bluuebunny/crossref_metadata_2025 huggingface dataset:
Two new species of the genus Metaxonchium Coomans & Nair, 1975 (Nematoda, Dorylaimida, Belondiridae) from Vietnam
Authors: NGUYEN THI ANH DUONG , PEÑA-SANTIAGO REYES
Published: April 2018

Two new species of the genus Metaxonchium are described from natural habitats of Vietnam. Metaxonchium bonkowskii sp. n. is characterized by its 1.69–2.23 mm long body, lip region offset by weak constriction and 9.5–10.5 µm broad, odontostyle 11–13 µm long, neck 673–868 µm long with the pharyngeal expansion occupying 66–77% of its length, anterior genital branch reduced to a uterine sac 75–135 µm long or 4–7% of body length, posterior uterus tetrapartite and including a Z–like differentiation, V = 51–55, and female tail short and rounded (37–51 µm, c = 66–97, c’ = 0.5–0.7). Metaxonchium silvaticum sp. n is characterized by its 1.28–1.43 mm long body, lip region offset by weak depression and 7.0 µm broad, odontostyle 8–9 µm long, neck 502–630 µm long with the pharyngeal expansion occupying 65–76% of its length, anterior genital branch reduced to a uterine sac 65–80 µm long or 4–6% of body length, posterior uterus tripartite, non-echinophor, V = 52–57, tail short and rounded (18–23 µm, c = 56–74, c’ = 0.6–0.8) with abundant blister–like or saccate bodies, spicules 41 µm long, and seven spaced ventromedian supplements.
Oligotomidae (Insecta: Embioptera) of Mt. Makiling, Los Baños, Philippines, with description of a new species
Authors: LUCAÑAS CRISTIAN C. , LIT IRENEO L. JR.
Published: April 2018

The diversity of webspinners (Insecta: Embioptera) in Mt. Makiling, Los Baños was studied. Four species were recorded: Aposthonia borneensis (Hagen), A. merdelynae Lucañas & Lit n. sp., Oligotoma humbertiana (Saussure) and O. saundersii (Westwood). Each was illustrated and described. The new species differs from its congeners by relatively smaller size, subcylindrical left basal cercus with an inner lobe, and enlarged membranous area of the 10RP. A dichotomous key was devised to aid in identification of each species.
CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML
Authors: Lucas Claire M. , Scott Laura J. , Carmell Natasha , Holcroft Alison K. , Hills Robert K. , Burnett Alan K. , Clark Richard E.
Published: April 2018

Key Points

PP2A inhibition occurs in AML by 2 different pathways: CIP2A in normal karyotype patients and SETBP1 in adverse karyotype patients. AKTS473 phosphorylation is a predictor of survival, and diagnostic levels of AKTS473 could be a novel biomarker in AML.
Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia
Authors: Morita Kiyomi , Kantarjian Hagop M. , Wang Feng , Yan Yuanqing , Bueso-Ramos Carlos , Sasaki Koji , Issa Ghayas C. , Wang Sa , Jorgensen Jeffrey , Song Xingzhi , Zhang Jianhua , Tippen Samantha , Thornton Rebecca , Coyle Marcus , Little Latasha , Gumbs Curtis , Pemmaraju Naveen , Daver Naval , DiNardo Courtney D. , Konopleva Marina , Andreeff Michael , Ravandi Farhad , Cortes Jorge E. , Kadia Tapan , Jabbour Elias , Garcia-Manero Guillermo , Patel Keyur P. , Futreal P. Andrew , Takahashi Koichi
Published: April 2018

Purpose

The aim of the current study was to determine whether the degree of mutation clearance at remission predicts the risk of relapse in patients with acute myeloid leukemia (AML).

Patients and Methods

One hundred thirty-one previously untreated patients with AML who received intensive induction chemotherapy and attained morphologic complete remission (CR) at day 30 were studied. Pretreatment and CR bone marrow were analyzed using targeted capture DNA sequencing. We analyzed the association between mutation clearance (MC) on the basis of variant allele frequency (VAF) at CR (MC2.5: if the VAF of residual mutations was < 2.5%; MC1.0: if the VAF was < 1%; and complete MC [CMC]: if no detectable residual mutations) and event-free survival, overall survival (OS), and cumulative incidence of relapse (CIR).

Results

MC1.0 and CMC were associated with significantly better OS (2-year OS: 75% v 61% in MC1.0 v non-MC1.0; P = .0465; 2-year OS: 77% v 60% in CMC v non-CMC; P = .0303) and lower CIR (2-year CIR: 26% v 46% in MC1.0 v non-MC 1.0; P = .0349; 2 year-CIR: 24% v 46% in CMC v non-CMC; P = .03), whereas there was no significant difference in any of the above outcomes by MC2.5. Multivariable analysis adjusting for age, cytogenetic risk, allogeneic stem-cell transplantation, and flow cytometry–based minimal residual disease revealed that patients with CMC had significantly better event-free survival (hazard ratio [HR], 0.43; P = .0083), OS (HR, 0.47; P = .04), and CIR (HR, 0.27; P < .001) than did patients without CMC. These prognostic associations were stronger when preleukemic mutations, such as DNMT3A, TET2, and ASXL1, were removed from the analysis.

