bluuebunny/crossref_metadata_2025 huggingface dataset:
ANÁLISIS DE LA EFICACIA DE LAS ESTRATEGIAS DEL MANUAL "ESTRÉS LABORAL EN PEQUEÑAS EMPRESAS: ABORDAJE PRÁCTICO PARA RIESGOS PSICOSOCIALES" EN LA DISMINUCIÓN DE LOS RIESGOS PSICOSOCIALES EN LA EMPRESA R. AUTOMOTRIZ
Authors: Quezada Jessica , González Oyarce Patricio
Published: February 2025

Objetivo: Evaluar la efectividad de las estrategias propuestas en el manual para reducir los riesgos psicosociales en el entorno laboral de esta empresa automotriz. Metodología: El enfoque del estudio fue cuantitativo y longitudinal. Se centró en la aplicación del cuestionario ISTAS21 versión breve para medir los riesgos psicosociales entre los empleados. Este instrumento permitió recopilar datos sobre aspectos como la carga de trabajo, la autonomía, y las relaciones interpersonales en el entorno laboral. Resultados: Los resultados mostraron cambios significativos en la percepción de los riesgos psicosociales. Antes de la intervención, el 66.7% de los trabajadores estaban en un "Nivel de riesgo medio" y el 33.3% en un "Nivel de riesgo bajo". Después de la intervención, estas cifras se invirtieron, sugiriendo una disminución del estrés laboral. En la dimensión de "Doble presencia", el riesgo alto se redujo del 66.7% al 33.3%, con un aumento del riesgo bajo del 0% al 66.7%. La dimensión "Apoyo social en la empresa" también mostró mejoras, pasando de un 66.7% de riesgo medio a un 33.3%, y de un 33.3% de riesgo bajo a un 66.7%. Estos resultados indican que las estrategias del manual fueron efectivas en mejorar el bienestar psicosocial de los empleados. Se recomienda un seguimiento continuo para asegurar la sostenibilidad de estos cambios y abordar futuras áreas de riesgo.
MARKETING DIGITAL COMO ESTRATÉGIA DE VENDAS: EM UMA EMPRESA DE CURITIBA – PR
Authors: Marinho Gerson Amaury , Coelho Tavany Cibele , Mendes Heloiza Pacheco
Published: February 2025

É nítido que o mercado vem passando por uma significativa transformação. E o marketing digital mudou a forma de trabalhar o marketing das empresas. Por isso, compreender as melhores estratégias de marketing digital para empresas locais se posicionarem na internet é de extrema importância. O objetivo deste artigo é apresentar a relação entre teoria e prática do marketing digital, bem como identificar por meio do estudo de caso as estratégias de marketing digital em uma empresa local de uniformes corporativos da cidade de Curitiba – PR. Foram utilizadas as metodologias: levantamento bibliográfico em livros, artigos acadêmicos e sites, além da pesquisa quantitativa e qualitativa e entrevista semi estruturada. Os resultados obtidos no estudo de caso demonstraram que os depoimentos de outros consumidores são capazes de influenciar na decisão de compra, e a ferramenta WhatsApp é considerada importante na comunicação com a empresa. Foi constatado através dos dados que as mídias utilizadas como fonte de pesquisa são em primeiro lugar o Google, seguidos por Instagram, WhatsApp e Facebook.
FORMAÇÃO DE PROFESSORES E A PRÁTICA NEUROPSICOPEDAGÓGICA FRENTE ÀS RELAÇÕES ÉTNICO-RACIAIS DE CRIANÇAS NEGRAS COM DEFICIÊNCIA
Authors: Gagliato Jéferson Felipe , Barbosa Edson Santos
Published: February 2025

O presente artigo é resultado do Trabalho de Conclusão de Curso de Especialização em Neuropsicopedagogia Escolar pela Faculdade Adventista da Bahia. A pesquisa que tem por objetivo compreender o processo de formação de professores da educação básica frente ao processo neuropsicopedagógico e as relações étnico-raciais de crianças negras com deficiência. Neste intuito, nossa principal intenção é conhecer e dialogar sobre as contribuições da Neuropsicopedagogia para o processo de formação inicial e continuada de professores que atuam como alunos duplamente estereotipados estigmatizados pelas questões sociais frente a deficiência, que por vezes impossibilita o seu desenvolvimento social e cognitivo. A metodologia que tornou possível a produção textual como resultado este trabalho caracteriza-se pela realização de revisão bibliográfica que emerge de uma pesquisa de natureza qualitativa. Portanto, o resultado desta pesquisa, colabora para o entendimento de que os professores da educação básica, ao se depararem com alunos negros e com necessidades educacionais especiais e/ou deficiências necessitam revisitar o habitar à docência munindo-se das colaborações das neurociências, em especial a Neuropsicopedagogia, mas se desvencilhando de quaisquer formas de discriminação. Além de perceber os indivíduos negros em sua totalidade e refletindo a importância de sua posição de agente modificador das realidades destes alunos que convivem com as interseccionalidades das deficiências e as questões étnico-raciais.
Dew Drops Over Skin: A Rare Case of Miliaria Crystallina in an Adult Female with Pemphigus Vulgaris
Authors: Gaikwad Prachi Sanjay , Palaskar Nachiket Madhukarrao , More Yuvraj Eknath , Gadkar Shubham Suraj
Published: February 2025

