bluuebunny/crossref_metadata_2025 huggingface dataset:
Restitution as a Requirement for the Implementation of Restorative Justice Against General Crimes Related to Property
Authors: Muwardi Ardito , Surono Agus , Nugroho Hibnu
Published: February 2023

Restitution is a monetary remedy paid by a perpetrator or a third party to a victim or their family. It can be implemented by returning property, payment for losses or suffering, or reimbursement of costs. However, restitution is not applicable to all types of crimes; thus, not all victims have access to it.The issue of legal protection for victims is still an ongoing discourse, and many parties believe that its implementation is still far from perfect and in need of legal reform due to the inability of the perpetrators to pay restitution to the victims. This study uses qualitative methods by examining secondary data such as documents, laws and regulations, scientific findings, and books. This study finds that the application of restorative justice in criminal cases, especially property crimes provides certain flexibility for the community to search for a settlement. The perpetrator paying for restitution is an absolute requirement for restorative justice in settlement of property-related crime as an alternative to the conventional court proceeding. Moreover, the perpetrators, victims, and the community can all be involved in a discussion process to reach a consensus regarding a solution to a conflict avoiding harming any parties, for instance, a settlement without punishment.
Keywords: restitution, restorative justice, criminal act, property
Social Resilience Strategies Through Community-Based Tourism In The Era Of New Habits Adaptation
Authors: Luthfitah Rifdah , . Suryoto , . Ranjani
Published: February 2023

Indonesia is one of many nations whose economies have been crippled by the COVID- 19 outbreak. The reduction in per capita income, which has an effect on the community’s social resilience, is directly impacted by COVID-19. Through community-based tourism, this study intends to identify the social resilience strategy in Banyumas District, Banyumas Regency, in the age of habit adaption. In-depth interviews, documentation, and observation are the three methods of data collection using qualitative approaches. The study’s findings suggest that the COVID-19 pandemic is to blame for a region’s declining socioeconomic resilience, particularly for the welfare of those who depend on the tourism industry. The Banyumas District government’s ”Peken Banyumasan” community-based tourism initiative is employed as a tactic to sustain socioeconomic resilience in Banyumas District, Banyumas Regency. Community-based tourism has not yet completely realized its potential. This is a result of Ketenger Village’s lack of community involvement and the Regional Government’s dominance as the event organizer and planner.
Keywords: covid-19, community-based tourism, social resilience
“MAKE THE MOST OF EVERYTHING”: THE WORLD AS A RESOURCE IN 1920s CHILDREN’S NON-FICTION
Authors: Kazakova Elena O.
Published: February 2023

The article discusses the process of building a “resource approach” in relation to nature in early Soviet children’s non-fiction. On examples from books on energy, technology, minerals, flora and fauna, it is shown how the sentimentalization of nature is abandoned and redirected towards consumer discourse. Methodologically the article is in the zone of intersection of literary approaches, adhering to the tradition of rhetoric studies and attempts to contextualize it, using the arsenal of digital humanities and automated construction of concordance according to the lemmas “benefit”, “useful”, “use” with the corpus tool (DetKorpus). The analysis of the identified contexts of word usage demonstrates how, with the help of the concept of “benefit”, authors create a new way of nature management in the readers’ minds, in which “taking advantage” becomes a key condition in interaction with the outside world. With regard to the extraction of raw materials, energy resources, the development of territories, and wildlife, authors use the rhetoric of “metaphorical violence” – the suppression and coercion of free natural forces that should be put at the service of man. Such ideological components of this phenomenon as the campaign to promote the first five-year plan and M. Gorky’s texts, conceptualizing the project of an anthropocentric world, in which a person acts as a source of power, reorganizing the “first nature” into culture – “second nature”, are considered. The existence of a special trend within the framework of non-fiction, formed by a specific author’s rhetoric, with a double pragmatics of texts, consisting not only the translation of ideas, but also involvement of children in economic and production processes, is summarized.
THE OSTENSIVE AND THE EMP(H)ATIC: TYNYANOV IN THE CURVE OF DERRIDA
Authors: Markov Alexander V.
Published: February 2023

The critical method developed by Jacques Derrida requires a new attitude to ostensiveness: it is understood not as a quality of argument, but as a way of arranging heterogeneous utterances by placing human beings before their own history. This allows us to overcome the inconsistencies in our conception of how humans construct their own and others’ histories, and how the means of speech always lag this constituting. The article argues that Russian formalism, which demonstrates numerous parallels with Husserl’s phenomenology, preceded Derrida’s project of building a non-contradictory theory of ostensibility. Tynyanov, with his interest in biographies, theater and the visual properties of the written text, through a series of complex arguments and an overcoming the unspoken in the usual concepts of expressiveness was able to create an idea of man, who is both a producer and a consumer of art, a character of emphatic statements, which reveals the extensive potential of culture. The contradictions and shortcomings in metaphors and schemes, through which Tynyanov describes the art of past eras, are surmounted in his own literary work, which transfers the antinomy of subject and story from the realm of supposition into the realm of ostensive acceptance. Taking into account these particular ideas helps us to clarify the concept of time as part of Tynyanov’s study of visual techniques in the poetic text and the fluctuating characteristics of linguistic meaning.
“ARTIFICIAL PRINCESS” BY RONALD FIRBENK AS A STYLIZATION “UNDER THE HILL” BY AUBREY BEARDSLEY
Authors: Novokreshchennykh Irina A.
Published: February 2023

