bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Temperature and pH on Immobilized Laccase Activity in Conjugated Methacrylate-Acrylate Microspheres
Authors: Mazlan Siti Zulaikha , Hanifah Sharina Abu
Published: October 2017

Immobilization of laccase on the functionalized methacrylate-acrylate copolymer microspheres was studied. Poly(glycidyl methacrylate-co-n-butyl acrylate) microspheres consisting of epoxy groups were synthesized using facile emulsion photocuring technique. The epoxy groups in poly(GMA-co-nBA) microspheres were then converted to amino groups. Laccase immobilization is based on covalent binding via amino groups on the enzyme surface and aldehyde group on the microspheres. The FTIR spectra showed peak at 1646 cm−1 assigned to the conformation of the polymerization that referred to GMA and nBA monomers, respectively. After modification of the polymer, intensity of FTIR peaks assigned to the epoxy ring at 844 cm−1 and 904 cm−1 was decreased. The results obtained from FTIR exhibit a good agreement with the epoxy content method. The activity of laccase-immobilized microspheres increased upon increasing the epoxy content. Furthermore, poly(GMA-co-nBA) microspheres revealed uniform size below 2 µm that contributes to large surface area of the microspheres to be used as a matrix, thus increasing the enzyme capacity and enzymatic reaction. Immobilized enzyme also shifted to higher pH and temperature compared to free enzyme.
Evaluation of CO2-Fluid-Rock Interaction in Enhanced Geothermal Systems: Field-Scale Geochemical Simulations
Authors: Pan Feng , McPherson Brian J. , Kaszuba John
Published: October 2017

Recent studies suggest that using supercritical CO2 (scCO2) instead of water as a heat transmission fluid in Enhanced Geothermal Systems (EGS) may improve energy extraction. While CO2-fluid-rock interactions at “typical” temperatures and pressures of subsurface reservoirs are fairly well known, such understanding for the elevated conditions of EGS is relatively unresolved. Geochemical impacts of CO2 as a working fluid (“CO2-EGS”) compared to those for water as a working fluid (H2O-EGS) are needed. The primary objectives of this study are (1) constraining geochemical processes associated with CO2-fluid-rock interactions under the high pressures and temperatures of a typical CO2-EGS site and (2) comparing geochemical impacts of CO2-EGS to geochemical impacts of H2O-EGS. The St. John’s Dome CO2-EGS research site in Arizona was adopted as a case study. A 3D model of the site was developed. Net heat extraction and mass flow production rates for CO2-EGS were larger compared to H2O-EGS, suggesting that using scCO2 as a working fluid may enhance EGS heat extraction. More aqueous CO2 accumulates within upper- and lower-lying layers than in the injection/production layers, reducing pH values and leading to increased dissolution and precipitation of minerals in those upper and lower layers. Dissolution of oligoclase for water as a working fluid shows smaller magnitude in rates and different distributions in profile than those for scCO2 as a working fluid. It indicates that geochemical processes of scCO2-rock interaction have significant effects on mineral dissolution and precipitation in magnitudes and distributions.
The Evidence of Cooperative Binding of a Ligand to G4 DNA
Authors: Kudrev A. G.
Published: October 2017

Intrinsic constants of the ligand binding with G4 DNA (guanine-rich DNA sequence) using quantitative standards can be convenient providing the assessment for elucidating the possibility of such structures participation in biochemical processes. In the present communication, the hard + soft modelling approach to calculate intrinsic constants of a ligand binding with short DNA molecule, particularly such as G4 DNA, has been proposed. The suggested approach has focused upon the quantitative evaluating of a mutual influence between sites and between bound ligands. The cross-validation between a new hard + soft modelling and conventional stepwise complex formation algorithm has been conducted. A number of simulated examples will illustrate the methodology. The experimental mole-ratio titration of TMPyP4 by G4 DNA [(CG3)2CGC(AG3)2G] has been reexamined. The [(CG3)2CGC(AG3)2G] that folds from a G-rich sequence found in the promoter region of c-kit oncogene can be considered as a molecule with two equivalent mutually influence binding sites.
Adaptive Neural Network Control for Nonlinear Hydraulic Servo-System with Time-Varying State Constraints
Authors: Lu Shu-Min , Li Dong-Juan
Published: October 2017

An adaptive neural network control problem is addressed for a class of nonlinear hydraulic servo-systems with time-varying state constraints. In view of the low precision problem of the traditional hydraulic servo-system which is caused by the tracking errors surpassing appropriate bound, the previous works have shown that the constraint for the system is a good way to solve the low precision problem. Meanwhile, compared with constant constraints, the time-varying state constraints are more general in the actual systems. Therefore, when the states of the system are forced to obey bounded time-varying constraint conditions, the high precision tracking performance of the system can be easily realized. In order to achieve this goal, the time-varying barrier Lyapunov function (TVBLF) is used to prevent the states from violating time-varying constraints. By the backstepping design, the adaptive controller will be obtained. A radial basis function neural network (RBFNN) is used to estimate the uncertainties. Based on analyzing the stability of the hydraulic servo-system, we show that the error signals are bounded in the compacts sets; the time-varying state constrains are never violated and all singles of the hydraulic servo-system are bounded. The simulation and experimental results show that the tracking accuracy of system is improved and the controller has fast tracking ability and strong robustness.
The Asymptotic Behaviours of a Class of Neutral Delay Fractional-Order Pantograph Differential Equations
Authors: Miao Baojun , Li Xuechen
Published: October 2017

