bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment toxic effects of exposure to 3-indoleacetic acid via hemato-biochemical, hormonal, and histopathological screening in rats
Authors: Ismail Hager Tarek H.
Published: July 2022

The current study purposed to investigate the 3-indoleacetic acid (IAA) possible adverse impacts on hematological parameters, hepatorenal function, cardiac, and skeletal muscles as well as testes of rats and histopathological alterations of respective organs and to determine the extent of reversing any adverse impacts occurred in animals after IAA withdrawal. Rats were exposed orally to 500 mg/kg BW by gastric intubation once daily for 14 days, after which one-half was sacrificed and the remaining half left for a further 14 days without IAA exposure. The exposure of rats to IAA produced anemia, leukopenia, neutrophilia, lymphopenia, and a significant increase in activities of serum transaminase, gamma-glutamyl transferase, creatine kinase-myocardial band, creatine kinase-muscle type, and levels of serum creatinine, sodium, chloride, and potassium. Furthermore, serum levels of testosterone, gonadotropins, and leptin significantly declined. The changes in most of measured parameters continued after IAA withdrawal. Histopathological alterations in different tissues supported these changes. In conclusion, subacute exposure to IAA at a high concentration could exert hematotoxicity and toxic effects on many soft organs and its withdrawal led to incomplete recovery of animals. Thus, IAA should be used cautiously as extensive use of it at high concentrations can cause harmful effects on the environment, animals and human beings.
Software multihoming to distal markets: Evidence of cannibalization and complementarity in the video game console industry
Authors: Wiegand Nico , Peers Yuri , Bleier Alexander
Published: July 2022

Steady software supply is a crucial driver of platform sales. While publishers benefit from releasing software across multiple platforms to tap a greater market, platform manufacturers often seek exclusive release to differentiate from competitors. Research has examined such software multihoming across competing platforms of the same technology generation (i.e., the proximal market); however, publishers increasingly multihome software to platforms in distal markets. In the video game console industry, these include previous-generation consoles, handhelds, or mobile devices. This study investigates multihoming to distal markets in the seventh and eighth game console generations. Whereas multihoming to previous-generation consoles cannibalizes focal console sales, multihoming to mobile devices exerts complementary effects. Software quality and console age moderate these relationships, with negative spillovers from multihoming to previous-generation consoles being rooted in lower-quality games and games released later in the console’s lifecycle. By contrast, multihoming to mobile devices is most beneficial early on.
Immune Checkpoint Inhibitor Rechallenge After Prior Immune Toxicity
Authors: Bylsma Sophia , Yun Karen , Patel Sandip , Dennis Michael J
Published: July 2022

Opinion statement

Immune checkpoint inhibitors (ICIs) have become an essential part of treatment for many cancer types. These monoclonal antibodies remove a critical negative regulatory signal that allows the immune system to recognize and destroy malignant cells that were previously undetectable. Unfortunately, their use has ushered in a whole new form of drug toxicity whereby the immune system attacks normal tissues in the body, referred to hereafter as immune-related adverse events (irAEs). irAEs are common and can result in treatment discontinuation, hospitalization, and death. When alternative modes of treatment are limited, or considered less efficacious, there may be a desire to resume treatment with ICIs after an irAE. Rechallenge with ICIs carries with it a heightened risk of subsequent toxicity, but with careful consideration and appropriate patient selection, this can be considered a reasonable approach.
Inclisiran: How Widely and When Should We Use It?
Authors: Pirillo Angela , Catapano Alberico Luigi
Published: July 2022

Purpose of Review

Plasma levels of LDL cholesterol (LDL-C) are causally associated with cardiovascular risk. Reducing LDL-C results in a decreased incidence of cardiovascular events, proportionally to the absolute reduction in LDL-C. The inhibition of proprotein convertase subtilisin kexin 9 (PCSK) is a highly effective and safe approach to reducing LDL-C levels. In this review, we discuss the available data on the efficacy and safety of inclisiran, a siRNA targeting PCSK9 and propose a clinical profile for the patients who can benefit the most from this approach.

Recent Findings

Inclisiran is a small interfering RNA targeting the mRNA of PCSK9 specifically in the liver, owing to the conjugation with triantennary N-acetylgalactosamine. Randomized clinical trials have shown that inclisiran provides robust and durable reductions of PCSK9 and LDL-C levels, with a dosing schedule of once every 6 months after the initial and 3-month doses. These effects are consistent in different categories of patients, including patients with atherosclerotic cardiovascular disease and/or risk equivalent or patients with heterozygous familial hypercholesterolaemia. Ultimately the administration schedule may improve patients’ compliance given also the favourable safety profile of the drug.

