bluuebunny/crossref_metadata_2025 huggingface dataset:
Cutting the traintracks: Cauchy, Schubert and Calabi-Yau
Authors: Cao Qu , He Song , Tang Yichao
Published: April 2023

Abstract

In this note we revisit the maximal-codimension residues, or leading singularities, of four-dimensional L-loop traintrack integrals with massive legs, both in Feynman parameter space and in momentum (twistor) space. We identify a class of “half traintracks” as the most general degenerations of traintracks with conventional (0-form) leading singularities, although the integrals themselves still have rigidity $$ \left\lfloor \frac{L-1}{2}\right\rfloor $$

L
−
1

2

due to lower-loop “full traintrack” subtopologies. As a warm-up exercise, we derive closed-form expressions for their leading singularities both via (Cauchy’s) residues in Feynman parameters, and more geometrically using the so-called Schubert problems in momentum twistor space. For L-loop full traintracks, we compute their leading singularities as integrals of (L−1)-forms, which proves that the rigidity is L−1 as expected; the form is given by an inverse square root of an irreducible polynomial quartic with respect to each variable, which characterizes an (L−1)-dim Calabi-Yau manifold (elliptic curve, K3 surface, etc.) for any L. We also briefly comment on the implications for the “symbology” of these traintrack integrals.
Electric-magnetic duality in a class of G2-compactifications of M-theory
Authors: Halverson James , Sung Benjamin , Tian Jiahua
Published: April 2023

Abstract

We study electric-magnetic duality in compactifications of M-theory on twisted connected sum (TCS) G2 manifolds via duality with F-theory. Specifically, we study the physics of the D3-branes in F-theory compactified on a Calabi-Yau fourfold Y, dual to a compactification of M-theory on a TCS G2 manifold X. $$ \mathcal{N} $$
N
= 2 supersymmetry is restored in an appropriate geometric limit. In that limit, we demonstrate that the dual of D3-branes probing seven-branes corresponds to the shrinking of certain surfaces and curves, yielding light particles that may carry both electric and magnetic charges. We provide evidence that the Minahan-Nemeschansky theories with En flavor symmetry may be realized in this way. The SL(2, ℤ) monodromy of the 3/7-brane system is dual to a Fourier-Mukai transform of the dual IIA/M-theory geometry in this limit, and we extrapolate this monodromy action to the global compactification. Away from the limit, the theory is broken to $$ \mathcal{N} $$
N
= 1 supersymmetry by a D-term.
The implicit bulk-surface filtering method for node-based shape optimization and a comparison of explicit and implicit filtering techniques
Authors: Najian Asl Reza , Bletzinger Kai-Uwe
Published: April 2023

This work studies shape filtering techniques, namely the convolution-based (explicit) and the PDE-based (implicit), and introduces the implicit bulk-surface filtering method to control the boundary smoothness and preserve the internal mesh quality simultaneously in the course of bulk (solid) shape optimization. To that end, the volumetric mesh is governed by the pseudo-solid smoothing equations, which are stiffened by the mesh-Jacobian and endowed with the Robin boundary condition, which involves the Laplace-Beltrami operator on the mesh boundaries. Its superior performance from the non-simultaneous (sequential) treatment of boundary and internal meshes is demonstrated for the shape optimization of complex solid structures. Well-established explicit filters, namely Gaussian and linear, and the Helmholtz/Sobolev-based (implicit) filter are critically examined for shell optimization in terms of consistency (rigid-body-movement production), geometric characteristics, and computational cost. It is demonstrated that implicit filtering is more numerically efficient and robustly enforces fixed boundaries compared to explicit filtering. Supported by numerical experiments, a regularized Green’s function is introduced as an equivalent explicit form of the Helmholtz/Sobolev filter. Furthermore, we give special attention to deriving mesh-independent filtered sensitivities for node-based shape optimization with non-uniform meshes. It is shown that mesh-independent filtering can be achieved by scaling discrete sensitivities with the inverse of the mesh mass matrix.
Die Bedeutung von petechialen Einblutungen im Gesichtsbereich bei der zweiten Leichenschau vor der Feuerbestattung im Einzugsbereich des Instituts für Rechtsmedizin Greifswald
Authors: Wudtke J. , Knoppik Y. , Dokter M. , Bockholdt B.
Published: April 2023

Die zweite Leichenschau vor der Feuerbestattung dient im Wesentlichen der Erkennung von nichtnatürlichen Todesfällen, die im Rahmen der ersten Leichenschau nicht als solche erkannt wurden. Immer wieder fallen dabei punktförmige Einblutungen im Gesichtsbereich, insbesondere in die Lid- und Lidbindehäute auf. Neben krankhaften und lagebedingten Ursachen können diese Einblutungen der einzige äußerlich erkennbare Hinweis auf eine stattgehabte Halskompression sein. Bei Feststellung derartiger Einblutungen im Rahmen der zweiten Leichenschau wird der Sterbefall „angehalten“ und bei der Kriminalpolizei angezeigt. Für einen 12-Jahres-Zeitraum (2010–2021) wurden retrospektiv alle angehaltenen Sterbefälle mit festgestellten Petechien analysiert. In diesem Zeitraum wurden in den Krematorien, für die das Institut für Rechtsmedizin Greifswald verantwortlich ist, insgesamt 2822 Sterbefälle angehalten. In 282 Fällen erfolgte diese Anhaltung aufgrund petechialer Einblutungen im Gesichtsbereich. Durch die zuständige Staatsanwaltschaft wurde in 47 % dieser Fälle eine gerichtliche Obduktion angeordnet. Im Beobachtungszeitraum fanden sich 2 Tötungsdelikte, die erst durch die zweite Leichenschau vor der Feuerbestattung im Krematorium festgestellt wurden. Die Untersuchung zeigt, dass petechiale Einblutungen als Anhaltspunkt für einen nichtnatürlichen Tod nicht ausreichend bei Leichenschauärzten bekannt sind.
Surgical therapy of migraine: a 12-year single-center experience
Authors: Raposio Edoardo , Raposio Giorgio
Published: April 2023