Miliaria crystallina occurs due to sweat duct obstruction and sweat retention into the stratum corneum. Miliaria is common in infants due to immaturity of eccrine glands. Heat, humidity, fever and a few drugs (e.g., isotretinoin and bethanechol) are known predisposing factors for the development of miliaria. To the best of our knowledge, miliaria has not been reported in patients with pemphigus vulgaris.
Neuro-cardiovascular correlates of controlled slow yogic breathing: A pilot study
Authors: Kharya Chhaya , Bhagat Om Lata , Deepak K. K.
Published: February 2025

Objectives:

We assessed the frontal cerebral hemodynamic alterations and neuro-cardiovascular interactions during alternate nostril breathing (ANB), a slow yogic breathing manoeuvre.

Material and Methods:

Five healthy male volunteers (age 30 ± 3.8 years) practised ANB for 5 min at five breaths per minute with the timing ratio (seconds) of 4:2:4:2 (inspiration: Pause: Expiration: Pause). We recorded 16 channels of functional near-infrared spectroscopy at the prefrontal cortex (PFC) region of the brain, electrocardiography, beat-to-beat arterial blood pressure (BP), respiratory movements and end-tidal carbon dioxide (ETCO2) for 5 min each: Pre (T0), during (T1) and post-ANB (T2). ETCO2, oxy-haemoglobin (oxy-Hb), deoxy-haemoglobin (deoxy-Hb), total haemoglobin (HbT) concentrations and time domain parameters of heart rate variability (HRV), BP variability (BPV) and baroreflex sensitivity (BRS) were calculated.

Results:

In comparison to T0, the oxy-Hb and time domain parameters of HRV and BPV at the left lower region of the PFC were significantly increased at T1. Up-BRS-SBP showed a trend of enhancement during the manoeuvre. A significant optically measured HbT concentration with a corresponding decrease in deoxy-Hb was observed at T1.

Conclusion:

Optically measured Oxy-Hb and HbT increased gradually with the increased practice of ANB, with a simultaneous decrease in deoxy-Hb suggesting a cerebral activation during ANB that may be predominantly in ventromedial PFC. Both baroreflex and mechanical mechanisms appear responsible for the improved neurovascular coupling. Slow yogic breathing may have beneficial effects in disorders that involve cerebral hypoactivation.
Advanced HIV Disease among Persons Newly Diagnosed with HIV: A Hospital-Based Study in Abia State, Nigeria
Authors: Ikpe George , Enukeme Juliet , Amuta Chukwuemeka , Nwakanma Ikenna , Agomoh Orieji , Chukwudinma Okwudili , Ukanwa Chioma , Nwaokenneya Peter
Published: February 2025

Background and Objective

Advanced HIV disease (AHD), defined by the World Health Organization (WHO) as a CD4 count of fewer than 200 cells/mm3 or WHO stage 3 or 4, remains a significant contributor to AIDS-related mortality despite global antiretroviral therapy (ART) scale-up. This study aimed to determine the prevalence and identify the determinants of AHD among newly diagnosed persons living with HIV in Abia State, Nigeria.

Methods

This was a retrospective chart review that analyzed data from patients newly enrolled in the United States centers for disease control and prevention (CDC) human immunodeficiency virus (HIV) ART program in Abia State between October 2021 and September 2023. Data were collected using a proforma designed to capture socio-demographic and clinical variables, including age, gender, residence, marital status, education level, and co-morbidities. Descriptive statistics was conducted to analyze the demographic and clinical characteristics of the participants, while logistic regression was conducted to assess the determinants of advanced HIV disease among ART-naive individuals newly diagnosed with HIV.

Results

The prevalence of AHD among the study population was 10.7%. The odds of AHD were significantly lower among individuals aged 26–35 years (aOR = 0.587) and 36–45 years (aOR = 0.638) compared to other age groups. Rural residence was associated with a lower prevalence of AHD (8.6%) compared to urban (13.9%) and semi-urban (12.2%) areas. Individuals with tertiary education (aOR = 0.625) and those employed (aOR = 0.503) showed significantly reduced odds of AHD. Persons identified through outreach testing were associated with a lower prevalence of AHD (2.9%) compared to outpatient department testing (40.2%).

Conclusion and Implications for Translation

The study supports targeted community testing to reduce AHD prevalence among persons living with HIV. Expanding outreach programs to urban areas and supporting individuals with lower socioeconomic status are critical. Addressing social determinants of health, particularly education and employment, alongside early ART initiation, can mitigate the progression to advanced disease.
Origin of ascending pharyngeal artery from cervical internal carotid artery: A case report of rare anatomical variation
Authors: Goyal Sumit , Sharma Rahul , Shirodkar Akshay Sainath , Chowdhary Vineet
Published: February 2025

Typically, the cervical segment of the internal carotid artery does not have any branches in the neck. However, there are many variations reported in the branching pattern of the common carotid artery in the neck with variations in the origin of the named branches of the external carotid artery either from the common or internal carotid artery. Knowledge about these possible variations is important while planning any vascular procedure in the neck. We report one such variation where the ascending pharyngeal artery was originating from the cervical segment of the internal carotid artery discovered in a patient who underwent digital subtraction angiography for stroke.
Representation of tri hita karana in megoak-goakan game and its implementation in physical education
Authors: Dartini Ni Putu Dwi Sucita , Sutajaya I Made , Suja I Wayan , Astawa Ida Bagus Made
Published: February 2025