Completion of ongoing outcome clinical trials will provide information on both the expected clinical benefit and the safety of inclisiran administered for longer.
Autopsy and its role in Franco’s dictatorship: a case of the last Republican mayor of the town Calera y Chozas (Toledo, Spain)
Authors: Šarkić Nataša , Carazo Miriam Saqqa , Ugarte Lucia Muñoz , López Jesús Herrerín
Published: July 2022

In the town of Calera y Chozas (Spain), five mass graves containing the remains of 28 individuals were discovered during a 2012 excavation. The witnesses and historical evidence indicated that the body of the last Republican mayor of the town, Felipe Fernández Varela, who had died in September 1939, was located in the mass grave designated as no. 1. Within this particular grave, only two bodies were found. Anthropological analysis showed that the first individual was significantly younger than 50 years, being the mayor’s age at the time of death, while the age of the second individual was closer to 50. This second individual had a fractured skull, with a depression on the left parietal bone, and there were unmistakable signs of autopsy, which consisted of cut marks on the frontal bone and the sternal extremity of the right clavicle. Further historical research revealed documents concerning the autopsy performed on this individual. Although, according to the report, the cause of death was a stroke — the consequence of atherosclerosis and alcoholism — no reference was made to the forceful impact to the skull or intracranial bleeding. Considering the size of the fracture on the skull and the fact that there were no signs of bone healing, we believe that this impact, and not the stroke, was the direct cause of the death of the last Republican mayor. The mayor’s case is a clear example of the role forensic medicine performed at the beginning of Franco’s dictatorship. The task was not only to conceal the crime but also to tarnish the victim’s name.
An analysis of child suicide from three centers (2008–2017)
Authors: Olds Kelly L. , Tse Rexson , Stables Simon , Baker Andrew M. , Hird Kathryn , Langlois Neil E. I. , Byard Roger W.
Published: July 2022

Although the overall suicide rate worldwide has changed minimally over the past 100 years, different trends have been observed over time in the USA, Australia, and New Zealand (NZ). However, few studies have focused on suicides in children (< 18 years), making evaluation of possible trends difficult. The last 20 years has also seen an increase in childhood obesity, eating disorders, and body image issues for children in many developed nations; however, few studies have shown whether a significant proportion of child suicides have an abnormal BMI. The current study evaluates child suicides (from 2008 to 2017) in South Australia (Australia), compared with the jurisdictions of Auckland (NZ) and Hennepin County (USA). Demographic data (age, sex, ethnicity), body mass index (BMI), the number of cases of youth suicide, and the method of suicide from these three regions were collected and analyzed. Across the 10-year period, the jurisdiction of Auckland had a downward trend, while Hennepin County and South Australia had increasing numbers of cases. The most common method of child suicide in all centers was hanging, occurring in > 80% of cases in South Australia and Auckland and 56% in Hennepin County. Hennepin County had a greater proportion of suicides using firearms (28%), compared to 1.9% in Auckland and 5.1% in South Australia. Unusual means of suicide were used less frequently by youth than previously.
„Die Last der großen Hoffnungen“ gemeinsam schultern
Authors: Haase Katrin , König Frank
Published: July 2022

In den Programmen der Bundesregierung gegen Rechtsextremismus und zur Stärkung der Demokratie werden u. a. Beratungsangebote für Betroffene rechter, rassistischer und antisemitischer Gewalt gefördert. Die Frage zu beantworten, was solche Angebote im „Kampf gegen Rechts“ bewirken können (oder auch nicht), ist Aufgabe ihrer wissenschaftlichen Begleitung und Evaluation. Der Beitrag führt kurz in Geschichte und Auftrag der Betroffenenberatung als Angebot in der Sozialen Arbeit ein und stellt anhand sozialräumlicher Interventionen der Berater_innen einen Ausschnitt ihrer wirkungsorientierten Evaluation vor.
Families in quarantine for COVID-19 in Italy. Resilience as a buffer of parental distress and problematic children’s emotions and behaviors
Authors: Pugliese E. , Mosca O. , Paolini D. , Mancini F. , Puntonieri D. , Maricchiolo F.
Published: July 2022

The pandemic of Covid-19 has had a high impact on people’s lives and especially on families. In Italy, in 2020, the several forced closures led families to live indoors to manage anxiety and distress. It was considered appropriate to investigate which protective factors, like parental resilience, can mitigate the negative impact of pandemic-related distress on family life. We have conducted two online surveys during different national lockdowns for Covid-19. The first survey was conducted immediately after the disruption of the virus and the second one after nine months. We measured parental resilience and distress, anxiety, problematic behaviors, and somatization of their children (as assessed by the parents). The aim was to investigate the protective role of parental resilience in mitigating parental distress and in turn problematic emotional states and behavior of their children. Mediation analyses confirmed the hypothesis that parental resilience lowers parental distress and consequently the anxiety and behavioral disorders of their children in both acute distress (first study) and chronic distress (second study) situations. Such results suggest that the improvement of parents’ resilience can buffer the negative impact of pandemic-related parental distress and children’s behavioral problems on both occasions. The need for focused interventions and treatments aimed to reinforce parental resilience is discussed. Targeted prevention and support strategies are needed now, and early in case of future health crises.
Too Much Freshwater, Not Enough, or Just Right? Long-Term Trawl Monitoring Demonstrates the Impact of Canals that Altered Freshwater Flow to Three Bays in SW Florida
Authors: Kendall Matthew S. , Williams Bethany L. , O’Donnell Patrick M. , Jessen Brita , Drevenkar Julie
Published: July 2022

