bluuebunny/crossref_metadata_2025 huggingface dataset:
Socjolingwistyczne aspekty badania żywotności lektu śląskiego. Recenzja książki: Gerd Hentschel, Jolanta Tambor, István Fekete, "Das Schlesische und seine Sprecher. Etablierung in der Gesellschaft, Attitüden, Vitalität der Germanismen. / Śląski lekt i jego użytkownicy. Rozpowszechnienie, postawy społeczne wobec śląszczyzny, żywotność germanizmów w lekcie śląskim". Peter Lang, Frankfurt am Main 2022, 343 ss.
Authors: Augustyniak-Żmuda Gabriela
Published: April 2023

Sociolinguistic Aspects of Researching the Vitality of Silesian Speech. Review: Gerd Hentschel, Jolanta Tambor, István Fekete, Das Schlesische und seine Sprecher. Etablierung in der Gesellschaft, Attitüden, Vitalität der Germanismen. / Śląski lekt i jego użytkownicy. Rozpowszechnienie, postawy społeczne wobec śląszczyzny, żywotność germanizmów w lekcie śląskim, Peter Lang, Frankfurt am Main 2022, 343 pp.This article is a review of a book by G. Hentschel, J. Tambor and I. Fekete Das Schlesische und seine Sprecher. Etablierung in der Gesellschaft, Attitüden, Vitalität der Germanismen. / Śląski lekt i jego użytkownicy. Rozpowszechnie­nie, postawy społeczne wobec śląszczyzny, żywotność germanizmów w lekcie śląskim (2022). It is a German-Polish monograph which comprehensively presents research on the vitality of contemporary Silesian, based on a survey of almost 2,000 people in various age groups. The analyses were conducted using a number of quantitative and statistical methods, taking into account precisely illustrated sociolinguistic aspects (such as age, education, occupation, origin, the use of Silesian and Polish in everyday life, knowledge of German and other languages, attitude towards Silesian and Polish, identity). Socjolingwistyczne aspekty badania żywotności lektu śląskiego. Recenzja książki: Gerd Hentschel, Jolanta Tambor, István Fekete, Das Schlesische und seine Sprecher. Etablierung in der Gesellschaft, Attitüden, Vitalität der Germanismen. / Śląski lekt i jego użytkownicy. Rozpowszechnienie, postawy społeczne wobec śląszczyzny, żywotność germanizmów w lekcie śląskim, Peter Lang, Frankfurt am Main 2022, 343 ss.Artykuł Socjolingwistyczne aspekty badania żywotności lektu śląskiego jest recenzją książki G. Hentschela, J. Tambor i I. Fekete Das Schlesische und seine Sprecher. Etablierung in der Gesellschaft, Attitüden, Vitalität der Germanismen. / Śląski lekt i jego użytkownicy. Rozpowszechnienie, postawy społeczne wobec śląszczyzny, żywotność germanizmów w lekcie śląskim (2022). Jest to niemiecko­-polska monografia, która w kompleksowy sposób przedstawia badania nad żywotnością współczesnej śląszczyzny. Badania ankietowe przeprowadzono wśród prawie 2000 osób w różnych grupach wiekowych. Analizy powstały za pomocą szeregu metod ilościowych i statystycznych, przy uwzględnieniu dokładnie zobrazowanych aspektów socjolingwistycznych (takich jak wiek, wykształcenie, zawód, pochodzenie, używanie mowy śląskiej i polskiej w życiu codziennym, znajomość języka niemieckiego i innych, nastawienie wobec śląszczyzny i polszczyzny, tożsamość).
Sensitivity of Mountain Wave Drag Estimates on Separation Methods and Proposed Improvements
Authors: Procházková Zuzana , Kruse Christopher G. , Alexander M. Joan , Hoffmann Lars , Bacmeister Julio T. , Holt Laura , Wright Corwin , Sato Kaoru , Gisinger Sonja , Ern Manfred , Geldenhuys Markus , Preusse Peter , Šácha Petr
Published: April 2023

Internal gravity waves (GWs) are ubiquitous in the atmosphere, making significant contributions to the mesoscale motions. Since the majority of their spectrum is unresolved in global circulation models, their effects need to be parameterized. In recent decades GWs have been increasingly studied in high-resolution simulations, which, unlike direct observations, allow us to explore full spatiotemporal variations of the resolved wave field. In our study we analyze and refine a traditional method for GW analysis in a high-resolution simulation on a regional domain around the Drake Passage. We show that GW momentum drag estimates based on the Gaussian high-pass filter method applied to separate GW perturbations from the background are sensitive to the choice of a cutoff parameter. The impact of the cutoff parameter is higher for horizontal fluxes of horizontal momentum, which indicates higher sensitivity for horizontally propagating waves. Two modified methods, which choose the parameter value from spectral information, are proposed. The dynamically determined cutoff is mostly higher than the traditional cutoff values around 500 km, leading to larger GW fluxes and drag, and varies with time and altitude. The differences between the traditional and the modified methods are especially pronounced during events with significant drag contributions from horizontal momentum fluxes.

