bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinación del Modelo de Saturación de Agua Inicial basado en Curvas de Presión Capilar por Tipo de Roca
Authors:   Petróleos de Venezuela (PDVSA). Maracaibo, Venezuela, Márquez Eddymar , Aguilar César ,   Petróleos de Venezuela (PDVSA). Maracaibo, Venezuela, Perozo Américo ,   Facultad de Ingeniería, Universidad del Zulia, Venezuela
Published: August 2021

La saturación de agua inicial (Swi) a partir de registros está influenciada por el drenaje de fluidos de los pozos productores, generando subestimación del petróleo original en sitio (POES). Para restaurar las condiciones iniciales del yacimiento, es necesario utilizar pruebas de presión capilar (Pc) de drenaje, que determinan la distribución de Swi previa a cualquier producción de hidrocarburos. Esta investigación tuvo como objetivo determinar el modelo de Swi, basado en curvas de Pc por tipo de roca, para una mejor estimación del POES del yacimiento LUZ de la cuenca de Maracaibo. El procedimiento metodológico incluyó: recopilación de datos (registros y núcleos, con 15 muestras de Pc), descripción de tipos de roca, determinación del modelo de Swi, y estimación del POES. Entre los resultados, destacan: el modelo J-Leverett se ajustó mejor a las curvas de Pc del yacimiento para todos los tipos de roca; el POES estimado utilizando la saturación de agua (Sw) del modelo propuesto basado en presión capilar y la calculada usando registros, mostró un 19,8 % de discrepancia, evidenciando la importancia de un modelo robusto para incrementar la certidumbre en el cálculo de reservas.
Controlling Wheelchair Using Brain as Biosensor
Authors: V Chandana
Published: August 2021

This project discusses about wheel chair controlled by brain based on Brain–computer interfaces (BCI). BCI’s are systems that can bypass conventional channels of communication (i.e., muscles and thoughts) to provide direct communication and control between the human brain and physical devices by translating different patterns of brain activity into commands in real time. The intention of the project is to develop a robot that can assist the disabled people in their daily life to do some work independent of others. Here, we analyse the brain wave signals. Human brain consists of millions of interconnected neurons, the pattern of interaction between these neurons are represented as thoughts and emotional states. According to the human thoughts, this pattern will be changing which in turn produce different electrical waves. A muscle contraction will also generate a unique electrical signal. All these electrical waves are sensed by the brain wave sensor and different patterns are used for controlling a wheel chair.
Experimental Analysis & Optimization with Validation of Ball Valve Body of WCB Material
Authors: Dhanraj Agre Virbhadra
Published: August 2021

The ball valves are used in place of pipelines where the flow of fluid is needed. Ball valves have been mostly used for high temperature and high pressure valves which requires high quality products with confidentiality, reliability and durability. The ball has a bore or passage through the middle, so that when the port is in line with both ends of the valve, the flow of fluid will occur. When the valve is closed, the hole is perpendicular to the ends of the valve, and the flow is closed. The ball valve can revolve 90°, which has large size and weight, but it has not only an enormously more excellent confidentiality than other valves in the severely high temperature and high pressure environment When the ball valve is in closed condition the pressure exerted on the ball valve body due to that high pressure fatigue stresses and strain develop on the body of valve. Because of the high pressure and temperature on the ball valve body leakage of body take place which cause safety issue and ball valve failure. By this research stress strain analysis of ball valve body obtains and identifies the maximum and minimum stress and strain produced on the body of ball valve. The Max stress by parts was confirmed through thermal-structural coupled field analysis of major parts to evaluate safety. The objective of this research is to examine the effect of pressure and temperatures on valve components its analysis and optimization
Efektivitas functional communication training dalam meningkatkan perilaku meminta pada anak dengan autism spectrum disorder
Authors: Tedjawidjaja Detricia , Hartiani Fenny
Published: August 2021

The current study aims to examine the effectiveness of functional communication training to increase asking behavior by exchanging pictures for children with an autism spectrum disorder. The participant in this study is a 6-years old girl with a diagnosis of Autism Spectrum Disorder with Intellectual Impairment. This study uses a single-subject design consisting of A-B-A phases. Functional communication training is implemented using the most-to-least prompting technique which is divided into 8 sessions. The result depicts that 84% of participants increase their ability to perform requesting behavior by exchanging pictures of the trials given. Furthermore, after the implementation of functional communication training, there is an increase in the frequency of requesting behavior by exchanging pictures at post-test (average 74%) and at follow-up (average 82%). Implications of this study indicate the importance of considering the function of problem behavior in training the appropriate communicative responses for children with an autism spectrum disorder.
Leflunomide during pregnancy; a case report and review of the literature
Authors: Klaver Paul de , Geesink Carolien , Broen Jasper , Derijks Luc
Published: August 2021

