bluuebunny/crossref_metadata_2025 huggingface dataset:
Algebraic Multi-Layer Network: Key Concepts
Authors: Khanykov Igor , Nenashev Vadim , Kharinov Mikhail
Published: July 2023

The paper refers to interdisciplinary research in the areas of hierarchical cluster analysis of big data and ordering of primary data to detect objects in a color or in a grayscale image. To perform this on a limited domain of multidimensional data, an NP-hard problem of calculation of close to optimal piecewise constant data approximations with the smallest possible standard deviations or total squared errors (approximation errors) is solved. The solution is achieved by revisiting, modernizing, and combining classical Ward’s clustering, split/merge, and K-means methods. The concepts of objects, images, and their elements (superpixels) are formalized as structures that are distinguishable from each other. The results of structuring and ordering the image data are presented to the user in two ways, as tabulated approximations of the image showing the available object hierarchies. For not only theoretical reasoning, but also for practical implementation, reversible calculations with pixel sets are performed easily, as with individual pixels in terms of Sleator–Tarjan Dynamic trees and cyclic graphs forming an Algebraic Multi-Layer Network (AMN). The detailing of the latter significantly distinguishes this paper from our prior works. The establishment of the invariance of detected objects with respect to changing the context of the image and its transformation into grayscale is also new.
Prevalence of Histoplasma Antigenuria among Outpatient Cohort with Advanced HIV in Kampala, Uganda
Authors: Sekar Preethiya , Nalintya Elizabeth , Kwizera Richard , Mukashyaka Claudine , Niyonzima Godfrey , Namakula Loryndah Olive , Nerima Patricia , Fieberg Ann , Dai Biyue , Ellis Jayne , Boulware David R. , Meya David B. , Bahr Nathan C. , Rajasingham Radha
Published: July 2023

In sub-Saharan Africa, an estimated 25% of people with HIV present with advanced HIV and are at high risk of opportunistic infections. Whereas histoplasmosis has occasionally been seen in Uganda, the understanding of the local risk of acute infection is limited. We sought to determine the prevalence of Histoplasma antigenuria using an enzyme immunoassay (EIA, clarus Histoplasma GM EIA, IMMY; Norman, OK, USA) in a cohort of outpatients with advanced HIV disease in Kampala, Uganda. Among the persons with positive urine Histoplasma antigen tests, we assessed their clinical presentation and outcomes. The EIA was run on stored urine samples as per the manufacturer’s instructions. Specimens ≥1 EIA units were considered positive. Among the 388 tested urine samples, 4 (1.2%) were positive for Histoplasma antigen. The histoplasmosis prevalence among participants with a CD4 < 100 cells/mcL was 2.5% (4/158). Three of the four participants with a positive Histoplasma antigen test reported systemic symptoms consistent with histoplasmosis. All four participants had a positive urine lipoarabinomannan test and were treated for tuberculosis. By the four-week follow-up visit, all participants were clinically improved, alive, and in care without antifungal therapy. In advanced HIV, the clinical presentations of tuberculosis and histoplasmosis overlap. The value of histoplasmosis screening and pre-emptive treatment is an area of future research.
Adherence to Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Authors: Betancourt-Peña Jhonatan , Ávila-Valencia Juan Carlos , Rodríguez-Castro Jenifer
Published: July 2023

Background: Pulmonary rehabilitation (PR) allows for the treatment of patients with chronic obstructive pulmonary disease (COPD) as an intervention strategy that improves functional capacity, dyspnea, and health-related quality of life. However, adherence to such programs might be improved. This study aimed to describe the differences in sociodemographic and clinical variables, functional capacity, and health-related quality of life in patients diagnosed with COPD adherent and non-adherent to pulmonary rehabilitation at a clinic in Cali, Colombia. Methods: This study followed a descriptive cross-sectional model with 150 patients diagnosed with COPD. Adherence was classified by taking into account the number of sessions completed: low (<35%), moderate (35–85%), and high (>85%). Sociodemographic, clinical, functional capacity, and health-related quality of life variables were considered. Results: Adherence to the PR was rated as high in 57.3% of patients. Variables such as sex, health system affiliation, height, functional capacity, resting SaO2, and health-related quality of life presented significant differences (p-value ≤ 0.05). The main causes of non-adherence to the program were medical recommendations that prevented continuing in the program due to clinical and safety issues and economic issues that prevented reaching the rehabilitation site, as it was unaffordable. Conclusions: It can be concluded that adherence to pulmonary rehabilitation was rated as high in 57.3% of patients. The high adherence to the PR program occurred in male patients with a capacity to pay the Colombian health system (contributory regime).
Research Progress on the Dynamic Characteristics of Planetary Gear Transmission in a Non-Inertial System
Authors: Gao Bingwei , Wang Yongkang , Yu Guangbin
Published: July 2023

