bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of High-Friction Surface Texture with Respect to Friction and Wear
Authors: Pranav Cibi , Do Minh-Tan , Tsai Yi-Chang
Published: June 2021

High Friction Surfaces (HFS) are applied to increase friction capacity on critical roadway sections, such as horizontal curves. HFS friction deterioration on these sections is a safety concern. This study deals with characterization of the aggregate loss, one of the main failure mechanisms of HFS, using texture parameters to study its relationship with friction. Tests are conducted on selected HFS spots with different aggregate loss severity levels at the National Center for Asphalt Technology (NCAT) Test Track. Friction tests are performed using a Dynamic Friction Tester (DFT). The surface texture is measured by means of a high-resolution 3D pavement scanning system (0.025 mm vertical resolution). Texture data are processed and analyzed by means of the MountainsMap software. The correlations between the DFT friction coefficient and the texture parameters confirm the impact of change in aggregates’ characteristics (including height, shape, and material volume) on friction. A novel approach to detect the HFS friction coefficient transition based on aggregate loss, inspired by previous works on the tribology of coatings, is proposed. Using the proposed approach, preliminary outcomes show it is possible to observe the rapid friction coefficient transition, similar to observations at NCAT. Perspectives for future research are presented and discussed.
Characterization and Parametric Optimization of Performance Parameters of DLC-Coated Tungsten Carbide (WC) Tool Using TOPSIS
Authors: Rana Ramakant , Walia R. S. , Murtaza Qasim
Published: June 2021

In this work, we have deposited the diamond-like carbon (DLC) coating on the tungsten carbide (WC) tool insert using the thermal chemical vapor deposition (CVD) method. For the growth of DLC coating, sugarcane bagasse was used as a carbon precursor. Raman spectroscopy, a field emission scanning electron microscope (FESEM), and X-ray diffraction (XRD) were used to confirm the presence of DLC coating on the tungsten carbide tool inserts. The hardness tests were also performed for inspecting the microhardness induced by the self-developed DLC coating on the tungsten carbide (WC) tool insert. To determine the optimum process parameters for the turning operation on an aluminum (6061) workpiece using a self-developed DLC-coated tungsten carbide (WC) tool insert, we have applied the technique for order preference by similarity to ideal solution (TOPSIS) methods. The process parameters considered for the optimization were feed rate, cutting speed, and depth of cut. Whereas chosen response variables were flank wear, temperature in the cutting zone, and surface roughness. TOPSIS is utilized to analyze the effects of selected input parameters on the selected output parameters. This study in this paper revealed that it was advantageous to develop the DLC coating on the tungsten carbide tool inserts for the machining applications. The results also revealed that a 0.635 mm depth of cut, feed rate of 0.2 mm/rev, and cutting speed of 480 m/min were the optimum combination of process parameters.
COPD Guidelines in the Asia-Pacific Regions: Similarities and Differences
Authors: Cheng Shih-Lung , Lin Ching-Hsiung
Published: June 2021

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease that is associated with significant morbidity and mortality, giving rise to an enormous social and economic burden. The Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (GOLD) report is one of the most frequently used documents for managing COPD patients worldwide. A survey was conducted across country-level members of Asia-Pacific Society of Respiratory (APSR) for collecting an updated version of local COPD guidelines, which were implemented in each country. This is the first report to summarize the similarities and differences among the COPD guidelines across the Asia-Pacific region. The degree of airflow limitation, assessment of COPD severity, management, and pharmacologic therapy of stable COPD will be reviewed in this report.
A Comparison of Full Arch Trueness and Precision of Nine Intra-Oral Digital Scanners and Four Lab Digital Scanners
Authors: Nulty Adam B.
Published: June 2021

(1) Background: The purpose of this study is to evaluate the full arch scan accuracy (precision and trueness) of nine digital intra-oral scanners and four lab scanners. Previous studies have compared the accuracy of some intra-oral scanners, but as this is a field of quickly developing technologies, a more up-to-date study was needed to assess the capabilities of currently available models. (2) Methods: The present in vitro study compared nine different intra-oral scanners (Omnicam 4.6; Omnicam 5.1; Primescan; CS 3600; Trios 3; Trios 4; Runyes; i500; and DL206) as well as four lab light scanners (Einscan SE; 300e; E2; and Ineos X5) to investigate the accuracy of each scanner by examining the overall trueness and precision. Ten aligned and cut scans from each of the intra-oral and lab scanners in the in vitro study were brought into CloudCompare. A comparison was made with the master STL using the CloudCompare 3D analysis best-fit algorithm. The results were recorded along with individual standard deviation and a colorimetric map of the deviation across the surface of the STL mesh; a comparison was made to the master STL, quantified at specific points. (3) Results: In the present study, the Primescan had the best overall trueness (17.3 ± 4.9), followed by (in order of increasing deviation) the Trios 4 (20.8 ± 6.2), i500 (25.2 ± 7.3), CS3600 (26.9 ± 15.9), Trios 3 (27.7 ± 6.8), Runyes (47.2 ± 5.4), Omnicam 5.1 (55.1 ± 9.5), Omnicam 4.6 (57.5 ± 3.2), and Launca DL206 (58.5 ± 22.0). Regarding the lab light scanners, the Ineos X5 had the best overall trueness with (0.0 ± 1.9), followed by (in order of increasing deviation) the 3Shape E2 (3.6 ± 2.2), Up3D 300E (12.8 ± 2.7), and Einscan SE (14.9 ± 9.5). (4) Conclusions: This study confirms that all current generations of intra-oral digital scanners can capture a reliable, reproducible full arch scan in dentate patients. Out of the intra-oral scanners tested, no scanner produced results significantly similar in trueness to the Ineos X5. However, the Primescan was the only one to be statistically of a similar level of trueness to the 3Shape E2 lab scanner. All scanners in the study had mean trueness of under 60-micron deviation. While this study can compare the scanning accuracy of this sample in a dentate arch, the scanning of a fully edentulous arch is more challenging. The accuracy of these scanners in edentulous cases should be examined in further studies.
Fault Diagnosis of a Wind Turbine Gearbox Based on Improved Variational Mode Algorithm and Information Entropy
Authors: Zhang Fan , Sun Wenlei , Wang Hongwei , Xu Tiantian
Published: June 2021

