bluuebunny/crossref_metadata_2025 huggingface dataset:
INVESTIGATING THE PATH LOSS OF CELLULAR MOBILE NETWORK IN SUBURBAN AREAS OF BENIN METROPOLIS OF NIGERIA AT 910MHZ
Authors: Akhideno Itua O. , Eguasa Omo
Published: May 2023

This paper focuses on investigating path loss of mobile cellular network in suburban areas of Benin metropolis at a propagation frequency of 910MHz. The network Cell Info Lite application installed in GIONEE M5 CDMA was used to measure the received signal strength of the transmitted signal. The relative parameters were obtained from 100meters from the Glo base station from August, 2021 to October, 2021 within an average temperature of 270C. The results showed that Hata models are extensively used for the analysis of path loss evident in mobile cellular networks, GSM and CDMA system as depicted by the terrain of sub-urban areas of Benin City Metropolis. It was observed that the more the mobile stations move away from the base station, the higher the signal loss. This paper therefore guides cellular network service provider on accurate method of designing, deploying, and managing network to enhance good network coverage.
OCCURRENCE OF PARASITES IN LIVE Clarias gariepinus SOLD AT JIMETA MODERN MARKET, YOLA, ADAMAWA STATE
Authors: Idowu Thomas A. , James M. , Sajo Z. M. , Adedeji H. A. , Sogbesan O. A.
Published: May 2023

Fish is a cheap and important source of protein and minerals for humans. Clarias gariepinus accounts for over two-thirds of the fish consumed by an average Nigerian family. Various parasites infect C. gariepinus in the wild and in cultured environments, where they are captured and taken to various selling points to be sold to consumers. The present study is aimed at determining the occurrence of parasitic infection in live C. gariepinus from Jimeta Modern Market, Yola, Adamawa State, Nigeria. A total of 30 C. gariepinus were randomly bought from five different fish vendors, six from each. The fish were transported to the Department of Microbiology, Modibbo Adam University, Yola for further studies. The fish sexes were determined before they were examined for parasitic infections. Skin scrapings were obtained, and the gills were examined for ectoparasites while the gastrointestinal tracts were dissected and examined for endoparasites. Parasites were isolated and identified using standard parasitological procedures. Five classes of parasites were identified, namely, Nematode, Trematoda, Protozoa, Cestoda, and Hirudinea. The prevalence of parasites in C. gariepinus sampled from Jimeta Modern Market indicated 57.14% in the male C. gariepinus, while female C. gariepinus were infected with a prevalence rate of 42.85%. This study revealed some major groups of fish parasites that are of zoonotic importance.
CONVECTIVE HEAT AND CASSON NANOFLUID FLOW OVER A VERTICAL PLATE WITH HEAT SOURCE
Authors: Shied MomohJimoh Avidime , Oyem Anselm , Momoh Sheidu O. , Onojovwo Felix Tega
Published: May 2023

This paper considers the Casson nanofluid flow of a free convective heat transfer with heat source over a vertical plate and its thermophysical properties. The governing partial differential equations were reduced to couple nonlinear ordinary differential equations using similarity variables. The couple nonlinear ordinary differential equations were solved numerically using Runge-Kutta fourth order method with shooting technique and implemented using MatLab. The effects of various non-dimensional governing parameter namely, Prandtl number, Biot number, Grashof number, heat source parameter, skin-friction coefficient, Nusselt number and Sherwood number is analysed for Casson nanofluid flow, discussed and presented graphically. The result showed that heat source parameter increases in skin-friction coefficient, velocity and temperature profiles but, decreases in concentration profiles and Nusselt number.
PROGRESS IN NICKEL TARGET DESIGNS FOR DEUTERON IRRADIATION: A MILESTONE IN RADIOISOTOPE PRODUCTION OPTIMIZATION
Authors: Usman Ahmed Rufai , Lawal Ibrahim Abdullahi
Published: May 2023

Medical radioisotopes play significant roles in nuclear medicine, particularly in tumor diagnosis and its therapy. Optimization in production of these important isotopes is very essential for the overall health of the target patients. In this work, we analyzed general trends in the use of various forms of nickel metal as target for radioisotopes production in nuclear accelerators. A careful study of all previously used forms of nickel metal in the literature up to 2016 indicate that different physical forms of the metal, such as its very high purity and impure forms, alloys, compounds and powdered forms have, over the years, been used for various radioisotope productions under deuteron irradiation route, each providing different production effect. The excitation functions of several useful radioisotopes could be studied under deuteron irradiation of nickel. In a recent experimental work by the authors, some very pure, thin nickel foils of natural isotopic composition were also used in form of stacked arrangement for deuteron irradiation. The study found that most of the recent studies on radioisotopes production cross sections use very high purity and solid nickel forms.
SURVIVAL ANALYSIS OF BREAST CANCER PATIENTS IN KANO STATE
Authors: Nabegu Aminu Aliyu , Muhammad Musa Uba , Abdullahi Naziru
Published: May 2023

