bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenotypic and Genotypic Characterization of Pan-Drug Resistant Klebsiella pneumoniae Isolated in Qatar
Authors: Sid Ahmed Mazen A. , Hamid Jemal M. , M. M. Hassan Ahmed , Abu Jarir Sulieman , Bashir Ibrahim Emad , Abdel Hadi Hamad
Published: January 2024

At secondary healthcare, Carbapenem-Resistant Enterobacterales (CREs) such as observed in Klebsiella pneumoniae are a global public health priority with significant clinical outcomes. In this study, we describe clinical, phenotypic, and genotypic characteristics of three pan-drug resistant (PDR) isolates that demonstrated extended resistance to conventional and novel antimicrobials. All patients had risk factors for acquisition of multidrug resistant organisms while microbiological susceptibility testing showed resistance to all conventional antimicrobials. Advanced susceptibility testing demonstrated resistance to broad agents such as ceftazidime-avibactam, ceftolozane-tazobactam, and meropenem-vaborbactam. Nevertheless, all isolates were susceptible to cefiderocol, one of the novel antimicrobials that demonstrated potent in vitro activity against resistant Gram-negative bacteria including CREs pointing towards potential therapeutic role for PDR pathogens. Expanded genomic studies revealed multiple antimicrobial resistant genes (ARGs), including blaNMD-5 and blaOXA derivative types as well as a mutated outer membrane porin protein (OmpK37).
Synthesis, Characterization, In silico and In vitro Antimicrobial Activity of Phenothiazine-3-sulphonamide Derivatives
Authors: Ayuk Eugene L. , Uchegbu Magdalene O. , Aronimo Samuel I. , Ebiem- Kenechukwu Peace I.
Published: January 2024

The numerous biological activities of phenothiazine and sulphonamide derivatives, especially their antibacterial qualities, have attracted so much interest. In this study, the synthesis and characterization of phenothiazine-3-sulphonamide derivatives and evaluation their antimicrobial activity against the following pathogenic microorganisms is reported. Two gram-positive bacteria; (Staphylococcus aureus, and Streptococcus pyogenes), two gram-negative bacteria; (Escherichia coli, and Salmonella typhi) as well as one fungus (Aspergillus fumigatus) were used while ciprofloxacin, gentamycin and ketoconazole served as standard drugs. The synthesis of the derivatives was achieved through a base catalyzed the reaction of 4-chloroaniline with 1-naphthylamine to form 1-(naphthalen-1-yl) benzene-1,4-diamine. This intermediate was then treated with sulphur and iodine to yield the phenothiazine derivative while subsequent treatment of the phenothiazine compound with sulphonyl chlorides gave the final products. The synthesized compounds were characterized via proton nuclear magnetic resonance (1HNMR), carbon-13 nuclear magnetic resonance (13C NMR) and Fourier-transform infrared (FTIR) spectroscopic techniques. The minimum inhibitory concentration (MIC) of each compound was then determined using the agar well diffusion method. To predict the binding energies and patterns of the synthesized compounds with target proteins of the above mentioned microorganisms, molecular docking simulations were run using Autodock Vina software (version 4.2). The spectra data of the compounds for FTIR, 1H NMR and 13C NMR (δ) spectral data were consistent with the assigned structures of the synthesized compounds. The binding energies (kcal/mol) for in silico antimicrobial studies were in the range -5.1 to -7.6 kcal/mol. The MIC values were in the range -3.5 to 1.0 mg/L. The results of the in vitro test revealed that the synthesized compounds exhibits promising antimicrobial activity, and showed excellent bactericidal and fungicidal activities. The results obtained showed that the synthesized compounds possess drug-like properties and are good starting materials for drug production.
Disulfiram Inhibits Opsonin-Independent Phagocytosis of In Vivo Activated Human In-Vivo Activated Macrophages and Dendritic Cells with Variable Effects on Mitochondrial Stress and Cell Death
Authors: Li Chen , Schneider Julian Maurice , Schneider E. Marion
Published: January 2024

Disulfiram (DSF), an anti-alcoholism medicine, exerts treatment effects in patients suffering from persistent Borreliosis and also exhibits anti-cancer effects by its copper chelating derivatives. Since chronic/persistent borreliosis is characterized by increased amounts of proinflammatory macrophages, this study investigated opsonin-independent phagocytosis, migration and surface marker expression of in vivo activated human monocyte-derived macrophages and dendritic cells with and without DSF treatment. Phagocytosis of non-opsonized Dynabeads® M-450 and migration of macrophages and dendritic cells were monitored using live cell analyzer Juli™ Br for 24h by imaging every 3.5 min. Results were analyzed by a newly developed software based on the differential phase contrast images of cells before and after ingestion of Dynabeads bearing an electron dense iron core. As a control, phagocytosis was also monitored by visual counting of ingested beads. DSF decreased the phagocytic capacities exhibited by global macrophages and dendritic cells. DSF also impaired the migration of human monocyte-derived macrophages and dendritic cells (hMDMD) and significantly reduced the expression densities of surface antigens CD45 and CD14. In cells consisting of anti-inflammatory M2 macrophages, DSF led to a remarkable cell death and also increased oxidative stress as determined by MitoSox staining. Mitochondrial oxidative stress was a prominent feature in M2 macrophages which were more sensitive to DSF-induced cytotoxicity.
Integration of Railway Bridge Structural Health Monitoring into the Internet of Things with a Digital Twin: A Case Study
Authors: Armijo Alberto , Zamora-Sánchez Diego
Published: January 2024

