bluuebunny/crossref_metadata_2025 huggingface dataset:
Association Between Pittsburgh Sleep Quality Index and Depressive Symptoms in Chinese Resident Physicians
Authors: Chang Qing , Xia Yang , Bai Song , Zhang Xi , Liu Yashu , Yao Da , Xu Xinrui , Zhao Yuhong
Published: June 2021

Background: Previous studies have suggested that sleep quality is associated with depressive symptoms. However, associations between overall sleep quality and depressive symptoms in Chinese resident physicians remain unclear. Therefore, we aimed to determine whether overall sleep quality is associated with depressive symptoms in Chinese resident physicians.

Methods: This cross-sectional study included 1,230 resident physicians. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression analysis was applied to estimate the associations between the PSQI and PHQ-9.

Results: Among all participants, the prevalence of mild (PHQ-9 ≥ 5) and moderate or severe (PHQ-9 ≥ 10) depressive symptoms were 48.28 and 12.93%, respectively. PSQI score was positively associated with PHQ-9 score before and after adjustments of socio-demographic, behavioral, and psychologic confounding factors (all P < 0.0001). After adjustments, the regression coefficients (standard error) between PSQI scores and PHQ-9 scores were 0.95 (0.04), 0.88 (0.09), and 0.96 (0.05) in all participants, men, and women, respectively. Compared to physicians with good sleep quality (PSQI scores ≤ 5), the adjusted odds ratios (ORs) [95% confidence intervals (CIs)] for mild (PHQ-9 ≥ 5) and moderate or severe (PHQ-9 ≥ 10) depressive symptoms in physicians with poor sleep quality were 7.15 (5.44, 9.46) and 6.17 (4.03, 9.71) in all participants, respectively.

Conclusions: Our findings suggest that poor sleep quality was associated with a higher prevalence of depressive symptoms in Chinese resident physicians.
Reaching the Unreached: Bridging Islam and Science to Treat the Mental Wounds of War
Authors: Zoellner Lori A. , Bentley Jacob A. , Feeny Norah C. , Klein Alexandra B. , Dolezal Michael L. , Angula Dega A. , Egeh Momin H.
Published: June 2021

Radical new paradigms are needed to equip non-professionals and leverage community faith-based infrastructure to address the individual and communal wounds of war- and conflict-related trauma. Muslims in war-torn regions like Somalia experience high rates of trauma and posttraumatic stress; yet, lack of providers, potential stigma, and lack of integration with one's faith are substantial barriers to care. In this pre-post feasibility clinical trial (NCT03761732), mosque leaders implemented a brief, group- and mosque-based intervention, Islamic Trauma Healing, targeting trauma-related psychopathology and community reconciliation for trauma survivors (N = 26) in Somaliland, Somalia. Leaders were trained in a brief 2-day training, with supervision provided remotely via WhatsApp. This six-session intervention combines empirically-supported trauma-focused psychotherapy and Islamic principles, focusing on wisdom from the lives of the Prophets and turning to Allah in dua about trauma. There were large, clinically meaningful effects for PTSD (g = 1.91), depression (g = 2.00), somatic symptoms (g = 2.73), and well-being (g = 1.77). Qualitative data from group members highlighted how well the program was aligned with their Islamic faith, built community, and need to expand the program. These results highlight the feasibility of this non-expert, easily up-scalable mental health approach in war-torn Muslim regions and refugee communities. This program has the potential to provide a low-cost, self-sustaining, Islam-based intervention addressing the psychological wounds of war consistent with the IOM's call to develop novel approaches to address unmet clinical needs.

ClinicalTrials.govIdentifier: NCT03761732.
Relationship of Brain Glutamate Response to D-Cycloserine and Lurasidone to Antidepressant Response in Bipolar Depression: A Pilot Study
Authors: Dong Zhengchao , Grunebaum Michael F. , Lan Martin J. , Wagner Vashti , Choo Tse-Hwei , Milak Matthew S. , Sobeih Tarek , Mann J. John , Kantrowitz Joshua T.
Published: June 2021

N-methyl-D-aspartate glutamate-receptor (NMDAR) antagonists such as ketamine have demonstrated efficacy in both major depressive disorder (MDD) and bipolar disorder depression (BP-D). We have previously reported that reduction in Glx (glutamate + glutamine) in the ventromedial prefrontal cortex/anterior cingulate cortex (vmPFC/ACC), measured by proton magnetic resonance spectroscopy (1H MRS) at 3T during a ketamine infusion, mediates the relationship of ketamine dose and blood level to improvement in depression. In the present study, we assessed the impact of D-cycloserine (DCS), an oral NMDAR antagonist combined with lurasidone in BP-D on both glutamate and Glx. Subjects with DSM-V BP-D-I/II and a Montgomery-Asberg Depression Rating Scale (MADRS) score>17, underwent up to three 1H MRS scans. During Scan 1, subjects were randomized to receive double-blind lurasidone 66 mg or placebo. During Scan 2, all subjects received single-blind DCS 950 mg + lurasidone 66 mg, followed by 4 weeks of open label phase of DCS+lurasidone and an optional Scan 3. Five subjects received lurasidone alone and three subjects received placebo for Scan 1. Six subjects received DCS+lurasidone during Scan 2. There was no significant baseline or between treatment-group differences in acute depression improvement or glutamate response. In Scan 2, after a dose of DCS+lurasidone, peak change in glutamate correlated negatively with improvement from baseline MADRS (r = −0.83, p = 0.04). There were no unexpected adverse events. These preliminary pilot results require replication but provide further support for a link between antidepressant effect and a decrease in glutamate by the NMDAR antagonist class of antidepressants.
Teachers' Knowledge and Stigmatizing Attitudes Associated With Obsessive-Compulsive Disorder: Effectiveness of a Brief Educational Intervention
Authors: Chaves Antonio , Arnáez Sandra , Roncero María , García-Soriano Gemma
Published: June 2021

