bluuebunny/crossref_metadata_2025 huggingface dataset:
Authentic video materials as a means of shaping communicative competence in Russian among Spanish and Dutch learners
Authors: Gorozhankina Tamara Nikolaevna , Grechukhina Vera Viktorovna
Published: January 2023

Teaching Russian as a foreign language (RFL) without immersion into a natural language environment presents a particular challenge and requires modern methods to deve-lop basic communicative and linguistic competencies of the students. While teaching listening at the first stage of learning a foreign language, an active use of authentic materials plays an important role as one of the major requirements of the communicative approach. The relevance of the present topic consists in the need of developing listening skills at the early stage of studying RFL and optimizing the work of students as independent learners. The aim of the study was to develop a set of video exercises for A0 level, aimed at improving the communicative competence of students, their knowledge of cultural norms and speech etiquette. To achieve this aim,a set of methodological methods has been used: a task modeling method, a comparative method and observation. The complete set of exercises was tested in groups of students aged 20-45, learning Russian as a foreign language at beginner’s level at two language centers, in Spain and in the Netherlands. Exercises with video fragments were divided into six units and were designed to practice the use of some grammar forms and lexical units (verbs belonging to the first and second conjugation type, prepositions в/на (in, on), accusative and prepositional cases).For independent work, students were asked to complete the preparatory and main stages of each unit. The final stage, as a control stage, was carried out in the classroom with a teacher to activate the structures heard in listening, analyze and discuss the video material. The results ofthe study show that the use of authentic materials improves listening, brings the educational process as close as possible to the situation of real live communication, motivates students and helps them to master the new grammatical and lexical units. There were no significant differences observed in the results of the final task on listening in Spanish and Dutch groups. The errors have to do with an increased speed of utterance, voice overlapping, children's speech, that will be taken into account for the further development of listening exercises for A0 level students and publishing a full set of exercises for RFL learners and teachers.
Linguodidactic potential of semiotically heterogeneous texts in teaching Russian to Kazakh schoolchildren
Authors: Zhapparkulova Karlygash N. , Tuyembayev Zhanseit K. , Dzholdasbekova Bayan U.
Published: January 2023

The authors characterize functioning of semiotically heterogeneous texts in the methodology of teaching the Russian language. Traditional methods of applying semiotically heterogeneous texts in the educational process are still important, but at the same timeit is necessary to transform the scientific approaches to analysing the problems caused bythe reflexive nature and situational variability of digital content in education. The aim ofthe work is to identify and describe the linguodidactic potential of semiotically heterogeneous texts used in Russian language classes in Kazakhstan schools. Methods of comprehensive theoretical analysis of scientific and educational literature on semiotically heterogeneous texts, as well as observational method of studying and summarizing the pedagogical experience of Russian language teachers in Almaty schools were used. The printed semiotically heterogeneous texts from the series of textbooks on the Russian language and literature ofthe Kazakh language school (7th, 8th, 9th grades), as well as the video clips of literary miniatures by E. Posashkova on Youtube channel were chosen as the sources for the study material. It was proved that the linguodidactic potential of semiotically heterogeneous texts is disclosed on the basis of a system of special tasks and exercises. The authors’ method of analysing semiotically heterogeneous texts in Russian language classes in Kazakhstan schools is offered. Their linguodidactic potential aimed at memorizing the main content of the text, developing the skills in the main types of speech activity and language aspects, influencing the students’ imagination, emotions, subconsciousness, ensuring the productivity of communication in the new information and communication environment is revealed. Prospective for the study is the study of the functional load of variative components of semiotically heterogeneous texts, their hypertextual connections and implementation in teaching Russian in Kazakh schools.
Teaching Russian to Uyghurs in PRC universities: pedagogical toolkit of nationally oriented methods
Authors: Strelchuk Elena N. , Ilikhamu Shabaaiti
Published: January 2023

The relevance of the study is determined by the search for a compromise in teaching the Russian language to the Uighurs in the universities of PRC. Having completely different mental, cultural and linguistic traits, the Uyghurs and the Chinese study in programs that are focused only on the Chinese audience and do not take into account the characteristics of national minorities. The purpose of this study is to consider the basics of a nationally oriented methodology for teaching Russian to Uyghurs in Chinese universities and to propose its pedagogical tools. The materials were the works of scientists on nationally oriented education and methods of teaching Russian as a foreign language, works on the history and culture of the Uyghur people, as well as a survey of Uyghur students and teachers studying and working at Beijing State University. Methods of complex theoretical analysis and questionnaire-diagnostic were used. The cultural and historical path of the Uighurs was analyzed, which determined their mental characteristics, which must be taken into account when developinga nationally oriented methodology. The results of the survey made it possible to identifythe specifics of teaching the Uyghurs the Russian language and to characterize the main difficulties that students face in universities in the PRC. Ways of solving the indicated difficulties were determined by developing a nationally oriented methodology for teaching the Uyghurs the Russian language and its pedagogical tools were proposed. The prospects of the research are the approbation of the proposed foundations for the nationally oriented teaching of the Uighurs in the Russian language in the universities of the PRC and their further development.
A Case Report of Bruxism and Its Management with The Help of Occlusal Splints.
Authors: Mukram Ali Fareedi , Abdullah Alsheri Mesfer Ibrahim , Abdullah Shami Shumua Mahmoud , I. Mohana Arwa Jabar , Ibrahim Abujamilah Esraa Eissa , Abduallah Alshehri Fahad Ali
Published: January 2023

