bluuebunny/crossref_metadata_2025 huggingface dataset:
LEXICO-GRAMMATICAL FEATURES OF TRANSLATING ENGLISH-LANGUAGE JUDGMENTS OF THE EUROPEAN COURT OF HUMAN RIGHTS INTO UKRAINIAN
Authors: Zinchenko Hanna
Published: January 2025

The article is dedicated to the lexico-grammatical features of translating English-language decisions of the European Court of Human Rights (ECHR) into Ukrainian. The main goal of the research is to identify lexical and grammatical differences in the texts of ECHR judgments and to understand how these features are reflected in translation. The author emphasizes the importance of accurately conveying the originality of the ECHR judgments to ensure access to justice and the effective use of European legal practice by national courts. Incorrect or inaccurate translation can lead to violations of fundamental principles of justice. Moreover, ECHR judgments constitute a distinct genre of legal texts with inherent compositional and linguistic characteristics. They are marked by emotional neutrality, impartiality, and precision of expression, achieved through the use of specialized vocabulary and complex grammatical constructions. ECHR judgments are characterized by a saturation of legal terms and specific vocabulary. The author highlights that many commonly used words acquire special meanings in the context of legal documents. These texts also often contain abbreviations and Latin expressions that require accurate reproduction in translation. Legal clichés and set phrases, which have their corresponding formal Ukrainian equivalents, are frequently encountered in court decisions. Grammatical features of ECHR judgments include the use of complex sentences with numerous subordinate and main clauses, as well as modal verbs expressing obligation or command. Repetition of the same words or phrases, unacceptable in literary style, is typical for legal texts. In conclusion, the author stresses the necessity of considering the lexico-grammatical features of ECHR judgments to ensure high-quality and accurate translation. This article makes a valuable contribution to the field of legal translation by providing an in-depth analysis of the lexico-grammatical characteristics of ECHR judgments.
Divulgação dos Desafios e Oportunidades Ambientais, Sociais e de Governança (ASG) de empresas do Setor Sucroenergético Brasileiro
Authors: Bevilaqua Isabelle Caroline , Neumann Marguit
Published: January 2025

O objetivo do estudo consistiu em analisar a divulgação dos desafios e identificar as oportunidades Ambientais, Sociais e de Governança, em empresas do setor sucroenergético brasileiro. Para tanto, adotou-se uma metodologia qualitativa, com análise de conteúdo nos Relatórios de Safra Anual ou de Sustentabilidade das companhias Atvos, Raízen, Jalles Machado e Grupo Tereos referente as informações da safra de 2021-2022. Foram analisados onze desafios e treze oportunidades setoriais. Para desafios destacou-se: no contexto Ambiental: ênfase em ações que minimizam o impacto na biodiversidade, reaproveitamento de resíduos e de água, rotação de cultura, colheita mecanizada e preocupação com as mudanças climáticas e com as possibilidades ecológicas para destinação da vinhaça; no contexto Social: ações relacionadas aos colaboradores como treinamentos e vinculação de remuneração variável, além da preocupação com a comunidade, a partir da adoção de ações voltadas para o desenvolvimento econômico e social e a busca de soluções para reduzir a vulnerabilidade e; no contexto Governança: ênfase no fortalecimento da cultura empresarial e na diversidade; divulgação da estrutura de governança; e relevância da gestão de riscos. Para as oportunidades setoriais destacou-se: ações ambientais, economia circular, energia, colaboradores, certificações, diversidade, finanças sustentáveis, inovação, logística, novos produtos, padrões, parcerias estratégicas e relacionamento com os stakeholders, sendo que cada oportunidade identificada apresentou ações adotadas pelas organizações que podem ser replicadas por companhias do setor sucroenergético brasileiro. A partir da análise dos desafios e identificação das oportunidades no contexto Ambiental, Social e de Governança, a pesquisa contribui com o setor sucroenergético brasileiro, evidenciando as práticas adotadas pelas companhias analisadas, as quais podem ser aplicáveis ou servir como benchmarking para outras organizações.
POST EXTRACTION COMPLICATIONS AND MANAGEMENT- KNOWLEDGE BASED STUDY AMONG UNDERGRADUATE DENTAL STUDENTS IN KHAMMAM, TELANGANA
Authors:   Student (BDS), Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Anjum Patan , Pratap K.V.N.R. ,   Professor & HOD, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Madhavi Padma T. ,   Professor, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Siva Kalyan V. ,   Reader, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Srujan Kumar V. ,   Senior Lecturer, Department of Public Health Dentistry, Mamata Dental College, Khammam, India.
Published: January 2025

Background: Complications following exodontia is not always avoidable. So, dentists should be aware about the treatment to manage complications following exodontia. Hence, it is necessary to ascertain dental students knowledge and attitude towards post extraction complications and its management.

Aim: To assess the knowledge regarding post extraction complications and its management among dental students in Khammam, Telangana.

Material and Method: Among 150 undergraduate (clinical) students a cross-sectional questionnaire survey was conducted in a tertiary care teaching dental hospital. The sample consists of 87 final years and 63 interns. They were asked to fill a questionnaire which was sent to their mobiles through google link which consists of 20 questions regarding knowledge and attitude about post extraction complications.

