bluuebunny/crossref_metadata_2025 huggingface dataset:
THE TECHNOLOGY OF BUILDING A RISK MATRIX IN R
Authors:   Candidate of Economic Sciences, Associate Professor, Financial University under the Government of the Russian Federation, Moscow, Russia, Apal’kova Tamara G. , Levchenko Kirill G. ,   PhD in Physics and Mathematics, Associate Professor, Financial University under the Government of the Russian Federation, Moscow, Russia, Shevchenko Igor A. ,   Master's degree, Financial University under the Government of the Russian Federation, Moscow, Russia
Published: February 2024

The article presents the technology of risk map construction in the open source language R, and discusses its comparative advantages and usefulness for justification of management decisions are considered. The authors highlight the simplicity and universality of the program code as the main advantages of the method.
Побудова туристичних інтернет-порталів з інтуїтивно зрозумілими інтерфейсами
Authors: Барабах Р. Т. , Дуда О. М. , Дуда Х. О. , Кунанець Н. Е. , Машіка Г. В. , Пасічник С. О.
Published: February 2024

Відзначено, що актуальність побудови туристичних інтернет-порталів обумовлена зростанням популярності онлайн-пошуку інформації про подорожі, посиленням конкуренції на ринку туристичних послуг за увагу користувачів. З'ясовано, що останніми роками невпинно зростають вимоги до якості користувацьких інтерфейсів туристичних інформаційних систем, одним з яких є інтернет-портали. Запропоновано інформаційну модель користувацького інтерфейсу туристичного інтернет-порталу. Оскільки, користувачі очікують від туристичних інтернет-порталів інтуїтивно зрозумілих і зручних інтерфейсів, сформовано вимоги до компонент користувацького інтерфейсу, які сприятимуть забезпеченню вимог до критерію "інтуїтивність". Досліджено процеси побудови загальносистемних принципів формування інформаційних моделей користувацьких інтуїтивних інтерфейсів туристичних інтернет-порталів. Виявлено, що побудова інформаційних моделей дає змогу системно подавати та реалізовувати процеси та процедури проєктування інтернет-порталів з врахуванням запитів користувачів щодо суб'єктивних, персоналізованих вимог, які потрібно враховувати при створенні такого класу складних інформаційних систем. Запропонована модель інтуїтивно зрозумілого інтерфейсу допоможе розробникам створювати зручні інтерфейси, які відповідатимуть очікуванням потенційних користувачів. Встановлено, що наявність інтуїтивно зрозумілого інтерфейсу забезпечить інформаційному продукту, яким є достеменно туристичний інтернет-портал, істотні переваги перед конкурентами і дасть змогу залучити більше користувачів. При цьому вони матимуть змогу швидкого пошуку необхідної інформації. Практичним результатом дослідження стало формування туристичного інтернет-порталу, який базуватиметься на використанні актуальних інформаційно-технологічних інновацій, таких як штучний інтелект, віртуальна та доповнена реальність, опрацювання зображень та голосу та ін. Отримані авторами результати можна використати для розроблення нових туристичних інтернет-порталів з інтуїтивно зрозумілими інтерфейсами, а також для підвищення ефективності наявних туристичних інтернет-порталів. Подальші дослідження будуть спрямовані на формування наборів вимог та створення інформаційних моделей користувацьких інтерфейсів туристичних інтернет-порталів, які відповідатимуть іншим критеріям їх оцінювання.
Para um mundo moral
Authors: Paiva Matheus Maciel
Published: February 2024

A proposta do artigo é investigar a compreensão kantiana do estado de natureza, como esta noção se encontra inserida dentro do sistema filosófico de Kant e sua relação com o gênero humano no que se refere à moralidade, que emerge enquanto um dever para sair deste estado pré-jurídico para um estado de direito público. Neste sentido, este movimento de transição, compreendido no sentido de perfectibilidade da espécie humana, é também trabalhado. Para tanto, alguns conceitos devem ser tratados, como por exemplo a noção de mundo, sua ideia, seu ideal e sua significação existenciária, uma vez que permite compreender a extensão do mundo moral kantiano. Assim, o trabalho aproxima, na medida do possível, o pensamento crítico-epistemológico de Kant, com sua doutrina do direito e seu projeto antropológico-pragmático a fim de compreender o móbil da perfectibilidade e do dever moral da espécie humana que caminha, necessariamente, para um estado civil, mesmo que este não seja o ápice do ideal moral.
Para uma razão negra no mundo
Authors: Aragão Diego Miranda
Published: February 2024

A presente pesquisa defende ser a construção de processos não-eurocêntricos acerca da história uma tarefa epistêmica por excelência. Rever a história desde um ponto de vista de colonizados, por exemplo, implica uma refundação epistêmica solapadora das bases filosóficas fundacionais da constituição dos povos dominados. Os objetivos da presente pesquisa residem em investigar as possibilidades e os elementos necessários dessa construção. Para tanto, foi utilizada uma pesquisa teórico-bibliográfica embasada em estudos descoloniais. Como resultados, notaram-se a necessidade e a relevância de um pensamento afrocentrado, conjugando lutas sociais de negros e de negras, para desfazer a dominação epistêmica da europeidade.
Breves notas sobre o problema da filosofia no Brasil a partir do conceito de 'formação'
Authors: Barbosa Montemor Roger Augusto
Published: February 2024

