bluuebunny/crossref_metadata_2025 huggingface dataset:
Carotid Ultrasound Screening Programs in Rural Communities: A Systematic Review
Authors: Petrova Marjana , Kiat Hosen , Gavino Alex , McLachlan Craig S.
Published: September 2021

Carotid atherosclerosis assessments inform about stroke and cardiovascular risk. It is known that stroke and cardiovascular disease (CVD) prevalence is higher in rural communities than in urban communities. We aimed to conduct a systematic review of rural carotid ultrasound screening programs to define carotid atherosclerosis using traditional and emerging imaging biomarkers, prevalence, and risk factors. We searched Ovid/MEDLINE, Ovid/EMBASE, SCOPUS and CINAHL from inception to 3 April 2020 for rural population studies that utilized carotid ultrasound screening for adults ≥40 years of age and free of known cerebrovascular disease. Studies were included if participants received a bilateral ultrasound scanning of the carotid arteries and reported at least one marker of carotid atherosclerosis pathology. A random effect meta-analyses calculated the estimated prevalence of carotid plaque. In total, 22/3461 articles that met all of the inclusion criteria were included. Studies reported increased intima media thickness (IMT), carotid plaque presence and carotid artery stenosis. There were no studies reporting on novel imaging markers, such as carotid stiffness, carotid plaque morphology or neovascularization. The overall random effect pooled prevalence of carotid plaque was 34.1% (95% CI, 33.6–35.0); the prevalence of increased IMT was 11.2–41.5%, and the prevalence of carotid artery stenosis was 0.4–16.0%. There is an absence of data necessary to understand the carotid atherosclerosis prevalence across global rural populations. Represented studies have focused on East Asian countries where a high burden of rural carotid artery disease has been reported. There is no rural evidence to guide the use of novel ultrasound carotid biomarkers such as stiffness or neovascularization.
Dynamic Impact of Unconventional Monetary Policy on International REITs
Authors: Marfatia Hardik A. , Gupta Rangan , Lesame Keagile
Published: September 2021

In this paper, we estimate the dynamic impact of unconventional monetary policy in the US on international REITs. Unlike existing studies which are limited to conventional policy tools and undertake a static approach, we use an event study approach and estimate a time-varying parameter model to investigate the dynamic impact of forward guidance (FG) and large-scale asset purchases (LSAP) shocks on the international REIT returns. We also compare the effects of these unconventional tools with the effects of conventional federal funds rate (FFR) shocks. The results show that the response of international REITs to unconventional policy shocks depends on the time under consideration. FG shocks have greater time-variation in the impact on REIT returns compared to LSAP shocks, particularly with Australia, Belgium, and the US REIT markets. Furthermore, FG shocks broadly have a negative impact on REITs while the results for LSAP effects are mixed. We also find that in most countries, REITs time-varying response of FG shocks is related to changes in gold prices and financial conditions.
Does an Animal–Visitor Interactive Experience Drive Conservation Action?
Authors: Collins Courtney Keane , McKeown Sean , O’Riordan Ruth
Published: September 2021

Inspiring visitors to engage in conservation-related behaviour following a zoo visit is a primary objective for most zoos. Animal–visitor interactive (AVI) experiences are often central to this goal. Yet, these interactive experiences are insufficiently evaluated from both the visitors’ and captive animals’ perspectives. The current study took place at Fota Wildlife Park and involved the construction of an environmental enrichment device during an interactive visitor experience with Sumatran tigers (Panthera tigris sumatrae). It aimed to simultaneously encourage pro-conservation behaviour in visitors and promote animal welfare. Visitors (n = 51) completed a survey, observed the tigers’ behaviour and made a pledge to help tigers in the wild after completion of the AVI. Tiger behaviour was simultaneously observed by a trained researcher using occurrence or non-occurrence sampling, which found no indication that tiger welfare was compromised during the activity and was likely enhanced by engaging with the enrichment. Additionally, visitors observed a range of tigers’ behaviours. The results indicated that some visitors (8%) had continued with their pledge six weeks after the experience, and most visitors exhibited a high level of knowledge and a positive attitude towards tigers. The use of enrichment during AVIs may be a positive link between the visitor experience and animal welfare. These results can be used to guide AVIs in zoos which aim to connect people with nature and drive pro-conservation behaviour in visitors.
Tourism Effect on the Spatiotemporal Pattern of Land Surface Temperature (LST): Babolsar and Fereydonkenar Cities (Cases Study in Iran)
Authors: Safarrad Taher , Ghadami Mostafa , Dittmann Andreas , Pazhuhan (Panahandeh Khah) Mousa
Published: September 2021

