bluuebunny/crossref_metadata_2025 huggingface dataset:
EXTRACTION OF FLAVONOIDS FROM THE LEAVES OF THE LITTLEWALE LITHOSPERMUM OFFICINALE L. (BORAGINACEAE) USING MICROWAVE ENERGY
Authors: Adamtsevich Natal'ya Yur'yevna , Feskova Elena Vladimirovna , Boltovsky Valeriy Stanislavovich , Titok Vladimir Vladimirovich
Published: March 2021

One of the possible ways to intensify and increase the efficiency of extraction of biologically active substances from plant materials is the use of microwave radiation. This article presents the results of a study of the influence of parameters of the microwave extraction process on the output of flavonoids from the leaves of the littlewale (Lithospermum officinale L.), belonging to the Boraginaceae family. This plant contains isoquercitrin, which is one of the key flavonoids with the property of tissue regeneration. It was shown that the maximum yield of the target components is achieved with a microwave generator power of 100 W and exposure duration of 2.5 min at a field frequency of 2450 MHz (specific energy consumption is 8.4 kWh/kg). This output is comparable with the output when using conventional convection heating. Microwave radiation provides a 16-fold reduction in the duration of extraction of the sum of flavonoids and an increase in the degree of extraction of isoquercitrin by 23%. The action of microwave energy leads to the destruction of plant tissue, which contributes to a more efficient extraction of flavonoids from plant raw materials.
ECDYSTEROIDS AND FLAVONOIDS OF SILENE GRAEFFERI
Authors: Filonenko Elena Sergeyevna , Zibareva Larisa Nikolayevna
Published: March 2021

In this paper Silene graefferi Guss. is recommended for the first time as a promising source of flavonoids and is a well-known producer of ecdysteroids. This perennial species is adapted to the conditions of Western Siberia and has been successfully cultivated in the Siberian Botanical garden of TSU since 2015. It was interesting to study the composition and features of accumulation of biologically active substances during the growth and development of S. graefferi. It was shown that 20-hydroxyecdysone and polypodine B are present in the aerial and underground parts of introduced in culture S. graefferi plants during the entire vegetative development. An unidentified ecdysteroid was detected in the aerial part at the beginning of the vegetation and in the roots during the flowering phase. During vegetative development, common flavonoids and characteristic ones at different periods of plant development were found. The phase of maximum accumulation of ecdysteroids and flavonoids of S. graefferi is the beginning of vegetation, and the minimum is flowering. In the age dynamics the highest levels of biologically active substances in plants were noted at 2 and 3 years of life, then there is a general tendency to decrease with the age of the plant. From the aerial part of S. graefferi, 20-hydroxyecdysone, polypodine B and vitexin were isolated and identified by HPLC.
OPTIMIZATION OF PROCESS FOR PRODUCTION OF NANOCRYSTALLINE CELLULOSE AND ITS COMPOSITES
Authors: Ioelovich Michael Yacob
Published: March 2021

In this work, optimal and waste-free technologies were proposed for the production of nanocrystalline cellulose (NCC) and its composites with inorganic pigment, as well as semi-finished products containing aggregates of nanoparticles. The following optimal hydrolysis conditions were found: concentration of sulfuric acid 40 wt%, temperature 80°C, duration 1 h, acid/cellulose ratio 7. After hydrolysis stage, the hydrolyzed cellulose was washed, diluted with water and disintegrated to isolate individual nanoparticles. Then, the diluted NCC dispersion was evaporated to obtain a commercial product - concentrated NCC paste. In order to obtain a composite, the acid in the unwashed hydrolyzed cellulose was neutralized with calcium hydroxide to precipitate a white pigment, calcium sulfate. In addition, the spent acid and acidic washings were collected and treated with hydroxylapatite (HAP) to produce a valuable by-product, superphosphate (SUP), the sale of which significantly reduces the cost of the primary product, NCC. Contaminated water collected after washing, neutralization and evaporation was purified and returned to the technological cycle. To reduce the cost of production, such expensive process steps as disintegration and evaporation of diluted dispersion were eliminated, which made it possible to obtain cheap semi-finished products containing NCC aggregates or composite of NCC with inorganic calcium sulfate particles.
COMPONENT COMPOSITION OF THE BIODEGRADATION PRODUCT OF FALLEN LEAVES BY BASIDIOMY-CETES PLEUROTUS PULMONARIUS (STRAIN PP-3.2)
Authors: Mamaeva Ol'ga Olegovna , Isaeva Elena Vladimirovna , Loskutov Sergey Redzhinal'dovich , Plyashechnik Mariya Anatol'yevna
Published: March 2021

Today, plant waste, including fallen poplar leaves (litter), are a promising raw material for the production of useful products using bioconversion, such as protein feed additives.

The aim of this study was to study the component composition of the products obtained as a result of the bioconversion of leaf litter. The strain PP-3.2 Pleurotus pulmonarius (Fr.) Quél. In the process of substrate conversion, strain PP-3.2 primarily utilizes extractives and easily hydrolyzable polysaccharides, the amount of which decreases by 44 and 36%, respectively. The total content of polysaccharides is reduced by 20%, lignin substances - 9.4%. The loss of substrate mass based on leaf litter was 23%. The product obtained after cultivation contains 28% protein. Analysis of the amino acid composition of the protein showed a high rate of phenylalanine with tyrosine (115), threonine (117.5), valine (110) and isoleucine (105%). Also, the biodegradation product has a high content of glutamic and aspartic acids (11.2 and 25.3% of the total amino acids, respectively). The levels of cadmium, lead and copper revealed as a result of studies do not exceed the maximum permissible concentrations established by the veterinary department. At the same time, there is a high content of iron (166.0 μg/kg) and zinc (256.7 mg/kg) in the feed product. The digestibility of the product is 54%, the content of nucleic substances is up to 0.3%.