Result and Conclusion: Majority of dental students have good quality of knowledge towards post extraction complications. Both the final years and interns have almost equal knowledge regarding post extraction complications. Although dental students have good quality of knowledge towards post extraction complications it is not adequate to manage some rare complications. So, there it is necessary to upgrade their knowledge. The need for this study is if the complications of post extractions are not treated properly it might lead to furthermorelife-threatening complications such as morbidity and death. So it is important for a dental to have an adequate idea and knowledge regarding post extraction complications including some rare complications along with its management.
IS MUCORMYCOSIS A LIFE THREATENING FATAL DISEASE?
Authors:   Student (BDS), Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Anjum Patan , Pratap K.V.N.R. ,   Professor & HOD, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Madhavi Padma T. ,   Professor, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Siva Kalyan V. ,   Reader, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Srujan Kumar V. ,   Senior Lecturer, Department of Public Health Dentistry, Mamata Dental College, Khammam, India.
Published: January 2025

Background: The Covid-19 disease which has lead to panic in many countries including India, and now there is emergence of third wave in many parts of the world. As there are no proper treatment options and remedies for this deadly disease, it is leading to secondary infection among the patients who are Immuno-compromised called Mucormycosis also known as Black fungus disease. Thus it is very much important for the frontline workers to have the knowledge regarding this deadful disease. The objective of the study is to assess knowledge of dental students regarding mucormycosis.

Material and Method: Among 250 dental students a cross-sectional questionnaire survey was conducted in Khammam, Telangana. The sample consists of 79 (3rd years), 78 (4th years), 63 (interns), 30 (Postgraduates). They were asked to fill a questionnaire which was sent to them through google link which consists of 20 questions related to knowledge about mucormycosis.

Result and Conclusion: Majority of dental students were aware of this deadly disease mucormycosis. Almost more than 50% of study sample have knowledge regarding mucormycosis. Post graduate students have more knowledge and awareness regarding mucormycosis when compared with 3rd years, 4th years and interns.
Pilonadal disease: Rationale for the original method of radical surgery
Authors: Sergatskiy K. I. , Aljabr M. , Nikolskiy V. I. , Romanova V. S.
Published: January 2025

Introduction. Considering the dissatisfaction with the results of existing methods for treating the pilonadal disease, the search for the most effective methods of radical surgery is currently ongoing.

Aim. To evaluate the feasibility of using in patients with chronic epithelial coccygeal tract an original method of radical treatment, consisting of excision of the substrate of the disease, plastic surgery of the sacrococcygeal fascia and suturing of the soft tissue defect with vertical polyspaste sutures.

Materials and methods. Main group: 34 patients who underwent an original method of radical surgical treatment. Comparison group: 34 patients who underwent traditional radical excision of the disease substrate.

Results. In the main group, less severe pain was recorded (p < 0.05) on days 1–6 after surgery. In terms of the total number of complications, a significant difference in results was demonstrated with a predominance of the indicator in patients in the comparison group (χ2 = 12.324; p = 0.0004). A significant difference (p < 0.05) was also obtained in the healing time of surgical wounds, with the lowest values in patients after the original surgical technique.

Discussion. The study demonstrated an alternative technique, the implementation of which resulted in a significant reduction in the number of wound complications, severity of pain in the intervention area, average wound healing time, and also noted better quality of life indicators compared to patients who underwent traditional surgery.

Conclusions. The implementation of an original method of radical surgical treatment of the epithelial coccygeal tract can reliably reduce the severity of pain on days 1–6 of the postoperative period, reduce the number of early postoperative complications by 38.23%, and also reduce the average wound healing time by 16 days compared with similar indicators after traditional radical excision of the pilonidal sinus.
Extraprostatic Cysts in Dogs – Case Report
Authors: SZCZEPANKIEWICZ BARBARA , PRZĄDKA PRZEMYSŁAW , KUBIAK-NOWAK DOMINIKA , LISZKA BARTŁOMIEJ , BORAWSKI WOJCIECH , JUŹWIAK ŁUKASZ , PASŁAWSKA URSZULA
Published: January 2025

In veterinary practice, prostatic gland disorders are the most common diseases of the reproductive system in males. The article discusses various prostatic gland disorders in dogs, focusing on prostatic cysts. It indicates that the most frequently occurring prostatic disorders are benign hyperplasia and inflammation, while cysts account for about 5% of cases. Diagnosis involves clinical examination, ultrasound and radiographic examination. Treatment of prostatic cysts can be pharmacological, including chemical castration, or surgical, including marsupialization and omentalization. In this paper, the authors report their diagnosis and treatment of extraprostatic cysts in a dog.
In vitro antibacterial activity of garden thyme (Thymus vulgaris L.) extracts against non-tuberculous mycobacteria strains isolated from diseased ornamental fish
Authors: GUZ LESZEK , PUK KRZYSZTOF , PASTUSZKA ANNA
Published: January 2025

