bluuebunny/crossref_metadata_2025 huggingface dataset:
A perceptual field test in object experts using gaze-contingent eye tracking
Authors: Hagen Simen , Vuong Quoc , Jung Liandra , Chin Michael D. , Scott Lisa S. , Tanaka Jim
Published: September 2022

A hallmark of expert object recognition is rapid and accurate subordinate-category recognition of visually homogenous objects. However, the perceptual strategies by which expert recognition is achieved is less known. The current study investigated whether visual expertise changes observers’ perceptual field (e.g., their ability to use information away from fixation for recognition) for objects in their domain of expertise, using a gaze-contingent eye-tracking paradigm. In the current study, bird experts and novices were presented with two bird images sequentially, and their task was to determine whether the two images were of the same species (e.g., two different song sparrows) or different species (e.g., song sparrow and chipping sparrow). The first study bird image was presented in full view. The second test bird image was presented fully visible (full-view), restricted to a circular window centered on gaze position (central-view), or restricted to image regions beyond a circular mask centered on gaze position (peripheral-view). While experts and novices did not differ in their eye-movement behavior, experts’ performance on the discrimination task for the fastest responses was less impaired than novices in the peripheral-view condition. Thus, the expert’s used peripheral information to a greater extent than novices, indicating that the experts have a wider perceptual field to support their speeded subordinate recognition.
Changes in Adolescents' Daily-Life Solitary Experiences During the COVID-19 Pandemic: An Experience Sampling Study
Authors: Bamps Eva , Achterhof Robin , Lafit Ginette , Teixeira Ana , Akcaoglu Zeynep , Hagemann Noëmi , Hermans Karlijn Susanna Francisca Maria , Hiekkaranta Anu Pauliina , Janssens Julie , Lecei Aleksandra , Myin-Germeys Inez , Kirtley Olivia J
Published: September 2022

Background: Adolescent solitude was drastically impacted by the COVID-19 pandemic. As solitude is crucial for adolescent development through its association with both positive and negative developmental outcomes, it is critical to understand how adolescents’ daily-life solitary experiences changed as a result of the pandemic.Methods: Using three waves of Experience Sampling Method data from a longitudinal study, we compared adolescents’ daily-life solitary experiences in the early (nT1=100; MAge=16.1; SDAge=1.9; 93% girls) and mid-pandemic (nT2=204; MAge=16.5; SDAge=2.0; 79% girls) to their pre-pandemic experiences.Results: We found that adolescents with lower levels of pre-pandemic social support and social skills reported wanting to be alone less and feeling like an outsider more at both time points during the pandemic. In the mid-pandemic wave, adolescents with higher levels of pre-pandemic social support and social skills reported decreases in positive affect compared to the pre-pandemic wave.Conclusion: This study shows that adolescents’ daily-life solitary experiences worsened throughout the COVID-19 pandemic. There should be continued concern for the wellbeing of all adolescents, not only those already at risk, as effects of the pandemic on mental health might only manifest later.
Hearing Water Temperature: Characterizing the Development of Nuanced Perception of Sound Sources
Authors: Agrawal Tanushree , Schachner Adena
Published: September 2022

Without conscious thought, listeners link events in the world to sounds they hear. We study one surprising example: Adults can judge the temperature of water simply from hearing it being poured. We test development of the ability to hear water temperature, with the goal of informing developmental theories regarding the origins and cognitive bases of nuanced sound source judgments. We first confirmed that adults accurately distinguished the sounds of hot and cold water (pre-registered Exps. 1, 2; total N=384), even though many were unaware or uncertain of this ability. By contrast, children showed protracted development of this skill over the course of middle childhood (Exps. 2, 3; total N=178). In spite of accurately identifying other sounds and hot/cold images, older children (7-11 years) but not younger children (3-6 years) reliably distinguished the sounds of hot and cold water. Accuracy increased with age; 11 year old’s performance was similar to adults’. Adults also showed individual differences in accuracy that were predicted by their amount of prior relevant experience (Exp. 1). Experience may similarly play a role in children’s performance; differences in auditory sensitivity and multimodal integration may also contribute to young children’s failures. The ability to hear water temperature develops slowly over childhood, such that nuanced auditory information that is easily and quickly accessible to adults is not available to guide young children’s behavior.
Funkcionalna prilagodba prirodnog pomlatka hrasta kitnjaka i obične bukve na različite stanišne prilike
Authors: Sever Krunoslav , Hodak Luka , Škvorc Željko , Franjić Jozo , Karažija Tomislav , Krstonošić Daniel , Katičić Bogdan Ida , Bogdan Saša , Vukmirović Antonia
Published: September 2022