Conclusion

Clearance of somatic mutation at CR, particularly in nonpreleukemic genes, was associated with significantly better survival and less risk of relapse. Somatic mutations in nonpreleukemic genes may function as a molecular minimal residual disease marker in AML.
The Vortex
Authors: Rivera José Eustasio
Published: April 2018

Published in 1924 and widely acknowledged as a major work of twentieth-century Latin American literature, José Eustasio Rivera's The Vortex follows the harrowing adventures of the young poet Arturo Cova and his lover Alicia as they flee Bogotá and head into the wild and woolly backcountry of Colombia. After being separated from Alicia, Arturo leaves the high plains for the jungle, where he witnesses firsthand the horrid conditions of those forced or tricked into tapping rubber trees. A story populated by con men, rubber barons, and the unrelenting landscape, The Vortex is both a denunciation of the sensational human-rights abuses that took place during the Amazonian rubber boom and one of the most famous renderings of the natural environment in Latin American literary history.
Experimental Beijing
Authors: Welland Sasha Su-Ling
Published: April 2018

During the lead-up to the 2008 Beijing Olympics, the censorious attitude that characterized China's post-1989 official response to contemporary art gave way to a new market-driven, culture industry valuation of art. Experimental artists who once struggled against state regulation of artistic expression found themselves being courted to advance China's international image. In Experimental Beijing Sasha Su-Ling Welland examines the interlocking power dynamics in this transformational moment and rapid rise of Chinese contemporary art into a global phenomenon. Drawing on ethnographic fieldwork and experience as a videographer and curator, Welland analyzes encounters between artists, curators, officials, and urban planners as they negotiated the social role of art and built new cultural institutions. Focusing on the contradictions and exclusions that emerged, Welland traces the complex gender politics involved and shows that feminist forms of art practice hold the potential to reshape consciousness, produce a nonnormative history of Chinese contemporary art, and imagine other, more just worlds.
Singly and Doubly Sulfone-Inserted Porphyrin Arch-Tape Dimers
Authors: Fukui Norihito , Osuka Atsuhiro
Published: April 2018

A singly sulfone-inserted porphyrin arch-tape dimer was synthesized from 2-iodoporphyrin via stepwise transformations consisting of palladium-catalyzed cross-coupling reaction with bis(tributylstannyl) sulfide, tungsten-catalyzed oxidation with hydrogen peroxide, and oxidative fusion with AuCl3 and AgOTf. This new synthetic protocol enabled the synthesis of doubly sulfone-inserted arch-tape dimer as the first example of arch-tape dimer containing two neighboring seven-membered rings. These sulfone-inserted porphyrin arch-tape dimers were fully characterized by X-ray crystal structural analysis, NMR and UV/Vis/NIR absorption spectroscopies, cyclic voltammetry, and theoretical calculations. Furthermore, arch-to-arch inversion dynamics of arch-tape dimers were examined by subjecting newly synthesized mesityl-substituted porphyrin arch tapes to the variable temperature 1H NMR measurements.
Introduction Roman populaire, culture mediatique et transferts culturels franco-grecs
Authors: Marcou Loïc
Published: April 2018

La dénomination de littérature populaire renvoie en France à une réalitémultiforme. Désignant aussi bien – selon les trois acceptions qu’onlui reconnaît – ce qui vient du peuple, ce qui lui est destiné que ce quiest aimé de lui, l’adjectif « populaire » caractérise à la fois la littératureorale, autrement celle qui porte la voix du peuple (contes, chansons), lalittérature de colportage (romans de la Bibliothèque bleue, placards,almanachs, etc.), en d’autres termes tout type d’écrit destiné au peuple, etla littérature grand public, entendons par là celle qui est aimée d’un largelectorat qui ne se confond pas nécessairement avec le « peuple » au senssocial du mot.
Les Mystères de Paris et la mondialisation d’un genre « populaire » ? Lecteurs de « mystères » en France, en Grèce et en Grande-Bretagne au XIXe siècle
Authors: Katsanos Filippos
Published: April 2018

Le phénomène de mode littéraire inauguré par la publication du roman d’Eugène Sue Les Mystères de Paris en 1842-3, a souvent été analysé par le recours à la notion de « littérature populaire » qui, dans la majorité des cas, se rapporte davantage à une poétique textuelle particulière qu’à une réalité sociale: les innombrables « mystères » écrits en imitation de ceux de Sue seraient « populaires » parce qu’ils appartiendraient à la « paralittérature », cet ensemble d’oeuvres considéré comme ayant une moindre valeur esthétique et dont les auteurs auraient abandonné la quête d’originalité en choisissant une écriture fondée sur la reprise et le remaniement de divers clichés narratifs. Or qu’en est-il de la « popularité » des mystères au sens strictement sociologique du terme ? Cet article propose d’étudier les lectorats des mystères dans trois pays qui ne connaissent pas les mêmes évolutions dans leurs systèmes éditoriaux respectifs : la France, la Grèce et la Grande-Bretagne. Nous essaierons de montrer que les mystères en tant que genre littéraire pérenne ne peuvent en aucun cas être étudiés à partir d’une hypothèse sociologique unique. Ni proprement « bourgeois » ni « populaires », ils épousent les évolutions complexes des contextes socio-culturels des différents pays en s’adaptant avec souplesse à leurs spécificités ainsi qu’aux diverses situations de communication.
The King, the Junta and the “Impartial Broker”: A microscopic approach to the Johnson-Constantine meeting on 11 September 1967
Authors: Kallivretakis Leonidas
Published: April 2018

This article explores the relations between the Greek military regime and King Constantine, as they evolved during the first months after the April 1967 coup, focusing on the part played by the “American factor”. Tracing step-by-step Constantine’s contacts with US officials, from his conversations with the American Ambassador in Athens to his meeting with President Johnson, the author investigates the King’s perception of the US government’s position regarding a possible confrontation between him and the colonels and how that perception influenced Constantine’s final decision to launch a counter-coup in December 1967.
Changes in Phytochemical Content During Different Growth Stages in Tubers of Five Varieties of Potato (Solanum Tuberosum L.)
Authors: Kipkoech Kirui Geoffrey , Fidahussein Dossaji Saifuddin , Onzere Amugune Nelson
Published: April 2018

