bluuebunny/crossref_metadata_2025 huggingface dataset:
A Time-Adaptive Space-Time FMM for the Heat Equation
Authors: Watschinger Raphael , Of Günther
Published: December 2022

We present a new time-adaptive FMM for a space-time boundary element method for the heat equation. The method extends the existing parabolic FMM by adding new operations that allow for an efficient treatment of tensor product meshes which are adaptive in time. We analyze the efficiency of the new operations and the approximation quality of the related kernel expansions and present numerical experiments that reveal the benefits of the new method.
Zeitschriften als Medienformatierung
Authors: Ehrmann Daniel
Published: December 2022

In recent years, journals have increasingly become a research topic in their own right. Trying to avoid the rigid functional definitions of journals (periodicity, publicity, etc.), it is a major challenge at the moment for literary studies to come up with a new and more appropriate way of thinking about the subject. This paper contributes to this endeavour by proposing to think about journals not as fixed items but as relational objects that not only have an impact on the texts but are affected by them as well. Thus, it suggests not to talk about journals and texts individually but to recognize the specific media formatting that they form together.
Entrechtung erfahren
Authors: Picht Barbara
Published: December 2022

Texts that bear witness to the extremes of the 20th century, from the Shoah to imprisonment in camps, to the experience of torture, or the Gulag, describe the individual experience and, at the same time, a process that points beyond one’s own fate and has something to do with the essence of law. The authors describe a concrete and fundamental sense of the legal status of an individual. Simultaneously, the legal principle is touched, violated, and destroyed, on which selfhood, and with it, an interpersonal sense of being human is based.
Winter is Coming: Screen Villages and Cold War History
Authors: Koepnick Lutz
Published: December 2022

This essay discusses the German television series Tannbach (Line of Separation) to ask new questions about the representation of village life in German cinema and television. Though set during the Cold War, the series – I argue – invites us to rethink the conventional image of the village against the backdrop of twenty-first century perspectives on borders and migration, the commodification of technologies of seeing, and the Anthropocene’s impact on so-called natural habitats.
Enrique Garcés, el portugués que tradujo a Petrarca y Camões al español
Authors: Garribba Aviva
Published: December 2022

La primera traducción completa del Canzoniere de Petrarca, tardía (Madrid 1591) y sin rivales hasta el siglo XX, es obra de Enrique Garcés, un portugués que se trasladó a Perú hacia 1525 y que, aun llevando una vida aventurera y sin ser literato de profesión, llegó a publicar también, en la misma fecha y lugar, otras dos traducciones al castellano, una de las cuales es la de Os Lusiadas. Este artículo se centra especialmente en su figura singular y en sus poemas contenidos en los paratextos de las tres traducciones.
Poetas de ida y vuelta: Jerónimo Corte-Real ante Felipe II
Authors: Martínez Torrejón José Miguel
Published: December 2022

Hacia 1585 Jerónimo Corte-Real escribe La lamentable pérdida del rey D. Sebastián y del reino de Portugal, recientemente redescubierto y publicado. Se hace una lectura del mismo como culminación de una secuencia poética desarrollada en el contexto de las relaciones diplomáticas en torno a la Jornada de África. En 1576 Corte-Real, instigado por D. Sebastián, había cantado la victoria de Lepanto en su Felicísima victoria; poco después, Francisco de Aldana dedicaría sus Octavas a Felipe II, que completaban el cuadro pintando la necesidad de esta nueva empresa contra el Gran Turco, al tiempo que Costa Perestrello conecta ambas en La batalla Ausonia.Después de Alcazarquivir, Corte-Real vuelve a poner su pluma al servicio de intereses políticos con su Lamentable pérdida, donde el llanto catártico no está reñido con la censura del rey desaparecido y sus malos consejeros, ni con la aceptación del nuevo rey y del nuevo orden político como lo mejor para el reino.
Adsorption behavior of molybdenum onto K-doped γ-Al2O3 and iron clay nanocomposite
Authors: Ararem Abderrahmane , Khechekhouche Fateh , Bensemma Nouar , Touiza Mohamed , Ghioub Fadhila
Published: December 2022

Adsorption of molybdenum was carried out on two materials; potassium doped γ-Al2O3 (KA) and bentonite iron oxide composite (BIOC) with purpose of using in production of chromatographic 99mTc generators, for KA absorbent, different ranges of potassium loadings have been considered, for BIOC solid the used weight ratio was (Bentonite/Fe = 2/1). Samples were characterized by XRD and WDXRF. Adsorption of MoxOy
z− species was carried out at pH 2.5 and 25 °C, effects of contact time and pH were studied. The Mo adsorption data onto used materials were well fitted using Freundlich and Langmuir models. Doped alumina samples showed higher adsorption capacities (∼90 mg g−1) than the usual alumina used in generator technology (∼60 mg g−1), whereas adsorption capacities of BIOC solid were in the range of (∼75 mg g−1).
Is intravenous magnesium sulphate a suitable adjuvant in postoperative pain management? – A critical and systematic review of methodology in randomized controlled trials
Authors: Puch Oernskov Mark , Gaspar Santos Sofia , Sohail Asghar Mohammad , Wildgaard Kim
Published: December 2022