Leflunomide is a prodrug for teruflunomide and used for rheumatic
diseases. Teriflunomide is considered to be teratogenic and should be
avoided in pregnancy. We describe a case of teriflunomide exposure up to
the third trimester of pregnancy. A healthy baby was delivered, despite
substantial drug exposure. Multiple washout procedures were required to
reduce teriflunomide concentrations below the safe target concentration
0.02 mg/L.
FINANCIAL LITERACY AND CONSUMER FINANCIAL STABILITY: ANY RELATIONSHIP WITH Macro-ECONOMIC STABILITY?
Authors: Matey Juabin
Published: August 2021

Despite efforts to deal with life’s economic issues on a daily basis, the majority of Ghanaians are financially vulnerable. This has made pursuing lifelong ambitions more difficult. Given these realities, it is reasonable to believe that financial literacy and consumer financial stability will be a successful strategy for promoting economic stability. Financial literacy is pivotal for making informed financial decisions at both the household and macroeconomic levels. A high human development index score indicates that persons who make up the country’s population are in good health. As a result, linking household decisions to broader policy outcomes becomes increasingly vital. This research aims to find a link between financial literacy and consumer financial stability as well as their relationship with macroeconomic stability. Financial literacy has a significant association with economic stability as measured by citizens’ welfare. This discovery has several ramifications for financial literacy initiatives. In addition, consumer financial wellness has an insignificant positive impact on national economic stability. Nonetheless, it demonstrates how a financially sound consumer can boost aggregate demand by spending more, impacting job creation and macroeconomic growth. The Probit-Regression Model facilitated data analysis using a participant population of 960 across eight studied regions in Ghana. This study believes that national governments should take the favourable correlations between financial literacy and consumer financial stability on the one hand, and national economic stability on the other, seriously. As a result, policy efforts should consider the relationship between microeconomic actions and macroeconomic outcomes since the former is observed to influence the latter.
Shared Decision Making
Authors: Ballamudi Apurupa , Chi John
Published: August 2021

Shared decision-making (SDM) is a process in which patients and providers work together to make medical decisions with a patient-centric focus, considering available evidence, treatment options, the patient’s values and goals, and risks and benefits. It is important for all providers to understand how to effectively use SDM in their interactions with patients to improve patients’ experiences throughout their healthcare journey. There are strategies to improve communication between patients and their providers, particularly when communicating quantitative data, risks and benefits, and treatment options. Decision aids (DAs) can help patients understand complex medical information and make an informed decision.

This review contains 9 figures, 4 tables and 45 references
Key words: Shared decision-making, decision-making, communication, risk and benefit, patient-centered, health literacy, quality of life, decision aids, option grid, pictographs.
Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report
Authors: Souaid Karim , Oulès Bénédicte , Sohier Pierre , Deschamps Lydia , Aractingi Sélim , Dupin Nicolas
Published: August 2021

Abstract is missing (Short communication)
Carpal Antelunar Dislocation and Fenton Syndrome: Extremely Rare Association
Authors: Yahyaoui Mounir
Published: August 2021

Carpal antelunar dislocations are much rarer than posterior dislocations. Their frequencies are between 3 and 6% of carpal perilunar dislocations. Out of 23 cases of carpal antelunar dislocations listed in the literature, there are only 11 trans-scapho antelunar dislocations. Carpal antelunar dislocation and Fenton syndrome are two exceptional entities in the literature. In the case of Fenton syndrome, the head of the capitatum is described with a rotation of 90 o to 180 o . The association of these two entities remains anecdotal (3 cases described). The anterior approach of carpal antelunar fracture-dislocation was recently honored. This approach offers the benefit of better control of associated intracarpal fractures. In our case, the fracture of the capitatum forced us to a dorsal approach. This approach allowed the reduction and osteosynthesis of the scaphoid satisfactorily. At 3 months, the patient has very good clinical and radiological results.
Shoulder Function Following Latarjet Procedure for Recurrent Anterior Shoulder Instability
Authors: Matsebula Lindiwe Fortunate
Published: August 2021

Introduction: Anterior shoulder dislocation and recurrent glenohumeral instability is very common in the young active population. It is usually caused by trauma, and often compounded by associated bony Bankart and Hill-Sachs lesions, which distort the anatomy. This causes instability and dysfunction of the joint and these can be addressed by, amongst others, a Latarjet surgical procedure. Hypothesis: We hypothesize that since the Latarjet procedure results in stability and good functional outcome, our results are expected to compare favourably to the rest of the published literature. Methods: A retrospective study of 31 patients treated with the Latarjet procedure at Helen Joseph hospital, Johannesburg South Africa was undertaken during the period of January 2005 to December 2013. The minimum follow up was 6 months. Stability was assessed looking at re-dislocation rate and the clinical functional outcome was measured using the Constant Score. Results: There were no shoulder re-dislocations and the mean Constant score was 85.35. 74% had a Constant Score above 80. 68% were pain free and 61% had normal activities of daily living while 68% had a full range of motion and 68% had full power. Conclusion: The Latarjet results in stability and good functional outcome. In our patient cohort, the Latarjet procedure provided reliable stability to the shoulder joint. Pain was alleviated, shoulder muscle power was preserved, range of shoulder motion was restored and patients did return to pre injury activities of daily living.
Activation of Heterophils and Monocytes in Chicken with a Formulation Containing a Seaweed Extract from Ulva armoricana
Authors: F Bussy
Published: August 2021

