bluuebunny/crossref_metadata_2025 huggingface dataset:
Ordovician deep dolomite reservoirs in the intracratonic Ordos Basin, China: Depositional model and Diagenetic evolution
Authors: Chen Anqing , Xu Shenglin , Yang Shuai , Chen Hongde , Su Zhongtang , Zhong Yijiang , Hu Sihan
Published: May 2018

Recent natural gas discoveries indicate that non-karstification-dominated reservoirs exist in the intracratonic Ordos Basin. This study examines the sedimentological and geochemical characteristics needed to clarify the depositional model and diagenetic evolution process of this newly discovered reservoir type. The depositional environment of the dolomite reservoir can be characterized as a tidal flat that grew from the Central Paleo-uplift to the eastern depression by cyclic progradation on an epeiric platform. A tidal flat sequence can extend laterally as a progradational wedge in each cycle of sea level fluctuation. The sheet-shaped peritidal shoal facies associations patched on the wedge represent potential dolomite reservoirs and can be recognized by the presence of doloarenite that has been altered into a vaguely relict grained-texture by diagenesis. Although continuing destructive diagenesis has led to reservoir densification, burial dolomitization and burial dissolution with facies selectivity have tended to occur in peritidal shoal facies associations, thus improving the quality of the dolomite reservoirs. These models provide new insights for targeting deep dolomite hydrocarbon reservoirs in intracratonic basins.
National political elites, the EU, and the populist challenge
Authors: Conti Nicolò
Published: May 2018

For several years, the European Union (EU) has faced two major crises at the same time – a global financial crisis that spilled over to the Eurozone countries and an immigration crisis. Those countries more negatively affected complain that the EU is ineffective in providing solutions, while better-off countries are reluctant to share the costs of the most exposed countries. In this critical context, radical populist parties have had specific incentives to offer extreme policy stances on the EU, signalling clear Eurosceptical positions as a means of breaking into the electoral market; their stance is now represented in the national parliament of many member states. The article examines the attitudes of national political elites towards the EU. It shows that the feelings towards the EU have largely survived acute changes (induced by the crises or changes to elite composition). Although Euroscepticism is a growing phenomenon within society and party systems, it is less on the rise among the elites holding public office. However, due to the unprecedented success of radical populist parties in some countries, Euroscepticism is now on the rise, also among this segment of elites, and some limited signs of contagion to the mainstream are already visible.
Hybrid media and populist currents in Ireland’s 2016 General Election
Authors: Suiter Jane , Culloty Eileen , Greene Derek , Siapera Eugenia
Published: May 2018

Populism, or at the very least a ‘populist zeitgeist’ has advanced across the globe with populist actors from across the ideological spectrum at the forefront of politics in Europe, North and South America and Southeast Asia. One of the major components is the media and specifically hybrid media, which can inhibit or magnify populist political tendencies among both parties and voters. We utilised both hand-coded traditional media data and machine learning on social media data in order to disengage the hybrid media nuances for populist storytelling. We find that the media system in Ireland largely inhibits populist politics and messaging and thereby dampens all anti-out-group messaging. Thus, contrary to the literature identifying an inclination towards populism in some types of new media, and the emergence of media populism in similar media systems in the United States and the United Kingdom, we find that the Irish media, across all platforms, tend not to focus on populist messaging. In addition, the norms appear to bleed over to social media. These results are important because they potentially provide lessons for other European countries in covering populist actors and they contribute to a more nuanced understanding of the role of different kinds of media in the representation of populist politics.
Extracorporeal membrane oxygenation support in individuals with thoracic insufficiency
Authors: Hancock Shelley , Froehlich Curtis , Armijo-Garcia Veronica , Meyer Andrew D.
Published: May 2018

Introduction:

Respiratory failure is the leading cause of mortality in individuals with congenital spine and rib deformities. We present a case report of a child with Jeune syndrome surviving respiratory failure using extracorporeal membrane oxygenation (ECMO). We also summarize thoracic insufficiency syndrome cases reported in the Extracorporeal Life Support Organization (ELSO) registry.

Case Report:

A two-year-old male with a chest circumference less than a third percentile for age was admitted with influenza pneumonia developing a peak oxygenation index of 103.5. The child survived to baseline pulmonary function after nine days of venous-arterial ECMO support.

Discussion:

The ELSO registry contained 27 individuals with a surrogate diagnosis of thoracic insufficiency (0.05%). There was no significant difference in survival to discharge for thoracic insufficiency patients (52%) compared to a previously healthy population supported with ECMO.

