bluuebunny/crossref_metadata_2025 huggingface dataset:
PROFAST: A Randomized Trial Assessing the Effects of Intermittent Fasting and Lacticaseibacillus rhamnosus Probiotic among People with Prediabetes
Authors: Tay Audrey , Pringle Hannah , Penning Elise , Plank Lindsay D. , Murphy Rinki
Published: November 2020

Both intermittent fasting and specific probiotics have shown promise in improving glucose tolerance with a potential for synergistic effects through alterations to gut microbiota. In this randomized, double-blinded, two-arm feasibility study, we investigated whether intermittent fasting, supplemented with Lacticaseibacillus rhamnosus HN001 probiotic, reduces HbA1c in individuals with prediabetes. All participants with HbA1c 40–50 mmol/mol commenced intermittent fasting (2 days per week of calorie restriction to 600–650 kcal/day) and were randomized 1:1 to either daily probiotic (Lacticaseibacillus rhamnosus HN001) or placebo for 12 weeks. The primary outcome was a change in HbA1c. Secondary outcomes included changes in anthropometry, body composition, glucoregulatory markers, lipids, hunger hormones, liver enzymes, inflammatory markers, gut hormones, calorie and macronutrient intake, quality of life, hunger, mood and eating behavior. Of 33 participants who commenced the trial, 26 participants (mean age 52 years, body mass index (BMI) 34.7 kg/m2) completed the intervention (n = 11 placebo, n = 15 probiotic). HbA1c decreased from 43 ± 2.7 mmol/mol to 41 ± 2.3 mmol/mol, p < 0.001, with average of 5% weight loss. No significant between-group differences were seen in primary or secondary outcomes except for social functioning (p = 0.050) and mental health (p = 0.007) scores as improvements were seen in the probiotic group, but not in the placebo group. This study shows additional psychological benefits of probiotic supplementation during intermittent fasting to achieve weight loss and glycemic improvement in prediabetes.
Introduction to “Immunotherapies for Multiple Myeloma”
Authors: Offidani Massimo , Petrucci Maria Teresa
Published: November 2020

Multiple myeloma (MM) is the second most common hematological cancer after diffuse large B-cell lymphoma, accounting for about 10% of all blood cancers [...]
Fungal Enzyme l-Lysine α-Oxidase Affects the Amino Acid Metabolism in the Brain and Decreases the Polyamine Level
Authors: Lukasheva Elena , Makletsova Marina , Lukashev Alexander , Babayeva Gulalek , Arinbasarova Anna , Medentsev Alexander
Published: November 2020

The fungal glycoprotein l-lysine α-oxidase (LO) catalyzes the oxidative deamination of l-lysine (l-lys). LO may be internalized in the intestine and shows antitumor, antibacterial, and antiviral effects in vivo. The main mechanisms of its effects have been shown to be depletion of the essential amino acid l-lys and action of reactive oxidative species produced by the reaction. Here, we report that LO penetrates into the brain and is retained there for up to 48 h after intravenous injection, which might be explained by specific pharmacokinetics. LO actively intervenes in amino acid metabolism in the brain. The most significant impact of LO was towards amino acids, which are directly exposed to its action (l-lys, l-orn, l-arg). In addition, the enzyme significantly affected the redistribution of amino acids directly associated with the tricarboxylic acid (TCA) cycle (l-asp and l-glu). We discovered that the depletion of l-orn, the precursor of polyamines (PA), led to a significant and long-term decrease in the concentration of polyamines, which are responsible for regulation of many processes including cell proliferation. Thus, LO may be used to reduce levels of l-lys and PA in the brain.
Formulation of pH-Responsive Quatsomes from Quaternary Bicephalic Surfactants and Cholesterol for Enhanced Delivery of Vancomycin against Methicillin Resistant Staphylococcus aureus
Authors: Hassan Daniel , Omolo Calvin A. , Fasiku Victoria Oluwaseun , Elrashedy Ahmed A , Mocktar Chunderika , Nkambule Bongani , Soliman Mahmoud E. S. , Govender Thirumala
Published: November 2020

