bluuebunny/crossref_metadata_2025 huggingface dataset:
Mapping cohesive device usage to analyse non-native writers’ needs in academic English
Authors: Ashadi Ashadi , Margana Margana , Mukminatun Siti
Published: May 2023

Native or non-native English-speaking academics are compelled to write scientific articles in internationally reputable indexed journals today. With high demand of academic English, more and more articles are rejected by the editorial board for various reasons, mainly in the cohesion and coherence of their writing. This research seeks to map the types and patterns of cohesive device used to support the coherence of scientific articles. Employing a descriptive qualitative approach, this study compared the use of cohesion devices (CD) by both groups’ writing (native non-native) to further bridge the difficulties faced by non-native writers in shaping their academic writing cohesively and coherently. This study may also serve as a needs analysis that allows for the creation of models, materials, and teaching approaches to scientific article writing for learners of English as a foreign language.
Wacana kekuasaan dan politik dalam kumpulan cerita pendek Penembak Misterius dan Saksi Mata karya Seno Gumira Ajidrama
Authors: Indra Andi Batara , Wiyatmi Wiyatmi
Published: May 2023

Penelitian ini untuk mengetahui (1) wujud wacana kekuasaan, (2) praktik wacana kekuasaan, (3) wujud wacana politik, dan (4) praktik wacana politik dalam kumpulan cerita pendek Penembak Misterius dan kumpulan cerita pendek Saksi Mata karya Seno Gumira Ajidarma. Penelitian ini merupakan penelitian kualitatif deskriftif. Objek peneltian adalah kumpulan cerita pendek Penembak Misterius dan kumpulan cerita pendek Saksi Mata karya Seno Gumira Ajidarma. Pengumpulan data menggunakan studi pustaka. Analisis data menggunakan kualitatif deskriftif. Hasil penelitian menunjukkan kumpulan cerita pendek Penembak Misterius dan kumpulan kumpulan cerita pendek Saksi Mata karya ditemukan empat wujud wacana kekuasaan yang berbentuk disiplin atau disciplinary, hukuman atau punisment, kuasa tubuh atau biopower, dan pengetahuan  atau knowledge. Praktik wacana kekuasaan ditemukan empat praktik yang berbentuk pembunuhan, teror, penculikan, dan penyiksaan. Wujud wacana politik dalam kumpulan cerita pendek Penembak Misterius dan kumpulan cerita pendek Saksi Mata karya Seno Gumira Ajidarma ditemukan tiga wujud wacana politik yang berbentuk politik pemerintah atau negara, politik seksual atau gender, dan politik instansi. Praktik wacana politik ditemukan dua jenis praktik yang berbentuk kebijakan dan aturan. Power and politic discourse in Seno Gumira Ajidarma’s short stories entitled Penembak Misterius and Saksi Mata Abstract: The purpose of this study is to understand (1) the existence of discourse of power, (2) the example of power, (3) the existence of political discourse, and (4) the example of political discourse in Seno Gumira Ajidarma’s Short Stories Penembak Misterius and Saksi Mata. The study is qualitative research. The data were obtained by reading intensively, making a systematic list, looking for other references, identifying the existing discourse of power and the example of power, identifying the existing discourse of politics and the example of political case. The analysis of this study used the descriptive qualitative method by classifying, interpreting, analyzing, and concluding the data. The result of this study shows that there are four forms of power: knowledge, discipline, punishment, and biopower in  Seno Gumira Ajidarma’s Short Stories entitled Penembak Misterius and Saksi Mata. Also, there are four examples of political cases such as assassination, terror, kidnapping, and torture. Besides, there are three forms to show the existence of politics such as government politics, gender politics, and office politics and two forms to describe political practice such as policy and regulation.
Developing multimedia for reading instruction
Authors: Pratiwi Erita Budi , Wiedarti Pangesti
Published: May 2023

This research study aimed to (1) develop multimedia for reading instruction for the ninth-grade students at SMP N 1 Kalasan, and (2) find out the quality of multimedia for reading instruction for the ninth-grade students at SMP N 1 Kalasan. This research study applied research and development adapted from Lee Owens (2004). The development of multimedia in this study was conducted in four stages: analysis, design, development, and evaluation and revision. Data were obtained through questionnaires. The collected data were analyzed by means of descriptive statistics. The findings showed that the quality of the developed multimedia for reading instruction for the ninth-grade students at SMP N 1 Kalasan was “good” in terms of instructional and material aspects (with average scores 4.17 and 4.10) respectively, and “excellent” in terms of media aspect (average score 4.23). In terms of those three aspects, the developed multimedia was categorized as “good” with an average score of 4.16.
Developing reading learning materials for 2nd semester students of international relations department
Authors: Azizah Luthviana , Priyana Jaka
Published: May 2023

This research study aimed to develop reading learning materials to facilitate 2nd-semester students of the International Relations Department in learning reading skills through Bahasa Inggris Hubungan Internasional II subject. This research was a research and development study. The development of the learning materials was carried out through several steps, namely needs analysis, syllabus design, product development, product validation, product revision, try-out, and final product development. This research developed four units of reading learning materials. The appropriateness of the learning materials is viewed from four aspects, namely content, activities, language, and graphics. The expert judgements and field-testing data indicate that the learning materials are appropriate as shown by the mean scores of the expert evaluation ranging from 3.0 to 3.72 and students’ agreement ranging from 3.1 to 3.7 on 4 to 1 Likert scale
Developing English learning materials for grade eight students at IOs International Education Yogyakarta
Authors: Sari Ary Diah Puspita , Priyana Joko
Published: May 2023