Thus, the results obtained show the possibility of using the product of the conversion of poplar fallen leaves as a protein feed additive.
EFFECT OF TREATMENT WITH PREPARATIONS CONTAINING HUMIC ACIDS ON THE OIL CONTENT AND FATTY ACID COMPOSITION OF BRASSICA NAPUS L.
Authors: Smol’nikova Yana Viktorovna , Velichko Nadezhda Aleksandrovna , Bopp Valentina Leonidovna , Kolomeitsev Aleksandr Vladimirovich , Stutko Oksana Valeriyevna , Khanipova Vera Aleksandrovna
Published: March 2021

The article analyzes changes in the fatty acid composition of spring rapeseed represented by Trapper and Siberian varieties after their treatment with «Huminatrin» and «Beres-8». The fatty acid composition of spring rapeseed cultivated in the Siberian region was studied by gas-liquid chromatography. The rapeseed contains 19 fatty acids with a chain length of 12 to 24 carbon atoms. The treatment with preparations containing humic acids caused different reactions in varieties. The Trapper variety showed a decrease in oil content after processing, while the Siberian variety showed an increase in oil content. It was found that treatment with «Huminatrin» and «Beres-8» caused an increase in linoleic and linolenic acids and a decrease in oleic fatty acids. The maximum content of linoleic and linolenic fatty acids was observed in seeds after their treatment with the «Huminatrin». Also the treatment with «Huminatrin» and «Beres-8» preparations of Trapper and Siberian varieties led to an increase in the concentration of limited fatty acids.
Szolgáltató központok Magyarországon
Authors: Szabó Zsolt Roland , Vida Gábor
Published: March 2021

A szolgáltató központok (Shared Service Center – SSC) mintegy 15 éve jelentek meg Magyarországon, és jelenleg mintegy ötven működik hazánkban. Népszerűségük töretlen, és az üzleti szféra mellett a közszolgálatban is megjelenőben vannak (Ulbrich, 2003). A szolgáltató központok létrehozásának indítékairól és módjáról számos tanulmány született (Arthur Andersen, 2000; PwC, 2006), azonban tényleges működésükről kevés információval rendelkezünk mind hazai, mind nemzetközi szinten. A szerzők tanulmányukban a szolgáltató központokra vonatkozó, másodlagos forrásokból származó megállapításokat, 21 Magyarországon működő központ vezetőitől gyűjtött elsődleges adatokkal tesztelték. Az alapadatok Vida Gábor (2008) e tárgyban született MBA-diplomamunkájához készített kutatásából álltak rendelkezésre. A szerzők a jelen cikk összeállításához az adatokat tovább vizsgálták, összefüggéseiben is továbbelemezték. A tanulmány jelentős eredményének tekinthető, hogy a szolgáltató központok valós helyzetképét sikerült felvázolni a célok, tevékenységek, szervezeti működés és felelősségek, valamint a telephely-választás dimenzióiban. Sikerült azonosítani az SSCvezetők gondolatait meghatározó folyamatos hatékonyság- és minőségjavítási motivációt, az emberek és a rendszerek fejlesztésének eltérő növekedési szemléletét és a túlzott nemzetköziesedés csapdáit.
Lehet akciókutatásból doktorálni? – Eszményképek kontra valóság
Authors: Grasselli Nóra Ilona
Published: March 2021

Ez a cikk egy akciókutatás-alapú doktori disszertáció tanulságait összegzi. Az akciókutatás definiálása után a szerző megvizsgálja, hogy mi indíthat arra egy PhD-hallgatót, hogy ezt a „módszert” alkalmazza. Ezt az ideálképet saját akciókutatásának tapasztalataival összevetve olyan szervezési, módszertani és tudományos kérdéseket vizsgál, amelyek mérlegelése elengedhetetlennek tűnik a doktori akciókutatás elkezdése előtt.
A kartellek szerepe a verseny alakulásában (2006–2007)
Authors: Bara Zoltán
Published: March 2021

A dolgozat segítségével az olvasó képet kaphat a hatóságok által feltárt kartellek elemzése révén a kartellek szerepéről, illetve még közvetettebben, abból az attitűdből, illetve annak változásaiból, ahogyan a versenyhatóságok a kartellek ellen próbálnak fellépni, és ezenközben szigorúbb eszközöket vetnek be a felderítés hatékonyságának javítása érdekében, vagy éppen fordítva. A kartellekkel szembeni versenyhatósági fellépés változásából következtetni lehet a kartellek szerepére is.
Corynespora cassiicola in soybean seeds – incidence and transmission
Authors: Goulart Augusto César Pereira , Utiamada Carlos Mitinori
Published: March 2021