Conclusion:

ECMO is safe and may be effective in supporting individuals with thoracic insufficiency.
Lethal disseminated tuberculosis in patients under biological treatment – two clinical cases and a short review
Authors: Dantes Elena , Tofolean Doina Ecaterina , Fildan Ariadna Petronela , Craciun Liviu , Dumea Elena , Tofolean Ioan Tiberiu , Mazilu Laura
Published: May 2018

Tumour necrosis factor (TNF)-α inhibitors are highly used in Romania for the treatment of autoimmune disorders, such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, and ankylosing spondylitis. Biological therapy using TNF-α inhibitors is very effective but is associated with an increased risk of opportunistic infections, including active tuberculosis. Here, two cases are presented of patients with RA and psoriasis under biological therapy who developed very aggressive forms of disseminated tuberculosis, with a rapid progression to death. The authors conclude that patients undergoing biological therapy require thorough evaluation prior to initiating treatment, followed by continuous and rigorous monitoring by a multidisciplinary team during biological treatment, particularly in countries with a high incidence of tuberculosis.
The contribution of occupational therapy to building a dementia-positive community
Authors: Maki Yohko , Endo Hidetoshi
Published: May 2018

Statement of context

In this practice analysis, occupational therapists analysed the difficulties of social instrumental activities of daily living in people with dementia based on examples from their individual practice, and then developed a practical tool to support people with dementia in various settings.

Critical reflection on practice

People with dementia should be recognised as equal contributors to society. The results of this study can be used as an educational tool for raising awareness of dementia and expanding community support for people living with dementia.

Implications for practice

Occupational therapists can contribute to building dementia-positive communities, and this will empower people with dementia to reconnect to society.
Investigation on the performances of a twin arm tensioning device
Authors: di Napoli Maria , Galluzzi Renato , Zenerino Enrico C , Tonoli Andrea , Amati Nicola
Published: May 2018

In the present work, an experimental analysis of the performances of a twin arm tensioner is conducted. The investigated device is used in an automotive belt drive system mounting a belt starter generator. This configuration represents the latest trend of micro-hybrid technologies and is devoted to keep the tension of the belt within a reasonable range, while obtaining the highest possible efficiency in both motor and generator modes. At first, the functionality of a twin arm tensioner is investigated with a static model. Afterward, the performances of a real tensioner are experimentally assessed through a dedicated test rig in quasi-static conditions. The system is benchmarked in terms of angular displacement of the tensioner arms, belt tensions on the corresponding spans, and sliding arc in different operating conditions. Finally, experimental and simulation results are compared. It is shown that the proposed static model is able to capture the behavior of the real device and highlight its functionality.
Innovating urinary catheter design: An introduction to the engineering challenge
Authors: Murphy Cathy
Published: May 2018

Every day, people around the world rely on intermittent and indwelling urinary catheters to manage bladder dysfunction, but the potential or actual harm caused by these devices is well-recognised. Current catheter designs can cause urinary tract infection and septicaemia, bladder and urethral trauma and indwelling devices frequently become blocked. Furthermore, the devices can severely disrupt users’ lives, limiting their daily activities and can be costly to manage for healthcare providers. Despite this, little significant design innovation has taken place in the last 80 years. In this article current catheter designs and their limitations are reviewed, common catheter-associated problems are outlined and areas of design ripe for improvement proposed. The potential to relieve the individual and economic burden of catheter use is high.
Molecular mechanism for the influence of gender dimorphism on alcoholic liver injury in mice
Authors: Li S-Q , Wang P , Wang D-M , Lu H-J , Li R-F , Duan L-X , Zhu S , Wang S-L , Zhang Y-Y , Wang Y-L
Published: May 2018

It is known that women develop alcoholic liver injury more rapidly and have a lower alcohol toxic threshold than men. However, the detailed molecular mechanisms remain unclear. The precise mechanism responsible for the sex difference needs to be determined. Female and male mice were given ethanol by intragastric infusion every day for 4 weeks. The pathological changes were detected by hematoxylin–eosin, Sirius red, oil red O, periodic acid–Schiff, and Hochest33258 staining in the liver of female and male mice. The related gene and protein expression of hepatocytes stress, proliferation and apoptosis, glycogen synthesis, lipid metabolism, and hepatic fibrosis were also systematically analyzed in the female and male mice. Livers from ethanol-treated female mice had more serious hepatocyte necrosis, liver fibrosis ( P < 0.01), substantial micro/macrovesicular steatosis ( p < 0.01), glycogen consumption ( p < 0.05), and hepatocytes apoptosis ( p < 0.05) than ethanol-treated male mice. The expression of heat shock protein 27 (HSP27), HSP70, proliferating cell nuclear antigen, B-cell lymphoma/leukemia-2 (Bcl-2), and phosphorylated signal transducer and activators of transcription 3 (p-STAT3) was higher in ethanol-treated male mice than ethanol-treated female mice ( P < 0.05 or P < 0.01). But, the expression of Bax (Bcl-2-associated X protein), Caspase 3, CYP2E1 (cytochrome P4502E1), and transforming growth factor βl had the contrary results. Our study suggested that ethanol treatment induced more expression of HSP27 and HSP70, faster hepatocyte proliferation, higher level of glycogen, and interleukin-6 signaling pathway activation, but less hepatocyte apoptosis and CYP2E1 expression in male mice than female mice, which could be helpful to understand the molecular mechanism for the influence of sex difference on alcoholic liver injury.
Analysis of the Blood Viscosity Behavior in the Sicilian Study on Juvenile Myocardial Infarction
Authors: Caimi Gregorio , Hopps Eugenia , Montana Maria , Andolina Giuseppe , Urso Caterina , Canino Baldassare , Lo Presti Rosalia
Published: May 2018

