bluuebunny/crossref_metadata_2025 huggingface dataset:
What Do We Know about Social and Non-Social Factors Influencing the Pathway from Cognitive Health to Dementia? A Systematic Review of Reviews
Authors: Lenart-Bugla Marta , Łuc Mateusz , Pawłowski Marcin , Szcześniak Dorota , Seifert Imke , Wiegelmann Henrik , Gerhardus Ansgar , Wolf-Ostermann Karin , Rouwette Etiënne A. J. A. , Ikram M. Arfan , Brodaty Henry , Jeon Yun-Hee , Maddock Jane , Marseglia Anna , Melis René J. F. , Samtani Suraj , Wang Hui-Xin , Welmer Anna-Karin , Vernooij-Dassen Myrra , Rymaszewska Joanna
Published: September 2022

The heterogeneous and multi-factorial nature of dementia requires the consideration of all health aspects when predicting the risk of its development and planning strategies for its prevention. This systematic review of reviews provides a comprehensive synthesis of those factors associated with cognition in the context of dementia, identifying the role of social aspects and evidencing knowledge gaps in this area of research. Systematic reviews and meta-analyses from 2009–2021 were searched for within Medline, PsycINFO, CINAHL Complete, Cochrane, and Epistemonikos. Reviewers independently screened, reviewed, and assessed the records, following the PRISMA-2020 guidelines. From 314 included studies, 624 cognitive-related factors were identified, most of them risk factors (61.2%), mainly belonging to the group of ‘somatic comorbidities’ (cardiovascular disease and diabetes) and ‘genetic predispositions’. The protective factors (20%) were mainly related to lifestyle, pointing to the Mediterranean diet, regular physical activity, and cognitively stimulating activities. Social factors constituted 9.6% of all identified factors. Research on biological and medical factors dominates the reviewed literature. Greater social support and frequent contact may confer some protection against cognitive decline and dementia by delaying its onset or reducing the overall risk; however, overall, our findings are inconsistent. Further research is needed in the fields of lifestyle, psychology, social health, and the protective factors against cognitive decline and dementia.
Estimating Space-Cooling Energy Consumption and Indoor PM2.5 Exposure across Hong Kong Using a City-Representative Housing Stock Model
Authors: Zhong Xuyang , Zhang Zhiang , Wu Wei , Zhang Ruijun
Published: September 2022

High-quality data on building energy use and indoor pollution are critical to supporting government efforts to reduce carbon emissions and improve the population’s health. This study describes the development of a city-representative housing stock model used for estimating space-cooling energy use and indoor PM2.5 exposure across the Hong Kong housing stock. Archetypes representative of Hong Kong dwellings were developed based on geographically-referenced housing databases. Simulations of unique combinations of archetype, occupation, and environment were run using EnergyPlus, estimating the annual space-cooling energy consumption and annual average PM2.5 exposure concentrations under both non-retrofit and retrofit scenarios. Results show that modern village houses and top-floor flats in high-rise residential buildings, on average, used 19% more space-cooling energy than other archetypes. Dwellings in urban areas had lower exposure to outdoor-sourced PM2.5 and higher exposure to indoor-sourced PM2.5 compared to those in rural areas. The percentage decrease in space-cooling energy consumption caused by energy efficiency retrofits, including external wall insulation, low-e windows, and airtightening, varied significantly based on archetype. The implementation of external wall insulation in the housing stock led to an average decrease of 3.5% in indoor PM2.5 exposure, whilst airtightening and low-e windows resulted in 7.9% and 0.2% average increases in exposure, respectively.
White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy
Authors: Dahl Edgar , Villwock Sophia , Habenberger Peter , Choidas Axel , Rose Michael , Klebl Bert M.
Published: September 2022

The aim of our proposed concept is to find new target structures for combating cancers with unmet medical needs. This, unfortunately, still applies to the majority of the clinically most relevant tumor entities such as, for example, liver cancer, pancreatic cancer, and many others. Current target structures almost all belong to the class of oncogenic proteins caused by tumor-specific genetic alterations, such as activating mutations, gene fusions, or gene amplifications, often referred to as cancer “driver alterations” or just “drivers.” However, restoring the lost function of tumor suppressor genes (TSGs) could also be a valid approach to treating cancer. TSG-derived proteins are usually considered as control systems of cells against oncogenic properties; thus, they represent the brakes in the “car-of-life.” Restoring these tumor-defective brakes by gene therapy has not been successful so far, with a few exceptions. It can be assumed that most TSGs are not being inactivated by genetic alteration (class 1 TSGs) but rather by epigenetic silencing (class 2 TSGs or short “C2TSGs”). Reactivation of C2TSGs in cancer therapy is being addressed by the use of DNA demethylating agents and histone deacetylase inhibitors which act on the whole cancer cell genome. These epigenetic therapies have neither been particularly successful, probably because they are “shotgun” approaches that, although acting on C2TSGs, may also reactivate epigenetically silenced oncogenic sequences in the genome. Thus, new strategies are needed to exploit the therapeutic potential of C2TSGs, which have also been named DNA methylation cancer driver genes or “DNAme drivers” recently. Here we present a concept for a new translational and therapeutic approach that focuses on the phenotypic imitation (“mimesis”) of proteins encoded by highly disease-relevant C2TSGs/DNAme drivers. Molecular knowledge on C2TSGs is used in two complementary approaches having the translational concept of defining mimetic drugs in common: First, a concept is presented how truncated and/or genetically engineered C2TSG proteins, consisting solely of domains with defined tumor suppressive function can be developed as biologicals. Second, a method is described for identifying small molecules that can mimic the effect of the C2TSG protein lost in the cancer cell. Both approaches should open up a new, previously untapped discovery space for anticancer drugs.
Ischemic Stroke Disrupts Sleep Homeostasis in Middle-Aged Mice
Authors: Sharma Rishi , Chischolm Abigail , Parikh Meet , Qureshi Adnan I. , Sahota Pradeep , Thakkar Mahesh M.
Published: September 2022