Background

In recent years, surgical therapy has taken on an increasingly decisive role in the therapeutic armamentarium of migraine. All surgical techniques are aimed at the complete neurolysis of some extra-cranial nerves, of which the most involved (in our experience) are the greater and lesser occipital, auriculotemporal, supraorbital, and supratrochlear nerves. This paper describes our surgical approaches for the treatment of occipital, temporal, and frontal trigger sites.

Methods

A single-center, retrospective study was conducted on all patients who underwent surgical treatment of migraine between 2011 and 2022. Patients were asked to fill out a headache diary and complete a migraine questionnaire assessing parameters before surgery, after 3 months, and 1 year after surgery. Data regarding age, sex, age at onset, migraines per month (in days), associated symptoms, severity (on a scale from 1 to 10), inability to work per month (in days), health status, history of neck trauma, and family history were collected. The Migraine Disability Assessment Scale (MIDAS) score was also used to evaluate the degree of disability for each patient.

Results

We have operated on 612 patients: n.266 occipital, n.248 temporal, n.98 frontal. The surgical procedure elicited a positive response in 90% of the patients (69% complete recovery). Complications were mild and temporary: mainly, hypoesthesia and numbness of the undermined areas, lasting from 3 weeks to 6 months. We observed the onset of secondary trigger sites in 257 (42%) patients.

Discussion

The described procedure is minimally invasive and highly reproducible and allows to obtain a high degree of success with a negligible rate of complications. Nevertheless, given the high percentage of occurrence of secondary trigger points, it is particularly important to warn the patient of this possibility in pre-operative visits.

Level of evidence:

Level III, Therapeutic
Effectiveness of biosimilar pegfilgrastim in patients with multiple myeloma after high-dose melphalan and autologous stem cell transplantation
Authors: Martino Massimo , Gori Mercedes , Porto Gaetana , Pellicano Maria , Santoro Ludovica , Verduci Chiara , Canale Filippo Antonio , Loteta Barbara , Moscato Tiziana , Alati Caterina , Ieracitano Maria Consuelo , Cuzzocrea Amelia , Altomonte Maria , Florenzano Maria Teresa , Morabito Antonella , Irrera Giuseppe , Naso Virginia , Pugliese Marta , Console Giuseppe , Ferreri Anna , Imbalzano Lucrezia , Tripepi Giovanni , Pitino Annalisa
Published: April 2023

Multiple myeloma (MM) is the main indication for autologous stem cell transplantation (ASCT). Novel supportive therapies (e.g., granulocyte colony-stimulating factor) have significantly improved post-ASCT-related mortality; however, data on biosimilar pegfilgrastim-bmez (BIO/PEG) in this setting is lacking. This prospective cohort study compared Italian patients with MM who received BIO/PEG post-ASCT with data collected retrospectively from historical control groups from the same center who received either filgrastim-sndz (BIO/G-CSF) or pegfilgrastim (PEG; originator). The primary endpoint was time to neutrophil engraftment (three consecutive days with an absolute neutrophil count ≥ 0.5 × 109/L). Secondary endpoints included incidence and duration of febrile neutropenia (FN). Of the 231 patients included, 73 were treated with PEG, 102 with BIO/G-CSF, and 56 with BIO/PEG. Median age was 60 years and 57.1% were male. Neutrophil engraftment was reached after a median of 10 days in the BIO/PEG and PEG groups and 11 days in the BIO/G-CSF group. Among patients who achieved neutrophil engraftment earlier than this (i.e., day 9), 58% (29/50) were on PEG; of those who achieved it later (i.e., day 11), 80.8% (59/73) were on BIO/G-CSF. FN incidence was higher with BIO/G-CSF (61.4%) versus PEG (52.1%) or BIO/PEG (37.5%) (p = 0.02 among groups). Patients on BIO/PEG had less frequent grade 2–3 diarrhea (5.5%) compared with BIO/G-CSF (22.5%) or PEG (21.9%); grade 2–3 mucositis was most frequent in the BIO/G-CSF group. In conclusion, pegfilgrastim and its biosimilar displayed an advantageous efficacy and safety profile compared with biosimilar filgrastim in patients with MM post-ASCT.
Efficacy of oblique lumbar interbody fusion versus transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases: a systematic review and meta-analysis
Authors: Li Xi-yong , Wang Yun-lu , Yang Su , Liao Chang-sheng , Li Song-feng , Han Peng-yong , Han Peng-fei
Published: April 2023

Introduction

This meta-analysis aimed to compare the differences in postoperative efficacy between oblique lumbar interbody fusion (OLIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of lumbar degenerative diseases.

Materials and methods

Strictly based on the search strategy, we searched the published papers on OLIF and TLIF for the treatment of lumbar degenerative diseases in PubMed, Embase, CINAHL, and Cochrane Library. A total of 607 related papers were retrieved, and 15 articles were finally included. The quality of the papers was evaluated according to the Cochrane systematic review methodology, and the data were extracted and meta-analyzed using Review manager 5.4 software.

