bluuebunny/crossref_metadata_2025 huggingface dataset:
First Stage Seed-Cotton Cleaning System Particulate Emission Factors for Cotton Gins: Particle Size Distribution Characteristics
Authors: Whitelock Derek , Boyer Michael , Boykin Clif , Holt Gregory
Published: June 2024

This report is part of a project to characterize cotton gin emissions from the standpoint of total particulate stack sampling and particle size analyses. In 2006 and again in 2013, the United States (U.S.) Environmental Protection Agency (EPA) published a more stringent National Ambient Air Quality Standard for particulate matter with nominal diameter less than or equal to 2.5 µm (PM2.5). This created an urgent need to collect additional cotton gin emissions data to address current regulatory issues, because EPA AP-42 cotton gin PM2.5 emission factors were limited. In addition, current EPA AP-42 emission factor quality ratings for cotton gin PM10 (particulate matter with nominal diameter less than or equal to 10 µm) data are questionable, being extremely low. The objective of this study was to characterize particulate emissions for 1st stage seed-cotton cleaning systems from cotton gins across the cotton belt based on particle size distribution analysis of total particulate samples from EPA-approved stack sampling methods. Average measured PM2.5, PM6, and PM10 emission factors based on the mass and particle size analyses of EPA Method 17 total particulate filter and wash samples from seven gins (18 total test runs) were 0.0045 kg/227-kg bale (0.010 lb/500-lb bale), 0.042 kg/bale (0.092 lb/bale), and 0.072 kg/bale (0.159 lb/bale), respectively. The 1st stage seed-cotton cleaning system particle size distributions were characterized by an average mass median diameter of 10.7 µm (aerodynamic equivalent diameter). Based on system average emission factors, the ratio of PM2.5 to total particulate was 2.99%, PM6 to total particulate was 27.5%, and PM10 to total particulate was 47.5%.
Eficacia de la aplicación del régimen jurídico de las medidas cautelares constitucionales: Análisis a partir del caso de Jorge Glas
Authors: Corrales Andrea
Published: June 2024

El presente artículo expone la eficacia de la aplicación del régimen jurídico de las medidas cautelares constitucionales: análisis a partir del caso de Jorge Glas. Ecuador, al ser un estado constitucional, de derechos y justicia, establece varias garantías y métodos, alguno de ellos, a fin de garantizar; otros, evitar o cesar la vulneración de derechos, verbigracia, medidas cautelares. El artículo 87 de la Constitución establece que las medidas cautelares son mecanismos provisionales que pueden ser activados de manera autónoma y conjunta, con el objetivo de prevenir, impedir o evitar la transgresión de un derecho que aún no se encuentra vulnerado, sino que exista una probabilidad de sufrir un daño grave.  La investigación inicia con el estudio de la literatura especializada, doctrina y de las reglas jurisprudenciales para delimitar la finalidad, la naturaleza, los requisitos de aplicación y pertinencia, parámetros específicos de las medidas cautelares constitucionales. Se identificará los hechos, los argumentos de la motivación y la normativa aplicable, a través del análisis de la resolución, emitida por el Juez de la Unidad Penal del Cantón Santo Domingo, que concede la libertad al señor Jorge David Glas Espinel, ex vicepresidente del Ecuador, por medio de la aplicación de una medida cautelar.
NEW CORONAVIRUS INFECTION SARS-COV-2. EPIDEMIOLOGY, PATHOGENESIS. CLINICAL MANIFESTATIONS, ASSOCIATED WITH THE GASTROINTESTINAL TRACT
Authors: Ниязов Рустам Мурадович , Савченко Яна Вячеславовна
Published: June 2024

Впервые РНК вируса SARS-CoV-2 была выявлена 8 декабря 2019 года у пациента с пневмонией. 31 декабря 2019 года Всемирная организация здравоохранения (ВОЗ) была оповещена о нескольких случаях вирусной пневмонии, вызванной неизвестным патогеном. 7 января 2020 года информация о новом вирусе была подтверждена, а сам вирус был отнесен к коронавирусам. В январе 2020 года ВОЗ объявила вспышку, связанную с SARS-CoV-2, а 11 марта 2020 года охарактеризовала принявшее мировой масштаб распространение болезни как пандемию. COVID-19 широко известен как заболевание, вызывающее респираторную дисфункцию, однако оно также связано с массой внелегочных проявлений: нарушение свертываемости крови, дисфункция миокарда и аритмия, острый коронарный синдром, острая почечная недостаточность, желудочно-кишечные расстройства, гепатоцеллюлярные повреждения, гипергликемия и кетоз, неврологические заболевания, глазные симптомы и дерматологические осложнения. В данном обзоре затронута эпидемиология, патогенез новой коронавирусной инфекции, а также поражения желудочно-кишечного тракта вирусом SARS-CoV-2.

