bluuebunny/crossref_metadata_2025 huggingface dataset:
Teoria do queijo suíço para redução e controle de consumo em um Centro Integrado de Inclusão e Reabilitação: um relato de experiência
Authors: Pinheiro Leisson Domingues , Gomes Rejane Xavier Soares , Freitas Maria do Carmo da Silva , Maciel Fabrícia Dias , Goto Elizabeth Sachimi , Breves Jimmy Bryan de Castro , Pires Francyisis da Silva
Published: April 2024

Objetivo: Avaliar a eficácia da teoria do queijo suíço no Centro Integrado de Inclusão e Reabilitação (CIIR). Relato de experiência: Entre julho e agosto de 2023, foram realizadas reuniões com os setores de logística, custo, estatística e contabilidade do CIIR. Cada setor monitorou o consumo de acordo com metas orçamentárias predefinidas. Diariamente, a logística enviava uma planilha à gerência administrativa financeira, detalhando itens dispensados, meta orçamentária, projeção e porcentagem de consumo. As reuniões contínuas e o alinhamento de objetivos resultaram em melhor compreensão da equipe, resolutividade de problemas e indicadores positivos. Houve uma queda significativa nos custos de R$ 508.111,55 em julho para R$ 465.536,78 em agosto, e R$ 421.118,03 em setembro. Essa tendência de redução indica uma gestão financeira eficiente e a implementação de barreiras eficazes para cortar custos. Considerações finais: As quedas consistentes nos custos mensais refletem um esforço bem-sucedido na gestão e otimização dos recursos.
Desenvolvimento e prototipação de aplicativo para melhoria do acesso à informação em saúde pública
Authors: Faccin Deniz , Santana José Eduardo , Perez Gabriel Vazarin , Tereza Samuel Domiciano , Barros Vanessa Tavares de Oliveira , Barros Rodolfo Miranda de
Published: April 2024

Objetivo: Desenvolver e prototipar um aplicativo para melhorar o acesso à informação em saúde pública para cidadãos, profissionais da saúde e gestores, gerando valor público. Métodos: O estudo foi conduzido nas capitais Florianópolis e Maceió. A metodologia foi estruturada em cinco etapas: revisão da literatura; coleta de dados sobre as necessidades de informação dos stakeholders e preferências com relação à usabilidade; análise de feedbacks de usuários de soluções similares; especificação dos casos de uso; desenvolvimento do protótipo utilizando a metodologia de design atômico. Resultados: Os dados coletados reforçaram a hipótese de que o acesso à informação possui lacunas importantes e permitiram a identificação das necessidades mais relevantes. O protótipo mostrou ser intuitivo e personalizável para diferentes municípios, com potencial de beneficiar cidadãos, profissionais de saúde e gestores. Conclusão: O aplicativo proposto oferece uma solução promissora para os desafios relacionados à informação em saúde pública, potencializando uma rede de atenção à saúde mais eficiente e informada.
A Novel Approach for Evaluation of Hesperidin in Vincristrine-Induced Neuropathy in Rats
Authors: Patil Vinod R , Upasani Chandrashekar D
Published: April 2024

The present study set out to determine how hesperidin altered the neuropathic pain that vincristine-induced on rats. Rats were given vincristine to cause painful neuropathy. To measure the mechanical dynamic allodynia, cold allodynia, degree of mechanical hyperalgesia, heat hyperalgesia in addition to muscle relaxants rota rod, respectively, several pain-sensitive tests, including the von frey hair test pinprick, hot plate, and rota rod, were carried out on various weeks (00, 04 and 08 week ). As indicators of inflammation and oxidative stress, the IL-1β, IL-10, and tumor necrosis factor-α, tissue parameters like Na+/K+ ATPase, Ca2+ ATPase & Mg2+ ATPase, and SOD, CAT level, reduced glutathione (GSH), lipid peroxidase (LPO), NO level were assessed. Gabapentin (30 mg/kg i.p.) in addition to hesperidin (50, 100, as well as 150 mg/kg orally) were given for 08 weeks. Hesperidin administration significantly reduced vincristine-induced behavioral and biochemical alterations (p <0.05). Hesperidin also reduced the inflammation IL-10, and increased in IL-1ß, and TNF-ɑ. Hesperidin also reduces oxidative stress (LPO, NO level) and increases at (GSH, SOD, CAT levels) that vincristine caused. Hesperidin can alleviate the painful states brought on by vincristine-induced painful neuropathy, which might also be explained by its anti-inflammatory effects and following reduction of oxidative stress..
Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug
Authors: Janugade Bhagyesh U , Singla Neelam
Published: April 2024

The current research aimed to prepare and estimate bioadhesive pulsatile drug delivery system (BPDDS) of an antihypertensive drug, losartan potassium, containing the formulation of a fast-dissolving core tablet and a combination of core tablet to polymer coating to formulate (BPDDS) tablet through a direct compression procedure. The coating was completed by utilizing polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was entirely assessed for the formulations. Altogether, estimation tests were found to be inside parameters. The expected lag time for hypertension is 8 hours; hence this lag time was achieved by using a bioadhesive pulsatile system. The optimized formulation showed 8 hours lag time with appropriate mucoadhesion for an equivalent period. Therefore, the BPDDS was greatest preventative substitute for drug which are the highest absorption in the stomach and for drugs which used to treat diseases with a circadian rhythm.
Polyherbal Formulation for Atherosclerosis: GC-MS Fingerprinting, In-vivo Antioxidant and Antibacterial Activities
Authors: Rayadurgam Sireesha , Krishnan Manikandan
Published: April 2024