This study was carried out to evaluate the antibacterial activity of aqueous and organic extracts of Thymus vulgaris L. (Lamiaceae). The hexan (HEX), ethanol (ETH) and water (WAT) extracts from aerial parts of T. vulgaris exhibited antimicrobial activity against slow growth mycobacteria – SGM (n = 49) and rapid growth mycobacteria – RGM (n = 50) strains isolated from diseased ornamental fish. The MICAV values of HEX, ETH, and WAT extracts against RGM strains were found to be at 146.50 μg/mL, 728.00 μg/mL, and > 800 μg/mL, respectively. The MICAV values of HEX, ETH, and WAT extracts against SGM strains were found to be at 50.77 μg/mL, 253.06 μg/mL, and > 800 μg/mL, respectively. The most active extract against RGM and SGM strains was the hexane extract. Its chemical composition was determined using GC-MS, which allowed the identification of 53 compounds. The major chemical compounds in HEX extracts were found to be thymol (27.35%), tetratetracontane (19.68%), dotriacontane (10.34%), p-cymene (5.92%), stigmast-5-en-3-ol (4.89%), carvacrol (2.64%), thymoquinone (2.00%), (1r)-1,6,6-trimethylcis- bicyclo[3.3.0]octan-3-one (2.52%), 5,10-dihexyl-5,10-dihydro indole[3,2b]indole-2,7-dicarbaldehyde (2.15%), and linalyl anthranilate (1.06%), the proportion of other components being below 1%. In conclusion, among the tested extracts, the HEX extract exhibits the strongest properties against nontuberculosis mycobacteria isolated from diseased ornamental fish.
A Promising Druggable Target for Translational Therapy of Ovarian Cancer: A Molecular Profiling of Therapeutic Innovations, Extracellular Vesicle Acquired Resistance, and Signaling Pathways
Authors: Mustafa Mohd , Abbas Kashif , Ahmad Waleem , Ahmad Rizwan , Islam Sidra , Khan Hamda , . Moinuddin , Hassan Md Imtaiyaz , Parveen Shazia , Habib Safia
Published: January 2025

Ovarian cancer (OC) ranks as the fifth leading cause of cancer-related deaths
in the United States, posing a significant threat to female health. Late-stage diagnoses,
driven by elusive symptoms often masquerading as gastrointestinal issues, contribute to
a concerning 70% of cases being identified in advanced stages. While early-stage OC
brags a 90% cure rate, progression involving pelvic organs or extending beyond the peritoneal
cavity drastically diminishes it. Overcoming chemoresistance and metastasis requires
a deep understanding of the associated progression mechanisms for innovative
therapies. Extracellular vesicles (EVs), containing proteins, RNAs, DNAs, and metabolites,
have surged in recent years, significantly impacting tumor progression, recurrence,
immune evasion, and metastasis associated with the ovarian tumor microenvironment.
Recent research unveils organ-specific metastatic patterns in OC, providing insights into
tumor cell interactions and signaling crosstalk with stromal cells. The review explores
the role of EVs behind OC cell metastasis and chemoresistance. Furthermore, the article
delves into the role of EVs in the tumor microenvironment, immune evasion, and as biomarkers
in context to OC, offering promising therapeutic strategies to enhance survival
rates for OC patients. Lastly, the article focuses on an overview of PI3K/AKT/mTOR,
MAPK/ERK, and VEGFR signaling pathways in the pathophysiology of ovarian cancer.
Computational Model to Predict Potential Therapeutic Targets Employing Generative Adversarial Networks for Analysis of Proteins Involved in Mycobacterium fortuitum Biofilm Formation
Authors: Ghai Shan , Shrivastava Rahul , Jain Shruti
Published: January 2025

A planktonic population of bacteria can form a biofilm by adhesion and colonization.
Proteins known as “adhesins” can bind to certain environmental structures,
such as sugars, which will cause the bacteria to attach to the substrate. Quorum sensing
is used to establish the population is dense enough to form a biofilm. This paper presents
a comprehensive overview of our investigation into these processes, specifically focusing
on Mycobacterium fortuitum, an emerging pathogen of increasing clinical relevance.
In our study, we detailed the methodology employed for the proteomic analysis
of M. fortuitum, as well as our innovative application of Generative Adversarial Networks
(GANs). These advanced computational tools allow us to analyze complex data
sets and identify patterns that might otherwise remain obscured. With a particular focus
on the effectiveness of GAN, the identified proteins and their potential roles in the context
of M. fortuitum's pathogenesis were discussed. The insights gained from this study
can significantly contribute to our understanding of this emerging pathogen and pave the
way for developing targeted interventions, potentially leading to improved diagnostic
tools and more effective therapeutic strategies against M. fortuitum infection. The authors
can achieve 95.43% accuracy for the generator and 87.89% for the discriminator.
The model was validated by considering different Machine learning algorithms, reinforcing
that integrating computational techniques with microbiological investigations can
significantly enhance our understanding of emerging pathogens. Overall, this study emphasizes
the importance of exploring the molecular mechanisms behind biofilm formation
and pathogenicity, providing a foundation for future research that could lead to innovative
solutions in combating infections caused by M. fortuitum and other similar pathogens.
Experimental Evidence of the Benefits of Acupuncture/Electroacupuncture for Acute Lung Injury/ Acute Respiratory Distress Syndrome: A Literature Review of Rodent Studies
Authors: Zeng Lin , Yan Jiangtian
Published: January 2025

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)
encompass various etiologies and are distinguished by the onset of acute pulmonary
inflammation and heightened permeability of the pulmonary vasculature, often leading
to substantial morbidity and frequent mortality. There is a scarcity of viable approaches
for treating effectively. In recent decades, acupuncture has been proven to be antiinflammatory.
This review aims to provide a comprehensive summary of the previously
documented mechanisms underlying the beneficial effects of acupuncture in
ALI/ARDS, including inhibiting excessive oxidative stress, alleviating pulmonary
inflammatory response, suppressing programmed cell death, and protecting the
alveolar-capillary membrane. Collectively, these findings indicate that acupuncture
yields therapeutic benefits for ALI/ARDS.
Cu@DPP-SPION: A Novel and Versatile Catalyst for the Synthesis of Thioxo-Tetrahydropyrimidine Derivatives under Mild Reaction Conditions
Authors: Ghasemi Nastaran , Moradi Shahram , Mahdavi Mohammad , Iraji Aida
Published: January 2025

Introduction:

The development of efficient and sustainable catalytic methodolo-gies has garnered considerable attention in contemporary organic synthesis.

