bluuebunny/crossref_metadata_2025 huggingface dataset:
SDG 4, Academic Integrity and Artificial Intelligence: Clash or Win-Win Cooperation?
Authors: Artyukhov Artem , Wołowiec Tomasz , Artyukhova Nadiia , Bogacki Sylwester , Vasylieva Tetiana
Published: September 2024

This article investigates the relationship between Sustainable Development Goal 4 (SDG 4), academic integrity as its part, and artificial intelligence (AI) through a bibliometric analysis, assessing whether this intersection represents a clash or win-win cooperation. SDG 4 aims to ensure equitable access to quality education, while AI technologies have the potential to enhance educational practices but demote academic integrity. By analyzing a comprehensive body of the literature, this study identifies key trends and thematic areas where AI is applied in educational settings, particularly concerning maintaining academic integrity. The findings reveal a growing body of research highlighting AI’s role in personalizing learning experiences, improving educational accessibility, and supporting educators’ teaching methodologies. However, challenges such as ethical considerations, data privacy, and the digital divide are also addressed, indicating potential conflicts that need to be navigated. Ultimately, this analysis suggests that while there are significant opportunities for synergy between AI and SDG 4, the management of careful implementation and policy frameworks is essential to ensure that AI serves as a tool for promoting inclusive and sustainable education rather than exacerbating existing inequalities. AI transforms science management by enhancing data analysis, streamlining research processes, and improving decision-making, ultimately leading to more efficient and effective scientific research and innovation. The findings reveal that while AI can facilitate personalized learning and enhance educational accessibility, it also poses challenges related to academic misconduct, such as plagiarism and the misuse of AI-generated content. This duality highlights the need for educational institutions to develop robust frameworks that leverage AI’s capabilities while safeguarding academic integrity. The article concludes that a collaborative approach, integrating AI into educational practices with a strong emphasis on ethical considerations and integrity, can lead to a synergistic relationship that supports the goals of SDG 4. Recommendations for future research and practical implications for managers, educators, scientists, and policymakers are also discussed, emphasizing the importance of fostering an educational environment that embraces innovation while upholding ethical standards.
Factors Influencing Carbon Emission and Low-Carbon Development Levels in Shandong Province: Method Analysis Based on Improved Random Forest Partial Least Squares Structural Equation Model and Entropy Weight Method
Authors: Zhu Yingjie , Guo Yinghui , Chen Yongfa , Ma Jiageng , Zhang Dan
Published: September 2024

Comprehensively clarifying the influencing factors of carbon emissions is crucial to realizing carbon emission reduction targets in China. To address this issue, this paper develops a four-level carbon emission influencing factor system from six perspectives: population, economy, energy, water resources, main pollutants, and afforestation. To analyze how these factors affect carbon emissions, we propose an improved partial least squares structural equation model (PLS-SEM) based on a random forest (RF), named RF-PLS-SEM. In addition, the entropy weight method (EWM) is employed to evaluate the low-carbon development level according to the results of the RF-PLS-SEM. This paper takes Shandong Province as an example for empirical analysis. The results demonstrate that the improved model significantly improves accuracy from 0.8141 to 0.9220. Moreover, water resources and afforestation have relatively small impacts on carbon emissions. Primary and tertiary industries are negative influencing factors that inhibit the growth of carbon emissions, whereas total energy consumption, the volume of wastewater discharged and of common industrial solid waste are positive and direct influencing factors, and population density is indirect. In particular, this paper explores the important role of fisheries in reducing carbon emissions and discusses the relationship between population aging and carbon emissions. In terms of the level of low-carbon development, the assessment system of carbon emission is constructed from four dimensions, namely, population, economy, energy, and main pollutants, showing weak, basic, and sustainable stages of low-carbon development during the 1997–2012, 2013–2020, and 2021–2022 periods, respectively.
Cityscapes of Hunting and Fishing: Yoruba Place-Making and Cultural Heritage for a Sustainable Urban Vision
Authors: Adedeji Joseph Adeniran , Bigon Liora
Published: September 2024

Literature on African urbanism has generally lacked insight into the significant roles of hunters and fishers as city founders. This has resulted in a knowledge gap regarding the cultural foundation of the cities that could enhance policy frameworks for sustainable urban governance. This article examines corollaries related to the complementarities of hunting and urbanism with case studies from the ethno-linguistic Yoruba region in southwestern Nigeria. Through qualitative methodologies involving ethnography and the (oral) history of landscapes of hunting from the pre-colonial and (British) colonial periods, as well as tracing the current cultural significance of hunting in selected Yoruba cities, the article reveals data that identify hunters and fishers as city founders. It shows that hunting, as a lived heritage, continues to be interlaced with cultural urban practices and Yoruba cosmology and that within this cultural imagery and belief, hunters remain key actors in nature conservation, contributing to socio-cultural capital, economic sustainability, and urban security structures. The article concludes with recommendations for strategies to reconnect with these value systems in rapidly westernizing urban Africa. These reconnections include the re-sacralization of desacralized landscapes of hunting, revival of cultural ideologies, decolonization from occidental conceptions, and re-definition of urbanism and place-making in light of African perspectives despite globalization. In doing so, the article contributes to a deeper understanding of the interconnections between the environmental and societal components of sustainability theory, agenda, and practice in urban contexts; underscores the societal value of lived heritage, cultural heritage, and cultural capital within the growing literature on urban social sustainability; and sheds more light on southern geographies within the social sustainability discourse, a field of study that still disproportionately reflects the global northwest.
Spatio-Temporal Evolution and Implications of Urban Residential Space Based on the New Commercial Housing in Xi’an, China, 2006–2022
Authors: Bai Xiaoying , Wu Wenheng , Liu Limeng , Shang Wanying , Dong Haixia
Published: September 2024

