bluuebunny/crossref_metadata_2025 huggingface dataset:
The master’s degree program “Intelligent management systems for enterprise digital ecosystem” as a modern innovative educational and production platform
Authors: Grigoriev S. G. , Smirnova G. S. , Sabitov R. A. , Korobkova E. A. , Elizarova N. Yu. , Sabitov Sh. R. , Eponeshnikov A. V.
Published: June 2024

The development of digitalization and the widespread intense implementation of digital ecosystems are an integral part of the successful economic development of enterprises and regions of the country as a whole. However, it should be noted that for the majority of the workforce, this process is accompanied by certain costs and difficulties. Modern technologies, such as artificial intelligence, robotics, and automation of processes, not only increase efficiency and productivity but also require new skills and competencies from the employees of enterprises.

In the context of digitalization, universities are faced with the task of training cross-functional specialists with knowledge in informatics, mathematics, and economics, who can meet the challenges of digital transformation of business and production. To solve such problems it is necessary to use not only new pedagogical technologies but also new training programs for future specialists. The program “Intelligent management systems for enterprise digital ecosystem” presented in the article for master’s degree training in 09.04.03 “Applied Informatics” is aimed at practice-oriented training in the conditions of Industry 4.0 and developing students’ interdisciplinary competencies in the field of IT solutions management, systems engineering, and economics. The program was developed taking into account labor market needs and active cooperation with manufacturing enterprises, which is reflected in its structure. In particular, the main part of the educational process under the program is focused on practice: project preparation and research work.
Using an online platform in a didactic learning model that stimulates critical thinking skills of future informatics teachers
Authors: Panjieva N. N.
Published: June 2024

Critical thinking is a key competency for future computer science teachers, who must be prepared not only for the rapid technological and informational development of the economy and society but also for the actively evolving process of digitalization in education. The aim of the research presented in the article is to develop methods and tools for enhancing critical thinking skills among future informatics teachers. To this end, the author has created an online platform that provides students with access to a variety of educational resources, including lectures, laboratory work, and interactive tasks. By integrating constructivist, cognitive, and sociocultural approaches to learning, this model promotes deep understanding and analysis of information by students. The platform is physically hosted on the server of Termez State University, built using the Python programming language with the Django framework, and is already being used by second-year students majoring in “Mathematics and Informatics”, studying under the discipline “Informatics and Digital Technologies”.

The online platform offers the necessary functionality for organizing independent study sessions and self-monitoring, allowing students to track their progress and develop the ability to critically evaluate information. The educational platform is a key component of the didactic model for developing critical thinking skills in future informatics teachers, the architecture of which is detailed in the article.

The results of the study presented in the article can be utilized in the educational practices of higher educational institutions (and even schools) seeking to update and optimize their training processes in the context of digitalization.
A repülőtéri forgalomban alkalmazható drónok típusspecifikációs kérdései
Authors: Simon Sándor , Vas Tímea , Dudás Zoltán
Published: June 2024

A pilóta nélküli légijármű-rendszerek (UAS) egyre szélesebb körben történő alkalmazása során felmerült a repülőtereken a repülőterek működését elősegítő úgynevezett munkadrónok alkalmazásának lehetősége is. E drónok elsősorban a repülőterek és azok környezete időjárásának előrejelzésére, a munkaterület vizsgálatára, a repülőtér védelemre, repülőtéren belüli szállítási feladatokra és más célokra lehetnek alkalmazhatók. A felsorolt feladatok elvégzéséhez a drónokat különböző szenzorokkal szerelik fel, amelyek lehetővé teszik légköri jellemzők (például hőmérséklet, légnyomás, páratartalom), képfelvételek, egyéb adatok összegyűjtését. Tekintettel arra, hogy technikai szempontból az UAS lehet távirányítású (RPAS) vagy teljesen autonóm rendszerű, repülésbiztonsági szempontból különböző kockázati szintekkel jellemezhető a repülőtéri környezetben. Cikkünkben a jelenleg érvényben lévő drónokra vonatkozó EU-s normák figyelembevételével, azokkal összhangban kívánjuk feltárni az ezen alkalmazásokra kínálkozó lehetőségeket.
A közelmúlt néhány fontos tanulsága a szállító légi járművek integrált repülőtéren történő kiszolgálásában és repülésre történő felkészítésében
Authors: Óvári Gyula , Varga Béla , Csató Péter
Published: June 2024

A Covid–19-világjárvány 2020-askitörése azonnali, jelentős kedvezőtlen hatást gyakorolt a légijármű-gyártásra, az ipari javításra, a repülőtéri és légi üzemeltetésre. Ez késlekedésmentes – rendszerint igen költséges – válaszlépésre kényszerítette valamennyi érintettet. Prognózisok szerint az elkövetkező években további pandémiák megjelenése is várható, ezért célszerű a most kidolgozott és bevált eljárások későbbi adaptálhatóságát áttekinteni.
A evolução do Direito Administrativo e seus desafios atuais
Authors: Teixeira Nunes Júnior Amandino
Published: June 2024

