bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-toxigenic Vibrio cholerae – just another cause of vibriosis or a potential new pandemic?
Authors:   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Dr. Victor Babeș Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania, Gherlan George Sebastian , Lazar Dragos Stefan ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Dr. Victor Babeș Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania, Florescu Simin Aysel ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Dr. Victor Babeș Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania
Published: February 2025

Although nontoxigenic Vibrio cholerae usually stands in the shadow of the two serogroups (O1 and O139) that cause pandemic cholera, its role in human pathology is increasingly recognized and described in the literature. The habitat of these pathogens is brackish seawater or even freshwater, and the infections caused by them include contact with these waters or consumption of seafood originating in this habitat, which is constantly expanding because of global warming. This habitat extension is a typical example of climate change's impact on infectious diseases. Although nontoxigenic Vibrio cholerae strains are rarely capable of producing the classical cholera toxin, they possess many other virulence factors, can secrete various other toxins, and thus produce illnesses that are sometimes even severe or life-threatening, more frequently in immunocompromised patients. Vibriosis may manifest as gastrointestinal illnesses, wounds, skin or subcutaneous tissue infections, or septicemia. To establish the correct etiological diagnosis for these infections, a high index of suspicion must be maintained, as the diagnostic techniques require targeted investigations and specific collection and transportation of the samples. Empiric treatment recommendations are available, but owing to the increasing resistance of this pathogen, susceptibility testing is needed for every diagnosed case. We intend to raise awareness regarding these infections, as they tend to be more frequent than they were in the past and to appear in areas where they had not been recognized before.
Pembrolizumab-induced simultaneous and multiple immune-related adverse events including myasthenia gravis, myositis, hepatitis, and pityriasis lichenoides in a non-small cell lung cancer patient
Authors:   Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea, Han Mi-ran , Lee Chang-Hoon ,   Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea, Jeon So-Yeon ,   Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea
Published: February 2025

Pembrolizumab, an immune checkpoint inhibitor (ICI) targeting the programmed cell death protein 1 (PD-1) receptor on T cells, enhances the immune system’s ability to recognize and attack cancer cells. However, immune-related adverse events (irAEs) may arise, necessitating careful monitoring during treatment. Here, we present the case of a 47-year-old woman who developed multiple irAEs following pembrolizumab therapy. Initially diagnosed with Stage IIIB non-small cell lung cancer, she underwent chemotherapy followed by concurrent chemoradiotherapy. After two years of monitoring, progression of disease was observed, and pembrolizumab was initiated as second-line chemotherapy. Shortly thereafter, she presented with left-sided ptosis and weakness in both upper and lower extremities. Diagnostic evaluation, including a tensilon test and laboratory findings, confirmed with myositis, hepatitis, and myasthenia gravis. Treatment with steroids and neostigmine led to marked clinical improvement. Two months later, the patient developed additional dermatological symptoms, including rash and pruritus. Skin biopsy confirmed a diagnosis of pityriasis lichenoides. she is currently receiving antihistamines therapy, with no further exacerbation. This case underscores the importance of recognizing and promptly managing irAEs associated with ICIs to ensure patient safety and treatment efficacy.
Botulinum toxin-a therapy in pediatric population - single-center experience
Authors: Ostoic Marijana , Milenkovic Marina , Zivkovic Dragana
Published: February 2025

Introduction. This study aims to evaluate the efficacy and safety of
Botulinum toxin-A therapy in pediatric population with lower urinary tract
symptoms. Material and Methods. A retrospective review was conducted on our
initial clinical experience in treating lower urinary tract symptoms with
Botulinum toxin-A at the Institute for Child and Youth Health Care of
Vojvodina. Given the diversity of symptoms and the heterogeneity of
underlying pathological conditions, each patient and their treatment
outcomes were individually analyzed. Results. Our clinical experience
revealed that 80% of the patients demonstrated significant improvement in
symptoms following Botulinum toxin-A injections. Specifically, of the 17
patients treated, 15 reported symptom relief, with 7 achieving complete
regression of lower urinary tract symptoms. Only two patients with
developmental delays exhibited partial improvement, with persistent lower
urinary tract symptoms. Conclusion. Botulinum toxin-A injections have shown
promising efficacy in managing refractory bladder dysfunction in the
pediatric population. The majority of patients experienced symptom
regression, with many achieving complete remission. The treatment protocol
was well-tolerated, with no adverse effects observed. However, the
variability in treatment responses, particularly in patients with
developmental delays, underscores the need for individualized treatment
planning. Larger cohort studies with extended follow-up periods are needed
to validate the longterm efficacy and safety of Botulinum toxin-A therapy in
pediatric population. Among available therapeutic options, Botulinum toxin-A
plays a significant role in improving the quality of life for children with
lower urinary tract symptoms.
Differences in hemodynamic parameters in general and spinal anesthesia during lower limb orthopedic surgeries
Authors: Svedic Nadja , Maricic-Prijic Sanja , Tatic Milanka , Popovic Radmila , Bajur Stefan
Published: February 2025

