bluuebunny/crossref_metadata_2025 huggingface dataset:
PERBEDAAN MOTIVASI BELAJAR SISWA MENGGUNAKAN MEDIA GAMBAR DENGAN LINGKUNGAN SEKITAR SEBAGAI MEDIA PEMBELAJARAN PADA MATA PELAJARAN IPA SISWA KELAS IV SDN 8 MIMBAAN KECAMATAN PANJI KABUPATEN SITUBONDO TAHUN AJARAN 2020/2021
Authors: Setiawan Gustilas Ade , Lestari Maulita
Published: October 2023

Motivasi merupakan salah satu aspek yang diperlukan untuk membentuk kepribadian siswa dan untuk meningkatkan motivasi belajar siswa. Oleh karena itu, permasalahan penelitian ini sampai pada pertanyaan “adakah perbedaan motivasi belajar terhadap media pembelajaran?”. Penelitian ini dilakukan di SDN 8 Mimbaan kelas IV dengan jumlah siswa 50 orang yang menggunakan media gambar dan lingkungan sekitar. Penelitian ini merupakan penelitian kuantitatif. Dalam tinjauan teori, Media adalah perantara atau penyampai pesan dari pengirim kepada penerima. Media dapat dibedakan menjadi media gambar dan media lingkungan sekitar yang membantu proses pembelajaran. Media gambar merupakan alat yang diwujudkan secara visual dalam dua dimensi. Hal ini dapat digunakan untuk membantu peserta didik untuk mencapai tujuan pembelajaran. Media pembelajaran dapat terbentuk dari lingkungan, seperti: lingkungan sosial, lingkungan alam, dan lingkungan buatan. Masing-masing media memiliki kelebihan dan kekurangan. Ini memiliki fungsinya sendiri. Data dianalisis menggunakan uji normalitas, homogenitas, dan hipotesis. Hasil perhitungan statistik menunjukkan adanya perbedaan motivasi belajar siswa yang menggunakan media gambar dan media lingkungan sekitar sebagai media pembelajaran IPA kelas IV di SDN 8 Kecamatan Mimbaan Panji Kabupaten Situbondo. Hasilnya Thitung = 4,351 dan Ttabel = 2,011. Berdasarkan hasil uji statistik, penerapan media lingkungan sekitar lebih efektif dan signifikan dibandingkan dengan media gambar, meskipun media pembelajaran menggunakan standar kompetensi (SK) dan kompetensi dasar (KD) yang sama.
MENINGKATKAN HASIL BELAJAR MATEMATIKA MELALUI METODE PENEMUAN TERBIMBING (GUIDED DISCOVERY) SISWA KELAS IV DI SD NEGERI 3 PLALANGAN SEMESTER I
Authors: Setyorini Indah Lestari , Pratiwi Vidya , Hidayat Rahmat
Published: October 2023

Ketepatan penggunaan suatu metode akan menunjukkan fungsionalnya strategi dalam kegiatan  pembelajaran.  Metode  pembelajaran  jenisnya  beragam  yang  masing  – masing memiliki kelebihan dan kelemahan, maka pemilihan metode yang sesuai dengan topik yang diajarkan harus betul – betul difikirkan guru yang akan menyampaikan materi pelajaran dengan KKM 65 secara individual. Berdasarkan uraian latar belakang masalah, penelitian ini dirumuskan sebagai berikut : 1) Bagaimanakah penerapan metode penemuan terbimbing (guided discovery) dapat meningkatkan hasil belajar siswa ? dan 2) Apakah metode penemuan terbimbing (guided discovery) dapat meningkatkan hasil belajar siswa ?. Jenis penelitian tindakan ini termasuk penelitian tindakan kelas. Tempat penelitian adalah di SD Negeri 3 Plalangan. Penelitian ini terdiri atas empat fase yaitu observasi, wawancara, dokumentasi dan tes. Analisa data dalam penelitian ini menggunakan analisis deskriptif kualitatif. Bahwa dapat disimpulkan sebagai berikut: Penerapan metode penemuan terbimbing (guided discovery) dapat meningkan hasil belajar siswa. Ada peningkatan hasil belajar mencapai 20% dari 60% siklus I menjadi 80% siklus II melalui metode penemuan terbimbing (guided discovery).
Supply Chain Risk Management - A Review
Authors: - Shivam Singh
Published: October 2023

Supply chain risk management (SCRM) is pivotal in contemporary business operations, especially amid global disruptions like the COVID-19 pandemic. This abstract provides a synthesis of six research studies encompassing various facets of SCRM
EduTube : Enhancing Credibility and User Experience in Online Learning
Authors: - Rahul Bothra , - Deon Gracias , - Vijay Prajapati , - Sujata Deshmukh
Published: October 2023

EduTube addresses a common challenge in online learning: the lack of credibility associated with YouTube tutorials. Recognizing that many learners rely on YouTube due to cost constraints, we've created an interactive mobile application. This AI-powered platform enhances credibility by offering dynamic quizzes generated from video subtitles through NLP. Users can add YouTube playlists, pending admin approval, and complete quizzes after each video. They can also explore playlists from other users. Any reported inaccuracies are promptly investigated. Upon successful completion, users receive a certification, providing tangible proof of their knowledge and enhancing their employability. EduTube bridges the gap between accessible learning and verifiable skills attainment.
Greenhouse Technology for Controlled Environment Crop Production
Authors: - Mr. Pawan Raj Badu
Published: October 2023

