bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prediction of Peritoneal Carcinomatosis in Patients with Colorectal Cancer Using Machine Learning
Authors: Bejan Valentin , Dragoi Elena-Niculina , Curteanu Silvia , Scripcariu Viorel , Filip Bogdan
Published: August 2022

The incidence of colon, rectal, and colorectal cancer is very high, and diagnosis is often made in the advanced stages of the disease. In cases where peritoneal carcinomatosis is limited, patients can benefit from newer treatment options if the disease is promptly identified, and they are referred to specialized centers. Therefore, an essential diagnostic benefit would be identifying those factors that could lead to early diagnosis. A retrospective study was performed using patient data gathered from 2010 to 2020. The collected data were represented by routine blood tests subjected to stringent inclusion and exclusion criteria. In order to determine the presence or absence of peritoneal carcinomatosis in colorectal cancer patients, three types of machine learning approaches were applied: a neuro-evolutive methodology based on artificial neural network (ANN), support vector machines (SVM), and random forests (RF), all combined with differential evolution (DE). The optimizer (DE in our case) determined the internal and structural parameters that defined the ANN, SVM, and RF in their optimal form. The RF strategy obtained the best accuracy in the testing phase (0.75). Using this RF model, a sensitivity analysis was applied to determine the influence of each parameter on the presence or absence of peritoneal carcinomatosis.
Novel Ultrasound-Guided Cervical Intervertebral Disc Injection of Platelet-Rich Plasma for Cervicodiscogenic Pain: A Case Report and Technical Note
Authors: Lam King Hei Stanley , Hung Chen-Yu , Wu Tsung-Ju , Chen Wei-Hung , Ng Tony Kwun Tung , Lin Jui-An , Wu Yung-Tsan , Lai Wai Wah
Published: August 2022

Ultrasound-guided needle placement into the cervical intervertebral discs using a lateral-to-medial approach is reportedly possible. Clinically, however, patients commonly present with very high uncovertebral joints or narrowed intervertebral spaces, making the method difficult or impossible. This report presents a novel ultrasound-guided needle placement technique to the cervical intervertebral discs using a more medial approach between the trachea/thyroid gland and the carotid sheath. A patient presented with neck pain radiating to the right shoulder and right-sided interscapular regions that affected his sleep and daily functioning. Physiotherapy, selective nerve root block, and percutaneous endoscopic right C7 laminotomy did not sufficiently improve his condition, which progressed to bilateral interscapular and bilateral shoulder pain. Provocative discography was performed with injection of leukocyte-poor and red blood cell-poor platelet-rich plasma to provoke the discogenic pain, which was treated with platelet-rich plasma mixed with lidocaine. The patient recovered well. A month later, there was a significant decrease in the neck disability index score from the initial 28/50 to 14, and there was a further decrease to 5 after 2 months. In conclusion, this medial approach of ultrasound-guided cervical disc needle placement is feasible, even in patients where disc access by previously described approaches is impossible.
Assessment of the Functional Capacity and Preparedness of the Haitian Healthcare System to Fight against the COVID-19 Pandemic: A Narrative Review
Authors: Faure Josemyrne Ashley , Wang Chia-Wen , Chen Chi-Hsin Sally , Chan Chang-Chuan
Published: August 2022

Low-income countries, such as Haiti, are facing challenges in fighting the COVID-19 pandemic due to resource shortages and fragile healthcare systems. This study assessed the functional capacity and preparedness of the Haitian healthcare system regarding the COVID-19 pandemic. It employed a narrative review approach to analyze secondary data and used the Donabedian model and the global health security index as the theoretical frameworks to evaluate preparedness. The findings reveal that Haiti faces challenges in tackling the COVID-19 pandemic due to a lack of biosafety and biosecurity regulations, inadequate laboratory systems for COVID-19 testing, and shortages of human resources and personal protective equipment. Moreover, poverty remains widespread, and people lack access to clean water and sanitation services, resulting in a high risk of COVID-19 infection. Furthermore, a lack of communication, rumors, the circulation of fake news regarding COVID-19, and stigmatization cause distrust and reduce the number of people seeking healthcare services. Haiti faces challenges with respect to tackling the pandemic. The Haitian government can strengthen and improve the capacity of the healthcare system to fight against the COVID-19 pandemic and infectious diseases emerging in the future.
Potentially Inappropriate Medications among Elderly with Frailty in a Tertiary Care Academic Medical Centre in Saudi Arabia
Authors: Alsaad Saad Mohammad , AlEraij Sheikah , Alsaad Abdulaziz Mohammed , AlSaif Haytham Ibrahim , Bawazeer Ghada
Published: August 2022