Significance Statement

In this study, we highlight that the analysis of gravity wave activity from high-resolution datasets is a complex task with a pronounced sensitivity to the methodology, and we propose modified versions of a classical statistical gravity wave detection method enhanced by the spectral information. Although no optimal methodology exists to date, we show that the modified methods improve the accuracy of the gravity wave activity estimates, especially when oblique propagation plays a role.
Review of Design and Control Optimization of Axial Flux PMSM in Renewable-energy Applications
Authors: Zhao Jianfei , Liu Xiaoying , Wang Shuang , Zheng Lixiao
Published: April 2023

Axial flux permanent magnet synchronous motors (AFPMSMs) have been widely used in wind-power generation, electric vehicles, aircraft, and other renewable-energy applications owing to their high power density, operating efficiency, and integrability. To facilitate comprehensive research on AFPMSM, this article reviews the developments in the research on the design and control optimization of AFPMSMs. First, the basic topologies of AFPMSMs are introduced and classified. Second, the key points of the design optimization of core and coreless AFPMSMs are summarized from the aspects of parameter design, structure design, and material optimization. Third, because efficiency improvement is an issue that needs to be addressed when AFPMSMs are applied to electric or other vehicles, the development status of efficiency-optimization control strategies is reviewed. Moreover, control strategies proposed to suppress torque ripple caused by the small inductance of disc coreless permanent magnet synchronous motors (DCPMSMs) are summarized. An overview of the rotor-synchronization control strategies for disc contra-rotating permanent magnet synchronous motors (CRPMSMs) is presented. Finally, the current difficulties and development trends revealed in this review are discussed.
Larvicidal, growth inhibitory and biochemical effects of soil bacterium, Pseudomonas sp. EN4 against Spodoptera litura (Fab.) (Lepidoptera: Noctuidae)
Authors: Sarkhandia Sunaina , Devi Meena , Sharma Geetika , Mahajan Rohit , Chadha Pooja , Saini Harvinder Singh , Kaur Sanehdeep
Published: April 2023

Background

Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) also known as tobacco caterpillar, is one of the most serious polyphagous pests that cause economic losses to a variety of commercially important agricultural crops. Over the past few years, many conventional insecticides have been used to control this pest. However, the indiscriminate use of these chemicals has led to development of insecticide resistant populations of S. litura in addition to harmful effects on environment. Due to these ill effects, the emphasis is being laid on alternative eco-friendly control measures. Microbial control is one of the important components of integrated pest management. Thus, in search for novel biocontrol agents, the current work was carried out with the aim to evaluate the insecticidal potential of soil bacteria against S. litura.

Results

Among the tested soil bacterial isolates (EN1, EN2, AA5, EN4 and R1), maximum mortality (74%) was exhibited by Pseudomonas sp. (EN4). The larval mortality rate increased in a dose-dependent manner. Bacterial infection also significantly delayed the larval development, reduced adult emergence, and induced morphological deformities in adults of S. litura. Adverse effects were also detected on various nutritional parameters. The infected larvae showed a significant decrease in relative growth and consumption rate as well as efficiency of conversion of ingested and digested food to biomass. Histopathological studies indicated damage to the midgut epithelial layer of larvae due to the consumption of bacteria treated diet. The infected larvae also showed a significantly decreased level of various digestive enzymes. Furthermore, exposure to Pseudomonas sp. also caused DNA damage in the hemocytes of S. litura larvae.

Conclusion

Adverse effects of Pseudomonas sp. EN4 on various biological parameters of S. litura indicate that this soil bacterial strain may be used as an effective biocontrol agent against insect pests.
Opioid-sparing anesthesia with dexmedetomidine provides stable hemodynamic and short hospital stay in non-intubated video-assisted thoracoscopic surgery: a propensity score matching cohort study
Authors: Ke Hui-Hsuan , Liou Jing-Yang , Teng Wei-Nung , Hsu Po-Kuei , Tsou Mei-Yung , Chang Wen-Kuei , Ting Chien-Kun
Published: April 2023

Objectives

Dexmedetomidine is an alpha-2 agonist with anti-anxiety, sedative, and analgesic effects and causes a lesser degree of respiratory depression. We hypothesized that the use of dexmedetomidine in non-intubated video-assisted thoracic surgery (VATS) may reduce opioid-related complications such as postoperative nausea and vomiting (PONV), dyspnea, constipation, dizziness, skin itching, and cause minimal respiratory depression, and stable hemodynamic status.

Methods

Patients who underwent non-intubated VATS lung wedge resection with propofol combined with dexmedetomidine (group D) or alfentanil (group O) between December 2016 and May 2022 were enrolled in this retrospective propensity score matching cohort study. Intraoperative vital signs, arterial blood gas data, perioperative results and treatment outcomes were analyzed.

Of 100 patients included in the study (group D, 50 and group O, 50 patients), group D had a significantly lower degree of decrement in the heart rate and the blood pressure than group O. Intraoperative one-lung arterial blood gas revealed lower pH and significant ETCO2. The common opioid-related side effects, including PONV, dyspnea, constipation, dizziness, and skin itching, all of which occurred more frequently in group O than in group D. Patients in group O had significantly longer postoperative hospital stay and total hospital stay than group D, which might be due to opioid-related side effects postoperatively.