By using fractional calculus and the summation by parts formula in this paper, the asymptotic behaviours of solutions of nonlinear neutral fractional delay pantograph equations with continuous arguments are investigated. The asymptotic estimates of solutions for the equation are obtained, which may imply asymptotic stability of solutions. In the end, a particular case is provided to illustrate the main result and the speed of the convergence of the obtained solutions.
Research on the Field Dynamic Balance Technologies for Large Diesel Engine Crankshaft System
Authors: Zhang Shihai , Zhang Zimiao
Published: October 2017

In order to reduce the unbalancing mass and the accompanying unbalancing vibration of diesel engine crankshaft system, the field dynamic balancing method and its key technologies are presented in the paper. In order to separate the unbalancing vibration signal from the total vibration signal of crankshaft system, the fundamental frequency signal fitting principle based on the least square method was introduced firstly, and then wavelet noise reduction method was applied to improve the signal fitting precision of least square method. Based on the unbalancing vibration signal analysis and assessment of crankshaft system, the influence coefficient method was applied to calculate the value and phase of the equivalent unbalancing mass in flywheel. To easily correct the unbalancing condition of crankshaft system, the unbalancing adjustment equipment was designed based on the flywheel structure. The balancing effect of field dynamic balancing system designed for the large diesel engine has been verified by field experiments.
Complex Dynamics and Chaos Control on a Kind of Bertrand Duopoly Game Model considering R&D Activities
Authors: Tu Hongliang , Zhan Xueli , Mao Xiaobing
Published: October 2017

We study a dynamic research and development two-stage input competition game model in the Bertrand duopoly oligopoly market with spillover effects on cost reduction. We investigate the stability of the Nash equilibrium point and local stable conditions and stability region of the Nash equilibrium point by the bifurcation theory. The complex dynamic behaviors of the system are shown by numerical simulations. It is demonstrated that chaos occurs for a range of managerial policies, and the associated unpredictability is solely due to the dynamics of the interaction. We show that the straight line stabilization method is the appropriate management measure to control the chaos.
The Impact of Diagnostic Code Misclassification on Optimizing the Experimental Design of Genetic Association Studies
Authors: Schrodi Steven J.
Published: October 2017

Diagnostic codes within electronic health record systems can vary widely in accuracy. It has been noted that the number of instances of a particular diagnostic code monotonically increases with the accuracy of disease phenotype classification. As a growing number of health system databases become linked with genomic data, it is critically important to understand the effect of this misclassification on the power of genetic association studies. Here, I investigate the impact of this diagnostic code misclassification on the power of genetic association studies with the aim to better inform experimental designs using health informatics data. The trade-off between (i) reduced misclassification rates from utilizing additional instances of a diagnostic code per individual and (ii) the resulting smaller sample size is explored, and general rules are presented to improve experimental designs.
Δ9-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic Wistar-Kyoto Rats
Authors: Vella Rebecca K. , Jackson Douglas J. , Fenning Andrew S.
Published: October 2017

The aim of this study was to determine if chronic, low-dose administration of a nonspecific cannabinoid receptor agonist could provide cardioprotective effects in a model of type I diabetes mellitus. Diabetes was induced in eight-week-old male Wistar-Kyoto rats via a single intravenous dose of streptozotocin (65 mg kg−1). Following the induction of diabetes, Δ9-tetrahydrocannabinol was administered via intraperitoneal injection (0.15 mg kg−1 day−1) for an eight-week period until the animals reached sixteen weeks of age. Upon completion of the treatment regime, assessments of vascular reactivity and left ventricular function and electrophysiology were made, as were serum markers of oxidative stress and lipid peroxidation. Δ9-Tetrahydrocannabinol administration to diabetic animals significantly reduced blood glucose concentrations and attenuated pathological changes in serum markers of oxidative stress and lipid peroxidation. Positive changes to biochemical indices in diabetic animals conferred improvements in myocardial and vascular function. This study demonstrates that chronic, low-dose administration of Δ9-tetrahydrocannabinol can elicit antihyperglycaemic and antioxidant effects in diabetic animals, leading to improvements in end organ function of the cardiovascular system. Implications from this study suggest that cannabinoid receptors may be a potential new target for the treatment of diabetes-induced cardiovascular disease.
Contamination of Soil with Pb and Sb at a Lead-Acid Battery Dumpsite and Their Potential Early Uptake by Phragmites australis
Authors: Jera Abraham , Ncube France , Kanda Artwell
Published: October 2017