Falar de filosofia no Brasil nos leva, de algum modo, a inseri-la num quadro maior do processo formativo da cultura brasileira. E neste sentido, ao menos segundo Paulo Arantes, temos em Antônio Candido a figura privilegiada para pensarmos a noção de formação no Brasil. De acordo com Arantes, a noção de formação trabalhada por Candido ofereceria uma espécie de modelo que poderia ser extrapolável para se pensar o problema da formação cultural geral - incluindo a filosófica - num país como o Brasil. Além de Candido, outro autor central para problematizar a formação cultural brasileira é Roberto Schwarz, especialmente seu ensaio As ideias fora de lugar, onde procura sistematizar o sentido da transposição de elementos de uma cultura - no caso a europeia -, num país com pressupostos materiais diferentes daqueles em que esta cultura se originou. Sendo assim, a partir do conceito de formação de Candido e de algumas teses do ensaio As ideias fora de lugar, procuramos comentar sobre alguns aspectos e o sentido possível da formação de uma cultura filosófica no Brasil.
A violência como possibilidade real em Benjamin e Schmitt
Authors: Machado Marcos
Published: February 2024

Neste artigo, entrecruzaremos dois pensadores antagônicos: de um lado, o filósofo Walter Benjamin, entrincheirado contra o nazismo; de outro lado, o jurista Carl Schmitt, adepto desse projeto totalitário. Apesar de se situarem em lados opostos da história, nosso objetivo consiste em analisar o desdobramento do termo violência, conforme expresso no texto de Benjamin Crítica da violência e crítica do poder e na obra O conceito do político, de Schmitt. No texto de Benjamin, as ponderações são especificamente acerca dos tipos de violência que eventualmente poder-se-iam se manifestar como legítimas. Além de questionar o porquê de a violência ser tão temida pelo Estado. A constatação do filósofo é que a violência pode exercer dois papéis fundamentais, a saber, o de instituir um novo Direito ou o de preservar o status quo; enquanto que na obra de Schmitt o ato da violência é admitido como uma possibilidade real, sobretudo em decorrência do agrupamento amigo/inimigo, cuja escolha pelo adversário evidencia o caráter decisório do soberano, que além de deflagrar o seu inimigo poderá instaurar o estado de exceção. Há a possibilidade, portanto, de instituir duas faces da violência. Trata-se, então, de analisar em que medida entre os teóricos Benjamin e Schmitt a violência torna-se uma possibilidade real e efetiva da ação política.
Pengaruh Ekspor, Foreign Direct Invesment, dan Utang Luar Negeri terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Budiman Agit , Herdianto Moh. Jajang , Resti Rai
Published: February 2024

The purpose of this study is to see the extent to which the Indonesian government is successful in carrying out international market activities, namely in the form of export activities, foreign direct investment, and foreign debt in influencing Indonesia's economic growth climate as measured based on GDP. This study uses quantitative methods, which are methods used to statistically explain the relationship and influence of exports, foreign direct investment, and foreign debt on economic growth of Indonesia. The data analysis technique used in this study is multiple linear regression analysis with the OLS (ordinary least squares) method as an estimator. The sample used is time series data for 32 years,  from 1990-2022 from data on GDP, exports, foreign direct investment, and foreign debt. The results of data processing using Eviews show that the variables of export, foreign direct investment, and foreign debt have a positive and significant effect on Indonesia's economic growth.Penelitian ini bertujuan untuk melihat sejauh mana pemerintah Indonesia berhasil dalam menjalankan kegiatan pasar internasional yakni berupa kegiatan ekspor, foreign direct investment, dan utang luar negeri dalam mempengaruhi iklim pertumbuhan ekonomi Indonesia yang diukur berdasarkan PDB. Studi ini menggunakan metode kuantitatif, yaitu metode yang digunakan untuk menjelaskan secara statistik hubungan dan pengaruh ekspor, foreign direct investment, dan utang luar negeri terhadap pertumbuhan ekonomi di Indonesia. Teknik analisis data yang digunakan dalam metode ini adalah analisis regresi linear berganda dengan metode OLS (ordinary least squares) sebagai estimator. Sampel yang digunakan adalah data time series selama 32 tahun yakni dari tahun 1990-2022 dari data PDB, ekspor, foreign direct investment,  dan utang luar negeri. Hasil pengolahan data menggunakan Eviews menunjukkan bahwa baik variabel ekspor, foreign direct investment, maupun utang luar negeri memberikan efek yang positif dan signifikan terhadap pertumbuhan ekonomi Indonesia.
Bagaimana Harga, Promosi, dan Kepemilikan Kendaraan Memengaruhi Permintaan Ojek Online di Kalangan Mahasiswa? (Studi Kasus Mahasiswa Universitas Siliwangi)
Authors: Nugraha Alek Surya , Azhari Septian Cahya , Firmansyah Muhamad Ferdy , Nasution Fatimah Zahra
Published: February 2024