A growing worldwide focus on opioid-free anaesthesia entails multimodal analgesic strategies involving non-opioids such as magnesium sulphate (MgSO4). Several systematic reviews have concluded there is beneficial analgesic effect of MgSO4 administration but do not take considerable heterogeneity among the studies into consideration. Medical literature published until June 2021 was searched in PubMed/Medline, Embase, Central and Web of Science: The final search yielded a total of 5,672 articles. We included only randomised controlled trials assessing the effect of intravenous MgSO4 on opioid consumption and acute postoperative pain when compared to either placebo or standardized analgesic treatment. The primary aim was to compare the homogeneity of essential variables and confounders. A post-hoc meta-analysis demonstrated a reduction in both postoperative morphine consumption (−6.12 mg) and pain score (−12.32 VAS points) in favour of the MgSO4-groups. Data for meta-analysis was missing from 19 studies (45%) on morphine consumption and 29 studies (69%) for pain score, the majority of which reports no effect for either morphine consumption or pain score. The calculated heterogeneity among the included studies was considerable for both outcomes; I
2=91% for morphine consumption and I
2=96% for pain score. Although we found a per se reduction in opioid consumption and pain score, methodological heterogeneity and clinical shortcomings of pre-, intra-, and post anaesthetic data precludes conclusions on clinical importance of intraoperative intravenous MgSO4. In addition, the reduction is likely less than what can be gained from using standardized analgesic treatment.
The Mogou Multidisciplinary Investigation Project: insights into the kinship and social organisation of a Bronze Age population in north-west China
Authors: Ren Xiaoying , Mao Ruilin , Chen Guoke , Allen Edward , Yu Yao , Storozum Michael , Yuan Jing , Wen Shaoqing
Published: December 2022

Excavation at Mogou, a Bronze Age cemetery containing over 1700 burials and 6000 individuals, has revealed a diverse range of multiple burials. Building on this dataset, the Mogou Multidisciplinary Investigation Project aims to explore connections between kinship, burial space and social organisation in Bronze Age north-west China.
Pituitary–gonadal hormones associated with respiratory failure in men and women hospitalized with COVID-19: an observational cohort study
Authors: Clausen Clara Lundetoft , Holm Johannsen Trine , Erik Skakkebæk Niels , Frederiksen Hanne , Ryrsø Camilla Koch , Dungu Arnold Matovu , Hegelund Maria Hein , Faurholt-Jepsen Daniel , Krogh-Madsen Rikke , Lindegaard Birgitte , Linneberg Allan , Kårhus Line Lund , Juul Anders , Benfield Thomas
Published: December 2022

Aim

To explore pituitary–gonadal hormone concentrations and assess their association with inflammation, severe respiratory failure, and mortality in hospitalized men and women with COVID-19, and compare these to hormone concentrations in hospitalized patients with bacterial community-acquired pneumonia (CAP) and influenza virus CAP and to concentrations in a reference group of healthy individuals.

Methods

Serum concentrations of testosterone, estrone sulfate, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and interleukin-6 (IL-6) were measured within 4 days of admission. Associations were assessed by logistic regression analysis in patients with COVID-19, and results were reported as odds ratio with 95% CI per two-fold reduction after adjustment for age, comorbidities, days to sample collection, and IL-6 concentrations.

Results

In total, 278 patients with COVID-19, 21 with influenza virus CAP, and 76 with bacterial CAP were included. Testosterone concentrations were suppressed in men hospitalized with COVID-19, bacterial and influenza virus CAP, and moderately suppressed in women. Reductions in testosterone (OR: 3.43 (1.14–10.30), P = 0.028) and LH (OR: 2.51 (1.28–4.92), P = 0.008) were associated with higher odds of mehanical ventilation (MV) in men with COVID-19. In women with COVID-19, reductions in LH (OR: 3.34 (1.02–10-90), P = 0.046) and FSH (OR: 2.52 (1.01–6.27), P = 0.047) were associated with higher odds of MV.

Conclusion

Low testosterone and LH concentrations were predictive of severe respiratory failure in men with COVID-19, whereas low concentrations of LH and FSH were predictive of severe respiratory failure in women with COVID-19.
Interoperabilitätsverpflichtungen für Messengerdienste – Rechtlicher Rahmen, Potenziale und praktische Herausforderungen
Authors: Sanders-Winter Andrea , Klute Florian , Baumgarten Patrick
Published: December 2022

Märkte für Messengerdienste sind aufgrund starker Netzwerkeffekte bislang von Konzentrationstendenzen geprägt. Nutzer können in der Regel wegen mangelnder Interoperabilität nicht mit Nutzern anderer Dienste kommunizieren. Als Abhilfemaßnahme sollen Interoperabilitätsverpflichtungen die Marktmacht dominanter Anbieter aufbrechen und Abhängigkeiten reduzieren, indem sie eine anbieterübergreifende Kommunikation ermöglichen. Der Beitrag liefert einen Überblick über relevante Aspekte der Diskussion rund um die Einführung solcher Verpflichtungen, indem er einen empirischen Überblick über genutzte Dienste in Deutschland bietet, die rechtlichen Rahmenbedingungen auf Basis des TKG bzw. des DMA darstellt sowie die praktischen Herausforderungen hinsichtlich der Umsetzung analysiert. In Anbetracht dieser Herausforderungen scheint in jeden Fall eine enge regulatorische Begleitung der Umsetzung von Interoperabilitätsverpflichtungen notwendig, um unerwünschte Nebeneffekte für Verbraucher, Wettbewerb und Innovation bestmöglich zu reduzieren.
Risk factors with Helicobacter pylori infection prevalence among children and adult symptomatic patients attending Ad-Lucem Obobogo hospital in the health district of Efoulan, Yaounde-Cameroun
Authors: Ngounouh Christian Taheu , Etoundi Mfegue Balbine Edwige , Madejo Caroline Talla , Ngo Likeng Julienne Louise , Nkoth Abel Fils , Teudjieu Dongmo Achille Noel , Marie Ngo Ndouga Marie Ngo Ndouga , Sandrine Tonmeu Douyong Chimène , Tchoffo Désiré , Nguwoh Philippe Salomon
Published: December 2022

