bluuebunny/crossref_metadata_2025 huggingface dataset:
Science for what public? Addressing equity in American science museums and science centers
Authors: Feinstein Noah Weeth , Meshoulam David
Published: December 2013

Science museums and science centers exist (in large part) to bring science to the public. But what public do they serve? The challenge of equity is embodied by the gulf that separates a museum's actual public and the more diverse publics that comprise our society. Yet despite growing scholarly interest in museums and science centers, few researchers have explored how these organizations seek to bridge that gulf. Adopting an institutional theory perspective, we argue that equity is a field‐wide challenge in informal science education—a challenge that different organizations define and respond to in different ways. We draw on interviews with leaders from fifteen museums and science centers around the United States to examine how equity work reflects emerging norms of practice as well as local influences. Finally, we describe two institutional logics, client logic and cooperative logic, that contain different ideas about the relationship between an organization and its publics. These logics affect both the definition and the practice of equity work. The tension between them evokes a broader tension between dissemination and participation in public engagement with science. © 2013 Wiley Periodicals, Inc. J Res Sci Teach 51: 368–394, 2014
Non‐invasive prenatal testing for fetal chromosomal abnormalities by low‐coverage whole‐genome sequencing of maternal plasma DNA: review of 1982 consecutive cases in a single center
Authors: Lau T. K. , Cheung S. W. , Lo P. S. S. , Pursley A. N. , Chan M. K. , Jiang F. , Zhang H. , Wang W. , Jong L. F. J. , Yuen O. K. C. , Chan H. Y. C. , Chan W. S. K. , Choy K. W.
Published: December 2013

Objective

To review the performance of non‐invasive prenatal testing (NIPT) by low‐coverage whole‐genome sequencing of maternal plasma DNA at a single center.

Methods

The NIPT result and pregnancy outcome of 1982 consecutive cases were reviewed. NIPT was based on low coverage (0.1×) whole‐genome sequencing of maternal plasma DNA. All subjects were contacted for pregnancy and fetal outcome.

Results

Of the 1982 NIPT tests, a repeat blood sample was required in 23 (1.16%). In one case, a conclusive report could not be issued, probably because of an abnormal vanished twin fetus. NIPT was positive for common trisomies in 29 cases (23 were trisomy 21, four were trisomy 18 and two were trisomy 13); all were confirmed by prenatal karyotyping (specificity = 100%). In addition, 11 cases were positive for sex‐chromosomal abnormalities (SCA), and nine cases were positive for other aneuploidies or deletion/duplication. Fourteen of these 20 subjects agreed to undergo further investigations, and the abnormality was found to be of fetal origin in seven, confined placental mosaicism (CPM) in four, of maternal origin in two and not confirmed in one. Overall, 85.7% of the NIPT‐suspected SCA were of fetal origin, and 66.7% of the other abnormalities were caused by CPM. Two of the six cases suspected or confirmed to have CPM were complicated by early‐onset growth restriction requiring delivery before 34 weeks. Fetal outcome of the NIPT‐negative cases was ascertained in 1645 (85.15%). Three chromosomal abnormalities were not detected by NIPT, including one case each of a balanced translocation, unbalanced translocation and triploidy. There were no known false negatives involving the common trisomies (sensitivity = 100%).

Conclusions

Low‐coverage whole‐genome sequencing of maternal plasma DNA was highly accurate in detecting common trisomies. It also enabled the detection of other aneuploidies and structural chromosomal abnormalities with high positive predictive value. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd
Is it possible to individually identify red foxes from photographs?
Authors: Güthlin Denise , Storch Ilse , Küchenhoff Helmut
Published: December 2013

The individual identification of animals from photographs is increasingly used to obtain density estimates not only for animals with distinct natural markings but also for species with little or no distinct markings, such as coyotes (Canis latrans), pumas (Puma concolor) and tapirs (Tapirus terrestris). This lack of distinct natural markings may lead to large error rates in the assessment of photographs, and as a consequence result in poor abundance estimates. We conducted an experiment asking expert observers to identify individual red foxes (Vulpes vulpes) from a set of photographs taken by automatic camera‐traps. Our objectives were to determine whether reliable individual identification of red foxes from photographs is possible and, if possible, to improve the identification process. Exact assessment of error rates in individual identification can only be achieved if photographs of known individuals are available. This is rarely the case; therefore, we used photographs of red foxes from different study sites and determined the lower limit of the proportion of false positive matches. Our analysis, based on 10 expert responses, suggested that individual identification of red foxes is not reliable. The number of individual foxes assessed by the observers varied between 4 and 23 individuals. The minimal proportion of false positive matches was very large (>50% of the photographs considered to be of the same individual were from 2 different study sites) and there was little agreement among experts on which photographs showed the same individuals. Hence, we caution against individual identification from photographs of red foxes and other animals with similar or less natural markings without further testing. © 2013 The Wildlife Society.
Phases of non-extremal multi-centered bound states
Authors: Chowdhury Borun D. , Mayerson Daniel R. , Vercnocke Bert
Published: December 2013