This research aims to develop English learning materials for grade eight students at IOs International Education. This research adopted the material development procedure proposed by Graves (2000: 105) and Dick, Carey and Carey (2005:1). The data were collected by using observation sheets and questionnaires. The data were quantitative and qualitative data. The quantitative data were analyzed using descriptive statistics, while the qualitative data were analyzed qualitatively. The results of this study are four units of learning materials. Each unit consists of 18 to 20 tasks. Each unit is organized into six components namely introductory page, warm-up, main tasks (spoken cycle and written cycle), summary, evaluation, and glossary. The research results show that the developed course materials of English for grade eight obtained a score of 4.414 (very good). Then, the students’ try-out results obtained 4.47 (very good). These results show that the developed English course materials of English for eighth grade students in IONs International Yogyakarta are appropriate.
Integrating digital tools into ESP teaching: A need analysis of a business English course
Authors: Kholis Adhan , Iryanti Heni Dwi
Published: May 2023

This case study was a preliminary stage of an on-going research and development project on developing a business English textbook integrated with digital tools for students of English Education at Nahdlatul Ulama University of Yogyakarta. It investigated the students’ perceived needs on their business English course. To collect the data, a needs analysis questionnaire was administered to the students using Google form including the students’ necessities, lacks, and wants for a practical business English course design. Both quantitative and qualitative methods were used to analyse the collected data. It defined the context in which the students would use business English in their future profession. Results showed that (1) the students’ English proficiency was still in the middle, (2) The use of English in daily life communication was on occasion, (3) The English skills’ preferences should be learnt in the business context were speaking, writing, listening, and reading, (4) Topics included in the business contexts were interview, curriculum vitae, and presentation in the top three, (5) Digital tools’ preferences to be integrated into learning were Kahoot, Padlet, and VoiceThread in the top three, and (6) Learning methods implemented were group discussion and project-based learning in the top two.
Mood structures and their functions to reveal white’s dominance: A critical discourse analysis in Doris Lessing’s The Grass is Singing
Authors: Nursanti Emi
Published: May 2023

This discourse study aims to analyze the structure and function of the modes in the speech of the characters in The Grass is Singing concerning white domination over black people. This is a qualitative study with a critical discourse analysis approach. The findings conform Fairclough’s theory (1989) that the mood structure, whether declarative, interrogative, or imperative, can show the speaker's dominance and power. In the declarative mode, the speaker or the person giving the information tends to be in a higher position than the interlocutor. In the interrogative and imperative modes, the person who asks for both information and action from the interlocutor is generally more dominant. These findings reveal that white people consider their group to be superior to black people even though within the white group itself a social class division exists where those who are more successful will be more powerful than people who are struggling economically.
Prediction of Outcomes After Heart Transplantation in Pediatric Patients Using National Registry Data: Evaluation of Machine Learning Approaches
Authors: Killian Michael O , Tian Shubo , Xing Aiwen , Hughes Dana , Gupta Dipankar , Wang Xiaoyu , He Zhe
Published: May 2023

Background

The prediction of posttransplant health outcomes for pediatric heart transplantation is critical for risk stratification and high-quality posttransplant care.

Objective

The purpose of this study was to examine the use of machine learning (ML) models to predict rejection and mortality for pediatric heart transplant recipients.

Methods

Various ML models were used to predict rejection and mortality at 1, 3, and 5 years after transplantation in pediatric heart transplant recipients using United Network for Organ Sharing data from 1987 to 2019. The variables used for predicting posttransplant outcomes included donor and recipient as well as medical and social factors. We evaluated 7 ML models—extreme gradient boosting (XGBoost), logistic regression, support vector machine, random forest (RF), stochastic gradient descent, multilayer perceptron, and adaptive boosting (AdaBoost)—as well as a deep learning model with 2 hidden layers with 100 neurons and a rectified linear unit (ReLU) activation function followed by batch normalization for each and a classification head with a softmax activation function. We used 10-fold cross-validation to evaluate model performance. Shapley additive explanations (SHAP) values were calculated to estimate the importance of each variable for prediction.

Results

RF and AdaBoost models were the best-performing algorithms for different prediction windows across outcomes. RF outperformed other ML algorithms in predicting 5 of the 6 outcomes (area under the receiver operating characteristic curve [AUROC] 0.664 and 0.706 for 1-year and 3-year rejection, respectively, and AUROC 0.697, 0.758, and 0.763 for 1-year, 3-year, and 5-year mortality, respectively). AdaBoost achieved the best performance for prediction of 5-year rejection (AUROC 0.705).

