bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiotherapy and breast cancer: finally, an lncRNA perspective on radiosensitivity and radioresistance
Authors: Yazarlou Fatemeh , Martinez Ivan , Lipovich Leonard
Published: September 2024

Radiotherapy (RT) serves as one of the key adjuvant treatments in management of breast cancer. Nevertheless, RT has two major problems: side effects and radioresistance. Given that patients respond differently to RT, it is imperative to understand the molecular mechanisms underlying these differences. Two-thirds of human genes do not encode proteins, as we have realized from genome-scale studies conducted after the advent of the genomic era; nevertheless, molecular understanding of breast cancer to date has been attained almost entirely based on protein-coding genes and their pathways. Long non-coding RNAs (lncRNAs) are a poorly understood but abundant class of human genes that yield functional non-protein-coding RNA transcripts. Here, we canvass the field to seek evidence for the hypothesis that lncRNAs contribute to radioresistance in breast cancer. RT-responsive lncRNAs ranging from “classical” lncRNAs discovered at the dawn of the post-genomic era (such as HOTAIR, NEAT1, and CCAT), to long intergenic lncRNAs such as LINC00511 and LINC02582, antisense lncRNAs such as AFAP-AS1 and FGD5-AS1, and pseudogene transcripts such as DUXAP8 were found during our screen of the literature. Radiation-related pathways modulated by these lncRNAs include DNA damage repair, cell cycle, cancer stem cells phenotype and apoptosis. Thus, providing a clear picture of these lncRNAs’ underlying RT-relevant molecular mechanisms should help improve overall survival and optimize the best radiation dose for each individual patient. Moreover, in healthy humans, lncRNAs show greater natural expression variation than protein-coding genes, even across individuals, alluding to their exceptional potential for targeting in truly personalized, precision medicine.
Alveolar type 2 cells marker gene SFTPC inhibits epithelial-to-mesenchymal transition by upregulating SOX7 and suppressing WNT/β-catenin pathway in non-small cell lung cancer
Authors: Zhang Qiongyin , An Ning , Liu Yang , Zhu Ying , Pan Wuliang , Gu Peiling , Zhao Jinzhu , Pu Qiang , Zhu Wen
Published: September 2024

Introduction

Surfactant Protein C gene (SFTPC) is a marker gene of alveolar type 2 cells (AT2), which are the key structures of alveoli. Mutations or deletions in SFTPC cause idiopathic pulmonary fibrosis (IPF). Importantly, IPF is an independent risk factor for non-small cell lung cancer (NSCLC). It suggests that abnormal expression of SFTPC may be relevant to development of NSCLC. However, the function and mechanism of SFTPC in NSCLC are still poor understood until now.

Methods

The expression of SFTPC and the relationship between SFTPC and prognosis of NSCLC were analyzed in TCGA database and our collected clinical NSCLC tissues. Subsequently, the function and mechanism of SFTPC in NSCLC were explored by RNA-sequence, qRT-PCR, Western blot, Immunohistochemical, Wound-healing, Millicell, Transwell assays and mouse tumor xenograft model.

Results

SFTPC was dramatically downregulated in NSCLC tissues from TCGA database and 40 out of 46 collected clinical LUAD tissues compared with adjacent non-tumor tissues. Low expression of SFTPC was associated with poor prognosis of LUAD by TCGA database. Importantly, we confirmed that overexpression of SFTPC significantly inhibited Epithelial-to-Mesenchymal Transition (EMT) process of NSCLC cells by upregulating SOX7 and then inactivating WNT/β-catenin pathway in vitro and in vivo. Particularly, we discovered that low expression of SFTPC was associated with EMT process and low expression of SOX7 in NSCLC tissues.

Conclusion

Our study revealed a novel mechanism of SFTPC in NSCLC development. Meanwhile, it also might provide a new clue for exploring the molecular mechanism about NSCLC development in patients with IPF in the future.
Radiotherapy can improve overall survival in patients with lymph-node positive, high-grade neuroendocrine cervical cancer: construction of two prognostic nomograms to predict treatment outcome
Authors: Zhang Siying , Li Qinke , Ouyang Xiping , Tang Ya , Cui Ji , Yang Zhu
Published: September 2024

Background

To explore the beneficial subgroups after radiotherapy in high-grade neuroendocrine cervical cancer (HGNECC) and construct two survival prognosis models to quantify the efficacy of radiotherapy assessment.

Methods

In this retrospective study, we included 592 eligible samples from the Surveillance, Epidemiology, and End Results (SEER) database and 56 patients with lymph-node positive HGNECC from Chongqing Medical University. Cox regression analysis was used to identify independent survival prognosis risk factors for HGNECC patients. Propensity score matching (PSM) was employed as it balances the baseline differences among grouping methods. Kaplan–Meier (K-M) curves were used to analyze survival differences among different groups. Two survival prediction nomograms were constructed separately (using the "rms" package in R software) based on whether radiotherapy was administered. The stability and accuracy of these models were assessed using receiver operating characteristic (ROC) curves and calibration curves in both the training and validation datasets. P<0.05 was considered to indicate statistically significant differences.

