bluuebunny/crossref_metadata_2025 huggingface dataset:
On derivational and semantic aspects of the English neologisms during the COVID-19 pandemic period
Authors:   Russian presidential academy of national economy and public administration, Moscow, Nikulina Marina A.
Published: July 2022

The article is devoted to the analysis of newly-coined lexical units, which have entered the English language during the period of COVID-19 pandemic. Special attention is paid to etymological, morphological and semantic peculiarities of «denotative» neologisms which have been coined to name new phenomena (quarantine, distant work and study, vac-cination, self-isolation, restrictions, imposed on moving in space and travelling, etc.). In addition, the paper contains the analysis of reasons for an extremely wide spreading of «denotative» neologisms, related to the COVID-19 pandemic in the modern English language, as well as their active acquisition by other national languages.Besides, the article investigates the peculiarities of lexical units which may be regarded as «connotative» neolo-gisms, or emotionally colored lexemes, belonging mainly to the colloquial style and expressing the speaker`s attitude to new phenomena. The research shows that neologisms, belonging to this group, may be associated with ironical naming of the pandemic, contain the evaluation of people`s habits, their behavior in the family, at work, in public places, as well as their conduct in the Internet during the pandemic. In addition, the article offers psychological argumentation, explaining a wide occurrence of emotionally colored «coronavirus» neologisms, possessing negative connotations.
Dialogue of «war» and «peace» in Russian culture
Authors:   Russian state university for the Humanities, Kondakov Igor V.
Published: July 2022

The article is about philosophical comprehension of cultural semantics and historical dynamics of the most important concepts in Russian culture related to war and peace, which is based on the theory of dialogue as a universal cultural mechanism (M. M. Bakhtin). The extensive empirical material of Russian art and intellectual reflection (P. A. Sorokin, D. S. Likhachev, A. M. Panchenko, Y. S. Stepanov) of the 19th – 21st centuries serves as the basis for the cultural-philosophical discourse of the concepts «war» and «peace». The author describes a special algorithm of their interac-tion: entering into a dialogue with each other, the concepts converge and blur, unite and disintegrate. The key factors that condition this algorithm are the following: the initial involvement in ambivalent chronotopes; the formation of a mediative zone as a result of the dialogue (outside both chronotopes and between them); the risks of misunderstanding due to which the dialogue turns into confrontation. The article defines the conceptual sphere of «war and peace» dis-course, including both the concepts of «war» and «peace» and the emerging intermediate concepts: «peace-war», post-war, post-peace, characterized by polysemy, syncretism and semantic ambiguity. All these unconventional concepts are a kind of simulacra of historical transformations in contemporary understandings of war and peace. They are reflected in artistic texts (literature: from Leo Tolstoy to A. Korolev, music: D. Shostakovich, S. Prokofiev, cinema: from S. Gerasimov to A. Balabanov) and their critical interpretations.
The image of the cat as the Other in Russian poetry: from the 19th century classics to the « thaw» of the 20th century
Authors:   Russian state university for the humanities, Moscow, Brusilovskaya Liliya B.
Published: July 2022

The article is devoted to the culturological comprehension of the cat as a character and image of the XIX-XX century Russian poetry. It is noted that the most famous and firmly established in the Russian mentality cats enter the reading and, accordingly, the cultural experience of Russians in their childhood when they are introduced to classical Russian literature (A.S. Pushkin, the learned cat from the introduction to the poem Ruslan and Lyudmila» and the Russian liter-ary fairy tale (K. Chukovsky). The author specifies that even in the 19th century these animals were an inseparable part of the Russian literary landscape, but they did not play an important role there, being semi-animate characters of sorts for their masters (A. Fet). It is found out that some writers of the turn of XIX-XX centuries assigned supernatural abilities to them, recognizing the mysteriousness of these creatures and our inability to understand them (I. Bunin). In this historical period, Russian poets in general did not separate the cat from the animal world, which was opposed to the human world (Sasha Chyorny). The attitude towards cats changed fundamentally during the «thaw»: the poets of the Sixties saw in their behavior a degree of inner freedom and independence which they themselves were unable to achieve on the social and cultural level, but which they desired so much. (B. Akhmadulina, A. Voznesensky). The atti-tude toward animals, cats in particular, became for many a criterion of the human personal qualities and it was a sign of certain softening of mores in Soviet society (I. Brodsky). The article suggests and studies the development of the cat's image / character from a minor character being a part of the lyrical hero's environment, through positioning the cat as part of the animal world, to humanizing its image in XX century poetry and assigning to it the qualities of human beings, interlocutors and associates, on the one hand, and interpreting the cat as a creature involved in the mysteries of the Universe, on the other hand.
Bei Cun's works as a manifestation of the cultural Christianity phenomenon in contemporary China
Authors:   Amur State University, Pelevina Olga V. , Yunhao Yang ,   Amur State University
Published: July 2022