Sleep disturbances, including insomnia and excessive daytime sleepiness, are highly prevalent in patients with ischemic stroke (IS), which severely impacts recovery and rehabilitation efforts. However, how IS induces sleep disturbances is unclear. Three experiments were performed on middle-aged C57BL/6J mice, instrumented with sleep recording electrodes and/or subjected to 1 h of middle cerebral artery (MCAO; Stroke group) or sham (Sham group) occlusion to induce IS. After 48 h of reperfusion (a) experiment 1 verified sensorimotor deficit (using Garcia scale) and infarction (using TTC staining) in this mouse model; (b) experiment 2 examined the effects of IS on the quality (sleep latency and NREM delta power) and quantity (duration) of sleep; and (c) experiment 3 determined the effects of IS on sleep homeostasis using sleep deprivation (SD) and recovery sleep (RS) paradigm. Stroke mice display (a) a significant correlation between sensorimotor deficit and cerebral infarction; (b) insomnia-like symptoms (increased sleep latency, reduced NREM duration and delta power) during the light (inactive) period and daytime sleepiness-like symptoms during the dark (active) period mimicking sleep in IS patients; and (c) impairments in the markers of sleep pressure (during SD) and sleep dissipation (during RS). Our results suggest that IS disrupts sleep homeostasis to cause sleep disturbances.
Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes
Authors: Wang Joshua J. , Park Karen Sophia , Dhimal Narayan , Shen Shichen , Tang Xixiang , Qu Jun , Zhang Sarah X.
Published: September 2022

The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium signaling, bioenergetics, and inflammation. Disturbances in these processes and dysregulation of the ER and mitochondrial homeostasis contribute to the pathogenesis of diabetic retinopathy (DR). However, few studies have examined the impact of diabetes on the retinal MAM and its implication in DR pathogenesis. In the present study, we investigated the proteomic changes in retinal MAM from Long Evans rats with streptozotocin-induced long-term Type 1 diabetes. Furthermore, we performed in-depth bioinformatic analysis to identify key MAM proteins and pathways that are potentially implicated in retinal inflammation, angiogenesis, and neurodegeneration. A total of 2664 unique proteins were quantified using IonStar proteomics-pipeline in rat retinal MAM, among which 179 proteins showed significant changes in diabetes. Functional annotation revealed that the 179 proteins are involved in important biological processes such as cell survival, inflammatory response, and cellular maintenance, as well as multiple disease-relevant signaling pathways, e.g., integrin signaling, leukocyte extravasation, PPAR, PTEN, and RhoGDI signaling. Our study provides comprehensive information on MAM protein changes in diabetic retinas, which is helpful for understanding the mechanisms of metabolic dysfunction and retinal cell injury in DR.
Prognostic Impact of Low-Level p53 Expression on Brain Astrocytomas Immunopositive for Epidermal Growth Factor Receptor
Authors: Tsai Hung-Pei , Lin Chien-Ju , Wu Chieh-Hsin , Chen Yi-Ting , Lu Ying-Yi , Kwan Aij-Lie , Lieu Ann-Shung
Published: September 2022

Although the expression of p53 and epidermal growth factor receptor (EGFR) is associated with therapeutic resistance and patient outcomes in many malignancies, the relationship in astrocytomas is unclear. This study aims to correlate p53 and EGFR expression in brain astrocytomas with overall patient survival. Eighty-two patients with astrocytomas were enrolled in the study. Semi-quantitative p53 and EGFR immunohistochemical staining was measured in tumor specimens. The mean follow-up after astrocytoma surgery was 18.46 months. The overall survival rate was 83%. Survival was reduced in EGFR-positive patients compared with survival in EGFR-negative patients (p < 0.05). However, no significant differences in survival were detected between patients with high and low p53 expression. In patients with low p53 expression, positive EGFR staining was associated with significantly worse survival compared with patients with negative EGFR staining (log-rank test: p < 0.001). Survival rates in positive and negative EGFR groups with high p53 protein expression were similar (log-rank test: p = 0.919). The IC50 of an EGFR inhibitor was higher in GBM cells with high p53 protein expression compared with the IC50 in cells with low p53 expression. Combined EGFR and p53 expression may have prognostic significance in astrocytomas.
Effects of the IR Drop on the Electrochemical Corrosion of X80 Pipeline Steel in Different Solutions
Authors: Bai Yunlong , Xu Jin , Wei Boxin , Sun Cheng
Published: September 2022

