bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Polyphenol Patterns of Pleurotus ostreatus Cultivars by UHPLC-ESI-MS/MS; Application of FT-NIR and Chemometric Methods, Classification Options
Authors: Matkovits Anna , Fodor Marietta , Jókai Zsuzsa
Published: January 2024

The nutritional properties of Pleurotus mushrooms were studied to select the varieties with the most favourable properties. These mushrooms have high nutritional value; they are rich in carbohydrates, protein, minerals, vitamins, chitin and reducing compounds, such as phenols and polyphenols. In this study, the polyphenol profiles of thirteen Pleurotus ostreatus cultivars were established by the UHPLC-ESI-MS/MS technique. The results showed that 4-hydroxibenzoic acid, caffeic acid, p-coumaric acid and vanillic acid were the most abundant polyphenolic components in the samples. In addition, the Fourier-transformed near infrared (FT-NIR) spectra of the samples were recorded and evaluated. The correlation between the differences in NIR spectra and the differences in polyphenol patterns of the samples was investigated. The polyphenol results were subjected to several statistical evaluations (Kruskal–Wallis test, Principal Component Analysis (PCA), Spearman correlation analysis, cluster analysis) to detect possible differences between the samples. Relationships between the polyphenol profile and antioxidant capacity (FRAP), total polyphenol content (TPC), free amino acid content (fAA) and the values of each polyphenol component were examined. Based on the results, an effort was made to group the varieties according to the attributes tested.
Managing Pediatric Asthma Exacerbations: The Role of Timely Systemic Corticosteroid Administration in Emergency Care Settings—A Multicentric Retrospective Study
Authors: Antonino Luna , Goossens Eva , van Olmen Josefien , Bael An , Hellinckx Johan , Van Ussel Isabelle , Wouters An , Jonckheer Tijl , Martens Tine , Van Nuijs Sascha , Van Rossem Carolin , Driesen Yentl , Jouret Nathalie , Ter Haar Eva , Rozenberg Sabine , Vanderschaeghe Els , van Steijn Susanne , Verhulst Stijn , Van Hoorenbeeck Kim
Published: January 2024

Background: Asthma is the most prevalent chronic respiratory condition in children. An asthma exacerbation (AE) is a frequent reason for emergency department (ED) visits. An important step in the management of a moderate to severe AE is the administration of systemic corticosteroids (SCS) within 1 h after ED presentation. This study aimed to determine the timing of SCS administration and correlate this with the length of stay and oxygen therapy duration and to explore factors predicting timely administration. Methods: This study used a retrospective multicenter observational design based on electronic medical records review. Children aged < 18 years, presenting to the ED with a moderate to severe AE were included. Results: 205 patients were included. Only 28 patients received SCS within 60 min after ED arrival. The median time to SCS administration was 169 min (Q1 92–Q3 380). A correlation was found between timing and oxygen treatment duration (r = 0.363, p < 0.001) and length of stay (r = 0.368, p < 0.001). No patient characteristics predicted timely SCS administration. Conclusions: Three in four children who presented with a moderate to severe AE at the ED did not receive SCS within the first hour. A prolonged timing of SCS administration correlated with a prolonged length of stay and extended need for oxygen support.
In Situ Evaluation of New Silica Nanosystems as Long-Lasting Methods to Prevent Stone Monument Biodeterioration
Authors: Bartoli Flavia , Hosseini Zohreh , Graziani Valerio , Zuena Martina , Venettacci Carlo , Della Ventura Giancarlo , Tortora Luca , Sodo Armida , Caneva Giulia
Published: January 2024

Microbial colonization can lead to various biodeterioration phenomena in outdoor stone monuments. To prevent these issues and mitigate the negative effects of chemical control, recent research has focused on encapsulating biocides in nanostructures. We tested the antifouling efficiency of the new multifunctional coating through in situ experiments performed on the Aurelian Walls in Rome. We selected two different biocides (2-mercaptobenzothiazole and zosteric sodium salt) and loaded them into two different silica nanocontainers (nanocapsules and mesoporous particles), which were dispersed in TEOS coatings. These coatings were applied to four common lithotypes (marble, travertine, mortar, and brick). Subsequently, we accelerated the colonization by inoculating microorganisms onto half of the samples, subjecting all samples to aging cycles. We conducted colorimetric, infrared spectroscopy, and other microscopic analyses to assess their durability and antimicrobial action. Our 3-year survey indicates that the coatings demonstrated antifoulant efficiency across all samples, with higher effectiveness observed on brick and mortar compared to travertine and marble. Among the nanostructures, nanocapsules exhibited greater efficiency than mesoporous particles, and regarding the biocides, the commercial one outperformed the natural one. These findings highlighted the potential of such systems in preserving cultural heritage; however, further research and product development is imperative for practical implementation.
Changes in Functional Groups and Crystal Structure of Coal Tar Pitch with Respect to Carbonization Temperature
Authors: Lee Sang-Hye , Roh Jae-Seung
Published: January 2024

