bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Single-Nucleotide Polymorphisms on Clinical Outcomes of Capecitabine-Based Chemotherapy in Colorectal Cancer Patients: A Systematic Review
Authors: Cura Yasmin , Pérez-Ramírez Cristina , Sánchez-Martín Almudena , Membrive-Jimenez Cristina , Valverde-Merino María Isabel , González-Flores Encarnación , Morales Alberto Jiménez
Published: March 2023

The aim of this systematic review was to provide a comprehensive overview of the literature published in the last decade on the association of single-nucleotide polymorphisms in genes involved in the pharmacodynamic and pharmacokinetic pathways of capecitabine with treatment outcomes among colorectal cancer patients. A systematic search of the literature published in the last 10 years was carried out in two databases (Medline and Scopus) using keywords related to the objective. Quality assessment of the studies included was performed using an assessment tool derived from the Strengthening the Reporting of Genetic Association (STREGA) statement. Thirteen studies were included in this systematic review. Genes involved in bioactivation, metabolism, transport, mechanism of action of capecitabine, DNA repair, and folate cycle were associated with toxicity. Meanwhile, genes related to DNA repair were associated with therapy effectiveness. This systematic review reveals that several SNPs other than the four DPYD variants that are screened in clinical practice could have an impact on treatment outcomes. These findings suggest the identification of future predictive biomarkers of effectiveness and toxicity in colorectal cancer patients treated with capecitabine. However, the evidence is sparse and requires further validation.
Synthesis of N-Substituted Pyrroles Catalyzed by Low-Cost and Commercially Available Aluminas
Authors: Portilla-Zúñiga Omar , Bautista-Aguilera Óscar , Martínez José , Rojas Hugo , Macías Mario , Iriepa Isabel , Pérez-Redondo Adrián , Sathicq Ángel , Castillo Juan-Carlos , Romanelli Gustavo
Published: March 2023

The Paal-Knorr reaction of acetonylacetone with primary amines catalyzed by CATAPAL 200 under conventional heating at 60 °C for 45 min afforded N-substituted pyrroles in 68–97% yields. The pyrrole 3g was studied by single-crystal and powder X-ray diffraction. The high percentage of Brønsted–Lewis acid sites (23%) and pore diameter (37.8 nm) of CATAPAL 200 favor the formation of the pyrrole ring because an increase in Brønsted acid sites efficiently catalyzes condensation and dehydration processes. This protocol is distinguished by its operational simplicity, high yields, reduced reaction time, no solvent required, stoichiometric amounts of reactants, low catalyst loading, and clean reaction profile. In addition, the CATAPAL 200 is cheap and commercially available leading to an efficient and lower-cost chemical transformation. The reusability of the catalyst for up to five cycles without appreciable loss of its catalytic activity makes the present protocol sustainable and advantageous compared to conventional methods.
Prader–Willi Syndrome and Weight Gain Control: From Prevention to Surgery—A Narrative Review
Authors: Calcaterra Valeria , Magenes Vittoria Carlotta , Destro Francesca , Baldassarre Paola , Silvestro Giustino Simone , Tricella Chiara , Visioli Alessandro , Verduci Elvira , Pelizzo Gloria , Zuccotti Gianvincenzo
Published: March 2023

Severe obesity remains one of the most important symptoms of Prader–Willi Syndrome (PWS), and controlling weight represents a crucial point in the therapeutical approach to the syndrome. We present an overview of different progressive patterns of growth that involve controlling weight in PWS. Mechanisms involved in the development of obesity and in preventive and therapeutic strategies to control weight gain are discussed. Early diagnosis, a controlled diet regimen, regular physical activity, follow-up by multidisciplinary teams, and hormonal treatment improved the management of excessive weight gain. In selected cases, a surgical approach can be also considered. Controlling weight in PWS remains a challenge for pediatricians. The importance of consulting different healthcare specialists, starting from the neonatal and pediatric age, is also considered as a crucial approach to controlling weight, as well as to limiting and preventing the onset of obesity and its complications.
Parental Pre and Postnatal Depression: The Longitudinal Associations with Child Negative Affectivity and Dysfunctional Mother–Child Feeding Interactions
Authors: Lucarelli Loredana , Vismara Laura , Chatoor Irene , Sechi Cristina
Published: March 2023

Background: Many studies have shown the influence of maternal perinatal depression on a child’s emotional and behavioral regulation ability; yet there is scarce research on the impact of the father’s perinatal depression on the caregiver–infant relationship and the child’s development. Methods: Through a longitudinal study, we investigated maternal and paternal depression and its association with infants’ emotionality and mother–infant feeding interactions The sample was constituted of 136 first-time parents (68 couples, and their full-term babies at 3 and 6 months old). At T1 (28th week of pregnancy), T2 (three months old), and T3 (at six months age) parents responded to the Edinburgh Postpartum Depression Scale. At Times 2 and 3, mothers and fathers completed the Infant Behavior Questionnaire, and recorded mother–infant interactions were coded by means of the Feeding Scale. Results: Statistical analyses indicated stability of maternal and paternal depression over time. Correlations emerged between mother’s higher depression scores, negative affective state during interactions at three months age, infant food refusal and mother–infant interactional conflict at six months age. Paternal higher depressive scores were associated with the mother–child interactional conflict. To finish, higher parental depression scores were related with infant negative emotionality. Conclusion: The current study confirms the relevance of embracing a cumulative risk model to support the child’s development with early caregiver-child interventions.
Health Outcomes of Children Living in Out-of-Home Care in Metropolitan Western Australia: A Sequential Mixed-Methods Study—A Protocol Paper
Authors: Kachila Hope , Bulsara Caroline , Farrant Brad , Johnson Alice , Michie Carol , Pell Charmaine
Published: March 2023