Polarization curves are popularly used in many investigations; however, some wrong results are obtained when inexperienced researchers do not deeply understand electrochemical processes. In this study, the effects of the IR drop (Deviation due to I (current) and R (resistance)) and scanning direction on polarization curves were investigated. Three different test methods were used to test the polarization curve of X80 pipeline steel in five kinds of solutions. The different scanning directions led to differences in the cathodic polarization curves. In addition, the effect of IR drop on the Tafel curve in acidic solutions is significantly greater than in neutral and alkaline solutions. There is a large effect of the IR drop on shapes and fitting results of polarization curves in acidic solutions, and the IR drop must be considered for the fitting of curves. Scanning direction has an influence on the shape of polarization curves when a layer of corrosion products is formed on the steel surface, and a novel two-electrode coupon was introduced to solve this problem.
Bearing Fault Diagnosis Based on Measured Data Online Processing, Domain Fusion, and ANFIS
Authors: Tran Quang Thinh , Nguyen Sy Dzung
Published: September 2022

Processing noise online in sensors-based measurement data (SMD) and mitigating the effect of domain drift are always challenges. As a result, it negatively impacts the effectiveness and feasibility of data-driven model (DDM)-based mechanical-system fault identification (MFI). Here, we propose an online bearing fault diagnosis method named ANFIS-BFDM by using an adaptive neurofuzzy inference system (ANFIS). Reduction in the influence of domain drift between the source domain and target domain (DDSTD) is considered in both the data processing and fault identification. Online solutions for preprocessing SMD and exploiting the filtered data to label the target domain are presented in a fusion domain deriving from the source and target domains. First, in the offline phase, frequency-based splitting of SMD into different time series is performed to cancel the high-frequency region. An optimal data screening threshold (ODST) is distilled in the remaining low-frequency data to develop an impulse noise filter named FIN. An ANFIS then identifies the dynamic response of the bearing(s) via the filtered data. The FIN and ANFIS are finally exploited during the online phase to filter noise and recognize the object’s health status online. The survey results reflect the positive effects of the method, even if severe impulse noise appears in the databases.
Nonlinear Excitations in Ultracold Atoms Trapped in Triple Optical Lattices
Authors: Basu Pradosh , Halder Barun , Raghav Sriganapathy , Roy Utpal
Published: September 2022

Various solitary wave excitations are found for a Bose-Einstein condensate in presence of two hybrid potentials in the form of triple mixtures of optical lattices. One of these potentials comprises of a combination of two important lattice profiles, such as frustrated optical lattice and double-well super-lattice, within one. Another represents a composite lattice combination, resulting in a wider and deeper frustrated optical lattice. The dynamical equation for such a system is solved by the exact analytical method to obtain a bright solitary wave, periodic wave and cnoidal wave excitations. We also report Anderson localization, bifurcation of condensate at the center and a competition between two different types of localizations upon trap engineering. Dynamical and structural stability analyses are also carried out, which reveal the obtained solutions as extremely stable for structural noise incorporation and sufficiently stable for dynamical stability. These triple mixtures of optical lattices impart better tunability on the condensate profile, which has made this system a true quantum simulator.
Synthesis and Characterization of Mechanically Alloyed Nanostructured (Ti,Cr)C Carbide for Cutting Tools Application
Authors: Mhadhbi Mohsen , Polkowski Wojciech
Published: September 2022

(Ti,Cr)C is a novel additive for high-performance cermets. In this work, a (Ti0.8Cr0.2)C nanostructured solid solution was synthesized via Mechanical Alloying (MA) from the mixture of of Ti, Cr, and C powders. The MA process was carried out at room temperature under argon atmosphere with a duration limited to 20 h. Phase changes and microstructure evolution of the powders during the MA process were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques. The results of XRD analysis demonstrated the synthesis of (Ti,Cr)C solid solution with a crystallite size of about 10 nm that were micro-strained to about 1.34%. The crystallite size displays a decreasing trend with increasing milling time. The results of direct observations of structural features by TEM method in 20 h MAed samples shows a good agreement with the results from the XRD analyses.
Semantic Segmentation of Maxillary Teeth and Palatal Rugae in Two-Dimensional Images
Authors: El Bsat Abdul Rehman , Shammas Elie , Asmar Daniel , Sakr George E. , Zeno Kinan G. , Macari Anthony T. , Ghafari Joseph G.
Published: September 2022

