bluuebunny/crossref_metadata_2025 huggingface dataset:
RARE CASE OF FRONTAL BONE HEMATOGENIC OSTEOMYELITIS, COMPLICATED BY FOREHEAD PART BRAIN ABSCESS
Authors: Il`inykh A S , Larin A I , Bocharov A A , Bobrovskaya A N , Durov O V , Safin A V
Published: March 2018

Osteomyelitis of skull belongs to the rare necrotic infections of bones. Its distribution is about1.5% from osteomyelitis of the flat bones. During last 10 years in Russian neuro-surgical literature are no data covering this issue. Foreign publications review observations about single cases. This work describes clinical case of successful surgical treatment of frontal bone osteomyelitis, complicated by abscess in forehead part of brain.
STAGE TREATMENT OF CELIAC TRUNK COMPRESSION SYNDROME (Case report and literature review)
Authors: Chupin A V , Orehov P Yu , Lebedev D P , Parshin P Yu , Lesnyak V N , Kemezh Yu V , Bakulina I F
Published: March 2018

Report and literature review of the rare disease – celiac trunk compression syndrome are presented. We discuss as typical manifestations of disease, and the most controversial aspects of the pathogenesis, diagnosis and treatment. We propose a diagnostic algorithm for early detection of the disease, and show that to achieve a good effect, may be required several stages of intervention. With the accumulation and codifying of experience it is possible to develop a more detailed indications to different types of surgery.
THYROID MALIGNANCY IN THE PRACTICE:THE RELEVANCE AND COMPLEXITY OF THE PROBLEM
Authors: Smirnov V V , Zamyatina O V
Published: March 2018

The review considers the problem of diagnosis and differential diagnosis of nodular thyroid neoplasms. It is given current classification, discussed the clinical and technological approaches to verify the diagnosis.
RECURRENCE OF TACHYCARDIA IN 8 YEARS AFTER RADIOFREQUENCY CATHETER ABLATIONOF SLOW PATHWAY OF ATRIOVENTRICULAR JUNCTION
Authors: Himiy O V , Zhelyakov E G , Konev A V , Ardashev A V
Published: March 2018

In the article the clinical case of recurrence of typical atrioventricular nodal reentry tachycardia (AVNRT) in 8 years from the moment of a radiofrequency catheter ablation of slow pathway of atrioventricular junction concerning paroxysmal AVNRT at the patient of 42 years is described.
PLASTIC OPERATIONS FOR THE FACE AND NECK AFTER BURNS
Authors: Sharobaro V I , Moroz V Yu , Yudenich A A , Vaganova N A , Grechishnikov M I , Vaganov N V
Published: March 2018

Discussions so far continue about optimal terms and methods for plastic operations on face and neck after burn injuries that is necessary for reduction the time of medical rehabilitation of burned patients. In the given work authors' view at this problem based on the experience of treatment of more than 800 patients is presented. The expediency of correct timing of plastic operations and features of techniques is proved for achievement of optimal aesthetic and functional results.
STEM CELL THERAPY OF MALIGNANT BRAIN TUMORS: REALITY AND PROSPECTS
Authors: Bryukhovetskiy I S , Bryukhovetskiy A S , Mischenko P V , Merkulov I A , Khotimchenko Y S
Published: March 2018

Modern methods for the treatment of malignant brain tumors are insufficiently effective. One reason for this is that the existing technologies and methods are focused on removing all neoplastic cellsfrom the body. Understanding the mechanisms of systemic migration of stem cells provides a new view on the role of this phenomenon in the development of malignant tumors. Migration and homing of normal stem cells, being originally the regulatory process, ensuring revascularization and remodeling of ischemic or traumatic injury of brain, play a role of the axial conductor of neoplastic process in carcinogenesis. The use of the phenomenon of migration and homing of stem cells in the tumor center for therapeutic purposes opens the possibility of overcoming the blood-brain barrier, reducing the toxicity of chemotherapy and increasing the radiation therapy efficiency, makes possible the directed influence on the hypoxic zone of the tumor, can directly affect to the key life processes of tumor stem cells. These arguments allow to consider the mechanisms of systemic migration and homing of stem cells to neoplastic foci as a fundamental theoretical platform for the creation of a fundamentally new class of anti-cancer, cell personalized medicines.
THE PROBLEMS OF THEORETIC NEUROLOGY: INFORMATION-COMMUTATIVE THEORY OF HUMAN BRAIN AND PRINCIPLES OF ITS FUNCTIONING
Authors: Bryukhovetskiy A S
Published: March 2018

The article summarizes contemporary scientific concepts of brain organization and structure. For the first time we developed information principles of brain functioning and the basics of information communicative theory of brain. Here we demonstrate that information commutative organization (ICO) of brain has multilevel structure of open type represented by the block of information capture and transfer (BICT) and the block of information processing (BIP). BICT is a switchboard with information dispatcher and router in nervous tissue (NT). BICT has system vertical and complex horizontal commutation. Brain ICPs are presented as interthecal information registers (ITIRs) that provide extraneural information processing in subarachnoid space (SAS) and subdural space (SDS) above brain. The arcs of conditioned and unconditioned reflexes close in SAS extraneurally when electro-magnetic waves (EMWs) of cortical ICM subscribers are reflected from the arachnoid mater and information is automatically sent to ICM receivers of brain cortex (reflectory ITIRs). Information processing (analysis, synthesis, calculations) is based on dissipation of EMWs of cortical NT ICMs in SAS and SDS cerebrospinal fluid (CSF) forming support and object EMWs, which, being reflected from the arachnoid or dura mater form holograms of information images matrixes (IIMs) by interference, diffraction and superimposition while IIMs are the basics of brain cognitive functions (cognitive ITIRs). The theory of brain can become a new milestone in the development of therapies of nervous diseases, neuromorphic computation, innovative systems of artificial intellect and novel approaches to brain-computer interface.
HOW TO CONDUCT CLINICAL TRIALS OF STEM CELLS TECHNOLOGIES
Authors: Averyanov A V , Bryuhovetskiy A S
Published: March 2018