Results

Age, Federation of Gynecology and Obstetrics (FIGO)-stage, and treatment methods (surgery vs. chemotherapy) were independent risk factors that affected survival prognosis (P<0.05). Radiotherapy showed adverse effects on survival in patients with early tumor staging, lymph-node negative status, and absence of distant metastasis (all P<0.05). The lymph-node positive group had a beneficial response to radiotherapy (P<0.05), and patients with metastasis in the radiotherapy group showed a survival protection trend (P=0.069).

Conclusion

In HGNECC, patients with lymph-node positive status can benefit from radiotherapy in terms of survival outcomes. We constructed two survival prediction models based on whether radiotherapy was administered, thereby offering a more scientifically guided approach to clinical treatment planning by quantifying the radiotherapy efficacy.
Mediation role of cardiorespiratory fitness on association of physical activity and physical literacy among 8–12 years old children: the PAK-IPPL cross-sectional study
Authors: Hadier Syed Ghufran , Yinghai Liu , Long Liu , Hamdani Syed Danish , Hamdani Syed Muhammad Zeeshan Haider
Published: September 2024

Background

The effect of cardiorespiratory fitness (CRF) on the relationship of physical activity (PA), and physical literacy (PL) in 8–12 Pakistani children are largely unknown. Therefore, this study aims to examine the mediating role of CRF in the relationship between PA and PL in this demographic.

Methods

This cross-sectional study involved 1,360 children aged 8–12 (mean age = 10.00, SD = 1.41 years) from 85 higher secondary schools in South Punjab, Pakistan. Data were collected during the 2020–2021 academic year using the Canadian Assessment of Physical Literacy-2 (CAPL-2) protocol to assess physical activity (PA), Body Mass Index (BMI), and PL levels. CRF was measured using the PACER (Progressive Aerobic Cardiovascular Endurance Run) test. Descriptive statistics, independent samples t-tests, Chi-squared tests, and Generalized Additive Models for Location, Scale, and Shape (GAMLSS) were used for age and sex-specific CAPL-2 scoring. Associations among components were evaluated through Pearson's correlation, multivariate logistic regression, and mediation analyses.

Results

The study revealed that boys had significantly higher scores in CRF, PA, and PL across all age groups compared to girls (p < 0.001), with boys' scores being 20%, 10%, and 14% higher, respectively, than those of girls. Conversely, overweight children showed significantly reduced PA and PL levels (p < 0.001). An inverse correlation was found between BMI and CRF (r2 linear = 0.022; quadratic = 0.028). CRF scores had significant negative correlations BMI (r = −0.143) and positive associations with MVPA, PA, DB, and PL (r ranging from 0.241 to 0.624). CRF was observed to partially mediate the association between MVPA and PL. The direct impact of PA on PL was significant and meaningful (β = 0.002, p < .001). Additionally, the indirect effect of PA on PL through CRF was also significant (β = 0.001, p < .001), indicating that CRF serves as an important mediator in this relationship. The combined total effect of PA on PL, which includes both direct and mediated pathways, was robust and highly significant (β = 0.003, p < .001).

Conclusion

The study revealed a strong positive correlation between CRF, PA, and PL, but a negative one with BMI in South Punjab children aged 8–12. Notably, CRF and PA emerged as significant predictors of PL levels in this population. Consequently, interventions that are both systematic and targeted towards improving these factors should be implemented as strategies to enhance children's PL levels and promote physically active behaviors.
Combination effects of environmental tobacco smoke exposure and nutrients supplement during pregnancy on obesity in Chinese preschool children
Authors: Zhang Wen-Xuan , Strodl Esben , Yang Wei-Kang , Yin Xiao-Na , Wen Guo-Min , Sun Deng-Li , Xian Dan-Xia , Zhao Ya-Fen , Chen Wei-Qing
Published: September 2024

Objective

This study aimed to explore the combination effects of prenatal exposure to environment tobacco smoke (ETS) and nutrients supplement during pregnancy on childhood obesity in preschoolers.

Methods

A cross-sectional study was conducted with 58,814 child-mother dyads from 235 kindergartens in Longhua District of Shenzhen, China in 2021. A self-administered structured questionnaire was completed by mothers to collect socio-demographic characteristics, prenatal ETS exposure, and nutrients supplement in pregnancy, and preschoolers' heights and weights were measured at the same time. After controlling for potential confounding variables, logistic regression models and cross-analyses were used to examine the independent and combination effects of maternal prenatal ETS exposure and nutrients supplementation during pregnancy on obesity in preschool children.

Results

The results of our study showed that prenatal ETS exposure increased the risk of childhood obesity (AOR = 1.22, 95% CI = 1.11–1.34) in preschoolers. In addition, risk of childhood obesity was significantly higher when mothers didn't take supplements of multivitamins (AOR = 1.12, 95% CI = 1.05–1.20), folic acid (AOR = 1.23, 95% CI = 1.10–1.37) and iron (AOR = 1.11, 95% CI = 1.04–1.19) during pregnancy. The cross-over analysis showed that the combination of prenatal ETS exposure with mothers taking no multivitamins (AOR = 1.40, 95% CI = 1.21–1.62), no folic acid (AOR = 1.55, 95% CI = 1.12–2.14) and no iron (AOR = 1.38, 95% CI = 1.19–1.59) during pregnancy also increased the risk of obesity among Chinese preschoolers. We also discovered additive interactive effects between prenatal ETS exposure and no maternal multivitamin, folic acid and iron supplementation in pregnancy on the risk of obesity in preschoolers.