Responsiveness to invasive pathogens, clearance via the inflammatory response, and activation of appropriate acquired responses are all coordinated by innate host defenses. We have previously demonstrated that a purified ulvan extract of Ulva armoricana is able to activate avian heterophils and monocytes in vitro and in vivo , leading to in vivo release of cytokines including interleukin 1 β (IL1β), interferon α (IFNα) and interferon γ (IFNγ), in a transient and dose-dependent manner. In this study, we used the same protocol to evaluate a formulated version of this extract, called Searup ® . Our experiments showed that a single oral administration of this product at the dose recommended for use in the farm, results in heterophils and monocytes activation. In heterophils, activation was evidenced by β-D-glucuronidase release and increased mRNA expression of IL1β, IFNα and IFNγ. In monocytes, the expression of IFNγ and inducible nitrite oxide synthase (iNOS) were also up-regulated. Finally, plasmatic NO increased significantly on day 1, decreased on day 2 and was no longer significant at day 3. A similar pattern was observed for β-D-glucuronidase and for the modifications of the transcription profiles in monocytes as well as in heterophils. The only notable exception is gene transcription of 2'-5' Oligoadenylate Synthase, which is maximal at day 2 in monocytes. Due to its protective role in virus infection, this may constitute an additional layer of protection for this class of pathogens. Together our results show that the formulated solution, Searup ® , similarly to the purified extract allow to activate monocytes and heterophils but with some variations in the cytokines profiles and may provide protection against a larger variety of pathogens.
Complexity in the tourism and hospitality online purchasing process
Authors: Pappas Nikolaos , Papatheodorou Andreas
Published: August 2021

This chapter examines the complexity of attributes affecting the online purchasing process in tourism and hospitality. Eight elements (i.e. marketing activities, perceived benefits, perceived risks, over-choice confusion, price issues, quality issues, consumer trust and intention to purchase) are identified as of principal importance. Based on a sample of 735 holidaymakers, the empirical findings stress the role of perceived benefits in e-marketing activities; the significance of perceived risks for price and quality issues; and the importance of over-choice confusion to e-shopping. The research employs Qualitative Comparative Analysis (QCA), an innovative technique in tourism. QCA results are compared to regression highlighting the possible superiority of this non-linear mixed method against correlational analysis. The chapter progresses from fit to predictive validity, something that only a handful of studies have employed in tourism and hospitality, and generally in the service sector. It also discusses several theoretical, methodological and managerial implications, whilst it contributes in both, theoretical and methodological domains.
An exploration into Gen Ys attitudes and behaviour towards volunteering whilst backpacking
Authors: Jelaca Elena , Azara Iride , Michopoulou Eleni
Published: August 2021

This study focuses on Generation Ys’ attitudes and behaviour towards engaging in volunteer tourism whilst backpacking. To that end, we first examine Gen Ys’ generational characteristics and the predominant attitudes and behaviours displayed by this generational cohort. Then the focus is shifted to understanding Generation Y as backpackers and their internal and external motivations. These motivations are queried under the prism of volunteer tourism; being seen as factors determining the level of engagement with volunteer tourism and overall backpacking behaviour while travelling. This chapter provides insights into the themes described above by examining the relevant tourism literature. Finally, it summarises the theoretical gaps in the extant literature and sets objectives for future research, whilst signposting authors to key literature sources.
Creating a better future for the hospitality and tourism education
Authors: Dimitriou Christina
Published: August 2021

In recent years, countless hospitality and tourism programs have been experiencing low enrollment, budgetary issues, low scores in the college rankings, and failure to secure good job opportunities for their graduates. This occurs due to the implementation of unethical hiring and recruiting practices for faculty and staff, poor decision-making over key operational areas, abusive supervision, lack of ethical leadership, and careless strategic planning. However, the major reason is that there has been a huge gap between the hospitality and tourism academia and the industry which keeps growing. This is a rapidly changing industry where new trends are constantly emerging, new technologies are introduced, and innovative strategies arise. Meanwhile, hospitality and tourism programs around the world fail to understand the ever-changing industry trends, adapt to the new standards, and revise their curriculum accordingly. COVID-19 was the final blow that pushed academic institutions to their limits and created additional challenges. This chapter aims to address the issues that the hospitality and tourism academia has been struggling with, offer practical recommendations that will help tackle its operational difficulties, provide top quality education, prepare the leaders of tomorrow effectively, and bring it closer to the industry.
Critical Analysis of Governance, Economic Freedom, and Human Capital Implications on Sustainable Economic Growth: Evidence from Sub-Saharan Africa
Authors: Ayodeji Yusuf Ayotunde
Published: August 2021