The article presents the authors' position, based on experience of clinical trials in the field of regenerative technologies on the organization of such research projects in the absence of legal regulation
THE IMPACT OF NET IMPLANTS FOR HERNIOPLASTY ON THE STATE OF REPRODUCTIVE FUNCTION
Authors: Protasov A V , Mikhaleva L M , Smirnova E D , Blokhin A V , Shemaytovskiy K A
Published: March 2018

The authors provide the results of experimental research of influence of polypropylene and polyester mesh implants on the state of the reproductive organs after simulated hernioplasty
THE ROLE OF THE PRIMARY-OUTPATIENT CARE PHYSICIAN IN TREATMENT OF PATIENTS WITH METABOLIC SYNDROME
Authors: Kirichenko L L , Ovsyannikov K V , Korolev A P , Fedoseev A N , Tochilkina S A , Dvoryanchikova Zh Yu , Ulyanova E A
Published: March 2018

Metabolic syndrome is attracting more and more attention of physicians because of the increasing prevalence and poor prognosis for patients. The main target in treatment of any chronic disease is to achieve a satisfactory compliance status that depends on the motivational status of a patient and a physician. Communication between some aspects such as the motivation to conduct long-term therapy, the level of knowledge and readiness to use both of these parts on practice is interest to explore.The aim of the present study was to analyse the readiness of primary care physicians to assist patients with the metabolic syndrome. Tasks that the authors set for themselves, was to assess the knowledge, skills and willingness of primary care physicians to help patients with metabolic syndrome. The object of study were physicians and local therapists working in Moscow hospitals and clinics, who were training at the Department of Therapy №2 FPGE MSMSU from 2011 to 2013. Surveys were conducted on the basics of the available methodologies for assessing the knowledge and skills that are using in teaching nowadays. Analysis of the results suggests very low willingness of physicians to assist patients of this category.
THE СOMBINATION OF SPINAL SUBARACHNOID HEMORRHAGE AND MIELOISHEMIA: DIFFICULTIES OF DIAGNOSIS AND PECULIARITIES OF NEUROREHABILITATION
Authors: Bobrovskaja A N , Lobanov S A
Published: March 2018

The article contains the description of the clinical case of rare combination of spinal subarachnoid hemorrhage end mieloishemia in 50-year-old patient, with discussion of difficulties of diagnosis and peculiarities of neurorehabilitation.
SUDDEN CARDIAC DEATH IN PATIENTS WITH DILATED CARDIOMYOPATHY
Authors: Duplyakov D V , Kondratyeva I V , Garkina S V
Published: March 2018

The review discusses accumulated to date scientific data on dilated cardiomyopathy: causative factors, clinical manifestations, sudden cardiac death in patients with the disease and its risk-stratification in the light of National guidelines on the definition of risk and prevention of sudden cardiac death (2012). A case of a patient with dilated cardiomyopathy and high-risk of sudden cardiac death is presented.
SUDDEN CARDIAC DEATH AND METABOLIC SYNDROME
Authors: Yavelov I S
Published: March 2018

In the review epidemiologic data regarding sudden cardiac death in patients with metabolic syndrome are presented. Suspected pathophysiologic mechanisms and approaches to primary prevention of this event are considered.
VENTRICULAR ARRHYTHMIAS IN PATIENTS WITHOUT STRUCTURAL HEART DISEASE
Authors: Yakovleva M V
Published: March 2018

Risk stratification of ventricular tachyarrhythmia in patients without structural heart disease is still one of the most important question that requires the answer. We now demonstrate our attempt of risk stratification for this group of patients, taking into account their anamnestic and history data and instrumental research results.
THE ULTRASTRUCTURE OF BIODEGRADABLE IMPLANTS: CHANGES DURING THE TIME
Authors: Akhpashev A A , Dzhambinova E A , Kanaev A S , Agzamov D S
Published: March 2018

The authors describe in detail the biochemical processes that occur over time and with the collapse of the polymer in the bone. Originally used scanning electron microscopy to assess the condition of clamps, which spent several years in the bone. The data obtained is objective evidence that the biological activity of the implant in the bone and again emphasize the importance of the choice of materials to be implanted in the human body.
Challenges and perspeсtives of aesthetiс surgery of low limbs
Authors: Artem'ev A A , Zagorodniy N V , Ivashkin A N , Bytdaev Z M , Abakirov M D
Published: March 2018

The article is on poorly studied topic of surgical leg malalignment correction for aesthetic indications. These operations must be carried out efficiently, with minimal complications.The article is a review of publications, demonstrates the possibilities of current techniques of correction and outlines the indications for a particular type of surgical correction. The article presents the descriptive clinical cases of aesthetic results after varus deformity correction of the lower limbs.The purpose of this study was to evaluate the possibilities of modern types of external osteosynthesis in the leg shape correction according of the aesthetic indications. In the period from 1996 to 2014 was carried out more than 800 operations on both legs in more than 400 patients. In the majority of cases was received good and excellent results, but met serious complications - inflammation, osteomyelitis, delayed fusion. The resulting complications forced to seek new methods of correcting the shape of the feet. The use of internal fixation seems very perspective.
ONCOLYTIC VIRUSES IN HIGH-GRADE GLIOMAS TREATMENT
Authors: Baklaushev V P , Goryainov S A , Potapov А А , Pavlova G V , Chehonin V P
Published: March 2018

