bluuebunny/crossref_metadata_2025 huggingface dataset:
Ovarian Protection During Chemo- and Radio-Therapy
Authors: Della Martina Monica , Trombetta Giulia , Venier Martina , Cagnacci Angelo
Published: September 2022

Improvement in oncologic treatment has made the preservation of fertility of
young women surviving cancer a demanding issue. International guidelines
recommend reproductive counseling before surgery, chemotherapy or radiotherapy.
Information should deal with the different ways to preserve fertility, such as embryos,
oocytes or ovarian tissue cryopreservation, suppression of ovarian activity during
chemotherapy, or ovarian transposition/shielding during radiotherapy. Preservation of
fertility during chemotherapy depends on several factors such as ovarian reserve at the
moment of treatment, age, type of treatment, type of dose and posology of the drug
used. Data from the literature show that certain preservation of ovarian function can be
achieved by suppressing ovarian function with a GnRH analog (GnRHa) during
chemotherapy for breast cancer. However, there is no evidence that ovarian
preservation can be achieved by ovarian suppression during chemotherapy for
hematological neoplasms. In these cases, oocyte cryopreservation represents the only
available option. Ovarian damage after pelvic radiotherapy is related to age and the
dose of radiation delivered. Ovarian preservation can be achieved via the transposition
of the ovaries from the radiation field by a minimally-invasive surgical approach. Three
surgical techniques for ovarian transposition by laparoscopy were described with either
a lateral, a medial, or an anterior approach. In conclusion, nowadays it is possible to
allow reproduction in most young women surviving cancer by an individualized
approach that takes into consideration the type of malignancy, the type of treatment,
and the preventive measures that can be used in every single case.
Nanoparticle-aided AOP for Treatment of Benzoic Acid
Authors: Deshpande Bhavna D. , Agrawal Pratibha S. , Yenkie M.K.N. , Dhoble S.J.
Published: September 2022

Advanced oxidation process (AOP) degrades a number of non-degradable
organic compounds in low concentrations, saving time and energy. Benzoic acid and its
derivatives are readily used in pharmacy, textile, and dyes industries. Through these
applications, benzoin acid enters the ecosystem, which leads to its accumulation and
various health hazards. In the present study, the degradation of Benzoic acid was
studied using Iron nanoparticles as heterogeneous photocatalyst and hydrogen peroxide
as an oxidizing agent. This paper also discusses the synthesis of Fe nanoparticles via
hydrothermal process at ordinary temperature and elevated temperature. The powder
samples were characterized by X-ray diffraction (XRD), Scanning Electron Microscope
(SEM) and Energy dispersive analysis of X-rays (EDAX). The percentage degradation
of benzoic acid using goethite (α-FeOOH) and hematite (α-Fe2O3
) was 49.02% and
90.90% with the nano concentrations of 0.07g and 0.05g, respectively using visible
light, in addition, the hydrothermal model of nanoparticle synthesis proved affordable,
efficient and eco-friendly.
Handheld Computer Devices to Support Clinical Decision-making in Acute Nursing Practice: Systematic Scoping Review
Authors: Glanville David , Hutchinson Anastasia , Khaw Damien
Published: September 2022

Background

Nursing care is increasingly supported by computerized information systems and decision support aids. Since the advent of handheld computer devices (HCDs), there has been limited exploration of their use in nursing practice.

Objective

The study aimed to understand the professional and clinical impacts of the use of mobile health apps in nursing to assist clinical decision-making in acute care settings. The study also aimed to explore the scope of published research and identify key nomenclature with respect to research in this emerging field within nursing practice.

Methods

This scoping review involved a tripartite search of electronic databases (CINAHL, Embase, MEDLINE, and Google Scholar) using preliminary, broad, and comprehensive search terms. The included studies were hand searched for additional citations. Two researchers independently screened the studies for inclusion and appraised quality using structured critical appraisal tools.

Results

Of the 2309 unique studies screened, 28 (1.21%) were included in the final analyses: randomized controlled trials (n=3, 11%) and quasi-experimental (n=9, 32%), observational (n=10, 36%), mixed methods (n=2, 7%), qualitative descriptive (n=2, 7%), and diagnostic accuracy (n=2, 7%) studies. Studies investigated the impact of HCDs on nursing decisions (n=12, 43%); the effectiveness, safety, and quality of care (n=9, 32%); and HCD usability, uptake, and acceptance (n=14, 50%) and were judged to contain moderate-to-high risk of bias. The terminology used to describe HCDs was heterogenous across studies, comprising 24 unique descriptors and 17 individual concepts that reflected 3 discrete technology platforms (“PDA technology,” “Smartphone/tablet technology,” and “Health care–specific technology”). Study findings varied, as did the range of decision-making modalities targeted by HCD interventions. Interventions varied according to the level of clinician versus algorithmic judgment: unstructured clinical judgment, structured clinical judgment, and computerized algorithmic judgment.

