bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepción de las personas en niños y niñas de 10-12 años: comparación con otros grupos etarios
Authors: Roselli Néstor Daniel
Published: September 2024

La percepción de las personas por medio de categorías identificatorias descriptivas (como el sexo, la edad, y la apariencia física, psicológica y social) es un proceso psicológico básico que permite ordenar la realidad y regular el comportamiento social. Para la psicología del desarrollo resulta de gran interés estudiar la evolución de este proceso a lo largo de las distintas edades de la vida, y es por esto que en la presente investigación se estudia dicha percepción en el caso de los niños y niñas, en el marco de otros estudios realizados con jóvenes, adultos y adultos-mayores. Para ello, se contó con la participación de 60 niños de 10-12 años de edad, que realizaron individualmente cuatro tareas: (a) describir libremente el contenido de cuatro fotos de personas (una niña, un señor adulto, un muchacho joven y una señora adulta mayor); (b) dividir un set de ocho fotos de personas adultas y adultas mayores (varones y mujeres, serias y sonrientes, con vestimenta formal e informal, con y sin accesorios) en dos grupos a partir de un criterio clasificatorio; (c) dividir una serie etaria continua de siete fotos (niña-anciano) en dos y tres grupos; y (d) calcular los años de edad de cinco de las siete fotos anteriores (joven, adulto, adulto joven, adulto mayor, adolescente). Los resultados muestran que las categorías objetivas, como edad, sexo, vestimenta y rasgos físicos, son las más recurrentes, en comparación con las categorías subjetivas o inferenciales. Esto se explica tanto por razones evolutivas, como sociales. Los resultados se comparan con los hallazgos de estudios con muestras de otros grupos etarios.
Qualitative Lipschitz to bi-Lipschitz decomposition
Authors: Bate David
Published: September 2024

We prove that any Lipschitz map that satisfies a condition inspired by the work of G. David may be decomposed into countably many bi-Lipschitz pieces.
Exchanging “Mementos of Death”: Holocaust Remains in Poland and Japan
Authors: Zwigenberg Ran , Dziuban Zuzanna
Published: September 2024

In 1962, a Japanese delegation of peace activists visited Auschwitz-Birkenau where they participated in the annual ceremony commemorating the liberation of the camp. As part of the ceremony, the delegation engaged in an exchange of Hiroshima and Auschwitz “memontos,” receiving from the Polish side, amongst others, an urn containing ashes of the victims of the camp. The exchange was the first of several that included Holocaust urns, most of which are now in Japan, and a part of a much broader phenomenon of material dispersal of human remains instituted by Polish museums established at the former Nazi camps. In this paper, we take a critical look at this practice, its development, directionalities and meanings. Tracing the journey of the urns and their various uses, we argue, reveals the complex politics and cultural landscape of the transnational commemoration of World War II in its very local meanings in Poland, Japan and beyond.
Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
Authors: Yuan Haichuan , Huang Min , Liu Tao , Song Wu , Luo Chengpeng
Published: September 2024

Objective

To investigate the effect of three-dimensional (3D) reconstruction-assisted cognitive fusion in targeted prostate biopsy.

Results

There was no significant difference in the detection rate of prostate cancer (PCa) between targeted biopsy and systematic biopsy, and there was significant difference in the detection rate of clinically significant prostate cancer (csPCa) between targeted biopsy and systematic biopsy. In the low prostate total specific antigen (tPSA) group, there was no statistically significant difference in the detection rate of prostate cancer between the two biopsy modalities. However, compared with systematic puncture, targeted puncture had a higher detection rate for csPCa and a lower detection rate for clinically insignificant prostate cancer (ciPCa), and the difference was statistically significant. In the high tPSA group, there was no significant difference in the detection rate of PCa, csPCa, and ciPCa between the two biopsy types. Single needle positive rate of targeted puncture (29.77%) was significantly higher than that of systematic puncture (10.28%).

Conclusions

The detection rate of csPCa in 3D reconstruction-assisted cognitive fusion targeted prostate biopsy is better than that of 12-needle systematic biopsy, which markedly improved the positive rate of prostate biopsy.
Hibiscus sabdariffa L. petal biomass: A green source of nanoparticles of multifarious potential
Authors: Tasnim Ashfia , Roy Anik , Akash Saydur Rahman , Ali Hanif , Habib Mohammad Rowshanul , Barasarathi Jayanthi , Muthukumaran Munusamy , Sayyed R. Z. , Yeasmin Tanzima
Published: September 2024