Considering the role of hemorheology in coronary circulation, we studied blood viscosity in patients with juvenile myocardial infarction. We examined whole blood viscosity at high shear rate using the cone-on-plate viscosimeter Wells-Brookfield ½ LVT and at low shear rate employing a viscometer Contraves LS30 in 120 patients (aged <46 years) with myocardial infarction, at the initial stage and subsequently 3 and 12 months after. At the initial stage, patients had an increased whole blood viscosity in comparison to normal controls. This hemorheological profile was not influenced by the cardiovascular risk factors, nor by the extent of coronary lesions, even if some differences were evident between patients with ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI). The blood viscosity pattern at the initial stage did not influence recurring ischemic events or the onset of heart failure during an 18 months’ follow-up. The neutrophil to lymphocyte ratio did not affect the blood viscosity pattern. We reevaluated 83 patients 3 months after and 70 patients 12 months after the acute coronary syndrome, and we found that the hemorheological parameters were still altered in comparison to normal controls at both times. We observed an impairment of the hemorheological pattern in young patients with myocardial infarction, partially influenced by the infarction type (STEMI and NSTEMI) and persisting in the long term.
Using Machine Learning to Advance Personality Assessment and Theory
Authors: Bleidorn Wiebke , Hopwood Christopher James
Published: May 2018

Machine learning has led to important advances in society. One of the most exciting applications of machine learning in psychological science has been the development of assessment tools that can powerfully predict human behavior and personality traits. Thus far, machine learning approaches to personality assessment have focused on the associations between social media and other digital records with established personality measures. The goal of this article is to expand the potential of machine learning approaches to personality assessment by embedding it in a more comprehensive construct validation framework. We review recent applications of machine learning to personality assessment, place machine learning research in the broader context of fundamental principles of construct validation, and provide recommendations for how to use machine learning to advance our understanding of personality.
When rivers go to court: The Anthropocene in organization studies through the lens of Jacques Rancière
Authors: Kalonaityte Viktorija
Published: May 2018

The overarching purpose of this article is to add to the theorization of the Anthropocene in organization studies by investigating how long-term planetary concerns can be better accounted for in organizing. To do so, the article draws on the scholarship of Jacques Rancière to show how the dichotomy of nature and culture shapes the dominant framings of organizing, and to outline premises for artistic, scholarly and political interventions into the status quo that could aid the process of making our entanglements with the geo-biophysical politically viable. The article concludes that the Anthropocene can add to a renewal of organizational and political decision-making processes through a radical rethinking of the liberal humanist separation of nature and culture and related concepts such as democracy and political subjecthood.
Parent perspectives of neonatal tele-homecare: A qualitative study
Authors: Garne Holm Kristina , Brødsgaard Anne , Zachariassen Gitte , Smith Anthony C , Clemensen Jane
Published: May 2018

Introduction

Neonatal homecare for preterm infants is a method of supporting families and monitoring infant growth in the home setting. Telehealth may be used to deliver specialist neonatal care remotely, using online communication methods. This study explored parental experiences with neonatal tele-homecare (NTH).

Methods

Semi-structured interviews were conducted with 49 parents whose preterm infants had received NTH from a neonatal intensive care unit (NICU) in Denmark. Interview transcripts were analysed using Malterud’s systematic text condensation.

Results

Parents experienced NTH as a personalised method for linking to specialist staff in the NICU. NTH promoted the parent’s role as the primary care provider, further strengthening the parent–infant relationship.

Discussion

From the perspective of parents with preterm infants requiring specialist care, NTH is a useful method of supporting families in the home. Telehealth provides effective communication links with NICU specialists and encourages family-centred care.
Beyond Autocracy Promotion: A Review
Authors: Yakouchyk Katsiaryna
Published: May 2018

In this article, I provide a survey of the recent and rapidly growing theoretical and empirical literature on autocracy promotion. In a relatively concise way, the reader is able to grasp all key concepts and related aspects on the topic. This article is a guide for all those aiming to begin their journey in the scholarly land of autocracy promotion, trying to stimulate these travelers in exploring off-beaten research avenues.
An experimental study on the rotational accuracy of variable preload spindle-bearing system
Authors: Hu Gaofeng , Gao Weiguo , Chen Ye , Zhang Dawei , Tian Yanling , Qi Xiangyang , Zhang Hongjie
Published: May 2018