Conclusions

This study demonstrates the comparative utility of ML approaches for modeling posttransplant health outcomes using registry data. ML approaches can identify unique risk factors and their complex relationship with outcomes, thereby identifying patients considered to be at risk and informing the transplant community about the potential of these innovative approaches to improve pediatric care after heart transplantation. Future studies are required to translate the information derived from prediction models to optimize counseling, clinical care, and decision-making within pediatric organ transplant centers.
Low Adoption of Video Consultations in Post–COVID-19 General Practice in Northern Europe: Barriers to Use and Potential Action Points
Authors: Assing Hvidt Elisabeth , Atherton Helen , Keuper Jelle , Kristiansen Eli , Lüchau Elle Christine , Lønnebakke Norberg Børge , Steinhäuser Jost , van den Heuvel Johannes , van Tuyl Lilian
Published: May 2023

In the wake of the COVID-19 pandemic, video consultation was introduced in general practice in many countries around the world as a solution to provide remote health care to patients. It was assumed that video consultation would find widespread adoption in post–COVID-19 general practice. However, adoption rates remain low across countries in Northern Europe, suggesting that barriers to its use exist among general practitioners and other practice staff. In this viewpoint, we take a comparative approach, reflecting on similarities and differences in implementation conditions of video consultations in 5 Northern European countries’ general practice settings that might have created barriers to its use within general practice. We convened at a cross-disciplinary seminar in May 2022 with researchers and clinicians from 5 Northern European countries with expertise in digital care in general practice, and this viewpoint emerged out of dialogues from that seminar. We have reflected on barriers across general practice settings in our countries, such as lacking technological and financial support for general practitioners, that we feel are critical for adoption of video consultation in the coming years. Furthermore, there is a need to further investigate the contribution of cultural elements, such as professional norms and values, to adoption. This viewpoint may inform policy work to ensure that a sustainable level of video consultation use can be reached in the future, one that reflects the reality of general practice settings rather than policy optimism.
Parents’ Perceptions of the Factors Influencing the Uptake of Remote Pediatric Hearing Aid Support: Development of a Conceptual Framework
Authors: Kuschke Silva , Moodie Sheila , Kirubalingam Keshinisuthan , O'Hagan Robin , Glista Danielle
Published: May 2023

Background

To achieve effective integration of virtual care into family-centered audiology practices, participatory research methods, including parents as vital participants in the delivery of pediatric audiology care, should be considered. A better understanding of the barriers and facilitators influencing the adoption of virtual care for families is warranted.

Objective

This study aimed to develop a conceptual framework of the factors perceived to influence the adoption of remote pediatric hearing aid support among the parents of children with hearing loss.

Methods

A total of 12 parents of children who wear hearing aids, between the ages of 0-17 years, were recruited to participate in group or individual interviews as part of the 6-step participatory-based concept mapping (CM) process. Data collection was specific to parents in a Canadian context. Analyses included multidimensional scaling and hierarchical cluster analysis.

Results

The CM process resulted in 6 main themes, displayed in a cluster map according to their order of importance. These themes include access to timely, consistent care; technology considerations; convenience; child engagement; cost; and partnership considerations. Key underlying statements and subthemes are highlighted per theme.

Conclusions

Findings from this study demonstrate the use of CM in participatory research with parents and as part of a family-centered care model. Future research should aim to investigate the factors that influence the uptake of remote hearing aid support in different contexts, for example, in low- to middle-income countries versus those in high-income countries.
Survice-BERT: A BERT (Bidirectional Encoder Representations from Transformers) Model for Biomedical Named Entity Recognition in Disease Surveillance Reports (Preprint)
Authors: Cheon Jr Saeyeon , Ahn Sr Insung
Published: May 2023

BACKGROUND

Since the emergence of the novel coronavirus disease (COVID-19), it is becoming increasingly important to predict infectious diseases to prevent their spread. Researchers have conducted studies on forecasting infectious diseases to control post pandemics. However, the lack of infectious disease surveillance datasets and the difficulty of monitoring outbreaks obstruct the research development.

OBJECTIVE

This study aims to create language model which can extract disease outbreak information from periodic reports of infectious diseases. We present a developing approach about our NER (Named Entity Recognition) datasets based on infectious disease surveillance reports and our Survice-BERT (Bidirectional Encoder Representations from Transformers) model fine-tuned by our datasets for immediate pandemics response.

METHODS

We built our datasets by crawling and pre-processing infectious disease surveillance reports. The structure of datasets consist of 7000 sentences and eight NER tags (Year, Month, Week, Day, Location, Disease, Case, and Death of disease). We fine-tuned two BERT model among biomedical domain-specific pre-trained models. Totally, we experimented 40 times by differing batch sizes and learning rates. We evaluated F1-scores of models by NER tags and compared each classifier performance.

RESULTS

The proposed model achieved a high F1 average of 0.99. We demonstrated this model extracts data with high performance and remarkably improve research forecasting of infectious diseases outbreaks.

CONCLUSIONS

It will help save lives from infectious diseases. The Survice-BERT model will be freely available on our GitHub.
La domesticación de las almas: El nahualismo y sus variaciones / The domestication of souls: Nahualism and its variations
Authors: Millán Saúl
Published: May 2023

