bluuebunny/crossref_metadata_2025 huggingface dataset:
Upregulation of Taurine Biosynthesis and Bile Acid Conjugation with Taurine through FXR in a Mouse Model with Human-like Bile Acid Composition
Authors: Miyazaki Teruo , Ueda Hajime , Ikegami Tadashi , Honda Akira
Published: July 2023

Taurine, the end product in the sulfur-containing amino acid pathway, is conjugated with bile acids (BAs) in the liver. The rate-limiting enzymes in both taurine synthesis and BA conjugation may be regulated by a nucleus receptor, FXR, that promotes BA homeostasis. However, it is controversial because BAs act as natural FXR agonists or antagonists in humans and mice, respectively, due to the species differences in BA synthesis. The present study evaluated the influences of different BA compositions on both pathways in the liver by comparing Cyp2a12−/−/Cyp2c70−/− mice with a human-like BA composition (DKO) and wild-type (WT) mice. The DKO liver contains abundant natural FXR agonistic BAs, and the taurine-conjugated BA proportion and the taurine concentration were significantly increased, while the total BA concentration was significantly decreased compared to those in the WT liver with natural FXR antagonistic BAs. The mRNA expression levels of the enzymes Bacs and Baat in BA aminations and Cdo and Fmo1 in the taurine synthesis, as well as Fxr and its target gene, Shp, were significantly higher in the DKO liver than in the WT liver. The present study, using a model with a human-like BA composition in the liver, confirmed, for the first time in mice, that both the taurine synthesis and BA amidation pathways are upregulated by FXR activation.
Exploring the Phytobeneficial and Biocontrol Capacities of Endophytic Bacteria Isolated from Hybrid Vanilla Pods
Authors: Lalanne-Tisné Guillaume , Barral Bastien , Taibi Ahmed , Coulibaly Zana Kpatolo , Burguet Pierre , Rasoarahona Felah , Quinton Loic , Meile Jean-Christophe , Boubakri Hasna , Kodja Hippolyte
Published: July 2023

In this study, 58 endophytic bacterial strains were isolated from pods of two hybrid vanilla plants from Madagascar, Manitra ampotony and Tsy taitra. They were genetically characterized and divided into four distinct phylotypes. Three were associated to genus Bacillus species, and the fourth to the genus Curtobacterium. A selection of twelve strains corresponding to the identified genetic diversity were tested in vitro for four phytobeneficial capacities: phosphate solubilisation, free nitrogen fixation, and phytohormone and siderophore production. They were also evaluated in vitro for their ability to biocontrol the growth of the vanilla pathogenic fungi, Fusarium oxysporum f. sp. radicis vanillae and Cholletotrichum orchidophilum. Three bacteria of phylotype 4, m62a, m64 and m65, showed a high nitrogen fixation capacity in vitro, similar to the Pseudomonas florescens F113 bacterium used as a control (phospate solubilizing efficiency respectively 0.50 ± 0.07, 0.43 ± 0.07 and 0.40 ± 0.06 against 0.48 ± 0.03). Strain t2 related to B. subtilis showed a higher siderophore production than F113 (respectively 1.40 ± 0.1 AU and 1.2 ± 0.1 AU). The strain m72, associated with phylotype 2, showed the highest rate of production of Indole-3-acetic acid (IAA) in vitro. Bacteria belonging to the pylotype 4 showed the best capacity to inhibit fungal growth, especially the strains m62b m64 and t24, which also induced a significant zone of inhibition, suggesting that they may be good candidates for controlling fungal diseases of vanilla. This competence was highlighted with spectral imaging showing the production of lipopeptides (Iturin A2 and A3, C16 and C15-Fengycin A and C14 and C15-Surfactin) by the bacterial strains m65 confronted with the pathogenic fungi of vanilla.
Comparative Genomic Analysis of Biofilm-Forming Polar Microbacterium sp. Strains PAMC22086 and PAMC21962 Isolated from Extreme Habitats
Authors: Kim Byeollee , Gurung Saru , Han So-Ra , Lee Jun-Hyuck , Oh Tae-Jin
Published: July 2023