Methods:

Herein, we present a novel approach employing the Cu@DPP-SPION catalyst for the synthesis of ethyl 4-(aryl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives. This versatile catalytic system incorporates copper nanoparticles supported on 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzoic acid-functionalized superparamagnetic iron oxide nanoparticles (SPIONs). The catalyst was meticulously characterized through scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS), and inductively coupled plasma (ICP) analysis. The catalytic process, exemplified by the synthesis of heterocyclic compounds, demonstrated high isolated yields, attesting to the robust performance of the catalyst.

Results:

Furthermore, the reusability of the catalyst was validated through five consecutive reactions without a notable decrease in yield, while structural stability was confirmed by SEM analysis. The methodology combines green reaction conditions, room temperature operation, and facile magnetic catalyst separation, underscoring its potential for sustainable synthesis.

Conclusion:

This work highlights the promise of the Cu@DPP-SPION catalyst as an innova-tive tool in heterogeneous catalysis and its role in advancing efficient and environmentally conscious synthetic methodologies.
The Causal Effects of Lifestyle Factors on Osteoarthritis: A Two-sample Mendelian Randomisation Study
Authors: Ho Justin , Mak Christopher Chi Hang , Lau Lawrence Chun Man , To Kendrick , Khan Wasim
Published: January 2025

Background:

Modern sedentary lifestyles are prevalent among individuals with osteoarthritis.
However, direct evidence linking such behaviours as causative factors of osteoarthritis
remain limited due to the presence of confounding variables.

Objective:

This study aims to determine the extent to which lifestyle factors have causal effects on
osteoarthritis through a two-sample Mendelian randomisation (MR) study.

Methods:

Exposure-outcome relationships were evaluated using inverse variance weighted twosample
MR and summary statistics of genome-wide association studies of lifestyle factors and osteoarthritis.
Weighted median, MR-PRESSO, and MR-Egger regression were used as sensitivity
analyses. We obtained causality estimates, 95% confidence intervals (CI), and P-values from each
MR method. Steiger filtering and radial filtering were used to exclude SNPs demonstrating reverse
causality and significant heterogeneity, respectively.

Results:

MR analyses demonstrated that certain lifestyle factors had causal effects on osteoarthritis,
particularly insomnia (OR 1.09 (0.387-1.79), P = 0.0024), BMI (OR 6.45 (4.48-8.42), P =
1.38e-10) and protein intake (OR 2.94 (0.361-5.52), P = 0.026). Effects were consistent across sensitivity
analyses using median-based MR methods. ZNF131 & SEMA3F, and potentially RWDD2B
& USP8 are genetic loci identified to mediate these causal effects.

Conclusion:

Our results illustrate that lifetime exposure to certain lifestyle factors has causal effects
on osteoarthritis. Further studies are required to determine the efficacy of lifestyle-based interventions
in reducing the population-wide disease burden of osteoarthritis.
Maternal and Perinatal Outcome in Acute Fatty Liver of Pregnancy
Authors: Karnamadakala Shubhada , K Shraddha Shetty , Shetty Suprajna
Published: January 2025

Background:

Acute Fatty Liver of Pregnancy (AFLP) is a rare obstetric condition that
can lead to maternal and perinatal complications.

Aim and Objectives:

This study aimed to study the pregnancy outcome in Acute fatty liver of Pregnancy
(AFLP). In particular, this study aimed to study the clinical features of the condition and its
effect on maternal and perinatal outcomes.

Materials and Methods:

A retrospective analysis of seven cases diagnosed with AFLP over a span
of three years was performed. The clinical records of these women were reviewed for clinical features,
laboratory investigations, and maternal and perinatal outcomes.

Results:

The incidence of AFLP was 4/10,000 births. A total of 6(85.7%) women presented during
the third trimester of pregnancy. A total of 4(57%) of them presented after 36 weeks of gestation. A
total of 6(85.7%) women presented with jaundice, and all presented with sudden onset nonspecific
symptoms, including abdominal pain and vomiting. Pregnancy was terminated by cesarean section
in 6 cases. Maternal mortality was noted in 6(85.7%) of women. All six women were diagnosed
with Acute kidney injury and coagulopathy. One woman had developed encephalopathy and altered
sensorium. Further, 2(28.5%) women had intrauterine fetal demise at the time of presentation, and
1(14.3%) had an early neonatal death.

Conclusion:

AFLP is a rare clinical syndrome with rapid and dramatic progression, beginning initially
with non-specific symptoms and evolving into coagulopathy, acute kidney injury, and death,
resulting in alarming maternal and perinatal mortality. Early diagnosis is challenging due to the
non-specificity of symptoms, but crucial and prompt termination of pregnancy is the need of the
hour. Nonetheless, supportive treatment and a multidisciplinary approach may significantly improve
prognosis.
DWI-Derived Sequences: Application in the Evaluation of Liver Fibrosis
Authors: Tian Lei , Liu Sibin , Zhou Han , Wu Yiting
Published: January 2025

There exists a close relationship between liver fibrosis and Hepatocellular Carcinoma (HCC). Prolonged progression of liver fibrosis may
ultimately lead to cirrhosis, thereby increasing the risk of developing HCC. Current research is exploring non-invasive methods for assessing liver
fibrosis. One such method is the single exponential model Diffusion-weighted Imaging (DWI) sequence, which uses the Apparent Diffusion
Coefficient (ADC) to quantify tissue characteristics. However, this method has limitations when it comes to evaluating the degree of liver fibrosis.
Intravoxel Incoherent Motion (IVIM), Diffusion Kurtosis Imaging (DKI), Stretched Exponential Model (SEM), and Fractional Order Calculus
(FROC) have been developed based on traditional single-exponential DWI. These advancements have made diffusion-weighted imaging more
specific. However, their imaging principles and application values differ. This article aimed to review the research progress of these DWI-derived
sequences in the evaluation of liver fibrosis.
White Matter Fiber Bundle Alterations Correlate with Gait and Cognitive
Impairments in Parkinson’s Disease based on HARDI Data
Authors: Dong Lining , Zhang Mingkai , Wang Zheng , Yan Ying , An Ran , Wang Zhenchang , Wei Xuan
Published: January 2025

Background:

The neuroanatomical basis of white matter fiber tracts in gait impairments in individuals suffering from Parkinson’s Disease (PD) is unclear.