Understanding the impact of anthropogenically altering freshwater flow to estuaries is a growing information need for coastal managers. Due to differences in watershed development, drainage canals, and water control structures, the Ten Thousand Islands area of southwest Florida provides an ecosystem-scale opportunity to investigate the influence of both more, and less, freshwater flow to coastal bays compared to locations with more natural hydrology. Bottom trawl and water quality data spanning 20 years were used to investigate how environmental and hydrological differences among three bays affect community structure of small estuarine fishes. Relationships between fish community structure and salinity and temperature variables were evaluated over timescales from 1 day to 3 months prior to each trawl. Longer-term aspects of temperature (i.e., 2–3 months) exhibited the highest correlations in all bays, suggesting that spawning cycles are the main cause of seasonal changes in fish communities, rather than differences in freshwater flow. Despite major contrasts in watershed manipulation and the seasonal salinity of one bay being much less than the others, the bays differed primarily based on relative abundances of more common species rather than due to unique suites of species being present. Truly freshwater conditions were never detected, and high salinity conditions were experienced in all bays during dry seasons. This likely prevents a community shift to freshwater species. The range in flow characteristics among bays and general similarity in fish communities suggest that conditions will remain within the tolerance of most fishes in all three bays following restoration to more saline conditions.
Validation of material models for sheet metals using new test equipment
Authors: Eder Matthias , Gruber Maximilian , Volk Wolfram
Published: July 2022

Validation is an important step after a calibration of models in order to assess their quality. In this work, new test equipment is presented that provides a comprehensive database for validation of material models for numerical analyses using FE simulation in sheet metal forming: the MUC-Test (acronym for Material Under Control). The introduced validation strategy is based on a comparison of experimental results with a numerical representation of the MUC-Test in terms of punch force and major and minor strain. The data comparison approach uses a full-field comparison over a wide range of punch stroke and thus considers the hardening behavior of the models. Extensive parameter studies are performed to investigate numerical, process and material model parameters regarding their influence on the test results. The presented validation method is applied to three materials of different material classes: The microalloyed steel HC340LA, the dual-phase steel DP590HD and the aluminum alloy AA5754. Furthermore, different material models based on the same database are compared for the DP590HD, showing the potential to identify suitable material models for specific requirements. Finally, equivalent material models based on different calibration strategies are compared. In conclusion, it is shown that the MUC-Test can be used to evaluate and compare different material models in terms of their ability to represent real material behavior in an effective and efficient way.
A forecasting model for the porosity variation during the carbonation process
Authors: Bretti Gabriella , Ceseri Maurizio , Natalini Roberto , Ciacchella Maria Carla , Santarelli Maria Laura , Tiracorrendo Giulia
Published: July 2022

In this paper we introduce a mathematical model of concrete carbonation Portland cement specimens. The main novelty of this work is to describe the intermediate chemical reactions, occurring in the carbonation process of concrete, involving the interplay of carbon dioxide with the water present into the pores. Indeed, the model here proposed, besides describing transport and diffusion processes inside the porous medium, takes into account both fast and slow phenomena as intermediate reactions of the carbonation process. As a model validation, by using the mathematical based simulation algorithm we are able to describe the effects of the interaction between concrete and CO$$_2$$

2

on the porosity of material as shown by the numerical results in substantial accordance with experimental results of accelerated carbonation taken from literature. We also considered a further reaction: the dissolution of calcium carbonate under an acid environment. As a result, a trend inversion in the evolution of porosity can be observed for long exposure times. Such an increase in porosity results in the accessibility of solutions and pollutants within the concrete leading to an higher permeability and diffusivity thus significantly affecting its durability.
Voices in practice: challenges to implementing differentiated instruction by teachers and school leaders in an Australian mainstream secondary school
Authors: Gibbs Kathryn
Published: July 2022