The article is devoted to the phenomenon of cultural Christianity in modern China. This phenomenon suggests the desire to explain the norms and values of Christianity to the Chinese audience through the prism of the traditional foundations of Chinese culture. Examples of cultural Christianity include Chinese intelligentsia's fascination with the history and philosophy of Christianity; Chinese masters' creating Christian images and scenes of the Virgin Mary, the Nativity, etc. in the traditional Chinese guohua style; Chinese deltiology with pictures of famous temples in Harbin; the folklore heritage of Harbin residents, etc. Sharing the idea of the existence of cultural Christianity phenomenon, the authors analyze the works of the contemporary Chinese writer Bei Cun. After 1992, when he converted to Christianity, a key transformation took place in his work. Bei Cun strives to convey to the Chinese audience the Christian categories of sin, redemption, guilt, forgiveness, love, etc. The main theme of the novel I Have a Covenant with God comes down to the Christian concept that all people are born sinful and hope for redemption, and that confession of sin and repentance are the basis for forgiveness. According to the plot, the first chapters of the novel tell us that the main character, Chen Busen, has fallen into the abyss of sin. Being abandoned by his parents, he becomes a criminal and a murderer. In the final chapters, Chen Busen's soul finds redemption through comprehension, sincere repentance, and even love for the victim's relatives. Thus, by describing the contemporary realities of Chinese society in his works, Bei Cun introduces Christian ideas and values into the Chinese picture of the world and tries to bring Christianity and Chinese culture together.
The social state in Russia: a new agenda
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Peftiev Vladimir I. , Krasnova Galina N. ,   Yaroslavl State Pedagogical University named after K.D. Ushinsky
Published: July 2022

The pandemic and recession convergence is shaping new trends and an extraordinary agenda for the social state in Russia. The recombination of social functions was also prepared by the constitutional reform of 2020, which, firstly, carried out the detailing of Article 7 of the Constitution (social state) and, secondly, it established the principles of social justice, the civilization of the state and society. The authorities responded to these challenges by developing an anti-crisis plan for the next three years (2020-2022), which is expected to break the negative trends and help achieve de-escalation of poverty, gradually adapt the Russian economy to the recession, restore growth (up to the level of 2019) and reach new frontiers of development and prosperity. As part of this strategy, the authorities help and assist: a) families with children, the unemployed and low-income people, and the creation of new jobs; b) small and medium-sized businesses; and c) systemic enterprises (tax benefits, investment, maintaining employment, etc.). The article examines the phenomenon of the social state, highlighting the most informative ideas expressed before and after the 2020 constitutional reform. The authors show diversification and intensification of the social mission of the state in Russia, the conditions for moving towards a social contract involving responsible business and active citizens (new partners). The contours of the precariat in Russia (groups in a precarious socio-economic situation) are outlined, and the need for increasing investment in human capital (medicine, education, culture, and sports) is substantiated. Social provisions and investments are needed before and after the 2021 election whatever the rate of economic growth.
Replacing Power with Flexible Structure: Implementing Flexible Deadlines to Improve Student Learning Experiences
Authors: Hills Melissa , Peacock Kim
Published: July 2022

Traditional course deadline policies uphold the myth of the “normal” student, assuming students face few and equal barriers to completing work on time. In contrast, flexible deadline policies acknowledge that students face unequal barriers and seek to mitigate them. Flexible deadline policies maintain structure while transferring some decision-making power from the instructor into the hands of the student. These practices align with current pedagogical movements in higher education that seek to empower all students to meet learning goals. This study explores student perspectives on, and use of, proactive extensions built into a recent university course. We compare extension use in low-stake, high-stake, individual, and team assignments; observe how extension use changed over the term; and examine student self-reported responses about the policy. Students unanimously agreed that the proactive extension policy was valuable to their learning. They reported that the proactive extensions enabled them to improve the quality of their work and to better manage their academic workloads, acting as self-regulated learners. They also frequently described reduced stress as a benefit. Extensions generally appeared to be used as needed rather than encouraging procrastination. Students also identified that the need to request extensions in other courses was a barrier. The instructor of this course also benefitted from implementing this policy. Faculty should consider implementing flexible deadline policies to improve student learning experiences and to contribute to a more equitable and inclusive learning environment.
Patrones léxicos compartidos en el dominio etnobiológico de las lenguas del Chaco
Authors: Brid Nicolás , List Johann-Mattis , Messineo Cristina
Published: July 2022

Con más de veinte lenguas pertenecientes a seis familias lingüísticas, el Gran Chaco despierta el interés de los lingüistas dedicados a la tipología y comparación de lenguas. No obstante, mientras que las similitudes fonológicas y gramaticales han estado en el foco de la mayoría de esos estudios, la investigación de los patrones semánticos ha tenido hasta ahora un papel menor.  Este trabajo retoma el problema de la semejanza y posible difusión de rasgos entre las lenguas del Chaco por medio de la identificación y el análisis de patrones léxico-semánticos compartidos en el vocabulario etnobiológico de dieciséis lenguas de la región. Nuestra investigación ha sido realizada con asistencia de técnicas específicas de anotación y procesamiento de datos mediante el programa EDICTOR que permite, a diferencia de los métodos clásicos, trabajar con un amplio corpus de datos disponibles de manera digital. Los resultados preliminares del análisis dan cuenta de que en el dominio estudiado los lexemas exhiben paralelismos semánticos basados en una misma motivación léxica. Dicha motivación se expresa en el plano formal mediante recursos como la derivación y la composición y, en menor medida, la polisemia, mientras que en el plano conceptual prevalecen la metáfora y la metonimia
INTEGRATED ANTENATAL CARE BY MIDWIVES IN SURABAYA
Authors: Lestari Dian , Sari Gadis Meinar
Published: July 2022

