bluuebunny/crossref_metadata_2025 huggingface dataset:
Much ado about nothing: inapplicable data as insertion–deletion events
Authors: Wheeler Ward C.
Published: July 2023

The treatment of inapplicable characters has proved especially vexing to systematists. Investigators have wrestled with alternative coding scenarios to capture both the presence and absence of a feature, and its variation when present, in a reasonable manner. Three basic issues have presented themselves: (i) impossible states at internal nodes; (ii) action at a distance among disparate parts of the tree; and (iii) “secondary” (i.e. aspect variation) characters overwhelming “primary” (i.e. character presence/absence) patterns in grouping taxa. Multiple methods have been proposed to deal with these issues in the context of standard character coding with varying levels of complexity. Here, I show that these issues can be dealt with in a direct fashion by treating presence/absence not as a character, but as insertion/deletion of a character with all its potential variation. This approach removes these three problems in simple, straightforward manner.
Peripheral atherosclerosis evaluation through ultrasound: A promising diagnostic tool for coronary artery disease
Authors: Artyszuk Łukasz , Błażejowska Ewelina , Danielecka Zuzanna , Jurek Jonasz , Olek Ewa , Abramczyk Piotr
Published: July 2023

Effective treatment, but also proper diagnosis of cardiovascular diseases, remains a major challenge in everyday practice. A quick, safe, and economically acceptable non‐invasive procedure should play a leading role in cardiovascular risk assessment before invasive diagnostics is performed. The staging of subclinical atherosclerosis may help in further clinical decisions. Safe, widely available, and relatively inexpensive, ultrasonography is a promising examination that should find wider application in clinical practice. The latest ESC guidelines emphasize the usefulness of carotid ultrasound in the diagnosis of coronary artery disease (CAD) and subclinical assessment of atherosclerosis, which help to determine the level of cardiovascular risk. Ultrasound examination of peripheral arteries, especially superficial vessels such as the femoral arteries, is quite easy, quick, and accurate. Other vascular beds, such as iliac and renal, are more demanding to examine, but can also provide valuable information. This review summarizes important studies comparing the severity of atherosclerosis in ultrasound‐visible vascular beds in patients with established CAD. We especially emphasize the benefits of the combined assessment of atherosclerosis features, which were characterized by high sensitivity and specificity in the diagnosis of CAD and other serious cardiovascular diseases.
Experimental Analysis of the Leakage Characteristics of Three Types of Annular Segmented Seals
Authors: Fourt Erwan , Arghir Mihai , Jolly Pascal , Andasmas Mohamed
Published: July 2023

The present paper presents an experimental analysis of the leakage characteristics of three kinds of segmented seals. The segments of the first seal have smooth pads while the second seal has pads with pockets. The pads of the third seal are smooth but the rotor is textured with inclined grooves. The pockets or the textures lift the segments from the rotor and create a radial clearance. This is reflected by the leakage flow rate, the friction torque, and the seal's temperature. These characteristics are hereby measured on a dedicated test rig. The presented results are dimensionless, the measured values for the three types of seal types being divided by the same maximum value. This makes it possible to compare the performance of different segmented seal technologies and to evaluate the compromise between low leakage and enhanced lifespan. The assumptions made on the opening of the segmented seal with pockets during the tests are finally verified with a simple analytical model.
Using opinion dynamics to identify groups for targeted intervention in lifelong learning: A case study of SkillsFuture in Singapore
Authors: Lim Zhi Yong , Munshi Tahir , Yap Jun Hong , Mishra Ankit , Lai Joel Weijia , Yeo Darren J. , Cheong Kang Hao
Published: July 2023

In this paper, we explore the use of opinion dynamics models to examine changes in opinions of lifelong learning, and to identify groups of people for targeted intervention to improve their reception to lifelong learning. This method has a multitude of potential applications related to clustering and segmentation. Singapore’s initiative for lifelong learning, SkillsFuture, serves as a case study for the application of the technique. We first found a positive correlation between how motivated people are to learn and a negative correlation between how much people know about SkillsFuture opportunities, with respect to their reception to SkillsFuture courses. Then, we used an opinion dynamics model to model the evolution of opinions to produce clusters of people whose opinions will converge. The clusters were then grouped into three groups: those with the largest increase, largest decrease and a middle group. Further examining the covariates of the people in each cluster (e.g., age, last drawn salary, etc.), we propose organizing sharing sessions for the group with the largest increase, intervention for the group with the largest decrease, and gathering more information about the motivations of the middle group.
Supplementary Table S1 from HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation
Authors: Grigoryan Hasmik , Imani Partow , Sacerdote Carlotta , Masala Giovanna , Grioni Sara , Tumino Rosario , Chiodini Paolo , Dudoit Sandrine , Vineis Paolo , Rappaport Stephen M.
Published: July 2023