Traditional games are activities that grow and develop in an area that is played from generation to generation are rich in cultural values that can be a means in the physical education learning process. This research aims to examine the values of Tri Hita Karana in megoak-goakan game and examine its implementation in physical education. The method used in this research is literature study by reviewing books, articles, journals, notes and reports related to the topic. The results showed that the megoak-goakan game represented the values of Tri Hita Karana, namely (1) harmonization with God (Parahyangan) in the form of religious rituals before starting the game, (2) harmonization with humans (Pawongan) in the form of cooperation, responsibility and mutual respect, and (3) harmonization with nature (Palemahan) in the form of maintaining cleanliness and preservation of the yard where to play. The megoak-goakan game can be implemented in physical education learning because it is proven to improve motor skills, physical fitness, develop social and emotional skills and pass on cultural values that are full of national character values.
The relationship between sports activity and the menstrual cycle of adolescent girls S-1 Midwifery Hafshawaty Zainul Hasan University
Authors: Hartanto Hartanto , Sary Yessy Nur Endah
Published: February 2025

Regular exercise for fitness is one of the best ways to reduce stress. Lack of sports activity can affect weak physical conditions and can cause stress, so this has an impact on mental health, emotional physiology in humans, especially women and the menstrual cycle in the reproductive system. The purpose of the study was to determine how much the relationship between sports activity and the menstrual cycle. This type of research is quantitative research. The sampling technique in this study used total sampling. The total sample was 37 midwifery S-1 students of Hafshawaty Zainul Hasan University Genggong level one 2024. The instruments used in this study are: (1) observation guideline sheet, questionnaire questionnaire. Data analysis techniques used in this study include: correlation coefficient test (r), hypothesis testing (test) t. The results of research on the relationship between sports activity and the menstrual cycle of adolescent girls obtained Person correlation data of 0.366; 0.03 <0.05. It can be concluded that the data from the Sports Activity scale with the Menstrual Cycle is normally distributed and a significant direct relationship and sports activity is one of the factors that influence the menstrual cycle. The conclusion in this study is that there is a significant relationship between sports activity and the menstrual cycle of adolescent girls S1 midwifery Hafshawaty Zainul Hasan University Genggong Probolingo.
NMR structure of chromeraxanthin - a unique allenic carotenoid of the apicomplexan alga Chromera velia
Authors: Takacs Zoltan , Hrouzek Pavel , Hájek Jan , Saurav Kumar , Pilny Jan , Brath Ulrika , Sobotka Roman
Published: February 2025

Chromera velia is photosynthetic alga that is evolutionary closest to the group of het- erotrophic apicomplexan parasites. The main light harvesting carotenoid of C. velia has been described as isofucoxanthin-like pigment, however its structure remained unknown. Here, we purified this pigment from a 5 L culture of C. velia using a two-step HPLC procedure and its structure determined using combination of tandem mass spectrometry and 2D- and 3D-NMR techniques. The data identified this pigment as a new allenic xanthophyll which we denoted chromeraxanthin. Although previously predicted to be structurally similar to isofucoxanthin, chromeraxanthin possess different arrangement of the terminal cycles and thus it likely not derived directly from fucoxanthin biosynthe- sis pathway. The six membered ring connected to the carotenoid backbone via allenic bond is identical to that of fucoxanthin including its O-acetylation. However, the second six-membered ring bearing epoxy group in fucoxanthin is replaced by a capsanthin-like cyclopentane ring in chromeraxanthin. Notably, similar structure lacking only the O- acetylation has been previously described as allenicmytiloxanthin isolated from Pacific oyster.
Directing an Elusive Photoredox [4+2] Cycloaddition Reaction in Water by Altering the Shape of Nano-confinement
Authors: Yadav Kishan K. , Tyagi Ritaj , Voora Vamsee K. , Dasgupta Jyotishman
Published: February 2025

Geometry of confinement and intermolecular packing of guest molecules inside supramolecular cavities can lead to product selectivity that is unattainable in bulk. Here we report for the first time an unprecedented radical-mediated intermolecular [4+2] photo-cycloaddition reaction of naphthyl acetylenes to form naphthyl-substituted phenanthrenes inside the confines of a cup-shaped water soluble nanocage. Using a combination of multidimensional NMR, FT-IR along with broadband femtosecond transient absorption spectroscopy, we characterize the reactive intermediates while providing mechanistic details of this unique host-guest charge transfer mediated photoreaction. Detailed electronic structure studies of the host-guest complex along with Deuterium-labelling experiments reveal that both the alkyne moieties are buried towards the smaller pore of the cup-shaped cavity, thereby driving a novel proximity-based [4+2] photo-cycloaddition product. Our results are in contrast to the typical oxidation via exposed solvent water or linear dimerization products observed in porous octahedral nanocage thereby highlighting the role of cavity shape and its confinement in driving product selectivity.
IMPACT ON THE LIVELIHOOD OF RURAL FARMERS DUE TO THE ADOPTION OF MODERN AGRICULTURAL TOOLS AND TECHNOLOGY IN NEPAL
Authors: . Binisha Paudel , . Sunil Regmi
Published: February 2025