Results

Through comparison, it was found that in the treatment of lumbar degenerative diseases, the OLIF group had certain advantages over the TLIF group in terms of intraoperative blood loss, hospital stay, visual analog scale (VAS) for leg pain (VAS-LP), Oswestry disability index (ODI), disc height (DH), foraminal height (FH), fused segmental lordosis (FSL), and cage height, and the differences were statistically significant. The results were similar in terms of surgery time, complications, fusion rate, VAS for back pain (VAS-BP) and various sagittal imaging indicators, and there was no significant difference.

Conclusions

OLIF and TLIF can relieve low back pain symptoms in the treatment of lumbar degenerative diseases, but OLIF has certain advantages in terms of ODI and VAS-LP. In addition, OLIF has the advantages of minor intraoperative trauma and quick postoperative recovery.
Data lake-driven analytics identify nocturnal non-dipping of heart rate as predictor of unfavorable stroke outcome at discharge
Authors: Nelde Alexander , Klammer Markus G. , Nolte Christian H. , Stengl Helena , Krämer Michael , von Rennenberg Regina , Meisel Andreas , Scheibe Franziska , Endres Matthias , Scheitz Jan F. , Meisel Christian
Published: April 2023

Background

Post-stroke heart rate (HR) and heart rate variability (HRV) changes have been proposed as outcome predictors after stroke. We used data lake-enabled continuous electrocardiograms to assess post-stroke HR and HRV, and to determine the utility of HR and HRV to improve machine learning-based predictions of stroke outcome.

Methods

In this observational cohort study, we included stroke patients admitted to two stroke units in Berlin, Germany, between October 2020 and December 2021 with final diagnosis of acute ischemic stroke or acute intracranial hemorrhage and collected continuous ECG data through data warehousing. We created circadian profiles of several continuously recorded ECG parameters including HR and HRV parameters. The pre-defined primary outcome was short-term unfavorable functional outcome after stroke indicated through modified Rankin Scale (mRS) score of > 2.

Results

We included 625 stroke patients, 287 stroke patients remained after matching for age and National Institute of Health Stroke Scale (NIHSS; mean age 74.5 years, 45.6% female, 88.9% ischemic, median NIHSS 5). Both higher HR and nocturnal non-dipping of HR were associated with unfavorable functional outcome (p < 0.01). The examined HRV parameters were not associated with the outcome of interest. Nocturnal non-dipping of HR ranked highly in feature importance of various machine learning models.

Conclusions

Our data suggest that a lack of circadian HR modulation, specifically nocturnal non-dipping, is associated with short-term unfavorable functional outcome after stroke, and that including HR into machine learning-based prediction models may lead to improved stroke outcome prediction.
Gender-specific outcomes in immune checkpoint inhibitor therapy for advanced or metastatic urothelial cancer: a systematic review and meta-analysis
Authors: Schneidewind Laila , Kiss Bernhard , Zengerling Friedemann , Borkowetz Angelika , Graf Sebastian , Kranz Jennifer , Dräger Desiree L. , Graser Annabel , Bellut Laura , Uhlig Annemarie
Published: April 2023

Purpose

To analyze gender-specific differences in survival parameters in advanced or metastatic urothelial cancer patients undergoing immune checkpoint inhibition.

Methods

The primary aim of this systematic review and meta-analysis was to evaluate gender-specific differences in disease-free (DFS), progression-free (PFS), cancer-specific survival (CSS), event-free survival (EFS), overall survival (OS) and objective response rate (ORR). The sources MEDLINE, Embase and Cochrane Library were systematically searched from January 2010 to June 2022. No restrictions were made concerning language, study region or publication type. A comparison of gender-specific differences in survival parameters was performed using a random-effects meta-analysis. A risk of bias assessment was done using the ROBINS-I tool.

Results

Five studies were included. In a random-effect meta-analysis of the studies, PCD4989g and IMvigor 211 with both using atezolizumab, females were more likely to have better objective response rate (ORR) than men (OR 2.24; 95% CI 1.20–4.16; p = 0.0110). In addition, females had a comparable median OS to men (MD 1.16; 95% CI − 3.15–5.46; p = 0.598). In summary, comparing all results, a tendency was seen toward better response rates and survival parameters in female patients. The risk of bias assessment yielded an overall low risk of bias.

Conclusions

There is a tendency toward better outcomes in women for immunotherapy in advanced or metastatic urothelial cancer, but only for the antibody atezolizumab women have a significantly better ORR. Unfortunately, many studies fail to report gender-specific outcomes. Therefore, further research is essential when aiming for individualized medicine. This research should address immunological confounders.
Barriers and applied activity, quality of life and self-efficacy in prostate cancer survivors 1 year after completing radiotherapy
Authors: Martín-Núñez Javier , Linares-Moya Marta , Calvache-Mateo Andrés , Lazo-Prados Antonio , Heredia-Ciuró Alejandro , López-López Laura , Valenza Marie Carmen
Published: April 2023

Purpose

The aims of the study were to assess self-reported physical activity (PA) levels, barriers to PA, quality of life and self-efficacy to manage chronic disease of prostate cancer survivor 1 year after radiotherapy treatment.

Methods

A cross-sectional case–control study was performed. Prostate cancer survivor patients treated with radiotherapy were recruited from the Radiation Oncology Service of the “Complejo Hospitalario Universitario” (Granada) and compared with age-matched healthy men. Outcomes included were perception of benefits for physical activity and potential barriers (Exercise Benefits/Barriers Scale), physical activity levels assessed by the International Physical Activity Questionnaire (IPAQ), quality of life (EuroQol five-dimension three-levels) and self-efficacy (Self-Efficacy to Manage Chronic Disease).