Supplementary Table S1: Cancer types and morphology codes
Supplemental Table 2 from Cigarette and Alternative Tobacco Product Use among Adult Cancer Survivors Enrolled in 9 ECOG-ACRIN Clinical Trials
Authors: Streck Joanna M. , Lee Ju-Whei , Walter Angela Wangari , Rosen Rachel L. , Gareen Ilana F. , Kircher Sheetal Mehta , Herman Benjamin A. , Carlos Ruth C. , Kumar Shaji , Mayer Ingrid A. , Saba Nabil F. , Fenske Timothy S. , Neal Joel W. , Atkins Michael B. , Hodi F. Stephen , Kyriakopoulos Christos E. , Tempany Clare , Shanafelt Tait D. , Wagner Lynne I. , Land Stephanie R. , Park Elyse R. , Ostroff Jamie S.
Published: July 2023

Supplemental Table 2 shows associations of baseline continuous participant characteristics with past 30-day tobacco product use
Supplementary Figure S2 from HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation
Authors: Grigoryan Hasmik , Imani Partow , Sacerdote Carlotta , Masala Giovanna , Grioni Sara , Tumino Rosario , Chiodini Paolo , Dudoit Sandrine , Vineis Paolo , Rappaport Stephen M.
Published: July 2023

Supplementary Figure S2: Plots of ln(case/matched-control fold change) versus time to diagnosis (ttd) in days from recruitment for adduct features selected for MALES and FEMALES
Table S5 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Supplementary Table S5 shows the summary of known colorectal risk loci that are located in our CCFR and GECCO datasets.
Figure S4 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Supplementary Figure S4 shows how DEPTH common risk regions are defined.
Figure S1 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Supplementary Figure S1 showing the flow chart of the analyses for identifying novel, unique, and common risk regions from DEPTH and logistic regression analyses.
Supplementary Table 2 from Impact of Frontline Ivosidenib on Volumetric Growth Patterns in Isocitrate Dehydrogenase–mutant Astrocytic and Oligodendroglial Tumors
Authors: Kamson David Olayinka , Puri Sushant , Sang Yingying , Shi Meihui Jessica , Blair Lindsay , Blakeley Jaishri O. , Laterra John
Published: July 2023

Supplementary Table 2 - Raw data for growth modeling.
Table S4 from Results of an Open-label, Phase Ia/b Study of Pembrolizumab plus Olaratumab in Patients with Unresectable, Locally Advanced, or Metastatic Soft-Tissue Sarcoma
Authors: Schöffski Patrick , Bahleda Rastislav , Wagner Andrew J. , Burgess Melissa A. , Junker Niels , Chisamore Michael , Peterson Patrick , Szpurka Anna M. , Ceccarelli Matteo , Tap William D.
Published: July 2023

Table S4: Representativeness of Study Participants.
Table S3 from Results of an Open-label, Phase Ia/b Study of Pembrolizumab plus Olaratumab in Patients with Unresectable, Locally Advanced, or Metastatic Soft-Tissue Sarcoma
Authors: Schöffski Patrick , Bahleda Rastislav , Wagner Andrew J. , Burgess Melissa A. , Junker Niels , Chisamore Michael , Peterson Patrick , Szpurka Anna M. , Ceccarelli Matteo , Tap William D.
Published: July 2023

Table S3: Pharmacokinetic parameters after a 60-minute IV infusion of olaratumab on Day 1 and Day 8 of Cycle 1 and Cycle 3 with pembrolizumab.
Figure S1 from Results of an Open-label, Phase Ia/b Study of Pembrolizumab plus Olaratumab in Patients with Unresectable, Locally Advanced, or Metastatic Soft-Tissue Sarcoma
Authors: Schöffski Patrick , Bahleda Rastislav , Wagner Andrew J. , Burgess Melissa A. , Junker Niels , Chisamore Michael , Peterson Patrick , Szpurka Anna M. , Ceccarelli Matteo , Tap William D.
Published: July 2023

Figure S1: Study design.
Supplementary Figure S3 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: July 2023

Genomic landscape of the whole cohort
Supplementary Data S9 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: July 2023

Supplementary Data 9 describes the results from OncoSIgnal analysis.
Supplemental Figure 7 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Authors: Jiang Haowen , He Clifford Jiajun , Li Albert M. , He Bo , Li Yang , Zhou Meng-Ning , Ye Jiangbin
Published: July 2023

S7. Mitochondrial uncoupling inhibits reductive carboxylation in spheroid culture.
Supplemental Figure 3 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Authors: Jiang Haowen , He Clifford Jiajun , Li Albert M. , He Bo , Li Yang , Zhou Meng-Ning , Ye Jiangbin
Published: July 2023

