bluuebunny/crossref_metadata_2025 huggingface dataset:
Regularities of weeding in crop rotation fields against the background of different tillage systems
Authors: Kryvenko A.I. , Pochkolina S.V. , Solomonov R.V.
Published: February 2023

It was found that during the research in winter wheat crops, 40 species of weeds of different biological groups and classes were registered. The most common weeds in the research are: spring (Polygonum aviculare, Fumaria officinalis); winter (Descurainiasophia, Capsella bursa-patoris, Veronica hederifolia, Thlaspiarvense), perennial (Cirsium arvense, Convolvulus arvensis). All of these weeds are non-parasitic weeds. They have roots, stems and green leaves, resulting in an independent diet.

It is shown that on average for 5 years of research the least number of weeds was recorded after black fallow (53,7 pcs / m²). Weeds were 22,0 % higher after winter weeds, 55,9 % more after a mixture of peas and mustard, and 95,3 % higher after peas for grain.

In the experiments, almost identical results on weediness of winter wheat crops were obtained with two tillage schemes, namely tillage and chisel tillage. However, there is a slight tendency to reduce the number of weeds (0,8 %) during chisel tillage.

There was an increase in the number of weeds on the 2nd (83,5 pcs / m2) and on the 4th (76,6 pcs / m2) crops compared to the 1st (64,3 pcs / m2). The highest tweediness (83,5 units / m2) of winter wheat crops was observed in the 2nd crop. This indicates a large potential contamination of the arable soil layer.

Key words: crop rotation, tillage, black fallow, green fallow, weeds, winter wheat, oats.
Effect of optimized fertilizer on leaf surface and yield of pear trees in repeated cultivation
Authors: Yakovenko R.V.
Published: February 2023

The results of studies on the effect of optimized fertilization ofpear plantations of the varieties Conferentsia and Osnovianska on morphological changes of the leaf apparatus and the yield of trees grown on dark gray podzolic heavy loamy soil in the Right-Bank Forest-steppe of Ukraine are considered. Under the optimization of mineral nutrition of these pear varieties in the unirrigated plantation, in different age periods of growth and fruiting, a significant increase in the total leaf area, each leafplate and its thickness was observed on the plots of optimized background with the additional introduction of N30 and N30K30.

The highest yields of both research pear varieties in the period of fruiting and growth were also provided by additional nitrogen and nitrogen-potassium nutrition with appropriate fertilization on the optimized background. In these cases, there was a significant increase in tree yield compared to the unfertilized, and fertilized with annual application of N90P60K90, where there was a less balanced ratio of N:P:K in plant nutrition, although the total amount of fertilizer was greater.

Key words: pear, fertilizer, variety, leaves, harvest, growth periods
Score Tomográfico de Severidad (TSS) como predictor de admisión a Unidad de Cuidados Intensivos (UCI) en pacientes con neumonía COVID-19 en una clínica de San Juan de Lurigancho Lima, Perú
Authors: Ravelo-Hernández Jorge L. , Aguirre-Quispe Wilfor , Quispe-Ayuque Edwin , Reyes-Rocha Gabriela , Hernández-Azuaje Josefina J.
Published: February 2023

Objetivo: Determinar si el Score Tomográfico de Severidad (TSS) de pacientes con neumonía COVID-19 a su ingreso, así como algunas pruebas de laboratorio o rasgos clínicos predicen el ingreso a UCI en este grupo de pacientes. Material y métodos: Estudio de casos y controles, que incluyó pacientes con diagnóstico clínico de Infección por virus SARS-CoV2, realizado mediante reacción en cadena de la polimerasa con transcriptasa inversa (RT-PCR), prueba serológica reactiva (IgM/IgG) y/o Tomografía Computarizada de tórax (TCT) sin contraste. Dos radiólogos (evaluadores ciegos) describieron los hallazgos tomográficos. Los datos fueron tomados de historias clínicas electrónicas (HCE). Se analizó las variables más importantes de predicción de ingreso a UCI: TSS, edad, IMC, obesidad, ferritina, Dímero D, saturación de O2, PO2, linfopenia, proteína C reactiva, y presencia de comorbilidades: Diabetes mellitus, HTA. La predicción de ingreso a UCI se realizó mediante regresión logística binaria para un OR ajustado, que comparaba 2 modelos de análisis con un IC 95 % y un p valor <0,05; como estadísticamente significativo. Resultados: Se incluyeron 168 participantes. La comorbilidad más frecuente fue la hipertensión arterial, seguido por diabetes tipo 2; los síntomas más frecuentes en nuestra serie fueron tos, malestar general, fiebre y dificultad respiratoria, no hubo diferencias significativas entre los grupos estudiados (Ingresados a UCI y No ingresados a UCI). La edad media de los pacientes No ingresados a UCI fue 44.89 ± 10.9 años y de los ingresados a UCI 43.81 ± 11 años (p: 0.669). La media del valor de Score TSS fue 14(SD 4.44) en ingresados UCI vs. 7.77(SD 4.81) en no ingresados a UCI (p<0.001), La media del Dímero D fue 0.78 (SD 2.74) en no ingresados a UCI vs. 4.72(SD 9.72) en ingresados a UCI (p<0.001). Además, la predicción para el ingreso a UCI por regresión logística binaria mostró en el modelo 2, que las siguientes variables: TSS(OR: 1.24) (IC 95 % 1.08-1.43) (p₌ 0.002), IMC (OR: 1.19) (IC 95 % 1.02-1.39)(p₌ 0.022) ,Edad (OR: 0.94)(IC 95 % 0.89-0.99) (p₌ 0.047) y Dímero D (OR: 1.14) (IC 95 % 1.04-1.26)(p₌ 0.05), fueron las variables con mejor valor predictor. Conclusiones: El Score TSS fue útil en la evaluación diagnóstica inicial de neumonía COVID-19, en conjunto a marcadores como Dímero D, IMC y edad que pueden predecir un mal resultado a corto plazo. Un Score TSS ≥ 8 en pacientes con neumonía COVID 19 en su admisión hospitalaria puede ser considerado predictor de admisión a UCI, en los pacientes estudiados.
Peningkatan Kemampuan Basic Life Support Orang Awam Melalui Training Program Metode Group Competition
Authors: Muliyadi Muliyadi , Panesia Lisa , Sari Ayu Puspita , Rara Rara
Published: February 2023