Background: The maternal mortality rate in Indonesia is still high and still far from the established target of SDG's, which is 307 maternal deaths per 100,000 live births. Adequate antenatal cares are needed to reduce maternal mortality. This study aims to determine the quality of antenatal care (ANC) services at public health centers by the framework of systems (Input, process, and output). Methods:  This study is a descriptive study with qualitative designs. Data collection was conducted in 12 health centers and the sample size is 12 midwives in the health centers. Midwives were interviewed about input, process and output components related to integrated antenatal program (ANC Terpadu 10T). In addition, it was observed also the availability of facilities, infrastructure and K1 and K4 rate related to ANC in health centers. Results: Human resources in the implementation of the integrated antenatal program by midwives at the Surabaya's Health Center still do not meet the minimum health human resources standards. Public Health Centers observed have facilities and infrastructure to support integrated antenatal care.
FACTORS OF TUBAL LIGATION USE FOR AGE LESS THAN FORTY IN URBAN AREAS OF PANGKALPINANG, BANGKA BELITUNG PROVINCE, INDONESIA
Authors: Antarini Antarini
Published: July 2022

Tubal ligation is a long-term contraceptive and relatively non-adverse, but the problem is that fecundity return surgery for couples who want to change plans to add more children cannot be guaranteed and the cost is very expensive. The research aims to analyze the factors that influence tubectomy contraception for acceptors aged less than 40 years in Pangkalpinang City in 2016. The research type was explanatory with a cross-sectional design. The sample was tubectomy contraceptive acceptors of 95 people. Data analysis was performed using a Chi-square test to determine the relationship between variables. The results showed there was no relationship between maternal education (p=0.512), husband's education (p=0.802), maternal job (p=0.522), parity (p=0.533), knowledge (p=0.484), and support from their husband (p=0.622) with tubectomy less than 40 years of age. The reasons for tubectomy that are most often cited are  related to health factors and family factors/number of children. Almost all respondents (98%) stated that they were satisfied after having a tubectomy seen from several factors including the reasons underlying the desire for tubectomy, the amount of support, the attitude, and role of the husband, support from the family, community, and role models, and easy access to costs and places to get tubectomy health services.
Asian Scientific and Cultural Forum "Dialogue with the Book"
Authors: Lizunova I. V. , Pshenichnaya E. V.
Published: July 2022

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PKCeta Promotes Stress-induced Autophagy and Senescence in Breast Cancer Cells, Presenting A Target for Therapy
Authors: Rotem-Dai Noa , Muraleedharan Amitha , Livneh Etta
Published: July 2022

The emergence of chemoresistance in neoplastic cells is one of the major obstacles in cancer therapy. Autophagy was recently reported as one of the mechanisms that promote chemoresistance in cancer cells by protecting from apoptosis and driving senescence. Thus, understanding the role of autophagy and its underlying signaling pathways is crucial for the development of new therapeutic strategies to overcome chemoresistance. We have previously reported that PKCη is a stress-induced kinase that confers resistance in breast cancer cells against chemotherapy by inducing senescence. Here we show that PKCη promotes autophagy induced by ER and oxidative stress and facilitates the transition from autophagy to senescence. We demonstrate that PKCη knockdown reduces both the autophagic flux and markers of senescence. Additionally, using autophagy inhibitors, such as chloroquine and 3-methyladenine, we show that PKCη and autophagy are required for establishing senescence in MCF-7 in response to oxidative stress. Different drugs used in the clinic are known to induce autophagy and senescence in breast cancer cells. Our study proposes PKCη as a target for therapeutic intervention, acting in synergy with autophagy-inducing drugs, to overcome resistance and enhance cell death in breast cancer.
Barreiras ao emprego de refugiados no Brasil e seus impactos na integração de longo prazo
Authors: Medeiros da Silva Pablo Marlon , Gularte Cardoso Janaína , Horn Iwaya Gabriel , de Paula Brena Samara , Pereira da Silva Arthur William , Modesto de Oliveira Wanderson Fernandes
Published: July 2022

