bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence Methods in Predicting the Productivity of Project Teams: Transhumanism and Experience in Practical Research
Authors: FEDOTOVA Marina , KOZLOVA Elena , BÌN Yin
Published: May 2022

The article considers issues related to the use of artificial intelligence methods in the technoscience concept while moving from personnel management to human resource management using artificial intelligence elements. Authors consider the development of human resources at the expense of cognitive-communicative resources of personnel in specific (transformed) conditions of consciousness when a synergy of neurocognitively enhanced human capabilities and artificial intelligence occurs. Such situations are considered in predicting the productivity of project teamwork, characterized by various aspects: organizational, cognitive-communicative, socio-psychological, etc. It is analyzed a specific example of predictive analytics related to the assessment of future results of newly created teams (shift teams) and results that are corrected based on already existing teams (V. K. Finn’s DSM-method of automatic hypotheses generation, as a way to organize knowledge using the non-Aristotelian structure of concepts, 2009). Some difficulties of using the shift form of labour organization are considered. The methodology for predicting the teams’ assessment is based on the results of express diagnostics of their work on specific test cases and the general database of characteristics and results already existing successful and unsuccessful teams.
On Identification, Identity, and Security Issues in Modern Armenia
Authors: ATOYAN Vardan , OHANYAN Sofya , MALKJYAN Arpine , MOVSISYAN Nane
Published: May 2022

In the current era of constant change, it is necessary not so much to rely on the past with its value system but to surmise the development tendencies of the civilization and clarify one’s place and role. In the modern world, it is a shift of identification crisis followed by identity crisis as values change due to the global economy, creating a consumer character for whom identification and identity issues are secondary. A human strives to be in a security zone where a free-market economy and better living and working conditions are possible.
The authors of the article aim to propose and substantiate the idea that the above-mentioned makes the observation of security, identification, and identity issues in Armenia relevant.
The following methods have been used parallelly during the study: general-worldview, dialectical, general-scientific (of analysis, combination, comparison, and systematic, logical and historical), private-scientific, and descriptive.
The authors have concluded that the achievements that withstood the test of time should be preserved while upgrading the national identity in modern Armenia. The Armenian society should be transformed with the right measured steps priorly. Afterwards, the transformation of political institutions will proceed more naturally and properly.
Observabilidad y diseño de observadores no-lineales en producción de biocombustibles
Authors:   , Flores Mejía Hilario
Published: May 2022

Uno de los mayores obstáculos para el diagnóstico, monitoreo y control de bioprocesos es la ausencia de sensores para la medición de variables clave que tengan las siguientes características: (i) en línea, (ii) confiables, (iii) no intrusivos, (iv) esterilizables, y (v) con buenas propiedades de robustez. Las variables clave en la mayoría de bioprocesos incluyen la carga orgánica, las especies de microorganismos, las concentraciones de metabolitos o productos intermedios y las velocidades de reacción. En la literatura se han propuesto los sensores suaves u observadores de estados para la estimación de estados no medibles en una gran cantidad de bioprocesos. Un observador de estados es un sistema dinámico que reconstruye estados no medidos de un sistema con base a un modelo dinámico del sistema y de las mediciones disponibles. Un análisis previo al diseño del observador es la propiedad de observabilidad, la cual se ha estudiado usando diferentes aproximaciones. Sin embargo, la más común es la que se basa en el criterio de observabilidad con base a una linealización del modelo original en un punto de operación dado, por lo general en los puntos de equilibrio del proceso. En la actualidad estas técnicas se han complementado con otras técnicas de diferentes áreas, como los diagramas de inferencia. Existe una gran cantidad de diseño de observadores, tales como los observadores clásicos de Luenberger y filtros de Kalman que garantizan convergencia asintótica de los estados estimados a los reales considerando un modelo perfecto y que se cumple la propiedad de observabilidad en su aproximación lineal. Para tratar con incertidumbres del modelo se han propuesto extensiones o modificaciones a los observadores anteriores, así como otras propuestas tales como observadores difusos, adaptables, y de tipo modo deslizante. El interés de este proyecto de investigación doctoral es profundizar en el estudio de la observabilidad y el diseño de los observadores más adecuados para bioprocesos en producción de biocombustibles. En particular, la investigación se centra en tres aspectos: (i) El análisis de observabilidad no-lineal con base a diferentes enfoques reportados en la literatura. (ii) La variabilidad de las propiedades de la observabilidad en diferentes regiones de operación. (iii) La aplicación de diferentes técnicas de estimación de estados a diferentes casos de estudio. Debido a su relevancia e interés actual, la clase de bioprocesos considerados son los biocombustibles, sin embargo, las metodologías y resultados reportados se espera que sean aplicables a una amplia clase de bioprocesos.
Embedding Landscape in the Education of Young Planners
Authors: Ray Karen
Published: May 2022

Understanding the relationships between a development and its wider setting is not new to planning. This often delicate balance has been contemplated by planners since well before the ground-breaking European Landscape Convention emerged in 2000. Nevertheless, and in the sustainable management of change, the ELC and its interpretations in domestic laws serve as conscious reminders of landscape as being more value-laden and complex than mere scenery. They support arguments for why meaningful engagement must and should be done - arguments that are most compelling during the education of young planners. In a world where rapid environmental change leads to more deadlines for decision-makers, and in which approaches to prescriptive environmental standards can result in mediocre compliance, it might seem idealistic to expect engagement with landscape in this way. Sharing experiences from University College Cork, this paper explores methods for equipping students with the skills necessary to make efficient and objective yet value-sensitive judgements on landscape at strategic and project levels.
Pathology in Practice
Authors: Herrmann Ina , Nagel Jonathan , Luff Jennifer , Traverson Marine , Murphy K. Marcia , Linder Keith E.
Published: May 2022