Results

A total of 120 patients were included in our study. Significant differences were found between groups with worse results for the prostate cancer patient group in the variable perception of the benefit of physical activity, potential barriers, and physical activity. Regarding quality of life and self-efficacy, significant differences were also observed between groups with a greater score in the control group.

Conclusion

In conclusion, the results of this study reveal that self-reported PA levels, as measured using the IPAQ, were low in prostate cancer survivors after treatment. Results also showed worse perception of benefits for PA and potential barriers by the cancer survivors. Similarly, the quality of life and self-efficacy to manage chronic disease of prostate cancer survivors was lower.
Combining deep reinforcement learning with technical analysis and trend monitoring on cryptocurrency markets
Authors: Kochliaridis Vasileios , Kouloumpris Eleftherios , Vlahavas Ioannis
Published: April 2023

Cryptocurrency markets experienced a significant increase in the popularity, which motivated many financial traders to seek high profits in cryptocurrency trading. The predominant tool that traders use to identify profitable opportunities is technical analysis. Some investors and researchers also combined technical analysis with machine learning, in order to forecast upcoming trends in the market. However, even with the use of these methods, developing successful trading strategies is still regarded as an extremely challenging task. Recently, deep reinforcement learning (DRL) algorithms demonstrated satisfying performance in solving complicated problems, including the formulation of profitable trading strategies. While some DRL techniques have been successful in increasing profit and loss (PNL) measures, these techniques are not much risk-aware and present difficulty in maximizing PNL and lowering trading risks simultaneously. This research proposes the combination of DRL approaches with rule-based safety mechanisms to both maximize PNL returns and minimize trading risk. First, a DRL agent is trained to maximize PNL returns, using a novel reward function. Then, during the exploitation phase, a rule-based mechanism is deployed to prevent uncertain actions from being executed. Finally, another novel safety mechanism is proposed, which considers the actions of a more conservatively trained agent, in order to identify high-risk trading periods and avoid trading. Our experiments on 5 popular cryptocurrencies show that the integration of these three methods achieves very promising results.
Clinical outcomes and complications after biportal endoscopic spine surgery: a comprehensive systematic review and meta-analysis of 3673 cases
Authors: Park Don Y. , Upfill-Brown Alexander , Curtin Nora , Hamad Christopher D. , Shah Akash , Kwon Brian , Kim Yong H. , Heo Dong Hwa , Park Cheol Woong , Sheppard William L.
Published: April 2023

Purpose

Current literature suggests that biportal spinal endoscopy is safe and effective in treating lumbar spine pathology such as lumbar disc herniation, lumbar stenosis, and degenerative spondylolisthesis. No prior study has investigated the postoperative outcomes or complication profile of the technique as a whole. This study serves as the first comprehensive systematic review and meta-analysis of biportal spinal endoscopy in the lumbar spine.

Methods

A PubMed literature search provided over 100 studies. 42 papers were reviewed and 3673 cases were identified with average follow-up time of 12.5 months. Preoperative diagnoses consisted of acute disc herniation (1098), lumbar stenosis (2432), and degenerative spondylolisthesis (229). Demographics, operative details, complications, and perioperative outcome and satisfaction scores were analyzed.

Results

Average age was 61.32 years, 48% male. 2402 decompressions, 1056 discectomies, and 261 transforaminal lumbar Interbody fusions (TLIFs) were performed. Surgery was performed on 4376 lumbar levels, with L4-5 being most common(61.3%). 290 total complications occurred, 2.23% durotomies, 1.29% inadequate decompressions, 3.79% epidural hematomas, and < 1% transient nerve root injuries, infections, and iatrogenic instability. Significant improvement in VAS-Back, VAS-Leg, ODI, and Macnab Scores were seen across the cohort.

Conclusion

Biportal spinal endoscopy is a novel method to address pathology in the lumbar spine with direct visualization through an endoscopic approach. Complications are comparable to previously published rates. Clinical outcomes demonstrate effectiveness. Prospective studies are required to assess the efficacy of the technique as compared to traditional techniques. This study demonstrates that the technique can be successful in the lumbar spine.
Interventions for perinatal borderline personality disorder and complex trauma: a systematic review
Authors: May Alexandra , Balzan Ryan , Williams Anne Sved , Wade Tracey D , Paranjothy Sarah Marie
Published: April 2023

Perinatal borderline personality disorder (BPD) and complex post-traumatic stress disorder (cPTSD) are associated with significant impairment to interpersonal functioning, and risk of intergenerational transmission of psychopathology. Evaluation of interventions, however, is scarce. To date, no systematic review has addressed interventions for perinatal BPD, cPTSD, and associated symptomatology. Given the modest evidence to support informed clinical guidelines, the objective of this systematic review is to synthesise the literature on interventions for perinatal BPD and cPTSD, and to generate future directions for research. A comprehensive literature search following PRISMA guidelines was conducted in PsycInfo, MEDLINE, Emcare, Scopus, and ProQuest Dissertations and Theses Global databases. Seven original studies were included, of which only two were randomised controlled trials, using less intensive comparison conditions. Results suggest an association between Dialectical Behavioural Therapy (DBT) group skills training, a multimodal therapeutic approach at a Mother-Baby Unit (MBU), and Child-Parent Psychotherapy with improved perinatal mental health outcomes and remission of symptoms. MBU admission and home-visiting programs were associated with healthy postpartum attachment relationships. Home-visiting programs and DBT group skills were additionally associated with improved maternal parenting capabilities. Conclusions to inform clinical guidelines are limited by a lack of credible comparison conditions, and low quantity and quality of evidence. The feasibility of implementing intensive interventions in real-world settings is dubious. Hence, it is suggested that future research considers utilising antenatal screening to identify at-risk mothers, and the implementation of early intervention, using robust designs that can inform robust conclusions.
Relations between personal exposure to elevated concentrations of arsenic in water and soil and blood arsenic levels amongst people living in rural areas in Limpopo, South Africa
Authors: Kapwata Thandi , Wright Caradee Y. , Reddy Tarylee , Street Renee , Kunene Zamantimande , Mathee Angela
Published: April 2023