Conclusions

The extant literature is varied but suggests that HCDs can be used effectively to support aspects of acute nursing care. However, there is a dearth of high-level evidence regarding this phenomenon and studies exploring the degree to which HCD implementation may affect acute nursing care delivery workflow. Additional targeted research using rigorous experimental designs is needed in this emerging field to determine the true potential of HCDs in optimizing acute nursing care.
Black-White Differences in the Protective Effects of Income against Perceived Financial Difficulties in the United States
Authors: Assari Shervin , Najand Babak
Published: September 2022

One of the components of the protective effects of overall high socioeconomic status (SES) on health is high subjective SES. As SES has shown weaker health effects for marginalized groups, a phenomenon called Marginalization-related Diminished Returns (MDRs), we conducted this study to test differential associations between two objective SES indicators, namely education and household income, with a subjective SES indicator (perceived financial difficulties) by race. For this cross-sectional analysis, we used the Health Information National Trends Survey (HINTS 2020) data. Participants included 1403 individuals who identified as either non-Latino Black or non-Latino White. Age, sex, marital status, and employment were used as control variables, while education and income were used as independent variables. Perceived financial difficulties were the outcome. Binary logistic regression was used for main data analysis. Linear regression was used for sensitivity analysis. Overall, high education and household income were associated with lower odds of perceived financial difficulties. We documented a statistical interaction between race and income on subjective SES indicating a weaker inverse association between household income and perceived financial difficulties for non-Latino Black than non-Latino White individuals. The results remained similar using linear or logistic regression models. We did not find racial differences in the association between education and perceived financial difficulties. In the US, and under structural racism, the link between objective SES indicators such as income and perceived financial difficulties differs for non-Latino Black and non-Latino White people. Income may better reduce perceived financial difficulties for non-Latino Black than non-Latino White individuals. This finding is in line with the MDRs framework and suggests a mechanism for why we observe weaker health effects of objective SES indicators, such as income, for racial minorities in the US, and why we observe racial health disparities across class lines.
Efficacy of the Examination of Saliva Sample by Reverse Transcriptase-Polymerase Chain Reaction in Detection of SARS-CoV-2 in Al-Fallujah City, Iraq
Authors: Al-Ani Hind Q. Jameel , Al-Hayani Noor N. , Al-Ani Raid M.
Published: September 2022

Saliva samples could be used as a non-invasive method to diagnose COVID-19. We aimed to assess the results of the reverse transcriptase-polymerase chain reaction (RT-PCR) of saliva specimens in the detection of COVID-19. We collected saliva and nasopharyngeal (NP) samples from consecutive COVID-19 suspects in Al-Fallujah Teaching Hospital, Anbar, Iraq from November 29, 2021 to February 15, 2022. The results of the two specimens were compared using RT-PCR. For the positive saliva tests, repetition of the test was undertaken at weekly intervals for four weeks from the time of the presentation. There were 55% men and 60% people ≤ 35 years. The majority of cases presented within 2-5 days (92%) and were of mild severity (89%). A hundred pairs of samples were taken. COVID-19 was diagnosed by NP swab RT-PCR in 56% and 31% of the saliva samples. The saliva samples had 100% sensitivity (95% confidence interval [CI] 60.4% e96.6%), 63.8% specificity (95% CI 96.1% e99.9%), and mild coefficient agreement (kappa coefficient = 0.522). The positive test for the saliva samples remained as such in all examined cases in the first and second weeks after the first test, 31/31 and 30/30, respectively. While half of them were positive in the third week (15/30). All cases became negative in the fourth week (0/15). We recommend not using the saliva swab as an alternative to the NP swab in the detection of the SARS-CoV-2 by RT-PCR. However, saliva sample can be used for the follow-up of the COVID-19 subjects, in children, elderly, and handicapped patients.
Anomaly Detection in Ambient Air Quality
Authors: Samuel Sneha
Published: September 2022

Abstract: In smart cities there are systems which monitor the air pollution levels at different locations. Supervising the information given by the gas sensor devices may be a tedious task because the sensor data is simply too huge to investigate manually. Further because of electrical interference and environmental conditions, the sensors may show false values and trigger alarms. Just in case the sensor gives any anomalous values then the values should be eliminated from analysis and triggering of alarms should be stopped. The damaged sensors must get replaced as early as possible. This paper proposes a Data Acquisition System (DAS) which measures humidity, temperature and air quality index at different locations. Just in case the sensor encounters some problem and provides anomalous values, it is detected in real time by comparing these values with predicted values of the ‘Moving Average Model’ in Python. These anomalous values can then be eliminated from analysis.
Covid-19 End and Peak Prediction Using Machine Learning
Authors: Praveen Sai , Kumar Ravi Kant
Published: September 2022

Abstract: The transmission of COVID-19 disease has shown a great impact on society. The whole world has been fighting this epidemic since late February 2020. The main objective of this project is to predict the spread and end of the COVID-19 disease. Because of the COVID-19 outbreak, the world's economy has been affected so far and an accurate prognosis of its epidemic is significant. Prediction for the end of this disease is not an easy task as it requires plenty of data and also various parameters involved in the prediction. This project proposes certain machine learning techniques and ARIMA models with numerical approximations from the dataset provided we forecast the number of reported cases and disease transmission.
Perspective Between Central And Regional Government Relations In Legal Problems To Handle Covid-19 Pandemic
Authors: Sabirin Ahmad , Adiyaksa Febrian Duta , Herfian Raafid Haidar
Published: September 2022