The working environment of wind turbine gearboxes is complex, complicating the effective monitoring of their running state. In this paper, a new gearbox fault diagnosis method based on improved variational mode decomposition (IVMD), combined with time-shift multi-scale sample entropy (TSMSE) and a sparrow search algorithm-based support vector machine (SSA-SVM), is proposed. Firstly, a novel algorithm, IVMD, is presented for solving the problem where VMD parameters (K and α) need to be selected in advance, which mainly contains two steps: the maximum kurtosis index is employed to preliminarily determine a series of local optimal decomposition parameters (K and α), then from the local parameters, the global optimum parameters are selected based on the minimum energy loss coefficient (ELC). After decomposition by IVMD, the raw signal is divided into K intrinsic mode functions (IMFs), the optimal IMF(s) with abundant fault information is (are) chosen based on the minimum envelopment entropy criterion. Secondly, the time-shift technique is introduced to information entropy, the time-shift multi-scale sample entropy algorithm is applied for the analysis of the complexity of the chosen optimal IMF and extract fault feature vectors. Finally, the sparrow search algorithm, which takes the classification error rate of SVM as the fitness function, is used to adaptively optimize the SVM parameters. Next, the extracted TSMSEs are input into the SSA-SVM model as the feature vector to identify the gear signal types under different conditions. The simulation and experimental results confirm that the proposed method is feasible and superior in gearbox fault diagnosis when compared with other methods.
Selection of Indigenous Saccharomyces cerevisiae Strains and Exploitation of a Pilot-Plant to Produce Fresh Yeast Starter Cultures in a Winery
Authors: Guerrini Simona , Barbato Damiano , Guerrini Lorenzo , Mari Eleonora , Buscioni Giacomo , Mangani Silvia , Romboli Yuri , Galli Viola , Parenti Alessandro , Granchi Lisa
Published: June 2021

The inoculation of grape juice with Saccharomyces cerevisiae strains selected from indigenous yeast populations can be a suitable tool to control alcoholic fermentation, contributing to producing wines with typical flavor and aroma and, hence, the demand for native starter cultures is increasing. However, since low amounts of indigenous yeast biomasses are usually required for local winemaking, the industrial production of these yeasts can be expensive. Therefore, in this study, after selecting an indigenous S. cerevisiae strain based on relevant oenological and technological features, a pilot-plant for easy and rapid production of fresh yeast biomass directly in a winery located in Tuscany, was exploited. The selected yeast strain was used as a starter to carry out 25 and 100 hL fermentations and its enological performance was compared with that of the commercial starter normally used in the winery. Chemical and sensory analysis of the resulting wines showed that they differentiated according to the used yeast strain, with the wines produced by the indigenous S. cerevisiae strain being characterized by a distinctive aromatic and sensory profile. In conclusion, the pilot-plant effectively resulted in producing fresh yeast starter cultures in the winery to be successfully used to carry out alcoholic fermentations.
Air Quality Impacts during the 2015 Rough Fire in Areas Surrounding the Sierra Nevada, California
Authors: Cisneros Ricardo , Schweizer Donald , Gharibi Hamed , Tavallali Pooya , Veloz David , Navarro Kathleen
Published: June 2021

The Rough Fire started on 31 July 2015 from a lightning strike, spread to over 61,000 ha and burned parts of the Sierra and Sequoia National Forests and the Sequoia & Kings Canyon National Parks, in California. Health advisories for smoke were issued in rural areas around the fire and in urban areas of the Central Valley. PM2.5 concentrations in rural and urban areas were used to assess the air quality impacts from the fire. Before the Rough Fire, 24-h PM2.5 concentrations for all sites ranged from 1 µg m−3o 50 µgm−3. During the wildfire, the 24-h PM2.5 concentrations ranged from 2 µgm−3 to 545 µgm−3, reaching hazardous levels of the federal Air Quality Index (AQI). The results indicate that the largest PM2.5 smoke impacts occurred at locations closer to and downwind of the fire in mountain communities of the Sierra Nevada, while the smoke impacts were lower in the urban areas.
Use of Wild Edible Plants: Can They Meet the Dietary and Nutritional Needs of Indigenous Communities in Central India
Authors: Mishra Alka , Swamy Singam Laxmana , Thakur Tarun Kumar , Bhat Rajeev , Bijalwan Arvind , Kumar Amit
Published: June 2021

