bluuebunny/crossref_metadata_2025 huggingface dataset:
Upregulated Glycolysis Correlates With Clinical and Transcriptomic Significances in Head and Neck Squamous Cell Carcinoma
Authors: Takahashi Hideyuki , Kawabata-Iwakawa Reika , Ida Shota , Mito Ikko , Tada Hiroe , Chikamatsu Kazuaki
Published: April 2021

Altered metabolism is an emerging hallmark of cancer. Cancer cells preferentially utilize glycolysis for energy production, termed “aerobic glycolysis.” In this study, we performed a comprehensive analysis of the glycolysis status in the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) using data from The Cancer Genome Atlas database. We first divided 520 patients with HNSCC into two groups based on the mRNA expression of 16 glycolysis-related genes. The glycolysis-high signature positively correlated with human papillomavirus-negative tumor type, advanced T factor, and unfavorable prognosis. The gene set enrichment analysis revealed upregulation of several pathways, including interferon-alpha response, myc targets, hypoxia, epithelial-mesenchymal transition, transforming growth factor-β signaling, and interleukin 6-Janus kinase-signal transducer and activator of transcription 3 signaling, in the glycolysis-high group. Immune cell enrichment analysis revealed decreased infiltration of T cells, dendritic cells, and B cells in the glycolysis-high group, suggesting impaired tumor antigen presentation, T cell activation, and antibody production in TME. Moreover, the expression of TGFB1, CD274, and PDCD1LG2, which facilitate immunosuppression in the TME, was upregulated in the glycolysis-high group. Collectively, these findings suggest the potential of glycolysis monitoring as a biomarker for tumor progression and immunosuppression in the TME of HNSCC.
Successful Operation Following Neoadjuvant Immunotherapy Combined with Chemotherapy for Right Aortic Arch with Esophageal Cancer: A Case Report
Authors: Luo Zhilin , Wang Tianhu , Li Dong
Published: April 2021

Background Right aortic arch (AAA) with esophageal cancer is a kind of rare case. Tumor shrinkage after neoadjuvant immunotherapy combined with chemotherapy and subsequently successful excision of the esophageal tumor under minimally invasive surgery are reported for this case in this paper.Case presentation The patient was a 50-year-old man who was diagnosed with AAA and esophageal cancer with a clinical stage of c-T3N1M0, stage III. Because Computed tomography(CT) indicated a larger volume of the tumor with signs of outward invasion, along with vascular malformations, neoadjuvant immunotherapy combined with neoadjuvant chemotherapy was given. After 3 cycles of neoadjuvant therapy, this patient achieved a fully clinical symptom remission, and re-examination result of chest CT showed tumor shrinkage, so a minimally invasive surgery was provided to remove the tumor. Following the surgery, immunotherapy and chemotherapy were continued.Conclusion For locally advanced esophageal cancer with vascular malformations, neoadjuvant therapy is a good treatment option. If achieving downstaging, the tumor would be well removed just with a minimally invasive surgery.
Interoperability Opportunities and Challenges in Linking mHealth applications and eRecord systems: Botswana as an Exemplar
Authors: Ndlovu Kagiso , Scott Richard E. , Mars Maurice
Published: April 2021

Background
Significant investments have been made towards the implementation of mHealth applications and eRecord systems globally. However, fragmentation of these technologies remains a big challenge, often unresolved in developing countries. In particular, evidence shows little consideration for linking mHealth applications and eRecord systems. Botswana is a typical developing country that has adopted mHealth applications, but the solutions are not interoperable with existing eRecord systems. This paper describes Botswana’s eRecord systems interoperability landscape and provides guidance for linking mHealth applications to eRecord systems, both for Botswana and for developing countries using Botswana as an exemplar.
Methods
A survey and interviews of health ICT workers and a review of the Botswana National eHealth Strategy were completed. Perceived interoperability benefits, opportunities and challenges were charted and analysed, and future guidance derived.
Results
Survey and interview responses showed the need for interoperable mHealth applications and eRecord systems within the health sector of Botswana and within the context of the National eHealth Strategy. However, the current Strategy does not address linking mHealth applications to eRecord systems. Across Botswana’s health sectors, global interoperability standards and Application Programming Interfaces are widely used, with some level of interoperability within, but not between, public and private facilities. Further, a mix of open source and commercial eRecord systems utilising SQL database systems and similar data formats are supported. Challenges for linking mHealth applications and eRecord systems in Botswana were identified and categorised into themes which led to development of guidance to enhance the National eHealth Strategy.
Conclusion
Interoperability between mHealth applications and eRecord systems is needed and is feasible. Opportunities and challenges for linking mHealth applications to eRecord systems were identified, and future guidance stemming from this insight presented. Findings will aid Botswana, and other developing countries, in resolving the pervasive disconnect between mHealth applications and eRecord systems.
Differential Occurrence of Epicuticular wax and its Role in Leaf Tissues of Three Edible Aroids Hails from North Eastern Hill Region of India
Authors: Pieniazek Facundo , Dasgupta Madhumita , Messina Valeria , Sahoo Manas Ranjan
Published: April 2021