Atherosclerosis is a prolonged inflammatory disease affecting large and medium-sized arteries, requiring a phytotherapeutic approach that incorporates multiple bioactive elements and a multi-target strategy. A novel polyherbal formulation has been formulated to treat atherosclerosis. The methanolic extract of the formulation has been characterized using gas chromatography–mass spectrometry (GC-MS) fingerprinting analysis. The extract was further screened for antioxidant activity like DPPH radical scavenging assay, hydrogen peroxide scavenging activity, intracellular reactive oxygen species (ROS) activity and antibacterial activity like Resauzarin assay as most of the identified compounds are with antioxidant and antimicrobial properties. Upto 38 phytocompounds were tentatively identified by GC-MS characterization using NIST library. Scavenging activities were observed more in the DPPH assay, ranging from 33.33 to 86.68% than in the hydrogen peroxide scavenging assay which ranged from 31.05 to 81.66%. In the resauzarin assay, the plant extract displays substantial antibacterial activity compared to the positive control chloramphenicol. The DPPH and hydrogen peroxide scavenging activity results indicate that the extract has significant radical-scavenging properties compared to the positive control ascorbic acid. Based on MIC values in antibacterial assay, the extract exhibits potential antibacterial activity, stating its stability towards bacterial growth.
Molnupiravir Bioanalytical Method Development and Validation in Rat Plasma by LC-MS/MS Detection and Application to a Pharmacokinetic
Authors: Reddy Konatham TK , Haque MA
Published: April 2024

This work aims to propose a novel method for detecting the concentration of molnupiravir in rat plasma that has been developed and verified. This approach makes use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology. Furthermore, the method’s pharmacokinetic applicability in rats was assessed. Phenyl, 250 x 4.6 mm, 5 μm analytical column, operating at room temperature, was utilized to accomplish separation. The investigation employed a mobile phase consisting of a 40:60 v/v combination of 0.1% tri fluoro acetic acid and methanol at a 1.0 mL/min flow rate and an injection volume of 10 μL. The liquid chromatography (LC) procedure was carried out for four minutes. In +ESI mode, the mass spectrometer was in operation. The determination of the mass-to-charge ratio transitions for molnupiravir and D7-Molnupiravir (m/z 330.34→82.46 and 337.46→286.11, respectively) was accomplished through the utilization of multiple reaction monitoring (MRM. The concentration ranges for molnupiravir were determined to be 6.25 to 50.00 ng/mL, with a correlation coefficient 0.9996. The precision and accuracy of HQC, MQC, LQC, and LLQC were found to be 98.34, 98.83, 98.13, and 97.85%, respectively. In pharmacokinetic studies, it was observed that molnupiravir exhibited an average AUC0-t value of 65 ng-hr/mL and a Cmax value of 43.120 ng/mL in rats. In conclusion, the validated created approach has effectively demonstrated the determination of pharmacokinetic parameters subsequent to the oral administration of molnupiravir in wistar rats.
Forced Degradation Method Development and Validation for Simultaneous Determination of Vildagliptin, Metformin Hydrochloride and Remogliflozin Etabonate in Bulk and its Formulation by RP-HPLC
Authors: CS Kagarana , KN Patel , AB Patel
Published: April 2024

A simple and efficient stability-indicating method has been developed and validated for the simultaneous estimation of vildagliptin, metformin hydrochloride and remogliflozin etabonate in bulk and was applied on marketed formulations. KH2PO4 buffer (10 mM): Acetonitrile (70:30% v/v) at pH 5 was used as a mobile phase. Detection of drug peaks was at 215 nm by UV detector. The method was found to be linear in the concentration range of 2.5 to 7.5, 25 to 75 and 5 to 15 μg/mL for vildagliptin, metformin hydrochloride and remogliflozin etabonate, respectively. The limit of detection (LoD) and quantitation (LoQ) were found to be 0.137 and 0.415 μg/mL for vildagliptin, 3.737 and 11.326 μg/mL for metformin hydrochloride and 0.348 and 1.055 μg/mL for remogliflozin etabonate. Hydrolysis by HCl, NaOH, hydrogen peroxide, UV light and temperature were performed on a formulation which proves that the proposed method was specific
Dose-Dependent Effect of Cardioprotective Properties of Azilsartan in Experimental Model of Myocardial Infracted Diabetic Rats
Authors: Shirsath Shailaja S , Otari Kishor V , Goyal Sameer Narayan
Published: April 2024

This investigation aimed to investigate whether azilsartan, a drug that acts as both an angiotensin II receptor antagonist and a limited PPAR-γ inhibitor, can prevent AMI in rats that were administered isoproterenol. The study aimed to determine if azilsartan treatment could reverse the hemodynamic, biochemical, and histopathological variations observed in the rat myocardium. The damaging effects of isoproterenol on the heart were evident from the significant reduction in SAP, DAP, and MAP, in addition to in indicators of MI contraction as well as relaxation ( ± LVdP/dtmax) together through a surge in LVEDP, an indicator of pre-load. Additionally, the actions of important enzymes like CK-MB, LDH, along with antioxidant enzymes for example, superoxide dismutase (SOD) and catalase, in adding to the stage of glutathione (GSH), were notably reduced. An elevation in malondialdehyde (MDA) content, a marker of oxidative stress, accompanied this. In this study, rats were pre-treated with different doses of azilsartan (1, 5, and 10 mg/kg bw) orally for 14 days before being induced through isoproterenol-induced myocardial injury. The outcomes of the examination presented that azilsartan had a protecting outcome on the myocardium in this experimentally induced model of myocardial infarction (MI). The treatment with azilsartan improved various parameters, positively impacting the damaging effects caused by isoproterenol (ISO).
Development of HPLC Approach for Anticancer Drugs Combination Assay: Determination of Stability Indicating Quality and Stabilities of Anticancer Drugs Studied under the ICH Outlined Degrading Conditions
Authors: Kumar Kolapaneni A , Aravind S , Annam Sri C , Rao Mannam S
Published: April 2024

