bluuebunny/crossref_metadata_2025 huggingface dataset:
The Value of Tumor Infiltrating Lymphocytes (TIL) for Prediction of Response to Neoadjuvant Chemotherapy (NAC) in Breast Cancer According to the Molecular Subtype
Authors: Faur Ionut Flaviu , Dobrescu Amadeus , Clim Adelina , Pasca Paul , Prodan-Barbulescu Catalin , Gherle Bogdan Daniel , Tarta Cristi , Isaic Alexandru , Brebu Dan , Duta Ciprian , Totolici Bogdan , Lazar Gabriel
Published: October 2023

Introduction: Antitumor host immune response is an important factor, but its role is not fully established. The role of tumor infiltrating lymphocytes (TIL) in breast cancer as an immunological biomarker has been significantly explored over the past years. The number of patients treated with neoadjuvant chemotherapy (NAC) increased and identification of a biomarker to predict the probability of pCR (pathological complete response) is a high priority. Materials and methods: We evaluated 334 cases of BC treated with NAC followed by surgical resection from 2020-2022 in Ist Clinic of Oncological Surgery, Oncological Institute "Prof Dr I Chiricuta" Cluj Napoca. Of the above, 122 cases were available for histological evaluation both in pre-NAC biopsy and post-NAC resection tissue. Evaluation of biopsy fragments and resection parts using hematoxylin eosin (H&E). The TIL evaluation took place according to the recommendations of the International TIL Working Group (ITILWG). Results: There was a strong association between elevated levels of pre-NAC TIL. At the same time, there is a statistically significant correlation between stromal TIL and tumor grade, the number of lymph node metastases, the molecular subtype, and the number of mitoses (p <0.005). Intratumoral TIL showed a significant correlation with tumor size, distant metastasis, molecular subtype, number of mitosis, stage and lymph node metastasis (p<0.005). We also demonstrated that high pre-NAC TILs represent a strong predictive marker for pCR. Conclusion: This study reveals the role of TIL as a predictive biomarker in breast cancer not only for the well-established TNBC (triple negative breast cancer) and HER2+ (Her2 overexpressed) subtypes but also in Luminal A and B molecular subtypes. In this scenario, the evaluation of TILs as novel predictive and therapy-predicting factors should become a routinely performed analysis that could guide clinicians into the choice of the most appropriate therapy.
Steroid-Induced Hyperglycemia and Its Effect on Outcomes of R-CHOP Chemotherapy for Non-Hodgkin Lymphoma
Authors: Kristjanson Mark , Lambert Pascal , Decker Kathleen , Bruin Sonja , Tingey Elizabeth , Skrabek Pamela
Published: October 2023

Large doses of steroids are integral to R-CHOP, a first-line systemic therapy for diffuse large B-cell lymphoma (DLBCL), an aggressive form of non-Hodgkin Lymphoma (NHL). Patients on R-CHOP often develop clinically significant hyperglycemia from steroids. There is evidence of harms from steroid-induced hyperglycemia in the context of chemotherapy which are associated with a reduction in overall survival [1, 2]. The objective of our study was to characterize the effect of steroid-induced hyperglycemia on outcomes of R-CHOP chemotherapy for DLBCL. Methods: We performed a retrospective chart review of 188 patients with DLBCL treated with R-CHOP through CancerCare Manitoba (CCMB) from January 01, 2010 to December 31, 2014. Patients diagnosed with DLBCL were identified through the Manitoba Cancer Registry. The CCMB electronic medical record was reviewed to examine association between steroid-induced hyperglycemia and subsequent infection, including febrile neutropenic events, and overall survival (OS). Results: Patients who developed hyperglycemia with steroid exposure became hyperglycemic during their first R-CHOP cycle. No significant differences in OS or rates of infection were found between the two groups. Conclusions: Patients destined to develop steroid-induced hyperglycemia declare themselves early in the course of steroid exposure. No statistically significant reduction in overall survival attributable to steroid-induced hyperglycemia was found.
Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract
Authors: Micucci Matteo Micucci , Bartoletti-Stella Anna , Abdullah Fuad Othman , Burattini Sabrina , Versari Ilaria , Canale Matteo , D'Agostino Federico , Roncarati Davide , Piatti Diletta , Sagratini Gianni , Caprioli Giovanni , Faenza Irene , Battistelli Michela , Salucci Sara
Published: October 2023

Abstract
Background: Gastric cancer, particularly adenocarcinoma, is a significant global health concern. Environmental risk factors, such as Helicobacter pylori infection and diet, play a role in its development.
Purpose: This study aimed to characterize the chemical composition and evaluate the in vitro antibacterial and antitumor activities of AOME. Additionally, morphological changes in gastric cancer cell lines were analyzed.
Study design: AOME was analyzed using HPLC-MS/MS and its antibacterial activity against H. pylori was assessed using the broth microdilution method. MIC and MBC values were determined, and positive and negative controls were included in the evaluation.
Methods: Anticancer effects were assessed through in vitro experiments using AGS, KATO-III, and SNU-1 cancer cell lines. The morphological changes were examined through SEM and TEM analyses.
Results: AOME contained several compounds, including caffeic acid, rutin, and hyperoside. The extract displayed significant antimicrobial effects against H. pylori, with consistent MIC and MBC values of 3.70 ± 0.09 mg/mL. AOME reduced cell viability in all gastric cancer cell in a dose and time-dependent manner.
Morphological analyses revealed significant ultrastructural changes in all tumor cells lines, suggesting the occurrence of cellular apoptosis.
Conclusions: This study demonstrated that AOME possesses antimicrobial activity against H. pylori and potent antineoplastic properties in gastric cancer cell lines. AOME holds promise as a natural resource for innovative nutraceutical approaches in gastric cancer management. Further research and in vivo studies are warranted to validate its potential clinical applications.
Plasmonic-Assisted Water Gas Shift Reaction of Gold Particles on TiO2
Authors: Idriss Hicham , Wahab Khaja , Mudiyanselage Kumudu
Published: October 2023

