bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer’s Disease in Nordic Populations
Authors: Motazedi Ehsan , Cheng Weiqiu , Thomassen Jesper Q. , Frei Oleksandr , Rongve Arvid , Athanasiu Lavinia , Bahrami Shahram , Shadrin Alexey , Ulstein Ingun , Stordal Eystein , Brækhus Anne , Saltvedt Ingvild , Sando Sigrid B. , O’Connell Kevin S. , Hindley Guy , van der Meer Dennis , Bergh Sverre , Nordestgaard Børge G. , Tybjærg-Hansen Anne , Bråthen Geir , Pihlstrøm Lasse , Djurovic Srdjan , Frikke-Schmidt Ruth , Fladby Tormod , Aarsland Dag , Selbæk Geir , Seibert Tyler M. , Dale Anders M. , Fan Chun C. , Andreassen Ole A.
Published: July 2022

Background:

Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer’s disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the model development population and part of the model genotypes are missing or need to be imputed.

Objective:

The aim of this study was to estimate age-dependent risk of late-onset AD using polygenic predictors in Nordic populations.

Methods:

We used Desikan PHS model, based on Cox proportional hazards assumption, to obtain age-dependent hazard scores for AD from individual genotypes in the Norwegian DemGene cohort ( n = 2,772). We assessed the risk discrimination and calibration of Desikan model and extended it by adding new genotype markers (the Desikan Nordic model). Finally, we evaluated both Desikan and Desikan Nordic models in two independent Danish cohorts: The Copenhagen City Heart Study (CCHS) cohort ( n = 7,643) and The Copenhagen General Population Study (CGPS) cohort ( n = 10,886).

Results:

We showed a robust prediction efficiency of Desikan model in stratifying AD risk groups in Nordic populations, even when some of the model SNPs were missing or imputed. We attempted to improve Desikan PHS model by adding new SNPs to it, but we still achieved similar risk discrimination and calibration with the extended model.

Conclusion:

PHS modeling has the potential to guide the timing of treatment initiation based on individual risk profiles and can help enrich clinical trials with people at high risk to AD in Nordic populations.
Correlation Between Plasma Oligomeric Amyloid-β and Performance on the Language Neutral Visual Cognitive Assessment Test in a Southeast Asian Population
Authors: Sandhu Gurveen Kaur , Zailan Fatin Zahra , Vipin Ashwati , Ann Soo See , Kumar Dilip , Ng Kok Pin , Kandiah Nagaendran
Published: July 2022

Oligomeric amyloid-β (OAβ), an upstream driver of Alzheimer’s disease (AD) neuropathology, correlates with poor cognitive performance and brain volume reduction. Its effect on cognitive performance measured by the language neutral Visual Cognitive Assessment Test (VCAT) remains to be evaluated. We studied the correlation of plasma OAβ with VCAT scores and grey matter volume (GMV) in a Southeast Asian cohort with mild cognitive impairment. Higher plasma OAβ significantly correlated with lower; cognitive scores (VCAT, Mini-Mental State Examination) and GMV/intracranial volume ratio. Such findings reveal the clinical utility of plasma OAβ as a promising biomarker and support validation through longitudinal studies.
Force and stiffness behavior of natural rubber based magnetorheological elastomer bushing
Authors: Abdul Hamid Mohamad Ihsan , Abd Fatah Abdul Yasser , Mazlan Saiful Amri , Ubaidillah Ubaidillah , Imaduddin Fitrian , Nordin Nur Azmah
Published: July 2022

This research introduces a magnetorheological elastomer (MRE) bushing that has the potential to be applied to vibration control for automotive applications. An annular shape of MRE bushing is designed and fabricated by natural rubber (NR) based MRE with homogenous distribution of carbonyl iron particles (CIPs). The component consists of five parts, which are the inner and outer pipes, MRE, coil bobbin that wound by an electromagnetic coil, top and bottom ring plates, and housing. Based on a conceptual design, the electromagnetic circuit is simulated using Finite Element Method Magnetics (FEMM) software for analyzing the distribution of magnetic flux. The fabricated MRE bushing is undergone a compression test and load adhesion test for the performance evaluation. The compression test is conducted by using the Universal Testing Machine (UTM) under various applied currents to obtain the force-displacement and stiffness behavior of the device. This study demonstrated that higher forces and stiffness are achieved compared to other MRE bushings. From here, at 5.5 mm of displacement, the ranges of forces are from 7.1 kN (off-state) to 8.5 kN (on-state at 2.5 A). Furthermore, the stiffness is increased by 19% from off-state to 2.5 A. Overall, the fabricated MRE bushing shows a significant response with the presence of the magnetic field from the simulation studies and experimental results. Thus, it has the potential for vibration control due to the ability to control rigidity.
Recent Microscopy Advances and the Applications to Huntington’s Disease Research
Authors: Babi Mouhanad , Neuman Kaitlyn , Peng Christina Y. , Maiuri Tamara , Suart Celeste E. , Truant Ray
Published: July 2022