Potato (Solanum tuberosum L.) synthesizes a variety of bioactive metabolites including phenolic compounds and glycoalkaloids that protects against insects and diseases, and may influence its nutritional quality. Phenolics provide valuable health promoting antioxidants, whereas glycoalkaloid concentrations exceeding the upper safety limit of 20 mg/100 g fresh weight (Fwt) are potential neurotoxins. Therefore, efficient selection for tuber nutritional quality is dependent upon safe and reliable analytical methods. The aim of this study was to determine the changes in the concentration of glycoalkaloids and phenolic compounds during different growth stages in tubers of five selected potato varieties grown in Kenya. α-chaconine and α-solanine were separated and identified by HPLC. Total glycoalkaloids (TGA) and phenolics were determined by UV spectrophotometry. Recovery efficiencies for validation of analytical methods ranged from 85.9-93.5%. Significant differences in TGA and phenolic contents were detected among potato varieties. Tuber TGA content ranged from 6.80 to 10.56 mg/100g Fwt in vars. Dutch Robijn and Tigoni, respectively, and were within the upper safety limit. The corresponding values for chlorogenic acid contents in the examined varieties ranged from 46.39 to 58.04 mg/100 g Fwt. Total phenolic concentration in the examined tuber extracts varied ranged from 129.24 to 192.52 mg CGA/g Fwt. Glycoalkaloid and phenolic production were significantly reduced from time of initiation to maturity at 55 and 125 days, respectively, after planting (DAP). These results demonstrate that tuber phytochemicals were strongly influenced by variety and level of maturity. For nutritional safety and quality purposes, harvesting of mature potato tubers after 125 DAP is recommended.
Inhibitory Activity of Cashew Apple (Anacardium Occidentale) Extract Marinade on The Meat Total Bacteria
Authors: Susanti S. , Setiani B. E. , Rizqiati H. , Febriandi D. R. , Bintoro V. P. , Setiani B. E.
Published: April 2018

Microbial activities cause physical and functional alteration, which can decrease the quality and shelf life of meat. Inhibiting the bacterial growth becomes a crucial effort to prevent spoilage of meat. Previous studies reported that human pathogen bacterias could be inhibited by using cashew apple juice. It was interested to explore the utilization of cashew apple as marinade solution to suppress the meat bacteria. Current study was aimed to get more insight the effectiveness of cashew apple extract marinade (CAM) as growth inhibitor for spoilage bacteria on beefs and chickens. Results indicated that inhibition zone of 20% CAM were significant higher than 0% CAM on the medium of E. coli, and S. aureus. The pretty high polyphenols content in CAM was considered as an active compound responsible for antibacterial activity. Furthermore, total bacterial count assay showed that 10 to 30% CAM significantly reduced the beef total bacteria in comparison to 0% while 15 % CAM significantly decreased the chicken total bacteria. It was suggested the range of effective level of CAM to reduce the meats bacteria is 10 to 30%. Thus, cashew apple can be a promising natural food preservative in the future, especially for extending the shelf life of meat.
Impact of Dietary Pattern on Glycemic Level Among Type 2 Diabetic Patients
Authors: Habib Farah , M. Durrani Anisa.
Published: April 2018

Diabetes is a lifelong progressive disease. Compliance to a healthy eating pattern is the corner-stone to maintain or reduce body weight and achieve good glycemic control (HbA1c 7%) which can delay and prevent diabetes related complications. The purpose of the present study is to find the relation between dietary pattern and glycemic level among type 2 diabetic patients. The information was gathered through 9 items dietary compliance questionnaire and 24-hour dietary recall method, and the glycemic level was measured by glycosylated hemoglobin (HbA1c). Type 2 diabetic patients aged 30-60 years, with no comorbidity and minimum of six months duration of diabetes from Jawaharlal Nehru Medical College were selected. The hierarchical regression analysis showed that dietary compliance 12.6% significantly predicted HbA1c (Δ R2= .126, F Change= 28.48, β= -.400, p .001). Only 43.5% of patients always followed the dietary regimen and 48.5% of patients usually followed it with HbA1c level of 7% to 7.3% respectively. It was concluded from the results that compliance to a dietary regimen was inversely related to the glycemic level of the patients.
Nutritional Status Improvement in Malnourished Rat (Rattus norvegicus) after Seluang Fish (Rasbora spp.) Treatment
Authors: Triawanti Triawanti , Yunanto Ari , Dwi Sanyoto Didik , Wana Nuramin Hendra
Published: April 2018

Prevalence of malnutrition in Indonesia is still high although it has some potential source of nutrients. Seluang fish (Rasbora spp.) is a river fish consumed by the people of South Kalimantan, Indonesia. This study analyzed the improvement of nutritional status in the malnourished rats after treatment with Seluang Fish. The study used malnourished white rats (Rattus norvegicus) using a low protein and fat diet for 8 weeks. The rats were divided into three groups; malnourished group (M) without other dietary treatment, standard diet (P1) and seluang diet (P2) for a period of four weeks. The malnourished group was sacrificed first, and after four weeks treatment, other groups were sacrificed; blood and bones were taken for weight, protein levels, hemoglobin levels, bone length, bone calcium levels and IGF-1 levels. The results showed that the average of body weight for all the studied groups ranged between 190 to 220g. Seluang diet had the highest serum protein levels (4.388 mg/dL), hemoglobin (19.7 mg/dL) and IGF levels (388.7 ng/mL). Standard diet had the longest bone length (3.547 cm) and the highest Calcium levels of 1.68 mg/g. Based on these results, it was concluded that Seluang fish may have the potential to improve the nutritional status of malnourished rats.
Microbial, Chemical and Sensorial Quality of Chilled Marinated Green Mussel Pernaviridis, (Linnaeus, 1758)
Authors: C. Sorio Jerson , I. Inolino Reyda
Published: April 2018