Plant biomass is the largest and amply available biomass on the earth. Petals of flowering plants serve as an excellent raw material to synthesize nanoparticles. Biologically prepared silver nanoparticles (AgNPs) have garnered interest due to their simple and cost-effective green approach compared to chemical and physical methods. This investigation aimed to analyze the antibacterial, antioxidant, and antibiofilm properties of AgNPs synthesized from Hibiscus Sabdariffa L. petal extract and assess their potential as a stabilizing agent. A surface plasmon resonance peak at 421 nm confirmed the formation of AgNPs in the ultraviolet–visible (UV–vis) range. Additionally, size and morphological studies of the AgNPs were obtained using Scanning electron microscope (SEM) and X-ray diffraction (XRD) techniques. The identification of functional groups that are responsible for the stabilizing layer of AgNPs was achieved through Fourier transform infrared spectroscopy (FTIR) analysis. The antioxidant activity of synthesized AgNPs was investigated using the DPPH and ABTS radicals; the best performance was found in the scavenging of the DPPH radical, with an IC50 value of 37.71 ± 0.07 μg/ml. AgNPs actively suppressed the growth of four pathogenic bacteria (Shigella dysenteriae, Shigella boydii, Staphylococcus aureus, and Escherichia coli). Notably, Escherichia coli biofilm formation was absent at 40 and 80 g/ml of AgNPs up to 96 h. Finally, the overall findings of this present study confirmed that the AgNPs prepared from Hibiscus Sabdariffa petal extract can be used as antioxidant, antimicrobial, and antibiofilm preparations.
Molecular approach to semiconductors: a shift towards ecofriendly manufacturing and neuroinspired interfaces
Authors: Monakhov Kirill Yu. , Meinecke Christoph , Moors Marco , Schmitz-Antoniak Carolin , Blaudeck Thomas , Hann Julia , Bickmann Christopher , Reuter Danny , Otto Thomas , Schulz Stefan E. , Parala Harish , Devi Anjana
Published: September 2024

Energy dissipation through physical downscaling towards more complex types of memory and logic devices, loss of ultrapure water and consumption of large amounts of (toxic) chemicals for wafer cleaning processes, as well as high thermal budget of solid-state synthesis and thin film growth of standard semiconductors including the use of rare earth elements – all this poses great challenges for semiconductor materials science and technology. Therefore, research and development of alternative methods for micro- and nanofabrication and chemical functionalization of a new type of resource- and energy-efficient semiconductors as the core component of every computer chip is crucial. One of the promising opportunities is the transformation of today’s complementary metal-oxide-semiconductor (CMOS) electronics into ecofriendly and neuroinspired electronics driven by molecular design and multi-level switching mechanisms at room temperature. The sustainable chemical technology of electron transport and switching materials in semiconductor manufacturing and the development of devices with new unconventional nanophysics, improved performance, and augmented functionalities (beyond-CMOS and More-than-Moore) is becoming increasingly important in the context of a gradual transition to a future-oriented concept of Internet of Everything (IoE). In this article, we focus on the technological significance of semiconductor preparation from single-source (molecular) precursors and the prospect of functionalizing semiconductors using DNA origami nanotechnology and stimuli-responsive metal–oxygen cluster ions such as polyoxometalates (POMs). We also describe the advanced characterization of these qualified molecular systems by soft X-rays. We emphasize the technical relevance of using solution-based methods for the bottom-up preparation of novel and hybrid semiconductors as well as their challenging scalability and the compatibility of methods of molecular technology with lithography-based mass production. Our article aims to contribute to the achievement of the United Nations’ Sustainable Development Goal 9 (Industry, Innovation and Infrastructure).
Material Characterisation of 19–20th Century Manuscripts from Northern Thailand
Authors: Sathiyamani Sowmeya , Ngiam Sean , Bonnerot Olivier , Jaengsawang Silpsupa , Panarut Peera , Helman-Wazny Agnieszka , Colini Claudia
Published: September 2024

Material analysis was carried out on four manuscripts from Northern Thailand, which included two palm-leaf manuscripts and two paper manuscripts. The two palm-leaf manuscripts MS 6 and MS 7 were found to have been written in the traditional method, wherein text was incised on the surface of the leaves, and then soot applied to the surfaces, confirmed by the identification of carbon ink. MS 7 additionally showed the presence of trace levels of iron in the ink, either from soot paste or from the stylus used for inscribing. The paper manuscript MS 3 was written in iron-gall ink, with sections written using a methyl-violet based ink while MS 4 was written in carbon ink. The paper used in the case of MS 3 was found to be machine made, while khoi fibres (Streblus asper) were used for making the paper used for MS 4. A combination of traditional and modern pigments, like molybdenum orange, was used for decorating the edges and cover. The results improved our understanding of these manuscripts in particular, and also provided us with insights about the rapid adoption of modern materials and their incorporation into the production of written artefacts from Northern Thailand in the late 19th and early 20th centuries.
FORMOR project: analysis of the formation of complex societies in Early Medieval Moravia
Authors: Macháček Jiří , Sládek Vladimír , Balcárková Adéla , Dresler Petr , Hofmanová Zuzana , Ingrová Pavlína , Košťál Martin , Nosek Vojtěch , Prišťáková Michaela , Přichystalová Renáta , Zlámalová Denisa
Published: September 2024

In the ninth century AD, Moravia (now in Czechia) was the heartland of the first Slavic state-like formation in Central Europe. Traditionally, the archaeology of the region has been interpreted via historical records only; the FORMOR project aims to broaden this view by using archaeometry, archaeogenetics, bioarchaeology and introducing new theoretical approaches.
Long-term prehistoric human occupation in Western Tibet: excavations and surveys at the Xiada Co site
Authors: Chen Xinzhou , Li Ziyan , Xu Hailun , Zhang Zhengwei , Wu Jingman , Tsring Tinley , Lü Hongliang
Published: September 2024

