bluuebunny/crossref_metadata_2025 huggingface dataset:
Doubts and risks resulting from the cooperation of communes within the institution of an inter-communal agreement
Authors: Perz Adrian
Published: February 2024

The article discusses the commencement of cooperation by communes in the form of intercommunal agreements, which in principle allow to optimize the implementation of statutory obligations related to the performance of specific public tasks by communes. Due to the rudimentary nature of regulations, both the doctrine and jurisprudence, there are many doubts related to the qualification of these agreements as institutions of civil or administrative law, including whether they are acts of local law. This results in risk on many levels, ranging from their correct announcement, through the pursuit of claims, to the end of their legal existence. This institution is a promising form that allows municipalities to perform their tasks based on the best effect mechanism by establishing cooperation between municipalities achieving results in the implementation of specific public tasks. In practice, it is not particularly popular due to a number of doubts and risks arising from the residual statutory regulations.
Correlation between Static and Dynamic Young’s Modulus of Elasticity of Different Types of Rocks
Authors: Panchal Sandeep , Ronghe Sayali S. , Lokhande Ritesh D.
Published: February 2024

Correlation between static and dynamic elastic modulus in rocks has often been addressed in various studies. In this study, the correlation between the static and dynamic elastic modulus of six different sedimentary, metamorphic and igneous rock types namely coarse-grained sandstone, fine-grained sandstone, schist, quartzite, basalt and granite are studied. Physical properties such as bulk density and porosity are evaluated of all samples. Static elastic modulus is determined by uniaxial compression test and dynamic elastic modulus is found out by ultrasonic pulse velocity testing. Scanning Electron Microscope experiment, X-Ray Diffraction experiment are also conducted on all the samples for mineralogical and petrological studies. The individual correlation between the static and dynamic elastic modulus of all the rock types have been proposed using linear regression with zero intercept and high values of coefficient of determination. These equations are useful in calculating the static elastic modulus using non-destructive techniques, in a wide range of rock materials. Finally, a general linear equation has been developed to relate ratio of static and dynamic elastic modulus with density of the rock.
A study of safety and efficacy of vitamin D3 supplementation in pregnancy
Authors: Mirza Huma Afzal , Arzoo Nigare , Prajapati Pooja
Published: February 2024

Background: Vitamin D is a lipid-soluble prohormone that is vital for the maintenance of bone and muscle health. Vitamin D deficiency is an unrecognized epidemic, common in all age groups and is associated with preeclampsia, gestational diabetes, preterm birth, early labour and pregnancy loss.
Methods: Our study was conducted in Batra hospital and medical research centre, New Delhi from October 2018 to May2019. 126 women were taken, of those seen before 20 weeks of pregnancy who received vitamin D3 supplementation comprised of study group and control group were those who came directly for delivery and without vitamin D3 level done. The outcomes measured were vitamin D3 level at 20 weeks, at delivery, in cord blood and clinical outcomes like pre-eclampsia, gestational diabetes, preterm delivery.
Results: Gestational hypertension was seen in 4 (6.3%) of subjects while in control group it was seen in 11 (17.5%), Gestational diabetes was seen in 3 (4.8%) women while it was observed in 10 (15.9%) women of control group. Premature rupture of membranes was seen in 2 (3.2%) women in study group and 8 (12.7%) women of control group. Vitamin D level at the time of delivery in study group was significantly higher than control group (56.84±15.78 versus 18.12±8.97ng/ml).
Conclusions: Preterm labor, low birth weight and preeclampsia were uncommon in the subjects and the administered vitamin D3 dose had no adverse effects but more research with larger sample size is strongly urged to assess the safety and effect of vitamin D3 supplementation.
Expert opinion on the prescription practice of silodosin for treating benign prostatic hyperplasia patients in Indian clinical settings
Authors: S. Manjula , Kumar M. Krishna
Published: February 2024

Background: The effectiveness and safety of silodosin compared to other drugs have been the subject of numerous studies to date, although the findings are debatable. So, this study aims to gather expert opinion on the prescription practice of silodosin for men with lower urinary tract symptoms leading to benign prostatic hyperplasia.
Methods: This cross-sectional, multiple-response questionnaire-based survey, included experts from various states across India with expertise in treating BPH. The study questionnaire, comprising 25 survey items on the management of BPH utilizing silodosin (8 mg) and other drug combinations to gather data via email or an online survey platform.
Results: Out of the 55 experts, 76% identified non-specific urinary tract infections as the most prevalent concomitant ailment in BPH patients. The majority of the experts (89.09%) recommended silodosin medication for these patients, and about 58% reported that patients might need to continue silodosin medication for three months. Another major benefit reported was its high selectivity for alpha 1A receptors (34.55%). However, 47% of experts reported retrograde ejaculation as a side effect, and 27% reported orthostatic hypotension. According to nearly 80% of responders, patients with BPH can use silodosin in combination with mirabegron (25/50 mg). A combination of silodosin and dutasteride was favoured by 67% of responders for BPH patients with acute urine retention.
Conclusions: The expert consensus has highlighted silodosin as an effective treatment option for LUTS in men with BPH in Indian settings. Silodosin and dutasteride combination were recommended by specialists for BPH patients with acute urine retention.
A case of tuberculous peritonitis accompanied by tuberculous pleuritis
Authors: A. Wahyu Larasati , Y. Dwiputra Pramarta
Published: February 2024