Structural health monitoring (SHM) is critical for ensuring the safety of infrastructures like bridges. This article presents a digital twin solution for SHM of railway bridges using low-cost wireless accelerometers and Machine Learning (ML). The system architecture combines edge on-premises computing and cloud analytics to enable efficient real-time monitoring and complete storage of relevant time-history datasets. After train crossings, accelerometers stream raw vibration data, which is processed in the frequency domain and analyzed via machine learning to detect anomalies indicating potential structural issues. The digital twin approach is demonstrated on an in-service railway bridge, where vibration data was collected over two years under normal operating conditions. By learning allowable ranges for vibration patterns, the digital twin model identifies abnormal spectral peaks, suggesting changes in structural integrity. The long-term pilot proves that this affordable SHM system can provide automated and real-time warning of bridge damage and also supports the use of in-house designed sensors of lower-cost and edge computing capabilities than those used in the demonstration. The successful on-premises-cloud hybrid implementation provides a cost effective and scalable model for expanding monitoring to thousands of railway bridges, democratizing SHM to improve safety by avoiding catastrophic failures.
CM-YOLOv8: Lightweight YOLO for Coal Mine Fully Mechanized Mining Face
Authors: Fan Yingbo , Mao Shanjun , Li Mei , Wu Zheng , Kang Jitong
Published: January 2024

With the continuous development of deep learning, the application of object detection based on deep neural network in the coal mine has been expanding. Simultaneously, as the production applications demand higher recognition accuracy, most research chooses to enlarge the depth and parameters of the network to improve accuracy. However, due to the limited computing resources in the coal mining face, it is challenging to meet the computation demands of a large number of hardware resources. Therefore, this paper proposes a lightweight object detection algorithm designed specifically for coal mining face, referred to as CM-YOLOv8. The algorithm introduces adaptive predefined anchor boxes tailored to the coal mining face dataset to enhance the detection performance of various targets. Simultaneously, a pruning method based on the L1 norm is designed, significantly compressing the model's computation and parameter volume without compromising accuracy. The proposed algorithm is validated on the coal mining dataset DsLMF+, achieving a compression rate of 40% on the model volume with less than a 1% drop in accuracy. Comparative analysis with other existing algorithms demonstrates its efficiency and practicality in coal mining scenarios. The experiments confirm that CM-YOLOv8 significantly reduces the model's computational requirements and volume while maintaining high accuracy.
Analisis tingkat risiko bencana tanah longsor di wilayah Kabupaten Blitar, Jawa Timur
Authors: Desderius Kevie , Arrinjani Muhammad Said Badizzaman , Sa’adia Zahra Fadhilatus , Lie Farhan Riandhana
Published: January 2024

Indonesia merupakan negara rawan bencana apabila dilihat dari aspek geografis, klimatologis, maupun demografisnya. Letak geografis Indonesia yang berada di antara 2 benua dan 2 samudera menyebabkan potensi bencana meningkat terutama secara geologis. Letak Indonesia pada 3 lempeng, yaitu Lempeng Eurasia, Lempeng Indo-Australia, dan Lempeng Pasifik berkontribusi pada kerawanan bencana tersebut. Kabupaten Blitar dengan proporsi wilayah dataran tinggi yang besar membuat wilayah tersebut menjadi rawan terhadap potensi bencana longsor. Penelitian ini akan membahas mengenai kajian tingkat risiko bencana tanah longsor di wilayah Kabupaten Blitar melalui analisis kerentanan bencana, kapasitas bencana, dan bahaya yang dipadukan melalui teknik overlay menjadi tingkat risiko bencana tanah longsor. Hasil penelitian menunjukkan bahwa Kabupaten Blitar didominasi oleh area dengan tingkat kerawanan bencana tinggi hingga sangat tinggi. Penelitian ini diharapkan membantu upaya mitigasi pengurangan dampak bencana tanah longsor di Kabupaten Blitar.
Strategi pembangunan kawasan Perdesaan Margomarem, Kecamatan Garung, Kabupaten Wonosobo
Authors: Nastiti Dyah Meutia , Masrurun Zam Zam
Published: January 2024

Pembangunan kawasan perdesaan merupakan pembangunan integratif antar desa yang dilaksanakan dalam upaya mempercepat dan meningkatkan kualitas pelayanan, pembangunan, dan pemberdayaan masyarakat desa melalui pendekatan pembangunan yang partisipatif. Penelitian ini bertujuan untuk mengidentifikasi strategi pengembangan kawasan Perdesaan Margomarem yang terdiri dari Desa Maron, Desa Tlogo, Desa Menjer, Desa Larangan Lor dan Desa Mlandi. Pengumpulan data dilakukan dengan metode observasi, pengumpulan data sekunder, diskusi kelompok terbatas, dan wawancara mendalam. Metode analisis data menggunakan analisis menghasilkan empat belas strategi berdasarkan empat pendekatan strategi pengembangan. Saran yang diusulkan berupa inisiatif kegiatan (quick win) sebagai penentu prioritas dari banyaknya strategi pengembangan yang dihasilkan, yakni a) Penetapan kawasan perdesaan Margomarem, b) Penyusunan rencana pembangunan kawasan perdesaan Margomarem c) Pembentukan dan pelaksanaan kerja sama antar desa, d) Pelatihan dan pengembangan kapasitas kelembagaan serta studi banding, e) Penyelesaian, penanganan dan penanggulangan permasalahan perdesaan.
Analisis kinerja jalan pada Kawasan Pasar Lama di Jalan Kisamaun, Kota Tangerang
Authors: Jingga Manisa Edelin , Miladan Nur , S. Pujantiyo Bambang
Published: January 2024

