bluuebunny/crossref_metadata_2025 huggingface dataset:
Šedá vodní stopa jako ukazatel udržitelného vypouštění odpadních vod – případová studie Povodí Ohře
Authors: Ansorge Libor , Stejskalová Lada , Dlabal Jiří , Kučera Jiří
Published: January 2020

Cíle udržitelného rozvoje OSN požadují mimo jiné i zlepšit kvalitu vody snížením jejího znečišťování, zamezením vyhazování odpadů do vody a minimalizací vypouštění nebezpečných chemických látek do vody. Jedním z nástrojů, který lze využít pro posouzení udržitelnosti vypouštění znečištění do vod je vodní stopa. V článku je popsána analýza šedé vodní stopy velkých komunálních čistíren v povodí Ohře. Pro analýzu byly vybrány komunální čistírny odpadních vod uvedené státním podnikem Povodí Ohře ve zprávách vodohospodářské bilance. Byla stanovena asimilační kapacita toku pro jednotlivé znečišťující látky hlášené provozovateli čistíren odpadních vod pro účely vodohospodářské bilance, spočtena šedá vodní stopa látek vstupujících na čistírnu odpadních vod (produkované znečištění) a vypouštěných do recipientů v odpadní vodě. Posouzení udržitelnosti bylo provedeno k dlouhodobému průměrnému průtoku recipientem. Analýza ukázala, že asimilační kapacita vodních toků je nejvíce vytěžována vypouštěním celkového fosforu a amoniakálního dusíku. Zároveň z analýzy vyplynulo, že čistírny odpadních vod, až na výjimky, čistí vodu dostatečně a asimilační kapacita vodního toku nebývá vyčerpána.
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The Sustainable Development Goals (SDGs), adopted by all United Nations Member States in 2015, call, among others, for the improvement of water quality by reducing water pollution, avoiding waste disposal in water and minimizing hazardous chemicals discharge into water. One of the tools that can be used for the sustainability assessment of pollution discharge into water is the water footprint. The paper calculates the grey water footprint of large municipal wastewater treatment plants in the Ohře River basin, located in the Czech Republic. Municipal wastewater treatment plants listed by the state-owned enterprise Povodí Ohře in Water Balance Management reports were selected for the analysis. The receiving body assimilation capacity for individual pollutants was determined and the grey water footprint at the inlet and outlet of the WWTP was calculated. Subsequently, the sustainability assessment of the WWTP discharges were carried out and related to the long-term average flow rates in the receiving water body. The analyses showed that the assimilation capacity of the watercourse is mostly utilized by the discharge of total phosphorus and ammonia nitrogen. The analysis also showed that (with some exceptions) the wastewater treatment plants treat water sufficiently and the assimilation capacity of the watercourse is not exhausted.
Instagram as Media in Teaching Writing Recount Text for Senior High School Students
Authors: Basith Abdul -
Published: January 2020

Social media is web-based application that allows users to communicate, collaborate, and share resources with other people. Both being easy to access and easy to use make social media become an effective way to communicate and exchange ideas. Students can use social media to keep up with their friends, to stay up-to-date with news and current events, to fill up spare time, to find entertaining content, and to share opinions. The use of social media becomes famous for the students nowadays. Thus, the popularity of the social media among students can be used as a tool in language teaching. One of the famous social media is Instagram. Instagram is a social network that enables its users to take pictures and videos, and share them publicly or privately on the application, as well as through a variety of other social network. Through Instagram the students can post their photos or videos that can be commented by viewers. By using Instagram, teachers are offered great opportunity to develop classroom activities creatively. This paper will give an overview of the use of Instagram in teaching writing recount text in senior high school students.
Electromagnetic Inversion with Local Power Conservation for Metasurface Design
Authors: Brown Trevor , Vahabzadeh Yousef , Caloz Christophe , Mojabi Puyan
Published: January 2020

A method based on electromagnetic inversion is extended to facilitate the design of passive, lossless, and reciprocal metasurfaces. More specifically, the inversion step is modified to ensure that the field transformation satisfies local power conservation, using available knowledge of the incident field. This paper formulates a novel cost functional to apply this additional constraint, and describes the optimization procedure used to find a solution that satisfies both the user-defined field specifications and local power conservation. Lastly, the method is demonstrated with a two-dimensional (2D) example.
Full-Wave Verification of an Electromagnetic Inversion Metasurface Design Method
Authors: Brown Trevor , Liu Ziqi , Mojabi Puyan
Published: January 2020

This paper summarizes, extends, and synthetically evaluates a method for metasurface design which uses electromagnetic inversion. After the inversion algorithm determines a homogenized surface susceptibility model to implement a desired power pattern, the susceptibility distribution is converted to a three-layer admittance sheet topology. Lastly, full-wave commercial software is used to simulate and verify the performance of a metasurface designed and implemented using the proposed procedure.
Disegnare linee nel paesaggio
Authors: Morelli Emanuela
Published: January 2020

La presente ricerca ha come oggetto la progettazione delle grandi infrastrutture viarie, solitamente autostrade o superstrade, quali casi limite del controverso rapporto infrastruttura/paesaggio. Nel ripercorrere circa un secolo di realizzazioni e di teorie dal punto di vista del paesaggio, paesaggio inteso appunto nel suo significato più ampio e di sistema, e in tutti i suoi aspetti culturali, ecologici e percettivi, il fine è quello di individuare una metodologia, o più precisamente una filosofia progettuale di base, utile ad indirizzare le trasformazioni indotte in termini qualitativi: infrastruttura quindi non più in oggetto contrapposizione al paesaggio ma parte integrante di esso.
Los estilos de pensamiento y su rol dentro de los procesos de enseñanza - aprendizaje
Authors: Almanza Cárcamo Darilys , Herrera Rodríguez Viany , Barros Fuentes Carlos
Published: January 2020

Si preguntamos de donde surge el conocimiento la respuesta de algunos puede ser: por  transmisión, y para muchos otros surge de la interacción social. Todas estas respuestas de cierta forma son válidas dado que se debe tener en cuenta el Estilo de Pensamiento de quien responde y el enfoque epistemológico en el cual se basa.