The study aimed to assess the physico-chemical, microbiological and sensorial quality of marinated green mussels (Perna viridis) over 28 days (4 weeks) storage period at chilled temperature (2 °C). There were two treatments in the study. In treatment 1, samples were immersed in 66% vinegar and 2% salt. In treatment 2, samples were immersed in 66% vinegar, 2% salt and 1% spices such as pepper, fennel, cloves, bay leaves and paprika. Based on the physico-chemical results, the sample has a proximate composition of 13.60% protein, 1.66% lipid and 0.07% moisture. For the TVB-N value, treatment 1 decreased from 4.35 mg/100g to 1.05 mg/100g over the 4 weeks storage period. In treatment 2, TVB-N value increased from week 1 (4.14 mg/100g) to week 2 (5.38 mg/100g), but decreased further from week 2 to week 4 with a TVB-N value of 1.62 mg/100g. For pH level determination, treatment 1increased its pH level from 4.03 to 4.13 over the storage period. In treatment 2, pH has increased from 4.2 (week 1) to 4.37 (week 3), but decreased further to 4.1 (week 4). There was no significant difference (p 0.05) observed between the samples. Based on the microbiological analyses, treatment 1 decreased it microbial count from 1.69 x 108 to 7.70 x 103 over the storage period. In treatment 2, the microbial count also decreased from 1.13 x 107 to 8.07 x 103. For the basis of sensory evaluation, treatment 1 decreased its general acceptability from 6.44 to 5.89 over the storage period. In treatment 2, the general acceptability also decreased from 6.67 to 5.71. According to the overall results, the marinated green mussel was stable for 28 days.
Fortification of Wheat Flour With Ragi Flour: Effect on Physical, Nutritional, Antioxidant and Sensory Profile of Noodles
Authors: Bhalerao Prasanna P. , Chaudhari Nikita S. , Muley Abhijeet B. , Talib Mohammed I. , Parate Vishal R. , Kudake Dnyaneshwar C.
Published: April 2018

The utilization of ragi flour for noodles preparation can be ideal due to its higher dietary fiber and essential minerals content. Therefore, the current work was focused to prepare high nutrients noodles by supplementing ragi flour in wheat flour at 10, 20, 30, and 40% levels. The fortified uncooked noodles showed an increase in steady diameter from 1.23+0.03mm to 2.33±0.06mm with a gradual decrease in lightness and whiteness index from 45.46±1.23 to 32.38±1.27 and 43.07±1.06% to 31.09±1.14%, with respective increase of ragi flour. The moisture content of uncooked noodles decreased steadily, while minor changes were observed in fat and ash content. Significant increase in protein (1.06 to 1.25 folds) and crude fiber content (1.64 to 3.62 folds) was noticed in ragi flour noodles in correlation to the control, respectively. The ragi flour fortified noodles not only had a prominent DPPH and ABTS radical scavenging activity but also increased phenolics content. The sensory studies depicted that a maximum of 20% ragi flour can be integrated in the noodles to attain desired overall acceptability and that was further verified by t-test at significance level p 0.05.
Drying Kinetics and Activation Energy of Asparagus Root (Asparagus racemosus Wild.) for Different Methods of Drying
Authors: Kohli Deepika , Shahi Navin Chand , Kumar Ajit
Published: April 2018

Drying reduces the water activity of food product and hence increases the shelf life of the food. In the present study, fresh asparagus roots were pretreated in hot water at 80oC for 5 min. The methods of drying used for the study were tray drying, solar drying, vacuum drying and fluidized bed drying at four temperature levels 40, 50, 60 and 70oC. The complete drying of asparagus follow falling rate period only. The total time for drying decreases with increase in temperature of drying air from 40oC – 70oC. Fluidized bed dryer has a highest average drying rate as compare to tray dryer, solar dryer and vacuum dryer. Four empirical models, namely Page’s, Exponential, Generalized exponential and Logarithmic model were fitted in the drying data to describe the phenomena of drying process using a linearized regression technique. It was found that the Page’s model was best as it describe most precisely about the drying behavior of asparagus roots. The effective moisture diffusivity of asparagus roots varies from 7.14 × 10-9 to 3.70 × 10-8 m2/s and it was also found that diffusivity increases with increase in temperature. The activation energy was found to be from 11.797 to 30.318 kJ/mol.
Aquifer Characterization A Scientific Imperative in Analysis of Water Level Trend – A Case Study from Northern Punjab, India
Authors: Krishan Gopal , Rao M.S. , Singh R.P. , Chopra R.P.S. , Takshi K.S.
Published: April 2018

Groundwater balance helps assessment of groundwater sustainability at the current rate of its use. The estimate is specific to the area and time reference of its estimation. Dynamic groundwater head which relates to the change in storage is an important parameter in the resource estimation. In case, the observation boreholes tap aquifers different from the getting abstracted, the estimated results may deviate drastically from its true value. Multiple aquifer system exists in the northern part of district Amritsar, Punjab, India for which the water level trends of representative well hydrographs in the region for the period January 2006 to December 2013, show moderate sustainability. Taking the case of Amritsar district of Punjab, it has been shown in the present study that if the aquifer details are not considered appropriately, the moderately sustainable groundwater system can get assessed as over-exploited aquifers. In the study, groundwater quality for irrigation needs is also been examined.
SOBRE O AUTORRETRATO: SENTIDOS EM JOGO NO ESPAÇO AUTOBIOGRÁFICO
Authors: FIGUEIREDO Eurídice , MORAES Luciano Passos
Published: April 2018

A noção de autorretrato, originária do universo das artes visuais, ainda éum gênero pouco explorado criticamente nas escritas de si. A multiplicidadede sentidos evocada pelo termo revela a tensão entre autobiografia e ficção,sublinhando sua importância nos estudos acerca da autofabulação. A partirda leitura de L’amour du lointain, de Sergio Kokis, serão abordadas algumasquestões-chave a respeito do conceito de autorretrato literário, com o objetivode analisar mais de perto os mecanismos postos em jogo na construção do espaçoautobiográfico de que faz parte o escritor migrante em questão.
PATRICK MODIANO: EM BUSCA DO SENTIDO
Authors: CAMPOS Laura Barbosa
Published: April 2018