Greenhouse technology has emerged as a pivotal solution for revolutionizing modern crop production by creating controlled environments. This study delves into the multidimensional realm of greenhouse technology and its significant impact on agricultural practices. The overview comprehensively discusses the importance, advantages, and challenges of controlled environment crop production within greenhouses. It also highlights the innovative and sustainable development potential of this technology in the agricultural sector. The investigation primarily focuses on precise climate control, resource efficiency, crop diversification, and urban agriculture, shedding light on how research and development will shape the future of greenhouse-based crop cultivation. Furthermore, the adaptability of greenhouse environments empowers growers to diversify their crop portfolios beyond the constraints of traditional growing seasons, ensuring a stable food supply and bolstering agricultural resilience in the face of shifting climate patterns.
Revolutionizing Authentication: Google Passkeys Technology
Authors: - Sudershan Manasvi Malhar
Published: October 2023

In the ever-evolving landscape of digital security, the traditional methods of authentication are facing increasing challenges in safeguarding sensitive information and user privacy. Google Passkeys technology emerges as a pioneering solution poised to redefine the way users access their accounts and protect their digital identities.

This abstract delves into the innovation of Google Passkeys technology, exploring its fundamental principles and potential impact. Passkeys represent a paradigm shift in authentication by eliminating the need for passwords, which have long been susceptible to breaches and often result in user frustration. Instead, Passkeys harness cutting-edge cryptographic techniques to create a seamless and secure authentication process.

At its core, Google Passkeys rely on a unique combination of hardware-based security keys and advanced cryptographic algorithms. Users are equipped with physical security keys, such as USB tokens or smartphones with built-in security features, which act as the "key" to their digital identities. These keys, paired with secure communication protocols, provide a multifaceted approach to authentication that significantly enhances security.
The Influence of Bottom Ash Column in the Geotechnical Properties Enhancement of Soft Clay Soil
Authors: - Ng Jun Shen , - Muzamir Hasan , - Nur Amina Azmyra Hashim
Published: October 2023

The utilization of bottom ash in ground improvement studies can cut down the quantity of generated waste which is in response to environmental conservation and enhancing the soil properties. The bottom ash which plays the role of replacing the coarse aggregate like sand and gravel in upgrading the behaviour of soft clay soil can fulfill the sustainability concept in construction. For construction purposes, the soil and ground improvement activities are necessary to carry out by using the relevant techniques, including the vibro-replacement method. This method was applied which suits the limitation of this study as it was executed in the laboratory for the preparation of the bottom ash column. The properties examination of kaolin clay and bottom ash were first studied through its particle size, specific gravity, liquid and plastic limit, and compaction. The following procedure was about the column preparation process, where the column diameter was set to be constant at 20 mm throughout the study. The execution of the Unconfined Compression Test (UCT) on the Bottom Ash Column has shown its impact on the undrained shear strength upgrade and it was focused on the height of the bottom ash column built beneath the kaolin clay at 60mm, 80mm, and 100 mm. As observed from the trend, the height of the bottom ash column shows a direct proportional relationship by the undrained shear strength, ranging from 11.64% - 14.26% by using the control sample (with no bottom ash reinforcement) as reference. Conclusively, the use of bottom ash subsides the disposal waste and in no time provides support to the shear strength of soft clay soil which is sustainable and applicable.
De-industrialization and Industrialization in India during Colonial Period: An Appraisal of Theoretical Implications, Conventional Approaches and Alternative Perspective
Authors: - Ashima Saxena
Published: October 2023

This paper explores the context of different models of de-industrialization and industrialization, which connected to social structural change, by going through existing narratives, whether Marxist or functionalist, derived largely from the complex historical experiences of Western Europe, especially Britain, which is seated in our historical consciousness as a lens to examine various narratives of different geographical location in different set of time to set universal postulates. On closer examination of the Indian economy, this essay sets out shared assumptions, common to Marxism and functionalism with new recent research about the character of economic development as a social process, by unfurling the dynamism and complexities of socio-economic nature of the Indian economy, which offers some alternative perspective.
Effect of Circuit Training on Selected Motor Fitness Variables on Skill Performance of Male Mallakhamb Players
Authors: - Shonan Padte , - Aditya Gharat
Published: October 2023

A single group experimental study was conducted on 20 male mallakhamb players, from the age group below 14 years from Ruturaj Sports Academy Chinchpokli, Mumbai. The study was conducted to test the effect of circuit training programme on selected motor fitness variables of muscular endurance (abdominal strength endurance) and balance as well as skill performance of potachatajawa and veerbhadrasana on the mallakhamb of male mallakhmab players. The training was provided for 60 minutes a day during the evening session, for 3 days a week for a period of 3 months. The Circuit training was modified after every three weeks. At the end of the study the data obtained was statistcally analysed using paired t test. It was thus, concluded that the circuit training programme significantly improved the motor fitness variables of muscular endurance (abdominal strength endurance) and balance as well as positively effected the skill performance of potachatajawa and veerbhadrasana on the mallakhamb of the male mallakhmab players.
Optimization and Development of Herbal Incense Cones for Air Purification and Mosquito Repellent Trash into Treasure: Novel Low Cost Environmental Friendly Polyherbal Mosquito Repellants and Air Purifier Incense Cones
Authors: - Rashmi Bagri , - P.Poornima , - K.Nagaraja , - G.Tulja Rani
Published: October 2023

