bluuebunny/crossref_metadata_2025 huggingface dataset:
Mineralogical and Chemical Specificity of Dusts Originating from Iron and Non-Ferrous Metallurgy in the Light of Their Magnetic Susceptibility
Authors: Jabłońska Mariola , Rachwał Marzena , Wawer Małgorzata , Kądziołka-Gaweł Mariola , Teper Ewa , Krzykawski Tomasz , Smołka-Danielowska Danuta
Published: February 2021

This study aims at detailed characteristics and comparison between dusts from various iron and non-ferrous metal production processes in order to identify individual mineral phases, chemical composition, and their influence on the values of magnetic susceptibility. Various analytical methods used include inductively coupled plasma optical emission spectroscopy, X-ray diffraction, scanning electron microscopy, and Mössbauer spectroscopy integrated with magnetic susceptibility measurements and thermomagnetic analysis. Metallurgical wastes that have arisen at different production stages of iron and non-ferrous steel are subjected to investigation. The analyzed dust samples from the iron and non-ferrous metallurgy differ in terms of magnetic susceptibility as well as their mineral and chemical composition. The research confirmed the presence of many very different mineral phases. In particular, interesting phases have been observed in non-ferrous dust, for example challacolloite, which was found for the first time in the dusts of non-ferrous metallurgy. Other characteristic minerals found in non-ferrous metallurgy dusts are zincite, anglesite, and lanarkite, while dusts of iron metallurgy contain mostly metallic iron and iron-bearing minerals (magnetite, hematite, franklinite, jacobsite, and wüstite), but also significant amounts of zincite and calcite.
Soil Biochemical Indicators and Biological Fertility in Agricultural Soils: A Case Study from Northern Italy
Authors: Vittori Antisari Livia , Ferronato Chiara , De Feudis Mauro , Natali Claudio , Bianchini Gianluca , Falsone Gloria
Published: February 2021

Industrial farming without considering soil biological features could lead to soil degradation. We aimed to evaluate the biochemical properties (BPs) and biological fertility (BF) of different soils under processing tomato cultivation; estimate the BF through the calculation of a simplified BF index (BFIs); determine if the crop was affected by BP and BF. Three farms were individuated in Modena (MO), Ferrara (MEZ) and Ravenna (RA) provinces, Italy. Soil analysis included total and labile organic C, microbial biomass-C (Cmic) and microbial respiration measurements. The metabolic (qCO2), mineralization (qM) and microbial (qMIC) quotients, and BFIs were calculated. Furthermore, plant nutrient contents were determined. The low Cmic content and qMIC, and high qCO2 found in MEZ soils indicate the occurrence of stressful conditions. The high qMIC and qM, and the low qCO2 demonstrated an efficient organic carbon incorporation as Cmic in MO soils. In RA soils, the low total and labile organic C contents limited the Cmic and microbial respiration. Therefore, as confirmed by the BFIs, while MO showed the healthiest soils, RA soils had an inefficient ecophysiological energy state. However, no effects on plant nutrient contents were observed, likely because of masked by fertigation. Finally, BP monitoring is needed in order to avoid soil degradation and, in turn, crop production decline.
Enriched Co-Treatment of Pharmaceutical and Acidic Metal-Containing Wastewater with Nano Zero-Valent Iron
Authors: Makhathini Thobeka Pearl , Mulopo Jean , Bakare Babatunde Femi
Published: February 2021

Among traditional hazardous waste sources, pharmaceutical-containing wastewater and acidic mine drainage need treatment to preserve the expected water supply quality. A nano zero-valent iron (nZVI)-enriched treatment of these two streams is evaluated for simultaneous removal of various heavy metal ions, organic pollutants, sulfates, the efficiency of the treatment system, and separation of reaction products in the fluidized-bed reactor. The reactor packed with silica sand was inoculated with sludge from an anaerobic digester, then 1–3 g/L of nZVI slurry added to cotreat a hospital feed and acid mine wastewater at 5:2 v/v. The biotreatment process is monitored through an oxidation–reduction potential (Eh) for 90 days. The removal pathway for the nZVI used co-precipitation, sorption, and reduction. The removal load for Zn and Mn was approximately 198 mg Zn/g Fe and 207 mg Mn/g Fe, correspondingly; achieving sulfate (removal efficiency of 94% and organic matter i.e., chemical oxygen demand (COD), biological oxygen demand (BOD), dissolved organic carbon (DOC), total dissolved nitrogen (TDN) reduced significantly, but ibuprofen and naproxen achieved 31% and 27% removal, respectively. This enriched cotreatment system exhibited a high reducing condition in the reactor, as confirmed by Eh; hence, the nZVI was dosed only a few times in biotreatment duration, demonstrating a cost-effective system.
Analysis of the Effect of Payment Mechanism on Exploitation of Polymetallic Nodules in the Area
Authors: Li Yan , Liu Chang , Su Sihan , Li Mengdan , Liu Shaojun
Published: February 2021

