bluuebunny/crossref_metadata_2025 huggingface dataset:
Online Radyoterapi Bilgilendirme Aplikasyonu
Authors: Yakar Melek , Etiz Durmuş , Kütri Deniz , Duruer Kerem , Bozdoğan Özge
Published: September 2024

Bu çalışmanın amacı, hastalara radyoterapi (RT) uygulanan cihazın arızası, tedavi süresi, tedavi zamanı hakkında ve hastalığa özgü bilgi vermektir. Kliniğimizde tedavi ettiğimiz iki eksternal (lineer hızlandırıcı), bir internal (brakiterapi) RT cihazı ve RT planlamasında kullanılan bilgisayarlı tomografi (BT) simülatörünün (çalışıyor/bakım altında/arızalı) durumu hakkında gerçek zamanlı bilgi sağlanmıştır. Uygulamayı kullanan 151 vakaya uygulama memnuniyetine ilişkin 32 soruluk bir anket uygulanmış ve RT alan hastalarda uygulamanın ulaşım süresine, maliyetine ve hastanın tedaviye uyumuna katkısı araştırılmıştır. 151 hastanın 117'si (%77,5) küratif RT ve 34'ü (%22,5) palyatif RT almıştır. Ortanca yaş 55'tir (min:28, maks:80). 102 (%67,5) hasta, uygulamanın kendilerine yolda ve/veya seyahat masraflarında zaman kazandırdığını belirtmiştir. Sorulan sorular arasında en yüksek puanları "Uygulamanın kullanımı hakkında yeterince bilgi sahibiyim", "Uygulamayı sürdürülebilir buluyorum" ve "Uygulamayı tavsiye ediyorum" soruları almış olup ortalama puan 4,58 (min:0 , maks: 5)’tür. Radyasyon onkolojisindeki uygulamalar, RT hastalarında özellikle gereksiz hasta transportunu önlemek için hasta bilgisi sağlama ve cihaz bilgisi paylaşma konusunda eksiktir. RT cihazları hakkında anında bilgi ve hastanın tanısına özgü bilgi, hastanın tedavi uyumu için çok önemlidir ve bunu iyileştirmek için uygulamalar geliştirilmelidir.
Efektivitas penerapan strategi pembelajaran diferensiasi melalui literasi digital terhadap mata pelajaran Pendidikan Pancasila (SMP Negeri 2 Bandung)
Authors: Agustina Arien Minawati , Sapriya Sapriya , Sundawa Dadang
Published: September 2024

ABSTRAK
Beragam potensi yang dimiliki oleh peserta didik menimbulkan adanya kebutuhan untuk memenuhi minat serta bakat dalam memproses pengetahuan secara optimal. Kemajuan zaman yang didukung dengan era revolusi industri 4.0 menciptakan masifnya penggunaan media digital termasuk kepada kegiatan pembelajaran. Hal ini memberikan urgensi dalam memberikan kompetensi kepada peserta didik untuk menguasai literasi digital. Maka dari itu dalam kurikulum merdeka belajar   menciptakan salah satu terobosan melalui pembelajaran yang interaktif dan tepat sasaran terhadap potensi peserta didik yaitu diperoleh dengan penerapan strategi pembelajaran diferensiasi. Penelitian ini bertujuan untuk menelaah strategi pembelajaran diferensiasi pada mata pelajaran pendidikan pancasila sebagai rancangan pembelajaran yang menyesuaikan karakteristik masing-masing peserta didik dengan berlandaskan kepada nilai-nilai pancasila. Pendekatan kualitatif melalui studi kasus dilaksanakan terhadap SMP Negeri 2 Bandung sebagai sekolah penggerak Angkatan pertama dengan berbasis digital. Hasil yang diperoleh menunjukan bahwa peran strategi pembelajaran diferensiasi yang digunakan guru dalam mata pelajaran pendidikan membangun semangat peserta didik untuk berperan aktif dan inovatif pada kegiatan pembelajaran. Penggunaan perangkat ajar berbasis digital pada setiap proses pendidikan menumbuhkan kompetensi peserta didik dalam menguasai literasi digital sehingga tingkat prestasi akademik maupun non-akademik pada peserta didik memperoleh hasil yang memuaskan dan sangat baik
Kata kunci: diferensiasi, literasi digital, pendidikan pancasila
Consciousness as an antinomy (antinomy of the concept of consciousness and the philosophy of artificial intelligence)
Authors:   Institute of Philosophy, Russian Academy of Sciences, Morkina Julia
Published: September 2024

The paper shows that the reasons for the contradictions existing in the philosophy of artifi­cial intelligence (AI) are rooted in the lack of general philosophical foundations reflection. Among such foundations are the concepts of consciousness and “other consciousness”. Vari­ous approaches to these problems have been analyzed. A logical and methodological recon­struction of the of different approaches to the problem controversy of AI and consciousness is investigated. The critique of thought experiments used in the philosophy of consciousness and AI is given. A significant methodological difference between such experiments and Galileo’s experiment is demonstrated. Galileo’s experiment is a classic case of a successful thought experiment that gave an objective result. In the framework of conceptualizing and correlating the concepts of consciousness, “I” and the Other epistemological gaps inevitably emerge caused by qualitative differences in phenomenological manifestations and ways of conceptualizing the spheres of reality that need to be correlated with each other. The pa­per shows that an epistemological gap is inevitably present between the external (including verbal) behavior of the Other and its interpretation by the observer as manifestations of cer­tain internal contents of the consciousness of the Other. Moreover, phenomenological mani­festations for a person of his own consciousness and manifestations of the consciousness of the Other (including a verbal description of contents of consciousness) are not theoreti­cally correlated. The antinomy of the concept of consciousness is shown as impossibility of concluding its presence or absence in the system (“I”, Other, AI) when using purely philosophical (theoretical) methods of reasoning. The concept of consciousness as well as ideas about the consciousness of the Other, however, are necessary for practical activity and communication, that’s why a person uses practical ways of conceptualizing consciousness including intuitive perception, empathy, attribution, etc.
Enactivist approach as a way out of the “trap of cognitivism”: rehabilitation of subjectness
Authors:   South Ural State Humanitarian and Pedagogical University, Borisov Sergey
Published: September 2024

