bluuebunny/crossref_metadata_2025 huggingface dataset:
ФОРМУВАННЯ ТВОРЧО СПРЯМОВАНОЇ ОСОБИСТОСТІ СТАРШОГО ДОШКІЛЬНИКА В ОСВІТНЬОМУ СЕРЕДОВИЩІ ЗАКЛАДУ ПОЗАШКІЛЬНОЇ ОСВІТИ
Authors: АЛЕНДАРЬ Надія , СЕМЕНОВ Олександр , СЕМЕНОВА Наталія
Published: February 2025

У статті розглядається актуальна проблема формування творчо спрямованої особистості старшого дошкільника в умовах закладу позашкільної освіти. В умовах реформування системи освіти та соціально-політичних змін, що відбуваються в Україні, позашкільні заклади освіти відіграють важливу роль у формуванні нової генерації творчих, рефлексивно мислячих особистостей. Автори аналізують змістові характеристики освітнього середовища закладу позашкільної освіти, які сприяють розвитку творчих здібностей дітей. Вони виділяють такі специфічні якісні характеристики освітнього середовища, як соціально-педагогічна актуальність, особистісна зацікавленість, індивідуалізованість, автентичність, гетерогенність, цільова та змістова варіативність, відкритість до педагогічних інновацій, практико орієнтована процесуальність та креативність. У статті також розглядаються різні аспекти впливу освітнього середовища на розвиток дитини, зокрема, когнітивно-оцінковий, поведінково-діяльнісний, емоційно-чуттєвий та комунікативний компоненти. Автори підкреслюють важливість суб’єкт-суб’єктної взаємодії між дитиною та дорослим, що сприяє розвитку творчих здібностей та самореалізації особистості. На основі проведеного теоретико-методологічного аналізу автори розробили комплексну технологію засвоєння освітнього простору, яка включає когнітивно-оцінковий, поведінково-діяльнісний, емоційно-чуттєвий та комунікативний компоненти. Ця технологія спрямована на актуалізацію потреби старшого дошкільника у творчій активності та забезпечення умов для його особистісного, професійного та соціокультурного самовизначення. Висновки статті підкреслюють, що освітнє середовище закладу позашкільної освіти є найбільш сприятливим для розвитку творчо спрямованої особистості дитини старшого дошкільного віку. Наголошується на необхідності створення структурно-функціональної моделі формування творчо спрямованої особистості в умовах позашкільної освіти.
ПЕДАГОГІЧНІ УМОВИ ЕФЕКТИВНОГО ПЕДАГОГІЧНОГО ПАРТНЕРСТВА ТА КОМУНІКАЦІЇ В ПРОФЕСІЙНІЙ ДІЯЛЬНОСТІ ВИХОВАТЕЛЯ ЗАКЛАДУ ДОШКІЛЬНОЇ ОСВІТИ
Authors: СУЯТИНОВА Катерина
Published: February 2025

Актуальність дослідження зумовлена зростаючою роллю педагогічного партнерства в контексті сучасної дошкільної освіти. Ефективна комунікація та співпраця між усіма учасниками освітнього процесу – вихователями, дітьми та батьками – є ключовим фактором успішного розвитку дитини. Мета дослідження – теоретично обґрунтувати основні поняття теми, визначити педагогічні умови, які сприяють ефективному педагогічному партнерству та комунікації в професійній діяльності вихователя закладу дошкільної освіти. Глобалізація, інформатизація, динаміка соціальних процесів створюють нові виклики для виховання дітей дошкільного віку. Зміна ролей батьків, зростання кількості працюючих матерів, розширення можливостей дошкільної освіти – все це впливає на характер взаємодії сім'ї та закладу дошкільної освіти. Успішність дошкільної освіти залежить від ефективної взаємодії всіх учасників освітнього процесу: вихователів, дітей та батьків. Сучасні діти потребують різноманітних стимулів для розвитку, що вимагає від вихователів постійного оновлення своїх знань і вмінь. Ефективна комунікація та співпраця між усіма учасниками освітнього процесу сприяє створенню комфортного середовища для розвитку дітей. Актуальність дослідження підтверджується також відсутністю достатнього числа наукових робіт, присвячених саме педагогічним умовам ефективного педагогічного партнерства та комунікації в професійній діяльності вихователя закладу дошкільної освіти в контексті сучасних викликів. На нашу думку, запропоновані педагогічні умови сприятимуть ефективному педагогічному партнерству та комунікації в професійній діяльності вихователя закладу дошкільної освіти, а саме: професійна готовність вихователя до гуманізації освітнього середовища; здатність вихователів закладів дошкільної освіти до комунікативної мобільності; емоційно-ціннісне ставлення до всіх учасників освітнього процесу; створення розвивального мовленнєвого середовища; стимулювання партнерів до рефлексивної діяльності. Перспективами подальшого розвитку є створення елективного курсу для студентів другого (магістерського) рівня вищої освіти спеціальності 012 Дошкільна освіта.
МОДЕРНІЗАЦІЯ ЗМІСТУ ШКІЛЬНОЇ МАТЕМАТИЧНОЇ ОСВІТИ У ВИМІРАХ НУШ
Authors: СКОРОЛІТНЯ Аліна
Published: February 2025