Introduction. Hemodynamic instability is ? frequent adverse effect during
anesthesia and one of the significant parameters in determining the type of
anesthesia. This study examined the incidence of hypotension and bradycardia
during general and spinal anesthesia in hip and knee arthroplasty, alongside
potential causes. We hypothesized that hypotension occurs more frequently
with general anesthesia, while bradycardia is more prevalent with spinal
anesthesia. Material and Methods. This retrospective study included patients
who underwent total hip or knee alloarthroplasty. Data regarding blood
pressure, heart rate, long-term antihypertensive therapy, and comorbidities
were extracted from medical records. Patients were divided into two groups
based on the type of anesthesia administered: general or spinal anesthesia.
Results. Among 371 patients, 105 experienced bradycardia, and 308 developed
hypotension based on systolic blood pressure measurements. Hypotension was
significantly more common in patients receiving general anesthesia, with the
lowest mean arterial blood pressure observed in 41 patients (59.4%).
However, there was no significant difference in the incidence of bradycardia
between spinal and general anesthesia. Similarly, no significant differences
were identified in the incidence of hypotension and bradycardia between
standard or unilateral spinal anesthesia. Chronic essential hypertension was
associated with occurrence higher incidence of bradycardia (86.7%).
Additionally, antihypertensive therapy was linked to increased occurrences
of both hypotension (134 patients, 43.5%) and bradycardia (74 patients,
70.5%). Discussion/Conclusion. Intraoperative hypotension is more prevalent
in patients undergoing general anesthesia. However, no significant
difference in the occurrence of bradycardia was observed between general and
spinal anesthesia. Essential hypertension and long-term antihypertensive
therapy are potential risk factors for bradycardia and hypotension during
anesthesia.
Contemporary methods of the improvement of resin-dentin bonds: A literature review
Authors: Beljanski Isidora , Lainovic Tijana , Maravic Tatjana , Blazic Larisa
Published: February 2025

Introduction. Despite significant advancements in materials for permanent
restorations, there is still no material that fully replicates the physical,
chemical, and biological properties of dental tissues. Contemporary research
in adhesive dentistry focuses on achieving a reliable and durable bond
between restorative materials and dental substrates. This paper aims to
present recent innovations in dental technology focused on improving the
challenging bond between restorative materials and dentin. Currently,
several key strategies address this issue, including the application of
collagen cross-linkers, antioxidants, inhibitors of endogenous proteinases,
reinforcement with inorganic fillers and remineralization agents,
modifications in bonding techniques, and substrate treatment using lasers.
Conclusion. Current knowledge and experimental findings suggest that modern
methods of modifying the dentin substrate can achieve a satisfactory initial
adhesive bond. However, the degradation of the interfacial contact surface
remains a significant challenge, compromising the long-term durability of
restorations.
Multi-organ complications associated with adult varicella zoster virus infection: Case report
Authors: Mutibaric Karla , Djuric Aleksandar , Djuric Mirna
Published: February 2025

Introduction. The varicella-zoster virus is the causative agent of
chickenpox, a disease that predominantly affects the pediatric population.
Although the condition typically follows a benign course, it can lead to
prolonged and multisystem involvement in both immunocompromised and
immunocompetent, adults. This paper aims to present a case of an adult
patient with pneumonia, pulmonary embolism, antiphospholipid syndrome, liver
lesions, and thrombocytopenia following exposure to the virus, highlighting
the increased risk of complications in adulthood. Case Report. A 25-year-old
female was admitted to the Institute for Pulmonary Diseases of Vojvodina
with fever, fatigue, malaise, and the onset of exanthema accompanied by
dyspnea. The patient had no history of chronic diseases but was previously
hospitalized during pregnancy due to eclampsia. Clinical findings and
serological analyses confirmed a primary varicella-zoster virus infection.
Chest radiography revealed pathognomonic bilateral nodular pneumonia,
warranting further radiological evaluation due to the severity of the
findings. Elevated D-dimer levels raised suspicion of pulmonary embolism,
which was subsequently confirmed through computed tomography pulmonary
angiography. While adult age and history of smoking were identified as risk
factors, the extent of the clinical findings prompted immunological testing,
leading to a diagnosis of antiphospholipid syndrome. Conclusion. This case
underscores the importance of early recognition and comprehensive management
of varicellazoster pneumonia. A multidisciplinary approach is essential to
ensure favorable outcomes in patients with severe complications.
Digital Detectives: The Intersection of Artificial Intelligence and Signature Forgery Detection
Authors: S Sinha , A Kapoor
Published: February 2025

Signatures are the most socially accepted behavioral biometric trait which is widely used as a means of personal identification
routine transactions. Signatures peculiarly represent an individual due to the presence of certain class and individual
characteristics which are subconsciously accommodated within a person and become one of his normal habits with the
passage of time. This signature when replicated, results in intersection of two different individual characteristics with traces
of replication, which on close examination can be detected by an experienced forensic document examination expert. This
paper represents a comparative study for detection of forgery between the document expert’s opinion and role of Artificial
Intelligence in it. It has been concluded that in order to increase the value of evidence in the court of law, the expert’s opinion
should be supported with the results derived from automated methods, so that objectivity can be applied to this subjective
area of document examination which is majorly based on the observation skills and the experience of an expert, where the
opinion of different experts can vary
USO DE FOSFORITOS DO GRUPO BAMBUÍ COMO REMINERALIZADORES E ANÁLISE DOS SEUS BENEFICIOS SOCIO-AMBIENTAIS
Authors: Silveira Rafael Toscani Gomes da , Campos Jose Eloi Guimaraes , Matos Debora Rabelo
Published: February 2025