En Mesoamérica, donde la domesticación de animales se desarrolla tan solo al inicio del periodo colonial, los vínculos entre los hombres y los espíritus han estado sujetos a una trayectoria divergente que supone concepciones opuestas sobre el mundo animal. Aunque estas diferencias son relativas, permiten vislumbrar dos formas alternativas de concebir el nahualismo, cuyas funciones suelen distribuirse entre la depredación de las almas y la protección de los hombres. A través del novedoso mundo de la ganadería, el artículo examina estas variaciones entre diversos pueblos mesoamericanos, a fin de comparar sus diferencias y sus similitudes.Abstract: In Middleamerica, where the domestication of animals takes place only at the beginning of the colonial period, the links between the men and the spirits have been subject to a different process involving opposed conceptions about the animal world. Although these differences are relative, they allow to see two alternative ways of conceiving the nahualismo, whose functions are usually distributed between the depredation of the souls and the protection of men. Through the innovative world of livestock, the article examines these variations between different Mesoamerican peoples, in order to compare their differences and their similarities.Keywords: nahualismo; shamanism; domestication; livestock; predation.Résumé : En Mésoamérique, où la domestication des animaux a lieu uniquement au début de la période coloniale, les liens entre les hommes et les esprits ont été soumis à un procés divergent qui impliques des conceptions opposées sur le monde animal. Bien que ces différences sont relatifs, nous permettent d’apercevoir deux façons de concevoir le nahualismo, dont les fonctions sont généralement distribuées entre la déprédation des âmes et la protection des hommes. À travers le monde innovateur de l’élevage, l’article examine ces variations entre les différents peuples mésoaméricains, afin de comparer leurs différences et leurs similitudes.Mots-clés : nahualisme ; chamanisme ; domestication ; élevage ; prédation.
L’exvoto ou les métamorphoses du don / El exvoto o las metamorfosis del don
Authors: Lerma Gómez Maria del Carmen
Published: May 2023

Este es un libro centrado en el estudio y la reflexión de las interacciones existentes entre el ser humano y las divinidades, donde la promesa del don se hace presente mediante las manifestaciones físicas de los objetos votivos, entendidos como aquellos que se realizan para ganar el favor de fuerzas superiores. El adjetivo votivo califica a todo lo que es resultado de un voto, ofrenda o dedicación, especialmente de carácter religioso (no limitado al contexto cristiano).
Case report of neurosyphilis with intrathecal synthesis of oligoclonal antibodies
Authors: Makarov S.O. , Kalbus O.I. , Bukreiva Yu.V. , Pashkovskyi V.I.
Published: May 2023

A clinical case is described which occurred in the practice of the Department of Neurology 1 of the Mechnikov Dnipropetrovsk Regional Clinical Hospital. Using the patient’s case history as an example, some possible difficulties in a differential diagnosis of neurosyphilis and demyelinating diseases are shown, peculiarities of laboratory diagnosis of the former are highlighted and reviewed, and also the diagnostic importance of identification of antibody synthesis type during a cerebrospinal fluid analysis for detecting oligoclonal bands is explained. The article contains a brief overview of the works related to modern views on the place and role of the cerebrospinal fluid analysis for a diagnosis and a differential diagnosis of diseases of the nervous system, for studying the types of antibody synthesis in the blood serum and in the cerebrospinal fluid, as well as to some aspects of diagnosing syphilis.
Вплив куркуміну та кверцетину на патогенез раку молочної залози шляхом зниження регуляції miR-632 та miR-137
Authors: Türköz Uluer Elgin , Yusuf Pekmezci Muhammet , Ensarioğlu Hilal Kabadayi , Kemal Özbilgin Mahmut
Published: May 2023

Актуальність. Куркумін і кверцетин виявилися дуже ефективними проти раку молочної залози. Однак повністю їх протипухлинні механізми невідомі. У цьому дослідженні вивчено вплив куркуміну та кверцетину на ріст лінії клітин раку молочної залози людини MCF-7 та MDA-MB-231 шляхом регуляції miR-632 та miR-137. Матеріали та методи. Клітини MCF-7 і MDA-MB-231 обробляли куркуміном і кверцетином у різних розведеннях протягом 24 і 48 годин. Життєздатність клітин оцінювали за допомогою MTT-аналізу. Кількісна полімеразна ланцюгова реакція в реальному часі була використана для виявлення експресії miR-632 і miR-137 у клітинах MCF-7 і MDA-MB-231, оброблених куркуміном і кверцетином. Результати. Наші результати показали, що 50-мкМ розведення куркуміну та кверцетину протягом 24 годин було більш ефективним щодо пригнічення росту клітин MCF-7 та MDA-MB-231. У групах, які отримували куркумін і кверцетин, експресія miR-137 і miR-632 була знижена порівняно з контрольними групами. Експресія miR-137 у клітинній лінії MCF-7 була нижчою, ніж у клітинній лінії MDA-MB-231. Висновки. Використання куркуміну і кверцетину зменшувало ріст лінії клітин раку молочної залози людини MCF-7 і MDA-MB-231 шляхом зниження регуляції miR-137 і miR-632. Цей висновок показав, що куркумін і кверцетин можуть бути використані як терапевтичний засіб, а також що miR-137 і miR-632 застосовуються для діагностики, оцінки ефективності лікування та прогнозу при раку молочної залози.
РІ3К-шлях клітинної регуляції при раку молочної залози: патофізіологія та значення в лікуванні
Authors: Kovbasiuk A.O. , Lobanova O.Ye. , Zotov O.S.
Published: May 2023