Despite significant evidence base on quantifying ecosystem services, the role of biodiversity in supporting such services in diversified landscapes, and how indigenous communities exploit, utilize and manage plant resources in a biocultural regime, remains understudied. This study examines the role of wild edible plants (WEPs) in meeting the food, nutrition and household income of indigenous communities under the biodiversity rich landscape of the Achanakmaar-Amarkantak Biosphere Reserve (AABR—22°15′ to 22°58′ N latitudes and 81°25′ to 82°5′ East longitudes) of Central India. Results revealed remarkable differences among Baiga, Gond, Kol, and Oraon ethnic communities and also location (core, buffer and transition) effect on utilization pattern of wild edibles. A sum total of 172 WEPs comprising 60 vegetables, 70 fruits, seeds and nuts, 23 underground tubers and 19 mushrooms were collected, consumed, and surplus were marketed by the communities. On average, the number of wild edibles collected annually by households were in the following quantities: 40–240 kg leafy vegetables, 125–386 kg flowers, 120–250 kg fruits, 12–125 kg legumes, 24–120 kg tubers, 5–35 kg mushrooms. Among ethnic groups, the Baiga primitive community utilized 70–90% followed by Gonds (58–81%), Kols (52–78%), Oraons (43–79%), and other communities (38–68%) in different zones. WEPs have contributed to 5–24% (Rs 3559- 12,710) of household income, which was highest in the core zone and lowest in the transition zone. It was observed that WEPs were complemented the diets rather than being a substitute for staple foods. They supplied only 3.7–8.3% of energy and 1.1–4.9% protein requirements; however, they significantly supplemented ascorbic acid, thiamine, calcium, and iron by 38.1–73%, 13.7–35.4%, 17.2–29.1%, 2.6–13.5%, respectively. Significantly higher quantities of nutrients were supplemented in the core zone compared to other zones. WEPs were currently underutilized (less intake) especially in buffer and transition zones, complementing the staple foods and partially supplementing the essential macro- and micro-nutrients. However, these have the potential to fulfill the dietary needs and ensure balanced nutrition, if consumed in recommended portions and sizes. The paper discusses policy implications that ensure coherence and coordination of local indigenous communities for conservation and sustainable utilization of WEPs of AABR, Central India.
Influence of Lactobacillus paracasei HII01 Supplementation on Glycemia and Inflammatory Biomarkers in Type 2 Diabetes: A Randomized Clinical Trial
Authors: Toejing Parichart , Khampithum Nanticha , Sirilun Sasithorn , Chaiyasut Chaiyavat , Lailerd Narissara
Published: June 2021

It has been shown that gut dysbiosis can be associated with the development of type 2 diabetes mellitus (T2DM). Consequently, intervention with probiotics may be a useful approach to improve metabolic variables in diabetes. The present study aimed to evaluate the efficacy of L. paracasei HII01 on glycemia in T2DM patients. In a randomized, double-blind, placebo-controlled study, 50 participants were allocated to receive L. paracasei HII01 (50 × 109 CFU/day) or a placebo (corn starch 10 mg/day). Blood and fecal samples were assessed at baseline and at the end of the trial. After 12 weeks of intervention, fasting blood glucose level had significantly decreased in the probiotic group compared with the placebo group. Importantly, probiotic supplementation significantly decreased the plasma levels of LPS, TNF-α, IL-6 and hsCRP compared the placebo group. Additionally, an increase in beneficial bacteria and a decrease in pathogenic bacteria, which related to the improvement of SCFAs, was found following L. paracasei HII01 supplementation. These findings demonstrated that L. paracasei HII01 improved hyperglycemia and inflammatory markers by favorably modifying gut microbiota and subsequently ameliorating the leaky gut and endotoxemia, thereby suggesting a potential role as an adjuvant treatment in type 2 diabetes.
Yogurt Enriched with Isochrysis galbana: An Innovative Functional Food
Authors: Matos Joana , Afonso Cláudia , Cardoso Carlos , Serralheiro Maria L. , Bandarra Narcisa M.
Published: June 2021

Microalgae are a valuable and innovative emerging source of natural nutrients and bioactive compounds that can be used as functional ingredients in order to increase the nutritional value of foods to improve human health and to prevent disease. The marine microalga Isochrysis galbana has great potential for the food industry as a functional ingredient, given its richness in ω3 long chain-polyunsaturated fatty acids (LC-PUFAs), with high contents of oleic, linoleic, alpha-linolenic acid (ALA), stearidonic, and docosahexaenoic (DHA) acids. This study focuses on the formulation of a functional food by the incorporation of 2% (w/w) of I. galbana freeze-dried biomass and 2% (w/w) of I. galbana ethyl acetate lipidic extract in solid natural yogurts preparation. In the functional yogurt enriched with microalgal biomass, the ω3 LC-PUFA’s content increased (to 60 mg/100 g w/w), specifically the DHA content (9.6 mg/100 g ww), and the ω3/ω6 ratio (augmented to 0.8). The in vitro digestion study showed a poor bioaccessibility of essential ω3 LC-PUFAs, wherein linoleic acid (18:2 ω6) presented a bioaccessibility inferior to 10% and no DHA or eicosapentaenoic acid (EPA) was detected in the bioaccessible fraction of the functional yogurts, thus indicating a low accessibility of lipids during digestion. Notwithstanding, when compared to the original yogurt, an added value novel functional yogurt with DHA and a higher ω3 LC-PUFAs content was obtained. The functional yogurt enriched with I. galbana can be considered important from a nutritional point of view and a suitable source of essential FAs in the human diet. However, this needs further confirmation, entailing additional investigation into bioavailability through in vivo assays.
Color and Marbling as Predictors of Meat Quality Perception of Argentinian Consumers
Authors: Testa María Laura , Grigioni Gabriela , Panea Begoña , Pavan Enrique
Published: June 2021