Planetary gear systems have many advantages over other gear systems. Previous studies on its dynamic characteristics mostly used Earth as the reference system, which is inconsistent with the actual working conditions of many planetary gear systems, such as aircraft maneuvering, vehicle movement changes, etc. By analyzing representative research papers, this study summarizes the lumped-parameter, finite element, and rigid–flexible coupling models commonly used in studying the traditional dynamic characteristics. Then, the research status of gear–rotor and planetary gear systems in inertial and non-inertial systems is summarized. The research progress of load characteristics, vibration characteristics, and vibration control of the traditional planetary gear system is summarized. Finally, some suggestions for future development are put forward. There are a few studies on the non-inertial dynamics of planetary gear systems. The three analysis models have distinct characteristics and applications but can all be used in non-inertial systems. The dynamic analysis method of non-inertial rotor systems can be combined with the dynamic study of gear systems. It is of practical significance to study the non-inertial dynamic characteristics of planetary gear systems. Scholars can refer to the non-inertial dynamic research of the gear–rotor system, select the analysis model according to the needs, and continue to study the dynamic characteristics of the planetary gear system under the non-inertial system.
Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis
Authors: Andrýsková Natália , Sourivong Paul , Babincová Melánia , Babinec Peter , Šimaljaková Mária
Published: July 2023

Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing dithranol photostability and remote-controlled drug delivery for psoriasis therapy. We have shown that coaxial nanofibers with titanium oxide nanoparticles (reflecting and absorbing ultra-violet light) in the PVA-based sheath part of the nanofibers can increase dithranol photostability. Incorporation of dithranol and magnetic nanoparticles into a PCL-based core of the nanofibers enables dithranol release control via an external radio-frequency field. The application of a radio-frequency field generates heat that can be used to control the release rate of drugs. Our approach therefore offers a non-invasive and remotely controlled drug release system that hold promise for the development of new topical formulations for psoriasis treatment using dithranol.
Mesenteric Ischemia in a Splenectomized Patient with Auto-Immune Hemolytic Anemia: Case Report
Authors: Vidal-Cañas Sinthia , Zuñiga-Jaramillo Cristian , Artunduaga-Cañas Esteban , Pérez-Garay Valentina , Liscano Yamil
Published: July 2023

Mesenteric ischemia is a serious complication that can occur after splenectomy for hemolytic anemia, potentially leading to lifelong intestinal problems such as ischemia and/or portal hypertension. We present the case of a 33-year-old man with a history of autoimmune hemolytic anemia and splenectomy who developed mesenteric ischemia. The patient experienced abdominal pain and diarrhea, and imaging studies revealed mesenteric vein thrombosis. Surgical intervention confirmed the diagnosis. This case significantly contributes to the existing literature by providing insights into the occurrence of mesenteric ischemia in younger individuals with predisposing factors, as well as its clinical presentation, diagnostic challenges, and severity. Moreover, it has implications for the future diagnosis and management of long-term mesenteric ischemia in patients who have undergone splenectomy for hemolytic anemia.
What We Know about Euterpe Genus and Neuroprotection: A Scoping Review
Authors: Da Silva Ilano Oliveira , Crespo-Lopez Maria Elena , Augusto-Oliveira Marcus , Arrifano Gabriela de Paula , Ramos-Nunes Natália Raphaela , Gomes Elielton Barreto , da Silva Felipe Rodolfo Pereira , de Sousa Aline Andrade , Leal Alessandro Luiz Araújo Bentes , Damasceno Helane Conceição , de Oliveira Ana Carolina Alves , Souza-Monteiro José Rogério
Published: July 2023

The Euterpe genus (mainly Euterpe oleracea Martius, Euterpe precatoria Martius, and Euterpe edulis Martius) has recently gained commercial and scientific notoriety due to the high nutritional value of its fruits, which are rich in polyphenols (phenolic acids and anthocyanins) and have potent antioxidant activity. These characteristics have contributed to the increased number of neuropharmacological evaluations of the three species over the last 10 years, especially açaí of the species Euterpe oleracea Martius. The fruits of the three species exert neuroprotective effects through the modulation of inflammatory and oxidative pathways and other mechanisms, including the inhibition of the mTOR pathway and protection of the blood–brain barrier, all of them intimately involved in several neuropathologies. Thus, a better understanding of the neuropharmacological properties of these three species may open new paths for the development of therapeutic tools aimed at preventing and treating a variety of neurological conditions.
Association between Serum Selenium Levels and Lipids among People with and without Diabetes
Authors: Nie Qi , Wang Changsi , Zhou Li
Published: July 2023

The current study aimed to examine the association between serum selenium levels and lipids and explore whether the association was modified by diabetic status. A total of 4132 adults from the National Health and Nutrition Examination Survey (2011–2016) were included in this study. Multiple linear regression models were used to estimate the association between serum selenium and lipids. Higher serum selenium levels were significantly associated with increased total cholesterol (TC) (p < 0.001), triglyceride (TG) (p = 0.003), and low-density lipoprotein cholesterol (LDL-C) (p = 0.003) in the overall population. Diabetic status interacted with serum selenium for TC and LDL-C (p for interaction = 0.007 and <0.001). Comparing the highest with the lowest tertiles of serum selenium, the multivariate-adjusted β coefficients (95% CIs) were 17.88 (10.89, 24.87) for TC, 13.43 (7.68, 19.18) for LDL-C among subjects without diabetes, but nonsignificant among those with diabetes. In US adults, the serum selenium was positively associated with lipids and the association was modified by diabetic status. Higher serum selenium levels were significantly associated with increased TC and LDL-C among participants without diabetes, but not among participants with diabetes.
To Guide or to Self-Guide?: Predictors of Preferring a Guided Introduction to Digital Resources That Promote Postpartum Mental Health
Authors: Albanese Ariana M. , Smith Betsy E. , Geller Pamela A. , Bloch Joan R. , Sikes Chris , Kondracki Anthony J. , Barkin Jennifer L.
Published: July 2023

