bluuebunny/crossref_metadata_2025 huggingface dataset:
Students’ Attitude and Motivation in Bilingual Education
Authors: Jurado Beatriz Calderón , Garcia Cristina Morilla
Published: October 2018

Motivation and attitude are two affective factors that can determine the success of students’ learning. The objective of this study is to investigate how attitude and motivation affect students in bilingual teaching programs. This study comprised a total of 159 Spanish students and was conducted in the third and fourth year of primary education in which the level of the L2 corresponds to A2.1 of the CEFR (Common European Framework of Reference). The study involved two schools in the province of Cordoba (Andalusia) in which CLIL (Content and Language Integrated Learning) program is implemented. A quantitative methodology has been used whereby students´ attitude and motivation have been analysed through a questionnaire. The results show that although motivation and attitude are positive in science subjects within the bilingual program, it is necessary to pay greater attention to diversity and to the different pace of learning among students.
How Much Guidance Do Students Need? An Intervention Study on Kindergarten Mathematics with Manipulatives
Authors: Horan Erin Maria , Carr Martha M.
Published: October 2018

Research has shown that the efficacy of learning with manipulatives (e.g., fingers, blocks, or coins) is affected by multiple variables, including the amount of guidance teachers provide during learning. However, there is no consensus on how much guidance is necessary when learning with manipulatives. The goal of this study was to examine the optimal level of guidance during instruction with manipulatives. The focus was on the timing and level of guidance. The researcher taught students a lesson on counting from one to 10 with pennies and nickel strips. Kindergarten students were taught over five consecutive days in one of four conditions: high guidance, low guidance, high guidance that transitioned to low guidance, and low guidance that transitioned to high guidance. Results showed no difference in learning across the conditions. These results provide valuable information to teachers on the areas of mathematics that do not require the effort of high guidance.
Formarse en la Investigación Educativa: una Comunidad de Pensamiento en Torno a la Escritura de la Tesis Doctoral
Authors: Quiles-Fernández Emma , Hizmeri Julio , Hormazábal Fajardo Roxana
Published: October 2018

This article explores educative experiences we had as doctoral students in a community of knowledge inside the University of Barcelona. We deepen understandings around the process we lived for five years, as well as we point out theoretical and methodological aspects that framed the process itself. Embracing narrative inquiry as methodology, we enhance the need of shifting some of the doctoral training practices that traditional academic systems still hold. Through our stories, we show bumps and tensions that might emerge in living and working in a community of knowledge. We also raise challenges that beginning researchers are currently facing in the educational landscape. Those challenges are related to the ways in which we inquire, approach, attend to, and name the research experience in the context of increasingly high academic demands.
Participación de Familias en Educación Física
Authors: Castanedo José Manuel , Capllonch Marta
Published: October 2018

The International Scientific Community identifies the involvement of families in school as a Successful Educational Actions, whose strict implementation leads to the improvement in the academic achievement as well as in the coexistence in the educational context. The aim of this investigation, conducted under the approach of the critical communicative methodology, is to prove how the involvement of the families in education and assessment in the area of Physical Education within the framework of the pedagogical model "Individual Challenges with Shared Responsibility" means an enhancement in all students and their context. The outcomes show an improvement in the academic performance and in the environmental education of students, including those with the greatest barriers. Likewise, this study brings to light the transfer of learning to other contexts and the transformation of the school-family relationship. Besides, it provides evidence on the benefits that it brings to the families that have participated. This study opens up new lines of research into the overcoming of the limitations detected and the improvement of the educational, family and even community contexts.
Indagación Narrativa sobre los Factores que Favorecen el Éxito Escolar en Estudiantes en Situación de Riesgo
Authors: Martín Alonso Diego , Blanco García Nieves
Published: October 2018

Boys and girls at risk or from unfavorable sociocultural backgrounds do not often have a story of school success. However, in spite of the difficulties, there are some who are able to achieve it. The aim of this research is to investigate which pedagogical factors lead male students from an unfavorable background to school success. The focus lies on the experience lived by male students and the meaning they give to their experiences. For these reasons, the paper is outlined from a narrative point of view and it is focused on the experience lived by two male teenagers who are considered to success at school. Data collection has been done through open-ended interviews that lead us to compose students’ narratives of experience. Results –and their analysis- are related to: positive attitude and commitment towards school; construction of a positive self-concept; and the importance of “personalising” the educative relationship.
Mathematics History and Cognitive Values on a Didactic Sequence: Teaching Trigonometry
Authors: Sampaio Figueiredo Helenara Regina , Batista Irinéa De Lourdes
Published: October 2018