Since 1998, comprehensive housing marketization has led to a more complex urban residential space structure in China, as evidenced by the changes in new commercial housing. The current stage is critical for China in its pursuit of high-quality and sustainable urban development, with the spatial structure of housing being a key aspect in achieving this goal. In order to clarify the characteristics of the urban residential space in China and grasp the spatio-temporal changes of new commercial housing, this study takes the data of new commercial housing projects in Xi’an, northwest China, from 2006 to 2022 as the basis, and uses the GIS method to explore the characteristics of the spatio-temporal evolution of the urban residential space and to investigate the factors influencing it. The results reveal changes in the number, size, and spatial distribution of new commercial housing in Xi’an. The evolution of residential space is influenced by cultural and social changes, population, and economic factors, in addition to the main influence of national policies. The renewal of urban villages into commercial housing projects is a prominent feature of changes in urban residential space, which saves construction land and improves residents’ living conditions. Finally, the expansion of urban residential space parallels the urbanization process, showing a pattern of ‘external expansion accompanied by internal renewal’, and the evolution process and property rights management are different from those of other countries.
External Thermal Insulation Composite Systems—Past and Future in a Sustainable Urban Environment
Authors: Kubečková Darja , Kubenková Kateřina , Afsoosbiria Hamed , Musenda Oskar Kambole , Mohamed Khaled
Published: September 2024

In recent decades, the sustainable development of the planet has been negatively affected by a number of factors, including the construction industry. The construction industry includes, among other things, the highly topical energy reconstruction of existing prefabricated residential housing, which is implemented to improve their condition from a thermal engineering and energy perspective. Composite materials, known as external thermal insulation composite systems (ETICSs), have come to the fore, bringing a number of undeniable benefits to society. After more than 20 years of experience, it turns out that in addition to the benefits, ETICSs also bring new research challenges to the discussion, which are related to the issue of the biocorrosion of the external envelope of ETICSs, and also to the issue of the indoor microclimate. Based on the literature review and case studies, we aim to show that ecologically friendly building materials require a multidisciplinary approach. At the same time, we want to contribute to the discussion of whether the diversity of microorganisms on ETICS composites is a potential source of health risks and whether the transport of microorganisms to the indoor environment can be ruled out through natural ventilation from the outdoor environment to the interior.
The Multi-Parameter Mapping of Groundwater Quality in the Bourgogne-Franche-Comté Region (France) for Spatially Based Monitoring Management
Authors: Bousouis Abderrahim , Bouabdli Abdelhak , Ayach Meryem , Ravung Laurence , Valles Vincent , Barbiero Laurent
Published: September 2024

Groundwater, a vital resource for providing drinking water to populations, must be managed sustainably to ensure its availability and quality. This study aims to assess the groundwater quality in the Bourgogne-Franche-Comté region (~50,000 km2) of France and identify the processes responsible for its variability. Data were extracted from the Sise-Eaux database, resulting in an initial sparse matrix comprising 8723 samples and over 100 bacteriological and physicochemical parameters. From this, a refined full matrix of 3569 samples and 22 key parameters was selected. The data underwent logarithmic transformation before applying principal component analysis (PCA) to reduce the dimensionality of the dataset. The analysis of the spatial structure, using both raw and directional variograms, revealed a categorization of parameters, grouping major ions according to the regional lithology. Bacteriological criteria (Escherichia coli and Enterococcus) displayed strong spatial variability over short distances, whereas iron (Fe) and nitrates showed intermediate spatial characteristics between bacteriology and major ions. The PCA allowed the creation of synthetic maps, with the first seven capturing 80% of the information contained in the database, effectively replacing the individual parameter maps. These synthetic maps highlighted the different processes driving the spatial variations in each quality criterion. On a regional scale, the variations in fecal contamination were found to be multifactorial, with significant influences captured by the first four principal components. The 22 parameters can be grouped into six categories based on their spatial and temporal variations, allowing for the redefinition of a resource management and monitoring strategy that is adapted to the identified spatial patterns and processes at the regional scale, while also reducing analytical costs.
The Integration of Advanced Mechatronic Systems into Industry 4.0 for Smart Manufacturing
Authors: Ryalat Mutaz , Franco Enrico , Elmoaqet Hisham , Almtireen Natheer , Al-Refai Ghaith
Published: September 2024