The purpose of this article is to describe the perspective between central and regional government relations in legal problems to handling a covid-19 pandemic. The important thing in a constitution is the desire for how the constitutional life of the nation is to be led, which can be seen in the structure and state administration system. There are differences appeared between central and local governments in handling covid-19 pandemic, such as the local lockdown or Pembatasan Sosial Berskala Besar (“PSBB”) policies implemented in several regions in Indonesia, even though Law No. 6 of 2018 concerning health quarantine, the application of PSBB is the central’s government authority. On the other hand, the implementation of PSBB is the responsibility of the regional government to protect society. It seems that the central government’s struggle was preceded by the regional government due to the slow pace of movement that occurred to handle the Covid-19 pandemic the central government. What are solutions to overcoming the legal problems or problems dealing with the Covid-19 pandemic related to the perspective of the relationship between central and regional governments? Normative law research is used as a research method, that conducting by examining library materials as secondary data. The result showed that there is a shared responsibility to handle covid-19 pandemic for both central and regional governments. To make sure that the Joint coordination’s role is done without the friction of authority, it is important to pay attention to the following rules: 1). If the scope of handling covid-19 pandemic is across provinces area. It is the central government’s authority, 2). If the scope of handling covid-19 pandemic is across regencies/cities area. It is the provincial government’s authority, 3). If the scope of handling covid-19 pandemic is in a district/city area, it becomes the district/city government’s authority.
Institusi Hukum Perwakafan Indonesia: Kajian Kelembagaan Badan Wakaf Indonesia (Sejarah dan Struktur Kelembagaan)
Authors: Luthfi Muhammad , Wardoyo Yohana Puspitasari , Kurniawan Kukuh Dwi , Esfandiari Fitria , Fajrin Yaris Adhial
Published: September 2022

Waqf is part of Islamic philanthropy, along with the development of time and circumstances, waqf processes and procedures developed according to the context of the times, not least the development of the rule of law governing waqf law, Law 41/2004 as a new waqf rule in Indonesia, with the spirit of increasing the productivity of waqf assets, and forming nazhir professionalism, then forming a new institution in the waqf world in Indonesia called Badan Wakaf Indonesia (BWI),  Hope with the establishment of BWI becomes the main driving force of representation and becomes a medium in increasing waqf assets for the welfare of the people. This paper discusses the history of the institutionalization of BWI institutions and their institutional rules in Law 41/2004. This paper is normative research with a statutory approach and a conceptual approach. The results of the study from this paper state that the history of the institutionalization of BWI is influenced by the factors of the concept of cash waqf and the factor of updating the concept of waqf management which is not only trying to maintain waqf assets but more to make waqf assets more productive. BWI institutional rules based on Law 41/2004 regulate the position, duties, structure, and diversity, the period of service of management, and rules on the performance process of BWI.
Evaluation of procedural and conceptual knowledge of mathematical functions: A case study from Morocco
Authors: Qetrani Safâ , Achtaich Naceur
Published: September 2022

To measure the procedural and conceptual knowledge of functions and to clarify the relationship between them in the context of mathematics education in Morocco, a structural equation modeling (SEM) analysis was used. In addition, correlation tests between students’ grades at their Mathematical Analysis Assessments and their procedural and conceptual knowledge of functions scores were established to investigate whether students' grades mainly reflect their performance on procedural knowledge or conceptual knowledge. The sample consisted of 337 high school Moroccan students. The study findings indicated that a large group of participants scored high in procedural tasks but low in conceptual tasks. Besides, the participants’ grades in their exams correlate much more strongly with the estimated procedural knowledge scores than the estimated conceptual knowledge scores. On the other hand, the confirmatory factor analysis of the SEM confirmed the reliability, validity, and fitness of the measurement model, whereas the path analysis of the SEM supports the genetic view causal relationship that procedural knowledge of functions is necessary but not sufficient condition for conceptual knowledge. These results provide a theoretical foundation for improving mathematics education by working on the content of the assessments, the teachers’ teaching approaches, and the students’ learning strategies.
Curiosity: A game-based early mathematics case
Authors: Rahayu Chika , Putri Ratu Ilma Indra , Zulkardi  , Hartono Yusuf
Published: September 2022

This research aimed to generate a learning trajectory in an introduction to early mathematics, precisely to measure learning using educational games and Realistic Mathematics Education (RME) and to describe young children’s curiosity in learning early mathematics. Children need to have an understanding to take a measurement and use a learning trajectory to learn how to differentiate measurable and countable quantities and to tell the longer and the greater in number. The design of this research involves three phases, namely, preliminary design, experimentation, and retrospective analysis. A Hypothetical Learning Trajectory (HLT) using educational games was developed by collecting data from documentation, observations, and interviews. The results obtained from the implementation in the classroom showed that the educational games were able to help young children get to know early mathematics, particularly on measurements of lengths and volumes. There is an association with several factors in the selection of realistic problems. Communications during the game could stimulate an introduction to measurement. The use of objects in students’ vicinity also contributed to their experiments relating to measurement. The results of this research inform policymaking for teachers in designing learning in the classroom in introducing early mathematics based on educational games and Realistic Mathematics Education (RME).
Composición, abundancia y distribución de cumáceos (Crustacea: Peracarida) en los Parques Nacionales de Isla Mujeres e Isla Contoy, Quintana Roo, México
Authors: Cházaro-Olvera Sergio , Winfield Ignacio , Ortiz Manuel , Pineda-Castillo Bexidiu Anai , Cházaro-Martínez Sergio José
Published: September 2022