Bruxism is considered a normal habit, but in case of certain circumstances like increased frequency of episodes and strength of the masticatory muscles, it can turn into a pathological phenomenon. Bruxism is an umbrella term for the parafunctional habits of grinding and clenching teeth. It can occur during wakefulness (clenching) or sleep (bruxism). A 31-year-old male patient complained of severe loss of coronal tooth structure in the upper anterior region of the jaw. Medical, drug and social history were within normal limits. However, clinical examination revealed maxillary anterior teeth showing severe "attrition", while other teeth had less attrition and infrequent pain in the temporomandibular joint with a clicking sound. By thorough examination and history of the patient, the diagnosis of the bruxism was made, and the patient was planned for the treatment with the help of a permissive occlusal splint. Occlusal splint therapy is used to stabilize the "TMJ " and protect the teeth, relax the masseter and temporalis muscles, increase inter-vertebral and inter-discal space, and allow the balance of bite forces and decrease bruxism activity. Therefore, early diagnosis and treatment can prevent the consequences of the breakdown of dentition and orofacial pain. This case report presents the successful treatment of occlusal splint therapy in patients with severe bruxism.
Green Synthesis and Applications of Silver Nanoparticles Using Plant Extracts: A Review Article
Authors: Akshay  , Verma Anchal , Saroha Akshay , Garg Rajeev
Published: January 2023

The nanoparticle (NP) biosynthesis field is still underdeveloped and has long been known to impact many industries significantly. Recently, the synthesis of silver NPs has been given excessive attention in developed countries because of the requirement to develop environmental supporter technologies to synthesize materials. The uses of green chemicals are environmentally friendly, non-poisonous, and inexpensive. It has been shown that various microbes, including yeast, fungi, bacteria, and plants, can synthesize intracellular and extracellular AgNPs. All systematic information reflects the unique possessions of AgNPs, which have many uses such as antifungal, antibacterial, anticancer, and antiviral agents, brilliant natural catalytic larvae, dyedegrading, excellent antioxidants, treatment of complications associated with diabetes, and wound curative. Physical and chemical methods use high radiation levels and high concentrations of reducing agents and stabilizers that are dangerous to the environment and human health. Therefore, the synthesis of NPs is a one-step bioremediation approach and consumes low energy for an environmentally friendly synthesis of NPs. Recently, the development of effective green chemistry methods using reducing agents, limiters, and natural stabilizers to obtain AgNPs of good shape and sizes has become an area of research. This review aims to explore the green synthesis of silver nanoparticles using plant extract, and the characterization of synthesized silver nanoparticles with their different applications. Also, this review is meant to tell about the plants and their various parts that can be used for the green chemistry of silver nanoparticles in an environmentally friendly basis with their many therapeutic applications. Finally, this review summarizes the latest published data that can be used for research.
Analisis Metode Weighted Product untuk Menentukan Mahasiswa Terbaik
Authors: Ramadhan Rizal Furqan
Published: January 2023

Mahasiswa merupakan keluaran dari tingkatan pendidikan tinggi dalam sebuah perguruan tinggi. Para mahasiswa yang saat ini belajar di Perguruan Tinggi, harus disiapkan menjadi pembelajar sejati yang terampil, lentur dan ulet (agile learner). Kemampuan mahasiswa dibangku kuliah cukup menentukan masa depannya, apalagi di era sekarang ini persaingan kerja sangatlah ketat. Kedepan, lulusan perguruan tinggi tidaklah cukup hanya dengan bermodalkan ijazah sebagai syarat administratif namun juga harus memiliki kemampuan penunjang lain sebagai pendukung. Pihak perguruan tinggi haruslah membuat sebuah terobosan untuk memancing para mahasiswa untuk meningkatkan prestasi mereka baik dalam bidang akademik maupun non akademik supaya mampu bersaing di dunia kerja. Pihak perguruan tinggi pun harus mulai kreatif dan inovatif dalam melaksanakan penilaian mahasiswa terbaik tersebut yang harus disesuaikan dengan perkembangan zaman saat ini. Era saat ini merupakan era digital yang terus berkembang. Metode komputasi seperti Weighted Product  merupakan salah satu metode komputasi yang efektif untuk melakukan penilaian mahasiswa terbaik. Metode ini menggunakan teknik pangkat untuk menghitung beberapa komponen penilaian yang disesuaikan dengan kriteria. Pemilihan kriteria berdasarkan dari pakar atau dalam hal ini adalah pihak Gugus Jaminan Mutu Fakultas. Data yang digunakan adalah data mahasiswa Fakultas Ekonomi dan Bisnis Islam Universitas Islam Negeri Sayyid Ali Rahmatullah Tulungagung dari berbagi program studi dalam tingkatan semester yang sama. Hasil keluaran dengan menggunakan metode ini adalah mahasiswa dengan prestasi akademik maupun non akademik mulai tertinggi sampai terendah bisa diketahui sesuai dengan angka masukan yang telah diproses menggunakan metode Weighted Product.
Implementasi Chatbot Untuk Rekomendasi Tema Tugas Akhir Program Studi Informatika Menggunakan Metode Simple Additive Weight
Authors: Aryanto Salam , Honggowibowo Anton Setiawan , Akhmad Jabbar
Published: January 2023