In collaboration with the American College of Veterinary Pathologists
Penerapan Aplikasi SLiMS 9 versi Bulian Untuk Mewujudkan Katalog Elektronik di Perpustakaan SMAN 1 Cicalengka
Authors: Rabani Silfi , Rukmana Evi Nursanti , Rohman Asep Saeful
Published: May 2022

Penelitian ini bertujuan untuk mengetahui sistem katalogisasi yang diterapkan di perpustakaan SMAN 1 Cicalengka. Hal ini dilatarbelakangi karena pandemi Covid-19 telah melanda seluruh dunia selama hampir dua tahun. Semua aspek kehidupan terus berjuang agar tetap bertahan ditengah pandemi virus Covid-19 sehingga kehidupan terus berjalan. Perpustakaan sebagai lembaga penyedia informasi juga melakukan hal ini. Meski ditengah pembatasan sosial, perpustakaan harus tetap melayani para pemustaka sehingga dapat terus memenuhi kebutuhan informasi. Pemanfaatan teknologi menjadi sangat penting dan dapat menjadi solusi dalam memberikan layanan pemustaka dimasa pandemi Covid-19. Metode penelitian yang digunakan adalah penelitian kualitatif deskriptif, pengumpulan data dilakukan dengan wawancara. Hasil penelitian menunjukkan bahwa perpustakaan SMAN 1 Cicalengka belum menerapkan otomasi dan katalogisasi elektronik di perpustakaan. Hal ini disebabkan karena perpustakaan belum memiliki SDM yang mendukung untuk melaksanakan katalogisasi dan otomasi. Tidak adanya staf lulusan ilmu perpustakaan menjadi salah satu alasan belum diterapkannya otomasi perpustakaan dan belum adanya katalog elektronik. Dengan melakukan penelitian ini, penulis berharap dapat memberikan solusi bagi para pustakawan di SMAN 1 Cicalengka sehingga dapat melakukan otomasi perpustakaan dan dapat mewujudkan katalogisasi elektronik dengan memanfaatkan aplikasi SLiMS 9 versi Bulian. Application of the Bulian version of the SLiMS 9 Application to Create an Electronic Catalog at the Library of SMAN 1 Cicalengka. This study aims to determine the cataloguing system applied in the library of SMAN 1 Cicalengka. The Covid-19 pandemic has hit the whole world for almost two years. All aspects of life continue to struggle to survive amid the Covid-19 virus pandemic, so life continues. Libraries as information providers also do this. Even amid social restrictions, libraries must continue to serve their users to continue to meet their information needs. The use of technology is crucial and can be a solution in providing user services during the Covid-19 pandemic. The research method used is descriptive qualitative research, data collection is done by interview. The results showed that the library of SMAN 1 Cicalengka had not implemented automation and electronic cataloguing in the library. The library does not yet have human resources to support cataloguing and automation. The absence of library science graduates is one of the reasons why library automation has not been implemented, and there is no electronic catalogue. By conducting this research, the authors hope to provide a solution for librarians at SMAN 1 Cicalengka to automate the library and realize electronic cataloguing by utilizing the Bulian version of the SLiMS 9 application.
Analisis Similarity/Kemiripan Artikel Jurnal Online Terbitan Tahun 2019-2020 Di ISI Yogyakarta
Authors: Agustiawan Agustiawan
Published: May 2022

Penelitian ini bertujuan untuk mengetahui tingkat similarity/ kemiripan artikel jurnal online terbitan tahun 2019-2020 di ISI Yogyakarta. Hasil penelitian ini dapat menjadi bahan evaluasi bagi penerbit jurnal, bagi para penulis/author artikel jurnal, dan para penentu kebijakan di ISI Yogyakarta. Penelitian ini menggunakan metode tes yang digunakan untuk menguji tingkat similarity/ kemiripan pada artikel jurnal online di ISI Yogyakarta dengan aplikasi turnitin. Untuk mengukur tingkat similarity/ kemiripan artikel jurnal online di ISI Yogyakarta ditetapkan rentang skala pengukuran berdasarkan presentase (0-100%) dari nilai similarity. Penulis menetapkan sampel penelitian dari artikel yang diterbitkan 23 jurnal online di ISI Yogyakarta yang terbit periode tahun 2019 sampai dengan 2020. Hasil penelitian menunjukkan bahwa artikel jurnal online di ISI Yogyakarta yang terbit pada tahun 2019 ada 256 artikel dan yang terbit pada tahun 2020 ada 251 artikel. Dari artikel tahun 2019 dan 2020 diambil nilai rata-ratanya tertinggi 76,92% pada tingkat similarity 1-24% atau kategori Low degree of similarity. Berdasarkan nilai tingkatan ini dapat disimpulkan bahwa artikel jurnal online di ISI Yogyakarta yang terbit pada tahun 2019 dan 2020 mempunyai tingkat similarity rendah.  Similarity Analysis/Similarity of Online Journal Articles Published in 2019-2020 at ISI Yogyakarta. This study aims to find the similarity/similarity of online journal articles published in 2019-2020 in  ISI  Yogyakarta. The results of this study can be evaluation material for journal publishers, authors /authors of journal articles, and policymakers at ISI Yogyakarta. This study used a test method to test similarity levels in online journal articles in ISI Yogyakarta with the Turnitin application. To measure the similarity/similarity level of online journal articles in ISI Yogyakarta, set a range of measurement scales based on the percentage (0-100%) of similarity values. In this study, the authors determined the study sample was an article published in 23  online journals ISI Yogyakarta published in 2019 to 2020. From the research results,  it is known that articles in online journals in ISI Yogyakarta published in 2019 were 256 articles and published in  2020  there were 251  articles. From 2019 and 2020, if taken, the highest average value is 76.92% at the similarity level of 1-24% or the Low degree of similarity category so that based on the value of the level ini, it can be concluded that online journal articles in ISI Yogyakarta published in 2019 and 2020 have low similarity  rates.
Perpustakaan Sebagai Tempat Rekreasi Informasi
Authors: Endarti Sri
Published: May 2022