The international seabed area (i.e., the “Area”) is rich in mineral resources. According to the United Nations Convention on the Law of the Sea (UNCLOS) and the relevant implemented agreements, in 2012, the International Seabed Authority (ISA) began to develop the regulations for the exploitation of mineral resources in the Area. The most important part of the regulations involves determining the distribution of benefits from the exploitation of mineral resources in the Area between the ISA and the contractors. The establishment of a financial model to evaluate the economic benefits and compare the distribution scheme was the basic method relied on in the current study of payment mechanism. According to the characteristics of the exploitation project of mineral resources in the Area, the discounted cash flow method was selected to construct the financial model. Taking China’s deep-sea mineral resources development project in the Area as the background, the main parameters of the model were determined. A comparative study of similar financial models with Massachusetts Institute of Technology (MIT) and other foreign countries was carried out, in addition to a sensitivity analysis of parameters. On the basis of the assurance that the contractor’s internal rate of return was not lower than the level of the land mining enterprise, the financial model was used to calculate the internal rate of return and the revenue of royalty under different payment mechanisms and rates. The advantages and disadvantages of different payment mechanisms in the exploitation of mineral resources in the area were analyzed. Lastly, the possible impacts of deep-sea polymetallic nodule mining on Terrestrial metal markets were highlighted.
Identification of Selected Tuna Species in Commercial Products
Authors: Servusova Eliska , Piskata Zora
Published: February 2021

This study was conducted to develop systems for the identification of four tuna species (skipjack tuna Katsuwonus pelamis, yellowfin tuna Thunnus albacares, bullet tuna Auxis sp. and Atlantic bonito Sarda sp). At first, raw samples of these species and a mix intended as internal control were prepared for the authentication of fish muscle tissue of the genus Thunnus sp., Auxis sp. and Sarda sp. DNA from raw muscle tissue, the mix and samples was extracted with the DNeasy mericon Food Kit (Qiagen GmbH, Hilden, Germany). The concentration and purity of DNA in raw samples were evaluated using a spectrophotometer. Primers and probe sequences were specifically designed to identify the selected species. In addition, primers and a probe for the endogenous 12S rRNA gene were designed to determine the presence of amplifiable fish (especially tuna) DNA in samples. Furthermore, the species specificity of the designed primers and probes was verified in DNA samples of various tuna and bonito species. Limit of detection for the selected species was calculated as well as the coefficient of determination R2 and efficiency of real-time PCR testing was determined. To evaluate the developed real-time PCR methods, 70 commercial tuna products were analysed. The results show that mislabelling of fish products can still be encountered and, moreover, the presence of an additional species can be identified.
Magnetic Mesoporous Carbon/β-Cyclodextrin–Chitosan Nanocomposite for Extraction and Preconcentration of Multi-Class Emerging Contaminant Residues in Environmental Samples
Authors: Mashile Geaneth Pertunia , Mpupa Anele , Nomngongo Philiswa Nosizo
Published: February 2021

This study reports the development of magnetic solid-phase extraction combined with high-performance liquid chromatography for the determination of ten trace amounts of emerging contaminants (fluoroquinolone antibiotics, parabens, anticonvulsants and β-blockers) in water systems. Magnetic mesoporous carbon/β-cyclodextrin–chitosan (MMPC/Cyc-Chit) was used as an adsorbent in dispersive magnetic solid-phase extraction (DMSPE). The magnetic solid-phase extraction method was optimized using central composite design. Under the optimum conditions, the limits of detection (LODs) ranged from 0.1 to 0.7 ng L−1, 0.5 to 1.1 ng L−1 and 0.2 to 0.8 ng L−1 for anticonvulsants and β-blockers, fluoroquinolone and parabens, respectively. Relatively good dynamic linear ranges were obtained for all the investigated analytes. The repeatability (n = 7) and reproducibility (n = 5) were less than 5%, while the enrichment factors ranged between 90 and 150. The feasibility of the method in real samples was assessed by analysis of river water, tap water and wastewater samples. The recoveries for the investigated analytes in the real samples ranged from 93.5 to 98.8%, with %RSDs under 4%.
Towards the Development of Antioxidant Cerium Oxide Nanoparticles for Biomedical Applications: Controlling the Properties by Tuning Synthesis Conditions
Authors: Gallucci Noemi , Vitiello Giuseppe , Di Girolamo Rocco , Imbimbo Paola , Monti Daria Maria , Tarallo Oreste , Vergara Alessandro , Russo Krauss Irene , Paduano Luigi
Published: February 2021

