bluuebunny/crossref_metadata_2025 huggingface dataset:
Spiritual Needs Assessment in Post-Secular Contexts: An Integrative Review of Questionnaires
Authors: Nissen Ricko D. , Falkø Erik , Stripp Tobias K. , Hvidt Niels Christian
Published: December 2021

Research across healthcare contexts has shown that, if provided appropriately, spiritual care can be of significant benefit to patients. It can be challenging, however, to incorporate spiritual care in daily practice, not least in post-secular, culturally entwined, and pluralist contexts. The aim of this integrative review was to locate, evaluate and discuss spiritual-needs questionnaires from the post-secular perspective in relation to their applicability in secular healthcare. Eleven questionnaires were evaluated and discussed with a focus on religious/spiritual (RS) wording, local culturally entwined and pluralist contexts, and on whether a consensual understanding between patient and healthcare professional could be expected through RS wording. By highlighting some factors involved in implementing a spiritual-needs questionnaire in diverse cultural and vernacular contexts, this article can assist by providing a general guideline. This article offers an approach to the international exchange and implementation of knowledge, experiences, and best practice in relation to the use of spiritual needs-assessment questionnaires in post-secular contexts.
Maternal Mental Health following Ultrasonographic Detection of Fetal Structural Anomaly in the Midst of the COVID-19 Pandemic
Authors: Roslan Nur Rowaidah , Mohd Fauzi Mohd Fadhli , Wan Teng Lim , Nur Azurah Abdul Ghani
Published: December 2021

Prenatal ultrasonographic detection of fetal structural anomaly may adversely affect maternal mental health throughout pregnancy, particularly in the current COVID-19 pandemic. This study aims to prospectively assess maternal stress, anxiety, and depression following ultrasonographic detection of fetal structural anomaly from diagnosis until delivery during the COVID-19 pandemic. A total of 141 pregnant women at a tertiary hospital who underwent detailed scans between 16 and 24 gestational weeks were included and categorized into the study (anomaly finding, n = 65) and comparison (normal finding, n = 76) groups. Self-administered questionnaires of 10-item Perceived Stress Scale (PSS-10) and Hospital Anxiety and Depression Scale (HADS) were used to assess maternal stress, anxiety, and depression at prior detection (T1), two-to-four weeks post-detection (T2), one-to-two weeks prior to delivery (T3), and one-to-two weeks post-delivery (T4). Repeated measures of analysis of variance (ANOVA) were conducted to assess time-, between-group, and time–group interaction effect. In general, maternal stress improved, but anxiety worsened, while depression persisted, over the time from T1 to T4. The average maternal stress and anxiety levels were significantly higher among groups with fetal anomaly. The maternal stress and anxiety level were significantly affected within one-to-two weeks post-detection of fetal structural anomaly. In conclusion, maternal mental health parameters were affected differently during the COVID-19 pandemic, with higher vulnerability of stress and anxiety among pregnant women with fetal structural anomaly particularly within one-to-two weeks post-detection.
Conceptual Model of Emergency Department Utilization among Deaf and Hard-of-Hearing Patients: A Critical Review
Authors: James Tyler G. , Varnes Julia R. , Sullivan Meagan K. , Cheong JeeWon , Pearson Thomas A. , Yurasek Ali M. , Miller M. David , McKee Michael M.
Published: December 2021

Deaf and hard-of-hearing (DHH) populations are understudied in health services research and underserved in healthcare systems. Existing data indicate that adult DHH patients are more likely to use the emergency department (ED) for less emergent conditions than non-DHH patients. However, the lack of research focused on this population’s ED utilization impedes the development of health promotion and quality improvement interventions to improve patient health and quality outcomes. The purpose of this study was to develop a conceptual model describing patient and non-patient (e.g., community, health system, provider) factors influencing ED utilization and ED care processes among DHH people. We conducted a critical review and used Andersen’s Behavioral Model of Health Services Use and the PRECEDE-PROCEED Model to classify factors based on their theoretical and/or empirically described role. The resulting Conceptual Model of Emergency Department Utilization Among Deaf and Hard-of-Hearing Patients provides predisposing, enabling, and reinforcing factors influencing DHH patient ED care seeking and ED care processes. The model highlights the abundance of DHH patient and non-DHH patient enabling factors. This model may be used in quality improvement interventions, health services research, or in organizational planning and policymaking to improve health outcomes for DHH patients.
Knowledge into the Practice against COVID-19: A Cross-Sectional Study from Ghana
Authors: Yeboah Prince , Daliri Dennis Bomansang , Abdin Ahmad Yaman , Appiah-Brempong Emmanuel , Pitsch Werner , Panyin Anto Berko , Adusei Emmanuel Bentil Asare , Razouk Afraa , Nasim Muhammad Jawad , Jacob Claus
Published: December 2021

