bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Weight-based Dosing of Intravenous Immunoglobulin (IVIG)
among Overweight and Obese Patients
Authors: Heidari Shima , Shahrami Bita , Sadeghi Kourosh
Published: October 2023

Background:

Intravenous immunoglobulin (IVIG), as an expensive medication under a national
shortage, has been widely used for the treatment of several autoimmune diseases and immunodeficiency
syndromes. Although conducting studies on therapeutic indications of IVIG has increased
significantly, a limited number of researches have investigated individualized dosing in terms of the drug,
disease state, and some patient-specific factors like obesity.

Objective:

The objective of the review was to describe the impact of various weight-based dosing regimens
on the pharmacokinetics parameters, efficacy, safety, and cost of IVIG and to choose the best dosing
approach for obese patients.

Methods and Results:

Thirteen of the total 128 manuscripts collected, reviewed, and analyzed were
found from Scopus, PubMed, and Google scholar.

Discussion:

The evidence suggests that obesity may have an impact on IVIG pharmacokinetics, safety,
and efficacy.

Conclusion:

The logical approach is to initial the dose based on the ideal or adjusted body weight and
then modify the maintenance dose according to the patient's clinical response.
Progress in Zero-gravity Unloading Test and System Research of Solar
Wing
Authors: Hou Zemiao , Li Qiu , Wu Yuemin , Yu Qiang , Liang Hongfei
Published: October 2023

Aim:

The solar wing undertakes the important task of providing energy for spacecraft.
The deployment test of the solar wing in a zero gravity environment using a zero gravity system
on the ground is an important link to ensure the safe and stable deployment of the solar wing in
space. This article briefly describes the development process and research progress of solar wings,
introduces the ground zero gravity test methods and test platforms for solar wings, including some
patents for improving the ground zero gravity test platform for solar wings, and points out some
urgent problems that need to be solved in the zero gravity unloading test and system at present.

Background:

The solar wing needs to be deployed in the weightlessness environment of space
before working.

Objective:

The objective of this study is to summarize the zero gravity experimental methods and
systems of solar wings, introduce their categories, characteristics, and development.

Methods:

This article summarizes various scientific research achievements in the zero gravity test
of solar wings, and introduces the advantages and disadvantages of the zero gravity test method of
solar wings.

Conclusion:

Although research on zero-gravity unloading test systems for solar wings is continuously advancing, there are still several technological bottlenecks that need to be overcome in
terms of system precision, payload capacity, dynamic simulation, method optimization, diversifying zero-gravity test methods and system universality for different types of solar panel unloading.
Investigation of Therapeutic Potential of Biosynthesized Silver and Gold
Nanoparticles Using Extract of Wrightia tinctoria
Authors: Kadam Shivani V. , Magdum Chandrakant S. , Kane Sandip R. , Bhutkar Mangesh A. , Randive Dheeraj S. , Bhinge Somnath D. , Sonawane Kailas D.
Published: October 2023

Background:

In Indian traditional medicine, the seeds and bark of Wrightia tinctoria are
utilized as remedies for antidiarrheal and antidysenteric purposes, as well as for other medicinal uses.

Aim:

The primary aim of the study was to explore the green synthesis of silver and gold
nanoparticles by employing an extract obtained from the Wrightia tinctoria plant and to explore their
potential medicinal properties.

Objective:

This study involved the characterization of the nanoparticles in terms of their properties
and quality, as well as an investigation of their potential anti-bacterial, anticancer, and antiinflammatory
properties.

Methods:

Various characterization techniques, including UV spectroscopy, XRD spectra, FTIR,
SEM, particle size and zeta potential analysis, were used in this study for the synthesized
nanoparticles. Our study investigated the impact of concentration, pH, and incubation time on
nanoparticle synthesis, providing a comprehensive description of the synthesis procedure for both
silver and gold nanoparticles.

Result:

Experimental findings confirmed that silver and gold nanoparticles derived from Wrightia
tinctoria exhibited irregular shape, with an average diameter ranging from approximately 0.08 to
0.34 μm and 0.09 to 0.30 μm, respectively. Appreciably, the biologically synthesized WTAgNPs and
WTAuNPs demonstrated promising antibacterial, anticancer, and anti-inflammatory properties
without any signs of toxicity. The enhanced biological activity of WTAgNPs and WTAuNPs can be
attributed to their distinctive properties at the nanoscale, as both exhibit lower polydispersity and
average particle size, contributing to increased reactivity and interactions with biological systems.

Conclusion:

The nanoparticles synthesized through the biogenic approach using Wrightia tinctoria
extract have immense potential for a wide range of pharmaceutical applications.
MicroRNAs and Diet-induced Weight Loss: What’s the Link?
Authors: Cannataro Roberto , Abrego-Guandique Diana M. , Caroleo Maria C. , Bonilla Diego A. , Cione Erika
Published: October 2023

It is now well established that lifestyle, particularly eating habits, modulates the syn-thesis and action of microRNAs (miRNAs). In particular, several nutritional schemes have proven effective in improving body composition, but molecular mechanisms still need to be fully under-stood. Within the complex physiological network of food intake regulation, it is essential to un-derstand the changes in endocrine activity after the reduction of adipose tissue during a weight loss program. This could be the key to identifying the optimal endocrine profile in high respond-ers, the assessment of musculoskeletal status, and long-term management. In this review, we summarize the state of the art regarding miRNAs as a function of weight loss and as a mechanistic regulator of the effectiveness of the nutritional program.
Formulation of Lipid Nanoparticles based Nanogel of Sertaconazole
Nitrate and its Evaluation
Authors: Pawar Sarvesh S. , Gadekar Punam S. , Rane Bhushan R. , Jain Ashish S.
Published: October 2023

Background:

Sertaconazole nitrate is a topical antifungal drug used to treat interdigital tinea pedis in patients with immunocompetent conditions. The class of imidazole includes the antifungal medication sertaconazole nitrate. It is available in topical formulations for treating skin infections, including athlete's foot. Solid lipid nanoparticles (SLN) are at the cutting edge of nanotechnology, with several potential uses in drug delivery and research. Because of their unique size-dependent features, lipid nanoparticles hold the promise of novel therapies.