The complexity of the settlement pattern of hunter-gatherers is an underexplored issue in Tibetan archaeology; the multi-year survey and excavations at the Xiada Co site aim to address this situation. The project has provided evidence of long-term human occupation since the Early Holocene and has revealed the earliest human residential structures in Tibet.
Persistent Impact of Prior Experience on Spatial Learning
Authors: Awh Michelle P. , Latimer Kenneth W. , Zhou Nan , Leveroni Zachary M. , Poon Anna G. , Stephens Zoe M. , Yu Jai Y.
Published: September 2024

Learning to solve a new problem involves identifying the operating rules, which can be accelerated if known rules generalize in the new context. We ask how prior experience affects learning a new rule that is distinct from known rules. We examined how rats learned a new spatial navigation task after having previously learned tasks with different navigation rules. The new task differed from the previous tasks in spatial layout and navigation rule. We found that experience history did not impact overall performance. However, by examining navigation choice sequences in the new task, we found experience-dependent differences in exploration patterns during early stages of learning, as well as differences in the types of errors made during stable performance. The differences were consistent with the animals adopting experience-dependent memory strategies to discover and implement the new rule. Our results indicate prior experience shapes the strategies for solving novel problems, and the impact of prior experience remains persistent.
A Course-Based Undergraduate Research Experience (CURE) using a Viral Emerging Amphibian Infection
Authors: Duffus Amanda L. J. , Sanders Anne
Published: September 2024

At many undergraduate institutions it is not possible for every student to participate in one-on-one student-faculty research experiences. However, large numbers of undergraduates could gain research experience through the use of course-based undergraduate research (CURE) in laboratory courses. Here we present a CURE using a viral emerging infection in amphibians that is suitable for undergraduate-level students and will permit them to develop an understanding of how to calculate epidemiologically relevant sample sizes, genomic DNA extraction procedures, traditional or quantitative PCR use, and associated techniques.
The Science of Disney’s Strange World
Authors: Touchet Blake
Published: September 2024

Disney’s Strange World offers an accessible and engaging entry point for students to interact with biological concepts and processes. This article will discuss some of the analogs represented in the film, educator tips for using audiovisual media in the science classroom, and questions that teachers can use to allow students to critique the film’s representations of scientific concepts.
Hands-on Activities to Engage Students in Muscle Cell Structure and Function
Authors: Galicia Maricela , Kao Robert M.
Published: September 2024

Student-centered learning of biology concepts through hands-on tactile approaches is one of the important themes in inclusive and equitable STEM teaching. In our article, we describe the development of clay Velcro origami models for students to explore the molecular and cellular process of muscle fiber formation. We repurposed dollar store items and recyclable items used to construct a variety of textures in the clay Velcro model of early and late stages of muscle fiber formation. These hands-on activities are linked to the Next Generation Science Standards (NGSS) on using a model to explore the cell and structure changes to form a multinucleated muscle fiber or the formation of a syncytium. Finally, we also illustrate how students can utilize the clay Velcro model to make predictions if key molecules in cell fusion do not work during the process of syncytial formation during muscle fiber development.
La pedagogía crítica no es una receta: Estrategias, desafíos y aportes en la enseñanza de los Estudios Sociales. Entrevista con el Dr. E. Wayne Ross
Authors: Granados Gamboa Karol , Granados Trejos Anderson , Rodríguez Víquez Lady Pamela
Published: September 2024

This article presents the results of an interview with Dr. E. Wayne Ross, who is a professor and researcher at the University of British Columbia in Vancouver, Canada. He has also worked with various institutions such as the State University of New York, the University of Louisville, and Binghamton University. His areas of interest include social studies education, curriculum studies, democratic education, and critical pedagogy. The interview with Dr. Ross is focused on various conceptualizations surrounding critical pedagogy, as well as the contributions, challenges, and obstacles involved in a critical approach to social studies education. Additionally, the interview explored strategies that teachers can implement in their classrooms to break away from the traditional education paradigms.
Pensar casos de prácticas sociales genocidas para formar ciudadanía que defienda los derechos humanos. Aportes desde la educación geográfica
Authors: María Cristina Nin
Published: September 2024

This paper presents reflections on the approach in secondary education to cases of genocidal practices at different geographical scales. In Argentina, the teaching of the social sciences and geography is necessarily articulated with the Education and Memory Program (2006). However, the current reality challenges us in the exercise of teaching with conflicts that are not explicit in the curriculum. The genocides that occurred in the 20th century and in the present are a territorial problem and, therefore, commit geographic researchers and teachers to approach them from a multidimensional perspective. The role of teachers as creators of emerging agendas is considered key to decolonize the hegemonic curriculum and current editorial proposals and in the formation of citizenship.
Desafíos de la formación ciudadana en México, Costa Rica y Perú: un abordaje desde la experiencia docente
Authors: Meléndez Montero Arturo , Cazarín Callejas Michelle de Jesús , Tantas Rayme Juana María
Published: September 2024