Dentro del contexto de la educación los procesos de enseñanza.- aprendizaje se ven inminentemente permeados por  patrones cognitivos, que reflejan el estilo de pensamiento del docente, de cómo su marco teórico lo lleva a influir en los resultados de aprendizaje de sus estudiantes, y a su vez, como el estudiante recibe el contenido desarrollado por el docente.
Measuring and Tracking Code Quality in ROS
Authors: Pitzer Benjamin
Published: January 2020

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TRANSFORMATION OF ARRESTED SMALL-MOTOR MOVEMENTS IN AUTOMATED IN THE PROCESS OF RETROACTIVE TRAINING OF PATIENTS WITH ISCHEMIC STROKE
Authors: Nikishina V B , Petrash E A , Nikishina E I
Published: January 2020

Objective: to study the transformation of arbitrary small motor motions into automated (which form the basis of self-service skills) in the process of restorative education of patients who underwent ischemic stroke. Materials and methods: the material of the study is a sample of patients who underwent ischemic stroke, hemispheric localization (53 people). As a method, a complex of neuropsychological tests, hardware methods of diagnostics and restorative training were used. Results: The dynamics of restoration of small motor motions in automated actions that make up self-care skills for patients who underwent ischemic stroke, regardless of the lateralization profile and hemispheric localization of the lesion focus, is characterized by self-sufficient precision performance of automated small-engine actions that constitute self- service skills. It is established that there is no degeneration of the formed skills in time, provided it is used periodically; as well as a positive motivation to use the formed skills of self-service.
Las favelas en Río de Janeiro y el turismo alternativo de pobreza
Authors: Kotarski Jędrzej
Published: January 2020

Las grandes aglomeraciones latinoamericanas hoy en día son espacios de fuertes desigualdades y diferencias sociales. Los suburbios de las ciudades brasileñas, a pesar del desarrollo impresionante del país y publicitada política del suceso, se componen de cientos de barrios pobres -llamados favelas- los cuales, como en un lente, enfocan los problemas de sus habitantes. Las más conocidas son las favelas de Río de Janeiro gracias a películas muy populares en la escala global como «La Ciudad de Dios» o «Tropa de Elite». Este artículo trata de las favelas como escenas de nuevas formas de turismo y sobre el fenómeno de vender las imágenes de la pobreza en algunos de los barrios más conocidos como Favela Rocinha. Normalmente las visitas son dedicadas a un tipo de turistas (generalmente los más ricos) y tienen varios objetivos. Muestran pruebas de aprovechamiento de la demanda de «el exotismo cotidiano» que existe entre los turistas, pero también tiene que eliminar los estereotipos injustos (se identifica los habitantes de las favelas con los narcotraficantes) e ilustrar como realmente se puede ayudar a los pobres.
МОДЕЛЮВАННЯ ПРОЦЕСУ ЗВОРОТНЬОГО ВИДАВЛЮВАННЯ ПОРИСТИХ ЗАГОТОВОК
Authors: А.О. Михайлов  , О.В. Михайлов  , М.Б. Штерн
Published: January 2020

Методом комп'ютерного моделювання досліджено процес зворотнього видавлювання спечених порошкових заготовок. Розглянуто вплив наявності недосконалих контактів між частинками порошку. Встановлено, що на початковому етапі відбувається осад та ущільнення заготовки, а потім починає переважати процес видавлювання. Розподіли величин залишкової пористості та накопиченої пластичної деформації матеріалу за об'ємом виробу нерівномірні. Безпосередньо під деформуючим пуансоном знаходиться зона затрудненої деформації. Мінімальні щільність і накопичена деформація відповідають області у вільній від навантаження поверхні. Наявність недосконалих контактів призводить до появи зон розущільнення порошкового матеріалу та зменшення величини накопиченої пластичної деформації в цих зонах.
МАТЕМАТИЧНА МОДЕЛЬ МІЖФАЗНОЇ ТРІЩИНИ В ПЛАСТИНЦІ З ПІДСИЛЕНИМ КРУГОВИМ КОНТУРОМ ПРИ ЇЇ ЗГИНІ
Authors: А. Сяський  , В. Кот  , В. Вороницька
Published: January 2020

Побудовано математичну модель задачі про підсилення замкненим пружним ребром контуру кругового отвору в нескінченній ізотропній пластинці, яка перебуває в умовах циліндричного згину на нескінченності, за наявності на межі поділу матеріалів міжфазної тріщини (розрізу), береги якої в процесі деформації не контактують. Наближений розв’язок системи сингулярних інтегрально-диференціальних рівнянь задачі здійснено методом механічних квадратур і колокації. Розглянуто числовий приклад.
ЛАБОРАТОРНІ ДОСЛІДЖЕННЯ ВПЛИВУ РОБОЧИХ ПАРАМЕТРІВ СІРКОВОДНЕВИХ СЕРЕДОВИЩ НА ШВИДКІСТЬ КОРОЗІЇ ТРУБНИХ СТАЛЕЙ
Authors: Г.В. Чумало  , Є.В. Харченко  , А.О. Кичма  , В.М. Палюх
Published: January 2020

