bluuebunny/crossref_metadata_2025 huggingface dataset:
Oncopreventive and Oncotherapeutic Potential of Licorice Chalcone
Compounds: Molecular Insights
Authors: Wang Yushu , Xia Wenxin , Tao Mengxin , Fu Xueyan
Published: August 2022

Background:

Licorice is an important traditional Chinese medicine commonly used in
clinical practice and contains more than 300 flavonoids. Chalcone is one of the main types of flavonoids
with a wide range of biological functions and pharmacological activities. In the anticancer
research, chalcone compounds have shown excellent performance.

Objective:

This review aims to summarize the biosynthetic pathway and pharmacokinetics of chalcone
from licorice and provide evidence for the anticancer effects of chalcone and the underlying
mechanisms involved.

Methods:

For this review, the following databases were consulted: the PubMed Database
(https://pubmed.ncbi.nlm.nih.gov), Chinese National Knowledge Infrastructure (http://
www.cnki.net), National Science and Technology Library (http://www.nstl.gov.cn/), Wanfang Data
(http://www.wanfangdata.com.cn/), and the Web of Science Database (http://
apps.webofknowledge.com/).

Results:

To date, about 56 chalcones have been isolated and identified from licorice, 14 of which
have antitumor effects. These chalcones have a wide range of biological activities and can inhibit
the viability, proliferation, and migration of cancer cells by blocking the cancer cell cycle, thus inducing
apoptosis and autophagy. However, the molecular mechanism of the anticancer effects of
chalcone is not fully understood.

Conclusion:

In this paper, the molecular mechanism of chalcone regulating different types of cancer
is reviewed in detail from the biosynthetic pathway. This comprehensive review article summarizes
the biosynthetic pathway and pharmacokinetics of chalcone from the traditional Chinese medicine
licorice and provides evidence for the potential anticancer effects of chalcone and the respective
mechanisms of action. This paper also provides a basis for structural modification, biosynthesis, and
new drug development of chalcone compounds in Glycyrrhiza uralensis.
Advances in Metal-organic Frameworks (MOFs) based Biosensors for
Diagnosis: An Update
Authors: Ashraf Ghazala , Ahmad Tauqir , Ahmed Muhammad Zeeshan , Murtaza  , Rasmi Yousef
Published: August 2022

Metal-organic frameworks (MOFs) have significant advantages over other candidate classes of chemo-sensory materials owing to their extraordinary structural tunability and character-istics. MOF-based biosensing is a simple and convenient method for identifying various species. Biomarkers are molecular or cellular processes that link environmental exposure to a health out-come. Biomarkers are important in understanding the links between environmental chemical expo-sure and the development of chronic diseases, as well as in identifying disease-prone subgroups. Until now, several species, including nanoparticles (NPs) and their nanocomposites, small mole-cules, and unique complex systems, have been used for the chemical sensing of biomarkers. Follow-ing the overview of the field, we discussed the various fabrication methods for MOFs development in this review. We provide a thorough overview of the previous five years of progress to broaden the scope of analytes for future research. Several enzymatic and non-enzymatic sensors are offered, together with a mandatory measuring method that includes detection range and dynamic range. In addition, we reviewed the comparison of enzymatic and non-enzymatic biosensors, inventive edges, and the difficulties that need to be solved. This work might open up new possibilities for material production, sensor development, medical diagnostics, and other sensing fields.
Prediction and Experimental Evaluation of the hERG Blocking Potential
of Drugs Showing Clinical Signs of Cardiotoxicity
Authors: Slavov Svetoslav , Zhao Jinghua , Huang Ruili , Xia Menghang , Beger Richard
Published: August 2022

Background:

A large scale experimental validation conducted at the National Center for Advancing
Translational Sciences (NCATS/NIH, USA) confirmed the predictions of our 3D-SDAR model
of hERG blockage and phospholipidosis induction. It was demonstrated that both hERG blockage and
phospholipidosis induction are driven by a common three-center toxicophore composed of two aromatic
rings and an amino group. This work extends our earlier efforts by predicting the hERG blocking potential
of pharmaceuticals from two additional datasets: i) one comprised of 106 drugs with reported clinical
signs of cardiotoxicity from the AZCERT database and ii) a dataset of 54 FDA-approved tyrosine kinase
inhibitors (TKIs).

Methods:

A bagging-like 3D-SDAR algorithm aggregating predictions from 100 randomized models was
used to predict the hERG blocking potential of all 160 drugs. All 106 drugs from the AZCERT dataset
were further evaluated for their hERG inhibition at NCATS using a thallium flux assay.

Results:

Comparison of the predicted hERG class against the results of the thallium flux qHTS assay
resulted in an overall predictive accuracy of 0.736 and the area under the ROC curve of 0.780. Factors
such as the generation of false negatives by the thallium flux assay, proximity to the cut-off, use of conformations
that may differ from the biologically relevant ones, and the lack of structurally similar compounds
in the modeling set could explain the somewhat reduced predictive performance compared to that
of the original model. The original 3D-SDAR model was also used to evaluate the TKIs ability to block
hERG. Comparing our predictions to class assignments based on IC50 values with a 30 μM cut-off, an
accuracy of 0.850, sensitivity of 0.906, and specificity of 0.625 were achieved.

