bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemanfaatan Media Konkret Untuk Meningkatkan Hasil Belajar IPA Pada Siswa Kelas IV MIN 19 Bireuen Dengan Materi Sumber Daya Alam
Authors: Halim Amar
Published: May 2023

Sumber daya alam merupakan pokok utama dalam kehidupan manusia. Manusia yang dianugerahi ilmu pengetahuan kemudian melakukan pengembangan dan eksplorasi untuk menemukan berbagai sumber daya alam yang tersedia dibumi, dan dimanfaatkan oleh segenap makhluk untuk melangsungkan kehidupan di bumi. Sumber daya yang tersedia dibumi itu dapat di golongkan kepada dua macam berdasarkan sifatnya yaitu sumber daya alam yang dapat diperbaharui dan sumber daya alam yang tidak dapat diperbarui. Lingkungan tempat tinggal manusia adalah salah satu sumber daya alam  yang dapat diolah oleh manusia itu sendiri. Adakalanya manusia cukup melakukan hal-hal yang sederhana dalam mengolah sumber daya alam tersebut dan tak perlu  menunggu waktu yang lama maka akan memperolah hasil yang sudah bisa di manfaatkan. Adapun tujuan penelitian ini adalah untuk meningkatkan pemahaman dan pengetahuan siswa tentang sumber daya alam di lingkungan sekitar. Data ataupun objek dari penelitian ini adalah siswa-siswa kelas IV MIN 19 Bireuen dengan jumlah 20 orang terdiri dari 4 orang siswa perempuan dan 16 orang siswa laki-laki. Metode penelitian yang digunakan adalah kuatitatif. Pada siklus I terlihat bahwa persentase hasil belajar siswa mencapai 37.93%. hal ini menunjukan bahwa siswa belum sepenuhnya mencapai ketuntasan belajar. Sedangkan pada siklus II telah mengalami penigkatan hasil belajar kelas mencapai 86.20%, dan pada siklus III mencapai 96.55%, hal ini menunjukan ada peningkatan rata-rata kelas.
Painting as a Means of Art Therapy for Children – Children with Autism Spectrum Disorder (Case Study in Kaliwungu Kudus State Extraordinary School)
Authors: Sutarjo Johan
Published: May 2023

Painting activities can be used as a means of art therapy for children with Autism Spectrum Disorder at the Kaliwungu Kudus State Extraordinary School. The objectives of this study can specifically be formulated: 1). To find out and explain the potential of painting activities for art therapy for children with Autism Spectrum Disorder and 2). To know and explain the implementation of art therapy through painting activities for children with Autism Spectrum Disorder. The benefits of research are generally expected to provide information & input both theoretical and empirical to relevant parties about alternative treatments for the healing process of autistic children through art therapy. In this study, it has used a descriptive study, namely research that has the purpose of describing a situation. This research approach uses qualitative because it examines information, information, & symptoms from a result of the observation process during this study regarding the matter of "Painting as a Means of Art Therapy for Children with Autism Spectrum Disorder (Case Study in The Extraordinary School of Kaliwungu Kudus State)". This research has also been centered on a problem of planning, organizing system, implementation in research, implemented at the Kaliwungu Kudus State Extraordinary School. The research objective focuses on a research problem. The research location is at the Kaliwungu Kudus State Extraordinary School. Research data can be collected with controlled observation techniques, interviews, & documentation.  The results of this study show that the type of painting activity that is suitable for children with Autism Spectrum Disorder is painting free expression.
SELF-RELIANCE ECONOMIC SYSTEM BASED ON WAQF AT ISLAMIC BOARDING SCHOOL DARUSSALAM GONTOR INDONESIA
Authors: Ahmad Fanani  , Rahmad Hakim
Published: May 2023

This study aims to determine the concept of self-reliance of economics based on waqf in Pondok Modern Darussalam Gontor Indonesia and the impact of it in the development of education and financial institutions. This research is descriptive qualitative, the method of collecting data using documentation, whereas the method of data analysis using content analysis. The result of this study indicate that concept of self-reliance economic system based on waqf in Islamic Boarding School Darussalam Gontor begun from establishing of Waqf Enlargement Institution, known as YPPWPM, whose responsible is to develop, manage, and enlarge waqf asset through waqf business or social enterprise done by teachers and students under the supervision of headmaster, and the impact of waqf business towards education development is known from the cheapest tuition fees of the school and the meals for students, and also the scholarship for teachers while they study in higher education.
رسائلُ البيَّايتّ إىل اإلمام الشَّافعي:ّ دراسة حتليليَّة
Authors: مصطفى حممد رزق السواحلي
Published: May 2023

