bluuebunny/crossref_metadata_2025 huggingface dataset:
Salvaging Utopia: Lessons for (and from) the Left in Rivers Solomon’s An Unkindness of Ghosts (2017), The Deep (2019), and Sorrowland (2021)
Authors: de Bruin-Molé Megen
Published: October 2021

In response to this special issue’s question of whether mainstream science fiction has become stuck in presentism and apocalypticism, this article examines how utopia is expressed and salvaged in the work of Rivers Solomon. Using three of Solomon’s novels and the theoretical lenses of black utopia studies and salvage-Marxism, I suggest that scholars and activists should approach this question from a different perspective. While Solomon’s novels may seem dystopian from the perspective of liberalism or whiteness, they can also clearly be placed within the long, if marginalized, history of leftist and black utopian thought. Likewise, where the ‘traditional’ utopia (a concept I interrogate) is often imagined as grounded in hope and futurity, black utopia and salvage-Marxism reject these concepts as counterproductive to the actual work of social justice and utopia-building. Despite their presentism and apocalypticism, then, I argue Solomon’s novels are very much utopian: they simply locate their utopian desire in radical kinship and salvage, rather than universalism or futurity.
Increased Involvement of Klebsiellapneumoniae and Enterococcusfaecium in Healthcare-Associated Infections of Intensive Care Units in Taiwan
Authors: Lin Yu-Ren , Lin Yen-Yue , Yu Chia-Peng , Yang Ya-Sung , Cheng Chun-Gu , Cheng Chun-An
Published: October 2021

Background: Healthcare-associated infections (HAIs) cause increases in length of stay, mortality, and healthcare costs. A previous study conducted in Taiwan obtained similar results to those reported in Korea and Japan in 2015. Changes in microorganisms have been noted in recent years. Understanding the recent condition of HAIs in intensive care units (ICUs) can enable healthcare providers to develop effective infection control protocols to reduce HAIs. Methods: We used the Taiwan Nosocomial Infection Surveillance System to evaluate the incidence densities of HAIs, the proportions of causative pathogens, and the proportions of antimicrobial resistance (AMR). The Poisson regression model was constructed to incidence density, and the chi-square test was used to assess proportion. Results: The incidence density of HAIs decreased 5.7 to 5.4 per 1000 person-days. However, the proportions of Klebsiella pneumoniae and Enterococcus faecium significantly increased. In addition, the proportions of carbapenem-resistant K. pneumoniae and vancomycin-resistant Enterococcus faecium significantly increased over time. Conclusion: Analysis of the microorganisms involved in HAIs in ICUs showed elevated proportions of K. pneumoniae and E. faecium with AMR. Infection control protocols have been implemented for several years and require improvements regarding environmental cleanliness and medical staff prevention.
Determinants of Healthcare Use Based on the Andersen Model: A Systematic Review of Longitudinal Studies
Authors: Hajek André , Kretzler Benedikt , König Hans-Helmut
Published: October 2021

The aim was to give an overview of longitudinal observational studies investigating the determinants of healthcare use explicitly using the Andersen model. To this end, three electronic databases (Medline, PsycINFO and CINAHL) were searched (and an additional hand search was performed). Longitudinal observational studies examining the determinants of healthcare use (outpatient physician services and hospital stays) based on the Andersen model were included, whereas disease-specific samples were excluded. Study quality was evaluated. The selection of studies, extraction of data and assessment of the studies were conducted by two reviewers. The following determinants of healthcare use were displayed based on the (extended) Andersen model: predisposing characteristics, enabling resources, need factors and psychosocial factors. In sum, n = 10 longitudinal studies have been included in our systematic review. The included studies particularly showed a longitudinal association between increased needs and higher healthcare use. Study quality was rather high. However, several studies did not conduct robustness checks or clarify the handling of missing data. In conclusion, this systematic review adds to our current understanding of the factors associated with healthcare use (mainly based on cross-sectional studies). It showed mixed evidence with regard to the association between predisposing characteristics, enabling resources and healthcare use longitudinally. In contrast, increased need factors (in particular, self-rated health and chronic conditions) were almost consistently associated with increased healthcare use. This knowledge may assist in managing healthcare use. Since most of the studies were conducted in North America or Europe, future longitudinal studies from other regions are urgently required.
Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis
Authors: Morgan Gareth J. , Buxbaum Joel N. , Kelly Jeffery W.
Published: October 2021

Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in many patients impaired organ function remains. The impairment is apparently due to a subset of resistant plasma cells that continue to secrete misfolding-prone light chains. These light chains are susceptible to the proteolytic cleavage that may enable light chain aggregation. We propose that small molecules that preferentially bind to the natively folded state of full-length light chains could act as pharmacological kinetic stabilizers, protecting light chains against unfolding, proteolysis and aggregation. Although the sequence of the pathological light chain is unique to each patient, fortunately light chains have highly conserved residues that form binding sites for small molecule kinetic stabilizers. We envision that such stabilizers could complement existing and emerging therapies to benefit light chain amyloidosis patients.
Geochemical-Microscopical Characterization of the Deterioration of Stone Surfaces in the Cloister of Santa Maria in Vado (Ferrara, Italy)
Authors: Marrocchino Elena , Telloli Chiara , Leis Marilena , Vaccaro Carmela
Published: October 2021