The purpose of this study is to investigate the effect of tourism on Land Surface Temperature (LST), an issue which has rarely been considered in the tourism development literature. In this research, remote sensing techniques have been used to analyze the changes in the LST and spectral indices including the Normalized Difference Vegetation Index (NDVI), Modified Normalized Difference Water Index (MNDWI) and Enhanced Built-Up and Bareness Index (EBBI). The data used were based on Landsat Collection 1 Surface Reflectance (SR) images taken in June and August. They were analyzed over 32 years in the years 1987, 1993, 1999, 2009, 2014 and 2019. The study area included the cities of Babolsar and Fereydonkenar and their suburbs in Mazandaran Province in the north of Iran and south of the Caspian Sea. First the tourism zones were separated from other land use zones and then the changes in land use and LST in each of the zones were studied for each year based on the trend of 32-year change. The results of Pearson correlation in the whole area for each main land use zone showed that there was a significant inverse relationship between the LST and the NDVI and MNDWI indices. This relationship was direct and significant for the EBBI index. Moreover, the results of one-way analysis of variance (ANOVA) and Tukey test showed that the LST changes in the tourism zones during the study period were significantly different from the other zones, so that the tourism zones always experienced lower LST. The findings also showed that, in the tourism zones, the values of the NDVI and MNDWI indices showed an increasing trend compared to the urban zone. Therefore, increasing the values of these indices due to the development of green space and its regular irrigation in tourism zones has led to a significant decrease in the LST. The applied results of this research in the urban planning and tourism literature indicate that any model of physical development such as urban development does not necessarily lead to an increase in the LST, and this is entirely dependent on the physical design strategies.
Towards the Use of Land Use Legacies in Landslide Modeling: Current Challenges and Future Perspectives in an Austrian Case Study
Authors: Knevels Raphael , Brenning Alexander , Gingrich Simone , Heiss Gerhard , Lechner Theresia , Leopold Philip , Plutzar Christoph , Proske Herwig , Petschko Helene
Published: September 2021

Land use/land cover (LULC) changes may alter the risk of landslide occurrence. While LULC has often been considered as a static factor representing present-day LULC, historical LULC dynamics have recently begun to attract more attention. The study objective was to assess the effect of LULC legacies of nearly 200 years on landslide susceptibility models in two Austrian municipalities (Waidhofen an der Ybbs and Paldau). We mapped three cuts of LULC patterns from historical cartographic documents in addition to remote-sensing products. Agricultural archival sources were explored to provide also a predictor on cumulative biomass extraction as an indicator of historical land use intensity. We use historical landslide inventories derived from high-resolution digital terrain models (HRDTM) generated using airborne light detection and ranging (LiDAR), which are reported to have a biased landslide distribution on present-day forested areas and agricultural land. We asked (i) if long-term LULC legacies are important and reliable predictors and (ii) if possible inventory biases may be mitigated by LULC legacies. For the assessment of the LULC legacy effect on landslide occurrences, we used generalized additive models (GAM) within a suitable modeling framework considering various settings of LULC as predictor, and evaluated the effect with well-established diagnostic tools. For both municipalities, we identified a high density of landslides on present-day forested areas, confirming the reported drawbacks. With the use of LULC legacy as an additional predictor, it was not only possible to account for this bias, but also to improve model performances.
The Endocannabinoid System: A Bridge between Alzheimer’s Disease and Gut Microbiota
Authors: Bisogno Tiziana , Lauritano Anna , Piscitelli Fabiana
Published: September 2021

Alzheimer’s disease (AD) is a neurodegenerative disease that progresses from mild cognitive impairment to severe dementia over time. The main clinical hallmarks of the disease (e.g., beta-amyloid plaques and neurofibrillary tangles) begin during preclinical AD when cognitive deficits are not yet apparent. Hence, a more profound understanding of AD pathogenesis is needed to develop new therapeutic strategies. In this context, the endocannabinoid (eCB) system and the gut microbiome are increasingly emerging as important players in maintaining the general homeostasis and the health status of the host. However, their interaction has come to light just recently with gut microbiota regulating the eCB tone at both receptor and enzyme levels in intestinal and adipose tissues. Importantly, eCB system and gut microbiome, have been suggested to play a role in AD in both animal and human studies. Therefore, the microbiome gut-brain axis and the eCB system are potential common denominators in the AD physiopathology. Hence, the aim of this review is to provide a general overview on the role of both the eCB system and the microbiome gut-brain axis in AD and to suggest possible mechanisms that underlie the potential interplay of these two systems.
A Short Review on Various Engineering Applications of Electrospun One-Dimensional Metal Oxides
Authors: Smok Weronika , Tański Tomasz
Published: September 2021

The growing scientific interest in one-dimensional (1D) nanostructures based on metal-oxide semiconductors (MOS) resulted in the analysis of their structure, properties and fabrication methods being the subject of many research projects and publications all over the world, including in Poland. The application of the method of electrospinning with subsequent calcination for the production of these materials is currently very popular, which results from its simplicity and the possibility to control the properties of the obtained materials. The growing trend of industrial application of electrospun 1D MOS and the progress in modern technologies of nanomaterials properties investigations indicate the necessity to maintain the high level of research and development activities related to the structure and properties analysis of low-dimensional nanomaterials. Therefore, this review perfectly fits both the global trends and is a summary of many years of research work in the field of electrospinning carried out in many research units, especially in the Department of Engineering Materials and Biomaterials of the Faculty of Mechanical Engineering and Technology of Silesian University of Technology, as well as an announcement of further activities in this field.
Bioactivity Evaluation of Biphasic Hydroxyapatite Bone Substitutes Immersed and Grown with Supersaturated Calcium Phosphate Solution
Authors: Yamaguchi Yusuke , Matsuno Tomonori , Miyazawa Atsuko , Hashimoto Yoshiya , Satomi Takafumi
Published: September 2021