The combined use of tegafur (TAR), gimeracil (GAR), and oteracil (OAR) is often employed for the therapy of malignant tumors. A high-performance liquid chromatography (HPLC) approach was developed to consistently and precisely measure GAR, OAR, and TAR in a combined pharmaceutical formula that uses a shorter operation time. The separation followed by assessment of GAR, OAR and TAR is done with C18 (Waters, USA) column (250; 4.6 mm; temperature 25˚C) and the mobile phase ratio used included 60% vol (0.1 M NaHSO4): 40% vol (methanol). Upon applying stress conditions, International Council for Harmonisation (ICH) recommended to GAR, OAR and TAR. The HPLC findings pointed out the nonexistence of any interference between the drugs under test and the degradation compounds. The stability indicating quality was established by the peak purity results for GAR, OAR, and TAR, which disclose that the test peaks (GAR, OAR, and TAR) were homogenous in all stress settings examined. From stability studies, we found that GAR showed significant degradation when rendered to dry heat, while TAR and OAR exhibited significant degradation after being exposed to acidic conditions. The suggested approach could potentially be implemented to assess the stability of GAR, OAR, and TAR under stress environments as well as to perform quality control checks on the three mentioned drugs in capsule doses.
Chronic Toxicity Investigations with Nilavembu Kudineer in Sprague-Dawley Rats
Authors: Sukkur Asali AA , Samuel Anbu JSJ , S Sangeetha , Vimala Anita GKA
Published: April 2024

The safety assessment of Nilavembu Kudineer (NVK), a polyherbal formulation with a wide spectrum of medicinal applications, was meticulously conducted in Sprague-Dawley rats. Over the course of 90 days, NVK was orally delivered at dosages of 100, 200, and 400 mg/kg to test for chronic toxicity. The results of this research provide important information on the relative safety of NVK and its possible effects on human health. Neither death nor any treatment-related adverse clinical manifestations were recorded during the chronic investigation. Feed intake and body weight increase were similar across animals given NVK, with the exception of a little decrease in females in the 200 and 400 mg/kg groups. No adverse findings were found in the ocular investigations performed as part of the safety study. Comprehensive analyses of urinalysis, hematological parameters, and biochemical markers subsequent to NVK administration identified minor alterations in select parameters at distinct dose levels, without any overarching systemic effects. Importantly, both gross and histopathological examinations revealed an absence of lesions directly attributable to NVK treatment. The findings contribute substantial insights to the realm of herbal medicine, providing a solid foundation for the responsible integration of NVK into diverse healthcare contexts.
Cyperus articulatus L.: A Review on Phytochemical & Pharmacological Exploration, and Effects on Human Health
Authors: Dhar Susmita , Datta Samaresh , Yadav Akash
Published: April 2024

Cyperus articulatus L., a member of the Cyperaceae family, is distinguished by delicate blooms at its tips. Traditionally used in northern Brazilian spas and artisanal colonies, the tubers sliced from the plant’s stalks emit a refreshing, woodsy, and spicy aroma. Beyond its aesthetic and aromatic appeal, the plant boasts significant medicinal and pharmacological benefits. Pharmacologically, it exhibits properties such as antimalarial, sedative, hepatoprotective, central nervous system (CNS) contraceptive, insecticidal, antibiotic, anticancer, antioxidant, anticonvulsant, and anthococcosis medication. For instance, the chloroform extract of priprioca rhizomes revealed antimalarial metabolites, including “cyperotundone, alpha-cyperone, and mustacone.” The “C. articulatus rhizome decoction” contained sedative sugars, flavonoids, saponins, triterpenes, and polyuronides. Notably, the study did not detect metabolites related to hepatoprotection, contraception, and the central nervous system. Insecticidal activities were linked to the aromatic compounds, mono and sesquiterpenes, of the rhizome methanolic extract. Antibacterial activity, attributed to compounds and pinene, was found in ethanolic and chloroform extracts of rhizomes. The essential oil from C. articulatus exhibited anticancer effects, featuring sesquiterpenes and monoterpenes. Phenolic chemicals in the essential oil were associated with antioxidant capabilities. Alkaloid chemicals in C. articulatus rhizome extract demonstrated anticonvulsant action, along with the presence of linoleic acid and mustakone metabolites. This study comprehensively explores the medicinal, therapeutic, and pharmacological benefits of C. articulatus.
Prosecutoral supervision in anti-corruption field
Authors: Yakovlev N. M. , Ivanov S. M.
Published: April 2024

The role and importance of prosecutorial supervision in the anti-corruption sphere is constantly increasing, updating, strengthening, and the powers of the prosecutors themselves are also growing. In turn, issues of eliminating or neutralizing the grounds that form these problems must be resolved in a comprehensive manner, on a regular basis, in the case of combining activities on the part of legislative, law enforcement, law enforcement agencies and with the institutions of modern civil society. In this article we will consider the features of prosecutorial supervision in the anti-corruption field.
Criminal law protection of personal data in the context of digitalization
Authors: Govorova D. P.
Published: April 2024