У статті розглянуто доцільність використання алпелісибу при HR+/HER2– раку молочної залози за наявності мутації РІ3КСА на основі даних, наведених у дослідженнях BOLERO-3, SAFIR-2 та SOLAR-1. За результатами проведених клінічних досліджень було виявлено, що додавання до ендокринної терапії алпелісибу при HR+/HER2– РМЗ поліпшує виживаність без прогресування в 1,32 раза, на відміну від монотерапії гормональними препаратами та використання хіміотерапії, та не має сильних токсичних ефектів, які потребують відміни препарату. Окремо увагу слід звертати на пацієнтів із цукровим діабетом, оскільки особлива токсична дія алпелісибу проявляється у підвищенні рівня цукру в крові.
Пухлиноінфільтруючі лімфоцити: нові виклики імунотерапії солідних пухлин
Authors: Nikolaieva O.Yu.
Published: May 2023

Пухлиноінфільтруючі лімфоцити (tumor infiltrative lymphocytes, TIL) — це лімфоцити, що локалізуються у пухлинній тканині. Після ізоляції, скринінгу та ампліфікації in vitro вони вводяться назад в організм пацієнта і мають специфічний знищуючий ефект на пухлини. Оскільки TIL не були генетично модифіковані та походять з організму пацієнтів, побічних реакцій зазвичай виникає відносно мало, що є перевагою лікування за допомогою TIL. Останніми роками терапевтична дія TIL на солідні пухлини почала привертати все більше уваги онкологів. Однак через обмеження імунного мікрооточення та мутації антигенів розвиток TIL-терапії сповільнився. У статті розглядається загальний прогрес дослідження TIL, біологічні характеристики, методи посилення терапевтичного ефекту пухлиноінфільтруючих лімфоцитів, їх роль у різних пухлинах, дані останніх клінічних досліджень та перспективи цього виду терапії.
Сучасні підходи до неад’ювантної терапії аденокарциноми прямої кишки (огляд літератури)
Authors: Hannotska A.Yu.
Published: May 2023

Колоректальний рак є другою за поширеністю локалізацією раку як серед чоловіків, так і серед жінок в Україні. Основним способом рецидиву раку прямої кишки є віддалене метастазування. Крім того, хірургічне лікування часом передбачає постійну колостомію, а також супроводжується певною частотою статевої та сечовидільної дисфункції. Ці фактори спонукають до пошуку кращих стратегій лікування, й однією з них може бути інтенсифікація передопераційної терапії. В огляді наведені результати тотальної неоад’ювантної терапії, яка являє собою поєднання хіміотерапії на основі оксаліплатину з довготривалою хіміопроменевою терапією або короткотривалою променевою терапією. Успіхи передопераційних методів лікування призвели до можливості розгляду неоперативного лікування як одного з варіантів подальшого ведення пацієнтів. У той же час актуальності набуває неоад’ювантна імунотерапія, оскільки таким чином можна досягти сильнішої імунної відповіді. Хоч поки що такий підхід не вважається стандартним, ранні результати низки досліджень у цій сфері є багатообіцяючими.
Reflections on the Cultivation of Applied Talents in the Economics Major under the OBE Concept
Authors: Li Na
Published: May 2023

Under the traditional teaching concept, students are in a passive learning state, accepting knowledge and completing tasks step by step according to the teacher’s requirements. In the process of cultivating talents in economics, there are problems such as “emphasizing theory over practice, emphasizing deduction over analysis, emphasizing assessment over application”. Starting from the OBE concept, this paper takes XX University as an example and proposes optimization and improvement ideas for the talent cultivation in economics, focusing on aspects such as setting talent cultivation objectives, investigating social demands, emphasizing ability cultivation, clarifying the roles of teachers and students, designing teaching methods, and evaluating learning outcomes.
Towards Recovery in Schizophrenia
Authors: - Anon
Published: May 2023

None
KETOCONAZOLE LADEN MICROEMULSION BASED GEL FORMULATION AGAINST SKIN FUNGAL INFECTION
Authors: JAIN PAYAL , SONI REENA , PASWAN SURESH K. , SONI PRAKASH K.
Published: May 2023

Objective: The present research was aimed to develop ketoconazole (KT) loaded microemulsion-based gel formulation for effective topical delivery through enhanced drug solubility, improved skin permeation and reduced side effects overcoming drawbacks of conventional dosage forms.
Methods: For the selection of oil, surfactant and co-surfactant mixture (Smix) ratio, the phase titration method was used and pseudo-ternary phase diagrams were prepared. D-optimal mixture design was employed to optimize the microemulsion system taking oil, Smix and water as independent variables and particle size, polydispersity index, zeta potential, % transmittance and cumulative % drug release as response variables. Finally, topical gel formulation of KT-loaded microemulsion was developed and evaluated for physico-chemical properties, rheological properties, in vitro drug release kinetics and ex-vivo drug permeation.
Results: The optimized microemulsion was found to be a transparent formulation with 19.7 nm particle size, 0.268 polydispersity index,-0.2 mV zeta potential, 97.83% transmittance and 85.85% cumulative drug release at 24 h. The developed gel of optimized microemulsion possessed pH 6.20, viscosity 2178 cps, spreadability 18.634 g.cm2/sec, adhesiveness 45.989 N/mm2, and cohesiveness-85.583. The in vitro drug release was found to be 69.08 % (at 24 h), showing sustained release and Higuchi kinetic profile. The developed gel exhibited 1.84-fold higher drug permeation flux as compared to the marketed product.
Conclusion: The developed gel formulation possessed all desired quality attributes and physico-chemical properties. The in vitro and ex-vivo study data proved it’s suitability as a better alternative to conventional products in the effective treatment of fungal skin infections.
Path-connectedness and topological closure of some sets related to the non-compact Stiefel manifold
Authors: El Idrissi Nizar , Kabbaj Samir , Moalige Brahim
Published: May 2023