Досліджено вплив складу середовища, його температури і тиску на швидкість корозії трубних сталей Р-105, сталі 20 і, для порівняння, листової сталі 20. Показано, що в інтенсивно перемішуваному хлоридному середовищі з домішками Н2S і СО2 швидкість корозії низьколегованих сталей у рідинній фазі вища, ніж у парогазовій: за температури 25°С – у 2 рази, за температури 60°С – у 3 рази, а за температури 95 °С – у 4 рази. Встановлено, що найбільш корозійнотривкими є листова і трубна сталь 20, а найменш тривкою – сталь Р-105. Показано, що сталь 20 схильна до поверхневого пухиріння, на відміну від сталі Р-105, яка є стійкою до цього виду руйнування.
ІДЕНТИФІКАЦІЯ ОБ’ЄКТІВ МАШИНОБУДУВАННЯ ЗА КІЛЬКОМА КІЛЬКІСНИМИ ОЗНАКАМИ ОДНОЧАСНО
Authors: С.В. Ковалевський  , О.С. Ковалевська
Published: January 2020

Показано, що діагностика об'єктів машинобудування передбачає обґрунтування розширення застосовуваних фізичних ефектів, орієнтованих, в першу чергу, на неруйнівного контролю параметрів продукції машинобудування. На підставі досліджень, які показують перспективність експериментальних і теоретичних доказів, доведена доцільність пошуку підтвердження інформативності частотних спектрів резонансних акустичних сигналів досліджуваних об'єктів, порушених широкосмуговими резонаторами рівній амплітуди в акустичному діапазоні. Надані прикладі застосування широкосмугових випромінювачів наноамплітудних впливів на досліджувані об'єкти з метою акустичної спектроскопії для створення їх ідентифікаційних моделей. Для практичного використання експериментальних результатів для ідентифікації розмірних і фізико-механічних характеристик станів діагностованих об'єктів авторами застосовані нейромережні моделі. Такі моделі служать практичним цілям діагностики станів об'єктів на основі частотних спектрів власних резонансних коливань. Доведено, якщо діагностика об'єкта проводиться щодо опорного сигналу у вигляді широкосмугового впливу постійної амплітуди, то такий підхід дозволяє нормувати вихідні діагностичні сигнали щодо опорного сигналу. представлені ідентифікаційні моделі, побудовані на нейромережному базисі, показали реальну можливість їх використання для створення системи діагностики об'єктів за кількома кількісними ознаками. Причому, кількість таких ознак, які можна контролювати одночасно, практично, не обмежена. Авторами роботи проведені додаткові дослідження, які показали можливість одночасного контролю не тільки геометричних характеристик об'єктів, а й їх фізико-механічних характеристик, включаючи показники напруженого стану, твердості і т.ін..
Ein neues System zur graphematischen Transliteration der altägyptischen Hieroglyhenschrift
Authors: Breyer Francis
Published: January 2020

“A new system for transliterating Egyptian hieroglyphs graphematically”
The way in which Egyptologists transcribe non-Egyptian words in Egyptian texts is not only very inconsistant, but also very inadequate. Although there have been several attempts to change this, none of these systems has been convincing. Here we propose a new approach for transliterating lexemes written in Egyptian sign by sign, which is based on the transliterations used in different neighboring disciplines.
keywords: Transliteration, Syllabische Schrift, Gruppenschrift, Fremdwörter, Umschrift
Some Notes Concerning the Texts on the Two Brothers’ Coffins in Context
Authors: Landborg Anne
Published: January 2020

This paper discusses the so-called ornamental use of texts on the late Middle Kingdom coffins belonging to Nakht-ankh and Khnum-nakht, the famous “Two Brothers”. The texts include heavily shortened versions of Pyramid- and Coffin Texts spells that the copyists apparently did not attempt to include in their entirety. Yet they can be seen to have made a number of conscious editorial decisions and selected the texts from a small closed set of spells, suggesting that their intent was not merely decorative. It is argued that the ornamental use of funerary texts represents a local religious tradition where the excerpts served as tokens and magical substitutes for the larger compositions from which they derive.
Coptic Circumstantial Periphrasis
Authors: Speransky Nina
Published: January 2020

The paper looks into the history and synchrony of the Coptic periphrastic pattern, suggesting that the diathesis might be one of the factors triggering its usage. Contrary to the well-established opinion, it is demonstrated that Coptic periphrastic constructions do not have inchoative semantics. The paper also examines the lexical repertory of the pattern and formulates grammatical conditions triggering the use of periphrastic constructions.
A Espacialidade do Melancólico – Parte I
Authors: Tellenbach Hubertus
Published: February 2020

São descritas alterações da vivência espacial em três pacientes com melancolia endógena. Após a exposição dos pressupostos metodológicos, que estão dados na compreensão de espaço de Kant e Leibniz, faz-se a análise dos distúrbios. Há alterações na vivência do espaço circundante natural e orientado e do “espaço interior”. Uma tentativa de explicar esses distúrbios a partir de pressupostos metodológicos (categoriais) da vivência espacial leva a contradições insolúveis. Estas levam a questionamentos, dentre os quais, formulam-se alguns.
RESENSI BUKU : ASIAN BIBLICAL HERMENEUTICS AND POSKOLONIALISM; CONTESTING THE INTERPRETATIONS
Authors: TALUPUN JOHANA SILVANA
Published: February 2020

Buku Asian Biblical Hermeneutics and Poskolonialism; Contesting the Interpretations ditulis oleh R.S.Sugirtharajah, seorang Profesor di bidang Biblical Hermeneutic. Ia lahir di Sri Lanka dan memiliki pendidikan pascasarjana di India dan Inggris. Sebagai seorang pakar di bidang Biblical Hermeneutic tentu banyak karya telah dihasilkannya yang berhubungan dengan studi Alkitab. Dua karya yang dirintisnya dan sangat di kenal dunia adalah teori kritis tentang studi Alkitab yaitu postcolonial criticism dan perhatiannya pada marginal interpretative voice dengan bukunya yang sangat terkenal yaitu Voices from the Margin.Buku Asian Biblical Hermeneutics and Poskolonialism; Contesting the Interpretations yang merupakan kumpulan esai dari hasil penelitiannya di India. Tesis yang didikembangkannya adalah sebuah pendekatan hermeneutik Alkitab yang dirasa lebih cocok untuk dikembangkan di Asia. Pendekatan hermeneutik ini dipakainya untuk menentang pendekatan hermeneutik lain yang sudah dikembangkan sebelumnya. Buku ini dibagi atas dua bagian. Bagian pertama terdiri dari empat bab dan bagian kedua, tiga bab. Hasil penelitian itu menunjukkan bahwa kolonialisme telah memainkan peran yang penting pada interpertasi terhadap tradisi keagamaan baik Hindu  maupun Kristen di India selama dan setelah Inggris berkuasa.
Perancangan Intelligent Tutoring System Menggunakan Chatbot pada Mata Pelatihan Barang Dalam Keadaan Terbungkus
Authors: Febriantoro Wicaksono , Nurhadi Achmad
Published: January 2020