Este artigo visa compreender como barreiras individuais, nacionais e organizacionais e suas inter-relações impactam o emprego de refugiados no mercado de trabalho brasileiro, com base na teoria da estrutura relacional da gestão da diversidade de Syed e Özbilgin (2009). Por meio de um paradigma interpretativo, abordagem qualitativa e utilizando uma pesquisa descritiva, o estudo foi realizado com oito refugiados com emprego formal na cidade de São Paulo, Brasil. As descobertas do estudo indicam a prevalência de barreiras nacionais sobre a exclusão de emprego para os refugiados, podendo potencializar fatores excludentes em níveis individual e organizacional. O governo brasileiro configurou-se como um dos principais obstáculos nacionais à integração, tendo papel particularmente importante na estrutura relacional. A pesquisa apresenta suas contribuições ao defender a condição do refugiado como inerente a uma extensão da diversidade. Ao lançar luz sobre as perspectivas dos refugiados acerca da realidade organizacional brasileira, o artigo propõe soluções que visem, por parte dos formuladores de políticas e organizações, minimizar impactos que as diferentes barreiras proporcionam à integração eficaz desses grupos nas organizações brasileiras.
Comparative hydraulic and sedimentologic study of ripple formation using experimental turbidity currents and saline currents
Authors: Koller Débora Karine , Manica Rafael , Fedele Juan Jose
Published: July 2022

Saline currents (SCs) have commonly been used to model muddy turbidity currents (TCs) in a laboratory. However, little is known about the limitations of this proxying, in particular when concerning processes and products related to their sedimentologic and stratigraphic imprints. The present study is aimed at investigating experimental hydraulic and sedimentological conditions and processes involved in the generation and development of bedforms by both SCs and TCs, when similar input conditions are applied (discharge, slope, densimetric Froude number). In all performed runs reported herein, only ripples were observed to form, and were identified and classified using known criteria such as their dimensions, near-bed shear stresses (), shear velocities (), and grain Reynolds values (Re*). Turbidity currents were observed to deposit sediments carried by the flow predominantly in the upstream section of the flume, increasing bed slope and thus increasing , , and near-bed concentrations (cb). This resulted in longer-wavelength bedforms compared to those generated by SCs under similar input conditions in those sections of the flume. On the other hand, along the downstream sections of the flume, bed slopes were observed to remain similar for all experiments, and both types of currents showed similar vertical distribution of velocities, concentrations, and stable stratification. Measured bedform wavelengths and heights were slightly higher when generated by SCs, due to the coarser bed material observed in SCs (which influenced the increase in near-bed turbulent intensities). Moreover, TCs presented a slight decrease in turbulence intensities due to their observed high near-bed suspended-sediment concentration. Spatial and temporal changes in several hydraulic parameters in both SCs and TCs highlight the role of sediment suspension in modifying turbulent processes and vertical stratification of these flows, depending on their concentrations. Both hydraulic and sedimentologic observations of this study support in principle the assumption that SCs can be used experimentally as a surrogate for diluted TCs to reproduce bedforms classified as ripples, as long as both type of currents reach similar hydraulic and sediment-transport conditions, in particular for depth-averaged concentration Cvol < 1% and near-bed concentration cb < 2%.
In response to the comment on the article “Variability in case fatality rate risk due to Covid-19 according to health services provider in Mexico City hospitals”
Authors: García-Peña Carmen , Bello-Chavolla Omar Yaxmehen , Castrejón-Perez Roberto Carlos , Jácome-Maldonado Luis David , Lozano-Juárez Luis Raymundo
Published: July 2022

Not available
Modeling Two-Phase Flow Caused by Hydrate Dissociation in a Reservoir on the Concept of Global Pressure
Authors: Deng Xuejing , Han Shuxin , Wang Haijing , Wang Zhiyuan , Li Liang , Yu Long
Published: July 2022

The classic Darcy’s two-phase flow equation has a variety of mathematically equivalent formats, such as pressure/saturation (PS), two-phase pressure (PP), and global pressure/saturation (GP). Based on the concept of global pressure, we derive a new formulation for two-phase flow caused by hydrate dissociation in porous media, coupled with the mass and energy conservation equations, thereby offering a novel theoretical frame for gas hydrate extraction simulation. The new model provides in-depth insights into complex flow fields: The dissociation of hydrates under thermal stimulation may lead to two flow fields of gas and water with different directions in the reservoir. The simulation results are in good agreement with the recorded data set of Masuda’s and Chong’s experiments, which verifies the correctness and applicability of the new model.

Based on numerical simulations of the same hydrate dissociation experiments, the efficiency of the GP method was compared with the PP method published in our previous work. The results show that the GP method has more than two times the timestep size of the PP method for unsteady flow and 1.5 times for steady flow. Furthermore, the relative residual of the GP method is even two orders of magnitude lower than that of the PP method for two-phase flows with complex variations of pressure gradient and fluid flux. Therefore, the GP method is significantly more efficient than the PP method for simulating gas hydrate development.

