bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphometric Comparison of Distal Hamate Articular Surface with the Proximal Articular Surface of Middle Phalanges of Index, Middle, Ring and Little Fingers for Hemi-Hamate Arthroplasty
Authors: Kamath B Jagannath , Jain Manesh , N Monish
Published: March 2023

PURPOSE: The study is focused to compare the Distal Hamate articular Surface to the morphology of the base of middle phalanges of Index, Middle, Ring & little fingers. METHODOLOGY: A Observational Paired T study was conducted. Patients with fractures of forearm or hand excluding any fractures in hamate and middle phalanges of Index , Middle, Ring & Little finger of both the upper limbs are subjected to Computed Tomography (CT) of hand and a 3D reconstructed image is obtained. Once the scans are collected, the below parameters will be determined using Radiant software. RESULTS: At the end of this study ,we found that Majority of the patients who underwent CT Scans were noted to be between 31 and 50 years of age. Gender wise, males considered for the study were 24 (52%) and females were 25 (49%). The average hamate axial ridge angle was 69.18 and that of the ring finger middle phalangeal base was 80.23 (P < .05) Out of 50 patients the axial ridge angle of hamate was comparable with ring finger middle phalangeal base. The average distal hamate surface area was 1.04 and that of the middle phalangeal base was 1.00 (P < .05) The distal hamate articular surface area was comparable with the middle finger’s middle phalangeal base. The average sagittal inclination of distal hamate surface was 48.64 and that of the ring finger middle phalangeal base was 49.08 (P < .05) . The sagittal inclination of hamate was comparable with ring finger middle phalangeal base . CONCLUSION: In literature very few radiological studies comparing the hamate and middle phalanx articular surfaces are reported. This study helps us in understanding the digit which is similar to hamate for undergoing Hemi Hamate Arthroplasty and usefulness of pre operative CT scan in further management of chronic proximal interphalangeal joint fracture dislocations. According to the results obtained from our study, we conclude that the Axial ridge angle and sagittal inclination of Middle Phalanx of Ring finger is in close approximation with Hamate . Articular Surface Area of Middle Finger is in close approximation with Hamate distal articular surface area. Keywords: PIPJ- Proximal Interphalangeal Joint, ORIF- Open Reduction, Interal Fixation, CT- Computed Tomography, HHA- Hemi Hamate Arthroplasty
Multi-band chaotic non-orthogonal matrix-based encryption for physical-layer security enhancement in OFDM-PONs
Authors: Song Peiji , Hu Zhouyi , Chan Chun-Kit
Published: March 2023

In this paper, we propose and experimentally demonstrate a novel multi-band chaotic non-orthogonal matrix (CNOM)-based encryption scheme for secure orthogonal frequency division multiplexing (OFDM) passive optical networks. The dimension of non-orthogonality is exploited in the encryption with the CNOM, where both faster-than-Nyquist signaling and redundant precoding were employed to dynamically scramble the original number of subcarriers of each sub-band and fix the overall data rate. Both simulation and experimental results of a 10.6 Gb/s 4-QAM transmission over a 20-km standard single-mode fiber showed that the total key space significantly increases by 1.4×10482 and 1.72×10653 times, as the number of sub-bands increases from 1 to 10 and 15, with a considerable reduction in computational complexity of 90% and 93.33% in complex-valued multiplication, and 90.76% and 94.12% in complex-valued addition, when encrypting one OFDM symbol, respectively. Moreover, the improved resilience to the frequency roll-off has also been verified by using additional permutation matrices in the proposed encryption algorithm.
Measuring spatio-temporal couplings using modal spatio-spectral wavefront retrieval
Authors: Weisse N. , Esslinger J. , Howard S. , Foerster F. M. , Haberstroh F. , Doyle L. , Norreys P. , Schreiber J. , Karsch S. , Döpp A.
Published: March 2023

Knowledge of spatio-temporal couplings such as pulse-front tilt or curvature is important to determine the focused intensity of high-power lasers. Common techniques to diagnose these couplings are either qualitative or require hundreds of measurements. Here we present both a new algorithm for retrieving spatio-temporal couplings, as well as novel experimental implementations. Our method is based on the expression of the spatio-spectral phase in terms of a Zernike-Taylor basis, allowing us to directly quantify the coefficients for common spatio-temporal couplings. We take advantage of this method to perform quantitative measurements using a simple experimental setup, consisting of different bandpass filters in front of a Shack-Hartmann wavefront sensor. This fast acquisition of laser couplings using narrowband filters, abbreviated FALCON, is easy and cheap to implement in existing facilities. To this end, we present a measurement of spatio-temporal couplings at the ATLAS-3000 petawatt laser using our technique.
Variation in the tonoplast cadmium transporter heavy metal ATPase 3 (HMA3) homolog gene in Aegilops tauschii
Authors: Li Shengke , Li Xiao , Li Shijie , Liu Yu’e , Zang Tianqing , Hao Ming , Zhang Lianquan , Huang Lin , Jiang Bo , Yuan Zhongwei , Chen Xuejiao , Chen Xue , Liu Dengcai , Ning Shunzong
Published: March 2023