Tuberculous peritonitis is a form of extrapulmonary tuberculosis, a peritoneal or visceral inflammation caused by Mycobacterium tuberculosis. The disease is rarely independent, but is usually a continuation of the tuberculosis process elsewhere, especially pulmonary tuberculosis. We report a case of TB peritonitis accompanied by TB pleurisy, a 29-year-old female patient with complaints of an enlarged abdomen, heartburn, fever, diarrhea, and decreased appetite. Treatment history was Acitral, Zinc, and Metronidazole. On physical examination, it was found that the general condition was weak and the axilla temperature was 39.5ºC. Thorax examination; decreased vesicular sound on the left chest. Abdominal examination; found distension, epigastric tenderness, undulation, shifting dullness, checkerboard phenomenon, and increased bowel noise. Laboratory examination of complete blood; within normal limits. Complete stool; yellow color, mucus (+), leukocytes 4-6/LPB, bacteria (+). The thorax photo showed left pleural effusion, BOF 3 position: ascites. Abdominal ultrasound results: thickening of the peritoneum, ascites, suspected TB peritonitis. Results of ascites and pleural fluid analysis: rivalta (+) and Adenosine Deaminase (ADA) increased. So that from anamnesis, physical examination, supporting examination can be established diagnosis of TB Peritonitis and TB Pleuritis, followed by OAT therapy; FDC for 12 months. From this case it can be concluded that clinical and supporting examinations (radiology) are needed to make a correct diagnosis and body fluid analysis examinations can help confirm the diagnosis.
STRATEGI BIMBINGAN DAN KONSELING ISLAM DALAM MENINGKATKAN MINAT ANAK UNTUK MEMBACA AL-QUR’AN DI TK/TPA UNIT 134 AL-ITTIHAD DI KOMPLEK WAY HITAM PAKJO PALEMBANG
Authors: Razzaq Abdur , Meilani Methy
Published: February 2024

Penelitian ini bertujuan untuk mengetahui minat anak, dan strategi guru dalam mengajar, serta penggunaan strategi bimbingan dan konseling dalam meningkatkan minat anak dalam membaca al-Qur’an. Penelitian ini termasuk jenis penelitian lapangan (Field research) yang bersifat kualitatif. Teknik pengumpulan data dengan menggunakan observasi, wawancara, dan dokumentasi. metode analisis data yaitu melalui empat tahap yaitu: reduksi data, penyajian data, penarikan kesimpulan. Dari hasil penelitian Minat membaca Al-Qur’an anak di TK/TPA unit 134 Al-Ittihad komplek Way Hitam Pakjo Palembang rata-rata minatnya cukup bagus dapat dilihat dari pengajaran guru serta motivasi dari orang tuanya, ada yang mewajibkan untuk menggulangi di rumah dan ada yang tidak ini di lihat dari sisi motivasi orang tuanya. Sedang dari gurunya dia hanya mengajari dan memberikan contoh kepada santri bagaimana cara mengaji yang benar, mengajari tajwid serta panjang pendek bacaan tersebut. Strategi bimbingan dan konseling dalam meningkatkan minat anak untuk membaca al-Qur’an di TK/TPA unit 134 Al-Ittihad komplek Way Hitam Pakjo Palembang, dapat kita lihat dari guru dan orang tuanya. Disini guru dan orang tuanya bekerja sama dalam hal membimbing dan mengajari anak-anaknya di rumah, di TK/TPA guru mengajari dan mencontohkan bacaan al-Qur’an yang benar, sedangkan dirumah orang tua menyuruh untuk mengulangi membaca al-Qur’an yang telah di ajarkan oleh gurunya.
Efektivitas Konseling Individual Menggunakan Teknik Brainstorming untuk Meningkatkan Komunikasi Interpersonal
Authors: Bulantika Siti Zahra , Kushendar Kushendar , Sa'adah Hj
Published: February 2024

Tujuan dari penelitian ini adalah untuk melihat keefektifan konseling individu menggunakan teknik brainstorming untuk meningkatkan komunikasi interpersonal siswa di MTS N 1 Bandar Lampung. Jenis penelitian ini adalah penelitian subjek tunggal atau disebut Single Subject Research (SSR) pada subjek siswa kelas VIII di MTS N 1 Bandar Lampung. Desain penelitian A1-B-A2 menggunakan instrumen GAS (Goal Attainment Scaling) yang terdiri dari beberapa skala GAS, yaitu self-efficacy, partisipasi di depan kelas, keterbukaan, reaksi spontan, dan kejujuran. Hasil penelitian menunjukkan peningkatan yang signifikan dalam komunikasi interpersonal melalui teknik brainstorming di baseline A1, intervensi, dan baseline A2.
Peningkatan Sifat Malu (Al-Haya’) Pada Mahasiswa Melalui Layanan Bimbingan Kelompok Berbasis Hadits
Authors: Jannati Zhila
Published: February 2024

