bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Monitoring of Weekly IGF-I Levels During Growth Hormone Therapy With Once-Weekly Somapacitan
Authors: Juul Kildemoes Rasmus , Højby Rasmussen Michael , Agersø Henrik , Overgaard Rune Viig
Published: December 2020

Context

Somapacitan is a long-acting growth hormone (GH) in development for once-weekly treatment of GH deficiency (GHD). Optimal monitoring of insulin-like growth factor-I (IGF-I) levels must account for weekly IGF-I fluctuations following somapacitan administration.

Objective

To develop and assess the reliability of linear models for predicting mean and peak IGF-I levels from samples taken on different days after dosing.

Design

A pharmacokinetic/pharmacodynamic model was used to simulate IGF-I data in adults and children following weekly somapacitan treatment of GHD.

Setting and Patients

39 200 IGF-I profiles were simulated with reference to data from 26 adults and 23 children with GHD.

Intervention(s)

The simulated dose range was 0.02 to 0.12 mg/kg for adults and 0.02 to 0.16 mg/kg for children. Simulated data with >4 average standard deviation score were excluded.

Main Outcome Measure(s)

Linear models for predicting mean and peak IGF-I levels based on IGF-I samples from different days after somapacitan dose.

Results

Robust linear relationships were found between IGF-I sampled on any day after somapacitan dose and the weekly mean (R2 > 0.94) and peak (R2 > 0.84). Prediction uncertainties were generally low when predicting mean from samples taken on any day (residual standard deviation [RSD] ≤ 0.36) and peak from samples taken on day 1 to 4 (RSD ≤ 0.34). IGF-I monitoring on day 4 and day 2 after dose provided the most accurate estimate of IGF-I mean (RSD < 0.2) and peak (RSD < 0.1), respectively.

Conclusions

Linear models provided a simple and reliable tool to aid optimal monitoring of IGF-I by predicting mean and peak IGF-I levels based on an IGF-I sample following dosing of somapacitan. A short visual summary of our work is available (1).
11-Oxygenated Androgens Useful in the Setting of Discrepant Conventional Biomarkers in 21-Hydroxylase Deficiency
Authors: Jha Smita , Turcu Adina F , Sinaii Ninet , Brookner Brittany , Auchus Richard J , Merke Deborah P
Published: December 2020

Context

Serum 17-hydroxyprogesterone (17OHP) and androstenedione (A4) are the conventional biomarkers used to assess disease control in patients with 21-hydroxylase deficiency (21OHD). However, discrepancy between the two is not uncommon, limiting interpretation.

Objective

To evaluate 11-oxyandrogens in discriminating good versus poor disease control in 21OHD in the setting of discrepant 17OHP and A4.

Methods

Retrospective analysis of 2738 laboratory assessments obtained as part of Natural History Study of congenital adrenal hyperplasia (CAH) at the National Institutes Health Clinical Center. Patients with discrepant 17OHP and A4 and available sera were selected. A 15-steroid mass-spectrometry panel was performed in sera from patients with 21OHD and age- and sex-matched controls. Patients were categorized in “good” or “poor” control based on clinical assessment (bone age advancement, signs and symptoms of precocious puberty, menstrual irregularity, hirsutism, or hypogonadotrophic hypogonadism).

Results

Discrepant 17OHP and A4 was found in 469 (17%) laboratory assessments. Of these, 403 (86%) had elevated 17OHP with A4 in reference range. Of 46 patients with available sera, 30 (65%) were in good control. Median fold elevation relative to controls was higher in patients with poor versus good control for 11-hydroxytestosterone (median [interquartile range], 2.82 [1.25-5.43] vs 0.91 [0.49- 2.07], P = .003), and 11-ketotestosterone (3.57 [2.11-7.41] vs 1.76 [1.24-4.00], P = .047). Fold elevation of 11-hydroxytestosterone between 3.48 (sensitivity 97%, specificity 47%) and 3.88 (sensitivity 100%, specificity 40%) provided the best discrimination between poor vs good control.

Conclusion

11-Oxyandrogens, especially 11-hydroxytestosterone, may be useful in the management of CAH when conventional biomarkers are inconclusive.
Development of the Student’s Educational Independence in the Course of Designing His Individual Educational Route
Authors: Kazanceva Elena , Zhdanova E.
Published: December 2020

The authors of the article substantiate the relevance of expanding the term “educational independence” to the concept of “educational

independence”, which is proposed for use in primary school didactics. Educational independence, in contrast to educational independence, is not limited to educational situations, but also manifests itself in arbitrary cognitive activity, which meets modern requirements for learning outcomes, regardless of its period. However, when characterizing educational independence, it is necessary to take into account the individual capabilities of children of primary school age. As an effective means of developing educational independence, the article considers the construction of an individual educational route for a younger student, analyzes the process of its development using the Moodle distance learning system, which includes four stages: diagnostic, design, technological and evaluation. The sequence of joint actions of a teacher and a student to draw up a map of his individual educational route within the framework of a separate academic subject is given.
Multimedia Educational Presentations for Independent (Autonomous) Work of Younger Students
Authors: Bulycheva N. , Savochkina E. , Shtil'man N.
Published: December 2020

