bluuebunny/crossref_metadata_2025 huggingface dataset:
Changing the daily injection of glatiramer acetate to a monthly long acting product through designing polyester-based polymeric microspheres
Authors: Molavi Fatima , Barzegar-Jalali Mohammad , Hamishehkar Hamed
Published: November 2022

Introduction: Glatiramer acetate (GA) is a newly emerged therapeutic peptide to reduce the frequency of relapses in multiple sclerosis (MS). Despite its good performance in controlling MS, it is not widely used due to daily or biweekly subcutaneous injections due to rapid degradation and body clearance. Therefore, implant design with sustained release leads to prolonged biological effects by gradually increasing drug exposure and protecting GA from rapid local degradation. Methods: Different emulsion methods, PLGA type, surfactant concentration, drug/polymer ratio, drying processes, stirring method, and other variables in preliminary studies modified the final formulation. The release kinetics were studied through mechanistic kinetic models such as zero-order, Weibull, Higuchi, etc. In this study, all challenges for easy scale-up, methodological detail, and a simple, feasible setup in mass production were discussed. Results: The optimized formulation was obtained by 1:6 drug/PLGA, 0.5% w/w polyvinyl alcohol, and 0.75% w/w NaCl in the external aqueous phase, 1:10 continuous phase to dispersed phase ratio, and without any surfactant in the primary emulsion. The final freeze-dried particles presented a narrow distributed size of 1-10 µm with 7.29% ± 0.51 drug loading and zero-order release behavior with appropriate regression correlation (R2 98.7), complete release, and only 7.1% initial burst release. Conclusion: Therefore, to achieve improvement in patient compliance through better and longer efficacy, designing the parenteral sustained release microspheres (MPSs) of this immune modulator is a promising approach that should be considered.
Synthesis, characterization, and evaluation of pH-sensitive doxorubicin-loaded functionalized graphene oxide in osteosarcoma cells
Authors: Alemi Forough , Maleki Masomeh , Mir Mostafa , Ebrahimi-Kalan Abbas , Zarei Mojtaba , Yousefi Bahman , Rashtchizadeh Nadereh
Published: November 2022

Introduction: Doxorubicin (DOX) is one of the most common drugs in cancer treatment. However, its partial solubility along with the high incidence of side effects remains a challenge to tackle. To address these issues, we designed a formulation based on graphene oxide (GO) and used it as an anticancer drug delivery system. Methods: The physical and chemical properties of the formulation were studied using FTIR, SEM, EDX, Mapping, and XRD. Release studies in the in vitro condition were used to evaluate the pH sensitivity of drug release from nanocarriers. Other in vitro studies, including uptake assay, MTT, and apoptosis assay were carried out on the osteosarcoma (cell line. Results: In vitro release studies confirmed that the synthesized formulation provides a better payload release profile in acidic conditions, which is usually the case in the tumor site. On the OS cell line, the cytotoxicity of the DOX-loaded nanocarrier (IC50=0.293 μg/mL) and early apoptosis rate (33.80 % ) were higher in comparison to free DOX (IC50=0.472 μg/mL, and early apoptosis rate= 8.31 % ) after 48 hours. Conclusion: In summary, our results suggest a DOX-loaded graphene oxide carrier as a potential platform for targeting cancer cells.
Injectable thermosensitive chitosan/gelatin hydrogel for dental pulp stem cells proliferation and differentiation
Authors: Samiei Mohammad , Dalir Abdollahinia Elaheh , Amiryaghoubi Nazanin , Fathi Marziyeh , Barar Jaleh , Omidi Yadollah
Published: November 2022

Introduction: Biocompatible and biodegradable scaffolds based on natural polymers such as gelatin and chitosan (CS) provide suitable microenvironments in dental tissue engineering. In the present study, we report on the synthesis of injectable thermosensitive hydrogel (PNIPAAm-g-CS copolymer/gelatin hybrid hydrogel) for osteogenic differentiation of human dental pulp stem cells (hDPSCs). Methods: The CS-g-PNIPAAm was synthesized using the reaction of carboxyl terminated PNIPAAm with CS, which was then mixed with various amounts of gelatin solution in the presence of genipin as a chemical crosslinker to gain a homogenous solution. The chemical composition and microstructures of the fabricated hydrogels were confirmed by FT-IR and SEM analysis, respectively. To evaluate the mechanical properties (e.g., storage and loss modulus of the gels), the rheological analysis was considered. Calcium deposition and ALP activity of DPSCs were carried out using alizarin red staining and ALP test. While the live/dead assay was performed to study its toxicity, the real-time PCR was conducted to investigate the osteogenic differentiation of hDPSCs cultured on prepared hydrogels. Results: The hydrogels with higher gelatin incorporation showed a slightly looser network compared to the other ones. The hydrogel with less gelatin indicates a rather higher value of G', indicating a higher elasticity due to more crosslinking reaction of amine groups of CS via a covalent bond with genipin. All the hydrogels contained viable cells with negligible dead cells, indicating the high biocompatibility of the prepared hydrogels for hDPSCs. The quantitative results of alizarin red staining displayed a significant rise in calcium deposition in hDPSCs cultured on prepared hydrogels after 21 days. Further, hDPSCs cultured on hydrogel with more gelatin displayed the most ALP activity. The expression of late osteogenic genes such as OCN and BMP-2 were respectively 6 and 4 times higher on the hydrogel with more gelatin than the control group after 21 days. Conclusion: The prepared PNIPAAm-g-CS copolymer/gelatin hybrid hydrogel presented great features (e.g., porous structure, suitable rheological behavior, and improved cell viability), and resulted in osteogenic differentiation necessary for dental tissue engineering.
Vandetanib alters the tumoricidal capacity of human breast cancer stem cells via inhibiting vasculogenic capacity
Authors: Haiaty Sanya , Rashidi Mohammad-Reza , Akbarzadeh Maryam , Bazmany Ahad , Mostafazadeh Mostafa , Nikanfar Saba , Shabkhizan Roya , Rezaeian Rostam , Rahbarghazi Reza , Nouri Mohammad
Published: November 2022