У статті розглядається процес модернізації змісту шкільної математичної освіти в контексті Нової української школи. Наведено основнi принципи осучаснення освiти, висвiтлено особливостi концептуальних засад реформування середньої школи «Нова українська школа». Окреслено мету сучасної математичної освіти та місце математики у системі шкільної освіти. А також визначено напрями, за якими учні опановують базові знання математичної освітньої галузі згідно з Державним стандартом базової середньої освіти, та які вміння, навички школярі засвоять на основі отриманих знань. Деталізовано, як згідно Державного стандарту розшифровуються індекси обов’язкових результатів навчання учнів. Розглянуто орієнтири для оцінювання результатів навчання учнів, наведено та охарактеризовано 4 групи споріднених результатів навчання у математичній освітній галузі згідно з Держстандартом. Кожна з цих груп спрямована на розвиток різних аспектів математичної компетентності учнів. Це допомагає не тільки систематизувати процес навчання, але й забезпечити індивідуальний підхід до кожного учня, орієнтуючи навчання на практичне застосування знань, розвиток логічного й критичного мислення, а також готовність до вирішення проблем у житті та професійній діяльності. У статті зазначається, що модернізація змісту шкільної математичної освіти в контексті НУШ передбачає комплексний підхід, що у свою чергу охоплює не лише зміни у самому навчальному процесі, але й у підходах до навчання, оцінювання, а також професійного розвитку вчителів.
The Role of English Teachers in the Digital Age: A Closer Look
Authors: Mohammad Jalaluddin
Published: February 2025

There was a time when students were mainly dependent on the teacher and learning and teaching were limited to the classroom. The role of the teacher was considered crucial, but now, in the digital age, the role of the teacher has changed. In the days before the digital age, a highly motivated student would listen to BBC News, watch English movies and buy English newspapers and books. But in the 21st century, it is not just about the classroom, notebooks and textbook. After the invention of the internet and digital media, English learning and teaching have entered a new era. We thank technology for providing us with great opportunities to ignite interest in students and motivate them. As an English teacher, we should change our attitude from traditional methods to modern methods and use modern educational technology. The article discusses the importance of digital tools in English teacher education and the need for effective and appropriate management of technology. It explores the knowledge and skills that English language teachers need to possess in the digital era, including their roles in using digital tools and developing their competence in the hypermedia environment. This is fundamental to effective teaching and approaches to language teacher education.
Creative Care: Artistic Action in the Stop Cop City Movement
Authors: Borden Ivy
Published: February 2025

The Weelaunee Forest, also known as the South River or Atlanta Forest, is currently receiving national attention as protestors from the Stop Cop City (SCC) movement attempt to protect the land from being cleared for the development of a large-scale police training facility. Relying on a combination of existing scholarly literature, recent news articles, and two personally collected interviews, my research investigates the role of artistic and creative forms of activism, resistance, and community support in SCC movement. I apply ethics of care to this research by focusing on the ways artistic activism encourages multiplicity of perspectives, responds to psychological needs, and facilitates alternative forms of communication that bridge distances of difference. Ultimately, this paper advocates for the irreplaceable importance of creative expression and artistic meaning making in local efforts to resist cycles of institutionalized oppression.
Impact of regular whole-blood donation on hemoglobin level
Authors: Hartini Supri , Sukarya I Gede Andika , Fortuna Malika Sasi Fitria
Published: February 2025

Background: Blood donation is regarded as a noble, voluntary act that is done without compensation. Prior to donation, donors undergo a preliminary examination (including blood pressure, blood type, hemoglobin levels, pulse, etc.). After donating blood, it is important to recheck their hemoglobin levels to determine whether they are low or remain stable.
Purpose: To determine the impact of regular whole blood donation on hemoglobin levels.
Method: A descriptive study with an observational design. The variable is the hemoglobin level before and after blood donation. The research was conducted at the Indonesian Red Cross Society of Tenggarong, with 45 blood donors as respondents. Hemoglobin levels were measured using a POCT (Point of Care Testing) tool. Data analysis was performed univariately to assess the hemoglobin level changes before and after donation.
Results: The study revealed gender characteristics for male and female donors, with an average Hb level of 14.5 gr/dl for men and 13.25 gr/dl for women in their last donation. For current donation, the average Hb levels were 14 gr/dl for men and 11.65 gr/dl for women. The decrease in hemoglobin levels was 0.5 gr/dl for men and 1.6 gr/dl for women. Almost all donors showed no symptoms post-donation.
Conclusion: Hemoglobin levels decreased after donation, but there were no symptoms such as fainting for both men and women.
Suggestion: Donors can use this information to increase their understanding of hemoglobin levels, ensure they get adequate rest the night before donation, eat iron-rich foods, and avoid strenuous activities after donating blood. It is also recommended that future researchers consider including the menstrual cycle as a factor in similar studies.
Investigación formativa en diseño de moda. Un poco de magia. PISE 2022-1
Authors: Riachi Vega Clara Ivonne
Published: February 2025

La guía de trabajo 2022-1 comparte con la comunidad académica los resultados y las experiencias significativas obtenidas a partir de los procesos de investigación creación, aprendizaje basado en retos (el ABR), el Modelo de Aprendizaje Aumentado Areandina y la estrategia del Proyecto Integrador de Semestre (PISE) que han permitido analizar diferentes contextos sociales, culturales y económicos de manera acertada, aportándoles a las diferentes líneas de investigación de la Facultad de Diseño Comunicación y Bellas Artes.
Se realiza una exploración de las diferentes temáticas y manifestaciones artísticas en el mundo: la cosmología de la cultura muisca en paralelo con el simbolismo del grupo subcoreano Bulletproof Boy Scouts (BTS); los circos y espectáculos que ya no utilizan animales, pero sí se reinventaron con la ayuda de la tecnología, pasando por las danzas y folclor de diferentes culturas, hasta aquellos cantos y música reconocidos por su evolución; los carnavales y fiestas, las tradiciones, rituales y herencias que son considerados patrimonio inmaterial de la humanidad. A su vez, los grupos de octavo semestre participaron en el concurso nacional Premio Mario Hernández en la categoría de producto, en los diferentes retos sugeridos, con una visión de sostenibilidad activa y de identidad cultural latinoamericana.
Decolonising through co-curation? Women creators of the future, Festival Films Femmes Afrique and Leeds International Film Festival
Authors: Johnson Rachel
Published: February 2025