Huntingtin is a 3144 amino acid protein defined as a scaffold protein with many intracellular locations that suggest functions in these compartments. Expansion of the CAG DNA tract in the huntingtin first exon is the cause of Huntington’s disease. An important tool in understanding the biological functions of huntingtin is molecular imaging at the single-cell level by microscopy and nanoscopy. The evolution of these technologies has accelerated since the Nobel Prize in Chemistry was awarded in 2014 for super-resolution nanoscopy. We are in a new era of light imaging at the single-cell level, not just for protein location, but also for protein conformation and biochemical function. Large-scale microscopy-based screening is also being accelerated by a coincident development of machine-based learning that offers a framework for truly unbiased data acquisition and analysis at very large scales. This review will summarize the newest technologies in light, electron, and atomic force microscopy in the context of unique challenges with huntingtin cell biology and biochemistry.
RETRACTED: A representation of bifinite domains by rough approximable concepts
Authors: Yao Lingjuan , Feng Zonghong , Wang Yong
Published: July 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Multiplicative consistency of linguistic preference relations with weakened hedges
Authors: Yao Xuan , Wang Hai , Xu Zeshui
Published: July 2022

Preference relations are often used to derive the priority of attributes and/or alternatives. Linguistic term with weakened hedges (LTWH) as a type of complex linguistic expressions can more straightforwardly describe the linguistic information provided by DMs when evaluating under uncertainties. The preference relations represented by LTWHs are an effective tool to model linguistic information. The concept and properties of additive consistency have been proposed before. This paper aims to study the multiplicative consistency of preference relations expressed by LWTHs. This paper constructs the principle of inspection for multiplicative consistency. Especially, the theories and algorithms for consistency checking and improving are proposed. We develop an automatic approach to improve a LWHPR that is not multiplicatively consistent. Finally, we demonstrate the practicality of the proposed method through a case study of evaluating the attributes in the prevention of haze pollution in China.
Retailer-driven incentive contracts for carbon emission reduction with carbon tax and yield uncertainty
Authors: Han Chao-Qun , Zhang Xiao-Hong , Ma Hong-Wei , Hu Zhi-Hua
Published: July 2022

Since the tax of carbon emission is popular and consumers are exhibiting low-carbon preference, a manufacturer may invest to adopt carbon emission reduction (CER) technologies to produce green products. In face of high cost of CER investment and random yield in low carbon production processes for the manufacturer, this paper explores the incentive role of the contracts of revenue-sharing (RS) and cost-sharing with subsidy (CSS) offered by a retailer in a low-carbon supply chain. Theoretical analysis and numerical experiments show that both RS and CSS can promote the manufacturer’s Carbon Emission Reduction (CER) efforts and improve the efficiency of the supply chain, and RS boosts these more than CSS. RS and CSS can also decrease firms’ profit losses due to yield uncertainty, and RS also decreases firms’ profit losses more than CSS. Moreover, to motivate manufacturer’s CER efforts, the government should levy the highest-possible carbon tax under RS, the medium-level carbon tax under CSS, and the lowest-possible carbon tax for the decentralized case, and levy the same carbon tax on the centralized case with that under RS.
Analysing key barriers to Industry 4.0 for sustainable supply chain management
Authors: Durmaz Nida , Budak Ayşenur
Published: July 2022

This study aims to define the adoption barriers to Industry 4.0 for sustainable supply chain and define their causalities and, dependencies, hierarchical levels of these barriers. Firstly, a framework for critical barriers to Industry 4.0 for sustainable supply chain management is created with literature review and experts for the first time. Then an integrated approach of Grey DEMATEL – ANP is proposed to analyze the adoption barriers to Industry 4.0 in sustainable supply chain management. The proposed method determines the cause-effect relationship among barriers, the strength of interactions, and the relative weights of critical barriers to Industry 4.0 in a sustainable supply chain. The results show that uncertainty about economic benefits, resistance to change, and lack of infrastructure and tools for Industry 4.0 in the Sustainable supply chain are crucial barriers to implementing Industry 4.0 technologies in SSC. This study can help decision-makers and managers define the barriers and provide the theoretical guideline to implement Industry 4.0 technologies across the sustainable supply chain successfully.
Taste Impairments in a Parkinson’s Disease Model Featuring Intranasal Rotenone Administration in Mice
Authors: Yin Dong Xu , Toyoda Hiroki , Nozaki Kazunori , Satoh Keitaro , Katagiri Ayano , Adachi Kazunori , Kato Takafumi , Sato Hajime
Published: July 2022

Background: Taste impairments are often accompanied by olfactory impairments in the early stage of Parkinson’s disease (PD). The development of animal models is required to elucidate the mechanisms underlying taste impairments in PD. Objective: This study was conducted to clarify whether the intranasal administration of rotenone causes taste impairments prior to motor deficits in mice. Methods: Rotenone was administrated to the right nose of mice once a day for 1 or 4 week(s). In the 1-week group, taste, olfactory, and motor function was assessed before and after a 1-week recovery period following the rotenone administration. Motor function was also continuously examined in the 4-weeks group from 0 to 5 weeks. After a behavioral test, the number of catecholamine neurons (CA-Nos) was counted in the regions responsible for taste, olfactory, and motor function. Results: taste and olfactory impairments were simultaneously observed without locomotor impairments in the 1-week group. The CA-Nos was significantly reduced in the olfactory bulb and nucleus of the solitary tract. In the 4-week group, locomotor impairments were observed from the third week, and a significant reduction in the CA-Nos was observed in the substantia nigra (SN) and ventral tegmental area (VTA) at the fifth week along with the weight loss. Conclusion: The intranasal administration of rotenone caused chemosensory and motor impairments in an administration time-period dependent manner. Since chemosensory impairments were expressed prior to the locomotor impairments followed by SN/VTA CA neurons loss, this rotenone administration model may contribute to the clarification of the prodromal symptoms of PD.
Rare Variant Analysis of PTRHD1 in Parkinson’s Disease in the Chinese Population
Authors: Li Chunyu , Ou Ruwei , Hou Yanbing , Chen Yongping , Wei Qianqian , Zhang Lingyu , Lin Junyu , Liu Kuncheng , Huang Jingxuan , Chen Xueping , Song Wei , Zhao Bi , Wu Ying , Shang Huifang
Published: July 2022