Cancer is a deadly malignant disease and is prevalent in Sub Saharan Africa. Specifically, breast cancer is now the most popular cancer and the second leading cause of death in Nigeria among women. This research is aimed at assessing the length of life of patients and prognostic factors associated with survival of breast cancer patients. Research subjects were breast cancer patients who went to Aminu Kano Teaching hospital (AKTH), patient’s follow-up data were obtained from the medical records and pathological variables were obtained from the department of Pathology from 2018- 2022. The survival analysis was performed using Kaplan Meier, log rank and Cox proportional regression model(semi-parametric). The Kaplan Meier results reveals the overall survival to be 0.75(75%). The median survival time is approximately 44 months, that is the probability that half of the patients have died. From the log-rank test, the survival times significantly differ across groups of Tumor stages, Age groups, Lymph node stages and Treatment Types. Results for the Cox proportional hazards model shows that, Treatment type and Tumor stage breast cancer were the risk factor for death in breast cancer patients. It was found that the hazard of death is twice or more for patients with a tumor characterized as tumor stage IV compared to other tumor stages. The hazard of death for patients on Radiotherapy treatment was 1.4 times as patients on Chemotherapy or Hormonal-therapy treatment. The Proportional Hazard assumption was assessed and all the variables meets the assumption.
COMPARATIVE PROXIMATE COMPOSITION, ANTI-NUTRITIONAL ANALYSES AND ANT-MICROBIAL SCREENING OF SOME NIGERIAN MEDICINAL PLANTS
Authors: Khan M. E. , Adebayo K. O. , Osigbemhe I. G. , Maliki M. , Bolaji A. M. , Paul F. , Edeeje J. P.
Published: May 2023

The food insecurity in the world/Nigeria paves the way for more research to remedy human hunger /diseases caused by weather conditions / greenhouse effects. This study compares and validates the proximate composition, the anti-nutritional and anti-microbial screening of crude methanol extracts of three Nigerian medicinal plants; Lactuca taraxacifolia; [ moisture (10.68 ± 00%), Ash (19.48 ± 0.03%), Crude fibre (39.16 ± 0.10%), Crude Protein (7.97± 0.03%), Lipid (11.77± 0.02%), Carbohydrate (29.91± 0.13%), Oxalate > Phylate > Tannin; the inhibition zones for the most effective concentration of 50 mg / mL : Staphylococcus. aureus 45.66 ± 0.00, Escherichia coli 49.40 ± 0.01,  Salmonella typhi 42.30 ± 0.00, Streptococcus faecalis 41.90 ± 0.01]. Aframomum melegueta; {Moisture (4.36 ± 0.04 %), Ash (6.75 ± 0.03%), Crude fibre (19.92 ± 0.11 %), Protein (5.48 ± 0.04 %), Crude fat (3.60 ± 0.13%), Carbohydrate (59.49 ± 004%), Tannin > Phylate > Oxalate; S. aureus 20.22 ± 0.01, E. coli 30.21 ± 0.30, S. typhi 15.24 ± 0.11, S. faecalis 15.61 ± 0.13} and Ocimum gratissimum; [Moisture (12.43 ± 0.22%), Ash (17.77 ± 0.04%), Fibre (19.91± 0.15%), Protein (1.92 ± 0.26%), Fat (11.80 ± 0.02%), Carbohydrate (42.63 ± 0.06%), Tannin > Phylate > Oxalate; S. aureus 35.03 ± 0.00, E. coli 34.22 ± 0.71, S. typhi 32.02 ± 0.01, S. faecalis 30.01 ± 0.42]. Considering the proximate analyses, it’s seen that, A. melegueta carbohydrates is the greatest followed by O. gratissimum, then L. taraxacifolia. Their anti-nuttherapeutics and nutrients, especially during this era of food
EVALUATING THE RISK FACTORS AFFECTING THE SURVIVAL TIME OF TB/HIV CO-INFECTED PATIENTS TO EARLY DEATH AT RASHID SHEKONI TEACHING HOSPITAL, JIGAWA STATE
Authors: Abdullahi Naziru , Nabegu Aminu Aliyu , Kani Ibrahim , Muhammad Musa Uba
Published: May 2023

Tuberculosis is a serious health threat, especially for people living with HIV. people living with HIV are more likely than others to become sick with TB. Worldwide TB is one of the leading courses of death among people living with HIV (CDC 2015). A retrospective cohort study was conducted in which all patients registered for TB/HIV at Rashid shekoni teaching hospital from 1st January 2017 to 31st December 2021. Kaplan Meier and log rank test were used to determine the survival pattern and the survival experience of two or more different groups. Cox regression was used to identify factors affecting the survival time of the patients. This study consists of 274 TB and HIV co-infected adult patient out of these 120 were died during the study period, and 154 were censored.it was found that massive death occurred at 1.3years of follow up period and the over roll median survival time was (56 months). the multivariate cox regression analysis indicated that an old age patient>39yrs, HIV+, low CD4 cell count<456, weight<42 were significant risk factors associated with death of TB/HIV co-infected patients.  In this study the death of TB/HIV adult co-infection was found to be very high at 1.3yr. The risk factors leading to early death of TB/HIV co-infection was associated with age, weight, HIV+ positive, CD4 cell count. The medical decision and policy makers should give these risk factors identified in this study more priority when implementing target improvement in the National TB and HIV program.
STUDIES ON THE MILK YIELD AND COMPOSITION OF LACTATING RED SOKOTO DOES FED GINGER (Zingiber officinale) AS FEED ADDITIVE
Authors: Ibrahim Umar Malumfashi , Abdu S. B. , Musa A. , Lakpini C. A. M.
Published: May 2023

