bluuebunny/crossref_metadata_2025 huggingface dataset:
Higher risk of ACL rupture in amateur football compared to professional football: 5-year results of the ‘Anterior cruciate ligament-registry in German football’
Authors: Szymski Dominik , Achenbach Leonard , Zellner Johannes , Weber Johannes , Koch Matthias , Zeman Florian , Huppertz Gunnar , Pfeifer Christian , Alt Volker , Krutsch Werner
Published: September 2021

Purpose

Anterior cruciate ligament (ACL) injuries are a common severe type of football injury at all levels of play. A football-specific ACL registry providing both prospective ACL injury data according to the skill level and risk factors for ACL injury is lacking in the literature.

Methods

This study is based on the prospective ‘ACL registry in German Football’ implemented in the 2014–15 season. Professional (1st–3rd league), semi-professional (4th–6th league) and amateur leagues (7th league) were analysed regarding the incidence and risk factors for ACL injuries. Injuries were registered according to the direct reports of the injured players to the study office and double-checked via media analysis. After injury registration, the players received a standardised questionnaire. Data were analysed from the 2014–15 to the 2018–19 football season.

Results

Overall, 958 ACL injuries were registered during the 5-year study period. The incidence of ACL injuries was highest in amateur football (0.074/1000 h football exposure) compared to professional (0.058/1000 h; p < 0.0001) and semi-professional football (0.043/1000 h; p < 0.0001). At all skill levels, match incidence (professional: 0.343; semi-professional: 0.249; amateur: 0.319) was significantly higher than training incidence (professional: 0.015; semi-professional: 0.004; amateur: 0.005). Major risk factors were previous ACL injury (mean: 23.3%), other knee injuries (mean: 19.3%) and move to a higher league (mean: 24.2%).

Conclusion

This sports-specific ACL registry provides detailed information on the incidence and risk factors for ACL injuries in football over five years. Risk factors are skill level, match exposure, move to a higher league and previous knee injury. These factors offer potential starting points for screening at-risk players and applying targeted prevention.

Level of evidence

II.
On blow up for the energy super critical defocusing nonlinear Schrödinger equations
Authors: Merle Frank , Raphaël Pierre , Rodnianski Igor , Szeftel Jeremie
Published: September 2021

We consider the energy supercritical defocusing nonlinear Schrödinger equation $$\begin{aligned} i\partial _tu+\Delta u-u|u|^{p-1}=0 \end{aligned}$$

i

∂
t

u
+
Δ
u
-
u

|
u
|

p
-
1

=
0

in dimension $$d\ge 5$$

d
≥
5

. In a suitable range of energy supercritical parameters (d, p), we prove the existence of $${\mathcal {C}}^\infty $$

C

∞

well localized spherically symmetric initial data such that the corresponding unique strong solution blows up in finite time. Unlike other known blow up mechanisms, the singularity formation does not occur by concentration of a soliton or through a self similar solution, which are unknown in the defocusing case, but via a front mechanism. Blow up is achieved by compression for the associated hydrodynamical flow which in turn produces a highly oscillatory singularity. The front blow up profile is chosen among the countable family of $${\mathcal {C}}^\infty $$

C

∞

spherically symmetric self similar solutions to the compressible Euler equation whose existence and properties in a suitable range of parameters are established in the companion paper (Merle et al. in Preprint (2019)) under a non degeneracy condition which is checked numerically.
Modelling the potential ecological niche of domesticated buckwheat in China: archaeological evidence, environmental constraints and climate change
Authors: Krzyzanska Marta , Hunt Harriet V. , Crema Enrico R. , Jones Martin K.
Published: September 2021

We present a species distribution model (SDM) of Fagopyrum esculentum (buckwheat) in China using present distribution data and estimates for the past based on palaeoclimatic reconstructions. Our model estimates the potential area suitable for buckwheat cultivation over the last 8,000 years, with northeast China consistently showing the highest suitability, providing insights on the discrepancy between the location of the earliest archaeobotanical records in the area and its origins in southwest China based on biogeographic and genetic data. The model suggests little to no variation over time in the spatial extent of the potential area suitable for buckwheat cultivation. In the northern parts of China, the limits of the ecological niche largely fall within the borders of the study area, while to the west it never extends into the main Tibetan plateau, explaining the lack of fossil evidence from Central Asia. In the southwest, the niche overlaps with the borders of modern China, which supports this direction as a viable route of westward dispersal. The comparison between the prediction from the model and sites with archaeobotanical evidence for Fagopyrum indicates that the environmental niche it occupied remained stable over time. This may contrast with a dispersal pattern characterised by continuous adaptations to new environments facilitated by human activity, which may be suggested for other major and minor crops.
Nonlocal strong forms of thin plate, gradient elasticity, magneto-electro-elasticity and phase-field fracture by nonlocal operator method
Authors: Ren Huilong , Zhuang Xiaoying , Oterkus Erkan , Zhu Hehua , Rabczuk Timon
Published: September 2021