The effect of Localized Surface Plasmon (LSP) of 5 nm mean size Au particles deposited on TiO2 P25 was investigated during the photo-thermal water gas shift reaction (WGSR). The effects of CO concentration, excitation light flux and energy, and molecular oxygen addition during the reaction were investigated. The photocatalytic WGSR rate under light excitation with wavelengths extending from 320 to 1100 nm was found to be higher than the thermal reaction alone at the same temperature (85 oC). A ratio H2/CO2 of near unity was found at high concentrations of CO. Addition of molecular oxygen during the reaction resulted in a slight decrease of molecular hydrogen production while the rates of CO2 formation and that of CO consumption changed by one order of magnitude. More important, it was found that the WGSR rates were still high under only visible light excitation (600 - 700 nm). The results prove that Au LSP alone triggers this chemical reaction without the need to excite the semiconductor on which they are deposited.
Diffusion Idiopathic Skeletal Hyperostosis (DISH), a Link between Gut Microbiota and Spinal Degenerative Diseases
Authors: Ibrahim Iddrisu , Ayariga Joseph , Xu Junhuan , Boakai Robertson K. , Ajayi Olufemi
Published: October 2023

The interplay between Diffuse Idiopathic Skeletal Hyperostosis (DISH) and the gut microbiota represents a compelling area of research, offering insights into the relationship between spinal degenerative diseases and the gut's microbial inhabitants. This comprehensive review seeks to unravel the complex connection, shedding light on its implications for human health and potential therapeutic avenues. A crucial section dives into the world of gut microbiota (GM), exploring its impact on human health, featuring its defining characteristics, and highlighting its role in metabolism, immunomodulation, host interaction, and how its composition changes over time. The subsequent portion delves into the relationship between microbiome composition and pathological bone development, including the link between Intervertebral Disc Degeneration (IDD) and gut inflammation, emphasizing how gut inflammation and GM dysbiosis play pivotal roles. Further dissecting the interconnections, various axes of influence, including the gut-spine axis, gut-bone axis, gut-joint axis, gut-disc axis (specific to DISH), gut-ligament axis, and gut-muscle axis, are discussed. Of particular interest is the section on the impact of GM on DISH-derived pain, addressing a critical aspect of the condition's manifestation. The review discusses the potential of GM modulation as a treatment for DISH, providing hope for therapeutic advancements. Additionally, it highlights the positive impact of lifestyle interventions, such as dietary modifications, sleep optimization, and exercise regimens, in mitigating GM dysbiosis and potentially improving DISH outcomes. Lastly, the intriguing prospect of fecal microbiome transplant and its implications for DISH management is examined, opening new avenues for research and therapeutic interventions. In conclusion, this comprehensive review underscores the intricate interplay between DISH and the gut microbiota, offering a fresh perspective on the impact of GM on spinal degenerative diseases. It emphasizes the potential for innovative treatments, such as GM modulation and lifestyle interventions, and presents fecal microbiome transplant as an exciting area for future exploration.
Structural Characterization Composites Based on Butadiene Rubber and Expanded Perlite
Authors: Edres Nada , Buniyat-zadeh Irada , Turp Sinan Mehmet , Soylak Mustafa , Aliyeva Solmaz , Binnetova Nurlana , Guliyeva Naila , Mammadyarova Sevinj , Alosmanov Rasim
Published: October 2023

The article presents a method for obtaining new composites using a well-known mineral, expanded perlite (EP), and an industrial polymer, butadiene rubber (BR). For the design of composites, a joint oxidative chlorophosphorylation reaction of BR and EP (as well as BR and modified EP) was carried out, and the modifications obtained from this reaction were further hydrolyzed. The structure and morphology of the obtained samples were characterized in detail using Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, X-ray powder diffraction, as well as scanning electron microscopy, and energy-dispersive X-ray analysis. EP and BR were separately modified with a similar reaction and characterized for data interpretation.
A Retrospective Chart Review of Treatment Patterns and Overall Survival among a Cohort of Patients with Relapsed/Refractory Mycosis Fungoides in France, Germany, Italy, Spain and the United Kingdom
Authors: Chalid Assaf , Illidge Timothy , Waser Nathalie , He Mary , Li Tina , Zomas Athanasios , Bentennakhil Nawal , Little Meredith , Ortiz-Romero Pablo L. , Pimpinelli Nicola , Dalal Mehul , Bagot Martine
Published: October 2023

