bluuebunny/crossref_metadata_2025 huggingface dataset:
EFICIÊNCIA DE TRICHODERMA SPP. NA PROMOÇÃO DO CRESCIMENTO DE MUDAS DE AÇAIZEIRO (EUTERPE OLERACEA MART.)
Authors: Pio-Gonçalves Renata , Lima-Primo Hyanameyka Evangelista de , Schurt Daniel Augusto , Curcino Alexandre , Do Nascimento Cunha Eliane , Henrique Oliveira Gomide Plínio
Published: January 2023

A qualidade das mudas de açaizeiro influencia a sobrevivência e produtividade das plantas após o transplantio. A utilização de microrganismos benéficos no processo de produção de mudas auxilia na adaptação das plantas para o momento do transplante. Nesse estudo avaliou-se os efeitos da inoculação de isolados de Trichoderma spp. no crescimento de mudas de açaizeiro. Foi conduzido um experimento com replicação, considerando-se três isolados de fungos e os dois métodos de inoculação influenciando variáveis químicas e biométricas. Quinzenalmente, avaliou-se a altura da planta, o diâmetro do coleto e o número de folhas. Na avaliação final, foram mensurados o comprimento da raiz, massa seca da parte aérea e da raiz, massa seca total e teores de macro e micronutrientes foliares. As mudas inoculadas apresentaram incremento significativo na altura e no diâmetro do coleto, indicando a capacidade de uso desses microrganismos como promotores de crescimento, podendo influenciar na qualidade das mudas e aumentar as chances de sobrevivências das mesmas em campo.
Programa nacional de alimentação escolar: dificuldades na aquisição da agricultura familiar na perspectiva dos gestores de escolas estaduais em Alta Floresta - MT
Authors: Gervazio Wagner , França de Sousa Kauany , Roboredo Delmonte , Matheus da Costa de Figueiredo Adriana , Araujo de Oliveira Ana Luisa
Published: January 2023

O Programa Nacional de Alimentação Escolar - PNAE é a política que dispõe sobre o atendimento da alimentação escolar e consolida a vinculação da agricultura familiar. O objetivo desse trabalho foi avaliar a acessibilidade do PNAE através da percepção dos gestores de escolas estaduais em Alta Floresta – MT. Os dados foram obtidos de entrevistas estruturadas com o auxílio de um questionário. A pesquisa foi realizada com gestores de 16 escolas estaduais. Os dados foram analisados de forma qualitativa, através da análise do conteúdo e uso de estatística multivariada. Os gestores acreditam que o PNAE contribui tanto para a renda familiar quanto para a permanência dos agricultores no campo. No entanto, a burocracia do processo; a falta de produtos; a logística; a pouca participação dos agricultores; e intermediários, obstaculizam a operacionalização do PNAE. Políticas públicas como o PNAE são importantes para o fortalecimento da agricultura familiar, para a produção de alimentos e incentivo à produção agroecológica.
A Content Analysis of Articles in the Turkish Early Childhood Education Context
Authors: Güvelioğlu Elif , Tantekin Erden Feyza
Published: January 2023

The aim of this study was to examine articles from the field of early childhood education published in Turkish academic journals. Descriptive and methodological characteristics of the articles were scrutinized along with investigation and categorization of their research topics. 822 articles from 62 journals, published between 2008 and 2018 were examined via content analysis. Findings showed that almost half the articles were designed as quantitative studies (n = 407). In complement, the three most common research methods were identified as surveys, (n = 123), experimental studies (n = 102), and correlational studies (n = 96). Accordingly, the most widespread choice of sample group was children (35.6%). Additionally, 43.5% of the articles did not clarify their sampling methods. Furthermore, the most studied research topics included educational subjects (n = 424). Amongst the sub-categories of educational research, special education, and inclusion were the most prevalent at a rate of 10.1%.
Okul Öncesi Eğitimi Öğretmenlerinin Erken Çocukluk Dönemi Yaşam Becerilerine İlişkin Görüşlerinin İncelenmesi
Authors: Yıldırım Yakup , Çetin Feyzanur
Published: January 2023

Bu araştırmanın amacı, okul öncesi eğitimi öğretmenlerinin erken çocukluk dönemi yaşam becerilerine ilişkin bilgi ve farkındalık düzeylerinin metaforlar aracılığıyla fenomenolojik olarak incelenmesidir. Araştırma, okul öncesi öğretmenlerinin erken çocukluk dönemi yaşam becerilerine yönelik bilgi ve farkındalık düzeyinin belirlenerek ileriki çalışmalara ışık tutacak olması açısından önem taşımaktadır. Araştırmanın çalışma grubunu, Antalya, Burdur ve Isparta illerindeki milli eğitim bakanlığına bağlı resmi ve özel okul öncesi eğitim kurumunda çalışmakta olan en az bir yıl öğretmenlik tecrübesine sahip 36 okul öncesi öğretmeni oluşturmaktadır. Araştırmada nitel araştırma desenlerinden fenomenoloji (olgubilim) deseni kullanılmıştır. Elde edilen metaforik veriler, araştırmacılar tarafından içerik analizi tekniğiyle analiz edilmiştir. İçerik analizi ile birbiriyle örtüşen veriler belirli kavramlar ve kategoriler çerçevesinde bir araya getirilerek üç kategori başlığı oluşturulmuştur. Bu kategoriler sırasıyla; “1.   Birey olmanın ve yaşamın anahtarı olarak yaşam becerileri” (1), “Gelişimin odak noktası olarak yaşam becerileri” (2), “Sosyal değer olarak yaşam becerileri” (3) dir. Araştırmadan elde edilen sonuçlara göre; okul öncesi öğretmenleri, yaşam becerilerinin; çocukların olumlu sosyal gelişimlerinde, sosyal ilişkilerinde kontrollü duygu ve tavırlar geliştirebilmelerinde, problem çözücü olabilmelerinde, sosyal olgunluklarında, kendini ifade edebilmelerinde ve sonucunda özgüvenli birey olmaları üzerinde etkili olduğunu belirtmişlerdir.
Okul Öncesi Dönem Çocuklarının Temel Okul Becerilerinin İncelenmesi
Authors: Yıldız Fatma Ülkü , Kayılı Gökhan
Published: January 2023