Introduction: The inhibition of vascularization into tumor stroma as well as dynamic cell growth is the center of attention. Here, we aimed to examine the role of vandetanib on angiogenesis capacity of breast cancer stem cell (CSCs). Methods: MDA-MB-231 cells were exposed to different doses of vandetanib and survival rate was monitored. Stimulatory effects of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF) were evaluated in vandetanib-treated MDA-MB-231 cells. In vitro tubulogenesis capacity was studied on the Matrigel surface. The synergistic effects of vandetanib on cell survival were also assessed after PI3K and/or Wnt3a inhibition. Vascular endothelial (VE)-cadherin, matrix metalloproteinase-2 (MMP-2), -9, Wnt3a, and p-Akt/Akt ratio were measured using western blotting. Results: Vandetanib reduced survival rate in a dose-dependent manner (P < 0.05). Proliferative effects associated with VEGF, FGF, and EGF were blunted in these cells pre-exposed to vandetanib (P < 0.05). The microcirculation pattern’s triple-negative breast cancer (TNBC) was suppressed by 1, 5 µM of vandetanib (P < 0.05). Hence 1, 5 µM of vandetanib potentially decreased the population of CD24– cells. 1 and 5 µM of vandetanib inhibited cell proliferation by blocking PI3K and Wnt3a pathways and decreased the p-Akt/Akt ratio, Wnta3 protein levels (P < 0.05). 1 and 5 µM vandetanib combined with PI3K inhibitor diminished metastatic markers including, MMP-2, and MMP-9. The concurrent treatment (PI3K, inhibitor+ 1, 5 µM vandetanib) also considerably reduced epithelial-mesenchymal transition (EMT) markers such as VE-cadherin (P < 0.05). Conclusion: Vandetanib suppressed vasculogenic mimicry (VM) networking through blunting stemness properties, coincided with suppression of VE-cadherin in CSCs.
Comparison of Prescribing Pattern of Prophylactic Antibiotics with the Standard Instructions in the General Surgery Department of Hospitals
Authors: Jafary Hasan , Zarezadeh Mohammad , Mojallal Najar Fatemeh , Darrehshiri Somaiye
Published: November 2022

Background. Prescribing prophylactic antibiotics before surgery is one way to prevent infection at the surgical site. The aim of this study was to compare the pattern of prescribing prophylactic antibiotics with the standard instruction in the general surgery ward of Shahid Sadoughi Hospital in Yazd. Methods. A descriptive cross-sectional design was employed to conduct the study. The sample was selected through random stratified sampling method using Morgan and Krejcie sampling table. Descriptive statistical tests including frequency, frequency percentage, mean, standard deviation and Chi-square were used for the analysis of data by SPSS software version-23. Results. Out of 236 cases reviewed, 27.1% met the practice guidelines regarding the time, 39.4% regarding the type of preoperative prophylaxis and 58% with respect to the duration of the prescribed postoperative antibiotics (Up to 24 hours after surgery). Conclusion. The most important reasons for the inconsistency of prophylactic antibiotics with the standard guideline are the inappropriate timing of prophylactic antibiotics and the use of antibiotics that are not recommended in the clinical guidelines. Informing and educating the public on the content of the notification instructions, establishing a monitoring system and increasing the participation level of the hospital pharmacy in the distribution of medicine can be effective in prescribing prophylactic antibiotics.
Designing a Pattern of Relationship between the Functions of the Intermediary Institutions of Open Innovation in Health System
Authors: Salmani Mohammad , Feghhi Farahmand Nasser , Alavi Matin Yaghoob , Khodaie Mahmoudi Reza
Published: November 2022

Background. The health system generally comprises a variety of players. In the health system, there are intermediary institutions of innovation, playing a key role in reducing the distance between the members of the network and building trust among them. Therefore, this study aimed at developing pattern of relationship between the function of the intermediary institutions of open innovation in the health system. Methods. This study was conducted in two main phases. The first phase was carried out to identify and approve the principal components of the function of the intermediary institutions in the health. The data were collected based on the researcher-made questionnaire in accordance with the existing research literature. It was distributed among 140 managers and experts of the research and quality improvement divisions of the clinical centers, laboratories, and pharmaceutical companies. The data were analyzed, using confirmatory factor analysis. In the second phase, interpretive structural modeling (ISM) was employed to design the pattern of relationship. Experts’ view of 12 members were used for designing the pattern. Interpretive structural modeling was used for developing various parts of the questionnaire. Results. The findings of the confirmatory factor analysis are an indication of the proper relationship between the principal components and the respective indicators. Accordingly, all principal components of the pattern of the functions of the intermediary institutions were confirmed in the statistical population of the research. Based on the interpretive structural modeling, the findings revealed that two components, i.e. organizing and supplying resources and strengthening the network and participation, were the two main and most effective functions of the intermediary institutions. The component of commercialization was the most susceptible function of the intermediary institutions and ranked first in this regard. Conclusion. The intermediary institutions can reduce the deficits in each stage of the process of innovation in the field of health according to their various functions, serving as an accelerator increasing the knowledge and innovation in the field of health.
Elderly's Viewpoints on Components of Age-Friendly Cities: A Cross Sectional Study
Authors: Barzanjeh Atri Shirin , Asrari Basmenj Hasan , Sheikhnezhad Leila , Asghari Jafarabadi Mohammad , Hosseinzadeh Mina , Jabbarzadeh Tabrizi Faranak
Published: November 2022