This paper intends to examine the evolution of Administrative Law, its main phases throughout history, from the beginnings to the present day, which reflect the political and economic transformations that society and the State have undergone. In fact, Administrative Law, as a legal discipline, is not timeless, insensitive to historical mutations; on the contrary, it is in permanent evolution, following the changes that constantly arise in different periods in the history of human civilization. The political-administrative organization of a given society will therefore dictate the essence of the Administrative Law in force in each historical period. In this context, relationships between the Public Administration and those administered are not static and vary over time. The aim is also to examine the current challenges facing Administrative Law in view of the need to adjust it to the new demands that arise with the changes taking place in society.
Implementations of The Digital Madrasah
Authors: Yamin Muh , Sanuri Dian
Published: June 2024

The demands of the times demand the world of education to be able to adapt and use technological developments in an effort to improve the quality of learning. The current development of information technology provides its own challenges in the world of education especially madrasah. Basically, the madrasah is an important Islamic educational institution in Indonesia, where its existence has proven to have marked a generation of nations with deep religious insights and the soul of nationalism. Therefore, the educational institutions of the Madrasah must be able to adapt to such massive technological developments. The madrasas must be capable of utilizing and integrating technology in teaching activities so that it becomes relevant and contextual with the development of the times. The aim of this research is to take stock of the efforts made by MTsN 1 Makassar in transforming into a digital madrasah, to find out the supporting factors and obstacles in implementing the digital madrasah policy. This type of research is qualitative descriptive. The results of the research describe the efforts made at MTsN 1 Makassar in transforming into a digital madrasah starting from the planning stage of both activity planning and budget planning, strengthening the quality of SDM by forming the learning revolution team 4. Supporting factors are the large number of digital flatforms that are open access, the support of the parents of the students and the factors that hinder are the price of relatively expensive digital devices, large electricity bills and a less stable internet network.
Decellularization and in vitro characterization of porcine small intestine scaffolds for complex wound treatments
Authors: Ruíz Soto Juan Pablo , Galvis Escobar Sara María , Rego Londoño Maria Antonia , Molina Sierra Juan David , Pineda Molina Catalina
Published: June 2024

Introduction: complicated skin injuries have become a global health problem, being difficult to treat due to the body’s limited healing process. Many studies aim to enhance traditional treatments for skin injuries, which have many disadvantages. Therefore, wound healing research is aiming towards tissue engineering options, such as decellularized matrix, which have shown great healing and biocompatibility competencies. Objectives:  to obtain and characterize the properties of a decellularized biological matrix derived from the small intestine of animals. Methods: porcine small intestine was prepared and decellularized using four different methods: Triton X-100, sodium dodecyl sulfate (SDS) and sodium deoxycholate (SDC) for one or two cycles of 6 hours or 24 hours, and peracetic acid for one cycle of 2 hours. The remaining DNA was quantified with Nanodrop and electrophoresis characterization. Histology stains and Scanning Electron Microscopy (SEM) were performed to assess surface structure and integrity. Resistance assays were conducted to measure mechanical strength. Finally, degradability assays with different buffers were performed. Results: no differences between the decellularization protocols regarding remaining DNA were found, making protocols of one cycle of six hours more efficient. With the least remaining DNA content and better structure perseveration, TX-100 could be considered as the best protocol. No statistically difference between protocols and native tissue were found during the mechanical analysis. Biodegradability assays showed the expected degradability properties of the produced matrix. Conclusions: promising results were achieved to obtain decellularized biological matrices that could serve as a treatment for complicated skin wounds. More in vitro and molecular studies should be carried out in future studies to further characterize these scaffolds.
Kebersihan Tangan, Kuku, dan Infeksi Soil-Transmitted Helminths pada Siswa
Authors: Ryzka Puput Yunisyar  , Satriani Hadi  , Zulfitriani Murfat  , Hermiaty Nasaruddin  , Dahlia
Published: June 2024

Prevalensi cacingan di Indonesia masih sangat tinggi, terutama pada golongan penduduk yang kurang mampu. Orang-orang yang berisiko tinggi mengalami infeksi kecacingan adalah anak pra sekolah, anak usia sekolah, wanita usia subur, orang dewasa dalam pekerjaan berisiko tinggi seperti pertanian atau pertambangan. Penularan kecacingan dapat terjadi secara langsung melalui tangan yang kotor, kuku panjang, dan tanah yang menyelubungi telur cacing yang tersebar, serta ditambah kurangnya perilaku mencuci tangan dengan sabun sebelum makan. Selain itu, ada pula faktor perilaku yang meliputi kebiasaan tidak memakai alas kaki baik di rumah maupun saat bermain serta kebiasaan bermain di tanah, yang juga merupakan faktor yang berpengaruh terhadap terjadinya kecacingan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan kebersihan tangan dan kuku terhadap infeksi Soil-Transmitted Helminths pada siswa UPT SD Negeri 101 Salu Simbuang, Kelurahan Walenrang Barat, Kabupaten Luwu. Jenis penelitian ini adalah observasional dengan menggunakan rancangan cross-sectional, yaitu dengan cara pengumpulan data sekaligus pada suatu waktu dengan tujuan untuk mencari pengaruh antara variabel independen terhadap variabel dependen. Dalam kelompok yang menjaga kebersihan tangan dan kuku (kategori "Buruk"), terdapat 4 orang (7,3%) yang negatif terinfeksi Soil-Transmitted Helminths dan 2 orang (3,6%) yang positif terinfeksi STH dari total 6 orang responden. Sedangkan pada kelompok yang menjaga kebersihan tangan dan kuku (kategori "Baik"), terdapat 49 orang (89,1%) yang negatif terinfeksi STH dan tidak terdapat orang (0,0%) yang terinfeksi STH dari total 49 orang responden. Terdapat hubungan yang signifikan antara Kebersihan Tangan dan Kuku dengan Infeksi STH.
Investigation of the Holy Crown as a Metal Structure
Authors: Barabássy Miklós
Published: June 2024

