bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KUALITAS LAYANAN DAN KUALITAS PRODUK TERHADAP KEPUASAN NASABAH
Authors: Harini Kusumaning Ayu , Santoso Rohmad Prio
Published: October 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kuaalitas pelayanan dan kualitas produk terhadap kepuasan nasabah. Penelitian ini mengambil Obyek di BKAD Kec. Badas. Kab. Kediri. Penelitian ini menggunakan teknik Insidental Sampling terhadap  30 nasabah BKAD Kecamatan Badas Pare Kediri. Hasil penelitian menunjukkan (1) kualitas layanan  berpengaruh secara parsial terhadap kepuasan nasabah pada BKAD Kec. Badas Pare Kediri (2) Kualitas produk berpengaruh secara parsial terhadap kepuasan nasabah pada BKAD Kec. Badas pare Kediri (3) Kualitas layanan dan kualitas produk berpengaruh secara simultan dan signifikan kepada kepuasan dari nasabah pada BKAD  Kecamatan Badas Pare kediri
PENGARUH KUALITAS PELAYANAN DAN PROMOSI TERHADAP KEPUASAN PELANGGAN MARKETPLACE TIKTOK SHOP (STUDI KASUS PADA MAHASISWA MA’HAD JAMI’AH UNIVERSITAS HASYI ASY’ARI TEBUIRENG JOMBANG)
Authors: Maulitiana Ajeng Nurin , Aji Tony Seno
Published: October 2024

Penelitialn ini bertujualn untuk mengetalhui pengalruh kuallitals pelalyalnaln daln promosi terhaldalp kepualsaln pelalnggaln malrketplalce Tikto shop paldal malhalsiswal Mal’hald Jalmi’alh Universitals halsyim Alsy’alri Tebuireng Jombalng. Metode yalng digunalkaln paldal penelitialn ini yalitu metode penelitialn kualntitaltif daln menggunalkaln pendekaltaln kalusall altalu sebalb alkibalt. Populalsi dallalm penelitialn ini aldallalh 45 responden. Teknik pengalmbilaln salmpel aldallalh menggunalkaln teknik salmpel jenuh yalng menjaldikaln seluruh populalsi sebalgali salmpel, menggunalkaln metode regresi linier bergalndal. Halsil penelitialn menunjukkaln balhwal (1) Kuallitals pelalyalnaln (X1) secalral persiall berpengalruh positif daln signifikaln terhaldalp valrialbel Kepualsaln Pelalnggaln (Y) Malrketplalce Tiktok shop (2) Promosi (X2) secalral persiall berpengalruh positif daln signifikaln terhaldalp valrialbel Kepualsaln Pelalnggaln (Y) Malrketplalce Tiktok shop.
Studi Efisiensi Programmable Logic Controller Sebagai Kontroler Sensor Sistem Smart Home
Authors: Afianto Semeru , Adianto  , Imam Sutrisno
Published: October 2024

Penelitian ini bertujuan untuk mengevaluasi efisiensi penggunaan Programmable Logic Controller (PLC) sebagai pengendali sensor dalam lingkungan sistem rumah cerdas. Aspek-aspek yang dievaluasi mencakup kemampuan PLC dalam mengelola berbagai jenis sensor, keandalan dalam mengeksekusi program kontrol, serta fleksibilitas dalam melakukan modifikasi dan kustomisasi. Dalam studi ini, PLC Siemens S7-1200 digunakan bersama dengan sensor Proximity Induktif (PR12-4DP) untuk mendeteksi keberadaan objek logam dan sensor Photocell untuk mengatur pencahayaan otomatis. Hasil pengujian menunjukkan bahwa PLC Siemens S7-1200 mampu mengendalikan sensor dengan baik, meningkatkan efisiensi energi, kenyamanan penghuni, dan keamanan dalam lingkungan rumah cerdas. Penelitian ini memberikan wawasan berharga bagi pengembangan sistem rumah cerdas yang lebih efisien dan andal.
Implementasi Deteksi Kelengkapan APD pada Hazardous Area menggunakan Metode YoloV5
Authors: Ar Rahmah Nur Zafira Arya , Adianto  , Rini Indarti  , Zindhu Maulana Ahmad Putra  , Edy Setiawan  , Afif Zuhri Arfianto
Published: October 2024

Menurut data International Labour Organization, hampir 380.000 pekerja meninggal setiap tahunnya dan 374 juta pekerja mengalami cedera akibat kecelakaan kerja. Hazardous area adalah area berbahaya di industri yang mewajibkan penggunaan APD secara lengkap. Namun, seringkali pekerja kurang disiplin dalam penggunaan APD saat bekerja, yang dapat meningkatkan risiko kecelakaan kerja. Penelitian ini bertujuan untuk membuat sistem pendeteksian jenis APD yang digunakan pekerja pada hazardous area. metode yang digunakan penulis dalam penelitian ini yakni YOLOV5. Karena YOLOV5 mampu mendeteksi secara realtime dan lebih akurat dibadingkan dengan versi sebelumnya. Dataset yang digunakan 2600 gambar yang terbagi pada kelas lengkap, tidak lengkap, helm, kacamata masker, penutup telinga, sarung tangan, rompi, sepatu, tanpa helm, tanpa kacamata tanpa masker, tanpa penutup telinga, tanpa sarung tangan, tanpa rompi, tanpa sepatu, Pada penelitian ini, akurasi yang didapat dengan menggunakan metode YOLOV5 yang dihitung dengan persamaan yang ada dihasilkan 87%. Didapat nilai pressicion terhadap recall seluruh kelas sebesar 89%, recall terhadap confidence seluruh kelas ebesar 96%.
Implementasi Sistem Filtrasi Air Alami Terintegrasi Sensor TDS dan ESP32 Untuk Pemenuhan Baku Mutu Air Kelas
Authors: Lugas Jagad Satrianata  , Edy Setiawan  , Anda Iviana Juniani
Published: October 2024

Penelitian ini mengimplementasikan sistem filtrasi air alami untuk memenuhi standar baku mutu air kelas 3 sesuai PP No. 22/2021, dengan fokus pada Total Dissolved Solids (TDS). Sistem menggunakan bahan alami seperti karang jahe, ziolit, batu apung, oyster, bioball, dan bioring untuk menyaring kontaminan air. TDS dipantau secara real-time menggunakan sensor TDS yang terintegrasi dengan mikrokontroler ESP32. Pengujian pada sampel air kolam menunjukkan penurunan TDS dari 1619 ppm menjadi 443 ppm, di bawah batas maksimum 1000 ppm. Sensor TDS menunjukkan akurasi baik dengan error 1,94% untuk air kotor dan 10,38% untuk air bersih. Hasil ini menunjukkan potensi filtrasi air alami sebagai solusi efektif dan terjangkau untuk meningkatkan kualitas air. Penelitian lebih lanjut diperlukan untuk evaluasi jangka panjang dan parameter kualitas air lainnya.
Treatment and complications of PCOS in adolescents - what’s new in 2023?
Authors: Jakubowska-Kowal Karolina , Skrzyńska Karolina , Gawlik-Starzyk Aneta
Published: October 2024

Polycystic ovary syndrome (PCOS) is a disease affecting as many as about 10% of women of reproductive age, also 3-11% of teenage patients, and can lead to numerous complications and coexists with many diseases. Research is ongoing to establish an appropriate diagnostic and therapeutic path for adolescent girls with PCOS. It is also important to implement appropriate check-ups among teenagers with PCOS in order to prevent PCOS complications and initiate appropriate treatment as soon as possible and prevent the long-term consequences of these complications. The relationship between the co-occurrence of PCOS and diseases such as metabolic syndrome, hypertension, obesity, insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) is increasingly being investigated. A great attention is also being paid to the problem of mental health in this group of patients. In our study, we will review the latest reports on the treatment of PCOS and look at the complications that this syndrome can cause.
Role of complement factor D in cardiovascular and metabolic diseases
Authors: Kong Yingjin , Wang Naixin , Tong Zhonghua , Wang Dongni , Wang Penghe , Yang Qiannan , Yan Xiangyu , Song Weijun , Jin Zexi , Zhang Maomao
Published: October 2024

In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the alternative pathway. Abnormalities in CFD generation or function lead to aberrant immune responses and energy metabolism. A large number of studies have revealed that CFD is associated with CVMDs. Herein, we will review the current studies on the function and mechanism of CFD in CVMDs such as hypertension, coronary heart disease, ischemia/reperfusion injury, heart failure, arrhythmia, aortic aneurysm, obesity, insulin resistance, and diabetic cardiomyopathy.
Genetic variants of LRRC8C, OAS2, and CCL25 in the T cell exhaustion-related genes are associated with non-small cell lung cancer survival
Authors: Lu Guojun , Liu Hongliang , Wang Huilin , Tang Xiaozhun , Luo Sheng , Du Mulong , Christiani David C. , Wei Qingyi
Published: October 2024

Background

T cell exhaustion is a state in which T cells become dysfunctional and is associated with a decreased efficacy of immune checkpoint inhibitors. Lung cancer has the highest mortality among all cancers. However, the roles of genetic variants of the T cell exhaustion-related genes in the prognosis of non-small cell lung cancer (NSCLC) patients has not been reported.

Methods

We conducted a two-stage multivariable Cox proportional hazards regression analysis with two previous genome-wide association study (GWAS) datasets to explore associations between genetic variants in the T cell exhaustion-related genes and survival of NSCLC patients. We also performed expression quantitative trait loci analysis for functional validation of the identified variants.

Results

Of all the 52,103 single nucleotide polymorphisms (SNPs) in 672 T cell exhaustion-related genes, 1,721 SNPs were found to be associated with overall survival (OS) of 1185 NSCLC patients of the discovery GWAS dataset from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, and 125 of these 1,721 SNPs remained significant after validation in an additional independent replication GWAS dataset of 984 patients from the Harvard Lung Cancer Susceptibility (HLCS) Study. In multivariable stepwise Cox model analysis, three independent SNPs (i.e., LRRC8C rs10493829 T>C, OAS2 rs2239193 A>G, and CCL25 rs3136651 T>A) remained significantly associated with OS with hazards ratios (HRs) of 0.86 (95% confidence interval (CI) = 0.77-0.96, P = 0.008), 1.48 (95% CI = 1.18-1.85, P < 0.0001) and 0.78 (95% CI = 0.66-0.91, P = 0.002), respectively. Further combined analysis for these three SNPs suggested that an unfavorable genotype score was associated with a poor OS and disease-specific survival. Expression quantitative trait loci analysis suggested that the LRRC8C rs10493829 C allele was associated with elevated LRRC8C mRNA expression levels in normal lymphoblastoid cells, lung tissue, and whole blood.

Conclusion

Our findings suggested that these functional SNPs in the T cell exhaustion-related genes may be prognostic predictors for survival of NSCLC patients, possibly via a mechanism of modulating corresponding gene expression.
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma
Authors: Li Xinqiao , Xu Jingcheng , Li Xue , Shi Jianghua , Wei Chunmi , Liang Qingyu
Published: October 2024

Background

Hypoxic conditions in glioma are linked to tumor aggressiveness, poor prognosis, and treatment resistance. Long non-coding RNAs (lncRNAs) play key roles in the hypoxic and immune microenvironment of cancers, but their link to hypoxia-induced immunosuppression in high-grade glioma (HGG) is not well-studied.

Methods

Gene expression profiles from TCGA and CGGA, along with clinical and genomic data, were analyzed. Bioinformatics methods including Consensus Clustering, Pearson correlation, and Cox regression analyses were used. Cell proliferation was assessed using cell counting kit-8 and colony formation assays. Glioma-macrophage interactions were evaluated using a co-culture model.

Results

Hypoxia subtype clustering showed hypoxic stress correlates with worse HGG prognosis. Eight hypoxia-related lncRNAs (AP000695.4, OSMR-AS1, AC078883.3, RP11-545E17.3, LINC01057, LINC01503, TP73-AS1, and LINC00672) with prognostic value were identified, forming a risk signature that separated patients into distinct prognostic groups. Multivariate Cox regression confirmed the signature as an independent prognostic factor. High-risk patients had greater hypoxia, leading to an immunosuppressive environment and immunotherapy resistance via tumor-associated macrophages (TAMs). TP73-AS1 significantly influenced hypoxia-induced TAM infiltration and M2 polarization.

Conclusions

We profiled hypoxic stress in HGG and developed an 8-lncRNA hypoxia-related signature predicting patient survival and immunotherapy response, emphasizing its role in hypoxia-induced immunosuppression.
Evaluation of the stock enhancement effect of Phascolosoma esculenta on macrobenthic communities using diversity and biotic indices in Yueqing Bay, East China Sea
Authors: Yang Yushu , Song Chen , Chen Peng , Lu Wuyang , Han Qingxi
Published: October 2024

Stock enhancement activities have many benefits but also negative impacts. The macrobenthic diversity index and the M-AMBI index were adopted to assess the effects of stock enhancement of Phascolosoma esculenta on macrobenthic communities and the local ecosystem in Yueqing Bay. The results revealed that the Shannon–Wiener diversity index (H’) and Margalef richness index (d) increased in October 2022 after stock enhancement, indicating a positive ecological restoration effect. The average M-AMBI in the intertidal zone of Yueqing Bay was 0.59, indicating good benthic ecological quality. Excluding seasonal factors, the M-AMBI in the intertidal zone increased after stock enhancement, indicating that stock enhancement by Phascolosoma esculenta had a certain positive effect on the intertidal ecological environment of Yueqing Bay. The increase in the M-AMBI occurred mainly in the low-tide zone, increased slightly in the mid-tide zone, and remained basically unchanged in the high-tide zone. On the one hand, Phascolosoma esculenta can accumulate heavy metals from the environment and release a large amount of organic matter throughout its lifecycle, promoting nutrient cycling, which plays a positive role in the environment. On the other hand, Phascolosoma esculenta is an economic species; however, the planting of mangroves in the low tide zone causes fishers to fish in the mid- and high-tide zones, so the changes in the M-AMBI values in each tidal zone are related mainly to Phascolosoma esculenta and anthropogenic disturbances.
Chebulinic acid isolated from aqueous extracts of Terminalia chebula Retz inhibits Helicobacter pylori infection by potential binding to Cag A protein and regulating adhesion
Authors: Ou Ling , Hao Yajie , Liu Hengrui , Zhu Zhixiang , Li Qingwei , Chen Qingchang , Wei Ruixia , Feng Zhong , Zhang Guimin , Yao Meicun
Published: October 2024

Background

Terminalia chebula Retz, known as the King of Tibet, is considered a functional food in China, celebrated for its antioxidant, immune-modulating, antibacterial, and anti-inflammatory properties. Chebulinic acid, derived from aqueous extracts of Terminalia chebula Retz, is known for its anti-inflammatory properties. However, its potential as an anti-Helicobacter pylori (HP) agent has not been fully explored.

Methods

Herein, we extracted the main compound from Terminalia chebula Retz using a semi-preparative liquid chromatography (LC) system and identified compound 5 as chebulinic acid through Ultra-high performance liquid chromatography-MS/MS (UPLC–MS/MS) and Nuclear Magnetic Resonance (NMR). To evaluate its role, we conducted minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays, scanning electron microscope (SEM) imaging, inhibiting kinetics curves, urea fast test, cell counting kit-8 (CCK-8) assay, western blot analysis, griess reagent system, and molecular docking.

Results

Our results showed that chebulinic acid effectively inhibited the growth of the HP strain ATCC 700392, damaged the HP structure, and exhibited selective antimicrobial activity without affecting normal epithelial cells GES-1. Importantly, it suppressed the expression of Cytotoxin-associated gene A (Cag A) protein, a crucial factor in HP infection. Molecular docking analysis predicted a strong affinity (−9.7 kcal/mol) between chebulinic acid and Cag A protein.

Conclusion

Overall, our findings suggest that chebulinic acid acts as an anti-adhesive agent, disrupting the adhesion of HP to host cells, which is a critical step in HP infection. It also suppresses the Cag A protein. These results highlight the potential of chebulinic acid against HP infections.
Circulating levels of micronutrients and risk of osteomyelitis: a Mendelian randomization study
Authors: Zhang Xu , Wang Jiaxing , Wu Zhimeng , Xin Binglong , He Shuixiang , He Zitong , Li Yarui
Published: October 2024

Background

Few observational studies have investigated the effect of micronutrients on osteomyelitis, and these findings are limited by confounding and conflicting results. Therefore, we conducted Mendelian randomization (MR) analyses to evaluate the association between blood levels of eight micronutrients (copper, selenium, zinc, vitamin B12, vitamin C, and vitamin D, vitamin B6, vitamin E) and the risk of osteomyelitis.

Methods

We performed the two-sample and multivariable Mendelian randomization (MVMR) to investigate causation, where instrument variables for the predictor (micronutrients) were derived from the summary data of micronutrients from independent cohorts of European ancestry. The outcome instrumental variables were used from the summary data of European-ancestry individuals (n = 486,484). The threshold of statistical significance was set at p < 0.00625.

Results

We found a significant causal association that elevated zinc heightens the risk of developing osteomyelitis in European ancestry individuals OR = 1.23 [95% confidence interval (CI) [1.07, 1.43]; p = 4.26E-03]. Similarly, vitamin B6 showed a similar significant causal effect on osteomyelitis as a risk factor OR = 2.78 (95% CI [1.34, 5.76]; p = 6.04E-03; in the secondary analysis). Post-hoc analysis suggested this result (vitamin B6). However, the multivariable Mendelian randomization (MVMR) provides evidence against the causal association between zinc and osteomyelitis OR = 0.98(95% CI [−0.11, 0.07]; p = 7.20E-1). After searching in PhenoScanner, no SNP with confounding factors was found in the analysis of vitamin B6. There was no evidence of a reverse causal impact of osteomyelitis on zinc and vitamin B6.

Conclusion

This study supported a strong causal association between vitamin B6 and osteomyelitis while reporting a dubious causal association between zinc and osteomyelitis.
Spatiotemporal delivery of multiple components of rhubarb-astragalus formula for the sysnergistic treatment of renal fibrosis
Authors: Zhang Qibin , Ye Xiaofeng , Zhu Lin , Xu Zhishi , Hou Yu , Ke Qiaoying , Feng Jiawei , Xie Xiaowei , Chen Danfei , Piao Ji-Gang , Wei Yinghui
Published: October 2024

Purpose

Rhubarb (Rheum palmatum L.) and astragalus (Radix astragali) find widespread used in clinical formulations for treating chronic kidney disease (CKD). Notably, the key active components, total rhubarb anthraquinone (TRA) and total astragalus saponin (TAS), exhibit superiority over rhubarb and astragalus in terms of their clear composition, stability, quality control, small dosage, and efficacy for disease treatment. Additionally, astragalus polysaccharides (APS) significantly contribute to the treatment of renal fibrosis by modulating the gut microbiota. However, due to differences in the biopharmaceutical properties of these components, achieving synergistic effects remains challenging. This study aims to develop combined pellets (CPs) and evaluate the potential effect on unilateral ureteral obstruction (UUO)-induced renal fibrosis.

Methods

The CPs pellets were obtained by combining TRA/TAS-loaded SNEDDS pellets and APS-loaded pellets, prepared using the fluidized bed coating process. The prepared pellets underwent evaluation for morphology, bulk density, hardness, and flowing property. Moreover, the in vitro release of the payloads was evaluated with the CHP Type I method. Furthermore, the unilateral ureteral obstruction (UUO) model was utilized to investigate the potential effects of CPs pellets on renal fibrosis and their contribution to gut microbiota modulation.

Results

The ex-vivo study demonstrated that the developed CPs pellets not only improved the dissolution of TRA and TAS but also delivered TRA/TAS and APS spatiotemporally to the appropriate site along the gastrointestinal tract. In an animal model of renal fibrosis (UUO rats), oral administration of the CPs ameliorated kidney histological pathology, reduced collagen deposition, and decreased the levels of inflammatory cytokines. The CPs also restored the disturbed gut microbiota induced by UUO surgery and protected the intestinal barrier.

Conclusion

The developed CPs pellets represent a promising strategy for efficiently delivering active components in traditional Chinese medicine formulas, offering an effective approach for treating CKD.
Optimizing nitrogen fertilization in maize: the impact of nitrification inhibitors, phosphorus application, and microbial interactions on enhancing nutrient efficiency and crop performance
Authors: Malakshahi Kurdestani Ali , Francioli Davide , Ruser Reiner , Piccolo Alessandro , Maywald Niels Julian , Chen Xinping , Müller Torsten
Published: October 2024

Despite the essential role of nitrogen fertilizers in achieving high crop yields, current application practices often exhibit low efficiency. Optimizing nitrogen (N) fertilization in agriculture is, therefore, critical for enhancing crop productivity while ensuring sustainable food production. This study investigates the effects of nitrification inhibitors (Nis) such as Dimethyl Pyrazole Phosphate (DMPP) and Dimethyl Pyrazole Fulvic Acid (DMPFA), plant growth-promoting bacteria inoculation, and phosphorus (P) application on the soil-plant-microbe system in maize. DMPFA is an organic nitrification inhibitor that combines DMP and fulvic acid for the benefits of both compounds as a chelator. A comprehensive rhizobox experiment was conducted, employing varying levels of P, inoculant types, and Nis, to analyze the influence of these factors on various soil properties, maize fitness, and phenotypic traits, including root architecture and exudate profile. Additionally, the experiment examined the effects of treatments on the bacterial and fungal communities within the rhizosphere and maize roots. Our results showed that the use of Nis improved plant nutrition and biomass. For example, the use of DMPFA as a nitrification inhibitor significantly improved phosphorus use efficiency by up to 29%, increased P content to 37%, and raised P concentration in the shoot by 26%, compared to traditional ammonium treatments. The microbial communities inhabiting maize rhizosphere and roots were also highly influenced by the different treatments. Among them, the N treatment was the major driver in shaping bacterial and fungal communities in both plant compartments. Notably, Nis reduced significantly the abundance of bacterial groups involved in the nitrification process. Moreover, we observed that each experimental treatment employed in this investigation could select, promote, or reduce specific groups of beneficial or detrimental soil microorganisms. Overall, our results highlight the intricate interplay between soil amendments, microbial communities, and plant nutrient dynamics, suggesting that Nis, particularly DMPFA, could be pivotal in bolstering agricultural sustainability by optimizing nutrient utilization.
Predicting implementation of response to intervention in math using elastic net logistic regression
Authors: Wang Qi , Hall Garret J. , Zhang Qian , Comella Sara
Published: October 2024

Introduction

The primary objective of this study was to identify variables that significantly influence the implementation of math Response to Intervention (RTI) at the school level, utilizing the ECLS-K: 2011 dataset.

Methods

Due to missing values in the original dataset, a Random Forest algorithm was employed for data imputation, generating a total of 10 imputed datasets. Elastic net logistic regression, combined with nested cross-validation, was applied to each imputed dataset, potentially resulting in 10 models with different variables. Variables for the models derived from the imputed datasets were selected using four methods, leading to four candidate models for final selection. These models were assessed based on their performance of prediction accuracy, culminating in the selection of the final model that outperformed the others.

Results and discussion

Method50 and Methodcoef emerged as the most effective, achieving a balanced accuracy of 0.852. The ultimate model selected relevant variables that effectively predicted RTI. The predictive accuracy of the final model was also demonstrated by the receiver operating characteristic (ROC) plot and the corresponding area under the curve (AUC) value, indicating its ability to accurately forecast math RTI implementation in schools for the following year.
Shaping infants’ social brains through vicarious social learning: the importance of positive mother–father interactions
Authors: Rousseau Sofie , Avital Nuphar , Tolpyhina Yuliya
Published: October 2024

Introduction

This study is the first to assess whether infants’ developing social brains may be susceptible to the vicarious social experience of interparental positivity. Specifically, we explored whether infants’ exposure to interparental positivity may vicariously shape their neural substrates of social development.

Methods

In a sample of 45 infants (MAgeMonths = 11.01; 48.9% girls), infant left-frontal resting alpha electroencephalogram (EEG) asymmetry was derived as a reliable indicator of neural substrates linked to adaptive social development. Moreover, positive characteristics of the mother–father couple relationship were assessed both by means of observation and self-report by mother and father. Importantly, various relevant covariates were considered, including interparental negativity (observed and self-reported), as well as infants’ direct caregiving experiences and duration of infant exposure to mother–father relationship-dynamics (parent-report).

Results

Results indicated that higher levels of observed interparental positivity were associated with greater infant left-frontal alpha EEG asymmetry, even after accounting for covariates (β’s > 0.422).

Discussion

The current study’s results are first to suggest that positive vicarious social experiences in infants’ day-to-day lives play a significant role for early neural development.
Association between sleep disturbances and suicidal behavior in adolescents: a systematic review and meta-analysis
Authors: Baldini Valentina , Gnazzo Martina , Rapelli Giada , Marchi Mattia , Pingani Luca , Ferrari Silvia , De Ronchi Diana , Varallo Giorgia , Starace Fabrizio , Franceschini Christian , Musetti Alessandro , Poletti Michele , Ostuzzi Giovanni , Pizza Fabio , Galeazzi Gian Maria , Plazzi Giuseppe
Published: October 2024

Introduction

Adolescents’ health and well-being are seriously threatened by suicidal behaviors, which have become a severe social issue worldwide. Suicide is one of the leading causes of mortality for adolescents in low and middle-income countries, with approximately 67,000 teenagers committing suicide yearly. Although an association between sleep disturbances (SDs) and suicidal behaviors has been suggested, data are still scattered and inconclusive. Therefore, to further investigate this association, we conducted a meta-analysis to verify if there is a link between SDs and suicidal behaviors in adolescents without diagnosed psychiatric disorders.

Methods

PubMed, CENTRAL, EMBASE, and PsycINFO were searched from inception to August 30th, 2024. We included studies reporting the estimation of suicidal behaviors in adolescents from 12 to 21 years of age, with SDs and healthy controls. The meta-analysis was based on odds ratio (OR, with a 95% confidence interval ([CI]), estimates through inverse variance models with random-effects.

Results

The final selection consisted of 19 eligible studies from 9 countries, corresponding to 628,525 adolescents with SDs and 567,746 controls. We found that adolescents with SDs are more likely to attempt suicide (OR: 3.10; [95% CI: 2.43; 3.95]) and experience suicidal ideation (OR: 2.28; [95% CI 1.76; 2.94]) than controls.

Conclusion

This meta-analysis suggests that SDs are an important risk factor for suicidal ideation and suicide attempts in healthy adolescents. The findings highlight the importance of early identification of SDs to prevent suicidal behaviors in this population.

Systematic review registration

PROSPERO, identifier CRD42023415526.
Developing a rapid predictive model for falls in older hospitalized patients
Authors: Hu Mengmeng , Lu Sujuan , Guan Jiangan , Deng Wenqian , Hu Yu , Huang Yao , Li Keying , He Mengdan , Wang Zhiyi , Chen Chan , Chen Xiufang
Published: October 2024

Background

This study was aimed to identify the independent risk factors for falls n hospitalized older patients and develop a corresponding predictive model.

Methods

A retrospective observational study design was adopted, comprising 440 older patients with falls history and 510 older patients without falls history during hospitalization. Data collected included demographic information, vital signs, comorbidities, psychiatric disorder, function absent, current medication, other clinical indicators.

Results

Mobility disability, high-risk medications use, frequency of hospitalizations, psychiatric disorder, visual impairment are independent risk factors for falls in older patients. The A-M2-HPV scoring system was developed. The AUC value of the nomogram was 0.884, indicating the model has excellent discriminative ability. The AUC value of the A-M2-HPV score was 0.788, demonstrating better discrimination and stratification capabilities.

Conclusion

The A-M2-HPV scoring system provides a valuable tool to assess the risk of falls in hospitalized older patients and to aid in the implementation of preventive measures.
Women’s knowledge, attitude, and practice regarding cervical precancerous lesions: a cross-sectional study in Beijing, China
Authors: Wang Lingyan , Wang Qianping , Zhou Xia , Liu Huan
Published: October 2024

Background

This study aimed to examine the knowledge, attitude, and practice (KAP) of women in Beijing regarding cervical precancerous lesions.

Methods

This web-based, cross-sectional study included women at Dongzhimen Hospital of Beijing University of Chinese Medicine between March 13, 2024 and April 9, 2024. A self-administered questionnaire was developed to collect participants’ demographic information and KAP scores toward cervical precancerous lesions.

Results

The study included 951 valid questionnaires, with a mean age of 40.0 years. The mean knowledge, attitude, and practice scores were 12.55 ± 6.23 (possible range: 0–26), 50.66 ± 7.48 (possible range: 13–65), and 26.13 ± 4.98 (possible range: 7–35), respectively. The knowledge score (OR = 1.071, 95%CI: 1.040–1.103, p < 0.001), currently married (OR = 0.548, 95%CI: 0.304–0.985, p = 0.045), and with a history of HPV infection (OR = 2.302, 95%CI: 1.062–4.990, p = 0.035) were independently associated with the attitude score. The knowledge score (OR = 1.155, 95%CI: 1.119–1.192, p < 0.001), monthly income >20,000 (OR = 2.793, 95%CI: 1.249–6.248, p = 0.012), a history of HPV infection (OR = 0.380, 95%CI: 0.222–0.650, p < 0.001), unknown HPV infection status (OR = 0.289, OR = 0.177–0.473, p < 0.001), vaccinated against HPV (OR = 1.752, 95%CI: 1.221–2.514, p = 0.002), giving birth to one child (OR = 1.991, 95%CI: 1.186–3.341, p = 0.009), and giving birth to two or more children (OR = 2.160, 95%CI: 1.240–3.763, p = 0.007) were independently associated with the practice score. The structured equation model showed that knowledge directly influenced attitude (β = 0.237, p = 0.004) and practice (β = 0.490, p = 0.010). Attitude directly influenced practice (β = 0.193, p = 0.009).

Conclusion

This study revealed inadequate knowledge, moderate attitude, and practice toward cervical precancerous lesions among women in Beijing. Educational interventions should be developed to enhance knowledge in this regard.
Ethylene oxide exposure, inflammatory indicators, and depressive symptoms: a cross-sectional study and mediation analysis based on a non-institutionalized American population
Authors: Du Dongru , Yuan Yanling , Guan Xuan , Xie Qinglian , Dong Zaiquan
Published: October 2024

Background

Ethylene oxide (EO) is a volatile compound positively correlated with respiratory and cardiovascular diseases. Currently, evidence suggests that environmental exposure may contribute to depressive symptoms. This study evaluated the correlation between EO exposure and depressive symptoms and investigated whether inflammatory indicators had a mediation effect on this correlation.

Methods

Patients were enrolled from the National Health and Nutrition Examination Survey during 2013–2016, and 2,764 (49.67% male and 50.33% female) participants were ultimately included. EO exposure was determined by measuring hemoglobin-EO adduct (Hb-EO) concentration due to its long half-life, which was log2-transformed. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Multivariable logistic regression analysis was performed to identify any correlations before and after covariate adjustment. Sensitivity analysis, subgroup analyses, and interaction tests were performed to further evaluate identified correlations. Mediation analysis was conducted to reveal whether specific inflammatory indicators mediated the correlation.

Results

A high prevalence of depressive symptoms was observed in quartiles with increased levels of EO exposure, and male individuals exhibiting higher Hb-EO levels than female individuals. A positive correlation was observed between EO exposure and depressive symptoms (odds ratio [OR]: 1.439, 95% confidence interval [CI]: 1.310, 1.581), which remained stable even after covariate adjustment (OR: 1.332, 95% CI: 1.148, 1.545). Interaction tests showed significant effects of sex (p < 0.001) and thyroid diseases (p = 0.048) on this correlation. In the mediation analysis, white blood cell (p = 0.010) and neutrophil counts (p = 0.010) exerted a mediating effect, accounting for 13.6 and 11.9%, respectively.

Conclusion

Increased exposure to EO is associated with an elevated risk of depressive symptoms, where white blood cell and neutrophil counts exert a significant mediating effect. Further prospective studies are required to investigate the potential link among EO, other environmental pollutants, and human mental health.
Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats
Authors: Ai Jing , Gao Yunfeng , Yang Fan , Zhao Zhen , Dong Jin , Wang Jing , Fu Shiyi , Ma Ying , Gu Xu
Published: October 2024

Physiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats. The goal was to predict the distribution of the drug after multiple oral administrations. The preliminary PBPK model for RAC in goats performed well in predicting the drug’s distribution in most tissues. In our sensitivity analysis, we found that the parameter of Qclu (Blood Flow Volume through Lungs) had the greatest impact on the RAC concentrations in plasma, liver, and kidney and was the most sensitive parameter. Furthermore, our study aimed to assess the withdrawal time (WT) of RAC in different tissues after RAC long-term exposure in goats. We found that the WT of RAC in the kidney was the longest, lasting for 13  days. Overall, the insights gained from this study have important implications for optimizing drug administration in goats and ensuring appropriate withdrawal times to prevent any potential risks.
Robust H-Infinity Dual Cascade MPC-Based Attitude Control Study of a Quadcopter UAV
Authors: Hui Nanmu , Guo Yunqian , Han Xiaowei , Wu Baoju
Published: October 2024

Aimed at the stability problem of quadrotor Unmanned Aerial Vehicle (UAV) flight attitudes under random airflow disturbance conditions, a robust H-infinity-based dual cascade Model Predictive Control (MPC) attitude control method is proposed. Model Predictive Control itself has the capability to minimize the deviation between the prediction error and the control target by optimizing the control algorithm. The robust H-infinity controller can maintain stability in the face of system model uncertainty and external disturbances. The controller designed in this paper divides the attitude control loop into the following two parts: the angle loop and the angular velocity loop. The angle loop, serving as the main control loop of the attitude control, employs the robust H-infinity controller to process the angle of the quadrotor UAV and then transmits the processed value to the MPC controller. This approach reduces the computational load of the MPC controller. Simultaneously, by optimizing the algorithm, MPC minimizes the prediction error and the deviation from the control target. Simulation experiments confirm that the proposed algorithm improves the stability of the UAV attitude under random airflow disturbance conditions, while also achieving accurate tracking of the UAV’s position.
Comparative Evaluation of the Phytochemical Composition of Fruits of Ten Haskap Berry (Lonicera caerulea var. kamtschatica Sevast.) Cultivars Grown in Poland
Authors: Żurek Natalia , Pluta Stanisław , Seliga Łukasz , Lachowicz-Wiśniewska Sabina , Kapusta Ireneusz Tomasz
Published: October 2024

The aim of this study was to investigate the qualitative and quantitative fruit profiles of ten cultivars (cvs.) of haskap berry (Lonicera caerulea var. kamtschatica Sevast.) to determine their antioxidant activity (ABTS test, CUPRAC test, ability to capture superoxide (O2˙−) and hydroxyl radicals (OH˙)), cytotoxic activity (against cancer cell lines breast, MCF-7; colon, HT-29; and melanoma, SK-Mel-28) and physicochemical properties. Most of the selected cultivars had not previously been analyzed for these properties. A total of 19 polyphenolic compounds were identified in the fruits of the tested genotypes, with a quantitative range of 2166.3–3597.0 µg/g. The polyphenol profile was dominated by anthocyanins (90.0–92.4%), and the remaining classes occurred in the following order: phenolic acids > flavonols > flavan-3-ols. The highest concentrations of these polyphenol groups were found in the cultivars ‘Honeybee’, ‘Sinij Uties’ and ‘Usłada’. The fruits of these cultivars were also characterized by the highest antioxidant activity (546.6–683.5 µg/mL for O2˙− and 541.2–652.1 µg/mL for OH˙) and cytotoxic activity (103.6–649.2 µg/mL). The data obtained indicate that the fruits of the new haskap cultivars are a good source of bioactive compounds with possible health-promoting properties.
Investigation of Impact Contact Force Testing and Damage Analysis on Potatoes
Authors: Zhao Zexin , Deng Weigang , Hu Xin , Yu Haohe , Li Qiying
Published: October 2024

To investigate the influencing factors and intrinsic relationships between potato impact force and impact damage during potato soil separation, a testing system for potato impact force was established. The impact force test system is composed of a base, a height adjustment device, a simple separation screen, a soil storage tank, an impact force sensor, and so on. By allowing potatoes to fall freely to simulate the collision process, impact force data are collected, and a high-speed camera is used to locate the impact position and analyze the degree of damage. Through the response surface analysis method, the influencing factors and laws of the impact force and impact damage during the collision process between potatoes and rods under soil and no-soil conditions were studied. The results of the response surface analysis indicate that when the screen inclination is within the range of 14.12° to 14.77°, falling height ranges from 453.83 mm to 500 mm, screen rod spacing falls within 36.50 mm to 40 mm, and the screen rod material is rubber. Potatoes can still be at a relatively low damage level when enduring a large impact force. This study has significant implications for reducing potato impact damage during harvesting, enhancing economic benefits in the potato industry, and advancing the technical level of potato harvesting equipment. In the future, based on the results of this study, further exploration can be made to optimize the design of potato harvesting equipment so as to better reduce the damage to potatoes during harvesting and subsequent processing processes and promote the sustainable development of the potato industry.
Design and Testing of an Electric Side-Mounted Cabbage Harvester
Authors: Liu Ze , Wang Enguang , Mao Hanping , Zuo Zhiyu , Peng Haitao , Zhao Mingxue , Yu Yongsheng , Li Zhikang
Published: October 2024

To address the limitations of current cabbage harvesters in China, which are often designed for a single variety and lack adaptability to different cabbage varieties, we developed an electric side-mounted cabbage harvester suitable for field operations in the Jiangsu region of China. This design is informed by the statistical analysis of the physical and agronomic parameters of major cabbage varieties. The harvester consists of key components, including an extraction device, a leaf-stripping device, a clamping and conveying device, and a root-cutting device. Powered by a 120 Ah direct current (DC) power source, it is capable of performing cabbage extraction, feeding, clamping, conveying, root cutting, and boxing in a single operation for three hours. Through theoretical analysis of the key components, specific parameters were determined, and field tests were conducted to verify the design. The results of the field experiments indicate that all components of the cabbage harvester operated effectively. Optimal performance was observed when the extraction roller speed was set between 100 and 110 RPM, the conveyor belt speed at 60 RPM, and the cutter speed between 160 and 220 RPM, resulting in a low cabbage harvest loss rate. The harvest loss rates from the three experiments were 11.3%, 13.3%, and 12%, respectively, which meets the mechanical harvesting requirements for cabbage.
Unveiling the Effects of Phosphorus on the Mineral Nutrient Content and Quality of Alfalfa (Medicago sativa L.) in Acidic Soils
Authors: Li Zhou , Hao Yunfei , Wang Xiaowen , He Jin , Zhao Xuechun , Chen Jihui , Gu Xinyao , Zhang Mingjun , Yang Feng , Dong Rui
Published: October 2024

Alfalfa (Medicago sativa L.) grown in acidic soils is often affected by phosphorus (P) deficiency, which results in reduced mineral nutrient content and forage quality. In this context, the effects of phosphorus (P) fertiliser remain unclear. In this study, we analysed the effects of P application on mineral nutrient content and forage quality in aluminium (Al)-sensitive (Longzhong) and Al-tolerant (Trifecta) alfalfa cultivars cultivated in two acidic soil environments. Mineral nutrient content and quality were affected by genotype, soil type, and P treatment concentration (p < 0.001). In limestone soil, for Longzhong and Trifecta, the optimal potassium (K), calcium (Ca), and magnesium (Mg) contents as well as crude protein content (CP) and ether extract (EE) values were observed at 20 mg P kg−1, that of the P content was observed at 40 mg P kg−1, and the minimum neutral detergent fibre (NDF) acid detergent lignin (ADL) values were observed at 40 mg P kg−1. In yellow soil, the maximum K, Ca, Mg, and P contents in Longzhong and Trifecta were observed at 40 mg P kg−1, whereas the maximum CP, EE, and ADL values were observed at 20 mg P kg−1. Our study provides an empirically based framework for optimising alfalfa fertilisation programmes in acidic soils.
Tomato Pedicel Physical Characterization for Fruit-Pedicel Separation Tomato Harvesting Robot
Authors: Weng Wuxiong , He Minglei , Zheng Zebin , Lin Tianliang , Lai Zhenhui , Zheng Shuhe , Wu Xinhui
Published: October 2024

To solve the problem of the lack of physical properties of pedicels and the changing pattern for designing the end-effector of tomato harvesting robot and different harvesting modes, research was conducted on the physical properties of tomato pedicels and their change patterns. Using a Universal TA texture analyzer, tensile, three-point bending, and shearing tests were performed on tomato pedicels in the early firm-ripening stage. The tomato variety used was Syngenta Spectrum, cultivated seasonally with two crops per year. Spring crop tomatoes were used in this study. The experimental results provide a theoretical basis for designing tomato harvesting robots across three harvesting modes. Tensile tests measured the pull-off force and tensile strength of the abscission zone with varying diameters. These results are crucial for designing robots using a tensile harvesting mode. The location of the tomato pedicel significantly affects the shearing force. A one-way test was conducted on the shearing part. The results showed that the shearing force and energy required for the proximal pedicel are significantly greater than for the distal pedicel. To reduce the shearing force and energy needed by the end-effector’s shearing mechanism on distal pedicels, a response surface test was conducted. Three factors were examined: shearing speed, angle, and distal pedicel diameter. Design–Expert software optimized these factors to minimize shearing energy and force, leading to the best shearing parameters for different distal pedicel diameters. From the three-point bending tests, the average maximum bending breaking force, bending modulus, and bending strength of the tomato abscission zone were determined. These findings offer a theoretical basis for designing tomato harvesting robots with a bending-type harvesting mode.
Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-Producing Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. Isolated from Humans and the Kitchen Environment of Two Greek Hospitals
Authors: Tsitsos Anestis , Damianos Alexandros , Boutel Maria , Gousia Panagiota , Soultos Nikolaos , Papa Anna , Tirodimos Ilias , Economou Vangelis
Published: October 2024

Background: Extended-spectrum-β-lactamase (ESBL) and carbapenemase-producing Enterobacterales and Acinetobacter spp. pose significant challenges as nosocomial pathogens, demonstrating resistance against various antimicrobials. Their presence in food suggests that hospital kitchens could serve as antibiotic resistance reservoirs leading to patients’ infection. Objectives: The aim of this study was to assess the prevalence and characteristics of β-lactam-resistant strains of Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. isolated from the kitchen environment and from the staff of two Greek hospitals. Methods: Strains were recovered after selective isolation with β-lactams and were identified with MALDI–TOF MS. Antimicrobial susceptibility and presence of common β-lactamase genes were evaluated. Protein profiles were examined to analyze potential relationships of the strain with those from hospital patients. E. coli strains were further categorized into phylogenetic groups. Results: The overall prevalence in the kitchen environment was 4.5%, 1.5%, and 15.0% for E. coli, K. pneumoniae, and Acinetobacter spp., respectively, whereas the prevalence of Acinetobacter spp. in human skin was 4.0%. Almost all strains were multidrug-resistant. All E. coli strains were ESBL producers and belonged to phylogroups A and B1. All K. pneumoniae and seven Acinetobacter strains were carbapenemase-producers. A protein profile analysis showed relatedness between chicken and kitchen environment strains, as well as between kitchen environment and patient strains originated either from the same or from different hospitals. Conclusions: The results suggest that hospital kitchens may act as important pathogen hotspots contributing to the circulation of resistant strains in the hospital environment.