Cilj ovoga rada bio je usporediti dvije mješovite sastojine (provenijencije) obične bukve i hrasta kitnjaka, iz istočne (provenijencija Slavonski Brod - SB) i sjeverozapadne (provenijencija Karlovac - KA) Hrvatske, s obzirom na klimatske i edafske prilike te raspraviti njihov utjecaj na rast i produkciju suhe tvari prirodnog pomlatka hrasta kitnjaka i obične bukve u kontekstu njegove funkcionalne prilagodbe na prethodno spomenute stanišne prilike. Glavna razlika između provenijencija s obzirom na klimatske prilike ogleda se u prosječno većoj količini oborina na području provenijencije KA. Unatoč tomu, zbog nepovoljnog rasporeda oborina za vrijeme rasta i razvoja istraživanog pomlatka u razdoblju 2016. – 2020. godine područje provenijencije KA odlikovalo se učestalijom pojavom sušnih perioda nego područje provenijencije SB. S obzirom na edafske prilike (fizikalne i kemijske značajke tla) provenijencije se nisu značajnije razlikovale. Međutim, tlo provenijencije KA odlikovalo se nešto lakšom strukturom (manje gline i više skeleta) u odnosu na tlo provenijencije SB. Razlike između provenijencija i vrsta s obzirom na cijeli niz mjerenih parametara koji opisuju rast i produkciju suhe tvari istraživanog pomlatka uključujući i njihove alometrijske odnose ispitan je pomoću dvofaktorske ANOVA-e. Dobiveni rezultati ukazuju da je pomladak iz provenijencije KA ulagao više suhe tvari u rast i razvoj korijenja s posebnim naglaskom na sitno korijenje i pri tom se dublje zakorjenjivao te razvijao deblju i nižu stabljiku nego pomladak iz provenijencije SB. To ukazuje da je pomladak iz provenjencije KA funkcionalno prilagođeniji sušem staništu. Takav rezultat mogao bi biti posljedica različito ispoljene fenotipske modifikacije (reakcije na sušu) i/ili stvarnih genetskih razlika između provenijencija, što ovom prilikom nije bilo moguće točnije razlučiti. Dobivene razlike u rastu i produkciji suhe tvari između kitnjakova i bukova pomlatka odgovaraju već otprije poznatom načinu njihove funkcionalne prilagodbe na vlažnost, odnosno suhoću staništa. To znači da se kitnjakov pomladak dublje zakorjenjivao i pri tom je više suhe tvari ulagao u rast krupnog korijenja u odnosu na bukov pomladak koji se pliće zakorjenjivao i pri tom više suhe tvari ulagao u rast sitnog korijenja.
Some Fixed Point Results on Multiplicative Metric Spaces
Authors: Ansar Ahmad , Muh. Akbar Idris
Published: September 2022

In this paper, we first discussed some results about multiplicative metric spaces to support the main results. The aim of this paper is to present fixed point some result that satisfied some generalized of contraction mapping related to multiplicative metric spaces. Furthermore, some examples are given to support results
Hubungan Kemampuan Numerik Dan Kemampuan Verbal Siswa dalam Pembelajaran Matematika
Authors: Quraisy Andi
Published: September 2022

This research was conducted with the aim of knowing the relationship or correlation between numerical abilities and verbal abilities of UPTD students at SMP Negeri 3 Sinjai. This study is a quantitative research with a research sample of 67 students. The sampling method used is Cluster Random Sampling. The data collection technique in this study used a numerical ability questionnaire and a verbal ability questionnaire. Data were analyzed by descriptive statistics and inferential statistics using correlation analysis. The results indicated that the average value of students' numerical ability was above the value of verbal ability, namely 68.05 for numerical ability and 55.68 for verbal ability, while based on the results of the calculation of correlation analysis techniques, the correlation coefficient value (r) was 0.33. The correlation of the two variables is in the weak category. These results suggest that there is a significant positive relationship between numerical ability and verbal ability. The higher the numerical ability, the higher the verbal ability. Conversely, the lower the numerical ability, the lower the verbal ability.
ENTREVISTA COM O VAMPIRO:
Authors: Costa Aline Pereira de Jesus , Fernandes Fernanda Surubi
Published: September 2022

O discurso é uma prática, constitui-se na relação com o outro, com a língua, a história e a ideologia, o que permite produzir uma multiplicidade de sentidos. O presente artigo tem como objetivo analisar como o corpo do monstro/vampiro se significa a partir de diferentes materialidades. Assim, este estudo analisa as obras literária e cinematográfica Entrevista com o vampiro de Anne Rice (1992) e Neil Jordan (1994), respectivamente. Desta forma, apresentamos uma breve introdução do horror na literatura de língua inglesa, seguido de algumas noções sobre a análise de discurso: sujeito e corpo, considerando o vampiro em obras cinematográficas e um olhar sobre a obra literária: corpo e morte em Entrevista com o vampiro, bem como a obra cinematográfica: corpo e desejo em Entrevista com o vampiro. Sendo assim, buscamos abordar questões como vampirismo e a ruptura dos padrões sociais impostas ao vampiro, por meio de diferentes materialidades.
PERAN KADER KAMPUNG KB PADA MASA PANDEMI COVID 19
Authors: Subekti Aditya Farit
Published: September 2022

Kampung KB is an integrated development program population, family planning, as well as related sector development in an effort to improve quality of life for families and communities. Kampung KB’s cadres, are volunteers who are chosen to help organize population and family planning programs. This study  knowing aims to role of kb village cadres in socializing preganancy distance arrangements during Pandemic. type of this research is descriptive This research is classified as using a qualitative research design. informants in this research amounted to 4 representative cadres of each RW chosen by Key Person. data collection in this research used a source triangulation technique with in-depth interviews and activity documentation. Results  research are characteristics  Kampung KB’s cadres in Tegaren Village are quite good, supported by self-motivation, as well support from local community and religious leaders, although in this case there are no binding rules to help performance of cadres. In addition, it is known that even during pandemic, cadres still continue to socialize and education community by door to door to help regulate distance between pregnancies in  community. conclusion in this research is cadres continue to carry out their duties to socialize pregnancy distance and use of contraceptives as well as health monitoring community by door to door. In research, it is recommended for cadres to further increase their resource potential.
PENGARUH SENAM LANSIA TERHADAP PENURUNAN TEKANAN DARAH PADA LANSIA PENDERITA HIPERTENSI DI DESA JOSARI KECAMATAN JETIS KABUPATEN PONOROGO
Authors: Nurhastuti Ria Fajar
Published: September 2022

