bluuebunny/crossref_metadata_2025 huggingface dataset:
Supporting rehabilitation practice for COVID-19 recovery: A descriptive qualitative analysis of healthcare worker perspectives.
Authors: Laake Tanis Van , Hitch Danielle
Published: June 2023

Objective The study aimed to explore the perspective of healthcare workers on the resources they need to provide quality rehabilitation for people recovering from COVID-19 infection.Methods A descriptive qualitative approach using reflexive thematic analysis was employed. Focus groups and interviews were performed with 9 healthcare workers (1 Intensive Care Unit Physiotherapist, 1 Respiratory Therapist and 7 Occupational Therapists) with experience treating patients recovering from COVID-19 infection within hospital and in the community. Verbatim transcripts were coded and analysed for themes.Results Healthcare workers perceive an urgent need for resources about recovery from COVID-19 infection to support quality care. They particularly want detailed guidance about potential trajectories of recovery, and what should be expected over time for people with Long COVID. Many observed that this group of patients required higher oxygen requirement and experienced slower recovery than others with serious respiratory conditions. Supports for quality care do exist but are not perceived as sufficient by participants. They want any new resources developed to be accessible, quick to access and targeted to specific healthcare worker roles and services settings. Participants identified several barriers to accessing practice supports, including the time poor nature of healthcare and financial costs to both patients and healthcare workers.Conclusion Healthcare workers perceive an urgent need for the development of resources to support quality rehabilitation for people recovering from COVID-19 infection, to support best outcomes for this group of patients. Any resources developed must consider identified barriers to their access and use to maximise their impact.
Cytotoxic effects of dimethyl-celecoxib (DMC) on bone tumor cell line MG63 and cell line HEK293
Authors: Naji Tahereh , Fatehi Maryam , Ahmadi Rahim , Ghahramani Morteza , Khalaji Mahla
Published: June 2023

Dimethyl-celecoxib (DMC), is a celecoxib (CXB) derivative has no inhibitory function on cyclooxygenase-2 (COX-2) and displays antitumor properties. This substance can be helpful in advancing the treatment of COX-2-indipentent cancers. In the current study, we assayed the efficacy of DMC on MG63 bone tumor cell line and Human embryonic kidney (HEK293) cell line. The cellular viability, nitrogen monoxide content, and Inducible nitric oxide synthases (iNOS) gene expression were measured respectively with MTT (The MTT assay is a colorimetric assay for assessing cell metabolic activity.) Griess reaction, and real-time Reverse transcription polymerase chain reaction (RT-PCR) procedures .IC50 was determined by MTT assay, and iNOS gene expression was evaluated by RT-PCR. Also, monoxide nitrogen production was monitored by a Griess test and finally one-way Anova (Analysis of Variance (ANOVA) is a statistical formula used to compare variances across the means (or average) of different groups.) and T-test were used to analyze the data. Results showed that Dimethylcelloxib at concentrations of: 62.5, 125, 250, 500 µg /ml at 48 h significantly decreased the survival rate of MG63 and HEK293 tumor cells (P < 0.001). It was found that iNOS gene expression decreased significantly (P < 0.001) and production of monoxide nitrogen molecule had a significant increase (P < 0.01 and P < 0.001). since Dimethylceloxib reduced iNOS gene expression, it was expected to decrease nitrogen monoxide, but this drug showed its cytotoxic effects through increased nitrogen monoxide production.
A window to the future: effects of climate change on the distribution patterns of Iranian Zygaenidae and their host plants
Authors: Noori Sajad , Hofmann Axel , Rödder Dennis , Husemann Martin , Rajaei Hossein
Published: June 2023

Climate change has been suggested as an important human-induced driver for the ongoing sixth mass extinction. As a common response to climate change, and particularly global warming, species move toward higher latitudes or shift uphill. Furthermore, rapid climate change impacts the biotic interactions of species. Especially, in Zygaenid moths which are highly specialized in both habitat and host plant preferences. Iranian Zygaenidae are relatively well-known and represent a unique fauna with a high endemism rate (46%) in the whole Palearctic; as such they are a good model to study the impact of climate change on future distributions. In this study, species distribution modeling (SDM) and ensembles of small models (ESMs) were used to investigate the impact of climate change on the future distribution of endemic and non-endemic species of zygaenids, as well as their larval host plants. Three different climate scenarios were applied to predict the probable responses of the species to different climate change intensities. Our results suggest that the central and southern parts of the country will be impacted profoundly by climate change compared to the northern regions. Beyond this, most endemic species will experience an altitudinal shift from their current range, while non-endemic species may move towards higher latitudes. Considering that the regions with higher diversity of zygaenids are limited to mountainous areas, mainly within the Irano-Anatolian biodiversity hotspot, the identification of their local high diversity regions for conservation practices has a high priority.
quantms: A cloud-based pipeline for proteomics reanalysis enables the quantification of 17521 proteins in 9,502 human samples.
Authors: Dai Chengxin , Pfeuffer Julianus , Wang Hong , Sachsenberg Timo , Demichev Vadim , Kohlbacher Oliver , Perez-Riverol Yasset
Published: June 2023