This article presents an analysis of the experiences of three Latin American teachers belonging to Mexico, Costa Rica and Peru, based on the narratives of the subjects, an approach is made to the situation in citizenship education in the region, pointing out the problems and obstacles they present. The formal educational systems and the curricula of the various subjects related to academic citizenship education in Latin American countries when the objective set by the teachers is the formation of active and progressive critical citizenships in response to a context of growing authoritarianism and conservatism by Lastly, it is explained how these obstacles represent challenges that condition but do not fully determine their margin of action in educational spaces, thus highlighting pedagogical work as a possible agent of social transformation.
Mechanical and thermophysical properties of concrete with straw fiber and straw ash
Authors: Wen Liang , Yan Changhong , Shi Yehui , Wang Zhenxiang
Published: September 2024

China has abundant straw resources; however, the utilization of straw waste resource remains challenging. In this work, corn straw fiber and corn straw ash were applied to concrete as raw material after pretreatment. Through mechanical and thermal conductivity tests, it was concluded that the tensile strength of the corn straw fiber was 160.5 MPa after alkali treatment. The corn straw fiber and corn straw powder did not enhance the compressive strength of concrete. Compared with original concrete, the thermal conductivity of concrete added with 1.5% corn straw powder decreased by 25.9%, and the thermal conductivity of concrete with 5% corn straw ash was reduced by only 5.2%. Through thermogravimetric analysis of the concrete, it was found that the internal weakly bound water and strongly bound water will be lost in the range 100 °C to 160 °C, Ca(OH)2 will decompose from 420 °C to 500 °C, and CaCO3 will decompose approximately at 800 °C. It is recommended that corn straw powder and corn straw ash can be added at 1.5% and 5% concentrations to ensure that the mechanical properties can meet the engineering requirements and achieve good insulation performance.
The individualization of estimation of changes in the reaction of the cardiovascular system to the procedure of manual therapy of the thoracic spine in men with a vertebral thoracalgia in the sanatorium-resort treatment’ course
Authors: Panenko Anatolii , Romanchuk Oleksandr
Published: September 2024

Purpose

The purpose of this study was to evaluate the reaction of the cardiovascular system of men with vertebral thoracalgia to manual therapy procedures on the chest during the course of sanatorium-resort treatment of spinal osteochondrosis.

Material and methods

Under supervision were 26 men aged 32.3 (27.9; 42.9) years who underwent a course of sanatorium-resort treatment for vertebral thoracalgia in the clinical sanatorium named after V.P. Chkalov (Odesa, Ukraine) in 2010-2011. The treatment complex included of 4 thoracic spine manual therapy (TSMT) procedures, which were performed every 5-7 days of sanatorium-resort treatment. The indicators of the cardiovascular system were recorded using the Omron M1 Classic device (Japan) in a supine position before and after every procedure TSMT.

Results

The results obtained in this study indicated sufficiently characteristic significant changes in heart rate (min-1), which mainly decreases, DBP (mm Hg), which mainly increases, PBP (mm Hg), which mainly decreases in each of the procedures TSMT in men with vertebral thoracalgia.

Separately, according to the data of the rank evaluation of changes in indicators, the types of response of the contractile function of the heart (Δ Double product) and autonomic support of hemodynamics (Δ Index Kerdo) in men were characterized. They showed that there are individual differences in response to the TSMT procedure in the course of sanatorium-resort treatment.

Conclusion.

Determining the changes in Δ Double product and Δ Index Kerdo for the procedure of manual therapy of the thoracic spine made it possible to develop criteria for evaluating the types of response of the contractile function of the heart and autonomic support of hemodynamics. Their analysis in the course of sanatorium treatment of patients with thoracalgia showed that there are individual characteristics of reactions that should be taken into account in order to prevent the occurrence of negative effects of the TSMT procedure.
Bigrams in the Terminological Thesaurus of the Gospel Text by F. M. Dostoevsky
Authors: Borisova Valentina
Published: September 2024

Along with the glossary, the article describes the graph models of the terminological thesaurus of the Gospel text by F. M. Dostoevsky, based on the clustering of bigrams as the most stable paired word combinations and with regard to the totality of their discursive features, including frequency of use, proximity in texts and semantic similarity. The identification and analysis of such bigrams as conceptual points of a terminological thesaurus is important for its network visualization, thanks to which it is clear in which conceptual conjugation key terms function, how they are distributed among certain thematic clusters. One cluster may contain terms from different discourses. This is an important indicator of how the terms are conjugated, and how integral, despite its interdiscursive nature, the metalanguage of modern studies of the Gospel text by F. M. Dostoevsky is. That is, in this case the terminological thesaurus performs a diagnostic and predictive role in modeling a scientific language.
How to use alternative medicine in the 21st century part II
Authors: L Burkett Dr Rebecca
Published: September 2024

Alternative and Natural Medicine are nonmedical techniques and therapies that help a client heal faster and uses non-medication for the mind, body, and soul. Also, Holistic perspectives, this provides a framework for understanding how sentient beings, including humans, perceive and interact with the world. In the Holistic study these guidelines are for us to follow, and they are the: The Six Universal Reality Dimensions, as presented in the Theory of Holistic Perspective, they describe the fundamental aspects through which all sentient beings perceive and engage with reality.
As materialidades da cultura digital e a questão do Antropoceno
Authors: Souza Aguiar Carlos Eduardo , Melo da Silva Dayana Karla
Published: September 2024