The first postpartum year presents threats to the mental health of birthing parents and obstacles to accessing care. Digital mental health interventions (DMHIs) hold potential to increase postpartum mental healthcare access. However, DMHIs tend to promote limited engagement particularly when they are self-guided (when they do not involve contact with a provider). Yet, given that provider support is a limited resource, a balance must be struck between accessibility and intervention intensity (i.e., involving more human contact). Towards achieving this balance, this analysis seeks to identify characteristics that are associated with a reported preference for a human-guided introduction to digital resources aimed at promoting postpartum mental health. In a sample of largely White, non-Latinx, employed, married, and graduate school-educated individuals, multivariate logistic regression revealed that age (p = 0.0095), level of postpartum functioning (p = 0.0057), depression symptoms (p = 0.0099), and anxiety symptoms (p = 0.03) were associated with guide preference. Specifically, more anxious or lower-postpartum-functioning individuals were more likely to report preferring a guide while older or more depressed individuals were less likely to report preferring a guide. These findings can inform clinical recommendations surrounding who is most likely to engage with, and thus benefit from, exclusively self-guided DMHIs during the postpartum period.
Applications of the Symmetric Quantum-Difference Operator for New Subclasses of Meromorphic Functions
Authors: Al-shbeil Isra , Khan Shahid , AlAqad Hala , Alnabulsi Salam , Khan Mohammad Faisal
Published: July 2023

Our goal in this article is to use ideas from symmetric q-calculus operator theory in the study of meromorphic functions on the punctured unit disc and to propose a novel symmetric q-difference operator for these functions. A few additional classes of meromorphic functions are then defined in light of this new symmetric q-difference operator. We prove many useful conclusions regarding these newly constructed classes of meromorphic functions, such as convolution, subordination features, integral representations, and necessary conditions. The technique presented in this article may be used to produce a wide variety of new types of generalized symmetric q-difference operators, which can subsequently be used to investigate a wide variety of new classes of analytic and meromorphic functions related to symmetric quantum calculus.
Effects of Internal Boundary Layers and Sensitivity on Frequency Response of Shells of Revolution
Authors: Hakula Harri
Published: July 2023

New applications introduced capsule designs with features that have not been fully analysed in the literature. In this study, thin shells of revolution are used to model drug delivery capsules both with closed and open designs including perforations. The effects of internal boundary layers and sensitivity on frequency response are discussed in the special case with symmetric concentrated load. The simulations are carried out using high-order finite element method and the frequency response is computed with a very accurate low-rank approximation. Due to the propagation of the singularities induced by the concentrated loads, the most energetic responses do not necessarily include a pinch-through at the point of action. In sensitive configurations, the presence of regions with elliptic curvature leads to strong oscillations at lower frequencies. The amplitudes of these oscillations decay as the frequencies increase. For efficient and reliable analysis of such structures, it is necessary to understand the intricate interplay of loading types and geometry, including the effects of the chosen shell models.
Diagnóstico da cadeia produtiva de caprinos e ovinos no Brasil e na região Nordeste
Authors: Santos Willyane de Souza , Albuquerque Héldon José Oliveira , Albuquerque Hidelberg Oliveira , Cabral Ana Maria Duarte , Ferreira Fernando Felipe da Silva , Santos Edja Sabrina Sá , Nascimento Maria Izabel de Souza Sá , Santos Girlene Cordeiro de Lima
Published: July 2023

Esta revisão teve como base o diagnóstico da cadeia produtiva de caprinos e ovinos no Brasil e na região Nordeste. O estudo permite o conhecimento sobre o perfil da produção atual brasileira dos principais produtos oriundos da exploração da ovinocultura no país, auxiliando no entendimento sobre os principais manejos utilizados, os principais produtos e subprodutos comercializados, bem como os cuidados durante o processo de abate desses animais; fatores que comprometem o produto final, logo, afetam diretamente o produtor. Outra vertente a ser destacada é o uso de tecnologias como ferramenta de trabalho no campo por meio de aplicativos para dispositivos móveis que venham a contribuir com o monitoramento da produção diária/mensal/anual da propriedade. O trabalho foi realizado a partir de uma abordagem descritiva e embasada por uma revisão de literatura, por meio do levantamento de dados eletrônicos, livros e publicações científicas. É destacada a importância da produção de caprinos e ovinos em todo país, e principalmente, para a região Nordeste, onde se concentra a maior fração da produção. Porém, para que o mercado seja competitivo, a cadeia de produção de carne e derivados da caprinovinocultura deverá sofrer reajustes no abate, que na maioria das vezes é feito de forma clandestina e sem nenhum tipo de fiscalização. Dentre os principais produtos comercializados se destacam-se a carne e o leite, e na sequência seus subprodutos como a pele e vísceras. Por final, o uso de tecnologias vem ganhando força no campo, facilitando a escrituração zootécnica das propriedades, porém, para que seja difundida, toda a cadeia produtiva precisa de maior fiscalização por parte dos órgãos competentes, garantindo um produto de qualidade e de procedência reconhecida.
Policial militar enquanto testemunha em processo criminal: o uso da câmera corporal com o objetivo de preservação da prova penal dependente da memória
Authors: De Oliveira Marjori Beatriz Soares
Published: July 2023