The derivation of nonlocal strong forms for many physical problems remains cumbersome in traditional methods. In this paper, we apply the variational principle/weighted residual method based on nonlocal operator method for the derivation of nonlocal forms for elasticity, thin plate, gradient elasticity, electro-magneto-elasticity and phase-field fracture method. The nonlocal governing equations are expressed as an integral form on support and dual-support. The first example shows that the nonlocal elasticity has the same form as dual-horizon non-ordinary state-based peridynamics. The derivation is simple and general and it can convert efficiently many local physical models into their corresponding nonlocal forms. In addition, a criterion based on the instability of the nonlocal gradient is proposed for the fracture modelling in linear elasticity. Several numerical examples are presented to validate nonlocal elasticity and the nonlocal thin plate.
Fat causes necrosis and inflammation in parenchymal cells in human steatotic liver
Authors: Wisse Eddie , Braet Filip , Shami Gerald J. , Zapotoczny Bartlomiej , Vreuls Celien , Verhaegh Pauline , Frederik Peter , Peters Peters J. , Olde Damink Steven , Koek Ger
Published: September 2021

Adapted fixation methods for electron microscopy allowed us to study liver cell fine structure in 217 biopsies of intact human livers over the course of 10 years. The following novel observations and concepts arose: single fat droplets in parenchymal cells can grow to a volume four times larger than the original cell, thereby extremely marginalizing the cytoplasm with all organelles. Necrosis of single parenchymal cells, still containing one huge fat droplet, suggests death by fat in a process of single-cell steatonecrosis. In a later stage of single-cell steatonecrosis, neutrophils and erythrocytes surround the single fat droplet, forming an inflammatory fat follicle indicating the apparent onset of inflammation. Also, fat droplets frequently incorporate masses of filamentous fragments and other material, most probably representing Mallory substance. No other structure or material was found that could possibly represent Mallory bodies. We regularly observe the extrusion of huge fat droplets, traversing the peripheral cytoplasm of parenchymal cells, the Disse space and the endothelium. These fat droplets fill the sinusoid as a sinusoidal lipid embolus. In conclusion, adapted methods of fixation applied to human liver tissue revealed that single, huge fat droplets cause necrosis and inflammation in single parenchymal cells. Fat droplets also collect Mallory substance and give rise to sinusoidal fat emboli. Therefore, degreasing of the liver seems to be an essential therapeutic first step in the self-repairing of non-alcoholic fatty liver disease. This might directly reduce single-cell steatotic necrosis and inflammation as elements in non-alcoholic steatohepatitis progression.
Sedentary work and participation in leisure–time physical activity
Authors: van As Sven , Beckers Debby G. J. , Veling Harm , Hooftman Wendela , Kompier Michiel A. J. , Geurts Sabine A. E.
Published: September 2021

Objective

Demanding psychosocial work characteristics, such as high job demands, can have a detrimental impact on leisure–time physical activity (LTPA), with adverse consequences for employee health and well-being. However, the mechanisms and moderators of this crossover effect are still largely unknown. We therefore aimed to identify and test potential mediating and moderating factors from within and outside the work environment. Based on the previous research, we expected job demands to be negatively related to LTPA through fatigue. In addition, we expected that job control and worktime control would attenuate the relationship between job demands and fatigue. Furthermore, we hypothesized that autonomous exercise motivation and spontaneous action planning would attenuate the relationship between fatigue and LTPA. In addition to these cross-sectional hypotheses, we expected the same effects to predict a change in LTPA in the following year.

Methods

To investigate these assumptions, a preregistered longitudinal survey study was conducted among a large sample of Dutch employees in sedentary jobs. Participants reported on the constructs of interest in 2017 and 2018 (N = 1189 and 665 respectively) and the resulting data were analyzed using path analyses.

Results

Our cross-sectional analyses confirm a weak indirect, negative association between job demands and LTPA, via fatigue. However, this finding was not observed in our longitudinal analyses and none of the other hypotheses were confirmed.

Conclusion

This study shows that, among employees with relatively healthy psychosocial work characteristics (i.e., high job control), the evidence for an impact of these work characteristics on participation in LTPA is limited.
Hypohydration produced by high-intensity intermittent running increases biomarkers of renal injury in males
Authors: Juett Loris A. , Midwood Katharine L. , Funnell Mark P. , James Lewis J. , Mears Stephen A.
Published: September 2021

Purpose

Whilst there is evidence to suggest that hypohydration caused by physical work in the heat increases renal injury, whether this is the case during exercise in temperate conditions remains unknown. This study investigated the effect of manipulating hydration status during high-intensity intermittent running on biomarkers of renal injury.

Methods

After familiarisation, 14 males (age: 33 ± 7 years; V̇O2peak: 57.1 ± 8.6 ml/kg/min; mean ± SD) completed 2 trials in a randomised cross-over design, each involving 6, 15 min blocks of shuttle running (modified Loughborough Intermittent Shuttle Test protocol) in temperate conditions (22.3 ± 1.0 °C; 47.9 ± 12.9% relative humidity). During exercise, subjects consumed either a volume of water equal to 90% of sweat losses (EU) or 75 mL water (HYP). Body mass, blood and urine samples were taken pre-exercise (baseline/pre), 30 min post-exercise (post) and 24 h post-baseline (24 h).