Many of courses that have been taken makes it difficult for students to determine one area to focus on in determining the theme of the final project. The case study of this research is the Informatics Study Program at the Adisutjipto Aerospace Technology Institute, Yogyakarta. For this reason, a chatbot with a decision support system was made using the simple additive weighting (SAW) method which adds up the weights of the performance of each object that is different and has the same opportunity on all the criteria it has. This method requires the process of normalizing the decision matrix (X) to a scale that can be compared with all existing alternative ratings. The number of observation scores is the sum of the scores of each observation statement multiplied by the weight of the score according to the Likert scale. The maximum score is the maximum score on the Likert scale multiplied by the number of questions, so 5 x 9 = 45. The expected score is the maximum score multiplied by the number of respondents, so 45 x 30 = 1,200. Based on the feasibility test of the chatbot system for the final project recommendation using this method, it succeeded in calculating the feasibility of an application of 1074 (89.5%) with the formula for calculating the percentage of eligibility which was tested by 30 students of the 2017 class of Informatic Study Program, Adisutjipto Aerospace Technology Institute.
Mendeteksi Keamanan Website SMP Negeri 1 Blahbatuh Menggunakan Metode Open Web Application Security Project (OWASP) Versi 2.11 XSS & Rate Limiting
Authors: Januraga I Made Agus Jana , Wijaya Gede Bagus Parmadi , Patrick Laurensius , Listartha I Made Edy
Published: January 2023

Mendeteksi kerentanan situs web adalah hal yang sangat penting dan dapat memperkirakan risiko yang ada pada keberlangsungan suatu organisasi. Terjadinya transisi ke dalam lingkup situs web dimanfaatkan oleh beberapa kejahatan dengan tujuan mencuri informasi rahasia pengguna demi keuntungan diri sendiri. Pada Penelitian ini dilakukan mekanisme metode asesmen risiko pada situs web SMP Negeri 1 Blahbatuh. situs web tersebut merupakan situs web resmi dari sekolah untuk mengikuti kegiatan belajar mengajar yang dikelola oleh pihak sekolah. Untuk mengetahui risiko situs web, maka digunakannya metode Open Web Application Security Project (OWASP) XSS dan Rate Limiting untuk mendeteksi kerentanan pada situs web.XSS atau lebih dikenal dengan Cross Site Scripting merupakan suatu serangan yang melakukan kode injeksi dengan menggunakan halaman situs suatu aplikasi. Pelaku kejahatan dari XSS atau Cross Site Scripting ini melakukan aksinya dengan cara mengeksekusi skrip pada browser korban dengan cara memasukkan kode berbahaya pada halaman webnya. Rate limiting atau yang biasa digunakan untuk tarif suatu bentuk strategi yang digunakan untuk melakukan uji coba kerentanan keamanan lintas web tersebut atau serangan jaringan.ini dapat berguna untuk membatasi kali tersebut berulang berulang kali dalam jangka waktu tertentu.mencoba masuk ke situs web sekolah dengan login di halaman situs webnya menggunakan akun yang acak sampai batas yang telah ditentukan contohnya untuk menguji seberapa aman situs web tersebut. ont
PENGEMBANGAN SISTEM REKOMENDASI ATLET ESPORTS BERDASARKAN PREDIKSI ELO RATING MENGGUNAKAN MODEL STOCHASTIC GRADIENT BOOSTING
Authors: Setiawan Rudi , Wibowo Achmad Teguh , Ridwan Mujib
Published: January 2023

Indonesia memiliki tantangan bonus demografi dengan jumlah yang cukup besar. Tantangan tersebut dapat dimanfaatkan sebagai kesempatan yang baik khususnya untuk mendulang potensi Esports Indonesia. Sebanyak hampir seperempat total penduduk Indonesia dikategorikan sebagai penggiat video game dari populasi urban online. Namun potensi tersebut terhambat oleh kendala para pegiat esports yang kesulitan untuk menbentuk sebuah tim. Dalam penelitian ini mengembangkan sistem rekomendasi atlet esports untuk membantu para atlet dalam membentuk tim yang cocok. Dalam membuat sistem rekomendasi atlet dibutuhkan kecocokan antar atlet maka hal ini dapat diselesaikan menggunakan prediksi penilaian ELO Rating. Permasalahan prediksi ELO Rating dapat diselesaikan dengan model regresi Stochastic Gradient Boosting (SGB). Untuk menguji nilai prediksi, menggunakan Root Mean Squared Error (RMSE) dan performa berdasarkan waktu dengan satuan detik sebagai acuan. Dengan skenario pengujian data training berbanding dengan data testing dengan rasio 90%:10%, menghasilkan RMSE Testing sebesar 17.7422 dan RMSE Training sebesar 16.9820 sehingga model ini tidak mengalami overfitting dikarenakan memiliki selisih yang kecil yaitu sebesar 0.7602 serta memakan waktu pelatihan sebesar 8.6720 detik.
RANCANG BANGUN GAME PLATFORM 2D PETUALANGAN SI GAJAH BERBASIS ANDROID
Authors: Hakim Kharis Furqonnil , Pasha Donaya , Adrian Qadhli Jafar
Published: January 2023