The review examines the state of the art of diagnosis and therapy of high-grade gliomas both by currently existing clinical guidelines, and from the point of view of the most promising approaches of currently undergoing laboratory tests and the first clinical trials. One of the most promising approach for the treatment of malignant gliomas is the nonpathogenic oncolytic viruses (OV) application. The data of preclinical trials of OV and the first preliminary results of clinical trials are discussed.
MOLECULAR GENETIC APPROACHES IN THE DIAGNOSIS OF LUNG CANCER
Authors: Khodyrev D S , Nikitin A G , Kulagina N S , Averyanov A V
Published: March 2018

It is an acute problem for the 21st century to find effective and inexpensive methods for early detection of lung cancer. Patients, suspected of having a malignant disease of lungs, generally undergo clinical studies such as CT scans of the chest and bronchoscopy. The latter is mainly used to confirm the diagnosis. However, even when the signs, symptoms and radiological findings indicate that clinical diagnosis of malignant lung disease is evident, additional invasive procedures for obtaining the biological material suitable for the final confirmation of the presence of malignant cells are required. Currently, there is a clear understanding of the need to find biomarkers able to detect pre-clinical stage of cancer cells using minimally invasive procedures.
CLINICAL AND MORPHOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF THE CONTENTS OF PD-ECGF, TGF-β, KI67 IN ENDOMETRIUM AT LARGE UTERINE LEIOMYOMA
Authors: Askolskaya S I , Kogan E A , Popov Yu V , Solomakhina M A , Fayzullina N M
Published: March 2018

The endometrium may be the most convenient object of forecasting the development of the large uterine fibroid, as the object is available in the diagnosis of diseases of the uterus, changes in its cytokine profile linked with the growth of uterine fibroid. Immunohistochemically identification of high expression of Ki 67, TGF-, PD-ECGF in the endometrium allows to predict the development of large uterine fibroids.
USE OF AN AQUEOUS SOLUTION «PHOTODITAZIN», COMPLEXED WITH A VARIETY OF POLYMERS FORTHE TREATMENT OF PURULENT WOUNDS OF SOFT TISSUE EXPERIMENT
Authors: Solovyeva A B , Spokoyniy A L , Rudenko T G , Shekhter A B , Glagolev N N , Aksenova N A , Baranov A V
Published: March 2018

The article presents the results of a study of water-soluble polymers effects on the “Photoditazin” activity and the course of wound process under photodynamic therapy of purulent wounds in rats. The data of macroscopic and histological study of wounds status before and after photodynamic therapy, and assessed the quality and degree of intensity of reparative processes under influence of photodynamic therapy with the drug “Photoditazin” and its complexes with water-soluble polymers of natural poly- saccharide chitosan and a triple block copolymer of ethylene- and propylene oxide (pluronic F127).It was given the rationale for Pluronic F127 joining to the drug “Photoditazine” for reducing the cytotoxic effects of the drug.
RETROPERITONEAL SCHWANNOMA (CLINICAL CASE)
Authors: Stepanova Yu A , Grishankov S A , Karelskaya N A , Kalinin D V , Glotov A V
Published: March 2018

Schwannoma - a tumor growing from Schwann cells of the peripheral nerve sheath. Retroperitoneal schwannoma is a rare tumor accounting for approximately 1 to 5% of all retroperitoneal neoplasms. Retroperitoneal localization occurs for a total in 0.75-2.6% of cases, often they localize in the extremi- ties, the head and neck. Despite the significant progress made currently in the field of instrumental studies for non-organ retroperitoneal tumors, diagnosis and differential diagnosis remain a complex problem requiring further study. Presented clinical case illustrates difficulties in the diagnosis of retro- peritoneal schwannoma. Precise preoperative determination of the tumor relationship with all the nearby organs and vessels according to the different methods of ray diagnostics gives an opportunity to define the tactics of treatment.
THE ADVANTAGES OF USING PROXIMAL FEMORAL NAIL ANTI-ROTATION (PFNA) WITH THE AUGMENTATIONIN THE OSTEOSYNTHESIS OF HIP FRACTURES ON BACKGROUND OF OSTEOPOROSIS
Authors: Zagorodny N V , Volna A A , Panfilov I I
Published: March 2018

We analyzed the results of one-stage correction of the asymmetry of mammary glands in 51 patients with a diagnosis of hypomastia. On the basis of obtained results the algorithm of one-stage restoration of symmetry at the given category of patients, based on the type and severity of the asymmetry was developed, which contributes to the achievement of good aesthetic results in 94.1% of cases.
ASSESSMENT OF AGE-RELATED CHANGES OF MYOCARDIAL CONTRACTILITY OF THE LEFT VENTRICULAR BY SPECKLE-TRACKING ECHOCARDIOGRAPHY AND DETERMINING THEIR RELATIONSHIP WITH TELOMERE LENGTH
Authors: Plokhova E V , Akasheva D U , Tkacheva O N , Strazhesko I D , Dudinskaya E N , Kruglikova A S , Pykhtina V S , Streltsova V I , Boitsov S A
Published: March 2018