The article reveals the possibilities of using multimedia educational presentations as a means of methodological support of the distance

educational process in primary school. It is emphasized that multimedia educational presentations are considered by the authors only as an

emergency alternative to traditional education, in conditions when there is a need for a general temporary transition to its distance form. The

problems of organizing distance learning, which are especially relevant for primary school, and the ways of their solution with the help of

multimedia educational presentations, which are able to stimulate independent (autonomous) work of primary schoolchildren with minimal

involvement of adult family members, are identified. The requirements for a multimedia educational presentation are given, which correspond

to the recommendations of the Ministry of Education of the Russian Federation for mastering the Basic educational program of an elementary

school, as well as its characteristics and an algorithm for creating. The description of the multimedia educational presentation on the subject

“Literary reading” for the lesson in the distance mode is given.
A person-centred communication approach to working with older people who have dementia
Authors: Coleman Deborah June , Asiri Nawal Ali S
Published: December 2020

Dementia is prevalent among the older population, especially people over 65 years, and is characterised by deterioration in a person's cognitive abilities ( NHS, 2017 ). The main signs and symptoms of dementia include loss of memory, impaired thinking and problem-solving skills, and difficulties with communication. Effective communication in the healthcare setting will ensure patient care is safe and enable support workers to understand the needs of the older person with dementia. Communication is a vital aspect of healthcare, making it essential for support workers to be aware of challenges that may hinder communication and to identify strategies to enable the person to communicate their needs for as long as possible.
COVID-19, coagulopathy and clotting abnormalities
Authors: Robertson Deborah
Published: December 2020

Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
Achieving and maintaining competency as a nurse independent non-medical prescriber
Authors: Wright Liam , Jokhi Rachel
Published: December 2020

Prescribing practice within the United Kingdom has evolved, with many non-medical healthcare professionals holding or requiring prescribing rights as part of their role. This article outlines how the competencies of a nurse independent non-medical prescriber are achieved and maintained. It aims to inform prospective nurse independent non-medical prescribers and their organisations what is expected of during Independent Non-Medical Prescriber training and what their responsibilities will be to maintain competencies when qualified. The Competency Framework for all Prescribers is highlighted throughout the article for its essential role in Independent Non-Medical Prescriber training and practice.
Desigualdades sociales y trayectorias de rendimiento académico en niños y niñas de la ciudad de Córdoba, Argentina
Authors: DEGOY EMILSE , BERRA SILVINA
Published: December 2020

En un contexto de pobreza pero de alta tasade escolarización, se examina si existen diferentes trayectorias de rendimiento académico (RA) asociadas acaracterísticas socioeconómicas en niños/as de Córdoba-Argentina. Se realizó un estudio de cohortes prospectivas con escolares, en el que se obtuvieron mediciones anuales del rendimiento académico y medicionesbasales de características sociales: sexo, escolaridadmaterna, estrato ocupacional, nivel socioeconómico(NSE) y capacidad intelectual (CI). Se definieron cuatrotrayectorias de RA a partir de las calificaciones en Lengua y Matemática obtenidas por los/as niños/as al inicioy final del seguimiento, y su condición de Promovidos/No promovidos en cada ciclo lectivo: distinguida, satis-

factoria, regular, insatisfactoria. Se utilizaron modelos deregresión logística binomial y multinomial para examinarla presencia de desigualdades sociales. Se encontrarondiferencias significativas en la trayectoria de RA segúnlas variables socioeconómicas estudiadas cuyo efectono fue independiente de la capacidad intelectual. A suvez, la capacidad intelectual se vio fuertemente asociadacon la escolaridad materna, estrato ocupacional y NSE.Se corrobora la presencia de desigualdades sociales enla CI y las trayectorias de rendimiento académico delos escolares.
El trabajo colaborativo en red interinstitucional como experiencia de profesionalización y modo de abordar la educación en pandemia
Authors: GALFRASCOLI ADRIÁN , VEGLIA SILVIA , LOPEZ VERÓNICA , ASTESANA SILVANA , HAESLER NATALIA , LAMPERT ADRIANA , POLLA WANDA
Published: December 2020

Este artículo expone la experiencia en reddesarrollada por formadores de formadores del campode las Ciencias Naturales, de seis Institutos de Educación Superior de la provincia de Santa Fe, durante elperíodo de aislamiento social preventivo y obligatorio,debido a la pandemia de COVID-19. La suspensión delas actividades de enseñanza en los espacios físicostradicionales y la irrupción del modelo de educación adistancia, como alternativa para dar continuidad a losprocesos formativos en el Nivel Superior, supuso unacontecimiento al que hubo que hacer frente. El desconcierto de los primeros días dio paso a una iniciativacolectiva, plural y de cooperación, enmarcada en unproyecto de investigación, mediante el trabajo colaborativo en red que impidió que quedáramos entrampadospor la inmovilidad. El trabajo, desarrollado completamente gracias a las tecnologías digitales de comunicación, no solo nos permitió construir conocimientos sobrelas prácticas de enseñanza de las ciencias desarrolladasen escuelas primarias durante las primeras semanasde la cuarentena, sino que, además, generó un ámbitodemocrático de participación en comunidades virtuales,en el que el intercambio de saberes, materiales y experiencias diversas nos enriqueció profesional y humanamente. El siguiente texto concreta nuestro esfuerzo porsistematizar la experiencia grupal.
Construcción curricular en los nuevos espacios del diseño secundario. El Holocausto como propuesta de investigación en el Seminario de Ciencias Sociales
Authors: RAYNOLDI GUSTAVO DANIEL
Published: December 2020