In its journey, disobedience and goodness are choices for humans. The difference is, someone who has a shy nature (al-haya') will firmly choose goodness for his life. Because, he fears his Lord and will do something that is only in accordance with what Allah swt has. commanded and will abstain from all that He forbids. This is a high level of shame that actually must be embedded in humans, namely shame because they feel close to Allah swt so that they are able to witness the presence of Allah swt. The purpose of this study was to find out how to increase shyness (al-haya') in students through hadith-based group guidance services. The research method that researchers use is descriptive research method. Data collection techniques used are observation and interview techniques. While the researchers took the subject of the students of the Faculty of Da'wah and Communications at UIN Raden Fatah Palembang. The data analysis technique uses three stages, namely reduction, data display and conclusion drawing (verification). This study obtained results, namely (a) hadith-based group guidance has been carried out by passing through four stages, namely the formation stage, transition stage, activity stage, and termination stage, and (b) the student's shyness has increased where his soul has been controlled and he has felt not happy, uncomfortable, and depressed when doing things that are forbidden by Allah swt. (bad deeds or immorality), as well as a desire to leave or stay away from bad things carefully.
Guidance and Counseling Implementation Through the Parenting Program in the Early Childhood Education Unit
Authors: Yusuf Muhammad
Published: February 2024

Management Guidance and counseling for children's education can be done with various methods and approaches. One of the objectives of this research is to provide an overview of the implementation of guidance and counseling through parenting programs in schools. The parenting program in schools is a manifestation of the collaboration between teachers and parents in providing stimulus to children's development. The type of this research is field research with a descriptive qualitative approach. As for the data collection through observation with the manager. Furthermore, conducting interviews with teachers with parenting mentors, and documentation. Related to the results of research on guidance and counseling services by kindergarten managers, it illustrates that the parenting program held has a great impact on teacher competence, child development, as well as building ghiro to improve the quality of learning and the cooperation of parents and guardians of students.
Efektivitas Penggunaan Model Window Shopping untuk Meningkatkan Minat Siswa Mengikuti Layanan Bimbingan dan Konseling
Authors: Thalib Muh. Mansyur , Wahyuningsih Nur Eka , Fitriani Dian , Nurwahyuni Nurwahyuni , Hasan Hasan
Published: February 2024

The main objective of this research is to increase students' interest in following the guidance service by using the window shopping model in classical guidance services. The type of research used is quasi-experimental. The number of subjects in this study was 29 students. Data collection was carried out using a questionnaire. The data collected was then analyzed descriptively and inferentially. The results showed that before the window shopping model was used, students' interest in participating in the guidance service varied from not interested to interested. Still, the most dominant classification was less interested and not interested. After using the window shopping model, students' interest in participating in classical guidance services also varied, but the most dominant was the classification of moderately interested and interested. This study's results indicate an increase in students' interest in following classical guidance services. Therefore, it can be concluded that the use of the window shopping model in implementing guidance services effectively increases student interest in participating in guidance services. The results of this study imply that school counselors can follow up using a window shopping model in implementing classical guidance services. School counselors can also use this model in guidance and counseling action research as an effort for continuous professional development.
Konseling Kelompok Melalui Tari Sambut dalam Meminimalisir Kecanduan Game Online pada Anak Sanggar Tari Seruni Palembang
Authors: Darmawani Evia , Laksana Robert Budi , Dedy Adrianus
Published: February 2024

The problems started covid while 19 have gone as well as learning during the learning offline, but affects the school age children including dancer seruni houses in palembang, usually school age children ranging from ( paud ) kanak-kanak park, primary school and secondary school first is cradled and berleha-leha by playing online games; mobile legend, free fore, school pubg mobile and neglect of duty, time interacting with keluarg, peer and other environmental. Conducted by penelitiuntukmembantupenari sehinggadiperlukansatuintervensi school aged by providing counseling groups through dance to welcome in minimize addicted to gaming houses onlline in palembang call seruni dance.This study attempts to attain further information about counseling group with a dancer in helping konseli tarisambut ( ) oneline addicted to break away from the game, besides mengenaliciri addicted to game oneline on dancer in a shrine seruni palembangpenelitiandilakukan seruni palembang dance in a shrine to the population and a dancer who trained dance to welcome were the; 10 6 4 the junior high school aged children and the primary school.Therefore, a intervention taken by the researchers to help the dancer in school age by providing group counseling through welcome dance in minimizing game addiction on lline on the balloon dance ring.The study aims to obtain further information about group counseling with welcome movements in helping counsel (dancer) get rid of online gam.Techniques of collecting observation and interview data (qualitative data) and scores of observation and interview results.Data analysis transforms qualitative assessments into quantitative. then calculate the average value of each aspect with the percentage formula, Interpretation of equal value qualitatively.Research results show that there are behavioral changes in children after performing dance therapy to cope with online gaming addiction.Children become more active and productive in dance activities and beneficial activities both at school and outside school in everyday life.Keywords: group counseling, addiction game on line, Dancing childrene addiction. In addition to analyzing online game addiction on the dancer in the seruni plays.The researchers performed in the balloon dance hall with a population and sample of dancer trained welcoming dancer trained in a total of 10 people; 6 children of the age of SMP and 4 people sd.Combined quantitative and quantitative research types with research and development approach
Isu Kesehatan Mental Pasangan Suami Istri yang Belum Memiliki Keturunan di Usia Pernikahan di Atas 5 Tahun
Authors: Handayani Eka Sri
Published: February 2024