The article is devoted to the analysis of stylization of Aubrey Beardsley’s “Under the Hill” presented in the Ronald Firbenk’s novel “The Artificial Princess”. Research methodology is a combination of literary historical, intertextual, intermedial approaches with biographical one. Beardsley’s style is recognized and reproduced by Firbenk through the scent motif, the hair motif, the costume motif, and the pastiche principle. The details of the biography, related to dandyism, creative manner, specifics of fragmentation and incompleteness, as well as genre similarities of the works allow Firbenk both to express Beardsley’s style, and his own attitude towards it. Beardsley’s style is an embodiment of the aestheticism of the period (the end of 19th- the beginning of 20th centuries). Firbank attempted to reanimate and revive Beardsley’s style to be attuned to modernism. The scent motif is a vivid manifestation of Beardsley’s synthetic style. Firbank sharpens, exaggerates and concentrates the scent motif in the plot of the “The Artificial Princess”. It is typical for pastiche. The hair motif in Beardsley’s novel is the key to creation of an intermedial image of Venus, with an emphasis on her beauty and grandeur. Hairstyle of Firbenk’s heroines (Princess and Grand Duchess) is a paradoxical combination of everyday details and implication of philosophical category of time. The costume motif is most vividly represented in the plot of Venus’s dress. It forms her visual image, reminiscent of the plots of Italian and French paintings of the 17th–18th centuries (A. Carracci, F. Boucher). Firbenk also combines these reminiscences with the elements of decadence and the angular imagery of modernism. Beardsley’s style is based on a system of motifs and images characteristic of Art Nouveau and aestheticism of the late 19th century. In the decade leading up to 1925 Firbenk stylizes these motifs in a modernistic way, sharpening, protruding, and exaggerating them.
Współczesny spór o istotę i zakres wychowania personalistycznego w Polsce
Authors: Śliwerski Bogusław
Published: February 2023

The object of analysis is the personality education, train of thought pedagogic the most exposed of the conflict as the result of political disputes. The main problem of absence the research and specialist literature about personality education in the period of the socialism, was caused the political and ideological reasons. In the state democratic, this same, became an object of the marginality and social exclusion in public and pedagogic debate. Important is the question – why, from what reason, we are questioning personality in pedagogic and we are giving rise for formulating alternatives towards him. This situation is supporting to creating another – non personal direction in pedagogic, against contents and the structure of the social functioning.
Etyczne problemy w działalności gospodarczej spółek kapitałowych w sporcie kwalifikowanym
Authors: Pawlak Zbigniew , Smoleń Andrzej
Published: February 2023

This paper focuses on some ethical issues of companies operating in the field of competitive sports including in particular: limited liability vis-à-vis creditors of the companies that discontinued their activities, but were not subject to liquidation, nor bankruptcy petition has been filed; hampered recognisability of individual companies due to frequent changing of their names and names of teams participating in the tournaments; legal and financial status, rights and duties of contestants of these companies are underdefined; company identity is violated due to the pursuing of merger and acquisition strategy. It was decided that the above issues exemplify broader problems between labour and capital in the contemporary enterprise. Addressing of the above issues is a tough and complicated process, and sometimes simply impossible in the situation where sports have been recognised as equal sphere of business activities and where basic rules of market economy are respected also with reference to this sphere of life.
Spontaneous Pneumopericardium in a Term Newborn
Authors: Krcho Peter , Donn Steven M
Published: February 2023

We present the case of a term newborn who developed cardiopulmonary distress at 15 minutes of age secondary to a spontaneous pneumopericardium. Diagnostic and therapeutic considerations are addressed.
Legalitas Kepemilikan Atas Hasil Penambangan Asteroid di Ruang Angkasa Berdasarkan Pengaturan Hukum Internasional
Authors: Sari Alya Azalia Permata
Published: February 2023

Abstract
Asteroid mining is a proposed solution for mining the elements commonly obtained from conventional mining that we know today. However, there are no Indonesian laws and regulations, nor international agreements that directly regulate what rights will be owned by miners of space resources thus far. Without certainty about what property rights exist in the extracted resource, the incentive to extract this resource will be greatly reduced. The research method in this journal uses a statutory approach, that examines the regulations related to the legal issues raised, and conceptual approach, which is an approach method based on legal concepts related to the legal issues involved. at issue. Based on the facts found, it can be concluded that the concept of property rights exists and is recognized in the space law regime, even in the absence of territorial rights over celestial bodies, although its application to resource extraction remains a contentious issue.
Keywords: Mining, Asteroid, Property Rights, Outer Space.
 
Abstrak
Penambangan asteroid adalah solusi yang diusulkan untuk menambang elemen-elemen yang biasa didapatkan dari penambangan konvensional yang kita kenal saat ini. Namun sampai saat ini belum ada peraturan perundang-undangan Indonesia, maupun perjanjian internasional yang secara langsung mengatur mengenai hak apa yang akan dimiliki oleh penambang sumber daya ruang angkasa. Tanpa kepastian tentang hak milik apa yang ada dalam sumber daya yang diekstraksi, insentif untuk mengekstraksi sumber daya ini akan sangat berkurang. Metode penelitian dalam jurnal ini menggunakan pendekatan perundang-undangan, menelaah peraturan perundang-undangan yang bersangkutan dengan isu hukum yang diangkat, dan pendekatan konseptual, yaitu metode pendekatan berdasarkan konsep-konsep hukum yang berkaitan dengan isu hukum yang dipermasalahkan. Berdasarkan fakta-fakta yang ditemukan, dapat disimpulkan bahwa konsep atas hak milik ada dan diakui dalam rezim hukum luar angkasa, bahkan tanpa adanya hak teritorial atas benda-benda angkasa, meskipun penerapannya pada ekstraksi sumber daya tetap menjadi isu yang diperdebatkan.
Kata Kunci: Penambangan, Asteroid, Kepemilikan, Ruang Angkasa.
Perlindungan Hukum Bagi Pembeli Barang Hasil Lelang Aset Bank Syariah yang Tidak Dapat Menguasai Barang yang Telah Dibelinya Melalui Lelang oleh Bank Syariah
Authors: Harissa Monza Riviero
Published: February 2023