Recently, the frequency of use of bone substitute materials for the purpose of bone augmentation has increased in implant treatment, but bone formation with bone substitute materials alone is limited. Calcification of bone in the body progresses as Ca2+, H2PO4-, and HPO42- in the body form hydroxyapatite (HA) crystals. In this study, therefore, we prepared a biphasic bone substitute with biological activity to promote bone formation by inducing precipitation and growth of HA crystals on the surface of a bone substitute and evaluated it. Biphasic bone substitute granules were prepared by immersing HA granules in a supersaturated calcium phosphate solution prepared by mixing five medical infusion solutions, the precipitate was analyzed, and the biological activities of biphasic HA granules were evaluated in vitro and in vivo. As a result, the precipitated calcium phosphate crystals were identified as low crystalline HA. On the surface of the HA granules, low-crystalline HA grew markedly as needle-shaped crystals and significantly promoted cell proliferation and bone differentiation. In animal experiments, biphasic HA granules had a significantly higher bone mineral density, new bone volume ratio, and new bone area ratio. Therefore, it suggests that biphasic hydroxyapatite is a useful bone substitute for bone augmentation in dental implant treatment.
Towards Analysis and Optimization for Contact Zone Temperature Changes and Specific Wear Rate of Metal Matrix Composite Materials Produced from Recycled Waste
Authors: Güneş Aydın , Salur Emin , Aslan Abdullah , Kuntoğlu Mustafa , Giasin Khaled , Pimenov Danil Yurievich , Düzcükoğlu Hayrettin , Şahin Ömer Sinan
Published: September 2021

Tribological properties are important to evaluate the in-service conditions of machine elements, especially those which work as tandem parts. Considering their wide range of application areas, metal matrix composites (MMCs) serve as one of the most significant materials equipped with desired mechanical properties such as strength, density, and lightness according to the place of use. Therefore, it is crucial to determine the wear performance of these materials to obtain a longer life and to overcome the possible structural problems which emerge during the production process. In this paper, extensive discussion and evaluation of the tribological performance of newly produced spheroidal graphite cast iron-reinforced (GGG-40) tin bronze (CuSn10) MMCs, including optimization, statistical, graphical, and microstructural analysis for contact zone temperature and specific wear rate, are presented. For this purpose, two levels of production temperature (400 and 450 °C), three levels of pressure (480, 640, and 820 MPa), and seven different samples reinforced by several ingredients (from 0 to 40 wt% GGG-40, pure CuSn10, and GGG-40) were investigated. According to the obtained statistical results, the reinforcement ratio is remarkably more effective on contact zone temperature and specific wear rate than temperature and pressure. A pure CuSn10 sample is the most suitable option for contact zone temperature, while pure GGG-40 seems the most suitable material for specific wear rates according to the optimization results. These results reveal the importance of reinforcement for better mechanical properties and tribological performance in measuring the capability of MMCs.
Performance of an Indirect Packed Bed Reactor for Chemical Energy Storage
Authors: Delise Tiziano , Sau Salvatore , Tizzoni Anna Chiara , Spadoni Annarita , Corsaro Natale , Liberatore Raffaele , Morabito Tania , Mansi Emiliana
Published: September 2021

Chemical systems for thermal energy storage are promising routes to overcome the issue of solar irradiation discontinuity, helping to improve the cost-effectiveness and dispatchability of this technology. The present work is concerned with the simulation of a configuration based on an indirect-packed bed heat exchanger, for which few experimental and modelling data are available about practical applications. Since air shows advantages both as a reactant and heat transfer fluid, the modelling was performed considering a redox oxide based system, and, for this purpose, it was considered a pelletized aluminum/manganese spinel. A symmetrical configuration was selected and the calculation was carried out considering a heat duty of 125 MWth and a storage period of 8 h. Firstly, the heat exchanger was sized considering the mass and energy balances for the discharging step, and, subsequently, air inlet temperature and mass flow were determined for the charging step. The system performances were then modelled as a function of the heat exchanger length and the charging and discharging time, by solving the relative 1D Navier-Stokes equations. Despite limitations in the global heat exchange efficiency, resulting in an oversize of the storage system, the results showed a good storage efficiency of about 0.7.
Performance of a Piezoelectric Energy Harvesting System for an Energy-Autonomous Instrumented Total Hip Replacement: Experimental and Numerical Evaluation
Authors: Lange Hans-E. , Arbeiter Nils , Bader Rainer , Kluess Daniel
Published: September 2021