This article summarizes the preparation and the results of a study, which aimed to evaluate the effectiveness of historical-philosophical approach in teaching trigonometry in association with the detection of cognitive values, as presented by Lacey. On this association lies the theoretical innovation of the work. To conduct the survey, we organized the activities in sequence as proposed by the Didactic Engineering, based on the history of trigonometry. The study was carried out with high school students of a public school in Londrina and it had a qualitative nature. We have concluded that the approach based on historical perspective with the observation of cognitive values expressed by the mathematics showed being effective for the learning of the Trigonometry and its incorporation into the student's knowledge.
Latinx Bilingual Students' Perseverance on a Mathematical Task: A Rehumanizing Perspective
Authors: Morales Hector , DiNapoli Joseph
Published: October 2018

We draw on a rehumanizing perspective that covets a student-centered viewpoint around the discipline of mathematics. For Latinx bilinguals, we posit that a translanguaging practice is a vital option by which collective perseverance during problem solving can be sustained and leveraged for meaningful learning. This study explores and examines the collaborative efforts of a group of Latinx twelfth-grade students persevering to make meaning of an exponential relationship. We employed a discursive thematic analysis of this groups’ ongoing engagement with a challenging mathematical task, paying specific attention to the ways in which these bilingual students encountered and overcame mathematical obstacles and setbacks. Our findings suggest that Latinx bilingual students can spontaneously and dialogically leverage communicative resources to help persevere with in-the-moment obstacles and build mathematical understandings. We argue for the development of more explicit translanguaging support systems in mathematics classrooms to privilege the viewpoint and experiences of the student, and the ways in which they develop mathematical understandings.
A Sociological Approach to the Rights of Children in Greek Primary Education
Authors: Asimaki Anna , Koustourakis Gerasimos S. , Lagiou Archontoula , Berdeni Nikolitsa
Published: October 2018

The aim of this research paper is the investigation of the rights of children concerning education, as they are set out in the International Convention on the Rights of the Child (1989), and as they are perceived by pupils through the pedagogical practices of their teachers in the primary schools. At the same time the degree of differentiation of the teachers’ pedagogical practices regarding the application of these rights is investigated. In order to carry out this research, in which pupils in year six of Greek primary schools participated, the tool of the semi-structured interview for the collection of research data was used. The main findings of this study revealed that two of the four rights of the children (the right to rest, leisure and play, and the right to freedom of expression and participation) were significantly restricted through the visible pedagogical practices that the teachers applied at the micro-level of the school classroom. In addition, the pedagogical practices applied, concerning the right to primary consideration of the pupils’ best interests and the right to equal treatment, tend towards the rules of an invisible pedagogy, which favours more the common processes of knowledge uptake amongst all the pupils.
Family Engagement with Schools: Strategies for School Social Workers and Educators
Authors: Godoy Julia
Published: October 2018

This article reviews the book '' Family Engagmente with Schools: Strategies for School Social Workers and Educators'' by Nancy Feyl Chavkin
Bullying. Description of the roles of victim, bully, peer group, school, family and society.
Authors: Urra Canales Miguel , Acosta Oidor Catalina , Salazar Baena Verónica , Jaime Ruiz Edwin
Published: October 2018

This research defines, through an extensive literature review, the roles played by the victim, bully, peer group, school, family and society in the dynamics of bullying. Finally, we conclude that the complexity and diversity of the actors should lead us to rethink the traditional definitions of school bullying, to stake out the focus of research projects and to reconstruct prevention and action policies.
Family practices in the construction of creative professionals. A biographical perspective
Authors: Pac David , Serrano Martínez Cecilia
Published: October 2018

The aim of this paper is to analyse the relationships between family configurations and creative occupations. For this purpose, a biographical perspective was taken through the reconstruction of the life histories of sixteen creative professionals in Spain. We have followed two lines of approach, namely Florida’s classification of occupations (2002), which distinguishes between a creative class and a super-creative core, and Lahire’s conception of family configuration (1995). The main results reveal the importance of practices that are carried out on a daily basis by the family network (both internally and externally): reading and writing, cultural consumption (theatre, music, exhibitions, etc.), types of leisure (travelling) and forms of authority that lead the way to self-control and domestic family order. We have shown with this study the importance of the transmission of family culture in the construction of people who have creative occupations and the relationship that exists between the family educational capital and the educational level attained by the offspring.
Construção de conhecimento à distância: a experiência do curso de gestão da inovação em medicamentos da biodiversidade
Authors: Nacif Regina Coeli
Published: October 2018

Este artigo apresenta o Curso de Especialização em Gestão de Inovação em Medicamentos da Biodiversidade, na modalidade Educação a Distância (EAD), uma das realizações do Núcleo de Gestão em Biodiversidade e Saúde - NGBS - no âmbito da Educação, no que se refere à qualificação de gestores da cadeia produtiva de medicamentos da biodiversidade (BRASIL, 2006) com a finalidade de instaurar o trabalho em rede, particularmente, das Redesfito e construir novos pilares para reconstrução das políticas ambientais e da inovação, contribuindo com vários outros setores da sociedade para mudanças de paradigmas de construção de conhecimento. Apresenta-se neste trabalho os fundamentos teórico-conceituais em que a equipe se baseou para a criação do curso, quanto aos processos de formulação e implementação do curso piloto para o Rio de Janeiro, as metodologias aplicadas na estruturação e os resultados obtidos no projeto – piloto, com vistas à adequação do Projeto do curso Nacional, a fim de contribuir para outras iniciativas de igual relevância, atendendo assim, às demandas nacionais no que se refere à qualificação profissional em Gestão da Inovação em Medicamentos.
Biorrefinaria holística de conversão de biomassas por tecnologias sub e supercríticas em produtos para a Nova Bioeconomia Mundial.
Authors: Villela Leonardo Z. , Meirel Maria Angela A. , Mendes Luiz F.
Published: October 2018