Localization of epicuticular wax (EW) content in leaf tissues and its interaction on leaf protective mechanisms of three edible aroids, Alocasia, Colocasia and Xanthosoma were assessed. Scanning electron microscopy depicted the occurrence of EW in leaf tissues which was higher in Colocasia (10.61 mg dm-2) and Xanthosoma (11.36 mg dm-2) than in Alocasia (1.36 mg dm-2). The result highlighted the interface of EW between the leaves and its internal and external environments. EW acted as a protecting barrier against deleterious solar radiation in term of sun protecting factor (SPF). Occurrence of EW also effectively managed leaf pigmentation, moisture retention, cellular membrane integrity against the invaders. Colocasia exhibited superhydrophobic properties with higher static contact angle (CA) >150o than hydrophobic Xanthosoma and Alocasia with CA ranged between 99.0o to 128.7o. Colocasia EW highly influenced the qualitative and protective mechanisms of leaf. Aroids are the cheapest sources of edible EW among the terrestrial plants could be used in food, agricultural and industrial applications.
A Low Complexity STPAP Algorithm based on Alternating Polarization Sensitive Array
Authors: Sha Shuang , Lyu Tingting , Zhang Hao , Gulliver T. Aaron
Published: April 2021

Background: Space-time adaptive processing (STAP) has been widely used in the fields of communication, radar, and navigation anti-jamming. However, the traditional scalar array used by STAP has certain limitations，because it can only obtain spatial information. In order to further improve the performance of the space-time domain joint filtering technology, this paper replaces the traditional scalar array with an alternating polarization sensitive array (APSA). Compared with the dual polarization sensitive array (DPSA), it can not only obtain the polarization information of the signal, but also reduce the computational complexity of the algorithm. Methods: Using the polarization information of the signals, this paper realizes an alternate polarization sensitive array space-time-polarization adaptive processing algorithm (APSA-STPAP) based on the linear variance minimum criterion (LCMV). Different from the traditional LCMV criterion, this paper takes the space-time polarization joint steering vector of the desired signal and the interference signal as the constraint matrix, and uses the "1 condition" and "zero condition" as the constraint conditions to effectively suppress the interference signal and enhance the expectation signal. Results: The simulation results show that: (1) APSA-STPAP algorithm can achieve the same filtering effect as DPSA-STPAP algorithm. From the perspective of the spatial domain, time domain and polarization domain, it can form null in the direction of interference, effectively suppress the interference signal, and realize space-time-polarization adaptive processing. (2) Under the same conditions, APSA-STPAP algorithm can achieve the same filtering effect as DPSA-STPAP algorithm. there is a big difference between the two algorithms, APSA-STPAP algorithm can effectively reduce the amount of computation. Moreover, the dipole of alternating polarization sensitive array is halved, which reduces the coupling effect between electric dipoles, and is conducive to engineering implementation. (3) APSA-STPAP algorithm can maintain good anti-interference performance even when the electric dipole and anti-jamming degree of freedom are reduced by half, and its anti-jamming performance is similar to that of polarization sensitive array. The output SINR of DPSA-STPAP algorithm is about 3dB higher than that of APSA-STPAP algorithm. There is little difference between the anti- interference performance of APSA and DPSA.
A Case-Control Study on Blood Lipid Profile in Patients with COVID-19
Authors: Changaripour Shahab , Sarvazad Hosna , Barghi Maryam , Sajadi Elham , Sadeghian Mahdi Hashempour , Eskandari-Roozbahani Narges
Published: April 2021

Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.
Preparation of Ti/Al composite plates by differential temperature rolling with induction heating
Authors: Yu Chao , He zhibin , Lv Qiang , Yu Jirui , Xiao Hong
Published: April 2021

In the current study, we proposed a method of differential temperature rolling with electromagnetic induction heating to prepare Ti/Al composite plates in a protective atmosphere to realize the homogeneous deformation of Ti/Al bonding rolling and improve the interfacial bonding strength of the composite plates. The temperature field required for homogeneous deformation rolling of titanium and aluminum was constructed through finite element simulation by adjusting the parameters of electromagnetic induction heating, which made a temperature difference of about 632°C between titanium and aluminum, and the temperature of each plate was relatively uniform. The induction heating experiment was designed based on the finite element simulation, and the accuracy of the simulation results was verified by the experiment. The effects of rolling temperature and reduction rate of homogeneous deformation and bonding strength of Ti/Al composite plates were studied by rolling experiments. When the heating temperature of the Ti plate is 750–850°C, and the reduction rate is 30%-48%, with the increase of rolling temperature and reduction rate of titanium, the reduction rate of Ti plate and Al plate gradually tend to be the same. When the temperature of titanium plate and aluminum plate is 850°C and 188°C, respectively, with the rolling reduction rate of 48%, the deformation rate of Ti plate and Al plate is 46.8% and 48.6%, respectively, and the bonding strength of the composite plate reaches 77MPa.
Levels of serum VEGF-C/D and CXCL-12 are related to the severity of proteinuria in diabetic nephropathy
Authors: Tian Qingshan , Yang Zhichao , Li Lianfei , Kong Yun , Zhu Hongwen , Yang Yiheng , Wu Hao , Zheng Zhenzhong
Published: April 2021