Amidst calls from Decolonise and Black Lives Matter movements, several film festivals are engaged in the beginnings of a “reorientation,” a shift in their understandings of, and relationships to, colonial power structures. Considering decoloniality as a plural process rather than a singular endpoint, this article examines a recent example of such reorientation: Women Creators of the Future is a programme of films made by women of African heritage, co-curated by Festival Films Femmes Afrique (Senegal) and Leeds International Film Festival (UK). Taking its inspiration from a previous Films Femmes Afrique programme of the same name, this initiative constitutes a meeting of festival “worlds” that tells us much about burgeoning processes of decolonisation in cultural organisations. Combining fieldwork with interviews and self-reflexive analysis, I trace the complex relationships between curation, funding, placemaking and labour that underpinned the collaboration. I argue that this meeting of two contrasting festivals illuminates emerging practices of decolonising through co-curation, yet also invites us to reflect on the need for practices that more fully address both epistemic and economic injustice.
Effects of Nutritional Counselling on Dietary Intake and Nutritional Status of Pregnant Women Attending Health Facilities In Dang Province 5 Nepal
Authors: Pradhan Jaya Laxmi , Devkota Pooja , Sen Sita Kumari , Bhatta Nirmala
Published: February 2025

Background: Proper nutrition counselling on healthy food habit to all pregnant women can be a strong weapon to achieve good health of mothers as well as healthy offspring. The main objective of this research was to assess the effectiveness of nutritional counseling on dietary intake and nutritional status of pregnant women.Methods: Quasi-experimental research design was used to evaluate the effectiveness of nutritional counselling on dietary intake and nutritional status of pregnant women. The study area was chosen based on nonprobability purposive sampling technique and 110 participants who were pregnant before 20 weeks of gestation were included in the study who attended district hospital Lamahi and health post of Sisahaniya, Dang.Risults: Mid Upper Arm Circumference (MUAC) measurement of pregnant women showed that 11.8% pregnant women were malnourished (MUAC <22cm) before intervention. The proportion of MUAC measurement improved after nutritional counseling (4.5%). Almost all participants consumed rice, and roti as main foods. Frequency of consuming dal, green vegetables, fruits, milk and milk products, meat, fish, and egg increased after nutrition counseling. The result indicated that the consumption of carbohydrate, protein, fat and energy increased after nutrition counseling (Carbohydrate-226 vs 289g, protein- 65 vs 77g, fat- 43 vs 50g, energy- 1648 vs 2041kcal). Conclusions: Maternal nutrition during pregnancy is crucial for achieving healthy maternal and fetal outcomes. Nutrition counselling showed positive effects on nutritional status of pregnant women. Thus, nutrition counselling is essential for all pregnant women. It should be a major part of Antenatal care service to all pregnant women in Nepal.Keywords: Malnutrition; malnutrition; maternal and fetal outcome; nutrition counseling; underweight.
Sonography as an Adjunct to Digital Mammography in Patients with Dense Breasts
Authors: Jha Anamika , Regmi Pradeep Raj , Pradhan Huney , Thakur Minaxi , Joshi Birendra Raj
Published: February 2025

Background: Dense breasts are associated with an increased risk of cancer and also mask lesions on mammograms. In our study, we evaluated the role of sonography as an adjunct to digital mammography in patients with dense breasts.Methods: Sonography of 676 female patients with American College of Radiology category C or D mammographic density was done in this prospective cross-sectional analytical study in the Department of Radiology, Tribhuvan University Teaching Hospital. The final imaging diagnosis was classified as per the American College of Radiology Breast Imaging Reporting and Data System categories. Tissue diagnosis was obtained in patients with sonographic category 3 solid lesions larger than 3 cm, category 4 and 5 lesions. The data were tabulated and analyzed using Statistical Package for Social Service (SPSS) for Windows version 22.Results: Additional sonography confirmed all BIRADS 1 mammograms as normal or benign, 95.7 % (112) of inconclusive, and 82.8% (n=135) of BIRADS 3 ones as benign. It had higher sensitivity and negative predictive value (100%) than mammography with similar accuracy. Most patients (479, 70.9%) had diagnostic indications. There were 540 (79.9%) cases in ACR BIRADS category c. A final diagnosis of benign (316, 46.7%) was most common, followed by normal (293, 43.4%) and malignant (67, 9.9%). The majority of the malignant lesions were Invasive Ductal Carcinoma (59, 88%). Conclusions: Additional sonography confirmed mammography findings as normal, benign, or suspicious for malignancy, definitely described morphology and extent of mass, and also guided biopsy. It had higher sensitivity than mammography in dense breasts. Keywords: Breast density; mammography; ultrasonography mammary.
Rare presentation of Eccrine Porocarcinoma
Authors: Giri Piyush , Pokhrel Shrinkhala , Pandey Pratishtha , Khadka Karuna , Kunwar Sushma , Banstola Laxman , Gurung Narendra Vikram
Published: February 2025