Conclusion:

3D-SDAR provides a reliable platform for the prediction of hERG blockage. Particular attention
should be paid to all investigational new drugs containing our three-center hERG toxicophore,
especially those having highly flexible molecules. Particular scrutiny should be given to the tyrosine kinase
inhibitors, which represent a therapeutic class possessing all structural characteristics previously
associated with an increased potential to block hERG.
Virtual Screening of Native Variants of Focal Adhesion Kinase - A QSAR,
Molecular Docking, and Dynamic Simulation Study
Authors: Karunakar Prashantha , K.S Kiran , Prasad Suchitra Krishna , Prabhu Praneetha , Chandramohan Vivek
Published: August 2022

Objective:

Focal adhesion kinase (FAK) is a cytosolic tyrosine kinase that controls integrin and
growth factor signaling pathways. FAK is a promising therapeutic target for cellular adhesion-related
disorders, such as cancer.

Methods:

In this study, in silico techniques like quantitative structure-activity relationship (QSAR), Molecular
Docking, and Dynamic Simulation were used to study the interactions between small molecules
and FAK.

Results:

The constructed QSAR model showed good statistical parameters (Q2=0.8040 and R2=0.8499),
indicating that it is stable and reliable. Based on this model, several new compounds were screened from
small molecule databases and their inhibitory activities were validated by molecular docking and molecular
dynamics simulation. Pharmacokinetic parameters were checked using in silico ADME testing.

Conclusion:

Results show that the protein-ligand complexes are stable during the simulation and are considered
potential inhibitors of Focal Adhesion Kinase.
Lemon Nutraceuticals for Management of Metabolic Syndrome Disorders:
Recent Advances
Authors: Kehinde Bababode Adesegun , Rafiq Shafiya , Adekoya Adetokunbo
Published: August 2022

The modern industrial application of lemon is significantly associated with their juicy materials obtained from the pulpy region, leaving behind a remarkable mass of by-products which are often discarded as waste. Several studies have shown that materials obtained from all handling and processing operations have substantial biological benefits based on their concomitant phytochemistry. In addition, these materials have been found suitable as raw substrates for the syntheses and manufacturing of various food-based additives. This research succinctly delineates these concepts and offers a comprehensive framework of its etymology, rich history, and overall pomology. More importantly, recently studied underlying biochemical mechanisms for the actions of lemon and its by-products for metabolic disorders such as diabetes, cancer and hypertension are technically delineated. These materials have been appraised as natural sources for nutraceuticals studied to be potential alternatives to typical synthetic pharmaceutics.
Progesterone and Treatment for Preterm Birth: Past, Present and Future
Authors: Bracamontes Katherine , Garfield Robert
Published: August 2022

Preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality in the
United States and worldwide. Efforts to predict and delay preterm birth have been largely unsuccessful
thus far. This paper seeks to illuminate the history and relevant discoveries regarding the role of
progesterone in the prevention of PTB, which includes maintaining quiescence of the myometrium
and counteracting cervical ripening. We will review the outcomes and methodologies of recent clinical
trials, which have led to debate over the efficacy of progesterone in delaying PTB among at-risk
women. The aim of this paper is to explore the historical and scientific basis for progestin treatments
in the prevention of PTB, briefly discuss the results of recent clinical trials, and suggest direction for
future research.
Design, Synthesis, and Molecular Docking Study of Novel 3-Cyanopyridine
Derivatives for the Anti-Cancer Drug Target Survivin Protein
Authors: Shen Li-Qun , Wu Ai-Qun , Lu Jia-Hao , Lai Wu-Ji , Jiang Li-He , Lei Fu-Hou
Published: August 2022

Background:

Survivin is an important member of the antiapoptotic protein family and controls the
cell’s life cycle. Overexpression of survivin in tumor cells leads to inhibition of apoptosis, thus contributing
to cancer cell proliferation. The largest binding pocket in the survivin dimer was located in
the BIR domain. The key to the efficacy of 3-cyanopyridines was their surface interaction with the
survivin amino acid Ile74.

Method:

Through the optimization of the 3-cyanopyridine, 29 new compounds with a 3-
Cyanopyridine structure were designed, synthesized, and characterized by NMR, IR, and mass
spectrometry. The antitumor activity of the compounds in vitro was detected by the MTT method.

Results:

In vitro anti-tumor experiments showed that some compounds exhibited good anti-cancer
effects. The IC50 values of the compound 2-amino-6-(2,4-difluorophenyl)-4-(4-hydroxyphenyl) nicotinonitrile
(10n) against human liver cancer (Huh7), human glioma (U251), and human melanoma
(A375) cells were 5.9, 6.0 and 7.2 μM, respectively. The IC50 values of the compound 6-(2,4-difluorophenyl)-
4-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (9o) against Huh7,
U251 and A375 cells were 2.4, 17.5 and 7.2 μM, respectively, which were better than those of 10-
hydroxycamptothecin and 5-fluorouracil. Analysis of the results of molecular dynamics simulation
established that the BIR domain is the optimal binding site on the survivin protein, and the fingerprints
of the eight most active compounds and the molecular docking to the survivin protein are analyzed.

Conclusion:

3-Cyanopyridine is an excellent backbone for antitumor lead compounds, 10n and 9o,
as derivatives of 3-Cyanopyridine are excellent survivin protein-targeting inhibitors worthy of further
study. The key factor in inhibiting survivin protein through the action of amino acid Ile74.
Current Trends in Immuno-Oncology
Authors: Vanteddu Venkata Gangadhar , Sweta Bawari , Patel Tulsi Dipakbhai
Published: August 2022