A study was conducted to evaluate the effect of inclusion levels of ginger on milk yield and composition of Red Sokoto does. A total of twenty-eight (28) Red Sokoto does (RSD) weighing on the average 16.29 kg were used. The animals were randomly assigned to four diets, containing 0, 250, 500 and 750g/100kg diet levels of ginger respectively in a completely randomized design. Each of the animals were fed concentrate at 1.5% of body weight. Milk yield and composition were recorded. Udder and teats of each doe were washed with cotton wool soaked in disinfectant (Methylated spirit) and then they were hand-milked into sterilized containers and measured using calibrated cylinder. Milk samples were analyzed for total solids, fat and protein using infrared spectrophotometry. Ash content was determined after heating in a muffle furnace for 3 hours and the solids not fat content was calculated by difference. Results obtained showed that higher total milk yield of 360 liters was recorded in RSD fed diet containing 250 g ginger. All milk composition parameters (total solid, ash, fat, solid not fat and crude protein), were significantly affected (P<0.05) by ginger inclusion. Fat and crude protein contents were significantly affected (P<0.05) by lactation stages with their higher values (P<0.05) recorded in mid lactation stage (4.35% and 3.61%) respectively. Ash content recorded significantly higher value (P<0.05) in early lactation stage (1.05%). Ginger inclusion levels in the diets of RSD improved milk yield and milk composition.
SIMPLIFIED MECHANISTIC – EMPIRICAL ANALYSIS OF FLEXIBLE PAVEMENT
Authors: Awosanya D. O. , Murana A. A. , Olowosulu A. T.
Published: May 2023

Pavement stress-strain analysis is an ideal tool for analytical modelling of pavement behaviour and thus, constitutes an integral part of pavement design and performance evaluation. It is the fundamental basis for the mechanistic design theory. Predicting pavement response by simplified procedure analysis by relying on equivalency factors using axle load spectrum which is obtained from Weigh-In-Motion (WIM) data is aimed for this study. The framework for computing the structural response of the standard axle group loads on a pavement structure by using a layered elastic computer program and calculation of pavement responses for axle load distribution for different axle groups and axle types by using the theoretical analysis. From the study, the summary of the obtained results are as follows: (1) axle load distribution was developed for the four considered axle configurations; (2) Single axle with single tyre has the greatest destructive impact followed by the tridem axle with dual tyres (TRDT) and next by TADT. The least destructive axle group type is the Single Axle with Dual tyre SADT.The predicted pavement response by theoretical analysis indicates that the critical tensile strains obtained results are all greater than the critical vertical strains. At the heaviest axle load, from 70KN, for both SAST and SADT; from 140KN for TADT; and from 210KN, the critical strains have the greatest magnitude by SAST and followed by SADT and next by TADT. The least critical tensile strain is from the TRDT.
Pengaruh Visibilitas Media Dan Digital Bank Terhadap Pengungkapan Laporan Keberlanjutan Dengan Tata Kelola Sebagai Variabel Moderasi
Authors: Subagyo Bambang , Murwaningsari Etty
Published: May 2023

Penelitian ini bertujuan menguji pengaruh visibilitas media dan digital bank terhadap pengungkapan laporan keberlanjutan, serta pengaruh tata kelola dalam memoderasi hubungan visibilitas media dan digital bank terhadap pengungkapan laporan keberlanjutan. Populasi yang digunakan dalam penelitian ini adalah perusahaan sektor perbankan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2018-2021. Teknik pengambilan sampel menggunakan teknik purposive sampling dengan model analisis adalah model regresi berganda. Hasil penelitian menunjukkan bahwa visibilitas media dan digital bank berpengaruh negatif yang signifikan terhadap pengungkapan laporan keberlanjutan. Hasil penelitian menunjukkan bahwa tata kelola melalui komposisi komisaris independen memperkuat pengaruh positif ketika memoderasi pengaruh visibilitas media dan digital bank terhadap pengungkapan laporan keberlanjutan.
Interior Design Alphabet Incubator 3.0 Based on Planner 5D
Authors: Mertayasa I Komang , Rahardja Untung , Hardini Marviola , Harahap Eka Purnama
Published: May 2023

Membuat desain interior ruangan 3D membutuhkan proses yang panjang. Proses desain memainkan peran vital dalam menciptakan desain interior 3D yang cukup bagus. Dalam pengerjaan desain interior, permasalahan yang dihadapi adalah kapasitas ruangan dan tata letak objek yang akan ditempatkan. Maka dari itu, desain interior 3D dapat dilihat dari kualitasnya dan menarik bagi yang melihatnya. Terdapat permasalahan pada desain interior 3D yaitu objek terkunci, perlu beralih ke akun prabayar atau premium, tekstur yang terbatas saat menambahkan gambar dari perangkat, kapasitas ruang, dan tata letak objek. Penelitian ini membahas tentang bagaimana penggunaan aplikasi 5D planner dalam desain interior 3D yang berkaitan dengan prinsip dasar interior sederhana, sehingga peneliti mengolah aplikasi Planner 5D dalam desain interior 3D dan metode menggambar konvensional di ruang inkubator alfabet. Namun, penggambaran dilakukan dalam tiga tahap dalam pembuatan desain interior ini. Yaitu penataan 3D yang dibagi menjadi tiga area yaitu bidang objek dan pengaturan sudut pandang menggunakan aplikasi 5D planner.
Perancangan Sistem Task Management Pada CV. Balinet Intermedia Menggunakan MVC (Model-View-Controller)
Authors: Sulistyadewi Ni Putu , Sastrawangsa Gde , Wulandari Riza
Published: May 2023