S3. Mitochondrial uncoupler FCCP and BAM5 inhibit reductive carboxylation.
Supplemental Figure 4 from Allele-specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–mutant Endometrial Cancer
Authors: Blanchard Zannel , Rush Craig M. , Arnesen Spencer , Vahrenkamp Jeffery M. , Rodriguez Adriana C. , Jarboe Elke A. , Brown Callie , Chang Matthew E.K. , Flory Mark R. , Mohammed Hisham , Modzelewska Katarzyna , Lum David H. , Gertz Jason
Published: July 2023

ER mutants do not affect proliferation, but down-regulate proteins associated with movement and impact migration
Supplemental Figure 2 from Allele-specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–mutant Endometrial Cancer
Authors: Blanchard Zannel , Rush Craig M. , Arnesen Spencer , Vahrenkamp Jeffery M. , Rodriguez Adriana C. , Jarboe Elke A. , Brown Callie , Chang Matthew E.K. , Flory Mark R. , Mohammed Hisham , Modzelewska Katarzyna , Lum David H. , Gertz Jason
Published: July 2023

Comparison of mutant ER regulated genes and genes regulated by sustained estrogen signaling
Supplemental Figure 1 from Allele-specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–mutant Endometrial Cancer
Authors: Blanchard Zannel , Rush Craig M. , Arnesen Spencer , Vahrenkamp Jeffery M. , Rodriguez Adriana C. , Jarboe Elke A. , Brown Callie , Chang Matthew E.K. , Flory Mark R. , Mohammed Hisham , Modzelewska Katarzyna , Lum David H. , Gertz Jason
Published: July 2023

Validation and gene expression analysis of ER mutant models
Supplementary Table 6 from LncRNA-Encoded Micropeptide ACLY-BP Drives Lipid Deposition and Cell Proliferation in Clear Cell Renal Cell Carcinoma via Maintenance of ACLY Acetylation
Authors: Zhang Shenghua , Zhang Zheng , Liu Xiaolong , Deng Yibin , Zheng Jian , Deng Jieqiong , Wang Yirong , Guo Binbin , Li Fanrong , Chen Xiaoyue , Pan Yacheng , Wang Jieyu , Lu Jiachun , Wu Siqi , Guo Qiang , Zhou Yifeng
Published: July 2023

The genomic position of the predicted ORFs of the six lncRNAs
Supplementary Table 4 from LncRNA-Encoded Micropeptide ACLY-BP Drives Lipid Deposition and Cell Proliferation in Clear Cell Renal Cell Carcinoma via Maintenance of ACLY Acetylation
Authors: Zhang Shenghua , Zhang Zheng , Liu Xiaolong , Deng Yibin , Zheng Jian , Deng Jieqiong , Wang Yirong , Guo Binbin , Li Fanrong , Chen Xiaoyue , Pan Yacheng , Wang Jieyu , Lu Jiachun , Wu Siqi , Guo Qiang , Zhou Yifeng
Published: July 2023

Sequences of shRNAs and siRNAs used in this study
Supplementary Table S2 from Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Authors: Gupta Harshath , Inoue Hitoshi , Nakai Yasutomo , Nakayama Masashi , Jones Tracy , Hicks Jessica L. , Kumar Balasubramanian , Gurel Meltem , Nelson William G. , De Marzo Angelo M. , Yegnasubramanian Srinivasan
Published: July 2023

Supplementary Table S2 shows the phased methylation of the GSTP1 promoter region across 102 lesions classified by density of methylation.
Supplementary Figure S2 from Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Authors: Gupta Harshath , Inoue Hitoshi , Nakai Yasutomo , Nakayama Masashi , Jones Tracy , Hicks Jessica L. , Kumar Balasubramanian , Gurel Meltem , Nelson William G. , De Marzo Angelo M. , Yegnasubramanian Srinivasan
Published: July 2023

Supplementary Figure S2 shows the methylation rate by allele of the GSTP1 promoter region for partially methylated PIN alleles and demonstrates a hotspot of methylation around transcription factor binding sites and the transcription start site.
Supplementary Video: HPV and Heterocateny from Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration
Authors: Akagi Keiko , Symer David E. , Mahmoud Medhat , Jiang Bo , Goodwin Sara , Wangsa Darawalee , Li Zhengke , Xiao Weihong , Dunn Joe Dan , Ried Thomas , Coombes Kevin R. , Sedlazeck Fritz J. , Gillison Maura L.
Published: July 2023