Nepal mainly relies on agriculture for their livelihood, where 1/3 of the country’s GDP is generated from agriculture. Although agriculture is a major source of income for most Nepalese people, it is still lagging behind modern tools and technology. It is due to various reasons, such as high initial investment, poor knowledge, lack of awareness, small land holdings, subsistence farming, and ignorance of the government on the agriculture sector. One of the major reasons for low productivity is small and fragmented land holdings which cause obstacles and challenges to employing large machinery and modern technology as it is not desirable to fully exploit the resources, rather it will increase the cost of production. Employment of mechanization is mainly found in terai areas that are near the market and also found in the rural area that has connectivity to the roads. Mechanization helps to exploit the resources, land, labor, time, and energy resulting in increased agricultural production, productivity, profitability, and living standard of the farmers. Modern agriculture tools and technology include new varieties, irrigation pumps, drones, precision agriculture, climate-smart agriculture, Internet of Things (IoT), machinery (tractor), Animal-drawn implements (moldboard plow, disc harrow, disc plow), etc. The Extension system plays a crucial role in the adoption of modern agricultural tools and technology. It also acknowledges and aware the local people about the existence and use of various tools and technology and provides the training and skills to employ these tools at the local level. The government of Nepal also facilitates different projects and programs related to skill development and training toward the modernization of the agricultural system such as the Prime Minister Agriculture Modernization Program (PMAMP). The adoption of modern tools and technology enhances the productivity and living standards of rural farmers in several ways. It helps to maximize the efficiency of resource use, minimize waste and environmental effects, analyze the amount of nutrients in the soil, estimate crop water requirements, etc. Farmers are now able to monitor and identify their needs and problems themselves, optimize balanced doses of fertilization, track crop health and pest infestation, etc thus improving crop quality.
CONTENT AND FORMS OF ACTIVITY OF THE INSTITUTION OF THE PRESIDENCY IN ACHIEVING EUROPEAN INTEGRATION SUCCESSES
Authors: Shkuro Anton
Published: February 2025

The article examines the processes that have reinforced Ukraine's European integration trajectory, highlighting the pivotal role of the institution of the presidency as a central decision-making authorityfollowing the onset of Russia's open military aggression against Ukraine in 2022.

The author concludes that the Ukrainian response to the unjustified military actions of the Russian Federation did not result in panic and fear. Instead, it unified the nation in its efforts to strengthen and develop its state and political institutions that are tasked with making effective political decisions and providing the necessary conditions for the Ukrainian institution of presidency, particularly in matters of foreign policy.

The article examines the issue of Ukraine’s European and Euro-Atlantic integration;solution to whichwas significantly bolstered by the full-scale invasion of the Russian armed forces in 2022. These events generated a mobilization potential within Ukrainian society concerning foreign policy priorities. It is emphasized that Ukraine’s top political leadership promptly applied for EU membership shortly after the introduction of martial law. In June 2022, the European Commission published its conclusions, leading to all EU member states granting Ukraine the status of a candidate for EU membership.

The article analyzes the works of Ukrainian scholars who have studied the evolution of Ukraine’s European integration trajectory and the role of the institution of the presidency in this process. Special attention is given to the advancement of Ukraine’s Euro-Atlantic aspirations. The author positively notes that at the NATO Summit in Vilnius in 2023, the member states of the Alliance reaffirmed their commitment to Ukraine’s future accession to NATO. The article concludes that the communicative and political activities of the institution of the presidency have demonstrated to the international community the ability to make constructive proposals and secure positive decisions benefiting both Ukraine and its partners.
AUDIOMETRIC PROFILE AND CLINICAL CHARACTERISTICS OF HEARING IMPAIRMENT IN ADULTS AT NANGARHAR UNIVERSITY TEACHING HOSPITAL
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Rasouli Abdul , Azimee Mohammad , Azeem Fahima
Published: February 2025

Hearing loss (HL) is defined as a partial or total inability to perceive sounds in one or both ears, varying from mild to profound levels. This study aimed to determine the audiometric profile and clinical features of hearing loss among individuals who attended the Ear, Nose, and Throat Department at Nangarhar University Teaching Hospital (NUTH). This cross-sectional study involved 93 patients over a 15-month duration, from September 2023 to the end of November 2024. Adult patients aged 18 and older, presenting symptoms of hearing loss, were included in the study. Participants were divided into three age categories: 18-39 years (11.8%), 40-59 years (34.4%), and 60 years and older (53.8%). Males were 58.06%, and females were 41.93%. Individuals aged 60 and older showed the highest frequency of hearing loss, mostly with sensorineural hearing loss (40.86%), mixed hearing loss (8.60%), and conductive hearing loss (4.30%). Regarding laterality, 25.8% of patients had unilateral impairments, while 74.19% experienced bilateral hearing loss. Diabetes mellitus was present in 30.1% of the population, while hypertension affected 35.48%. Regarding the severity of hearing loss, 30.10% reported mild hearing loss (26-40 dB), whereas moderate hearing loss (41-55 dB) represented 32.25%. Profound hearing loss (91 dB or greater) was uncommon, occurring in 2.15% of cases. Tinnitus was reported by 37.63%, while vertigo was observed in 13.97%, predominantly among individuals with sensorineural hearing loss. The research revealed that hearing loss is prevalent among individuals over 60 years of age, primarily of sensory-neural origin, frequently associated with tinnitus and vertigo. Bilateral hearing loss was more prevalent than unilateral hearing loss, particularly in individuals with comorbidities such as diabetes and hypertension.
Enhancing mobility with advanced prosthetic ankle for lower limb amputees during bike riding and everyday activities
Authors: Mohanavalli M. , Kowshik A. , Keerthana S. , Vasudevan K. , Jeevanantham S.
Published: February 2025