If H is a Hilbert space, the non-compact Stiefel manifold St(n, H) consists of independent n-tuples in H. In this article, we contribute to the topological study of non-compact Stiefel manifolds, mainly by proving two results on the path-connectedness and topological closure of some sets related to the non-compact Stiefel manifold. In the first part, after introducing and proving an essential lemma, we prove that ∩j∈J (U(j) + St(n, H)) is path-connected by polygonal paths under a condition on the codimension of the span of the components of the translating J-family. Then, in the second part, we show that the topological closure of St(n, H)∩S contains all polynomial paths contained in S and passing through a point in St(n, H). As a consequence, we prove that St(n, H) is relatively dense in a certain class of subsets which we illustrate with many examples from frame theory coming from the study of the solutions of some linear and quadratic equations which are finite-dimensional continuous frames. Since St(n, L2(X, μ; F)) is isometric to, FF(X, μ), n, this article is also a contribution to the theory of finite-dimensional continuous Hilbert space frames.
Stock Market Volatility During Covid
Authors: Dubey Sakshi , Gupta Yash , Jain Mr. Rajiv
Published: May 2023

Abstract: This research paper is a comparatively study on different sector (Pharma, Energy, Oil &Gas and Auto Sector) during 2019 – 2021. If you have to stay in the market then you have to lead the marketin every situation. And thus, from there market stability begins. The Covid-19 pandemic blast as an acetone not in the Indian market but also all over the globe due to which each and every sectorgot affected and also, they are losing their market stability. The Indian stock market has been declined to 30% only the basic reason is Covid. The present study tries to compare the volatility of the companies listed on BSE and NSE during the pre, during and post COVID 19 periods to examine the effect of this pandemic on the economy as a whole.
Improving Digital Forensic Investigations through Automated User Entity Correlation
Authors: Nor Glenn , Abuhmida Dr. Mabrouka , Llewellyn Dr. Eric
Published: May 2023

Abstract: Digital forensic investigation is a time-consuming process, particularly when it comes to manually correlating information between different custodians. Existing methods have been limited in their ability to provide a complete overview of relevant activities and events. In response, this research project has developed a new framework that uses metadata and document entity correlation to identify correlations between custodians. The resulting insights are novel, providing a unique overview of custodian data and a clearer understanding of document content and revisions. Using this framework, digital forensic investigators can extract relevant activity or event-based data, create custom activity or event-based correlation data, and generate event graphs. This approach is an efficient and practical way to generate actionable insights for large-scale investigations.
Use of Automation in Correlation of Metadata Activity in Digital Forensic Investigations
Authors: Nor Glenn , Abuhmida Dr. Mabrouka , Llewellyn Dr. Eric
Published: May 2023

Abstract: Extracting relevant information from large volumes of digital evidence is a significant challenge for digital forensic investigators. Manual analysis is time-consuming and error-prone, and the sheer volume of data can make it difficult to identify correlations and key events. To address this challenge, this research project has developed a new framework that extracts metadata activity timelines and identifies correlations between them. By using this framework, investigators can generate automated correlation data for use in timeline or graph-based visualization. This framework is designed to extract relevant activity or event-based data, design a framework that allows the creation of custom activity or event-based, custodian-specific correlation data, and test the theoretical framework by creating proof-of-concept python implementation code. The resulting insights are novel, enabling investigators to identify crucial correlations and information about document content, order of document revisions, and other relevant metadata activities.
Design and Development of Deep Learning Based Model for Video Analysis
Authors: Umatia Safa , Varshney Tanisha , Yadav Neelam , Kulkarni Ms. Veena
Published: May 2023

Abstract: In order to analyze video streams and extract particular features or patterns, such as object recognition, motion detection, facial recognition, or behavior analysis, video analysis employs computer vision and machine learning techniques. Analyzing video footage to spot suspicious activity or items and locate people or vehicles is part of the process. This approach comprises keeping an eye on and controlling traffic at crossings, on roads, and in highways. It entails reviewing video footage to find traffic jams and overcrowding and to offer prompt alerts or suggestions for crowd management
A Research on YouTube Spam Comments Detection and Deletion
Authors: Bhavsar Darshan
Published: May 2023

Abstract: YouTube is a popular social networking platform that allows users to upload, watch and comment on videos. However, YouTube also attracts spammers who post unwanted or abusive comments on videos, which can affect the quality and credibility of the content and platform. In this paper, we propose a novel approach to detect and delete YouTube spam comments using natural language processing (NLP) algorithms such as Rapid Fuzz and Levenshtein distance. Rapid Fuzz is a Python library that provides fast and accurate fuzzy string matching, while Levenshtein distance is a metric that measures the minimum number of edits required to transform one string into another. We use these algorithms to compare the similarity of comments and identify duplicates, which are a common form of spam. We also use the YouTube API to access and delete a channel’s spam comments. We evaluate our approach on comments of YouTube Video and show that it can effectively detect and delete spam comments with high accuracy and efficiency
Only Classical Parameterised States have Optimal Measurements under Least Squares Loss
Authors: Salmon Wilfred , Strelchuk Sergii , Arvidsson-Shukur David
Published: May 2023