The fungus Corynespora cassiicola, causal agent of target spot in soybeans, has been considered, from the seed pathology point of view, a seed-borne pathogen of limited importance. Therefore, little importance has been given to the role of the seeds in the transmission of this pathogen. The objectives of this study were to determine the incidence of C. cassiicola in soybean seeds and evaluate the effects of this seed-borne pathogen, inoculated in the seeds, in relation to physiological and epidemiological parameters. The experiments were carried out at TAGRO and Embrapa Western Agriculture under lab (blotter test and seed germination test) and greenhouse conditions (growing on test). The fungus C. cassiicola was detected in 11.3% of the 639 seed samples analyzed, with an average incidence of 0.91% and maximum of 8.5%. The transmission of C. cassiicola from the seeds to above-ground parts of soybean seedlings was demonstrated, by pathogen establishment on the cotyledon, showing circular lesions with concentric rings, reddish-brown in the center and surrounded by a yellowish green halo, as a typical symptoms of target spot. Reddish-brown lesions on the roots and stem of the seedlings were also observed. Considering a sample seed with 66.0% of C. cassiicola incidence, the symptomatic transmission based on cotyledon symptoms was 42.2%, corresponding to a transmission rate of 2.4:1. This is the first report, in a quantified way, about the transmission of C. cassiicola from the seeds to above-ground parts of soybean seedlings. When compared to non-inoculated seeds, seed germination, seedling emergence and seedling initial development were influenced by the presence of the pathogen in the seeds, with the lowest values being observed when the seeds were inoculated.
Metabolic characterization and oil profile of sunflower cultivars cultivated with increasing nitrogen doses
Authors: Rocha Janiélio Gonçalves da , Alves Luiziene Soares , Tavares Orlando Carlos Huertas , Stark Elvia Mariam Lis Martinez , Fernandes Manlio Silvestre , Castro Rosane Nora , Santos André Marques dos , Souza Sonia Regina de
Published: March 2021

Sunflower (Helianthus annuus L.) has great economic importance due to its oil yield and quality. Among the factors influencing these parameters, nitrogen fertilization stands out. In this study we evaluated the effect of different N-urea doses (0,10,30,50,90,130 kg N-urea ha-1) at planting and 30 days after emergency on soluble fractions, oil profile and yield of three sunflower cultivars (BRS324, Catissol 01and Neon). Plants were harvested at the flowering stage for metabolic study, and at the end of the cycle for oil extraction and characterization. The Catissol 01 genotype presented the highest N-NO3- accumulation capacity, mainly in the stem. The Neon genotype presented the highest achene production at 30 and 50 kg N ha-1. Oleic oil had the highest yield, with the Catissol 01 and Neon cultivar standing out. Among the cultivars, Catissol 01 is economically more suitable for biofuel production, when cultivated at 50 kg N ha-1 since higher N doses did not result in increased oil yield.
Genetic parameters estimate for plant characters of a particular carrot population in two different agroecologic cultivation systems
Authors: Vilela Michelle Souza , Peixoto José Ricardo , Vieira Jairo Vidal , Silva Giovani Olegário da , Nóbrega Daiane da Silva , Sousa Rosa Maria de Deus de
Published: March 2021

Carrots are among the most planted vegetables in Brazil, which represents importance in the national market. This crop can be grown in conventional and agroecological systems, and studies to improve productivity, disease resistance and root quality in agroecological cropping systems are important. The aim of the present work was to estimate genetic parameters that provide a breeding strategy in the search for the development of new varieties of carrot adapted to the conditions of Distrito Federal’s agroecology cultivation. Considering data from tests performed in areas of agroecology cultivation (Natural Agriculture-NA and Organic Agriculture-OA), the following characteristics were evaluated: incidence of leaf blight-LB, incidence of root cracking-CRACK, root length-COMP, format of root tip-TP, format of root shoulder-TO, measure of the color of the a* xylem parameter-a*X, measure of the color of the a* phloem parameter-a*F. Traits were evaluated in 100 half-sib progenies derived from Brasília cultivar, using a completely randomized block design. For the characters COMP, a*X, a*F, TP and TO, the treatment X environment interaction was significant according to the results from test F. The values of the individual variance analyses presented significant effect for the following characteristics: COMP, a*X, TP, TO, LB for NA system, and COMP, a*X, a*F, TP for OA system. In NA system, the values of heritability estimates-ha² for the plant characters fluctuated from 65.66 to 25.52% and, in the OA system, the ha² of the characters a*X, was 81.13%. Estimates of genetic gain per cycle for the characters a*X and a*F were lower in NA system than the estimates observed in OA system.
Economic study of the cultivation of kale, coriander, lettuce, and chives in intercropping
Authors: Lacerda Rodolfo Rodrigo de Almeida , Oliveira Odair Honorato de , Costa Caciana Cavalcanti , Lacerda Ivislanne de Sousa Queiroga , Luz José Magno Queiroz , Souza Anielson dos Santos , Queiroga Roberto Cleiton Fernandes de , Paiva Laíza Gomes de
Published: March 2021

Intercropping of vegetables in a poorly planned manner may not achieve the expected economic results, as it is an activity that requires a great technical and administrative capacity of the producer. This study aimed to analyze the economic feasibility of intercropping kale with coriander, lettuce, and chives in relation to monocultures. The experiment was conducted in the Center for Agri-food Science and Technology, Federal University of Campina Grande, in the municipality of Pombal, PB in the period from June 2014 to July 2015. Eleven treatments were tested: four polycultures, three bicultives, and four monocultures, in randomized blocks, with four replications.  The productivity, total operating costs (TOC), gross and net revenue, rate of return, profitability index, and efficient land use were evaluated. The TOC values of intercropping were calculated with the prices of July 2015. In all the systems studied, the largest participation was referring to the cost hand of labor. The highest gross and net revenues were observed in the kale with lettuce in bicultive, the rate of return and profitability index was higher on lettuce in monoculture. Despite the increase in the TOCs of the intercropping in relation to the monocultures, the intercropping proved to be economically viable in terms of efficient land use, reaching values indicating a land-use efficiency of up to 50% more in polycultures and bicultives.
Genetic parameters and line selection of Cucurbita pepo based on selection indices
Authors: Beloti Igor Forigo , Maciel Gabriel Mascarenhas , Juliatti Fernando Cezar , Finzi Rafael Resende , Cardoso Daniel Bonifácio Oliveira
Published: March 2021