Purpose: The aim of this cross-sectional study was to explore a profile of left ventricular (LV) strain parameters in healthy older and to examine their association with telomere length - accepted marker of cellular senescence.Methods: Echocardiography and 2-D speckle tracking analysis was performed on 303 healthy volunteers aged 23 to 91 years without history of cardiovascular diseases (CVD). LV myocardial deformations were obtained using off-line analysis program QLAB (Philips). Telomere length was measured in peripheralblood mononuclear cells by a real-time quantitative polymerase chain reaction method.Results: Global longitudinal LV strain was reduced in older people without CVD. Radial strain of LV, apical and basal rotation, LV systolic twist were increased (p<0,001). There are no association with circulation LV strain. Telomere length was not associated with the longitudinal LV strain (β=-0.117, p=0.5). However, a significant relation was obtained with LV twist (β=-0.518, p=0.03). Short telomeres enhances the risk of increasing LV twist in 2 times (χ2=3,99, p=0,05; OR=1,96; 95% CI 1,01-3,79).Conclusion: Longitudinal strain decreases in older people. Radial strain and LV twist increases with aging. These changes indicate the age-related disorders of myocardial contractility and may be considered as a markers of biological age of heart. Increase in LV twist is significantly associates with telomere length, allowing use these parameters as markers of biological age. Cellular senescence has an independent contribution to the age-associated changes in the contractile function of the LV myocardium.
PECULIARITIES OF STRUCTURAL-FUNCTIONAL STATE OF THE KIDNEYS ACCORDING ELASTOGRAPHY SHEARWAVE IN CHILDREN WITH ARTERIAL HYPERTENSION ON THE BACKGROUND OF OBESITY
Authors: Borsukov A V , Bekezin V V , Kozlova E U , Zuy V S
Published: March 2018

Introduction. Metabolic and hemodynamic consequences of obesity (insulin resistance and hyperglycemia, hypertension, dyslipidemia) rofm metabolic syndrome in adolescence and an accordingly high risk of cardiovascular morbidity and mortality in adulthood. In recent years, studies have shown that obesity and metabolic syndrome are independent risk factors for chronic kidney disease (CKD). Ultrasonography is the most commonly used noninvasive method for research of the kidneys in pediatric patients.Aim of the study: to assess new features of shear wave elastography for the diagnosis of structural-functional state of the kidneys in children with arterial hypertension and obesity. Materials and methods. Ultrasound examination of kidneys was performed using a digital portable ultrasound system ANGIODIN - sono / P - Ultra (NPF “BIOS” Russia). Was examined 83 children who underwent elastography shear wave parenchymal layer of the kidney definition of renal parenchymal stiffness in kPa.Results. In patients with arterial hypertension and obesity the results of elastography, shear waves we found significant differences in the elasticity of the renal parenchyma between those with arterial hypertension (group 1, n=37) and children with uncomplicated obesity (group 2, n=26). The elasticity of the renal parenchyma in patients of the control group (n=20) was significantly lower than in patients of the 1st and 2nd groups. The results show that in children of the 1st group with stable hypertension high values of the elasticity of the renal parenchyma were detected in 3,2 times more often in comparison with children of the 1st group were diagnosed with labile hypertension. Conclusion. The shear wave elastography is an informative noninvasive method of evaluation of the kidneys in children with arterial hypertension with obesity. This diagnostic approach can be used in pediatric patients as a screening method (before ABPM) to assess the risk of developing hypertension, degree of hypertension and the adequacy of current anti-hypertensive therapy.
ANALYSIS OF GENE METHYLATION SHOX2, TGFBR1, MIR-375 IN DIFFERENT TYPES OF LUNG CANCER
Authors: Khodyrev D S , Kulagina N S , Brovkina O I , Pokrovsky V E , Gordiev M G , Кelekhsaeva A S , Nikitin A G , Averyanov A V
Published: March 2018

In the 21st century is an acute problem to find effective and inexpensive methods for the early detection of lung cancer. Patients suspected of having a malignant disease of the lungs, generally undergo clinical studies such as CT scans of the chest and bronchoscopy. The latter is mainly used to confirm the diagnosis. However, even when the signs, symptoms and radiological findings indicate that clinical diagnosis of malignant lung disease is evident, additional invasive procedures for obtaining the biological material suitable for the final confirmation of the presence of malignant cells. Currently, there is a clear understanding of the need to find biomarkers able to detect pre-clinical stage of cancer cells using minimally invasive procedures. In this paper, for the DNA of patients with different types of lung cancer samples, with a view to a better understanding of the causes of lung cancer pathology gene methylation analysis was conducted for SHOX2, TGFBR1 and MIR-375.
DIRECT CONSTANT HIS BUNDLE PACING: HEMODYNAMIC BENEFIT AND LONG-TERM CLINICAL PROSPECT
Authors: Zholkovskiy A V , Sklyarov F V , Chudinov G V , Ponomarev A V , Peskov N A , Tatyanchenko A A , Korshunov V V
Published: March 2018

Analysing the example of unusual case of a successful direct constant His bundle pacing, we would like to draw specialist’s attention to details of procedure and some important electrophysiological particularities we have come across during operation. Long-term (7 years) results ( pacing options, ECG data, changes of left ventricle ejection fraction and patient’s quality of life) were considered too.
CERVICAL SPINE INSOLVENT FIXATION IN THE CASES OF ITS TRAUMAS AND DISEASES
Authors: Grin A A , Kasatkin D S
Published: March 2018