The superimposition of sequential radiographs of the head is commonly used to determine the amount and direction of orthodontic tooth movement. A harmless method includes the timely unlimited superimposition on the relatively stable palatal rugae, but the method is performed manually and, if automated, relies on the best fit of surfaces, not only rugal structures. In the first step, motion estimation requires segmenting and detecting the location of teeth and rugae at any time during the orthodontic intervention. Aim: to develop a process of tooth segmentation that eliminates all manual steps to achieve an autonomous system of assessment of the dentition. Methods: A dataset of 797 occlusal views from photographs of teeth was created. The photographs were manually semantically segmented and labeled. Machine learning methods were applied to identify a robust deep network architecture able to semantically segment teeth in unseen photographs. Using well-defined metrics such as accuracy, precision, and the average mean intersection over union (mIoU), four network architectures were tested: MobileUnet, AdapNet, DenseNet, and SegNet. The robustness of the trained network was additionally tested on a set of 47 image pairs of patients before and after orthodontic treatment. Results: SegNet was the most accurate network, producing 95.19% accuracy and an average mIoU value of 86.66% for the main sample and 86.2% for pre- and post-treatment images. Conclusions: Four architectural tests were developed for automated individual teeth segmentation and detection in two-dimensional photos that required no post-processing. Accuracy and robustness were best achieved with SegNet. Further research should focus on clinical applications and 3D system development.
Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography
Authors: Rampidis Georgios , Rafailidis Vasileios , Kouskouras Konstantinos , Davidhi Andjoli , Papachristodoulou Angeliki , Samaras Athanasios , Giannakoulas George , Ziakas Antonios , Prassopoulos Panagiotis , Karvounis Haralambos
Published: September 2022

Coronary artery disease (CAD) represents a modern pandemic associated with significant morbidity and mortality. The multi-faceted pathogenesis of this entity has long been investigated, highlighting the contribution of systemic factors such as hyperlipidemia and hypertension. Nevertheless, recent research has drawn attention to the importance of geometrical features of coronary vasculature on the complexity and vulnerability of coronary atherosclerosis. Various parameters have been investigated so far, including vessel-length, coronary artery volume index, cross-sectional area, curvature, and tortuosity, using primarily invasive coronary angiography (ICA) and recently non-invasive cardiac computed tomography angiography (CCTA). It is clear that there is correlation between geometrical parameters and both the haemodynamic alterations augmenting the atherosclerosis-prone environment and the extent of plaque burden. The purpose of this review is to discuss the currently available literature regarding this issue and propose a potential non-invasive imaging biomarker, the geometric risk score, which could be of importance to allow the early detection of individuals at increased risk of developing CAD.
Advanced Imaging in Multiple Myeloma: New Frontiers for MRI
Authors: Torkian Pooya , Azadbakht Javid , Andrea Bonaffini Pietro , Amini Behrang , Chalian Majid
Published: September 2022

Plasma cell dyscrasias are estimated to newly affect almost 40,000 people in 2022. They fall on a spectrum of diseases ranging from relatively benign to malignant, the malignant end of the spectrum being multiple myeloma (MM). The International Myeloma Working Group (IMWG) has traditionally outlined the diagnostic criteria and therapeutic management of MM. In the last two decades, novel imaging techniques have been employed for MM to provide more information that can guide not only diagnosis and staging, but also treatment efficacy. These imaging techniques, due to their low invasiveness and high reliability, have gained significant clinical attention and have already changed the clinical practice. The development of functional MRI sequences such as diffusion weighted imaging (DWI) or intravoxel incoherent motion (IVIM) has made the functional assessment of lesions feasible. Moreover, the growing availability of positron emission tomography (PET)–magnetic resonance imaging (MRI) scanners is leading to the potential combination of sensitive anatomical and functional information in a single step. This paper provides an organized framework for evaluating the benefits and challenges of novel and more functional imaging techniques used for the management of patients with plasma cell dyscrasias, notably MM.
The Supratrochlear Artery Sign—A New Piece in the Puzzle of Cerebral Vasospasm
Authors: Richter Cindy , Werdehausen Robert , Jentzsch Jennifer , Lindner Dirk , Gerhards Thilo , Hantel Torsten , Gaber Khaled , Schob Stefan , Saur Dorothee , Quäschling Ulf , Hoffmann Karl-Titus , Ziganshyna Svitlana , Halama Dirk
Published: September 2022

