bluuebunny/crossref_metadata_2025 huggingface dataset:
Prisoner Re-entry
Authors: Treitler Peter C. , Angell Beth
Published: June 2020

Each year in the United States, more than 600,000 individuals transition from prisons back to the community upon release. This transition process, referred to as prisoner re-entry, is often fraught with challenges as individuals who in many cases already faced barriers to opportunity prior to incarceration are further marginalized because of the collateral consequences of incarceration. Common challenges experienced by released prisoners include difficulty securing stable housing and employment, limited social support, mental and physical health problems, barriers to social and political participation, and the stigma of a criminal record. Not surprising given the barriers to successful reintegration, recidivism rates are high, and more than half of released prisoners are re-incarcerated within five years. Although punitive approaches were dominant in the United States criminal justice system from the 1970s through the early 2000s, there has been a move toward a more rehabilitative approach since that time, resulting in policy changes that reduce incarceration and support reentry, and expansion of services for prisoners before and after release. Although relatively few social workers are employed in criminal justice settings, the ripple effects of incarceration on social and health outcomes imply that social workers employed in a wide variety of settings can expect to regularly encounter individuals who are at various points in the re-entry process, or families and significant others who are affected secondarily. Social workers will be better prepared to assist formerly incarcerated individuals with an awareness of the issues faced by this population, and the unique barriers they experience in accessing housing, employment, and other resources. This article therefore aims to provide an overview of prisoner re-entry, with a focus on matters relevant to social work researchers and practitioners. As a boundary-spanning profession, social work is ideally positioned to propel forward approaches that prioritize promoting social capital, strengthening communities that receive former prisoners, and adopting a strengths-based lens to rehabilitation and promoting desistance from crime.
The burden of psychotropic and anticholinergic medicines use in care homes: population-based analysis in 147 care homes
Authors: Grill Paula , Marwick Charis , De Souza Nicosha , Burton Jennifer Kirsty , Hughes Carmel , Guthrie Bruce
Published: June 2020

Background

older people living in care-homes are particularly vulnerable to adverse effects of psychotropic and anticholinergic drugs.

Methods

anonymised dispensed prescription data from all 4,478 residents aged ≥ 60 years in 147 care-homes in two Scottish health boards were analysed. Psychotropic medicines examined were antipsychotics, antidepressants, hypnotic/anxiolytics, opioids and gabapentinoids. Anticholinergic burden was measured using the modified anticholinergic risk scale (mARS). Variation between care-homes and associations with individual and care-home characteristics were examined using multilevel logistic regression.

Results

63.5% of residents were prescribed at least one psychotropic drug, and 27.0% two or more, most commonly antidepressants (41.6%), opioids (20.3%), hypnotic/anxiolytics (16.9%) and antipsychotics (16.7%). 48.1% were prescribed an anticholinergic drug, and 12.1% had high anticholinergic burden (mARS ≥ 3). Variation between care-homes was high for antipsychotics (intra-cluster correlation coefficient [ICC] 8.2%) and hypnotics/anxiolytics (ICC = 7.3%), and moderate for antidepressants (ICC = 4.7%) and anticholinergics (ICC = 2.8%). Prescribing of all drugs was lower in the oldest old. People with dementia were more likely to be prescribed antipsychotics (adjusted OR = 1.45, 95%CI 1.23–1.71) but less likely to be prescribed anticholinergics (aOR = 0.61, 95%CI 0.51–0.74). Prescribing of antipsychotics was higher in Tayside (aOR = 1.52, 95%CI 1.20–1.92), whereas prescribing of antidepressants (particularly tricyclic-related) was lower (aOR = 0.66, 95%CI 0.56–0.79). There was no association with care-home regulator quality scores.

Conclusion

care-home residents have high psychotropic and anticholinergic burden, with considerable variation between care-homes that is not related to existing measures of quality of care. Research to better understand variation between care-homes and the interaction with local prescribing cultures is needed.
Malpractice and Patient Safety Concerns
Authors: Reisch Lisa M , Flores Martiniano J , Radick Andrea C , Shucard Hannah L , Kerr Kathleen F , Piepkorn Michael W , Barnhill Raymond L , Elder David E , Knezevich Stevan R , Elmore Joann G
Published: June 2020

Objectives

“Assurance behaviors,” a type of defensive medicine, involve physicians’ utilization of additional patient services to avoid adverse legal outcomes. We aim to compare the use of clinical behaviors (such as ordering additional tests, services, and consultations) due to malpractice concerns with the same behaviors due to patient safety concerns.

Methods

A national sample of dermatopathologists (n = 160) completed an online survey.

Results

Participants reported using one or more of five clinical behaviors due to concerns about medical malpractice (95%) and patient safety (99%). Self-reported use of clinical behaviors due to malpractice concerns and patient safety concerns was compared, including ordering additional immunohistochemistry/molecular tests (71% vs 90%, respectively, P < .0001), recommending additional surgical sampling (78% vs 91%, P < .0001), requesting additional slides (81% vs 95%, P < .0001), obtaining second reviews (78% vs 91%, P < .0001), and adding caveats into reports regarding lesion difficulty (85% vs 89%, P > .05).