Results

Post-exercise, body mass loss, serum osmolality and urine osmolality were greater in HYP than EU (P ≤ 0.024). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were increased post-exercise (P ≤ 0.048), with greater concentrations in HYP than EU (HYP: 2.76 [1.72–4.65] ng/mOsm; EU: 1.94 [1.1–2.54] ng/mOsm; P = 0.003; median [interquartile range]). Osmolality-corrected urinary neutrophil gelatinase-associated lipocalin (uNGAL) concentrations were increased post-exercise (P < 0.001), but there was no trial by time interaction effect (P = 0.073).

Conclusion

These results suggest that hypohydration produced by high-intensity intermittent running increases renal injury, compared to when euhydration is maintained, and that the site of this increased renal injury is at the proximal tubules.
Alignment of safety and security risk assessments for modular production systems
Authors: Ehrlich Marco , Bröring Andre , Harder Dimitri , Auhagen-Meyer Torben , Kleen Philip , Wisniewski Lukasz , Trsek Henning , Jasperneite Jürgen
Published: September 2021

In order to ensure the safety and security of industrial systems with regard to all life cycle phases from development through operation to disposal, specific regulatory and normative requirements are imposed. Due to the digitalization, interconnection, and constantly increasing complexity of manufacturing systems in the context of Industrie 4.0, the manual effort necessary to achieve the required safety and security is becoming ever greater and almost impossible to manage, especially for small and medium-sized enterprises. Therefore, this paper examines the existing challenges in this area in more detail and gives an outlook on the possible solutions to ensure safety and security much quicker and with less manual effort. The overall vision is a (partially) automated risk assessment of modular systems with respect to safety and security, including the alignment of the corresponding processes from both domains and the formalization of the information models needed.
Two-valued number pyramids
Authors: Kastenholz Helmut
Published: September 2021

Number pyramids are common in elementary school mathematics. Trying to express the value of the top block in terms of the values at the base leads to the binomial coefficients. It also seems natural to ask for the maximal number of odd numbers in a number pyramid of a given size. The answer is easy to state, but the proof is nontrivial: A $$k$$
k
step number pyramid can have at most $$\left\lfloor\frac{k(k+1)+1}{3}\right\rfloor$$

k
(
k
+
1
)
+
1

3

odd numbers, which equals two thirds of the number of blocks rounded to the nearest integer. All maximal and almost maximal solutions are given explicitly. To this end, we rephrase the question in terms of colored tilings. In the outlook we present relations to other—mostly geometric—subjects and problems.
Hashimoto’s thyroiditis and coexisting disorders in correlation with HLA status—an overview
Authors: Mikosch Peter , Aistleitner Adrian , Oehrlein Markus , Trifina-Mikosch Eva
Published: September 2021

Hashimoto’s thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is a frequent disorder of the thyroid gland caused by autoimmune-trigged lymphocytic infiltration and destruction of the thyroid gland. With the progressive destruction of the organ, the thyroid gland shrinks in size, thus commonly leading to hypothyroidism. Therapy of HT is mainly focused on managing the thyroid dysfunction by oral substitution of L‑thyroxine. However, patients with HT often complain about a broad spectrum of symptoms, with some of them hardly explained by HT itself. Several other disorders are known to be associated with HT. The etiology of HT seems to be multifactorial, including environmental influences such as iodine supply, infections, and stress as triggers of immune modulation. In addition, also a genetic background based on changes of the human leukocyte antigen (HLA) status seems to be evident. The paper will provide an overview of diseases related to HT, including their correlation to certain HLA patterns. This presentation should give a broader view on HT-related disorders and facilitate detailed examination and management of patients with HT.
Welfare implications of mitigating investment uncertainty
Authors: Ogawa Takayuki , Sakamoto Jun
Published: September 2021

This study explores the welfare implications of mitigating investment uncertainty in the context of Easley and O’Hara (Rev Financ Stud 22:1817–1843, 2009) While one may expect welfare gains by encouraging participation in financial markets by ambiguity-averse investors, we formally show that it hurts other investors and thus is not Pareto-improving without appropriate income transfers. We also examine the welfare effects of income redistribution among heterogeneous investors and government spending on investor education.
Detailed 3D human body reconstruction from multi-view images combining voxel super-resolution and learned implicit representation
Authors: Li Zhongguo , Oskarsson Magnus , Heyden Anders
Published: September 2021

The task of reconstructing detailed 3D human body models from images is interesting but challenging in computer vision due to the high freedom of human bodies. This work proposes a coarse-to-fine method to reconstruct detailed 3D human body from multi-view images combining Voxel Super-Resolution (VSR) based on learning the implicit representation. Firstly, the coarse 3D models are estimated by learning an Pixel-aligned Implicit Function based on Multi-scale Features (MF-PIFu) which are extracted by multi-stage hourglass networks from the multi-view images. Then, taking the low resolution voxel grids which are generated by the coarse 3D models as input, the VSR is implemented by learning an implicit function through a multi-stage 3D convolutional neural network. Finally, the refined detailed 3D human body models can be produced by VSR which can preserve the details and reduce the false reconstruction of the coarse 3D models. Benefiting from the implicit representation, the training process in our method is memory efficient and the detailed 3D human body produced by our method from multi-view images is the continuous decision boundary with high-resolution geometry. In addition, the coarse-to-fine method based on MF-PIFu and VSR can remove false reconstructions and preserve the appearance details in the final reconstruction, simultaneously. In the experiments, our method quantitatively and qualitatively achieves the competitive 3D human body models from images with various poses and shapes on both the real and synthetic datasets.
Reflections on the Clinician’s Role with Individuals Who Self-identify as Transgender
Authors: Levine Stephen B.
Published: September 2021