Background. The concept of age-friendly cities has been introduced by the World Health Organization in order to pay more attention to the elderly. In Iran, this issue is more important due to demographic changes and age conditions. Therefore, this study was conducted to investigate the views of the elderly in Tabriz city of Iran about some indicators of age-friendly cities. Methods. In this cross-sectional descriptive-analytical study, 351 elderly people from the 6 centers in Tabriz were selected as the participants of the study through simple random method. The data collection tool was the standard questionnaire of the World Health Organization (WHO) in an age- friendly city. To analyze the data, both descriptive statistics (frequency, frequency percentage, mean and standard deviation) and analytical statistics (analysis of variance and t-test) were used using SPSS software ver.16. at a significance level of 0.05. Results. Among the four indicators studied, the health component had the highest average 44.57 (11.81) and then the components of social respect with a mean score of 38.5 (11.5), participation in social relations 34.8 (9.12) and the cultural and recreational index 32.86 (10.54) (range 1-100) were found to gain high means, respectively. A significant relationship between gender and marriage with cultural-recreational component (P = 0.002) was also observed. Conclusion. Regarding the fact that none of the four indicators of age-friendly cities in Tabriz were standard, so the managers of organizations incharge of aging need to make an attempt to achieve the desired conditions
Human Caring: A Concept Analysis
Authors: Ghanbari-Afra Leila , Adib-Hajbaghery Mohsen , Dianati Mansour
Published: November 2022

Introduction: Human caring combines science, art, and humanity. Humanity is the heart of care and interpersonal interactions. Despite the critical emphasis on human caring and concern for nursing care without humanity, there is no clear definition for human caring in nursing. This study aimed to analyze the concept of human caring. Methods: Walker and Avant’s strategy for concept analysis was used. Electronic databases such as PubMed, Scopus, Ovid, Google Scholar, Magiran, Iran Doc, SID, and a number of dictionaries were searched without any limitation in date. Search keywords were "care", "caring", "human caring", "humanization", "patient care", "comprehensive care" and "nursing care". We searched all documents published before September 2020. In the initial search, 1637 articles were found but finally, 39 relevant articles remained in the study. Results: The nine defining attributes of human caring were establishing therapeutic communication, presence at the patient bedside, empathy, providing scientific care, subjectivity, dynamicity, respecting the patient’s rights and ethics of care, helping the patient achieve a feeling of well-being, and art and creativity. Antecedents of human caring were categorized into three categories namely, human, personal, and organizational factors. The consequences were also categorized into consequences related to nurse, profession, patient, and organization. Conclusion: A theoretical definition and a conceptual model of human caring were developed. This concept should be included in the nursing curricula at all undergraduate and graduate levels and even in nurses’ in-service training programs.
Total endovascular repair of a malpositioneted frozen elephant trunk with Thoraflex hybrid prosthesis: A case report
Authors: Buia Francesco , Di Marco Luca , Pacini Davide , Lovato Luigi
Published: November 2022

We report a case of a 56-year-old male who underwent Frozen Elephant Trunk procedure for residual type A chronic aortic dissection, complicated by the release of the distal endovascular portion of the hybrid prosthesis in the false lumen. This complication was successfully treated with a totally endovascular approach.
Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women
Authors: Heidari Behnam , Zolfaghari Mohammad Reza , Khademvatani Kamal , Fattahi Amir , Zarezadeh Reza
Published: November 2022

Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and bradykinin (BK) and their association with cardiac hypertrophy. Methods: 22 non-athlete and 22 athlete women were exposed to acute (Bruce test) and chronic (12-week swimming training) exercises. 2D echocardiography was used to evaluate morphological and functional features of the heart. Plasma concentrations of TK and BK were quantified by ELISA. Results: Athletes had significantly higher values of left ventricle end-diastolic diameter index (LVEDDI) and left ventricle mass index (LVMI) than non-athletes. Exercise intervention affected echocardiographic features in neither of the study groups. Chronic exercise training notably increased plasma levels of TK and BK, which increase was more pronounced in the athletes. Plasma TK negatively correlated with LVEDDI (r=−0.64, P=0.036 and r=−0.58, P=0.027) and LVMI (r=−0.51, P=0.032 and r=−0.63, P=0.028) in the non-athlete and athlete groups. In opposition, there was a positive correlation between plasma TK and left ventricle ejection fraction in non-athletes (r=0.39, P=0.049) and athletes (r=0.53, P=0.019). Conclusion: The upregulation of the tissue kallikrein-kinin system may be a protective mechanism against excessive cardiac hypertrophy induced by chronic exercise training.
Value of myocardial deformation parameters for detecting significant coronary artery disease
Authors: Rumbinaite Egle , Karuzas Arnas , Verikas Dovydas , Jonauskiene Ieva , Gustiene Olivija , Mamedov Arslan , Jankauskiene Loreta , Benetis Rimantas , Zaliunas Remigijus , Vaskelyte Jolanta Justina
Published: November 2022