The research protocol described aims to examine and establish the health outcomes of children and young people living in Out-of-Home Care (OOHC) in Perth, Western Australia (WA) from the perspective of the care recipients and service providers. A Study Advisory Panel (SAP) will be established comprised of Aboriginal Elders (because of the over-representation of Aboriginal children in OOHC), health professionals and other relevant stakeholders to help co-design all phases of the study. Mixed methods will be used in data collection and analysis. In the quantitative phase, it is proposed to collect retrospective data from three WA Department of Communities (DOC) districts. The data proposed to be collected includes: the number of children who received initial and annual health assessments, the health needs identified, and interventions put in place to address these needs. The qualitative phase will consist of interviews with service recipients (young people who have exited OOHC and Carers), health service providers (Community Health Nurses, School Nurses, General Practitioners and Paediatricians) and OOHC Case Workers. The research will provide an overview of the current health needs of children and young people in OOHC in WA and the perspectives of these young people, their Carers and service providers on current processes for accessing healthcare. It is anticipated that the study will provide valuable evidence for quality improvement in health service delivery to better meet the health needs of children and young people in OOHC.
Social Acceptance in Physical Education and the Regular Classroom: Perceived Motor Competency and Frequency and Type of Sports Participation
Authors: de Bruijn Anne G. M. , van der Wilt Femke
Published: March 2023

This study examined relations of primary school children’s perceived physical competence and sports participation (frequency and type) with social acceptance in the regular classroom and physical education (PE) and whether these relations differed depending on the type of sport children participated in (team vs. individual sports). In total, 182 children (48.9% boys, mean age 9.90 years, SD = 1.23) filled out questions on their perceived physical competence and sports participation and indicated three peers with whom they liked/disliked working in PE and the regular classroom. Multilevel structural equation models in Mplus showed that frequency of sports participation was positively related to social acceptance in the context of PE. Additionally, for children in team sports, the frequency of sports participation was related to their social acceptance in PE, whereas for children in individual sports, perceived physical competence was related to social acceptance in PE. No relations were found in the regular classroom. Relations of perceived physical competence and sports participation with social acceptance seem to depend on the school context and the type of sport involved. In designing PE classrooms, children’s physical competence and sports participation seem essential factors to take into account to provide all children with positive social experiences.
Appendicitis and Peritonitis in Children with a Ventriculo-Peritoneal Shunt
Authors: Fröschle Glenn M. C. , Hagens Johanna , Mannweiler Philip , Groth Friederike Sophie , Kammler Gertrud , Reinshagen Konrad , Tomuschat Christian
Published: March 2023

The purpose of this study was to outline the management of patients with appendicitis and ventriculoperitoneal shunt (VPS) in the largest pediatric surgery department in Germany. Patients with VPS presenting with an acute abdomen between 2012 and 2022 at a tertiary-care pediatric facility were the subject of a retrospective descriptive analysis. Patients were divided into two groups based on their diagnoses: group A (appendicitis) and group B (primary peritonitis). Medical records were analyzed to look at the diagnostics, operative approach, complications, peritoneal and liquor culture, and antibiotic treatment. A total of seventeen patients were examined: seven patients in group A and ten individuals in group B. In the present study patients in group A typically presented younger, sicker, and with more neurological symptoms than those in group B. All patients with appendicitis had their VPS exteriorized, and a new shunt system into the peritoneum was reimplanted 20 days later. Surgery should be aggressively administered to patients who present with an acute abdomen and a VPS. Change of the whole shunt system is suggested. Shunt infection and dysfunction should be ruled out in patients with abdominal symptoms, and surgical care should be started with a low threshold.
Multimedia Mixed Reality Interactive Shared Decision-Making Game in Children with Moderate to Severe Atopic Dermatitis, a Pilot Study
Authors: Chang Ling-Sai , Kuo Ho-Chang , Suen Jason Jyh-Bin , Yang Pei-Hsin , Hou Chiu-Ping , Sun Hui-Ru , Lee Zon-Min , Huang Ying-Hsien
Published: March 2023