Abstract

We investigate the phase space of multi-centered near-extremal configurations previously studied in arXiv:1108.5821 [1] and arXiv:1110.5641 [2] in the probe limit. We confirm that in general the energetically favored ground state of the multi-center potential, which can be a single or multi-center configuration, has the most entropy and is thus thermodynamically stable. However, we find the surprising result that for a subset of configurations, even though a single center black hole seems to be energetically favored, it is entropically not allowed (the resulting black hole would violate cosmic censorship). This disproves classical intuition that everything would just fall into the black hole if energetically favored. Along the way we highlight a shortcoming in the literature regarding the computation of the angular momentum coming from electromagnetic interaction in the probe limit and rectify it. We also demonstrate that static supertubes can exist inside ergoregions where ordinary point particles would be frame dragged.
Relocation Following Parental Separation: International Research, Policy and Practice
Authors: Taylor Nicola
Published: December 2013

Relocation disputes are widely regarded internationally as one of the most difficult and controversial issues in family law. This article outlines the legal context governing relocation disputes in New Zealand and briefly reviews the research literature on the impact of parental separation and relocation. The key findings are then set out from a three-year study (2007 to 2009) with 100 New Zealand families where one parent had sought to relocate with their child(ren), either within New Zealand or internationally. Interviews were conducted with 114 parents and 44 children and young people from these families about their experiences. The article concludes by traversing the efforts being made in the international legal policy context to adopt a more consistent approach to relocation disputes in common law jurisdictions.
I Wish the Views Were Clearer: Children's Wishes and Views in Australian Family Law
Authors: Campbell Alan
Published: December 2013

In 2006, legislative changes were made to the Australian Family Law Act 1975. These changes included a revision of the matters that must be considered when determining children's best interests following parental separation, at Section 60CC. This section lists two ‘primary considerations’, which relate to the child's having a ‘meaningful relationship’ with both parents and ensuring that children are safe in their interactions with their parents and others in their lives. The first of the ‘Additional considerations’ under Section 60CC concerns ‘any views expressed by the child and any factors (such as the child's maturity or level of understanding) that the court thinks are relevant to the weight it should give to the child's views’. This consideration differs from that in the pre-2006 Act, which referred to a child's ‘wishes’ rather than her/his ‘views’. There is evidence, however, that those working in the family law system may not yet have made the shift towards understanding what these changes may entail.

In this article I explore the differences between the concepts of ‘wishes’ and ‘views’ as they relate to children in family law matters. I argue that these concepts are qualitatively different, and that children's ‘views’ are far more encompassing than their ‘wishes’. Moving to a far broader understanding of children and their ability to understand issues that directly affect their lives may lead to the development of more comprehensive decisions about their futures.
Effect of fluid inertia on the dynamics and scaling of neutrally buoyant particles in shear flow
Authors: Rosén T. , Lundell F. , Aidun C. K.
Published: December 2013

The basic dynamics of a prolate spheroidal particle suspended in shear flow is studied using lattice Boltzmann simulations. The spheroid motion is determined by the particle Reynolds number (${\mathit{Re}}_{p} $) and Stokes number ($\mathit{St}$), estimating the effects of fluid and particle inertia, respectively, compared with viscous forces on the particle. The particle Reynolds number is defined by${\mathit{Re}}_{p} = 4G{a}^{2} / \nu $, where$G$is the shear rate,$a$is the length of the spheroid major semi-axis and$\nu $is the kinematic viscosity. The Stokes number is defined as$\mathit{St}= \alpha \boldsymbol{\cdot} {\mathit{Re}}_{p} $, where$\alpha $is the solid-to-fluid density ratio. Here, a neutrally buoyant prolate spheroidal particle ($\mathit{St}= {\mathit{Re}}_{p} $) of aspect ratio (major axis/minor axis)${r}_{p} = 4$is considered. The long-term rotational motion for different initial orientations and${\mathit{Re}}_{p} $is explained by the dominant inertial effect on the particle. The transitions between rotational states are subsequently studied in detail in terms of nonlinear dynamics. Fluid inertia is seen to cause several bifurcations typical for a nonlinear system with odd symmetry around a double zero eigenvalue. Particle inertia gives rise to centrifugal forces which drives the particle to rotate with the symmetry axis in the flow-gradient plane (tumbling). At high${\mathit{Re}}_{p} $, the motion is constrained to this planar motion regardless of initial orientation. At a certain critical Reynolds number,${\mathit{Re}}_{p} = {\mathit{Re}}_{c} $, a motionless (steady) state is created through an infinite-period saddle-node bifurcation and consequently the tumbling period near the transition is scaled as$\vert {\mathit{Re}}_{p} - {\mathit{Re}}_{c} {\vert }^{- 1/ 2} $. Analyses in this paper show that if a transition from tumbling to steady state occurs at${\mathit{Re}}_{p} = {\mathit{Re}}_{c} $, then any parameter$\beta $(e.g. confinement or particle spacing) that influences the value of${\mathit{Re}}_{c} $, such that${\mathit{Re}}_{p} = {\mathit{Re}}_{c} $as$\beta = {\beta }_{c} $, will lead to a period that scales as$\vert \beta - {\beta }_{c} {\vert }^{- 1/ 2} $and is independent of particle shape or any geometric aspect ratio in the flow.
Designing a more nonlinearly stable laminar flow via boundary manipulation
Authors: Rabin S. M. E. , Caulfield C. P. , Kerswell R. R.
Published: December 2013

