bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosing an Acute Leukemia From a Necrotizing Ulcerative Gingivitis in The Oral Cavity: a Case Report
Authors: Andriani Dwi , Hermawan Panky
Published: March 2024

Background: Necrotizing ulcerative gingivitis (NUG) is an acute onset of gingival disease, that presents as an acute, painful, and destructive ulceration and inflammation of gingival tissue. This condition is one of the oral manifestations of leukemia in addition to gingival enlargement and spontaneous bleeding, oral ulceration, petechiae, hematoma, and pale mucosa. Case Report: We reported A 50-year-old woman presented with gum swelling, pain, and easy bleeding in the lower jaw gums. The patient often experiences fatigue, spontaneous bruising, dry skin, and hair loss. Extraoral examination revealed bruises on the hand. Intraoral examination revealed swelling, erythematous and ulcerative lesion, tartar, bleeding on probing in the lingual gingiva of lower central incisor teeth, mucosa pallor, and minor petechiae were observed at the buccal mucosa region 47-48. The provisional diagnosis was NUG with suspicion of systemic disorder. Result: A complete blood count was performed which showed anemia, leukopenia, neutropenia, lymphocytosis, and thrombocytopenia. We diagnosed NUG in acute leukemia patients. Conclusion: This case demonstrates the detection of leukemia and its oral manifestations in acute leukemia patient. The patient was referred to the hematologist oncology.
The Use of Rabbits Used to Propagate Human Lice for Research
Authors: Weisbroth Steven H
Published: March 2024

The globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. While the body louse has been adapted for propagation in the laboratory by feeding in vivo on live rabbits, a similar animal model has not been developed for the host-specific head louse. Accordingly, research for treatment and control of the head louse has largely been performed by using laboratory-reared body lice. This review describes methods for the propagation of body lice in the laboratory and outlines at least 4 areas of research that require sufficient numbers of aged body louse cohorts produced in rabbits for use in controlled studies: 1) pediculicide development and resistance, 2) immunity and vaccine potential, 3) endosymbiotic bacteria needed by lice for nutrition, and 4) lice as vectors of human disease. The review concludes with a discussion of several ethical issues involved with the standard method of using unsedated rabbits and recommends consideration of providing sedating anesthetics for rabbits used in louse feeding procedures.
Токсичность и антигипоксическая активность препарата, содержащего комплексное соединение 5-гидрокси-6-метилурацила с N-ацетилцистеином
Authors: Кутлугильдина Г. Г. , Зимин Юрий Степанович , Гимадиева А. Р. , Репина Э. Ф. , Кудояров Э. Р.
Published: March 2024

Показано, что 5-гидрокси-6-метилурацил (5-OH-6-МУ) образует с N-ацетилцистеином (N-АЦ) комплексное соединение состава 1:1, т.е. исследуемые вещества взаимодействуют в эквимолекулярных соотношениях. В интервале 291 – 316 К изучена температурная зависимость константы устойчивости и определены термодинамические параметры процесса комплексообразования. На основании полученных результатов разработана методика синтеза комплекса, содержащего 5-OH-6-МУ…N-АЦ, и изучена его токсичность и антигипоксическая активность. Установлено, что синтезированный комплекс в дозе 500 мг/кг массы тела подопытных животных (мышей) обладает низкой токсичностью и значительно превосходящей антигипоксической активностью, по сравнению с референтными препаратами (5-OH-6-МУ, N-АЦ).
Arabic Language Learning Problems and Solutions at Abu Bakar Ash-Syiddiq Integrated Islamic Junior High School
Authors: Wahyudi Hakmi , Siregar Juwairiyah , Priambodo Thrio
Published: March 2024

Learning Arabic is learning a foreign language, which will cause difficulties for students to learn it because it is not their mother tongue so problems will arise, both linguistic and non-linguistic. This research aims to describe the problems of learning Arabic and the solutions teachers implement to overcome these problems. The research method used is qualitative. The data collection technique is interviews. The results of this research state that linguistic problems in learning Arabic are found in the sound system and microdata. The non-linguistic problems include inadequate learning facilities and insufficient learning time. The solution to this problem is the repetition method so that students can pronounce the sound system correctly, giving five vocabulary words at each meeting, utilizing existing media, applying exciting methods, and implementing Arabic Day. A teacher must try to improve his competence to solve learning problems.

تعليم اللغة العربية هو تعليم اللغة الأجنبية من شأنه أن يسبب صعوبات للطلاب لتعلمها لأنها ليست لغة الأم، لذلك ستكون المشكلات اللغوية والمشكلات غير اللغوية عديدة. يهدف هذا البحث إلى وصف مشكلات تعليم اللغة العربية والحلول التي يطبقها المعلم. طريقة البحث المستخدمة طريقة البحث النوعي. طريقة جمع البيانات مقابلة. نتائج البحث أن المشكلات اللغوية في تعليم اللغة العربية هي نطق الأصوات العربية وقلة المفردات. والمشكلات غير اللغوية هي بواسطة التعلم غير كافية ووقت الدرس ليس كافيا. حلول المشكلات هي تطبيق طرق تكرار نطق الأصوات العربية، حفظ خمس مفردات كل اللقاء، واستخدام الوسائل الموجودة وتطبيق طرق التعليم المناسبة، وتنفيذ اليوم العربي. يلزم معلم اللغة العربية قادر على حل المشكلات.
Design of Internship Student Management Information System with Software Development Life Cycle Approach
Authors: Fakhira Indah Naurah , Derta Sarwo , Musril Hari Antoni , Okra Riri
Published: March 2024