In recent years, the rapid advancement of digital technologies has driven a profound transformation in both individual lives and business operations. The integration of Industry 4.0 with advanced mechatronic systems is at the forefront of this digital transformation, reshaping the landscape of smart manufacturing. This article explores the convergence of digital technologies and physical systems, with a focus on the critical role of mechatronics in enabling this transformation. Using technologies such as advanced robotics, the Internet of Things (IoT), artificial intelligence (AI), and big data analytics, industries are developing intelligent and interconnected systems capable of real-time data exchange, distributed decision making, and automation. The paper further explores two case studies: one on a smart plastic injection moulding machine and another on soft robots. These examples illustrate the synergies, benefits, challenges, and future potential of integrating mechatronics with Industry 4.0 technologies. Ultimately, this convergence fosters the development of smart factories and products, enhancing manufacturing efficiency, adaptability, and productivity, while also contributing to sustainability by reducing waste, optimising resource usage, and lowering the environmental impact of industrial production. This marks a significant shift in industrial production towards more sustainable practices.
Aspects of Spodumene Lithium Extraction Techniques
Authors: Nandihalli Nagaraj , Chouhan Rajiv K. , Kuchi Rambabu , Hlova Ihor Z.
Published: September 2024

Lithium (Li), a leading cathode material in rechargeable Li-ion batteries, is vital to modern energy storage technology, establishing it as one of the most impactful and strategical elements. Given the surge in the electric car market, it is crucial to improve lithium recovery from its rich mineral deposits using the most effective extraction technique. In recent years, both industry and academia have shown significant interest in Li recovery from various Li-bearing minerals. Of these, only extraction from spodumene has established a reliable industrial production of Li salts. The current approaches for cracking of the naturally occurring, stable α-spodumene structure into a more open structure—β-spodumene—involve the so-called decrepitation process that takes place at extreme temperatures of ~1100 °C. This conversion is necessary, as β-spodumene is more susceptible to chemical attacks facilitating Li extraction. In the last several decades, many techniques have been demonstrated and patented to process hard-rock mineral spodumene. The objective of this review is to present a thorough analysis of significant findings and the enhancement of process flowsheets over time that can be useful for both research endeavors and industrial process improvements. The review focuses on the following techniques: acid methods, alkali methods, carbonate roasting/autoclaving methods, sulfuric acid roasting/autoclaving methods, chlorinating methods, and mechanochemical activation. Recently, microwaves (MWs), as an energy source, have been employed to transform α-spodumene into β-spodumene. Considering its energy-efficient and short-duration aspects, the review discusses the interaction mechanism of MWs with solids, MW-assisted decrepitation, and Li extraction efficiencies. Finally, the merits and/or disadvantages, challenges, and prospects of the processes are summarized.
Effectiveness of Virtual Reality in Healthcare Education: Systematic Review and Meta-Analysis
Authors: Sung Hyunkyung , Kim Mikyung , Park Jangkyung , Shin Namin , Han Yejin
Published: September 2024

As technology advances, virtual reality (VR) is increasingly being integrated into healthcare education to enhance learning outcomes. This systematic literature review and meta-analysis examined the effectiveness of virtual reality-based healthcare education. Randomized controlled trials (RCTs) published over the past 10 years were retrieved from 10 databases using VR, healthcare, and education as the primary keywords. Following the inclusion and exclusion criteria, 45 studies were included in the final analysis. A meta-analysis was performed to analyze the effects of VR in terms of knowledge, skill, and attitude. The results revealed that the use of VR significantly improved the knowledge (SMD: 0.28, 95% CI: 0.18–0.39, p < 0.001) and skill scores (SMD: 0.23, 95% CI: 0.11–0.34, p < 0.001), shortened the skill performance time (SMD: −0.59, 95% CI: −0.82 to −0.35, p < 0.001), and improved the satisfaction (SMD: 0.65, 95% CI: 0.48–0.81, p < 0.001) and confidence levels (SMD: 0.60, 95% CI: 0.41–0.80, p < 0.001). The in-depth analysis highlighted the significant potential of VR and provided practical implications in educational settings. In conclusion, effectively integrating VR with traditional educational methods is necessary to enhance both the quality of learning and the overall competence of healthcare professionals.
Salt Tolerance of Phragmites australis and Effect of Combing It with Topsoil Filters on Biofiltration of CaCl2 Contaminated Soil
Authors: Ju Jin-Hee
Published: September 2024