Conclusions

Dermatopathologists use many clinical behaviors both as assurance behaviors and due to patient safety concerns, with a higher proportion reporting patient safety concerns as a motivation for specific behaviors.
(Mono-) Exposure to Naphthalene in the Abrasives Industry: Air Monitoring and Biological Monitoring
Authors: Weiss Tobias , Breuer Dietmar , Bury Daniel , Friedrich Claudia , Werner Silke , Aziz Mohammed , Hummel Thomas , Raulf Monika , Zschiesche Wolfgang , Sucker Kirsten , Pallapies Dirk , Bünger Jürgen , Brüning Thomas
Published: June 2020

Exposure to the bicyclic aromatic hydrocarbon naphthalene occurs in most cases along with other polycyclic aromatic hydrocarbons. Here we report from an investigation of 63 healthy, non-smoking male employees in the abrasives industry where naphthalene is the only relevant chemical exposure. Exposure assessment was performed using a combination of Air and Biological Monitoring over nearly a whole working week (Mo.–Th.). Air measurements were carried out during the shift on Thursday with the GGP mini-sampling system, combining particle and vapour sampling at low flow rates. In urine spot samples, the metabolites 1- and 2-naphthol were measured Mo.–Th. pre- and post-shift (for the reference group only Mo. pre- and Th. post-shift). With regard to naphthalene concentrations measured in air and concentrations of its metabolites (1- and 2-naphthol) in urine, study participants could be divided into a high and a low exposure group, and a reference group. The naphthalene concentration in air was in the range of 0.1–11.6 mg m−3, and naphthol concentrations (sum of 1- and 2-naphthol) in post-shift urine were in the range of <1 to 10 127 µg l−1. Naphthalene concentrations in air and naphthol concentrations in urine were closely correlated, indicating mainly airborne exposure at the investigated workplaces. As expected from toxicokinetic data, internal body burden increased slightly during a working week and did not completely decline over a work-free weekend to background concentrations observed in occupationally not exposed persons. Taking into account the observed increase in pre- and post-shift values during the working week, urine sampling for Biological Monitoring at workplaces should be carried out after several preceding shifts. Our data allow the derivation of biological limit values for the sum of 1- and 2-naphthol in urine corresponding to occupational exposure limits for naphthalene in air.
Impact of genome duplication on secondary metabolite composition in non-cultivated species: a systematic meta-analysis
Authors: Gaynor Michelle L , Lim-Hing Simone , Mason Chase M
Published: June 2020

Background and Aims

Whole-genome duplication is known to influence ecological interactions and plant physiology; however, despite abundant case studies, much is still unknown about the typical impact of genome duplication on plant secondary metabolites (PSMs). In this study, we assessed the impact of polyploidy events on PSM characteristics in non-cultivated plants.

Methods

We conducted a systematic review and meta-analysis to compare composition and concentration of PSMs among closely related plant species or species complexes differing in ploidy level.

Key Results

We assessed 53 studies that focus on PSMs among multiple cytotypes, of which only 14 studies compared concentration quantitatively among cytotypes. We found that whole-genome duplication can have a significant effect on PSM concentration; however, these effects are highly inconsistent.

Conclusion

Overall, there was no consistent effect of whole-genome duplication on PSM concentrations or profiles.
Words Go Together Like ‘Bread and Butter’: The Rapid, Automatic Acquisition of Lexical Patterns
Authors: Conklin Kathy , Carrol Gareth
Published: June 2020

While it is possible to express the same meaning in different ways (‘bread and butter’ versus ‘butter and bread’), we tend to say things in the same way. As much as half of spoken discourse is made up of formulaic language or linguistic patterns. Despite its prevalence, little is known about how the processing system treats novel patterns and how rapidly a sensitivity to them arises in natural contexts. To address this, we monitored native English speakers’ eye movements when reading short stories containing existing (conventional) patterns (‘time and money’), seen once, and novel patterns (‘wires and pipes’), seen one to five times. Subsequently, readers saw both existing and novel phrases in the reversed order (‘money and time’; ‘pipes and wires’). In four to five exposures, much like existing lexical patterns, novel ones demonstrate a processing advantage. Sensitivity to lexical patterns—including the co-occurrence of lexical items and the order in which they occur—arises rapidly and automatically during natural reading. This has implications for language learning and is in line with usage-based models of language processing.
vmPFC Drives Hippocampal Processing during Autobiographical Memory Recall Regardless of Remoteness
Authors: McCormick Cornelia , Barry Daniel N , Jafarian Amirhossein , Barnes Gareth R , Maguire Eleanor A
Published: June 2020

Our ability to recall past experiences, autobiographical memories (AMs), is crucial to cognition, endowing us with a sense of self and underwriting our capacity for autonomy. Traditional views assume that the hippocampus orchestrates event recall, whereas recent accounts propose that the ventromedial prefrontal cortex (vmPFC) instigates and coordinates hippocampal-dependent processes. Here we sought to characterize the dynamic interplay between the hippocampus and vmPFC during AM recall to adjudicate between these perspectives. Leveraging the high temporal resolution of magnetoencephalography, we found that the left hippocampus and the vmPFC showed the greatest power changes during AM retrieval. Moreover, responses in the vmPFC preceded activity in the hippocampus during initiation of AM recall, except during retrieval of the most recent AMs. The vmPFC drove hippocampal activity during recall initiation and also as AMs unfolded over subsequent seconds, and this effect was evident regardless of AM age. These results recast the positions of the hippocampus and the vmPFC in the AM retrieval hierarchy, with implications for theoretical accounts of memory processing and systems-level consolidation.
Phage Therapy for Limb-threatening Prosthetic KneeKlebsiella pneumoniaeInfection: Case Report and In Vitro Characterization of Anti-biofilm Activity
Authors: Cano Edison J , Caflisch Katherine M , Bollyky Paul L , Van Belleghem Jonas D , Patel Robin , Fackler Joseph , Brownstein Michael J , Horne Bri’Anna , Biswas Biswajit , Henry Matthew , Malagon Francisco , Lewallen David G , Suh Gina A
Published: June 2020