The atmosphere has been a foremost concern in today’s era. The constant pollution all around has gathered the attention of many people. Disease causing pathogens spread from an infected person and mosquitoes also spread diseases like malaria. Microbial burden of the air causes several airborne illnesses[1]. Synthetic mosquito repellent and air purifiers used to control the vectors are causing irreversible damage to ecosystem and also chemicals are carcinogenic in nature. Poly herbal incense cones are free from cancer-causing chemicals. Incense is known to impart antimicrobial activity. The objective of the current work is to formulate low cost environmental friendly polyherbal mosquito repellants and air purifier incense cones and to evaluate its activity. Public survey was also done to study safety and efficacy of the formulation. Dried powdered leaves of Piper bettle, flowers of Nyctanthes arbortristis, Artemisia pallens, Rosa rubiginosa, Tagetsarecta, Nelumbonucifera, and plant extrudes of Spyrax benzoin were mixed with Azadirechta indica oil. Linumusit atissimum and Apismellifera used as binders. Saw dust and cow dung are used for ignition. The powdered blend additional to enhance worth, it was later fragranced 1with volatile oil like Jasminum officinale and dehydrated [2]. Results shows that they have the mosquito repellant and air purifying activity. The prepared herbal mosquito incense cones are effective, safe with more duration of time and less cost.
A Review of the Magical Indian Shrub Asparagus Racemosus
Authors: - Sonam Rajput , - Upasana Kandpal , - Vijay Upadhyay , - Deepshikha Nirala , - Vipin Kushah
Published: October 2023

Asparagus racemosus a climbing Ayurvedic plant which is most an important medicinal plant of tropical and subtropical India. The name “Shatavari” means “a woman who possess 100 children”, referring to the shatavari rejuvenation effect in female reproductive organs.. Aromatic and medicinal plants have played significant role in the lives of humans by providing products for both food and medicine. Shatavari has been described to use as antioxidant, immune stimulant, and anti tussive effects. It is also very useful and effective in the treatment of cancer, kidney disorder, chronic fevers, ulcers, chronic fevers etc. Main use of this drug is in female disorders and several menstrual disorders. The present article explores the taxonomy, morphology, cultivation, harvesting and biological properties of A. racemosus.
Never Have I Ever: A Critical Analysis on the Role of Netflix in Promoting Multiculturalism
Authors: - Prerna Guha
Published: October 2023

Netflix, a pioneering streaming platform in the era of the rise of OTT platforms’ popularity, has established itself as an advocate of multiculturalism unlike any other contemporary in its time. It thrives by producing and featuring a diversity of content that includes stories, cast, and characters from various cultural backgrounds.

Through its method of narrating stories, Netflix represents the cultural inclusivity, appreciation, and mutual understanding of cultures in the United States of America, representing it as a salad bowl. This research essay critically examines the web series Never Have I Ever that on one hand, underscores the role of Netflix in promoting multiculturalism, and on the other hand, it highlights the United States of America as a multicultural society. By close examination of the cast, storytelling, and themes of the web series, this article identifies the United States of America as a salad bowl wherein every culture is allowed to retain its individualistic identity while being a part of the community instead of a melting pot wherein all the cultures get dissolved into the American culture. With the showcasing of a cast from various backgrounds who face complex issues such as identity crisis and cultural assimilation, Never Have I Ever efficiently challenges the stereotypes and elicits empathy from the audience along with building an all-embracing society with unique identities.
Epitome of Endurance :O-lan in Pearl Buck's The Good Earth
Authors: - Sreeja J
Published: October 2023

Pearl S. Buck’s fiction is unique in its representation of Asia and above all her portrayals of Asian women. Buck’s second novel The Good Earth is her magnum opus. It is an enthralling family saga which also provides a genuine picture of agricultural life in China. It deals with the chief protagonist Wang Lung’s toils against hardships in nature and the support he gets from his wife O-lan in dealing with these troubles and his rise to the position of a property owner. The novel delineates his moral degradation after he gains a good economic status and the subsequent heartbreak that Wang Lung causes to O-lan, the woman who offered him unstinted support during his trying times. This paper is an attempt to delineate the courage and endurance of O-lan, an ordinary Chinese woman in facing the trials and tribulations of life. O-lan attracts us more with her genuineness than with her beauty. She displays courage, endurance and exhibits tough physical prowess.
Gender Equality and Microfinance
Authors: - Mrs.Sangita Chouhan , - Dr.Ashish Mishra
Published: October 2023

Microfinance is a type of Banking Service that is Provides to unemployed or Low Income Individuals or group who would otherwise have no other means of gaining financial service. Microfinance as the modern tool to combat Poverty for Rural development. Microfinance and self help group are effective in Reducing Poverty. Empowering women and creating awareness which finally result is sustainable development of the nation. The main Aim of Microfinance is to empower women.