O presente estudo avaliou a eficácia do uso de pó de rocha como remineralizador do solo, com foco em suas interações no desenvolvimento vegetal, análise mineralógica e seus benefícios ambientais e sociais. Experimentos foram conduzidos em áreas de latossolo vermelho, fertilizadas com diferentes teores de fosforito. Os resultados demonstraram que as áreas fertilizadas apresentaram melhor desenvolvimento vegetativo e maior área foliar em comparação às porções não fertilizadas. Análises de raios-X revelaram a formação de minerais ricos em nutrientes essenciais, como ilita, montmorilonita, carbonatofluorapatita e carbonatohidroxiapatita, que fornecem potássio, fósforo, cálcio e magnésio para o solo. Os benefícios da remineralização vão além do aumento da fertilidade do solo, englobando a sustentabilidade ambiental e a redução da dependência de fertilizantes importados. A prática promove o aproveitamento de rejeitos minerais, incentiva a agricultura de base agroecológica e pode minimizar os impactos sociais causados pela indústria de fertilizantes. Em um cenário de crescente preocupação com a segurança alimentar e sustentabilidade, o pó de rocha surge como uma alternativa promissora, especialmente para países com solos pobres, como o Brasil.
A LEI COMPLEMENTAR N° 214/2025 E A IMUNIDADE DOS TEMPLOS DE QUAISQUER CULTOS
Authors: Sarno Antonio Leandro Fagundes , Fontenele-Gomes Luziêt Maria
Published: February 2025

A Lei Complementar n° 214/2025, promulgada em 16 de janeiro de 2025, instituiu o Imposto sobre Bens e Serviços (IBS), a Contribuição Social sobre Bens e Serviços (CBS) e o Imposto Seletivo (IS), promovendo uma reforma significativa no sistema tributário brasileiro, com foco na simplificação e transparência da arrecadação. A Lei estabelece imunidades tributárias para entidades religiosas e templos de quaisquer cultos, incluindo suas organizações assistenciais e beneficentes. No entanto, a definição de templo como pessoa jurídica de direito privado sem fins lucrativos pode gerar controvérsias, especialmente em relação às comunidades religiosas de matriz africana que, muitas vezes, funcionam em estruturas familiares e comunitárias, sem formalização jurídica. Este artigo analisa os possíveis conflitos entre a nova legislação e a Constituição Federal de 1988, que não exige formalização jurídica para a concessão de imunidades tributárias a templos religiosos. Conclui-se que a exigência de formalização jurídica deve aplicar-se apenas aos templos que realizam atividades econômicas, enquanto os demais devem gozar de imunidade independentemente de formalização, conforme previsto na Constituição.
From passive to critical consumption: The role of educational content in short videos to improve students' critical thinking skills
Authors: Aspar Fathir , Refdinal Refdinal , Erizon Nelvi , Jasman Jasman , Irzal Irzal , A Yufrizal
Published: February 2025

The engaging and personalized nature from short video makes it quickly popular, yet concerns persist about their potential to diminish critical thinking skills. This study investigates whether short videos with educational content can improve students' critical thinking skills. Using a quasi-experiment method, Thirty-three participants were divided into control and experimental groups, with critical thinking measured using the Holistic Critical Thinking Scoring Rubric (HCTSR) based on essay analysis in pretest and posttest. After administering educational short videos to the experimental group, the results showed that there was an increase in students' critical thinking skills, shown by the result of controlling the pretest variable through the ANCOVA test with a p-value of <0.001. The result highlights the potential of educational short videos as tools for fostering critical thinking by providing interventions which prioritize treatment fidelity through standardized protocols (SOPs) for content delivery, validating assessment tools, and structuring content design. Recommendations for future research include larger sample sizes, repeated data collection at strategic intervals, and rigorous validation of question complexity.
Attitude and its relationship toward information and communication technology competency among vocational engineering students
Authors: Rinaldi Rinaldi , Sari Putri Gemala , Hamzah Mohd Isa , Alimin Masnaini
Published: February 2025

There are gaps between vocational engineering curricula and industry competency needs, especially in information and communication technology (ICT) competency. However, limited studies have been conducted on factors affecting ICT competency among vocational engineering students, particularly attitudes toward ICT utilization. Thus, this study aims to determine the attitude and the relationship toward ICT competency among vocational engineering students based on the Unified Theory of Acceptance and Use of Technology II (UTAUT II). It was conducted in Higher Education Institutions in West Sumatera, Indonesia. It was a survey study with a quantitative method that used one set of questionnaires to collect data. Respondents are 805, covering first-year and last-year students enrolled in those institutions by purposive sampling. Data were analyzed descriptively for mean and standard deviation, and inferentially by employing Pearson Correlation. Findings showed that the ICT competency among vocational engineering students was lower than their attitude toward ICT utilization. A high attitude only is not enough to support the competency. Thus, this study can be used as a guide by the relevant authorities such as the Ministry of Education Affairs to take action to enhance the ICT competency among vocational engineering students from other aspects.
The Meaning of Money and Its Influence on Decision To Take A Loan: Study on Members of Credit Union
Authors: Hartanti Fransisca Emi , Kusumajati Titus Odong
Published: February 2025