Globally, human beings continue to be at high risk of infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA); and current treatments are being depleted due to antimicrobial resistance. Therefore, the synthesis and formulation of novel materials is essential for combating antimicrobial resistance. The study aimed to synthesize a quaternary bicephalic surfactant (StBAclm) and thereof to formulate pH-responsive vancomycin (VCM)-loaded quatsomes to enhance the activity of the antibiotic against MRSA. The surfactant structure was confirmed using 1H, 13C nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FT-IR), and high-resolution mass spectrometry (HRMS). The quatsomes were prepared using a sonication/dispersion method and were characterized using various in vitro, in vivo, and in silico techniques. The in vitro cell biocompatibility studies of the surfactant and pH-responsive vancomycin-loaded quatsomes (VCM-StBAclm-Qt1) revealed that they are biosafe. The prepared quatsomes had a mean hydrodynamic diameter (MHD), polydispersity index (PDI), and drug encapsulation efficiency (DEE) of 122.9 ± 3.78 nm, 0.169 ± 0.02 mV, and 52.22 ± 8.4%, respectively, with surface charge switching from negative to positive at pH 7.4 and pH 6.0, respectively. High-resolution transmission electron microscopy (HR-TEM) characterization of the quatsomes showed spherical vesicles with MHD similar to the one obtained from the zeta-sizer. The in vitro drug release of VCM from the quatsomes was faster at pH 6.0 compared to pH 7.4. The minimum inhibitory concentration (MIC) of the drug loaded quatsomes against MRSA was 32-fold and 8-fold lower at pH 6.0 and pH 7.4, respectively, compared to bare VCM, demonstrating the pH-responsiveness of the quatsomes and the enhanced activity of VCM at acidic pH. The drug-loaded quatsomes demonstrated higher electrical conductivity and a decrease in protein and deoxyribonucleic acid (DNA) concentrations as compared to the bare drug. This confirmed greater MRSA membrane damage, compared to treatment with bare VCM. The flow cytometry study showed that the drug-loaded quatsomes had a similar bactericidal killing effect on MRSA despite a lower (8-fold) VCM concentration when compared to the bare VCM. Fluorescence microscopy revealed the ability of the drug-loaded quatsomes to eradicate MRSA biofilms. The in vivo studies in a skin infection mice model showed that groups treated with VCM-loaded quatsomes had a 13-fold decrease in MRSA CFUs when compared to the bare VCM treated groups. This study confirmed the potential of pH-responsive VCM-StBAclm quatsomes as an effective delivery system for targeted delivery and for enhancing the activity of antibiotics.
Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations
Authors: Adu Simms A. , Naughton Patrick J. , Marchant Roger , Banat Ibrahim M.
Published: November 2020

Cosmetic and personal care products are globally used and often applied directly on the human skin. According to a recent survey in Europe, the market value of cosmetic and personal care products in Western Europe reached about 84 billion euros in 2018 and are predicted to increase by approximately 6% by the end of 2020. With these significant sums of money spent annually on cosmetic and personal care products, along with chemical surfactants being the main ingredient in a number of their formulations, of which many have been reported to have the potential to cause detrimental effects such as allergic reactions and skin irritations to the human skin; hence, the need for the replacement of chemical surfactants with other compounds that would have less or no negative effects on skin health. Biosurfactants (surfactants of biological origin) have exhibited great potential such as lower toxicity, skin compatibility, protection and surface moisturizing effects which are key components for an effective skincare routine. This review discusses the antimicrobial, skin surface moisturizing and low toxicity properties of glycolipid and lipopeptide biosurfactants which could make them suitable substitutes for chemical surfactants in current cosmetic and personal skincare pharmaceutical formulations. Finally, we discuss some challenges and possible solutions for biosurfactant applications.
I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets
Authors: Januskaite Patricija , Xu Xiaoyan , Ranmal Sejal R. , Gaisford Simon , Basit Abdul W. , Tuleu Catherine , Goyanes Alvaro
Published: November 2020

3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges such as dose flexibility, patient compliance, taste masking and the fear or difficulty to swallow tablets, all factors that could be overcome using the adaptable nature of 3DP. User acceptability studies of 3D printed formulations have been previously carried out in adults; however, feedback from children themselves is essential in establishing the quality target product profile towards the development of age-appropriate medicines. The aim of this study was to investigate the preference of children for different 3D printed tablets (Printlets™) as an important precursor to patient acceptability studies. Four different 3DP technologies; digital light processing (DLP), selective laser sintering (SLS), semi-solid extrusion (SSE) and fused deposition modeling (FDM) were used to prepare placebo printlets with similar physical attributes including size and shape. A single-site, two-part survey was completed with participants aged 4–11 years to determine their preference and opinions based on visual inspection of the printlets. A total of 368 participants completed an individual open questionnaire to visually select the best and worst printlet, and 310 participants completed further non-compulsory open questions to elaborate on their choices. Overall, the DLP printlets were the most visually appealing to the children (61.7%) followed by the SLS printlets (21.2%), and with both the FDM (5.4%) and SSE (11.7%) printlets receiving the lowest scores. However, after being informed that the SSE printlets were chewable, the majority of participants changed their selection and favoured this printlet, despite their original choice, in line with children’s preference towards chewable dosage forms. Participant age and sex displayed no significant differences in printlet selection. Printlet descriptions were grouped into four distinct categories; appearance, perceived taste, texture and familiarity, and were found to be equally important when creating a quality target product profile for paediatric 3D printed formulations. This study is the first to investigate children’s perceptions of printlets, and the findings aim to provide guidance for further development of paediatric-appropriate medicines using different 3DP technologies.
Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations
Authors: Lozzi Flavia , Di Raimondo Cosimo , Lanna Caterina , Diluvio Laura , Mazzilli Sara , Garofalo Virginia , Dika Emi , Dellambra Elena , Coniglione Filadelfo , Bianchi Luca , Campione Elena
Published: November 2020