A emergência da cultura digital e a entrada em cena do Antropoceno são duas significativas características da contemporaneidade. Enquanto a primeira se refere às múltiplas interações e agenciamentos engendrados pelas tecnologias digitais e em rede, a segunda concerne ao impacto das ações humanas no ambiente global, impulsionado, no atual contexto, por essas mesmas tecnologias. O objetivo deste artigo é investigar as materialidades da cultura digital com base no custo energético e ambiental presente no processo de produção, funcionamento e descarte dos aparatos tecnológicos que compõem essa cultura. Para tanto, nos fundamentamos em pesquisas bibliográficas e análises de dados estatísticos. Concluímos que a atual fase da cultura digital é tributária de uma constante exploração da natureza, um aspecto que se contrapõe ao imaginário da imaterialidade tradicionalmente atrelado aos estudos da cibercultura.
Consideration of technological and safety aspects of using zinc oxide nanoparticles for intensifying whey fermentation
Authors: Kochubei-Lytvynenko Oksana , Bilyk Olena , Vysotskyi Oleksandr , Zabroda Artem
Published: September 2024

The study is dedicated to using zinc oxide nanoparticles (ZnO) to intensify the fermentation of whey, an important resource in the food industry. Traditional methods of whey fermentation take a lot of time and require significant resources, reducing their economic efficiency. This study found that the addition of ZnO nanoparticles significantly accelerates the fermentation process. Treating whey with the electro-spark method for 60 seconds allowed achieving the necessary acidity level (160±10 °T) in 18 hours, almost twice as fast as traditional methods, which take up to 36 hours. ZnO nanoparticles also improve the activity of lactic acid bacteria and increase the bactericidal ability of macrophages, which contributes to the overall efficiency of the fermentation process.
The use of ZnO nanoparticles in whey production can significantly improve the efficiency of the technological process, reducing fermentation time and improving the quality of the final product. This opens up new prospects for medium and small enterprises looking to improve the economic efficiency of their operations.
In addition to accelerating fermentation, ZnO nanoparticles have additional advantages in terms of product safety and quality. The study showed that ZnO nanoparticles enhance the antioxidant properties of fermented products, which is important for maintaining their freshness and nutritional value. The high reactivity of ZnO nanoparticles allows them to interact with bacterial membrane receptors, increasing their metabolic activity and resistance to external factors.
Thus, the study demonstrates the significant potential of using ZnO nanoparticles to intensify the whey fermentation process, contributing to more efficient production of food products and ensuring their high quality. This is especially important in modern conditions of limited resources and growing demands for economic efficiency and food safety. The introduction of ZnO nanoparticles into production processes can be a key step in improving fermentation technologies and increasing the competitiveness of food products in the market.
Study of antioxidant properties of organic dried black mulberry
Authors: Tkachenko Alina
Published: September 2024

The object of the study is black dried organic mulberry. The subject of research is the antioxidant properties of black dried organic mulberry. The research hypothesis is that due to its antioxidant properties, organic black mulberry can serve as a source for the production of food additives to slow down oxidation processes in fat-containing products.
The study investigated changes in the quality of the fat base for the production of flour confectionery products: butter with sesame oil in a ratio of 80:20 %. Black dried inorganic mulberry was used as a control sample. This made it possible to compare the inhibitory-stabilizing effect on lipids of organic and inorganic raw materials. On the 10th day of storage of the samples, the peroxide number in the fat with the addition of organic mulberry was 1.7 times lower than in the fat base without the addition of stabilizers. The peroxide number in the fat with organic mulberry added was 17.5 ½O mmol/kg. Primary oxidation in the sample with inorganic mulberry also occurred more slowly than in the sample without any additives. On the 10th day of storage, the amount of peroxides was 1.2 times less than the amount of peroxides in the fat base without the addition of mulberry. The fat acid value of black organic dried mulberry added on day 10 was 1.21 mn/KOH, with black inorganic dried mulberry added 1.80 mg/KOH. The sample without added antioxidants had an acid value of 2.12 mg/KOH. The content of ascorbic acid in black dried inorganic and organic mulberries does not differ significantly and is 10.78 and 10.49 mg/100 g, respectively. It has been proven that the content of polyphenolic compounds is 18.2 and 27.2 mg/100 g, respectively, in dried inorganic and organic black mulberries. It is their presence that explains the antioxidant properties of mulberry. Therefore, organic production affects the accumulation of polyphenolic compounds in plants. Polyphenolic compounds have antimicrobial properties, so their higher amount in organic raw materials is dictated by the fact that organic plants must independently fight against microbiological pests without the use of pesticides. Further research will be devoted to the creation of nutritional supplements based on organic black mulberry.
Identification of the role of intellectual property in the startup projects management system
Authors: Orlova Kateryna
Published: September 2024