Santa Maria in Vado is a monument in the rich artistic heritage of the city of Ferrara (north of Italy). In this paper we want to investigate the state of conservation of tombstones, cloister and the entrance to the basilica, in order to keep them in the best possible state for the future generations. From the chemical characterization, the state of conservation was determined focusing on the biodeteriogenic and non-biodeteriogenic factors, which determine a series of unwanted changes in the physical, mechanical and above all aesthetic properties of the material, often closely connected with the environment and conservation conditions. On the macroscopic observation, the state of conservation of the tombstones appeared to be very deteriorated through aesthetic and structural damage. In detail, the stereo microscope observation of samples collected from the tombstones show the presence of efflorescence probably caused by the abundant of water that bring the salts present inside the rock into solution. Relating the columns, μ-XRF analysis confirm the carbonate composition of samples and presence of iron and sulfur. Finally, SEM observation highlighted the presence of black crust on arch samples and the presence of pollen on the black crust and spheroidal particles probably related to atmospheric pollution.
A Scan-to-BIM Methodology Applied to Stone Pavements in Archaeological Sites
Authors: Intignano Mattia , Biancardo Salvatore Antonio , Oreto Cristina , Viscione Nunzio , Veropalumbo Rosa , Russo Francesca , Ausiello Gigliola , Dell’Acqua Gianluca
Published: October 2021

The transition from Building Information Modelling (BIM) to Heritage Building Information Modelling (H-BIM) is intended to pursue an adequate knowledge of the artefact that is to be preserved, progressively replacing the traditional methods of restoration and structural reinforcement projects with new tools for the management of both existing information and new interventions. The aim of the paper is to show the application of the H-BIM method to a stone pavement road located in the Archaeological Site of Pompeii. In detail, starting from a laser scanner-based survey, juxtaposed with coordinated points georeferenced through a total station, point clouds were handled by means of several BIM-based tools to perform the road design process, starting from the digital elevation model (DEM) and proceeding to the corridor representation. Subsequently, a visual programming application based on Python language was adopted to update the corridor information by means of the object property set. As preliminary results, a tool, complete with graphical and non-graphical information, is proposed to be used in conservation, maintenance and restoration projects.
Art Casting in Portuguese 19th Century Industrial Foundries: A Multi-Analytical Study of an Emblematic Copper-Based Alloy Monument
Authors: General-Toro Pablo , Bordalo Rui , Moreira Patrícia Raquel , Vieira Eduarda , Brunetti Antonio , Iannaccone Roberta , Bottaini Carlo
Published: October 2021

The outdoor sculpture of the first Portuguese king, D. Afonso Henriques (c. 1109–1185 AD), placed in Guimarães (North Portugal), is one of the most emblematic national sculptures. Created in 1887 by António Soares dos Reis, it possesses a remarkable symbolic value in the presumed birthplace of the king. In addition to the artistic and heritage importance of the monument, it is one of the few sculptures cast by a Portuguese industrial foundry in the 19th century. This study obtained data on the sculpture’s elemental composition and corrosion products, gathering important historical and technical information. For this purpose, a multi-analytical approach consisting of X-ray fluorescence (XRF), X-ray diffraction (XRD), optical microscopy (OM) and scanning electron microscopy (SEM-EDS) was carried out to characterise the bulk metal and corrosion layers. The data revealed a ternary alloy of Cu, Sn and Zn, with Pb, Fe, As, Bi and Mn as minor elements. The alloy matches that of other sculptures cast in that period. In terms of corrosion, it is characterised by the presence of oxides. These results represent the first step for applying an appropriate conservation strategy for bronze sculptures with similar characteristics.
Kalymnos Island, SE Aegean Sea: From Fishing Sponges and Rock Climbing to Geotourism Perspective
Authors: Zafeiropoulos George , Drinia Hara
Published: October 2021

The island of Kalymnos, located in the Dodecanese island complex in the SE Aegean, is known for its sponge fishing but also for its world-famous climbing fields. Indeed, the island is considered the “Mecca” of climbers. Nevertheless, Kalymnos is characterized by moderate tourist traffic and lack of tourism infrastructure. The planning and development of geotourism can be a driving force for the economic sustainability of the island. In this study, the possibility of developing the innovative and alternative form of geotourism on the island of Kalymnos is explored. Kalymnos is characterized by numerous caves and steep slopes which can be geotopes attractive to visitors. Six caverns and two climbing fields were analyzed as part of our investigation. For the quantitative assessment of the geosites three factors are considered: the potential educational use (PEU), the potential touristic use (PTU), and the degradation risk (DR). The quantitative evaluation in combination with a SWOT analysis showed that there is indeed a possibility of promotion and development of geotourism in combination with the protection of the island’s geotopes. This will give additional impetus to the economy of Kalymnos. However, the lack of awareness from local authorities and residents is evident. The need for training in matters related to the geological heritage is necessary. In this way, there will be geotourism development, contributing positively to the economic prosperity and sustainability of the island.
Assessing the Performance of Current Strategic Policy Directions towards Unfolding the Potential of the Culture–Tourism Nexus in the Greek Territory
Authors: Lampropoulos Vasileios , Panagiotopoulou Maria , Stratigea Anastasia
Published: October 2021