حاول بعضُ الشُّعراءِ العربِ يف القرن العشرين حتديثَ الشعر العريبّ شكلًا ومضمونًا،فظهرتْ من حيث الشَّكل أمناطٌ جديدةٌ لعلَّ أبرزَها الشِّعرُ احلُر،ُُّ أو قصيدةُ التَّفعيلة،وجتلَّتْ من حيث املضمون آليَّاتٌ جديدةٌ للتعبري عن الفكرة، مثل: الرَّمز واألسطورةوالقناع واملفارقة... وغريها. وقد كان للشَّاعر العراقيِّ عبد الوهاب البيَّايتّ)5999-5943م( يدٌ طُوىل يف هذا التحديث الشَّعريِّ نظريًّا وتطبيقيًّا، حيثأمعن يف استدعاء الشخصيَّات التارلخيَّة بكلِّ أمناطها، واختذ منها قناعًا ليعبِّر من ورائهعن جتاربه الذاتيَّة، ويعاجلَ من خَلْف سِتاره عذاباتِ اإلنسانِ يف العصر احلديث. ومنبني القصائد اليت توارى فيها خلف شخصيَّة إسالميَّة تارلخيَّة قصيدته: رسائل إىلاإلمام الشَّافعي،ّ اليت نشرها عام 5973م. وحياولُ هذا البحثُ الوقوفَ على جتربتهيف استدعاء شخصيَّة اإلمام الشَّافعي،ّ وذلك لبيان مدى توفيقه يف اختيار هذهالشخصيَّة اليت ال نعرف شاعرًا آخر قام باختاذها قناعًا لتجربته الشعريَّة، ومدىإجادته يف التعبري عن فكرته اليت توخَّت القصيدةُ إيصاهلا إىل الـمُتلقِّي، وذلك منخالل املنهج الوصفي التحليلي،ّ وقد انتهى البحث إىل عدد من النتائج أمهُّها: أنَّهذه القصيدة مِنْ أضعفِ قصائد البيَّايتّ اليت وظَّف فيها تقنية القناع، واليت استدعىفيها شخصيَّة تراثيَّة، حيث وقع يف عدَّةِ مزالق فنيَّة أبرزها: بُعْدُ التأويل، فالفكرةالرئيسة لقصيدة البيَّايتّ هي قضيَّة الضياع والشرود على املستويني العامِّ واخلاص،ِّوهي مسألةٌ ال جند هلا صدًى يف حياة اإلمام الشَّافعيّ خاصَّة،ً أو يف عصره عامَّة،ًواإلسرافُ يف تكديس شخصيَّات ال عالقة هلا باملوضوع، وسطحيَّةُ القناع، حيث م يأخذْ من شخصيَّة اإلمام الشَّافعيّ فيما نعتقد سوى العنوان فحسب، والغموضُالشديد الذي جيعل من قصيدة البيَّايتّ املدروسة حتدِّيًا أمام غري املتمرِّسني بقراءة الشعرالعريبّ احلديث
تعريف اإلحلاد: دراسة إبستيمولوجية
Authors: أمحد أحيد بن حاج أمينور  , أنيس مالك طه
Published: May 2023

يهدف هذا البحث يف بيان مفهوم اإلحلاد وذلك من منظورين خمتلفني، مها: منظورإسالمي ومنظور غريب. وذلك باستقراء مفاهيم كلمة اإلحلاد املقررة م حتليلها منحيث استعماالهتا يف سياقات متعددة عند علماء املسلمني وفالسفة الغربيني مبنهجيةاستقرائية حتليلية ومقارنة. وذلك ألن اصطالح اإلحلاد له عدة معان حسب األنظاراملختلفة ويتغري معناه بتغري السياق، وذلك راجع إىل أصل وضعهم هذه الكلمة،وثقافتهما املختلفة. وهذا أمر مهم حيث إن فكرة اإلحلاد هي فكرة تدرّس لدىالباحثني املسلمني، فينبغي تصورها تصورا صحيحا كي يصل الباحث إىل نتيجةموفقة خالية من االعتراضات. ويف موضوع اإلحلاد، هناك ثقافتان جيد الباحثون عنهمتاعه فيهما مها الثقافة اإلسالمية والثقافة الغربية. سيشتمل هذا البحث على مفهومكلمة اإلحلاد عنداملسلمني من حيث أصل اللغة واستعماالت العلماء، ومفهوم كلمةاإلحلاد أي )Atheism )عند فالسفة الغرب من حيث أصل اللغة والفلسفة وأنواعهاملختلفة لديهم، وبعد ذلك جاء دور تقرير نسبة هذه املعاين بعضها بعضا، أي هلهناك مثال التداخل بينها أو التباين التام وغريمها من تلك املفاهيم املختلفة. يكشفهذا البحث بأن للفظ اإلحلاد إطالقان خمتلفان على حسب املنظورين، وبينهما نسبخمتلفة باعتبارات خمتلفة.
Development and its Actors: The Milieu of Islamic-based Development
Authors: Shereeza binti Mohamed Saniff
Published: May 2023

This article looks at the evolution of Islamic-based development as a field of study and then examines the concept of Islamic-based development actor (or IbD Actor). The emphasis of this article is on the importance of humans as the actors of development. It is the humans, as the central figure that defines which development paradigm is to transpire as development occurs at the hands of humans. However the differing development paradigms between the Islamic-based to that of conventional strike at the very core – the philosophical underpinnings. The conventional development paradigm influences even the Muslim countries. The dominance of conventional development has even overshadowed the concept of Islamic economics, one facet of Islamic development. With such antagonism natural conflict arises. This results in the achievement of the ultimate goals of the development paradigms to differ completely. Hence the dilemma to man as the actor of any development process who need to decide which development goal that is needed to be achieved foremost. In seeking out the required answers for this article, library research is mainly used to obtain the various concepts and assessment applied to in this article with textual analysis carried out. The article suggests that for man as actor of development to be detangled from the dilemma, only a truly Islamic-based development paradigm can be seen as the saviour. However for a truly Islamic-based development to transpire requires foremost man to be the IbD Actor.
Orientalists Attack Against Prophetic Traditions: Awareness and Wake up Call
Authors: Ahamad Faosiy Ogunbado  , Ishaaq El-Mubarak
Published: May 2023