A Nova Bioeconomia Mundial, a partir de 2020, visa substituir os produtos petroquímicos pelos derivados das biomassas renováveis, especialmente as que são resíduos da agroindústria (por exemplo, da sucroalcooleira, dos frutos cítricos e da uva). Também está na Agenda da Bioeconomia Mundial, o desenvolvimento e/ou o aprimoramento de tecnologias para aproveitar melhor as biomassas renováveis e, assim, produzir mais produtos aplicando-se industrialmente o conceito de biorrefinarias. Com isso, inevitavelmente, os processos convencionais de extração utilizados para a conversão de matérias-primas renováveis em produtos – que são considerados pouco efetivos (baixa eficiência de extração), geradores de grandes quantidades de rejeitos ao meio ambiente (solventes orgânicos) e outras desvantagens – deverão ser substituídos. Uma tecnologia que se destaca é a de fluidos sub- e supercríticos, por atender aos padrões mais altos de exigências governamentais de sustentabilidade, bem como os aspectos envolvendo a produção de produtos verdes de alta qualidade e seguros às saúdes humana e animal. O desafio de viabilizar economicamente o uso dessa tecnologia tem sido superado à medida que as pesquisas científicas avançam. E é diante deste cenário bioeconômico e dos desafios tecnológicos, que a Bioativos Naturais Ltda. surgiu, tornando economicamente viável a aplicação industrial do conceito de biorrefinaria, com a conversão de biomassas renováveis e resíduos animais em diversos produtos com aplicação nos diferentes segmentos industriais. A Bioativos Naturais Ltda. conta com os apoios investimentos da FAPESP (PIPE), do CNPq e Senai.
O Papel da Revista Fitos na Inovação em Medicamentos da Biodiversidade
Authors: Abreu Rosane De Albuquerque dos S.
Published: October 2018

O objetivo desta comunicação breve é apresentar a construção do papel da Revista Fitos na inovação em medicamentos da biodiversidade. Registra-se, que a principal mudança ocorrida no periódico foi a migração para a modalidade eletrônica, em agosto de 2014, decisão tomada em função do contexto contemporâneo da publicação científica. O interesse pela ciência produzida, não apenas nos bancos acadêmicos, mas também em empresas, organizações sociais, organizações profissionais, entre outros, embasa a divulgação do conhecimento multidisciplinar relacionado à cadeia de desenvolvimento de medicamentos da diversidade vegetal, ressaltando o periódico como instrumento de comunicação científica sobre plantas medicinais. Neste trabalho, apresentam-se os resultados na melhoria da qualidade e na ampliação da visibilidade, essenciais para o periódico assumir seu papel na comunicação científica, apoiando a inovação. Entre 2014 e 2016, mostra-se o crescimento do acesso online e de visualização da página e também foram identificadas as localidades de acesso mundial. A Revista Fitos, depois de eletrônica, foi acessada por diversos países, o que indica alcance internacional do periódico. Com isso, é preciso atuar política e academicamente para que a ciência brasileira possa assumir o papel estratégico do desenvolvimento tecnológico, impulsionando a inovação, especialmente no campo dos medicamentos de origem vegetal.
1º Seminário Internacional da RedesFito: inovação e biodiversidade na perspectiva da sustentabilidade
Authors: Villas Bôas Glauco De Kruse
Published: October 2018

Carta
Cutaneous T-cell lymphomas: modern data of pathogenesis, clinics and therapy
Authors: Demina O. M. , Akilov O. E. , Rumyantsev A. G.
Published: October 2018

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of extranodal non-Hodgkin’s lymphomas that are characterized by skin infiltration with malignant monoclonal T lymphocytes. More common in adults aged 55 to 60 years, the annual incidence is about 0.5 per 100 000 people. Mycosis fungoides, Sézary syndrome and CD30+ lymphoproliferative diseases are the main subtypes of CTCL. To date, CTCL have a complex concept of etiopathogenesis, diagnosis, therapy and prognosis. The article presented summary data on these issues.
Modern concepts of the mycosis fungoides pathogenesis
Authors: Vorontsova A. A. , Karamova A. E. , Znamenskaya L. F.
Published: October 2018

Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted.
Approaches to the prevention and therapy of ibrutinib-associated bleeding in adult patients
Authors: Volchkov E. V. , Zharkov P. A. , Panteleev M. A.
Published: October 2018