Penerapan inovasi dari sisi teknologi menjadi langkah eksistensi sebuah perusahaan. Namun, pada CV. Balinet Intermedia proses manajemen tugasnya belum terintegrasi, seperti pencatatan, pembagian dan pelaporan tugas, sehingga pemantauan kinerja Divisi perusahaan belum optimal. Adapun tujuan dari penelitian ini adalah menyiapkan dokumen perancangan sistem task management untuk CV. Balinet Intermedia. Penelitian ini menggunakan Metode MVC (Model-View-Controller) untuk menguraikan tiga bagian utama pembangunan sistem yang bertugas untuk melakukan manipulasi data, menampilkan informasi kepada pengguna serta bagian yang mengontrol sistem, sedangkan untuk teknik pengumpulan data menggunakan Observasi, Wawancara dan Studi Literatur. Pada penelitian ini, perancangan sistemnya menggunakan Use Case Diagram, Diagram Konteks, dan Entity Relationship Diagram (ERD), lalu untuk perancangan model menggunakan Class Diagram Model serta Data Flow Diagram, sedangkan untuk perancangan controller menggunakan Class Diagram Controller. Sistem Task Management ini juga dilengkapi dengan fitur untuk mengelola data user, client, team, task, note, log login, submit task, verifikasi task, dan mencetak laporan task. Hasil kuesioner evaluasi kesesuaian rancangan dengan user menunjukkan skor rata-rata 89 point. Dengan demikian hasil dari penelitian ini adalah sebuah dokumentasi perancangan Sistem Task Management yang sudah sesuai dengan kebutuhan user, sehingga kedepannya dapat dijadikan sebagai panduan dalam proses implementasi sistem.

 

Kata kunci: CV. Balinet Intermedia, Task Management, Model View Controller, MVC
Implementasi Algoritma Apriori Untuk Prediksi Transaksi Penjualan Produk Pada Aplikasi Point Of Sales
Authors: Fathurrozi Ahmad , Masya Fajar , Sugiyatno
Published: May 2023

Dalam menghadapi persaingan pasar, untuk dapat meningkatkan penjualan produk yang dijual, pihak terkait harus memikirkan strategi pada pemasaran produk untuk dapat meningkatkan produktivitas penjualan. Salah satunya dengan memprediksi dan menganalisis data transaksi penjualan pada sistem Point of sales yang digunakan. Belum tersedianya analisa perhitungan dari pembentukan suatu pola asosiasi produk yang paling sering dibeli oleh konsumen pada data transaksi penjualan produk. Dengan penerapan teknik data mining pada metode association rule menggunakan algoritma apriori dapat sebagai metode untuk memprediksi dan menganalisis data dari transaksi penjualan, metode ini bertujuan untuk menampilkan informasi tentang hasil data berupa suatu pola asosiasi produk yang paling sering dibeli oleh konsumen. Dengan pola asosiasi produk yang dihasilkan tersebut akan digunakan untuk sebagaipendukung pengambilan keputusan dalam membuat solusi bisnis.
Existence and uniqueness of viscosity solutions to the infinity Laplacian relative to a class of Grushin-type vector fields
Authors: Bieske Thomas , Forrest Zachary
Published: May 2023

In this paper we pose the $\infty$-Laplace Equation as a Dirichlet Problem in a class of Grushin-type spaces whose vector fields are of the form
\begin{equation*}
X_k(p):=\sigma_k(p)\frac{\partial}{\partial x_k}
\end{equation*}
and $\sigma_k$ is not a polynomial for indices $m+1 \leq k \leq n$. Solutions to the $\infty$-Laplacian in the viscosity sense have been shown to exist and be unique in [3], when $\sigma_k$ is a polynomial; we extend these results by exploiting the relationship between Grushin-type and Euclidean second-order jets and utilizing estimates on the viscosity derivatives of sub- and supersolutions in order to produce a comparison principle for semicontinuous functions.
Análisis de Fragilidad de una de las Tipologías Estructurales más Relevantes de la Ciudad de Quito. Proyecto TREQ-GEM
Authors: Palacios Patricio , Celi Carlos
Published: May 2023

Esta investigación presenta los resultados de los análisis estáticos no lineales de las distintas combinaciones probables para la evaluación de la vulnerabilidad de estructuras de cuatro a seis pisos que tienen una forma irregular en planta con entrepisos de hormigón hecho en sitio y conformadas por pórticos rellenos con mampostería. Se obtuvieron curvas de capacidad teóricas y estas fueron sometidas a varios escenarios sísmicos definidos en la Norma Ecuatoriana de Construcción, para los periodos de retorno comprendidos desde 25 hasta 475 años en intervalos de 10 años, con variaciones de suelo tipo C y D. No se buscó determinar los modos de falla de la tipología sino el comportamiento global estructural, con el fin de utilizar esta información en los cálculos de riesgo del Distrito Metropolitano de Quito, con base en las curvas de fragilidad que se generaron. Las curvas de fragilidad mostraron que para un control basado en la deriva máxima permitida por la Norma Ecuatoriana de Construcción del 2%, se presentaron probabilidades predominantes del 95% de igualar o exceder el límite de daño completo, por lo que se busca concientizar sobre las intervenciones estructurales pre-evento sísmico, como reforzamientos o estrategias de mitigación de daño por parte de las autoridades gubernamentales.
Estudio de Mezclas Ácido Poliláctico – Almidón de Achira Compatibilizadas con Polivinil Alcohol
Authors: Molina Pamela , Silva Gabriela , Valle Vladimir , Aldás María-Belén , Proaño Erick
Published: May 2023