Conclusion

The combination of prenatal exposure to ETS with no supplementation of these nutrients might jointly increase the risk of childhood obesity. Public health interventions are needed to reduce prenatal exposure to ETS and to encourage mothers to take appropriate multivitamin, folic acid and iron supplements during pregnancy.
The possible anti-tumor actions and mechanisms of active metabolites from Cortex Fraxini
Authors: Cai Bin , Cai Ting , Feng Zeyu , Zhu Huanhuan
Published: September 2024

Cortex Fraxini is a traditional Chinese herb that is widely available, inexpensive, and has low toxicity. Modern pharmacological studies have demonstrated that the active metabolites in Cortex Fraxini, including esculin, esculetin, and fraxetin, exert anti-tumor activities by regulating genes and proteins involved in cancer cell proliferation, apoptosis, invasion, and migration. Additionally, these metabolites play a pivotal role in the regulation of several tumor-associated signaling pathways, including the PI3K/Akt, MAPK/ERK, JAK/STAT3, and Wnt/β-catenin pathways. Due to their pro-apoptotic and anti-proliferative properties in vitro and in vivo, Cortex Fraxini and its active metabolites may be considered as potential candidates for the treatment of tumor. The aim of this review is to highlight the anti-tumor biological activities and underlying mechanisms of action of the active metabolites of Cortex Fraxini, with a view to providing a reference for their further development and application in the treatment of tumors.
The impact of a multidisciplinary team intervention on medication prescription in nursing homes in Catalonia
Authors: Anderssen-Nordahl Emilie , Fernández-Liz Eladio , Sabaté Gallego Mònica , Bosch Ferrer Montserrat , Sánchez-Arcilla Rosanas Margarita , Cervera León Mercè , Magrinyà Joaquim Miquel , Barceló-Colomer Maria Estrella
Published: September 2024

Background

In response to the rising population of nursing home residents with frailty and multimorbidity, optimizing medication safety through drug utilization review and addressing medication-related problems (MRPs) is imperative. Clinical decision support systems help reduce medication errors and detect potential MRPs, as well as medication reviews performed by a multidisciplinary team, but these combined assessments are not commonly performed. The objective of this study was to evaluate the impact on medication plans of a multidisciplinary team intervention in nursing homes, by analyzing the medication plan before and after the intervention and assessing whether the recommendations given had been implemented.

Methods

A multicenter before-after study, involving five nursing homes, assessed the impact of a multidisciplinary team intervention, to estimate effectiveness related to the review of the prescribed medications. The follow-up period for each patient was 12 months or until death if prior, from July 2020 to February 2022, and involved 483 patients. The clinical pharmacologist coordinated the intervention and reviewed all the prescribed medications to make recommendations, focused on the completion of absent data, withdrawal of a drug, verification of whether a drug was adequate, the substitution of a drug, and the addition of drugs. Since the intervention was performed during the COVID-19 pandemic, optimization of psychotropic drugs and absorbent pads were limited.

Results

The intervention had an impact with recommendations given for 398 (82.4%) of the patients and which were followed by 58.5% of them. At least one drug was withdrawn in 293 (60.7%) of the patients, with a mean of 2.3 (SD 1.7). As for the total of 1,097 recommendations given, 355 (32.4%) were followed. From the intervention, antipsychotics, antidepressants, benzodiazepines, statins, and diuretics were the most frequently withdrawn.

Conclusion

The findings underscore the impact of targeted interventions to reduce inappropriate medications and enhance medication safety in nursing homes. The proposed recommendations given and followed show the importance of a multidisciplinary team, coordinated by a clinical pharmacologist, for a patient-centered approach to make medication reviews regularly, with the help of clinical decision support systems, to help reduce potential MRPs and polypharmacy.
Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis
Authors: Borho Joscha , Kögel Merle , Eckert Amelie , Barth Holger
Published: September 2024