O trabalho aborda o universo literário de Patrick Modiano (1945), escritorfrancês de origem judaica e prêmio Nobel de literatura em 2014. Toda a obrado autor articula-se em torno do período da Ocupação nazista em seu país,inscrevendo-se no contexto da literatura francesa da Segunda Geração deescritores judeus, também denominada de geração pós-Shoá, designando tantoaqueles que viveram a Segunda Guerra Mundial quando muito crianças quantoos que nasceram logo em seguida. Após breves considerações sobre a obrade Modiano, procuro analisar como a judeidade se relaciona com seus textos,assim como o trabalho de construção de sentido operado pela reconfiguração deinstâncias paternas e pela memória. Mostro que o período histórico mencionadoe o comportamento ambivalente do pai do escritor forjaram o imaginário daShoá na literatura de Patrick Modiano.
MARCEL PROUST POR ALVARO LINS
Authors: MAGALHÃES Pedro Armando de Almeida
Published: April 2018

A obra de Marcel Proust foi alvo de vários estudos no Brasil, dentre os quais sedestaca o ensaio do crítico de jornal Alvaro Lins, que publica em 1956 A técnicado romance de Marcel Proust. Nesse trabalho, Alvaro Lins busca examinar emque medida A la recherche du temps perdu se enquadraria no gênero romance,valendo-se da análise que Sainte-Beuve faz à obra de Balzac. Ora, é curioso queLins tenha fundamentado seu ensaio justamente em tal crítico francês, pois estehavia sido alvo de duras críticas por parte do autor que busca analisar, MarcelProust, em Contre Sainte-Beuve. Cabe portanto averiguar como se resolve essaaparente contradição, e qual a proximidade ou distanciamento de Lins comrelação a seu modelo, Sainte-Beuve. Fazendo-se um paralelo entre os dois críticos, nota-se que Lins demonstra grande acuidade ao assinalar a complexidade de todo romance. Com respeito à Recherche, ressalta a circularidade da obra, sendo cuidadoso no exame das personagens ao assinalar com bastante propriedade a questão do fracionamento do eu, muito embora ainda pareça confundir a figura do narrador com a do autor. Taxado de impressionista por muitos, inclusive pelo colega Afrânio Coutinho, Alvaro Lins merece, no entanto, um olhar cuidadoso, por demonstrar grande perspicácia e erudição no ensaio sobre Proust, contribuindo assim para a evolução dos estudos literários no Brasil.
LEAD SOURCE ASSESSMENT BY ISOTOPIC AND ELEMENTARY COMPOSITION IN THE TRANSITION FROM PRISTINE TO POLLUTED CONDITION OF COASTAL SEDIMENTS / AVALIAÇÃO DAS FONTES DE PB PELAS COMPOSIÇÕES ISOTÓPICAS E ELEMENTARES DE SEDIMENTOS COSTEIROS NA TRANSIÇÃO DE CONDIÇÕES NATURAIS PARA POLUÍDAS
Authors: Cunha Bruno , Machado Wilson , Marra Ariadne , Araújo Daniel , Garnier Jérémie , Martins Alan , Saliba Bruno , Geraldes Mauro
Published: April 2018

The source assessments of metal contaminants are critical for a consistent management of coastal zones. In this work, lead (Pb) concentration and isotopic composition were determined in sediments from Angra dos Reis coast (Brazil) to evaluate the potential influence of contamination sources on Pb distribution. Estimated Pb enrichment factor superior to 1.64 suggested natural source predominance. Diagrams of 206Pb/207Pb ratio plotted against 208Pb/206Pb and 1/Pb ratios indicated a binary source mixing that was explained by marine and terrigenous influences. Only some specific sites fall close to anthropogenic Pb isotopes signatures (e.g., from urban effluents and gasoline). The lower Pb concentrations were associated with a marine carbonate dilution effect, as indicated by a negative relationship between Pb and Ca. Past dredging activities contributed to explain a diffuse occurrence of anthropogenic Pb isotopic signature. The overall results reveal the beginning of a transition from pristine to slightly-polluted condition. ResumoA avaliação das fontes dos contaminantes metálicos é fundamental para um bom gerenciamento das zonas costeiras. Neste trabalho, as concentrações e composições isotópicas do chumbo (Pb) foram determinadas em sedimentos do litoral de Angra dos Reis (Brasil) para avaliar a potencial influência das fontes de contaminação na distribuição de Pb. Fatores de enriquecimento de Pb de até 1,64 sugeriram predominância de fontes naturais. Diagramas da razão 206Pb/207Pb plotados contra as razões 208Pb/206Pb e 1/Pb indicaram uma mistura binária de fontes, que foi explicada por influências marinhas e terrígenas. Apenas alguns locais específicos possuem assinaturas isotópicas similares às antropogênicas (por exemplo, de efluentes urbanos e gasolina). As concentrações mais baixas de Pb foram associadas a um efeito de diluição pelo carbonato marinho, como indicado por uma relação negativa entre Pb e Ca. Atividades de dragagem no passado contribuíram para explicar uma ocorrência difusa da assinatura isotópica de Pb antropogênico. Os resultados, em geral, revelam o início de uma transição da condição natural para levemente poluída.
Artesanias audiovisuais e a produção de dramaturgias docentesdiscentes: negociações mediadas pelo digital em rede
Authors: Nolasco-Silva Leonardo , Lo Bianco Vittorio , Faria Lia
Published: April 2018

Nossa proposta é pensar, a partir do conceito de audiovisualidades, as possibilidades didáticas abertas pela cultura da convergência, seja nos cenários da Educação a Distância, seja nas paisagens da modalidade presencial. Para tanto, discutimos o papel da televisão de modo a problematizar as tecnologias educacionais e seus usos por professores e estudantes. Discutimos o nosso contato diário com a televisão comercial – no aparelho tradicional ou na palma da nossa mão – e rememoramos iniciativas que elegeram a TV como meio de praticar e dar acesso à educação formal – mais especificamente falamos da gênese e da lógica do Telecurso 2º Grau, pensando em como aquela modalidade de ensino ainda ressoa entre as práticas atuais de EAD. Perguntamos o que ainda temos a aprender com essa lógica de produção de imagens e que espaços de invenção podemos explorar a partir dela, ampliando o repertório sobre as tecnologias educacionais na formação de professores.
Formação ou Capacitação em TIC? Reflexões sobre as Diretrizes da UNESCO
Authors: Pretto Nelson De Luca , Passos Maria Sigmar Coutinho
Published: April 2018