Jalan Kisamaun adalah pintu masuk menuju Kawasan Pasar Lama, Kota Tangerang yang merupakan kawasan komersial. Hal ini menjadikan Jalan Kisamaun memiliki volume lalu lintas yang tinggi dan menyebabkan penurunan tingkat pelayanan jalan sehingga munculnya kemacetan lalu lintas. Perhitungan kinerja jalan dalam menampung arus lalu lintas kendaraan menjadi hal yang penting untuk diidentifikasi dan menjadi dasar intervensi lanjutan. Metode analisis kinerja jalan menggunakan analisis kuantitatif dengan indikator yaitu arus kendaraan (Q), kapasitas jalan (C), derajat kejenuhan (Dj), dan tingkat pelayanan jalan (Level of Service). Metode pengumpulan data dilakukan dengan observasi lapangan pada jam-jam puncak. Kawasan penelitian memiliki nilai arus lalu lintas mencapai 1243,6 smp/jam. Sementara, nilai kapasitas jalan mencapai 2414 skr/jam dan nilai derajat kejenuhan mencapai 0,88. Temuan ini menunjukkan kinerjra jalan pada kelas E dengan kecepatan kendaraan kadang terhenti sehingga menyebabkan antrian panjang. Kemampuan kinerja jalan pada Jalan Kisamaun tidak sesuai dengan kebutuhan kinerja untuk pengembangan kawasan komersial. Turunnya kemampuan kinerja jalan menyebabkan adanya penumpukkan kendaraan pada jam puncak sehingga terjadinya kemacetan lalu lintas pada Kawasan Pasar Lama, Jalan Kisamaun, Kota Tangerang.
Faktor prioritas kesiapan penanganan kawasan permukiman kumuh (studi kasus: bantaran Sungai Kali Anyar, Kota Surakarta)
Authors: Mahayati Parithustha , Astuti Winny , Yudana Galing
Published: January 2024

Permukiman kumuh kawasan bantaran Kali Anyar merupakan kawasan permukiman kumuh terbesar kedua di Kota Surakarta yang ditetapkan dalam SK Walikota Tahun 2016. Pendirian bangunan ilegal, kurang memadainya infrastruktur pendukung permukiman, dan kondisi sosial ekonomi masyarakat yang rendah adalah sejumlah permasalahan yang ditemui di kawasan tersebut. Langkah penanganan seperti pemugaran hingga relokasi telah diambil oleh pemerintah Kota Surakarta, namun kawasan kumuh tetap belum dapat tertangani. Terhambatnya penanganan mengisyaratkan bahwa terdapat beberapa faktor belum diprioritaskan dalam penanganan kumuh sehingga penanganan kumuh tidak merata. Penelitian ini berfokus untuk mengetahui faktor prioritas kesiapan kawasan untuk memulai penanganan permukiman kumuh di Kawasan Bantaran Kali Anyar. Penelitian ini menggunakan metode kuantitatif dengan teknik analisis AHP (Analytic Hierarchy Process) yang dilengkapi analisis deskriptif pada masing-masing faktor kesiapan. Temuan menunjukkan tujuh faktor prioritas yaitu: (1) alokasi anggaran pemerintah, (2) bentuk koordinasi antar institusi, (3) keterlibatan masyarakat dalam penanganan, (4) ketersediaan dokumen perencanaan penanganan, (5) peraturan pemerintah daerah, (6) bantuan dana swasta, dan (7) struktur kelembagaan yang berperan. Walaupun regulasi secara jelas mengatur prioritas penanganan permukiman kumuh bantaran Kali Anyar, fakta di lapangan menunjukkan beberapa faktor kesiapan penanganan kumuh masih terhambat. Hal ini menyebabkan ketidakpastian penentuan upaya penanganan kumuh bantaran Kali Anyar. Oleh karena itu, diperlukan adanya inisiasi serius pemerintah dalam merencanakan upaya pelaksanaan penanganan kumuh di bantaran Kali Anyar secara komprehensif dan terintegasi.
Kesesuaian koridor sumbu filosofis Kota Yogyakarta bagian utara terhadap komponen fisik urban tourism
Authors: Rizki Farhan , Pamardhi-Utomo Rizon , Rahayu Murtanti Jani
Published: January 2024

Kota Yogyakarta termasuk dalam Kawasan Strategis Pariwisata Nasional menjadikannya salah satu destinasi utama di Indonesia dengan beragam produk wisata salah satunya adanya aktivitas urban tourism pada ruang perkotaan. Fenomena urban tourism terlihat di koridor Jalan Margoutomo, Jalan Malioboro, dan Jalan Margomulyo yang keberadaannya yang memiliki karakter kuat sebagai koridor wisata serta sumbu filosofis bagian utara Kota Yogyakarta. Koridor ini memiliki perbedaan pada aktivitas pariwisatanya yang cenderung pasif pada Jalan Margoutomo apabila disandingkan dengan koridor Jalan Malioboro dan Jalan Margamulyo yang terlihat ramai oleh wisatawan. Signifikansi perkembangan urban tourism di Kota Yogyakarta berimplikasi pada urgensi pemenuhan komponen fisik wisata yang adaptif di lingkungan perkotaan. Artikel ini berusaha mengetahui kesesuaian koridor perkotaan Kota Yogyakarta bagian utara terhadap komponen fisik urban tourism. Penelitian ini menggunakan pendekatan deduktif dengan jenis penelitian deskriptif kuantitatif yang diaplikasikan pada tiga variabel, yaitu keberadaan daya tarik urban tourism, keterjangkauan fasilitas pendukung, dan ketersediaan aksesibilitas penunjang urban tourism. Berdasarkan hasil skoring kesesuaian menggunakan metode pembobotan variabel weighted product menunjukan bahwa koridor perkotaan Kota Yogyakarta bagian utara menghasilkan presentase 89, 33% pada Jalan Margoutomo, 100 % pada Jalan Malioboro, dan 86 % pada Jalan Margomulyo. Berdasarkan hasil analisis tersebut menunjukan bahwa ketiga koridor mempunyai kesesuaian yang sangat tinggi dalam perannya sebagai destinasi urban tourism.
Kesesuaian rencana pola ruang terhadap risiko bencana tanah longsor di Kabupaten Boyolali
Authors: Aji Abyan Bayu , Miladan Nur , Pujantiyo Bambang S
Published: January 2024