In Argentina, color and intramuscular fat are the main attributes of raw beef quality; however, it is necessary to clarify how consumers use them, in order to establish different marketing strategies. Consumer preferences are affected by multiple factors. Thus, the objective of the present study was to identify the Argentinian consumer’s choice behavior regarding beef color and fat content. An online survey was carried out in Argentina. It inquired about socio-demographic characteristics, purchase and consumption habits and beliefs, showing pictures related to color, marbling and the amount of fat. Choice behavior was evaluated by asking why consumers chose a particular picture out of the ones shown. Several Kruskal–Wallis tests evaluated the different hypotheses. Three different decision trees using the CHAID analysis method were created. Multifactorial analysis was carried out for clustering consumers. Regarding consumer beliefs, 90% of the respondents agreed with the sentence, “The two main characteristics defining beef quality at purchase time are meat color and marbling”. Socio-demographic characteristics affected purchase habits and beliefs; they also affected perceptions about meat color and marbling. It was possible to build three consumer groups for future marketing strategies: “hedonic” focused on a pleasing sensory experience, “appearance” prioritized the visual aspects, and the “health-conscious” consumers were interested in their healthy nutrition.
Basil Seeds as a Novel Food, Source of Nutrients and Functional Ingredients with Beneficial Properties: A Review
Authors: Calderón Bravo Héctor , Vera Céspedes Natalia , Zura-Bravo Liliana , Muñoz Loreto A.
Published: June 2021

Basil (Ocimum basilicum L.) is found worldwide and is used in the food, pharmaceutical, and cosmetic industries; however, the nutritional and functional properties of the seeds are scarcely known. Basil seeds contain high concentrations of proteins (11.4–22.5 g/100 g), with all the essential amino acids except S-containing types and tryptophan; dietary fiber (soluble and insoluble) ranging from 7.11 to 26.2 g/100 g lipids, with linoleic (12–85.6 g/100 g) and linolenic fatty acids (0.3–75 g/100 g) comprising the highest proportions; minerals, such as calcium, potassium, and magnesium, in high amounts; and phenolic compounds, such as orientine, vicentine, and rosmarinic acid. In addition, their consumption is associated with several health benefits, such as the prevention of type-2 diabetes, cardio-protection, antioxidant and antimicrobial effects, and anti-inflammatory, antiulcer, anticoagulant, and anti-depressant properties, among others. The focus of this systematic review was to study the current state of knowledge and explore the enormous potential of basil seeds as a functional food and source of functional ingredients to be incorporated into foods.
Short-Term Electricity Price Forecasting by Employing Ensemble Empirical Mode Decomposition and Extreme Learning Machine
Authors: Khan Sajjad , Aslam Shahzad , Mustafa Iqra , Aslam Sheraz
Published: June 2021

Day-ahead electricity price forecasting plays a critical role in balancing energy consumption and generation, optimizing the decisions of electricity market participants, formulating energy trading strategies, and dispatching independent system operators. Despite the fact that much research on price forecasting has been published in recent years, it remains a difficult task because of the challenging nature of electricity prices that includes seasonality, sharp fluctuations in price, and high volatility. This study presents a three-stage short-term electricity price forecasting model by employing ensemble empirical mode decomposition (EEMD) and extreme learning machine (ELM). In the proposed model, the EEMD is employed to decompose the actual price signals to overcome the non-linear and non-stationary components in the electricity price data. Then, a day-ahead forecasting is performed using the ELM model. We conduct several experiments on real-time data obtained from three different states of the electricity market in Australia, i.e., Queensland, New South Wales, and Victoria. We also implement various deep learning approaches as benchmark methods, i.e., recurrent neural network, multi-layer perception, support vector machine, and ELM. In order to affirm the performance of our proposed and benchmark approaches, this study performs several performance evaluation metric, including the Diebold–Mariano (DM) test. The results from the experiments show the productiveness of our developed model (in terms of higher accuracy) over its counterparts.
A Study on the Knowledge, Attitudes, and Behaviors of Pregnant Women Regarding HIV and Routine Rapid Testing: An Assessment in a High-Risk Marginal Area
Authors: Jahangiry Leila , Aliyari Zahra , Ponnet Koen
Published: June 2021