Orientalists had been working seriously towards the demolition of the second primary source of Islamic law where most Islamic proofs are derived. Given the strong links between the unnecessary allegations against some Prophetic traditions and irrelevant arguments about the compilation of Sunnah clearly proves their sceptics around the entire words of the Holy Prophet Muhammad (Peace be upon him). With this regard, there is a pressing need to replace some assumptions and misconceptions regarding these standpoints through academic approaches, so that Muslims will not be discouraged and misguided away from the real sources of Islamic law. For this sake, this study seeks to establish a number of facts which can eliminate the doubtful mind Muslims might have assumed from the wrong perceptions this group had created around the compilation and validity of Sunnah. In addition to that, this article aspires to reveal Orientalist deceiving facts in swapping false theories into realities in Islam. It also tends to evaluate the group’s plan and see whether they really wish to support Islam with these agendas or demolish it. Moreover, do they have any sincere intention and objections in probing the authenticity of Sunnah? In achieving these goals, descriptive method is used to pinpoint techniques and features of this set of group. While analytical approach is adopted with the aim of acknowledging their strategies. Apparently, findings assert that Orientalists doesn’t have any reasonable justification in challenging the validity of the Prophetic tradition. Asides that, results show that this set of people are merely using this ideology to divert Muslims’ attention from the faithful belief they have for the Prophet and his traditions.
Halal and The Risk Society
Authors: Yoshinori Sumimura
Published: May 2023

In the process of modernization, many Muslims have come to consume industrially produced products. According to Beck, this is a process that unwittingly creates risks, and risks related to Halal are included in those risks. Discussion on Halal is about cultural risks, which arise later than environmental and health risks as Beck brought up. This is because the Muslim population entered the process of modernization later than in developed countries such as Europe and the United States in general. The base of industrial technologies related to food have been established without any awareness of Halal and have had to interpret, create regulations, build systems, and make choices for Halal. Furthermore, in the process of creating new technologies, the risk of violating Halal is further increased. Surrounded by shubhah, Muslims are having to assume responsibility for halal and make choices amid uncertainty in modern society. As consumers, Muslims will have to confront this situation through transnational solidarity and by joining the risks of halal with other risks also created by modernity. Science is a cog in the wheel of industrial progress. In order to address the issue of Halal in a risky society, it is essential to provide information and risk communication to Muslim consumers, in addition to providing alternative technologies suitable for Halal.
Maqasid-Based Bioprospecting; The Case of Agarwood in The Halalan Toyyiban Product Development
Authors: Yumi Zuhanis Has-Yun Hashim  , Nurhusna Samsudin  , Anis Najiha Ahmad  , Mohd Aizat Jamaludin
Published: May 2023

This paper aims to explore the concepts and values of Maqasid al-shariah in bioprospecting. The activities of bioprospecting are not new and have been well established in various industries ranging from pharmaceuticals, and manufacturing to biomining and nanotechnology. Bioprospecting is the discovery of biodiversity for new biological resources of social and economic value. Although the premises of bioprospecting are known to be closely tied to sustainability and conservation of biodiversity, to the best of our knowledge, there are no discussions on bioprospecting from the perspective of Maqasid. This paper explores this relationship with a focus on agarwood, a non-timber forest product (NTFP) that has been traded for centuries. Over the years, agarwood has been subjected to bioprospecting and is increasingly being used as a material in the development of halalan toyyiban products.
Halal Food Producer as An Alternative Employment Job for Halal Science Graduates in Brunei Darussalam
Authors: Nurdeng Deuraseh  , Norkhairiah Hashim  , Raihana Mohd Raffi  , Nurul Jannahtul Hanani Rosli
Published: May 2023

Employment has always been a source of worry among university graduates. The unemployment rate is possibly the most well-known labour market indicator and certainly one of the most regularly mentioned by the media in many countries, as it is thought to best reflect the lack of employment at the national level. In nations that collect data on the labour force, it gives the broadest measure of the labour market situation, along with the employment to population. A quantitative survey was conducted to scrutinize how halal science graduates could get themselves employed in the halal food sector. The survey questionnaires were designed and targeted at those who venture into the halal food business. The study resulted that the halal food producer may gain the lowest and highest monthly income of less than five hundred and more than five thousand respectively. Thus, with the good marketability of halal food and resources, there is a vast opportunity for these halal graduates to venture into businesses selling halal food as they can implement all knowledge; they gained in their halal science studies at the University.
Practices of Halalan Thayyiban Aspect in Japanese Restaurants in Brunei Darussalam
Authors: Nurul Farhanah Hamdan  , Norkhairiah Hashim
Published: May 2023

The halalan thayyiban concept has been mentioned in al-Quran and sunnah. The popularisation of Japanese cuisine is a global phenomenon and Brunei Darussalam is not an exception. With the growing number of non-Islamic food products dominating the halal food industry, the status of halal food has become uncertain and controversial. The Brunei Government has emphasised the importance of Brunei restaurants complying with the requirements of halal eligibility and shariah law. Therefore, the need for Japanese restaurant management to comply with the halal norm is inevitable. This study has been conducted in an attempt to explore halalan thayyiban practices that are being implemented in Japanese Restaurants in Brunei Darussalam. Data was collected from six participants who were involved in semi-structured interviews. The major findings have shown that respondents were excellent in practising halālan thayyiban in terms of healthy food, food safety, and hygiene in Japanese restaurants. These findings are very important and hopefully can be used as a guide to restaurant employees in other ethnic restaurants and also greatly benefit Muslim and non-Muslim readers who consume halal food.
UNDERSTANDING PURCHASE DECISION BEHAVIOUR OF MUSLIM RESIDENTS IN JAPAN: A QUALITATIVE SHADOWING METHODOLOGY
Authors: Mohd Raffi Raihana , Johari Nabilah , Yosuke Shimazono , Yoshinori Sumimura
Published: May 2023