Methods:

Twenty-four individuals living with PD and 29 Healthy Controls (HCs) were included. For each participant, two-shell High Angular Resolution
Diffusion Imaging (HARDI) and high-resolution 3D structural images were acquired using the 3T MRI. Diffusion-weighted data preprocessing
was performed using the orientation distribution function to trace the main fiber tracts in PD individuals. Clinical characteristics between the two
groups were compared, and the correlation between the FA value and behavioral data was analyzed. Quantitative gait and clinical parameters were
recorded in PD at ON and OFF states, respectively.

Results:

The mean tract-specific FA values of the right Cingulum Cingulate (rCC) were statistically different between the PD group and the HC group (p
=0.047). The FA value of 34-58 equidistant nodes in rCC was positively correlated with Mini-Mental State Examination (MMSE) (r=0.527,
p=0.024), Berg Balance Scale (BBS)-OFF (r=0.480, p =0.040), and BBS-ON (r=0.528, p =0.024) scores, while it was negatively correlated with
the MDS-UPDRS-III-ON score (r=-0.502, p =0.030). Regarding the gait analysis, the FA value was significantly correlated with velocity, cadence,
and stride time of the pace and rhythm domains in both ‘ON’ and ‘OFF’ states, respectively (p<0.05).

Conclusion:

This study served as an initial exploration to establish that HARDI sequences could be employed as a robust tool for analyzing microstructural
alterations in white matter fiber bundles among PD patients, although the sample size was small. We confirmed microstructural integrity
impairment of rCC to be significantly associated with both gait and cognitive deficits in patients with PD. Early detection of microstructural
changes in rCC and targeted treatment can help improve behavioral disorders. In the future, we intend to further integrate multimodal data with
assessments of patient behavior both prior to and following intervention. We will validate our findings within an independent cohort to monitor
disease progression and evaluate the efficacy of therapeutic interventions.
Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis
Authors: Jin Yuzhao , Liao Luyu , Chen Qianping , Tang Bufu , Jiang Jin , Zhu Ji , Bai Minghua , Guo Lingjiao
Published: January 2025

Background:

Colorectal cancer (CRC) is the third most common cancer worldwide,
and its occurrence and progression are often regulated by genetic and hereditary factors. Ubiquitination
and the associated ubiquitin-binding enzymes and ligases regulate the tumor microenvironment
and antitumor immunity to mediate tumor pathogenesis and progression. In this study, we examined
the molecular characteristics and immunomodulatory effects of ubiquitination-associated
genes that mediate CRC prognosis.

Methods:

The ubiquitination-related gene ubiquitin domain-containing protein 1 (UBTD1) was
identified using bioinformatics and single-cell analyses. Subsequently, the ability of UBTD1 to
predict CRC prognosis and immune checkpoint correlation was analyzed, the potential drug telatinib
targeting UBTD1 was explored, and the correlation between UBTD1 and ferroptosis was analyzed.
The role of UBTD1 in CRC and ferroptosis was verified using immunohistochemistry,
gene knockout, western blot, cell cloning, and immunofluorescence.

Results:

UBTD1 was identified as a significant prognostic and predictive gene for CRC and was
involved in regulating immune checkpoint levels and immune cell function of CRC patients with
CRC. High UBTD1 expression was found to enhance the presence of immune checkpoints that induce
immune escape and inhibit ferroptosis onset. Telatinib may be a potential therapeutic drug
targeting UBTD1.

Conclusion:

Our study demonstrated that UBTD1 is a prognostic marker for CRC in the regulation
of ubiquitination and the tumor immune microenvironment and may serve as a modulator of
ferroptosis.
PKE-Ubsite: A Ubiquitylation Site Predictor for Plants Based on Multiple Encoders and Ensemble Deep Learning Framework
Authors: Wang Xin , Zhang Zi Meng , Liu Chang
Published: January 2025

Introduction:

Ubiquitylation, a key post-translational modification [PTM], has significant
influences on the structures, activities, and functions of proteins and is linked to various diseases.
Traditional experimental identification and characterization methods for identifying ubiquitylation
sites [Ubsites] are time-consuming, expensive, and labor-intensive if prior knowledge concerning
ubiquitylation is absent. Nevertheless, most methods reported for predictions of Ubsites are based on
traditional machine learning. Owing to the increased availability of genomic and proteomic samples,
deep learning-based recognition methods for Ubsites are becoming increasingly popular.

Method:

In this study, we propose a new feature extraction method, pKcode, based on only seven
physicochemical features of amino acids [AAs]. The pKcode captures both the biochemical context
and precise sequence locations of AAs around the Ubsites, improving the predictive capability for
ubiquitination. We created the pKPAP encoding scheme by integrating the pKcode with
PSDAAP, AAC, and PWAA, resulting in an all-encompassing feature representation. Concurrently,
we developed the PKE- Ubsite.