Surgery, radiation, chemotherapy, and targeted therapy were the four basic kinds of
cancer treatment until recently. Immuno-oncology (IO), or the concept that cancer cells were
damaged by activating the body's immune system, has emerged and is explained as a unique and
crucial method for treating different cancers over the last decade. The US Food and Drug Administration
and the European Medicines Agency both approved this newly recognized way of
treating cancer in 2020. Within IO, different therapeutic classes have arisen, which are the subject
of this article. Immune checkpoint inhibitors are currently the most well-known therapeutic
class of immuno-oncology medications due to their amazing ability to show efficacy in a variety
of tumor types. Biomarkers were tested for different tumors like gastrointestinal cancer, whole
Head, lower and upper part Neck cancer, and also cervical cancer by programmed death-ligand 1
(PD-L1) check point and their targets and are currently being utilized prior to treatment by using
Pembrolizumab. However, the significance of PD-L1 expression for immune check point reticence
therapy in other/different onco-cancer types remains unclear. Homogenized immuneoncology
drugs with regular therapy have been recently studied and clinical efficacy outcomes
have shown to be significantly improved. While IO agents are fast transforming the marketed
treatment for cancer patients, there are still a number of obstacles to overcome in terms of associating
their adverse effects and confirming those different healthcare systems, such as financing
these expensive therapies. In addition to cancer vaccines and chimeric antigen receptor T-cell
treatments, other IO drugs are in pipeline containing chimeric antigen receptor T-cell therapies;
earlier ones have their own set of toxicities and high cost related challenges.
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic
and Therapeutic Targets
Authors: Vakili Omid , Asili Pooria , Babaei Zeinab , Mirahmad Maryam , Keshavarzmotamed Atoosa , Asemi Zatollah , Mafi Alireza
Published: August 2022

Background:

Circular RNAs (circRNAs), as covalently closed single-stranded noncoding
RNA molecules, have been recently identified to involve in several biological processes, principally
through targeting microRNAs. Among various neurodegenerative diseases (NDs), accumulating evidence
has proposed key roles for circRNAs in the pathogenesis of Alzheimer’s disease (AD); although
the exact relationship between these RNA molecules and AD progression is not clear, they have been
believed to mostly act as miRNA sponges or gene transcription modulators through the correlating
with multiple proteins, involved in the accumulation of Amyloid β (Aβ) peptides, as well as tau protein,
as AD’s pathological hallmark. More interestingly, circRNAs have also been reported to play
diagnostic and therapeutic roles during the AD progression.

Objective:

The literature review indicated that circRNAs could essentially contribute to the onset and
development of AD. Thus, in the current review, the circRNAs’ biogenesis and functions are
addressed at first, and then the interplay between particular circRNAs and AD is comprehensively
discussed. Eventually, the diagnostic and therapeutic significance of these noncoding RNAs is briefly
highlighted.

Results:

A large number of circRNAs are expressed in the brain. Thereby, these RNA molecules are
noticed as potential regulators of neural functions in healthy circumstances, as well as in neurological
disorders. Moreover, circRNAs have also been reported to have potential diagnostic and therapeutic
capacities in relation to AD, the most prevalent ND.

Conclusion:

CircRNAs have been shown to act as sponges for miRNAs, thereby regulating the function
of related miRNAs, including oxidative stress, reduction of neuroinflammation, and the formation
and metabolism of Aβ, all of which developed in AD. CircRNAs have also been proposed as
biomarkers that have potential diagnostic capacities in AD. Despite these characteristics, the use of
circRNAs as therapeutic targets and promising diagnostic biomarkers will require further investigation
and characterization of the function of these RNA molecules in AD.
The Potential Role of Naringin and Naringenin as Nutraceuticals Against
Metabolic Syndrome
Authors: Massaro Luca , Raguzzini Anna , Aiello Paola , Valencia Débora Villaño
Published: August 2022

Metabolic syndrome, an increasing problem in western society, is a cluster of conditions
that affect cardiovascular health, lipid and glucose management, increasing the risk of heart diseases,
stroke and diabetes. Bioactive flavonoids are a great resource of compounds with proven antiinflammatory
activities. Naringin, a natural flavanone found in citrus fruits, and its aglycone have
demonstrated to ameliorate obesity, dyslipidemia, and insulin resistance in animal models. The principal
mechanisms by which these flavonoids exert their action involve AMPK and PPARα up-regulation
and the down-regulation of genes involved in lipid metabolism. Although different studies
have been carried out to define the pharmacological effects of these flavonoids, their therapeutic use
is still limited.
The Influence of TNF-α, IL-6, TGF-β1, IFN-γ, IL-10 Polymorphisms on Predisposition
to Diabetes Mellitus among Jordanian Patients
Authors: Khdair Sawsan I. , Al-Naimat Ola S. , Jarrar Wassan , Al-Qerem Walid , Khudeir Feras A.
Published: August 2022

Background:

Diabetes mellitus is a long-term disorder with high prevalence globally. It can be classified into two types: Type 1 diabetes and Type 2 diabetes mellitus. Diabetes mellitus is considered a multifactorial disorder in which genetic factors such as cytokines play a major role. Cytokines play a role is immune modulation and are associated with the development of diabetes mellitus. Single nucleotide polymorphisms in cytokines were studied extensively in different populations to determine their association with predisposition to diabetes mellitus. Objective: The aim of this study was to estimate the frequency of single nucleotide polymorphisms in the cytokine genes TNF-α, TGF-β, IL-6, IL-10, and INF-γ in 102 Jordanian diabetes mellitus patients in comparison to 50 controls and their association to diabetes mellitus susceptibility.

Objective:

The aim of this study was to estimate the frequency of single nucleotide polymorphisms in the cytokine genes TNF-α, TGF-β, IL-6, IL-10, and INF-γ in 102 Jordanian diabetes mellitus patients in comparison to 50 controls and their association to diabetes mellitus susceptibility.