Exposure to arsenic even at low levels can lead to adverse health outcomes, however, there is a paucity of research from South Africa in relation to human exposure to arsenic. We investigated long-term exposure of residents in Limpopo province, South Africa, in a cross-sectional study by analysing water, soil and blood arsenic concentrations from two arsenic-exposed (high and medium–low exposure) villages and one non-exposed (control) village. There were statistically significant differences in the distribution of arsenic in water, soil and blood amongst the three sites. The median drinking water arsenic concentration in the high-exposure village was 1.75 µg/L (range = 0.02 to 81.30 µg/L), 0.45 µg/L (range = 0.100 to 6.00 µg/L) in the medium- / low-exposure village and 0.15 µg/L (range =  < limit of detection (LOD) to 29.30 µg/L) in the control site. The median soil arsenic concentration in the high-exposure village was 23.91 mg/kg (range =  < LOD to 92.10 mg/kg) whilst arsenic concentrations were below the limit of detection in all soil samples collected from the medium-/low-exposure and control villages. In the high-exposure village, the median blood arsenic concentration was 1.6 µg/L (range = 0.7 to 4.2 µg/L); 0.90 µg/L (range =  < LOD to 2.5 µg/L) in the medium-/low-exposure village and 0.6 µg/L (range =  < LOD to 3.3 µg/L) in the control village. Significant percentages of drinking water, soil and blood samples from the exposed sites were above the internationally recommended guidelines (namely, 10 µg/L, 20 mg/kg and 1 µg/L, respectively). Majority of participants (86%) relied on borehole water for drinking and there was a significant positive correlation between arsenic in blood and borehole water (p-value = 0.031). There was also a statistically significant correlation between arsenic concentrations in participants’ blood and soil samples collected from gardens (p-value = 0.051). Univariate quantile regression found that blood arsenic concentrations increased by 0.034 µg/L (95% CI = 0.02–0.05) for each one unit increase in water arsenic concentrations (p < 0.001). After adjusting for age, water source and homegrown vegetable consumption in multivariate quantile regression, participants from the high-exposure site had significantly higher blood concentrations than those in the control site (coefficient: 1.00; 95% CI = 0.25–1.74; p-value = 0.009) demonstrating that blood arsenic is a good biomarker of arsenic exposure. Our findings also provide new evidence for South Africa on the association between drinking water and arsenic exposure, emphasising the need for the provision of potable water for human consumption in areas with high environmental arsenic concentrations.
Speed-Dating im beruflichen Kontext – welchen Beitrag können Techniken agiler Arbeit in Arbeitsgestaltungsprojekten leisten?
Authors: Hornung Rebecca , Rieder Kerstin
Published: April 2023

Während Befragungen von Mitarbeitenden in Unternehmen an der Tagesordnung sind, folgt daraus nicht immer eine konsequente Ableitung und Umsetzung von Arbeitsgestaltungsmaßnahmen. Das neu entwickelte Speed-Dating im beruflichen Kontext greift Techniken aus der agilen Arbeit auf, um dies auch bei knappen zeitlichen Ressourcen zu ermöglichen. Es zielt darauf ab, an Schnittstellen zwischen Berufsgruppen und Abteilungen ein verbessertes gegenseitiges Verständnis für die jeweils andere Tätigkeit zu entwickeln und unnötige Unterbrechungen im Arbeitsablauf abzubauen. Das Konzept wurde mit einer Gruppe von zehn Beschäftigten verschiedener Berufsgruppen im Krankenhaus praktisch erprobt und formativ evaluiert. Die Evaluationsergebnisse zeigen Verbesserungsmöglichkeiten auf und bestätigen den Nutzen der Maßnahme aus Sicht der Teilnehmenden. Möglichkeiten des Transfers der Maßnahme auf andere Organisationen werden diskutiert.
Digital platform ecosystems in flux: From proprietary digital platforms to wide-spanning ecosystems
Authors: Nerbel Jan Frederic , Kreutzer Markus
Published: April 2023

Digital Platform Ecosystems (DPEs) represent a distinct form of interorganizational relationship cultivated on digital infrastructures. Although DPEs are researched extensively among management scholars, shortcomings in formalizing their emergence remain. Particularly re-occurring patterns and temporal dimensions of emergence continue to be relatively unexplored. We review existing literature in an integrative manner and shed light on DPE emergence by deriving a framework comprising four distinct stages. We thereby sharpen the understanding of DPEs and bring convergence to an increasingly fragmented field of research by accounting for industrial innovation management, organizational, market-based, and ecosystem-based views. As a result, we present a classification of DPE emergence stages and related key activities contributing to the progression from a nascent digital platform into a wide-spanning DPE. Finally, we propose multiple avenues for future research.
A novel material-balance approach for estimating in-place volumes of gas and water in gas reservoirs with aquifer support
Authors: Jongkittinarukorn K. , Kabir C. S.
Published: April 2023

