bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing interaction models that meet user expectations towards new technologies
Authors: Talug Deniz Yesim
Published: November 2018

Currently, technology is an interesting and expanding field for social and consumer research. Conversely, standard consumer researches, academic marketing studies, economics or sociology fall short of representing theories and perspectives that ties technology and human needs. New technological opportunities not only create changes in appearance and functionalities of products but it also creates change on user expectations and behaviors, which is mainly emotionally driven. Needs and emotions lead people to make judgments about what they would prefer to keep around themselves. This characteristic of human beings forces them to choose among variants and to involve in the design process. Selecting among variants means designing of the environment. In the study of design, the idea of consumer participation offered new horizons to design.

 

This paper focuses on new perspectives to combine technology and human beings and aims to provide theoretical contribution and strategic information to the designers, progresses through a discussion of the conceptual framework with a review of the relevant literature. Initial attempt involves investigating user experiences created and shaped through technology and how to deliberately design those.

 

Keywords: Emotions and Design; User Experience; Product Experience; Technology.
Message from Editor
Authors: Ilhan Prof. Dr. Ayse Cakir
Published: November 2018

Message from EditorDear Readers,It is a great honor for us to publish eight volume, second issue of Global Journal of Arts Education.Global Journal of Arts Education is an international peer-refereed journal that provides aninternational form for research in the field of the art and creative education. The journal welcomes awide range of theoretical and methodological approaches to research, and encourages submissionsfrom the broader fields of education and the arts that are related with learning and teaching throughart education. The journal publishes original research articles or comprehensive reviews o n design,culture, architecture, aesthetics, arts history, arts ethics, graphic design and ceramics that are relatedwith the area of education.Articles focusing on designing interaction models that meet user expectations towards newtechnologies, aesthetic sensibility and technical skills of an architect as a result of the fine artslearning—curricula changes at the faculty of architecture, silesian university of technology ingliwice, an analysis of ‘typographic self-portrait projects’ by the 2nd grade students of baskentuniversity, faculty of fine arts, design and architecture, department of visual arts and design,design thinking…inspiring innovation, transforming humanity, makerspaces and scientificcreativity level of middle school students, the lord of the postmodernity: plagiarism have beenincluded in this issue.The topics of the next issue will be different. You can make sure that we will be trying to serve youwith our journal with a rich knowledge in which different kinds of topics are discussed in eachvolume and issue.A total number of twelve (28) manuscripts were submitted for this issue and each paper has beensubjected to double-blind peer review process by the reviewers specialized in the related field. At theend of the review process, a total number of four (6) high quality research papers were selected andaccepted for publication.We present many thanks to all the contributors who helped us to publish this issue.Best regards,Prof. Dr. Ayse Cakir IlhanEditor – in Chief
Modelling and power control of grid connected wind energy system
Authors: Ben Si Ali Nadia , Benalia Nadia , Zerzouri Nora
Published: November 2018

Wind energy generation has attracted great interests in recent years. Doubly-fed induction generator (DFIG) for wind turbines (WTs) are largely deployed, because variable-speed WTs have many advantages over fixed-speed generation such as increased energy capture, operation at maximum power point, improved efficiency and power quality. This paper presents the operation and vector control of a DFIG system, where the stator is connected directly to a stiff grid and the rotor is connected to the grid through bidirectional back-to-back ACâ€“DCâ€“AC converter. The basic operational characteristics, mathematical model of the aerodynamic system and vector control technique, which is used to obtain decoupled control of powers, are investigated using the software Matlab/Simulink.

 

Keywords: Wind turbine, doubly-fed induction generator, active and reactive power controller.
Study and identification of short-circuit currents at the Complex Distribution Network SIDER-EL Hadjar (ex ArceloMittal-Algerie)
Authors: Hakim Benhamida , Tarek Mesbah
Published: November 2018

Because of an upcoming the modernization of the electricity distribution network in the SIDER EL-HADJAR steel complex, a new calculation of the short-circuit current must be taken into account. The objectives pursued in this article, is to determine the precise values of the currents of maximum and minimum fault by each start 225kV, 63kV and 15kV of the distribution network to ensure the reliability of the existing system, on the other hand is to validate the sizing of the 63kV bus bar follows the increase of the load of the transformer station P4 by replacing the 70MVA transformer with a 120MVA transformer and comparing the results to the old computation. The calculation of short-circuit currents is a key step in qualifying the equipment to withstand the thermal and electromagnetic effects. So it was question of appreciating the reliability of numerical computation of the currents of short-circuits which requires modeling and simulations with software NEPLAN V5.
Introducing a software for innovative neuro-fuzzy clustering method named NFCMR
Authors: Shirazi Aref , Shirazy Adel , Saki Shahab , Hezarkhani Ardeshir
Published: November 2018