Latar Belakang: Gangguan Airway (Jalan Nafas), Breathing (bernafas dengan Spontan) dan Circulation (Sirkulasi darah) merupakan suatu kondisi kedarutatan yang dapat menyebabkan kematian jika tidak dilakukan pertolongan dengan segera. Penelitian ini bertujuan untuk memperoleh gambaran peningkatan kemampuan orang awam khusus (satpam) dalam memberikan bantuan hidup dasar setelah dilakukan training Basic Life Support. Methods: Merupakan penelitian pre-eksperiment dengan pre dan post test design. Sampel sepuluh orang satpam Poltekkes Kemenkes Palembang, yang ditentukan secara purposive sampling. Pengumpulan data dilakukan melalui kuesioner dan lebar check list observasi. Analisis dilakukan secara univariat dan bivariate melalui uji T Dependent.  Hasil: Analisis penelitian diperoleh terjadi peningkatan pengetahuan dan keterampilan tentang BLS secara signifikan setelah dilakukan pelatihan BLS dengan metode kompetisi group, pvalue 0,0001. Kesimpulan: Training program dengan metode group competition meningkatan kemampuan Basic life support.
Hubungan Merokok dengan Kejadian Hipertensi di Puskesmas Kampus Palembang
Authors: Erman Imelda , Damanik Hanna DL. , Sya'diyah Sya'diyah
Published: February 2023

Latar belakang : Salah satu penyebab kematian tertinggi pada masyarakat didunia saat ini adalah hipertensi. Gaya hidup adalah penyebab peningkatan terjadinya hipertensi yaitu kebiasaan  merokok. Tujuan penelitian ini untuk mengetahui  hubungan antara kebiasaan merokok, lama merokok, jumlah rokok perhari, dan jenis rokok dengan kejadian hipertensi. Metode : Alat pengumpulan data menggunakan kuesioner kebiasaan merokok. Teknik pengumpulan sampel pada penelitian ini dengan teknik nonprobability sampling jenisnya purposive sampling yang berjumlah 47 responden. Analisis statistik menggunakan uji Chi-Square dengan tingkat kemaknaan (p<0,05). Hasil : Didapatkan adanya hubungan antara kebiasaan merokok (p-value=0,005) dan jenis rokok (p-value=0,050) dengan kejadian hipertensi sedangkan untuk hasil lama merokok serta jumlah rokok didapatkan tidak adanya hubungan dengan kejadian hipertensi. Kesimpulan : Ada hubungan kebiasaan merokok dan jenis rokok dengan kejadian hipertensi di Puskesmas Kampus Palembang.
Pengaruh Senam Ergonomis Terhadap Kadar Asam Urat Pada Lansia di Wilayah Kerja Puskesmas Merdeka Kota Palembang
Authors: Erman Imelda , Ridwan Ridwan , Putri Rahayu Dwi
Published: February 2023

Latar Belakang : Lanjut Usia akan menimbulkan masalah kesehatan karena terjadi Penurunan fungsi tubuh. Salah satu masalah lansia adalah penurunan fungsi muskuloskeletal yaitu Arthritis Gout. Olah raga senam ergonomis merupakan aktivitas fisik yang diketahui dapat membantu menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui pengaruh senam ergonomis terhadap kadar asam urat pada lansia di Wilayah Kerja Puskesmas Merdeka Kota Palembang. Metode : Penelitian Quasi Eksperimental dengan rancangan penelitian Non Equivalent Control Group Design. Teknik pengumpulan sampel dalam penelitian ini adalah non probability sampling dengan pendekatan purposive sampling dengan jumlah sampel 30 responden, 15 kelompok perlakuan dan 15 kelompok kontrol.  Pengumpulan data menggunakan pemeriksaan kadar asam urat darah. Analisa pengaruh senam terhadap kadar asa urat  menggunakan uji statistik Mann Whitney U. Hasil : Hasil penelitian menunjukkan  terdapat perbedaan signifikan rata-rata kadar asam urat sebelum dan sesudah dilakukan Senam Ergonomis p Value = 0,001. Kesimpulan : Senam ergnomis merupakan salah satu aktivitas fisik yang dapat menurunkan kadar asam urat pada lansia.
Analisis Hubungan Beban Kerja dengan Stres Kerja Perawat: Literature Review
Authors: Mariana Evi Risa , Ramie Agustine
Published: February 2023

Latar belakang : Perawat merupakan profesional kesehatan yang berisiko mengalami stress. Persentase kejadian stress didunia sekitar 74% dialami perawat. Stres yang terjadi pada perawat dipengaruhi oleh beban kerja yang berlebihan. Penelitian ini bertujuan untuk mengetahui hubungan beban kerja dengan stres kerja perawat. Metode: Desain yang digunakan adalah literature review, artikel dikumpulkan dengan menggunakan mesin pencari yaitu Researchgate,  Google Scholar, Portal Garuda, medline dan Pubmed. Kriteria artikel yang digunakan adalah yang diterbitkan tahun 2018-2020. Berdasarkan hasil literature review didapatkan semua artikel menunjukkan ada hubungan antara beban kerja dengan stres kerja perawat. Hasil: analisis statistik tujuh artikel dari sembilan artikel didapatkan nilai p < 0,05, artinya terdapat hubungan antara beban kerja dengan stres kerja perawat dan dua artikel menunjukkan hubungan beban kerja dengan stres kerja memiliki hubungan kategori kuat dan positif Kesimpulan : Semakin tinggi beban kerja yang dialami perawat maka akan semakin tinggi tingkatan stres.
Perkembangan Rumah Sakit di Indonesia di Era Disruptif
Authors: Hammad Hammad , Ramie Agustine
Published: February 2023