Background: The burden of Helicobacter pylori infection (HPI) remains very high in sub Saharan Africa (SSA) with varying levels of prevalence among children and adults reported in different regions of the continent like Cameroon. The study was conducted to determine the prevalence of Helicobacter pilory (H. pilory) and to identify risk factors among symptomatic patients attending Ad-Lucem Obobogo Hospital. Methods: From January 18th, to March 22nd, 2021, we conducted a cross-sectional study among 142 gastritis symptomatic patients (children and adults) aged between 10 to 81years old attending Ad-Lucem Obobogo Hospital in Yaounde, Cameroon. Data were collected using well-structured questionnaire containing general characteristics of study participants and risk factors. Blood and fresh stool samples were performed for the presence of H. pylori antibody in sera, antigen in stool using qualitative rapid diagnostic tests (RDTs). The data were performed using Epi-info version 7 with P˂ 0.05 considered statistically significant. Results: The mean age was 36.42years old (standard deviation: ±14.85) and the females were more represented with 61.97% (88/142). Overall, the rate of IgG antibodies and stool antigen were detected in 66.90% (95/142), and 29.58% (42/142), respectively. The antigen prevalence (31.48% versus 28.41%) Odds Ratio (OR) =0.9 (0.46-2.05), P=0.84 and antibodies (75.92% versus 61.36%), OR=2 (0.93-4.23), P=0.07 were more detected in males than the females respectively. The antigen had the highest prevalence within range age (40-54) years (P=0.41) and antibody had the highest prevalence within range age ≥55years old (P=0.45). The multivariate analysis shows that, the risk factors such as education level and source of cooking water were statistically associated with HPI (P=0.02). Conclusion: This result shows the high prevalence of HPI among patients attending Ad-Lucem Obobogo Hospital in Yaounde. The risk factors such as education level and source of cooking water were significantly associated for this infection.
Unusual cause of duodenal bleeding, Brunnoma, managed unusually: a case report
Authors: Pujahari Aswini K
Published: December 2022

Brunnoma, is a benign tumor of duodenal wall. Usually present with anaemia. Endoscopy of stomach and duodenum gives the diagnosis. Pedunculated lesion is best managed by endoscopic snare and cautery excision. Lesion close to pylorus makes the endoscopy difficult. Hence a mini-laparotomy, and trans-gastric three port endo-luminal harmonic excision was done safely. Keyword: brunnoma, anaemia, endoluminal surgery
Omega-3 supplementation reduces oxidative stress and inflammation in the gut of obese rats
Authors: Hahn Gabriela Fernandes , Nunes Michely Lopes , Steffens Luiza , Jantsch Jeferson , Deniz Bruna Ferrary , Giovenardi Márcia , Guedes Renata Padilha , Moura Dinara Jaqueline , Porawski Marilene
Published: December 2022

Obesity is a complex metabolic disease that does not have an effective treatment. It has been demonstrated that omega-3 fatty acids are beneficial to metabolism, but little is known about their effects in the gut. This study evaluated the effects of omega-3 supplementation in metabolic and intestinal changes caused by obesity. Obesity was induced by a high fat diet (HFD) for 20weeks in 40 rats. At 16th week, the animals were divided into 4 groups: standard diet (SD); SD+omega-3; HFD; and HFD+omega-3. Omega-3 groups were supplemented with omega-3 (1g/Kg) daily, for 4weeks. Food intake, biochemical parameters in the plasma, and markers of oxidative stress and inflammation in the gut were evaluated. HFD+omega-3 group had a decrease in total cholesterol, triglycerides and LDL compared to the HFD group. In the gut, omega-3 supplementation reduced reactive oxygen species production, lipoperoxidation, superoxide dismutase and catalase activity, NFκB activation and TNFα production. These results demonstrate that omega-3 supplementation plays a beneficial role in metabolic parameters and is able to decrease oxidative stress and intestinal inflammation in obese rats. Thus, omega-3 supplementation could be a useful tool in the treatment of obesity.
Future approaches for Brucellosis vaccines and therapies development based on molecular host-pathogen interactio
Authors: Ahmed Manal ME
Published: December 2022

