bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Remote Sensing, GIS and Machine Learning with Geographically Weighted Regression in Assessing the Impact of Hard Coal Mining on the Natural Environment
Authors: Kopeć Anna , Trybała Paweł , Głąbicki Dariusz , Buczyńska Anna , Owczarz Karolina , Bugajska Natalia , Kozińska Patrycja , Chojwa Monika , Gattner Agata
Published: November 2020

Mining operations cause negative changes in the environment. Therefore, such areas require constant monitoring, which can benefit from remote sensing data. In this article, research was carried out on the environmental impact of underground hard coal mining in the Bogdanka mine, located in the southeastern Poland. For this purpose, spectral indexes, satellite radar interferometry, Geographic Information System (GIS) tools and machine learning algorithms were utilized. Based on optical, radar, geological, hydrological and meteorological data, a spatial model was developed to determine the statistical significance of the selected factors’ individual impact on the occurrence of wetlands. Obtained results show that Normalized Difference Vegetation Index (NDVI) change, terrain height, groundwater level and terrain displacement had a considerable influence on the occurrence of wetlands in the research area. Moreover, the machine learning model developed using the Random Forest algorithm allowed for an efficient determination of potential flooding zones based on a set of spatial variables, correctly detecting 76% area of wetlands. Finally, the GWR (Geographically Weighted Regression (GWR) modelling enabled identification of local anomalies of selected factors’ influence on the occurrence of wetlands, which in turn helped to understand the causes of wetland formation.
Transitioning to a Green Economy—Possible Effects on the Croatian Economy
Authors: Denona Bogovic Nada , Grdic Zvonimira Sverko
Published: November 2020

Following the global economic crisis of 2008, the concept of green economy has become a significant field of interest for scientific research as well as for specific development policies in various countries around the world. More recently, the transition towards green economy has been considered a desirable model and alternative approach to development encompassing all elements of sustainable development—economic, ecological and social. By adopting the 2019 European Green Deal, the European Union has explicitly opted for a new pattern of development that involves all European countries transitioning their economies, i.e., achieving economic growth while significantly reducing their negative environmental impact. The aim of this paper was to assess the possible effects of Croatian economy transitioning in accordance with the European Green Deal strategic framework and resources planned for Croatia in the following EU budgeting period (2021–2027). Based on the regression analysis results and two developed investment scenarios for the green transition, the authors have shown the potential positive effects of such a process on the gross domestic product and on total employment. These results were further supported by arguments based on examples for specific sectors and economic activities. The authors conclude that transitioning towards green economy, i.e., implementing specific green economy policies can serve to push sustainable development in the EU while simultaneously contributing to the implementation of the strategic goals of the European Green Deal.
Acceptance and Influencing Factors of Social Virtual Reality in the Urban Elderly
Authors: Shao Dan , Lee I-Jui
Published: November 2020

In the stage of aging society and population aging, the social needs of the elderly are widely discussed by researchers. Especially driven by the demand of tele-medical treatment and tele-rehabilitation therapy, it is vital for the elderly to integrate into virtual communities by combining social virtual reality (VR) with different medical services and entertainment needs. In addition, affected by the COVID-19 epidemic, it is more difficult for people to have face-to-face contacts. With more remote consultation, entertainment and virtual social connectivity, the application of social VR is more urgent and valuable. However, there is little discussion on the acceptability and influencing factors of social VR among the elderly at present. Therefore, in order to get further data, we used (1) early stage semi-structured interviews and then (2) Unified Theory of Acceptance and Use of Technology (UTAUT) questionnaires for investigation. One hundred fourteen elderly people aged 60–89 living in the metropolitan area of Taipei were taken as the subjects. To help them understand the situation and state of using social VR, these elderly people were asked to use a head-mounted display (HMD) to experience social VR games. The preliminary results showed that the elderly had obvious preference for entertainment (32.4%) and medical treatment (31.3%). The interview showed that this was related to the physiological condition or medical needs of the age range. In order to further understand how social VR would affect the social life of the elderly, we proposed the further demand structure of UTAUT Model based on the interview of both experts and the elderly. The model structures include (1) Performance Expectancy, (2) Perceived Enjoyment, (3) Social Influence, (4) User Attitude, (5) Behavioral Intention, and so on. These structures were applied to conduct interviews and questionnaires to find out the influence extent and relevance of the elderly on different structural needs, and suggestions were given accordingly. The results of the above interviews showed that (1) the elderly thought that the functions of entertaining and interacting of social VR could increase their social opportunities, and also meet medical needs (teleconference, cognitive decline, etc.), (2) the closeness of social relations (between family members, friends, doctors, and places), and also affect the relevance of Perceived Enjoyment (β = 0.77, p = 0.000 < 0.05). The results of these phenomena and interviews showed the interplay between the demand structures and their special relevance. They also indicated that as to social VR technologies, various demands and functional issues of the elderly need to be considered, and these demands would appear in the subtle usage, and different social VR interfaces and functions would emerge based on their special living ways and physical and psychological demands.
A Novel Comprehensive Kinematic and Inverse Dynamic Model for the Flybar-Less Swashplate Mechanism: Application on a Small-Scale Unmanned Helicopter
Authors: Liu Jianbo , Guan Rongqiang , Yao Yongming , Wang Hui , Hu Linqiang
Published: November 2020

In this paper, we propose a novel kinematic and inverse dynamic model for the flybar-less (FBL) swashplate mechanism of a small-scale unmanned helicopter. The swashplate mechanism is an essential configuration of helicopter flight control systems. It is a complex, multi-loop chain mechanism that controls the main rotor. In recent years, the demand for compact swashplate designs has increased owing to the development of small-scale helicopters. The swashplate mechanism proposed in this paper is the latest architectures used for hingeless rotors without a Bell-Hiller mixer. Firstly, the kinematic analysis is derived from the parallel manipulators concepts. Then, based on the principle of virtual work, a methodology for deriving a closed-form dynamic equation of the FBL swashplate mechanism is developed. Finally, the correctness and efficiency of the presented analytical model are demonstrated by numerical examples and the influence factors of the loads acted on actuators are discussed.
AAV Vectored Immunoprophylaxis for Filovirus Infections
Authors: Rghei Amira D. , van Lieshout Laura P. , Santry Lisa A. , Guilleman Matthew M. , Thomas Sylvia P. , Susta Leonardo , Karimi Khalil , Bridle Byram W. , Wootton Sarah K.
Published: November 2020

Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health and economic impact generated by filoviruses. Zaire ebolavirus is responsible for the greatest number of deaths to date and consequently there is now an approved vaccine, Ervebo, while other filovirus species have similar epidemic potential and remain without effective vaccines. Recent clinical success of REGN-EB3 and mAb-114 monoclonal antibody (mAb)-based therapies supports further investigation of this treatment approach for other filoviruses. While efficacious, protection from passive mAb therapies is short-lived, requiring repeat dosing to maintain therapeutic concentrations. An alternative strategy is vectored immunoprophylaxis (VIP), which utilizes an adeno-associated virus (AAV) vector to generate sustained expression of selected mAbs directly in vivo. This approach takes advantage of validated mAb development and enables vectorization of the top candidates to provide long-term immunity. In this review, we summarize the history of filovirus outbreaks, mAb-based therapeutics, and highlight promising AAV vectorized approaches to providing immunity against filoviruses where vaccines are not yet available.
Viral Genomic Characterization and Replication Pattern of Human Polyomaviruses in Kidney Transplant Recipients
Authors: Signorini Lucia , Dolci Maria , Favi Evaldo , Colico Caterina , Ferraresso Mariano , Ticozzi Rosalia , Basile Giuseppe , Ferrante Pasquale , Delbue Serena
Published: November 2020

Human Polyomavirus (HPyV) infections are common, ranging from 60% to 100%. In kidney transplant (KTx) recipients, HPyVs have been associated with allograft nephropathy, progressive multifocal leukoencephalopathy, and skin cancer. Whether such complications are caused by viral reactivation or primary infection transmitted by the donor remains debated. This study aimed to investigate the replication pattern and genomic characterization of BK Polyomavirus (BKPyV), JC Polyomavirus (JCPyV), and Merkel Cell Polyomavirus (MCPyV) infections in KTx. Urine samples from 57 KTx donor/recipient pairs were collected immediately before organ retrieval/transplant and periodically up to post-operative day 540. Specimens were tested for the presence of BKPyV, JCPyV, and MCPyV genome by virus-specific Real-Time PCR and molecularly characterized. HPyVs genome was detected in 49.1% of donors and 77.2% of recipients. Sequences analysis revealed the archetypal strain for JCPyV, TU and Dunlop strains for BKPyV, and IIa-2 strain for MCPyV. VP1 genotyping showed a high frequency for JCPyV genotype 1 and BKPyV genotype I. Our experience demonstrates that after KTx, HPyVs genome remains stable over time with no emergence of quasi-species. HPyVs strains isolated in donor/recipient pairs are mostly identical, suggesting that viruses detected in the recipient may be transmitted by the allograft.
The Molecular Epidemiology and Transmission Dynamics of HIV Type 1 in a General Population Cohort in Uganda
Authors: Ssemwanga Deogratius , Bbosa Nicholas , Nsubuga Rebecca N. , Ssekagiri Alfred , Kapaata Anne , Nannyonjo Maria , Nassolo Faridah , Karabarinde Alex , Mugisha Joseph , Seeley Janet , Yebra Gonzalo , Leigh Brown Andrew , Kaleebu Pontiano
Published: November 2020

The General Population Cohort (GPC) in south-western Uganda has a low HIV-1 incidence rate (<1%). However, new infections continue to emerge. In this research, 3796 HIV-1 pol sequences (GPC: n = 1418, non-GPC sites: n = 1223, Central Uganda: n = 1010 and Eastern Uganda: n = 145) generated between 2003–2015 were analysed using phylogenetic methods with demographic data to understand HIV-1 transmission in this cohort and inform the epidemic response. HIV-1 subtype A1 was the most prevalent strain in the GPC area (GPC and non-GPC sites) (39.8%), central (45.9%) and eastern (52.4%) Uganda. However, in the GPC alone, subtype D was the predominant subtype (39.1%). Of the 524 transmission clusters identified by Cluster Picker, all large clusters (≥5 individuals, n = 8) involved individuals from the GPC. In a multivariate analysis, clustering was strongly associated with being female (adjusted Odds Ratio, aOR = 1.28; 95% CI, 1.06–1.54), being >25 years (aOR = 1.52; 95% CI, 1.16–2.0) and being a resident in the GPC (aOR = 6.90; 95% CI, 5.22–9.21). Phylogeographic analysis showed significant viral dissemination (Bayes Factor test, BF > 3) from the GPC without significant viral introductions (BF < 3) into the GPC. The findings suggest localized HIV-1 transmission in the GPC. Intensifying geographically focused combination interventions in the GPC would contribute towards controlling HIV-1 infections.
Gene Expression Signatures in AML-12 Hepatocyte Cells upon Dengue virus Infection and Acetaminophen Treatment
Authors: Ferreira Jorge G. G. , Gava Sandra G. , Oliveira Eneida S. , Batista Izabella C. A. , Fernandes Gabriel da R. , Mourão Marina M. , Calzavara-Silva Carlos E.
Published: November 2020

Dengue is an acute viral disease caused by Dengue virus (DENV) and is considered to be the most common arbovirus worldwide. The clinical characteristics of dengue may vary from asymptomatic to severe complications and severe organ impairment, particularly affecting the liver. Dengue treatment is palliative with acetaminophen (APAP), usually known as Paracetamol, being the most used drug aiming to relieve the mild symptoms of dengue. APAP is a safe and effective drug but, like dengue, can trigger the development of liver disorders. Given this scenario, it is necessary to investigate the effects of combining these two factors on hepatocyte homeostasis. Therefore, this study aimed to evaluate the molecular changes in hepatocytes resulting from the association between DENV infection and treatment with sub-toxic APAP concentrations. Using an in vitro experimental model of DENV-2 infected hepatocytes (AML-12 cells) treated with APAP, we evaluated the influence of the virus and drug association on the transcriptome of these hepatocytes by RNA sequencing (RNAseq). The virus–drug association was able to induce changes in the gene expression profile of AML-12 cells and here we highlight and explore these changes and its putative influence on biological processes for cellular homeostasis.
Genomic Characterisation of Mushroom Pathogenic Pseudomonads and Their Interaction with Bacteriophages
Authors: Storey Nathaniel , Rabiey Mojgan , Neuman Benjamin W. , Jackson Robert W. , Mulley Geraldine
Published: November 2020

Bacterial diseases of the edible white button mushroom Agaricus bisporus caused by Pseudomonas species cause a reduction in crop yield, resulting in considerable economic loss. We examined bacterial pathogens of mushrooms and bacteriophages that target them to understand the disease and opportunities for control. The Pseudomonastolaasii genome encoded a single type III protein secretion system (T3SS), but contained the largest number of non-ribosomal peptide synthase (NRPS) genes, multimodular enzymes that can play a role in pathogenicity, including a putative tolaasin-producing gene cluster, a toxin causing blotch disease symptom. However, Pseudomonasagarici encoded the lowest number of NRPS and three putative T3SS while non-pathogenic Pseudomonas sp. NS1 had intermediate numbers. Potential bacteriophage resistance mechanisms were identified in all three strains, but only P. agarici NCPPB 2472 was observed to have a single Type I-F CRISPR/Cas system predicted to be involved in phage resistance. Three novel bacteriophages, NV1, ϕNV3, and NV6, were isolated from environmental samples. Bacteriophage NV1 and ϕNV3 had a narrow host range for specific mushroom pathogens, whereas phage NV6 was able to infect both mushroom pathogens. ϕNV3 and NV6 genomes were almost identical and differentiated within their T7-like tail fiber protein, indicating this is likely the major host specificity determinant. Our findings provide the foundations for future comparative analyses to study mushroom disease and phage resistance.
Phylogenetic Investigation of Norovirus Transmission between Humans and Animals
Authors: Villabruna Nele , Izquierdo Lara Ray W. , Szarvas Judit , Koopmans Marion P. G. , Graaf Miranda de
Published: November 2020

Norovirus infections are a leading cause of acute gastroenteritis worldwide, affecting people of all ages. There are 10 norovirus genogroups (GI-GX) that infect humans and animals in a host-specific manner. New variants and genotypes frequently emerge, and their origin is not well understood. One hypothesis is that new human infections may be seeded from an animal reservoir, as human noroviruses have occasionally been detected in animal species. The majority of these sequences were identified as older GII.4 variants, but a variety of other GIIs and GIs have been detected as well. While these sequences share at least 94% nt similarity with human strains, most of them are >98% identical to human strains. The fact that these strains were detected in animals after they had been detected through human surveillance to be already circulating in humans suggests human-to-animal transmission.
Driving Adoption and Commercialization of Subunit Vaccines for Bovine Tuberculosis and Johne’s Disease: Policy Choices and Implications for Food Security
Authors: Ugochukwu Albert I. , Phillips Peter W. B. , Ochieng’ Brian J.
Published: November 2020

Infectious animal diseases, such as Johne’s disease (JD) caused by Mycobacterium avium paratuberculosis (MAP) and bovine tuberculosis (bTB) caused by Mycobacterium bovis, have been a challenge to the livestock industry globally, impacting negatively on animal, human and environmental health, and overall food security. Despite several industry-led and government initiatives and programs aimed at preventing and reducing losses associated with JD and bTB outbreaks, JD has remained endemic in many parts of the world while there have been incidental outbreaks of bTB. While several studies focus on sustainable intensification of food (crop) production as a critical solution to food insecurity, following the existential interconnection between animals, humans and the environment recognized by one health, we frame food security through the lens of animal disease prevention and control, given the importance of livestock products to human health and livelihood. Vaccination has been a popular strategy successfully used in controlling other infectious diseases. The paper focuses on an alternate strategy of two subunit vaccines with companion diagnostics targeted at individual pathogens to attain satisfactory immunological responses for JD and bTB. We examine gaps in vaccine policies, commercialization, and potential strategies that would strengthen animal disease prevention and enhance food security. The potential of public–private partnership in strengthening private sector participation in effective animal disease control and health delivery and the implications for global food security are discussed.
Initial Rotor Position Detection for Permanent Magnet Synchronous Motor Based on High-Frequency Voltage Injection without Filter
Authors: Wang Zhiqiang , Yao Bo , Guo Liyan , Jin Xuefeng , Li Xinmin , Wang Huimin
Published: November 2020

The accurate initial rotor position of a permanent magnet synchronous motor (PMSM) is necessary for starting the motor, and for the position sensorless control method adopted by a PMSM control system under some working conditions. This paper presents a new method to detect the initial rotor position of a permanent magnet synchronous motor (PMSM). The method does not need a low-pass filter, and has strong robustness and a simple calculation method. According to the relationship between high-frequency current response and rotor position angle θ, the rotor position angle can be obtained by arctangent and linear formulae. Finally, the magnetic polarity of the rotor is distinguished according to the change of inductance. In this method, the arctangent function is used to eliminate the filtering process and reduce the influence of the parameter deviation of the motor system on the detection accuracy of the initial position. The experimental results verify the correctness of the theoretical analysis and the effectiveness of the method.
Pregabalin prescribing patterns in Australian general practice, 2012–2018: a cross-sectional study
Authors: Schaffer Andrea L , Busingye Doreen , Chidwick Kendal , Brett Jonathan , Blogg Suzanne
Published: November 2020

Background

In 2013 pregabalin was subsidised by Australia’s Pharmaceutical Benefits Scheme (PBS) for neuropathic pain. Since the subsidy, pregabalin prescribing has been increasing in Australia and so has related harm. There are concerns it is being prescribed for indications other than neuropathic pain, which have little evidence of efficacy.

Aim

To describe pregabalin prescribing in Australian general practice.

Design & setting

A cross-sectional study of patients attending 445 general practice sites in the national MedicineInsight database from March 2012–February 2018.

Method

The following aspects were calculated: the proportion of prescriptions that were for pregabalin per year; the prevalence of pain conditions in patients prescribed pregabalin; and same-day prescribing of pregabalin with opioids or benzodiazepines.

Results

Prescribing increased from 13 per 10 000 to 104 per 10 000 prescriptions between 2012–2013 and 2017–2018. A total of 1 891 623 patients were identified of whom 114 123 (6.0%) were prescribed pregabalin; 49.7% (n = 56 772) had a recorded diagnosis of neuropathic pain. Among people prescribed pregabalin without a recorded diagnosis of neuropathic pain, 43.5% (n = 24 927) had a diagnosis of back problems, 8.8% (n = 5073) chronic pain, and 26.4% (n = 30 146) had no pain diagnosis. Pregabalin was prescribed the same day as an opioid to 38.1% of patients (95% confidence interval [CI] = 37.1% to 39.1%) and a benzodiazepine to 13.1% of patients (95% CI = 12.5% to 13.7%). Patients with a diagnosis of chronic pain had the highest rate of same-day prescribing of pregabalin with an opioid (70.4%, 95% CI = 68.9% to 71.9%) or a benzodiazepine (25.8%, 95% CI = 24.2% to 27.4%)

Conclusion

Substantial increases in pregabalin prescribing were identified in Australian general practice, but only half of patients had a neuropathic pain diagnosis recorded, the only approved indication for subsidy. High rates of same-day prescribing with opioids and benzodiazepines may put patients at increased risk of harm.
Examining opioid prescribing trends for non-cancer pain using an estimated oral morphine equivalence measure: a retrospective cohort study between 2005 and 2015
Authors: Davies Emma , Sewell Bernadette , Jones Mari , Phillips Ceri J , Rance Jaynie Y
Published: November 2020

Background

Over the past 20 years prescription of opioid medicines has markedly increased in the UK, despite a lack of supporting evidence for use in commonly occurring, painful conditions. Prescribing is often monitored by counting numbers of prescriptions dispensed, but this may not provide an accurate picture of clinical practice.

Aim

To use an estimated oral morphine equivalent (OMEQe) dose to describe trends in opioid prescribing in non-cancer pain, and explore if opioid burden differed by deprivation status.

Design & setting

A retrospective cohort study using cross-sectional and longitudinal trend analyses of opioid prescribing data from Welsh Primary Care General Practices (PCGP) took place. Data were used from the Secure Anonymised Information Linkage (SAIL) databank.

Method

An OMEQe measure was developed and used to describe trends in opioid burden over the study period. OMEQe burden was stratified by eight drug groups, which was based on usage and deprivation.

Results

An estimated 643 436 843 milligrams (mg) OMEQe was issued during the study. Annual number of prescriptions increased 44% between 2005 and 2015, while total daily OMEQe per 1000 population increased by 95%. The most deprived areas of Wales had 100 711 696 mg more OMEQe prescribed than the least deprived over the study period.

Conclusion

Over the study period, OMEQe burden nearly doubled, with disproportionate OMEQe prescribed in the most deprived communities. Using OMEQe provides an alternative measure of prescribing and allows easier comparison of the contribution different drugs make to the overall opioid burden.
CRITICISMS OF THE BAUHAUS CONCEPT TODAY
Authors: Aganina N.
Published: November 2020

The article is devoted to the issues of rethinking the design and pedagogical heritage of the Bauhaus on topical design tasks. The research is focused on the critical attitude to the relationship between Bauhaus design and art that developed in the professional environment in the second half of the 20th century. The methodological basis of the research consists of the method of posing problems, historical-genetic and historical-comparative methods, as well as the generalization method. As a result of the research is a conclusion that the possibility of identifying design with art today takes place, due to a change in understanding of the aesthetic aspect
Les plateformes d'épidémiosurveillance : un concept novateur au service de l’efficience des dispositifs de surveillance
Authors: Amar Hélène , Dupuy Céline
Published: November 2020

Créée en 2011, la Plateforme d'épidémiosurveillance en santé animale (ESA) a pour objectif d'apporter un appui scientifique et technique pour améliorer l'efficience des dispositifs de surveillance. Avec une gouvernance associant des acteurs publics et privés ainsi qu'une méthode de travail basée sur le consensus et la confiance entre les acteurs, la Plateforme ESA est un concept novateur qui a su démontrer sa pertinence et son efficacité. Elle a ouvert la voie, en 2018, à la création des Plateformes d'épidémiosurveillance en santé végétale et de surveillance de la chaîne alimentaire. Les trois plateformes partagent l’objectif d’optimisation de la surveillance et les méthodes de travail reposent sur les mêmes principes.
Plan de préparation à une pandémie mondiale dans les animaleries de laboratoire : l’exemple du COVID-19
Authors: Gonin Patrick , Delis Philippe , Lerat Hervé
Published: November 2020

Faire face de façon éthique aux changements drastiques tels que ceux imposés par une pandémie est un défi très complexe pour les animaleries et les chercheurs utilisant des animaux à des fins scientifiques. Il est en effet tout à fait impossible de faire face à de telles situations sans un plan d'urgence spécifique. Un plan générique de gestion des catastrophes ne peut pas suffire car, heureusement, les pandémies sont des événements rares et, à ce titre, elles ne sont généralement pas prévues dans les plans. Nous présentons ici différents outils pour faire face aux changements drastiques qui peuvent survenir dans le cas d'une pandémie, en nous concentrant sur l’optimisation de la conservation des modèles de recherche tout en garantissant des normes élevées et continues de bien-être animal. L'approche proposée est graduée, en tenant compte de la recherche, des chercheurs, des techniciens animaliers, de la chaîne d'approvisionnement et de la logistique.
In silico molecular modelling and docking of allicin, epigallocatechin-3-gallate and gingerol against colon cancer cell proteins
Authors: Elengoe Asita , Sebestian Elina
Published: November 2020

Globally, colon cancer is the second most common cancer among men and women. There is an urgent need to search for a cure for colon cancer. Phytocomponents have shown to exhibit chemoprevention and chemotherapeutic effects related to colon cancer. Thus, phytocomponents can be used as the lead for new drug discovery. Computational biology approaches such as protein modelling and docking have helped in designing substrate-based drugs. In this study, three dimensional (3-D) models of tumour protein (p53), adenomatous polyposis coli (APC) and epidermal growth factor receptor (EGFR) were built using SWISS-MODEL; and their interaction with allicin, epigallocatechin-3-gallate and gingerol through blind docking were evaluated using BSP-SLIM server. These three target proteins are from colon cancer. Physiochemical characters of protein models were assessed through ExPASy’s ProtParam tool. Moreover, the protein structures were validated using PROCHECK, ProQ, ERRAT and VERIFY 3D servers. The protein models’ scores were within normal range. It also showed that the protein models were stable to proceed with the docking approach. Finally, the protein structures (target proteins) were docked successfully with allicin, epigallocatechin-3-gallate and gingerol (phytocomponent). The protein models had a strong interaction with the phytocomponents due to their good binding scores. The best docking scores of the protein-phytocomponent complexes (p53-allicin, APC-Epigallocatechin-3-Gallate and EGFR-gingerol) were 4.968, 6.490, and 6.034, respectively. Protein p53 had the strongest interaction with allicin due to its lowest binding score among all the protein-plant compound complexes. Thus, the results of this study can be used to design and develop a more powerful structure-based drug.
Assessment of quality of life in a retrospective study of total oral rehabilitation of the upper jaw with transzygomatic fixation - Case series
Authors: Pinheiro Luis , Duarte Fernando , Severino Eduardo , Rachel Leeson , Hopper Colin
Published: November 2020

Purpose: Zygomatic implants are becoming more common in oral rehabilitation
of atrophic maxilla. Successful surgery and rehabilitation are mandatory for the
achievement of a well-defined criteria of Quality of Life. However, there is a paucity
of studies reporting on the Health-Related Quality of Life in patients undergoing oral
rehabilitation.
This article aims to developing a specific questionnaire for this particular surgical
and rehabilitation procedure that could be an objective quality outcome measure
of Quality of Life. This should improve our understanding of the impact of zygomatic
implant placement on Quality of Life.
Materials and Methods: The study was performed involving the Eastman Dental
Institute - University College of London, the Faculty of Sciences - University of
Lisbon, and two private practices in Portugal, C.E.R.O-Lisboa and Clitrofa. This was a
retrospective study, evolving 30 patients undergoing transzygomatic surgery.
A modification of the University of Washington – Quality of Life Questionnaire was
designed for this work. The evaluation was made in three-time points: TP1 – Before
surgery, TP2 - After surgery and TP3 - After final rehabilitation.
Results: The means of the increased Quality of Life between the different time-points
were found to be statistically significance at the level of 0.05, with a confidence interval
of 95%.
Conclusion: With this Questionnaire, important data was collected which should allow
treatment developments to optimise patients Quality of Life.
Induced pluripotent stem cells in periodontal regeneration - Narrative review
Authors: Pradeep Kumar Yadalam , Madhuri B , Ravishankar P L , Rajapandain K , Kalaivani V , Chopra Priyanka
Published: November 2020

ABSTRACT
Purpose: Periodontal disease is a severe infection caused by inadequate oral hygiene, resulting in tooth loss due to the bone destruction that supports the teeth. “Induced pluripotent stem cells” (iPSCs or iPS cells) is a sort of pluripotent stem cell that can be acquired out of adult somatic cells like peripheral blood mononuclear cells (PBMCs) or skin fibroblasts through inducing genetic reprogramming genes (Klf4, Oct4, c-Myc, and Sox2).
Materials and Methods: This narrative review shows periodontal regeneration and bone regeneration using iPSCs and also highlights the drawbacks and challenges towards the future using iPSCs.
Results and Discussion: Recent studies have shown greater regeneration when combination of iPSCs and enamel matrix derivates (EMD™) inserted into treatment of periodontal and bone defects.
Conclusions: IPSC is a good alternative cell source in periodontal regeneration.
Vertical Ridge augmentation in posterior mandible - Case report
Authors: Silva Liliana
Published: November 2020

Purpose: This clinical case describes a successful use of a non-resorbable membrane and mixture of autogenous particulated bone with anorganic bovine bone-derived mineral (ABBM) in a severe posterior mandible alveolar defect.
Case report: A combined vertical and horizontal alveolar ridge augmentation was successfully achieved. Detailed clinical steps were described and demonstrated. The patient was rehabilitated with implant supported fixed partial denture with no pink ceramic. This two-staged procedure provides the amount of horizontal ridge width and vertical height to successfully place in the correct position the implants and achieve long term results.
Conclusions: Multicenter, randomised clinical trials are necessary to compare this procedure with other potential clinical solutions.
Return On Equity Terhadap Kinerja Perbankan Dan Nilai Emas Sebagai Variabel Moderasi
Authors: Winarto Edi , . Suryadi
Published: November 2020

This study purposes to determine the effect of Return on Equity on banking performance assessed by Tobin's Q through the value of gold, whether direct or indirect influence. This type of research is an explanatory research with a quantitative approach. The population used in this study were 40 banking sector companies listed on the Indonesia Stock Exchange from 2013 to 2018. The sampling technique used purposive sampling so that the chosen sample was 29. This study used descriptive statistical data analysis and part analysis. The results show that ROE is not a significant negative effect while Gold on Q is a significant negative effect, the indirect coefficient is 0.02139 and the Total Effect is -0.02261, it means that the actual relationship is an indirect relationship better affecting Tobin's Q (Banking Performance ) which also means that indirectly the gold value variable can drive influence on Company Performance.
PENDIDIKAN PENGELOLAAN KEUANGAN KELUARGA, GAYA HIDUP, PEMBELAJARAN SERTA PENGARUHNYA TERHADAP LITERASI KEUANGAN
Authors: Syuliswati Atika
Published: November 2020

The purpose of this study was to examine the effect of family financial management education, life style, and learning in higher education to financial literacy simultaneously and partially to students of the Accounting Department of State Polytechnic Malang. This research is a quantitative research and a sample consist of 142 students of the Accounting Department of State Polytechnic Malang. The method used is survey method using questionnaire given to the respondent to be answered. Question in questionnaire using likert scale. Data analysis method used in this research is multiple linear regression analysis. The results showed simultaneously and partially family financial management education, life style, and learning in higher education have significant effect on financial literacy.
Substantiation of Drinking Water Quality Testing Methods of Choice for the Goals and Objectives of Sanitary and Epidemiologic Expert Examination and Health Risk Assessment
Authors: Fedorov VN , Zaritskaya EV , Novikova YuA , Sladkova YuN , Metelitsa ND
Published: November 2020

Summary. Introduction: As the most important environmental factor having multiple effects on human vital activities and health, drinking water often becomes the subject of predicting adverse health effects. With the purpose of establishing quantitative and/or qualitative characteristics of harmful effects of drinking water chemicals for human health, an integral assessment of drinking water quality with subsequent health risk assessment is carried out. It is based on estimating the risk posed by chronic (carcinogenic and non-carcinogenic) exposures that shows probability of developing a disease. Results: Practical activities of departments and institutions of the Federal Service for Surveillance in the Sphere of Consumers Rights and Human Wellbeing (Rospotrebnadzor) on assessing health effects of environmental factors have demonstrated that, even in concentrations equaling their detection limits in quite a number of test methods, most chemical water pollutants pose unacceptable carcinogenic and non-carcinogenic risks both for the general population and occupational cohorts. Thus, the results of some laboratory methods of testing are inappropriate for an objective human health risk assessment. Conclusions: We describe criteria for selecting methods of the quantitative chemical analysis of drinking water fit for the purposes of sanitary and epidemiologic expert examination combined with a population health risk assessment. The criteria of choice have been elaborated based on the review of regulatory and method documents and results of analytical testing of drinking water quality.
Methodological Approaches to Organization of Drinking Water Quality Monitoring Programs
Authors: Novikova Yu.A. , Myasnikov I.O. , Kovshov A.A. , Tikhonova N.A. , Bashketova N.S.
Published: November 2020

Summary. Introduction: Drinking water is one of the most important environmental factors sustaining life and determining human health. The goal of the Russian Federal Clean Water Project is to improve drinking water quality through upgrading of water treatment and supply systems using advanced technologies, including those developed by the military-industrial complex. The most informative and reliable sources of information for assessing drinking water quality are the results of systematic laboratory testing obtained within the framework of socio-hygienic monitoring (SGM) and production control carried out by water supply organizations. The objective of our study was to formulate approaches to organizing quality monitoring programs for centralized cold water supply systems. Materials and methods: We reviewed programs and results of drinking water quality laboratory tests performed by Rospotrebnadzor bodies and institutions within the framework of SGM in 2017–2018. Results: We established that drinking water quality monitoring in the constituent entities of the Russian Federation differs significantly in the number of monitoring points (566 in the Krasnoyarsk Krai vs 10 in Sevastopol) and measured indicators, especially sanitary and chemical ones (53 inorganic and organic substances in the Kemerovo Region vs one indicator in the Amur Region). Discussion: For a more complete and objective assessment of drinking water quality in centralized cold water supply systems, monitoring points should be organized at all stages of water supply with account for the coverage of the maximum number of people supplied with water from a particular network. Thus, the number of points in the distribution network should depend, inter alia, on the size of population served. In urban settlements with up to 10,000 inhabitants, for example, at least 4 points should be organized while in the cities with more than 3,000,000 inhabitants at least 80 points are necessary. We developed minimum mandatory lists of indicators and approaches to selecting priority indices to be monitored at all stages of drinking water supply.
Problems of Expert Examination of Alteration Projects for Built-In Objects in Multistoried Residential Houses
Authors: Metelitsa ND , Mozzhukhina NA , Noskov SN , Yeremin GB
Published: November 2020

Summary. Background: Running of built-in objects in residential houses can significantly worsen living conditions due to adverse effects of various chemical and physical environmental factors. Yet, sanitary and epidemiological standardization in terms of placement of non-residential premises in residential buildings is not sufficiently regulated, which leads to numerous violations when commissioning non-residential premises in residential buildings. In this regard, the question arises about legal acts regulating design issues and ensuring sanitary and epidemiological well-being when placing non-residential objects in residential buildings and constituting the basis for sanitary and epidemiological expert examinations. Materials and methods: We analyzed regulatory acts setting sanitary and epidemiological requirements for living conditions, placement of public facilities in residential buildings, and alteration projects in residential buildings and examined the archive of public complaints. Results: We established the absence of federal regulations requiring mandatory sanitary and epidemiological expert examination of alteration projects for public facilities built into residential buildings. A significant part of issues related to ensuring sanitary and epidemiological well-being of the population is determined by technical regulations on safety of buildings and structures rather than sanitary legislation. This is the reason why these regulations are included in the scope of accreditation of many inspection bodies of Rospotrebnadzor institutions. Executive authorities and customers of projects for placement of non-residential premises in residential buildings, assuming reconfiguration of built-in facilities, order a sanitary and epidemiological expert examination of alteration projects, rightly believing that elimination of nonconformities at the stage of a separate project will be the most cost-effective solution. Conclusion: It goes without saying that the most efficient solution that can help prevent deterioration of living conditions is a sanitary and epidemiological expert examination requiring amendments and additions to the current sanitary legislation on expediency of such an examination.
Optimization and Cold Test of a Triaxial 2G HTS Power Cable with High Current Capacity
Authors: Vysotsky Vitaly , Zubko Vasily , Fetisov Sergey , Nosov Alexander , Zanegin Sergey
Published: November 2020

Triaxial HTS AC power cables, that incorporates three HTS phases wound around a single core within a single cable is considering the optimal solution for low and medium voltages. Such a design permits to save expensive HTS conductor and to increase the power density transmitted. It is difficult to increase the transmission capacity of a triaxial cable by increasing its operating voltage and therefore, insulation thickness between phases. The other way is to increase the operation current by using a multilayer structure in each phase of the triaxial cable. This task demands a complicated optimization analysis and a precise manufacturing technology. Following our previous studies, we developed and tested the triaxial cable prototype with two layers per phase made of ReBCO wire. The optimal parameters of the cable (twist pitch, diameters of phases, etc.) have been determined using the numerical simulation methods developed. DC and AC tests of the cable has been performed. In the result, the feasibility to provide a uniform current distribution in a triaxial cable, each phase of which consists of two layers, has been demonstrated. With an outer diameter of ~24 mm only, this is the most compact triaxial HTS power cable manufactured and tested up to date with currents up to 4 kA per phase. The anticipated power transfer with three phases of this cable can be as large as ~34 MW.
Solidaritas Sebagai Norma Dasar Dalam Etika Paulus
Authors: Harun Martin
Published: November 2020

Abstract: Solidarity, a modern word and concept, has old roots in the concept of koinonia (fellowship) as it is understood in the New Testament. David G. Horrell even maintains that what we now call solidarity, functions as a meta norm in Paul’s ethics, since phenomena of solidarity are clearly present in the central elements of Paul’s community building. Reference is made to the two basic rituals, Baptism and the Lord’s Supper, which build unity in diversity; to the most frequently used form of address, adelphoi/brothers, which asks for familial treatment of one another; also to the special way in which Paul often tries to restore unity in the middle of conflicts; and especially to his metaphor of the Church as the one body of Christ with many different parts that need and support one another. When speaking about the collections as a sign of the Greek community’s solidarity with the poor community in Jerusalem, Paul refers to Christ’s solidarity as the source of solidarity within and among communities.

Keywords: Solidarity, fellowship, David Horrell, Paul, Ethics, baptism, the Lord’s Supper, brothers, Body of Christ, Christ’s solidarity.

Abstrak: Solidaritas, sebuah kata dan paham modern, memiliki akar yang lama, antara lain dalam paham koinonia (persekutuan), sebagaimana digunakan dalam Alkitab Perjanjian Baru. David G. Horrell mempertahankan bahwa apa yang sekarang kita sebut solidaritas, merupakan norma dasar (meta norm) dalam etika Paulus, sebab fenomen-fenomen solidaritas tampak dalam unsur-unsur sentral pembinaan jemaatnya, antara lain dalam kedua ritual paling dasar, baptisan dan perjamuan Tuhan, yang membina kesatuan dalam perbedaan. Solidaritas juga muncul dalam sebutan paling frekuen, saudara-saudara (adelphoi), yang menuntut suatu etos kekeluargaan. Solidaritas juga tampak dalam banyak seruan Paulus untuk memulihkan kesatuan apabila ia berhadapan dengan perpecahan, dan teristimewa dalam menggambarkan jemaat sebagai satu tubuh Kristus dengan banyak anggota yang berbeda dan saling membutuhkan serta memberi. Dalam konteks kolekte-kolekte sebagai tanda solidaritas antarjemaat, Paulus secara eksplisit menunjuk kepada solidaritas Kristus dengan kita sebagai dasar terdalam dari solidaritas antarumat.

Kata-kata kunci: Solidaritas, persekutuan, David Horrell, Paulus, etika, baptisan, Perjamuan Tuhan, saudara-saudara, Tubuh Kristus, solidaritas Kristus.
Cotinus coggygria Scop. Ekstraktının İn-Vitro Antibakteriyal Aktivitesinin Araştırılması
Authors: GONCAGÜL Gülşen , GÜCEYÜ Çiğdem , GÜNAYDIN Elçin
Published: November 2020

Antik çağlardan günümüze bitkilerin çok sayıda hastalığın tedavisinde kullanıldığı bilinmektedir. Son 30-40 yıl boyunca antibiyotikler hastalıkların tedavisinde yaygın olarak kullanılmasına rağmen, antibakteriyellerin birçok yan etkisinin olduğu ve patojenik mikroorganizmaların antibakteriyellere karşı direnç kazandığı bildirilmiştir. Antibiyotiklere direnç gelişmesi nedeniyle, bitkilerde bulunan terapötik ajanların etkilerinin araştırılması giderek önem kazanmıştır. Güney ve güneydoğu Avrupa’da ve ülkemizde Trakya Bölgesi’nde yetişen Cotinus coggygria Scop. (Tetra) bitkisi antiseptik, antienflamatuar, antioksidan, antibakteriyel, antihemorajik özelliklerinden dolayı farklı coğrafyalarda yaşayan insanların geleneksel tedavilerinde kullanılmaktadır. Bu çalışmada Cotinus coggygria Scop. bitkisinin farklı konsantrasyonlardaki etanol ekstraktının antibakteriyel etkisini belirlemek ve bu etkisini mevcut antibiyotiklerle karşılaştırılması amaçlandı. Çalışmada Cotinus coggygria Scop. bitkisinin Soxhlet yöntemiyle elde edilen etanol ekstraktının antibakteriyal etkisi, günümüzde kullanılan antibakteriyal ajanlar; ampisilin (AM), sefazolin (CZ), sefuroksim (CXM), meropenem (MEM), kolistin (CL), ofloksasin (OFX), sulfametoksazol/ trimetoprim (SXT), tetrasiklin (TE), gentamisin (GM) ile agar difüzyon yöntemiyle karşılaştırıldı. Standart Staphylococcus aureus (ATCC-25923), Escherichia coli (ATCC-25922) ve insanlardan izole edilmiş daha önce farklı antibiyotiklere dirençli olduğu bilinen Acinetobacter baumannii ve Klebsiella pneumoniae kullanıldı. Cotinus coggygria Scop. bitkisinin farklı miktarlarda uygulanan etanol ekstraktının artan miktarlarına paralel olarak, test edilen bakteriler üzerindeki antibakteriyel etkiyi de arttırmıştır. Dirençli oldukları bilinen Acinetobacter baumannii ve Klebsiella pneumoniae'ye karşı uygulanan 20 μl ekstraktın inhibisyon zon çapları sırasıyla 15 ve 17 mm olarak belirlendi. Diğer taraftan, Acinetobacter baumannii’de 9 mm and 13 mm inhibisyon zon çapları sırasıyla kolistin ve gentamisin için tespit edilirken, Klebsiella pneumoniae’de 10 mm ve 12 mm inhibisyon zon çapları sırasıyla kolistin ve ofloksasin için tespit edilmiştir.