The article substantiates the importance of the subjectness position in the study of cognitive processes. The subject cannot be either eliminated or considered as a mere “carrier” and “mediator” of cognitive abilities; it is necessary to study the whole variety of subjective ex­perience and the possibilities of its empirical fixation and measurability discovered by phe­nomenology. The article argues that the radical separation of cognitive processes from con­sciousness creates a kind of explanatory gap in scientific theories. According to the author, the “trap of cognitivism” arises if the cognitive process is viewed as the solution of predeter­mined tasks (assigned to the system from the outside), where the mind is essentially a cogni­tive unconscious, which deepens the gap between “computational” and phenomenological mind and leaves no room for subjectness. The article proves the productivity of the enac­tivist approach from the position of coherence of the concept of mind as a dynamic system and phenomenological explanation of the experience of subjectness, since autonomous agents create their own cognitive domains, which allows them to endow information with new meanings and perform situational actions relevant to the environment.
Truth and utility in the technical worldview
Authors:   Samara National Research University, Nesterov Alexander
Published: September 2024

The current state of the technical development of mankind can be characterized as a trans­ition to the third artificial environment: the first artificial environment manifests itself in energy processing machines, the second – in information processing machines, the third – in autonomous artificial agents that recieve epistemic and practical access access to reality comparable to human. The conceptual apparatus of describing the problems of interaction between man and the environment, the relationship between technology and science, which is located in the philosophy of technology and in general systemic philosophy, dates back to the New Age and is focused on the state of affairs created in the first artificial habitat. Questions about goal-setting, the image of the future, responsibility that arise when using in­formation processing machines run into the theoretical lack of elaboration and opacity of the epistemic and praxeological practices of the second and third habitats, the confusion of ontological orders, the conditions for the possibility of reference, the misunderstanding of the constitutive role of a person as a subject, uniting heterogeneous layers of reality. A significant current problem of philosophical knowledge is the lack of a unified, synthetic model of cognition and activity adequate to the challenges of the second and third artificial habitats. The purpose of the study is to show the ratio of the categories of truth and utility used to fix and evaluate expedient scientific and technical activities within the framework of the philosophy of technology and the “technical worldview” (P.K. Engelmeyer). The re­search method is a comparative analysis of the works of the classics of the philosophy of technology against the background of the reconstruction of the spiral of cognition and ac­tivity carried out by means of general semiotics. The results of the study fix the state of af­fairs, according to which the technical worldview contains the scientific one in its removed form, the correspondent truth of knowledge is a condition for the possibility of a useful ac­tion. The scientific novelty of the study lies in the formulation of the problem of benefit against the background of a semantic understanding of truth. Relevant to the scientific worldview, the condition-truth theory of meaning is supplemented by the condition-utility: the meaning of a statement is not only the condition under which it is true, but also the con­dition under which it is useful, that is, technically feasible. The criterion of useful truth of a theory is the efficiency of artifacts built on its explanatory schemes.
EQUIPE EDITORIAL
Authors: Marinho Rogério Ribeiro
Published: September 2024

Expediente da revista Geonorte
Unusually Large Gartner Cyst in a 30-Year-Old Female: “Case Report”
Authors: Dixit Anjani , Hood Mitesh Mohan
Published: September 2024

Introduction: Gartner cysts are typically small and asymptomatic, often discovered incidentally. The present case report describes a rare instance of a large symptomatic Gartner cyst in a 30-year-old female, highlighting the clinical implications of such a rare presentation.
Case Presentation: A 30-year-old female presented with a significant vaginal swelling that developed postpartum and persisted for three years. The cyst, measuring 9 cm, caused considerable discomfort, affecting her daily activities and quality of life. Due to financial constraints, advanced imaging was not performed. Surgical intervention was undertaken, leading to the successful removal of the cyst and resolution of symptoms. Histopathological examination confirmed the cyst as a mesonephric remnant.
Conclusion: This case highlights the importance of considering Gartner cysts in differential diagnoses for vaginal swellings, especially when they present with significant symptoms. Surgical excision proved to be an effective treatment, leading to symptom resolution and an improved quality of life for the patient.
Use of Intraoperative Cone Beam Computed Tomography and Superposition of Preoperative Data in Pediatric Maxillofacial Surgery
Authors: Rubio-Palau Josep , García-Piñeiro Andrés , Malet-Contreras Albert , Adell-Gómez Núria , Valls-Esteve Arnau , Gómez-Chiari Marta , Munuera-Cerro Josep , Muchart-López Jordi , Valls-Ontañón Adaia
Published: September 2024