Video explaining the heterocateny model and summarizing the main findings of the paper.
Supplementary Table S2 from RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations
Authors: Subbiah Vivek , Sahai Vaibhav , Maglic Dejan , Bruderek Kamil , Touré B. Barry , Zhao Songping , Valverde Roberto , O'Hearn Patrick J. , Moustakas Demetri T. , Schönherr Heike , Gerami-Moayed Nastaran , Taylor Alexander M. , Hudson Brandi M. , Houde Damian J. , Pal Debjani , Foster Lindsey , Gunaydin Hakan , Ayaz Pelin , Sharon Dina A. , Goyal Lipika , Schram Alison M. , Kamath Suneel , Sherwin Cori Ann , Schmidt-Kittler Oleg , Jen Kai Yu , Ricard Fabien , Wolf Beni B. , Shaw David E. , Bergstrom Donald A. , Watters James , Casaletto Jessica B.
Published: July 2023

Biochemical inhibition of FGFR by RLY-4008 and pan-FGFRi
Supplementary Table S2 from Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Authors: Kan Winnie L. , Dhagat Urmi , Kaufmann Kerstin B. , Hercus Timothy R. , Nero Tracy L. , Zeng Andy G.X. , Toubia John , Barry Emma F. , Broughton Sophie E. , Gomez Guillermo A. , Benard Brooks A. , Dottore Mara , Cheung Tung Shing Karen S. , Boutzen Héléna , Samaraweera Saumya E. , Simpson Kaylene J. , Jin Liqing , Goodall Gregory J. , Begley C. Glenn , Thomas Daniel , Ekert Paul G. , Tvorogov Denis , D'Andrea Richard J. , Dick John E. , Parker Michael W. , Lopez Angel F.
Published: July 2023

Summary of the key interactions in the IL-3R ternary complex in the IL-3R ternary complex crystal structure.
Figure S6 from Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Authors: Kan Winnie L. , Dhagat Urmi , Kaufmann Kerstin B. , Hercus Timothy R. , Nero Tracy L. , Zeng Andy G.X. , Toubia John , Barry Emma F. , Broughton Sophie E. , Gomez Guillermo A. , Benard Brooks A. , Dottore Mara , Cheung Tung Shing Karen S. , Boutzen Héléna , Samaraweera Saumya E. , Simpson Kaylene J. , Jin Liqing , Goodall Gregory J. , Begley C. Glenn , Thomas Daniel , Ekert Paul G. , Tvorogov Denis , D'Andrea Richard J. , Dick John E. , Parker Michael W. , Lopez Angel F.
Published: July 2023

Increasing IL3Rα/βc ratios lead to hexameric receptor assembly and augmented quiescence.
Figure S3 from Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Authors: Kan Winnie L. , Dhagat Urmi , Kaufmann Kerstin B. , Hercus Timothy R. , Nero Tracy L. , Zeng Andy G.X. , Toubia John , Barry Emma F. , Broughton Sophie E. , Gomez Guillermo A. , Benard Brooks A. , Dottore Mara , Cheung Tung Shing Karen S. , Boutzen Héléna , Samaraweera Saumya E. , Simpson Kaylene J. , Jin Liqing , Goodall Gregory J. , Begley C. Glenn , Thomas Daniel , Ekert Paul G. , Tvorogov Denis , D'Andrea Richard J. , Dick John E. , Parker Michael W. , Lopez Angel F.
Published: July 2023

IL3Rα P248 at the IL-3R assembly interface is critical for cell differentiation.
Figure S2 from Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Authors: Kan Winnie L. , Dhagat Urmi , Kaufmann Kerstin B. , Hercus Timothy R. , Nero Tracy L. , Zeng Andy G.X. , Toubia John , Barry Emma F. , Broughton Sophie E. , Gomez Guillermo A. , Benard Brooks A. , Dottore Mara , Cheung Tung Shing Karen S. , Boutzen Héléna , Samaraweera Saumya E. , Simpson Kaylene J. , Jin Liqing , Goodall Gregory J. , Begley C. Glenn , Thomas Daniel , Ekert Paul G. , Tvorogov Denis , D'Andrea Richard J. , Dick John E. , Parker Michael W. , Lopez Angel F.
Published: July 2023

Key interactions between distinct residues in the IL-3R ternary complex crystal structure.
Supplementary Table 6 from Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
Authors: Yadavilli Sapna , Waight Jeremy D , Brett Sara , Bi Meixia , Zhang Tianqian , Liu Yao-Bin , Ellis Catherine , Turner David C , Hahn Ashleigh , Shi Hong , Seestaller-Wehr Laura , Jing Junping , Xie Qing , Shaik Jafar Sadik , Ji Xiao , Gagnon Robert , Fieles William , Hook Laura , Grant Steven , Hopley Stephanie , DeYoung M. Phillip , Blackwell Christina , Chisamore Michael , Biddlecombe Robert , Figueroa David J , Hopson Christopher B , Srinivasan Roopa , Smothers James , Maio Michele , Rischin Danny , Olive Daniel , Paul Elaine , Mayes Patrick A. , Hoos Axel , Ballas Marc
Published: July 2023