Bu araştırmanın amacı; okul öncesi eğitimi alan 48-72 aylık çocukların matematik becerileri ile konuşulan dil, okuma-yazma becerilerinin arasındaki ilişkiyi irdelemek, ayrıca yaş ve cinsiyete göre matematik ve konuşulan dil, okuma-yazma gelişimleri arasındaki ilişkiyi araştırmaktır. Araştırma ilişkisel tarama modelinde desenlenmiştir. Örneklem grubu Konya’da resmi bağımsız anaokullarından eğitim alan 234 çocuktan oluşmaktadır. Verilerin toplanmasında “TOBE-3” alt testlerinden “Matematik”, “Konuşulan Dil” ve “Okuma-Yazma” kullanılmıştır. Verilerin analizinde parametrik testlerden bağımsız gruplarda t-testi, ANOVA, Pearson Korelasyon Katsayısı ve Çoklu Doğrusal Regresyon analizi işlemleri uygulanmıştır. Araştırma sonucunda; 48-72 aylık çocukların matematik becerileri puanları ile konuşulan dil becerileri, okuma ve yazma becerileri puanları arasında pozitif yönde bir ilişki olduğu; okuma ve yazma becerileri puanlarının çocukların matematik becerileri puanlarını yordadığı ancak konuşulan dil puanlarının matematik becerisi puanlarını yordamadığı sonucuna ulaşılmıştır.  Cinsiyetin çocukların matematik becerileri ve konuşulan dil becerilerinde anlamlı düzeyde farklılaşmadığı ancak okuma ve yazma becerilerinde kız çocuklarının daha yüksek puanlar aldıkları görülmüştür. Büyük yaş grubu lehine istatistiksel olarak farklılaşma olduğu bulgularına ulaşılmıştır.
Memorias: XIV foro internacional del emprendedor
Authors:   Universidad del Azuay, Crespo-Merchán Miguel , Erazo-Garzón Lenin ,   Universidad del Azuay, Maldonado-Matute Juan Manuel ,   Universidad del Azuay, González-Calle María José ,   Universidad del Azuay, Vera-Reino José ,   Universidad del Azuay, Freire-Pesántez Andrea ,   Universidad del Azuay, Abad-Merchán Matías ,   Universidad del Azuay, Astudillo-Rodríguez Catalina Verónica ,   Universidad del Azuay, Andrade-Dueñas Iván ,   Universidad del Azuay, Huerta-Rincón Gustavo Vicente ,   Universidad del Azuay, Martínez-García María Dolores ,   Universidad del Azuay, Sempértegui-Muñoz Juan Pablo ,   Universidad del Azuay, Burneo-Celi Vanessa ,   universidad del Azuay
Published: January 2023

“Puedes hacer cualquier cosa, pero no puedes hacerlo todo”. Una premisa que todo emprendedor debe conocer, pero sobre todo reconocer que debe hacer lo que mejor sepa hacer. Para un emprendedor, una microempresa, un productor o un startup, el proceso de comercialización y la entrega de productos suele terminar en un serio dolor de cabeza y convertirse en frustración. Esta es la problemática de muchos de los artesanos de este país, quienes fueron analizados en las ferias artesanales mediante la técnica de investigación comercial. A esta situación micro empresarial se suma la proposición “has lo que sabes hacer y deja que otros hagan el resto”, aspecto que al analizarlo despertó la idea de desarrollar Almerkadito.com, un portal de comercialización de productos generados por emprendedores, sin la necesidad de incluir intermediarios en su cadena de distribución. AlMerkadito.com, que en un corto plazo se convertirá en empresa, es el resultado de un producto más desarrollado por Fokus Corp S.C., una consultora ecuatoriana con 30 años de trayectoria en el mercado, cuyo enfoque son las empresas del sector MPYME. La propuesta de este nuevo modelo es permitir que el emprendedor se dedique a su negocio y deje que, mediante una plataforma, el cliente revise los productos que se presentan en las ferias, agregarlos a un carrito de compras virtual, pagar con tarjeta, seleccionar el medio de entrega y recibirlo directamente en la puerta de su casa u oficina. Para determinar su viabilidad de implementación y su grado de aceptación, este producto informático fue puesto como piloto dentro de la ciudad de Cuenca; los resultados obtenidos permitieron tomar decisiones sobre: captación de proveedores, logística de distribución, mecanismos de pago y rotación de campañas publicitarias; considerándose como punto de partida para el comercio electrónico. 243 páginas ISBN: 978-9942-778-59-8 e-ISBN:978-9942-778-60-4
Nudo: Manual básico de ilustración
Authors:   Universidad del Azuay, Sevilla Pedro , Tripaldi-Proaño Toa ,   Universidad del Azuay, Landívar-Feicán Roberto ,   Universidad del Azuay, Malo-Torres Juan Santiago ,   Universidad del Azuay
Published: January 2023