The RNA of the SARS-CoV-2 virus was first detected on December 8, 2019 in a patient with pneumonia. On December 31, 2019, the World Health Organization (WHO) was alerted to several cases of viral pneumonia caused by an unknown pathogen. On January 7, 2020, information about the new virus was confirmed, and the virus itself was classified as a coronavirus. In January 2020, WHO declared an outbreak associated with SARS-CoV-2, and on March 11, 2020, characterized the global spread of the disease as a pandemic. COVID-19 is widely known as a disease that causes respiratory dysfunction, however, it is also associated with a host of extrapulmonary manifestations: bleeding disorders, myocardial dysfunction and arrhythmia, acute  coronary syndrome, acute renal failure, gastrointestinal disorders, hepatocellular damage, hyperglycemia and ketosis, neurological diseases, ocular symptoms and dermatological complications. This review covers the epidemiology, pathogenesis of NCVI, as well as damage to the gastrointestinal  tract by the SARS-CoV-2 virus.
The combined arts therapies team: Sharing practice development in the National Health Service in England
Authors: Hackett Simon
Published: June 2024

The complex nature of many arts therapies interventions indicates a richness in practice development and the number of potential applications in the clinical, social and cultural sectors. There is greater opportunity to consider the overlap of shared models, skills, techniques and approaches in the arts therapies, and in a combined arts therapies team in the National Health Service (NHS) some early examples of interdisciplinary practice sharing have emerged. A number of practice-based examples are used to illustrate the work of a combined arts therapies team in the NHS in England. Combined practice developments are described, including shared therapeutic levels, shared observations, shared techniques and shared therapeutic work. It is hoped that these areas of shared development within a clinical context will lead to practice developments that support improved outcomes for clients.
A Guide to Evaluation for Arts Therapists and Arts and Health Practitioners (Giorgos Tsiris, Mercédès Pavlicevic & Camilla Farrant)
Authors: Derrington Philippa
Published: June 2024

This is a review of the book "A Guide to Evaluation for Arts Therapists and Arts and Health Practitioners" authored by Giorgos Tsiris, Mercédès Pavlicevic & Camilla Farrant.
Title: A Guide to Evaluation for Arts Therapists and Arts and Health Practitioners | Authors: Giorgos Tsiris, Mercédès Pavlicevic & Camilla  Farrant | Year: 2014 | Publisher: Jessica Kingsley | Pages: 176 | ISBN: 978-1-84905-418-8
Case managers within general practices in 11 Western countries: repeat cross-sectional studies
Authors: Berret Romane , Senn Nicolas , Maisonneuve Hubert , Cohidon Christine
Published: June 2024

BACKGROUND: In the context of an ageing population and increasing health needs, primary care reform is needed and several new models have emerged, including the introduction of case managers in general practitioner practices.
AIM: To describe the frequency of case managers in general practices in eleven Western countries between 2012 and 2019 and to investigate the characteristics of general practitioners and their practices associated with case manager frequency.
METHODS: A secondary analysis of the Commonwealth Fund International Health Policy Surveys of Primary Care Physicians, which were international cross-sectional studies conducted in 2012, 2015 and 2019. Random samples of general practitioners were selected in 11 Western countries (2012: n = 9776; 2015: n = 12,049; 2019: n = 13,200). The use of case managers in general practitioner practices was determined with the question “Does your practice use personnel, such as nurses or case managers, to monitor and manage care for patients with chronic conditions that need regular follow-up care?”, with possible answers “Yes, within the practice”, “Yes, outside the practice”, “Yes, both within and outside the practice” or “No”. Other variables characterising general practitioners and their practices were considered. Mixed-effects logistic regression was performed.
RESULTS: The frequency of case managers within general practitioner practices varied greatly by country, with an overall trend towards an increase from 2012 to 2019. In the multivariate analysis, more case managers were found in practices located in small towns (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.2–1.7) and in rural areas (OR 1.9; 95% CI 1.5–2.4) compared to cities. The frequency of case managers was higher in larger practices, as shown in comparisons of practices in the second, third and fourth quartile of full-time equivalent employee counts compared to those in the first quartile (Q2: OR 1.7, 95% CI 1.4–1.9; Q3: OR 2.1, 95% CI 1.6–2.9; Q4: OR 3.8, 95% CI 3.0–4.9). There was no significant difference in frequency with respect to the age and sex of the general practitioners.
CONCLUSION: The use of case managers in general practitioner practices is a promising approach, but its practice varies greatly. This practice has been developing in Western countries and is tending to increase. The implementation of case managers seems to be associated with certain characteristics linked to general practitioner practices (practice location, practice size), whereas it does not seem to depend on the personal characteristics of general practitioners, such as age or sex.
Short-Term Rentals In Multi-Owned Buildings
Authors: Josipović Tatjana
Published: June 2024

Short-term rentals in multi-owned buildings – interplay between public and private restrictions on the provision of short-term accommodation services The text discusses the rise of cross-border short-term rentals facilitated by online platforms and highlights concerns such as nuisance and housing availability. Legal questions arising from the collaborative economy are explored, emphasizing effective communication between authorities and platforms. The need for a comprehensive analysis of public and private law aspects in regulating short-term rentals at both EU and national levels is stressed. The legal framework governing short-term rental services is examined, focusing on the Services Directive as the primary EU legislation. The challenges of justifying national restrictions on short-term rentals, considering fundamental rights perspectives, are discussed. Legal complexities in multi-owned buildings, including the importance of owners' agreements, are explored, with considerations for national regulations and potential conflicts with EU law. The author highlights intricate legal relations in short-term rentals involving stakeholders and anticipates the need for national legislators to specify legal relations due to the increasing use of online platforms. The text emphasizes the importance of a just balance between renters and other flat owners. It suggests the necessity of substantial and detailed EU regulations for cross-border provision of short-term accommodation services, potentially influencing changes in national condominium laws and contributing to positive developments in the EU digital market.
Zur Entstehung des Staates
Authors: Schröder Peter
Published: June 2024