The article analyses the crown of Hungarian kings, a crown of sacral importance, as an engineered metal structure resulting from a technological process. Its composition revolves around two primary components: the cross-strap and the hoop. The cross-strap consists of the actual cross-strap stems and the cross. As for the hoop crown, it comprises the hoop, the diadem (a pediment), and the pendants. The assembly sequence of these parts and sub-parts are described, how the hoop and the cross-strap were aligned and how the sub-parts—the diadem, pendants, and various decorative elements—were assembled and aligned with the primary components. A 3D fully parametric CAD model was used for the analysis. Results show that the eightfold division of the hoop is accurate and that the cross-straps are made with a small degree of inaccuracy, suggesting that they were developed independently. Alignment of the hoop was achieved by asymmetrical cutting, to align with the centerline of the back cross strap stem. The diadem, pendants, and other decorative elements, although fixed to the hoop in a coherent manner, are aligned with the cross-strap. Consequently, the cross-strap emerges as the defining element of the unified Holy Crown, around which all other components are harmoniously aligned.
Soğuk Savaş Sonrası İran-Rusya İlişkileri: Teşvik Edici Ve Sınırlandırıcı Faktörler
Authors: Çetin İbrahim , Akçapa Mevlüt
Published: June 2024

Bu araştırmanın konusu, soğuk savaşın bitiminden sonra inişli çıkışlı bir seyir izleyen İran Rusya ilişkilerinin İran devriminden sonraki söylemle “küçük şeytan’’ kavramından, Suriye ve Ukrayna savaşlarında ifade edilen “stratejik ortak’’ söylemine nasıl ve neden evrildiğini incelemektir. Ayrıca, İran-Rusya ilişkilerini teşvik eden ve sınırlayan faktörler ortaya konmaya çalışılacaktır. Araştırma, veri toplamak için literatür taraması yöntemini kullanırken, analiz için nitel araştırma yöntemlerinden vaka analizinin bir alt kolu olan süreç analizi kullanılmıştır. Neorealizm bakış açısıyla olayların incelenmesi, olayların devlet, sistem, güç ve güç dengesi yönlerinden analizini kolaylaştırmıştır. Araştırmanın sonucunda, İran ile Rusya’yı yakınlaştıran temel nedenin ABD ve müttefiklerinden oluşan blokun etkisini Ortadoğu ve Kafkasya’da siyasi ve askeri yönden dengelemek olduğu; ambargoların bu yakınlaşmayı hızlandırdığı kanaatine varılmıştır. Rusya’nın BMGK’deki veto hakkı, nükleer enerji alanındaki işbirlikleri ve silah ticaretleri de ilişkilerin önünü açan nedenler olarak tespit edilmiştir. İki ülke arasındaki ilişkileri sınırlayan nedenler ise; her iki ülkenin ABD ve müttefikleri ile olan ilişkileri, ticari faaliyetlerin sadece nükleer teknoloji ve silah ticareti ile sınırlı olması olarak belirlenmiştir. Ayrıca, halklar arasındaki etkileşimin azlığının da ortaklığın derinleşmesini sınırlayan önemli bir faktör olduğu değerlendirilmiştir.Araştırmanın sonucunda, İran ile Rusya’yı yakınlaştıran temel nedenin ABD ve müttefiklerinden oluşan blokun etkisini Ortadoğu ve Kafkasya’da siyasi ve askeri yönden dengelemek olduğu; ambargoların bu yakınlaşmayı hızlandırdığı kanaatine varılmıştır. Rusya’nın BMGK’deki veto hakkı, nükleer enerji alanındaki işbirlikleri ve silah ticaretleri de ilişkilerin önünü açan nedenler olarak tespit edilmiştir. İki ülke arasındaki ilişkileri sınırlayan nedenler ise; her iki ülkenin ABD ve müttefikleri ile olan ilişkileri, ticari faaliyetlerin sadece nükleer teknoloji ve silah ticareti ile sınırlı olması olarak belirlenmiştir. Ayrıca, halklar arasındaki etkileşimin azlığının da ortaklığın derinleşmesini sınırlayan önemli bir faktör olduğu değerlendirilmiştir.
Fuzzy-Logic Based Model for VANET Performance Metrics Analysis
Authors: Baloch Shahnila Badar , Muhammad Tayyab Yaqoob  , Asif Gulraiz  , Rabbia Muhammad Qasmi
Published: June 2024

Vehicular Ad-hoc Networks (VANETs) allows a spontaneous communication between vehicle to vehicles and road-side units(RSU) using wireless interfaces and road-side infrastructure to form Intelligent Transportation System (ITS). VANET, prime objective is to provide information about accidents or unwanted situations and traffic conditions to the drivers. As VANETs are dynamic in nature, the vehicle nodes to discover the best possible route to broadcast an emergency message is a challenge. To study different highway and urban road scenarios, there is a need to simulate and evaluate the network performance analysis of routing protocols beforehand since real-time implementation is rather challenging or expensive. This paper focuses on the VANET routing protocols evaluation, to find an appropriate protocol which provide suitable Quality of Service (QoS) to end users in both safety and non-safety conditions. To simplify the QoS evaluation problem, Hierarchical Fuzzy Inference System (HFIS) model has been designed and simulated in MATLAB R2018b that analysis the network performance metrics of VANET routing protocols. From the simulations, it is observed that that OLSR routing protocol for both safety and non-safety applications, outperforms other routing protocols as its global QoS reaches to approximately 84% efficiency.
Las expresiones culturales vinculadas a la cultura sorda y la lengua de signos española como manifestación representativa del patrimonio cultural inmaterial
Authors: Esteban Saiz María Luz
Published: June 2024