Perpustakaan merupakan tempat penyimpanan ilmu dan informasi. Peran dan fungsi perpustakaan adalah ikut mendorong kemajuan dan peningkatan kecerdasan masyarakat. Fasilitas dan sarana perpustakaan dapat mendorong kreativitas, menambah wawasan, serta dapat digunakan sebagai tempat wisata ilmiah. Wisata informasi di perpustakaan selain menambah pengetahuan juga dapat memberikan kesenangan bersifat menghibur. Tulisan ini membahas peran dan fungsi perpustakaan sebagai tempat rekreasi informasi. Libraries as Information Recreation Area. The library is a place to store knowledge and information. The role and function of the library are to participate in encouraging the progress and improvement of people's intelligence. Library facilities and facilities can promote creativity, add insight, and be used as a scientific tourist spot. Information tours in the library, in addition to increasing knowledge, can also provide entertaining pleasure. This paper discusses the role and function of the library as a place for information recreation.
Kelekatan, resolusi konflik, dan kepuasan hubungan berpacaran pada dewasa muda: Model analisis jalur
Authors: Kalamsari Nurrahma Sukmaya , Ginanjar Adriana Soekandar
Published: May 2022

Pola kelekatan merupakan salah satu faktor individual yang secara konsisten ditemukan memengaruhi kepuasan hubungan. Resolusi konflik yang konstruktif juga terbukti dapat meningkatkan kepuasan hubungan. Meski pengaruh kedua faktor tersebut terhadap kepuasan berhubungan telah didukung oleh studi-studi mandiri, studi ini bertujuan untuk mengevaluasi secara komprehensif peran dari kedua faktor itu melalui analisis jalur. Oleh karena itu, penelitian ini berfokus untuk melihat bagaimana pengaruh antara dua pola kelekatan (anxious attachment dan avoidant attachment) dan resolusi konflik (keterlibatan konflik, perilaku positif, dan perilaku menghindar) terhadap kepuasan hubungan berpacaran pada dewasa muda dengan menggunakan analisis jalur (path analysis). Terdapat 824 partisipan dewasa muda (18-36 tahun; Musia = 21.6; SD = 2.54) dalam penelitian ini. Hasil penelitian menunjukkan bahwa anxious attachment, avoidant attachment, dan resolusi konflik secara signifikan berpengaruh terhadap kepuasan hubungan. Penelitian ini menggambarkan bahwa pola kelekatan dan resolusi konflik merupakan faktor penting dalam menjaga stabilitas dan kepuasan hubungan.
Studi Eksperimental Tekanan Jaringan Perpipaan
Authors: Rahma Siti Hardiyanti
Published: May 2022

Tekanan aliran adalah salah satu faktor penting dalam pengaliran air dalam pipa. Bila tekanan rendah, maka akan menimbulkan masalah dalam pendistribusian jaringan pipa. Namun bila tekanan terlalu besar akan menyebabkan kehilangan energi. Selain itu, dalam instalasi jaringan pipa akan terjadi hambatan aliran yang disebabkan faktor-faktor instalasi jaringan pipa itu sendiri seperti kecepatan aliran, perubahan dimensi pipa dan adanya belokan, serta perubahan kekasaran material pipa. Hambatan aliran akan menyebabkan turunnya energi dan tekanan.Tujuan penelitian ini yaitu menganalisis seberapa besar pengaruh paraemeter aliran terhadap tekanan dalam jaringan perpipaan dan mendapatkan hubungan parameter tak berdimensi pada jaringan perpipaan. Penelitian ini menggunakan penelitian eksperimen yang dilaksanakan di laboratorium Hidrolika Departemen Teknik Sipil Fakultas Teknik Universitas Hasanuddin di Gowa. Karakteristik sampel air yang digunakan adalah density (ρ) 1.000 kg/m3, viskositas kinematik 0,804 x 10-6 m2det, viskositas dinamik (µ) 0,801 x 10-3 Nd/m2, nilai viskositas (kekentalan) 8,5x10-7 m2/det, dan berat jenis (y) 1,00355 gr/cm3, serta suhu 29,50C. Variase debit yang digunakan ada 3 yaitu Q1= 0,004 m3/det, Q2 =0,003m3/det dan Q3 = 0.002 m3/det serta variasi tinggi jatuh (head) H1 = 0,5 meter, H2 = 1 meter dan H3 = 2 meter.  Hasil penelitian menunjukkan bahwa pengaruh parameter aliran terhadap tekanan dalam jaringan perpipaan bahwa semakin tinggi debit maka tekanannya juga meningkat. Hal ini disebabkan karena kecepatan dan Bilangan Reynold juga meningkat. Sedangkan pengaruh headloss, semakin tinggi headloss maka tekanan semakin rendah karena semakin jauh titik pengamatannya sehingga terjadi kehilangan energi (mayor losses dan minor losses). Hubungan parameter non dimensional dari semua parameter menunjukkan hubungan yang sangat signifikan antara P dari hasil pengukuran dan P empiris.
Optimasi Layanan Air Baku dan Irigasi Embung Kawari Kabupaten Jeneponto
Authors: Amin Muh Nur asri
Published: May 2022