This research is motivated by the absence of an information system concerning the placement of student internships. This is attributed to the diverse backgrounds of students at the H. Agus Salim Institute of Technology and Business (ITB), comprising three different classes. For regular morning students, internship placements can be tailored to their field of study. However, for evening students (regular two) and weekend students (regular three), who are individuals already employed in government institutions and private companies, determining suitable internship locations becomes challenging. This is because the tasks performed in these institutions and companies may not align with the academic disciplines studied by the students during their academic tenure. In the design of this internship information system, the researcher adopts the Incremental model, which is one of the models in the Software Development Life Cycle (SDLC). Functional suitability testing, compatibility testing, usability testing, and validity testing were conducted on the internship management information system. The test results, carried out by one expert, yielded a functional suitability score of 94%, categorized as excellent. The capability test, also conducted by one expert, resulted in a score of 80%, categorized as very good. Usability testing, conducted by seven experts, yielded a score of 80.6%. Validity testing, carried out by three validators, resulted in a score of 0.86, categorized as highly valid.
Designing a Student Violation Point System Based on Telegram Using PHP Programming Language
Authors: Khoirullah Khoirullah , Supriadi Supriadi , Zakir Supratman , Efriyanti Liza
Published: March 2024

This research is motivated by an issue concerning student violations at Tugumulyo State Vocational High School which are still frequently occurring, and the recording of these student violations is manually documented in a student violation logbook, causing difficulties for the guidance and counseling teachers in managing them. Furthermore, parents face challenges in monitoring their children's discipline at school due to the insufficient delivery of information regarding student violation points. Hence, there is a need for a system capable of managing student violation data and providing information to parents regarding their children's discipline in school. This research applies the Research and Development (R&D) model. The R&D model in this research employs the ADDIE model with five stages: Analyze, Design, Develop, Implement, and Evaluate. This product has been tested for validity, practicality, and effectiveness. The results of the product's validity test obtained a score of 0.85, categorized as valid. The practicality test resulted in a score of 0.97, categorized as a very high level of practicality, while the effectiveness test yielded a score of 0.91, categorized as a high level of effectiveness. These research findings demonstrate that the integrated student violation point system through Telegram at Tugumulyo State Vocational High School has been proven to be valid, practical, and effective.
Data Mining Analysis to Predict Student Skills Using Naïve Bayes Method
Authors: Lizar Yaslinda , Firrizqi Alya Sahira , Guci Asriwan , Sunadi Joko
Published: March 2024

The possession of specific skills by students not only has a positive impact on the students themselves but also on the Study Program within a Faculty and the University as a whole. However, Study Programs sometimes face difficulties in determining the skills of numerous students even after they have completed 7 semesters of study. Therefore, a method to extract available data in order to determine student skills quickly and accurately is essential. This research aims to apply a data mining method to predict student skills in the Information Systems Study Program at UIN Imam Bonjol Padang. The study focuses solely on predicting student skills in the fields of data processing and programming. The method employed in this data mining analysis is the Naïve Bayes method. Data will be collected from student course grades related to data processing and programming. The data will be processed using an application and subsequently tested using a Confusion Matrix. The research results indicate that predicting the determination of student skills in the Information Systems Study Program at UIN Imam Bonjol can be achieved using the Naïve Bayes algorithm, which yielded a Naïve Bayes model accuracy of 93%, precision of 81%, and recall of 81%. The obtained model can be implemented in the form of an application to determine decision-making strategies for students.
IMPLEMENTASI MANAJEMEN RISIKO KSPPS ALFA NUSA BARRU KEBUMEN DALAM MEMINIMALISIR PEMBIAYAAN BERMASALAH
Authors: Umam Khotibul
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengidentifikasi faktor timbulnya  pembiayaan bermasalah serta penerapan manajemen risiko dalam upaya meminimalisir pembiayaan bermasalah di KSPPS Alfa Nusa Barru. Metode penelitian dalam penelitian  adalah kualitatif. Subyek penelitiannya adalah Manager serta dua orang dari bagian pembiayaan dan bagian marketing. Teknik pengumpulan data yang dilakukan adalah observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan dengan  mereduksi data, menyajikan data, dan menarik kesimpulan. Penelitian ini menunjukkan hasil seperti faktor penyebab pembiayaan bermasalah meliputi faktor internal dan faktor eksternal. Untuk penerapan manajemen risiko yang dilalukan adalah indentifikasi risiko, penilaian risiko, memonitoring risiko, dan mengendalikan risiko. Berdasarkan eempat langkah manajemen risiko tersebut antara lain yaitu analisis 5C serta pengisian dokumen, pengelompokan atau klasifikasi financing, tindak lanjut anggota, tindak lanjut keuangan dan pemasaran untuk mengingatkan anggota, langkah yang dilakukan untuk menyelesaikan  kredit macet yang dilakukan di KSPPS Alfa Nusa Barru mengatur ulang sumber daya keuangan dan membantu menjual jaminan anggota.
Pengaruh PDRB perkapita terhadap disparitas pendapatan provinsi di Indonesia tahun 2017 - 2021 dalam Perspektif Ekonomi Islam
Authors: Wiza Yerna
Published: March 2024