Lower limb amputees encounter considerable challenges in executing fundamental daily tasks, especially in cycling. The lack of natural ankle mobility significantly hinders participation in physical activities that necessitate accurate foot positioning, like biking. This study proposes a groundbreaking system aimed at enhancing the functionality of ankle prosthetics specifically for cycling. This system incorporates cutting-edge technologies, including a gyroscope sensor and RF communication modules, which facilitate real-time, adaptive control of the prosthetic ankle's movements, emulating the natural foot motion required during biking. This system features an MPU6050 gyroscope sensor that monitors the motion of the leg, a servo motor that actuates the prosthetic ankle, and 433 MHz RF transmitter and receiver modules for wireless communication between the sensor and the motor. The gyroscope sensor captures instantaneous changes in the orientation of the residual limb, transmitting this data wirelessly to the servo motor, which adjusts the ankle's position, allowing for precise control over dorsiflexion (lifting the foot upwards) and plantar flexion (pointing the foot downwards), essential movements for cycling, walking, and other lower limb activities. Furthermore, a custom- designed 3D bio-printed prosthetic ankle encases the servo motor, ensuring a natural fit for the amputee while providing a lightweight and durable structure capable of enduring the demands of cycling. The servo motor integrated into the prosthetic ankle enables smooth and responsive movement, facilitating a more natural and fluid pedaling experience. This system not only restores functionality but also improves comfort and stability, thereby enhancing overall mobility and promoting inclusivity in recreational pursuits. This system significantly elevates their quality of life. Its modular architecture facilitates future modifications for various mobility needs.
Design of an adaptive portable oxygen concentrator with optimized battery efficiency and environmental sensitivity
Authors: Vasanth T. , Ramya R. , Mageswari T. , Charumathi C.
Published: February 2025

The COVID-19 pandemic, which first emerged in Wuhan province, China, in 2019, resulted in an unprecedented global demand for medical oxygen. In India, the need for oxygen surged dramatically in 2020 as COVID-19 cases escalated. To this sudden demand, various solutions were implemented, including the installation of oxygen generators in hospitals, the transportation of medical and industrial liquid oxygen, and the use of oxygen cylinders and concentrators. Unlike cylinders that require refilling, oxygen concentrators can provide a continuous supply of medical-grade oxygen, given that there is a reliable power source. They offer significant benefits for patients in the early stages of illness or following COVID-19 treatment, as they can be used in various locations. This paper aims to examine oxygen concentrators that utilize the Pressure Swing Adsorption (PSA) method for oxygen separation. Furthermore, this paper reviews developments in techniques for oxygen concentration to inform readers. This study seeks to enhance the availability of oxygen concentrators to meet local demand during emergencies.
Novel Methods of Personalized Treatment in Colorectal Cancer: A Literature Review
Authors: Khan Juwairia Farooque
Published: February 2025

Introduction: Colorectal cancer (CRC) is a leading global health concern, characterized by a high prevalence and significant mortality rate. Despite the progress in treatment modalities, there remains a critical gap in personalized therapy approaches, particularly in tailoring treatments to individual genetic and molecular profiles across different stages. This literature review aims to bridge this gap by analyzing recent advancements and emerging therapies, focusing on how they address the specific needs of patients at various stages of CRC. The aim is to provide insights into the efficacy of personalized treatments and identify areas requiring further research for optimal therapeutic strategies,
Methods: A systematic search of the PubMed database was conducted using keywords such as "metastatic CRC," "single cell analysis," "personalized treatments”, "single point mutation”, “solid cancer”, “genetic mutation” and “gene therapy” restricted to clinical trials published from 2017 to 2024. The search criteria included terms like "CRC" and "stage I, II, III, or IV" to identify relevant articles. This approach aimed to comprehensively review the current state of personalized therapies and identify gaps in knowledge that could inform future research. Research on colorectal cancer from 2017-2024 is crucial due to advancements in treatment, clinical guidelines, epidemiology, risk factors, diagnostic tools, and personalized medicine, providing comprehensive understanding,
Results: Recent studies show promising advancements in personalized treatments for CRC, particularly with targeted therapies and immunotherapy. Nanomedicine-based therapies and new agents improve drug delivery precision and efficacy. Immunotherapy, particularly for MSI-H tumors, shows effectiveness but remains variable based on genetic profiles. Combination therapies are emerging as a viable strategy.
Discussion: The findings highlight significant progress in personalized medicine for CRC, with targeted therapies and immunotherapy offering new hope. However, the complexity of CRC is highlighted by the variability in treatment responses across different genetic profiles. The review identifies a need for more comprehensive research to optimize these therapies and their long-term impacts.
Conclusion: Personalized treatments for CRC are advancing through targeted therapies, nanomedicine, and immunotherapy, but challenges persist in achieving consistent efficacy across diverse patient populations. Further research is needed to refine these approaches and improve outcomes.
Introducing Poesie scelte (2003-2021) by Edoardo Olmi: translation with commentary of ‘un anno e sedici mesi’, ‘poesia elbana’ and ‘Ulisse’
Authors: Sarti Evans Antonella
Published: February 2025

Poesie scelte (2003-2021) by Affluenti author Edoardo Olmi, published by Edizioni Ensemble, Florence, in September 2023, comprises some of the most crucial poems from three previously awarded collections: Il porcospino in pegaso (Premio Carver 2011), R:exist-stance (Premio Nabokov, 2017) and Stagioni scalene (Premio Il Delfino, 2021). Olmi’s poems are witty games challenging the structures of our language and psyche, while seeking free ways to create poetry – poetry meant in the ancient Greek etymology of poiesis, or else the ability to shape and inhabit new worlds through words. One of the main textual features of the collection is anarchy, especially expressed through layout and punctuation: the refusal of the capital letter after a full stop is inspired to the beat experiments, as the author pointed out, and to the ‘anarchic’ concept that no letter is more important than another.
Translating Indigenous literature from Aotearoa into Italian: Patricia Grace’s Pōtiki and Hone Tuwhare’s Small Holes in the Silence.
Authors: Sarti Evans Antonella
Published: February 2025

In this article, I aim to give some insight about translating into Italian two original bilingual works of literature from Aotearoa New Zealand, with te reo Māori as a crucial and enriching part of NZ English. I will focus on the iconic novel Pōtiki (1986) by Patricia Grace and on Hone Tuwhare’s celebrated poetry from Small Holes in the Silence (2016). In translating NZ literature, I have always been fascinated by new English words, puns and metaphors often entangled with Māori phrases, which clearly have no correspondence in the Italian language. As a translator, my intention is to echo the colours of words from the unique voices of Kiwi authors – the colours of words being conveyed through lexicon, syntax and rhythm. I believe that translating literature is a form of art: the constant choice of vocabulary and style means creative interpretation. On the other hand, in giving foreign readers access to original texts, the “invisibility of translation” ought to be retained1 . Invisibility is a kind of paradox: it depends on the translator’s skills to maintain this mediation imperceivable within that creative relationship. A good translation expresses the unique and diverse voice of the author, and surely, one of the most challenging tasks in literary translation is keeping faith to the original cultural context and registers through usage of contemporary, updated language. One example: Patricia Grace often used the word “race” in Pōtiki which was considered acceptable back in the 1980s but it was not longer recommended for use in 2017, when I translated the book; thus, I translated “one of our race” as “one of us” (“uno di noi”). Having Patricia Grace’s support and guidance throughout the translation of her work has been priceless and made me feel so honored. Also, I am thankful to Rob Tuwhare, for his kind assistance and enthusiasm during the translation of his father’s poems into Piccoli Buchi nel Silenzio (2018). I think it is dutiful, as a translator, to give a contribution to the diffusion of a wonderful, ancestral culture which is being continued, amplified and re-created in a written form by generations of authors – whose Resistance is inspiring. Finally, I will comment on the importance of translating Indigenous literature from Aotearoa into Italian, given the historical and cultural connections between those two countries and their people.
Learning Satisfaction And Social Support In Relation To Academic Achievement
Authors: Syahputra Andi , Basith Abd , Abidah Abidah , Ananda Liasya Putri , Wei Gao
Published: February 2025

Academic achievement has been a crucial aspect in for the students to have a successful learning process. It requires learning satisfaction and social support in every learning step. This research aims to: 1) describe the level of learning satisfaction, social support, and academic achievement; 2) analyze the differences in learning satisfaction, social support, and academic achievement, and; 3) analyze the influence of learning satisfaction and social support on academic achievement. This research uses quantitative methods with a survey approach. The population is 430 students of the English department at Islamic Colleges in Aceh. The simple random sampling technique functions to take the sample of 239 students (43 male and 196 female students). The instruments used in data collection are the Learning Satisfaction Scale, Social Support Scale, and Great Point Academic documentation. The data analysis uses descriptive statistics, MANOVA, correlation, and Multiple Linear Regression. The results show that the learning satisfaction, social support, and academic achievement levels are in the high category. University differences affect learning satisfaction, social support, and academic achievement levels. Finally, learning satisfaction and social support have a simultaneous impact on academic achievement.
Development Of An Arduino Iot System Solar Cell Electronic Practicum Guide Based On An Automatic Feed Thrower Prototype To Develop Students' Science Process Skills
Authors: Wardana Rendy Wikrama , Anggraini Yestilia , Firdaus M. Lutfi , Yanti Fitri April , Wibowo Firmanul Catur , Fitri Elsi Adelia
Published: February 2025

Science learning, especially in physics, is an abstract concept and difficult for students to understand. In addition, there is also a need for a bridge that can connect physics concepts with life in the student's daily environment. Therefore, technological innovations are needed in learning such as developing an electronic practicum guidebook for solar cells, Arduino IoT systems based on automatic feed thrower prototypes to develop students' science process skills. This study used a 4D model. The subjects of this study were 6th semester S1 Science students totaling 52 students. The data generation instrument uses questionnaires and implementation observation sheets. Data analysis techniques use qualitative and qualitative. Based on the results of the validation that has been carried out, the practicum guide that has been prepared as a whole has eligibility criteria that are very feasible to use, with a percentage of 92.25%, while the students' science process skills in the solar cell electronic practicum guide for the Arduino IoT system based on the prototype of this automatic feed thrower get an average of 92% with a very good category so that it can be considered that students are good at understanding and Work on the basis of practicum guidelines developed.
Trends of Physics Education Research on The Topic of Mechanics: A Bibliometric Analysis
Authors: Nurjanah Siti , Supahar Supahar , Sultan Jumriani , Fauzan Muhammad Ikhwan , Sajdah Siti Nurul , Seran D'aquinaldo Stefanus Fani , Mwakapemba James Leonard
Published: February 2025

This study aims to map the publication trends of international journal articles related to the topic of mechanics in physics education using bibliometric analysis of the Scopus database. Bibliometric analysis was conducted on the Scopus database with the help of the RStudio application with the biblioshiny package. We analyzed 196 relevant documents filtered with various settings that support the research objectives. The analysis showed a rapid increase in the number of publications on mechanics in physics education since the 2000s (102 articles recorded in 2012–2021), driven by the development of quantitative methods. Physics Education, Physics Teacher, and Revista Brasileira de Ensino de Fisica were the journals with the most contributions. Active author mapping identified Pendrill A-M, Fones SW, and Rieber LP as the most prolific, while citation and h-index analyses showed the work of Rieber LP, Rodrigues H, Adams DM, and Gauld C as the most influential. Geographically, the United States, Brazil, and China dominated publications, with limited international collaboration. This study provided a comprehensive profile of mechanical research trends in physics education to guide future development efforts.
Development of Digital Student Worksheet Based on Process Differentiation with STEM-PjBL Approach on Light Wave Material
Authors: Sekarningrum Miranti , Ellianawati Ellianawati , Subali Bambang , Linuwih Suharto , Nugultham Kulthida
Published: February 2025

The independent curriculum employs a differentiated approach to learning. The differentiation approach is employed to adjust the ability of students to comprehend the material. One model that can be applied is the PjBL model, which is integrated with STEM. Learners will engage in problem-solving activities in the context of physics education, utilizing technology as a tool. The integration of the model with the learning media employed is a harmonious process. Digital student worksheets represent a potential solution for the integration of the STEM-PjBL model. This research is a development research (RnD) project that employs the ADDIE development model. The development of digital student worksheets is comprised of three stages: analysis, design, and development. The analysis stage involves determining the characteristics of digital student worksheets. The design stage entails designing content for digital student worksheets. Finally, the development stage aims to obtain validation of feasibility and practicality from experts. The results of the validation of material and media experts indicate that digital student worksheet is suitable for use with revisions. The results of the practicality test of digital worksheets by teachers indicate that they are feasible, while the results of the test by students indicate that they are very feasible.
Development of the Physics Knowledge Enrichment Book “Lightning” to Improve High School Students’ Science Literacy and Environmental Literacy
Authors: Febriya Dhea , Desnita Desnita , Ratnawulan Ratnawulan
Published: February 2025

The independent curriculum emphasizes literacy skills as the most important learning objectives. The two literacies that are greatly needed in the 21st century are science literacy and environmental literacy. However, these two literacies among high school students in Indonesia are still relatively low. The subject that is able to achieve both literacies in an integrated manner is physics. The purpose of this development research is to produce a physics knowledge enrichment book "lightning" to improve science literacy and environmental literacy of high school students that is valid and practical. This type of research is research and development (R&D) with the ADDIE model. The subjects of the study were physics teachers and grade XI high school students. Data were collected through questionnaires. Data analysis techniques include calculating the average score and Aiken validity index. The results of the study showed that: 1) The enrichment book was stated in the valid category in terms of material, language, presentation, and graphics; 2) The enrichment book by teachers and students was stated in the practical category in terms of ease of use, learning effectiveness, and benefits. Therefore, the physics knowledge enrichment book "lightning" that was developed is valid and practical as a solution to improve science literacy and environmental literacy of high school students.
Profile of Scientific Creativity Based on Project Based Learning of Physics Education Undergraduate Students: Preliminary research
Authors: Sumo Maimon , Jatmiko Budi , Supardi Zainul Arifin Imam
Published: February 2025

This research aims to describe the profile of scientific creativity abilities of undergraduate students in the basic physics 1 course through the application of the Project-based Learning model. The sample in this research was 50 undergraduate physics education students at Madura Islamic University taking introductory physics courses. The data obtained was analyzed quantitatively and then described. The students' scientific creativity profile was obtained by administering a scientific creativity test and a student response questionnaire using the implementation of Project Based Learning. The data was analyzed using a score calculation formula, the results were categorized into very high, high, medium and low category. After obtaining the scoring, the data is interpreted in percentage form. Meanwhile, student response questionnaire were measured using Likert scale and then interpreted in percentage form. The research results showed that 83% of students' scientific creativity was still classified as low, while 17% of students' scientific creativity was classified as moderate. With details of the creative personal character profile for each indicator of scientific creativity as follows: 1) Scientific Phenomena 52.5%, 2) Scientific Knowledge 15%, 3) Scientific Problem solving 13.75%, 4) Creative thinking ability 20.4%, 5) advanced scientific product design 12.7 %, and 6) Technical product 8.7%. The results of the student response questionnaire showed that the majority of students experienced difficulty in write their initial knowledge about physics, difficulty in solving problems and answering questions based on the scientific phenomena presented.
Tracking Antimicrobial Resistance in Bovine Fecal Material across Farms in Lebanon: Sequencing and Genomic Surveillance Using a Comprehensive One Health Approach
Authors:   ,   Lebanese American University -- Chouran Beirut, Tannous Jame
Published: February 2025