Many bacteria act pathogenic by the release of AB-type protein toxins that efficiently enter human or animal cells and act as enzymes in their cytosol. This leads to disturbed cell functions and the clinical symptoms characteristic for the individual toxin. Therefore, molecules that directly target and neutralize these toxins provide promising novel therapeutic options. Here, we found that the FDA-approved drug disulfiram (DSF), used for decades to treat alcohol abuse, protects cells from intoxication with diphtheria toxin (DT) from Corynebacterium diphtheria, the causative agent of diphtheria, lethal toxin (LT) from Bacillus anthracis, which contributes to anthrax, and C2 enterotoxin from Clostridium botulinum when applied in concentrations lower than those found in plasma of patients receiving standard DSF treatment for alcoholism (up to 20 µM). Moreover, this inhibitory effect is increased by copper, a known enhancer of DSF activity. LT and C2 are binary toxins, consisting of two non-linked proteins, an enzyme (A) and a separate binding/transport (B) subunit. To act cytotoxic, their proteolytically activated B subunits PA63 and C2IIa, respectively, form barrel-shaped heptamers that bind to their cellular receptors and form complexes with their respective A subunits LF and C2I. The toxin complexes are internalized via receptor-mediated endocytosis and in acidified endosomes, PA63 and C2IIa form pores in endosomal membranes, which facilitate translocation of LF and C2I into the cytosol, where they act cytotoxic. In DT, A and B subunits are located within one protein, but DT also forms pores in endosomes that facilitate translocation of the A subunit. If cell binding, membrane translocation, or substrate modification is inhibited, cells are protected from intoxication. Our results implicate that DSF neither affects cellular binding nor the catalytic activity of the investigated toxins to a relevant extend, but interferes with the toxin pore-mediated translocation of the A subunits of DT, LT and C2 toxin, as demonstrated by membrane-translocation assays and toxin pore conductivity experiments in the presence or absence of DSF. Since toxin translocation across intracellular membranes represents a central step during cellular uptake of many bacterial toxins, DSF might neutralize a broad spectrum of medically relevant toxins.
Free energy calculations in biomolecule-nanomaterial interactions
Authors: Fu Hongze , Zhu Yinbang , Chen Qu
Published: September 2024

In computational chemistry and molecular modeling, the interactions between biomolecules (BMs) and nanomaterials (NMs) play a crucial role in various physical and biological processes, and have significant implications in material discovery and development. While there is extensive literature on free energy calculations for drug-target interactions, reviews specifically addressing BM-NM interactions are relatively scarce. This manuscript aims to fill in this gap by presenting a comprehensive overview of the most widely used and well-established methods for free energy calculations. It provides a detailed analysis of the advantages and limitations of these methods and discusses their applicability to BM-NM systems. This work is intended to offer insights into free energy calculations and serve as a guide for future research in this field.
A comprehensive review of training methods for physical demands in adolescent tennis players: a systematic review
Authors: Guo Yuxin , Xie Jia , Dong Gengxin , Bao Dapeng
Published: September 2024

Background

Adolescent tennis players encounter critical physical demands, but the lack of comprehensive analysis of training types hampers the selection of optimal training programs. This study aims to conduct a systematic literature review to analyze the effectiveness and limitations of various training types on the physical demands of adolescent tennis players, summarizing the optimal training methods to enhance these physical qualities.

Methods

From March 2024, a comprehensive search was conducted across four electronic databases: SCOPUS, PubMed, EBSCOhost (SPORTDiscus), and Web of Science. Additionally, Google Scholar and other sources of gray literature were referenced. Original research articles with an experimental design were included. The methodological quality of the included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale, and the overall scientific evidence was determined through the best evidence synthesis (BES).

Results

Eighteen articles on exercise training met all inclusion criteria and were included in this systematic review. These studies maintained a high standard of quality, making their findings relatively credible. Among them, five studies investigated plyometric training, five focused on neuromuscular training, three explored functional training, two examined traditional strength training, and three assessed High-Intensity Interval Training.

Conclusion

To enhance speed, strength, power, agility, and dynamic balance, it is recommended to prioritize plyometric training, neuromuscular training, and functional training over traditional tennis training. Functional training is particularly effective for improving flexibility and balance, while plyometric training is more suited for increasing power and speed. Neuromuscular training, when performed before routine workouts, is beneficial for enhancing speed, flexibility, and strength. Hard surface training is ideal for boosting power, whereas sand training excels in improving strength, speed, and balance. Combining HIIT with strength training is especially advantageous for enhancing short-distance sprinting, repeated sprint ability, and power. By appropriately combining and utilizing these training methods, the physical capabilities and sports performance of adolescent tennis players can be comprehensively optimized.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42024578147.
Genome-wide identification of the GATA gene family in melon (Cucumis melo) and analysis of their expression characteristics under biotic and abiotic stresses
Authors: Zheng Ling , Tang Lin , Li Jinbo
Published: September 2024