Introduction: The study aimed to evaluate the diagnostic value of global and regional myocardial deformation parameters derived from two-dimensional speckle-tracking echocardiography to detect functionally significant coronary artery stenosis. Methods: Dobutamine stress echocardiography and cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI) were performed on 145 patients with a moderate and high probability of coronary artery disease (CAD) and LVEF≥55%. Significant CAD was defined as>50% stenosis of the left main stem,>70% stenosis in a major coronary vessel, or in the presence of intermediate stenosis (50-69%) validated as hemodynamically significant by CMRMPI. Patients were divided in two groups: non-pathological (48.3%) vs pathological (51.7%), according to CAG and CMR-MPI results. Afterwards, off-line speckle-tracking analysis was performed to analyse myocardial deformation parameters. Results: There were no differences in myocardial deformation parameters at rest between groups, except global longitudinal strain (GLS) and global radial strain (GRS) were significantly lower in the CAD (+) group: -21.3±2.2 vs.-16.3±2.3 (P<0.001) and 39.7±23.2 vs. 24.5±15.8 (P<0.001). GLS and regional longitudinal strain rate (SR) had the highest diagnostic value at high dobutamine dose with AUC of 0.902 and 0.878, respectively. At early recovery, GLS was also found to be the best myocardial deformation parameter with a sensitivity of 78%, specificity 67%, AUC 0.824. Conclusion: Global and regional myocardial deformation parameters are highly sensitive and specific in detecting functionally significant CAD. The combination of deformation parameters and WMA provides an incremental diagnostic value for patients with a moderate and high probability of CAD, especially the combination with regional longitudinal SR.
Educational Intervention in Promoting Fatty Liver Preventive Behaviors in Women: Using the Protection Motivation Theory
Authors: Sharifi Nader , Hashemian Masoumeh , Rahimi Zahra , Joveini Hamid , Mehri Ali , Shahrabadi Reza , Rahmanian Vahid
Published: November 2022

Background: The aim of this study was to determine the effect of educational intervention on improving the preventive behaviors of fatty liver in women referring to comprehensive health service centers in Bardaskan using the protection motivation theory (PMT). Materials and Methods: This quasi-experimental study was conducted on women aged 18-59 in Bardaskan in 2020. The sample size was determined as 128 according to the suggestion (Cohen), including 64 experimental and 64 control samples. The participants completed a researcher-made questionnaire consisting of three parts (demographic variables, constructs of PMT, and fatty liver prevention behaviors). The educational intervention for the experimental group was performed in 12 one-hour sessions over 4 weeks using lectures, group discussions, questions and answers, brainstorming, substitution experiences, and delivery of the designed educational booklet. Two months after the completion of the educational intervention, the questionnaire was completed again by all participants. The obtained data were analyzed by SPSS 21 using descriptive statistics, Chi-square test, independent t test, paired t test, ANCOVA test, and linear regression test. Results: There was a significant difference between the mean scores of perceived susceptibility (P<0.001), perceived severity (P=0.002), perceived external and internal rewards (P=0.010), response efficiency (P=0.010), perceived cost (P<0.001), and behavior (P=0.028) between the experimental and control groups after the educational intervention. Conclusion: Educational intervention based on PMT led to behavior modifications to promote the preventive behaviors of the fatty liver.
Effect of ethyl acetate fraction of Costus afer on glycaemic control and essential haematological and biochemical indices of streptozotocin-induced diabetic rats
Authors: Ezeigwe Obiajulu Christian , Onwusulu Daniel Nnaemeka , Adindu Chukwuemeka Steve , Okani Chukwudi Onyeaghana , Onuegbu Maryclare Ebubechukwu
Published: November 2022

Introduction: Diabetes mellitus is a common global cause of sudden unpredictable death if undiagnosed and untreated. Costus afer (Costaceae) is a tropical plant with quite a lot of pharmacological properties. This study investigated the prophylactic and antidiabetic properties of ethyl acetate fraction of C. afer in streptozotocin-induced diabetic rats. Methods: Acute toxicity (LD50) test was done using Lorke’s method. Haematological indices were determined using haematology autoanalyser. The biochemical assays were done using standard diagnostic methods. Results: The lethal dose was 3807.9 mg/kg. There was a significant reduction (P < 0.05) in the fasting blood glucose concentration from week one to week four in the group that was pre-treated and later post-treated with 200 mg/kg body weight (bw) of the ethyl acetate fraction of C. afer leaves compared with the untreated diabetic control. The result of the hematological parameters revealed a significant increase (P < 0.05) in the hemoglobin, packed cell volume (PCV), and platelet count of the group pretreated and treated with 200 mg/kg of the fraction compared with the untreated diabetic control. The result of the biochemical assays revealed a far much better recovery from the disruptions caused by the induction of experimental diabetes as seen in the groups that were initially pretreated with 100 and 200 mg/kg before the induction of diabetes compared with the groups treated with the same dose but without pretreatment. Conclusion: C. afer might be used for the prevention and management of diabetes mellitus. Its safety is evidenced by its effects on the hematological and biochemical indices.
Evaluation of mortality of COVID-19 patients with acute kidney injury (AKI) in comparison to the non-AKI patients
Authors: Shahbazian Heshmatollah , Tafazoli Mina , Sabet Nia Leila , Ghorbani Ali , Ahmadi Halili Shahla , Jahangiri Mehr Fatemeh
Published: November 2022