Methods:

Analysis was performed using the highly specific polymerase chain reaction-sequence specific primers methodology

Results:

Our findings showed that the IL-10-1082 G/G genotype (P=0.02) and the TGF-β1 codon 25*G allele (P<0.01) may be considered risk factors for type 2 diabetes mellitus. In addition, the IFN- γ -874*A allele (P=0.04) seems to increase the predisposition to type 1 diabetes.

Conclusion:

Our study showed that the IL-10-1082 G/G genotype and TGF-β1 codon 25*G allele are associated with type 2 diabetes mellitus while the IFN- γ -874*A allele is associated with type 1 diabetes. Our findings may help in the early detection of diabetes mellitus which would in turn help in undergoing the needed preventative measures to delay the onset of diabetes mellitus
Effect of SGLT2 Inhibitors and Metformin on Inflammatory and Prognostic
Biomarkers in Type 2 Diabetes Patients
Authors: Cao Yang , Liang Ning , Liu Ting , Fang Jingai , Zhang Xiaodong
Published: August 2022

Objective:

To assess the combined effect of Sodium-Glucose Transporter 2 Inhibitors (SGLT2i) and metformin treatment on inflammatory and prognostic biomarkers in patients with T2DM.

Methods:

Using the search terms “Sodium-Glucose Transporter 2 Inhibitors,” “Diabetes Mellitus, Type 2,” and “randomized controlled trial,” we screened the literature on PubMed, Cochrane Library, Embase, and Web of Science according to the inclusion and exclusion criteria. The studies selected were grouped to determine the combined effect of SGLT2i and metformin on inflammatory markers in patients with T2DM. Results were expressed using continuous variables, combined into weighted mean differences (WMD) and 95% confidence intervals (CI). The study was registered under the PROSPERO number CRD42022296480.

Results:

Meta-analysis showed that, compared with the control and metformin treatment groups, the SGLT2i coupled with metformin group was more effective in reducing C-reactive protein (CRP) (WMD, −0.185, 95% CI, −0.330 to −0.040, P < 0.05), tumor necrosis factor (TNF-α) (WMD, −0.628, 95% CI, −1.046 to −0.210, P < 0.05), uric acid (WMD, −0.653, 95% CI, −0.734 to −0.572, P < 0.05), leptin (WMD, −3.663, 95% CI, −4.812 to −2.515, P < 0.05), glycated hemoglobin (HbA1c) (WMD = −0.172, 95% CI, −0.255 to −0.089, P < 0.05)，and estimated glomerular filtration rate (eGFR)(WMD = 0.978, 95% CI (0.027, 1.928), P = 0.044). In parallel, we performed a Trial Sequential Analysis (TSA) of and the results showed reliable conclusions.

Conclusions:

SGLT2i combined with metformin reduced inflammation levels and significantly improved glycemic control and prognosis in patients with T2DM.
Transepithelial Corneal Cross-linking with Supplemental Oxygen in Keratoconus Treatment - Corneal Stromal Demarcation Line and Safety
Authors: Choo Jessica Qian Hui , Lim Li
Published: August 2022

Purpose:

To evaluate the corneal stromal demarcation line and safety of transepithelial corneal cross-linking (CXL) with supplemental oxygen in progressive keratoconus treatment.

Methods:

This is a retrospective review of 25 patients with progressive keratoconus who underwent epithelial-on CXL with supplemental oxygen from December 2019 to February 2022. Outcomes measured include corneal stromal demarcation line depth, volume of cornea treated, endothelial cell count, best-corrected visual acuity, keratometric parameters and post-treatment adverse events.

Results:

25 eyes of 25 patients were included and mean age was 28.3 years. Mean follow-up period was 11.5 ± 1.39 months. Pre-operatively, mean ± standard deviation (SD) of K1, K2, Kmax and minimal corneal thickness were 45.9D ± 3.79D, 50.2D ± 4.83D, 57.5D ± 6.98D and 482.3um ± 36.8um respectively. There is no significant difference between pre and post-treatment corneal topographic parameters. There was improvement in BCVA post-treatment. The mean post-treatment corneal stromal demarcation line depth was 367.3 ± 89.8um. The volume of treated cornea including the central corneal epithelial thickness was 73.3 ± 4.39%. There was no reduction in endothelial cell count (ECC) post-procedure (pre-treatment mean ECC±SD: 2695.4 ± 224.5 cells/mm2, post-treatment ECC 2730.1 ± 252.0 cells/mm2, p-value = 0.33). Post-treatment corneal haze was mild and seen in 8 patients postoperatively. One patient developed a non-visual axis involving stromal infiltrate that resolved with topical broad-spectrum anti-microbials.

Conclusion:

Trans-epithelial CXL with supplemental oxygen for keratoconus treatment achieved comparable corneal stromal demarcation line depth comparable to that of conventional epithelial-off corneal cross-linking and had a similar safety profile.
The Rights of Unborn and Newborn Babies in Jordanian Arab Culture: Implications for Practice
Authors: Bawadi Hala , Al-Hamdan Zaid M. , Farhat Eshraq , Aldasoqi Khadeejeh Yousef , Alhammdan Mohammad , Jabaiti Samir
Published: August 2022

Background:

Traditional patterns relating to how to handle the provision of culturally competent care for refugees are often challenging. Addressing the unique religious and cultural beliefs and norms of refugee parents during the childbirth process will alleviate their anxiety and feelings of alienation with respect to healthcare systems.

Objectives:

This paper aims to understand the meaning of Jordanian women’s beliefs and practices related to their foetuses and newborns and to facilitate the recognition by Western healthcare providers of these practices among immigrants and refugees.

Methods:

An interpretive phenomenological study was used to conduct an individual in-depth semi-structured interview with nine women.