ASN mempunyai kewajiban pengembangan kompetensi selama minimal 20 JP/tahun. Akan tetapi tidak semua ASN dapat mengikuti pelatihan sebagai bentuk pengembangan kompetensi dikarenakan terbatasnya kuota/jumlah pelatihan tatap muka (klasikal) yang tersedia. Regulasi terbaru memberikan alternatif pembelajaran non klasikal yang tidak harus bertatap muka antara lain e-learning, distance learning dan belajar mandiri. Belajar mandiri dapat digunakan siswa untuk meningkatkan kompetensinya menggunakan berbagai sumber belajar yang tersedia baik konvensional dan berbasis pada teknologi informasi. Dalam paper ini akan dibahas salah satu tools pendukung belajar mandiri berupa perancangan intelligent tutoring system menggunakan chatbot pada mata pelatihan barang dalam keadaan terbungkus (BDKT). Perancangan menggunakan framework Design Science Research, mulai dari penetapan tujuan, perancangan desain alur percakapan chatbot, pengembangan aplikasi menggunakan chatfuel, demonstrasi melalui simulasi via Facebook Messenger dan Evaluasi Blackbox. Prototype yang dihasilkan telah dapat mengikuti alur percakapan yang dirancang dan dapat digunakan sebagai pendukung belajar mandiri kapan saja dan dimana saja (domain pelajari materi dan evaluasi) asalkan terkoneksi dengan internet.
Polydatin Alleviates Lipopolysaccharide-Triggered Inflammatory Injury Through Up-Regulating miR-125b in Chondrogenic ATDC5 Cells
Authors: Haifeng Liu , Fan Zhang , Huiming Wu , Qinglai Wang , Kuixian Zhang , Xiaoshuai Zeng
Published: January 2020

Osteoarthritis is a bone-joint disease prevalent in older people characterized by joint inflammation. In traditional Chinese medicine, polydatin plays an important anti-inflammatory role. This study analyzed the potential effects and possible internal mechanisms of polydatin on osteoarthritis. First, lipopolysaccharide-induced osteoarthritis injury was established in chondrogenic ATDC5 cells. Lipopolysaccharides significantly stimulated inflammatory injuries in ATDC5 cells as exemplified by a decrease in cell viability and an increase in inflammatory cytokine secretions including interleukin-6, tumor necrosis factor-a, and interleukin-1. Moreover, lipopolysacchrides also increased Cleaved caspase-3 and Cleaved Poly (ADP-ribose) polymerase to promote cell apoptosis. Second, polydatin showed significant protective effects against lipopolysaccharide-induced inflammatory injury, again exemplified by increased cell viability, decreased inflammatory cytokines, Cleaved caspase-3, and Cleaved poly (ADP-ribose) polymerase. Lastly, miR-125b and its binding target Rho-Associated Coiled-Coil Containing Protein Kinase 1 were closely associated with regulatory effects of polydatin against lipopolysaccharide-stimulated ATDC5 cell inflammatory injuries. Polydatin alleviated lipopolysaccharide-stimulated inflammatory injuries via the down-regulation of miR-125b. The present study concludes that polydatin plays an anti-inflammatory role in lipopolysaccharide-stimulated ATDC5 cell inflammatory injuries via the down-regulation of miR-125b.
Health Benefits of a Combination Probiotics; FlorMidabil™
Authors: S. Latvala , S. Philipp , M.J. Lehtinen , L. Lehtoranta , A.C. Ouwehand
Published: February 2020

This review summarizes health benefits of a combination of a four-strain probiotic consisting of L. paracasei Lpc-37, B. lactis Bl-04, L. acidophilus La-14, and L. plantarum Lp-115. The safety of the individual strains for absence of transferable antibiotic resistance and adverse events in human intervention studies has been documented. The strains have been shown, both in vitro and in human studies, to survive gastro-intestinal transit and transiently colonize the intestine in a dose-dependent manner. In digestive health, the strains have shown to modulate the intestinal microbiota and reduce risk for both diarrhea and constipation. In vitro, animal and human studies have shown these strains to positively modulate many immune markers, in particular anti-inflammatory markers. These modifications also suggest a reduced risk for respiratory tract infections and seasonal respiratory allergies. The strains contributed positively to weight management in humans and reduced markers of metabolic syndrome in animal models. Finally, one of the strains (L. acidophilus La-14) was shown to colonize the vagina and contribute to reduced risk for recurrent bacterial vaginosis, vulvovaginal candidiasis and urinary tract infection. The combination of these four strains can therefore be expected to provide a broad spectrum of health benefits.
Estimation of the Effects of Food on the Pharmacokinetic Results in Bioequivalence Studies
Authors: Mircioiu Ion , Anuta Valentina , Mircioiu Constantin , Voicu Victor , Sandulovici Roxana
Published: February 2020