Abstract
Asset auctions are used by sharia banks to cover losses suffered by banks when person or company cannot cover the amount of money given by Islamic banks in financing, while the background of this study is that the author analised various cases that have occurred where the winner of the Islamic bank asset auction could not enjoy the bank assets he had won due to problems when the bank received the assets made as collateral. To analyze this problem, the author uses the Legal Research research method which aims to find answers and solutions to the legal problems faced which will later produce a prescription of what should or should be done on the issue at hand. For this study, the author will also use the statute approach, conceptual approach, and case approach to make it easier for researchers to answer the problems that will be described in this study.
Keywords: Auction, Sharia Bank, Risk
 
Abstrak
Lelang aset digunakan oleh bank syariah untuk menutupi kerugian yang diderita oleh bank ketika seseorang atau perusahaan tidak dapat menutupi jumlah uang yang diberikan oleh bank syariah dalam pembiayaan, adapun latar belakang dari penelitian ini adalah menganalisis kasus yang berkaitan dengan pemenang lelang aset bank syariah yang tidak dapat menikmati aset yang telah dimenangkannya. Untuk menganalisis permasalahan ini, digunakan metode penelitian Legal Research yang bertujuan untuk menganalisis jawaban dan solusi atas permasalahan hukum yang dihadapi yang nantinya akan menghasilkan sebuah preskripsi mengenai apa yang sebaiknya atau seyogianya dilakukan atas isu yang dihadapi. Untuk penelitian ini, digunakan pendekatan masalah yaitu statute approach dan conceptual approach untuk mempermudah menjawab permasalahan-permasalan yang akan dijabarkan dalam penelitian ini
Kata Kunci: Lelang, Bank Syariah, Risiko
Kedudukan Surat Edaran Menteri Dalam Hierarki Peraturan Perundang-Undangan
Authors: Yusdheaputra Wafa
Published: February 2023

Abstract
A Ministerial Circular is a legal product that often issued by the Minister to clarify a matter or an event that has not been regulated. In Law Number 12 of 2011 concerning the Formation of Legislative Regulations as amended by Law Number 15 of 2019, there is absolutely no mention of a Circular as a Legislation. This then raises questions among the public regarding how the position and the binding strength compared with statutory regulations according to Law no. 15 of 2019. The purpose of this study is to analyze and find out how the position of Ministerial Circular Letters in the hierarchy of laws and regulations, using normative juridical legal research methods. The result of the research is that Ministerial Circular Letters cannot be classified as statutory regulations but only in the form of policy rules because of their non-regulating nature and more of an administrative decision.
Keywords: Minestrial Circular, Legislations, Policy Rules, Discretion.
 
Abstrak
Surat Edaran Menteri merupakan salah satu produk hukum yang kerap diterbitkan oleh Menteri sebagai lembaga eksekutif guna memperjelas suatu hal atau terhadap suatu peristiwa yang belum diatur atau peraturan perundang-undangan tidak memberi pilihan. Dalam Undang-Undang Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan sebagaimana telah diubah oleh Undang-Undang Nomor 15 Tahun 2019, sama sekali tidak menyebutkan adanya Surat Edaran sebagai Peraturan Perundang-undangan. Hal ini kemudian menimbulkan pertanyaan di kalangan publik terkait bagaimana kedudukan dan kekuatan mengikatnya apabila dibandingnkan dengan peraturan perundang-undangan menurut UU No. 12 Tahun 2011 jo. UU No. 15 Tahun 2019. Tujuan penelitian ini guna menganalisa dan mengetahui bagaimana kedudukan Surat Edaran Menteri dalam hierarki peraturan perundang-undangan, dengan menggunakan metode penelitian hukum yuridis normatif. Hasil penelitian adalah bahwa Surat Edaran Menteri tidak dapat diklasifikasikan sebagai peraturan perundang-undangan namun hanya berupa aturan kebijakan karena sifatnya yang tidak mengatur dan lebih kepada putusan yang bersifat administratif.
Kata Kunci: Surat Edaran Menteri, Peraturan Perundang-Undangan, Aturan Kebijakan, Diskresi.
Pertanggungjawaban Tukang Gigi dalam Praktik yang Merugikan Konsumen
Authors: Hidayat Dzaka Ananda
Published: February 2023

Abstract
Dental Artisans is a job that has been widely practiced in Indonesia, dental artisans are an alternative for Indonesian people who want to take care of their teeth at a low cost, as many dental artisans in Indonesia practice that can be done in various ways, ranging from making dentures, installing teeth. fakes and others which are also commonly done by dentists, but due to the lack of experience possessed by dental artisans, there are many victims who arise for the services performed by dental artisans, and in this case it must be classified which one is a loss. experienced by consumers and not, and because the practice of dental artisans is limited to the Regulation of the Minister of Health Number 39 of 2014 concerning Guidance, Supervision, and Licensing, Dental Work, also makes dental artisans practice outside of this authority on the basis of taking advantage.
Keywords: Dental Artisans, Qualification of Consumer Loss, Accountability
 