One of the social expectations and demands that couples must face is that they must have children, at least in the first year after marriage. This is based on the statement of a woman who has never been pregnant and has not had children after several years of marriage. These demands greatly affect the status of women in society. This suggests that if a woman is unable to bear children, her social status is considered lower than women who have children. This shows the magnitude of social demands that must be faced by women who do not have children. Marital unhappiness can also be seen in further inability to adapt, for example the development of psychosomatic illnesses, depression, anxiety, infidelity, alcoholism, cruel treatment of children. The data collection method in this research uses interview, observation and documentation methods. After obtaining the data, it is analyzed descriptively qualitatively, because descriptive research is very simple, namely just asking or collecting information and reporting the results. Descriptive research is research into the status, attitudes, opinions of groups of individuals, sets of conditions and procedures, a system of thoughts or events in order to create a systematic and analytical description.
Studi Kasus Kestabilan Emosi Mahasiswa Yang Menikah Pada Masa Perkuliahan
Authors: Putriana Haryani , Mz Ihsan , Erawati Desi
Published: February 2024

This study aimed to observe the description of the emotional stability of IAIN Palangka Raya students who were married, considering the two roles that were brought simultaneously. Focusing on aspects of emotional stability, namely, emotional adequacy, emotional maturity, and emotional control. This type of qualitative research, with data collection techniques using interviews and observation. Data analysis using  the NVivo application. The research informants consisted of four pairs of husband and wife, eight people with the characteristics of students who were married and actively attend lectures. The results showed that  emotional stability of married IAIN Palangka Raya students in terms of the emotional adequacy aspect was owned by four couples, as evidenced by a sudden change in circumstances. Emotional control, found in all four pairs, was based on the response that arised to emotional impulse. Furthermore, emotional maturity appears in two pairs, one of the two was experienced only by husbands and wives from couples who were not included in the emotional maturity aspect.
Zachęta do tłumaczenia na język polski dzieła polihistora Gabriela Rzączyńskiego pt. „Historia naturalis curiosa Regni Poloniæ, Magni Ducatus Lituaniæ, annexarumque provinciarum, in tractatus XX divisa” z 1721 roku
Authors: Skoczylas Michał M.
Published: February 2024

Gabriel Rzączyński’s Historia naturalis curiosa, composed of twenty treatises, published in 1721 in Sandomierz, has been a source of information about the Polish–Lithuanian Commonwealth (Res Publica Utriusque Nationis) for many years, and one of the most extensive attempts to characterize the natural environment of the country. It also contains information on historical events that involved the natural world and the state of knowledge and medical practice in Poland and Lithuania. Historia has also been the subject of many secondary studies and historiographical analyses, but has not yet been translated into its author’s native language. A concise description of its content and a discussion of its importance for academic reflection are intended as an encouragement to translate the opus into the languages of the nationalities that formed the state at that time.
„Jeśli jeszcze tylko zabijemy starca...” Farsa kryminalna w teatrze grecko-rzymskim w Egipcie (POxy. 413 verso)
Authors: Kotlińska-Toma Agnieszka
Published: February 2024

This paper presents a translatory proposition of the mime preserved on POxy. 413 verso (Moicheutria) into Polish, along with a concise analysis of the theatrical and literary issues that are observed in this ancient genre.
Controlling the output current of a SEPIC H-bridge inverter
Authors: Wisnu Mahendra Roy Fada Krisna , Pratomo Leonardus Heru
Published: February 2024

The rapid depletion of fossil fuels and humanity's increasing dependence on electricity drive us to adopt renewable energy-based power generation. However, using renewable energy requires a system to maximize the results of converting renewable energy into electrical energy. An inverter is a DC-to-AC power conversion device. Inverters have two types: buck and boost. In closed-loop control, it can be controlled using current or voltage control. Current-controlled inverters sent to the grid have constraints, such as the inverter input voltage value must exceed the voltage on the grid. This study suggests using an H-bridge inverter and an AC-AC SEPIC to generate a voltage value more significant than the input voltage value. The proposed converter uses a single DC source and bases grid current injection on the regulated output current approach. The proposed converter satisfies the IEEE Std 519-2014 requirement of less than 5% and has a Total Harmonic Distortion (THD) of 4.6%.
Cloud-based Metabase GIS Data Analysis Platform Quality Management According to ISO 9126 Indicators
Authors: Purbaningtyas Rani , Widianta Moh Munih Dian , Albaab Mochammad Rifki Ulil
Published: February 2024

Platform metabase GIS data analysis based on the cloud that has been successfully developed is an alternative solution for spatial-text data analysis. The output of this cloud-based platform not only provides accurate textual information but also precise location representation of the objects. This research examines the quality of the developed platform based on ISO 9126, which consists of six main indicators: functionality, reliability, feasibility, efficiency, maintainability, and portability. Each indicator has different sub-indicators, totaling 22 sub-indicators. The quality assessment results indicate that the platform for metabase GIS data analysis based on the cloud exhibits excellent quality, with an average test result based on the ISO 9126 indicators reaching 93%.
Strunck, Britain and the Continent 1660-1727: Political Crisis and Conflict Resolution in the Paintings at Windsor, Chelsea, Chatsworth, Hampton Court and Greenwich (Berlin: De Gruyter, 2021)
Authors: Koscak Stephanie
Published: February 2024

Review of Britain and the Continent 1660-1727: Political Crisis and Conflict Resolution in Mural Paintings at Windsor, Chelsea, Chatsworth, Hampton Court and Greenwich. By Christina Strunck. Berlin: De Gruyter, 2021. ISBN 978-3110729610 527 pp. €99.95.
Russo, The Afterlife of Anne Boleyn: Representations of Anne Boleyn in Fiction and on the Screen (Cham: Palgrave Macmillan, 2020)
Authors: Brouet Aurore
Published: February 2024