We show how a fully nonlinear variational method can be used to design a more nonlinearly stable laminar shear flow by quantifying the effect of manipulating the boundary conditions of the flow. Using the example of plane Couette flow, we demonstrate that by forcing the boundaries to undergo spanwise oscillations in a certain way, it is possible to increase the critical disturbance energy for the onset of turbulence by 41 %. If this is sufficient to ensure laminar flow (i.e. ambient noise does not exceed this increased threshold), nearly four times less energy is consumed than in the turbulent flow which exists in the absence of imposed spanwise oscillations.
Kinetic-theory predictions of clustering instabilities in granular flows: beyond the small-Knudsen-number regime
Authors: Mitrano Peter P. , Zenk John R. , Benyahia Sofiane , Galvin Janine E. , Dahl Steven R. , Hrenya Christine M.
Published: December 2013

In this work we quantitatively assess, via instabilities, a Navier–Stokes-order (small-Knudsen-number) continuum model based on the kinetic theory analogy and applied to inelastic spheres in a homogeneous cooling system. Dissipative collisions are known to give rise to instabilities, namely velocity vortices and particle clusters, for sufficiently large domains. We compare predictions for the critical length scales required for particle clustering obtained from transient simulations using the continuum model with molecular dynamics (MD) simulations. The agreement between continuum simulations and MD simulations is excellent, particularly given the presence of well-developed velocity vortices at the onset of clustering. More specifically, spatial mapping of the local velocity-field Knudsen numbers ($K{n}_{u} $) at the time of cluster detection reveals $K{n}_{u} \gg 1$ due to the presence of large velocity gradients associated with vortices. Although kinetic-theory-based continuum models are based on a small-$Kn$ (i.e. small-gradient) assumption, our findings suggest that, similar to molecular gases, Navier–Stokes-order (small-$Kn$) theories are surprisingly accurate outside their expected range of validity.
Stabilizing effect of optimally amplified streaks in parallel wakes
Authors: Del Guercio Gerardo , Cossu Carlo , Pujals Gregory
Published: December 2013

We show that optimal perturbations artificially forced in parallel wakes can be used to completely suppress the absolute instability and to reduce the maximum temporal growth rate of the inflectional instability. To this end we compute optimal transient energy growths of stable streamwise uniform perturbations supported by a parallel wake for a set of Reynolds numbers and spanwise wavenumbers. The maximum growth rates are shown to be proportional to the square of the Reynolds number and to increase with spanwise wavelengths with sinuous perturbations slightly more amplified than varicose ones. Optimal initial conditions consist of streamwise vortices and the optimally amplified perturbations are streamwise streaks. Families of nonlinear streaky wakes are then computed by direct numerical simulation using optimal initial vortices of increasing amplitude as initial conditions. The stabilizing effect of nonlinear streaks on temporal and spatiotemporal growth rates is then determined by analysing the linear impulse response supported by the maximum amplitude streaky wakes profiles. This analysis reveals that at $\mathit{Re}= 50$, streaks of spanwise amplitude ${A}_{s} \approx 8\hspace{0.167em} \% {U}_{\infty } $ can completely suppress the absolute instability, converting it into a convective instability. The sensitivity of the absolute and maximum temporal growth rates to streak amplitudes is found to be quadratic, as has been recently predicted. As the sensitivity to two-dimensional (2D, spanwise uniform) perturbations is linear, three-dimensional (3D) perturbations become more effective than the 2D ones only at finite amplitudes. Concerning the investigated cases, 3D perturbations become more effective than the 2D ones for streak amplitudes ${A}_{s} \gtrsim 3\hspace{0.167em} \% {U}_{\infty } $ in reducing the maximum temporal amplification and ${A}_{s} \gtrsim 12\hspace{0.167em} \% {U}_{\infty } $ in reducing the absolute growth rate. However, due to the large optimal energy growths they experience, 3D optimal perturbations are found to be much more efficient than 2D perturbations in terms of initial perturbation amplitudes. Despite their lower maximum transient amplification, varicose streaks are found to be always more effective than sinuous ones in stabilizing the wakes, in accordance with previous findings.
Managing the Transition: The Role of Optimism and Self-Efficacy for First-Year Australian University Students
Authors: Morton Stephen , Mergler Amanda , Boman Peter
Published: December 2013

Students making the transition from high school to university often encounter many stressors and new experiences. Many students adjust successfully to university; however, some students do not, often resulting in attrition from the university and mental health issues. The primary aim of the current study was to examine the effects that optimism, self-efficacy, depression, and anxiety have on an individual's life stress and adaptation to university. Eighty-four first-year, full-time students from the Queensland University of Technology (60 female, 24 male) who had entered university straight from high school completed the study. Participants completed a questionnaire assessing their levels of optimism, self-efficacy, depression, anxiety, perceived level of life stress and adaptation to university. In line with predictions, results showed that optimism, depression, and anxiety each had a significant relationship with students’ perceived level of stress. Furthermore, self-efficacy and depression had a significant relationship with adaptation to university. We conclude that students with high levels of optimism and low levels of depression and anxiety will adapt better when making the transition from high school to university. In addition, students with high levels of self-efficacy and low levels of depression will experience less life stress in their commencement year of university. The implications of this study are outlined.
Red Dirt Thinking on Educational Disadvantage
Authors: Guenther John , Bat Melodie , Osborne Sam
Published: December 2013