In the improvement of pumpkins, the selection based on one or a few characters of interest tends to be less efficient, leading to a superior product only compared to the few characters selected. To maximize the simultaneous selection of multiple characteristics of interest, selection indexes are used to obtain a numerical value resulting from the combination of the characters on which the simultaneous selection is to be practiced. The objective of this study was to determine genetic parameters and the most appropriate selection indexes in strains of Summer squash (C. pepo). Statistical analyzes were performed based on 65 genotypes belonging to the vegetable germplasm bank of the Federal University of Uberlândia. The variables analyzed were: leaf area index, precocity, SPAD index, productivity. plant-1, number of fruits. Plant-1, leaf temperature, NDVI index and NDRE index. The indexes were used: Smith (1936) and Hazel (1943), the sum of “Ranks” by Mulamba and Mock (1978), and Willians (1962). The selection methodologies selected ten individuals (15% of the genotypes). The values found for h² (%) ranged from 36.92% (SPAD) to 59.65% (cycle). The values obtained in the CVg / CVe quotient were below 1, varying from 0.18 for leaf temperature to 0.70 for the cycle, with the other variables close to 0.5. The CVg genetic variation coefficient (%) was also low, ranging from 1.84% for leaf temperature to 30.94% for productivity. The greatest gains obtained with direct and indirect selection were for the characters productivity (35.92%), NDRE (33.04%), number of fruits (28.93%) and leaf area index (22.72%). The Mulamba and Mock (1978) index showed the highest total selection gain value, providing a balanced distribution of selection gains, choosing the genotypes: 8, 31, 34, 38, 42, 64, 65, 66, 67 and 68.
Synergistic effects of binary mixtures of linalool with pyrethroids against fall armyworm
Authors: Silva Sérgio Macedo , Cunha João Paulo Arantes Rodrigues da , Zandonadi César Henrique Souza , Assunção Heli Heros Teodoro de , Marques Matheus Gregorio
Published: March 2021

The present work aimed to determine the toxicity of linalool and evaluate the lethal and toxic effects of linalool associated with pyrethroids in binary mixtures to fall armyworm (Spodoptera frugiperda). The insects used in the experiment were obtained from stock breeding initiated from larvae collected from conventional corn plants, grown in an experimental area, in the city of Uberlândia, Minas Gerais. Also, it was obtained essential oil from a variety of Ocimum basilicum, with a high content of linalool (80%), found naturally, as a measure of comparison of different linalool (97.5%) assays. Dose-response bioassays with 3rd instar larvae were performed to determine lethal dose for 50% mortality (LD50) of linalool. Toxicity tests were also performed with O. basilicum essential oil and with pyrethroid insecticides: deltamethrin and its commercial product (Decis 25 EC, Bayer®). After this, combinations between different doses of these products were made and applied on 3rd instar larvae of Spodoptera frugiperda (Smith). Linalool presented high toxicity to S. frugiperda (LD50 = 0.177 μL a.i. μL-1). It was observed neurotoxic effects after the linalool application since the insects presented an aspect of confusion, followed by extreme agitation and finally death. All binary mixtures caused mortality higher than the products applied alone (deltamethrin and linalool) used at 100% LD50, except to 75% LD50 deltamethrin added to 25% LD50 linalool, whose mortality did not differ the products alone, in 24 hours. It was obtained over 90% larval mortality when linalool was combined with 25% LD50 of deltamethrin, in 24 and 48 hours after application, and over 80% of mortality when linalool was combined with 25% LD50 of Decis, only in 48 hours after application. We conclude that linalool is a potential insecticidal and can be associated with pyrethroids to control of S. frugiperda. Further studies are required in order to evaluate the synergistic combinations against field populations of S. frugiperda.
Introduction
Authors: Barbalato Beatrice
Published: March 2021

La plurivocalité est un thème qui a accompagné tous les numéros de Mnemosyne. On peut dire qu’elle est le substrat plus ou moins visible de toute langue et de toute communication orale, écrite, iconographique, et qu’elle remplit plusieurs fonctions. La plurivocalité est l’ADN de notre culture. Une matrice qui a été occultée au profit de l’idée que l’originalité et la subjectivité étaient nos fondamentaux points de repère. La difficulté à reconnaître des composantes plurielles est encore plus grande quand il s’agit d’expressions autobiographiques, subjectives par antonomase. Cependant, à partir surtout du XXe siècle, diverses disciplines, de la philologie à la dramaturgie, à la psychologie et à la psychanalyse, ont élaboré beaucoup d’instruments théoriques pour analyser comment et pourquoi nous devons réfléchir sur la nature polyphonique des expressions individuelles. L’idée qu’une expression culturelle puisse être considérée comme une manifestation purement individuelle est fragile, comme il est fragile de concevoir qu’une langue soit un monopole individuel. […]
An interview with Cauby Maia Chaves Junior
Authors: Furquim Bruno , Dalfabbro Cibele , Bittencourt Lia Rita Azevedo , Rossi Rowdley , Chaves Junior Cauby Maia
Published: March 2021

Cauby Maia Chaves Junior
Biomecânica da correção da mordida cruzada unilateral dentária
Authors: Martins Renato Parsekian
Published: March 2021