Objective

To investigate the relationship between serum levels of lymphangiogenic factors and type 2 diabetic nephropathy and to evaluate the role of lymphangiogenesis in diabetic nephropathy.
Methods

The patients were divided into a normal albuminuria group (UmAlb < 30 mg/24 h, n = 30), microalbuminuria group (UmAlb 30–300 mg/24 h, n = 30) and massive albuminuria group (UmAlb > 300 mg/24 h, n = 30), and 30 healthy individuals were enrolled as the healthy control group (n = 30). Levels of serum vascular endothelial growth factor-C (VEGF-C), vascular endothelial growth factor-D (VEGF-D) and chemokine ligand 12 (CXCL-12) were quantified by enzyme-linked immunosorbent assay kits.
Results

The serum levels of VEGF-C,VEGF-D and CXCL-12 were significantly increased in all type 2 diabetic nephropathy groups. The correlation analysis showed that serum levels of VEGF-C, VEGF-D and CXCL-12 were positively correlated with serum creatinine and urinary microalbumin, and negatively correlated with estimated glomerular filtration rate. For discriminating the DN patients in the massive albuminuria group, microalbuminuria group and normal albuminuria group, the areas under the receiver operating characteristic curve (AUC-ROCs) for VEGF-C were 0.668 (95%CI: 0.531–0.805), 0.799 (95%CI: 0.678–0.920), and 0.850 (95%CI: 0.756–0.944); when the cutoff values were 152.40, 196.05 and 214.60 pg/ml, and the sensitivity was 93.3%, 96.7% and 100.0%, the specificity was 40.0%, 50.0% and 56.7%, respectively.
Conclusion

Serum VEGF-C,VEGF-D and CXCL-12 levels gradually increased in diabetic nephropathy, which has high value for the early diagnosis and evaluation of disease severity in diabetic nephropathy. These findings suggest that serum VEGF-C,VEGF-D and CXCL-12 levels may be a useful surrogate marker of clinical outcome in DN.
Autophagy Regulates the Effects of Adipose-derived Stem Cells Exosomes on Lipopolysaccharide-induced Pulmonary Microvascular Barrier Damage
Authors: Li Chichi , Li Liqun , Wang Min , Wang Wangjia , Li Yuping , Zhang Dan
Published: April 2021

Background: Exosomes have been recognized as being more effective than direct stem cell differentiation into functional target cells for protecting against tissue injury and promoting tissue repair. Our previous study demonstrated the protective effect of adipose-derived stem cells (ADSCs) on lipopolysaccharide (LPS)-induced acute lung injury and the effect of autophagy on ADSC functions, but the role of ADSC-derived exosomes (ADSC-Exos) and autophagy-mediated regulation of ADSC-Exos in LPS-induced pulmonary microvascular barrier damage remain unclear. Methods: LPS-induced pulmonary microvascular barrier injury was detected after ADSC-Exos pretreatment. Effects of autophagy on the function and bioactive miRNAs components of ADSC-Exos were assessed after inhibiting the cells autophagy in advance. Results: ADSC-Exo culture resulted in significant alleviation of LPS-induced microvascular barrier injury. The inhibition of autophagy markedly weakened the therapeutic effect of ADSC-Exos. In addition, autophagy inhibition changed the expression levels of the five specific miRNAs in exosomes; interleukin-1β（IL-1β）preconditioning promoted the expression of miR(miRNA)-21a but lowered the expressions of let-7-a-1, miR-143 and miR-145a, and did not affect the expression of miR-451a. Autophagy inhibition, however, has prohibited the expressions of all these miRNAs under IL-1β preconditioning. Conclusion: Our results indicate that ADSC-Exos protect against LPS-induced pulmonary microvascular barrier damage. Autophagy is a positive mediator of exosome function at least partly through controlling the expression of bioactive miRNAs in exosomes.
ALDOB Promotes Neuroblastoma Metastasis by Affecting EMT Pathway and is a Potential Prognostic Factor
Authors: Hu Xiaoxiao , Gu Yaoyao , Chen Kai , Dai Haipeng , Huang Jie , Wu Z , Wu Yeming , Li Zhongrong
Published: April 2021

Background： Aldolase B (ALDOB) is a member of the aldolase family, which is the fourth enzyme in glycolysis process. In recent years, the non-enzymatic effects of some glycolytic enzymes have been reported to promote the formation of several human tumors, but the non-enzymatic action of ALDOB in neuroblastoma(NB) remains unclear. This study aims to explore the non-enzymatic effect of ALDOB in neuroblastoma.Methods： We used immunohistochemistry to examine 63 patients tissue microarray samples and 3 pairs of lymph node metastases and the primary tissue samples, and evaluated the relationship between ALDOB expression level and clinical characteristics. We then analyzed the public datasets of NB based on microarray to verify the immunohistochemistry results. In addition, we conducted in vitro experiments on SK-N-BE(2) and SH-SY5Y cell lines to explore the molecular mechanism.Results： Immunohistochemistry indicated ALDOB is significantly associated with INSS stage and tumor metastasis in NB, public dataset analysis showed ALDOB is related to NB patient survival remarkably. In vitro experiments displayed silencing ALDOB may inhibit the cell migration by epithelial-mesenchymal transition (EMT) pathway.Conclusions： Our finding demonstrated that ALDOB can affect the metastasis of NB by EMT pathway and may be a potential target for neuroblastoma therapy in the future.
The Impact of Intermittent Preventive Treatment with Sulfamethoxazole Pyrimethamine on Pregnant Women and Newborns at Bon Samaritain Hospital in N'Djamena, Chad.
Authors: Neguemadji Ngaba Ngardig , Askemdet Obélix , Hange Namrata , Pormento Maria Kezia Lourdes Ligsay , Dogar Zeryab Ghous , Chaouche Amel Braham , Somagutta Manoj Kumar Reddy
Published: April 2021