El Consejo de Ministras/os aprobó el 6 de febrero de 2024 la declaración de las expresiones culturales vinculadas a la cultura sorda y la lengua de signos española como manifestación representativa del patrimonio cultural inmaterial. Esta iniciativa reconoce la cultura sorda que comprende valores, conocimientos, tradiciones y formas de socialización compartidas por la comunidad sorda. Asimismo, reconoce las expresiones culturales que emanan de la lengua de signos española, las expresiones artísticas en Visual Vernacular, y destaca el papel fundamental de las asociaciones de personas sordas como el principal espacio de salvaguarda de la cultura sorda. La relevancia de esta declaración se fundamenta en la singularidad de la lengua de signos española, su situación de vulnerabilidad y la necesidad de protección de las expresiones culturales asociadas. Estas manifestaciones, surgidas de una lengua minoritaria y minorizada, se enfrentan a diversos riesgos y amenazas. Por tanto, este reconocimiento normativo representa un avance significativo para la proyección y promoción de la cultura sorda y la lengua de signos española en el marco de los derechos culturales de las minorías.
Sosialisasi Petugas Rekam Medis Terhadap Penggunaan Sistem Informasi Registrasi Di Puskesmas Tumbuan
Authors: Arifin Ismail , Heltiani Nofri , ANANDA HARAHAP VICKY , AFRILIA UTARI LEZZA
Published: June 2024

Sistem informasi merupakan gabungan dari manusia, fasilitas, teknologi yang bertujuan untuk memperoleh jalur komunikasi yang penting baik untuk kebutuhan internal maupun eksternal. Puskesmas Tumbuan merupakan salah satu fasilitas kesehatan yang baru-baru ini menerapkan sistem informasi pendaftaran bagi pasiennya. Sistem informasi puskesmas (simpus) yang ada baru dibuat dan belum diimplementasikan untuk petugas yang ada. Dalam kegiatan pengabdian ini akan dilakukan sosialisasi pemahaman kepada petugas rekam medis tentang penggunaan sistem informasi registrasi. Hal itu dilakukan karena sebelumnya di Puskesmas Tumbuan masih melakukan pendaftaran secara manual, guna meminimalisir kesalahan dalam penggunaan sistem. Kemudian akan diberikan sosialisasi kepada 4 petugas rekam medis terkait penggunaan sistem baru tersebut. Metode yang digunakan dalam hal ini adalah dengan memberikan pre dan post test kepada petugas rekam medis. dengan memberikan pre and post test dapat mengetahui pemahaman petugas sebelum dan sesudah diberikan sosialisasi. Diketahui setelah diberikan sosialisasi petugas paham dan mengerti cara penggunaan sistem informasi pendaftaran pasien. Petugas mudah melakukan pendaftaran, pencetakan Laporan hanya <10 menit, Petugas puas dengan sistem pendaftaran pasien di Puskesmas Tumbuan
Pelatihan penggunaan aplikasi e-konsuling AUM PTSDL bagi guru dan siswa SMA 2 Kota Bengkulu
Authors: Aan Erlansari
Published: June 2024

Pengelolaan data analisa masalah belajar siswa secara manual yang dilaksanakan oleh Guru Bimbingan dan Konseling menggunakan instrumen Alat Ungkap Masalah Belajar (PTSDL) Siswa memungkinkan pengerjaanya memakan waktu yang tidak sedikit. Hal ini disebabkan oleh jumlah data siswa yang tidak sedikit dan perhitungan bobot setiap jawbaan siswa pada lembar jawaban Alat Ungkap Masalah Belajar (PTSDL) Siswa. Pemanfaatan teknologi informasi sebagai sarana untuk memudahkan para guru dan siswa untuk dapat menyelesaikan permasalahan yang konvensional tersebut. Literasi e-konsuling Aum-ptsdl dengan aplikasi digital berbasis web disampaikan dengan metode pemaparan dan pelatihan untuk mencapai kesempurnaan dalam pemahaman para guru dan siswa. Tujuan akhir dalam pengabdian ini adalah untuk membantu para guru dalam mengatasi permasalahan siswa dan dapat mencari solusi dari permasalahan mereka dengan metode Aum-Ptsdl.
Leveraging Marker-based Augmented Reality to Enhance Simplified Representation Learning in Mechanical Drawing : A Practical Studies in The Mechanical Engineering Curriculum
Authors: Wardhani Rivai
Published: June 2024