This review discusses Brucella-host interactions on molecular base and brucellosis immunobiological response. Also, the review handles pathogenesis-informed rationales to prevent or treat brucellosis. Brucella species is an animal pathogen that may cause incidental human brucellosis as a zoonotic disease. Brucellosis results in worldwide economic losses, human morbidity, and poverty. Despite Brucella species infect humans as an incidental host, 500,000 new human brucellosis occur annually, and no approved human vaccines or patient-friendly therapies are available. Brucella has strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that hinders its exposure to innate and adaptive immune responses, sequesters the pathogen from antibiotics effect and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion system(T4SS) dependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of DC maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of NGS of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now approved human vaccines inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent novel targets for safer and more effective brucellosis vaccines and treatment.
Indications and complications of balloon enteroscopy in Southwest of Iran: a 3years cross sectional survey
Authors: Pezhman Alavinejad Pezhman Alavinejad , Farzad Jassemi Zergani Farzad Jassemi Zergani , Tarahom Pardis , Najafi Mohammad Amin
Published: December 2022

Introduction: The advent of capsule endoscopy (CE) and balloon-assisted Enteroscopy has changed the diagnosis and management of small intestine disorders over the past decade. The purpose of this evaluation is to review the findings of small intestine evaluation by Balloon Enteroscopy in Imam Hospital of Ahvaz between 2016 and 2019. Method: The present study is a descriptive epidemiological study that has been conducted using the files in the archives of Ahvaz Imam Hospital on a cross-sectional basis between 2016 and 2019 on all of the cases referred to this tertiary center to perform balloon Enteroscopy about their indications and any potential complication. A questionnaire containing several sections designed to collect the following data. Part A: (Basic Information) including age, sex, date and type of admission. Part B: (Record of previous diseases and procedures) including general health profile. Part C: (Enteroscopy Process Findings) and Part D: any potential complication. Results: Overall 42 procedures performed (29 male (69%) and 13 female (31%). The mean age of females (41.96y) was less than males (52.16y). The most common reasons for referring for Enteroscopy was Melena with unknown source (8 cases, 19%) and abdominal pain (6 cases, 14.3%). More than half of the patients (28 cases, 67%) were nonsmoker. The most common findings of Enteroscopy include peptic ulcer disease (PUD) (12 cases, 28.6%), hemorrhage from angiectasia (11 cases, 26.2%), erosive gastritis (9 cases, 21.4%) and small bowel stenosis and atrophy (7 cases, 16.7%). Among the complications after Enteroscopy, only abdominal pain was reported (2 cases, 4.76%). Conclusion: balloon Enteroscopy is a safe procedure and useful for evaluation of source of obscure bleedings and pain of unknown origin.
The diverse ways to determine experimental dose in animals
Authors: Arya Jyoti , Bist Renu
Published: December 2022

Acute toxicity is manifested in terms of effects which occur after a single administration or a relatively brief exposure to a substance or mixture. The evidence for acute toxicity is usually obtained from animal testing so acute toxicity is usually characterised in terms of lethality and exposure times used in experimental protocols. Mainly two hazardous classes for acute toxicity are reported that are known as “Acute toxicity” and “STOT-SE (Specific Target Organ Toxicity-Single Exposure)”. This classification is based upon the evident lethality which is commonly reported as LD50/LC50 value. STOT-SE should be considered where there is clear evidence of toxicity to a specific organ, especially when it is observed in the absence of lethality. Once the LD50/LC50 value is determined, then acute toxicity estimate (ATE) could be decided therefore accurate measurement of LD50 is cardinal to understand the dose responses in animal experimentations. Current review entails a diverse method for determination of acute toxicity along with their merits and demerits. Also, it unfolds why three alternative methods i.e., fixed dose procedure (FDP), acute toxicity class (ATC) method and up and down method revealed a wide acceptance from scientific community even though the classical methods were present.
Laboratory medicine at the threshold of the new century
Authors: Terres Speziale Arturo M
Published: December 2022

The purpose of this work is to make a brief review of the impact that new technologies including automation, cybernetics, informatics, robotics, and telecommunications have had in today's society with a particular focus on the Clinical Laboratory where significant evolution has been evolving through the last two decades of the 20th Century and the first two decades of the 21st Century. Laboratory Medicine is a specialty in which multiple disciplines converge, including Clinical Chemistry and Clinical Pathology, so that nowadays the concept of Clinical Laboratory Professionals has been increasingly accepted. Given that the Medical Relevance is currently the fundamental premise, the understanding and application of the Biological Variability and its importance on the establishment of Analytical Goals is better understood and accepted day. The recognition of the suitability of the laboratory should include the human dimension and the technological dimension starting with the fulfillment of bioethics so each laboratory must have a Code of Ethics dated and signed by all personnel in which they commit themselves not to incur in conflicts of interest, always placing the patient's interest above any other.
Quality improvement program; bioethics and medical relevance for clinical laboratories
Authors: Terres Speziale Arturo M
Published: December 2022