Background: Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) has been extensively investigated, but the impact of collateralization remains unclear. We investigated the predictive value of collateral activation for delayed cerebral ischemia (DCI)-related infarctions and functional outcome. Methods: Data from 43 patients with CVS (January 2014 to August 2021) were evaluated for the angiographic presence of leptomeningeal and ophthalmic collaterals (anterior falcine artery (AFA), supratrochlear artery (STA), dorsal nasal artery (DNA)) on internal carotid artery angiograms. Vasospasm-related infarction and the modified Rankin Scale (mRS) score after six months were chosen as the endpoints. Results: 77% of the patients suffered from DCI-related infarctions. In 233 angiograms (at hospitalization, before spasmolysis, after six months), positive vessel signs were observed in 31 patients for STA, 35 for DNA, and 31 for AFA. The STA sign had the highest positive (84.6%) and negative (85.7%) predictive value for unfavorable outcome (mRS 4–6) in patients aged ≥50 years. DNA and AFA signs were not meaningful predictors for either endpoint. Leptomeningeal collaterals showed a positive Pearson’s correlation with the STA sign in 87.5% (p = 0.038) without providing any prediction for either endpoint. Conclusions: The STA sign is associated with clinical outcome in patients with CVS after SAH aged ≥50 years, and was correlated with the occurrence of leptomeningeal collaterals.
Differentiating Enchondromas and Atypical Cartilaginous Tumors in Long Bones with Computed Tomography and Magnetic Resonance Imaging
Authors: Gassert Felix G. , Breden Sebastian , Neumann Jan , Gassert Florian T. , Bollwein Christine , Knebel Carolin , Lenze Ulrich , von Eisenhart-Rothe Rüdiger , Mogler Carolin , Makowski Marcus R. , Peeken Jan C. , Wörtler Klaus , Gersing Alexandra S.
Published: September 2022

The differentiation between the atypical cartilaginous tumor (ACT) and the enchondromas is crucial as ACTs require a curettage and clinical as well as imaging follow-ups, whereas in the majority of cases enchondromas require neither a treatment nor follow-ups. Differentiating enchondromas from ACTs radiologically remains challenging. Therefore, this study evaluated imaging criteria in a combination of computed tomography (CT) and magnetic resonance (MR) imaging for the differentiation between enchondromas and ACTs in long bones. A total of 82 patients who presented consecutively at our institution with either an ACT (23, age 52.7 ±18.8 years; 14 women) or an enchondroma (59, age 46.0 ± 11.1 years; 37 women) over a period of 10 years, who had undergone preoperative MR and CT imaging and subsequent biopsy or/and surgical removal, were included in this study. A histopathological diagnosis was available in all cases. Two experienced radiologists evaluated several imaging criteria on CT and MR images. Likelihood of an ACT was significantly increased if either edema within the bone (p = 0.049), within the adjacent soft tissue (p = 0.006) or continuous growth pattern (p = 0.077) were present or if the fat entrapment (p = 0.027) was absent on MR images. Analyzing imaging features on CT, the likelihood of the diagnosis of an ACT was significantly increased if endosteal scalloping >2/3 (p < 0.001), cortical penetration (p < 0.001) and expansion of bone (p = 0.002) were present and if matrix calcifications were observed in less than 1/3 of the tumor (p = 0.013). All other imaging criteria evaluated showed no significant influence on likelihood of ACT or enchondroma (p > 0.05). In conclusion, both CT and MR imaging show suggestive signs which can help to adequately differentiate enchondromas from ACTs in long bones and therefore can improve diagnostics and consequently patient management. Nevertheless, these features are rare and a combination of CT and MR imaging features did not improve the diagnostic performance substantially.
Oral Health Status and Multiple Sclerosis: Classic and Non-Classic Manifestations—Case Report
Authors: Costa Céu , Santiago Hugo , Pereira Sofia , Castro Ana Rita , Soares Sandra Clara
Published: September 2022

Background: Multiple sclerosis is an autoimmune disease of the central nervous system with neurological and motor symptoms that affect the orofacial region. The aim of this work is to present a patient that lacks the three classic orofacial manifestations but has other less common clinical alterations. Case presentation: A 49-year-old female patient diagnosed with long-term relapsing–remitting multiple sclerosis visited the dentist complaining of mild but persistent orofacial pain including the temporomandibular joint and pain not specific to any tooth. She presented mucosal irritation, xerostomia, halitosis, and localized gingivitis. There was excessive wear of the upper and lower incisal edges and the occlusal faces of the upper canines and loss of six teeth due to caries. After a clinical oral examination, the diagnosis was temporomandibular joint disorder, gingivitis, dental hypersensitivity, bruxism, hyposalivation, xerostomia, and halitosis. Conclusions: Patients with multiple sclerosis present classic orofacial manifestations. Although these were not observed in this patient, she had others, such as gingivitis, tooth hypersensitivity, and bruxism. In addition, despite few studies associating a higher prevalence of caries with these patients, the number of carious and missing teeth in this patient highlight the evidence that multiple sclerosis has had a significant impact on the patient’s dental status over the years.
Analysis of Osteoclasts and Root Resorption in Corticotomy-Facilitated Orthodontics with Ibuprofen Administration—An Animal Study
Authors: Jindarojanakul Chanakant , Chanmanee Pannapat , Samruajbenjakun Bancha
Published: September 2022