Game merupakan salah satu aktivitas yang dilakukan oleh sebagian orang untuk mencari hiburan dan kesenangan sebagai penghilang rasa bosan. Seiring berjalannya waktu, perkembangan teknologi informasi dan komunikasi saat ini berkembang dengan sangat pesat di berbagai bidang, salah satunya perkembangan game. Game tidak hanya digunakan sebagai hiburan, akan tetapi game juga bisa sebagai media belajar, lahan bisnis, dan sebagai cabang olahraga. Game memiliki beberapa genre yaitu, First Person Shooter, Fighting Game, Racing Game, Role Play Game, Multiplayer, Adventure, Simulasi, Strategi, dan Platform. Penelitian ini bertujuan untuk menghasilkan Rancang Bangun Game Platform 2D Petualangan Si Gajah Berbasis Android. Hasil dari penelitian ini menciptakan sebuah game cukup menantang dan melatih kesabaran bagi yang memainkannya. Dalam pembuatannya, diperlukan metode pengembangan sistem yang sesuai, supaya game yang akan dibangun sesuai dengan yang diinginkan. Peneliti menggunakan metode pengembangan sistem Game Development Life Cycle. Hasil uji kelayakan game dengan menggunakan metode pengujian ISO 25010 pada aspek functional suitability sebesar 100%, pada aspek usability sebesar 90,34%, dan pada aspek portability sebesar 100%.
Penerapan Algoritma KNN, Naive Bayes Dan C4.5 Dalam Memprediksi Kelulusan Mahasiswa
Authors: Wati Embun Fajar , Rudianto Biktra
Published: January 2023

Seleksi penerimaan mahasiswa baru berfungsi untuk mendapatkan mahasiswa yang berkualitas. Kualitas mahasiswa dapat diukur dengan masa pendidikan di perguruan tinggi. Lulusan yang tepat waktu yang mempunyai predikat mahasiswa berkualitas. Jumlah kelulusan mahasiswa sangat mempengaruhi penilaian akreditasi bagi suatu perguruan tinggi. Banyak faktor yang sangat berpengaruh terhadap ketepatan waktu kelulusan bagi mahasiswa seperti, jenis kelamin, umur, status pernikahan, IPK, dan status pekerjaan. Kelima faktor inilah yang akan dijadikan variabel input dalam menentukan klasifikasi kelulusan mahasiswa. Variabel-variabel tersebut akan diolah dengan algoritma KNN (K-Nearest Neighbor), Naive Baye, C4.5. Data mahasiswa diseleksi sebanyak 300 mahasiswa. Data preprocessing menggunakan data mahasiswa yang terdiri dari data pribadi (jenis kelamin, umur, status pernikahan, dan status pekerjaan) dan data akademik (IPK). Berdasarkan data kelulusan, 203 siswa lulus tepat waktu dan 97 siswa lulus terlambat.Setelah dilakukan transformasi, keseluruhan data dapat digunakan karena tidak ada nilai yang kosong. Data yang diubah adalah umur (muda : 19 - 24, tua : 25 - 50) dan IPK (besar : 3 - 4, kecil : 1 - 2.9). Hasil confusion matrix, menunjukkan bahwa Naive Bayes mempunyai accuracy 100.00% dan AUC 1.000 lebih tinggi dibandingkan dengan C4.5 dan KNN. Sehingga algoritma Naive Bayes mempunyai kinerja yang lebih baik dibandingkan dengan KNN dan C4.5.
Resident Physician Interactions and Engagement With Written Assessments of Performance
Authors: Figg Bethany J. , Bolen Olivia , Wagner Mary Jo , Hicks Troy , Santen Sally A.
Published: January 2023

Background and Objectives: Despite the requirements of the Accreditation Council for Graduate Medical Education (ACGME) to provide feedback, assessments are often not meeting the needs of resident learners. The objective of this study was to explore residents’ approach to reviewing, interpreting, and incorporating the feedback provided in written faculty assessments.
Methods: We conducted semistructured interviews with 14 family medicine residents. We used line-by-line iterative coding of the transcripts through the constant comparative method to identify themes and reach a consensus.
Results: The study revealed the following themes: (1) residents value the narrative portion of assessments over numerical ratings, (2) performance reflection and reaction are part of the feedback process, (3) residents had difficulty incorporating formal assessments as many did not provide actionable feedback.
Conclusions: Residents reported that narrative feedback gives more insight to performance and leads to actionable changes in behaviors. Programs should consider education for both faculty and residents on the usefulness, importance, and purpose of the ACGME Milestones in order to accurately determine resident competency and provide a summative assessment. Until the purpose of the ACGME Milestones is realized and utilized, it should be noted that the comment portion of evaluations will likely be the focus of the resident’s interaction with their assessments.
Improving First-Year Family Medicine Residents’ Confidence in Safe Opioid Prescribing Through a Multiactivity Educational Program
Authors: Ofei-Dodoo Samuel , Beard Sheryl , Curry Amy E. , Shin Tiffany R. , Nutting Ruth
Published: January 2023

Background and Objective: It is documented that some of the opioids prescribed to manage chronic pain are diverted and used for nonmedical purposes. We investigated whether a skill-based, chronic pain management (CPM) educational program could improve first-year family medicine residents’ comfort, knowledge, and concerns in assessing and managing patients who use opioids for chronic noncancer pain.
Methods: A total of 72 first-year residents (four cohorts of 18) participated in a 3-month CPM training intervention that consisted of didactic lectures, objective structured clinical examination (OSCE) activities, and post-OSCE debriefing with faculty, one being a behavioral health specialist, between 2017 and 2020. We used a single-sample, pre/post design. At three points in time (baseline, 3-months, and 6-months postintervention), participants completed a set of measures assessing comfort, knowledge, and concern. We used repeated measures analyses to assess changes in outcome measures.
Results: Participants reported improvements compared with baseline at both follow-up time points. At 6 months postintervention, the participants had significantly better scores on measures of comfort (F[1, 71]=65.22; P<.001), knowledge (F[1, 71]=22.38, P<.001), and concern (F[1, 71]=37.89, P<.001) in prescribing opioids for chronic noncancer pain.
Conclusion: A multiactivity CPM educational program for first-year residents was associated with improvement in perceived sense of comfort, knowledge, and concerns in assessing and managing patients who use opioids for chronic noncancer pain. CPM training interventions may be an effective tool to educate first-year residents to implement best practices for pain management with the goal of reducing the chances of inappropriately prescribing controlled substances or denying analgesia.
Supplemental Offer and Acceptance Program Outcomes in a Family Medicine Residency Network
Authors: Chen Frederick , Weidner Amanda , Ormsby Molly , Maier Russell
Published: January 2023