Abstrak
Tukang gigi merupakan pekerjaan yang sudah banyak berpraktek di Indonesia, tukang gigi menjadi salah satu alternatif bagi masyarakat indonesia yang ingin merawat gigi dengan biaya yang murah, sebagai tukang gigi yang banyak di indonesia praktek yang bisa dilakukan bermacam-maca, mulai dari peembuatan gigi palsu, memasang gigi palsu dan lain-lain yang juga biasa dilakukan oleh dokter gigi, akan tetapi dikarenakan kurangnya pengalaaman yang dimiliki oleh tukang gigi, membuat banyak sekali korban yang timbul atas jasa yang dilakukan oleh tukang gigi, dan dalam hal ini harus dapat di klasifikasikan mana yang merupakan kerugian yang dialami oleh konsumen dan tidak, dan dikarenakan prakter tukang gigi terbatas hanya pada Peraturan Menteri Kesehatan Nomor 39 Tahun 2014 tentang Pembinaa, Pengawasan, dan Perizinan, Pekerjaan Tukang gigi, membuat juga tukang gigi melakukan praktik diluat kewenangan tersebut dengan dasar untuk mengambil keuntungan.
Kata Kunci: Tukang Gigi, Kualifikasi Kerugian Konsumen, Pertanggungjawaban
Factors Affecting Perioperative Period Renal Function in Nephrectomies
Authors: ONAY Meryem , ŞANAL BAŞ Sema , KURADA Gizem , ÖZEN Ata , KARAKOÇ Ebru , YELKEN Birgül
Published: February 2023

Patients who have had a nephrectomy usually have a history of renal dysfunction or are at risk for kidney failure due to tissue loss during surgery. In this study, our aim was to evaluate the factors affecting acute renal function in nephrectomy surgeries under general anesthesia. Demographic data of patients, case type, surgery type, duration of anesthesia, intraoperative lactate level, and postoperative complications of patients who underwent nephrectomy in our clinic were reviewed. Renal function was compared with urea, creatinine and estimated glomerular filtration rate (eGFR) levels in the preoperative (2 days before surgery) and postoperative period (day 2). The mean age of the patient was 58.2 ± 13.02 years, duration of anesthesia 166.24 ± 53.01/min, pre-operative eGFR 84.71 (67.69-90.0) mL/min/1.73 m2, and postoperative eGFR 65.09 (47.91-87.44) mL/min/1.73 m2 were respectively. When the pre- and postoperative renal functions of the patients were compared, the statistically significant results were those of urea (p: 0.01), creatinine (p:0.01), and GFR (p:0.01). The factors affecting GFR decrease were age (p:0.01) and case type (p:0.01). Increase in lactate levels in the postoperative period compared to the preoperative levels was statistically significant (p: 0.01). The increase in lactate levels was associated with complications (p: 0.001), case type (p:0.01) and surgery type (p: 0.01). Conclusions: The incidence of acute renal failure is increasing in nephrectomy surgeries, especially in radical ones. Age and case type are also the most important parameters to be consider.
Diphtheria and the AB Toxin Group
Authors: Pembroke Billy , Will Robert C. , Madhav Archana , Shetty Vignesh , Mutreja Ankur
Published: February 2023

AB toxins have historically been associated with significant morbidity, mortality through infections such as botulinum, anthrax, cholera, and diphtheria. These AB toxin-mediated diseases remain prevalent in low and middle income countries, with intermittent outbreaks of Shiga toxin-producing Escherichia coli (STEC) or whooping cough by Bordetella pertussis in high-income countries. These reports warrant an investigation to better understand the distinct characteristics of AB toxins derived from different pathogens. As toxigenic pathogens broaden their scope and diversity, it amplifies the complexity of the problems posed by their AB toxins. Here, we discuss the history, structure and characteristics of key AB toxins, and report on historical and ongoing research on these toxins. We also explore research avenues that hold great promise in potentially improving clinical management of toxin-mediated diseases in the future.
Approximate Numerical Procedures for the Navier-Stokes System Through the Generalized Method of Lines
Authors: Botelho Fabio
Published: February 2023

This article develops applications of the generalized method of lines to numerical solutions of the time-independent, incompressible Navier-Stokes system in fluid mechanics. We recall that for such a method, the domain of the partial differential equation in question is discretized in lines (or more generally in curves), and the concerning solutions are written on these lines as functions of the boundary conditions and the domain boundary shape.
The Dawning of a New Enterprise: RNA Therapeutics for the Skin
Authors: Kieser Rachel , Khan Shaheerah , Bejar Nada , Kiss Daniel
Published: February 2023

Despite being under development for decades, RNA therapeutics have only recently emerged as viable platform technologies. The COVID-19 mRNA vaccines have demonstrated the promise and power of the platform technology. In response, novel RNA drugs are entering clinical trials at an accelerating rate. As the skin is the largest and most accessible organ, it has always been a preferred target for drug discovery. This holds true for RNA therapies as well, and multiple candidate RNA-based drugs are currently in development for an array of skin conditions. In this mini review, we catalog the RNA therapies currently in clinical trials for different dermatological diseases. We summarize the main types of RNA-related drugs and use examples of drugs currently in development to illustrate their key mechanism of action.
Pelaksanaan Pengelolaan Sampah Plastik di Sungai Bengawan Solo oleh Dinas Lingkungan Hidup Kota Surakarta
Authors: Aulia Baharrudy Isa , Triwahyudi Pius
Published: February 2023