Applications of the traditional static material-balance method in gas reservoirs become a challenge with production maturity due to variability in aquifer influx, infill drilling, and production-operational changes in offset wells, among others. Besides, some existing modeling approaches involve a trial-and-error method, making the solution outcomes nontrivial. This study proposes a new methodology for analyzing production data involving water-drive gas reservoirs. The main findings of this study include the following: (1) A straight-line plot that yields gas and water in-place volumes, (2) A modified-(pav/z)* plot exhibits a straight-line with an x-intercept of gas initially-in-place, similar to that in a conventional-(pav/z) plot, (3) A new definition of degree of aquifer support that is quantifiable using production data. Synthetic data verified the proposed modeling approach, whereas a field dataset provided validation.
Aerodynamic model adjustment for an accurate flight performance representation using a large operational flight data base
Authors: Deiler Christoph
Published: April 2023

A novel process to determine an aircraft performance model from operational flight data with limited a priori knowledge is developed. The given big data problem is solved by application of fundamental engineering knowledge and a specific data evaluation strategy. The resulting smart data approach is fundamentally different from existing deep learning methods to solve such big data problems. A given aerodynamic model is updated to represent the characteristics of an Airbus A320neo aircraft based on a given large database of operational flights. The updated aerodynamic model implementation for one specific flap/slat configuration is exemplarily compared to the information available from flight data and the results are discussed in terms of model quality.
Progress of the Gulf Cooperation Council (GCC) Countries Towards Achieving the 95-95-95 UNAIDS Targets: A Review
Authors: Awaidy Salah Al , Ghazy Ramy Mohamed , Mahomed Ozayr
Published: April 2023

Background

In 2014, the Joint United Nations Programme on HIV/AIDS (UNAIDS) and partners launched the 90-90-90 targets. These were further updated to correspond to 95-95-95 by the year 2025. We present an overview of the progress made by Gulf Cooperated Council (GCC) countries towards meeting the global targets.

Methods

We extracted data from Global AIDS Monitoring (GAM), UNAIDS AIDS Info, HIV case reporting database, and the WHO global policy uptake for six countries: Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab of Emirates (UAE) to assess the HIV/AIDS burden in the six GCC countries, and the progress towards achieving the 95-95-95 goal.

Results

By the end of 2021, an estimated 42,015 people living with HIV (PLHIV) were residing in the GCC countries with prevalence levels below 0.01%. Data from four GCC countries, Bahrain, Oman, Qatar and UAE, indicated that by 2021, 94%, 80%, 66%, and 85% of HIV-positive population knew their status, respectively. 68%, 93% (2020 data), 65%, 58% and 85% of PLHIV in Bahrain, Kuwait, Oman, Qatar and UAE who knew their status were on anti-retroviral therapy (ART), respectively, and 55%, 92%, 58% and 90% (2020 data) among those who were on ART had viral suppression in Bahrain, Kuwait, Oman and KSA, respectively.

Conclusion

The GCC countries have made great strides toward fulfilling the 95-95-95 targets, but the interim 2025 overall UNAIDS targets remain unmet. The GCC countries must strive diligently to accomplish the targets by emphasising early identification of the cases by enhanced screening and testing, as well as prompt commencement of ART therapy with viral load suppression.
Meromorphic Dynamics
Authors: Kotus Janina , Urbański Mariusz
Published: April 2023

This text, the second of two volumes, builds on the foundational material on ergodic theory and geometric measure theory provided in Volume I, and applies all the techniques discussed to describe the beautiful and rich dynamics of elliptic functions. The text begins with an introduction to topological dynamics of transcendental meromorphic functions, before progressing to elliptic functions, discussing at length their classical properties, measurable dynamics and fractal geometry. The authors then look in depth at compactly non-recurrent elliptic functions. Much of this material is appearing for the first time in book or paper form. Both senior and junior researchers working in ergodic theory and dynamical systems will appreciate what is sure to be an indispensable reference.
Radio in Africa
Authors: Heinze Robert
Published: April 2023

Frantz Fanon’s essay “This is the Voice of Algeria” is a still-underused text in the study of radio. The book it comes from, A Dying Colonialism, is often regarded as one of Fanon’s weaker works, since its sociological studies of the Algerian revolution are considered to lack the rhetorical mastership and philosophical heft seen in his more famous books. At least in the case of his essay on radio, however, this perception is misguided, as recent literature on the history of radio in Africa shows.
Ideology Critique and Game Theory
Authors: Barrett Jacob
Published: April 2023

Ideology critics believe that many bad social practices persist because of ideology, and that critiquing ideology is an effective way to promote social reform. Skeptics draw on game theory to argue that the persistence of such practices is better explained by collective action problems, and that ideology critique is causally inefficacious. In this paper, I reconcile these camps. I show that while game theory can help us identify contexts where ideology critique makes no difference, it also reveals causal mechanisms by which ideology critique can have a significant effect. I then consider some objections and directions for further research.
M dwarfs found in the first Byurakan spectral sky survey database. Gaia EDR3 and TESS data. Some preliminary results
Authors: Gigoyan K. S. , Sarkissian A. , Kostandyan G. R. , Gigoyan K. K. , Meftah M. , Bekki S. , Azatyan N. , Zamkotsian F.
Published: April 2023

