bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, Attitude, Practice and Psychological response toward COVID-19 among Nurses during the COVID-19 outbreak in Northern Ethiopia, 2020
Authors: Tadesse Degena Bahrey , Gebrewahd Gebremeskel Tukue , Demoz Gebre Teklemariam
Published: April 2020

Background: The Coronavirus Disease in 2019 (COVID-19) is not only the deadly outbreak disease but also it affects the mental status of the population including the nurses. Nurses play a vital role in dealing with COVID-19 victims. Nurse’s infection control measures is affected by their knowledge, attitude, practice (KAP), and psychological responses towards COVID-19. Therefore, this study was aimed to determine the knowledge, attitude, practice, and psychological response among nurses toward the COVID-19 outbreak in Northern Ethiopia. The hospital-based cross-sectional study design was employed. The data were collected from March to April 2020. Data was collected through a self-administered questionnaire.The data were entered into Epi-data manager version 4.2 and exported to SPSS 23 for analysis. Descriptive analysis was reported to describe the demographic, mean knowledge, attitude practice, and psychological response score of nurses.Results: A total of 415 nurses were participated in this study making that 100% response rate. Of the participants 241(58.1%) were female. From the 415 nurses 307(74%), 278(67%), 299(72%%), and 354(85.3%) were had good knowledge, good infection prevention practice, a favorable attitude, and disturbed psychological response towards COVID-19 respectively.
Synergistic effect of antitumor activity of doxorubicin and bicomponent nanostructures based on aluminum oxide
Authors: Bakina O. V. , Svarovskaya N. V. , Miller A. A. , Lozhkomoev A. S. , Avgustinovich A. V. , Dobrodeev А. Yu. , Spirina L. V. , Afanasyev S. G.
Published: April 2020

Introduction. There are high-thech methods of nanoparticle production with controlled morphology and physical and chemical properties. Alumina-based mesoporous nanostructures have low toxicity and biocompatibility. FDI recommends alumina for biomedical application. Alumina inhibits the grow of cancer due to positive zeta-potential and low solubility in water. We observed the synergistic effect of joint application of doxorubicin and nanostructures. This approach reduces drug concentration and its toxicity.

Purpose: to synthesize nanostructures with different surface potentials and to study toxicity of these nanostructures alone and in combination with doxorubicin.

Material and Methods. The alumina-based nanostructures were obtained by the hydrolysis of nanopowder. The morphology of nanostructures was investigated by transmission electron microscopy with an integrated system of energy dispersive analysis. The phase composition of the particles was determined by x-ray diffraction. The effect of the synthesized nanostructures on the viability of cell lines was determined using the MTT test.

Results. The synthesized nanostructures have a low toxicity and can be used as an adjuvant for doxorubicin.

Conclusion. The combined use of doxorubicin and bicomponent nanostructures leads to an increase in the damaging effect of doxorubicin on Neuro-2a cells.
Extracting household water use event characteristics from rudimentary data
Authors: Meyer Bettina Elizabeth , Jacobs Heinz Erasmus , Ilemobade Adeshola
Published: April 2020

Household water end-uses have been extracted from high-resolution smart water meter data in various earlier studies. However, research on end-use disaggregation from rudimentary data is limited. Rudimentary data is defined as data recorded in intervals longer than 1 min, or data recorded with resolutions larger than 0.1 L/pulse. Developing countries typically deal with rudimentary data, due to the high cost and high resource investment associated with high-resolution data. The aim of this study was to extract useful event characteristics from rudimentary data, without identifying the actual end-uses per se. A case study was conducted in the City of Johannesburg, South Africa, where 63 homes were equipped with iPERL smart water meters. The meters recorded flow measurements every 15 s at a 1 L/pulse resolution, rendering the recorded data rudimentary. A total of 1,107,547 event pulses were extracted over the 217-day study period. Although the method presented is limited in the sense that water use events cannot be identified, the method allows for disaggregation of event pulses in the presence of rudimentary data. Using this tool, it is possible to lift valuable information from rudimentary data that would subsequently benefit service providers in setting water demand strategies.
Experimental and numerical study of flood dynamics in a river-network-floodplain set-up
Authors: Mali Vijay Kisan , Veeranna B. , Parik Aditya , Kuiry Soumendra Nath
Published: April 2020

Flood simulations demand mathematical models, which are rigorously calibrated and validated against benchmarking datasets. For this purpose, experiments are conducted in a river-network-floodplain set-up. Hypothetical stepped hydrographs are passed through the channel-network, and fluvial flooding situations are created. Flood depths are recorded at various locations and evolving flood extents are extracted by image processing. TELEMAC 2D is tested against the observed data. The most accurate scheme for flood prediction is identified through sensitivity analysis. Inclusion of the turbulence model is found to improve the accuracy in predicting dynamic flood extents. The model seems to slightly overpredict inundation extents during the rising limb of the hydrographs and underpredict during the falling limb. In addition, certain aspects of a flood such as river–floodplain interaction and junction hydraulics cannot be reproduced with high precision by the 2D model. The experimental datasets can be a valuable resource to mathematical modellers and are freely downloadable.
Development and Correction of Tactile Perception in Children with Cerebral Palsy using the elements of Su Jokj Therapy
Authors: Tokareva Olga Nikolaevna
Published: April 2020