An innovative neural-fuzzy clustering method is for predicting cluster (anomaly / background) of each new sample with the probability of its presence. This method which is a combination of the Fuzzy C-Means clustering method (FCM) and the General Regression Neural Network (GRNN), is an attempt to first divide the samples in the region by fuzzy method with the probability of being in each cluster and then with the results of this Practice, the artificial neural network is trained, and can analyze the new data entered in the region with the probable percentage of the clusters. More clearly, after a full mineral exploration, the sample can be attributed to a certain probable percentage of anomalies. To test the accuracy of this clustering in the form of the theory alone, a case study was conducted on the results of the analysis of regional alluvial sediments data in Birjand, IRAN, which resulted in satisfactory results. This software is written in MATLAB and its first application in mining engineering. This algorithm can be used in other similar applications in various sciences.
Influence of Selected Institutional Factors on the Impact of Constituency Development Fund in Financing Education in Public Secondary Schools in Ndaragwa Constituency, Kenya
Authors: Gicheru Ndei Joseph , Kanjogu Kiumi John , Githae Kaboro Peter
Published: November 2018

Access to secondary education in public secondary schools in Kenya has not been fully achieved due to rising costs in education. The Kenya government has therefore devised policies to help address issues of education access and retention through establishment of cost subsidies. The Constituency Development Fund (CDF) was established in 2003 through an Act of Parliament. The main objective was to mitigate the imbalance in regional development and provide people at the grassroots an opportunity to make expenditure choices that maximize their welfare in line with their needs and preferences. A key focus of CDF was to provide a devolved system of financing education. However, the extent to which CDF has succeeded in achieving this noble aim has not been evaluated. The focus of this study therefore was to find out the extent to which CDF as a means of financing education has succeeded in improving physical facilities, enhancing enrolment and reducing dropout rates in secondary schools in Ndaragwa Constituency, Kenya and to determine whether the impact is related to school type, enrolment, age and sponsorship. The study adopted an Ex-post facto research design where data were collected using self-administered questionnaires to 25 principals. Data were analyzed through descriptive and inferential statistics. Hypotheses were tested using ANOVA and t-test at an alpha level of 0.05. The study established that there is no significant relationship between the impact of CDF in financing education and school type, enrolment, age and sponsorship. Based on the findings, the study recommends that CDF framework should be revised in order to assist schools to address pertinent issues facing them and to improve the quality of education in all secondary schools in Kenya.
Okul Müdürlerinin Demokratik Tutumları
Authors: GÜL İbrahim , SARAÇ Günay
Published: November 2018

Okulun siyasal işlevini etkili olarak yerine getirmesi,
okulu yöneten müdürlerin demokratik tutumlarına bağlıdır. Bu araştırmanın
amacı, öğretmen görüşlerine göre, okul müdürlerinin demokratik tutumlarını
ortaya çıkarmaktır. Araştırmanın yöntemi nitel bir çalışma olup, veriler
araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu ile
toplanmıştır. Araştırmada elde edilen verilerin çözümlenmesinde betimsel ve
içerik analizi kullanılmıştır. Görüşmecilerin doldurmuş olduğu formlar önce
numaralanmış ve sonra bunlar analize tabi tutulmuştur. Elde edilen kavramlardan
kategorilere ve temalara ulaşılmaya çalışılmıştır. Araştırma bulgularına göre,
öğretmenler demokratik tutum kavramını “eşitlik ve hakkaniyet” olarak
değerlendirmişlerdir. Öğretmenlerin çoğunluğu okul müdürlerinin demokratik
tutuma sahip olmadığı görüşündedirler. Okul müdürlerinde eksik gördükleri
demokratik tutumlar, ayrımcılık yapma, yeniliklere açık olmama, başkalarının
fikirlerini almama olarak sıralanmıştır. Okul müdürünün demokratik tutuma sahip
olmaması halinde, eğitim öğretimin olumsuz etkileneceğini, güven, bağlılık ve
motivasyonun azalacağı vurgulanmaktadır. Öğretmenler, demokratik bir müdürde
bulunması gereken davranışları, farklı görüşlere saygı duyar, adaletli davranır
ve yeniliklere karşı açıktır olarak nitelendirmişlerdir. Okul müdürlerinin
demokratik tutum ve davranışlarını geliştirmeye yönelik eğitim almaları
önerilmiştir.
Comparative Analysis of Erbium Doped Fiber Amplifier (EDFA) and Raman Optical Amplifier (ROA) in Nonlinear-CWDM System
Authors: Zulherman Dodi , Utami Sri , Fahmi Fahmi
Published: November 2018

The massive demands for high-rate application drove the telecommunication service to use large bandwidth capacity. The Coarse Wavelength Division Multiplexing (CWDM), a common use in Metro-WDM, can be a solution to provide large bandwidth in optical communications. In a communications system, there are attenuation and nonlinear effect decreasing the system performance. In order to overcome the limitation imposed by electrical regeneration to maintain system performance, a means of optical amplification was sought. In this paper presents the comparison of two competing technologies emerged: Erbium Doped Fiber Amplifier (EDFA) and Raman Optical Amplifier (ROA) to overcome the attenuation in the nonlinear system. We designed the CWDM system using 8 channels with 20 nm channel spacing and 60 km length. The result was conducted by varying the CW Laser power using -8, -6, -4, -2, 0, 2, 4, and 6 dBm. Based on the result of the research, raman amplification can maintain the BER and the Q-factor of the CWDM system better than EDFA. In addition, the received power in raman amplification larger than that received in EDFA. In conclusion,a CWDM system using ROA amplifier has better performance for the system than using EDFA amplifier.
Improved Load Balancing on Software Defined Network-based Equal Cost Multipath Routing in Data Center Network
Authors: Dewanto Ramadhika , Munadi Rendy , Negara Ridha Muldina
Published: November 2018