Kabupaten Boyolali merupakan wilayah yang memiliki dataran rendah, perbukitan dan pegunungan yang dekat dengan Gunung Merapi dan Gunung Merbabu. Hal ini menjadikan Kabupaten Boyolali memiliki potensi risiko rawan bencana khususnya bencana tanah longsor. Fakta menunjukkan tidak adanya integrasi dalam perencanaan wilayah di Kabupaten Boyolali dengan kajian risiko bencana khususnya tanah longsor. Dengan adanya kondisi tersebut, penelitian ini mengkaji risiko bencana tanah longsor dan melihat kesesuaian antara kajian risiko bencana tanah longsor tersebut terhadap rencana pola ruang di Kabupaten Boyolali. Penelitian ini menggunakan pendekatan deduktif dengan metode kuantitatif yang didukung analisis skoring pembobotan serta spatial overlay. Hasil penelitian menunjukkan Kabupaten Boyolali memiliki tiga tingkatan risiko bencana. Risiko bencana tanah longsor didominasi risiko rendah dan risiko tinggi berada pada bagian barat Kabupaten Boyolali dengan pola semakin dekat dengan Gunung Merapi dan Merbabu, semakin tinggi juga risiko bencana tanah longsor. Kesesuaian rencana pola ruang terhadap risiko bencana tanah longsor memiliki persentase dominan sesuai pada kawasan risiko bencana rendah dan sesuai bersyarat pada kawasan budidaya berupa lahan terbangun, pertanian dan perkebunan. Sementara, ketidaksesuaian terdapat pada wilayah dengan risiko bencana tinggi dengan rencana pola ruang berupa kawasan permukiman dan pertanian. Penelitian ini juga mengungkap bahwa pembangunan pada rencana tata ruang menunjukkan ada kecenderungan pada kawasan risiko tinggi tanah longsor.
Analisis ketersediaan sarana dan prasarana perumahan MBR di Kota Palembang
Authors: Agustian Endy , Haidir Hala , Al Kholiq Alim Anugrah
Published: January 2024

Maraknya pembangunan perumahan permukiman yang kurang selaras dengan penyediaan sarana dan prasarana bagi masyarakat khususnya untuk perumahan MBR yang menjadi salah satu isu di Kota Palembang yang dapat mempengaruhi wajah kota. Kota Palembang merupakan ibu kota Provinsi Sumatera Selatan yang di dalam dokumen RTRW Kota Palembang 2012-2023 menunjukkan bahwa daerah pinggiran Kota Palembang diarahkan untuk pembangunan perumahan, namun terdapat isu kurangnya penyediaan sarana dan prasarana dasar pada perumahan MBR tersebut. Tujuan dari penelitian ini adalah untuk menganalisis tingkat kesesuaian penyediaan prasarana dan sarana perumahan MBR di Kota Palembang. Metode yang digunakan pada penelitian ini adalah mix method perbandingan antara kondisi eksisting dengan Peraturan Pemerintah Nomor 14 Tahun 2016 tentang Penyelenggaraan Perumahan dan Kawasan Permukiman. Teknik pengumpulan data dilakukan melalui observasi, kuisioner, wawancara, dan dokumentasi. Dari analisis yang sudah dilakukan pada Perumahan Griya Asri, Perumahan Villa Bayani, Perumahan Griya Revari Indah, dan Perumahan Grand Wijaya Persada yang berlokasi di Kota Palembang tersebut, didapati bahwa tingkat kesesuaian sarana dan prasarana sudah sesuai dan terlayani, baik pada perumahan-perumahan dengan tahun pembangunan yang terbilang baru seperti perumahan Villa Bayani dan perumahan yang cukup lama seperti Perumahan Griya Asri.
Transportation Demand Omotenashi at Ijen Corridor: The problems and development strategies
Authors: Agustin Imma Widyawati , Hariyani Septiana , Nurrizkyta Ditha
Published: January 2024

Ijen was one of the roads in Malang City with land use intensity dominated by education and trade and services, generating land use caused a large movement. The main purpose of the study was to identify some problems and propose solutions to improve the performance of Ijen corridor. The meaning of “Omotenashi” is  Japanese-style excellent service mindset consisting of hospitality aspect, familiarity and warmth aspects. The study employed Customer Satisfaction Index (CSI) and Analytical Hierarchy Process (AHP). Analysis of the familiarity aspect was descriptive evaluative interaction of public transport passengers. The analysis of the warmth aspect was descriptive evaluative in physical, social and historical attractiveness. The results showed that hospitality level at Ijen Corridor was 2.038 (hospitable), the familiarity aspect was 61 out of 100 people have interacted on the public transport, while the warmth aspect showed that many buildings are physical attractions and historical areas. The Ijen Corridor's alternative development strategies include raising public awareness of the use of public transportation, restricting access to motorized vehicles, law enforcement, and improving bicycle infrastructure, as well as enhancing the quality of public transportation services, pedestrian facilities, parking management, and carpooling/sharing.
Plan de negocio para la venta de alimentos para perros por vía online en Lima moderna
Authors:   , Pinedo Anton Markus Joel , Quispe Caccha Zoyla Arelhy , Reyes Margarin Diego Alexander
Published: January 2024