Homozygous missense variants in PTRHD1 have been identified to cause parkinsonism by segregation analysis in families. Further replication in the Parkinson’s disease (PD) population might provide additional insight. Here, we analyzed the rare variants in a Chinese PD cohort (Ncase = 1367, Ncontrol = 3298) with whole exome sequencing. We did not identify the variants described in previous studies, and no patient carried other homozygous or compound heterozygous variants of PTRHD1. Three rare variants were identified, but rare variants of PTRHD1 were not enriched in PD. Genetic screening suggested rare variants of PTRHD1 as disease cause were rare in PD in East Asians.
Validation of earlobe site as an alternative blood glucose testing approach
Authors: Owida Hamza Abu , Al-Nabulsi Jamal , Ma’touq Jumana , Al-Naami Bassam , Alnaimat Feras
Published: July 2022

BACKGROUND: Drawing blood from the fingertips for glucose testing is painful and likely to cause tissue damage over time. Earlobes are an alternative site for glucose measurement. OBJECTIVE: This work aims to validate the earlobe as an alternate test site for blood glucose testing by demonstrating valid and reliable statistically significant differences between the earlobes and standard reference sites. METHODS: Blood glucose concentrations from 50 volunteers were measured and statistically analysed from the reference sites (forearm and fingertip) and earlobe. The analysis included: 1) one-way analysis of variance (ANOVA), 2) regression analysis, 3) Bland Altman analysis, and 4) Clarke Error Grid analysis. RESULTS: The results indicated that there is no statistically significant difference between the three blood glucose-testing methods. For the forearm-earlobe and fingertip-earlobe, all measurements were grouped around the mean of 3.7 ± 1.96 SD and 2.96± 1.96 SD, respectively. Error grid analysis showed > 97% of all earlobe and references measurements fell in Zones A and B and were in the clinically acceptable level. CONCLUSIONS: The results have shown that the earlobe is a valid substitute for blood glucose measurements.
Multiscale asymmetry reveals changes in the maternal short-term heart rate dynamics of preeclamptic women during labor
Authors: Ceballos-Juárez Rosselin Gabriela , Pichardo-Carmona Elias Yojairi , Mendieta-Zerón Hugo , Echeverría Juan Carlos , Reyes-Lagos José Javier
Published: July 2022

BACKGROUND: It is known that acceleration and deceleration patterns in heart rate variability (HRV) are asymmetrically distributed in healthy subjects. Accordingly, novel approaches for assessing the asymmetrical properties of HRV, such as the multiscale asymmetry (MSA), have been applied in the perinatal field. OBJECTIVE: To study the asymmetry of accelerations and decelerations of maternal short-term cardiac dynamics of thirty-six normotensive and preeclamptic women during labor/nonlabor by MSA analysis. METHODS: The RR interval time series obtained from these participants were classified into four groups: normotensive (control) without labor C-NL, n= 10; control with labor C-L, n= 10; and two preeclamptic groups with absence or presence of labor P-NL, n= 6; and P-L, n= 10, respectively. Multiscale indices of heart rate asymmetry (HRA) such as Porta (P%), Guzik (G%) and Ehlers (E) were used to explore the changes of HRA in the normotensive and preeclamptic groups in the presence or absence of labor. RESULTS: The main result of this study shows that preeclamptic women manifest decreased magnitude of decelerations of heart rate dynamics compared to normotensive women indicated by G% and E. We speculate that a lower cardiac parasympathetic response may be manifested in preeclamptic women during labor/nonlabor compared to normotensive women. CONCLUSIONS: These observations represented a new insight into the autonomic cardiovascular regulation in preeclampsia, which could contribute to the perinatal field in the future.
Validation of the persian version of the COVID-19 prevention, recognition and home-management self-efficacy scale
Authors: Aslani Marzieh , Ebadi Abbas , Rostami Masoumeh , Repišti Selman , Hernández-Padilla José Manuel , Gheshlagh Reza Ghanei
Published: July 2022

ABSTRACT
INTRODUCTION. Adopting preventive behaviors and following the guidelines for controlling the COVID-19 epidemic depend on people’s self-efficacy in carrying out these behaviors and instructions. The aim of this study was to investigate the psychometric properties of the Persian version of the COVID-19 Self-Efficacy Scale (COVID-19 SES, Hernández-Padilla et al., 2020).
MATERIAL AND METHODS. This cross-sectional study was performed in a group of 400 people who were residents of the city of Asadabad in western Iran from December 2020 to January 2021. The participants were selected using a convenience sampling method. Face and content validity was assessed qualitatively based on feedback from the participants and experts, and the necessary changes were applied to the final version of the questionnaire. For construct validity, exploratory factor analysis (n=200) and confirmatory factor analysis (n=200) were performed. Internal consistency was expressed as Cronbach’s alpha coefficient. Relative stability was assessed using the intraclass correlation coefficient (ICC), and absolute stability was calculated through examination of standard error of measurement (SEM).
RESULTS. In exploratory factor analysis, three factors of prevention, symptom recognition, and homemanagement of COVID-19 were extracted that together explained 71.35% of the total variance. The internal consistency of the whole instrument was 0.955 and its three dimensions were 0.894, 0.916 and 0.955, respectively.
In addition, an ICC of 0.986 (95% CI: 0.975-0.993, p=0.001) was found. In the confirmatory factor analysis, comparative and parsimonious fit indices were excellent, and absolute fit indices were moderate.
CONCLUSIONS. The Persian version of the COVID-19 SES has good validity and reliability and can be used to measure self-efficacy in prevention, symptoms recognition, and home-management of COVID-19.
Pengaruh Budaya Organisasi dan Motivasi Kerja Terhadap Kepuasan Kerja Yang Berdampak pada Kinerja Karyawan pada PT Mutiara Sumber Rejeki di Tangerang
Authors: Muslimat Ade
Published: July 2022