Penelitian ini bertujuan untuk mengukur pengaruh PDRB Perkapita terhadap disparitas pendapatan provinsi di Indonesia tahun 207-2021 dan untuk menganalisis bagaimana pandangan ekonomi Islam tentang disparitas dan faktor-faktor yang mempengaruhinya. Penelitian ini dilakukan dengan pendekatan kuantitatif menggunakan data sekunder yang diperoleh dari Badan Pusat Statistik Nasional tahun 2017 sampai dengan 2021 menggunakan teknik pengambilan data dokumentasi. Metode analisis data yang digunakan adalah dengan analisis regresi data panel, uji asumsi klasik data panel dan uji kelayakan model regresi dengan bantuan Eviews 12 SV. Pada penelitian ini didapatkan bahwa tingkat PDRB Perkapita (X) berpengaruh negatif terhadap tingkat disparitas pendapatan provinsi di Indonesia (Y). Hal ini dapat dilihat pada hasil uji t yang dilakukan dimana pada kolom uji t didapatkan nilai -3,74146 dan t tabel sebesar -1,97427 yang artinya t hitung lebih kecil daripada t tabel sehingga berdasarkan kriteria pengambilan keputusan maka Ho ditolak. Besarnya pengaruh ini dapat dilihat pada analisis koefisien determinasi (R Squared) yang didapatkan hasil pengaruh tingkat PDRB perkapita terhadap disparitas pendapatan adalah 94,42% yang artinya tingkat PDRB perkapita berpengaruh signifikan terhadap disparitas pendapatan dan sisanya dipengaruhi oleh variabel lain yang tidak diteliti.

Kata Kunci: PDRB Perkapita; Disparitas; Kesejahteraan
Upaya Guru Pendidikan Agama Islam dalam Membentuk Akhlak Siswa
Authors: Iqbal M
Published: March 2024

Abstract

The study of Islamic education teachers' efforts in shaping student morals at MTsN 05 West Pasaman is very important to avoid the many problems regarding student morals that occur in this increasingly sophisticated era, with games on cellphones can change a person in terms of behavior. As well as many events that occur at school about a student who fights or commits acts of violence against the teacher. One of the cases regarding the dilapidation of student morals is the deadly persecution of a fine arts teacher. Through field studies, this research was conducted at MTsN 05 West Pasaman, which is located on Pematang Sontang Street, Sungai Aur District, West Pasaman Regency, West Sumatra Province with a zip code of 26573. The data collection techniques used are observation, interviews, documentation and triangulation or combined. This article suggests how the efforts of Islamic Religious Education teachers in shaping student morals at MTsN 05 West Pasaman. The findings of this study explain that Islamic Religious Education Teachers have efforts in shaping student morals which provide examples or examples, provide advice, enforce discipline, familiarize, provide motivation.

 

Abstrak

Kajian terhadap upaya guru PAI dalam membentuk akhlak siswa di MTsN 05 Pasaman Barat ini sangat penting dilakukan untuk menghindarai banyaknya permasalahan mengenai akhlak siswa yang terjadi di era zaman yang semakin canggih ini, dengan game di handphone dapat merubah seseorang dalam segi berperilaku. Seperti halnya banyak yang terjadi peristiwa di sekolah tentang seorang siswa yang melawan maupun melakukan tindakan kekerasan terhadap guru. Salah satu kasus mengenai bobroknya akhlak siswa yaitu terjadi penganiayaan berujung maut terhadap guru seni rupa. Melalui studi lapangan, penelitian ini dilakukandi MTsN 05 Pasaman Barat yang berlokasi di Jalan Pematang Sontang Kecamatan Sungai Aur Kabupaten Pasaman Barat Provinsi Sumatra Barat dengan Kode pos 26573. Teknik pengumpulan data yang digunakan ialah melakukan observasi, wawancara, dukumentasi dan trianggulasi atau gabungan. Artikel ini mengemukakan bagaimana upaya guru pendidikan Agama Islam dalam  membentuk akhlak siswa di MTsN 05 Pasaman Barat. Adapun temuan penelitian ini menjelaskan bahwa Guru PAI mempunyai upaya dalam membetuk akhlak siswa dimana memberikan Contoh atau Teladan, Memberikan Nasihat, Menegakkan kedisiplinan, Membiasakan,  Memberikan Motivasi.
PERLINDUNGAN HUKUM TERHADAP PESERTA “REMOTE PAID INTERNSHIP” BERDASARKAN HUKUM KETENAGAKERJAAN
Authors: Wijaya Rr. Chantika Vebyola , Waluyo Waluyo
Published: March 2024

Pemagangan merupakan pelatihan kerja yang diselenggarakan oleh suatu perusahaan dengan bekerja langsung di bawah arahan serta pengawasan instruktur atau tenaga yang lebih berpengalaman guna menguasai keahlian tertentu. Tujuan dari penelitian ini untuk mengkaji tentang keberlakuan Undang-Undang Ketenagakerjaan serta peraturan khusus dan serupa mengenai pemagangan. Jenis penelitian yang dipakai ialah penelitian yuridis normatif yang memberikan penjelasan sistematis terkait peraturan, menganalisis hubungan antara peraturan, menjelaskan isu permasalahan hukum. Hasil penelitian didapat kesimpulan bahwa keberlakuan Undang-Undang Nomor 13 Tahun 2003 Tentang Ketenagakernaan serta peraturan khusus dan serupa mengenai pemagangan pada dasarnya tidak mengenal istilah remote paid internship yang diadaptasi dari budaya remote working. Sehingga perlindungan hukum yang diberikan cukup terbatas karena pemerintah belum mengatur secara jelas mengenai remote paid internship. Dalam peraturan yang ada, pemerintah pun belum mengatur mengenai sanksi apabila terdapat pelanggaran dalam kegiatan pemagangan.
Hosts of lung helminth Crenosoma vulpis (Rudolphi, 1819)
Authors: Plieva A. M. , Balayeva R. I.
Published: March 2024

The purpose of the research is to study the species composition of Crenosoma spp. dwelling in the body of wild canines (Vulpes vulpes, Canis lupus, and Canis aureu).