Purpose Over the last years, there has been an increase of utilization of intraoperative cone beam computed tomography (ICBCT) in maxillofacial surgery. Additional superimposition of preoperative data has proven to increase accuracy and reduce the necessity of secondary surgeries. The aims of this study were to describe the ICBCT protocol, its indications and surgical revision rate, as well as to discuss its advantages and disadvantages after two-years of experience.Methods A retrospective collection of all maxillofacial procedures using ICBCT in a pediatric maxillofacial surgery department from October 2020 to October 2022 was performed. A total of 106 patients were included.Results The total revision rate was 18.87%, but only 7.55% required a surgical major revision. A specific protocol for maxilla-mandibular surgery is described. Main advantages of ICBCT were improving surgical accuracy while decreasing the need for secondary corrective surgeries, avoiding extensive approaches; good bone image quality with low radiation exposure. On the other hand, main disadvantages were elevated costs, poor soft tissue image quality and increasing operative time.Conclusions ICBCT in combination with superimposition of preoperative data could be implemented in the daily routine of maxillofacial surgeries to increase surgical accuracy.
A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls
Authors: Godefroy Valérie , Durand Anaïs , Simon Marie-Christine , Weber Bernd , Kable Joseph , Lerman Caryn , Bergström Fredrik , Levy Richard , Batrancourt Bénédicte , Schmidt Liane , Plassmann Hilke , Koban Leonie
Published: September 2024

Impulsivity and higher preference for sooner over later rewards (i.e., delay discounting) are transdiagnostic markers of many psychiatric and neurodegenerative disorders. Yet, their neurobiological basis is still debated. Here, we aimed at 1) identifying a structural MRI signature of delay discounting in healthy adults, and 2) validating it in patients with behavioral variant frontotemporal dementia (bvFTD)—a neurodegenerative disease characterized by high impulsivity. We used a machine-learning algorithm to predict individual differences in delay discounting rates based on whole-brain grey matter density maps in healthy male adults (Study 1, N = 117). This resulted in a cross-validated prediction-outcome correlation of r = 0.35 (p = 0.0028). We tested the validity of this brain signature in an independent sample of 166 healthy adults (Study 2) and its clinical relevance in 24 bvFTD patients and 18 matched controls (Study 3). In Study 2, responses of the brain signature did not correlate significantly with discounting rates, but in both Studies 1 and 2, they correlated with psychometric measures of trait urgency—a measure of impulsivity. In Study 3, brain-based predictions correlated with discounting rates, separated bvFTD patients from controls with 81% accuracy, and were associated with the severity of disinhibition among patients. Our results suggest a new structural brain pattern—the Structural Impulsivity Signature (SIS)—which predicts individual differences in impulsivity from whole-brain structure, albeit with small-to-moderate effect sizes. It provides a new brain target that can be tested in future studies to assess its diagnostic value in bvFTD and other neurodegenerative and psychiatric conditions characterized by high impulsivity.
Novel Co-culture Model of T Cells and Midbrain Organoids for Investigating Neurodegeneration in Parkinson's Disease
Authors: prots iryna , Gerasimova Elizaveta , Beenen Amke , Kachkin Daniil , Regensburger Martin , Zundler Sebastian , Blumenthal David , Lutzny-Geier Gloria , Winner Beate
Published: September 2024

Recent studies demonstrate that brain infiltration of peripheral immune cells and their interaction with brain-resident cells contribute to Parkinson’s disease (PD) pathology. To investigate an interaction of T cells and brain-resident cells in the midbrain in spatial manner, we developed a three-dimensional (3D) human model comprising stem cell-derived human midbrain organoids (hMO) and peripheral blood T cells. We demonstrated that the complex 3D structure of organoids consists of multiple midbrain-specific cell types, allowing to study T cell motility and T cell interactions with midbrain tissue in a spatially organized microenvironment. We tested different co-culture conditions and determined optimal settings for studying T cell driven effects on hMO. T cells infiltrate hMO tissue and cause neural cell loss in hMO. Our work establishes a novel 3D cell co-culture model as a promising tool to investigate the effect of the adaptive immune system on midbrain in the context of PD.
MRI changes and clinical results of low-energy semiconductor percutaneous laser disc decompression（LS-PLDD） for lumbar disc herniation in adolescents
Authors: Shiwen Li , Tianyu Hu , Valentinovich Ivanenko , Jiayuan Xu , Wenyu Wang , Quan Qi
Published: September 2024