The proposed GP method improves the computational efficiency of hydrate extraction simulation at the laboratory scale and understanding the mechanisms of two-phase flow in reservoirs caused by hydrate dissociation. It may have potential advantages for field-scale simulation of hydrate development, which requires further studies to demonstrate.
Chromium toxicity to planktonic organisms: comparison between different routes of exposure to the metal
Authors: Vieira Bruna Horvath , Rodgher Suzelei , Haneda Renata Natsumi , Lombardi Ana Teresa , Melão Maria da Graça Gama , Espíndola Evaldo Luiz Gaeta
Published: July 2022

Given the importance of metals in the contamination of aquatic ecosystems, studies are needed to assess the effects of these contaminants on aquatic organisms through different contamination pathways. Chromium (Cr) is a metal widely used in various industrial processes, considered a priority pollutant in several countries. In the present study, ecotoxicological tests were carried out with the microalga Chlorella vulgaris, evaluating the effects of Cr on cell density, pigment concentration, and biochemical composition. Additionally, the effects of chromium exposure on cladocerans (Ceriodaphnia dubia and Ceriodaphnia silvestrii) were investigated through three contamination routes: contaminated medium, contaminated food (C. vulgaris), and the combination of both situations (contaminated medium and food). The toxicity tests with cladocerans evaluated the metal effects on survival, number of newborn produced by female, and feeding activity. The results obtained demonstrated that 48 µg L-1 total dissolved Cr reduced cell density and increased protein, carbohydrate, and lipid content in C. vulgaris. The increase in the biochemical composition of microalgae upon exposure to Cr may have contributed to the non-observation of chronic toxic effects on daphnids in the treatment with contaminated food. A decrease of 31% and 26% in the number of C. silvestrii offspring was observed for the treatment with contaminated medium (35 µg L-1 total dissolved Cr) and associated treatment (35 µg L-1 total dissolved Cr and 3 × 10-14 g Cr cells-1), respectively. The importance of the Cr poisoning pathways and the difference in cladoceran species’ sensitivity to the metal were addressed.
Intrusion Detection System Using Classification Algorithms with Feature Selection Mechanism over Real-time Data Traffic
Authors: sah Gulab , Singh Sweety , Banerjee Subhasish
Published: July 2022

The key objective of intrusion detection systems (IDS) is to protect the particular host or network by investigating and predicting the network traffic as an attack or normal. These IDS uses many methods of machine learning (ML) to learn from past-experience attack signatures and identify the new ones. Even though these methods are effective, but they have to suffer from large computational costs due to considering all the traffic features, together. Moreover, emerging technologies like the Internet of Things (IoT), Big data, etc. are getting advanced day by day, as a result, network traffics is also increasing rapidly. Therefore, the issue of computational cost needs to be addressed properly. Thus, in this research, firstly, the ML methods have been used with feature selection technique (FST) to reduce the number of features by picking out only the important ones from NSL-KDD and CICIDS2017 datasets that helped to build IDSs with lower cost but with the higher performance which would be appropriate for vast scale network. The experimental result proved that the proposed model i.e. Decision tree (DT) with Recursive feature elimination (RFE) performs better than other classifiers with RFE in terms of accuracy, specificity, precision, sensitivity, F1-score, and G-means on both datasets.
RAFT Polymerization of MMA in the Channels of Different Mesoporous Materials
Authors: Xue Tao , Wei Yan , Yu Caili , Zhang Faai , Zhou Zhongqun
Published: July 2022

Reversible addition fragmentation transfer (RAFT) polymerization is of key significance for its suitability for most monomer and well-studied reaction mechanism. Herein, a serial of mesoporous silica (MS) materials, including rod-liked and spherical SBA-15, spherical MCM-41, and MCM-48, were successfully synthesized and modified by silane coupling agent γ-aminopropyltriethoxysilane (KH550). The modified MS was utilized as a microreactor for reversible addition–fragmentation chain transfer (RAFT) polymerization of methyl methacrylate (MMA) using a xanthate as a chain transfer agent and AIBN as an initiator. Note that modified MS had lower specific surface area and pore volume while maintained the original morphological structure. Owing to the confinement effects, poly(methyl methacrylate) (PMMA) prepared from internal mesoporous channels featured with higher molecule weight and initial thermal decomposition temperature than these from conventional RAFT polymerization. More importantly, the PMMA obtained from the spherical SBA-15 and modified MCM-48 exhibited the highest molecule weight. This work provided a novel approach to design of polymer microstructure for a wider application, such as in drug release.
A Meta-synthesis of Qualitative Research on the Adaptation Experience of Elderly People Moving to the Institutionson
Authors: Zhao Di , Niu Meilan , Ma Rui , Shi Yan , Zhou Lin , Song Yuxia , Zhang Xiang , Wang Peng
Published: July 2022