Background: The Chadian government established a program of free intermittent preventive treatment withsulfadoxine-pyrimethamine (IPTp-SP) for pregnant women. This program estimated the impact of IPTp-SP onthe malarial prevalence among women and newborn children, a study was planned for pregnant women whoconsulted in the Bon samaritain hospital in NDja mena, Chad.Methods: This 14 month study was conducted on 149 pregnant women. They were followed until delivery foroutcomes such as malaria attacks, anemia and placental malaria, low birth weight and prematurity in newborns.Data was collected with the help of a pretested questionnaire. Data was analysed with SPSS and R studio, Oddsrisk was calculated.Results: The mean age of the study participants was 25.8 ś 6.2 years with 72.5% under the age of 20 years,and half were housewives with a secondary school education. More than half of the pregnant women (84,56.3%) never used insecticide-treated mosquito nets. Among the 149 study participants, (64, 42,95%) received3 doses of IPTp-SP, while 31( 20.8%) did not receive any dose of IPTp-SP. Only 30% (45) of the total 149participants reported to be malaria positive; while 28.9% (43) were diagnosed with placental malaria. Of the43 placenta malaria cases, 21(48.83%) had not received SP. Most of the lower birth weight babies with weight< 2500g (40,81.64%) were reported in pregnant mothers who have reported administration of one or no doseof SP. Out of 31 pregnant women, 21 (67.7%) without IPTp-SP had reported at least one attack of malariaduring their pregnancy compared to 22 women out of 118(18.7%) of those who had at least one dose ofSulfamethoxazole pyrimethamine (p = 0.001 ). Out of 31 pregnant women who have not received IPTp-SP,26 women (83.9%) reported anaemiaw ith Hb <10.5g/dl while 17 (65.4%) with severeanemia Hb <8g/dl .Conclusion: The maternal rate of attack of malaria, placenta infestation, maternal anemia,and low birth weightbabies decrease considerably with administration of three or more doses of s ulfadoxine-pyrimethamine.
Soluble P-selectin and Correlation with Prothrombin Fragment 1+2 in Myeloid Malignancies in Cipto Mangunkusumo General Hospital
Authors: Sukrisman Lugyanti
Published: April 2021

Background
Patients with hematological malignancies carry increased risk of cancer-associated thrombosis and adhesion molecule plays an important role in the mechanism of thrombus formation. The study aimed to evaluate the soluble P-selectin and prothrombin fragment 1 + 2 (F1 + 2) and to determine the correlation of sP-selectin with leukocyte count and F1 + 2 levels in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients.
Methods
A cross-sectional study of newly diagnosed AML and CML patients, aged 18 years or older. The exclusion criteria were pregnancy, severe infection, immobilization for at least 3 days or during intensive chemotherapy. Controls were healthy people, without anticoagulant and/or antiplatelet medication. Complete blood count was measured by ABX Micros 60®, and sP-selectin and F1 + 2 levels were determined using Behring ELISA Processor-III® and Behring Enzygnost F1 + 2.
Results
A total of 55 subjects, consisted of 25 AML and 13 CML patients and 17 controls. Soluble P-selectin was significantly elevated in AML patients compared to CML patients (median 0.14 vs 0.25 ng/mL, p = 0.001). Levels of F1 + 2 in AML (median 519.03 pmol/L) and CML patients (median 370.16 pmol/L) were significantly increased compared to controls (p < 0.001 and p = 0.043). Soluble P-selectin were significantly correlated to leukocyte count (R = 0.437; p = 0.029) and F1 + 2 (R = 0.436; p = 0.029) in AML, but not in CML patients.
Conclusions
AML and CML patients had increased expression of sP-selectin and coagulation activation. While CML patients had higher sP-selectin, AML patients had the highest state of hypercoagulability. Soluble P-selectin was correlated with leukocyte count and F1 + 2 in AML patients.
Highly efficient maximum-likelihood identification methods for bilinear systems with colored noises
Authors: Li Meihang , Liu Ximei , Fan Yamin
Published: April 2021