In this work CeO2 nanoparticles (CeO2-NPs) were synthesized through the thermal decomposition of Ce(NO3)3·6H2O, using as capping agents either octylamine or oleylamine, to evaluate the effect of alkyl chain length, an issue at 150 °C, in the case of octylamine and at 150 and 250 °C, in the case of oleylamine, to evaluate the effect of the temperature on NPs properties. All the nanoparticles were extensively characterized by a multidisciplinary approach, such as wide-angle X-ray diffraction, transmission electron microscopy, dynamic light scattering, UV-Vis, fluorescence, Raman and FTIR spectroscopies. The analysis of the experimental data shows that the capping agent nature and the synthesis temperature affect nanoparticle properties including size, morphology, aggregation and Ce3+/Ce4+ ratio. Such issues have not been discussed yet, at the best of our knowledge, in the literature. Notably, CeO2-NPs synthesized in the presence of oleylamine at 250 °C showed no tendency to aggregation and we made them water-soluble through a further coating with sodium oleate. The obtained nanoparticles show a less tendency to clustering forming stable aggregates (ranging between 14 and 22 nm) of few NPs. These were tested for biocompatibility and ROS inhibiting activity, demonstrating a remarkable antioxidant activity, against oxidative stress.
Bio-Separated and Gate-Free 2D MoS2 Biosensor Array for Ultrasensitive Detection of BRCA1
Authors: Zhang Yi , Jiang Wei , Feng Dezhi , Wang Chenguang , Xu Yi , Shan Yufeng , Wang Jianlu , Yin Ziwei , Deng Huiyong , Mi Xianqiang , Dai Ning
Published: February 2021

2D molybdenum disulfide (MoS2)-based thin film transistors are widely used in biosensing, and many efforts have been made to improve the detection limit and linear range. However, in addition to the complexity of device technology and biological modification, the compatibility of the physical device with biological solutions and device reusability have rarely been considered. Herein, we designed and synthesized an array of MoS2 by employing a simple-patterned chemical vapor deposition growth method and meanwhile exploited a one-step biomodification in a sensing pad based on DNA tetrahedron probes to form a bio-separated sensing part. This solves the signal interference, solution erosion, and instability of semiconductor-based biosensors after contacting biological solutions, and also allows physical devices to be reused. Furthermore, the gate-free detection structure that we first proposed for DNA (BRCA1) detection demonstrates ultrasensitive detection over a broad range of 1 fM to 1 μM with a good linear response of R2 = 0.98. Our findings provide a practical solution for high-performance, low-cost, biocompatible, reusable, and bio-separated biosensor platforms.
Assessing Overall Diet Quality: Development and Evaluation of the Performance of a Short Self-Administrated Questionnaire SCASA
Authors: Kruseman Maaike , Chatelan Angeline , Farina Eddy , Carrard Isabelle , Cela Jeremy , Guessous Idris , Marques-Vidal Pedro
Published: February 2021

Several tools assessing diet quality have been developed over the last decades, but their use in public health and clinical practice is limited because they necessitate detailed quantitative assessment of food intake. Our goal was to develop and validate a score (Score d’Alimentation Saine, SCASA) based on a short self-administrated online questionnaire to assess overall diet quality. SCASA targets the adult population in French-speaking Switzerland, but it was designed in a way enabling its adaptation for other regions. The choice of the items involved experts and lay volunteers. Construct validation and inter-method reliability were assessed by screening meal plans and by comparing the self-rated scores with food-record derived scores (kappa and Bland–Altman). SCASA (17 components) discriminated adequately balanced from imbalanced meal plans (93–95% and 44–46% of maximal score). Agreement between self-assessed and food record-based scores ranged between >90% (3 items), 80–89% (3 items), 70–79% (4 items), and <70% (5 items). The Bland–Altman plot showed a mean difference of −1.60 (95% CI −2.36 to −0.84), indicating a slight overestimation of the self-assessed diet quality compared to the food record. SCASA offers a reliable way to assess overall diet quality without requiring burdensome data collection or nutrient calculations.
Effectiveness of Breastfeeding Support Packages in Low- and Middle-Income Countries for Infants under Six Months: A Systematic Review
Authors: Rana Ritu , McGrath Marie , Sharma Ekta , Gupta Paridhi , Kerac Marko
Published: February 2021

Small and nutritionally at-risk infants under six months, defined as those with wasting, underweight, or other forms of growth failure, are at high-risk of mortality and morbidity. The World Health Organisation 2013 guidelines on severe acute malnutrition highlight the need to effectively manage this vulnerable group, but programmatic challenges are widely reported. This review aims to inform future management strategies for small and nutritionally at-risk infants under six months in low- and middle-income countries (LMICs) by synthesising evidence on existing breastfeeding support packages for all infants under six months. We searched PubMed, CINAHL, Cochrane Library, EMBASE, and Global Health databases from inception to 18 July 2018. Intervention of interest were breastfeeding support packages. Studies reporting breastfeeding practices and/or caregivers’/healthcare staffs’ knowledge/skills/practices for infants under six months from LMICs were included. Study quality was assessed using NICE quality appraisal checklist for intervention studies. A narrative data synthesis using the Synthesis Without Meta-analysis (SWiM) reporting guideline was conducted and key features of successful programmes identified. Of 15,256 studies initially identified, 41 were eligible for inclusion. They were geographically diverse, representing 22 LMICs. Interventions were mainly targeted at mother–infant pairs and only 7% (n = 3) studies included at-risk infants. Studies were rated to be of good or adequate quality. Twenty studies focused on hospital-based interventions, another 20 on community-based and one study compared both. Among all interventions, breastfeeding counselling (n = 6) and education (n = 6) support packages showed the most positive effect on breastfeeding practices followed by breastfeeding training (n = 4), promotion (n = 4) and peer support (n = 3). Breastfeeding education support (n = 3) also improved caregivers’ knowledge/skills/practices. Identified breastfeeding support packages can serve as "primary prevention" interventions for all infants under six months in LMICs. For at-risk infants, these packages need to be adapted and formally tested in future studies. Future work should also examine impacts of breastfeeding support on anthropometry and morbidity outcomes. The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO 2018 CRD42018102795).
Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study
Authors: Menzel Juliane , Abraham Klaus , Stangl Gabriele I. , Ueland Per Magne , Obeid Rima , Schulze Matthias B. , Herter-Aeberli Isabelle , Schwerdtle Tanja , Weikert Cornelia
Published: February 2021

Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. This study revealed lower levels in the QUS parameters in vegans compared to omnivores, e.g., broadband ultrasound attenuation (vegans: 111.8 ± 10.7 dB/MHz, omnivores: 118.0 ± 10.8 dB/MHz, p = 0.02). Vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium levels, while the concentrations of vitamin K1, folate, and glutamine were higher in vegans compared to omnivores. Applying a reduced rank regression, 12 out of the 28 biomarkers were identified to contribute most to bone health, i.e., lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. All QUS parameters increased across the tertiles of the pattern score. The study provides evidence of lower bone health in vegans compared to omnivores, additionally revealing a combination of nutrition-related biomarkers, which may contribute to bone health. Further studies are needed to confirm these findings.
Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation
Authors: Maigoro Abdulkadir Yusif , Lee Soojin
Published: February 2021

The link between autism spectrum disorder (ASD) and the gut microbiome has received much attention, with special focus on gut–brain-axis immunological imbalances. Gastrointestinal problems are one of the major symptoms of ASD and are thought to be related to immune dysregulation. Therefore, in silico analysis was performed on mined data from 36 individuals with ASD and 21 control subjects, with an emphasis on lipid A endotoxin-producing bacteria and their lipopolysaccharide (LPS) metabolic pathways. Analysis of enzyme distribution among the 15 most abundant genera in both groups revealed that almost all these genera utilized five early-stage enzymes responsible for catalyzing the nine conserved lipid A synthesis steps. However, Haemophilus and Escherichia, which were significantly more abundant in individuals with ASD than in the control subjects, possess a complete set of essential lipid A synthesis enzymes. Furthermore, the 10 genera with the greatest increase in individuals with ASD showed high potential for producing late-stage lipid A products. Collectively, these results suggested that the synthesis rate of immunogenic LPS end products is likely to increase in individuals with ASD, which may be related to their gastrointestinal symptoms and elevated inflammatory conditions.
Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice
Authors: Drews Henning Johannes , Klein Roman , Lourhmati Ali , Buadze Marine , Schaeffeler Elke , Lang Thomas , Seferyan Torgom , Hanson Leah R. , Frey II William H. , de Vries Tom C.G.M. , Thijssen-van Loosdregt Inge A.E.W. , Gleiter Christoph H. , Schwab Matthias , Danielyan Lusine
Published: February 2021

Angiotensin receptor blockers (ARBs) have demonstrated multiple neuroprotective benefits in Alzheimer’s disease (AD) models. However, their beneficial effects on memory deficits, cholinergic activity, neurogenesis and Amyloid beta (Aβ) clearance reveal significant interstudy variability. The delivery route can impact not only delivery but also targeting and therapeutic efficacy of ARBs. Our previous findings on the beneficial effects of intranasally delivered losartan in the APP/PS1 model of AD prompted us to explore the influence of the delivery route by employing here the systemic administration of losartan. Consistent with our previous results with intranasal losartan, repeated intraperitoneal administration (10 mg/kg) resulted in a remarkable decrease in Aβ plaques and soluble Aβ42, as well as inflammatory cytokines (IL-2, IL-6 and TNFα). The Aβ reduction can be ascribed to its facilitated degradation by neprilysin and diminished generation by BACE1. Losartan increased neurogenesis in vivo and in vitro and improved migratory properties of astrocytes isolated from adult transgenic AD mice. In summary, this data together with our previous results suggest therapeutic features of losartan which are independent of delivery route. The improvement of cell motility of Aβ-affected astrocytes by losartan deserves further in vivo investigation, which may lead to new strategies for AD treatment.
Advances in Development of Radiometal Labeled Amino Acid-Based Compounds for Cancer Imaging and Diagnostics
Authors: Mikulová Mária Bodnár , Mikuš Peter
Published: February 2021

Radiolabeled biomolecules targeted at tumor-specific enzymes, receptors, and transporters in cancer cells represent an intensively investigated and promising class of molecular tools for the cancer diagnosis and therapy. High specificity of such biomolecules is a prerequisite for the treatment with a lower burden to normal cells and for the effective and targeted imaging and diagnosis. Undoubtedly, early detection is a key factor in efficient dealing with many severe tumor types. This review provides an overview and critical evaluation of novel approaches in the designing of target-specific probes labeled with metal radionuclides for the diagnosis of most common death-causing cancers, published mainly within the last three years. Advances are discussed such traditional peptide radiolabeling approaches, and click and nanoparticle chemistry. The progress of radiolabeled peptide based ligands as potential radiopharmaceuticals is illustrated via novel structure and application studies, showing how the molecular modifications reflect their binding selectivity to significant onco-receptors, toxicity, and, by that, practical utilization. The most impressive outputs in categories of newly developed structures, as well as imaging and diagnosis approaches, and the most intensively studied oncological diseases in this context, are emphasized in order to show future perspectives of radiometal labeled amino acid-based compounds in nuclear medicine.
Non-Coding RNAs: The “Dark Side Matter” of the CLL Universe
Authors: Lingua Marcello Francesco , Carrà Giovanna , Maffeo Beatrice , Morotti Alessandro
Published: February 2021