Eccrine porocarcinoma is a tumor of the sweat gland that mostly develops from an existing benign eccrine poroma. It is a rare cutaneous malignancy with a high risk of metastasis and recurrence. Known to affect the elderly population in general with no gender discrepancy, it presents as an ulcerative mass commonly in the trunk or head/neck region. Definitive diagnosis is made by histopathological findings of peculiar pleomorphic cells with nuclear hyperchromasia and mitotic activity, surrounded by ductal lumen. The standard treatment is complete surgical excision with appropriate surgical margins; adequate work-ups to look for metastasis and timely follow ups for chances of recurrence. Here we report a case of an 82-year-old patient who presented at our department with a long-standing exophytic lesion in the head that rapidly started growing in the past few weeks. After excisional biopsy and histopathology, the diagnosis of Eccrine porocarcinoma was made.Keywords: Cutaneous; eccrine porocarcinoma; malignancy; rare.
Clinical Profile of Metabolic Derangements in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Authors: Aryal Saroj Babu , Panthi Akriti , Aryal Nadira , Risal Bijay
Published: February 2025

Background: Chronic obstructive pulmonary disease is defined as a preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation attributable to airway accompanied by alveolar abnormalities elicited by significant exposure to noxious particles or gases. Stress hormone is involved in proclivity towards causation of hyperglycemia and hyponatremia in COPD.Methods: This study is an analytical cross sectional single center study that was carried out in Tribhuvan University Teaching Hospital. Specimens were processed as per the guidelines of Standard Operating Procedure (SOP) of Biochemistry laboratory of Tribhuvan University Teaching Hospital.Results: In this study of 138 patients with acute exacerbation of COPD, the mean age was (71.88±9.771) years with higher prevalence in the age group between 70-80 years of age. Females (65.2%) outnumbered males and 71.7% came from outside the Kathmandu valley. Hyponatremia was observed in sodium levels with 51.4% below normal with majority of patient’s possessing mixed acid-base disorders (58.7%). Most of thepatients 76.5% received general care with a mean hospital stay of 8.7 days. Statistical analysis revealed significant associations between care type, geographical distribution (p=0.026) and duration of stay with care type (p=0.0001). No significant associations were found regarding gender, glucose, sodium, potassium levels and age with duration of stay. Conclusions: Factors such as age, gender, and glycemic status did not significantly affect the type of care or duration of hospital stay, geographical location emerged as a significant determinant, with patients from outside the Kathmandu valley more likely to receive general care. Despite the prevalence of electrolyte imbalances and acid-base disorders, these biochemical factors showed no substantial impact on clinical outcomes, suggesting that other factors may play a more significant role in duration of stay.Keywords: Acid-base imbalance; biochemistry; glucose; potassium; pulmonary.
Commentary on the review paper: Mapping the Health and Medical Research Excellence in Nepal: A Study of High-Cited Papers During 1994-2023
Authors: Subedi Narayan , Paudel Susan
Published: February 2025

N/A
Digitaalisten opetusmenetelmien yhteys oppilaan motivationaalisiin uskomuksiin yläkoulussa
Authors: Vilenius Elina , Vainikainen Mari-Pauliina
Published: February 2025

Tässä tutkimuksessa tarkastellaan digitaalisen teknologian opetuskäytön yhteyttä 7.–9.-luokkalaisten oppilaiden motivationaalisiin uskomuksiin toiminnan kontrolli teorian (action-control-theory) viitekehyksessä tutkien motivationaalisten uskomusten kehittymistä yhden lukuvuoden aikana. Tutkimusaineistona hyödynnettiin kansallisesti edustavan DigiVOO-hankkeen kyselyaineistoa oppilas- (N=8560) sekä opettajatasolta (N=895). Aineisto analysoitiin käyttämällä toistettujen mittausten varianssianalyysia sekä kaksitasoista hierarkkista lineaarista regressioanalyysia. Oppilaiden motivationaaliset uskomukset heikkenivät kaikilla luokka-asteilla syksyn 2021 ja kevään 2022 mittauspisteiden välillä. Tulokset osoittivat oppilaiden yksilöllisten tekijöiden olevan yhteydessä oppilaiden motivationaalisiin uskomuksiin. Sukupuolieroja havaittiin uskomusten lähtötason huomioimisen jälkeen ainoastaan kontrolliodotuksessa, johon liittyvät arviot olivat tytöillä matalammat poikiin nähden. Tulokset tukevat aikaisempia tutkimustuloksia sen osalta, että oppilaiden vanhempien koulutustausta oli yhteydessä oppilaiden motivationaalisiin uskomuksiin. Sen sijaan opettajien raportoiman digitaalisen teknologian opetuskäytön ja oppilaan uskomusten välillä ei ollut tilastollisesti merkitsevää yhteyttä tämän tutkimusotoksen perusteella. Opettajien pedagogisia valmiuksia tulisi vahvistaa, jotta digitaalisen teknologian opetuskäyttö tuottaisi aitoa lisäarvoa oppimiselle ja tukisi oppilaan digiosaamisen kehittymistä.
Efektivitas Model Pembelajaran STEM-Guided Inquiry Berbasis Kearifan Lokal "Dawet Ireng" Terhadap Literasi Sains Siswa Kelas VIII Pada Materi Unsur, Senyawa, dan Campuran
Authors: Elennita Elennita , Indriyanti Nurma Yunita , Nugraheni Febriani Sarwendah Asri
Published: February 2025

Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran STEM-Guided Inquiry berbasis kearifan lokal dawet ireng terhadap literasi sains siswa kelas VIII pada materi unsur, senyawa, dan campuran. Jenis penelitian yang digunakan yakni eksperimen semu dengan desain pretest-postest control group. Populasi penelitian ini adalah seluruh siswa kelas VIII SMPN 35 Purworejo, Kabupaten Purworejo tahun ajaran 2023/2024. Sampel penelitian ini adalah Kelas VIII C dan Kelas VIII D yang diperoleh dengan teknik cluster random sampling. Kelas VIII C (30 siswa) sebagai kelas kontrol dan Kelas VIII D (30 siswa) sebagai kelas eksperimen. Pengumpulan data dilakukan dengan teknik tes berupa soal essay literasi sains dan non tes berupa angket literasi sains. Keabsahan data diperoleh dari uji validitas dan uji reliabilitas. Analisis data prasyarat menerapkan uji normalitas kolmogorow-smirnov dan uji homogenitas levene. Hipotesis penelitian menggunakan uji hipotesis pihak kanan (one-tailed) melalui uji independent sample t-test yang dibantu dengan program SPSS 22. Hasil penelitian menunjukkan bahwa nilai thitung > ttabel yakni 15,613 > 1,672 dengan taraf signifikan 5%, sehingga H1 diterima. Hasil uji peningkatan n-gain juga menunjukkan bahwa skor n-gain kelas eksperimen sebesar 0,577 (kategori sedang) dan kelas kontrol -0,037 (kategori rendah). Berdasarkan hasil penelitian dan analisis data disimpulkan bahwa model pembelajaran STEM-Guided Inquiry berbasis kearifan lokal dawet ireng efektif dalam meningkatkan literasi sains siswa kelas VIII pada materi unsur, senyawa, dan campuran.
Towards a Green Health Technology Assessment: embedding Life Cycle Assessment for sustainable choices
Authors: Bobini Michela , Di Brino Eugenio , Cicchetti Americo
Published: February 2025

The healthcare sector significantly contributes to global greenhouse gas emissions. Among the various strategies available, exploring the integration of environmental sustainability into Health Technology Assessment (HTA) presents a potential avenue for addressing these impacts. The HTA Core Model, widely utilized by European HTA agencies, evaluates healthcare technologies across nine domains; however, environmental considerations remain peripheral and are primarily confined to certain safety-related aspects. This paper examines the potential role of Life Cycle Assessment (LCA) in complementing HTA to better address environmental impacts. LCA offers a systematic methodology to evaluate environmental effects across the full lifecycle of a product, from raw material extraction to disposal. Through the analysis of pharmaceuticals, telemedicine, and surgical practices, the study identifies critical environmental impacts at various lifecycle stages, illustrating how LCA could support more informed and sustainable decision-making in healthcare. These findings underscore the diverse environmental impacts associated with healthcare technologies and highlight the need for tailored strategies to mitigate them. This point of view emphasizes the importance of initiating discussions on developing a framework to incorporate environmental impacts into HTA systematically, promoting healthcare decisions that prioritize both human and environmental healths.
Kapasitas Masyarakat dan Pemerintah Desa dalam Menghadapi Bencana Longsor di Desa Harkatjaya Kabupaten Bogor
Authors: Lana Reni , Komala Dewi Indarti , Syahbandar M. Yogie
Published: February 2025

ABSTRAK
Desa Harkatjaya di Kecamatan Sukajaya, Kabupaten Bogor merupakan salah satu daerah rawan bencana tanah longsor. Pada tahun 2021, telah terjadi 5 kali bencana tanah longsor di desa tersebut. Untuk mengurangi risiko bencana tanah longsor, kapasitas masyarakat dan pemerintah daerah perlu ditingkatkan. Penelitian ini bertujuan untuk mengetahui kapasitas fisik, kapasitas ekonomi, kapasitas sosial, dan kapasitas pemerintah daerah dalam penanggulangan bencana tanah longsor di Desa Harkatjaya. Pengumpulan data dilakukan dengan observasi lapangan, penyebaran kuesioner, wawancara ahli, studi literatur, dan survei. Metode analisis yang digunakan adalah Sistem Informasi Geografis (SIG), metode analisis pembobotan (kuantitatif), dan metode analisis deskriptif. Hasil penelitian menunjukkan bahwa kapasitas masyarakat desa dan Pemerintah Desa Harkatjaya secara keseluruhan adalah sedang (65%) dan rendah (35%).
 
ABSTRACT
Harkatjaya Village in Sukajaya Sub-District, Bogor District is an area prone to landslides. In 2021, there have been 5 landslides in the village. To reduce the risk of landslides, the capacity of the community and local government needs to be increased. This research aims to identify the physical capacity, economic capacity, social capacity, and local government capacity in dealing with landslides in Harkatjaya Village. Data collection was carried out by field observation, distributing questionnaires, expert interviews, literature studies, and surveys. The analytical methods used are Geographic Information Systems (GIS), weighting analysis methods (quantitative), and descriptive analysis methods. The research result shows that the overall capacity of the village community and the Harkatjaya Village Government is medium (65%) and low (35%).
As Percepções das Crianças com TEA sobre sua Escola de Educação Especial
Authors: De Oliveira Carvalho Geovana Aparecida , Brandelero Camargo Gisele
Published: February 2025