El presente trabajo, sobre la venta online de alimentos para perros, la pandemia de Covid-19 ha llevado a comprar productos en línea y ya tenemos un usuario con una comprensión del comercio electrónico, por lo que decidimos iniciar el negocio virtualmente y por consiguiente se decidió evaluar la viabilidad de un negocio con una tienda física con el objetivo de cubrir las necesidades específicas de los clientes. Por tal motivo se realiza la implementación de nuestra empresa de nombre “CUATRO PATITAS”, cuyo objetivo principal es proporcionar productos satisfactorios a la vez orientar y acompañar y que estos sean de buena calidad para los engreídos de los hogares, el proyecto de negocio está dirigido principalmente a toda Lima Moderna, por medio de una página de internet y por las redes sociales se daremos a conocer sobre los productos y servicios que ofreceremos. Para instalar y comenzar las actividades del proyecto, así como los procesos internos relacionado a las compras de los productos que se comercializaran para ello identificamos los recursos necesarios. Asimismo, se realizó un estudio económico y financiero de la propuesta empresarial para que de esta manera confirmemos su viabilidad y el resultado se pronosticó con una inversión total de S/ 50,197.40, del mismo modo un VANE de S/ 11,153.00 y un VANF de S/13,418. Por último, dado que se ha sentado que existe un aumento significado en la demanda de alimentos, accesorios y artículos para mascotas, se puede deducir de las indicaciones financieras que el proyecto puede realizarse con éxito.
Estilo de vida y nivel de estrés laboral en el personal de salud de una clínica privada, Miraflores, Lima 2022
Authors:   , Ramírez Hurtado Annida Cris , Tueros Yaranga Gisela
Published: January 2024

Objetivo: Determinar la relación entre el estilo de vida y nivel de estrés laboral en el personal de salud de una clínica privada, Miraflores, Lima_2022. Material y Método: Esta investigación es aplicada y de enfoque cuantitativo, nivel correlacional, diseño no experimental y corte transversal. El tamaño de la muestra fue 66 participantes entre 14 licenciadas en enfermería, 7 médicos y 45 técnicos de enfermería. Se aplico el cuestionario del perfil de estilo de vida (PEPS-II) de Nola Pender adaptado por Bautista(2017) y la escala de estrés laboral OIT-OMS adaptado por Suarez (2013). Para la correlación de variables se utilizó la prueba de Fisher, con significancia estadística <0.05. Resultados: El personal de salud presentó una edad media de 31,7 años, prevalencia del sexo femenino (92,4%), estado civil solteros (71,2%), ocupación técnicos de enfermería (68,2%),laboran principalmente en hospitalización (56,1%), contratados (89,4%), ganan menos de 2000 soles (83,3%), cuenta con dos trabajos (50%), tiempo de labor en la institución menos de 2 años (81,8%). En cuanto al estrés laboral encontrado fue nivel medio (81,8%) y estilo de vida no saludable(97%).Conclusiones: Existe relación entre las variables el estilo de vida y el estrés laboral en el personal de salud que labora en la clínica privada de Miraflores Lima, al haberse demostrado mediante la prueba exacta de Fisher en el que se obtuvo el valor del p= 0,031.
Gestión de procesos BPM y productividad en el área de compras y subcontratos de una empresa hidroeléctrica, distrito de San Isidro (Lima-Perú), 2021
Authors:   , Izquierdo Correa Luis Martín
Published: January 2024

El propósito de la presente investigación fue determinar la influencia de la gestión de procesos BPM en la productividad del Área de Compras y Subcontratos de una empresa hidroeléctrica, distrito de San Isidro (Lima-Perú), 2021. El enfoque fue cuantitativo, con un alcance explicativo bajo el diseño no experimental transeccional correlacional causal, se utilizó una muestra censal ya que la población fue pequeña con un número de 15 colaboradores, para ello se trabajó con todos los individuos como muestra. Con respecto al coeficiente alfa de Cronbach se obtuvo un resultado para la variable gestión de procesos BPM de 0.812 y para la variable productividad de 0.701, para el contraste de hipótesis, se empleó una prueba no paramétrica conocida como la regresión curvilínea; con una significancia equivalente a 0.000<0.05; lo cual evidencia la existencia de la causalidad entre las variables de estudio, aceptando la hipótesis alterna. Por consiguiente, se afirma que la gestión de procesos BPM sí influye de manera directa y significativa (también moderada) en la productividad del Área de Compras y Subcontratos de una empresa hidroeléctrica, distrito de San Isidro (Lima-Perú), 2021.
Asociación entre síntomas depresivos y sedentarismo en adultos mayores del Centro Médico Naval
Authors:   , Paredes Alpaca Marcia Alejandra , Villalta Diaz Camila
Published: January 2024

Introducción: Para el año 2050 se espera que la población adulto mayor se duplique alcanzando un 22%. La depresión es una de las patologías más frecuentes en la población adulta mayor, la cual está fuertemente asociada al sedentarismo. Objetivo: Determinar la relación entre síntomas depresivos y actividad física en veteranos adultos mayores de la armada naval peruana y familiares. Métodos: Estudio observacional, analítico, retrospectivo. Se analizó una base de datos del estudio “Prevalence and factors associated with frailty among Peruvian older adults” realizado en consultorios externos del servicio de geriatría de un hospital militar peruano. Se incluyeron 1896 adultos mayores de 60 años a más. Se definió la variable síntomas depresivos con la obtención de un puntaje mayor a 2 en la escala de Yesavage ultracorta y la variable sedentarismo fue medida mediante la escala de Physical Activity Scale for the Elderly (PASE) la cual define sedentarismo con un puntaje menor de 62 y 64 en mujeres y hombres respectivamente. Se realizaron regresiones de Poisson ajustadas por sexo, educación, comorbilidades, dependencia funcional, polifarmacia, autorreporte de soporte social, rendimiento físico y fuerza muscular. Resultados: Los síntomas depresivos incrementan las probabilidades de presentar sedentarismo. En el modelo ajustado por sexo en 1.17 (1.05 - 1.30), educación 0.77 (0.69-0.85), y comorbilidades 1.39 (1.15 - 1.67). Conclusión: Los síntomas depresivos incrementan la probabilidad de desarrollar sedentarismo y viceversa.
Comparación de la maduración esquelética de las vértebras cervicales utilizando tomografía computarizada volumétrica y radiografía lateral estricta en pacientes de 10 a 19 años
Authors:   , Echevarría Sánchez Joffre Gustavo
Published: January 2024