O objetivo principal do presente estudo é analisar o benefício do uso de câmera corporal pela Polícia Militar do Estado do Paraná para o processo penal, sobretudo, como forma de preservar a prova dependente da memória, e auxiliar na persecução penal. Nessa perspectiva, a prova penal constitui elemento fundamental para elucidação de um fato criminoso, é através dela que se chega à verdade processual dos fatos pretéritos, assim é componente essencial para uma decisão judicial adequada. Dentre os meios de provas admitidos no ordenamento jurídico a prova testemunhal ganha destaque, em que pese sua fragilidade, e todas as incertezas que a envolvem, ainda culmina em ser o meio de probatório mais utilizado no âmbito jurídico. Assim, considerando ampla participação dos policiais militares como testemunha em processos criminais, entender que a memória humana é falha e está sujeita a interferências e ao perecimento com passar do tempo, e utilizar-se de mecanismos que possam preservar a prova penal advinda da memória destes agentes, é contribuir para um deslinde processual justo.
Pré-eclâmpsia: fisiopatologia, diagnóstico e manejo terapêutico
Authors: Melillo Vitória Teixeira , Ferreira Ana Carolina Oliveira , Chagas Afonso Pena de Azevedo , Munayer Lara Abras Gomes , Serejo Mônica Bertho Boaventura , Figueiredo Natália Generoso , Eiri Karina Akemi , Aquino Ana Paula Martins , Nascimento Francis Henrique , Ferreira Julia Rayane
Published: July 2023

A Pré-eclâmpsia (PE) é uma doença da gestação que é caracterizada, de forma simplificada, pela elevação dos valores pressóricos, juntamente com a presença de proteinúria após a 20ª semana. Diversos fatores de risco podem estar relacionados com o surgimento da doença, dentre eles, pode-se citar o histórico familiar de PE, predisposição genética, tabagismo, idade materna, nuliparidade, fertilização in vitro, hipertensão arterial crônica, diabetes, doença renal crônica, obesidade e doenças autoimunes. A fisiopatologia da PE está relacionada com dois mecanismos diferentes, sendo eles a placentação anormal e o desenvolvimento da síndrome materna. No que tange ao diagnóstico da doença, os principais critérios são o aumento da pressão arterial (PA) acima de 20 semanas de gestação, associado à proteinúria. Todavia, mesmo na ausência de proteinúria, é possível que o diagnóstico seja feito caso haja um aumento da PA associado ao aumento da creatinina, transaminases hepáticas, trombocitopenia, edema pulmonar ou sintomas visuais/cerebrais. A abordagem terapêutica gira em torno do acompanhamento, suporte para a gestante e controle da pressão arterial, que possui diferentes recomendações para os diferentes graus de hipertensão. Ademais, vale mencionar que a gestão da gravidez, a data ideal do parto e os cuidados para com a gestante devem ser individualizados, a depender da presença ou não de sinais de deterioração e também da idade gestacional em que o feto se encontra.
Estrategias de marketing digital para posicionar la marca ciudad Bahía de Caráquez, Cantón
Authors: López Esteban Arroyo , Quintero Frank Ángel Lemoine
Published: July 2023

La importancia del lenguaje de marketing digital se ha hecho muy evidente en los planes de publicidad y por ende contenido digital debido a que el mercado esta cada vez mas competitivo, por esta razón y con las herramientas bien utilizadas se puede llenar las expectativas del posible consumidor turístico potencial. El presente trabajo pretende desde el contexto buscar estrategias de marketing digital para posicionar la marca ciudad de Bahía de Caráquez del cantón Sucre como un destino turístico multicultural. Estudios desarrollados por proyecto de investigación I+D+i en la extensión Sucre han demostrado no lograr las expectativas para fortalecer las actividades turísticas. El objetivo es desarrollar estrategias de marketing digital para posicionar la marca ciudad Bahía de Caráquez. La metodología de la presente investigación es de enfoque mixto en base a las plataformas digitales para diagnosticar nivel de calidad de cada servicio tecnológico que utilizan las personas al momento de visitar la ciudad, la investigación es de carácter cualitativo y cuantitativo, a través del método aleatorio por conveniencia e ilustrativo descriptivo, verificando los niveles de aceptación a través del muestreo aleatorio simple no probabilístico se llegó a la indagación de la plataforma YouTube que es donde mas hay contenido sobre la ciudad. Bahía de Caráquez es un destino turístico que en la actualidad no cuenta con un posicionamiento solido como marca ciudad, por eso en base a las investigaciones realizadas se identificaron varias falencias al momento de desarrollar la respectiva publicidad.
Criação de material didático no ensino da anatomia veterinária: angiotécnica
Authors: de Oliveira Valberto Barbosa , Da Silva Aline Beatriz Batista , de Barros Gabriel Bezerra , Martins Letícia Simplício González , De Sousa Luana , Dos Santos Luís Henrique das Neves Costa , Batista José Alberto Duarte Gomes , Silva Gedean Galdino da Cruz
Published: July 2023