Esse texto traz considerações de uma pesquisa cujo objetivo foi compreender as percepções das crianças com Transtorno do Espectro Autista (TEA), por meio das suas falas, verbais e não verbais, sobre seu processo escolar em uma escola de Educação Especial. Com abordagem qualitativa, essa pesquisa exploratória teve como objeto de estudo essas formas de comunicação das crianças com TEA acerca de sua inserção na escola. Pelo viés da Sociologia da Infância, compreende-se a criança como sujeito histórico, cultural e social, detentora de direitos, competente para interpretar e agir no mundo que vive. Com essa perspectiva, os dados da pesquisa foram coletados em uma escola de Educação Especial, com as crianças do Ensino Fundamental, por meio de observação e entrevistas individuais. Os resultados da pesquisa apontam que a criança com TEA, mesmo com suas especificidades e alterações no aspecto da comunicação, expressa-se eficientemente quando interage em um espaço propício e através de meios que permitam tal feito. Considerando suas percepções de mundo, suas falas são importantes e podem influenciar os contextos em que estão inseridas.
In vitro evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future in vivo applications
Authors: Lopes Bruna , Sousa Ana Catarina , Sousa Patrícia , de Sousa Moreira Alícia , Coelho André Filipe , Atayde Luís , Salgado António J. , Geuna Stefano , Alvites Rui , Maurício Ana Colette
Published: February 2025

Introduction

Peripheral nerve injuries, resulting from trauma or medical interventions, present significant clinical challenges due to their severe physiological and functional impacts. Despite various therapeutic approaches, optimal methods for promoting nerve regeneration remain difficult to obtain. This study is a preliminary step towards the future use of chitosan nerve guide conduits combined with human dental pulp stem cells and their conditioned media to promote nerve regrowth in a rat model with severe sciatic nerve damage.

Methods

Preliminary characterization of conditioned medium from human dental pulp stem cells identified key regenerative biomarkers using a Multiplexing LASER Bead analysis. The human dental pulp stem cells’ cytocompatibility with Reaxon® chitosan biomaterial was confirmed through viability and metabolic assays in a PrestoBlue assay, along with scanning electron microscopy and energy-dispersive X-ray spectroscopy analyses.

Results

These in vitro assessments validated the therapeutic potential of the combinations for nerve regeneration.

Discussion

Future in vivo experiments will involve applying these combinations in a rat model, with functional assessments to evaluate efficacy. This research aims to establish human dental pulp stem cells and nerve guide conduits as viable treatments for peripheral nerve injury, offering promising directions for clinical applications.
Baseline HBsAg quantitative and CD4 T cell counts are associated with HBsAg loss in people living with HIV/HBV coinfection after combined antiretroviral therapy
Authors: Xia Muye , Zhao Yuhang , Yu Tao , Lin Xiaoli , Liao GuiChan , Jiang Yuanhui , Mao Jingchun , Peng Jie , Cai Shaohang
Published: February 2025

Background

Achieving Hepatitis B surface antigen (HBsAg) loss is a significant goal for chronic hepatitis B patients. This study aims to evaluate HBsAg loss in individuals with HIV/HBV coinfection and explore the association of clinical variables with this outcome.

Methods

We enrolled 138 individuals coinfected with HIV/HBV and 480 HBV mono-infected individuals who initiated antiviral treatment. We employed Kaplan-Meier analysis to compare the rate of HBsAg loss between individuals with HIV/HBV coinfection and those with HBV mono-infection. In the HIV/HBV coinfected cohort, we used Cox proportional hazards models to assess the association between various factors and the incidence of HBsAg loss.

Results

The cumulative HBsAg loss rate was higher among HBV/HIV coinfected individuals (13 patients, 11.5% at year 3) compared to HBV mono-infected individuals (1 patient, 0.6%) after antiviral therapy. In the HIV/HBV coinfected cohort, the multivariable analysis revealed that lower baseline HBsAg level (HR 0.53; 95% CI 0.38-0.74, p<0.001) and baseline CD4 T cell counts < 180 cells/uL (HR 0.32; 95% CI 0.10-0.96, p=0.042) were associated with an increased indicator of HBsAg loss. Additionally, the receiver-operating characteristic curve analysis indicated an area under the curve of 0.771 for baseline HBsAg levels and 0.758 for baseline CD4 cell counts at year 1 in predicting HBsAg loss.

Conclusions

After antiretroviral therapy, HIV/HBV coinfected adults achieve higher rates of HBsAg loss. Baseline HBsAg quantitative and CD4 T cell counts are associated with HBsAg loss in individuals with HIV/HBV coinfection after combined antiretroviral therapy and may inform treatment decisions.
Plasma cell-free DNA Droplet Digital PCR provides rapid and efficient infectious microbiology diagnosis for febrile haematological patients
Authors: Li Ying , Xiao Jun , Xia Lihui , Sun Xueqin , Li Jia , Bai Huili
Published: February 2025

Background

Febrile haematological patients are at high risk for potential bloodstream infections, the rapid and accurate identification of pathogens is crucial for clinical diagnosis and treatment. Droplet Digital PCR (ddPCR) is a novel and ultra-sensitively molecular technique for the rapid detection of pathogens. We evaluated the ability of ddPCR to identify infectious etiologies to discuss the applicability of ddPCR in the diagnosis and treatment of infections for febrile haematological patients.

Methods

This study enrolled and analyzed 89 ddPCR tests performed on 71 febrile haematological patients. We conducted a comparison between ddPCR results, blood culture (BC), and conventional microbiological testing (CMT). Additionally, we analyzed the correlation between ddPCR results and inflammatory factors, as well as their impact on antimicrobial therapy.