As a special class of nonlinear systems, bilinear systems can naturally describe many industrial production process. This paper mainly discussed the highly efficient iterative identification methods for bilinear systems with autoregressive moving average noise. Firstly, the input-output representation of the bilinear systems is derived through eliminating the unknown state variables in the model. Then based on the maximum-likelihood principle and the negative gradient search principle, a maximum-likelihood gradient-based iterative (ML-GI) algorithm is proposed to identify the parameters of the bilinear systems with colored noises. For further improving the computational efficiency, the original identification model is divided into three sub-identification models with smaller dimensions and fewer parameters, and a hierarchical maximum-likelihood gradient-based iterative (H-ML-GI) algorithm is derived by using the hierarchical identification principle. A gradient-based iterative (GI) algorithm is given for comparison. Finally, the algorithms are verified by a simulation example. The simulation results show that the proposed algorithms are effective for identifying bilinear systems with colored noises and the H-ML-GI algorithm has a higher computational efficiency and a faster convergence rate than the ML-GI algorithm and the GI algorithm.
Gender, health and ageing in Fiji: a mixed methods analysis
Authors: Dodd Rebecca , Shanthosh Janani , Lung Thomas , Robaigau Aporosa , Perman Mai Ling , Rafai Eric , Poulos Roslyn , Zwi Anthony B. , John Renu , Palagyi Anna
Published: April 2021

Background

Women are disadvantaged by ageing: older women are more likely than older men to suffer from ill-health, have less access to health care and suffer discrimination within the health care system. Globally, there is a dearth of health research on gender and ageing with substantial knowledge gaps in low and middle-income country contexts. Part of a wider investigation on health and ageing in Fiji, our objective was to identify and describe gendered differences in healthy ageing in this Pacific Island context which we believe to be the first such study in the Pacific region.
Methods

Applying a health systems lens, we used a mixed-methods approach, encompassing analysis of cause of death data; focus group discussion to gather community and family attitudes to health services; and policy analysis, and then used data triangulation techniques to draw out key themes and insights.
Results

We found that gender affects health outcomes among older persons, attitudes towards and experience of healthy ageing, and an older person’s access to and use of health services. We also found that while Fiji’s policy response to ageing has recognised the importance of gender, to-date there has been limited action to address gender differences. Gender (as oppose to sex differences) has direct and indirect implications for the health of older Fijians, while gendered inequalities and patriarchal norms appear to affect both men and women’s experience of ageing and the health system response. Further, gender and age discrimination may be intersecting, intensifying their separate effects.
Conclusion

This study demonstrates the feasibility and importance of applying a gender lens to the study of healthy ageing. Our findings from Fiji are likely to be relevant to other Pacific island countries, and beyond; and, the data triangulation methodology may be considered as an efficient and insightful way to examine gendered responses to healthy ageing elsewhere.
he omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial
Authors: Abdolahi Mina , Karimi Elmira , Sarraf Payam , Tafakhori Abbas , Siri Goli , Sedighiyan Mohsen , Asanjarani Behzad , Djalali Mahmoud , Badeli Mostafa , Abdollahi Hamed , Yoosefi Niyoosha , Abdullah Hakima , Shayegan Amir
Published: April 2021

Objective
The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine.
Results
In this study, 80 patients were randomly divided in to 4 groups to receive for 2 months. Both serum levels and gene expression of VCAM showed remarkable decreases after single W-3 and after combined W-3 and nanocurcumin interventions. However, a borderline significant change and no remarkable change were observed after single nanocurcumin supplementation and in control group, respectively. While a significant difference between study groups in VCAM concentrations existed, there was no meaningful difference in VCAM gene expression among groups. It appears that the W-3 and combined W-3 and nanocurcumin can relieve VCAM serum level and its gene expression in patients with episodic migraine. Moreover, the combination of W-3 with nanocurcumin might cause more significant declines in VCAM level in the serum of migraine patients than when W-3 is administered alone.
Remote Patient Monitoring and classifying Using the Internet of Things Platform Combined with Cloud Computing
Authors: Iranpak Somayeh , Shahbahrami Asadollah , Shakeri Hassan
Published: April 2021

Patients' health and providing an optimal and appropriate solution have recently been considered by many researchers. With the advent of technologies such as cloud computing and 5G network, information can be exchanged faster and more securely. Using cloud computing in this process can significantly improve the monitoring of certain patients. Therefore, providing a favorable method in the medical industry and computer science to monitor the status of patients using connected sensors is very important. Thus, due to its optimal efficiency, speed, and accuracy of data processing and classification, the use of cloud computing to process the data collected from remote patient sensors and the Internet of Things (IoT) platform has been suggested. In this paper, a prioritization system is used to prioritize sensitive information in IoT, and in cloud computing, LSTM deep neural network is used to classify and monitor patients' condition remotely, which can be considered as an important innovative aspect of this paper. Sensor data in the IoT platform is sent to the cloud with the help of the 5th generation Internet. The core of cloud computing uses the LSTM deep neural network algorithm. Through simulating the proposed method and comparing the obtained results with other methods, it was observed that the accuracy of the proposed method has been improved significantly compared to other methods.
Copepod Production in Warm, Oil Polluted Environment: A Laboratory Investigation of Temora stylifera (Dana, 1849) Adapted to the Gulf of Guinea
Authors: Asiedu Delove , Acheampong Emmanuel , Asare Noble
Published: April 2021