Results:

Eight superordinate themes were identified: couple in legitimate relationship before conception, rejection of abortion, accepting the gender of the baby, guaranteeing that ‘Allah’ is the first word heard, rubbing the newborn’s palate with a date, choosing a meaningful name, ensuring circumcision for boys and showing gratitude to Allah.

Conclusion:

The attitudes of Jordanian women towards newborns’ rights and care are greatly influenced by their cultural and religious backgrounds. Capturing these attitudes and needs can inform the development of health education strategies and information resources. To enhance Muslim women’s engagement in maternal newborn health services, maternity staff should endeavour to create a trusting relationship with the childbearing women, which values their social, cultural and spiritual needs.
Calprotectin as a Serodiagnostic Marker for Bacterial Sepsis
Authors: Rezaei Faranak , Bakhshiani Zahra , Fouladi Saloomeh
Published: August 2022

Introduction:

Since sepsis is a major global health problem, a rapid and correct diagnosis and the initiation of therapy are essential to improve the patient consequences. This study aimed to assess the serum levels of calprotectin and a more widely used sepsis biomarker in the patients with bacterial sepsis (BS).

Method:

Subjects were classified into BS group with the patients who met the sepsis criteria at the beginning of the study and the control group. We investigated the concentrations of biomarkers in 300 blood samples collected at admission from all patients hospitalized in the Fatemeh Al-Zahra Hospital, Najafabad, Isfahan in April 2019 and April 2020.

Results:

The microbial etiology in the BS group was confirmed in 35 patients (100%). The most frequently cultivated pathogens were Escherichia coli (n=11). The serum concentrations of calprotectin and CRP were significantly higher in the patients with BS (n= 35) than in the healthy controls (n= 20).

Conclusion:

Our results suggest that the serum level of calprotectin could have the substantial added value to manage BS which is a reliable biomarker of BS.
A Brief Overview of Invasive Fungal Infections in Immunocompromised Individuals
Authors: Pisote Deepak Kakasaheb , Menon Gowtham , Choure Rohit Lahurao
Published: August 2022

Fungí is eukaryotic microorganisms that may spread and cause illness on the skin, subcutaneously,
and systemically. These infections can be invasive and difficult to identify at times. A patient
with a damaged immune system is more likely to get a fungal infection. Long-term chemotherapy,
organ transplantation, corticosteroid usage, or multidrug treatment all result in immunocompromised
people. Why do immunocompromised individuals need to be treated? The answer of this
query is that the immune system serves as an army for the human body, if it fails to protect it, foreign
particles such as bacteria, fungus, and viruses assault the body, causing the patient to become
immunocompromised. Candidiasis, aspergillosis, mucormycosis, and cryptococcal meningitis are
the most frequent invasive fungal diseases encountered in immunocompromised people. Patients afflicted
with invasive fungal infections have a significant death rate. As the number of immunocompromised
patients rises, so does the number of fungal infections. In this article, we took a quick look
at a few invasive fungal infections such as candidiasis, aspergillosis, and mucormycosis.
Promising Tactics with Certain Probiotics for the Treatment of Nephropathy in Hematopoietic Stem Cell Transplantation
Authors:   Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan, Taniguchi Kurumi , Sawamura Haruka ,   Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan, Ikeda Yuka ,   Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan, Tsuji Ai ,   Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan, Matsuda Satoru ,   Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan
Published: August 2022

Hematopoietic stem cell transplantation (HSCT) is a standard form of cellular therapy for patients suffering from malignant hematological diseases. However, graft-versus-host disease (GVHD) is a very serious complication and a major cause of morbidity and mortality after allogeneic HSCT. Calcineurin inhibitors, such as cyclosporine, are widely used to enhance the survival of patients who have undergone HSCT. Unfortunately, both GVHD and cyclosporine occasionally cause nephropathy. Several studies have shown that the gut-kidney axis is associated with nephropathy. Dysbiosis of the gut microbiota might aggravate renal damage by increasing systemic micro-inflammation, suggesting that diet might affect the risk of GVHD. Here, we summarized the recent findings regarding the association between the alteration of gut microbiota and nephrotoxicity. The results suggested that treatment with certain probiotics benefits the symbiosis in the gut-kidney axis and makes HSCT safer.
"Religious pluralism In Islamic Thought "
Authors: fatah aruzary nasih
Published: August 2022

"Summary Religious pluralism in its Western sense is an emergency solution by Western intellectuals to the lack of principles of religious and sectarian coexistence from the perspective of their religions. However, the term religious pluralism according to the Western perspective, which believes in the relativity of truth; He claims that all religions have some truth; Makes existing religions mere human opinions; It cuts off its connection from the absolute right, but removes the dress of divine revelation from it! Islam is a religion that believes in diversity and religious pluralism, by a special definition. so that religions are accepted as they are; And its texts show how to deal properly with all the people of religions Between both rights and duties, they provide both the rights and duties of the people of religions, so that the result is for the people of religions, so that the result Peaceful coexistence in reality, as well as convergence and harmony among all segments of society. This recognition of diversity through Islamic thought has made pluralism a real source of peaceful coexistence, rather than religious conflicts and sectarian intolerances. It has also made it a way of real creativity and production. "
Effectiveness of a Web-Based Intervention to Prevent Anxiety in the Children of Parents With Anxiety: Protocol for a Randomized Controlled Trial
Authors: Dunn Abigail , Alvarez James , Arbon Amy , Bremner Stephen , Elsby-Pearson Chloe , Emsley Richard , Jones Christopher , Lawrence Peter , Lester Kathryn J , Majdandžić Mirjana , Morson Natalie , Perry Nicky , Simner Julia , Thomson Abigail , Cartwright-Hatton Sam
Published: August 2022