Antimicrobial resistance (AMR) poses a worldwide threat to both human and animal health. The rapid spread of extended-spectrum β-lactamase (ESBL)-producing, and carbapenem-resistant Gram-negative bacteria stance a serious challenge, especially in Lebanon, where limited surveillance programs are implemented, and antibiotics are often inappropriately consumed. Animal fecal material is an important reservoir of resistance genes and mobile elements. This study aims to address AMR through an integrated One Health approach. 62 ESBL-producing bacteria were isolated from fecal material collected from healthy and diseased cows. Whole-genome sequencing revealed the prevalence of multi-drug resistant Gram-negative bacteria, with Escherichia coli being the most common. Resistance to amoxicillin (59/62), ceftriaxone (45/62), and cefotaxime (45/62) were common in the recovered isolates, with some being additionally resistant to imipenem (6/62), meropenem (4/62), and ertapenem (4/60). Resistance to β-lactam was mainly linked to blaCTX-M-15 and blaTEM-1B, while plasmid typing revealed 22 replicons, the most common being IncFIB and IncFII. Notably, colistin resistance was detected in one of the recovered E. coli, and upon further characterization, it was linked to mcr-1.1 on an IncHI2A/IncF multi-replicon plasmid. The findings of this study revealed the presence of highly resistant Gram-negative bacteria, including strains with plasmid-mediated resistance to critical antibiotics such as colistin, emphasizing the risks posed to both human and livestock health. Implementing comprehensive surveillance systems, and promoting responsible antibiotic use are essential steps to mitigate the spread of AMR. These efforts must be guided by an integrated One Health approach to effectively tackle the interconnected challenges of AMR across human, animal, and environmental health sectors.
Priming bumble bees with caffeine, odour of the target crop, and a food reward, has minimal effects on fruit crop pollination and yield in a semi-commercial setup
Authors: Arnold Sarah , Silva Celine , Dudenhöffer Jan-Hendrik , Hall David , Farman Dudley , Wäckers Felix , Stevenson Philip , Fountain Michelle
Published: February 2025

Caffeine is a widely occurring plant defence chemical that occurs in the nectar of some plants, e.g. Coffea or Citrus spp., where it may influence pollinator behaviour to enhance pollination. Previous laboratory work found inexperienced bumblebees (Bombus terrestris) located new food sources emitting a learned floral odour more consistently if they had been fed caffeine in association with the odour and a food reward. Inexperienced bees primed with caffeine also made more initial visits to target robotic flowers emitting the target odour, compared to control bees or those primed with odour alone.
We tested whether these behaviours could be replicated under semi-field conditions in strawberry crops, to improve crop pollination and hence marketable yield. In three trials in mini-polytunnels, odour/caffeine-primed and control bumblebee colonies were allowed to forage on strawberry crops with nectar-rich distractor flowers present. Some small effects of caffeine priming were observed (a slight increase in the proportion of visits to the target flowers in one trial), but after controlling for polytunnel identity, the priming treatment did not influence crop yield and quality. While caffeine priming of commercial bumblebee colonies may have potential to improve pollination in crops, further research is needed to optimise the system for in-field use.
Global Trends in Contributing Factors to Mathematics Performance in Secondary Schools: Lessons for South Africa 2015 – 2024
Authors: Theron Hendri
Published: February 2025

This review of the literature examines global trends related to factors contributing to mathematics performance in secondary schools from 2015 to 2024, to draw lessons for South Africa. The study identifies key issues in South African mathematics education, such as insufficiently trained teachers, inadequate facilities, and lack of resources. It contrasts these factors with those of high-performing countries such as Singapore, China, Taipei, and Korea, which consistently excel in international assessments such as the TIMSS (Trends in International Mathematics and Science Study). The theoretical framework is grounded in complexity and chaos theory, emphasising the non-linear and dynamic nature of educational systems. The butterfly effect and chaos theory are used metaphorically to illustrate how small changes in initial conditions can lead to significant long-term impacts. Methodologically, the review employs a thematic analysis of literature sourced primarily from the Scopus database, covering a decade of research. After the initial selection procedure, 24 relevant articles were selected according to the predetermined selection criteria. The findings highlight the critical role of teachers, including their qualifications, professional development, and the establishment of a growth mindset. Furthermore, the importance of teaching and learning support, teacher-student relationships, resources, learning environment, and socioeconomic status is underlined. The review concludes that South Africa can improve its mathematics performance by ensuring that all mathematics teachers are well-qualified, providing adequate resources, and fostering a conducive learning environment. The study also recommends further research into early childhood development and a broader database search to enhance the understanding of factors influencing mathematics performance.