bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Petrographic Characteristics and Provenance for the Rock Properties from Dorim-ri Tombs of Baekje Kingdom in Cheonan, Korea
Authors: Lee Chan Hee , Cho Jihyun , Park Sung Mi
Published: November 2021

We analyzed the provenance and petrographic characteristics for the rock properties from stone-lined tomb and stone chamber tomb at the Dorim-ri site of the Baekje Kingdom, located in Cheonan. The two tombs consist of 10 kinds of rocks including gneiss, diorite, and andesite. The major rock type is gneiss (54.3%), which composes the main chamber walls of the tombs. Diorite (11.3%) and andesite (10.6%) also make up a large percentage of the rocks, tending to be used to fill the space between the main chamber walls. Thus, the stones appear to have been used according to their shape and the disposition of the site, respectively. Investigation of their provenance, confirmed their source area to be near the Ipjang Reservoir, about 1 km away from the site, and their procurement was probably conducted via a waterway. This result might serve as basic data regarding the material procurement system of ancient tomb culture and for preservation measures for archaeological sites.
Scientific Analysis and Conservation of Waterlogged Woods Excavated from Suyoeng-ri Site, Hwaseong, Korea
Authors: Lee Kwang-Hee , Oh Jeong-Eun , Kim Soo-Chul
Published: November 2021

Five waterlogged wood artefacts were excavated from Suyeong-ri site in Hwaseong, South Korea. The aim of the present study was to identify the species and estimate the date of manufacture and the manufacturing method of these artefacts. The study also aimed to conserve the original shapes of waterlogged wood artefacts by using the vacuum freeze drying method. The two large waterlogged woods were identified as Ulmus spp. and Morus spp., whereas one of the three small waterlogged woods was identified as Abies spp. and the other two as hard pine. Radiocarbon dating using wiggle match dated the manufacturing of these wooden artefacts between BCE 8520-8490 or BCE 8470-8290 in the Neolithic age, and a similar period was also confirmed for seed excavated from a place close to the location where the waterlogged wood artefacts were excavated. The surface of waterlogged wood artefacts had several traces of manufacturing processes - traces of tearing and chopping - were observed. Based on these observations, it was confirmed that stone adz was used to make these wooden artefacts. Thereafter, the waterlogged wood samples were conserved by immersing them into PEG#4,000 of concentration in water from 10% to 40% at room temperature(15~25℃) and subjecting them to vacuum freeze drying. However, the internal moisture was not completely removed in some thick parts of waterlogged woods by applying the general schedule such as raising the shelf temperature as the surface temperature rises. Therefore, additional study is required using the schedule-method for vacuum freeze drying of large waterlogged wood.
The northern Thessaly strong earthquakes of March 3 and 4, 2021, and their neotectonic setting
Authors: Chatzipetros Alexandros , Pavlides Spyros , Foumelis Michael , Sboras Sotiris , Galanakis Dimitris , Pikridas Christos , Bitharis Stylianos , Kremastas Evangelos , Chatziioannou Athanasios , Papaioannou Ioannis
Published: November 2021

A sequence of earthquakes occurred on March 3rd and 4th in Northern Thessaly, northern Greece, associated with previously unknown, blind normal faults within the crystalline Palaeozoic basement of the Pelagonian geotectonic zone. Surficial ground deformation, such as liquefaction phenomena in fluvial plains, as well as soil fissures and rock falls, have been mapped. Geological indications of the unmapped seismic fault, i.e., reactivated shear zones, open cracks, etc., have been identified within the bedrock. Based on geological indications, the main fault projection to the surface could be considered a 15 km NW-SE trending structure and average dip of 45o to the NE. The seismic source of the main shock was modelled, and the Coulomb static stress changes calculated for receiver faults similar to the source. The determination of the active tectonic regime of the region by geodetic data and the well-known faults of NE Thessaly plain are also presented, as well as the revised historical and instrumental seismicity. This earthquake raises new concerns and challenges, revising some established views, such as the status of main stress orientations, the orientation of active tectonic structures, the occurrence of a seismogenic fault in a mountainous massif of crystalline rocks without typical geomorphological expression and the role of blind faults in Seismic Hazard Assessment.
Πρόσωπο, ετερότητα και κοινωνία στους Εmmanuel Levinas και Ιωάννη Ζηζιούλα (Μητροπολίτη Περγάμου)
Authors: Γκάνεφ Μάρτιν
Published: November 2021

Η παρούσα διδακτορική διατριβή αποπειράται να απαντήσει στο υπαρξιακό ερώτημα μιας οντολογικής ηθικής. Ο Εμ. Λεβινάς αντιτάσσεται στην «προφητεία» του Χάιντεγκερ περί του τέλους της μεταφυσικής, και πιστεύει ότι ή μεταφυσική μπορεί να πραγματοποιηθεί και ολοκληρωθεί στη σχέση με το Άλλο ον, με τον Άλλον, και αυτή ή μεταφυσική που γεννιέται στον χώρο του κοινωνικού πεδίου και της ηθικής, προηγείται της κατανόησης του είναι και επιβιώνει της οντολογίας. Από την άλλη πλευρά έχουμε ένα σύγχρονο θεολόγο ο οποίος κατηγορηματικά εντάσσεται στη χορεία αυτών που δίνουν στην οντολογία έναν προσωπικό προσανατολισμό. Ο Μητροπολίτης Περγάμου Ιωάννης Ζηζιούλας είναι από τούς πρωτεργάτες της οντολογικής στροφής, στο πεδίο της θεολογίας. Ο ίδιος πιστεύει ότι ή δομή της σκέψης μας πρέπει να είναι οντολογική και ή θεολογία είναι εκείνη που μπορεί να δώσει ορθό περιεχόμενο στην οντολογία. Με άλλα λόγια, ο Ιωάννης Ζηζιούλας προσπαθεί να απελευθερώσει τη θεολογία από τον φόβο της μεταφυσικής οντολογίας προσδίδοντας έναν υποστασιακό και εσχατολογικό προσανατολισμό. Υπάρχει και ένα κοινό σημείο στις απόψεις τους, και αυτό είναι πρώτα το ενδιαφέρον και φροντίδα τους για τον σύγχρονο άνθρωπο και δεύτερο ή δέσμευσή τους ως προς την οντολογία.
Processes for updating guidelines: protocol for a systematic review
Authors: Cardwell Karen , Quigley Joan , Clyne Barbara , Tyner Barrie , Carrigan Marie , Smith Susan , Ryan Máirín , O'Neill Michelle
Published: November 2021