For many years in the field of onco-hematology much attention has been given to mutations in protein-coding genes or to genetic alterations, including large chromosomal losses or rearrangements. Despite this, biological and clinical needs in this sector remain unmet. Therefore, it is not surprising that recent studies have shifted from coded to non-coded matter. The discovery of non-coding RNAs (ncRNAs) has influenced several aspects related to the treatment of cancer. In particular, in chronic lymphocytic leukemia (CLL) the knowledge of ncRNAs and their contextualization have led to the identification of new biomarkers used to follow the course of the disease, to the anticipation of mechanisms that support resistance and relapse, and to the selection of novel targeted treatment regimens. In this review, we will summarize the main ncRNAs discovered in CLL and the molecular mechanisms by which they are affected and how they influence the development and the progression of the disease.
In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions
Authors: Khotimchenko Maksim , Antontsev Victor , Chakravarty Kaushik , Hou Hypatia , Varshney Jyotika
Published: February 2021

The use of opioid analgesics in treating severe pain is frequently associated with putative adverse effects in humans. Topical agents that are shown to have high efficacy with a favorable safety profile in clinical settings are great alternatives for pain management of multimodal analgesia. However, the risk of side effects induced by transdermal absorption and systemic exposure is of great concern as they are challenging to predict. The present study aimed to use “BIOiSIM” an artificial intelligence-integrated biosimulation platform to predict the transdermal disposition of opioid analgesics. The model successfully predicted their exposure following the topical application of central opioid agonist buprenorphine and peripheral agonist oxycodone in healthy human subjects with simulation of intra-skin exposure in subjects with burns and pressure wounds. The predicted plasma levels of analgesics were used to evaluate the safety of the therapeutic pain control in patients with the dermal structural impairments caused by acute (burns) or chronic cutaneous lesions (pressure wounds) with topical opioid analgesics.
The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review
Authors: Jummaat Fauziah , Yahya Esam Bashir , Khalil H.P.S. Abdul , Adnan A. S. , Alqadhi Amaal Mohammed , Abdullah C. K. , A.K. Atty Sofea , Olaiya N. G. , Abdat Munifah
Published: February 2021

Biopolymers have gained tremendous attention in many daily life applications, including medical applications, in the past few years. Obstetrics and gynecology are two fields dealing with sensitive parts of the woman’s body and her newborn baby, which are normally associated with many issues such as toxicity, infections, and even gene alterations. Medical professions that use screening, examination, pre, and post-operation materials should benefit from a better understanding of each type of material’s characteristics, health, and even environmental effects. The underlying principles of biopolymer-based materials for different obstetric and gynecologic applications may discover various advantages and benefits of using such materials. This review presents the health impact of conventional polymer-based materials on pregnant women’s health and highlights the potential use of biopolymers as a safer option. The recent works on utilizing different biopolymer-based materials in obstetric and gynecologic are presented in this review, which includes suture materials in obstetric and gynecologic surgeries, cosmetic and personal care products, vaginal health, and drug delivery; as well as a wound dressing and healing materials. This review highlights the main issues and challenges of biopolymers in obstetric and gynecologic applications.
Sustainable Esterification of a Soda Lignin with Phloretic Acid
Authors: Adjaoud Antoine , Dieden Reiner , Verge Pierre
Published: February 2021

In this work, a sustainable chemical process was developed through the Fischer esterification of Protobind® lignin, a wheat straw soda lignin, and phloretic acid, a naturally occurring phenolic acid. It aimed at increasing the reactivity of lignin by enhancing the number of unsubstituted phenolic groups via a green and solvent-free chemical pathway. The structural features of the technical and esterified lignins were characterized by complementary spectroscopic techniques, including 1H, 13C, 31P, and two-dimensional analysis. A substantial increase in p-hydroxyphenyl units was measured (+64%, corresponding to an increase of +1.3 mmol g−1). A full factorial design of the experiment was employed to quantify the impact of critical variables on the conversion yield. The subsequent statistical analysis suggested that the initial molar ratio between the two precursors was the factor predominating the yield of the reaction. Hansen solubility parameters of both the technical and esterified lignins were determined by solubility assays in multiple solvents, evidencing their high solubility in common organic solvents. The esterified lignin demonstrated a better thermal stability as the onset of thermal degradation shifted from 157 to 220 °C, concomitantly to the shift of the glass transition from 92 to 112 °C. In conclusion, the esterified lignin showed potential for being used as sustainable building blocks for composite and thermoset applications.
Eco-Friendly Fiberboard Panels from Recycled Fibers Bonded with Calcium Lignosulfonate
Authors: Antov Petar , Krišt’ák L’uboš , Réh Roman , Savov Viktor , Papadopoulos Antonios N.
Published: February 2021