Penelitian ini bertujuan untuk mengetahui pengaruh budaya organisasi dan motivasi kerja terhadap kepuasan kerja yang berdampak pada kinerja karyawan pada PT Mutiara Sumber Rejeki di Tangerang. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 100 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini Budaya organisasi berpengaruh signifikan terhadap kepuasan kerja sebesar 27,4%, uji hipotesis diperoleh signifikansi 0,000 < 0,05. Motivasi kerja berpengaruh signifikan terhadap kepuasan kerja sebesar 41,0%, uji  hipotesis diperoleh signifikansi 0,000 < 0,05. Budaya organisasi dan motivasi kerja secara simultan berpengaruh signifikan terhadap kepuasan kerja sebesar 51,7%, uji hipotesis diperoleh signifikansi 0,000 < 0,05.Kepuasan kerja berpengaruh signifikan terhadap kinerja karyawan sebesar 30,6%, uji  hipotesis diperoleh signifikansi 0,000 < 0,05.
FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP KUALITAS PEMERIKSAAN PAJAK DI INDONESIA
Authors: Daris Fiki Taufik , Winarningsih Srihadi , Devano Sony
Published: July 2022

The self assessment system require Directorate General of Taxation to conduct supervision of taxpayers effectively. One form if supervision is a tax audit which aims to assess the compliance of tax obligation. With limited resouces, DGT must cary out the good quality audits to be proper on target and have a broad impact on escalate tax compliance and revenue. The implementation and results of tax audit must be accountable and reliable in the eyes of stakeholders. This research is carried out with quantitative method using multiple regression analysis statistical test to determine how the effect of risk-based audit implementation, competence, professional skepticism, and the use of information technology on the quality of tax audits. The results of this study indicate that the variables of competence and utilization of information technology have an effect on the quality of tax audits, while the variables of riskbased audit implementation and professional skepticism have no effect toward the quality of tax audits. Simultaneously all the variables x affect the quality of tax audits
Kitâb-ı Güzîde’de Geçen İbadet Adları Üzerine
Authors: Türk Osman , Koç Fatma
Published: July 2022

Kitâb-ı Güzîde Türk dili tarihinde karışık dilli olarak anılan eserlerinden biridir. Karışık dilli eserler, hem Doğu Türkçesinin hem de Batı Türkçesinin dil özelliklerini taşıdığı için olga-bolga diliyle yazılan eserler olarak da adlandırılır. Kitâb-ı Güzîde Eski Anadolu Türkçesi ile yazılmış dinî içerikli kitaplardan biridir. Ebû Nasr bin Tahir bin Muhammed es-Serahsî tarafından olga-bolga diliyle kaleme alınmıştır. Türk dili tarihi açısından karışık dilli olarak ele anılan eser, ses ve şekil bilgisi açısından birçok araştırmalara tabii tutulmuştur. Olga-bolga dili, hem Doğu Türkçesinin hem de Batı Türkçesinin dil özelliklerini temsil eden bir dildir. Karışık dilli olarak adlandırılan eserler bu dil ile verilmiştir. Eserin yazarı hakkında yeterince bilgi bulunmamaktadır. Kitâb-ı Güzîde 14. Yüzyılda Anadolu Türkçesine aktarılmıştır. Kitâb-ı Güzîde bilim dünyasında Güzîde, Güzîde Kitabı, Kitab-ı Güzîde ve Akâid-i İslam şeklinde farklı isimlendirmelerle anılmaktadır. Dinî bilgilere ve öğütlere çokça yer verildiği için Arapça ve Farsça sözcüklere rastlamak mümkündür. Eser hem Doğu Türkçesinin hem de Batı Türkçesinin dil özelliklerini taşıdığı için karışık dilli eserler içerisinde değerlendirilmektedir. Eserin farklı adlarla tanınan nüshaları bulunmaktadır. Çalışma oluşturulurken Serhat Küçük’ün “Kitâb-ı Güzîde Akâidü’l-İslâm” adlı eseri esas alınmıştır. Eser içerisindeki ibadet adları tarama yöntemiyle tespit edilmiştir. Belirlenen sözcüklerle ilgili açıklamalara yer verilmiş ve sözcüklerin metin içerisinde geçtiği yerlere dair örnek cümleler metin numaraları ile verilmiştir. Çalışma metne dayalı olduğu için bir inceleme niteliği taşımakta olup ulaşılan veriler sonucunda değerlendirmeler yapılmıştır.
Identification of Effective Factors in Recurrence of Schizophrenia Spectrum Disorder Using Poisson Regression Model
Authors:   Department of Psychiatry, Faculty of Medical, Development Center Clinical Research, Imam Khomeini, Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran, Davarinejad Omran , Mohammadi Majd Tahereh ,   Department of Biostatistics, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran, Abbasi Masoumeh ,   Department of Health Information Technology, Faculty of Paramedical, Kermanshah University of Medical Sciences, Kermanshah, Iran, Eskandari Soudabeh ,   Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Published: July 2022