This research aims to determine the influence of price, promotion, and vehicle ownership on the demand for online motorcycle taxi services, both individually and collectively. Students of Siliwangi University for the academic period 2021-2022 were the target of our survey in this study, with a total population of 14,150 students, and 100 students were selected as samples. This research utilized the SEM-PLS method. Data were collected through observation, questionnaires, and literature reviews. The results indicate that the individual effects of price and promotion are positive and significant on the demand for online motorcycle taxi services. This means that as prices become more affordable and promotions become more attractive, the demand for online motorcycle taxi services increases. On the other hand, vehicle ownership has a negative and significant impact on the demand for online motorcycle taxi services, suggesting that an increase in vehicle ownership may lead to a decrease in demand for such services. As a recommendation, companies are advised to offer more attractive promotional deals, adjust prices according to regional coverage, and consider the impact of increased vehicle ownership in adjusting their business models.Penelitian ini memiliki tujuan untuk mengetahui bagaimana pengaruh harga, promosi, dan kepemilikan kendaraan terhadap permintaan jasa ojek online baik secara parsial maupun bersama-sama. Mahasiswa universitas Siliwangi periode akademik 2021-2022 menjadi target survei kami dalam penelitian ini dengan total populasi 14.150 mahasiswa dan 100 mahasaiswa menjadi sampel. Penelitian ini menggunakan metode SEM-PLS. Data dikumpulkan melalui observasi, angket, dan review literatur. Hasil penelitian menunjukkan pengaruh harga dan promosi secara individual adalah positif dan signifikan terhadap permintaan layanan ojek online. Artinya, semakin terjangkau harga dan semakin menarik promosinya, permintaan terhadap layanan ojek online meningkat. Di sisi lain, kepemilikan memiliki pengaruh negatif dan signifikan terhadap permintaan layanan ojek online, menunjukkan bahwa peningkatan jumlah kepemilikan kendaraan dapat mengakibatkan penurunan permintaan terhadap layanan tersebut. Sebagai rekomendasi, perusahaan disarankan untuk menyajikan tawaran promosi yang lebih menarik, menyesuaikan harga dengan cakupan regional, dan mempertimbangkan dampak kepemilikan kendaraan yang meningkat dalam penyesuaian model bisnis mereka.
An Analysis of Voice-Controller’s Implementation in Teaching DLP Form-One Mathematics: A Case Study
Authors: Kang Kenny Chin Aik , Abdullah Mohd Faizal Nizam Lee
Published: February 2024

This case study aims to analyze voice-controller (VC)’s implementation of five, national-type secondary schools, Kinta Utara, Ipoh, Perak, teachers in teaching mathematics form-one (T1) Dual Language Programme (DLP). VC consists of three elements: sound level and voice level practice (SL-VL-P); marker and voice level practice (M-VL-P); and activity and voice level practice (A-VL-P). Students’ voice level barrier disturbs teaching and learning. Teacher should control students’ voice level. This study contributes an alternative classroom control strategy for teachers and reflection to Secondary School Standard Curriculum planner about learning and facilitating’s situation in school from communication perspective. Data collection methods were teaching observation, interview, and document analysis. Content analysis method was used to analyze data. The research’s findings indicate the number of participants who had the VC’s goal: cognitive domain (five), affective domain (four), and psychomotor domain (none). Affective domain’s level is limited within receiving and giving response. In VC implementation: (i) The number of participants who implemented SL-VL-P using: routine class explanation (three), reminder (five), oral order (two), repeated conversation (two), blame (one), positive provocation (one), and questioning (two). (ii) The number of participants who implemented M-VL-P using: voice tone (three), body language (three), and teaching aids (none)(iii) The number of participants who implemented A-VL-P using: group size plan (two), activity’s voice level explanation (one), oral order (two), motivation (one), and questioning (two). ‘Giving reminder’ is the common way for all participants. No formal VC drill for students. Two participants faced problem in implementing VC. Conclusion: Five participants’ VC goals are not holistic. Five participants implemented VC undirectedly. There are students unable to perform VC. Implication: Teachers should: (i) plan holistic goals. (ii) plan formal VC. (iii) help students who suffer from voice level barrier. Future study is required to study the relation between voice-level practice and student’s ability to control voice-level.
Engaging Students in Online Data Analytics Learning: Meaningful Learning in Higher Education
Authors: Mohamad Judi Hairulliza , Iksan Zanaton , ‘Sahari @ Ashaari Noraidah
Published: February 2024

The implementation of full online teaching and learning activities in Higher Educational institutions invites tangible challenges to sustain students’ interest and engagement in the course, throughout the semester. Meaningful learning encourages students to develop concepts constructively in active learning that promote the integration of knowledge in daily life and potential career applications. Meaningful learning also applies richer application capabilities in synchronous or asynchronous learning systems. Visualization is a technic to support concept description and imagination and provide an additional effective layer for learning towards increased motivation. In this paper, a discussion of the active involvement of students using visualization in online data analytics courses at the tertiary level is presented. Based on functional context principles of visualized course content, recommendations to practitioners are discussed.
A mechanism for tuning proprioception proposed by research in Drosophila and mammals
Authors: Hunter Iain
Published: February 2024

Proprioception provides important sensory feedback regarding the position of an animal’s body and limbs in space. This interacts with a central pattern generator responsible for rhythmic movement, to adapt locomotion to the demands that an animal’s environment places on it. The mechanisms by which this feedback is enabled are poorly understood, which belies its importance: dysfunctional proprioception is associated with movement disorder and improving it can help reduce the severity of symptoms. Similarly, proprioception is important for guiding accurate robotic movement and for understanding how sensory systems capture and process information to guide action selection. It is therefore important to interpret research that investigates mechanisms of proprioception, to ask: what type of information do proprioceptive sensors capture, and how do they capture it? Work in mammalian models has made important progress towards answering this question. So too, has research conducted Drosophila. Fruit fly proprioceptors are more accessible than mammalian equivalents and can be manipulated using a unique genetic toolkit, so experiments conducted in the invertebrate can make a significant contribution to overall understanding. It can be difficult, however, to relate work conducted in different models, to draw general conclusions about proprioception. This review, therefore, explores what research in the fruit fly has revealed about proprioceptor function, to highlight its potential translation to mammals. Specifically, the present text presents evidence that differential expression of mechanoelectrical transducers contributes to tuning of fly proprioceptors and suggests that the same mechanism may play a role in tuning mammalian proprioceptors.
Forecasting con Python, caso de estudio: visitas a las redes sociales en Ecuador con machine learning
Authors:   Instituto Superior Tecnológico Japón, Marcillo Vera Fabricio Rolando , Rosado Rebeca , Zambrano Pedro , Velastegui Joan , Morales Graciela , Lagla Luis , Herrera Alejandro
Published: February 2024