Este artigo tem o objetivo de refletir sobre as concepções de formação de professores na área de Tecnologias da Informação e Comunicação (TIC) e Educação tomando como principal fonte para análise o documento da UNESCO intitulado “Padrões de Competência em TIC para Professores”. Lançado em 2008, tal publicação pode trazer elementos para compreensão acerca das políticas de formação de professores em diversos países, inclusive no Brasil. Neste sentido, buscamos estabelecer os possíveis nexos entre essas diretrizes e os direcionamentos adotados para a formação de professores nas políticas de inserção das TIC nas escolas tomando como objeto os documentos referentes ao Programa Nacional de Formação Continuada em Tecnologia Educacional - Proinfo Integrado. A metodologia consiste na análise de conteúdo dos documentos oficiais dos programas publicados pelas referidas instituições (UNESCO e MEC). Concluímos afirmando a defesa de uma perspectiva de formação que não se resuma à capacitação tecnológica, mas proporcione aos professores uma inserção ativa na cultura digital.
REMANDO POR UM RIO DE MEMÓRIAS E VIVÊNCIAS
Authors: Cardoso Aurea Alves
Published: April 2018

Os moradores do Araguaia são muito mais que testemunhas da Guerrilha do Araguaia. São sobreviventes, assim como os militantes do Partido Comunista do Brasil (PCdoB) que foram para a região organizar o movimento popular que visou por fim a Ditadura Civil-Militar. Trabalhando com a ideia de rizoma, afirmamos nesse texto a Vida de um povo que foi atingido pela repressão do Estado ao longo da Ditadura. Ou seja, afirmamos a resistência de uma gente que também foi presa, torturada, morta, desaparecida, expulsa de sua terra, teve a sua plantação (único meio de subsistência) e paiol de alimentos destruídos e sobreviveu. Muitos adoeceram, muitos “ficaram loucos” e mesmo assim suas feridas foram negadas. SobreVIVEMOS, a gente sabe dessas coisas! Contudo, queremos muito mais que nos ater em juntar o que restou. Sabemos e queremos VIVER com inventividade e beleza!
‘LUGARES DA MEMÓRIA’ DA DITADURA EMPRESARIAL-MILITAR REVISITADOS EM PETRÓPOLIS-RJ
Authors: Lima Patricia Ferreira de Souza , Grossi Diego
Published: April 2018

Se reconhecemos uma cidade criativa pela sua capacidade de solução de problemas sociais com inovação, a parceria entre o projeto de extensão “Cefet campus Petrópolis: histórias de um prédio público por excelência” e a Comissão Municipal da Verdade elaborou um roteiro de visita técnica mediada pelos locais da memória da ditadura empresarial-militar na cidade com o objetivo não só de sensibilizar o olhar turístico sobre a memória de repressão e da oposição na Cidade Imperial, mas também para que, em caráter de turismo pedagógico, professores da rede pública e alunos de graduação em Turismo, conectassem com este período histórico para que nunca mais seja esquecido. As visitas técnicas mediadas fizeram parte da programação da II Semana da Memória, Verdade e Justiça, em abril de 2017.
Disputas e limites da Comissão da Verdade no Brasil
Authors: Salgado Livia De Barros
Published: April 2018

As primeiras medidas brasileiras na formulação de políticas de memória e tentativas de resignificar o passado autoritário datam os anos 1990, muito em função da pressão exercida por familiares de mortos e desaparecidos e perseguidos políticos. A forma como se dava o debate a respeito da ditadura no país, até então, não garantia o acesso à verdade àqueles que sofreram violência. Com o estabelecimento da Comissão Nacional da Verdade, em 2012, esse passou a ser o objetivo. Porém, muitos foram os dilemas enfrentados para que a proposta fosse colocada em prática, o que acabou por refletir na forma como essa “verdade” foi  formulada e na realização dos trabalhos da Comissão.. Diante do exposto, o objetivo desse artigo é analisar o processo de instauração da CNV, apresentando as disputas políticas que a envolveram, além das críticas dirigidas aos seus trabalhos. Palavras-chave: comissão nacional da verdade; disputas políticas; limites
As tragédias dos bairros onde moram
Authors: Batista Vera Malaguti
Published: April 2018

O presente artigo trata dos desafios da "transição democrática" no Brasil a partir das permanências históricas do autoritarismo presentes na colonização, na escravidão e na constituição de uma República que aposta na manipulação do povo brasileiro contra seus desejos de emancipação e protagonismo político. Assistimos, com relação à questão criminal, a passagem de uma resistência à truculência no fim da ditadura à sua naturalização e agora ao  aplauso legitimado pela "guerra às drogas" e o deslocamento do "inimigo interno" dos "subversivos" para os "traficantes". O GTNM-RJ constituiu-se nesse cenário em "dique utópico à barbárie" ao compreender as novas demandas por ordem e posicionar-se firmemente na luta pelos direitos atingidos pelas políticas criminais contemporâneas. Palavras-chaveviolência, controle social, criminologia, direito
A memória do corpo calado: das cenas, das questões e dos processos de uma filosofia do cotidiano
Authors: Teles Edson
Published: April 2018