Objetivo: Las imágenes de tomografía computarizada de haz cónico (TCHC) pueden ser útiles para estimar la madurez cervical vertebral (MCV). El objetivo de este estudio fue evaluar la confiabilidad de imágenes derivadas de TCHC versus radiografías laterales (RL) para estimar la MCV en una población peruana. Materiales y métodos: La muestra evaluada consistió en 40 imágenes derivados de TCHC y 40 imágenes de RL de individuos de 10 a 19 años. Un observador entrenado y calibrado (puntuaciones Kappa ≥ 0.90) interpretó las imágenes TCHC y RL dos veces. Se analizó la confiabilidad intraobservador de cada etapa de maduración tanto en cortes sagitales de las TCHC como en las imágenes de RL utilizando las estadísticas kappa ponderadas (α = 0.05). La comparación entre cortes TCHC y las imágenes RL utilizando los estadios de maduración de las vértebras cervicales (MCV) se analizó mediante el coeficiente de correlación de rango de Spearman, p <0.05. Resultados: La prueba kappa ponderada mostró una concordancia intraobservador casi perfecta para los estadios MCV utilizando los cortes sagitales de la TCHC (0.873). Teniendo en cuenta las imágenes de RL, la prueba kappa ponderada también mostró una concordancia intraobservador casi perfecta (0.937). En ambos acuerdos intraobservador, la diferencia se limitó a una etapa de maduración del MCV. La primera y segunda concordancia intraobservador para los estadios MCV entre los cortes sagitales TCHC y las imágenes LC fue casi perfecta (0.937 y 0.874). También se encontraron valores de correlación altos en la primera (0.975) y segunda (0.976) concordancia intraobservador para los estadios MCV de los cortes sagitales TCHC e imágenes de RL. Conclusión: La TCHC es un método confiable para la evaluación de los estadios MCV y puede usarse como método alternativo para este propósito. Los ortodoncistas pueden usar las TCHC como una herramienta valiosa para la estimación del método MCV.
Metodologia Inovadora de Criação de Interlocks de Dispositivo de Resfriamento Utilizando Redes Neurais Artificiais
Authors: Zimmermann Tallita de Souza , Cunha Garcia Domingos Sávio , Araújo Leonardo Amorim , Freitas Samuel Alves , Santos Ana Paula Lima , Rosseti Gustavo José Santiago , Moreira Silvana Rodrigues Pires , Machado Lisleandra
Published: January 2024

O controle continuado de ativos físicos tem se mantido como assunto recorrente de estudos científicos e, na contemporaneidade da segunda década do Século XXI, esse controle não se limita aos ativos físicos de elevado custo situados em fábricas, como geradores eólicos, ou ainda aviões, navios ou outros recursos produtivos, mas inclui também os equipamentos médicos de última geração que cada vez mais têm o seu downtime controlado. Com os conceitos de IoT e IoMT cada vez mais presentes devido às novas tecnologias trazidas pelo 5G, o campo do controle virtual de ativos torna-se ainda mais promissor. O presente trabalho propõe uma nova ferramenta que permita a diferenciação entre estados de funcionamento de um dispositivo de resfriamento, amplamente utilizado em equipamentos médicos e nao médicos, através de algoritmos de Machine Learning. O principal desafio é traduzir a informação para a linguagem de máquina para que seja assim viabilizada uma forma de auxílio informacional de alta qualidade ao processo de tomada de decisões pelos usuários do equipamento, ou a sua automatização. As ferramentas de Virtual Engenieering atualmente em desenvolvimento, como Digital Twin, requerem modelagens complexas do funcionamento de máquinas e seus componentes, e trabalhos como este podem ajudar a desmitificar a compreensão de problemas de alta complexidade, permitindo o advento de funcionalidades digitais. A utilizacão de ferramentas de Data Science se mostra crucial para o desenvolvimento desta nova área tecnológica.
Metodologia Inovadora para Determinação do Perfil Profissional e Identificação de Desafios e do Papel de Stakeholders na Indústria 4.0.
Authors: Oliveira Elohim Jun Odo , Cunha Garcia Domingos Sávio , Araújo Leonardo Amorim , Freitas Samuel Alves , Santos Ana Paula Lima , Rosseti Gustavo José Santiago , Moreira Silvana Rodrigues Pires , Machado Lisleandra
Published: January 2024

O presente trabalho apresenta resultados de uma pesquisa cujo objetivo foi identificar o perfil do profissional dentro da Indústria 4.0 e quais seus principais desafios, além de verificar o papel dos stakeholders das organizações no contexto atual. Realizou-se um Survey de abrangência nacional com 20 gerentes, todos com no mínimo 6 meses de experiência no cargo e encarregados de no mínimo 2 funcionários nos últimos 5 anos, atuando em um conjunto pré-determinado de empresas categorizadas dentro da tipologia Indústria 4.0. Através da pesquisa de campo identificou-se, dentre outros, quais os principais empregos atualmente sendo substituídos por tecnologias contemporâneas – como a automação robotizada ou a inteligência artificial – além de outras variáveis de opinião dos gestores, sua preferências entre certificações e domínio sobre o assunto, conhecimentos sobre línguas estrangeiras, conhecimentos sobre linguagens de programação, entre outras hard skills e soft skills, relevância da escolaridade do profissional na contratação e manutenção do emprego e a preferência entre adaptabilidade e experiência. Concluindo, a presente pesquisa identifica habilidades necessárias para que o profissional se mantenha competitivo no contexto da Indústria 4.0, além de identificar programas disponibilizados pelo governo e por empresas, voltados a capacitar profissionais frente a estes desafios.
Nova Metodologia para Determinação de Padrões de Consumo, Fidelidade de Marca e Propensão a Consumir entre Usuários de um Aplicativo de Bem-Estar, utilizando Machine Learning
Authors: Lima Arthur Costa , Cunha Garcia Domingos Sávio , Araújo Leonardo Amorim , Freitas Samuel Alves , Santos Ana Paula Lima , Rosseti Gustavo José Santiago , Moreira Silvana Rodrigues Pires , Machado Lisleandra
Published: January 2024