In the UN Agenda 2030, tourism acquires a salient position as a critical sector, directly or indirectly influencing a number of Sustainable Development Goals (SDGs). The pursuit of Sustainable Tourism (ST) is founded on the respectful exploitation of the sector’s core ‘raw material’, i.e., the precious and vulnerable nexus of natural and cultural heritage, and a cooperative multi-actor endeavor of all those having a stake in this shared good. Strategic tourism policy decisions, formulated at the state level, frame actors’ actions, favoring a balance among economic, societal and environmental goals; and a transparent, concrete and supportive investment landscape, allowing the tourism sector to blossom. But how successful are these policy decisions in promoting a sustainable, resilient and durable tourism model by instigating the entrepreneurial community to invest in the vibrant culture–tourism complex? An effort to respond to this concern is made in this work, grounded in the ‘Culture–Tourism–Policy’ triptych and their interaction, the ‘policy cycle’ as a means of assessing policy performance towards establishing a sustainable/resilient ‘marriage’ of ‘Culture–Tourism’, and GIS-enabled spatial data management for an evidence-based assessment of policy outcomes. These three factors are closely intertwined in the assessment of strategic tourism policy decisions’ performance in a culturally vibrant and highly reputed destination, Greece.
XRF Imaging (MA-XRF) as a Valuable Method in the Analysis of Nonhomogeneous Structures of Grisaille Paint Layers
Authors: Bernady Edyta , Goryl Maria , Walczak Małgorzata
Published: October 2021

Stained glass paint layers made with vitreous paints can be a challenging subject for analyses. Their heterogenic structure requires proper experimental methodology in order to obtain valuable data. The main goal of this paper is to present the advantages of macro-XRF scanning (MA-XRF) in the non-destructive investigation of historical grisaille paint layers on the basis of research conducted on seven stained glass panels from the Dominican Monastery in Kraków, the Diocesan Museum in Kielce and the National Museum in Poznań (Poland). The obtained results showed the capabilities of MA-XRF scanning in technology recognition, the legibility of damaged fragments of painted depictions, as well as with distinguishing the elemental composition between vitreous paints in different colours. Additionally, SEM-EDS measurements are presented so as to acquire quantitative results and additional information concerning light elements.
Use of Theory-Driven Report Back to Promote Lung Cancer Risk Reduction
Authors: Huntington-Moskos Luz , Rayens Mary Kay , Wiggins Amanda T. , Butler Karen M. , Hahn Ellen J.
Published: October 2021

Report back is active sharing of research findings with participants to prompt behavior change. Research on theory-driven report back for environmental risk reduction is limited. The study aim is to evaluate the impact of a stage-tailored report back process with participants who had high home radon and/or air nicotine levels. An observational one-group pre-post design was used, with data collection at 3, 9, and 15 months post intervention. Participants from the parent study (N = 515) were randomized to the treatment or control group and this sample included all 87 treatment participants who: (1) had elevated radon and/or air nicotine at baseline; and (2) received stage-tailored report back of their values. Short-term test kits measured radon; passive airborne nicotine samplers assessed secondhand smoke (SHS) exposure. Stage of action was categorized as: (1) ‘Unaware’, (2) ‘Unengaged’, (3) ‘Deciding’, (4) ‘Action’, and (5) ‘Maintenance’. Interventions were provided for free, such as in-person radon and SHS test kits and a brief telephonic problem-solving consultation. Stage of action for radon mitigation and smoke-free policy increased from baseline to 3 months and remained stable between 3 and 9 months. Stage of action for radon was higher at 15 months than baseline. Among those with high baseline radon, observed radon decreased by 15 months (p < 0.001). Tailored report back of contaminant values reduced radon exposure and changed the health behavior necessary to remediate radon and SHS exposure.
Obstetricians’ Attitude towards Childbirth
Authors: González-Mesa Ernesto , Jiménez-López Jesús , Blasco-Alonso Marta , Lubián-López Daniel
Published: October 2021

(1) Background: In Spain, as in other countries, there is an increase in policies and practices focused on the humanization of perinatal care. In this regard, the quality of interpersonal interactions between women and health professionals is one of the main factors, and, apart from other factors, it is influenced by health professionals´ attitudes towards childbirth. The main objective of this study was to determine the attitudes of obstetricians towards the humanization of childbirth and the promotion of a positive childbirth experience. (2) Methods: The psychosocial task force of the Spanish Society of Obstetrics and Gynecology designed a nationwide online survey. The questionnaire on attitudes towards childbirth (CAVE, acronym for “cuestionario de actitudes sobre vivencias y experiencias en el parto”) was used for the assessment. Exploratory and confirmatory factor analyses of the scale were also performed. (3) Results: A total of 384 participants completed the survey. Obstetricians showed a high-quality clinical obstetric performance, but some difficulties in identifying birth-related psychological-trauma risk factors. Some differences according to practice and gender were found in the final score and in areas regarding psychosocial risk, pain, accompaniment, and women´s expectations. (4) Conclusions: In light of the results, it is advisable to launch education initiatives aimed to improve interaction with pregnant women.
Local and Remote Ischemic Preconditioning Improves Sprint Interval Exercise Performance in Team Sport Athletes
Authors: Cheng Ching-Feng , Kuo Yu-Hsuan , Hsu Wei-Chieh , Chen Chu , Pan Chi-Hsueh
Published: October 2021