Introduction: Acute kidney injury (AKI) is prevalent in the coronavirus disease-2019 (COVID-19). There are little data on the relationship between renal dysfunction and COVID-19 prognosis. Objectives: The aim of this research was to investigate the effects of AKI in COVID-19 patients hospitalized to the Golestan and Razi hospitals in Ahvaz, Iran. Patients and Methods: In this retrospective cohort study, a total of 194 COVID-19 patients were included, consisting of 79 patients with AKI and 115 patients without AKI. Primary and secondary outcomes were compared between the two groups. Results: According to the findings, mortality was significantly different between the two groups, and mortality was higher in the AKI group (P< 0.001). The mean length of hospital stay was statistically significantly higher in the AKI group (P=0.024). Moreover, there was a significant correlation between intensive care unit (ICU) admission and the study group (P<0.001). Staging of AKI group were seen as; stage I (49.37%), stage II (36.71%), and stage III (13.92%). No significant correlation was observed between outcome and the stages of AKI (P=0.496). Furthermore, 14 patients (17.72%) needed renal replacement therapy (RRT) in the AKI group. Conclusion: Although AKI is a common finding in COVID-19 patients, most patients were in stage I disease, which returned to normal after COVID-19 treatment. According to our research, COVID-19 rarely leads to serious and persistent kidney injury. However, the risk of death is increased in COVID-19 patients with AKI. Therefore, it is necessary to evaluate the renal function tests during the course of disease.
Determinants of left ventricular diastolic dysfunction in hemodialysis patients
Authors: Dragos Dorin , Timofte Delia , Ionescu Dorin , Balcangiu-Stroescu Andra-Elena , Ghenu Maria Iuliana , Vacaroiu Ileana Adela , Manea Maria Mirabela
Published: November 2022

Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence morbidity and mortality, most severe in patients with end stage renal disease. Objectives: The working hypothesis was that in patients on chronic hemodialysis the prevalence of left ventricular diastolic dysfunction is correlated with the inflammatory, oxidative, metabolic, nutritional, and atherosclerotic status. Patients and Methods: An observational study was performed on 51 patients (age 59.76 ± 13.24 years) on hemodialysis treatment. Transthoracic cardiac ultrasound was conducted to evaluate LVDD. The burden of cardiac and arterial atherosclerosis was evaluated by cardiac ultrasound (aortic and mitral valve calcifications), vascular ultrasound (carotid and femoral atheroma plaques, common carotid intima-media thickness), and by abdominal radiography (aortic calcification score). Demographic and anthropometric parameters were determined. Blood samples were used to determine laboratory parameters reflecting the inflammatory, oxidative, and metabolic/nutrition status. Results: LVDD is positively correlated with the serum level of C-reactive protein (CRP) (P=0.04), the total antioxidant capacity of the serum (P=0.04), the presence (P=0.022) and number (P=0.04) of femoral plaques, the aortic calcification score (P=0.02), aortic valve stenosis (P=0.037), aortic annulus calcifications (P=0.02) and mitral valve calcifications (P=0.041). After the removal of the main confounder, degenerative aortic stenosis, only the associations with serum total antioxidant capacity (P=0.04) and aortic calcification score (P= 0.02) maintain their statistical significance. Conclusion: LVDD is positively correlated with inflammation and oxidative stress markers and with the severity of aortic calcification.
Analysis of Klebsiella Pneumoniae Isolates with Extremely High Antibiotic Resistance
Authors: Егоров С.К. , Семёнов В.М. , Дмитраченко Т.И.
Published: November 2022

Введение. Klebsiella pneumoniae – хорошо известный, традиционно считающийся условно-патогенным микроорганизм. K. pneumoniae способна служить причиной целого ряда тяжелых инфекций у пациентов с ослабленным иммунитетом, страдающих сахарным диабетом, злокачественными новообразованиями, алкогольной зависимостью, а также у лиц, подвергающихся медицинскому вмешательству, как правило, развивающихся в условиях стационара.Цель. Определение генетических характеристик и детерминант антибиотикорезистентности (генов, мутаций, однонуклеотидных полиморфизмов), обуславливающих широкую резистентность к антибиотикам изолятов K. Pneumoniae, выделенных от пациентов реанимационных отделений.Материалы и методы. Выполнено полногеномное секвенирование найденных изолятов с широкой резистентностью к антибиотикам. Проведен генетический анализ нуклеотидных последовательностей.Результаты. Определены сиквенс-типы, капсульные типы, локусы поверхностных полисахаридов исследуемых изолятов Klebsiella pneumoniae. Найдены гены и плазмиды, способные детерминировать резистентность к антибиотикам.Выводы. Результаты указывают на циркуляцию гипервирулентных штаммов Klebsiella pneumoniae в Республике Беларусь, что затрудняет клиническую диагностику и может сопровождаться неэффективностью проведения стандартной антибактериальной терапии у пациентов различного возраста, что имеет особое значение для отделений интенсивной терапии и отделений патологии новорожденных.

Introduction. Klebsiella pneumoniae is a well-known pathogen which is considered opportunistic. It can cause a severe infection in immunocompromised patients with diabetes mellitus, malignant neoplasms, alcohol dependence, as well as in individuals undergoing medical intervention, usually in hospital conditions.Purpose. To establish genetic characteristics and determinants of drug- resistance to antibiotics (genes, mutations, single-nucleotide polymorphisms) responsible for extensive antibiotic resistance of K. Pneumoniae isolates from intensive care unit patients.Materials and methods. Full-genome sequencing and genetic analysis of the primary nucleotide sequences was performed.Results. Sequence types, capsule types, and surface polysaccharide loci of Klebsiella pneumoniae isolates were determined. Genes and plasmids capable of determining resistance to antibiotics were found and characterized.Conclusions. The results indicate the presence of hypervirulent strains of Klebsiella pneumoniae, which complicates diagnosing and may be accompanied by the ineffectiveness of standard antibiotic therapy in patients of different ages, being of particular importance for intensive care units and neonatal pathology departments.
Comparison of Mechanical and Physical Properties of Screed with and without Expanded Polystyrene (EPS) Particles
Authors: Kılıç Fikret Merih , Yorulmaz Hediye , Özuzun Sümeyye , Durak Uğur , İlkentapar Serhan , Karahan Okan , Atiş Cengiz
Published: November 2022