Ibrutinib, an irreversible Bruton tyrosine kinase inhibitor (Btk), is a highly effective drug for treatment a number of B-cell lymphoproliferative disorders and, more recently, graft-versus-host disease. However, a number of potentially adverse events are possible in this therapy, partly related to the non-selective mechanism of the drug’s action. Thus, ibrutinib therapy significantly increases the risks of hemorrhagiccomplications compared to standard chemotherapy, especially when combined with a disagregant or anticoagulant therapy, which necessitates the development of clinical recommendations taking into account individual risks for the prevention and treatment of bleeding complications in patients receiving ibrutinib. There is currently an amount of data on the combined use of ibrutinib with disaggregant or anticoagulant therapy is limited, and it is therefore recommended that alternative therapy be considered in patients with a high cardiovascular risk ora reduction in the doses of disaggregante or anticoagulant drugs if abrogation or alternative therapy with ibrutinib is not possible. Also takinginto account the antiplatelet effects of a non-selective Btk inhibitor, a modification of the disaggregant therapy in patients with low cardiovascular risk is possible. This review is summarized available data on mechanisms of bleeding development and proposed strategies for reducingrisks and treating hemorrhagic complications of therapy with ibrutinib.
Infectious complications in patients with acute leukemia according to the duration of neutropenia
Authors: Okhmat V. A. , Klyasova G. A. , Parovichnikova E. N. , Dvirnik V. N. , Troitskaya V. V. , Gribanova E. O. , Savchenko V. G.
Published: October 2018

Introduction. Patients with hematological malignancies undergoing chemotherapy (CT) have high incidence of infections which profile is affected by various factors including neutropenia.

Objective was to evaluate incidence and type of infections in patients with de novo acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) according to neutropenia duration.

Materials and methods. Prospective study (2013–2015) included 110 patients (66 AML, 44 ALL) that received 480 CT cycles throughout 6 month.

Results. Neutropenia with median duration of 15 (2–55) days was in 288 (60 %) of CT cycles. Infections occurred in 242 (50 %) of CT cycles and predominated in neutropenic compared to non-neutropenic patients (80 % vs 6 %, p <0.0001). Infections prevailed in patients with AML compared to ALL patients (93 % vs 18 %, p <0.0001) as in patients with neutropenia (96 % vs 45 %, p <0.0001) and without neutropenia (27 % vs 4 %, p = 0.02). Prolongation of neutropenia from 1–7 days to ≥22 days was associated with increase of infections rate from 52 to 96 % (p <0.0001). Incidence of infections in AML patients was high (92–100 %) regardless of neutropenia duration, whereas in ALL patients it increased from 25–33 to 91 % if neutropenia lengthened from 2 weeks to ≥22 days. During neutropenia the probability of fever of unknown origin was 33.9 %, clinically documented infection – 31.3 %, bacteremia – 17.2 %. They predominated in the first 2 weeks of neutropenia. Probability of invasive aspergillosis (IA) increased after 28 days of neutropenia and reached 66 % on the 55th day. First case of IA in patients with ALL was on 28th day of neutropenia whilst in AML patients – 4 (44 %) of 9 occurred more early (6–16 days of neutropenia). Nine (6 %) of 110 patients died, 4 (4 %) of them due to infection.

Conclusions. Neutropenia was a predictor of infectious complications in patients with AML and ALL. Correlation between duration of neutropenia and incidence of infections was in patients with ALL, whereas in AML patients the rate of infections was high regardless of neutropenia duration. In patients with neutropenia for 2 weeks the most common types of infection were fever of unknown origin, clinically documented infection and bacteremia whilst IA predominated if neutropenia duration was ≥28 days.
Infectious complications in patients with multiple myeloma on first chemotherapy cycle
Authors: Novikova A. A. , Klyasova G. A. , Gribanova E. O. , Okhmat V. A. , Ryzhko V. V. , Savchenko V. G.
Published: October 2018

The aim of the study was to evaluate the profile and risk factors for acquisition of infections in patients with de novo multiple myeloma (MM) on the 1st chemotherapy cycle (CC).

Materials and methods. Study included patients with de novo MM undergoing chemotherapy from January 2013 till November 2017 in National Research Center for Hematology, Russia.

Results. A total of 156 patients with de novo MM (median age 61 years) were included in the study. Follow-up period was 21–82 days (median 26 days), first CC contained bоrtezomib. Infections occurred in 77 (49.4 %) of patients with MM, from them 29 (37.7 %) – on admission, 48 (62.3 %) – throughout treatment. Solitary infections were in 47 (61%) of patients, multiple infections – in 30 (39 %) of patients. The most prevalent type of infection was pneumonia (62.3 %), followed by urinary tract infections (27.3 %) and herpesvirus infections (24.7 %). 30% of patients with infections were afebrile. Significant risk factors associated with infections at admission and during CC were ECOG score 4, anemia, hypercalcemia, humoral immunodeficiency, admission from other hospital, use of antibiotics prior to first CC. Additional risk factors for infections at admission were Durie–Salmon stage III MM, paresis, lower extremity paraplegia and dysfunction of the pelvic organs, whereas during treatment – ISS stage III MM and renal failure. Infections were uncommon in patients with ISS stage I MM (7.8 %). Mortality after 1st CC was 1.9 % caused by pneumonia and acute respiratory failure.