Review of: Stephanie Russo, The Afterlife of Anne Boleyn: Representations of Anne Boleyn in Fiction and on the Screen ( Cham: Palgrave Macmillan, 2020)
Haarer, Justinian: Empire and Society in the Sixth Century (Edinburgh: Edinburgh University Press, 2022)
Authors: White David Lloyd
Published: February 2024

Review of: Justinian: Empire and Society in the Sixth Century. Debates and Documents in Ancient History Series. By F.K. Haarer. Edinburgh University Press, 2022. ISBN 978-0-7486-3979-2 (web-ready PDF). vi + 257 pp. £95.
The Houses of the Princesses Joanna, Isabel, and Violant (1375-1392): Formation, Composition, and Characteristics of Minor Curial Areas
Authors: Cingolani Stefano Maria
Published: February 2024

The purpose of this study is to examine for the first time the formation, composition, and functioning of the houses of three unmarried princesses (infantas) of late fourteenth-century Spain; to consider the purposes of the houses and situate them within the complex galaxy of households belonging to kings and princes of the time; and, finally, to propose some subjects worthy of further investigation.
THE MICROBIAL “FINGERPRINTS” FROM THE CONTINENTAL LOWER PERMIAN OF POLAND
Authors: SADLOK GRZEGORZ
Published: February 2024

Microbes colonize sediment and alter its properties creating a bio-mineral medium. The microbially induced sedimentary structures (MISS) are the fossil record of an interaction between the physical environment and such a medium. The present report documents bedding surface structures from the Cisuralian (Asselian) Sandstone Building Member (BSM) of the Słupiec Formation, a unit that outcrops in the south-western Poland, in the Sudetes Mountains. The BSM represents likely continental (fluvial) sedimentary settings. The sedimentary structures on bedding surfaces in the BSM are interpreted as the MISS. The observations of the bedding structures are supplemented with thin section data that support the microbial interpretation of the bedding surface structures. The Słupiec Formation MISS record supplements the global patchy fossil record of the post-Cambrian (Paleozoic) MISS from the non-marine settings.
Fabrication, characterization, and testing of a sharp cutting-edge radius sapphire tool for ultra-precision machining
Authors: Dodmani Amit , Subbiah Sathyan , Kumar A. Senthil
Published: February 2024

Achieving a smooth surface finish in optical components by machining requires wear resistant sharp cutting tools. Single crystal diamond as a cutting tool material has met this requirement so far, but at a cost disadvantage. An economical alternative, such as alumina single crystal(sapphire), with sufficient hardness, wear resistance, and chemical inertness, is explored in this work. A sapphire cutting tool with a zero rake, seven-degree clearance, and edge radius of about 430 nm is fabricated using lapping, polishing, and chemical mechanical polishing processes. The performance of the tool was evaluated via orthogonal cutting of OFHC copper, free-cutting brass, Al6061, and Stavax ESR steel. The influence of parameters, such as cutting speed and uncut chip thickness, on surface finish, cutting force, thrust force, friction coefficient, and chip morphology are analyzed. It was observed that the sapphire tool generates surfaces with average roughness ranging from 10–40 nm on copper and aluminum alloys. However, minimal tool wear observed in the machining of copper alloys and excessive in the aluminum alloy and Stavax. Furthermore, built-up edge was significant in Al6061, and edge chipping was dominant in Stavax during machining. Sapphire is a suitable alternative cutting tool material for machining copper alloys.
A Prospective Study of Sleep Quality in Women Undergoing Chemotherapy for Breast, Ovarian, and Endometrial Cancer
Authors: Cantillo Evelyn , Sharkey Katherine , Luis Christine , Raker Christina , Robison Katina
Published: February 2024

Purpose
To describe changes and assess associations in sleep quality and quality of life (QOL) among chemotherapy naïve women undergoing treatment for breast, ovarian, or endometrial cancer
Methods
A prospective cohort study was performed in a Women’s Oncology Program. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and QOL using the Functional Assessment of Cancer Therapy (FACT) prior to-, halfway through-, at completion of-, and 6 months after chemotherapy. Patients with ovarian and endometrial cancers were combined into one group (GynCa) for analysis. The PSQI and FACT scores were analyzed using multivariable linear and logistic regression.
Results
Of the 102 eligible patients, 97 participants enrolled: breast (n=47), ovarian (n=27), and endometrial (n=23). Prior to starting chemotherapy, 59% of women reported poor sleep quality. By mid-treatment, both groups experienced worsening sleep quality: breast (p=.05) and GynCa (p=.04), and QOL: breast (p=0.0001) and GynCa (p=0.02). Changes in sleep quality did not persist at treatment completion. A significant QOL improvement was reported among GynCa patients compared to the breast cohort at 6-months post-treatment (p=0.047). Poorer sleep quality was associated with lower QOL at most study time points.
Conclusions
The majority of chemotherapy naïve women reported poor sleep at baseline. By treatment completion, average PSQI scores continued to show clinically significant sleep disturbances. Poor sleep quality is associated with lower QOL, a prognostic indicator for survival. Future work should examine whether disturbed sleep during chemotherapy worsens treatment outcomes. Poor sleep may be a novel therapeutic target in this population
Feasibility of a Restrictive Transfusion Strategy for Patients Undergoing Malignant Tumour Resection: A Multicentre Prospective Observational Study
Authors: Yu Xiaochu , Chen Yali , Wang Lei , Huang Yuguang , Wang Yipeng , Liu Zhong , Xin Shijie , Lei Guanghua , Yu Xuerong , Wang Zixing , Zhao Jing , Chen Wangyue , Yang Cuihong , Jiang Jingmei
Published: February 2024