Background and Objective: The National Resident Matching Program’s (NRMP) Supplemental Offer and Acceptance Program (SOAP) places unmatched applicants in residency programs. We examined the outcomes and experience of family medicine residency programs that matched with residents through SOAP.
Methods: In 2020, all program directors in a regional family medicine residency network whose programs had participated in SOAP (n=23) completed a survey on their experience with SOAP and characteristics of residents who were matched via SOAP (n=52) anytime between 2012 and 2020. Resident outcome measures included graduation, remediation, leadership, fit, and comparisons of Milestones areas. Experiences with the SOAP process included factors that may have led the program to SOAP and advice for other programs participating.
Results: Eighty-seven percent of residents matched via the SOAP graduated, and the majority compared favorably to other residents. Two-thirds of program directors were very likely to hire their residents matched via the SOAP. Rural programs had similar outcomes, although rural-track positions represented 30% of all residents matched via the SOAP in the study. More than half of all responding program directors reported being underprepared for the SOAP process. Program directors recommend getting familiar with the NRMP resources and setting aside time for key personnel in case a program needs to participate in SOAP.
Conclusions: The vast majority of residents matched via the SOAP are well prepared for training, contribute to their programs, and perform as well as other residents. Rural programs are more likely to place residents via SOAP than nonrural programs.
THE APPRAISAL SYSTEM OF HYPERBOLIC EXPRESSIONS IN SETIYONO'S 'GLONGGONG' NOVEL TRILOGY
Authors: Wijaya Rahmaditya Khadifa Abdul Rozzaq
Published: January 2023

This study aimed to find out the appraisal system in the hyperbolic figure of speech. is a qualitative-descriptive study with data in the forms of words, phrases, and clauses indicating hyperbolic figurative language and having appraisal systems. The sources of data were the novel trilogy entitled Glonggong that consists of Glonggong, Arumdalu, and Dasamuka. For collecting the data, focus group discussion and content analysis were applied, whereas for analyzing the data, it used Spradley’s Ethnography Method comprising domain, taxonomy, componential, and cultural theme analysis consecutively. The result of this study show that hyperboles as a type of figurative language in the narratives and dialogues of the novel have appraisal systems in the forms of attitude, graduation, and source.
HSV Encephalitis: An atypical presentation of delirium
Authors: Wan Nicholas Ming Hao , Weerakkody Sanath
Published: January 2023

Herpes Simplex Encephalitis is the most common cause of infectious
encephalitis. Our case is of a 75-year-old woman who presented with
dysuria and altered mental status. Our case addresses the difficulties
in diagnosis and highlights the importance of early recognition of HSE
and its associated neurological sequelae.
Automated calibration and in-line measurement of product quality during therapeutic monoclonal antibody purification using Raman spectroscopy
Authors: Wang Jiarui , Chen Jingyi , Hubbuch Juergen , Studts Joey , Wang Gang
Published: January 2023

Current manufacturing and development processes for therapeutic
monoclonal antibodies demand increasing volumes of analytical testing
for both real-time process controls and high-throughput process
development. The feasibility of using Raman spectroscopy as an in-line
product quality measuring tool has been recently demonstrated and
promises to relieve this analytical bottleneck. Here, we resolve manual
calibration effort by engineering an automation system capable of
collecting Raman spectra on the order of hundreds of calibration points
from two to three stock seed solutions using controlled mixing. We used
this automated system to calibrate multi-product quality attribute
models that accurately measured product concentration and aggregation
every 9.3 seconds using an in-line flow-cell. We demonstrate the
application of a non-linear calibration model for monitoring product
quality in real-time during a biopharmaceutical purification process
intended for clinical and commercial manufacturing. These results
demonstrate potential feasibility to implement quality monitoring during
GMP manufacturing as well as to increase CMC understanding during
process development, ultimately leading to more robust and controlled
manufacturing processes.
The generalized polytropic model for the Sun-like stars
Authors:   Ivan Franko National University of Lviv, Vavrukh M. , Dzikovskyi D. ,   Ivan Franko National University of Lviv
Published: January 2023