Background: National Clinical Guidelines are systematically developed statements, based on a thorough evaluation of the evidence, to assist practitioner and service users’ decisions. Clinical guidelines require updating to ensure validly of the recommendations contained within. The purpose of this systematic review is to describe the most recent guideline update processes, including prioritisation methods, used by international or national groups who provide methods guidance for developing and updating clinical guidelines.

Methods: A combination of searching a pre-defined list of international and national organisations that provide methods guidance for developing and updating clinical guidelines, together with grey literature searching, will be undertaken to identify relevant handbooks. This will be supplemented by a systematic literature search of Medline (EBSCO), Embase (OVID) and The Cochrane Methodology Register. As guideline development methodology has evolved considerably, the overall search span for this systematic review will be the last 10-years (2011-2021). Publications eligible for inclusion are methodological handbooks that provide updating guidance, including prioritisation methods, for clinical practice guidelines and peer-reviewed articles that describe or have implemented updating guidance, including prioritisation methods. Using Covidence, two reviewers will independently review titles/abstracts and full texts. Where disagreements occur, discussions will be held to reach consensus and where necessary, a third reviewer will be involved. Methodological handbooks will be quality assessed (using the GIN-McMaster Guideline Development Checklist) independently by two reviewers and any disagreements will be resolved by deliberation, or if necessary, a third reviewer. Data will be extracted by one reviewer and checked for inaccuracies/omissions by a second. A narrative synthesis will be undertaken.

Conclusions: Updating clinical guidelines is an iterative process that is both resource intensive and time-consuming. The findings of this systematic review will support clinical guideline developers to ensure appropriate investment of resources.
Managing anaphylaxis in adults
Authors: Curry Sam
Published: November 2021

Anaphylaxis is a severe and potentially life-threatening allergic reaction. The recognition and treatment of anaphylaxis remains complex and an area of continued professional development for health professionals. Prompt recognition of anaphylaxis and its subsequent treatment and management by the multidisciplinary team, including nurses and allied health professionals, is key as this increases the patient's chances of survival. Evidence-based clinical information on managing anaphylaxis will enable health professionals to provide safer patient care.
Intra-articular administration of vancomycin and tobramycin during primary cementless total knee arthroplasty
Authors: Lawrie Charles Murray , Kazarian Gregory S. , Barrack Toby , Nunley Ryan M. , Barrack Robert L.
Published: November 2021

Aims

Intra-articular administration of antibiotics during primary total knee arthroplasty (TKA) may represent a safe, cost-effective strategy to reduce the risk of acute periprosthetic joint infection (PJI). Vancomycin with an aminoglycoside provides antimicrobial cover for most organisms isolated from acute PJI after TKA. However, the intra-articular doses required to achieve sustained therapeutic intra-articular levels while remaining below toxic serum levels is unknown. The purpose of this study is to determine the intra-articular and serum levels of vancomycin and tobramycin over the first 24 hours postoperatively after intra-articular administration in primary cementless TKA.

Methods

A prospective cohort study was performed. Patients were excluded if they had poor renal function, known allergic reaction to vancomycin or tobramycin, received intravenous vancomycin, or were scheduled for same-day discharge. All patients received 600 mg tobramycin and 1 g of vancomycin powder suspended in 25 cc of normal saline and injected into the joint after closure of the arthrotomy. Serum from peripheral venous blood and drain fluid samples were collected at one, four, and 24 hours postoperatively. All concentrations are reported in µg per ml.

Results

A total of 22 patients were included in final analysis. At one, four, and 24 hours postoperatively, mean (95% confidence interval (CI)) serum concentrations were 2.4 (0.7 to 4.1), 5.0 (3.1 to 6.9), and 4.8 (2.8 to 6.9) for vancomycin and 4.9 (3.4 to 6.3), 7.0 (5.8 to 8.2), and 1.3 (0.8 to 1.8) for tobramycin; intra-articular concentrations were 1,900.6 (1,492.5 to 2,308.8), 717.9 (485.5 to 950.3), and 162.2 (20.5 to 304.0) for vancomycin and 2,105.3 (1,389.9 to 2,820.6), 403.2 (266.6 to 539.7), and 98.8 (0 to 206.5) for tobramycin.

Conclusion

Intra-articular administration of 1 g of vancomycin and 600 mg of tobramycin as a solution after closure of the arthrotomy in primary cementless TKA achieves therapeutic intra-articular concentrations over the first 24 hours postoperatively and does not reach sustained toxic levels in peripheral blood. Cite this article: Bone Joint J 2021;103-B(11):1702–1708.
Leg length discrepancy in patients with Perthes’ disease
Authors: Tolk Jaap J. , Eastwood Deborah M. , Hashemi-Nejad Aresh
Published: November 2021

Aims

Perthes’ disease (PD) often results in femoral head deformity and leg length discrepancy (LLD). Our objective was to analyze femoral morphology in PD patients at skeletal maturity to assess where the LLD originates, and evaluate the effect of contralateral epiphysiodesis for length equalization on proximal and subtrochanteric femoral lengths.