Photosensitivity induced by drugs is a widely experienced problem, concerning both molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent one of the most common drug adverse events and are frequently an important issue to consider in the therapeutic management of patients. Phototoxicity and photoallergy are the two different pathogenic mechanisms involved in photosensitization. Related cutaneous manifestations are heterogeneous, depending on the culprit drug and subject susceptibility. Here we report an updated review of the literature with respect to pathogenic mechanisms of photosensitivity, clinical manifestations, patient management, and prediction and evaluation of drug-induced photosensitivity. We present and discuss principal groups of photosensitizing drugs (antimicrobials, nonsteroidal anti-inflammatory drugs, anti-hypertensives, anti-arrhythmics, cholesterol, and glycemia-lowering agents, psychotropic drugs, chemotherapeutics, etc.) and their main damage mechanisms according to recent evidence. The link between the drug and the cutaneous manifestation is not always clear; more investigations would be helpful to better predict drug photosensitizing potential, prevent and manage cutaneous adverse events and find the most appropriate alternative therapeutic strategy.
Effects of Grafting on Morphophysiological and Yield Characteristic of Eggplant (Solanum melongena L.) Grafted onto Wild Relative Rootstocks
Authors: Musa Ibrahim , Rafii Mohd Y. , Ahmad Khairulmazmi , Ramlee Shairul Izan , Md Hatta Muhammad Asyraf , Oladosu Yusuff , Muhammad Isma’ila , Chukwu Samuel Chibuike , Mat Sulaiman Nur Nadzirah , Ayanda Arolu Fatai , Halidu Jamilu
Published: November 2020

Grafting is regarded as an integral component of sustainable vegetable production. It is important in the management of soil-borne diseases, and reports suggest that grafting with viable rootstocks can enhance crop growth and yield. This research was conducted using splices and cleft grafting techniques to investigate graft compatibility among varieties of high yielding eggplant scion (MCV1, MCV2, CCV1, CCV2, CCV3, NCV, and TCV) grafted onto wild rootstocks (MWR, BWR, and TWR) to study their morphophysiological and yield characteristics. High yielding scions grafted onto wild relative rootstocks were compared with two controls including self-grafted and non-grafted. All the scion had a high rate of germination (≥95%) and remarkable graft success (100%) was recorded in MCV1, MCV2, and TCV using the cleft techniques. Generally, the use of rootstocks resulted in higher total and marketable fruit yield compared to the non-grafted and self-grafted scion plants, respectively. In particular, MWR and TWR rootstock conferred the highest vigour to the scion, resulting in the highest values recorded for total and marketable fruit yield, number of fruits per plant and average fruit weight. A similar result was obtained in fruit length and diameter, where long and wide fruits were observed in scions grafted onto MWR and TWR rootstocks, respectively. Grafting of high yielding eggplant scion onto resistant MWR, BWR and TWR eggplant rootstock was found to be beneficial for eggplant cultivation. The remarkable compatibility and vigour of the rootstock with scion led to the improvement in total and marketable yield of the fruits. As such, it can be concluded that the use of wild relative rootstocks of eggplant species can be a valuable method of improving eggplant production.
Evaluation of the Antiwrinkle Activity of Enriched Isatidis Folium Extract and an HPLC–UV Method for the Quality Control of Its Cream Products
Authors: Gao Dan , Cho Chong Woon , Kim Cheong Taek , Jeong Won Seok , Kang Jong Seong
Published: November 2020

Currently, many extracts from natural sources are added to cosmetic products for reducing facial aging and wrinkles. This study investigated the antiwrinkle activity of enriched extract of Isatidis Folium used for a novel antiwrinkle cream product. The result demonstrated that this enriched extract has excellent antiwrinkle activity by significantly inhibiting mRNA expression of matrix metalloproteinase-1, matrix metalloproteinase-3, and pro-inflammatory cytokines IL-1β and upregulating the mRNA expression of IL-4 and procollagen. Additionally, to implement effective quality control of the entire manufacturing process of antiwrinkle cream products based on the enriched extract of Isatidis Folium, the main chemical constituents of the enriched extract of Isatidis Folium was evaluated by high–performance liquid chromatography-photodiode array-tandem mass spectrometry (HPLC-PDA-ESI-MS/MS), five constituents were undisputedly confirmed. An HPLC-UV method in 15-min analysis time for quality assessment of the entire manufacturing process of antiwrinkle cream products was proposed and validated. The optimal conditions for extracting TMCA (3,4,5-trimethoxycinnamic acid) from the developed antiwrinkle cream products were determined using response surface methodology based on central composite design. The established HPLC method and optimal extract condition are suitable for routinely analyzing this novel antiwrinkle cream product.
Agro-Techniques for Lodging Stress Management in Maize-Soybean Intercropping System—A Review
Authors: Raza Ali , Asghar Muhammad Ahsan , Ahmad Bushra , Bin Cheng , Iftikhar Hussain M. , Li Wang , Iqbal Tauseef , Yaseen Muhammad , Shafiq Iram , Yi Zhang , Ahmad Irshan , Yang Wenyu , Weiguo Liu
Published: November 2020