As técnicas anatômicas têm sido utilizadas para a preparação de peças para o ensino prático da anatomia, principalmente a macroscópica. Essas técnicas desenvolvidas facilitam o trabalho dos professores durante o ensino e melhoram a compreensão do conteúdo didático. Desta maneira o presente trabalho objetivou desenvolver uma peça anatômica, detalhando o processo de realização da angiotécnica, e apresentando o material como opção de ensino diferenciado das estruturas anatômicas vasculares do rim suíno. A angiotécnica foi realizada em duas etapas: primeiramente a repleção, que consiste no preenchimento de ductos dos vasos sanguíneos dos rins, por meio de injeção de soluções de resina em seu interior. A segunda etapa consistiu na eliminação do tecido orgânico da amostra com ácido HCl, para visibilizar os ductos com resina, essa etapa é chamada de corrosão. O modelo preparado apresentou claramente as artérias, veias e suas ramificações, permitindo a observação de estruturas menores como capilares, mostrando que o órgão renal é bem vascularizado. A técnica demostrou ser uma opção didática válida no ensino do morfológico devido à perfeita observação das estruturas vasculares, permitindo o manuseio prático por parte do corpo docente e discente no ensino da anatomia veterinária.
Methodological activity of the teacher of a higher education institution
Authors: Nikolishina Е.V. , Boychenko O.M.
Published: July 2023

Considered the main aspects and identified the main tasks of methodical work of a teacher of higher education, which consist of improving methodological skills, improving the organization and provision of educational process for students, introduction of new teaching methods in the educational process both practical and theoretical parts of the lesson. For a modem teacher to effectively teach the discipline, it is important to understand the structure of the teacher, its main components, constantly improve pedagogical activities, practical skills and constantly develop the psychological qualities necessary for professional implementation. The teacher of a higher education institution carries out his activity in several directions at once: scientific, educational and methodical. In order for the work to be interesting and useful, it is necessary to pay more attention to the analysis of teachers' work, both individually and collectively, which is conducted at the beginning and end of the school year, complicated the educational process, as well as to develop a plan of methodological activities for the next year.

Keywords: teacher, methodical work, activation of activity.
Analytical Modeling of Buckling of Carbon Nanotubes Reinforced Sandwich-Structured Composite Shells Resting on Elastic Foundations
Authors: TIMESLI Abdelaziz
Published: July 2023

Sandwich-Structured Composites (SSCs) are widely used in lightweight construction, especially in the aerospace sector, due to their high specific stiffness and strength. Therefore, it is important to develop their quality by using new techniques. Today, nanotechnologies offer new perspectives for the reinforcement of construction materials. This paper assumes that the reinforcement of the sandwich shell is performed by CNT reinforced face sheets with a uniform or Functionally Graded (FG) distribution of CNTs. The effective properties of the Carbon Nanotubes Reinforced Sandwich-Structured Composite (CNT-RSSC) shells are calculated using the rule of mixture. This study presents novel exact analytical formulas to predict the critical buckling load of the CNT-RSSC shells resting on elastic foundations based on Donnell cylindrical shell theory. These analytical formulas provide the most meaningful answer because we get an equation showing us exactly what happens with each variable. The effects of various parameters on the buckling stability of the RSSC shells are examined.
COMPARISON OF DIAGNOSTIC EVALUATION OF FNAC AND SONOGRAPHIC FEATURES WITH HISTOPATHOLOGY IN BREAST LUMP
Authors: Maheswari R. , Thomas Rajkumar Joe , G. P. Nair Indran , Sajan Stanly
Published: July 2023

Background: Breast diseases and tumours are frequently seen in outpatient department. Women are becoming more aware, and with that awareness comes more anxiety and stress as they mistake every breast symptom for cancer. Hence, in hopes of assuring patients and provide the best treatment possible, a method of conclusive diagnosis for those who appear with breast lumps in the outpatient clinic is required. An important part of diagnosing these lesions is the use of Sonomammography or breast ultrasound (USG), ne needle aspiration cytology (FNAC), and histopathological evaluation. Aim: To nd out the outcome of comparison of Diagnostic Evaluation of FNAC, Sonomammography with Histopathological features in case of breast lump in a Tertiary care centre. Materials and Method: The present study is a retrospective study conducted for a period of 18 months in a tertiary care centre in south India. Atotal of 71 cases were included in the study. Clinical data, sonographicndings, cytology and histopathological examination ndings were collected. Result were analysed using SPSS 20.0 version and the association was tested using Chi square test. Results: Among 71 cases FNAC report ndings suggest 33.8% were malignant, 56.3%benign and 9.9% inconclusive while USG report ndings suggest 31% were malignant, 56.3% benign and 12.7% inconclusive. On comparison with histopathological diagnosis, nipple discharge, pain over lump, constancy of the swelling, axillary node involvement, USG and FNAC showed statistical signicance All the 71 patients included in study were subjected to some form of surgery. FNAC showed sensitivity of 92.31%, specicity of 88.89%, positive predictive value (PPV) of 82.76%, negative predictive value (NPV) of 95.24% and 90.14% accuracy. USG showed sensitivity of 84.62%, specicity of 88.89%, PPV of 81.48%, NPV of 90.91% and 87.32% accuracy. Conclusion: While histological diagnosis following the biopsy is still the gold standard, FNAC offers greater accuracy than other investigational modalities prior to surgery. For the early identication and treatment of breast lumps, FNAC, sonography, histopathology, and combinations of all three modalities are benecial.
Automation of the drilling machine by CoDeSys
Authors:   Andreev I.A.
Published: July 2023

The issues of automation of technological processes in metalworking are considered. A program for the implementation of a drilling machine automatic control based on a programmable logic controller (PLC) is given.