Recent studies suggests that sea surface warming, evidently caused by greenhouse gas emissions, magnifies the toxicity of petroleum hydrocarbons on marine copepods. We assessed this understanding using Temora stylifera, a calanoid copepod common in the Atlantic Ocean and its surrounding waters, as a case study. The copepod was exposed to moderate (0.2 μg.l-1) and high levels (2.0 μg.l-1) of pyrene under three warming scenarios: (i) a no warming control at 28 °C, the surface temperature of the Gulf of Guinea during stable hydrographic period, (ii) moderate warming (+2 °C) and (iii) severe warming (+4 °C) above the control. Food ingestion rate of the copepod increased with warming without significant effect from the pollutant. Feacal pellet production rate (FP) increased by about 86% when the animal was exposed to moderate warming and pyrene at the same time, signifying reduced assimilation of food ingested in these conditions. Lowest FP (3.5 ± 1.1 copepod-1.day-1) indicating increased food assimilation occurred when the stressors were presented either alone or together. Egg production rate and efficiency of the copepod were impacted by only warming, decreasing by ≈60% under both warming scenarios, consistent with previous observations. Mortality rate increased by ≈ 40 % when pyrene pollution was elevated from nought to the highest level. It did not change significantly with temperature, suggesting warming did not exacerbate the lethal effect of pyrene to T. stylifera. These results are contrary to observations on other copepods and highlight the unique responses of Temora to sea surface warming and petroleum pollution.
Development a Nomogram for Predicting Intrahepatic Cholangiocarcinoma in Patients with Biliary Calculi after Surgery
Authors: Chen Junyu , Zhou Wangxin , Zhu Xiandong , Tang Yinhe , Wang Haibiao , Wu Lijun , Li Hong
Published: April 2021

Objective: To find out the risk factors of intrahepatic cholangiocarcinoma ( ICC ) in patients who underwent biliary surgery for biliary calculi, and to develop a nomogram to better predict the occurrence of ICC.Methods: Data were collected and analyzed retrospectively from 322 patients who underwent biliary tract surgery for biliary calculi in the First Affiliated Hospital of Wenzhou Medical University from January 2000 to December 2017.Of these patients, 58 patients had biliary calculi complicated with ICC while the other 294 patients had simple biliary calculi. Both univariate and multivariate analyses were performed to find out the risk factors related to ICC, and a nomogram was further developed based on the results of multivariate analysis.Results: The univariate analysis showed that there were significant differences in age composition (≤ 60 years old, > 60 years old), liver cirrhosis, stone history and previous hepatitis B infection (HBsAg- and HBcAb+) between the two groups. Logistic regression analysis indicated that liver cirrhosis (OR=2.011, 95%CI=1.023-3.952), stone history (OR=1.086, 95%CI=1.051-1.112) and age > 60 (OR=2.045, 95%CI=1.059-3.948) were the risk factors of ICC, while previous hepatitis B infection (HBsAg- and HBcAb+) (OR=0.461, 95%CI=0.215-0.989) was the protective factor. After drawing a nomogram, it was found that the area under the curve was 0.753 (95% CI=0.686-0.818), and the best cutoff value obtained by Youden index was 0.164. Moreover, the calibration curve indicated the best consistency between the predicted probability and the actual probability.Conclusion: We developed a nomogram, which was novel and accurate, to predict the risk of ICC in patients received biliary surgery for biliary calculi. This nomogram is of certain significance for the early detection of ICC.
A Microscopic and Metabolomic Description of Stip-affected Tissue in New Mexico Pod-type Pepper
Authors: Fulton James C. , Holguin Francisco O. , Steiner Robert L. , Uchanski Mark E.
Published: April 2021

Stip is a physiological disorder that affects certain pepper (Capsicum annuum) cultivars, most notably bell-pod types. It has been attributed in the literature to nutrient imbalances, temperature extremes, and/or other environmental stressors. Symptoms present as brown, black, and yellow ovoid-shaped necrotic lesions ≈0.5 to 1.2 cm long by 0.5 cm wide. Between 2014 and 2015, symptomatic and asymptomatic pods were harvested from 15 commercial farms in southern New Mexico. Fluorescent microscopy comparisons of harvested symptomatic tissue revealed a unique fluorescent signature and the absence of chlorophyll. A new spectral peak centered around 560 nm was observed in symptomatic tissue. High-performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC-MS) analyses of these tissues detected significant differences in 13 metabolites, of which several have been associated with fruit maturation and/or senescence. This report represents the first combination of a detailed microscopic description and metabolite profile of field-grown symptomatic plants with this disorder.
The Physiology and Mythology of the "Domestic" and the "Alien": The Model of the Vampire in Serbian Traditional Culture and Popular Culture
Authors: Žikić Bojan
Published: April 2021

The vampire in Serbian traditional culture and the vampire in popular culture are two different beings. The former is virtually identical to people in his community, does not undergo a change of character after death, and getting rid of him is the task of the whole community. He is linked to his socio-cultural environment and his existence is not linked to physiological needs and possibilities, but is circumscribed by the ability of the living members of his community to oppose him. The latter is a distinct being with supernatural abilities, whose character changes after death in the sense that he becomes a predator, a physical and ontological threat to man, and can be opposed by those who know his characteristics and weaknesses. He is not territorially restricted in his actions, but from the author's point of view he is always depicted as an interloper. He is a simulation of man insofar as he has to sustain himself in the afterlife by feeding himself, and has the ability to reproduce, i.e. to produce new beings of his kind. They have the following in common: 1) they continue to exist after death in their own physical body; 2) they are representations of the revived dead body of a concrete person, whose behavior has in the case of both models been altered precisely to the extent that this alteration can be ascribed to the notion of physical existence after death. The given malevolence, as the fundamental characteristic of the vampire's relationship to people, in both cases stems more from the meaning of the existence of these models than from a concept of an afterlife, that is, from the need to resolve the internal problems of the traditional community conceived as the local environment, and the need for self-determination towards that which is different, alien and foreign in societies of the new type, based on transcending socio-cultural locality and establishing global cultural communication.
The Oedipus Tale Type in Azerbaijani: Folklore and its Socio-Psychological Semantics
Authors: Garayev Safa
Published: April 2021