Public proteomics data is rapidly increasing, creating a computational challenge for large-scale reanalysis. Here, we introduce quantms, an open-source cloud-based pipeline for massively parallel proteomics data analysis. We used quantms to reanalyze 56 of the largest datasets, comprising 26801 instrument files from 9502 human samples, to quantify 17521 based on 1.02 million unique peptides. Based on standard file formats improves the reproducibility and deposition of the data to ProteomeXchange.
Fragmentation-induced localization and boundary charges in dimensions two and above
Authors: Lehmann Julius , Sala de Torres-Solanot Pablo , Pollmann Frank , Rakovszky Tibor
Published: June 2023

We study higher dimensional models with symmetric correlated hoppings, which generalize a one-dimensional model introduced in the context of dipole-conserving dynamics. We prove rigorously that whenever the local configuration space takes its smallest non-trivial value, these models exhibit localized behavior due to fragmentation, in any dimension. For the same class of models, we then construct a hierarchy of conserved quantities that are power-law localized at the boundary of the system with increasing powers. Combining these with Mazur’s bound, we prove that boundary correlations are infinitely long lived, even when the bulk is not localized. We use our results to construct quantum Hamiltonians that exhibit the analogues of strong zero modes in two and higher dimensions.
Green technology and energy consumption efficiency in Zimbabwe
Authors: Mukarati Julius , Jeke Leward , Sanderson Abel
Published: June 2023

Environmental pollution is one of the major problems that has become an increasing area of concern globally, leading to the emergence of green energy technology. Research has been conducted on green technology adoption mainly in developed countries. However, there is noticeably limited knowledge about technology adoption and energy consumption in developing countries, for example, Zimbabwe. Thus, this paper seeks to analyze the impact of green technology adoption on energy sector performance in Zimbabwe. The results established that green technology adoption, energy pricing, energy sector investment, and capital structure significantly influence energy consumption efficiency. These results showed a positive relationship between green technology adoption and energy consumption efficiency based on the argument of the substitution possibility effect between green technology and energy demand. The study recommends adopting and identifying the type of green technology to utilize and the timing of investment in green technology. In addition, alternative estimation methods can be adopted to test the robustness of the findings.
Evaluation of a multi-staged bias correction approach on CHIRP and CHIRPS rainfall product: a case study of the Lake Hawassa watershed
Authors: Beyene Tsegamlak Diriba , Zimale Fasikaw Atanaw , Gebrekristos Sirak Tekleab , Nedaw Dessie
Published: June 2023

A promising future development area to improve the accuracy of satellite rainfall estimates (SREs) is accessing merits from different sources of data through combining algorithms. The main objective of this study is to assess the accuracy and importance of the fused multistage approach of bias correction. Accordingly, two versions of resampled and spatially bias-corrected Climate Hazards Group Infrared Precipitation (CHIRP) estimates were merged with ground measurements using a conditional merging procedure. Results of applied performance measures (i.e. seven) on corrected and merged CHIRP SREs show that the Percent of Detection (POD) and Percent Volume Error (PVE) have improved. Depending on the combination of coupled stations for validation, up to 70 and 50% PVE improvement was achieved at some stations for wet and dry periods, respectively. Moreover, the bias-corrected and conditionally merged CHIRP SREs have outperformed the estimates by resampling CHIRP with station dataset (CHIRPS) over the sparsely populated western part of the watershed. However, the devised method was limited in considering dry-day events during bias correction, which in turn has affected the performance of the bias correction of the CHIRPS product. Finally, future research should concentrate on such methods of fusing to understand the benefits of various approaches and produce more precise rainfall records.
Novel Pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as Protein
Kinase C Inhibitors for Treating Diseases
Authors: De Surya K.
Published: June 2023

This patent describes the series of compounds and their pharmaceutically acceptable
salts, such as compound K7 (as a representative potent compound). These protein
kinase C selective inhibitors are useful for treating diabetes mellitus and its complications,
cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease,
Alzheimer's disease, dermatological disease, virus diseases, inflammatory disorders, or
diseases in which the liver is a target organ.
Narrative Review of Anomalous Origin of Coronary Arteries: Pathophysiology,
Management, and Treatment
Authors: Kanagala Sai Gautham , Gupta Vasu , Dunn Garrett V , Kaur Harmanjit , Zieneddine Farid , Jain Rohit , Garg Nikita
Published: June 2023