Background

Prosthetic joint infection (PJI) is a potentially limb-threatening complication of total knee arthroplasty. Phage therapy is a promising strategy to manage such infections including those involving antibiotic-resistant microbes, and to target microbial biofilms. Experience with phage therapy for infections associated with retained hardware is limited. A 62-year-old diabetic man with a history of right total knee arthroplasty 11 years prior who had suffered multiple episodes of prosthetic knee infection despite numerous surgeries and prolonged courses of antibiotics, with progressive clinical worsening and development of severe allergies to antibiotics, had been offered limb amputation for persistent right prosthetic knee infection due to Klebsiella pneumoniae complex. Intravenous phage therapy was initiated as a limb-salvaging intervention.

Methods

The patient received 40 intravenous doses of a single phage (KpJH46Φ2) targeting his bacterial isolate, alongside continued minocycline (which he had been receiving when he developed increasing pain, swelling, and erythema prior to initiation of phage therapy). Serial cytokine and biomarker measurements were performed before, during, and after treatment. The in vitro anti-biofilm activity of KpJH46Φ2, minocycline and the combination thereof was evaluated against a preformed biofilm of the patient’s isolate and determined by safranin staining.

Results

Phage therapy resulted in resolution of local symptoms and signs of infection and recovery of function. The patient did not experience treatment-related adverse effects and remained asymptomatic 34 weeks after completing treatment while still receiving minocycline. A trend in biofilm biomass reduction was noted 22 hours after exposure to KpJH46Φ2 (P = .063). The addition of phage was associated with a satisfactory outcome in this case of intractable biofilm-associated prosthetic knee infection. Pending further studies to assess its efficacy and safety, phage therapy holds promise for treatment of device-associated infections.
Global evaluation of echocardiography in patients with COVID-19
Authors: Dweck Marc R , Bularga Anda , Hahn Rebecca T , Bing Rong , Lee Kuan Ken , Chapman Andrew R , White Audrey , Salvo Giovanni Di , Sade Leyla Elif , Pearce Keith , Newby David E , Popescu Bogdan A , Donal Erwan , Cosyns Bernard , Edvardsen Thor , Mills Nicholas L , Haugaa Kristina
Published: June 2020

Aims

To describe the cardiac abnormalities in patients with COVID-19 and identify the characteristics of patients who would benefit most from echocardiography.

Methods and results

In a prospective international survey, we captured echocardiography findings in patients with presumed or confirmed COVID-19 between 3 and 20 April 2020. Patient characteristics, indications, findings, and impact of echocardiography on management were recorded. Multivariable logistic regression identified predictors of echocardiographic abnormalities. A total of 1216 patients [62 (52–71) years, 70% male] from 69 countries across six continents were included. Overall, 667 (55%) patients had an abnormal echocardiogram. Left and right ventricular abnormalities were reported in 479 (39%) and 397 (33%) patients, respectively, with evidence of new myocardial infarction in 36 (3%), myocarditis in 35 (3%), and takotsubo cardiomyopathy in 19 (2%). Severe cardiac disease (severe ventricular dysfunction or tamponade) was observed in 182 (15%) patients. In those without pre-existing cardiac disease (n = 901), the echocardiogram was abnormal in 46%, and 13% had severe disease. Independent predictors of left and right ventricular abnormalities were distinct, including elevated natriuretic peptides [adjusted odds ratio (OR) 2.96, 95% confidence interval (CI) 1.75–5.05) and cardiac troponin (OR 1.69, 95% CI 1.13–2.53) for the former, and severity of COVID-19 symptoms (OR 3.19, 95% CI 1.73–6.10) for the latter. Echocardiography changed management in 33% of patients.

Conclusion

In this global survey, cardiac abnormalities were observed in half of all COVID-19 patients undergoing echocardiography. Abnormalities were often unheralded or severe, and imaging changed management in one-third of patients.
Incident atrial fibrillation and risk of psychoactive drug redemptions and psychiatric hospital contacts: a Danish Nationwide Register-based Follow-up Study
Authors: Hagengaard Louise , Polcwiartek Christoffer , Andersen Mikkel Porsborg , Sessa Maurizio , Krogager Maria Lukacs , Gislason Gunnar , Schou Morten , Torp-Pedersen Christian , Søgaard Peter , Kragholm Kristian Hay
Published: June 2020

Aims

To investigate whether incident atrial fibrillation or flutter (AF) diagnosis increases the risk of psychiatric outcomes compared with the general population.