In the context of digital transformation and the concept of the widespread introduction of digital technologies, artificial intelligence in various spheres of life and production, the state should provide effective guarantees for the protection and safety of information. In such circumstances, the issue of criminalizing the illegal use and (or) transfer, collection and (or) storage of personal data, including biometric data, becomes especially relevant. The article evaluates the possibility of considering personal data as an independent object of criminal law protection, and also attempts to analyze the degree of protection from criminal encroachments from the point of view of current legislation.
On the issue of audio recording of court proceedings
Authors: Ivanova E. S.
Published: April 2024

The article discusses aspects of conducting audio recording of court sessions and familiarizing the participants with the audio protocol. It explores technical aspects of equipment for audio recording, as well as the issues related to acquainting individuals held in custody. Familiarizing participants with the audio protocol of court sessions is not only a duty of the courts but also the realization of the right to transparency and legality of court proceedings, as well as the right to defense. The article provides an example from the review of appellate court practices in criminal cases, leading to the annulment of the firstinstance court verdict.
A mythoepic basis of the Adyghe New Year
Authors:   T. M. Kerashev Adyghe Republican Institute for Humanitarian Research, Asfar КUЕК , Maryet KUEK ,   T. M. Kerashev Adyghe Republican Institute for Humanitarian Research
Published: April 2024

The article considers the traditional spring holiday “Alternation of heads of years” (Ilesyshye zablek1ygu) on March 21–23 among the Adygs (Circassians) people, dedicated to Shyuzeresh the patron saint of abundance and horsemen. The aim of the work is to study the mythoepic basis of the traditional holidays associated with the spring and winter solstices. Based on this goal, the tasks of identifying representations of sacred processes designed to create favorable conditions for the preparation and start of spring field work and seasonal agricultural completion of the year are solved. The relevance of the research topic is due to the insufficient knowledge of the calendar holidays of the Adygs, in this case, associated with the vernal equinox and winter solstice. The theoretical basis of the mythological rituals requires in-depth study, since the process of reanimation of folk festivals is one of the important components of the self-identification of the Adyghe. Travel essays by missionaries, the research activities of the Adyghe enlighteners of the 19th century Sultan Khan Giray, Shora Nogmov, Adil Giray Keshev, folklorists Askarbiy Shortanov, Mukhtar Meretukov, Adam Gutov, Aslan Tsipinov and other scholars served as the methodological basis of this work and determined the basic principles of research: the comparative-historical, historical-typological, and comparative analyses. The novelty of the study lies in the fact that it describes for the first time the rituals of the spring festival, symbolizing the onset of the Adyghe New Year, and the time of spring plowing, which began on the third day after the onset of the holiday “Alternating heads of Years”, as well as the winter solstice holiday. The result of the study was the conclusion that the worldview and worldview of the ancient Adyghe was at a high level for its time and evolved along with the process of progressive development of the Adyghe society. It is established that a historical and cultural excursion into the past about the existence of the New Year among the Adyghe (Circassians) and the winter solstice holiday makes it possible to know the depth of the processes of the mythoepic consciousness of the people. The theoretical and practical value of the work is seen in the possibility of using the results of the research in theoretical disciplines and practical research on folklore, epic studies, the study of the mythoepical basis of the Adyghe worldview, as well as in the educational process of educational institutions.
Paysage et catégories topologiques
Authors: Beyaert-Geslin Anne
Published: April 2024

Pourquoi reconnaissons-nous un paysage là où un tableau montre deux bandes superposées ? Comment, plus généralement, stabilisons-nous l’icône du paysage ? Si de telles questions se posent devant les peintures de la série de Thierry de Cordier, intitulée Un homme, une maison et un paysage, qui les situe dès l’abord dans le genre du paysage, elles se posent aussi devant les œuvres de Mark Rothko qui, ne se trouvant pas inscrites dans le genre, utilisent pourtant certains principes fondateurs du paysage tels l’horizontalité, la superposition de bande et en certains cas, le format du paysage.On interrogera donc ce primat topologique du paysage qui convoque les catégories topologiques de Greimas, de même que les notions de support et de format qui révèlent ici leur importance pour la stabilisation iconique.Voyant comment une icône du paysage se stabilise (ou ne se stabilise pas), on fera le lien entre le genre du paysage et les pratiques énonciatives, une pratique de peintre-écrivain pour de Cordier qui recourt au support de la page et associe peinture et écriture contre une pratique de peintre pour Rothko.
Perspective and the geometric control of the pictorial act
Authors: Fiers William
Published: April 2024

La peinture est l’œuvre d’une instance de l’énonciation, le peintre, qui inscrit son geste sur une surface d’inscription, la toile. Elle est le résultat d’une mise en forme, d’un faire artistique, relevant d’une compétence technique gestuelle, mais également d’un savoir- comment-faire, relevant d’une compétence cognitive. Quand la mise en peinture technique d’un simple cercle est le résultat d’un faire maîtrisé  une figure décrite par toute ligne dont une extrémité est fixe, et l’autre, mobile (définition générique)  son savoir-comment-faire suppose une connaissance – le cercle comme lieu des points situés à égale distance d’un point nommé centre (définition spécifique) – qui guide et structure le geste technique. Si l’on applique ces considérations à la construction de la perspective, on sera amené à considérer celle-ci comme la mise en application d’une compétence cognitive spécifique. A travers un tableau d’Auguste Aridas (1848-1929, peintre et professeur de dessin à Limoges pendant de longues années), représentant un véritable cours sur la mise en perspective, tant au niveau énonciatif qu’au niveau énoncif, nous essaierons de mettre au clair le fonctionnement sémiotique de la perspective comme « dispositif d’énonciation paradigmatique » (Damisch).
Création et restructuration identitaire. Pour une sémiotique de la créativité
Authors: Basso Fossali Pierluigi
Published: April 2024