Instrumented implants can improve the clinical outcome of total hip replacements (THRs). To overcome the drawbacks of external energy supply and batteries, energy harvesting is a promising approach to power energy-autonomous implants. Therefore, we recently presented a new piezoelectric-based energy harvesting concept for THRs. In this study, the performance of the proposed energy harvesting system was numerically and experimentally investigated. First, we numerically reproduced our previous results for the physiologically based loading situation in a simplified setup. Thereafter, this configuration was experimentally realised by the implantation of a functional model of the energy harvesting concept into an artificial bone segment. Additionally, the piezoelectric element alone was investigated to analyse the predictive power of the numerical model. We measured the generated voltage for a load profile for walking and calculated the power output. The maximum power for the directly loaded piezoelectric element and the functional model were 28.6 and 10.2 µW, respectively. Numerically, 72.7 µW was calculated. The curve progressions were qualitatively in good accordance with the numerical data. The deviations were explained by sensitivity analysis and model simplifications, e.g., material data or lower acting force levels by malalignment and differences between virtual and experimental implantation. The findings verify the feasibility of the proposed energy harvesting concept and form the basis for design optimisations with increased power output.
Effect of Heat Treatments under High Isostatic Pressure on the Transport Critical Current Density at 4.2 K and 20 K in Doped and Undoped MgB2 Wires
Authors: Gajda Daniel , Zaleski Andrzej J. , Morawski Andrzej J. , Małecka Malgorzata , Nenkov Konstantin , Rindfleisch Matt , Hossain Md Shahriar A. , Czujko Tomasz
Published: September 2021

Annealing undoped MgB2 wires under high isostatic pressure (HIP) increases transport critical current density (Jtc) by 10% at 4.2 K in range magnetic fields from 4 T to 12 T and significantly increases Jtc by 25% in range magnetic fields from 2 T to 4 T and does not increase Jtc above 4 T at 20 K. Further research shows that a large amount of 10% SiC admixture and thermal treatment under a high isostatic pressure of 1 GPa significantly increases the Jtc by 40% at 4.2 K in magnetic fields above 6 T and reduces Jtc by one order at 20 K in MgB2 wires. Additionally, our research showed that heat treatment under high isostatic pressure is more evident in wires with smaller diameters, as it greatly increases the density of MgB2 material and the number of connections between grains compared to MgB2 wires with larger diameters, but only during the Mg solid-state reaction. In addition, our study indicates that smaller wire diameters and high isostatic pressure do not lead to a higher density of MgB2 material and more connections between grains during the liquid-state Mg reaction.
The Effect of Rare Earth Metals Alloying on the Internal Quality of Industrially Produced Heavy Steel Forgings
Authors: Jonšta Petr , Jonšta Zdeněk , Brožová Silvie , Ingaldi Manuela , Pietraszek Jacek , Klimecka-Tatar Dorota
Published: September 2021

The paper presented the findings obtained by industrial research and experimental development on the use of rare earth metals (REMs) in the production of heavy steel ingots and their impact on the internal quality of the 42CrMo4 grade steel forging. REMs alloying was carried out after vacuuming the steel. A relatively large melting loss of cerium (about 50%) and its further decrease in casting due to reoxidation were observed. Refinement of structure and better mechanical properties of forged bar containing about 0.02 wt.% of Ce compared to that of the standard production were not achieved. The wind power shaft with content of about 0.06 wt.% of Ce showed high amount of REM inclusions, which were locally chained, and in some cases, initiated cracks. Four stoichiometrically different types of REM inclusions were detected in forgings, namely (La-Ce)2O2S + (La-Ce)O2 + SiO2 (minority); oxygen, phosphorus, arsenic, and antimony bound to lanthanum and cerium probably bonded with iron oxides La + Ce, MgO, Al2O3 a SiO2; (La-Ce)2O2S, FeO, SiO2, and CaO or CaS.
Adaptive Secure Control for Leader-Follower Formation of Nonholonomic Mobile Robots in the Presence of Uncertainty and Deception Attacks
Authors: Park Bong-Seok , Yoo Sung-Jin
Published: September 2021

This paper addresses an adaptive secure control problem for the leader-follower formation of nonholonomic mobile robots in the presence of uncertainty and deception attacks. It is assumed that the false data of the leader robot’s information attacked by the adversary is transmitted to the follower robot through the network, and the dynamic model of each robot has uncertainty, such as unknown nonlinearity and external disturbances. A robust, adaptive secure control strategy compensating for false data and uncertainty is developed to accomplish the desired formation of nonholonomic mobile robots. An adaptive compensation mechanism is derived to remove the effects of time-varying attack signals and system uncertainties in the proposed control scheme. Although unknown deception attacks are injected to the leader’s velocities and the model nonlinearities of robots are unknown, the boundedness and convergence of formation tracking errors of the proposed adaptive control system are analyzed in the Lyapunov sense. The validity of the proposed scheme is verified via simulation results.
Sensitivity, Equilibria, and Lyapunov Stability Analysis in Droop’s Nonlinear Differential Equation System for Batch Operation Mode of Microalgae Culture Systems
Authors: Guzmán-Palomino Abraham , Aguilera-Vázquez Luciano , Hernández-Escoto Héctor , García-Vite Pedro Martin
Published: September 2021