Coronary artery anomalies (CAA) are a diverse group of congenital anomalies and are
the second most common cause of sudden cardiac death in the young population after Hypertrophic
Cardiomyopathy (HCM). Symptoms range from chest pain, syncope, or sudden cardiac arrest to
completely asymptomatic. The prevalence of congenital coronary artery anomalies in the general
population is estimated to be between 1% and 2%. CAA often gets underdiagnosed due to the lack
of knowledge of the disease process. Approximately 5% of patients with acute myocardial infarction
do not have atherosclerotic coronary artery disease or luminal narrowing due to other causes.
Congenital coronary artery anomalies account for 50-60% of this 5% of patients. Most patients are
asymptomatic for most of their lives, and chest pain is the most common symptom in symptomatic
patients when referred for coronary angiography, typically when the diagnosis is typically made.
The malignant coronary artery is a rare presentation of a coronary anomaly when associated with
atherosclerotic coronary artery disease or valvular heart disease. Patients with symptoms of an abnormal
coronary artery origin will receive medical treatment/observation, exercise restriction, coronary
angioplasty with stent deployment, or surgical repair.
MDM2-mediated Inhibitory Effect of Arsenic Trioxide on Small Cell Lung Cancer
Cell Line by Degrading Mutant p53
Authors: Wang Yu-Sheng , Yin Ji-Zhong , Shi Xiao-Qian , Zhao Xue-Wei , Li Bing , Yang Meng-Hang
Published: June 2023

Introduction:

Small cell lung cancer (SCLC) is featured by a high TP53 mutant rate. Our previous research
found that arsenic trioxide (As2O3) could significantly inhibit the growth and metastasis of SCLC. Studies have shown
that the degradation of mutant p53 mediated by murine double minute 2 (MDM2) can be induced by As2O3, which
probably contributes to the inhibition of SCLC, but the detailed mechanism is still unclear. We aimed to testify that
As2O3 can inhibit the growth of SCLC cells by degrading mutant p53 protein via binding to MDM2.

Methods:

CCK-8 assay, cell cycle analysis, and western blot of apoptosis markers were used to evaluate the inhibitory
effect of As2O3 on NCI-H446 cells (containing mutant p53) and NCI-H1299 cells (p53 null). The effects of As2O3 on
p53 and its downstream proteins were identified by western blot using mut-p53-knockdown and overexpressed cell
models. MDM2-knockdown cell models were constructed, and western blot, co-IP of mut-p53, and ubiquitin were
carried out to explore the mediating effect of MDM2 in As2O3 induced mut-p53 degradation.

Results:

As2O3 inhibited proliferation and induced cell cycle arrest and apoptosis of SCLC cells in a dose- and timedependent
manner. After mut-p53 knockdown or overexpressed, the inhibitory effect of As2O3 was dampened or enhanced.
Additionally, As2O3-induced mut-p53 ubiquitination was significantly weakened after MDM2 knockdown.

Conclusion:

As2O3 could inhibit SCLC cells by inhibiting proliferation and inducing cell cycle arrest and apoptosis.
These inhibitory effects were achieved at least in part by upregulating MDM2, which, in turn, promotes ubiquitination
and degradation of mut-p53.
Phytosomal Drug Delivery System: A Detailed Study
Authors: Kamireddy Srikala , Sangeetha S. , Kosanam Sreya
Published: June 2023

Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies.
Van Dordtse Leerregels naar kanttekeningen bij de Statenvertaling. Een methodologische bijdrage
Authors: Schneider J. , Moehn W.H.Th.
Published: June 2023

This study seeks to answer the question of how the biblical references in the Canons of Dordt influenced the annotations in the margin of the ‘Statenvertaling’ (Authorized Version). Using the Microsoft Excel digital spreadsheet to analyse the results of existing research, the article illustrates how biblical references in the Canons of Dordt and the Heidelberg Catechism can be adequately compared, and then compares the marginal notes of the Deux-Aes Bible with the annotations of the Authorized Version. The conclusions shows that more than 25% of the relevant vocabulary in the annotations is found in the Canons of Dordt, but not in the quoted texts of the Authorized Version.
PRINCIPLES OF REGULATION AND PLACEMENT OF INDIVIDUAL VEHICLES
ON THE TERRITORY OF RESIDENTIAL DEVELOPMENT
Authors: Kolesnikov Alexander , Tsurik Tatiana , Kurakina Sofya
Published: June 2023

The analysis of approaches to the problem of permanent and temporary storage of personal transport in resi-dential buildings is given. The main reasons for the congestion of house territories with cars are shown. Using the example of the development of the city of Kursk, the actual number of parking spaces is investigated, which is com-pared with the calculated indicators made on the basis of regional regulatory documents. Examples of car storage in the existing buildings of two types are considered: the average number of storeys in the middle of the XX century and multi-storey buildings of the beginning of the XXI century. The results of the analysis are presented in the form of dia-grams illustrating the shortage of parking spaces in the territories of residential groups. The sequence of actions to ensure a sufficient number of parking spaces and reduce the load on the city's road network is given and justified: the construction of a minimum number of storage places for vehicles, taking into account its features, a ban on the com-missioning of residential and public buildings of any class without underground parking, subsidies for the purchase or rental of parking spaces for the population, the creation of a developed alternative to personal transport and com-pliance with parking requirements in designated areas. The use of architectural and planning solutions of parking lots for the existing urban development is justified. Using examples of the typical residential environment of Kursk makes it possible to apply the proposed methods for other cities.
Frequency of Prenatal Care Visits: Protocol to Develop a Core Outcome Set for Prenatal Care Schedules
Authors: Turrentine Mark , Nguyen Buu-Hac , Choby Beth , Kendig Susan , King Tekoa L , Kotelchuck Milton , Moore Simas Tiffany A , Srinivas Sindhu K , Zahn Christopher M , Peahl Alex Friedman
Published: June 2023

Background

Prenatal care, one of the most common preventive care services in the United States, endeavors to improve pregnancy outcomes through evidence-based screenings and interventions. Despite the prevalence of prenatal care and its importance to maternal and infant health, there are several debates about the best methods of prenatal care delivery, including the most appropriate schedule frequency and content of prenatal visits. Current US national guidelines recommend that low-risk individuals receive a standard schedule of 12 to 14 in-office visits, a care delivery model that has remained unchanged for almost a century.

Objective

In early 2020, to mitigate individuals’ exposure to the SARS-CoV-2 virus, prenatal care providers implemented new paradigms that altered the schedule frequency, interval, and modality (eg, telemedicine) of how prenatal care services were offered. In this paper, we describe the development of a core outcome set (COS) that can be used to evaluate the effect of the frequency of prenatal care schedules on maternal and infant outcomes.

Methods

We will systematically review the literature to identify previously reported outcomes important to individuals who receive prenatal care and the people who care for them. Stakeholders with expertise in prenatal care delivery (ie, patients or family members, health care providers, and public health professionals and policy makers) will rate the importance of identified outcomes in a web-based survey using a 3-round Delphi process. A digital consensus meeting will be held for a group of stakeholder representatives to discuss and vote on the outcomes to include in the final COS.

Results

The Delphi survey was initiated in July 2022 with invited 71 stakeholders. A digital consensus conference was conducted on October 11, 2022. Data are currently under analysis with plans to submit them in a subsequent manuscript.

Conclusions

More research about the optimal schedule frequency and modality for prenatal care delivery is needed. Standardizing outcomes that are measured and reported in evaluations of the recommended prenatal care schedules will assist evidence synthesis and results reported in systematic reviews and meta-analyses. Overall, this COS will expand the consistency and patient-centeredness of reported outcomes for various prenatal care delivery schedules and modalities, hopefully improving the overall efficacy of recommended care delivery for pregnant people and their families.

International Registered Report Identifier (IRRID)

DERR1-10.2196/43962
Perspectives of Rehabilitation Professionals on Implementing a Validated Home Telerehabilitation Intervention for Older Adults in Geriatric Rehabilitation: Multisite Focus Group Study
Authors: Pol Margriet , Qadeer Amarzish , van Hartingsveldt Margo , Choukou Mohamed-Amine
Published: June 2023

Background

Owing to demographic trends and increasing health care costs, quick discharge with geriatric rehabilitation at home is advised and recommended for older adults. Telerehabilitation has been identiﬁed as a promising tool to support rehabilitation at home. However, there is insufficient knowledge about how to implement a validated home telerehabilitation system in other contexts. One of the major challenges for rehabilitation professionals is transitioning to a blended work process in which human coaching is supplemented via digital care.

Objective

The study aimed to gain an in-depth understanding of the factors that influence the implementation of an evidence-based sensor monitoring intervention (SMI) for older adults by analyzing the perspectives of rehabilitation professionals working in 2 different health ecosystems and mapping SMI barriers and facilitators.

Methods

We adopted a qualitative study design to conduct 2 focus groups, 1 in person in the Netherlands during winter of 2017 and 1 on the web via Zoom (Zoom Video Communications; owing to the COVID-19 pandemic) in Canada during winter of 2022, to explore rehabilitation providers’ perspectives about implementing SMI. Qualitative data obtained were analyzed using thematic analysis. Participants were a group of rehabilitation professionals in the Netherlands who have previously worked with the SMI and a group of rehabilitation professionals in the province of Manitoba (Canada) who have not previously worked with the SMI but who were introduced to the intervention through a 30-minute web-based presentation before the focus group.

Results

The participants expressed different characteristics of the telerehabilitation intervention that contributed to making the intervention successful for at-home rehabilitation: focus on future participation goals, technology support provides the rehabilitation professionals with objective and additional insight into the daily functioning of the older adults at home, SMI can be used as a goal-setting tool, and SMI deepens their contact with older adults. The analysis showed facilitators of and barriers to the implementation of the telerehabilitation intervention. These included personal or client-related, therapist-related, and technology-related aspects.

Conclusions

Rehabilitation professionals believed that telerehabilitation could be suitable for monitoring and supporting older adults’ rehabilitation at home. To better guide the implementation of telerehabilitation in the daily practice of rehabilitation professionals, the following steps are needed: ensuring that technology is feasible for communities with limited digital health literacy and cognitive impairments, developing instruction tools and guidelines, and training and coaching of rehabilitation professionals.
Supporting Adolescents With HIV in South Africa Through an Adherence-Supporting App: Mixed Methods Beta-Testing Study
Authors: Mulawa Marta I , Mtukushe Bulelwa , Knippler Elizabeth T , Matiwane Mluleki , Al-Mujtaba Maryam , Muessig Kathryn E , Hoare Jacqueline , Hightow-Weidman Lisa B
Published: June 2023

Background

Novel smartphone app–delivered interventions have the potential to improve HIV treatment adherence among adolescents with HIV, although such interventions are limited. Our team has developed Masakhane Siphucule Impilo Yethu (MASI; Xhosa for “Let's empower each other and improve our health”), a smartphone app–delivered intervention to improve treatment adherence among adolescents with HIV in South Africa. MASI was adapted to the South African cultural context using the HealthMpowerment platform, an evidence-based digital health intervention developed for and with youth in the United States.

Objective

We conducted this beta-testing study to (1) explore the initial usability of MASI, (2) examine engagement and experiences using MASI features, and (3) inform refinements to the app and intervention implementation plan prior to a subsequent pilot randomized controlled trial (RCT).

Methods

This study was conducted from August 2021 to December 2021 in Cape Town, South Africa. Beta-testing participants received access to MASI for 3 weeks. A mixed methods approach was used, with brief questionnaires and semistructured in-depth interviews conducted prior to app installation and after 1 week to 2 weeks of app testing. Engagement with MASI was measured through analysis of back-end app paradata, and follow-up in-depth interview guides were tailored to each participant based on their app use.

Results

Participants in the beta-testing study (6 male participants, 6 female participants; ages 16-19 years) collectively spent 4.3 hours in MASI, averaging 21.4 minutes per participant over the 3-week period (range 1-51.8 minutes). Participants logged into MASI an average of 24.1 (range 10-75) times during the study period. The mean System Usability Scale score was 69.5 (SD 18), which is considered slightly above average for digital health apps. Thematic analysis of qualitative results revealed generally positive experiences across MASI features, although opportunities to refine the app and intervention delivery were identified.

Conclusions

Initial usability of MASI was high, and participants described having a generally positive experience across MASI features. Systematically analyzing paradata and using the interview findings to explore participant experiences allowed us to gain richer insights into patterns of participant engagement, enabling our team to further enhance MASI. The results from this study led to a few technological refinements to improve the user experience. Enhancements were also made to the intervention implementation plan in preparation for a pilot RCT. Lessons learned from the conduct of this beta-testing study may inform the development, implementation, and evaluation of similar app-delivered interventions in the future.
Expression Status of ABCC1, an ABC Transporter, Helps to Monitor Response to Chemotherapy in COAD Patients (Preprint)
Authors: Ejaz Samina
Published: June 2023

BACKGROUND

Worldwide increasing incident of colorectal adenocarcinoma (COAD) and development of resistance against chemotherapeutic drugs is a big challenge in recent era for researcher and health professional.

OBJECTIVE

This study was aimed to identify new biomarkers for early diagnosis, treatment and to overcome drug resistant in COAD patient. ABC transporter genes are key player in the development of resistance against chemotherapeutic drugs. Therefore, we initiate a study to explore the role of ABCC1 transporter by analyzing its mutatome, expression variations, promoter methylation level, clinical outcome, and drug sensitivity analysis in COAD patients

METHODS

We use cBioPortal and UALCAN to retrieve data regarding ABCC1 expression and its promoter methylation. KM plotter was used to retrieve data to study impact on survival of patient, and CCLE GDSC toolkit database was used for analysis of effect of ABCC1 overexpression on tumor’s response to various drugs.

RESULTS

Mutatome analysis show that in COAD patient ABCC1 was 2.2% mutated and most of frequent noted mutations were missense that are thought to be involved in up-regulation of ABCC1 transporter expression and may cause drug resistance. Data analysis from UALCAN showed that ABBC1 expression was high in COAD patients with various clinicopathological features than normal controls. Kaplan Meier survival analysis of ABCC1 show that overexpression decrease overall survival rate of the COAD patients.

CONCLUSIONS

Ultimately, the overexpression of ABCC1 was found decreasing the sensitivity of various important chemotherapeutic drugs in COAD patient via CCLE GDSC toolkit database analysis. By controlling overexpression of ABCC1, drug resistance can be overcome and effectiveness of various drugs can be increased in COAD patient
Quality of Online Sickle Cell Disease Resources for Healthcare Transition: A Scoping Review (Preprint)
Authors: Annesi Thomas , Steinway Caren , Oluwole Toyosi , Shilly Steffi , Szalda Dava , Myers Regina , Chen Jack , Jan Sophia
Published: June 2023

BACKGROUND

Adolescents and young adults with Sickle Cell Disease (SCD) transitioning from pediatric to adult healthcare face a high-risk period associated with increased use of acute healthcare services and mortality. While 59% of Americans report using the internet for health care information, the quality of online patient-facing resources regarding SCD transition has not been evaluated.

OBJECTIVE

This study aims to evaluate the quality and readability of online health information on Sickle Cell Disease, especially as it pertains to transition to adulthood. The study will also compare the readability and content scores of the websites from 2018 to those from 2021 to assess any change in quality over time.

METHODS

Keywords representing phrases adolescents may use while searching for information on the internet regarding SCD transition, including “Hydroxyurea” and “SCD Transition”, were identified. An online search using the keywords was conducted in July 2021 using Google, Yahoo, and Bing. The top 20 links from each search were collected. Duplicate websites, academic journals, and websites not related to SCD healthcare transition were excluded. Websites were categorized based on source: health departments/government body, hospitals/private clinics, professional organizations, and other. Websites were assessed using HONCode, Flesch Reading Ease (FRE), Flesch-Kincaid Grade Level (FGL), Ensuring Quality Information for Patients (EQIP), and a novel SCD content checklist (SCDCC). EQIP and SCDCC scores range from 0-100. Each website was reviewed by two research assistants and assessed for inter-rater reliability. Descriptive statistics were calculated.

RESULTS

Of 900 websites collected, 67 met inclusion criteria: 13 health departments, 7 hospitals or private clinics, 33 professional societies and 14 other. Fifteen websites (22.4%) had HONCode certification. Websites with HONCode had higher FRE and EQIP scores and lower FGL scores than those without HONCode, reflecting greater readability. Websites without HONCode had higher SCDCC scores, reflecting greater clinical content. Only 7 websites (10.4%) met the NIH recommendation of a 7th grade or lower reading level. Based on EQIP score, 6 websites (9.0%) were of high quality. The average SCDCC score was 20.6 ± 22.14; scores can range from 0-100. The interrater reliability in EQIP and SCDCC ratings was good (ICC: 0.718 and 0.897 respectively). No source of website scored significantly higher average EQIP, FRE, FGL, or SCDCC scores than the others.

CONCLUSIONS

Although seeking health care information online is very common, the overall quality of information about SCD transition on the internet is poor. Changes to current online healthcare information regarding SCD transition would benefit transitioning youth by providing expectations, knowledge, skills, and efficacy.
User-centred development of a portable training device using an active resistor for adaptive and passive movement control to tailor the intensity of rehabilitative walking exercise (Preprint)
Authors: Behrendt Frank , McCaskey Michael A. , Nielsen Einar , Graf Urs , Graf Eveline , Sommer Bettina , Hauser Romano , Kunz Andreas , Failer Diana , Failer Michael , Spicher Nicola , Schuster-Amft Corina
Published: June 2023

BACKGROUND

Patients with reduced fitness after acute illness often cannot adhere to the prescribed exercises regarding volume and intensity. Early aerobic exercise training, however, can enhance cardiopulmonary fitness and functional recovery. Nordic walking was suggested to be implemented in rehabilitation, but to be effective, a relatively high walking speed is required. The existing ToneFit belt induces a similar movement pattern to Nordic walking, but was designed for the use in the field of recreational sport providing a higher training intensity.

OBJECTIVE

The purpose of the described project was to develop a new version of the ToneFit belt aimed at improved cardiovascular functioning to meet the demands of neuro-orthopaedic rehabilitation.

METHODS

(a) In a first project phase, therapists evaluated the original version to determine clinical requirements for a modified version. Further, a prototype of was developed in a user-centred, iterative process with repeated consultations with the therapists. (b) It was biomechanically tested with a specific patient population for a potential impact on gait stability compared to walking without the device, and (c) evaluated for usability by 9 patients in a 3-4 week training programme.

RESULTS

(a) The evaluation of the original version of the fitness belt revealed a limited usability but necessary improvements could be defined. Several adjustments were made during the implementation phase, i.e., an adaptable intensity and a user interface for training recommendation and monitoring within a smartphone application. (b) The biomechanical analysis could show that walking with the device does not alter the gait pattern. (c) The usability of the prototype was rated as high by patients.

CONCLUSIONS

The project could show that this portable training device can be used well in the rehabilitation process. Final modifications regarding the software of the smartphone app and the design of the device should be made prior to a controlled study.
Investigating the Impact of Modern Educational Technology on Improving Human Resources with the Mediating Role of Information Literacy of Physical Education Teachers in the 2nd District of Karaj
Authors: Moharramzadeh Mehrdad , Moharramzadeh Nasser , Mahdavi Akbar
Published: June 2023

The aim of the research was the effect of modern educational technology on the improvement of human resources with the mediating role of information literacy of physical education teachers in the 2nd district of Karaj. The descriptive-analytical research method was field method. The current research community is 265 physical education teachers of Karaj District 2. The sample size of the present study was determined to be 265 people. The measurement tools included modern educational technology questionnaires (Yavuz, 2005), human resource improvement questionnaire (Volba & Jansen, 2010) and information literacy questionnaire (Siamak & Daverpanah, 2015). The content and form validity of the questionnaires were confirmed by the professors, and then Cronbach’s alpha reliability of the modern educational technology questionnaire was 0.70, Cronbach’s alpha reliability of the human resource improvement questionnaire was 0.81, and Cronbach’s alpha reliability of the information literacy questionnaire was 0.76. In order to analyze the data of the present research, structural equation modeling method was used. The entire process of analysis was done using spss19 and Amose23 software. The findings of the research showed that information literacy plays a mediating role in the impact of modern educational technology on the improvement of human resources. Therefore, it can be concluded that if human resources have sufficient information literacy, modern educational technology can create an environment that enriches the educational environment, skills, behavior, learning style and improvement of human resources.
Study of Small-Scale Capture Fisheries in West Sulawesi Waters “Case Study of Large Pelagic Fishing Rod In Mamuju Regency”
Authors: Roswati Roswati , Najamuddin Najamuddin , Nelwan Alfa Filep Petrus
Published: June 2023

Mamuju Regency, West Sulawesi Province, has the potential for pelagic fish, especially large pelagic fish, namely tuna, skipjack and cob, which are very prospective. The majority of fishermen in Mamuju Regency use fishing rods to catch large pelagic fish. Fishing rod fishermen with a large pelagic catch target are in Mamuju Regency, Simboro District, precisely in Sumare Village but currently it is known that there has been a decrease in the number of fishing rod fishermen in Mamuju Regency since the last 5 years experiencing a decrease in production. This study aims to determine the status of small-scale capture fisheries in a sustainability perspective according to ecological, technological, social and economic dimensions for small-scale fisheries in Mamuju Regency, and recommendations for sustainable capture fisheries. The study was conducted using qualitative methods using Rapfish analysis to determine the sustainability of fishing efforts. The results showed the highest dimensions in fish resources (70.13) and fishing technology (50.06) which means quite sustainable (good) while in the social dimension (38.47) and economic dimension (28.75) in the bad category which means there needs to be special attention in handling.
Guso (Eucheuma sp.) Ice Cream Enhanced with Blue ternate
Authors: D. Astillo Jessica , V. Avenido Margie , M. Bantilan Floramae , A. Laroda Rezel Jay
Published: June 2023

The main thrust of this study was to determine the profile of Guso (Eucheuma sp.) Ice Cream enhanced with Blue ternate in terms of ingredients and costing, tools and equipment, procedure, shelf life, nutritive value, sensory qualities and level of preferences in three different treatments in the aspect of appearance, taste, aroma, and texture. The study utilized experimental design with the aid of a descriptive questionnaire which determined the sensory preferences of the respondents towards the three treatments of the Ice cream in terms of appearance, taste, aroma, and texture. This study was conducted at Bohol Island State University in the six campuses with thirty (30) purposively selected participants who tasted and rated the Ice cream. To obtain the nutritive content samples were sent to the First Analytical Service and Technical Cooperative Laboratories for nutritional content and microbial analysis. After the data were retrieved, these were tabulated and interpreted using the Average Weighted Mean. The Friedman Test was used to obtain the difference in the participants’ sensory preferences for the three treatments. Findings revealed that the ingredients and tools in making the Guso (Eucheuma sp.) Ice Cream enhanced with Blue ternate were minimal, less expensive, and available in the local market. The nutritive content of the Guso (Eucheuma sp.) is Iron, Sodium, Calcium, Fats, Calories, Dietary fiber, Vitamin A, Vitamin C, and Vitamin D3 is within the range of recommended daily intake for Filipinos. Shelf life ranged from 2 to 3 months stored at the standard temperature of ice cream, which is 0°F (-18°C) or colder. All treatments of Guso (Eucheuma sp.) Ice Cream enhanced with Blue ternate was liked by the participants in all four attributes. Generally, the result of the study showed that there was a significant difference in the respondents’ preferences for Guso (Eucheuma sp.) Ice Cream enhanced with Blue ternate in terms of taste, and texture. Thus, the null hypothesis is rejected. However, data reveals that there is no significant difference in the respondents' preference for Guso (Eucheuma sp.) Ice Cream enhanced with Blue ternate in terms of appearance and aroma. Research findings showed that was a feasible nutritious Ice Cream safe for human consumption. Hence, a proposed technology guide is offered for the dissemination of the research output.
Curbing National Insecurity through Effective use of Language
Authors: Obadare Felicia Tomi
Published: June 2023

This study investigated curbing of national insecurity through effective use of language. The study assessed the present state of insecurity in Nigeria, language as a panacea to the insecurity ill that plague our nation, Nigeria and the role of language in ensuring peaceful co-existence in the nation. The study adopted a descriptive research design of survey type. The sample size of 100 respondents which included lecturers and students was drawn from the population of 345 members of Academic Staff Union of Universities (ASUU), Bamidele Olumilua University of Education, Science and Technology, Ikere chapter. The instrument for data collection was a self-structured questionnaire tagged “Language as a Panacea to Curbing Insecurity in Nigeria (LPCIN) Questionnaire”. The three research questions raised to guide the study were answered using descriptive analysis of simple frequency count, percentage, mean and standard deviation. The two (2) research hypotheses formulated for the study were tested using Chi-square (χ2) statistic of independent sample at 0.05 level of significance. Analysis of the study revealed that there was significant influence of language on the state of insecurity in Nigeria. It was also revealed that there was significant influence of appropriate use of language on the improved peaceful co-existence in Nigeria. The study concluded that the problem of national security is not that of the government alone but what every Nigerian should collaborate to ensure thorough effective and appropriate use of words of the accepted language communication. The study recommended that Nigerian government should create communication channels to effectively disseminate information, create awareness and give the people a sense of belonging and inclusion.
Optimal Intelligent Vehicle Control System for Emergency Vehicle Using Visible Light Communication VANET
Authors: Begum Shaeista , Patil Dr. Nagaraj B
Published: June 2023

Abstract: Traffic congestion is one of the significant problems in every metropolitan city. Traffic congestion occurs, when large numbers of vehicles are all together and are not able to move or move slowly, it is also known as a traffic jam. The main aim of the proposed OIVC-VLC VANET system is to improve the data transmission rate to control traffic in high density loads for emergency vehicles. Traffic congestion leads to wasting of time, road accidents, delays of trips, and reduces regional economic health and fuel consumption. Moreover, the most critical concern of traffic congestion is a delay of emergency vehicles like ambulance and police vehicles, and firefighting trucks leading to an increase the human death and loss their essential things. In addition, this paper focuses to reduce the traffic congestion and traveling time of emergency vehicles. To overcome traffic congestion issues, an Optimal Intelligent Vehicle Control System for the emergency vehicle by intelligent traffic clearance (OIVC-VLC-VANET) is proposed. Firstly an improved whale optimization (IWO) algorithm is submitted for grouping the vehicle nodes based on their behaviors. Secondly, the differential search algorithm is used to select the next forwarding node using multiple constraints received from vehicles. Thirdly, the dragonfly algorithm is submitted for avoiding extra time due to the control packets exchange process. The results show that the proposed OIVC-VLC-VANET system can perform very efficiently in terms of quality constraints than existing systems.
Smart Traffic Management System
Authors: Dwivedi Ashwani Dhar
Published: June 2023

Abstract: An efficient management system is imperative to address the frequent traffic congestion experienced at major intersections. This paper proposes the implementation of an intelligent traffic controller that utilizes real-time image processing. By employing various edge detection algorithms and object counting methods, the camera footage is analyzed to effectively manage the traffic flow. Previously, a matching method was employed, wherein cameras were installed alongside traffic lights to capture sequential image sequences. These images were then compared to a reference image depicting an empty road. However, in my paper, a filtering method is utilized instead. This method effectively filters out unwanted objects, focusing solely on vehicles, and accurately determines the number of cars present in each image.
Sustainable Water Management in Urban Architectural Design
Authors: Singh Vikram , Saxena Saurabh
Published: June 2023

Abstract: This article delves into the crucial role of sustainable water management in urban architectural design, highlighting its multi-faceted importance in ensuring water availability, preventing water-related disasters, promoting health and hygiene, preserving ecosystems, enhancing resilience to climate change, fostering social equity, and facilitating economic savings. The discussion is informed by a range of challenges in urban water management and offers a deep understanding of architecture's role in addressing these issues.
Multiple Deep Learning Approaches to Detect Pneumonia with Chest X-Ray
Authors: Ramdevputra Dhvani , Ramdevputra Dhruv , Shekhada Abhishek , Shah Ansh
Published: June 2023

Abstract: Pneumonia is one of the top 10 causes of death worldwide and the leading cause of death in young children. Chest Xray radiographs are often examined by highly qualified experts to look for pneumonia. Radiologists commonly disagree because of this laborious process. Computer-aided diagnostics systems have shown the ability to improve diagnosis accuracy. In this paper, we have given a computational technique for finding pneumonia regions using single-shot detectors, squeeze, and extinction deep convolution neural network (CNN) augmentations, and multi-task learning. One of the challenge's best results was obtained by a modified CNN model with the recommended procedure and got an accuracy of 96%, which was evaluated as part of the radiological society of North America's pneumonia detection challenge.
Evolutionary Algorithm in Game – A Systematic Review
Authors: Armanto Hendrawan , Rosyid Harits Ar , Muladi Muladi , Gunawan Gunawan
Published: June 2023

Research in the game field is increasingly numerous and challenging. The high interest in research on games is influenced by public awareness of the importance of games in developing ways of thinking, although it is undeniable that many people only pursue pleasure in playing games. In the past, not much games research has influenced into topics such as artificial intelligence, education, or other computer topics. But now games are having a tremendous impact on these topics. In fact, not infrequently games are used in various areas of life. Right now, artificial intelligence is an integral part of the game. If before, it was only used for creating an enemy. Right now artificial intelligence can affect various things, starting from assets, game difficulty levels, non-player characters (NPC), and even bots (AI agents) to run player characters. The complexity of artificial intelligence which is getting higher and higher requires a good optimization algorithm. The evolutionary algorithm is one of the optimization algorithms, even though it cannot find the best one, with the high speed it can find a good solution. Through this paper review, good conclusions are drawn regarding the use of evolutionary algorithms, representations made, fitness functions used, ways to prove a success, to what topics should be studied further.