Objective
The proportion of elderly people who relocated to institutions for elderly care is gradually increasing.They will face various challenges and pressures after moving to pension institutions.At present, qualitative research focuses on the life experience of the elderly in institutions. However, comprehensive qualitative research focuses on the adaptation process of the elderly after moving to pension institutions.Thus, the aim of the study to evaluate published qualitative research evidence related to the adaptation process of older people after moving to a pension institution.
Methods
We have followed the methodology of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).Computer searches of Whiley Online Library, Cochrane Library, CINHAL, Medline, EMbase, Pubmed, Web of Science, China Academic Journal Full Text Database (CNKI), China Biomedical Literature Database (CBM), Wanfang Database ( Wanfang Data) and VIP database to collect qualitative studies on the processes, experiences and feelings of elderly people moving to residential care institutions, all searched from the establishment of the database to April 1, 2022. Qualitative studies were evaluated qualitatively using JBI, and data were analysed using meta-aggregation.
Results
A total of 12 literatures were included, and three new themes were summarized. The first theme was the load stage, the second theme was the adjustment stage, and the third theme was the acceptance stage.The results are integrated into the process of relocation and adaptation of the elderly in Nursing Home.
Conclusions
This study explores and extends the existing evidence and findings, which can help caregivers in nursing home staffs to understand the stages of the process of adaptation and provide new perspectives on the nature of adaptive change and adaptive interventions by medical and nursing staff for older people in nursing facilities.
Global sensitivity analysis using multi-resolution polynomial chaos expansion for coupled Stokes-Darcy flow problems
Authors: Kroeker Ilja , Oladyshkin Sergey , Rybak Iryna
Published: July 2022

Determination of relevant model parameters is crucial for accurate mathematical modelling and efficient numerical simulation of a wide spectrum of applications in geosciences. The conventional method of choice is the global sensitivity analysis (GSA). Unfortunately, at least the classical Monte-Carlo based GSA requires a high number of model runs. Response surfaces based techniques, e.g. arbitrary Polynomial Chaos (aPC) expansion, can reduce computational effort, however, they suffer from the Gibbs phenomena and high hardware requirements for higher accuracy. We introduce GSA for arbitrary Multi-Resolution Polynomial Chaos (aMR-PC) which is a localized aPC based data-driven polynomial discretization. The aMR-PC allows to reduce the Gibbs phenomena by construction and to achieve higher accuracy by means of localization also for lower polynomial degrees. We apply these techniques to perform the sensitivity analysis for the Stokes-Darcy problem which describes fluid flow in coupled free-flow and porous-medium systems. We consider the Stokes equations in the free-flow region, Darcy's law in the porous-medium domain and the classical interface conditions across the fluid-porous interface including the conservation of mass, the balance of normal forces and the Beavers-Joseph condition for the tangential velocity. This coupled problem formulation contains four uncertain parameters: the exact location of the interface, the permeability, the Beavers-Joseph slip coefficient and the uncertainty in the boundary conditions. We carry out the sensitivity analysis of the coupled model with respect to these parameters using the Sobol indexes on the aMR-PC expansion and conduct the corresponding numerical simulations.
Deformation estimation of Soft Pneumatic Actuators under external force baesd on experimental nonlinear Euler-Bernoulli beam
Authors: Jiang Li , Lai Gen , Tang Jianhua
Published: July 2022

Soft pneumatic actuators(SPAs) can be adapted to grasp objects of different shapes, and it is helpful to estimate the SPA's deformation under external force, but their low stiffness bring signifcant challenges to the experimental characterization and modeling of their statics. Aiming at achieving the target of estimating SPA's deformation through establishing relation models between external force, air pressure, and SPA's deformation, a practical and straightforward estimation method is proposed in this paper. The nonlinear Euler-Bernoulli beam(NEBB) is applied, the SPA is simplified as a nonlinear cantilever beam, and the complex internal air pressure effect is equivalent to the external moment to analyze the SPA's deformation. The proposed nonlinear beam SPA method and finite element method(FEA) are compared with the experimental data, respectively, and the estimated deformation curves of proposed nonlinear beam SPA method agree well with the experimental results than FEA. It is shown that SPA's deformation can be estimated accurately through the proposed method. The study establishes a nonlinear beam SPA method baesd on nonlinear Euler-Bernoulli beam to estimate the SPA's deformation under external force and can potentially be used to analyze various SPAs’s mechanical property.
Analysis of Tire Wear Airstrip Particles (TWAP)
Authors: Spanheimer Vanessa , Katrakova-Krüger Danka
Published: July 2022

Every aircraft leaves tire wear particles on the ground of airports at take-off and landing. To maintain good grip properties, the pavement must be regularly cleaned up. The gathered Tire Wear Airstrip Particles (TWAP) normally get disposed by burning. As they are similar to rubber powder the question is if they might be used as a secondary raw material to keep them longer in the circular economy. In this study gathered TWAP of the runway of an airport in Germany are compared to ambient ground rubber powder from truck tire treads. Both are analyzed microscopically with regard to their morphology, particle size distribution and chemical composition by calcination with following elemental characterization of the ash by Energy-Dispersion-X-ray Analysis (EDS) in the Scanning Electron Microscope (SEM) and Thermal Gravimetric Analysis (TGA). The particle size distribution of TWAP is broader than rubber powder containing also much smaller particles. The mineral content is about 60% of the gathered TWAP. These minerals can be residues of the pavement or break wear and to a smaller amount from the rubber ingredients. Although TWAP on their own are similar to rubber powder, the impurities they contain may have an impact with regard to potential applications.
CCT3-related genetic and immune characteristics and its diagnostic and prognostic performances in lung adenocarcinoma
Authors: Huang Junfeng , Hu Bingqi , Yang Ying , Liu Huanhuan , Fan Xingyu , Zhou Jing , Chen Liwen
Published: July 2022