This study aims to assess the prevalence of potentially inappropriate medications (PIMs) and to analyze the relationship between the PIMs and frailty among inpatient older adults aged 65 and above in Saudi Arabia. A retrospective cross-sectional study design was utilized during the period between April 2021 and April 2022 of all patients aged 65 years and above admitted in a public tertiary hospital in Saudi Arabia. Data on the number of medications and the use of PIMs were assessed using Beers’ criteria while the frailty status was assessed using the “FRAIL Scale”. Of the 358 patient files that were reviewed, 52.2% were males, 60.9% were aged 65–74 years, and 82% were married. The prevalence of robust, prefrail, and frail patients was 5%, 36.9%, and 58.1%, respectively. According to the 2019 Beers criteria, a total of 45.8% (n = 164) participants identified as using PIMs. Compared to the non-PIMs group, the PIMs group demonstrated significant differences in the number of medications (p < 0.001), the number of comorbidities (p < 0.05), and the frailty score (p < 0.001). The strongest predictor of PIM use was a number of comorbidities, recording an odds ratio of 2.86, (95% CI 1.21–6.77, p < 0.05). Our results show that the use of PIM was significantly associated with frail older adults with multiple comorbidities and in patients with polypharmacy. A clear assessment and evaluation tool may improve the quality of drug treatment in the older adult population, particularly in frail patients.
Effect of Occupational Stress on Pharmacists’ Job Satisfaction in Saudi Arabia
Authors: Aldaiji Lamees , Al-jedai Ahmed , Alamri Abdulrahman , Alshehri Ahmed M. , Alqazlan Nouf , Almogbel Yasser
Published: August 2022

Work stress occurs when employees have to deal with pressures that do not align with their skills, knowledge, or expectations. This study aimed to assess the impact of work stress on job satisfaction among pharmacists in Saudi Arabia. Therefore, a cross-sectional, self-administered, paper-based survey was conducted between August 2019 and October 2020 using three scales. Descriptive and analytical statistical analyses were performed. A linear regression analysis was used to determine the relationship between occupational stress and job satisfaction among Saudi pharmacists. A total of 284 questionnaires were completed. Multiple linear regression analyses showed a significant negative relationship between occupational stress and job satisfaction (β = −0.456, 95% CI, −0.561 to −0.350), a positive relationship between confirmation and satisfaction (β = 0.147, 95% CI, 0.005 to –0.290), and a negative relationship between working in hospitals and job satisfaction (β= −3.009; 95% CI, −5.424 to −0.593) when other variables were kept constant. The results of this study indicated that occupational stress and satisfaction negatively influenced pharmacists, whereas confirmation was associated with better satisfaction. Moreover, hospital pharmacists had lower job satisfaction. The job satisfaction of pharmacists may help improve medication safety and ensure an adequate pharmacist workforce.
Development and Validation of a Novel Pre-Pregnancy Score Predictive of Preterm Birth in Nulliparous Women Using Data from Italian Healthcare Utilization Databases
Authors: Merlo Ivan , Cantarutti Anna , Allotta Alessandra , Tavormina Elisa Eleonora , Iommi Marica , Pompili Marco , Rea Federico , Agodi Antonella , Locatelli Anna , Zanini Rinaldo , Carle Flavia , Addario Sebastiano Pollina , Scondotto Salvatore , Corrao Giovanni
Published: August 2022

Background: Preterm birth is a major worldwide public health concern, being the leading cause of infant mortality. Understanding of risk factors remains limited, and early identification of women at high risk of preterm birth is an open challenge. Objective: The aim of the study was to develop and validate a novel pre-pregnancy score for preterm delivery in nulliparous women using information from Italian healthcare utilization databases. Study Design: Twenty-six variables independently able to predict preterm delivery were selected, using a LASSO logistic regression, from a large number of features collected in the 4 years prior to conception, related to clinical history and socio-demographic characteristics of 126,839 nulliparous women from Lombardy region who gave birth between 2012 and 2017. A weight proportional to the coefficient estimated by the model was assigned to each of the selected variables, which contributed to the Preterm Birth Score. Discrimination and calibration of the Preterm Birth Score were assessed using an internal validation set (i.e., other 54,359 deliveries from Lombardy) and two external validation sets (i.e., 14,703 and 62,131 deliveries from Marche and Sicily, respectively). Results: The occurrence of preterm delivery increased with increasing the Preterm Birth Score value in all regions in the study. Almost ideal calibration plots were obtained for the internal validation set and Marche, while expected and observed probabilities differed slightly in Sicily for high Preterm Birth Score values. The area under the receiver operating characteristic curve was 60%, 61% and 56% for the internal validation set, Marche and Sicily, respectively. Conclusions: Despite the limited discriminatory power, the Preterm Birth Score is able to stratify women according to their risk of preterm birth, allowing the early identification of mothers who are more likely to have a preterm delivery.
Exploring Conventional Economic Viability as a Potential Barrier to Scalable Urban Agriculture: Examples from Two Divergent Development Contexts
Authors: Kafle Arun , Hopeward James , Myers Baden
Published: August 2022

Urban Agriculture (UA) is the widespread practice of food production within available city space using non-commercial, commercial and hybrid production technologies. The economic viability of UA remains a concern among UA practitioners. To investigate UA’s viability; land, labour and distribution cost are analyzed, and margin and benefit–cost ratio (BCR) under vacant lot, rooftop/backyard and discretionary labour UA are calculated. We present a straightforward approach to gauge the economic viability of UA taking examples from 40 distinct locations of two divergent development contexts of Adelaide, South Australia and Kathmandu Valley, Nepal. UA seems potentially viable by selecting high-value crops in Adelaide but showed little chance of viability under low-value crop scenarios in both contexts. The high cost of land is shown to be the primary driver of cost for UA. Labour cost appears to be a critical difference between the two cities, being an important constraint for the economic viability in Adelaide, where the wage rate is high. To improve economic viability, the respective governments and planners should consider better ways to avail subsidised land through policy intervention and volunteer or subsidised labour arrangement mechanisms. Home food gardens accessing available land and labour as a discretionary/spare time activity with zero distribution cost may represent the best way to produce food without exceeding market costs in cities.
Google Earth Engine for Monitoring Marine Mucilage: Izmit Bay in Spring 2021
Authors: Kavzoglu Taskin , Goral Merve
Published: July 2022