Purpose
Low-energy semiconductor percutaneous laser disc decompression (LS-PLDD) is a minimally invasive surgical method that uses a laser to treat lumbar disc herniation. However, there is currently no clinical efficacy evaluation of this surgical method for treating lumbar disc herniation in adolescents. This study aimed to evaluate the safety and effectiveness of LS-PLDD compared with percutaneous endoscopic discectomy (PELD) in the treatment of adolescent LDH patients.
Methods
collected data on 30 adolescent LDH patients who received LS-PLDD in our center, 60 adolescent LDH patients who received PELD in our center were matched based on age and gender. The lumbar ODI and back pain VAS score before surgery and 1 week, 1 month, 3 months and 6 months after surgery were collected to evaluate the clinical outcome of two groups. And we also compared the lumbar MR imaging examinations before surgery and 3 months after surgery to observe the changes of MR of disc.
Results
The preoperative back VAS scores were (7.0 ± 0.91) and (7 ± 0.8) in the LS-PLDD group and PELD group respectively, with no significant statistical difference (P = 0.779). The VAS scores of both groups had improvement after surgery. At the last follow-up, the VAS scores of both groups were (2.0 ± 1.3) and (1.0 ± 0.8) respectively ( P < 0.01). The VAS scores of patients in PELD group improved most significantly in the first week after surgery and then gradually stabilized, while that in LS-PLDD group improved more gradually during 6 months after surgery. The preoperative ODI scores of the LS-PLDD group and PELD group were (71.1 ± 7.9)% and (68.0 ± 7.3)% (P = 0.061), at the last follow-up, the ODI scores were (28.0 ± 13.1)% and (19.0 ± 8.4)% (P < 0.01). The preoperative canal cross-sectional areas in the LS-PLDD group and PELD group were (1373.0 ± 376.6) and (1457 ± 415.9) respectively, with no significant difference between the two groups (P = 0.157), at the last follow-up, the canal cross-sectional area of the surgical segments were (1373 ± 476.6) and (1457 ± 579.1) (P = 0.227)respectively.
Conclusions
This study shows that low-energy semiconductor laser LS-PLDD is a safe and effective treatment method for adolescent LDH. It can achieve sustained retraction of the herniated disc and retain the intact structure of the disc.
Screening and Diagnosis of hemolytic anemia in North Indian population: Challenges faced
Authors: Kumar Manisha , Goel Rajeev , Debnath Ekta , Malhotra Seema , Balyan Kirti , Zaidi Mahrukh , Kargwal Vani , Yadav Reena
Published: September 2024

Background: Hemoglobinopathies are a common group of inherited disorders responsible for a significant global healthcare burden in low- and middle-income countries (LMIC).
Objective: This cross-sectional study aims to investigate epidemiological, clinical, and genetic aspects of hemolytic anemia in the antenatal population attending a tertiary care hospital in Delhi.
Material and Method: A total of 7077 antenatal women were investigated over four years, revealing an overall prevalence of Beta Thalassemia Trait (BTT) of 4.55%. The screening algorithm involved complete blood count and High-Performance Liquid Chromatography (HPLC) for the women, followed by mutation testing using Multiplex ARMS PCR for four common mutations: IVS1-5, CD 41-42, CD 8-9, and Del 619 bp, additionally ARMS PCR, MPLA, and Sanger sequencing were also used. In cases where abnormal HPLC results were found, further testing of the husbands was done to guide counseling and decisions regarding prenatal testing.
Results:IVS1-5 was identified as the most common mutation. CD 26 exhibited the lowest hemoglobin and highest HbA2 values among all mutations. The study underscores the challenges of using RBC indices, especially in cases with overlapping Nutritional Deficiency Anemia (NDA) and Hemolytic Anemia (HA). Similar challenges were observed with HbD and HbE due to their high MCV and MCH values, the algorithm for antenatal screening and diagnosis for LMIC was ascertained.
Conclusion:The study provides data on the relative distribution of HA mutation in the antenatal population and emphasizes the importance of targeted screening strategies and genetic counseling to reduce the impact of hemoglobinopathies in the region effective.
Study of Rheumatoid Arthritis in older patients: A cross-sectional study
Authors: SAH RAMESH KUMAR , Dey Aparajit Ballav , Chakrawarty Avinash , Kumar Uma , Dwivedi Sada Nand , Das Chandan
Published: September 2024

Background: Rheumatoid Arthritis (RA) is a common chronic inflammatory arthritis causing severe disability and impacting patients' physical, psychological, and social health, as well as society due to healthcare costs and decreased productivity. This study analyzes RA in older patients focusing on clinical, radiological, immunological profiles, disease activity, severity, disability, comorbidities, and the diagnostic utility of a new serum marker, 14-3-3η.
Methodology: A cross-sectional study recruited 200 arthritis patients over sixty years old and 40 controls. Anti-CCP and serum 14-3-3η levels were measured. Descriptive analysis was performed for all variables. Quantitative variables were compared using unpaired t-test or Wilcoxon Rank Sum test, and categorical variables using Chi-Square or Fisher exact test. Spearman’s correlation coefficient assessed associations between continuous variables. ROC curves determined optimal cut-off values for serum ACCP and 14-3-3η levels.
Results: The most common complaints were joint pain (100% small and large joints, 31.7%), fatigue (71.4%), myalgia (61.4%), fever (55.56%), weight loss (46.03%), neuropathy (25.4%), and PMR-like symptoms (19.05%). Impaired ADL and IADL were noted in 17.5% and 73.2%, respectively. Impaired HMSE and GDS were found in 36.5% and 41.2%, respectively.
The mean age of RA onset was 55.8 years, and the mean RA duration was 7.8 years. The mean number of joints involved was 3.6, and EMS was 28.8 minutes. TJC and SJC means were 8.6 and 2.17, respectively. The mean VAS, CRP, ESR, DAS28ESR, and DAS28CRP were 39, 6.9, 33.3, 6.12, and 2.2, respectively. Serum ACCP and 14-3-3η means were 4.4 and 2.2, respectively. Common deformities were swan neck (30.19%), ulnar deviation (20.63%), and boutonniere (19.05%).
For ACCP, a cut-off value of ≥ 0.5098 U/mL had 77.7% sensitivity and 76.64% specificity. For 14-3-3η, a cut-off value of ≥ 1.471 U/mL had 55.56% sensitivity and 54.74% specificity. Using both markers, 88.88% of RA patients were positive for one of the tests.
Conclusion: RA is prevalent in the elderly, especially in women, and is associated with impaired CGA scores and comorbidities like hypothyroidism and osteoporosis. PMR-like symptoms are common, indicating an acute onset and severe course. DMARDS remain the main treatment. Plasma 14-3-3η is a useful diagnostic marker, especially when combined with ACCP, warranting further investigation for early RA diagnosis.
Interleukin-34 orchestrates bone formation through its binding to Bone Morphogenic Proteins
Authors: Heymann Dominique , Lézot Frédéric , Munoz-Garcia Javier , Vargas-Franco Jorge , Schiavone Kristina , Keatinge Marcus T. , Young Robin , Amiaud Jérôme , Fradet Laurie , Jégou Jean-François , Yagita Hideo , Blin-Wakkach Claudine , Wakkach Abdelilah , Cochonneau Denis , Ollivier Emilie , Pugière Martine , Henriquet Corinne , Legendre Marie , Giurgea Irina , Amselem Serge , Heymann Marie-Françoise , Télétchéa Stéphane
Published: September 2024