Japan has been a destination of choice for Muslims to travel either for work, leisure, or study. While being a popular tourist spot, there are several concerns and challenges experienced by Muslims residing in Japan. Therefore, the purpose of this study is to obtain a complete understanding, in-depth information, and a need to identify the concerns and difficulties faced by Muslim consumers in Japan in accessing halal food. In addition to that, this study also looks into factors influencing Muslim consumers' behavior when buying foods in supermarkets. For this study, the methodology used qualitative shadowing methodology, whereby short observations and interviews took place for further clarity of the participants' backgrounds and purchasing decisions. Two participants have been observed during their trip to supermarkets. The finding shows that Muslim residents’ accessibility to halal food is relatively difficult in non-tourist areas.
La constitution de l’entreprise sous forme de société commerciale est-elle compatible avec la RSE ?
Authors: LANDIER Hubert
Published: May 2023

La remise en question du modèle de croissance en vigueur induite par ses multiples externalités a permis, dans une large mesure, d’inscrire la problématique de la RSE au centre des débats. Si celle-ci traduit l’intégration des principes du Développement Durable par les entreprises, son fondement dans le contexte de l’entreprise commerciale reste encore à démontrer. Qu’il s’agisse de l’entreprise commerciale ou plus généralement de la société de capitaux, l’objectif est de valoriser au mieux l’investissement réalisé par les actionnaires de manière à veiller à leurs intérêts. Dans ce sens, la RSE ne peut constituer un objectif premier et elle ne peut être envisagée que pour autant qu’elle contribue à la performance actionnariale de l’entreprise.
Les soubassements juridiques du DD et de la RSE – Un des leviers institutionnels incontournables pour la promotion de ces concepts au Maroc
Authors: BOUKIL Aouatif , Messaoudi Abderrahmane
Published: May 2023

Deux méta ingénieries sociales intègrent la société marocaine et imposent une réforme globale, en l’occurrence le développement durable et la RSE. L’objectif primordial de cet article est de mener une réflexion autour des mesures prises par l’Etat marocain pour promouvoir ces deux concepts et de se focaliser de manière critique sur les leviers juridiques dédiés à leur institutionnalisation. Ces concepts reconnus à l’échelle mondiale suscitent l’intérêt des acteurs socio-économiques marocains et les incitent à s’y engager afin de s’adapter aux exigences du développement à l’international.
Les contraintes de mise en valeur touristique du Sahara et des oasis de Douz (Sud-ouest tunisien)
Authors: ELFALEH IMED
Published: May 2023

L’offre touristique tunisienne a longtemps été standardisée et axée essentiellement sur un produit balnéaire. Des efforts d’institutionnels et d’acteurs de tourisme ont été déployés pour diversifier cette offre, notamment en essayant d’introduire un tourisme alternatif tel que « le saharien » dont les potentialités géographiques, touristiques et socioéconomiques semblent être évidentes pour le développement local. Cependant, le Sahara et les oasis de Douz, le portail du désert, subissent depuis les années 1980 les aléas de la mise en valeur touristique contrainte par plusieurs problèmes assignés à la conjoncture économique, sécuritaire et touristique internationale et à la structure du tourisme tunisien, en général et saharien en particulier. L’exploitation des oasis et du Sahara de Douz comme produit touristique n’était pas suffisamment bénéfique pour la population locale qui demeure exclue de la sphère touristique. Cette exploitation a dépassé le caractère paysager pour concerner leur mise en valeur économique, sociale et écologique. La conjoncture actuelle du tourisme tunisien, le saharien, en particulier après 2011 a accentué la crise de cette mise en valeur. Plusieurs zones oasiennes et sahariennes ont été délaissées et marginalisées après plusieurs années d’exploitation excessive. La problématique de ce travail sera axée sur le repérage de différentes mises en valeur touristiques des sites oasiens et sahariens dans cette zone. Elle sera axée également sur les contraintes de cette exploitation touristique.
Investigación cualitativa y mixta en derecho. tipología y la aplicación del metaanálisis cualitativo
Authors: Mendizábal Anticona Walter Jorge , Huanca Frías José Oscar , Huanca Frías Rene Eduardo , Quispe Ticona Ingrid Liz
Published: May 2023