In 1990 the problems of women workers in unorganized sector’s fro bad to worse as most of the women who were engaged in various self employment activities have last their livelihood, Despite in Substantial contribution of women’s to both household and national Economy, their work is considered Just an Extension of household domain and remains non-monetized. In India’s Microfinance Scene is dominated by SHG as an Effective Mechanism for providing financial service to the unreached poor and also in strengthening their collective self help capacities leading to their empowerment. Rapid progress in SHG formation has now turned into an empowerment movement among women Across the country. Microfinance is necessary to overcome exploitation, create confidence for Economic Self Reliance of the Rural Poor Particularly among Rules women. Although no magic bullet. They are potentially a very significant contribution to gender equality and women’s empowerment. Through their contribution to women ability to earn an Income. These programs have potential to Initiate a series of virtuous spirals. Economic empowerment and social political empowerment.”
Does Financial Inclusion Affect Financial Stability In Low-income Countries?
Authors: - Mohammad Rony
Published: October 2023

Inclusive financial system, a breakthrough on the way of exploiting the potentiality and opportunities of an economy which is considered as a prerequisite for Sustainable Development Goals (SDGs) around the globe, especially in the low-income economies apart from their economic and financial development. This scenario raises a question, whether financial inclusion ensures or degrades financial stability in low-income economies. A number of studies have been performed on this issue and have suggested both positive and negative ways in which financial inclusion could affect financial stability. But most of those studies were based on abroad sample of countries, including many high-income economies. This paper contributes to the existing literature on this subject by estimating the effect of financial inclusion on financial stability, especially on low-income economies. After analyzing the causal relationship, this paper finds that ensuring financial inclusion by greater ‘usage’ and ‘access’ of financial system contributes positively to the financial stability in low-income economies by reducing the NPL ratio and increased gross interest margin, even though it might cost with lower return on assets, increased non-interest expenses to maintain the additional credit expansion, and permitting some under-standard loans leading to disturbances in financial markets which are nominal in comparison with the benefit of fueling the productive sectors of the low-income economies. These findings suggest that policy measures to increase financial inclusion by ensuring easy access and greater usage would facilitate the financial stability in low-income economies.
Role of Conformational Changes in DNA Recognition in Transcription Factors having Helix-Turn-Helix Motif
Authors: - Sakshi Yadu
Published: October 2023

DNA-binding proteins play a crucial role in various cellular processes, some of these have a unique structural arrangement, the helix-turn-helix motif, which enables them to bind to DNA molecules in a specific manner. Upon binding to DNA, conformational changes occur in both the protein structure and the DNA molecule, making it essential to quantify and characterise these changes. This work aims to quantify and characterise the conformational changes in the protein structures. This is achieved by calculating the root-mean-square deviation of the protein structure in the free state and DNA bound state. A database is curated which has a significant number of DNA-bound and unbound pairs available. For the unbound structure of the proteins, pre-processing is required to remove chains other than those found in its corresponding DNA-bound structure followed by superimposing it to the DNA-bound structures obtained from the Protein Data Bank (PDB) to calculate the RMSD. 

After quantifying the conformational changes using RMSD values, the proteins are categorised into six types based on their observed conformational changes. In this study, the primary objective is to conduct a comprehensive analysis of conformational changes in DNA-binding proteins and investigate their correlation with various protein properties. By exploring these correlations, the study aims to unravel potential patterns or dependencies between the extent of conformational changes and the diverse properties of DNA-binding proteins. Such insights can shed light on the functional implications of structural variations in DNA-protein interactions, providing valuable information about how protein dynamics contribute to DNA recognition and binding.

In addition, this work endeavours to broaden its scope by attempting to replicate DNA-bound complexes through the utilisation of freely available structures. By doing so, it aims to assess the reliability and accuracy of docking methods in predicting and reconstructing these complexes. The primary objective is to evaluate the feasibility and effectiveness of such techniques in the context of complex formation between DNA and protein molecules.
Analisis Sistem Pengambilan Keputusan dalam Pembelian Mobil Menggunakan Metode Analytical Hierarchy Process
Authors: Marizka Dewi Auditya , Sukmawati Wilda , Agustiningsih Irma , Yusuf Indra , Rusnaenah Andi
Published: October 2023

Seiring berkembangnya zaman permintaan akan kendaraan roda empat semakin meningkat, karena memang tidak bisa dipungkiri kendaraan roda empat sangat diperlukan sekali oleh masyarakat untuk menunjang keseharian kegiatannya seperti dalam hal bekerja, berlibur, dan lain sebagainya. Pastinya dalam hal memilih kendaraan roda empat harus disesuaikan dengan kebutuhan si individu tersebut, karena sebuah mobil dengan jenis atau spesifikasi yang berbeda akan memiliki fungsi yang berbeda juga. Ada berbagai macam kriteria dalam hal memilih mobil yang harus diperhatikan si individu yang berkaitan. Hal inilah yang melatarbelakangi kami untuk melakukan penelitian dengan menggunakan Sistem Pendukung Keputusan (SPK) dalam proses pemilihan kendaraan roda empat dengan mengimplementasikan metode Analytical Hierarchy Process (AHP) dilakukan dengan cara melakukan pembobotan dan menetapkan prioritas sehingga pada akhirnya didapat alternatif terbaik dalam memilih kendaraan roda empat.
Consumo de sustancias ilícitas en jóvenes y sus alteraciones en el sistema nervioso.
Authors: Pérez Rodriguez Karolayn Nicolle , Castro Jalca Alexander Darío , Pillasagua Mero Antonella Roxana , Ordóñez Loor José Omar
Published: October 2023