Paper presents the effect of food on the pharmacokinetics of omeprazole and on the extraction yield of its internal standard, lansoprazole. The experimental data were obtained over three bioequivalence studies performed by the authors. Statistical analysis of plasma level curves of omeprazole indicated that food induces a delay of the time of maximum concentrations, but had a lower effect on maximum concentration and area under curves. Peak areas of lansoprazole were not constant, presenting a similar pattern in all seven periods of the clinical experiment, both in feeding and fasting conditions: an increase after the standard meal at four hours from the administration of drug followed by relatively constant, but higher areas afterwards. Statistical analysis of data (1500 points) in the 3 - 6 h interval, i.e. from immediately before until two hours after food intake revealed a two phase effect: an initial decrease of areas followed by an increase to a higher level than in the preprandial conditions, leading to the appearance of a minimum in curves one hour after food intake. In almost all cases a good parabolic fitting of data was obtained, which is in agreement with authors previous results on extraction of ketoconazole from pasma in methylene chloride in the presence of bile salts. The increase of peak areas of lansoprazole from two hours after meal by 24 h lead to an artificial decrease of calculated omeprazole concentrations. This effect could explain the unexpected lack of food effect on the area under curve of omeprazole, observed in the comparison between areas in fasting and fed conditions.
Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia
Authors: Moisa Cornel , Gaman Mihnea Alexandru , Diaconu Camelia Cristina , Gaman Amelia Maria
Published: February 2020

Essential thrombocythemia (ET) is a BCR-ABL1-negative myeloproliferative neoplasm associated with thrombotic and haemorrhagic complications. Reactive oxygen species (ROS) overexpression induces a growth advantage to JAK2V617F-positive clones and, in association with a higher number of immature platelets, leukocytosis, and additional cardiovascular risk factors, leads to an increased risk for thrombotic events. We evaluated oxidative stress by measuring ROS levels and the total antioxidant capacity (TAC) in 62 ET patients and investigated the relationship between oxidative stress, JAK2V617F mutational status and the development of thrombotic events. We found higher oxidative stress levels in JAK2V617F-positive vs. JAK2V617F-negative ET cases with no significant differences between homozygous and heterozygous genotypes. Increased ROS levels and thrombotic events were more frequent in ET patients with old age at diagnosis, higher haematocrit levels or leukocytosis.
In-silico Optimization of a Batch Bioreactor for mAbs Production in Relationship to the Net Evolution of the Hybridoma Cell Culture
Authors: Maria Gheorghe , Gijiu Cristiana Luminita , Cebanu Iulian , Maria Cristina , Tociu Carmen
Published: February 2020

Bioreactor optimization is a common engineering problem difficult to be solved due to the large number of influential variables of high variability. Production of monoclonal antibody is a well-known method to synthesize a large number of identical antibodies (that is of uniform characteristics, also called monoclonal antibodies, mAb). Due to such reasons intense efforts have been invested to maximize the production of mAb by using hybridoma cell culture. Based on an adequate kinetic model from literature (experimentally checked) this paper focus on pointing-out the major role of the net evolution of the viable biomass (growth, and decay) in the location of the optimal operating setpoint (SP) of a three-phase mechanically agitated batch bioreactor (TPMAB) with immobilized hybridoma culture. This in-silico analysis opens the possibility I) to optimize the bioreactor performances by placing the SP in the most favourable location, by adjusting the substrate and biomass initial load in the bioreactor according to the preliminary determined characteristics of a modified / improved biomass; ii) to optimize the batch-to-batch operation mode (not approached here) according to the time-varying characteristics of the biomass culture, or iii) to determine the optimal operation of the bioreactor in a fed-batch operating mode (not approached here).
ANALISIS PENGENDALIAN PERSEDIAAN BAHAN BAKU PRODUK SEPATU KULIT DENGAN MENGGUNAKAN METODE MATERIAL REQUIREMENT PLANNING (MRP) (STUDY KASUS CV. KOTAMA SHOES)
Authors: Yusnita Erni , Derlini Derlini
Published: January 2020

Penelitian ini bertujuan untuk mengetahui pemesanan bahan baku yang efisien, meminimalkan biaya persediaan bahan baku dan mengetahui metode alternatif  pengendalian persediaan bahan baku yang dapat digunakan oleh perusahaan. Penelitian ini dilakukan di CV. Kotama Shoes yang beralamat di Jalan A.R. Hakim No. 112/206 C Medan, Sumatera Utara. Perusahaan ini bergerak di bidang produksi pembuatan sepatu kulit. Metode yang digunakan dalam penelitian ini adalah metode Material Requirement Planning (MRP) dengan menggunakan 3 (tiga) teknik yaitu Lot For Lot (LFL), Economic Order Quantity (EOQ) dan Period Order Quantity (POQ). Pengumpulan data dalam penelitian ini dilakukan dengan cara wawancara langsung kepada pemilik perusahaan dan melihat langsung kondisi di perusahaan yang datanya berhubungan dengan penelitian ini. Berdasarkan hasil analisis diperoleh bahwa metode MRP dengan teknik LFL, EOQ dan POQ efektif dalam menghemat biaya persediaan yang dilakukan oleh perusahaan. Biaya yang dikeluarkan oleh perusahaan dengan metode perusahaan lebih besar dibandingkan dengan metode MRP teknik LFL, EOQ dan POQ.
POTENSI SERPENTINIT UNTUK PEMANFAATAN BAHAN BAKU PUPUK MINERAL
Authors: Ardiansyah Edi Yasa , Syafriadi Syafriadi , Tibri T. , Eka Onwardana M. , Sungen Sungen
Published: January 2020