Blood Pressure in elderly will change with age, in general after entering the age of 45 years the condition of the arterial wall will be thickened by several factors such as the accumulation of collagen substances in the muscle layer, so that it can cause blood vessels to narrow gradually. Elderly gymnastics is a mild and non-stressful exercise proven to help improve physical and mental health for the elderly. The purpose of this study was to determine the effect of elderly gymnastics on reducing blood pressure in the elderly who experience hypertension in Josari Village, Jetis District, Ponorogo Regency. The design used in this study was to use a "Quasi experimental pre-post test" with the intervention of elderly gymnastics. Univariate data analysis and bivariate analysis, and statistical Paired T test. With a safety level of α=0.05, which means Ha accepted Ho is rejected, it can be conclude that there is an effect of elderly gymnastics on blood pressure reduction in elderly with hypertension.
PENGARUH HEALTH EDUCATION TERHADAP PENGETAHUAN IBU TENTANG PIJAT BAYI DI PMB ERNA PENIWATI
Authors: Mustikawati Ambika Kurnia
Published: September 2022

Haemorrhoids are common in pregnant women in the second or third trimester of pregnancy. Increased intra-pressure due to fetal growth and changes in the hormone progesterone causes the hemorrhoidal veins to become wide. Pregnancy hemorrhoids are temporary hemorrhoids which means they will disappear some time after delivery, but can cause a very uncomfortable feeling, itching around the anus and even bleeding during bowel movements. Therefore, self care is needed, one of them is the sitz bath method. The design in this study is a pre-experiment with the One Group Pretest-Posttest design approach. The population in this study were all mothers with hemorrhoids who participated in the pregnant class at Balong Health Center for the period of 1-28 February 2020, a total of 37 people. The sampling method used accidental sampling of 31 people. Instrument with quesioner Statistical test using the Wilcoxon Signed-Rank Test through the SPSS program with α = 0.05. The result of knowledge of mothers about Sitz Bath Therapy in the Work Area of ​​Puskesmas Balong, Ponorogo Regency, before health education was carried out, most of them were 16 respondents (51.6%) had sufficient knowledge and after health education was carried out most of them 18 respondents (58.1%) had good knowledge. There is an effect of health education on maternal knowledge about Sitz Bath Therapy in the working area of ​​ Health Center Balong, Ponorogo with a p value of 0.000 ≤ α 0.05. The role of health workers as educators is better to carry out routine health education during the provision of care, especially regarding the method of sitz bath therapy so that targets can better understand and be able to overcome hemorrhoid problems that occur in pregnancy.
KAJIAN STRATEGIS PERCEPATAN DAN PENGEMBANGAN FITOFARMAKA UNTUK KESEHATAN MASYARAKAT
Authors: Saputra Hermawan , Faryanti Desrialita , Farhan Farhan
Published: September 2022

Indonesia is a "megabio-diversity" country, the World Conservation Monitoring Center has reported that the territory of Indonesia is an area where many types of medicinal plants are found with the number of plants that have been utilized reaching 2,518 species (EISAI, 1995). Indonesia's wealth of biological resources is a potential resource in the pharmaceutical sector which has not been fully utilized. (Prodisfar, 2021). The purpose of this study is to develop and recommend strategies for accelerating and developing phytopharmaceuticals for public health in Indonesia. The research method is Qualitative Method. The population and sample of the study were conducted by purposive sampling involving informants from across ministries, the pharmaceutical industry, as well as professional organizations in Indonesia, and hospitals. The results of the study show that Indonesia must carry out an acceleration strategy using an intensive strategy (Market Penetration and Product Development and Market Product), while the development strategy is carried out by backward integration, forward integration and horizontal integration as an effort to maintain public health in Indonesia. Suggestions for further researchers, in order to be able to conduct special studies on halal products and pharmacoeconomics for public health.
Chemical composition, physicochemical evaluation and sensory analysis of yogurt added with extract of polyphenolic compounds from Quercus crassifolia oak bark
Authors: Valencia-Avilés Eréndira , García-Pérez Martha Estrella , Garnica-Romo Ma. Guadalupe , Figueroa-Cárdenas Juan de Dios , Paciulli Maria , Martinez-Flores Hector Eduardo
Published: September 2022

Introduction: A diet high in calories and saturated fats has been associated with health problems that have been increasing worldwide. Therefore, it is required to increase the number of formulated foods that generate well-being to health. Yogurt is a widely consumed food by all sectors of the population and it can be used as a vehicle to incorporate bioactive compounds. The phenolic compounds present in forest residues, such as those from oak bark, can be used and incorporated into yogurt, to increase its benefits as a functional food.Objective: The objective of this study was to develop a multifunctional yogurt enriched with vegetable oil (2.3% w/w) as a source of omega 6 and 3 and adding nanocapsules (24.5% w/w) of an extract of oak bark from Quercus crassifolia, rich in in phenolic compounds and high antioxidant capacity.Methods: Three yogurt formulations were prepared: F1: yogurt was made with non-fat milk, used as a control, F2: yogurt was prepared with non-fat milk and added with vegetable palm oil, and F3: non-fat yogurt was added with vegetable oil and nanoencapsulated oak bark phenolic extract. The yogurts were characterized in their chemical composition, microbiological analysis, and sensory analysis. Results: The multifunctional product F3 and product F2 presented lactic acid bacteria in concentration of 3.01X106 and 4.73x106, respectively, preserving characteristics of probiotic food. Product F3 presented low levels of syneresis (7.34%) and it was significantly different from the control yogurt (9.01%). The viscosity increased from 150 cP in the control yogurt to 341 cP in F3, due to the increase in the concentrations of solids by nanoencapsulating the phenolic. The wall material used for nanoencapsulation was sodium caseinate and mantodextrin. However, this increase in viscosity did not affect the sensory evaluation of the product. There were no significant differences between the control yogurt and the F2 and F3 products.Conclusion: A yogurt added with vegetable oil and nanoencapsulated oak bark phenolic extract was obtained. It was enhanced by the presence of probiotics, bioactive compounds, and essential fatty acids, and then evaluated and accepted by a sensory panel. Nanoencapsulation is a viable alternative to mask the characteristic astringent taste of phenolic compounds because it was not detected by the panelists. Keywords: waste recovery; functional dairy foods; essential fatty acids; probiotics; antioxidants; sensory.
Leuit Bukan Sekadar Lumbung
Authors: Kusdiwanggo Susilo
Published: September 2022