La adicción es causada por un desequilibrio en el funcionamiento neurobiológico tras el consumo regular de una sustancia psicoactiva, este desequilibrio lleva al deseo de volver a consumir la sustancia psicoactiva, para no sufrir los efectos desagradables tras el cese de su ingesta, se trata de volver a la normalidad, no de sentirse mejor, el uso de drogas ilícitas es un importante problema de salud pública a nivel mundial, ya que se estima que millones de personas en todo el mundo, el presente trabajo tiene como propósito describir la importancia y consecuencias en el sistema nervioso que deja el consumo de sustancias ilícitas en jóvenes, la metodología a utilizar es un diseño narrativo documental de tipo descriptivo, ya que con este tipo de métodos se recopilara información sobre las modificaciones o alteraciones en el sistema nervioso de los jóvenes tras el consumo de drogas. Los resultados analizados demostraron que, en los trastornos adictivos, este mecanismo fundamental de la vida se ve perturbado, a veces por la ingestión de alguna sustancia como alcohol, drogas, que aumenta la sensación de placer, a veces por una disfunción inicial del cerebro. Como conclusión a nivel mundial el consumo de sustancias ilegales como la marihuana, anfetaminas, éxtasis, LSD, cocaína, H, opiáceos, muestran una gran prevalencia en la población joven y adulta.
Antiglobulina directa y su relación con la ictericia neonatal en pacientes atendidos en el Hospital Dr. NapoleónDávilaCórdova de enero a junio de 2022
Authors: Ponce Ibarra Jesus Alberto , Mendoza Hidalgo Karina Lisseth , Campozano Pin Silvana Noelia
Published: October 2023

Antiglobulina directa (DAT), se determina para monitorear la evidencia de isoinmunización en bebés generando hemolisis leve, aumentando las bilirrubinas en lactantes. DAT en paciente con ictericia neonatal es fundamental para establecer diagnóstico, tratamiento y pronóstico. En este trabajo tiene como objetivo caracterizar los resultados de prueba de DAT y su relación con la ictericia neonatal incluyendo resultados de bilirrubinas, en pacientes atendidos en el Hospital Dr. Napoleón Dávila Córdova del Cantón Chone-Manabí durante el periodo enero-junio del 2022. Un estudio observacional, descriptivo, de carácter retrospectivo y de corte transversal de los datos de los 44 pacientes que se atendieron en el área de neonatología en el periodo de estudio, a través de la revisión de la base de datos del hospital. El género que más representación estadística tuvo en el estudio es el masculino con un 52,30% el femenino con 47,70% con ictericia neonatal. De los cuales un 45,45 de las ictericias neonatales presentaron DAT positivo. Más de la mitad de los pacientes presentaron ictericia neonatal por incompatibilidad ABO con una estadía mayor de 2 días en el área de neonatología. Un 58,82% de los neonatos normalizaron sus valores de bilirrubinas y DAT al egreso de la sala de neonatología.
Virus del papiloma humano y su asociación con el cáncer cervicouterino: una perspectiva mundial
Authors: Zambrano Cedeño Alan Argenis , Perero Cobeña Yaritza Shirley , Alcocer Díaz Sirley , Valencia Lucas Erika Yomaira
Published: October 2023

El virus del papiloma humano se encuentra estrechamente asociado con el cáncer cervicouterino, de los más de 100 virus del papiloma humano, 40 son contagiados sexualmente y pueden infectar piel, mucosa oral y genital, siendo los tipos virales más frecuentes en las lesiones premalignas y malignas el 16 y 18. El cáncer cervicouterino es una patología multifactorial. El objetivo fue determinar la asociación del virus del papiloma humano y el cáncer cervicouterino. La metodología aplicada fue revisión de tipo documental, descriptiva. Entre los resultados se evidencio que el continente Africano es el continente donde la asociación cáncer-infección es más marcada. El cáncer cervicouterino a causa del virus del papiloma humano tiene una distribución mundial, sin embargo, de acuerdo con la literatura revisada, ciertas regiones presentan mayor número de casos a diferencia de otras. Las diferentes metodologías utilizadas en el diagnostico varían de acuerdo a las distintas zonas del mundo, a pesar de ello se evidencia que los métodos utilizados en la detección del cáncer cervicouterino a causa del VPH no tienen mucha variación de un continente a otro. Se concluye que el virus del papiloma humano  se evidencio significativamente en gran parte de los casos de cáncer de cuello uterino, lo cual manifiesta una estrecha asociación entre ambos.
Síndrome inflamatorio multisistémico pediátrico y COVID 19
Authors: Verdugo Calle Lizbeth Fernanda , Tirado Zhingri Samantha Dayanna , Clavijo Rosales Dra. Claudia Gabriela
Published: October 2023