Recycling of spent Lead-Acid Batteries (LABs) and disposal of process slag potentially contaminate soil with Pb and Sb. Total and available concentrations of Pb and Sb in three soil treatments and parts of Phragmites australis were determined by atomic absorption spectrophotometry. Soil with nonrecycled slag (NR) had higher total metal concentrations than that with recycled slag (RS). Low available fractions of Pb and Sb were found in the soil treatments before planting P. australis. After 16 weeks of growth of P. australis, the available fractions of Pb had no statistical difference from initial values (p>0.05) while available Sb fractions were significantly lower when compared with their initial values (p<0.05). Metal transfer factors showed that P. australis poorly accumulate Pb and Sb in roots and very poorly translocate them to leaves after growing for 8 and 16 weeks. It may be a poor phytoextractor of Pb and Sb in metal-contaminated soil at least for the 16 weeks of its initial growth. However, the plant established itself on the metalliferous site where all vegetation had been destroyed. This could be useful for potential ecological restoration. The long-term phytoextraction potential of P. australis in such environments as LABs may need further investigation.
Enhanced Optical and Electrical Properties of ITO/Ag/AZO Transparent Conductors for Photoelectric Applications
Authors: Lee Gyeong-Nam , M. Ponnamma Machaiah , Park Wang-Hee , Kim Joondong
Published: October 2017

The enhancement of the optical and electrical properties of TCO films was investigated by depositing different layers of AZO (100 nm), Ag (5 nm)/AZO (95 nm), and ITO (45 nm)/Ag (5 nm)/AZO (50 nm) upon n-Si substrate at room temperature by magnetron sputtering method. The ITO/Ag/AZO device efficiently improved the electrical and optical properties with the low sheet resistance of 2.847 Ω/sq. and an increase in the rectification ratio of 455.60% when compared with AZO and Ag/AZO devices. The combination of ITO/Ag/AZO provided the optimum results in all the electrical and optical properties. These results showed that within the optimized thickness range of 100 nm, compared to AZO and Ag/AZO, ITO/Ag/AZO device showed the improvement for both optical and electrical properties at room temperature.
Effects of Whole‐Body Electromyostimulation on Low Back Pain in People with Chronic Unspecific Dorsal Pain: A Meta‐Analysis of Individual Patient Data from Randomized Controlled WB‐EMS Trials
Authors: Kemmler Wolfgang , Weissenfels Anja , Bebenek Michael , Fröhlich Michael , Kleinöder Heinz , Kohl Matthias , von Stengel Simon
Published: October 2017

In order to evaluate the favorable effect of whole‐body electromyostimulation (WB‐EMS) on low back pain (LBP), an aspect which is frequently claimed by commercial providers, we performed a meta‐analysis of individual patient data. The analysis is based on five of our recently conducted randomized controlled WB‐EMS trials with adults 60 years+, all of which applied similar WB‐EMS protocols (1.5 sessions/week, bipolar current, 16–25 min/session, 85 Hz, 350 μs, and 4–6 s impulse/4 s impulse‐break) and used the same pain questionnaire. From these underlying trials, we included only subjects with frequent‐chronic LBP in the present meta‐analysis. Study endpoints were pain intensity and frequency at the lumbar spine. In summary, 23 participants of the underlying WB‐EMS and 22 subjects of the control groups (CG) were pooled in a joint WB‐EMS and CG. At baseline, no group differences with respect to LBP intensity and frequency were observed. Pain intensity improved significantly in the WB‐EMS (p < .001) and was maintained (p = .997) in the CG. LBP frequency decreased significantly in the WB‐EMS (p < .001) and improved nonsignificantly in the CG (p = .057). Group differences for both LBP parameters were significant (p ≤ .035). We concluded that WB‐EMS appears to be an effective training tool for reducing LBP; however, RCTs should further address this issue with more specified study protocols.
Quantum-Dot and Polychalcone Mixed Nanocomposites for Polymer Light-Emitting Diodes
Authors: Ramkumar Vanaraj , Ju Sanghyun
Published: October 2017

The present work is aimed at improving the efficiency of light-emitting diodes (LEDs) through the amalgamation of polymeric materials and quantum dots (QDs) in nanocomposites. Herein, we report on the polytriphenylamine-based chalcone (PTpC) or polycarbazole-based chalcone- (PCzC-) QDs mixture nanocomposites as emissive layers for polymer LEDs (PLEDs). QDs were evenly dispersed in the polymer matrix and the synthesized PTpC-QDs and PCzC-QDs nanocomposites were able to form smooth thin films. The luminance characteristics of PTpC-QDs and PCzC-QDs nanocomposites were better than those of the pristine QD, PTpC, and PCzC materials, owing to the high charge-carrier transport ability of polymer-QDs nanocomposites. These results indicate that the proposed polymer-QDs nanocomposites could be potential candidates for application in PLEDs.
A Case of Invasive Pneumococcal Infection with Septic Shock and Rare Complications
Authors: Woytanowski John R. , Hakim Nausheen , Deering Caytlin , Schultz Sara
Published: October 2017

Invasive pneumococcus is a serious illness with potentially devastating outcomes. A 64-year-old female with a medical history of psoriatic arthritis and diabetes was transferred from an outside hospital for ventilator dependent respiratory failure and altered mental status. She initially presented with worsening back pain and was found to have leukocytosis with bandemia and acute renal failure but she was in septic shock upon arrival to our tertiary care center. Her blood cultures grew Streptococcus pneumoniae and MRI of the brain revealed pus within the posterior lateral ventricles and multiple infarcts. MRI of the spine revealed a psoas abscess. Transesophageal echocardiogram revealed mitral valve vegetation and her right eye developed endogenous endophthalmitis. She was treated with intravenous and intravitreal antibiotics and underwent drainage of the abscess with no improvement in mental status. Repeat imaging revealed multiple new thalamic, basal ganglia, and parietal lobe infarcts likely from septic emboli. After a protracted ICU stay, the patient’s family opted for comfort care. The incidence of invasive pneumococcal infections has declined rapidly since the advent of antibiotics and vaccines. With the growing incidence of antibiotic resistance as well as the emergence of new immunomodulating drugs for various pathologies, there is a concern that invasive infections will reemerge. Ventriculitis and endogenous endophthalmitis are very rare complications of pneumococcal bacteremia.
Comparison of Simulated Drift Rates of Common ALS-Inhibiting Rice Herbicides to Florpyrauxifen-Benzyl on Soybean
Authors: Schwartz-Lazaro Lauren M. , Miller M. Ryan , Norsworthy Jason K. , Scott Robert C.
Published: October 2017