In this study, changes in the microstructure of coal-tar pitch (CTP) during successive processes, including pyrolysis, polycondensation, and crystallization, were examined in connection with the resulting variations in structure factors, as measured by X-ray diffraction (XRD) analysis, and functional groups, as confirmed by Fourier transform infrared (FTIR) spectroscopy. To this end, four zones were defined based on variations in crystallinity, which were indicated by d002 and Lc. Each zone was further characterized by interpreting crystallinity development in relation to changes in functional groups and specimen height. At around 400 °C, polycondensation occurred as the C-Har and C-Hal peaks decreased in intensity. These peak reductions coincided with the formation of mesophase spheres, resulting in enhanced crystallinity. Subsequently, at around 500 °C, the peak intensity of C-H and COOH decreased, which was attributed to the release of large amounts of gases. This led to sharp volume changes and a temporary reduction in crystallinity. All these results suggest that changes in the functional groups of CTP at lower temperatures (600 °C or less) during the carbonization process are closely associated with variations in its crystallinity. The major findings of the present study provide valuable insights for designing highly effective processes in the manufacturing of synthetic graphite blocks using CTP as a binder material, including by selecting appropriate temperature ranges to minimize volume expansion and crystallinity degradation and determining the lowest possible carbonization temperature to ensure adequate binder strength.
Mechanism of Grain Densification in Nano- and Poly-Crystalline Cu Films and Its Impact in Advanced Metallization Processes
Authors: Cafra Brunella , Alberti Alessandra , Calogero Gaetano , Deretzis Ioannis , Landi Antonio , Pagano Daniele , Sanzaro Salvatore , La Magna Antonino
Published: January 2024

We investigate the microstructural evolution of electrochemically deposited poly-crystalline Cu films during subsequent thermal process cycles at mild maximum temperatures, compatible with the integration in advanced metallization schemes for electronic device manufacturing. The modifications induced by the thermal budget have been characterized at different scales (from the film-substrate interface to the wafer scale) with different complementary techniques: X-ray Diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and dynamical warpage measurements. Moreover, the film internal grains’ evolution has been modelled by a tri-dimensional on-cell model, derived by the Pott-like multi-states configurational energy dependence, able to consider multiple orientation of the grains and densification kinetics in the canonical ensemble. Finally, a macroscopic model of the warpage dependence on the process conditions is discussed. The presented joint theoretical and experimental analysis provides a complete and consistent scenario of the grain densification phenomenon and its impact for the Cu film microstructure and the composite system morphology, indicating several strategies for the integration of the process in real device structures.
Insomnia Guidelines—The European Update 2023
Authors: Riemann Dieter , Dressle Raphael J. , Spiegelhalder Kai
Published: January 2024

The last ten years have seen the development and publication of numerous national and international guidelines devoted to the diagnosis and treatment of insomnia. These include guidelines by the American College of Physicians (ACP), the American Academy of Sleep Medicine (AASM), the British Sleep Society (BSS), the German Sleep Society (GSS), and the European Sleep Research Society (ESRS). Though coming from very diverse authors and backgrounds, these guidelines by and large agree concerning the therapeutic recommendations: cognitive behavioral treatment of insomnia (CBT-I), a multicomponent psychotherapeutic intervention, is unequivocally recommended as a first-line treatment. In this report, we will focus on the most recent guideline update from the ESRS, which was published in November 2023. After suggesting a careful diagnostic procedure, CBT-I, both applied face to face (F2F) or digitally (dCBT-I), is again recommended as a first-line treatment based on the available evidence. Hypnotic medications like benzodiazepines (BZ), benzodiazepine receptor agonists (BZRA), sedating antidepressants, and others are approved for short-term-treatment of up to four weeks. Orexin receptor antagonists (i.e., daridorexant) and prolonged release melatonin are considered as options for longer-term treatment when carefully considering the advantages and disadvantages. Both light therapy and exercise regimens were viewed as promising; however, they still lack convincing evidence for the time being. Given the fact that not every patient responds satisfactorily or even remits following CBT-I or other treatment options, the research agenda calls for the development and evaluation of new therapeutic avenues and combination therapies.
The Application of I-Scan Imaging for Evaluating Benign Vocal Lesions
Authors: Chou Che-Hsien , Chen Chih-Hua , Chen Andy Wei-Ge
Published: January 2024

Current standard methods for evaluating benign vocal lesions, including white light laryngoscopy and video laryngostroboscopy, may struggle to identify smaller lesions. While histopathological results obtained from laryngeal microsurgery provide definitive results, their invasiveness can lead to scarring and impaired phonological outcomes. Intralesional steroid injection has recently gained acceptance, but it lacks pathological diagnostic capabilities. Therefore, there is a growing need for a simple examination that can enhance the diagnosis of benign vocal lesions. NBI, from Olympus Corporation, has shown promising outcomes in detecting and characterizing laryngeal lesions. The i-scan technology by PENTAX, while providing the ability to improve visual clarity during endoscopic procedures, has been addressed less in this field. Our study aims to further investigate the application of i-scan imaging in benign vocal lesions, enrolling patients diagnosed with vocal cysts, polyps, and nodules. We conducted i-scan imaging prior to office-based intralesional steroid injection, assessing the possibility of its providing additional diagnostic information for benign vocal lesions without additional burden.
Visual Versus Digital Color Determination of 3D-Printed Teeth as an Exercise in Dental Students’ Education
Authors: Prause Elisabeth , Hannak Wolfgang B. , Nicic Robert , Jakstat Holger A. , Böning Klaus , Klinke Thomas
Published: January 2024