Este manual básico es una compilación de las diversas técnicas y estilos más utilizados en el campo de la ilustración actual. Su propósito es fortalecer los conocimientos de los ilustradores e incentivar el uso de nuevas técnicas. La ilustración es un mundo en el que la imaginación y la creatividad no tienen límites. Este manual te provee de conocimientos. 112 páginas ISBN: 978-9978-325-97-1 e-ISBN: 978-9978-325-67-4
Mítico: Evocar el pasado revelar el origen
Authors:   Universidad del Azuay, Alvarracín-Espinoza Cristian , Tripaldi-Proaño Anna ,   Universidad del Azuay, Estrella-Toral Rafael ,   Universidad del Azuay, Serrano-Cordero Catalina ,   Universidad del Azuay
Published: January 2023

Esta obra fue realizada como un tributo a esta tierra llamada Ecuador y a los seres mitológicos que aún la habitan, así como a los pueblos en donde estos relatos permanecen. Siendo el centro de esta obra la mitología, me permito tocar los bordes de la leyenda y el cuento porque tienen algo en común: la imaginación. Evocar el pasado y sobrevolar la historia, son tareas que nos pueden llevar a comprender los rastros que nos han formado desde el origen de los tiempos y que permanecen latentes, negándose a ser olvidados, pasando de generación en generación en forma de narrativa oral que da vida a personajes, animales, criaturas fantásticas, lugares imposibles, tiempos extraños, a la vida y a la muerte. 48 páginas ISBN: 978-9978-325-89-6 e-ISBN:978-9978-325-71-1
Radiología básica: Manifestaciones radiológicas y su adecuada interpretación
Authors:   Universidad del Azuay, Espinoza-Cárdenas David , Figueroa-Pasos Esteban ,   Universidad del Azuay, Ledesma-Ayora Marco ,   Universidad Católica de Cuenca
Published: January 2023

Los rayos X fueron descubiertos en 1895 por Wilhelm Conrad Roentgen, luego de estudios de radiación en tubos de rayos catódicos. Los médicos los utilizan para identificar los diagnósticos, como proyección del estado del interior de alguna parte del cuerpo, infecciones, tumores, fracturas y otros. Produce sinergia en la interpretación e investigación en escenarios de inter-multi y transdisciplinariedad. Se podría considerar la radiología como unidad básica de la medicina con la tecnología. La primera revista sobre rayos X apareció en 1896 y sus trabajos de radioactividad, desde el ámbito epistemológico. La fenomenología ha impulsado avances en la radiología en base a múltiples experimentos. “(...) de forma práctica el método científico y el pragmatismo, (...) [posibilitan] el enlace con la observación, formulación de hipótesis, comprobación de hipótesis y establecer como principio” 102 páginas ISBN: 978-9942-778-50-5 e-ISBN: 978-9942-778-53-6
Memorias del Congreso de Estudios de la Ciudad CIVITIC 2017: 01 Derecho a la ciudad
Authors:   Universidad del Azuay, Hermida-Palacios Carla
Published: January 2023

La palabra CIVITIC nació de la idea de integrar "civitas", que da cuenta de la ciudadanía como fuente de derechos y deberes en torno a la ciudad, y "tics", que concibe a las tecnologías de información y comunicación como herramientas necesarias para producir conocimiento en red. Es así que a través de plataformas virtuales se habían mantenido 6 foros virtuales antes del Congreso de Estudios de la Ciudad CIVITIC 2017 y múltiples reuniones de coordinación. En los foros virtuales previos al Congreso se conversó sobre el estado de la investigación urbana en las ciudades ecuatorianas, las ciudades en los procesos electorales, la gestión de riesgos, las políticas públicas, la economía urbana y los ejes clave de reflexión de nuestras ciudades. 164 Páginas ISBN: 978-9942-778-38-3 e-ISBN: 978-9942-778-39-0
Pelatihan Penyusunan Teknik Penilaian Hasil Belajar Bagi Guru-Guru di SMPN Satu Atap Batu Rintang
Authors: Hadi M. Samsul , Anam M. Chairul , Najamuddin M.
Published: January 2023

Kegiatan pengabdian ini dilaksanakan di SMPN 1 Atap Batu Rintang Kecamatan Praya Timur. Kegiatan ini bertujuan untuk melatih guru dalam menyusun teknik penilaian hasil belajar. Kegiatan ini sangat bermanfaat memberikan pengetahuan dan pemahaman yang lebih mendalam tentang pentingnya menyusun instrumen hasil belajar. Metode yang digunakan adalah partisipatif dan kolaboratif. Kegiatan ini sekaligus menjadi dorongan bagi guru-guru untuk menyampaikan informasi khususnya kepada guru-guru lain tentang pentingnya peran guru dalam pengembangan penilaian hasil belajar siswa. Hasil kegiatan ini dapat meningkatkan pengetahuan guru dalam menyusun penilaian hasil belajar Dengan demikian kegiatan pelatihan ini secara tidak langsung menjadi bagian penting untuk turut menumbuhkan kesadaran bagi masyarakat untuk memperbaiki proses pembelajaran.
Bibliometric Study of Publications of Arab Dental Universities in Indexed Journals between 2010 And 2020
Authors: Anas Bennani , Hafssa Bouzroud , Meriem El Mdaghri
Published: January 2023

Background: Bibliometric is the quantitative analysis of the characteristics of documents published by researchers. Aim: The aim of this study is to make a bibliometric analysis of publications of Arab countries’ universities in dentistry between January 2010 and December 2020 based on publications appeared in the indexed journals on PubMed. Materials and methods: Our work is an exhaustive retrospective descriptive study. Results: Out of 22 Arab countries, 17 have at least one university of dentistry. Our study showed the following results: - 1337 articles were published. - 59 universities from 15 countries published, which represents 32.2%. - 433 professors have published at least one article, which represents 15.58%. - Saudi Arabia is in the lead with 524 articles, which represents 39.19%. - The Saudi Pr. Sadeq Ali Al Maweri occupies the 1st place with 27 articles. - The Moroccan Bourzgui Farid and Ousehal Lahcen from Hassan II University occupy the 11th place with 8 articles. - The contribution of Moroccan authors is 4.11%, occupying the 8th position among Arab countries. - Descriptive cross-sectional studies are at the top of the ranking with 30.96% of articles. - Oral surgery is at the top of the ranking with 30.66% of articles. Conclusion: The results obtained showed that the rate of scientific production in dentistry at Arab dental universities has increased over the years; however, it is still far from that of European and American universities. The infrastructure of research in the Arab world requires efforts from all those responsible.
Comparative Assessment of The Fracture Resistance of Teeth Instrumented by Two Different Nickel Titanium Rotary Systems
Authors: Elgendy Ali Youssef
Published: January 2023