Materials and methods. The research material was 36 wild canines belonging to three species (19 Vulpes vulpes, six Canis lupus, and 11 Canis aureu). The animals were studied using the method of partial helminthological dissections per K. I. Skryabin.  The dissections determined the infection intensity (sp./animal) and prevalence (%).

Results and discussion. We studied pulmonary helminth infections of wild animals in the Republic of Ingushetia. The study results showed a high infection rate in wild carnivores. The average prevalence in the animals was 47.2%. The foxes were the most heavily infected (73.6%); they were found to have two Crenosoma spp., Crenosoma vulpis and C. petrowi. The prevalence was 16.6% in wolf, and 18.2% in jackal.
Bayesian Adaptive Lasso for the Detection of Differential Item Functioning in Graded Response Models
Authors: Shan Na , Xu Ping-Feng
Published: March 2024

The detection of differential item functioning (DIF) is important in psychological and behavioral sciences. Standard DIF detection methods perform an item-by-item test iteratively, often assuming that all items except the one under investigation are DIF-free. This article proposes a Bayesian adaptive Lasso method to detect DIF in graded response models (GRMs), where the DIF effects for all items can be identified simultaneously. The multiple-group GRMs are specified, and the possible DIF effects for each item are reparameterized using the increment components. Then, a Bayesian adaptive Lasso procedure is developed for parameter estimation, in which DIF effects can be automatically obtained. Our method is evaluated and compared with the commonly used likelihood ratio test method in a simulation study. The results show that our method can recover most model parameters well and has better control of false positive rates in almost all conditions. An application is presented using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health).
FUNGICIDAL ACTIVITY OF THE BIOCIDAL DRUG "IODOSAN"
Authors: Buchkovska H , Chechet O. , Kovalenko V. , Vishchur O. , Baranov V. , Zakharin S. , Asanova M.
Published: March 2024

The development of modern effective biocidal remedy for poultry, non-toxic disinfection in the presence of poultry with prolonged effect and sanitizing the air environment is a constant task for scientists. Controling of test cultures of micromycetes is the main indicator of determining the effectiveness of the drug. Various methods are used for this. The results of research on the effect of the biocidal drug "Iodosan" based on lactic acid, iodine, isopropanol demonstrated its fungicidal activity against the reference strains of Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404. It is established that by the method of serial dilutions, using paper discs on the Chapek medium and on agar malt extract under the action of the biocidal drug "Iodosan" was determined to have an effective concentration of 0.75%.

The biocidal drug «Iodosan» in 1.0% concentration after exposure for 60 minutes of effectively disinfected test objects of wood, iron, brick and plaster that were contaminated with micromycetes. It has been proven that the activity of the biocidal drug «Iodosan» depends on the concentration, the duration of exposure, which is why it is important to follow to these regimes when using it.
РЕЖИМИ ОХОЛОДЖЕННЯ І ДЕКОНСЕРВАЦІЇ СПЕРМИ ТВАРИН (Огляд літератури)
Authors: Сушко О. Б. , Жегунов Г. Ф. , Савельєва М. С. , Єлецька Л. М. , Мартинюк I. M.
Published: March 2024

Представлено огляд вітчизняних та іноземних літературних джерел, а також данні опублікованих власних досліджень стосовно режимів кріоконсервування і деконсервування сперми тварин. Осташко Ф. І. вперше було чітко доведено, що повне зникнення рідкої фази в статевих клітинах бугаїв при глибокому заморожувані відбувається за температури мінус 51 оС. Белоус А. М. зі співавторами показали залежність ступеня ушкодження лізосом, мітохондрій і плазматичних мембран сперміїв в залежності від швидкості охолодження. Швидкість на рівні 80 оС/хв. в більшій ступені ушкоджує клітинні структури, ніж 18 оС/хв. У наших дослідженнях на моделі сперми жеребців доведено залежність фізіологічних показників і ступеня ушкодження клітинних мембран від режимів охолоджування. Було застосовано три режими кріоконсервування: швидкий – від 0 до мінус 10 оС зі швидкістю 3 оС/хв; від мінус 10 до мінус 80 оС зі швидкістю 25 оС/хв; прискорений (або середній) – від 0 до мінус 10 оС зі швидкістю 2,5 оС/мин; від мінус 10 до мінус 80 оС зі швидкістю 15 оС/хв; повільний – від 0 до мінус 10 оС зі швидкістю 1 оС/хв; від мінус 10 до мінус 80 оС зі швидкістю 2,5 оС/хв. Було встановлено, що найкращі результати спостерігаються при швидкому методі охолодження. Також нами створено метод заморожування сперми жеребця у шприц- тубах об’ємом 1 мл и 5 мл. Для його реалізації використовується спеціально розроблений термоблок «Кріотроп». У практичній діяльності для відтавання сперми у більшості випадків використовують температуру наближену до температури тіла тварин 35−40 оС. Проте оригінальний метод деконсервації сперми бугаїв був розроблений Бугровим О. Д. і Осташко Ф. І., який полягав у відтаванні сперми в облицьованих гранулах за температури 100 оС. Серією експериментів було доведено, що найкращі фізіологічні показники деконсервованої сперми спостерігаються після витримки облицьованої гранули в окропі протягом 6−7 сек з наступною стабілізацією на повітрі. При цьому отримана середня рухливість сперми на рівні 46−47 % та виживаність 9,0−9,2 год, що достовірно перевищували контроль. У результаті тривалої роботи вчених розроблено режими кріоконсервування сперми тварин, що дозволяють зберігати її необмежений час та отримувати повноцінне запліднення тварин після деконсервації генетичних ресурсів.
APPLICATION OF THE NEXT GENERATION SEQUENCING IN BIOLOGY AND MEDICINE
Authors: Gerilovych A. P. , Sushko M. I. , Mandyhra S. S. , Rodyna N. S. , Romanko M.Ye. , Kuchinskiy M. V. , Gerilovych I. O.
Published: March 2024