Background and Objectives: Schizophrenia is one of the most severe psychiatric disorders that has a recurrent nature. Frequent relapses have destructive impacts on patient’s thoughts, behaviors and relationships. These can lead to disruption of personal and social performance of patient. The aim of this study was to identify risk factors for increasing the number of relapses. Methods: In this retrospective cohort study, data from medical records of individuals with SSD who were admitted at least once to Farabi Hospital between 2015 and 2019 years extracted. To determine factors related to recurrence of Schizophrenia, Univariate and multivariate analysis and multivariate Poisson Regression were performed respectively. Analysis was done using STATA 14.1. Results: Based on extracted data from 401 medical records, 255 (63.6%) were males and 146 (36.4%) were females. A total of 1105 relapse were observed in males with 683 cases, and females with 422 cases. 65 patient experienced relapse from 5 to 11 times. Among considered variables, Employment status (RR=0.85, P-value=0.043), age (RR=0.99, P-value=0.03), Mode of Onset (RR=0.78, P-value=0.027) and Medication Adherence (RR=1.67, P<0.001) were significant on increasing readmission. Conclusion: According to the results of this study, the young age of onset of schizophrenia, the gradual onset of the disorder, unemployment and drug non-compliance had a significant effect on increasing the risk of recurrence in patients with schizophrenia. considering above risk factors, it seems necessary to perform preventive and therapeutic measures to reduce the risk of relapses. Patients with non-adherence can be under education and counseling.
Evaluation of Performance Indicators of Qazvin Educational and Medical Centers before and after the Implementation of the Health System Transformation Plan: Interrupted Time Series Analysis
Authors:   Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran, Ghasemzadeh Bahman , Shahsavari Saeed ,   Faculty of Health, Qazvin University of Medical Sciences, Qazvin, Iran, Maleki Aisa ,   Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran, Kalhor Rohollah ,   Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
Published: July 2022

Background and Objectives: The present study was conducted to investigate the status of performance indicators in hospitals affiliated to Qazvin University of Medical Sciences before and after the implementation of the transformation plan. Methods: This descriptive-analytical study was performed longitudinally based on hospital data. The data collection tool was a checklist including general characteristics of hospitals and performance indicators. Data analysis was performed using Interrupted time series analysis (ITS) and Statistical software for data science (STATA) v.15. Chow test was used to determine the structural fractures in the studied time series. Results: Hospitals’ performance indicators were examined. In the first month after the intervention, bed rotation increased significantly by 1.148 (P<0.005). The trend of bed rotation after the intervention increased by 0.060 per month (P=0.032). In the first month after the intervention, the decrease or increase in the length of stay in different hospitals was not significant (P>0.005). The length of stay after the intervention increased by 0.170 per month. In the first month after the intervention, the decrease in bed occupancy percentage was 41% (P=0.005) which is significant. The trend of bed occupancy percentage after the intervention was more than 2% per month (P<0.005). Conclusion: The transformation plan in the period before and after implementation in all studied hospitals has positive effects and has made changes in most performance indicators. This plan is especially beneficial for people who have fallen ill due to a lack of financial resources and have not been able to seek treatment.
ТЕРИТОРІАЛЬНІ ГРОМАДИ ЯК ПРОДУКТИВНА СИЛА РЕГІОНУ
Authors: Дороніна Майя Степанівна , Михайленко Дар’я Геннадіївна
Published: July 2022

The current stage of restoration of Ukrainian society requires in-depth study and improvement of theories and concepts of economics. Effective deployment of the country's productive forces and balanced development of its regions is an important condition for ensuring sustainable development of the national economy as a whole. A special direction of economic science has already been singled out in Ukraine: 08.00.05 development of productive forces and regional economy. Many recommendations have already been provided in relevant studies, but there are still many opportunities to make this more effective. The purpose of the study is to analyze and develop practical recommendations for the use of local communities as a productive force of the regions to ensure sustainable development of the national economy as a whole. The methodological basis of the study were legislative and regulatory acts, modern scientific and applied research of territorial communities. In order to substantiate proposals for the enrichment of productive forces by such a complex entity as a united territorial community, the article uses dialectical methods, the results of research on various disciplines of the humanities, methods and principles of scientific knowledge. The main hypothesis of the study was the assumption of the possibility of organizing viable territorial communities and using their combined potential to restore the positive dynamics of the economy in the postwar period. Presenting main material. The relationship between the role of economic and social capital in productive activity has changed in favor of social, which led to the definition of enterprise as an organization - a kind of social system, uniting people who jointly pursue a common goal and act on certain principles and rules. Important factors in the socio-economic development of society as a whole include the ability not only of scientists but also of individual businesses to generate and effectively use new knowledge about the nature of complex phenomena. The use of this knowledge provides organizations with an increase in intellectual capital, creates guarantees of high competitiveness. The originality and practical significance of the study is due to the analysis of the structural components of cluster formations, taking into account regional characteristics. Conclusions and prospects for further research. Important factors in the socio-economic development of society as a whole include the ability not only of scientists but also of individual businesses to generate and effectively use new knowledge about the nature of complex phenomena. Analysis and development of practical recommendations for the use of territorial communities as a productive force of the regions create the basis for determining the current reserves for the restoration of society in the postwar period. Under the new economic conditions, the requirements for the coordination of economic efficiency and social justice, professional mobility of the employee are growing.
Pengaruh Kompetensi dan Lingkungan Kerja Terhadap Kinerja dengan Motivasi Kerja sebagai Variabel Intervening
Authors: Lianasari Meta , Ahmadi Slamet
Published: July 2022