Purpose: This study aims to elaborate on how credit union members perceive money and how these perceptions inform the decision made before applying for a loan from a credit union.
Method: The study employed grounded theory as its methodology. Data were obtained from in-depth, semi-structured interviews and observations involving ten members of a credit union in Indonesia. This research's respondents are divided into two types: the first lists respondents who actively borrow (five respondents), and the second lists those who do not (five respondents).
Result: The study shows two categories in which money is perceived: money as a resource and money as a source of emotions. The study further found that six key factors inform the decision to apply for a loan. Past experiences (1) contribute to the meaning of money (2) and perceptions toward loans (3). Further, pressing needs (4) not accompanied by financial strength (5) to finance them result in motives for procuring loans. With access to loans (6), motives can turn into an action of taking out a loan. Based on the findings, Credit unions should perform a thorough analysis to identify pressing needs among their members and evaluate the access to loans regarding their capacity to fulfill the members' needs. Furthermore, loans should be conveyed as a means to achieve financial goals and improve the members' quality of life.
Perbandingan Hukum “Right to be Forgotten” Terkait Penyalahgunaan Data Pribadi di Turki dan Indonesia
Authors: Puspita Bernadita Gea
Published: February 2025

Perkembangan digital saat ini membuat ketersediaan informasi di internet menjadi abadi/permanen, serta berpotensial disalahgunakan dengan cara dipublikasikan atau dibuat tanpa sepengetahuan dan izin dari pemilik data. Tujuan dilakukan penelitian ini adalah untuk mengetahui perbandingan hukum kedua negara serta kontribusi pengaturan right to be forgotten di negara Turki bagi negara Indonesia. Metode pendekatan yang digunakan dalam penelitian ini yaitu yuridis normatif dan yuridis komparatif. Spesifikasi penelitian pada penelitian ini yaitu deskriptif analisis. Objek penelitian pada penelitian ini yaitu hukum mengenai right to be forgotten di Turki dan Indonesia. Data yang digunakan yaitu data sekunder yang terdiri dari bahan hukum primer yakni peraturan perundang-undangan, dan bahan hukum sekunder berupa buku, dan jurnal-jurnal yang berkaitan dengan penelitian ini, dan juga wawancara. Teknik pengolahan dan penyajian data pada penelitian ini yaitu teks naratif, serta metode analisa data yang digunakan yaitu metode kualitatif. Terdapat beberapa hal perbedaan antara kedua negara, namun terdapat juga persamaan yang bisa dilihat yaitu kedua negara sama-sama tidak menyebutkan secara definisi mengenai apa itu right to be forgotten pada peraturan perundangan-undangan mereka. Ius constituendum bagi Indonesia yaitu membentuk badan/lembaga independen yang mengurusi hal-hal yang berkaitan dengan data pribadi.
Decàleg per a una narrativa alternativa sobre les migracions
Authors:   Investigadora sènior, CIDOB, Garcés Blanca
Published: February 2025

Com parlar d'immigració en un context de creixent polarització? Què dir per evitar que els postulats de l'extrema dreta s'apropiïn del discurs? Com anar més enllà dels arguments purament reactius? Com explicar la complexitat sense perdre's pel camí?

A manera de decàleg, a partir de deu afirmacions, aquesta Nota Internacional aborda totes aquestes qüestions. No ofereix receptes, però sí recull reflexions, assenyala dilemes i apunta a possibles alternatives. Tot això amb l'objectiu de pensar conjuntament una qüestió tan fonamental –per a tots i per a les nostres democràcies– com la forma en què volem seguir parlant sobre immigració.
Analysis of wavelet transform application in aircraft longitudinal motion identification
Authors: Modzelewski Michał , Lichota Piotr
Published: February 2025

This study investigates the application of wavelet transforms in identifying aircraft longitudinal motion dynamics. The Output Error Method, enhanced with wavelet transforms, specifically Haar wavelets at varying decomposition levels, was used to estimate system parameters. The impact of filtering wavelet coefficients and the use of a coherence function in determining parameter changes were analyzed to assess their effect on model identification accuracy. The identification process involved estimating the parameters of a linear model by fitting its responses to those of a nonlinear system, which were noise-perturbed and treated as measurement data. The results demonstrate the successful application of wavelet transforms in system identification for flying objects, with recommendations for further optimization.
The Influence of the Amplitude Spectrum Correction in the HFCC Parametrization on the Quality of Speech Signal Frame Classification
Authors: Gmyrek Stanislaw , Hossa Robert , Makowski Ryszard
Published: February 2025