Lodging is one of the most chronic restraints of the maize-soybean intercropping system, which causes a serious threat to agriculture development and sustainability. In the maize-soybean intercropping system, shade is a major causative agent that is triggered by the higher stem length of a maize plant. Many morphological and anatomical characteristics are involved in the lodging phenomenon, along with the chemical configuration of the stem. Due to maize shading, soybean stem evolves the shade avoidance response and resulting in the stem elongation that leads to severe lodging stress. However, the major agro-techniques that are required to explore the lodging stress in the maize-soybean intercropping system for sustainable agriculture have not been precisely elucidated yet. Therefore, the present review is tempted to compare the conceptual insights with preceding published researches and proposed the important techniques which could be applied to overcome the devastating effects of lodging. We further explored that, lodging stress management is dependent on multiple approaches such as agronomical, chemical and genetics which could be helpful to reduce the lodging threats in the maize-soybean intercropping system. Nonetheless, many queries needed to explicate the complex phenomenon of lodging. Henceforth, the agronomists, physiologists, molecular actors and breeders require further exploration to fix this challenging problem.
The Woody Planet: From Past Triumph to Manmade Decline
Authors: Fazan Laurence , Song Yi-Gang , Kozlowski Gregor
Published: November 2020

Woodiness evolved in land plants approximately 400 Mya, and very soon after this evolutionary invention, enormous terrestrial surfaces on Earth were covered by dense and luxurious forests. Forests store close to 80% of the biosphere’s biomass, and more than 60% of the global biomass is made of wood (trunks, branches and roots). Among the total number of ca. 374,000 plant species worldwide, approximately 45% (138,500) are woody species—e.g., trees, shrubs or lianas. Furthermore, among all 453 described vascular plant families, 191 are entirely woody (42%). However, recent estimations demonstrate that the woody domination of our planet was even greater before the development of human civilization: 1.4 trillion trees, comprising more than 45% of forest biomass, and 35% of forest cover disappeared during the last few thousands of years of human dominance on our planet. The decline in the woody cover of Planet Earth did not decelerate during the last few centuries or decades. Ongoing overexploitation, land use and climate change have pushed ten thousand woody species to the brink of extinction. Our review highlights the importance, origin and past triumph of woody species and summarizes the unprecedented recent decline in woody species on our planet.
Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems
Authors: Ailincai Daniela , Porzio William , Marin Luminita
Published: November 2020

This paper reports new formulations based on chitosan, citral, and diclofenac sodium salt (DCF). The central idea was to encapsulate an anionic drug into a polycationic hydrogel matrix in order to increase the intermolecular forces between them and thus to ensure slower drug release, while citral was used as a penetration enhancer to assure efficient delivery of the drug. Hydrogels without drug were also synthesized and used as a reference. The structure, morphology, and supramolecular architecture of the drug delivery systems were evaluated by FTIR spectroscopy, scanning electron microscopy, polarized optical microscopy, and wide-angle X-ray diffraction. The drug release kinetics was monitored in vitro by UV-VIS spectroscopy, in physiological conditions, while the enzymatic and hydrolytic degradability of the hydrogels were evaluated in the presence of lysozyme and phosphate buffer saline (PBS), at 37 °C. All of the data revealed that the anionic DCF was strongly anchored into the polycationic matrix and the drug was slowly released over 7 days. Moreover, the release rate can be controlled by simple variation of the molar ratio between the polycationic chitosan and lipophilic citral.
Biopolymeric Delivery Systems for Cosmetic Applications Using Chlorella vulgaris Algae and Tea Tree Essential Oil
Authors: Morais Flávia P. , Simões Rogério M. S. , Curto Joana M. R.
Published: November 2020

Cosmetic products in which all the skincare compounds are biomolecules, biocompatible and biodegradable constitute a request of an educated consumer corresponding to a premium cosmetic segment. For this purpose, a cellulose-based delivery system was developed to retain biomolecules for dermic applications. The 3D matrix was built with microfibrillated cellulose, nanofibrillated cellulose and carboxymethylcellulose combined with a crosslinking agent, the alginate, to obtain a 3D matrix capable of retaining and releasing bioactive components of microalgae Chlorella vulgaris and tea tree essential oil. The porosity and pore dimensions and uniformity of this support matrix were optimized using 3D computational tools. The structures of the biopolymers were characterized using SEM, EDX, FTIR-ATR and DSC techniques. The essential oil and the microalgae components were successfully incorporated in a 3D stable matrix. The results indicate that the polymeric matrix retains and releases the essential oil biomolecules in a controlled way, when compared with tea tree essential oil, which is vaporized from 25 °C to 38 °C, without this 3D polymeric matrix. The microalgae and cellulose-based delivery system proved to be an interesting option for dermic and cosmetic applications because the exposure time of the therapeutic biomolecules was improved, and this factor consists of a competitive benefit for dermic systems.
Prediction of Ultimate Strain for Rectangular Reinforced Concrete Columns Confined with Fiber Reinforced Polymers under Cyclic Axial Compression
Authors: Fanaradelli Theodora D. , Rousakis Theodoros C.
Published: November 2020