In this article, I analyze tales collected from Azerbaijani territories from a psycho-semantic perspective, specifically pertaining to the Oedipus tale type (AT: 931, 933). The incest taboo, a common theme in Azerbaijani society, is discouraged in these tales through symbolic behaviors. In these tales, which were collected in different Azerbaijani territories at different times, the transgression of the taboo of incest firstly happens between sisters and brothers, later between mothers and sons. When we approach the fairy tale plots presented in the context of the Oedipus complex, it becomes clear that these fairy tales are also organized on the basis of the son’s point of view. This is evident in the tales because of their descriptions of the father—a common character in the Oedipus tale type—as the culprit of all anti-social and unethical problems. In the texts I present, the heroes of the tales generally derive from the disruption of the incest taboo between the sister and the brother, who has been left to die. I argue that the baby born as a result of dismantling the incest taboo—being removed from the chain (or from the family environment) of the social relations by the parents to be left to die and later living and not recognizing his mother—is portrayed as the main fact in the explanation of the events’ semantics.
HYPOMAGNESEMIA AND PROLONGED HOSPITAL STAY: A CASE REPORT AND LITERATURE REVIEW
Authors:   Department of Internal Medicine at Al Jahra Hospital, Jahra and Kuwait., Al-Shami Ahmad , Aljabri Jabri ,   Department of Internal Medicine at Al Jahra Hospital, Jahra and Kuwait., Al-Bloushi Shahad ,   Department of Internal Medicine at Al Jahra Hospital, Jahra and Kuwait.
Published: April 2021

Hypomagnesemia is a common finding in hospitalized patients mostly overlooked and rarely given as much attention as other electrolyte disturbances. This case report and literature review highlight how hypomagnesemia is common in patients who have a prolonged hospital stay. in addition, we highlight the multiple causes of hypomagnesemia and discuss them further with a literature review.
EXTRACTION OF NATURAL DYE FROM BUTEA MONOSPERMA (LAM.) TAUB. FLOWER DYEING COTTON - POLYESTER FABRIC
Authors:   Department of Botany, Merchant Science College, Gadha (Basna), Mehsana, Gujarat, India., Patel Parag , Patel Karan ,   Department of Botany, Merchant Science College, Gadha (Basna), Mehsana, Gujarat, India., Prajapati Chilka ,   Department of Botany, Merchant Science College, Gadha (Basna), Mehsana, Gujarat, India., Thakor Meghna ,   Department of Botany, Merchant Science College, Gadha (Basna), Mehsana, Gujarat, India., Raval Neha ,   Department of Botany, Merchant Science College, Gadha (Basna), Mehsana, Gujarat, India.
Published: April 2021

Natural dyes are emerging globally as eco-friendly synthetic colorant. Natural dyeing is process of applying coloring matter directly on fiber, yarn or fabric without any additives. Butea monosperma (Lam.)Taub. is one of most important ornamental plants mainly grow in forest and rich in orange pigments. In the present study, the dyeing pigments present in naturally drop flowers of Butea monosperma (Lam.) Taub. Extraction by using four different Mordant with aqueous extraction method and one Ethno botanical local method on cotton-polyester mix fabric. The result revealed that, different color like light yellow, orange, brown, cream etc. were obtained from the dye when subjected to Mordant. The crud flower petals dye after further purification and refining has tremendous scope as medicine and also serve a coloring material in soft drink and other food product like jam, chow main, noodles, sausage etc. Natural dye from the flower of Butea monosperma (Lam.) Taub. In the field of textile, food item and pharmaceutical industry.
METABOLOENDOCRINE CROSS SECTIONAL STUDY ON THE RELATION BETWEEN MIGRAINE, HYPOTHYROIDISM AND OBESITY IN NORTHERN AND EASTERN REGION, KINGDOM OF SAUDI ARABIA
Authors: Abdulhadi Abdullah Alabbad Hana , Sadiq Abdulazim Almumtin Zahra , Abdallah Moursi Soha
Published: April 2021