When people talk about education of remote Aboriginal and Torres Strait Islander students, the language used is often replete with messages of failure and deficit, of disparity and problems. This language is reflected in statistics that on the surface seem unambiguous in their demonstration of poor outcomes for remote Aboriginal and Torres Strait Islander students. A range of data support this view, including the National Action Plan—Literacy and Numeracy (NAPLAN) achievement data, school attendance data, Australian Bureau of Statistics Census data and other compilations such as the Productivity Commission's biennial Overcoming Indigenous Disadvantage report. These data, briefly summarised in this article, paint a bleak picture of the state of education in remote Australia and are at least in part responsible for a number of government initiatives (state, territory and Commonwealth) designed to ‘close the gap’. For all the programs, policies and initiatives designed to address disadvantage, the results seem to suggest that the progress, as measured in the data, is too slow to make any significant difference to the apparent difference between remote Aboriginal and Torres Strait Islander schools and those in the broader community. We are left with a discourse that is replete with illustrations of poor outcomes and failures and does little to acknowledge the richness, diversity and achievement of those living in remote Australia. The purpose of this article is to challenge the ideas of ‘disadvantage’ and ‘advantage’ as they are constructed in policy and consequently reported in data. It proposes alternative ways of thinking about remote educational disadvantage, based on a reading of relevant literature and the early observations of the Cooperative Research Centre for Remote Economic Participation's Remote Education Systems project. It is a formative work, designed to promote and frame a deeper discussion with remote education stakeholders. It asks how relative advantage might be defined if the ontologies, axiologies, epistemologies and cosmologies of remote Aboriginal and Torres Strait Islander families were more fully taken into account in the education system's discourse within/of remote schooling. Based on what we have termed ‘red dirt thinking’ it goes on to ask if and what alternative measures of success could be applied in remote contexts where ways of knowing, being, doing, believing and valuing often differ considerably from what the educational system imposes.
Towards a Good Education in Very Remote Australia: Is it Just a Case of Moving the Desks Around?
Authors: Guenther John , Bat Melodie
Published: December 2013

The education system, as it relates to very remote Aboriginal and Torres Strait Islander communities in Australia, faces challenges. While considerable resources have been applied to very remote schools, results in terms of enrolments, attendance and learning outcomes have changed little, despite the effort applied. The Cooperative Research Centre for Remote Economic Participation (CRC-REP) in its Remote Education Systems (RES) project is trying to understand why this might be the case, and also attempting to identify local solutions to the ‘problem’ of very remote education. The RES project is in the process of building its research program across five remote sites in the Northern Territory, South Australia and Western Australia. As the project begins, the researchers involved have begun to consider what are the assumptions behind the ‘system’ in its current form(s). The article begins with an outline of the context of remote education in Australia within a rapidly changing global environment. However, the purpose of the article is to outline many of the assumptions built into remote education and to ask what the alternatives to these assumptions might be. The authors go on to ask questions about how a remote education system would approach some of the assumptions presented. The assumptions presented are based on a reading of the philosophical bases of education. The questions are designed to prompt a deeper discussion about how the values and worldviews of those living in very remote communities might be taken into consideration and acted upon.
A nationwide study on delirium in psychiatric patients from 1995 to 2011
Authors: Lundberg Anne Sofie , Okkels Niels , Gustafsson Lea Nørgreen , Larsen Janne Tidselbak , Sørensen Lisbeth Uhrskov , Munk-Jørgensen Povl
Published: December 2013

Objectives

Delirium shares symptoms with some mental illnesses. This may lead to misdiagnosis of delirium in psychiatric patients and a risk of inadequate management. Moreover, literature on delirium in psychiatric patients is sparse. The aim was to analyse possible changes in the diagnostic incidence of delirium in psychiatric patients from 1995 to 2011, and to investigate the patients with regard to sex, age, and type of patient.

Methods

All first time ever diagnoses of delirium among psychiatric patients were identified in the nationwide Danish Psychiatric Central Research Register (DPCRR) from 1995 to 2011. The delirium diagnoses include (1) delirium unspecified, (2) delirium with dementia, and (3) drug-related delirium, all in accordance with International Classification of Diseases-10. The incidence rates were age standardised.

Results

A total of 15 680 persons diagnosed with delirium for the first time were identified in the DPCRR between 1995 and 2011. The total incidence rate of delirium has decreased, reaching 8.4/1000 person-years in 2011. In 2011, 2.6% of the demented patients were diagnosed with delirium with dementia. Diagnosis of delirium is significantly more common in men, and the three groups of delirium showed a characteristic age distribution.