Because children and adolescents are vulnerable to developing obsessive-compulsive disorder (OCD), classroom teachers play an important role in the early identification and intervention in students with OCD. The present study aims to explore the recognition of OCD, general knowledge about this disorder, implications in the classroom, and stigmatizing attitudes among teachers, as well as the effectiveness of a brief educational intervention about OCD. Participants (n = 95; mean age = 43. 29 years old; 64.3% female) were primary and secondary school teachers who were randomly assigned to an experimental group or a control group. All of them completed a set of self-report questionnaires, read an educational fact sheet (either about OCD in the experimental group or about a healthy diet in the control group), and again completed the questionnaires. Results show that prior to the intervention, most of the teachers identified the contamination and order OCD symptoms described in a vignette as specific to OCD (82.1%) and would recommend talking about the problem (98.9%) and seeking help (94.7%). However, only a few (36.8%) knew about the most effective OCD treatments or identified compulsions as a main OCD symptom (33%). Moreover, only about half of the teachers correctly identified OCD's possible interference in classroom routines, such as delays to achieve perfection or concentration problems, and strategies for dealing with OCD, such as continuing with the class rhythm. Stigma levels were from low to moderate. After the brief educational intervention, participants in the experimental group increased their knowledge about OCD, improved their strategies for managing a student with OCD symptoms, and had fewer stigmatizing attitudes associated with pity (p < 0.05). These changes were not observed in the control group. We can conclude that this brief and easy-to-administer intervention is an effective educational intervention to significantly improve teachers' knowledge and attitudes, at least in the short-term. These results are especially relevant because OCD is associated with high interference and long delays in seeking treatment, and teachers have a unique opportunity to help with prevention, early identification, and recommending an adequate intervention for OCD.
Symptoms of Depression and Anxiety During the Early Phase of the COVID-19 Pandemic in Sweden
Authors: Rondung Elisabet , Leiler Anna , Meurling Jennifer , Bjärtå Anna
Published: June 2021

In this cross-sectional study we aimed to assess symptoms of depression and anxiety at an early stage of the COVID-19 pandemic, and to explore factors predictive of these mental health outcomes. A sample of 1,503 participants, recruited from the general Swedish population, completed an online survey distributed through social media. In this sample, 22.2% reported clinically significant levels of depressive symptoms (PHQ-9 ≥ 10) and 10.9% indicated possible major depression using the PHQ-9 algorithm. Moreover, 28.3% reported clinically significant levels of anxiety (GAD-7 ≥ 8) and 9.7% severe anxiety and possible GAD (GAD-7 ≥ 15). Multiple linear regression analyses identified some common predictors for both outcomes. Age, having a stable income, and sufficient social stimulation, sleep, and recovery showed negative associations, whereas worry about the economy and overall burden showed positive associations. These results suggest an impact on mental health already at an early stage of the COVID-19 pandemic.
Photometric Redshifts With Machine Learning, Lights and Shadows on a Complex Data Science Use Case
Authors: Brescia Massimo , Cavuoti Stefano , Razim Oleksandra , Amaro Valeria , Riccio Giuseppe , Longo Giuseppe
Published: June 2021

The importance of the current role of data-driven science is constantly increasing within Astrophysics, due to the huge amount of multi-wavelength data collected every day, characterized by complex and high-volume information requiring efficient and, as much as possible, automated exploration tools. Furthermore, to accomplish main and legacy science objectives of future or incoming large and deep survey projects, such as James Webb Space Telescope (JWST), James Webb Space Telescope (LSST), and Euclid, a crucial role is played by an accurate estimation of photometric redshifts, whose knowledge would permit the detection and analysis of extended and peculiar sources by disentangling low-z from high-z sources and would contribute to solve the modern cosmological discrepancies. The recent photometric redshift data challenges, organized within several survey projects, like LSST and Euclid, pushed the exploitation of the observed multi-wavelength and multi-dimensional data orad hocsimulated data to improve and optimize the photometric redshifts prediction and statistical characterization based on both Spectral Energy Distribution (SED) template fitting and machine learning methodologies. They also provided a new impetus in the investigation of hybrid and deep learning techniques, aimed at conjugating the positive peculiarities of different methodologies, thus optimizing the estimation accuracy and maximizing the photometric range coverage, which are particularly important in the high-z regime, where the spectroscopic ground truth is poorly available. In such a context, we summarize what was learned and proposed in more than a decade of research.
Reasons for Exclusion of Apparently Healthy Mature Adult and Senior Dogs From a Clinical Trial
Authors: Gibbs Nicole H. , Michalski Hannah , Promislow Daniel E. L. , Kaeberlein Matt , Creevy Kate E.
Published: June 2021

Background:Interventional clinical trials intended to maintain health in aging dogs are unusual and require particular attention to exclusion criteria.