During growth, the contribution of IL34, a ligand of MCSFR, have not been established. The aim of this work was therefore to establish these implications using two models of IL34 invalidation generated in zebrafish and mouse. Significant growth delay and hypo-mineralization of skeletal elements were observed in both models, as well as craniofacial dysmorphoses in mice. With regard to bone cells, an unexpected increase in the number of osteoclasts and an accumulation of pre-osteoblasts were observed. In vitro analyses complemented by protein binding and molecular docking studies established that IL34 interacts directly with certain Bone Morphogenetic Proteins, modulating their various activities such as the stimulation of osteoblast differentiation. A new mechanism of action for IL34 has thus been characterized, opening up new therapeutic perspectives.
Self-rated health and the risk of incident atrial fibrillation: Ansung-Ansan cohort of the Korean Genome Epidemiology Study
Authors: Lee Yonggu , Kim Jae Han , Park Jin-Kyu
Published: September 2024

Aims
The association between Self-Rated Health (SRH) and development of Atrial Fibrillation (AF) is not well studied in the general population.
Methods
We reviewed the data of 9,895 participants in the Ansung-Ansan cohort study, a community-based Korean study. SRH was categorised as “Poor”, “Fair”, or “Good”. Newly developed AF was identified using biennially performed ECGs and/or a self-rated history of physician-determined diagnoses. AF-free survival times among the SRH groups were compared using the log-rank test, and Hazard Ratios (HRs) and Confidence Intervals (CIs) were calculated using the Cox proportional hazards model. The performance of the prediction models with the SRH variable was evaluated using Harrell’s C-index.
Results
Over a median follow-up period of 11 years, 149 participants (1.5%) developed AF. Compared to the “Good” group, the “Poor” group had a higher risk of incident AF (adjusted HR 1.85; 95% CI 1.19–2.87). Old age, female sex, lower education, smoking, cardiovascular disease (hypertension, diabetes, and coronary artery disease), and inflammation were associated with “Poor” SRH. Along with SRH, age, male sex, urban residence, hypertension, and myocardial infarction were associated with a higher risk of incidental AF. Compared to a model with conventional AF risk factor, the combined model with conventional risk factors and SRH performed marginally better to predict incident AF (C-index 0.708 vs. 0.719, P = 0.058).
Conclusion
Poor SRH is independently associated with the developed of AF in a general population. However, SRH alone has a limited role in AF surveillance when combined with conventional AF risk factors.
The role of the intercondylar notch’s morphology in anterior cruciate ligament injury
Authors: KACEM Med Samih , JHIMI Ali , BAHROUN Sami , ALOUI Ala , BOUAZIZ Anis , DAGHFOUS Med Samir
Published: September 2024

Background
The relationship between anterior cruciate ligament (ACL) injury and the morphology of the intercondylar notch remains unclear. The purpose of this study was to determine which morphometric characteristics of the intercondylar notch contribute to the ACL injury using MRI images.
Methods
A retrospective study was conducted in which 107 knee joint magnetic resonance images (MRI) of healthy, active males were compared. The patients were distributed between 55 ACL-injured patients and 52 matched control subjects. A descriptive and analytical study studied the effects of the following variables on the risk of ACL injury: notch width index; notch shape index notch; notch angle, notch height index on the axial and the coronal planes (axial NWI, coronal NWI, axial NSI, coronal NSI, axial NA, coronal NA, axial NHI and coronal NHI respectively), the Blumensaat alpha angle and the shape of the notch as described by Hirtler. A receiver operating characteristic (ROC) analysis was conducted for the significative parameters to determine their cut-off values.
Results
The coronal NWI (p = 0.048, cut-off = 0.25), the axial NSI (p = 0.004, cut-off = 0.43) and the axial NA (p = 0.048, cut-off = 47°) were significant risk factors for ACL injury, the other studied parameters were not associated with increased risk of ACL injury.
Conclusions
The coronal NWI, the axial NSI and the axial notch angle are independent anatomical risk factors for ACL injury and express a narrow intercondylar notch in young active males.
Simulation of floods under the influence of effective factors in hydraulic and hydrological models using HEC-RAS and MIKE 21
Authors: Ansarifard Sara , Eyvazi Morteza , kalantari Mahsa , mohseni behrooz , Ghorbanifard Mahdi , Moghaddam Hadi Jafakesh , Nouri Maryam
Published: September 2024