(1) Background: Most patients with mycosis fungoides (MF), a form of cutaneous T-cell lym-phoma (CTCL), develop relapsed/refractory (R/R) disease following front-line systemic therapy. This report describes treatment patterns and outcomes from the subpopulation with R/R MF. (2) Methods: This observational, retrospective, cohort study analysed patient records (1984–2016) from 27 clinical sites in Eurpe. Outcomes included treatments received, response to first-, second- and third-line treatment, overall survival (OS), and progression-free survival (PFS). (3) Results: Of 104 patients with MF, 100 received second-line and 61 received third-line therapy. Median (range) times from start of first-line therapy to first R/R MF and from first to second R/R MF were 11.2 (0.3–166.5) and 13.5 (0.0–174.6) months, respectively. Second-and third-line treatment options varied and comprised systemic therapies (85% and 79% of patients, respectively), radio-therapy (32% and 34%, respectively) and topical therapies (48% and 36%, respectively). Median (95% confidence interval [CI]) OS from the diagnosis of first R/R MF was 11.5 (6.5–not reached [NR]) years and was higher with non-chemotherapy (NR) versus chemotherapy (6.5 years); es-timated median PFS (95% CI) from the time of first R/R MF was 1.3 (1.0–2.1) years. (4) Conclu-sion: High rates of R/R disease were observed after second- and third-line treatments in this re-al-world cohort, with longer median OS in patients receiving non-chemotherapy versus chemo-therapy. Following the standard management of MF and using recently approved targeted therapies can help improve patient outcomes in advanced-stage MF.
Insight into the Calculation Process to Decide Business Customer Value on the Digital Transformation Market
Authors: Titu Aurel Mihail , Cozmiuc Diana
Published: October 2023

As a service business models have been ranked by management consultants the management innovation of 2020, and yet are scarcely theorized. Therein, value stipulations in customer contracts lead to the shift from product to service. However, there is no available research about the nature, formula and decisional process about these value stipulations. The motive for this research is to fill in this gap. The goal is to provide first insight about value stipulations in as a service business models: their formula and decisional methodology. The article is a multiple theory building case study on leading platform as a service providers, which aims to contruct the paradigm of the value decision methodology to invest in this technology by purchasing it from dedicated vendors. The methodology works to identify the management instruments involved in the decisional activities to invest in digital technology, where each management instrument is assumed to match an activity at seller and buyer; the sequence of the activities using the Critical Path Method gives the decisional process. Dependent variables are the elements of the as a service business contracts: the customer offering (product-service solution) and the value created, captured and delivered by the solution. Independent variables are given by empirical data analysis. Findings show a relationship between dependent variable value in the as a service business model contracts and independent variables governance objective, strategy, as a service business model type, activity management techniques (roadmap, program, project, operations, lean start-up), capital allocation techniques (equity, debt, options, venture capital typology). If innovation is exploitative, then the customer offering is known and value is determinable via roadmap – project management techniques (program, project, an operations) and capital allocation techniques for precictable environment, If innovation is radical, then the customer offering is not known and value is a target used to architect the solution via lean start-up innovation techniques funded by venture capital. The contribution is a new theoretical construct and deep insight into the practice of digital transformation considering all inherent issues.
Effects of Antimicrobial Photodynamic Therapy Used to Sterilize Carious Dentin on Rat Dental Pulp Tissue
Authors: Takahashi Tenyu , Sato Fumiaki , Shinkai Koichi
Published: October 2023

Antimicrobial photodynamic therapy (aPDT) used to sterilize carious dentin may irritate the pulp tissues because of tissue-penetrating laser and singlet oxygen generation. This study aimed to assess the effects of aPDT on rat pulp tissues. A cavity formed in a rat maxillary first molar was treated with aPDT. The combined photosensitizer and laser irradiation conditions in the aPDT groups were as follows: methylene blue and 100 mW for 60 s, brilliant blue (BB) and 100 mW for 60 s, BB and 50 mW for 120 s, and BB and 200 mW for 30 s. Each cavity was treated with an all-in-one adhesive and filled with flowable resin. aPDT was not applied for the control. In each group, the rats were sacrificed on postoperative days 1 and 14, and thin sections of the treated teeth were prepared. Pulp tissue disorganization (PTD), inflammatory cell infiltration (ICI), and tertiary dentin formation (TDF) were evaluated. At 1 day evaluation, there were significant differences between the aPDT group and controls with respect to PTD and ICI. 14 days later, almost all specimens showed tertiary dentin formation. aPDT caused temporarily reversible injury to the rat dental pulp, which healed with tertiary dentin formation.
The Genomic Fabrics of the Excretory System’s Functional Pathways Are Remodeled in Clear Cell Renal Cell Carcinoma
Authors: Iacobas Dumitru ANDREI , Obiomon Ehiguese Alade , IACOBAS Sanda
Published: October 2023

Clear cell renal cell carcinoma (ccRCC) is the most frequent form of kidney cancer. Metastatic stages of ccRCC reduce the five-year survival rate to 15%. In this report we analyze the ccRCC-induced remodeling of the five KEGG-constructed excretory functional pathways in a surgically removed right kidney and its metastasis in the chest wall from the perspective of the Genomic Fabric Paradigm (GFP). GFP characterizes every single gene in each region by the independent variables: average expression level (AVE), relative expression variability (REV) and expression correlation (COR) with each other gene. While traditional approach is limited to only AVE analysis, the novel REV analysis indicates genes whose correct expression level is critical for cell survival and proliferation. COR analysis determines the real gene networks responsible for functional pathways. The analyses covered the pathways: aldosterone-regulated sodium reabsorption, collecting duct acid secretion, endocrine and other factor-regulated sodium reabsorption, proximal tubule bicarbonate reclamation, and vasopressin-regulated water reabsorption. The present study confirms the conclusion of our previously published articles on prostate and kidney cancers that even equally graded cancer nodules from the same tumor have different transcriptomic topologies. Therefore, the personalization of the anti-cancer therapy should go beyond the individual to his/her major cancer nodules.
Novel Genetic Systemic Obstructive Microvascular Dysplasia
Authors: Frustaci Andrea , Verardo Romina , Cianci Rosario , Cerbelli Bruna , D'Asdia Maria Cecilia , De Luca Alessandro
Published: October 2023