The functionality of HMA3 is a key determinant controlling Cd accumulation in the shoots and grains of plants. Wild relatives of modern crop plants can serve as sources of valuable genetic variation for various traits. Here, resequencing of HMA3 homoeologous genes from Aegilops tauschii (the donor of the wheat D genome) was carried out to identify natural variation at both the nucleotide and polypeptide levels. HMA3 homoeologs are highly conserved, and 10 haplotypes were revealed based on 19 single nucleotide polymorphisms (eight induced single amino acid residue substitutions, including 2 altered amino acids in transmembrane domains) in 80 widely distributed Ae. tauschii accessions. The results provide genetic resources for low/no Cd concentration wheat improvement.
Conditions for cooperative forest management on Capercaillie (Tetrao urogallus L.) lekking sites in Finland
Authors:   University of Eastern Finland, Faculty of Science, Forestry and Technology, School of Forest Sciences, Ikonen Piia
Published: March 2023

In Finland, private forest owners own nearly 60% of forest land. The average size of a private forest property is around 30 hectares. Many owners identify as multi-objective owners with varying management goals related to recreation, biodiversity, and scenery, in addition to timber production. The aim of this research was to assess how a cooperative approach to game-oriented forest management could be perceived by forest owners and also to evaluate the type of mechanisms that influence how cooperative management principles could be put into practice. Game-oriented forest management refers to forestry practices that aim to maintain the habitats of grouse species, such as the highly-valued game species capercaillie (Tetrao urogallus L.). The lekking sites of capercaillie are extensive (up to 20 hectares) and can be located on several private properties. Game-oriented management applied in lekking sites could improve the quality of the sites but would require a cooperative management approach across property boundaries. However, the openness of forest owners to game-oriented or cooperative forestry practices has been unknown. This research consisted of two double-sampling survey studies that included three surveys (two for forest owners, one for forest professionals) and one qualitative interview study with forest owners, which together explain the use of game-oriented and cooperative forest management methods, the type of beliefs that forest owners associate with cooperative management of lekking sites, and how willing and ready they are to participate in cooperative forest management practices. The results indicated that game-oriented forest management methods are increasingly approved by forest owners, and that the forest owners are intrigued by cooperation. However, currently independent forest management, norms, restricted services and communication between forest owners may hinder their interest in participating in cross-boundary forest management. The findings also emphasise the importance of forest owners’ decision-making power in cooperative forest management. Cooperative schemes promoted through cooperation between forest owners with similar goals could yield optimal management solutions across wide habitats of capercaillie.
Estudo da viabilidade econômica do reaproveitamento do óleo de víscera para produção de biodiesel em uma empresa de processamento de carne de frango em Minas Geraisc
Authors: Souza Marcella Ramos de , Abreu Sanderson Rocha de
Published: March 2023

A produção de carne de frango no Brasil aumentou expressivamente nos últimos anos, contribuindo com o crescimento econômico do país, haja vista a destacada participação do agronegócio no PIB nacional. Contudo, esta atividade gera uma quantidade significativa de resíduos sólidos provenientes do processamento das aves como penas, sangue e vísceras, com potenciais impactos ao meio ambiente. No Brasil, o adequado gerenciamento dos resíduos industriais é de responsabilidade dos respectivos geradores, podendo representar riscos ao empreendimento, quer seja na forma de despesas com seu tratamento e/ou sua disposição final, ou ainda sob a forma de passivos ambientais. Neste contexto, o objetivo deste trabalho foi avaliar a viabilidade econômica do reaproveitamento do óleo de vísceras gerado no abate de frangos para a produção de biodiesel por meio de uma usina de processamento, proposta apoiada nas diretrizes do modelo de Economia Circular. Para isso, foi realizado um diagnóstico da geração de resíduos em uma empresa de processamento de carne de frango no Estado de Minas Gerais, Brasil. A metodologia aplicada fez uso dos indicadores de viabilidade econômica. Os valores encontrados a partir dos cálculos dos indicadores, basearam-se em uma taxa pré-determinada de conversão do óleo de vísceras em biodiesel. Os indicadores mostraram que o empreendimento é viável, obtendo um resultado satisfatório como por exemplo o payback de 1,2 anos. Assim foi possível fazer a análise do cenário atual e futuro, mostrando que o cenário proposto por este trabalho pode trazer ganhos para a empresa objeto de estudo.
Análise de práticas de gestão adotadas por empresas de benefício
Authors: Abreu Caio Francisco Ternus de , Abreu Bernardo Ternus de , Borchardt Miriam
Published: March 2023

As empresas de benefício (benefit corporations, ou empresas B) são organizações que estão voltadas a gerarem impactos socioambientais positivos para a comunidade local em concomitância com a produção de lucro para os seus proprietários e/ou acionistas. Nos últimos anos, essas empresas B têm recebido uma atenção maior por parte de pesquisadores acadêmicos, porém ainda são escassos os trabalhos que se debruçaram realizando uma revisão de literatura (RL) em conjunto com estudo de casos para encontrar as práticas exemplares (estado de arte) em gestão para esse tipo de empresa. Através de uma RL e de estudo exploratório (questionários e entrevistas), este trabalho almeja apontar as melhores práticas para as empresas B da área de serviços, considerando que os eixos encontrados na avaliação de impacto de negócio (BIA) são: governança, trabalhadores, meio-ambiente, comunidade e consumidores. As empresas escolhidas para o estudo obtiveram pontuação ótima na avaliação BIA mais recente. Esse trabalho propõe sugestões e diretrizes para organizações definirem suas estratégias para o futuro. Ao final, este trabalho indicou as práticas efetuadas pelas empresas estudas e como estas contribuem positivamente com os objetivos de desenvolvimento sustentável (ODSs). Tal resultado poderá servir de base para outras organizações que desejem ampliar seus impactos positivos na sociedade por meio de suas atividades produtivas e comerciais.
Priorização de ordens de serviço aplicando métodos de tomada de decisão
Authors: Alves Luis Gabriel de Alencar , Tavares Frederico Romel Maia , Mendonça Francisca Jeanne Sidrim de Figueiredo , Duarte Ana Karine Gomes
Published: March 2023

O presente estudo de caso apresenta o desenvolvimento e a aplicação de um sistema de gerenciamento de ordens de serviço em uma empresa provedora de internet, além da integração de recursos para priorização dessas ordens a partir da utilização de métodos de tomada de decisão multicritério. Dentre os métodos estudados, foram selecionados o método AHP e o método PROMETHEE. O método AHP é utilizado para os cálculos dos pesos dos critérios e o método PROMETHEE é aplicado em seguida para realizar os procedimentos de priorização das ordens de serviços utilizando os pesos obtidos anteriormente. O sistema foi desenvolvido e integrado a um algoritmo contendo os métodos de decisão para que as priorizações das OS tornem-se automáticas e sejam recalculadas a partir da criação de uma nova ordem de serviço. Os resultados da implementação do sistema foram obtidos por meio da análise das alterações e de entrevistas estruturadas realizadas com os principais funcionários sobre o impacto que o uso do software causou no seu cotidiano. Foi possível apontar melhorias, como aumento na organização empresarial e maior eficiência no atendimento dos clientes.
Inovação de processos
Authors: Santos Carlos César Ribeiro , Carvalho Leonardo Sanches de , Russel Ricardo de Oliveira Monteiro , Donato Vitório , Santos Jonata Souza dos
Published: March 2023

Embora o potencial da inovação aberta para desenvolver melhorias relacionadas ao produto por meio do uso de fontes externas de conhecimento seja inegável, nossa compreensão de como as empresas se tornam inovadoras de processo permanece limitada. É importante distinguir entre inovação de produto e de processo, pois os insights obtidos na investigação da inovação de produto podem não estar diretamente relacionados ao estudo da inovação de processo. O objetivo deste artigo foi descrever cases práticos desta inovação e o seu potencial para garantir processos produtivos mais sustentáveis no setor industrial. Além disso, propomos uma matriz de analise que acompanha como a inovação de processos pode permitir à transição de empresas para a à indústria 4.0. Os resultados apresentados pelos cases descritos nesta pesquisa, apontam uma relação direta entre a inovação de processos e o aumento da produtividade e inovação nas organizações estudadas.
Uso de ferramentas para análise da confiabilidade da logística inbound internacional de uma empresa do Polo Industrial de duas rodas em Manaus
Authors: Nery Cibelle Lima Pereira , Freires Vitória de Melo , Oliveira Marcelo Albuquerque de
Published: March 2023

O artigo pretende abordar o desenvolvimento dos impactos instaurados pelo contexto pandêmico, onde os fabricantes do mundo todo presenciaram grande escassez de recursos e matérias primas para seus respectivos processos produtivos, além de impactar no tempo de atraso para chegada de material. O artigo objetiva analisar os pedidos e entregas de fornecedores internacionais de uma empresa do Polo Industrial de Manaus (PIM) para um intervalo de tempo entre os anos de 2019 a 2021. Para dar apoio a metodologia escolhida foi utilizado, principalmente, as ferramentas de análise de controle de ordens, como os diagramas Throughput Diagram (TD) e Order Progress Diagram (OPD). O presente artigo se trata de um estudo de caso, e refere-se a uma abordagem mista, quantitativa e qualitativa, pois busca analisar os cenários baseados nos valores numéricos e conceitos. O estudo se mostrou satisfatório uma vez que foram alcançados os objetivos propostos e através do estudo foi possível ser feito uma análise das causas raízes dos atrasos de pedidos, através do Ishikawa, e por fim traçado um plano de ação para a problemática em questão.
Evaluation of Tru-Cut biopsy in differential diagnosis and challenges in breast adenoid cystic carcinoma on a case basis
Authors: Sayar İlyas , Memiş Ufuk , Bilici Sami , Arslan Isik Nurten
Published: March 2023

Adenoid cystic carcinoma (AdCC) is a very rare low-grade invasive carcinoma primarily in the breast. The fact that similar patterns can be observed in invasive breast carcinomas (IВC) such as AdCC and breast ductal carcinoma in situ (DCIS) in Tru-Cut biopsies creates difficulties in the differential diagnosis.
Case presentation. A 70-year-old female patient was admitted to our outpatient clinic with the complaint of a palpable mass in the left breast subareolar region. In the light microscopy examination of 3 tissue samples with a size of 3 measurements, IBC-like tubular structures, some of which were formed by tiny uniform cells with narrow cytoplasm, and some with eosinophilic material, and solid nest structures suggesting DCIS in focal areas were observed.
Immunohistochemical examination showed continuity of myoepithelial cells with p63 and calponin, and epithelial cells, staining with Cd117 and CK7. No staining was observed with progesterone, estrogen, and Cerbb2. The staining rate of Ki-67 was determined as 2 percent. A diagnosis of AdCC was made with these findings.
Conclusions. It is important to search for different patterns in addition to double cell population and pay attention to the material in the lumens in breast Tru-Cut biopsies that contain AdCC patterns that may cause the diagnosis of IBC and DCIS in error.
Matrix metallopeptidase 9 and outcome prediction in patients with acute coronary syndrome
Authors: Bilchenko A. O. , Vyshnevska I. R. , Hilova Ya. V. , Kopytsia M. P.
Published: March 2023

The aim of this review was to analyse the scientific literature data on matrix metallopeptidase 9 and to analyse the available information on its prognostic value as a marker of negative outcome in the short- and long-term prognosis in patients with acute coronary syndrome.
Materials and methods. In our study was used a recursive literature search strategy at PubMed. The following criteria for inclusion in the analysis were defined – a prospective study in patients with acute coronary syndrome that had data on the effect of MMP-9 levels on short-term and/or long-term outcomes, including mortality and major adverse сardiovascular events. Review articles, clinical cases, animal studies, and studies with insignificant statistical data were not included in the analysis. The depth of the initial search was set at 15 years with a search for similar articles in citations. We selected 5 studies for meta-analysis. Meta-Essentials 1.5 was used for the analysis. Odds ratio and 95 % confidence interval were calculated using the Haenszel method. The association between MMP-9 levels and short-term and long-term outcomes (mortality and major adverse CV events) was determined. The statistically significant level was defined as P < 0.05.
Results. The analysis showed no significant association between the level of MMP-9 and the outcome (OR = 1.39; 95 % CI = 0.25–7.79; P = 0.595; I2 = 78 %).
Conclusions. Matrix metallopeptidase 9 is a promising marker for further investigation of its predictive strength of outcome. Despite the opposite results of single studies and no significant association of MMP-9 with outcome further research on this issue is a promising direction.
Vegetative and electrical disorders in women with chronic coronary syndrome depending on the state of bone mineral density
Authors: Mykhailovska N. S. , Stetsiuk I. O.
Published: March 2023

Aim: to determine the features of heart rate variability and electrical changes in the myocardium in women with chronic coronary syndrome, depending on the state of the bone mineral density (BMD).
Materials and methods. 121 women with chronic coronary syndrome (CCS): stable exertional angina of II–III functional class (FC) (mean age 68.0 (60.0; 75.0) years) were examined and divided into 3 groups: group 1 − 30 women with ССS and normal BMD; group 2 – 33 women with CCS and osteopenia (OPе); group 3 – 58 women with CCS and osteoporosis (OP). All patients underwent daily ECG monitoring and ultrasound osteodensitometry.
Results. In women with CCS and OP, increase in the frequency (by 2.9 times; P < 0.05) and duration (by 2.3 times; P < 0.05) of tachycardia episodes, the frequency of registration of ventricular and supraventricular extrasystole episodes (by 8.1 time and 1.2 times, respectively; P < 0.05) if compared to patients without BMD disorders was found. In women with СCS and OPе there was a tendency to increase in these indicators, which did not reach the level of statistical significance. The presence of BMD disorders in patients with CCS was accompanied with decrease in total HRV activity (RMSSD and HRVT), the development of the predominance of ANS sympathetic domain activity, as evidenced by an increase in LF by 44.3 % at the daytime and 44.0 % at night, decrease in HF 2.3 times during the day and 2.1 times at night in patients with OPe and OP, respectively. According to the correlation analysis data, the presence of correlations between the state of BMD and indicators of electrical and autonomic activity of the myocardium was established.
Conclusions. In postmenopausal women with CCS, the severity of autonomic and electrical disorders is associated with the degree of bone disorders and is maximal in osteoporosis.
The level of antimicrobial peptides in different clinical forms of urinary tract infections in children
Authors: Lezhenko H. O. , Zakharchenko N. A.
Published: March 2023

The aim. To study the content of antimicrobial peptides in the serum of children with urinary tract infections depending on the clinical form of the disease and to establish their pathogenetic role in the development of various clinical forms of pathology.
Materials and methods. The study groups consisted of 84 children (mean age – 10.0 ± 1.3 years). The main group was divided into subgroups: the first subgroup – 17 children with acute pyelonephritis, the second subgroup – 21 patients with chronic pyelonephritis, the third subgroup – 16 patients with acute cystitis, the fourth subgroup – 10 patients with unspecified urinary tract infections. The control group consisted of 20 relatively healthy children. The study of the content of cathelicidin, hepcidin and lactoferrin was performed by enzyme-linked immunosorbent assay.
Results. The development of urinary tract infection was accompanied by a statistically significant increase in the content of cathelicidin (P < 0.05). The highest level of serum cathelicidin was registered in children of the first (P <0.05) and third subgroups (P < 0.05). In the other two subgroups, the level of LL-37 had only a trend towards increasing (P > 0.05). The level of hepcidin in the main study group was statistically lower than in the control group (P < 0.05).
The development of chronic pyelonephritis and acute cystitis occurred amid a statistically significant decrease in hepcidin levels by 2.5 and 1.7 times (P < 0.01 and P < 0.05, respectively). The level of lactoferrin in the general group was within the control group figures (P > 0.05), however, there was a statistically significant decrease in serum lactoferrin in a subgroup of children with unspecified urinary tract infections (P < 0.05).
We determined a relationship between hepcidin and lactoferrin levels in the investigated groups and found a clear direct relationship in a subgroup of children diagnosed with chronic pyelonephritis (r = 0.58, P < 0.01).
Conclusions. Each nosological form of urinary tract infection has its own configuration of antimicrobial peptides. The analysis of the relationship between hepcidin and lactoferrin, the antimicrobial peptides that limit the access of the pathogens to serum iron, indicates the synchronization of the body’s defense mechanisms aimed at eliminating the pathogen.
Evaluation of antireflux surgery effectiveness in patients with hiatal hernia
Authors: Klymenko A. V. , Kravchenko B. S. , Klymenko V. M. , Serhieieva L. N. , Kravchenko S. M. , Tkachov V. S.
Published: March 2023

The generally accepted gold standard in the surgical treatment of hiatal hernias is laparoscopic fundoplication with cruroplasty. At the same time, the problem of choosing the best method of fundoplication to improve the results of surgical intervention remains disputable.
Aim. Determination of the effectiveness of antireflux interventions and the frequency of postoperative dysphagia in patients with esophageal hernia.
Materials and methods. The results of 38 patients in the early and late postoperative period, operated with the use of Nissen and Toupet fundoplication, with an integrated exhaustive examination of the manifestations of dysphagia syndrome were analyzed. 17 (44.7 %) patients (first group) underwent laparoscopic posterior crurorraphy with Nissen fundoplication in the Short-Floppy-Nissen modification, and 21 (55.3 %) patients (second group) underwent posterior crurorraphy with Toupet fundoplication.
Results. In the postoperative period, the intensity of pain on the rating scale was minimal in 70.6 % and 71.4 %; moderate in 23.5 % and 14.3 %; strong in 5.9 % and 14.3 % of the patients in the first and second groups, respectively. The first degree of dysphagia (the ability to ingest liquid food and fluids) was observed in 5 of 17 (29.4%) patients of the first group, with subsequent regression in 4 of 5 patients within 5 days; in the second group there was no dysphagia. When comparing the results of all scales of integrated analysis of the quality of life of the patients of both groups, no significant difference was found between them.
Conclusions. The obtained data demonstrate the compatibility of both methods, in the absence of differences in quality of life and patient’s satisfaction in the late postoperative period. Differences in the frequency of dysphagia syndrome after surgery indicate the need for a more differentiated approach to the choice of fundoplication technique.
Comparative characteristics of the regeneration of the femur bone of rats at intramedullary osteosynthesis using medical steel and carbon-carbon composite material
Authors: Chornyi V. V. , Bohdanov P. V.
Published: March 2023

The aim of this study was to compare the morphological features of rat femoral bone regeneration during intramedullary osteosynthesis using medical steel and carbon-carbon composite material.
Materials and methods. All animals were divided into two groups. A fracture of the thighbone was simulated by surgical intervention. In the first group, medical steel was used for intramedullary fixation of fragments; in the second group, fragments were fixed using a carbon-carbon composite material. The morphological, morphometric, histological, histochemical, immunohistochemical and X-ray methods was used, the bone regenerate was studied on the 30th day, 6 and 12 months after the surgical intervention. There were established expression of immunohistochemical markers CD-34 and Ki-67 using the ImageJ program. The statistical analysis of the obtained results was performed by the methods of variational statistics using the program Statistica 13.0.
Results. In the group of animals where composite material was used, on the 30th day after surgery, a statistically significant increase in the expression of the relative area occupied by CD-34+ structures compared to the second group of animals was established (4.80 ± 0.40 in the group in which the composite material was used and 2.80 ± 0.30 in group in which the medical steel was used). Also a statistically significant increase in the expression of the Ki-67+ marker was established (5.20 ± 0.36 in the group in which the composite material was used and 2.48 ± 0.32 in group in which the medical steel was used). With inspection microscopy, faster rates of osseointegration and regeneration of the fracture site were observed in the group of animals in which the composite material had been used compared to the other group of animals due to the stimulation of vascular endothelium growth. The data of the histological examination coincide with the data of the X-ray examination at all the periods of observation.
Conclusions. The use of carbon-carbon composite material during intramedullary osteosynthesis accelerates bone regeneration pace due to the angiogenic effect, which is confirmed by increase in the expression of markers of proliferative activity Ki-67+ and the marker of vascular endothelium CD-34+ in the group of experimental animals in 30 days.
Prognostic role of demographic indicators and Charlson comorbidity index in oxygen-dependent patients with coronavirus disease (COVID-19)
Authors: Cherkaskyi V. V. , Riabokon O. V. , Riabokon Yu. Yu.
Published: March 2023

Aim. The aim of our work is to establish the prognostic significance of demographic indicators and the Charlson comorbidity index (CCI) in oxygen-dependent patients with coronavirus disease (COVID-19).
Material and methods. The research included 211 oxygen-dependent patients with COVID-19: I group – 94 patients who recovered; II group – 117 patients, the disease ended fatally. We used the WHO age classification when analyzing the age structure of patients. The Charlson comorbidity index was calculated for each patient. The patients were divided into groups Statistical data processing was carried out in the program Statistica for Windows 13 (StatSoft Inc., No. JPZ804I382130ARCN10-J).
Results. It was established that the median age of the ІІ group patients was higher (P < 0.001) than patients the I in group. Elderly patients were more often registered in the ІІ group than among patients in group I (25.6 % vs. 8.5 %, P = 0.001). Middle-aged patients were more often registered in the І group than among patients in the II group (34.0 % vs. 19.4 %, P = 0.02). According to the result of the ROC analysis, the prognostic value of the age of the patients was established, namely, under conditions of age >66 years (AUC = 0.636, Р = 0.002), the probability of a fatal outcome of COVID-19 was significant.
Analysis of the influence of comorbid conditions on the risk of COVID-19 fatal outcome in oxygen-dependent patients according to the CCI showed that the absence of comorbid pathology was more common among patients of group I than among patients of group II (12.8 % vs. 2.6 %, P = 0.004). The level of CCI in patients of the II group significantly exceeded the corresponding indicator of the patients of the I group (P < 0.01), who recovered. According to the obtained result of the ROC analysis, the prognostic value of this indicator was established, namely under the conditions of the CCI index >5 in oxygen-dependent patients with COVID-19 (AUC = 0.652, P < 0.001) the probability of fatal outcome of the disease was significant.
Conclusions. In oxygen-dependent patients with COVID-19, patient age and comorbidity are associated with disease outcome. Under conditions of age >66 years (AUC = 0.636, P = 0.002) and the Charlson comorbidity index >5, the probability of a fatal outcome of the disease is significant (AUC = 0.652, P < 0.001).
Chronic atrophic gastritis as a precancer: the evolution of ideas from the Sydney consensus to Maastricht VI
Authors: Stepanov Yu. M. , Haidar Yu. A. , Maltseva O. A.
Published: March 2023

Aim. The purpose of the work is the evolution of systems and classifications of gastritis: Sydney Consensus (1990), Houston Modification (1994), OLGA/OLGIM (2008), Kyoto (2014), MAPS II (2019), Maastricht IV (2022).
Materials and methods. During the work, 25 sources of information were used.
Results. Chronic atrophic gastritis (ChAG) is a clinical and morphological diagnosis, and the presented clinical forms (types) of gastritis have characteristic morphological criteria. According to the Sydney system, changes in the antrum and body of the stomach are described separately. This has led to a lack of clear risk stratification criteria for CG and also complicates the objective analysis of regression of inflammation and atrophy. OLGA/OLGIM systems were proposed to determine the stage of atrophy and IM. The authors of the Kyoto consensus add and clarify the etiological section of ChAG. In MAPS II, ChAG and IM are considered precancerous conditions, as they increase the risk of developing gastric cancer and are the background for the occurrence of dysplasia and adenocarcinoma. For patients with dysplasia and the absence of visible changes in the mucous membrane, high-resolution endoscopy with staining is recommended. They should be examined after 6 months for a high degree of dysplasia and after 12 months for a low degree of dysplasia. Patients with IM and one localization have a high risk of developing gastric cancer. However, the high risk does not give the right to follow up in the majority of cases when high-quality endoscopy with biopsy does not show severe atrophy. Patients with IM of one location, with a family history of cancer, or with incomplete IM and persistence of H. pylori chromo endoscopy with biopsy must be done once every 3 years. Patients with extended fields of atrophic aggression (pronounced atrophic changes) or IM in the antrum and body, OLGA/OLGIM III/IV should be screened with chromoendoscopy with biopsy every 3 years. Patients with significant atrophy and familial cancer benefit from chromoendoscopy and biopsy every 1–2 years after initial diagnosis. Patients with autoimmune gastritis are recommended to be screened every 3–5 years. According to Maastricht VI, H. pylori is the main etiological factor of gastric adenocarcinoma, including proximal gastric cancer.
Conclusions. After careful study and analysis, we came to the conclusion about the gradual development of the principles of evidence-based medicine in the issue of improving the clinical and morphological diagnosis of chronic atrophic gastritis as a precancerous of the stomach.
Pharmacognostic studies of Trifolium fragiferum L. flora of Southern Ukraine
Authors: Grechana O. V. , Serbin A. H. , Salii O. O. , Rudnyk A. M. , Shevchenko I. M. , Fukleva L. A.
Published: March 2023

The work is devoted to the study of herbs of the representative genus Clover Trifolium fragiferum L. from the south Ukrainian flora.
The aim of this research is to investigate the representative of Southern Ukraine flora Trifolium fragiferum L. which has a sufficient raw material base and use in folk medicine.
Materials and methods. Samples were grown in the suburbs of Zaporizhzhia and harvested during full flowering (May – June). Microscopic analysis was performed with temporary preparations of leaves and stems. Plant extracts were analyzed chromatographically using an Agilent Technologies 6890 gas chromatograph with mass spectrometric detection.
Results. The leaf is covered with parenchymal cells with slightly thickened membranes with anocytic stomata. The main parenchyma is composed of rounded toxoid cells. Stem rounded, covered with elongated parenchymal cells with thin membranes with almost no stomata and pubescence. Central axial cylinder is of beam type. Beams are open collateral, large. Above the phloem of the bundles is a multilayered sclerenchyma. The core is partially filled, hollow in the center. 63 compounds were found in the native extract, of which 37 were identified: coumarins, fatty acids, diterpene alcohols, oxygenated hydrocarbons of terpenoid nature, higher hydrocarbons, representatives of phytosterols, and phytosterols. After acid hydrolysis with sulfuric acid, 58 compounds were found, of which 49 were identified: coumarins, alcohols and phenols, aldehydes and ketones, compounds of diterpene nature.
Conclusions. Pharmacognostic analysis of the genus Clover Trifolium fragiferum L. revealed diagnostic microscopic signs of leaves and stems. The components of the native extract are compared, and after its acid hydrolysis. Certain regularities in the distribution of classes of substances that characterized certain types of extracts were revealed: monoterpenoids, aromatic, heterocyclic compounds characterized the hydrolyzed product. Sesquiterpenes and steroid compounds are found only in the native extract of strawberry clover herb. Alcohols, aldehydes, and ketones were the majority in the hydrolyzed extract, and hydrocarbons were observed more in the native. Only 5 components were identified in both extracts: nonacosan, 2-phenoxyethanol, loliolide, dihydroactinidiolide and coumarin with significant differences in amounts.
Chromato-mass spectroscopy of tinctures from the underground part of Valerian plants growing in Zaporizhzhia region
Authors: Odyntsova V. M. , Korniievskyi Yu. I. , Skoryna D. Yu. , Korniievska V. Н.
Published: March 2023