Penelitian ini bertujuan untuk menganalisis pengaruh kompetensi dan lingkungan kerja terhadap kinerja karyawan melalui motivasi kerja sebagai variabel intervening pada Pegawai Dinas Pariwisata dan Ekonomi Kreatif Provinsi DKI Jakarta. Teknik pengambilan sampel dalam penelitian ini menggunakan Teknik Slovin dari populasi sebanyak 153 orang dan didapat sampel sebanyak 111 orang. Pengumpulan data melalui kuesioner atau angket. Teknik analisis yang digunakan adalah analisis regresi, uji asumsi klasik dan analisis jalur (path analysis). Pengolahan data dalam penelitian ini menggunakan alat bantu SPSS Statistic 24. Berdasarkan hasil uji t-test menunjukkan bahwa variabel kompetensi berpengaruh positif terhadap motivasi kerja, lingkungan kerja berpengaruh negatif terhadap motivasi kerja, kompetensi berpengaruh positif terhadap kinerja pegawai, lingkungan kerja berpengaruh positif terhadap kinerja pegawai, motivasi kerja tidak berpengaruh terhadap kinerja pegawai. Hasil analisis jalur menunjukkan bahwa motivasi kerja tidak dapat memediasi variabel kompetensi dan kinerja karyawan, dan juga motivasi kerja tidak dapat memediasi variabel lingkungan kerja dan kinerja pegawai.
The Effect of Lifestyle Modification on Lipid Profile and Body Weight in Obese Subject
Authors: Ginting Sugama Trisna , Nasution Melati Silvanni
Published: July 2022

Background. The lifestyle modification (LSM) programs program addresses diet, exercise, stress management, and nutritional depletion using cognitive-behavioral approaches to improve the causes of chronic disease. The purpose of the study is to evaluate the effect before and after three months of LSM on lipid profile and body weight parameters of obese subjects
Method. The participants of age 25-50 years recruited through personal contact consisted of 20 obese subjects who appeared to engage in diet and regular exercise (get at least 150 minutes of exercise a week). The types of physical exercise aerobic (walking, swimming, jogging) were included in the study. The anthropometric measurements and blood sample was taken before and after three months of LSM. Height (m) is measured using a wall-mounted height bar and body weight (kg) is measured using a scale and its value is used in BMI calculations. The serum of profile lipid was determined by enzymatic colorimetric method and sd-LDL examination was performed indirectly in which the ratio of LDL /Apolipoprotein B.                                                    
Result. After 3 months of LSM, there was a significant decrease in serum LDL, ApoB, BMI, WC, and FPG (p < 0.05) in the obese subject. However, no significant difference was observed in TG, HDL, sd-LDL, PPG, and HbA1C (p>0.05).                       
Conclusion. Lifestyle modification of obese subjects for three months can decrease parameters of body weight and profiles lipids, which means it can prevent cardiovascular diseases.
- Bioentrepreunership for orphanages by making kokedama and capillary system plant cultivation
Authors: Hasanah Yaya
Published: July 2022

Bumi Nusantara Medan Orphanage is an orphanage located in Medan Sunggal District, Medan City. The location of the orphanage is quite close to the location of shops, schools and residential areas, so it is very strategic to be developed into a place of business considering that access to markets and buyers is very close. The purpose of this community service is to increase the empowerment of the orphanage community through urban farming-based bioentrepreneurship by making kokedama and capillary system plant cultivation, so that it becomes a business opportunity that can improve the welfare of the orphanage. The implementation method that will be carried out to solve this problem is through introduction, training and manufacture of kokedama and capillary system plant cultivation accompanied by direct practice and mentoring, and business management training. The results of the service that have been achieved are training and assistance in making kokedama and capillary system cultivation, training and hands-on practice on how to make kokedama, training and direct practice, namely training and mentoring in making kokedama and capillary system cultivation.
Empowerment of Fish Cultivation Supporting Integrated Agriculture in Youth Group, Langsat Permai Village, Bungaraya District, Siak Regency
Authors: Dini Isna Rahma , Hapsoh  , Sukendi  , Wawan
Published: July 2022

The construction of canal blocking on canals around community agricultural land in Langsat Permai Village through science and technology activities for Mitra Village in 2017-2019 has provided an increase in agricultural yields for both food crops and horticulture. Furthermore, the construction of canal blocking also has an impact on the use of canals for fish farming. Therefore, the purpose of this service activity is to provide assistance in the cultivation of catfish cages and the manufacture of fish feed based on agricultural raw materials and agricultural waste in karang taruna. The success of catfish growth is strongly influenced by the type and amount of feed given. The more feed that is given, the faster the fish will grow but the higher the production costs. Therefore, alternative feeds are needed to reduce the use of fish pellets by making feed made from agricultural raw materials and agricultural waste. Farmer is carried out both in fish cultivation and in the manufacture of fish feed by agricultural raw materials and agricultural waste. Based on the results, all members of karang taruna have understood about catfish farming activities in cages and making fish feed based on agricultural raw materials and agricultural waste. This shows that integrated agriculture has been formed in Langsat Permai Village.
WORKSHOP ON MAKING DOUGHNUT WITH THE ADDITION OF VEGETABLES AND FRUITS EXTRACT TO KASIH SAYANG PAUD STUDENT’S MOTHERS
Authors: Hairuddin Abduh
Published: July 2022