Objective:

Drug incorporation into nanocarriers creates a new drug delivery prototype that could be employed for drug targeting. The research aims to study the formulation and evaluation of Sertaconazole nitrate solid lipid nanoparticles. The goal behind formulating SLN gel is to provide and maintain therapeutic concentrations of the drug at the target biological site to maximise therapeutic efficacy and minimise side effects.

Methods:

Sertaconazole Nitrate Solid Lipid Nanoparticles are prepared by using High Pressure Homogenizer to get nanogel formulation as the final formulation and In-vitro drug release using a diffusion apparatus. The prepared SLNs were evaluated in their FTIR studies to determine compatibility between the drug and the excipients; zeta potential indicates the solid lipid nanoparticle was stable, and polydispersity index was used to determine particle size.

Result:

The results demonstrate that optimised SLN-based Sertaconazole nitrate gel exhibited the best physicochemical properties, including FTIR studies of the drug, excipients, and optimised formulation demonstrate that all are compatible with each other, particle size is less than 200 nm, zeta potential ranging from 12 to -20 mV, and highest entrapment efficiency is 71.48%. Optimised solid lipid nanoparticles showed good in vitro release and antimicrobial results. The main application of SLN large scale-up is possible, and the drug can be effective with less dose incor-poration.

Conclusion:

In this research work, the proposed plan of work SLN of Sertaconazole Nitrate was formulated successfully. The preliminary identification tests were performed, such as melting point determination, estimation of λmax by UV-visible spectrophotometry and plot of its calibration curve in solvent and buffer system, and FT-IR investigation to confirm the purity and confirmation of medication. High physical stability and drug loading are advantageous to SLN.
Ultrastructural Blood Cell Changes in Patients with COVID-19
Authors: Kyyak Yulian , Barnett Olga , Halkevych Marta , Labinska Olha , Kysil Orysia
Published: October 2023

Introduction::

Nowadays, the coronavirus disease COVID-19 is a global problem for the
population of the whole world which has acquired the character of a pandemic. Under physiological
conditions, in a healthy person, erythrocytes make up 96 % of all blood cells, leukocytes 3 %, and
thrombocytes about 1 %. In healthy individuals, erythrocytes are mostly shaped like a biconcave disc
and do not contain a nucleus. The diameter of the erythrocyte is 8 microns, but the peculiarities of
the cell structure and the membrane structure ensure their great ability to deform and pass through
capillaries with a narrow lumen of 2-3 microns. Therefore, the study of the morpho-functional state
of blood cells, namely erythrocytes, in this category of patients is relevant and deserves further research.

The Aim:

To figure out the effect of the coronavirus disease COVID-19 on the ultrastructural blood
cell changes, in particular erythrocytes, in patients with ischemic heart disease (IHD) and diabetes
mellitus type 2.

Materials and Methods:

Twelve patients with COVID-19 who had an acute myocardial infarction
were examined. The comparison group consisted of 10 people with acute myocardial infarction
without symptoms of COVID-19. The average age of the patients was 62 ± 5,6 years. The functional
state and ultrastructure of blood cells were studied using electron microscopy.

Results::

In the presence of COVID-19, we detected both calcification and destruction of erythrocytes
and platelets. Reticulocytes were detected much more often in these individuals than in the comparison
group. In patients with acute myocardial infarction in the presence of type 2 diabetes and
COVID-19, a significant number of markedly deformed, hemolyzed erythrocytes or with signs of
acanthosis, which stuck together and with other destructively changed blood cells, were found. We
also detected «neutrophils extracellular traps» (NETs).

Conclusions::

Morphological changes of blood cells in COVID-19 varied according to the disease
course and severity especially in the background of a weakened immune system in older and elderly
people, in the presence of diabetes, excessive body weight, cardiovascular diseases and occupational
hazards. Under the influence of COVID-19, blood cells are destroyed by apoptosis and necrosis.
Therefore, hypoxia and ischemia of vital organs of the human body occur.
The Association between Statins Intake and Risk of Post Stroke Pneumonia:
A Systematic Review and Meta-Analysis
Authors: Darvishi Mohammad , Amiri Mehdi Mohammadian , Heidari-Soureshjani Saeid , Sherwin Catherine M.T. , Mardani-Nafchi Hossein
Published: October 2023

Aim:

This research aimed to examine the relationship between the intake of statins and
the risk of post-stroke pneumonia in a systematic review and meta-analysis study.

Methods:

An extensive search of published articles on March 21st, 2023, was done in several databases,
like Web of Science (ISI), PubMed, Cochrane Library, Embase, Scopus, and Google Scholar.
The Newcastle Ottawa Scale (NOS) checklist was employed to evaluate the quality of observational
studies. Statistical tests (Chi-square test and I2) and graphical techniques (Forest plot) were used to
determine whether heterogeneity existed in the meta-analysis studies. Funnel plots and Begg and
Egger's tests were used to assess the publication bias.