Here in it is described a new genetic microvascular obstructive disease causing progressive hypo-perfusion of human brain, heart and kidney.
Since the age of 30 years a male patient developed recurrent angina with normal coronary epicardial vessels but remarkable slow flow at angiography causing cardiac micro-aneurysms that at endomyocardial biopsy were associated to obstructive microvascular dysplasia. His history was followed in the seven decade by micro-hematuria characterized at kidney biopsy by renal microvascular dysplasia and frequent cerebral ischemic attacks with preserved structure of main brain arteries. Analysis of 5,600 genetic disease-causing genes revealed mutation of ABCC6, MMP2 and XYLT1 genes.
IMPACT OF THE COVID-19 PANDEMIC ON THYROID SURGERY: A RETROSPECTIVE STUDY
Authors:   Crimean Federal University, ZIMA DMITRY V. , ZYABLITSKAYA EVGENIA YU. ,   Crimean Federal University, GOLUBINSKAYA ELENA P. ,   Crimean Federal University, MAKSIMOVA РOLINA E. ,   Crimean Federal University, BEZRUKOV OLEG F. ,   Crimean Federal University, KUBYSHKIN ANATOLY V. ,   Crimean Federal University, NEPRITIMOVA ELENA A. ,   Crimean Federal University, KRIVENTSOV MAXIM A. ,   Crimean Federal University, GOLOVKIN ILYA O. ,   Crimean Federal University
Published: October 2023

Introduction. The COVID-19 pandemic has affected the pathomorphism of many diseases due to the pathophysiological impact of the infectious process and its drug therapy, and sometimes due to changes in the organization of medical care. During the pandemic, the number of patients with thyroid nodules has increased. Aim. To analyze the impact of the COVID-19 pandemic in Crimea on the surgical aspects of thyroid diseases. Material and methods. A study was made of the impact of the COVID-19 pandemic in Crimea on the surgical aspects of thyroid diseases. Statistical work was carried out with the data of the conclusions of cytological and pathomorphological diagnostics in 1244 patients during the period before, during and after the pandemic. A detailed analysis of cytology according to Bethesda was performed with the calculation of the percentage of conclusions of classes I-VI, morphological data of histological studies with a detailed assessment of malignant neoplasms. Results and discussion. After the start of the epidemic, at the preoperative stage of diagnosing thyroid nodules, an increase in the percentage of nodes with signs of cancer was noted compared to the period of 2019. During the pandemic, a reversible increase in the number of operations for toxic goiter and an irreversible increase in the proportion of malignant tumors were established; an increase in the incidence of B-cell adenomas; the prevalence after the pandemic of more differentiated forms of cancer with a low-risk prognosis, as well as tumors at earlier stages. Such dynamics is probably associated with a complex of factors: antigenic mimicry of the virus, its tropism for thyrocytes, stress and immunosuppression, paradoxically more timely seeking surgical care. Conclusion. The pandemic is characterized by an increase in the number of patients with primary manifestations of thyroid diseases, an increase in the number of toxic goiters and adenomas against the background of gland hyperfunction, a change in the incidence of papillary cancer - an increase in the number of patients, but the identification of prognostically more favorable forms.
MULTIMODAL DIAGNOSIS IN PATIENTS WITH METABOLIC SYNDROME COMPONENTS WHO HAVE SUFFERED INTERSTITIAL PNEUMONIA ASSOCIATED WITH COVID-19
Authors:   Crimean Federal University, KRADINOVA ELENA A. , CHERNOROTOV VLADIMIR A. ,   Crimean Federal University, KRADINOV ALEXEI I. ,   Crimean Federal University, KUBYSHKIN VLADIMIR A. ,   Crimean Federal University, KOSTENICH VIKTOR S. ,   Crimean Federal University, PALICH ANASTASIA R. ,   Crimean Federal University
Published: October 2023