Acquired immunodeficiency syndrome (AIDS) is one of the main obstacles to communities’ development. The disease mostly involves active and productive population groups. This study aimed to determine the knowledge, attitudes, and behaviors of pregnant women regarding HIV prevention and rapid HIV tests. Pregnant women who were referred to the local health centers and who were willing to participate in the study were interviewed. To collect data, a standard questionnaire was used among 200 pregnant women in eight local health centers of Kermanshah, Iran. The survey contained 50 questions on demographic characteristics and the knowledge, attitudes, and behaviors regarding HIV/AIDS prevention and rapid tests for pregnant women. Although the majority (82.5%) of the pregnant women knew that mother-to-child HIV transmission during pregnancy was possible, fewer than half (48.2%) of them knew that HIV can be transmitted from mother to child through breastfeeding. Only 22.5% of pregnant women knew that a Cesarean section for HIV-positive mothers is recommended. The mean attitudes of pregnant women toward HIV prevention and HIV rapid testing were 4.5 (SD = 0.4) and 4 (SD = 0.3), respectively. Of the women, 11.5% had participated in an HIV rapid test counseling class, and 25.5% had participated in HIV education and counseling classes. The low knowledge of mothers regarding HIV transmission highlights the need for education and counseling classes and campaigns to improve knowledge and behaviors related to HIV prevention, especially during pregnancy for women in marginal regions.
How Do Location-Based Augmented Reality Games Improve Physical and Mental Health? Evaluating the Meanings and Values of Pokémon Go Users’ Experiences through the Means-End Chain Theory
Authors: Ku Gordon Chih-Ming , Shang I-Wei , Li Meng-Fan
Published: June 2021

New technology has dramatically changed online games and blurred the boundary between active and passive activities. This study aims to explore the meanings and values of augmented reality online games by examining users’ Pokémon Go experiences through the means-end chain theory. Using data from interviews with 34 Pokémon Go users, this study adopts the soft laddering method to identify Pokémon Go’s potential attributes, consequences, and values, and to construct a hierarchical value map. The results indicated that Pokémon Go users pursue social relationships through play, and these relationships are triggered by the benefits of making new friends, maintaining current relationships with friends and family, and the attributes of prevalence, childhood memory, game design, and augmented reality. Subsequently, this study describes how Pokémon Go can be considered an active leisure activity because of its social, mental, and physical benefits and assesses the implications of its findings.
The Natural History of T Cell Metabolism
Authors: Braun Michel Y.
Published: June 2021

The cells of the immune system, particularly the T lymphocytes, have two main features that distinguish them from the cells of other tissues. They proliferate after activation and have the ability to move in tissues and organs. These characteristics compel them to develop metabolic plasticity in order to fulfil their immune function. This review focuses on the different known mechanisms that allow T cells to adapt their metabolism to the real-life circumstances they operate in, whether it is to exit quiescence, to differentiate into effector cells, or to participate in immune memory formation. Some of the metabolic adaptations to environmental variations that T cells are likely to undergo in their immune monitoring function are also discussed.
Environment and Diet Influence the Bacterial Microbiome of Ambigolimax valentianus, an Invasive Slug in California
Authors: Jackson Denise , Maltz Mia R. , Freund Hannah L. , Borneman James , Aronson Emma
Published: June 2021

Ambigolimax valentianus is an invasive European terrestrial gastropod distributed throughout California. It is a serious pest of gardens, plant nurseries, and greenhouses. We evaluated the bacterial microbiome of whole slugs to capture a more detailed picture of bacterial diversity and composition in this host. We concentrated on the influences of diet and environment on the Ambigolimax valentianus core bacterial microbiome as a starting point for obtaining valuable information to aid in future slug microbiome studies. Ambigolimax valentianus were collected from two environments (gardens or reared from eggs in a laboratory). DNA from whole slugs were extracted and next-generation 16S rRNA gene sequencing was performed. Slug microbiomes differed between environmental sources (garden- vs. lab-reared) and were influenced by a sterile diet. Lab-reared slugs fed an unsterile diet harbored greater bacterial species than garden-reared slugs. A small core microbiome was present that was shared across all slug treatments. This is consistent with our hypothesis that a core microbiome is present and will not change due to these treatments. Findings from this study will help elucidate the impacts of slug-assisted bacterial dispersal on soils and plants, while providing valuable information about the slug microbiome for potential integrated pest research applications.
A Comprehensive Survey on Data Utility and Privacy: Taking Indian Healthcare System as a Potential Case Study
Authors: Churi Prathamesh , Pawar Ambika , Moreno-Guerrero Antonio-José
Published: June 2021

Background: According to the renowned and Oscar award-winning American actor and film director Marlon Brando, “privacy is not something that I am merely entitled to, it is an absolute prerequisite.” Privacy threats and data breaches occur daily, and countries are mitigating the consequences caused by privacy and data breaches. The Indian healthcare industry is one of the largest and rapidly developing industry. Overall, healthcare management is changing from disease-centric into patient-centric systems. Healthcare data analysis also plays a crucial role in healthcare management, and the privacy of patient records must receive equal attention. Purpose: This paper mainly presents the utility and privacy factors of the Indian healthcare data and discusses the utility aspect and privacy problems concerning Indian healthcare systems. It defines policies that reform Indian healthcare systems. The case study of the NITI Aayog report is presented to explain how reformation occurs in Indian healthcare systems. Findings: It is found that there have been numerous research studies conducted on Indian healthcare data across all dimensions; however, privacy problems in healthcare, specifically in India, are caused by prevalent complacency, culture, politics, budget limitations, large population, and existing infrastructures. This paper reviews the Indian healthcare system and the applications that drive it. Additionally, the paper also maps that how privacy issues are happening in every healthcare sector in India. Originality/Value: To understand these factors and gain insights, understanding Indian healthcare systems first is crucial. To the best of our knowledge, we found no recent papers that thoroughly reviewed the Indian healthcare system and its privacy issues. The paper is original in terms of its overview of the healthcare system and privacy issues. Social Implications: Privacy has been the most ignored part of the Indian healthcare system. With India being a country with a population of 130 billion, much healthcare data are generated every day. The chances of data breaches and other privacy violations on such sensitive data cannot be avoided as they cause severe concerns for individuals. This paper segregates the healthcare system’s advances and lists the privacy that needs to be addressed first.
Understanding COVID-19 Epidemiology and Implications for Control: The Experience from a Greek Semi-Closed Community
Authors: Kotsiou Ourania S. , Papagiannis Dimitrios , Fradelos Evangelos C. , Perlepe Garyfallia , Miziou Angeliki , Siachpazidou Dimitra S. , Gourgoulianis Konstantinos I.
Published: June 2021