Visual color determination is part of the daily routine in dental practice. However, it is not a part of dental education so far. The aim of this study was to evaluate whether visual or digital tooth color determination of 3D-printed teeth is a reliable tool for inexperienced dentistry students. Preclinical dental students evaluated eleven 3D-printed, tooth-shaped samples (VarseoSmile Crown plus, BEGO, Bremen, Germany) of different color shades. Visual shade determination using a reference scale (3D-Master Toothguide (3DM_TG), VITA Zahnfabrik, Bad Säckingen, Germany), followed by a digital color determination using a spectrophotometer (VITA Easyshade V, (ES_V), VITA Zahnfabrik), was performed. Color deviation was calculated in the Lab* color space (ΔE00) and converted into CIELAB 2000. The results were evaluated using the Mann–Whitney U test and the Wilcoxon Rank Sum test (α = 0.05). Significant differences between visual and digital color determination were proven (p < 0.001). Visual color determination (3DM_TG) showed a mean deviation (ΔE00 ± 95%CI) of 6.49 ± 0.47. Digital color determination (ES_V) showed significantly lower mean deviations of ΔE00 of 1.44 ± 0.58. Digital tooth color measurement using a spectrophotometer was a more reliable tool for the color determination of 3D-printed teeth for inexperienced dentistry students.
Artfusion: A Diffusion Model-Based Style Synthesis Framework for Portraits
Authors: Yang Hyemin , Yang Heekyung , Min Kyungha
Published: January 2024

We present a diffusion model-based approach that applies the artistic style of an artist or an art movement to a portrait photograph. Learning the style from the artworks of an artist or an art movement requires a training dataset composed of a lot of samples. We resolve this limitation by combining Contrastive Language Image Pretraining (CLIP) encoder and diffusion model, since the CLIP encoder extracts the features from an input portrait in a very effective way. Our framework includes three independent CLIP encoders that extract the text features, color features and Canny edge features from an input portrait, respectively. These features are incorporated to the style information extracted through a diffusion model to complete the stylization on an input portrait. The diffusion model extracts the style information from the sample images in the training dataset using an image encoder. The denoising steps in the diffusion model applies the style information from the training dataset to the CLIP-based features from an input portrait. Finally, our framework produces an artistic portrait that presents both the identity of the input portrait and the artistic style from the training dataset. The most important contribution of our framework is that our framework requires less than a hundred sample images for an artistic style. Therefore, our framework can successfully extract styles from an artist who has drawn less than a hundred artworks. We sample three artists and three art movements and apply these styles to the portraits of various identities and produce visually pleasing results. We evaluate our results using various metrics, including Frechet Inception Distance (FID), ArtFID and Language-Image Quality Evaluator (LIQE) to prove the excellence of our results.
Emerging Trends and Challenges in IoT Networks
Authors: Park Hosung , Park Soochang
Published: January 2024

The nature of novel ICT technologies such as digital twins, various blockchain technologies, AI, technologies beyond 5G and 6G, etc [...]
Catch and Cover Crops’ Use in the Energy Sector via Conversion into Biogas—Potential Benefits and Disadvantages
Authors: Słomka Alicja , Pawłowska Małgorzata
Published: January 2024

The development of civilization is related to an increase in energy demand, while its production is still based mainly on fossil fuels. The release of carbon into the environment, which disturbs the balance of the global system, is the consequence of using these fuels. One possible way to reduce the carbon footprint of the energy sector is the widespread use of cover crops’ biomass for energy production. The aim of this paper is to critically review the knowledge on the dissemination of catch and cover crops’ cultivation in different regions of the world, and the yield, chemical composition and biomethane potential of their biomass. Additionally, the environmental benefits, as well as the challenges and opportunities associated with this biomass use in the energy sector, are considered. The review showed that the aboveground biomass of cover and catch crops is a valuable source for the production of bioenergy in biogas plants. However, the key role of these crops is to prevent soil degradation. Therefore, changes in biomass target use must be preceded by a multi-aspect analysis that allows their impact on the environment to be assessed.
Tungsten Bioaccessibility and Environmental Availability in Tungsten-Spiked Agricultural Soils
Authors: Petruzzelli Gianniantonio , Pedron Francesca
Published: January 2024