This study aims to determine the implementation of plastic waste management in the Solo River by the Surakarta City Environment Agency. This type of legal research is non-doctrinal or empirical. It is descriptive, with a qualitative approach stated by respondents in writing or verbally and real behavior. The way to collect legal material through field research is observation, interview, documentation and literature study using primary and secondary law data. Qualitative analysis, from the reduction of data and presentation of data that is linked so that conclusions can be drawn. Conclusion of the results of the discussion in response to the problem of this study, the Surakarta City Environmental Agency has made several efforts in the management of plastic waste in the Bengawan Solo River as an effort to conserve the river from garbage pollution and the implementation of the management of plastic waste which is carried out through several work programs including the establishment of river working groups , the formation of labor-intensive and outreach to the people of the City of Surakarta.
Implementasi Kebijakan Ruang Terbuka Hijau Publik di Kota Surakarta dalam Mewujudkan Pembangunan Berkelanjutan
Authors: Ramadhanty Auliya Istiqomah , Rachmi Handayani I Gusti Ayu Ketut
Published: February 2023

Penelitian ini bertujuan untuk mengetahui mengenai bagaimana implementasi kebijakan ruang terbuka hijau publik di Kota Surakarta dalam mewujudkan pembangunan berkelanjutan. Penelitian hukum ini merupakan jenis penelitian hukum empiris yang bersifat deskriptif. . Jenis data primer meliputi bahan hukum primer dan sekunder. Teknik pengumpulan data yang digunakan adalah wawancara yang dilakukan di Dinas Lingkungan Hidup Kota Surakarta serta studi kepustakaan. Teknik analisis yang digunakan adalah metode analisis data kualitatif dengan model interaktif. Hasil penelitian menunjukkan bahwa, pertama implementasi kebijakan terkait ruang terbuka hijau publik di Kota Surakarta belum berjalan dengan optimal, banyak hal yang harus lebih dikembangankan terkait permasalahan Ruang Terbuka Hijau pulik di Kota Surakarta. Pproporsi Ruang Terbuka Hijau publik di Kota Surakarta saat ni adalah 8,47%, dimana hal tersebut belum sesuai dengan Undang-Undang nomor 26 Tahun 2007, Peraturan Daerah Kota Surakarta Nomor  Tahun 2012, dan Peraturan Daerah Kota Surakarta Nomor 10 Tahun 2015 yaitu sebesar 20% dari luas wilayah kota. Kedua, masih banyak terdapat khambatan yang dialami Ketika dalam mengimplementasikan kebijakan terkait ruang terbuka hijau publik di Kota Surakarta dalam mewujudkan pembangunan berkelanjutan.
Pelaksanaan Pengawasan Penyelenggaraan Reklame di Kota Semarang oleh Dinas Penataan Ruang Kota Semarang terhadap Lingkungan
Authors: Rizky M. Islahul , Waluyo Waluyo , Najicha Fatma Ulfatun
Published: February 2023

This study aims to reveal and analyze the implementation of supervision of billboard organizers in Semarang City by the Spatial Planning Office of Semarang City and analyze the efforts made by the Government of Semarang City in order to improve order in Semarang City. The type of research conducted by the author is empirical legal writing. The results of field data and interviews, the implementation of supervision of the implementation of billboards in the City of Semarang by the Spatial Planning Service is not perfect from its implementation in the field based on Regional Regulation Number 4 of 2019 concerning Billboards, then seen from the obstacles in carrying out supervision of billboard organizers and view from the Semarang City environment , which resulted in delays in the implementation of the supervision, so that the implementation is not perfect.
Peran Dinas Lingkungan Hidup Kabupaten Pacitan dalam Implementasi Peraturan Daerah tentang Pengelolaan Sampah di Kabupaten Pacitan
Authors: Ayuningtiyas Desma Dwi , Hermawan Sapto
Published: February 2023

Penulisan hukum ini menjelaskan tentang Implementasi Peraturan Daerah Kabupaten Pacitan Nomor 1 Tahun 2011 tentang Pengelolaan Sampah Oleh Dinas Lingkungan Hidup Kabupaten Pacitan dalam Mewujudkan Kebersihan Kota. Permasalahan penyelenggaraan pengelolaan sampah yang terjadi di Kabupaten Pacitan yaitu karena adanya pertambahan penduduk dan pola konsumsi masyarakat menimbulkan bertambahnya volume, jenis dan karakteristik sampah yang beragam sehingga perlu adanya pengelolaan sampah yang tepat. Penelitian ini merupakan penelitian normatif. Penelitian ini dilakukan dengan mengolah data-data primer dan sekunder. Data primer diperoleh melalui wawancara dengan Pegawai Negeri Sipil Dinas Lingkungan Hidup Kabupaten Pacitan bagian pengelolaan sampah dan data sekunder yang diperoleh melalui pengkajian pustaka-pustaka yang ada, yang berhubungan dengan penelitian ini.
Pengaruh Pengelolaan Kelas dan Minat Belajar Terhadap Hasil Belajar IPS Siswa Kelas V SD Negeri Se-Kecamatan Kutowinangun Tahun Ajaran 2021/2022
Authors: Munawaroh Fikriatul , Chamdani Muhamad , Ngatman Ngatman
Published: February 2023