Batuan serpentinit adalah salah satu sumber mineral magnesit ini, diketahui memiliki kandungan unsur magnesium (Mg) besar, sehingga dapat dimanfaatkan sebagai bahan baku pupuk yang cukup menguntungkan, karena akan diperoleh unsur magnesium (Mg) dalam jumlah besar (Jarot, 2008). Daerah penelitian mempunyai sebaran bahan galian serpentinit sekitar 157.100 m2 dan jumlah tonase sumberdaya serpentinit tereka 136.151.807,3 ton. Berdasarkan hasil analisis kimia serpentinit mengandung unsur magnesium yakni 20 – 50%. Dari hasil analisa laboratorium pada batuan serpentinit ini layak untuk dimanfaatkan sebagai bahan baku pupuk mineral yang mutu dan memenuhi Standar Industri Indonesia .
PENGGUNAAN ABU CANGKANG SAWIT DAN SEMEN UNTUK MENINGKATKAN KEPADATAN TANAH LEMPUNG DESA TANJUNG REJO
Authors: Agung Ramahdana Debby Endriani
Published: January 2020

Tanah yang terdapat di daerah Dusun Paloh 80, Desa Tanjung Rejo, Kecamatan Percut Sei Tuan, Kabupaten Deli Serdang, Sumatera Utara merupakan tanah lempung yang memiliki sifat kembang susut tinggi dan daya dukung tanah yang rendah sehingga tingkat kestabilannya rendah. Oleh karena itu, harus dilakukan suatu metode stabilisasi tanah lempung agar mendapatkan tanah yang stabil. Tujuan penelitian ini adalah untuk mengetahui tingkat kepadatan tanah dilapangan berdasarkan kepadatan dilaboratorium melalui uji sand cone berdasarkan SNI 03-2828-1992. Stabilisai tanah lempung menggunakan abu cangkang sawit dan semen. Abu cangkang sawit yang digunakan untuk penelitian ini diperoleh dari PT. Multi Agro Sumatera, Kabupaten Serdang Bedagai, Sumatera Utara dan semen yang digunakan adalah semen portland. Pengujian yang dilakukan di Laboratorium Mekanika Tanah Teknik Sipil Politeknik Negeri Medan untuk memperbaiki sifat fisik tanah dan mekanik tanah lempung. Pengujian sand cone dilakukan secara langsung dengan mengukur volume tanah yang digali. Alat yang digunakan terdiri dari botol kaca diisi dengan pasir ottawa kering lalu dipasang dengan kerucut logam. Penggunaan abu cangkang sawit dan semen pada tanah lempung dapat merubah sifat fisik tanah yaitu terjadi penurunan indeks plastisitas tanah lempung dan pada sifat mekanik tanah yaitu diperoleh kadar air optimum dan berat isi kering maksimum yang menjadi acuan untuk pengujian kepadatan tanah di lapangan. Dari hasil pengujian kepadatan tanah di lapangan diperoleh persentase rata-rata kepadatan sebesar 82,42%. Nilai yang diperoleh tersebut belum mencapai kepadatan yang maksimal, sehingga tanah perlu dipadatkan kembali.
HOLISM IN THE EFL CLASSROOM: The Impact of Implementing Suggestopedia Method in Enhancing Students’ Performance in Speaking Skill in Libyan Secondary Schools: A Case Study of Al Wifak Secondary School- Kufrah
Authors: Al Jawad Ahmed
Published: February 2020

This study was set out to investigate the impact of implementing Suggestopedia Method in EFL classroom in Libyan secondary schools. This study attempted to investigate how possible students’ performance in speaking skill could be increased through Suggestopedia Method.
ERITROBLASTOS VACUOLADOS EN UNA PACIENTE CON VIH E INFECCIONES OPORTUNISTAS.
Authors: Díaz García Juan , Carrera Patiño Fabian
Published: February 2020

El presente caso es una presentación poco común de la presencia de eritroblastos vacuolados  en una paciente con VIH y con otras comorbilidades asociadas tales como Histoplasmosis e infección por Parvovirus B19, donde hasta ahora no existen reportes de este hallazgo en pacientes con estas patologías de manera conjunta, sin ser una evidencia patognomónica de alguna enfermedad en especial y sin conocerse aún el mecanismo de aparición de estos en médula ósea.
Pemantauan Ekosistem Lamun Pulau Pari dan Pulau Tikus
Authors: Rustam Agustin
Published: January 2020

Monitoring atau pemantauan yang dilakukan terhadap ekosistem lamun pada lokasi permanen diperlukan mendapatkan sumber masalah dan solusi untuk  pengelolaan ekosistem yang berkelanjutan. Penelitian ini dilakukan tahun 2012 di perairan Gugusan Pulau Pari, Kabupaten Kepulauan Seribu, DKI Jakarta dengan pemasangan lokasi permanen di dua pulau, Pulau Pari dan Pulau Tikus. Tujuan penelitian ini mendapatkan dinamika kondisi eksisting ekosistem lamun melalui pendekatan persentase tutupan lamun. Metode penelitian dilakukan dengan survei lapangan yang berkelanjutan (monitoring), penentuan lokasi permanen berdasarkan hipotesa Pulau Pari terpengaruh aktivitas daratan, Pulau Tikus tidak terpengaruh. Hasil penelitian jenis lamun yang ditemukan di gugusan Pulau Pari ada tujuh jenis. Hasil  monitoring terlihat adanya kecenderungan penurunan persentase penutupan lamun dan berkurangnya spesies lamun di Pulau Pari, sedangkan di Pulau Tikus terlihat stabil. Aktivitas pembangunan yang berlangsung di Pulau Tengah berperan cukup besar atas penurunan persentase tutupan lamun di Pulau Pari selama penelitian, juga potensi pencemaran limbah domestik dari masyarakat lokal maupun dari wisatawan. Pemantauan pada lokasi permanen perlu dilanjutkan sehingga permasalahan yang terjadi dengan ekosistem di Gugusan Pulau Pari dapat dicari solusinya. Misalnya terkait dengan tingginya aktivitas wisatawan, perlu pembelajaran tentang ekowisata yang baik bagi wisatawan dan masyarakat lokal, misalnya dalam penanganan limbah. Sehingga diharapkan pemanfatan ekosistem yang berkelanjutan dalam tujuan pembangunan berkelanjutan dapat dilakukan.
Diretrizes políticas de inclusão escolar que direcionam o acesso na educação infantil em municípios goianos
Authors: Nunes Monica Isabel Canuto , Tartuci Dulcéria
Published: February 2020