This study aims to develop AR technology of simplified representations based on ISO standards and to quantify the efficiency and contribution of developed AR technology in assisting students in learning mechanical drawing. This research proposed a marker-based AR application development, intended for teaching simplified representations, named Augmented Reality Penyederhanaan Gambar - ARPeGa, and an experimental study to quantify the user experience (UX) using the User Experience Questionnaire (UEQ). A pilot study involving 38 mechanical engineering students was conducted to evaluate the impact of AR involvement on user experience. In addition, the UEQ data analysis tool version 11 was used.  The UEQ results showed attractiveness was excellent (1.87), while efficiency, dependability, stimulation, and novelty were good (1.63, 1.60, 1.63, and 1.22 respectively). And perspicuity was categorized as “above average” (1.51). This study’s outcomes demonstrate that using 3D model visualization in the AR application strengthens user experiences to understand simplified representations. Overall, the application has a ‘good’ level in some categories: efficiency, dependability, stimulation, and novelty.
How Does Creativity and Environmental Support Matter on University Students’ Digital Entrepreneurial Intention? : A Mediated Model
Authors: Indira Fransisca Rahcmawati , Wardani Dewi Kusuma , Murwaningsih Tri
Published: June 2024

This study aims to investigate the effects of self-perceived creativity and environmental support on university students' digital entrepreneurial intentions while also examining a mediation model. This research used a survey method with a quantitative approach. The data was collected involving undergraduate students in Economic Education from three universities in Central Java province. The study engaged 531 population and 229 samples selected using the proportionate random sampling method. SEM-PLS analysis was employed for data analysis. The findings suggest that digital entrepreneurial intention is positively, albeit not significantly, impacted by self-perceived creativity. Meanwhile, digital entrepreneurial intention is positively and significantly impacted by both environmental support and digital entrepreneurial self-efficacy. Moreover, digital entrepreneurial self-efficacy is also positively and significantly impacted by self-perceived creativity and environmental support. Then, the mediation models are also accepted. The results suggest fostering creativity-based learning programs, training, internships, and short courses to enhance students' confidence in digital entrepreneurship and entrepreneurial intentions. To this end, collaborating with universities, governments, and private sectors is crucial in executing such initiatives.
Development of Competitive Strategies in the "Clarinet" (Clustering and Networking) Model in Private Schools to Increase Student Interest
Authors: Hapsari Penta Karuni , Listyani Listyani , Ismanto Bambang
Published: June 2024

This research aims to describe the framework for developing competitive strategies for schools using “Clarinet” (clustering and networking) models, as well as to assess the feasibility of the development guide for competitive strategies in “Clarinet” models. This research uses a qualitative approach with the Research and Development (R&D) method by Borg and Gall. Data collection is conducted through questionnaires, documentation studies, in-depth interviews, and Focus Group Discussions (FGD). Data collection is done through documentation studies, interviews, questionnaires, and focus group discussions. The data analysis is conducted through the triangulation of techniques and sources. The results show that the validation test for the feasibility of the model and competitive strategies by education management experts yielded 88%, and marketing management experts yielded 96%. The research results indicate that the trial of the competitive strategy product using clustering and networking models is approximately 94% (very good/very valid). It is concluded that the competitive strategy within clustering and networking models is worthy of implementation to enhance the interest of students.
Cyberloafing and Job Burnout Among Educators : How Does Organizational Commitment Play A Role as A Moderating Variable?
Authors: Ali Muhammad Yusuf , Mulyati Heti , Sukmawati Anggraini
Published: June 2024

This study aims to analyze the effects of job burnout and cyberloafing on educator performance and the role of job burnout on cyberloafing, moderated by organizational commitment. This research employs a quantitative approach to validate hypotheses involving educators from the State University with Legal Entity Status in West Java, using a sample of 377 respondents and a questionnaire instrument adapted from various previous studies. Data was collected through questionnaires and analyzed using the Partial Least Square Equation Modeling (PLS-SEM) technique with SmartPLS software. The results indicate that job burnout has a significant positive effect on cyberloafing, suggesting that higher levels of job burnout correspond to an increased tendency for cyberloafing. Meanwhile, organizational commitment is an effective moderator in reducing the negative impact of job burnout on cyberloafing, which in turn helps improve employee performance. Thus, the study demonstrates that job burnout increases cyberloafing behaviour and decreases employee performance, yet organizational commitment can act as an effective moderator to mitigate these negative impacts. The implications of this research suggest that educational organizations can reduce the negative impact of burnout and cyberloafing on educator performance by promoting organizational commitment. This can contribute to creating a healthier and more productive work environment.
Exploring Dickens’ Stylistics : Pedagogical Strategies for Enhancing Literature Teaching and Learning
Authors: Fahri Fahri , Zuhri Fauris , Subandiyah Heny , Abida Fithriyah Inda Nur , Sumarniningsih Sumarniningsih
Published: June 2024

This study explores the impact of incorporating the stylistic method and diverse pedagogical approaches on students' understanding and appreciation of literary works, specifically focusing on the works of Charles Dickens. This research used a mixed-methods approach, combining qualitative methods such as observation, surveys, and text analysis with quantitative methods involving statistical analysis. The quasi-experimental design selected undergraduate students purposively based on their literary background, with Charles Dickens' notable works serving as key resources. Pre and post-tests are administered to experimental and control groups to measure the impact of language style instruction. Results indicate that the experimental group, exposed to language style teaching, outperforms the control group in post-teaching comprehension tests. Studies show that teaching students about language styles helps them unlock the meaning of literature. Questionnaire data demonstrate high student satisfaction, increased confidence, improved critical thinking, and enhanced analytical abilities. The adaptability of Dickens's novels to various learning styles contributes to a more inclusive learning environment.
Stunting in Indonesia: Current progress and future directions
Authors: Lameky Vernando Yanry
Published: June 2024