Background: We aimed to estimate the SARS-CoV-2 antigen and antibody seroprevalence in one of the worst-affected by the pandemic semi-closed communities in Greece, Deskati, and evaluate the sociodemographic and clinical correlations of functional antibody responses. Methods: The Ag2019n-CoV V1310/V1330 Rapid Test (Prognosis Biotech, Greece) was used for antigen detection. The Rapid Test 2019-nCoV Total Ig, V1210/V1230 (Prognosis Biotech, Greece), and the SARS-CoV-2 IgG II Quant method (Architect, Abbott, Illinois, USA) were used for antibody testing. Results: None of the participants had a positive antigen result. SARS-CoV-2 seropositivity ranged from 13% to 45% in the study population, depending on the method. One-third of the participants with known past infection had a positive antibody test result 77 ± 13 days after infection. Two-fifths of infections determined by serology were asymptomatic. The advancing age and hospitalization predicted seropositivity among patients with past infection. Half of the participants who tested positive for antibodies were not aware of past infection. Conclusions: High-burden contexts in Greece, such as Deskati, are not so far from herd immunity thresholds. We highlighted the value of low-cost serosurveys targeting both symptomatic and asymptomatic populations to evaluate the natural immune response to SARS-CoV-2 in nonvaccinated susceptibles and design evidence-based policies for lifting lockdowns.
Effect of Hepatocellular Carcinoma Surveillance Programmes on Overall Survival in a Mixed Cirrhotic UK Population: A Prospective, Longitudinal Cohort Study
Authors: Haq Mohammad Inamul , Drake Thomas M. , Goh Tee Lin , Ahmed Asma , Forrest Ewan , Barclay Stephen , Gillespie Ruth , Priest Mathew , Evans Jeff , Graham Janet , Ballantyne Stuart , McMillan Donald C. , Hayes Peter C. , Bird Thomas G. , Stanley Adrian J.
Published: June 2021

Introduction: Surveillance for hepatocellular carcinoma (HCC) is recommended by national and international guidelines. However, there are no trial data on whether surveillance improves clinical outcomes in a UK cirrhosis population of mixed aetiology. Our aim was to determine the impact of, and adherence to, surveillance on overall survival. Methods: We prospectively collected data on consecutive patients diagnosed with HCC between January 2009 and December 2015 at two large UK centres. We assessed outcomes depending on whether they had been entered into an HCC surveillance programme, and if they had adhered to that. Results: Out of 985 patients diagnosed with HCC in this study, 40.0% had been enrolled in a surveillance programme. Of these, 76.6% were adherent with surveillance and 24.4% were not. Adherence to surveillance was significantly associated with improved overall survival, even when accounting for lead-time bias using different approaches (HR for 270 days lead-time adjustment 0.64, 0.53 to 0.76, p < 0.001). Conclusions: When adjusted for lead-time bias, HCC surveillance is associated with improved overall survival; however, the beneficial effect of surveillance on survival was lower than reported in studies that did not account fully for lead-time bias.
Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine
Authors: Lee Sang-Hwa , Lee Yeonkyeong , Song Minji , Lee Jae Jun , Sohn Jong-Hee
Published: June 2021

Neuroimaging and neuropsychological investigations have indicated that migraineurs exhibit frontal lobe-related cognitive impairment. We investigated whether orbitofrontal and dorsolateral functioning differed between individuals with episodic migraine (EM) and chronic migraine (CM), focusing on orbitofrontal dysfunction because it is implicated in migraine chronification and medication overuse headache (MOH) in migraineurs. This cross-sectional study recruited women with CM with/without MOH (CM + MOH, CM − MOH), EM, and control participants who were matched in terms of age and education. We conducted neuropsychological assessments of frontal lobe function via the Trail Making Test (TMT) A and B, the Wisconsin Card Sorting Test (WCST), and the Iowa Gambling Task (IGT). We enrolled 36 CM (19 CM + MOH, 17 CM − MOH), 30 EM, and 30 control participants. The CM patients performed significantly (p < 0.01) worse on the TMT A and B than the EM patients and the control participants. The WCST also revealed significant differences, with poorer performance in the CM patients versus the EM patients and the control participants. However, the net scores on the IGT did not significantly differ among the three groups. Our findings suggest that the CM patients exhibited frontal lobe dysfunction, and, particularly, dorsolateral dysfunction. However, we found no differences in frontal lobe function according to the presence or absence of MOH.
Executive Dysfunctions in Schizophrenia: A Critical Review of Traditional, Ecological, and Virtual Reality Assessments
Authors: Tyburski Ernest , Mak Monika , Sokołowski Andrzej , Starkowska Anna , Karabanowicz Ewa , Kerestey Magdalena , Lebiecka Zofia , Preś Joanna , Sagan Leszek , Samochowiec Jerzy , Jansari Ashok S.
Published: June 2021