Introduction. Coronavirus infectious disease caused by SARS-CoV-2 characterized by vast clinical variability. Extrapulmonary complications associated with endothelial damage, thrombosis and impaired regulation of immune responses provide unfavorable impact on the outcome of the disease and rehabilitation opportunities. Also, infection inflict damage to the gastrointestinal tract, hepatobiliary system. A key - roles to avoid aforementioned conditions are proper diagnosis and treatment plan, which should be make as soon as possible among the patients with elements of metabolic syndrome. The aim of the study - analyze the possibilities of multimodal diagnostics in patients with elements of the metabolic syndrome who get infected by SARS-CoV-2. Material and methods. In 41 patients with positive SARS-CoV-2, according to a nasopharyngeal smear study, the elements of the metabolic syndrome such as an increase in body mass index, serum triglycerides, and blood pressure were determined. Dynamic ultrasound of the abdominal cavity organs, CT scan of the chest in the near and distant periods were performed. Results and discussion. In the period 2020 - 2021. in patients with elements of the metabolic syndrome who have suffered of interstitial pneumonia caused by COVID-19, the predominant patterns was diffuse mosaic changes in lung tissue lesions with the spread of changes in lung parenchyma to more than one segment were identified. In a comparative aspect, dynamic multimodal diagnostics of abdominal organs was performed, confirming extrapulmonary complications from the liver: hepatosplenomegaly (p ≤ 0.01), changes of hemodynamics in hepatic vessels in patients with MS (p ≤ 0.05), increased stiffness and formation of liver parenchyma fibrosis in almost 15% (F2- F3). Conclusion. Study confirm the need for careful and long-term monitoring of patients, who are a in group of risk to develop metabolic syndrome with multimodal noninvasive ultrasound control of the condition of target organs.
COMPARATIVE ANALYSIS OF CLINICAL-ANAMNESTIC AND LABORATORY- INSTRUMENTAL CHARACTERISTICS OF PATIENTS WITH CORONARY ARTERY DISEASE LIVING IN THE FAR NORTH AND IN THE TEMPERATE CLIMATIC ZONE
Authors:   Tomsk National Research Medical Center of the Russian Academy of Sciences, MUSIKHINA NATALIA A. , PETELINA TATYANA I. ,   Tomsk National Research Medical Center of the Russian Academy of Sciences, GORBATENKO ELENA A. ,   Tomsk National Research Medical Center of the Russian Academy of Sciences, LARIONOVA OLGA N. ,   Tomsk National Research Medical Center of the Russian Academy of Sciences
Published: October 2023

Introduction.Climatic conditions of the Far North are a factor in the early development and progression of coronary artery disease. Aim. To study the clinical-anamnestic and laboratory-instrumental characteristics of patients with coronary artery disease living in the Far North and the temperate climate zone. Material and methods. An observational analytical study of 302 patients with coronary artery disease admitted to the hospital for coronary angiography was performed. Group 1 (n=168) included patients living in the Yamalo-Nenets Autonomous Okrug, group 2 (n=134) included patients living in the temperate climate zone. The clinical status of patients, drug therapy, laboratory data, and coronary angiography results were assessed. Student’s t-test, Mann-Whitney U-test, χ2 test or Fisher’s exact test were used when comparing indicators between the groups.. Results and discussion. In group 1, despite the younger age of patients, a history of myocardial infarction and chronic heart failure with a low left ventricular ejection fraction were more often recorded, which may be due to the so-called “polar tension syndrome”, which triggers pathological mechanisms of remodeling of the cardiovascular system. In elderly patients in group 2, hypertensive crises were more often recorded, and systolic blood pressure was higher and did not reach the target values. There were no differences in the nature of the lesion of the coronary bed. In both groups, a high incidence of hyperlipidemia was established and elevated levels of homocysteine, matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1, which are markers of atherosclerotic plaque instability and rapid progression of atherosclerosis, were registered. There were no differences in adherence to statin therapy, but the average dose of atorvastatin in group 2 was 2 times lower than in group 1. Group 1 patients were more adherent to taking antiplatelet agents, mainly due to middle-aged patients. Conclusion. In patients with coronary artery disease living in the Far North, despite their younger age, myocardial infarction and severe heart failure were more often found. All patients had a high incidence of hyperlipidemia and elevated levels of immune inflammation biomarkers. Regional differences in prescribed therapy and in the formation of patients’ adherence to treatment were revealed.
FEATURES OF DYNAMICS OF DISTURBANCES OF VIBRATION SENSITIVITY AND PAIN MANIFESTATIONS IN DISTAL SYMMETRICAL SENSORY-MOTOR POLYNEUROPATHY IN PATIENTS WITH DIABETES MELLITUS OF THE I AND II TYPES USING A LOW-FREQUENCY ALTERNATING MAGNETIC FIELD
Authors:   Kazan State Medical University, SAKOVETS TATYANA G. , BOGDANOV ENVER I. ,   Kazan State Medical University, BARYSHEVA ELENA N. ,   Clinical Hospital of the Medical Unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan
Published: October 2023

Introduction. Damage to peripheral nerve fibers in diabetes mellitus is considered the most severe complication that worsens the prognosis of the disease. Diabetic distal symmetrical polyneuropathy is detected in the vast majority of patients. A positive therapeutic response in patients with diabetic polyneuropathy can be obtained using low-frequency magnetic therapy. Aim. The aim was to determine the effectiveness of low-frequency magnetic therapy in the treatment of vibration sensitivity and pain manifestations in diabetic distal symmetric sensory-motor polyneuropathy in patients on insulin therapy. Material and methods. The study included patients with manifestations of diabetic distal symmetric sensory-motor polyneuropathy, who are on isulin therapy. All patients were observed before the start of therapy and after completion of the course of treatment. There were 20 patients in the control group, 19 patients in the main group. In the main group, low-frequency magnetotherapy was prescribed for 10 days. Patients with contraindications to physiotherapy treatment were included in the control group. Results and discussion. The absence of regression of moderate and severe disorders of vibration sensitivity in the control group was observed significantly with a higher frequency. The torpid course of mild disorders of vibration sensitivity was noted only in the control group. In patients experiencing deep pain in the lower extremities, complete regression of mild, moderate and severe pain was observed only in the main group. Only in the control group, a torpid course of moderate deep pain manifestations was observed. Moderate acute shooting pain in the lower extremities regressed completely in the main group with a significantly higher frequency compared to the control group. Only in the control group, there was a lack of dynamics of moderate acute pain, a feeling of moderate burning in the legs. In the main group, a complete regression of moderate discomfort in the legs in the form of a burning sensation was noted with greater frequency. Conclusion. In the treatment of disorders of vibration sensitivity and pain manifestations in distal symmetrical sensory-motor polyneuropathy in patients with diabetes mellitus of the I and II insulin-consuming types, it is advisable to use low-frequency magnetotherapy.
TECHNOLOGY, SCIENCE AND SPIRITUALITY IN THE 21ST CENTURY: A PHILOSOPHICAL ANALYSIS
Authors: Kipenskyi A. V. , Tararoev Yа.V.
Published: October 2023