(1) Objective: Atopic dermatitis (AD) is a recurring skin disease that affects children’s daily activities and sleep quality. Due to the limitations of children’s understanding and ability to express themselves, shared decision making (SDM) is often made by guardians, which thus affects the acceptance and effectiveness of children’s treatments. Previous studies have demonstrated that involving both children and parents in decision making may help improve treatment outcomes; thus, we designed a multimedia mixed reality (MR) interactive game of SDM for children with moderate to severe AD. (2) Methods: Research participants included 6–18-year-old patients with moderate to severe AD. This research consisted of the following steps: designing SDM; character setting and visual design; performing games; system modification and optimization; screen editing and dubbing; and user testing and questionnaires by the System Usability Scale (SUS). (3) Results: We completed the SDM design for children with moderate to severe AD. Four different treatments were biologics, oral immune-modulating drugs, phototherapy, and wet wrap. An animated PowerPoint slide showed the AD apple rolling around before treatments and the AD apple sleeping soundly after treatments. Instructions with video teaching for the four different treatments were played, and then, the MR was turned on so that the patients could help the AD apple in the metaverse to undergo these four treatments. A total of 12 moderate to severe AD patients and six control patients used the game, all aged between six and eighteen years old, with an average SUS score of 81.0 and a standard error of 2.1 points. Adjective ratings yielded a rating between good and excellent. The game showed acceptable usability. We found no statistically significant differences in SUS scores between patients with and without moderate to severe AD or between boys and girls nor significant associations between SUS and age or severity. The analysis identified that the two items with the lowest SUS scores were “I think that I would need the support of a technical person to be able to use this product” and “I needed to learn a lot of things before I could get going with this product”. Both of these comments show the limitations of this game. (4) Conclusions: Overall, this study provides the first MR SDM game that has passed the SUS and can be used as an aid in clinical SDM.
Efficacy of Artificial Intelligence in the Categorisation of Paediatric Pneumonia on Chest Radiographs: A Systematic Review
Authors: Field Erica Louise , Tam Winnie , Moore Niamh , McEntee Mark
Published: March 2023

This study aimed to systematically review the literature to synthesise and summarise the evidence surrounding the efficacy of artificial intelligence (AI) in classifying paediatric pneumonia on chest radiographs (CXRs). Following the initial search of studies that matched the pre-set criteria, their data were extracted using a data extraction tool, and the included studies were assessed via critical appraisal tools and risk of bias. Results were accumulated, and outcome measures analysed included sensitivity, specificity, accuracy, and area under the curve (AUC). Five studies met the inclusion criteria. The highest sensitivity was by an ensemble AI algorithm (96.3%). DenseNet201 obtained the highest level of specificity and accuracy (94%, 95%). The most outstanding AUC value was achieved by the VGG16 algorithm (96.2%). Some of the AI models achieved close to 100% diagnostic accuracy. To assess the efficacy of AI in a clinical setting, these AI models should be compared to that of radiologists. The included and evaluated AI algorithms showed promising results. These algorithms can potentially ease and speed up diagnosis once the studies are replicated and their performances are assessed in clinical settings, potentially saving millions of lives.
Frasier Syndrome: A 15-Year-Old Phenotypically Female Adolescent Presenting with Delayed Puberty and Nephropathy
Authors: Shao Qing , Xie Xinglei , Geng Jia , Yang Xiaoling , Li Wei , Zhang Yuwei
Published: March 2023

Frasier syndrome (FS) is a rare inherited disorder characterized by gonadal dysgenesis and progressive nephropathy, resulting from mutations in the intron 9 splice donor site of the Wilms tumor 1 (WT1) gene. It is associated with male gonadal dysgenesis (female external genitalia with a 46 XY karyotype), and a high risk of gonadoblastoma during adolescence. Patients with FS present early in childhood with proteinuria that progressively worsens with a high likelihood of end-stage renal disease (ESRD). Herein, we report a 15-year-old female (karyotype 46, XY) patient characterized by delayed puberty and steroid-resistant nephrotic syndrome, in whom whole genome sequencing showed a mutation in intron 9 of the WT1 gene, c.1447 + 4 C>T. This is the first case of FS with delayed puberty as the first complaint with no previous renal symptoms. We consider delayed puberty as an important manifestation of FS and summarize the diagnostic process of delayed puberty in the female phenotype. For clinicians, delayed puberty is a common disorder in pediatrics but requires vigilance for some rare causes. Etiological screening and chromosome karyotype analysis are important for the early diagnosis of FS in patients with delayed puberty.
Ubiquitin Is Not a Blood Biomarker of an Early Cognitive Decline in the Polish Elderly
Authors: McFarlane Oliwia , Kozakiewicz Mariusz , Wojciechowska Milena , Kędziora-Kornatowska Kornelia
Published: March 2023

Together with development of new pharmaceutical interventions, as well as the introduction of the concept of initial dementia phase, the demand for early diagnosis has been growing. Research on potential blood biomarkers, amazingly attractive, mainly due to the facility of deriving the material, has provided ambiguous results throughout. The existence of an association between ubiquitin and Alzheimer’s disease pathology suggests that it could be a potential neurodegeneration biomarker. The present study aims to identify and assess the relationship between ubiquitin with regard to the adequacy as a biomarker of an initial dementia and cognitive decline in the elderly. Method: The study sample was composed of 230 participants: 109 women and 121 men aged 65 and older. The relationships of plasma ubiquitin levels with cognitive performance, gender, and age were analyzed. The assessments were performed in three groups of cognitive functioning level: cognitively normal, mild cognitive impairment, and mild dementia, of which the subjects were divided with the Mini-Mental State Examination (MMSE). Results: No significant disparities in plasma ubiquitin levels for various levels of cognitive functioning were identified. Significantly higher plasma ubiquitin levels in women were found in comparison to men. No significant differences were found in ubiquitin concentrations based on age. Results suggest that ubiquitin does not meet the requirements for qualification as a blood biomarker of an early cognitive decline. In order to thoroughly evaluate the potential of research on ubiquitin in connection to an early neurodegenerative process, further studies are needed.
Sea Level Variability in the Equatorial Malacca Strait: The Influence of Climatic–Oceanographic Factors and Its Implications for Tidal Properties in the Estuarine Zone
Authors: Wisha Ulung Jantama , Wijaya Yusuf Jati , Hisaki Yukiharu
Published: March 2023