The Eddington method based on simultaneous consideration of gas and light pressures with a homogeneous сhemical composition of stellar matter was generalized for the case of model with a spatially inhomogeneous chemical composition. As a result, it was obtained the equation of state, which is expressed by a generalized polytrope with index n=3. As an example, it was solved the equilibrium equation for the Sun both using the standard polytropic equation of state and generalized polytrope. The coordinate dependence of the Sun characteristics was calculated within two models. Obtained results are compared with the results of numerical calculations for the Sun based on the system of Schwarzschild equations for the standard model. It was shown that the standard polytropic model is applicable only for the Sun of zero-age. The Sun characteristics calculated with help of generalized equation of state are close to the results of numerical calculations based on Schwarzschild equations. It was concluded that the standard polytropic model is applicable for the stars of zero-age main sequence, and the generalized model – for the stars of finite age, in which thermonuclear reactions have already created a significant spatially inhomogeneity of chemical composition inside of the core.
A continuous SIR mathematical model of the spread of infectious illnesses that takes human immunity into account
Authors:   Laboratory of Analysis Modeling and Simulation, Casablanca, Morocco, Khaloufi I. , Lafif M. ,   Laboratory of Analysis Modeling and Simulation, Casablanca, Morocco, Benfatah Y. ,   Laboratory of Analysis Modeling and Simulation, Casablanca, Morocco, Laarabi H. ,   Laboratory of Analysis Modeling and Simulation, Casablanca, Morocco, Bouyaghroumni J. ,   Laboratory of Analysis Modeling and Simulation, Casablanca, Morocco, Rachik M. ,   Laboratory of Analysis Modeling and Simulation, Casablanca, Morocco
Published: January 2023

A mathematical model of infectious disease contagion that accounts for population stratification based on immunity criteria is proposed. Our goal is to demonstrate the effectiveness of this idea in preventing different epidemics and to lessen the significant financial and human costs these diseases cause. We determined the fundamental reproduction rate, and with the help of this rate, we were able to examine the stability of the free equilibrium point and then proposed two control measures. The Pontryagin's maximum principle is used to describe the optimal controls, and an iterative approach is used to solve the optimality system. Finally, numerical simulations are carried out in MATLAB to verify the theoretical analysis.
Study of Hopf bifurcation of delayed tritrophic system: dinoflagellates, mussels, and crabs
Authors:   Analysis, Modeling and Simulation Laboratory, Hassan II University, Morocco, Hafdane M. , Agmour I. ,   Analysis, Modeling and Simulation Laboratory, Hassan II University, Casablanca, Morocco, El Foutayeni Y. ,   Analysis, Modeling and Simulation Laboratory, Hassan II University, Morocco; Unit for Mathematical and Computer Modeling of Complex Systems, IRD, France
Published: January 2023

In this paper, we have a discrete delayed dynamic system of three marine species: prey, predator, and superpredator. In addition to the effect of prey toxicity, we consider the negative fishing effect of these species. The study of this model consists of the search for equilibria with eigenvalue analysis, the existence of Hopf bifurcations at interior equilibria, and the determination of direction and stability analysis of Hopf bifurcation using the theory of normal form and center manifold. Some examples are given with numerical simulations to illustrate the results in different cases of delay.
Pengaruh Penambahan Kitosan dalam Pembuatan Biodegradable Foam Berbahan Baku Pati
Authors: Hendrawati Nanik , Lestari Yulia Irna , Wulansari Putri Anggraini
Published: January 2023

Biodegradable foam is an alternative packaging to replace the expanded polystyrene foam packaging currently in use.   Starch has been used to produce foam because of  its low cost, low density, low toxicity, and  biodegradability. Chitosan has been added to improve mechanical properties of product . The   effect of  variation on chitosan amount  and  starch types  was investigated in this study.  The amount of  chitosan  was varied as 0; 5; 10; 15; 20; 25; and  30 % w/w and starch types were used in this research were cassava, Corn and sago starch. Biodegradable  foam was produced by using baking process method, all of material (Starch, Chitosan solution,  Magnesium Stearate, Carrageenan, Glyserol, Protein Isolates  dan polyvinil alcohol (PVOH)  were mixed with kitchen aid mixer. The mixture was poured  into mold and heated in an oven at 125 oC for 1 hour. Then, foam was tested for its mechanical properties, water absorption  and biodegradability and  morphology (SEM).  The results show that  foam made from sago starch had lower water absortion than those made from cassava and corn starch.   While, foam made from cassava starch  was more biodegradable than the other foam.  Biodegradable foam based sago starch and 30 % w/w of Chitosan adition  gave the  best performence in tensile stress that  is 20 Mpa
The Heat Resistant Capabilities of Bioplastic Composites on Sago Hampas Starch-Al2O3
Authors: Amatullah Afra Najiyah , Kemala Tetty , Irawadi Tun Tedja
Published: January 2023

Sago hampas are a waste with a high starch content. The starch from sago hampas can be used as a raw material for bioplastics. However, because bioplastics have a lower heat resistance than conventional plastics, additives are required to increase heat resistance. Aluminum oxide can be used as a metal compound that acts as an additive to increase heat resistance. Bioplastics were created using a weight percentage of 0, 1, 3, and 5% Al2O3. DTA was used to determine the melting point of bioplastics, as well as their mechanical properties, density, and water resistance. The best results were identified using FTIR and SEM. The results showed that adding Al2O3 at 1, 3, and 5% increased the heat resistance of bioplastics with melting points of 270, 274, and 280 oC. Except for mechanical properties, the best results were obtained with a melting point of 280 oC, tensile strength of 3.41 Mpa, elongation of 38.66%, density of 5.52 g cm-3, and 80.28% water resistance for bioplastics with 5% Al2O3 that suitable on Indonesian National Standard 7188.7:2016. The FTIR analysis revealed that bioplastics containing Al2O3 experienced physical interactions. Morphological analysis revealed that Al2O3 was evenly distributed on the bioplastic's surface.
Characterization and Application of HCl-Activated LTA Zeolite from Lampung Natural Zeolite (LNZ) for Bioethanol Purification
Authors: Ginting Simparmin Br , Wardono Herry , Islamia Ulfa , . Darmansyah
Published: January 2023