This paper investigates the challenges experienced by some Australian school educators in implementing differentiated instruction (DI) at a large secondary school. A small-scale study was conducted using individual, semi-structured interviews with teachers and school leaders. Using thematic analysis, three major themes were identified, namely: teachers’ barriers to implementing DI, school leaders’ constraints to implementing DI, and pre-service to in-service exchanges and sharing about DI. Findings from teachers revealed limited school resources, student behaviour issues and inadequate time for planning and implementation. School leaders also identified time as an impeding factor but also reticence by experienced teachers to use DI. Teacher education courses are not clear about DI as a comprehensive teaching framework suitable for all students. Results highlight the need for further research at the teacher educator, teacher and school leader level to remove existing barriers, constraints, and misunderstandings about DI to ensure maximum learning opportunities for all students.
High Conduction Band Inorganic Layers for Distinct Enhancement of Electrical Energy Storage in Polymer Nanocomposites
Authors: Zhu Yingke , Shen Zhonghui , Li Yong , Chai Bin , Chen Jie , Jiang Pingkai , Huang Xingyi
Published: July 2022

Dielectric polymer nanocomposites are considered as one of the most promising candidates for high-power-density electrical energy storage applications. Inorganic nanofillers with high insulation property are frequently introduced into fluoropolymer to improve its breakdown strength and energy storage capability. Normally, inorganic nanofillers are thought to introducing traps into polymer matrix to suppress leakage current. However, how these nanofillers effect the leakage current is still unclear. Meanwhile, high dopant (> 5 vol%) is prerequisite for distinctly improved energy storage performance, which severely deteriorates the processing and mechanical property of polymer nanocomposites, hence brings high technical complication and cost. Herein, boron nitride nanosheet (BNNS) layers are utilized for substantially improving the electrical energy storage capability of polyvinylidene fluoride (PVDF) nanocomposite. Results reveal that the high conduction band minimum of BNNS produces energy barrier at the interface of adjacent layers, preventing the electron in PVDF from passing through inorganic layers, leading to suppressed leakage current and superior breakdown strength. Accompanied by improved Young’s modulus (from 1.2 GPa of PVDF to 1.6 GPa of nanocomposite), significantly boosted discharged energy density (14.3 J cm−3) and charge–discharge efficiency (75%) are realized in multilayered nanocomposites, which are 340 and 300% of PVDF (4.2 J cm−3, 25%). More importantly, thus remarkably boosted energy storage performance is accomplished by marginal BNNS. This work offers a new paradigm for developing dielectric nanocomposites with advanced energy storage performance.
Data-driven versus a domain-led approach to k-means clustering on an open heart failure dataset
Authors: Jasinska-Piadlo A. , Bond R. , Biglarbeigi P. , Brisk R. , Campbell P. , Browne F. , McEneaneny D.
Published: July 2022

Domain-driven data mining of health care data poses unique challenges. The aim of this paper is to explore the advantages and the challenges of a ‘domain-led approach’ versus a data-driven approach to a k-means clustering experiment. For the purpose of this experiment, clinical experts in heart failure selected variables to be used during the k-means clustering, whilst during the ‘data-driven approach’ feature selection was performed by applying principal component analysis to the multidimensional dataset. Six out of seven features selected by physicians were amongst 26 features that contributed most to the significant principal components within the k-means algorithm. The data-driven approach showed advantage over the domain-led approach for feature selection by removing the risk of bias that can be introduced by domain experts. Whilst the ‘domain-led approach’ may potentially prohibit knowledge discovery that can be hidden behind variables not routinely taken into consideration as clinically important features, the domain knowledge played an important role at the interpretation stage of the clustering experiment providing insight into the context and preventing far fetched conclusions. The “data-driven approach” was accurate in identifying clusters with distinct features at the physiological level. To promote the domain-led data mining approach, as a result of this experiment we developed a practical checklist guiding how to enable the integration of the domain knowledge into the data mining project.
Identify multiple seeds for influence maximization by statistical physics approach and multi-hop coverage
Authors: Liao Fuxuan , Hayashi Yukio
Published: July 2022

Finding the influential vertexes as seeds in a real network is an important problem which relates to wide applications. However, some conventional heuristic methods do not consider the overlap phenomenon. In order to avoid the overlap of spreading, we propose a new method in combing the statistical physics approach and multi-hop coverage. We also propose a faster epidemic model which does not need the averaging of stochastic behavior. Through the computer simulation, the obtained results show that our method can outperforms other conventional methods in the meaning of stronger spreading power per seed.
Use of Functional Ink in a Smart Tag for Fast-Moving Consumer Goods Industry
Authors: Isohanni Jari
Published: July 2022

In the fast-moving consumer goods (FMCG) industry, current labelling solutions have challenges to meet the track & trace requirements. Currently, FMCG items use mainly paper-based self-adhesive labels with traditional barcodes. These labels are low priced and technically easy to produce and deploy. The shift towards advanced solutions, like radio frequency identification (RFID) or near field communication (NFC) tags, still does not offer a good enough cost/benefit ratio. These advanced solutions have a high unit price or require costly changes in production lines. Still, the industry recognizes the possibilities of smart tags. Recent research has shown that functional inks can operate as cheap sensors. However, more research is needed to take functional inks into the operational FMCG environment. This paper presents one technical solution for an FMCG smart tag. The proposed smart tag builds on traditional QR-Code and Datamatrix markers, printed with standard inks. However, it also has functional ink embedded inside the marker as a sensor. This research experiments how embedding impacts the overall performance of the smart tag decoding. And if the CIEDE2000 color difference algorithm can calculate the state of the sensor. Three different parameter combinations, CIEDE2000(1, 1, 1), CIEDE2000(2, 1, 1), CIEDE2000(2.76, 1.58, 1), and their accuracy are compared. Experiments show that the proposed approach does not negatively affect the decoding performance. And that a color comparison can detect sensor states, especially when the functional ink has high enough color intensity. Between different parameters, CIEDE2000(2.76, 1.58, 1) performed best, especially in the low-intensity test. However, some future research needs to address absolute color value detection and the accuracy of color recognition; especially when if the color has low intensity.
Mapping diversity: from ecology and human geography to urbanism and culture
Authors: Baciu Dan C. , Mi Duola , Birchall Callum , Della Pietra Diana , van Loevezijn Luca , Nazou Anna
Published: July 2022

A large body of research across science and humanities has come to deal with diversity, which, as a scientific concept, has proved immensely relevant in helping researchers understand anything from ecosystems and natural habitats to cities and culture. Here, we develop a first method to quantify and map urban diversity. Our article begins with a concrete example through which we demonstrate how to apply a basic version of our method to create a diversity map for a given urban area. This map is easy to interpret and can be used to accurately locate the most diverse centers of urban activity. We then go on to show how our basic method can be expanded to quantify many different types of urban diversity, and how it can be used to create regional and global diversity maps. Such diversity maps are relevant in both studying diversity and modeling the dynamics of diversification in urban environments. We conclude the article by making a bridge to other scientific disciplines, and by proposing six key steps that may serve as a foundation for a general framework for the evaluation and mapping of diversity across all fields of science.
Is AI recruiting (un)ethical? A human rights perspective on the use of AI for hiring
Authors: Hunkenschroer Anna Lena , Kriebitz Alexander
Published: July 2022

The use of artificial intelligence (AI) technologies in organizations’ recruiting and selection procedures has become commonplace in business practice; accordingly, research on AI recruiting has increased substantially in recent years. But, though various articles have highlighted the potential opportunities and ethical risks of AI recruiting, the topic has not been normatively assessed yet. We aim to fill this gap by providing an ethical analysis of AI recruiting from a human rights perspective. In doing so, we elaborate on human rights’ theoretical implications for corporate use of AI-driven hiring solutions. Therefore, we analyze whether AI hiring practices inherently conflict with the concepts of validity, autonomy, nondiscrimination, privacy, and transparency, which represent the main human rights relevant in this context. Concluding that these concepts are not at odds, we then use existing legal and ethical implications to determine organizations’ responsibility to enforce and realize human rights standards in the context of AI recruiting.
Lie Symmetry Analysis and Conservation Laws for the (2 + 1)-Dimensional Dispersionless B-Type Kadomtsev–Petviashvili Equation
Authors: Zhao Qiulan , Wang Huanjin , Li Xinyue , Li Chuanzhong
Published: July 2022

The Lie symmetry analysis is adopted to the (2 + 1)-dimensional dispersionless B-type Kadomtsev–Petviashvili (dBKP) equation. The combination of symmetry analysis and symbolic computing methods proves that Lie algebra of infinitesimal symmetry of the dBKP equation depends on four independent arbitrary functions and one arbitrary parameter. The Lie algebra is reduced to four classes for deriving commutative relations, group invariant solutions of dBKP equation and conservation laws, and the optimal system of 1-dimensional subalgebras from one class is constructed. Based on the optimal system and other particular infinitesimal symmetries, plentiful symmetry reductions and invariant solutions are computed by using Lie group method. Six successive symmetries and conserved quantities of the dBKP equation are linked by the new conservation theorem. Besides, exact solution of the dBKP equation is constructed according to a conservation vector.
Paraconsistency in Mathematics
Authors: Weber Zach
Published: July 2022

Paraconsistent logic makes it possible to study inconsistent theories in a coherent way. From its modern start in the mid-20th century, paraconsistency was intended for use in mathematics, providing a rigorous framework for describing abstract objects and structures where some contradictions are allowed, without collapse into incoherence. Over the past decades, this initiative has evolved into an area of non-classical mathematics known as inconsistent or paraconsistent mathematics. This Element provides a selective introductory survey of this research program, distinguishing between `moderate' and `radical' approaches. The emphasis is on philosophical issues and future challenges.
Public managers’ trust in citizens and their preferences for behavioral policy instruments: evidence from a mixed-methods study
Authors: Migchelbrink Koen , Raymaekers Pieter
Published: July 2022