Background
Chaperonin-containing tailless complex polypeptide 1 (TCP1) subunit 3 (CCT3) is overexpressed in a wide range of cancers and has a connection with poor prognosis. However, its role in lung adenocarcinoma (LUAD), the most common type of non-small cell lung cancer (NSCLC) remained to be elucidated.
Methods
The Timer and UALCAN databases, Human Protein Atlas (HPA) and The Cancer Genome Atlas (TCGA) data were used to analyze CCT3 expression in LUAD. Both the Wilcoxon rank-sum test and the regression model were used to investigate the connection between clinicopathologic characteristics of LUAD patients and CCT3 expression. The diagnostic efficiency of CCT3 for LUAD was assessed by receiver operating curve, and the prognostic value of CCT3 was determined by Cox regression models, the Kaplan-Meier method and Nomogram prediction. Next, we identified the most related genes with CCT3 via GeneMANIA and String databases, and the association between CCT3 and infiltrated immune cells with single-sample Gene Set Enrichment Analysis (ssGSEA). CCT3-related infiltrating immune cells was investigated by GSEA. Finally, CCT3 roles in cell proliferation and apoptosis of LUAD A549 cells was verified by siRNA (small interfering RNA) mediated knockdown.
Results
CCT3 was upregulated in LUAD both in mRNA and protein levels. CCT3 overexpression was associated with clinicopathological characteristics including sex, smoking, T- and N-categories, pathological staging, and a poor prognosis of LUAD patients. GeneMANIA and String databases found a set of CCT3-related genes that are connected to the assembly and stability of proteins involved in proteostasis of cytoskeletal filaments, DNA repair and oncogenesis. Furthermore, CCT3 was found to be positively correlated with the infiltrating Th2 cells (r = 0.442, p < 0.01) while negatively correlated with mast cells (r = -0.49, p < 0.01) and immature dendritic cells (iDCs, r = -0.401, p < 0.001) according to ssGSEA analyzes. The pathway analysis based on GSEA method showed that the cell cycle pathway, the protein export pathway, the proteasome pathway and the ribosome pathway are enriched in CCT3 high group, whereas the JAK/STAT pathway, B cell receptor pathway, T cell receptor pathway and toll like receptor pathway were enriched in CCT3 low group. Finally, CCT3 knockdown substantially inhibited proliferation while promoted apoptosis of A549 cells.
Conclusion
Dysregulation of CCT3 in LUAD is associated with unique genetic and immune properties and has excellent diagnostic and prognostic performance for LUAD.
Effect of DFIG control parameters on small signal stability in power systems
Authors: Qi Liu , Jiahui Wu , Haiyun Wang , Hua Zhang , Jian Yang
Published: July 2022

The doubly-fed induction generator (DFIG) with virtual inertia control and reactive damping control gives a renewable energy generation system inertia and damping characteristics similar to those of a thermal power plant, and the parameters of the control strategy have a direct impact on the small-signal stability of the system. This paper firstly introduces the operating characteristics and control strategies of DFIG-based damping control and virtual inertia control, establishes a small-signal model of the control-based DFIG integrated interconnected system, and investigates the effects of virtual inertia and reactive damping values on the small-signal stability of the system; then, the maximum damping ratio of the interval oscillation mode in small disturbance analysis is taken as the optimization objective, and the control parameters are the optimization variables. An optimization method of inertia and damping parameters is established for improving the small disturbance stability of the system. The results show that the optimization procedure could improve the damping ratio of the interval oscillation mode while ensuring the system frequency. The effects of virtual inertia and reactive damping values on the small signal stability of the system are investigated, and an optimal allocation model and method for virtual inertia used to improve the small disturbance stability of the system is proposed.
The presence of soybean, but not soybean cropping frequency has influence on SOM priming in crop rotation systems
Authors: Dai Shan-Shan , He Peng , You Meng-Yang , Li Lu-Jun
Published: July 2022