The fact that modern patterns of the treatment of trans individuals are not based on controlled or long-term comprehensive follow-up studies has allowed many ethical tensions to persist. These have been intensifying as the numbers of adolescent girls declare themselves to be trans, have gender dysphoria, or are “boys.” This essay aims to assist clinicians in their initial approach to trans patients of any age. Gender identity is only one aspect of an individual’s multifaceted identity. The contributions to the passionate positions in the trans culture debate are discussed along with the controversy over the official, not falsifiable, position that all gender identities are inherently normal. The essay posits that it is relevant and ethical to investigate the forces that may have propelled an individual to create and announce a new identity. Some of these biological, social, and psychological forces are enumerated. Using the adolescent patient as an example, a model for a comprehensive evaluation process and its goals are provided. The essay is framed within a developmental perspective.
Multiomic Analyses of Dopaminergic Neurons Isolated from Human Substantia Nigra in Parkinson’s Disease: A Descriptive and Exploratory Study
Authors: Zaccaria Affif , Antinori Paola , Licker Virginie , Kövari Enikö , Lobrinus Johannes A. , Burkhard Pierre R.
Published: September 2021

Dopaminergic neurons (DA) of the substantia nigra pars compacta (SNpc) selectively and progressively degenerate in Parkinson’s disease (PD). Until now, molecular analyses of DA in PD have been limited to genomic or transcriptomic approaches, whereas, to the best of our knowledge, no proteomic or combined multiomic study examining the protein profile of these neurons is currently available. In this exploratory study, we used laser capture microdissection to extract regions from DA in 10 human SNpc obtained at autopsy in PD patients and control subjects. Extracted RNA and proteins were identified by RNA sequencing and nanoliquid chromatography–mass spectrometry, respectively, and the differential expression between PD and control group was assessed. Qualitative analyses confirmed that the microdissection protocol preserves the integrity of our samples and offers access to specific molecular pathways. This multiomic analysis highlighted differential expression of 52 genes and 33 proteins, including molecules of interest already known to be dysregulated in PD, such as LRP2, PNMT, CXCR4, MAOA and CBLN1 genes, or the Aldehyde dehydrogenase 1 protein. On the other hand, despite the same samples were used for both analyses, correlation between RNA and protein expression was low, as exemplified by the CST3 gene encoding for the cystatin C protein. This is the first exploratory study analyzing both gene and protein expression of laser-dissected neuronal parts from SNpc in PD. Data are available via ProteomeXchange with identifier PXD024748 and via GEO with identifier GSE 169755.
A simple method for decellularizing a cell-derived matrix for bone cell cultivation and differentiation
Authors: Weng Weidong , Zanetti Filippo , Bovard David , Braun Bianca , Ehnert Sabrina , Uynuk-Ool Tatiana , Histing Tina , Hoeng Julia , Nussler Andreas K. , Aspera-Werz Romina H.
Published: September 2021

The extracellular matrix regulates cell survival, proliferation, and differentiation. In vitro two-dimensional cell experiments are typically performed on a plastic plate or a substrate of a single extracellular matrix constituent such as collagen or calcium phosphate. As these approaches do not include extracellular matrix proteins or growth factors, they fail to mimic a complex cell microenvironment. The cell-derived matrix is an alternative platform for better representing the in vivo microenvironment in vitro. Standard decellularization of a cell-derived matrix is achieved by combining chemical and physical methods. In this study, we compared the decellularization efficacy of several methods: ammonium hydroxide, sodium dodecyl sulfate (SDS), or Triton X-100 with cold or heat treatment on a matrix of Saos-2 cells. We found that the protocols containing SDS were cytotoxic during recellularization. Heat treatment at 47 °C was not cytotoxic, removed cellular constituents, inactivated alkaline phosphatase activity, and maintained the levels of calcium deposition. Subsequently, we investigated the differentiation efficiency of a direct bone coculture system in the established decellularized Saos-2 matrix, an inorganic matrix of calcium phosphate, and a plastic plate as a control. We found that the decellularized Saos-2 cell matrix obtained by heat treatment at 47 °C enhanced osteoclast differentiation and matrix mineralization better than the inorganic matrix and the control. This simple and low-cost method allows us to create a Saos-2 decellularized matrix that can be used as an in vivo-like support for the growth and differentiation of bone cells.
Detection of Isopeptide Bonds in Monoclonal Antibody Aggregates
Authors: Powell Thomas , Knight Michael J. , Wood Amanda , O’Hara John , Burkitt William
Published: September 2021

Purpose

A major difficulty in monoclonal antibody (mAb) therapeutic development is product aggregation. In this study, intermolecular isopeptide bonds in mAb aggregates were characterized for the first time. We aim to propose a mechanism of covalent aggregation in a model antibody using stressed studies at raised temperatures to aid in the understanding of mAb aggregation pathways.