This narrative review article aims to describe the issue of stunting in Indonesia, a condition from chronic malnutrition that impairs children’s growth and development. With a stunting prevalence of approximately 30% among children under five, this problem is a critical concern for policymakers and healthcare providers. The article also reviews various interventions, including programs to enhance nutrition, promote breastfeeding, and improve sanitation. By assessing these existing interventions, health policy strategies and service management enhancements are proposed to reduce stunting rates. It underlines the necessity of a comprehensive approach integrating cross-sector collaboration and community engagement to achieve lasting solutions. The insights provided are crucial for policymakers to refine and enhance intervention strategies, aiming to lessen the long-term health impacts and improve children’s well-being in Indonesia.
Proposal of Invader Pontederia crassipes as a Savior of Micro and Macro Size Plastic Pollution
Authors: Kılıç Ece , Yücel Nebil
Published: June 2024

This study is the first report evaluating the microplastic (MP) and macroplastics capture potential of Pontederia crassipes. Total of 3691 (508 microplastic and 3183 macroplastic) particles were extracted from the roots of 12 examined specimens. Mean macroplastic abundance in the roots was found as 265±44 macroplastic/specimen. Majority of the extracted macroplastics were fragment in shape, blue in color. Mean microplastic abundance was found as 42±23 MPs/specimen. Majority of the extracted microplastics were fragment in shape, blue in color and less than 500 μm in size. Results of this preliminary study showed that this species have significant ability to adsorb micro and macroplastics by the roots which makes them perfect employees for integrated floating systems.
Effect of Skin Antiseptics Used in Peripheral Intravenous Catheter Application on Phlebitis Development: A Double- Blind Randomized Controlled Trial
Authors: Keskin Alev , Eskimez Zehra
Published: June 2024

Objective: This study aimed to examine the effect of antiseptics used in peripheral intravenous catheter (PIVC) application on phlebitis development.
Methods: This is a double-blind randomized controlled trial that is suitable for the Consolidated Standards of Reporting Trials (CONSORT) statement. The study was carried out at a University Hospital in Turkey. The study participants were 60 patients (experiments 30 and control 30). 2% chlorhexidine was used as a skin antiseptic in the intervention group and 70% alcohol was used in the control group. In both groups, the catheter insertion site was observed every 8 hours for 72 hour. Data were obtained using the “Personal Information Form” and “Phlebit Scale”. Independent samples t-test (t-table value), Mann–Whitney U test (Z-table value) and Fisher’s exact test, continuity correction, or Pearson’s χ2 cross tables were used for data analysis.
Results: No statistically significant difference was found between 2% chlorhexidine and 70% alcohol in preventing the development of phlebitis after PIVC application (p > 0.05).
No statistically significant relationship was found between the intervention and control groups in terms of sex, BMI, substance abuse, alcohol use, smoking, chronic disease, or PIVC application area (p>0.05). The highest degree of phlebitis that developed in the intervention and control groups was 1st degree. There was also no statistically significant difference between the groups in terms of degree of phlebitis and phlebitis development time (p > 0.05).
Conclusions: In line with the findings obtained from this study, it is thought that both skin antiseptics used when inserting a peripheral intravenous catheter are effective in preventing the development of phlebitis and will guide healthcare personnel in the selection of antiseptics.
Attenuated mutants of Salmonella enterica Typhimurium mediate melanoma regression via an immune response
Authors: Pérez Jorge Genesy , Gontijo Marco , Silva Marina Flóro e , Goes Isabella Carolina Rodrigues Dos Santos , Jaimes-Florez Yessica Paola , Coser Lilian de Oliveira , Rocha Francisca Janaína Soares , Giorgio Selma , Brocchi Marcelo
Published: June 2024

The lack of effective treatment options for an increasing number of cancer cases highlights the need for new anticancer therapeutic strategies. Immunotherapy mediated by Salmonella enterica Typhimurium is a promising anticancer treatment. Candidate strains for anticancer therapy must be attenuated while retaining their antitumor activity. Here, we investigated the attenuation and antitumor efficacy of two S. enterica Typhimurium mutants, ΔtolRA and ΔihfABpmi, in a murine melanoma model. Results showed high attenuation of ΔtolRA in the Galleria mellonella model, and invasion and survival in tumor cells. However, it showed weak antitumor effects in vitro and in vivo. Contrastingly, lower attenuation of the attenuated ΔihfABpmi strain resulted in regression of tumor mass in all mice, approximately 6 days after the first treatment. The therapeutic response induced by ΔihfABpmi was accompanied with macrophage accumulation of antitumor phenotype (M1) and significant increase in the mRNAs of proinflammatory mediators (TNF-α, IL-6, and iNOS) and an apoptosis inducer (Bax). Our findings indicate that the attenuated ΔihfABpmi exerts its antitumor activity by inducing macrophage infiltration or reprogramming the immunosuppressed tumor microenvironment to an activated state, suggesting that attenuated S. enterica Typhimurium strains based on nucleoid-associated protein genes deletion could be immunotherapeutic against cancer.
Cortico-cancellous osseointegration into additively manufactured titanium implants using a load-bearing femoral ovine model
Authors: Feldman Adam , Assad Michel , Davies Mark B. , Mangwani Jitendra , Alabort Enrique , Tuncer Mac
Published: June 2024

Introduction: Titanium-based implants can be used to fill voids in bone reconstruction surgery. Through additive manufacturing (AM), it is possible to produce titanium implants with osteoconductive properties such as high porosity and low stiffness. AM facilitates a level of design flexibility and personalization that is not feasible with traditional techniques.