Global warming together with environmental pollution threatens marine habitats and causes an increasing number of environmental disasters. Periodic monitoring of coastal water quality is of critical importance for the effective management of water resources and the sustainability of marine ecosystems. The use of remote sensing technologies provides significant benefits for detecting, monitoring, and analyzing rapidly occurring and displaced natural phenomena, including mucilage events. In this study, five water indices estimated from cloud-free and partly cloudy Sentinel-2 images acquired from May to July 2021 were employed to effectively map mucilage aggregates on the sea surface in the Izmit Bay using the cloud-based Google Earth Engine (GEE) platform. Results showed that mucilage aggregates started with the coverage of about 6 km² sea surface on 14 May, reached the highest level on 24 May and diminished at the end of July. Among the applied indices, the Adjusted Floating Algae Index (AFAI) was superior for producing the mucilage maps even for the partly cloudy image, followed by Normalized Difference Turbidity Index (NDTI) and Mucilage Index (MI). To be more specific, indices using green channel were found to be inferior for extracting mucilage information from the satellite images.
The Evaluation of Functional Abilities Using the Modified Fullerton Functional Fitness Test Is a Valuable Accessory in Diagnosing Men with Heart Failure
Authors: Migaj Magdalena , Kałużna-Oleksy Marta , Migaj Jacek , Straburzyńska-Lupa Anna
Published: July 2022

The assessment of functional abilities reflects the ability to perform everyday life activities that require specific endurance and physical fitness. The Fullerton functional fitness test (FFFT) seems to be the most appropriate for assessing physical fitness in heart failure (HF) patients. The study group consisted of 30 consecutive patients hospitalized for the routine assessment of HF with a reduced ejection fraction (HFrEF). They formed the study group, and 24 healthy subjects formed the control group. Each patient underwent a cardiopulmonary exercise test (CPET), transthoracic echocardiography and FFFT modified by adding the measurement of the handgrip force of the dominant limb with the digital dynamometer. The HF patients had significantly lower peak oxygen uptake (peakVO2), maximal minute ventilation, and higher ventilatory equivalent (VE/VCO2). The concentrations of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) were significantly higher in the study group. The results of all the FFFT items were significantly worse in the study group. FFFT parameters, together with the assessment of the strength of the handgrip, strongly correlated with the results of standard tests in HF. FFFT is an effective and safe tool for the functional evaluation of patients with HFrEF. Simple muscle strength measurement with a hand-held dynamometer can become a convenient and practical indicator of muscle strength in HF patients.
Emotional Intelligence, Interpersonal Relationships and the Role of Gender in Student Athletes
Authors: Mercader-Rubio Isabel , Gutiérrez Ángel Nieves , Oropesa Ruiz Nieves Fátima , Sánchez-López Pilar
Published: July 2022

The concept of emotional intelligence is related to the recognition of our own emotions, their regulation and our state of mind. Additionally, it is increasingly relevant in society in general, and in the field of sport in particular. The aim of this paper is to analyze the relationship between emotional intelligence and the theory of self-determination, specifically interpersonal relationships. For this purpose, sex was taken as a mediating variable, and a structural equation model was estimated through mediation. The sample was made up of a total of 165 active sportsmen and sportswomen who are studying undergraduate and master’s degree courses related to physical activity and sport sciences. The results show that gender acts as a mediating variable between emotional intelligence and relationships with others, becoming a mediating variable of two previously unrelated variables. The implications of these results lead us to study both emotional intelligence and its importance in the field of sport, as well as the fact of paying attention to the differences that may exist in this case depending on gender.
Adapting the WEPP Hillslope Model and the TLS Technology to Predict Unpaved Road Soil Erosion
Authors: Wang Yi , He Wei , Zhang Ting , Zhang Yani , Cao Longxi
Published: July 2022

Unpaved road erosion have been recognized as important sediment sources in a watershed. To evaluate where and when road erosion occurs, the soil loss along road segments should be precisely predicted with process-based erosion models. Methods: The hillslope version of the Water Erosion Prediction Project (WEPP) was used to estimate soil loss from 20 typical road segments in the red soil region of South China. Terrestrial laser scanning (TLS)-measured soil losses were used to validate the model simulations. The results showed that the WEPP model could reasonably predict the total soil loss in relatively short (less than 100 m) and gentle (slope gradient lower than 10%) road segments. In contrast, soil loss would be underestimated for long or steep road segments. Detailed outputs along roads revealed that most of the peak soil loss rates were underestimated. It might due to the linear critical shear stress theory in the WEPP model. Additionally, the lack of upstream flow was found to be connected to the relatively low model efficiency. Nevertheless, the WEPP simulation could accurately fit erosion trend and predict the peak soil loss positions along road segments. Conclusions: The WEPP model could be adopted to evaluate the erosion risk of unpaved roads in the red soil region of South China.
Corporate Social Responsibility: What Are Foodservice Companies Reporting?
Authors: Kim Minseong , Kim Ho-Seok
Published: July 2022