Results:

Seven studies (5 cohort and 2 case-control studies) were retrieved to examine the association
between statins and post-stroke pneumonia. The sample size of the studies compiled in the meta-
analysis was obtained to be 68,966 participants. Meta-analysis demonstrated that the overall odds
of post-stroke pneumonia in the statin group was equal to 0.87 (95% CI: 0.67 – 1.13; p-value
0.458). Subgroup analysis indicated that the odds of post-stroke pneumonia in the statin group was
equal to 0.93 (95% CI: 0.73-1.18; p-value = 0.558) in the cohort studies, and equal to 0.92 (95% CI:
0.37-2.26; p-value = 0.857) in the case-control studies. The examination of the association between
the intake of statins and post-stroke pneumonia showed no evidence of publication bias (Begg's test,
p-value = 0.368; Eggers test, p-value = 0.282).

Conclusion:

In this study, no relationship has been observed between receiving statins and the risk
of post-stroke pneumonia.
Bioplaguicida Tricotec® WG para el control de Rhizoctonia solani (rizoctoniasis y costra negra) en el cultivo de papa
Authors: Beltrán Acosta Camilo Rubén , Zapata Narváez Yimmy Alexander , Zuluaga Mogollón María Victoria
Published: October 2023

Tricotec® WG es un fungicida biológico preventivo formulado como un granulado dispersable (WG). Su principio activo son conidios del hongo biocontrolador Trichoderma koningiopsis cepa Th003. Tiene un amplio espectro de acción contra fitopatógenos del suelo (ver recomendaciones de uso) y es una excelente alternativa para incluir en los planes de manejo integrado de enfermedades en cultivos de papa. Este producto es desarrollado por la Corporación Colombiana de Investigación Agropecuaria (agrosavia) y ha demostrado ser una alternativa de control de enfermedades en cultivos como complemento de otros métodos de control. Tricotec® WG también promueve el crecimiento de las plantas.
Immune-Boosting Effect of the COVID-19 Vaccine: Real-World Bidirectional Cohort Study
Authors: Liu Ming , Zhao Tianshuo , Mu Qiuyue , Zhang Ruizhi , Liu Chunting , Xu Fei , Liang Luxiang , Zhao Linglu , Zhao Suye , Cai Xianming , Wang Mingting , Huang Ninghua , Feng Tian , Lei Shiguang , Yang Guanghong , Cui Fuqiang
Published: October 2023

Background

As the SARS-CoV-2 attenuates and antibodies from the COVID-19 vaccine decline, long-term attention should be paid to the durability of primary booster administration and the preventive effect of the second or multiple booster doses of the COVID-19 vaccine.

Objective

This study aimed to explore the durability of primary booster administration and the preventive effect of second or multiple booster doses of the COVID-19 vaccine.

Methods

We established a bidirectional cohort in Guizhou Province, China. Eligible participants who had received the primary booster dose were enrolled for blood sample collection and administration of the second booster dose. A retrospective cohort for the time of administration was constructed to evaluate antibody attenuation 6-12 months after the primary booster dose, while a prospective cohort on the vaccine effect of the second booster dose was constructed for 4 months after the second administration.

Results

Between September 21, 2022, and January 30, 2023, a total of 327 participants were included in the final statistical analysis plan. The retrospective cohort revealed that approximately 6-12 months after receiving the primary booster, immunoglobulin G (IgG) slowly declined with time, while immunoglobulin A (IgA) remained almost constant. The prospective cohort showed that 28 days after receiving the second booster, the antibody levels were significantly improved. Higher levels of IgG and IgA were associated with better protection against COVID-19 infection for vaccine recipients. Regarding the protection of antibody levels against post–COVID-19 symptoms, the increase of the IgG had a protective effect on brain fog and sleep quality, while IgA had a protective effect on shortness of breath, brain fog, impaired coordination, and physical pain.

Conclusions

The IgG and IgA produced by the second booster dose of COVID-19 vaccines can protect against SARS-CoV-2 infection and may alleviate some post–COVID-19 symptoms. Further data and studies on secondary booster administration are required to confirm these conclusions.
Efficacy and Safety of Makabuhay (Tinospora rumphii) 25% Cream Versus Hydrocortisone 1% Cream in the Management of Mosquito Bite Reactions: Randomized Double-Blind Controlled Trial
Authors: Gatmaitan Julius Garcia , Gatmaitan-Dumlao Jolene Kristine Garcia , Dayrit Johannes , Gabriel Ma Teresita
Published: October 2023

Background

Most insect bite reactions resolve spontaneously, but the inflammation and pruritus induced have been shown to decrease the quality of life. Previous studies have shown the potential anti-inflammatory properties of Tinospora rumphii.

Objective

The aim of the study is to assess the efficacy and safety of T rumphii 25% cream versus hydrocortisone 1% cream in the management of local cutaneous reactions caused by mosquito bites.

Methods

This study was a parallel-group, double-blind, randomized, placebo-controlled trial with a 1-week duration in a span of 3 months (June 2019 to August 2019). Participants were exposed to sterile noninfectious mosquitoes (Aedes aegypti) for 5-10 minutes to elicit cutaneous lesions. Tinospora 25% cream or hydrocortisone 1% cream was applied twice daily throughout the 7-day study period. Of the 70 participants screened for this study, which was approved by an institutional review board (IRB 2019-07) at the Dermatology Outpatient Department of the Research Institute for Tropical Medicine, Alabang, Muntinlupa, Philippines, 58 participants in total met the inclusion criteria and were randomized to treatment (Tinospora: n=29) and active control (hydrocortisone: n=29) groups.