Conclusions. Patients with de novo MM undergoing 1st CC had high incidence of infections with a prevalence of pneumonia. Factors associated with infections were stage III MM, serious illness, admission from other hospital, humoral immunodeficiency, and renal failure.
Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia
Authors: Demina I. A. , Illarionova1 O. I. , Verzhbitskaya T. Yu. , Tsaur G. A. , Rusanova E. B. , Gorchakova M. V. , Zueva E. E. , Belogurova M. B. , Uleiskaya G. I. , Shchekina L. A. , Kazakova A. N. , Zerkalenkova E. A. , Olshanskaya Yu. V. , Abugova Yu. G. , Fechina L. G. , Miakova N. V. , Samochatova E. V. , Maschan A. A. , Popov A. M.
Published: October 2018

Introduction. The main features of bone marrow blasts cells in Burkitt lymphoma/leukemia (BL) are L3 morphology, mature immunophenotype of blasts with surface IgM expression, and presence of typical MYC gene rearrangements.

The aim of the study was to show discrepancy examples in laboratory signs of BL.

Patients and methods. 10 patients (8 boys and 2 girls) aged 1 to 18 years were included in the present study. The inclusion criterion was the identification of discrepancies between flow cytometric, morphological and cytogenetic data.

Results. In 2 cases there were no rearrangements of the MYC gene. In 2 patients, the L2 morphological variant went against the presence of typical MYC gene rearrangements. In one case, undifferentiated blasts cells were described by morphology together with presence of surface IgM, and atypical genetics. In 8 patients, there was no expression of surface IgM. Of these, patients with absence of cytomorphological data cytometric and genetic data were controversial.

Сonclusion. The cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of BL.
Physiological and pathophysiological aspects of blood platelet activation through CLEC-2 receptor
Authors: Martyanov A. A. , Kaneva V. N. , Panteleev M. A. , Sveshnikova A. N.
Published: October 2018

Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic cells in lymph nodes, kidney podocytes and by cells of certain tumors. Association of CLEC-2 with podoplanin is involved in processes of embryonic development (blood-lymph vessel separation and angiogenesis), maintaining of vascular integrity of small vessels during inflammation and prevention of blood-lymphatic mixing in high endothelial venules. However, CLEC-2 and podoplanin are contributing to tumor metastasis progression, Salmonella sepsis and deep-vein thrombosis. This makes CLEC-2 and podoplanin a perspective target for pharmacological treatment. Aspirin and Ibrutinib are considered to be perspective for abrogation of podoplanin-induced platelet activation via CLEC-2. The present review discusses already known pathological and physiological roles of CLEC-2 and possibilities of a targeted therapy for CLEC-2 associated diseases.
Comparative methodological studies of L-asparaginase encapsulation into erythrocytes
Authors: Borsakova D. V. , Plakhotnik M. E. , Koleva L. D. , Bovt E. A. , Alexandrovich Yu. G. , Ataullakhanov F. I. , Sinauridze E. I.
Published: October 2018

Background.L-asparaginase is an enzyme, widely used in the therapy of acute lymphoblastic leukemia in children and adults, but its use is limited due to a wide range of side effects and anaphylactic reactions. L-asparaginase loaded into erythrocytes can solve these problems. This enzyme is protected from the immune system and plasma proteases due to erythrocyte membrane, but continues to work inside the cell because its membrane is permeable to L-asparagine. Thus, the half-life of the drug increases and anaphylactic reactions reduce. The encapsulation of L-asparaginase into erythrocytes can be performed by various osmotic methods. Each of them is characterized by the amount of encapsulated enzyme, the cell yield, as well as by the quality indices of the survived erythrocytes. An important parameter of each method is the possibility to provide sterility of this dosage form for the clinical use.

The aim of the studywas the comparing of three osmotic methods of L-asparaginase encapsulation into erythrocytes (hypo-osmotic lysis, dialysis and flow dialysis) to select the most promising method for clinical use.

Materials and methods.A suspension of erythrocytes of healthy donors (hematocrit 60–70%) was mixed with L-asparaginase from E. сoli. The procedures of hypotonic reversible lysis, dialysis in dialysis bags, or flow dialysis using pediatric dialyzers were performed. The physiological osmolality was restored in suspensions after the procedure by the addition of a hypertonic solution, and they were incubated for 30 min at 37 °C. Then the cells were washed in isotonic phosphate-buffered saline with pH 7.4. Activity of L-asparaginase, volume, hematocrit, hematological indices and osmotic cell fragility of erythrocytes were measured in the suspensions of erythrocytes before and after the enzyme encapsulation procedure.