Following corticotomy surgery, patients experience moderate to severe post-operative pain that necessitates prescriptions of analgesics. The prostaglandin inhibitory effect of ibuprofen influences the mobility of teeth during orthodontic treatment. This study aimed to determine how ibuprofen affects histological reactions and dental root resorption during orthodontic tooth movement aided by corticotomy. Forty-two male Wistar rats were divided into three groups by random selection: (1) control group, (2) corticotomy group (CO), and (3) corticotomy with 0.6 mL of 15 mg/kg ibuprofen group (CI). On each buccal and palatal alveolar bone, two decortication points were made. Orthodontic tooth movement was induced on the maxillary first molar for 21 days utilizing a NiTi-closed coil spring with 10 g of force. Hematoxylin and eosin were used to prepare and stain the histological sections. The numbers of osteoclasts on days 0, 7, 14, and 21 were determined, and the root resorption area on days 0 and 21 was measured. Compared to the control group, the osteoclast counts in the CO and CI groups were considerably greater (p < 0.002). No significant differences were observed between the CO and CI groups in the numbers of osteoclasts or the percentages of root resorption (p > 0.05). The amounts of osteoclast activity and root resorption were unaffected by the administration of ibuprofen in corticotomy-facilitated tooth movement.
A Novel Hyperchaotic 2D-SFCF with Simple Structure and Its Application in Image Encryption
Authors: Hu Yongsheng , Wu Han , Zhou Luoyu
Published: September 2022

In this paper, a novel image encryption algorithm is proposed based on hyperchaotic two-dimensional sin-fractional-cos-fractional (2D-SFCF), called sin-fractional-cos-fractional image-encryption (SFCF-IE). The 2D-SFCF is constructed from two one-dimensional cosine fractional (1-DCFs), and it has a more complex chaotic behavior with a larger parameter space than one-dimensional chaotic systems. Compared with the two-dimensional (2D) chaotic system, the 2D-SFCF has a simple structure, and the parameter space in the chaotic state is continuous, which is beneficial to generating the keystream in the cryptosystem. Therefore, in the novel image encryption algorithm, we use the 2D-SFCF to generate the keystream of the cryptosystem. The encryption algorithm is a process of scrambling and diffusion. Different from common diffusion methods, the diffusion starting position of the SFCF-IE is randomly generated, enhancing the algorithm’s security. Simulation experiments show that the image encrypted by this algorithm has better distribution characteristics and can resist common attack methods.
Nighttime Image Stitching Method Based on Guided Filtering Enhancement
Authors: Yan Mengying , Qin Danyang , Zhang Gengxin , Zheng Ping , Bai Jianan , Ma Lin
Published: September 2022

Image stitching refers to stitching two or more images with overlapping areas through feature points matching to generate a panoramic image, which plays an important role in geological survey, military reconnaissance, and other fields. At present, the existing image stitching technologies mostly adopt images with good lighting conditions, but the lack of feature points in scenes with weak light such as morning or night will affect the image stitching effect, making it difficult to meet the needs of practical applications. When there exist concentrated areas of brightness such as lights and large dark areas in the nighttime image, it will further cause the loss of image details making the feature point matching unavailable. The obtained perspective transformation matrix cannot reflect the mapping relationship of the entire image, resulting in poor splicing effect, and it is difficult to meet the actual application requirements. Therefore, an adaptive image enhancement algorithm is proposed based on guided filtering to preprocess the nighttime image, and use the enhanced image for feature registration. The experimental results show that the image obtained by preprocessing the nighttime image with the proposed enhancement algorithm has better detail performance and color restoration, and greatly improves the image quality. By performing feature registration on the enhanced image, the number of matching logarithms of the image increases, so as to achieve high accuracy for images stitching.
Interpretation of Quantum Theory: The Quantum “Grue-Bleen” Problem
Authors: Schumacher Benjamin , Westmoreland Michael D.
Published: September 2022

We present a critique of the many-world interpretation of quantum mechanics, based on different “pictures” that describe the time evolution of an isolated quantum system. Without an externally imposed frame to restrict these possible pictures, the theory cannot yield non-trivial interpretational statements. This is analogous to Goodman’s famous “grue-bleen” problem of language and induction. Using a general framework applicable to many kinds of dynamical theories, we try to identify the kind of additional structure (if any) required for the meaningful interpretation of a theory. We find that the “grue-bleen” problem is not restricted to quantum mechanics, but also affects other theories including classical Hamiltonian mechanics. For all such theories, absent external frame information, an isolated system has no interpretation.
An X-Band Reflective Active Polarization Conversion Metasurface
Authors: Sui Ran , Wang Junjie , Xu Yong , Feng Dejun
Published: September 2022

In this paper, an active polarization conversion metasurface (APCM) operating in the X-band (8–12 GHz) is presented. Active unit cells consist of three metal layers and two substrate layers. Anisotropic metal patches, positive-intrinsic-negative (PIN) diodes, and bias lines are integrated into the surface layer to form a chiral structure. A simple and efficient polarization conversion function is realized in this designed structure. The operating mode is switched between linear-to-linear (LTL) polarization conversion and linear-to-circular (LTC) polarization conversion by switching the loaded PIN diode. In the LTL polarization conversion state, the polarization conversion ratio of APCM is over 90% in X-band. Reflected wave circular polarization axis ratio <3 dB in 8–12 GHz when in LTC state. The proposed structure is verified by experimental measurements.
Analysis and CFD Modeling of Thermal Collectors with a Tracker System
Authors: Rimar Miroslav , Fedak Marcel , Kulikov Andrii , Kulikova Olha , Lopusniak Martin
Published: September 2022