Aim: This study aimed to compare the fracture resistance exhibited by roots on instrumentation using two endodontic rotary systems: SANI S3 and EdgeEndo X7 rotary file systems. Materials and Methods: Sixty recently extracted human mandibular premolars comprising single root canals were selected in this study. All specimens were decoronated and mounted perpendicularly in self-cure acrylic resin blocks exposing 6 mm of the roots out of the acrylic resin blocks. The specimens were divided into two experimental groups, according to NiTi rotary systems used and one control group (n = 20). After instrumentation, the specimens of both experimental groups were then filled using master Gutta-percha cones size 35 (0.04 taper) and obturation was done using continuous wave compaction technique. The specimens were kept at 37 °C and 100% humidity for 2 weeks to allow complete setting of the sealer. Root fracture resistance was assessed using a universal testing machine (Instron) and the amount of load necessary for root fracture was recorded in Newtons (N). Statistics: Data were collected, tabulated and statistically analyzed using one-way ANOVA test and Tukey’s posthoc test. Results: Group C (control) exhibited the highest mean fracture force (357.13 ± 20.61) while group A (SANI S3) showed the lowest mean fracture force (192.60 ± 22.73). One-way ANOVA test showed statistically significant differences between tested groups. Regarding inter-group comparisons using Tukey’s test, there was a significant statistical difference between groups (A and B) and between groups (A and C). Furthermore, there was a statistically significant difference between groups (B and C). (P?0.05) Conclusion: 1-Root canal instrumentation with NiTi rotary files possessed a negative impact on roots and higher risks of root fractures compared to intact unprepared roots. 2-Design of NiTi files with improved cutting efficiency could diminish the risk of crack formation in root canal dentinal walls.
Stem Cell Treatment of Autism Spectrum Disorders
Authors: Gaston Grace , Gallicchio Vincent S
Published: January 2023

Autism is a spectrum of neurodevelopmental disorders. It appears differently in all individuals with ASDs and has recently become popular in research. There are many suspected genetic causes of autism, but no cure has been proven to work to treat the disorder. Stem cells have been studied for their potential role in treating ASDs. The most promising results have come from studies utilizing MSCs or hESCs. Experiments have shown that using these stem cells can reduce the severity of autism and increase the quality of life. Stem cells have also been used to model different forms of autism, including Rett Syndrome and Fragile X Syndrome. The most common stem cells used for modeling autism are iPSCs, which can retain the original genetics of the patient it was derived from. By studying autism precisely how it appears in the body, novel drug therapies and treatments can be designed. There are moral considerations that need to be taken into account when studying novel therapies for autism. The most common participants in these studies are children. This population needs to be protected, and researchers should keep their best interests in mind. Also, scientists should acknowledge their work's impact on the general population and hold each other accountable for the work they release.
NETRALITAS APARATUR SIPIL NEGARA DALAM PEMILIHAN KEPALA DAERAH DI PROVINSI JAMBI TAHUN 2020
Authors: Putra Firmansyah , Pratiwi Cholillah Suci
Published: January 2023

Penelitian ini bertujuan untuk mengetahui penyebab Aparatur Sipil Negara (ASN) cenderung bersikap tidak netral dalam Pemilihan Kepala Daerah (Pilkada) dan untuk mengetahui upaya mewujudkan netralitas Aparatur Sipil Negara dalam Pemilihan Kepala Daerah (Pilkada). Jenis penelitian ini adalah penelitian hukum non doktrinal/penelitian hukum empiris atau penelitian hukum sosiologis, yaitu penelitian hukum yang memperoleh data dari sumber data primer dan sekunder. Objek penelitian ini adalah Badan Pengawas Pemilihan Umum (Bawaslu) Provinsi Jambi dan Komisi Pemilihan Umum (KPU) Provinsi Jambi. Dalam penelitian ini penulis memperoleh data melalui penelitian analisis dan lapangan (field research), kemudian dianalisis secara kualitatif untuk menghasilkan data yang bersifat deskriptif. (ASN) pada Pilkada di Provinsi Jambi belum terlaksana dengan baik karena masih ditemukan ASN yang tidak netral. Kedua, ketidaknetralan ASN masuk ketegori ringan. Proses mekanisme penjatuhan sanksi kepada ASN yang tidak netral pada pelaksanaan Pilkada di Provinsi Jambi juga masih berjalan. Bawaslu dan KPU dalam hal ini sudah berupaya melakukan beberapa tindakan preventif guna menghilangkan ketidaknetaralan ASN dalam Pilkada, antara lain melakukan sosialisasi dengan berbagai kegiatan yang berisikan tentang etika dan netralitas ASN yang wajib dijunjung tinggi serta asas-asas netralitas yaitu tidak berpihak, netral, bebas konflik kepentingan, bebas intervensi politik, adil, dan melayani. Pewujudan netralitas ASN dalam Pilkada dapat dilakukan dengan melibatkan secara optimal peranan beberapa institusi terkait, antara lain Komisi Aparatur Sipil Negara (KASN), Pimpinan Birokrasi, Inspektorat Daerah, dan Badan Kepegawaian Daerah, Komisi Pemilihan Umum, dan Badan Pengawas Pemilu.
PEMBERDAYAAN EKONOMI MASYARAKAT BERBASIS APLIKASI ELEKTRONIK BUMDESA SUGIHWARAS (e-BES) DI DESA SUGIHWARAS KECAMATAN CANDI KABUPATEN SIDOARJO
Authors: Yasmin Afandi  , Ananta Prathama
Published: January 2023