Results.An optimal osmolality of the hypotonic buffer for each method was selected and was equal to 90–110 mOsm/kg. The yields of encapsulation were 4.2 ± 2.0, 6.0 ± 2.3 and 16.2 ± 2.2 % for hypotonic lysis, dialysis and flow dialysis, respectively. The hematological indices of the obtained erythrocyte-carriers differed from the corresponding parameters of the initial erythrocytes, but did not differ significantly for different methods.

Conclusion.Comparative investigation of mentioned above parameters allowed choosing the method of flow dialysis as the most promising for clinical use.
Falls in the stationary for patients with cardiovascular diseases of the senior age and polypharmacy
Authors: Ilina E. S. , Bogova O. T. , Sinitsina I. I. , Puzin S. N. , Sychev D. A.
Published: October 2018

Background.The fall in the elderly is observed much more often than in younger people, and according to statistics the number of people over 65 years who have suffered a fall during the year reaches 30 %, while the probability of injury. Most of the falls in elderly patients does not lead to injury, but the developing at the same time unfavorable psychological discomfort can sharply limit the usual activity, lead to the formation of dependence on outside help, disadaptation in the home and form a fear of a possible fall. Falls, accompanied by the development of trauma, are observed in 10–15 % of cases.

The objectivewas to study the relationship between polymorbidity, polypragmasia and the development of the fall in elderly patients cardiological profile.

Results.Polymorbidity prevailed in the group of patients who suffered a fall in the hospital (8.9 ± 2.6 vs 7.5 ± 1.5 in men. 8.5 ± 2.2 vs 7.2 ± 1.6 in women). In patients undergoing a decline, it was also noted, and polypharmacy to a greater extent than cohort patients without falling (9.4 ± 1.9 vs 78.4 ± 2.2 in men. and 9.6 ± 2.7 vs 9.1 ± 2.5 for women). In addition, patients who suffered a fall in the hospital by age were older than patients in the comparison group (86 ± 6 vs 85 ± 5 in men, 87 ± 5 vs 84 ± 5 in women). We also revealed the tendency of the predominance of women in the subgroup of patients with the incidence and development of trauma.

Conclusion.Minimizing the amount of drugs received, as the fight against polypragmasy can help reduce the incidence of falls in elderly patients.
Clinical and genetic characteristics of new allele variants of the Mowat–Wilson syndrome caused by ZEB2 gene mutations
Authors: Akimova I. A. , Markova T. V. , Konovalov F. A. , Antonets A. V. , Dadali E. L.
Published: October 2018

To date, a large number of monogenic diseases and syndromes, in the clinical picture of which there are convulsions, a psycho-speech development delay and dysmorphic features have been described. One of the hereditary syndromes with a specific phenotype is the Movat–Wilson syndrome. To diagnose the syndrome, a set of survey methods was used: genealogical analysis, neurological examination, evaluation of intellectual development with the help of psychological tests, and sequencing of the new generation exome. As a result of sequencing exome on the panel of genes responsible for the emergence of hereditary epilepsy, two patients of different sex at the age of 10 and 5 years were identified with previously not described mutations in the ZEB2 gene in the heterozygous state. Clinical manifestations of the disease in these patients were of varying degrees of severity, which can be explained in terms of the functional significance of the changes detected. The variety of clinical manifestations of the same disease leads to considerable difficulties in diagnosing, however, due to the introduction of the nextgeneration sequencing in medical practice, the effectiveness of diagnosing hereditary diseases and syndromes, the verification of which has been difficult for a long time, has increased significantly.
Chronic pain, depression and cognitive impairment: a close relationship
Authors: Latysheva N. V. , Filatova E. G. , Osipova D. V.
Published: October 2018

Over a half of chronic pain (CP) patients present with cognitive complaints, which increase their disability and impact quality of life. The paper reviews objective impairments in memory, attention, processing speed and executive function demonstrated in the CP population. The paper also reviews common pathology underlying cognitive impairment and CP: neuroplasticity in the shared brain areas, neurotransmitter and other molecular mechanisms. Common mechanisms in CP and depression precipitating cognitive impairment are also discussed. The paper also compares the potential of different antidepressants to improve cognitive functions in depression and CP.
Validation of the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS) in Russia
Authors: Yusupova D. G. , Suponeva N. A. , Zimin A. A. , Zaytsev A. B. , Bennett M. , Belova N. V. , Gushcha A. O. , Chechotkin A. O. , Gatina G. A. , Polekhina N. V. , Bundhun Pratish , Ashrafov V. M. , Piradov M. A.
Published: October 2018

Background. Objectivization of the characteristics of neuropathic pain is an important component of differential diagnosis in various diseases. Scales and questionnaires are topical diagnostic tools for assessing subjective symptoms for patients and health professionals.

Objectiveto development and validation of the Russian version of the the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS).

Materials and methods.The study included two stages: linguocultural ratification and assessment of the psychometric properties of the developed Russian version.