GATA transcription factors are an important class of transcription factors in plants, known for their roles in tissue development, signal transduction, and responses to biotic and abiotic stresses. To date, there have been no reports on the GATA gene family in melon (Cucumis melo). In this study, 24 CmGATA genes were identified from the melon genome. These family members exhibit significant differences in protein length, molecular weight, and theoretical isoelectric point and are primarily located in the nucleus. Based on the classification of Arabidopsis thaliana GATA members, the phylogenetic tree divided them into four groups: group I, group II, group III, and group IV, containing 10, 8, 4, and 2 genes, respectively. Notably, CmGATA genes within the same group have highly conserved protein motifs and similar exon–intron structures. The CmGATA family members are unevenly distributed across 10 chromosomes, with six pairs of segmentally duplicated genes and one pair of tandemly duplicated genes, suggesting that gene duplication may be the primary factor in the expansion of the CmGATA family. Melon shares 21, 4, 38, and 34 pairs of homologous genes with A. thaliana, Oryza sativa, Cucumis sativus, and Citrullus lanatus, respectively. The promoter regions are enriched with various cis-acting elements related to growth and development (eight types), hormone regulation (nine types), and stress responses (six types). Expression patterns indicate that different CmGATA family members are significantly expressed in seeds, roots, stems, leaves, tendrils, mesocarp, and epicarp, exhibiting distinct tissue-specific expression characteristics. Quantitative fluorescence analysis revealed that five genes, CmGATA3, CmGATA7, CmGATA16, CmGATA22, and CmGATA24, may be highly active under 48-h drought stress, while CmGATA1 and CmGATA22 may enhance melon resistance to heavy metal lead stress. Additionally, CmGATA22 and CmGATA24 are suggested to regulate melon resistance to Fusarium wilt infection. CmGATA22 appears to comprehensively regulate melon responses to both biotic and abiotic stresses. Lastly, potential protein interaction networks were predicted for the CmGATA family members, identifying CmGATA8 as a potential hub gene and predicting 2,230 target genes with enriched GO functions. This study preliminarily explores the expression characteristics of CmGATA genes under drought stress, heavy metal lead stress, and Fusarium wilt infection, providing a theoretical foundation for molecular mechanisms in melon improvement and stress resistance.
Effects of multisession prefrontal cortex tDCS or taVNS on stress, perceived stress and sleep quality: a double-blind, randomized controlled study
Authors: dos Reis Laya Dalila , Pereira Generoso Laura , Pereira Gabrielly Santos , Teixeira Barú João Paulo da Silva , Candido Natalie Lange , Maziero Capello Maria Gabriela , de Castro Renato Ortolani Marcondes , Cardoso Edvaldo José Rodrigues , Scoz Robson Dias , Ferreira Luciano Maia Alves , da Silva Marcelo Lourenço , da Silva Josie Resende Torres
Published: September 2024

Introduction

Chronic stress is a condition characterized by prolonged stimulation, leading to mental and physical weakness. It can have detrimental effects on individuals’ mental health and cognitive function, potentially causing various health issues. This article explores the potential of non-invasive neuromodulation techniques, specifically transcranial direct current stimulation (tDCS) and transcutaneous auricular vagus nerve stimulation (taVNS), in managing chronic stress and improving sleep quality.

Methods

The study conducted a randomized, double-blinded, controlled trial with participants experiencing chronic stress. In total, 100 participants were randomly assigned to one of four conditions: the anodal tDCS group (n = 50), the sham tDCS group (n = 50), the taVNS group (n = 50), or the sham taVNS group (n = 50). Within each condition, participants received five sessions of either active treatment or sham treatment, with 20 min of tDCS over the dorsolateral prefrontal cortex (2 mA) for the tDCS groups, or taVNS on the left ear (20 Hz) for the taVNS groups. At baseline, post-intervention, and 4 weeks thereafter, we evaluated stress using the Lipp’s Inventory of Stress Symptoms for Adults (LSSI), perceived stress through the Perceived Stress Scale (PSS-10), and sleep quality via the Pittsburgh Sleep Quality Index (PSQI).

Results

The tDCS and taVNS interventions resulted in reduced stress levels, improved sleep quality, and enhanced perception of stress.

Discussion

These findings suggest that tDCS and taVNS hold promise as effective treatments for chronic stress, offering a safe and accessible approach to improving individuals’ wellbeing and overall quality of life.

Clinical trial registration

https://ensaiosclinicos.gov.br/rg/RBR-2ww2ts8, identifier UTN: U1111-1296-1810; Brazilian Registry of Clinical Trials (REBEC) RBR-2ww2ts8.
L1 grammatical attrition through the acquisition of competing L2 discourse features
Authors: Smeets Liz
Published: September 2024

A question in language acquisition research is whether attrition can affect L1 grammatical representation, and if so, under what conditions. This paper tests the Attrition via Acquisition (AvA) model, which takes a Feature Reassembly approach to predict how, in case on high degrees of similarity between the L1 and L2, the acquisition of L2 discourse-driven morpho-syntactic properties may affect L1 feature representations after a prolonged change in the speaker’s primary linguistic input during adulthood. As a test case, we use the different features (specificity versus discourse anaphoricity) associated with Clitic Left Dislocation (CLLD) in Romanian and Italian, examining the grammars of Romanian first-generation immigrants with either L2 Italian or L2 English (a language without CLLD). Using a context-dependent Acceptability Judgment task and a Written Elicitation task we found evidence for L2-induced grammatical attrition, resulting in the addition of an L2 option without the loss of an L1 option, as predicted by the AvA. Attrition was found for participants who immigrated during adolescence or early adulthood and who are more likely to consider Italian their most proficient and most used language. We compare our findings on attrited L1 grammars to the results of a recent study reporting on near-native L2 Italian and L2 Romanian grammars by Romanian and Italian native speakers. Our findings contribute to an increasing body of literature showing that L1 attriters and L2 learners can end up with very similar grammars and confirm the importance of studying second language acquisition and L1 loss within a broader picture of bilingual development.
Mood states and well-being of spouses of fibromyalgia patients: a systematic review and meta-analysis
Authors: Treister-Goltzman Yulia , Peleg Roni
Published: September 2024

Background

We carried out a systematic review of the medical literature on potential effects of caregiving on the health and well being of spouses of Fibromyalgia (FM) patients and pooled the results in a meta-analysis.