This study identified aspects of corporate social responsibility (CSR) activities using online communication tools (i.e., websites and online CSR reports) with an emphasis on the foodservice industry and compared quick-service restaurants and dessert cafes. With the content analysis of 48 foodservice companies, the community, environment, marketplace, vision and values, food, and workforce-centered CSR activities implemented by the selected foodservice companies were measured. In addition, the types CSR information delivered to customers employed by the foodservice companies were investigated. Lastly, there were significant differences between two segments in the foodservice industry in some aspects of CSR activities and types of CSR activities.
The Distribution of DOM in the Wanggang River Flowing into the East China Sea
Authors: Ma Jie , Pei Dongyan , Zhang Xuhan , Lai Qiuying , He Fei , Fu Chao , Liu Jianhui , Li Weixin
Published: July 2022

Dissolved organic matter (DOM) is a central component in the biogeochemical cycles of marine and terrestrial carbon pools, and its structural features greatly impact the function and behavior of ecosystems. In this study, the Wanggang River, which is a seagoing river that passes through Yancheng City, was selected as the research object. Three-dimensional (3D) fluorescence spectral data and UV–visible spectral data were used for component identification and source analysis of DOM based on the PARAFAC model. The results showed that the DOM content of the Wanggang River during the dry season was significantly higher than during the wet season; the DOM content increased gradually from the upper to lower reaches; the proportion of terrigenous components was higher during the wet season than during the dry. UV–Vis spectral data a280 and a355 indicated that the relative concentrations of protein-like components in the DOM of the Wanggang River were higher than those of humic-like components, and the ratio of aromatic substances in the DOM of the Wanggang River water was higher during the wet season. The DOM in the Wanggang River was dominated by protein-like components (>60%), and the protein-like components were dominated by tryptophan proteins (>40%). This study showed that the temporal and spatial distributions of DOM in rivers can be accurately determined using 3D fluorescence spectroscopy combined with the PARAFAC model. This provides useful insight into the biogeochemical process of DOM in rivers of coastal areas.
Optimal Decisions in a Multi-Party Closed-Loop Supply Chain Considering Green Marketing and Carbon Tax Policy
Authors: Lyu Shan , Chen Yuyu , Wang Lei
Published: July 2022

Global warming and e-waste pollution are two major environmental pollution issues that have attracted widespread attention. The government has adopted various measures to reduce carbon emissions from businesses and to make manufacturers responsible for recycling e-waste. In the face of external pressures, more and more companies are implementing sustainable closed-loop supply chain (CLSC) management to reduce environmental pollution and achieve sustainable development. Therefore, it is essential to study the operational decisions of CLSC enterprises. This paper considers a sustainable CLSC consisting of two competing manufacturers and a dominant retailer. The government imposes a carbon tax on the retailer, and two manufacturers collect used products directly from their customers. We separately examine whether implementing green marketing by the retailer and the collaboration between the two manufacturers can improve their profits. By building decentralized CLSC mathematical models and applying game theory methods, we obtain that green marketing can increase profits for all CLSC members and improve return rates. The collaboration may yield higher total profits for two manufacturers than a decentralized solution, while the retailer’s profits may be lost under certain conditions. Finally, we perform several numerical analyses to find the relationship between unit carbon emission tax and social welfare and gain some managerial insights. The study gives key factors that CLSC companies should consider when making decisions to help them achieve sustainability and provides recommendations for the government to set a reasonable unit carbon tax.
Level of Structural Integration and Its Association with Intersession Experiences and Outcomes: A Pilot Study
Authors: Gablonski Thorsten-Christian , Senft Birgit , Andreas Sylke
Published: July 2022

The level of structural integration (LSI), a psychodynamic/psychoanalytic concept originally developed by the Operationalized Psychodynamic Diagnosis (OPD), provides a promising empirical approach that is recognized beyond the boundaries of psychoanalysis and is highly relevant for therapy and research. The aim of our study was to investigate the intersession experiences of patients in psychotherapy with different levels of structural integration. The sample consisted of 69 inpatients who were undergoing psychotherapeutic treatment. The patients were asked to complete the German version of the Intersession Experience Questionnaire (IEQ), the short version of the OPD Structure Questionnaire (OPD-SQS) and the Brief-Symptom Inventory (BSI). LSI is associated with the situations, contents and negative emotions in the intersession experiences of patients, as well as their symptom distress over the course of therapy. Furthermore, the level of structural integration is a significant predictor of outcomes. Patients with different LSI had different intersession experiences.
Australian University Nursing and Allied Health Students’ and Staff Physical Activity Promotion Preparedness and Knowledge: A Pre-Post Study Using an Educational Intervention
Authors: Freene Nicole , Porra Katie , Bousie Jaquelin A. , Naunton Mark , Ball Nick , Flood Andrew , Bail Kasia , Smith Sally De-Vitry , Blenkin Milli , Cheong Lynn , Shanahan Madeleine , Isbel Stephen , Leung Myra , Gates Ann B.
Published: July 2022