The article presents an individual form of work with children with disabilities (cerebral palsy), which takes into account the individual characteristics of each child and joint activities with parents. The positive dynamics is described when using tactile sensation development classes with elements of su Jok therapy (massage ring, roller and ball).
Bilingüismo y desplazamiento del español. Notas sobre el caso de Tijuana, B. Cfa.
Authors: Gavaldón de Barreto Lourdes
Published: April 2020

Nos proponemos efectuar un estudio poniendo en práctica los recursos que ha aportado la sociolingüística en los últimos años para conocer y describir con mayor objetividad la relación de lenguas en contacto que se desarrolla en Tijuana. Tomando lo anterior como base, esta investigación proporcionará una visión de conjunto sobre los principales mecanismos que entran en juego, los que determinan la tendencia a seguir, los que indican los cambios cualitativos en los procesos, y sobre todo, la relación que guardan entre ellos. De esta manera, será posible conocer la interacción de los factores económicos, políticos, sociales y culturales que influyen en la realización lingüística, así como determinar los niveles de la lengua: fonológico, morfológico, sintáctico así como el léxico. Con ello la comunicación verbal se convierte en un indicador que permite identificar los factores sociales que predominan y condicionan los cambios.
El lenguaje como elemento cultural de identidad social en la zona fronteriza del norte de México
Authors: Rodríguez Sala-Gómezgil Ma. Luisa
Published: April 2020

Este ensayo sociolingüístico nos expone que en cualquiera de las formas en que se exprese el lenguaje, su función es eminentemente social y por lo tanto, ligada a lo cultural. El bilingüismo, para que tenga sentido social, deberá ser estudiado en relación con el contexto y mediante la distinción de varios dominios en los cuales es apropiado cierto comportamiento y tomando en cuenta, entre otros elementos: el ambiente familiar, de trabajo y de transacciones comerciales. Los diversos matices del bilingüismo están estrechamente vinculados a la interacción natural que implica vivir a lo largo de las fronteras entre comunidades lingüísticas diferentes. La importancia cultural se manifiesta en el uso evidente del propio grupo social que comparten el idioma común, en nuestro caso, el español.
Las reformas a la inmigración y su impacto en la frontera México-Estados Unidos
Authors: Fernández Raúl
Published: April 2020

El presente trabajo es una reflexión sobre el impacto que las reformas de las leyes de inmigración han ejercido sobre la economía de la frontera de México en los últimos 20 años. El rápido crecimiento de esta economía, desde el cierre del Programa de Braceros a principios de los sesentas, ha sido guiado por fuerzas externas provenientes de Estados Unidos. Por su parte, en un principio el gobierno de los Estados Unidos prestó poca atención al cumplimiento de las leyes de migración establecidas ante la migración masiva de trabajadores mexicanos indocumentados hacia el sur de California. Este artículo desglosa algunos argumentos que explican los cambios que ha sufrido la migración en cuanto a los grupos étnicos que la conforman, los lugares con mayor oferta de trabajo y las propuestas de reforma a la inmigración como resultado del creciente flujo migratorio.
Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies
Authors: Kumar Pradeep , Kamle Madhu , Mahato Dipendra K. , Bora Himashree , Sharma Bharti , Rasane Prasad , Bajpai Vivek K.
Published: April 2020

Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines
throughout India since ancient times. All the parts of the plant are immensely useful due to the presence
of different compounds of pharmaceutical importance belonging to various groups as alkaloids,
diterpenoid lactones, glycosides, steroids, sesquiterpenoid, and phenolics. These compounds possess
pharmacological properties, which make it anti-diabetic, antipyretic, anti-inflammatory, anti-oxidant,
hepato-protective, and immuno-modulatory. However, due to the increasing population, there is an inadequate
supply of drugs. Therefore, this review focuses on phytochemistry, ethnopharmacology, clinical
application and its conservation strategies so that the plant can be conserved for future generations
and utilized as alternative medicine as well as to design various pharmacologically important drugs.
Protective Effects of Cocos Nucifera Oil in Paraphenylene Diamine Toxicity
Authors: Arafa El-Shaimaa A. , Buabeid Manal A. , Hassan Waseem , Murtaza Ghulam , Chohan Tahir A. , Ahmed Hammad
Published: April 2020

Background:

Paraphenylenediamine (PPD) is a highly toxic compound used for hair-dyeing
worldwide. PPD self-poisoning had significantly increased in recent times with increased mortality rates.

Objective:

This study aims to evaluate the toxic effects of PPD and the protective potential of its prospective
antidote Virgin Coconut Oil (Cocos nucifera).

Methods:

PPD was identified and validated by FT-IR and UV mass spectrometer. PPD toxicity was
induced in-vivo by single intraperitoneal injection (40 mg/kg and 60 mg/kg). Single-injection of Virgin
Coconut Oil (VCO) was administered in the presence of PPD at doses of 5 mg/kg and 10 mg/kg. Blood
was analyzed for renal, hepatic and cardiac biomarkers. Relevant organs were collected, weighed and
preserved for histopathological examination. Statistical analysis was carried out to note mortality rate,
survival duration and serum biochemical parameter. Molecular docking studies were performed to assess
attachment of PPD with histaminergic receptors.

Results:

PPD injection achieved 100% mortality rate with short survival span, and disturbed hepatic,
renal, and cardiac serum markers with marked histopathological changes. VCO notably decreased mortality
rate, raised treatment time window with marked adjustment in hepatic, renal, and cardiac markers.
Docking studies proved that PPD attaches robustly with histaminergic receptors.