The voiced parts of the speech signal are shaped by glottal pulse excitation, the vocal tract, and the speaker’s lips. Semantic information contained in speech is shaped mainly by the vocal tract. Unfortunately, the quasiperiodicity of the glottal excitation, in the case of the HFCC parameterization, is one of the factors affecting the significant scatter of the feature vector values by introducing ripples into the amplitude spectrum. This paper proposes a method to reduce the effect of quasiperiodicity of the excitation on the feature vector. For this purpose, blind deconvolution was used to determine the vocal tract transfer function estimator and the corrective function of the amplitude spectrum. Subsequently, on the basis of the obtained HFCC parameters, statistical models of individual Polish speech phonemes were developed in the form of mixtures of Gaussian distributions, and the influence of the correction on the quality of classification of speech frames containing Polish vowels was considered in details. The aim of the introduced solution was to narrow the GMM distributions, which clearly, according to the detection theory, reduces classification errors. The results obtained confirm the effectiveness of the proposed method.
The Blue Light LASER technology: a new progress in ENT surgery
Authors: Palaghia Sandra-Maria , Georgescu Stefania-Iuliana , Sarafoleanu Codrut
Published: February 2025

The advent of Blue LASER technology in otorhinolaryngology has transformed the management of various ear, nose and throat (ENT) disorders. Its distinct wavelength (445 nm) offers superior tissue selectivity, minimizing collateral damage and optimizing surgical outcomes compared to traditional LASERs. Blue Light LASER’s ability to target haemoglobin and melanin reduces intraoperative bleeding, scarring, and thermal damage. Its precision and versatility make it a valuable tool in addressing complex ENT pathologies. However, limitations, such as shallow penetration and potential risks of thermal damage, necessitate careful application. While it requires specialized training and consideration of its limitations, its benefits in reducing complications and improving recovery times highlight its potential in modern surgical practices. The article aims to analyse the key characteristics of Blue LASER in ENT pathology, presenting also a case of a 57-year-old male with lingual tonsil hypertrophy and obstructive sleep apnea who underwent Blue LASER surgery for tongue base reduction.

CONCLUSION. Blue LASER technology ushers in a new era in ENT surgery. However, a thorough evaluation of its benefits and limitations is crucial to fully harness its potential in clinical applications.
Beyond the horizontal – impact of body position on nasal dynamics: insights from 4-phase positional rhinomanometry
Authors: Moideen Sanu P , Sistla Srinivas Kishore , Noorjehan Sabu Abdul Hameed , Sheriff Razal Mohammed , Samad Subina Beegum
Published: February 2025

BACKGROUND. Positive posture reaction is a common concern in obstructive sleep apnea (OSA) patients, which affects both their sleep quality and overall health-related quality of life. Rhinomanometry has been used as a functional test to assess nasal airway resistance (NAR) and measure nasal airflow (NAF).

OBJECTIVE. We conducted this study using 4-phase positional rhinomanometry (4PPR) to investigate potential correlations between NAR and NAF when comparing the sitting and supine positions through the use of 4PPR.

MATERIAL AND METHODS. This cross-sectional study involved a consecutive group of adult patients (n=115) diagnosed with OSA, aged 18 to 60 years. 4PPR evaluation was conducted in accordance with consensus guidelines. The assessments were carried out in both the sitting position and after 10 minutes in the supine position. Correlation and comparative analyses were conducted using Pearson correlation, Spear-man rank correlation, paired t-tests, and the Kruskal-Wallis test.

RESULTS. A statistically significant increase in total NAR (mean difference: +0.09 Pa/cm³/sec, p=0.048) and a significant decrease in total NAF (mean difference: -52.1 mL/sec, p=0.001) were observed during the transition from sitting to supine. Subgroup analysis revealed a significant rise in NAR for the right nasal cavity (p=0.0001), while the left side showed a non-significant increase (p=0.114). Both nostrils showed significant reductions in NAF (right: p=0.001, left: p=0.000). Classification of nasal obstruction based on sitting NAR and NAF indicated that patients with higher baseline NAR showed greater sensitivity to positional changes (Spearman’s ρ = -0.42, p<0.001). Conversely, changes in NAF were less dependent on baseline airflow (ρ = -0.15, p=0.12), suggesting alternative influencing factors.

CONCLUSION. From our observations, it is clearly evident that the total nasal airway resistance increases, and the nasal airflow reduces on lying down, the primary source of variation being the posture changing. This finding is valuable in snorers and sleep apnea patients. 4-phase positional rhinomanometry should be performed to diagnose upper airway collapse in the supine position as part of the OSA evaluation.
Addressing the Paradox of Rest with Innovative Technologies
Authors: PIŠOT Rado , MARUŠIČ Uroš , ŠLOSAR Luka
Published: February 2025

The paradox of rest lies in its dual nature: essential for recovery yet potentially harmful when prolonged. Prolonged physical inactivity (PI) significantly contributes to non-communicable diseases (NCDs). Studies show nearly a third of adults worldwide were insufficiently active in 2022, with the economic costs of PI projected to reach INT$520 billion by 2030.

Bedrest models have illuminated the rapid onset of insulin resistance, general functional decline and muscle atrophy associated with PI, particularly in hospitalised older adults. Innovative technologies, such as extended reality (XR), offer promising solutions for mitigating the effects of PI and can enhance non-physical rehabilitation techniques such as motor imagery and action observation. These technologies provide immersive, personalised therapeutic experiences that engage multiple senses, transforming passive recovery into an active process and addressing both the physical and cognitive consequences of inactivity.