This paper investigates the crucial design parameters for the prediction of the ultimate axial compressive deformation of reinforced concrete columns externally confined with fiber reinforced polymer (FRP) materials. Numerous test results of available columns with a square and rectangular section under cyclic axial loading were gathered in an advanced database. Herein, the database is enriched with necessary design parameters in order to address the unique tensile strain field variation of the FRP jacket. Since there is a lack of consequent recording of the FRP strain field in existing experiments, three dimensional pseudodynamic finite element analyses results from several characteristic cases of tested columns are utilized to address this gap. Therefore, a hybrid experimental–analytical database is formed, including several critical FRP strains, steel strains and deformations. A modified model is proposed to predict the ultimate axial strain for reinforced concrete columns externally confined with FRP materials. The proposed model aims to address indirectly the effects of the internal steel cage, concrete section shape and of their interaction with the external FRP jacket on the critical tensile strain of the FRP jacket at failure of the column. The predictive performance of the model over the available tests of (reinforced concrete) RC columns under cyclic compression is remarkably improved when compared against the performance of other existing models. It provides predictions with average ratio (AR) of 0.96 and average absolute error (AAE) of 36.5% and therefore may contribute to safer seismic resistant redesign.
Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications
Authors: Bashir Shahid , Hina Maryam , Iqbal Javed , Rajpar A. H. , Mujtaba M. A. , Alghamdi N. A. , Wageh S. , Ramesh K. , Ramesh S.
Published: November 2020

In the present review, we focused on the fundamental concepts of hydrogels—classification, the polymers involved, synthesis methods, types of hydrogels, properties, and applications of the hydrogel. Hydrogels can be synthesized from natural polymers, synthetic polymers, polymerizable synthetic monomers, and a combination of natural and synthetic polymers. Synthesis of hydrogels involves physical, chemical, and hybrid bonding. The bonding is formed via different routes, such as solution casting, solution mixing, bulk polymerization, free radical mechanism, radiation method, and interpenetrating network formation. The synthesized hydrogels have significant properties, such as mechanical strength, biocompatibility, biodegradability, swellability, and stimuli sensitivity. These properties are substantial for electrochemical and biomedical applications. Furthermore, this review emphasizes flexible and self-healable hydrogels as electrolytes for energy storage and energy conversion applications. Insufficient adhesiveness (less interfacial interaction) between electrodes and electrolytes and mechanical strength pose serious challenges, such as delamination of the supercapacitors, batteries, and solar cells. Owing to smart and aqueous hydrogels, robust mechanical strength, adhesiveness, stretchability, strain sensitivity, and self-healability are the critical factors that can identify the reliability and robustness of the energy storage and conversion devices. These devices are highly efficient and convenient for smart, light-weight, foldable electronics and modern pollution-free transportation in the current decade.
Is it Possible to Mechanical Recycle the Materials of the Disposable Filtering Masks?
Authors: Battegazzore Daniele , Cravero Fulvia , Frache Alberto
Published: November 2020

In a singular period, such as during a pandemic, the use of personal protective masks can become mandatory for all citizens in many places worldwide. The most used device is the disposable mask that, inevitably, generates a substantial waste flow to send to incineration or landfill. The article examines the most diffused type of disposable face mask and identifies the characteristic of the constituent materials through morphological, chemical, physical, and thermal analyses. Based on these investigations, a mechanical recycling protocol with different approaches is proposed. Advantages and disadvantages of the different recycling solutions are discussed with considerations on necessary separation processes and other treatments. The four solutions investigated lead to a recycling index from 78 to 91% of the starting disposable mask weight. The rheological, mechanical, and thermo-mechanical properties of the final materials obtained from the different recycling approaches are compared with each other and with solutions present on the market resulting in materials potentially industrially exploitable.
Enhancement of Biomass and Lipid Productivities of Scenedesmus sp. Cultivated in the Wastewater of the Dairy Industry
Authors: Mercado Ingrid , Álvarez Xavier , Verduga María-Eloiza , Cruz Andrea
Published: November 2020

Microalgae are photoautotrophic microorganisms capable of producing compounds with potential bioenergetic applications as an alternative energy source due to the imminent exhaustion of fossil fuels, their impact on the environment, and the constant population increase. The mass cultivation of these microorganisms requires high concentrations of nutrients, which is not profitable if analytical grade culture media are used. A viable alternative is the use of agro-industrial wastewater, due to the metabolic flexibility of these microorganisms and their ability to take advantage of the nutrients present in these substrates. For the reasons mentioned above, the effect of the cultivation in wastewater from cheese processing on the growth parameters and biomass composition of Scenedesmus sp. was evaluated, and its nutrient removal capacity determined. A high lipid concentration was obtained in the cultures with the dairy effluent (507.81 ± 19.09 mg g−1) compared to the standard culture medium, while the growth parameters remained similar to the control medium. Scenedesmus sp. achieved high percentages of nutrient assimilation of the wastewater used (88.41% and 97.07% for nitrogen and phosphorus, respectively). With the results obtained, the feasibility of cultivating microalgae in agro-industrial wastewater as an alternative culture medium that induces the accumulation of compounds with potential bioenergetic applications was verified.
Alcohol Dehydration by Extractive Distillation with Use of Aminoethers of Boric Acid
Authors: Klinov Alexander V. , Malygin Alexander V. , Khairullina Alina R. , Dulmaev Sergey E. , Davletbaeva Ilsiya M.
Published: November 2020