Results.The study showed a high level of reliability, validity and sensitivity of the developed Russian-language version of the scale. Conclusion. By the results of the study, the official validated Russian-language version of the scale is presented and recommended for use in work with Russian-speaking patients.
Clinical case study of Kearns–Sayre syndrome: diagnosis, methods of treatment
Authors: Vlasenko S. V. , Ponomarenko E. N. , Kushnir G. M. , Korsunskaya L. L. , Larina N. V. , Shalanin V. V. , Usulceva N. I.
Published: October 2018

The article outlines the current knowledge of the etiology, pathogenesis, clinical features and diagnostic criteria of one of the forms of mitochondrial encephalomyopathy – the Kearns–Sayre syndrome. The observation of a patient with an incomplete case of the Kearns–Sayre syndrome is presented. The complexity of diagnosis and the range of differential diagnostic search as well as approaches to treatment with the use of neurotrophic factors are widely discussed in the research.
Features of high-dose intravenous immunotherapy administration in patients with reduced IgA level in neurological practice: literature review and description of a clinical case
Authors: Rizvanova A. S. , Belova N. V. , Raskurazhev A. A. , Grishina D. A. , Litvinov N. I. , Kutepov D. E. , Ryabinkina Yu. V. , Latysheva T. V. , Suponeva N. A.
Published: October 2018

Intravenous high-dose immunotherapy is one of the highly effective proven treatments for a number of autoimmune diseases of the nervous system. Nowadays there is enough knowledge about the spectrum of side effects and approaches to their prevention and monitoring. Most of them are leveled by improving the technology of the production process, but anaphylactic reactions remain one of the uncontrolled, albeit rare, undesirable reactions. The development of allergic reactions is associated with the presence of antibodies to immunoglobulin class A (IgA) in the patient, which is manifested by a decrease in the level of IgA during routine immunological examination. The article provides a review of the literature on the prevalence of IgA deficiency, its causes. A modern view of the need for routine testing of IgA level before the course of intravenous immunotherapy, approaches to reduce the risk of developing serious adverse reactions in such cases is described. A clinical case of treatment of a patient with chronic inflammatory demyelinating polyneuropathy and a reduced level of IgA is presented.
Response to the article “Bickerstaff brainstem encephalitis, acute transverse myelitis, and acute motor axonal neuropathy: diagnostic and treatment challenges in patients with concomitant syndromes. Clinical observation”
Authors: Suponeva N. A. , Bakulin I. S. , Rizvanova A. S. , Konovalov R. N. , Konovalov Yu. E.
Published: October 2018

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PRIMARY FOUNDATIONS OF THE ARCHITECTURAL FORM
Authors: VALSHIN Rasim M.
Published: October 2018

The article is devoted to the methodology of organization of functional processes of vital activity in architecture in the form of spatial structures. The primary foundations of the generation and emergence of new forms in modern architecture are considered and comprehended. It is shown that the study of a number of modern architecture objects that mark the history of the formation of the modern movement, through analysis, comparison and identifi cation of unique spatial structures, allows us to establish the relationship between the formalism of modern architecture and the new content of the newest architecture. It is noted that modern architecture in its development is able to rely on its own constituent internal forces, transforming primarily the idea of the organization of the functional structure of space. Today the well-known principles of modern architecture used in architecture by the pioneers of the international movement are freely interpreted and developed by many leaders of the newest architecture. The newest architecture demonstrates an intensifi ed search for new methods of spatial thinking solely for the sake of a breakthrough to new principles of shaping in architecture.
Harmonic Analysis of Electrospindle System with Wavelet Packet Transform
Authors: Kıyak İsmail
Published: October 2018

The electrospindle systems have been used in the maritime industry, they
have recently become operative in automation systems. Along with the widespread
use of harmonic generating machines and semi-conductor-based circuits in power
and control systems, known reactive power compensation methods have been
replaced by the use of filter-based compensation systems that consider harmonic
distortion. This study used a voltage signal generated by an electrospindle
generator with high harmonic distortion to obtain the amplitude time variation
of the fundamental component by using Discrete Wavelet Packet Transform (DWPT).
As a result of the analysis, it was observed that this method gives fast and
accurate results that can be also used in real-time applications.
Estimation of Reduced Order Equivalent Circuit Model Parameters of Batteries from Noisy Current and Voltage Measurements
Authors: ALAGÖZ Barış Baykant , ALİSOY Hafiz
Published: October 2018

Identification of reduced order equivalent circuit battery model from current and voltage measurements allows modeling, classification and monitoring of batteries, and these tasks are very essential for battery management systems. This study presents a theoretical study to investigate performance of computer-aided identification of the reduced order equivalent circuit battery model from noisy current and voltage measurement data. The battery model is expressed by fractional order differential equation and time domain solution of this model is numerically calculated according to Grünwald-Letnikov definition of fractional-order derivative. Paper demonstrates an application of this numerical solution in order to fit noisy current and voltage measurement data by using particle swarm optimization (PSO) method. Then, parameters of the equivalent circuit battery model are estimated. Performance of the parameter estimation method is investigated for various noise levels of the synthetically generated current and voltage profiles.
Implementation and Performance Analysis of a Switched Reluctance Motor Fed from Non-Energy Stored PV System
Authors: EFE Serhat Berat , KOCAMAN Behçet , DEMİR AKTAŞ Dilan
Published: October 2018