En este artículo analizamos algunos aspectosdel nuevo espacio articulado para el nivel secundario:El Seminario de Ciencias Sociales. Su potencial innovador, y algunas tensiones detectadas entre el diseñocurricular y su implementación, son abordados desdeuna experiencia con alumnos del segundo año de laEscuela Juan Marcos de la ciudad de Santa Fe; quienestrabajaron sobre estudios de caso vinculados a la Shoá,el proceso de persecución y exterminio del pueblo judíoeuropeo ejecutado por el régimen nacional socialista delTercer Reich alemán, antes y durante la Segunda GuerraMundial. El diseño curricular del Ministerio de Educación de la Provincia de Santa Fe respecto al Seminario,el encuadre resolutorio que indica a nuestra jurisdiccióneducativa la incorporación de temáticas vinculada alHolocausto, y el Trayecto de Formación Docente sobre laShoá de escala provincial, fueron tres factores que contribuyeron a fundamentar la elección de esta propuestade enseñanza. La experiencia produjo movilizacionesen varios sentidos, que intentamos relacionar con elespacio todavía en construcción del Seminario, con laexpectativa de realizar aportes en nuestra formación ypráctica docente.
Palabra, silencio e igualdad de las inteligencias. Pensar la praxis docente desde un realismo-pragmático salvaje
Authors: GARCÍA JUAN DIEGO
Published: December 2020

En el presente ensayo proponemos detenernos en torno a un problema recurrente en la praxisdocente: la falta de circulación de la palabra en el aula,muchas veces acompañada del desinterés y la apatía delos estudiantes en relación con la propuesta didáctica.Para pensarlo proponemos partir de un relato de experiencia propio, donde este problema se hace presente,y luego esbozaremos una perspectiva de análisis de lapraxis docente, que denominaremos «realismo-pragmático salvaje». La misma nos va a permitir pensar einterrogar el relato de experiencia de un modo singular.Por último, pondremos en relación esta perspectiva conalgunas categorías de El maestro ignorante de JaquesRancière, para intentar problematizar la cuestión delhabla y el silencio en las clases.
Las emociones y los vínculos en la enseñanza y en la formación Entrevista a Diana Mazza
Authors: DI MATTEO MARÍA FLORENCIA
Published: December 2020

Diana Mazza es Doctora enEducación de la Universidadde Buenos Aires y Licenciadaen Ciencias de la Educaciónpor la Universidad de BuenosAires. Profesora Titular regularde la cátedra de Didáctica IIde la carrera de Ciencias dela Educación de la Facultadde Filosofía y Letras de laUniversidad de BuenosAires. Investigadora delInstituto de Investigacionesen Ciencias de la Educaciónde la Facultad de Filosofíay Letras de la Universidadde Buenos Aires en temasvinculados a la formación ya la docencia universitariadesde una perspectiva clínica ygrupal. Docente de posgradoen diversas universidadesnacionales. Fue Vicedirectoradel Programa UBA XXI,de la Secretaría de AsuntosAcadémicos de la Universidadde Buenos Aires. Consultorade diversas institucioneseducativas y organizacionesempresariales en el ámbitode la formación para eltrabajo. Autora de diversaspublicaciones en revistasespecializadas en educación yde libros, entre ellos La tareaen la universidad, editado porEudeba en el año 2013
Models of group poisson flows in telecommunica-tion traffic control
Authors: Likhttsinder Boris Y. , Bakai Yulia O.
Published: December 2020

The lack of effectiveness of the use of models of self-similar processes to the analysis of queues telecommunications systems is presented. The evolution of the flow models managed by Markovs chain is considered. The specifics of the use of Markovs flows as models of telecommunications traffic systems are considered. Models of single-channel queueing systems with input flows that have an arbitrary correlation are presented. Generalizations of the Khinchin-Pollaczek formula are given for these systems. The perspective of the application of interval methods developed by the author for queue analysis in queueing systems with correlated input flows is shown. It is suggested to use the group Poisson extraordinary flow as a model of telecommunication traffic. Interval characteristics of the given flows are reviewed and the prospects of their application are shown. The issues of multiplexing these flows during processing in queueing systems are considered. It is demonstrated that the resulting flow is also a group Poisson flow when summing up several group Poisson flows. The conclusions are confirmed by the simulation modeling results. The examples show the validity of such models to the characteristics of real video traffic flows.
Experimental study of brushless generator with integrated exciter
Authors: Zubkov Yuri V. , Kaurov Sergey Y. , Vereshagin Vladislav E.
Published: December 2020