Abstrak

Perencanaan pembangunan Embung Kawari untuk mengatasi keterbatasan sumber air yang ada di Kecamatan Bontoramba, Provinsi sulawesi Selatan. Embung tersebut digunakan untuk memenuhi kebutuhan air baku dan irigasi. Pemenuhan layanan embung perlu dioptimasi untuk memenuhi jumlah kebutuhan air baku dan irigasi dengan berbagai skenario. Penelitian ini dilakukan dengan tujuan menentukan jumlah pemakaian air untuk kebutuhan air baku dan irigasi secara optimal. Optimasi dilakukan dengan metode Generalized Reduced Gradiant (GRG). Untuk fungsi tujuan memaksimalkan penggunaan air embung.Hasil optimasi diperoleh dua kriteria, kriteria A pemanfaatan air untuk air baku sebesar 42% dari proyeksi penduduk di tahun 2029 dan areal layanan irigasi untuk tanaman padi seluas 316,13 Ha dan tanaman jagung 63,87 Ha, kriteria B pemanfaatan untuk air baku sebesar 42% dari proyeksi penduduk di tahun 2029 dan areal layanan irigasi pada tanaman jagung seluas 697,35 Ha.

 

Abstract

Optimization of raw water and irrigation services for kawari dam, Jeneponto Regency. Kawari dam construction design to overcome the limitations of water resources in Kecamatan Bontoramba, South Sulawesi. The Dam is used to comply raw water needs and irrigation. The fulfillment of raw service requirements optimization to fulfill the amount of raw water in vary scenarios. This research aims to determine the amount of water usage for raw water and irrigation needs optimally. The optimation performed with Generalized Reduced Gradiant (GRG) Methods. For the purpose of its function is to maximize the dam water usage. The optimization results obtained two criteria, Criterion A The use of water for raw water is 42% of the estimated population in 2029 and the irrigation service area for rice plants is 316.13 Ha and corn 63.87 Ha, Criterion B utilization for raw water is 42% from the estimated population in 2029 and the corn crop irrigation service area is 697.35 Ha.
Studi Eksperimental Kecepatan Aliran Slurry pada Saluran Tertutup
Authors: Akbar Muhammad Taufiq
Published: May 2022

Dalam suatu aliran yang melewati sistem atau instalasi jaringan pipa air limbah akan terjadi hambatan aliran yang disebabkan oleh faktor-faktor instalasi jaringan pipa itu sendiri seperti perubahan kecepatan, perubahan penampang (dimensi pipa, belokan, sambungan) dan perubahan kekasaran permukaan. Hambatan aliran akan menyebabkan turunnya energi dan tekanan. Sape (2016) menguraikan sumber dari self head loss dan limit deposit velocity (DHLLDV) berdasarkan konsentrasi volume dan ukuran butiran partikel seragam yaitu (1) kehilangan energi pada regime fixed atau stationary flow yang di sebabkan oleh turbulensi aliran bed; (2) kehilangan energi pada regime slidding bed yang di sebabkan oleh slidding friction benda padat pada dinding pipa; (3) kehilangan energi pada regime heterogeneous akibat energi potensial (gravitasi) dan energi kinetik (tumbukan benda padat dengan dinding pipa); (4) kehilangan energi pada regime homegen disebabkan oleh turbulensi partikel besar; (5) kehilangan energi pada regime slidding yang disebabkan oleh slidding friction, energi potensial dan energi kinetik.. Tujuan penelitian ini yaitu untuk mendapatkan besaran pengaruh parameter aliran slurry terhadap regime aliran pada pipa lurus dan pipa belok. Pengambilan data primer secara analisis kuantitatif dengan pengumpulan data utama melalui pengukuran dengan mengunakan rangkain pipa sebagai model pengujian, serta didahului dengan pengumpulan data pendukung yaitu analisis karakteristik sampel air. Karakteristik sampel air yang digunakan adalah density (ρw) 1.000 kg/m3, density padatan (ρs) 2.670 kg/m3 viskositas kinematik 0,804 x 10-6 m2/det, viskositas dinamik (µ) 0,801 x 10-3 Nd/m2, nilai viskositas (kekentalan) 8,5x10-7 m2/det, dan berat jenis (y) 1,00355 gr/cm3, serta suhu 29,5 oC. Variasi debit yang digunakan ada 3 yaitu 0,004 m3/det, 0,003m3/det, dan 0,002 m3/det serta tinggi jatuh (head) 0,5 meter. Air yang mengandung partikel padat atau sedimen (slurry) yang mengandung sedimen seragam berupa pasir dengan ukuran 0,15 mm, 0,25 mm dan 0.42 mm
Estimasi Biaya Disposal PET 97 DP Menggunakan Metode High and Low Di Pt Vale Indonesia Tbk, Kabupaten Luwu Timur, Sulawesi Selatan
Authors: Ikram Muhammad Abdi Dzil
Published: May 2022

Abstrak

Disposal area merupakan sebuah lokasi pada sebuah tambang terbuka yang digunakan untuk menyimpan sementara waste rock atau overburden yang dihasilkan selama proses pengupasan. Di PT Vale Indonesia terdapat tiga tipe disposal yang digunakan, yaitu induce flow, semi-induced flow, dan finger flow. Penelitian dilakukan pada disposal PET 97 DP dengan jenis disposal semi-induce flow. Disposal ini dikerjakan menggunakan dua unit dozer CAT D8R sebagai alat utama, dan civil material serta material pembatuan untuk meningkatkan stabilitas disposal. Disposal PET 97 DP termasuk jenis disposal semi-induced flow dengan empat dumping point dan memiliki tonase sebesar 919.484,363 ton dengan total kebutuhan civil material sebesar 321.819,527 ton. Estimasi biaya civil material dilakukan menggunakan metode high-low dan menghasilkan total estimasi biaya mencapai $1.186.777,53. Disposal PET 97 DP diperkirakan dapat digunakan hingga 12 minggu dengan target produksi 75.000 ton/minggu dengan menggunakan dua unit dozer. Total biaya yang dibutuhkan dalam pengoperasian disposal PET 97 DP diperkirakan mencapai $1.450.513,50.