Conclusion:

The study concludes that VCO possesses lifesaving protection against PPD toxicity and
can be a suitable antidote.
Management Perspective of Wilson’s Disease: Early Diagnosis and Individualized Therapy
Authors: Yuan Xiang-Zhen , Yang Ren-Min , Wang Xiao-Ping
Published: April 2020

Wilson’s disease (WD) is an inherited disease caused by mutations in ATP7B and is
characterized by the pathological accumulation of copper in the liver and brain. Common clinical
manifestations of WD include a wide range of liver disease and neurological symptoms. In some
patients, psychiatric symptoms may be the only manifestation at the time of diagnosis. The clinical
features of WD are highly variable and can mimic any disease of internal medicine. Therefore, for
unexplained medical diseases, the possibility of WD should not be ignored. Early diagnosis and
treatment can improve the prognosis of WD patients and reduce disability and early death. Gene
sequencing is becoming a valuable method to diagnose WD, and if possible, all WD patients and
their siblings should be genetically sequenced. Copper chelators including D-penicillamine, trientine,
and dimercaptosuccinic acid can significantly improve the liver injury and symptoms of WD
patients but may have a limited effect on neurological symptoms. Zinc salts may be more appropriate
for the treatment of asymptomatic patients or for the maintenance treatment of symptomatic
patients. High-quality clinical trials for the drug treatment of WD are still lacking, therefore, individualized
treatment options for patients are recommended. Individualized treatment can be determined
based on the clinical features of the WD patients, efficacy and adverse effects of the drugs,
and the experience of the physician. Liver transplantation is the only effective method to save patients
with acute liver failure or with severe liver disease who fail drug treatment.
Targeting the Endocannabinoid System in Borderline Personality Disorder: Corticolimbic and Hypothalamic Perspectives
Authors: Ferber Sari G. , Hazani Reut , Shoval Gal , Weller Aron
Published: April 2020

Borderline Personality Disorder (BPD) is a chronic debilitating psychiatric disorder
characterized mainly by emotional instability, chaotic interpersonal relationships, cognitive disturbance
(e.g., dissociation and suicidal thoughts) and maladaptive behaviors. BPD has a high rate of
comorbidity with other mental disorders and a high burden on society. In this review, we focused
on two compromised brain regions in BPD - the hypothalamus and the corticolimbic system, emphasizing
the involvement and potential contribution of the endocannabinoid system (ECS) to improvement
in symptoms and coping. The hypothalamus-regulated endocrine axes (hypothalamic
pituitary – gonadal, thyroid & adrenal) have been found to be dysregulated in BPD. There is also
substantial evidence for limbic system structural and functional changes in BPD, especially in the
amygdala and hippocampus, including cortical regions within the corticolimbic system. Extensive
expression of CB1 and CB2 receptors of the ECS has been found in limbic regions and the hypothalamus.
This opens new windows of opportunity for treatment with cannabinoids such as cannabidiol
(CBD) as no other pharmacological treatment has shown long-lasting improvement in the
BPD population to date. This review aims to show the potential role of the ECS in BPD patients
through their most affected brain regions, the hypothalamus and the corticolimbic system. The literature
reviewed does not allow for general indications of treatment with CBD in BPD. However,
there is enough knowledge to indicate a treatment ratio of a high level of CBD to a low level of
THC. A randomized controlled trial investigating the efficacy of cannabinoid based treatments in
BPD is warranted.
Punica granatum as a Source of Natural Antioxidant and Antimicrobial Agent: A Comprehensive Review on Related Investigations
Authors: Jalali Atefeh , Kiafar Mohammadreza , Seddigh Masih , Zarshenas Mohammad M.
Published: April 2020

Background:

The consumption of natural antioxidants is increasing due to the demand
and tendency to natural foods. Punica granatum L. [Punicaceae] is a fruit with various bioactive
ingredients. The effectiveness of this plant has been proved against various disorders such as hyperglycemia,
hyperlipidemia, blood coagulation, infections, cancer, and dentistry. Among them,
there are numerous researches on antimicrobial and antioxidant properties. Subsequently, the present
study aimed to compile a review of those properties to outline this herb as a possible natural
antioxidant and preservative.

Methods:

Synchronically, keywords "Punica granatum" with antimicrobial, or antibacterial, antifungal,
antiviral, antioxidant and radical scavenging were searched through "Scopus" database up
to 31st September 2019. Papers focusing on agriculture, genetics, chemistry, and environmental
sciences were excluded, and also related papers were collected.

Results:

Among 201 papers focusing on related activities, 111 papers have dealt with antioxidant
activities focusing based on DPPH assay, 59 with antibacterial, on both gram+ and gram- bacteria,
24 with antifungal effects, mostly on Aspergillus niger and Candida albicans, and 7 papers with
antiviral activities. There were about 50 papers focusing on in-vivo antioxidant activities of this
plant.