Conclusion

Our incidences were markedly lower when compared with previous studies. This suggests a possible underdiagnosis of delirium in psychiatric hospitals and should be investigated further, as delirium is a serious state and identifying the syndrome is important for sufficient treatment.
Influence of parental socio-economic status on diet quality of European adolescents: results from the HELENA study
Authors: Béghin L. , Dauchet L. , De Vriendt Tineke , Cuenca-García M. , Manios Y. , Toti E. , Plada M. , Widhalm K. , Repasy J. , Huybrechts I. , Kersting M. , Moreno L. A. , Dallongeville J.
Published: December 2013

Diet quality is influenced by socio-economic and geographical factors. The present study sought to assess whether adolescents' diet quality is affected by their parents' socio-economic status and whether the relationship between these factors is similar in northern and southern Europe. Data collected in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study in eight European countries were analysed. Dietary intake data were recorded via repeated 24 h recalls (using specifically developed HELENA Dietary Intake Assessment Tool software) and converted into an adolescent-specific Diet Quality Index (DQI-AM). Socio-economic status was estimated through parental educational level (Par-Educ-Lev) and parental occupation level (Par-Occ-Lev) as reported by the adolescents in a specific questionnaire. The DQI-AM data were then analysed as a function of Par-Educ-Lev and Par-Occ-Lev in northern European countries (Austria, Belgium, France, Germany and Sweden) and southern European countries (Greece, Italy and Spain). We studied a total of 1768 adolescents (age 14·7 (sd 1·3) years; percentage of girls: 52·8 %; 1135 and 633 subjects from northern and southern Europe, respectively). On average, the DQI-AM score was higher in southern Europe than in northern Europe (69·1 (sd 0·1) v. 60·4 (sd 2·8), respectively; P< 0·001; Δ = 12·6 %). The DQI was positively correlated with both paternal and maternal Par-Educ-Lev. However, this association was more pronounced in northern Europe than in southern Europe (P interaction = 0·004 for the mother and 0·06 for the father). The DQI was also positively correlated with Par-Occ-Lev (all P trends < 0·01), but this correlation was independent of the geographical area (P interaction = 0·51 for the mother and 0·50 for the father). In conclusion, Par-Educ-Lev and Par-Occ-Lev are associated with diet quality in adolescents in Europe. However, this association differs between northern Europe and southern Europe.
Effects of exposure to a cafeteria diet during gestation and after weaning on the metabolism and body weight of adult male offspring in rats
Authors: Mucellini Amanda Brondani , Goularte Jéferson Ferraz , de Araujo da Cunha Ana Carla , Caceres Rafael Corrêa , Noschang Cristie , da Silva Benetti Carla , Silveira Patrícia Pelufo , Sanvitto Gilberto Luiz
Published: December 2013

In the present study, we investigated whether maternal exposure to a cafeteria diet affects the metabolism and body composition of offspring and whether such an exposure has a cumulative effect during the lifetime of the offspring. Female rats were fed a control (CON) or a cafeteria (CAF) diet from their own weaning to the weaning of their offspring. At 21 d of age, male offspring were divided into four groups by diet during gestation and after weaning (CON-CON, CON-CAF, CAF-CON and CAF-CAF). Blood was collected from dams (after weaning) and pups (at 30 and 120 d of age) by decapitation. CAF dams had significantly greater body weight and adipose tissue weight and higher concentrations of total cholesterol, insulin and leptin than CON dams (Student's t test). The energy intake of CAF rats was higher than that of CON rats regardless of the maternal diet (two-way ANOVA). Litters had similar body weights at weaning and at 30 d of age, but at 120 d, CON-CAF rats were heavier. At both ages, CAF rats had greater adipose tissue weight than CON rats regardless of the maternal diet, and the concentrations of TAG and cholesterol were similar between the two groups, as were blood glucose concentrations at 30 d of age. However, at 120 d of age, CAF rats were hyperglycaemic, hyperinsulinaemic and hyperleptinaemic regardless of the maternal diet. These findings suggest that maternal obesity does not modulate the metabolism of male offspring independently, modifying body weight only when associated with the intake of a cafeteria diet by the offspring.
α-Retinol and 3,4-didehydroretinol support growth in rats when fed at equimolar amounts and α-retinol is not toxic after repeated administration of large doses
Authors: Riabroy Napaporn , Dever Joseph T. , Tanumihardjo Sherry A.
Published: December 2013

Dietary α-carotene is present in oranges and purple-orange carrots. Upon the central cleavage of α-carotene in the intestine, α-retinal and retinal are formed and reduced to α-retinol (αR) and retinol. Previous reports have suggested that αR has 2 % biopotency of all-trans-retinyl acetate due in part to its inability to bind to the retinol-binding protein. In the present work, we carried out three studies. Study 1 re-determined αR's biopotency compared with retinol and 3,4-didehydroretinol in a growth assay. Weanling rats (n40) were fed a vitamin A-deficient diet for 8 weeks, divided into four treatment groups (n10/group) and orally dosed with 50 nmol/d retinyl acetate (14·3 μg retinol), α-retinyl acetate (143 μg αR), 3,4-didehydroretinyl acetate (14·2 μg DR) or cottonseed oil (negative control). Supplementation was continued until the control rats exhibited deficiency signs 5 weeks after the start of supplementation. Body weights and AUC values for growth response revealed that αR and DR had 40–50 and 120–130 % bioactivity, respectively, compared with retinol. In study 2, the influence of αR on liver ROH storage was investigated. The rats (n40) received 70 nmol retinyl acetate and 0, 17·5, 35 or 70 nmol α-retinyl acetate daily for 3 weeks. Although liver retinol concentrations differed among the groups, αR did not appreciably interfere with retinol storage. In study 3, the accumulation and disappearance of αR over time and potential liver pathology were determined. The rats (n15) were fed 3·5 μmol/d α-retinyl acetate for 21 d and the groups were killed at 1-, 2- and 3-week intervals. No liver toxicity was observed. In conclusion, αR and didehydroretinol are more biopotent than previously reported at sustained equimolar dosing of 50 nmol/d, which is an amount of retinol known to keep rats in vitamin A balance.
Dietary l-arginine supplementation attenuates lipopolysaccharide-induced inflammatory response in broiler chickens
Authors: Tan Jianzhuang , Liu Shasha , Guo Yuming , Applegate Todd J. , Eicher Susan D.
Published: December 2013