Se prepararon mezclas ácido poliláctico (PLA) – almidón de achira empleando polivinil alcohol (PVA) y glicerol como compatibilizante y plastificante, respectivamente. Las mezclas fueron caracterizadas en términos de espectroscopia infrarroja por transformadas de Fourier (FTIR), calorimetría diferencial de barrido (DSC), y propiedades mecánicas. Las superficies de fractura obtenidas del ensayo de tensión fueron evaluadas por medio de microscopía electrónica de barrido (SEM). Adicionalmente, se determinó la biodegradabilidad de las mezclas por medio de ensayos en suelo natural, vermicomposteo, así como también en condiciones aerobias y anaerobias. De acuerdo con los resultados, el PVA incrementó la resistencia a la tensión, elongación a la rotura y produjo una disminución en el módulo de Young. Las imágenes SEM exhibieron superficies rugosas con gránulos de almidón. Adicionalmente, los resultados de DSC evidenciaron un solo valor de Tg, muy cercana a la Tg de los componentes solos; en tanto que los espectros FTIR sugirieron la presencia de enlace hidrógeno entre PLA y almidón. Finalmente, los resultados de vermicomposteo revelaron un alto nivel de degradación de las mezclas PLA – almidón de achira.
Elementos Reusables para Experimentar con Metodologías Basadas en Estrategias y Patrones de Privacidad
Authors: Caiza Julio , López Gabriel , Guamán Danny
Published: May 2023

En línea con el avance global, la región latinoamericana ha establecido legislaciones que buscan establecer orden en un contexto donde la explotación de los datos personales y la protección de la privacidad de las personas son de gran relevancia. Uno de los mecanismos establecidos para alcanzar tal orden es la Protección de Datos desde el Diseño de los sistemas. Para materializarlo, los investigadores en el dominio han enfocado muchos esfuerzos en los patrones de privacidad, en metodologías basadas en ellos y en las estrategias de diseño. Sin embargo, el estado del arte señala que hace falta evidencia empírica para validar su aplicación y utilidad. Asimismo, señala la complejidad para llevar a cabo experimentos que provean dicha evidencia. El objetivo de este trabajo es contribuir a la obtención de evidencia empírica y realizar un análisis de las metodologías que hacen uso de patrones de privacidad y de estrategias de diseño para definir un conjunto de elementos que puedan ser reusados al realizar experimentos. Para ello, hemos revisado la literatura, siguiendo un conjunto de pasos sistematizados y un proceso de bola de nieve, en busca de metodologías basadas en patrones y estrategias de diseño. A partir de los resultados se observa que las estrategias de diseño de Hoepman son las más aceptadas y que hay tres enfoques de metodologías que hacen uso de ellas. En estos enfoques, se identifican elementos que podrían ser reusables al plantear experimentos: estrategias, subestrategias, patrones de privacidad, PETs, relaciones y sistemas de patrones.
Flux Surfaces According to Killing Magnetic Vectors in Riemannian Space $\mathbb{S}ol3$
Authors: BENMENSOUR Nourelhouda , HATHOUT Fouzi
Published: May 2023

In this paper, we define flux surface as surfaces in which its normal vector is orthogonal to the vector corresponding to a flux with its associate scalar flux functions in ambient manifold M. Next, we determine, in 3-dimensional homogenous Riemannian manifold $\mathbb{S}ol3$, the parametric flux surfaces according to the flux corresponding to the Killing magnetic vectors and we calculate its associate scalar flux functions. Finally, examples of such surfaces are presented with their graphical representation in Euclidean space.
The future of acupuncture education: 3D Augmented Reality (AR) acupuncture model for Chinese Medicine
Authors: TONG Carrison K S , CHAN Oliver C M , YU Edwin C L
Published: May 2023

Acupuncture is a therapeutic modality in Traditional Chinese Medicine which aims to improve the flow of Qi (chi) or energy around the body by applying needles to specific points on the skin. Traditional Chinese Medicine teaches that Qi must flow freely through the body’s meridians, or channels, to ensure health and well-being. Traditionally, Chinese Medicine practitioners used a wooden, copper or bronze acupuncture model to show the points where needles should be applied to the skin and the meridians through which Qi flows around the body. However, as traditional models depict acupuncture points which are too rigid for teaching purposes, understanding the descriptions of acupuncture points from textbooks in 2D is also another hurdle for beginners to apply them to the human body in 3D. With modern computing and 3D-printing technologies, this article introduces a realistic human model in the form of a 6-foot copper acupuncture sculpture with over 370 virtual acupuncture points using state-of-the-art Augmented Reality (AR) and metal 3D-printing techniques for enhanced teaching, learning, and demonstration of acupuncture principles. It will be a new training model for Western and Chinese medical practitioners as well as for the public to gain interactive acupuncture experience that is beneficial to their own health.
Alaska deep-sea coral and sponge assemblages are well-defined and mostly predictable from local environmental conditions
Authors: Sigler MF , Rooper CN , Goddard P , Wilborn R , Williams K
Published: May 2023

Vulnerable marine ecosystems (VMEs), including deep-sea corals and sponges, are important habitats for many fish and invertebrate species and are at risk from the effects of fishing, seafloor mining, and climate change. We describe the zoogeography of deep-sea corals and sponges in Alaska, USA, and identify the environmental factors structuring these assemblages. Images were collected with a calibrated stereo drop-camera (n = 853 transect locations). We used cluster analysis to identify assemblages, canonical correspondence analysis to identify the primary environmental variables structuring these assemblages, and random forest and generalized additive modeling to predict their spatial distributions. The 6 identified assemblages were well defined, with each dominated by a single indicator taxon (2 coral taxa: Primnoidae, Stylasteridae; 2 sponge taxa: Demospongiae, Hexactinellida; 2 sea whip/pen taxa:Balticinasp.,Ptilosarcus gurneyi). The most common assemblages were Demospongiae, Primnoidae, andBalticinasp. Primnoidae and Demospongiae were positively influenced by greater maximum tidal current, bottom current, and bottom temperature as well as proportion of rock and cobble (high for Primnoidae; low to medium for Demospongiae).Balticinasp. was influenced in the opposite direction and was aligned along lower maximum tidal current, bottom current, and bottom temperature as well as unconsolidated sediment and greater depth. We defined VME community indicators as the 6 assemblages, each dominated by a single indicator taxa. These VME community indicators can guide the identification of protected areas.
PEMULIHAN EKONOMI PASCA COVID-19 MELALUI PENGEMBANGAN USAHA MIKRO, KECIL, DAN MENENGAH (UMKM) PRODUK OPAK
Authors: Fitri Ahmad Asrof , Sajali Munawir , Fitria Laela Nurul , Jaiz Irfan Amirul , Ardi Zian Ikhsaniyah
Published: May 2023