INTRODUÇÃO: O tratamento da mordida cruzada dentária unilateral apresenta alguns desafios para o ortodontista. OBJETIVO: O presente artigo se propõe a diagramar, explicar e exemplificar com um caso clínico a utilização da técnica de pressão diferencial aplicada ao ligamento periodontal para o tratamento da mordida cruzada dentária unilateral. CONCLUSÕES: Conclui-se que a estratégia de tensão diferencial aplicada ao ligamento periodontal pode conseguir tratar com êxito a mordida cruzada dentária unilateral sem causar efeitos deletérios ao lado oposto.
A importância da guia anterior imediata: parte 1
Authors: Janson Marcos
Published: March 2021

INTRODUÇÃO: A guia anterior é um dos objetivos mais importantes da Ortodontia, relacionado com a oclusão funcional, estabilidade vertical do tratamento e estética labial. OBJETIVO: O presente artigo tem como objetivo demonstrar, por meio de exemplos, a importância da guia anterior na estabilidade em longo prazo dos casos ortodônticos.
Expansor Mini-Hyrax: uma alternativa versátil para expansão rápida da maxila
Authors: Silveira Giordani Santos , Andrade Ana Luiza Cabral de Ávila , Diniz Amanda Rafaela , Seraidarian Paulo Isaías , Oliveira Dauro Douglas
Published: March 2021

OBJETIVO: O objetivo deste artigo é ilustrar a aplicabilidade do expansor Mini-Hyrax na expansão rápida da maxila (ERM) e na expansão rápida da maxila assistida cirurgicamente (ERMAC). DESCRIÇÃO DO APARELHO: As principais diferenças entre o parafuso utilizado no Mini-Hyrax e aquele do Hyrax são a dimensão anteropos- terior da estrutura e o número de braços. O Mini-Hyrax tem uma dimensão anteroposterior menor (5 mm) e dois braços; enquanto que o Hyrax tem 11 mm e quatro braços. CONCLUSÃO: O Mini-Hyrax pode ser uma alternativa aos aparelhos expansores Haas e Hyrax na ERM e ERMAC com potenciais vantagens de causar menor desconforto e menor dificuldade na higienização devido ao seu tamanho reduzido.
Utilização de miniparafusos na buccal shelf para mesialização de molares inferiores - Parte 2
Authors: Villela Henrique Mascarenhas , Braga Anastácio Barbosa
Published: March 2021

INTRODUÇÃO: A mesialização de molares inferiores de corpo é muito frequente na clínica ortodôntica, devido às agenesias e às perdas precoces de molares ou pré-molares. No entanto, esse movimento ortodôntico é difícil de ser efetuado, devido à necessidade de se controlar a rotação, a angulação e o torque desses dentes durante a sua translação. Essa dificuldade decorre, também, do tipo de osso encontrado na mandíbula, que apre- senta uma cortical com alta densidade e, muitas vezes, com pouca quantidade de osso medular. A introdução da ancoragem esquelética com miniparafusos trouxe muitos benefícios a essa difícil tarefa, simplificando a mecânica ortodôntica, minimizando os efeitos colaterais indesejados, reduzindo a necessidade de colaboração do paciente e tornando os tratamentos mais previsíveis. Contudo, para realizar essa movimentação de forma mais eficiente, fazem-se necessários a compreensão e o domínio da biomecânica aplicada a esses dispositivos. Com a introdução dos miniparafusos extra-alveolares, novas estratégias surgiram para tirar o máximo de proveito desse dispositivo, que fica localizado na buc-cal shelf mandibular. Essa localização permite a livre movimentação sagital dos dentes, devido ao fato de o corpo do parafuso ser posicionado em região mais cortical e afastada das raízes dos dentes. OBJETIVO: O presente artigo apresenta, por meio de um relato de caso clínico, uma estratégia de tratamento capaz de efetuar a mesialização dos molares inferiores diante da perda de um segundo pré-molar, utilizando a ancoragem esquelética com miniparafuso extra-alveolar na região da buccal shelf. CONCLUSÃO: Os três molares inferiores foram mesializados de corpo, de forma eficiente, sem efeitos cola- terais indesejados, com a preservação das estruturas periodontais e obtendo uma boa relação dentária final.
Tratamento da mordida aberta anterior dentoalveolar com colagem indireta digital: relato de caso
Authors: Cunha Taís de Morais Alves da , Vilasboas Gabriel Carlos Fonseca , Barbosa Inessa da Silva , Palma Karolinne Kaila , Carvalho Rodrigo Ferreir , Ribeiro Sérgio Freitas
Published: March 2021

INTRODUÇÃO: A mordida aberta é uma má oclusão com expressivo comprometimento estético-funcional. Pode ter origem dentoalveolar ou apresentar envolvimento esquelético, sendo necessário correto diagnóstico para o adequado manejo clínico. É uma má oclusão de etiologia multifatorial, com elevado potencial de recidiva; entretanto, a abordagem multidisciplinar é capaz de diminuir o risco de instabilidade em longo prazo. OBJETIVO: Relatar o caso clínico de uma paciente adulta portadora de mordida aberta anterior dentoalveolar, no qual foi realizada a colagem indireta digital de aparelho ortodôntico autoligado. DESCRIÇÃO DO CASO: A paciente, com estética facial agradável, apresentava Classe I de Angle com apinhamento moderado, sobressaliência acentuada (7mm) e sobremordida negativa (-4mm), além de arco do sorriso invertido e linha do sorriso baixa. O tratamento foi realizado com expansão das arcadas dentárias e extrusão de dentes anteriores com mecânica de elásticos intermaxilares. RESULTADOS: Foi obtida oclusão mutuamente protegida, com sobressaliência e sobremordida adequadas, o que favoreceu a obtenção de harmonia na estética do sorriso. Não foi necessário acompanhamento fonoaudiológico no período de contenção, pois a paciente não apresentava interposição lingual. CONCLUSÃO: O caso obteve excelente resultado estético e funcional em tempo reduzido de tratamento. A colaboração do paciente, o correto diagnóstico e a realização da colagem indireta digital são fatores que podem contribuir para a eficiência do tratamento ortodôntico.
Tratamento interceptativo de má oclusão de Classe II severa com aparelho extrabucal de Thurow
Authors: Caldas Luciana Duarte , Nigri Anna Paula , Araújo Telma Martins de , Ruellas Antônio Carlos de Oliveira
Published: March 2021