Background

Anxiety is the most common childhood mental health condition and is associated with impaired child outcomes, including increased risk of mental health difficulties in adulthood. Anxiety runs in families: when a parent has anxiety, their child has a 50% higher chance of developing it themselves. Environmental factors are predominant in the intergenerational transmission of anxiety and, of these, parenting processes play a major role. Interventions that target parents to support them to limit the impact of any anxiogenic parenting behaviors are associated with reduced anxiety in their children. A brief UK-based group intervention delivered to parents within the UK National Health Service led to a 16% reduction in children meeting the criteria for an anxiety disorder. However, this intervention is not widely accessible. To widen access, a 9-module web-based version of this intervention has been developed. This course comprises psychoeducation and home practice delivered through text, video, animations, and practice tasks.

Objective

This study seeks to evaluate the feasibility of delivering this web-based intervention and assess its effectiveness in reducing child anxiety symptoms.

Methods

 This is the protocol for a randomized controlled trial (RCT) of a community sample of 1754 parents with self-identified high levels of anxiety with a child aged 2-11 years. Parents in the intervention arm will receive access to the web-based course, which they undertake at a self-determined rate. The control arm receives no intervention. Follow-up data collection is at months 6 and months 9-21. Intention-to-treat analysis will be conducted on outcomes including child anxiety, child mental health symptoms, and well-being; parental anxiety and well-being; and parenting behaviors.

Results

Funding was received in April 2020, and recruitment started in February 2021 and is projected to end in October 2022. A total of 1350 participants have been recruited as of May 2022.

Conclusions

The results of this RCT will provide evidence on the utility of a web-based course in preventing intergenerational transmission of anxiety and increase the understanding of familial anxiety.

Trial Registration

ClinicalTrials.gov NCT04755933; https://clinicaltrials.gov/ct2/show/NCT04755933

International Registered Report Identifier (IRRID)

DERR1-10.2196/40707
Shift in Microbial Community Structure with Temperature in Deulajhari Hot Spring Cluster, Odisha, India
Authors: Singh Archana , Subudhi Enketeswara , Sahoo Rajesh Kumar , Gaur Mahendra , Dixit Sangita
Published: August 2022

Hot springs are the reservoirs of novel hyperthermophilic and often mesophilic bacteria that provide information about the prevailing community structure. Here we analyzed the metagenome profile based 16S rRNA amplicon sequencing of the three different springs from Deulajhari hot spring cluster, S1, S2 and S3, having a range of temperature (43°C to 65°C), pH (7.14 – 8.10) and variation in N, P, K, TOC, Salinity, COD and TDS. These thermal spring clusters are covered with the dense vegetation of Pandanus and continuously enriched by plant leaf debris, thus resulting in a high amount of total organic carbon (TOC). The number of phyla varied among the springs: 20 in S1 (43°C), 18 in S2 (55°C) and 24 in S3 (65°C) from the 16S rRNA data. Out of the reported phyla in each spring, the most abundant were Chloroflexi, Proteobacteria, Chlorobi and Acidobacteria, which correlated with the temperature gradient. Various metabolic pathways such as ABC transporters, Two-component system, Purine metabolism were most abundantly present in the S2 sample compared to the other two. The CCA analysis revealed the correlation between physiochemical parameters and their functional annotation. The present study establishes the relation between the physiological parameters and the structural distribution of microbiota along the temperature gradient.
Two in One Electronic Energy and Water Saving Device
Authors: Aggarwal Himanish , Kaur Jaspal
Published: August 2022

Abstract: Friends you must be knowing that each drop of water is essential for our life. As you know that the level of water is falling down day by day. Our teacher as well as friends advised to use water according to need, to wash the car we should use less water use bucket of water instead of using shower while bathing. These days we use R.O systems in our homes instead of throwing away the waste water we must use it for watering the plants. Friends as you know that there are many type of air coolers in the market. They are cheaper than Air conditioners and gives clean air. With the help of this device our Ozone layer does not get affected. And our government also asked the citizens to use electricity carefully. To solve this problem, I have prepared this project Two in One Electronic - Energy and Water saving device
Instrumentos para avaliação das competências de liderança em enfermagem: Revisão de literatura
Authors: Facião Beatriz Helen , Aroni Patricia , Haddad Rodrigues Mariana , Malaquias Tatiana da Silva Melo , Barreto Maynara Fernanda Carvalho , Rossaneis Mariana Ângela , Haddad Maria do Carmo Fernandez Lourenço
Published: August 2022

Introdução: A difusão tecnológica do mercado de trabalho exige o desenvolvimento de habilidades e competências diferenciadas dos enfermeiros, para que estes possam assumir novas responsabilidades gerenciais e organizacionais. Objetivo: Identificar na literatura instrumentos para avaliação das competências necessárias à liderança em enfermagem. Método: Revisão integrativa da literatura, a qual utilizou as bases Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL) e Scopus. Resultados: Foram selecionados 10 estudos nesta revisão os quais identificaram os seguintes instrumentos: Ambulance Nurse Competence (ANC) scale; Leadership Practives Inventory (LPI); Clinical Leadership Needs Analysis (CLeeNA) Instrument; Cotter Preceptor Selection Instrument (CPSI); Performace Evaluation Tool; Leadership and Management Inventory; Advanced Practice Nursing Competency Assessment Instrument (APNCAI); Kuopio University Hospital Transformational Leadership Scale (KUHTLS); Multisource Feedback (MSF) e um instrumento constituído por construtos para capacitar sobre os comportamentos de comunicação dos líderes em enfermagem, cujo título não foi informado pelos autores. Conclusão: Esta revisão integrativa da literatura identificou dez instrumentos para avaliar as competências essenciais à liderança em enfermagem. A comunicação foi identificada como uma das principais competências alinhada ao papel de gestor. A tomada de decisão, a habilidade social, o gerenciamento da equipe, a informação atualizada e a gestão estratégica e financeira são elementos de suma importância no exercício gerencial e assistencial do enfermeiro, para que se estabeleça uma relação harmônica entre os líderes e os liderados no processo de trabalho.
The mediating effect of social competence on the relationship between decision making ability and happiness in young children
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Ji Young , Kim Yong Sook
Published: August 2022