Microalgae-based biomass has been extensively studied because of its potential to produce several important biochemicals, such as lipids, proteins, carbohydrates, and pigments, for the manufacturing of value-added products, such as vitamins, bioactive compounds, and antioxidants, as well as for its applications in carbon dioxide sequestration, amongst others. There is also increasing interest in microalgae as renewable feedstock for biofuel production, inspiring a new focus on future biorefineries. This paper is dedicated to an in-depth analysis of the equilibria, stability, and sensitivity of a microalgal growth model developed by Droop (1974) for nutrient-limited batch cultivation. Two equilibrium points were found: the long-term biomass production equilibrium was found to be stable, whereas the equilibrium in the absence of biomass was found to be unstable. Simulations of estimated parameters and initial conditions using literature data were performed to relate the found results to a physical context. In conclusion, an examination of the found equilibria showed that the system does not have isolated fixed points but rather has an infinite number of equilibria, depending on the values of the minimal cell quota and initial conditions of the state variables of the model. The numerical solutions of the sensitivity functions indicate that the model outputs were more sensitive, in particular, to variations in the parameters of the half saturation constant and minimal cell quota than to variations in the maximum inorganic nutrient absorption rate and maximum growth rate.
Incorporating Fuzzy Logic in Harrod’s Economic Growth Model
Authors: Ferrer-Comalat Joan Carles , Linares-Mustarós Salvador , Rigall-Torrent Ricard
Published: September 2021

This paper suggests the possibility of incorporating the methodology of fuzzy logic theory into Harrod’s economic growth model, a classic model of economic dynamics for studying the growth of a developing economy based on the assumption that an economy with only savings and investment income is in equilibrium when savings are equal to investment. This model was the first precursor to exogenous growth models, which in turn gave rise to endogenous growth models. This article therefore represents a first step towards introducing fuzzy logic into economic growth models. The study concerned considers consumption and savings to depend on income by means of uncertain factors, and investment to depend on the variation of income through the accelerator factor, which we consider uncertain. These conditions are used to determine the equilibrium growth rate of income and investment, as well as the uncertain values for these variables in terms of fuzzy numbers. As a result, the new model is shown to expand the classical model by incorporating uncertainty into its variables.
Analysis of the Impact of Comorbidities on Endometrial Lesions Using the Charlson Comorbidity Index in Western Romania
Authors: Furau Alexandru , Tit Delia Mirela , Furau Cristian , Bungau Simona , Furau Gheorghe , Toma Mirela Marioara , Cirstoveanu Catalin Gabriel , Petre Izabella , Todor Denisia-Suzana , Romosan Radu Stefan , Craina Marius
Published: September 2021

Background and Objectives: This retrospective study aimed to identify the main comorbidities found in gynecological patients hospitalized for endometrial lesions and to analyze the relationships between these comorbidities and each type of endometrial lesion. The Charlson comorbidity index (CCI) was calculated, thus assessing the patient’s probability of survival in relation to the underlying disease and the existing comorbidities. Materials and Methods: During 2015–2019, 594 cases hospitalized for vaginal bleeding outside of pregnancy were included in the research. For all cases, the frequency of comorbidities was calculated, applying the Cox proportional hazard model, considering the hospitalizations (from the following year after the first outpatient or hospital assessment) as a dependent variable; age and comorbidities were considered as independent variables. Results: Analysis of variance (ANOVA) for mean age of patients enrolled after diagnosis and multiple comparisons (via the Tukey post-hoc test) indicate significant differences (p < 0.05) between the average age for endometrial cancer (EC) and that for the typical endometrial hyperplasia or other diagnoses. The most common comorbidities were hypertension (62.28%), obesity (35.01%), and diabetes (22.89%), followed by cardiovascular disease. An intensely negative correlation (r = −0.715281634) was obtained between the percentage values of comorbidities present in EC and other endometrial lesions. The lowest chances of survival were calculated for 88 (14.81% of the total) patients over 50 years (the probability of survival in the next 10 years being between 0 and 21%). The chances of survival at 10 years are moderately negatively correlated with age (sample size = 594, r = −0.6706, p < 0.0001, 95% confidence interval (CI) for r having values from −0.7126 to −0.6238) and strongly negatively correlated with the CCI (r = −0.9359, p < 0.0001, 95% CI for r being in the range −0.9452 to −0.9251). Conclusions: Using CCI in endometrial lesions is necessary to compare the estimated risk of EC mortality with other medical conditions.
Using an Electromyography Method While Measuring Oxygen Uptake to Appreciate Physical Exercise Intensity in Adolescent Cyclists: An Analytical Study
Authors: Martin Ștefan Adrian , Martin-Hadmaș Roxana Maria
Published: September 2021