 

Abstract

Disposal area is a location in an open pit mine that were used to temporarily keep waste rock or overburden that were produced during the stripping process. In PT Vale Indonesia, Tbk there were three types of disposal that were used, those are induce flow, semi-induced flow, and finger flow. This research was done at PET 97 DP disposal with the type of the disposal being semi-induced flow. This disposal was done using two units of CAT D8R dozers as the main equipment and civil material as the petrification materials to increase the stability of the disposal. PET 97 DP disposal is a semi-induced flow disposal with four dumping points and capacity of 919.484,363 ton with the needs of 321.819,527 ton of civil materials. Civil material cost was estimated using high-low method with the total cost was $1.186.777,53. PET 97 DP disposal was expected to be used for 12 weeks with production target of 75.000 ton/week using two units of dozers. The total operation cost that was needed for PET 97 DP disposal was estimated to reach $1.450.513,50.
Kajian Kebutuhan Material Pada Konstruksi Lambung Kapal Phinisi
Authors: Alamsyah Alamsyah
Published: May 2022

Bulukumba merupakan daerah di Sulawesi Selatan yang memproduksi kapal kayu dengan bentuk chiri khas tersendiri. Bahan utama yang digunakan dalam pembuatannya adalah kayu. Ketersediaan material kayu merupakan salah satu variabel yang mempengaruhi harga pembuatan kapal, selain hanya bisa didapatkan dari luar daerah, jumlah material kayu relatif terbatas dengan adanya larangan penebangan liar yang sangat merusak hutan Indonesia. Minimnya bahan alternatif sebagai bahan utama pembuatan kapal kayu menuntut para pengrajin untuk cermat dan efisien dalam penggunaan kayu. Oleh karena itu sangat penting dilakukan kajian kebutuhan material kayu dalam pembuatan kapal kayu. Metode statistik digunakan dalam pengambilan sampel data konstruksi kapal dan metode analitis digunakan dengan memanfaatkan rumus simpson dalam menghitung bentuk dan volume konstruksi kapal kayu yang tidak beraturan sehingga kebutuhan material secara akurat diketahui. Hasil yang didapatkan semakin besar kapasitas kapal kayu maka kebutuhan material kayu pada lambung kapal semakin meningkat, dengan efisiensi material berbanding lurus dengan besar kapasitas kapal.

Bulukumba merupakan daerah di Sulawesi Selatan yang memproduksi kapal kayu dengan bentuk chiri khas tersendiri. Bahan utama yang digunakan dalam pembuatannya adalah kayu. Ketersediaan material kayu merupakan salah satu variabel yang mempengaruhi harga pembuatan kapal, selain hanya bisa didapatkan dari luar daerah, jumlah material kayu relatif terbatas dengan adanya larangan penebangan liar yang sangat merusak hutan Indonesia. Minimnya bahan alternatif sebagai bahan utama pembuatan kapal kayu menuntut para pengrajin untuk cermat dan efisien dalam penggunaan kayu. Oleh karena itu sangat penting dilakukan kajian kebutuhan material kayu dalam pembuatan kapal kayu. Metode statistik digunakan dalam pengambilan sampel data konstruksi kapal dan metode analitis digunakan dengan memanfaatkan rumus simpson dalam menghitung bentuk dan volume konstruksi kapal kayu yang tidak beraturan sehingga kebutuhan material secara akurat diketahui. Hasil yang didapatkan semakin besar kapasitas kapal kayu maka kebutuhan material kayu pada lambung kapal semakin meningkat, dengan efisiensi material berbanding lurus dengan besar kapasitas kapal.
SEJARAH PRAKTEK PERBANKAN SYARIAH
Authors: Agustin Hamdi , Armis
Published: May 2022

Praktek-praktek konsep bank syariah seperti menerima titipan harta, meminjamkan uang untuk keperluan konsumsi dan untuk keperluan bisnis dengan sistem syariah, serta melakukan pengiriman uang, telah lazim dilakukan sejak masa Rasulullah SAW. Tujuan penelitian ini membahas sejarah praktek perbankan syariah, dengan menelusuri praktek-praktek perbankan yang dilakukan oleh umat muslim sepanjang sejarah. Untuk mencapai tujuan penelitian ini, paper ini dibagi menjadi lima bagian yang di jelaskan secara singkat. Penelitian ini menemukan bahwa praktek perbankan yang sesuai dengan syariah sudah ada dimasa Rasulullah SAW, masa Khulafaur Rasyidin, masa Bani Umayyah dan Bani Abbasiyah namun belum berbentuk lembaga komersial. Setelah jatuhnya Bani Abbasiyah praktek perbankan lahir dari Italia karena kata teknis 'bank' berasal dari kata Italia 'banco' yang berarti meja atau bangku yang digunakan penukar uang Italia untuk menampilkan uang dan catatan mereka serta melakukan transaksinya.
Modelling Flavour Release through Quantitative Structure Property Relationships (QSPR)
Authors: Taylor Andrew J. , Linforth Robert S.T.
Published: May 2022

The use of QSPR to explain the partition behaviour of flavour compounds in different matrices and to predict dynamic flavour release from certain food systems is described. QSPR has been applied in the pharmaceutical and environmental areas to predict properties like the efficacy of
drugs (with different substitutions) or behaviours like the accumulation of pollutants in fish, despite the fact that the exact mechanisms are unknown. QSPR relies on the fact that the physicochemical properties of the molecules are responsible for their behaviour and properties in these systems.
The models are relatively easy to produce but there are limitations associated with their use outside the defined experimental conditions. The background to modelling flavour partition and release is given, along with examples of relevant QSPR models.
PENELURUSAN RUANG KORIDOR KOTA DALAM PRODUKSI RUANG SOSIAL TEMPORAL
Authors: Damayanti Rully , Redyantanu Bramasta Putra
Published: May 2022