Equal Cost Multipath Routing (ECMP) is a routing application where all available paths between two nodes is utilized by statically mapping each path to possible traffics between source and destination hosts in a network. This configuration can lead to congestion if there are two or more traffics being transmitted into paths with overlapping links, despite the availability of less busy paths. Software Defined Networking (SDN) has the ability to increase the dynamicity of ECMP by allowing controller to monitor available bandwidths of all links in the network in real-time. The measured bandwidth is then implemented as the basis of the calculation to determine which path a traffic will take.  In this research, a SDN-based ECMP application that can prevent network congestion is made by measuring available bandwidth of each available paths beforehand, thus making different traffics transmitted on non-overlapped paths as much as possible. The proposed scheme increased the throughput by 14.21% and decreased the delay by 99% in comparison to standard ECMP when congestion occurs and has 75.2% lower load standard deviation in comparison to round robin load balancer.
Design and Analysis of Trash Monitoring System Prototype Based On Internet of Things (IoT) Using MQTT Protocol
Authors: Zulfikri Achmad Auliyaa , Perdana Doan , Bisono Gustommy
Published: November 2018

On this research,Internet of Things (IoT) as an advanced technology is used to monitor the height of trash from a trash can in order to give notification whether the height of trash is already reach the maximum limit or not yet.To support those needs,we used NodeMCU as microcontroller,ultrasonic sensor,MQTT as IoT protocol,and also Android application to show the data.After we did the system performance test,we got the biggest result of end-to-end delay which is 2.06875 seconds when the packet delivery is set to 1000 ms with 3 active nodes and the smallest result which is 0.26055 seconds when the packet delivery is set to 100 ms with 1 active mode.The biggest result of throughput is 597.17 Bytes/s when the packet delivery is set to 100 ms with 1 active mode and the smallest result is 75.86 Bytes/s when the packet delivery is set to 1000 ms with 3 active nodes.The biggest result of availability and reliability is 99.905% when the packet delivery is set to 1000 ms and the smallest result is 99.833% when the packet delivery is set to 100 ms.
Performance Analysis of Reactive Routing Protocol on VANET with Wormhole Attack Schemeaper
Authors: Ratnasih Ratnasih , Perdana Doan , Wulandari Triani , Pratama M. Irfan
Published: November 2018

Entering the information era, the current needs of global community is increasing very rapidly. Vehicular Ad-hoc Networks (VANET) has drawn significant attentions from both industry and academia as an important developmnt of vehicular communication technology. VANET is one of open network and communication media without security mechanism. There are many kinds of security threat that can interrupt data communication in VANET. Wormhole attacks as one of security threat can be a good challenge in VANET security research.  In this paper, we evaluate performance of reactive routing protocol on VANET with wormhole attack scheme. The project is simulated using NS-3 in Ubuntu platform with performance analysis of routing protocol by changing of initial power and node density. We conclude that throughput values are increasing along with the changing of initial power while the delay values are decreasing rapidly. By the changing of node density, the highest delay value is 0.122 ns on 10 nodes condition and 0.215 Mbps for throughput value on 8 nodes condition.
Trajectory Tracking Control System Design For Autonomous Two-Wheeled Robot
Authors: Uddin Nur
Published: November 2018

A trajectory tracking control system design of an autonomous two-wheeled robot (TWR) is presented. The control system objective is to steer the TWR move on a desired trajectory in planar space. The TWR has two kinds of movement: moving forward/backward and turning to the right/left, where the movements are represented by a non-linear kinematics equation. Simplifying the trajectory tracking control system design, the non-linear kinematics equation is approximated by a linear kinematics equation. Linear quadratics regulator (LQR) method is applied to design the trajectory tracking control system. The designed control system is evaluated through computer simulation. Simulation results show that the designed control system is able to make the TWR track a desired trajectory that located 1.4 meter away from the TWR initial position within 3 seconds.
ROLE OF THE PERICARDIOSCOPY IN THE TREATMENT OF PERICARDIAL EFFUSION
Authors: Pisklova Yulia
Published: November 2018

In recent years surgical treatment of pericardial effusion has been favoured by mini-invasive interventions. Pericardioscopy supplements it. In the literature actively discusses its expediency, efficiency and informativeness.

Aim of the study. Analyze our experience of using pericardioscopy during surgical treatment of pericardial effusion using mini-invasive interventions.

Materials and methods. From 2000 to 2017, 92 patients with pericardial effusion were operated in our clinic using mini-invasive interventions. Pericardioscopy was used in 72 (78.26 %) cases. In 32 (44.44 %) pericardioscopy was performed with subxiphoid pericardiotomy, in 40 (55.56 %) – with thoracoscopy on the right or left side.

Results and discussion. The use of pericardioscopy has allowed to significantly reduce the number of idiopathic pericarditis from 20.0 % to 5.56 % and increase the informativeness of the minimally invasive interventions by 14.44 % (χ2 = 4.11, with ν = 1, α = 5 %). There is no reliable difference in the number of relapses of the disease.