Methods

All patients treated for PD in our institution between January 2013 and June 2020 were reviewed retrospectively. Patients with unilateral PD, LLD of ≥ 5 mm, and long-leg standing radiographs at skeletal maturity were included. Total leg length, femoral and tibial length, articulotrochanteric distance (ATD), and subtrochanteric femoral length were compared between PD side and the unaffected side. Furthermore, we compared leg length measurements between patients who did and who did not have a contralateral epiphysiodesis.

Results

Overall, 79 patients were included, of whom 21 underwent contralateral epiphysiodesis for leg length correction. In the complete cohort, the mean LLD was 1.8 cm (95% confidence interval (CI) 1.5 to 2.0), mean ATD difference was 1.8 cm (95% CI -2.1 to -1.9), and mean subtrochanteric difference was -0.2 cm (95% CI -0.4 to 0.1). In the epiphysiodesis group, the mean LLD before epiphysiodesis was 2.7 cm (95% CI 1.3 to 3.4) and 1.3 cm (95% CI -0.5 to 3.8) at skeletal maturity. In the nonepiphysiodesis group the mean LLD was 2.0 cm (95% CI 0.5 to 5.1; p = 0.016). The subtrochanteric region on the PD side was significantly longer at skeletal maturity in the epiphysiodesis group compared to the nonepiphysiodesis group (-1.0 cm (95% CI -2.4 to 0.6) vs 0.1 cm (95% CI -1.0 to 2.1); p < 0.001).

Conclusion

This study demonstrates that LLD after PD originates from the proximal segment only. In patients who had contralateral epiphysiodesis to balance leg length, this is achieved by creating a difference in subtrochanteric length. Arthroplasty surgeons need to be aware that shortening of the proximal femur segment in PD patients may be misleading, as the ipsilateral subtrochanteric length in these patients can be longer. Therefore, we strongly advise long-leg standing films for THA planning in PD patients in order to avoid inadvertently lengthening the limb. Cite this article: Bone Joint J 2021;103-B(11):1736–1741.
Vertical Electrical Sounding Analysis for Local Subsurface Water Bearing Identification Due to Isolated Hill. Case-study: Madurejo Village, Prambanan District, Yogyakarta Province, Indonesia
Authors: Hartantyo Eddy
Published: November 2021

In a subsurface aquifer, there is a ‘barrier like’ phenomenon that blocks the flow of water. It will create a subsurface water bearing/dam and potential source for water well drilling. The existence of clay-limestone in the isolated hill in Madurejo village, Prambanan district, Yogyakarta seems to act like a natural groundwater body which is interesting to be analyzed by means of vertical electrical sounding (VES). For this purpose, three VES points measured with 150 meters apart, creating a line from south to north. Maximum distance for AB is 200 meters. We found the shallow unconfined from surface to 4 m depth and confined aquifers from 6 m to 29 m. The geometry of the second aquifer in combination with the existence of isolated hill seems to have a water-bearing structure which is very potential for water resources.
Ionic Silver Nanoparticles (Ag+) Sebagai Bahan Antibiotik Alternatif Untuk Salmonella Typhymurium
Authors: Palupi Saraswati Kendis Intan , Suparno Suparno
Published: November 2021

This study aims to determine the ability of ionic silver nanoparticles (ISN) Ag+ as an antibiotic material to inhibit the growth of Salmonella typhimurium. ISN are produced by electrolysis using two AgBr bars as electrodes with distilled water as electrolyte solvents. The effect of electrolysis time on ISN concentration and electrical conductivity was observed with a TDS and EC meter. All ISN samples have been characterized by UV-Vis spectrophotometer, AAS, and PSA. The results showed the concentration of ISN and the electrical conductivity of the solution increased with the length of time of electrolysis. UV-Vis spectrophotometer test results have shown the peak of absorbance at a wavelength of 416.5-417 nm. The concentration test using AAS has shown that the concentration of ISN for TDS 11 ppm, 20 ppm and 29 ppm is 9.8 ppm, 17.6 ppm, and 23.9 ppm respectively. While the size of silver nanoparticles PSA test results have shown (76.8 ± 0.667) nm. The results of the test of the ability of ISN as an antibiotic Salmonella typhimurium showed the formation of a clear zone until the 72th hour with the largest average diameter in the stationary phase area (hours 24-72) was 7.39 ± 0.04 mm for a concentration of 20 ppm.
Rancang Bangun Sistem Ultrasound Assisted Extraction (UAE) dengan Otomasi Pengaturan Suhu dan Volume Pelarut
Authors: Ayu Humairoh Ratu , Suryono Suryono , Suseno Jatmiko Endro
Published: November 2021

Pada penelitian ini telah dilakukan rancang bangun sistem pengaturan suhu dan volume pelarut pada ultrasound assisted extraction. Sistem ini terdiri dari pompa, mikrokontroler, termocouple, termocontroller dan sensor suhu LM35 yang bertujuan untuk menghindari pengenceran ekstrak dan meningkatkan transfer massa sehingga mendapatkan hasil ekstraksi yang lebih baik. Pompa menyala sesuai dengan perintah yang diberikan ke mikrokontroler selanjutnya dilakukan pembacaan nilai ADC oleh sensor suhu LM35 yang kemudian dikonversi ke dalam nilai temperatur. Berdasarkan hasil penelitian yang telah dilakukan, sistem mampu mengontrol volume pelarut dengan nilai error sebesar 2,38%, memantau suhu dalam wadah ekstraksi menggunakan sensor suhu LM35 dengan nilai error sebesar 0,70% dan mengontrol suhu menggunakan termokontroler dengan kestabilan sistem sebesar 96,16%.
Deteksi Kantuk Menggunakan Jaringan Saraf Tiruan Radial Basis Function dan Particle Swarm Optimization dengan RR Interval Elektrokardiogram
Authors: Shalihah Ariefah , Nuryani Nuryani , Sutomo Artono Dwijo
Published: November 2021