Pengelolaan kelas dan minat belajar merupakan salah satu faktor yang dapat memengaruhi hasil belajar. Penelitian ini bertujuan untuk 1) mengetahui pengaruh pengelolaan kelas terhadap hasil IPS, 2) mengetahui pengaruh minat belajar terhadap hasil belajar IPS. 3) mengetahui pengaruh pengelolaan kelas dan minat belajar secara simultan terhadap hasil belajar IPS. Populasi sebanyak 614 siswa dengan sampel sebanyak 273 siswa. Teknik pengambilan data dilakukan menggunakan angket yang diterapkan pada variabel pengelolaan kelas dan minat belajar dan instrumen tes diterapkan pada variabel hasil belajar. Penelitian ini menggunakan desain penelitian kuantitatif korelasi dengan metode analisis regresi berganda. Teknik analisis yang digunakan yaitu analisis regresi berganda, uji F, uji T, analisis korelasi berganda, sumbangan efektif, koefisien determinan, dan sumbangan relatif. Hasil penelitian ini menunjukkan bahwa 1) pengelolaan kelas berpengaruh terhadap hasil belajar IPS dengan nilai t hitung sebesar t hitung=3,166 >=1,968, 2) minat belajar berpengaruh terhadap hasil belajar IPS dengan nilai t hitung sebesar  t hitung= 16,131 >  t tabel = 1,968, dan 3) pengelolaan kelas dan minat belajar berpengaruh terhadap hasil belajar IPS dengan nilai F hitung sebesar 965,673 > 3,029 (F tabel). Penelitian menghasilkan kesimpulan bahwa ada pengaruh antara pengelolaan kelas dan minat belajar secara parsial dan simultan terhadap hasil belajar IPS siswa kelas V SD Negeri se-Kecamatan Kutowinangun tahun ajaran 2021/2022.

 
Analisis Motivasi Belajar Siswa Kelas IV pada Pembelajaran Tematik Secara Tatap Muka di SD Negeri 1 Kutoarjo Tahun Ajaran 2021/2022
Authors: Pratiwi Dita , Susiani Tri Saptuti , Ngatman Ngatman
Published: February 2023

Pembelajaran tematik secara tatap muka yang mulai dilaksanakan kembali di semester genap tahun ajaran 2021/2022 memengaruhi motivasi belajar siswa. Dengan menggunakan pendekatan kualitatif studi kasus, tujuan yang ingin di capai melalui penelitian ini adalah untuk menganalisis motivasi belajar siswa kelas IV pada pebelajaran tematik secara tatap muka dan menganalisis kendala yang dihadapi dalam meningkatkan motivasi belajar siswa kelas IV pada pembelajaran tematik secara tatap muka. Hasil penelitian menunjukkan bahwa motivasi belajar siswa mencapai hasil 88% atau berkategori baik dan siswa lebih termotivasi selama pembelajaran tematik secara tatap muka. Walaupun sudah mencapai hasil dengan kategori baik, masih ditemukan kendala dalam meningkatkan motivasi belajar siswa, yaitu motivasi belajar siswa yang tidak menentu dan penggunaan media pembelajaran yang belum maksimal.
CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
Authors: Grigoriadis Kristiana , Huebner Ariana , Bunkum Abigail , Colliver Emma , Frankell Alexander M. , Hill Mark S. , Birkbak Nicolai J. , Swanton Charles , Zaccaria Simone , McGranahan Nicholas
Published: February 2023

Intra-tumour heterogeneity provides the fuel for the evolution and selection of subclonal tumour cell populations. However, accurate inference of tumour subclonal architecture and reconstruction of tumour evolutionary history from bulk DNA sequencing data remains challenging. Sequencing and alignment artefacts cannot be distinguished from real cancer somatic mutations and errors in the identification of copy number alterations or complex evolutionary events (e.g. mutation losses) affect the estimated cellular prevalence of mutations, leading to errors in mutation clustering and phylogenetic reconstructions. In this paper we present a new computational framework, CONIPHER (COrrecting Noise In PHylogenetic Evaluation and Reconstruction), that accurately infers subclonal structure and phylogenetic relationships from multi-sample tumour sequencing, accounting for both copy number alterations and mutation errors. CONIPHER outperforms similar methods on simulated datasets, and in particular scales to a large number of tumour samples and clones. As such, CONIPHER enables automated phylogenetic analysis which can be effectively applied to large sequencing datasets generated with different technologies.
Scribble deficiency promotes colon inflammation by inhibiting autophagy-dependent oxidative stress elimination
Authors: Sun Xia , Lu Liying , Wang Kai , Song Lele , Wu Yanjun , Wang Xinyu , Song Yanan , Zhan Lixing
Published: February 2023

Background：Scribble, a master scaffold in apical-basal polarity, proliferation and epithelial integrity. Current knowledge about the biological function of Scribble in the colonic epithelial plasticity/regeneration during intestinal inflammation is limited. Here, we explore the unexpected role of Scribble in IBD.
Results：We showed that Scribble level are decreased in IBD patients and mice with DSS-induced colitis. Our study suggested that ScribΔIEC mice develops severe acute colitis by disrupting epithelial barrier integrity and impairing the function of crypt stem cells. Here, we confirmed that Scribble KO may contribute to the dysregulated autophagy level due to the deletion of Atg16L1, and led to an accumulation of mitochondrial ROS both in intestinal stem cells and epithelial cells. Mechanistically, Scribble suppressed the process of autophagy by modulating the stability of caspase-dependent degradation of Atg16L1 by directly interacting with Atg16L1 in a LRR domain-dependent manner in IECs. Moreover, when ScribΔIEC organoids were treated with autophagy activator Rapa, the ROS signal in the organoids was significantly reduced, which indicates that the specific association of Scribble and Atg16L1 are crucial signaling molecules in oxidative stress response of intestinal inflammation. In addition, further study indicates that dietary sphingomyelin alleviates DSS-induced colitis by increase the expression of Scribble, which suggests that Scribble may be the critical marker of IBD.
Conclusions：Our study firstly shows that Scribble deficiency maybe associated with the dysregulated autophagy and impaired maintenance of colonic stemness, and it may be a target for diagnosis and treatment of inflammatory bowel disease.
Safety attitude, professional values and coping ability predicted the knowledge, attitude and practice of nursing interruptions amomg Chinese nursing managers: A cross-sectional study
Authors: Dong Xiaoqian , Ding Siqing , Xie Jianfei , Wang Sha , Liu Min , Zhang Chun , Gan Gang , Cheng Andy SK
Published: February 2023