Conclusions. The use of pericardioscopy during mini-invasive interventions is safe and effective. The method of choice in most cases is subxiphoid non-pleural pericardiotomy with pericardioscopy.
THE ROLE OF PROTOZOAL INFESTATIONS IN CHRONIC INFLAMMATION EXACERBATIONS IN PATIENTS WITH GENITOURINARY PATHOLOGY
Authors: Fedorych Pavlo , Mavrov Gennadiy
Published: November 2018

The aim: to study the prevalence of protozoal infestations in cases of acute inflammatory exacerbations in genitourinary clinic.

Materials and methods. The method of polymerase chain reaction was used to examine 158 subjects with chronic inflammation of the genitourinary system exacerbations.

Results. Infestation of the genitourinary system was identified in 72 patients (45.6 %). Trichomonas infestation was identified in 63 (87.5 %) of them. Trichomonas vaginalis was identified in 1 (1.4 %) subject. Other Trichomonas species – in 62 (86.1 %) subjects. 12 (16.7 %) had Trichomonas tenax, and 50 (69.4 %) – Pentatrichomonas hominis. Giardia lamblia was identified in 9 patients – i.e. in 12.5 % individuals with infestation of the genitourinary system, or in 5.7 % among subjects examined for STIs in this study.

Conclusions: High level of Trichomonas infestation of the genitourinary system was identified in subjects with of chronic inflammatory exacerbations of the genitourinary system. In most cases, infestations were caused by Trichomonas species other than Trichomonas vaginalis, as well as by Giardia lamblia. An assumption about a certain role of these pathogens in the onset or further course of inflammatory diseases of the genitourinary system was made.
ESTIMATION OF RESERVES FOR IMPROVING THE RESULTS OF PATIENTS WITH MULTIPRESISTANT PULMONARY TUBERCULOSIS IN THE APPLICATION OF SURGICAL METHODS BASED ON ANALYSIS OF THE EFFICIENCY OF CONSERVATIVE TREATMENT OF A SPECIFIED COHORT
Authors: Khmel Oleg , Kalabukha Igor , Ivashchenko Vladimir
Published: November 2018

In order to improve the results of treatment of patients with multi-resistant pulmonary tuberculosis with the use of surgical methods, the effectiveness estimation of conservative treatment of 176 patients with this form of tuberculosis according to cohort analysis data in two districts of Kyiv were done. In the list were included following parameters: type of the tuberculosis, its clinical-radiological form and the prevalence of the process, the results of conservative treatment in patients who completely finished the course of anti-TB chemotherapy and the results of conservative treatment of 81 patients who had indications for surgical treatment but had not been operated. Processing of the materials of the study was carried out with the use of licensed software products included in the Microsoft Office Professional 2007 package. The predicted results of treatment were calculated on the condition of surgical intervention. Out of the total sample of patients, 31.3 % of the patients completed treatment. Mortality was 16.5 %, transferred to palliative care 11.9 %. More than one in three patients (35.2 %) stopped treatment at different times from the start. According to the clinic of thoracic surgery SU "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky NAMS of Ukraine ", the overall effectiveness of treatment for patients with limited multidrug-resistant tuberculosis with the use of surgical intervention is about 95 % in the absence of mortality. We have modelled the potential results of treatment of the selected cohort in case of the surgical stage is fully and timely applied in a complex of therapeutic treatment. If all 81 patients with indications for surgical treatment used that way, then, with the above efficiency, a complete cure could be predicted in 77 patients (44.5 % of the total number of observations), which in turn would allow predicting the achievement completion of treatment at 64.2 % with complete cure for 60.6 % of patients. Thus, it is established that the positive result of surgical treatment in the general complex of treatment measures in patients with multidrug-resistant pulmonary tuberculosis is able to improve the results of treatment of this contingent more than twice, reduce the mortality almost by three times, reduce the need for repeated courses of treatment from 7.4 % to 1.7 %, as well as to reduce the epidemiological reservoir of infection due to a significant decrease in the number of patients with failure to treat tuberculosis, interrupted and palliative treatment.
DEVELOPMENT OF PROTEIN-FAT EMULSIONS BASED ON VITAMINIZED BLENDED VEGETABLE OILS
Authors: Kotliar Yevhenii , Topchiy Oksana , Kyshenia Andrii , Polumbryk Maksym , Garbazhiy Kateryna , Lanzhenko Liubov , Honcharenko Taisa
Published: November 2018

The article analyzes protein components of different nature, based on studies. It proves a possibility of their use as components of protein-fat emulsions for modeling rational recipes. It determines the rational physical parameters of the emulsification process that guarantee high-quality homogenous emulsions. It investigates the samples of protein-fat emulsions with using fatty components and partial replacing animal fats for vitaminized blending of vegetable oils.

According to the results of the studies of the influence of the recipe components on the quality of protein-fat emulsions and also practical recommendations for protein preparations, there were developed the recipes of multi-component protein-fat emulsions, including vitaminized blended vegetable oils and protein components: “Belkoton А91», «Forward 450», «Supro 500Е».

Based on the received experimental data, there were determined the rational parameters of emulsification, namely, speed of the process − 3000 turns/min and total duration of the process – 6…10 min and also there was established, that it is expedient to enrich the content of meat pastes with protein-fat emulsions in amount 15…20 %.

Thus, the development of recipes of protein-fat emulsions (PFE) is an urgent problem for creating balanced meat products. It will allow to replace fat of the animal origin for vitaminized blended vegetable oils (VBVO) in them, in such a way enriching them with fatty acids and vitamins.
INDICATORS OF THE ELEMENT RANGE OF RAT’S BLOOD IN TERM ARTIFICIAL HYPOBYOSIS
Authors: Umanska Anna , Melnichuk Dmytro , Kalachnyuk Lilia
Published: November 2018

The promising method of anesthesia and anesthesia is the state of artificial hypobiosis. Hypercapnia is a prerequisite for creating an artificial carbon dioxide hypobiosis, along with hypoxia and hypothermia. Adhering to the conditions under which the state of artificial carbon dioxide hypobiosis is created, animals reduce the level and intensity of metabolic processes both in the body as a whole and in separate organs. In order to investigate the safety of the hypobiological state and evaluate its applicability in clinical practice, it is necessary to investigate the functional characteristics of the blood. One of the most important indicators is the change of elemental composition. After all, the set of micro-and macro-elements is involved in the enzymatic reactions of the organism, its metabolic processes.

Therefore, the aim of the study was to investigate the elemental changes in the blood of rats for artificial hypobiosis. In experiments, white non-breeding male rats weighing 180–200 g were used, which were maintained under standard vivarium conditions. Animals were divided into 2 groups: control and experimental (the state of artificial hypobiosis). Each group had 7 animals. Measurement of the content of macro- and micronutrients was carried out using a mass spectrometric ionization method in an inductively coupled plasma on an IRIS Interband II XSP device manufactured by Thermo Scientific, USA. The results of the study were processed and presented using the methods of statistical analysis, namely: the method of descriptive statistics; Shapiro-Wielka's criterion for choosing a statistical criterion for comparing groups; Student's criterion; Mann-Whitney's criterion. Results of evaluation of dynamics in the experimental (hypobiotic) group using the criterion of sign-marks of Wilcoxon. As a result of the studies, increased levels of Sodium, Ferrum, Calcium were observed, while the content of Nickel and Barium reduced. The results of the analysis of the dynamics of blood parameters in the experimental group by the methods of descriptive statistics showed significant changes in such elements as: Potassium, Sodium, Ferrum, Calcium, Magnesium. The heterogeneity of the results of the experimental and control groups according to the Mann-Whitney criterion was demonstrated in the following elements: Potassium, Sodium, Ferrum, Calcium, Chromium, Strontium.
INVESTIGATION OF THE INFLUENCE OF ANTIMICROBIAL PREPARATIONS ON THE SHELF LIFE OF BROCCOLI CABBAGE
Authors: Pusik Ludmila , Pusik Vlаdimir , Lyubymova Nina , Bondarenko Veronika , Gaevaya Ludmila
Published: November 2018

Studies of the effect of antimicrobial agents on the conservation of broccoli cabbage have been conducted. The late hybrids of broccoli Ironman F1, Agassi F1, Beaumont F1, grown under the conditions of the Forest-Steppe of Ukraine were studied. The content of the main components of the chemical composition (dry substances, dry soluble substances, sugars, vitamin C) of broccoli cabbage is analyzed depending on the characteristics of the hybrid. The effect of antimicrobial treatment on the natural loss of cabbage, microbiological lesions during storage has been studied. Antimicrobial preparations Baikal EM-1 (dilution of working solution in water 1: 500), 0.5 % solution of citric, 0.2 % benzoic, 0.05 % sorbic acid, and also 0.5:0.5 % solution of vitamins C and P (ascorutin), water for the preparation of solutions had a temperature of 23 ... 25 °C.

The processing of fruit and vegetable products with various chemicals is aimed at prolonging the shelf life, increasing the shelf life and increasing the yield of commercial products at the end of storage.

It is established that the natural loss of broccoli cabbage during storage depends on the characteristics of the hybrid and the type of antimicrobial preparation. Treatment with preparations increases the shelf life of broccoli cabbage to 30 - 50 days with a natural weight loss of up to 6.1 %, and ensures minimal disease burden.

Treatment with antimicrobial agents reduces the loss of dry substances, dry soluble substances, sugars, vitamin C. The most effective is the treatment of broccoli with acids. It has been established that ascorbic acid is contained in broccoli cabbage, with hydrolysis from which ascorbic acid is split off, the content of which is increased.

The maximum effective storage of broccoli cabbage at a temperature of 0 ± 1 oС and relative humidity of 90-95 %, pretreatment with preparations of antimicrobial action.

The proposed method of processing broccoli cabbage with antimicrobial preparations before storage allows the use of vegetable raw materials for post-harvest treatment. In the development of new, low-cost, environmentally friendly and affordable storage technologies, this is an important technique.
INVESTIGATION OF TECHNOLOGICAL PROPERTIES OF POWDER OF EGGPLANTS
Authors: Dzyundzya Oksana , Burak Valentyna , Averchev Alexander , Novikova Natalya , Ryapolova Irina , Antonenko Artem , Brovenko Tetiana , Kryvoruchko Myroslav , Tolok Galina
Published: November 2018

The aim of the article is to study and to generalize technological properties of eggplant powder, produced by infrared drying at temperatures 50-60 ºС. The results of the conducted complex of studies reflect main technological and consumption properties of the received puree that plays an important role at creating new culinary products.

So, for studying technological properties of food eggplant powder, there was considered the complex of base functional-technological properties of powder, produced by infrared drying.

For finding optimal conditions of rehydration of eggplant powders, there was studied the influence of such technological factors as: swelling ability; liquid; powder ratio; influence of the solvent temperature on renovation; renovation duration; degree of comminution of powders.

Main parameters that influence the renovation ability of dried eggplants are investigated and studied in the article. The results of the studies of technological properties of eggplant powders prove their high rehydration properties. It gives a possibility to use powders at producing different culinary products not only for enriching them with functional ingredients, but also for giving them new technological properties.

Based on the obtained results, there was elaborated and presented the new technological scheme of using renewed powders in food compositions.
Debt maturity and corporate R&D investment – the empirical study of US listed firms
Authors: Yu Hai-Chin , Phan Thi-Thanh
Published: November 2018

This study investigates the relationships between debt maturity structure and corporation R&D investment. Using a large sample of US listed firms over the period of 1995 to 2015, it was found that the use of bank debt positively influences R&D investment, whereas the use of public debt exerts a negative impact. However, the Sarbanes-Oxley Act (SOX) mitigates the information asymmetry such that the advantages of private information from banks shrunk. As a result, public debtholders benefit more from the SOX and turn out to be positively influenced by the R&D investment after SOX. Moreover, bank debt impact on R&D spending reduces over the post-SOX. The results also find that the SOX influences the debt maturity on corporate R&D investment only for large corporations, the effects remain unchanged for small businesses.
Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery
Authors: Xiao Xiao , Oswald James Trevor , Wang Ting , Zhang Weina , Li Wenliang
Published: November 2018

As one of the leading and most important metal-based drugs, platinum-based pharmaceuticals are widely used in the treatment of solid malignancies. Despite significant side effects and acquired drug resistance have limited their clinical applications, platinum has shown strong inhibitory effects for a wide assortment of tumors. Drug delivery systems using emerging technologies such as liposomes, dendrimers, polymers, nanotubes and other nanocompositions, all show promise for the safe delivery of platinum-based compounds. Due to the specificity of nano-formulations; unwanted side-effects and drug resistance can be largely averted. In addition, combinational therapy has been shown to be an effective way to improve the efficacy of platinum based anti-tumor drugs. This review first introduces drug delivery systems used for platinum and combinational therapeutic delivery. Then we highlight some of the recent advances in the field of drug delivery for combinational therapy; specifically progress in leveraging the cytotoxic nature of platinum-based drugs, the combinational effect of other drugs with platinum, while evaluating the drug targeting, side effect reducing and sitespecific nature of nanotechnology-based delivery platforms.
Herbal Products Regulations in a Few Countries-A Brief Overview
Authors: Bhat Bhavana Brahmananda , Udupa Nayanabhirama , Sreedhar Dharmagadda
Published: November 2018

Herbal medicines have been used by mankind from time immemorial. Moreover, many
modern medicines are originated from plant sources. In earlier days, patients were dependent on herbs
for treatment and well-being. However, due to the advent of the industrial revolution and modern science,
the scenario of treating diseases has changed over a period of time. Majority of patients started
preferring allopathy medicines due to their several advantages over herbal medicines. However, due to
long term treatment by allopathic medicines for chronic diseases led to side effects, patients are now
drifting back to the traditional medicines. Herbal medicines have their own drawbacks, viz., lack of
safety and efficacy data, standardization difficulties, not well established legislative controls and a few
issues with adverse drug reactions. Drug regulations per se were always the prime focus and they are
said to be dynamic. There are a few differences in regulations of herbal drugs among various countries.
Regulatory authorities of countries are working to evolve the regulations to govern herbal medicines
more effectively. A brief overview of the regulations related to a few developing and developed countries
have been dealt here.
Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity
Authors: Van Khang Pham , Hien Lan Nguyen Thi , Truong Le Quang , Chau Mai Thi Minh , Truong Mai Xuan , Van Dinh Thuy , Anh Nguyen Thi Quynh , Ma Lei
Published: November 2018

In this report, two new steroidal glycosides were isolated and determined from n-butanol
fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of
known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR
techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated
that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL,
respectively.
Synthesis, Antioxidant and Anti-inflammatory Activities of 5-((styrylsulfonyl) methyl)-1,3,4-Oxadiazol / Thiadiazol-2-amine Derivatives
Authors: Sravya Gundala , Nagarjuna Ummadi , Padmavathi Venkatapuram , Rajitha Galla , priya Sakuri Chandi , Padmaja Adivireddy
Published: November 2018

Background:

A new class of 5-(styrylsulfonylmethyl)-1,3,4-oxadiazol-2-amine and 5-
(styrylsulfonylmethyl)-1,3,4-thiadiazol-2-amine derivatives were prepared by derivatization of amino
function.

Methods:

All the synthesized compounds were tested for antioxidant and anti-inflammatory activities.

Results:

The 2-amino-3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-propanamide
(12b) and 3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-butanamide
(14b) displayed significant antioxidant activity, greater than the standard Ascorbic acid.

Conclusion:

Moreover, 12b and 14b also exhibited promising anti-inflammatory activity
Tall Stature: A Challenge for Clinicians
Authors: Corredor Beatriz , Dattani Mehul , Gertosio Chiara , Bozzola Mauro
Published: November 2018

Clinicians generally use the term “tall stature” to define a height more than two standard
deviations above the mean for age and sex. In most cases, these subjects present with familial tall
stature or a constitutional advance of growth which is diagnosed by excluding the other conditions
associated with overgrowth. Nevertheless, it is necessary to be able to identify situations in which
tall stature or an accelerated growth rate indicate an underlying disorder. A careful physical evaluation
allows the classification of tall patients into two groups: those with a normal appearance and
those with an abnormal appearance including disproportion or dysmorphism. In the first case, the
growth rate has to be evaluated and, if it is normal for age and sex, the subjects may be considered
as having familial tall stature or constitutional advance of growth or they may be obese, while if the
growth rate is increased, pubertal status and thyroid function should be evaluated. In turn, tall subjects
having an abnormal appearance can be divided into proportionate and disproportionate syndromic
patients. Before initiating further investigations, the clinician needs to perform both a careful
physical examination and growth evaluation. To exclude pathological conditions, the cause of
tall stature needs to be considered, although most children are healthy and generally do not require
treatment to inhibit growth progression.

In particular cases, familial tall stature subject can be treated by inducing puberty early and leading
to a complete fusion of the epiphyses, so final height is reached. This review aims to provide
proposals about the management of tall children.
Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration
Authors: He Shi-Chao , Zhang Hui-Zhen , Zhang Hai-Juan , Sun Qing , Zhou Cheng-He
Published: November 2018

Objective:

Due to the incidence of resistance, a series of sulfonamide-derived 1,2,4-
triazoles were synthesized and evaluated.

Method:

The novel sulfonamide-derived 1,2,4-triazoles were prepared starting from commercial
acetaniline and chlorosulfonic acid by sulfonylation, aminolysis, N-alkylation and so on. The antimicrobial
activity of the synthesized compounds were evaluated in vitro by two-fold serial dilution
technique.

Results:

In vitro antimicrobial evaluation found that 2-chlorobenzyl sulfonamide 1,2,4-triazole 7c
exhibited excellent antibacterial activities against MRSA, B. subtilis, B. typhi and E. coli with MIC
values of 0.02−0.16 μmol/mL, which were comparable or even better than Chloromycin. The preliminary
mechanism suggested that compound 7c could effectively bind with DNA, and also it
could bind with human microsomal heme through hydrogen bonds in molecular docking. Computational
chemical studies were performed on compound 7c to understand the structural features
that are essential for activity. Additionally, compound 7c could generate a small amount of reactive
oxygen species (ROS).

Conclusion:

Compound 7c could serve as a potential clinical antimicrobial candidate.
Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles
Authors: Agafonova Natalya , Shchegolkov Evgeny , Burgart Yanina , Saloutin Victor , Trefilova Alexandra , Triandafilova Galina , Solodnikov Sergey , Maslova Vera , Krasnykh Olga , Borisevich Sophia , Khursan Sergey
Published: November 2018

Background:

Formally belonging to the non-steroidal anti-inflammatory drug class
pyrazolones have long been used in medical practices.

Objective:

Our goal is to synthesize N-methylated 1-aryl-3-polyfluoroalkylpyrazolones as fluorinated
analogs of antipyrine, their isomeric O-methylated derivatives resembling celecoxib structure
and evaluate biological activities of obtained compounds.

Methods:

In vitro (permeability) and in vivo (anti-inflammatory and analgesic activities, acute toxicity,
hyperalgesia, antipyretic activity, “open field” test) experiments. To suggest the mechanism
of biological activity, molecular docking of the synthesized compounds was carried out into the
tyrosine site of COX-1/2.

Conclusion:

The trifluoromethyl antipyrine represents a valuable starting point in design of the
lead series for discovery new antipyretic analgesics with anti-inflammatory properties.
Evaluation of Preclinical Aphrodisiac Activity of Flueggea leucopyrus Willd. Leaves
Authors: Vasantrao Usnale S. , Biyani Kailash R.
Published: November 2018

Background:

Flueggea leucopyrus Willd. leaf has been used since ancient time for its sex
enhancing activity by traditional physicians. So, the work was chosen to authenticate the knowledge of
pharmaceutical significance of the plant.

Methods:

The dried leaves of Flueggea leucopyrus were extracted by cold maceration method using
water. Aqueous extract of Flueggea leucopyrus leaf was screened for phytochemicals and in vivo aphrodisiac
activity using mating behavior, potency and morphological tests.