O acesso e permanência das crianças público-alvo da educação especial na educação infantil é um direito subjetivo, portanto, deve ser garantido pelos sistemas municipais de ensino. Este artigo objetiva analisar as diretrizes políticas de seis municípios da Microrregião de Pires do Rio-Goiás GO, que direcionam ou não o acesso das crianças público alvo da educação especial na educação infantil. Refletindo que, ao adotar o paradigma de atendimento dessas crianças na rede regular de ensino, surgem demandas em relação às ações específicas de inclusão. Trata-se de uma pesquisa exploratória do tipo qualitativa que utilizou-se de análise documental e de roteiros de entrevistas semiestruturadas. Participaram do estudo seis secretários municipais de educação e seis diretores de instituições de educação infantil que tinham crianças público alvo da educação especial matriculadas neste nível de ensino. Os dados sinalizam que, mesmo sendo irrisório o número de matrículas na educação especial, houve uma elevação no ano de 2010, na maioria dos municípios. Em 83% dos municípios constata-se que, as crianças público alvo da educação especial, não estão tendo garantido o seu direito social e humano de inserção escolar na creche. Os gestores demonstram não haver diretrizes políticas voltadas à educação especial e inclusão nos municípios pesquisados.
Human free-operant performance varies with a concurrent task: Probability learning without a task, and schedule-consistent with a task
Authors: Reed Phil
Published: February 2020

Three experiments examined human rates and patterns of responding during exposure to various schedules of reinforcement with or without a concurrent task. In the presence of the concurrent task, performances were similar to those typically noted for nonhumans. Overall response rates were higher on medium-sized ratio schedules than on smaller or larger ratio schedules (Experiment 1), on interval schedules with shorter than longer values (Experiment 2), and on ratio compared with interval schedules with the same rate of reinforcement (Experiment 3). Moreover, bout-initiation responses were more susceptible to influence by rates of reinforcement than were within-bout responses across all experiments. In contrast, in the absence of a concurrent task, human schedule performance did not always display characteristics of nonhuman performance, but tended to be related to the relationship between rates of responding and reinforcement (feedback function), irrespective of the schedule of reinforcement employed. This was also true of within-bout responding, but not bout-initiations, which were not affected by the presence of a concurrent task. These data suggest the existence of two strategies for human responding on free-operant schedules, relatively mechanistic ones that apply to bout-initiation, and relatively explicit ones, that tend to apply to within-bout responding, and dominate human performance when other demands are not made on resources.
A revision of the extant species of Theodoxus (Gastropoda, Neritidae) in Asia, with the description of three new species
Authors: Sands Arthur F. , Glöer Peter , Gürlek Mustafa E. , Albrecht Christian , Neubauer Thomas A.
Published: February 2020

Asia contains a high species diversity of the freshwater gastropod genusTheodoxus. Recent molecular and morphological reviews of this diversity have uncovered a number of yet undescribed species while suggesting the urgent revision of several others. Moreover, some of these studies have indicated a number of species previously not recorded for this continent. Despite the advancements, a taxonomic revision and an update on the distribution ofTheodoxusspp. in Asia is still pending. Here, we construct the most robust phylogeny ofTheodoxusup to now and review original descriptions, type material, recent taxonomic revisions, compendia, and species lists to provide a comprehensive checklist of all known extant AsianTheodoxusspp. Our checklist also provides descriptions for three recently discovered and yet undescribed species (Theodoxus gururSands & Glöer,sp. nov.,Theodoxus wesselinghiSands & Glöer,sp. nov., andTheodoxus wilkeiSands & Glöer,sp. nov.), as well as shows the need to synonymise several previously described morphospecies. The present revision recognizes 14 extantTheodoxusspp. for Asia. Some of these species are widespread, while others are endemic to just a single location. Based on the revised and new distribution data, we provide updates and new assessments of species conservation statuses.
Immunological Characteristics and Management of Kidney Transplantation
Authors: Kim Myung-Gyu
Published: February 2020

Kidney transplantation (KT) is the best way to improve the quality of life and survival of patients with end-stage renal disease. However, after KT the adaptive immune system plays important roles in the development of rejection via multiple pathways. Accordingly, the suppression or modulation of these pathways is key to allograft survival. Advances in our understanding of the immunology related to KT with the development of immunosuppressants have reduced the rate of acute rejection and improved short-term transplant outcomes. Nonetheless, de novo donor-specific antibodies and subsequent chronic rejection continue to be responsible for the poor long-term survival of transplanted patients. In addition, the morbidity and mortality rates in patients returning to dialysis after graft failure are high. Better long-term outcomes following KT require innovative treatment strategies that include a focus on de novo antibodies. Here, we review basic transplant immunology as well as the diagnostic tools and medications that contribute to successful KT. We also provide an update on newly developed immunosuppressants.
La philosophie du langage dans l’architectonique du système fichtéen
Authors: Radrizzani Ives
Published: January 2020

Le but de cette contribution est d’identifier la place du langage dans l’architectonique du système fichtéen. Il est apparu (1) que la déduction du langage appartient de droit à la partie principielle du système ; (2) que l’intégration de cette déduction dans la partie principielle s’est faite, comme pour la doctrine de l’intersubjectivité, par la prise en compte de considérations initalement développées dans un écrit ne relevant pas directement de la Doctrine de la Science ; (3) qu’en tant que support de la sollicitation, le langage joue un rôle crucial dans la genèse de la conscience, dont il constitue la condition suprême et (4) qu’il est directement lié à la solution proposée par Fichte pour remédier à l’« inachèvement du système kantien ».
Fichte et la puissante impuissance du langage
Authors: Garcia Luis Fellipe
Published: January 2020