Conclusions

The application of dexmedetomidine in non-intubated VATS resulted in a significant reduction in perioperative opioid-related complications and maintenance with acceptable hemodynamic performance. These clinical outcomes found in our retrospective study may enhance patient satisfaction and shorten the hospital stay.
Emergency care in post-conflict settings: a systematic literature review
Authors: Werner Kalin , Kak Mohini , Herbst Christopher H. , Lin Tracy Kuo
Published: April 2023

Background

Emergency care systems (ECS) organize and provide access to life-saving care both during transport and at health facilities. Not enough is known about ECS in uncertain contexts such as post-conflict settings. This review aims to systematically identify and summarize the published evidence on the delivery of emergency care in post-conflict settings and to guide health sector planning.

Methods

We searched five databases (PubMed MEDLINE, Web of Science, Embase, Scopus, and Cochrane) in September 2021 to identify relevant articles on ECS in post-conflict settings. Included studies (1) described a context that is post-conflict, conflict-affected, or was impacted by war or crisis; (2) examined the delivery of an emergency care system function; (3) were available in English, Spanish, or French; and (4) were published between 1 and 2000 and 9 September 2021. Data were extracted and mapped using the essential system functions identified in the World Health Organization (WHO) ECS Framework to capture findings on essential emergency care functions at the scene of injury or illness, during transport, and through to the emergency unit and early inpatient care.

Results

We identified studies that describe the unique burden of disease and challenges in delivering to the populations in these states, pointing to particular gaps in prehospital care delivery (both during scene response and during transport). Common barriers include poor infrastructure, lingering social distrust, scarce formal emergency care training, and lack of resources and supplies.

Conclusion

To our knowledge, this is the first study to systematically identify the evidence on ECS in fragile and conflict-affected settings. Aligning ECS with existing global health priorities would ensure access to these critical life-saving interventions, yet there is concern over the lack of investments in frontline emergency care. An understanding of the state of ECS in post-conflict settings is emerging, although current evidence related to best practices and interventions is extremely limited. Careful attention should be paid to addressing the common barriers and context-relevant priorities in ECS, such as strengthening prehospital care delivery, triage, and referral systems and training the health workforce in emergency care principles.
Investigating the professional capability of triage nurses in the emergency department and its determinants: a multicenter cross-sectional study in Iran
Authors: Aghabarary Maryam , Pourghaedi Zahra , Bijani Mostafa
Published: April 2023

Background

Planning to improve the professional capabilities of triage nurses requires determining the level of professional capabilities and its determinants. In this regard, the present study was conducted to determine the professional capability of triage nurses and its determinants for the first time in Iran.

Methods

A descriptive cross-sectional multicenter study was conducted in 2022. The research population included all nurses working in triage units of emergency departments of seven selected hospitals in Fars Province, south of Iran. The samples were selected using convenience sampling. The data collection tools were the “Triage nurses’ professional capability questionnaire in the emergency department” and a questionnaire to investigate determinants of triage nurses’ professional capability. Descriptive and analytical (Pearson’s correlation test and multiple linear regression analysis) were used for data analysis in the SPSS software version 27. P values ≤ 0.05 were considered significant.

Results

Out of 580 participants, 342 (59%) were female. The professional capability of triage nurses was at a moderate level with a mean score of 124.11 ± 14.72. The mean score of clinical competence, psychological empowerment, and professional commitment was 71.56 ± 9.67, 19.86 ± 3.95, and 32.69 ± 3.54, respectively. The results of multiple linear regression analysis showed that 5 factors, including participation in educational courses (p < 0.001), having clinical experience and specialized knowledge in emergency department (p < 0.001), error registry and assessment system (p < 0.001), managers’ support (p < 0.001), and recruiting experienced staff (p = 0.018) affected the nurses’ professional capability.

Conclusion

In the present study, the triage nurses had moderate levels of professional capability. It is necessary that nursing managers develop effective plans to improve the professional capability of triage nurses in emergency departments to enhance the quality and effectiveness of emergency services.
Connecting a disconnected trial network with a new trial: optimizing the estimation of a comparative effect in a network meta-analysis
Authors: McKeen Lauren , Morris Paul , Wang Chong , Morris Max D. , O’Connor Annette M.
Published: April 2023

Background

In network meta-analysis, estimation of a comparative effect can be performed for treatments that are connected either directly or indirectly. However, disconnected trial networks may arise, which poses a challenge to comparing all available treatments of interest. Several modeling approaches attempt to compare treatments from disconnected networks but not without strong assumptions and limitations. Conducting a new trial to connect a disconnected network can enable calculation of all treatment comparisons and help researchers maximize the value of the existing networks. Here, we develop an approach to finding the best connecting trial given a specific comparison of interest.

Methods

We present formulas to quantify the variation in the estimation of a particular comparative effect of interest for any possible connecting two-arm trial. We propose a procedure to identify the optimal connecting trial that minimizes this variation in effect estimation.

Results

We show that connecting two treatments indirectly might be preferred to direct connection through a new trial, by leveraging information from the existing disconnected networks. Using a real network of studies on the use of vaccines in the treatment of bovine respiratory disease (BRD), we illustrate a procedure to identify the best connecting trial and confirm our findings via simulation.