Background
The recommended transfusion threshold for surgical oncology patients remains unclear owing to insufficient evidence from randomized controlled trials. Evidence from observational studies has been questioned because of huge patient heterogeneity. We aimed to assess the safety of restrictive transfusion at a minimum tolerable haemoglobin threshold for surgical oncology patients with observational data using a tailored design and analysis.
Methods
Data were collected from four representative regional hospitals in China during 2015 − 2016. Surgical inpatients with seven types of cancer (total cancers) comprised 6055 participants as the base population. In our design, we (1) derived a primary analytic sample by the interested zone of transfusion decision: 6–10 g/dL; (2) selected the control group according to trigger haemoglobin threshold; (3) evaluated the patient heterogeneity between the transfused and non-transfused groups with key covariates according to standardized mean difference (SMD) values. Analysis is mainly based on two datasets: The base population to obtain a natural pattern of transfusion practice; and the primary analytic sample to evaluate the safety of a restrictive transfusion strategy.
Results
In the base population, 836 (13.81%) were transfused and showed high heterogeneity compared with non-transfused patients (SMD: 7.1–71.31%); there was a significant positive association between transfusion and the composite outcome (in-hospital complications and death) (P < 0.05). In the primary analytic sample, patient heterogeneity was greatly reduced (all SMD ≤ 10%). Compared with non-transfusion, transfusion no longer increased the risk of the composite outcome for total cancers at haemoglobin 6–10 g/dL (odds ratio [OR]: 1.18, 95% confidence interval [CI]: 0.71–1.98), especially for colorectal cancer at 6 − 8 g/dL (OR: 0.54, 95% CI: 0.17–1.68). Compared with those transfused at haemoglobin 8–10 g/dL, patients transfused at 6–8 g/dL did not increase the risk of the composite outcome for total cancers (OR: 1.08, 95% CI: 0.44–2.65), especially for colorectal cancer (OR: 0.46, 95% CI: 0.12–1.82).
Conclusions
A restrictive transfusion threshold of 8 g/dL may be feasible for total cancers, with a threshold as low as 6 g/dL for colorectal cancer. Restrictive transfusion evidence can be complemented with observational data using a tailored design and analysis.
A Frequency Domain Adversarial Attack in Medical Image Analysis System
Authors: Guan Xiaohui , Chen Guoxiang , He Shuke , Sun Xinxin , Qian Yaguan
Published: February 2024

Deep neural networks (CNNs) have gained popularity in medical image analysis tasks, such as cancer diagnosis and lesion detection. However, recent research has revealed that medical deep learning systems are vulnerable to adversarial examples. In this paper, We propose a novel attack method from a spatial-domain perspective, named TextureDrop. The method crafts adversarial examples by dropping the high-frequency components (HFC) of medical images, thus making the medical image classification model misclassified. Additionally, we have developed a training method for medical neural networks. Extensive experiments have demonstrated the effectiveness of our method, which is not only more destructive but also stealthy. Furthermore, our approach introduces a new assessment framework for evaluating the robustness of medical networks from a frequency-domain perspective.
Cardioprotective effects of vaccination in hospitalized patients with COVID-19
Authors: Madrid Julian , Agarwal Prerana , Müller-Peltzer Katharina , Benning Leo , Selig Mischa , Rolauffs Bernd , Diehl Philipp , Kalbhenn Johannes , Trummer Georg , Utzolino Stefan , Wengenmayer Tobias , Busch Hans-Jörg , Stolz Daiana , Rieg Siegbert , Panning Marcus , Bamberg Fabian , Schlett Christopher L. , Askani Esther
Published: February 2024

Background
COVID-19 vaccination has been shown to prevent and reduce the severity of COVID-19 disease.
Aim
The aim of this study was to explore the cardioprotective effect of COVID-19 vaccination in hospitalized COVID-19 patients.
Methods
In this retrospective, single-center cohort study, we included hospitalized COVID-19 patients with confirmed vaccination status from July 2021 to February 2022. We assessed outcomes such as acute cardiac events and cardiac biomarker levels through clinical and laboratory data.
Results
Our analysis covered 167 patients (69% male, mean age 58 years, 42% being fully vaccinated). After adjustment for confounders, vaccinated hospitalized COVID-19 patients displayed a reduced relative risk for acute cardiac events (RR: 0.33, 95% CI [0.07; 0.75]) and showed diminished troponin T levels (Cohen’s d: -0.52, 95% CI [-1.01; -0.14]), compared to their non-vaccinated peers. Type 2 diabetes (OR: 2.99, 95% CI [1.22; 7.35]) and existing cardiac diseases (OR: 4.31, 95% CI [1.83; 10.74]) were identified as significant risk factors for the emergence of acute cardiac events.
Conclusion
Our findings suggest that COVID-19 vaccination may confer both direct and indirect cardioprotective effects in hospitalized COVID-19 patients.
Radiographic Evaluation of Tuberculosis: a retrospective study among patients in Al- Mouwasat hospital in Damascus
Authors: Al-moalem Mohamad , Al-askar Abdulaziz , Mahmod Jan , Khattab Khalid
Published: February 2024