Results

In total, 58 participants were randomized to receive Tinospora cream (n=29) or hydrocortisone cream (n=29). All participants completed the follow-up. There was a significant decrease in lesion size in both groups from the first 15 minutes to day 7 (P<.001). Comparing the lesion size in both groups, there was a statistically significant decrease in lesion size in the first hour (P=.003) and after 24 hours (P=.03). On day 1, 10% (n=29) of participants in the hydrocortisone group and 7% (n=29) in the Tinospora group experienced complete resolution. On day 3, all participants experienced complete resolution. No adverse effects were documented.

Conclusions

Tinospora 25% cream is safe, effective, and comparable to hydrocortisone 1% cream as an anti-inflammatory agent for mosquito bite reactions based on the decrease in lesion size, the proportion of participants with complete resolution of wheals, and improvement in pruritus intensity score using a visual analog scale. Long-term safety studies are recommended.

Trial Registration

Philippine Health Research Registry PHRR230716-005932; https://www.herdin.ph/index.php/registry?view=research&layout=details&cid=5932
Mindful Self-Compassion Smartphone Intervention for Worker Mental Health in Japan: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Kurosawa Takumu , Adachi Koichiro , Takizawa Ryu
Published: October 2023

BACKGROUND

Mental health problems among workers cause enormous losses to companies in Japan. However, workers have been considered to have limited access to psychological support because of time constraints, which makes it difficult for them to engage in face-to-face psychological support interventions.

OBJECTIVE

This study aimed to present an intervention protocol that describes a randomized controlled trial to examine whether brief guided mindfulness meditation (MM) or self-compassion meditation (SCM) provided by a smartphone app is effective for mental health and work-related outcomes among workers.

METHODS

This is an open-label, 3-arm randomized controlled trial. The participants will be recruited through an open call on relevant websites with the following inclusion criteria: (1) employees who are working more than 20 hours per week, (2) between the ages of 18 and 54 years, (3) not on a leave of absence, (4) not business owners or students, and (5) not currently diagnosed with a mental disorder and have a Kessler Psychological Distress Scale-6 score below 13 points. We will include 200 participants and randomly assign them to an SCM course (n=67), an MM course (n=67), and a waitlist group (n=66). The intervention groups (SCM and MM) will be instructed to engage in daily guided self-help, self-compassion, and MMs lasting 6-12 minutes per day over 4 weeks. Primary outcomes will include psychological distress and job performance, and secondary outcomes will include somatic symptoms, cognitive flexibility, self-esteem, self-compassion, perceived stress, well-being, emotion regulation, work engagement, anger, psychological safety, and creativity. All procedures were approved by the ethics committee of the University of Tokyo (22-326). All participants will be informed of the study via the websites, and written informed consent will be collected via web-based forms.

RESULTS

The recruitment of participants began in December 2022, and the intervention began in January 2023. As of September 2023, a total of 375 participants have been enrolled. The intervention and data collection were completed in late October 2023.

CONCLUSIONS

This study will contribute to the development of effective self-care intervention content that will improve mental health, work performance, and related outcomes and promote mindful and self-compassionate attitudes when faced with distress.

CLINICALTRIAL

University Hospital Medical Information Network Clinical Trials Registry UMIN000049466; https://tinyurl.com/23x8m8nf

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/53541
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Europe: Longitudinal Trend Analysis (Preprint)
Authors: Lundberg Alexander L , Wu Scott A , Soetikno Alan G , Hawkins Claudia , Murphy Robert L , Havey Robert J , Ozer Egon A , Moss Charles B , Welch Sarah B , Mason Maryann , Liu Yingxuan , Post Lori A
Published: October 2023

BACKGROUND

In this study, we built upon our initial research published in 2020 by incorporating an additional 2 years of data for Europe. We assessed whether COVID-19 had shifted from the pandemic to endemic phase in the region when the World Health Organization (WHO) declared the end of the public health emergency of international concern on May 5, 2023.

OBJECTIVE

We first aimed to measure whether there was an expansion or contraction in the pandemic in Europe at the time of the WHO declaration. Second, we used dynamic and genomic surveillance methods to describe the history of the pandemic in the region and situate the window of the WHO declaration within the broader history. Third, we provided the historical context for the course of the pandemic in Europe in terms of policy and disease burden at the country and region levels.

METHODS

In addition to the updates of traditional surveillance data and dynamic panel estimates from the original study, this study used data on sequenced SARS-CoV-2 variants from the Global Initiative on Sharing All Influenza Data to identify the appearance and duration of variants of concern. We used Nextclade nomenclature to collect clade designations from sequences and Pangolin nomenclature for lineage designations of SARS-CoV-2. Finally, we conducted a 1-tailed t test for whether regional weekly speed was greater than an outbreak threshold of 10. We ran the test iteratively with 6 months of data across the sample period.

RESULTS

Speed for the region had remained below the outbreak threshold for 4 months by the time of the WHO declaration. Acceleration and jerk were also low and stable. While the 1-day and 7-day persistence coefficients remained statistically significant, the coefficients were moderate in magnitude (0.404 and 0.547, respectively; P<.001 for both). The shift parameters for the 2 weeks around the WHO declaration were small and insignificant, suggesting little change in the clustering effect of cases on future cases at the time. From December 2021 onward, Omicron was the predominant variant of concern in sequenced viral samples. The rolling t test of speed equal to 10 became insignificant for the first time in April 2023.