Conclusion

Researchers wishing to conduct a connecting two-arm study can use the procedure provided here to identify the best connecting trial. The choice of trial that minimizes the variance of a comparison of interest is network dependent and it is possible that connecting treatments indirectly may be preferred to direct connection.
Regression in hepatic fibrosis in elderly Chinese patients with hepatitis C receiving direct-acting antiviral treatment
Authors: Niu Bin , Zang Wenqian , Zhou Hui , Mi Yuqiang , Lu Chengzhen , Li Ping
Published: April 2023

Background

Patients infected with Hepatitis C virus (HCV) are recommended to receive treatment with direct-acting antiviral agents (DAAs), which have been certified to obtain a high sustained virological response (SVR). However, little is known about the benefits of successful anti-viral treatment to elderly patients with hepatic fibrosis. In this study, we aimed to assess degree of fibrosis in elderly patients with chronic hepatitis C (CHC) treated with DAAs, and to evaluate the correlations between identified factors associated with these changes.

Methods

This study retrospectively enrolled elderly patients with CHC who received DAAs in Tianjin Second People’s Hospital from April 2018 to April 2021. The degree of liver fibrosis was assessed using serum biomarkers and transient elastography (TE) expressed as the liver stiffness (LSM), while the hepatic steatosis was evaluated by controlled attenuated parameter (CAP). Changes in factors related to hepatic fibrosis were examined following treatment with DAAs, and associated prognostic factors were further evaluated.

Results

We included 347 CHC patients in our analysis, where 127 of these were elderly patients. For the elderly group, the median LSM was 11.6 (7.9–19.9) kPa, and this value was significantly reduced to 9.7 (6.2–16.6) kPa following DAA treatment. Similarly, GPR, FIB-4 and APRI indices were significantly reduced from 0.445 (0.275–1.022), 3.072 (2.047–5.129) and 0.833 (0.430–1.540) to 0.231 (0.155–0.412), 2.100 (1.540–3.034) and 0.336 (0.235–0.528), respectively. While in younger patients, the median LSM reduced from 8.8 (6.1–16.8) kPa to 7.2 (5.3–12.4) kPa, and the trends of GPR, FIB-4 and APRI were also consistent. The CAP in younger patients increased with statistical significance, but we did not observe any significant change in CAP for the elderly group. Based on multivariate analysis, age, LSM, and CAP before baseline were identified as determinants for LSM improvement in the elderly.

Conclusion

In this study, we found that elderly CHC patients treated with DAA had significantly lower LSM, GPR, FIB-4, and APRI values. DAA treatment did not significantly change CAP. Furthermore, we observed correlations between three noninvasive serological evaluation markers and LSM. Finally, age, LSM, and CAP were identified as independent predictors of fibrosis regression in elderly patients with CHC.
SPINK4 promotes colorectal cancer cell proliferation and inhibits ferroptosis
Authors: Hu Bang-li , Yin Yi-xin , Li Ke-zhi , Li Si-qi , Li Zhao
Published: April 2023

Background

Little is known about the role of serine peptidase inhibitor Kazal type 4 (SPINK4) in colorectal cancer (CRC) and ferroptosis. Therefore, this study aimed to determine the effect of SPINK4 on CRC pathogenesis and ferroptosis.

Methods

SPINK4 expression was analyzed in public datasets and examined using immunohistochemistry. The biological function of SPINK4 in CRC cell lines and its effect on ferroptosis were tested. An immunofluorescence assay was performed to determine the location of SPINK4 in cells, and mouse models were established to determine the effects of SPINK4 in vivo.

Results

CRC datasets and clinical samples analysis revealed that SPINK4 mRNA and protein levels were significantly reduced in CRC tissues compared to control tissues (P < 0.05). Two CRC cell lines (HCT116 and LoVo) were selected, and the in vitro and in vivo experiments showed that overexpression of SPINK4 greatly promotes the proliferation and metastasis of CRC cells and tumor growth (P < 0.05). The immunofluorescence assay indicated that SPINK4 is mainly located in the nucleoplasm and nucleus of CRC cells. Furthermore, SPINK4 expression was reduced after cell ferroptosis induced by Erastin, and overexpression of SPINK4 greatly inhibited ferroptosis in CRC cells. The results of mouse model further demonstrated that SPINK4 overexpression inhibited CRC cell ferroptosis and facilitated tumor growth.

Conclusions

SPINK4 was decreased in CRC tissues and promoted cell proliferation and metastasis; overexpression of SPINK4 inhibited CRC cell ferroptosis.
Glaucomatous optic nerve damage in the contralateral eye of a patient with peripapillary retinoschisis: a case report
Authors: Zhang Wenbo , Tian Tian , Yang Liu
Published: April 2023

Background

Peripapillary retinoschisis (PPRS) is often associated with glaucomatous eyes. It usually occurs in eyes with a more advanced stage of glaucoma with obvious optic nerve damage. We report a patient who was found to have PPRS in one eye during a routine physical examination without obvious glaucoma symptoms. Further examination revealed glaucomatous visual field loss and retinal nerve fiber layer defects in the contralateral eye.