The sea level trend in the equatorial Malacca Strait is a significant issue that needs to be reviewed since it is an area of interest. Assessing its future impact on estuarine tidal characteristics is worth studying because it relates to the potency of coastal damages. This study aimed to discuss the relationship between sea level variations and anomalies and their possible triggering factors and to estimate the future impacts on the tidal properties in the estuarine zone. Tide gauge and altimetry data in the Tanjong Pagar site were used to assess the sea level trends over 27 years of observation (from 1992 to 2019). Both altimetry and tide gauge data showed an upward trend, with 0.24 cm/year and 0.39 cm/year, respectively. Due to the near-equatorial area of interest, sea level variability is more synchronized with ENSO rather than IOD. At some points, ENSO shapes the sea level fluctuation, with an R2 of less than 10%. For specific periods, the coupling effects between MJO and La Niña may trigger higher evaporation in the maritime continent, triggering increasing sea levels. Of particular concern, among the other assessed factors, the zonal currents and winds (wind-driven currents) are strongly correlated with sea level variations, primarily during the NE monsoon and the second transitional periods, with a determination coefficient of about 18–36%. As a result of sea level rises, it is estimated that tidal constituent amplitudes will increase by about 8.9% and 18.3% in 2050 and 2100, respectively. The increase in tidal range will possibly relate to the tidal bore passage in the Kampar estuary. Therefore, more advanced hydrodynamic modeling is necessary to determine the impact of sea level rises on tidal bore generation.
Topography, Slope and Geomorphology’s Influences on Shoreline Dynamics along Dakar’s Southern Coast, Senegal
Authors: Pouye Ibrahima , Adjoussi Dieudonné Pessièzoum , Ndione Jacques André , Sall Amadou
Published: March 2023

Among the impacts of climate change in West Africa, coastal erosion is the most threatening disaster apart from floods and the increase in temperatures. The southern coast of the Dakar region, as part of the most threatened coastal zones in West Africa, records the most current coastal damages in Dakar due to its coastline dynamics and low-lying area. This paper investigates the influences of the topography and slope of the beach on shoreline dynamics using remote sensing, cartographic tools and statistical methods such as linear regression. It also states the important role of geomorphologic structures in shoreline dynamics. It was conducted in three littoral cells (Mbao, Bargny and Toubab Dialaw) along the southern coast of Dakar. It helps to understand better the role that topography, slope and geomorphology play in coastal dynamics. The Modified Normalized Difference Water Index (MNDWI) was employed to delineate the coastlines before computing the dynamic rate of the coastline using Digital Shoreline Analysis System (DSAS) software. After that, the topography and slope were determined using a digital elevation model (DEM). Then, the correlation between the coastline dynamic, topography and slope was analyzed using the coefficient of correlation and linear regression model. In the Mbao and Bargny littoral cells where the geomorphology is mostly dominated by soils little or not evolved in situ, there is a significant relationship between the coast line dynamic, topography and slope with a coefficient of correlation of about 0.63 and 0.87, respectively. The relationship is not significant in Toubab Dialaw, where the topography and slope are high, and the geomorphology is mainly characterized by a category of sandstone, with a coefficient of 0.15. We conclude that topography, slope and geomorphology play an important role in the shoreline dynamics in the study area.
Structure Evolution of Nanocrystalline–Amorphous TiAl Biphase Films during Helium Ion Implantation
Authors: Liu Pei , Tian Lifeng , Li Xuanze , Cao Jianyu , Ma Yutian , Meng Xiangmin
Published: March 2023

Building nanocrystalline–amorphous biphase nanostructure has recently emerged as an advanced route to improve radiation tolerance, as the nanocrystalline–amorphous interface is expected to enhance the sink efficiencies of helium atoms. However, the structure evolution and degradation mechanisms during helium ion implantation in nanocrystalline–amorphous biphase films are still unclear. This study aimed to further understand these mechanisms through in situ observation of nanocrystalline–amorphous TiAl biphase films deposited via magnetron sputtering in a helium ion microscope. Results demonstrate that during the helium implantation process (the final fluence was 4 × 1017 ions cm−2), a partial swelling occurred in the implantation region without blisters, cracks, or exfoliation on the surface. The AFM and TEM results revealed that the partial bulge originated from the differential in the swelling rate between the amorphous and grain areas during helium ion implantation. These findings offer promising insights into designing radiation-tolerant materials for advanced nuclear reactors.
Impact of Operating Parameters on the Production of Nanoemulsions Using a High-Pressure Homogenizer with Flow Pattern and Back Pressure Control
Authors: Zhou Hualu , Qin Dingkui , Vu Giang , McClements David Julian
Published: March 2023