To efficiently meet the needs of Evidence-Based Medicine, Medical Laboratory Professionals shall provide verifiable support through constantly growing activities, demonstrating expertise in multiple disciplines including medical biochemistry, cytology, haematology, immunology, endocrinology, microbiology, molecular diagnostics, genetics, and nuclear medicine. This requirement has generated increasing impact of Total Quality Management on performance. Given this situation, last decades have evolved in the three stages of the analytical process in accordance with ISO / IEC 15189 covering quality comprehensively, including ISO/IEC 17043 for Proficiency Testing Providers. In order to achieve the highest level of quality medical laboratories must work on the basis of the Code of Ethics of the Pan American Health Organization which significantly emphasizes combating “dichotomy” that shall be considered as illegitimate paybacks that inevitably harm patients and other customers. In the Latin American Association of Medical Pathology and Laboratory Medicine we are committed to continuously working with improving the quality of Latin American Medical Laboratories. Once we understood this and took on the task to provide an instrument of international standard and particularly tailored to fulfil the needs and possibilities of our region. Indeed, we proceeded to consult with members of with a proposal that was overwhelmingly accepted to carry it forward. This is how PROMECAL Quality Improvement Program was established to improve performance of Latin American Medical Laboratories. A pro bono and voluntary programs for all laboratories wishing to participate can do so without cost problems inherent in programs Accreditation and Certification. The fundamental of this program is that it provides to be treated on the basis of the principles of ethics, suitability, competence and medical relevance for what can only be carried out between pairs exclusively, i.e., only between authentic medical laboratory professionals.
Hyaluronic acid fillers in facial contouring:The “Less is More” concept
Authors: Braccini Frederic , Erfan Nouran , Fanian Ferial
Published: December 2022

Background: Aesthetic dermatology is a rapidly evolving field of medicine that allows for minimally invasive procedures, little to no recovery time and cost-effective techniques. Hyaluronic Acid (HA) fillers are used for facial contouring, the treatment of facial volume loss & enhancing the natural light reflecting areas of the face. Aims: HA fillers are safe and generally well tolerated yet using more of the product exposes the patient to an added risk of inflammation as well as higher cost. We aim to detail the “less is more” technique that limits the number of injections and maximises natural aesthetic results. The secondary aim of this study is to point out that younger patients consult for a different motive; namely the use of HA fillers for enhancing the natural light reflecting points of the face. Materials & Methods: The “less is more” technique distinguishes between static and dynamic facial planes, allowing for natural expressions, positive patient image, an artistic analysis that encompasses the entire face including untreated facial units. This study was conducted over a period of 30 months on 162 patients divided into two age groups. Results/Conclusions: The “less is more” technique for HA fillers in facial contouring optimizes natural results by selectively diminishing negative facial expressions and allowing for natural looking volume restoration. HA fillers are also effective as a durable tool for enhancing the natural light reflecting areas of the face in patients aged 20-50.
Digital Ideal Archwire Design (DIAD) in lingual orthodontics: technique update
Authors: Cardoso Randerson Menezes
Published: December 2022

The objective of this study was to describe the update of an ideal arch development protocol, through non-dental software, for cases treated with lingual orthodontics, so that the professional can develop arches that provide a pad thin enough to contain the individualization of bracket prescriptions and regularization of the lingual surface of the teeth, regardless of the shape of the arch used - individual arch, straight, mushroom, Christmas or mixed -, providing more comfortable, biological treatments with better mechanical control.
The Wernicke-Korsakoff encephalopathy: An updated review
Authors: De Reuck Jacques
Published: December 2022

Wernicke's encephalopathy is responsible for an acute neuropsychiatric syndrome that is associated with significant morbidity and mortality. It is most frequently due to alcoholism but can also be the result of chronic diseases, mainly systemic tumours, leading to thiamine deficiency. In the non-thiamine treated patients Korsakoff’s syndrome is the residual complication of the encephalopathy. The clinical diagnosis of Wernicke encephalopathy in alcoholics requires two of the following four signs: dietary deficiencies, eye signs, cerebellar dysfunction, and either disturbed mental state or mild memory impairment. These symptoms are less specific in the non-alcoholic patients. Korsakoff's syndrome is the residual condition in none thiamine treated patients. It is predominantly characterized by global amnesia, and in the more severe cases also by cognitive and behavioral dysfunction. Magnetic resonance imaging of the brain can detect the specific lesions and be helpful for the diagnosis. Treatment with 2500 mg thiamine intravenously is recommended as soon as possible.
Epidemiological and clinical features of epileptic patients in Goma, Democratic Republic of the Congo
Authors: Polepol François Maheshe , Mukuku Olivier , Chasumba Murhula Alfred , Bugeme Marcellin , Barhwamire Kabesha Théophile , Wembonyama Stanis Okitotsho , Tsongo Zacharie Kibendelwa
Published: December 2022

Introduction: Epilepsy is one of the most common neurological conditions but the majority of epileptic patients in sub-Saharan African countries do not receive appropriate treatment. In the Democratic Republic of the Congo (DRC), very few epidemiological studies have been conducted on epilepsy. The objective of this study was to describe socio-demographic characteristics, the type of epileptic seizures, and etiological factors of these seizures in a hospital cohort of epileptic patients followed at the Neuropsychiatric Hospital Center in Goma (in the DRC). Materials and methods: This was a cross-sectional study of 917 epileptic patients received in neurology consultation at the Neuropsychiatric Hospital Center in Goma (in the DRC) from January 1st, 2017 to December 31st, 2021. Results: The median age of patients was 16 years, the median age of the patients at onset of seizures was 13 years and the median time between onset of seizures and consultation was 8.0 months; 14.2% of had a family history of epilepsy. Generalized tonic-clonic seizures were the most frequent (76.7%), followed by motor focal impaired awareness seizures (5.2%) and non-motor focal aware seizures (3.6%). The etiologic factor was found in 444 (48.4%) patients and was dominated by chronic alcoholism (20.9%), neurocysticercosis (17.6%), meningitis (14.6%), malnutrition (11.3%), cerebral malaria (8.3%), and head injury (7.7%). Conclusion: This study provides an epidemiological overview of epilepsy in Goma city. The etiological factors and types of seizures will dictate the best possible treatment options.
Evaluation of the abdominal transverse muscle in individuals with low back pain: a literature review
Authors: Rocha da Silva João Rafael
Published: December 2022