INTRODUÇÃO: O aparelho extrabucal de Thurow é um splint maxilar associado à tração alta bastante efetivo na correção da Classe II, Divisão 1, resultando em alterações anteroposteriores e verticais. OBJETIVOS: O presente relato de caso revisa a aplicação clínica do aparelho de Thurow, descrevendo os efeitos esqueléticos e dentoalveolares na correção de biprotrusão severa. RELATO DE CASO: O paciente encontrava-se em fase de crescimento pré-puberal, com pré-molares em processo de erupção, tendo sido diagnos- ticado com má oclusão esquelética e dentária de Classe II, sobremordida exagerada e sobressaliência acentuada, de 14mm. RESULTADOS: A distalização e intrusão dos dentes superiores foi realizada com sucesso, assim como a contenção do crescimento vertical da maxila, melhorando a exposição gengival, reduzindo o risco de trauma anterior e permitindo o giro anti-horário da mandíbula. CONCLUSÃO: A utilização dessa alternativa terapêutica, em especial durante o surto de crescimento, pode ser de grande valia funcional e estética, quando bem indicada.
Tratamento da mordida aberta anterior em paciente com má oclusão de Classe II de Angle, postura atípica de língua e respiração bucal
Authors: Feu Daniela
Published: March 2021

INTRODUÇÃO: Ocasionada, geralmente, por hábitos deletérios, a mordida aberta anterior pode persistir mesmo após a remoção do fator etiológico primario, devido ao posicionamento atípico da língua, o que torna essa má oclusão muito recidivante. CASO CLÍNICO: O presente artigo relata o caso clínico de uma paciente de oito anos e dez meses de idade que apresentava má oclusão de Classe II de Angle, mordida aberta anterior de 4,4mm, postura atípica da língua, respiração buconasal e discrepância negativa limítrofe na arcada superior. RESULTADOS: O tratamento interdisciplinar envolveu Otorrinolaringologia, Fonoaudiologia, Cirurgia e Ortodontia. O tratamento interceptativo, que alterou o padrão de hábitos e comportamentos, e o posterior tratamento ortodôntico, que envolveu exodontia de pré-molares, levaram a resultados estéticos e funcionais satisfatórios e estáveis, podendo-se observar um sutil aprofundamento da sobremordida vinte e oito meses após o término do tratamento. CONCLUSÃO: Ao fim do tratamento, o fechamento da mordida aberta foi alcançado satisfatoriamente, atendendo plenamente às expectativas da paciente e propiciando uma grande melhora estética e funcional, com estabilidade. Esse caso clínico foi apresentado ao Board Brasileiro de Ortodontia e Ortopedia Facial (BBO) como parte dos requisitos para a obtenção do título de Diplomada pelo BBO.
In Silico Prediction of Heliannuol A, B, C, D, and E Compounds on Estrogen Receptor β Agonists
Authors: Mutiah Roihatul , Firdausy Alif Firman , Indrawijaya Yen Yen Ari , Hibbbatullah Hibbatullah
Published: March 2021

Heliannuols has a benzoxepine ring that produces anticancer activity by the inhibition mechanism of phosphoinositide 3 kinases (PI3K). Heliannuols are a compound that can be found in the leaves of sunflower (Helianthus annuus L.). The purpose of this study is to predict interactions, toxicity, physicochemical, and pharmacokinetics of Heliannuol A, B, C, D, and E based in silico as candidate anticancer drugs. Estrogen receptor beta (ERβ) is a new potential therapy for glioma with an antiproliferative effect. Ligands agonist ERβ have the potential activity to inhibit the proliferation of glioma cells and the discovery of this ligand has opened new therapy through the ERβ to prolong survival in cancer patients. Prediction of physicochemical properties based on Lipinski rules and penetrate in the blood-brain barrier. Receptor validation shows that 2I0G(A) has a smaller RMSD value than 2I0G(B), receptor validation is valid if the RMSD value less than 2. The result of molecular docking shows that Heliannuols comply with Lipinski rules and have low toxicity. Heliannuols also have a similar amino acid with Erteberel, but the rerank score of Erteberel still lower than Heliannuols.Keywords: Helianthus annuus, Heliannuols, estrogen receptor β (ERβ), in silico, toxicity.
Pentagamaboronon-0-Sorbitol Induces Apoptosis through Elevation of Reactive Oxygen Species in Triple Negative Breast Cancer Cells
Authors: Ramadani Ratna Dwi , Utomo Rohmad Yudi , Hermawan Adam , Meiyanto Edy
Published: March 2021