In recent years, interest has grown in measuring executive function in schizophrenia with ecological and virtual reality (VR) tools. However, there is a lack of critical analysis comparing those tools with traditional ones. This paper aims to characterize executive dysfunction in schizophrenia by comparing ecological and virtual reality assessments with traditional tools, and to describe the neurobiological and psychopathological correlates. The analysis revealed that ecological and VR tests have higher levels of verisimilitude and similar levels of veridicality compared to traditional tools. Both negative symptoms and disorganization correlate significantly with executive dysfunction as measured by traditional tools, but their relationships with measures based on ecological and VR methods are still unclear. Although there is much research on brain correlates of executive impairments in schizophrenia with traditional tools, it is uncertain if these results will be confirmed with the use of ecological and VR tools. In the diagnosis of executive dysfunction, it is important to use a variety of neuropsychological methods—especially those with confirmed ecological validity—to properly recognize the underlying characteristics of the observed deficits and to implement effective forms of therapy.
Investigation of the Phase Transitions and Magneto-Electric Response in the 0.9(PbFe0.5Nb0.5)O3-0.1Co0.6Zn0.4Fe1.7Mn0.3O4 Particulate Composite
Authors: Bhoi Krishnamayee , Dash Smaranika , Dugu Sita , Pradhan Dhiren K. , Singh Anil K. , Vishwakarma Prakash N. , Katiyar Ram S. , Pradhan Dillip K.
Published: June 2021

Multiferroic composites with enhanced magneto-electric coefficient are suitable candidates for various multifunctional devices. Here, we chose a particulate composite, which is the combination of multiferroic (PbFe0.5Nb0.5O3, PFN) as matrix and magnetostrictive (Co0.6Zn0.4Fe1.7Mn0.3O4, CZFMO) material as the dispersive phase. The X-ray diffraction analysis confirmed the formation of the composite having both perovskite PFN and magnetostrictive CZFMO phases. The scanning electron micrograph (SEM) showed dispersion of the CZFMO phase in the matrix of the PFN phase. The temperature-dependent magnetization curves suggested the transition arising due to PFN and CZFMO phase. The temperature-dependent dielectric study revealed a second-order ferroelectric to the paraelectric phase transition of the PFN phase in the composite with a small change in the transition temperature as compared to pure PFN. The magnetocapacitance (MC%) and magnetoimpedance (MI%) values (obtained from the magneto-dielectric study at room temperature (RT)) at 10 kHz were found to be 0.18% and 0.17% respectively. The intrinsic magneto-electric coupling value for this composite was calculated to be 0.14 mVcm−1Oe−1, which is comparable to other typical multiferroic composites in bulk form. The composite PFN-CZFMO exhibited a converse magneto-electric effect with a change in remanent magnetization value of −58.34% after electrical poling of the material. The obtained outcomes from the present study may be utilized in the understanding and development of new technologies of this composite for spintronics applications.
Performance Comparisons of Youth Weightlifters as a Function of Age Group and Sex
Authors: Mizuguchi Satoshi , Cunanan Aaron J. , Suarez Dylan G. , Cedar William E. , South Mark A. , Gahreman Daniel , Hornsby William G. , Stone Michael H.
Published: June 2021

This study was designed to provide an overview of weightlifting performance as a function of age group and sex and evaluate the potential of countermovement jump height (CMJH) as a tool to gauge performance potential. Data from 130 youth athletes (female, n = 65 & male, n = 65) were used to examine progression of performance (Total and Sinclair total) and the relationship between CMJH and Sinclair total while considering interactions between CMJH and age and/or sex. ANOVAs with post hoc analyses revealed that both totals had a statistical first-order polynomial interaction effect between age group and sex and the difference between age groups of 12–13 and 14–15 years old was statistically greater for male than female. A linear model, developed to examine the relationship, revealed that CMJH and CMJH x sex x age rejected the null hypothesis. Our primary findings are that male youth weightlifters have a higher rate of performance progression, possibly owing to puberty, and CMJH may be a better gauging tool for older male youth weightlifters.
Physics-Based Simulations of Chip Flow over Micro-Textured Cutting Tool in Orthogonal Cutting of Alloy Steel
Authors: Patel Kaushalendra V. , Jarosz Krzysztof , Özel Tuğrul
Published: June 2021