Sistem deteksi kantuk dirancang menggunakan Elektrokardiogram (EKG) dengan Jaringan Saraf Tiruan Radial Basis Function dan Particle Swarm Optimization (JST RBF-PSO). Karolinska Sleepiness Scale (KSS) menjadi acuan tingkat kantuk yang dikelompokkan menjadi kelas terjaga dan kelas mengantuk. Sistem ini menggunakan algoritma Pan-Tomkins untuk menentukan interval RR dari EKG. Fitur yang digunakan adalah 15 parameter fitur statistik. Pelatihan dan pengujian data menggunakan JST RBF-PSO dengan metode validasi silang. PSO digunakan untuk mengoptimasi parameter utama JST RBF yaitu bobot, pusat dan lebar. Sistem deteksi kantuk ini diuji menggunakan DROZY Database. Hasil penelitian menunjukkan akurasi sistem ini pada segmentasi 40 detik, jumlah neuron 150 dan 15 fitur statistik sebesar 88,36%.
Pengaruh Doping Nikel dan Suhu Sinter pada Pembuatan Kawat Superkonduktor Magnesium Diborida
Authors: Herbirowo Satrio , Hanafi M Nur , Imaduddin Agung , Utomo Edy Priyanto , Hendrik Hendrik , Trenggono Aditya , Yustanti Erlina
Published: November 2021

Peningkatan sifat superkonduktor MgB2 melalui penambahan doping telah banyak dilakukan. Meskipun begitu, pembuatan kawat superkonduktor MgB2  belum secara optimal dihasilkan akibat porositas yang terbentuk dari struktur lapis MgB2. Tujuan penelitian ini adalah untuk menganalisis efek penambahan doping nikel terhadap nilai kristalinitas dan kepadatan serta temperatur optimum dalam sintesis kawat superkonduktor berbasis MgB2. Variabel proses pada sampel yang digunakan yaitu variasi persen berat doping Nikel dan temperatur sintering. Karakterisasi   yang   digunakan   meliputi   Xray   Diffraction   (XRD),   Scanning   Electron Micoscope-Energy Dispersive Spectroscopy (SEM-EDS), dan Cryogenic Magnet. Pembuatannya menggunakan proses metalurgi serbuk dengan metode powder in tube secara in-situ dan manufaktur pengerolan kawat. Pengerolan dilakukan reduksi ukuran diameter 6 mm menjadi 4 mm, serta panjang awalnya 10 cm menjadi ±26 cm. Dari hasil XRD menunjukkan bahwa sampel dengan doping nikel menghasilkan fasa primer MgB2  dan fasa sekunder MgNi2.5B2  serta beberapa pengotor (MgO dan Mg) dengan ukuran kristalit lebih meningkat dibandingkan MgB2 tanpa doping. Dari gambar SEM, sampel tampak menunjukkan penurunan jumlah porositasnya. Sampel yang disinter 750°C merupakan temperatur optimal dalam  mensintesis superkonduktor MgB2   yang  didoping nikel  karena  memiliki  Tc  onset tertinggi sebesar 42,53 K dan porositas terendah pada pendopingan nikel sebesar 20 persen berat yaitu sebesar 13,5% porositas.
Broadband-laser-diode pumped periodically poled potassium titanyl phosphate-Sagnac polarization-entangled photon source
Authors: Cai Neng , Cai Wu-Hao , Wang Shun , Li Fang , Shimizu Ryosuke , Jin Rui-Bo
Published: November 2021

We experimentally demonstrate a polarization-entangled photon source at 810 nm using a type-II phase-matched periodically poled potassium titanyl phosphate (PPKTP) crystal pumped by a low-cost, broadband laser diode with a central wavelength of 405 nm and a typical bandwidth of 0.53 nm. The PPKTP crystal is placed in a Sagnac loop to realize the compact size and high stability. The downconverted biphotons, the signal and the idler, have typical bandwidths of 5.57 and 7.32 nm. We prepare two Bell states

|

Ψ
+

⟩

and

|

Ψ
−

⟩

with the fidelities of

0.948

±

0.004

and

0.963

±

0.002

. In the polarization correlation measurement, the visibilities are all higher than 96.2%, and in the Bell inequality test, the

S

value can achieve

2.78

±

0.01

. This high-quality and low-cost entangled photon source may have many practical applications in quantum information processing.
Planar rainbow refractometry
Authors: Li Can , Lv Qimeng , Li Ning , Wu Yingchun , Wu Xuecheng , Weng Chunsheng , Tropea Cameron
Published: November 2021

Rainbow refractometry has been used in the past to measure size and refractive index of spherical particles, typically droplets in a spray. In the present study, conventional optical configurations for point measurements or line measurements have been extended to allow also the particle position in a plane to be determined, and hence, the designation planar rainbow refractometry. However, this extension introduces challenges in accurately calibrating the 2D scattering angles with the image coordinates. This challenge has been met using a novel calibration method, employing a monodispersed droplet stream traversed through the measurement plane. Experiments confirm achievable horizontal and vertical position accuracies of 0.42 mm and 0.36 mm, respectively, and a refractive index uncertainty of

2
×

10

−
4

.
Miniature non-contact photoacoustic probe based on fiber-optic photoacoustic remote sensing microscopy
Authors: Zhou Jiasheng , Zhou Jingying , Wang Wei , Liang Siqi , Jing Lili , Bo Shou-Hang , Chen Sung-Liang
Published: November 2021