The main objective of this study was to establish the relative importance of the main operating parameters impacting the formation of food-grade oil-in-water nanoemulsions by high-pressure homogenization. The goal of this unit operation was to create uniform and stable emulsified products with small mean particle diameters and narrow polydispersity indices. In this study, we examined the performance of a new commercial high-pressure valve homogenizer, which has several features that provide good control over the particle size distribution of nanoemulsions, including variable homogenization pressures (up to 45,000 psi), nozzle dimensions (0.13/0.22 mm), flow patterns (parallel/reverse), and back pressures. The impact of homogenization pressure, number of passes, flow pattern, nozzle dimensions, back pressure, oil concentration, emulsifier concentration, and emulsifier type on the particle size distribution of corn oil-in-water emulsions was systematically examined. The droplet size decreased with increasing homogenization pressure, number of passes, back pressure, and emulsifier-to-oil ratio. Moreover, it was slightly smaller when a reverse rather than parallel flow profile was used. The emulsifying performance of plant, animal, and synthetic emulsifiers was compared because there is increasing interest in replacing animal and synthetic emulsifiers with plant-based ones in the food industry. Under fixed homogenization conditions, the mean particle diameter decreased in the following order: gum arabic (0.66 µm) > soy protein (0.18 µm) > whey protein (0.14 µm) ≈ Tween 20 (0.14 µm). The information reported in this study is useful for the optimization of the production of food-grade nanoemulsions using high-pressure homogenization.
Influence of the Triglyceride Composition, Surfactant Concentration and Time–Temperature Conditions on the Particle Morphology in Dispersions
Authors: Reiner Jasmin , Martin Désirée , Ott Franziska , Harnisch Leon , Gaukel Volker , Karbstein Heike Petra
Published: March 2023

Many applications for crystalline triglyceride-in-water dispersions exist in the life sciences and pharmaceutical industries. The main dispersion structures influencing product properties are the particle morphology and size distribution. These can be set by the formulation and process parameters, but temperature fluctuations may alter them afterwards. As the dispersed phase often consists of complex fats, there are many formulation variables influencing these product properties. In this study, we aimed to gain a better understanding of the influence of the dispersed-phase composition on the crystallization and melting behavior of these systems. We found that different particle morphologies can be obtained by varying the dispersed-phase composition. Droplets smaller than 1 µm were obtained after melting due to self-emulsification (SE), but these changes and coalescence events were only partly influenced by the melting range of the fat. With increasing surfactant concentration, the SE tendency increased. The smallest x50,3 of 3 µm was obtained with a surfactant concentration of 0.5 wt%. We attributed this to different mechanisms leading to the droplets’ breakup during melting, which we observed via thermo-optical microscopy. In addition, SE and coalescence are a function of the cooling and heating profiles. With slow heating (0.5 K/min), both phenomena are more pronounced, as the particles have more time to undergo the required mechanisms.
Acknowledgment to the Reviewers of Colorants in 2022
Authors:   Colorants Editorial Office
Published: March 2023

High-quality academic publishing is built on rigorous peer review [...]
Synthesis and Spectral, Thermal and Antimicrobial Investigation of Mixed Ligand Metal Complexes of N-Salicylidene Aniline and 1,10-Phenanthroline
Authors: Mohamed Amira A. , Nassr Abeer A. , Sadeek Sadeek A. , Elshafie Hazem S.
Published: March 2023

Coordination compounds of Co(II), Cu(II), Y(III), Zr(IV) and La(III) ions were synthesized from the N-salicylidene aniline (L) derived from the condensation of aniline with salicylaldhyde and 1,10-phenanthroline (phen) as a secondary mixed ligand. L, phen and their complexes were characterized using various physiochemical methods, such as elemental analyses (CHN), Fourier-transform infrared spectroscopy (FT-IR), molar conductance (Λ), magnetic susceptibility (μeff), proton nuclear magnetic resonance (1H NMR), ultraviolet–visible spectroscopy (UV–Vis) and thermogravimetric analysis (TG/DTG). The analytical and spectroscopic data supporting the chemical formulas of the metal complexes and chelation of L and phen with the metal ions forming octahedral complexes. FT-IR spectra demonstrated that L chelated with metal ions as a bidentate ligand via the oxygen atom of the phenolic group with a band in the range 3378–3437 cm−1 and the nitrogen atom of the azomethine group at 1612 cm−1. In addition, phen chelated through two nitrogen atoms in the range 1525–1565 cm−1. The 1H NMR results confirmed the IR assumption that the ligand connected to the metal ions via the phenolic’s oxygen atom. The molar conductance measurements of the complexes revealed high values of the electrolytic nature of these complexes in the range of 90.40–125.80 S cm2 mol−1. Thermal analysis (TG/DTG) was used to differentiate between coordinated and hydrated water molecules and the thermal stability of the complexes. Finally, the anti-microbial activities of the complexes were investigated against fungi (Candida albicans), Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) and Gram-positive bacteria (Staphylococcus aureus and Micrococcus sp.) using the disc diffusion method. The La(III) complex was significant against C. albicans compared with all other compounds and reference standard control.
Hydrogen Embrittlement Failure Behavior of Fatigue-Damaged Welded TC4 Alloy Joints
Authors: Feng Xudong , Shi Yu , Zhang Wenzhu , Volodymyr Korzhyk
Published: March 2023