Tungsten is an essential element for many cutting-edge industries. Its use is increasing, so much that it has become a “critical element”. With the increase in the use of tungsten, a possible increase in its presence in environmental matrices including soil is expected. In this research, we assessed the environmental availability and bioaccessibility of W in relation to soil properties. Four representative Mediterranean soils, collected in Italy, were spiked with tungsten and incubated for 12 months. In the spiked soils, the environmental availability of the element was determined by the Wenzel sequential extractions. The bioaccessibility was determined by the UBM (BARGE) method in both the gastric and intestinal phases. The findings indicated that the environmental availability is largely influenced by soil properties such as pH and organic matter, while a lower influence was discovered for bioaccessibility, particularly for the gastric phase. These differences could be ascribed to the characteristics of the extractants utilized in the various tests, in particular the pH values. These results could be a valuable reference to integrate with studies on really and not spiked contaminated soils, for the improvement of risk assessments and the development of strategies for remediating soils polluted with tungsten.
Lignin and Cellulose Contents in Chinese Red Pine (Pinus tabuliformis Carr.) Plantations Varied in Stand Structure, Soil Property, and Regional Climate
Authors: Wang Yige , Sun Xiangyang , Li Suyan , Wei Bin
Published: January 2024

The reserve of litter is expected to be reduced on the forest floors of pine plantations dually for the prevention of high risks of forest fires and with a more practical probability of reuse. Lignin and cellulose are the two key constitutive components in litter residues that account for the highest proportion of carbon but are the last to be fully decomposed. The existing trials started examining the mechanisms behind decomposing these two components in response to the combined driving forces of microclimatic factors, forest structure, and stand properties. However, the results were mostly limited to a local-scale ecosystem, and the evidence was reported to be highly scattered across varied conditions globally. Awareness about the combined effects of the driving forces behind the lignin and cellulose contents in the litter of plantations on a large scale is still scarce. In this study, a total of 60 Pinus tabuliformis Carr. plantations (40-year-old) were investigated for their litter quality, regional meteorological factors, soil properties, and stand structure in a provincial area across Liaoning, northeast China. High lignin (40%–43%) and cellulose contents (15%–20%) were found to be located mainly in stands around the biggest city of Shenyang. Rainfall was a key factor that determined the decomposition, but neither the forest structure nor soil nutrient content generated direct effects on the two litter components. The combined factors of low soil pH (~5.8) and high rainfall (~3.0 mm per day) together mainly accounted for the promotion of natural litter decomposition.
Administration of Red Macroalgae (Galaxaura oblongata) in the Diet of the Rainbow Trout (Oncorhynchus mykiss) Improved Immunity and Hepatic Gene Expression
Authors: Yazici Metin , Zavvar Fatemeh , Hoseinifar Seyed Hossein , Nedaei Shiva , Doan Hien Van
Published: January 2024

This study is designed to evaluate the effects of dietary red macroalgae (Galaxaura oblongata) on growth performance, serum, and skin mucus immunological and antioxidant responses in rainbow trout (Oncorhynchus mykiss). For this, rainbow trout were fed diets containing different levels of G. oblongata (0 (ctrl), 0.5 (G1), and 1 (G2) %) for 8 weeks. Following the feeding trial, there were no significant differences in growth performance between the experimental treatments (p > 0.05). Total immunoglobulin (Ig) content and lysozyme (LYZ) activity in serum were increased in fish fed G. oblongata (p < 0.05), with the highest value at (0.5%). Regardless of the inclusion level, mucus total Ig levels were significantly increased in the G. oblongata groups (p < 0.05), and mucus LYZ activity was not changed (p > 0.05). All groups fed G. oblongata showed higher serum catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities than the control group (p < 0.05). However, skin mucus SOD activity increased more in the group fed 1% of G. oblongata than the other groups (p < 0.05). Additionally, the skin mucus GPx activity showed higher values in the group fed 0.5 and 1% G. oblongata than in the control (p < 0.05). No significant differences were recognized between the experimental treatments in terms of CAT activity and malondialdehyde (MDA) concentration (p > 0.05). G. oblongata up-regulated gpx gene expression with the maximum value at the group fed 1% G. oblongata (p < 0.05). Additionally, interleukin 6 (il-6) and tumor necrosis factor-alpha (tnf-α) gene expressions were significantly up-regulated in fish fed 1% compared with the control and 0.5% groups. Based on the results, 0.5–1% G. oblongata can be used in the fish diet and enhance immunity without causing impairment in growth.
Conceptualizing and Validating the Trustworthiness of Maps through an Empirical Study on the Influence of Cultural Background on Map Design Perception
Authors: Gartner Georg , Ignateva Olesia , Zhunis Bibigul , Pühringer Johanna
Published: January 2024