Photoacoustic (PA) remote sensing (PARS) microscopy, featured by non-contact operation, has shown great potential for PA microscopy (PAM) imaging applications. However, current PARS microscopy systems are mainly based on free-space light, making the imaging head bulky and inconvenient to use. These issues hinder selected applications such as PA endoscopy and handheld PAM. Here, we report a miniature probe capable of non-contact PAM based on PARS microscopy. By utilizing fiber-optic components including a wavelength division multiplexer and an optical circulator, the imaging head can be highly miniaturized with a diameter of

∼

3.0

m
m

. Also, since all light is transmitted via fibers, the fiber-optic PARS microscopy system is relatively easy to build and facilitates scanning of the probe. In vivo imaging of a zebrafish larva and imaging of lithium metal batteries are conducted using the probe, showing its good imaging capability.
150 J DPSSL operating at 1.5 kW level
Authors: Divoký Martin , Pilař Jan , Hanuš Martin , Navrátil Petr , Denk Ondřej , Severová Patricie , Mason Paul , Butcher Thomas , Banerjee Saumyabrata , De Vido Mariastefania , Edwards Chris , Collier John , Smrž Martin , Mocek Tomas
Published: November 2021

We report on obtaining output energy of 146 J in 10 ns long pulses at 10 Hz repetition rate from Bivoj, a multi-Joule multi-slab cryogenic gas-cooled diode pumped solid state laser, by overcoming its damage threshold bottleneck. This is a 40% energy and power increase of the laser system in comparison to our previous publication and to the most powerful multi-Joule high power laser system.
Enabling VCSEL-on-silicon nitride photonic integrated circuits with micro-transfer-printing
Authors: Goyvaerts Jeroen , Grabowski Alexander , Gustavsson Johan , Kumari Sulakshna , Stassen Andim , Baets Roel , Larsson Anders , Roelkens Günther
Published: November 2021

New wavelength domains have become accessible for photonic integrated circuits (PICs) with the development of silicon nitride PICs. In particular, the visible and near-infrared wavelength range is of interest for a range of sensing and communication applications. The integration of energy-efficient III-V lasers, such as vertical-cavity surface-emitting lasers (VCSELs), is important for expanding the application portfolio of such PICs. However, most of the demonstrated integration approaches are not easily scalable towards low-cost and large-volume production. In this work, we demonstrate the micro-transfer-printing of bottom-emitting VCSELs on silicon nitride PICs as a path to achieve this. The demonstrated 850 nm lasers show waveguide-coupled powers exceeding 100 µW, with sub-mA lasing thresholds and mW-level power consumption. A single-mode laser with a side-mode suppression ratio over 45 dB and a tuning range of 5 nm is demonstrated. Combining micro-transfer-printing integration with the extended-cavity VCSEL design developed in this work provides the silicon nitride PIC industry with a great tool to integrate energy-efficient VCSELs onto silicon nitride PICs.
A gap-filling algorithm for prediction of metabolic interactions in microbial communities
Authors: Giannari Dafni , Ho Cleo Hanchen , Mahadevan Radhakrishnan
Published: November 2021

The study of microbial communities and their interactions has attracted the interest of the scientific community, because of their potential for applications in biotechnology, ecology and medicine. The complexity of interspecies interactions, which are key for the macroscopic behavior of microbial communities, cannot be studied easily experimentally. For this reason, the modeling of microbial communities has begun to leverage the knowledge of established constraint-based methods, which have long been used for studying and analyzing the microbial metabolism of individual species based on genome-scale metabolic reconstructions of microorganisms. A main problem of genome-scale metabolic reconstructions is that they usually contain metabolic gaps due to genome misannotations and unknown enzyme functions. This problem is traditionally solved by using gap-filling algorithms that add biochemical reactions from external databases to the metabolic reconstruction, in order to restore model growth. However, gap-filling algorithms could evolve by taking into account metabolic interactions among species that coexist in microbial communities. In this work, a gap-filling method that resolves metabolic gaps at the community level was developed. The efficacy of the algorithm was tested by analyzing its ability to resolve metabolic gaps on a synthetic community of auxotrophicEscherichia colistrains. Subsequently, the algorithm was applied to resolve metabolic gaps and predict metabolic interactions in a community ofBifidobacterium adolescentisandFaecalibacterium prausnitzii, two species present in the human gut microbiota, and in an experimentally studied community ofDehalobacterandBacteroidalesspecies of the ACT-3 community. The community gap-filling method can facilitate the improvement of metabolic models and the identification of metabolic interactions that are difficult to identify experimentally in microbial communities.
linus: Conveniently explore, share, and present large-scale biological trajectory data in a web browser
Authors: Waschke Johannes , Hlawitschka Mario , Anlas Kerim , Trivedi Vikas , Roeder Ingo , Huisken Jan , Scherf Nico
Published: November 2021

In biology, we are often confronted with information-rich, large-scale trajectory data, but exploring and communicating patterns in such data can be a cumbersome task. Ideally, the data should be wrapped with an interactive visualisation in one concise packet that makes it straightforward to create and test hypotheses collaboratively. To address these challenges, we have developed a tool, linus, which makes the process of exploring and sharing 3D trajectories as easy as browsing a website. We provide a python script that reads trajectory data, enriches them with additional features such as edge bundling or custom axes, and generates an interactive web-based visualisation that can be shared online. linus facilitates the collaborative discovery of patterns in complex trajectory data.
A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription
Authors: Bonnet Amandine , Chaput Carole , Palmic Noé , Palancade Benoit , Lesage Pascale
Published: November 2021

Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes (NPCs) regulate the expression of protein-coding genes. Here, we have implemented transcriptomic and molecular methods to specifically address the impact of the NPC on retroelements, which are present in multiple copies in genomes. We report a novel function for the Nup84 complex, a core NPC building block, in specifically restricting the transcription of LTR-retrotransposons in yeast. Nup84 complex-dependent repression impacts both Copia and Gypsy Ty LTR-retrotransposons, all over the S. cerevisiae genome. Mechanistically, the Nup84 complex restricts the transcription of Ty1, the most active yeast retrotransposon, through the tethering of the SUMO-deconjugating enzyme Ulp1 to NPCs. Strikingly, the modest accumulation of Ty1 RNAs caused by Nup84 complex loss-of-function is sufficient to trigger an important increase of Ty1 cDNA levels, resulting in massive Ty1 retrotransposition. Altogether, our study expands our understanding of the complex interactions between retrotransposons and the NPC, and highlights the importance for the cells to keep retrotransposons under tight transcriptional control.
Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish
Authors: Bühler Anja , Gahr Bernd M. , Park Deung-Dae , Bertozzi Alberto , Boos Alena , Dalvoy Mohankrishna , Pott Alexander , Oswald Franz , Kovall Rhett A. , Kühn Bernhard , Weidinger Gilbert , Rottbauer Wolfgang , Just Steffen
Published: November 2021

In contrast to mammals, the zebrafish maintains its cardiomyocyte proliferation capacity throughout adulthood. However, neither the molecular mechanisms that orchestrate the proliferation of cardiomyocytes during developmental heart growth nor in the context of regeneration in the adult are sufficiently defined yet. We identified in a forward genetic N-ethyl-N-nitrosourea (ENU) mutagenesis screen the recessive, embryonic-lethal zebrafish mutantbaldrian(bal), which shows severely impaired developmental heart growth due to diminished cardiomyocyte proliferation. By positional cloning, we identified a missense mutation in the zebrafishhistone deacetylase 1(hdac1) gene leading to severe protein instability and the loss of Hdac1 functionin vivo. Hdac1 inhibition significantly reduces cardiomyocyte proliferation, indicating a role of Hdac1 during developmental heart growth in zebrafish. To evaluate whether developmental and regenerative Hdac1-associated mechanisms of cardiomyocyte proliferation are conserved, we analyzed regenerative cardiomyocyte proliferation after Hdac1 inhibition at the wound border zone in cryoinjured adult zebrafish hearts and we found that Hdac1 is also essential to orchestrate regenerative cardiomyocyte proliferation in the adult vertebrate heart. In summary, our findings suggest an important and conserved role of Histone deacetylase 1 (Hdac1) in developmental and adult regenerative cardiomyocyte proliferation in the vertebrate heart.
A frequentist one-step model for a simple network meta-analysis of time-to-event data in presence of an effect modifier
Authors: Faron Matthieu , Blanchard Pierre , Ribassin-Majed Laureen , Pignon Jean-Pierre , Michiels Stefan , Le Teuff Gwénaël
Published: November 2021

Introduction

Individual patient data (IPD) present particular advantages in network meta-analysis (NMA) because interactions may lead an aggregated data (AD)-based model to wrong a treatment effect (TE) estimation. However, fewer works have been conducted for IPD with time-to-event contrary to binary outcomes. We aimed to develop a general frequentist one-step model for evaluating TE in the presence of interaction in a three-node NMA for time-to-event data.

Methods

One-step, frequentist, IPD-based Cox and Poisson generalized linear mixed models were proposed. We simulated a three-node network with or without a closed loop with (1) no interaction, (2) covariate-treatment interaction, and (3) covariate distribution heterogeneity and covariate-treatment interaction. These models were applied to the NMA (Meta-analyses of Chemotherapy in Head and Neck Cancer [MACH-NC] and Radiotherapy in Carcinomas of Head and Neck [MARCH]), which compared the addition of chemotherapy or modified radiotherapy (mRT) to loco-regional treatment with two direct comparisons. AD-based (contrast and meta-regression) models were used as reference.

Results

In the simulated study, no IPD models failed to converge. IPD-based models performed well in all scenarios and configurations with small bias. There were few variations across different scenarios. In contrast, AD-based models performed well when there were no interactions, but demonstrated some bias when interaction existed and a larger one when the modifier was not distributed evenly. While meta-regression performed better than contrast-based only, it demonstrated a large variability in estimated TE. In the real data example, Cox and Poisson IPD-based models gave similar estimations of the model parameters. Interaction decomposition permitted by IPD explained the ecological bias observed in the meta-regression.

Conclusion

The proposed general one-step frequentist Cox and Poisson models had small bias in the evaluation of a three-node network with interactions. They performed as well or better than AD-based models and should also be undertaken whenever possible.
Training the domestic ferret to discriminate odors associated with wildlife disease
Authors: Golden Glen J. , Opiekun Maryanne , Martin-Taylor Talia , Kimball Bruce A.
Published: November 2021

Recent avian influenza infection outbreaks have resulted in global biosecurity and economic concerns. Mallards are asymptomatic for the disease and can potentially spread AI along migratory bird flyways. In a previous study, trained mice correctly discriminated the health status of individual ducks on the basis of fecal odors when feces from post-infection periods were paired with feces from pre-infection periods. Chemical analyses indicated that avian influenza infection was associated with a marked increase of acetoin (3-hydroxy-2-butanone) in feces. In the current study, domesticated male ferrets (Mustela putorius furo) were trained to display a specific conditioned response (i.e. active scratch alert) in response to a marked increase of acetoin in a presentation of an acetoin:1-octen-3-ol solution. Ferrets rapidly generalized this learned response to the odor of irradiated feces from avian influenza infected mallards. These results suggest that a trained mammalian biosensor could be employed in an avian influenza surveillance program.
EDUARDO RIBEIRO AVENUE: Rescuing the past as a guide for the tourism in the city of Manaus-AM
Authors: Magabi Yara Araújo , Guimarães Márcia Raquel Cavalcante , Queroga Luciane da Silva
Published: November 2021