Pemberdayaan ekonomi masyarakat sangat perlu dilakukan khususnya di pedesaan. Pemberdayaan ekonomi untuk penguatan masyarakat melalui usaha-usaha yang dimiliki masyarakat untuk mendapatkan pendapatan yang memadai, mendapatkan informasi, mendapatkan pengetahuan dan ketrampilan, sehingga diharapkan dapat berdampak kepada peningkatan hasil secara ekonomi. Penelitian ini memiliki tujuan untuk mendeskripsikan Pemberdayaan Ekonomi Masyarakat Berbasis Aplikasi Elektronik BUMDesa Sugihwaras (e-BES) Di Desa Sugihwaras Kecamatan Candi Kabupaten Sidoarjo. Jenis penelitian yang digunakan dalam penelitian ini adalah bersifat deskriptif dengan pendekatan kualitatif. Fokus penelitian ini menggunakan pendekatan pemberdayaan (5P) yang dikemukakan oleh Suharto yang dikutip oleh Hamid (2018) yakni pemungkinan, penguatan, perlindungan, penyokongan, dan pemeliharaan. Kemudian sumber data dalam penelitian ini yakni sumber data primer dan sumber data sekunder. Data primer yang didapatkan dari informan yang telah ditunjuk, dokumentasi serta observasi yang dilakukan. Sedangkan data sekunder dalam penelitian ini yakni untuk melengkapi kebutuhan data penelitian. Hasil penelitian ini menunjukkan bahwa Pemberdayaan Ekonomi Masyarakat Berbasis Aplikasi Elektronik BUMDesaSugihwaras (e-BES) Di Desa Sugihwaras Kecamatan Candi Kabupaten Sidoarjo belum dilaksanakan secara keseluruhan. Hal ini dapat dilihat bahwa pemungkinan yang hanya dilakukan dengan baik sedangkan penguatan dan pemeliharaan sudah dilaksanakan namun belum optimal serta perlindungan, penyokongan belum dilaksanakan oleh BUMDesa Sukses Bersama Desa Sugihwaras Kecamatan Candi Kabupaten Sidoarjo
Methylisothiazolinone and Methylchloroisothiazolinone: New Insights
Authors: Rodrigues-Barata Ana Rita , Conde-Salazar Luis
Published: January 2023

Methylisothiazolinone (MI), along with Kathon™ CG (methylchloroisothiazolinone/MI), are widely used preservatives to prevent bacterial overgrowth in aqueous solutions of various types of cosmetic, household, and industrial products. Because of its high sensitising power and widespread use, MI is currently one of the most common causes of allergic contact dermatitis, both in our private lives and in the occupational field. As it was thought that MI had less sensitivity capacity, it started to be commercialised separately, and a new epidemic of sensitisation to these preservatives has been observed in recent years. MI should be included separately in the standard patch testing series. Also, the use of isothiazolinones should be revised, and legislative measures from the competent authorities should be implemented in order to resolve this problem.
NEW DECOMPOSITIONS OF SOFT CONTINUITY IN SOFT TOPOLOGICAL SPACES
Authors: GÜZEL ERGÜL Zehra
Published: January 2023

The aim of this paper is to produce new decompositions of soft continuity.
For this reason, we first have introduced two new sets concepts named as
soft AC-set with soft BC-set in soft topological spaces. Compairing with
this two soft sets concepts and others soft set kinds, we have obtained two
decompositions of soft open sets, supported by counterexamples. Utilizing
soft AC-set and soft BC-set concepts, we have introduced two functions
concepts named as soft AC-continuous with soft BC-continuous functions and
we have obtained a new decomposition of soft continuity.
The value of impermanent carbon credits
Authors: Balmford Andrew , Keshav Srinivasan , Venmans Frank , Coomes David , Groom Ben , Madhavapeddy Anil , Swinfield Thomas
Published: January 2023

A new framework linking economics with remote-sensing means impermanent carbon reduction can be directly compared with permanent drawdown.
BIMBINGAN TEKNIS PEMBUATAN KOMPOS DI DESA BINAAN POLINEMA, WRINGIN SONGO, TUMPANG
Authors: Zamrudy Windi , Chrisnandari Rosita Dwi , Naryono Eko
Published: January 2023

Wringinsongo is one of the rural areas in Tumpang District, Malang Regency, East Java Province that offers numerous advantages, particularly in the agricultural and tourism sectors. Wringinsongo's growing population, increasingly diverse consumption patterns, the establishment of modern markets, and community economic activities all contribute to increased waste generation. The volume of waste at the Wringinsongo Temporary Disposal Site (TPS) has reached 15 m3, causing environmental and social issues. The majority of the waste in TPS and TPA is organic waste generated by households. The accumulation of organic waste in TPS and TPA will produce anaerobic decomposition compounds, namely methane gas, which is the primary cause of the greenhouse effect, which has a negative impact on the environment. Composting is one method of waste processing that can be used to reduce waste in TPA and TPS. Basic composting knowledge and skills are acquired during the composting process in order to achieve the desired results. Thus, community service is provided with the intention of offering technical composting guidance. Counseling and direct practice in composting are the methods used. Counseling is used to provide insight into waste processing via composting, while practice is employed to provide skills and direction in the composting process. This activity generates initial compost, which can be added to with new organic waste every day, enables household organic waste to be managed independently.
INSTALASI JARINGAN KOMPUTER SEBAGAI PENUNJANG LAYANAN ADMINISTRASI MASYARAKAT DESA KARANGDUREN KAB. MALANG
Authors: Yuri Ariyanto  , Nurul Asri Atiqah , Yunhasnawa Yoppy , Ushbah Mubarok Faiz , Mungki Astiningrum
Published: January 2023