The paper studies an integrated starter-generator based on a synchronous machine with PM excitation (ISG), used to start an internal combustion engine (ICE) of an autonomous energy facility or vehicle and supply electric energy to its consumers. The purpose of the work is to obtain a mathematical model of the starting mode in the form of a system of differential equations, its virtualization by means of the Matlab Simulink package and a diesel engine starting simulation using ISG with the study of the starting process dynamic characteristics. It is also required to carry out experimental verification of theoretical results through field tests of a prototype starter-generator to confirm the mathematical model adequacy. Difficulties in the analysis and synthesis of ISG are due to the complexity of electromechanical energy conversion processes in it and the trapezoidal nature of the magnetic field spatial distribution in the gap, which was established when solving the magnetostatic problem by the finite element method. These features make it difficult to use traditional research methods. The mathematical model of the operation starting mode, obtained under a number of assumptions that do not affect the nature of electromechanical processes, makes it possible to investigate the ICG static and dynamic characteristics during the electric start of the internal combustion engine. The ISG start-up process simulation was carried out on the basis of equations describing the starter operation using control systems both without starting current limitation and with limitation and providing a sufficient starting torque. Modeling made it possible to determine the start duration and the change of the electromagnetic torque, inverter and winding currents. A prototype ISG was designed and manufactured. Full-scale tests of the diesel engine electric start system were carried out. The results obtained confirmed the adequacy of the developed mathematical model and the possibility of its use in the study of the ISG other specific operating modes.
Optimal inductor design for surface hardening under conditions of interval uncertaity of process parameters
Authors: Popov Anton V.
Published: December 2020

The paper is devoted to the optimal inductor design for surface hardening of steel cylindrical billets. The heating stage of surface induction hardening is considered as an object with distributed parameters, which unknowns are design characteristics of the induction installation. In real industrial conditions the main technological parameters are often defined by the intervals of their possible values. That is why, in the paper the optimal design problem under the conditions of interval uncertainty of initial billets temperature and thermal exchange coefficient is formulated. Solution of the formulated problem is carried out by alternance method of parametric optimization based on numerical model developed in Altair FLUX software.
Bacterial Profile and Antimicrobial Susceptibility of Isolates Recovered from Lower Respiratory Tract Infection for Patients in Rizgary Hospital, Erbil
Authors: Chawsheen Mahmoud A. , Al-Naqshbandi Ahmed A. , Abdulqader Haval H.
Published: December 2020

Recognition of etiologies of lower respiratory tract infection (LRTI) may help in delivering effective treatment options and circumvent emergence of antibiotic resistance. This study was carried out to uncover bacterial profile and antibiotic sensitivity patterns among 310 LRTI patients attended Rizagary Hospital between January 2014 to December 2016. Standard laboratory techniques were applied in collecting, processing, and culturing sputum and bronchial wash specimens. VITEK® 2 compact systems were used to identify bacteria and their antibiotic sensitivity patterns. Results showed that Streptococcus parasanguinis and Acinetobacter baumannii were the most abundant gram-positive and gram-negative bacteria (GPB & GNB), respectively, isolated from sputum specimens. From bronchial wash specimens, only GNB were detected and Serratia marcescens was the most abundant one. Antibiotic sensitivity tests revealed that Streptococcus parasanguinis was the most resistant GPB and Acinetobacter baumannii was the most resistant GNB. Sputum recovered GPB were highly resistant to Ampicillin, Erythromycin, Levofloxacin, Trimethoprim/Sulfamethoxazole, and Tetracycline. Bronchial wash recovered GNB were highly resistant to Ampicillin, Minocycline, Pefloxacin, Piperacillin, and Ticarcillin. In conclusion, LRTIs are mainly associated with GNB rather than GPB. The recovered Streptococcus parasanguinis and Acinetobacter baumannii were found to be multidrug-resistant pathogens. Ampicillin was ineffective against any of recovered pathogenic bacteria.
Bitter Years
Authors: Abozaid Ahmed M.
Published: December 2020

Since the outbreak of the so-called Arab Spring in 2011, the regional system in the Middle East, as well as in the sub-regional system of the Arabian Gulf, has been in flux. Under these new circumstances, the order of the status quo has started to unravel, and a new order is being imposed, accompanied by new regional dynamics and security arrangements. Given their smallness, possession of significant resources, and geostrategic location, most of the members of the Gulf Cooperation Council (GCC) were always vulnerable, because of either the disparity of their capabilities compared with stronger, larger, and aggressive neighbors or the demographic deficiency and general regional imbalance of power. Traditionally, and to preserve their security and stability, these states seek protection from external powers. This article investigates how small, rich states, such as theGCCcountries interact, through the lens of structural realism.
Contextualizing the Palestinian Refugee Camps in the Gaza Strip
Authors: Saleh Shadi
Published: December 2020

Refugee camp spaces are widely analyzed against their host territories. They are constantly associated with isolation and time–space suspension. However, empirical studies show that camps are not simply islands unto themselves. They can have varying levels of interactions with their surroundings. This paper is concerned with contextualizing the Palestinian refugee camps in the Gaza Strip by examining four inseparable dimensions: spatial, socioeconomic, political and time. It unfolds the historical and contemporary interplay between camp and non-camp areas and shows the similarities and distinctions between them. The findings are based on the analysis and fieldwork of Jabalya refugee camp, the largest in the Gaza Strip. Ethnographic research tools are used in addition to text and historical aerial photo analysis. The paper concludes that in a context such as the Gaza Strip in which the majority of the population are refugees, there is a great deal of connectivity between camps and non-camp areas. The camps are far from being described as enclaves, bare lives, or state of exception. The distinctions between them and their surroundings are very subtle. To a large extent, the camps in the Gaza Strip represent a special case of connectivity to a level that has normalized the territory to become a large enclaved refugee space.
The Sustainability Turn in UAE–Japan Relations
Authors: Heng Yee-Kuang
Published: December 2020