Methods and results

First-time AF patients and population controls naive to psychiatric disease or filled prescriptions for psychotropic drugs were identified in Danish nationwide registries during 2005–14. AF patients were matched 1:2 with exposure density matching. Patients and controls were compared for 1-year cumulative incidences of depression, anxiety, and stress disorders, and for filled drug prescriptions for antidepressant, anxiolytic, selected antipsychotics, and hypnotics. Lastly, we examined 1-year cumulative incidences of a composite endpoint of the above-mentioned diagnoses or drug redemptions. We included 146 377 AF patients and 292 754 matched controls, 55% men and median age 74 (25–75% 65–82) years. AF patients had significantly higher cumulative incidences of composite endpoints. Furthermore, filled prescriptions for anxiolytics and hypnotics were significantly higher for AF patients compared with healthy population controls. The cumulative incidence of the composite endpoint was significantly higher in AF patients relative to controls 11.1% vs. 8.3%. For the composite endpoint, a significantly higher risk was apparent both in unadjusted (HR: 2.76, 95% CI: 2.67–2.85) and adjusted (HR: 2.51, 95% CI: 2.43–2.60) models for AF patients vs. controls in the first 3 months after study inclusion.

Conclusion

First-time AF patients were significantly more likely to have psychiatric outpatient or hospital contacts and to fill prescriptions for psychotropic drugs compared with healthy population controls. The risk was significantly elevated only during the first 3 months after AF diagnosis.
Host genotype explains rhizospheric microbial community composition: the case of wild cotton metapopulations (Gossypium hirsutum L.) in Mexico
Authors: Hernández-Terán Alejandra , Navarro-Díaz Marcelo , Benítez Mariana , Lira Rafael , Wegier Ana , Escalante Ana E
Published: June 2020

The rhizosphere provides several benefits to the plant host being a strong determinant for its health, growth and productivity. Nonetheless, the factors behind the assembly of the microbial communities associated with the rhizosphere such as the role of plant genotypes are not completely understood. In this study, we tested the role that intraspecific genetic variation has in rhizospheric microbial community assemblages, using genetically distinct wild cotton populations as a model of study. We followed a common garden experiment including five wild cotton populations, controlling for plant genotypes, environmental conditions and soil microbial community inoculum, to test for microbial differences associated with genetic variation of the plant hosts. Microbial communities of the treatments were characterized by culture-independent 16S rRNA gene amplicon sequencing with Illumina MiSeq platform. We analyzed microbial community diversity (alpha and beta), and diversity structure of such communities, determined by co-occurrence networks. Results show that different plant genotypes select for different and specific microbial communities from a common inoculum. Although we found common amplicon sequence variants (ASVs) to all plant populations (235), we also found unique ASVs for different populations that could be related to potential functional role of such ASVs in the rhizosphere.
The virulence factor urease and its unexplored role in the metabolism of Cryptococcus neoformans
Authors: Toplis Barbra , Bosch Caylin , Schwartz Ilan S , Kenyon Chris , Boekhout Teun , Perfect John R , Botha Alfred
Published: June 2020

Cryptococcal urease is believed to be important for the degradation of exogenous urea that the yeast encounters both in its natural environment and within the human host. Endogenous urea produced by the yeast's own metabolic reactions, however, may also serve as a substrate for the urease enzyme. Using wild-type, urease-deletion mutant and urease-reconstituted strains of Cryptococcus neoformans H99, we studied reactions located up- and downstream from endogenous urea. We demonstrated that urease is important for cryptococcal growth and that, compared to nutrient-rich conditions at 26°C, urease activity is higher under nutrient-limited conditions at 37°C. Compared to cells with a functional urease enzyme, urease-deficient cells had significantly higher intracellular urea levels and also showed more arginase activity, which may act as a potential source of endogenous urea. Metabolic reactions linked to arginase were also affected, since urease-positive and urease-negative cells differed with respect to agmatinase activity, polyamine synthesis, and intracellular levels of proline and reactive oxygen species. Lastly, urease-deficient cells showed higher melanin levels at 26°C than wild-type cells, while the inverse was observed at 37°C. These results suggest that cryptococcal urease is associated with the functioning of key metabolic pathways within the yeast cell.
Comparative studies of egg parasitoids of the pine processionary moth (Thaumetopoea pityocampa,Den. & Schiff.) in historic and expansion areas in France and Bulgaria
Authors: Georgiev Georgi , Rousselet Jérôme , Laparie Mathieu , Robinet Christelle , Georgieva Margarita , Zaemdzhikova Gergana , Roques Alain , Bernard Alexis , Poitou Laura , Buradino Maurane , Kerdelhue Carole , Rossi Jean-Pierre , Matova Maria , Boyadzhiev Peter , Mirchev Plamen
Published: June 2020