Purpose: The legume crops are advocated to integrate in crop rotation systems, and legume included in cereal-based rotations have a substantial effect on improving soil fertility and health. It is not yet clear whether the frequency of legumes included in crop rotation system influences soil biochemical properties and soil organic matter (SOM) mineralization. Methods: An incubation experiment was conducted with 13C-glucose addition to evaluate the influences of the soybean (Glycine max (L.) cropping frequency on SOM mineralization under long-term wheat (Triticum aestivum L.)- and maize (Zea mays L.)-based rotation systems. PLFAs and 13C-PLFAs were measured to explore microbial biomass, community structure and microbial utilization of glucose in wheat and maize systems.Results:Glucose addition increased native SOM mineralization, i.e. positive priming effect. Compared with less soybean cropping frequency under long-term wheat- and maize-based rotation systems, Wheat-soybean-soybean-soybean rotation and maize-soybean-soybean rotation increased the total biomass (PLFAs), fungal biomass and decreased the ratio of bacteria to fungi. Furthermore, the ratio of bacteria to fungi was negatively correlated with SOM priming, indicating that greater fungal biomass played a key role in stimulating the priming effect. That the proportion of 13C-glucose in G- and fungi had a positive relationship with PE also proved the point. The presence of soybean in crop rotation increased SOM priming, while the soybean cropping frequency had no significant influence on SOM priming. However, in contrast to maize-based rotation system, the same frequency of soybean in wheat-based rotation system had fewer total PLFAs and higher B/F ratio. Conclusions:Our findings indicated that the presence of soybean increased SOM priming because of the increasing fungal biomass and the ratio of fungi to bacteria, while the soybean cropping frequency had no significant influence on SOM priming. Furthermore, the presence of soybean in maize system promoted more SOM priming than that in wheat system with glucose addition.
Cell-cell communications shape tumor microenvironment and predict clinical outcomes in clear cell renal carcinoma.
Authors: Chen Liuxun , Zeng Shen-jie , Liu Xv-dong , Tang Hai-bin , Wang Jia-wu , Jiang Qing
Published: July 2022

Background: Cell-cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless，comprehensive investigation of cell-cell communications in the ccRCC (Clear cell renal carcinoma) microenvironment and how this interplay affects prognosis still remains limited. Methods: Intercellular communications were characterized by single-cell data derived from 4 patients. And clinical prognosis and immunotherapy efficacy with different landscapes of intercellular interplay are evaluated by TCGA-KIRC and immunotherapy cohorts. Results: We employed “CellChat” package to characterize intercellular communications across all types of cells in microenvironment in VHL mutated and non-mutated samples, respectively. Afterwards, monocle analysis reveals the potential relationship of cell-cell communication molecules with immune cells (T cells, Myeloid cells) differentiation. Furthermore, Pearson correlation analysis demonstrates that these molecules also correlate with the infiltration of immune cells (T cells, Myeloid cells). A tumor cluster with highly expressed ligands was defined by quantitative analysis and transcription factor enrichment analysis, which was identified to be pivotal for intercellular communications in tumor microenvironment. Finally, bulk data indicates that different cell-cell communication clusters have significant prognosis value in ccRCC and distinguished immunotherapy efficiency. Conclusions: VHL mutant and VHL mutated renal carcinoma have different intercellular communication landscape. And intercellular communications within tumor microenvironment modulate the differentiation and infiltration of T cells and myeloid cells, and further predict clinical prognosis and immunotherapy efficacy of ccRCC.
P-glycoprotein exacerbates brain injury following experimental cerebral ischemia by promoting pro-inflammatory microglia activation
Authors: Chen Yan , Fei Xuan , Liu Ge , Li Xiang , Huang Liangliang , Yang Lele Zixin , Li Yunman , Xu Baohui , Fang Weirong
Published: July 2022

Background: Microglia are activated in the progression of ischemic stroke triggerring inflammatory response following ischemic insult. P-glycoprotein (P-gp) is an efflux transporter on microvascular endothelial cells and is elevated after cerebral ischemia. This study evaluated the effects and possible mechanisms of P-gp on microglial polarization in mice after ischemic stroke.Methods: P-gp-specific siRNA and adeno-associated virus (p-AAV) were used to silence and overexpress P-gp. Middle cerebral artery occlusion/reperfusion and oxygen-glucose deprivation/reoxygenation (OGD/R) were performed in mice and cerebral microvascular endothelial cells (bEnd.3), respectively. Co-culture of OGD/R-injured bEnd.3 cells with mouse microglial cells (BV2) was conducted in Transwell. Influences on acute ischemic stroke outcome, the expression of inflammatory cytokines, and chemokines and chemokines receptors, microglial polarization status marker, glucocorticoid receptor (GR) nuclear translocation, and GR-mediated mRNA decay (GMD) activation were evaluated via real time-polymerase chain reaction, Western blot or immunofluorescence.Results: Silencing P-gp significantly alleviated ischemia injury in association with reduced cerebral infarct size, improved neurological deficits, and attenuated expression levels of interleukin-6 and interleukin-12. Silencing P-gp mitigated pro-inflammatory microglial polarization and the expression of C-C chemokine ligand 2 (CCL2) and its receptor C-C chemokine receptor 2 expression, whereas promoted anti-inflammatory microglia polarization. Additionally, P-gp silencing also promoted GR nuclear translocation and the expression of GMD relative proteins in endothelial cells. Conversely, opposite influences were noted following overexpressing P-gp via p-AAV transfection. In contrast, silencing endothelial GR eliminated the influence of P-gp manipulation on the expressions of inflammatory cytokines and, chemokines as well as microglial polarization.Conclusions: Elevated P-gp expression aggravated inflammatory response and brain damage after ischemic stroke by augmenting pro-inflammatory microglial polarization. Mechanistically, P-gp-mediated proinflammatory microglial polarization was associated with increased endothelial CCL2 release via GMD inhibition.