Lynde Type-A (LTA) zeolite as being molecular sieve and hydrophilic zeolite is used to dehydrate water in the purification of bioethanol. LTA zeolite from LNZ has a small surface area of 29,62 m2/g. Adding HCl activators to LTA Zeolite from LNZ was carried out to increase the surface area of LTA zeolite. The activation of LTA zeolite  was carried through in a closed erlemeyer with various HCl concentration: 10% w/w, 15 % w/w, and 20% w/w and the ratio acid/LTA zeolite was 10 ml: 1 gram. The XRD analysis showed that the structure of LTA zeolite activated does not change despite the process of activation, and the highest percentage of crystallinity was obtained at 68.25% wt by concentration of HCl at 20 % w/w.  The result of XRF analysis showed that the highest of impurity removal and the highest of decreasing ratio of Si/Al was in the LTA zeolite activated by HCl 20% w/w. The result of BET analysis showed the largest surface area at 45.67 m2/g obtained by adding 10% w/w of HCl activator, which was 45.67 m2/g, and the size of zeolite’s pore volume was 0.027 cc/g.  The result performance of LTA zeolite activated  obtained the highest purity of bioethanol by  99.74 % v/v at HCl  concentration 20% w/w.
ANALYSIS OF WATER QUALITY AND QUALITY STATUS IN ACEH RIVERS BASED ON ENVIRONMENTAL POLLUTION INDEX
Authors: Rahmadi Dicky , Machdar Izarul , Syaubari Syaubari
Published: January 2023

The rapid development of industrialization and urbanization in the world impact increased water pollution. Human activities, such as dam constructions, excessive water consumption, severance of river flows, compaction of riverbanks, and excessive use of riverbed vegetation, disrupt river flow and alter the original hydrological cycle. In response to these conditions, this study aims to analyze water quality and river quality status to set up a watershed environmental management strategy in Aceh Province as a case study. River water quality was analyzed descriptively by comparing the results of laboratory tests with parameters, namely TSS, pH, BOD, COD, DO, total phosphate, nitrate, and fecal coli. These parameters were then transformed into the environmental index (Water Quality Index and Pollution Index). It was found that Water Quality Index (WQI) results are shown from 50 to 70. WQI with the Good category is at Kr. Weh which is in the Central Aceh city. The medium-less type is found in 10 watersheds. The water quality with the category of Less is found at 3 points, namely Kr. Aceh, Cr. Doy, and Cr. Daroy. The quality of the river water in the Aceh region, from upstream to downstream, has decreased in quality with a lightly polluted status based on the Minister of Environment and Forestry of the Republic of Indonesia No. 27 of 2021 for class II.
Trade Openness and Regional Inequality: Case of Tunisia
Authors: Younes Hamza Ben , Ameur Fayçal Ben
Published: January 2023

Since the 1990s, Tunisia has experienced an increasingly pronounced trade openness and has adopted a multitude of reforms to reinforce it through a large number of agreements with different foreign partners. However, this openness has gone simultaneously with an increase in regional inequalities wish have continued to grow, that is why we are interested in verifying, on one side, how this openness affects economic growth and, on the other one, whether it increases regional disparities within the country over the period (1990-2018). We start from the hypothesis that if trade openness manages to boost economic growth, its positive outcomes can have a contrasting effect at the regional level, benefiting some regions to the detriment of others. By crossing this double effect openness can accentuate territorial imbalances. We will use panel data econometrics to estimate our model. We will test the effect of openness on territorial disparities for the Tunisian case, especially between the 24 governorates where, there is no measure of regional inequalities yet, hence the interest of this study. Our econometric analysis clearly shows that the differences in endowments and characteristics at the level of the regions, such as differences in infrastructure or human capital, positively affect regional inequalities. Openness also appears to be a factor of positive influence, in particular by enhancing the polarization of economic activities and FDI within certain regions to the detriment of others.
Approach for Measuring a Ship to Shore Crane Actual Wheel Load
Authors: Starykov Maksym , Kokoshko Evgenii
Published: January 2023

Knowing the real crane deadweight, center of gravity (COG) and wheel loads instead of nominal ones is crucial for many reasons. One of the reasons relates to the checking the quay strength where the crane is going to be installed and it should be based on the crane maximum real wheel loads. Another example could be the crane transportation by sea on the deck of the vessel (Starykov & Van Hoorn, 2017). In this case predicting the precise value of the crane deadweight and its COG plays a key role in accurate calculation of the vessel stability, acceleration calculation from the ship motions and the vessel’s deck strength.
This paper demonstrates a new approach to finding the crane wheel load and in the result the deadweight and COG position. This method does not need special arrangement and uses combination of strain gauge measurements and Finite Element (FE) analysis only. The application of the method is demonstrated on example of the ship loader for which the possibility of capacity increase has been assessed.
Study on Stress of Malaysian Seafarers
Authors: Suhrab Mohammed Ismail Russtam , Kaliappan Teevaneshkumar
Published: January 2023