The promotion of physical activity (PA) by health professionals is a key strategy to increase PA levels in the population. In this study, we investigated PA promotion, preparedness, and knowledge among university nursing and allied health students and staff, as well as PA resource usage within curricula, before and after an educational intervention. Students and staff from 13 health disciplines at one Australian university were invited to complete an online survey, and a curriculum audits were conducted before and after PA teaching resources were promoted by academic PA champions (n = 14). A total of 299 students and 43 staff responded to the survey pre-intervention, and 363 and 32 responded to the post-intervention, respectively. PA promotion role perception (≥93%) and confidence to provide general PA advice (≥70%) were high throughout the study. Knowledge of PA guidelines was poor (3–10%). Students of physiotherapy, sport and exercise science, as well as more active students, were more likely to be aware of the PA guidelines (p < 0.05). Over 12 months, PA promotion preparedness and knowledge did not change significantly, nor was there a change in the amount of PA content delivered, despite a significant increase in the use of the teaching resources across a number of disciplines (p = 0.007). Future research should be carried out to investigate the implementation of the resources over time and to develop additional strategies for PA promotion and education scaffolded across curricula.
Effects of a Mixed Exercise Program on Overweight and Obese Children and Adolescents: A Pilot, Uncontrolled Study
Authors: Pippi Roberto , Mascherini Gabriele , Izzicupo Pascal , Bini Vittorio , Fanelli Carmine Giuseppe
Published: July 2022

Pediatric excess weight has reached severity worldwide, affecting physical health. Decreasing weight and body mass index (BMI) after exercise intervention reduces the cardiometabolic consequences; the role of age and gender on the effectiveness of exercise in overweight youth was debated in this study. A total of 138 overweight/obese young (75 girls, 63 boys) were recruited at Perugia (Italy) University to follow an exercise program. Participants were allocated into two groups (children, n = 88 and adolescents, n = 50). The study aimed to verify the efficacy of a mixed resistance–endurance exercise program in anthropometric and physical performance measures, evaluating the influence of gender and age on two groups of young overweight/obese participants. In children, we observed a statistically significant improvement in fat mass percentage, fat-free mass, waist circumference (WC), fat mass, as well as in strength, endurance, speed, and flexibility measures. We also observed reduced WC and waist-to-height ratio (WHtR) values in girls. In the adolescents’ subgroup, results showed a statistically significant variation in fat mass percentage, BMI, WC, and WHtR, and strength of the upper and lower limbs; we also observed a weight reduction in girls. A clinical approach, with the combination of strength and dynamometric tests plus the body composition study using air plethysmography methodology, is health-effective and allows for the monitoring of the efficacy of an exercise program in overweight/obese young people.
How Does Hedonic Aroma Impact Long-Term Anxiety, Depression, and Quality of Life in Women with Breast Cancer? A Cross-Lagged Panel Model Analysis
Authors: Pereira Marta , Moreira Célia Sofia , Izdebski Pawel , Dias Alberto C. P. , Nogueira-Silva Cristina , Pereira M. Graça
Published: July 2022

Depression and anxiety are common symptoms during and after adjuvant chemotherapy treatment for breast cancer (BC), with implications on quality of life (QoL). The present study evaluates the temporal relationship between anxiety, depression, and QoL (primary outcomes), as well as the impact of hedonic aroma (essential oils) on this relationship. This is a secondary analysis of a previously reported randomized controlled trial, with two groups: an experimental group (n = 56), who were subjected to the inhalation of a self-selected essential oil during chemotherapy, and a control group (n = 56), who were only subjected to the standard treatment. The hedonic aroma intervention occurred in the second (T1), third (T2), and fourth (T3) chemotherapy sessions, three weeks apart from each other. The follow-up (T4) assessments took place three months after the end of the treatment. Cross-lagged panel models were estimated in the path analysis framework, using structural equation modeling methodology. Regarding the control group, the cross-lagged panel model showed that anxiety at T1 predicted anxiety at T3, which in turn predicted both QoL and depression at T4. In the experimental group, hedonic aroma intervention was associated with stability of anxiety and QoL over time from T1 to T3, with no longitudinal prediction at T4. For women undergoing standard chemotherapy treatment, anxiety was the main longitudinal precursor to depression and QoL three months after chemotherapy. Thus, essential oils could complement chemotherapy treatment for early-stage BC as a way to improve long-term emotional and QoL-related adjustment.
The Impact of COVID-19 on Dental Treatment in Kuwait—A Retrospective Analysis from the Nation’s Largest Hospital
Authors: AlHayyan Wasmiya Ali , AlShammari Khalaf , AlAjmi Falah , Pani Sharat Chandra
Published: July 2022