In the recent time, the attention of scholars have shifted towards deeper understanding of factors that drives the achievement of sustainable economic growth, but yet factors such as governance, economic freedom, and human capital have not been exhaustively investigated, especially within the context of Sub-Saharan Africa (SSA). Thus, this study investigates the implications of governance, economic freedom, and human capital on the sustainability of economic growth in the SSA, usingpanel data that spanned between 1996 and 2018, and employed a Pooled Mean Group (PMG) estimator for the analysis. This study found governance, economic, and human capital to have a positive and significant causal relationship with economic growth in the long-run, while only economic freedom was found to have a negative and significant causal relationship with economic growth in the short-run. In addition, this study found that in case of disequilibrium, the model has a convergent speed of adjustment of about 10.8%. The study implications were discussed in the study.
Research on the state of young hockey players’ pre-competitive psychological fitness
Authors: Nakhodkin Vasiliy , Khvatskaya Elena , Ilina Natalia , Andreev Vitaly , Andreev Vladimir
Published: August 2021

The article presents the results of psychological research and psychologist’s work with young hockey players at two stages of pre-competition training camps for sports training for the 1st Winter Children of Asia International Sports Games (hereinafter – the 1st Winter ISG “Children of Asia”). The research involved studying the young athletes’ psychological fitness by three indicators: the status of pre-competition mental states (motivation and anxiety), autonomic balance and psychomotor control, as factors of psychological selection to a sports team and solving key problems in the content of integrated sports training. The research presents the annual cycle of young athletes’ sports training, which is timely at the stages of basic training and sports excellence.
Impact of Priority Sector Lending on Financial Profitability: Segment Wise Panel Data Analysis of Indian Banks
Authors:   Chimanbhai Patel Institute of Management and Research, Desai Rajesh
Published: August 2021

A sustainable and financially stable banking system is a prerequisite to achieve comprehensive growth as well as economic and social well-being of residents of any country. This research focused on analyzing profitability of Indian banks and how it is affected by lending in the priority sector. Priority sector lending (PSL) mainly includes deployment of credit to weaker and neglected segments of an economy. The study adopted a distinctive measure to represent total PSL by classifying it into four sub-segments i.e., agriculture, industrial, service, and personal credit. Applying panel least square regression with fixed and random effects model, the study concluded that agricultural lending has a significant negative impact on bank profitability whereas the service sector lending adds positive value towards financial profitability of banks. Industrial and personal credit were found to be insignificant factors affecting profitability. The study will be beneficial to banking professionals and policy makers to determine sensitive and risky sectors of lending and develop appropriate approaches to deal with them.
When an old pigmented lesion becomes serious: the problematic diagnosis of low-grade skin malignancies – Bednar tumor with fibrosarcomatous transformation
Authors: Dumitru Adrian , Ciongariu Ana , Aliuş Cătălin , Dumitrescu Dan , Iordache Sergiu Andrei , Şerban Bogdan , Ionescu Doris , Costache Mariana , Sajin Maria , Tapoi Dana
Published: August 2021

Bednar tumor is a rare cutaneous neoplasm, regarded as a variant of dermatofibrosarcoma protuberans with melanotic colonization and it usually affects young and middle-aged adults or children. This lesion is considered a low-grade malignant tumor, which can be associated with multiple local recurrences after surgical excision. Although a rare phenomenon, these lesions may undergo fibrosarcomatous transformation, which implies a poorer prognosis of the disease, as the tumor has a more locally aggressive behavior and patients might also develop distant metastases.

We present the case of a 53-year-old female patient, with no significant medical history, who presented with a subcutaneous nodule on her upper back, for which a wide surgical excision was performed. The gross examination of the specimen showed a solitary protuberant grey-white nodule with a bluish shade and flecked with pigment. The microscopic examination revealed a malignant proliferation with a predominantly fascicular growth pattern, composed of spindle cells with highly pleomorphic nuclei and high mitotic rate, as well as the presence of dendritic cells with abundant melanin. Upon immunohistochemical analysis, the proliferation showed negative staining for CD 34 and AE 1/3, whereas the scattered dendritic cells stained positive with S100 protein. Ki 67 was positive in 15% of the tumor cells and the absence of p53 expression was noted. Thus, the diagnosis of Bednar tumor with fibrosarcomatous transformation was established.

The aim of this paper was to gain further knowledge about the histopathological and immunohistochemical features, as well as about the treatment of Bednar tumor, especially considering its rarity.
The Sōka Gakkai 1968 Youth Movement: The Creation of Conviviality and Friendship in Sino-Japanese Relations
Authors: Fisker-Nielsen Anne Mette
Published: August 2021

This article discusses an episode in the history of Sōka Gakkai that began as alternative youth movement under Ikeda Daisaku who came to advocate “people’s diplomacy” (minkan gaikō) as a way to foster goodwill between China and Japan. Why would Sōka Gakkai, a legally constituted “religious corporation” (shūkyō hōjin) be so serious about engaging with a Communist regime that did not recognise religion? The article discusses what “religion” or “religious behaviour” means in Sōka Gakkai, and questions the usefulness of such a classification on a qualitative level. Ikeda’s interpretation of Nichiren Buddhism highlights his approach to something seemingly very “unreligious”—namely, the normalisation of Sino-Japanese relations. Unlike the more traditional “reactive revolution” of protest movements that constructed politics as primarily a binary, ideological choice to achieve its aims, Ikeda prioritised finding ways to transcend that very ideology-centric, counter-politics approach. By appealing to conviviality, a sense of shared humanity and humility on the part of the Japanese towards their past history of colonialism, a new social imaginary and attitude that differed from politics of opposition between left and right entered as a historical force that continues to be promoted by Sōka Gakkai today.
EMPIRICAL STUDY ON ALTERNATIVES FOR SAVING AND INVESTING IN THE POSTPANDEMIC PERIOD. CASE STUDY: ROMANIA
Authors:   Bucharest University of Economic Studies, Romania, Alexandru Mihai Alexandru Mihai , DINULESCU Ruxandra ,   Bucharest University of Economic Studies, Bucharest, Romania, PUCHEANU Florin ,   Bucharest University of Economic Studies, Bucharest, Romania
Published: August 2021

This paper develops investigations in the field of saving and investing techniques related to the impact of the COVID19 pandemic on the Romanian trading market. The study focuses particularly on the alternatives for accumulation of money capital which can lead to a positive long-term return. The research aims to investigate the available current services and opportunities in the Romanian investment market and their returns after the pandemic. Towards this objective, the study presents the past returns for several products and the users potential risks. Furthermore, an investigation is conducted based on the latest statistics whereas different variants of portfolios are presented. Unlike most of the previous studies, this analysis has a double approach: evaluating viable alternatives depending on several characteristics and simultaneously developing a long-term potential strategy that could be used to ensure the financial future of an individual in the period of the outbreak of the COVID19 pandemic. This contribution provides an initial analysis of the saving and investing market of Romania before and after the pandemic.
On the formation of the first Soviet industrial service of dosimetric control at the Ural nuclear plants (1945–1960)
Authors: Bochkareva Irina Alekseevna
Published: August 2021

The subject of this research is the process of organizing dosimetric service on the example of the Ural nuclear complex, primarily, the most powerful plutonium plant, the pioneer of the domestic nuclear industry – “Mayak” chemical plant in the 1945 – 1960. In the course of development of complex and hazardous for people and nature nuclear technologies, the problems of radiation protection of personnel at the first nuclear facilities became urgent, as most employees have been exposed to radiation. This required a set of emergency measures to create of safe working conditions and organize dosimetric control of nuclear energy workers. Based on the declassified archival documents, a substantial part of which is being introduced into the scientific discourse for the first time, as well as the reminiscences of the Soviet nuclear project participants, the article describes the peculiarities of formation of the first domestic service of industrial dosimetry, and provides periodization of this process. This defines the scientific novelty of the research. The use of historical and genetic method allowed outlining the prerequisites for the creation of the service of dosimetric control of the nuclear energy workers, its conditionality by the specificity of implementation of the Soviet uranium project, and a range of attendant problems. The method of historical periodization determined the key stages in organizing the dosimetric service in the context of establishment of the nuclear industrial complex. The historical-retrospective method allowed assessing the results of the activity of the scholars, leadership of the chemical plant “Mayak”, experts of dosimetric service aimed at solution of the issues related to radiation protection from the standpoint of time distance. The conclusion is made that the first domestic dosimetric service formed during the difficult period of the development of plutonium production in the Ural Region and committed work of its employees considerably contributed to ensuring safety of working conditions and preserving health and lives of thousands of the participants of the crucial for the country nuclear project
Damping of coupled bending-torsion beam vibrations by a two-dof tmd with analogous coupling
Authors: Høgsberg Jan
Published: August 2021

Coupled bending-torsion vibrations of a beam with a single cross-section axis of symmetry are mitigated by a two-degree-of-freedom (dof) tuned mass damper with a coupling analogous to that of the beam. By modal truncation a four-degree-of-freedom model is derived for tmd tuning. Because of the analogous tmd properties, a stiffness tuning formula identical to that for the classic tuned mass damper secures inverse relations between all four undamped natural frequencies. Expressions for the tmd damping are subsequently found by a numerical search, which maximizes the smallest of the four damping ratios, resulting in equal damping in three of the four modes. The two-dof coupled tmd is finally assessed by numerical root locus and frequency response analysis for a full flexible beam.
Immune-mediated adverse events in immune checkpoint inhibitors therapy: literature review
Authors: Lyadova Marina A. , Lyadov Vladimir K.
Published: August 2021

Immune-mediated adverse events (imAEs) are complications of therapy with immune checkpoint inhibitors, which arise as a result of autoimmune inflammation. The article summarizes systemic (fatigue, fever), cutaneous (rash, itching), gastrointestinal (diarrhea, colitis, hepatitis, pancreatic dysfunction), endocrinological (hypothyroidism, hypophysitis, adrenal insufficiency, diabetes mellitus), pulmonary (pneumonitis, pleuritis), rheumatological (arthralgia), neurological (headache, sensory and motor disorders), renal (acute interstitial nephritis, lupus-like nephritis, granulomatous nephritis, diffuse interstitial nephritis and minimal change disease), hematological (anemia, cytopenia), cardiovascular (myocarditis) and ocular (conjunctivitis, episcleritis, ceratitis, blepharitis and uveitis) imAE. Pathogenetic mechanisms and treatment approaches (in accordance with toxicity grade and clinical recommendations) are discussed. Early symptom recognition, patient education and timely intervention are crucial for imAE correction.
Experience of the department of surgical treatment of bone and soft tissue tumors during COVID-19 pandemic period
Authors: Bukharov Artem V. , Derzhavin Vitalii A. , Yadrina Anna V. , Erin Dmtrii A.
Published: August 2021

Since December 2019 the new coronavirus disease (COVID-19) has hit the world, causing the World Health Organization to declare it a pandemic. With the emergence and spread of the new infection, there has been unprecedented pressure on health care systems around the world. The time constraints associated with receiving routine care also affected the risk group cancer patients, as some hospitals were quarantined. Violation of the terms of both systemic drug, radiation and surgical treatment of cancer patients could lead to the progression of the tumor process and lead to the death of the patient. In connection with the current situation, doctors had to quickly change the tactics of managing cancer patients, due to the lack of accurate data on the basis of which it is possible to determine the optimal approach to the use of therapy, they had to make decisions in conditions of lack of data. The article shows an example of the treatment of 113 patients being treated in the department of surgical treatment of bone and soft tissue tumors in National Medical Research Radiological Center of the Ministry of Health of Russia during the first wave of the pandemic from March 30 to July 1, 2020. Surgical treatment was performed in 103 patients. During the period of stay in the hospital, 11 patients showed signs of coronavirus infection. Of these, 10 patients were diagnosed with coronavirus infection in the postoperative period. According to the study, the nosocomial incidence of COVID-19 is 10%. With timely diagnosis and specialized treatment, the survival rate was 100% in the given example. Consequently, if epidemiological measures are observed at all stages of hospitalization, it is possible to carry out planned surgical treatment for patients with primary and secondary lesions of bones and soft tissues. However, the decision to carry out a planned operation during a pandemic should be individual for each patient.
Isatuximab, a novel anti-CD38 monoclonal antibody in the treatment of multiple myeloma: efficacy and safety
Authors: Zatolochina Karina E. , Zyryanov Sergey K. , Ushkalova Elena A.
Published: August 2021

The article discusses the place of CD38 antibodies in the treatment of multiple myeloma (MM). Special emphasis is put of isatuximab. In 2020, isatuximab in combination with pomalidomide and dexamethasone was approved in Russia for the treatment of adult patients with MM who have received at least two lines therapies, including lenalidomide and a proteasome inhibitor. The published data from studies of isatuximab, demonstrating its clinical efficacy and safety in combination with standard treatment regimens for recurrent/refractory MM, are discussed.
Acalabrutinib in the treatment of chronic lymphocytic leukemia: a review of recent evidence
Authors: Petrenko Andrei A. , Kislova Maria I. , Dmitrieva Elena A. , Nikitin Eugene A.
Published: August 2021

Chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically with the recently developed drugs targeting the B-cell receptor (BCR) signalling pathway. Acalabrutinib, a second generation Bruton tyrosine kinase inhibitor, was approved in 2020 in Russia for the treatment of patients with CLL. Acalabrutinib was developed as a more selective Bruton tyrosine kinase inhibitor then ibrutinib. This drug is aimed at reducing the adverse events that limit the use of ibrutinib, such as atrial fibrillation and bleeding. Phase I/II multicenter studies have demonstrated the efficacy and safety of acalabrutinib monotherapy in untreated CLL patients and in patients with relapsed/refractory CLL and ibrutinib intolerance. Phase III trials, ASCEND and ELEVATE-TN, compared acalabrutinib monotherapy and a combination of acalabrutinib and obinutuzumab versus standard therapies and demonstrated improved efficacy and tolerability of acalabrutinib. A phase III trial comparing acalabrutinib and ibrutinib monotherapy (ELEVATE-RR) is ongoing. The results of this study along with real-life clinical data could determine the place of acalabrutinib in CLL treatment.
AVALIAÇÃO DO TEMA GERADOR SOLOS COMO PROPOSTA INTERDISCIPLINAR NO ENSINO DE QUÍMICA
Authors: Sivico Mayki Jardim , Mendes Ana Nery Furlan
Published: August 2021

A interdisciplinaridade na Educação Básica reflete uma necessidade de tornar o conhecimento mais integrativo no ambiente escolar, sendo imprescindível diálogo cada vez mais amplo entre as disciplinas nesse processo. A presente pesquisa se fundamenta nas frentes teóricas de Vygotsky e de Freire, a partir de uma relação dialética, com o objetivo de analisar as percepções e potencialidades do desenvolvimento de uma prática metodológica interdisciplinar, por meio da realização do grupo focal, envolvendo as disciplinas de Geografia e Química, a partir do tema gerador “solos”, com a turma da 1ª série do Ensino Médio de uma escola da rede pública estadual, no município de Nova Venécia (ES).  Em relação à abordagem, trata-se de uma pesquisa qualitativa, do tipo participante, e os dados coletados durante as discussões do grupo focal passaram por processo de categorização para fins de análise do conteúdo. A análise das categorias identificou a necessidade de levar para o aluno metodologias que protagonizem as aprendizagens deles, contribuindo para a formação de sujeitos críticos e reflexivos. Por fim, verificou-se que ao utilizar o tema gerador mencionado, numa perspectiva interdisciplinar, foi possível identificar outras vias oportunas ao aprendizado de Química.
Study on variations in hilar and segmental branching pattern of splenic artery
Authors:   Assistant Professor, Department of Anatomy, Shri. Bhausaheb Hire Government Medical College, Dhule, INDIA., Sarda Swapnilkumar L
Published: August 2021

Background: Introduction of laparoscopic surgical methods requires exact knowledge of the topography of the spleen and its surrounding. Further advances in splenic conservative surgery are dependent on better knowledge of vascular anatomy of the spleen. Hence segmental arteries of spleen are of great surgical importance and their early identification in splenic trauma will lead to enhanced splenic conservation. Materials and methods: Present study carried out on 50 human spleen by dissection, silicon injection and radiological methods. We found different types of variations in hilar and segmental branching pattern of splenic artery. Observations and Results: in present study splenic artery divided in two primary branches in 86% and in three primary branches in14% of the spleens. superior polar branches were found in 44% while inferior polar branches were in 52% of the spleens. Two segmental branches found in 24%, three segmental found in 50%, four segmental in 18% and five segmental in 8% of the specimens. Intersegmental anastomosis found in 2% of spleens. Discussion: These segmental resection of spleen and further advances in splenic conservation are dependant on better understanding of vascular anatomy of the spleen.
A comparative study of dexmedetomidine propofol and midazolam with respect to changes in mean arterial pressure and SpO2 after sedation at tertiary health care centre
Authors:   Assistant Professor, Department of Anaesthesia and Critical Care Medicine, Institute of Liver and Biliary Sciences, New Delhi, INDIA., Gupta Surabhi
Published: August 2021

Background: Sedation is an important component of compassionate care in ICU patients to promote rest and sleep. The sedatives used most often include propofol and midazolam. These medications provide adequate sedation but also can cause oversedation. The α2 agonist dexmedetomidine have unique sedative properties that it produces only mild cognitive impairment, allowing easy communication between health-care provider and patient in the ICU. We therefore compared the sedative and analgesic properties, cardiovascular responses, ventilation and extubation characteristics, and patient perceptions of dexmedetomidine with those of the commonly used i.v. sedative agent propofol in the ICU. Material and Methods: Present study was a randomized. open label trial conducted in the ICU ppatients >18 years of age, who required immediate sedation as to permit the initiation and tolerance of mechanical ventilation. 30 patients each were randomly allocated to dexmedetomidine, propofol & midazolam group. Results: Male predominance was noted, in all groups (dexmedetomidine, propofol & midazolam), M:F ratio was 1.3 : 1. According to age distribution most common age group in dexmedetomidine, propofol & midazolam group was 31-45 years (40 %). At all times the difference in systolic blood pressure, diastolic blood pressure, SpO2, mean arterial blood pressure among all the three groups calculated by ANOVA test was not statistically significant (P>0.05). The mean time (hours) from cessation of sedation to extubation for dexmedetomidine is 7.4 hours, for propofol is 5.6 hours and for midazolam is 16.9 hours. P-value of dexmedetomidine, propofol and midazolam group is <0.001, which is statistically significant. Conclusion: Dexmedetomidine provides hemodynamic stability and have no clinically important adverse effects on respiration in terms of mean SpO2. Tracheal extubation was earlier in patients receiving dexmedetomidine and propofol than from midazolam.
Role of pulse plethysmograph in the prediction of hypotension in caesarean section patient under spinal anesthesia
Authors:   Assistant Professor,Department of Anesthesiology,  D.Y. Patil Medical College, D. Y. Patil Education Society (Deemed University), Kolhapur-416 006, Maharashtra, INDIA., Desai Sheetal K
Published: August 2021

Background: Spinal anesthesia is a commonly employed technique for anesthesia for caesarean section and is associated with hypotension which may cause maternal morbidity. Prediction of hypotension before the procedure can reduce complications. The study aimed to evaluate the role of pulse plethysmograph in the prediction of hypotension in caesarean section patients under spinal anesthesia. Methods: The observational study was conducted on 50 patients who were undergoing emergency or elective caesarean section. Spinal anesthesia was performed by anaesthesiologist using a 25 or 26-gauge spinal needle with bupivacaine at L3-4 interspinous space. Pre and post-anesthesia observations such as the width of pulse plethysmograph, non-invasive blood pressure in another arm, and heart rate were recorded. Paired T-test, Wilcoxon sign rank test, and chi-square test was used to analyse data using R Studio V 1.2.5001 software. Results: Post spinal anesthesia minor fall in systolic blood pressure (SBP) was observed in 11 patients, moderate fall in 21 patients, severe fall in 8 patients and a massive fall in 10 patients. A significant difference was observed between mean pre- and post-spinal anesthesia SBP (P<0.001). Width of pulse plethysmograph (PPG) was maintained in 14 patients whereas, narrowed and significantly narrowed PPGs were observed in 29 and 7 patients, respectively. Significant association was observed between grades of SBP and width of PPG (P<0.05). Receiver operating characteristic curve showed the width of PGG was good for prediction of hypotension in patient (AUC=0.828). Conclusion: Width of PPG can be used to predict SA induced maternal hypotension.
Психиатрический и аддиктивный профиль несовершеннолетних Забайкальского края, оставшихся без попечения родителей
Authors: Бодагова Е.А. , Говорин Н.В. , Сахаров А.В.
Published: August 2021

Актуальность. Сохранение психического здоровья детско-подросткового населения РФ в связи с тенденцией к росту распространенности психических расстройств и аддиктивного поведения является приоритетной задачей современной психиатрии. Патологические формы поведения считаются детерминистическим предиктором употребления ПАВ несовершеннолетними. Отечественные и зарубежные авторы делают акцент на необходимость всестороннего изучения психического здоровья детей-сирот. Цель: установление частоты встречаемости и клинико-нозологической структуры психических и аддиктивных расстройств у детей и подростков Забайкальского края, оставшихся без попечения родителей. Результаты. В настоящем исследовании представлены результаты сплошного клинико-эпидемиологического обследования 516 несовершеннолетних Забайкальского края, оставшихся без попечения родителей. Подавляющее большинство воспитанников детских домов являются социальными сиротами (96,7%) и имеют отягощенную наследственность по алкоголизму родителей (86,6%). Выявлена высокая частота (69,4%) встречаемости психической патологии у несовершеннолетних сирот, преимущественно за счет легких когнитивных расстройств (F06.7), расстройств поведения (F91-F92) и расстройств психологического развития (F83). Наркологические расстройства у воспитанников детских домов выступают коморбидными психическим расстройствам и встречаются в 21,3% случаев, в структуре которых преобладает употребление алкоголя с вредными последствиями (F10.1) – 84,5%. Установлено, что сироты, злоупотребляющие алкоголем (F10.1), в сравнении с психически здоровыми сиротами значимо чаще отличаются высокими показателями агрессивности (44,0%), враждебности (64,5%), частыми антидисциплинарными и антиобщественными поступками, а также совершением общественно опасных деяний (52,7%). В связи с полученными данными имеет весомое значение разработка комплекса профилактических программ для внедрения в центрах проживания сирот детского и подросткового возрастов.
Клинико-синдромологические особенности интоксикационных психозов, вызванных употреблением современных синтетических психоактивных веществ
Authors: Афанасьева Н.А. , Коробицина Т.В. , Пичугина Ю.А. , Юков О.С. , Ширшова А.А.
Published: August 2021

Актуальность. Непрекращающееся производство заново синтезируемых аналогов синтетических наркотиков с немедленной их поставкой на наркорынок отражает тенденцию роста масштабов злоупотребления веществами, находящимися под международным контролем. Комплексный анализ клинической картины интоксикационных психозов и медико-социальных последствий употребления современных синтетических психоактивных веществ позволит разработать терапевтические подходы к лечению и реабилитации таких больных. Цель. Изучить особенности психозов, развившихся на фоне потребления синтетических психоактивных веществ. Материал исследования. Сформированы три группы пациентов (всего 318 мужчин, средний возраст 35,7±7,4 года) в соответствии с длительностью психотического периода. Методы: клинико-психопатологический, анамнестический, катамнестический, газожидкостная хроматография. Результаты. Получены данные об особенностях клинической картины психотических осложнений в зависимости от продолжительности психоза, а также выявления психоактивного вещества в биологических жидкостях организма пациентов. Заключение. Определены клинико-синдромологические особенности психотических расстройств, развившихся на фоне употребления новых синтетических психостимуляторов и каннабиноидов. При практически одинаковом симптомокомплексе в клинической картине таких психозов отмечены определенные отличия с учетом продолжительности психотических осложнений.
Estimating Global Solar Radiation from Empirical Models: An Application
Authors: BALLİ Özgür
Published: August 2021

Solar radiation data are required for many applications and many areas of research. In order to achieve this, several empirical models have been suggested to predict the global solar radiation in Turkey and other countries. The different meteorological data as the global solar radiation, the sunshine duration, the temperature, the atmospheric pressure, the wind speed and the relative humidity were measured by Eskisehir Osmangazi University during the period between 01 January 2011 and 31 December 2014. These data were used to develop the empirical models in order to estimate the monthly average daily global solar radiation on the horizontal surface over Eskisehir City of Turkey. The developed empirical models were analyzed with the widely used nine statistical methods, namely; the relative percentage error (E), the mean percentage error (MPE), the mean absolute percentage error (MAPE), the sum of squares of relative errors (SSRE), the relative standard error (RSE), the mean bias error (MBE), the root mean square error (RMSE), the t-statistic method (t-stat) and coefficient of determination (R2). It is expected that the new model will be beneficial to everyone who is the solar engineers, architects, agriculturists, and hydrologists involved or interested in the design and study of solar energy applications such as solar furnaces, wood drying, stoves, concentrating collectors, interior illumination and thermal load analyzing of buildings, and photovoltaics, agricultural and meteorological forecasting.