Keywords
automation in mechanical engineering, technological process, programmable logic controller, visualization, emulation
Особливості застосування чисельних методів для аналізу напруженого стану пористих будівельних матеріалів
Authors: Заякін Д.К. , Мікуліч О.А.
Published: July 2023

Робота присвячена аналізу меж придатності основних числових методів прикладної математики до аналізу механічної поведінки структурно-неоднорідних будівельних матеріалів, а також визначенню основних переваг та обмежень при їх застосуванні. У роботі здійснено порівняльний аналіз наступних методів: метод скінченних елементів, метод граничних елементів, метод сіток, метод кінцевих різниць. У роботі також розглянуто можливі комбінації вказаних методів для зменшення похибки числових розрахунків.
Теплова надійність стін житлових будівель У регіонах україни
Authors: Карюк А.М.
Published: July 2023

За раніше розробленою методикою для 26 регіонів України отримані імовірні тривалості стану теплової відмови стін житлових будівель за критерієм перевищення допустимого температурного перепаду між внутрішнім повітрям і внутрішньою поверхнею огородження. Встановлено, що в межах території України тривалості теплових відмов змінюються в межах 14…28 хвилин/рік. Аналіз їх територіальної мінливості вказує на можливість розділення першої температурної зони України на дві зони з дещо різними значеннями мінімально необхідного опору теплопередачі стін. АР Крим та Південний берег Криму також можна виділити в окремі зони, встановивши для них понижені значення мінімально необхідного опору теплопередачі стін.
The Blue Flag Award in South Africa: Raising Consciences and Influencing Beach Goers’ Decisions
Authors: Mukaronda Lesleen Chenesai , Sucheran Reshma
Published: July 2023

In recent years, the tourism sector has experienced significant expansion, with the beach ecosystem emerging as the most popular destination for recreational and leisure pursuits. The proliferation of marine tourism activities has resulted in undeniable ecological consequences, including
but not limited to the generation of solid waste, noise and air pollution, unattractive landscapes, and degradation of the coastal biome. The Blue Flag certification has been widely embraced by several coastal municipalities as a means of addressing the adverse environmental consequences that
arise from tourism and recreational activities. The objective of this research is to evaluate the perceptions and level of awareness of beach visitors regarding the Blue Flag award, as well as determine if their selection of a beach destination is influenced by the Blue Flag standards. The
study employed a quantitative methodology and gathered data, using convenience sampling, from beach visitors at nine Blue Flag beaches located in KwaZulu-Natal. The data were collected through a structured, self-administered questionnaire. The findings suggest that there is a dearth of awareness
among beach visitors regarding the Blue Flag certification and that certain criteria associated with the award have an impact on their selection of beaches. The study is expected to yield significant advantages in enhancing and strengthening the Blue Flag certification program within the country
at large. Additionally, it will promote the necessity of public environmental education and awareness regarding the award.
The microRNA-144/451 cluster in plasma-derived microvesicles and erythrocytes in patients with history of pulmonary embolism
Authors: Sirotkina O. V. , Ulitina A. S. , Zhilenkova Y. I. , Zolotova E. A. , Simakova M. A. , Moiseeva O. M. , Vavilova T. V.
Published: July 2023

Chronic thromboembolic disease (CTED) and chronic thromboembolic pulmonary hypertension (CTEPH) are the complications that comprise a serious problem for patients with history of pulmonary embolism (PE). Erythrocytes, extracellular microvesicles (EMVs) and miRNAs play a substantial role in the procoagulant states. The aim. To analyze the levels of miR-144-3р, miR-451a, and miR-451b in blood plasma-derived EMVs and erythrocytes in patients with history of PE and in the control group. Materials and Methods. 18 patients with history of PE (13 CTEPH, 5 CTED) and 8 controls were enrolled into the study. All the participants had undergone clinical and biochemical blood tests as well as the coagulogram. We used flow cytometry to assess plasma-derived EMVs (CD9, CD41, CD45, CD235a, CD105). We measured the expression of miR-144-3р, miR-451a, miR-451b by real-time PCR with endogenous control (miR-152-3p) and five exogenous quality controls. Results. The levels of miR-144-3р and miR-451a in patients were lower than in controls, both in EMVs (р = 0.030; р = 0.065) and in erythrocytes (р = 0.023;р = 0.086). In female patients, the levels of miR-144-3р and miR-451a in CTEPH were lower than in CTED (р = 0.087; р = 0.031). Mir-451b in EMVs has not been detected, while in erythrocytes its levels have not differed between the groups. In patients, the levels of miR-144-3р and miR-451a directly correlated with each other both in EMVs (р = 0.004) and in erythrocytes (р = 0.042). In all the participants, the levels of miR-144-3р and miR-451a in EMVs directly correlated with those in erythrocytes (р = 0.002; р = 0.078). The number of erythrocyte-derived EMVs correlated with miR-451a levels both in EMVs (R = 0.472; p = 0.065) and in erythrocytes (R = –0.829; p = 0.011). The level of miR-451a in EMVs correlated with blood plasma levels of factor VIII and fibrinogen (R = 0.584; p = 0.022 and R= –0.489; p = 0.047), and with the International Normalized Ratio (R = 0.894; p = 0.041). Conclusion. The microRNA-144/451 cluster may influence both the hemostasis system and the risk of post-thromboembolic complications development. In the present study, miR-144-3р and miR-451a showed themselves as protective factors in relation to both the development of PE and severity of post-thromboembolic complications.
Comparative study of the CYP2C19, CYP2C9, CYP4F2 gene polymorphisms impact on the clinical and laboratory characteristics of acute coronary syndrome patients
Authors: Kantemirova B. I. , Abdullaev M. A. , Chernysheva E. N. , Kitiashvili I. Z. , Zharkov Z. V. , Romanova A. N. , Konovalova E. R.
Published: July 2023