The aim of this study was to investigate the effects of local (LIPC) and remote (RIPC) ischemic preconditioning on sprint interval exercise (SIE) performance. Fifteen male collegiate basketball players underwent a LIPC, RIPC, sham (SHAM), or control (CON) trial before conducting six sets of a 30-s Wingate-based SIE test. The oxygen uptake and heart rate were continuously measured during SIE test. The total work in the LIPC (+2.2%) and RIPC (+2.5%) conditions was significantly higher than that in the CON condition (p < 0.05). The mean power output (MPO) at the third and fourth sprint in the LIPC (+4.5%) and RIPC (+4.9%) conditions was significantly higher than that in the CON condition (p < 0.05). The percentage decrement score for MPO in the LIPC and RIPC condition was significantly lower than that in the CON condition (p < 0.05). No significant interaction effects were found in pH and blood lactate concentrations. There were no significant differences in the accumulated exercise time at ≥80%, 90%, and 100% of maximal oxygen uptake during SIE. Overall, both LIPC and RIPC could improve metabolic efficiency and performance during SIE in athletes.
Barriers and Motivators to Physical Activity Prior to Starting a Community-Based Walking Program
Authors: Richards Elizabeth A. , Woodcox Stephanie
Published: October 2021

Despite the clear benefits of an active lifestyle, most American adults fail to meet physical activity (PA) guidelines. Because of its safety and ease, walking is a promising population-level strategy to increase PA. There is a need to further understand why adults do and do not participate in walking. This study provides a broader understanding of barriers and motivators of walking prior to starting a walking program. Four years of baseline data from a community-based walking program were analyzed (n = 1491). Descriptive statistics summarized participant characteristics, barriers, reinforcements, and current PA. Chi-square tests were used to assess differences in the barrier and reinforcement responses between participant’s PA level and age categories. Open-ended responses were analyzed using thematic analysis. On average, participants were white (96%), middle-aged (52 ± 13 years old) females (92%). Poor weather and time were frequently reported barriers to walking. Open-ended responses (n = 141) identified additional barriers of lack of motivation (n = 37), joint issues (n = 29), fatigue (n = 24), safety or lack of environmental supports (n = 17), family or work demands (n = 15), and lacking a walking partner (n = 9). Good weather, health, and weight loss were frequently reported motivators. Additional motivators (n = 282) identified included stress relief and mental health (n = 82), social time (n = 70), dog care (n = 41), other health benefits (n = 38), connect with nature (n = 19), enjoyment (14), occupation (n = 11), and environmental and community supports (n = 6). Findings highlight the importance of understanding participant barriers and motivators for PA before starting a program. Future research should examine how reported barriers and motivators are related to program completion and adherence. Tailoring community-based programs to address specific barriers and motivators may enable more participants to effectively change and maintain PA.
Tuberculosis Treatment Outcome and Predictors in Africa: A Systematic Review and Meta-Analysis
Authors: Teferi Melese Yeshambaw , El-Khatib Ziad , Boltena Minyahil Tadesse , Andualem Azeb Tarekegn , Asamoah Benedict Oppong , Biru Mulatu , Adane Hawult Taye
Published: October 2021

This review aimed to summarize and estimate the TB treatment success rate and factors associated with unsuccessful TB treatment outcomes in Africa. Potentially eligible primary studies were retrieved from PubMed and Google Scholar. The risk of bias and quality of studies was assessed using The Joanna Briggs Institute’s (JBI) appraisal criteria, while heterogeneity across studies was assessed using Cochran’s Q test and I2 statistic. Publication bias was checked using the funnel plot and egger’s test. The protocol was registered in PROSPERO, numbered CRD42019136986. A total of 26 eligible studies were considered. The overall pooled estimate of TB treatment success rate was found to be 79.0% (95% CI: 76–82%), ranging from 53% (95% CI: 47–58%) in Nigeria to 92% (95% CI: 90–93%) in Ethiopia. The majority of unsuccessful outcomes were attributed to 48% (95% CI: 40–57%) death and 47% (95% CI: 39–55%) of defaulter rate. HIV co-infection and retreatment were significantly associated with an increased risk of unsuccessful treatment outcomes compared to HIV negative and newly diagnosed TB patients with RR of 1.53 (95% CI: 1.36–1.71) and 1.48 (95% CI: 1.14–1.94), respectively. TB treatment success rate was 79% below the WHO defined threshold of 85% with significant variation across countries. Countries need to explore contextual underlining factors and more effort is required in providing TB preventive treatment, improve case screening and linkage for TB treatment among HIV high-risk groups and use confirmatory TB diagnostic modality. Countries in Africa need to strengthen counseling and follow-up, socio-economic support for patients at high risk of loss to follow-up and poor treatment success is also crucial for successful TB control programs.
Changes in Physical Activity Are Associated with Corresponding Changes in Psychological Well-Being: A Pandemic Case Study
Authors: Dahlen Micael , Thorbjørnsen Helge , Sjåstad Hallgeir , von Heideken Wågert Petra , Hellström Charlotta , Kerstis Birgitta , Lindberg Daniel , Stier Jonas , Elvén Maria
Published: October 2021