El objetivo del estudio: Determinar la naturaleza epistemológica de la investigación cualitativa y mixta en el derecho, resaltando su tipología y la aplicación del metaanálisis cualitativo. Se abordó el diseño de investigación cualitativa y mixta en derecho, centrándose en la importancia de la integración de diferentes fuentes de datos y enfoques metodológicos para obtener una imagen más completa y precisa del fenómeno en cuestión. Se discuten los diferentes tipos de diseño de investigación cualitativa y mixta, así como los métodos de recolección de datos más comunes en el campo del derecho; además, se presenta el metaanálisis como una herramienta útil para la síntesis y análisis de datos en la investigación jurídica. Se destaca que el metaanálisis no se limita solo al enfoque estadístico, sino que también se puede realizar un metaanálisis cualitativo utilizando un enfoque de análisis documental propositivo. Se destaca la importancia de la planificación cuidadosa y la reflexividad en la realización de un diseño de investigación cualitativa y mixta en derecho, así como la necesidad de una comunicación clara y precisa de los resultados para una aplicación efectiva de los estudios con una clara tendencia a salir de los formulismos y requiebros solemnes que distraen la característica esencial en las ciencias jurídicas: La hermenéutica y dogmática dinámica de las investigaciones. La metodología es básica, propositiva, explicativa. Se concluye que, las investigaciones cualitativas y mixtas son amoldables significativamente en la ciencia del Derecho y concurrentemente en otras disciplinas y que debe primar la libertad de formalidades recurriendo a herramientas como el metaanálisis cualitativo que bien se adapta al Derecho en una aplicabilidad de datos hermenéuticos jurídicos lejos de la cuantificación pura.
Autocuidado frente a las enfermedades de transmisión sexual en universitarios de México
Authors: García Lirios Cruz
Published: May 2023

Los estudios de la adhesión al tratamiento han explicado las trayectorias de relaciones entre factores determinantes a partir de modelos teóricos relativos a la acción razonada y el comportamiento planificado, aunque el énfasis en la cognición supone que la adhesión es un proyecto subjetivo más que grupal, el presente trabajo se propuso indagar el efecto de las normas y los valores sobre las creencias, actitudes e intenciones como variables antecedentes de la adhesión al tratamiento. Se realizó un estudio exploratorio, transversal, psicométrico y correlacional con una muestra de 258 estudiantes, seleccionados por su participación en prácticas profesionales y servicio social en el área de la salud y prevención de riesgos. Los resultados muestran que la interrelación entre los factores culturales –normas, valores, creencias– con los factores cognitivos –actitudes, conocimientos, percepciones, intenciones– determinan la adhesión al tratamiento, pero su influencia supone la inclusión de otros factores explicativos del umbral socioeconómico y sociodemográfico determinante de la adhesión al tratamiento en grupos de edad y contextos económicos.
Atención centrada en la persona en residencias para demencia: influencia de variables organizacionales y del staff. Una revisión narrativa
Authors: Tirigay Romina , Cossini Florencia , Antenore Marcela , Rubinstein Wanda
Published: May 2023

La presente revisión tiene como objetivo principal estudiar cuáles son las variables, tanto personales como organizacionales, que influyen en la perspectiva del personal de cuidados sobre el abordaje ACP de residencias de larga estadía para demencia. Se realizó una revisión narrativa basada en ocho artículos relevantes identificados a través de PubMed y NICE publicados entre el 2000 y el 2020 usando las palabras clave “Atención centrada en la persona”, “demencia”, “residencias para personas con demencia de larga estadía”, “adultos mayores con demencia institucionalizados”, “personal de atención directa” “variables del personal de atención directa” y “variables institucionales”. Los hallazgos de la revisión actual muestran que existe influencia tanto de ciertas variables personales (nivel de escolaridad e índice de burnout) como de variables institucionales (clima laboral, ambiente físico, trabajo grupal y apoyo de los líderes) siendo estas últimas las que ejercen la mayor influencia. La importancia de dicha influencia revela hacia dónde deberían estar dirigidos los esfuerzos institucionales a la hora de aplicar el paradigma de atención centrada en la persona.
Administración telemática del Protocolo Unificado para el tratamiento transdiagnóstico de los trastornos emocionales en adolescentes (tUP-A): un estudio de casos
Authors: Espinosa Lorenzo Victoria , García-Escalera Julia , Arnáez Sandra , Valiente Rosa M. , Sandín Bonifacio , Schmitt Julia C. , Chorot Paloma
Published: May 2023

El objetivo de este estudio fue proporcionar evidencia preliminar, de tipo cualitativo y cuantitativo, sobre la utilidad clínica del UP-A aplicado de forma telemática (tUP-A). Tres adolescentes diagnosticados de trastornos emocionales recibieron el tUP-A a través de sesiones semanales individuales por videollamada. Se examinaron los cambios en diversas variables cuantitativas y cualitativas actuando como informantes los adolescentes, los padres y los propios terapeutas. Los resultados basados en los momentos pre-/post-tratamiento y seguimiento (a los 3 y 6 meses) muestran una importante reducción de la sintomatología ansioso-depresiva en los tres adolescentes de acuerdo con las diferentes fuentes de información. Se discuten las implicaciones de administrar telemáticamente el UP-A para mejorar el acceso a la terapia de los trastornos emocionales basada en la evidencia en población adolescente.
Variables relacionadas con el abandono terapéutico en una adaptación grupal del Protocolo Unificado para el tratamiento transdiagnóstico de los trastornos emocionales. Un estudio preliminar
Authors: Ayuso Bartol Antonio , Melero Ventola Alejandra Rebeca , Arruebarrena Aitor Vicente , Wöbbeking Sánchez Marina , Jiménez Gómez Laura , Gómez Martinez M. Ángeles
Published: May 2023