In early modern Europe, a new concept of the state emerged, initially consisting of the simple but ambitious claim to guarantee peace and security. The authors in this volume not only helped to shape the political discourse of their time, but their writings also provided a reservoir of ideas, terms and concepts from which we still draw today. These thinkers competed over the best way forward, over what could and should be drawn from this reservoir for the development of politics and the state. The main aim of this volume is to provide a better understanding of this debate.
Klopstock!
Authors: Kauffmann Kai
Published: June 2024

Frisch und mit sicherer Hand zeichnet Kai Kauffmann Leben und Werk des Meisters des Sprachexperiments in dieser lang erwarteten Biographie nach Friedrich Gottlieb Klopstock war der berühmteste deutsche Dichter des 18. Jahrhunderts vor Goethe. Zu seinem 300. Geburtstag erscheint nun eine neue Biographie, die zum ersten Mal auch das gesamte Werk von den ersten Gesängen des »Messias« bis hin zu den späten Oden über die Französische Revolution würdigt. Sie beschreibt die Stationen seiner Lebensreise als Orte der Sozial- und Kulturgeschichte: Quedlinburg, Schulpforta, Jena, Leipzig, Zürich, Kopenhagen und Hamburg. Die unglückliche Liebe zu einer Kusine, der »Fanny« der frühen Oden, und die glückliche Ehe mit Meta Klopstock werden ebenso geschildert wie die Freundschaften mit zahlreichen Dichtern und Künstlern der Zeit, darunter J. J. Bodmer, G. A. Bürger, Ch. F. Gellert, J. W. L. Gleim, J. W. von Goethe, F. von Hagedorn, J. G. von Herder, A. L. Karsch, A. Kauffmann, J. C. Lavater, G. E. Lessing, M. Mendelssohn, J. H. Voß und Ch. M. Wieland. In den Kapiteln zu seinen Schriften werden auch die kulturpolitischen Projekte, etwa eine tiefgreifende Reform der deutschen Rechtschreibung, im geschichtlichen Kontext dargestellt und verständlich erklärt. So entsteht das Bild eines faszinierenden Menschen und radikalen Dichters, der bis zu seinem Lebensende mit neuen Themen und Formen experimentierte. Kai Kauffmann führt mit Leichtigkeit durch das lange und abwechslungsreiche Dichterleben.
Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Unraveling Molecular Pathways, Immunometabolic Processes, and Their Significance in Immunotherapy for Hepatocellular Carcinoma (HCC)
Authors: Chu Chia-Sheng , Wu Li-Ling
Published: June 2024

Hepatocellular carcinoma (HCC) is a major global health concern, and understanding the complex interplay of immune cells within the tumor microenvironment is crucial. This review explores the roles of myeloid-derived suppressor cells (MDSCs) and macrophages in HCC, focusing on their molecular pathways, immunometabolic processes, and implications for immunotherapy. We begin by elucidating the origin, expansion, and immunosuppressive mechanisms of MDSCs, emphasizing the importance of molecular pathways and immunometabolism in regulating their functions. In parallel, we delve into the dual nature of tumor-associated macrophages (TAMs) and discuss the molecular and metabolic cues governing their plasticity. Tumor metabolism is a central theme, with a comprehensive overview of altered metabolic processes in cancer cells and their impact on immune cells in the tumor microenvironment. We examine the metabolic crosstalk between tumor cells, MDSCs, and macrophages, shedding light on how tumor metabolism contributes to immune evasion. Furthermore, we discuss the challenges and limitations faced in the clinical application of immunotherapy in HCC. In conclusion, this review highlights the intricate web of molecular pathways and immunometabolic processes shaping the functions of MDSCs and macrophages in HCC. Understanding these dynamics is essential for the innovative immunotherapeutic interventions in HCC, improving outcomes of this devastating disease.
First Generation Iranian Refugees and their Acculturation in the United States
Authors: Hormozi Tania
Published: June 2024

The purpose of this chapter is to identify the causes that Iranians migrate out of their country, as well as the struggles and strengths of acculturation for first-generation Iranian refugees in the United States (U.S.). Many individuals and clinicians are unaware of how to work with certain immigrant and refugee populations, and this review will inform those individuals and clinicians of ways to work with, treat, and help these families upon arrival and acculturation into the U.S. Ten participants were interviewed to share experiences of their acculturation process in the U.S. Themes were found from the interviews to include language barriers, isolation from families, and lifestyle changes. This chapter will include additional research about why Iranian refugees fled Iran, historical information about the Islamic Republic and its regulations on its people, as well as the acculturation process for Iranian refugees in the United States.
Role of Amikacin in the Management of Ventilator-Associated Pneumonia
Authors: Moeed Abdul , Bilal Zoha , Batool Fizzah , Batool Zaidi Asma , Arsalan Jamil Muhammad , Surani Salim
Published: June 2024

Ventilator-associated pneumonia accounts for 60% of healthcare-associated infection deaths. It results from invasion of the lower respiratory tract by microorganisms and affects patients 48 hours after they have been intubated and have received mechanical ventilation. Prompt diagnosis using a combination of clinical, radiographic, microbiological, and laboratory assessment can help prevent exacerbation of symptoms and provide immediate treatment. Usage of antibiotics for therapy has proven clinically useful; however, emerging resistance of microorganisms to these medications has been continuously evolving. This article focuses on amikacin and how its emerging role in treating VAP has improved patient outcomes and increased their chances of recovery with minimal adverse effects.
Non-Selective Beta-Blockers in Patients with Cirrhosis: Current Evidence and Controversy
Authors: Wang Ting , Wang Cai’e , Li Hongyu , Wang Ran
Published: June 2024