Objectives:To describe reasons for exclusion when a mature adult and senior canine population with normal health status was sought.

Animals:Fifty six companion dogs nominated for a randomized controlled trial (RCT).

Procedures:Exclusions occurred within Stage 1 (S1): owner-provided survey information; Stage 2 (S2): medical records review; and Stage 3 (S3): screening examination and within Owner, Dog, or Other factor categories.

Results:Of 56 nominated dogs, 39 were excluded at S1 (n= 19), S2 (n= 5), and S3 (n= 15), respectively. Dogs were excluded for Owner (n= 4), Dog (n= 27), Other (n= 6), and concurrent (Owner + Dog;n= 2) factors. The most common exclusion period was S1 (n= 19), with weight outside the target range being the most common exclusion factor in that stage (n= 10). Heart murmurs were the second most common exclusion factor (S1:n= 1; S3:n= 5); suspected or confirmed systemic illness was third most common (S1:n= 2; S2:n= 3; S3:n= 2). Among dogs who passed S1 and S2 screening (n= 32), 15 dogs (48%) were excluded at S3, for heart murmur > grade II/VI (n= 5), cardiac arrhythmias (n= 2), and clinicopathologic abnormalities (n= 2).

Conclusions and Clinical Relevance:Dogs nominated for a clinical trial for healthy mature adult and senior dogs were excluded for size, previous diagnoses, and newly discovered cardiac abnormalities. For future interventions in mature adult and senior dogs of normal health status, it is important to define expected age-related abnormalities to ensure that meaningful exclusion criteria are used.
Epidemiology of Bovine Pestiviruses Circulating in Italy
Authors: Luzzago Camilla , Decaro Nicola
Published: June 2021

Pestiviruses are widespread and economically important pathogens of cattle and other animals. Pestivirus A (formerly known as Bovine viral diarrhea virus 1, BVDV-1), Pestivirus B (Bovine viral diarrhea virus 2, BVDV-2), and Pestivirus H (HoBi-like pestivirus, HoBiPeV) species are infecting primarily cattle. Like other RNA viruses, pestiviruses are characterized by a high degree of genetic variability. This high rate of variability is revealed by the existence of a number of viral subgenotypes within each species. In cattle, the highest number of pestivirus subgenotypes has been documented in European countries, particularly in Italy. The aim of this review is to report an up-to-date overview about the genetic diversity of pestiviruses in Italian cattle herds. All three bovine pestiviruses species have been identified in cattle population with variable frequency and geographical distribution. The genetic diversity of Italian pestiviral strains may have diagnostic and immunological implications, affecting the performance of diagnostic tools and the full cross-protection elicited by commercially available vaccines. Implementation and strengthening of coordinated approaches for bovine pestivirus control in Italy are recommended. Therefore, it would be extremely important to increase control and restriction measures to the trade of cattle and biological products of bovine origin, including those containing fetal bovine serum.
The Effect of Vortex Generators on Shock-Induced Boundary Layer Separation in a Transonic Convex-Corner Flow
Authors: Chung Kung-Ming , Su Kao-Chun , Chang Keh-Chin
Published: June 2021

Deflected control surfaces can be used as variable camber control in different flight conditions, and a convex corner resembles a simplified configuration for the upper surface. This experimental study determines the presence of passive vortex generators, VGs (counter-rotating vane type), on shock-induced boundary layer separation for transonic convex-corner flow. The mean surface pressure distributions in the presence of VGs for h/δ = 0.2 and 0.5 are similar to those for no flow control. If h/δ = 1.0 and 1.5, there is an increase in the amplitude of the mean surface pressure upstream of the corner’s apex, which corresponds to greater device drag and less downstream expansion. There is a decrease in peak pressure fluctuations as the value of h/δ increases, because there is a decrease in separation length and the frequency of shock oscillation. The effectiveness of VGs also depends on the freestream Mach number. For M = 0.89, there is an extension in the low-pressure region downstream of a convex corner, because there is greater convection and induced streamwise vorticity. VGs with h/δ ≤ 0.5 are preferred if deflected control surfaces are used to produce lift.
The Digitalization of the European Agri-Food Cooperative Sector. Determining Factors to Embrace Information and Communication Technologies
Authors: Jorge-Vázquez Javier , Chivite-Cebolla Mª Peana , Salinas-Ramos Francisco
Published: June 2021

The digitization of the agri-food sector is a strategic priority in the political agenda of European institutions. The opportunity to improve the competitiveness and efficiency of the sector offered by new technologies comes together with its potential to face new economic and environmental challenges. This research aims to analyze the level of digitalization of the European agri-food cooperative sector from the construction of a composite synthetic index. Such an index is to be based on a diverse set of variables related to electronic commerce and the services offered through the internet. It also evaluates how European cooperatives influence the degree of technological adoption depending on their size or the wealth of the country where they carry out their activity. The empirical analytical method is thus used, through the analysis of frequencies and correlations. The results obtained reveal the existence of a suboptimal and heterogeneous degree of digitization of European agri-food cooperatives, clearly conditioned by their size and the wealth of the country where they operate. In this situation, it is recommended to promote public policies that guarantee high-performance digital connectivity, an improvement in training in digital skills and the promotion of cooperative integration processes.
FTIR Screening to Elucidate Compositional Differences in Maize Recombinant Inbred Lines with Contrasting Saccharification Efficiency Yields
Authors: López-Malvar Ana , Santiago Rogelio , Malvar Rosa Ana , Martín Daniel , Pereira dos Santos Inês , Batista de Carvalho Luís A. E. , Faas Laura , Gómez Leonardo D. , da Costa Ricardo M. F.
Published: June 2021