The prevalence of deficiency of vegetables and fruit consumption in Indonesia among children < 10 years is 93.6%. Donuts are snacks that also have some good nutritional content. The purpose of this community dedication is to increase the knowledge of parents, especially mothers of students in PAUD, about the benefits of vegetables and fruit. Improve skills in making donuts with a combination of vegetables and fruits juices to increase vegetables and fruits intake in preschool age children. The service was carried out at Kasih Sayang PAUD, the form of activity was counseling for 45 minutes and continued with training on making donuts with the addition of juice (green spinach, carrots, dragon fruit and chopped red spinach). The results of the training activities showed an increase in participants' knowledge from an average of 6.2 points before training to 8.27 points after training. Participants are also proficient in making donuts with the addition of vegetable and fruit juices.
АНАЛІТИКА СУЧАСНОГО СТАНУ ДОБРОБУТУ НАСЕЛЕННЯ УКРАЇНИ
Authors: Вдовин Мар’яна , Зомчак Лариса , Міщук Тетяна
Published: July 2022

Стаття присвячена проблемам оцінювання та аналізу добробуту населення. У статті описано чинники, які впливають на добробут населення країни, а також подано систему показників, які є ідентифікатором добробуту населення. Детально розглянуто показники економічного зростання, зокрема візуалізовано номінальний та реальний валовий внутрішній продукт на одну особу в динаміці. Здійснено аналіз динаміки чисельності населення та його зайнятості і доходів в Україні у 2011–2021 роках, оцінено структуру та динаміку доходів та витрат населення, простежено динаміку середньомісячної номінальної та реальної заробітної плати штатних працівників України у 2011–2021 роках, а також проаналізовано динаміку показника оплати праці, пенсійного забезпечення та їх співвідношення за 2011-2021 рр. Крім цього, досліджено джерела фінансування витрат у сфері освіти та охорони здоров’я.
ДЕТЕРМІНАНТИ НАЦІОНАЛЬНОГО ЗАСТОСУВАННЯ НОВОЇ КОМП’ЮТЕРИЗОВАНОЇ ТРАНЗИТНОЇ СИСТЕМИ (NCTS)
Authors: Капітанець Світлана , Брендак Аліна
Published: July 2022

У статті розглянуто питання повномасштабного застосування національної електронної транзитної системи в Україні. Вказано на важливість приєднання нашої держави до Конвенції про процедуру спільного транзиту задля підвищення вітчизняного транзитного потенціалу та ефективної протидії спробам митного шахрайства під час переміщення товарів через митний кордон України. Досліджено хронологію національного застосування NCTS. Встановлено та описано детермінанти – процедурні особливості та результативні показники, котрі характеризують кожен етап застосування NCTS. Констатовано, що Держмитслужбою продовжено роботу та взаємодію з представниками ЄС щодо реалізації тих заходів, які наближають Україну до приєднання в подальшому до Конвенції. Зроблено припущення, що продовження адаптації національного законодавства, включаючи оновлення таблиці апроксимації законодавства та підготовку необхідних змін до нормативно-правових актів, стане однією з детермінант, котрі визначатимуть готовність України приєднатися до Конвенції.
СУЧАСНІ ТЕНДЕНЦІЇ РОЗВИТКУ ГЛОБАЛЬНОГО РИНКУ ТРАНСПОРТНО-ЛОГІСТИЧНИХ ПОСЛУГ
Authors: Сташенко Юлія , Гавриловський Олександр
Published: July 2022

Стаття присвячена актуальним питанням розвитку глобального ринку транспортно-логістичних послуг які визначається цілою низкою обставин. Проаналізовано прискорення процесів взаємодії всіх галузей економіки, які провокують транспортний сектор на постійні поліпшення. Досліджено транспортний сектор, який є одним з основних факторів глобалізації як міжнародної торгівлі, так і транснаціональних компаній, оскільки розвиток міжнародних та внутрішніх ринків у всі часи супроводжувався вільним переміщенням товарів та ресурсів. Розглянуто суперечливі тенденції інфраструктурного сектору та залежність транспорту від галузей матеріальних благ. Окреслено резерви впливу на регіональний розподіл виробничих потужностей, які беруть участь у процесі відтворення і виступають у ролі одного з основних елементів системи економічних відносин.
Pengaruh Metode Ceramah Dan Simulasi Start Triage Terhadap Pengetahuan Relawan Non-Medis
Authors: Purwana Eka Rudy , Zulkifli Zulkifli
Published: July 2022