Latar Belakang: Rumah sakit sejatinya bagian dari kebutuhan primer masyarakat yang selama ini menjadi prioritas utama oleh masyarakat. Perkembangan dunia yang sangat cepat menuntut rumah sakit harus beradaptasi dengan dengan perkembangan industry 4.0 saat ini. Metode: Penelitian ini ditulis dengan menggunakan analisis data sekunder yang didapat dari  Kementerian Kesehatan. Hasil: Jumlah rumah sakit di Indonesia, ditinjau dari kepemilikan baik milik pemerintah maupun swasta dari tahun 2015-2019 terus mengalami berbagai peningkatan termasuk dalam hal perbandingan tempat tidur terhadap jumlah penduduk di Indonesia. Kesimpulan: Perkembangan fasilitas atau sarana prasarana rumah sakit sangat penting di era modern sekarang ini. Peningkatan kualitas dan kuantitas rumah sakit tentu harus dibarengi dengan peningkatan tenaga kesehatan yang secara langsung berinteraksi dengan pasien maupun tenaga non kesehatan lainnya sehingga terjadi peningkatan kualitas layanan kesehatan yang diberikan.
Teknik Relaksasi Nafas Dalam dan Aromaterapi Lavender Untuk Menurunkan Nyeri Post Sectio Caesarea
Authors: Ningsih Ratna , Adelia Adelia
Published: February 2023

Latar Belakang : Masalah pada persalinan sectio caesarea memiliki nyeri lebih tinggi sekitar 27,3% dibandingkan persalinan normal hanya 9%. Nyeri pengalaman sensorik dan emosional yang tidak menyenangkan akibat kerusakan jaringan yang persepsi nyerinya bersifat sangat subyektif. Tujuan: Membandingkan masalah nyeri pada kedua pasien Post Sectio Caesarea dengan teknik relaksasi nafas dalam dan aromaterapi lavender. Metode: Jenis penelitian deskriptif analitik dengan pendekatan studi kasus untuk mengeksplorasi asuhan keperawatan pasien post sectio caserea dengan teknik relaksasi nafas dalam dan aromaterapi lavender. Subjek studi kasus dua pasien dengan inisial Ny.E berusia 26 tahun, dan Ny.K berusia 25 tahun. Asuhan keperawatan dilakukan pada salah satu rumah sakit swasta Palembang, serta proses pengambilan asuhan keperawatan tanggal 05−07 April 2021. Hasil: Pengkajian didapatkan pada Ny. E skala nyeri 6, sedangkan Ny. K skala nyeri 7, kedua pasien menyatakan nyeri bertambah parah ketika bergerak. Intervensi berfokus utama diagnosis nyeri memiliki tujuan nyeri menurun. Pemberian implementasi tidak terdapat perbedaan pada kedua pasien, hasil evaluasi pada Ny. E dan Ny. K dapat menurunkan skala nyeri. Saran: diharapkan menerapkan teknik relaksasi nafas dalam disertai aromaterapi lavender pada pasien post sectio caesarea serta dikembangkan lagi dan menjadi pembelajaran untuk penelitian selanjutnya.
Faktor-faktor yang Berhubungan dengan Bounding Attachment Pada Masa Nifas
Authors: Italia Italia , Sari Erni Novita
Published: February 2023

Latar Belakang. Menurut WHO (World Health Organization), di seluruh dunia setiap menit seorang perempuan meninggal karena komplikasi yang terkait dengan kehamilan, persalinan dan nifas. Bounding adalah ikatan antara ibu dan bayi dalam masa awal neonatus, sedangkan attachment adalah sentuhan. Faktor-faktor yang berhubungan dengan bounding attachment adalah pengetahuan, pendidikan, umur, paritas, peran petugas kesehatan dan dukungan suami. Tujuan penelitian untuk mengetahui faktor-faktor yang berhubungan dengan bounding attachment pada masa nifas. Metode penelitian menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah semua ibu nifas yang sedang menjalani perawatan di praktik bidan mandiri Misni Herawati Palembang dengan jumlah sampel sebanyak 25 responden dengan menggunakan metode accidental sampling. Analisis menggunakan analisis univariat (distribusi tiap variabel) dan analisis bivariat untuk mengetahui hubungan antara variabel independen dan varibel dependen. Hasil penelitian didapatkan distribusi frekuensi responden yang melakukan bounding attachment pada kategori baik sebanyak 16 responden (64%), peran petugas kesehatan pada kategori baik sebanyak 13 responden (52%), paritas tinggi sebanyak 14 responden (56%), responden yang mendapat dukungan suami sebanyak 17 responden (68%). Hasil uji statistik didapatkan ada hubungan yang bermakna antara peran  petugas kesehatan (pvalue = 0,004), paritas (p value = 0,017) dan dukungan suami (pvalue = 0,010) dengan bounding attachment pada ibu nifas. Kesimpulan: Bounding attachment berhubugan dengan paritas ibu dan  dapat ditingkatkan melalui peran petugas kesehatan dan dukungan suami.
Pengaruh Model Supporting, Action, Well-Being, Education & Training, Holistic (Sabeth) Dalam Meningkatkan Self Awareness Untuk Mencegah HIV: Analisis Statement
Authors: Sinulingga Elysabeth
Published: February 2023