With a high potential to generate biomass, maize stover arises as an outstanding feedstock for biofuel production. Maize stover presents the added advantage of being a multiple exploitation of the crop as a source of food, feed, and energy. In this study, contrasting groups of recombinant inbred lines (RILs) from a maize multiparent advanced generation intercross (MAGIC) population that showed variability for saccharification efficiency were screened by FTIR-ATR spectroscopy to explore compositional differences between high and low saccharification yielders. High and low saccharification efficiency groups differed in cell wall compositional features: high saccharification RILs displayed higher proportions of S subunits, aromatic compounds, and hemicellulose as opposed to low saccharification efficiency groups in which FTIR predicted higher proportions of lignin, more precisely lignin being richer in subunits G, and greater proportions of crystalline cellulose and acetyl methyl esters. The application of FTIR-ATR spectroscopy in this material allowed us to obtain a rapid and broad vision of cell wall compositional features in contrasting groups of saccharification efficiency. These results helped us to deepen our knowledge into the relationship between cell wall composition and biorefining potential; they also allowed us to establish new targets for future research regarding lignocellulosic bioconversion.
Postharvest Storage Techniques and Quality Evaluation of Fruits and Vegetables for Reducing Food Loss
Authors: Ziv Carmit , Fallik Elazar
Published: June 2021

Fresh fruits and vegetables have always made an important contribution to the human diet [...]
The Effects of Vehicle Type, Transport Duration and Pre-Transport Feeding on the Welfare of Sheep Transported in Low Temperatures
Authors: Carnovale Francesca , Xiao Jin , Shi Binlin , Kaart Tanel , Arney David , Phillips Clive J. C.
Published: June 2021

Low temperatures can provide a risk to the welfare of sheep during transport because of increased ventilation chilling the sheep, and we examined the importance of three factors—covering the vehicle, duration of transport, and feeding prior to transport—on the welfare of sixty transported 4-month-old Dorper × Mongolian female sheep in a cold climate. Sheep in a covered vehicle had greater increases in head and ear temperatures than those in an open vehicle. Sheep transported for 2 h increased their leg temperatures, whereas those transported for 1 h had reduced leg temperatures. Increases in non-esterified fatty acids (NEFA) and lactate dehydrogenase (LDH) in the blood samples during the long transport suggested that sheep had more muscular and metabolic activity, compromising their well-being. Feeding prior to transport did not affect body temperatures, but those not fed prior to transport had reduced alanine transferase, HSP and cortisol in their blood, whereas those that were fed had reduced NEFAs, LDH and creatine kinase. Prior feeding had no effect on the sheep temperature indices over a two-hour transport period. Thus, the sheep most at risk of the adverse effects of cold temperatures were those transported in open vehicles, those transported for a longer time, and those not fed before transport.
Diffusible Compounds Produced by Hanseniaspora osmophila and Gluconobacter cerinus Help to Control the Causal Agents of Gray Rot and Summer Bunch Rot of Table Grapes
Authors: Olivera Matías , Delgado Ninoska , Cádiz Fabiola , Riquelme Natalia , Montenegro Iván , Seeger Michael , Bravo Guillermo , Barros-Parada Wilson , Pedreschi Romina , Besoain Ximena
Published: June 2021

Gray and summer bunch rot are important diseases of table grapes due to the high economic and environmental cost of their control with synthetic fungicides. The ability to produce antifungal compounds against the causal agents Botrytis, Aspergillus, Penicillium, and Rhizopus of two microorganisms isolated from table grapes and identified as Hanseniaspora osmophila and Gluconobacter cerinus was evaluated. In dual cultures, both biocontrol agents (together and separately) inhibited in vitro mycelial growth of these pathogens. To identify the compounds responsible for the inhibitory effect, extractions were carried out with organic solvents from biocontrol agents separately. Through dual cultures with pathogens and pure extracts, only the hexane extract from H. osmophila showed an inhibitory effect against Botrytis cinerea. To further identify these compounds, the direct bioautography technique was used. This technique made it possible to determine the band displaying antifungal activity at Rf = 0.05–0.2. The compounds present in this band were identified by GC-MS and compared to the NIST library. The most abundant compounds, not previously reported, corresponded to alkanes, ketones, alcohols, and terpenoids. H. osmophila and G. cerinus have the potential to control the causal agents of gray and summer bunch rot of table grapes.
Early Treatment Outcomes for Bloodstream Infections Caused by Potential AmpC Beta-Lactamase-Producing Enterobacterales with Focus on Piperacillin/Tazobactam: A Retrospective Cohort Study
Authors: Herrmann Lena , Kimmig Aurelia , Rödel Jürgen , Hagel Stefan , Rose Norman , Pletz Mathias W. , Bahrs Christina
Published: June 2021

