , Oliveira Natalia S. , Azevedo Bruna Edilena Paulino , Santos Marco Bizzaro , Germann Amanda , Gomes Vitor , Homem Rosa , Magedanz Ellen , Laimer Rosane , Tognon Alexandre , Santos Roberta P. , Okada Mariana Yumi , Batista Ana Paula , Rabaça Aline Nogueira , Trama Larissa Miranda , Silva Talita , de Souza Ormundo Camila Thais , Vicente Carla , Pinheiro Caroline , Komar Daniele , Walesiak Olga , Malinowska Katarzyna , Maksym Jakub , Wojtera Karolina , Fojt Anna , Szczerba Ewa , Swiderek Marta , Wojtala Ewelina , Karwowski Jaroslaw , Łabyk Andrzej , Szramowska Agnieszka , Zdończyk Olga , Jaroch Joanna , Kolodziej Adam , Marcinkiewicz-Siemion Marta , Bockeria Olga , Kudzoeva Zalina , Aripova Nodira , Naryshkin Ivan A. , Kuleshova Alena , Malaev Dastan , Subbotina Irina , Gumerova Victoria , Nikolaeva Olga B. , Fernández-Figares Virginia , Blanco-Calvo Moisés , Alonso-Álvarez Encarnación , García-González Paula , Seijas Amigo Jose , Fernández Martínez, Ana , Igual Begoña , Quintana Giner M. , Romero Aniorte A.I. , Rivera Caravaca J.M. , Cañavate Olga , Guerrero Sonia , Riera Silvia , Lasala Maria , Lorenzo Maria , Sobrino Olga , Vazquez Alexandra , Dong Haojian , He Peiyu , Xia Chunli , Yang Junqing , Zhong Qi , Tian Yanmeng , Li Dongze , Li Xiaomei , Ma Xiang , Yu Zixiang , Zhao Qian , Li Chunguang , Zhang Lei , Zhao Yu , Zhu Bolin , Chen Mulei , Chi Hongjie , Wang Yang , Zhang Jing , Jing Rui , Liu Jingjing , Zhou Qiang , Xu Chang , Li Zhuxi , Li Junhua , Xiong Luyang , Gao Dan , Jiang Dengke , Leng Ran , Wang Xutong , Yuan Qianqian , Zhang Lili , Bai Ziliang , Li Jianhua , Qi Jie , Wang Fei , Wang Haitao , Yang Bin , Yue Zhou , Zhang Zhulin , Dong Yumei , Mao Jiajia , Zhang Bin , Li Xiuhong , Yao Xiaowei , Zhong Nier , Zhou Ning , Huang Yaping , Zhou Panpan , Su Wei , Kunwu Yu , Peng Yudong , Su Xin , Wang Chen , Zhao Yunhai , Geng Yaming , Wang Yanfu , Fan Jing-yao , Feng Si-ting , Wang Xiao , Yan Yan , Zhang Hui-min , Chi Lingping , Liu Fang , Chen Han , Jiang Jun , Li Huajun , Han Yechen , Xu Lihong , Chen Gang , Hu Rongrong , Pietrucci Francesca , Di Donato Anna , Pezzetta Francesca , Casali Valentina , Attanasio Chiara , Leone Gianpiero , Pisano Francesco , Bare Cristina , Fimiani Fabio , Barioli Alberto , Ramani Federica , Rolfo Fabrizio , Goletto Cecilia , De Micco Francesca , Di Marco Stefano , Tricoli Martina , Villella Massimo , Tan Sik-Yin V. , Sia Winnie C. , Leong Audrey W. , Yan Li Hai , Ismail Nasrul , Kyaw Min Tun , Yip Deborah , Grahl Dorit , Guenther Franziska , Bonin Kerstin , Wenzelburger Ina , Gruensfelder Susanne , Sinning Jan-Malte , Weber Marcel , Werner Nikos , Steinmaurer Gudrun , Winter Max-Paul , Andric Tijana , Tscharre Maximilian , Wegmayrc Claudia , Jäger Bernhard , Egger Florian , Sebo Judit , Davidovits Zoltan , Matics Laszlone , Ágoston Gergely , Dekany Gabor , Bartykowszki Andrea , Jakal Agnes , Djokic Jelena , Djordjevic-Dikic Ana D. , Giga Vojislav L. , Stepanovic Jelena J. , Velicki Lazar , Pupic Ljiljana , Simović Stefan M. , Stevo Martinovic Miroslav , Stevanovic Gordana , Dobric Milan , Martinovic Sonja Salinger , Stanojevic Dragana , de Jesús-Pérez Ramon , Brassetti María Fernanda Canales , Vences Anaya Diego Adrián , García María Pérez , Carvajal Juarez Isabel Estela , Madero Rovalo Magdalena , Lee Sau , Thomas Prince , Chaplin Melissa D. , Stansborough Jeanette K. , Black Marilyn , Bonner Michelle M. , Ireland Kim F. , Venn-Edmonds Clare , Thobois Corine , Tachot Emilie , Laure Christophe , Vassaliere Christel , Abergel Helene , Fuentes Axelle , Eliahou Ludivine , Dubourg Olivier , Michaud Pierre , Hadjih Sarah , Brito Patricia , Cornet Charles , Rautureau Jeremy , Juceviciene Agne , Kalibataite-Rutkauskiene Irma , Keinaite Laura , Laukyte Monika , Mikolaitiene Gelmina , Smigelskaite Akvile , Tamasauskiene Ilona , Urboniene Agne , Bouwhuis Ilse , Nijmeijer Lia , Schoep Jeannette J.M. , Janzen Elisabeth M. , Ahoud Sandra , Selas Mafalda , Silva Filipa , Freixo Cláudia , Cabrita Inês Zimbarra , Rocha Andreia , Figueiras Francisca Patuleia , Coelho Andreia , Capinha Marta , Caetano Maria Inês , Silva Susana , Tinnirello Veronica , Mungo Matías Nicolás , Garcia Marina , Godoy Valeria , Actis Maria Victoria , Scaro Graciela , Low Liz , Scales Jayne , Abercrombie Kirsty , Howell Leah , Patten Cathrine , Björklund Christina , Andreasson Maria , Essermark Marie , Persson Liselotte , Harel Or , Bentzvi Margalit , Helmer Ludmila , Ueda Ikuko , Fujita Jun , Furukawa Akemi , Hirase Kanae , Nagai Toshiyuki , Otsuka Fumiyuki , Nakano Shintaro , Robesyn Valerie , Yang Yi-Hsuan , Mtana Noloyiso , Anesini Adriana , Maspoli Simona , Mombelli Manuela , Talaat Ahmed , Rosca Monica , Beladan Carmen C. , Zahrani Sarah , Davila Marco Antonio Monsalve , Khwakhong Supatchara , Chaiyasri Anong , Mekara Warangkana , Kulthawong Supap , Amaritakomol Anong , Panpunuan Pachara , Mokhtar Noor Syamira , Asiah Basri Nor , Yusnida Irni , Hashim Humayrah , Berger Jeffrey , Williams David , Harrington Robert , Jiang Lixin , Lopes Renato D. , Noel Bairey Merz C. , Weintraub William , Rodríguez Erick Donato Morales , Maurovich-Horvat Pal , Sonawane Poonam , Francis, Ramakrishnan Rajesh , Nayak T.Soundarya , Boer Stephanie C. , Rosenberg Yves , Hamm Christian , Helm Malte , Peterson Eric , Ballantyne Christie , Calfas Karen , Champagne Mary Ann , Fleg Jerome , McCullough Peter A. , Menasche Philippe , Davidson Michael , Fremes Stephen , Guyton Robert , Mack Michael , Mohr Fred , Rao Anupama , Sabik Joe , Shapira Oz , Taggart David , Tatoulis James , Blankenship Jim , Brener Sorin , Buller Chris , Colombo Antonio , de Bruyne Bernard , Kereiakes Dean , Lefevre Thierry , Moses Jeffrey , Mahaffey Ken , Cruz-Flores Salvador , Danchin Nicholas , Feen Eli , Garcia Mario J. , Hauptman Paul , Laddu Abhay A. , Passamani Eugene , Pina Ileana L. , Simoons Maarten , Skali Hicham , Thygesen Kristian , Waters David , Endsley Patricia , Esposito Gerard , Kanters Jeffrey , Pownall John , Stournaras Dimitrios , Friedrich Matthias , Hachamovitch Rory , Oliver Dana , Harrell Frank , Blume Jeffrey , Lee Kerry , Kullo Iftikhar , McManus Bruce , Newby Kristin , Cohen David , Bugiardini Raffaele , Mattina Deirdre , Ali Ziad , Mathew Roy , Friedman Lawrence , Anderson Jeffrey , Berg Jessica , DeMets David , Michael Gibson C. , Lamas Gervasio , Deming Nicole , Himmelfarb Jonathan , Ouyang Pamela , Woodard Pamela , Nwosu Samuel , Jeffries Neal , Denaro Jean E. , Mavromichalis Stephanie , Chan Kevin , Cobb Gia , Contreras Aira , Cukali Diana , Ferket Stephanie , Gabriel Andre , Hansen Antonietta , Roberts Arline , Chang Michelle , Islam Sharder , Wayser Graceanne , Yakubov Solomon , Yee Michelle , Callison Caroline , Hogan Isabelle , Qelaj Albertina , Pirro Charlotte , Van Loo Kerrie , Wisniewski Brianna , Gilsenan Margaret , Lang Bevin , Mohamed Samaa , Esquenazi-Karonika Shari , Mathews Patenne D. , Naumova Anna , Lyo Jihyun , Setang Vincent , Xavier Mark , Anstrom Kevin , Baloch Khaula , Blount Janet , Cowper Patricia , Davidson-Ray Linda , Drew Laura , Harding Tina , David Knight J , Minshall Liu Diane , O’Neal Betsy , Redick Thomas , Nugent Karen , Jingyan Wang Grace , Goyal Abhinav , Hetrick Holly , Hayes Sean W. , Friedman John D. , James Gerlach R. , Hyun Mark , Miranda-Peats Romalisa , Slomka Piotr , Thomson Louise , Pierre Mongeon Francois , Michael Steven , Hung Judy , Zeng Xin , Eckstein Jane , Guruge Bandula , Streif Mary , Alfonso Maria A. , Corral Maria P. , Garcia Javier J. , Horst Jennifer , Jankovic Ivana , Konigstein Maayan , Lustre Mitchel B. , Peralta Yolayfi , Sanchez Raquel , Arsanjani Reza , Elmore Kimberly , Gomez Millie , Hindoyan Niree , Nakanishi Rine , Barbara Srichai-Parsia M. , Yeoh Eunice , Youn Tricia , Bianchini Francesca , Ceseri Martina , Lorimer Andrea , Magnoni Marco , Orso Francesco , Sarti Laura , Mazza Barbosa Lilian , Bello Duarte Tauane , Colaiácovo Soares Tamara , de Aveiro Morata Julia , Carvalho Pedro , de Carvalho Maffei Natalia , Egydio Flávia , Kawakami Anelise , Oliveira Janaina , Restelli Piloto Elissa , Pozzibon Jaqueline , Camara Diane , Mowafy Neamat , Spindler Caroline , Dai Hao , Feng Fang , Li Jia , Li Li , Liu Jiamin , Xie Qiulan , Zhang Haibo , Zhang Jianxin , Zhang Lihua , Zhang Liping , Zhang Ning , Zhong Hui , Escobar Claudia , Eugenia Martin Maria , Pascual Andrea , Moraga Paloma , Hernandez Victoria , Posada Maria , Fernandez Sara , Villanueva José Luis Narro , Selgas Rafael , Luyten Ann , Garcevic Nevena , Stojkovic Jelena , Ahmed Asker , Bhatt Richa , Chadha Nitika , Kumar Vijay , Lubna Sadath , Naik Pushpa , Pandey Shruti , Ramasamy Karthik , Saleem Mohammed , Sharma Pratiksha , Siddaram Hemalata 
Published: February 2025