El COVID-19, es la más reciente enfermedad que afectó a todas las personas así provocó una pandemia, los problemas con esta enfermedad se están estudiando ya que deja secuelas por lo cual está ocasionando un nuevo Síndrome Inflamatorio Multisistémico que ataca a cualquier grupo etario, pero es más comprometedor en niños, es de suma importancia conocer a fondo esta nueva enfermedad para tratarla. Con respecto a la clínica se observa y analiza distintos signos y síntomas, lo más específico son la fiebre, problemas gastrointestinales agudos, afección en la parte visual y en las mucosas cutáneas. Los pacientes que poseen un cuadro serológico positivo en SARS-CoV-2, las pruebas complementarias que deben realizarse son hemograma, elevación de marcadores inflamatorios y alteración en pruebas de la coagulación. En diversos casos, los pacientes pediátricos pueden presentar hipertransaminasemia, nitrógenos en retención, la actividad macrofágica, conformando así este nuevo síndrome. Para un tratamiento en el área de pediatría se optó por fármacos ya sea corticoides, inmunoglobulina intravenosa y ácido acetil salicílico, hasta ahora se sigue implementando sin cambiarlos por otros, porque estos medicamentos resultan efectivos, siendo estos muy competitivos ante este síndrome. Los pacientes pediátricos con este síndrome, no puede derivar otras enfermedades, las que se descartan son aneurismas de origen coronario, el paciente pediátrico al no tratarse puede llegar a tener miocarditis, shock, es de relevancia que el paciente debería de tener una vigilancia en cuidados intensivos para así no comprometer la vida, ya que sus defensas se encuentran deficientes así que son muy susceptibles.
Carga mundial de las enfermedades tropicales olvidadas
Authors: Cajape González Angie Lissette , Cano Alvarado Ashley Madelaine , Mendoza Rodríguez Michael Cristopher
Published: October 2023

Las enfermedades tropicales desatendidas (ETD) son una enfermedad tropical relacionada con la pobreza, por un lado, no se les presta suficiente atención, aunque están muy extendidas y conducen a enfermedades graves y duraderas, por otro lado, afectan particularmente a la parte más pobre de la población en países que ya son pobres, estas personas por lo general no tienen acceso a una atención médica adecuada, el objetivo de esta investigación es analizar la carga mundial que generan las enfermedades tropicales olvidadas. La metodología se trata un estudio narrativo documental de tipo descriptivo. Los resultados de esta revisión muestran la gran prevalencia de este tipo de infecciones y de la carga que representa para el sistema de salud pública mundial, asi como la peligrosidad de estas, se menciona que a nivel mundial existen un total de 2300 millones de casos. En conclusión, millones de personas en todo el mundo se ven afectadas por al menos una enfermedad tropical olvidada y millones mueren cada año como resultado de estas, afectan a las poblaciones de países pobres o de ingresos medios
Manejo del Dolor en Pacientes Oncológicos
Authors: Muñoz Macías Adriana Lisbeth , Alarcón Zambrano Diego Alejandro , Vélez Párraga Melani Stefania , Clavijo Rosales Dra. Claudia Gabriela
Published: October 2023

El dolor en los pacientes oncológicos se puede presentar de diferentes maneras, para lo cual con el progreso de esta enfermedad se han implementado nuevos planes para el manejo de estos síntomas, en donde se incluyen cuidados paliativos, acoplamiento de equipos asistenciales, uso de opioides, entre otras. La finalidad de esta investigación es describir los aspectos de dolor en pacientes con cáncer, reconociendo el tipo del dolor mediante su fisiopatología y cómo aplicar las medidas tanto farmacológicas como no farmacológicas para cesar o disminuir el dolor y ayudar a que el paciente lleve un mejor ritmo de vida durante su tratamiento. La presente investigación se llevó a cabo mediante una extensa revisión bibliográfica de documentos relacionados con el dolor en pacientes oncológicos y sus respectivas medidas terapéuticas, esto mediante bases de datos científicas como Scielo, Redalyc, ScienceDirect, Scopus, entre otras en los últimos 5 años de actualidad. La primera línea para tratar el dolor oncológico es la farmacológica, usando como guía la Escala Analgésica de la Organización Mundial de la Salud (OMS), pero al ser muy general ha sufrido varias modificaciones a lo largo de los años, tomando en cuenta también que no contiene medidas no farmacológicas, ya no es la única referencia para tratar el dolor causado por esta patología. El manejo del dolor en pacientes con cáncer es todo un reto, tanto para el profesional como para el paciente, por lo que implica, según los especialistas, un conflicto ético y moral. La primera línea de tratamiento implica fármacos muy fuertes, en donde se tiene que tomar la decisión de regirse a las normas o aliviar la angustia del paciente, es por eso que, actualmente, la mejor manera de tratar el dolor oncológico sigue en discusión.
Effect of spiral vanes width on the separation performance of a hydrocyclone
Authors: Liu Peikun , Wang Xiaoguo , Jiang Lanyue , Zhang Yuekan , Yang Xinghua , Li Xiaoyu , Wang Hui
Published: October 2023

Aiming at the problem of “entrainment fine particles in underflow” of hydrocyclone in grinding and classification process, a hydrocyclone with spiral vanes (the SV hydrocyclone) was proposed. The CFD techniques were used to study the pressure field, velocity field, turbulence field, particle field and classification efficiency of hydrocyclones with spiral vanes of different widths. The results show that the pressure drop, axial velocity, tangential velocity, turbulence intensity of SV hydrocyclone are reduced in different degrees compared with conventional hydrocyclone, and the reduction becomes more obvious with the increase of vane width. In the case of a vane width of 0.04D, the underflow recovery rate of 5μm and 10μm fine particles was reduced by 16.2% and 15.7%. The selection of spiral vanes with small widths is beneficial to improve the separation accuracy of fine particles and reduce the cut particle size.
High Pressure-Driven Batch Distillation Optimal Control for Methylacetate-Methanol Separation
Authors: Stojkovic Marija
Published: October 2023