This study examines the historical, socio-cultural and tourist elements that are part of the composition of Eduardo Ribeiro Avenue, located in the city of Manaus-AM. Having as its general objective: to investigate how the Eduardo Ribeiro Avenue and the historical and tourist aspects that compose it, can be analysed in the context of heritage interpretation. Being its specific objectives: to identify the history of this avenue and its importance to the formation of cultural manauara's Â patrimony, raise the current elements that complete the landscape of the street and analyse its relationship with tourism and, suggests a touristic visitation route focused specifically for the Eduardo Ribeiro Avenue having as foundation the principles of patrimonial interpretation. A qualitative research with descriptive and exploratory objectives using bibliographical, documental and field technical procedures. Concerning the results, the Eduardo Ribeiro Avenue is considered the main artery of the centre of Manaus, this street has throughout its extension important historical buildings in addition to being one of the centres of commerce in the capital. The historicity is embodied in its urban layout, in its paving, in its cobblestones, in the century-old buildings that make it up along with its infrastructure, making the Avenue a very relevant space for tourist activity in the capital. Its relationship with tourism is based on the perspective of the rescue of a historical legacy for the manauara society and most importantly, the possibility of scripting the aforementioned avenue by the local tourist trade having as a foundation the principles of patrimonial interpretation.
Processo de alfabetização por meio das Literaturas Infantis / Literacy process through Children's Literatures
Authors: Emidio Lucilene , Oliveira Ivana Esteve Passos de
Published: November 2021

Resumo: A presente pesquisa tem sua origem nos desafios experimentados como professora de alfabetização e na tarefa de formar leitores, o que motivou a busca de soluções por meio de estudos e de investigações. Tendo como ideia, que a leitura é um processo um tanto complexo a ser desenvolvido e não pode ser reduzido à mera decodificação de textos, mas sim, levar os alunos a serem investigadores e letrados. Em face a essa constatação adveio o interesse em desenvolver uma prática de professora/mediadora/multiplicadora, envolvendo as estratégias de leitura com livros infantis de um autor capixaba, na premissa de suscitar a apreciação literária com os alunos, do nível 1 da Educação Infantil de uma escola particular de Vila Velha/ES, na qual a pesquisadora atua em sala de aula, como alfabetizadora. A metodologia utilizada no estudo, foi a da pesquisa-ação, contemplando as Oficinas de Estratégias de Leitura com a Literatura Infantil, direcionadas aos alunos mencionados, sob a tutela dessa investigadora, em que consolidou-se uma experiência significativa de letramento literário, explicitado no estudo de caso. Dentre os teóricos que nos embasaram, têm como destaque Coelho,2010, Souza ,2012, Junqueira, 2012, Solé, 1998 e Zilberman, 2003 e outros autores que refletem a literatura infantil, a compreensão e a autonomia leitora, resultando em fruição. Os resultados nas compreensão das estratégias proporcionaram formas que levaram os alunos a se tornarem leitores, nos ajudando no processo de alfabetização.
Uso de Metodologia Ativa no Ensino Remoto: Um Recurso para Melhorar o Aprendizado / The use of Active Methodologies in Remote Learning: A tool to improve Learning
Authors: Saraiva Piedley Macedo , Brito José Rogério Lima de , Torres Marcello De Barros Silva , Caffé Filho Hesler Piedade
Published: November 2021

Resumo: Com o surgimento da tecnologia educacional, as escolas adotaram métodos de ensino que divergem do ambiente típico de sala de aula. O ensino à distância está sendo usado em escala global e muitas instituições educacionais estão começando a implementar modelos de aprendizagem híbridos. Nesse sentido, essa pesquisa questionou quais os impactos do modelo de ensino híbrido no exercício das atividades do psicopedagogo. Diante disso, parte-se do pressuposto que o aprendizado híbrido é mais do que apenas colocar parte metade do currículo em uma sala de aula virtual. Este estudo tem como objetivo geral analisar verificar quais os impactos do modelo de ensino híbrido no exercício das atividades do psicopedagogo. Essa pesquisa se classifica como uma revisão de bibliográfica realizada de forma exploratória. Quanto a relevância acadêmica, esse estudo se faz justificável, visto que, a taxa de evasão escolar teve um crescimento no ano de 2021.Palavras-chave: Pscicopedago; Ensino online; Novas tendências. Abstract: With the rise of educational technologies, schools have adopted teaching methods that diverge from the typical classroom environment. Distance learning is being used on a global scale and many educational institutions are starting to implement hybrid learning models. In this sense, this research questioned the impacts of the hybrid teaching model in the exercise of the activities of the psychopedagogist. Therefore, it is assumed that hybrid learning is more than just putting half of the curriculum in a virtual classroom. This study aims to analyze the impact of the hybrid teaching model in the exercise of the activities of the psychopedagogist. This research is classified as a bibliographic review carried out in an exploratory manner. As for academic relevance, this study is justifiable, since the school dropout rate had an increase in the year 2021.Keywords:  Psychopedagogy. Online teaching. New tendencies.
Os Efeitos da Drenagem Linfática Manual no Pós-Cirúrgico da Abdominoplastia: Uma Revisão Integrativa da Literatura / The Effects of Manual Lymphatic Drainage in Post-Surgical Abdominoplasty: An Integrative Literature Review
Authors: Santos Isadora Chagas Correia , Santos Juliana Amorim Borba
Published: November 2021