In this paper, an
actual system that consist of a switched reluctance motor (SRM) and
photovoltaic (PV) generation was analyzed to determine operational behaviors in
terms of both generating and motor units. System was designed without an energy
storage unit. This type of design allows obtaining more convergence and actual
results during operation in different conditions. According to this aim, a
system that includes such structures was constructed physically. System was
operated and observed for different weather and loading conditions. As the
proposed system was aimed to use for agricultural electrical vehicle
applications, results were discussed by using graphs that obtained from various
points, especially in terms of these approaches.
Real-Time Implementation of Continuous Model Based Sliding Mode Control Technique for Trajectory Tracking Control of Mobile Robot
Authors: DUMLU Ahmet , YILDIRIM Mehmet Rasim
Published: October 2018

In this study, real-time trajectory tracking
control of an autonomous mobile robot, actuated by two DC motors, has been
designed, analyzed and studied. Two different control approaches such as model
based sliding mode (SMC) and the classical proportional–integral–derivative
(PID) control are employed to increase the tracking performance of the mobile
robot. A model based SMC technique has been presented in order to consider the
complete dynamic model of the robot and in order to increase trajectory
tracking performance of the system. The experimental outcomes strongly verified
that the proposed controller gives a quite well trajectory tracking response
and smaller magnitude overshot compared with the classical PID controller.
Design and Simulation of Uniform Magnetic Field
Authors: ADİL Mukhamedgali , RAKİSHEVA Zaure
Published: October 2018

This article describes the design,
construction and calculation of the mathematical model of a homogeneous magnetic
field, considering for this Helmholtz coil. Helmholtz coils consist of a pair
of coils along one axis parallel to each other. By varying the distance, size,
winding of these coils, it is enough to simulate a homogeneous magnetic field
that simulates the real Earth's magnetic field in orbit. Circular and square
coils, both with square cross section, are considered. Practical considerations
such as wire selection, wire-wrapping efficiency, wire bending radius, choice
of power supply, and inductance and time response are included. Numerical
calculations of the magnetic flux density, the values of the magnetic field
strength vectors in various directions are presented. The main goal of creating
this simulator is to test the development of algorithms for orientation and
control of the spacecraft, to improve the functioning of the components of the
satellite in the Earth's orbit
Ultra-High Accurate Attitude Determination and Control of Microsatellite Formation Flight
Authors: DOSZHAN Nursultan , GARİP ALİSHER İbrayev Gulama , ROLAND Pilpani
Published: October 2018

Nowadays, technology and space science are
developing rapidly, providing new possibilities for multi-segment missions to
become a frequent practice. This relates to small satellites, which could be
used to organize a formation, in order to solve complex scientific and applied
problems. A formation could serve as distributed instruments for atmospheric
sampling, construct a large distributed antenna platform, or make a large
distributed aperture for imaging and other applications what only a big
satellite can achieve. Small satellite’s formation flying is low cost space
project compared to one big satellite. However, to develop satellite formation
a lot of problems should be solved depending on its mission.

One of the important tasks in small
satellite formation is an accurate determination and control of position and
attitude.  This paper provides a
mathematical modelling of a small satellite’s formation motion, which is
essential to realize a synthetic aperture telescope. Furthermore, the paper
describes the principle of formation configuration and its design.
Application of overfire air technology on an example of a steam boiler PK-39 of the Aksu TPP (Kazakhstan)
Authors: Askarova A. , BOLEGENOVA S.
Published: October 2018

When burning any fossil fuels, one of the
most harmful combustion products are nitrogen oxides NOx, which damage both the
environment and human health in particular. Reduction of NOx emissions from
fuel combustion at TPPs plays an important role in reducing the total level of
nitrogen oxides NOx emitted into the atmosphere. One way to reduce the concentration
of nitrogen oxides NOx is the stepwise combustion of the pulverized coal
mixture, in particular the «Overfire Air» technology. The essence of this
method is that the main volume of air is fed into the pulverized burners, and
the rest of the air is further along the height of the torch through special
nozzles. Structurally, the method of stepwise combustion of fuel can be carried
out in boilers with a two-tier arrangement of burners along the height of the
combustion chamber. In this case, practically no significant reconstruction of
the boiler is required, which is associated with additional costs. In the
present work, computational experiments on the use of modern overfire air
technology (OFA) in the combustion chamber of the PK-39 boiler of the Aksu TPP
were carried out and the fields of the main characteristics of heat and mass
transfer, as well as the influence of the mass flow of the oxidant through the
OFA injectors on the combustion process were obtained.