Modern sedatives used in medical practice can be of both synthetic and natural origin. It is known that the best phytosedative is valerian. In the 18th century, valerian was included in all European pharmacopeias. High efficiency, good tolerability, and virtually no side effects ensure the widespread use of valerian and its phytopreparations in medical practice, especially for the treatment of geriatric patients. Despite this, valerian remains understudied due to its extreme polymorphism.
The aim of the work is to determine the component composition of valerian tinctures made from rhizomes with valerian roots of different species growing in the Zaporizhzhia region by gas chromatography and to carry out their comparative analysis.
Materials and methods. Samples of rhizomes with valerian roots made from medicinal plant raw materials of valerian according to the traditional production recipe (Tinctura Rhizomata cum radicibus Valerianae (1:5)) from different species of valerian growing in the Zaporizhzhia region were selected for experimental studies: Valerian stolonifera Czern. – Kantserivska Balka, Zaporizhzhia district, Zaporizhzhia region; V. exaltata Mikan. – Shyroke village, Vasylivskyi district, Zaporizhzhia region; V. tuberosa L. – Khortytsia Island, Zaporizhzhia; V. collina Wallr. – right bank of the Dnieper River, Zaporizhzhia. The component composition of valerian tinctures was studied using an Agilent 7890B gas chromatograph with a mass spectrometric detector 5977B.
Results. The component composition of tinctures from the underground part of valerian plants growing in the Zaporizhzhia region was identified and analyzed with chromato-mass spectrometry.
Conclusions. 55 components in valerian tincture from underground raw materials of Valeriana stolonifera Czern. were identified with gas chromatography: V. exaltata Mikan. – 48, V. tuberosa L. – 54, V. collina Wallr. – 51. Analyzing the obtained data, we can conclude that valerian tinctures differ in both quantitative and qualitative composition. Only compounds 7 and 9 coincide in tinctures from underground parts of all four types of valerian. Since the tinctures were made following the standard technology, the content of components in medicinal plant raw materials depends on the type, place of growth, environmental conditions, time of collection, drying of raw materials. The results of the study confirm the prospects of using the underground part of the studied plants of the genus Valerian to create new drugs and phytopreparations on their basis. However, given the extreme polymorphism of valerian for the introduction into the culture of promising species that grow in Ukraine, it is necessary to conduct more in-depth pharmacognostic and pharmacological studies of plants of this genus.
Prognostic value of P-selectin and sST2 in patients with multiple myeloma
Authors: Panasenko M. O. , Samura B. B. , Dotsenko S. Ya.
Published: March 2023

Cardiac involvement is one of the most important prognostic markers in multiple myeloma. However, prognostic value of novel biomarkers, such as soluble suppression of tumorigenicity 2 (sST2), P-selectin is unknown in multiple myeloma.
The aim of the work was to investigate the additive predictive effects of novel biomarkers P-selectin and sST2 for cardiovascular events of multiple myeloma patients.
Materials and methods. Levels of P-selectin and sST2 were after anticancer treatment in a total of 67 multiple myeloma patients. The median follow-up duration of the censored cases was 14.0 (11.4–19.1) months. A total of 4 deaths occurred during the follow-up period. ELISA method for measurements of circulating level of P-selectin and sST2 was used.
Results. During follow-up, 36 cardiovascular events and 2 deaths unrelated to cardiovascular events were recorded in 18 (26.9 %) patients. During the study, patients were hospitalized 10 times due to cardiovascular disease. At baseline patients with MM and cardiovascular events which appeared during the observation period had higher levels of P-selectin (P < 0.01), sST2 (P = 0,018), compared to patients without cardiovascular events.
Two novel biomarkers, P-selectin and sST2 showed satisfactory predictive performances for one-year cardiovascular events from ROC analysis. Best cut-off values for predicting one-year cardiovascular events were selected (for sST2 – 31.05 ng/ml, with a sensitivity of 71.5 % and a specificity of 89.8 %; for P-selectin – 54.21 ng/ml, with a sensitivity of 69.6 % and a specificity of 86.2 %). The combination of biomarkers had better prognostic properties compared to P-selectin.
Conclusions. In patients with confirmed multiple myeloma, the biomarkers P-selectin and sST2 showed significant prognostic properties in the occurrence of cardiovascular events during 1 year of follow-up.
The renal function in men with hypertension in conditions of purine and carbohydrate metabolism disorders
Authors: Dudko O. V. , Kolesnyk M. Yu.
Published: March 2023

Aim. To assess the condition of renal function in hypertensive men in conditions of disorders of purine and carbohydrate metabolism
Material and methods. 60 male patients (aged from 18 to 65 years) with stage I–II of arterial hypertension (AH) and purine and carbohydrate metabolism disorders were examined. In these patients, the level of uric acid (UA) in daily urine, fractional excretion of UA, creatinine in daily urine, microalbumin in urine and the cystatin C level were determined. Hemodynamics was studied by daily blood pressure monitoring. Assessment of kinetics and deformation of the myocardium in offline mode using the Xstrain software package integrated into the ultrasound device (Esaote, Italy) was made. Patients were divided into 2 clinical groups – 1 group of AH with hyperuricemia, 2 – AH without uricemia. Statistical analysis of the results was performed using the Statistica 13.0 software package (Statsoft, USA).
Results. Correlation analysis in group 1 showed a positive correlation of cystatin C with the average daytime systolic blood pressure (SBP) (r = 0.408) and the variability of diastolic blood pressure (DBP) at night (r = 0.405), urinary microalbumin with the average SBP at night (r = 0.390) and average pulse blood pressure (r = 0.402), LV posterior wall thickness (r = 0.438), LV myocardial mass index (r = 0.621), end-diastolic index (EDI) (r = 0.492), end-systolic index (ESI) (r = 0.426), LV anterior-posterior size (r = 0.385). A negative correlation was established between blood serum SC and ejection fraction (EF) of the LV (r = -0.410), urinary microalbumin with cardiac index (SI) (r = -0.555) and the speed of movement of the lateral (e’ lat) part of the annulus fibrosus mitral valve (r = -0.453).
Conclusions. As a result of the studies, the negative influence of hyperuricemia and hyperglycemia in patients with AH on renal function was established. These changes were evidenced by an increase in microalbuminuria level, a decrease in the fractional excretion of UA, an increasing the serum UA level, remodeling of the myocardium, and worsening of the heart systolic function, worsening of the daily blood pressure profile.
Rapid productivity prediction method for frac hits affected wells based on gas reservoir numerical simulation and probability method
Authors: Nie Jie , Wang Hao , Hao Yuexiang
Published: March 2023

As an important unconventional resource, shale gas can alleviate energy shortage, and its efficient development ensures the long-term growth of oil and gas. The prediction of production levels and estimated ultimate recovery with high accuracy is necessary for shale gas development. Conventional methods are widely applied in the oil and gas industry owing to their simplicity and effectiveness; however, none of them can accurately predict the results for frac hits affected wells. In this work, a probability method based on the numerical model of shale gas reservoir has been formed. In view of the impact of frac hits on the productivity of production wells during the development of shale gas reservoirs, an embedded discrete fractured numerical simulation method for gas reservoirs is proposed to simulate the geological engineering parameter range of wells before frac. And aiming at the established numerical model of shale gas reservoir, this method adopts the ensemble smoother with multiple data assimilation automatic history matching technology to carry out the history matching process of the model. Based on the probability theory and numerical simulation results, this study analyses the influence of different distribution functions of parameters on the calculation results of reserves, and obtains the expected curve of reserves through combination calculation. Besides, the effectiveness of this method was verified by comparing with other traditional predicted method.
A Fatigue Method in the Tension-Compression Axial Stress Control Test of Automotive Sheet Steel
Authors: Su Hongying , Gao Yifei , Lu Yanpeng , Hu Zhiping , Liu Rendong , Lin Li , Xu Xin , Lv Dong , Lu Xiaofeng , Cao Zheng
Published: March 2023

Focused on the common problem of easy buckling of specimens in the tension-compression axial stress control fatigue test of automobile sheet steel, a stress fatigue test method for thickness less than 2.5 mm was proposed. For two kinds of automobile sheet materials with different strength levels and thicknesses, fatigue specimens with different widths of test section, parallel lengths, and fillet radii are designed. Without the anti-buckling device, high-cycle fatigue tests with a stress ratio Rs = −1 at different stress levels were carried out, and the shape and size of the fatigue specimens of automobile sheet materials were determined by the number of fatigue life cycles of specimens with different sizes under the same stress cycle form. The results show that for automobile sheet steel with a thickness of 1.0–2.5 mm, the recommended sizes of the uniform-gauge fatigue specimens are width of test section w = (1–3) t, parallel length Lp = (1–3) w, and fillet radius r = (3–10) t. For automobile sheet steel with a thickness less than 1 mm, because the time-displacement curve jitters during the test, it is recommended to install an anti-buckling device, specifically the anti-buckling device with mortise and tenon structure by self-design and with a flattop structure recommended by ISO 1099-2017, Metallic Materials—Fatigue Testing—Axial Force-Controlled Method.
The Therapeutic Relationship: Intrapsychic and Behavioral Changes in Both Patient and Analyst
Authors: Glucksman Myron L.
Published: March 2023

This article explores how the therapeutic relationship facilitates intrapsychic and behavioral changes in both the patient and the analyst. Key elements of the therapeutic relationship are reviewed, including transference, countertransference, introjective and projective identification, as well as the “real relationship.” Special attention is paid to the “transformative relationship,” which is a special kind of bond that develops between analyst and patient that is unique and transformative. It consists of mutual respect, emotional intimacy, trust, understanding, and affection. Empathic attunement is a key element in the evolution of a transformative relationship. This attunement optimally promotes intrapsychic and behavioral changes in both the patient and the analyst. This process is illustrated by a case presentation.
Lymphomatoid Granulomatosis: A Diagnostic Challenge
Authors: Ammannagari Nischala , Gao Zhijie , Deng Changchun , Connor Owen O’
Published: March 2023

Lymphomatoid granulomatosis is a rare Epstein barr virus associated lymphoma. It most commonly involves lungs, skin, central nervous system and kidneys. When lungs are involved, it often mimics common pulmonary conditions like pneumonia, making diagnosis extremely challenging. We present one such interesting case of Lymphomatoid granulomatosis in an immunocompetent young man.