Societal crises and personal challenges are often followed by substantial changes in physical activity. Is there a link between such changes and psychological well-being? Seeking to answer this question, we conducted a correlational study on a representative sample in Sweden during the first year of the COVID-19 pandemic (N = 1035). About 49% of the sample had decreased their physical activity compared to their self-reported activity level prior to the pandemic, whereas 32% had increased it. The results showed a positive and robust association between changes in daily activity level and corresponding changes in psychological well-being. Specifically, individuals who had reduced their physical activity over the last year reported lower life satisfaction than before, and individuals who had increased their physical activity reported higher life satisfaction than before. The amount of complete physical inactivity (sitting) showed a similar pattern as the exercise data, meaning that individuals who reported increasing inactivity per day also reported a greater decline in life satisfaction. Additional analyses showed that the association between daily activity level and life satisfaction was somewhat stronger for men than for women, but there was no difference when comparing individual versus organized activities. The current study was based on a cross-sectional design, measuring self-reported change over time. Recent work from other research teams have used longitudinal data and experience-sampling in different settings, finding similar results. We conclude that there is good reason to recommend physical exercise as a coping strategy in difficult times.
A Profile of Novice and Senior Nurses’ Communication Patterns during the Transition to Practice Period: An Application of the Roter Interaction Analysis System
Authors: Chao Li-Fen , Guo Su-Er , Xiao Xaviera , Luo Yueh-Yun , Wang Jeng
Published: October 2021

Novice nurses’ successful transition to practice is impacted by their interactions with senior nurses. Ensuring that novice nurses are adequately supported during their transition to practice has wide-ranging and significant implications. The aim of this study is to explore the communication patterns between novice and senior nurses by applying an interaction analysis technique. Trimonthly onboarding evaluations between novice and senior nurses were recorded. The Roter Interaction Analysis System was adapted and deployed to identify communication patterns. In total, twenty-two interactions were analyzed. Senior nurses spoke more (64.5%). Task-focused exchange was predominant amongst senior (79.7%) and novice (59.5%) nurses. Senior nurses’ talk was concentrated in clusters of information-giving (45%) and advice or instructions (17.2%), while emotional expression (1.4%) and social talk (0.4%) were rare. Novice nurses’ talk was concentrated in clusters-information giving (57%) and positive talk (39.5%). The communication patterns between senior and novice nurses during the onboarding period indicate aspects of novice nurse transition that could be addressed, such as encouraging novice nurses to use these interactions to communicate more, or emphasizing the importance of social talk. These insights can be used to inform mentorship and preceptorship training to ensure that senior nurses are able to adequately support novice nurses through all parts of the transition to practice period.
Reliability of Repeated Trials Protocols for Body Composition Assessment by Air Displacement Plethysmography
Authors: Muntean Paul , Micloș-Balica Monica , Popa Anca , Neagu Adrian , Neagu Monica
Published: October 2021

Air displacement plethysmography (ADP) is fast, accurate, and reliable. Nevertheless, in about 3% of the cases, standard ADP tests provide rogue results. To spot these outliers and improve precision, repeated trials protocols have been devised, but few works have addressed their reliability. This study was conducted to evaluate the test–retest reliabilities of two known protocols and a new one, proposed here. Ninety-two healthy adults (46 men and 46 women) completed six consecutive ADP tests. To evaluate the reliability of single measurements, we used the results of the first two tests; for multiple measures protocols, we computed the test result from trials 1–3 and the retest result from trials 4–6. Bland–Altman analysis revealed that the bias and the width of the 95% interval of agreement were smaller for multiple trials than for single ones. For percent body fat (%BF)/fat-free mass, the technical error of measurement was 1% BF/0.68 kg for single trials and 0.62% BF/0.46 kg for the new protocol of multiple trials, which proved to be the most reliable. The minimal detectable change (MDC) was 2.77% BF/1.87 kg for single trials and 1.72% BF/1.26 kg for the new protocol.
Challenges in Diabetic Micro-Complication Management: Focus on Diabetic Neuropathy
Authors: Ansari Prawej , Hannan J.M.A. , Azam Shofiul , Jakaria Md.
Published: October 2021