Latar belakang: Self awarenes atau kesadaran diri merupakan salah satu konsep yang dapat dikembangkan dalam upaya pencegahan HIV. Salah satu kegiatan yang bisa menimbulkan kesadaran diri yaitu sadar diri kita ini manusia yang memiliki hubungan dengan Tuhan. Kesadaran diri untuk mencegah perilaku HIV adalah direncanakan melalui Program Supporting, Action, Well-Being, Education and Training (SABETH). Metode: dari konsep yang digunakan dalam penelitian dirumuskan  statemen dengan langkah: menseleksi statement untuk dianalisis: penyederhanaan statemen;  mengklasifikasi statement; menguji konsep dalam statement untuk definisi dan validasi; menentukan hubungan antar konsep berdasarkan tipe, tanda dan kesimitrian, menguji kelogisan dan memutuskan testabilitas. Hasil: Program SABETH adalah suatu paket intervensi keperawatan holistik yang berorientasi pada membantu pasien, keluarga atau masyarakat dalam mengidentifikasi dalam kebutuhan dan kemampuan dalam meningkatkan pengetahuan, skill, sikap dan kemudian melaksanakan pengelolaan dirinya. Suporrting: Informasi tentang pencegahan HIV dan perawatan diri; Action: Memelihara kemampuan pasien dalam merawat diri dan mencegah penularan HIV. Well-being: Mampu meningkatkan efikasi diri dengan mengidentifikasi hambatan; Education: meningkatkan pengetahuan tentang pencegahan HIV; Training: Pelatihan yang ditujukan untuk meningkatkan self awareness bagi pasien, keluarga, masyarakat agar pasien HIV hidup berkualitas; Holistic: mandiri dalam perawatan diri fisik, psikologi, sosial, budaya dan spiritual dengan dukungan keluarga dan masyarakat.
AN UNUSUAL ASSOCIATION OF PARTIAL UNILATERAL LENTIGINOSIS AND CENTRAL HETEROCHROMIA
Authors: Goyal Megha , Verma Anurag , Singh Tomar Suyash , Alam Afroz
Published: February 2023

Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder that is characterized by multiple clustered lentigens on a
normal skin in a segmental pattern with a sharp demarcation at the midline. Heterochromia is a condition of the eye in
which there is variation in iris colour of one or both eyes. There has been multiple associations of PUL and has also been associated with ocular
involvement but has never been associated with heterochromia. Herein we report an undocumented association of PUL with central
heterochromia.
HISTOPATHOLOGY OF GALLBLADDER SPECIMENS AFTER CHOLECYSTECTOMY: A RETROSPECTIVE STUDY
Authors: Fatima Ayesha , Uplaonkar Shilpa
Published: February 2023

Background Current approach to detect the presence of gallbladder carcinoma involves a routine histopathological
examination of all gallbladder specimens, regardless of the clinical characteristics of the patient or macroscopic aspect of
the gallbladder. Available pathological reports were interpreted for the following parameters: age, gender, and pathological diagnosis. In
addition, the demographic information and clinicopathologic characteristics of the patients with histopathologic ndings were assessed in detail,
and re-examination of the available specimens was done. Inpatient records of the Methods patients who had been operated for elective and
emergency cholecystectomies in the hospital associated with Khaja Bandanawaz University – Faculty of medical Sciences; from January 2018 to
November 2022, were retrospectively evaluated. Results A total of 661 gallbladder specimens submitted for histopathological examination
during the study period were included in the study. The results of histopathological examination of these gallbladder specimens showed that
chronic cholecystitis was found in 535 (81%), acute cholecystitis in 46 (6.99%), cholesterolosis in 44 (6.5%) patients, Dysplasia was found in 34
(5.14%) patients, and gallbladder carcinoma was detected in 2 (0.30%) patients. Conclusion A strategy of selective approach for
histopathological examination of gallbladder specimens may be safe in areas with very low incidence of gallbladder carcinoma. Such selective
strategy is more cost-effective, reduces the workload of pathologists, and does not appear to compromise patient outcome.
A Dynamic Time-Bound Access Control for Secure Hierarchical Content Sharing
Authors: Odelu Vanga
Published: February 2023

With rapid growth of mobile users, protecting content from unauthorized users become a complex problem. The concept of temporal role-based access control reduces complexity of user management and restricts access to specified time-slots. But, content privacy is still questionable in case of system resources compromise unexpectedly. Therefore, cryptographic solution for time-bound hierarchical content management is an emerging problem. Most of the related schemes focused on individual user keys and/or revocation, but not on time-bound keys. Hence, these are not well suitable for subscription-based services like pay-TV and newspaper. In this paper, we propose a cryptographic time-bound access control with constant size time-bound keys. In our scheme, subscribed time-slots embed into individual user keys to avoid periodical broadcasting of temporal keys. We prove that our scheme is selectively secure against collision attack under chosen-ciphertext attack. We then discuss cloud-based application to show the strategies of efficient revocation and reduced computational overheads for end-users. 
Structure of the space of GL4 (Z2)-coinvariants Z2 ⊗ GL4 (Z2) P H∗ (Z42,Z2) in some generic degrees and its application
Authors: Võ Phúc Đặng
Published: February 2023