When working in the maritime industry, employees frequently face various stressors (or stress factors) connected to their many responsibilities on board the ship. The primary contributing causes of seafarers on ships are examined in this study. This study investigates the stressors such as physical, psychosocial, social, and high work demand factors to determine which stressors contribute the most to the seafarers on board the ship and identify stress levels between the deck and engine departments. This is done by collecting data on seafarers' stress based on a questionnaire prepared in the Likert scale method and analyzing the data using the SPSS method and the T-test method. In conclusion, in this study, a proper recommendation is given to the seafarers to manage and handle their work-related stress on board the ship as it affects the performance of the seafarers during their duties on the vessel. With the results of this research, proper recommendations can be proposed to reduce the stress based on the stressors that contribute the most to the seafarers to ensure a safe working environment is created on board the ship.
Oropharyngeal cancer diagnosis and treatment in actual clinical practice in the Republic of Bashkortostan: analysis for 2020
Authors: Musin Sh. I. , Sultanbaev A. V. , Menshikov K. V. , Zakirova L. K. , Mufazalov F. F. , Sharifgaliev I. A. , Nasretdinov A. F. , Osokin S. V. , Sharafutdinova N. A. , Ilyin V. V. , Lipatov D. O. , Sultanbaev M. V. , Timin T. E.
Published: January 2023

Introduction. Th e growing incidence of oropharyngeal cancer is driven by an increase in frequency of HPV-associated oropharyngeal cancer. Th e morbidity pattern of oropharyngeal cancer is area-specific.

Aim. To analyze the oropharyngeal cancer diagnosis and treatment in the Republic of Bashkortostan for 2020.

Materials and methods. Th e authors carried out a 2020 retrospective analysis of the diagnosis and treatment results of patients with oropharyngeal cancer. 79 patients were identified with this diagnosis. 84.8% (67/79) among them were males and 15.2% females (12/79). Th e mean age of the patients was 59.1 years. Th e site of primary tumor was on the oropharynx lateral wall in 37.8% cases (30/79), in the tongue root area — 24.1% (19/79), in the tonsils area — 17.7% (14/79), on the soft palate — 16.5% (13/79), on the oropharynx posterior wall — 3.8% (3/79).

Results. Examination of tumor morphological types revealed squamous cell carcinoma (SCC) with various degrees of differentiation in 92.4% cases (73/79), adenocarcinoma of minor salivary gland — in 6.3% (5/79) and sarcoma in 1.2% (1/79). 57.5% of 73 patients with SCC (42/73) underwent protein (p16) immunohistochemistry, while 42.5% of the patients (31/73) did not. According to a surrogate marker for HPV, the following results were obtained for 42 patients: p16-positive in 23.8% cases (10/42), p16-negative in 76.2% (32/42). Stage distribution according to TNM-7: stage I — 11.4% (9/79), stage II — 17.7% (14/79), stage III — 36.7% (29/79), stage IV — 46.8% (37/79). Stage distribution according to TNM-8 (patients who underwent p16 immunohistochemistry): stage I — 11.9% (5/42), stage II — 23.8% (10/42), stage III — 19% (8/42), stage IV — 45.2% (19/42). In 2020, 72% of patients (57/79) received definitive treatment, 10.1% (8/79) — palliative care, 15.2% (12/79) — supportive care, and 2.5% (2/79) refused medical treatment.

Discussion. Th e various types of radiation therapy were used as the main defi nitive treatment for patients with oropharyngeal cancer in 69.2% cases (45/65). Only 18.5% of patients (12/65) underwent surgery, 58.3% of which (7/12) received post-surgery radiation therapy.

Conclusion. 57.5% of patients (42/73) were detected with HPV status, 23.8% (10/42) revealed surrogate markers for HPV association. 69.2% of patients (45/65) received radiation therapy as the definitive treatment. 18.5% of patients (12/65) underwent surgery, 58.3% of which (7/12) received postsurgery radiation therapy.
Predicting optimal surgeon volume in patients with early gastric cancer
Authors: Dylenok A. A. , Rybachkov V. V. , Malashenko V. N. , Kashin S. V. , Shubin L. B. , Vasin A. B.
Published: January 2023

Introduction. The incidence of gastric cancer remains high, despite the increase in the share of stage I–II cancers — 37.1% in 2019. Surgical treatment remains relevant even in patients with “early” forms of gastric cancer (EGC). Therefore, the reliable means for determining the surgeon volume in such patients are to be urgently developed.

Aim. To estimate the probability of building a stable predictive model for patients with EGC in order to choose the proper surgical intervention.

Materials and methods. Th e research involved the data obtained from “Database of patients with gastric cancer, reflecting statistics of patients with a particular variant of surgical intervention, treated at Yaroslavl Regional Clinical Oncological Hospital during the period from 2009 to 2019”. All patients (n = 266) received different volume of surgery: intraluminal surgery (n = 128), wedge gastric resection (n = 36), classical gastrectomy or subtotal gastric resection (n = 102). According to the volume of intervention, the patients were ratified into several study groups. Statistical analysis involved case records of three groups of patients and was conducted using MedCalc Statistical Soft ware version 20.022 and Statistica 12.5.

Results. Ten factors were identified to form a patient model corresponding to each method of surgical treatment. Th e fairness of the division of patients into groups was checked by ROC-analysis in order to determine sensitivity and specificity of the set of criteria for the division. Th e following characteristics of the mathematical model were obtained by means of ROC analysis: concordance coefficient = 88.24%, AUC = 0.893; index J = 0.811; Se = 87.92; Sp = 89.04; +LR = 3.27; -LR = 1.31.

Conclusion. Introduction of this approach into clinical practice decreased the rate of gastrectomies and gastric resections by 15% for the last three years.