Debido al elevado número de personas que solicitan ayuda psicológica y a la escasez de recursos profesionales de los que disponen muchos servicios, se hace necesario fomentar la puesta en marcha de modalidades terapéuticas que optimicen dichos recursos; una alternativa prometedora es la adaptación grupal del protocolo unificado de Barlow para el abordaje de los trastornos emocionales (Barlow et al., 2018). No obstante, se precisa identificar qué pacientes pueden beneficiarse con más probabilidades de éxito de este protocolo grupal y qué variables caracterizan a los pacientes con mayor riesgo de abandono en este tipo de intervención. El presente estudio se ha realizado sobre una muestra total de 54 personas que iniciaron una adaptación grupal de dicho protocolo, en el Servicio de Asistencia Psicológica de la Universidad Pontificia de Salamanca. Se ha comparado un grupo de pacientes que completan el tratamiento (n= 37) con un grupo que abandona en algún momento el mismo (n=17). Se tomaron medidas de ansiedad, depresión, variables de personalidad, calidad de vida, interferencia y autocompasión. Los resultados indican la presencia de diferencias estadísticamente significativas en los síntomas de ansiedad y en el nivel de interferencia del problema en la vida diaria siendo éstos más severos en el grupo que abandona el tratamiento; los pacientes que completan el tratamiento puntúan significativamente más alto en la variable humanidad compartida, implicada en los procesos de empatía y pertenencia al grupo; asimismo, se observan diferencias en el límite de la significación estadística, en las variables depresión y calidad de vida, siendo los pacientes del grupo que abandona el tratamiento, los que obtienen puntuaciones más elevadas en depresión y más bajas en calidad de vida. Estos resultados preliminares señalan algunas características para identificar, en la evaluación inicial, a los posibles beneficiarios de este formato y optimizar las alternativas terapéuticas ofrecidas.
Aplicación grupal del protocolo unificado para el tratamiento transdiagnóstico de los trastornos emocionales en una muestra universitaria
Authors: Rodríguez-Mora Álvaro , Del Río Francisco Javier , Mallat Israel , Gemar Elisabeth , Barrilado Laura , Fernández Antonio , Hervías Federico
Published: May 2023

Actualmente son pocos los estudios que avalan la eficacia del Protocolo Unificado (PU) para el tratamiento transdiagnóstico de los trastornos emocionales en muestras universitarias. El objetivo de este trabajo ha sido evaluar la validez del PU en formato grupal, en modalidad online y presencial, en alumnado universitario. La muestra estuvo compuesta por 35 participantes que demandaron asistencia en el Servicio de Atención Psicológica (SAP) de la universidad de Cádiz. Se administraron como instrumentos de evaluación: NEO-FFI; STAI; CORE-OM; SCL-90-R; PANAS y BEAQ; además de un cuestionario ad hoc. La intervención se compuso de la aplicación de 12 sesiones del PU en grupos de 8-10 participantes, durante 90 minutos. Los resultados mostraron una mejora en la gestión emocional de los participantes. Se redujo la sintomatología ansiosa y depresiva. Mejoró el bienestar subjetivo y funcionamiento del alumnado. Asimismo, el PU resulto eficaz como estrategia de afrontamiento ante la experimentación de emociones negativas reduciendo la evitación experencial. En relación al formato de aplicación, tanto el formato online como presencial resulto ser eficaz para mejorar la sintomatología presente. Por tanto, el PU parece mostrar su utilidad clínica en el abordaje de los trastornos emocionales en esta población tanto de forma online como presencial.
Association between occurrence of multiple white and flat elevated gastric lesions and oral proton pump inhibitor intake
Authors: Hasegawa Rino , Yao Kenshi , Kanemitsu Takao , Arima Hisatomi , Hirase Takayuki , Hiratsuka Yuuya , Takeda Kazuhiro , Imamura Kentaro , Ohtsu Kensei , Ono Yoichiro , Miyaoka Masaki , Hisabe Takashi , Ueki Toshiharu , Tanabe Hiroshi , Ohta Atsuko , Nimura Satoshi
Published: May 2023

Background/Aims: Multiple white and flat elevated lesions (MWFL) that develop from the gastric corpus to the fornix may be strongly associated with oral antacid intake. Therefore, this study aimed to determine the association between the occurrence of MWFL and oral proton pump inhibitor (PPI) intake and clarify the endoscopic and clinicopathological characteristics of MWFL.Methods: The study included 163 patients. The history of oral drug intake was collected, and serum gastrin levels and anti-Helicobacter pylori immunoglobulin G antibody titers were measured. Upper gastrointestinal endoscopy was performed. The primary study endpoint was the association between MWFL and oral PPI intake.Results: In the univariate analyses, MWFL were observed in 35 (49.3%) of 71 patients who received oral PPIs and 10 (10.9%) of 92 patients who did not receive oral PPIs. The occurrence of MWFL was significantly higher among patients who received PPIs than in those who did not (p<0.001). Moreover, the occurrence of MWFL was significantly higher in patients with hypergastrinemia (p=0.005). In the multivariate analyses, oral PPI intake was the only significant independent factor associated with the presence of MWFL (p=0.001; odds ratio, 5.78; 95% confidence interval, 2.06–16.2).Conclusions: Our findings suggest that oral PPI intake is associated with the presence of MWFL (UMINCTR 000030144).
Mandatory reporting obligations within the context of health research: Grappling with some of the ethical-legal complexities
Authors: Strode A , Badul C
Published: May 2023