The spontaneous, uncontrolled process of the development of technology, the transformation of modern science from the field of world research into an auxiliary means of maintaining technology, the loss of the spiritual image of a modern scientist as a selfless seeker of truth, raised the question of the study of the relationship between science and technology and the spirituality of humanity, as the main source of overcoming deviations development of man-made civilization. Considering various aspects of the relationship between spirituality and science and technology, the authors distinguish anthropological, acmeological and existential direction of interaction. The anthropological direction, which reveals the nature of the connection of spirituality, science and technology with the activity of the human brain, contains a cathartic, intellectual and moral aspect, aimed at the formation by means of modern education of a person who strives for scientific discovery, active application of the mind, overcoming manifestations of egocentrism , which affect the development of production and technology. Within the acmeological direction, the problem of choosing a modern development strategy, achieving the level of planetary and space civilization is considered. The existential direction is connected with the awareness of the crisis nature of the modern era, the main measures to preserve the Mind in the universe.
THE EFFECT AND COMPLICATION INDUCED BY ANTIHISTAMINE DRUGS IN THE LOCAL POPULATION; A CROSS SECTIONAL STUDY
Authors:   SamanShahab Farooqui, Sadiq Alveena
Published: October 2023

As we know that allergies all over the world is the utmost medical problem and in Karachi, Pakistan, every 2nd person is complaining of allergy due to pollution. Antihistamines are considered as one the most widely used and abused medications after analgesics. Antihistamines are generally used in the palliative treatment in allergic condition like hay fever urticaria. Some of pruritus, rhinitis, conjunctivitis, nasal discharge, mild asthma etc
VANCOMYCIN ASSOCIATED EOSINOPHILIA & RED MAN SYNDROMEIN A TERTIARY CARE HOSPITAL
Authors:   Zuhaib Jaffer Malik, Siddiqui Adeel
Published: October 2023

Vancomycin associated Red Man Syndrome (RMS) is a common infusion related adverse effect. A correlation has been proposed between vancomycin induced eosinophilia and occurrence of RMS.In such cases, it is identified that activated T-cells release cytokines, which tends to contribute to hypersensitivity reaction.A cross-sectional, retrospective study was conducted to evaluate the possible association of vancomycin induced eosinophilia with the occurrence of RMS at a local tertiary care cancer hospital
The Effect of Multiple Cycles of Surfactant-Alternating-Gas Process on Foam Transient Flow and Propagation in a Homogeneous Sandstone
Authors: Adebayo Abdulrauf R. , Rezk Mohamed Gamal , Badmus Suaibu O.
Published: October 2023

Years of laboratory studies and field tests show that there is still uncertainty about the ability of foam to propagate deep into a reservoir. Many factors have been identified as potential causes of nonpropagation, the most concerning being the lack of sufficient pressure gradient required to propagate foam at locations far from the point of injection. Most researchers that investigated foam propagation did so by coinjecting surfactant and gas. Coinjection offers limited information about transient foam processes due to limitations in the experimental methods needed to measure foam dynamics during transient flow. Foam injection by surfactant-alternating-gas (SAG) has proven to be more effective and common in field application. Repeated drainage and imbibition cycle offer a more favorable condition for the quick generation of foam. Foam can also be propagated at a lower pressure gradient in SAG mode. The objective of this study is to experimentally investigate how transient foam dynamics (trapping, mobilization, and bubble texture) change with multiple cycles of SAG and also with distance from the point of injection. A pair of X-ray source and receiver, differential pressure transducers, and electrical resistance sensors were placed along a 27-cm long, homogeneous, and high-permeability (KL = 70 md) Berea sandstone core. Foam was then generated in situ by SAG injection and allowed to propagate through the core sample under a capillary displacement by brine (brine injection rate = 0.5 cm3/min, Nca = 3×10-7). By use of a novel analytical method on coreflood data obtained from axial pressure and saturation sensors, we obtained trapped foam saturation, in-situ foam flow rates, apparent viscosities, and inferred qualitative foam texture at different core sections. We then observed the following: (i) Maximum trapped foam is uniform across the core sections, with saturation ranging from 47% to 52%. At the vicinity of foam injection, foam apparent viscosity is dominantly caused by gas trapping. At locations farther away, foam apparent viscosity is dominated by both gas trapping and refinement of foam texture. (ii) Cyclic injection of foam further enhances the refinement of foam texture. (iii) Textural refinement increases foam apparent viscosity as it propagates away from the point of injection. (iv) As the foam strength increases, the average gas flow rate in the core sample decreases from 0.5 cm3/min to 0.06 cm3/min. (v) There is no stagnation of foam as remobilization of trapped gas occurs during each cycle at an average flow rate of 0.002 cm3/min.
A survey of support for democratic policing of front-line police officers: focusing on the mediating effect of self-legitimacy
Authors:   Korean Association of Public Safety and Criminal Justice, Kim Seung hyun
Published: October 2023