Conclusion:

Taken together, botanical parts of P. granatum have possessed notable radical scavenging
and antimicrobial activities that, with these properties, this plant can be introduced as a
natural, safe source of preservative and antioxidant. Accordingly, P. granatum can be applied as
excipient with the aforementioned properties in the pharmaceutical and food industries.
Progress in Benzimidazole/Benzimidazolium-Derived Supramolecular Gelators in Ion Recognition
Authors: Panja Santanu , Ghosh Kumaresh
Published: April 2020

The benzimidazole moiety, being a versatile heterocyclic unit, finds potential utility in
multiple applications ranging from material science to medicinal chemistry. Benzimidazole derivatives
are widely chosen as a multifunctional unit for the synthesis of bioactive organic compounds
because of their structural similarities to the natural nucleotides. They are also used as heteroaromatic
scaffolds in molecular probes for sensing and bio-imaging. Amphoteric nature of the benzimidazole
ring forms the basis of designing new fluorescent architectures for various metal ions, anions, nitroaromatics
as well as neutral organic molecules. Alongside, recent years have also witnessed the
emerging development of benzimidazole-based supramolecular gels, useful in sensing and water purification.
Supramolecular gels are a special class of self-assembled structures formed by weak noncovalent
interactions between the molecules and are easily tuned by external stimuli. Such stimuliresponsive
gels serve as smart materials because of their abilities to undergo gel-to-gel, or gel-to-sol
transition upon subtle change of the gel environment. Of various stimuli, ion coordination draws attention
for their visual detection and to adapt material properties. The ion-sensitive gels act as
fascinating biomaterials with potential applications in drug delivery, optoelectronics and catalysis.
Thus, designing of such ion-responsive gels is challenging. The rising popularity of benzimidazole
based-gels is related to its advanced properties such as π-bridging, hydrogen bonding, fluorescence
and ion coordinating abilities. This review focuses on recently developed various ion-responsive
benzimidazole motif-based supramolecular gelators by summarising the crucial role of the structural
parameters of benzimidazole gelators. Beside ion sensing, we also desire to summarize other possible
applications of gelators in material chemistry. Finally, the necessity and possibility of further exploration
of benzimidazole/ benzimidazolium derived gelators are briefly described.
The Influence of Calcination on the Physicochemical Properties of Acidactivated Natural Mordenite
Authors: Lycourghiotis Sotiris , Makarouni Dimitra , Kordouli Eleana , Bourikas Kyriakos , Kordulis Christos , Dourtoglou Vassilis
Published: April 2020

The influence of air–calcination (500oC for 2h) on the physicochemical properties of natural
mordenite and mordenite activated by aqueous solutions of several acids, has been studied through
various methods. Calcination does not affect the crystal structure of the samples and their fibrous and
pores morphology. In contrast, it causes a drastic decrease in the high Bronsted acidity of the acidactivated
samples, which was tentatively attributed to the partial destruction of the very strong Al–
(OH)–Si acid sites. The influence of calcination on the texture is different depending on the acidic solution
used for mordenite activation. The high specific surface area and the moderate acidity obtained
after calcination of the sample activated by HCl render this material quite attractive support for the
development of nickel supported catalysts for green diesel production.
Current Overview of Inorganic Nanoparticles for the Treatment of Central Nervous System (CNS) Diseases
Authors: Persano Francesca , Leporatti Stefano
Published: April 2020

:

Although the integrity of the Blood-brain Barrier (BBB) is often
compromised in several Central nervous system (CNS) disorders, the release of
therapeutic or diagnostic agents in the brain remains challenging. Indeed, most of
the currently established diagnostic and therapeutic protocols result ineffective in
treating and detecting CNS diseases. In this context, it is essential to develop novel
strategies that allow a targeted release of the therapeutic agents to the brain,
overcoming the BBB. The technological advances of the last decade have led to the
development of new techniques for nanoscale treatment and diagnosis of brain
diseases.

:

Several nano-formulations have been recently proposed and successfully tested in
preclinical models for their capacity to cross the BBB, in particular when
chemically modified with the intent to exploit specific transport processes that
normally occur at the interface between blood and endothelium of the cerebral
vasculature.

:

In this review, the tunable physico-chemical characteristics of inorganic
nanoparticles will be reviewed, and how this aspect can offer the possibility to
improve current therapeutic strategies. The local and systemic toxicity of these
nanomaterials will be also analyzed. Furthermore, we will provide an update on
recent key advancements in the design and synthesis of novel inorganic core-lipid
shell nanoparticles for the treatment of CNS disorders, and how these vectors may
overcome challenges faced by current inorganic nanomaterials.
Korelasi Indeks Massa Tubuh dan Kadar Albumin dengan Konversi Sputum Pasien Tuberkulosis
Authors: Sari Dina Keumala , Mega Juli Yosa , Harahap Juliandi
Published: April 2020