Coronary heart disease (CHD) is one of the most common causes of death worldwide. The pharmacokinetic properties of drugs used to treat coronary heart disease depend on genetic factors, including the genotype of CYP2C19, CYP2C9 and CYP4F2. However, existing studies of the genetic basis of the response to treatment in patients with acute coronary syndrome (ACS) have contradictory results, requiring a more detailed study. Goal. In this study, we studied the distribution of the genotypes of CYP2C19*2, CYP2C9*2 and CYP4F2*3 among 59 patients diagnosed with ACS who received dual antiplatelet therapy. Methods. The polymerase chain reaction (PCR) method was used to determine the genotypes of CYP2C19, CYP2C9 and CYP4F2. A correlation analysis of the results of genotype carriage and clinical and laboratory parameters of patients was carried out. Results. The distribution of CYP2C9*2 genotypes was as follows: wild genotype (CC) was found with a frequency of 78 % (45 patients), heterozygotes (CT) — 22 % (12 patients), homozygotes (TT) were not detected. The CYP4F2*3 genotype was distributed as follows: 56.14 % (32 patients) had a wild genotype (CC), 31.5 % (18 patients) were heterozygotes with reduced enzyme activity (CT), 12.36 % (7 patients) were homozygotes for the T (TT) allele. The distribution of alleles and genotypes of CYP2C9 did not correspond to the Hardy-Weinberg equation (χ2 = 21.55; p = 0.044), while the distribution of alleles and genotypes of CYP4F2 corresponded to it (χ2 = 3.61; p = 0.0574). Conclusion. The study showed a high prevalence of the genotypes CYP2C9*2 (CT) and CYP4F2*3 (CT and TT) among patients with acute coronary syndrome. The carriage of CYP2C19*2 was significantly associated with adverse cardiovascular events in patients. These results suggest that genetic testing can provide valuable information for risk stratification and personalized treatment of patients with acute coronary syndrome
Supervisi Pendidikan Persfektif Islam
Authors: Nuraini
Published: July 2023

The aim of educational supervision is to provide technical assistance and guidance to teachers and other school staff so that these personnel are able to improve the quality of their performance, especially in carrying out tasks, namely carrying out the learning process. Furthermore, if the quality of the performance of teachers and staff has increased. educational supervision provides assistance in the form of continuous guidance both individually and in groups in improving learning so as to improve the quality of the school as a whole. Controlling or supervision in Arabic has the same meaning as the word ar-Riqobah. In the Qur'an, this word is mentioned in several verses which generally indicate the existence of a supervisory function. Ar-riqobah is knowing the actual events with the rules and regulations, as well as pointing precisely to the bases that have been set in the original planning. In this context, sharia implementation is realized through three pillars of supervision, namely: 1) individual piety, that all company personnel are ensured and nurtured to become pious human beings; 2) supervision of members, in an organizational atmosphere that reflects a team, the organization's sustainability process will always receive supervision from its personnel in accordance with the direction that has been set; 3) Implementation/supremacy of rules, organizations are upheld by clear and transparent rules of the game and are not against sharia.
A case of acute infective endocarditis and septic shock
Authors: Dobreva-Yatseva B. , Nikolov F. , Raycheva R. , Stanev K. , Ivanova N. , Nikolov P. , Tokmakova M.
Published: July 2023

Infective endocarditis (IE) marks an increasing morbidity and unchanged mortality despite advances in its diagnosis and treatment. In about 20% of IE cases are acute, with signs of sepsis and septic shock. Septic shock dramatically worsens prognosis and is an independent predictor of in – hospital death. Timely diagnosis and urgent surgical intervention can improve survival in these patients. We present a case of a 47-year-old man, with no history of past or concomitant diseases, who was admitted as an emergency to the Cardiology Intensive Care Unit, during the Covid-19 pandemic, with pronounced febrile-intoxication syndrome, shortness of breath, precordial discomfort and pain, cough, haemoptysis. From laboratory studies with a pronounced infl ammatory constellation, troponin I and D-dimers are also increased. This case shows the diffi culties in the diagnosis of acute IE, the specifi cs in the clinical course of the disease, as well as the importance of urgent surgical intervention to improve survival.
A novel decision model with Einstein aggregation approach for garbage disposal plant site selection under $ q $-rung orthopair hesitant fuzzy rough information
Authors: Attaullah  , Khan Asghar , Rehman Noor , Al-Duais Fuad S. , Al-Bossly Afrah , Al-Essa Laila A. , Tag-eldin Elsayed M
Published: July 2023