Measurements of quantum states form a key component in quantum-information processing. It is therefore an important task to compare measurements and furthermore decide if a measurement strategy is optimal. Entropic quantities, such as the quantum Fisher information, capture asymptotic optimality but not optimality with finite resources. We introduce a framework that allows one to conclusively establish if a measurement is optimal in the non-asymptotic regime. Our method relies on the fundamental property of expected errors of estimators, known as risk, and it does not involve optimisation over entropic quantities. The framework applies to finite sample sizes and lack of prior knowledge, as well as to the asymptotic and Bayesian settings. We prove a no-go theorem that shows that only classical states admit optimal measurements under the most common choice of error measurement: least squares. We further consider the less restrictive notion of an approximately optimal measurement and give sufficient conditions for such measurements to exist. Finally, we generalise the notion of when an estimator is inadmissible (i.e. strictly worse than an alternative), and provide two sufficient conditions for a measurement to be inadmissible.
Factores que impactan la seguridad ciudadana en la localidad de Kennedy, Bogotá D. C. (2019–2021)
Authors:   Policía Nacional de Colombia, Luis Carlos Cervantes Estrada , Oscar Andrés Moreno Moreno ,   Policía Nacional de Colombia, Andrés Felipe Rojas Ome ,   Policía Nacional de Colombia
Published: May 2023

Este libro es el resultado de dos investigaciones adelantadas en el 2021 en el marco de la primera cohorte de la Maestría en Convivencia y Seguridad Ciudadana de la Es-cuela de Cadetes de Policía “General Francisco de Paula Santander” [ECSAN]. Se tomó como unidad de análisis una de las localidades insigne de la capital de la República de Colombia, la número 8, Kennedy, una de las más extensas y pobladas del distrito, asimismo, según datos del Observatorio de Seguridad de la Cámara de Comercio de Bogotá (2020), la localidad cuenta con altos índices de delitos como el hurto a vehículos, asaltos bancarios, hurto a residencias y establecimientos comerciales, atraco a personas y riñas callejeras. Esta publicación aborda dos problemáticas que afectan actualmente a los habitantes y población flotante de la localidad, como es el hurto a bicicletas y la migración venezolana. Las conclusiones de los estudios aportan elementos de análisis, que sirven como insumo para que las autoridades locales y de policía formulen planes, programas y proyectos que permitan mejorar los niveles de convivencia y seguridad ciudadana en la localidad.
La complejidad del gambito legal al gambito literario
Authors: Cuesta Gomez Eliezer , González Ibarra Juan de Dios
Published: May 2023

En este artículo se elabora una aproximación a un fenómeno social, literario y artístico a partir de la complejidad y la epistemología. El fenómeno consiste en una demanda legal vigente a principios de 2022 que ha sido impuesta a los productores de la serie The Queen’s Gambit de Netflix. A los productores se les imputa una “mala” o “falsa” representación de la ajedrecista Nona Gaprindashvili en el universo ficcional desplegado por la serie durante un instante en el último episodio. En este sentido, el artículo revisa las implicaciones que este señalamiento legal, proveniente del exterior de la obra, irrumpe en el interior de la serie y se extiende a los múltiples intertextos o universos de realidades potenciales, para recriminar representaciones “incorrectas” de sujetos vivos en un mundo ficcional. Es decir, se estudia la mezcla multidimensional entre la realidad y la ficción, a partir de este fenómeno y cómo repercute una en la otra, además de sus alcances.
Concept and Implementation of Islamic Education in Islamic Education Institutions in Indonesia
Authors: Fathurrohman Rizal , Arif Mahmud , Sirait Sangkot
Published: May 2023

It seems that Islamic Religious Education (PAI), which is intended to instill Islamic ideals and noble morals in the whole process to produce authentic and noble Muslim people, has not materialized outwardly. The video showing students in North Sumatra brutally attacking a grandmother on the side of the road suddenly becomes a fact on the ground that does not reflect good character. Departing from this problem, the author wants to explain the concept and implementation of PAI in Islamic educational institutions in Indonesia. From these problems, the author wants to explain the concept and implementation of PAI in Islamic educational institutions in Indonesia. The combination of qualitative research and literature design is the approach taken to answer this research problem. Following are the findings of this study. 1), PAI implementation does not always run smoothly due to the following factors. First, PAI is less effective in fostering student morale. Second, the lack of understanding among students who practice the principles of their religion. Third, many students, including lecturers, are exposed to radicalism. Fourth, there is religious ritualism (individual piety). Meanwhile, the implementation of PAI as a subject in pesantren and madrasas is almost the same, it's just that in pesantren it uses more literal references to the yellow book, in contrast to madrasas which use textbooks published by the Ministry of Religion. Whereas in Islamic schools, the PAI materials are arranged with materials from the tarbiyah movement, as a distinct characteristic. While the implementation of PAI in PTKI, is built into several materials, namely, Al-Qur'an, Hadith, Akidah, and Morals courses.
Implementación del teletrabajo en el rendimiento laboral del personal de la Dirección Mantenimiento Institucional de la Caja Costarricense de Seguro Social, según la herramienta FODA, en el periodo 2019 al 2021
Authors: Lara Salas Alba
Published: May 2023