Breast cancer is the most common type of cancer causing mortality for women due to metastasis. More than 50% of breast cancer patients are suffered lung metastases. One strategy to target the cancerous cell is Boron Neutron Captured Therapy (BNCT) which showed high affinity toward cancer cells and reported to have anti-proliferative as well as anti-metastatic activities. Pentagamaboronon-0 (PGB-0) is a curcumin analogue substance which had reported to exert anticancer activities against Her-2 expressing as well as triple negative breast cancer cells. Despite its great potency as BNCT agent candidate, this compound also exerted several anticancer properties. Complex formation of this substance with sorbitol was achieved to improve the solubility and maximize compound’s delivery to the target cells. This study aimed to investigate the ability of Pentagamaboronon-0-Sorbitol (PGB-0-So) to modulate cell cycle and induce apoptosis especially through the mechanisms of reactive oxygen species (ROS) modulation. The 3-(4,5-dimethylthiazzol-2yl)-2,5-diphenyltetrazolium (MTT) cytotoxicity assay of PGB-0-So against 4T1 breast cancer cell line were found to exert potential effect in dose-dependent manner with lethal concentration (IC50) values of 39 μM. The cytotoxicity of PGB-0-So complex was found to be increased considerably compared with that of PGB-0. Cell cycle modulation identified using propidium iodide (PI) staining showed cell accumulation in S phase following treatment with PGB-0-So. Apoptosis induction assay analyzed using flowcytometer with Annexin V and PI staining on its IC50 dose was found to induce programmed cell death (apoptosis). The sub-IC50 treatment of this compound was also improved the cellular ROS level which also took role in apoptosis induction. These findings suggest that PGB-0-So is potential as an anticancer agent.Keywords: Curcumin analogue, PGB-0-So, Anticancer, 4T1 cell line, ROS modulation.
Sustainable Economic Development and Environmental Performance of Developing and Developed Countries
Authors: TAN Chee Leong , ONG Tze San , SOH Wei Ni , RAHIM Norhuda ABDUL
Published: March 2021

At present, many economies are suffering from environmental problems that have significant effects on the climate and life of human beings, thus, the governments and institutions work to reduce the industrial negative effects on the environment.  Past studies focus on the nexus of sustainable economic development (SED) and environmental performance (EP) at the company or institution level. This study focused on the country level, and also further examined the outcome in developing and developed countries. This study examines the nexus between sustainable economic development and environmental performance of both developed and developing countries. The data of SED obtained from World Bank and Environmental Performance Index (EPI) for the period 2006-2016. This study also takes into consideration the control variable (CV) of primary school enrolment (SCH) and country population (POP), which may potentially influence the outcome of this study. For the analysis, the study employs panel regression model. The findings revealed that most of the proxies of SED have significant relationship with EPI.
Research on the Effectiveness of Black-Faced Spoonbill Bird Tourism and Conservation Strategy. A Case Study of Shifen Community at Chi-Gu District of Tainan City
Authors: HUANG Chih-Jan , YANG Yung-Nane
Published: March 2021

In this study, the concept of ecotourism serves as the framework for the investigation of black-faced spoonbill tourism and conservation strategies implemented in Shifen, a community in the Chi-Gu District of Tainan City. It featured an examination of the formulation, planning, and implementation of the conservation strategies and conducted in-depth interviews on individuals from the public sector, local residents, tourists, and nongovernment organizations. Research results identified numerous problems: latent concerns regarding black-faced spoonbills as a tourism resource, poor awareness of ecotourism, difficulties in implementing black-faced spoonbill tourism and conservation strategies, and difficulty maintaining a balance between conservation and residents’ livelihoods. The government is advised to integrate the opinions and suggestions of local residents, promote community participation, and increase job opportunities for local residents to create a win-win model for the development of community-based ecotourism.
Development of the Organizational and Economic Mechanisms of Greenhouse Industry in the Republic of Uzbekistan
Authors: DURMANOV Akmal , UMAROV Sukhrob , RAKHIMOVA Khavakhon , KHODJIMUKHAMEDOVA Shakhida , AKHMEDOV Azamat , MIRZAYEV Shakir
Published: March 2021

The goal of the article is to analyse the improvement of the organizational and economic mechanisms of the glasshouse industry in the Republic of Uzbekistan. The following methods were used in the study: comparative analysis, statistical method, estimation method, economic analysis of the results. Results of the study: the use in the greenhouses of the Republic of Uzbekistan of innovative new generation greenhouses with energy-saving technologies will reduce energy consumption, save resources and reduce the cost of vegetables. The scientific importance is the development of innovative technologies in agriculture in the Republic of Uzbekistan, and the practical importance is ensuring the efficiency of agricultural development.
Evaluation of Import Substitution Potential of Products from Secondary Raw Materials of Animal Husbandry
Authors: DENISSOVA Oxana , KONURBAYEVA Zhadyra , ZAKIMOVA Alfiya , RAKHIMBERDINOVA Madina
Published: March 2021

Animal husbandry is one of the main sectors of the country's economy, which can demonstrate significant results of import substitution shortly. In article dynamics of such relative indicators characterizing scales of industrial activity in the sphere of animal industries, as a share of the branch in the Kazakhstan economy and volumes of production of animal industries per capita of Kazakhstan is considered. For example, the average annual growth rate of this indicator is compared with countries with a high level of development of this industry. It was found out that the use of secondary raw materials of animal husbandry will promote the development of new industries and import substitution of both raw materials and finished products, which will attract innovative technologies in the agro-industrial complex. The article presents a step-by-step algorithm of research of the import-substituting potential of the industry, as well as its practical testing (by the example of the Republic of Kazakhstan). Volumes of production on branch "animal industries" are defined, connections of import dependence and the agrarian production made abroad are established.
Environmental Problems of International Legal Regulation of Transboundary Pollution
Authors: BEKEZHANOV Dauren , KOPBASSAROVA Gulnurа , ZHUNISPAYEVA Ainur , URAZYMBETOV Talgat , SEILKASSYMOVA Roza
Published: March 2021