Local public managers increasingly use behavioral policy instruments to influence the behavior of citizens. However, despite their increased reliance on these instruments, there is little evidence on why local public manager would prefer behavioral instruments over classic stick, carrot or sermon-type instruments. We conduct a mixed-methods study, combining a stated-preference survey and two focus groups, to examine whether senior local public managers (directors and deputy directors) in Flanders prefer behavioral policy instruments over classic stick, carrot and sermon-type instruments, and explore whether their trust in citizens (perceptions of citizen's ability, benevolence and integrity) affects these preferences for policy instruments. The results indicate that in some policy areas, such as health, public nuisance and road safety, public managers appear more willing to use behavioral policy instruments than classic sticks and carrots, but not sermons. Furthermore, we find that public managers’ trust in citizens does not appear to significantly affect their preferences for policy instruments, but that political and economic motives do play a role in their preferences for behavioral policy instruments. Finally, the results also indicate that the simultaneous use of behavioral and classic policy instruments (packaging) can help mediate the perceived risks of citizens’ non-compliance with behavioral policy instruments.
Smart Contracts, Consumer Protection, and Competing European Narratives of Private Law
Authors: Maugeri Marisaria
Published: July 2022

The author makes brief Considerations on the Treatment of the Theme of the Relationship Between New Technologies and Private Law. In particular, she believes that the criticism of Lessig’s statement according to which “the values of real-space sovereigns will at first lose out” is correct, adding, however, that one must monitor the evolution of new technologies. We are, in fact, at the crossroads of a technological revolution which, as jurists, we are not able to fully understand. The author also questions the position taken in the volume on the US neoliberal approach v. European solidarity approach, inviting the authors to question the difference between the narrative that sees the European system as all about ensuring solidarity and the reality about the economic thinking that informs the different disciplines. Finally, she takes a position on the relationship between ordoliberalism and consumer protection.
Changing Land Use and Political Economy at Neolithic and Bronze Age Knossos, Crete: Stable Carbon (δ13C) and Nitrogen (δ15N) Isotope Analysis of Charred Crop Grains and Faunal Bone Collagen
Authors: ISAAKIDOU VALASIA , HALSTEAD PAUL , STROUD ELIZABETH , SARPAKI ANAYA , HATZAKI ELENI , NITSCH ERIKA , BOGAARD AMY
Published: July 2022

Excavations at Knossos have uncovered faunal and archaeobotanical archives spanning the Neolithic and Bronze Age (7th–2nd millennia bce), during which one of Europe’s earliest known farming settlements developed into its first major urban settlement and centre of one of its oldest regional states. Through stable isotope (δ13C, δ15N) analysis of seeds and bones (as evidence for the growing conditions of cereal and pulse crops and for the types of forage consumed by livestock), land use and, ultimately, political economy are explored. Changing husbandry conditions overwrite any effects of long-term aridification. Early (7th–6th millennium bce) Knossian farmers grew intensively managed cereals and pulses (probably in rotation) that were closely integrated (as manured sources of forage) with livestock. Through the later Neolithic and Bronze Age, settlement growth accompanied more extensive cultivation (eventually with cereals and pulses not in rotation) and greater use of rough graze and, by goats, browse. Pasture on cultivated land remained central, however, to the maintenance of sheep, cattle, and pigs. Variable diet of early sheep suggests management at the household level, while thereafter progressive dietary divergence of sheep and goats implies their separate herding. Until the Old Palace phase (early 2nd millennium bce), urban growth was matched by increasingly extensive and probably distant cultivation and herding but somewhat more intensive conditions during the New and Final Palace phases (mid-2nd millennium bce) perhaps reflect greater reliance on surplus from prime land of previously rival centres that now came under Knossian control.
Adherence to a traditional Mexican diet and non-communicable disease-related outcomes: secondary data analysis of the cross-sectional Mexican National Health and Nutrition Survey
Authors: Valerino-Perea Selene , Armstrong Miranda E. G. , Papadaki Angeliki
Published: July 2022

This study evaluated the association between adherence to a traditional Mexican diet (TMexD) and obesity, diabetes and CVD-related outcomes in secondary data analysis of the cross-sectional Mexican National Health and Nutrition Survey 2018–2019. Data from 10 180 Mexican adults were included, collected via visits to randomly selected households by trained personnel. Adherence to the TMexD (characterised by mostly plant-based foods like maize, legumes and vegetables) was measured through an adapted version of a recently developed TMexD index, using FFQ data. Outcomes included obesity (anthropometric measurements), diabetes (biomarkers and diagnosis) and CVD (lipid biomarkers, blood pressure, hypertension diagnosis and CVD event diagnosis) variables. Percentage differences and OR for presenting non-communicable disease (NCD)-related outcomes (with 95 % CI) were measured using multiple linear and logistic regression, respectively, adjusted for relevant covariates. Sensitivity analyses were conducted according to sex, excluding people with an NCD diagnosis and using multiple imputation. In fully adjusted models, high, compared with low, TMexD adherence was associated with lower insulin (−9·8 %; 95 % CI (−16·0, −3·3)), LDL-cholesterol (−4·3 %; 95 % CI (−6·9, −1·5)), non-HDL-cholesterol (−3·9 %; 95 % CI (−6·1, −1·7)) and total cholesterol (−3·5 %; 95 % CI (−5·2, −1·8)) concentrations. Men and those with no NCD diagnosis had overall stronger associations. Effect sizes were smaller, and associations weakened in multiple imputation models. No other associations were observed. While results may have been limited due to the adaptation of a previously developed index, the results highlight the potential association between the TMexD and lower insulin and cholesterol concentrations in Mexican adults.
SOVEREIGNTY FICTIONS IN THE UNITED KINGDOM'S TRADE AGENDA
Authors: Gammage Clair , Syrpis Philip
Published: July 2022