Background: Nursing interruptions bring the negative aspects, such as interfered with the attention and prospective memory, increased workload and likelihood of cognitive distractions, decreased work efficiency and experience, thereby increasing the risk of committing adverse nursing events. To determine levels of knowledge, attitude and practice regardingnursing interruptions and its factors among Chinese nursing managers.
Methods: A nationwide cross-sectional descriptive survey. We used a multistratified random sampling method to obtain samples by online questionnaires from five provinces in China. Totally 1,113 nursing managers from 31 hospitals in China were recruited. The appropriate indicators were used for descriptive statistics, and t test, analysis of variance, Pearson’s correlation analysis and multiple linear regression were used to analyse the influencing factors. A STROBE checklist was used to report the results.
Results: The overall mean score of nursing interruptions was 26-123 (83.10±15.67), and the level was medium. Professional values, safety attitude, and coping ability had significant positive correlation with nursing interruptions (p < 0.001), and theytogether with departments and the highest education level were positive predictors(p < 0.05). These predictors explained 29.3% of the variance. Department and employment years were negative predictors of knowledge and attitude, respectively (p < 0.05).
Conclusions: Chinese nursing managers had a moderate level of knowledge, attitude, and practice of nursing interruptions. Professional values, safety attitude, coping ability, highest level of education, position, department and employment yearswere predictors.
In vivo Brain Estrogen Receptor Expression By Neuroendocrine Aging And Relationships With Gray Matter Volume, Bio-Energetics,
and Clinical Symptomatology
Authors: Mosconi Lisa , Jett Steven , Nerattini Matilde , Andy Caroline , Yepez Camila Boneu , Zarate Camila , Carlton Caroline , Kodancha Vibha , Schelbaum Eva , Williams Schantel , Pahlajani Silky , Loeb-Zeitlin Susan , Havryliuk Yelena , Andrews Randolph , Pupi Alberto , Ballon Douglas , Kelly James , Osborne Joseph , Nehmeh Sadek , Fink Matthew , Berti Valentina , Matthews Dawn , Dyke Jonathan , Brinton Roberta Diaz
Published: February 2023

17β-estradiol,the most biologically active estrogen, exerts wide-ranging effects in brain through its action on estrogen receptors (ERs), influencing higher-order cognitive function and neurobiological aging. However, our knowledge of ER expression and regulation by neuroendocrine aging in the living human brain is limited. This in vivo multi-modality neuroimaging study of healthy midlife women reveals progressively higher ER density over the menopause transition in estrogen-regulated networks. Effects were independent of age and plasma estradiol levels, and were highly consistent, correctly classifying all women as being post-menopausal or not. Higher ER density was generally associated with lower gray matter volume and blood flow, and with higher mitochondria ATP production, possibly reflecting compensatory mechanisms. Additionally, ER density predicted changes in thermoregulation, mood, cognition, and libido. Our data provide evidence that ER density impacts brainstructure, perfusion and energy production during female endocrine aging, with clinical implications for women’s health.
A new view on the metrology of digital twin objects of production processes on the example of assessing the serviceability of metal cutting tools
Authors: Shvedenko Vladimir , Shchekochikhin Oleg
Published: February 2023

The basic property of the digital twin is its metrology, which includes methods and means of ensuring the uniformity of measurements and achieving their required accuracy. The purpose of this study is to justify the basic functions of digital twin metrology - measuring and correcting an "exact" copy of a physical object, with justification of the frequency of this measurement based on the emerging risks of disturbing the functionality of the technical object. The methodology of using object-process data model when creating digital twins is presented. Methodology for calculating failure probability of technical object depending on probabilistic characteristics of its individual properties is shown. The variants of periodicity of measurements of changing properties of technical object to ensure the adequacy of digital model taking into account the probability of failure occurrence are shown. The variant of estimation of economic efficiency of digital twin of technical object is considered. The scheme for determination of economically justified period of technical object operation taking into account probability of failure occurrence is shown. The article considers an example of creation of digital model of metal-cutting tools and control process of wear of their cutting edges. The presented mathematical model allows virtual prediction of the tool cutting edge wear and probability of failure occurrence. The inverse relations between the physical object and the mathematical model allow to correct the empirical coefficients.
Adsorption and Diffusion Properties of Tobacco Composition and Additive: A Multiscale Theoretical Study
Authors: Xia Qian , Wang Jun , Jiang Jian , Hu Anfu , Wu Jian , Lu Xinbo , Xiao Weiqiang , Zhou Guojun , Zhuang Guilin
Published: February 2023