The interaction between fatigue damage and hydrogen in TC4 welded joints was analyzed considering specimens with different pre-cycles. The fracture failure caused by hydrogen-induced fatigue damage was investigated using tensile testing and microstructural observations. The results indicate that increasing the number of pre-cycles increases the specimens’ initial dislocation density, enhancing the severity of the hydrogen-induced embrittlement phenomenon. The hydrogen-enhanced local plasticity mechanism, manifested by fracture along the grain boundary, dominates the tensile process in fatigue-damaged hydrogen-filled welded joints after 10,000 and 20,000 pre-cycles. After 30,000 pre-cycles, the hydrogen-enhanced decohesion mechanism dominates the tensile process, manifesting as a transgranular cleavage decoupling fracture.
An Invisible Boundary between Geographic Ranges of Cryptic Species of Narrow-Headed Voles (Stenocranius, Lasiopodomys, Cricetidae) in Transbaikalia
Authors: Petrova Tatyana V. , Dvoyashov Ivan A. , Bazhenov Yury A. , Obolenskaya Ekaterina V. , Lissovsky Andrey A.
Published: March 2023

The narrow-headed vole species complex is represented by Lasiopodomys gregalis and L. raddei, which probably diverged at the beginning of the Middle Pleistocene and came into secondary contact in the Transbaikal region. The current study analyzed mitochondrial gene cytochrome b, nuclear gene BRCA1, and microsatellite data and was aimed at clarifying geographic ranges of these species and searching for hybrid zones between them. It turned out that the geographic range of L. raddei is almost surrounded by that of L. gregalis; these species are strictly parapatric without a single detected sympatry zone. Although in none of the tested populations did the BRCA1 genotyping contradict the pattern revealed by mitochondrial cytb, microsatellite loci showed traces of hybridization in several populations. Results of species distribution modeling indicated that these species are characterized by quite similar (caused by the same environmental factors), but nevertheless significantly different, ecological preferences.
Optimal Hybridization with Minimum Fuel Consumption of the Hybrid Fuel Cell Train
Authors: Mišić Mario , Stojkov Marinko , Tomić Rudolf , Lovrić Mario
Published: March 2023

This paper describes a numerical study of the optimal distribution of energy between fuel cells and auxiliary energy storages in the hybrid train. Internal combustion engines (ICEs) are currently under pressure from environmental agencies due to their harmful gas emissions, and pure battery vehicles have a short range; a hybrid train powered by fuel cells, batteries, and supercapacitors can provide a viable propulsion solution. In this study, special energy management on the mountain railway with optimal power distribution and minimum hydrogen consumption is proposed. Considering the characteristics of the mountain railway, the vehicle uses recuperation of regenerative braking energy and thus charges additional power devices, and hybridization optimization gives favorable power to each power source device with a minimum consumption of hydrogen in the fuel cell. In this study, a simulation model was created in a Matlab/Simulink environment for the optimization of hybridized power systems on trains, and it can be easily modified for the hybridization of any type of train. Optimization was performed by using Sequential quadratic programming (SQP). The results show that this hybrid train topology has the ability to recover battery and supercapacitor state of charge (SOC) while meeting vehicle speed and propulsion power requirements. The effect of battery and supercapacitor parameters on power distribution and fuel consumption was also simulated.
Delaminated Tears of the Rotator Cuff: MRI Interpretation with Clinical Correlation
Authors: Kim Jun-Ho , Lee Seul Ki
Published: March 2023

(1) Background: A delaminated tear is described as a horizontal split in the tendon substance. This review summarizes the clinical and radiologic characteristics of delaminated tears of the rotator cuff. (2) Methods: Initial radiological characteristics of a delaminated tear include the horizontal component of a partial-thickness tear determined using magnetic resonance (MR) arthrography. As demonstrated using indirect MR arthrography, the tear gradually progresses to be defined as either horizontal intrasubstantial splitting of the bursal and articular layers or differential retraction of the bursal and articular layers. (3) Results: The existence of delaminated tears is a poor prognostic factor in functional and morphologic outcomes after the repair of rotator cuff tendons and many surgical techniques have been introduced to solve this problem. Although the presence of a delaminated tear does not affect the arthroscopic repair outcome, the presence of medium-to-large, retracted delaminated tears may be an adverse negative prognostic factor after single-row repair. (4) Conclusion: Advances in imaging and surgical techniques have improved the detection of delaminated rotator cuff tears. Preoperative identification of delaminated tears on magnetic resonance imaging is clinically important because tailored surgical repair techniques must be chosen for successful outcomes.
Ultrasound-Guided Interventions for Carpal Tunnel Syndrome: A Systematic Review and Meta-Analyses
Authors: Lam King Hei Stanley , Wu Yung-Tsan , Reeves Kenneth Dean , Galluccio Felice , Allam Abdallah El-Sayed , Peng Philip W. H.
Published: March 2023