Sosok leuit yang eksotis sering mengelabuhi dan menyilapkan mata orang yang melihatnya. Terlebih saat pandangan pertama. Terutama bagi mereka yang berkacamata tektonika semata. Semua dianggap sama, padahal sebenarnya berbeda. Terjebak dalam persepsi bentuk wadah fisik saja. Dalam anggunnya, leuit memendam sarat makna, khas kebudayaan Nusantara. Khazanah arsitektur yang tidak bisa dilihat hanya dari satu sudut saja. Diperlukan pengalaman kehadiran untuk membaca sosok leuit. Perpaduan waktu-pelaku-laku yang senantiasa berulang ternyata membangun kesadaran akan kehadiran [konsep] ruang, hingga pada titik tertentu menyibak nilai-nilai dasar dibaliknya, baik filosofis maupun spiritualitasnya. Darinya diperlihatkan bagaimana pengetahuan lokal itu jika dienkripsi dengan benar akan menghasilkan pengetahuan yang besar.
Modelling Business Agreements in the Multimodal Transportation Domain Through Ontological Smart Contracts
Authors: Scrocca Mario , Comerio Marco , Carenini Alessio , Celino Irene
Published: September 2022

The blockchain technology provides integrity and reliability of the information, thus offering a suitable solution to guarantee trustability in a multi-stakeholder scenario that involves actors defining business agreements. The Ride2Rail project investigated the use of the blockchain to record as smart contracts the agreements between different stakeholders defined in a multimodal transportation domain. Modelling an ontology to represent the smart contracts enables the possibility of having a machine-readable and interoperable representation of the agreements. On one hand, the underlying blockchain ensures trust in the execution of the contracts, on the other hand, their ontological representation facilitates the retrieval of information within the ecosystem. The paper describes the development of the Ride2Rail Ontology for Agreements to showcase how the concept of an ontological smart contract, defined in the OASIS ontology, can be applied to a specific domain. The usage of the designed ontology is discussed by describing the modelling as ontological smart contracts of business agreements defined in a ride-sharing scenario.
Public Health Assurance in the COVID-19 Era: Current Challenges and Future Prospects
Authors: Enitan Seyi Samson
Published: September 2022

If there is no any other time the subject of public health assurance should be discussed and taken more seriously, it is now, the COVID-19 ERA. The sudden outbreak of the COVID-19 pandemic in Wuhan province of China in December, 2019 has had tremendous impacts on various aspects of life across the world, including the health, economy, education and scientific research. Historically, public health has been a silver bullet for combating infectious diseases. The COVID-19 pandemic however, has further brought the need for public health assurance under global spotlight. Public Health Assurance covers those activities that deal with making sure people's health needs are safely and effectively met. Key areas of public health assurance include: 1) Enforcing laws and regulations that protect environmental health and ensure safety, 2) Linking people to needed environmental health services and assure the provision of environmental health services when otherwise unavailable, 3) Assuring a competent environmental health workforce, 4) Evaluating effectiveness, accessibility, and quality of personal and population-based environmental health services and 5) Researching for new insights and innovative solutions to environmental health problems. Challenges facing public health assurance include: 1) Inability to adequately perform the crucial public health tasks of evaluation, policy creation, and service assurance, 2) haphazard decision-making without the appropriate information and understanding, 3) Inequities in service provision and the advantages of public health, 4) Limitations on effective leadership, such as inadequate ties with the medical community and poor communication between the technical and political sides of decisions, inadequate creation of the knowledge required to address the full spectrum of public health demands, 6) Inadequate funding to support the delivery of public health services, and 7) public health workforce is understaffed and unequipped to meet the needs of local communities. COVID-19 has been and remains an unprecedented global crisis and public health systems have put tremendous efforts to withstand the pandemic with public health assurance. 

_KEY WORDS: COVID-19, Public Health Assurance, Challenges, Prospects_
Yeni Nesil Ev Pansiyonculuğu Sistemi Airbnb’nin Değerlendirilmesi: Swot Analizi
Authors: ÜNAL Arzu , DEMİRKOL Sehnaz
Published: September 2022

Turistik potansiyeli olan ülkelerde konaklamaya olan talebin her geçen gün artmasıyla çevrimiçi rezervasyon kanalları daha çok tercih edilmeye başlanmıştır. Ev pansiyonculuğu sisteminin dijital platforma taşınmış şekli olan Airbnb sistemi de son yıllarda tercih edilen alternatif konaklama seçeneklerindendir. Küresel düzeyde gelişen standartlar ve yaşanan pandemi süreci tüketici beklentilerini değiştirmiştir. Bu durum tüm işletmelerin rekabet ortamını arttırmıştır. Yaşanan yoğun rekabet ortamında işletmeler daha stratejik düşünmeli ve gerekli planlamaları yapmalıdır. Bu bağlamda SWOT analizi işletmeler için geleceğe yönelik hedeflere ulaşabilmek adına uygulanan stratejik bir yöntemdir. Çalışma kapsamında, Airbnb işletmesinin SWOT analizi yapılmış ve farklı araştırmalar için literatüre katkı sağlaması amaçlanmıştır. Analiz sonucunda sistemin konaklama sektörüne yeni bir boyut kazandırdığı ancak yasal ve güvenlik boşluklarının olduğu belirlenmiştir. Ayrıca uygulanan çevrimiçi platform, kopyalanabilen ve yeni iş fırsatları için potansiyel yaratan bir sistem olduğundan, sürekli güncellenmesi gerekliliği tespit edilmiştir.
Analisis Yuridis Terhadap Perlindungan Hukum Profesi Dokter Dalam Penyelesaian Sengketa Medis
Authors: Siregar Boy , Sahari Alpi , Fauzi Ahmad
Published: September 2022