En este artículo, se enfatiza la importancia del respeto en el uso de las redes sociales en la sociedad ecuatoriana, subrayando su diversidad y la necesidad de fomentar un diálogo constructivo en lugar de la confrontación dañina en línea. Se proporciona una metodología que emplea técnicas de aprendizaje automático y modelado estadístico, como el modelo ARIMA, para predecir el tráfico web en las redes sociales de Ecuador. Además, se discuten diversas estrategias de backtesting para evaluar y mejorar la precisión del modelo a lo largo del tiempo. Los resultados indican un crecimiento significativo en el número de usuarios de redes sociales en Ecuador, con un enfoque en el modelo ARIMA como eficaz para la predicción de series temporales, aunque se sugiere la exploración de enfoques adicionales y mejoras continuas en futuras investigaciones. Este estudio contribuye a comprender mejor el impacto de las redes sociales en la sociedad ecuatoriana y proporciona una base metodológica para pronosticar el tráfico web en estas plataformas en el futuro.
Realidad Aumentada Aplicada en la Supervisión, Mantenimiento de Equipos y Procesos Industriales
Authors:   Instituto Superior Tecnológico Luis Arboleda Martínez, Muñoz Macias Grace , Álvarez Brito Byron , Mero Briones Henry , Muñoz Macias Carolina ,   Universidad Laica Eloy Alfaro de Manabí
Published: February 2024

En la era actual de la industria, la aplicación de la Realidad Aumentada (RA) ha emergido como una herramienta fundamental para mejorar la supervisión y el mantenimiento de equipos y procesos industriales. Este estudio se enfocó en abordar la creciente necesidad de optimizar la eficiencia y la seguridad en entornos industriales complejos. El problema central abordado fue la falta de eficacia en la supervisión y el mantenimiento tradicionales, que a menudo resulta en tiempos de inactividad no planificados y costos significativos. El objeto de estudio fue la implementación de soluciones de RA para mejorar la visualización de datos en tiempo real y proporcionar asistencia guiada a técnicos de campo. El campo investigativo se enmarca en la intersección de la tecnología de RA en la industria, explorando sus aplicaciones prácticas y beneficios potenciales. El objetivo de esta investigación es reducir tiempos de inactividad, mejorando la toma de decisiones y aumentando la eficiencia operativa. La metodología empleada incluye casos de implementación de RA en la industria. Se han examinado tecnologías de RA específicas, como sistemas de seguimiento de activos, visualización de datos en tiempo real y capacitación de técnicos. En conclusión, este estudio demuestra que la aplicación de la Realidad Aumentada en la supervisión y el mantenimiento industrial es altamente efectiva para mejorar la eficiencia y la seguridad, reduciendo costos y aumentando la productividad. La RA se presenta como una solución innovadora y prometedora para abordar los desafíos actuales en la gestión de equipos y procesos industriales.
Prototipo de simulador de parto tipo pelvis con sistema de visualización en tiempo real para el Instituto Universitario American College-2023
Authors:   Instituto Universitario American College, Cuenca Soto María del Cisne , Chuya Zumba Jorge Patricio , Salazar Montesdeoca Sandra Cecilia , Salazar Montesdeoca Diego Mauricio
Published: February 2024

Los simuladores de parto son herramientas educativas utilizadas en entornos médicos y de capacitación para entrenar a futuros profesionales, en el sistema sanitario. El objetivo general de esta investigación es realizar un prototipo de simulador de parto tipo pelvis con un sistema de visualización en tiempo real mediante el módulo ESP-Wroom 32 adaptado a la web para el Instituto Universitario American College. La metodología que se utilizó fue preexperimental de tipo transversal, se desarrolló un prototipo que consta de tres fases que son: diseño, programación y ensamblaje. Para la adquisición y adecuación de los datos se emplea seis sensores que están ubicados en puntos estratégicos en el neonato. Las variables de medición son presión, fuerza y nivel de curvatura, mientras que, para la transmisión de datos hacia la web, se realiza mediante una conexión WIFI que se habilita por medio de una dirección IP con el módulo. El resultado fue, que el simulador de parto se adapta a estos dispositivos con la finalidad de tener un ambiente controlado especialmente durante el proceso enseñanza aprendizaje, los datos que se obtiene permite al estudiante tener una retroalimentación directa en tiempo real, para que en el momento de un parto realice el manejo adecuado.
Pathophysiology of severe gallstone pancreatitis: A new paradigm
Authors: Isogai Masatoshi
Published: February 2024