Results

DdPCR detected 113 pathogens in 72 plasma samples, while CMT identified 39 pathogens in 32 plasma samples. The detection rate of bacteria and viruses using ddPCR was significantly higher than that of CMT (p <0.0001). The turnaround time (TAT) for pathogenic diagnosis was significantly shorter with ddPCR compared to CMT (p <0.0001). When we used the CMT as reference standard, the sensitivity and specificity of ddPCR were 93.8%, 26.3%, respectively. We observed a positive correlation between the ddPCR results and CRP, PCT and IL-6, and ddPCR (AUC=0.771) has better diagnostic performance. The anti-infective treatment strategies were adjusted for 30 patients based on the positive ddPCR results, with 86.7% (26/30) of these cases demonstrating effectiveness in the anti-infective treatment.

Conclusion

DdPCR has the potential to enhance pathogen detection in febrile haematological patients by offering high sensitivity, rapid, precise results, it demonstrates better diagnostic performance compared to inflammatory factors and can contribute to the real-time clinical optimization of antimicrobial regimens, thereby enhancing the efficacy of anti-infective therapy.
Next-generation approach to skin disorder prediction employing hybrid deep transfer learning
Authors: Gulzar Yonis , Agarwal Shivani , Soomro Saira , Kandpal Meenakshi , Turaev Sherzod , Onn Choo W. , Saini Shilpa , Bounsiar Abdenour
Published: February 2025

Introduction

Skin diseases significantly impact individuals' health and mental wellbeing. However, their classification remains challenging due to complex lesion characteristics, overlapping symptoms, and limited annotated datasets. Traditional convolutional neural networks (CNNs) often struggle with generalization, leading to suboptimal classification performance. To address these challenges, this study proposes a Hybrid Deep Transfer Learning Method (HDTLM) that integrates DenseNet121 and EfficientNetB0 for improved skin disease prediction.

Methods

The proposed hybrid model leverages DenseNet121's dense connectivity for capturing intricate patterns and EfficientNetB0's computational efficiency and scalability. A dataset comprising 19 skin conditions with 19,171 images was used for training and validation. The model was evaluated using multiple performance metrics, including accuracy, precision, recall, and F1-score. Additionally, a comparative analysis was conducted against state-of-the-art models such as DenseNet121, EfficientNetB0, VGG19, MobileNetV2, and AlexNet.

Results

The proposed HDTLM achieved a training accuracy of 98.18% and a validation accuracy of 97.57%. It consistently outperformed baseline models, achieving a precision of 0.95, recall of 0.96, F1-score of 0.95, and an overall accuracy of 98.18%. The results demonstrate the hybrid model's superior ability to generalize across diverse skin disease categories.

Discussion

The findings underscore the effectiveness of the HDTLM in enhancing skin disease classification, particularly in scenarios with significant domain shifts and limited labeled data. By integrating complementary strengths of DenseNet121 and EfficientNetB0, the proposed model provides a robust and scalable solution for automated dermatological diagnostics.
Mapping red algal blooms and their albedo-reducing effect on seasonal snowfields at Hardangervidda, Southern Norway
Authors: Chevrollier Lou-Anne , Wehrlé Adrien , Cook Joseph M. , Guillet Grégoire , Benning Liane G. , Anesio Alexandre M. , Tranter Martyn
Published: February 2025

Red snow algae bloom at the surface of snowfields worldwide, and their detection is relevant for ecological, biogeochemical and mass balance studies. In this study, we co-located RGB imagery acquired with a light-weight Uncrewed Aerial Vehicle (UAV) to 129 hyperspectral reflectance spectra from which the snow surface properties were retrieved, thereby enabling high-resolution aerial mapping of algal properties. We present maps of red snow algae abundance and albedo reducing effect over ∼ 9700 m2 of seasonal snowfields across Hardangervidda, Southern Norway, in July and August 2023. The average albedo reducing effect of the algae over the entire area was 0.012 ± 0.005, and attained 0.028 ± 0.004 on a snowfield of ∼ 710 m2. Across snow surfaces with visible blooms only, the algal albedo reducing effect was 0.045 ± 0.003, equivalent to an additional ∼ 3 mm of daily melting under local illumination conditions, and aggregating to 5,500 ± 2,300 kg of daily snowmelt. The intensity and spatial coverage of surface algal blooms were very variable between and within the individual snowfields. Analysis of the UAV imagery suggests that multiple small and distributed samples are at least twice more likely to yield representative estimates of the average snow algal concentration of a snowfield compared to fewer, larger samples. Our study demonstrates the potential of low-cost and easy to deploy UAVs for red snow algal monitoring at the cm to sub-cm scale, which can be used to better understand their spatial ecology and role in albedo reduction.
Internal exclusion as a “dumping ground”: analysis of the perspectives of parents whose children have experienced internal exclusion in UK schools
Authors: Trippler Kiana , Anderson Joanna , Burn Anne-Marie
Published: February 2025

Internal exclusion (IE) in the UK, wherein pupils are removed from their classroom and placed in a separate area within the school, has been implemented to mixed reception with the intention of reducing classroom disruptions. For this study, an online survey was completed by 34 parents of children who have experienced IE, focusing on parent perspectives of their children’s experiences and mental health (MH), with 67% of parents reporting that their child felt distressed or unhappy while in IE. Eleven parents also participated in a semi-structured interview. Thematic analysis of interviews generated three themes: (1) IE as a tool to manage disruption, (2) counterproductive implementation, and (3) breakdown of trust with the school. Results highlight that parents felt the implementation of IE was given inappropriately, negatively impacted their child’s MH, or was ineffective in improving behaviour. Parents of pupils with learning difficulties also found IE to be difficult, and suggested alterations to existing IE implementation to support communication between schools and families and to prioritise the voices of pupils and parents in the school environment at the whole-school level.
Preliminary quantitative analysis of renal sinus fat dysfunction in T2DM patients using MRI fat fraction and R2* mapping
Authors: Dong Yifan , Zhang Qinhe , Wang Xun , Liu Yuhui , An Qi , Zhang Ziting , Hu Lifang , Lin Liangjie , Liu Ailian
Published: February 2025

Purpose

To quantitatively analyze renal sinus fat (RSF) dysfunction in type 2 diabetes mellitus (T2DM) patients using magnetic resonance imaging (MRI) fat fraction (FF) and R2* mapping.