Case presentation

A 55-year-old man presented for a routine physical examination. The anterior segment was normal in both eyes. Fundus examination revealed an elevated and red optic disc in the right eye. In addition, scattered patchy red lesions were seen on the retina on the temporal side of the optic disc. The color and boundary of the left optic disc were normal, and the cup-to-disc ratio was 0.6. Optical coherence tomography showed retinoschisis on the optic nerve head of the right eye throughout the entire circumference, extending to the retina on the temporal side of the optic disc. The intraocular pressure was 18 mmHg OD and 19 mmHg OS. The patient was diagnosed with PPRS (OD). However, no optic disc pit or optic disc coloboma was found. Further examination showed that the visual field of the patient’s right eye was generally normal, while a glaucomatous visual field defect was found in the left eye, which manifested as a nasal step visual field defect. Moreover, stereophotography and a red-free fundus image revealed two retinal nerve fiber layer defects in the supratemporal and infratemporal regions of the retina of the left eye. Continuous intraocular pressure measurement found that the intraocular pressure fluctuated between 18 and 22 mmHg OD and 19–26 mmHg OS during the daytime. Primary open-angle glaucoma was then diagnosed.

Conclusions

In this case, we found that PPRS was associated with glaucomatous optic nerve changes and visual field defects in the fellow eye.
Exercise Induced Bronchospasm and associated factors in primary school children: a cross-sectional study
Authors: Ofiaeli Ogochukwu C. , Ndukwu Chizalu I. , Ugwu Nwanneka O. , Nnamani Kenechi O. , Ebenebe Joy C. , Egbuonu Ifeoma
Published: April 2023

Background

Exercise Induced Bronchospasm(EIB) is not equivalent to asthma. As many as 20%of school aged children are estimated to have EIB. In Nigeria, there is still a dearth of information on EIB as a clinical entity.

This study determined the presence of EIB(using pre and post-exercise percentage difference in peak expiratory flow rate(PEFR) and associated factors such as age, gender, social class and nutritional status in primary school children in Nnewi, Anambra state, South-East Nigeria. The study also grouped those with EIB into those with asthma(EIBA) and those without asthma(EIBWA).

Methods

This was a community based cross-sectional study involving 6–12 year olds. The PEFR was taken at rest and after a 6 min free running test on the school play-ground using a Peak Flow Meter. A diagnosis of EIB was made if there was a decline of ≥ 10%. Those who had EIB were grouped further based on the degree of decline in post-exercise PEFR (a decline ≥ 10% < 25% → Mild EIB, ≥ 25% < 50% → Moderate EIB and ≥ 50% → Severe EIB) and then categorized as those with EIBWA/EIBA.

Results

EIB in the various minutes post-exercise was as follows: 19.2%(1stmin), 20.9%(5thmin), 18.7%(10thmin), 10%(20thmin), 0.7%(30thmin). Mild EIB accounted for the greater proportion in all minutes post-exercise and none of the pupils had severe EIB. Using values obtained in the 5thmin post-exercise for further analysis, EIBWA/EIBA = 84.1%/15.9% respectively. Mean difference in the post-exercise PEFR of EIB/no EIB and EIBWA/EIBA was -48.45(t = -7.69, p =  < 0.001) and 44.46(t = 3.77, p = 0.01) respectively.

Age and gender had a significant association to the presence of EIB and 58% of the pupils with EIB were of high social class. The BMI for age and gender z-scores of all study subjects as well as those with EIB was -0.34 ± 1.21, -0.09 ± 1.09 respectively. Other features of allergy(history of allergic rhinitis: OR–5.832, p = 0.001; physical findings suggestive of allergic dermatitis: OR–2.740, p = 0.003)were present in pupils diagnosed with EIB.

Conclusion

EIB has a high prevalence in primary school children in Nnewi and the greater proportion of those with EIB had EIBWA. EIB therefore needs to be recognized as a clinical entity and stratified properly based on the presence or absence of asthma. This will help the proper management and prognostication.
Short version of the Inventory of Parental Representations, a self-report for attachment assessment among adolescents
Authors: Lamourette Marilou , Ligier Fabienne , Guillemin Francis , Epstein Jonathan
Published: April 2023

Background

 The Inventory of Parental Representations (IPR), a self-administered questionnaire, was developed primarily to identify styles of attachment in adolescence. However, it did not present stable psychometric properties in the various American studies carried out. The aim of this study was to adapt the IPR in French and to provide a shorter version with improved psychometric properties and sound content.

Methods

The cross-cultural adaptation and content validity were carried out based on qualitative analysis by an Expert Committee and 10 non-clinical adolescents. For the quantitative analyses a cohort of 535 adolescent volunteers was enrolled, corresponding to 1070 responses, and divided into two groups: development and validation. The study of the metric properties of the adapted version of the IPR was realized in the development group, a sample of 275 responses. In case of mediocre results in the Confirmatory Factor Analysis, the development of a new and reduced IPR structure was planned using a mixed method including Classical Test Theory and Rasch Modelling in the development group. Subsequently, the study of the psychometric properties of the short, adapted version was confirmed in an independent sample of 795 responses (validation group).