The potential of using residual softwood fibers from the pulp and paper industry for producing eco-friendly, zero-formaldehyde fiberboard panels, bonded with calcium lignosulfonate (CLS) as a lignin-based, formaldehyde free adhesive, was investigated in this work. Fiberboard panels were manufactured in the laboratory by applying CLS addition content ranging from 8% to 14% (on the dry fibers). The physical and mechanical properties of the developed composites, i.e., water absorption (WA), thickness swelling (TS), modulus of elasticity (MOE), bending strength (MOR), as well as the free formaldehyde emission, were evaluated according to the European norms. In general, only the composites, developed with 14% CLS content, exhibited MOE and MOR values, comparable with the standard requirements for medium-density fiberboards (MDF) for use in dry conditions. All laboratory-produced composites demonstrated significantly deteriorated moisture-related properties, i.e., WA (24 h) and TS (24 h), which is a major drawback. Noticeably, the fiberboards produced had a close-to-zero formaldehyde content, reaching the super E0 class (≤1.5 mg/100 g), with values, ranging from 0.8 mg/100 g to 1.1 mg/100 g, i.e., equivalent to formaldehyde emission of natural wood. The amount of CLS adhesive had no significant effect on formaldehyde content.
Steady-State Conduction Current Performance for Multilayer Polyimide/SiO2 Films
Authors: Bhutta Muhammad Shoaib , Akram Shakeel , Meng Pengfei , Castellon Jerome , Agnel Serge , Li Hui , Guo Yecai , Rasool Ghulam , Hussain Shahid , Nazir Muhammad Tariq
Published: February 2021

The steady-state electrical conduction current for single and multilayer polyimide (PI) nanocomposite films was observed at the low and high electric field for different temperatures. Experimental data were fitted to conduction models to investigate the dominant conduction mechanism in these films. In most films, space charge limited current (SCLC) and Poole–Frenkel current displayed dominant conduction. At a high electric field, the ohmic conduction was replaced by current–voltage dependency. Higher conduction current was observed for nanocomposite films at a lower temperature, but it declined at a higher temperature. PI nanocomposite multilayer films showed a huge reduction in the conduction current at higher electric fields and temperatures. The conclusions derived in this study would provide the empirical basis and early breakdown phenomenon explanation when performing dielectric strength and partial discharge measurements of PI-based nanocomposite insulation systems of electric motors.
Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments
Authors: Rahdar Abbas , Sargazi Saman , Barani Mahmood , Shahraki Sheida , Sabir Fakhara , Aboudzadeh M.
Published: February 2021

Encapsulation of the chemotherapy agents within colloidal systems usually improves drug efficiency and decreases its toxicity. In this study, lignin (LGN) (the second most abundant biopolymer next to cellulose on earth) was employed to prepare novel doxorubicin (DOX)-loaded oil-in-water (O/W) microemulsions with the aim of enhancing the bioavailability of DOX. The droplet size of DOX-loaded microemulsion was obtained as ≈ 7.5 nm by dynamic light scattering (DLS) analysis. The entrapment efficiency (EE) % of LGN/DOX microemulsions was calculated to be about 82%. In addition, a slow and sustainable release rate of DOX (68%) was observed after 24 h for these microemulsions. The cytotoxic effects of standard DOX and LGN/DOX microemulsions on non-malignant (HUVEC) and malignant (MCF7 and C152) cell lines were assessed by application of a tetrazolium (MTT) colorimetric assay. Disruption of cell membrane integrity was investigated by measuring intracellular lactate dehydrogenase (LDH) leakage. In vitro experiments showed that LGN/DOX microemulsions induced noticeable morphological alterations and a greater cell-killing effect than standard DOX. Moreover, LGN/DOX microemulsions significantly disrupted the membrane integrity of C152 cells. These results demonstrate that encapsulation and slow release of DOX improved the cytotoxic efficacy of this anthracycline agent against cancer cells but did not improve its safety towards normal human cells. Overall, this study provides a scientific basis for future studies on the encapsulation efficiency of microemulsions as a promising drug carrier for overcoming pharmacokinetic limitations.
Synthesis and Characterization of Magnetic Xerogel Monolith as an Adsorbent for As(V) Removal from Groundwater
Authors: Khamkure Sasirot , Garrido-Hoyos Sofía Esperanza , Gamero-Melo Prócoro , Reyes-Rosas Audberto
Published: February 2021

Arsenic contamination of groundwater is still a global problem due to the toxicity at low dose on human health confirmed by epidemiological studies. Magnetic xerogel monoliths (MXs) were synthesized by the sol-gel polymerization using resorcinol, formaldehyde, alkaline catalyst and magnetite. The varying molar ratios of magnetite and resorcinol (M/R) in the gel were evaluated for As(V) removal from groundwater. The surface chemistry, structure and morphology of MXs related to arsenic adsorption were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and point of zero charge. Batch adsorption experiments were carried out to investigate the effects of Fe contents, initial pH and adsorbent dose on As(V) removal performance. The MXs with molar ratio of M/R at 0.15 gave the maximum As(V) adsorption capacity and removal with values of 62.8 µg/g and 86.7%, respectively. The adsorption data were well described by the Elovich equation of the kinetic model and the Freundlich isotherm. The thermodynamic studies demonstrated that the adsorption process was endothermic and spontaneous in nature. MXs showed to be a good alternative for As(V) removal from groundwater and achieving the efficient desorption, and thus fulfilled the Mexican standard for drinking water.
Recent Developments in Carbon Quantum Dots: Properties, Fabrication Techniques, and Bio-Applications
Authors: El-Shabasy Rehan M. , Farouk Elsadek Mohamed , Mohamed Ahmed Badreldin , Fawzy Farahat Mohamed , Mosleh Khaled N. , Taher Mohamed M.
Published: February 2021

Carbon dots have gained tremendous interest attributable to their unique features. Two approaches are involved in the fabrication of quantum dots (Top-down and Bottom-up). Most of the synthesis methods are usually multistep, required harsh conditions, and costly carbon sources that may have a toxic effect, therefore green synthesis is more preferable. Herein, the current review presents the green synthesis of carbon quantum dots (CQDs) and graphene quantum dots (GQDs) that having a wide range of potential applications in bio-sensing, cellular imaging, and drug delivery. However, some drawbacks and limitations are still unclear. Other biomedical and biotechnological applications are also highlighted.
Effective Desulfurization and Alumina Digestion of High-Sulfur Bauxite by New Roasting Process with Conveying Bed
Authors: Zhao Bo , Chen Yanxin , Jiu Shaowu
Published: February 2021

A new roasting process with a conveying bed was constructed and used to remove sulfur of high-sulfur bauxite. Roasting temperature, phase transformation, microcrystal, specific surface area of high-sulfur bauxite, and the mechanism of the reaction during the roasting process were analyzed. The digestion properties of roasted bauxite were also investigated. The results showed that the sulfur in high-sulfur bauxite can be efficiently removed by roasting in the conveying bed at 520–720 °C for 2 s. Major reactions of high-sulfur bauxite during roasting were the dehydration of minerals, desulfurization of pyrite, sulfation of SO2, and decomposition of sulfate. The rate of mineral dehydration reaction was significantly slower than that of the desulfurization reaction. The specific surface area of roasted ore greatly increased, and the microcrystal of Al-O mineral was refined, which was conducive to Al2O3 digestion. The mass fraction of sulfide sulfur in high-sulfur bauxite was reduced from 1.20% to 0.01%, and the relative digestibility of alumina reached more than 99% when roasting at 600 °C for 2 s. This paper provides revelations and instructions for the process development and application of high-sulfur bauxite.
In Situ Modification of Activated Carbons by Oleic Acid under Microwave Heating to Improve Adsorptive Removal of Naphthalene in Aqueous Solutions
Authors: Wu Zhansheng , Liu Pengyun , Wu Zhilin , Cravotto Giancarlo
Published: February 2021

This study aimed to improve the adsorption capacity of activated carbon (AC) towards naphthalene (NAP) in aqueous solutions. Starch-based AC (SAC) and pulverized coal-based AC (PCAC) were prepared in a one-pot procedure by activation with oleic acid and KOH under microwave heating. Brunauer–Emmett–Teller (BET) specific surface areas reached 725.0 and 912.9 m2/g for in situ modified SAC (O-SAC1) and PCAC (O-PCAC1), respectively. π–π bond, H-bond, and hydrophobic effects were directly involved in the NAP adsorption process. Batch adsorption data were well fitted by pseudo-second order kinetics and the Freundlich isotherm model. As compared to ACs prepared with only KOH activation, NAP adsorption capacities of PCAC and SAC prepared by the one-pot method increased by 16.9% and 13.7%, respectively. Influences of varying factors were investigated in column adsorption of NAP using O-SAC1 and O-PCAC1. Based on breakthrough curves analysis, the larger column height (H), lower flow rate (Q0), and lower initial concentration (C0) resulted in the longer breakthrough and exhaustion times in both cases. Specifically, we concluded that O-PCAC1 exhibits better adsorption capacity than O-SAC1 in the given conditions. The optimized operating parameters were 1 cm (H), 1 mL/min (Q0) and 30 mg/L (C0). Finally, column adsorption data could be well fitted by the Thomas model.
Fluorescence Enhancement on Silver-Plated Plasma Micro-Nanostructured 3D Polymeric Microarray Substrates for Multiplex Mycotoxin Detection
Authors: Koukouvinos Georgios , Karachaliou Chrysoula-Evangelia , Kanioura Anastasia , Tsougeni Katerina , Livaniou Evangelia , Kakabakos Sotirios Elias , Petrou Panagiota Sotirios
Published: February 2021