Severe gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie’s theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic type), in which hepatobiliary and pancreatic lesion severity is inversely related to the presence or absence of impacted ampullary stones. Severe GSP is caused by stones that are persistently impacted at the ampulla with biliopancreatic obstruction (biliary type), and probably, stones that are either temporarily lodged at the duodenal orifice or passed into the duodenum, thereby permitting reflux of bile or possible duodenal contents into the pancreas (pancreas type). When the status of the stones and the presence or absence of impacted ampullary stones with biliopancreatic obstruction are determined, the clinical course and outcome can be predicted. Gallstones represent the main cause of acute pancreatitis globally, and clinicians are expected to encounter GSP more often. Awareness of the etiology and pathogenesis of severe disease is mandatory.
Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children
Authors: Zhang Yu-Hua , Xu Zhi-Hua , Ni Shuang-Shuang , Luo Hong-Xia
Published: February 2024

BACKGROUND

The detection rate of peptic ulcer in children is improving, with development of diagnostic procedures. Gastroscopy is the gold standard for the diagnosis of peptic ulcer, but it is an invasive procedure. Gastrointestinal contrast-enhanced ultrasonography (CEUS) has the advantages of being painless, noninvasive, nonradioactive, easy to use, and safe.

AIM

To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in children.

METHODS

We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June 2022. All children were examined by routine ultrasound, gastrointestinal CEUS, and gastroscopy. The pathological results of gastroscopy were taken as the gold standard. Routine ultrasonography was performed before gastrointestinal CEUS. Conventional ultrasound showed the thickness of the gastroduodenal wall, gastric peristalsis, and the adjacent organs and tissues around the abdominal cavity. Gastrointestinal CEUS recorded the thickness of the gastroduodenal wall; the size, location and shape of the ulcer; gastric peristalsis; and adjacent organs and tissues around the abdominal cavity. The results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal CEUS. All children received informed consent from their guardians for CEUS. This study was reviewed and approved by the hospital medical ethics committee.

RESULTS

Among the 43 children, 17 (15 male, 2 female) were diagnosed with peptic ulcer by gastroscopy. There were 26 children with nonpeptic ulcer. There were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional ultrasound. The diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1% (34/43), which was significantly different from that of gastroscopy (P = 0.033). It indicates that the coincidence rate of gastrointestinal contrast-enhanced ultrasound and gastroscope is low. Fifteen cases of peptic ulcer and 28 of nonpeptic ulcer were diagnosed by CEUS. The diagnostic coincidence rate of peptic ulcer in children was 95.3% (41/43). There was no significant difference between CEUS and gastroscopy (P = 0.655). It indicates that the coincidence rate of gastrointestinal contrast-enhanced ultrasound and gastroscope is high.

CONCLUSION

Gastrointestinal CEUS has a high coincidence rate in the diagnosis of peptic ulcer in children, and can be used as a preliminary examination method.
Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival
Authors: Leung Pui-Yin , Chen Wenjing , Sari Anissa N , Sitaram Poojitha , Wu Pui-Kei , Tsai Susan , Park Jong-In
Published: February 2024

BACKGROUND

Pancreatic cancer is a leading cause of cancer-related deaths. Increased activity of the epidermal growth factor receptor (EGFR) is often observed in pancreatic cancer, and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug administration. Nevertheless, erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic outcomes. We previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential (Δψm), facilitate tumor cell uptake of Δψm-sensitive agents, disrupt mitochondrial homeostasis, and subsequently trigger tumor cell death. Erlotinib has not been tested for this effect.

AIM

To determine whether erlotinib can elevate Δψm and increase tumor cell uptake of Δψm-sensitive agents, subsequently triggering tumor cell death.

METHODS

Δψm-sensitive fluorescent dye was used to determine how erlotinib affects Δψm in pancreatic adenocarcinoma (PDAC) cell lines. The viability of conventional and patient-derived primary PDAC cell lines in 2D- and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone (MitoQ), a Δψm-sensitive MitoQ. The synergy between erlotinib and MitoQ was then analyzed using SynergyFinder 2.0. The preclinical efficacy of the two-drug combination was determined using immune-compromised nude mice bearing PDAC cell line xenografts.

RESULTS

Erlotinib elevated Δψm in PDAC cells, facilitating tumor cell uptake and mitochondrial enrichment of Δψm-sensitive agents. MitoQ triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses, while erlotinib pretreatment potentiated low doses of MitoQ. SynergyFinder suggested that these drugs synergistically induced tumor cell lethality. Consistent with in vitro data, erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each agent.

CONCLUSION

Our findings suggest that a combination of erlotinib and MitoQ has the potential to suppress pancreatic tumor cell viability effectively.
Complementary comments on metastatic liver lesions with exceptional and rare cases
Authors: Memis Kemal Bugra , Aydin Sonay
Published: February 2024

Liver metastases can appear in different forms in magnetic resonance imaging. Contrary to popular belief, while radiologists report hypovascular or hypervascular metastatic lesions, exceptional examples may be detected in various tumors. The aim of this article is to improve this review by presenting rare and atypical examples of liver metastasis, as well as cases that might potentially be misdiagnosed as metastases during the process of differential diagnosis.
Endoscopic ultrasonography-related diagnostic accuracy and clinical significance on small rectal neuroendocrine neoplasms
Authors: Weng Jun , Chen Yu-Fan , Li Shu-Han , Lv Yan-Hua , Chen Ruo-Bing , Xu Guo-Liang , Lin Shi-Yong , Bai Kun-Hao
Published: February 2024