Methods: In this study, osseointegration into titanium alloy (Ti-6Al-4V) lattices was investigated for 12 weeks post-implantation using a novel bicortical load-bearing ovine model. The objective was to assess the safety and efficacy of AM-fabricated implants using two lattice structures of contrasting stiffness spanning the full width of the femoral condyle.

Results: This was achieved by evaluating implant osseointegration and bone–implant contact properties by histomorphometry, scoring local implant tissue responses via histopathology, and micro-computed tomography reconstruction.

Discussion: We found that Ti-6Al-4V implants facilitated widespread and extensive osseointegration, with bone maturation ongoing at the conclusion of the trial period. Following the implantation period, no adverse clinical indications that could be directly ascribed to the presence of the implanted device were identified, as determined by macroscopic and microscopic observation.
AnXplore: a comprehensive fluid-structure interaction study of 101 intracranial aneurysms
Authors: Goetz Aurèle , Jeken-Rico Pablo , Pelissier Ugo , Chau Yves , Sédat Jacques , Hachem Elie
Published: June 2024

Advances in computational fluid dynamics continuously extend the comprehension of aneurysm growth and rupture, intending to assist physicians in devising effective treatment strategies. While most studies have first modelled intracranial aneurysm walls as fully rigid with a focus on understanding blood flow characteristics, some researchers further introduced Fluid-Structure Interaction (FSI) and reported notable haemodynamic alterations for a few aneurysm cases when considering wall compliance. In this work, we explore further this research direction by studying 101 intracranial sidewall aneurysms, emphasizing the differences between rigid and deformable-wall simulations. The proposed dataset along with simulation parameters are shared for the sake of reproducibility. A wide range of haemodynamic patterns has been statistically analyzed with a particular focus on the impact of the wall modelling choice. Notable deviations in flow characteristics and commonly employed risk indicators are reported, particularly with near-dome blood recirculations being significantly impacted by the pulsating dynamics of the walls. This leads to substantial fluctuations in the sac-averaged oscillatory shear index, ranging from −36% to +674% of the standard rigid-wall value. Going a step further, haemodynamics obtained when simulating a flow-diverter stent modelled in conjunction with FSI are showcased for the first time, revealing a 73% increase in systolic sac-average velocity for the compliant-wall setting compared to its rigid counterpart. This last finding demonstrates the decisive impact that FSI modelling can have in predicting treatment outcomes.
Cur@ZIF-8@BA nanomaterials with pH-responsive and photodynamic therapy properties promotes antimicrobial activity
Authors: Shang Xiujuan , Wang Hongdong , Yu Yongbo , Gu Jin , Zeng Jian , Hou Sinan
Published: June 2024

Antimicrobial photodynamic therapy (aPDT) has emerged as a highly promising strategy for non-antibiotic treatment of infections due to its unique advantages in efficient bactericidal action and reduction of drug resistance. The natural photosensitizing properties of curcumin (Cur) are widely acknowledged; however, its limited bioavailability has impeded its practical application. In this study, we developed a nanomaterial called Cur@ZIF-8@BA by encapsulating Cur within ZIF-8 and modifying the surface with boric acid (BA). The Cur@ZIF-8@BA exhibits pH-responsive properties and enhances bacterial binding, thereby effectively promoting photodynamic therapy. Moreover, its antibacterial activity against E. coli, Staphylococcus aureus and A. baumannii is significantly increased in the presence of light compared to a dark environment. The mechanism behind this may be that BA increases the affinity of Cur@ZIF-8@BA towards bacteria, and making released Zn2+ and BA from the nanomaterial increase bacterial cell membrane permeability. This facilitates efficient delivery of Cur into bacterial cells, resulting in generation of abundant reactive oxygen species (ROS) and subsequent bactericidal activity. In conclusion, our prepared Cur@ZIF-8@BA holds great promise as a photodynamically mediated antimicrobial strategy.
Reducing neuroendocrine psychosocial stress response through socio-emotional dyadic but not mindfulness online training
Authors: Matthaeus Hannah , Heim Christine , Voelkle Manuel C. , Singer Tania
Published: June 2024

Introduction

Stress-related diseases pose significant health risks and show wide prevalence. Empirical evidence suggests that contemplative practices, such as socio-emotional dyadic mental exercises, hold promise in mitigating the adverse effects of stress and promoting psychosocial well-being. This study aimed to investigate the differential effects of two online contemplative mental training programs on the psychosocial stress response: the first involved classic mindfulness practices, while the second incorporated a socio-emotional dyadic approach known as Affect Dyad.

Methods

The study was conducted as part of the longitudinal CovSocial project’s phase 2 in the context of the COVID-19 pandemic. 140 individuals participated in the Trier Social Stress Task (TSST), where the psychosocial stress response was assessed with cortisol saliva samples and subjective stress questionnaires in a cross-sectional design after the active training groups finished their intervention period. Participants were randomly assigned to the socio-emotional training group, mindfulness-based training group, or a control group that did not receive any training. Both training programs consisted of a ten-week intervention period with a daily 12-minute app-based mental training practice and weekly 2-hour online coaching sessions led by mental training teachers.