Background: The COVID-19 pandemic has changed the way dentistry has been practiced the world over. This study sought to assess the impact of the COVID-19 pandemic on the patterns of attendance for dental treatment in a large hospital in Kuwait through comparisons with data from the year prior to the pandemic. Methods: A total of 176,690 appointment records from 34,250 patients presenting to the AlJahra specialist hospital in Kuwait for dental treatment from April 2019 to March 2021 were analyzed. The types of procedures and the departments in which they presented were analyzed, and the patterns of attendance before and during the pandemic were compared. Results: While there was a significant reduction in the number of orthodontic, endodontic, and periodontal procedures, there were no impacts on oral surgery, restorative procedures, or pediatric dentistry. Conclusions: There has been a return in the number of patients obtaining dental treatment; however, there has been a definite shift in the use of certain dental procedures.
Environmental Radioactivity Monitoring and Measurements: Radon and Thoron
Authors: Janik Miroslaw
Published: July 2022

We “bathe” in radiation, which is an integral part of our environment [...]
Sedentary Behavior and Physical Inactivity in the Asia-Pacific Region: Current Challenges and Emerging Concerns
Authors: Annear Michael
Published: August 2022

This editorial sets the scene for our Special Issue on the growing problem of sedentary behavior and physical inactivity in the Asia-Pacific region. In many societies, more than 40% of the adult population and growing numbers of children are insufficiently physically active to safeguard their health. This is contributing to high rates of cardiovascular disease, obesity, and other deleterious health outcomes across the region. The Asia-Pacific is heterogeneous and complex, with diverse social, cultural, and environmental barriers that affect intentions and opportunities for regular physical activity. Recently, the problem has been compounded by the acceleration of population aging, the worsening effects of anthropogenic climate change, and the ongoing COVID-19 pandemic. Without strong leadership, enduring funding support, and innovative interventions that cut across policy and society, we may yet be facing a century of unmitigated expansion of morbidity across the Asia-Pacific.
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination
Authors: Schipani Fabrizio , Manerba Marcella , Marotta Roberto , Poppi Laura , Gennari Arianna , Rinaldi Francesco , Armirotti Andrea , Farabegoli Fulvia , Roberti Marinella , Di Stefano Giuseppina , Rocchia Walter , Girotto Stefania , Tirelli Nicola , Cavalli Andrea
Published: July 2022

The cytotoxic action of anticancer drugs can be potentiated by inhibiting DNA repair mechanisms. RAD51 is a crucial protein for genomic stability due to its critical role in the homologous recombination (HR) pathway. BRCA2 assists RAD51 fibrillation and defibrillation in the cytoplasm and nucleus and assists its nuclear transport. BRC4 is a peptide derived from the fourth BRC repeat of BRCA2, and it lacks the nuclear localization sequence. Here, we used BRC4 to (i) reverse RAD51 fibrillation; (ii) avoid the nuclear transport of RAD51; and (iii) inhibit HR and enhance the efficacy of chemotherapeutic treatments. Specifically, using static and dynamic light scattering, transmission electron microscopy, and microscale thermophoresis, we show that BRC4 eroded RAD51 fibrils from their termini through a “domino” mechanism and yielded monomeric RAD51 with a cumulative nanomolar affinity. Using cellular assays (BxPC-3, pancreatic cancer), we show that a myristoylated BRC4 (designed for a more efficient cell entry) abolished the formation of nuclear RAD51 foci. The present study provides a molecular description of RAD51 defibrillation, an essential step in BRCA2-mediated homologous recombination and DNA repair.
A New Method for Albuminuria Measurement Using a Specific Reaction between Albumin and the Luciferin of the Firefly Squid Watasenia scintillans
Authors: Ishimoto Tetsuya , Okada Takuya , Fujisaka Shiho , Yagi Kunimasa , Tobe Kazuyuki , Toyooka Naoki , Mori Hisashi
Published: July 2022

This study demonstrates that the luciferin of the firefly squid Watasenia scintillans, which generally reacts with Watasenia luciferase, reacted with human albumin to emit light in proportion to the albumin concentration. The luminescence showed a peak wavelength at 540 nm and was eliminated by heat or protease treatment. We used urine samples collected from patients with diabetes to quantify urinary albumin concentration, which is essential for the early diagnosis of diabetic nephropathy. Consequently, we were able to measure urinary albumin concentrations by precipitating urinary proteins with acetone before the reaction with luciferin. A correlation was found with the result of the immunoturbidimetric method; however, the Watasenia luciferin method tended to produce lower albumin concentrations. This may be because the Watasenia luciferin reacts with only intact albumin. Therefore, the quantification method using Watasenia luciferin is a new principle of urinary albumin measurement that differs from already established methods such as immunoturbidimetry and high-performance liquid chromatography.
An Adaptive Role for DNA Double-Strand Breaks in Hippocampus-Dependent Learning and Memory
Authors: Weber Boutros Sydney , Unni Vivek K. , Raber Jacob
Published: July 2022