Unveiling the influence effects of H2O and others (propylene glycol, glycerol and nicotine) on adsorption and diffusion in tobacco is of great importance in cigarette industry while being a challenge issue under three different factors (temperature, concentration and aperture size). Herein, via first-principles density functional theory ( DFT ) simulations, it is found that H2O tends to be adsorbed on O-top sites rather than H-top sites due to the stronger H-bond attraction, on which existed H2O is also easy to desorb because of the weak physical adsorption. Moreover, via molecular dynamics ( MC ) calculations, under 300 K − 500 K range, the diffusion of H2O and other components increases as increasing temperature due to the intensified thermal exercise. Regarding effect of concentration (4% − 14%), with upgrading the concentration, the diffusion property elevates and then decreases for H2O and others, which may be related to the stability of the system caused by H-bonds and the free accommodation space of cellulose structure. Focused on influence of aperture size, as the pore size increases, the diffusion of H2O and others increases significantly due to the expansion of the free space and the diffusivity of H2O is higher than that of others on account of smaller structural form.
Language disorders as comorbidity in enuretic children: prevalence and impact on treatment
Authors: FERRARA Pietro , CAMMISA Ignazio , GALLO Giorgia , Zona Margherita , MASTRICCI Rosanna , MATARRELLI Chiara , SACCO Roberto , VERROTTI Alberto
Published: February 2023

PURPOSE
Several studies have recorded an association between nocturnal enuresis (NE) and developmental delays. Language disorders are one of the main comorbidities in enuretic children, affecting therapy outcome and prognosis.
METHODS
The study was carried out within our pediatric outpatient clinic in Campus Bio-Medico University Hospital Foundation of Rome, enrolling a total of 226 enuretic children, of which 21 with a language disorder. Data concerning NE were collected through questionnaire and interview with parents and a bladder diary. The language disorders was secondary investigated. The chi-squared test was used to evaluate the correlation between therapy outcome and language disorders.
RESULTS
Our sample was composed of 226 enuretic children, with a mean age of 7.67 years. 217 children were subjected to pharmacological treatments, while 9 children, with mild clinical symptoms, did not take any drugs. It was observed that 49% of enuretic children did not respond to therapy or relapsed, while 51% responded in the first cycle. 21/226 (9%) of enuretic children had a language disorder, of which 15 subjected to pharmacological therapy: 12/15 (80%) did not respond to therapy and 3/15 (20%) responded (p = 0.024).
CONCLUSIONS
Language disorders could impact NE therapy response, underlying the influence of comorbidities and the importance of a global assessment in enuretic children.
Allogenic stem cells for anal Crohn’s fistula: treating early improves the deep response rate
Authors: Fathallah Nadia , Siproudhis Laurent , Akaffou Mélissa , Haouari Mohamed Amine , Landemaine Amandine , Pommaret Elise , Spindler Lucas , Brochard Charlène , Bouguen Guillaume , Parades Vincent
Published: February 2023

Purpose:
The aim of this study was to evaluate the real-life clinical and radiological efficacy of darvadstrocel injection into complex perianal fistulas in Crohn’s disease. Secondary endpoints were to assess symptomatic efficacy, outcomes and factors associated with complete combined clinical-radiological response (deep response).
Methods:
After marketing the product in France, all patients treated consecutively were included. A complete clinical response was defined by a complete closure of all external openings with no discharge on pressure. A partial response was defined by closure of ≥ 50% of external openings with no discharge on pressure. A complete radiological response (MRI), evaluated at least after six months of follow-up, was defined by a completely fibrotic sequela without abscess.
Results:
Forty-three patients were included (M/F: 22/21, median age 37 [26-45] years). The fistulas of all patients were already drained with seton(s) and were on biologic treatment. After a median follow-up of 383 [359-505] days, 28 (65%) patients showed a clinical response (22 complete and 6 partial). Only 16 (37%) achieved a deep response. The PDAI decreased significantly after treatment: 39 (91%) patients reported symptomatic improvement in terms of discharge, pain, and induration, and 28 (65%) no longer had any perineal symptoms. Only a short history of Crohn’s disease < 3 years was significantly associated with deep response (OD 4.5 [1.0-19.1], p = 0.04).
Conclusion:
Darvadstrocel injection resulted in a clinical response for two thirds of patients and deep response for one third. A shorter duration of Crohn’s disease was associated with deep response.
Health, wellbeing and nutritional impacts for students and families after two years of government-funded school lunches in low advantage schools in Aotearoa New Zealand.
Authors: McKelvie-Sebileau Pippa , Swinburn Boyd , Glassey Rachael , Leach David Tipene , Gerritsen Sarah
Published: February 2023

Objective: In 2020, a government-funded school lunch program was introduced in a quarter of New Zealand schools selected based on high levels of socio-economic barriers. We report family (whānau), student and principal perspectives on the impact of the first two years of this healthy school lunch program.
Methods: We conducted five focus groups (2 with secondary students and 3 with family members) and four school principal interviews. Thematic analysis was carried out to develop themes describing the health, wellbeing and nutritional impact of the program. Participating schools represent a range of contexts: primary and secondary, and schools using on-site kitchens and cooks or schools choosing to receive meals delivered by external caterers.
Results: Family participants were 82% Indigenous Māori and self-identified as having ‘borderline’ (73.5%) or no financial security (8.8%). Seven positives themes were identified: improved food security, enhanced equity, increased appreciation of healthy foods for students, enhanced mana (wellbeing) for all, reduced financial hardship and stress for families, opportunities for nutritional learning and that appreciation and uptake happen over time. Four negative impact themes were identified: low uptake that created food waste, perception that healthy food is not palatable for students, lack of knowledge of the program and loss of agency for students.
Conclusions: This is the largest intervention in nutrition and food security for children ever to be introduced in New Zealand. The first two years have resulted in important wellbeing and financial benefits for students and families involved, particularly when the school environment promotes uptake. More involvement of students and family members is essential.