Next-Generation Sequencing (NGS), also known as high-throughput sequencing, refers to a set of modern DNA sequencing technologies that have revolutionized the field of genomics. Advantages of NGS techniques involving high speed (parallel sequencing is faster than traditional methods, allowing researchers to obtain results more quickly), cost-effectiveness (ability to sequence multiple fragments simultaneously reduces the cost per base compared to traditional sequencing), and scalability (platforms can be scaled to accommodate varying levels of throughput depending on experimental needs). NGS has significantly accelerated genomics research, enabling breakthroughs in fields such as personalized medicine, cancer genomics, and evolutionary biology. However, challenges such as data analysis complexity, error rates, and cost still exist and are areas of ongoing research and improvement within the field of sequencing technologies. Paper contains the brief explanation of the current NGS platforms and their features. NGS biomedical application is described with the main advantages and abilities of the analysed tools.
МОНІТОРИНГ БРУЦЕЛЬОЗУ СІЛЬСЬКОГОСПОДАРСЬКИХ ТВАРИН ТА ДИКОЇ ФАУНИ НА ТЕРИТОРІЇ УКРАЇНИ ЗА ПЕРІОД 2017–2021 РР.
Authors: Алексеєва Г. Б. , Кравцова О. Л. , Поліщук О. Д. , Метолапова Г. М. , Гераймович В. Л.
Published: March 2024

За даними ВООЗ, у світі щорічно реєструється біля 500 тис. нових випадків захворювання на бруцельоз у людей. Територія України є вільною від бруцельозу сільськогосподарських і свійських тварин. З 1967 р. бруцельоз не реєструвався серед овець, останні 25 років – серед великої рогатої худоби. Серед людей підтверджені поодинокі випадки бруцельозу у приватному секторі через прямий контакт з імпортованими тваринами. Проте, наразі в Україні під впливом сучасних соціально-економічних чинників, міграційних процесів, небезпеки щодо транскордонного занесення інфекції, а також відкриття нових видів бруцел, вивчення їх природних резервуарів, формування осередків хвороби на територіях, раніше вільних від бруцельозу, бруцельоз залишається бути важливою та актуальною проблемою. Оскільки у 2017–2021 рр. були виявлені антитіла до збудника бруцельозу у 20 зразках сироваток крові відібраних від тварин дикої фауни, проблема бруцельозу тварин потребує поглиблених досліджень та продовження моніторингу поширення цієї інфекції з-поміж сприйнятливих видів тварин.
Intrahepatic cholestasis and its correction in patients with chronic acalculous cholecystitis
Authors: Pecherskikh M. V. , Efremova L. I.
Published: March 2024

Functional disorders of the liver in chronic acalculous cholecystitis, manifested by intrahepatic cholestasis, require therapeutic correction. The aim of the study was to assess the functional state of the liver in patients with chronic acalculous cholecystitis and to develop therapeutic approaches to the identified changes. Materials and methods: 123 patients with chronic heart failure were examined on the basis of the gastroenterology department among the patients there were 90 women and 33 men with the duration of the disease from 5 to 10 years. The average age of patients was 43.74±1.26 years. To clarify the effect of cholestasis on the course of chronic acalculous cholecystitis, all examined patients were divided into two groups: patients chronic acalculous cholecystitis with cholestasis and patients chronic acalculous cholecystitis without cholestasis. The group of patients with cholestasis consisted of 84 people, whose average age was 46.46 (32.67; 60.25) years old, 22.62% were men, 77.38% were women. The group of patients without cholestasis consisted of 39 people with an average age of 43, 56 (28.44; 53.68) years, 13 (33.33%) men and 26 (66.66%) women. Results: the clinical course of chronic acalculous cholecystitis is determined by the presence or absence of intrahepatic cholestasis. Dyskinetic disorders of the gastrointestinal tract and the sphincter apparatus of the biliary tract are more common in patients with cholestasis, which in turn is formed against the background of gallbladder abnormalities in the form of various deformities, and leads to intrahepatic bile stagnation, biliary hypertension. Conclusion: the combined use of metronidazole, hemicromone and ademethionine contributes to the resolution of congestion in the intrahepatic bile ducts, normalization of tone and motor function of the gallbladder and sphincter apparatus of the hepatobiliary tract and reduction of clinical manifestations.
The concept of enzymatic disintegration of nutrients in the upper gastrointestinal tract
Authors: Aleynik V. A. , Babich S. M.
Published: March 2024