Covid-19 had given negative effect to all of sectors of human life, particularly in health and economy. In economy sector, the most people affected by covid was workers and those who had micro, small and medium enterprises (MSMEs). In rural area, impact of covid-19 had grown broader by declining people's purchasing power. Inhabitant of Mekarsari village, located in Gantar district in Indramayu City, West Java, for instance, suffered financial loss. Traditional method of marketing and selling was unable to adapt to new behavior of market. The program is based on previous community service program, which was only focused on production. For the reason previously mentioned, this article discusses marketing and production learning program for Opak products is carried out through online media. The methods used in this program are 1) organizing a workshop on digital marketing, 2) making product labels and branding, 3) taking a part in marketing process of Opak. The result showed that the program had significant role in rebranding the product.
Assessment of Anatomical Variation of Styloid Process in Multidetector Computed Tomography
Authors:   Assistant Professor, National Academy of Medical Science, National Trauma Center, Kathmandu, Nepal., Rokka Damodar , Chaudhary Ajay Kumar ,   Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Published: May 2023

Objective: This study aimed to assess the anatomical variation of the styloid process of Nepalese individuals by using multi-detector computed tomography scans. It was carried out to establish the baseline for the normal length of the styloid process and to compare the variability of styloid process measurement between different age group and gender. Materials and methods: This quantitative, cross-sectional was performed in the Department of Radiology and Imaging, Tribhuvan University Teaching Hospital. Imaging data were collected over the period of January to April 2021 with the total number of 153 individuals. The age and gender of the individuals were noted. The measurement was done in the Multiplanar Reconstruction (MPR) coronal sections of Head and Neck, PNS and Cerebral Angiography. Various Styloid Process (SP) morphology parameters like RLSP, RGSP, LLSP, LGSP, Right Elongation Type, Right Calcification Type, Left Elongation Type, and Left Calcification Type was measured. Results: The measurement of the length of SP was found to be 3.06±0.72 cm (ranged 1.80-5.54 cm) in right SP while that of left SP was 3.08±0.72 cm (ranged 1.45-5.69 cm). The gap between the SP and the calcification pattern was found to be 0.51±0.30 cm (ranged 0.08-1.20 cm) in right SP while that of left SP was 0.63±0.43 cm (ranged 0.08- 1.97cm). Similarly, there was a statistical significant difference between the RLSP-RGSP and LLSP-LGSP. The length of styloid process was found to be higher among male than in female. But there was no statistical significant difference between male and female in the SP measurement. The series of elongation patterns were found to be normal SP, followed by elongated, distant elongated, pseudoarticulated, and segmented SP. The series of calcification patterns were found to be calcified SP, followed by nodular, partial, and outlined SP. Conclusion: In this study, the valuable information regarding anatomical length and variation of styloid process with respect to age and gender among the Nepalese individuals was found. 3D CT reconstruction is a gold standard investigation that helps in studying the relation of the SP with surrounding structures.
Reading-Idioms (de la poussance)
Authors: Kamuf Peggy
Published: May 2023

This essay traces the figure of the ‘leap’ in the second year of Derrida’s Beast and the Sovereign seminar, where it crosses in a significant way the central concern with Walten in Heidegger’s thought. A key question for the reading is about the impulse, drive or push behind all these leaps. Precipitated out is a notion that names what is neither subject nor object, action nor passion, but de la poussance, a noun forged on the model of those third-voice substantives like différance, aimance, and arrivance that Derrida deployed all across his work.
Correction of psychoemotional disorders and quality of life in patients with eczema using janus kinase inhibitor
Authors: Novikova L. A. , Dontsova E. V. , Chernov A. V. , Kruglova L. S. , Saurina O. S. , Dontsov V. G. , Borzunova L. N. , Pogodaeva T. I.
Published: May 2023

Objective. To evaluate the effectiveness of upadacitinib for improving the quality of life and correcting psycho-emotional disorders in patients with eczema.

Material and methods. The study included 64 patients with eczema (mean age 58.5 ± 3.4 years, men – 43, women – 21), randomized into two groups. Patients of group 1 (n = 33) received basic drug therapy (BDT), group 2 (n = 31) – in addition to BDT, the Janus kinase 1 inhibitor upadacitinib (UPA) 15 mg per day for 2 months. The values of the patients' dermatological symptom scale index (DISS), Dermatology Life Quality Index (DLQI), anxiety, depression, functional state of patients on the WAM (wellbeing, activity, mood) scale were evaluated in dynamics after 2 months after the start of treatment.