Results

Out of 62 items translated, 13 needed adaptations. The analysis of their metric properties produced mediocre results. Content and psychometric property analyses generated two Short version of the IPR in the development group: a paternal scale for Fathers (Short IPRF) with 15 items and a maternal scale for Mothers (Short IPRM) with 16 items. The sound content and good psychometric properties were confirmed in the validation group (Short IPRF: Comparative Fit Index = 0.987, Tucker-Lewis Index = 0.982, Root Mean Square Error of Approximation = 0.027; Short IPRM: Comparative Fit Index = 0.953, Trucker-Lewis Index = 0.927, Root Mean Square Error of Approximation = 0.068). Using Rasch modelling, the attachment was correctly measured overall especially for insecure attachment.

Conclusions

A step-by-step process involving led to the generation of two questionnaires: a paternal scale, the Short IPRF, and a maternal scale with the Short IPRM providing opportunities to use this self-questionnaire to assess attachment among adolescents. Further work will provide a solid rating for this new tool.
Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia
Authors: Li Shan , Lu Cailian , Kang Lin , Li Qianqian , Chen Hongxu , Zhang Han , Tang Ziling , Lin Yanwen , Bai Meiyan , Xiong Peng
Published: April 2023

Background

The pathogenesis of schizophrenia is still unknown. Nearly a half of schizophrenic patients have depressive symptoms and even some impulsive behaviors. The definite diagnosis of schizophrenia is an immense challenge. Molecular biology plays an essential role in the research on the pathogenesis of schizophrenia.

Objective

This study aims to analyze the correlations of serum protein factor levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia.

Methods

Seventy drug-naïve patients with first-episode schizophrenia and sixty-nine healthy volunteers from the health check center in the same period participated in this study. In both the patient group and control group, brain-derived neurotrophic factor (BDNF), phosphatidylin-ositol-3-kinase (PI3K), protein kinase B (AKT), and cAMP-response element binding protein (CREB) levels in the peripheral blood were tested by enzyme-linked immunosorbent assay (ELISA). The depressive emotion and impulsive behaviors were evaluated with Chinese versions of the Calgary Depression Scale for Schizophrenia (CDSS) and Short UPPS-P Impulsive Behavior Scale (S-UPPS-P), respectively.

Results

The serum levels of BDNF, PI3K, and CREB in the patient group were lower than those in the control group, while AKT level, total CDSS score and total S-UPPS-P score were all higher. In the patient group, total CDSS score, and total S-UPPS-P score were both correlated negatively with BDNF, PI3K, and CREB levels but positively with AKT level, and the lack-of-premeditation (PR) sub-scale score was not significantly correlated with BDNF, PI3K, AKT, and CREB levels.

Conclusion

Our study results showed that the peripheral blood levels of BDNF, PI3K, AKT, and CREB in drug-naïve patients with first-episode schizophrenia were significantly different from those in the control group. The levels of these serum protein factors are promising biomarkers to predict schizophrenic depression and impulsive behaviors.
Reaching late adopters: factors influencing COVID-19 vaccination of Marshallese and Hispanic adults
Authors: Vincenzo Jennifer L. , Spear Marissa J. , Moore Ramey , Purvis Rachel S. , Patton Susan K. , Callaghan-Koru Jennifer , McElfish Pearl A. , Curran Geoffrey M.
Published: April 2023

Background

Marshallese and Hispanic communities in the United States have been disproportionately affected by COVID-19. Identifying strategies to reach late vaccine adopters is critical for ongoing and future vaccination efforts. We utilized a community-engaged approach that leveraged an existing community-based participatory research collaborative of an academic healthcare organization and Marshallese and Hispanic faith-based organizations (FBO) to host vaccination events.

Methods

Bilingual Marshallese and Hispanic study staff conducted informal interviews with 55 participants during the 15-minute post-vaccination observation period and formal semi-structured interviews with Marshallese (n = 5) and Hispanic (n = 4) adults post-event to assess the implementation of community vaccine events at FBOs, with a focus on factors associated with the decision to attend and be vaccinated. Formal interview transcripts were analyzed using thematic template coding categorized with the socio-ecological model (SEM). Informal interview notes were coded via rapid content analysis and used for data triangulation.

Results

Participants discussed similar factors influencing attitudes and behaviors toward receiving the COVID-19 vaccine. Themes included: (1) intrapersonal – myths and misconceptions, (2) interpersonal – protecting family and family decision-making, (3) community – trust of community location of events and influence of FBO members and leaders, (4) institutional – trust in a healthcare organization and bilingual staff, and (5) policy. Participants noted the advantages of vaccination delivery at FBOs, contributing to their decision to attend and get vaccinated.

Conclusions

The following strategies may improve vaccine-related attitudes and behaviors of Marshallese and Hispanic communities not only for the COVID-19 vaccine but also for other preventive vaccinations: 1) interpersonal-level – develop culturally-focused vaccine campaigns targeting the family units, 2) community-level – host vaccination events at convenient and/or trusted locations, such as FBOs, and engage community and/or FBO formal or lay leaders as vaccine ambassadors or champions, and 3) institutional-level – foster trust and a long-term relationship with the healthcare organization and provide bilingual staff at vaccination events. Future research would be beneficial to investigate the effects of replicating these strategies to support vaccine uptake among Marshallese and Hispanic communities.
The relationship between interpersonal violence in adulthood and mental health: a longitudinal study based on the Northern Swedish Cohort
Authors: Ziaei Shirin , Hammarström Anne
Published: April 2023

Background

Longitudinal studies evaluating the negative effects of exposure to interpersonal violence in the adulthood on the mental health of both women and men are scarce. Using longitudinal data, we evaluated the relationship between the last year experience of violence and functional somatic and depressive symptoms at the ages of 30 and 43 among participants (n = 1006; 483 women and 523 men) in the Northern Swedish Cohort. Further, the relationship between cumulative exposure to violence over a decade and mental health symptoms among participants was evaluated.