Resumo: A drenagem linfática manual (DLM) realizada por massagem linfática, no pós-operatório de abdominoplastia com core lipoaspiração, pode promover resolução mais rápida do edema. Dessa forma, este presente estudo tem como objetivo demonstrar o efeito da drenagem linfática na abdominoplastia, expondo a importância do emprego da técnica no pós-operatório imediato para a diminuição de edemas. Trata-se de uma revisão integrativa, realizada através do levantamento nas bases de dados Lilacs, Scielo e Medline. A busca das publicações foi realizada no período de 2016 a 2021, através dos seguintes descritores: abdominoplastia, drenagem linfático e pós-operatório. Os estudos analisados acerca da temática proposta permitem inferir que a drenagem linfática manual auxilia na recuperação do pós-operatório da abdominoplastia mostrando ser uma área fundamentada em resultados concretos, onde se busca melhorar a aparência estética e a função, principalmente pela melhora da dor obtida com o tratamento. Palavras – Chave: Abdominoplastia, Drenagem linfática, Pós-operatório.  Abstract:  Manual lymphatic drainage (MLD) performed by lymphatic massage in the postoperative period of abdominoplasty with core liposuction can promote faster resolution of the edema. Thus, this present study aims to demonstrate the effect of lymphatic drainage in abdominoplasty, exposing the importance of using the technique in the immediate postoperative period to reduce edema. This is an integrative review, carried out through a survey in Lilacs, Scielo and Medline databases. The search for publications was carried out from 2016 to 2021, using the following descriptors: abdominoplasty, lymphatic drainage and postoperative period. The studies analyzed on the proposed theme allow us to infer that manual lymphatic drainage helps in the recovery of the postoperative period of abdominoplasty, showing that it is an area based on concrete results, where one seeks to improve the aesthetic appearance and function, mainly by improving the pain obtained with the treatment. Keywords: Abdominoplasty, Lymphatic drainage, Postoperative.
A Relevância da Família no Processo Educacional: Perspectivas e Desafios Segundo o Projeto Político Pedagógico da Escola Cleuzemi Pereira do Nascimento Silva / The Relevance of the Family in the Educational Process: Perspectives and Challenges According to the Political Pedagogical Project of the Cleuzemi Pereira do Nascimento Silva School
Authors: Costa Yara Silva da , Silva Marluce Iraneide Da , Santos Pedro Fernando Dos
Published: November 2021

Resumo: Esse trabalho tem por finalidade demostrar e analisar a importância da família no processo de aprendizagem do aluno, sendo assim, um dos principais motivos a serem alcançados é trazer a instituição família para esse ambiente escolar. O objetivo deste trabalho é compreender a construção do Projeto Político Pedagógico (PPP) em uma Gestão Democrática e Participativa. Visando ainda, destacar as práticas, valores e rotinas enfatizados no cotidiano escolar visando a realidade local que repercutem no espaço familiar. O estudo tem como base refletir a participação coletiva na construção do Projeto Político Pedagógico, entendido como a própria organização do trabalho pedagógico da escola como um todo. O trabalho desenvolvido é de natureza qualitativa com adição do campo, que se deu dentro das atividades do Programa de Residência Pedagógica, Além de adotar para a sua realização, teorias como as de Veiga (1994), Garcêz (2012), Polonia e Dessen (2005), Garcia (2006), a Lei de Diretrizes e Bases da Educação Nacional (LDBEN 9394/96) e leitura de artigos. Diante disso, foi possível compreender a importâncias da relação entre Família e Escola não somente na construção do PPP, mas também com alicerce na formação de cidadãos como meio de transformação no meio educacional.Palavras-Chave: Família; Escola; Relação; Aprendizagem; PPP. Abstract: This work aims to demonstrate and analyze the importance of the family in the student's learning process, thus, one of the main reasons to be achieved is to bring the family institution to this school environment. The objective of this work is to understand the construction of the Pedagogical Political Project (PPP) in a Democratic and Participatory Management. Also aiming to highlight the practices, values and routines emphasized in the daily school life, aiming at the local reality that affect the family space. The study is based on reflecting the collective participation in the construction of the Political Pedagogical Project, understood as the organization of the school's pedagogical work as a whole. The work developed is of a qualitative nature with the addition of the field, which took place within the activities of the Pedagogical Residency Program, in addition to adopting theories such as those of Veiga (1994), Garcêz (2012), Polonia and Dessen (2005), Garcia (2006), the Law of Guidelines and Bases of National Education (LDBEN 9394/96) and reading of articles. Therefore, it was possible to understand the importance of the relationship between Family and School not only in the construction of the PPP, but also based on the formation of citizens as a means of transformation in the educational environment.Keywords: Family; School; Relationship; Learning; PPP.
Prácticas escolares LGTBI+ inclusivas: Una mirada crítica al campo de investigaciones desde el Sur Global
Authors: Catalán-Marshall Mario
Published: November 2021

Este artículo plantea una interrogación crítica a las recientes investigaciones desarrolladas para la comprensión de la enseñanza de la diversidad sexual y de género en escuelas de Latinoamérica. Para ello se presenta una revisión de 16 artículos que investigaron sobre temáticas de inclusión LGTBI+ en las prácticas pedagógicas, la cultura escolar y la implementación curricular en el sistema escolar. Como principales hallazgos, se reconocen dos posturas epistemológicas en la construcción del conocimiento: una primera postura posestructuralista ligada a las teorizaciones queer en educación y una segunda postura híbrida o ecléctica ligada al campo de la sociología crítica de la educación. Ambas posturas evidencian una marcada influencia de las ideas basadas en las formulaciones de Michael Foucault y Judith Butler para comprender los fenómenos vinculados a la sexualidad y el género en el contexto educativo. De igual forma, se identificaron una serie de barreras de carácter discursivo que condicionan y enmarcan el desarrollo de la inclusión LGTBI+ en las escuelas, tales como currículos silenciadores, percepciones docentes de vigilancia parental e incipientes políticas educativas inclusivas de la diversidad sexual.