Methods

The review is comprised of original studies that examined the mood states and well-being of husbands/wives, or long-term intimate partners, of FM patients. The authors searched the PubMed, Scopus, APA PsycNet and Web of Science databases using the key words “fibromyalgia and spouses,” “fibromyalgia and partners,” and “fibromyalgia and husbands.” Of 570 papers that were initially identified using the search words, 18 papers were considered eligible. We used the Joanna Briggs Institute Critical Appraisal Checklist (JBICAC) and Critical Appraisal Skills Program (CASP) tools to assess the risk of bias in the analytical cross-sectional and qualitative studies, respectively.

Results

The overall score in mood states was significantly higher among spouses of FM patients than among spouses of individuals without FM (SMD [95% CI] = 0.52 [0.30; 0.74]). The strongest evidence was found for depression, SMD [95% CI] = 0.68 [0.33; 1.03]. The overall standardized score of quality of life was significantly lower among spouses of FM patients, SMD [95% CI] = −0.59 [−0.79; −0.38], with significant differences in physical function and role, emotional role, and mental health subscales.

Limitation

Limitation of this review is the scant number of studies that addressed several health domains, which made it impossible to carry out meta-analyses in these domains.

Conclusion

Spouses of FM patients show the emotional and physical consequences of caregiving, and impaired quality of life. Addressing these problems can prevent deterioration of their health and improve their quality of life.
Validation of the personal suicide stigma questionnaire among adolescents with suicide attempts in mainland China
Authors: Wang Xiaoning , Miao Qunfang , Wang Jiannv , Qiu Lingjing , Zhang Jinsheng , Li Peiqing , Huang Yaoyao
Published: September 2024

Objectives

The study aimed to translate and culturally adapt the personal suicide stigma questionnaire (PSSQ) into simplified Chinese and evaluate its psychometric properties among adolescents who have attempted suicide in mainland China.

Methods

Following Brislin’s translation model and using purposive sampling, we surveyed 440 adolescents who had attempted suicide at Hangzhou Seventh People’s Hospital in Zhejiang Province, China. Content validity was determined by a panel of experts, and the construct validity of the scale was assessed using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), convergent validity, and discriminant validity. Reliability analysis was evaluated using Cronbach’s α coefficient, test–retest reliability, and half-split reliability.

Results

The Chinese version of the PSSQ consists of three dimensions and 14 items. After two rounds of expert consultation, the item-content validity index for all items exceeded 0.70, and the scale-content validity index exceeded 0.90. EFA extracted three factors and retained all 14 items. The CFA indicators demonstrated a good fit. The Cronbach’s α coefficient of the scale was 0.880, the half-split reliability was 0.681, and the test–retest reliability was 0.862. It is evident that the PSSQ and its subscales demonstrate stable structural validity and good internal consistency in measuring self-stigma among individuals with suicidal tendencies, indicating that the PSSQ is a reliable tool for assessing the degree of personal stigma in Chinese adolescents who have attempted suicide.

Conclusion

This study ensured the linguistic and cultural appropriateness of the Chinese version of the PSSQ through cross-cultural adaptation and validation of its reliability and validity, thereby enhancing the accuracy and reliability of assessing personal stigma among Chinese adolescents who have attempted suicide. The validation of the Chinese version of the scale not only enriches the research tools available for studying personal stigma related to suicide in mainland China, but also provides a reliable quantitative tool for future research on the psychological states of individuals who have attempted suicide, the impact of stigma, and the effectiveness of interventions.
Factors associated with self-management in older adults with multiple chronic conditions: a qualitative study
Authors: Sadeghi Hajar , Mohammadi Shahbolaghi Farahnaz , Hosseini Mohammadali , Fallahi-Khoshknab Masoud , Ghaedamini Harouni Gholamreza
Published: September 2024

Background and purpose

Recognizing the importance of self-management in older adults with multiple chronic conditions (MCCs) is crucial for their quality of life. This qualitative study explored the factors linked to self-management among older adults with MCCs.

Materials and methods

The present study was conducted in three stages: an integrated review, qualitative interviews, and Delphi. The search used electronic databases including Web of Science, PubMed, Scopus, Magiran, SID, and Iranmedex. The results of 33 studies that met the inclusion criteria were analyzed using conventional content analysis. A data matrix was formed; and purposeful sampling was conducted among older adults with MCCs, family caregivers, and specialists. The data were collected through semi-structured interviews. Data analysis of 29 interviews was conducted simultaneously with data collection using oriented qualitative content analysis and the Elo and Kyngäs approach. Three rounds of Delphi were conducted via email correspondence with a group of 30 experts to develop and validate the proposed variables.

Results

The factors that influence self-management can be categorized into various categories. Biological factors, cognitive factors, co-morbidities, socio-economic factors, health-related behaviors, mental health, interactions with healthcare teams, Family relationships, medical facility resources, employee empowerment, health policy development, and cultural influences.