Result:

Ubsite model, a new ensemble prediction framework, amalgamates the power of classifiers in
five pipelines: three bidirectional long short-term memory [BiLSTM] networks, one convolutional neural
network [CNN], and one random forest [RF] classifier. Each classifier uses an optimized combination
of encoding features, and an integrated classification is achieved through a voting mechanism.

Conclusion:

Finally, compared with existing models on an independent test set, our model has an accuracy
of 0.8368, an F1-score of 0.8430, a precision of 0.8124, a recall of 0.8760, and an AUC of
0.9103, which are superior to all methods reported to date. Overall, PKE-Ubsite may facilitate a
thorough understanding of ubiquitylation.
Association of Interleukin-4 Receptor α Chain I50V Gene Variant (rs1805010) and Asthma in Iranian Population: A Case-control Study
Authors: Mowahedi Masouma , Aramesh Azam , Khouzani Mozhgan Sorkhi , Khouzani Marjan Sorkhi , Daryanoush Saeed , Samet Mohammad , Samadi Morteza
Published: January 2025

Background

Asthma is one of the respiratory disorders caused by chronic airway inflammation. IL-4 has been identified as one of the participating interleukins in the severity of asthma.

Objective

A case-control study was conducted to determine the association of rs1805010, a single nucleotide polymorphism in the interleukin 4 receptor α chain, with asthma and immunoglobulin E and IL-17A serum levels in Iranian populations.

Methods

ELISA was used to investigate the relationship between three different varieties of SNP I50V and serum IL-17A levels, as well as total IgE levels. Based on GINA criteria, patients were classified into mild, moderate, and severe groups based on the association between SNP I50V, IL-17A, and total IgE. In order to analyze the data, the student-t-test and the one-way ANOVA were used.

Results

The SNP I50V was associated with asthma in a significant way (p = 0.001). IL-17A and total IgE levels were significantly higher in asthmatic patients than in control participants (p 0.05 and p 0.021, respectively), but neither showed any association with SNP I50V in the asthmatic patients.

Conclusion

Asthma patients have a higher prevalence of the I allele, reflecting the significance of Th2 cells. Although total IgE and IL-17A levels increased in both disease subgroups, total IgE level augmentation correlates directly with disease severity, while IL-17A level enhancement does not.
Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines Reviewed
Authors: Sharma Munish , Joshi Sushil , Banjade Prakash , Ghamande Shekhar A , Surani Salim
Published: January 2025

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report is an essential resource for all clinicians who strive to provide optimal care to patients with chronic obstructive lung disease (COPD).
The annual report of GOLD makes few revisions and updates besides including data from the preceding year. At an interval, GOLD comes up with a significant modification in its guidelines, which is generally a major overhaul of the pre-existing guidelines. According to the latest 2023 updates, published in November 2022, there have been significant advancements made in the field of COPD. These include the development of more precise definitions for COPD and its exacerbations, the introduction of a new set of parameters to measure exacerbation severity, and updating the COPD assessment tool. Additionally, revisions have been made to the initial and follow-up treatment guidelines. The report also simplifies the treatment algorithm and sheds light on new findings that suggest the use of pharmacological triple therapy can reduce mortality rates. Furthermore, the report includes discussions on inhaler device selection and adherence to COPD medications. These improvements demonstrate a continued effort to enhance COPD treatment and management. Although there are some areas that could benefit from more detailed guidance and explanation, such as the proper utilization of blood eosinophil counts for treatment decisions, and the establishment of treatment protocols post-hospitalization, the latest modifications to the GOLD recommendations will undoubtedly aid healthcare providers in addressing any gaps in patient care. We aim to highlight key changes in the GOLD 2023 report and present a viewpoint about their potential implications in a real-world clinical scenario.
Indigenous Placenta Disposal: The Views of Midwives and Traditional Birth Attendants/Indigenous Knowledge Holders in Tshwane District, Gauteng Province, South Africa
Authors: Moeti Cecilia , Mulaudzi Fhumulani Mavis , Rasweswe Molatelo Melitah
Published: January 2025

Background

Prior to the development of modern obstetric services, indigenous people had their own ways of disposing placenta, which are still practiced in some communities. However, persistent gaps exist in the South African healthcare system that deals with the integration of indigenous knowledge and Western medical services due to constraints in knowledge and expertise.

Methods

A qualitative approach using explorative design guided by the 5D appreciative inquiry model was employed. The participants were ten midwives, four traditional midwives, and six indigenous knowledge holders, who were recruited through a purposive sampling method. Data were collected through semi-structured individual interviews. Content data analysis was followed.

Results

Knowledge of the indigenous placenta disposal was discovered from the data, although some of the midwives had no idea. It was also discovered that indigenous placenta disposal is regarded as a valuable practice that should be respected, and the legislature on indigenous placenta disposal should be recognised and acknowledged.

Conclusion

The findings have demonstrated the significance of understanding and appreciating the various indigenous placenta disposal methods,and the need to legislate the historical impact on its beliefs and practices. This paper has thus aimed to explore and describe the views of the midwives and traditional birth attendants/indigenous knowledge holders in the Tshwane district, Gauteng province, South Africa.
Improving Antioxidant Effect of Stemona tuberosa by Fermentation with Endophytic Fungus Penicillium expansum STRB13
Authors: Dong Jian-Wei , Li Xue-Jiao , Zhao Hui , Wang Xue-Xian
Published: January 2025

Background:

Stemona tuberosa Lour. is a plant belonging to the genus Stemona
(Stemonaceae) that has been utilized in traditional Chinese medicine (TCM) for its antitussive and
antiparasitic properties. Endophytic fungi have been shown to play an important role in the growth
and metabolism of plants. Fermentation involving endophytic fungi tends to result in the production
of new or more potent pharmacological compounds.