Results. In the BDT group, the value of DISS in patients after 2 months from the start of treatment decreased by 1.33 times, while in the UPA + BMT group it decreased by 2.17 times. In the BDT group, the DLQI index decreased by 1.26 times, while in the UPA + BDT group – by 1.66 times. The level of anxiety in patients in the BDT group decreased by 1.34 times, in the UPA + BDT group – by 1.64 times. The level of depression in the BDT group decreased by 1.22 times, in the UPA + BDT group – by 1.67 times. Indicators of the functional state of the WAN scale in patients with BMT increased only by 1.06, 1.03, 1.05 times, and in the UPA + BMT group, respectively, 1.4, 1.5, 1.6 times.

Conclusions. BDT, while improving the clinical status of patients, at the same time has an insufficient corrective effect on the severity of anxiety, depression, WAM indicators and a reduced quality of life. Additional appointment of upadacitinib to patients was accompanied by a more pronounced positive effect on the levels of anxiety, depression, indicators of the functional state of patients, which contributed to an improvement in the quality of life compared to the results of BDT.
Methods for assessing severity of disease in congenital epidermolysis bullosa in children
Authors: Matushevskaya E. V.
Published: May 2023

Clinical methods for assessing the severity of the condition in epidermolysis bullosa are the most accessible means at the first stage of diagnosis, help to establish a clinical diagnosis, substantiate the need of consultations of specialists, and optimize the subsequent routing of the patient. In addition, the availability of tools helps to validate data, consistently assess the severity of the disease and record the therapeutic response in randomized trials of new pathogenetic treatments.
Use of injection methods in genitourinary syndrome of menopause
Authors: Avin М. , Surkichin S. I.
Published: May 2023

Genitourinary syndrome of menopause (GSM) is a set of symptoms of atrophy, the main cause of which are evolutive changes in the vulvovaginal and urethral regions. GSM is a common condition affecting up to 90 % of menopausal women. The main symptoms encountered in this syndrome include: dryness of the vulvovaginal area (more than 90 %), dyspareunia (78 %), itching (57 %) and burning (57 %). These symptoms, according to various questionnaires, strongly affect the quality of women’s life, as well as their sexual life. A review of GSM therapy with plasma therapy (PRP) and injection with hyaluronic acid was performed. The clinical observation and the process of managing patients with manifestations of GSM are described in detail. An analysis of the effectiveness and safety of injection techniques in GSM is considered.
Usage of thread implantology and injection technologies in cosmetology
Authors: Serov D. N. , Rubtsova L. A.
Published: May 2023

For the past years, there have been lots of minimal invasive methods developed regarding to the anti-aging therapy, and, according to practical experience, many of them can be safely and effectively combined. Complex approaches in patients’ treatment allow to achieve the most optimal results. In this work we described issues of effective combinations of thread implantology and injection technologies, safety of these combinations, performance efficacy and algorithms for the case management.
A Systematic Review and meta-analysis of Intervention on Social cognition in preschool Children With Autism Spectrum Disorder
Authors:   Korean Association For Persons With Autism, Kim Da-hye , Choi Eun-sil
Published: May 2023

Objective: We conducted a systematic review and meta-analysis of interventions for social cognition in preschool children with autism spectrum disorder and aimed to provide evidence regarding occupational interventions.
Methods: The studies included in this review were collected by searching the PubMed, Scopus, ProQuest Health & Medical Collection (PML), and PsycARTICLES databases as well as two trial registries. We searched the databases and registries for articles from January 2013 to January 2023 using the following search strategy: [(autis*) AND (“social cognitive” OR “social cognition”) AND (Intervention or therapy or approach or treatment or training)]. A total of 3 studies were included in the analysis.
Selection criteria: The studies included in the review were selected if they reported on an applicable intervention for social cognition, presented randomized controlled trial data, and included participants who had a confirmed diagnosis of autism spectrum disorder. The interventions for social cognition were analyzed using descriptive analysis, and the effects of the interventions were meta-analyzed using the ReviewManager (RevMan) 5.4 program.
Results: Three randomized controlled trials involving 378 participants were included. The Intervention program that includes social cognitive components for preschool children with autism spectrum disorder resulted in an increase in social cognition and functional play skills.
Conclusion: Through this systematic review, we were able to identify and understand the effect of interventions on social cognition in preschool children with autism spectrum disorder. Further research is required on the need for accessible diagnosis, improving the quality and diversity of early intervention services, and policies for effective intervention provision.
Taste This Score
Authors: Rosales Eliana
Published: May 2023

Digital scores were introduced in contemporary music some decades ago, as well as extra-musical images and visual signs in music writing. What is not yet explored and seems to be a very fertile field of research is musical writing based on research on transmodality. This article presents an investigation on some of the possibilities of musical and sonic writing through the incorporation of images of food textures. This is part of more extensive work that includes research on sonic relationships with visual textures (not only food) and that also investigates the compositional and performative possibilities of transmodal digital dynamic scores (video scores).
Editorial: caminhos investigativos da música ubíqua, gastrossônica e bem-estar
Authors: Keller Damián , Alcântara-Silva Tereza Raquel , Mesz Bruno Alejandro
Published: May 2023

Editorial para o dossê “Ubimus, Gastrossônica e Bem-estar” ocorrido de forma online em 2022 via Universidade Estadual do Paraná. Editores convidados: Damián Keller (Universidade Federal do Acre, Universidade Federal da Paraíba, Brasil), Tereza Raquel Alcântara-Silva (Universidade Federal de Goiás, Brasil), Bruno Mesz (Universidad Nacional de Tres de Febrero, Argentina)
Falácias, pós-verdade e ensino-aprendizagem de Ciências
Authors: Brabo Jesus Cardoso
Published: May 2023