This article explores how sovereignty fictions have been used to advance different legal, political and economic aims in the articulation of the United Kingdom's future approach to global regulation. By mapping the transformative shifts in sovereignty paradigms, this article highlights the disconnect between the absolutist sovereignty popularised in the UK government's political rhetoric and the concept of regulatory sovereignty that underpins the UK's future trading strategy. To maintain its status as a global leader in regulation and standards-setting, the UK government will need to diffuse power and delegate autonomy through networked orders of public and private actors. These competing sovereignty paradigms are analysed with reference to European Union (EU) law and practice, to highlight the opportunities and challenges for the UK as an independent trade actor. This article concludes by evaluating how sovereignty fictions can disrupt the objectives of the UK's proposed ‘common law’ approach to regulatory governance and discusses the policy interventions that may be required to enable the UK to harness its potential as a regulatory leader.
THE FINAL FRONTIER OF CYBERSPACE: THE SEABED BEYOND NATIONAL JURISDICTION AND THE PROTECTION OF SUBMARINE CABLES
Authors: Guilfoyle Douglas , Paige Tamsin Phillipa , McLaughlin Rob
Published: July 2022

Cyberspace is now acknowledged not only as the newest domain of warfare, but also as a space vital to economic, educational and cultural development for all States. This thin consensus ignores the fundamental fact that the backbone of cyber infrastructure—submarine telecommunication cables—is not (for the large part) located within sovereign territorial jurisdiction. The radically increased reliance of States upon submarine data cables emphasises their vulnerability to damage by malicious acts, accidents, or natural phenomena. Faced with these problems, legal analysis has tended to identify gaps or deficiencies in the law, and propose the creation of new legal instruments. The contribution of this article is twofold. First, it expands the frame of analysis to include deliberate damage to cables not only in peacetime but under the law of armed conflict. Second, rather than treating the legal framework as inherently deficient, it considers the extent to which existing rules and principles can be progressively developed, interpreted, or creatively applied to close perceived gaps. This article surveys the existing law specific to the protection of submarine cables and assesses how general principles of the law of the sea, State responsibility, the law on the use of force, and the law of armed conflict apply to this problem. It thus considers in turn the applicable ‘law of peace’, the jus ad bellum and the jus in bello.
THE TERRACOTTA ANIMAL FIGURINES FROM DESPOTIKO: THE LIFE OF HUMANS AND OBJECTS IN THE EARLY IRON AGE CYCLADES BEYOND POLARITIES
Authors: Alexandridou Alexandra
Published: July 2022

Mandra, on the uninhabited islet of Despotiko in the middle of the Aegean Sea, is well known to the archaeological community, owing to the discovery there in 2001 of an extensive sanctuary of Apollo. Twenty-two edifices have come to light so far, and the systematic excavation continues to elucidate the long history of the site. The Early Iron Age marked the earliest activity there, traces of which offer fertile grounds for reconsidering life in the Cyclades at the time. The richest evidence for this period is offered by a secondary deposition, detected near two Early Iron Age buildings, which revealed thousands of clay sherds, extending from the late ninth/early eighth to the late sixth century BC, quantities of animal bones, and more than 60 metal objects. This article focuses on a small group of Early Iron Age terracotta animal figurines from this deposition. Critically analysing both their association with ritual and the polarity of ritual and profane, an attempt is made to unravel the lifecycle of these figurines, treating them as agents of activity. Their function and meaning are interwoven with the activities operating at the site during the Early Iron Age, at least two centuries before the foundation of the Archaic temenos.
Somatic maintenance/reproduction tradeoffs and human evolution
Authors: Hawkes Kristen
Published: July 2022

The authors propose that many morbidities higher in women than men are adaptations protecting survival, selected because survival has been especially crucial to mothers' reproductive success. Following their lead, I pursue variation in tradeoffs between reproduction and survival recognized by Darwin that were likely central to the evolution of many traits that distinguish us from our great ape cousins.
Pathological complexity and the evolution of sex differences
Authors: Veit Walter , Browning Heather
Published: July 2022

Benenson et al. provide a compelling case for treating greater investment into self-protection among females as an adaptive strategy. Here, we wish to expand their proposed adaptive explanation by placing it squarely in modern state-based and behavioural life-history theory, drawing on Veit'spathological complexityframework. This allows us to make sense of alternative “lifestyle” strategies, rather than pathologizing them.
“Staying alive” in the context of intimate partner abuse
Authors: Humeny Courtney
Published: July 2022

Females are disproportionately affected by intimate partner abuse that can result in severe physical and mental harm. Benenson et al. provide little exploration of how female-evolved traits enhance females' survival in abusive relationships. Discussion centres on “why” females do not “just leave” an abusive relationship and the effectiveness of female-evolved traits in navigating intimate partner abuse over time.
Only as a last resort: Sociocultural differences between women and men explain women's heightened reaction to threat, not evolutionary principles
Authors: Huntsinger Jeffrey R. , Raoul Akila
Published: July 2022

The target article proposed that women display greater self-protectiveness than men to major physical and social threats because such self-protective responses have higher fitness value for women than men. Rather than having evolutionary roots, we suggest the various physiological, behavioral, and emotional responses to social and physical threats exhibited more by women than men are instead rooted in sociocultural forces.
Sex differences are insufficient evidence of ecological adaptations in human females
Authors: Aung Toe , Baek Sojung , Puts David
Published: July 2022

Benenson et al. postulate that human females evolved unique survival adaptations to facilitate maternal and grandmaternal care. This hypothesis is consistent with the broader hypothesis that female phenotypes are more ecologically optimal, but further evidence is needed to make a compelling case that sex differences in self-protection are not primarily the result of more intense sexual selection on males.
Beyond individual sex differences: “Staying alive theory” as an adaptive complex
Authors: Archer John
Published: July 2022

Extended staying alive theory (SAT) raises the issue of the extent to which its various attributes are linked or whether they provide alternative means to the same adaptive ends. Theories such as SAT that consider an array of sex differences may benefit from the application of the multivariateDstatistic, rather than using a series ofdvalues, as is common at present.
Females undergo selection too
Authors: Benenson Joyce F. , Webb Christine E. , Wrangham Richard W.
Published: July 2022

Extending Campbell's (1999) staying alive theory (SAT) beyond aggression, we reviewed evidence that females are more self-protective than males. Many commentators provided additional supporting data. Sex differences in life-history adaptations, in the optimal relation between survival and reproduction, and in the mechanisms underlying trade-offs involved with self-protection remain important topics with numerous opportunities for improved understanding.
Pubertal timing moderates the same-day coupling between family hassles and negative affect in girls and boys
Authors: Gajos Jamie M. , Russell Michael A. , Odgers Candice L. , Hoyle Rick H. , Copeland William E.
Published: July 2022

This study examined the association between pubertal timing, daily affect, conduct problems, and the exposure to hassles across family, peer, and school contexts. Adolescents (Mage= 12.27; 49.7% female; 62.6% White) completed ecological momentary assessments across 14 consecutive days (N= 388). Earlier maturing girls reported lower daily averages of positive affect compared to their same-sex, same-age peers. We did not find evidence for a relationship between pubertal timing and daily negative affect or conduct problems in girls, nor for daily negative and positive affect or conduct problems in boys. However, pubertal timing did moderate the day-level association between average negative affect and family hassles for both girls and boys. When experiencing more family hassles, earlier maturing girls reported greater negative affect relative to later maturing girls who experienced family hassles. In contrast, later maturing boys, relative to earlier maturing boys, reported higher levels of negative affect in the context of family hassles.
Genre effect on Google Translate–assisted L2 writing output quality
Authors: Alrajhi Assim S.
Published: July 2022

This study investigates and compares the quality of Google-translated texts (GTTs) across writing genres (narrative, descriptive, expository, and persuasive) with EFL student–generated texts (SGTs), and explores students’ attitudes toward Google Translate (GT) output. In a mixed-methods design with a computational approach to text analysis, this study utilizes multiple data sources, including 328 written texts, written reflections, four attitude questionnaires, focus group discussion, and individual interviews. Forty-one Arabic-speaking undergraduate students majoring in English language and translation at a Saudi university participated in this study. They engaged in eight computer-mediated writing sessions by responding to tasks using English, then responding to the same tasks using their first language (L1). Subsequently, they utilized GT to translate L1 texts into English and compared SGTs with GTTs. The findings show that GTTs have higher literacy levels and richer content in the persuasive and expository genres, and higher style levels in the narrative and descriptive genres. Moreover, the comparison between SGTs and GTTs reveals that GTTs have higher literacy levels, better style, and richer content in the descriptive, expository, and persuasive genres. Meanwhile, the students hold positive views on the general quality, grammatical accuracy, and provision of lexical alternatives in GTTs across genres. Pedagogical implications are discussed.