Acetolactate synthase- (ALS-) herbicides are among the most commonly used sites of action (SOA) in rice production. Many herbicides used in rice can cause carryover to soybean, which is commonly grown near to or rotated with rice. Florpyrauxifen-benzyl (Rinskor™ Active) brings an alternative SOA to rice production. The objective of this study was to compare the effects of simulated drift rates of florpyrauxifen-benzyl to commonly used ALS-inhibiting rice herbicides on soybean. A field study was conducted at two locations examining five ALS-inhibiting rice herbicides as well as florpyrauxifen-benzyl at a 1/20x and 1/80x simulated drift rate. Crop injury, height, and yield were evaluated at 14, 21, and 35 days after treatment (DAT). Florpyrauxifen-benzyl and bispyribac showed high injury levels at both drift rates. At 35 DAT florpyrauxifen-benzyl caused 76% and 17% visible damage to soybean whereas bispyribac caused 35 and 9% injury at 1/20x and 1/80x, respectively. These treatments resulted in a reduction in soybean height and yield. Although this alternative SOA herbicide in rice may be effective for weed control, our research demonstrates it to be injurious to soybean at both drift rates tested. Thus, proper precautions should be taken to avoid injury by ensuring that the label is followed.
RUNX1 Upregulation by Cytotoxic Drugs Promotes Apoptosis
Authors: Speidel Daniel , Wellbrock Jasmin , Abas Melissa
Published: October 2017

Mutations in the RUNX1 gene have been associated with chemotherapy resistance and poor prognosis in patients with acute myeloid leukemia (AML), T-cell acute lymphoblastic leukemia, and myelodysplastic syndromes. However, the underlying mechanisms connecting RUNX1 to the success of therapy remain elusive. Here we explore the hypothesis that RUNX1 is directly involved in the response of hematopoietic cells to cytotoxic agents. RUNX1 was upregulated posttranscriptionally by cytotoxic agents in C57BL/6 mice in vivo and hematopoietic cell lines. Upregulation was also seen in primary human AML cells after treatment with cytarabine in vitro. Upon overexpression, RUNX1 restricted proliferation, promoted apoptosis, and augmented the DNA damage response. This unknown activity of RUNX1 required an intact runt homology domain (RHD), a domain where most leukemia-associated point mutations cluster. Consistent with this, two RHD-defective RUNX1 proteins lacked any antiproliferative or apoptotic activity, and RHD-defective (K83N, N109D) mutant RUNX1 conferred resistance to ionizing radiation when overexpressed in Ba/F3 cells under certain conditions. Our experiments reveal a novel function of RUNX1 and offer an explanation for the link between RUNX1 mutations and chemotherapy and radiation resistance. Moreover, these data suggest that pharmacologic modulation of RUNX1 might be an attractive new approach to treat hematologic malignancies. Cancer Res; 77(24); 6818–24. ©2017 AACR.
Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence
Authors: Sharma Chandan , Wang Hong-Xing , Li Qinglin , Knoblich Konstantin , Reisenbichler Emily S. , Richardson Andrea L. , Hemler Martin E.
Published: October 2017

DHHC-type protein acyltransferases may regulate the localization, stability, and/or activity of their substrates. In this study, we show that the protein palmitoyltransferase DHHC3 is upregulated in malignant and metastatic human breast cancer. Elevated expression of DHHC3 correlated with diminished patient survival in breast cancer and six other human cancer types. ZDHHC3 ablation in human MDA-MB-231 mammary tumor cell xenografts reduced the sizes of both the primary tumor and metastatic lung colonies. Gene array data and fluorescence dye assays documented increased oxidative stress and senescence in ZDHHC3-ablated cells. ZDHHC3-ablated tumors also showed enhanced recruitment of innate immune cells (antitumor macrophages, natural killer cells) associated with clearance of senescent tumors. These antitumor effects were reversed upon reconstitution with wild-type, but not enzyme-active site-deficient DHHC3. Concomitant ablation of the upregulated oxidative stress protein TXNIP substantially negated the effects of ZDHHC3 depletion on oxidative stress and senescence. Diminished DHHC3-dependent palmitoylation of ERGIC3 protein likely played a key role in TXNIP upregulation. In conclusion, DHHC3-mediated protein palmitoylation supports breast tumor growth by modulating cellular oxidative stress and senescence. Cancer Res; 77(24); 6880–90. ©2017 AACR.
Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol
Authors: Pearson Hannah E. , Iida Mari , Orbuch Rachel A. , McDaniel Nellie K. , Nickel Kwangok P. , Kimple Randall J. , Arbiser Jack L. , Wheeler Deric L.
Published: October 2017

Overexpression and activation of the EGFR have been linked to poor prognosis in several human cancers. Cetuximab is a mAb against EGFR that is used for the treatment in head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer. Unfortunately, most tumors have intrinsic or will acquire resistance to cetuximab during the course of therapy. Honokiol is a natural compound found in the bark and leaves of the Chinese Magnolia tree and is established to have several anticancer properties without appreciable toxicity. In this study, we hypothesized that combining cetuximab and honokiol treatments could overcome acquired resistance to cetuximab. We previously developed a model of acquired resistance to cetuximab in non–small cell lung cancer H226 cell line. Treatment of cetuximab-resistant clones with honokiol and cetuximab resulted in a robust antiproliferative response. Immunoblot analysis revealed the HER family and their signaling pathways were downregulated after combination treatment, most notably the proliferation (MAPK) and survival (AKT) pathways. In addition, we found a decrease in phosphorylation of DRP1 and reactive oxygen species after combination treatment in cetuximab-resistant clones, which may signify a change in mitochondrial function. Furthermore, we utilized cetuximab-resistant HNSCC patient-derived xenografts (PDX) to test the benefit of combinatorial treatment in vivo. There was significant growth delay in PDX tumors after combination treatment with a subsequent downregulation of active MAPK, AKT, and DRP1 signaling as seen in vitro. Collectively, these data suggest that honokiol is a promising natural compound in overcoming acquired resistance to cetuximab. Mol Cancer Ther; 17(1); 204–14. ©2017 AACR.
Incorporating CDK4/6 Inhibitors in the Treatment of Advanced Luminal Breast Cancer
Authors: Echavarria Isabel , Jerez Yolanda , Martin Miguel , López-Tarruella Sara
Published: October 2017

After optimizing endocrine monotherapy modalities in the setting of advanced luminal breast cancer (BC), dual endocrine/targeted therapy combinations have been tested with positive results, and are transforming this BC subtype treatment landscape. Cell cycle deregulation is a hallmark of cancer that has become a key druggable target in hormone receptor (HR)-positive BC due to its role in endocrine resistance mechanisms. Cyclin dependent kinase (CDK)4/6 inhibitors have experienced a fast development in combination with endocrine therapy and have already been commercialized in some countries. In this review, we will summarize the development of these CDK4/6 inhibitors in luminal BC, from the preclinical data to the pivotal phase III trials that led to their approval, focusing on the efficacy and safety data for each of the treatment settings. Moreover, we will consider the challenges CDK4/6 inhibitors face in their positioning in the algorithm of treatment for advanced luminal BC and the considerations physicians should take into account when selecting these therapies for their patients. However, we are still in need of reliable predictive biomarkers in order to identify patients who will derive the greatest benefit from these drug combinations that are not exempt from toxicity.
Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases
Authors: Garofalo Virginia , Ventura Alessandra , Mazzilli Sara , Diluvio Laura , Bianchi Luca , Toti Luca , Tisone Giuseppe , Milani Massimo , Campione Elena
Published: October 2017

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers. Topical application of cyclooxygenase inhibitors such as diclofenac and, more recently, piroxicam has shown to reduce AK lesions in immunocompetent subjects. A medical device containing piroxicam and SPF 50+ sunscreen filters (P+SS) has been demonstrated to be effective in reducing AK lesions and improving the field of cancerization. We report the effect of P+SS, applied for 16 weeks, in a case series of 10 OTR subjects with multiple AK lesions. P+SS treatment was associated with a relevant AK lesion reduction (>75%) in 7 patients (with a complete clearance in 3 subjects) with an improvement in the field of cancerization. This medical device could be considered a promising long-term curative and preventive treatment in OTR patients at high risk of non-melanoma skin cancers.
Anti-Diabetic Potential of the Leaves of Anisomeles malabarica in Streptozotocin Induced Diabetic Rats
Authors: Kotha Peddanna , Badri Kameswara Rao , Nagalapuram Ramya , Allagadda Rajasekhar , Chippada Appa Rao
Published: October 2017

Background/Aims: Diabetes mellitus is a pandemic metabolic disorder that is affecting a majority of populations in recent years. There is a requirement for new drugs that are safer and cheaper due to the side effects associated with the available medications. Methods: We investigated the anti-diabetic activity of leaves of Anisomeles malabarica following bioactivity guided fractionation. The different solvent (hexane, ethyl acetate, methanol and water) extracts of A. malabarica leaves were used in acute treatment studies to evaluate and identify the active fraction. The ethyl acetate extract was subjected to further fractionation using silica gel column chromatography and the compounds were identified by LC-SRM/MS and GC-MS. Additional chronic treatment studies were carried out using this active fraction (AMAF) for 30 days in experimental diabetic rats. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), plasma insulin levels and glucose tolerance were measured along with insulin resistance/sensitivity indicators (HOMA-IR, HOMA-β and QUICKI) to assess the beneficial effects of A. malabarica in the management of diabetes mellitus. Results: Among the different solvent extracts tested, ethyl acetate extract showed maximum (66%) anti-hyperglycemic activity. The hexane and ethyl acetate (1: 1) fraction that has maximum anti-diabetic activity was identified as active fraction of A. malabarica (AMAF). The FBG, HbA1c, plasma insulin levels and insulin sensitivity/resistance indicators such as glucose tolerance, HOMA-IR, HOMA-β and QUICKI were significantly improved to near normal in diabetic rats treated with AMAF. Further, we identified key flavonoids and fatty acids as the anti-diabetic active principles from the AMAF of A. malabarica leaves. Conclusion: The results of our study suggest that Anisomeles malabarica has potential anti-diabetic activity in STZ induced diabetic rats.
Patient satisfaction with pharmaceutical services in Brazilian primary health care
Authors: Soeiro Orlando Mario , Tavares Noêmia Urruth Leão , Nascimento Júnior José Miguel do , Guerra Junior Augusto Afonso , Costa Ediná Alves , Acurcio Francisco de Assis , Guibu Ione Aquemi , Álvares Juliana , Karnikowski Margô Gomes de Oliveira , Leite Silvana Nair , Costa Karen Sarmento
Published: October 2017

OBJECTIVE: To evaluate patient satisfaction with pharmaceutical services in Brazilian primary health care. METHODS: This is a cross-sectional, exploratory, and evaluative study on a representative sample from the five Brazilian geopolitical regions resulting from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos – Serviços, 2015 (PNAUM – National Survey on Access, Use and Promotion of Rational Use of Medicines – Services, 2015). The outcome was the patient’s satisfaction, obtained using the item response theory. Associations were tested using Pearson’s Chi-square test with sociodemographic and health variables, and multiple logistic regression analyses were carried out. The Hosmer-Lemeshow test was used to verify the adequacy of the final model. Logistic regression results were presented as odds ratio. RESULTS: The overall percentage of patients satisfied with these services was 58.4% (95%CI 54.4-62.3). The “opportunity/convenience” aspect had the lowest satisfaction percentage (49.5%; 95%CI 46.4-52.6) and “interpersonal aspects,” the highest percentage (90.5%; 95%CI 88.9-91.8), significantly higher than other aspects. Sex, age group, limitations due to disease, and self-perception of health remained associated in the final multiple logistic model regarding general satisfaction. CONCLUSIONS: Most of the interviewed users were satisfied with pharmaceutical services in Brazilian cities, and the satisfaction with the customer’s service was determinant in the patient’s overall satisfaction
Mitral Leaflet Changes Following Myocardial Infarction
Authors: Beaudoin Jonathan , Dal-Bianco Jacob P. , Aikawa Elena , Bischoff Joyce , Guerrero J. Luis , Sullivan Suzanne , Bartko Philipp Emanuel , Handschumacher Mark D. , Kim Dae-Hee , Wylie-Sears Jill , Aaron Jacob , Levine Robert A.
Published: October 2017

Background—

Ischemic mitral regurgitation (MR) is classically ascribed to functional restriction of normal leaflets, but recent studies have suggested post–myocardial infarction (MI) mitral valve (MV) leaflet fibrosis and thickening, challenging valve normality. Progression of leaflet thickness post-MI has not been studied. We hypothesized that excessive MV remodeling post-MI contributes to MR. Our objectives are to characterize MV changes after MI and relate them to MR.

Methods and Results—

Three groups of 40 patients with serial echocardiograms over a mean of 23.4 months were identified from an echocardiography database: patients first studied early (6±12 days) and late (12±7 years) after an inferior MI and normal controls. MV thickness was correlated with MR. We studied the mechanisms for MV changes in a sheep model (6 apical MI versus 6 controls) followed for 8 weeks, with MV cellular and histopathologic analyses. Early post-MI, leaflet thickness was found to be similar to controls (2.6±0.5 vs 2.5±0.4 mm;
P
=0.23) but significantly increased over time (2.5±0.4 to 2.9±0.4 mm;
P
<0.01). In this group, patients tolerating maximal doses of renin–angiotensin blocking agents had less thickening (25% of patients;
P
<0.01). The late-MI group had increased thickness (3.2±0.5 vs 2.5±0.4 mm;
P
<0.01) without progression. At follow-up, 48% of post-MI patients had more than mild MR. Increased thickness was independently associated with MR. Experimentally, 8 weeks post-MI, MVs were 2-fold thicker than controls, with increased collagen, profibrotic transforming growth factor-β, and endothelial-to-mesenchymal transformation, confirmed by flow cytometry.

Conclusions—

MV thickness increases post-MI and correlates with MR, suggesting an organic component to ischemic MR. MV fibrotic remodeling can indicate directions for future therapy.
The Biblical Hebrew “Store Cities” and an Amarna Gloss
Authors: Baranowski Krzysztof J.
Published: October 2017

The word מסכנות used in the phrase ערי מסכנות “store cities” is commonly considered a loanword from the Neo-Assyrian word maškattu, “account, deposit, storehouse.” The current loan hypothesis does not account for the difficulties of the Akkadian evidence and does not take into consideration a gloss in Amarna letter no. 306. This gloss shows that the Canaanite scribes of the Late Bronze Age were familiar with the Akkadian plural form maškanātu and used it with the meaning “granaries, storage areas.” This technical term was borrowed into a Canaanite dialect and was subsequently transmitted to Biblical Hebrew as מסכנות.
Separation and Creation in Genesis 1 and Psalm 104, A Continuation of the Discussion of the Verb ברא
Authors: van Wolde Ellen
Published: October 2017