Cet article montre que Fichte développe une originelle conception du langage dans ses Discours à la Nation allemande d’où il ressort non seulement le besoin de retraduire des concepts philosophiques dans un langage populaire comme aussi celui de formuler un langage plus malléable pour la philosophie en tant que telle. Afin d’explorer cette hypothèse, notre propos suivra les étapes suivantes : (i) nous analyserons la conception fichtéenne du rapport entre popularisation et flexibilisation du langage, ce qui nous permettra (ii) d’explorer les raisons systématiques du rapprochement entre langue philosophique et langue populaire et (iii) de saisir précisément la compréhension du rôle philosophique du langage qui en découle.
Effets du travail en horaires alternés sur la qualité de vie et la vigilance en Tunisie
Authors: Chaouch Nesrine , Mechergui Najla , Aissi Wafa , Essid Dorra , Khemila Tessnim , Ladhari Nizar
Published: January 2020

Introduction : Le travail en horaires alternés est connu pour être pourvoyeur de troubles de la santé physique et psychique chez les salariés, pouvant altérer leur qualité de vie et de sommeil. Objectif  : L’objectif de cette étude était d’évaluer la qualité de vie et la vigilance des travailleurs travaillant en horaires alternés. Résultats  : Au total, 391 salariés ont répondu au questionnaire. Selon le type d’horaires, 320 salariés travaillaient en horaires alternés de type 2 × 8 et 71 travaillaient en horaires de nuit permanents. Le groupe de salariés travaillant la nuit en permanence avait un niveau de qualité de vie plus élevé que le groupe de salariés travaillant en 2 × 8 en termes de score global, score physique et score mental ( p  < 10 –3 ). La fréquence des signes de somnolence diurne excessive était significativement plus élevée chez les travailleurs de type 2 × 8. Conclusions  : Notre étude a montré que l’alternance des rythmes de travail semble avoir des effets néfastes sur la qualité de vie et la vigilance des travailleurs.
Démographie des chirurgiens-dentistes en région Centre-Val de Loire : opportunités et perspectives
Authors: Denis Frédéric , Guimelli Bernard , Nicolas Emmanuel , Meymandi-Nejad Bruno , de Fontagalland Charlotte , Diot Patrice
Published: January 2020

La région Centre-Val de Loire est particulièrement impactée par la pénurie de professionnels de santé. La démographie des chirurgiens-dentistes n’échappe pas à cette conjoncture au point que le départ à la retraite d’un praticien est devenu un véritable enjeu de santé publique. Pour cela, des passerelles ont été créées entre les facultés d’odontologie de Nantes, de Clermont-Ferrand et la faculté de médecine de Tours, pour accueillir des étudiants de troisième cycle court en région Centre-Val de Loire, faire le lien avec les praticiens libéraux et permettre aux étudiants de se confronter aux problématiques de santé de ce territoire.
OPTOGENETICA: CONTROLLARE I NEURONI CON LA LUCE
Authors: Moroni Anna
Published: January 2020

Optogenetics is a booming technique in neuroscience that allows manipualtion of neuronal activity by light. Neuronal activation can be achieved by the activation of light-gated cation channels while neuronal inhibition relies on the activation of chloride pumps and channels. We have engineered a light-gated potassium (K+) channel (BLINK) by linking the plant photoreceptor module LOV2 to the viral channel Kcv. Upon illumination with blue light (450 nm), BLINK channel hyperpolarizes neurons to EK and this effect persists for several minutes even in the dark. Pilot experiments in a mouse pain model show that this protracted light-off activity can be successfully employed for long term pain relief after activation of the channel by a short pulse of light.
Spirit baptism and the doctrine of initial evidence in African Pentecostal Christianity: A critical analysis
Authors: Kgatle Mookgo S.
Published: January 2020

Pentecostalism is known for the belief in Spirit baptism that is accompanied by the doctrine of initial evidence, that is, speaking in tongues. The practice of the doctrine of initial evidence has become a unique feature of Pentecostalism for many years since its beginning. Similarly, Spirit baptism and the doctrine of initial evidence are practised in African Pentecostal Christianity, especially in classical Pentecostal churches and charismatic movements. However, there are challenges with this doctrine: speaking in tongues is perceived as the only evidence, and there is an emphasis on gifts than fruit of the Holy Spirit and a great emphasis on public spiritual experiences than personal encounters with God. In re-imagining the doctrine of initial evidence in African Pentecostal Christianity, speaking in tongues should not be emphasised or practised as the only evidence of Spirit baptism because there are other evidences that demonstrate the baptism in the Holy Spirit. The emphasis should be on prayer than the speaking of tongues. In addition, priority should be given to the fruit of the Spirit and on a personal encounter with God. Finally, speaking in tongues should be accompanied by interpretation in a public service because the public cannot understand the language.
Limiting Properties of the Distribution of Primes in an Arbitrarily Large Number of Residue Classes
Authors: Devin Lucile
Published: January 2020

We generalize current known distribution results on Shanks–Rényi prime number races to the case where arbitrarily many residue classes are involved. Our method handles both the classical case that goes back to Chebyshev and function field analogues developed in the recent years. More precisely, let $\unicode[STIX]{x1D70B}(x;q,a)$ be the number of primes up to $x$ that are congruent to $a$ modulo $q$. For a fixed integer $q$ and distinct invertible congruence classes $a_{0},a_{1},\ldots ,a_{D}$, assuming the generalized Riemann Hypothesis and a weak version of the linear independence hypothesis, we show that the set of real $x$ for which the inequalities $\unicode[STIX]{x1D70B}(x;q,a_{0})>\unicode[STIX]{x1D70B}(x;q,a_{1})>\cdots >\unicode[STIX]{x1D70B}(x;q,a_{D})$ are simultaneously satisfied admits a logarithmic density.