CONCLUSIONS

While COVID-19 continues to circulate in Europe, the rate of transmission remained below the threshold of an outbreak for 4 months ahead of the WHO declaration. The region had previously been in a nearly continuous state of outbreak. The more recent trend suggested that COVID-19 was endemic in the region and no longer reached the threshold of the pandemic definition. However, several countries remained in a state of outbreak, and the conclusion that COVID-19 was no longer a pandemic in Europe at the time is unclear.
Flexibilidad cognitiva y rendimiento académico en estudiantes de primer año de medicina
Authors: Jaimes Medrano Aurora Leonila , Fossion Ruben , Flores Lázaro Julio , Caraveo-Anduaga Jorge Javier
Published: October 2023

Introducción: Diversas investigaciones han demostrado que la flexibilidad cognitiva predice el rendimiento académico, principalmente en escolares, pero solo unas pocas han demostrado la participación de la flexibilidad cognitiva en el rendimiento académico de estudiantes universitarios.
Objetivo: Analizar la asociación entre la flexibilidad cognitiva y el rendimiento académico de los estudiantes de primer año de medicina; además de algunos antecedentes socioeconómicos que influyen en el desarrollo y en el rendimiento académico.
Método: Se realizó un estudio descriptivo de corte transversal, en una muestra de 406 estudiantes de primer año de medicina, se evaluó la flexibilidad cognitiva (con el programa informático WisConPC) y los antecedentes socioeconómicos, como factores asociados al rendimiento académico de estudiantes de medicina mediante un análisis de regresión lineal múltiple.
Resultados: El estudio muestra que la flexibilidad cognitiva y el contexto sociocultural son factores asociados al rendimiento académico general, particularmente en materias biomédicas.
Conclusiones: Los hallazgos de este estudio tienen implicaciones para el proceso de enseñanza-aprendizaje de las ciencias biológicas y químicas, ya que los docentes pueden promover la flexibilidad cognitiva utilizando estrategias didácticas dirigidas al desarrollo y uso de operaciones mentales que implican la formulación de inferencias y la aplicación de ecuaciones proporcionales, razonamiento lógico y probabilístico, contribuyendo así a la construcción y transformación del conocimiento de los estudiantes.
Kualitas Starter Sourdough dengan Penambahan Sari Salak
Authors: Nataresa I Wayan Bayu Banen , Kuntariati Utik
Published: October 2023

Starter sourdough adalah salah satu olahan ragi alami yang dibuat dari produk tepung, dan air. Penelitian bertujuan guna memahami kualitas starter sourdough dengan penambahan sari salak. Metode penelitian yang dipergunakan dalam penelitian yaitu metode penelitian kuantitatif, kualitatif dengan jenis penelitian eksperimental dan teknik pengumpulan data yang dilakukan secara observasi juga kuesioner. Dalam menentukan kualitas dari starter sourdough dengan penambahan sari salak dinilai dengan menggunakan teknik uji organoleptik yang diujikan kepada 30 responden yang mendapatkan hasil penelitian bahwa starter sourdough dengan penambahan 100% sari salak (P1) memiliki kualitas keunggulan dibagian tekstur yang sangat lembut. Dalam aspek rasa dan aroma, sourdough dengan penambahan sari salak atau tanpa penambahan sari salak memiliki keunggulannya masing masing dari setiap responden.
 
Starter sourdough is one of the natural yeast preparations made from flour and water products. The purpose of this study was to determine the quality of starter sourdough with the addition of snakefruit juice. The research method applied in this study is a qualitative, quantitative research method with the type of experimental research and data collection techniques carried out by observation as well as questionnaires. In determining the quality of starter sourdough with the addition of snakefruit juice, it was assessed using an organoleptic test technique that was tested on 30 respondents who got the results that sourdough starter with the addition of 100% salak juice (P1) had superior quality in the very soft texture. In terms of taste and aroma, sourdough with the addition of snakefruit juice or without the addition of salak juice has its own advantages from each respondent.
Pengaruh Kepemimpinan dan Motivasi Kerja Terhadap Kinerja Karyawan
Authors: Kosala I Ketut Hery , Pantiyasa I Wayan , Wijaya Nyoman Surya
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan dan motivasi kerja terhadap kinerja karyawan. Penelitian ini dilakukan pada The Pond Restaurant Discovery Kartika Plaza Hotel. Populasi yang digunakan dalam penelitian ini adalah 40 orang karyawan dengan seluruh populasi digunakan menjadi sampel. Teknik analisis data yang digunakan adalah analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa kepemimpinan dan motivasi kerja secara bersama – sama berpengaruh terhadap kinerja karyawan adalah, hal ini diperoleh dari nilai signifikansi F sebesar 0,000. Kepemimpinan terhadap kinerja karyawan adalah pengaruh yang positif, hal ini diperoleh dari nilai signifikansi sebesar 0,008. Pengaruh motivasi kerja terhadap kinerja karyawan adalah pengaruh yang positif, hal ini diperoleh dari nilai signifikansi sebesar 0,000. Berdasarkan hasil analisis data menunjukan bahwa besarnya pengaruh kepemimpinan dan motivasi kerja terhadap kinerja karyawan sebesar 84,3%, sementara sisanya sejumlah 15,7% dipengaruhi oleh faktor – faktor lain diluar penelitian ini.
 