De-icing salt used for safe winter driving can have negative impacts on local water quality, vegetation, and soils. This study aimed to evaluate the salt tolerance of reeds (Phragmites australis) against calcium chloride (CaCl2) and the biofiltration effect of combining it with topsoil biofilters for desalination in roadside ditches. Two experiments were conducted in a controlled environmental greenhouse over a period of 150 days. For the first experiment, the salt tolerance of P. australis was examined after treating reeds with five different concentrations of de-icing salt: 0, 1, 2, 5, and 10 g·L−1. In a second experiment, the effect of combining two topsoil filters (expanded clay and activated carbon), each planted with and without reeds, was investigated under a high CaCl2 concentration of 10 g·L−1. As the CaCl2 concentration increased, the electrical conductivity (EC) of soil leachate and the level of salt exchangeable cations (K+, Ca2+, Na+, and Mg2+) significantly increased whereas the acidity (pH) significantly decreased (all p ≤ 0.05). No statistical difference was observed in leaf length or width, while plant height, number of leaves, and both fresh and dry weights were significantly increased with increasing CaCl2 concentrations (p ≤ 0.05). Treatments using topsoil filters, particularly those with activated carbon and reeds, showed the greatest reduction in leachate EC and total exchange cations values. These results suggest that combining P. australis with topsoil filters can assist biofiltration effectively, demonstrating its applicability even in roadside soils subject to extreme levels of de-icing salts.
Participatory Mapping of Ethnoecological Perspectives on Land Degradation Neutrality in Southern Burkina Faso
Authors: Ilboudo Nébié Elisabeth Kago , West Colin Thor
Published: September 2024

In the Sahel region of West Africa, land degradation has raised concerns about the threat of desertification, leading to the establishment of the United Nations Convention to Combat Desertification (UNCCD) in 1994. Over time, the focus has shifted from simply combating desertification to a more comprehensive international program focused on preserving the health of our land by offsetting any damage with restoration efforts by 2030 to sustain ecosystem functions and services. This balancing process—which is in line with the Sustainable Development Goals (SDGs)—is known as Land Degradation Neutrality (LDN). We examine Land Degradation Neutrality (LDN) patterns, namely degradation and rehabilitation processes, by integrating participatory mapping with high-resolution satellite imagery with local stories, observations, historical records, and existing studies. The data elicited an understanding of the processes driving land degradation and adaptation strategies among three distinct ethnic groups of crop and livestock farmers in the village of Yallé in southern Burkina Faso. Some of these people were originally from this region, while others moved from places where the land was already degraded. Participants in the study had diverse experiences and perceptions of land degradation, its drivers, and adaptation strategies, which were influenced by their ethnicity, livelihood activities, and life experiences. These differences highlight the impact of cultural and socioeconomic factors on how people view land degradation, as well as the role of local knowledge in managing the environment. The study emphasizes the necessity of incorporating ethnoecological perspectives into projects focused on Land Degradation Neutrality (LDN) to better understand land degradation and improve land management. This integration can significantly contribute to strengthening global sustainability and community resilience.
Adoption Intention of Blockchain Technologies for Sustainable Supply Chain Management in Indian MSMEs
Authors: Paliwal Vineet , Chandra Shalini , Sharma Suneel
Published: September 2024

This study explores the determinants of the intention to adopt blockchain technology for sustainable supply chain management in Indian micro, small, and medium enterprises. Different from existing studies that advocate the use of socio-technical theory for blockchain technologies, we develop a new theoretical framework, called “SOS,” based on a review of the existing literature. This is an adaptation of the technology–organization–environment framework that examines the measures and scales from socio-technical, organizational, and sustainability contexts. We use ADANCO 2.3.2 for variance-based structural equation modeling. The results show that two of the nine hypotheses are negatively significant, while the rest are positive. In our context, social sustainability and computer self-efficacy are strongly negatively significant for the adoption intention of blockchain technology in our context. Software quality and environmental sustainability are strongly positively significant. Meanwhile, collaboration, economic sustainability, and relative advantage mediated by experience are positively significant. Our study contributes to the literature by offering a new theoretical framework, fresh insights from the Indian industry, and several recommendations to practitioners.
Financial Inclusion and Poverty Alleviation: A Critical Analysis in Nigeria
Authors: Omenihu Chinonyerem Matilda , Brahma Sanjukta , Katsikas Epameinondas , Vrontis Demetris , Siachou Evangelia , Krasonikolakis Ioannis
Published: September 2024

The study looks at the impact that the three dimensions of financial inclusion (FI) (i.e., access, usage, quality) may have on poverty alleviation. In doing so, the study relies on demand and supply-side data to measure Nigeria’s FI. The demand-side data were derived from the 2021 Global Findex data, and the supply side data were sourced from the IMF Access survey database (2004–2021). The supply-side data were analysed using the ordinary least squares regression (OLS), while the demand-side data were analysed using the probit regression model. The study outcomes revealed a negative and significant relationship between financial access and poverty rate, further indicating that those who use financial services are less likely to experience poverty. The study recommends that financial service providers tailor their financial products to align with the educational level of the target population to encourage savings.
Erbil Citadel as a Brand for the City, the Role of Residents Awareness and Perceptions
Authors: Ali Haval Sami , Khayat Mahmood
Published: September 2024