This research aimed to examine the diagnostic accuracy and clinical significance of endoscopic ultrasonography (EUS) in the context of small rectal neuroendocrine neoplasms (NENs). A total of 108 patients with rectal subepithelial lesions (SELs) with a diameter of < 20 mm were included in the analysis. The diagnosis and depth assessment of EUS was compared to the histology findings. The prevalence of NENs in rectal SELs was 78.7% (85/108). The sensitivity of EUS in detecting rectal NENs was 98.9% (84/85), while the specificity was 52.2% (12/23). Overall, the diagnostic accuracy of EUS in identifying rectal NENs was 88.9% (96/108). The overall accuracy rate for EUS in assessing the depth of invasion in rectal NENs was 92.9% (78/84). Therefore, EUS demonstrates reasonable diagnostic accuracy in detecting small rectal NENs, with good sensitivity but inferior specificity. EUS may also assist physicians in assessing the depth of invasion in small rectal NENs before endoscopic excision.
E-Marketing of University Services in Light of Trends in Contemporary Universities
Authors: Mugahed Faez , Al-Abdi Mansour , Al-Makhdi Sharf
Published: February 2024

The study aimed to identify the reality of e-marketing of university services in the light of e-marketing trends in contemporary universities, as perceived by the administrative and academic staff at Amran University in Yemen. The study used a descriptive approach and utilised a questionnaire as a tool of study, which included 32 items distributed over four dimensions of e-marketing of the university services. The study was conducted with a sample of 113 participants from both academic and administrative staff. The findings show a moderate level of e-marketing. There are no statistically significant differences in respondents’ perceptions of e-marketing. he study highlights the necessity to consider e-marketing of the university services and suggests conducting similar research on different samples and programs at the university.
KEYWORDS
Artificial Intelligence, branding, chatbots, electronic conversions, marketing communications, search engines
Yönetim Bilişim Sistemleri & Siber Güvenlik
Authors: Gönüllü Mehmet Alptunga , Tüfekçi Aslıhan , Gelen Dilara , Çatal Haluk , Karaçuha Kemal , Ünlü Nafiz , Solak Ahmet , Solmaz Eser , Demirli Elif
Published: February 2024

Güvenlik Orkestrasyon, Otomasyon ve Olaylara Müdahale (Soar
Mehmet Alptunga Gönüllü, Recep Benzer, Aslıhan Tüfekçi
İlköğretim Müfredatında Siber Güvenlik Konularının İncelenmesi
Dilara Gelenrecep Benzer
Tallınn Manual 2.0 (Tallınn Kılavuzu) ile Siber Savaşta Uygulanacak Uluslararası Hukuk Kurallarına Genel Bakış
Haluk Çatal
Siber Saldırılardan Yeni Nesil Korunma Teknikleri
Kemal Karaçuhanafiz Ünlü
Sızma Testi Ve Uygulama
Ahmet Solakrecep Benzer
Web Uygulamalarına Yapılan Ataklar ve Uygulama
Eser Solmaz
Recep Benzer
Bilişim Terörü ve Bilişim Suçları
Elif Demirlirecep Benzer
Yapay Zekâ Yöntemi ile Reaktif Güç Kompanzasyonu Tekniği
Nafiz Ünlü
Spora Akademik Dokunuşlar
Authors: Dumangöz Pero Duygu , Çifçi Ferhat , Ziyagil M. Akif , Yılmaz Gülsüm , Çumralıgil Burhan , Safi Züleyha , Arıkan İbrahim İhsan , Tutal Varol , Demir Abdurrahman , Barut Ali İlhan , Güney Gamze , Yiğiter Korkmaz , Dolğun Onur Can , Toy Ali Burak , Gündoğan Umut , Göksu Tekmil Sezen
Published: February 2024

Antrenörlük ve Spor EtiğiPero Duygu DUMANGÖZBeden Eğitimi Dersinde Portfolyo Değerlendirme Destekli Öğretimin Öğrencilerin Basketbol Bilgi veBecerilerine EtkisiFerhat ÇİFÇİM. Akif ZİYAGİLBeden Eğitimi ve Spor Dersinde Kullanılan Ders Günlüklerinin Öğrencilerin Bilgi ve Becerisine EtkisiFerhat ÇİFÇİHuzur Evinde Yaşayan Bireylere Yönelik Egzersiz ÇalışmalarıGülsüm YILMAZBurhan ÇUMRALIGİLZüleyha SAFİKas Hırsızı (Sarkopeni) ve Egzersizİbrahim İhsan ARIKANVarol TUTALPandemi Sürecinde Türk Toplumunun Ruh Sağlığı ve Egzersizin EtkisiAbdurrahman DEMİRAli İlhan BARUTSpor TurizmiGamze GÜNEYSpor ve EmpatiKorkmaz YİĞİTERSporda Dijital LiderlikOnur Can DOLĞUNSporda Psikolojik PerformansAli Burak TOYUmut GÜNDOĞANToplam Kalite Bakış Açısıyla SporTekmil Sezen GÖKSU
Tarımsal Sulamada Enerji Yönetimi
Authors: Öztürk Hasan Hüseyin
Published: February 2024

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Efektivitas Ruang pada Revitalisasi Pasar Tradisional dengan Fasilitas Modern di Bali dari Sudut Pandang Perilaku Pengguna
Authors: Prabandari Nyoman Ratih , Sugihantara I Ketut , Wiranata Putu Aldi
Published: February 2024