The meaning of the verb ברא is the subject of fierce discussions. Conventionally it has been rendered by biblicists and Hebraists as “to create,” but this traditional interpretation fails to explain adequately numerous linguistic and conceptual aspects of the verb’s usage. Historical solutions of these problems are discussed. The alternative hypothesis defended here is that the verb ברא Qal designates “to separate.” It is considered to be a spatial concept, not a concept that figures in the domain of construction. In the present article I present further analyses of the verb ברא in Gen 1 and explain the significance for the idea of creation it represents, and of the most famous creation psalm, Ps 104, and especially of vv. 26-30 in which the term ברא is used. The similarities and dissimilarities between these two texts demonstrate that each context of usage of ברא must be independently investigated and appreciated.
On the Frontier between Eastern and Western Yiddish: Sources from Burgenland
Authors: Schäfer Lea
Published: October 2017

Burgenland, the smallest state of current Austria, located on the border with Hungary, once had seven vibrant Jewish communities under the protection of the Hungarian Eszterházy family. There is next to nothing known about the Yiddish variety spoken in these communities. This article brings together every single piece of evidence of this language to get an impression of its structure. This article shows that Yiddish from Burgenland can be integrated into the continuum between Eastern and Western Yiddish and is part of a gradual transition zone between these two main varieties.
A new species of Angaeus from Malaysia with possible affinity to related genera within Stephanopinae (Araneae: Thomisidae)
Authors: BENJAMIN SURESH P.
Published: October 2017

The crab spider genus Angaeus Thorell, 1881 currently contains 10 described species (Benjamin 2013; WSC 2017). All species of the genus are restricted to tropical Asia. The aim of this correspondence is to illustrate and describe a new species of the genus characterized by a number of features previously found in the genera Angaeus, Borboropactus Simon, 1884, Epidius Thorell, 1877 and Geraesta Simon, 1889. The most unusual feature is the elongated tibia of the male palp that was previously thought to be diagnostic of Epidius (Figs 1, 2, 8; character 1 in Benjamin 2011; Benjamin 2017). However, the new species lacks tibial macrosetae (Figs 1, 2, 8) and lacks a flexibly attached MA, both also being characteristics of Epidius (characters 2 and 18 in Benjamin 2011). Furthermore, this new species differs considerably in general appearance from all known species of Epidius.
Two new species of Hyalella (Crustacea, Amphipoda, Hyalellidae) from state of Rio Grande do Sul, Southern Brazil
Authors: STRECK MORGANA TAIS , CARDOSO GIOVANNA MONTICELLI , RODRIGUES STELLA GOMES , GRAICHEN DANIEL ANGELO SGANZERLA , CASTIGLIONI DANIELA DA SILVA
Published: October 2017

There are 68 known species of Hyalella worldwide, with 23 occurring in Brazil. The state of Rio Grande do Sul, Southern Brazil, has the largest diversity of the genus in the country, with nine species recorded. The current study aimed to describe two new species of Hyalella from state of Rio Grande do Sul, both of them in the Northwest region of the state, one found in a small spring and another in an artificial pond. Hyalella georginae n. sp. presents several clusters of simple setae on antenna 2, maxilliped very slender, gnathopod 2 dactylus not reaching the lobe of propodus, pleopods rami with short plumose setae and a peculiar pattern of setae on uropods and telson. Hyalella gauchensis n. sp. presents antenna 2 with few setae, maxilliped very slender, gnathopod 2 dactylus reaching the lobe of propodus and pleopods rami with long plumose setae. From this work, the number of Hyalella species found in Brazil increases to 25 and 70 for the genus.
Acculturation and severity of depression among first-generation Vietnamese outpatients in Germany
Authors: Nguyen Main Huong , Hahn Eric , Wingenfeld Katja , Graef-Calliess Iris T , von Poser Anita , Stopsack Malte , Burian Hannah , Dreher Annegret , Wolf Simon , Dettling Michael , Burian Ronald , Diefenbacher Albert , Ta Thi Minh Tam
Published: October 2017

Background:

Challenges of migration, particularly concerning the process of acculturation are associated with an increased risk of mental illness. Vietnamese migrants constitute the largest Southeast Asian migrant group in Germany, yet there is no data on the relationship between the mental health status and acculturation among this population.

Aims:

Therefore, the present study examines the relationship between two well-established dimensions of acculturation, that is, dominant society immersion (DSI) and ethnic society immersion (ESI), the four resulting acculturation strategies (integration, assimilation, separation and marginalization), and severity of depression.

Methods:

A sample of N = 113 first-generation Vietnamese outpatients from a psychiatric outpatient clinic for Vietnamese migrants in Germany was studied regarding their self-reported depressive symptoms (Beck Depression Inventory-II (BDI-II)) and acculturation (Stephenson Multigroup Acculturation Scale (SMAS)).

Results:

Consistent with the hypotheses, patients reported less severe depressive symptoms, when they reported higher orientation toward the German and the Vietnamese society. Moreover, the results showed that integrated patients reported a lower severity of depression compared to marginalized patients, who reported the highest severity of depression.