In the present study, two experiments were conducted to investigate the effect of dietary l-arginine (Arg) supplementation on the inflammatory response and innate immunity of broiler chickens. Expt 1 was designed as a 2 × 3 factorial arrangement (n 8 cages/treatment; n 6 birds/cage) with three dietary Arg concentrations (1·05, 1·42 and 1·90 %) and two immune treatments (injection of lipopolysaccharide (LPS) or saline) given at an interval of 48 h between 14 and 21 d of age. In Expt 2, correlation between dietary Arg concentration (0·99, 1·39, 1·76, 2·13 or 2·53 %) and percentage of circulating B cells (percentage of circulating lymphocytes) was determined. In Expt 1, LPS injection decreased body-weight gain and feed intake and increased feed conversion ratio of the challenged broilers (14–21 d; P< 0·05). LPS injection suppressed (P< 0·05) the percentages of splenic CD11+ and B cells (percentages of splenic lymphocytes) and phagocytic activity of splenic heterophils and macrophages; Arg supplementation linearly decreased the percentages of CD11+, CD14+ and B cells in the spleen (P< 0·10). LPS injection increased (P< 0·05) the expression of IL-1β and IL-6 mRNA in the spleen and caecal tonsils. Arginine supplementation decreased (P< 0·05) the expression of IL-1β, Toll-like receptor 4 (TLR4) and PPAR-γ mRNA in the spleen and IL-1β, IL-10, TLR4 and NF-κB mRNA in the caecal tonsils. In Expt 2, increasing dietary Arg concentrations linearly and quadratically reduced the percentage of circulating B cells (P< 0·01). Collectively, Arg supplementation attenuated the overexpression of pro-inflammatory cytokines probably through the suppression of the TLR4 pathway and CD14+ cell percentage. Furthermore, excessive Arg supplementation (1·76 %) suppressed the percentages of circulating and splenic B cells.
Dietary phyto-oestrogens and the risk of ovarian and endometrial cancers: findings from two Australian case–control studies
Authors: Neill Annette S. , Ibiebele Torukiri I. , Lahmann Petra H. , Hughes Maria Celia , Nagle Christina M. , Webb Penelope M. ,   for the Australian Ovarian Cancer Study Group and Australian National Endometrial Cancer Study Group
Published: December 2013

Phyto-oestrogens have been suggested to have a protective effect on hormone-sensitive cancers. However, few studies have investigated the association between dietary phyto-oestrogens and gynaecological cancers. In the present study, we analysed data from two population-based case–control studies of ovarian (1366 cases and 1414 controls) and endometrial (1288 cases and 1435 controls) cancers. Dietary intake information was obtained using a 135-item FFQ, and phyto-oestrogen intake was estimated using published food composition databases. Unconditional logistic regression was used to estimate adjusted OR and 95 % CI. In multivariable analyses, there was a suggestive pattern of inverse associations between increasing intakes of total phyto-oestrogens, isoflavones and enterolignans and the risk of ovarian cancer. However, the results only reached statistical significance for the lignan compounds matairesinol and lariciresinol, where the OR for the highestv.the lowest intake category was 0·72 (95 % CI 0·54, 0·96;Pfor trend = 0·02) for matairesinol and 0·72 (95 % CI 0·55, 0·96;Pfor trend = 0·03) for lariciresinol. When the risk of ovarian cancer was assessed by subtype, there was an indication that increasing intakes of phyto-oestrogens may be associated with a decreased risk of mucinous (casesn158) ovarian tumours (OR for the highestv.the lowest intake category: 0·47 (95 % CI 0·24, 0·93);Pfor trend = 0·04). However, there were no significant associations with other histological subtypes. In contrast, dietary phyto-oestrogens (total or any subclass) were unrelated to the risk of endometrial cancer cases overall or by subtype.
EFFECT OF DEFICIT IRRIGATION ON YIELD, RELATIVE LEAF WATER CONTENT, LEAF PROLINE ACCUMULATION AND CHLOROPHYLL STABILITY INDEX OF COTTON–MAIZE CROPPING SEQUENCE
Authors: SAMPATHKUMAR T. , PANDIAN B. J. , JEYAKUMAR P. , MANICKASUNDARAM P.
Published: December 2013