Introduction: Low back pain is the leading cause of years lived with disability in the world. Despite the relevance of the subject in the literature, some authors have criticized and conducted studies without methodological criteria for the evaluation of the transverse abdominis muscle, creating a gap in knowledge and divergences in evidence-based practice. Objective: The aim of the study was to carry out a literature review, looking for studies that observed changes in the Transverse Abdominal muscle in individuals with low back pain. Methods: The following keywords were used as methodology: Low back Pain, Lumbago, Transverse Abdominal, Transversus Abdominis, Transverse Abdominals, In the following databases: Pubmed 137 studies, Web of Science 625 studies, Scopus 228 studies. Inclusion criteria: Studies that evaluated the Transverse Abdominal muscle in individuals with pain were selected for analysis of the results. Exclusion criteria: Studies that evaluated only healthy individuals, studies that addressed treatment or therapeutic intervention, studies conducted before 2016, duplications by authors, or those that did not use evaluation as methodology were excluded. Results: Finding a total of 990 studies, after elimination for duplication, 725 articles After being analyzed and selected by the inclusion and exclusion criteria, 18 studies were selected. Conclusion: The Transverse Abdominal muscle showed changes in its muscle thickness, neuromuscular activation, motor control, between healthy individuals and individuals with low back pain, being evaluated in different postures and populations. It is suggested that the evaluation of the transverse abdominal muscle should be performed in patients with low back pain, as an important dysfunctional diagnostic tool for these patients.
Patterns and outcomes of stroke thrombolysis in a tertiary care hospital in North East India
Authors: J Basumatary Lakshya , Rath Ashutosh , Bhuyan Sonali B , Bora Debanga , Mohanti Prem , Jamir Lipoktemsu , Goswami Pranjal , Sarma Brajen , Bordoloi Neil
Published: December 2022

Introduction: Intravenous thrombolysis with alteplase (tissue plasminogen activator -tPA) has been approved as the standard of care for the treatment of acute ischemic stroke (AIS) since 1995. Although there have been sporadic reports of hyperacute stroke thrombolysis coming from North-East India, a well-structured study from this resource poor area is lacking in this regard. Objective:To study the efficacy and safety of intravenous thrombolysis with tPA in AIS. Materials and methods: All patients of acute Ischemic stroke who were thrombolysed using the 4.5 hour window period, between Dec 2017 to April 2021 were enrolled and studied. We analyzed differences in age, gender, time from onset to start IVT, door to needle time (DNT), pretreatment NIHSS score, postoperative NIHSS score, and so on. They were followed up for a period of 3 months for the determination of outcome. The death rate at 90 days and incidence of SICH were used for assessment of safety. Results:A total of 30 patients were thrombolysed. 37% of patients were thrombolysed during the covid-19 pandemic. Hypertension was the most common risk factor. The mean Door to needle(DTN) time was 74.1 minutes with the shortest being 25 minutes. The mean NIHSS score at the point of hospitalization was 12.42 and after 24 hours was 9.27. In 57.69% of patients, the primary outcome (≥4 increment in NIHSS score) was achieved. 14.8% of patients suffered from adverse outcomes (death and SICH). Conclusion: This study re-affirms the safety and efficacy of IV tPA for hyperacute stroke thrombolysis in our set-up.
Epistemological analysis of educational experiences in pedagogy of memory
Authors: Sanchez Ricardo Arrubla , Espitia Camilo Saavedra
Published: December 2022

The article analyzes the academic experiences of memory pedagogy based on published bibliographic documents, identifying the different issuing agents, the theoretical affiliations and their central concepts. Through content analysis, a sample of 33 documents was integrated to understand the anamnestic-narrative horizon in education, finding that there is a greater number of experiences in historical memory, with a high level of integration in methodologies, perspectives and techniques for the academic reading of reality, but without a cognitive ontological purpose built from the rigor of history as a social science, for its overcome the epistemological problems in the subject-object relationship that mixed teaching methods produce.
Preventing Teen Pregnancies on Teratogenic Drugs by Quality Improvement and Behavioral Economics
Authors: Mruk Veronica M. , Wise Kelly A. , Driest Kyla , Oberle Edward J. , Ardoin Stacy P. , Yildirim-Toruner Cagri , Sivaraman Vidya , Stevens Jack , McGinnis Alec , Gallup James , Mitchell Brockton , Lemle Stephanie , Jones Sarah , Maher Jackie , Berlan Elise D. , Barbar-Smiley Fatima
Published: December 2022

BACKGROUND

Adolescents with chronic disease engage in sexual activity similar to their healthy peers, with generally low utilization of contraception. Adolescents with rheumatic diseases prescribed teratogenic medications may be at risk for unplanned pregnancy.