Results of bedrest study showed significant preservation of muscle mass, improved strength and enhanced insulin sensitivity in the intervention group compared to controls. These findings highlight the potential of XR-based strategies in addressing structural and functional declines during inactivity. As part of the Interreg VI-A Italia-Slovenija project X-BRAIN.net, advanced XR-equipped active rooms were developed to aid post-stroke rehabilitation in acute care settings. XR technologies, particularly VR, have shown promise in providing dynamic and adaptable therapeutic environments that facilitate early and targeted interventions. Future advancements focus on integrating XR with brain-computer interfaces (BCIs) and synchronised visual-haptic neurofeedback, enhancing sensorimotor cortical activation and improving rehabilitation outcomes. Comprehensive multimodal approaches, including nutritional, physical and non-physical interventions, are emerging as effective strategies to personalise and optimise patient recovery.
The Effectiveness of Intervention to Reduce Blood-Borne Pathogen Exposure Incidents in Healthcare Workers in the Largest Clinical Setting in Slovenia
Authors: ŠESTAN Nevenka , ZALETEL-KRAGELJ Lijana , FRANKO Alenka
Published: February 2025

Aim

Aimed at evaluating the effectiveness of intensified organised training programmes introduced in 2016 and 2017 for raising awareness of the problem of blood-borne incidents (BBIs), the objective was to analyse the incidence of reported BBIs (RBBI) over a 15-year period in different groups of healthcare workers (HCWs) employed at the University Medical Centre in Ljubljana (UMCL).

Methods

All UMCL incidents that occurred and were reported from 1 January 2008 to 31 December 2022 were included in the study. The entire period was divided into two observation periods, 2008-2017 and 2017-2022. For testing a linear trend, whenever applicable a piecewise/segmented linear regression was applied, with the year 2017 as a break-point.

Results

In the 2008-2017 period, the trend of annual incidence risk was mostly on the increase. The increase was statistically significant in medical doctors (MDs) and dental medicine doctors (DMDs) (p<0.001) as well as in other occupational groups (p=0.015). In the 2017-2022 period, the decrease was statistically significant in females (p=0.011), in MDs and DMDs (p=0.007), in nurses (p=0.021) and in HCWs in the Surgery Division (p=0.023).

Conclusion

The results of the present study suggest that measures introduced in the UMCL were partially effective. The findings could serve as a basis for the development of improved programmes for better prevention, reporting and reducing the consequences of blood-borne pathogen exposure incidents among HCWs not only in Slovenia, but also worldwide.
Deutsches Exportmodell unter Druck – eine Analyse der Exportentwicklung nach 2015
Authors: Matthes Jürgen , Sultan Samina
Published: February 2025

Exports, traditionally a strong engine of growth for the German economy, have started to stutter. This article demonstrates that export performance on German sales markets continued to decline even after 2015. It also analyses the target countries and product groups where particular export weaknesses can be identified and the possible causes. Overall, it becomes clear that there are losses precisely where there were previously strengths. There is also evidence of protectionism and the effects of geopolitical conflicts. But above all, the erosion of German competitiveness seems to be playing a role, which emphasises the urgency for economic policy reforms.
Arbeitszeit und Arbeitsumfeld – Indikatoren, Entwicklungen und Bewertung
Authors: Hübler Olaf
Published: February 2025

The demand for a work-life balance and the noticeable labour shortage have intensified the public debate on changes to working hours. Can society afford a general reduction in working hours or are longer working hours necessary? The assessment should not be based solely on the agreed reduction or extension of weekly working hours. The effective working time effects of various measures must be analysed. Possible adjustments for changes result from an analysis of the effects on work intensity and the number of employees. Changes in sick leave and the number of vacation days as well as adjustments in full-time and part-time employment are significant, as is the case with the effective retirement age.
PENGARUH PELATIHAN DAN PENGEMBANGAN KARIER TERHADAP PRODUKTIVITAS KERJA PEGAWAI MELALUI VARIABEL MEDIASI MOTIVASI
Authors: Ariyanarti Ria Dwi , Rosidi Rosidi , Muda Navi
Published: February 2025

Reformasi terhadap kualitas pegawai (sumber daya manusia) merupakan bagian dari reformasi pemerintahan dalam rangka mengarah pada pencapaian good governance. Upaya yang dapat dilakukan melalui sistem manajemen kinerja, yang tidak hanya pada staf akan tetapi menyeluruh dari pegawai jajaran kepemimpinan sampai dengan pegawai pada tingkat operasional. Tujuan penelitian ini untuk menganalisis pengaruh langsung dan tidak langsung pelatihan dan pengembangan karir terhadap produktivitas kerja melalui motivasi sebagai variabel mediasi pada pegawai Dinas Kependudukan dan Pencatatan Sipil Kabupaten Mojokerto. Metode penelitian ini menggunakan jenis kuantitatif eksplanatory. Responden dalam penelitian ini adalah semua pegawai yang berjumlah 52 di ambil secara sensus/ sampling jenuh, menggunakan Analisis statistik yaitu SEM-PLS. Hasil penelitian menunjukkan bahwa pelatihan tidak pengaruh terhadap motivasi, pengembangan karir berpengaruh terhadap motivasi, motivasi dan pengembangan karir berpengaruh terhadap produktivitas kerja, pelatihan tidak berpengaruh terhadap produktivitas kerja, motivasi tidak dapat memediasi pengaruh pelatihan terhasap produktivitas kerja, dan motivasi dapat memediasi pengaruh pengembangan karir terhadap produktivitas kerja.
THE IMPACT OF IJEPA POLICY ON THE VOLUME OF INDONESIAN BANANA EXPORTS TO JAPAN
Authors: Bimantara I Kadek Rizky , Ayuningsasi A.A. Ketut
Published: February 2025