Water stress induces some physiological changes in plants and has cumulative effects on crop growth and yield. Field experiments were conducted to study the effect of deficit irrigation (DI) on yield and some physiological parameters in cotton and maize in a sequential cropping system. Creation of soil moisture gradient is indispensable to explore the beneficial effects of partial root zone drying (PRD) irrigation and it could be possible only through alternate deficit irrigation (ADI) practice in paired row system of drip layout that is commonly practiced in India. In the present study, PRD and DI concepts (creation of soil moisture gradient) were implemented through ADI at two levels of irrigation using drip system. Maize was sown after cotton under no till condition without disturbing the raised bed and drip layout. Relative leaf water content (RLWC) and chlorophyll stability index (CSI) of cotton and maize were reduced under water stress. A higher level of leaf proline content was observed under severe water-stressed treatments in cotton and maize. RLWC and CSI were highest and leaf proline content was lowest in mild water deficit (ADI at 100% crop evapotranspiration once in three days) irrigation in cotton and maize. The same treatments registered higher values for crop yields, net income and benefit cost ratio for both the crops.
Feasibility of utilising an infrared-thermographic technique for early detection of subclinical mastitis in dairy camels (Camelus dromedarius)
Authors: Samara Emad M , Ayadi Moez , Aljumaah Riyadh S
Published: December 2013

Despite the proven ability of infrared thermography (IRT) technology for early detection of subclinical mastitis in dairy cows/sheep/goats, studies on its diagnostic feasibility in dairy camels are lacking. Sixty-five lactating camels in mid lactation, machine milked twice-daily and managed under intensive conditions were screened to evaluate the feasibility of utilising IRT compared with other routine indicators in detecting subclinical mastitis. Immediately before the morning milking, a portable infrared camera was used to obtain thermograms in duplicate for the front and rear left quarters to determine the udder surface temperature (UST). Thereafter, milk samples from quarters were collected, and processed for California mastitis test (CMT) score and somatic cell count (SCC). In the present study, CMT score was used to define subclinical mastitis and the feasibility of IRT to detect subclinical mastitis was compared with CMT and SCC. According to CMT score, subclinical mastitic udders had an average UST of 1·42 °C greater (P<0·0001) than healthy udders. The relationship between UST and CMT was found to be highly correlated (r=0·77;P<0·001), and UST was linearly increased as the CMT increased [UST (°C)=34·86+0·66×CMT score;R2=0·65;P<0·001]. Additionally, high correlations were obtained between UST and SCC score (r=0·75;P<0·001) and the relationship between UST and SCC was fitted best to a logarithmic equation [UST, °C=33·39+0·88×Log (SCC, ×103 cells/ml),R2=0·61,P<0·001]. The cut-off value, sensitivity, specificity and area under the receiver operating characteristics (ROC) curve for UST were 35·15 °C, 0·90, 0·98, and 0·95, respectively, when subclinical mastitis was defined according to CMT score, and were 35·70 °C, 0·89, 0·96 and 0·94, respectively, when categorised according to the obtained SCC threshold (SCC=432 000 cells/ml). In conclusion, IRT, as an indirect non-invasive screening method, was highly feasible for distinguishing subclinical mastitic udders in dairy camels, which is crucial to treat mastitis early and efficiently.
An Ecclesiastical Descent: Religion and History in the Work of William Stubbs
Authors: KIRBY J. E.
Published: December 2013

This article explores the relationship between religion and historiography in the work of the historian and bishop William Stubbs (1825–1901). Previous studies of Stubbs have neglected the High-Church influences which demonstrably pervaded his thought, and shaped his ideas of the English past, of the Christian purposes of history, and of the historical process itself. Recovering the confessional bent of Stubbs's approach to the past challenges assumptions about not only academic professionalisation, but also the prevalence through the Victorian period of a ‘Whig interpretation’ of history.
A New Anomaly: The Cross-Sectional Profitability of Technical Analysis
Authors: Han Yufeng , Yang Ke , Zhou Guofu
Published: December 2013

In this paper, we document that an application of a moving average timing strategy of technical analysis to portfolios sorted by volatility generates investment timing portfolios that substantially outperform the buy-and-hold strategy. For high-volatility portfolios, the abnormal returns, relative to the capital asset pricing model (CAPM) and the Fama-French 3-factor models, are of great economic significance, and are greater than those from the well-known momentum strategy. Moreover, they cannot be explained by market timing ability, investor sentiment, default, and liquidity risks. Similar results also hold if the portfolios are sorted based on other proxies of information uncertainty.
Bilateral sudden sensorineural hearing loss: review
Authors: Sara S A , Teh B M , Friedland P
Published: December 2013

Introduction:

Unilateral and bilateral sudden sensorineural hearing loss represent different disease entities. The unilateral condition is more common and predominantly idiopathic, and up to 65 per cent of patients spontaneously recover hearing. Conversely, the bilateral condition is rare, mostly associated with serious systemic conditions, and has a higher prevalence of morbidity and mortality.

Methods:

A literature search using the PubMed database was conducted using the MeSH terms ‘sudden’, ‘bilateral’ and ‘sensorineural hearing loss’.