This study aims to determine the influence of leadership and motivation work on employee performance. This research was conducted at The Pond Restaurant Discovery Kartika Plaza Hotel. The population used in this study was 40 employees with the entire population used as a sample. Data analysis technique used is multiple linear regression analysis. The research results show that leadership and work motivation jointly influence performance employees is, this is obtained from the significance value of F of 0.000. Leadership on employee performance is a positive influence, this is obtained from the value a significance of 0.008. The effect of work motivation on employee performance is positive influence, this is obtained from a significance value of 0.000. Based on the results of data analysis show that the magnitude of the influence of leadership and work motivation on employee performance by 84.3%, while the remaining 15.7% is affected by other factors outside of this study.
Pengaruh Pelatihan dan Disiplin Kerja Terhadap Kinerja Karyawan
Authors: Parta I Ketut Wira , Ismail Deden , Wijaya Nyoman Surya
Published: October 2023

Penelitian ini bertujuan untuk mengetahui apakah Pelatihan (X1) dan Disiplin Kerja (X2) mempengaruhi Kinerja Karyawan (Y) baik secara simultan atau secara parsial di Nandini Jungle Resort & Spa, Payangan Gianyar. Tempat dilaksanakan penelitian ini adalah di Nandini Jungle Resort & Spa, Payangan Gianyar. Waktu penelitian dilaksanakan pada bulan November 2020 – Juli 2021. Populasi dari penelitian ini adalah 44 yang sekaligus dijadikan sampel sehingga menggunakan metode sampel jenuh. Pengumpulan data menggunakan observasi, wawancara, dokumentasi, kuesioner. Jenis penelitian adalah penelitian korelasional. Kemudian dilakukan analisis secara kuantitatif, yang meliputi: uji validitas, uji reliabilitas, analisis regresi linier berganda dan uji asumsi klasik dengan menggunakan SPSS release 25. Uji hipotesis menggunakan uji F dan uji t. Hasil penelitian menunjukkan pelatihan berpengaruh positif dan signifikan (p<0,05) terhadap kinerja karyawan. Disiplin kerja berpengaruh positif dan sangat signifikan (p<0,01) terhadap kinerja karyawan. Kemudian, Pelatihan dan Disiplin Kerja berpengaruh positif dan sangat signifikan (p<0,01) terhadap Kinerja Karyawan.
 
This study aims to determine whether training (X1) and work discipline (X2) affect Employee Performance (Y) either simultaneously or partially at Nandini Jungle Resort & Spa, Payangan Gianyar. The place where this research was carried out was at Nandini Jungle Resort & Spa, Payangan Gianyar. The time of the study was carried out in November 2020 - July 2021. The total population was 44 people which was also used as a sample so that it used the saturated sample method. Collecting data using observation, interview, documentation, questionnaire. This type of research is correlational research. Then a quantitative analysis was carried out, which included: validity test, reliability test, multiple linear regression analysis and classical assumption test using SPSS release 25. Hypothesis test using F test and t test. The results showed that training had a positive and significant effect (p<0.05) on employee performance. Work discipline has a positive and very significant effect (p<0.01) on employee performance. Then, Training and Work Discipline have a positive and very significant effect (p<0.01) on Employee Performance.
Kreasi Bolu dengan Ketan Kukus
Authors: Susanto Steve , Mahendra I Wayan Eka
Published: October 2023

Ketan merupakan bahan dasar berbagai olahan makanan tradisional khas Indonesia, yang sudah tidak asing bagi masyarakat Indonesia. Ketan biasanya dijadikan suatu suguhan makanan pada tamu yang berkunjung, begitu pula dengan bolu kukus. Bolu kukus merupakan salah satu resep makanan tradisional, dimana pada saat ini masih digemari oleh banyak orang. Tujuan dari penelitian kreasi ketan bolu kukus adalah untuk mengetahui kualitas penggabungan dua makanan yaitu ketan dengan bolu kukus yang akan dilihat dari segi rasa, aroma, tekstur dan warna, kemudian untuk mengetahui daya tahan serta menganalisis seberapa besar biaya yang diperlukan dalam pembuatan kreasi ketan dengan bolu kukus. Pendekatan penelitian yang digunakan adalah penelitian eksperimen, penelitian eksperimen ini dilakukan dengan membuat kreasi ketan bolu kukus, kemudian diuji oleh 20 panelis dengan kuesioner tes uji organoleptik, dan analisis biaya. Hasil penelitian ini berupa kualitas dari kreasi ketan bolu kukus, mendapat nilai yang sedang. Dapat dilihat dari segi rasa mendapat nilai enak, segi aroma harum, segi tekstur cukup lembut, serta dari segi penampilan menarik. Dari hasil uji daya tahan kreasi ketan bolu kukus, mampu bertahan selama 5 hari. Dari hasil analisis biaya dalam pembuatan kreasi ketan bolu kukus membutuhkan biaya Rp. 17.470,00 setiap loyang. Selain itu, perlu dilakukannya penelitian lebih lanjut untuk mengetahui kandungan gizi dari penggabungan ketan dengan bolu kukus tersebut.
 