 Let $A$ denote the Steenrod algebra at the prime 2 and let $k = \mathbb Z_2.$ A very difficult problem in algebraic topology is to determine a minimal set of $A$-generators for the polynomial ring $P_q = k[x_1, \ldots, x_q] = H^{*}(k^{q}, k)$ on $q$ generators $x_1, \ldots, x_q$ with $|x_1|= |x_2| = \cdots = |x_q| =  1.$ Equivalently, one can write down explicitly a basis for the cohit space $\pmb{Q}^{q} := k\otimes_{A} P_q$ in each non-negative degree $n.$ This subject, which has now a long history, is the content of the classical "hit problem" proposed in [Abstracts Papers Presented Am. Math. Soc.  \textbf{833} (1987), 55-89]. Furthermore, it is closely related to the $q$-th transfer homomorphism $Tr_q^{A}$ constructed by William Singer in [Math. Z. \textbf{202} (1989), 493-523]. This $Tr_q^{A}$ passes from the space of $G(q)$-coinvariant $k\otimes _{G(q)} P_A((P_q)_n^{*})$ of $\pmb{Q}^{q}$ to the $k$-cohomology group of the Steenrod algebra, ${\rm Ext}_{A}^{q, q+n}(k, k),$ where $G(q)$ denotes the general linear group of degree $q$ over the field $k,$ whereas $P_A((P_q)_n^{*})$ is the primitive part of $(P_q)^{*}_n$ under the action of $A.$ Particularly, Singer conjectured that $Tr_q^{A}$ is a monomorphism, but this remains unanswered for all $q\geq 4.$ Accordingly, the aim of the present study is to deal with the Singer conjecture for rank 4 in certain internal degrees. Specifically, by the usage of the techniques of the hit problem in four variables, we explicitly determine the structure of $k\otimes _{G(4)} P_A((P_4)_{n}^{*})$ in some generic degrees $n.$ Then, applying these results and a representation of $Tr_4^{A}$ via the lambda algebra, we state that Singer's conjecture is true for rank $q = 4$ in respective degrees $n.$ This has contributed to the final proof of Singer's conjecture in the rank 4 case.
Assessment of humoral immunity to SARS-CoV-2 by a sample examination of medical workers in a large specialized multidisciplinary hospital
Authors: Murzina Alyona A. , Borisova Olga V. , Kalnin Igor B. , Medvedeva Evgenia A. , Marin German G. , Kaira Alla N.
Published: February 2023

Introduction. The assessment of specific IgG antibodies to RBD Spike SARS-CoV-2 and their quantitation permit to calculate the intensity of immunity to COVID-19, i.e. to determine the level of immunity to infection, the risk of infection, the severity of the disease, as well as the ability to prevent death. Meanwhile, the protective level of antibodies is not determined. Therefore, determining the nature of immunity and quantitation of IgG antibodies to RBD Spike SARS-CoV-2 make it possible to assess the effectiveness of preventive measures and correct them in a timely manner.
The aim is to determine the presence of IgG antibodies to RBD Spike SARS-CoV-2, their concentrations, and the nature of humoral immunity in different age and occupational groups of employees in a closed-type hospital after the completed vaccination with "Gam-Covid-Vac" vaccine.
Materials and methods. The blood sera of 310 members of medical staff who received a full course of immunization with the "Gam-Covid-Vac" vaccine were tested using "SARS-CoV-2-ELISA-IgG" kit according to instructions provided in 21.20.23-004-28597318-2020, RU No. RZN 2021/15898. IgG antibodies to RBD Spike SARS-CoV-2 were quantitated against WHO standard NIBSC 20/136.
Results. Specific IgG antibodies to RBD Spike SARS-CoV-2 were found in 92.9% of the examined individuals, including 67.4% having hybrid immunity (both vaccine- and infection- induced), and 25.5% having post-vaccination immunity after immunization with the "Gam-Covid-Vac" vaccine; 7.1% participants were nonimmune. A higher level of IgG antibodies to RBD Spike SARS-CoV-2 was detected in the group of individuals with hybrid immunity (p 0.01). Only 11.6% of employees had a protective antibody level of more than 300 BAU/ml.
Discussion. Most employees with hybrid immunity were identified in the older age groups and in the junior medical staff. The results of this serological study, taking into account the age and professional aspects, can serve as the basis for adjusting preventive measures in medical institutions.
Gut microbiota and carcinogenesis in various human organs
Authors: Kostin Roman K. , Malyugin Dmitriy A. , Solenova Liya G. , Kulaeva Elizaveta D.
Published: February 2023

Scientific research in recent years has revealed a significant role of the human microbiome in carcinogenesis. These data served as a rationale for the inclusion of polymorphic microbiomes in the key characteristics of carcinogenesis as an important mechanistic determinant of cancer, in addition to other fundamental biological processes manifested during multi-stage carcinogenesis. The microbiome of the gastrointestinal tract is most actively involved in the pathogenesis of malignant neoplasms of the digestive system due to changes in the quantitative and qualitative composition of the microbiota, and increase in the production of genotoxic bacterial metabolites as factors of carcinogenesis. This review also addresses the changes in the microbiome in lung cancer, associated mainly with the production of short-chain fatty aicids, and in breast and endometrial cancers with specific changes in the composition of the bacterial community towar)ds species involved in the metabolism of estrogen precursors. The probable mechanisms of microorganisms participation in the development of prostate cancer (the effect of lipopolysaccharides, antibiotics and deconjugated estrogen) are considered.
Data on the relationship between the composition and metabolic characteristics of the microbiome in various cancer sites open up perspectives for its use in the diagnosis, treatment and prevention of malignant neoplasms and justify the need for further research in this area.
Increasing the immunogenic and protective activity of the vaccine strain Yersinia pestis EV line NIIEG using synthetic immunomodulators
Authors: Goncharova Anastasiya Yu. , Bugorkova Svetlana A. , Shchukovskaya Tatyana N.
Published: February 2023