Pembuktian seorang pecandu dan korban penyalahgunaan narkotika untuk direhabilitasi terbilang cukup sulit sebagaimana diatur dalam Undang-undang Nomor 35 Tahun 2009 tentang Narkotika, merupakan hal yang sulit, karena harus melihat awal pengguna narkotika menggunakan narkotika dan diperlukan pembuktian bahwa pengguna narkotika ketika menggunakan narkotika dalam kondisi dibujuk, diperdaya, ditipu, dipaksa, dan/atau diancam untuk menggunakan narkotika. Dalam implementasinya Mahkamah Agung mengeluarkan terobosan dengan mengeluarkan Surat Edaran (SEMA) Nomor 04 Tahun 2010 yang menjadi pegangan pertimbangan hakim dalam memutus narkotika. 2.      Pemikiran Double Track System menginginkan adanya kesetaraan antara Sanksi Pidana dan sanksi tindakan, tentu saja ini sangat perlu diterapkan bagi pelaku penyalahgunaan narkotika sekaligus sebagai pecandu narkotika, sehingga tentu saja ada efek jera dan proses penyembuhan dari pelaku kejahatan narkotika tersebut dapat berjalan, sehingga bagi para pelaku kejahatan narkotika dan dengan proses ini dilksanakan akan mampu untuk sembuh dari ketergantungan penggunaan Narkotika dan jera karena adanya sanksi pidana. Namun jika korban penyalahgunaan narkotika hanya perlu diberikan tindakan penyembuhan/rehabilitasi dari pemerintah.
KAJIAN HUKUM TERHADAP ORANG DISABILITAS YANG MENGGUNAKAN NARKOTIKA DALAM PRESFEKTIF KRIMINOLOGI (STUDI DI POLRESTABES MEDAN)
Authors: Taufik Harahap Asrul , Ediwarman Ediwarman , Eddy Triono
Published: September 2022

. Penyalahgunaan narkotika oleh penyandang disabilitas semakin merusak mental maupaun fisiknya, oleh karena itu perlu perhatian khusus dan tindakan kebijakan hukum dalam menghadapi dan menyelesaikan permasalahan ini agar tidak berkelanjutan. Untuk mengetahui penyebab terjadinya penyandang disabilitas menggunkan narkoba maka diperlukan penelitian mengenai faktor-faktornya dan akibat hukum apa yang akan terjadi bagi penyandang disabilitas tersebut. Hal ini akan ditinjau berdasarkan Undang-Undang No. 35 Tahun 2009 tentang Narkotika dan Undang-Undang No. 8 Tahun 2016 tentang  Penyandang Disabilitas Peneliitan ini dilakukan dengan metode penelitian deskriptif analisis, metode pendekatan yang digunakan ialah pendekatan undang-undang dan pendekatan konseptual. Teknik pengumpulan data bersumber dari library research dan field research di Polresrtabes Kota Medan dan Institusi Penerima Wajib Lapor (IPWL) Pusat Rehabilitas Korban Narkoba Mari Indonesia Bersinar, kemudian data tersebut dianalisis secara kualitatif. Berdasarkan hasil penelitian maka diketahui bahwa faktor-faktor penyhalahgunaan narkoba terhadap penyandang disabilitas ialah faktor kepribadian, keluarga, pendidikan, lingkungan dan ekonomi dan tidak percaya diri. Dampak dari penyalahgunaan narkotika oleh penyandang disabilitas bagi lingkungan masyarakat yaitu dampaknya sangat luas dan merupaakan ancaman serius terhadap berbagai aspek kehidupan dan kelangsungan hidup bangsa dan negara, masyarakat juga merasa terganggu dan terkait keluarganya mempengaruhi oleh pengguna narkotika tak terkecuali terhadap penyandang disabilitas. Upaya yang dilakukan Polrestabes Kota Medan dalam melakukan pencegahan dan penanggualangan narkotika ialah melakukan giat rutin GKN (Grebek Kampung Narkoba), melaksanakan penyuluhan secara rutin di wilayah rawan markoba, melakukan giat gotong royong di wilayah rawan narkoba, mengembangkan program Bersinar (Bersih Narkoba). Mendaftarkan diri atau korban ke Institusi Penerima Wajib Lapor (IPWL) Pusat Rehabilitas Korban Narkoba Mari Indonesia Bersinar sebagai wadah pemulihan. Polrestabes Kota Medan agar segera melakukan sosialisasi dan edukasi kepada masyarakat terakit hal tersebut agar tidak terjadi.
Pengaruh Keselamatan dan Kesehatan Kerja Perawat dalam Merawat Pasien Kanker Selama Masa Pandemi COVID-19
Authors: Diani Maria Tri , Flora Rostika , Syakurah Rizma Adlia
Published: September 2022