Results

Results showed that the socio-emotional Dyad group but not the mindfulness-based group exhibited significantly lower cortisol levels at 10, 20, 30, and 40 minutes after the stressor as well as lower total cortisol output compared to the control group during the TSST, indicating a reduced hormonal stress response to a social stressor. Subjective markers did not show differences between the three groups.

Discussion

These findings indicate that the daily socio-emotional dyadic practice, which emphasizes non-judgmental and empathic listening as well as the acceptance of challenging emotions in the presence of others within one's daily life context, may serve as a protective factor against the adverse effects of psychosocial stress triggered by the fear of negative social judgments. Given the high prevalence of stress-related diseases, such online mental training programs based on dyadic practices may thus represent an efficient and scalable approach for stress reduction.
The interference of anti-TSH autoantibody on clinical TSH detection
Authors: Tang Mulin , Meng Xue , Ni Jiajia , Liu Xue , Wang Xinhui , Li Yuchen , Chai Yuwei , Kou Chunjia , Zhang Li , Zhang Haiqing
Published: June 2024

Objective

It is well known that macro-thyroid-stimulating hormone (macro-TSH) could interfere with the detection of TSH. The anti-TSH autoantibody is an essential component of macro-TSH. However, the epidemiological characteristics and the clinical interference of the anti-TSH autoantibody are unclear.

Methods

In this study, the radioimmunoprecipitation technique was used to detect the anti-TSH autoantibody. Platforms with different detection mechanisms were applied to measure the TSH in patients with the anti-TSH autoantibody. Polyethylene glycol (PEG) precipitation was used to determine the immunoassay interference.

Results

The prevalence of the anti-TSH autoantibody in patients with mild subclinical hypothyroidism (SCH) and autoimmune thyroiditis, but normal thyroid function, was 4.78%. All 10 patients with anti-TSH antibodies had autoimmune diseases, with five of them having significant clinical test interference.

Conclusion

The appearance of the anti-TSH antibody is not associated with thyroid autoantibodies. The presence of the anti-TSH autoantibody can interfere with the detection of TSH and can affect clinical diagnosis and treatment.
Advances in the interaction between lumbar intervertebral disc degeneration and fat infiltration of paraspinal muscles: critical summarization, classification, and perspectives
Authors: Jiang Jiaqiu , Huang Yilong , He Bo
Published: June 2024

More than 619 million people in the world suffer from low back pain (LBP). As two potential inducers of LBP, intervertebral disc degeneration (IVDD) and fat infiltration of paraspinal muscles (PSMs) have attracted extensive attention in recent years. So far, only one review has been presented to summarize their relationship and relevant mechanisms. Nevertheless, it has several noticeable drawbacks, such as incomplete categorization and discussion, lack of practical proposals, etc. Consequently, this paper aims to systematically summarize and classify the interaction between IVDD and fat infiltration of PSMs, thus providing a one-stop search handbook for future studies. As a result, four mechanisms of IVDD leading to fat infiltration of PSMs and three mechanisms of fat infiltration in PSMs causing IVDD are thoroughly analyzed and summarized. The typical reseaches are tabulated and evaluated from four aspects, i.e., methods, conclusions, benefits, and drawbacks. We find that IVDD and fat infiltration of PSMs is a vicious cycle that can promote the occurrence and development of each other, ultimately leading to LBP and disability. Finally, eight perspectives are proposed for future in-depth research.
Projecting the response of carbon sink potential to land use/land cover change in ecologically fragile regions
Authors: Wang Ye , Liu Jie , Zhang Lirong , Xue Zhongcai , Yang Yue
Published: June 2024

Introduction: The carbon storage service of ecosystems in ecologically fragile areas is highly sensitive to regional land use/land cover (LULC) changes. Predicting changes in regional carbon storage under different LULC scenarios is crucial for land use management decisions and exploring carbon sink potential. This study focuses on the Luan River Basin, a typical ecologically fragile area, to analyze the impact of LULC changes on carbon storage.

Methods: The PLUS-InVEST model was employed to simulate LULC patterns for the year 2030 under three scenarios: natural development, cropland protection and urban development, and ecological protection. The model projected the future carbon sink potential of the basin under these scenarios.

Results: From 2000 to 2020, carbon storage showed a trend of decrease followed by an increase. By 2030, compared to 2020, carbon storage is projected to increase by 16.97% under the ecological protection scenario and decrease by 22.14% under the cropland protection and urban development scenario. The increase in carbon storage was primarily due to the conversion of cropland and grassland to forestland, while the decrease was mainly associated with the conversion of forestland to grassland and cropland, and the transformation of grassland to cropland and construction land. In the potential LULC scenarios of 2030, certain regions within the basin exhibited unstable carbon sink potential, strongly influenced by LULC changes. These areas were predominantly characterized by artificially cultivated forests, shrubs, and agricultural land. Implementing appropriate forest management measures and optimizing agricultural land management practices are essential to enhance carbon sink potential in these regions. Population density, annual average temperature, and DEM (Digital Elevation Model) were the dominant factors driving the spatial variation of carbon sink potential in the Luan River Basin.

Discussion: The research results provide a theoretical basis for rational planning of land use and the enhancement of carbon sink potential in ecologically fragile regions.