Conclusions:

The findings indicate that among a sample of first-generation Vietnamese patients with depression, an orientation to both, the mainstream society and one’s heritage society might serve as a potential resource. The rejection of any orientation to any society is associated with an increased risk for depression.
Incorporation of AWS 316L wire nanostructured with nickel-carbon nanotube by arc welding
Authors: Loayza Cristhian RL , Assunção Paulo DC , Cardoso Danyella CS , Borges Diego JA , Filho Ademir AC , Reis Marcos AL , Braga Eduardo M
Published: October 2017

Carbon nanotubes have certain properties, such as 150 GPa tensile strength, a 1000 GPa shear modulus, an electrical conductivity of 60 S/m, and a high thermal conductivity of 2500 W/mk, that make them an optimum metallic matrix composite reinforcement. Otherwise, arc welding is a common industrial process that joins almost all metals. However, there are hardly any studies involving the addition of carbon nanotubes in stainless steel so far. In this research, we show the incorporation of an AWS 316L nanostructured wire with nickel-carbon nanotubes in austenitic stainless steel via pulsed gas tungsten arc welding, which formed nanocomposites with 0.75 and 1.5 wt% carbon nanotube contents in the wire. The characterization was performed by scanning electronic microscope, Raman spectroscopy, and X-ray diffraction. The Vickers microhardness test was used to analyze the mechanical properties. The nanostructure composite had microstructure modification, and superficial microhardness improved in 35% for 0.75 wt% carbon nanotube.
Chitosan-Based Trilayer Scaffold for Multitissue Periodontal Regeneration
Authors: Varoni E.M. , Vijayakumar S. , Canciani E. , Cochis A. , De Nardo L. , Lodi G. , Rimondini L. , Cerruti M.
Published: October 2017

Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it requires the simultaneous restoration of different tissues—namely, cementum, gingiva, bone, and periodontal ligament (PDL). Here, we synthetized a chitosan (CH)–based trilayer porous scaffold to achieve periodontal regeneration driven by multitissue simultaneous healing. We produced 2 porous compartments for bone and gingiva regeneration by cross-linking with genipin either medium molecular weight (MMW) or low molecular weight (LMW) CH and freeze-drying the resulting scaffolds. We synthetized a third compartment for PDL regeneration by CH electrochemical deposition; this allowed us to produce highly oriented microchannels of about 450-µm diameter intended to drive PDL fiber growth toward the dental root. In vitro characterization showed rapid equilibrium water content for MMW-CH and LMW-CH compartments (equilibrium water content after 5 min >85%). The MMW-CH compartment degraded more slowly and provided significantly more resistance to compression (28% ± 1% of weight loss at 4 wk; compression modulus HA = 18 ± 6 kPa) than the LMW-CH compartment (34% ± 1%; 7.7 ± 0.8 kPa) as required to match the physiologic healing rates of bone and gingiva and their mechanical properties. More than 90% of all human primary periodontal cell populations tested on the corresponding compartment survived during cytocompatibility tests, showing active cell metabolism in the alkaline phosphatase and collagen deposition assays. In vivo tests showed high biocompatibility in wild-type mice, tissue ingrowth, and vascularization within the scaffold. Using the periodontal ectopic model in nude mice, we preseeded scaffold compartments with human gingival fibroblasts, osteoblasts, and PDL fibroblasts and found a dense mineralized matrix within the MMW-CH region, with weakly mineralized deposits at the dentin interface. Together, these results support this resorbable trilayer scaffold as a promising candidate for periodontal regeneration.
Creating good problems
Authors: Domers Ted
Published: October 2017

At most high schools, the goal is to prepare students to make the leap to a college environment. By contrast, Philadelphia’s G.W. Carver High School of Engineering and Science has decided to create an environment that mirrors the culture and expectations of college so the transition to college won’t seem like a leap at all. Three changes have been most critical: giving students more choice in their course of study, ensuring greater equity in access to high-level classes and electives, and slowing down the typically frenetic pace of high school to give students more time to focus.
Can we talk about race? An interview with Beverly Daniel Tatum
Authors: Richardson Joan
Published: October 2017

Beverly Daniel Tatum, author of Why Are All the Black Kids Sitting Together in the Cafeteria?, talks about race with Kappan editor-in-chief Joan Richardson. Tatum advises more conversations about race and racial identities as a way to bridge the divide between the races. Silence, she says, is not an effective strategy for improving relationships. Silence may actually harm children because, when parents and teachers avoid talking about race, others will fill the gap for them, often with misinformation or negative information.
Learning to lead for racial equity
Authors: Ngounou Gislaine , Gutierrez Nancy
Published: October 2017

If education leaders aspire to confront and undo the severe racial inequities that exist in so many of our schools and school systems, then they will have to create opportunities for teachers and staff to engage in productive discussions about questions that many of them will be reluctant to consider Given how complex and how deeply felt are Americans’ beliefs about race and equity, these topics cannot be addressed effectively through the sorts of occasional one-time workshops that all-too-often pass for professional development in K-12 education.
Arming students against bad information
Authors: Smith Maribeth D.
Published: October 2017

In the age of fake news, teachers in every subject area should redouble their efforts to help students distinguish between credible and deceptive sources of information. The author calls attention to a few key resources, including the CRAAP guidelines developed at California State University, Chico, and promoted by the American Library Association.