Background and Objectives: During physical exercise, the electrical signal of the muscle fibers decreases due to repeated muscle contractions held at different intensities. The measured signal is strongly related to the motor unit activation rate, which is dependent on the chemical mediators and the available energy. By reducing the energy availability, adenosine triphosphate (ATP) production will decrease and therefore the muscle fibers activation rate will be negatively affected. Such aspects become important when taking into account that the training intensity for many young athletes is rather controlled by using the heart rate values. Yet, on many occasions, we have seen differences and lack of relationship between the muscle activation rate, the heart rate values and the lactate accumulation. Materials and Methods: We conducted a prospective analytical study conducted during a 4-month period, on a sample of 30 participants. All study participants underwent an incremental exercise bike test to measure maximum aerobic capacity as well as the muscle activation rate in the vastus lateralis by using an electromyography method (EMG). Results: With age, the EMG signal dropped, as did the electromyography fatigue threshold (EMGFT) point, as seen through p = 0.0057, r = −0.49, CI95% = −0.73 to −0.16, and electromyography maximum reached point (EMGMRP) (p = 0.0001, r = −0.64, CI95% = −0.82 to −0.36), whereas power output increased (p = 0.0186, r = 0.427). The higher the power output, the lower the signal seen by measuring active tissue EMGFT (p = 0.0324, r = −0.39) and EMGMRP (p = 0.0272, r = −0.40). Yet, with changes in median power output, the power developed in aerobic (p = 0.0087, r = 0.47), mixed (p = 0.0288, r = 0.39), anaerobic (p = 0.0052, r = 0.49) and anaerobic power (p = 0.004, r = 0.50) exercise zones increased. Conclusions: There has been reported a relationship between aerobic/anaerobic ventilatory thresholds (VT1 and VT2) and EMGFT, EMGMRP, respectively. Each change in oxygen uptake increased the power output in EMGFT and EMGMRP, improving performances and therefore overlapping with both ventilatory thresholds.
Brazing Tungsten/Tantalum/RAFM Steel Joint for DEMO by Fully Reduced Activation Brazing Alloy 48Ti-48Zr-4Be
Authors: Bachurina Diana , Suchkov Alexey , Gurova Julia , Kliucharev Vladislav , Vorkel Vladimir , Savelyev Maxim , Somov Pavel , Sevryukov Oleg
Published: September 2021

To create a DEMO reactor, it is necessary to develop high-quality technology to join tungsten with reduced-activation ferritic-martensitic (RAFM) steel (Rusfer, Eurofer, CLF-1, etc.). Difficulties arise in their direct connection due to the large difference in the coefficient of thermal expansion (CTE). To suppress the difference of CTE, intermediate interlayers are usually used, such as vanadium or tantalum, and brazing is a prospective technology to conduct the joining. The vast majority of works represent copper- or nickel-based brazing alloys, but their applicability is under significant discussion due to their activation properties. That is why, in this work, fully reduced activation 48Ti-48Zr-4Be wt.% brazing alloy was used. The following joint was made: Rusfer steel/48Ti-48Zr-4Be/Ta/48Ti-48Zr-4Be/W. The brazing was successfully carried out under a mode providing thermal heat treatment of Rusfer. Through EDS and EBSD analysis, the microstructure of the joint was determined. Shear strength of the as-joined composition was measured as 127 ± 20 MPa. The joint endured 200 thermocycles in the temperature range between 300–600 °C, but the fillet regions degraded.
The Thermal Properties of L12 Phases in Aluminum Enhanced by Alloying Elements
Authors: Lan Jihang , Chen Zhaoqun , Liu Linghong , Zhang Qingzhou , He Mengdong , Li Jianbo , Peng Xiaofang , Fan Touwen
Published: September 2021

The L12 type trialuminide compounds Al3M possess outstanding mechanical properties, which enable them to be ideal for dispersed strengthening phases for the high-strength thermally stable Al based alloys. Ab-initio calculations based on the density functional theory (DFT) were performed to study the structural, electronic, thermal, and thermodynamic properties of L12-Al3M (M = Er, Hf, Lu, Sc, Ti, Tm, Yb, Li, Mg, Zr) structures in Al alloys. The total energy calculations showed that the L12 structures are quite stable. On the basis of the thermodynamic calculation, we found that the Yb, Lu, Er, and Tm atoms with a larger atomic radii than Al promoted the thermal stability of the Al alloys, and the thermal stability rank has been constructed as: Al3Yb > Al3Lu > Al3Er > Al3Tm > Al, which shows an apparent positive correlation between the atomic size and thermal stability. The chemical bond offers a firm basis upon which to forge links not only within chemistry but also with the macroscopic properties of materials. A careful analysis of the charge density indicated that Yb, Lu, Er, and Tm atoms covalently bonded to Al, providing a strong intrinsic basis for the thermal stability of the respective structures, suggesting that the addition of big atoms (Yb, Lu, Er, and Tm) are beneficial for the thermal stability of Al alloys.
Rubber Seed Oil-Based UV-Curable Polyurethane Acrylate Resins for Digital Light Processing (DLP) 3D Printing
Authors: Hu Yun , Zhu Guoqiang , Zhang Jinshuai , Huang Jia , Yu Xixi , Shang Qianqian , An Rongrong , Liu Chengguo , Hu Lihong , Zhou Yonghong
Published: September 2021