To investigate enemy pressure across the range of the pine processionary moth (Thaumetopoea pityocampa, Den. & Schiff.) as it spreads northwards in Europe because of climate change, a survey of 206 egg batches from historical and newly colonized areas at both the westernmost and the easternmost ends of the front was carried out in 2016–2018. Out of them, 97 egg batches were collected from nine locations in three regions in France and 109 from four localities in two regions in Bulgaria, both within historical and newly colonized ranges of the pest. The average number of eggs per batch collected in Bulgaria (226.6 ± 43.2) was higher than that in France (194.3 ± 50.1). However, the hatching percentage was higher in French samples, varying from 69.8 to 95.7, vs 49.8 to 85.2 per cent in Bulgarian samples. Four primary parasitoids (Ooencyrtus pityocampae, Baryscapus servadeii, Anastatus bifasciatus, Trichogramma sp.) and a hyperparasitoid (Baryscapus transversalis, found only in two regions of the historical range in Bulgaria) were identified. The oligophagous species B. servadeii was present at all sites within the historical range of the pest. In newly colonized areas, the impact of primary parasitoids on the host was distinctly low, suggesting that they lag behind the range expansion of pine processionary moth. In France, the most abundant species in the T. pityocampa parasitoid complex were B. servadeii in Ré Island and Orléans (97.3 and 87.4 per cent, respectively), and Trichogramma sp. (99.7 per cent) in a newly colonized locality in Fréhel. Ooencyrtus pityocampae prevailed in three of four Bulgarian localities (72.1 per cent in Sandanski, 89.7 per cent in Maglizh and 65.7 per cent in Sladak kladenets), whereas B. servadeii was the most abundant in Gega (75.4 per cent). Mortality of B. servadeii and O. pityocampae caused by the hyperparasitoid B. transversalis amounted to 4.8–6.2 per cent. The impact of predators on the pine processionary moth in the egg stage was negligible at most sites, reaching 12.5 per cent in only one site (Maglizh).
Chemoprevention of esophageal adenocarcinoma
Authors: Snider Erik J , Kaz Andrew M , Inadomi John M , Grady William M
Published: June 2020

Esophageal adenocarcinoma (EAC) is a major cause of cancer-related death, particularly in Western populations, and is rapidly rising in Asian populations at this time. Virtually all EACs develop from the precursor lesion Barrett’s esophagus (BE), which is the most significant risk factor for EAC. However, the rates of progression from BE to EAC are low and patients with BE are asymptomatic. Thus, any strategy for EAC prevention must carry a low risk of harm in order to be clinically useful. Since current EAC-screening and BE-surveillance methods carry some procedural risk and are burdensome, there is an opportunity for chemoprevention, i.e. medications or dietary factors that may prevent BE from progressing to EAC. A variety of candidate chemoprevention therapies have been assessed to date. Proton-pump inhibitors (PPIs) are the best studied and have modest EAC-chemoprevention efficacy in BE patients, with a recent randomized trial showing that high-dose PPI may be more effective than low-dose PPI. Aspirin and other non-steroidal anti-inflammatory drugs have moderate quality observational and randomized-trial evidence for preventing progression of BE to EAC, but their risks for harm have precluded their routine clinical use. Other therapies (statins, metformin, female sex hormones) generally do not have strong evidence to support their use in EAC chemoprevention. Although progress has been made in this field, there is still a need for more effective and safe chemoprevention therapies for EAC.
National Partnership to Improve Dementia Care in Nursing Homes Campaign: State and Facility Strategies, Impact, and Antipsychotic Reduction Outcomes
Authors: Crystal Stephen , Jarrín Olga F , Rosenthal Marsha , Hermida Richard , Angell Beth
Published: June 2020

Background and Objectives

Antipsychotic medications have been widely used in nursing homes to manage behavioral and psychological symptoms of dementia, despite significantly increased mortality risk. Use grew rapidly during the 2000s, reaching 23.9% of residents by 2011. A national campaign for safer dementia care in U.S. nursing homes was launched in 2012, with public reporting of quality measures, increased regulatory scrutiny, and accompanying state and facility initiatives. By the second quarter of 2019, use had declined by 40.1% to 14.3%. We assessed the impact of state and facility initiatives during the Campaign aimed at encouraging more-judicious prescribing of antipsychotic medications.

Research Design and Methods

Our mixed-methods strategy integrated administrative and clinical data analyses with state and facility case studies.

Results

Results suggest that substantial change in prescribing is achievable through sustained, data-informed quality improvement initiatives integrating educational and regulatory interventions, supported by public quality reporting. Adequate staffing, particularly of registered nurses, is key to support individualized management of symptoms through nonpharmacological strategies. Case study results suggest that state and facility initiatives during the campaign achieved considerable buy-in for the goal of more conservative prescribing, through a social process of normalization. Reporting and reduction of antipsychotic use was not followed by increases in sedative-hypnotic medication use. Rather, sedative-hypnotic use declined in tandem with antipsychotic reduction, suggesting that increased attention to prescribing patterns led to more cautious use of other risky psychotropic medications.

Discussion and Implications

Quality improvement initiatives to change entrenched but problematic clinical practices face many barriers to success, including provider-level inertia; perceptions that alternatives are not available; and family and staff resistance. Nevertheless, systemic change is possible through concerted, collaborative efforts that touch prescribing practices at multiple points; integrate educational and regulatory influences; activate local and state champions for improvement; foster reputational influences through public reporting and benchmarking; and support a social process of normalization of preferred care processes as a best practice that is in the interest of patients.
Fromcontrollingtoconnecting: M’Wikwedong as a place of urban Indigenous health promotion in Canada
Authors: Sanchez-Pimienta Carlos E , Masuda Jeff ,   M'Wikwedong Indigenous Friendship Centre
Published: June 2020