The branding of cities through their historical and cultural assets has become a pivotal strategy in urban development and tourism. This study focuses on Erbil Citadel, a UNESCO World Heritage Site, and its potential as a brand for Erbil, a city with a rich historical backdrop and flourishing urban landscape. The study aimed to explore the perceptions of Erbil’s residents regarding the cultural significance of the Citadel and its potential as a city brand. A mixed-method survey questionnaire was conducted, collecting data from around 440 residents through both manual distribution around the Citadel and an online platform. The findings were analyzed using SPSS 23 to provide both descriptive and inferential statistical insights. The findings show that locals are well aware of the Citadel’s significance as a significant historical and cultural symbol of the city. The vast majority of participants acknowledged its unique visual attributes and their representation of the city’s cultural and historical identity. Additionally, the results showed that citizens’ perceptions of the Citadel as a good component of city branding were positively correlated with their level of cultural awareness. This study contributes to the growing body of literature on city branding and heritage sites by providing empirical evidence on the impact of residents’ cultural awareness on their perceptions of heritage sites as city brands. The results highlight how crucial cultural education and community involvement are to maximizing the branding potential of historic locations. Policymakers and urban planners may find the findings of the study useful in utilizing Erbil Citadel’s historical relevance to strengthen Erbil’s brand identity internationally.
Sustainability Performance Reporting
Authors: Rusu Teodora Maria , Odagiu Antonia , Pop Horia , Paulette Laura
Published: September 2024

Sustainability reporting is an essential tool for companies and organizations to assess and communicate their sustainability performance. Its importance derives from the need for transparency and accountability to stakeholders, including investors, customers, employees and local communities. The principles underlying an effective sustainability report include integrity, accuracy, comparability and clarity. The main purpose of the sustainability report is to provide a clear view of the economic, social and environmental impact of the organization’s activities, contributing to continuous performance improvement and alignment with international standards. The objective of our study is to analyze sustainability reporting and ESG (environment, social, governance) reporting, key steps and methods for measuring and reporting sustainability, and the sustainability policy criteria and reporting frameworks used internationally (GRI, IIRC, SASB, TCFD, ISO 26000, ISO 14016) in order to identify areas for further development to improve the relevance and effectiveness of sustainability reporting. The results obtained from our study enable a better understanding of how an organization reports its social, economic, and environmental impact, the differences in compliance with the international standards used, the main steps, and sustainability criteria followed. Our research highlights the necessary actions and steps through which sustainability reporting can become a more effective and relevant tool, contributing to real sustainable development and more responsible resource management. The usefulness of this report is reflected in many aspects: it facilitates informed decision making, enhances trust and reputation, helps identify risks and opportunities, and supports sustainable business strategies. The sustainability report is not only a means of reporting but also a catalyst for positive change, promoting responsible business practices and contributing to global sustainable development.
Research on the Impact Mechanism and Empirical Study of the Digital Economy on Rural Revitalization in the Yangtze River Economic Belt
Authors: Zhang Xulu , Qi Feng , Cao Xinxin
Published: September 2024

As a new engine of China’s economic development, the digital economy is playing an important role in rural revitalization. Due to the impact of the novel coronavirus epidemic, there is a lack of recent empirical research on the digital economy and rural revitalization and development of the Yangtze River Economic Belt. Based on the provincial panel data of 11 provinces in the Yangtze River Economic Belt from 2014 to 2022, this paper calculates the comprehensive development level of the digital economy and rural revitalization and conducts a benchmark regression on their relationship. The results of the heterogeneity analysis show that the impact of the digital economy on rural revitalization in the upper and middle reaches of the Yangtze River is stronger than that in the lower reaches. Then we adopt the Moran index and spatial Durbin model for further regression analysis, and find that there is a spatial autocorrelation between the digital economy and rural revitalization. The digital economy of the Yangtze River Economic Belt has a spatial spillover effect on rural revitalization. To effectively harness the digital economy’s role in advancing rural revitalization, it is crucial to tailor resource allocation to local conditions, implement targeted policies, and establish a robust monitoring and evaluation system. This strategy aims to facilitate the seamless integration of the digital economy with rural revitalization, thereby achieving synergistic effects and promoting comprehensive, sustainable development in both economic and social dimensions.
SYNCHRONIZE: Real-World Retrospective Safety Analysis of Patients Treated with OnabotulinumtoxinA for More than One Therapeutic Indication
Authors: Forde Grace , Brucker Benjamin M. , Becker Ifantides Kimberly , Patel Atul T. , Mayadev Angeli , Brown Theodore , Ayyoub Ziyad , Martinez Kenneth , Singh Ritu , Nelson Mariana , Battucci Simona , Yushmanova Irina , Ukah Ahunna , Rhyne Christopher
Published: September 2024

OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the safety of onabotA when treating multiple indications concomitantly. SYNCHRONIZE was a multicenter, retrospective, chart-review study evaluating onabotA’s safety for adults treated for ≥2 therapeutic indications within a 3-month period. The primary outcome was treatment-emergent adverse events (TEAEs) within 6 months post-treatment. A total of 279 patients were included. The most common concomitant indications treated were cervical dystonia and chronic migraine (43.4%). The average 3-month cumulative dose for multiple indications was 282.2 U. The treatment interval for multiple indications was ≤24 h for most patients (62.4%). Overall, 28.7% of patients reported ≥1 TEAE with no apparent trends in TEAEs and dose interval or cumulative dose. Reported TEAEs included UTI (5.7%), neck pain (5.0%), and headache (4.3%). No patient had a lack of effect according to clinical objective measurements. SYNCHRONIZE described the real-world safety of onabotA for patients treated concomitantly for ≥2 indications within a 3-month period. TEAEs were generally consistent with the known safety profiles of individual indications. No new safety signals were identified).
Bovine Transcription Factor POU Class 2 Homeobox 1 (POU2F1/Oct1) Protein Promotes BoHV-1 Replication in MDBK Cells
Authors: Rong Enguang , Dry Inga , Dalziel Robert G. , Tan Wenfang Spring
Published: September 2024

Bovine herpesvirus type 1 (BoHV-1) causes severe diseases in bovine species and great economic burden to the cattle industry worldwide. Due to its complex life cycle, many host factors that affect BoHV-1 replication remain to be explored. To understand the possible roles that the Oct1 cellular protein could play in this process, we first created Oct1-deficient MDBK cells using CRISPR/Cas9-mediated genome editing. Upon infection, the absence of Oct1 in MDBK cells significantly impacted BoHV-1 replication, a phenotype rescued by over-expressing the wild-type Oct1 protein in the deficient cells. We further found that the expression of all three classes of temporal genes, including essential and non-essential viral genes, were significantly reduced in Oct1 knockout MDBK cells, following both high and low multiplicity of infection. In summary, our findings confirm that the bovine Oct1 protein acts as a pro-viral factor for BoHV-1 replication by promoting its viral gene transcription in MDBK cells.
Intrauterine Fetal Demise, Spontaneous Abortion and Congenital Cytomegalovirus: A Systematic Review of the Incidence and Histopathologic Features
Authors: Pesch Megan H. , Mowers Jonathan , Huynh Anh , Schleiss Mark R.
Published: September 2024

The objective was to review the existing literature reporting on spontaneous abortion (SA) and intrauterine fetal demise (IUFD) associated with cytomegalovirus (CMV) infection. A review using standardized terminology such as ‘intrauterine fetal death’, ‘congenital cytomegalovirus’ and ‘CMV’ was performed using PubMed and Embase (Medline) using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Twenty-one studies met inclusion criteria. CMV was identified as a potential or likely factor in a median of 7.1% of SA or IUFD in study cohorts. Of the studies, 11 used fetal remains, 18 used placenta, 6 used serum, and 1 used post-mortem dried blood spot as specimens for testing for CMV. Features commonly observed were fetal thrombotic vasculopathy, hydrops fetalis and chronic villitis. CMV is frequently noted in studies evaluating viral etiologies of SA or IUFD. Large population-based studies are needed to estimate the incidence of CMV-associated SA or IUFD. CMV and congenital CMV should be included on the differential diagnosis in all cases of SA or IUFD of unknown etiology.
Discriminating North American Swine Influenza Viruses with a Portable, One-Step, Triplex Real-Time RT-PCR Assay, and Portable Sequencing
Authors: Kirby Marie K. , Shu Bo , Keller Matthew W. , Wilson Malania M. , Rambo-Martin Benjamin L. , Jang Yunho , Liddell Jimma , Salinas Duron Eduardo , Nolting Jacqueline M. , Bowman Andrew S. , Davis C. Todd , Wentworth David E. , Barnes John R.
Published: September 2024

Swine harbors a genetically diverse population of swine influenza A viruses (IAV-S), with demonstrated potential to transmit to the human population, causing outbreaks and pandemics. Here, we describe the development of a one-step, triplex real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay that detects and distinguishes the majority of the antigenically distinct influenza A virus hemagglutinin (HA) clades currently circulating in North American swine, including the IAV-S H1 1A.1 (α), 1A.2 (β), 1A.3 (γ), 1B.2.2 (δ1) and 1B.2.1 (δ2) clades, and the IAV-S H3 2010.1 clade. We performed an in-field test at an exhibition swine show using in-field viral concentration and RNA extraction methodologies and a portable real-time PCR instrument, and rapidly identified three distinct IAV-S clades circulating within the N.A. swine population. Portable sequencing is used to further confirm the results of the in-field test of the swine triplex assay. The IAV-S triplex rRT-PCR assay can be easily transported and used in-field to characterize circulating IAV-S clades in North America, allowing for surveillance and early detection of North American IAV-S with human outbreak and pandemic potential.
Cost-Effectiveness of Influenza Vaccination in Healthy Children: A 10-Year Population-Based Study
Authors: Barbieri Elisa , Wang Yuxi , Cantarutti Anna , Scamarcia Antonio , Cantarutti Luigi , Corrao Giovanni , Torbica Aleksandra , Giaquinto Carlo
Published: September 2024