Maps are the culmination of numerous choices, with many offering multiple alternatives. Not all of these choices are inherently guided by default, clarity, or universally accepted best practices, guidelines, or recommendations. In the realm of cartography, it is a distinct feature that individual decisions can be made, particularly regarding data preparation and selection and design aspects. As each map is a product of a multitude of decisions, the confidence we place in maps hinges on the reasonableness of these decisions. The trustworthiness of maps depends on whether these decisions are sound, unquestioned, readily accessible, and supported by dependable groups of decision makers whose reliability can be assessed based on their track record as an institution, reputation, and competence. The advent of user-friendly map-making software and data manipulation tools has placed some of these decisions in the hands of the general populace and those interested in using maps to convey specific agendas. This mirrors other forms of communication and has given rise to a growing discourse on “fake news”, “fake media”, and “fake maps”, ultimately prompting us to question how we can trust the information being conveyed and how we can differentiate between “fake” and “trustworthy” maps. This paper highlights the fundamental aspects determined by the pure nature of cartographic modeling, which influences every attempt to understand, analyze, and express the context and trustworthiness of maps. It then identifies fundamental aspects of trustworthiness with respect to maps. Combining these two fundamental considerations represents an epistemological attempt to identify a research portfolio. An example of an empirical study on identifying selected aspects of this portfolio demonstrates the potential of gaining a better understanding of the context given.
SRBerta—A Transformer Language Model for Serbian Cyrillic Legal Texts
Authors: Bogdanović Miloš , Kocić Jelena , Stoimenov Leonid
Published: January 2024

Language is a unique ability of human beings. Although relatively simple for humans, the ability to understand human language is a highly complex task for machines. For a machine to learn a particular language, it must understand not only the words and rules used in a particular language, but also the context of sentences and the meaning that words take on in a particular context. In the experimental development we present in this paper, the goal was the development of the language model SRBerta—a language model designed to understand the formal language of Serbian legal documents. SRBerta is the first of its kind since it has been trained using Cyrillic legal texts contained within a dataset created specifically for this purpose. The main goal of SRBerta network development was to understand the formal language of Serbian legislation. The training process was carried out using minimal resources (single NVIDIA Quadro RTX 5000 GPU) and performed in two phases—base model training and fine-tuning. We will present the structure of the model, the structure of the training datasets, the training process, and the evaluation results. Further, we will explain the accuracy metric used in our case and demonstrate that SRBerta achieves a high level of accuracy for the task of masked language modeling in Serbian Cyrillic legal texts. Finally, SRBerta model and training datasets are publicly available for scientific and commercial purposes.
Takotsubo Syndrome and Coronary Artery Disease: Which Came First—The Chicken or the Egg?
Authors: Celeski Mihail , Nusca Annunziata , De Luca Valeria Maria , Antonelli Giorgio , Cammalleri Valeria , Melfi Rosetta , Mangiacapra Fabio , Ricottini Elisabetta , Gallo Paolo , Cocco Nino , Rinaldi Raffaele , Grigioni Francesco , Ussia Gian Paolo
Published: January 2024

Takotsubo syndrome (TTS) is a clinical condition characterized by temporary regional wall motion anomalies and dysfunction that extend beyond a single epicardial vascular distribution. Various pathophysiological mechanisms, including inflammation, microvascular dysfunction, direct catecholamine toxicity, metabolic changes, sympathetic overdrive-mediated multi-vessel epicardial spasms, and transitory ischemia may cause the observed reversible myocardial stunning. Despite the fact that TTS usually has an acute coronary syndrome-like pattern of presentation, the absence of culprit atherosclerotic coronary artery disease is often reported at coronary angiography. However, the idea that coronary artery disease (CAD) and TTS conditions are mutually exclusive has been cast into doubt by numerous recent studies suggesting that CAD may coexist in many TTS patients, with significant clinical and prognostic repercussions. Whether the relationship between CAD and TTS is a mere coincidence or a bidirectional cause-and-effect is still up for debate, and misdiagnosis of the two disorders could lead to improper patient treatment with unfavourable outcomes. Therefore, this review seeks to provide a profound understanding of the relationship between CAD and TTS by analyzing potential common underlying pathways, addressing challenges in differential diagnosis, and discussing medical and procedural techniques to treat these conditions appropriately.
Right Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Value of Strain Echocardiography
Authors: Bjerregaard Caroline Løkke , Biering-Sørensen Tor , Skaarup Kristoffer Grundtvig , Sengeløv Morten , Lassen Mats Christian Højbjerg , Johansen Niklas Dyrby , Olsen Flemming Javier
Published: January 2024

Arrhythmogenic right ventricular cardiomyopathy is an inherited cardiomyopathy, characterized by abnormal cell adhesions, disrupted intercellular signaling, and fibrofatty replacement of the myocardium. These changes serve as a substrate for ventricular arrhythmias, placing patients at risk of sudden cardiac death, even in the early stages of the disease. Current echocardiographic criteria for diagnosing arrhythmogenic right ventricular cardiomyopathy lack sensitivity, but novel markers of cardiac deformation are not subject to the same technical limitations as current guideline-recommended measures. Measuring cardiac deformation using speckle tracking allows for meticulous quantification of global systolic function, regional function, and dyssynchronous contraction. Consequently, speckle tracking to quantify myocardial strain could potentially be useful in the diagnostic process for the determination of disease progression and to assist risk stratification for ventricular arrhythmias and sudden cardiac death. This narrative review provides an overview of the potential use of different myocardial right ventricular strain measures for characterizing right ventricular dysfunction in arrhythmogenic right ventricular cardiomyopathy and its utility in assessing the risk of ventricular arrhythmias.
Preliminary Report of Intravenous Tolvaptan Sodium Phosphate (Samtas®) Treatment in Decompensated Heart Failure
Authors: Nakamura Makiko , Imamura Teruhiko , Kinugawa Koichiro
Published: January 2024