The object of the research in the paper is intellectual property as one of the key resources of startup projects. The research is aimed at providing the understanding of intellectual property role in ensuring the efficiency of startup projects management and overcoming its undervaluing. Current conditions of Ukrainian enterprises functioning demand the search of effective tools for forming competitive advantages and ensuring the recovery of economy, that emphasizes the necessity of innovation activity activation. The study focused on startup projects as one of the forms of activation of innovation activity. The author proposed the definition of a startup as a temporary structure (organized in the form of a business entity and/or project), which has innovative characteristics of the business model, generates an innovative product and is aimed at significant growth and scaling. Startup projects have their peculiarities which influence the respective management system. On the basis of the conducted research the directions of startup projects management were identified, one of which is the management of startup project resources. Intellectual property, in its turn, is one of the key resources of startup projects considering the innovative nature of their business models. Efficient management of the intellectual property objects is capable of forming significant advantages for the startup project, which will result in its performance indicators. The main directions of intellectual property management in startup projects include development of intellectual property, market analysis, protection of intellectual property rights, commercialization of intellectual property rights. Ensuring the efficiency of the intellectual property management provides for the observance of relevant principles, the main of which include the principles of systematicity, reasonableness, efficiency, alternativeness, ensuring development, adaptability, social responsibility. The obtained research results will contribute to increasing the awareness of startup founders regarding the role and peculiarities of management of intellectual property.
The graph theoretic formulation of the team formation problem based on the factor of competition
Authors: Riabenko Anton , Tereschenko Elina , Bakurova Anna , Pyrozhok Andrii , Kuzkin Olexiy
Published: September 2024

The object of the research is to increase the level of productivity of teamwork due to the effective selection of participants who demonstrate the highest level of productivity in cooperation. The presented research is aimed at the mathematical formalization of the problem of team formation based on the results of a series of competitions using graph-theoretic approaches. Each competition in this series involves teams with the same number of participants. The composition of the team necessarily changes for each subsequent competition. After the competitive series, the obtained information about the teams' composition and their results is evaluated for the success of the interaction of the participants, which can be used in the formation of successful teams. A graph-theoretic formalization of the team formation problem on a complete undirected weighted graph has been developed. The set of vertices of this graph corresponds to the set of potential participants. Each edge is weighted with a number that reflects the quality of the interaction between the two participants. A valid solution is to cover the graph with cliques, the size of which is determined by the number of team members. A mathematical model of a two-criterion problem with MAXSUM and MAXMIN criteria was built, where the first criterion evaluates the overall success of the created teams, the second criterion evaluates the «weakest link», allowing to choose the option that maximizes the minimum edge weights for each clique. A two-criterion objective function defines a Pareto set consisting of all Pareto optima in the set of admissible solutions. The algorithmic problem of finding the complete set of alternatives, which is a subset of the Pareto set of minimum power when the condition of equality of the objective functions for the complete set of alternatives and the Pareto set is fulfilled, is considered. The weight of the edges of the graph is calculated using the scores obtained during the series of competitions. In practice, the research results can be used as a basis for the development of team building techniques.
Study of technological aspects of manufacture of polymer composite material by centrifugal fiber forming method
Authors: Lisovyi Vadym , Bessarabov Volodymyr
Published: September 2024

The object of the study is the technological aspects of manufacturing the hesperidin polymer composite material by the method of centrifugal fiber formation. This method is considered the basis of a relatively new and cost-effective way of producing solid dispersion systems. Using the centrifugal molding method, it is possible to obtain highly soluble forms of active pharmaceutical ingredients in the form of fibers of various sizes using a wide range of polymeric materials with high speed and low cost due to simple equipment. Due to the innovative design of the centrifugal fiber formation method, it was chosen for the development of solid dispersion systems of the bioflavonoid hesperidin, which has a wide range of different pharmacological properties, but low bioavailability.
Solid dispersed systems of hesperidin by the method of centrifugal fiber formation were produced on the basis of a pharmaceutically acceptable polymeric carrier of polyvinylpyrrolidone and mannitol. For the obtained solid dispersed systems, such basic pharmaco-technological characteristics as loss in mass during drying, bulk volume, bulk volume after shrinkage, bulk density, bulk density after shrinkage, compressibility index, Gaussner coefficient were determined.
Comprehensive tests of the stability of the studied samples of the solid dispersion system of hesperidin were carried out under the conditions of accelerated tests for 6 months. According to the obtained results, it was established that the developed polymer composite material is stable in the studied conditions, and its conditional shelf life is 2 years.
A technological scheme for the production of the hesperidin polymer composite material in the form of solid dispersed systems by the method of centrifugal fiber formation has been developed. In particular, the technological process is described step by step and the critical indicators of quality control of the obtained composite material are determined. The proposed technology can be implemented in modern chemical and pharmaceutical industries. This will contribute to the expansion of the market of highly effective socially oriented medicines.
Evaluation of the Effectiveness of Using the CFTR Modulator Ivacaftor/Lumacaftor in Children with Cystic Fibrosis in the Sverdlovsk Region (Prospective Cohort Study)
Authors: Vasenyova Yuliya O. , Vakhlova Irina V. , Averyanov Oleg Yu.
Published: September 2024