Methods

Aggregate fractions were generated using raised temperature and were purified using size-exclusion chromatography (SEC). The fractions were tryptically digested and characterized using liquid chromatography hyphenated to tandem mass-spectrometry (LC–MS/MS).

Results

An increased amount of clipping between aspartic acid and proline in a solvent accessible loop in the constant heavy 2 (CH2) domain of the mAb was observed under these conditions. Detailed peptide mapping revealed 14 isopeptide bonds between aspartic acid at that cleavage site and lysine residues on adjacent antibodies. Two additional isopeptide bonds were identified between the mAb HC N-terminal glutamic acid or a separate aspartic acid to lysine residues on adjacent antibodies.

Conclusions

Inter-protein isopeptide bonds between the side chains of acidic amino acids (aspartate and glutamate) and lysine were characterized for the first time in mAb aggregates. A chemical mechanism was presented whereby spontaneous isopeptide bond formation could be facilitated via either the aspartic acid side chain or C-terminus.
A Combined Experimental and Atomistic Investigation of PTFE Double Transfer Film Formation and Lubrication in Rolling Point Contacts
Authors: von Goeldel Stephan , Reichenbach Thomas , König Florian , Mayrhofer Leonhard , Moras Gianpietro , Jacobs Georg , Moseler Michael
Published: September 2021

Solid lubricants such as polytetrafluoroethylene (PTFE) are used in rolling-element bearings (REBs) when conventional lubrication (i.e. by fluids or greases) cannot be applied owing to extreme operating conditions (e.g. high temperatures or vacuum). Often a double transfer film mechanism is used with a cage acting as a lubricant reservoir resupplying the REB with solid lubricant by cage wear. An increase in service life of such bearings requires a better understanding of the transfer processes in the sliding and rolling contacts. Here, we investigate the effect of PTFE resupply on friction and lubricant film formation in a steel/steel and steel/glass rolling contact by tribometry and classical molecular dynamics (MD). A ball-on-disk tribometer is enhanced by a pin-on-disk sliding contact that transfers PTFE to the disk. The experiment allows simultaneous in situ measurement of friction and film thickness by white light interferometry in the rolling point contact. Increasing the pin load results in an increased PTFE film thickness in the rolling contact accompanied by a significant decrease in friction. To elucidate the observed film transfer and friction mechanism, sliding MD simulations with a newly developed density-functional-based, non-reactive force field for PTFE-lubricated iron oxide surfaces are performed. A strong adhesion of PTFE chains to iron oxide drives transfer film formation, whilst shear-induced chain alignment within PTFE results in reduced friction. The simulations reveal an anti-correlation between PTFE film thickness and friction coefficient—in agreement with the experiments. These investigations are a first step towards methods to control PTFE transfer film formation in REBs.

Graphic Abstract
Molecular epidemiology of respiratory syncytial virus among children and adults in India 2016 to 2018
Authors: Bandla Suresh S. , Devadiga Santhosha , Bhatt Rushil , Dsa Oliver C. , Govindakarnavar Arunkumar
Published: September 2021

Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections among children less than 5 years of age and the elderly. This study intended to determine the circulating genotypes of RSV among severe acute respiratory illness (SARI) cases during the period 2016–2018 in India, among hospitalized acute febrile illness cases of age ranging from 1 to 65 years. Throat/nasopharyngeal swab samples were subjected for testing RSV and subgroups by real-time reverse transcriptase polymerase chain reaction (RT-PCR), further sequencing and phylogenetic analysis were performed for the second hypervariable region of the G gene. RSV-A and B subtypes co-circulated during the years 2016, 2017, and 2018, with RSV-A as the dominant subtype in 2016, and RSV-B as the dominant subgroup in 2017 and 2018. Phylogenetic analysis revealed that the circulating genotypes of RSV were GA2 (16/16), of RSV-A, and GB5 (23/23) of RSV-B in the South, North, and Northeast region of India during the period between 2016 and 2018. Here we report the first study comprising the distribution of RSV-A and B genotypes in the different geographic regions of India among children and adults during the year 2016 to 2018. We also report GA2.3.7 lineage of GA2 genotype for the first time in India to the best of our knowledge.
Lung cancer and interstitial lung diseases: the lack of prognostic impact of lung cancer in IPF
Authors: Carobene Loredana , Spina Donatella , Disanto Maria Giulia , Micheletto Claudio , Mazzei Maria Antonietta , Paladini Piero , Ghiribelli Claudia , Bargagli Elena , Rottoli Paola
Published: September 2021

Lung Cancer (LC) is the first cause of death worldwide. Recently increased interest in interstitial lung diseases (ILD) has highlighted an association with lung cancer, offering interesting insights into the pathogenesis of the latter. Describe the association between lung cancer and ILD and evaluate the impact of LC on survival in these populations. We collected clinical, radiological, histologic data of 53 cases of advanced pulmonary fibrosis with lung cancer: 17 with UIP pattern (usual interstitial pneumonia, UIP/IPF-LC) and 36 with non-UIP pattern (ILD-LC). Adenocarcinoma was the most frequent histological subtype of lung cancer in all three groups and in UIP/IPF-LC developed in the lung periphery and in an advanced fibrosis context. Patients with DLCO% < 38% showed survival < 10 months, irrespective of group and development of carcinoma in UIP/IPF does not necessarily affect survival, unlike in SR-ILD. Our results confirm that the oncogenic mechanism is closely linked to fibrotic and inflammatory processes and that the development of carcinoma affects survival in SR-ILD but not in IPF.
Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke
Authors: Mori Takahisa , Yoshioka Kazuhiro , Tanno Yuhei
Published: September 2021