Abstrak Tuberkulosis (TB) masih menjadi masalah utama kesehatan di Indonesia termasuk di Propinsi Sumatera Utara. Telah dilaporkan efikasi yang baik dari pengobatan TB di berbagai daerah, keberhasilan pengobatan TB dipengaruhi oleh banyak factor termasuk status nutrisi. Penelitian ini bertujuan untuk menemukan adanya hubungan indeks massa tubuh dan albumin dengan konversi sputum pasien tuberculosis, khususnya pasien tuberculosis paru positif kuman Basil Tahan Asam. Penelitian ini dilaksanakan di dua Pusat Kesehatan Masyarakat di Kota Medan antara bulan Oktober dan Nopember 2018. Seluruh subjek penelitian sejumlah 39 pasien TB dengan positif kuman Basil Tahan Asam ikut serta. Subjek penelitian menerima pengobatan TB sesuai panduan. Indeks masa tubuh, albumin, dan sputum diukur dengan menggunakan stature meter dan timbangan digital. Proporsi subjek penelitian di bawah normal, normal dan di atas normal adalah 13 (33.3%), 21 (53.9%) and 5 (12.8%), berturut-turut. Kadar albumin termasuk kadar normal ditemukan pada 25 subjek penelitian (64.1%), dan selebihnya termasuk kategori rendah. Indeks massa tubuh normal berhubungan bermakna dengan peningkatan kadar albumin (p<0.05). setelah dua bulan pemantuan terlihat konversi sputum berhubungan bermakna dengan nilai indeks massa tubuh yang normal dan atau kadar albumin yang normal (p<0.05). Simpulan yang didapat adalah status nutrisi adalah faktor penting dalam pengobatan TB.Kata kunci: albumin, Indonesia, indeks massa tubuh, konversi sputum, tuberculosisÂ Abstract Â Tuberculosis (TB) remains a major public issue in Indonesia including in North Sumatra province. Despite reported good efficacy of TB treatment in the region, the success of treatment depends on many factors including nutritional status. This study aims to determine the relationship between Body Mass Index and Albumin level with sputum conversion in AFB-positive pulmonary TB patients.The study was done in two primary health centres in Medan between October and November 2018. A total of 39 newly diagnosed TB patients with confirmed AFB-positve were included in the study.Participants received TB treatment according to the national guidelines. Body mass index, albumin, and sputum were measured using a stature meter and a digital scale.The proportion of participants with below normal, normal and above normal BMI status were 13 (33.3%), 21 (53.9%) and 5 (12.8%), respectively. Level of albumin was determined as normal in 25 participants (64.1%), and the remaining as low. Normal BMI status was significantly associated with increased albumin level (p<0.05). At 2 months follow-up, the sputum conversion was observed in 24 individuals (61.5%), and the conversion was significantly associated with normal BMI and/or normal albumin level (p<0.05). We concluded that nutritional status is an important factor in the success of TB treatment. Keywords: albumin, body mass index, sputum conversion, tuberculosis, Indonesia
Caracterización del modelo nacional de vigilancia comunitaria por cuadrantes en Bogotá desde un enfoque sistémico
Authors: Paez Murillo Carlos Augusto , Sandoval Garrido Luis Eduardo , Peón Escalante Ignacio Enrique
Published: April 2020

Este artículo diagnostica el funcionamiento en la ciudad de Bogotá del Modelo Nacional de Vigilancia Comunitaria por Cuadrantes, una estrategia de control territorial aplicada por la Policía Nacional de Colombia. Para ello, desde un enfoque sistémico, se recurre al modelo de sistema viable y a la metodología de autotransformación. Mediante entrevistas no estructuradas a agentes de policía retirados, además de la consulta de fuentes secundarias, se siguieron cuatro pasos: identidad, definición de niveles de organización recursiva, estrategia estructural y diagnóstico. Los resultados muestran que el modelo promueve un servicio policial inclusivo y flexible, con una estructura específica de procesos primarios, roles, mecanismos y niveles, que facilita una mejor comprensión de las interacciones de la comunidad y, en últimas, mejores resultados en los objetivos institucionales de seguridad y convivencia.
Effects of Sharing Old Pictures With Grandchildren on Intergenerational Relationships: Protocol for a Randomized Controlled Trial
Authors: Gantumur Zoljargalan , Baez Marcos , Ulamnemekh Nomin-Erdene , Ibarra Francisco , Myagmarjav Sugarmaa , Casati Fabio
Published: April 2020

Background

Intergenerational relationships are beneficial for both grandparents and grandchildren. A positive grandparent-grandchild relationship can improve the psychological well-being of older adults and be a source of social support, family history, and identity development. Maintaining meaningful interactions can be, however, a challenging endeavor, especially as life events lead to relocating geographically. Grandparents and grandchildren can have different preferences in terms of communication mediums and different assumptions about the real conversational needs of the other.

Objective

In this study, we will investigate the feasibility and effect of sharing memories of older adults with their grandchildren in social media. This intervention focuses on bringing snippets of the lives of the grandparents into the grandchildren’s social media feed and analyzing the potential effect on relational quality, relational investment, and conversational resources from the perspective of the grandchildren.

Methods

A randomized controlled trial will be used to measure the effectiveness of sharing family memories through social media on intergenerational relationships from the perspective of the grandchildren. The study will be implemented in Mongolia among 60 grandparent-grandchild pairs who will be assigned to either a control or intervention group. Pictures and stories will be collected during reminiscence sessions between the researchers and the grandparents before the intervention. During an intervention period of 2 months, grandchildren in the intervention group will receive pictures and stories of their grandparents on their social media account. Pre- and postintervention questionnaires will measure relationship quality, relationship investment, and conversational resources and will be used to assess the effectiveness of the intervention.

Results

We conducted a pretest pilot from January to April 2018 among 6 pairs of participants (6 grandparents and 6 grandchildren). The validation of the protocol was focused on the process, instruments, and technological setup. We continued the study after the validation, and 59 pairs of participants (59 grandparents and 59 grandchildren) have been recruited. The data collection was completed in November 2019.

Conclusions

The results of this study will contribute to strategies to stimulate social interactions in intergenerational pairs. A validation of the study process is also presented to provide further operational recommendations. The lessons learned during the validation of the protocol are discussed with recommendations and implications for the recruitment, reminiscence sessions, technological setup, and administration of instruments.