Objectives This study explored of decision making ability on happiness and mediating effects of social competence on the relationship between decision making ability and happiness. Methods To achieve this goal, a survey was conducted on 238 young children enrolled in private kindergartens in the J area. Collected data were analyzed by descriptive statistics, Pearson’s correlation analysis, multiple regression analysis and sobel test using the computer program, SPSS/PC 22.0. Results The results of this study were as follows. First, there were significant positive relationships among decision making ability, social competence and happiness. Second, decision making ability was an important factor to predict happiness of young children, and social competence had mediating effects on the relationship between decision making ability and happiness. Conclusions In conclusion, it suggests that decision making ability and social competence should be supported in a balanced manner to increase infant happiness in order to support COVID-19 blue and improve the quality of education.
Coaches Specialized Content Knowledge Change through Content Knowledge of Rhythmic Gymnastics Workshop
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kwak Ju-hyun
Published: August 2022

Objectives Ward (2009) emphasized the content knowledge of leaders, coaches, and teachers who teach students and revealed the correlation with student performance. Purpose of this study is to investigate the changes in SCK and performance of rhythmic gymnastics leaders based on the World Gymnastics Federation manual. Methods Participants were tennis coaches(n=14), athletes(n=28). The SCK data were content map(instructional tasks)(Ward, et al., 2017). The content map was used to measure the coach SCK, and the athletes performance as scored by the judges. Data were analyzed using the Shapiro Wilk test, nonparametric statistics Mann Whitney U verification, and the SPSS statistical program ANOVA were used for correlation analysis. Results The results of this study showed that (1) coaches who participated in the workshop had high SCK. (2) was a difference between the SCK and the performance of athletes of the coaches who participated in the workshop before and after the workshop. (3) was a relationship between coaches SCK and athletes performance. Conclusions Specialized content knowledge is the core of content knowledge necessary for coaches for the performance of athletes in the sports field. Therefore, education and workshops for preliminary and incumbent leaders based on expertise should be actively conducted.
The Relationship among Retirement Anxiety, Career Decision-Making Self-Efficacy and Career Preparation Behavior of College Athletes
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Chung Jae-Eun
Published: August 2022

Objectives The purposes of this study were to investigate the structural relationship model of retirement anxiety, career decision-making self-efficacy and career preparation behavior of athletes in college. Methods The participants of this study consisted using of 415 athletes who were more than 18 years old with more than 3 years experience of competition. They were assessed by retirement anxiety scale, career decision-making self-efficacy scale and career preparation behavior scale. The evaluation questionnaires were modified to reflect the circumstances in Korea and underwent a validity test prior to translation. The data were conducted by descriptive statistics, confirmatory factor analysis, reliability analysis, correlation analysis, and structure equation modelling. Results First, retirement anxiety had no a influence on career decision-making self-efficacy. Second, retirement anxiety had a positive influence on career preparation behavior. Third, career decision-making self-efficacy had a positively influence on career preparation behavior. Conclusions The result of this study suggests the need of developing programs and providing necessary support aimed at improving college athletes' decision-making self-efficacy and career preparation behavior through career counseling and education.
CDDO-Me'nin Meme Kanseri Hücrelerindeki Etkilerinin Tamoxifen ve Docetaxel ile Karşılaştırılması
Authors: ABUŞOĞLU Gülsüm , KOÇAK Cengiz , KOÇAK Fatma , OZTURK Bahadir , VATANSEV Hüsamettin
Published: August 2022