Relations between the United Arab Emirates (UAE) and Japan since the 1970s have revolved around oil diplomacy. As the UAE diversifies its economy and embraces sustainability, this paper explores how the bilateral relationship has undergone a sustainability turn. It does so by assessing the logic of sustainability and the mutual interests for both parties. It is argued that the sustainability turn reflects what the UAE needs in terms of renewable technologies and skills, coupled with what Japan can provide in return for favorable oil concessions and new markets. Cases of the Japanese government mobilizing various resources and actors to address the UAE’s sustainability needs are examined to gauge how sustainability has been embedded into the bilateral relationship. The sustainability turn provides not just a fresh analytical lens but also it generates insights into policy and a new assemblage of practices and stakeholders that have emerged as part of this increasingly multilayered relationship.
Way Out Music for Way Out Kids
Authors: Laudadio Nicholas , Sweeney Meghan
Published: December 2020

This article explores the 1960s children’s recordings of Canadian electronic music pioneer Bruce Haack and his collaborator, the American dancer and educator Esther Nelson. Their musical partnership existed at the intersection of music, performance, and technology at a time when all three were changing rapidly. The unpredictable and playful recordings that resulted relied upon DIY electronic equipment to create an unusual range of styles and sounds, from low-fi electronic collage to traditional folk music against a mechanical backbeat; they also, crucially, relied on the input of children. By examining the resulting musical experiments within the cultural and technological context of electronic music from the early 1960s to today, we hope to emphasize that, far from being diminished versions of electronic music, children’s electronic music articulates some of the genre’s most intriguing and lasting concerns. Indeed, the innovations in musical technology and technique deployed in these recordings forecasted changes that would come in electronic music decades later.
Must Be Love On The Brain?
Authors: James Robin
Published: December 2020

As #MeToo activism has revealed cascades of famous and influential men to be serial sexual harassers and rapists, the question of what to do about aesthetically pleasing art made by morally and politically disgusting men has received renewed interest and urgency. I identify two different types of feminist responses to this question. The first kind of response modifies post-feminist and post-race approaches to diversity as a kind of beauty: replacing beauty with disgust, these approaches treat sexism and misogyny as individual-level flaws that can be eliminated through appropriate aesthetic judgments. The second kind of response begins from the premise that centuries of white supremacist capitalist cisheteropatriarchy have shaped our aesthetic principles and conventions such that sexism and misogyny are systemic problems baked into all works of art. I examine how Angela Davis’s revision of Marcuse’s concept of the aesthetic dimension, Katherine McKittrick’s and Alexander Weheliye’s concept of “emulation,” and Rihanna’s vocal performance choices on her 2016 single “Love On The Brain” are all instances of this latter type of response.
Dünnwandige Keramik, Keramik Mit Marmorierter Verzierung Und Gestempelte Keramik in Lágymányos
Authors: Nagy Alexandra
Published: December 2020

The vessel types of the Lágymányos potter’s workshop highlighted in this present paper shed new light on our knowledge of the Roman Age pottery production of the Aquincum district. Thin-walled ceramics draw attention to the significance of South-Pannonian import and the production of its imitations. Dating and design of stamped ceramics, the operation and hundreds of linked motifs of Resatus represent a significant advance. The local variant of marbled ceramics also belongs to the new ceramic types of the period, which, besides vessels of Celtic tradition, became an important product of the workshop.
Juglet Pendants from Pannonia
Authors: Dévai Kata
Published: December 2020

Most juglet pendants are of 4th century from Pannonia, the glass is frequently dark, appearing black. Although juglet pendants have a greater concentration in the eastern Mediterranean, they are also widely attested in the empire’s western half. The following paper1 presents nine specimens from Hungary, eight from Pannonia Province. Three exemplars were parts of grave inventories, whose other items are also known (Bogád, Csongrád and Ságvár). All three burials can be securely dated to the fourth century. Despite the attractiveness of M. Stern’s suggestion, there is no good reason to associate the Pannonian juglet pendants recovered from mortuary contexts with Christianity. The pieces from Pannonia would rather suggest that juglet pendants cannot be associated with Christian beliefs because the other grave goods in the burials from which they were recovered belie this association.
Emperor Avitus in Pannonia?
Authors: Kovács Péter
Published: December 2020

In his paper the author examines the sources of the supposed Western Roman military expedition of Emperor Avitus in Pannonia in 455 that was thought to be the last Roman military action in the territory of the former Roman province. Analizing the sources, he comes to the conclusion that during his short reign, Avitus had no time to visit the province and his route (iter) mentioned by Sidonius Apollinaris must be identified with his journey from Arelate to Rome. The Roman military action in Pannonia can probably be identified with a short demonstrative campaign in the SW region of the dioecesis (i.e. Savia) or with a legation of the Pannonian Barbarians to the emperor in Northern Italy.
Using text analysis for evaluating the behaviour of rates of return from the WIG20 index
Authors: Walentek Dorota
Published: December 2020