Background. A modern achievement in the treatment of cystic fibrosis has been the discovery of small molecules that restore the processes of synthesis, transport to the membrane, and the work of the defective CFTR protein. Drugs whose action is aimed at restoring the function of the CFTR protein are called CFTR modulators. The aim of the study is the conduction of a comprehensive assessment of the effectiveness of CFTR modulator ivacaftor/lumacaftor therapy in children with cystic fibrosis based on the study of clinical, laboratory, and instrumental data. Methods. CFTR modulator ivacaftor/lumacaftor was received for 12 months by 23 children of the main group aged 2–17 years, who are homozygous carriers of the F508del mutation of the CFTR gene in the absence of the L467F complex allele. A control examination of the main group was conducted at the start of the study and then every 3 months for 12 months of drug administration. Results. The condition of the patients in the observation groups at the start of the study was assessed as moderate to severe, the bronchopulmonary process was in the stage of incomplete clinical remission. In the main group, the level of aspartate aminotransferase significantly decreased, in the control, on the contrary, there was a tendency for this indicator to increase. The level of alkaline phosphatase (alkaline phosphatase) decreased and reached normal in the main group; the relative risk of hyperphosphatasemia during treatment decreased by 5 times (0.187 (0.063–0.557)). The level of gamma-glutamyltranspeptidase (gamma-GTP) and the number of patients with elevated GGTP decreased (24.65 and 19.69 IU/l, respectively; 61 and 13%). In the control group, the level of gamma-GTP increased and the alkaline phosphatase did not normalize. The indicators of forced exhalation volume in the first second and forced vital capacity of the lungs were initially lower in the main group, after 12 months the differences remained. There was a tendency to decrease the frequency of severe pancreatic insufficiency in the main group by 17.3%, and no changes in the control group. Sweat chlorides tended to decrease in the main group in the absence of reaching the standard values. Conclusion. The usage of the CFTR modulator ivacaftor/lumacaftor showed a greater clinical effect in improving the functioning of the digestive organs: a decrease in the risk of hyperphosphatasemia and a significant decrease in the number of patients with high levels of gamma-GTP were established, a stable level of liver enzyme activity was noted, and a tendency to increase the activity of pancreatic elastase was revealed. The tendency to decrease the indicators of sweat chlorides is shown. There were no changes in the indicators of respiratory function.
Pediatric Multisystem Inflammatory Syndrome in a Patient with a Coma with a Hyperosmolar Component in the Manifestation of Type 1 Diabetes Mellitus: Clinical Case
Authors: Lazareva Anastasia N. , Tikhonovich Yulia V. , Rtishchev Alexey Yu. , Vorontsova Inna G. , Rybkina Irina G. , Petryaykina Elena E.
Published: September 2024

Background. Due to the rarity of the combination of emergence diabetes mellitus type 1 (DM1), COVID-19, and multisystem inflammatory syndrome, each reported case represents valuable experience and increases the awareness of medical professionals. Clinical case description. A 7-year-old boy was admitted to the intensive care unit with a diagnosis of diabetes mellitus type 1, first identified. On day 2, ketoacidotic coma with a hyperosmolar component developed, a positive polymerase chain reaction (PCR) test for SARS-CoV-2 was obtained, and a picture of subarachnoid hemorrhage was described according to CT scans of the brain. On day 3, macrohematuria, peripheral edema, pasty complexion were noted; the clinical picture and laboratory examination data corresponded to a “cytokine storm” with the development of multiple organ failure. On day 5, tonic-clonic seizures and bloody discharge from the nasopharynx were noted. On day 6, a negative PCR test for SARS-CoV-2 was obtained, on chest X-rays there was a heterogeneous decrease in pneumatization in the basal sections on both sides, and bilateral hydrothorax. On day 9, meningeal symptoms were noted. On day 14, a repeated episode of a convulsive attack was registered, and changes in the brain according to MRI results were regarded as an inflammatory demyelinating lesion against the background of the course of multisystem inflammatory syndrome and DM or as posterior reversible encephalopathy (PRES syndrome). Against the background of the appointment of immunomodulatory, anticoagulant, antibacterial, antiviral therapy, positive dynamics was noted in the child's condition. On day 18, the patient in a stable condition of moderate severity was transferred to the Department of Pediatric Endocrinology for further treatment. After 14 days, the child was discharged from the hospital in a satisfactory condition. Conclusion. This case report may confirm the risk of developing multisystem inflammatory syndrome in children with DM1 and COVID-19, which requires an interdisciplinary approach and the appointment of therapy included in the standards of management of children with multisystem inflammatory syndrome.
New Opportunities of Dupilumab in Achieving Disease Control in Preschool Age Patients with Atopic Dermatitis: Clinical Case
Authors: Levina Julia G. , Pyzhyanova Polina A. , Kalugina Vera G. , Efendieva Kamilla E. , Vishneva Elena A. , Alekseeva Anna A. , Namazova-Baranova Leyla S.
Published: September 2024