Kajian ini membahas efektivitas ruang pasar tradisional dengan fasilitas modern (Pasar Modern-Tradisional) berdasarkan perilaku pengguna menggunakan metode post-occupational evaluation (POE). Kajian ini difokuskan pada lokus yang representatif, yaitu Pasar Tradisional Badung sebagai kasusnya. Hasilnya ditemukan dengan mengamati perilaku pengguna dan melakukan analisis konten terhadap beberapa foto situasi terkini di Pasar Modern-Tradisional Badung. Temuan ini didukung dengan mewawancarai 50 pengguna Pasar Modern-Tradisional Badung secara acak, yang diklasifikasikan menjadi 3 kategori – penjual, pembeli reguler (harian), dan pembeli sesekali – untuk mengetahui persepsi dan preferensi pengguna. Membandingkan data untuk menentukan prioritas kebutuhan, sehingga dapat disimpulkan kebutuhan dasar ruang. Ternyata kebijakan pemerintah terhadap pasar tradisional Badung sebagai objek wisata mempengaruhi efektivitas tata ruang di dalamnya. Perancang berusaha mengakomodasi turis/pembeli sesekali namun kurang memperhatikan esensi dari daya tarik pasar tradisional itu sendiri. Studi ini dapat memberikan ide-ide alternatif sebagai dasar untuk merancang pasar tradisional secara efektif.
Percepción de los Usuarios sobre la Implementación del Mingitorio Seco en el C. U. UAEM Valle de Teotihuacan
Authors: Suárez Varela Iztaccíhuatl , Gómez Vidal Anabell
Published: February 2024

Esta investigación tiene como objetivo mostrar la percepción de los sujetos sobre la implementación de los mingitorios secos en el Centro Universitario UAEM Valle de Teotihuacan, para así sensibilizar a la demás población universitaria sobre la implementación de los mingitorios en otros espacios de la misma UAEMex, mostrando que son una alternativa que permite disminuir el uso de agua potable. La implementación de estos mingitorios secos favorece significativamente el uso de los recursos no renovables, así como, la reducción en el impacto ambiental que deriva de los desechos humanos. La metodología empleada es cuantitativa, el tipo de investigación es exploratoria y permite recabar datos que dan explicación a fenómenos. En los resultados se puede observar que, aunque se cuenta con una percepción favorable sobre la implementación de los mingitorios secos es necesario sensibilizar a la población universitaria para que conozcan los beneficios que generan los mismos.
Covid-19 e Hipertensión Arterial y Factores de Riesgo Asociados en la UMF 09, Acapulco Guerrero
Authors: De la Cruz Néstor Benito Armando , Aguilar Hernández Guadalupe
Published: February 2024

Durante la pandemia por  COVID-19 se encontró asociación en los pacientes que padecían hipertensión arterial descontrolada, los cuales tienen mayor riesgo de complicación. Objetivo: Analizar los factores de riesgo asociados a COVID-19 e hipertensión arterial en el año 2022 en la Unidad de Medicina Familiar No. 09 del IMSS, Acapulco, Guerrero. Material y métodos: Estudio transversal analítico, se utilizó muestreo no probabilístico, por conveniencia en pacientes con hipertensión arterial que presentaron prueba rápida positiva a COVID-19 y que acudieron al Módulo de Atención de Enfermedades Respiratorias en la Unidad de Medicina Familiar No. 9 del IMSS, en el año 2022 en Acapulco, Guerrero. Tamaño de la muestra, 290 pacientes. Se trabajó con una base de datos elaborado en base a la revisión de expedientes clínicos electrónicos. Los resultados obtenidos se procesaron por medio del programa estadístico CIETmap SE. Resultados: muestra 290 pacientes, de las cuales mujeres 146 (50.3%). Edad promedio de 50.87, DS de 6.49. Se encontró asociación con tener edad mayor de 40 años para presentar COVID-19 moderado OR 0.4 IC95% 0.16-0.99 p=0.03, el grado de escolaridad también influyó, ORa 4.31, IC95%1.12-16.62 p=0.04. Se encontró relación entre hipertensión arterial descontrolada con COVID-19 moderado OR 1.79 IC95% 1.01-3.18 p=0.04. Conclusiones: pacientes con un nivel de estudios menor de primaria tuvieron un mayor riesgo de contraer COVID-19 moderado.
El Marketing en las Empresas de Salud en Colombia
Authors: Andrade Díaz Karla V , Cabezas Angulo Amanda Giseth , Osuna Jenny Vanessa , Lopez Mallama Oscar Marino , Salazar Villegas Billy
Published: February 2024

El marketing en el sector de la salud utiliza estrategias relacionadas con el producto, precio, distribución y promoción para generar valor en los servicios de salud y establecer relaciones sólidas y duraderas con los clientes. El objetivo es llevar a cabo una revisión sistemática del marketing en salud en Colombia, utilizando la literatura científica de los últimos 7 años (2017-2023). Para lograr esto, se identifica la literatura científica de marketing en salud en Colombia, se caracterizan identificando tipologia de marketing, poblaciones, tipo de estudio y principales tematicas. La metodología sigue un modelo de monografía de tipo documental y alcance descriptivo, que resulta de una investigación bibliográfica con un enfoque sistemático en la literatura científica sobre el marketing en salud en Colombia. La búsqueda específica se realizó en bases de datos como Dialnet, Scopus y BVS, utilizando la ecuación de búsqueda "health marketing" AND "Colombia". Se analizaron un total de 10 artículos de la literatura científica que tratan temas relacionados con marketing, salud, campañas, estudios, servicios, usuarios, comunicación, entre otros. La caracterización revela que los estudios muestran varios tipos de tales como, marketing el social y el estratégico, dirigido a una población heterogénea que incluye usuarios, adolescentes, afiliados al sistema de salud, instituciones prestadoras de servicios y familiares de pacientes. También se abordan temas relacionados con la salud pública.
Pengaruh E-Modul Kemeja Terhadap Hasil Belajar Mahasiswa
Authors: Tania Azahra  , Esty Nurbaity Arrsyi  , Yeni Sesnawati
Published: February 2024

Penelitian ini bertujuan mengetahui pengaruh e-modul kemeja pada pembelajaran mata kuliah Busana Priayang diukur berdasarkan hasil belajar mahasiswa. Penelitian yang dilakukan menggunakan metodepenelitian eksperimen, dengan Pre-Experimental Design tipe Intact-Group Comparison, menggunakanteknik total sampling di mana seluruh mahasiswa S1 Pendidikan Tata Busana yang mengikuti kelas BusanaPria pada semester 118 tahun 2022/2023. Teknik pengumpulan data menggunakan achievement test yangterdiri dari 25 soal pilihan ganda dan 5 soal benar-salah untuk data hasil belajar mahasiswa. Data hasilbelajar dianalisis menggunakan t-test independent. Berdasarkan hasil achievement test dan independent ttestmenunjukkan bahwa terdapat pengaruh penggunaan media pembelajaran e-modul Kemeja denganmateri yang dijelaskan secara step-by-step terhadap hasil belajar mahasiswa kelas Busana Pria
Exploring the Potential of Wireless Integrated Configuration Technology as a Learning Tool
Authors: Nor Masharah Husain  , Nur Dhania Mohamed Safi  , Syamsuriana Sidek
Published: February 2024

The objective of this study was to determine the feasibility of utilising wireless integrated configuration technology among students enrolled in networking courses. The proposed method entails using Raspberry Pi as the key hardware component to facilitate wireless configuration, hence facilitating seamless connectivity and communication across wireless devices. The networking solution facilitates the transport of data, exchange of resources, and cooperation in a wireless manner, eliminating the need for physical cables or wires. The research methodology for this study entails descriptive analysis in the form of a survey, which will have an impact on the quantitative findings. The results of the needs study found that over 90% of students agreed that the use of wireless configuration devices would improve understanding and interest them in doing network configuration. Based on the findings from interview sessions with experts, it has been demonstrated that the utilisation of wireless integrated configuration technology possesses the capacity to engender an enjoyable learning experience for students. This technology enables students to engage in configuration tasks wirelessly, utilising numerous devices concurrently. Additionally, experts believe that students can learn how to configure it technically as well as theoretically. The results of this study were successful in determining the level of potential for the development of wireless devices and their usage in networking courses.
Prototype Development of Final Year Project Management System to Monitor Student’s Performance
Authors: Raznida Isa  , Shuhadah Othman  , Adam Shukry Ali  , Noraliza Azizan  , John Ferguson
Published: February 2024

The university requires students to complete a comprehensive software development project in their final year of study in all Information Technology (IT) and Computer Science (CS) programmes, run by the Faculty of Computing & Multimedia (FCOM), Universiti Poly-Tech Malaysia. As the number of students increases by semester, manual procedures for managing student projects become a major issue. Ineffective supervision and monitoring of student progress are more likely to occur as the number of students to supervise per lecturer also increase. This circumstance may contribute to an increase in the number of students who will fail to complete project development within the time frame specified. A log book is currently used to document meetings and discussions between supervisors and students. Although a detailed schedule has been proposed, a monitoring process that triggers specific actions to ensure all deadlines are met is required. The objective of this research is to improve project monitoring and supervision by developing a prototype of a web-based Final Year Project Management System (FYPMS). The initial prototype is built on the dashboard approach concept, where students can see their progress and lecturers can use this centralized system to monitor students' performance. This system’s users are divided into three groups: students, lecturers, and coordinators where they can communicate efficiently and effectively by using this system. By using the FYPMS, the faculty can look forward to better project management, improved supervision, fewer project delays, and a more efficient final year project process.
An Improved Variational-Based Model for Denoising and Segmentation of Vector-Valued Images
Authors: Nurhuda Ismail  , Abdul Kadir Jumaat  , Nurul Fatin Azara Zulkarnain
Published: February 2024

Preserving important features such as edges is one of the main concerns in models for denoising and segmenting vector-valued (colour) images. The Rudin-Osher-Fatemi (ROF) model is a well-known variational-based image denoising model that is capable of reducing image noise while preserving image edges. However, the ROF model is not formulated for denoising colour images and is less effective in preserving corners and weak edges. On the other hand, a variational-based selective segmentation model for colour images called the selective distance segmentation (DSS2) model has recently been proposed, which can effectively partition or extract a specific object in an image. However, the DSS2 model has problems in segmenting colour images with noise, which may result in poor segmentation. Therefore, in this research, we first modify the ROF model to denoise vector-valued images by including the edge detector and extending the formulation into a vector-valued framework. Second, we reformulate the DSS2 model by incorporating the modified ROF model as a new fitting term in the DSS2 model. Peak signal-to-noise ratio (PSNR) is used to measure the image quality, while Jaccard and Dice similarity index are used to evaluate the segmentation quality. The comparison between our proposed model and existing model shows that our model is more effective as indicated by higher PSNR, Jaccard and Dice similarity index values.