Thermal solar systems are currently one of the most suitable ways to convert solar radiation into usable energy. To ensure maximum energy gain, it is necessary to correctly adjust the direction of the collectors in the southern direction. The deviation from the south is energy acceptable, but there are losses that reduce the overall efficiency of the system. A suitable tool for increasing the efficiency of solar thermal collectors is the usage of tracker systems which track the position of the Sun along the ecliptic orbit. The system is directed south towards the equator. It is important to know the effectiveness of the system in terms of assessment. For the monitored period of the equinox, the increase of the solar thermal gain of the system with rotation of the collectors represents 16.23%. One of the methods is to use simulation tools to simulate different conditions of solar energy flow. A model in the Ansys software was developed for solar thermal flat collectors. The model is based on setting the material parameters of the collector construction, the properties of the absorber in terms of absorption as well as the materials and its geometry, the properties of the heat transfer medium, and the setting of the volume flows. At the same time, it is possible to define the change in the energy flow of the incident radiation. The model is a useful tool for evaluating collectors used by different tracking systems. The model was experimentally verified on a tracker system and compared with experimental data with good agreement. For sunny days, the model shows an accuracy rate of 98.7% in the condition without rotation, and 99.1% in the condition with rotation of the collector. After including the 5% degree of uncertainty for the condition of the rotated collectors, the accuracy of the model is 94.2% and for the condition without rotation 93.8%.
Multicriteria Decision Approach to the Design of Floating Wind Farm Export Cables
Authors: Díaz Hugo , Guedes Soares C.
Published: September 2022

This paper addresses subsea electric cable routing using the application of decision support systems combined with the experts’ knowledge. The methodology is successfully applied to a case study on the Spanish coast. The ranking method calculates the multiple criteria weights, and the weighted product method determines the most suitable space. The environmental criteria, with a weight of 61.4%, exceed the significance of other essential criteria in the study based on experts’ considerations. These rankings are input into the model to extract the suitable spaces to deploy the underwater cable. The final result accurately highlights an optimal route in alignment with the experts’ preferences.
Experimental Study on Pressure Relief Mechanism of Variable-Diameter Borehole and Energy Evolution Characteristics of the Surrounding Rock
Authors: Li Yangyang , Guo Rongwei , Zhang Shichuan , Chen Bing , Yan Haodong , Meng Wenhang , Zheng Dan
Published: September 2022

Conventional borehole pressure relief can meet the requirements for preventing rock bursts, but it can also easily destroy the roadway, resulting in system support failure. Taking coal-like samples with boreholes as the research object, the pressure relief effects of the same-diameter boreholes and variable-diameter boreholes are compared and analyzed by a uniaxial compression test. The joint pressure relief mechanism of the variable-diameter drilling hole is discussed. The experimental results show that the stress–strain curve of variable-diameter drilling sample occurred the phenomenon of pre-peak stress drop and post-peak stress plateau, which indicates that the variable-diameter drilling hole can enhance the plastic characteristics of coal-like samples. The borehole size dramatically influences the variation of various pressure relief indexes. The evolution law of AE counting the pre-peak and post-peak of borehole samples verified the abovementioned law. Variable-diameter drilling can enhance the plasticity of samples, weaken the brittleness and reduce the impact tendency. Under the maximum size of the variable-diameter drilling hole and the same-diameter drilling hole is same, the pressure relief effect is more significant. The results obtained in this paper can provide a new theoretical basis and technical guidance for borehole pressure relief and roadway support.
Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
Authors: Liu Yazhou , Liu Chunlong , Kou Xiaohong , Wang Yumeng , Yu Yue , Zhen Ni , Jiang Jingyu , Zhaxi Puba , Xue Zhaohui
Published: September 2022

Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications.
Quercetin/Hydroxypropyl-β-Cyclodextrin Inclusion Complex-Loaded Hydrogels for Accelerated Wound Healing
Authors: Wangsawangrung Nutsarun , Choipang Chasuda , Chaiarwut Sonthaya , Ekabutr Pongpol , Suwantong Orawan , Chuysinuan Piyachat , Techasakul Supanna , Supaphol Pitt
Published: September 2022