Dinamika suatu kawasan kota dapat memberikan dampak pada pola pemanfaatan lahan, termasuk guna ruang sebuah jalan dari ruang pergerakan menjadi ruang sosial. Perubahan pola ini menunjukkan adanya isu temporalitas pada fenomena pemanfaatan ruang publik yang tidak terpikirkan sebelumnya. Artikel ini melakukan studi tentang produksi ruang sosial pada ruang koridor kota di Tunjungan, Surabaya. Kerangka teoritis yang dipakai pada penelitian ini adalah pemahaman ruang yang terbentuk karena faktor sosial, tidak hanya fisik. Melalui metode observasi lapangan yang mendalam, diilustrasikan bagaimana sebuah ruang jalan dapat menjadi cerminan dan praktek produksi ruang sosial terkait isu temporalitas. Melalui studi ini juga diusulkan pengembangan desain sebagai tanggapan arsitektural yang dapat mewadahi kedinamisan ruang kota. Temuan dari penelitian ini menunjukkan adanya potensi yang besar terhadap ruang ruang non aktivitas, seperti koridor jalan, sebagai ruang terjadinya interaksi sosial dalam kehidupan kota melalui elemen-elemen kota yang temporer. Masyarakat tidak hanya menghasilkan hubungan sosial dan nilai guna, tetapi dengan berbuat demikian juga menghasilkan sebuah ruang sosial.TRACING THE CITY CORRIDOR SPACE IN THE PRODUCTION OF TEMPORAL SOCIAL SPACEThe dynamics of a city area can impact land-use patterns, including the spatial use of an urban corridor, which transforms from a movement area to a social space. That pattern transformation shows a temporality issue in public space, which was not thought of before. This article conducts a study on the production of social space in urban corridor spaces in Tunjungan, Surabaya. The theoretical framework used in this research is an understanding of space formed due to social factors, not just physical. An in-depth field observation method illustrates how a street space can be a reflection and practice of producing social space related to the issue of temporality. Through this city study, it is also proposed to develop an architectural design that can accommodate space dynamics. The findings of this study indicate that there is excellent potential for non-activity spaces, such as road corridors, as spaces for social interaction to occur in city life through temporary city elements. Society not only produces social relations and use-values but, by doing so, also produces a social space.
Qualitative Analysis of Real Drug Evidence using DART-MS and the Inverted Library Search Algorithm
Authors: Sisco Edward , Appley Meghan G. , Tennyson Stephen S. , Moorthy Arun S.
Published: May 2022

Chromatographic-less mass spectrometry techniques like direct analysis in real time mass spectrometry (DART-MS) are steadily being employed as seized drug screening tools. However, these newer analytical platforms require new computational methods to best make-use of the collected data. The inverted library search algorithm (ILSA) is a recently developed method designed specifically for working with mass spectra of mixtures collected with DART-MS, and has been implemented as a function in the NIST/NIJ DART-MS Data Interpretation Tool (DIT). This paper demonstrates how DART-MS and the ILSA/DIT can be used to analyze seized drug evidence, while discussing insights gathered during the evaluation of several adjudicated case samples. The evaluation verified that the combination of DART-MS and the ILSA/DIT can be used as an informative tool to help analysts screen seized drug evidence, but also revealed several factors an analyst must consider while employing these methods—all of these considerations are summarized in this paper.
Design and optimization of Oestrogen Receptor PROTACs based on 4-hydroxytamoxifen
Authors: Loren Guillem , Espuny Irene , Llorente Alicia , Donoghue Craig , Verdaguer Xavier , Gomis Roger , Riera Antoni
Published: May 2022

In the last four decades, treatment of oestrogen receptor positive (ER+) breast cancer (BCa), has focused on targeting the estrogenic receptor signaling pathway. This signaling function is pivotal to sustain cell proliferation. Tamoxifen, a competitor inhibitor of oestrogen has played a major role in therapeutics. However, primary and acquired resistance to hormone blockade occurred in a large subset of these cancers, and new approaches were urgently needed. Aromatase inhibitors and receptor degraders were approved and alternatively used. Yet, resistance appears in the metastatic setting. Here we report the design and synthesis of a series of proteolysis targeting chimeras (PROTACs) that induce the degradation of estrogen receptor alpha in breast cancer MCF-7 (ER+) cells at nanomolar concentration. Using a warhead based on 4-hydroxitamoxifen, bifunctional degraders recruiting either cereblon or the Von Hippel Lindau E3 ligases were synthesized. Our efforts resulted in the discovery of TAM-VHL-1, a potent ERα degrader (DC50: 4.5 nM) that we envisage as a useful tool for biology study and a platform for potential therapeutics.
One-Pot Two-Step Catalytic Synthesis of Rationally Designed 6-amino-2-pyridone-3,5-dicarbonitriles Enabling Anti-Cancer Bioactivity
Authors: Nicely Lynden G , Vala Ruturajsinh M , Upadhyay Dipti B , Nogales Joaquina , Chi Celestine , Banerjee Sourav , Patel Hitendra M
Published: May 2022