Telework, also known as remote work, is now an increasingly popular work system in Poland and around the world. However, the reasons for undertaking remote work by individual teleworkers may be different. The article contains a literature review in terms of both the explication of the concept of teleworking and the motives for undertaking it. The results of the author’s study were also presented, the aim of which was to identify the most important factors influencing the interest in teleworking among students. It was shown that the main motivating factors to work remotely are flexible working hours, the ability to work anywhere in the world and independent work organization. The study was a pilot study carried out just before the COVID-19 pandemic, which forced the introduction of remote work in many organizations that had not used teleworking so far. The intention of the author is to conduct a similar study every one to two years in order to compare the main motives for undertaking remote work before and during the pandemic, or just after its completion
Аналіз комплексної моделі криптосистеми для захисту конфіденційних даних
Authors: Борцова Ю.В. , Плотніков В.М.
Published: December 2020

Для захисту конфіденційних даних від комп'ютерних злочинів  користувач має подбати про безпеку своєї інформації власноруч, використовуючи існуючі сучасні програмні засоби. Одним з таких засобів є реалізація шифрування повідомлень за допомогою прикріплення цифрового підпису до даних. Для роботи криптосистем шифрування з відкритим ключем необхідно три алгоритми: алгоритм шифрування, алгоритм розшифрування та алгоритм генерації ключів.  Одним з перспективних шляхів розвитку шифрування з відкритими ключами є використання моделі піднесення до великої степені дискретних логарифмів для генерування ключів – алгоритм Діффі-Хеллмана. Аналізується спектр можливих кібератак, специфіка їх реалізації, та напрямки дії, надаються теоретичні аспекти протоколу обміну ключами Діффі-Хеллмана, проводиться їх реалізація, тестування протоколу і порівняльний аналіз реалізацій програмного продукту.
Total electrolyte balance for laying hens
Authors: Silva Vitor Colossal da , Araújo Wagner Azis Garcia de , Valentim Jean Kaique , Brito Hébert Fernandes de , Messias Hérica da Silva , Siqueira Bruna Pereira , Silva Bruno Alexander Nunes , Lacerda Dielly Inêz Oliveira
Published: December 2020

ABSTRACT: This study was done to determine the best value of the total electrolyte balance (BET) concerning the variables of performance and egg quality of the laying hens. We investigated 240 Hy-Line Brown laying hens, of 30 to 46 weeks of age, adopting the completely randomized experimental design, which included five treatments (1000, 1250, 1500, 1750 and 2000 μeq / kg), 8 repetitions and 6 birds per unit. The performance and quality of the birds’ eggs were evaluated in the different treatments. The results were subjected to the analysis of variance and, wherever significant effect was noted, the regression equations were estimated, taking into account the electrolyte balance (μeq / kg) as a concomitant variable, applying the SAS statistical program (2001). The consumption, production, and feed conversion variables by dozen eggs, final bird weight, egg density, yolk color, Haugh Unit, albumen weight, shell weight, and egg weight, were found to be unaffected by the experimental BET values. The values of the feed conversion per egg mass, yolk weight and uniformity were affected by the different BETs. The electrolyte balance values showing minimum feed conversion, higher yolk weight, and better uniformity were, respectively, BET = 1400, 1330, and 1250 in μeq / kg of loads at the different temperatures. From the regression equations, the value indicated was BET=1390 for the 30- to 46-week-old laying hens. The electrolyte balance of the diet was found to affect the laying hens in terms of performance and egg quality.
Management of white mold of soybean using winter cereal straw
Authors: Feller Leandro André , Corrêa Jessica Vanessa Wosniak , Leite Carla Daiane , Santos Leandro Alvarenga , Faria Cacilda Márcia Duarte Rios , Mendes Marcelo Cruz
Published: December 2020

ABSTRACT: The management of white mold (Sclerotinia sclerotiorum(Lib.) De Bary) has been one of the main production limitations faced by soybean (Glycine max L.) producers. Considering the complex management of this disease and resistance structure of the pathogen, the present study was conducted in the municipalities of Guarapuava and Palmas in Paraná with the objective of managing the white mold of soybean using straws of winter cereals, such as oat, rye, and triticale. Initially, the three winter cereals were cultivated simultaneously in both the study areas. Straw production, plant height, and shoot fresh and dry weight were evaluated. Subsequently, BMX Apollo soybean was cultivated on cereal straws, and the incidence and severity of white mold were evaluated. In the in vitro experiment, 20 sclerotia covered by a layer of cereal (oat, rye, and triticale) straws were added and carpogenic germination was observed only in the control treatment after 98 days. Regardless of the study site, rye presented greater height and fresh weight than the remaining two cereals. Soybean cultivation on winter cereal straw reduced the incidence and severity of white mold. Cultivation on rye straw reduced mold incidence by 77.7% and 76.6% in Palmas and Guarapuava, respectively.
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
Authors: González Luis Bustos , Simirgiotis Mario Juan , Parra Claudio , Alfaro-Lira Susana , Soto Emilio , Echiburú-Chau Carlos
Published: December 2020

ABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.
Selenium supplementation prevents DNA damage in ram spermatozoa
Authors: Moya Carla Fredrichsen , Piagentini Marcelo , Silva Danilo da Cunha , Fernandes Fábio Henrique , Salvadori Daisy Maria Fávero , Oba Eunice
Published: December 2020