Example TIL marker expression phenotypes from clinical patient
case studies of feladilimab monotherapy and in combination with pembrolizumab.
Supplementary Excel File 1 from Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: July 2023

Quantification of immunoblots.
Figure S3 from Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: July 2023

Gene set enrichment analysis.
Supplementary Table S2 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W
Published: July 2023

Supplementary Table S2
Supplementary Figure S5 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W
Published: July 2023

Supplementary Figure S5. GPER knockdown in MOLM14 Western blot of GPER knockdown clones of MOLM14 cells.
Supplementary Figure 5 from Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
Authors: Yadavilli Sapna , Waight Jeremy D , Brett Sara , Bi Meixia , Zhang Tianqian , Liu Yao-Bin , Ellis Catherine , Turner David C , Hahn Ashleigh , Shi Hong , Seestaller-Wehr Laura , Jing Junping , Xie Qing , Shaik Jafar Sadik , Ji Xiao , Gagnon Robert , Fieles William , Hook Laura , Grant Steven , Hopley Stephanie , DeYoung M. Phillip , Blackwell Christina , Chisamore Michael , Biddlecombe Robert , Figueroa David J , Hopson Christopher B , Srinivasan Roopa , Smothers James , Maio Michele , Rischin Danny , Olive Daniel , Paul Elaine , Mayes Patrick A. , Hoos Axel , Ballas Marc
Published: July 2023

Feladilimab induces phospho-AKT in ICOS-expressing Ba/F3
cells and cytokine production in PBMC from healthy donors and cancer patients.
Supplementary Figure 4 from Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
Authors: Yadavilli Sapna , Waight Jeremy D , Brett Sara , Bi Meixia , Zhang Tianqian , Liu Yao-Bin , Ellis Catherine , Turner David C , Hahn Ashleigh , Shi Hong , Seestaller-Wehr Laura , Jing Junping , Xie Qing , Shaik Jafar Sadik , Ji Xiao , Gagnon Robert , Fieles William , Hook Laura , Grant Steven , Hopley Stephanie , DeYoung M. Phillip , Blackwell Christina , Chisamore Michael , Biddlecombe Robert , Figueroa David J , Hopson Christopher B , Srinivasan Roopa , Smothers James , Maio Michele , Rischin Danny , Olive Daniel , Paul Elaine , Mayes Patrick A. , Hoos Axel , Ballas Marc
Published: July 2023

Uncropped gel images
Supplementary Figure 12 from Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
Authors: Yadavilli Sapna , Waight Jeremy D , Brett Sara , Bi Meixia , Zhang Tianqian , Liu Yao-Bin , Ellis Catherine , Turner David C , Hahn Ashleigh , Shi Hong , Seestaller-Wehr Laura , Jing Junping , Xie Qing , Shaik Jafar Sadik , Ji Xiao , Gagnon Robert , Fieles William , Hook Laura , Grant Steven , Hopley Stephanie , DeYoung M. Phillip , Blackwell Christina , Chisamore Michael , Biddlecombe Robert , Figueroa David J , Hopson Christopher B , Srinivasan Roopa , Smothers James , Maio Michele , Rischin Danny , Olive Daniel , Paul Elaine , Mayes Patrick A. , Hoos Axel , Ballas Marc
Published: July 2023

Clinical case studies of feladilimab monotherapy and in
combination with pembrolizumab.
Supplementary Figure 11 from Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
Authors: Yadavilli Sapna , Waight Jeremy D , Brett Sara , Bi Meixia , Zhang Tianqian , Liu Yao-Bin , Ellis Catherine , Turner David C , Hahn Ashleigh , Shi Hong , Seestaller-Wehr Laura , Jing Junping , Xie Qing , Shaik Jafar Sadik , Ji Xiao , Gagnon Robert , Fieles William , Hook Laura , Grant Steven , Hopley Stephanie , DeYoung M. Phillip , Blackwell Christina , Chisamore Michael , Biddlecombe Robert , Figueroa David J , Hopson Christopher B , Srinivasan Roopa , Smothers James , Maio Michele , Rischin Danny , Olive Daniel , Paul Elaine , Mayes Patrick A. , Hoos Axel , Ballas Marc
Published: July 2023

Clinical case study of feladilimab monotherapy.
Supplementary Figure S11 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W
Published: July 2023

(A and C) Representative DCF histograms of (A) U937 and (C) MOLM14 cells treated with 250nM LNS8812 or 250nM LNS8801 at indicated time points. (B and D) Summary graph of median fluorescence intensity (MFI) of (B) U937 and (D) MOLM14 cells treated with 250nM LNS8812 or 250nM LNS8801. 3 replicates were analyzed per condition. Statistical analysis was done via one-way ANOVA with multiple comparisons was used for panels B and D (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).
Supplementary Figure S10 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W
Published: July 2023