The work represents the analysis of surgery treatment of 552 patients with traumas and degenerative diseases of cervical spine subaks level (CSSL) who were treated in Scientific Research Insnitute of Emergency Care n.a. N.V. Sklifosofsky neurosurgery department since 01.01.2001 to 31.12.2013 and who underwent 554 surgeries. 19 (3.4%) patients had complications connected with the incorrect installation of a stabilizing system and insolvent fixation of a spine. 5 other patients were moved from other hospitals with instrumental confirmed dislocation of ventral plate fragments and damages of the esophagus. The aim of this work is to define risk factors, frequency and causes of complications connected with unsatisfactory fixation of CSSL of patients with trauma and degenerative diseases of cervical spine subaks level.
An Interdisciplinary Population Health Approach to Radon Health Risk Management in Canada
Authors: Khan Selim M , Gomes James
Published: March 2018

Radon is a known carcinogen found in indoor air that exists at higher than the federal reference level (200 Bq/m3) in about 10% of Canadian homes. Every year, over 3,000 people die from radon-induced lung cancer, which accounts for 16% of annual lung cancer deaths in Canada. Radon is the leading cause of lung cancer deaths among non-smokers and is second among smokers. Children, women, and smokers from lower income groups are disproportionately affected. Although the Federal Government has reset the guideline (from the previous 600 Bq/m3 down to 200 Bq/m3) and provincial governments revised the building codes to limit exposure, there remain controversies with the latest scientific development in adopting strategies of radon management in Canada.

This review applies an Integrated Population Health Framework to look at the relationships and interactions between population health determinants such as biology and genetics, environment and occupation, and social and economic factors, that influence the health risk of radon. The evidence gathered supports policy analysis with the application of ethical and risk management principles that lead to the identification of efficient and affordable broad-based and population-level preventive strategies. The final inferences enhance the framework by adding critical intervention modalities to Health Canada’s National Radon Program.
Professional Bureaucracy and Health Care Managers’ Planned Change Strategies: Governance in Swedish Health Care
Authors: Andreasson Jörgen , Ljungar Erik , Ahlstrom Linda , Hermansson Jonas , Dellve Lotta
Published: March 2018

To increase efficiency and quality, process development has been implemented in many Swedish hospitals. These hospitals are usually organized as professional bureaucracies in which health care managers have limited decision control. The new governance principles has been implemented without removing bureaucratic elements. This study analyzes how managers implement planned change in these professional bureaucracies, considering if managers coaching style, organizational preconditions, implementation strategy, appraisal of change and clinic autonomy, is associated with health care process quality (HPQ). The study is based on interviews with health care managers and longitudinal assessments of HPQ. The results revealed significant differences between coaching style, organizational preconditions, and HPQ over time. The conclusion is that leadership and preconditions is of importance for the health care manager’s ability to work with planned change, as that the health care managers understand how management methods, governance principles, and professional bureaucracies work in practice.
EDUCAÇÃO COMO PRÁTICA DA LIBERDADE E A PERSPECTIVA DA EDUCAÇÃO INTEGRAL NO ENSINO SUPERIOR
Authors: Silva João Ricardo , Azebedo Brasileiro Tânia Suely
Published: March 2018

No presente artigo discutimos a ideia de Educação como Prática da Liberdade, tendo em conta uma perspectiva emancipatória de Educação Integral para o Ensino Superior. Assim, refletimos sobre uma educação integral em contraposição à versão hegemônica e simplista de uma educação para o mercado e até mesmo em contraposição àquela que significa absorção de conhecimentos objetivos superiores. A metodologia utilizada foi a pesquisa bibliográfica, onde buscamos uma síntese dinâmica entre autores/as marxistas e a discussão decolonial/pós-colonial. O horizonte teórico foi de um materialismo histórico dialético, mas sem descurar que os conhecimentos estão para além do olhar ocidental e que a ciência não é a única lógica de conhecimento válida. Tendo em vista que o conhecimento é não só reflexo da realidade, mas a interpretação deste, a busca por uma educação integral é também a busca por interconhecimento. O que nos leva a dessacralizar a universidade e a transformá-la em local de construção de relações democráticas.

Palavras-chave: Educação Integral. Práticas da liberdade. Ensino Superior.
EDUCAÇÃO INTEGRAL, TEMPO E ESPAÇO: PROBLEMATIZANDO CONCEITOS
Authors: Assis Ana Elisa Spaolonzi Queiroz , Silva Celso Mendes Ferreira da
Published: March 2018

A Educação Integral, a despeito de ser tema de agenda de política pública há algumas décadas, ainda carrega consigo disparidades referentes ao seu conceito. Nesse sentido, o presente artigo tem como objetivo problematizar não só os conceitos de educação integral, mas também as categorias tempo e espaço constantes nas revistas Em Aberto, organizadas e publicadas pelo Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), de números 80 (2009) e 88 (2012), respectivamente intituladas “Educação Integral e tempo integral” e “Políticas de educação integral em jornada ampliada”. A metodologia é pautada na análise de conteúdo de Bardin, respeitando as etapas de pré-análise (corpus da pesquisa formado pelos textos presentes nos periódicos); exploração do material (leitura dos textos com a codificação de dados escolhendo as unidades de registro para categorização); e tratamento e interpretação dos resultados, tendo como base a Pedagogia Histórico-Crítica de Saviani. O trabalho revela multiplicidade conceitual convergente e divergente, que provoca discussão sobre uma concepção crítica de educação integral.