Objectives: to determine the relation between Migraine, Hypothyroidism and Obesity in adult to be more aware about the factors which lead to Migraine and how to control them also to collect data for further investigation and suggest methods of control or minimize of its recurrence. Methods: surveillance cross sectional study, data were collected from 15th of November 2020 till 28th of February 2021. Study population Male and Females / adults /married or not married/with Obesity or Hypothyroidism or both and suffering from Migraine in Northern and Eastern region, Kingdom of Saudi Arabia, using questionnaires, statistical analysis was done by SPSS 22. Results: 188 responses to the questioner. The study finding showed that the range of participant mostly age between (20-30 y) with (63.3% ) and(41-50y) , (31-40 y) as (16.5%) and (14.4%), As for gender and level of Education the study showed that (80.3%) were female and (19.7%) were male while (63.3%) Bachelor degree and (28.7%) high school. Factors that may lead to inducing attacks of migraine ,the results showed that (48.9%) were over weighted ( 106-120kg) followed by (23.9%) (105-96 kg), for sleeping habits(70.7%) sleeping less than 6 hours /day and (85.1%) using electronic devices on daily bases and (81.4%) were drinking (0.5-1L ) water /day . Regarding symptoms accompanied migraine the study found that (51.6 %) of participants suffering from frequent migraine followed by( 23.9%) once per day and (75%) showed that duration of attacks takes 10 hours per day followed by( 13.3%) of the partisans duration takes 12 hours per day which affect the life routine by(58%) and the severity of the headache (60.6%) as mild to(25.6%) moderate level of pain. Other Hormonal/Metabolic factors that may be related to inducing migraine as hypothyroidism which can lead to gaining weight , the results showed that (9.6%) suffering from hypothyroidism and (92.6%) not diseased but on the other hand (64.4%) dont know that there is a relation between hypothyroidism, gaining weight and migraine and they gain weight lately by (96.3%).For treatment used for migraine attacks the results showed that (62.2%) takes painkillers while (26.1%) depend on home remedy for treatments of migraine , and for the new method of treatment by using BOTOX injection (90.4%) didnt know about this way of treatment. Conclusion: migraine can be indicator or a sign of other conditions and sometimes patients did not pay attention to them keep taking painkillers without diagnosing the cause . Spreading the awareness among society about factors can cause migraine and medical conditions that also involved in repeating attacks can help in decreasing and controlling attacks of migraine .Health care providers should help in increasing the awareness of healthy life habits and how to control migraine attacks and new methods of treatments.
MIRNA 146 AND ITS ASSOCIATION WITH AUTOIMMUNE DSEASES
Authors:   Department of biochemistry and Molecular Biology, Faculty Of Pharmacy, Helwan University., A. Hassan Zeinab , A. Emara Ibrahim. ,   National Institute for Diabetes And Endocrinology., A. Badawi Sara ,   Biotechnology Unit, Central Administration of Biological and Innovative Products And Clinical Studies, Egyptian Drug Authority., M.A. Akabawy Ahmed ,   Department of biochemistry and Molecular Biology, Faculty Of Pharmacy, Helwan University.
Published: April 2021

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, through a complex regulatory network, the expression of more than 60% of human genes. MiRNAs are key regulators of the immune response that affect maturation, proliferation, differentiation, and activation of immune cells, as well as antibody secretion and release of inflammatory mediators. In this review, we generally discuss miRNAs, its types and its role in the regulation of the immune system and the autoimmune inflammatory process, focusing on the participation of miRNA-146 in the development of multiple sclerosis (MS), Rhumatoid arthritis and Type-I diabetes mellitus. Disruption of this regulation may lead to the development of various pathological conditions, including autoimmune inflammation. Special attention is given to the role of miRNA-146 in the autoimmune inflammation in multiple sclerosis, Rhumatoid arthritis and Type-I diabetes mellitus. This study concluded that, dysregulation of miR-146 and its target genes was one of the main causes for many autoimmune diseases our findings indicate a significant association of decreased miR-146 expression and the sustained immune imbalance in multiple sclerosis, Rhumatoid arthritis and Type-I diabetes mellitus.
PROPOSAL AND SUGGESTIONS FOR KICK STARTING ECONOMIC ACTIVITY POST COVID 19 & CREATING BALANCED DEVELOPMENT AND EMPLOYMENT OPPORTUNITIES ACROSS THE NATION& AVOIDINGLARGE SCALE MIGRATION OF LABOUR IN INDIA - A RESEARCH PAPER LINKING INFRASTRUCTURE& BALANCED ECONOMIC DEVELOPMENT
Authors:   Founder & Director: The Engineers Forum and Persona Skill Development Institute., Bandiwadekar Dinesh
Published: April 2021

THIS PAPER FOCUSSES ON how we should quickly utilise the highways and other infrastructure created for the economic growth of the nation post covid 19, and get a proper return on THE investment already DONE In these AREAS.IT ALSO EXAMINES WHETHER BEYOND A POINT, Does creation of an extensive HIGHWAY / infrastructure network drive the economy AND IF it createS LONG TERM EMPLOYMENT, or are there better ways of doing the same. Items that are discussed more specifically are as under: 1. Leveraging current /existing developmentin the form of infrastructureto kick start further growth on an all India basis. 2. Promoting decongestion of cities from a health perspective& reduce migration across India. 3. Creating location based tax benefits to spur development and create new demand.to overcome the economic slowdown ,by using the already well done highway infrastructure 4. Creation of a modified tax administration system based on PIN Codes and tracking infrastructure growth and returns through PIN codes. The paper takes the liberty of proposing multiple but closely related issues as listed above that should be possibly considered by the Government for further improvement and mainly swift improvement of our country.