Background/purpose of the study

If non-alcoholic fatty liver disease (NAFLD) frequency is very high in stroke patients, NAFLD may be a risk factor for stroke and identifying factors of NAFLD presence may lead to stroke prevention. This retrospective study aimed to investigate whether NAFLD frequency was very high and identify factors associated with NAFLD presence at acute stroke admission.

Methods

We included stroke patients aged 40 − 79 years who (1) were admitted from 2016 to 2019, within 24 h of onset; (2) underwent abdominal ultrasonography; and (3) underwent blood examination of biomarkers. We evaluated the frequency and significant factors of NAFLD presence.

Results

Among 1672 stroke patients, 676 patients met our inclusion criteria, and 267 patients (39.5%) had NAFLD. Compared to patients without NAFLD, patients with NAFLD were young; had high anthropometric values; high blood pressure; low aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT) ratio; high levels of liver enzymes, serum albumin, HbA1c, and serum lipids; low-density lipoprotein; high serum level of some fatty acids; and high fatty acid% of palmitic acid (PA) and dihomo-gamma-linolenic acid (DGLA). After excluding variables with multicollinearity, independent NAFLD-presence factors were high body mass index (BMI), low AST/ALT ratio, high serum albumin level, high PA%, and high DGLA level.

Conclusions

The frequency of NAFLD was high in our patient group. Significant NAFLD-presence factors were high BMI, low AST/ALT ratio, high serum albumin level, high PA%, and high DGLA level. A further study is warranted to determine the effects of the NAFLD-presence factors on stroke onset or prevention.
Paleogene lake deep water sedimentary facies in the northern zone of the Chezhen Sag, Bohai Bay Basin, China
Authors: Yuanpei Zhang , Xuecai Zhang , Haifang Cao , Xugang Zheng , Jinkai Wang , Jinliang Zhang
Published: September 2021

This study researches an important genetic type of Paleogene sublacustrine fan deposits in widely developed glutenite bodies in the northern Chezhen Sag. The Paleogene sublacustrine fans in the Bohai Bay Basin are primarily distributed in Es3 (The third member of Paleogene Shahejie Formation). There are many sedimentary types in Chezhen depression, but understanding of the reservoir is too limited to support a development strategy. Therefore, a detailed study on the core characteristics, sedimentary structure, sedimentary microfacies and reservoir properties has been completed in order to reduce uncertainty. It is confirmed that the sublacustrine fan deposits are mostly characterized by a positive cycle of upward thinning, and the base is composed of conglomerate supporting conglomerate and massive gravel sandstone, which reflect the sedimentary characteristics of traction and gravity currents. Finally, the influence of sedimentary process on properties was assessed by establishing the correlation between microfacies and reservoir physical parameters, such as porosity, permeability, detrital particle. It is revealed that the sublacustrine fan glutenite body formed in the deep depression period is interspersed with deep- to semi-deep lake source rocks. The superior source–reservoir–caprock combination is one of the most important exploration targets in the northern zone.
Risk factors in bee and Vespula venom allergy: state of the art
Authors: Stoevesandt Johanna , Trautmann Axel
Published: September 2021

Background

Correct recognition of risk factors enables individualized management and treatment of venom allergic patients.

Methods

Systematic research and review of current literature regarding the risk of (1) severe sting-induced anaphylaxis, (2) anaphylactic adverse event during venom immunotherapy (VIT), and (3) treatment failure.

Results and discussion

(1) Mastocytosis is the most important risk factor for severe sting-induced anaphylaxis. Hereditary α‑tryptasemia was recently identified as a genetic predictor of severe reactions. Older age is clearly associated with an increased risk; the respective impact of defined cardiovascular comorbidities has yet to be determined. Recent data do not support an aggravation of venom-induced anaphylaxis by intake of β‑blockers or angiotensin-converting enzyme (ACE) inhibitors. A higher risk in men can be attributed to more intensive exposure to stinging insects. (2) Anaphylactic side effects of VIT are most common during the buildup phase, particularly in the course of (ultra-)rush protocols involving a high number of injections and high cumulative daily doses. They are significantly more frequent during honeybee compared to Vespula VIT. Data supporting a negative effect of mastocytosis on the tolerability of VIT are scarce. Older age and cardiovascular medication are not associated with a higher incidence of VIT-induced anaphylaxis. (3) Relapsing anaphylactic reactions to both field and challenge stings are significantly more common during and after honeybee compared to Vespula VIT. Reports of severe field-sting reactions in mastocytosis patients suggest an increased risk of treatment failure which may be overcome by higher maintenance doses and longer duration of VIT.
Staffing in a Level 1 Trauma Center: Quantifying Capacity for Preparedness
Authors: Woods Kaitlin , Hayanga J.W. Awori , Cannon Jeffrey , Lemons Wesley , Philips Michael , Schmidt Ashley , Boh Roosevelt , Noor Kinza , Fornaresio Lisa , Thibault Dylan , Martin PS , Wilson Alison , Hayanga Heather K.
Published: September 2021

Objective:

We sought to determine who is involved in the care of a trauma patient.