The Gram-negative bacilli Serratia spp., Providencia spp., Morganella morganii, Citrobacter freundii complex, Enterobacter spp. and Klebsiella aerogenes are common Enterobacterales that may harbor inducible chromosomal AmpC beta-lactamase genes. The purpose of the present study was to evaluate treatment outcomes and identify predictors of early treatment response in patients with bloodstream infection caused by potential AmpC beta-lactamase-producing Enterobacterales (SPICE-BSI). This cohort study included adult patients with SPICE-BSI hospitalized between 01/2011 and 02/2019. The primary outcome was early treatment response 72 h after the start of active treatment, defined as survival, hemodynamic stability, improved or stable SOFA score, resolution of fever and leukocytosis and microbiologic resolution. Among 295 included patients, the most common focus was the lower respiratory tract (27.8%), and Enterobacter spp. (n = 155) was the main pathogen. The early treatment response rate was significantly lower (p = 0.006) in the piperacillin/tazobactam group (17/81 patients, 21.0%) than in the carbapenem group (40/82 patients, 48.8%). Independent negative predictors of early treatment response (p < 0.02) included initial SOFA score, liver comorbidity and empiric piperacillin/tazobactam treatment. In vitro piperacillin/tazobactam resistance was detected in three patients with relapsed Enterobacter-BSI and initial treatment with piperacillin/tazobactam. In conclusion, our findings show that piperacillin/tazobactam might be associated with early treatment failure in patients with SPICE-BSI.
Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
Authors: D’Amico Ramona , Trovato Salinaro Angela , Fusco Roberta , Cordaro Marika , Impellizzeri Daniela , Scuto Maria , Ontario Maria Laura , Lo Dico Gianluigi , Cuzzocrea Salvatore , Di Paola Rosanna , Siracusa Rosalba , Calabrese Vittorio
Published: June 2021

Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments. TBI has been shown to be a risk factor for neurodegeneration which can lead to Parkinson’s disease (PD) for example. In this study, we wanted to explore the development of PD-related pathology in the context of an experimental model of TBI and the potential ability of Coriolus versicolor and Hericium erinaceus to prevent neurodegenerative processes. Traumatic brain injury was induced in mice by controlled cortical impact. Behavioral tests were performed at various times: the animals were sacrificed 30 days after the impact and the brain was processed for Western blot and immunohistochemical analyzes. After the head injury, a significant decrease in the expression of tyrosine hydroxylase and the dopamine transporter in the substantia nigra was observed, as well as significant behavioral alterations that were instead restored following daily oral treatment with Hericium erinaceus and Coriolus versicolor. Furthermore, a strong increase in neuroinflammation and oxidative stress emerged in the vehicle groups. Treatment with Hericium erinaceus and Coriolus versicolor was able to prevent both the neuroinflammatory and oxidative processes typical of PD. This study suggests that PD-related molecular events may be triggered on TBI and that nutritional fungi such as Hericium erinaceus and Coriolus versicolor may be important in redox stress response mechanisms and neuroprotection, preventing the progression of neurodegenerative diseases such as PD.
Curcugreen Treatment Prevented Splenomegaly and Other Peripheral Organ Abnormalities in 3xTg and 5xFAD Mouse Models of Alzheimer’s Disease
Authors: Manna Jayeeta , Dunbar Gary L. , Maiti Panchanan
Published: June 2021

Metabolic dysfunction and immune disorders are common in Alzheimer’s disease (AD). The mechanistic details of these epiphenomena in AD are unclear. Here, we have investigated whether a highly bioavailable curcuminoid formulation, curcugreen (CGR), can prevent abnormalities in peripheral organs of two mouse models of AD. Eighteen- and 24-month-old male and female 3xTg and 5xFAD mice were treated with CGR (100 mg/kg) for 2 months, orally. Cytoarchitectural changes of spleen, liver, kidney and lungs were studied by H&E stain. Apoptotic death was confirmed by TUNEL staining. Amyloid deposition, pTau levels, proinflammatory, anti-inflammatory and cell death/survival markers were studied by Western blots. Curcugreen reduced the observed splenomegaly (3xTg) and degeneration of spleen, granulomatous inflammation in the kidney, hepatic sinusoidal disorganization, hepatocellular hypertrophy, inflammation of the central hepatic vein, infiltration and swelling of lung tissues, and apoptotic death in all these areas in both 3xTg and 5xFAD mice. Similarly, CGR decreased amyloid deposition, pTau, proinflammatory markers, cell loss and decrements in anti-inflammatory markers in both 3xTg and 5xFAD mice. Peripheral organ abnormalities and inflammatory responses in AD were ameliorated by curcuminoid treatment.
Geomorphological Geometries and High-Resolution Seismic Sequence Stratigraphy of Malay Basin’s Fluvial Succession
Authors: Al-Masgari Abd Al-Salam , Elsaadany Mohamed , Siddiqui Numair A. , Latiff Abdul Halim Abdul , Bakar Azli Abu , Elkurdy Sami , Hermana Maman , Babikir Ismailalwali , Imran Qazi Sohail , Adeleke Teslim
Published: June 2021