Background
Tuberculosis (TB) presents a significant global health challenge, affecting both pulmonary and extrapulmonary sites and yielding diverse radiological manifestations. These manifestations, ranging from subtle parenchymal changes to overt abnormalities, include features such as infiltrates, nodules, cavitations, and pleural effusion, often reflecting disease stage, immune status, and anatomical site involvement. Understanding these manifestations is crucial for accurate diagnosis and timely intervention, with radiographic imaging techniques such as chest X-rays and CT scans playing pivotal roles in evaluating TB, alongside advancements in technology enhancing detection and characterization of TB-related abnormalities.
Methods
A retrospective cross-sectional study was conducted utilizing patient records and imaging data collected from 2020 to 2023. Inclusion criteria comprised patients diagnosed with tuberculosis (TB) during this period. Ethical approval was obtained from the institutional review board or ethics committee, ensuring patient confidentiality and data anonymization. Informed consent was not required due to the retrospective nature of the study. Statistical analysis was performed using SPSS version 26.0, computing descriptive statistics including frequencies, percentages, means, and standard deviations.
Results
Our study found a 46–54% male-to-female ratio. Tuberculin skin test positivity was 90%, with 85% showing fever elevation. Upper lobe involvement was seen in 75% of cases, with cavitations present in 3% (chest radiograph) and 22% (CT scan). Pleural effusion occurred in 30% (chest radiograph) and 76% (CT scan), with a density exceeding 20 Hounsfield units in 72%. Bronchial wall thickening was noted in 42% (chest radiograph) and 85% (CT scan). Tree-in-bud appearance was observed in 68% (chest radiograph) and 82% (CT scan). Initial upper lobe involvement with tuberculosis was found in 92% of cases. Hilar lymphadenopathy was present in 69% (chest radiograph) and 88% (CT scan), with lymph nodes measuring 15–20 mm most common at 63%. High-density nodes were seen in 81% and peripheral enhancement in 82% of cases. Lymph nodes in the right hilum were most prevalent at 90%. Segmental consolidation was highest at 85%, with heterogeneous density on CT scan observed in 63% of cases. Thick-walled cavities were seen in 69%, and centrilobular nodules (1–3 mm diameter) were observed in 92%. High-resolution CT scan demonstrated 90% accuracy in diagnosing tuberculosis.
Conclusions
Early diagnosis of tuberculosis (TB) is crucial to prevent adverse outcomes. Radiological diagnostic methods play a vital role in identifying TB and its manifestations. This study explores key radiographic signs of primary and post-primary TB, along with their complications. Additionally, it evaluates the accuracy of radiographic imaging in TB diagnosis.
Formulation and Evaluation of Hydrogel Matrix Tablets of Terazosin Hydrochloride
Authors: DEEPTHI BACHALA , kamere kishore , G.Vijaykumar
Published: February 2024

The aim of present investigation was formulation and development of Terazosin HCl Sustained Release Matrix Tablets. Study started from the preformulation study of the drug. Drug having good solubility in both dissolution mediums. The flow of API is low so directly compressible excipient used for tablet preparation. While studying IR spectrum, we can conclude that there is no interaction between drug and other excipients. Initially feasibility trials were taken using HPMC K4M and K100M. Tablets were found acceptable in physical parameters evaluation. During drug release evaluation amount of HPMC K4M increases the drug release for long period of time. In contrast less amount of HPMC K100M helps in drug release. So role of polymer concentration is very important in this formulation. Based on that F3 batch found satisfactory and considering for further factorial screening. 32 factorial design applied by taking HPMC K4M and PVP K-30 as independent factors. Factorial batch P1-P9 prepared by using direct compression method. Physical and chemical evaluation was done for all batches. PVP K-30 and HPMC K4M significantly impact on Drug release and hence the model found significant. Finally the optimized batch P12 taken based on Contour plot and evaluation done. Batch P12 load for stability for 1 month and found stable. Hence the batch P12 was optimized batch.
The Effect of Gamal Leaf (Gliricidia sepium (Jacq.) Kunth ex Walp)-based Liquid Organic Fertilizer on The Vegetative Growth of Lettuce (Lactuca sativa L.)
Authors: Nisa Chairul , Idris M , Rahmadina
Published: February 2024

The growth of lettuce depends on the interaction of growth and environmental conditions. Improper crop maintenance may cause low yield of lettuce production. Application of liquid organic fertilizer could be performed as a strategy in crop maintenance. This study aimed to determine the effect and concentration of gamal leaf (Gliricidia sepium (Jacq.) Kunth ex Walp)-based liquid organic fertilizer (LOF) on the vegetative growth of green lettuce plants (Lactuca sativa L.). The research method used a non-factorial Randomised Group Design (RGD), with treatments consisted of P0 (control), P1 (20% gamal leaves-based LOF), P2 (40% gamal leaves-based LOF), and P3 (60% gamal leaves-based LOF). The results showed that Gamal leaves-based liquid organic fertilizer (LOF) that is produced in this research might still contain less macronutrients C, N, P and K that is stated by SNI 7763: 2018 (2-6%), but its application on lettuce as tested plants could still support their growth. Dose of P1 (20%) was the best to support lettuce growth in the form of increased plant height and leaf area index. Dose of P2 (40%) was abble to maintain showed minimum decrease on lettuce total chlorophylls content. Application of dose of P2 (40%) on lettuce growth medium supportes highest uptake of N while the application of dose of P3 (60%) showed highest uptake of P.
Avaliação do ajuste de dose de antimicrobianos pela função renal em unidades de terapia intensiva
Authors: Da Silva Manoela Santos , Mascarenhas Ana Mercia Silva , Santana Tamiles Daiane Borges , Da Silva Beatriz Santos , Bomfim Danilo Miranda , Souza Bianca Oliveira , Lemos Lucas Brasileiro , Lemos Gisele da Silveira
Published: February 2024