DNA double-strand breaks (DSBs), classified as the most harmful type of DNA damage based on the complexity of repair, lead to apoptosis or tumorigenesis. In aging, DNA damage increases and DNA repair decreases. This is exacerbated in disease, as post-mortem tissue from patients diagnosed with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) show increased DSBs. A novel role for DSBs in immediate early gene (IEG) expression, learning, and memory has been suggested. Inducing neuronal activity leads to increases in DSBs and upregulation of IEGs, while increasing DSBs and inhibiting DSB repair impairs long-term memory and alters IEG expression. Consistent with this pattern, mice carrying dominant AD mutations have increased baseline DSBs, and impaired DSB repair is observed. These data suggest an adaptive role for DSBs in the central nervous system and dysregulation of DSBs and/or repair might drive age-related cognitive decline (ACD), MCI, and AD. In this review, we discuss the adaptive role of DSBs in hippocampus-dependent learning, memory, and IEG expression. We summarize IEGs, the history of DSBs, and DSBs in synaptic plasticity, aging, and AD. DSBs likely have adaptive functions in the brain, and even subtle alterations in their formation and repair could alter IEGs, learning, and memory.
Bombyx mori C-Type Lectin (BmIML-2) Inhibits the Proliferation of B. mori Nucleopolyhedrovirus (BmNPV) through Involvement in Apoptosis
Authors: Mei Xianghan , Li Chun , Peng Peilin , Wang Jue , He Enxi , Qiu Zhiyong , Xia Dingguo , Zhao Qiaoling , Shen Dongxu
Published: July 2022

C-type lectins (CTLs) are widely distributed in mammals, insects, and plants, which act as pattern recognition receptors (PRRs) to recognize pathogens and initiate immune responses. In this study, we identified a C-type lectin gene called BmIML-2 from the silkworm Bombyx mori. Its open reading frame (ORF) encodes 314 amino acids, which contain dual tandem C-type lectin-like domain (CTLD). BmIML-2 is highly expressed in the fat body and is significantly induced at 24 h after BmNPV infection. Moreover, overexpression of BmIML-2 dramatically inhibited the proliferation of BmNPV, and knockdown assay via siRNA further validated the inhibition of BmIML-2 on viral proliferation. In addition, transcript level detection of apoptosis-related genes and observation of apoptosis bodies implied that overexpression of BmIML-2 promoted BmNPV-induced apoptosis. Immunofluorescence analysis indicated that BmIML-2 distributed throughout the cytoplasm and was slightly concentrated in the cell membrane. Taken together, our results suggest that BmIML-2 could inhibit in the proliferation of BmNPV by facilitating cell apoptosis.
Wearable Sensor-Based Human Activity Recognition with Hybrid Deep Learning Model
Authors: Luwe Yee Jia , Lee Chin Poo , Lim Kian Ming
Published: August 2022

It is undeniable that mobile devices have become an inseparable part of human’s daily routines due to the persistent growth of high-quality sensor devices, powerful computational resources and massive storage capacity nowadays. Similarly, the fast development of Internet of Things technology has motivated people into the research and wide applications of sensors, such as the human activity recognition system. This results in substantial existing works that have utilized wearable sensors to identify human activities with a variety of techniques. In this paper, a hybrid deep learning model that amalgamates a one-dimensional Convolutional Neural Network with a bidirectional long short-term memory (1D-CNN-BiLSTM) model is proposed for wearable sensor-based human activity recognition. The one-dimensional Convolutional Neural Network transforms the prominent information in the sensor time series data into high level representative features. Thereafter, the bidirectional long short-term memory encodes the long-range dependencies in the features by gating mechanisms. The performance evaluation reveals that the proposed 1D-CNN-BiLSTM outshines the existing methods with a recognition rate of 95.48% on the UCI-HAR dataset, 94.17% on the Motion Sense dataset and 100% on the Single Accelerometer dataset.
Developing Bridge Deterioration Models Using an Artificial Neural Network
Authors: Althaqafi Essam , Chou Eddie
Published: August 2022

The condition of a bridge is critical in quality evaluations and justifying the significant costs incurred by maintaining and repairing bridge infrastructures. Using bridge management systems, the department of transportation in the United States is currently supervising the construction and renovations of thousands of bridges. The inability to obtain funding for the current infrastructures, such that they comply with the requirements identified as part of maintenance, repair, and rehabilitation (MR&R), makes such bridge management systems critical. Bridge management systems facilitate decision making about handling bridge deterioration using an efficient model that accurately predicts bridge condition ratings. The accuracy of this model can facilitate MR&R planning and is used to confirm funds allocated to repair and maintain the bridge network management system. In this study, an artificial neural network (ANN) model is developed to improve the bridge management system (BMS) by improving the prediction accuracy of the deterioration of bridge decks, superstructures, and substructures. A large dataset of historical bridge condition assessment data was used to train and test the proposed ANN models for the deck, superstructure, and substructure components, and the accuracy of these models was 90%, 90%, and 89% on the testing set, respectively.
Pentraxin 3 and Shigella LPS and IpaB Antibodies Interplay to Defeat Shigellosis
Authors: Meron-Sudai Shiri , Reizis Arava , Goren Sophy , Bialik Anya , Hochberg Amit , Cohen Dani
Published: July 2022