Background: Tolvaptan sodium phosphate (Samtas®; Otsuka Pharmaceutical, Tokyo, Japan) is a novel intravenous aquaretic diuretic aimed at individuals experiencing advanced congestion refractory to conventional diuretics and having difficulty with oral intake. Despite its potential, the true efficacy and practicality of this compound within real-world clinical settings remain obscure. Methods: A retrospective analysis of clinical data was conducted, examining trends among consecutive in-hospital patients diagnosed with congestive heart failure who underwent treatment with tolvaptan sodium phosphate at a prominent academic medical center between June 2022 and June 2023. Results: Twenty-one patients were enrolled (median age: 75 years, serum N-terminal pro B-type natriuretic peptide: 8941 pg/mL). Among them, 14 patients (67%) received non-invasive/invasive positive-pressure ventilation, and 17 patients (81%) concurrently received intravenous inotropes. Subsequent to the initiation of tolvaptan sodium phosphate treatment, a significant increase in urine volume was observed on the following day (p = 0.036). Urine osmolality decreased from 356 (318, 443) at baseline to 247 (176, 333) mOsm/kg after 4 h (p = 0.002). No occurrences of hypernatremia were recorded during the therapeutic period. Notably, two patients transitioned from tolvaptan sodium phosphate treatment to continuous hemodiafiltration due to insufficient efficacy. Conclusions: In routine clinical practice, intravenous tolvaptan sodium phosphate exhibits potential efficacy and practicability in the majority of congestive heart failure patients exhibiting refractory congestion, unstable hemodynamics, and challenges with oral intake.
Current Evidence Regarding Shoulder Instability in the Paediatric and Adolescent Population
Authors: Rawal Aziz , Eckers Franziska , Lee Olivia S. H. , Hochreiter Bettina , Wang Kemble K. , Ek Eugene T.
Published: January 2024

Paediatric and adolescent shoulder instability is caused by a unique combination of traumatic factors, ligamentous laxity, and pattern of muscle contractility. The multifactorial nature of its aetiology makes interpretation of the literature difficult as nomenclature is also highly variable. The purpose of this review is to summarize the existing literature and shed light on the nuances of paediatric and adolescent shoulder instability. The epidemiology, clinical features, imaging, and management of all forms of paediatric shoulder instability are presented. The main findings of this review are that structural abnormalities following a dislocation are uncommon in pre-pubertal paediatric patients. Young post-pubertal adolescents are at the highest risk of failure of non-operative management in the setting of traumatic instability with structural abnormality, and early stabilisation should be considered for these patients. Remplissage and the Latarjet procedure are safe treatment options for adolescents at high risk of recurrence, but the side-effect profile should be carefully considered. Patients who suffer from instability due to generalized ligamentous laxity benefit from a structured, long-term physiotherapy regimen, with surgery in the form of arthroscopic plication as a viable last resort. Those who suffer from a predominantly muscle patterning pathology do not benefit from surgery and require focus on regaining neuromuscular control.
Comparison of Tooth Size Measurements in Orthodontics Using Conventional and 3D Digital Study Models
Authors: Petrović Valentina , Šlaj Martina , Buljan Mia , Čivljak Tadej , Zulijani Ana , Perić Berislav
Published: January 2024

(1) Background: The objective of this study was to assess which digitization method produces the biggest deviation in the 3D images of tooth size from plaster models made using alginate impressions, which are considered the gold standard in orthodontics. (2) Methods: The sample used in this study included 30 subjects (10 males and 20 females). Measurements were made on four types of models: (1) digital models obtained through intraoral scanning and digitized models of plaster cast made from (2) alginate impressions, (3) silicone impressions, and (4) conventional plaster models. Mesio-distal (MD) and buccal/labial–lingual/palatal (BL) dimensions were measured on the reference teeth of the right side of the jaw (central incisor, canine, first premolar, and first molar). Comparisons of tooth size between the methods were conducted using a repeated measurement analysis of variance and the Friedman test, while the intraclass correlation coefficient was used to determine agreement between the different methods. (3) Results: The results showed a similar level of agreement between the conventional and digital models in both jaws and the anterior, middle, and posterior segments. Better agreement was found for the MD measurements (r = 0.337–0.798; p ≤ 0.05) compared to the BL measurements (r = 0.016–0.542), with a smaller mean difference for MD (0.001–0.50 mm) compared to BL (0.02–1.48 mm) and a smaller measurement error for MD (0.20–0.39) compared to BL (0.38–0.89). There was more frequently a better level of agreement between 3D images than measurements made using a digital caliper on the plaster models with 3D images. (4) Conclusions: The differences in measurements between the digital models and conventional plaster models were small and clinically acceptable.
Facile Green Synthesis of α-Bismuth Oxide Nanoparticles: Its Photocatalytic and Electrochemical Sensing of Glucose and Uric Acid in an Acidic Medium
Authors: Alam Mir Waqas , Allag Nassiba , Utami Maisari , Waheed-Ur-Rehman Mir , Al Saleh Al-Othoum Mohd , Sadaf Shima
Published: January 2024