Objetivo: Identificar os fatores associados ao ajuste de dose de antimicrobianos pela função renal em pacientes internados em Unidades de Terapia Intensiva (UTI). Método: Estudo transversal, descritivo-analítico, com coleta de dados referente ao período de julho a dezembro de 2019 em três UTI. Foram incluídos pacientes internados nestas unidades, com prescrição de antimicrobianos e excluídos os sujeitos com permanência menor que 24 horas na UTI e idade inferior a 18 anos. A associação entre variáveis dependentes e as independentes foi realizada por meio de análise univariada, utilizando o modelo de regressão logística binária. A magnitude da associação foi calculada usando odds ratio (OR) com intervalos de confiança de 95% (IC) e p <0,05. Resultados: Do total de 290 pacientes, 55,0% eram do sexo masculino e 54,1% idosos (≥ 60 anos). Verificou-se o uso de 738 antimicrobianos. Desses, 276 necessitaram de ajuste de dose, e 99,6% foram realizados, destacando-se a Piperacilina + Tazobactam, e Ampicilina + Sulbactam, os mais frequentes. A creatinina alterada (OR=9,753 IC=6,876–13,833), interconsulta com o Nefrologista (OR=4,431 IC=3,035–6,470) e o acompanhamento farmacêutico (OR=1,415 IC=1,046-1,914), estiveram associados estatisticamente com a realização de ajuste de dose, pela taxa de filtração glomerular (TGF). Os achados revelaram significativa associação entre alteração da TFG e creatinina e a realização de ajuste de dose de antimicrobianos. Conclusão: Verificou-se alta realização de ajuste de dose e associação estatística entre creatinina alterada, consulta com nefrologista e acompanhamento farmacoterapêutico com a realização do ajuste, reforçando a importância de especialistas e dos farmacêuticos clínicos nas UTI.
Analysis of Public Service Management of the Youth and Sports Education Service during the Pandemic Period
Authors: Erfanto Mohamad Ali , Mubarok Ferry Khusnul , Haryati Yuli , Arifin Johan
Published: February 2024

The existence of a pandemic has had an impact on the quality of public services in various institutions, which has caused a decrease in satisfaction due to various changes. The purpose of this study was to analyze management and determine the level of satisfaction with public service management carried out by staff of the institutional and infrastructure division of Early Childhood Education and Non-Formal Education at the Youth and Sports Education Office of Rembang Regency. District during a pandemic. The method used in this study is descriptive, by first analyzing the results of the questionnaire qualitatively, while the results of the interviews are presented descriptively. There are two data collection techniques used, namely by giving questionnaires and by conducting interviews. From this study it was found that indicators of achievement in knowing the level of community satisfaction can use measurements from five dimensions, namely responsiveness, reliability or reliability, assurance or certainty and certainty, empathy, and tangible or physical evidence. The conclusion that can be drawn is that management in public services is very important in the delivery of services, guided by these five dimensions, public service providers are expected to be able to improve services in order to create comfortable conditions for the community as service recipients.
Pengaruh Corporate Social Responsibility Terhadap Nilai Perusahaan dengan Ukuran Perusahaan sebagai Variabel Moderasi
Authors: Saragih Ambrosia Silviana Sari , Said Hilda Salman
Published: February 2024

Purpose: Firm value is business performance as indicated by stock price, which reflects how investors perceive business success. This study aims to determine the effect of corporate social responsibility (CSR) on company value in energy sector companies listed on the Indonesia Stock Exchange in 2018-2021 both simultaneously and partially by using company size as a moderating variable.
Methodology/Approach: Energy sector companies listed on the Indonesia Stock Exchange from 2018 to 2021 are the main subjects of this research. Sampling using purposive sampling technique, resulting in 10 companies and 40 total data. The method used is panel data regression analysis and moderating regression analysis. Data processing was carried out using Eviews 12 software.
Findings: The results of this study indicated that simultaneously, corporate social responsibility and company size have a significant influence on firm value. However, when analyzed partially, corporate social responsibility does not have a significant effect on firm value. On the other hand, company size partially affects firm value. Even so, company size does not act as a moderator between corporate social responsibility and corporate value.
Practical and Theoretical Contribution/Originality: However, in describing the value of energy sector companies listed on the Indonesia Stock Exchange from 2018 to 2021, CSR and company size have a strength of 85%.
Mathematical modeling and prediction of values of partial indicators of heat-exchange processes at underwater wet welding
Authors: Soe Kiav Min , Murzin V. V. , German G. V.
Published: February 2024

At computer modeling of heat-exchange processes there arises a necessity of parametric forecasting of values of partial indicators of multifactor systems of underwater wet welding. Ensuring the reliability of such a prediction makes it possible to use the obtained models for engineering calculations in the design of technological welding processes. On the example of experimental data on the estimation of gas formation in the process of arc combustion the methodology – approved in shipbuilding production – is proposed. Mathematical dependences providing the minimum error of estimation at changing the values of influencing parameters, are obtained. The formation of gas bubbles significantly affects the heat-exchange processes in underwater welding, which determines the cooling rate of the welded joint and affects the formation of hardening structures.