Methods:

We recorded hospital personnel involved in 24 adult Priority 1 trauma patient admissions for 12 h or until patient demise. Hospital personnel were delineated by professional background and role.

Results:

We cataloged 19 males and 5 females with a median age of 50-y-old (interquartile range [IQR], 35.5-67.5). The average number of hospital personnel involved was 79.71 (standard deviation, 17.62; standard error 3.6). A median of 51.2% (IQR, 43.4%-59.8%) of personnel were first involved within hour 1. More personnel were involved in direct versus indirect care (median 54.5 [IQR, 47.5-67.0] vs 25.0 [IQR, 22.0-30.5];P< 0.0001). Median number of health-care professionals and auxiliary staff were 74.5 (IQR, 63.5-90.5) and 6.0 (IQR, 5.0-7.0), respectively. More personnel were first involved in hospital locations external to the emergency department (median, 53.0 [IQR, 41.5-63.0] vs 27.5 [IQR, 24.0-30.0];P< 0.0001). No differences existed in total personnel by Injury Severity Score (P= 0.1266), day (P= 0.7270), or time of admission (P= 0.2098).

Conclusions:

A large number of hospital personnel with varying job responsibilities respond to severe trauma. These data may guide hospital staffing and disaster preparedness policies.
Shifting Standards of Judicial Review During the Coronavirus Pandemic in the United States
Authors: Mariner Wendy K.
Published: September 2021

Emergencies are exceptions to the rule. Laws that respond to emergencies can create exceptions to rules that protect human rights. In long lasting emergencies, these exceptions can become the rule, diluting human rights and eroding the rule of law. In the United States, the COVID-19 pandemic prompted states to change rules governing commercial and personal activities to prevent the spread of the coronavirus. Many governors’ executive orders were challenged as violations of the constitutionally protected rights of those affected. Judges are deciding whether emergencies can justify more restrictions than would be permitted in normal circumstances and whether some rights deserve more protection than others, even in an emergency. This article analyzes ongoing litigation involving emergency restrictions on religious freedom and access to reproductive health services. These cases suggest that some judges are altering the standards of judicial review of the state’s emergency powers in ways that could permanently strengthen some rights and dilute others in normal circumstances.
Numerical investigation of the wake bi-stability behind a notchback Ahmed body
Authors: He Kan , Minelli Guglielmo , Wang Jiabin , Dong Tianyun , Gao Guangjun , Krajnović Siniša
Published: September 2021

Large-eddy simulations are used to investigate the origin of the wake asymmetry and symmetry behind notchback Ahmed bodies. Two different effective backlight angles,

${\beta _1} = 17.8\mathrm{^\circ }$

and

${\beta _2} = 21.0\mathrm{^\circ }$

, are simulated resulting in wake asymmetry and symmetry in flows without external perturbations, in agreement with previous experimental observations. In particular, the asymmetric case presents a bi-stable nature showing, in a random fashion, two stable mirrored states characterized by a left or right asymmetry for long periods. A random switch and several attempts to switch between the bi-stability are observed. The asymmetry of the flow is ascribed to the asymmetric separations and reattachments in the wake. The deflection of the near-wall flow structures behind the slant counteracting the asymmetry drives the wake to be temporarily symmetric, triggering the switching process of the bi-stable wake. The consequence of deflection that forces the flow structure to form on the opposite side of the slant is the decisive factor for a successful switch. Modal analysis applying proper orthogonal decomposition is used for the exploration of the wake dynamics of the bi-stable nature observed.
Balanced ellipsoidal vortex equilibria in a background shear flow at finite Rossby number
Authors: McKiver William J.
Published: September 2021

We consider a uniform ellipsoid of potential vorticity (PV), where we exploit analytical solutions derived for a balanced model at the second order in the Rossby number, the next order to quasi-geostrophic (QG) theory, the so-called QG+1 model. We consider this vortex in the presence of an external background shear flow, acting as a proxy for the effect of external vortices. For the QG model the system depends on four parameters, the height-to-width aspect ratio of the vortex,

$h/r$

, as well as three parameters characterising the background flow, the strain rate,

$\gamma$

, the ratio of the background rotation rate to the strain,

$\beta$

, and the angle from which the flow is applied,

$\theta$

. However, the QG+1 model also depends on the PV, as well as the Prandtl ratio,

$f/N$

(

$f$

and

$N$

are the Coriolis and buoyancy frequencies, respectively). For QG and QG+1 we determine equilibria for different values of the background flow parameters for increasing values of the imposed strain rate up to the critical strain rate,

$\gamma _c$

, beyond which equilibria do not exist. We also compute the linear stability of this vortex to second-order modes, determining the marginal strain

$\gamma _m$

at which ellipsoidal instability erupts. The results show that for QG+1 the most resilient cyclonic ellipsoids are slightly prolate, while anticyclonic ellipsoids tend to be more oblate. The highest values of