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment, and recently, ultrasound-guided perineural injection (UPIT) and percutaneous flexor retinaculum release (UPCTR) have been utilized to treat CTS. However, no systematic review or meta-analysis has included both intervention types of ultrasound-guided interventions for CTS. Therefore, we performed this review using four databases (i.e., PubMed, EMBASE, Scopus, and Cochrane) to evaluate the quality of evidence, effectiveness, and safety of the published studies on ultrasound-guided interventions in CTS. Among sixty studies selected for systemic review, 20 randomized treatment comparison or controlled studies were included in six meta-analyses. Steroid UPIT with ultrasound guidance outperformed that with landmark guidance. UPIT with higher-dose steroids outperformed that with lower-dose steroids. UPIT with 5% dextrose in water (D5W) outperformed control injection and hydrodissection with high-volume D5W was superior to that with low-volume D5W. UPIT with platelet-rich plasma outperformed various control treatments. UPCTR outperformed open surgery in terms of symptom improvement but not functional improvement. No serious adverse events were reported in the studies reviewed. The findings suggest that both UPIT and UPCTR may provide clinically important benefits and appear safe. Further treatment comparison studies are required to determine comparative therapeutic efficacy.
End-to-End Automatic Classification of Retinal Vessel Based on Generative Adversarial Networks with Improved U-Net
Authors: Zhang Jieni , Yang Kun , Shen Zhufu , Sang Shengbo , Yuan Zhongyun , Hao Runfang , Zhang Qi , Cai Meiling
Published: March 2023

The retinal vessels in the human body are the only ones that can be observed directly by non-invasive imaging techniques. Retinal vessel morphology and structure are the important objects of concern for physicians in the early diagnosis and treatment of related diseases. The classification of retinal vessels has important guiding significance in the basic stage of diagnostic treatment. This paper proposes a novel method based on generative adversarial networks with improved U-Net, which can achieve synchronous automatic segmentation and classification of blood vessels by an end-to-end network. The proposed method avoids the dependency of the segmentation results in the multiple classification tasks. Moreover, the proposed method builds on an accurate classification of arteries and veins while also classifying arteriovenous crossings. The validity of the proposed method is evaluated on the RITE dataset: the accuracy of image comprehensive classification reaches 96.87%. The sensitivity and specificity of arteriovenous classification reach 91.78% and 97.25%. The results verify the effectiveness of the proposed method and show the competitive classification performance.
Cell-Free DNA in Plasma and Serum Indicates Disease Severity and Prognosis in Blunt Trauma Patients
Authors: Trulson Inga , Stahl Juliane , Margraf Stefan , Scholz Martin , Hoecherl Eduard , Wolf Konrad , Durner Juergen , Klawonn Frank , Holdenrieder Stefan
Published: March 2023

Background: Trauma is still a major cause of mortality in people < 50 years of age. Biomarkers are needed to estimate the severity of the condition and the patient outcome. Methods: Cell-free DNA (cfDNA) and further laboratory markers were determined in plasma and serum of 164 patients at time of admission to the emergency room. Among them were 64 patients with severe trauma (Injury Severity Score (ISS) ≥ 16), 51 patients with moderate trauma (ISS < 16) and 49 patients with single fractures (24 femur neck and 25 ankle fractures). Disease severity was objectified by ISS and Glasgow Coma Scale (GCS). Results: cfDNA levels in plasma and serum were significantly higher in patients with severe multiple trauma (SMT) than in those with moderate trauma (p = 0.002, p = 0.003, respectively) or with single fractures (each p < 0.001). CfDNA in plasma and serum correlated very strongly with each other (R = 0.91; p < 0.001). The AUC in ROC curves for identification of SMT patients was 0.76 and 0.74 for cfDNA in plasma and serum, respectively—this was further increased to 0.84 by the combination of cfDNA and hemoglobin. Within the group of multiple trauma patients, cfDNA levels were significantly higher in more severely injured patients and patients with severe traumatic brain injury (GCS ≤ 8 versus GCS > 8). Thirteen (20.3%) of the multiple trauma patients died during the first week after trauma. Levels of cfDNA were significantly higher in non-surviving patients than in survivors (p < 0.001), reaching an AUC of 0.81 for cfDNA in both, plasma and serum, which was further increased by the combination with hemoglobin and leukocytes. Conclusions: cfDNA is valuable for estimation of trauma severity and prognosis of trauma patients.
A Fragile Image Watermarking Scheme in DWT Domain Using Chaotic Sequences and Error-Correcting Codes
Authors: Ramos Andy M. , Artiles José A. P. , Chaves Daniel P. B. , Pimentel Cecilio
Published: March 2023

With the rapid development of digital signal processing tools, image contents can be easily manipulated or maliciously tampered with. Fragile watermarking has been largely used for content authentication purposes. This article presents a new proposal for image fragile watermarking algorithms for tamper detection and image recovery. The watermarked bits are obtained from the parity bits of an error-correcting code whose message is formed from a binary chaotic sequence (generated from a secret key known to all legitimate users) and from bits of the original image. Part of the codeword (the chaotic bits) is perfectly known to these users during the extraction phase, adding security and robustness to the watermarking method. The watermarked bits are inserted at specific sub-bands of the discrete wavelet transform of the original image and are used as authentication bits for the tamper detection process. The imperceptibility, detection, and recovery of this algorithm are tested for various common attacks over digital images. The proposed algorithm is analyzed for both grayscale and colored images. Comparison results reveal that the proposed technique performs better than some existing methods.
Improving the Performance and Stability of TIC and ICE
Authors: Ward Tyler
Published: March 2023