The pressure-swing distillation process with high-pressurized batch columns (HHP), with and or without a recycling stream, for separating methyl acetate-methanol is studied from the aspect of optimal control. The results show that even though not heat integrated, the HHP process benefits productivity. Based on the maximum recovery, the dynamic controllability without any kind of heat integration is researched. The optimal cyclic reflux ratio operating policy is extended to the separation of a third non-ideal minimum boiling azeotrope and close boiling mixture of industrial importance, and it shows significant reductions in energy expenditure since the derived discontinuous energy function tends to show cyclic "behavior" again. The proposed process, however, has the economic potential of both capital and energy by internal heat integration, ie. connecting the reboiler of the lower high-pressurized column to the condenser of the higher high-pressurized column. In the future, even more azeotropes, both minimum and/or maximum boilers, should be investigated in order to establish a "heuristic guidance" for HHP design and industrial usage.
Parents' perceptions of their children's outdoor activities before and during COVID-19 crisis
Authors: Kadury-Slezak Michaella , Tal Clodie , Faruchi Sapir , Levy Iris , Tal Pninat , Tish Sigal
Published: October 2023

This study is focused on Israeli parents' perceptions regarding the possible benefits and barriers to their children's outdoor activities as well as on their reports on the actual engagement of their children in these kinds of activities, before and during the COVID-19 crisis. We employed a mixed-method design, including a questionnaire and a semi-structured interview. The participants were 213 Israeli parents. Findings reveal that parents think that outdoor activities benefit children's physical-motor and social development and their health. They consider their long work hours and weather conditions as the main barriers to spending more time outdoors. Parents also reported going out significantly less with their children to playgrounds after the peak of the COVID-19 crisis, compared to their habits before the pandemic. The decrease in the time spent outdoors was attributed by the parents to their long work hours and to an increase in the time spent by their children in front of screens. In light of the findings, we suggest that parents need guidance in order to restore the habit of going out to close playgrounds on an almost daily basis and in order to appreciate the contribution of outdoor activities to children's connectedness and knowledge about nature.
Outdoor activities promoting mental and physical health and well-being in Sámi Early Childhood Education and Care institutions
Authors: Bjerklund Monica , Åmot Ingvild
Published: October 2023

This article explores the current situation of outdoor play for children in Sámi Early Childhood Education and Care institutions (ECECs) in Norway. The main objective is to discover how Sámi ECEC practices contribute to outdoor play and learning in early childhood education and community contexts by addressing the following research questions: How do Sámi ECEC staff emphasize outdoor activities and play in their daily practice, and how can these activities be regarded as a way of promoting mental and physical health and well-being? The sample comprises practitioners from seven Sámi ECEC institutions (ECECs) participating in focus-group and individual interviews. The main focus of the interviews was on Sámi ECECs as health-promoting arenas, and outdoor activities appeared to be important in this context. Stepwise-Deductive Induction was used as a qualitative research strategy in the analysis. The staff underline the importance of letting children attempt to be autonomous when it comes to physical and practical activities. They point to the importance of knowing the children and encouraging autonomous achievements. Traditionally, Sámi upbringing places emphasis on doing handicraft and daily work together with the children. The staff describe doing such daily outdoor activities as harvesting, handicraft, and food preparation together with the children as a way of maintaining Sámi culture. The main conclusion is that outdoor activities are important for promoting, experiencing, and contributing to Sámi pedagogy and children’s well-being in the Sámi ECECs.
Late-stage diversification strategy for the synthesis of peptide acids and amides using hydrazides
Authors: Tanaka Shoko , Kanno Mizuki , Tashiro Yosuke , Narumi Tetsuo , Mase Nobuyuki , Sato Kohei
Published: October 2023

Aim: Modification of the C-terminus of a peptide to improve its properties, particularly after constructing the peptide chain, has great promise in the development of peptide therapeutics. This study discusses the development of a late-stage diversification method for synthesizing peptide acids and amides from hydrazides which can serve as a common precursor. Methods: Peptide hydrazides were synthesized solely by using conventional solid-phase peptide synthesis (SPPS). Hydrazides were subjected to oxidation by potassium peroxymonosulfate (Oxone) to afford carboxylic acids. Azidation of hydrazides using sodium nitrite (NaNO2) under acidic conditions, followed by the addition of β-mercaptoethanol (BME), could also be used to generate carboxylic acids. For the preparation of peptide amides, azides that can be prepared from hydrazides were reacted with ammonium acetate (NH4OAc) or tris(2-carboxyethyl)phosphine (TCEP)∙hydrochloride (HCl) to develop the products through ammonolysis or a Staudinger reaction, which produces iminophosphorane from an azide and a phosphine. The antimicrobial activity of modelin-5 derivatives synthesized from the corresponding hydrazides was evaluated by the colony count of Escherichia coli (E. coli) after treatment with the peptides. Results: Oxone oxidation yielded the corresponding acids rapidly although oxidation-prone amino acids were incompatible. Azidation and subsequent treatment with BME afforded peptide acids an acceptable yield even in sequences containing amino acids that are prone to oxidation. Both methods for conversion of hydrazides to amides were found to afford the desired products in good yield and compatibility. The conditions that were developed were adapted to the synthesis of modelin-5 derivatives from the corresponding hydrazides, yielding late-stage production of the desired peptides. The amides of the resulting peptide showed more potent activity against E. coli than the acid form, and the most potent activity was observed from the hydrazide. Conclusions: The developed protocols allow hydrazides to be converted to acids or amides, enabling late-stage diversification of peptide C-terminal residues.
Self-replicating RNA viruses in vaccine development
Authors: Lundstrom Kenneth
Published: October 2023