The aim of the study was to study the effect of salivary amylase on improving gastric protein digestion, as well as the effect of gastric protein hydrolysis on improving fat digestion. The work consisted of two parts, in the first part, in two series, the hydrolysis of proteins under the influence of gastric juice in the presence of starch and the effect of saliva amylase on the change in the total proteolytic activity of gastric juice when using substrates of a mixture of starch and proteins were investigated. In the second part of the work, the lipolytic activity of pancreatic juice with the studied proteins was studied in the presence and absence of bile. From the data obtained, it was found that the use of a mixture of starch with proteins helps to reduce the hydrolysis of proteins by gastric juice. The use of salivary amylase promotes an increase in protein hydrolysis by reducing the formation of starch-protein complexes that prevent the digestion of proteins by gastric juice. All the studied proteins, except gelatin, have an inhibitory effect on lipase in the pancreatic juice; the degree of inhibitory effect of each protein is expressed differently. It depends on their degree of digestion in gastric juice. Thus, the preliminary hydrolysis of proteins by pepsins in the stomach contributes not only to the further improvement of their hydrolysis under the influence of proteolytic enzymes of pancreatic juice, but also to the hydrolysis of fats under the influence of pancreatic lipase. It is concluded that the sequence of nutrient breakdown by enzymes of saliva, stomach and pancreas is primarily aimed at enzymatic disintegration between polysaccharides and proteins, as well as proteins and fats, in order to reduce their interaction and the formation of physical complexes. Thus, secondarily, improve the digestibility of nutrients in the upper gastrointestinal tract. The conceptual assumption of enzymatic disintegration of nutrients in the upper gastrointestinal tract allows us to substantiate the existing sequence of initial digestion of polysaccharides by saliva, as well as the initial digestion of proteins by gastric juice.
Deported Soviet peoples during the Great Patriotic War: historiographical analysis, problems of adaptation
Authors: Isakieva Zulai
Published: March 2024

The article presents a theoretical and historiographical analysis of the problem of a number of peoples forcibly resettled to Altai, Siberia, Kazakhstan, Central Asia as a result of the repressive policy of the Stalinist regime during the war. The author characterizes some aspects of the social adaptation of the deported Soviet peoples in severe, harsh climatic and moral conditions of the special regime. The study of actions in the special settlement of an individual, social, national, age and other groups makes it possible to objectively and comprehensively write the history of the people.
The permanent Russian famine in the 20th сentury: to the question of methodology
Authors: Poliakov Vyacheslav
Published: March 2024

The article based on the idiographic way of knowledge considers methodology for complex development of the problem of the Russian famine that became permanent in the 20th century and analyzes basic components of this research.
The blockade is not for everyone: food, money and textiles from besieged Leningrad
Authors: Sushkov Andrey
Published: March 2024

The article discusses some accusations, which were brought against the defendants of so-called “Leningrad affair". As the documents shows, the Leningrad leadership sent food, textiles to their own families evacuated to the Southern Urals and also supplied them with money during all the siege period. Smolny representatives in Chelyabinsk used material resources taken from Leningrad for personal enrichment. But after Stalin's death the charges against the accused participants were dropped out. The article called into question a validity of Khrushchev's rehabilitation in relation to the defendants of “Leningrad affair".
Nuremberg epilogue: fascism before the court of peace-loving peoples
Authors: Nechevin Dmitry
Published: March 2024

The study is an attempt to show one of the greatest tragedies of mankind of the 20th century the Second World War in the light of today's realities. History knows many examples of cruelty and inhumanity of bloody crimes, but never before have atrocities and atrocities been committed on such a scale as the fascists did in 1941-1945. The article analyzes the history of fascism: its nature, genesis, triumph, defeat, crimes, the verdict of the International Military Tribunal.
Pattern of oro-dental disease in dental clinic of a tertiary care center
Authors: Sharma Bishnu Prasad
Published: March 2024

Introduction: The oro-dental diseases are major public health problem throughout the population in Nepal and other countries of the world. It affects people throughout their lifetime. Unhealthy lifestyles, environment and oral health related behavior are the primary causes of oro-dental diseases. We aimed to study the descriptive variables related to oro-dental dental diseases amongst patients attending tertiary care center.
Method: A three-year data (April 2019 to April 2022) of patients registered for the treatment of oro-dental diseases in the record book of dental department of Patan Hospital were collected retrospectively. The collected data were entered in Microsoft Excel, and statistical analysis was carried out by using Statistical Package for the Social Science (SPSS) version 16.
Result: In the study, 15,879 patients were included; among them 8,652(54.49%) were female and 7,227(45.51%) were male. The most prevalent oro-dental disease was gingivitis/periodontitis 5,076(31.96%) followed by dental caries 5,028(31.66%), abrasion 3,525(22.2%), malocclusion 951(5.99%), impaction 585(3.68%), pulpitis 384(2.42%) and edentulous 330(2.08%). In male, majority 1,800(24.9 %) belonged to 60 years and above age group, in female, majority 1,749 (20.21 %) belonged to 20-29 y.
Conclusion: The most prevalent oro-dental diseases was gingivitis/periodontitis followed by dental caries, abrasion, malocclusion, impaction, pulpitis and edentulous. The female patients had more oro-dental problems than males.
The Effectiveness of Law Enforcement against C Class Mining Permits in East Lombok Regency
Authors: Aryani Renni , HS H. Salim , Wagian Diangsa
Published: March 2024