This study concentrated on developing quercetin/cyclodextrin inclusion complex-loaded polyvinyl alcohol (PVA) hydrogel for enhanced stability and solubility. Quercetin was encapsulated in hydroxypropyl-β-cyclodextrin (HP-β-CD) by the solvent evaporation method. The prepared quercetin/HP-β-CD inclusion complex showed 90.50 ± 1.84% encapsulation efficiency (%EE) and 4.67 ± 0.13% loading capacity (%LC), and its successful encapsulation was confirmed by FT-IR and XRD. The quercetin/HP-β-CD inclusion complex was well dispersed in viscous solutions of PVA in various amounts (0.5, 1.0, 1.5. 2.5, and 5.0% w/v ratio), and the drug-loaded polymer solution was physically crosslinked by multiple freeze–thaw cycles to form the hydrogel. The cumulative amount of quercetin released from the prepared hydrogels increased with increasing concentrations of the inclusion complex. The introduction of the inclusion complex into the PVA hydrogels had no influence on their swelling ratio, but gelation and compressive strength reduced with increasing inclusion complex concentration. The potential cytotoxicity of quercetin/HP-β-CD inclusion complex hydrogels was evaluated by MTT assay and expressed as % cell viability. The results show biocompatibility toward NCTC 929 clone cells. The inhibitory efficacy was evaluated with 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, and the results show a higher level of antioxidant activity for quercetin/HP-β-CD inclusion complex hydrogels compared with free quercetin. The findings of our study indicate that the developed quercetin/HP-β-CD inclusion complex hydrogels possess the required properties and can be proposed as a quercetin delivery system for wound-healing applications.
Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
Authors: Ito Sohei , Lu Hong S. , Daugherty Alan , Sawada Hisashi
Published: September 2022

Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
The Benefits of Family Screening in Rare Diseases: Genetic Testing Reveals 165 New Cases of Fabry Disease among At-Risk Family Members of 83 Index Patients
Authors: Moiseev Sergey , Tao Ekaterina , Moiseev Alexey , Bulanov Nikolay , Filatova Ekaterina , Fomin Victor , Germain Dominique P.
Published: September 2022

Background: Fabry disease (FD, OMIM #301500) is a rare, progressive, X-linked, inherited genetic disease caused by a functional deficiency of lysosomal α-galactosidase, leading to the accumulation of glycosphingolipids in virtually all of the body’s cell types and fluids. Patients with rare genetic diseases and non-specific symptoms often experience substantial diagnostic delays, which can negatively impact the prompt initiation of treatment. If FD is not treated specifically, end organ damage (such as chronic renal failure, hypertrophic cardiomyopathy with arrhythmia, and strokes) impairs quality of life and reduces life expectancy. Patients and Methods: For 83 consecutive patients with FD referred to the Russian reference center for lysosomal storage diseases, family trees were built and genetic testing (cascade genotyping) was offered to family members. Results: The pathogenic GLA variant associated with FD was identified for all 83 probands. Family testing using cascade genotyping enabled the identification of 165 additional cases of FD among the tested 331 at-risk family members. Discussion: This is the first study to have described family screening in a large Russian cohort of patients with FD and chronic kidney disease. Raising awareness of FD among clinicians is important for earlier diagnosis and specific treatment.
Infection Route of Parvimonas micra: A Case Report and Systematic Review
Authors: Shimizu Kai , Horinishi Yuta , Sano Chiaki , Ohta Ryuichi
Published: September 2022

Parvimonas micra (P. micra), a bacterium that colonizes the gastrointestinal tract, is often isolated from periodontitis and abscesses as part of a complex bacterial infection. However, reports of monobacterium infections due to P. micra are limited. Here, we report a case of monobacterial bacteremia caused by P. micra with the aim of identifying the source of the invasion and clarifying the clinical features. A 54-year-old patient presented with bacteremia due to P. micra and with an oral invasion that we suspected resulted from prior dental treatment. Using PubMed and Google Scholar databases, we undertook a systematic review of monobacteremia caused by P. micra. We identified 26 patients (mean age, 70.15 years) in our systematic review. P. micra bacteremia and its associated phenotypes were most frequently identified in spinal discitis, followed by epidural and lumbar abscesses, and infective endocarditis. The major risk factors were malignancy, diabetes mellitus, and post-arthroplasty. When P. micra is detected in blood cultures, evaluation and intervention for oral contamination may be indicated.
Differences between Healthy-Weight and Overweight Serbian Preschool Children in Motor and Cognitive Abilities
Authors: Banjevic Boris , Aleksic Dragana , Aleksic Veljkovic Aleksandra , Katanic Borko , Masanovic Bojan
Published: September 2022

The aim of this study was to determine the differences between healthy-weight and overweight 5–6-year-old preschool children in fine and gross motor skills and cognitive abilities. There were 91 subjects, preschool children (41 boys and 50 girls), who participated in this cross-sectional study. The body mass index (BMI) was calculated based on measures of body height and body mass, and WHO cutoff points were used for the assessment of the children’s nutrition status. Fine motor abilities were determined using two Bruininks–Oseretsky (BOT-2) subtests, and gross motor skills are determined by the Test of Gross Motor Development (TGMD-2), while cognitive abilities were tested by the School Maturity Test (TZŠ+). Based on an independent-samples t-test, a difference in two out of three variables of gross motor skills was determined: manipulative skills and total gross motor skills between healthy-weight and overweight children, while in fine motor abilities and cognitive abilities there was no difference between these two groups. Although significant differences were found only in gross motor skills between healthy and overweight preschool children but not in fine motor skills and cognitive abilities, further longitudinal studies are required to understand the mechanisms of this, including the possible role of psychological factors.