In recent years, health promotion has come under critique for being framed according to the contexts and priorities of Western communities, with the notion of ‘control’ underpinning much of its theoretical and practical development. Ceding space to Indigenous voices and knowledge is one way forward to overcoming this limitation and decolonizing the field. This paper reports on insights gained from a participatory digital storytelling project focused on Indigenous health promotion that took place at M’Wikwedong Indigenous Friendship Centre in the city of Owen Sound, Canada. The research team was formed by M’Wikwedong’s Executive Director, five Indigenous youth and two university researchers. We co-created data through an 8-month digital storytelling process that involved 13 weekly research meetings, the creation of 4 digital stories and video screenings. We analysed data from seven group interview transcriptions, field notes and video transcripts through qualitative coding and theme building. The four themes we identified speak to the ways M’Wikwedong reinforced connections to youth, their sense of self, place in the city and Indigenous cultures. From our findings, we theorize that egalitarianism of knowledge, restoring balance in relationships and Indigenous leadership are core components of an ‘ethos of connection’ that underlies Indigenous health promotion. The ‘ethos of connection’ challenges Western notions of ‘control’ and brings attention to the unique expertise and practices of urban Indigenous communities and organizations as a primary basis for health promotion.
A combination of species distribution and ocean-biogeochemical models suggests that climate change overrides eutrophication as the driver of future distributions of a key benthic crustacean in the estuarine ecosystem of the Baltic Sea
Authors: Gogina Mayya , Zettler Michael L , Wåhlström Irene , Andersson Helén , Radtke Hagen , Kuznetsov Ivan , MacKenzie Brian R
Published: June 2020

Species in the brackish and estuarine ecosystems will experience multiple changes in hydrographic variables due to ongoing climate change and nutrient loads. Here, we investigate how a glacial relict species (Saduria entomon), having relatively cold, low salinity biogeographic origin, could be affected by the combined scenarios of climate change and eutrophication. It is an important prey for higher trophic-level species such as cod, and a predator of other benthic animals. We constructed habitat distribution models based occurrence and density of this species across the entire Baltic and estimated the relative importance of different driving variables. We then used two regional coupled ocean-biogeochemical models to investigate the combined impacts of two future climate change and nutrient loads scenarios on its spatial distribution in 2070–2100. According to the scenarios, the Baltic Sea will become warmer and fresher. Our results show that expected changes in salinity and temperature outrank those due to two nutrient-load scenarios (Baltic Sea Action Plan and business as usual) in their effect on S. entomon distribution. The results are relatively similar when using different models with the same scenarios, thereby increasing the confidence of projections. Overall, our models predict a net increase (and local declines) of suitable habitat area, total abundance and biomass for this species, which is probably facilitated by strong osmoregulation ability and tolerance to temperature changes. We emphasize the necessity of considering multiple hydrographic variables when estimating climate change impacts on species living in brackish and estuarine systems.
The effect of compressibility on the behaviour of filter media
Authors: Köry Jakub , Krupp Armin U , Please Colin P , Griffiths Ian M
Published: June 2020

A filter comprises porous material that traps contaminants when fluid passes through under an applied pressure difference. One side effect of this applied pressure, however, is that it compresses the filter. This changes the permeability, which may affect its performance. As the applied pressure increases, the flux of fluid processed by the filter will also increase but the permeability will decrease. Eventually, the permeability reaches zero at a point in the filter and the fluid flux falls to zero. In this paper, we derive a model for the fluid transport through a filter due to an applied pressure difference and the resulting compression. We use this to determine the maximum operating flux that can be achieved without the permeability reaching zero and the filter shutting down. We determine the material properties that balance the desire to maximize flux while minimizing power use. We also show how choosing an initial spatially dependent permeability can lead to a uniformly permeable filter under operation and we find the permeability distribution that maximizes the flux for a given applied pressure, both of which have desirable industrial implications. The ideas laid out in this paper set a framework for modelling more complex scenarios such as filter blocking.
Regularity Properties of Free Multiplicative Convolution on the Positive Line
Authors: Ji Hong Chang
Published: June 2020

Given two nondegenerate Borel probability measures $\mu$ and $\nu$ on ${\mathbb{R}}_{+}=[0,\infty )$, we prove that their free multiplicative convolution $\mu \boxtimes \nu$ has zero singular continuous part and its absolutely continuous part has a density bounded by $x^{-1}$. When $\mu$ and $\nu$ are compactly supported Jacobi measures on $(0,\infty )$ having power law behavior with exponents in $(-1,1)$, we prove that $\mu \boxtimes \nu$ is another Jacobi measure whose density has square root decay at the edges of its support.
Unveiling the Risk Period for Death After Respiratory Syncytial Virus Illness in Young Children Using a Self-Controlled Case Series Design
Authors: Li You , Campbell Harry , Nair Harish ,   RESCEU Investigators, Nair Harish , Campbell Harry , Li You , Reeves Rachel M , Douglas Anne , Meijer Adam , Fischer Thea Kølsen , Heikkinen Terho , Giaquinto Carlo , Swanson Kena , Stoszek Sonia , Leach Amanda , Demont Clarisse , Gallichan Scott , Aerssens Jeroen , Beutels Philippe , Bont Louis , Pollard Andrew , Openshaw Peter , Abram Michael , Rosen Brian , Molero Eva , Nair Harish , Campbell Harry , Li You , Reeves Rachel M , Douglas Anne , Meijer Adam , Fischer Thea Kølsen , Heikkinen Terho , Giaquinto Carlo , Swanson Kena , Stoszek Sonia , Leach Amanda , Demont Clarisse , Gallichan Scott , Aerssens Jeroen , Beutels Philippe , Bont Louis , Pollard Andrew , Openshaw Peter , Abram Michael , Rosen Brian , Molero Eva
Published: June 2020

Background

Respiratory syncytial virus (RSV)–related acute lower respiratory infection is an important cause of death in infants and young children. However, little is known about the risk period for RSV-related deaths after presentation to health services with an RSV illness.