Pandemi COVID-19 menjadi perhatian utama khususnya bagi perawat kanker. Ini karena Pasien kanker sangat berisiko tinggi terkena infeksi. Perawat onkologi harus memastikan bahwa pasien yang mereka tangani menerima pelayanan perawatan yang optimal, sambil memastikan keselamatan diri mereka sendiri dan pasien mereka. Tujuan dari penelitian ini adalah agar dapat menganalisa pengaruh keselamatan dan kesehatan kerja tenaga perawat dalam merawat pasien kanker selama pandemi COVID-19. Metode yang digunakan oleh peneliti adalah systematic literature review dengan metode PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). Kombinasi kata kunci seperti Kesehatan kerja, cancer, COVID-19 digunakan untuk mencari jurnal sehingga 9 artikel jurnal terpilih. Dalam hal perawat onkologi melakukan triase pasien, menunda serta menyesuaikan perawatan dan juga membatasi akses pengunjung ke pasien merupakan cara baru untuk mencegah penyebaran COVID-19 ke pasien dan petugas kesehatan. Kekurangan tenaga kesehatan dan minimnya ketersediaan alat pelindung diri menjadi perhatian utama selama pandemi yang merupakan kebutuhan wajib dalam perencanaan atau Perawatan. Profesional kesehatan harus juga menyadari masalah ini dan mengadopsi perubahan dengan cepat. Dengan demikian, perawat dapat memimpin asuhan keperawatan yang tepat dan dapat melakukan intervensi untuk setiap pasien serta menetapkan batasan sosial selama pandemi ini perlu diperhatikan karena resikonya sanagat besar bagi tenaga kesehatan dan pasien agar tidak terjadi infeksi silang.
Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia
Authors: Lim Fang Qi , Chan Allison Si-Yu , Yokomori Rui , Huang Xiao Zi , Theardy Madelaine Skolastika , Yeoh Allen Eng Juh , Tan Shi Hao , Sanda Takaomi
Published: September 2022

T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of thymic T-cell precursors. Overexpression of oncogenic transcription factor TAL1 is observed in 40-60% of human T-ALL cases, frequently together with activation of the NOTCH1 and PI3K-AKT pathways. In this study, we performed chemical screening to identify small molecules that can inhibit the enhancer activity driven by TAL1 using the GIMAP enhancer reporter system. Among approximately 3,000 compounds, PIK- 75, a known inhibitor of PI3K and CDK, was found to strongly inhibit the enhancer activity. Mechanistic analysis demonstrated that PIK-75 blocks transcriptional activity, which primarily affects TAL1 target genes as well as AKT activity. TAL1-positive, AKT-activated T-ALL cells were very sensitive to PIK-75, as evidenced by growth inhibition and apoptosis induction, while T-ALL cells that exhibited activation of the JAK-STAT pathway were insensitive to this drug. Together, our study demonstrates a strategy targeting two types of core machineries mediated by oncogenic transcription factors and signaling pathways in T-ALL.
Análisis de la influencia del estrés laboral en el desempeño de los empleados del área de talento humano del Hospital General Portoviejo
Authors: Vera-Párraga Mariuxi , Pérez-Real Grether
Published: September 2022

El presente artículo tuvo como objetivo desarrollar un análisis de la influencia del estrés laboral en el desempeño de los empleados del área de talento humano del Hospital General Portoviejo, considerando que los problemas relacionados con la salud mental, tal y como el estrés, están afectando significativamente el desempeño o productividad de los trabajadores del siglo XXI, principalmente en el personal de salud durante y posterior a la pandemia de la covid19. Para alcanzar tal objetivo, se empleó el cuestionario de contenido trabajo (JCQ), que a través de una serie de preguntas busca construir un indicador de estrés laboral; y el Cuestionario de desempeño laboral individual (IWP). Obteniendo valores únicos para cada variable a través del cálculo de sus promedios, se aplicó un modelo de regresión lineal múltiple para determinar si existe correlación entre las variables planteadas. Lo resultados muestran que no existe relación estadísticamente significativa entre el estrés laboral y el desempeño de los trabajadores dentro del contexto analizado.
The Influence of Ibn Gabirol on John Duns Scotus' Metaphysics
Authors: ÇELEBİ Fırat
Published: September 2022

In his work Yanbu’ al-haya, the Jewish philosopher Ibn Gabirol, who lived in Andalusia in the eleventh century, lays the groundwork for his original philosophy. In the twelfth century, this work, with its translation into Latin under the name Fons vitae, influenced many philosophers in the tradition of Scholastic thought. The aim of this study is to examine the general lines of this work and to determine in which ways the thoughts in the work of the Jewish philosopher influenced John Duns Scotus, one of the important names of Scholastic thought. In this context, the basic thoughts of both thinkers about metaphysics were examined. As a result of this examination, it has been determined that John Duns Scotus was influenced by Ibn Gabirol in certain aspects in his views incorporeal substances, the plurality of forms and divine will.
Biomimetic, mussel-inspired surface modification of 3D-printed biodegradable polylactic acid scaffolds with nano-hydroxyapatite for bone tissue engineering
Authors: Chi Minghan , Li Na , Cui Junkui , Karlin Sabrina , Rohr Nadja , Sharma Neha , Thieringer Florian M.
Published: September 2022