The nanocrystalline bismuth oxide (Bi2O3) was produced utilizing a green combustion process with Mexican Mint gel as the fuel. The powder X-ray diffraction (PXRD) method proved the nanocrystalline nature and Bi2O3 nanoparticles (BONPs) in α phase and the average crystalline size of BONPs nanoparticles has been found to be 60 nm. The spherical-shaped structure with bright dot-like spots in the center of the selected area diffraction (SAED) is confirmed by the scanning electron microscopy (SEM) and Energy dispersive X-ray spectroscopy (EDAX) in conjunction with the transmission electron microscopy (TEM) and high-resolution transmission electron microscopy (HRTEM) demonstrating the crystalline behavior of green NPs. The Kubelka-Monk function was used to analyze diffuse reflectance spectra, and the results revealed that BONPs have a band gap of 3.07 eV. When utilized to evaluate the photocatalytic capabilities of NPs, the direct green (DG) and fast orange red (F-OR) dyes were found to be activated at 618 and 503 nm, respectively. After 120 min of exposure to UV radiation, the DG and F-OR dyes’ photodegradation rate reduced its hue by up to 88.2% and 94%, respectively. Cyclic voltammetry (CV) and electrochemical impedance techniques in 0.1 N HCl were used to efficiently analyze the electrochemical behavior of the produced BONPs. A carbon paste electrode that had been enhanced with BONPs was used to detect the glucose and uric acid in a 0.1 N HCl solution. The results of the cyclic voltammetry point to the excellent electrochemical qualities of BONPs. Bi2O3 electrode material was found to have a proton diffusion coefficient of 1.039 × 10−5 cm2s−1. BONP exhibits significant potential as an electrode material for sensing chemicals like glucose and uric acid, according to the electrochemical behavior.
Dynamic Response Mechanism of Thin-Walled Plate under Confined and Unconfined Blast Loads
Authors: Yao Shujian , Chen Yikai , Sun Chengming , Zhao Nan , Wang Zhonggang , Zhang Duo
Published: January 2024

Thin-walled metal plates and cabin structures are widely found in ships and cargos which are susceptible to attacks or accidental explosions. The present work focuses on the dynamic response mechanism of steel plates under unconfined and confined blast loads. In the experiment, digital image correlation (DIC) technique was applied to record and analyze the dynamic response process of a large-scale field blast test. The DIC measured curve and the numerically calculated curves agree well in both trends and peak values. Then, the dynamic response mechanisms of steel plates under an unconfined blast (UB) load and confined blast (CB) load were compared and discussed. The results show that the dynamic response of plates can be divided into three phases under both UB and CB loads, with different mechanisms. In phase I, plastic hinges start from the center and move to the boundary in the UB condition, while in the case of CB, plastic hinges occur close to the boundary and move in the opposite direction. In phase II, two plastic hinge lines propagate towards each other, a platform exists between the boundary, and the central area remains undeformed in the UB condition, while in the CB condition, larger deformation occurs in the peripheral region rather than the central area.
Life Cycle Assessment of Utilizing Bio-Oil to Reduce the Carbon Footprint on the Yangtze River Mainline: A Case Study of Container Ships
Authors: Li Chaoran , Zhu Yingying , Zhu Jinyuan , Zhao Yifan , Chen Geng
Published: January 2024

In the context of ecological protection and strict emissions control, the replacement of traditional energy sources with clean energy has become a new direction for the development of the shipping industry. Bio-oil is beneficial to reduce greenhouse gas (GHG) emissions and air pollutants. In this study, life cycle assessment (LCA) and life cycle cost assessment (LCCA) are conducted to evaluate the environmental and economic impacts of diesel and bio-oil as fuel for container ships in the Yangtze River mainline. The results show that compared with diesel, the total greenhouse gas emission is 34.58% lower than diesel, and the total cost is 8.22% higher than that of diesel throughout the whole life cycle of these two fuels. Both LCA results and LCCA results show that bio-oil is an ideal clean energy source. In addition, the abundant raw material resources of bio-oil make it a reliable alternative, which is also of great significance.
Role of the osaA Gene in Aspergillus fumigatus Development, Secondary Metabolism and Virulence
Authors: Dabholkar Apoorva , Pandit Sandesh , Devkota Ritu , Dhingra Sourabh , Lorber Sophie , Puel Olivier , Calvo Ana M.
Published: January 2024