Economic relations between countries are an important factor that influences the economic development of each country. The potential country for Indonesia's banana exports is Japan. In order to facilitate international trade, an international trade agreement was made between Indonesia and Japan known as the Indonesia-Japan Economic Partnership Agreement (IJEPA). This research was conducted in Indonesia and Japan with a total of 29 years of observations obtained from secondary data, namely the Central Statistics Agency, UN Comtrade, and the World Bank. This study used linear regression analysis to determine the relationship between variables and was supported by SPSS applications. The results showed that Indonesia's banana production and IJEPA policy partially had a positive and significant effect, then the dollar exchange rate partially had a negative and significant effect, while Japan's GDP did not have a significant effect on Indonesia's banana export volume. Based on the results obtained, the government is expected to multiply similar agreements and improve regulations that can hinder the pace of exports. In addition, the government and stakeholders are expected to provide support facilities to exporters, which can later help improve Indonesia's export performance.
Konsep Desain Taman Ramah Anak Di Taman Janggan Kota Denpasar
Authors: Puspayanti Ayu Kade Puri , Semarajaya Cokorda Gede Alit , Sutari Ni Wayan Sri
Published: February 2025

Concept Design of Child Friendly Garden in Taman Janggan Denpasar City. Taman Janggan is one of the Child Friendly City programs which developed by government with an area of ??3,385 m2 located in the Renon Denpasar. This park has a land area of ??1,723 m2  which is not organized yet and enable for further development. This research aims to produce a child friendly garden concept design that can support recreational activities. The method used in this research is a survey method with data collection techniques include observation, interviews, and literature study. The research carried out by the stages consisted inventory, analysis, synthesis, concept development, and concept design. The research results are obtained an site plan, section, and perspective illustrations. The “agricurricular” concept is an illustration of child-friendly garden concept with an agriculture theme that paying attention to user needs and comfort through the softscape and hardscape arrangement of the garden.
Identifikasi Karakteristik Thermoscape Taman Kota Menggunakan Thermal Drone (Studi Kasus: Alun-alun dan Taman Heulang di Kota Bogor)
Authors: Pratiwi Neviera Khairunnisaa , Sulistyantara Bambang , Pratiwi Prita Indah
Published: February 2025

The existence of urban green open space is very important for the creation of a public space that can support various public activities of urban residents and become an ecological space for the creation of an adequate quality urban environment. Bogor City is one of the cities that is currently developing green open space in the form of an urban park to meet the needs of public space as a means of gathering and recreation. Thermal comfort is very important and must be considered in a green space. To obtain the thermal conditions of a landscape, this research uses a thermal drone. This study aims to identify the thermoscape characteristics of landscape elements and people's perceptions of it and also the correlations between them. The analysis used Agisoft Metashape, ArcMap 10.5, Google Earth Pro, Adobe Photoshop CS6, Microsoft Office 2019, and Image Color Summarizer online tool. The thermoscape results in the two urban parks are different due to differences in weather. However, the thermal conditions of each landscape elements are almost the same in both parks. Hardscapes in both parks can have a temperature of >40? C, while vegetation, especially trees, can have a temperature of <20? C. According to respondents, both parks are still considered warm based on their thermal sensation. Hot urban park areas can be modified by presenting a wider green space with good distribution and proportion to make it comfortable for the users.
Perencanaan Lanskap Saluran Irigasi “Tukad Tanah Putih” di Desa Adat Tegal Darmasaba, Kabupaten Badung sebagai Kawasan Rekreasi
Authors: Paradista Gusti Ayu Made Tasya , Asmiwyati I Gusti Agung Ayu Rai , Sudana I Putu
Published: February 2025

The development of river areas can be planned by utilizing the river as a recreation area. Planning development is carried out by utilizing the potentials that exist in the river area, one of the rivers that can be developed its potential is the Tukad Tanah Putih which is located and crosses Badung Regency, Bali. The Tukad Tanah Putih area is an area that is often visited by local people for recreational activities and daily activities, but current conditions are not good in structuring and developing the area such as the unavailability of facilities and infrastructure in the area resulting in damage to physical conditions that make not comfortable in the area for recreation. The Tukad Tanah Putih area is planned as a recreation area that is in harmony with nature and is able to accommodate the community for recreation, with planning space zoning in adapted to the results of regional analysis and synthesis. The research method has been carried out using a survey method with observation, documentation, interviews, and library studies with the stages of inventory, analysis, synthesis, and landscape planning with the aspects studied are biophysical and social aspects. Regional planning resulted in the division of zones, namely active recreation zone, passive recreation zone, and a visual zone, with conservation vegetation and aesthetic vegetation, and planned includes primary circulation and secondary circulation. The results of this study are in the form of recommendations for Tukad Tanah Putih as a recreation area with site plan and ilustrations for each area.
Dampak Perkembangan Pariwisata Terhadap Struktur Lanskap Di Kecamatan Kuta Selatan, Kabupaten Badung, Bali
Authors: Krisnandika Anak Agung Keswari , Yusiana Lury Sevita , Fitriana Devvy Alvionita
Published: February 2025