At the village level, administrative services are the main service and are directly related to the needs of the community. Administrative services can be in the form of issuing certificates, cover letters, letters of recommendation, legalization, and other letters. For administrative services in correspondence, the problems faced by the Karangduren village office regarding the installation of computer networks. Currently, computers that store data and applications for mailing repositories are not yet connected to other computers, resulting in queuing and slow document processing. With these problems, PPM (Pengabdian Pada Masyarakat) activities will be carried out in the form of "Implementation of Computer Network Installation to Support Mailing Repository Applications at the Karangduren Village Office, Kec. Pakisaji, Kab. Malang". Through PPM activities in Karangduren village, Kec. Pakisaji, Kab. Malang is done to help solve problems regarding the installation of computer networks. By installing a computer network at the village office, all computers in the village office can be connected. So with the installation of this computer network, it can improve the service and performance of the Karangduren Village Office in serving the community. The results of this PPM activity will produce a computer network installation design and a basic computer network manual.
ОСОБЕННОСТИ КОМПОНЕНТНОГО СОСТАВА ТЕЛА ЮНОШЕЙ ГУДЖАРАТСКОЙ НАРОДНОСТИ
Authors: Калмин Олег , Фрунзе Елена , Лукьяненко Данила
Published: January 2023

Purpose of the study was: to investigate the body composition of the young
Gujarati men. The object of the study was 147 young men of the Gujarat ethnic
group at the age of 17–21. The study was carried out using anthropometric
techniques. Bone, muscle and fat components of body mass, body mass index
and body surface area were calculated. The average body length of Gujarat youths
was determined as 171,75 ± 0,50 cm, body weight – 63,57 ± 1,17 kg. The average
thickness of the fat fold on the back was 1,80 ± 0,08 cm, on the front shoulder
– 0,64 ± 0,04 cm, on the back shoulder – 0,81 ± 0,04 cm, on the forearm – 0,53
± 0,03 cm, on the chest – 1,07 ± 0,05 cm, on the abdomen – 2,22 ± 0,10 cm, on
the thigh 1,69 ± 0.07 and on the leg – 1,11 ± 0,05. The skin fold on the back of
the hand was 0,21 ± 0,01 cm. The average value of the body mass index among
Gujarati boys was 21,50 ± 0,36 kg / m2. The absolute mass of the fat component
in young men was 14,50 ± 0,68 kg, the mass of the muscle component was 23,50
± 0,36 kg, and the absolute mass of the bone component was 10,09 ± 0,12 kg. The
relative mass of the fat component of young men was 21,48 ± 0,65%, the relative
mass of the muscle component was 37,75 ± 0,51% and the bone component
was 16,31 ± 0,21%. The predominant component in the groups with normal,
overweight and underweight was muscle, in the obese group, it was - fat.
Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality
Authors: Parrón-Ballesteros Jorge , Gordo Rubén García , López-Rodríguez Juan Carlos , Olmo Nieves , Villalba Mayte , Batanero Eva , Turnay Javier
Published: January 2023

The “epithelial barrier hypothesis” states that a barrier dysfunction can result in allergy development due to tolerance breakdown. This barrier alteration may come from the direct contact of epithelial and immune cells with the allergens, and indirectly, through deleterious effects caused by environmental changes triggered by industrialization, pollution, and changes in the lifestyle. Apart from their protective role, epithelial cells can respond to external factors secreting IL-25 IL-33, and TSLP, provoking the activation of ILC2 cells and a Th2-biased response. Several environmental agents that influence epithelial barrier function, such as allergenic proteases, food additives or certain xenobiotics are reviewed in this paper. In addition, dietary factors that influence the allergenic response in a positive or negative way will be also described here. Finally, we discuss how the gut microbiota, its composition, and microbe-derived metabolites, such as short-chain fatty acids, alter not only the gut but also the integrity of distant epithelial barriers, focusing this review on the gut-lung axis.
Comprehensive screening strategy coupled with structure-guided engineering of l-threonine aldolase from Pseudomonas putida for enhanced catalytic efficiency towards l-threo-4-methylsulfonylphenylserine
Authors: Li Lihong , Zhang Rongzhen , Xu Yan , Zhang Wenchi
Published: January 2023

l-Threonine aldolases (TAs) can catalyze aldol condensation reactions to form β-hydroxy-α-amino acids, but afford unsatisfactory conversion and poor stereoselectivity at the Cβ position. In this study, a directed evolution coupling high-throughput screening method was developed to screen more efficient l-TA mutants based on their aldol condensation activity. A mutant library with over 4000 l-TA mutants from Pseudomonas putida were obtained by random mutagenesis. About 10% of mutants retained activity toward 4-methylsulfonylbenzaldehyde, with five site mutations (A9L, Y13K, H133N, E147D, and Y312E) showing higher activity. Iterative combinatorial mutant A9V/Y13K/Y312R catalyzed l-threo-4-methylsulfonylphenylserine with a 72% conversion and 86% diastereoselectivity, representing 2.3-fold and 5.1-fold improvements relative to the wild-type. Molecular dynamics simulations illustrated that additional hydrogen bonds, water bridge force, hydrophobic interactions, and π-cation interactions were present in the A9V/Y13K/Y312R mutant compared with the wild-type to reshape the substrate-binding pocket, resulting in a higher conversion and Cβ stereoselectivity. This study provides a useful strategy for engineering TAs to resolve the low Cβ stereoselectivity problem and contributes to the industrial application of TAs.
High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
Authors: Chen Lihua , Liu Bo , Ren Lixia , Du Hao , Fei Chunhua , Qian Chang , Li Bin , Zhang Ruixia , Liu Haixia , Li Zongjie , Ma Zhiyong
Published: January 2023

Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities (such as depression and anxiety). Here, we conducted a randomized clinical study to analyze the changes in gut microbiota, serum metabolism and emotional mood of patients with T2DM after consumption of a high-fiber diet. The glucose homeostasis of participants with T2DM was improved by the high-fiber diet, and the serum metabolome, systemic inflammation and psychiatric comorbidities were also altered. The increased abundances of Lactobacillus, Bifidobacterium and Akkermansias revealed that the proportions of beneficial gut microbes were enriched by the high-fiber diet, while the abundances of Desulfovibrio, Klebsiella and other opportunistic pathogens were decreased. Therefore, the current study demonstrated that the intestinal microbiota alterations which were influenced by the high-fiber diet could improve the serum metabolism and emotional mood of patients with T2DM.
Carbapenem-resistant gram-negative bacterial infection in intensive care unit patients: Antibiotic resistance analysis and predictive model development
Authors: Liao Qiuxia , Feng Zhi , Lin Hairong , Zhou Ye , Lin Jiandong , Zhuo Huichang , Chen Xiaoli
Published: January 2023

In this study, we analyzed the antibiotic resistance of carbapenem-resistant gram-negative bacteria (CR-GNB) in intensive care unit (ICU) patients and developed a predictive model. We retrospectively collected the data of patients with GNB infection admitted to the ICU of the First Affiliated Hospital of Fujian Medical University, who were then divided into a CR and a carbapenem-susceptible (CS) group for CR-GNB infection analysis. Patients admitted between December 1, 2017, and July 31, 2019, were assigned to the experimental cohort (n = 205), and their data were subjected to multivariate logistic regression analysis to identify independent risk factors for constructing the nomogram-based predictive model. Patients admitted between August 1, 2019, and September 1, 2020, were assigned to the validation cohort for validating the predictive model (n = 104). The Hosmer−Lemeshow test and receiver operating characteristic (ROC) curve analysis were used to validate the model’s performance. Overall, 309 patients with GNB infection were recruited. Of them, 97 and 212 were infected with CS-GNB and CR-GNB, respectively. Carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) were the most prevalent CR-GNB. The multivariate logistic regression analysis results of the experimental cohort revealed that a history of combination antibiotic treatments (OR: 3.197, 95% CI: 1.561–6.549), hospital-acquired infection (OR: 3.563, 95% CI: 1.062–11.959) and mechanical ventilation ≥ 7 days (OR: 5.096, 95% CI: 1.865–13.923) were independent risk factors for CR-GNB infection, which were then used for nomogram construction. The model demonstrated a good fit of observed data (p = 0.999), with an area under the ROC curve (AUC) of 0.753 (95% CI: 0.685–0.820) and 0.718 (95% CI: 0.619–0.816) for the experimental and validation cohort, respectively. The decision curve analysis results suggested that the model has a high practical value for clinical practice. The Hosmer−Lemeshow test indicated a good fit of the model in the validation cohort (p-value, 0.278). Overall, our proposed predictive model exhibited a good predictive value in identifying patients at high risk of developing CR-GNB infection in the ICU and could be used to guide preventive and treatment measures.
A bibliometric analysis of sepsis-induced myocardial dysfunction from 2002 to 2022
Authors: Yao Hanyi , Liu Shufang , Zhang Zhiyu , Xiao Zixi , Li Dongping , Yi Zhangqing , Huang Yuyang , Zhou Haojie , Yang Yifeng , Zhang Weizhi
Published: January 2023

Background

Sepsis-induced myocardial dysfunction (SIMD) has a significant contribution to sepsis-caused death in critically ill patients. In recent years, the number of published articles related to SIMD has increased rapidly. However, there was no literature that systematically analyzed and evaluated these documents. Thus, we aimed to lay a foundation for researchers to quickly understand the research hotspots, evolution processes and development trends in the SIMD field via a bibliometric analysis.

Methods

Articles related to SIMD were retrieved and extracted from the Web of Science Core Collection on July 19th, 2022. CiteSpace (version 6.1.R2) and VOSviewer (version 1.6.18) were used for performing visual analysis.

Results

A total of 1,076 articles were included. The number of SIMD-related articles published each year has increased significantly. These publications mainly came from 56 countries, led by China and the USA, and 461 institutions, but without stable and close cooperation. As authors, Li Chuanfu published the most articles, while Rudiger Alain had the most co-citations. Shock was the journal with the most studies, and Critical Care Medicine was the most commonly cited journal. All keywords were grouped into six clusters, some of which represented the current and developing research directions of SIMD as the molecular mechanisms.