Aspergillus fumigatus is the leading cause of aspergillosis, associated with high mortality rates, particularly in immunocompromised individuals. In search of novel genetic targets against aspergillosis, we studied the WOPR transcription factor OsaA. The deletion of the osaA gene resulted in colony growth reduction. Conidiation is also influenced by osaA; both osaA deletion and overexpression resulted in a decrease in spore production. Wild-type expression levels of osaA are necessary for the expression of the conidiation regulatory genes brlA, abaA, and wetA. In addition, osaA is necessary for normal cell wall integrity. Furthermore, the deletion of osaA resulted in a reduction in the ability of A. fumigatus to adhere to surfaces, decreased thermotolerance, as well as increased sensitivity to oxidative stress. Metabolomics analysis indicated that osaA deletion or overexpression led to alterations in the production of multiple secondary metabolites, including gliotoxin. This was accompanied by changes in the expression of genes in the corresponding secondary metabolite gene clusters. These effects could be, at least in part, due to the observed reduction in the expression levels of the veA and laeA global regulators when the osaA locus was altered. Importantly, our study shows that osaA is indispensable for virulence in both neutropenic and corticosteroid-immunosuppressed mouse models.
Integrated Flood Impact and Vulnerability Assessment Using a Multi-Sensor Earth Observation Mission with the Perspective of an Operational Service in Lombardy, Italy
Authors: Righini Margherita , Gatti Ignacio , Taramelli Andrea , Arosio Marcello , Valentini Emiliana , Sapio Serena , Schiavon Emma
Published: January 2024

The frequency and the accumulation of medium–small flood events can cause severe impacts. In a climate change context, real-time monitoring and a fast risk assessment are needed to support the post-disaster phases. The present work presents a novel methodology that leverages the potential of earth observation data to produce a proof-of-concept for flood vulnerability assessment, serving as the basis for a Map Operational Service for the Lombardy region. The proof-of-concept is related to both flood hazard estimation and vulnerability assessment, considering the evaluation of the potentialities of the synthetic aperture radar data when used to feed a downstream service. Using the city of Pavia (Italy), which was affected by a flood event in November 2019, as a case study, we present an integrated flood impact approach that includes a combination of social and physical parameters. The results contribute to a processing chain designed as a pre-operational service where each data analytic retrieves thematic products to support the exposure and damage estimates based on earth observation-derived hazard products for emergency and recovery responses. Three different satellites covered more than 40 h of the flood’s evolution, supporting the great potential of the multi-sensor approach. Therefore, different sensor configurations in terms of spectral bands (X and C bands) and resolutions (from 10 to 1 m) provide a near real-time view of the event. Comparing the results obtained through the three hazard scenarios, a final social and physical Integrated Impact Index is obtained. The added value information leads to the determination of hotspots with which to prioritize effective interventions during emergency and recovery phases, crucial for capturing inherent conditions that allow communities to absorb impacts and cope with a damaging flood event.
A Step from Vulnerability to Resilience: Restoring the Landscape Water-Storage Capacity of the Great Hungarian Plain—An Assessment and a Proposal
Authors: Timár Gábor , Jakab Gusztáv , Székely Balázs
Published: January 2024

The extreme drought in Europe in 2022 also hit hard the Great Hungarian Plain. In this short overview article, we summarize the natural environmental conditions of the region and the impact of river control works on the water-retention capacity of the landscape. In this respect, we also review the impact of intensive agricultural cultivation on soil structure and on soil moisture in light of the meteorological elements of the 2022 drought. The most important change is that the soil stores much less moisture than in the natural state; therefore, under the meteorological conditions of summer 2022, the evapotranspiration capacity was reduced. As a result, the low humidity in the air layers above the ground is not sufficient to trigger summer showers and thunderstorms associated with weather fronts and local heat convection anymore. Our proposed solution is to restore about one-fifth of the area to the original land types and usage before large-field agriculture. Low-lying areas should be transformed into a mosaic-like landscape with good water supply and evapotranspiration capacity to humidify the lower air layers. Furthermore, the unfavorable soil structure that has resulted from intensive agriculture should also be converted into more permeable soil to enhance infiltration.
Impact of Urbanization on the Sustainable Production of Regional Specialty Food: Evidence from China’s Potato Production
Authors: Ni Yinfeng , Li Zhi , Li Jingdong , Jian Yuqing
Published: January 2024

The rapid urbanization process has gradually deepened its role in the sustainable development of agriculture, especially in the sustainable supply of food in poor areas, and has attracted more attention from international academic circles. However, the impact mechanism of different dimensions of urbanization on food sustainability in poor areas has not yet been fully unpacked. Therefore, this study focuses on potatoes as a specialty food mainly grown in poor areas of China, explores the impact mechanism of urbanization on the carbon emission intensity of potato production (CEIPP) with the spatial Durbin model, and compares with the carbon emission intensity of staple grain (CEISG) results. The main conclusions are as follows: the urbanization of main potato-producing areas developed rapidly from 2002 to 2020, which is in line with the decrease in CEIPP. The decrease in CEIPP has a significant impact on slowing down the growth of total carbon emissions and has greater potential for reduction, especially in Central and Western China, which has a large poverty-stricken population. Compared with traditional staple grain, urbanization has become a key factor influencing CEIPP. The results indicate that different dimensions of urbanization have varying degrees of impact on the sustainable production of regional specialty foods in China. The improvement of comprehensive urbanization, population urbanization, and economic urbanization reduces CEIPP, while land urbanization increases CEIPP. Therefore, to reduce CEIPP and promote its sustainable development, it is necessary to improve population urbanization and economic urbanization, properly avoid the disorderly expansion of land urbanization, and improve the quality and level of comprehensive urbanization.