International Registered Report Identifier (IRRID)

DERR1-10.2196/16315
Developing Effective Methods for Electronic Health Personalization: Protocol for Health Telescope, a Prospective Interventional Study
Authors: Willemse Bastiaan Johannes Paulus Cornelis , Kaptein Maurits Clemens , Hasaart Fleur
Published: April 2020

Background

Existing evaluations of the effects of mobile apps to encourage physical activity have been criticized owing to their common lack of external validity, their short duration, and their inability to explain the drivers of the observed effects. This protocol describes the setup of Health Telescope, a longitudinal panel study in which the long-term effects of mobile electronic health (eHealth) apps are investigated. By setting up Health Telescope, we aim to (1) understand more about the long-term use of eHealth apps in an externally valid setting, (2) understand the relationships between short-term and long-term outcomes of the usage of eHealth apps, and (3) test different ways in which eHealth app allocation can be personalized.

Objective

The objectives of this paper are to (1) demonstrate and motivate the validity of the many choices that we made in setting up an intensive longitudinal study, (2) provide a resource for researchers interested in using data generated by our study, and (3) act as a guideline for researchers interested in setting up their own longitudinal data collection using wearable devices. For the third objective, we explicitly discuss the General Data Protection Regulation and ethical requirements that need to be addressed.

Methods

In this 4-month study, a group of approximately 450 participants will have their daily step count measured and will be asked daily about their mood using experience sampling. Once per month, participants will receive an intervention containing a recommendation to download an app that focuses on increasing physical activity. The mechanism for assigning recommendations to participants will be personalized over time, using contextual data obtained from previous interventions.

Results

The data collection software has been developed, and all the legal and ethical checks are in place. Recruitment will start in Q4 of 2020. The initial results will be published in 2021.

Conclusions

The aim of Health Telescope is to investigate how different individuals respond to different ways of being encouraged to increase their physical activity. In this paper, we detail the setup, methods, and analysis plan that will enable us to reach this aim.

International Registered Report Identifier (IRRID)

PRR1-10.2196/16471
Self-Practice of Stabilizing and Guided Imagery Techniques for Traumatized Refugees via Digital Audio Files: Qualitative Study
Authors: Zehetmair Catharina , Nagy Ede , Leetz Carla , Cranz Anna , Kindermann David , Reddemann Luise , Nikendei Christoph
Published: April 2020

Background

Refugees have an increased risk of developing mental health problems. There are insufficient psychosocial care structures to meet the resulting need for support. Stabilizing and guided imagery techniques have shown promising results in increasing traumatized refugees’ emotional stabilization. If delivered via audio files, the techniques can be practiced autonomously and independent of time, space, and human resources or stable treatment settings.

Objective

This study aimed to evaluate the self-practice of stabilizing and guided imagery techniques via digital audio files for traumatized refugees living in a reception and registration center in Germany.

Methods

From May 2018 to February 2019, 42 traumatized refugees participated in our study. At T1, patients received digital audio files in English, French, Arabic, Farsi, Turkish, or Serbian for self-practice. Nine days later, at T2, a face-to-face interview was conducted. Two months after T2, a follow-up interview took place via telephone.

Results

At T2, about half of the patients reported the daily practice of stabilizing and guided imagery techniques. At follow-up, the average frequency of practice was once weekly or more for those experiencing worse symptoms. No technical difficulties were reported. According to T2 and follow-up statements, the techniques helped the patients dealing with arousal, concentration, sleep, mood, thoughts, empowerment, and tension. The guided imagery technique “The Inner Safe Place” was the most popular. Self-practice was impeded by postmigratory distress factors, like overcrowded accommodations.

Conclusions

The results show that self-practice of stabilizing and guided imagery techniques via digital audio files was helpful to and well accepted by the assessed refugees. Even though postmigratory distress factors hampered self-practice, “The Inner Safe Place” technique was particularly well received. Overall, the self-practiced audio-based stabilizing and guided imagery techniques showed promising results among the highly vulnerable group of newly arrived traumatized refugees.
Perceptions About Technologies That Help Community-Dwelling Older Adults Remain at Home: Qualitative Study
Authors: Verloo Henk , Kampel Thomas , Vidal Nicole , Pereira Filipa
Published: April 2020

Background

The population of Europe is aging rapidly. Most community-dwelling older adults (CDOAs) want to remain in their homes, particularly those experiencing functional decline. Politicians and academics repeatedly praise technological instruments for being the preferred solution for helping older adults with deteriorating health to remain at home.

Objective

This study aimed to understand the perceptions of CDOAs and their informal caregivers (ICs) and professional caregivers (PCs) about technologies that can help keep older adults at home.

Methods

This qualitative study used personal interviews, focus groups, and photo-elicitation interviews to better understand the perceptions of a convenience sample of 68 CDOAs, 21 ICs, and 32 PCs.

Results

A fraction of CDOAs did not perceive technological instruments to be a very useful means of helping them remain at home. However, the ICs and PCs were more positive. The CDOAs preferred and were more willing to adopt technologies related to their mobility and safety and those that would help slow down their cognitive decline. The ICs preferred technological aids that assist in the activities of daily living as well as safety-related technologies for detecting falls and helping to locate disoriented older adults. The PCs preferred integrated communication and information systems to improve collaboration between all stakeholders, housing equipped with technologies to manage complex care, high-performance ancillary equipment to transfer people with reduced mobility, and surveillance systems to ensure safety at home.