O mercado brasileiro de aplicativos de celular voltados à saúde e bem-estar cresceu 45% entre 2019 e 2020, em grande parte devido aos novos hábitos impostos à população devido à Pandemia Covid-19, sendo que o nº de startups do setor, ou healthtechs, aumentou 16,11% apenas entre 2019 e 2022 no Brasil, demonstrando o potencial desse mercado. O objetivo principal deste artigo é apresentar uma nova metodologia para identificação de clientes com maior potencial de fidelização, a partir do banco de dados de clientes de uma startup do setor de saúde e bem-estar cujo produto é um App de celular voltado a orientar o usuário em seus treinamentos físicos em corrida de rua, ofertado com acesso gratuito nos primeiros 15 dias, apresentando baixo percentual de fidelização. Com a utilização de ferramentas de machine learning, a partir da análise do comportamento dos atletas usuários os primeiros dias de treinos, foi possível inferir o potencial de cada um se tornar assinante do serviço e continuar seu treinamento em corrida de rua com a empresa analisada, o que permitirá ao setor de marketing direcionar esforços e recursos em nichos mais prioritários. Conclui-se pela viabilidade da presente metodologia para healthtechs com perfil similar.
Metodologia Inovadora para Análise de Riscos no Cronograma de Manutenção de Aeronaves através da Simulação de Monte Carlo
Authors: Ferreira Henrique Brigato , Cunha Garcia Domingos Sávio , Araújo Leonardo Amorim , Leal Carlos Artur Alevato , Assunção Arthur Nascimento , Rosseti Gustavo José Santiago , Moreira Silvana Rodrigues Pires , Machado Lisleandra
Published: January 2024

Considerada uma das mais importantes do mundo, a indústria aeronáutica brasileira segue representando um cluster de desenvolvimento no país, tendo exportado 156 aviões e helicópteros até outubro de 2023, contabilizando US$ 2,1 bilhões em exportações. Nessa cadeia, além dos fornecedores e fabricantes, as empresas aéreas e oficinas de manutenção têm grande importância do ponto de vista tecnológico, criando soluções inovadoras para os problemas técnicos. Este artigo apresenta projeto de desenvolvimento que estudou, por meio de métodos estatísticos e computacionais, com destaque para a Simulação de Monte Carlo [SMC], a execução do cronograma de atividades de conversão de uma aeronave, para fornecer aos tomadores de decisão de uma empresa brasileira do setor aeronáutico uma estimativa em termos de dias úteis necessários para finalizar as atividades, além do risco que essa duração adotada traz ao Business Plan de entregas de aeronaves.
Comparative analysis and epidemiological study of SARS-CoV-2 in first wave among different states of India
Authors: Kaushik Rakesh , Nikita  , Lugani Yogita , Gupta Saurabh , Gururaj K. , Arya Aditya , Rishabh
Published: January 2024

Over the past few years, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has shown a global spread. While various governments and medical organizations are still attempting to control the disease's spread to overcome the global health crisis, the development of vaccines has also contributed in decelerating the spread. India has been among the top death-toll nations caused due to SARS-CoV-2. Among the global data, India was found to be the third country with the highest mortality cases of 157 thousand, and Maharashtrawas having the most higher number of mortality cases followed by Tamil Nadu and others. Retrospective study on data from 28 Indian states and 8 Union Territories (UTs) provided a detailed look at the transmission pathways and case fatality rate (CFR) of the SARS-CoV-2. The percent distribution of CFR calculated in each geographical zone of India i.e. Central, Eastern, North Eastern and Northern, Southern and Western zone was 17%, 14%, 7%, 22%, 12%, and 28%, respectively. The CFR was significantly (P<0.01) higher in period II comprising April to June of the year 2020. We calculated the CFR for every month using a standard formula and noted that the CFR varied significantly across different times of year (P<0.01). Moreover, CFR was also evaluated spatially across different geographical zones in India. We observed that western zone showed the highest CFR as compared to other zones. The epidemiology of SARS-CoV-2 was evaluated in patients of various ages and co-morbidities. Patients >21 years had the highest age-specific positivity rate. The prevalence of SARS-CoV-2 patients in acute and chronic diseases was 12.87 and 87.13 percent, respectively. Thus, this analytical epidemiological study serves specifically in establishing a relationship between SARS-CoV-2 infection and other precipitating factors causing morbidity and mortality during the given time frame in the first wave, in the year 2020 (Jan-Dec, 2020).
Eco-friendly volatile additive enabling efficient large-area organic photovoltaic module processed with non-halogenated solvent
Authors: Yang Yang , Jia Ziyan , Pan Jiannan , Chen Xu , Li Yaohui , Liu Tianyu , Zhu Hanbo , Yao Jizhong , Yan Buyi
Published: January 2024

The pursuit of sustainable manufacturing for organic solar cells (OSCs) has prompted the exploration of environmentally friendly, non-halogenated solvents. However, contemporary OSCs processed with these solvents often require the inclusion of toxic halogenated additives to optimize photovoltaic performance. In this study, we devised a processing method that incorporates not only a non-halogenated solvent but also a non-halogenated additive. The introduction of the eco-friendly menthol (MT) effectively mitigates detrimental disordered aggregation during film formation by leveraging its strong polarity to enhance acceptor crystallization, thereby optimizing the donor-acceptor morphology. These advancements ultimately lead to more efficient exciton dissociation and charge carrier transport, resulting in the realization of large-area organic photovoltaic modules (19.31 cm2) with a notable power conversion efficiency (PCE) of 15.74%. To the best of our knowledge, this PCE represents the highest reported value for large-area modules processed with non-halogenated solvents and is comparable to state-of-the-art organic photovoltaic modules processed with conventional halogenated solvents. This research underscores the significant potential of fully non-halogenated processing in achieving sustainable manufacturing for high-performance OSCs.
Compassion Versus Infection Prevention and Control in Hospital Visiting; A False Dichotomy? A Case Study of Informal Caregiving in a Ugandan Regional Referral Hospital
Authors: Ackers Louise , Ackers-Johnson Gavin , Mugahi Richard , Namiiro Rachel
Published: January 2024