Mandatory reporting of various forms of abuse, from violence to corruption, is an attempt by the state to intervene in circumstances where there is a public or a private interest that ought to be protected. This intrusion of the state into what is often a very personal space, such as the home, is largely justified on the basis of the need to provide protection to prevent further harm, and in services to vulnerable populations such as children, the disabled or the elderly. In some instances, researchers and other members of the study team may encounter reportable information requiring the consideration of mandatory reporting in the design, implementation and review of health research. This is not simple. There are complex and competing interests at play, particularly as there are differing approaches in law and ethical guidelines. This article aims to describe the mandatory reporting obligations in South African law, discussing the ways in which these provisions apply within the context of health research, and to propose some factors that could be used to determine whether it is ethical or not to report information.
Robotic Process Automation in Small Enterprises: An Investigation into Application Potential
Authors:   University of Rostock, Albert-Einstein-Str. 22, 18059 Rostock, Germany, Erdmann Sven , Sandkuhl Kurt ,   University of Rostock, Albert-Einstein-Str. 22, 18059 Rostock, Germany,   Jönköping University, Box 1026, 55111 Jönköping, Sweden
Published: May 2023

Substantial application potential in enterprises is commonly attributed to Robotic Process Automation (RPA). This potential encompasses automation of routine tasks, improvement of data quality, improvement of process stability, or reduction of monotonous tasks. However, our observation from projects with enterprises is that this potential is visible in bigger companies, but not so obvious in small and medium-sized enterprises (SMEs). SMEs often show a lower readiness to invest time and resources in new technologies and, thus, hesitate to explore new technology applications unless they see a clear business case. This article investigates the application potential of RPA in SMEs by trying to identify typical application scenarios with potentially high benefits that SMEs should focus on. The application potential is primarily addressed from a qualitative perspective, i.e., the aim is not to quantify the potential but to qualify the application fields. The contributions of this article are (1) a structured literature review of the state of RPA use in SMEs, (2) RPA application scenarios visible in the literature and functionality of RPA platforms to support these scenarios, and (3) experiences from implementing three SME-focused use cases with off-the-shelf RPA tools and a concluding evaluation by experts.
Unrestricted Tribonacci and Tribonacci–Lucas quaternions
Authors:   Kırıkkale University, Kızılaslan Gonca , Karabulut Leyla ,   Kırıkkale University
Published: May 2023

We define a generalization of Tribonacci and Tribonacci–Lucas quaternions with arbitrary Tribonacci numbers and Tribonacci–Lucas numbers coefficients, respectively. We get generating functions and Binet’s formulas for these quaternions. Furthermore, several sum formulas and a matrix representation are obtained.
Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response
Authors: Garde Rania , Singh Abhyudai , Ali Asif , Pincus David
Published: May 2023

The heat shock response (HSR) controls expression of molecular chaperones to maintain protein homeostasis. Previously, we proposed a feedback loop model of the HSR in which heat-denatured proteins sequester the chaperone Hsp70 to activate the HSR, and subsequent induction of Hsp70 deactivates the HSR (Krakowiak et al., 2018; Zheng et al., 2016). However, recent work has implicated newly synthesized proteins (NSPs) – rather than unfolded mature proteins – and the Hsp70 co-chaperone Sis1 in HSR regulation, yet their contributions to HSR dynamics have not been determined. Here, we generate a new mathematical model that incorporates NSPs and Sis1 into the HSR activation mechanism, and we perform genetic decoupling and pulse-labeling experiments to demonstrate that Sis1 induction is dispensable for HSR deactivation. Rather than providing negative feedback to the HSR, transcriptional regulation of Sis1 by Hsf1 promotes fitness by coordinating stress granules and carbon metabolism. These results support an overall model in which NSPs signal the HSR by sequestering Sis1 and Hsp70, while induction of Hsp70 – but not Sis1 – attenuates the response.
Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes
Authors: Zemel Benjamin M , Nevue Alexander A , Tavares Leonardo ES , Dagostin Andre , Lovell Peter V , Jin Dezhe Z , Mello Claudio V , von Gersdorff Henrique
Published: May 2023

Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels involved, we conducted a thorough study of the excitability of upper motor neurons controlling somatic motor function in the zebra finch. We found that robustus arcopallialis projection neurons (RAPNs), key command neurons for song production, exhibit ultranarrow spikes and higher firing rates compared to neurons controlling non-vocal somatic motor functions (dorsal intermediate arcopallium [AId] neurons). Pharmacological and molecular data indicate that this striking difference is associated with the higher expression in RAPNs of high threshold, fast-activating voltage-gated Kv3 channels, that likely contain Kv3.1 (KCNC1) subunits. The spike waveform and Kv3.1 expression in RAPNs mirror properties of Betz cells, specialized upper motor neurons involved in fine digit control in humans and other primates but absent in rodents. Our study thus provides evidence that songbirds and primates have convergently evolved the use of Kv3.1 to ensure precise, rapid AP firing in upper motor neurons controlling fast and complex motor skills.
Imaging microglia surveillance during sleep-wake cycles in freely behaving mice
Authors: Gu Xiaochun , Zhao Zhong , Chen Xueli , Zhang Lifeng , Fang Huaqiang , Zhao Ting , Ju Shenghong , Gao Weizheng , Qian Xiaoyu , Wang Xianhua , Zhang Jue , Cheng Heping
Published: May 2023