This study identified the Pleistocene depositional succession of the group (A) (marine, estuarine, and fluvial depositional systems) of the Melor and Inas fields in the central Malay Basin from the seafloor to approximately −507 ms (522 m). During the last few years, hydrocarbon exploration in Malay Basin has moved to focus on stratigraphic traps, specifically those that existed with channel sands. These traps motivate carrying out this research to image and locate these kinds of traps. It can be difficult to determine if closely spaced-out channels and channel belts exist within several seismic sequences in map-view with proper seismic sequence geomorphic elements and stratigraphic surfaces seismic cross lines, or probably reinforce the auto-cyclic aggregational stacking of the avulsing rivers precisely. This analysis overcomes this challenge by combining well-log with three-dimensional (3D) seismic data to resolve the deposition stratigraphic discontinuities’ considerable resolution. Three-dimensional (3D) seismic volume and high-resolution two-dimensional (2D) seismic sections with several wells were utilized. A high-resolution seismic sequence stratigraphy framework of three main seismic sequences (3rd order), four Parasequences sets (4th order), and seven Parasequences (5th order) have been established. The time slice images at consecutive two-way times display single meandering channels ranging in width from 170 to 900 m. Moreover, other geomorphological elements have been perfectly imaged, elements such as interfluves, incised valleys, chute cutoff, point bars, and extinction surfaces, providing proof of rapid growth and transformation of deposits. The high-resolution 2D sections with Cosine of Phase seismic attributes have facilitated identifying the reflection terminations against the stratigraphic amplitude. Several continuous and discontinuous channels, fluvial point bars, and marine sediments through the sequence stratigraphic framework have been addressed. The whole series reveals that almost all fluvial systems lay in the valleys at each depositional sequence’s bottom bars. The degradational stacking patterns are characterized by the fluvial channels with no evidence of fluvial aggradation. Moreover, the aggradation stage is restricted to marine sedimentation incursions. The 3D description of these deposits permits distinguishing seismic facies of the abandoned mud channel and the sand point bar deposits. The continuous meandering channel, which is filled by muddy deposits, may function as horizontal muddy barriers or baffles that might isolate the reservoir body into separate storage containers. The 3rd, 4th, and 5th orders of the seismic sequences were established for the studied succession. The essential geomorphological elements have been imaged utilizing several seismic attributes.
Impact of Using Chevrons Nozzle on the Acoustics and Performances of a Micro Turbojet Engine
Authors: Cican Grigore , Deaconu Marius , Crunteanu Daniel-Eugeniu
Published: June 2021

This paper presents a study regarding the noise reduction of the turbojet engine, in particular the jet noise of a micro turbojet engine. The results of the measurement campaign are presented followed by a performances analysis which is based on the measured data by the test bench. Within the tests, beside the baseline nozzle other two nozzles with chevrons were tested and evaluated. First type of nozzle is foreseen with eight triangular chevrons, the length of the chevrons being L = 10 percentages from the equivalent diameter and an immersion angle of I = 0 deg. For the second nozzle the length and the immersion angle were maintained, only the chevrons number were increased at 16. The micro turbojet engine has been tested at four different regimes of speed. The engine performances were monitored by measuring the fuel flow, the temperature in front of the turbine, the intake air flow, the compression ratio, the propulsion force and the temperature before the compressor. In addition, during the testing, the vibrations were measured on axial and radial direction which indicate a normal functioning of the engine during the chevron nozzles testing. Regarding the noise, it was concluded that at low regimes the noise doesn’t presents any reduction when using the chevron nozzles, while at high regimes an overall noise reduction of 2–3 dB(A) was achieved. Regarding the engine performances, a decrease in the temperature in front of the turbine, compression ratio and the intake air and fuel flow was achieved and also a drop of few percent of the propulsion force.
Measurement of Tooth Wear by Means of Digital Impressions: An In-Vitro Evaluation of Three Intraoral Scanning Systems
Authors: Kühne Christina , Lohbauer Ulrich , Raith Stefan , Reich Sven
Published: June 2021

This in-vitro study aimed to investigate whether intraoral scanners (IOS) are suitable for wear measurement compared to optical profilometry (WLP). A zirconia cast representing the teeth (24–28) was fabricated. It was digitized six times using three different intraoral scanners, Cerec Omnicam AC (OC), Trios 3 (Tr3), and True Definition (TD). The scans were conducted at baseline (t0) and at three different stages of simulated wear (t1–t3), each at one wear-facet on FDI 26 and FDI 27. WLP was used as a reference method. Within each acquisition system, the maximum wear at each facet was analyzed by superimposing the STL data of t0 with t1–t3. A power analysis was performed (G*Power), and the Wilcoxon-signed-rank-test was used to evaluate whether there were statistically significant differences between the groups (Bonferroni corrected) (α = 0.05). At wear-facet FDI 27, differences from +4% t1 TD up to +19% t2 OC, corresponding to a metric value of 8 µm and 45 µm, were measured. At FDI 26 deviations between −2% t1 Tr3, and +10% OC and Tr3, were observed. Considering some limitations, the IOS are a promising alternative to wear measurement based on WLP due to its simple application to capture surface changes in a reasonable and quick way.
Frictional Behavior of Cochlear Electrode Array Is Dictated by Insertion Speed and Impacts Insertion Force
Authors: Dohr Dana , Fiedler Nicklas , Schmidt Wolfram , Grabow Niels , Mlynski Robert , Schraven Sebastian P.
Published: June 2021