Numerous studies have identified the impact of police self-legitimacy on support for democratic policing. In Korea, a study exploring legitimacy has been underway from the law enforcement's perspective since 2022. This study introduced the concept of police self-legitimacy, which employed a structural equation model analysis to evaluate whether a linear relationship could be predicted in a single model, with self-legitimacy as a mediator, between independent variables and dependent variables.
Among the independent variables only the relationship with citizens significantly affected the support for democratic policing. The impact of organizational justice and the relationship with superiors, however, was not exist. Among the mediator, it was evident that only self-assesed legitimacy influenced the support for democratic policing, whereas the effect of external legitimacy was not exist. Additionally, the study found that self-assessed legitimacy mediated the influence of citizen relationships on the commitment to support democratic law enforcement. Theoretically, it was anticipated that external legitimacy would exhibit a stronger connection with citizens. So, further exploration should be needed to understand the outcomes via indirect effects mediated by self-assessed legitimacy. This study offers the opportunity to shift the focus towards the normative aspects of law enforcement. By contrasting other viewpoints of both citizens and police police legitimacy, police legitimacy can be comprehended more systematically.
The Effect of Human Rights Education on Disabled Youth Human rights Behavior
Authors:   Korean Association of Public Safety and Criminal Justice, Lee Sodam , Shin Sora , Aum YooJin
Published: October 2023

As a result of the survey on human rights awareness in Korea, the disabled ranked second among the groups that are subject to human rights violations or discrimination. Human rights violations and discrimination against the disabled were the highest in the 2022 National Human Rights Commission of Korea's human rights survey. The respect for human rights of the disabled was significantly lower than that of the socially disadvantaged groups such as women, children, adolescents, and the elderly. In addition, it was found that education on human rights for the “disabled” is the most urgent among human rights education. As a first step toward not discriminating against the disabled, it is important to improve the perception of the disabled and the discrimination environment through human rights education. There are many studies on abuse of children with disabilities, but studies on school violence, human rights violations, and discrimination against children with disabilities are far from sufficient. While research on school violence targeting non-disabled children is highly interested, no separate research has been conducted on disabled students in the “School Violence Survey”. In particular, human rights violations and discrimination against children with disabilities affect even after graduation. In the case of discrimination against human rights violations, it is difficult to decide on a career path, as well as negative perceptions of employment, self-efficacy, and interpersonal skills are lower, and both social and daily life have difficulty adapting. Therefore, by examining the damage experiences of disabled children that have not been covered in the study of discrimination against human rights violations, this study attempted to analyze the impact of human rights education experiences on human rights violations and discrimination.
A Study of the Issues Surrounding the Passage of the Government(Ministry of Justice) Amendments to the Act on the Punishment of Stalking Crimes and Police Support for Victims
Authors:   Korean Association of Public Safety and Criminal Justice, Cho Je Seong , Hong Seong Cho
Published: October 2023

This study addresses issues regarding Act on the Punishment of Stalking Crimes(hereinafter referred to as the Stalking Punishment Act) that need to be considered once again even though the it has been passed as a government(Ministry of Justice) amendment. Although the Ministry of Justice’s amendment to the Stalking Punishment Act reflected the practical problems very well, the Delphi survey of the field and experts show that there are areas still need to be considered. As a result of the Delphi survey, it was found that there was no consensus on the abolition of Crime not Punishable against Victim's Will and the implementation of the Electronic Monitoring System, so even after the amendment, complementary institutional changes are required. Moreover, it is necessary for additional supplementation in order for handling stalking crimes and support and safety measures for victims to be carried out well. Therefore, through the results of the analysis, this study aims to identify the factors required for better handling stalking crimes and support and safety measures for victims, and to provide relevant recommendations so that each factor can be reflected in real world. To achieve the research objectives, this study conducted a regression analysis to examine the reasons for the lack of consensus on the two key words(Crime not Punishable against Victim's Will and Electronic Monitoring System) that were not agreed upon in the Delphi survey, and to identify factors that may affect the handling of stalking crimes and victim support with safety measures, limited to improving the work of stalling police officers. The regression analysis showed that the variables that had a negative impact on recommending punishment to unpunished victims were police experience (the longer the police career), heavy workload, and difficulty in dealing with passive victims. This result, with a model explanatory power of 43.6%, suggests that the police should consider reassigning personnel, work improvement, and an alternative to the avoidance of reporting of passive stalking victims due to the abolition of the Crime not Punishable against Victim's Will. Implications and specific policy recommendations will be discussed based on the analysis results.
T-AODV: a Trust-Based Routing against Black-hole Attacks in VANETs
Authors: Honarmand Farnam , Keshavarz-Haddad Alireza
Published: October 2023