Conclusion

Research on SIMD is flourishing. It is necessary to strengthen cooperation and exchanges between countries and institutions. The molecular mechanisms of SIMD, especially oxidative stress and regulated cell death, will be critical subjects in the future.
Prediction model investigations of the reinforced fine-grained tailings dam overtopping failure
Authors: Chen Meibao , Jing Xiaofei , Xie Dongxu , Li Xiaoshuang , Zhang Yuanzhen , Liu Xiaohua
Published: January 2023

Overtopping dam break is a frequent accident in tailings reservoirs. However, little attention has been paid to the study of overtopping hydraulic erosion damage characteristics of tailings dam after adding reinforcement. Nowadays, there were few people have researched the prediction of the overtopping failure process of the reinforced tailings dam. It is important significance to establish a prediction model for the overtopping of reinforced tailings dam which aims at the problem of overtopping erosion of reinforced tailings. For the anti-erosion and anti-collapse effects of the reinforced tailings dam, a mathematical model for the development of the overtopping breach of the reinforced tailings dam is established. The formula of reinforced erosion rate derived from water flow shear stress theory, simulation of breach erosion development by time iteration method in the mathematical model. Secondly, the limit equilibrium method is used to analyze the stability of the reinforced breach slope. Then, the physical test is used to reproduce the dam failure process of the tailings dam. In addition, the development process of the breach and discharge are monitored. Ultimately, the maximum depth and width of the breach are in brilliant agreement with the calculated values.
Generation of the Early Cretaceous granitoid in the Dazeshan region, Jiaodong Peninsula: Implications for the crustal reworking in the North China Craton
Authors: Dong Leilei , Yang Zhiming , Bai Xin , Deng Chen
Published: January 2023

Lower crust-derived granitic rocks provide constraints on the crustal reworking process and consequently give hints on the destruction mechanism of the cratons. The North China Craton (NCC) underwent extensive crustal melting in the Mesozoic. This study investigated granitic intrusions in the Dazeshan region of the Jiaodong Peninsula. Whole-rock major and trace element analyses and zircon U-Pb ages coupled with Hf isotopes were used to reveal the crustal reworking processes. Zircons separated from the quartz porphyry, Linglong granite, rhyolite porphyry, and biotite granite showed weighted mean 206Pb-238U ages of 119.2 ± 1.0 Ma, 140.2 ± 1.0 Ma, 120.6 ± 0.5 Ma, and 119.9 ± 0.7 Ma, respectively. The quartz porphyry, rhyolite porphyry, and biotite granite had high silica contents (SiO2 = 74–77 wt.%) but low MgO, Co, and Ni concentrations. The calculated εHf(t) values for the rhyolite porphyry and the biotite granite ranged from −18.3 to −20.0 and −17.8 to −20.2, respectively. These geochemical features imply ancient crust sources. The quartz porphyry showed distinct primitive mantle-normalized rare earth element (REE) patterns and was characterized by lower ΣREE content and lack of pronounced negative Eu anomalies. Whole-rock and zircon Dy/Yb ratios showed no correlation with whole-rock Rb/Sr ratios and zircon Hf contents, reflecting limited effects of crystal fractionation. The Ba/La ratios were also high (>150), but the Sr/Y and La/Yb ratios were low (Sr/Y < 50; La/Yb < 15). These features likely indicate that the quartz porphyry was generated by water-fluxed melting without differentiation. The rhyolite porphyry and biotite granite shared many geochemical similarities, denoting a unified source. The high La/Yb (>30) but low Sr/Y (<20) ratios and apparent negative Eu anomalies indicated plagioclase fractionation. Decreased zircon Dy/Yb with increasing Hf concentrations reflected noticeable amphibole fractionation. These two suites had fairly low Ba/La ratios. These data together point toward an identical source: dehydration melting of a relatively thickened crust. These melts experienced crystal fractionation after extraction. We propose that the intrusions were generated by the underplating of water-rich mafic magma, which provided both fluid and heat and finally induced two kinds of melting.
Study on deformation control of overlying strata in short-wall coordinated filling mining of thick coal seam under aquifer
Authors: Yao Yinan , Jiang Pengfei , Zhou Nan , Du Erbao
Published: January 2023

The mining of coal resources and the protection of water resources are often in opposition, and this contradiction is more prominent in the mining of thick coal seams due to the difficulty of controlling the overburden deformation. Based on the mining conditions of thick coal seam under the main aquifer of a coal mine in the water shortage area of Northwest China, this paper puts forward the short-wall coordinated filling mining (SCFM) of thick coal seam. The stress analysis of the overall structure consisting of the top and bottom plates, coal pillars and filler at each stage of the mining process was carried out, the length of the short-walled working face suitable for this coal mine was derived, and the key parameters for the mining of the three pan areas of the mine were designed. The analysis results show that the sensitivity of the maximum tensile stress in the roof to the length of the working face is better than the filling rate in the case of short-walled working face arrangement. When the design coal mine working face length is 40 m and the filling rate is 95%, the overburden fissure development height can be controlled to 58.45 m after the whole area of three pan area is retrieved. It is verified by the downhole injection method that the requirement of non-conducting aquifer is satisfied after using SCFM. The research in this paper is of great significance to achieve safe and efficient recovery of coal resources and water conservation under strongly water-rich rock formations.
Permeation grouting mechanism of viscous time-varying fluid considering diffusion path
Authors: Wang Hongbo , Dong Lianglin , Zhang Qingsong , Li Zhipeng , Zhang Peiyuan
Published: January 2023

Due to the hidden nature of the grouting project, it has not been possible to get a clear picture of the slurry transport law, and most of the existing permeation grouting theories have ignored the tortuous characteristics of the pore channels of porous media. Based on the fractal theory of porous media and the equation of seepage motion of viscous time-varying Bingham fluid, a theoretical model of permeation grouting with viscous time-varying Bingham fluid is established, and viscosity tests are carried out for C-S slurry to obtain the time-varying equation of viscosity of C-S slurry. A set of permeation grouting simulation experiment device was designed, and the permeation grouting simulation experiment of C-S slurry was carried out to obtain the variation curve of grouting pressure with time under different injection media and different grouting rates. The results show that the grouting pressure considering the diffusion path of the slurry is 0.9–1.1 times of the experimental results, the grouting pressure obtained from the experimental is 0.7–1.2 times of the theoretical value considering the diffusion path, and the calculated value considering the diffusion path agrees well with the experimental value. The theoretical model can provide scientific guidance for field grouting construction.