Palavras-chave: Educação Integral. Pedagogia Histórico-Crítica. Análise de Conteúdo.
ESCOLA A TEMPO INTEIRO: DIMENSÕES DE ANÁLISE, IDEIAS E HIBRIDISMOS DE UMA POLÍTICA PÚBLICA DE EDUCAÇÃO
Authors: Pires Carlos
Published: March 2018

A ideia de escola a tempo inteiro (ETI) em Portugal está associada à missão da escola pública e ao papel do Estado na provisão da educação integral da criança/do aluno e na promoção da igualdade de oportunidades no acesso a serviços públicos de educação que garantam a eficácia e a qualidade das aprendizagens e do sistema educativo. A problematização da ETI, encarada como política pública de educação, preconiza a emergência de “novas” formas de ação educativa, de outra conceção de escola pública, que monopoliza a educação integral do aluno, e de outros modos de administração na prestação de serviços públicos de educação. A opção teórica por uma abordagem interpretativa baseada na “análise das políticas públicas” permite percecionar as ideias preconizadas e os problemas político-educativos para os quais a política de ETI é apresentada como solução construída. Esta abordagem põe em evidência a natureza híbrida dos “modelos” de implementação da política presentes nas tensões entre tendências homogeneizadoras, coercivas, centralizadoras e estatizantes e tendências descentralizadoras preconizadoras da diversidade, do princípio da subsidiariedade e da liberdade de escolha.

Palavras-chave: Escola a tempo inteiro. Escola pública. Política educativa. Análise das políticas públicas.
Converting the Literature of a Scientific Field to Open Access Through Global Collaboration: the Experience of SCOAP3 in Particle Physics
Authors: Kohls Alexander , Mele Salvatore
Published: March 2018

Gigantic particle accelerators, incredibly complex detectors, an antimatter factory and the discovery of the Higgs boson – this is part of what makes CERN famous. Only a few know that CERN also hosts the world largest Open Access initiative: SCOAP3. The Sponsoring Consortium for Open Access Publishing in Particle Physics (SCOAP3) started operation in 2014 and has since supported the publication of 19,000 Open Access articles in the field of particle physics, at no direct cost, nor burden, for individual authors worldwide. SCOAP3 is made possible by a 3,000-institute strong partnership, where libraries re-direct funds previously used for subscriptions to ’flip’ articles to ’gold Open Access’. With its recent expansion, the initiative now covers about 90% of the journal literature of the field. This article describes the economic principles of SCOAP3, the collaborative approach of the partnership, and finally summarizes financial results after four years of successful operation.
Genome-Guided Analysis of the Syntrophic Acetate Oxidizer C. ultunense and Comparative Genomics Reveal Different Strategies for Acetate Oxidation and Energy Conservation in Syntrophic Acetate-Oxidising Bacteria
Authors: Manzoor Shahid , Schnürer Anna , Bongcam-Rudloff Erik , Müller Bettina
Published: March 2018

Syntrophic acetate oxidation operates close to the thermodynamic equilibrium and very little is known about the participating organisms and their metabolism. Clostridium ultunense is one of the most abundant syntrophic acetate-oxidising bacteria (SAOB) found in engineered biogas processes operating with high ammonia concentrations. It has been proven to oxidise acetate in cooperation with hydrogenotrophic methanogens. There is evidence that the Wood-Ljungdahl (WL) pathway plays an important role in acetate oxidation. In this study we analysed the physiological and metabolic capacities of C. ultunense on genome scale and conducted a comparative study of all known characterised SAOB, namely Syntrophaceticus schinkii, Thermacetogenium phaeum, Tepidanaerobacter acetatoxydans and Pseudothermotoga lettingae. The results clearly indicated physiological robustness beneficial for anaerobic digestion environments and revealed unexpected metabolic diversity with respect to acetate oxidation and energy conservation systems., Unlike S. schinkii and Th. phaeum, C. ultunense clearly does not employ the oxidative WL pathway for acetate oxidation, as its genome (and that of P. lettingae) lack important key genes. In both those species, a proton motive force is likely formed by chemical protons involving putative electron-bifurcating [Fe-Fe] hydrogenases rather than proton pumps. No genes encoding a respiratory Ech hydrogenase, as involved in energy conservation in Th. phaeum and S. schinkii, were identified in C. ultunense and P. lettingae. Moreover, two respiratory complexes sharing similarities to the proton-translocating ferredoxin:NAD+ oxidoreductase (Rnf) and the Na+ pumping NADH:quinone hydrogenase (NQR) were predicted. These might form a respiratory chain involved in reduction of electron acceptors other than protons. However, involvement of these complexes in acetate oxidation in C. ultunense and P. lettingae needs further study. This genome-based comparison provides a solid platform for future meta-proteomics and meta-transcriptomics studies and for metabolic engineering, control and monitoring of SAOB.
A Comprehensive Study of Activity Recognition Using Accelerometers
Authors: Twomey Niall , Diethe Tom , Fafoutis Xenofon , Elsts Atis , McConville Ryan , Flach Peter , Craddock Ian
Published: March 2018

This paper serves a survey and empirical evaluation of the state-of-the-art in activity recognition methods using accelerometers. We examine research that has focused on the selection of activities, the features that are extracted from the accelerometer data, the segmentation of the time-series data, the locations of accelerometers, the selection and configuration trade-offs, the test/retest reliability, and the generalisation performance. Furthermore, we study these questions from an experimental platform and show, somewhat surprisingly, that many disparate experimental configurations yield comparable predictive performance on testing data. Our understanding of these results is that the experimental setup directly and indirectly defines a pathway for context to be delivered to the classifier, and that, in some settings, certain configurations are more optimal than alternatives. We conclude by identifying how the main results of this work can be used in practice, specifically in experimental configurations in challenging experimental conditions.
Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production
Authors: Slaine Patrick D. , MacRae Cara , Kleer Mariel , Lamoureux Emily , McAlpine Sarah , Warhuus Michelle , Comeau André M. , McCormick Craig , Hatchette Todd , Khaperskyy Denys A.
Published: March 2018