Inicialmente este texto traça um breve panorama da dinâmica e efeitos perniciosos da atual proliferação de fake news e teorias pseudocientí­ficas baseadas em falácias e outros tipos de estratagemas retóricos que, sistematicamente, vem disseminando ódio e preconceito à minorias e instigando atitudes negacionistas em relação à ciência, à razão e à democracia. Em seguida, discorre sinteticamente sobre a irônica apropriação discursiva de algumas teses relativistas por pseudointelectuais conservadores. Também discute o grau de penetração dessas mesmas teses na área de ensino de ciências e as possí­veis implicações educacionais de uma eventual adesão generalizada a tais pressupostos. Por fim, apresenta algumas observações metodológicas direcionadas aos que se dedicam à pesquisas na área de ensino e uma sugestão didática para tentar mitigar alguns problemas de alfabetização cientí­fica de estudantes, ocasionados pela insuficiência de práticas de análise crí­tica de textos acadêmicos ou de divulgação cientí­fica nas atividades escolares.
New metrics for multiple testing with correlated outcomes
Authors: Mathur Maya B. , VanderWeele Tyler J.
Published: May 2023

When investigators test multiple outcomes or fit different model specifications to the same dataset, as in multiverse analyses, the resulting test statistics may be correlated. We propose new multiple-testing metrics that compare the observed number of hypothesis test rejections (θ^) at an unpenalized α-level to the distribution of rejections that would be expected if all tested null hypotheses held (the “global null”). Specifically, we propose reporting a “null interval” for the number of α-level rejections expected to occur in 95% of samples under the global null, the difference between θ^ and the upper limit of the null interval (the “excess hits”), and a one-sided joint test based on θ^ of the global null. For estimation, we describe resampling algorithms that asymptotically recover the sampling distribution under the global null. These methods accommodate arbitrarily correlated test statistics and do not require high-dimensional analyses, though they also accommodate such analyses. In a simulation study, we assess properties of the proposed metrics under varying correlation structures as well as their power for outcome-wide inference relative to existing methods for controlling familywise error rate. We recommend reporting our proposed metrics along with appropriate measures of effect size for all tests. We provide an R package, NRejections. Ultimately, existing procedures for multiple hypothesis testing typically penalize inference in each test, which is useful to temper interpretation of individual findings; yet on their own, these procedures do not fully characterize global evidence strength across the multiple tests. Our new metrics help remedy this limitation.
MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues
Authors: Lim Mark J. , Yagnik Gargey , Henkel Corinna , Frost Signe F. , Bien Tanja , Rothschild Kenneth J.
Published: May 2023

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is one of the most widely used methods for imaging the spatial distribution of unlabeled small molecules such as metabolites, lipids and drugs in tissues. Recent progress has enabled many improvements including the ability to achieve single cell spatial resolution, 3D-tissue image reconstruction, and the precise identification of different isomeric and isobaric molecules. However, MALDI-MSI of high molecular weight intact proteins in biospecimens has thus far been difficult to achieve. Conventional methods normally require in situ proteolysis and peptide mass fingerprinting, have low spatial resolution, and typically detect only the most highly abundant proteins in an untargeted manner. In addition, MSI-based multiomic and multimodal workflows are needed which can image both small molecules and intact proteins from the same tissue. Such a capability can provide a more comprehensive understanding of the vast complexity of biological systems at the organ, tissue, and cellular levels of both normal and pathological function. A recently introduced top-down spatial imaging approach known as MALDI HiPLEX-IHC (MALDI-IHC for short) provides a basis for achieving this high-information content imaging of tissues and even individual cells. Based on novel photocleavable mass-tags conjugated to antibody probes, high-plex, multimodal and multiomic MALDI-based workflows have been developed to image both small molecules and intact proteins on the same tissue sample. Dual-labeled antibody probes enable multimodal mass spectrometry and fluorescent imaging of targeted intact proteins. A similar approach using the same photocleavable mass-tags can be applied to lectin and other probes. We detail here several examples of MALDI-IHC workflows designed to enable high-plex, multiomic and multimodal imaging of tissues at a spatial resolution as low as 5 µm. This approach is compared to other existing high-plex methods such as imaging mass cytometry, MIBI-TOF, GeoMx and CODEX. Finally, future applications of MALDI-IHC are discussed.
Bacteria associated with glioma: a next wave in cancer treatment
Authors: Meng Yiming , Sun Jing , Zhang Guirong , Yu Tao , Piao Haozhe
Published: May 2023

Malignant gliomas occur more often in adults and may affect any part of the central nervous system (CNS). Although their results could be better, surgical excision, postoperative radiation and chemotherapy, and electric field therapy are today’s mainstays of glioma care. However, bacteria can also exert anti-tumor effects via mechanisms such as immune regulation and bacterial toxins to promote apoptosis, inhibit angiogenesis, and rely on their natural characteristics to target the tumor microenvironment of hypoxia, low pH, high permeability, and immunosuppression. Tumor-targeted bacteria expressing anticancer medications will go to the cancer site, colonize the tumor, and then produce the therapeutic chemicals that kill the cancer cells. Targeting bacteria in cancer treatment has promising prospects. Rapid advances have been made in the study of bacterial treatment of tumors, including using bacterial outer membrane vesicles to load chemotherapy drugs or combine with nanomaterials to fight tumors, as well as the emergence of bacteria combined with chemotherapy, radiotherapy, and photothermal/photodynamic therapy. In this study, we look back at the previous years of research on bacteria-mediated glioma treatment and move forward to where we think it is headed.