$\gamma _m$

occur as

$\beta \to 1$

. For large values of

$f/N$

, changes in the marginal strain rates occur, stabilising anticyclonic ellipsoids while destabilising cyclonic ellipsoids.
Making “Tribes” in the Late Ottoman Empire
Authors: Barakat Nora Elizabeth
Published: September 2021

Oymak. Al. Boy. Cemaat. Taife. Aşiret. These are the terms Ottoman officials used in imperial orders (mühimme) to describe diverse human communities linked by their mobility and externality to village administration in Ottoman Anatolia between the sixteenth and eighteenth centuries. In 1924, Turkish historian Ahmet Refik compiled Ottoman imperial orders concerning such communities into a volume he titled Anadolu'da Türk Aşiretleri, 966–1200 (Turkish Tribes in Anatolia, 1560–1786). His use of the term aşiret (tribe) in the title is striking, because this term was only used in 9% of the orders in his volume (23 out of 244 total). However, by the late nineteenth century and in Refik's early Republican context, aşiret had become the standard term for these rural, extra-village, mobile human communities, which he understood as similar enough to include in his painstaking effort of compilation.
The Politics of Tribal Perseverance
Authors: Schmitz Charles
Published: September 2021

There is a short answer to the question that has been posed to the participants in this roundtable. Tribes have a great deal of currency in modern Yemen because they provide an effective means to govern and protect local society. Tribalism is a deep pool of widely accepted customary practices in Yemen that people draw upon to provide security, manage agricultural resources (Yemen's tribespeople are mostly settled agriculturalists), and resolve local disputes.
The Politics of Tribalization in Syria
Authors: Dukhan Haian
Published: September 2021

International media outlets have covered the news of Syrian tribes since the beginning of the protest movement that erupted in the country in 2011. This started with the “Friday of Tribes,” when Syrian tribes participating in protests against the Syrian regime in the Syrian city of Dar‘a began chanting “faz‘a” (chanting for support), which meant that they were seeking solidarity from other tribes for defense against the regime's aggression. As the Syrian uprising turned into a civil war that involved many players, some media outlets focused on the scenes of tribal leaders pledging allegiance to the Islamic State of Iraq and Syria (ISIS), or of others being summoned to Geneva, Switzerland, to hold talks with Western powers about the possibility of mobilizing against ISIS militants. One could only wonder exactly why tribal loyalties continued to play such a significant role in the everyday events of the Syrian civil war when many civil society advocates had argued that tribal affiliation in Syria had diminished.
First morphological and molecular identification of the cercaria of Stomylotrema vicarium from the endemic apple snail Pomacea americanista
Authors: Dellagnola Federico A. , Campoy-Diaz Alejandra D. , Vega Israel A.
Published: September 2021

The adult fluke Stomylotrema vicarium (Stomylotrematidae, Microphalloidea) was described for the first time in Theristicus caerulescens in 1901, but the complete life cycle has remained unknown to date. Here, we found a stomylotrematid trematode in the digestive gland of the endemic apple snail Pomacea americanista. The digestive gland's tubuloacini were compressed by the trematode larvae placed on connective tissues and haemocoel spaces. Non-virgulate, stylet-bearing cercariae showed three pairs of penetration glands with a body, oral sucker and stylet morphometrically similar to those of stylet-bearing, unencysted young metacercariae of S. vicarium found in the aquatic coleopteran Megadytes glaucus, and at a lesser extent with cercariae of S. gratiosus found in the apple snail Pomacea maculata. The larvae molecular phylogeny was inferred using the markers rRNA 28S and ITS1, being these sequences grouped with the sequences of S. vicarium obtained from adult flukes. Together, these findings indicate that the life cycle of S. vicarium begins in P. americanista, thus supporting the hypothesis that the ampullariid snails act as a first intermediate host.
A qualitative investigation of the psychosocial services utilised by care-givers of patients with Alzheimer's disease and related dementias in southwestern Uganda
Authors: Abaasa Catherine , Obua Celestino , Wakida Edith K. , Rukundo Godfrey Zari
Published: September 2021

Individuals with Alzheimer's disease and related dementias often require substantial support from other people. Much of the care-giving is from family members who eventually experience physical, emotional and financial stress, depression and fatigue. In Uganda, families are a cornerstone in providing care to individuals with dementia. However, little is known about the psychosocial supports available to the care-givers in their care-giving role. We assessed the psychosocial supports available to care-givers of individuals with Alzheimer's disease and related dementias in southwestern Uganda. We conducted 34 in-depth interviews at three referral hospitals at which care-givers identified by the treating clinicians were approached for informed consent. The interviews were conducted until thematic saturation was reached, and the interviews were translated and transcribed. Thematic content analysis was used to analyse the data. Care-giver supports were structured into two major themes: medical supports utilised and supports beyond the medical care system. Medical supports highlighted information provided by medical professionals. Supports beyond the medical care system included emotional and instrumental supports provided by religious leaders, the local communities and family members. Care-givers for individuals with dementia in southwestern Uganda receive educational support from medical practitioners, and unstructured emotional and instrumental supports from the family and community.