Herein we report a one-pot two-step synthesis of a bioactive 6-amino-2-pyridone-3,5-dicarbonitrile derivative using natural product catalysts betaine and guanidine carbonate. Upon identification of the anticancer bioactivity of the compound, we carried out structure-activity relationship and rationally designed a library of 16 derivatives. Out of the compounds, 5o had the most potent anti-cancer activity against murine glioblastoma cell lines and was selected for further study. Compound 5o showed anti-cancer properties against liver, breast, lung as well as primary patient-derived glioblastoma cell lines. Furthermore, 5o in combination with specific clinically relevant brain-penetrant small molecule inhibitors induces enhanced cytotoxicity in a murine glioblastoma cell line. Through our current work, we establish a promising 6-amino-2-pyridone-3,5-dicarbonitrile based lead compound with anti-cancer activity either on its own or in combination with specific clinically relevant small molecule kinase and proteasome inhibitors.
Transition State Spectroscopy of the F + NH3 Reaction
Authors: Babin Mark , DeWitt Martin , Lau Jascha , Weichman Marissa , Kim Jongjin , Song Hongwei , Guo Hua , Neumark Daniel
Published: May 2022

Transition state spectroscopy experiments based on negative ion photodetachment directly probe the vibrational structure and metastable resonances that are characteristic of the neutral reactive potential energy surface (PES). Here, we study the five-atom reaction F + NH3 → HF + NH2 using slow photoelectron velocity-map imaging spectroscopy of cryogenically cooled FNH3¯ anions. Reduced-dimensional quantum dynamical simulations performed on a global potential energy surface show excellent agreement with the experimental results, allowing for the assignment of spectral structure and demonstrating that key dynamics of this bimolecular reaction are well described by this theoretical framework. Our combined experimental-theoretical study reveals features associated with a manifold of vibrational Feshbach resonances in the product well of the F + NH3 PES. At higher energies, the spectra reveal structure attributed to resonances localized across the transition state and into the reactant complex well, which may impact the bimolecular reaction dynamics.
Modeling Hydrocarbons Adsorption in Amorphous Nanoporous Carbonaceous Materials
Authors: Corrente Nicholas , Hinks Elizabeth , Kasera Aastha , Gough Raleigh , Ravikovitch Peter , Neimark Alexander
Published: May 2022

Predicting adsorption on nanoporous carbonaceous materials is important for developing various adsorption and membrane separations, as well as for oil and gas recovery from shale reservoirs. Here, we explore the capabilities of 3D molecular models of disordered carbon structures to reproduce the morphological and adsorption features of practical adsorbents. Using grand canonical Monte Carlo simulations, we construct a series of adsorption isotherms of simple fluids (N2, Ar, CO2, and SO2) and a series of alkanes from methane to hexane on two model 3D structures, purely microporous structure A and micro-mesoporous structure B. We show that structure A reproduces the morphological properties of commercial Norit R1 Extra activated carbon and demonstrates outstanding agreement between the simulated and experimental adsorption isotherms reported in the literature for all adsorbates considered. Good agreement is also found for simulated and measured isosteric heats. Taking into account inherent variability of structural properties of commercial carbons and experimental adsorption data from different literature sources, the correlations with experiments are truly amazing. This work provides a new insight into the specifics of structural and adsorption properties of nanoporous carbons and demonstrates the advantages of using 3D molecular models for predicting adsorption hydrocarbons and other chemicals by MC simulations.
Diffusion coefficient measurement inconsistency as a parameter to monitor structural conformational changes in biomolecules
Authors: Chakraborty Subhayan , Pandey Shalini , Ghosh Arindam
Published: May 2022

Residue specific measurement of translational diffusion coefficient involving labile amide protons of a protein molecule is known to give inconsistent result due to multiple solute-solvent exchange events during the diffusion encoding period. The residues accessible to solvent often overestimates the diffusion coefficient due to the contribution by fast diffusing solvent molecules to the measured values. It has been, however, shown that this apparent drawback of overestimation can become a valuable source of information about the exchange rates. An associated exchange related drawback that has never been perceived in a similar positive manner is the high repetition inaccuracy. The exchanging residues not only overestimate, they do so in an inconsistent way as the contribution of exchange differs from one measurement to the next. We show here how measurement uncertainty can become another useful tool in recognizing the sections of the polypeptide chain that are exposed to solvent. Additionally, we show that the uncertainty is more sensitive a marker than the overestimation in detecting small changes in solvent accessibility of a residue due to structural changes of a protein molecule.
Zirconium-Catalysed Hydrosilylation of Esters and Depolymerisation of Polyester Plastic Waste
Authors: Donnelly Liam , Kobylarski Marie , Berthet Jean-Claude , Cantat Thibault
Published: May 2022

Schwartz’s reagent, Cp2Zr(H)Cl, has traditionally been used as a stoichiometric reagent for the reduction of unsaturated organic molecules. Recently, methods to use Cp2Zr(H)Cl as a catalyst have been developed through turnover of the Zr–X intermediates, formed upon reaction with an organic substrate, with hydride reagents. Herein, we report the development of a new catalytic pathway for the reduction of esters that uses the bench-stable silane Me(OMe)2SiH (DMMS) as a mild stoichiometric reductant and Cp2Zr(H)Cl as the catalyst. This system exploits the regeneration of Zr–H through the sigma bond metathesis of Zr–O and Si–H to achieve catalyst turnover. These reaction conditions tolerate a range of reducible functional groups (e.g. alkyne, alkene, and nitro) and give high yields of the corresponding alcohol (up to 91% isolated yield). We have also applied this methodology to the reductive depolymerisation of polyesters found in household plastic waste.
Hoarseness evaluation and prosthetic rehabilitation after maxillofacial surgery: A clinical report
Authors: Hattori Mariko , Murase Mai , Sumita Yuka I
Published: May 2022