Introduction. One of the main tasks of specific plague prevention remains the development of vaccines and their application schemes aimed at improving the effectiveness of vaccination through the use of adjuvants and immunomodulators.
The purpose of the study were comparative evaluation of the effect of drugs from the group of synthetic immunomodulators on the immunogenic and protective properties of the Yersinia pestis EV line NIIEG vaccine strain in model animal experiments.
Materials and methods. White mice and guinea pigs were immunized with the vaccine strain Y. pestis EV line NIIEG. The animals of the experimental groups were injected with oligopeptides O1 (Threonyl-glutamyl-lysyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamyl-lysyl-glutamate), O2 (Glutamyl-cysteinyl-glycine disodium) and O3 (Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine) one hour before vaccination or three times before infection. On days 3, 14 and 21, antibody and cytokine products were studied. Animals were infected with the test strain Y. pestis 231(708) at a dose of 400 LD50.
Results. It was found that a single administration of immunomodulators 1 hour before vaccination did not change the susceptibility of animals to the plague microbe: ImD50 = 5860 (O1); 5860 (O2); 6454 (O3) and 6876 (control) CFU for white mice and 446 (O1), 551 (O2), 446 (O3) and 578 (control) CFU for guinea pigs. Three-time administration of drugs to vaccinated animals led to a decrease in the ImD50 Y. pestis EV line NIIEG indicators in the group with O1 by 2.2 times (mice) and 1.8 times (guinea pigs), with O2 and O3 by 1.2 times, regardless of the biomodel compared with the control. The stimulating effect of O1 and O3 on the production of antibodies to F1 of the plague microbe and cytokines interferon-gamma, interleukin-10 has been established.
Conclusion. The stimulating potential of synthetic immunomodulators on the immune system of biomodels immunized by Y. pestis EV line NIIEG has been demonstrated, which determines the prospects of research to improve the schemes of prophylactic vaccination against plague.
Sequence analysis of the non-coding control region of John Cunningham virus isolates from patients with multiple sclerosis treated with natalizumab
Authors: Tyumentseva Marina A. , Tyumentsev Aleksandr I. , Zakharova Maria N. , Askarova Lola S. , Simaniv Taras O. , Piradov Mikhail A. , Akimkin Vasily G.
Published: February 2023

Introduction. The John Cunningham virus (JCPyV) causes a fatal demyelinating disease of the central nervous system known as progressive multifocal leukoencephalopathy (PML). In healthy people, the JCPyV non-coding control region (NCCR) is not rearranged, while NCCRs in immunocompromised patients are characterized by frequent rearrangements and can be associated with PML development. Therefore, patients treated with natalizumab, which decreases the migration of leukocytes and monocytes through the blood-brain barrier to inflammatory foci, are at increased risk of developing PML.
The purpose of the study was to analyze NCCR sequences of JCPyV isolates from patients with multiple sclerosis (MS) treated with natalizumab.
Materials and methods. A total of 26 blood plasma samples and 8 cerebrospinal fluid samples were analyzed using nested PCR to study the JCPyV NCCR structure in Russian MS patients treated with natalizumab. The NCCRs present in the samples were cloned and sequenced by Sanger sequencing. All the JCPyV NCCR sequences were compared with the archetype sequence and mapped. The NCCR sequences were also examined for presence of putative transcription factor binding sites.
Results. A total of 48 NCCR sequences were found. The analysis showed that up to 55% of NCCRs were identified as rearranged NCCRs, while the other were archetype-like NCCRs. All the sequences can be divided into 6 types with one dominant rearrangement pattern. This rearranged NCCR was also found in a patient with the confirmed PML diagnosis and a poor prognosis. All the rearranged NCCRs were characterized by the presence of additional transcription factor binding sites.
Conclusion. The study has helped identify previously unknown NCCR patterns typical of MS patients treated with natalizumab in Russia, thus confirming the need for the further research on NCCR rearrangements in MS patients undergoing natalizumab treatment to gain better understanding of the origin of neurovirulent JCPyV variants.
Opportunistic microbiota of breast milk and antimicrobial activity of milk whey at different periods of lactation
Authors: Arzumanyan Vera G. , Kolyganova Tatiana I. , Vartanova Nune O. , Ozhovan Irina M. , Kravtsova Elena O. , Zverev Vitaly V.
Published: February 2023

Object of study. The evaluation of the interaction between breast milk opportunistic microorganisms abundance and the milk whey antimicrobial activity at different periods of lactation.
Materials and methods. 100 samples of breast milk from healthy breastfeeding mothers were inoculated on solid selective media, and then pure cultures of microorganisms were identified by MALDI-TOF mass spectrometry. The antimicrobial activity of the whey against a model culture of Candida albicans was evaluated by spectrophotometry.
Results. 270 isolates represented by 36 species of 13 genera of opportunistic bacteria were obtained. None of the 100 samples contained opportunistic fungi. Staphylococci (7 species) and streptococci (11 species) were predominant. The most common were staphylococci S. epidermidis (70.2%) and S. aureus (20.8%), and streptococci S. mitis (27.7%) and S. oralis (21.8%). The total contamination (median) of opportunistic bacteria in the colostrum was 79 103 CFU/ml, transitional milk 4 103 CFU/ml, mature milk 5 102 CFU/ml. The antimicrobial activity of colostrum whey was 87.489.4%; transitional milk 88.2%; mature milk 63.481.9%. The total contamination had a high inverse correlation with the lactation period (r = 0.806) and a high positive correlation with the antimicrobial activity of whey (r = 0.699). Meanwhile, a significant decrease in contamination was noted after 1 month from the beginning of lactation, while a significant decrease in antimicrobial activity was observed after 8 months.
Conclusions. The decrease of the breast milk contamination by opportunistic bacteria during the lactation period was found to be primary compared to the decrease of the whey antimicrobial activity. Thus, changes in the whey antimicrobial protection factors occur in response to changes of the opportunistic microbiota abundance.
Makeup and marquinha: aesthetics of the bodily surface in Rio de Janeiro
Authors: Novacich Samuel
Published: February 2023