Aminoethers of boric acid (AEBA) were studied as potential extractants for the separation of aqueous–alcoholic azeotropic mixtures by extractive distillation. The conditions of vapor–liquid equilibrium in aqueous solutions of ethanol and isopropanol in the presence of AEBA were studied. The division of AEBA molecules into group components was proposed, and previously unknown geometric parameters of the boron group and the energetic pair parameters of the boron group with the alkane group, ether group, amine-3d group, and alcohol group were determined within the framework of the Universal Functional Group Activity Coefficient (UNIFAC) model. The modeling of the extractive rectification process of an ethanol–water mixture with AEBA as extractant has been carried out. The dependences of the cost function on the extractant flow rate, the residual water content in it and the number of theoretical trays were obtained. A technological scheme for ethanol dehydration has been proposed, and its technological characteristics have been calculated.
NOx Emission Reduction by Advanced Reburning in Grate-Rotary Kiln for the Iron Ore Pelletizing Production
Authors: Hu Bing , Hu Peiwei , Lu Biao , Xie Zhicheng , Liu Liu , Cheng Gangli , Wei Jiaoyang
Published: November 2020

The NOx reduction in the iron ore pelletizing process becomes an important environmental concern owing to its role in the formation of photochemical smog and acid rain. Thus, it is essential to develop new technologies for reducing NOx emissions in order to contribute to the cleaner production of pellets. In this paper, NOx reduction by advanced reburning ingrate-rotary kiln for oxidized pellet production was performed on a laboratory-scale gas kiln. Temperature and NH3/NOx molar ratio (NSR) were the key factors affecting the reduction of NOx. A better denitrification effect can be obtained on flus gas with higher initial NOx concentration, at temperature = 900 °C, NSR = 1.2, and reaction time exceeds one second. NOx reduction rate had reached 55–65% when the initial NOx concentration was above 400 ppm, and exceeds 70% when the initial NOx concentration was around 680 ppm. Urea solution has the best denitrification effect compared with NH3·H2O and NH4HCO3 solution. As for additives, the denitrification effect of the vanadium-titanium catalyst was better than that of ethanol and NaCl, while NaCl plays a promotive role at low NSR. Finally, a series of denitrification measures that include advanced reburning technology for achieving NOx ultra-low emission in the oxidation pellet production was proposed.
Analysis of Dynamic Engaged Characteristics of Wet Clutch in Variable Speed Transmission of a Helicopter
Authors: Bao Heyun , Xu Tongjing , Jin Guanghu , Huang Wei
Published: November 2020

The working principle and motion process of an aviation wet clutch are analyzed. The initial velocity before the friction pair engaged is solved. The transient Reynolds equation is modified, and an oil film bearing capacity model and a micro-convex bearing capacity model are derived. The film thickness equation between N friction pairs and a pressure-plate is derived. A dynamic engaged model of springs, pistons, friction pairs, and pressure plates are established. The torque balance equation is established of two pairs of friction pairs. The friction torque, rate of change in the oil film, and law of relative change in speed are obtained. The results demonstrate that the spring preload and the viscosity of the lubricating oil have a significant influence on the engagement characteristics. Increasing the quality of the friction plate will reduce the time of engagement, whereas the quality of the friction plate has slight effect on the friction torque characteristics and oil film thickness. The initial speed generated by the collision process will reduce the output speed, sharply increase the torque peak at the lock, and increase the shift shock.
Functional Polymer Hybrid Nanocomposites Based on Polyolefins: A Review
Authors: Paszkiewicz Sandra , Pypeć Krzysztof , Irska Izabela , Piesowicz Elzbieta
Published: November 2020

For the last twenty years, polymer hybrid nanocomposites have enjoyed unflagging interest from numerous scientific groups and R&D departments, as they provide notable enhancement of properties, even at low nanofillers’ content. Their performance results from many factors, the most important of which is the uniform distribution in the entire volume of the matrix, that still is very challenging, but is the right choice of two types of nanoparticles that can lead to an increase of dispersion stability and even more uniform distribution of fillers. The incorporation of two types of nanofillers, especially when they differ in aspect ratio or chemical nature, allows to additively reduce the price of the final composite by replacing the more expensive filler with the cheaper one, or even synergistically improving the properties, e.g., mechanical, thermal, and barrier, etc., that can extend their usage in the industry. Despite numerous review papers on nanocomposites, there is no review on how the introduction of a hybrid system of nanofillers affects the properties of polyolefins, which are the most commonly used engineering plastics. This review deeply focuses on the structure–properties relationship of polyolefins-based hybrid nanocomposites, especially based on two types of polyethylenes (low-density polyethylenes (LDPE) and high-density polyethylenes (HDPE)) and polypropylene.
Cobalt Catalyst Reduction Thermodynamics in Fischer Tropsch: An Attainable Region Approach
Authors: Gorimbo Joshua , Muvhiiwa Ralph , Llane Ephraim , Hildebrandt Diane
Published: November 2020