Novel UV-curable polyurethane acrylate (PUA) resins were developed from rubber seed oil (RSO). Firstly, hydroxylated rubber seed oil (HRSO) was prepared via an alcoholysis reaction of RSO with glycerol, and then HRSO was reacted with isophorone diisocyanate (IPDI) and hydroxyethyl acrylate (HEA) to produce the RSO-based PUA (RSO-PUA) oligomer. FT-IR and 1H NMR spectra collectively revealed that the obtained RSO-PUA was successfully synthesized, and the calculated C=C functionality of oligomer was 2.27 per fatty acid. Subsequently, a series of UV-curable resins were prepared and their ultimate properties, as well as UV-curing kinetics, were investigated. Notably, the UV-cured materials with 40% trimethylolpropane triacrylate (TMPTA) displayed a tensile strength of 11.7 MPa, an adhesion of 2 grade, a pencil hardness of 3H, a flexibility of 2 mm, and a glass transition temperature up to 109.4 °C. Finally, the optimal resin was used for digital light processing (DLP) 3D printing. The critical exposure energy of RSO-PUA (15.20 mJ/cm2) was lower than a commercial resin. In general, this work offered a simple method to prepare woody plant oil-based high-performance PUA resins that could be applied in the 3D printing industry.
Halomethyl-Triazoles for Rapid, Site-Selective Protein Modification
Authors: Brewster Richard C. , Hulme Alison N.
Published: September 2021

Post-translational modifications (PTMs) are used by organisms to control protein structure and function after protein translation, but their study is complicated and their roles are not often well understood as PTMs are difficult to introduce onto proteins selectively. Designing reagents that are both good mimics of PTMs, but also only modify select amino acid residues in proteins is challenging. Frequently, both a chemical warhead and linker are used, creating a product that is a misrepresentation of the natural modification. We have previously shown that biotin-chloromethyl-triazole is an effective reagent for cysteine modification to give S-Lys derivatives where the triazole is a good mimic of natural lysine acylation. Here, we demonstrate both how the reactivity of the alkylating reagents can be increased and how the range of triazole PTM mimics can be expanded. These new iodomethyl-triazole reagents are able to modify a cysteine residue on a histone protein with excellent selectivity in 30 min to give PTM mimics of acylated lysine side-chains. Studies on the more complicated, folded protein SCP-2L showed promising reactivity, but also suggested the halomethyl-triazoles are potent alkylators of methionine residues.
Strawberry Juice Powders: Effect of Spray-Drying Conditions on the Microencapsulation of Bioactive Components and Physicochemical Properties
Authors: Leyva-Porras César , Saavedra-Leos María Zenaida , López-Martinez Laura Araceli , Espinosa-Solis Vicente , Terán-Figueroa Yolanda , Toxqui-Terán Alberto , Compeán-Martínez Isaac
Published: September 2021

The drying of fruit juices has advantages such as easy handling of powders, reduction in volume, and preservation of the characteristics of the fruit. Thus, in this work, the effect of the spray drying conditions of strawberry juice (SJ) with maltodextrin (MX) as a carrying agent on the microencapsulation of bioactive compounds and physicochemical properties was studied. The content of phenolic compounds and antioxidant activity showed higher values at low concentrations of MX, while the effect of drying temperature was negligible. The thermal characterization showed that the low molecular weight sugars in the juice decreased the glass transition temperature (Tg). The morphological analysis by scanning electron microscopy (SEM) indicated that at low concentrations of MX, the particles agglomerated, while at intermediate and high concentrations, the particles were observed as well separated. Through microstructural analysis by X-ray diffraction (XRD), the presence of amorphous state was confirmed in all the samples, which is beneficial for preventing chemical and biochemical reactions, and promoting the conservation of the microencapsulated bioactive compounds.
Risk-Benefit Assessment of Cereal-Based Foods Consumed by Portuguese Children Aged 6 to 36 Months—A Case Study under the RiskBenefit4EU Project
Authors: Assunção Ricardo , Boué Géraldine , Alvito Paula , Brazão Roberto , Carmona Paulo , Carvalho Catarina , Correia Daniela , Fernandes Paulo , Lopes Carla , Martins Carla , Membré Jeanne-Marie , Monteiro Sarogini , Nabais Pedro , Thomsen Sofie T. , Torres Duarte , Pires Sara M. , Jakobsen Lea S.
Published: September 2021

Cereal-based foods, including breakfast (BC) and infant cereals (IC), are among the first solid foods introduced to infants. BC and IC are sources of macro and micronutrients that have beneficial effects on health, but can also be sources of harmful chemical and microbiological contaminants and nutrients that may lead to adverse health effects at high consumption levels. This study was performed under the RiskBenefit4EU project with the aim of assessing the health impact associated with consumption of BC and IC by Portuguese children under 35 months. Adverse effects associated with the presence of aflatoxins, Bacillus cereus, sodium and free sugars were assessed against the benefits of fiber intake. We applied a risk–benefit assessment approach, and quantified the health impact of changes in consumption of BC and IC from current to various alternative consumption scenarios. Health impact was assessed in terms of disability-adjusted life years. Results showed that moving from the current consumption scenario to considered alternative scenarios results in a gain of healthy life years. Portuguese children can benefit from exchanging intake of IC to BC, if the BC consumed has an adequate nutritional profile in terms of fiber, sodium and free sugars, with levels of aflatoxins reduced as much as possible.
Maternal Dietary Quality and Dietary Inflammation Associations with Offspring Growth, Placental Development, and DNA Methylation
Authors: Lecorguillé Marion , Teo Shevaun , Phillips Catherine M.
Published: September 2021