In this study, in order to observe the mechanical and physical properties of ordinary screed, sandy-lightweight screed and lightweight screed samples, expanded polystyrene (EPS) was used as fine aggregate and lightweight screed systems were produced by replacing sand at 100%, 50% and 0%. Samples of cement dosages of 250, 300, 350 kg/m3 were produced for lightweight screeds, sandy-lightweight screeds and ordinary screeds. Unit weight, water absorption capacity, flexural strength, compressive strength, fire resistance, abrasion and thermal conductivity tests were performed on the produced screed systems. As a result of the research, it was determined that as EPS ratio increases in screed system; unit weights decreased, water absorption rates increased. Besides, the flexural and compressive strengths, fire and abrasion resistance are also decreased. However, it was observed that the thermal conductivity coefficient reduced with the increment of EPS particles in the screed. In normal, sandy-lightweight and lightweight screeds, it was determined that as the cement dosage increased; the unit weights, flexural and compressive strengths, fire and abrasion resistance increased, water absorption capacity and the thermal conductivity coefficient decreased.
Analisa OEE dan FMEA Untuk Menigkatkan Perfoma Mesin Sliter di PT PAS
Authors: Widyantoro Murwan , Martono Martono , Paduloh Paduloh
Published: November 2022

PT. PAS is a company that produces noodles with the brand mie sedap. Based on the production data from the previous year, the noodle product activities carried out by PT. PAS, each month has not reached the target due to the time the damage occurred to the noodle slitter machine. So it is necessary to research to determine the performance of the noodle slitter machine using the OEE and FMEA methods. Based on the calculation results of the OEE value of the slitter machine is 76%, it can be concluded that the performance of the slitter machine is not ideal. Based on the analysis using FMEA, the cause of losses due to defect & rework losses is slitter syncing, and losses due to idling and minor stoppages are slitter shooting. The result of the implementation is that there is a significant increase in the OEE value after repairs to the slitter machine with an average OEE value of 91% so that the results of the improvements made by making automatic lubrication modifications can improve the performance of the slitter machine to ideal performance.Keywords— FMEA, OEE, Losses, Slitter
RANCANG BANGUN ALAT FIXED STEERING ROLLER UNTUK MENCEGAH MISTRACKING PADA BELT CONVENER
Authors: Budiharja Yuniar Anis , Darmanto Seno , Mangestiyono Wiji
Published: November 2022

Fix the Steering Roller, Where the purpose of making this tool is to prevent mistracking on the Belt Conveyor. The manufacture of this tool was carried out considering the need for PLTU Nagan Raya 2 x 110 MW. PLTU itself is a coal-fired power plant where all coal needs from the Jetty to the Bunker are transported using a Belt Conveyor. In fact, when transporting coal using a Belt Conveyor, there are a lot of coal spills on the Belt side so that it really interferes with the work process of the conveyor belt itself. The spill was caused by a tilted conveyor belt or it could be called mistracking. Therefore, the manufacture of this tool is a solution to prevent mistracking where the installation of this tool is very easy and does not interfere with the existence of the Belt Conveyor equipment itself.
PENGARUH KOMPETENSI AUDITOR TERHADAP KUALITAS AUDIT DENGAN INTEGRITAS SEBAGAI VARIABEL MODERASI PADA KANTOR AKUNTAN PUBLIK KOTA MEDAN
Authors: Tina Agus
Published: November 2022

Penelitian ini bertujuan untuk mengetahui, menguji dan menganalisis secara empiris tentang pengaruh kompetensi terhadap kualitas audit yang dimoderatori oleh integritas pada Kantor Akuntan Publik di Medan. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan asosiatif. Objek penelitian ini adalah para auditor yang bekerja pada Kantor Akuntan Publik di Medan. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah stratified random sampling dengan jumlah sampel 63 responden dari total populasi 168 responden. Teknik pengumpulan data dilakukan dengan menyebarkan kuesioner. Sedangkan teknik analisis data menggunakan model persamaan struktural partial least square (SEM-PLS) yang diolah menggunakan software statistik Smart PLS. Hasil penelitian menunjukkan bahwa Kompetensi tidak berpengaruh terhadap kualitas audit pada Kantor Akuntan Publik di Medan. Namun integritas dapat memoderasi pengaruh kompetensi terhadap kualitas audit pada Kantor Akuntan Publik di Medan.
PENGARUH PERPUTARAN KAS, PERPUTARAN PIUTANG DAN PERPUTARAN PERSEDIAAN DALAM MENINGKATKAN LABA (Studi Kasus Pada Perusahaan Farmasi Yang Terdaftar Di Bursa Efek Indonesia tahun 2016-2020)
Authors: Savitri Nurliza Erdiyani , Rifkhan Rifkhan
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh perputaran kas, piutang, dan perputaran persediaan terhadap peningkatan laba pada perusahaan farmasi yang terdaftar di Bursa Efek Indonesia. Populasi berupa laporan keuangan 9 perusahaan farmasi yang terdaftar di Bursa Efek Indonesia periode 2016-2020 yang terdiri dari laporan posisi keuangan (neraca) dan laba rugi sebagai sumber data untuk melakukan penelitian. Metode analisis data yang digunakan adalah analisis regresi data panel. Jenis data yang digunakan adalah data sekunder dan penelitian ini menggunakan pendekatan kuantitatif, dengan jenis penelitian asosiatif. Hasil penelitian dengan uji T ini menunjukkan bahwa secara parsial perputaran kas, piutang, dan perputaran persediaan berpengaruh signifikan terhadap laba sedangkan hasil uji F menunjukkan perputaran kas.
PENINGKATAN SKILL PENYUSUNAN LAPORAN ARUS KAS BAGI SISWA SEKOLAH MENENGAH KEJURUAN
Authors: Challen Auliffi Ermian , Fitri Hadiati , Hasan Nida Nadya
Published: November 2022

Tujuan penyusunan laporan arus kas adalah untuk mengetahui realisasi penerimaan dan pengeluaran kas perusahaan sehingga dapat diketahui potensi realisasi kas di masa yang akan datang. Metode penyusunan laporan arus kas  ada 2 yakni metode langsung dan tidak langsung. Namun karena kurangnya pemahaman mengenai tahapan penyusunan laporan arus kas sehingga masih terdapat siswa siswi SMK yang belum bisa membuat laporan arus kas. Tujuan pelaksanaan pelatihan ini adalah peningkatan kompetensi siswa dalam penyusunan laporan arus kas menggunakan metode langsung dan metode tidak langsung menggunakan microsoft excel. Target pelaksanaan pelatihan ini adalah siswa siswi di SMK Negeri 14 Jakarta. Kegiatan dilaksanakan dalam bentuk ceramah, diskusi, praktik, dan pendampingan. Hasilnya 70% peserta telah mampu menyusun laporan arus kas metode langsung dan tidak langsung menggunakan aplikasi microsoft excel
KEBERLANJUTAN AKSI PERUBAHAN DAN DAMPAK PELATIHAN KEPEMIMPINAN PENGAWAS (PKP) TERHADAP PELAYANAN PUBLIK DI BPSDM PROVINSI KALIMANTAN BARAT
Authors: Zainuri Zainuri , Aswandi Zaniar
Published: November 2022

Fokus penelitian adalah evaluasi pasca Pelatihan Kepemimpinan Pengawas (PKP) di Badan Pengembangan Sumber Daya Manusia (BPSDM) Provinsi Kalimantan Barat (Kalbar) Tahun 2020. Variabel yang diteliti yaitu dampak PKP yang diselenggarakan BPSDM Provinsi Kalbar Tahun 2020. Penelitian menerapkan metode deskriptif, pendekatan kuantitatif serta desain evaluasi. Populasi mencakup seluruh alumni PKP tahun 2020 sebanyak 80 orang dengan teknik penarikan sampel total. Hasil penelitian menemukan aksi perubahan bermanfaat sangat baik bagi unit kerja serta berlanjut di jangka menengah dan panjang. Faktor utama pendukung keberhasilan adalah dukungan mentor/atasan. Faktor penghambat antara lain kurangnya dana dan sumber daya lain, terkendala tugas rutin dan rotasi project leader selama implementasi. Penelitian juga menunjukkan peningkatan kinerja sebagai dampak PKP membawa dampak yang positif pada peningkatan performa pelayanan publik.
Possibilities of GIS technologies for predictive detection of areas of solid flow discharge within water protection zones
Authors: Poletaev Arseniy
Published: November 2022

The article considers the modern possibilities of GIS technologies for monitoring the state of the soil cover and water erosion processes. The possibilities of using the Normalized Diference Vegetation Index (NDVI) to assess various types of vegetation cover are shown. The substantiation of the choice of a key site, which includes both water protection zones and landscape positions associated with them in terms of material and energy flows, is presented. A method for obtaining a vector layer of NDVI values calculated from 9 Sentinel-2 satellite images for the period from March to November 2021 is presented. NDVI values are classified and the cells of the vector layer are combined into classes. Methods for obtaining rasters (with formula reduction) of the Topographical Wetness Index (TWI) and the Stream Power Index (SPI) on the territory of a key area are presented. The vector layer of NDVI values was compared with the TWI and SPI rasters, as well as with the average daily air temperature values. The dynamics of NDVI values for March–November 2021 is shown in the key area, a schematic map of the vector layer of NDVI values, ranked by class, is shown. The calculation of the ratio of areas of different classes in the key area was carried out. Topographical Wetness Index (TWI) and Stream Power Index (SPI) rasters are shown. Examples of queries to databases of layers obtained as a result of intersection of vector layers are given: TWI and NDVI, SPI and NDVI. Schematic maps have been obtained based on a combination of NDVI, TWI, SPI values, showing potentially erosion-hazardous areas. When comparing the average daily air temperature values with the average NDVI values, it was found that the correlation between them is 0.89. Possible measures aimed at reducing the environmental load on the water protection zone are proposed.
Flood hazard on the rivers of the Northwestern Caucasus by spatial analysis according to precipitations and level observations in 2014–2020
Authors: Sheverdyaev Igor , Misirov Samir
Published: November 2022

The rivers of the North-Western Caucasus, despite the flood regime of runoff, until 2013 were not covered by regular observations of the water level. The network of automatic level gauges accumulated level observations every 10 minutes in 2014–2020. Spatial analysis tools were used to calculate the distribution of flood runoff velocities and the distribution of water runoff time on watersheds. Histograms of the distribution of watershed areas of level gauges by travel time were obtained and hydrographs for extreme precipitation were calculated using the example of July 6–7, 2012 in Krymsk. In the water level observation data, periods of level growth of more than 20 cm, accompanied by intense precipitation—4110 flood events at 69 level gauges, were identified. Flood cases are divided according to level growth into groups: up to 0.5 m, up to 1.0 m, up to 2.0 m and more than 2.0 m. The distribution of maximum daily precipitation according to ERA5-Land data for the watersheds of level gauges is considered. The calculated discharges and observations of the level showed that the highest discharges and high and frequent flood levels are observed on the rivers of the northern macroslope of the Caucasian watershed—rivers Abin, Shebsh and Pshish. On the southern macroslope, rivers are distinguished. Mezyb, Vulan, Pshada, Shapsho and Dzhubga, however, they are inferior to the watersheds of the northern macroslope. The scale and number of flood level rises in the northern watersheds (left tributaries of the Kuban River) increases from west to east and in accordance with the growth of the watershed area. In the southern watersheds, the trend is similar, but due to smaller watersheds in general, less noticeable. The highest value of the ratio of the maximum discharge to the total runoff is observed in the smallest watersheds, i.e. the most sudden floods are observed on them, however, due to the small catchment area, they do not form dangerous flood levels. A small number of flood events in the watersheds of the western part of the region is due to the nature of precipitation in 2012–2020 and small areas.
Hydrometeorological hazards during the winter periods in the Northern Caspian and dynamics under the influence of climatic changes
Authors: Magaeva Anastasiia , Yaitskaya Natalia
Published: November 2022

Hydrometeorological hazards of the Northern Caspian during the winter periods 1950–2020—due to climatic changes were investigated. Hydrometeorological hazards for the period 1950–2020 are considered: severe winter periods, early ice freeze-up, storm waves, wind surge, as well as cumulative hydrometeorological hazards—combinations of storm waves and surge. Geographic information system (GIS) “Ice regime of the southern seas of Russia” is the information basis for the study of the ice regime of the Caspian Sea.

Storm activity in the Caspian Sea were reconstructed using SWAN spectral wave model. Based on the cumulative freezing-degree days winters were divided by severity—mild, moderate and severe. During the study period, moderate types of winters prevail (59.4 %), and the number of severe and mild winters is the same and amounts to 14 pcs. (20.3 %) of each type. Due to climate change, the number of mild winters is increasing, and the number of severe ones is decreasing. Since 1985, 3 severe winters (2002/03, 2007/08, 2011/12) have been recorded. As a result, the ice cover area decreased by ∼7–10 %, and the duration of the ice season at the observation point Peshnoy was reduced by 5 days. 157 situations of combinations of storm surge and storm waves are identified: 140 are cases of potential situations of cumulative phenomena of a combination of storm and surge phenomena with a speed of 15 m/s or more of winds of effective directions. The largest number of cases of cumulative dangerous hydrometeorological hazards with a wind speed of more than 15 m/s is observed in March. After the 2000s there was an increase in the number of cases and duration of dangerous hydrometeorological hazards in November and March. A direct relationship between the number of cases of cumulative dangerous hydrometeorological hazards and the severity of winters has not been found.
Pengenalan Aplikasi Akuntansi Accurate bagi Guru Akuntansi SMK Xaverius 1 Palembang
Authors: Khairani Siti , Hartati Ery , Kusuma Dorie P. , Fransiska Julita
Published: November 2022

Perkembangan teknologi yang begitu cepat dan juga tuntutan dari dunia usaha yang ingin menyajikan laporan keuanga dengan cepat, handal dan akurat, maka kondisi ini mendorong para guru akuntansi agar mempunyai pengetahuan yang baik mengenai aplikasi ini agar dapat diajarkan kepada para siswa mereka. Untuk itu Tim Pengabdian Kepada Masyarakat STMIK GI MDP dan STIE MDP termotivasi untuk memberikan pelatihan accurate kepada para guru. Accurate adalah software akuntansi yang dikembangkan oleh PT Cipta Piranti Sejahtera atau yang dikenal dengan sebutan PT CPSSoft, yang mana aplikasi akuntansi ini dapat digunakan oleh berbagai perusahaan seperti Dagang, Jasa, Distributor, Kontraktor dan Manufaktur di Indonesia dari tahun 1998. Hingga saat ini versi terbaru dari accurate adalah Versi 5. Kelebihan aplikasi ini sangat banyak, selain userfreindly sistem akuntansi yang dibangun pada aplikasi ini sudah mengadopsi PSAK dan sistem perpajakan yang berlaku di Indonesia. Pelatihan dilaksanakan selama satu hari, yang dimulai dari pembuatan install aplikasi, input database perusahaan kemudian dilanjutkan praktik langsung menggunakan aplikasi ini untuk kasus perusahaan jasa dan dagang. Sharing discussion dengan pemateri dilakukan oleh para peserta secara antusias. Hasil program pengabdian kepada masyarakat ini dapat menambah pengetahuan dan skill para peserta pelatihan sehingga akan memperlancar proses pembelajaran di SMK Xaverius 1 Palembang.
Pemberdayaan Pekerja Kopi Petang melalui Pentingnya Pembelajaran Investasi
Authors: Juwita Ratna , P. Sri Megawati Elizabeth , Megawati Megawati
Published: November 2022

Pekerja merupakan aset bagi pemilik usaha di dalam pelaksanaan kegiatan usaha. Tanpa pekerja usaha tidak bisa berjalan dengan maksimal. Selain membutuhkan keahlian yang sesuai dengan kebutuhan pemilik usaha, para pekerja juga membutuhkan kemampuan di bidang pembelajaran investasi. Pemberdayaanpekerja diperlukan karena dengan adanya peningkatan kemampuan di bidang investasi. Baik investasi pendidikan, maupun investasi keuangan. Bentuk investasi ini bersifat jangka panjang, karena bisa meningkatkan kemampuan pendidikan pakoradan juga bisa meningkatkan kesejahteraan pekerja.