Shigella causes moderate to severe diarrhea or dysentery after invading the colon mucosa. Long Pentraxin 3 (PTX3) is recognized as the humoral component of the innate immune response to bacterial pathogens. We examined the interplay between levels of PTX3 and levels of anti-Shigella lipopolysaccharide (LPS) and anti-Shigella type 3 secretion system protein-IpaB antibodies in children during acute shigellosis and after recovery. PTX3 concentrations in serum and stool extracts were determined by sandwich ELISA using commercial anti-PTX3 antibodies. Serum IgG, IgM, and IgA anti-S. sonnei LPS or anti-S. sonnei IpaB were measured using in house ELISA. Children with acute shigellosis (n = 60) had elevated PTX3 levels in serum and stools as compared with recovered subjects (9.6 ng/mL versus 4.7 ng/mL, p < 0.009 in serum and 16.3 ng/g versus 1.1 ng/g in stool, p = 0.011). Very low levels of PTX3 were detected in stools of healthy children (0.3 ng/g). Increased serum levels of PTX3 correlated with high fever accompanied by bloody or numerous diarrheal stools characteristic of more severe shigellosis while short pentraxin; C-Reactive Protein (CRP) did not show such a correlation. PTX3 decreased in convalescence while anti-Shigella antibodies increased, switching the response from innate to adaptive toward the eradication of the invasive organism. These data can inform the development of Shigella vaccines and treatment options.
Efficacy of a Smartphone-Based Virtual Companion to Treat Insomniac Complaints in the General Population: Sleep Diary Monitoring Versus an Internet Autonomous Intervention
Authors: Philip Pierre , Dupuy Lucile , Sagaspe Patricia , de Sevin Etienne , Auriacombe Marc , Taillard Jacques , Micoulaud-Franchi Jean-Arthur , Morin Charles M.
Published: July 2022

(1) Background: Insomnia is the most prevalent sleep disorder worldwide and cognitive behavioral therapy is the front-line treatment. Digital health technologies have a role to play in screening and delivering interventions remotely and without the need for human intervention. The KANOPEE app, which provides a screening and behavioral intervention for insomnia symptoms through an interaction with a virtual agent, showed encouraging results in previous studies during and after the COVID-19 lockdown, but has not yet been evaluated in a controlled study. This study aims at comparing the benefits of KANOPEE, a smartphone application dealing with insomnia complaints, with another application proposing an electronic sleep diary named “My Sleep Diary”. The acceptance and potential benefits of these digital solutions are tested in real-life settings (i.e., without soliciting human medical resources) and in the general population. (2) Methods: Subjects were included if they downloaded one of the apps between December 2020 and October 2021, and were of legal age. Both apps were available on downloading platforms in France. Primary outcome was Insomnia Severity Index (ISI), and secondary outcomes were total sleep time (TST), sleep efficiency (SE) and wake time after sleep onset (WASO). (3) Results: A total of 535 users completed the intervention with KANOPEE and 489 users completed My Sleep Diary, both for 17 days. KANOPEE users improved their ISI score significantly more than sleep diary users (interaction Time*Group: F(2,2002) = 17.3, p < 0.001). Similar results were found for nocturnal sleep parameters (TST) (KANOPEE users gained 48 min of sleep after intervention, while My Sleep Diary users gained only 16 min of sleep), and particularly in the population with moderate to severe initial sleep complaints (F(4,1980) = 8.9, p < 0.001). Other sleep markers (SE and WASO) were significantly improved in the KANOPEE users compared to the sleep diary ones (p < 0.001). (4) Conclusions: KANOPEE provides significantly greater benefits than an electronic sleep diary regarding reduction of insomnia complaints and estimated nocturnal sleep characteristics in a self-selected sample of the general population. Population with the most severe initial ISI score (≥15) benefited the most from the KANOPEE App compared to filling up a simple sleep diary.
Non-Invasive Detection of Fibrotic NASH in NAFLD Patients with Low or Intermediate FIB-4
Authors: John Katharina , Franck Martin , Al Aoua Sherin , Rau Monika , Huber Yvonne , Schattenberg Joern M. , Geier Andreas , Bahr Matthias J. , Wedemeyer Heiner , Schulze-Osthoff Klaus , Bantel Heike
Published: July 2022

Background: Non-alcoholic steatohepatitis (NASH) and fibrosis are the main prognostic factors in non-alcoholic fatty liver disease (NAFLD). The FIB-4 score has been suggested as an initial test for the exclusion of progressed fibrosis. However, increasing evidence suggests that also NASH patients with earlier fibrosis stages are at risk of disease progression, emphasizing the need for improved non-invasive risk stratification. Methods: We evaluated whether the apoptosis biomarker M30 can identify patients with fibrotic NASH despite low or intermediate FIB-4 values. Serum M30 levels were assessed by ELISA, and FIB-4 was calculated in an exploration (n = 103) and validation (n = 100) cohort of patients with histologically confirmed NAFLD. Results: The majority of patients with low FIB-4 (cut-off value < 1.3) in the exploration cohort revealed increased M30 levels (>200 U/L) and more than 80% of them had NASH, mostly with fibrosis. NASH was also detected in all patients with intermediate FIB-4 (1.3 to 2.67) and elevated M30, from which ~80% showed fibrosis. Importantly, in the absence of elevated M30, most patients with FIB-4 < 1.3 and NASH showed also no fibrosis. Similar results were obtained in the validation cohort. Conclusions: The combination of FIB-4 with M30 enables a more reliable identification of patients at risk for progressed NAFLD and might, therefore, improve patient stratification.