The COVID-19 pandemic has affected populations globally, including Ghana. Knowledge of the COVID-19 disease, and the application of preventive public health interventions are pivotal to its control. Besides a lockdown, measures taken against the spread of the virus include the wearing of face masks, social distancing, regular hand washing with soap and, more recently, vaccination against the virus. In order to establish a possible link between the knowledge of the disease and compliance with preventive measures, including vaccination, a cross-sectional study employing an interview-structured questionnaire was conducted in six regions of Ghana (n = 1560). An adequate level of knowledge of COVID-19 (69.9%) was reported. The linear multiple regression analysis further explicated the differences in the knowledge of COVID-19 among the respondents by their knowledge of cholera and influenza (adjusted R-Square = 0.643). Despite this profound knowledge of the illness, two thirds of the respondents were unwilling to follow basic preventive measures and only 35.3% were willing to be vaccinated. Amazingly, neither knowledge of COVID-19 nor the socio-demographic characteristics had any meaningful influence on the practice of preventive measures. Personal attitude leading to efficient public compliance with preventive measures, therefore, is a critical issue demanding special attention and effective interventions by the government and locals with authority to curb the spread of the pandemic which surpasses the traditional channels of public health communication. This includes a roll-out of persuasion, possibly including public figures and influencers, and in any case, a balanced and open discussion addressing the acceptance of the COVID-19 vaccine in order to avoid new variants and comparable problems currently facing many countries of Western Europe. Indeed, a profound hesitancy against vaccination may turn African countries such as Ghana for many years into hotspots of new viral variants.
Factors Associated with COVID-19 Vaccine Hesitancy in Mongolia: A Web-Based Cross-Sectional Survey
Authors: Dambadarjaa Davaalkham , Altankhuyag Gan-Erdene , Chandaga Unurtesteg , Khuyag Ser-Od , Batkhorol Bilegt , Khaidav Nansalmaa , Dulamsuren Oyunbileg , Gombodorj Nadmidtseren , Dorjsuren Avirmed , Singh Pramil , Nyam Gunchmaa , Otganbayar Dashpagma , Tserennadmid Nyamsuren
Published: December 2021

Vaccine acceptance in the general public is essential in controlling the coronavirus disease 2019 (COVID-19) pandemic. The study aimed to assess the COVID-19 vaccine hesitancy in the adult population of Mongolia, and determine the associated factors. A total of 2875 individuals from urban and rural areas were recruited, and completed an online survey. Older age, urban residence, previous vaccination, high education, good knowledge of side effects, and a personal view of the importance of vaccines were associated with vaccine acceptability, whereas gender and religion were not. Receiving COVID-19 vaccine information from official government pages was related to a higher acceptance rate. Reliance on social media as a source of COVID-19 vaccine information was associated with high level of vaccine hesitancy. The side effects and the type of the COVID-19 vaccine were a major reason for hesitation. Countering false information regarding COVID-19 vaccines on social media, and promoting vaccine importance on general news websites is necessary. Moreover, providing clear and direct educational materials through official communication channels on the safety and efficacy of COVID-19 vaccines alongside information on COVID-19 symptoms, vaccine side effects, and location of vaccine administration centers among the younger populations, rural residents, and those with lower education is needed.
Evaluation of Spanish Health System during the COVID-19 Pandemic: Accountability and Wellbeing Results
Authors: Peña-Ramos José Antonio , Recuero-López Fátima , Sánchez-Bayón Antonio , Sastre Francisco Javier
Published: December 2021

The COVID-19 pandemic poses a challenge for health systems. For this reason, it is essential to evaluate the management of health systems in the face of the pandemic, identifying the factors that may contribute to its failure or success. This management is more difficult in decentralized countries, since in them, health competencies are distributed among different levels of government. This is the case in Spain, one of the countries most affected by the pandemic. Therefore, the aim of this article is to evaluate how the Spanish health system has managed the COVID-19 pandemic. Four factors related to health management are analyzed: transparency, communication, reputation and well-being generated. For this purpose, a quantitative analysis is used with the contrast of secondary sources, such as the Merco rankings or survey data from the Centro de Investigaciones Sociológicas (Sociological Research Center). The results show that although the flow of communication about the health system increases considerably, such information comes mainly from the media, with a deficit in the transparency of health management. Likewise, although the reputation of the health system increases at the beginning of the pandemic, as it progresses, there is a deterioration in citizen satisfaction with the healthcare management and the services provided, as well as in the well-being generated by them. This study may have implications for decision making by public authorities regarding the different factors of health management.
Green TFP Heterogeneity in the Ports of China’s Pilot Free Trade Zone under Environmental Constraints
Authors: Hu Zongbiao , Lan Feng , Xu Han
Published: December 2021

In the context of China’s Pilot Free Trade Zone (FTZ), ports have a new opportunity to realize high-quality development. Based on the analysis of the current situation of pollutant emissions from ports in China’s Pilot Free Trade Zones (FTZs), this paper introduces environmental factors into the analysis framework of the total factor productivity (TFP) of ports in China’s FTZs, and uses the Global Malmquist–Luenberger index method to analyze the evolution trend and heterogeneity of green TFP in 28 ports of China’s 19 FTZs from 2011 to 2017. The results show that firstly, the emissions of sulfur dioxide (SO2), nitrogen oxides (NOX) and other pollutants in China’s FTZs have been decreasing year by year. Secondly, both the green TFP and the traditional TFP of the ports in FTZs are on the rise. The absence of environmental factors leads to the underestimation of the TFP of ports. For the green TFP, the main source of its growth is technological progress. Thirdly, there is obvious port heterogeneity in the green TFP of FTZ ports. Nanjing Port has the highest green TFP growth rate, with an average annual growth rate of 21.95%. Ningbo Port, which ranks 14th, has an average annual growth rate of 5.46%. Fuzhou Port, which is rated last, has negative growth. Fourthly, there is also obvious types and regional heterogeneity in the green TFP of FTZ ports. When categorized by type, the average annual growth rate of green TFP in inland ports is significantly higher than that of coastal ports. When categorized by region, the descending order of the average annual growth rate of green TFP is the western region, the eastern region and the central region. Fifthly, the green TFP differences among the eastern, central, and western regions, as well as between inland ports and coastal ports, are shrinking. Moreover, the green TFP differences within inland ports and coastal ports and within central ports and eastern ports are also shrinking, implying there may be σ convergence. The conclusions of this paper have important implications for the scientific understanding of the heterogeneity of green TFP growth in ports in China’s FTZs, and how to promote the green development of ports in China’s FTZs under environmental constraints.
Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma
Authors: Feola Alessandro , Ciamarra Paola , De Simone Mariavictoria , Carfora Anna , Mansueto Gelsomina , Campobasso Carlo Pietro
Published: December 2021

Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes.
Systematic Review and Meta-Analysis of the Relationship between Actual Exercise Intensity and Rating of Perceived Exertion in the Overweight and Obese Population
Authors: Yu Hongli , Sun Chen , Sun Bo , Chen Xiaohui , Tan Zhijun
Published: December 2021

The number of overweight (OW) and obese (OB) children, adolescents, and adults has increased globally. Exercise intensity, both actual and perceived, is a significant factor in a variety of health-related investigations and rehabilitation trainings. Despite this, literature on the connection between actual exercise intensity and the rating of perceived exertion (RPE) in overweight and obese populations is lacking. A systematic review, meta-analysis, combined analysis of variance (Brown–Forsythe ANOVA), and Spearman correlation were performed to fill this gap. After preliminary assessments, ten studies were classified as having a low risk of bias and a degree of heterogeneity (I2 = 34%; p = 0.05). The RPE scores (F = 0.032; p = 0.859), physiological index (percentage of maximal heart rate (%HRmax) (F = 0.028; p = 0.869), and percentage of maximal oxygen uptake (%VO2max) (F = 2.434; p = 0.136) demonstrated consistency without being significantly different between the normal weight (NW) and OW/OB groups. The RPE scores varied by age (NW (coefficient values) = 0.677 ***, OW = 0.585 **), as well as by indoor temperature (OW only, coefficient values = 0.422 *), body mass index (NW (coefficient values) = 0.516 **, OW = 0.580 **), and test time (NW only, coefficient values = 0.451 *). We conclude that RPE is appropriate for the following OW and OB people: (1) those who are older than 21.5 (the lowest age in the group of ≥18) years old and younger than 58.6 (the highest age in the group of ≥18) years old, without any other diseases, and (2) those who engage in low-intensity exercise while maintaining a standard indoor temperature. Future studies may address alternative techniques for increasing the reliability of longitudinal comparisons and gender comparisons, as well as investigate other possible confounding factors.
A Bayesian Approach to Estimate the Spatial Distribution of Crowdsourced Radiation Measurements around Fukushima
Authors: Hultquist Carolynne , Oravecz Zita , Cervone Guido
Published: December 2021

Citizen-led movements producing spatio-temporal big data are potential sources of useful information during hazards. Yet, the sampling of crowdsourced data is often opportunistic and the statistical variations in the datasets are not typically assessed. There is a scientific need to understand the characteristics and geostatistical variability of big spatial data from these diverse sources if they are to be used for decision making. Crowdsourced radiation measurements can be visualized as raw, often overlapping, points or processed for an aggregated comparison with traditional sources to confirm patterns of elevated radiation levels. However, crowdsourced data from citizen-led projects do not typically use a spatial sampling method so classical geostatistical techniques may not seamlessly be applied. Standard aggregation and interpolation methods were adapted to represent variance, sampling patterns, and the reliability of modeled trends. Finally, a Bayesian approach was used to model the spatial distribution of crowdsourced radiation measurements around Fukushima and quantify uncertainty introduced by the spatial data characteristics. Bayesian kriging of the crowdsourced data captures hotspots and the probabilistic approach could provide timely contextualized information that can improve situational awareness during hazards. This paper calls for the development of methods and metrics to clearly communicate spatial uncertainty by evaluating data characteristics, representing observational gaps and model error, and providing probabilistic outputs for decision making.
Functional Classification of Urban Parks Based on Urban Functional Zone and Crowd-Sourced Geographical Data
Authors: Cao Su , Du Shihong , Yang Shuwen , Du Shouhang
Published: December 2021

Urban parks have important impacts on urban ecosystems and in disaster prevention. They also have diverse social functions that are important to the living conditions and spatial structures of cities. Identifying and classifying the different types of urban parks are important for analyzing the sustainable development and the greening progress in cities. Existing studies have predominantly focused on the data extraction of urban green spaces as a whole, while there have been relatively few studies that have considered different categories of urban parks and their impact, which makes it difficult to characterize or predict the spatial distribution and structures of urban parks and limits further refinement of urban research. At present, the classification of urban parks relies on the physical features observed in remote sensing images, but these methods are limited when mapping the diverse functions and attributes of urban parks. Crowd-sourced geographic data may more accurately express the social functions of points of interest (POIs) in cities, and, therefore, employing open data sources may assist in data extraction and the classification of different types of urban parks. This paper proposed a multi-source data fusion approach for urban park classification including POI and urban functional zone (UFZ) data. First, the POI data were automatically reclassified using improved natural language processing (NLP) (i.e., text similarity measurements and topic modeling) to establish the links between urban park green-space types and POIs. The reclassified POI data as well as the UFZ data were then subjected to scene-based data fusion, and various types of urban parks were extracted using data attribute analysis and social attribute recognition for urban park mapping. Experimental analysis was conducted across Beijing and Hangzhou to verify the effectiveness of the proposed method, which had an overall classification accuracy of 82.8%. Finally, the urban park types of the two cities were compared and analyzed to obtain the characteristics of urban park types and structures in the two cities, which have different climates and urban structures.
Oxidation of Various Kraft Lignins with a Bacterial Laccase Enzyme
Authors: Mayr Sebastian A. , Subagia Raditya , Weiss Renate , Schwaiger Nikolaus , Weber Hedda K. , Leitner Johannes , Ribitsch Doris , Nyanhongo Gibson S. , Guebitz Georg M.
Published: December 2021

Modification of kraft lignin (KL), traditionally uses harsh and energy-demanding physical and chemical processes. In this study, the potential of the bacterial laccase CotA (spore coating protein A) for oxidation of KL under mild conditions was assessed. Thereby, the efficiency of CotA to oxidize both softwood and hardwood KL of varying purity at alkaline conditions was examined. For the respective type of wood, the highest oxidation activity by CotA was determined for the medium ash content softwood KL (MA_S) and the medium ash content hardwood KL (MA_H), respectively. By an up to 95% decrease in fluorescence and up to 65% in phenol content coupling of the structural lignin units was indicated. These results correlated with an increase in viscosity and molecular weight, which increased nearly 2 and 20-fold for MA_H and about 1.3 and 6.0-fold for MA_S, respectively. Thus, this study confirms that the CotA laccase can oxidize a variety of KL at alkaline conditions, while the origin and purity of KL were found to have a major impact on the efficiency of oxidation. Under the herein tested conditions, it was observed that the MA_H KL showed the highest susceptibility to CotA oxidation when compared to the other hardwood KLs and the softwood KLs. Therefore, this could be a viable method to produce sustainable resins and adhesives.
Mechanisms and Regulation of Cellular Senescence
Authors: Roger Lauréline , Tomas Fanny , Gire Véronique
Published: December 2021

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype. There are different types of senescent cells, and senescence can be induced in response to many DNA damage signals. Senescent cells accumulate in different tissues and organs where they have distinct physiological and pathological functions. Despite this diversity, all senescent cells must be able to survive in a nondividing state while protecting themselves from positive feedback loops linked to the constant activation of the DNA damage response. This capacity requires changes in core cellular programs. Understanding how different cell types can undergo extensive changes in their transcriptional programs, metabolism, heterochromatin patterns, and cellular structures to induce a common cellular state is crucial to preventing cancer development/progression and to improving health during aging. In this review, we discuss how senescent cells continuously evolve after their initial proliferative arrest and highlight the unifying features that define the senescent state.
From Spheroids to Organoids: The Next Generation of Model Systems of Human Cardiac Regeneration in a Dish
Authors: Scalise Mariangela , Marino Fabiola , Salerno Luca , Cianflone Eleonora , Molinaro Claudia , Salerno Nadia , De Angelis Antonella , Viglietto Giuseppe , Urbanek Konrad , Torella Daniele
Published: December 2021

Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from the differentiation of stem cells. The growing interest in the use of organoids arises from their ability to mimic the biology and physiology of specific tissue structures in vitro. Organoids indeed represent promising systems for the in vitro modeling of tissue morphogenesis and organogenesis, regenerative medicine and tissue engineering, drug therapy testing, toxicology screening, and disease modeling. Although 2D cell cultures have been used for more than 50 years, even for their simplicity and low-cost maintenance, recent years have witnessed a steep rise in the availability of organoid model systems. Exploiting the ability of cells to re-aggregate and reconstruct the original architecture of an organ makes it possible to overcome many limitations of 2D cell culture systems. In vitro replication of the cellular micro-environment of a specific tissue leads to reproducing the molecular, biochemical, and biomechanical mechanisms that directly influence cell behavior and fate within that specific tissue. Lineage-specific self-organizing organoids have now been generated for many organs. Currently, growing cardiac organoid (cardioids) from pluripotent stem cells and cardiac stem/progenitor cells remains an open challenge due to the complexity of the spreading, differentiation, and migration of cardiac muscle and vascular layers. Here, we summarize the evolution of biological model systems from the generation of 2D spheroids to 3D organoids by focusing on the generation of cardioids based on the currently available laboratory technologies and outline their high potential for cardiovascular research.
eIF5A-Independent Role of DHPS in p21CIP1 and Cell Fate Regulation
Authors: Becker Andrew E. , Wu Pui-Kei , Park Jong-In
Published: December 2021

Deoxyhypusine synthase (DHPS) catalyzes the first step of hypusination of the elongation translation factor 5A (eIF5A), and these two proteins have an exclusive enzyme–substrate relationship. Here we demonstrate that DHPS has a role independent of eIF5A hypusination in A375 and SK-MEL-28 human melanoma cells, in which the extracellular signal regulated kinase 1/2 (ERK1/2) pathway is deregulated. We found that RNA interference of DHPS induces G0/G1 cell cycle arrest in association with increased p21CIP1 expression in these cells whereas eIF5A knockdown induces cell death without increasing p21CIP1 expression. Interestingly, p21CIP1 knockdown switched DHPS knockdown-induced growth arrest to cell death in these cells, suggesting a specific relation between DHPS and p21CIP1 in determining cell fate. Surprisingly, ectopic expression of DHPS-K329R mutant that cannot hypusinate eIF5A abrogated DHPS knockdown-induced p21CIP1 expression in these cells, suggesting a non-canonical role of DHPS underlying the contrasting effects of DHPS and eIF5A knockdowns. We also show that DHPS knockdown induces p21CIP1 expression in these cells by increasing CDKN1A transcription through TP53 and SP1 in an ERK1/2-dependent manner. These data suggest that DHPS has a role independent of its ability to hypusinate eIF5A in cells, which appears to be important for regulating p21CIP1 expression and cell fate.
A Novel Reference for Bt-Resistance Mechanism in Plutella xylostella Based on Analysis of the Midgut Transcriptomes
Authors: Xiong Lei , Liu Zhaoxia , Shen Lingling , Xie Chao , Ye Min , Li Zeyun , Zhang Zhen , Li Jingge , Dong Yi , You Minsheng , You Shijun
Published: December 2021

The diamondback moth, Plutella xylostella, is a lepidopteran insect that mainly harms cruciferous vegetables, with strong resistance to a variety of agrochemicals, including Bacillus thuringiensis (Bt) toxins. This study intended to screen genes associated with Bt resistance in P. xylostella by comparing the midgut transcriptome of Cry1Ac-susceptible and -resistant strains together with two toxin-treated strains 24 h before sampling. A total of 12 samples were analyzed by BGISEQ-500, and each sample obtained an average of 6.35 Gb data. Additionally, 3284 differentially expressed genes (DEGs) were identified in susceptible and resistant strains. Among them, five DEGs for cadherin, 14 for aminopeptidase, zero for alkaline phosphatase, 14 for ATP binding cassette transport, and five heat shock proteins were potentially involved in resistance to Cry1Ac in P. xylostella. Furthermore, DEGs associated with “binding”, “catalytic activity”, “cellular process”, “metabolic process”, and “cellular anatomical entity” were more likely to be responsible for resistance to Bt toxin. Thus, together with other omics data, our results will offer prospective genes for the development of Bt resistance, thereby providing a brand new reference for revealing the resistance mechanism to Bt of P. xylostella.
Risk Assessment of Insecticides Used in Tomato to Control Whitefly on the Predator Macrolophus basicornis (Hemiptera: Miridae)
Authors: Matioli Thaís Fagundes , da Silva Mariana Rosa , de Bastos Pazini Juliano , Barroso Geovanny , Vieira Júlia Gabriela Aleixo , Yamamoto Pedro Takao
Published: December 2021

The generalist mirid predator Macrolophus basicornis may contribute to Integrated Pest Management (IPM) of Bemisia tabaci in tomato crops. It is important to know the compatibility of the chemicals used to control this pest with this promising biological control agent. Seven insecticides were tested to investigate their toxicity to the predator. For four of the products, the LC50 for adults were determined. Buprofezin, cyantraniliprole and spiromesifen did not cause lethality and were classified as harmless. Acetamiprid, bifenthrin, etofenprox + acetamiprid and pyriproxyfen + acetamiprid caused acute toxicity and were classified as harmful. LT50 for all harmful insecticides were relatively low, ranging from 1.8 to 3.2 days. Moreover, these four insecticides have low LC50, with acetamiprid (0.26 mg a.i. L−1) as the lowest, followed by bifenthrin (0.38 mg a.i. L−1), etofenprox + acetamiprid (4.80 mg a.i. L−1) and pyriproxyfen + acetamiprid (8.71 mg a.i. L−1). However, the calculated risk quotient (RQ) values demonstrated that these insecticides were mostly ecologically safe for this predator, except for acetamiprid, classified as slightly to moderately toxic. The present study can contribute to the use of M. basicornis as a biological control agent on tomato crops and to compatible use with the insecticides tested, according to IPM strategies.
A Review of the Genus Cloeon from Chinese Mainland (Ephemeroptera: Baetidae)
Authors: Ying Xiaoli , Li Wenjuan , Zhou Changfa
Published: December 2021

The widely distributed and species diverse genus Cloeon Leach, 1815 has never been reviewed in China, although nine species names have been reported from this country. After checking types of two species (C. viridulum and C. apicatum) and newly collected materials from more than 50 sites, four species are recognized, compared, and photographed in this research. Among them, the species C. bicolor Kimmins, 1947 is first recorded in China, and its nymphs are described for the first time. The distribution in China of two other species (C. dipterum (Linnaeus, 1761) and C. harveyi (Kimmins, 1947)) are also confirmed. The two species established by Navás (C.apicatum Navás, 1933 = C. navasi Bruggen, 1957, C. pielinum Navás, 1933, syn. nov.) and the species C. micki named by Tong and Dudgeon in 2021 are synonymized with C. viridulum Navás, 1931—the fourth species in this study. Furthermore, the C. virens Klapálek, 1905 from the Chinese mainland, found by Ulmer in 1925, is also regarded as the last species. Among the four species, the C. dipterum and C. harveyi seem closer because of the similar female color patterns of their stigma and ventral abdomen, while the species C. viridulum and C. bicolor are more alike because they have neither pigmented stigma nor stripes on abdominal sterna.
Common Arterial Trunk Associated with Functionally Univentricular Heart: Anatomical Study and Review of the Literature
Authors: Chatila Sami , Houyel Lucile , Hily Manon , Bonnet Damien
Published: December 2021

Common arterial trunk (CAT) is a rare congenital heart disease that is commonly included into the spectrum of conotruncal heart defects. CAT is rarely associated with functionally univentricular hearts, and only few cases have been described so far. Here, we describe the anatomical characteristics of CAT associated with a univentricular heart diagnosed in children and fetuses referred to our institution, and we completed the anatomical description of this rare condition through an extensive review of the literature. The complete cohort ultimately gathered 32 cases described in the literature completed by seven cases from our unit (seven fetuses and one child). Four types of univentricular hearts associated with CAT were observed: tricuspid atresia or hypoplastic right ventricle in 16 cases, mitral atresia or hypoplastic left ventricle in 12 cases, double-inlet left ventricle in 2 cases, and unbalanced atrioventricular septal defect in 9 cases. Our study questions the diagnosis of CAT as the exclusive consequence of an anomaly of the wedging process, following the convergence between the embryonic atrioventricular canal and the common outflow tract. We confirm that some forms of CAT can be considered to be due to an arrest of cardiac development at the stages preceding the convergence.
Differences in Adiposity Profile and Body Fat Distribution between Forwards and Backs in Sub-Elite Spanish Female Rugby Union Players
Authors: Escrivá Dolores , Caplliure-Llopis Jordi , Benet Inmaculada , Mariscal Gonzalo , Mampel Juan Vicente , Barrios Carlos
Published: December 2021

The purpose of this study was to analyze the adiposity profile and the body fat distribution in 56 sub-elite female rugby union players involved in the Spanish National Women’s Rugby Union Championships. The participants included in this study, which was the first to analyze sub-elite players, show thinner skinfolds, lower fat mass, and lesser fat percentage than previously reported for elite female rugby union players. Forwards were heavier and had higher body mass index (BMI) and fat mass, thicker skinfolds, and higher fat percentage than back players. Forwards also possessed significantly greater total fat-free mass than backs. All these differences were applicable only to players under 25 years of age. A negative correlation between age and both abdominal and lower extremity fat was found in forward players but not in the backs. Both Yuhasz and Faulkner equations tended to underestimate fat percentage in comparison to Reilly equation. Although Yuhasz equation provided higher systematic error, random error was lower in comparison to Faulkner equation. This study shows the relevance of analyzing and monitoring adiposity in female rugby union players to optimize adaptation to the sports requirements of different playing positions and age.
Management of Osteoblastoma and Giant Osteoid Osteoma with Percutaneous Thermoablation Techniques
Authors: Izzo Antonio , Zugaro Luigi , Fascetti Eva , Bruno Federico , Zoccali Carmine , Arrigoni Francesco
Published: December 2021

Osteoblastoma (OB) is a rare, benign bone tumor, accounting for 1% of all primary bone tumors, which occurs usually in childhood and adolescence. OB is histologically and clinically similar to osteoid osteoma (OO), but it differs in size. It is biologically more aggressive and can infiltrate extraskeletal tissues. Therapy is required because of severe bone pain worsening at night. Moreover, non-steroid anti-inflammatory drugs (NSAIDs) are not a reasonable long-term treatment option in young patients. Surgical excision, considered the gold standard in the past, is no longer attractive today due to its invasiveness and the difficulty in performing a complete resection. The treatment of choice is currently represented by percutaneous thermoablation techniques. Among these, Radiofrequency ablation (RFA) is considered the gold standard treatment, even when the lesions are located in the spine. RFA is a widely available technique that has shown high efficacy and low complication rates in many studies. Other percutaneous thermoablation techniques have been used for the treatment of OB, including Cryoablation (CA) and laser-ablation (LA) with high success rates and low complications. Nevertheless, their role is limited, and further studies are necessary.
Abnormalities in Cutaneous Microcirculation in Patients with Alzheimer’s Disease, Mild Cognitive Impairment, and Chronic Insomnia Disorder
Authors: Yu Sebastian , Hsu Chung-Yao , Chuang Hung-Yi , Yang Chen-Cheng , Lai Chiou-Lian , Yu Hsin-Su
Published: December 2021

Impaired sympathetic response is frequently observed in neurodegenerative diseases, such as Alzheimer’s disease (AD). On the other hand, chronic insomnia disorder (CID) is also often accompanied by activation of sympathetic nerves. Considering that cutaneous microcirculation reflects sympathetic tone, we hypothesized that baseline cutaneous microcirculation in fingers, as detected by laser Doppler flowmetry (LDF), differs among patients with mild cognitive impairment (MCI), AD, and CID. As light therapy is one of the adjunctive treatments for AD and CID, we designed a randomized controlled cross-over trial of light therapy through eyes for 12 weeks with red light as treatment and green light as control limb, and examined if light therapy has an impact on cutaneous microcirculation. Before light therapy, patients with AD had significantly lower baseline cutaneous perfusion than those with CID in left and right first to fourth fingers. After red light therapy, however, cutaneous perfusion of fingers in CID patients significantly decreased (right fingers, before vs. after = 227.25 ± 62.00 vs. 162.00 ± 49.34, p = 0.007; left fingers, before vs. after = 228.99 ± 58.80 vs. 177.41 ± 59.41, p = 0.003) while cutaneous perfusion of fingers in CID patients did not significantly change after green light therapy. Light therapy with red light also significantly increased cutaneous finger perfusion in patients with AD (right fingers, before vs. after = 130.13 ± 49.82 vs. 172.38 ± 38.32, p = 0.043). Our results suggest that cutaneous perfusion is a useful tool to detect sympathetic dysfunction in patients with CID and AD, and that light therapy with red light is a potential therapeutic intervention to reverse impaired sympathetic function in patients with CID and patients with AD.
Community Initiatives to Promote Basic Life Support Implementation—A Scoping Review
Authors: Scapigliati Andrea , Zace Drieda , Matsuyama Tasuku , Pisapia Luca , Saviani Michela , Semeraro Federico , Ristagno Giuseppe , Laurenti Patrizia , Bray Janet E. , Greif Robert ,   on behalf of the International Liaison Committee on Resuscitation Education, Implementation and Teams Task Force
Published: December 2021

Introduction: Early intervention of bystanders (the first links of the chain of survival) have been shown to improve survival and good neurological outcomes of patients suffering out-of-hospital cardiac arrest (OHCA). Many initiatives have been implemented to increase the engagement of communities in early basic life support (BLS) and cardiopulmonary resuscitation (CPR), especially of lay people with no duty to respond. A better knowledge of the most effective initiatives might help improve survival and health system organization. Aim of the scoping review: To assess the impact of specific interventions involving lay communities on bystander BLS rates and other consistent clinical outcomes, and to identify relevant knowledge gaps. Methods: This scoping review was part of the continuous evidence evaluation process of the International Liaison Committee on Resuscitation (ILCOR), and was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. We performed a literature search using the PubMed, EMBASE, and Cochrane databases until 1 February 2021. The screening process was conducted based on predefined inclusion/exclusion criteria, and for each included study, we performed data extraction focusing on the type of intervention implemented, and the impact of these interventions on the specific OHCAs outcomes. Results: Our search strategy identified 19 eligible studies, originating mainly from the USA (47.4%) and Denmark (21%). The type of intervention included in 57.9% of cases was a community CPR training program, in 36.8% bundled interventions, and in 5.3% mass-media campaigns. The most commonly reported outcome for OHCAs was bystander CPR rate (94.7%), followed by survival to hospital discharge (36.8%), proportion of people trained (31.6%), survival to hospital discharge with good neurological outcome (21%), and Return of Spontaneous Circulation (10.5%). Community training programs and bundled interventions improved bystander CPR in most of the included studies. Conclusion: Based on the results of our scoping review, we identified the potential benefit of community initiatives, such as community training in BLS, even as part of bundled intervention, in order to improve bystander CPR rates and patient outcomes.
Non-Alcoholic Fatty Liver Disease (NAFLD) and Bariatric/Metabolic Surgery as Its Treatment Option: A Review
Authors: Głuszyńska Paulina , Lemancewicz Dorota , Dzięcioł Janusz Bogdan , Razak Hady Hady
Published: December 2021

The prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) has considerably increased over the last years. NAFLD is currently the most common cause of chronic liver disease in the developing world. The diagnosis of NAFLD/NASH is often incidental, as the early-stage of disease is frequently free of symptoms. Most patients recognized with NAFLD have severe obesity and other obesity-related disease such as type 2 diabetes mellitus (T2DM), insulin-resistance, dyslipidemia and hypertension. The only proven method for NAFLD improvement and resolution is weight loss. Bariatric surgery leads to significant and long-term weight loss as well as improvement of coexisting diseases. There is a lot of evidence suggesting that metabolic/bariatric surgery is an effective method of NAFLD treatment that leads to reduction in steatosis, hepatic inflammation and fibrosis. However, there is still a need to perform long-term studies in order to determine the role of bariatric surgery as a treatment option for NAFLD and NASH. This review discusses current evidence about epidemiology, pathogenesis and treatment options for NAFLD including bariatric/metabolic surgery and its effect on improvement and resolution of NAFLD.
The Complement System, T Cell Response, and Cytokine Shift in Normotensive versus Pre-Eclamptic and Lupus Pregnancy
Authors: Ancuța Eugen , Zamfir Radu , Martinescu Gabriel , Crauciuc Dragoș Valentin , Ancuța Codrina
Published: December 2021

Successful pregnancy requires an immunological shift with T helper CD4+ bias based on disbalance Th1/Th17 versus Th2/T regulatory (Tregs) required to induce tolerance against the semi-allogeneic fetus and placenta and to support fetal growth. Considered a pregnancy-specific hypertensive disorder, pre-eclampsia is characterized by multifaceted organ involvement related to impaired maternal immune tolerance to paternal antigens triggered by hypoxic placental injury as well as excessive local and systemic anti-angiogenic and inflammatory factor synthesis. Both systemic and local Th1/Th2 shift further expands to Th17 cells and their cytokines (IL-17) complemented by suppressive Treg and Th2 cytokines (IL-10, IL-4); alterations in Th17 and Tregs cause hypertension during pregnancy throughout vasoactive factors and endothelial dysfunction, providing an explanatory link between immunological and vascular events in the pathobiology of pre-eclamptic pregnancy. Apart from immunological changes representative of normotensive pregnancy, lupus pregnancy is generally defined by higher serum pro-inflammatory cytokines, lower Th2 polarization, defective and lower number of Tregs, potential blockade of complement inhibitors by anti-phospholipid antibodies, and similar immune alterations to those seen in pre-eclampsia. The current review underpins the immune mechanisms of pre-eclampsia focusing on local (placental) and systemic (maternal) aberrant adaptive and innate immune response versus normotensive pregnancy and pregnancy in systemic autoimmune conditions, particularly lupus.
Single-Port versus Multiple-Port Robot-Assisted Radical Prostatectomy: A Systematic Review and Meta-Analysis
Authors: Fahmy Omar , Fahmy Usama A. , Alhakamy Nabil A. , Khairul-Asri Mohd Ghani
Published: December 2021

Background: Single-port robotic-assisted radical prostatectomy has been reported as a safe and feasible technique. However, recent studies comparing single-port versus multiple-port robotic radical prostatectomy have displayed conflicting results. Objectives: To investigate the benefit of single-port robotic radical prostatectomy and the impact on outcome compared to multiple-port robotic radical prostatectomy. Methods: Based on PRISMA and AMSTAR criteria, a systematic review and meta-analysis were carried out. Finally, we considered the controlled studies with two cohorts (one cohort for single-port RARP and the other cohort for multiple-port RARP). For statistical analysis, Review Manager (RevMan) software version 5.4 was used. The Newcastle-Ottawa Scale was employed to assess the risk of bias. Results: Five non-randomized controlled studies with 666 patients were included. Single-port robotic radical prostatectomy was associated with shorter hospital stays. Only 60.6% of single-port patients (109/180) required analgesia compared to 90% (224/249) of multiple-port patients (Z = 3.50; p = 0.0005; 95% CI 0.07:0.47). Opioid administration was also significantly lower in single-port patients, 26.2% (34/130) vs. 56.6% (77/136) (Z = 4.90; p < 0.00001; 95% CI 0.15:–0.44) There was no significant difference in operative time, blood loss, complication rate, positive surgical margin rate, or continence at day 90. Conclusion: The available data on single-port robotic radical prostatectomy is very limited. However, it seems comparable to the multiple-port platform in terms of short-term outcomes when performed with expert surgeons. Single-port prostatectomies might provide a shorter hospital stay and a lower requirement for opioids; however, randomized trials with long-term follow-up are mandatory for valid comparisons.