This paper addresses the role of visitors or ‘attendants’ in the transmission and management of infection risk in a public referral hospital in Uganda. The study built on research on maternal sepsis which found that over 50% antibiotics administered in the hospital were for Healthcare Associated Infections (HAIs). The data was collected during the COVID-19 pandemic which introduced new risks and heightened concern about social movements within hospitals and between hospitals and communities. In the first study of its kind, observational data was collected on a 24/7 basis to capture the presence and roles of attendants in a low resource setting exposing both the infection risks associated with these forms of movement but also the absolute necessity of attendants in the management of infection risk in such contexts. The paper responds directly to a recent call for a ‘new conversation on infection prevention and compassion’ (Storr et al, 2023;408).
Cognitive and cortical alteration with full mouth rehabilitation in a group of children
Authors: Metwally Nancy Mohamed , Ragab Osama Abd Allah , Kandil Mostafa Shaaban , Elghareb Lamis Ahmed
Published: January 2024

Objectives: Individuals in pain, whether severe or mild to moderate, perform less cognitively. There are links between cognitive function and symptoms, including mental slowness, memory issues, and attentional impairment. Thus, getting thorough dental treatment could enhance mental wellness. When a child needs extensive dental work, or exhibits acute situational anxiety, whole-mouth rehabilitation under general anesthesia (GA) is one therapeutic alternative.
Aim of the work:This study looked at changes in cognition and the brain's function in children who had extensive dental rehabilitation while under general anesthesia.
Materials and methods: Thirty uncooperative, healthy male and female children, ages six to twelve, with various dental issues, were enrolled in the study. Before the treatment, one week later, and three months later, their pain was assessed using the Wong-Baker Faces Pain Rating Scale (WBFPS) as well as Face, Legs, Activity, Cry, and Consolability (FLACC). Assessments of cognitive function using the Digit Span Subtest (DS) and Electroencephalogram (EEG) were also evaluated. The data collection was statistically analyzed.
Results: All children showed a significant improvement regarding pain when evaluated by themselves or their parents after dental procedures at 1 week and 3 months later. Also, there were improvements in cognitive functions after dental procedures.
Conclusion: The research findings indicate that full mouth rehabilitation under general anaesthesia improved pain as well as cognitive and brain functions in children.
Clinical Relevance: severe dental pain in addition to the child's negative behavior interferes with routine dental visits and also with different brain and cognitive functions, so whole mouth rehabilitation under GA may be able to address these issues.
Updated single cell reference atlas for the starlet anemone Nematostella vectensis.
Authors: Cole Alison G. , Steger Julia , Hagauer Julia , Denner Andreas , Murguia Patricio Ferrer , Knabl Paul , Narayanaswamy Sanjay , Wick Brittney , Montenegro Juan D , Technau Ulrich
Published: January 2024

Background
The recent combination of genomics and single cell transcriptomics has allowed to assess a variety of non-conventional model organisms in much more depth. Single cell transcriptomes can uncover hidden cellular complexity and cell lineage relationships within organisms. The recent developmental cell atlases of the sea anemone Nematostella vectensis, a representative of the basally branching Cnidaria, has provided new insights into the development of all cell types (1,2). However, the mapping of the single cell reads still suffers from relatively poor gene annotations and a draft genome consisting of many scaffolds.
Results
Here we present a new wildtype resource of the developmental single cell atlas, by re-mapping of sequence data first published in Steger, Denner, Cole, et al 2022 (1) and Cole, Jahnel et al, 2023 (3), to the new chromosome-level genome assembly and corresponding gene models in (4). We expand the pre-existing dataset through the incorporation of additional sequence data derived from the capture and sequencing of cell suspensions from four additional samples: 24hr gastrula, 2d planula, an inter-parietal region of the bodywall from a young unsexed animal, and another adult mesentery from a mature male animal.
Conclusion
Our analyses of the full cell-state complement provide transcriptomic signatures for 127 distinct cell states, of which 47 correspond to neuroglandular subtypes. We also identify two distinct putatively immune-related transcriptomic profiles that segregate between the inner and outer cell layers. Furthermore, the new gene annotation Nv2 has markedly improved the mapping on the single cell transcriptome data and will therefore be of great value for the community and anyone using the dataset.
Effect of thymol on the efficiency of feed utilization and compensatory growth in severe feed-restricted lambs
Authors: Ahmadibonakdar Yasaman , Vakili Ali reza , Javadmanesh Ali , Rajaei-Sharifabadi Hossein
Published: January 2024

The present study aimed to evaluate the effect of thymol on growth performance and apparent total tract digestibility of nutrients in severely feed-restricted lambs. Twenty-one male Baluchi lambs were randomly blocked by live weight into three groups: control without feed restriction (CON), feed restricted (FR), and feed restricted plus thymol (FR + T). The lambs underwent a four-week feed restriction period followed by four weeks of realimentation. Thymol was administered daily to the FR + T group during the feed restriction period. Average daily gain (ADG), average daily feed intake, feed efficiency (FE), partial efficiency of maintenance (PEM), and residual feed intake (RFI) were measured as growth performance parameters. Results showed that the severe feed restriction had adverse effects on ADG and FE, but improved PEM. The effects of thymol administration on ADG, FE, PEM, and apparent total tract digestibility were not significant. However, the lambs that received thymol during feed restriction period showed a negative RFI during realimentation. Overall, these findings suggest that feed restriction as well as thymol may have the potential to improve efficiency of feed utilization in growing lambs. However, this positive effect is independent of the improvement in nutrient digestibility.