Simulating floods and creating vulnerability maps are essential in urban watershed management systems. The present research aimed to simulate floods and assess floodplain risk in the Khalkai watershed located in Gilan Province, Iran. This river is characterized by extensive agricultural areas and urban areas that become flooded during most rainy seasons. Hence, investigating this topic is important. In this research, a two-dimensional hydrodynamic modeling approach was used to simulate floods with probability return periods of 50, 100, and 500 years, under the influence of GPS topographic mapping compared with DEMs extracted from satellite images. Therefore, MIKE21 and HEC-RAS 6.3 software were utilized to construct flood inundation maps and select the best model for the Khalkai watershed. The following objectives were considered in this study: 1. The impact of the roughness coefficient index and curve number was examined due to increasing simulation accuracy, so the modeling was carried out for both steady and flood flows. By examining the rate of change in the roughness coefficient index and the curve number, it was shown that these two factors vary depending on the type of flow state in the simulation. The main reasons for this difference are the flow velocity, infiltration, and flow regime in the area, which are under critical conditions due to human interventions such as bridge and wall construction, which increase the probability of significant damage. 2. The accuracy of floodplain estimation was evaluated using the abovementioned models with Sentinel satellite images taken during a 25-year flood event. The accuracy of the models used in estimating the floodplain density was subsequently assessed.
Association between the oxidative balance score and cognitive function: evidence from NHANES 2011-2014
Authors: Wei Shouxin , Yu Sijia , Lan Yunsheng , Jia Yingdong
Published: September 2024

Background
With the global aging population, the prevalence of Cognitive impairment (CI) has significantly increased. Despite extensive research, the role of oxidative stress in CI remains underexplored, with limited studies directly linking oxidative balance score (OBS) to cognitive function. This study aims to investigate the association between OBS and cognitive function using data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES).
Methods
Data from 2103 participants aged 60 years and older were analyzed in this study. OBS was calculated using 16 dietary components and 4 lifestyle factors.Cognitive function was assessed by a combination of tests such as CERAD, AFT and DSST. The association between OBS and cognitive function was assessed using logistic regression and restricted cubic spline (RCS) analyses after adjusting for confounders such as age, sex, and comorbidities.
Results
Key findings indicate a significant positive association between higher OBS and better cognitive function across all assessed domains, even after adjusting for potential confounders. Subgroup analyses revealed that this association was particularly pronounced in individuals with liver disease and stroke, suggesting that oxidative stress might have a more detrimental impact on cognitive function in these populations.
Conclusion
The present study provides strong evidence that higher OBS is significantly associated with better cognitive function in older adults. Dietary and lifestyle interventions to improve oxidative balance may be an effective strategy to protect cognitive health.
Multivalent MMP-12 inhibitors as a valuable approach to counteract the intestinal epithelial barrier impairment and inflammation in an in vitro model of obesity
Authors: Cuffaro Doretta , D'Antongiovanni Vanessa , Mangini Camilla , Salvo Clelia Di , Benvenuti Laura , Vandooren Jennifer , Macchia Marco , Antonioli Luca , Rossello Armando , Fornai Matteo , Nuti Elisa
Published: September 2024

Intestinal epithelial barrier (IEB) impairment represents a prodromal event underlying obesity and related systemic inflammation. In this context, metalloproteinase-12 (MMP-12) has been reported to increase the IEB permeability through the reduction of tight junction protein expression. Herein we report our effort to develop a small series of MMP-12 inhibitors as potential agents able to counteract the IEB alterations and intestinal inflammation associated with obesity. Three multivalent and gut-restricted carboxylate-based selective inhibitors of MMP-12 were synthesized and tested first on human recombinant MMP-12 isolated enzyme and then on human intestinal epithelial Caco-2 cells treated with palmitate (PA) and lipopolysaccharide (LPS), to mimic the in vivo exposure to hypercaloric diet. Trimeric derivative 2 in particular showed a nanomolar activity against MMP-12 and was able to increase both ZO-1 and claudin-1 tight junction expression in a concentration-dependent manner, already at a concentration of 50 nM. This compound was also the most effective in reducing interleukin-1β release from Caco-2 cells treated with PA and LPS. This preliminary work indicates that a pharmacological modulation of MMP-12 represents a promising strategy to counteract the impairment of IEB integrity and intestinal inflammation associated with obesity.
Potential habitat suitability analysis under climate change for the native grass, Kengyilia thoroldiana, on the Qinghai-Tibet Plateau
Authors: Zhang Hairong , He Miaohua , Shi Jianjun , Ma Yuan , Ou Weiyou , Xing Yunfei , Liu Qingqing , Xu Gongfang , Lv LiangYu , Cai Zongcheng
Published: September 2024

Kengyilia thoroldiana is a dominant species in the desertification area of the Qinghai-Tibet Plateau. In this study, based on 88 sample points of Kengyilia thoroldiana, the Maximum Entropy (MaxEnt) method was used to analyze the current dominant factors of the distribution area of Kengyilia thoroldiana and predict its potential distribution. The results show that the training and test data area under the curve (AUC) were 0.934 ± 0.004 and 0.944 ± 0.043, respectively, which indicated the reliability of the predicted results. Based on climatic variables and the results of the “Jackknife” method, The results showed that temperature is the main cause of Kengyilia thoroldiana distribution. By simulating the potential distribution of Kengyilia thoroldiana, the highly suitable areas were mainly located in the west, south, and southeast of Qinghai, southwest Gansu, and eastern Tibet. In future climate scenarios, the total suitable area for Kengyilia thoroldiana showed an expanding trend. According to the Sustainable Development (SSP126) scenario, the highly suitable areas could increase by 4.72% from 2021 to 2040 compared with the current climate scenario, and the highly suitable areas could increase by 12.71% from 2041 to 2060. An increase in the suitable areas of Kengyilia thoroldiana is essential for the ecological restoration of degraded grasslands.
Development of a skeletal muscle sheet with direct reprogramming-induced myoblasts on a nanogel-cross-linked porous freeze-dried gel scaffold in a mouse gastroschisis model
Authors: Nagano Shinta , Fumino Shigehisa , Kishida Tsunao , Wakao Junko , Hirohata Yoshiaki , Takayama Shohei , Kim Kiyokazu , Akiyoshi Kazunari , Mazda Osam , Tajiri Tatsuro , Ono Shigeru
Published: September 2024

Purpose: In this study, we attempted to create skeletal muscle sheets made of Directly converted myoblasts (dMBs) with a nanogel scaffold on a biosheet using a mouse gastroschisis model.
Methods: dMBs were prepared by the co-transfection of MYOD1 and MYCL into human fibroblasts. Silicon tubes were implanted under the skin of NOG/SCID mice, and biosheets were formed. The nanogel was a nanoscale hydrogel based on cholesterol-modified pullulan, and a NanoClip-FD gel was prepared by freeze-drying the nanogel. 7-mm in length were created in the abdominal wall of NOG/SCID mice as a mouse gastroschisis model. Matrigel or NanoCliP-FD gel seeded with dMBs was placed on the biosheet and implanted on the model mice.
Results: Fourteen days after surgery, dMBs with matrigel showed a small amount of coarse aggregations of muscle-like cells. In contrast, dMBs with NanoCliP-FD gel showed multinucleated muscle-like cells, which were expressed as Desmin and Myogenin by fluorescent immunostaining.
Conclusion:Nanogels have a porous structure and are useful as scaffolds for tissue regeneration by supplying oxygen and nutrients supply to the cells. Combining dMBs and nanogels on the biosheets resulted in the differentiation and engraftment of skeletal muscle, suggesting the possibility of developing skeletal muscle sheets derived from autologous cells and tissues.
Characteristics of eclampsia not preceded by hypertensive disorders of pregnancy: a case control study
Authors: Sato Maki , Iino Kaori , Ozaki Takashi , Hashimoto Tetsuji , Osawa Yuki , Hashimoto Rikako , Tando Tomoe , Takeda Aisa , Takahashi Sota , Taniguchi Ryosuke , Oishi Maika , Ito Asami , Tanaka Kanji , Yokoyama Yoshihito
Published: September 2024

Background Eclampsia, a severe complication of pregnancy characterized by seizures, has traditionally been associated with hypertensive disorders of pregnancy (HDP). However, a significant proportion of eclampsia cases occur without a prior diagnosis of HDP, suggesting the existence of alternative pathophysiological mechanisms. This study aimed to explore the characteristics of eclampsia not preceded by HDP and to offer insights into its underlying mechanisms and potential risk factors.Methods We conducted a retrospective analysis of eclampsia in 31 singleton pregnancies diagnosed at nine Japanese hospitals with perinatal and maternal centers between May 2007 and March 2023. Data on background factors, blood pressure measurements, laboratory test results, and imaging findings were collected and analyzed. Patients were classified into two groups: eclampsia preceded by HDP and eclampsia not preceded by HDP, and comparisons were made regarding background factors, perinatal outcomes, and test results were compared.Results Of the 30 cases of eclampsia, 17 (57%) were not preceded by HDP, while the remaining cases had been diagnosed with HDP prior to the onset of eclampsia. In the eclampsia not preceded by HDP group, compared to the eclampsia preceded by HDP group, the BMI was lower, the gestational week at delivery was earlier, and the proportion of male neonates was higher (P < 0.05). When comparing the onset periods among the three groups—antepartum, intrapartum, and postpartum—the eclampsia not preceded by HDP group exhibited the highest number of cases during the intrapartum period, with 9 cases (52.9%). Conversely, the eclampsia preceded by HDP group showed the highest number of cases during the postpartum period, with 8 cases (61.5%). Furthermore, in the Eclampsia not preceded by HDP group, the white blood cell count was significantly higher immediately after onset (P < 0.05).Conclusions Eclampsia not preceded by HDP may involve inflammatory and immune responses triggered by labor, unlike typical eclampsia, which is associated with a rapid increase in blood pressure. Recognizing atypical eclampsia as a separate entity may aid in developing more effective prediction, prevention, and treatment strategies for this life-threatening condition.
AKAP8 regulates R-loop balance and promotes growth of lung carcinoma cell
Authors: Wang Xu , Liu Liang
Published: September 2024

Background RNA:DNA hybrid structure known as R-loop, which forms during transcription plays a pivotal roles in transcriptional regulation. Dysregulation of R-loop dynamics disrupt normal DNA replication or RNA transcription, potentially leading to disturbances of cell metabolism, abnormal cell proliferation and disease progression.Methods Interactome data of nucleic AKAPs and R-loop were collected and analyzed to nominate the candidate of AKAP8 (A-kinase-anchoring protein 8) as R-loop binding protein. The interaction of AKAP8 and R-loop were confirmed by co-immunoprecipitation and immunofluorescence. R-loop resolution protein DDX5 were identified to interact with AKAP8 and its nucleic abundance was estimated. AKAP8 knock down cell lines were constructed. The mRNA profile and differential expressed genes of were analyzed. Downstream target gene UCP2 was confirmed upregulate by AKAP8 and R-loop level of UCP2 promoter was estimated. Cell growth and migration of lung carcinoma cell line with depletion of AKAP8 or not were also investigated by EdU, colony formation and wound healing essay. Expression score of AKAP8 comparing lung cancer tissue with normal tissue, and correlation between survival possibility of lung cancer patients and expression level of AKAP8, were also investigated.Results This study identified that AKAP8 interacted with R-loop structure within cells. Depletion of AKAP8 resulted in perturbation of genomic R-loop balance and gene transcription. Evidences was shown that AKAP8 interacted with R-loop resolution protein DDX5 and regulated chromatin associated DDX5 level. Furthermore, AKAP8 was found to enhance transcription uncoupling protein UCP2 as well as alleviate R-loop level of UCP2 promoter, and promoted cell growth and migration of lung carcinoma cell. The lower survival possibility was found in lung cancer patients with high level AKAP8 expression.Conclusions This study elucidates novel roles of AKAP8 in modulating R-loop balance by cooperation of DDX5 and AKAP8 is as one of the motivators for lung carcinoma cell growth contributed by mitochondrial metabolism. This insight may offer prognostic significance for patients with lung adenocarcinoma exhibiting higher AKAP8 expression.
Bi-directional causal association between 17 neurosurgical diseases and three emotional disorders: perspective from Mendelian randomization analysis
Authors: Chen Haonan , Zhang Renhao , Wen Xinjie , Shao Dongqi , Fu Qiang , Yin Shichao , lv Yifan , Sun Tao
Published: September 2024

Background
Although numerous studies have reported correlations between emotional disorders and neurosurgical conditions, their causal relationships is not convincing. Therefore, we seek to comprehensively investigate the connection between the two using bidirectional Mendelian randomization studies.
Methods The GWAS aggregated data encompassed 17 types of neurosurgical diseases (including cerebrovascular diseases, functional disorders, central nervous system neoplasms, spinal and spinal cord diseases, and other brain conditions) and 3 emotional disorders (anxiety, mania, and depression), sourced from IEU and FINNGEN. The primary analysis method applied was inverse variance-weighted (IVW) analysis, supplemented by MR-Egger and weighted median methods to ensure robust estimates. A series of sensitivity analyses, including Cochran’s Q test, MR-Egger regression, and leave-one-out analysis, were conducted to detect pleiotropy or heterogeneity.
Results IVW estimates indicated that trigeminal neuralgia significantly associated with the risk of mania (p=0.002, odds ratio [OR]=1.008, 95 % confidence interval [CI] = 1.003 to 1.014), a higher genetic predisposition to congenital malformations of nervous system may reduce the development of depression (p=0.002, OR= 0.996; 95 %CI = 0.992 to 0.998) and the causal effect of depression on transient ischemic attack (IVW, P=0.004, odds ratio (p=0.004, OR = 4.141; 95 %CI = 1.560 to 10.988). The results of comprehensive sensitivity analyses were consistent with the main causality estimate. No pleiotropy and heterogeneity were detected in our MR study.
Conclusions Our large-scaled MR analysis indicated that trigeminal neuralgia and congenital malformations of the nervous system predispose patients to emotional disorders, while depression, in particular, increases vulnerability to transient ischemic stroke.
Case Report: Thrombectomy for left internal carotid artery occlusion with ipsilateral dual accessory middle cerebral arteries
Authors: Tega Jota , Horio Yoshinobu , Suzuki Koichiro , Oka Yuta , Takemoto Koichiro , Abe Hiroshi
Published: September 2024

Accessory middle cerebral arteries (AMCAs) are found in 0.3-4.0% of cases, and ipsilateral dual AMCAs are rare. A seventy-three-year-old man presented with right hemiplegia and total aphasia. Magnetic resonance angiography showed left carotid artery occlusion. We infused him with tissue plasminogen activator. Digital subtraction angiogram showed revascularization of the left internal carotid artery. However, the left proximal anterior cerebral artery was occluded. We performed mechanical thrombectomy and achieved partial reperfusion. CT angiography on the tenth day showed ipsilateral dual AMCAs. Due to middle cerebral artery anomalies, we performed mechanical thrombectomy using contact aspiration which is safer than other techniques.
Healthcare Providers and the Lingering Influence of the COVID-19 Pandemic
Authors: Ness Michelle , DiFusco Leigh Ann
Published: September 2024

Purpose
To gain a better understanding of the experiences of healthcare providers caring for adult patients during the second year of the COVID-19 pandemic.
Methods
A descriptive, qualitative design was conducted using semi-structured interview questions. Eleven participants were recruited from a sample of 28 healthcare providers to participate in video interviews. Thematic analysis was used to analyze data.
Results
Healthcare providers experienced continued distress related to concerns about the long-term effects on themselves, their families, and society. Three themes emerged from the data: (1) exhausted and emotionally numb; (2) vaccinated versus the unvaccinated; and (3) stressors and misguided supports.
Conclusion
The lingering COVID-19 pandemic led to continued distress among healthcare providers. Themes highlight the challenges faced by healthcare providers as they continued to care for patients during the lingering pandemic. Leadership must continue to prioritize support for healthcare providers for the duration of healthcare disasters to promote quality of life, reduce burnout, and increase job satisfaction. Findings from this study can inform the development of much needed institutional support for front line healthcare providers during times of crisis.