Mice are not natural hosts for influenza A viruses (IAVs), but they are useful models for studying antiviral immune responses and pathogenesis. Serial passage of IAV in mice invariably causes the emergence of adaptive mutations and increased virulence. Typically, mouse-adaptation studies are conducted in inbred laboratory strains BALB/c and C57BL/6, which have defects in the antiviral Mx1 gene that results in increased susceptibility to infection and disease severity. Here, we report the adaptation of IAV reference strain A/California/07/2009(H1N1) (a.k.a. CA/07) in outbred Swiss Webster mice. Serial passage led to increased virulence and lung titers, and dissemination of the virus to brains. We adapted a deep-sequencing protocol to identify and enumerate adaptive mutations across all genome segments. Among mutations that emerged during mouse-adaptation, we focused on amino acid substitutions in polymerase subunits: polymerase basic-1 (PB1) T156A and F740L, and polymerase acidic (PA) E349G. These mutations were evaluated singly and in combination in minigenome replicon assays, which revealed that PA E349G increased polymerase activity. By selectively engineering these three adaptive PB1 and PA mutations into the parental CA/07 strain, we demonstrated that adaptive mutations in polymerase subunits decreased the production of defective viral genome segments with internal deletions, and dramatically increased the release of infectious virions from mouse cells. Together, these findings increase our understanding of the contribution of polymerase subunits to successful host adaptation.
Análise morfométrica, bromatológica e sensorial de tilápia do Nilo vacinada contra Streptococcus agalactiae
Authors: ROCHA Rovena Lebarch , FERREIRA Julia Merlo , MIRANDA LOPES Taciana Onesorge , GOMES Levy Carvalho
Published: March 2018

O objetivo desse trabalho foi avaliar o efeito da vacinação contra Streptococcus agalactiae na morfometria, bromatologia e análise sensorial de tilápia criada em tanque-rede. Juvenis de tilápia foram criadas em tanque-rede separados em dois grupos: peixes vacinados e não vacinados. Foram coletados 10 peixes de cada grupo em diferentes classes de peso: 400-500, 501-600, 601-700 e 701-800 g. As medidas e pesagens do peixe inteiro e do filé não apresentaram diferença significativa entre os dois grupos. A espessura do filé foi significativamente maior nos peixes não vacinados na faixa de 601-700 g. Não teve diferença significativa nos valores de proteí­­na, lipí­­dio, cinza e umidade entre os peixes dos dois grupos em nenhuma das classes de peso estudada. Para o teste pareado preferência, não houve uma preferência significativa entre peixes não vacinados e vacinados independente da classe de peso analisada. A análise de escala hedônica apontou que os provadores gostaram moderadamente do filé de tilápia independente da classe de peso e de ter sido vacinado ou não. Nas condições experimentais de criação em tanques-rede, tilápias do Nilo vacinados e não vacinados, com peso entre 400 e 800 g, apresentaram caracterí­­sticas morfométricas, bromatológicas e sensoriais semelhantes.
Impacto do controle do mexilhão-dourado no custo de produção de tilápia em tanques-rede
Authors: COSTA Jesaías Ismael da , MARTINS Maria Inez Espagnoli , AYROZA Daercy Maria Monteiro de Rezende
Published: March 2018

Este trabalho avaliou o impacto econômico do controle do mexilhão-dourado na criação de tilápia-do-nilo em tanques-rede de diferentes volumes e escalas de produção. Foram selecionadas 12 pisciculturas situadas no reservatório Ilha Solteira, no rio Paraná (SP/MS), e em Canoas II e  Chavantes, no rio Paranapanema (SP/PR). As informações de desembolsos e capital necessários para calcular o custo do controle do mexilhão foram obtidas por meio de questionário apresentado aos piscicultores. Foram contabilizados os gastos com mão de obra, manutenção e depreciação da infraestrutura e equipamentos utilizados na limpeza; manutenção e depreciação adicional dos tanques-rede; e energia elétrica ou combustí­­vel gastos em serviços de limpeza. As empresas de grande porte foram as que tiveram os menores custos incrementais, independentemente do volume dos tanques-rede. A depreciação e a manutenção dos tanques-rede foram os fatores que mais impactaram o custo para o controle de mexilhão, a uma taxa média de 69,89%. O menor custo incremental foi observado nas pisciculturas de grande porte (R$ 0,45 kg fish-1), seguido das de médio e pequeno porte (R$ 1,00 kg fish-1). O impacto econômico médio foi de 11,48% (grande porte), 27,25% (médio porte) e 25,81% (pequeno porte). Considerando o volume dos tanques-rede esse impacto variou entre 7,83% em tanques de 108 m3  e 19,22% em tanques de 6 m3 .
Observações morfológicas no camarão-fantasma Callichirus seilacheri (Bott, 1955) (Decapoda, Callianassidae)
Authors: HERNÁEZ Patricio , GRANDA-RODRÍGUEZ Hernán , RIO Juliana Priscila Piva , PINHEIRO Marcelo Antonio Amaro
Published: March 2018

Callichirus seilacheri (Bott, 1955) é considerado um dos camarões-fantasmas mais comuns em zonas intertidais de praias arenosas, ao longo do Pací­­fico oriental tropical. O presente estudo fornece novas observações sobre a morfologia de C. seilacheri, com base numa revisão de material abundante coletado ao longo da costa do Pací­­fico, na América Central, incluindo espécimes da localidade tipo desta espécie (Playa Los Blancos, El Salvador). As caracterí­­sticas inéditas de C. seilacheri, incluem: carapaça com pequeno rostro triangular, e sem cerdas na extremidade; Pereiópodos 1 muito desiguais em machos adultos, mas não nas fêmeas e juvenis, de ambos os sexos; Primeiro pleópodo sexualmente dimórfico; Fêmeas com gonóporos ovais, cada um na porção ventral da coxa do terceiro par de pereiópodos, e poros genitais extras na porção ventral da coxa do quinto pereiópodo, estes últimos não funcionais (não conectados aos ovários). Aparentemente, a presença de gonóporos extras em fêmeas de C. seilacheri é um caráter vestigial, compartilhado com outros representantes do mesmo gênero.
Ocorrência de espécies de peixes não nativos em um rio Neotropical sob a influência da atividade aquí­­cola
Authors: RIBEIRO Vinícius Ricardo , GUBIANI Éder André , CUNICO Almir Manoel
Published: March 2018

A introdução de espécies não nativas é uma das grandes mudanças globais e uma das principais ameaças a ictiofauna continental. Dessa forma, esse trabalho teve por objetivo avaliar a composição e estrutura da ictiofauna do rio Azul, um tributário da margem esquerda da bacia do rio Piquiri, a fim de determinar a ocorrência, abundí­¢ncia e distribuição de espécies de peixes não nativas. Para isso, quatro amostragens foram realizadas de fevereiro a novembro de 2014 em três locais ao longo do rio, por meio do uso de equipamento de pesca elétrica. Durante o perí­­odo amostral, 32 espécies de peixes foram registradas, as quais pertenceram a 20 gêneros, 11 famí­­lias e cinco ordens. Houve o registro de oito espécies de peixes não nativas, dentre elas Gymnotus inaequilabiatus e Oreochromis niloticus estiveram presentes entre as cinco mais abundantes no rio Azul. Desse modo, a ictiofauna do rio Azul seguiu o padrão de distribuição esperado para a região Neotropical, com predominí­¢ncia de Characiformes e Siluriformes. Por outro lado, o aumento de ocorrência de espécies de peixes não nativas, observado da cabeceira para a foz do rio, indica possí­­vel processo de homogeneização biótica, potencialmente intensificado pelo escape de peixes não nativos advindos de pisciculturas.
Coke Oven Flue Temperature Control Based on Improved Implicit Generalized Predictive Control
Authors: Tian Zhongda ,   College of Information Science and Engineering, Shenyang University of Technology Shenyang, Liaoning 110870, China, Li Shujiang , Wang Yanhong
Published: March 2018

The flue temperature of coke oven is an important factor that guarantees the coke yield, the coke quality and the energy consumption of coking production. The heating process of coke oven is an object with multi control variables, nonlinear and large lag. The traditional PID control algorithm cannot further improve the control performance of the coke oven system. An improved implicit generalized predictive control algorithm with better control performance is proposed in this paper. Through inputting control increment value constrained by soft coefficient matrix, the calculation of matrix inversion is avoided. Soft coefficient matrix can reduce the computation time and ensure the rapidity of the system. At the same time, the input weight control law with smoothing filter is used to suppress the overshoot of the system output. Simulation results show that the proposed control method in this paper has the good control performance with faster computation speed. The proposed control method solves the problem of time variation and disturbance of coke oven system. The control algorithm of the coke oven flue temperature in this paper is effective.
Solving Order/Degree Problems by Using EDA-GK with a Novel Sampling Method
Authors: Hasegawa Ryoichi ,   Kindai University 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan, Handa Hisashi
Published: March 2018

The Estimation of Distribution Algorithms with Graph Kernels called EDA-GK is an extension of the Estimation of Distribution Algorithms that can work with graph-related problems. Individuals of the EDA-GK are represented by graphs. In this paper, the EDA-GK is applied to solve for the Order/Degree problems, which are an NP-hard problems and are a benchmark problem in graph theory studies. Moreover, we incorporate a new sampling method for generating offspring. Experimental results on several problem instances of Order/Degree problems show the effectiveness of the EDA-GK.
Effect of Postoperative Mechanical Axis Alignment on Survival and Functional Outcomes of Modern Total Knee Arthroplasties with Cement
Authors: Abdel Matthew P. , Ollivier Matthieu , Parratte Sebastien , Trousdale Robert T. , Berry Daniel J. , Pagnano Mark W.
Published: March 2018

We previously compared the 15-year survivorship of total knee arthroplasty (TKA) implants that were mechanically aligned (0° ± 3° relative to the mechanical axis) compared with those that were outside that range and considered outliers. The original publication included 398 TKAs (292 in the aligned group and 106 in the outlier group) performed from 1985 to 1990. At the time of follow-up in the previous study, 138 patients (155 TKAs) had died and 59 knees had been revised. Since that publication, 49 additional patients (87 knees) have died. At 20 years, 57 (19.5%) of the 292 knees in the mechanically aligned group had been revised compared with 16 (15.1%) of the 106 knees in the outlier group (p = 0.97). Postoperative alignment within 0° ± 3° of the mechanical axis did not provide a functional advantage at 1, 5, 10, 15, and/or 20 years postoperatively as demonstrated by the Knee Society scores being similar between the groups (p ≥ 0.2 at all intervals). At 20 years, we once again did not find that neutral mechanical alignment provided better implant survivorship than that found in the outlier group.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.