Conclusions

Although our study reports that CDOAs have limited interest in innovative technologies to help them remain at home, their technological skills will undoubtedly improve in the future, as will those of ICs and PCs. Technological tools will play an increasingly important role in home health care.
Adherence of the #Here4U App – Military Version to Criteria for the Development of Rigorous Mental Health Apps
Authors: Linden Brooke , Tam-Seto Linna , Stuart Heather
Published: April 2020

Background

Over the past several years, the emergence of mobile mental health apps has increased as a potential solution for populations who may face logistical and social barriers to traditional service delivery, including individuals connected to the military.

Objective

The goal of the #Here4U App – Military Version is to provide evidence-informed mental health support to members of Canada’s military community, leveraging artificial intelligence in the form of IBM Canada’s Watson Assistant to carry on unique text-based conversations with users, identify presenting mental health concerns, and refer users to self-help resources or recommend professional health care where appropriate.

Methods

As the availability and use of mental health apps has increased, so too has the list of recommendations and guidelines for efficacious development. We describe the development and testing conducted between 2018 and 2020 and assess the quality of the #Here4U App against 16 criteria for rigorous mental health app development, as identified by Bakker and colleagues in 2016.

Results

The #Here4U App – Military Version met the majority of Bakker and colleagues’ criteria, with those unmet considered not applicable to this particular product or out of scope for research conducted to date. Notably, a formal evaluation of the efficacy of the app is a major priority moving forward.

Conclusions

The #Here4U App – Military Version is a promising new mental health e-solution for members of the Canadian Armed Forces community, filling many of the gaps left by traditional service delivery.
Telemedicine During the COVID-19 Pandemic: Experiences From Western China
Authors: Hong Zhen , Li Nian , Li Dajiang , Li Junhua , Li Bing , Xiong Weixi , Lu Lu , Li Weimin , Zhou Dong
Published: April 2020

Disasters and pandemics pose unique challenges to health care delivery. As health care resources continue to be stretched due to the increasing burden of the coronavirus disease (COVID-19) pandemic, telemedicine, including tele-education, may be an effective way to rationally allocate medical resources. During the COVID-19 pandemic, a multimodal telemedicine network in Sichuan Province in Western China was activated immediately after the first outbreak in January 2020. The network synergizes a newly established 5G service, a smartphone app, and an existing telemedicine system. Telemedicine was demonstrated to be feasible, acceptable, and effective in Western China, and allowed for significant improvements in health care outcomes. The success of telemedicine here may be a useful reference for other parts of the world.
OTEL ÇALIŞANLARININ İŞ TANIMLARI KONUSUNDAKİ FARKINDALIKLARI ÜZERİNE BİR ARAŞTIRMA
Authors: TÜRKAY Oğuz , EREN Murat
Published: April 2020

Amaç: Otel çalışanlarının yeterli ve net iş tanımları ile yönlendirilmeleri İKY bölümlerinin verimliliğini artırmakta, çalışanın ve işletmenin performansına etki etmektedir. Bu çalışma otel işgörenlerinin iş tanımlarını bilme durumlarını çok boyutlu bir perspektiften incelemeyi amaçlamaktadır. Yöntem: Nitel yönteme uygun olarak, açık uçlu sorulardan oluşan bir form aracılığıyla 166 çalışandan veri elde edilmiştir. Analiz aşamasında karma yönteme uygun davranılmıştır. Bulgular: Otel çalışanlarının önemli bir kısmının iş tanımı kavramını bilmediği, daha büyük kısmının ise kendi iş tanımını da bilmediği tespit edilmiştir. İş tanımı kavramını bilmeyenlerle kendi iş tanımını bilmeyenler önemli oranda aynı kişilerdir. Dolayısıyla, iş tanımını bilmeme hem kişisel hem de işletmelerde İKY uygulamalarının eksikliği ile ilgili olabilir. Çalışanlar, işletmelerinin kendilerinden beklentilerini müşteri odaklı bir bakışla anlamlandırmaktadır. En kritik iş gereklilikleri olarak iletişim becerisi ve yabancı dil öne çıkmaktadır. İşlerinin en sevilen yanı olarak iletişim ve en sevilmeyen yanı olarak müşterinin olumsuz tutumları beyan edilmektedir. İşletmeleri için oynadıkları en kritik roller ise müşteri memnuniyeti sağlamak ve iç süreçler-rutinin takibi olarak algılanmaktadır.Sonuç: Otel İKY yetkililerinin iş tanımları konusundaki belirsizliği gidermesi gerekmektedir. İş tanımları netleştirilmeli, çalışanların kendi iş tanımlarını bilmesi sağlanmalıdır. İKY süreçlerinin hayata geçirilmesinde otellerdeki iş yoğunluğunun engelleyici özelliği ile baş edilmeye çalışılmalı ve bu kapsamda çözümler geliştirilmelidir.
Partisipasi Masyarakat pada Penerapan Pembangunan Pariwisata Berkelanjutan (Studi Kasus Desa Wisata Pujon Kidul, Kabupaten Magelang)
Authors: Ira Widyarini Sistarukmi , Muhamad Muhamad
Published: April 2020