A fundamental understanding of the precise reduction reaction pathway of cobalt-based catalysts is a crucial piece of knowledge in terms of the Fischer–Tropsch Synthesis (FTS) reaction. The use of hydrogen (H2) as the reduction agent results in a two-stage reduction of cobalt tetraoxide (Co3O4) to cobalt oxide (CoO) and then to metallic Co. The objective of the present work is to apply the Thermodynamic Attainable Region (TAR) to cobalt catalyst reduction using H2 so as to gain better insight regarding the thermodynamics of reduction reaction. TAR space diagrams suggest that complete Co3O4 reduction is feasible through two reaction pathways. Thus, the observed AR results suggest that the temperature programmed reduction’s (TPR) first reaction peak may be attributed to direct reduction of Co3O4 → Co and/or reduction to an intermediate compound Co3O4 → CoO. The second peak is a result of the reduction of either of the cobalt oxides to Co (Co3O4 → Co or CoO → Co).
Religious Education in (Post-)Pandemic Times; Becoming a Resilient Professional in a Teacher Academy
Authors: van Dijk-Groeneboer Monique
Published: November 2020

The world seems a different place than it was before and now, more than ever, young people are faced with questions that cannot be avoided any longer: who am I? How and where can I find roots to endure the storms in my life? In what direction should I steer my compass? These questions are about resilience; the ability of individuals to cope with rapid societal change, both in their personal lives and in their professional career. Religious Education (RE) can help pupils and students to develop resilience by articulating these questions and pursuing them. The RE teacher’s job is to simply be there with them, having considered these questions her- or himself. All teachers and educators have to start with their own reflection: who am I as an RE-teacher in this new, uncertain and rapidly transforming world? Research on how to start this reflective formation process in RE is essential to attracting the attention that RE deserves. In this article, examples of pilots and the research conducted on them in the author’s Teacher Academy are presented. The main goal is to contribute to the formation of young people to make them resilient and fit for the -as yet unknown- future. They have to create this future and use their talents to effect the transformation that our world highly needs.
Future-Day Saints: Abrahamic Astronomy, Anthropological Futures, and Speculative Religion
Authors: Bialecki Jon
Published: November 2020

In the Church of Jesus Christ of Latter-day Saints, there is an intense interest in creating “speculative fiction”, including speculative fiction about outer space. This article ties this interest to a broader tradition of “speculative religion” by discussing the Mormon Transhumanist Association. An interest in outer space is linked to nineteenth and twentieth-century speculation by Mormon intellectuals and Church leaders regarding “Abrahamic Astronomy”. The article suggests that there is a Mormon view of the future as informed by a fractal or recursive past that social science in general, and anthropology in particular, could use in “thinking the future”.
Images of the Mother Goddess in the Neolithic Sanctuary of Pla de Petracos (Alicante, Spain)—The Sacralization of Agriculture
Authors: Roche Cárcel Juan Antonio
Published: November 2020

The objective of this work is to iconologically analyze the cave paintings of the Neolithic sanctuary of Pla de Petracos (Alicante, Spain), putting them in relation to the way of life and the religious thought of the society of the time, as well as the connection of these paintings with the Mother Goddess. To do this, firstly, the characters of early Neolithic agricultural and livestock societies, and the religiosity of the Mother Goddess that she professes, are contextualized with abundant academic documentation. The natural and religious scenery of the territory where the images and material goods—cardial ceramics, musical instruments, and ritual objects—excavated in the archeological sites located in the surroundings are described below. Finally, significant examples of ancient cultures related to the sanctuary are offered.
Elevation Changes of the Antarctic Ice Sheet from Joint Envisat and CryoSat-2 Radar Altimetry
Authors: Zhang Baojun , Wang Zemin , Yang Quanming , Liu Jingbin , An Jiachun , Li Fei , Liu Tingting , Geng Hong
Published: November 2020

The elevation changes of ice sheets have been recognized as an essential climate variable. Long-term time series of these changes are an important parameter to understand climate change, and the longest time-series of ice sheet elevation changes can be derived from combining multiple Ku-band satellite altimetry missions. However, unresolved intermission biases obscure the record. Here, we revise the mathematical model commonly used in the literature to simultaneously correct for intermission bias and ascending–descending bias to ensure the self-consistency and cohesion of the elevation time series across missions. This updated approach is applied to combine Envisat and CryoSat-2 radar altimetry in the period of 2002–2019. We tested this approach by validating it against airborne and satellite laser altimetry. Combining the detailed temporal and spatial evolution of elevation changes with firn densification-modeled volume changes due to surface processes, we found that the Amundsen Sea sector accounts for most of the total volume loss of the Antarctic Ice Sheet (AIS), mainly from ice dynamics. However, surface processes dominate the volume changes in the key regions, such as the Totten Glacier sector, Dronning Maud Land, Princess Elizabeth Land, and the Bellingshausen Sea sector. Overall, accelerated volume loss in the West Antarctic continues to outpace the gains observed in the East Antarctic. The total volume change during 2002–2019 for the AIS was −68.7 ± 8.1 km3/y, with an acceleration of −5.5 ± 0.9 km3/y2.
Editorial for the Special Issue: Assessment of Renewable Energy Resources with Remote Sensing
Authors: Martins Fernando Ramos
Published: November 2020