Background: During cochlear implantation, the electrode array has significant friction with the sensitive endocochlear lining and causes mutual mechanical trauma while the array is being inserted. Both, the impact of insertion speed on electrode friction and the relationship of electrode insertion force and friction have not been adequately investigated to date. Methods: In this study, friction coefficients between a CI electrode array (31.5 mm) and a tissue simulating the endocochlear lining have been acquired, depending on different insertion speeds (0.1, 0.5, 1.0, 1.5, and 2.0 mm/s). Additionally, the electrode insertion forces during the placing into a scala tympani model were recorded and correlated with the friction coefficient. Results: It was shown that the friction coefficient reached the lowest value at an insertion speed of 0.1 mm/s (0.24 ± 0.13), a maximum occurred at 1.5 mm/s (0.59 ± 0.12), and dropped again at 2 mm/s (0.45 ± 0.11). Similar patterns were observed for the insertion forces. Consequently, a high correlation coefficient (0.9) was obtained between the insertion forces and friction coefficients. Conclusion: The present study reveals a non-linear increase in electrode array friction, when insertion speed raises and reports a high correlation between friction coefficient and electrode insertion force. This dependence is a relevant future parameter to evaluate and reduce cochlear implant insertion trauma. Significance statement: Here, we demonstrated a dependence between cochlear electrode insertion speed and its friction behavior and a high correlation to insertion force. Our study provides valuable information for the evaluation and prevention of cochlear implant insertion trauma and supports the optimization of cochlear electrode arrays regarding friction characteristics.
Investigations about Al and Cu-Based Planar Spiral Inductors on Sapphire for GaN-Based RF Applications
Authors: Lin Chen , Zhan Teng , Wang Junxi , Li Jinmin , Liu Zhiqiang , Yi Xiaoyan
Published: June 2021

Conventionally, Cu is preferred over Al to fabricate integrated inductors with higher quality factors on either silicon or sapphire substrates, profiting from its lower resistivity. However, after investigating and comparing these two kinds of metal multilayers in terms of fabrication process, electrical conductivity, in-depth profile analysis and performance of actual inductors, the Al-based metal multilayer exhibits competitive ability in fabricating thin-film inductors on sapphire compared to Cu-based multilayers. This is attributed to the degradation in electrical conductivity out of oxidation of Cu-based metal sublayers or forming alloys between them. Furthermore, in order to avoid complicated de-embedding procedures in the characterization of the on-chip inductors, a six-element equivalent physical model, which takes the parasitic effect of radio-frequency (RF) test structures into account, is proposed and validated by matching well with embedded measurement results.
Recovery of Zinc and Copper from Mine Tailings by Acid Leaching Solutions Combined with Carbon-Based Materials
Authors: Álvarez María Luisa , Méndez Ana , Rodríguez-Pacheco Roberto , Paz-Ferreiro Jorge , Gascó Gabriel
Published: June 2021

Mine tailing storage represents an important environmental issue. The generation and dispersal of dust from mine tailings can contaminate air and surrounding soils. In addition, metals and soluble salts present in these wastes could pollute groundwater and surface water. The recovery of metals from mine tailings can contribute to minimize the environmental risk and to achieve a circular economy model. The main objective of the present work is to study the use of two carbon-based materials, a commercial activated carbon (AC) and a commercial charcoal (VC) in the leaching of zinc and copper from low-grade tailing waste. Experimental results obtained show that it is possible to achieve the recovery of more than 87 wt% of Zn after 6 h of leaching with different sulfuric acid solutions. The addition of carbon-based materials increases the extraction of Zn at high sulfuric acid concentrations (1 M) from 89% to 99%. The addition of VC significantly increases the extraction of Cu in leaching solution with high sulfuric acid concentration (1 M), from 41 to 61%. Future research will be necessary to optimize the properties of carbon-based materials and their recovery after leaching experiments in order to assess their potential for industrial application.
Chemical Profiling, Antioxidant, and Antimicrobial Activity against Drug-Resistant Microbes of Essential Oil from Withania frutescens L.
Authors: EL Moussaoui Abdelfattah , Bourhia Mohammed , Jawhari Fatima Zahra , Salamatullah Ahmad Mohammad , Ullah Riaz , Bari Ahmed , Majid Mahmood Hafiz , Sohaib Muhammad , Serhii Bohza , Rozhenko Alexander , Aboul-Soud Mourad A. M. , Ezzeldin Essam , Mostafa Gamal A. E. , Bousta Dalila , Bari Amina
Published: June 2021