Objective:

The study aims to enhance the antioxidant activity of S. tuberosa by fermenting it with a
symbiotic endophytic fungus.

Methods:

Seven symbiotic endophytic fungi were used to screen and ferment S. tuberosa to improve
antioxidant activity estimated by 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity
and ferric ion-reducing antioxidant power (FRAP). The chemical constituent changes were characterized
by ultraviolet (UV) spectrum and high-performance liquid chromatography (HPLC) analysis.

Results:

Penicillium expansum STRB13, an endophytic fungus associated with S. tuberosa, was
screened for its ability to enhance antioxidant capacity through fermentation. The fermentation of S.
tuberosa using P. expansum STRB13 significantly improved its DPPH radical scavenging activity,
achieving an IC50 value of 24.2 μg/mL. Additionally, the ferric reducing antioxidant power (FRAP)
of the fermented sample was fourteen times greater, measuring 388.1 ± 32.6 μmol/L compared to
27.5 ± 1.0 μmol/L in the blank sample. Differences observed between the blank and P. expansum
STRB13 fermented S. tuberosa (FST) in UV spectra and HPLC analysis indicated the production of
new aromatic phenolic compounds through fermentation, which contributed to the enhanced antioxidant
activity.

Conclusion:

This is the first time reporting on the fermentation processing of S. tuberosa with symbiotic
endophytic fungus. This study revealed that P. expansum STRB13 FST will be an alternative
natural antioxidant. Fermentation with symbiotic endophytic fungus is a new approach to processing
TCM and discovering new compounds.
A Comprehensive Assessment of Various Converter Topologies for Electric Vehicle and Grid Integration
Authors: Sharma Yogendra Kumar , Kidwai Mohd. Suhaib , Husain Mohammed Aslam , Ansari Akhtar Saleem , Kumar Navneet , Bakhsh Farhad Ilahi
Published: January 2025

The emergence of Vehicle-to-Grid technology presents an encouraging frontier, enabling
electric vehicles (EVs) to work as energy resources for various resident appliances, thereby
playing crucial roles in peak load management, power stability, and balancing the load. Vehicleto-
grid hinges on both directions of power flow between the Electric Vehicle batteries and AC
grid, facilitated by converters having bidirectional electronics power. This study undertakes a
comprehensive investigation of various power factor correction (PFC) devices and various converter
(DC to DC) topologies tailored for Vehicle to Grid or Grid to Vehicle operations. A detailed
comparison of THD, efficiency, and power level of various topologies has been presented in
this paper. The observations based on the comparative analysis have also been given. Additionally,
through a detailed analysis, considering factors such as efficiency and THD, this study aims to
guide the selection of suitable bidirectional chargers, thus serving as a valuable resource for decision-
makers in the Electric Vehicle domain.
Wind Power Prediction Based on The SENet-CNN-LSTM Model
Authors: Zhang Zhiyan , Zhang Xuefeng , Li Ke , Li Jianyong , Zhao Hailiang , Liu Hua
Published: January 2025

aims:

To improve the accuracy of wind power prediction

background:

In recent years, wind power has developed rapidly nationwide and worldwide.How to improve the prediction precision and accuracy of wind power has become a research hotspot in this field

objective:

This paper aims to construct a wind power forecasting system based on SENet-CNN-LSTM to improve the accuracy and stability of wind power forecasting

method:

Firstly, the isolated forest algorithm is used to detect abnormal values in wind power historical data, and the linear interpolation method is used to fill in the missing data. Secondly, CNN is used to extract the spatio-temporal characteristics of wind power data, SENet is used to assign different weights to the extracted feature information, and LSTM’s unique gating mechanism is used to memorize and forget the information. Finally, taking the measured historical data of a wind power farm as the sample, six algorithms including CNN, LSTM, CNN-LSTM, SENet-CNN, SENet-LSTM and SENet-CNN-LSTM are used to predict the example

result:

The prediction results show that the RMSE, MAE and MAPE of SENet-CNN-LSTM are significantly reduced compared with the other five prediction models

conclusion:

The wind power prediction model based on SENet-CNN-LSTM has high prediction accuracy and good performance

other:

There is no.
The relationship between career optimism and subjective career success among teachers
Authors: Apriliani Enana , Ingarianti Tri Muji
Published: January 2025

The lack of fulfillment of teachers' rights has resulted in teachers feeling less prosperous and less satisfied with their current careers. In order to feel career satisfaction, teachers need a measure of subjective career success. Achieving subjective career success requires career optimism so that teachers can view their future career positively, focus on developing their potential, and plan their career path. The objective of this study is to determine the relationship between career optimism and the eight dimensions of subjective career success among teachers. The study used quantitative methods and quota sampling techniques with a total of 300 participants. The result of the study showed that career optimism is significantly related with the five dimensions of subjective career success, (i.e., authenticity, growth and development, influence, personal life, and satisfaction). Moreover, career optimism is not significantly related with the three other dimensions of subjective career success (i.e. meaningful work, quality of work, and recognition).
İbnü’l-Arabî’de Kadın Meselesinin Epistemik Çerçevesi: Yetkinleşme-Bireyselleşmenin Zemini Olarak Kadın ve Erkek İlişkisi
Authors: Demirli Ekrem
Published: January 2025