This research aims to understand and describe the effectiveness of law enforcement against C class mining permits in East Lombok Regency, and to analyze the effectiveness of law enforcement against C class mining permits in East Lombok Regency. This research type in this thesis is empirical law study using Statute Approach, Historical Approach, And Sociological Approach. The effectiveness of law enforcement against c class mining permits in East Lombok Regency. In Permits regulation of C class mining in East Lombok region. In giving Mining Permits, that is no longer be the local government authority, but it goes to Central Government by delegating the Permits to the provincial government according to Act. No. 55 year 2022. The effectiveness of law enforcement against C class mining permits in East Lombok Regency judging from 5 factors, these are regulation, law enforcement, tools and infrastructure, society, and culture. These 5 factors being an indicator of its law enforcement effectiveness. But in this case the law enforcement and society being the problem in this research. It’s because less awareness of the society itself especially in working for this C class mining, the doers/society is not eligible of the administration requirements, did not propose SIPB based the requirement and regulation apply. Also, the lax of law enforcement officials for executing the mining that does not have SIPB Mining Permits).
The Implementation of Conversion of Irrigated Rice Fields into Settlements and its Impacts (Case Study in Labuapi Sub-District, West Lombok)
Authors: Qamariah Nur , HS Salim , Wagian Diangsa
Published: March 2024

This research aims to find out how the implementation of the conversion of irrigated rice fields into settlements in Labuapi Sub-District, West Lombok, analyze the factors that cause the conversion of irrigated rice fields into settlements in Labuapi Sub-District, West Lombok, and analyze the impact of the transfer of irrigated land functions on socio-economic development in Labuapi Sub-District, West Lombok. This type of research is a type of Empirical Legal research. The approaches used are the Statute, Historical, and Sociological approaches. The rapid expansion of the industrial structure has resulted in a large-scale, sustainable conversion of farmland according to Government Regulation of the Republic of Indonesia No. 1 of 2011 concerning the Determination and Transfer of Agricultural Land Functions. Sovereignty belongs to the people, which is also reflected in the concept of human rights to a healthy environment according to Article 28 H Paragraph (1) Constitution of the Republic of Indonesia 1945. Apart from the concept of power and the human right to the environment, the conversion of land is also reflected in the concept of democracy related to the principles of sustainable development and environmental insight, as articulated in Article 33 Paragraph (4) of the United Nations, which is strictly regulated. The influential factors of land conversion rate are, firstly, significantly influential and not yet significantly influential. Social and economic impacts are very diverse and felt by the people of Labuapi Sub-District, West Lombok; the social impact of land conversion can be seen from the relationships and interactions between residents, security conditions, and lifestyle conditions of the surrounding community.
THE ROLES AND RESPONSIBILITIES OF ADIGURU KRAF IN SUSTAINING THE HERITAGE OF MALAY WOOD CARVING WITH RESILIENT PRACTICES
Authors: Kamarudin Zumahiran , Abdul Rahman Julaila , Awang Arita Hanim , Desa Salmiah
Published: March 2024

This paper aims to elaborate on how the roles, responsibilities and good practices can join in the enterprise of sustaining the heritage of Malay wood carving as reflected in the case of Adiguru kraf (master craftsman), Abd. Muhaimin Hasbollah from Temerloh, Pahang. The rationale is that virtues of research in understanding the roles and responsibilities of Adiguru Kraf, through his craft practices in sustaining the heritage of Malay wood carving is relatively novel and vital for recognition. Therefore, the main objective of this research was to identify the key components of his involvements in sustaining the wood carving industry. This is essential as the Malay wood carving is traditionally associated with the making of craft that requires manual skill and craftsmanship, while its production is to exercise skill based on knowledge and experiences. A qualitative interview with Abd. Muhaimin was conducted and it has set out the context of a master craftsman, an inheritor of heritage carving and practices, in relation to his roles and responsibilities that reflect his title as Adiguru Kraf. The investigation has led to the understanding of his characteristics and how he produced his works with some levels of exclusiveness, peacefulness, and purposefulness. The outcome and contribution of the paper is a better understanding of the roles of the master craftsman, which may become inspiration for the younger generation of woodcarvers to excel in their profession. Understanding of his roles in relation to the professional virtues and craft production is essential because of the potential and value of eliciting and transmitting of his knowledge and skill for the development of wood carving craft and industry.
Cost Performance for Residential Building Projects
Authors: Mahamid Ibrahim
Published: March 2024

The construction industry is one of the main sectors that play basic role in the urban and rural development of a society. It provides important ingredients for the development of an economy. However, many construction projects experience extensive cost overrun. This study is conducted to: (1) reveal the magnitude and direction of cost overrun in building construction projects implemented in the West Bank - Palestine over the years 2013 to 2018, (2) develop prediction models for predicting project cost overrun based on the contract price value, (3) identify the causes of cost overrun in building construction contracts in the West Bank â€“ Palestine, (4) test the importance of cost overrun causes from consultants and contractorsâ€™ perspective. To achieve the study objectives, two methods are followed: (1) Field data collection for 102 building construction projects implemented in the West Bank during the period 2013 and 2018, (2) A questionnaire survey was conducted to identify and rank cost overrun causes from the perspectives of contractors and consultants. The findings reveal that100% of projects suffer from cost overrun with average of 34.58%, ranging from 15% to about 88%. The results show that cost overruns for building projects increased with contract prices. The questionnaire survey reveals that the top five cost overrun causes from combined view are: experience in contracts, insufficient time for estimate, incomplete drawings, materialsâ€™ price fluctuation, and political situation. It is hoped that the findings will guide efforts to improve the performance of construction industry in Palestine and other developing countries.
DAYLIGHTING AND VISUAL COMFORT STUDIES OF DESIGN STUDIOS IN FACULTY BUILDINGS
Authors: MOHD ARIFFIN NOOR AZIAH , ELEYAN SABREEN M
Published: March 2024