Polylactic acid (PLA) has been widely used as filaments for material extrusion additive manufacturing (AM) to develop patient-specific scaffolds in bone tissue engineering. Hydroxyapatite (HA), a major component of natural bone, has been extensively recognized as an osteoconductive biomolecule. Here, inspired by the mussel-adhesive phenomenon, in this study, polydopamine (PDA) coating was applied to the surface of 3D printed PLA scaffolds (PLA@PDA), acting as a versatile adhesive platform for immobilizing HA nanoparticles (nHA). Comprehensive analyses were performed to understand the physicochemical properties of the 3D-printed PLA scaffold functionalized with nHA and PDA for their potent clinical application as a bone regenerative substitute. Scanning electron microscopy (SEM) and element dispersive X-ray (EDX) confirmed a successful loading of nHA particles on the surface of PLA@PDA after 3 and 7 days of coating (PLA@PDA-HA3 and PLA@PDA-HA7), while the surface micromorphology and porosity remain unchanged after surface modification. The thermogravimetric analysis (TGA) showed that 7.7 % and 12.3% mass ratio of nHA were loaded on the PLA scaffold surface, respectively. The wettability test indicated that the hydrophilicity of nHA-coated scaffolds was greatly enhanced, while the mechanical properties remained uncompromised. The 3D laser scanning confocal microscope (3DLS) images revealed that the surface roughness was significantly increased, reaching Sa (arithmetic mean height) of 0.402 μm in PLA@PDA-HA7. Twenty-eight days of in-vitro degradation results showed that the introduction of nHA to the PLA surface enhances its degradation properties, as evidenced by the SEM images and weight loss test. Furthermore, a sustainable release of Ca2+ from PLA@PDA-HA3 and PLA@PDA-HA7 was recorded, during the degradation process. In contrast, the released hydroxyl group of nHA tends to neutralize the local acidic environments, which was more conducive to osteoblastic differentiation and extracellular mineralization. Taken together, this facile surface modification provides 3D printed PLA scaffolds with effective bone regenerative properties by depositing Ca2+ contents, improving surface hydrophilicity, and enhancing the in-vitro degradation rate.
The role of RNA m6A methylation in lipid metabolism
Authors: Wang Yuting , Wang Yujie , Gu Jiarui , Su Tianhong , Gu Xiaosong , Feng Yu
Published: September 2022

The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metabolic regulation. The “writer” METTL3/METTL14 and the “eraser” FTO can promote the accumulation of lipids in various cells by affecting the decomposition and synthesis of lipids. The “reader” YTHDF recognizes m6A methylation sites of RNA and regulates the target genes’ translation. Due to this function that regulates lipid metabolism, RNA m6A methylation plays a pivotal role in metabolic diseases and makes it a great potential target for therapy.
Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis
Authors: Lisco Giuseppe , De Tullio Anna , Disoteo Olga , De Geronimo Vincenzo , Piazzolla Giuseppina , De Pergola Giovanni , Giagulli Vito Angelo , Jirillo Emilio , Guastamacchia Edoardo , Sabbà Carlo , Triggiani Vincenzo
Published: September 2022

Tirzepatide, a dual agonist of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide 1 (GLP-1) receptors, improved glucose control and reduced body weight in different therapeutic approaches. Herein, we overviewed the role of GIP and GLP-1 in the pathophysiology of type 2 diabetes and systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin in light of the results of the SURPASS-5 trial. We identified eleven randomized clinical trials. GLP-1 receptor agonists (GLP-1RAs) or Tirzepatide added to basal insulin than rigorously titrated basal insulin significantly ameliorates glucose control (Δ HbA1c = -1%, 95% CI -1.25; -0.74, I2 94%; Δ FPG = -14.6 mg/dL, 95% CI -21.6-; -7.6, I2 90%; chance to achieve HbA1c <7% = RR 2.62, 95% CI 2.10; 3.26, I2 89%), reduces body weight (Δ = -3.95 kg, 95% CI -5.1, -2.79, I2 96%) without increasing the risk of hypoglycemia (RR = 1.01, 95% CI 0.86; 1.18, I2 7.7%). Tirzepatide provides an impressive weight loss exceeding that observed with GLP-1RAs. Injectable incretin-based therapy plus basal insulin remains a potent and safe therapeutic approach in uncontrolled type 2 diabetes patients previously treated with basal insulin alone. Tirzepatide is expected to ameliorate the management of “diabesity” in this usually difficult-to-treat cluster of patients.
Analysis of HIF2α polymorphisms in infertile women with polycystic ovary syndrome or unexplained infertility
Authors: Zheng Xiaoya , Ma Jiani , Hu Min , Long Jian , Wei Qiang , Ren Wei
Published: September 2022

Objective

To evaluate HIF2α polymorphisms and glucose metabolism in a group of women with polycystic ovary syndrome (PCOS) or unexplained infertility (UI).

Patients

The infertile group (n=148) consisted of 96 women with PCOS, 52 women with UI, and176 women without infertility as a healthy control group.

Intervention

We genotyped 29 single nucleotide polymorphisms (SNPs) of HIF2α by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based genotyping technology. The genetic associations were analyzed statistically.

Main outcome measures

Allele frequency, genotype distribution and haplotype analyze of the HIF2α polymorphisms were performed. Body mass index (BMI), waist circumference, uric acid (UA), high-sensitivity C-reactive protein (hsCRP), lipids, glucose and insulin tolerance - were also measured.

Results

Infertile women with PCOS had a higherBMI and waist circumference, elevated hsCRP and uric acid (UA) levels, impaired glucose tolerance, and increased levels of plasma insulin compared to UI patients and healthy women. SNP analysis of HIF2α revealed that the allele and genotype frequencies of rs4953361 were significantly associated with infertile women with PCOS. Haplotype analysis of the HIF2α polymorphism identified haplotypes TGG and TGA as being associated with infertile women with PCOS. Women with the AA genotype of rs4953361 had a significantly higher BMI and post load plasma glucose and insulin levels than those of women with the GG genotype.

Conclusion

Infertile women with PCOS more commonly have metabolic disturbances than those with UI. This is the first study to report an association between HIF2α polymorphisms (rs4953361) and the risk of infertile women with PCOS, not UI, in Han Chinese population. These results require replication in larger populations.