This chapter focuses on two aesthetic practices on the urban periphery of Rio de Janeiro, Brazil. First, I discuss applications of bright, deliberately eye-catching makeup in the context of professional makeup salons, among amateur enthusiasts, and in relation to women’s empowerment classes at a community center in a small favela located in Rio’s downtown. Second, I describe a tanning practice known as marquinha (little mark), in which strips of tape are applied to the body and used to create precise tan lines. Taking as a starting point the assertion that aesthetics and political dynamics are inextricably entwined, I draw comparisons between these aesthetic practices and their relation to questions of sexuality and desire, power and self-empowerment, and to questions of race. In Rio de Janeiro, as elsewhere, aesthetics are particularly important to the politics of inequality that define the urban landscape. And while aesthetics may often express ideas and indeed “say something” about their practitioners, they are hardly just passive reflections of society. This chapter focuses instead on the pragmatic power of makeup and marquinha to “causar” (to cause) and make real material impacts on viewers. In describing these practices as pragmatic, I call attention to aesthetics as a relational practice that mediates between the self and other, and invites new social possibilities. As such, makeup and marquinha are understood as co-constitutive of the contexts within which they are found, shaping not only relations between individuals and things, but also, one’s understanding of the self.
Of the spaces between: prepositional events throughout the Festival de Marseille
Authors: Kimmel Anna Jayne
Published: February 2023

This chapter considers the Festival de Marseille-danse et arts multiple 2017 as a successful apparatus of transition from positions of non-place to place in one of Europe’s most diverse cities. Through its temporary installation, the festival crossed spatial, aesthetic, and thematic divisions of the center and periphery, constructing bridges of movement between these invisible borders. In doing so, this chapter troubles the traditional affirmation that the value of performance is most prominently interpreted during its enactment. Instead, it leverages the spatial turn of French theory to emphasize that the festival's significance extends to the process of coming-to-stage, and highlights participant interactions with the city as facilitated by the festival’s infrastructure. In re-framing the boundaries of the festival’s intended performance scene from the aestheticized proscenium to the larger social context of Marseille, a voyeuristic and objectifying gaze is removed from the staged bodies and redirected to a new embodied praxis of inclusion and exclusion, rehearsed for, and by, the performer whose ephemeral offering is too often pushed to the periphery or essentialized at the center but never allowed full placement. To move away from accentuating the fixed nouns and verbs of place in a recapitulation of the actors and how they danced, this chapter instead looks toward the mechanisms that scaffolded the relationship between the two—the grammar of the event—which both exceeded and preceded its actual content. What emerges is an attention toward prepositional events, the mechanics of societies that facilitate and articulate such relations.
Gurgaon: Unfinished City, a photographic essay
Authors: Khare Sarth
Published: February 2023

As Gurgaon expands horizontally and vertically, it continues to transition from farms to urban villages to a concrete maze. This photographic project documents the growth of Gurgaon a city recently developed near India's capital, Delhi. It is a booming financial and industrial center, home to most Multinational Corporations (MNCs) and has third highest per-capita income in India. As its advocates often like to point out, Delhi’s booming neighbor has 1,100 high-rises, at least 30 malls and thousands of small and big industries. On the other hand, as its detractors unfailingly like to note, the dust bowl’s population has grown two and a half fold, it has 12-hour power blackouts, and its groundwater would probably not last beyond this decade. Gurgaon's transformation began sometime around 1996, with the advent of Genpact, then a business unit of General Electric. Other multinational companies followed it slowly thereafter. It helped that the city was a few kilometers away from Delhi. Two decades on, Gurgaon is already "on its deathbed." From 0.8 million in 2001, the city is expected to reach a population of 6.9 million in 2031. It is speckled with glass buildings with curtain walls, and swish apartment blocks with Greco-Roman influences, but there is little water or power for them. These numbers alone don’t capture the lived reality of Gurgaon, though. The skyline that its older residents were accustomed to has completely disappeared. And yet on the periphery, one sees the "Unfinished City" growing. The landscapes and flora shouting; their sentiments brutalized by evictions and concrete. Slaughtered farms now seem witness to monstrosity with desolate faces and fading memories. Set in 2014 the project explores the ephemerality of Gurgaon’s glamor and defective town planning. Families had been displaced, laborers’ children were growing up on heaps of cement, and farmlands had turned into things of memories.
The influence of N95 and FFP2 masks on cardiorespiratory variables in healthy individuals during aerobic exercise: a systematic review and meta-analysis
Authors: Lucas da Silva Lima1,2 Gustavo , Casali Rocha1,2 Thiago , Pereira de Lima da Silva Júnior3 Gilmar , Tarcísio Martins1,2 Marcelo
Published: February 2023

Objective: In view of the current COVID-19 pandemic, the objective of this study was to determine, through a systematic review and meta-analysis, whether the use of N95/FFP2 masks during aerobic exercise has a significant impact on HR, RR, SpO2, and blood pressure (BP) in healthy individuals. Methods: We searched the MEDLINE database for studies published in English between 2005 and 2021. To reduce bias and increase reliability, only randomized controlled trials and randomized crossover clinical trials were considered for inclusion. The selected outcomes included HR, RR, SpO2, and BP, with perceived exertion being evaluated by means of the Borg scale. Results: Eight controlled trials were included in the meta-analysis. Seven evaluated HR (p > 0.05), five evaluated RR (p > 0.05), five evaluated SpO2 and BP (p > 0.05 for both), and six evaluated perceived exertion, presenting controversial results such as risk ratios that were grouped for each variable. Conclusions: This study suggests that N95 and FFP2 masks do not have significant effects on HR, RR, SpO2, and BP during aerobic exercise in healthy individuals.
THE EFFECT OF MINERAL ADDITIVES ON THE PHYSICAL AND MECHANICAL PROPERTIES OF REINFORCED ORGANIC MINERAL SOILS
Authors: Borisov A. Ye. , Kanishchev A. N. , Kozlov V. A.
Published: February 2023