Latar Belakang : Triage sebagai pintu gerbang perawatan pasien memegang peranan penting dalam pengaturan darurat melalui pengelompokan dan memprioritaskan pasien. bencana dapat mengakibatkan berbagai dampak yang serius. Untuk mengurangi dampak yang terjadi triage sangat penting dilakukan terutama untuk mengurangi dampak korban jiwa. Untuk bisa melakukan trige seseorang harus memiliki pengetahuan yang dapat diberikan melalui berbagai cara salah satunya adalah metode ceramah dan simulasi.Tujuan :Mengetahui pengaruh metode ceramah dan simulasi terhadap pengetahuan relawan non medis tentang START TriageMetode : Desain penelitian yang digunakan adalah pra experimental one group pretest–posttest. Populasi pada penelitian ini adalah semua relawan non medis di Desa Langko.Sampel dalam penelitian ini 50. Pengambilan sampelmenggunakantotal samplingdengan menggunakan kuisioner dan ceklist, tekhnik analisis data menggunakan analisis Uji Wilcoxon Signed Rank Test.Hasil :Hasil penelitian didapatkan, metode ceramah dan simulasitentang START Triage data pengetahuan sebelum 84% kurang sesudah 52% cukup dan data nilai (pengetahuan : ρ = 0,000, dan
Pengaruh Participatory Learning Approach (PLA) terhadap Pengetahuan dan Kesadaran Ibu dalam Pencegahan Stunting
Authors: Kapadia Raju , Nurbani Nurbani , Agustina Mita
Published: July 2022

A mother in the family has an important in fulfilling family nutrition to prevent stunting. Various methods and counseling to mothers to increase knowledge have been widely given, but most are still traditional or one-way models. The learning approach that is currently being developed is a learning model that involves an active role or maximum participation so that the learning target is more involved. Participatory Learning Approach PLA) is a method that is believed not only to increase knowledge but also increase awareness about learning materials to a deeper extent. Through a combination of lectures, demonstrations, discussions and presentations, it is hoped that there will be an increase in knowledge and awareness of mothers will be better. This study aims to identify the influence of participatory learning approach techniques in increasing maternal awareness and knowledge in stunting prevention. The research was conducted using the Quasi Experimental method, with the Pre And Post Test With Control Group Design model. Data collection was carried out through a 3S (Sehari Sadar Stunting) learning program to 50 mothers divided into two groups. The intervention group was given a one-day learning program with a Participatory Learning Approach approach, namely a combination of lectures, demonstrations, discussions and presentations.While the control group was given a joint program but with a traditional learning model.  The two groups then conducted a pre and post test looking for differences in scores through the paired t test. The results of the study obtained by the implementation of PLA were able to increase maternal knowledge about stunting with the results of paired t tests in pre-post tests increased significantly p 0.001 (p > 0.005). This method is also able to increase maternal awareness in stunting prevention measures through pregnancy screening, exclusive breastfeeding, supplemental feeding and food processing varyingly. The conclusion of this study is that the implementation of the Participatory Learning Approach method is able to increase the understanding and awareness of mothers and mothers-to-be in stunting prevention measures. The implementation of methods of increasing maternal participation needs to be improved in the form of maternal empowerment actions in stunting prevention
Pengaruh Konsumsi Tuak Terhadap Kadar Asam Urat Pada Masyarakat Dewasa di Desa Jagaraga Timur
Authors: Juliantini Ni Komang , Fihiruddin Fihiruddin , Jiwantoro Yudha Anggit
Published: July 2022

Tuak is a type of alcoholic drink made from palm sugar. Excessive consumption of tuak continuously can increase the levels of uric acid in the body. Uric acid is the end product of purine metabolism. This study aimed to determine the effect of tuak consumption of uric acid levels in the adult community in East Jagaraga Village. This research is an analytical observation using a cross-sectional approach. The sampling technique was a simple random sampling of 48 people, namely 24 adults that consumed tuak and 24 adults who did not consume tuak. Data analysis in SPSS used an independent sample t-test. The average uric acid levels in 24 respondents that consumed and did not consume tuak were 7.46 mg/dl and 4.92 mg/dl, respectively. The results show that there is an effect of tuak consumption uric acid levels in the adult community in the East Jagaraga Village, this is shown in a probability value (p = 0.000) <0.05 then Ho is rejected and Ha is accepted. From these results, it can be concluded that the consumption of tuak in the long term affects increasing uric acid levels.
EXPLANATION THROUGH THE MEDIA OF CULTURAL FIGURE BAYAN (WETUTELU) ON KNOWLEDGE OF MOTHERS TO CHILDREN ABOUT BALANCED NUTRITION MESSAGES
Authors: Fine Suwidari , Chandradewi AASP , Abdi Lalu Khairul , Laraeni Yuli
Published: July 2022

Background: One of the efforts to overcome nutritional problems is to increase knowledge about nutrition through nutrition counseling. Learning can be influenced by education. People with higher education tend to have a broader understanding and an openness to accept new things. Meanwhile, someone with low education tends to have old thinking patterns and is less open to new things, including powerful areas in holding their customs. One way to influence the community's mindset in such conditions is to use a trusted communication facilitator who can be a role model for the community. So that in this study, the role of traditional leaders is used so that the community is more receptive to the material presented. Objective: To determine the effect of counseling through the media of Wetu Telu Bayan traditional leaders on the knowledge of mothers of children under five about the message of balanced nutrition. Methods: This research is a pre-experimental study that allows testing the changes after the intervention. The research design used is a one-group pre-test-post-test design. Result: An increase in knowledge scores in the form of differences in scores from pretest to post-test. Analysis using Wilcoxon regarding the effect of counseling on balanced nutrition messages by traditional leaders on the knowledge of mothers of children under five, the results were p = 0.00 or p <0.05, meaning that there was an effect. Conclusion: There is an effect of counseling through the media of Wetu Telu Bayan traditional leaders on the knowledge of mothers of children under five about the message of balanced nutrition.