METHODS

Using structured quality improvement (QI) methods with behavior economic (BE) principles, a multidisciplinary team aimed to implement pregnancy prevention processes for females on high-risk medications. We leveraged BE-inspired interventions including improved accessibility of consents, utilizing distinctly colored consent forms, real-time reminders, peer comparison, and audit and feedback. Our primary aim was to increase the number of days between pregnancies for postmenarcheal females followed in rheumatology clinics who were taking teratogenic medications. Phase 1 focused on annual consenting of female adolescents prescribed teratogenic drugs. Phase 2 emphasized sexual history screening and pregnancy prevention planning at every clinic visit for females ≥12 years on teratogenic medications.

RESULTS

We increased the days between pregnancies for female adolescents prescribed teratogenic medications from 52 days to >900 days by using QI methodology with BE strategies. In phase 1, annual consents for postmenarcheal patients on teratogenic medications improved from 0% in 2017 to 95% in 2021. In phase 2, sexual history screening and pregnancy prevention planning at every clinic visit improved from 2% in 2019 to over 78% in 2021.

CONCLUSIONS

A multiphase, multidisciplinary QI project with integration of behavior economic strategies can improve patient and caregiver counseling to prevent unplanned pregnancies for adolescents on teratogenic medications.
A review of species of the genus Mocyta (Coleoptera, Staphylinidae) in Ukraine
Authors: Glotov S. , Hushtan K. , Koval N. , Diedus V. , Chumak M. , Chumak V.
Published: December 2022

A review of the genus Mocyta Mulsant & Rey, 1874, which is represented in Ukraine; a description of the main morphological features and diagnostic features is made, data on ecological features, seasonal activity of adults, the distribution of representatives of the genus in Ukraine and the world and the keys to identify the species are presented. The information on the distribution of species of the genus Mocyta in the territory of Ukraine has been clarified and significantly supplemented by new findings. The results can be used to address a number of theoretical issues of faunistics, zoogeography, and ecology, as well as in compiling the inventory of the fauna of the Ukrainian Carpathians, for comparative faunal research, in the analysis of species distribution, in biogeographic constructions, studies of faunogenesis, ecological monitoring and prediction of consequences of the influence of human activities on natural ecosystems of the region. The genus Mocyta is a widespread genus, which in terms of the combination of morphological and biological features belongs to the tribe Athetini Casey, 1910 of the subfamily Aleocharinae Fleming, 1821 of the family Staphylinidae Latreille, 1802. There are 26 known species in the fauna of Palearctic, 5 of which (Mocyta clientula, M. fungi fungi, M. fussi, M. orbata, M. orphana) are represented in the fauna of Ukraine. However, it is likely that there are two more species (M. amplicollis and M. negligens), identified for the surrounding areas, for which characteristics and comparative diagnoses have also been provided. This paper is a continuation of the initiated series of reviews of genera and species of the tribe Athetini of the fauna of Ukraine. Taking into account the wide geographical distribution and significant individual variability in size, colour and shape of the spermatheca of representatives of the genus, the identification of the latter presents some significant difficulties.
Impact of climate change on forest resources: Case of Quercus rotundifolia, Tetraclinis articulata, Juniperus phoenicea, J. oxycedrus, J. thurifera and Pinus halepensis
Authors: Elmalki M. , Ichen A. , Aarab M. , Mounir F. , Mderssa M. El , Oularbi Y. , Tajdi A. , Moukrim S. , Ouzzaouit L. A.
Published: December 2022

Forest resources in the Ourika watershed are subject to several anthropogenic and climatic degradation factors. As for the human factor, this degradation of forest resources is explained by the bad practices exercised by the local population expressed by the cutting of live wood, carbonization, and overgrazing. In terms of the climatic factor, the decrease in the amount of rainfall and the increase in temperature contribute to the exacerbation of the degradation of these resources. In order to better understand the evolution of plant cover in a changing climate context, this study highlights an assessment of the impact of climate change on forest dynamics based on a process-based model at the forest landscape scale which makes it possible to simulate the changes according to growth, succession, disturbances (fire, wind, insects, etc), forest management, and land use change. This analysis is based on the use of the LANDIS-II model and the PnET-succession extension. Projections of the dynamics of forest communities are made using climate projections from the Japanese global circulation model adopted by Morocco (model for interdisciplinary research on climate – earth system models) and this by adopting the two climate scenarios , representative concentration pathways 4.5 and 8.5. The results obtained highlight the spatial distribution of the ecosystems studied after 100 years with a quantitative evaluation of the total average biomass of these resources as a function of climatic disturbances. In general, the estimated total biomass will decline over the coming years under the joint effect of the climate change and the aging of forest stands, while on the other hand, the distribution of potential areas for species settlement remains independent of the effect of these climate changes.
Molecular revision of Rhagiini sensu lato (Coleoptera, Cerambycidae): Paraphyly, intricate evolution and novel taxonomy
Authors: Zamoroka A. M.
Published: December 2022