En este estudio se evaluó la composición, distribución y abundancia de cumáceos colectados en los Parques Nacionales Isla Mujeres e Isla Contoy, Quintana Roo, México. Los especímenes fueron recolectados con una red de cuchara (0,30 m de ancho por 0,48 m de largo y 330 µm de apertura de malla). Los arrastres se realizaron sobre vegetación sumergida en transectos de 10 m de largo paralelos a la línea de costa. Adicionalmente, en una estación de Isla Mujeres se utilizó una trampa de luz blanca con una intensidad de 30 lm. Se midieron los parámetros fisicoquímicos in situ, los cuales estuvieron dentro de los valores establecidos por la norma oficial mexicana para aguas no contaminadas; temperatura (27,26 ± 0,64 °C); salinidad (35,65 ± 0,21); oxígeno disuelto (8,01 ± 0,88 mg L-1); sólidos disueltos (22,82 ± 0,22 ppm); y pH (8,07 ± 0,15). En cuanto a las familias Bodotriidae y Nannastacidae, se identificaron un total de 7.590 ejemplares pertenecientes a 5 géneros y 18 especies. Cumella sp. “A” fue la especie más abundante con 5.364 ejemplares seguida de Vaunthompsonia floridana con 1.391 ejemplares. Se registró Vaunthompsonia minor en 9 de las 11 estaciones de muestreo. Se amplió el rango geográfico de distribución de Cyclaspis mexicansis, Cumella achimae, C. bacescui, C. andri, C. caribbeana, C. croixensis, C. medeeae y C. somersi. La mayor diversidad y equidad se presentó en Isla Mujeres (3,05 y 0,88 bits ind-1, respetivamente). El género Vaunthompsonia fue dominante en Isla Mujeres, mientras que el género Cumella fue dominante en Isla Contoy.
Extendiendo la conversación sobre los juicios morales: contribuciones del intuicionismo social, el constructivismo y la psicología cultural
Authors: Barreiro Alicia Viviana , Castorina José Antonio
Published: September 2022

El objetivo de este trabajo es extender el diálogo entre el intuicionismo social, las perspectivas genéticas de la psicología moral, señalando las contribuciones y limitaciones de cada una de ellas para avanzar en la comprensión de la formulación y transformación de los juicios morales. Particularmente, se ha propuesto un examen del modo en el que han sido abordadas las relaciones entre el sujeto y el objeto de conocimiento a la luz de los aportes de la traducción psicológica constructivista. Además, se analizan las relaciones entre las emociones, el razonamiento y la situación sociales específicas en la que tienen lugar tales procesos cognitivos, a través de las contribuciones de la psicología cultural. Mediante tal examen fue posible apreciar la contribución indudable del intuicionismo social a la psicológica moral, sus limitaciones, y elucidar las tesis que conforman dicha teoría. Justamente, al examinar las relaciones, las convergencias y las profundas diferencias entre el intuicionismo social, el constructivismo y la psicología cultural en sus abordajes sobre el juicio moral es posible contribuir a promover su revisión y elucidación.
Por el camino de Hume. Resonancias humeanas en el modelo intuicionista social de Jonathan Haidt
Authors: Vidiella Graciela
Published: September 2022

Jonathan Haidt ha puesto de manifiesto en diversas publicaciones la influencia que tuvo Hume como inspirador de su modelo intuicionista social, en especial en lo referente a la raíz emocional e intuitiva que da origen al juicio moral. Este artículo se propone indagar en dicha influencia con el objetivo de analizar, revisar y comparar aquellos conceptos e hipótesis que puedan tener en común los programas los dos autores.
A partir de mostrar las semejanzas de ambos en el objetivo de investigar las raíces de la moralidad en la psicología, se analizan y comparan sus respectivas críticas al racionalismo y, en función de ellas, los supuestos intuicionistas que ambos asumen o podrían asumir. Dado que la motivación de los juicios morales es el tema prioritario en las investigaciones de Haidt, la parte central del trabajo está dedicada a él; al respecto se muestran las dificultades de Hume para conciliar su emotivismo con la corrección del juicio moral, a la que considera necesaria. Por último, se concluye que ambas posiciones poseen consecuencias normativas regidas por una ética de la virtud.
Intraoperative margin assessment of large breast specimens
Authors: Nakad Bothaina , Simovici Paula , Milevsky Daria , Brodsky Asia
Published: September 2022

We present here a case of the utility of Tomosynthesis in real time
during surgery for margin assessment. This vigorous planning of
operative steps allows one-step procedure with maximal outcome.
Numerical Analysis and Experimental Verification on Crack Growth and Fatigue Life in Double-Edge Cracked Metal Plates
Authors: Jen Ming-Hwa , Wu Yu-Jen , Wu Ying-Hui , Huang Wen-Pin
Published: September 2022

Grade 1 titanium plates with both symmetrically and anti-symmetrically
waisted cracks were due to tension tests first to receive the load vs.
displacement diagrams and mechanical properties of strength and
stiffness. Next from cyclic tests the load vs. cycles curves were
constructed and fatigue life obtained. The numerical analysis using
finite element method and ANSYS workbench was to yield the numerical
results of crack growth and life. From fracture mechanics the critical
crack length was considered as final failure, then the modified
numerical results were received. The results in load vs. cycles curves
from two numerical method was found within acceptable errors with the
experimental data.
SINGULARITIES OF DEVELOPABLE SURFACES IN LORENTZ 3-SPACE
Authors: Çetin Esma Demir , RAMİS ÇAĞLA , Yaylı Yusuf
Published: September 2022

In this work we investigate singularities for the three types of
developable surfaces, introduced by Izumiya and Takeuchi, in Lorentz 3
space and give a local classification in terms of k-order frame
[3,4]. Moreover we search the necessary conditions of being a
geodesic for principal direction curves of the rectifying developable
surface.
SCIENCE-DRIVEN GUIDELINES NEEDEDTO BETTER MANAGE AND CONSERVE AVIAN SCAVENGERS IN NORTH AMERICA
Authors: Rush Scott , Buckley Neil , Zollner Patrick , Kluever Bryan , McWherter Brooke , Burcham Grant , Ma Zhao , Wahl Marian , Naveda-Rodríguez Adrián
Published: September 2022