The progression of diabetes leads to macro and microvascular complications, including diabetic neuropathy, which is the most prevalent microvascular complication with diabetes. Clinical manifestations of diabetic neuropathy begin with the loss of distal sensory function, pain, and substantial morbidity. It has been evident that ~50% of diabetic patients develop neuropathy at a certain stage in their lifetime. Interestingly, two major subtypes (type I and II) of diabetes do not share the same epidemiology and pathophysiology of diabetic neuropathy; thus, their management or treatment strategies may vary from each other. The past few decades of research suggest that many etiological features, diagnosis, and management complexities depend on the type of diabetes. However, the underlying mechanism of neuropathy in type I and type II diabetes remains unclear. This review provides the current knowledge on successful assessment, management, and pharmacological biomarkers to explore the treatment and surpass current challenges in diabetic neuropathy.
Nursing Informatics: Consumer-Centred Digital Health
Authors: Skiba Diane , Honey Michelle
Published: October 2021

In the past, nursing informatics has tended to focus on the implementation of systems [...]
Identifying Benchmarks for Failure Prediction in Industry 4.0
Authors: Diallo Mouhamadou Saliou , Mokeddem Sid Ahmed , Braud Agnès , Frey Gabriel , Lachiche Nicolas
Published: October 2021

Industry 4.0 is characterized by the availability of sensors to operate the so-called intelligent factory. Predictive maintenance, in particular, failure prediction, is an important issue to cut the costs associated with production breaks. We studied more than 40 publications on predictive maintenance. We point out that they focus on various machine learning algorithms rather than on the selection of suitable datasets. In fact, most publications consider a single, usually non-public, benchmark. More benchmarks are needed to design and test the generality of the proposed approaches. This paper is the first to define the requirements on these benchmarks. It highlights that there are only two benchmarks that can be used for supervised learning among the six publicly available ones we found in the literature. We also illustrate how such a benchmark can be used with deep learning to successfully train and evaluate a failure prediction model. We raise several perspectives for research.
Heat Shock Protein 70 Family in Response to Multiple Abiotic Stresses in the Silkworm
Authors: Fang Shou-Min , Zhang Qian , Zhang Yu-Li , Zhang Gui-Zheng , Zhang Ze , Yu Quan-You
Published: October 2021

The 70 kDa heat shock proteins play important roles in protecting organisms against environmental stresses, which are divided into stress-inducible forms (HSP70s) and heat shock cognates (HSC70s). In this study, heat shock protein 70 family was identified in the whole genome of the silkworm. Based on the known nomenclature and phylogenetic analysis, four HSP70s and five HSC70s were classified. Relatively, heat shock cognates were more conservative and were constitutively expressed in various tissues of the silkworm larvae. Under thermal (37 °C and 42 °C) and cold (2 °C) stresses, the expressions of HSP70–1, HSP70–2, and HSP70–3 were up-regulated, and the highest induction reached 4147.3, 607.1, and 1987.3 times, respectively. Interestingly, HSC70–1, HSC70–4, and HSC70–5 also showed slight induced expressions in the fat body and/or midgut under thermal stresses. In addition, the expression of HSP70–1 was induced by dichlorvos and phoxim insecticides, while most HSC70 genes were inhibited. The results suggested that stress-inducible forms play more important roles in adaptation to various stresses than HSC70s.
Fabrication of a Hydrogenated Amorphous Silicon Detector in 3-D Geometry and Preliminary Test on Planar Prototypes
Authors: Menichelli Mauro , Bizzarri Marco , Boscardin Maurizio , Caprai Mirco , Caricato Anna Paola , Cirrone Giuseppe Antonio Pablo , Crivellari Michele , Cupparo Ilaria , Cuttone Giacomo , Dunand Silvain , Fanò Livio , Alì Omar Hammad , Ionica Maria , Kanxheri Keida , Large Matthew , Maruccio Giuseppe , Monteduro Anna Grazia , Moscatelli Francesco , Morozzi Arianna , Papi Andrea , Passeri Daniele , Petasecca Marco , Rizzato Silvia , Rossi Alessandro , Scorzoni Andrea , Servoli Leonello , Talamonti Cinzia , Verzellesi Giovanni , Wyrsch Nicolas
Published: October 2021

Hydrogenated amorphous silicon (a-Si:H) can be produced by plasma-enhanced chemical vapor deposition (PECVD) of SiH4 (silane) mixed with hydrogen. The resulting material shows outstanding radiation hardness properties and can be deposited on a wide variety of substrates. Devices employing a-Si:H technologies have been used to detect many different kinds of radiation, namely, minimum ionizing particles (MIPs), X-rays, neutrons, and ions, as well as low-energy protons and alphas. However, the detection of MIPs using planar a-Si:H diodes has proven difficult due to their unsatisfactory S/N ratio arising from a combination of high leakage current, high capacitance, and limited charge collection efficiency (50% at best for a 30 µm planar diode). To overcome these limitations, the 3D-SiAm collaboration proposes employing a 3D detector geometry. The use of vertical electrodes allows for a small collection distance to be maintained while preserving a large detector thickness for charge generation. The depletion voltage in this configuration can be kept below 400 V with a consequent reduction in the leakage current. In this paper, following a detailed description of the fabrication process, the results of the tests performed on the planar p-i-n structures made with ion implantation of the dopants and with carrier selective contacts are illustrated.
Iris Liveness Detection for Biometric Authentication: A Systematic Literature Review and Future Directions
Authors: Khade Smita , Ahirrao Swati , Phansalkar Shraddha , Kotecha Ketan , Gite Shilpa , Thepade Sudeep D.
Published: October 2021