This article is a comprehensive study on problems of legal protection of the environment from transboundary environmental pollution in the Republic of Kazakhstan. The study of international and national legislation in the field of environmental protection from transboundary environmental pollution was carried out, ways to solve legal problems related to transboundary environmental pollution were studied and proposed, theoretical concepts and practical recommendations were developed to increase the effectiveness of current legislation and the activities of state bodies in the field of environmental protection environment from transboundary environmental pollution. The theoretical significance of the study is that it will contribute to the further scientific development of conceptual problems of environmental cooperation in the field of preventing and preventing the negative effects of transboundary environmental pollution. The research itself, as well as the results obtained, will contribute to the further development of the domestic environmental law science.
Advances in Tourism Education: A Qualitative Inquiry about Emergency Remote Teaching in Higher Education
Authors: FUCHS Kevin
Published: March 2021

Online education, in its various modes, has been growing steadily worldwide due to the influence of new technologies, global adoption of the Internet, and intensifying demand for a workforce trained periodically for the ever-evolving digital economy. Well-planned online learning experiences are meaningfully different from courses offered online in response to a crisis or disaster. Higher education institutions working to maintain instruction during the COVID-19 pandemic should understand those differences when evaluating emergency remote teaching (ERT). Online distance education involves more than just uploading educational content; instead, it is a learning process that provides learners with support, responsibility, flexibility, and choice. Henceforth, the research aimed to examine undergraduate students’ (n=238) perceptions about their preferred mode of learning during COVID-19. The paper identified a significant reluctance towards emergency remote teaching from first-year students. The paper also qualitatively investigated the underlying reasons through thematic analysis. The themed findings were (1) lack of social interactions, (2) difficulties staying engaged while studying from home, and (3) technological boundaries related to the students’ Internet connections in rural areas. The paper concludes with recommendations that aim to provide institutions and educations with practical guidance on how to tackle the outlined issues.
Community Involvement and Sustainable Cave Tourism Development in Tulungagung Region
Authors: ALY M. Nilzam , HAMID Nur , SUHARNO Novianto Edi , KHOLIS Nor , AROYANDINI Elvara Norma
Published: March 2021

The model was focusing on the community involvement of tourism activities based on rural collaborative-construction with the different ways to utilize at Tenggar Cave, Tenggarrejo Village, Tulungagung region in order to ensure the sustainability ofheritage tourism development in that area. A qualitative approach through participating observation, indepth interviews, study of document and focus group discussions were obtained to reliability and validity data. Interviews were conducted to informants of the development planning agency at sub-national level, tourism government regency, Indonesian State Forest Company, the members of the local tourism community, local entrepreneur, tourist, archeology and researcher. The results indicated that local communities and other stakeholders have participated in management, conservation, tourism development of the site, solved social problems and benefit in that area such as poverty, lack of job opportunity, and corncob waste. This research suggested that collaboration model which was developed within the tourism planning must implement principles of sustainable and involve full role of the local community. Community Based Heritage Management (CBHTM) is an ideal model in the development of tourism in the Tenggar Cave area.
Racial and ethnic diversity in higher education: White privileged resistance and implications for leadership
Authors: Sawyer Lidyvez , Waite Roberta
Published: March 2021

Extrapolating history is crucial to mitigating the current underpinnings of racial and ethnic inequities in higher education; however, to establish sustainable change, one must consider its fundamental origin. The inception of 15th-century white settler colonialism is at the epicenter of modern-day racial discrimination and the normalcy of oppressive practices in the United States' education system (US) of America. To understand white settler colonialism and its denigrating manifestations is to understand the dynamics between those in power and those who are subjugated. America's white settler colonialism's horrific ideology is insidiously depicted through torture, persecution, brutality, plunder, and pillage (Traore, 2004). This ideology is the foundation that breeds our society's racial and ethnic hierarchy, including in higher education. Racial discrimination in higher education creates a partisan, culturally divided learning environment, frequently normalized in academic leadership. The purpose of this paper is three-fold: (a) to examine normalized whiteness in higher education, (b) to examine how mere talk about diversity and inclusion inhibits disruption in power to transforming modern-day consciousness of inequities, discrimination, and racism, and (c)  discuss action steps to promote leadership among black and brown raced individuals in higher education.
“It’s a sea-change”: Understanding the role the racial and socio-political climate play on the role-shift of the American college presidency
Authors: Tevis Tenisha
Published: March 2021

This inquiry is part of a larger study focused on whether white male presidents in higher education can respond to racism. In the initial study, the author concluded that while presidents were responsive, their responses were not void of privilege, and highlighted the need to further address white Fragility amongst this group. In an effort to advance our understanding of the American college presidency, particularly how the racial and socio-political climate has shaped their leadership, in the current study, the author analyzed data using the perspective offered by the presidents – higher education is in a sea-change, which was also a finding, as well as specific facets of Astin and Astin’ (2000) and Buller’s (2015) respective frames of change. The analysis yielded the importance of naming that higher education is in a sea-change, grappled with the reality of power within the presidency, and articulated the value of being willing over being ready to incite change. In light of these findings, these leaders recognized that not only is higher education due for a change, but so is the postsecondary presidency. Such an understanding expands both the organizational leadership and diversity in higher education literature, respectively.