BACKGROUND:

The appropriate use criteria for revascularization of stable ischemic heart disease have not been evaluated using randomized data. Using data from the randomized ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches; July 2012 to January 2018, 37 countries), the health status benefits of an invasive strategy over a conservative one were examined within appropriate use criteria scenarios.

METHODS:

Among 1833 participants mapped to 36 appropriate use criteria scenarios, symptom status was assessed using the Seattle Angina Questionnaire-7 at 1 year for each scenario and for each of the 6 patient characteristics used to define the scenarios. Coronary anatomy and SYNTAX(Synergy between percutaneous coronary intervention with Taxus and cardiac surgery) scores were measured using coronary computed tomography angiography. Treatment effects are expressed as an odds ratio for a better health status outcome with an invasive versus conservative treatment strategy using Bayesian hierarchical proportional odds models. Differences in the primary clinical outcome were similarly examined.

RESULTS:

The mean age was 63 years, 81% were male, and 71% were White. Diabetes was present in 28% and multivessel disease in 51%. Most clinical scenarios favored invasive for better 1-year health status. The benefit of an invasive strategy on Seattle Angina Questionnaire angina frequency scores was reduced for asymptomatic patients (odds ratio [95% credible interval], 1.16 [0.66–1.71] versus 2.26 [1.75–2.80]), as well as for those on no antianginal medications. Diabetes, number of diseased vessels, proximal left anterior descending coronary artery location, and SYNTAX score did not effectively identify patients with better health status after invasive treatment, and minimal differences in clinical events were observed.

CONCLUSIONS:

Applying the randomization scheme from the ISCHEMIA trial to appropriate clinical scenarios revealed baseline symptoms and antianginal therapy to be the primary drivers of health status benefits from invasive management. Consideration should be given to reducing the patient characteristics collected to generate appropriateness ratings to improve the feasibility of future data collection.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01471522.