Amaç: Oleanolik asitten türetilen sentetik triterpenoidlerin, güçlü antiproliferatif ve antitümörojenik aktiviteye sahip oldukları bilinmektedir. Bu çalışmada, bir triterpenoid olan CDDO-Me'nin insan meme kanseri hücre hatları üzerindeki sitotoksik etkilerini, meme kanserinin rutin tedavisinde kullanılan Tamoxifen ve Docetaxel ile karşılaştırarak araştırmaktır. Materyal Metod: CDDO-Me, Docetaxel veTamoxifen’in sitotoksik etkilerini incelemek için meme kanseri hücreleri olarak MCF-7 ve MDA MB-231 hücre hatları tercih edildi. Her bir ilacın çeşitli dozları hücrelere uygulanarak sitotoksik etkileri xCELLigence cihazı ile belirlendi ve ilaçların IC50 değerleri belirlendi. IC50 dozlarıyla muamele edilen hücrelerden hücre blokları hazırlanarak, histolojik ve immünohistokimyasal boyama ile proliferasyon indeksi Ki-67 ve Cyclin D1, antiapoptotik Bcl-2 ve proapoptotik Bax protein ekspresyonları skorlandı. Bulgular: CDDO-Me, Docetaxel veTamoxifen her iki hücre hattında hücre canlılığını istatistiksel olarak önemli bir şekilde inhibe etti. CDDO-Me'nin Tamoxifen ve Docetaxel ile etkileri moleküler düzeyde karşılaştırıldığında, her iki hücre hattında da apopitoz yolağı açısından CDDO-Me’nin, Tamoxifen ve Docetaxel’e göre istatistiksel olarak daha etkili olduğu (p<0.001) sonucuna varıldı. Hücre döngüsü açısından ise MCF-7 hücrelerinde CDDO-Me'nin Tamoxifen ile istatistiksel olarak benzer etkiler gösterdiği ve Docetaxel’in bu hücre hattında istatistiksel olarak daha etkin olduğu (p<0.001) ve MDA MB-231 hücrelerinde ise CDDO-Me'nin Docetaxel ile istatistiksel olarak benzer etkiler gösterdiği ve Tamoxifenin bu hücre hattında istatistiksel olarak daha etkin olduğu gözlemlendi (p<0.001). Sonuç: CDDO-Me'nin antiproliferatif ve apopitoz indükleyici etkileri, rutin meme kanseri tedavisinde kullanılan Tamoxifen ve Docetaxel'in etkilerine göre her iki meme kanseri tipinde farklılık gösterse de, CDDO-Me, meme kanseri tedavisinde alternatif bir kemoterapötik ajan olabilir. Ayrıca bu çalışmanın sonuçları gelecekte yapılacak in vivo çalışmalara yol gösterici olabilir.
Farklı Konsantrasyonlarda Glikolik Asit Kullanımının Kök Kanal Dolgu Materyallerinin Bağlanma Dayanımı Üzerine Etkisi
Authors: DEMİRBAŞ Muhammed , MADEN Murat , ORHAN Hikmet
Published: August 2022

Amaç: Bu çalışmanın amacı farklı final irrigasyon prosedürlerinin MTA Fillapex kök kanal dolgu patının bağlanma dayanımı üzerine olan etkisini araştırmaktır.Gereç ve Yöntem: Bu çalışmada 98 adet çürüksüz insan alt premolar dişi kullanıldı. Dişlerin koronal bölümleri çalışma uzunlukları 12 mm olacak şekilde uzaklaştırıldı. Kök kanalları ProTaper Next ile genişletildi. Örnekler rastgele 7 gruba dağıtıldı ve farklı final irrigasyon prosedürleri (Grup 1:EDTA, Grup 2:%10 glikolik asit, Grup 3:%17 glikolik asit, Grup 4:EDTA+CHX, Grup 5:%10 glikolik asit+CHX, Grup 6:%17 glikolik asit+CHX ve Grup 7:Distile su) uygulandı. Kök kanalları MTA Fillapex ve guta perka ile dolduruldu. Örneklerden, apikal konstriksiyondan itibaren 4 ve 9 mm mesafede olacak şekilde kesitler alındı. Push-out testi yapılarak kesitlerdeki kök kanal dolgusunun bağlanma dayanımı değerleri hesaplandı. Veriler Duncan ve T testleri kullanılarak istatistiksel olarak incelendi. Bulgular: Gruplar arasında yapılan değerlendirmede 4. ve 9. mm’den alınan her iki kesitte de; kök kanal dolgusunun en yüksek bağlanma dayanımı değerleri Grup 6’da, en düşük bağlanma dayanımı değerleri ise grup 7’de tespit edildi (p<0,05). Her iki kesitte de bağlanma dayanımı Grup 6>Grup 3>Grup 5≥Grup 2>Grup 4≥Grup 1>Grup 7 şeklinde tespit edildi. Grup içi değerlendirmede ise; bütün gruplarda 9. mm’den alınan kesitlerdeki kök kanal dolgusunun bağlanma dayanımı değerleri, 4. mm’den daha yüksek bulundu (p<0,05).Sonuç: MTA Fillapex kök kanal dolgu patının bağlanma dayanımı açısından; glikolik asit EDTA’dan daha yüksek değerler gösterdi. %17 glikolik asit ve CHX ile yapılan final irrigasyonu en yüksek bağlanma dayanımı değerlerini gösterdi.
A Comparison of the Postoperative Pain Relief and Clinical Local Anesthetic Efficacy of Levobupivacaine and Articaine for Impacted Lower Third Molar Removal
Authors: ERGÜDER Burak , AKKEMİK KIPÇAK Özlem , KÖYMEN Ramazan
Published: August 2022

Objective: A comparison of postoperative pain relief and clinical anesthetic efficacy of 2% articaine and 0.5% levobupivacaine in impacted third molar dental surgery. Material-Method: Fifty-three patients underwent the removal of symmetrically positioned lower third molars in 2 separate appointments under local anesthesia either with 2% articaine or 0.5% levobupivacaine in a double-blinded, randomized and crossover study. Neither anesthetic agent contained a vasoconstrictor. The time to onset of anesthesia, duration of surgery, intraoperative bleeding, hemodynamic parameters, the duration of postoperative analgesia and anesthesia as well as postoperative visual analogue scale (VAS) scores were evaluated.Results: The time to onset of anesthesia with articaine (80.28 ± 19.27 seconds) was significantly less compared to levobupivacaine (136.69 ± 33.52 seconds). The average duration of postoperative anesthesia for levobupivacaine and articaine was 8 hours and 3 hours, respectively (p = 0.000). The mean duration of postoperative analgesia for levobupivacaine and articaine was 7-8 hours and 3 hours, respectively (p = 0.000). Additionally, VAS scores with levobupivacaine were significantly lower than articaine up to the 4th postoperative hour. Significantly less bleeding was seen in the surgeries performed with levobupivacaine.Conclusion: 0.5% Levobupivacaine resulted in a longer period of postoperative anesthesia and analgesia, a longer time to onset of anesthesia, and less postoperative pain compared to 2% articaine.