Environmental science and pollution research has benefits around the globe. Human activity produces more garbage throughout the day as the world's population and lifestyles rise. Choosing a garbage disposal site (GDS) is crucial to effective disposal. In illuminated of the advancements in society, decision-makers concede a significant challenge for assessing an appropriate location for a garbage disposal site. This research used a multi-attribute decision-making (MADM) approach based on $ q $-rung orthopair hesitant fuzzy rough ($ q $-ROHFR) Einstein aggregation information for evaluating GDS selection schemes and providing decision-making (DM) support to select a suitable waste disposal site. In this study, first, q-ROHFR Einstein average aggregation operators are integrated. Some intriguing characteristics of the suggested operators, such as monotonicity, idempotence and boundedness were also explored. Then, a MADM technique was established using the novel concept of $ q $-ROHFR aggregation operators under Einstein t-norm and t-conorm. In order to help the decision makers (DMs) make a final choice, this technique aims to rank and choose an alternative from a collection of feasible alternatives, as well as to propose a solution based on the ranking of alternatives for a problem with conflicting criteria. The model's adaptability and validity are then demonstrated by an analysis and solution of a numerical issue involving garbage disposal plant site selection. We performed a the sensitivity analysis of the proposed aggregation operators to determine the outcomes of the decision-making procedure. To highlight the potential of our new method, we performed a comparison study using the novel extended TOPSIS and VIKOR schemes based on $ q $-ROHFR information. Furthermore, we compared the results with those existing in the literature. The findings demonstrate that this methodology has a larger range of information representation, more flexibility in the assessment environment, and improved consistency in evaluation results.
Peace, jus gentium and ethics in the work of Pietro Tamburini (1737-1827)
Authors: Grasso Grazia
Published: July 2023

Si le XVIIIe siècle se caractérise par l’importance de la notion de tolérance, le droit de paix s’y avère également un concept central. En outre, émerge, à l’époque des Lumières, l’idée de la nécessité du respect de l’humanité en temps de guerre, ce qui constituera, plus tard, le fondement du droit humanitaire. Dans ce contexte se place aussi la production littéraire de Pietro Tamburini (1737-1827), un abbé janséniste de Brescia et professeur de droit à Pavie. Il fut fortement influencé par les théories du droit naturel et spécialement par les auteurs de l'École romande. Pourtant, sa production sur le thème de la paix a été, à tort, négligée jusqu’à aujourd'hui.
Introduction to Neuromorphic Computing Systems
Authors: Ahmed L. Jubair , Dhanasekar S. , Sagayam K. Martin , Vijh Surbhi , Tyagi Vipin , Singh Mayank , Norta Alex
Published: July 2023

The process of using electronic circuits to replicate the neurobiological architectures seen in the nervous system is known as neuromorphic engineering, also referred to as neuromorphic computing. These technologies are essential for the future of computing, although most of the work in neuromorphic computing has been focused on hardware development. The execution speed, energy efficiency, accessibility and robustness against local failures are vital advantages of neuromorphic computing over conventional methods. Spiking neural networks are generated using neuromorphic computing. This chapter covers the basic ideas of neuromorphic engineering, neuromorphic computing, and its motivating factors and challenges. Deep learning models are frequently referred to as deep neural networks because deep learning techniques use neural network topologies. Deep learning techniques and their different architectures were also covered in this section. Furthermore, Emerging memory Devices for neuromorphic systems and neuromorphic circuits were illustrated.
The Implications of COVID-19 for Fostering Diversity and Inclusion Through Curriculum Transformation
Authors: Van Heerden Dalize , Goosen Leila
Published: July 2023

The purpose of this chapter is to provide research on issues from a curriculum transformation perspective regarding teaching information and communication technology (ICT) students in open distance e-learning (ODeL) contexts, and the implications of COVID-19 and the future of such teaching and learning in the age of the fourth industrial revolution (4IR). The objectives of this contribution are aimed at addressing the research questions regarding the challenges faced by university pedagogy today, the extent to which ICTs can enhance teaching and learning, and what transformative assessment entails.
Big Data Supply Chain Management and Its Legal Context
Authors: Taghipour Atour , Lu XiaoWen
Published: July 2023

The new digital tools can significantly improve the performance of supply chains. That means, the digitalization has the potential to provide companies with a range of practices to significantly reduce costs, increase product availability, improve access to information, and enhance responsiveness, collaboration, supply chain visibility, and resilience. One of the potentials of the digitalization is to explore big data. In fact, the quantitative explosion of data gave birth to big data in order to find new ways of analyzing and exploring the data. It offers the possibility to treat and analyze a huge amount of data in order to make conclusions and take decisions. Benefits such as cost reducing, better management, or even precise forecasting are possible with the big data. But a lot of companies have faced big problems such as data leaking and privacy violation. This chapter will study big data supply chain management and its legal context based on a literature review and gives future directions for governments, companies, and researchers.