Background/Objectives: Seasonal influenza annually puts a significant burden on the pediatric population, especially the youngest, causing severe illness and death. Additionally, associated healthcare costs cause a significant financial strain on healthcare systems. While vaccination is the most effective prevention method, its cost-effectiveness for healthy children remains unassessed. Methods: Using the Pedianet database spanning from 2009 to 2019, we analyzed influenza cases among 6-month-olds to 14-year-olds in Italy. Data included influenza-related medical visits, prescriptions, exams, emergency visits, hospitalizations, and costs. Adverse events and quality-adjusted life years (QALYs) were considered from the existing literature. A static decision-tree model compared annual vaccination strategies, assessing probabilities for influenza or influenza-like illnesses by vaccination status. Incremental cost-effectiveness ratios (ICERs) were calculated, along with sensitivity analyses and cost-effectiveness acceptability curve generation. Results: Mean total influenza costs for vaccinated children averaged EUR 18.6 (range 0–3175.9, including EUR 15.79 for the influenza vaccination), whereas costs for unvaccinated children were consistently lower at around EUR 4.6 (range 0–3250.1). The average ICER for years where vaccine and virus strains are matched was EUR 29,831 per QALY, which is below the EUR 40,000 threshold set by the Italian National Health Services. The ICER values range from EUR 13,736 (2017/2018) to EUR 72,153 (2013/2014). Averted influenza costs averaged EUR 23 per case, with fluctuations over the years. In most observed years, influenza vaccination was cost-effective from the healthcare providers’ standpoint. The exception was 2009–2010, due to a mismatch between vaccine and virus strains. Conclusions: This study highlights the economic viability of influenza vaccination, especially when virus and vaccine strains align. It demonstrates the potential of vaccination programs in preserving children’s health and well-being while managing healthcare costs.
Detection of PCV2d in Vaccinated Pigs in Colombia and Prediction of Vaccine T Cell Epitope Coverage against Circulating Strains Using EpiCC Analysis
Authors: Vargas-Bermudez Diana S. , Gil-Silva Alixs Constanza , Naranjo-Ortíz María F. , Mogollón José Darío , Gómez-Betancur Jair F. , Estrada José F. , Aldaz Álvaro , Garzón-González Harold , Angulo José , Foss Dennis , Gutierrez Andres H. , Jaime Jairo
Published: September 2024

Porcine circovirus type 2 (PCV2) is strongly linked to a group of syndromes referred to as porcine-circovirus-associated diseases (PCVADs), which are controlled through vaccination; however, this does not induce sterilizing immunity but is instead involved in the evolution of the virus and is considered a factor in vaccine failure. This study sampled 84 herds (167 pigs) vaccinated against PCV2 and with clinical signs of PCVADs in five provinces across Colombia. PCV2 was identified and further characterized at the molecular level via genotyping and phylogenetic reconstructions. In addition, PCV2-associated lesions were examined via histopathology. Furthermore, the PCV2-Cap sequences retrieved were compared with three vaccines via the EpiCC tool and T cell epitope coverage. The prevalence of PCV2 was 82% in pigs and 92.9% in herds. The highest viral loads were identified in lymphoid tissue, and PCV2d emerged as the most predominant in pigs and herds (93.4% and 92.3%). Sequences for PCV2-ORF2 (n = 57; 55 PCV2d and 2 PCV2a) were determined, and PCV2d sequences were highly similar. The most common pneumonia pattern was suppurative bronchopneumonia, while the most common lung lesion was exudation in the airways; in lymphoid tissue, there was lymphoid depletion. The bivalent vaccine (PCV2a and PCVb) exhibited a higher EpiCC score (8.36) and T cell epitope coverage (80.6%) than monovalent PCV2a vaccines. In conclusion, PCV2d currently circulates widely in Colombia. Despite vaccination, there are clinical cases of PCV2, and immunoinformatic analyses demonstrate that bivalent vaccines improved the average coverage.
Groundwater Quality and Human Health Risk
Authors: Alexakis Dimitrios E.
Published: September 2024

Access to potable water is one of the most significant challenges that humanity will have to deal with in the years to come [...]
Future Projection of Water Resources of Ruzizi River Basin: What Are the Challenges for Management Strategy?
Authors: Ahana Bayongwa Samuel , Nguyen Binh Quang , Posite Vithundwa Richard , Abdelbaki Cherifa , Kantoush Sameh Ahmed
Published: September 2024

This study investigates the impact of climate change on hydrological dynamics in the Ruzizi River Basin (RRB) by leveraging a combination of observational historical data and downscaled climate model outputs. The primary objective is to evaluate changes in precipitation, temperature, and water balance components under different climate scenarios. We employed a multi-modal ensemble (MME) approach to enhance the accuracy of climate projections, integrating historical climate data spanning from 1950 to 2014 with downscaled projections for the SSP2-4.5 and SSP5-8.5 scenarios, covering future periods from 2040 to 2100. Our methodology involved calibrating and validating the SWAT model against observed hydrological data to ensure reliable simulations of future climate scenarios. The model’s performance was assessed using metrics such as R2, NSE, KGE, and PBIAS, which closely aligned with recommended standards. Results reveal a significant decline in mean annual precipitation, with reductions of up to 37.86% by mid-century under the SSP5-8.5 scenario. This decline is projected to lead to substantial reductions in surface runoff, evapotranspiration, and water yield, alongside a marked decrease in mean monthly stream flow, critically impacting agricultural, domestic, and ecological water needs. The study underscores the necessity of adaptive water resource management strategies to address these anticipated changes. Key recommendations include implementing a dynamic reservoir operation system, enhancing forecasting tools, and incorporating green infrastructure to maintain water quality, support ecosystem resilience, and ensure sustainable water use in the RRB. This research emphasizes the need for localized strategies to address climate-driven hydrological changes and protect future water resources.
Towards Hydraulic Design Optimization of Shaft Hydropower Plants: A 3D-CFD Application Based on Physical Models
Authors: Alapfy Bertalan , Gamarra Nicolas Francisco , Rüther Nils
Published: September 2024