Supplementary Figure S10. LNS8801 induces cell death independently of the classical secreted death ligands (A) Time course western blot of U937 cells treated with 250nM LNS8801. (B) Annexin V staining flow analysis of U937 cells treated with either 20ng/mL TNF⍺, 10ug/mL TNFR1 antibody, or 250nM LNS8801. Cells were incubated for 72 hours. 3 replicates were used per condition. (C) Annexin V staining flow analysis of U937 cells treated with LNS8801-treated U937 conditioned media. Cells were incubated in conditioned media for 72 hours. 3 replicates were used per condition. One-way ANOVA was used for statistical analysis (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).
Table S1, Table S2 from A Th1-like CD4+ T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Authors: Yanagihara Akitoshi , Yamasaki Satoshi , Hashimoto Kosuke , Taguchi Ryo , Umesaki Tetsuya , Imai Hisao , Kaira Kyoichi , Nitanda Hiroyuki , Sakaguchi Hirozo , Ishida Hironori , Kobayashi Kunihiko , Horimoto Katsuhisa , Kagamu Hiroshi
Published: July 2023

Table S1. List of antibodies used for CyTOF.

Table S2. Differentially expressed genes between Th7R cluster and Th1 cluster in tumor-infiltrating lymphocytes.
Supplementary Video 4 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Video 4
Supplementary Video 3 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Video 3
Supplementary Video 2 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Video 2
Supplementary Video 1 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Video 1
Supplementary Tables 1-7 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Tables
Supplementary Methods from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Methods
Supplementary Figure 1 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Fig. 1 shows Differentially expressed gene signature (DEGs) based on next gene sequencing (mRNA sequencing) for ARLow /mCRPC/NEPC (PC-3, PC-3M, DU145) vs ARHigh /mCSPC (LNCaP, VCAP, 22RV1) prostate cancer (PCa) cell lines and normal prostate cell lines RWPE1 and RWPE2. Volcano plots representing mRNA expression for all cell lines. (blue p<0.05 and gray>0.05) HeatMap representing Differentially Expressed Gene Signature (DEGs) for ARLow/mCRPC/NEPC (PC-3, PC-3M, DU145) vs ARHigh/mCSPC (LNCaP, VCAP, 22RV1) PCa and normal prostate cell lines RWPE1 and RWPE2 (FDR<0.05 and TOP-100).
Data from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: July 2023

Despite recent therapeutic advances, the 5-year survival rate for adults with acute myeloid leukemia (AML) is poor and standard-of-care chemotherapy is associated with significant toxicity, highlighting the need for new therapeutic approaches. Recent work from our group and others established that the G protein-coupled estrogen receptor (GPER) is tumor suppressive in melanoma and other solid tumors. We performed a preliminary screen of human cancer cell lines from multiple malignancies and found that LNS8801, a synthetic pharmacologic agonist of GPER currently in early phase clinical trials, promoted apoptosis in human AML cells. Using human AML cell lines and primary cells, we show that LNS8801 inhibits human AML in preclinical in vitro models, while not affecting normal mononuclear cells. Although GPER is broadly expressed in normal and malignant myeloid cells, this cancer-specific LNS8801-induced inhibition appeared to be independent of GPER signaling. LNS8801 induced AML cell death primarily through a caspase-dependent apoptosis pathway. This was independent of secreted classical death receptor ligands, and instead required induction of reactive oxygen species (ROS) and activation of endoplasmic reticulum (ER) stress response pathways including IRE1α. These studies demonstrate a novel activity of LNS8801 in AML cells and show that targeting ER stress with LNS8801 may be a useful therapeutic approach for AML.
Significance:
Previous work demonstrated that LNS8801 inhibits cancer via GPER activation, especially in solid tumors. Here we show that LNS8801 inhibits AML via GPER-independent mechanisms that include ROS induction and ER activation.
Study of the knowledge of medical secrecy and the rationale for exempting a doctor from medical secrecy by the court - research article
Authors: Błotnicki Maciej , Ćwik-Błotnicka Dominika
Published: July 2023

Introduction: medical confidentiality is one of the basic rights of the patient and plays a key role in ensuring trust between doctor and patient. However, in a criminal trial, where there is a conflict between the protection of the patient's rights and the need for proper sentencing by the criminal court, the doctor may be exempted from medical confidentiality.

The aim of the study: was to illustrate the respondents' level of knowledge about medical confidentiality. The intention was also to find out the opinion of the respondents as to whether the court should have the right to exempt a doctor from medical secrecy and how often such a situation was encountered.

Material and method: A questionnaire of our own authorship was used. 223 people were surveyed. A comparison of answers to questions between subgroups was made. It was based on current criminal literature and court decisions.