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus a tortor nisi. In hac habitasse platea dictumst. Nunc congue libero sit amet mauris ultrices laoreet. Praesent velit neque, lacinia non pulvinar quis, sollicitudin nec metus. Etiam pharetra placerat arcu id ullamcorper. Mauris euismod lectus at quam dapibus pretium. In eros erat, ultricies a tempus eget, lacinia iaculis ex. Vestibulum quis justo cursus, vulputate risus eget, porta neque. Sed lectus magna, vestibulum ut dapibus ut, tristique a purus. Pellentesque tempus lacinia elit, vel accumsan augue ultricies eu. Sed ut ornare quam, nec rhoncus ante. Cras volutpat ligula leo, vitae fringilla ligula luctus non. Maecenas pharetra dolor sed ex cursus cursus.Nullam eu ultrices elit, vel sollicitudin dui. Donec convallis, velit in euismod placerat, ligula sem varius est, vitae cursus mauris neque nec est. Donec orci urna, eleifend sit amet ante eu, pulvinar tempus diam. Nulla convallis tellus risus, quis gravida magna sollicitudin non. In eu lorem tincidunt, condimentum magna in, molestie nunc. Etiam eget massa ac nisi ultrices ultricies. Quisque eget augue et ex egestas scelerisque. Aenean vitae lorem dictum, porta mi id, finibus mauris. Vivamus leo odio, semper vitae mi et, vehicula viverra neque. Vivamus lobortis enim sed mi tempor vehicula. Suspendisse ac libero id sapien pellentesque vestibulum vitae a ligula. Pellentesque rutrum velit eu odio efficitur interdum. Ut at massa ac mi gravida facilisis in eget nisl. Ut tincidunt arcu at ex suscipit, sed aliquet dui faucibus. Morbi metus lacus, auctor at enim et, congue viverra neque. Duis varius tincidunt magna quis eleifend.Donec non justo ac massa convallis bibendum. Maecenas efficitur pharetra blandit. Nulla venenatis neque vel felis laoreet, lacinia posuere velit porttitor. Phasellus viverra magna id dolor facilisis pellentesque. Etiam sapien nulla, efficitur et felis ut, dapibus vulputate dolor. Cras ac odio eget elit ornare mattis. Nam.
Empresariado e ditadura no Brasil: o estado atual da questão e o caso dos empreiteiros de obras públicas
Authors: Campos Pedro Henrique Pedreira
Published: April 2018

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus a tortor nisi. In hac habitasse platea dictumst. Nunc congue libero sit amet mauris ultrices laoreet. Praesent velit neque, lacinia non pulvinar quis, sollicitudin nec metus. Etiam pharetra placerat arcu id ullamcorper. Mauris euismod lectus at quam dapibus pretium. In eros erat, ultricies a tempus eget, lacinia iaculis ex. Vestibulum quis justo cursus, vulputate risus eget, porta neque. Sed lectus magna, vestibulum ut dapibus ut, tristique a purus. Pellentesque tempus lacinia elit, vel accumsan augue ultricies eu. Sed ut ornare quam, nec rhoncus ante. Cras volutpat ligula leo, vitae fringilla ligula luctus non. Maecenas pharetra dolor sed ex cursus cursus.Nullam eu ultrices elit, vel sollicitudin dui. Donec convallis, velit in euismod placerat, ligula sem varius est, vitae cursus mauris neque nec est. Donec orci urna, eleifend sit amet ante eu, pulvinar tempus diam. Nulla convallis tellus risus, quis gravida magna sollicitudin non. In eu lorem tincidunt, condimentum magna in, molestie nunc. Etiam eget massa ac nisi ultrices ultricies. Quisque eget augue et ex egestas scelerisque. Aenean vitae lorem dictum, porta mi id, finibus mauris. Vivamus leo odio, semper vitae mi et, vehicula viverra neque. Vivamus lobortis enim sed mi tempor vehicula. Suspendisse ac libero id sapien pellentesque vestibulum vitae a ligula. Pellentesque rutrum velit eu odio efficitur interdum. Ut at massa ac mi gravida facilisis in eget nisl. Ut tincidunt arcu at ex suscipit, sed aliquet dui faucibus. Morbi metus lacus, auctor at enim et, congue viverra neque. Duis varius tincidunt magna quis eleifend.Donec non justo ac massa convallis bibendum. Maecenas efficitur pharetra blandit. Nulla venenatis neque vel felis laoreet, lacinia posuere velit porttitor. Phasellus viverra magna id dolor facilisis pellentesque. Etiam sapien nulla, efficitur et felis ut, dapibus vulputate dolor. Cras ac odio eget elit ornare mattis. Nam.
O tacão das botas e as amizades: as políticas do olhar entre o poder a resistência
Authors: Mizoguchi Danichi Hausen
Published: April 2018

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus a tortor nisi. In hac habitasse platea dictumst. Nunc congue libero sit amet mauris ultrices laoreet. Praesent velit neque, lacinia non pulvinar quis, sollicitudin nec metus. Etiam pharetra placerat arcu id ullamcorper. Mauris euismod lectus at quam dapibus pretium. In eros erat, ultricies a tempus eget, lacinia iaculis ex. Vestibulum quis justo cursus, vulputate risus eget, porta neque. Sed lectus magna, vestibulum ut dapibus ut, tristique a purus. Pellentesque tempus lacinia elit, vel accumsan augue ultricies eu. Sed ut ornare quam, nec rhoncus ante. Cras volutpat ligula leo, vitae fringilla ligula luctus non. Maecenas pharetra dolor sed ex cursus cursus.Nullam eu ultrices elit, vel sollicitudin dui. Donec convallis, velit in euismod placerat, ligula sem varius est, vitae cursus mauris neque nec est. Donec orci urna, eleifend sit amet ante eu, pulvinar tempus diam. Nulla convallis tellus risus, quis gravida magna sollicitudin non. In eu lorem tincidunt, condimentum magna in, molestie nunc. Etiam eget massa ac nisi ultrices ultricies. Quisque eget augue et ex egestas scelerisque. Aenean vitae lorem dictum, porta mi id, finibus mauris. Vivamus leo odio, semper vitae mi et, vehicula viverra neque. Vivamus lobortis enim sed mi tempor vehicula. Suspendisse ac libero id sapien pellentesque vestibulum vitae a ligula. Pellentesque rutrum velit eu odio efficitur interdum. Ut at massa ac mi gravida facilisis in eget nisl. Ut tincidunt arcu at ex suscipit, sed aliquet dui faucibus. Morbi metus lacus, auctor at enim et, congue viverra neque. Duis varius tincidunt magna quis eleifend.Donec non justo ac massa convallis bibendum. Maecenas efficitur pharetra blandit. Nulla venenatis neque vel felis laoreet, lacinia posuere velit porttitor. Phasellus viverra magna id dolor facilisis pellentesque. Etiam sapien nulla, efficitur et felis ut, dapibus vulputate dolor. Cras ac odio eget elit ornare mattis. Nam.
Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma
Authors: Lawrenz J. M. , Styron J. F. , Parry M. , Grimer R. J. , Mesko N. W.
Published: April 2018