Statement of the problem. The aim of the work is to study the effect of mineral additives on the physical and mechanical properties of Portland cement-reinforced soils with a high humus content, as well as to assess the possibility of using these soils in road construction. Results. In the course of the study, the values of the strength and the coefficient of frost resistance of organic and mineral soil compositions with the content of humus substances reinforced with a mineral binder with the addition of sand in different proportions were determined. To compare the effect of mineral binders (cement) and an additional (polymer additive) on the structure of the resulting material, cement was used both in pure form and cement in combination with a polymer additive. The use of sand as a structural aggregate makes it possible to apply a soil with a high content of humus substances, reinforced with binding materials, in the structures of road clothes. Conclusions. Various compositional compositions of soil strengthening with the use of Portland cement as binders, polymer additives, slaked lime using sand as a mineral filler are proposed. The reinforced soil, depending on the area of application, can be used as a base of a transitional type of pavement and an additional layer of a lightweight type of pavement base, which will reduce transport costs for the delivery and payment of road construction materials.
ASSESSING THE INFLUENCE OF COMMUNITY PARTNERSHIP IN MONITORING AND EVALUATING COMMUNITY SAFETY IN LAMU WEST SUB-COUNTY
Authors: Madoya Micah  , Dr. George Wagah  , Dr. Isabella Asamba
Published: February 2023

Though community policing elements such as community partnership have been mentioned as possible CP elements that can influence monitoring and evaluation of community safety, there is limited research to ascertain this in Lamu West Sub County. The purpose of this study was to establish the effect of community partnership in monitoring and evaluating community safety in Lamu West Sub-County. The study adopted quantitative design where data was collected from a sample of 405 respondents drawn from 32,873 of Lamu West Sub-County residents with the aid of a questionnaire. Correlation and regression analyses were adopted in data analysis to help in establishing the relationship between the dependent and independent variables. The findings of this study demonstrated that there was statistically positive relationship between community partnership and in monitoring and evaluating community safety in Lamu West Sub-County at (β=0.619; p<0.05). The study found that community has been in the forefront of collaborating with the police. The study also shows that there was need for a partnership between police and the community for a sustained peace and harmony in the society. Majority of respondents agreed that partnering with the police has enabled easy identification of criminal activities. The study concludes that community partnership significantly influences monitoring and evaluating community safety. The study recommends that effective collaborations between law enforcement and community stakeholders are critical to public safety, and it is critical that government agencies, community organizations, nonprofits, companies, and private citizens all see public safety as a shared duty. There is need for more involvement of all key stakeholders in maintaining security.
KEY WORDS: Community Partnership, Monitoring and Evaluating, Community Safety
Who is to blame when we fly too close to the sun – academia or the individual?
Authors: Field Sarahanne , Devine Sean
Published: February 2023

We should beware of using Ariely and others as scapegoats. Rather than dwelling on the moral failings of individual researchers, we might reframe fraud and misconduct as a systemic problem.
Not all that shines is Diamond: why Open Access publication favours rich authors, prestigious universities and industry-funded research
Authors: Hobma Marcel
Published: February 2023

More and more researchers pay processing costs for publishing in Open Access, but these costs disadvantage authors who are female, early in their career, or from low-income countries.
Malnutrition and Pneumonia among Under-five Children in Sadewa Maternal and Child Hospital, Yogyakarta, Indonesia
Authors: Nanda Myggi Rizdwike
Published: February 2023

Background: Pneumonia is one of the top causes of morbidity in children younger than 5 years old. In Indonesia, pneumonia was the second leading cause of death in children under five years in 2017. The most important risk factors for pneumonia in children are malnutrition, household air pollution, non-exclusive breastfeeding, low birth weight (2500 g), overcrowding (≥ 7 or more person in the same household), and lack of measles immunization. This study aimed to determine the relationship between nutritional status and pneumonia in under-five children in Sadewa Maternal and Child Hospital, Yogyakarta, Indonesia.

Methods: Analytical observational studies with a cross-sectional approach. A total of 191 subjects took part in the study. Observations of the nutritional status and degree of pneumonia were carried out in this study. Univariate and bivariate data analysis was carried out with the help of SPSS version 25 software.

Results: The majority of study subjects with pneumonia had normal nutritional status. Meanwhile, study subjects with severe pneumonia conditions had malnutrition nutritional status. The results showed that nutritional status was associated with pneumonia, with a p-value of < 0.05.

Conclusion: There is a relationship between nutritional status and the severity level of pneumonia in children under five years old in Sadewa Maternal and Child Hospital, Yogyakarta, Indonesia.
Study of Different Estimation Techniques for a Micro-Phasor Measurement Unit Implementation
Authors: Bentarzi Hamid , Mahboubi Meriam , Ouadi Abderrahmane
Published: February 2023

Distribution power networks are very complex, due to the great number nodes, short distances, and small amplitude and phase angle differences between nodes, faster dynamics and lack of standard documentation. Thus, these complexities have raised the need to develop new Phasor Measurement Unit (PMU) called Micro-Phasor Measurement Unit (μPMU) with high accuracy and high precision. In this work, several estimation techniques have been investigated so far for improving effectiveness and accuracy of this micro-PMU.
BOUNDS AND PROPERTIES OF LCD CODES OVER FIELDS
Authors: Gannon S. , Kulosman H.
Published: February 2023

In 2020, Pang et al. defined binary $\text{LCD}\; [n,k]$ codes with biggest minimal distance, which meets the Griesmer bound [1]. We give a correction to and provide a different proof for [1, Theorem 4.2], provide a different proof for [1, Theorem 4.3], examine properties of LCD ternary codes, and extend some results found in [6] for any $q$ which is a power of an odd prime.