In order to gain more information on the 236 M dwarfs identified in the First Byurakan Survey (FBS) low-resolution (lr) spectroscopic database, Gaia EDR3 high-accuracy astrometric and photometric data and Transiting Exoplanet Survey Satellite (TESS) data are used to characterise these M dwarfs and their possible multiplicity. Among the sample of 236 relatively bright$(7.3 < K_S < 14.4)$M dwarfs, 176 are new discoveries. TheGaiaEDR3 G broadband magnitudes are in the range$11.3 < G < 17.1$. New distance information based on the EDR3 parallaxes are used to estimate theG-band absolute magnitudes. Nine FBS M dwarfs out of 176 newly discovered lie within 25 pc of the Sun. The FBS 0909-082 is the most distant$(r=780$pc) M dwarf of the analysed sample, with aG-band absolute magnitude$M(G) = 9.18$,$M = 0.59$M$_{\odot}$,$L = 0.13597$L$_{\odot}$, and$T_{eff}$= 3844 K; it can be classified as M1 - M2 subtype dwarf. The nearest is FBS 0250+167, a M7 subtype dwarf located at 3.83 pc from the Sun with a very high proper motion (5.13 arcsec yr$^{-1}$). The TESS estimated masses lie in the range 0.095 ($\pm$0.02) M$_{\odot}\leq$$M\leq$0.7 ($\pm$0.1) M$_{\odot}$and$T_{eff}$in the range 4000 K <$T_{eff}$< 2790 K. We analyse colour-colour and colour-absolute magnitude diagram (CaMD) diagrams for the M dwarfs. Results suggest that 27 FBS M dwarfs are double or multiple systems. The observed spectral energy distribution (SED) for some of the M dwarfs can be used to classify potential infrared excess. Using TESS light curves, flares are detected for some FBS M dwarfs. Finally, for early and late sub-classes of the M dwarfs, the detection range for survey is estimated for the first time.
Cartoon diplomacy: visual strategies, imperial rivalries and the 1890 British Ultimatum to Portugal
Authors: Diogo Maria Paula , Urze Paula , Simões Ana
Published: April 2023

This paper offers a novel interpretation of the 1890 British Ultimatum, by bringing to the front of the stage its techno-diplomatic dimension, often invisible in the canonical diplomatic and military narratives. Furthermore, we use an unconventional historical source to grasp the British–Portuguese imperial conflict over the African hinterland via the building of railways: the cartoons of the politically committed and polyvalent Portuguese artist and journalist Rafael Bordalo Pinheiro (1846–1905), published in his journal Ponto nos iis, from the end of 1889 and throughout 1890. We argue that the Ponto nos iis cartoons played a so far overlooked role in the unfolding of British–Portuguese affairs, as they shaped at a distance a diplomatic exchange with the British satirical journal Punch. Attacking and counterattacking his fellow cartoonists in Britain, Pinheiro surged into the role of informal diplomat. This cartoon visual and public diplomacy unfolded in the pages of both journals and was tied to the two countries’ colonial conquests in Africa, where the Portuguese and British empires were competing to dominate the African hinterland through large technological systems. Hence the cartoons made visible to wider audiences the otherwise hidden role that technologies played in the two countries’ affairs. In turn, the cartoons aimed at persuading the Portuguese public and ruling classes alike that only regime change, from monarchic to republican, would restore the wounded Portuguese national pride.
Division algebras and MRD codes from skew polynomials
Authors: Thompson D. , Pumplün S.
Published: April 2023

Let
$D$
be a division algebra, finite-dimensional over its center, and
$R=D[t;\;\sigma,\delta ]$
a skew polynomial ring.

Using skew polynomials
$f\in R$
, we construct division algebras and maximum rank distance codes consisting of matrices with entries in a noncommutative division algebra or field. These include Jha Johnson semifields, and the classes of classical and twisted Gabidulin codes constructed by Sheekey.
Crystal structure of butenafine hydrochloride, C23H28NCl
Authors: Kaduk James A. , Gates-Rector Stacy , Blanton Thomas N.
Published: April 2023

The crystal structure of butenafine hydrochloride has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory techniques. Butenafine hydrochloride crystallizes in space group P21 (#4) with a = 13.94807(5), b = 9.10722(2), c = 16.46676(6) Å, β = 93.9663(5)°, V = 2086.733(8) Å3, and Z = 4. Butenafine hydrochloride occurs as a racemic co-crystal of R and S enantiomers of the cation. The crystal structure is characterized by parallel stacks of aromatic rings along the b-axis. Each cation forms a strong discrete N–H⋯Cl hydrogen bond. The chloride anions also act as acceptors in several C–H⋯Cl hydrogen bonds from methylene, methyl, and aromatic groups. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™ (PDF®).
The experiences of physiotherapy independent prescribing in primary care: implications for practice
Authors: Mullan Jacqueline , Smithson Janet , Walsh Nicola
Published: April 2023

Aim:

To explore the experiences of musculoskeletal (MSk) physiotherapy independent prescribing in primary care from the perspectives of physiotherapists and General Practitioners (GPs) and identify the implications these have for contemporary physiotherapy practice in primary care.

Background:

Legislative change in the United Kingdom (UK) in 2013 enabled physiotherapists holding a postgraduate non-medicalprescribing qualification to independently prescribe certain drugs that assist in patient management. Independent prescribing by physiotherapists is a relatively contemporary development in role change and purpose, occurring alongside the development of physiotherapy first contact practitioner (FCP) roles in primary care.

Methods:

A critical realist approach was used, with qualitative data collected via 15 semi-structured interviews with physiotherapists and GPs in primary care. Thematic analysis was applied.

Participants:

Fifteen participants were interviewed (13 physiotherapists, 2 GPs). Of the 13 physiotherapists, 8 were physiotherapy independent prescribers, 3 were MSk service leads, and 3 were physiotherapy consultants. Participants worked across 15 sites and 12 organisations.