ABSTRACT: In the present study, we aimed to evaluate the effects of different concentrations of selenium (Se) ovine nutritional supplementation on spermatozoa DNA integrity. Thirty male ovines (age: 10 months) were used. They were fed with hay and ram food in an intensive system, which was divided into stalls (5 m long and 3 m wide) with feeding troughs, and had ad libitum access to food and water. Ovines in group 1 (G1, the negative control) received mineral salt supplementation without Se; ovines in G2 received the same mineral salt mixed with 5 mg Se (as sodium selenite)/kg mineral supplement;ovines in G3 received 10 mg Se/kg mineral supplement; ovines in G4 received 15 mg Se/kg mineral supplement; and ovines in G5 received 20 mg Se/kg mineral supplement. Ovines in all groups remained untreated for 14 days, followed by a treatment period of 56 days. Semen samples were obtained by electroejaculation. The DNA damage in semen samples was evaluated using the comet assay. The experimental design was implemented using a 5 × 5 Latin Square, i.e., five treatments and five experimental periods. The mean differences were compared using Tukey’s test at a significance level of 5%. The control group (G1) showed a high percentage of DNA damage compared to the Se-treated groups (G2-G5). Therefore, Se supplementation could decrease the basal level of DNA damage in sperm cells, suggesting that Se might exert protective effects on sperm DNA.
Nutraceutical fruit characterization, nutritional aspects and sensory analysis of dovyalis jams
Authors: Rotili Maria Cristina Copello , Villa Fabíola , Silva Daniel Fernandes da , Rosanelli Solivan , Braga Gilberto Costa , Eberling Tatiane
Published: December 2020

ABSTRACT: The objective of this study is to evaluate the composition, nutritional aspects and sensory analysis of the dovyalis jam. Dovyalis fruits were harvested from 4-year-old plants in the orchard of the Unioeste Experimental Farm. They were collected in the morning in polyethylene boxes, when they were ripe and with a purple coloration from the epicarp, being immediately transported to the Laboratory to prepare the jams. After fruits arrival, they were selected by size, color and weight and then sanitized in running water and the cups of the fruits were removed. The sensory evaluations of the jam samples were performed in a randomized fashion, with 30 volunteer tasters. The tasters were previously advised to evaluate the acceptance of the jams and their purchase intentions. Fruits in natura and dovyalis jam are sources of vitamin C. Dovyalis fruits can be used in the processing, due to its acidity. The jam prepared with dovyalis fruits without epicarp and endocarp, and less sugar, was more appreciated by the tasters.
Correlation of serum acute-phase proteins with bone repair in rabbits (Oryctolagus cuniculus) submitted to partial radio ostectomy
Authors: Calciolari Karina , Dissenha Adrielly , Galíndez Júlian Andrés Sanjuán , Lucena Dayvid Vianêis Farias de , Rossignoli Pedro Paulo , Rocha Fabiana Del Lama , Minto Bruno Watanabe
Published: December 2020

ABSTRACT: Bone trauma triggers an acute inflammatory response, which can alter the serum concentration of acute-phase proteins (PFA). We aimed to evaluate the effectiveness of PFA measurement as a laboratory biomarker for inflammation related to bone regeneration. A partial ostectomy of the right radius was performed on 22 young male rabbits. The complete blood count, albumin, ceruloplasmin, haptoglobin, C-reactive protein, and transferrin levels were recorded and correlated with the radiographic evolution of bone healing. Statistically the best correlations with the inflammatory process and radiological findings were reported with haptoglobin and transferrin compared to the other measured PFAs. Haptoglobin and transferrin showed a maximum peak 24 and 36 hours after surgery, respectively. Transferrin displayed signs of decrease in the first 6 hours after surgery, in advance of the leukocyte response. The measurement of acute-phase proteins proved to be viable, considering the conditions in which the present study was carried out. Among all variables studied, haptoglobin and transferrin showed best correlation with the inflammatory process of bone healing. Additional studies are needed to determine the sensitivity of acute-phase proteins as predictors of complications in the treatment of fractures.
HIIT, RESISTANCE TRAINING, AND RISK FACTORS IN ADOLESCENTS: A SYSTEMATIC REVIEW
Authors: Faria Waynne Ferreira de , Mendonça Filipe Rodrigues , Elias Rui Gonçalves Marques , Oliveira Raphael Gonçalves de , Stabelini Neto Antonio
Published: December 2020

ABSTRACT It has been shown that combined physical exercise is an efficient non-pharmacological approach in the context of public health, since it has demonstrated satisfactory results in the prevention, treatment and control of various morbidities. Therefore, it is essential to systematize current knowledge to enable professionals involved in the prescription of physical exercise to do so based on evidence. Thus, the objective of this study was to perform a systematic review of randomized clinical trials to verify changes in cardiometabolic risk factors induced by high-intensity interval training (HIIT) and resistance training (RT) in adolescents. The systematic search was performed in the following databases: Pubmed, ScienceDirect, Cochrane, LILACS and Scielo. Initially 933 studies were identified, then two researchers eliminated duplications and manuscripts that did not meet the eligibility criteria. Thus, two articles were included that met these criteria: a randomized clinical trial conducted with adolescents (10 to 19 years) of both sexes, an intervention lasting for at least four weeks, which prescribed HIIT and RT in the same session or not, and evaluation of at least one cardiometabolic risk factor. The results demonstrated that eight to 12 weeks of HIIT and RT without nutritional intervention were effective in significantly reducing waist circumference and body fat percentage. However, data pertinent to the efficacy of this combination on risk of developing type 2 diabetes mellitus and arterial hypertension are controversial. In view of the above, it is ascertained from the included studies that the combination of HIIT and RT has the potential to reduce cardiometabolic risk factors in adolescents; therefore, further studies should be conducted to determine the effectiveness of this prescription of physical exercise. Level of Evidence II; Systematic review of Level II or Level I Studies with discrepant results.
BIOMECHANICS OF SHOD AND BAREFOOT RUNNING: A LITERATURE REVIEW
Authors: Jahn Vitória da Silveira , Correia Clara Knierim , Dell’Antonio Elisa , Mochizuki Luis , Ruschel Caroline
Published: December 2020

ABSTRACT This study aims to analyze and summarize the biomechanical (kinematics, kinetics and neuromuscular) differences between shod and barefoot running, through a literature review. Searches were conducted for complete articles published between 2013 and November 2018 in the Web of Science, PubMed, Scopus and SPORTdiscus databases. The search terms used were Biomechanics, Kinetics, Kinematics, Electromyography, “Surface Electromyography”; and Unshod, Barefoot, Barefeet and Running. The search resulted in 687 articles; after excluding duplicates and selecting by title, abstract and full text, 40 articles were included in the review. The results show that there are important differences in the biomechanics of running when shod or barefoot. In general, studies indicate that in barefoot running: a) individuals present forefoot or midfoot foot strike patterns, while in shod running the typical pattern is the rearfoot strike; (b) greater cadence and shorter stride length are observed; and (c) there is greater knee flexion, lower peak vertical ground reaction force and greater activation of the medial gastrocnemius. In addition, barefoot runners contact the ground with greater plantar flexion, possibly as a strategy to reduce impact when stepping without footwear. These differences, as well as runners’ individual characteristics, should be considered in the prescription of the barefoot running, in order to minimize injuries resulting from the practice. Level of Evidence II; Review.
EFFECT OF EXERCISE WITH CONTINUOUS AND INTERMITTENT BLOOD FLOW RESTRICTION ON HEMODYNAMICS
Authors: Silva Hidayane Gonçalves da , Rodrigues Neto Gabriel , Vasconcelos Wanessa Kelly Vieira , Pereira-Neto Elísio Alves , Silva Julio Cesar Gomes da , Bittar Simoni Teixeira , Cirilo-Sousa Maria Socorro
Published: December 2020

ABSTRACT Introduction: Strength training with blood flow restriction (BFR) involves the use of low loads (20-30% of 1RM) with restriction of blood flow to promote gains in physical fitness. The restriction can be applied continuously or intermittently; however, it is unclear how it affects the hemodynamics of hypertensive women. Objective: To analyze the acute effect of resistance exercise (RE) on the upper and lower limbs with continuous and intermittent blood flow restriction (BFR) on the hemodynamic variables of women with hypertension. Methods: Thirteen women with controlled hypertension (40 to 65 years) underwent eight experimental protocols, with a randomized, counter balanced, crossover design; four exercise sessions for the right upper limb (elbow flexion) and four for the right lower limb (knee extension). The systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and heart rate (HR) were measured before, during, immediately after and 15, 30, 45 and 60 minutes after the exercises. Results: There were no significant interactions between the protocols vs. segments vs. time, protocols vs. segments, protocols vs. time, segments vs. time, protocol, segment and time, on the variables SAP, DAP, and HR during and after the RE (p>0.05). Although all these protocols had significantly elevated SAP, DAP and HR, the values remained within the normal range. The protocols of this study did not cause hypotensive effect. Conclusion: Low-load RE combined with continuous and intermittent BFR, on the upper and lower limbs, appears to promote similar variations in the hemodynamic variables of women with hypertension. Level of evidence II; Randomized clinical trial.
Avaliação das artérias podais ao eco-Doppler
Authors: Takahashi Luciana Akemi , França Graciliano José , Valle Carlos Eduardo Del , Ferreira Luis Ricardo Coelho
Published: December 2020

Resumo A ultrassonografia vascular com Doppler é um método não invasivo útil no diagnóstico e planejamento terapêutico da doença oclusiva das artérias podais. A artéria pediosa dorsal é a continuação direta da artéria tibial anterior e tem trajeto retilíneo no dorso do pé, dirigindo-se medialmente ao primeiro espaço intermetatarsiano, onde dá origem a seus ramos terminais. A artéria tibial posterior distalmente ao maléolo medial se bifurca e dá origem às artérias plantar lateral e plantar medial. A plantar medial apresenta menor calibre e segue medialmente na planta do pé, enquanto a plantar lateral é mais calibrosa, seguindo um curso lateral na região plantar e formando o arco plantar profundo, o qual se anastomosa com a artéria pediosa dorsal através da artéria plantar profunda. A avaliação das artérias podais pode ser realizada de maneira não invasiva com exame de eco-Doppler, com adequado nível de detalhamento anatômico.