This work was conducted to study the chemical composition, antioxidant, antibacterial, and antifungal activities of essential oil and hydrolat from Withania frutescens. The essential oil was extracted by hydrodistillation. The chemical characterization was performed using gas chromatography-mass spectrometry (GC/MS). The antioxidant activity was studied using four different assays (DPPH, TAC, FRAP, and β-carotene bleaching). The antibacterial activity test was carried out on multidrug-resistant bacteria including Gram-negative and Gram-positive strains. Antifungal activity was tested on Candida albicans and Saccharomyces cerevisiae. The yield of essential oil (EO) obtained by hydrodistillation of W. frutescens was 0.31% majorly composed of camphor, α-thujone, carvacrol, and thymol. Regarding the antioxidant activities, the concentration of the sample required to inhibit 50% of radicals (IC50) of EO and hydrolat were 14.031 ± 0.012 and 232.081 ± 3.047 µg/mL (DPPH), 4.618 ± 0.045 and 8.997 ± 0.147 µg/mL (FRAP), 0.091 ± 0.007 and 0.131 ± 0.004 mg AAE/mg (TAC), 74.141 ± 1.040% and 40.850 ± 0.083% (β-carotene), respectively. Concerning the antibacterial activity of essential oil and hydrolat, the minimum inhibitory concentration (MIC) values found were 0.006 ± 0.001 and 6.125 ± 0.541 µg/mL (Escherichia coli 57), 0.003 ± 0.001 and 6.125 ± 0.068 µg/mL (Klebsiella pneumoniae), 0.001 ± 0.0 and 6.125 ± 0.046 µg/mL (Pseudomonas aeruginosa) and 0.012 ± 0.003 and 6.125 ± 0.571 µg/mL (Staphylococcus aureus), respectively. MIC values of essential oil and hydrolat vs. both C. albicans and S. cerevisiae were lower than 1/20,480 µg/mL. Based on the findings obtained, essential oils of Withania frutescens can be used as promising natural agents to fight free radical damage and nosocomial antibiotic-resistant microbes.
Research on Contactless Bio-Signal Measurement Technology for Improving Social Awareness of Individuals with Communication Challenges
Authors: Nam Seonghyeon , Song Hayoung , Kim Youngwon
Published: June 2021

Youth and adults with autism spectrum disorder have poor skills such as communication, qualitative interaction, and emotional expression resulting in low social awareness. In this paper, we propose and explore a contactless bio-signal measurement and functional contents for improving social awareness of individuals with communication challenges. We implemented four individual methods for collecting and analyzing the bio data of the individuals without requiring their attention: (1) heart rate, (2) respiration, (3) facial expression, and (4) interaction. The four techniques are all based on image data received and analyzed from a normal web camera. The data were analyzed in a real-time, fully functional algorithm: implementing the algorithm on a mobile device will require future work. However, we have evaluated our method by developing a functional content including the four methods. Based on the analysis of the collected data from the content and qualitative responses from the field, the contactless bio-signal measurement technology combined with friendly designed user interfaces for the individuals with communication challenges could train them to improve their social awareness.
Special Issue “Applications of Finite Element Modeling for Mechanical and Mechatronic Systems”
Authors: Krawczuk Marek , Palacz Magdalena
Published: June 2021

Modern engineering practice requires advanced numerical modeling because, among other things, it reduces the costs associated with prototyping or predicting the occurrence of potentially dangerous situations during operation in certain defined conditions. Different methods have so far been used to implement the real structure into the numerical version. The most popular have been variations of the finite element method (FEM). The aim of this Special Issue has been to familiarize the reader with the latest applications of the FEM for the modeling and analysis of diverse mechanical problems. Authors are encouraged to provide a concise description of the specific application or a potential application of the Special Issue.
A Method to Minimize the Effort for Damper–Blade Matching Demonstrated on Two Blade Sizes
Authors: Gastaldi Chiara , Gola Muzio M.
Published: June 2021

A method called PCR (Platform Centered Reduction) is designed to more effectively perform complex iterative and nonlinear calculations required for the dynamic response of turbine blades damped by dry friction contacts between rigid dampers and airfoil-to-neck platform. The key feature of PCR is to represent all nonlinear forces on the blade platform by means of only six degrees of freedom at a point located within the platform volume, regardless of the number of damper–platform contact elements. Despite reducing the effort and computational time by more than one order of magnitude, the method proves to be fully accurate by a check against the corresponding nonlinear Finite Elements (FE) calculation. It is also shown that the limit exciting force, indicating the upper capability to dampen vibrations, can be calculated with a simple linear modal analysis. In order to search for the best blade–damper match, the preferred graph represents relevant bending stresses on the airfoil against excitation forces. A detailed application of the method concerns two significantly different blade sizes, by varying parameters such as neck length and damper centrifugal force. Finally, it is emphasized that a final check by a complete FE analysis is still possible as a purely linear solution fed by sets of contact forces previously determined through the PCR at any desired frequency and excitation.
An Approach to Build e-Health IoT Reactive Multi-Services Based on Technologies around Cloud Computing for Elderly Care in Smart City Homes
Authors: Jurado Pérez Luis , Salvachúa Joaquín
Published: June 2021

Although there are e-health systems for the care of elderly people, the reactive characteristics to enhance scalability and extensibility, and the use of this type of system in smart cities, have been little explored. To date, some studies have presented healthcare systems for specific purposes without an explicit approach for the development of health services. Moreover, software engineering is hindered by agile management challenges regarding development and deployment processes of new applications. This paper presents an approach to develop health Internet of Things (IoT) reactive applications that can be widely used in smart cities for the care of elderly individuals. The proposed approach is based on the Rozanski and Woods’s iterative architectural design process, the use of architectural patterns, and the Reactive Manifesto Principles. Furthermore, domain-driven design and the characteristics of the emerging fast data architecture are used to adapt the functionalities of services around the IoT, big data, and cloud computing paradigms. In addition, development and deployment processes are proposed as a set of tasks through DevOps techniques. The approach validation was carried out through the implementation of several e-health services, and various workload experiments were performed to measure scalability and performance in certain parts of the architecture. The system obtained is flexible, scalable, and capable of handling the data flow in near real time. Such features are useful for users who work collaboratively in the care of elderly people. With the accomplishment of these results, one can envision using this approach for building other e-health services.