Findings:

Whilst physiotherapists were empowered by their independent prescribing qualification, they were frustrated by current UK Controlled Drugs legislation. Physiotherapists reported vulnerability, isolation, and risk as potential challenges to independent prescribing, but noted clinical experience and ‘patient mileage’ as vital to mitigate these. Participants identified the need to establish prescribing impact, particularly around difficult to measure aspects such as more holistic conversations and enhanced practice directly attributed to prescribing knowledge. GPs were supportive of physiotherapists prescribing.

Conclusions:

Establishment of physiotherapy independent prescribing value and impact is required to evaluate the role of, and requirement for, physiotherapy independent prescribers within primary care physiotherapy FCP roles. Additionally, there is a need for a review of physiotherapy prescribing permitted formulary, and development of support mechanisms for physiotherapists at individual and system levels to build prescribing self-efficacy and autonomy, and to advance and sustain physiotherapy independent prescribing in primary care.
Biocultural Calendars Across Four Ethnolinguistic Communities in Southwestern South America
Authors: Rozzi Ricardo , Álvarez Ricardo , Castro Victoria , Núñez David , Ojeda Jaime , Tauro Alejandra , Massardo Francisca
Published: April 2023

Since the mid‐20th century, the so‐called Great Acceleration (sensu Steffen et al., 2007, https://doi.org/10.1579/0044-7447(2007)36[614:TAAHNO]2.0.CO;2) has amplified processes of ecosystem degradation, extinction of biological species, displacement of local peoples, losses of languages, and cultural diversity. These losses are still underperceived by the academic community, and by a global society that is disconnected from biocultural diversity. To reconnect society with biocultural diversity, we integrate temporal and spatial dimensions of seasonal cycles, by combining two conceptual frameworks: ecological calendars and the “3Hs” model of the biocultural ethic (sensu Rozzi, 2012, https://doi.org/10.5840/enviroethics20123414). The latter values the vital links between human and other‐than‐human co‐inhabitants, their life habits (e.g., cultural practices of humans or life cycles of other‐than‐human species), and the structure and processes of their shared habitats. This integration enhances an understanding of links between cultural practices and the life cycles of biocultural keystone species. As a synthesis, we use the term biocultural calendars to emphasize their co‐constitutive nature that result from interactions between dynamic biophysical and cultural processes embedded in specific ecosystems and cultures. These calendars link astronomical, biological, and cultural seasonal cycles that sustain life and enhance the integration of Indigenous and scientific knowledge to confront challenges of climate change faced from local to global scales. To illustrate this integration, we examine cultural practices and socio‐environmental changes across four contrasting ethnolinguistic communities in southwestern South America, from southern to northern Chile along a marked climatic gradient to show the broad application of the concept of biocultural calendars.
Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer
Authors: Zhou Jie , Chen Guanming , Wang Jiuling , Zhou Bo , Sun Xuemin , Wang Jinsong , Tang Shu , Xing Xiangju , Hu Xiaofei , Zhao Yang , Peng Yu , Shi Wenjiong , Zhao Tingting , Wu Yuzhang , Zhong Hanbing , Hong Ni , Ruan Zhihua , Zhang Yi , Jin Wenfei
Published: April 2023

Anti-PD-1 therapy has shown promising outcomes in the treatment of different types of cancer. It is of fundamental interest to analyze the efficacy of anti-PD-1 therapy in cancer patients infected with hepatitis B virus (HBV) since the comorbidity of HBV and cancer is widely documented. We designed a multicenter retrospective study to evaluate the efficacy of anti-PD-1 therapy on non-liver cancer patients infected with HBV. We found anti-PD-1 therapy achieved much better outcomes in HBV+ non-liver cancer patients than their HBV– counterparts. We performed single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear cells (PBMCs) from esophageal squamous cell carcinoma (ESCC) patients. We found both cytotoxicity score of T cells and MHC score of B cells significantly increased after anti-PD-1 therapy in HBV+ ESCC patients. We also identified CX3CR1high TEFF, a subset of CD8+ TEFF, associated with better clinical outcome in HBV+ ESCC patients. Lastly, we found CD8+ TEFF from HBV+ ESCC patients showing higher fraction of Exhaustionhi T than their HBV– counterpart. In summary, anti-PD-1 therapy on HBV+ non-liver cancer patients is safe and achieves better outcomes than that on HBV– non-liver cancer patients, potentially because HBV+ patients had higher fraction of Exhaustionhi T, which made them more efficiently respond to anti-PD-1 therapy.
Correlation-driven organic 3D topological insulator with relativistic fermions
Authors: Nomoto Tetsuya , Imajo Shusaku , Akutsu Hiroki , Nakazawa Yasuhiro , Kohama Yoshimitsu
Published: April 2023

Exploring new topological phenomena and functionalities induced by strong electron correlation has been a central issue in modern condensed-matter physics. One example is a topological insulator (TI) state and its functionality driven by the Coulomb repulsion rather than a spin-orbit coupling. Here, we report a ‘correlation-driven’ TI state realized in an organic zero-gap system α-(BETS)2I3. The topological surface state and chiral anomaly are observed in temperature and field dependences of resistance, indicating a three-dimensional TI state at low temperatures. Moreover, we observe a topological phase switching between the TI state and non-equilibrium Dirac semimetal state by a dc current, which is a unique functionality of a correlation-driven TI state. Our findings demonstrate that correlation-driven TIs are promising candidates not only for practical electronic devices but also as a field for discovering new topological phenomena and phases.