Due to classical taxonomy, the subfamily Lepturinae is divided into two large tribes Rhagiini s.l. and Lepturini s.l. However, this division is clearly artificial and does not correspond to the evolutionary relationships between the groups of genera with different morphologies that are part of these two tribes. However, there is a consensus among researchers supporting the monophyly of Lepturini s.l. while there is no such consensus for Rhagiini s.l. Over the past three decades, there have been several attempts to revise the tribe Rhagiini s.l. and divide it into smaller tribes. These attempts were somewhat successful based on larval and adult morphology. In general, eight tribes are distinguished within Rhagiini s.l. These include Teledapini, Xylosteini, Encyclopini, Oxymirini, Enoploderini, Rhamnusiini, Rhagiini and Sachalinobiini. However, the new system of Rhagiini s.l. is not always unambiguously accepted by different researchers, which causes discussions among experts. First of all, this is due to the fact that this system is only partially natural and far from fully reflects the phylogeny not only of Rhagiini s.l., but also of entire subfamily Lepturinae. In addition to the classical morphologic methods of studies, the use of the modern molecular phylogenetic methods opens up wide prospects for solving this puzzle. However, there have been very few such studies. Moreover, all of them were based on the use of only one gene. In this study, I used a general time-reversible (GTR) model of sequence evolution based on three mitochondrial (12S rRNA, 16S rRNA, COI) and two nuclear (18S rRNA, 28S rRNA) genes. My analysis yielded a well-resolved phylogenetic maximum likelihood tree, which clearly demonstrates the paraphyly of Rhagiini s.l. It consists of at least three clades representing different and distantly related evolutionary branches: 1) PaRh, 2) OSaXyR-SEP, 3) GAC. The extant Rhagiini s.l. are mostly heterogeneous relict groups with an intricate evolutionary and phylogeographic history. Most of these groups are represented by one or very few species, often isolated geographically on different continents. In particular, numerous cases of parallel and convergent evolution and homoplasy, a chimeric combination of plesiomorphic and apomorphic morphological characters, were found in all clades. Therefore, the evolutionary "tree" of Rhagiini s.l. is more like a "bush" with numerous relict branches. Finally, I proposed a new taxonomic model of Rhagiini s.l., which is the most consistent with their natural phylogeny, with new developments in nomenclature.
Dominant landscape characteristics of the arable land red line in Donggang, China
Authors: Qian Fengkui , Wang Weiwen , Zhang Xuefeng , Zhang Jingye , Bian Zhenxing
Published: December 2022

In the face of endless idle and even abandoned farmland, it is trying to protect farmland resources and ensure food supply by determining the bottom line (red line) of arable land that cannot be changed in use. The red line has landscape characteristics and functions, but there remain limited understandings of how to judge the dominant landscape characteristics of cultivated land. Therefore, this study divides landscape characteristics into aesthetic value and stability according to landscape pattern. A comprehensive evaluation system was developed to explore the dominant landscape features of the cultivated resources based on a multi-factor comprehensive evaluation. On this basis, this study conducts an empirical study in Donggang, a coastal city in China. The results show that cultivated land resources with high aesthetic value are distributed near cities, major roads, and important natural resources. The cultivated land resources with greater continuity and compatibility with adjacent plots are relatively stable, mainly paddy fields. The red line of cultivated land should focus on the characteristics of cultivated land stability. At the same time, the aesthetic value of cultivated land resources is also an important factor (related degree is 0.852). According to this evaluation system, the dominant area of arable land protection in Donggang City is 88,027.21hm2, which is the preferred area for the red line of arable land.
The impact of EMU integration on GDP and productivity in the Baltic countries
Authors: Muchová Eva , Šuláková Agáta
Published: December 2022

We examined the effect of the accession to the Eurozone using the method of synthetic control groups. This method enabled us to compare the performance of the Estonian, Lithuanian, and Latvian economies with a combination of countries that have not accessed the Eurozone yet. We constructed a synthetic Estonia, Lithuania, and Latvia model as synthetic control units from a donor pool to evaluate the impact of the Economic and Monetary Union (EMU) on macroeconomic performance through synthetic control groups. The donor pool in our model consisted of European countries that do not use the euro. We used annual data from 1990 to 2019 for models with GDP and productivity. The results indicate that deciding to enter the Eurozone could increase productivity – measured as GDP over employment. Or in other words - if these Baltic countries did not join the euro, their GDP per employer would be lower than the actual. Accession to the Eurozone or ERM II has not increased or decreased GDP in Baltic countries as much as productivity.
Prospects and threats for developing organic agriculture: The example of Azerbaijan
Authors: Aliyev Shafa Tiflis , Mammadova Elnura Bunyad , Hamidova Lala Adil , Dunyamaliyeva Vafa Rashid , Hurshudov Shahin Nadir
Published: December 2022

The article's purpose is to evaluate empirical evidence of the main threats to organic agriculture formation and provide the argumentation of its development prospects in Azerbaijan's current conditions. Questioning of agricultural business owners identified threats and prospects for developing organic agriculture in Azerbaijan. The opportunities and threats for developing organic agriculture are determined and differentiated by groups of entrepreneurs doing business in traditional/organic agriculture. Based on the results of the clustering of the agricultural enterprises depending on the level, the priority of threats, and prospects for development, the strategies for developing organic agriculture in Azerbaijan have been determined:  educational strategy of financial accessibility, innovative growth, and infrastructure development.