Methods

Using the Scottish national mortality database, we identified deaths from respiratory/circulatory causes (hereafter “respiratory/circulatory deaths”) in young children aged <5 years during 2009–2016, whose medical history and records of laboratory-confirmed RSV infections were obtained by linking the mortality database to the national surveillance data set and the Scottish Morbidity Record. We used a self-controlled case series (SCCS) design to evaluate the relative incidence of deaths with respiratory/circulatory deaths in the first year after an RSV episode. We defined the risk interval as the first year after the RSV episode, and the control interval as the period before and after the risk interval until 5 years after birth. Age-adjusted incidence ratio and attributable fraction were generated using the R software package SCCS.

Results

We included 162 respiratory/circulatory deaths, of which 36 occurred in children with a history of laboratory-confirmed RSV infection. We found that the mortality risk decreased with time after the RSV episode and that the risk was statistically significant for the month after RSV illness. More than 90% of respiratory/circulatory deaths occurring within 1 week after the RSV episode were attributable to RSV (attributable fraction, 93.9%; 95% confidence interval, 77.6%–98.4%), compared with about 80% of those occurring 1 week to 1 month after RSV illness (80.3%; 28.5%–94.6%).

Conclusions

We found an increased risk of death in the first month after an RSV illness episode leading to healthcare attendance. This provides a practical cutoff time window for community-based surveillance studies estimating RSV-related mortality risk. Further studies are warranted to assess the mortality risk beyond the first month after RSV illness episode.
Metabolomic Signature as a Predictor of Liver Disease Events in Patients With HIV/HCV Coinfection
Authors: Naggie Susanna , Lusk Sam , Thompson J Will , Mock Meredith , Moylan Cynthia , Lucas Joseph E , Dubois Laura , St John-Williams Lisa , Moseley M Arthur , Patel Keyur
Published: June 2020

Background

Advanced liver disease due to hepatitis C virus (HCV) is a leading cause of human immunodeficiency virus (HIV)-related morbidity and mortality. There remains a need to develop noninvasive predictors of clinical outcomes in persons with HIV/HCV coinfection.

Methods

We conducted a nested case-control study in 126 patients with HIV/HCV and utilized multiple quantitative metabolomic assays to identify a prognostic profile that predicts end-stage liver disease (ESLD) events including ascites, hepatic encephalopathy, hepatocellular carcinoma, esophageal variceal bleed, and spontaneous bacterial peritonitis. Each analyte class was included in predictive modeling, and area under the receiver operator characteristic curves (AUC) and accuracy were determined.

Results

The baseline model including demographic and clinical data had an AUC of 0.79. Three models (baseline plus amino acids, lipid metabolites, or all combined metabolites) had very good accuracy (AUC, 0.84–0.89) in differentiating patients at risk of developing an ESLD complication up to 2 years in advance. The all combined metabolites model had sensitivity 0.70, specificity 0.85, positive likelihood ratio 4.78, and negative likelihood ratio 0.35.

Conclusions

We report that quantification of a novel set of metabolites may allow earlier identification of patients with HIV/HCV who have the greatest risk of developing ESLD clinical events.
Regrounding Critical Theory: Lenin on Imperialism, Nationalism, and Strategy
Authors: Pahnke Anthony
Published: June 2020

We live at a time of heightened nationalism on the political right and left, from the mobilization of anti-immigrant sentiment in the United States and Europe, to promoting Palestinian liberation. This article, focusing on Lenin's work concerning imperialism, shows the importance, yet shortcomings of foregrounding the nation in calling for social transformation. The piece reads Lenin's contributions on imperialism, highlighting his understanding of strategy and the dual nature of nationalism, in light of debates within Critical Theory more generally. As I argue, Lenin offers insights for Critical Theorists, particularly on the place of nationalism within transformative political projects, as well as on the dynamics of capitalist accumulation and territorial acquisition. Lenin's work on imperialism draws our attention to the idea that only by mobilizing beyond the state/society binary—which many Critical Theorists and activists reify, sometimes unintentionally—can we explore the nature of emancipatory political action.
Macronutrient composition, true metabolizable energy and amino acid digestibility, and indispensable amino acid scoring of pulse ingredients for use in canine and feline diets
Authors: Reilly Lauren M , von Schaumburg Patrick C , Hoke Jolene M , Davenport Gary M , Utterback Pamela L , Parsons Carl M , de Godoy Maria R C
Published: June 2020