Physics-based process simulations have the potential to allow virtual process design and the development of digital twins for smart machining applications. This paper presents 3D cutting simulations using the finite element method (FEM) and investigates the physical state variables that are fundamental to the reduction in cutting forces, friction, and tool wear when micro-textured cutting tools are employed. For this goal, textured cemented carbide cutting tool inserts are designed, fabricated, and tested in the orthogonal dry cutting of a nickel-chromium-molybdenum alloy steel. Cutting forces and friction coefficients are compared against the non-textured tool, revealing the effects of texture parameters. Chip flow over the textured tool surface and process variables at the chip-tool contact are investigated and compared. The results reveal the fundamental sources of such improvements. Archard’s wear rate as a composition of process variables is utilized to compare experimental and simulated wear on the textured cutting tools. The effects of texture and cutting conditions on tool wear and adhesion characteristics are further discussed on the simulation results with experimental comparisons. It was found that the results obtained from these simulations provide further fundamental insights about the micro-textured cutting tools.
Energy Sources Generation and Energy Cascades along the Kuroshio East of Taiwan Island and the East China Sea
Authors: Wang Ru , Hou Yijun , Liu Ze
Published: June 2021

There are multi-spatial-scale ocean dynamic processes in the western boundary current region, so the budget of energy source and sink in the Kuroshio Current area can describe the oceanic energy cycle and transformation more accurately. The slope of the one-dimensional spectral energy density varies between −5/3 and −3 in the wavenumber range of 0.02–0.1 cpkm, indicating an inverse energy cascade in the Kuroshio of Taiwan Island and the East China Sea. According to the steady-state energy evolution, an energy source must be present. The locations of energy sources were identified using the spectral energy transfer calculated by 24 years of Ocean General Circulation Model for the Earth Simulator (OFES) data. At the sea surface, the kinetic energy (KE) sources are mainly within 23.2°–25.6° Nand 28°–29° N at less than 0.02 cpkm and within 23.2°–25° N and 26°–30° N at 0.02–0.1 cpkm. The available potential energy (APE) sources are mainly within 22°–28° N and 28.6°–30° N at less than 0.02 cpkm and within 22.6°–24.6° N, 25.4°–28° N and 29.2°–30° N at 0.02–0.1 cpkm. Beneath the sea surface, the energy sources are mainly above 400 m depth. Wind stress and density differences are primarily responsible for the KE and APE sources, respectively. Once an energy source is formed, to maintain a steady state, energy cascades (mainly inverse cascades by calculating spectral energy flux) will be engendered. By calculating the energy flux at 600 m depth, KE changes from inflow (sink) to outflow (source), and the conversion depth of source and sink is 380 m. However, outflow of the APE behaves as the source.
Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28null T Lymphocytes in Rheumatoid Arthritis Disease
Authors: Rioseras Beatriz , Moro-García Marco Antonio , García-Torre Alejandra , Bueno-García Eva , López-Martínez Rocio , Iglesias-Escudero Maria , Diaz-Peña Roberto , Castro-Santos Patricia , Arias-Guillén Miguel , Alonso-Arias Rebeca
Published: June 2021

Expanded CD4+CD28null T lymphocytes are found in the tissues and peripheral blood of patients with many autoimmune diseases, such as rheumatoid arthritis (RA). These highly differentiated cells present potent inflammatory activity and capability to induce tissue destruction, which has been suggested to predispose to the development of more aggressive disease. In fact, preferential migration to inflammatory sites has been proposed to be a contributing factor in the progression of autoimmune and cardiovascular diseases frequently found in these patients. The functional activity of CD4+CD28null T lymphocytes is largely dependent on interleukin 15 (IL-15), and this cytokine may also act as a selective attractor of these cells to local inflammatory infiltrates in damaged tissues. We have analysed, in RA patients, the migratory properties and transcriptional motility profile of CD4+CD28null T lymphocytes compared to their counterparts CD28+ T lymphocytes and the enhancing role of IL-15. Identification of the pathways involved in this process will allow us to design strategies directed to block effector functions that CD4+CD28null T lymphocytes have in the target tissue, which may represent therapeutic approaches in this immune disorder.
Changes in the Prevalence of Metabolic Syndrome, Its Components, and Relevant Preventive Medication between 2011 and 2018 in the Northeast Hungarian Roma Population
Authors: Piko Peter , Dioszegi Judit , Kosa Zsigmond , Sandor Janos , Moizs Mariann , Adany Roza
Published: June 2021

Metabolic syndrome (MetS) is a cluster of clinical conditions that poses a major health burden worldwide. In the present study, we investigate the changes in the prevalence of MetS and its components among the Roma in two disadvantaged counties in Northeastern Hungary focusing on a seven-year-long period. The database of the present study is based on cross-sectional surveys of the Hungarian Roma population (aged 20–64 years) conducted in 2011 (n = 458) and 2018 (n = 374). The increase in the prevalence of MetS itself in the whole Roma population was not found to be significant in the period examined (although it increased from 40.0% up to 46.0%, p = 0.080); however, regarding its components, there was a significant increase in the prevalence of central obesity (from 62.7% to 73.3%, p = 0.001) and raised blood pressure (BP) or treated hypertension (from 45.2% to 54.5%, p = 0.007). These changes were mainly observed in the younger age groups, so the risk for MetS increased significantly in the 20–34 (OR = 1.10, p = 0.038) and 35–49 (OR = 1.07, p = 0.048) year age groups in the 2018 study population compared the 2011 one. The increasing prevalence of hidden hypertension and, consequently, untreated individuals with raised BP (from 29.6% to 43.5%, p = 0.014) among females is quite alarming; therefore, a targeted public health strategy and targeted interventions are desperately needed to prevent further worsening of the current situation.