Results:

One hundred and three reported cases of bilateral sudden sensorineural hearing loss were identified. The condition is most often associated with toxic, autoimmune, neoplastic and vascular conditions. A younger age of onset, with a bimodal age distribution, was seen for bilateral sudden sensorineural hearing loss, compared with the unilateral condition. Patients with the bilateral condition had more profound hearing loss, with poorer recovery and a 35 per cent mortality rate. Vestibular symptoms were also less common than in the unilateral condition.

Conclusion:

The presentation of bilateral sudden onset sensorineural hearing loss is a medical emergency requiring thorough and urgent investigation to exclude life-threatening and reversible conditions.
Spectral studies of nanosecond laser interaction with magnesium sulfate target in air
Authors: Salik Muhammad , Hanif Muhammad , Wang Jiasheng , Zhang Xi-Qing
Published: December 2013

The optical emission characterization of the plasma-assisted pulsed laser ablation of the magnesium sulfate target is discussed in this study. The emission spectrum produced by the magnesium sulfate plasma in the wavelength range 200–700 nm has been carefully investigated for different experimental conditions. The spectra analysis was performed by assuming the local thermodynamic equilibrium (LTE) approximation and calculating the plasma temperature with the Boltzmann plot method using neutral Mg spectral lines. The plasma temperature was obtained for different positions along the expansion axis, which allowed obtaining the electron population distribution as a function of the distance from the target. The plasma temperature along the expansion axis allowed evaluating the evolution of the excited states population when the plume expands. Moreover, the Stark broadening method has been employed for electron number density measurements. In this study, the Stark width of the Mg (I) spectral line at 285.21 nm was used. Besides, we have studied the variation of electron temperature (Te) and electron number density (Ne) as a function of laser irradiance.
High-informative version of nonlinear transformation of Langmuir waves to electromagnetic waves
Authors: Erofeev Vasily I.
Published: December 2013

The concept of informativeness of nonlinear plasma physical scenario is discussed. Basic principles for heightening the informativeness of plasma kinetic models are explained. Formerhigh-informative correlation analysis of plasma kinetics(Erofeev, V. 2011High-Informative Plasma Theory, Saarbrücken: LAP) is generalized for studies of weakly turbulent plasmas that contain fields of solenoidal plasma waves apart from former potential ones. Respective machinery of plasma kinetic modeling is applied to an analysis of fusion of Langmuir waves with transformation to electromagnetic waves. It is shown that the customary version of this phenomenon (Terashima, Y. and Yajima, N. 1963Prog. Theor. Phys.30, 443; Akhiezer, I. A., Danelia, I. A. and Tsintsadze, N. L. 1964Sov. Phys. JETP19, 208; Al'tshul', L. M. and Karpman, V. I. 1965Sov. Phys. JETP20, 1043) substantially distorts the picture of merging of Langmuir waves with long wavelengths (λ ≳c/ωpe).
A brief review of spatial analysis concepts and tools used for mapping, containment and risk modelling of infectious diseases and other illnesses
Authors: CAPRARELLI GRAZIELLA , FLETCHER STEPHANIE
Published: December 2013

Fast response and decision making about containment, management, eradication and prevention of diseases, are increasingly important aspects of the work of public health officers and medical providers. Diseases and the agents causing them are spatially and temporally distributed, and effective countermeasures rely on methods that can timely locate the foci of infection, predict the distribution of illnesses and their causes, and evaluate the likelihood of epidemics. These methods require the use of large datasets from ecology, microbiology, health and environmental geography. Geodatabases integrating data from multiple sets of information are managed within the frame of geographic information systems (GIS). Many GIS software packages can be used with minimal training to query, map, analyse and interpret the data. In combination with other statistical or modelling software, predictive and spatio-temporal modelling can be carried out. This paper reviews some of the concepts and tools used in epidemiology and parasitology. The purpose of this review is to provide public health officers with the critical tools to decide about spatial analysis resources and the architecture for the prevention and surveillance systems best suited to their situations.
A longitudinal follow-up study of people with Prader–Willi syndrome with psychosis and those at increased risk of developing psychosis due to genetic subtype
Authors: Larson F. V. , Whittington J. , Webb T. , Holland A. J.
Published: December 2013

Background

People with Prader–Willi syndrome (PWS), a genetically defined developmental disorder, are at increased risk of developing psychotic illness. This is particularly the case for those with a genetic subtype of PWS called maternal uniparental disomy (mUPD), where rates of psychosis are more than 60% by early adult life. Little is known about the long-term course of their disorder.

Method

Individuals who had had episodes of psychosis or were at increased risk of developing psychosis due to their genetic subtype and had taken part in a previous study were contacted. Ten people were untraceable or deceased, leaving a total of 38 potential participants. Of these, 28 agreed to take part in a follow-up interview or complete a questionnaire about their mental health and medication. This represented 20/35 (57.1%) people from the original study who had had psychosis and 8/13 (61.5%) people who were at risk due to their genetic subtype. They were thought to be representative of those groups as a whole based on IQ and number of episodes of psychosis.

Results

Two individuals had had recurrent episodes of psychosis while all others remained well. There were no new-onset cases of psychosis in those at risk. Individuals with PWS remained on high levels of psychiatric medication throughout the follow-up period.

Conclusions

Recurrent episodes of psychosis may be rare in people with PWS once stability has been achieved in the management of their illness. We speculate that this may be due to the protective influence of medication.