Aims

The primary aim of this study was to determine the effect of the duration of symptoms (DOS) prior to diagnosis on the overall survival in patients with a primary bone sarcoma.

Patients and Methods

In a retrospective analysis of a sarcoma database at a single institution between 1990 and 2014, we identified 1446 patients with non-metastatic and 346 with metastatic bone sarcoma. Low-grade types of tumour were excluded. Our data included the demographics of the patients, the characteristics of the tumour, and the survival outcome of patients. Cox proportional hazards analysis and Kaplan–Meier survival analysis were performed, and the survivorship of the non-metastatic and metastatic cohorts were compared.

Results

In the non-metastatic cohort, a longer DOS was associated with a slightly more favourable survival (hazard ratio (HR) 0.996, 95% confidence interval (CI) 0.994 to 0.998, p < 0.001). In all types of tumour, there was no difference in survival between patients with a DOS of greater than four months and those with a DOS of less than four months (p = 0.566). There was no correlation between the year of diagnosis and survival (p = 0.741). A diagnosis of chondrosarcoma (HR 0.636, 95% CI 0.474 to 0.854, p = 0.003) had the strongest positive effect on survival, while location in the axial skeleton (HR 1.76, 95% CI 1.36 to 2.29, p < 0.001) had the strongest negative effect on survival. Larger size of tumour (HR 1.05, 95% CI 1.03 to 1.06, p < 0.001) and increased age of the patient (HR 1.02, 95% CI 1.01 to 1.03, p < 0.001) had a slightly negative effect on survival. Metastatic and non-metastatic cohorts had similar median DOS (16 weeks, p = 0.277), although the median survival (15.5 months vs 41 months) and rates of survival at one year (69% vs 89%) and five years (20% vs 59%) were significantly shorter in the metastatic cohort.

Conclusion

A longer DOS prior to diagnosis is not associated with a poorer overall survival in patients with a primary bone sarcoma. Location in the axial skeleton remains the strongest predictor of a worse prognosis. This may be helpful in counselling patients referred for evaluation on a delayed basis. Cite this article: Bone Joint J 2018;100-B:652–61.
April is the cruellest month
Authors: Mortensen Neil
Published: April 2018

After a bitter winter, some slender shoots of hope are visible.
Reflections on ‘Project Transform’
Authors: Jackson Barry
Published: April 2018

Former RCS President Barry Jackson talks us through the story of the College’s transformation so far.
Dissection of plastic surgery national selection
Authors: Filobbos G , Sepehripour S , Kumar S
Published: April 2018

Owing to the popularity of plastic surgery as a career choice and the limited number of training posts, applicants need to be highly competitive. Preparation can start at an early stage and even as an undergraduate.
Cross-examination
Authors: Wheeler Robert
Published: April 2018

Each month we take a close look at a recent legal case with implications for the surgical profession.
Slop’s transmogrification to patient patient
Authors: Slop Mr
Published: April 2018

As old age looms, the operating tables are turning for our surgeon-author
Evaluation to support learning design: Lessons learned in a teacher training MOOC
Authors: Garreta-Domingo Muriel , Hernández-Leo Davinia , Sloep Peter B.
Published: April 2018

The design of learning opportunities is an integral part of the work of all educators. However, educators often lack the design skills and knowledge that professional designers have. One of these basic skills is related to the evaluation of produced artefacts, an essential step in all design frameworks. As a result, evaluation of learning activities falters due to this lack of knowledge and mindset. The present study analyses how in-service educators perceived and accomplished an evaluation activity aimed at promoting assessment prior to enactment. Heuristic evaluation is an inspection method considered to be one of the easiest to learn and yet is efficient, time and cost effective. These characteristics make it suitable for the design work of educators; which is, above all, practice-driven and practice-oriented. Results show that educators grasped the value of such an activity (solving possible second-order barriers) but struggled to understand how to do the specifics of the task (first-order barrier), which was to define their own set of educational heuristics. Based on the lessons learned, the paper finalises with a proposal for a design task to include evaluation to support learning design; empowering educators to assess both existing learning activities and ICT-tools as well as their own designs.
Analysis Possibilities of Controlled Transport of Moisture in Woven Fabrics
Authors: Sirková Brigita Kolčavová , Moučková Eva
Published: April 2018

The article is focused on testing of selected properties of linear and planar textiles from modified cotton yarns. In this article, the influence of woven fabric construction on wettability and possibilities of detection of moisture in the woven fabric is analyzed. Improving the physiological and hygienic properties for woven fabrics can be achieved with a specially designed textile structure in combination with a permanent surface finish of sub-set of yarns. Inserting of hydrophilic and hydrophobic set of threads in the woven structure makes possible controlled water transport. Controlled transport of water ensures good clothing comfort. Using such woven fabric, accumulation of water on the skin does not occur during the process of thermoregulation of the human body. The properties and behavior of the designed fabric will be determined by surface finishing of the warp and weft yarns (sub-set of yarns), which are supporting elements of the fabric.