Results: well acquainted with the subject is only 30%, and mostly those with medical or legal education. Nearly ¾ of the respondents believe that in exceptional situations the court should have the right to exempt a doctor from the obligation of medical secrecy.

Conclusions: as a result of the fact that almost 90% of those surveyed believe that most people are unaware of the rationale for exempting a doctor from the obligation of medical secrecy, this topic should be popularized in society. It must be emphasized that balancing the protection of professional secrecy with the needs of justice is a challenge that requires a comprehensive legal analysis in each case.
Current views on pathogenesis of rosacea
Authors: Barczak Iga , Bondos Borys , Kochan Robert , Barczuk Patryk , Bara Sebastian , Dzięgielewski Jędrzej , Bączek Kacper , Barć Jan , Gałajda Elżbieta , Antonik Jacek
Published: July 2023

Rosacea is a chronic inflammatory disease that usually affects the central part of the face. The primary symptoms include facial flushing, persistent erythema, telangiectasia,  inflammatory pustules and papules. Based on groups of these symptoms, four basic rosacea subtypes have been defined: erythematotelangiectatic, papulopustular, ocular, phymatous; and one variant, granulomatous rosacea. Although the pathophysiology of this disorder is not fully known, many components such as immune and neurovascular dysregulation, oxidative stress, genetic background, gut microbiome, skin microbiome as well as external aspects are thought to play a role. In this article, we present the main factors that are speculated to be involved in the pathogenesis of rosacea.
Methods and materials: We reviewed the literature available on PubMed and Google Scholar using the words "rosacea”, „rosacea pathogenesis”, „demodex”, „reactive oxygen species”, „rosacea microbiome”.
Summary
Rosacea is a chronic dermatosis whose etiology, despite many studies, is not fully understood. Currently, an abnormal inflammatory reaction caused by excessive stimulation of TLR-2 receptors is suspected as the main factor in the pathomechanism of the disease. Vascular disorders, transmission disorders, genetic factors, skin and intestinal dysbiosis also participate in the pathogenesis of rosacea. It is assumed that exogenous factors such as diet and exposure to UV radiation also play a role in the development of the disease.
Self-esteem, stress and anxiety among health care workers during the COVID-19 pandemic
Authors: Łaskawiec-Żuławińska Daria , Wlazło Marika , Grajek Mateusz , Szlacheta Patryk , Korzonek-Szlacheta Ilona
Published: July 2023

Introduction: The effects of the impact of the COVID-19 pandemic on the mental health of many individuals are now becoming increasingly apparent, especially among health care workers, who not infrequently develop the so-called post-pandemic stress syndrome, referring in essence to post-traumatic stress disorder. This is a consequence of the fact that medics, especially those who worked on the front lines during the pandemic experienced enormous challenges and difficulties every day that burdened and/or exceeded their individual abilities to adapt.

Purpose: The purpose of this study was to assess well-being and the incidence of stress and anxiety among health care workers during the COVID-19 pandemic.

Material and Methods: 182 people participated in the study, belonging to the representatives of medical personnel. The study used a questionnaire technique, by providing a survey with questions in electronic form. The survey consisted of both original questions and standardized psychometric tools, i.e. WHO-5, PSS-10, GAD-7.

Results: Based on the scales, 78.6% of respondents were found to have elevated levels of stress and anxiety with a concomitant decrease in well-being in relation to COVID-19 work.

Conclusions: Disturbing mental health implications were found among health care workers. Those surveyed showed elevated levels of experiencing anxiety and stress, as well as reduced well-being while working during the COVID-19 pandemic. To ensure optimal mental well-being among medical professionals, he recommends guaranteeing access to mental health support and assistance programs for health care workers.
Heavy metal content in duck eggs and meat that consumes feed containing Sapu-sapu fish (Hypostomus plecostomus)
Authors: ASNAWI ASNAWI
Published: July 2023