We identify critical science needed to understand conflict between black
vultures and humans to inform effective management of this species in
North America.
Single nucleotide variations encoding missense mutations in G protein-coupled receptors may contribute to autism.
Authors: Westhuizen Emma Therese Van Der
Published: September 2022

Autism is a neurodevelopmental condition with a range of symptoms that
vary in intensity and severity from person to person. Genetic sequencing
has identified thousands of genes containing mutations in autistic
individuals, which may contribute to the development of autistic
symptoms. Several of these genes encode G protein-coupled receptors
(GPCRs) which are cell surface expressed proteins that transduce
extracellular messages to the intracellular space. Mutations in GPCRs
can impact their function, resulting in aberrant signalling within
cells, and across neurotransmitter systems in the brain. This review
summarises the current knowledge on autism-associated single nucleotide
variations encoding missense mutations in GPCRs, and the impact of these
genetic mutations on GPCR function. For some autism-associated
mutations, changes in GPCR expression levels, ligand affinity, potency
and efficacy have been observed; however, for many the functional
consequences remain unknown. Thus, further work to characterise the
functional impacts of the genetically identified mutations is required.
Longitudinal Association of DNA Methylation With Type 2 Diabetes and Glycemic Traits: A 5-Year Cross-Lagged Twin Study
Authors: Hong Xuanming , Wu Zhiyu , Cao Weihua , Lv Jun , Yu Canqing , Huang Tao , Sun Dianjianyi , Liao Chunxiao , Pang Yuanjie , Pang Zengchang , Cong Liming , Wang Hua , Wu Xianping , Liu Yu , Gao Wenjing , Li Liming
Published: September 2022

Investigators of previous cross-sectional epigenome-wide association studies (EWAS) in adults have reported hundreds of 5′-cytosine-phosphate-guanine-3′ (CpG) sites associated with type 2 diabetes mellitus (T2DM) and glycemic traits. However, the results from EWAS have been inconsistent, and longitudinal observations of these associations are scarce. Furthermore, few studies have investigated whether DNA methylation (DNAm) could be modified by smoking, drinking, and glycemic traits, which have broad impacts on genome-wide DNAm and result in altering the risk of T2DM. Twin studies provide a valuable tool for epigenetic studies, as twins are naturally matched for genetic information. In this study, we conducted a systematic literature search in PubMed and Embase for EWAS, and 214, 33, and 117 candidate CpG sites were selected for T2DM, HbA1c, and fasting blood glucose (FBG). Based on 1,070 twins from the Chinese National Twin Registry, 67, 17, and 16 CpG sites from previous studies were validated for T2DM, HbA1c, and FBG. Longitudinal review and blood sampling for phenotypic information and DNAm were conducted twice in 2013 and 2018 for 308 twins. A cross-lagged analysis was performed to examine the temporal relationship between DNAm and T2DM or glycemic traits in the longitudinal data. A total of 11 significant paths from T2DM to subsequent DNAm and 15 paths from DNAm to subsequent T2DM were detected, suggesting both directions of associations. For glycemic traits, we detected 17 cross-lagged associations from baseline glycemic traits to subsequent DNAm, and none were from the other cross-lagged direction, indicating that CpG sites may be the consequences, not the causes, of glycemic traits. Finally, a longitudinal mediation analysis was performed to explore the mediation effects of DNAm on the associations of smoking, drinking, and glycemic traits with T2DM. No significant mediations of DNAm in the associations linking smoking and drinking with T2DM were found. In contrast, our study suggested a potential role of DNAm of cg19693031, cg00574958, and cg04816311 in mediating the effect of altered glycemic traits on T2DM.
TonEBP in myeloid cells promotes obesity-induced insulin resistance and inflammation through adipose tissue remodeling
Authors: Lee Hwan Hee , Jeong Gyu Won , Ye Byeong Jin , Yoo Eun Jin , Son Keoung Sun , Kim Dong Ki , Park Hye-Kyung , Kang Byoung Heon , Lee-Kwon Whaseon , Kwon Hyug Moo , Choi Soo Youn
Published: September 2022

The phenotypic and functional plasticity of adipose tissue macrophages during obesity play a crucial role in orchestration of adipose and systemic inflammation. Tonicity-responsive enhancer-binding protein (TonEBP, also called NFAT5) is a stress protein that mediates cellular responses to a range of metabolic insults. Here, we show that myeloid cell-specific TonEBP depletion reduced inflammation and insulin resistance in mice with high-fat diet-induced obesity, but did not affect adiposity. This phenotype was associated with a reduced accumulation and a reduced pro-inflammatory phenotype of metabolically activated macrophages; decreased expression of inflammatory factors related to insulin resistance; and enhanced insulin sensitivity. TonEBP expression was elevated in the adipose tissue macrophages of obese mice, and Sp1 was identified as a central regulator of TonEBP induction. TonEBP depletion in macrophages decreased induction of insulin resistance-related genes and promoted induction of insulin sensitivity-related genes under obesity-mimicking conditions, and thereby improved insulin signaling and glucose uptake in adipocytes. mRNA expression of TonEBP in peripheral blood mononuclear cells was positively correlated with blood glucose levels in mice and humans. These findings suggest that TonEBP in macrophages promotes obesity-associated systemic insulin resistance and inflammation, and downregulation of TonEBP may induce a healthy metabolic state during obesity. 
Activation of disulfide redox switch in REDD1 promotes oxidative stress under hyperglycemic conditions
Authors: Miller William P. , Sha Congzhou M. , Sunilkumar Siddharth , Toro Allyson L. , VanCleave Ashley M. , Kimball Scot R. , Dokholyan Nikolay V. , Dennis Michael D.
Published: September 2022