Conclusion

Self-management in older Iranian adults with MCCs is a complex and multidimensional phenomenon. By identifying the relevant factors, it is possible to design operational plans that promote self-management among the older adult population and are tailored to fit the specific needs of Iranian society.
Growth and development and trends in overweight and obesity among 7–12 years old Hmong children in China: an analysis of eight successive national surveys from 1985 to 2019
Authors: Pan Qi , Li Yuyu , Chen Xiaolong , Dai Xinyi , Zhang Xueliang , Tu Chunjing
Published: September 2024

Background

To explore the dynamic changes and trends in the body shape of Hmong children aged 7–12 years from 1985 to 2019, and to predict them, to provide a reference for the physical health level of Hmong children.

Methods

The body shape data of Hmong children aged 7–12 years old from the Chinese National Survey on Students’ Constitution and Health (CNSSCH) in 1985, 1991, 1995, 2000, 2005, 2010, 2014, and 2019 were used for longitudinal comparative analysis, and the grey GM(1,1) model was established based on this as a time series. Forecast the future development trend in 2025 and 2030.

Results

1) From 1985 to 2019, all indicators of body shape of Hmong primary school students showed an upward trend, the increase in height (FBoys = 3.91, p > 0.05; FGirls = 3.91, p > 0.05), weight (FBoys = 8.04, p < 0.01; FGirls = 6.36, p < 0.05) and BMI (FBoys = 19.15, p < 0.01; FGirls = 10.24, p < 0.01) increased with age, rate of growth: Weight > BMI > Height, girls grow faster than boys; 2) The prevalence of overweight and obesity increased year by year, from 5.2 and 1.2% in 1991 to 12.4% (χ2linear trend = 3.89, p < 0.05) and 8.7% (χ2linear trend = 3.98, p < 0.05) in 2014, respectively, showing a significant growth trend, especially after 2000, overweight and obesity have entered a stage of rapid growth; 3) The forecast results show that the height, weight and BMI will continue to increase in 2025 and 2030, but the growth rate will decrease, the increase of weight and BMI is greater than the height, overweight and obesity are still expected to increase rapidly.

Conclusion

The growth and development level of Hmong elementary children continues to increase, and the prevalence of overweight and obesity is increasing year by year, requiring early prevention and intervention to promote the healthy development of physical fitness of Hmong, as well as other ethnic minority students.
Longitudinal associations between leisure activities and subjective happiness among middle-aged and older adults people in China: national cohort study
Authors: Feng Chengkai , Shi Zhenguo , Tian Yuge , Ma Chao , Sun Qian
Published: September 2024

Background

Leisure activities serve as key measures to enhance the subjective happiness of middle-aged and older adults individuals and to positively address the challenges of an aging society; however, the trajectory of changes in their participation in leisure activities and how these changes relate to shifts in subjective happiness have not been adequately explored.

Methods

This study selected data from the China Health and Aging Longitudinal Study (CHARLS), which included a total of 5,190 middle-aged and older adults people. Linear and nonlinear latent growth models, parallel latent growth models and cross-lagged models were constructed to investigate the influence and lagged relationship between the trajectory of changes in the level of participation in leisure activities on the trajectory of changes in the subjective well-being of middle-aged and older adults people.

Results

The initial level of physical activity participation of middle-aged and older adults people significantly predicted the initial level (β = 1. 203, p < 0.001) and rate of change (β = −0.138, p = 0.016) of their subjective well-being, and the trajectory of change of middle-aged and older adults people’s physical activity also significantly predicted the rate of change of their subjective well-being (β = 0.582, p = 0.003). Meanwhile, the initial level of social activity of middle-aged and older adults people also effectively predicted the initial level of their subjective well-being (β = 0.048, p < 0.001). At the same time, the covariates (gender, age, level of education, marital status, chronic disease) also predicted the initial level and rate of change of leisure activity participation level and subjective well-being. Finally, the cross-lagged model test confirmed the predictive effect of leisure activity participation level on subjective well-being of middle-aged and older adults people.

Conclusion

This study confirms that the level of participation in leisure activities of Chinese middle-aged and older adults people has a significant predictive effect on their subjective happiness and that there is a significant correlation between the trajectory of changes in the level of participation in leisure activities and the trajectory of changes in subjective happiness.
The mediating effect of self-efficacy on the relationship between self-care ability and disability level in older adult patients with chronic diseases
Authors: Wang Tiemei , Wang Senlin , Wu Nianwei , Liu Yan
Published: September 2024

Objective

This study investigates the mediating effect of self-efficacy on the relationship between self-care ability and disability level in older adult patients with chronic diseases.

Methods

A convenience sampling method was used to select 372 older adult patients with chronic diseases from five tertiary hospitals in Chengdu, Sichuan Province. General demographic information was collected using a questionnaire, and self-efficacy, self-care ability, and disability were assessed using standardized scales. Data were analyzed using SPSS 26.0, and the PROCESS macro was employed to test the mediating effect of self-efficacy.

Results

The mean score for self-efficacy was 26.09 ± 7.20, for self-care ability was 113.19 ± 23.31, and for disability was 154.19 ± 29.32. Self-efficacy was positively correlated with self-care ability (r = 0.73, p < 0.001. and negatively correlated with disability (r = −0.84, p < 0.001. and self-care ability and disability (r = −0.91, p < 0.001.. The indirect effect of self-efficacy on the relationship between self-care ability and level of disability was −0.03 (95% CI −0.08 to −0.04), accounting for 16.67% of the total effect.