The development of sustainable tourism with tourism villages as its implementation has become one form of development that is considered in accordance with current needs, both from fulfilling economic needs as a parameter of the successful implementation of tourism development in the community and community involvement in tourism development in their area. This paper aims to record the form of implementation of the development of sustainable tourism in rural areas, with a focus on tourism villages seen from the impact of economic implications on income levels and shifts in people's livelihoods. Taking a case study in Pujon Kidul Tourism Village, Malang Regency. The research method was carried out by descriptive qualitative models and in-depth interviews. As a result, Pujon Kidul Tourism Village has succeeded in empowering the potential of its village through the development of sustainable tourism, as seen from the increased income of the community and the shift in the livelihood of agrarian communities to become entrepreneurs.
The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice
Authors: Rusliandi Rusliandi , Rousdy Diah Wulandari , Mukarlina Mukarlina
Published: April 2020

Humic acid is a humus compound found in peat soil. Humic acid can potentially be used as an anti-inflammatory compound. This study aimed to determine the effect of humic acid on the volume of foot mice edema and to find the best dose that can suppress the degree of edema volume. The animal object was Swiss mice weighing 25-30 grams and 3 months old. The study used Randomized Block Design (RBD) with positive control, negative control and humic acid treatment with dose 62.5 mg kg-1BW, 125 mg kg-1BW, and 250 mg kg-1BW. The result of this research showed that edema inhibition by the administration of humic acid dose 62,5; 125; 250 mg kg-1 had inflammatory inhibition percentage 2.67%, 13.34%, and 20.01% respectively in 5-hour observation. The best dose of humic acid to suppress inflammation in the mice's paw is a humic acid dose of 250 mg kg-1 compared with value 23.3% of sodium diclofenac as the positive control.
Optimization of Formula Granule of Lempuyang Gajah (Zingiber zerumbet (L) J.E.Smith) Rhizome Purified Extract as a Larvicide
Authors: Murini Tri , Wahyuningsih Mae Sri Hartati , Fudholi Achmad , Satoto Tri Baskoro Tunggul
Published: April 2020

Lempuyang gajah rhizome (Zingiber zerumbet (L) Smith is considered potential as larvicidal. A previous study has shown that the purified extract of Z. zerumbet rhizome was toxic against Adese aegypti larvae.  The aim of the study it to formulate a purified extract of Z. zerumbet (L) Smith in granule preparations by combining Sodium starch glycolate, PVP K-30 and tween 80.  The granule formulation was optimized by the Simplex Lattice Design (SLD) method with using Design expert program 7.1.5. The results showed that the interaction of the three components can increase the flow rate index, the angle of repose, and reduce absorption. The optimum formula obtained was Sodium starch glycolate 2%, PVP K-30 2%, and Tween 80 5%. The analysis of one sample t-test shows that there is no significant difference between the predicted parameter values and the experimental results of the flow rate index and angle of repose, while the absorption response is significantly different. The optimum formula for granules has larvicidal activity with 100% larval death during 12-hour treatment.
Potency of Sunkist Orange (Citrus sinensisL. Osbeck) against Kidney Histology of White Wistar Rats Induced by Gentamicin
Authors: Nasution Masdalena , Ginting Chrismis Novalinda , Fachrial Edy , Lister I Nyoman Ehrich
Published: April 2020

About 1.7%-58% of all cases of acute kidney failure are caused by gentamicin nephrotoxicity and consequently increasing urea and creatinine levels in the blood which are indications of damage to function. Oranges contain secondary metabolites such as flavonoids, alkaloids, coumarin, limonoid, keratinoid and essential oil that have pharmacological activities such as antioxidants, anti-inflammatory, anti-cancer, and also nephroprotector. The purpose of this study is to evaluate the nephroprotective activity of Citrus sinensis peel ethanol extract (EEKJS) on rats induced by gentamicin. Rats were induced using gentamicin at a dose of 80 mg/kgBW intraperitoneally on the 7th day after induced at a dose of 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW for 7 days. The results obtained from the ethanol extract of Citrus sinensis peel gave nephroprotective with the lowest serum creatinine and urea levels at a dose of 200 mg/kgBW which was 0.4±0.02 mg/dl and 43.33 ± 2.51 mg/dl and difference significantly (p<0.05) with a positive control group which was only induced by gentamicin and histopathological results showed significant cell damage in the positive control group that was only induced by gentamicin, and in the 50 mg/kgBW dose group, 100 mg/kgBW, 200 mg/kgBW had cell repair after gentamicin induction. Citrus sinensis are highly recommended to be a food supplement for kidney protection.
Research on the Application of Art Therapy into College Art Teaching in the Context of COVID-19 Prevention and Control
Authors: Yueqin Chen
Published: April 2020

Art therapy employ art symbols to externalize an individual’s psychology, emotion, personality and subconsciousness. Thus, it is widely applied in psychological consultation and treatment as well as clinical treatment of physical and mental diseases, whereas the study of integrating art therapy into art teaching among colleges and universities is rarely seen. To this end, this study, aimed at the psychological behavior and problems of college students who are prone to worry, dysphoria, fear, melancholy and irritability after the outbreak of COVID-19 in spring 2020, carries out the application research of integrating art therapy into college art teaching, in attempt to alleviate their psychological distress caused by the epidemic and assist them to establish a psychological defense mechanism for addressing future similar catastrophic events while inculcating art knowledge, and further develop the art teaching mode of “art therapy integrated into art teaching”.