Sticky rice is the basic ingredient of various traditional Indonesian food, which are already familiar for Indonesian people. Sticky rice is usually used as a food of treat for guest who visiting, as well as steamed sponge cake. Steamed sponge is one of the traditional food recipes, which at this time is still favored by many people. The purpose of the research form creation sponge with steam sticky rice is to determine the quality of combining two foods, namely sticky rice with steamed sponge which will be seen in terms of taste, flavour, texture and color, then to determine the durability and analyze how much cost is required for making creation of sponge with steam sticky rice. The research approach used is experimental research, this experimental research was conducted by making sponge and steamed sticky rice, then tested by 20 panelists with organoleptic test questionnaires, and cost analysis. The results for this study from quality of creations sponge with steamed sticky rice, got medium score. It can be seen in terms of taste, it gets good value, in terms of fragrant flavor, in terms of texture, it is quite soft, and in terms of attractive appearance. From the results of the durability test of steamed sticky rice cake creations, it was able to last for 5 days. And the results of the cost analysis in making creation sponge with steam sticky rice, it costs Rp. 17,470.00 every pan. In addition, further research is needed to determine the nutritional content of combining sticky rice with the steamed sponge.
Evaluation of hematologic inflammatory markers in Graves’ disease
Authors: ATLI Hasan , DAYANAN Ramazan
Published: October 2023

Introduction: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) have been used as new inflammatory markers in certain autoimmune diseases to assess the severity of inflammation. The current study aimed to evaluate the changes in neutrophil and lymphocyte series in hyperthyroid patients and to investigate whether NLR, PLR, and SII may be markers of inflammation.
Methods: This cross-sectional study was conducted with 207 Graves’ patients and 120 healthy controls between 2018-2022 years. Hematologic parameters, thyroid function tests, age and gender were recorded. The NLR, PLR and SII values of all subjects were calculated. Firstly, groups were composed as Graves' group and participants without thyroid disorder as control group. Secondly, Graves' patients composed as two groups before treatment and after antithyroid treatment. These groups were compared with each other in terms of descriptive data and hematological parameters.
Results: The patient and control groups were similar in terms of gender (p=0.522) and age (p=0.051). Graves’ patients had a significantly lower NLR than the control group (p=0.004). There was no significant difference between the groups in terms of PLR (p=0.120) and SII (p=0.577). Patients’ baseline TSH-receptor antibodies (TRAb) levels had a significant positive correlation with fT3 (r:0.283, p<0.001), fT4 (r:0.252, p<0.001) and Thyroid stimulating immunoglobulin (TSI) (r:0.673, p<0.001). There was no significant correlation between TRAb and TSI levels, inflammatory markers, and hematological parameters.
Conclusions: Graves’ patients had lower NLR compared to the control group. The patient and control groups did not have a significant difference with regard to PLR and SII. Thyroid autoantibody levels and inflammatory markers did not have a significant correlation.
Keywords: Hyperthyroidism, inflammation, neutrophils, lymphocytes
Tercerización de servicios de tecnologías de información: modelo de gobierno para las universidades públicas
Authors: Sanguino Reyes Magreth Rossio , Cuesta Quintero Byron
Published: October 2023

Objetivo: El objetivo de esta investigación fue diseñar un modelo de gobierno para la tercerización de servicios de tecnología de la información (TI) en las universidades públicas.
Diseño/metodología: Se empleó una metodología de tipo cualitativa, desarrollada en tres momentos: el primero, consistió en una revisión de estándares internacionales asociados a la gestión de TI y la gestión de proyectos; el segundo, permitió realizar una revisión bibliográfica para definir el estado del arte de la tercerización de TI en las universidades; el tercero, se materializó con el diagnóstico realizado a las universidades públicas de Norte de Santander en relación con la tercerización de sus servicios de TI. Las universidades objeto de estudio fueron: la Universidad de Pamplona y la Universidad Francisco de Paula Santander (sede Central y seccional Ocaña).
Resultados: El modelo propuesto tuvo un enfoque por capas asociadas a los procesos de las universidades (misionales, de apoyo, estratégicos); además, se organizó en seis etapas que se analizaron desde dos perspectivas: la coherencia vertical, que incluyó actividades de gestión y de gobierno para los actores involucrados; y la coherencia horizontal, que permitió que dichas actividades se asociaran a metas específicas y artefactos de ejecución y seguimiento.
Conclusiones: De esta investigación se concluye que, aunque la tercerización es un aspecto relevante en la gestión empresarial, las universidades públicas todavía requieren control sobre las actividades, tanto del lado del cliente, como del proveedor. Por esto, el modelo propuesto establece actividades concretas para los dos actores mediante la gestión conjunta de las responsabilidades en todos los niveles organizativos.
Originalidad: Esta investigación contribuye con el mejoramiento de los procesos en las universidades públicas, puesto que el modelo mitiga los riesgos asociados a estos con la formalización de las actividades, la generación de entregables, el establecimiento de indicadores de desempeño y la asignación de responsabilidades en todos los niveles organizativos.
Determinants of employees’ turnover intention
Authors: AlKandari Ibrahim , Alsaeed Farah , Al-Kandari Anwaar , Alsaber Ahmad , Ullah Karim , Hamza Khadija , Alqatan Ahmad
Published: October 2023

The growing competition for talent and increasing employee turnover intention pose challenges for organizations. This paper examines the effect of employees’ organizational trust, job satisfaction, and perception of organizational performance on intention to leave. The research method used was an online survey, with partial least square structural equation modeling (PLS-SEM). The findings reveal there is an insignificant direct influence of employee organizational trust on turnover intention. Moreover, the impact of job satisfaction and organizational performance on turnover intention was found to be both positive and significant. This paper, therefore, introduces fresh empirical evidence and perspective to augment the body of research on the turnover intentions of employees working at public sector institutions, particularly in the post-COVID-19 context.
Large-scale breeding applications of UAS enabled genomic prediction
Authors: Herr Andrew , Schmuker Peter , Carter Arron H.
Published: October 2023