The ‘Developmental Origins of Health and Diseases’ hypothesis posits that prenatal maternal diet influences offspring growth and later life health outcomes. Dietary assessment has focused on selected nutrients. However, this approach does not consider the complex interactions between foods and nutrients. To provide a more comprehensive approach to public health, dietary indices have been developed to assess dietary quality, dietary inflammation and risk factors for non-communicable diseases. Thus far, their use in the context of placental development is limited and associations with offspring outcomes have been inconsistent. Although epidemiological studies have focused on the role of maternal diet on foetal programming, the underlying mechanisms are still poorly understood. Some evidence suggests these associations may be driven by placental and epigenetic changes. In this narrative review, we examine the current literature regarding relationships between key validated diet quality scores (Dietary Inflammatory Index [DII], Mediterranean diet [MD], Healthy Eating Index [HEI], Alternative Healthy Eating Index [AHEI], Dietary Approaches to Stop Hypertension [DASH], Glycaemic Index [GI] and Glycaemic Load [GL]) in pregnancy and birth and long-term offspring outcomes. We summarise findings, discuss potential underlying placental and epigenetic mechanisms, in particular DNA methylation, and highlight the need for further research and public health strategies that incorporate diet quality and epigenetics.
L-Citrulline Supplementation and Exercise in the Management of Sarcopenia
Authors: Caballero-García Alberto , Pascual-Fernández Jorge , Noriega-González David César , Bello Hugo J. , Pons-Biescas Antoni , Roche Enrique , Córdova-Martínez Alfredo
Published: September 2021

Sarcopenia is a process associated to aging. Persistent inflammation and oxidative stress in muscle favour muscle wasting and decreased ability to perform physical activity. Controlled exercise can optimize blood flux and moderate the production of reactive oxygen species. Therefore, supplements that can work as a vasodilators and control oxidative stress, might be beneficial for active elders. In this context, we have tested citrulline supplementation in a group of 44 participants aged from 60–73 years that followed a physical activity program adapted to their age and capacities. Volunteers were divided in two groups: placebo (n = 22) and citrullline supplemented (n = 22). Different physical tests and blood extractions were performed at the beginning and at the end of intervention (six weeks). Strength and endurance showed a tendency to increase in the citrulline supplemented group, with no significant differences respect to placebo. However, walking speed in the citrulline supplemented group improved significantly compared to placebo. Markers of muscle damage as well as circulating levels of testosterone, cortisol and vitamin D showed no significant changes, but a tendency to improve at the end of intervention in the supplemented group compared to placebo. Additional studies are necessary to confirm the effect of citrulline supplementation in sarcopenia delay.
The Perception of Vitamins and Their Prevalence in Fortified Food and Supplements in Japan
Authors: Chiba Tsuyoshi , Tanemura Nanae , Nishijima Chiharu
Published: September 2021

Most vitamins are primarily ingested from foods. However, it has been reported that intakes of some vitamins do not meet the nutrition reference values even in high-income countries. In this case, vitamin-fortified foods and/or vitamin supplements are helpful to fix insufficient/deficient status. However, it is not clear whether consumers are aware of their nutritional status or whether they use these products efficiently. To address this issue, we conducted an online cross-sectional questionnaire survey among 14,741 Japanese adults (over 20 years old, 7489 males and 7252 females) concerning the perceptions and prevalence of vitamin-fortified food and/or vitamin supplements. Differences in distribution among groups were compared using the chi-squared test. According to dietary habits, 33.2% of the participants consumed a well-balanced diet every day, but 25.5% could not because of time (41.6%) or money (36.9%) constraints. The perception of each vitamin varied: the highest was for vitamin C (93.2%) and the lowest was for biotin (41.9%). In addition, only a portion of the participants believed that they took sufficient amounts of each vitamin; the highest was vitamin C (22.3%) and the lowest was biotin (5.2%). Despite this situation, most did not use vitamin-fortified food and/or vitamin supplements due to economic reasons. Among vitamin-fortified food and/or vitamin supplement users, the purposes for the usage of these products were varied, such as maintaining health (80.5%), supplementation of nutrients (47.8%), beauty-related purposes (27.5%), and to prevent infectious disease (23.2%). To remedy nutritional status in individuals, it is important to improve not only consumer awareness but also the environment, which can lead consumers to use acceptable vitamin products without any burden.
3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
Authors: Xu Xiaoyan , Awwad Sahar , Diaz-Gomez Luis , Alvarez-Lorenzo Carmen , Brocchini Steve , Gaisford Simon , Goyanes Alvaro , Basit Abdul W.
Published: September 2021

Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and polyethylene glycol 400 (PEG 400) to create a semi-interpenetrating network (semi-IPN). Drug-loaded punctal plugs were characterised in terms of physical characteristics (XRD and DSC), potential drug-photopolymer interactions (FTIR), drug release profile, and cytocompatibility. In vitro release kinetics of the punctal plugs were evaluated using an in-house flow rig model that mimics the subconjunctival space. The results showed sustained release of dexamethasone for up to 7 days from punctal plugs made with 20% w/w PEG 400 and 80% w/w PEGDA, while punctal plugs made with 100% PEGDA exhibited prolonged releases for more than 21 days. Herein, our study demonstrates that DLP 3D printing represents a potential manufacturing platform for fabricating personalised drug-loaded punctal plugs with extended release characteristics for ocular administration.