The shaft hydropower plant (SHPP) is a novel hydraulic concept for low-head hydropower sites with several environmental and operational advantages over conventional layouts. However, the first two projects implementing this concept have shown comparatively high construction costs and project risks. Therefore, further optimization is required to increase economic attractiveness and enable broader market adoption. Initial model tests recommend a square-shaped shaft inlet with a three-sided approach flow for low-loss and fish-friendly inflow conditions. Yet, this design requires significant space for structural implementation and may be unsuitable for use with multiple shafts or as an extension of non-powered dams and weirs. This research paper presents the application of a computational fluid dynamics simulation setup to evaluate the hydraulic performance of various design configurations, especially alternative design layouts with a one-sided approach flow without further physical model tests. The simulation setup is calibrated against observations including head loss and velocity measurements from the physical model tests, and its satisfactory performance enables the analysis of alternative design layouts. This study aims to derive the most significant design parameters for achieving the desired hydraulic conditions at the intake. Increasing the flow depth before the intake and enlarging the inlet area have the most significant impact, while increasing the overflow of the front gate has the least significant effect. The chosen CFD application is deemed suitable for hydraulic design optimization and provides guidance on the key parameters to focus on for tailored site-specific design development.
Numerical Simulation Study of an Artificial Percolation Riverbed and Its Hydraulic Characteristics under Different Reynolds Numbers
Authors: Yang Ming , Li Yongye , Sun Xihuan , Wang Lianle
Published: September 2024

The direct extraction of clear water from a sandy river is a difficult task and can only be achieved through specific engineering measures. This paper proposes an artificial percolation riverbed structure for extracting clean water from sandy rivers, using a numerical simulation to study the flow field distribution characteristics of the structure under clean water conditions. The main conclusions are as follows: When the percolation vortex tube opening rate is 1.4%, the vortex tube with or without opening the percolation hole has little influence on the distribution characteristics of the flow field in the artificial riverbed, and the purpose of water extraction can be achieved while constructing a helical flow field. The axial flow velocity and circumferential flow velocity of the vortex tube cross-section under different Reynolds numbers show the distribution of a low-flow velocity close to the center of the vortex tube, and a high-flow velocity close to the vortex tube side-wall area. The average axial flow velocity and average circumferential flow velocity of the vortex tube show a trend of increasing and then decreasing distribution along the axial axis of the vortex tube in the direction of the sediment transport flume. The mean axial flow velocity of the vortex tube along the axis of the vortex tube toward the sediment transport flume and the mean circumferential flow velocity both show a distribution trend of increasing and then decreasing. At the junction of the vortex tube and the sediment transport flume, there are obvious pressure changes, and the pressure changes drastically under the same horizontal line. Along the direction of the bottom line of the vortex tube, the pressure at the vortex tube is obviously greater than that at the sediment transport flume. The vortex of the artificial percolation riverbed is mainly concentrated in the vicinity of the vortex tube, and the maximum value of the vortex intensity generally occurs at the junction of the vortex tube and the sediment transport flume. With the increase in the Reynolds number, the vortex intensity has an overall increasing trend, and the distribution of the vortex is more complex. This study helps to elucidate the distribution characteristics of the flow field in the artificial percolation riverbed, and it provides a reference basis for the future study of the flow field of artificial percolation riverbeds of sandy rivers.
OS USOS DO ALIMENTO ENQUANTO OFERENDA NO BUTSUDAN ENTRE PRATICANTES NO BRASIL
Authors: Meira de Oliveira Rafael
Published: September 2024

Esse artigo tem o objetivo de apresentar uma síntese do que foi minha pesquisa na graduação, trazendo a discussão proposta e as considerações finais do trabalho: analisar, a partir de fontes audiovisuais, como tem sido utilizado o alimento como oferenda no butsudan (oratório doméstico de caráter budista) entre adeptos budistas, de 2016 a 2019. Sobre o conteúdo audiovisual, será analisada a estética e os aspectos que dizem respeito à construção da mensagem apresentada. Espera-se, como resultados, sugerir que houve diversas modificações no que se considerou comida/oferenda aos ancestrais ao longo do tempo, indicando o processo de mudanças e ressignificações do Budismo japonês no Brasil.