Self-replicating RNA viruses such as alphaviruses, flaviviruses, paramyxoviruses, and rhabdoviruses have been engineered as expression vectors for vaccine development. The prominent feature of self-replicating RNA viruses is their RNA-dependent RNA polymerase activity, which generates massive self-amplification of RNA in the cytoplasm of infected host cells leading to extreme levels of transgene expression. Infectious diseases have been targeted by overexpression of surface proteins of pathogens as antigens for vaccine development. Moreover, overexpression of tumor-associated antigens and immunostimulatory genes has been the basis for cancer vaccines. Proof-of-concept of robust antigen-specific immune responses and protection against challenges with lethal doses of infectious agents have been demonstrated. Likewise, vaccine development against various cancers has elicited strong immune responses and resulted in tumor regression and eradication, cure, and prolonged survival in animal tumor models. Good safety and immune responses have been achieved in clinical trials. The ERVEBO® vaccine, based on the vesicular stomatitis virus, has been approved for immunization against the Ebola virus disease.
The Endless Possibilities of Modelling of Toxic Chemical Warfare Agents and Possible Impacts of Their Release in Water Sensitive Areas
Authors: Stasinopoulos Nikolaos , Chalaris Michail , Tezari Anastasia , Kravari Kalliopi
Published: October 2023

Nerve agents are chemical compounds that constitute chemical weapons with many effects on human health as well as the environment. In this work, an analysis of the properties of several nerve agents and their dispersion in aquatic ecosystems is proposed, by exploring the possibilities of state-of-the-art computational methods, such as molecular dynamic simulations, quantitative structure-activity relationship models such and other simple computational models for the simulation of a water ecosystem.
Propuesta pedagógico-curricular desde la perspectiva del “Cubo líquido en el currículo fractal”
Authors: Hervitz Shai Sergio , Rodríguez Gómez María del Pilar
Published: October 2023

This innovation-research project set out to design an innovative curricular pedagogical proposal aimed at the operationalization of the creativity training from the paradigm of complexity and transdiciplinarity, for the formation of the initial teacher training and teaching projects at the National Education University of Ecuador (UNAE); like answering the challenges that the superior education assumes related with the ethics transformation and the training of engaged citizens with a critical society construction, creative and supportive; and with the ability to learn to face the complex contemporary society. The project was developed in four (4) phases, guided by a qualitative methodology for the collection of information and for the design of the proposal by the fusion of two approaches proposed by the authors. Firstly, the voluntary group of collaborators is formed, then beliefs, expectations are identified and the training needs in creativity are diagnosed by applying an instrument with guidelines for self-reflection to representatives of different levels of the education community of UNAE, that make up the group of collaborators of the Project. Next, pedagogical-curricular guidelines oriented to the development of creativity in UNAE are identified through documentary analysis. Later pedagogical strategies are designed from the liquid cube methodology, applied and reflected in conversations, reflection and creativity workshops with the group of collaborators. Finally, as a result of the project, the proposal of a pedagogical-curricular model for training in creativity at the higher education level is designed, from the fractal curriculum model that includes methodological strategies at the macro, meso and micro curricular levels, such as contribution to Higher Education Institutions, oriented to the pedagogical-curricular transformation from innovation processes.
APGICO y ASOCREA: Una historia común
Authors: Cardoso de Sousa Fernando
Published: October 2023

Starting from the history of the link between ASOCREA and APGICO, this article describes the methodological evolution that occurred in the intervention in organizational innovation, which we have carried out in public, private and third sector organizations. Taking the Simplex method of creative problem solving as a reference, we reduced the number of steps and the duration of the sessions, until we were left with only four steps, developed in a four-hour session. Given the need to expand the constitution of teams, we ventured into methodologies with large groups, trying to achieve a fusion between Organizational Development and the Social Psychology of Creativity, which would allow us to work with groups of more than 50 participants, in sessions of duration less than six hours. Having stabilized in the method, we expanded the intervention model with the diagnosis and installation of matrix systems, simultaneously by structure and by project, thus ensuring not only continuous innovation, but also the inclusion of more elements in the process. Finally, we went from the intervention to the training of innovation agents, who could lead the entire cycle within the organization itself. We are currently working on project management methodologies developed in creative problem solving sessions, seeking to learn how to work in low commitment environments.
La creatividad como expresión de la subjetividad: alternativas para el trabajo con adolescentes
Authors: Nunes de Souza Mozzer Geisa
Published: October 2023

The present study is the result of an ongoing research carried out at the Centro de Ensino, Pesquisa e Extensão do Adolescente, at the Federal University of Goiás - Brazil, it aims to discuss the concept of creativity, in addition to analyzing how the expression and manifestation takes place. of creativity in adolescence. The work proposes to reflect on the process of development of adolescents, specifically in their creative behaviors. It seeks to analyze indicators of creativity, as well as the subjective elements that underlie the creative action of adolescents. It is also intended to analyze the contextual elements that interfere in the expression of the subjects’ creativity. Starting from the historical-cultural perspective of Vygotsky (1896-1934) and his interlocutors, Fernado González Rey (2003, 2004 and 2005) and the conception of creativity as a process of subjectivity, developed by Mitjáns Martínez (1997 and 2005). It is noticed that creativity is not expressed as an isolated personality trait, but rather as the result of subjective configurations that are formed from social and emotional aspects, considering the role of the other in this process as fundamental.