Breeding for improved, reliable cultivars despite growing environment
irregularity can be challenging. Unmanned aircraft systems (UAS) are a
popular high-throughput phenotyping technology that has been shown to
help understand the mechanisms associated with crop productivity and
create a potential for improved breeding strategy by providing unique
insight into environmental response and cultivar productivity. Spectral
reflectance indices (SRI), including both vegetation and water indices
like NDVI, NDRE, and NWI were used to evaluate 11,593 Washington State
University winter wheat breeding plots between 2019 and 2022. SRIs were
then used with genomic data in univariate and multivariate gBLUP model
predictions for grain yield. Prediction accuracy was evaluated on a
leave-one-year-out validation strategy. Including SRI data as fixed
effects in univariate genomic prediction models can improve prediction
accuracy over the control but is unreliable across years. When used in
multivariate models, SRIs improve prediction performance across years
but minimally when considering the computationally more efficient base
model. In univariate models, when test year NDVI data was used to
calculate breeding values, prediction performance was at least 16%
better than the control, ranging in prediction accuracy from 0.54 in
2019 to 0.93 in 2020. This study highlights the limitations of SRI and
its use in genomic selection, especially when dealing with large
breeding populations across environmental extremes. A significant
application for the technology can be found in early season UAS data
collection to aid accurate predictions in late season, a helpful tool in
tight turnaround times commonly experienced in winter crop breeding
programs.
Utilizing high throughput phenotyping to evaluate and demonstrate herbicide and adjuvant efficacy
Authors: Buescher Elizabeth , Hoerning Cody , Kosnicki Kassi , Jones Marcus
Published: October 2023

High throughput phenotyping has wide applications to evaluate genetic
traits, plant growth and development in different biotic and abiotic
stress environments, as well as under different agriculture management
strategies. Additionally, understanding product efficacy and identifying
the mode of action prior to field testing would improve product pipeline
development for agriculture manufacturers and distributors. WinField
United is using multispectral imaging in different stress conditions
within a controlled environment setting to evaluate product
effectiveness. We have evaluated pesticide product efficacy in the
presence and absence of adjuvants. Adjuvants are materials added to a
pesticide to enhance performance by improving absorption, spreading,
sticking, and penetration properties of the pesticide’s active
ingredient(s). We have measured a statistically significant increase in
pesticide efficacy with the addition of an adjuvant in multiple,
independent case studies showing the increased plant health benefit. In
one study, we observed a 31% decrease in diseased oat plant tissue
[when defined as pixels with Normalized Difference Vegetation Index
(NDVI) value <0.3] when an adjuvant was added to a
commercial fungicide compared to the untreated control and a 23%
improvement when compared to the fungicide alone. Multispectral imaging
has also allowed us to build interactive, 3-D models that demonstrate
product coverage and penetration. Combining quantitative measurements
with interactive, illustrative models, we can more effectively
communicate product efficacy results to retail owners and growers.
Future directions include evaluating biological product efficacy in
which more nuanced plant responses are observed in biotic and abiotic
stress environments.
Ensino a distância 2023
Authors: Rybalko Andrii , Kochetkova Iryna , Kin Olena , Liulchak Svitlana , Khmil Nataliia
Published: October 2023

O presente artigo proporciona uma análise abrangente das pesquisas mais recentes no domínio da educação a distância, abordando os elementos cruciais das tendências, desafios e questões associadas ao ensino remoto. Destacam-se o papel e a relevância das tecnologias contemporâneas no aprimoramento da qualidade do ensino remoto. A metodologia empregada envolve a análise de pesquisas científicas. Com base na revisão da literatura, são examinadas as inovações tecnológicas voltadas para o aperfeiçoamento do processo de aprendizado. Ademais, ressalta-se a importância da interação dinâmica entre professores e alunos no contexto virtual. As conclusões destacam a imperatividade de futuras pesquisas com vistas ao aperfeiçoamento contínuo da educação a distância e do processo de aprendizado. A análise deste artigo oferece um discernimento profundo sobre os desafios contemporâneos e as perspectivas relativas ao avanço da educação à distância.
Technology and Evidence in Non-Big 4 Assurance Engagements: Insights from the COVID-19 Pandemic
Authors: Altiero Elizabeth C. , Baudot Lisa , Hazgui Mouna
Published: October 2023

We interviewed 30 assurance professionals in the United States regarding how and to what extent non-Big 4 firms incorporated technologies into assurance engagements during the COVID-19 pandemic. Informed by technology acceptance models, our findings show that the pandemic played an accelerator role, prompting an open attitude toward experimenting with technologies in assurance engagements. This experimentation increased perceptions of the usefulness of technology in engagement efficiency, given easier and faster evidence gathering. However, the readiness and security of clients’ systems remain barriers in evidence gathering. Assurance professionals perceive technology as useful in producing better quality evidence evaluation, with usage stymied by challenges related to source data integrity, naive use of tools, and distrust of outputs limiting the extent of change in evidence evaluation. Our study indicates more modest technology gains in evidence evaluation than in evidence gathering during the pandemic due to barriers with higher stakes, often tied to assurance conclusions.