Daylighting is an effective method in creating a comfortable visual environment and energy efficiency in university buildings. The potential for energy savings through daylighting studies is great was investigated using a case study approach on the three design studios in KAED Building, International Islamic University Malaysia (IIUM). The methodology simultaneously undertook field measurements and opinion surveys in the studios facing north, south, and northwest. Daylighting measurements using the Lux-Meter and calculations of the lighting energy consumption were conducted. The questionnaire survey was distributed to the users of the studios to assess their opinions on visual comfort. The results showed that the lighting levels were not up to the required standard. However, the lack of daylight did not hinder the users' visual comfort. The study proposed changing the existing less-efficient Fluorescent-T8 lamps to the more-efficient LED (light-emitting diode) lights for energy efficiency. Calculations on the annual energy consumption yielded a 40% reduction in the lighting bills and a payback period of around five years.
INVENTORY OF MALAY ARCHITECTURAL HERITAGE IN GOMBAK DISTRICT, SELANGOR
Authors: Salleh Nurul Hamiruddin , Abdullah Mohammad Zaim , Ab Jalil Nurlelawati , Shaharil Muhammad Ihsan
Published: March 2024

Gombak District in the Klang valley contributes considerable importance to the history of Malay settlement which traces back to hundreds of years. This led to the existence of Malay architectural heritage in the Gombak district. Hence, this research seeks to discover the Malay architectural heritage that still retains the Malay traditional features and design identity. The traditional Malay buildings in Gombak were identified and later documented in an inventory form. The research involved a combination of literature review, onsite inventory, and face to face semi-structured interview methods. Thirty-nine (39) Malay traditional houses and masjids from 13 villages in Gombak are identified, which were built more than 80 years while a few were 140 years old. The research also revealed that 35 of the heritage buildings are still sturdy and preserved. Proactive preservation initiatives and conservation efforts need to be carried out immediately to conserve the traditional Malay houses and masjids to be appreciated by future generations.
CARBON EMISSION INTENSITY FOR MELAKA GREEN TECHNOLOGY CITY STATE
Authors: Mustaffa Ts Mohd Hafizam , Zen Irina Safitri , Asmawi M. Zainora
Published: March 2024

The study analyzes the carbon emission absolute number and intensity for Melaka state as a response to the Malaysia voluntary reduction target of up to 40 percent in terms of emissions intensity of gross domestic product, GDP by the year 2030 compared to 2005 levels. It is manifested in the vision of Melaka Green Technology city state by 2020. The Global Protocol for Community-Scale Greenhouse Gas Emissions, GPC method deploys to calculate greenhouse gas, GHGs emission resulted from the various development activity in Melaka. This method classified GHG emissions into four (4) mains sectors: stationary energy, transportation, waste, and agriculture, forestry, and other land use (AFOLU) by using secondary data from related government agencies at the state level. The computation by BASIC+ reporting level resulted from an output of GHGs emission translated into carbon emission. Steady increase of GHG emissions was captured from 8,859,802 tCO2e (2013) to 8,911,173 tCO2e (2017). Further, carbon emission intensity calculates by gathering the carbon emission absolute number to Melaka’s population. The emission per-capita increase from 6.19 tCO2e (2013) to 6.88 tCO2e (2017), indicates each person contributes to the increment of GHGs emissions for Melaka state. However, the decrease of emission intensity records from 0.189 tCO2e (2013) to 0.176 tCO2e (2017) compared to an increase in population growth. The study concludes certain influences of the aggressive green technology initiative effect, such as renewable energy, LED street lighting, solar valley, smart metering in the building, electric public bus, no plastic bag, waste recycling to the overall carbon emission intensity of Melaka Green technology City State.
AN INVESTIGATION ON SUSTAINABLE REFURBISHMENT PRACTICE OF BUILDING WORKS IN MALAYSIA
Authors: Mohd Sopery Luqman Hakim , Ayob Mohd Fairullazi
Published: March 2024

Refurbishment is one of the solutions to address the environmental issues that the construction industry is currently facing. Even though so many existing buildings have gone through refurbishment works, many of the buildings still lack consideration to incorporate sustainable elements. Realizing that sustainable refurbishment is one of many ways to solve environmental problems, this research aims to address major barriers faced by the construction players and develop strategies to improve the practice of sustainable refurbishment of existing buildings, specifically in the Malaysian context. Semi-structured interview approach was conducted with six selected practitioners who are dependable to give their perspectives on this research area. The result of the analysis established that the lack of clients’ requirements and high upfront costs has been established as the main problems in the implementation of sustainable refurbishment in Malaysia. Apart from that, the interviewees agreed to the main strategies: strengthening the Government's regulations, elevating the company’s image, and reducing the operational cost of sustainable refurbishment works.