The rotational performance of the spindle-bearing system has critical influence upon the geometric shape and surface roughness of the machined parts. The effects of preload and preload method on the rotational performance of the spindle-bearing system is explored experimentally to reveal the role of preload and preload method in spindle rotational performances under different speeds. A test rig on which both the rigid preload and elastic preload can be realized, equipped with variable preload spindle-bearing system, is developed. Based on the mechanical model, the relationship of the axial preload and negative axial clearance of the spindle-bearing system is provided. Rotating sensitive radial error motion tests are conducted for evaluating synchronous and asynchronous radial errors of the variable preload spindle-bearing system under different rotating speeds and preload methods. The change regularity of synchronous and asynchronous radial errors with preloads under different rotating speeds are given. The results show that the preload plays an important role on the rotational performance of spindle-bearing system. The rigid preload is more efficient in achieving better rotational performance than elastic preload under the same rotating speed. Furthermore, this article significantly guides the preload designing and assembling of the new spindle-bearing system.
Bimanual control strategies
Authors: Wang Chaoyi , Shea Charles H
Published: May 2018

Two tasks (A and B) were designed which required participants to sequentially move through four target positions in a Lissajous display. Task A was designed so that participants could complete the task using either unimanual or bimanual control strategies. Task B was designed so that participants could complete the task using relatively simple or more complex bimanual control strategies. The purpose of this study was to determine which control strategy the participant utilises to complete the two tasks when Lissajous displays are provided and to determine the degree to which the size of the targets influences the control strategy chosen under these conditions. The movement amplitude between two adjacent targets and the target size resulted in an Index of Difficulty (ID) of 2 and 4 for each task. For both tasks, participants practised 15 trials (30 s per trial) for each ID and then was administered a test trial. The results for both Tasks A and B indicated that the ID2 condition resulted in a circular path, whereas the ID4 condition resulted in a straight-line path on the Lissajous plot. This suggests that at the low ID condition participants produced a continuous 1:1 with 90° phase offset bimanual coordination pattern. At the high ID condition, the participants consistently chose to switch to a more stable unimanual left and right movements in Task A and to transition between in-phase and anti-phase bimanual coordination patterns in Task B. In addition, both limbs’ movements were more harmonic in the low ID condition than in the high ID condition.
Antisense oligonucleotides in neurological disorders
Authors: Wurster Claudia D. , Ludolph Albert C.
Published: May 2018

The introduction of genetics revolutionized the field of neurodegenerative and neuromuscular diseases and has provided considerable insight into the underlying pathomechanisms. Nevertheless, effective treatment options have been limited. This changed recently when antisense oligonucleotides (ASOs) could be translated from in vitro and experimental animal studies into clinical practice. In 2016, two ASOs were approved by the United States US Food and Drug Administration (FDA) and demonstrated remarkable efficacy in Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA). ASOs are synthetic single-stranded strings of nucleic acids. They selectively bind to specific premessenger ribonucleic acid (pre-mRNA)/mRNA sequences and alter protein synthesis by several mechanisms of action. Thus, apart from gene replacement, ASOs may therefore provide the most direct therapeutic strategy for influencing gene expression. In this review, we shall discuss basic mechanisms of ASO action, the role of chemical modifications needed to improve the pharmacodynamic and pharmacokinetic properties of ASOs, and we shall then focus on several ASOs developed for the treatment of neurodegenerative and neuromuscular disorders, including SMA, DMD, myotonic dystrophies, Huntington’s disease, amyotrophic lateral sclerosis and Alzheimer’s disease.
Application of Machine Learning to Predict Dietary Lapses During Weight Loss
Authors: Goldstein Stephanie P. , Zhang Fengqing , Thomas John G. , Butryn Meghan L. , Herbert James D. , Forman Evan M.
Published: May 2018

Background:

Individuals who adhere to dietary guidelines provided during weight loss interventions tend to be more successful with weight control. Any deviation from dietary guidelines can be referred to as a “lapse.” There is a growing body of research showing that lapses are predictable using a variety of physiological, environmental, and psychological indicators. With recent technological advancements, it may be possible to assess these triggers and predict dietary lapses in real time. The current study sought to use machine learning techniques to predict lapses and evaluate the utility of combining both group- and individual-level data to enhance lapse prediction.

Methods:

The current study trained and tested a machine learning algorithm capable of predicting dietary lapses from a behavioral weight loss program among adults with overweight/obesity (n = 12). Participants were asked to follow a weight control diet for 6 weeks and complete ecological momentary assessment (EMA; repeated brief surveys delivered via smartphone) regarding dietary lapses and relevant triggers.

Results:

WEKA decision trees were used to predict lapses with an accuracy of 0.72 for the group of participants. However, generalization of the group algorithm to each individual was poor, and as such, group- and individual-level data were combined to improve prediction. The findings suggest that 4 weeks of individual data collection is recommended to attain optimal model performance.

Conclusions:

The predictive algorithm could be utilized to provide in-the-moment interventions to prevent dietary lapses and therefore enhance weight losses. Furthermore, methods in the current study could be translated to other types of health behavior lapses.
São Tomé Island Endemic Treefrogs (Hyperolius spp.) and Land-Use Intensification: A Tale of Hope and Caution
Authors: Strauß Lena , Faustino de Lima Ricardo , Riesbeck Frank , Rödel Mark-Oliver
Published: May 2018

Forest degradation is a major driver of the global biodiversity declines. However, responses to forest degradation vary greatly between taxa and are predominantly understudied. This study investigates the effects of land-use change on the endemic amphibian fauna of São Tomé Island (Central Africa), where a fast-growing human population increases pressure on forest resources. We sampled acoustic data on reed frog ( Hyperolius spp.) abundance at eight transects in each of four land-use categories, representing different levels of forest degradation: old-growth forest, secondary forest, agroforest, and horticulture. While Hyperolius molleri was most abundant in secondary forest and horticulture, Hyperolius thomensis was almost exclusively found in agroforest. We interpret these differences based on reproductive traits, since both species deposit terrestrial eggs and have aquatic larvae, but reproduce in different microhabitats. H. molleri utilizes open water bodies bordered by vegetation for calling and oviposition, which human disturbance has made available in secondary forest and horticulture. In contrast, H. thomensis breeds in water-filled tree holes (phytotelmata), which predominantly occurred in agroforest, often within coral trees ( Erythrina spp.). This first study on Santomean amphibian abundances revealed that H. molleri and H. thomensis males exhibit distinct nonlinear responses to forest degradation and may reap some benefit from human habitat alteration. However, despite their apparent tolerance to some anthropogenic disturbance, further land-use intensification may reduce overall habitat suitability for these and other endemic species.
Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes?
Authors: Rubeor Amity , Goojha Carmen , Manning Jeffrey , White Jordan
Published: May 2018

Context:

Supplementing iron-deficient nonanemic (IDNA) athletes with iron to improve performance is a trend in endurance sports.

Objectives:

To investigate the benefits of iron on performance, identify a ferritin level cutoff in IDNA athletes, and determine which iron supplementation regimens are most effective.

Data Sources:

A search of the PubMed, CINAHL, Embase, ERIC, and Cochrane databases was performed in 2014 including all articles. Citations of pertinent review articles were also searched. In 2017, the search was repeated.

Study Selection:

Inclusion criteria comprised studies of level 1 to 3 evidence, written in the English language, that researched iron supplementation in nonanemic athletes and reported performance outcomes.

Study Design:

Systematic review.

Level of Evidence:

Level 3.

Data Extraction:

The search terms used included athletic performance, resistance training, athletes, physical endurance, iron, iron deficiency, supplement, non-anemic, low ferritin, ferritin, ferritin blood level, athletes, and sports.

Results:

A total of 1884 studies were identified through the initial database search, and 13 were identified through searching references of relevant review articles. A subsequent database search identified 46 studies. Following exclusions, 12 studies with a total of 283 participants were included. Supplementing IDNA athletes with iron improved performance in 6 studies (146 participants) and did not improve performance in the other 6 studies (137 participants). In the 6 studies that showed improved performance with iron supplementation, all used a ferritin level cutoff of ≤20 μg/L for treatment. Additionally, all studies that showed improved performance used oral iron as a supplement.

Conclusion:

The evidence is equivocal as to whether iron supplementation in IDNA athletes improves athletic performance. Supplementing athletes with ferritin levels <20 μg/L may be more beneficial than supplementing athletes with higher baseline ferritin levels.
Chondral Delamination of Fresh Osteochondral Allografts after Implantation in the Knee: A Matched Cohort Analysis
Authors: Rauck Ryan C. , Wang Dean , Tao Matthew , Williams Riley J.
Published: May 2018

Introduction

Delamination of the chondral surface of an osteochondral allograft (OCA) from the underlying cancellous bone has been described as a mode of failure after implantation in the knee. Our hypothesis was that increased storage time of the OCA is associated with increased risk of graft delamination after implantation.

Methods

Prospective data on 13 patients with evidence of OCA delamination identified on magnetic resonance imaging or during subsequent surgery from 2000 to 2015 were reviewed. A cohort of 33 patients without evidence of graft delamination were then matched to the delamination group based on recipient age, sex, body mass index (BMI), and chondral defect location. The matched cohort size was established based on a power calculation for determining differences in OCA storage times. All patients had a minimum 2-year follow-up.

Results

There was no difference in donor age, donor sex, and graft storage time between groups (30 vs. 31 days, P = 0.78). There were no differences between number of previous ipsilateral knee surgeries (1.8 vs. 0.84, P = 0.26), BMI (26.8 vs. 25.0 kg/m2, P = 0.31), total chondral defect size (6.5 vs. 5.8 cm2, P = 0.41) or preoperative Marx activity scores between groups.

Conclusion

There is no association between OCA storage time, activity level scores, or number of previous ipsilateral knee surgeries and graft delamination in our patient population. Further work is needed to identify the etiology for this mode of failure of OCAs.
Phosphoramidates and phosphonamidates (ProTides) with antiviral activity
Authors: Slusarczyk Magdalena , Serpi Michaela , Pertusati Fabrizio
Published: May 2018

Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in 1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in many laboratories. Designed with aim to overcome limitations and the key resistance mechanisms associated with nucleoside analogues used in the clinic (poor cellular uptake, poor conversion to the 5′-monophosphate form), the ProTide approach has been successfully applied to a vast number of nucleoside analogues with antiviral and anticancer activity. ProTides consist of a 5′-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5′-monophosphate, which is further transformed to the active 5′-triphosphate form of the nucleoside analogue. In this review, the seminal contribution of Chris McGuigan’s research to this field is presented. His technology proved to be extremely successful in drug discovery and has led to two Food and Drug Administration-approved antiviral agents.
Cardiogenic shock complicating peripartum cardiomyopathy: Importance of early left ventricular unloading and bromocriptine therapy
Authors: Sieweke Jan-Thorben , Pfeffer Tobias Jonathan , Berliner Dominik , König Tobias , Hallbaum Maximiliane , Napp L Christian , Tongers Jörn , Kühn Christian , Schmitto Jan D , Hilfiker-Kleiner Denise , Schäfer Andreas , Bauersachs Johann
Published: May 2018

Introduction:

Acute peripartum cardiomyopathy complicated by cardiogenic shock is a rare but life-threatening disease. A prolactin fragment is considered causal for the pathogenesis of peripartum cardiomyopathy. This analysis sought to investigate the role of early percutaneous mechanical circulatory support with micro-axial flow-pumps and/or veno-arterial extracorporeal membrane oxygenation in combination with the prolactin inhibitor bromocriptine in refractory cardiogenic shock complicating peripartum cardiomyopathy.

Methods and results:

In this single-centre analysis, five peripartum cardiomyopathy patients with refractory cardiogenic shock received mechanical circulatory support with either Impella CP microaxial pump only ( n=2) or in combination with veno-arterial extracorporeal membrane oxygenation ( n=3) in the setting of biventricular failure. All patients were mechanically ventilated. In all cases mechanical circulatory support was combined with bromocriptine therapy and early administration of levosimendan. All patients survived the acute phase of refractory cardiogenic shock. Mechanical circulatory support using a micro-axial pump allowed to significantly reduce catecholamine dosage. Remarkably, early left ventricular support with micro-axial flow-pumps resulted in myocardial recovery whereas delayed Impella (mechanical circulatory support) implantation was associated with poor left ventricular recovery.

Conclusion:

Mechanical circulatory support in patients with refractory cardiogenic shock complicating peripartum cardiomyopathy was associated with a 30-day survival of 100% and a favourable outcome. Notably, early left ventricular unloading combined with bromocriptine therapy was associated with left ventricular recovery. Therefore, an immediate transfer to a tertiary hospital experienced in mechanical circulatory support in combination with bromocriptine treatment seems indispensable for successful treatment of peripartum cardiomyopathy complicated by cardiogenic shock.
Delayed photosensitivity in a child with erythropoietic protoporphyria : a case report
Authors: Kiberd James , Finlayson Laura
Published: May 2018

Erythropoietic protoporphyria (EPP) is a genetically inherited disease that causes protoporphyrin accumulation in erythrocytes, skin, liver, bile, and stool. Clinically this manifests as photosensitivity with painful, edematous cutaneous porphyria. We present the case of a four-year-old boy with a delayed photosensitivity reaction to sunlight. In the evening following sun exposure, he would develop swelling and a violaceous rash on the dorsal surface of his hands and occasionally the helix of his ears. His reactions were severe, requiring morphine on more than one occasion prior to diagnosis. He later developed waxy depressed scars on his nose and cheeks. On laboratory investigation, both total and free protoporphyrin were elevated. Photosensitivity in EPP usually occurs minutes after sun exposure, but our patient had significantly delayed reactions. Genetic testing revealed mutation in the FECH gene that confirmed the diagnosis of EPP. Although rare, presentations of photosensitivity in the pediatric population should be carefully evaluated.
Management of Nursing Workplace Incivility in the Health Care Settings: A Systematic Review
Authors: Armstrong Nancy
Published: May 2018

Workplace incivility is a well-documented issue in nursing in the health care setting. It has the potential to cause emotional and physical distress in victims and potentially affects the quality of care provided. The purpose of this study was to critique and summarize the most recent, available evidence related to interventions in assisting nursing staff working in health care settings in managing incivility. This systematic review of literature yielded 10 studies meeting the criteria. The studies were mostly identified as lower quality research. Despite the lower quality of research, the collection of evidence suggests the use of a combination of educational training about workplace incivility, training about effective responses to uncivil workplace behaviors, and active learning activities to practice newly learned communication skills, in assisting nurses in improving their ability to manage incivility in the workplace.
Relationships of Musculoskeletal Symptoms, Sociodemographics, and Body Mass Index With Leisure-Time Physical Activity Among Nurses
Authors: Nam Soohyun , Song MinKyoung , Lee Soo-Jeong
Published: May 2018

Nurses have a high prevalence of musculoskeletal symptoms from patient handling tasks such as lifting, transferring, and repositioning. Comorbidities such as musculoskeletal symptoms may negatively affect engagement in leisure-time physical activity (LTPA). However, limited data are available on the relationship between musculoskeletal symptoms and LTPA among nurses. The purpose of this study was to describe musculoskeletal symptoms and LTPA, and to examine the relationships of musculoskeletal symptoms, sociodemographics, and body mass index with LTPA among nurses. Cross-sectional data on sociodemographics, employment characteristics, musculoskeletal symptoms, body mass index, and LTPA were collected from a statewide random sample of 454 California nurses from January to July 2013. Descriptive statistics, bivariate and multiple logistic regressions were performed. We observed that non-White nurses were less likely to engage in regular aerobic physical activity than White nurses (odds ratio [OR] = 0.61; 95% confidence interval [CI] = [0.40, 0.94]). Currently working nurses were less likely to engage in regular aerobic physical activity than their counterparts (OR = 0.48; 95% CI = [0.25, 0.91]). Nurses with higher body mass index were less likely to perform regular aerobic physical activity (OR = 0.93; 95% CI = [0.89, 0.97]) or muscle-strengthening physical activity (OR = 0.92; 95% CI = [0.88, 0.96]). This study found no evidence that musculoskeletal symptoms may interfere with regular engagement in LTPA. Physical activity promotion interventions should address employment-related barriers, and particularly target racial minority nurses and those who have a high body mass index.
The Relationship Between Self-Regulatory Strategies, Daily Stress, and Negative Affect in College Females: An Analysis of Typical Levels and Intraindividual Variability
Authors: Russell Alissa , Anderson Samantha F.
Published: May 2018

Emerging adults exist in a highly transitional time during which they juggle many short-term and long-term goals, all while adjusting to greater independence. This independence may require enhanced personal motivation and self-regulation for successful goal attainment. In the present study, 88 college women reported their use of three self-regulatory strategies (goal commitment, lowering aspirations, and positive reappraisal), then reported current negative affect (NA) and stress thrice daily for 1 week. Results of multilevel modeling demonstrate that goal commitment is associated with significantly reduced intraindividual variability in NA across time points, and lowering aspirations is associated with significantly increased variability. A nonsignificant trend demonstrated that individuals who reported greater use of reappraisal strategies also demonstrated marginally significantly less NA on high-stress occasions. Results inform understanding of self-regulatory development and point toward effective areas of intervention for emerging adults struggling during the transition to college.
The Rockwood classification in acute acromioclavicular joint injury does not correlate with symptoms
Authors: Granville-Chapman J , Torrance E , Rashid A , Funk L
Published: May 2018

Purpose:

Rockwood classified acromioclavicular (AC) joint injuries by displacement of the joint on radiographs. This classification has driven the management dogma of acute AC dislocation. The correlation between Rockwood grade and symptoms has not been described in acute injury. This study assesses that relationship.

Methods:

This series included 77 patients with acute AC joint injury (<6 weeks), treated between 2006 and 2015. Objective and patient-reported measures enabled correlation between clinical measures and Rockwood grade.

Results:

The mean age was 32 years (±11.86; range 17–59 years); 88% were male. Forty-four per cent were professional athletes and 43% suffered injury during rugby. The mean time from injury to presentation was 2 weeks (±1.64; range 0–5 weeks). There was poor correlation between Rockwood classification and pain (visual analogue scale) ( rs = 0.05; p = 0.752). Poor correlation was noted between Rockwood grade and functional deficit (elevation ( rs = 0.18; p = 0.275), abduction ( rs = 0.19; p = 0.246) and strength ( rs = 0.09; p = 0.579) vs. contralateral side). Oxford and Constant scores did not correlate with Rockwood grade ( rs = 0.13; p = 0.972 and 0.01; p = 0.448, respectively).

Conclusion:

The Rockwood grade does not correlate with clinical symptoms in acute AC joint injury. Previous evidence demonstrates the Rockwood classification’s limitations in predicting the structures injured. Therefore, the reliability of using the Rockwood grade as a decision-making tool in the management of acute AC joint dislocation is unclear.
Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Hybrid Grafts in Patients Over 40 Years of Age: Comparisons Between Different Age Groups
Authors: Nishio Yusuke , Kondo Eiji , Onodera Jun , Onodera Tomohiro , Yagi Tomonori , Iwasaki Norimasa , Yasuda Kazunori
Published: May 2018

Background:

Several recent studies have reported that favorable clinical results and a high level of patient satisfaction can generally be obtained with no increased risk of complications after single-bundle anterior cruciate ligament (ACL) reconstruction performed in patients >40 years of age. However, no studies have yet clarified the age-based differences in clinical outcomes after double-bundle reconstruction.

Purpose:

To compare clinical outcomes after double-bundle ACL reconstruction using hamstring tendon hybrid grafts between patients in 2 different age groups: ≥40 years and <40 years.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A retrospective study was conducted using 96 patients (48 men, 48 women ; mean age, 37 years) who underwent unilateral ACL reconstruction between 2008 and 2011. These patients were divided into 2 groups: group M included patients ≥40 years of age (n = 40 patients), and group Y included patients <40 years of age (n = 56 patients). All patients underwent the same anatomic double-bundle ACL reconstruction procedure. Clinical outcomes were evaluated at 2 years after surgery. Tunnel enlargement was also evaluated by computed digital radiography at 1 week and 2 years after surgery.

Results:

Mean postoperative side-to-side differences in anterior laxity were 0.5 ± 1.9 mm and 1.2 ± 1.5 mm in groups M and Y, respectively; there was a significant difference between the 2 groups ( P = .039). There were no significant differences between the groups in Lysholm knee scores, International Knee Documentation Committee (IKDC) scores, or peak muscle torque of the hamstring. On the other hand, peak muscle torque of the quadriceps was significantly lower in group M (81%) than in group Y (89%) ( P = .025). With respect to femoral tunnel enlargement, the posterolateral tunnel in group M was significantly larger than that in group Y on anteroposterior and lateral radiographs ( P = .015 and P = .002, respectively).

Conclusion:

Equivalent clinical outcomes were seen between the 2 age groups after double-bundle ACL reconstruction. Postoperative anterior laxity was significantly less in older patients than in younger patients, however, older patients had significantly less quadriceps muscle strength than younger patients. Surgeons should be aware of residual muscle weakness and tunnel enlargement when performing double-bundle ACL reconstruction in older patients.
Healthy, Wealthy, and Wise? Exploring Parent Comparative Optimism About Future Child Outcomes
Authors: Wright Davene R. , Christakis Dimitri A. , Lozano Paula , Saelens Brian E.
Published: May 2018

Objectives. Comparative optimism is present in parental predictions of their child’s long-term, obesity-related health outcomes and some of this optimism is unrealistic. An understanding of how comparative optimism relates to parents’ predictions of health versus other child outcomes could contribute to the development of interventions and strategies pediatricians can use to improve risk assessment. Methods. In a nationally representative survey, we asked American parents of 6- to 17-year-old children ( n = 410) to estimate the chances that their child and “a typical child in their community” would be affected by overweight, get married, and complete a 4-year college degree by age 30, and the child’s future salary at age 30. We collected data on family demographic and health characteristics. We modeled the difference in parent predictions for their child versus the typical child using multivariate linear regressions. Results. Compared to the typical child, parents were less likely to predict that their child would be affected by overweight (−26.6 percentage points, 95% confidence interval [CI]: −35.6, −17.7) and more likely to predict that their child would complete a 4-year degree (16.7 percentage points, 95% CI: 2.5, 31.0). Parents predicted their child would have a higher income than the typical child at age 30 ($15,266, 95% CI: $7,487, $23,046). Parents did not predict that their child would be more likely than the typical child to be married by age 30 (−2.2 percentage points, 95% CI: −8.1, 3.7). Conclusions. Some parents appear to exhibit comparative optimism around their child’s future weight status, education, and economic outcomes, but not marriage. Future experimental work should assess whether risk communication approaches that consider optimism bias influence parent risk perception and parenting behaviors.
Tensile strength of graphene versus temperature and crack size: Analytical expressions from molecular dynamics simulation data
Authors: Giannopoulos Georgios I , Avntoulla Giorgos S
Published: May 2018

Graphene, the strongest known material, is significantly influenced by the loading conditions, the environmental temperature and the existence of internal imperfections and discontinuities such as cracks. Higher temperatures lead to higher atomic kinetic energies and easier failure of graphene while even a one atom vacancy may cause a dramatic reduction in its strength. The aim of the present study is to describe analytical expressions which associate the tensile strength of the monolayer graphene with the temperature and the length of a possible centrally positioned, straight crack. For this reason, molecular dynamics simulations are conducted to compute all the necessary numerical data. Then special equations are developed by fitting the computed data into appropriate non-linear regression surfaces. The proposed non-linear analytical equations are capable of straightforwardly predicting the strength of graphene given the chirality, the temperature and the size of the center crack under investigation.
Fabrication and characterization of polymethyl methacrylate microchannel using dry and underwater CO2 laser
Authors: Helmy Mohamed O , Fath El-Bab Ahmed R , El-Hofy Hassan A
Published: May 2018

Over the last few decades, miniaturization has become the key aspect of driving evolution of modern technology. The CO2 laser is an inexpensive, flexible, and fast device for fabricating microfluidic chips. Thermal damages associated with such a process are considered the big challenge for microfluidic device developers. This article evaluates the quality of polymethyl methacrylate microchannels fabricated by the CO2 laser. Experiments were conducted in the air (dry) and underwater by leaving a thin water layer on the top surface of the polymethyl methacrylate substrate. The effect of laser power and scanning speed on performance characteristics, such as the microchannel aspect ratio, surface roughness, and heat-affected zone was studied. Taguchi’s experimental design with grey relational analysis was used for multi-objective optimization of the laser micromachining parameters. Analysis of variance was also employed to determine the most significant control factors that affect the microchannel quality. The results indicated that the cooling effect of the underwater method has a significant effect on decreasing the extent of thermal damage while increasing the aspect ratio. Laser power is the most significant factor on the performance characteristics followed by scanning speed and pulse rate. Grey relational analysis is efficient in selecting the optimum conditions regarding the performance characteristics.