Conclusion

Self-efficacy partially mediates the relationship between self-care ability and disability in older adult patients with chronic conditions. Healthcare providers can improve self-care behaviours and self-efficacy in older adult patients through effective interventions to reduce the incidence of disability.
Exact linearization and control of a mobile robot for the inspection of soil resources in Solanum tuberosum crops
Authors: Pulido-Aponte Álvaro , Garzón-Castro Claudia L.
Published: September 2024

In recent years, the development of robots for agro-industrial applications, such as the cultivation of Solanum tuberosum potatoes, has aroused the interest of the academic and scientific communities. This is due, at least in part, to the complexity of modeling and robustly controlling some dynamics inherent to nonlinear behaviors normally attributed to the different technologies associated with the movement of these autonomous vehicles and their non-holonomic constraints. The different nonlinear dynamics of mobile robots are usually represented by state-space models. However, given some equilibrium and stability characteristics, the implementation of effective controllers for the robust parametric tracking and variation problem requires techniques that allow the operability of robots around regions of stable equilibrium. Feedback linearization control is one such technique that attempts to mathematically eliminate nonlinear expressions from the plant model. However, this technique requires an observable and controllable mathematical model. If there is some relationship between the model inputs and a controlled output that allows the relative degree of the control law to be determined, the controller design and implementation are posed as a linear issue. Flat filters developed from the generalized proportional integral control approach are an alternative that could facilitate the design of controllers for these linearized systems. From these flat filters, it is possible to obtain the transfer function of a controller without relying on the derivatives of the system output. This work proposes the design of a controller via exact linearization and its equivalent flat filter for a robot inspector of the soil resource of S. tuberosum crops in the department of Cundinamarca, Colombia. The actuator motion constraints resulted in a robot with two degrees of mobility and one non-holonomic constraint. Numerical validation of this system suggests that it can be an effective solution to the problem of tracking control at changing references by providing a system capable of navigating through crop rows. The results suggest correct tracking for linear and circular trajectories. However, the control lacks the ability to track spiral-type trajectories.
Light gradient boost tree classifier predictions on appendicitis with periodontal disease from biochemical and clinical parameters
Authors: Yadalam Pradeep Kumar , Thirukkumaran Prathiksha Vedhavalli , Natarajan Prabhu Manickam , Ardila Carlos M.
Published: September 2024

Introduction

Untreated periodontitis significantly increases the risk of tooth loss, often delaying treatment due to asymptomatic phases. Recent studies have increasingly associated poor dental health with conditions such as rheumatoid arthritis, diabetes, obesity, pneumonia, cardiovascular disease, and renal illness. Despite these connections, limited research has investigated the relationship between appendicitis and periodontal disease. This study aims to predict appendicitis in patients with periodontal disease using biochemical and clinical parameters through the application of a light gradient boost tree classifier.

Methods

Data from 125 patient records at Saveetha Institute of Dental College and Medical College were pre-processed and analyzed. We utilized data preprocessing techniques, feature selection methods, and model development approaches to estimate the risk of appendicitis in patients with periodontitis. Both Random Forest and Light Gradient Boosting algorithms were evaluated for accuracy using confusion matrices to assess their predictive performance.

Results

The Random Forest model achieved an accuracy of 94%, demonstrating robust predictive capability in this context. In contrast, the Light Gradient Boost algorithms achieved a significantly higher accuracy of 98%, underscoring their superior predictive efficiency. This substantial difference highlights the importance of algorithm selection and optimization in developing reliable predictive models. The higher accuracy of Light Gradient Boost algorithms suggests effective minimization of prediction errors and improved differentiation between appendicitis with periodontitis and healthy states. Our study identifies age, white blood cell count, and symptom duration as pivotal predictors for detecting concurrent periodontitis in acute appendicitis cases.

Conclusions

The newly developed prediction model introduces a novel and promising approach, providing valuable insights into distinguishing between periodontitis and acute appendicitis. These findings highlight the potential to improve diagnostic accuracy and support informed clinical decision-making in patients presenting with both conditions, offering new avenues for optimizing patient care strategies.
Falcon Neuro space-based observations of lightning using event-based sensors
Authors: McHarg Matthew G. , Jones Imogen R. , Wilcox Zachary , Balthazor Richard L. , Marcireau Alexandre , Cohen Gregory
Published: September 2024

The observation of lightning from space can have several advantages, including views of the tops of clouds, that can facilitate the study of in-cloud lightning as well as the world-wide access provided by the orbital parameters of a satellite. Given the brief duration of lightning, current space-based lighting monitors are necessarily complex in order to resolve both the spatial and temporal features of lighting discharges. Event-based sensors provide a new low-cost way of using a commercial camera to study lightning from space. The Falcon Neuro mission comprises two event-based vision sensors attached to the Columbus Module of the International Space Station. Its mission is to detect lightning and related electrical discharges in the Earth’s atmosphere. We report here on initial data collection and analysis of lightning by the United States Air Force Academy and Western Sydney University.