Microglia surveillance manifests itself as dynamic changes in cell morphology and functional remodeling. Whether and how microglia surveillance is coupled to brain state switches during natural sleep-wake cycles remains unclear. To address this question, we used miniature two-photon microscopy (mTPM) to acquire time-lapse high-resolution microglia images of the somatosensory cortex, along with EEG/EMG recordings and behavioral video, in freely-behaving mice. We uncovered fast and robust brain state-dependent changes in microglia surveillance, occurring in parallel with sleep dynamics and early-onset phagocytic microglial contraction during sleep deprivation stress. We also detected local norepinephrine fluctuation occurring in a sleep state-dependent manner. We showed that the locus coeruleus-norepinephrine system, which is crucial to sleep homeostasis, is required for both sleep state-dependent and stress-induced microglial responses and β2-adrenergic receptor signaling plays a significant role in this process. These results provide direct evidence that microglial surveillance is exquisitely tuned to signals and stressors that regulate sleep dynamics and homeostasis so as to adjust its varied roles to complement those of neurons in the brain. In vivo imaging with mTPM in freely behaving animals, as demonstrated here, opens a new avenue for future investigation of microglia dynamics and sleep biology in freely behaving animals.
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers
Authors: Heindorf Matthias , Keller Georg B
Published: May 2023

Psychosis is characterized by a diminished ability of the brain to distinguish externally driven activity patterns from self-generated activity patterns. Antipsychotic drugs are a class of small molecules with relatively broad binding affinity for a variety of neuromodulator receptors that, in humans, can prevent or ameliorate psychosis. How these drugs influence the function of cortical circuits, and in particular their ability to distinguish between externally and self-generated activity patterns, is still largely unclear. To have experimental control over self-generated sensory feedback, we used a virtual reality environment in which the coupling between movement and visual feedback can be altered. We then used widefield calcium imaging to determine the cell type-specific functional effects of antipsychotic drugs in mouse dorsal cortex under different conditions of visuomotor coupling. By comparing cell type-specific activation patterns between locomotion onsets that were experimentally coupled to self-generated visual feedback and locomotion onsets that were not coupled, we show that deep cortical layers were differentially activated in these two conditions. We then show that the antipsychotic drug clozapine disrupted visuomotor integration at locomotion onsets also primarily in deep cortical layers. Given that one of the key components of visuomotor integration in cortex is long-range cortico-cortical connections, we tested whether the effect of clozapine was detectable in the correlation structure of activity patterns across dorsal cortex. We found that clozapine as well as two other antipsychotic drugs, aripiprazole and haloperidol, resulted in a strong reduction in correlations of layer 5 activity between cortical areas and impaired the spread of visuomotor prediction errors generated in visual cortex. Our results are consistent with the interpretation that a major functional effect of antipsychotic drugs is a selective alteration of long-range layer 5-mediated communication.
Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
Authors: García-Martínez José Manuel , Chocarro-Calvo Ana , Martínez-Useros Javier , Fernández-Aceñero María Jesús , Fiuza M Carmen , Cáceres-Rentero José , De la Vieja Antonio , Barbáchano Antonio , Muñoz Alberto , Larriba María Jesús , García-Jiménez Custodia
Published: May 2023

Posttranslational modifications of epigenetic modifiers provide a flexible and timely mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an NAD+-dependent epigenetic modifier whose activity is classically associated with healthy aging and longevity, but its function in cancer is not well understood. Here, we reveal that 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3, calcitriol), the active metabolite of vitamin D (VD), promotes SIRT1 activation through auto-deacetylation in human colon carcinoma cells, and identify lysine 610 as an essential driver of SIRT1 activity. Remarkably, our data show that the post-translational control of SIRT1 activity mediates the antiproliferative action of 1,25(OH)2D3. This effect is reproduced by the SIRT1 activator SRT1720, suggesting that SIRT1 activators may offer new therapeutic possibilities for colon cancer patients who are VD deficient or unresponsive. Moreover, this might be extrapolated to inflammation and other VD deficiency-associated and highly prevalent diseases in which SIRT1 plays a prominent role.
Remapping in a recurrent neural network model of navigation and context inference
Authors: Low Isabel IC , Giocomo Lisa M , Williams Alex H
Published: May 2023

Neurons in navigational brain regions provide information about position, orientation, and speed relative to environmental landmarks. These cells also change their firing patterns (‘remap’) in response to changing contextual factors such as environmental cues, task conditions, and behavioral states, which influence neural activity throughout the brain. How can navigational circuits preserve their local computations while responding to global context changes? To investigate this question, we trained recurrent neural network models to track position in simple environments while at the same time reporting transiently-cued context changes. We show that these combined task constraints (navigation and context inference) produce activity patterns that are qualitatively similar to population-wide remapping in the entorhinal cortex, a navigational brain region. Furthermore, the models identify a solution that generalizes to more complex navigation and inference tasks. We thus provide a simple, general, and experimentally-grounded model of remapping as one neural circuit performing both navigation and context inference.
Different rules for binocular combination of luminance flicker in cortical and subcortical pathways
Authors: Segala Federico G. , Bruno Aurelio , Aung Myat T. , Wade Alex R. , Baker Daniel H.
Published: May 2023

How does the human brain combine information across the eyes? It has been known for many years that cortical normalisation mechanisms implement ‘ocularity invariance’: equalising neural responses to spatial patterns presented either monocularly or binocularly. Here we used a novel combination of electrophysiology, psychophysics, pupillometry and computational modelling to ask whether this invariance also holds for flickering luminance stimuli with no spatial contrast. We find dramatic violations of ocularity invariance for these stimuli, both in cortex and also in the subcortical pathways that govern pupil diameter. Specifically, we find substantial binocular facilitation in both pathways with the effect being strongest in cortex. Near-linear binocular additivity (instead of ocularity invariance) was also found using a perceptual luminance matching task. Ocularity invariance is therefore not a ubiquitous feature of visual processing, and the brain appears to repurpose a generic normalisation algorithm for different visual functions by adjusting the amount of interocular suppression.