The Impact of Tourism Development on Landscape Structure in South Kuta District, Badung Regency, Bali. South Kuta District is one of the sub-districts in Badung Regency, Bali, which is located in a coastal area and is a tourism center. Its presence in a coastal area makes this subdistrict rich (ecosystem services) and vulnerable (change, damage and loss) simultaneously. As a tourism center, development in South Kuta District increases from year to year, especially in the tourist accommodation sector. This development development causes changes in the landscape structure. This research aims to analyze changes in landscape structure that occur and analyze the influence of tourism aspects on changes in landscape structure. The methods used in this research are spatial analysis, binary logistic regression analysis and SBE analysis. Spatial analysis is used to analyze landscape structure (patches) and its changes using Landsat 7 ETM+ imagery for 2010 and Landsat 8 OLI imagery for 2022. Binary logistic regression analysis to analyze the influence of tourism aspects on changes in landscape structure. The tourism aspect used is tourist accommodation data (lodging, restaurants, banking and health centers). Scenic Beauty Estimation (SBE) analysis is used as an assessment of areas experiencing changes in landscape structure. The urgency of this research is to prevent or minimize the impact of ecological damage from tourism development, especially the decline in environmental and visual quality due to changes in landscape structure that occur in South Kuta District.
Konsep Desain Taman Sekolah Dasar di Desa Pering dalam Akomodasi Psikomotorik Anak Usia Dini
Authors: Saputra Kadek Edi , Dharmadiatmika I Made Agus , Megisterina Megisterina
Published: February 2025

Elementary School Garden Design Concept in Pering Village in Accommodating Early Childhood Psychomotor Skills. The development of children's psychomotor skills is crucial to raising early childhood IQ. Many young children are restricted to indoor activities like playing with cellphones, sleeping, and other activities that don't require physical movement due to rapidly evolving technology and an unsupportive environment. By addressing these issues, researchers at Elementary School 5 Pering attempt to create aesthetically pleasing outdoor areas that enhance young children's psychomotor abilities. Through on-site case discussions and direct design proposals for research challenges and objectives, this study employs a qualitative research methodology. placing a strong emphasis on the spiritual and moral, physical, intellectual, emotional, and artistic facets of life. The fundamental idea or concept used in the design concept is active and continuous, which refers to the analysis and issues researched about the accommodation of early childhood psychomotor skills. Comprehensive concepts that are used to the design to promote early childhood psychomotor skills are filled with active and continuous elements. A site layout that accommodates the theme—active and continuous—is the study's end product.
The substantiation of the composition of an extemporaneous cream with antipsoriatic and anti-inflammatory effects
Authors: Polova Zh. М. , Butkevych Т. А. , Diachenko V. Yu. , Simonova O. A. , Oliinyk S. V.
Published: February 2025

Aim. To substantiate an extemporaneous emulsion cream based on purified naphthalan oil for the pharmacotherapy of psoriasis.
Materials and methods. Such methods as system analysis and generalization, as well as organoleptic, physicochemical, structural-mechanical, biopharmaceutical and statistical methods were used in the work.
Results. The composition of an extemporaneous agent in the form of a cream for external use with the antipsoriatic and anti-inflammatory action were substantiated. It contains a purified naphthalan oil, the chamomile oil extract and a 10 % oil solution of vitamin A as active components of the substance of natural origin. Six model samples of the emulsion cream were processed; Tween-80, emulsifier No. 1 and Olivem 1000 were introduced in them as emulsifiers. Glycerol and propylene glycol in the concentration of 10 % were used as structure-forming substances of the hydrophilic phase. Colloidal and thermal stability, pH, structural viscosity and kinetics of the active component release were determined by the agar diffusion method in order to substantiate the excipients in the composition of the emulsion cream.
Conclusions. As a result of the organoleptic, physicochemical, structural-mechanical and biopharmaceutical studies conducted, the composition of an extemporaneous emulsion cream with antipsoriatic and anti-inflammatory effects based on white purified naphthalan oil has been experimentally substantiated.
Geragogy in Healthcare: Enhancing Education for Older Adults and Professionals
Authors:   Winston-Salem State University, Jin Bora
Published: February 2025

The aging global population underscores the importance of adult education as a catalyst for promoting health and well-being among older adults and advancing professional practices in healthcare. This commentary examines the role of geragogy in addressing the unique learning needs of older adults,
New Differential Subordination and Superordination Results for a subclass of Meromorphic Univalent Functions Defined by a New Operator
Authors: Sabri Mustafa A. , Atshan Waggas Galib , El-Seidy Essam
Published: February 2025

In this paper, we explore and introduce a novel study employing a new operator denoted as W_(ν,γ,δ,τ,n,r,d)^(η,s)  within the field of geometric function theory, particularly in the context of sandwich theorems. We derive results pertaining to differential subordination and superordination for this new formula operator. Additionally, we establish specific sandwich theorems.