İnsan, bilinebilen tarihinden itibaren kendini düşünme konusu hâline getirmiş, bilgi ve eylem imkânlarıyla birlikte sürekli daha fazlasını merak ederek dünya içindeki var oluşunu güçlendirmek istemiştir. Bu meyanda insan erkek ve kadındır. İnsanlık kadın ve erkek için müşterek kavram olsa bile, insanlar arasındaki çeşitli sorunlar ve ayrışmalar bu kez cinsler arasında da ortaya çıkmış, zaman içinde kadın ve erkek farklı yönleriyle düşüncenin konusunu teşkil etmiştir. Modernleşme ile birlikte kadın daha çok yitirilmiş haklarını elde etmekle ve toplumsal alanda engellenmesine karşı mücadele vermekle modern dünyanın inşasında yerini almaya çalışmışken bu engellenmişliğin tahlili geniş bir tarih ve toplum teorisi içerisinde yapılmak istenmiştir. Hiç kuşkusuz çağımızın hâlihazırda en güncel konularından biri kadındır. Hiçbir dönemde kadın bahsi modern dünyada ele alındığı gibi ele alınmış değildir. Bu yönüyle tarihsel her araştırma belirli ölçüde anakronik olmak durumunda kalacak, metodolojik eksikliklerle malul olacaktır. Bununla birlikte modern çağdaki sorunlara kısmen benzeyebilecek yaklaşımlar sergileyen en müstesna isim Muhyiddin İbnü’l-Arabî (ö. 638/1240) kabul edilebilir. ‘İnsan merkezli’ tasavvuf-metafizik anlayışına sahip İbnü’l-Arabî aynı zamanda erkek ve kadın üzerinde düşünmeyi, düşüncenin temel konularından biri kılmış, metafizik tasavvurunu bu sorunlar üzerinden ortaya koymuştur. Onun düşüncesinde insan ‘dış dünyada delil arayan bir varlık’ olmaktan çıkarak bizzat delil ve burhan hâline gelmiş, böylece metafizik bilgi yön değiştirmiş, erkek ile kadın ilişkisi ise ilk kez metafizik bir muhteva dâhilinde ele alınabilmiştir. Yazının ana fikri bir metafizikçinin düşüncesinde insanı, daha özelde ise onun erkek ve kadın ile ilişkisini tespit etmektir. Bu sayede çağdaş dünyada Müslüman toplumun bakış açısının normatiflikten metafizik olana doğru evrilmesine bir kapı açmak amaçlanmıştır.
Process Relational Theology and Islamic Feminist Thought: An Initial Exploration
Authors: Duderija Adis
Published: January 2025

This article examines the potential contributions of process relational theology to Islamic feminist theology, arguing that such an engagement can significantly enrich existing efforts to reinterpret Islamic tradition through a gender-justice lens. Process relational theology, by emphasising a dynamic, interconnected, and responsive God, offers a fertile framework that challenges traditional hierarchical views of divine-human relationships and gender dynamics found in mainstream Islamic theology that have strong patriarchal tendencies. The article suggests that integrating process thought into Islamic feminism can provide fresh perspectives on key Islamic theological concepts that can further fortify the discursive foundations of Islamic feminist theology. After outlining the history of feminist thought in modern Muslim contexts and reviewing recent contributions to Islamic feminism in the works of Asma Lamrabet, Sa’diyya Shaikh and Jerusha Lamptey Tanner, the article explores how process relational theology’s emphasis on dynamic relationships and rejection of rigid hierarchies can offer new insights into Islamic feminist discourse. This integration aims to develop more gender egalitarian understandings of divine-human relationships, gender dynamics, and religious authority in Islamic theology, potentially expanding the metaphysical and theological foundations of Islamic feminism and Islamic feminist theology and opening new avenues for dialogue.
Kutsallığın İnşasında Kadın ve Öteki Kadın: Sare ve Hacer
Authors: Kaya Cansu
Published: January 2025

Bu çalışmanın amacı Tanah, Kitab-ı Mukaddes ve Kur’an-ı Kerim temelindeki Sare ve Hacer kimliğinin nasıl konumlandırıldığını incelemektir. Bunun için kimliğin temel mantığındaki özne ve öteki ayrımından yola çıkarak, öncelikle üç kutsal kitabın kadın kimliğini nasıl kurguladığına bakılmıştır. Bu çalışmanın bulgularına göre, Tanah’taki kadın kimliği İsrail topraklarına layık olmaya ilişkinken, Kitab-ı Mukaddes’teki kadın kimliği Mesih’e tabi olmaya bağlanmaktadır. Kur’an’da ise kadın kimliği farklı bir formda olup özellikle cariyeler için bildirdiği hükümler, o dönem için özgür kadın kimliğini inşa etme girişimi olarak değerlendirilebilmektedir. Tanah ve Kitab-ı Mukaddes’te kadının özne oluşu Sare’ye (özgür kadına) dayanırken, Hacer köle kadın konumuyla öteki sayılmıştır. Kur’an’da ise böyle bir ayrım yer almamaktadır. Yahudiler ve Hristiyanlar Sare’den doğmayı önemsemiş, özellikle Yahudiler ulusal kimliklerini bu minval üzere inşa etmiştir. Bu makalede üç kutsal kitapta Sare ve Hacer olmanın neye tekabül ettiği ele alınmakta ve bu meselenin süregelen İsrail-Filistin meselesinin anlaşılmasında dikkate değer bir rol oynadığı ileri sürülmektedir.