In this observational study, we did not report the results of a health care intervention on human participants. The study was approved by the Human Research Ethics Committee of the First Affiliated Hospital of Chongqing Medical University. Clinical data and peripheral blood samples were collected only after explaining the objectives of the study and obtaining a signed informed consent form.
RETRACTED: Sustainable financial dimensions of managing poverty in the era of the COVID-19 pandemic: A developing country perspective
Authors: Lu Shaohua , Dai Junmin , Ali Anis , Al-Faryan Mamdouh Abdulaziz Saleh , Iqbal Nadeem
Published: September 2022

The COVID-19 pandemic is dangerous to people’s lives and livelihoods, creating immediate obstacles for organizations that support impacted populations. This research concentrates on the consequences for local microfinance institutions in Pakistan, which is a well-developed sector that has pulled many households out of the poverty trap. Microfinance programs in Pakistan provide financial resources to vulnerable and deprived people to engage in income-generating practices on more favorable terms. As a result, this study addressed and assessed the financial dimensions of managing poverty reduction in rural Pakistan through the microfinance segment and its effectiveness on poverty-reduction programs in Pakistan during the COVID-19 pandemic. The primary data were collected through a questionnaire survey to determine the views of the households, beneficiaries, and non-beneficiaries on the outcome and efficacy of poverty-reduction programs during the pandemic to meet the study objectives. The Mann-Whitney U test of the non-parametric method and Cronbach’s alpha of the data reliability test have been applied for the empirical analysis. According to the non-parametric findings, programs, marital status, working women members, and resources such as land, livestock, business assets, shares, and loans have all been affected during the COVID-19 pandemic. Education, wages, gender, size, child dependency, and district variables are significant factors related to poverty, but they fell into second position during COVID-19. These findings suggests that the small loan system must be improved and made efficient during the pandemic. This could be a practical tool to maintain poor people’s current economic and poverty position.
Inflammation and immunity connect hypertension with adverse COVID-19 outcomes
Authors: Cai Lei , He Chuan , Liu Yonglin , Sun Yanlan , He Lin , Baranova Ancha
Published: September 2022

Objectives: To explore the connection of hypertension and severe COVID-19 outcomes.

Methods: A total of 68 observational studies recording mortality and/or general severity of COVID-19 were pooled for meta-analyses of the relationship of severe COVID-19 outcomes with hypertension as well as systolic and diastolic blood pressure. Genome-wide cross-trait meta-analysis (GWCTM) was performed to explore the genes linking between hypertension and COVID-19 severity.

Results: The results of meta-analysis with the random effect model indicated that pooled risk ratios of hypertension on mortality and severity of COVID-19 were 1.80 [95% confidence interval (CI) 1.54–2.1] and 1.78 (95% confidence interval 1.56–2.04), respectively, although the apparent heterogeneity of the included studies was detected. In subgroup analysis, cohorts of severe and mild patients of COVID-19 assessed in Europe had a significant pooled weighted mean difference of 6.61 mmHg (95% CI 3.66–9.55) with no heterogeneity found (p = 0.26). The genes in the shared signature of hypertension and the COVID-19 severity were mostly expressed in lungs. Analysis of molecular networks commonly affected both by hypertension and by severe COVID-19 highlighted CCR1/CCR5 and IL10RB signaling, as well as Th1 and Th2 activation pathways, and also a potential for a shared regulation with multiple sclerosis.

Conclusion: Hypertension is significantly associated with the severe course of COVID-19. Genetic variants within inflammation- and immunity-related genes may affect their expression in lungs and confer liability to both elevated blood pressure and to severe COVID-19.
High FLT3 expression indicates favorable prognosis and correlates with clinicopathological parameters and immune infiltration in breast cancer
Authors: Chen Rui , Wang Xinyang , Fu Jingyue , Liang Mengdi , Xia Tiansong
Published: September 2022

Purpose: Breast cancer is a highly heterogeneous malignancy, seriously threatening female health worldwide and inducing higher mortalities. Few have the studies evaluated Fms-like TyrosineKinase-3 (FLT3) in prognostic risk, immunotherapy or any other treatment of breast cancer. Our study focused on investigating the function of FLT3 in breast cancer.

Patients and methods: Based on transcriptome and methylation data mined from The Cancer Gene Atlas (TCGA), we explored the clinical features of FLT3 expression in 1079 breast cancer samples. RT-qPCR in cell lines and tissue samples was used to verify the expression difference of FLT3. Kaplan–Meier survival analysis and cox regression models were employed for screening of FLT3 with potential prognostic capacity. Subsequently, functional analysis of the co-expressed genes was conducted using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene-set enrichment analysis (GSEA). The correlation between FLT3 expression and tumor immune infiltration was jointly analyzed with estimate, ssGSEA, TIMER, and TISIDB. Then we employed checkpoint-related molecules, immunophenoscore (IPS), and tumor mutation burden (TMB) to assess the efficacy of immuno-checkpoint inhibitors (ICIs). Pearson correlation coefficient was employed to exam the association between DNA methylation and FLT3 expression.

Results: FLT3 displays an elevated expression in breast cancer than normal pairs and is significantly associated with multiple clinical characteristics like age, menopause status, histological type, pathological stage, and molecular subtype as well as increased overall survival (OS). Additionally, FLT3 is a favorable independent prognostic factor. GO, KEGG, and GSEA suggested that FLT3 was associated with diversified immune-related features. FLT3 expression is correlated with the abundance of various immune cells namely CD4+T cell, CD8+ T cell, myeloid dendritic cell, and neutrophil as well as immune inhibitors especially CTLA4, which is positively correlated with FLT3 expression. Moreover, TMB displayed a negative correlation with FLT3 expression while IPS showed adverse tendency. Ultimately, the methylation of FLT3 downregulates the gene expression and closely binds to a few clinical parameters.

Conclusion: FLT3 can be used for prognostic prediction and is relevant to immune infiltration in breast cancer. FLT3 may pave the way for future novel immunotherapies.