The stress response protein regulated in development and DNA damage response 1 (REDD1) has been implicated in visual deficits in diabetic patients. The aim here was to investigate the mechanism responsible for the increase in retinal REDD1 protein content that is observed with diabetes. We found that REDD1 protein expression was increased in the retina of streptozotocin-induced diabetic mice in the absence of a change in REDD1 mRNA abundance or ribosome association. Oral antioxidant supplementation reduced retinal oxidative stress and suppressed REDD1 protein expression in the retina of diabetic mice. In human retinal Müller cell cultures, hyperglycemic conditions increased oxidative stress, enhanced REDD1 expression, and inhibited REDD1 degradation independently of the proteasome. Hyperglycemic conditions promoted a redox-sensitive cross-strand disulfide bond in REDD1 at C150/C157 that was required for reduced REDD1 degradation. Discrete molecular dynamics simulations of REDD1 structure revealed allosteric regulation of a degron upon formation of the disulfide bond that disrupted lysosomal proteolysis of REDD1. REDD1 acetylation at K129 was required for REDD1 recognition by the cytosolic chaperone HSC70 and degradation by chaperone-mediated autophagy. Disruption of REDD1 allostery upon C150/C157 disulfide bond formation prevented the suppressive effect of hyperglycemic conditions on REDD1 degradation and reduced oxidative stress in cells exposed to hyperglycemic conditions. The results reveal redox regulation of REDD1 and demonstrate the role of a REDD1 disulfide switch in development of oxidative stress.
A RELAÇÃO ENTRE O TAMANHO DA PUNIÇÃO FISCAL, SUA EFETIVA APLICAÇÃO E O NÍVEL DE PLANEJAMENTO TRIBUTÁRIO DA FIRMA: UM ESTUDO BASEADO EM MÉTRICAS CONTÁBEIS, PARECERES JURÍDICOS E LISTAS DE DEVEDORES DO FISCO FEDERAL
Authors: Silva Wilton Sobrinho da
Published: September 2022

Este artigo investiga se há relação entre o tamanho da punição fiscal decorrente de atos que importem em redução de tributos e as tomadas de decisões de planejamento tributário agressivo nas empresas. O estudo apoiou-se nos ensinamentos anteriores legados pela Teoria da Agência, pela Teoria da Pena, e pelo framework do Planejamento Tributário. De uma amostra de 200 empresas listadas na B3 – S/A - Brasil, Bolsa, Balcão, buscou-se utilizar métricas contábeis como as provisões fiscais e os riscos de condenação fiscal efetiva, extraídos das condenações aplicadas efetivamente pelo Fisco Federal. Aplicada a técnica de regressão linear múltipla, com transformação de dados de Johnson, os resultados encontrados não puderam fundamentar a existência de associação entre o planejamento tributário agressivo e o tamanho da punição fiscal. Apurou-se que existe inter-relação entre as decisões de planejamento tributário agressivo e o nível de governança corporativa da firma e o setor de atuação das companhias.
UM ESTUDO DA ENTRADA EM INVALIDEZ NO REGIME PRÓPRIO DE PREVIDÊNCIA SOCIAL DO ESTADO DO CEARÁ
Authors: Rocha Alane Siqueira , De Pinho Breno Aloísio Torres Duarte , Cardoso Sérgio César de Paula , De Sousa Isaac Figueiredo , Fontoura Francisco Robson da Silva
Published: September 2022

Este artigo tem como objetivo estimar a probabilidade de entrada em aposentadoria por invalidez a partir da experiência do Regime Próprio de Previdência Social do estado do Ceará. Para isso, são utilizados dados provenientes de registrados administrativos, com o período de análise entre os anos de 2013 e 2017. As probabilidades de entrada em invalidez observadas foram suavizadas por meio de uma graduação não-paramétrica. A curva ajustada para as probabilidades de entrada em aposentadoria por invalidez se caracteriza por uma tendência de elevação das probabilidades, alcançando níveis mais altos por volta da idade de 64 anos, a partir da qual as probabilidades seguem uma trajetória de declínio. Os resultados foram comparados com tábuas de mercado. Entre as idades de 40 e 60 anos, observa-se uma aproximação entre as probabilidades de entrada em invalidez para o regime de previdência em estudo e as tábuas Grupo Americana e Álvaro Vindas.
GERENCIAMENTO DE RESULTADOS EM INSTITUIÇÕES FINANCEIRAS BRASILEIRAS: UMA REVISÃO DA LITERATURA RECENTE
Authors: Martiningo Filho Antônio , Durso Samuel de Oliveira
Published: September 2022