Oxygen plasma micro-nanostructured poly(methyl methacrylate) (PMMA) slides were modified through silver microparticle deposition to create microarray substrates that enhance the emitted fluorescence intensity. Silver deposition relied on a commercially available reagent and was completed in two 30-min incubation cycles of the substrate with the reagent. The fluorescence enhancement achieved using these substrates over flat PMMA slides was determined through the development of a microarray for the multiplexed detection of four mycotoxins, aflatoxin B1, ochratoxin A, fumonisin B1, and deoxynivalenol. It was shown that the implementation of silver-plated oxygen plasma micro-nanotextured PMMA substrates increased the signals obtained for aflatoxin B1 and ochratoxin A by approximately 2.8 times, 5.6 times for deoxynivalenol, and 16-times for fumonisin B1, compared to flat PMMA substrates. Most notably, this signal increase was not accompanied by a significant increase in the non-specific signal. In addition, the spot repeatability both across a single slide as well as between different slides was high, with coefficients of variation lower than 12%. The slides were also stable for at least three months, thus offering a microarray substrate with improved properties compared to standard glass slides, regarding both the absolute spot fluorescence intensity and between spots repeatability.
Face to Face with Anti-Muslim Sentiment: A Qualitative Study into the Coping Mechanisms of Young College and University Muslim Students and Graduates in Flanders
Authors: De Nolf Ans , d’Haenens Leen , Mekki-Berrada Abdelwahed
Published: February 2021

This explorative study seeks to provide insights into the ways young Muslim adults experience and cope with Islamophobia in Flanders. For this purpose, in-depth interviews with 14 Muslims aged 19 to 33 were conducted in the spring of 2020. Our interviewees defined themselves as Muslims and all had been confronted with racism or anti-Muslim sentiment in their daily life. Depending on reported intentions, we identified seven coping strategies in the face of such sentiment: relativization, avoidance, communication, oppression, conciliation, reaction and passive coping strategies. These forms of coping are not mutually exclusive. They are often used in combination, and they may be interchangeable in some situations. This study seeks to complement and deepen the existing literature on anti-Muslim sentiment in Flanders. Its findings should be considered as a starting point for further deductive testing of the identified typologies, meant to inspire follow-up research and serve as evidence for future policymaking.
Empty Night: Kashubian “Home Liturgy” in the Context of Death
Authors: Perszon Jan
Published: February 2021

Based on ethnographic field research and thanatological literature, this article analyzes the continuing, but rapidly disappearing, Kashubian custom of bidding farewell to a deceased member of the local community known as “empty night”. Its essence is the night prayer vigil in the house of the deceased, performed by neighbors and relatives. The prayer consists mainly of singing religious songs on “the last things”—in particular about purgatory, human fragility, God’s mercy, and the Passion of Christ. The efforts of the orants are motivated by the concern for the salvation of the soul of the deceased, that is, the shortening and relieving the purgatorial punishment. The centuries-old tradition of “empty night” has been rapidly disappearing over the past 50 years as a result of both economic and social transformations, the gradual erosion of living faith, and the abandonment of the priority of salvation by younger Kashubians. The progressive medicalization of life and change of the approach to death play a crucial role in weakening the tradition of the ancestors. Thus the traditional “empty night” becomes a relic of “tamed death,” giving way to its tabooization and the illusion of “technological immortality”.
Is There a Role of Religion? The Moderation Role of Religious Identity and Religious Practice between Traditional Media Usage and Moral Evaluation
Authors: Zeng Sheng , Peng Zijian , Wu Lin
Published: February 2021

Although the relationship between traditional media usage and moral evaluation has been studied in China, it is not clear what role religion plays in this relationship. The 2013 Chinese General Social Survey was used to examine the moderation role of religious identity and religious practice in this correlation. The STATA 15.1 and PROCESS macro for SPSS (Model 2) was employed. This research confirms that religion has a moderating role in the correlation between traditional media usage and moral evaluation. Specifically, religious identity, no matter whether it is polytheistic or monotheistic, will strengthen the correlation between traditional media usage and moral evaluation. However, religious practice will weaken the correlation between traditional media usage and moral evaluation, except the religious practice of monotheism in China. Furthermore, our findings prove that religion is an important situational factor in the correlation between traditional media usage and moral evaluation. We should take religious identity and religious practice as independent factors to conduct a richer study in the future. Most importantly, our findings further confirm that the rationalization of society does not necessarily lead to the secularization of religion.
Machine Learning Approaches for Auto Insurance Big Data
Authors: Hanafy Mohamed , Ming Ruixing
Published: February 2021

The growing trend in the number and severity of auto insurance claims creates a need for new methods to efficiently handle these claims. Machine learning (ML) is one of the methods that solves this problem. As car insurers aim to improve their customer service, these companies have started adopting and applying ML to enhance the interpretation and comprehension of their data for efficiency, thus improving their customer service through a better understanding of their needs. This study considers how automotive insurance providers incorporate machinery learning in their company, and explores how ML models can apply to insurance big data. We utilize various ML methods, such as logistic regression, XGBoost, random forest, decision trees, naïve Bayes, and K-NN, to predict claim occurrence. Furthermore, we evaluate and compare these models’ performances. The results showed that RF is better than other methods with the accuracy, kappa, and AUC values of 0.8677, 0.7117, and 0.840, respectively.