Results:

Qualitative phytochemical analysis of leaves of Flueggea leucopyrus showed the presence of
alkaloids, terpenoids, unsaturated sterols, glycosides, saponins, phenolics, flavonoids, tannins, carbohydrates
and protein. Results revealed that all the treated groups on the 15th, 30th and 45th day of treatment
showed significant increase in Intromission Frequency, Mounting Frequency and Ejaculatory Latency
significant decrease in Intromission Latency, Mounting Latency, Inter Intromission Interval and
Post Ejaculatory Interval. In Test for Potency significant increase in Erections, Long Flips and Quick
Flips were observed. Morphological study showed significant increase in reproductive organs weight
and Sperm Count in all the experimental animals.

Conclusion:

The prolonged treatments for all the treated groups were highly effective to increase the
sexual libidity, as compared to the solvent control. This indicates that aphrodisiac activity has been
shown by water extract but it is less than the standard used for study.
Stem Cell-Mediated Angiogenesis in Tissue Engineering Constructs
Authors: Kiaie Nasim , Aghdam Rouhollah M. , Tafti Seyed H. Ahmadi , Gorabi Armita M.
Published: November 2018

Angiogenesis has always been a concern in the field of tissue engineering. Poor vascularization of engineered constructs is a problem for the clinical success of these structures. Among the various methods employed to induce angiogenesis, stem cells provide a promising tool for the future. The present review aims to present the application of stem cells in the induction of angiogenesis. Additionally, it summarizes recent advancements in stem cell-mediated angiogenesis of different tissue engineering constructs.
A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases
Authors: Zhao Jia , Zhu Mengxia , Kumar Mukesh , Ngo Fung Yin , Li Yinghui , Lao Lixing , Rong Jianhui
Published: November 2018

Background & Objective: Alzheimer’s disease (AD) and Parkinson’s disease (PD) affect an
increasing number of the elderly population worldwide. The existing treatments mainly improve the
core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring
flavonoids are well-documented for neuroprotective and neurorestorative effects against various
neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products
flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the
underlying mechanisms.

Conclusion:

This review provides valuable clues for the development of novel therapeutics against
neurodegenerative diseases.
Different Food Odors Control Brain Connectivity in Impulsive Children
Authors: de Celis-Alonso Benito , Hidalgo-Tobón Silvia S. , Barragán-Pérez Eduardo , Castro-Sierra Eduardo , Dies-Suárez Pilar , Garcia Julio , Moreno-Barbosa Eduardo , Arias-Carrión Oscar
Published: November 2018

Background:

Impulsivity is a complex multi-dimensional combination of behaviors which include: ineffective impulse control, premature decision-making and inability to delay gratification.

Objective:

The aim of this work was to explore how food odor perception and its emotional value is affected in impulsive children.

Methods:

Here we compared two cohorts of impulsive and control children with ages between 10 and 16 years. Both groups underwent a functional magnetic resonance imaging experiment, in which foodrelated odor-cues were presented to all of them.

Results:

Differences in regions of blood oxygen level dependent activation, as well as connectivity, were calculated. Activations were significant for all odors in the impulsive group in the temporal lobe, cerebellum, supplementary motor area, frontal cortex, medial cingulate cortex, insula, precuneus, precentral, para-hippocampal and calcarine cortices.

Conclusion:

Connectivity results showed that the expected emotional reward, based on odor perceived and processed in temporal lobes, was the main cue driving responses of impulsive children. This was followed by self-consciousness, the sensation of interaction with the surroundings and feelings of comfort and happiness, modulated by the precuneus together with somatosensory cortex and cingulum. Furthermore, reduced connectivity to frontal areas as well as to other sensory integration areas (piriform cortex), combined to show different sensory processing strategies for olfactory emotional cues in impulsive children. Finally, we hypothesize that the cerebellum plays a pivotal role in modulating decision-making for impulsive children.
Exosomal miR-214-5p Released from Glioblastoma Cells Modulates Inflammatory Response of Microglia after Lipopolysaccharide Stimulation through Targeting CXCR5
Authors: Yang Jian-kai , Liu Hong-jiang , Wang Yuanyu , Li Chen , Yang Ji-peng , Yang Liang , Qi Xue-jiao , Zhao Yin-long , Shi Xue-fang , Li Jing-chen , Sun Guo-zhu , Jiao Bao-hua
Published: November 2018

Background and Objective: Exosomes communicate inter-cellularly and miRNAs play critical roles in this scenario. MiR-214-5p was implicated in multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved in glioblastoma, especially via exosomal pathway, is still elusive. Here we sought to comprehensively address the critical role of exosomal miR-214-5p in glioblastoma (GBM) microenvironment.

Methods:

The relative expression of miR-214-5p was determined by real-time PCR. Cell viability and migration were measured by MTT and transwell chamber assays, respectively. The secretory cytokines were measured with ELISA kits. The regulatory effect of miR-214-5p on CXCR5 expression was interrogated by luciferase reporter assay. Protein level was analyzed by Western blot.

Results:

We demonstrated that miR-214-5p was aberrantly overexpressed in GBM and associated with poorer clinical prognosis. High level of miR-214-5p significantly contributed to cell proliferation and migration. GBM-derived exosomal miR-214-5p promoted inflammatory response in primary microglia upon lipopolysaccharide challenge. We further identified CXCR5 as the direct target of miR-214- 5p in this setting.

Conclusion:

Overexpression of miR-214-5p in GBM modulated the inflammatory response in microglia via exosomal transfer.