O objetivo deste artigo foi consolidar os principais estudos realizados nesse início de século sobre as práticas de gerenciamento de resultados nas instituições financeiras brasileiras. A partir dos procedimentos metodológicos adotados, foram revisadas e analisadas quinze pesquisas entre teses, dissertações e artigos. Como principal resultado, verificou-se que todos os estudos focaram a prática de gerenciamento de resultados tipificados na literatura como bad earnings management. As práticas de gerenciamento mais utilizadas, de acordo com as investigações analisadas, estão relacionadas com a constituição de Perdas Estimadas para Créditos de Liquidação Duvidosa (PECLD), Títulos e Valores Mobiliários (TVM) e derivativos. Entre as lacunas identificadas pela pesquisa destacam-se os possíveis impactos do IFRS 9 para a constituição da PECLD em instituições financeiras e a necessidade de estudos atuais sobre o impacto das estratégias de governança para as práticas de gerenciamento de resultados no setor.
A ECONOMIA TRIBUTÁRIA PROPORCIONADA PELA EXCLUSÃO DO ICMS DA BASE DE CÁLCULO DO PIS E COFINS DAS EMPRESAS TRIBUTADAS PELO LUCRO PRESUMIDO
Authors: Yuji Yoshitake Allan , Ferreira Erika Borges , De Aguiar Silva Renan , Guimarães Marques Thiago
Published: September 2022

O Recurso Extraordinário n°574.706 julgado pelo STF em março/17, considerou inconstitucional o ICMS na base de cálculo do PIS/COFINS. Após 4 anos, em 2021, a modulação determinou que a exclusão do ICMS se dá pelo valor destacado em nota fiscal, contrariando a Receita Federal que havia determinado, através da Solução de Consulta n°13, que o valor a ser excluído era o ICMS a recolher. Objetivando identificar o benefício financeiro, recalculou-se as contribuições de 2018 e projetou-se para os demais períodos, uma amostra de 40 empresas tributadas pelo lucro presumido. Adotou-se uma pesquisa aplicada e quantitativa, sem adoção de métodos estatísticos. Assim, as empresas objeto de estudo, possuem aproximadamente R$ 1,5 milhão e meio pago a maior, representando uma redução de 15,30% para as indústrias e 23,28% para o comércio. Essas discussões tributárias demonstram como o profissional contábil necessita de atualização em relação as modificações tributárias e fiscais.
Mevcut Rijitlik Denklemleri Kullanılarak Sonlu Elemanlarda Mafsal ve Elastik-Bağlantı Uygulaması Üzerine Pratik Bir Yaklaşım
Authors: YILMAZ Murat
Published: September 2022

The usefulness of Finite Element (FE) models for many engineering purposes depends on the element's ability to support a variety of end-connection types including releases and partial-fixities. However, adding such features to a FE model would require additional theoretical effort in the element development process. Alternatively, zero-length external connector-elements can be used in the mesh structure, but this will complicate both mesh definition and assemblage operations. This study shows that the existing stiffness equations of any FE model with regular rigid connections can be effectively employed to automatically define both end-releases and end-partial-fixities by simply applying a basic matrix-equation modification process without the need for any additional theoretical development on the element itself. Our process can be summarized in three basic steps. Firstly, element equations are separated from the system equation by defining element’s own degree-of-freedoms (DOFs). Secondly, elastic springs are introduced between the element and the system. Finally, the element is merged back into the system by eliminating its newly defined DOFs from the emerged equations. It has been verified by examples that, using these steps results in a new set of element equations with the desired end-releases/partial fixities and can be used in custom FE models.
Agrega Tane Boyut Dağılımı ve PP Lif Kullanımının Betonda Plastik Rötre Çatlağı Oluşumu Üzerine Etkileri
Authors: TÜRKMENOĞLU Hasan Nuri , ATAHAN Hakan Nuri
Published: September 2022

Plastik rötre betonun henüz sertleşmediği zaman diliminde meydana gelen yüzeysel bir çatlak türüdür. Temel nedeni beton yüzeyindeki buharlaşma hızının betonun terleme hızından yüksek olmasına bağlı olarak yüzeyin kurumasıdır. Böylece beton yüzeyi büzülmeye başlarken, alt kısımlarda kalan beton plastik kıvamda olduğu için yüzey ile benzer büzülmeyi gösteremez ve yüzeyde harita şeklinde çatlaklar oluşur. Yapılan çalışmada, toplam agrega hacminin sabit olduğu 3 farklı agrega dağılımına sahip beton ve 2 farklı polipropilen lif değişik oranlarda kullanılarak plastik rötre üzerine etkileri incelenmiştir. Deneylerde yöntem olarak ASTM C1579 standardı esas alınmış olup çatlak parametreleri deney sırasında çekilen fotoğraflar işlenerek elde edilmiştir. Elde edilen sonuçlar daha iri agrega dağılımının çatlak oluşumunu önlemede daha başarılı olduğunu ortaya koymuştur. Fakat çatlağı önlemek için kullanılan liflerin etkinliği agrega dağılımı irileştikçe azalmıştır. Diğer yandan kullanılan lifler plastik rötre çatlağını belirgin bir şekilde engellemişlerdir fakat aynı boydaki liflerden narinliği daha yüksek olan monofilament lifin kullanıldığı betonlardan daha iyi sonuçlar elde edilmiştir.
Factors Influencing Farmers’ Access to Formal Credit Market in Naogaon District of Bangladesh: An Empirical Analysis
Authors: Rahman Zubaidur , Islam Md. Johurul , Mahmuda Sayda , Hossain Dr. Md. Elias
Published: September 2022