After maxillofacial surgery, some patients have not only articulation disorder, but also voice disorder. It is important for prosthodontists to know what kind of speech disorder patients have so that they can plan and implement rehabilitation. This report describes the case of a 58-year-old man with a speech disorder that developed after mandibulectomy, maxillectomy, neck dissection, and reconstructive surgery because of tumor. Objective evaluation of voice and articulation clarified that the postoperative speech disorder was due to not hypernasality but hoarseness. Conventional postoperative prosthodontic rehabilitation was performed using a delayed surgical obturator and definitive obturator and his voice was objectively analyzed at each stage. The voice disorder improved over time and the results of the voice evaluation helped the prosthodontist to further plan and implement postoperative prosthodontic rehabilitation. (Int J Maxillofac Prosthetics 2021;4:43-46)
Surface electromyography and mandibular motion recording input in prosthetic rehabilitation of segmental mandibulectomy: The MAC2 protocol
Authors: Destruhaut Florent , Rignon-Bret Christophe , Dubuc Antoine , Pomar Philippe , Hennequi Antonin , Combadazou Jean-Claude , Naveau Adrien
Published: May 2022

Lateral segmental mandibulectomy can be associated with sequelae, such as mouth opening limitation and mandibular deviation, that lead to altered oral functions (chewing, swallowing, speech) and complex prosthetic management. The authors present a new protocol for surface electromyography (sEMG) and mandibular motion recording to help clinicians with decision-making and dental prosthetic treatment planning for segmental mandibulectomy. The clinical case of a patient with a reconstructed titanium endoprosthesis is presented. The MAC2 protocol is used and consists of chronologically performing various recordings by using a device for sEMG and mandibular tracking. During the orofacial reeducation and dental prosthetic reconstruction, three therapeutic steps can benefit from the MAC2 protocol: to analyze the initial muscular imbalance, to provide guidance in the choice of maxillomandibular relationship and to quantify the functional improvement. sEMG of masticatory muscles is a useful diagnostic tool in a context of mandibular kinematic disorders and the MAC2 protocol adds some guidance for dental prosthetic rehabilitation in the context of segmental mandibulectomy. (Int J Maxillofac Prosthetics 2021;4:47-54)
The Diverse Roles of Monoclonal Antibodies in Cancer Immunotherapy and Their Relative Effectiveness: A Literature Review
Authors: Ives Rowan , Hwang Kyobin
Published: May 2022

Introduction: In modern oncology, immunotherapy has emerged as a promising treatment modality for numerous cancers. At the forefront of personalized medicine, immunotherapy utilizes components of a patient's immune system to selectively target cancer cells. Numerous immunotherapy drugs have been developed thus far, including monoclonal antibodies (mAbs). mAbs are genetically identical protein antibodies often isolated and purified from animals through recombinant DNA technology. They are capable of recognizing molecules that are uniquely present on the surface of cancer cells, such as tumour-specific antigens and/or receptors. This narrative review explores the various uses of mAbs in the treatment of cancer. Methods: A narrative literature review was conducted using Pubmed, Medline, and Embase to analyze and synthesize current and prior research surrounding the various uses of mAbs in the context of cancer treatment. Specific examples and potential shortfalls of various treatment methods were also analyzed.
Results: mAbs can be used in several distinct ways to target cancerous cells. In the native immunoglobulin G form, mAbs direct immune cells to tumours and induce cytotoxicity by initiating biochemical cascades, leading to effects such as phagocytosis, opsonization, activation of immune cells, degranulation, and cytokine release, among others. mAbs may also be conjugated with radionuclides, or traditional chemotherapeutic agents for targeted drug delivery. They can also be used to target the immune system via conjugation to cytokines or other mAbs which directly interact with immune cells for targeted recruitment. mAbs targeting immune checkpoints can also be used to enhance cancer-related immune responses. However, mAbs are not perfect, and are thus prone to a slew of limitations which are still being addressed.
Discussion: mAbs are highly useful, primarily as a result of their specific molecular recognition abilities. This property underlies all uses in cancer immunotherapy and can further be exploited in the development of new immunotherapy technologies and methodologies, along with the elucidation of novel antigens and targets in cancers, to improve the field and address limitations.
Conclusion: This literature review aims to synthesize data pertaining to the various potential uses of mAbs in cancer treatment. This approach will provide more insight into the current state of immunotherapeutics, and where additional research must be conducted.
Visual Experiment Results (About the 2021 Nobel Prize in Economic Sciences)
Authors: Voronov Yu. P.
Published: May 2022

The article is devoted to analysing the achievements of the laureates of the Nobel Prize in Economic Sciences in 2021. The author described the methods of natural experiment used by the laureates in their research. Further, the author noted the differences between different types of experiments: laboratory, field, computer and mental (thought, imaginary). The author described details of two of their studies (which have become classic) on the consequences for the labour market of the influx of immigrants and the increase in the minimum wage. The methods and results of the laureates’ research on assessing the consequences of state programs and structural decisions are also analysed. In conclusion, the author considered new experimental and econometric research methods, which the laureates have significantly improved. In particular, it concerns the method of counter samples and an example from the author’s research using this method.
The Possibility of Identifying Alpha-Companies by Statistical Methods on the Example of the ExpressLogistics Market In Russia
Authors: Vertogradov V. A.
Published: May 2022

The article attempts to evaluate the use of the conventional statistical apparatus to identify alpha companies in the Russian express logistics market. According to the theory of economic dominance, Alpha-companies occupy dominant positions in industry markets due to access to the cheapest resources and institutional advantages that allow them to build barriers to other players. Identification of such companies has traditionally been carried out by an expert method, including based on insider information, not available to external market players. The author describes the traditional tools used to identify the dominant market players [concentration indices (CR), Lind (L) and Herfindahl-Hirschman (HHI)], made calculations based on official statistics, data from open ratings and other available benchmarks for the express delivery industry in Russia, as well as a comparison with the results of determining alpha companies by an expert method. The author formulated hypotheses to explain the reasons for situations when companies with dominant capabilities are not interested in realizing their potential in a small market. Additionally, the author used some assumptions about the role of institutions regulating the market in case of sharp changes in market conditions.