The rising consumer demand for alternative and sustainable protein sources drives the popularity of the use of plant-based proteins in the pet food industry. Pulse crops, which include beans, peas, lentils, and chickpeas, have become an important addition to both human and animal diets due to their protein content and functional properties. However, knowledge of their nutrient composition and protein quality is necessary for the proper formulation of these ingredients in pet foods. The objective of this study was to determine the macronutrient composition and standardized amino acid digestibility and to describe the protein quality through the use of digestible indispensable amino acid scores (DIAAS-like) of five pulse ingredients. Black bean (BB) grits, garbanzo beans (GB), green lentils (GL), navy bean (NB) powder, and yellow peas (YP) were analyzed for dry matter (DM), ash and organic matter (OM), crude protein (CP), gross energy (GE), acid hydrolyzed fat (AHF), and total dietary fiber (TDF) to determine the macronutrient composition. Precision-fed rooster assays were conducted using cecectomized roosters to calculate standardized amino acid digestibility and true metabolizable energy corrected for nitrogen (TMEn). The essential amino acids, with the exception of methionine, were highly digestible with digestibility values of 80% to 90% (dry matter basis) for all selected pulse ingredients. BB grits had the lowest (P < 0.05) digestibility of arginine (86.5%) and histidine (80.6%) in contrast to GB (94.9% and 89.9%, respectively). The TMEn of GB was highest (P < 0.05) at 3.56 kcal/g compared with the other pulses. The DIAAS-like values for adult dogs were consistently the lowest for methionine for all pulses, making it the first-limiting amino acid in these ingredients. The DIAAS-like values for adult cats showed GL had lowest (P < 0.05) score in tryptophan compared with other pulses when using both AAFCO values and NRC recommended allowances as reference proteins. Methionine was the first-limiting amino acid for YP and tryptophan for GL. Based on macronutrient composition, protein quality, and amino acid digestibility, it can be concluded that pulse ingredients have the required nutritional characteristics to be viable protein sources in canine and feline foods. However, the use of complementary protein sources is recommended to counterbalance any potential limiting amino acids in pulse ingredients.
Quantification of 54 Benzodiazepines and Z-Drugs, Including 20 Designer Ones, in Plasma
Authors: Degreef Maarten , Vits Lore , Berry Eleanor M , Maudens Kristof E K , van Nuijs Alexander L N
Published: June 2020

Benzodiazepines are widely used in the treatment of sleep and anxiety disorders, as well as epileptic seizures and alcohol withdrawal because of their broad therapeutic index and low cost. Due to their central nervous system depressant effects they are also often implicated in traffic accidents and drug-related intoxications. With an increasing number of designer benzodiazepines used in a recreational setting, there is a need for analytical methods to be able to quantify both the prescribed and designer benzodiazepines. A liquid chromatography–triple quadrupole mass spectrometry method was developed for the quantification of 34 prescribed and 20 designer benzodiazepines in plasma. Different sample preparation strategies, including protein precipitation, liquid–liquid extraction, solid-phase extraction and mini-QuEChERS, were tested. The best recoveries for all compounds of interest were obtained with a liquid–liquid extraction using methyl-tertiary-butyl-ether and 500 μL plasma. The method was fully validated according to the European Medicines Agency guidelines for all compounds, except pivoxazepam, which is included for qualitative purposes only. In-sample stability issues were observed for cloxazolam, both at ambient temperature and during long-term storage at −20°C. Due to the large number of compounds included, the simple and time-efficient sample preparation and the relatively inexpensive instrumentation used, the presented method can be readily implemented in both therapeutic drug monitoring and forensic analyses.
The Global Burn Registry: A Work in Progress
Authors: Gibson Cameron , Bessey Palmer Q , Gallagher James J
Published: June 2020

In 2018, the World Health Organization (WHO) launched the Global Burn Registry (GBR). Its purpose is to help improve the understanding of burn injury worldwide. The purpose of this study was to identify early findings from this database. The GBR was accessed on January 5, 2020. Cases from centers in low income (LIC) and low-middle-income countries (LMIC) were combined into a low resource (LR) group, and cases in high income (HIC) and upper-middle-income countries (UMIC) were combined into a high resource (HR) group. Statistical analysis was performed with SAS 9.4. Data are expressed as mean ± SEM. Logistic regression was used to identify risk factors for death. Revised Baux Score (RBS) was calculated. Odds ratios are expressed as mean (95% confidence interval). The LA50 was calculated from the regression of death and total burn size (TBSA) for different age groups. At the time of analysis, there were 4307 cases in the GBR treated at 28 facilities in 17 countries (5 HIC, 5 UMIC, 4 LMIC, and 3 LIC). There were 2945 cases (68%) from HR countries and 1362 (32%) from LR countries. The mean age of patients in both LR and HR was similar (24.5 ± 0.5 vs 24.2 ± 0.4 years, P = .58), but LR had larger TBSA burns (30.5 ± 0.7% vs 19.8 ± 0.4% TBSA, P < .0001). There were fewer scald burns and more flame injuries in the LR countries (28.4 ± 1.3% vs 43.3 ± 1.0% and 55.2 ± 1.4% vs 39.0 ± 0.9%, P < .0001). Case fatality and RBS were greater in LR (31.9 ± 1.3% vs 9.4 ± 0.5% and 59.4 ± 1.1% vs 45.3 ± 0.6%, P < .0001). In regression analysis, LR was an independent risk factor for death with an odds ratio of 4.2 (3.2–5.4). The LA50 for HR countries was similar to that calculated from cases in the National Burn Repository of the American Burn Association (ABA NBR). For LR countries, the LA50 was lower for all ages except those 65 and older, ranging from 30% to 43% TBSA. Only a few facilities have contributed data to the GBR so far, with LR countries less represented than HR ones. The proportion of cases in the pediatric age group is much less represented in LR countries than in HR, possibly because many burned children in LR countries do not get burn care at specialized centers. Survival in HR countries is similar to that in North America. The GBR provides early insights into global burn care. Opportunities for improvement are greatest in LR countries. New Innovations may be necessary to increase participation from burn centers in LR countries. This report provides an early look at burn care across the globe based on cases in the GBR. It may inform further efforts to characterize and improve burn care in LR countries.