Vehicular Ad Hoc Network (VANET) is a key component in the Intelligent Transportation System (ITS) with a number of applications for safety, traffic management, emergency services, entertainment, and so on. These applications are implemented by exchanging data among the nodes in an open, dynamic, and distributed fashion, and hence VANETs are vulnerable to different network attacks. For examples, DoS and black-hole attacks can be easily executed in VANETs, and strongly affect the routing protocol and its functionality. Through the nature of VANETs, trust management is considered one of the practical means to secure these networks. In this paper, we propose an up-to-date dynamic entity-centric trust model for VANETs, called T-AODV. We use social science techniques to apply weight and fuzzy logic theory and identify the malicious nodes. Our NS2 simulation results indicate that T-AODV can be more resists in contact with black-hole attacks by boosting the security of AODV routing protocol. T-AODV slightly increases the routing overhead of AODV and provides better performance than the existing I-AODV scheme.
Engineering Tripartite Gene Editing Machinery for Highly Efficient Non-Viral Targeted Genome Integration
Authors: Wu Hao , Nam Hangu , Xie Keqiang , Majumdar Ishita , Yang Shaobo , Starzyk Jakob , Lee Danna , Shan Richard , Li Jiahe
Published: October 2023

Non-viral DNA donor template has been widely used for targeted genomic integration by homologous recombination (HR). This process has become more efficient with RNA guided endonuclease editor system such as CRISPR/Cas9. Circular single stranded DNA (cssDNA) has been harnessed previously as a genome engineering catalyst (GATALYST) for efficient and safe targeted gene knock-in. Here we developed enGager, a system with enhanced GATALYST associated genome editor, comprising a set of novel genome editors in which the integration efficiency of a circular single-stranded (css) donor DNA is elevated by directly tethering of the cssDNA to a nuclear-localized Cas9 fused with ssDNA binding peptides. Improvements in site-directed genomic integration and expression of a knocked-in DNA encoding GFP were observed at multiple genomic loci in multiple cell lines. The enhancement of integration efficiency, compared to unfused Cas9 editors, ranges from 1.5- to more than 6-fold, with the enhancement most pronounced for transgenes of > 4Kb in length in primary cells. enGager-enhanced genome integration prefers ssDNA donors which, unlike traditional dsDNA donors, are not concatemerized or rearranged prior to and during integration Using an enGager fused to an optimized cssDNA binding peptide, exceptionally efficient, targeted integration of the chimeric antigen receptor (CAR) transgene was achieved in 33% of primary human T cells. Enhanced anti-tumor function of these CAR-T primary cells demonstrated the functional competence of the transgenes. The ‘tripartite editors with ssDNA optimized genome engineering’ (TESOGENASETM) systems help address the efficacy needs for therapeutic gene modification while avoiding the safety and payload size limitations of viral vectors currently used for CAR-T engineering.
Efficacy and Safety of Endoscopic subserosal dissection Treatment for Gastrointetinal submucosal Tumors in the Upper Gastrointestinal Tract
Authors: Wang Aili , Niu Qiong , Chen Yan , Liu Lijuan , Xiao Xin , Liu Chengxia
Published: October 2023

Objective
To investigate the safety and efficacy of endoscopic subserosal dissection for patients with submucosal tumors in the upper gastrointestinal tract.
Methods
This retrospective single-center study included 16 patients who underwent ESSD. All patients were enrolled from July 2018 to Dec 2021. Parameters such as demographics, size, resection margin, complications, pathological features, procedure time and follow-up were investigated and analyzed.
Results
Our study achieved 100% en bloc resection and 100% R0 resection. The most common location was the corpus with a mean tumor size of 2.78 ± 1.56 cm. The mean age, procedure time, were 53.4 ± 10.3 years, 85.31 ± 46.64 minutes respectively. Acocording to National Institutes of Health classification, 7 (13, 53.85%), 5 (13, 38.46%) ,and 1 (13, 7.69%) objects belonged to the very low, low, and intermediate classification, respectively. Immunohistochemistry results showed a 100% positive rate of CD34, DOG-1, CD117, and Ki67. A mean follow-up of 9.3 ± 2.5 months showed no recurrence or metastasis.
Conclusions
ESSD is effective and safe surgical procedure for curative removal of gastrointestinal submucosal tumors in the upper gastrointestinal tract, and it can be preferred for patients with no metastasis.
Association study between intestinal flora and renal malignancy based on genome-wide association analysis data
Authors: Gan JingZheng , Yuan Yuan , Wang Xiong , Luo PengCheng
Published: October 2023

Objective
Gut microbiome (GM) plays an important role in a variety of diseases, and renal malignancies have been shown to be closely associated with GM. However, the role of GM in the pathogenesis of renal malignancies has not been fully explored. The aim of this study was to investigate the potential causal association between intestinal flora and renal malignancies and the possible mechanisms of action.
Methods
We collected genome-wide association study (GWAS) data on GM and renal malignancies and applied Mendelian randomization (MR) analysis to explore the causal association between them.
Results
By MR analysis, we found that GM components associated with renal malignancies, including enterobacteria of certain orders, families, and genera, may have negative causal effects in the pathogenesis, while enterobacteria of other orders, families, and genera may have positive causal associations with renal malignancies.
Conclusion
This study reveals a possible causal association between intestinal flora and renal malignancies and identifies several genetic variants involved in this association. These findings are expected to provide new insights into the pathogenesis of renal malignancies and provide a theoretical basis for the development of therapeutic strategies targeting intestinal flora in the future.