Modern agriculture is expensive as performing agricultural activities nowadays requires huge investment. But some farmers do not have sufficient money to purchase and use such modern inputs like power tiller, harvester, deep-tube wells, fertilizers and pesticides in many cases. In Bangladesh, farmers are always found to face difficulties in access to credit services from both formal and informal service providers. As a result, their productivity and growth are impeded by a lack of access to agricultural loans. To investigate this phenomenon, this study aims to analyze the scenario of formal credit sources and to identify the factors that influence the access for farmers to formal credit market in Naogaon district. Primary data used for the study were collected with the aid of well-structured questionnaire from farmers and bank officials. Multi-stage sampling techniques were used to select the 200 respondents. The data were analyzed using descriptive statistics and a binary logistic regression model. The Likert scale was used to identify constraints regarding to credit acquisition from formal credit market. The results of the descriptive analysis showed that 6% farmers failed to repay their loan while 94% timely repay their loan. In terms of purpose of using agricultural credit, it is evident that 68% farmers use agricultural credit for managing their agricultural expenses while 17% respondents use loan for the purpose of paid their previous loan. In addition, 10% respondents use loans for the purpose of maintain their family expenses. Results found from the binary logit model indicate that farm size, education, farming experience, access to extension service, access to guarantor, own savings account are positively related with the log of odd ratio in favor of access to formal credit market while the same is influenced negatively by age, off-farm income and default on loan repayment. The farmers in the study area have recognized collateral security as the major constraint relating access to formal credit market followed by the lack of guarantor and bureaucratic complexity. It was recommended that the socioeconomic characteristics of farmers should be considered when formulating and implementing policies to improve farmers’ access to agricultural loans.
The Influence of Achievement Motivation and Nurse's Career Development on Continuous Professional Development with Nurses’ Beliefs About the Importance of Learning as a Mediation Variable at Bunda Margonda General Hospital
Authors: Saragih Ersida , Pamungkas Rian Adi , Rita Kemala
Published: September 2022

Nurses are the largest human resources in hospitals and have an important role in maintaining and improving the quality of health services in hospitals. The behavior of nurses in professional development is important to study because nurses are an integral part in patient care and play an important role in improving the quality of hospitals, so nurses have the responsibility to ensure patient safety with adequate competence. The competence of nurses must be maintained through the development of continuous professional development (CPD). The purpose of this study was to analyze the effect of achievement motivation and nurses' career development on behavior in professional development with nurses' beliefs about the importance of learning at Bunda Margonda General Hospital Research Methods: This research is a quantitative study with cross-sectional time dimensions with data analysis method using regression. The population in this study was 125 people. The results showed the effect of achievement motivation and nurses' career development on behavior in professional development with nurses' beliefs about the importance of learning at Bunda Margonda General Hospital with a P-value of 0.000. Suggestion: Create a nursing professional development program that refers to PMK No. 40 of 2017, seeking to provide a reward system according to the achievements of nurses, and socialize career development ways to employees.
Business Strategy for Oil Refinery Company in Facing Challenges in The Crude Oil Refining Industry
Authors: Setiadi Umar Heru , Dhewanto Wawan
Published: September 2022

The development of the energy industry in a developing country in Asia is undergoing a transition process from oil and gas energy to electrical energy and renewable energy. Based on Government data, the share of oil and gas will decrease from the current 32% to 20% in 2050, this is in line with the increase in penetration of electrification and other energy diversification. However, the demand for oil and gas will continue to increase significantly due to the increase in population. PTM, an energy company in a developing country, one of its refineries supplied 26% of domestic fuel demand by the end of 2021. The company is facing several challenges that affect its business, especially in one of its domestic oil refineries. Domestic crude production (upstream) is predicted to decline by up to 40% in the next 10 years so to meet the need for crude as raw material for refineries, it must be met through imports. Most of the imported crude is sour crude (high Sulfur), while the existing refinery is designed to process sweet crude (low Sulfur) which is more expensive than sour crude, so it will reduce the company's profit in the future. The demand for fuel and petrochemical products in the country is currently still high, where the country still imports 40% of fuel products and 40% of petrochemical products. Besides, the company is faced with the fact that Most refineries use old technology, Lower complexity than international competitors, and Lower conversion rate results in low profit. Therefore, the company requires a business strategy to face the above business challenges in order to generate better profits and become more competitive in the future. This study aims to find the appropriate business strategy for the company. This study uses VRIO Analysis and Business Model Canvas to determine the company's internal business environment, using PESTLE and Porter's Five Forces to determine the company's external business environment. Then summarized through SWOT Analysis and using a business strategy formulation through 3 stages: Stage 1 (Input) consisting of Internal Factor Evaluation (IFE) Matrix and External Factor Evaluation (EFE) matrix, stage 2 (Matching) consisting of SWOT Matrix and Internal-External (IE), Stage 3 (Decision) using Quantitative Strategic Planning Matrix (QSPM). Finally, the result of The Quantitative Strategic Planning Matrix (QSPM) is Market Development. Market Development is the appropriate strategy for the company and was chosen as the first priority strategy, namely increase crude processing capacity & flexibility, and upgrade refinery technology. With these strategies, the company is expected to be more competitive and generate better profits in the future.
The Effect of Remuneration, Employee Competency and Leadership Style on Civil Service Performance
Authors: Huda M. Miftahul , Sunardi  , Sumarsono Tanto G.
Published: September 2022

This research was conducted to determine the effect of remuneration, competition, leadership style on employee performance. This type of research is explanatory research with a quantitative approach. The data used in this study are primary data obtained by distributing questionnaires, interviews. The sampling method using a survey with a sample of 63 respondents. Data analysis in this study uses multiple linear regression methods with the help of SPSS 16. The results of this study indicate that remuneration has a significant effect on employee performance. Employee Competition has a significant effect on Employee Performance. Leadership Style has a significant effect on employee performance.