Abstract. Asnawi. 2023. Heavy metal content in duck eggs and meat that consumes feed containing Sapu-sapu fish (Hypostomus plecostomus). Biodiversitas 24: 3201-3206. This study aimed to evaluate heavy metals in the eggs and meat of ducks feeding on the Sapu-sapu fish (Hypostomus plecostomus Linnaeus, 1758) on Lombok Island, West Nusa Tenggara, Indonesia. The observation of collected Sapu-sapu fish samples from three major Mataram rivers. Duck eggs and meat were collected from a livestock group that fed Sapu-sapu fish. The observed variables include; macronutrients (moisture content, crude protein, crude fat, crude fiber, and ash) and heavy metal content (Cu and Pb) in the Sapu-sapu fish, duck meat and eggs fed by Sapu-sapu fish. The study found that the Sapu-sapu fish possesses complete macronutrients, making it a possible duck feed. The heavy metal content of copper (Cu) in the Sapu-sapu fish ranges from 189.314±0.0238 ppm, while the lead (Pb) content ranges from 4.25±0.18 ppm. The average heavy metal content of Cu in the eggs and meat of ducks consuming Sapu-sapu fish was 7.692±2.158 ppm and 14.523±6.481 ppm, while the levels of lead in eggs and meat of cesarean fish were 0.936±1.557 ppm 0.373±0.211 ppm. The study concluded that the Sapu-sapu fish in the Mataram city stream has a complete nutritional content (protein, fat, amino acids, minerals) but contains high heavy metals. Therefore, if consumed, ducks dispose of it into the eggs and duck meat. As a result, the eggs and meat of ducks that consume sapu-sapu fish contain heavy metals Cu and Pb that exceed the threshold, so they are unsafe for human consumption.
Resisting the Neoliberal Project in India: Punjab and the Struggle against Corporate Encroachment into Agriculture
Authors: Kaur Navpreet , Saratchand C.
Published: July 2023

The imposition of the Three Farm Laws by the union government of India in 2020 was intended to further corporate encroachment in agriculture. However, this resulted in an unprecedented resistance movement of farmers and workers. The union government of India eventually had to retreat, and the Three Farm Laws were repealed in 2021. In this article, we intend to briefly review with special reference to Punjab, the historical context of corporate encroachment into Indian agriculture, the unfolding of the resistance to this corporate encroachment, and a prognosis on the political economy of the neoliberal project in India.
Assessment of bioresources potential of a rural village for self energy generation
Authors: Khambalkar Vivek P. , Karale Dhiraj S. , Gadge Sharashchandra R. , Dahatonde Shilpa B.
Published: July 2023

The present research work assesses the bioenergy available in a rural village for self-sustainable development. The biomass consumption of the village for domestic as well as for all the activities has been collected. The study also entailed the collection of all bioenergy sources available in the village. The bioenergy sources, such as biomass available through forestry, agriculture waste and residues etc., and animal waste (animal dung), have been collected for the exact quantification of the bioenergy generation capacity of the village. From the study it has been found that the village has considerable bioenergy potential. The magnitude of the bioenergy density will help in achieving a self power-generating village. The bioenergy density will also help for the development of a bioenergy atlas for the particular location. A suitable renewable energy generation system in the studied village is being recommended.
DECISION TREES DO NOT LIE: CURIOSITIES IN PREFERENCES OF CROATIAN ONLINE CONSUMERS
Authors: Filipas Ana Marija , Vretenar Nenad , Prudky Ivan
Published: July 2023

Understanding consumers’ preferences has always been important for economic theory and for business practitioners in operations management, supply chain management, marketing, etc. While preferences are often considered stable in simplified theoretical modelling, this is not the case in real-world decision-making. Therefore, it is crucial to understand consumers’ preferences when a market disruption occurs. This research aims to recognise consumers’ preferences with respect to online shopping after the COVID-19 outbreak hit markets. To this purpose, we conducted an empirical study among Croatian consumers with prior experience in online shopping using an online questionnaire. The questionnaire was completed by 350 respondents who met the criteria. We selected decision-tree models using the J48 algorithm to determine the influences of the found shopping factors and demographic characteristics on a consumer’s preference indicator. The main components of our indicators that influence consumer behaviour are the stimulators and destimulators of online shopping and the importance of social incidence. Our results show significant differences between men and women, with men tending to use fewer variables to make decisions. In addition, the analysis revealed that four product groups and a range of shopping mode-specific influencing factors are required to evaluate consumers’ purchase points when constructing the consumers’ preference indicator.
MODERATING ROLE OF LEADER-MEMBER EXCHANGE IN THE EFFECT OF INNOVATIVE WORK BEHAVIOR ON TURNOVER INTENTION
Authors: Ulufer Kansoy Seçil
Published: July 2023

This study aims to determine whether leader-member exchange has a role in the effect of innovative work behavior on turnover intention. Innovative work behavior refers to the tendency of employees to engage in innovative actions such as making suggestions, generating new ideas, and improving work processes. Turnover intention represents an employee’s voluntary desire to turnover intention. Leader- member exchange refers to the factors such as leadership support, communication, and trust that influence employee commitment and performance within the organization. The hypotheses of the study were tested on 460 white-collar employees at companies. In the study, 3 scales were used: innovative work behavior scale, turnover intention scale, and leader-member exchange scale. The structural equation model was preferred for the study. As a result of the study, it was noted that innovative work behavior affected leader-member exchange positively and leader-member exchange had a low level of effect on innovative work behavior and turnover intention. Additionally, it was discovered that professional respect, as a sub-dimension of leader-member exchange, affected idea realization and idea generation directly and indirectly.