The development of renewable energy sources plays a fundamental role in the transition towards a low carbon economy. Considering that renewable energy resources have an intrinsic relationship with meteorological conditions and climate patterns, methodologies based on the remote sensing of the atmosphere are fundamental sources of information to support the energy sector in planning and operation procedures. This Special Issue is intended to provide a highly recognized international forum to present recent advances in remote sensing to data acquisition required by the energy sector. After a review, a total of eleven papers were accepted for publication. The contributions focus on solar, wind, and geothermal energy resource. This editorial presents a brief overview of each contribution.
Turbidity Estimation from GOCI Satellite Data in the Turbid Estuaries of China’s Coast
Authors: Feng Jiangang , Chen Huangrong , Zhang Hailong , Li Zhaoxin , Yu Yang , Zhang Yuanzhi , Bilal Muhammad , Qiu Zhongfeng
Published: November 2020

Knowledge of the distribution and variation of water turbidity directly represent important information related to the marine ecology and multiple biogeochemical processes, including sediment transport and resuspension and heat transfer in the upper water layer. In this study, a neural network (NN) approach was applied to derive the water turbidity using the geostationary ocean color imager (GOCI) data in turbid estuaries of the Yellow River and the Yangtze River. The results showed a good agreement between the GOCI-derived turbidity and in situ measured data with a determination coefficient (R2) of 0.84, root mean squared error (RMSE) of 58.8 nephelometric turbidity unit (NTU), mean absolute error of 25.1 NTU, and mean relative error of 34.4%, showing a better performance than existing empirical algorithms. The hourly spatial distributions of water turbidity in April 2018 suggested that high turbidity regions were distributed in the Yellow River estuary, Yangtze River estuary, Hangzhou Bay, and coastal waters of Zhejiang Province. Furthermore, the relationship between water turbidity and tide were estimated. A defined turbid zone was defined to evaluate the diurnal variations of turbidity, which has subtle changes at different times. Our results showed an inverse relationship between turbidity and tide over six selected stations, i.e., when the value of turbidity is high, then the corresponding tidal height is usually low, and vice versa. The combined effects of tidal height and tidal currents could explain the phenomena, and other factors such as winds also contribute to the turbidity distributions.
An Effective High Spatiotemporal Resolution NDVI Fusion Model Based on Histogram Clustering
Authors: Xing Xuegang , Yan Changzhen , Jia Yanyan , Jia Haowei , Lu Junfeng , Luo Guangjie
Published: November 2020

The normalized difference vegetation index (NDVI) is a powerful tool for understanding past vegetation, monitoring the current state, and predicting its future. Due to technological and budget limitations, the existing global NDVI time-series data cannot simultaneously meet the needs of high spatial and temporal resolution. This study proposes a high spatiotemporal resolution NDVI fusion model based on histogram clustering (NDVI_FMHC), which uses a new spatiotemporal fusion framework to predict phenological and shape changes. Meanwhile, this model also uses four strategies to reduce error, including the construction of an overdetermined linear mixed model, multiscale prediction, residual distribution, and Gaussian filtering. Five groups of real MODIS_NDVI and Landsat_NDVI datasets were used to verify the predictive performance of the NDVI_FMHC. The results indicate that NDVI_FMHC has higher accuracy and robustness in forest areas (r = 0.9488 and ADD = 0.0229) and cultivated land areas (r = 0.9493 and ADD = 0.0605), while the prediction effect is relatively weak in areas subject to shape changes, such as flooded areas (r = 0.8450 and ADD = 0.0968), urban areas (r = 0.8855 and ADD = 0.0756), and fire areas (r = 0.8417 and ADD = 0.0749). Compared with ESTARFM, NDVI_LMGM, and FSDAF, NDVI_FMHC has the highest prediction accuracy, the best spatial detail retention, and the strongest ability to capture shape changes. Therefore, the NDVI_FMHC can obtain NDVI time-series data with high spatiotemporal resolution, which can be used to realize long-term land surface dynamic process research in a complex environment.
Resolving and Analyzing Landfast Ice Deformation by InSAR Technology Combined with Sentinel-1A Ascending and Descending Orbits Data
Authors: Wang Zhiyong , Liu Jian , Wang Jinning , Wang Lihua , Luo Meng , Wang Zihao , Ni Ping , Li Hao
Published: November 2020

Detailed mapping of landfast ice deformation can be used to characterize the rheological behavior of landfast ice effectively and to improve sea ice modeling subsequently. In order to analyze the characteristics, trends and causes of deformation comprehensively and accurately, the Sentinel-1A ascending and descending orbits data were used to detect the horizontal and vertical deformation of the fast ice in the Baltic Sea. Firstly, the fast ice edge lines were acquired through feature extraction with interferometric coherence images and SAR amplitude images. Then, the deformation transformed model was constructed according to the geometric relationship of multi-orbits deformation measurements. Finally, the landfast ice deformations were resolved and the horizontal and vertical deformations were obtained. The results showed that the maximum deformation was—44 cm in horizontal direction and 16 cm in vertical direction within the fast ice region of 960 km2 during the time from 2 to 16 February 2018. The southwest wind was the principal reason for the deformation, which made the deformation mainly occur in the horizontal direction from east to west. Moreover, the inner fast ice kept stable due to the protection of outer consolidated ice. The results showed that the deformation trend and characteristics can be better understood by using InSAR technology that was combined with multi-orbits SAR data to resolve and analyze the landfast ice deformation.