The members of Microbacterium isolated from different environments are known to form peptidoglycan. In this study, we compared the biofilm-forming abilities of Microbacterium sp. PAMC22086 (PAMC22086), which was isolated from the soil in the South Shetland Islands and Microbacterium sp. PAMC21962 (PAMC21962), which was isolated from algae in the South Shetland Islands. The analysis of average nucleotide identity and phylogeny of PAMC22086 revealed a 97% similarity to Microbacterium oxydans VIU2A, while PAMC21962 showed a 99.1% similarity to Microbacterium hominis SGAir0570. For the comparative genomic analysis of PAMC22086 and PAMC21962, the genes related to biofilm formation were identified using EggNOG and KEGG pathway databases. The genes possessed by both PAMC22086 and PAMC21962 are cpdA, phnB, rhlC, and glgC, which regulate virulence, biofilm formation, and multicellular structure. Among the genes indirectly involved in biofilm formation, unlike PAMC21962, PAMC22086 possessed csrA, glgC, and glgB, which are responsible for attachment and glycogen biosynthesis. Additionally, in PAMC22086, additional functional genes rsmA, which is involved in mobility and polysaccharide production, and dksA, GTPase, and oxyR, which play roles in cell cycle and stress response, were identified. In addition, the biofilm-forming ability of the two isolates was examined in vivo using the standard crystal violet staining technique, and morphological differences in the biofilm were investigated. It is evident from the different distribution of biofilm-associated genes between the two strains that the bacteria can survive in different niches by employing distinct strategies. Both strains exhibit distinct morphologies. PAMC22086 forms a biofilm that attaches to the side, while PAMC21962 indicates growth starting from the center. The biofilm formation-related genes in Microbacterium are not well understood. However, it has been observed that Microbacterium species form biofilm regardless of the number of genes they possess. Through comparison between different Microbacterium species, it was revealed that specific core genes are involved in cell adhesion, which plays a crucial role in biofilm formation. This study provides a comprehensive profile of the Microbacterium genus’s genomic features and a preliminary understanding of biofilm in this genus, laying the foundation for further research.
Three-Dimensional Inversion of Long-Offset Transient Electromagnetic Method over Topography
Authors: Wang Xinyu , Cai Hongzhu , Liu Lichao , Revil André , Hu Xiangyun
Published: July 2023

The long-offset transient electromagnetic method (LOTEM) is widely employed in geophysical exploration, including environmental investigation, mineral exploration, and geothermal resource exploration. However, most interpretations of LOTEM data assume a flat Earth, and the commonly used one-dimensional (1D) interpretation encounters significant challenges in achieving reliable geological interpretations when topography is ignored. To address these challenges, this study presents an effective three-dimensional (3D) LOTEM inversion method. In this study, we discretize the simulation domain using unstructured tetrahedra to accurately simulate complex geological structures. The finite-element time-domain (FETD) method is utilized to calculate the LOTEM forward responses, and the limited-memory BFGS (L-BFGS) optimization method is employed for 3D LOTEM inversion. To avoid explicit calculation of sensitivity, we obtain the product of the transposed sensitivity matrix and the vector through adjoint forward modeling. Several synthetic models are used to verify the developed program, and the influence of topography on LOTEM inversion is examined. The numerical results demonstrate that topography can significantly impact the inversion result, potentially leading to incorrect geological interpretations. Finally, the developed inversion algorithm is applied to a realistic ore model from Voisey’s Bay, Labrador, Canada. The 3D inversion successfully reconstructs the spatial distribution of the ore body, further confirming the effectiveness of the developed algorithm.
Emerging Pathogen Threats in Transfusion Medicine: Improving Safety and Confidence with Pathogen Reduction Technologies
Authors: Cardoso Marcia , Ragan Izabela , Hartson Lindsay , Goodrich Raymond P.
Published: July 2023

Emerging infectious disease threats are becoming more frequent due to various social, political, and geographical pressures, including increased human–animal contact, global trade, transportation, and changing climate conditions. Since blood products for transfusion are derived from donated blood from the general population, emerging agents spread by blood contact or the transfusion of blood products are also a potential risk. Blood transfusions are essential in treating patients with anemia, blood loss, and other medical conditions. However, these lifesaving procedures can contribute to infectious disease transmission, particularly to vulnerable populations. New methods have been implemented on a global basis for the prevention of transfusion transmissions via plasma, platelets, and whole blood products. Implementing proactive pathogen reduction methods may reduce the likelihood of disease transmission via blood transfusions, even for newly emerging agents whose transmissibility and susceptibility are still being evaluated as they emerge. In this review, we consider the Mirasol PRT system for blood safety, which is based on a photochemical method involving riboflavin and UV light. We provide examples of how emerging threats, such as Ebola, SARS-CoV-2, hepatitis E, mpox and other agents, have been evaluated in real time regarding effectiveness of this method in reducing the likelihood of disease transmission via transfusions.
Early Introduction of Power Mobility Devices for Children with Fukuyama Congenital Muscular Dystrophy and Its Psychological Impact on Caregivers: A Case Report
Authors: Fujita Hitomi
Published: July 2023

Recently, motorized mobility devices (or power mobility devices (PMDs)) have been introduced for infants and toddlers who lack the means for self-mobility. Previous reports have primarily focused on PMDs for individuals with cerebral palsy. Few have explored PMDs for individuals with neuromuscular diseases who have intellectual disabilities. This report presents a case study of the early introduction of a PMD for an infant with Fukuyama congenital muscular dystrophy and presents the results of an interview with the father regarding psychological aspects and the child’s manipulative abilities. The PMD was introduced at the age of 1 year and 10 months, and the changes during the 19 months after the introduction were evaluated six times, using the Assessment of Learning Powered mobility use tool (ALP). A semi-structured interview with the father was conducted 19 months after the introduction. The ALP evaluation and the interview were conducted by one physical therapist and two physical therapy students, and the results were shared with the hospital’s physical therapist and nurses at the nursing facility. This report provides a basis for expanding the scope of PMD use and for considering the family’s involvement, especially for the child.
The Design of Large Curved Waveguide Based on Sunflower Graded Photonic Crystal
Authors: Liu Wei , Liu Hechao , Sun Xiaohong , Zhang Fan
Published: July 2023

In this paper, three large curved waveguides based on Sunflower Graded photonic crystal are designed. Numerical simulations of electromagnetic beam bending in Sunflower Graded photonic crystals have shown that homogenization based on the Maxwell–Garnett theory gives very good results for steering the electromagnetic field. In contrast to the progressive bending waveguide structures based on periodic photonic crystal designs reported in the literature, this structure is not only simple in design, but also the optical wave trends in the progressive bending waveguide structures are more smooth. Sunflower structures, due to their high circular symmetry, have a great advantage in making arbitrary curved waveguides. The results have some theoretical implications for the design of optical integrated circuits and the selection of optically thin communication devices. It is also useful for the selection of meta-materials.
Extinction and Independent Scattering Criterion for Clusters of Spherical Particles Embedded in Absorbing Host Media
Authors: Zhai Jinan , Zhang Shangyu , Liu Linhua
Published: July 2023

In practical applications, the independent scattering approximation (ISA) is widely used to analyze light transfer in nanoparticle systems. However, the traditional independent scattering criterion is obtained under the assumption that the host medium surrounding particles is nonabsorbing, and thus may be invalid in certain circumstances. In this work, to explore the applicability of the ISA for small particles in absorbing host media, we calculate the extinction efficiency of particle clusters by direct solutions of macroscopic Maxwell equations. Using the far-field and distance-independent definitions of extinction, the computational efficiency multi-sphere method is applied for particle clusters in absorbing host, and its accuracy is verified with the discrete dipole approximation method. It is well known that for small particles, the dependent scattering in transparent host always enhances the extinction of the cluster and the criterion for the ISA is nearly independent of the particle refractive index and particle size. We show, however, that when the host medium is absorbing, the dependent scattering between particles can lead to a decreased or even negative extinction, and thus the ISA criterion depends on the particle refractive index, size, and host medium absorption index. In this result, the generalized criteria for absorbing host media may differ significantly from the conventional ones for transparent host media. The results can provide guidance in solving problems related to light transfer in nanoparticle systems, particularly in the presence of absorption in the host medium.
Lacustrine Shale Diagenesis—A Case Study of the Second Member of the Funing Formation in the Subei Basin
Authors: Wang Shuping , Ma Cunfei , Sun Xue , Liu Shili
Published: July 2023

Shale diagenesis differs from that of sandstone and carbonate rocks with regard to the type, evolution stage, and evolution mode. The quality of shale reservoirs is closely linked to the extent of diagenetic evolution. This study identifies the types and characteristics of shale diagenesis using thin sections and scanning electron microscopy (SEM) observations. The stages of shale diagenesis are determined by analyzing organic matter evolution and clay mineral transformation and establishing a diagenetic evolution sequence. This paper describes the comprehensive diagenetic evolution of organic matter, clay minerals, clastic particles, and carbonate minerals to determine the diagenesis types, diagenetic sequences, and pore evolution occurring during diagenetic evolution. The results show that the diagenesis types of shale in the second member of the Funing Formation include compaction, dissolution, cementation, metasomatism, dolomitization, syneresis, and transformation of clay minerals, as well as thermal evolution of organic matter. The middle diagenetic A stage is prevalent, with some areas in the early and middle diagenetic B stages. The shale underwent a diagenetic evolution sequence, including the collapse and shrinkage of montmorillonite interlayers in the early stage; the rapid formation and transformation of illite and smectite mixed layers, massive hydrocarbon generation of organic matters, and dissolution of unstable components in the middle stage; and the occurrence of fractures filled with gypsum, quartz, ferrocalcite, or other authigenic minerals in the later stage. Dissolution pores and fractures are the dominant shale reservoirs of the second member of the Funing Formation in the Subei Basin. The results provide new insights into understanding the formation and evolution of reservoir spaces during shale diagenesis and information for the exploration and development of lacustrine shale oil and gas.
Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields
Authors: Casarin Martina , Todesco Martina , Fontanella Chiara Giulia , Morlacco Alessandro , Dal Moro Fabrizio , Bagno Andrea
Published: July 2023

The main purpose of tissue engineering is to fabricate and exploit engineered constructs suitable for the effective replacement of damaged tissues and organs to perfectly integrate with the host’s organism without eliciting any adverse reaction. Ideally, autologous materials represent the best option, but they are often limited due to the low availability of compatible healthy tissues. So far, one therapeutic approach relies on the exploitation of synthetic materials as they exhibit good features in terms of impermeability, deformability, and flexibility, but present chronic risks of infections and inflammations. Alternatively, biological materials, including naturally derived ones and acellular tissue matrices of human or animal origin, can be used to induce cells growth and differentiation, which are needed for tissue regeneration; however, this kind of material lacks satisfactory mechanical resistance and reproducibility, affecting their clinical application. In order to overcome the above-mentioned limitations, hybrid materials, which can be obtained by coupling synthetic polymers and biological materials, have been investigated with the aim to improve biological compatibility and mechanical features. Currently, the interest in these materials is growing, but the ideal ones have not been found yet. The present review aims at exploring some applications of hybrid materials, with particular mention to urological and cardiovascular fields. In the first case, the efforts to find a construct that can guarantee impermeability, mechanical resistance, and patency is herein illustrated; in the second case, the search for impermeability, hemocompatibility and adequate compliance is disclosed.
Comparison of Two Lab Simulation Methods of Multiple Heavy Metal Contamination on FCC Catalysts
Authors: Yang Yong , Zu Zixuan , Ma Xueli , Liu Chaowei , Su Yi , Li Hongwei , Ji Dong
Published: July 2023

Qualitative and quantitative description are key to solving the problem of heavy metal contamination on fluid catalytic cracking (FCC) catalysts. The loading efficiencies for different metals were compared for the two lab simulation methods of Multi-Cyclic Deactivation (MCD) and Advanced Catalyst Evaluation (ACE), and the microcatalytic performance of metal-contaminated catalysts was evaluated using an ACE Model C device. The results show that the MCD and ACE methods both obtain extremely high data accuracy, indicating that they can be used to ensure the parallel reliability of experimental results. The typical operating parameters for hydrothermal aging and metals loading can be adjusted to suit different metal types and content targets for either of these two simulation methods. Compared with an equilibrium catalyst from an industrial unit, the MCD method has the advantages of basic hydrothermal aging treatment with less metal loading efficiency, while the ACE method has an accurate metal amount and high loading efficiency for metal contamination, with a metal balance recovery rate above 99.5% at similar activation to the equilibrium catalyst. When used with a reasonable and effective metal pretreatment scheme, these two laboratory simulation methods can be used to evaluate new commercial catalysts and in fundamental experiments for the improvement of FCC catalysts for removal of metal contamination.
Bridging the Gap between Dermatology and Psychiatry: Prevalence and Treatment of Excoriation Disorders Secondary to Neuropsychiatric Medications
Authors: Thompson Brittany M. , Brady Joshua M. , McBride Jeffrey D.
Published: July 2023

(1) Background: The dermatillomania and trichotillomania disorders in this study refer to the subcategory of obsessive-compulsive disorders (OCDs) that are medication-induced. Patients with typical dermatillomania or trichotillomania disorder generally present with other OCD symptoms, although this is not present in the cases of medication-induced skin picking or hair pulling disorders found in the current literature. This paper serves to investigate the prevalence and treatment methods of medication-induced excoriation disorders. (2) Methods: The PubMed database was queried for cases of medication-induced dermatillomania or trichotillomania. The database search resulted in 80 results, 7 of which were full-length case reports in English with acceptable detail on clinical course, yielding nine patients. (3) Results: All patients who discontinued their offending agent had complete resolution of symptoms. Patients who continued their medications saw a resolution of symptoms when treated with an additional medication. Atypical antipsychotics and SSRIs were also noted to have been the offending agent in some cases but a successful treatment in other cases. (4) Conclusion: Patients who discontinued their offending agent or added additional pharmacotherapy for dermatillomania or trichotillomania had the best outcomes. Abnormal serotonin and dopamine levels are thought to be connected to the pathology of this disease.
Magnetic Susceptibility Prospecting and Geochemical Characterization of Taxco’s Mining Waste Dam Guerrero I (Mexico)
Authors: Morales Juan , Hernández Bernal María del Sol , Pérez Rodríguez Nayeli , Goguitchaichvili Avto
Published: July 2023

Mining activity at Taxco produces seven mining waste deposits, which are problematic for the health of the community and for the environment in general. This study targets the Guerrero I mining waste dam (the youngest of the region), located south of Taxco de Alarcon, in the northern portion of Guerrero State, Mexico. This study reports the vertical magnetic susceptibility prospecting results and geochemical characterization of 27 tailing samples from the Guerrero I dam. Results from magnetic techniques provide evidence for different deposit layers of variable mineral composition, in agreement with the lithological column. The short evolution period of this relatively young dam is corroborated by the practically constant and close to 1 S-300 ratio (low oxidation degree of the magnetic mineralogy) and the mainly neutral pH character at the dam’s upper part. Most maximum concentrations of potentially toxic elements are below the maximum permissible levels for agriculture/residential use, except for those of Pb and Zn, with average enrichment factors above 90 and 50 times the corresponding regional background concentrations, respectively. Simple sample preparation and fast magnetic and X-ray fluorescence elemental concentration measurements, together with a suitable systematic sampling distribution, result in an advantageous proxy method for a quick and cost-effective heavy metal evaluation of mining waste dams.
Broadcast Propagation Time in SpaceFibre Networks with Various Types of Spatial Redundancy
Authors: Olenev Valentin , Suvorova Elena , Chumakova Nadezhda
Published: July 2023

Various methods of spatial redundancy can be used in local networks based on the SpaceFibre standard for fault mitigation of network hardware and physical communication channels. Usually, a network developer chooses the method of spatial redundancy according to the number of failures that have to be mitigated, the time required for restoring the normal operation of the network, required overheads and hardware costs. The use of different spatial redundancy mechanisms can cause changes in the structure of the links between network nodes, in case of failure and subsequent mitigation. In turn, this may cause changes in the broadcast transmission paths and the temporal characteristics of their delivery from the source to the receivers. This article focuses on the change in the propagation time of broadcasts in SpaceFibre networks with spatial redundancy. Broadcast propagation rules significantly differ from data-packet propagation rules. Broadcast distribution time is very important for many applications, because broadcasts are generally used to send urgent messages, in particular for time synchronization. Various formal methods have been used to evaluate the propagation characteristics of the broadcast. A method for estimating broadcast propagation time along the shortest routes is proposed. In addition, we provide a formal method to estimate the number of failures, which occurred in the network during the broadcast propagation. This method is based on timed Petri nets; one of its features is the ability to calculate broadcast transmission delays. In addition, as an alternative solution, we propose a method for estimating delays based on time automata theory.
Magnetic Properties of FeNi/Cu-Based Lithographic Rectangular Multilayered Elements for Magnetoimpedance Applications
Authors: Melnikov Grigory Yu. , Vazhenina Irina G. , Iskhakov Rauf S. , Boev Nikita M. , Komogortsev Sergey V. , Svalov Andrey V. , Kurlyandskaya Galina V.
Published: July 2023

The rectangular elements in magnetoimpedance (MI) configuration with a specific nanocomposite laminated structure based on FeNi and Cu layers were prepared by lift-off lithographic process. The properties of such elements are controlled by their shape, the anisotropy induced during the deposition, and by effects associated with the composite structure. The characterizations of static and dynamic properties, including MI measurements, show that these elements are promising for sensor applications. We have shown that competition between the shape anisotropy and the in-plane induced anisotropy of the element material is worth taking into account in order to understand the magnetic behavior of multilayered rectangular stripes. A possibility of the dynamic methods (ferromagnetic and spin-wave resonance) to describe laminated planar elements having a non-periodic modulation of both structure and magnetic parameters of a system is demonstrated. We show that the multilayered structure, which was originally designed to prevent the development of a “transcritical” state in magnetic layers and to reach the required thickness, also induces the effects that hinder the achievement of the goal, namely an increase in the perpendicular magnetic anisotropy energy.
Design of Miniature Ultrawideband Active Magnetic Field Probe Using Integrated Design Idea
Authors: Zhou Yang , Yan Zhaowen , Ma Zhangqiang , Zhao Yang , Gao Jie , Cheng Ruiqi , Huang Baocheng
Published: July 2023

This article presents a miniature ultrawideband active magnetic probe which is composed of a passive structure and an active amplification circuit structure. The active circuit mainly contains two chips, specifically an amplification chip (HMC797APM5E) and a power management chip (HMC980LP4E). The maximum size of the probe is no more than 64 × 41.5 mm2. Compared with the passive probe with the same-sized loop, the sensitivity of the proposed probe is enhanced by 25 dB through the active circuit design. The working frequency bandwidth of the proposed probe can cover 9 kHz to 18 GHz. Additionally, the flatness is about ±4 dB in terms of |S21| in the stable working bandwidth. It is efficient for high-frequency near-field scanning.
Using Feature Engineering and Principal Component Analysis for Monitoring Spindle Speed Change Based on Kullback–Leibler Divergence with a Gaussian Mixture Model
Authors: Huang Yi-Cheng , Hou Ching-Chen
Published: July 2023

Machining is a crucial constituent of the manufacturing industry, which has begun to transition from precision machinery to smart machinery. Particularly, the introduction of artificial intelligence into computer numerically controlled (CNC) machine tools will enable machine tools to self-diagnose during operation, improving the quality of finished products. In this study, feature engineering and principal component analysis were combined with the online and real-time Gaussian mixture model (GMM) based on the Kullback–Leibler divergence’s measure to achieve the real-time monitoring of changes in manufacturing parameters. Based on the attached accelerometer device’s vibration signals and current sensing of the spindle, the developed GMM unsupervised learning was successfully used to diagnose the spindle speed changes of a CNC machine tool during milling. The F1-scores with improved experimental results for X, Y, and Z axes were 0.95, 0.88, and 0.93, respectively. The established FE-PCA-GMM/KLD method can be applied to issue warnings when it predicts a change in the manufacturing process parameter. A smart sensing device for diagnosing the machining status can be fabricated for implementation. The effectiveness of the developed method for determining the manufacturing parameter changes was successfully verified by experiments.
Evaluation of 5G and Fixed-Satellite Service Earth Station (FSS-ES) Downlink Interference Based on Artificial Neural Network Learning Models (ANN-LMS)
Authors: Al-Jumaily Abdulmajeed , Sali Aduwati , Jiménez Víctor P. Gil , Lagunas Eva , Natrah Fatin Mohd Ikhsan , Fontán Fernando Pérez , Hussein Yaseein Soubhi , Singh Mandeep Jit , Samat Fazdliana , Aljumaily Harith , Al-Jumeily Dhiya
Published: July 2023

Fifth-generation (5G) networks have been deployed alongside fourth-generation networks in high-traffic areas. The most recent 5G mobile communication access technology includes mmWave and sub-6 GHz C-bands. However, 5G signals possibly interfere with existing radio systems because they are using adjacent and co-channel frequencies. Therefore, the minimisation of the interference of 5G with other signals already deployed for other services, such as fixed-satellite service Earth stations (FSS-Ess), is urgently needed. The novelty of this paper is that it addresses issues using measurements from 5G base stations (5G-BS) and FSS-ES, simulation analysis, and prediction modelling based on artificial neural network learning models (ANN-LMs). The ANN-LMs models are used to classify interference events into two classes, namely, adjacent and co-channel interference. In particular, ANN-LMs incorporating the radial basis function neural network (RBFNN) and general regression neural network (GRNN) are implemented. Numerical results considering real measurements carried out in Malaysia show that RBFNN evidences better accuracy with respect to its GRNN counterpart. The outcomes of this work can be exploited in the future as a baseline for coexistence and/or mitigation techniques.
Enhancement of Refractive Index Sensitivity Using Small Footprint S-Shaped Double-Spiral Resonators for Biosensing
Authors: Igarashi Anh , Abe Maho , Kuroiwa Shigeki , Ohashi Keishi , Yamada Hirohito
Published: July 2023

We demonstrate an S-shaped double-spiral microresonator (DSR) for detecting small volumes of analytes, such as liquids or gases, penetrating a microfluidic channel. Optical-ring resonators have been applied as label-free and high-sensitivity biosensors by using an evanescent field for sensing the refractive index of analytes. Enlarging the ring resonator size is a solution for amplifying the interactions between the evanescent field and biomolecules to obtain a higher refractive index sensitivity of the attached analytes. However, it requires a large platform of a hundred square millimeters, and 99% of the cavity area would not involve evanescent field sensing. In this report, we demonstrate the novel design of a Si-based S-shaped double-spiral resonator on a silicon-on-insulator substrate for which the cavity size was 41.6 µm × 88.4 µm. The proposed resonator footprint was reduced by 680 times compared to a microring resonator with the same cavity area. The fabricated resonator exposed more sensitive optical characteristics for refractive index biosensing thanks to the enhanced contact interface by a long cavity length of DSR structures. High quality factors of 1.8 × 104 were demonstrated for 1.2 mm length DSR structures, which were more than two times higher than the quality factors of microring resonators. A bulk sensitivity of 1410 nm/RIU was calculated for detecting 1 µL IPA solutions inside a 200 µm wide microchannel by using the DSR cavity, which had more than a 10-fold higher sensitivity than the sensitivity of the microring resonators. A DSR device was also used for the detection of 100 ppm acetone gas inside a closed bottle.
Beyond Frequency Band Constraints in EEG Analysis: The Role of the Mode Decomposition in Pushing the Boundaries
Authors: Arrufat-Pié Eduardo , Estévez-Báez Mario , Estévez-Carreras José Mario , Leisman Gerry , Machado Calixto , Beltrán-León Carlos
Published: July 2023

This study investigates the use of empirical mode decomposition (EMD) to extract intrinsic mode functions (IMFs) for the spectral analysis of EEG signals in healthy individuals and its possible biological interpretations. Unlike traditional EEG analysis, this approach does not require the establishment of arbitrary band limits. The study uses a multivariate EMD algorithm (APIT-MEMD) to extract IMFs from the EEG signals of 34 healthy volunteers. The first six IMFs are analyzed using two different methods, based on FFT and HHT, and the results compared using the ANOVA test and the Bland–Altman method for agreement test. The outcomes show that the frequency values of the first six IMFs fall within the range of classic EEG bands (1.72–52.4 Hz). Although there was a lack of agreement in the mean weighted frequency values of the first three IMFs between the two methods (>3 Hz), both methods showed similar results for power spectral density (<5% normalized units, %, of power spectral density). The HHT method is found to have better frequency resolution than APIT-MEMD associated with FTT that produce less overlapping between IMF3 and 4 (p = 0.0046) and it is recommended for analyzing the spectral properties of IMFs. The study concludes that the HHT method could help to avoid the assumption of strict frequency band limits, and that the potential impact of EEG physiological phenomenon on mode-mixing interpretation, particularly for the alpha and theta ranges, must be considered in future research.
On the RE2TiAl3 (RE = Y, Gd–Tm, Lu) Series—The First Aluminum Representatives of the Rhombohedral Mg2Ni3Si Type Structure
Authors: Gießelmann Elias C. J. , Engel Stefan , El Saudi Israa M. , Schumacher Lars , Radzieowski Mathis , Gerdes Josef Maximilian , Janka Oliver
Published: July 2023

Several ternary rare-earth metals containing titanium aluminum intermetallics in the RE2TiAl3 series (RE = Y, Gd–Lu) have been synthesized from the elements using arc-melting techniques. All compounds crystallize in the trigonal crystal system with rhombohedral space group R3m (Z = 3) and lattice parameters ranging between a = 582–570 and c = 1353–1358 pm. They adopt the Mg2Ni3Si-type structure, which is an ordered superstructure of the cubic Laves phase MgCu2 and has been observed for Al intermetallics for the first time. Tetrahedral [TiAl3] entities that are connected over all corners form a network where the empty [TiAl3] tetrahedra exhibit a full Ti/Al ordering based on the single crystal results. The Al atoms are arranged into 63 Kagomé nets, while the Ti atoms connect these nets over the triangular units. In the cavities of this three-dimensional arrangement, the RE cations can be found forming a distorted diamond-type substructure. Magnetic measurements revealed that Y2TiAl3 and Lu2TiAl3 are Pauli paramagnetic substances, in line with the metallic character. The other compounds exhibit paramagnetism with antiferromagnetic ordering at a maximum Néel temperature of TN = 26.1(1) K for Gd2TiAl3.
Star Excursion Balance Test as a Predictor of Musculoskeletal Injury and Lower Back Pain in Non-Professional Soccer Players
Authors: Sklempe Kokic Iva , Petric Katarina , Kuna Danijela , Jelica Stjepan , Kokic Tomislav
Published: July 2023

Soccer is a sport with worldwide popularity but has a substantial risk of injury. Clinical screening tools are an important factor in strategies of injury prevention. The purpose of the study was to examine the relationship between the Star Excursion Balance Test (SEBT) and injury and lower back pain (LBP) in amateur soccer players. The research was performed as a longitudinal cohort study on 42 amateur male soccer players with 15.8 ± 6.6 years of soccer playing (age: 25.5 ± 6 years). Participants were surveyed with regard to their soccer playing, injuries, and LBP, and the SEBT was performed. They were followed for 3.5 months. At the follow-up, an additional set of data regarding injuries and LBP was gathered. Significant differences were found in all directions and in the composite score of the SEBT between uninjured and injured players. Shorter distance in all directions and a lower composite score were associated with injury in general. Shorter distances in all but the anterior direction and a lower composite score were associated with lower extremity injury, and shorter anterior distance was associated with LBP. Amateur soccer players with lower SEBT scores are more prone to injuries in general, as well as injuries of the lower extremities. SEBT presents as a useful clinical screening tool in identifying amateur soccer players at risk of injury.
Factors Influencing Continuance Intention of Time-Sharing Cars
Authors: Huang Huiping , Nan Ganlin
Published: July 2023

Time-sharing cars, as a sustainable model for transport, have seen rapid developments in recent years. Prior studies on car sharing paid little attention to the continuance intention among users. But understanding ways to cultivate user habits is important to enhance car sharing’s contribution to sustainability. Based on the expectation confirmation model (ECM), this study adopts a user-centered perspective to explore factors affecting the continuance intention of time-sharing electric vehicles through personal cognitive variables (i.e., psychological ownership, familiarity, and trust) and external environmental variables (i.e., facilitating conditions and service quality). An online survey was conducted, and a total of 1072 valid samples were collected. The results of the structural equation modeling show that offline service quality and facilitating conditions had the greatest impact on the perceptions of usefulness and satisfaction users have for car sharing. Perceived usefulness and satisfaction positively predicted continuance intention, as in the ECM. Among customer variables, environmentalism, familiarity, and trust in peers positively predicted the perceived usefulness of car sharing. Psychological ownership played a subtle function by negatively affecting perceived usefulness but positively affecting satisfaction. We discuss the findings and practical implications for stakeholders and offer suggestions for future research.
Evaluating the Spatial and Temporal Characteristics of Summer Urban Overheating through Weather Types in the Attica Region, Greece
Authors: Petrou Ilias , Kyriazis Nikolaos , Kassomenos Pavlos
Published: July 2023

In this study, we investigated the association between weather type (WT) and urban heat island intensity (UHII) in the region of Attica (Greece). The application of the methodology resulted in ten WTs over the Attica region. The UHII was calculated for every hour of the day from 2008 to 2017, using a new air temperature dataset produced by Copernicus Climate Change Service. To obtain more definitive findings about the relationship between WTs and UHII, we also used the upper 5% of UHII (urban overheating, UO). UO was estimated for two time intervals (daytime and nighttime) and for the warm period (June–September). The UHII frequency distribution, as well as the spatiotemporal characteristics of the UO, were also investigated. It was found that UO was amplified under WT2 during the night, while WT10 was mainly related to increased UO magnitudes in the daytime in all months. Furthermore, analysis results revealed that the UO effect is more pronounced in Athens during the night, especially at the Athens center. The daytime hot spots identified were mainly in suburban and rural areas. Therefore, this methodology may help with heat mitigation strategies and climate adaptation measures in urban environments.
Pulsed Radiofrequency as a Standalone Treatment for Adhesive Capsulitis
Authors: Bongiorno Giulia , Bednarova Rym , Biancuzzi Helena , Dal Mas Francesca , Rizzardo Alessandro , Tomasi Andrea , Vigni Giulio Edoardo , Miceli Luca
Published: July 2023

Adhesive capsulitis is a pathology that affects the shoulder and can have a particularly long and disabling course. The usual therapies are treatment with non-steroidal anti-inflammatory drugs (NSAID) and painkillers, steroid injections, physiotherapy, and surgical treatment. This case report describes the effect of a single treatment with pulsed radiofrequency of the suprascapular nerve in a diabetic patient affected by this pathology, for whom steroid injections were contraindicated. Three weeks after the treatment, the reduction of pain and the improvement of ROM (range of movement) allowed the patient to start an adequate physiotherapy treatment, which was not feasible until that moment due to the severe pain despite NSAIDS therapy. The peculiarity of this work consists in the accurate measure of the impact of the analgesic treatment alone in improving the ROM and muscular activation in the patient. The patient was able to correctly perform physiotherapy only once the pain was reduced, after PRF (pulsed radio frequency) treatment. This study has two limitations: being a case report and not a prospective randomized study, and observing the kinematic and pain aspects for a limited period of time. Finally, the case report draws attention to the importance of cooperation between the various health figures involved in the treatment of patients suffering from adhesive capsules.
Digital Transformation and Corporate Sustainability: The Moderating Effect of Ambidextrous Innovation
Authors: Ying Ying , Jin Shanyue
Published: July 2023

Digital transformation (DT) has become the new normal. Research has focused on the effect of the overall level of DT in enterprises. However, the effects of DT across different dimensions remain unclear. This study divided DT into technology- (TDT) and market-based digital transformation (MDT). It examined the effects on corporate sustainability and how ambidextrous innovation affects the relationship between both types and corporate sustainability. This study used the two-way fixed-effects model and the two-stage least squares method to study A-share listed companies in China from 2013 to 2021. The results showed that both TDT and MDT had positive effects on corporate sustainability. The higher the levels of exploratory and exploitative innovation in enterprises, the stronger the contribution of both types of DT to corporate sustainability. The findings validate the research on DT in line with the resource-based view, enrich the literature on and expand the boundary conditions of DT applications across various dimensions, and offer useful insights for practitioners.
Off-Label Use of Crisdesalazine (GedaCure) in Meningoencephalitis in Two Dogs
Authors: Lee Saeyoung , Song Woo-Jin , Park Jongjin , Kim Minkun , Choen Sangkyung , Kim Myung-Chul , Jeong Hyohoon , Yun Youngmin
Published: July 2023

An 8-year-old, castrated male Shih-tzu dog (Case 1) showing ataxia and gait disorder was referred for neurological examination and magnetic resonance imaging. Through comprehensive examinations, the patient was tentatively diagnosed with meningoencephalitis of unknown origin (MUO) and treatment with prednisolone and cytosine arabinoside was started. The symptoms were improving with immunosuppressive treatment. However, severe bacterial cystitis occurred and we could not avoid tapering off prednisolone. Then, neurological signs recurred. Therefore, we added crisdesalazine, which allowed us to reduce the daily dosage of immunosuppressants easily. In another case, a 4-year-old, spayed female Yorkshire terrier dog (Case 2) was referred to our hospital showing a head tilt, circling, and loss of the menace reflex. The patient was tentatively diagnosed with MUO and treatment with some immunosuppressants was attempted. The clinical symptoms improved, but the alleviation was inadequate. Thus, we added crisdesalazine. The neurological signs then markedly improved. Moreover, the drugs could be tapered off more easily than before. Crisdesalazine is a novel drug that has antioxidant and anti-inflammatory action in brain disease and is used particularly for dementia. In this paper, we tried an off-label use of this drug in canine MUO patients, and found that it had, in these two patients, additional therapeutic effects on the MUO.
First Evidence of Familial Transmission of Hereditary Gastrointestinal Polyposis Associated with Germline APC Variant in Jack Russell Terriers
Authors: Yoneji Wakana , Yoshizaki Kyoko , Hirota Teruaki , Yoneji Kensuke , Yoshikawa Ryutaro , Mori Takashi , Sakai Hiroki , Hirata Akihiro
Published: July 2023

Jack Russell terriers (JRTs) with gastrointestinal (GI) neoplastic polyps have been recently reported to harbor an identical germline variant in the adenomatous polyposis coli (APC) gene, c.[462_463delinsTT], in the heterozygous state, which indicates that this disease is an autosomal dominant hereditary disorder. Many individual cases of this disease have been observed in clinical practice; however, familial transmission has not been demonstrated due to the difficulty in tracing the family members of household dogs, especially after the disease’s onset in adulthood. Recently, we encountered two cases of GI polyposis in maternal half sisters. These two cases facilitated the identification of additional relatives spanning three generations, including parents, full and half siblings of the dam (aunt and uncle), littermate and non-littermate siblings, and a nephew. Genetic analysis revealed that 11 of the 14 examined JRTs in this family carried the heterozygous germline APC variant, and eight dogs with the variant already had a current and/or past medical history of GI neoplastic polyps. Some cases in the family showed significantly more severe disease phenotypes than those initially reported, suggesting that the severity of this disease can vary considerably among individuals. Moreover, familial aggregation of severe cases suggested that the genetic modifier involved in increasing severity may have been transmitted in this family in addition to the germline APC variant. Furthermore, in addition to this family, we reported two other families of JRTs affected by hereditary GI polyposis that consisted of five full and half siblings and a mother–daughter pair, respectively. These findings unequivocally establish the transgenerational transmission of hereditary GI polyposis associated with the germline APC variant in JRT lineages.
Conclusion of an employment contract: some problems
Authors:   Department of Civil Procedure and International Law, Kuban State University, Krasnodar, Sokolenko N.N.
Published: July 2023

In modern conditions, a labor contract is a form of individual labor regulation that allows you to across-the-board assess the personal abilities of an employee, personalize his labor duties, individualize, specify working conditions, including the employer’s ability to establish benefits and guarantees, in addition to those established by law. However, the analysis of law enforcement and judicial practice of concluding an employment contract allows us to talk about some problems of legal regulation that need to be solved.