Methods

Participants’ experience of interpersonal violence and symptoms of functional somatic and depressive symptoms were evaluated with standard questionnaires at the ages of 30 and 43. General linear models were used to evaluate the relationship between the experience of interpersonal violence and mental health symptoms among the participants. The interactions between gender and violence on functional somatic and depressive symptoms were evaluated separately, and models in which the interaction was significant, were split by gender.

Results

We found that the last year experience of violence at the age of 30 was related to current functional somatic symptoms among all participants and depressive symptoms only among men, (βAdjfor the experience of any violence among men: 0.21; CI: 0.12–0.29; Vs. among women: 0.06; CI: -0.04-0.16, p for interaction = 0.02). At the age of 43, last year experience of violence was related to both functional somatic and depressive symptoms in both genders. Finally, a cumulative relationship between the experience of violence over time and mental health symptoms was observed in all participants.

Conclusions

Our findings revealed that while the relationship between the experience of interpersonal violence and mental health symptoms may differ among men and women and with age, the experience of violence can be negatively related to the mental health in both genders.
Characteristics associated with comorbid lumbar spinal stenosis symptoms in people with knee or hip osteoarthritis: an analysis of 9,136 good life with osteoArthritis in Denmark (GLA:D®) participants
Authors: Young James J. , Kongsted Alice , Jensen Rikke Krüger , Roos Ewa M. , Ammendolia Carlo , Skou Søren T. , Grønne Dorte T. , Hartvigsen Jan
Published: April 2023

Background

Previous studies have found that lumbar spinal stenosis (LSS) often co-occurs with knee or hip OA and can impact treatment response. However, it is unclear what participant characteristics may be helpful in identifying individuals with these co-occurring conditions. The aim of this cross-sectional study was to explore characteristics associated with comorbid symptoms of lumbar spinal stenosis (LSS) in people with knee or hip osteoarthritis (OA) enrolled in a primary care education and exercise program.

Methods

Sociodemographic, clinical characteristics, health status measures, and a self-report questionnaire on the presence of LSS symptoms was collected at baseline from the Good Life with osteoArthritis in Denmark primary care program for knee and hip OA. Cross-sectional associations between characteristics and the presence of comorbid LSS symptoms were assessed separately in participants with primary complaint of knee and hip OA, using domain-specific logistic models and a logistic model including all characteristics.

Results

A total of 6,541 participants with a primary complaint of knee OA and 2,595 participants with a primary complaint of hip OA were included, of which 40% and 50% reported comorbid LSS symptoms, respectively. LSS symptoms were associated with similar characteristics in knee and hip OA. Sick leave was the only sociodemographic variable consistently associated with LSS symptoms. For clinical characteristics, back pain, longer symptom duration and bilateral or comorbid knee or hip symptoms were also consistently associated. Health status measures were not consistently related to LSS symptoms.

Conclusion

Comorbid LSS symptoms in people with knee or hip OA undergoing a primary care treatment program of group-based education and exercise were common and associated with a similar set of characteristics. These characteristics may help to identify people with co-occurring LSS and knee or hip OA, which can be used to help guide clinical decision-making.
Associations between blood antioxidant levels and femoral neck strength
Authors: Niu Peng , Liu Yongxi , Zhang Yanfeng , Li Lei
Published: April 2023

Background

Studies have confirmed that antioxidants contribute to a lower risk of osteoporosis, which is an independent factor for femoral neck fracture (FNF). However, the associations between blood antioxidant levels and femoral neck strength remain unclear.

Objective

Our aim was to test the hypothesis that levels of blood antioxidants are positively associated with composite indices of bone strength in femoral neck, which integrate the bending strength index (BSI), compressive strength index (CSI), and impact strength index (ISI), in a population of middle-aged and elderly individuals.

Methods

This cross-sectional study utilized data from the Midlife in the United States (MIDUS) study. Blood levels of antioxidants were measured and analyzed.

Results

In total, data from 878 participants were analyzed. Results of Spearman correlation analyses indicated that blood levels of 6 antioxidants (total lutein, zeaxanthin, alpha-carotene, 13-cis-beta-carotene, trans-beta-carotene and total lycopene) were positively associated with CSI, BSI, or ISI in middle-aged and elderly individuals. Conversely, blood gamma-tocopherol and alpha-tocopherol levels were negatively associated with CSI, BSI, or ISI scores. Furthermore, linear regression analyses suggested that only blood zeaxanthin levels remained positively associated with CSI (odds ratio, OR 1.27; 95% CI: 0.03, 2.50; p = 0.045), BSI (OR, 0.54; 95% CI: 0.03–1.06; p = 0.037), and ISI (OR, 0.06; 95% CI: 0.00, 0.13; p = 0.045) scores in the study population after adjusting for age and sex.