RESUMEN

El 2020 fue un año decisivo para todas las organizaciones públicas en lo que respecta a la definición del teletrabajo; como consecuencia de que la pandemia fue el impulso para tomar la decisión definitiva respecto a la implementación de este en las actividades.  En el ámbito de la Caja Costarricense de Seguro Social durante el mismo periodo, se llevó a cabo un trabajo arduo para ejecutar acciones respecto a la implementación del teletrabajo en la prestación de sus servicios; no solamente desde el aspecto meramente tecnológico, sino en aquellos servicios de los que se creía que no tendrían posibilidad de que  esta modalidad llegara a ser un mecanismo efectivo tanto para el desarrollo de la atención en salud como para otros servicios de apoyo como las labores administrativas de mantenimiento.  Mediante un enfoque mixto de la investigación, se logra analizar la implementación del teletrabajo en cuanto al rendimiento laboral del personal de la Dirección Mantenimiento Institucional de la Caja Costarricense de Seguro Social según los resultados de la herramienta FODA, en el periodo 2019 al 2021.  Las valoraciones realizadas con la herramienta FODA dan respuesta a la situación del fenómeno de estudio mediante la identificación de nueve fortalezas obtenidas del teletrabajo, seis oportunidades y mismo número para las amenazas; finalmente, se determinaron cinco debilidades.  Así mismo estos resultados permitieron conocer factores como la salud, aspectos tecnológicos y la relación trabajo – familia, y que de estos, a su vez se derivan variables características asociadas a cada factor como lo son: satisfacción o insatisfacción laboral, estrés, ausentismo, atención del hogar y familia, ambiente de trabajo e Internet; siendo que este conjunto conlleva a implicaciones positivas y negativas del teletrabajo para la población de la dirección; brindando a los interesados una información objetiva y oportuna para la toma de decisiones para mejorar en el uso de los recursos humanos, económicos y tecnológicos.  Si bien es cierto, este ha sido objeto de múltiples investigaciones en todos los contextos de cada país; al igual que las generaciones, este se enfrenta a constantes cambios para bien o para mal, debido a los avances tecnológicos, accesos a la información y a la formación de los nuevos profesionales de las distintas disciplinas
Introduction to speech communication
Authors: Hollingsworth Sarah , Weinland Kathryn , Hanrahan Sasha , Walker Mary , Elwood Errisa , Lisenmeyer Megan
Published: May 2023

Introduction to Speech Communication is used to support teaching, learning and research for SPCH 2713 at Oklahoma State University (OSU). In addition to inclusion of original work authored by the editors to meet the needs of their course at OSU, the editors adapted portions of Exploring Public Speaking: 4th Edition, Stand Up, Speak Out, and Fundamentals of Public Speaking. Please see the Acknowledgements chapter for full citations. We at Oklahoma State University Libraries acknowledge our gratitude for the expertise and generosity of the scholars at Affordable Learning Georgia, College of the Canyons, the Open Education Network and elsewhere for creating and sharing customizable versions of their work.
The story of dinosaurs ﻿
Authors: Burkett Ashley
Published: May 2023

This resource will explore the validity of arguments and/or conclusions in dinosaur research through evaluating the scientific evidence. Students using this resource will read, experiment, and evaluate scientific literature surrounding dinosaurs. Students will have the opportunity to work with others to evaluate the plausibility of the dinosaur concepts and theories, and engage in hands-on experiments to add additional information to their interpretations. Students will learn to participate in evaluation mechanisms to assess critical thinking and science literacy.
Does Metformin Therapy Affect Thyroid Function Tests in Euthyroid Obese Adolescents?
Authors: Ata Aysun , Balki Hanife Gül , Özen Samim , Gökşen Damla , Darcan Şükran
Published: May 2023

Background Metformin has been frequently used off-label for childhood
obesity besides diabetes. Studies have demonstrated the
thyroid-stimulating hormone (TSH) suppressive effect of metformin in
patients with a diagnosis of primary hypothyroidism. This study aimed to
evaluate free T4 (fT4) and free T3 (fT3) tests and influencing factors
in adolescents (TSH) who were on metformin therapy for obesity and
insulin resistance and had no diagnosed thyroid disease. Material and
Methods A total of 54 patients aged 10-18 years who presented to the
Pediatric Endocrinology Outpatient Clinic for overweight between 2017
and 2020 and who were diagnosed with exogenous obesity and insulin
resistance based on examinations by excluding hypothyroidism were
retrospectively evaluated. Baseline and post-treatment 6-month thyroid
function tests, HOMA-IR, and anthropometric measurements were evaluated.
Results Of the 54 patients included in the study, 38 (70.4%) were
female and 16 (29.6%) were male. the mean time from admission to
follow-up was 6.5±2.7 months. There was a moderate negative (inverse)
correlation between the change in weight SDS (∆weight SDS) and the
change in fT4 (∆fT4) of the patients (r=-0.319), and a moderate positive
correlation between ∆weight SDS and the change in fT3 value (∆fT3)
(r=0.534) (p=0.035; p=0.027, respectively). A moderate significant
positive correlation was found between the change in HOMA-IR (∆HOMA-IR)
and the change in TSH (∆TSH) (r=0.376; p=0.009).