Takeuchi’s Information Criterion (TIC) was introduced as a generalization of Akaike’s Information Criterion (AIC) in 1976. Though TIC avoids many of AIC’s strict requirements and assumptions, it is only rarely used. One of the reasons for this is that the trace term introduced in TIC is numerically unstable and computationally expensive to compute. An extension of TIC called ICE was published in 2021, which allows this trace term to be used for model fitting (where it was primarily compared to L2 regularization) instead of just model selection. That paper also examined numerically stable and computationally efficient approximations that could be applied to TIC or ICE, but these approximations were only examined on small synthetic models. This paper applies and extends these approximations to larger models on real datasets for both TIC and ICE. This work shows the practical models may use TIC and ICE in a numerically stable way to achieve superior results at a reasonable computational cost.
Improving Text-to-SQL with a Hybrid Decoding Method
Authors: Jeong Geunyeong , Han Mirae , Kim Seulgi , Lee Yejin , Lee Joosang , Park Seongsik , Kim Harksoo
Published: March 2023

Text-to-SQL is a task that converts natural language questions into SQL queries. Recent text-to-SQL models employ two decoding methods: sketch-based and generation-based, but each has its own shortcomings. The sketch-based method has limitations in performance as it does not reflect the relevance between SQL elements, while the generation-based method may increase inference time and cause syntactic errors. Therefore, we propose a novel decoding method, Hybrid decoder, which combines both methods. This reflects inter-SQL element information and defines elements that can be generated, enabling the generation of syntactically accurate SQL queries. Additionally, we introduce a Value prediction module for predicting values in the WHERE clause. It simplifies the decoding process and reduces the size of vocabulary by predicting values at once, regardless of the number of conditions. The results of evaluating the significance of Hybrid decoder indicate that it improves performance by effectively incorporating mutual information among SQL elements, compared to the sketch-based method. It also efficiently generates SQL queries by simplifying the decoding process in the generation-based method. In addition, we design a new evaluation measure to evaluate if it generates syntactically correct SQL queries. The result demonstrates that the proposed model generates syntactically accurate SQL queries.
A New Quantum Private Protocol for Set Intersection Cardinality Based on a Quantum Homomorphic Encryption Scheme for Toffoli Gate
Authors: Liu Wen , Li Yangzhi , Wang Zhirao , Li Yugang
Published: March 2023

Set Intersection Cardinality (SI-CA) computes the intersection cardinality of two parties’ sets, which has many important and practical applications such as data mining and data analysis. However, in the face of big data sets, it is difficult for two parties to execute the SI-CA protocol repeatedly. In order to reduce the execution pressure, a Private Set Intersection Cardinality (PSI-CA) protocol based on a quantum homomorphic encryption scheme for the Toffoli gate is proposed. Two parties encode their private sets into two quantum sequences and encrypt their sequences by way of a quantum homomorphic encryption scheme. After receiving the encrypted results, the semi-honest third party (TP) can determine the equality of two quantum sequences with the Toffoli gate and decrypted keys. The simulation of the quantum homomorphic encryption scheme for the Toffoli gate on two quantum bits is given by the IBM Quantum Experience platform. The simulation results show that the scheme can also realize the corresponding function on two quantum sequences.
Enhanced Efficiency at Maximum Power in a Fock–Darwin Model Quantum Dot Engine
Authors: Peña Francisco J. , Myers Nathan M. , Órdenes Daniel , Albarrán-Arriagada Francisco , Vargas Patricio
Published: March 2023

We study the performance of an endoreversible magnetic Otto cycle with a working substance composed of a single quantum dot described using the well-known Fock–Darwin model. We find that tuning the intensity of the parabolic trap (geometrical confinement) impacts the proposed cycle’s performance, quantified by the power, work, efficiency, and parameter region where the cycle operates as an engine. We demonstrate that a parameter region exists where the efficiency at maximum output power exceeds the Curzon–Ahlborn efficiency, the efficiency at maximum power achieved by a classical working substance.
p-GaN Selective Passivation via H Ion Implantation to Obtain a p-GaN Gate Normally off AlGaN/GaN HEMT
Authors: Ding Xiaoyu , Yuan Xu , Ju Tao , Yu Guohao , Zhang Bingliang , Du Zhongkai , Zeng Zhongming , Zhang Baoshun , Zhang Xinping
Published: March 2023

A dependable and robust technique for nanomachining is ion implantation. In this work, hydrogen (H) ion implantation was used, for the first time, to passivate p-GaN, except for the gate area, in order to create a normally off p-GaN/AlGaN/GaN high-electron-mobility transistor (HEMT). Ion implantation passivation reduces H ion diffusion in p-GaN, allowing it to withstand temperatures above 350 °C. Through experiments and analyses, the H ion implantation energy and dosage required to passivate p-GaN, by generating Mg-H neutral complexes, were determined to be 20 keV and 1.5 × 1013 cm−2, respectively. After conducting annealing procedures at various temperatures, we discovered that 400 °C was the ideal temperature to effectively obtain a normally off p-GaN HEMT. A threshold voltage of 0.8 V was achievable. The p-GaN HEMT also had a breakdown voltage of 642 V at a gate voltage of 0 V, maximum transconductance of 57.7 mS/mm, an on/off current ratio of 108, an on-resistance of 8.4 mm, and a maximum drain current of 240.0 mA/mm at a gate voltage of 6 V after being annealed at 400 °C.