Conclusions

Our results indicated that elevated blood zeaxanthin levels were significantly and positively associated with femoral neck strength (CSI, BSI, or ISI) in a population of middle-aged and elderly individuals. These findings suggest that zeaxanthin supplementation may reduce FNF risk independently.
Aspergillus terreus camptothecin-sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo
Authors: Kelany Nermeen A. , El-Sayed Ashraf S. A. , Ibrahim Manar A.
Published: April 2023

Background

Camptothecin derivatives are one of the most prescribed anticancer drugs for cancer patients, however, the availability, efficiency, and water solubility are the major challenges that halt the applicability of this drug.

Methods

Biosynthetic potency of camptothecin by Aspergillus terreus, open a new avenue for commercial camptothecin production, due to their short-life span, feasibility of controlled growth conditions, and affordability for higher growth, that fulfill the availability of the scaffold of this drug.

Results

Camptothecin (CPT) was purified from the filtrates of A. terreus, and their purity was checked by HPLC, and its chemical structure was verified by LC/MS, regarding to the authentic one. To improve the anticancer efficiency of A. terreus CPT, the drug was conjugated with sodium alginate (SA)/Titanium dioxide nanoparticles (TiO2NPs) composites, and their physicochemical properties were assessed. From the FT-IR profile, a numerous hydrogen bond interactions between TiO2 and SA chains in the SA/TiO2 nanocomposites, in addition to the spectral changes in the characteristic bands of both SA/TiO2 and CPT that confirmed their interactions. Transmission electron microscopy analysis reveals the spherical morphology of the developed SA/TiO2NPs nanocomposite, with the average particle size ~ 13.3 ± 0.35 nm. From the results of zeta potential, successful loading and binding of CPT with SA/TiO2 nanocomposites were observed.

Conclusion

The in vivo study authenticates the significant improvement of the antitumor activity of CPT upon loading in SA/TiO2 nanocomposites, with affordable stability of the green synthesized TiO2NPs with Aloe vera leaves extract.
Can antioxidant treatment replace delay in bracket bonding? An in vitro study
Authors: Zaki Shaimaa S. , Ghorab Sayed M. , Tawfik Marwa A. , Shamaa Marwa S.
Published: April 2023

Background

Deterioration in shear bond strength has been reported after immediate bracket bonding following hydrogen peroxide bleaching. This study compared the effectiveness of three antioxidant agents, namely, alpha-tocopherol, green tea extract, and sodium ascorbate, in reversing the bleaching effect and as possible alternatives to delayed bonding.

Methods

A total of 105 extracted human premolars were arbitrarily assigned to 7 groups (n = 15 each), including group 1 as the unbleached control group and six experimental groups, which were bleached with 40% hydrogen peroxide in three sessions of 15 min each. In experimental group 2, bonding was performed immediately after bleaching, whereas in groups 3 and 4, bonding was delayed for 1 and 2 weeks, respectively; meanwhile, the specimens were immersed in artificial saliva at 37 °C. Groups 5, 6, and 7 were treated immediately after bleaching with 10% of alpha-tocopherol, green tea extract, and sodium ascorbate solutions, respectively, for 15 min. Specimens were processed using 500 thermal cycles between 5 and 55 °C, with a dwell time of 30 s after 24 h of bracket bonding, and then tested for shear bond strength. The adhesive remnant index was examined to evaluate fracture mode. One-way analysis of variance, Kruskal–Wallis H, and post hoc Tukey’s honestly significant difference tests were used to compare the data. Significant results were subjected to pairwise comparisons with Bonferroni’s correction-adjusted of p values ≤ 0.050.

Results

Shear bond strength was significantly lower (p < 0.001) in the immediate bonding and 1-week delay groups than in the control group. However, no significant difference was detected among the 2-week delay, antioxidant-treated, and control groups (p > 0.05).

Conclusions

Application of 10% alpha-tocopherol, green tea extract, or sodium ascorbate for 15 min could restore shear bond strength after 40% hydrogen peroxide bleaching as an alternative to delay in bracket bonding.
Adenoid Cystic Carcinoma (ACC) of the Bartholin's gland misdiagnosed for three times: a case report
Authors: Alhashemi Moustafa , Oubari Sana , Mohamad Aya Haji , Alhashemi Mohamad , Kabel Obaida , Alhelue Afaf , Fattal Farah
Published: April 2023

Background

Adenoid cystic carcinoma (ACC) in Bartholin’s gland is an uncommon malignant tumor. These tumors have a vague clinical feature, so they are diagnosed late and discovered at a high-level stage. Our case presented Three Recurrences and Three times Misdiagnosis of Adenoid Cystic Carcinoma (ACC).

Case presentation

We report a case of adenoid cystic carcinoma arising in Bartholin's gland of a 64-year-old female patient that appeared after three previous vulvar tumors were excised. The patient underwent bilateral radiotherapy which was performed on the perineum.

Conclusion

ACC of the vulvar sweat glands is prone to misdiagnosis and delay in both diagnosis and treatment. As seen in our case, it was misdiagnosed three times as Chondroid Syringoma. Further studies need to be conducted to better understand the tumor prognosis, and its optimal treatment options.