La création articule la dialectique entre perception et imagination, langue et textes, praxis et invention. Donc, elle relève d’une écologie sémiotique qui concerne le temps (la création convoque la mémoire à fin d’oublier des connexions sédimentées) et l’espace (elle reformule la relation tensive entre domaine opérable de valeurs autonomes et domaine opératif de valeurs hétéronomes). La création est une « héroicisation » de l’initiative  étant donné qu’elle symbolise le sujet comme capable de singularisation au dedans d’un paysage de valeurs préconstitués, sans qu’il doive renoncer à un principe d’organisation. Au contraire, la création va instaurer un ordre naissant capable de fertiliser tout un champ de production sémiotique. La création traduit l’espace d’effectuation de l’agir dans un scénario figurale où on assiste à la de-dramatisation cathartique de la dramaturgie expérientielle garantie par les émotions. Le caractère exaltant de la création est la transposition des patterns émotionnels de la souveraineté du destin à la juridiction du possible.
Kitsch et dérision
Authors: Bertrand Denis
Published: April 2024

En assumant une des propriétés de la dénomination « kitsch », qui est d’intégrer dans la désignation même une modalité de jugement, on s’attache à dégager la composition sémiotique et énonciative de ce jugement, ainsi que ses implications quant à la « réalité » fluctuante de l’objet qu’il désigne ainsi. Ce jugement relève du discours de la dérision dont on cherchera à mettre en évidence le composé d’humour et d’ironie qu’il manifeste. La distinction entre ces deux formes de dérision repose sur les deux régimes de déformation d’une règle qui les caractérisent : déformation d’un ordre syntagmatique dans le cas de l’humour, générant des valeurs extrémales d’hyper-qualification, déformation d’un ordre paradigmatique dans celui de l’ironie, générant des valeurs de disqualification. Quel en est le régime dans le cas du jugement de kitsch ? Et surtout comment se positionnent les instances appelées à participer à la scène kitsch du sens ? La ronde énonciative des instances en jeu dans cette scénographie, victimes consentantes de la praxis et de l’esthésis discursives, est envisagée notamment à partir d’un texte kitsch par excellence, Le Dictionnaire des idées reçues de Flaubert.
La sémiotique est-elle un art ? Le faire sémiotique comme « art libéral »
Authors: Fontanille Jacques
Published: April 2024

En référence à la classification médiévale des activités et domaines culturels, la sémiotique, saisie principalement comme un « faire », serait un des « arts libéraux » contemporains, c’est-à-dire, selon l’acception courante, « ceux dans lesquels le travail intellectuel est dominant », ce en quoi ils s’opposent par exemple aux « arts mécaniques » ou aux « beaux-arts », qui mettent en œuvre d’autres facultés dominantes. Dans cette perspective, bien entendu, la sémiotique perd son caractère de « projet scientifique », au sens où l’entendait Greimas, c’est-à-dire de connaissance généralisable, projective, construite par voie hypothético-déductive, reposant sur une théorie, des modèles et des méthodes empiriques. Mais elle ne le perd pas plus, pour autant, que la médecine, quand cette dernière passe de la recherche dite « in vitro » à la recherche dite « clinique » ; tout comme pour la médecine, en effet, il s’agit du passage d’une science fondamentale à une « pratique scientifique ». La sémiotique considérée comme un art est donc une pratique, où l’intelligence, la sensibilité, l’émotion et le goût ont également part. Et, tout comme la médecine encore, c’est une pratique dont le « texte » est un discours scientifique. C’est donc sur le fond de cette problématique générale qu’après avoir circonscrit le faire sémiotique comme « art » et comme « pratique », je voudrais ébaucher la description de quelques pratiques sémiotiques typiques : celles, notamment, de Jean-Marie Floch, d’Eric Landowski, d’Algirdas Julien Greimas ou de Claude Zilberberg.
Mémoire et médiation paysagère
Authors: Parouty-David Françoise
Published: April 2024

Notre objectif est de souligner la fonction médiatrice du paysage. Nous nous appuyons sur le paysage urbain comme surface d’inscription qui fait foi des événements historiques et des idées qui y sont corrélées, vérifiables dans quelques occurrences devenues emblématiques d’un sens et d’une valeur. Nous proposons une définition simplifiée du paysage qui permette de souligner le lien qui l’unit à la mémoire, structurante pour le sujet, dans ses deux dimensions temporelle et spatiale. Nous explorons ensuite les principales modalités d’inscription de la mémoire dans le paysage qui relèvent d’opérations énonciatives distinctes, avant de terminer par une recension des fonctions qu’induisent les pratiques, convaincue que nous sommes que le sens n’est jamais donné directement mais toujours médiatisé par une pratique qui le fait exister sous des formes parfois motivées par des logiques sociales.
KEMAMPUAN KOMUNIKASI MATEMATIS DITINJAU DARI KECERDASAN LOGIS MATEMATIS KELAS VIII
Authors: Umiati Umiati , Hamdani Hamdani , BS Dian Ahmad
Published: April 2024