Background. Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases in children. It manifests during the first year of life in majority of cases. Early AD manifestation is a risk factor for the development of other atopic spectrum diseases in the future. Nowadays, the ability of the dupilumab, as a genetically engineered biologic drug (GEBD), to modify the disease course, to reduce the frequency of AD persistence and the possibility of multimorbid atopic phenotype development is widely discussed. Thus, dupilumab management in young children with early onset and severe course arouses specific interest. Clinical case description. This article demonstrates the experience of effective administration of GEBD dupilumab in 4-year old patient with severe AD and comorbid food allergies. Continuous therapy for 12 weeks allowed to recover disease’s skin manifestations. No adverse events were reported. Conclusion. Long-term continuous dupilumab administration in children aged from 6 months to 5 years has proven its efficacy and acceptable safety profile. The potential disease-modifying effect of dupilumab is especially significant for young and preschool children due to the high risk atopic multimorbidity developing during this period.
Abundance, Distribution, and Habitat Suitability Prediction of the Guiana Dolphin and Common Bottlenose Dolphin in the Gulf of Urabá, Colombian Caribbean
Authors: Rosso-Londoño María Camila , de Moura Stephane P. G. , Palencia Juan David , Portocarrero-Aya Marcela , Caicedo-Herrera Dalila , Crespo Enrique , Diaz Stefanía , Sasaki Glaucia , Cattani Pâmela Emanuelly , Trujillo Fernando
Published: September 2024

Studying the abundance, distribution, and habitat use of dolphins can provide essential information for preserving marine biodiversity, managing coastal ecosystems, and enhancing our understanding of aquatic life. Herein, we investigated the abundance, distribution, and habitat use of two dolphin populations—Guiana dolphins (Sotalia guianensis) and common bottlenose dolphins (Tursiops truncatus)—in the Gulf of Urabá, Colombian Caribbean. Between 2017 and 2020, 34 non-systematic surveys were conducted across the studied region, amounting to an effort of 176.69 hours and covering 3,658.33 km, with a dolphin encounter probability rate of 8.65%. The Guiana dolphin population was estimated at 63 (95% CI = 53 to 76) individuals, whereas the common bottlenose dolphin population was estimated at 50 (95% CI = 43 to 58) individuals. The dolphins were mainly found in the central region of the Gulf, particularly around the Atrato River mouth and the east side of the estuary. Both species showed a preference for coastal areas with maximum depths of 20 m, and the Guiana dolphins showed a permanent presence in the Gulf of Urabá region. These findings indicate that the Gulf of Urabá acts as a crucial habitat and feeding ground for both Guiana and common bottlenose dolphins. Therefore, systematic monitoring programmes aiming to protect dolphin populations and their ecosystems from threats posed by coastal development, which currently endanger both species in the area, should be implemented.
Temporary Hearing Threshold Shift and Testing the Equal-Energy Hypothesis in a Harbor Porpoise (Phocoena phocoena) After Exposure to a Continuous Noise Band at 8 kHz, and a Revised TTS-Onset Function
Authors: Kastelein Ronald A. , Helder-Hoek Lean , Van Acoleyen Laura , Defillet Linde N. , Terhune John M.
Published: September 2024

Susceptibility to temporary hearing threshold shifts (TTS) in harbor porpoises (Phocoena phocoena) depends in part on the frequency of the fatiguing sound (the sound causing the shift). The TTS induced and the pattern of recovery were documented in a female porpoise after exposure for one hour to a continuous one-sixth-octave noise band centered at 8 kHz. This fatiguing sound was emitted at average received sound pressure levels (SPLs) between 126 and 144 dB re 1 µPa, resulting in average sound exposure levels (SELs) of 162 to 180 dB re 1 µPa2s. Hearing thresholds for narrow-band sweeps centered at 8, 11.3, and 16 kHz were determined before and after exposure. Control sessions were used to determine which SELs resulted in statistically significant TTS in the first four minutes after the fatiguing sound stopped (TTS1-4). At 8 kHz, the lowest SEL that resulted in significant TTS1-4 (4.4 dB) was 174 dB re 1 µPa2s; at 11.3 kHz, the lowest SEL that resulted in significant TTS1-4 (4.9 dB) was 168 dB re 1 µPa2s; and at 16 kHz, the lowest SEL that resulted in significant TTS1-4 (1.3 dB) was 174 dB re 1 µPa2s. The hearing frequency that was most affected was 11.3 kHz, half an octave above the fatiguing sound’s center frequency. The equal-energy hypothesis was tested by exposing the porpoise to the same noise band with SPLs of 137 to 153 dB re 1 µPa and exposure durations between two and 80 minutes; all seven combinations resulted in the same fatiguing SEL of 174 dB re 1 µPa2s; and for these combinations, the equal-energy hypothesis was upheld. The results add to the body of data on TTS-onset SELs that were used to generate a revised auditory weighting function and, thus, enhance regulatory protection of wild harbor porpoises that are exposed to anthropogenic noise at sea.
Situação de rua, vínculos sociais e as políticas públicas de saúde e de assistência social
Authors: Castro Hernany Gomes de , Rocha Emerson Ferreira
Published: September 2024

Resumo: O estudo caracteriza e discute padrões identificáveis de vinculação social na situação de rua, em relação às políticas públicas de saúde e assistência social. Com 1.944 trechos de entrevistas profundas classificadas mediante análise de conteúdo, identificou-se a situação de endereço como mecanismo moderador dos vínculos sociais. Infere-se que o estigma hierarquiza essa vinculação e proporciona o desenvolvimento de uma condição de subcidadania.