Biometrics is progressively becoming vital due to vulnerabilities of traditional security systems leading to frequent security breaches. Biometrics is an automated device that studies human beings’ physiological and behavioral features for their unique classification. Iris-based authentication offers stronger, unique, and contactless identification of the user. Iris liveness detection (ILD) confronts challenges such as spoofing attacks with contact lenses, replayed video, and print attacks, etc. Many researchers focus on ILD to guard the biometric system from attack. Hence, it is vital to study the prevailing research explicitly associated with the ILD to address how developing technologies can offer resolutions to lessen the evolving threats. An exhaustive survey of papers on the biometric ILD was performed by searching the most applicable digital libraries. Papers were filtered based on the predefined inclusion and exclusion criteria. Thematic analysis was performed for scrutinizing the data extracted from the selected papers. The exhaustive review now outlines the different feature extraction techniques, classifiers, datasets and presents their critical evaluation. Importantly, the study also discusses the projects, research works for detecting the iris spoofing attacks. The work then realizes in the discovery of the research gaps and challenges in the field of ILD. Many works were restricted to handcrafted methods of feature extraction, which are confronted with bigger feature sizes. The study discloses that dep learning based automated ILD techniques shows higher potential than machine learning techniques. Acquiring an ILD dataset that addresses all the common Iris spoofing attacks is also a need of the time. The survey, thus, opens practical challenges in the field of ILD from data collection to liveness detection and encourage future research.
Anomaly Detection and Classification in Predictive Maintenance Tasks with Zero Initial Training
Authors: Morselli Filippo , Bedogni Luca , Mirani Umberto , Fantoni Michele , Galasso Simone
Published: October 2021

The Fourth Industrial Revolution has led to the adoption of novel technologies and methodologies in factories, making these more efficient and productive. Among the new services which are changing industry, there are those based on machine learning algorithms, which enable machines to learn from their past observations and hence possibly forecast future states. Specifically, predictive maintenance represents the opportunity to understand in advance possible machine outages due to broken parts and schedule the necessary maintenance operations. However, in real scenarios predictive maintenance struggles to be adopted due to a multitude of variables and the heavy customization it requires. In this work, we propose a novel framework for predictive maintenance, which is trained online to recognize new issues reported by the operators. Our framework, tested on different scenarios and with a varying number and several kinds of sensors, shows recall levels above 0.85, demonstrating its effectiveness and adaptability.
The European Commission’s Proposal for an Artificial Intelligence Act—A Critical Assessment by Members of the Robotics and AI Law Society (RAILS)
Authors: Ebers Martin , Hoch Veronica R. S. , Rosenkranz Frank , Ruschemeier Hannah , Steinrötter Björn
Published: October 2021

On 21 April 2021, the European Commission presented its long-awaited proposal for a Regulation “laying down harmonized rules on Artificial Intelligence”, the so-called “Artificial Intelligence Act” (AIA). This article takes a critical look at the proposed regulation. After an introduction (1), the paper analyzes the unclear preemptive effect of the AIA and EU competences (2), the scope of application (3), the prohibited uses of Artificial Intelligence (AI) (4), the provisions on high-risk AI systems (5), the obligations of providers and users (6), the requirements for AI systems with limited risks (7), the enforcement system (8), the relationship of the AIA with the existing legal framework (9), and the regulatory gaps (10). The last section draws some final conclusions (11).
Reduction of Elective Radiotherapy Treatment Volume in Definitive Treatment of Locally Advanced Head and Neck Cancer—Comparison of a Prospective Trial with a Revised Simulated Contouring Approach
Authors: Weissmann Thomas , Speer Stefan , Putz Florian , Lettmaier Sebastian , Schubert Philipp , Shariff Maya , Semrau Sabine , Gostian Antoniu-Oreste , Traxdorf Maximilian , Mueller Sarina K. , Eckstein Markus , Hautmann Matthias , von der Grün Jens , Haderlein Marlen , Frey Benjamin , Gaipl Udo S. , Bert Christoph , Iro Heinrich , Fietkau Rainer , Hecht Markus
Published: October 2021