This research aims to determine mathematical communication skills of students in terms of mathematical logical intelligence. The research method used is descriptive quantitative. The subjects of this study were 29 students of class VIII SMP Negeri 3 Pontianak. Data collection techniques used are direct measurement techniques and communication. Data collection tools used are test questions and interview guidelines. The results of the research generally show that mathematical logical intelligence is obtained by 74% in the high category, while the mathematical communication ability is obtained by 54% in the low category. Students who have high mathematical logical intelligence tend to have high mathematical communication skills, while students with low mathematical logical intelligence tend to have low mathematical communication skills
KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA DIKAJI DARI SELF CONCEPT SISWA DI KELAS VII
Authors: Sari Yunita , Halini Halini , Ijuddin Romal
Published: April 2024

This study is a descriptive study that discusses problem solving mathematics that has high, medium, and low self-concepts on algebraic material at MTs Darul Hidayah. The subjects in this study were seventh grade students of MTs Darul Hidayah who were in high, medium, and low self-concept classes. Data collection techniques are test techniques and direct communication techniques. Data collection tools used were questionnaires, problem questions, and interviews. Obtained from Students with high self-concept able to understand problems, able to plan problem solving, able to solve problems according to plan, and able to prove answers by re-examining the results that have been obtained; Students with moderate self-concept are able to understand problems, are able to plan problem solving, and are able to solve problems according to plan; Students with low self-concept are able to understand problems, able to plan problem solving, able to solve problems according to plan but with inappropriate final results.
Obesity May Impairs Mice Testicular Structure by STAT3/CYP19A1/Testosterone
Authors:   Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiao tong University, China, LU Mengnan , Feng Ruoyang ,   Department of Joint Surgery, HongHui Hospital, Xi’an Jiao tong University, China, Xiao Yanfeng ,   Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiao tong University, China, Yin Chunyan ,   Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiao tong University, China
Published: April 2024

Obesity is an increasing serious global public health issue and a risk factor for male infertility. Aromatase expression level is elevated in obese men, and this high level is as-sociated with diminished serum testosterone levels. We explored the underlying mechanism of infertility in obese men. Genome-wide association study datasets were used to predict the causal relationship between obesity and male infertility. An obese male mouse model was generated by feeding mice a high-fat diet while control model was generated by feeding mice a normal chow diet. Serum indicators including free fatty acids, insulin, Follicle-stimulating hormone, and testosterone were measured using ELISA, and impaired fertility in mice was demonstrated using immunohistochemistry. The expression levels of STAT3 and CYP19A1 were measured by RT-qPCR and western blotting, respectively. Simultaneous bioinformatics analysis of publicly available data was performed using the R programming language and JASPAR database. Obesity might lead to male infertility from a genomic perspective. Obese mice displayed reduced serum testosterone and follicle stimulating hormone levels along with structural abnormalities, ectopic lipid deposition, and chronic inflammation in the testes. Upregulation of STAT3/CYP19A1 expression in obese mice was linked to reduced serum testosterone levels and impaired fertility. Our observation may support the hypothesis that since the elevation of STAT3 expression in obesity, the promoted expressed CYP19A1 could increase a shift from testosterone to estrogens. The persistently elevated level of estrogen will further stimulate STAT3, which may constitute a positive feedback loop. These findings provide new insights into the mechanisms of obesity-mediated male fertility impairment.
Engineering Dehalogenase Enzymes using Variational Autoencoder-Generated Latent Spaces and Microfluidics
Authors: Kohout Pavel , Vasina Michal , Majerova Marika , Novakova Veronika , Damborsky Jiri , Bednar David , Marek Martin , Prokop Zbynek , Mazurenko Stanislav
Published: April 2024

Enzymes play a crucial role in sustainable industrial applications, with their optimization posing a formidable challenge due to the intricate interplay among residues. Computational methodologies predominantly rely on evolutionary insights, leveraging homologous sequences to pinpoint conserved and functionally critical regions. However, despite their notable advancements, deciphering the evolutionary variability and complex dependencies among residues presents substantial hurdles. Here, we present a new machine-learning method based on variational autoencoders in combination with a simple evolutionary sampling strategy to address those limitations. We customized our method to generate novel sequences of haloalkane dehalogenases, enzymes widely used in biodegradation, biocatalysis, and biosensing. Three consecutive design-build-test cycles improved the solubility of variants from 11% to 75%. Thorough experimental validation using the state-of-the-art microfluidic device MicroPEX resulted in 20 multiple-point variants. Nine of them, sharing as little as 67% sequence similarity with the template, showed a melting temperature increase of up to 9°C and an average improvement of 3°C. The most stable variant demonstrated a 3.5-fold increase in activity compared to the template, while five variants exhibited average dehalogenase activities. High-quality experimental data collected with 20 variants represent a valuable dataset for the critical validation of novel protein design approaches and scoring functions. Python scripts and data sets are available on GitHub (https://github.com/loschmidt/vae-dehalogenases), and interactive calculations will be possible via an easy-to-use website: https://loschmidt.chemi.muni.cz/fireprotasr/.
AlphaFold meets de novo drug design: leveraging structural protein information in multi-target molecular generative models
Authors: Bernatavicius Andrius , Šícho Martin , Janssen Antonius , Hassen Alan Kai , Preuss Mike , van Westen Gerard
Published: April 2024

Advances in deep learning have expanded the applications of virtual screening for drug-like compounds. More recently generative models have emerged as sources of inspiration for chemists. We introduce a multi-target model, PCMol, that leverages the latent embeddings derived from AlphaFold as a means of conditioning the de novo generative model on target proteins. It is known that the addition of protein descriptors is an effective strategy to extend the applicability domain and prediction capability of quantitative structure-activity relation (QSAR) models, a strategy we refer to as proteochemometrics (PCM). Similarly, the use of AlphaFold latent embeddings within a generative model for small molecules allows it to leverage structural relationships between proteins. This opens up new possibilities such as interpolation within the chemical space of known highly active compounds and extrapolation on the target side based on their similarities to other proteins, which is especially relevant for understudied or novel targets. Our results indicate that PCMol can generate diverse, potentially active molecules for a wide array of proteins, including those with sparse ligand bioactivity data. We also benchmark against existing target-conditioned trans-former models to illustrate the validity of using AlphaFold protein representations to steer the molecular generation process and increase the generalization capabilities to unseen targets. Additionally, we demonstrate the important role of data augmentation in bolstering the performance of generative models in low-data regimes. The open-source package along with a dataset of AlphaFold protein embeddings is available at https://github.com/CDDLeiden/PCMol.
Robust and High-Performance Textile-based Triboelectric Nanogenerators Integrated with 2D Materials for Sustainable Self-Powered Wearable Electronics
Authors: Ali Iftikhar , Karim Nazmul , Afroj Shaila
Published: April 2024

The human body continuously generates ambient mechanical energy through diverse movements, such as walking and cycling, which can be harvested via various renewable energy harvesting mechanisms. Triboelectric Nanogenerator (TENG) stands out as one of the most promising emerging renewable energy harvesting technologies for wearable applications due to its ability to harness various forms of mechanical energies, including vibrations, pressure, and rotations, and convert them into direct current (DC) electricity. However, their application is limited due to challenges in achieving performance, flexibility, low power consumption, and durability. Here, we present a robust and high-performance self-powered system integrated into cotton fabric by incorporating a textile-based triboelectric nanogenerator (T-TENG) based on 2D materials, addressing both energy harvesting and storage. The proposed system extracts significant ambient mechanical energy from human body movements and stores it in a textile supercapacitor (T-Supercap). The integration of 2D materials (graphene and MoS2) in fabrication enhances the performance of T-TENG significantly, as demonstrated by a record-high open-circuit voltage of 1068V and a power density of 14.64 W/m2 under a force of 22N. The developed T-TENG in this study effectively powers 200+ LEDs and a miniature watch while also charging the T-Supercap with 4-5N force for efficient miniature electronics operation. Integrated as a step counter within a sock, the T-TENG serves as a self-powered step counter sensor. This work establishes a promising platform for wearable electronic textiles, contributing significantly to the advancement of sustainable and autonomous self-powered wearable technologies.
Combined LC-MS/MS feature grouping, statistical prioritization, and interactive networking in msFeaST
Authors: Mildau Kevin , Büschl Christoph , Zanghellini Jürgen , van der Hooft Justin J.J.
Published: April 2024

Computational metabolomics workflows have revolutionized the untargeted metabolomics field. However, the organization and prioritization of metabolite features remains a laborious process. Organizing metabolomics data is often done through mass fragmentation-based spectral similarity grouping, resulting in feature sets that also represent an intuitive and scientifically meaningful first stage of analysis in untargeted metabolomics. Exploiting such feature sets, feature-set testing has emerged as an approach that is widely used in genomics and targeted metabolomics pathway enrichment analyses. It allows for formally combining groupings with statistical testing into more meaningful pathway enrichment conclusions. Here, we present msFeaST (mass spectral Feature Set Testing), a feature-set testing and visualization workflow for LC-MS/MS untargeted metabolomics data. Feature-set testing involves statistically assessing differential abundance patterns for groups of features across experimental conditions. We developed msFeaST to make use of spectral similarity-based feature groupings generated using k-medoids clustering, where the resulting clusters serve as a proxy for grouping structurally similar features with potential biosynthesis pathway relationships. Spectral clustering done in this way allows for statistical testing on the scale feature-sets using the globaltest package, which provides high power to detect small concordant effects via joint modeling and reduced multiplicity adjustment penalties. Hence, msFeaST provides interactive integration of the semi-quantitative experimental information with mass-spectral structural similarity information, enhancing the prioritization of features and feature sets during exploratory data analysis. The msFeaST workflow is available through https://github.com/kevinmildau/msFeaST and built to work on MacOS and Linux systems.
Conjugation Amplifies Complexity: A Comparison of Problem-Solving Strategies Across the Organic Chemistry Sequence
Authors: Cox Jr. Charles T. , Shimomura Reika , Hall Jaques T.V.E. , Gao Sean
Published: April 2024

Resonance structures are central representations in organic chemistry that explain trends in acidity, reactivity, geometry, and stability. Despite being a central representation, prior research findings have shown that students’ productive application of resonance as a resource is context-dependent. This research reports findings from a cross-sectional analysis study investigating how Organic Chemistry I (OC1) and Organic Chemistry II (OC2) students use resonance structures to describe acid-base properties, chemical shifts, and geometry. Six students from OC1 and six from OC2 participated in semi-structured interviews to capture their problem-solving pathways. Each prompt was designed to be answered using resonance structures. OC1 students, who noted resonance, were less successful with drawing and applying resonance structures than OC2 students, as expected. However, both cohorts used resonance structures to a limited extent – despite the similarities of molecules presented within each prompt. Resources that do not require structural manipulation, such as s-character and electronegativity, were commonly activated instead of resonance across both courses.
QUALITY OF ONLINE BANKING SERVICES IN SCHEDULED COMMERCIAL BANKS – A STUDY IN CHIKAMAGALURU DISTRICT
Authors: Kumar H.B. Dr. Rajith
Published: April 2024

The Online banking services plays significant role in carrying out ever increasing financial transactions of the country. The needs and wants of people have been raising with the creation of new policies by government. The financial inclusion has given a chance to connect all the stakeholders of the country in one large financial network which enables to provide uniform and reliable services with equity. All these policies have made the banks to adopt to technology for large scale delivery of services. The adoption of technology has to be scrutinized for knowing the effectiveness delivery of the services. The current research paper operates with the objectives of examining the satisfaction level of bank customers towards digital banking services and assesses effectiveness of service delivery mechanism of banks in the study area. The methodology of the study explains its empirical in nature based on the observational replies from the bank customers. The study has been conducted based on primary data using structured interview schedule with 230 samples. The study has adopted non-probability sampling of judgement sampling for selection of customers. The study based on analysis found that the satisfaction levels of bank customers are on the factors of Customer friendliness, Innovative Services and Time Saving Practices. There is exclusive model developed using the structural equation modeling to assess effectiveness of service delivery mechanism in commercial banks. The study concluded on the note that adoption towards the model will make the banks reduce the errors and improvise delivery of digital banking services.
FACING SECURITY CHALLENGES IN DIGITAL MARKETING AND HOW TO OVERCOME THEM
Authors: da Hil , Permata Gusti Girang
Published: April 2024

Digital marketing has become a critical component of modern business strategy, but it has also raised new challenges regarding cybersecurity. This research aims to investigate security challenges in digital marketing and the efforts made to overcome them. The research method used is a quantitative descriptive approach with secondary data collection. Data collected includes industry reports, articles, and previous studies related to cybersecurity in digital marketing. This data is analyzed to identify patterns and trends related to security threats and the strategies used by companies to deal with them. The research results show that digital marketing is faced with various security risks, such as data leaks, cyber-attacks, and fraud. Efforts to overcome these challenges include the use of advanced security technology, employee training on security awareness, and collaboration with third parties who are experts in the field of cybersecurity. This research provides an in-depth understanding of security in digital marketing and provides recommendations for companies to improve their security systems.
THE INFLUENCE OF CONTEXTUAL FACTORS OF MANAGEMENT ACCOUNTING PRACTICES: EVIDENCE FROM SME’S IN THE PHILIPPINES
Authors: M. Reyroso Joseph Alfred , C. Ibarra Venus
Published: April 2024

The study determined the management accounting practices of Small and Medium Enterprises (SMEs) in Quezon Province and developed a guide on its efficient usage to improve SMEs performance. Descriptive research design was utilized and data were analyzed using weighted mean and Pearson’s correlation coefficient analysis. A total of one hundred fifty–eight (158) management accountants of selected SMEs in Quezon province participated in the survey. The results indicate that the level of influence of the contextual factors of management accounting practices is “very influential” in terms of perceived environmental uncertainty, organizational aspects, strategy and technology. The results of the study provide useful inputs for developing guide to improve business performance to be used by the SMEs in Quezon Province for effective management accounting practices.
Motivational and Emotional Factors Relating to Smartphone Dependence in the Silver-Haired Group from the Perspective of Digital Well-Being
Authors: 钟 智锦 , 纪 晓玉 , 黄 佰全
Published: April 2024

智能手机依赖作为数字实践中功能失调的表现,在银发人群数字融入过程中时常发生。本研究使用结构方程模型对银发群体智能手机依赖的形成机制进行分析,旨在阐释数字化社会中银发群体的数字融入实践及其伴随的数字福祉问题。研究发现,情感因素(孤独感)对银发群体智能手机依赖的直接关联是最稳定的,动机因素对智能手机依赖的直接影响存在内部差异,社会规范、表达需求、信息需求、娱乐需求的直接效果显著,但社交需求不显著,并且上述因素在不同人口特质的银发群体中,作用机制有所差异。研究还讨论了智能手机使用程度的中介效果,发现智能手机使用程度在表达需求和智能手机依赖之间具有稳定的中介效果。
Mediatization and Mediation: The Anglo-Northern European and Latin Traditions of
Media Effects Studies
Authors: 朱 振明
Published: April 2024

在媒介效果研究地形图上存在两个主要传统:盎格鲁北欧传统和拉丁传统。在前者中,“媒介化”逻辑占据主导地位,其以媒介现象学的方式呈现着媒介和社会文化(包括个体和权力)间的构合体验,显现媒介所带来的影响和冲击;而拉丁传统更关注信息流动媒介化末端的中介化效果,认为媒介化更多是话语生产的条件,媒介效果体现于被中介化话语/讯息/信息意义所产生的“象征效用”(德布雷)或“话语权力”(贝隆),此中的“中介化”被视作意义、身份、象征秩序或宏大事件产生的场所(马丁巴贝娄)。在中介化效果中,媒介效果的物质性和话语性不可分割,媒介化成了中介化的必要非充分条件。对两个传统的区分使我们看到,媒介效果的产生不只是一个线性的直接传播过程,更是在这种效果之后所产生的由“认识语法”(贝隆)导致的“影响”,即“话语的权力体现于作为其效果的另一个话语的分析之中”。本研究认为,媒介效果的测量和评估不仅要考察受众的直接态度和反应,更要考察被传话语因当地解读条件特殊性所产生的作为其效果的话语之效用或权力。