Non-selective beta-blockers (NSBBs) are the cornerstone of management of liver cirrhosis and its complications. They decrease portal vein blood flow and portal vein pressure via antagonism of β1 and β2 receptors, thereby improving the hyperdynamic circulatory status and reducing the risk of decompensated events in cirrhotic patients with portal hypertension (PH). Currently, NSBBs have been recommended for the primary and secondary prevention of variceal bleeding in patients with cirrhosis. Nevertheless, it has been noted that the clinical risk-benefit ratio appears to deteriorate for NSBBs in patients with advanced liver cirrhosis. Considering that the use of NSBBs in the clinical practice of cirrhotic patients remains controversial, this chapter aims to summarize the evidence of current recommendations and controversies regarding the use of NSBBs in patients with cirrhosis.
Significant Aspects of Heterocyclic Schiff Bases and Their Metal Complexes
Authors: Behera Nabakrushna , Behera Tankadhar , Rout Jyotiprabha , Moharana Sasmita
Published: June 2024

Schiff bases are useful precursors for the synthesis of vital pharmaceutical and biochemical compounds due to their multifunctional transformations through different processes. Indeed, the heterocyclic Schiff bases have played a unique role in coordination chemistry owing to their wide-ranging potential bio-applications, such as anticancer, antibacterial, antifungal, etc. The exploration of novel heterocyclic Schiff bases and their metal complexes has certainly been progressing because of their proven usefulness as attractive key structures for the development not only in the field of biology but also in the field of catalysis, sensing, corrosion inhibitors, etc. The unusual characteristics of heterocyclic Schiff bases have resulted in many scopes, making significant advances from both the fundamental and applied perspectives.
A Real-Life 208 Week Single-Centred, Register-Based Retrospective Study Assessing Secukinumab Survival and Long-Term Efficacy and Safety Among Greek Patients With Moderate to Severe Plaque Psoriasis, Including Difficult-to-Treat Manifestations Such as Genitals and Scalp
Authors: Kyrmanidou Eirini , Kemanetzi Christina , Stavros Chatzopoulos , Trakatelli Myrto-Georgia , Patsatsi Aikaterini , Madia Xenia , Ignatiadi Dimitra , Kalloniati Evangelia , Apalla Zoe , Lazaridou Elizabeth
Published: June 2024

Introduction: Psoriasis is a chronic inflammatory disease with multiple skin manifestations, and in case of lesions affecting the genital area sexual health impairment and psychological distress can furthermore impair the quality of life of patients. Secukinumab is a fully humanized antagonist of IL-17A and is indicated for the treatment of moderate-to-severe psoriasis. Objectives: This study was conducted in order to gather retrospective real-world data regarding the efficacy of secukinumab in treating patients with moderate-to-severe plaque psoriasis in Greece. We included difficult-to-treat manifestations in our analysis, specifically regarding the efficacy in the genital area and on the skin folds. Methods: All adult patients receiving 300 mg of secukinumab and attending follow-up visits on a regular basis, according to routine medical practice, were included. The timeline of the study was from 2015 to 2020. Primary endpoint of the study was the percentage of patients who achieved a PASI75 response rate at week 16 and week 52 post baseline.  Results: Ninety-nine patients were included in the study population. Regarding difficult-to-treat manifestations, we recorded scalp involvement in 74.74% (74/99) of our patients, genital psoriasis in 27.27% (27/99), and skin fold involvement (psoriasis inversa) in 17% (17/99). At week 16, PASI75/PASI90/PASI100 were observed in 87.5%/69.8%/49%, respectively. Treatment with secukinumab during the 208 weeks of observation did not reveal any major adverse event. Conclusion: According to our outcomes, secukinumab is an effective treatment choice for treating chronic plaque psoriasis, but additionally it can be efficacious in the subgroups of patients with difficult-to-treat manifestations.
A Systematic Review of Diagnoses With Rosettes Under Dermoscopy
Authors: Alorainy May , Buchanan Kendall , Nussinow Tyler , Rabinowitz Judy B. , Cyr Peggy , Seiverling Elizabeth V.
Published: June 2024

Introduction: Rosettes are a cluster of shiny white dots in the shape of a four-leaf clover seen under polarized dermoscopic light. Historically, rosettes were primarily reported in actinic keratoses and squamous cell carcinoma. However, rosettes have also been reported in other conditions. Objectives: The objective of this systematic review to elucidate the breadth of diagnoses exhibiting this unique dermoscopic phenomenon. Methods: A review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Literature searches were performed in MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Web of Science, as well as a manual search of the reference lists of screened articles. Results: A total of 73 articles met the inclusion criteria. Out of these, 47 distinct diagnoses with rosette were identified. Among neoplastic conditions, keratinizing neoplasms had the highest number of articles reported (n=19). Discoid lupus was the most commonly reported diagnosis within the inflammatory category (n = 6). Molluscum contagiosum was the predominant diagnosis among infectious entities (n = 3), while acroangiodermatitis was the sole diagnosis reported in the vascular category (n = 1). Conclusion: These findings confirm rosettes are not specific to keratinocytic growths and are observed in a wide range of conditions. Knowledge of the breadth of conditions with rosettes may aid clinicians when developing a differential diagnosis of a growth or an eruption with rosettes under dermoscopy.
Identifying SCC Lesions Capable of Spontaneous Regression by Using Immunohistochemistry: A Systematic Review and Meta-Analysis Study
Authors: Hedayati Maryam , Garousi Behzad , Rezaei Zahrasadat , Nazerian Yasaman , Yassaghi Younes , Tavasol Arian , Bahrami Zanjanbar Dorsa , Sharifpour Sanaz , Golestani Amir , Bolideei Mansoor , Maleki Farajolah
Published: June 2024

Introduction: Keratoacanthoma (KA) and squamous cell carcinoma (SCC) are two cutaneous conditions with morphological resemblance, which can complicate the diagnosis in some cases. Using immunohistochemistry staining of biomarkers could be beneficial in resolving this obstacle. Objectives: we investigated a variety of biomarkers assessed in different studies in order to find the most important and helpful biomarkers for differentiation between SCC and lesions capable of spontaneous regression. Methods: PubMed medical literature and Google Scholar database were used to identify relevant literature up to 15 June 2022. The aim of our analyses was to determine the capability of biomarkers to distinguish SCC from lesions capable of spontaneous regression using calculated individual and pooled OR and 95% CI and I2 tests. Results: Six potential biomarkers are CD10 with pooled OR= 0.006 (95% CI 0.001 to 0.057) and I2=0%; COX-2 with pooled OR=0.089 (95% CI 0.029 to 0.269) and I2=17.1%; Elastic Fibers with pooled OR= 6.69 (95% CI 2.928 to 15.281) and I2=0%; IMP-3 with pooled OR=0.145 (95% CI 0.021 to 1.001) and I2=44.5%; P53 with pooled OR=0.371 (95% CI 0.188 to 0.733) and I2=55.9%; AT1R with OR=0.026 (95% CI 0.006 to 0.107). Conclusions: We suggest the utilization of the following IHC biomarkers for discrimination between lesions with spontaneous regression such as KA and SCC: CD10, COX-2, and Elastic Fibers.
Intralesional Quadrivalent Human Papilloma Virus Vaccine Versus Candida Antigen in the Treatment of Multiple Recalcitrant Non-Genital Warts
Authors: Fouda Ibrahim , Mohammed Hassan Abou Khodair , Mohammed Ghada Mohammed Yousef
Published: June 2024

Introduction: Warts are the most prevalent clinical manifestation of Human papillomavirus (HPV) infections, which vary in morphological pattern depending on the site of the body affected. Objective: To evaluate the safety and efficacy of intralesional quadrivalent HPV vaccine versus candida antigen in treatment of multiple recalcitrant non-genital warts. Materials and methods: A randomized- control clinical trial included 60 cases with multiple recalcitrant warts who were randomly distributed into three groups; Group I included 20 patients who received intralesional candida antigen at a dose of 0.3 mL of 1/1000 solution, Group II included 20 patients who received intralesional quadrivalent HPV vaccine at a dose of 0.3ml and Group III included 20 patients who received intralesional injection 0.3 ml of normal saline 0.9% as a control group). Each agent was injected at the base of the largest wart every three weeks until it was completely cleared, or for a total of four sessions. Results: the highest response rate was detected in the quadrivalent HPV vaccine group (75% complete response) followed by the candida vaccine group (40% complete response and 15% partial response). Also, regarding the distant response rate, the highest response rate was detected in the quadrivalent HPV vaccine group (72.7% complete response and 27.3 % partial response) followed by the candida vaccine group (33.3 % complete response and 50 % partial response). Conclusion: Intralesional immunotherapy appears to be effective and safe in treating multiple recalcitrant non-genital warts, with intralesional quadrivalent HPV vaccine outperforming intralesional candida antigen.
Impact of Vitiligo on Quality of Life in Patients of Skin of Color and Its Correlation With Clinical Severity Assessment Scores Utilizing Disease Specific Scores: a Cross-Sectional Study
Authors: Awal Guneet , Kaur Navleen , Singh Guramrit , Sharma Nishant
Published: June 2024

Introduction: Assessment of disease severity of vitiligo is exigent as it is a psychosomatic ailment. VIDA (vitiligo disease activity score) and VASI (vitiligo area severity index) were previously used for this evaluation. Recently, the introduction of two vitiligo specific tools, vitiligo impact scale (VIS)-22 and Vitiligo Quality of Life Index (VitiQoL) has aided in assessing the quality of life (QOL) in a pertinent manner. Objectives: To measure the QOL in vitiligo using disease specific indices (VitiQoL and VIS-22), to assess their relationship with disease severity (VASI and VIDA) and to determine the correlation between QOL scores (VIS-22 and VitiQoL). Methods: This observational cross-sectional study included 195 patients with vitiligo, and their disease severity was calculated using VASI and VIDA scoring. Patients were asked to fill questionnaires for assessing the QOL using validated tools ie VIS-22 and VitiQoL. Results: Significant correlation was demonstrated between both QOL scores and VASI score (P value 0.001) with slightly higher values for VitiQoL (r = 0.824) than with VIS 22 (r = 0.693). Both scores exhibited a significant association with VIDA score (P value < 0.001). Moreover, statistically significant correlation was found between VIS-22 and VitiQoL, thereby proving the concordance between these scores. Conclusions: The study infers that QOL seemed to be remarkably dependent on the clinical severity scores and that higher disease activity corresponds to poorer QOL. It is imperative to precisely assess burden of vitiligo and the impairments caused by it in order to aid multi-modality management and allow more standardized research.
Dermoscopic Features of Pigmented Bowen Disease: A Multicenter Study on Behalf of the Ibero-Latin American College of Dermatology (CILAD)
Authors: Cabo Horacio , Salerni Gabriel , Cohen Sabban Emilia , Bollea Garlatti Agustín , Orendain Nicole , Rodriguez Saa Sonia , Marchiori Bakos Renato , Pozzobon Flavia Carolina , Gonzalez Virginia Mariana , Peralta Rosario , Navarrete-Dechent Cristian , Peirano Dominga , Pérez-Hernández Elia , Puig Susana
Published: June 2024

Introduction: Studies focused on dermoscopic aspects of pigmented Bowen disease (pBD) in Latin American population are scarce and limited to only case reports or small series. Objectives: To report dermoscopic findings in a large series of 147 pBD diagnosed in Ibero-Latin American population. Methods: We conducted a multicentric, retrospective study on 147 histologically proven pBD under the auspices of the Dermoscopy Chapter of the Ibero-Latin American College of Dermatology. Results:  The study population consisted of 77 females (52%) and 70 males (48%) with a mean age of 68.6 years. 70.1% of patients had skin phototype 3, 15.6% to skin phototype 2, and 14.3% to skin phototype 4. On clinical examination, near 60% of pBD were flat, 70% presented with scales, and 90% were asymmetric. Under dermoscopy, structureless hypopigmented areas, dots brown and pink color were the most frequently observed. Regarding specific dermoscopic clues to pBD, the most prevalent were structureless hypopigmented areas, vessels arranged in linear fashion at the periphery, and pigmented lines or pigmented dots distributed in a linear fashion. Clustered, coiled, and dotted vessels were observed in 55.8%, 45.6%, and 45.6% of the cases, respectively. Conclusions: We report a large series of cases of pBD in Latin American patients, with most patients being skin phototype 3 and 4. Distinctively in our study, the pigmented structures and the clues derived from the presence of melanin were much more frequent than in previous reports in fair skin.
Một số nghiên cứu nổi bật về rối loạn nhịp tim năm 2023
Authors: Phạm Trần Linh , Vũ Huy Thành , Trần Song Giang , Phan Đình Phong
Published: June 2024

Trong năm 2023, sau khi kết thúc đại dịch COVID 19, lĩnh vực nghiên cứu về rối loạn nhịp tim đã bùng nổ với hàng ngàn nghiên cứu trên Thế giới được báo cáo trực tiếp hoặc, poster tại nhiều hội nghị lớn về nhịp tim trên thế giới như: Hội nghị khoa học nhịp tim thường niên Châu Âu (EHRA 2023), Hội nghị khoa học lần thứ 44 Hội Nhịp tim Hoa Kỳ (HRS 2023), Hội nghị Nhịp tim thường niên Châu Á – Thái Bình Dương (APHRS 2023)… Trong bài báo này, chúng tôi muốn giới thiệu 03 nghiên cứu tiêu biểu trong các nghiên cứu về lĩnh vực rối loạn nhịp tim đã được trình bày trong các Hội nghị Nhịp tim năm 2023.
Khuyến cáo của Hội Tim mạch Châu Âu – điểm nhấn trong lĩnh vực quản lý bệnh cơ tim năm 2023
Authors: Đỗ Thúy Cẩn , Đỗ Kim Bảng , Nguyễn Thị Thu Hoài
Published: June 2024

Năm 2023 là một năm đáng ghi nhớ với sự ra đời của khuyến cáo đầu tiên tổng hợp về các bệnh lý cơ tim do Hội Tim mạch Châu Âu ban hành vào tháng 11. Tuy khuyến cáo này không thay thế hoàn toàn các hướng dẫn xử trí chuyên biệt cho từng bệnh lý cơ tim cụ thể (như khuyến cáo về bệnh cơ tim phì đại của Hội Tim mạch Hoa Kỳ và Trường môn Tim mạch Hoa Kỳ – AHA/ACC – năm 2020 hay các đồng thuận về quản lý bệnh cơ tim thất phải do rối loạn nhịp của Hội nhịp học Hoa Kỳ – HRS – 2019,…) nhưng nó đóng vai trò như một tài liệu tổng hợp đầu tiên hướng dẫn việc chẩn đoán, điều trị và quản lý của các bệnh cơ tim. Bài viết này sẽ điểm lại một số nét mới trong khuyến cáo trên của Hội Tim mạch Châu Âu.
Thuyên tắc động mạch phổi cấp: Kỳ vọng nào sau năm 2023
Authors: Nguyễn Tuấn Hải , Văn Đức Hạnh , Tạ Mạnh Cường
Published: June 2024

Thuyên tắc động mạch phổi cấp là một cấp cứu tim mạch, với tỷ lệ tử vong trong bệnh viện cao, và vẫn chưa có xu hướng giảm theo thời gian. Đã có nhiều khuyến cáo quốc tế, và quốc gia trong thời gian gần đây, cập nhật những tiến bộ mới nhất trong chẩn đoán, điều trị và dự phòng thuyên tắc huyết khối tĩnh mạch nói chung, và thuyên tắc phổi cấp nói riêng. Tuy nhiên, quản lý thuyên tắc phổi cấp vẫn còn nhiều thách thức. Sự phát triển mạnh mẽ của khoa học và công nghệ đã mở ra những hy vọng mới cho  bệnh nhân thuyên tắc phổi cấp, từ việc áp dụng trí tuệ nhân tạo trong chẩn đoán sớm và phân tầng nguy cơ, đến sự xuất hiện của thuốc chống đông thế hệ mới, có hiệu quả điều trị tương tự các thuốc chống đông hiện hành, nhưng an toàn hơn; và vai trò ngày càng quan trọng của các phương pháp can thiệp tái tưới máu động mạch phổi, dự báo khả năng bổ sung, thậm chí thay thế phương pháp tái tưới máu toàn thân bằng thuốc tiêu sợi huyết.
An exploratory study of factors influencing manufacturer-dealer relationship in Indian automobile industry
Authors: Sujay Bhalchandra  , Nilesh D. Shinde
Published: June 2024

The purpose of this study is to explore critical factors that define the level of satisfaction and bond of relationship between automobiles companies and their dealerships. Indian automobile industry is one of the world’s fastest growing industries and the success of auto companies is largely depends on their robust and healthy dealer network. In this paper, we attempt to identify critical factors which can influence the relationship of manufacturers and dealers. The research is based on a survey carried out in the Pune region of Maharashtra, where we focused on identified critical factors of mutual relationship. It was also noted that new-age auto dealership owners are looking forward to relationships beyond just return on Investment. Using statistical data analysis, we also attempt to identify the most critical factors that can influence dealer-original equipment manufacturer relations. These factors were return on investment, future growth potential, support from the OEM team, involvement in policy decision-making making and supply of quality products. The results also indicate the roles and responsibilities of an OEM in building strong relationships with its dealers to improve sales.
The impact of online degree programs on employment opportunities in contemporary India
Authors: Santosh T. Karmani  , Sachin V. V. Acharekar
Published: June 2024

The contemporary global economy demands a highly skilled and adaptable workforce, yet a persistent gap persists between the skills sought by employers and those possessed by the workforce. Online degree programs have emerged as a transformative solution, offering accessible and flexible pathways for individuals to acquire the skills necessary to meet the demands of the modern job market. However, despite their growing popularity, there remains a research gap in understanding their effectiveness, particularly in India. This research aims to evaluate the effectiveness of online degree programs in bridging the skills gap, preparing students for the workforce, and assessing the relevance of their curricula in meeting contemporary job market demands, particularly in India. The study employs a mixed-methods approach, including surveys with educators, students, and employers, as well as interviews with industry experts. The findings reveal that online degree programs play a significant role in closing the skills gap and fulfilling job market demands in contemporary India. The curricula of these programs are highly relevant and aligned with industry needs, offering practical learning experiences that enhance students’ employability. Moreover, online education provides an inclusive, flexible, and cost-effective approach to education, enabling individuals from diverse backgrounds to access quality education. Overall, this research underscores the importance of online degree programs in preparing individuals for success in a rapidly changing and competitive global economy. By leveraging the full potential of online education, we can create a workforce that is well-equipped to meet current industry needs and adapt to the challenges of the future.
A comprehensive review of urban growth studies and predictions using the Sleuth model
Authors: Dey Bratati , Sharma Poonam
Published: June 2024

Urban growth is a complex phenomenon It has been the subject of in-depth research for the last few years. There are various models used to measure and simulate urban growth. Most of these methods are founded on GIS & RS techniques coupled with the CA algorithm, as only these tools and techniques have the capabilities to conduct spatiotemporal studies, manage spatiotemporal dynamics, and provide a detailed depiction and modeling from the bottom-up tactic. Recently, the slope, land use, exclusion, urbanization, transportation, and hill shade (SLEUTH) model has been the most commonly used model. It is easily accessible because it is open source; moreover, its source code is also easily accessible. The SLEUTH model’s name alludes to the necessary inputs —slope, land use, excluded area, urban extension, transportation, network and hillshade. The model has been used in many cities and has proven to be efficient. The present review paper reviews the past literature pertaining to urban development and prediction to further support the research on urban planning, urban growth and prediction.
CHEMICAL STABILITY OF DRUGS
Authors: Mukati Sandeep , Khan Shahrukh , Gupta Dr. Ravikant , Vengurlekar Dr. Sudha
Published: June 2024

The chemical stability of drugs plays a pivotal role in the pharmaceutical industry, impacting drug development, manufacturing, storage, and ultimately, patient safety. This abstract explores the key aspects of chemical stability, emphasizing its significance in drug formulation and quality control. Chemical stability refers to a drug's ability to maintain its chemical composition and therapeutic efficacy over time, despite exposure to various environmental factors. Temperature, humidity, pH, light, and the presence of impurities are among the critical factors influencing a drug's stability. The deviation from stability can lead to decreased potency, changes in pharmacokinetics, and the formation of potentially toxic degradation products, posing risks to patients. Stability testing is a systematic process that assesses how different conditions affect a drug product over time. It employs analytical techniques to monitor changes in the drug's chemical and physical properties. These studies provide essential data for determining a drug's shelf life, recommended storage conditions, and appropriate packaging materials. The chemical stability of drugs is a fundamental element in pharmaceutical science, underpinning the quality, safety, and efficacy of medications. Rigorous stability testing is essential in drug development and regulatory approval, guaranteeing that patients receive safe and effective therapies. As the field continues to evolve, an enhanced understanding of drug stability contributes to the development of more durable, reliable pharmaceutical products.
PHARMACOKINETICS
Authors: Jaiswal Pooja , Gupta Dr. Ravikant , Vengurlekar Dr. Sudha , Jaiswal Dr. Shikha
Published: June 2024

Pharmacokinetics is the branch of pharmacology that focuses on the study of how drugs move within the body. It include the processes of drug absorption, distribution, metabolism, and elimination, collectively known as ADME. The main objective of pharmacokinetics is to quantitatively describe the time course and extent of drug concentration at different sites within the body, such as blood plasma, tissues, and organs. This knowledge helps in predicting the drug therapeutic effect, as well as potential side effects and interactions with other drugs. The pharmacokinetic parameters commonly studied include absorption rate, distribution volume, clearance, half-life, and bioavailability.
RECENT BREAKTHROUGH IN ANTICANCER ACTION OF HETEROCYCLES
Authors: Singh Ayushi , Mishra Rakhi , Mazumder Avijit
Published: June 2024

The recent ground-breaking discoveries in the field of anticancer research are examined in this chapter, with a special emphasis on the extraordinary potential of heterocycles. Heterocycles, a group of chemical molecules with ring structures including atoms other than carbon, have shown promise as a source of new and effective anticancer drugs. The important discoveries and developments in exploiting the anticancer properties of heterocycles are succinctly summarized in the abstract. Recent research has revealed the wide range of biological activities exhibited by heterocyclic substances, emphasizing their capacity to disrupt vital molecular pathways involved in cancer cell survival and proliferation. Scientists can create tailored medicines using their distinctive chemical structures, which have the potential to successfully treat cancer while minimizing collateral damage to healthy cells. Combination therapies that combine heterocyclic compounds with traditional anticancer medications have also shown promise in overcoming drug resistance and boosting therapeutic efficacy. This tactical strategy opens a promising new path for developing cancer therapy protocols and enhancing patient outcomes. A thorough understanding of the safety profiles, pharmacokinetics, and long-term consequences of heterocycles is still required despite the significant progress achieved in harnessing their anticancer properties. To turn these ground-breaking findings into useful therapeutic applications, the chapter emphasizes the necessity of ongoing collaborations between researchers, physicians, and pharmaceutical corporations
EROTICA ON-SCREEN: SOCIOLOGICAL ANALYSIS OF BOLLYWOOD MOVIES FROM 1940S TO 2015
Authors: Dutta Sayanti
Published: June 2024

Movies are addressed as the vintage point of India's culture and tradition. One of the important and famous genres used by the popular Bollywood movies is romanticism and love which is expressed to the spectators through the means of erotic content. In the words of a famous ‘French director Jean-Luc Godard, “all you need for a movie is a gun and a girl”’ (Danesi, 2015), he essentially point towards two important components of popular cinema, that is, violence and sex or erotica. Eroticism’ which had always been referred to as private and a taboo to talk about is the center of attraction for the new generation. Eroticism is portrayed and constructed in the movies to express romance in between two individual. This portrayal and construction of eroticism has undergone several changes from its initiation to the present day. The present study uses a qualitative approach using critical sociological perspectives to analyze seventeen popular Bollywood cinemas over a time period of almost eighty years, 1940s to 2015. Three popular movies on an average are analyzed in a single time interval of twenty years. The present study aims at understanding the major research questions which includes erotica, its constructed onscreen meaning and its onscreen acceptance among the spectators. It is observed that the concept of premarital sex has been introduced in the popular movies from 1980s onward, along with it, the aspect that movies use erotica to construct romance is also changing Irrespective of these changes in perspectives, the movies are popular to its spectators, because these movies meet their unfulfilled desires and fulfills their sexual libido, thus satisfying them visually.
INTERNAL AUDITOR’S PIVOTAL ROLE IN ESG REPORTING: FROM CONFUSION TO CONVERGENCE
Authors: Nag Dr. Amit Kumar , Dubey Dr. Atul , Joshi Dr. Rahul
Published: June 2024

We are in a pivotal period of profound transformations and unparalleled possibilities. The survival and prosperity of the human race hinge on the conservation of planet Earth in its pristine form. To realize this, ESG principles must be deeply ingrained in the core ethos of organizations worldwide. ESG, therefore, must evolve beyond mere letters in the alphabet, restricted to discussions in conferences, academic articles, and polished annual reports. To ensure ESG doesn't remain just ornamental jargon, periodic reviews of its practices are paramount. To facilitate these reviews, a comprehensive evaluation system with criteria for environmental, social, and governance aspects is crucial. This is where the role of an internal auditor becomes indispensable.
N-n-HEPTYLANILINE AS A NEW REAGENT FOR THE LIQUID-LIQUID EXTRACTION OF THALLIUM (III)
Authors: Pawar R. R. , Suryavanshi V. J. , Patil M. M. , Mulik A. G. , Patil S. S. , Mulik G. N.
Published: June 2024

The present study is concerned with the simple solvent extraction of thallium(III) from mineral acid media with N-n-heptylaniline in xylene is reported in this paper. Thallium(III) was back extracted with acetate buffer (pH = 4.63). The effect of acid and extractant media, role of various diluents, stripping agents, loading capacity, aqueous to organic volume ratio, equilibrium time, temperature effect on extraction of thallium(III) has been studied. The stoichiometry of extracted species was determined on the basis of slope analysis method. The method was free from interference of large number of cations and anions. The method was used for selective extraction of thallium(III) from its binary mixture. The proposed method was used for the analysis of synthetic mixtures and real sample like alloy. It is rapid and selective method.
ORIGIN AND GENERAL APPEARANCES OF ENGLISH LANGUAGE
Authors: M. Patel Dr. Hitendrakumar
Published: June 2024

Language is God’s special gift to mankind. Language is a means of communication, and storehouse of knowledge, it is an instrument of pleasure and sorrow. Without language, man would have remained only a dumb animal. Patanjali, the linguist, says “Language is that human expression which is uttered out by speech organs”. In the Encyclopedia Britannica, “Language defined as a system of conventional spoken or written symbols through which human beings, as members of a social group particulars in its culture, communicate.” English is the most popular of the world languages. It has been widespread almost in all countries of the world. Some of the commonwealth countries have given it importance of a second national language. English language as it exists today, has great potential for becoming an international medium of communication.