Methods

The inpatients who underwent 1.5 T MRI examination (including MRI FF and R2* mapping) of the abdomen from January 2017 to December 2023 were enrolled. The RSF volume, FF and R2* of the right and left kidneys and the mean values were measured. Associations between mean FF and R2* value of RSF and T2DM were assessed with logistic regression. Receiver operating characteristic (ROC) curve was applied to calculate area under the curve (AUC) for the parameters to identify T2DM patients. Partial correlation coefficients after controlling for age, sex, and BMI were computed to analyze the correlations among the mean RSF volume, FF and R2*.

Results

A total of 186 participants were finally enrolled in this study including 38 patients in T2DM group and 148 patients in non-T2DM group. Univariate logistic regression analyses showed the significant correlations of mean RSF FF (OR: 1.111, 95%CI: 1.054 - 1.171), P < 0.001) and R2* (OR: 1.120, 95%CI: 1.013 - 1.237), P = 0.027) with T2DM. Multivariate analysis showed that mean RSF FF (OR: 1.231, 95% CI: 1.098 - 1.380) is independently associated with T2DM after adjusting for age, sex and BMI. The AUC of mean RSF FF was 0.701 (0.630 - 0.766) with the sensitivity and specificity of 57.89% and 75.68%, respectively, when using 34.40% as the cut-off value. The AUC of mean RSF R2* was 0.616 (0.542 - 0.686) with the sensitivity and specificity of 68.42% and 58.11%, respectively, when using 21.97 Hz as the cut-off value. Furthermore, mean RSF FF presents significantly higher diagnostic efficacy for T2DM than R2* (P < 0.05). And combining mean RSF FF and R2* improved the diagnostic performance (AUC = 0.729).

Conclusion

Mean RSF FF and R2* were significantly associated with T2DM, and mean RSF FF was the independent risk factor of T2DM. This finding indicates the hypertrophy of adipocytes and excessive iron deposition and hypoxia in RSF, which may represent dysfunction of RSF for T2DM.
Functional annotation of eukaryotic genes from sedimentary ancient DNA
Authors: Çabuk Uğur , Herzschuh Ulrike , Harms Lars , von Hippel Barbara , Stoof-Leichsenring Kathleen R.
Published: February 2025

Sedimentary ancient DNA (sedaDNA) provides valuable insights into past ecosystems, yet its functional diversity has remained unexplored due to potential limitations in gene annotation for short-read data. Eukaryotes, especially, are typically underrepresented and have low coverage in complex metagenomic datasets from sediments. In this study, we evaluate the potential of eukaryotic gene annotation in sedimentary ancient DNA (sedaDNA) time-series data covering the last 23,000 years. We compared four gene annotation pipelines (GAPs) that apply Prodigal (ProkGAP) and MetaEuk (EukGAP) with and without taxonomic pre-classification. We identify ProkGAP as the pipeline which recovers the largest gene catalog with 6,568,483 functional genes and the highest number of eukaryotic functional genes (5,895 unique KEGG orthologs). Our findings show that ProkGAP, originally invented for prokaryotic gene prediction, yields the largest share of functional genes among all GAPs tested. At the same time, it allows the analysis of prokaryotic and eukaryotic gene functions in parallel and predicts most gene diversity. Interestingly, in our time-series data the gene catalog size and diversity show an increasing trend towards recent times indicating a more complex eukaryotic functional community during the Holocene. However, all gene annotation pipelines are limited by incomplete functional reference databases, which hamper the link between taxonomic-functional relationships when considering lower taxonomic levels. Future research on functional gene prediction from short read sedaDNA data should focus on expanding the eukaryotic databases and increasing sequencing depth to explore eukaryotic and prokaryotic functional composition and diversity in past ecosystems and their relationships to environmental change.
Epigenetic regulation of transcription factors involved in NLRP3 inflammasome and NF-kB signaling pathways
Authors: Kaszycki John , Kim Minji
Published: February 2025

The NLRP3 inflammasome and NF-κB signaling pathways play crucial roles in orchestrating inflammation and immune defense.​ This review explores the intricate relationship between these pathways and epigenetic regulation, a field of growing importance in understanding immune responses. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), significantly influence the activity of genes involved in these pathways, thereby modulating inflammatory responses. The review provides a comprehensive overview of current research on how epigenetic mechanisms interact with and regulate the NLRP3 inflammasome and NF-κB signaling pathways. It delves into advanced epigenetic concepts such as RNA modifications and 3D genome organization, and their impact on immune regulation. Furthermore, the implications of these findings for developing novel therapeutic strategies targeting epigenetic regulators in inflammatory diseases are discussed. By synthesizing recent advancements in this rapidly evolving field, this review underscores the critical role of epigenetic regulation in immune signaling and highlights the potential for epigenetic-based therapies in treating a wide range of inflammatory conditions, including autoimmune disorders and cancer.