Definitive radiochemotherapy of locally advanced head and neck squamous cell cancer (HNSCC) achieves high locoregional tumor control rates; but is frequently associated with long-term toxicity. A future direction could be a de-escalation strategy focusing on treated volume rather than radiotherapy dose. This analysis evaluates radiotherapy dose and volume parameters of patients treated with a standard contouring approach in a clinical trial context compared with a revised volume-reduced contouring approach. In this case, 30 consecutive patients from the CheckRad-CD8 trial treated at a single study center were included in this analysis. Treatment toxicity and quality of life were assessed at the end of radiotherapy. Standard treatment plans (ST) following state of the art contouring guidelines that were used for patient treatment and volume reduced treatment plans (VRT) according to a revised simulated approach were calculated for each patient. Planning target volumes (PTV) and mean doses to 38 organs-at-risk structures were compared. At the end of radiotherapy patients reported high rates of mucositis; dysphagia and xerostomia. In addition; patient reported quality of life as assessed by the EORTC QLQ-HN35 questionnaire deteriorated. Comparing the two contouring approaches; the elective PTV_56 Gy and the high risk PTV_63 Gy (shrinking field) were significantly smaller in the VRT group. Significant reduction of mean dose to structures of the oral cavity; the larynx as well as part of the swallowing muscles and the submandibular glands was achieved in the simulated VRT-plan. Treatment de-intensification by reduction of the irradiated volume could potentially reduce treatment volume and mean doses to organs at risk. The proposed contouring approach should be studied further in the context of a clinical trial.
Optimal Techniques for EUS-Guided Fine-Needle Aspiration of Pancreatic Solid Masses at Facilities without On-Site Cytopathology: Results from Two Prospective Randomised Trials
Authors: Paik Woo Hyun , Choi Joon Hyuk , Park Yangsoon , Lee Jung Bok , Park Do Hyun
Published: October 2021

Background: EUS-guided fine-needle aspiration (EUS-FNA) has emerged as the primary modality for the cytologic diagnosis of pancreatic solid masses. The aim of this study is to determine whether technical factors including suction (S), non-suction (NS), capillary sampling with stylet slow-pull (CSSS), and the number of needle actuations (to-and-fro needle movements) may affect the accuracy of EUS-FNA for pancreatic solid masses at facilities without on-site cytopathology. Methods: The diagnostic yield of malignancy, blood contamination and cellularity at each sample acquired from EUS-FNA with or without S and different numbers of actuation (10, 15 and 20) were measured (study I). The optimal actuation number was determined and a head-to-head comparison trial between S and CSSS was performed (study II). Results: In study I, significant blood contamination was seen using S with 20 compared with 15 actuations (p = 0.002). Diagnostic yield of malignancy was not significantly different between 10, 15, and 20 actuations with S, whereas it was statistically higher for 15 actuations compared with 10 actuations with NS (p = 0.001). In study II, no difference was noted in diagnostic yield with 15 actuations between S and CSSS (88% vs. 90%, p = 0.74). Conclusions: Increasing actuation in NS resulted in a better diagnostic yield for EUS-FNA without significant blood contamination, whereas increasing actuation in S did not change the diagnostic yield of EUS-FNA while causing significant blood contamination. With 15 actuations, the diagnostic yield was comparable between S and CSSS.
Incident Crohn’s Disease as a Risk Factor for Colorectal Cancer in the First 10 Years after Diagnosis: A Nationwide Population-Based Study
Authors: Kim Hyunil , Kim Ji Hoon , Lee Jung Kuk , Kang Dae Ryong , Kim Su Young , Kim Hyun-Soo , Kim Hee Man
Published: October 2021

We investigated the risk of colorectal cancer (CRC) in patients with Crohn’s disease (CD) using the claims data of the Korean National Health Insurance during 2006–2015. The data of 13,739 and 40,495 individuals with and without CD, respectively, were analyzed. Hazard ratios (HRs) were calculated using multivariate Cox proportional hazard regression tests. CRC developed in 25 patients (0.18%) and 42 patients (0.1%) of the CD and non-CD groups, respectively. The HR of CRC in the CD group was 2.07 (95% confidence interval (CI), 1.25–3.41). The HRs of CRC among men and women were 2.02 (95% CI 1.06–3.87) and 2.10 (95% CI, 0.96–4.62), respectively. The HRs of CRC in the age groups 0–19, 20–39, 40–59, and ≥60 years were 0.07, 4.86, 2.32, and 0.66, respectively. The HR of patients with late-onset CD (≥40 years) was significantly higher than that of those with early-onset CD (<40 years). CD patients were highly likely to develop CRC. Early-onset CD patients were significantly associated with an increased risk of CRC than matched individuals without CD. However, among CD patients, late-onset CD was significantly associated with an increased risk of CRC.
Hodgkin Lymphoma: A Special Microenvironment
Authors: Opinto Giuseppina , Agostinelli Claudio , Ciavarella Sabino , Guarini Attilio , Maiorano Eugenio , Ingravallo Giuseppe
Published: October 2021

Classical Hodgkin’s lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvironment. The cells of microenvironment are essential for growth and survival of the RS/H cells and are recruited through the effect of cytokines/chemokines. We summarize recent advances in gene expression profiling (GEP) analysis applied to study microenvironment component in cHL. We also describe the main therapies that target not only the neoplastic cells but also the cellular components of the background.
Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis
Authors: Zhu Jun , Inomata Takenori , Di Zazzo Antonio , Kitazawa Koji , Okumura Yuichi , Coassin Marco , Surico Pier Luigi , Fujio Kenta , Yanagawa Ai , Miura Maria , Akasaki Yasutsugu , Fujimoto Keiichi , Nagino Ken , Midorikawa-Inomata Akie , Hirosawa Kunihiko , Kuwahara Mizu , Huang Tianxiang , Shokirova Hurramhon , Eguchi Atsuko , Murakami Akira
Published: October 2021

Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival.