bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Penulisan Kajian Pustaka Artikel Jurnal Ilmiah Berbahasa Inggris Bagi Guru Sekolah Menengah di Kota Lahat Sumatera Selatan
Authors: Safnil Safnil , Syahrial Syahrial , Azwandi Azwandi
Published: May 2022

Menulis kajian pustaka untuk artikel jurnal berbahasa Inggris merupakan tugas yang cukup sulit termasuk bagi guru bahasa Inggris, karena membutuhkan pengetahuan tentang Move dan Step dan keterampilan menulis yang benar dan efisien dalam bahasa Inggris. Tujuan pelatihan ini adalah untuk mengajar dan membimbing guru bahasa Inggris di Kota Lahat Sumatera Selatan dalam menulis kajian pustaka untuk artikel jurnal berbahasa Inggris. Pelatihan diikuti oleh 21 orang guru bahasa Inggris yang dilakukan secara tatap muka dan virtual. Sebelum dan setelah pelatihan, guru bahasa Inggris tersebut diminta untuk mengisi angket yang telah disiapkan. Hasil pelatihan dan pendampingan menunjukkan bahwa sebagain guru merasa menulis kajian pustaka susah dan sebagian lagi tidak namun sebagian besar mereka bersikap positif terhadap menulis artikel untuk jurnal internasional dalam bahasa Inggris. Setelah pelatihan sebagian besar peserta pelatihan meraka bahwa metode pelatihan yang digunakan efektif, pengetahuan dan keterampilan mereka dalam menulis kajian pustaka semangkin baik dan motivasi mereka dalam menulis artikel semangkin tinggi. Sebaiknya pelatihan menulis karya ilmiah seperti artikel jurnal semangkin sering dilakukan untuk guru bahasa Inggris dengan bekerjasama dengan perguruan tinggi terdekat agar mereka makin mahir daam menuis karya ilmiah.
Pelatihan dan Pendampingan Pembuatan Big Book Pada Guru Sekolah Dasar di Kota Metro
Authors: Octaviani Srikandi , Sufianti Alif Via , Azizah Hanifah Fitria , Hapsari Winie Setia Prilapnita , Maharani Winda
Published: May 2022

Tujuan dari kegiatan pelatihan dan pendampingan ini adalah menghasilkan media pembelajaran yang mudah dibuat, praktis, yang sesuai dengan tujuan capaian pembelajaran, sesuai dengan karakteristik dan perkembangan kognitif peserta didik, dan peserta mampu memahami konsep, tata cara membuat serta mampu mengimplementasikan Big Book pada proses kegiatan belajar di kelas. Dalam pelaksanaan kegiatan ini menerapkan beberapa metode diantaranya adalah In house Training, ceramah dan mentoring. Adapun hasil dari pelatihan dan pendampingan ini melatih keterampilan peserta dalam merancang dan membuat sendiri media pembelajaran Big Book yang sesuai dengan karakteristik dan perkembangan kognitif peserta didiknya, menghasilkan Big book yang sesuai dengan tujuan capaian pembelajaran, serta mampu mengimplementasikan Big Book pada proses kegiatan belajar di kelas. Adapun kesimpulan dari kegiatan ini adalah pentingnya membuat media pembelajaran sendiri yang dapat disesuaikan dengan capaian tujuan pembelajaran dan karakteristik peserta didik, sehingga pembelajaran yang dilakukan akan lebih bermakna.
Pelatihan Bertutur (Storytelling) Destinasi Wisata bagi Pemangku Kepentingan di Kawasan Objek Wisata Budaya Ciung Wanara Karangkamulyan Menggunakan Asistensi Whatsapp Group
Authors: Rohayati Dedeh , Iskhak Iskhak , Rustandi Andi
Published: May 2022

Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan sumber daya para pemangku kepentingan di kawasan obek wisata budaya Ciung Wanara Desa Karangkamulyan Kecamatan Cijeungjing Kabupaten Ciamis melalui pelatihan keterampilan bertutur (storytelling) destinasi wisata menggunakan asistensi Whatapps Group.  Khalayak sasaran adalah para pemangku kepentingan yang terdiri dari perwakilan perangkat desa, pengurus harian Paguyuban Kawargian Adat, pengurus harian Bumdes, Juru Pelihara, pemandu, pedagang kios, pedagang kaki lima, pedagang asongan, petugas parkir, pengurus harian Karang Taruna, dan pengurus Museum Ciung Wanara. Pengumpulan data dilakukan dengan observasi dan interview mendalam menggunakan teknik Diskusi Kelompok Terfokus (Focus Group Discussion). Observasi dilakukan untuk mengamati lebih jauh dan secara langsung kemampuan menyusun cerita untuk menuturkan (storytelling) destinasi wisata budaya Ciung Wanara Karangkamulyan. Hasil observasi baik secara offline dan online berupa tangkap layar, panggilan suara dan pesan suara Whatsapp Group kemudian dianalisa secara detail melalui beberapa tahapan: reduksi data, penyajian menggunakan tabel, reduksi data, tampilan data, dan penarikan kesimpulan. Sedangkan hasil Diskusi Kelompok Terfokus (Focus Group Discussion) dianalisa secara tematik dengan beberapa tahapan terlebih dahulu seperti transcribing, coding, categorizing, dan interpreting. Hasil pengabdian kepada masyarakat ini menunjukkan bahwa WhatsApp Group telah menjadi solusi dan media yang memudahkan pemangku kepentingan dalam penguasaan tekhnik bertutur (storytelling) destinasi wisata budaya Ciung Wanara. Keberhasilan peserta pelatihan mencapai 64% dalam memahami materi yang telah disampaikan. Selain itu, asistensi yang diperoleh pemangku kepentingan di kawasan wisata ini adalah pemahaman terhadap materi bertutur (storytelling) termasuk definisi bertutur (storytelling), unsur-unsur bertutur dan pemahaman menyajikan storytelling masing-masing mencapai 55%, sedangkan materi mengenai keunggulan bertutur (storytelling) mencapai 46%.
Safety and Efficacy of Bone Cement (Spinofill®) for Vertebroplasty in Patients with Osteoporotic Compression Fracture : A Preliminary Prospective Study
Authors: Park Han Byeol , Son Seong , Jung Jong Myung , Lee Sang Gu , Yoo Byung Rhae
Published: May 2022

Objective : Although several commercialized bone cements are used during percutaneous vertebroplasty (PVP) for patients with osteoporotic vertebral compression fracture (OVCF), there are no reports using domestic products from South Korea. In this study, we investigated the safety and efficacy of Spinofill® (Injecta Inc., Gunpo, Korea), a new polymethyl methacrylate product.Methods : A prospective, single-center, and single-arm clinical trial of 30 participants who underwent PVP using Spinofill® for painful thoracolumbar OVCF was performed with 6-months follow-up. Clinical and surgical outcomes included the Visual analog scale (VAS), Korean-Oswestry disability index (K-ODI), and Odom’s criteria, complication rate, and recurrence rate. Radiological outcomes were evaluated by measuring the findings of postoperative computed tomography and simple radiograph.Results : The pain of VAS (from 8.95±1.05 to 4.65±2.06, p<0.001) and the life quality based on K-ODI (from 33.95±5.84 to 25.65±4.79, p<0.001) improved significantly, and successful patient satisfaction were achieved in 20 patients (66.7%) 1 day after surgery. These immediate improvements were maintained or more improved during the follow-up. There was no surgery- or product-related complications, but OVCF recurred in two patients (6.7%). Favorable cement interdigitation was reported in 24 patients (80.0%), and extra-vertebral cement leakage was reported in 13 patients (43.0%). The mean vertebral height ratio (from 60.49%±21.97% to 80.07%±13.16%, p<0.001) and segmental kyphotic angle (from 11.46°±8.50° to 7.79°±6.08°, p=0.002) improved one day after surgery. However, these short-term radiological findings somewhat regressed at the end.Conclusion : The overall outcomes of PVP using Spinofill® were as favorable as those of other conventionally used products.
The effect of combaine administration of L-arginine and omega-3 polyunsaturated fatty acids on the spectrum of free amino acids and biogen amines in hyppocampus of rats undergoing subtotal cerebral ischemia
Authors: Razvodovsky YE, , Smirnov VY, , Doroshenko EM , Bon EI , Korotkevich TV , Maksimovich NYe , Semenenia IN
Published: May 2022

The aim of this study was to estimate the changes in the pool of free amino acids and their derivatives in hippocampus of rats undergoing subtotal cerebral ischemia (SCI) and treated with L-arginine and omega-3 polyunsaturated fatty acids (PUFA). Experiment was held on 18 rats: 12 animals were undergoing bilateral filament occlusion of arteries carotid, 6 of them L-arginine and omega-3 PUFA was administrated. The drug omega-3 PUFA "Omegamed" (at a dose of 5 g/kg of body weight) was injected intragastrically during the week preceding the simulation of SIMG. L-arginine (at a dose of 100 mg/kg body weight) was injected intravenously just before ligation of the common carotid arteries. The analyses of free amino acids and their derivates levels in the blood plasma extracts were carried out by reversed phase HPLC. In the hippocampus of rats with SIGM, there was an increase in the levels of histidine, 3-methylhistidine, glutamine, α--aminobutyrate, isoleucine, leucine, valine, as well as a decrease in the levels of threonine, tyrosine, and α--aminoadipic acid. Administration of L-arginine and omega-3 PUFAs prevented ischemia-induced disruption of threonine, histidine, glutamine, α--aminobutyrate, α--aminoadipic acid levels, and also had a corrective effect on the serotonin system of the hippocampus.
Revisiting two clinical techniques for diagnosing myasthenia gravis in Covid times: Pointing to semiology
Authors: Vargas-Cañas Alberto , Martínez Alejandro , Velásquez Mauricio , Guerrero Rodrigo
Published: May 2022

As it has been evident in these times of the Covid-19 pandemic, the majority of health resources have been focused to the acute treatment, vaccination or research to this condition. By these reasons, some confirmatory complementary tests in many pathologies cannot be made or are postponed, including Myasthenia Gravis. Two clinical neurological signs useful for diagnosis of Myasthenia Gravis are revised: the “Curtain Sign” (also called paradoxical ptosis), that is evoked opening the more closed eye, which results in a dropping of the contralateral eyelid; and the Mary-Walker maneuver, which results from repetitive pronation-supination exercise under anaerobic conditions in one or both arms resulting in increasing of bilateral ptosis. The importance of a presumptive early diagnosis of Myasthenia Gravis is the early onset of specific treatment even when it’s impossible to carry out complementary studies like single-fiber electromyography, thoracic images, or specific immune studies. .
“How learning doesn't work” Children evaluate their cell phone use – An empirical pilot study
Authors: Supper Angelika , Teuchert-Noodt Gertraud
Published: May 2022

In our increasingly digitally organized society, we enjoy great benefits from easier working conditions and the acceleration of developmental processes. Children are expected to be prepared for this and to receive a tablet or cell phone as early as possible. This, however, poses a huge risk because a child’s brain must initially organize itself in an analog fashion. This means that the spatial-modular building of neural networks and the rhythmic timing of brain activities mature very slowly through upbringing and school education to support memory formation and thinking. Once this foundation has been established, a digital workplace will be easily accessible to any young adult. To investigate in more detail the impacts of private cell phone use on the learning abilities of children, we designed a cognitive test that, among other things, measures spatiotemporal abilities and memory performance. A total of 54 third-grade students (aged 8 and 9) were subjected to the testing at an elementary school in the Rhein-Neckar-Kreis/Baden Württemberg region from December 2019 to March 2020. The intensity of private cell phone use was measured with a nonverbal method, the evidence-based water glass method. Prior to testing, we evaluated the children’s ability to evaluate themselves with this nonverbal method and designed a lie item, which allowed us to filter out those children who were unable to evaluate themselves. Due to the high data quality, variance analysis was used to analyze the quantified data statistically. The results showed that prefrontal cortex skills such as spatial perception, concentration, and anticipation were significantly poorer in third-graders with heavy cell phone use compared to those with little or no cell phone use. The heavier the cell phone use, the less well developed was their cognitive memory performance if it included a time delay. Furthermore, we observed a significant impact of the intensity of cell phone use on the motivation to go to school. The frequency of sports activities, playing outdoors, friendships, and homework was not significantly affected by cell phone use. The reason for this could be that modern schoolchildren only have rather limited control over the timing of these activities. Overall, the data suggest that other cognitive and emotional-motivational abilities such as spelling and handwriting are also adversely affected by heavy cell phone use. This could be verified by an investigation with a larger sample size. The findings of this pilot study should be a warning: with the digital transformation, our society could cause severe and also irreversible cognitive damage to the young generation. The discussion shows that brain research findings from the past half century provide comprehensive evidence for this
Gamma Knife® radiosurgery for trigeminal neuralgia
Authors: Lyons Alexandra , Pinkham Mark , Foote Matthew , Olson Sarah , Foley Heath , Hall Bruce
Published: May 2022

Background: Trigeminal neuralgia (TN) affects up to 0.3% of the population with pain often difficult to manage. It commonly affects patients over 50 years, and occurs more frequently in women. Treatment options include medical therapy, surgery (microvascular decompression (MVD) and percutaneous balloon compression (PBC)) and Gamma Knife® radiosurgery (GKRS). GKRS has been available at the Princess Alexandra Hospital since October 2015. Our objective was to evaluate the efficacy of GKRS on patients with TN and investigate the impact of known prognostic variables on patient outcomes. Method: A retrospective review was conducted on all patients who received GKRS for TN from October 2015 till March 2018 in a single center tertiary neurosurgical referral hospital. Results: 43 patients with TN were treated with GKRS with a median follow up time after treatment of 7 months (6 weeks - 36 months). Median age was 69 years, 51% were female and 21% had atypical symptoms. 33% previously had surgery (7=MVD, 7=PBC). Clinical benefit after GKRS was observed in 79% of patients at 1 month, 73% at 3 months, 74% at 6 months and 87% at 1 year. Of the 49% who experienced a relapse of pain within 1 year post GKRS, the median time to relapse was 8 weeks. No serious adverse events or severe toxicity were recorded. Patient and treatment factors that predicted worse outcomes were the presence of a vessel contacting the nerve, female gender and a higher radiation dose. Conclusion: GKRS is an effective treatment option for patients with TN and it is particularly useful to consider in those with co-morbidities that make surgery high risk. GKRS has acceptable short-term beneficial results in TN, however with relapse other treatment options may be required.
Measurements, mechanisms and potential therapy for preventing chemotherapy-induced cognitive impairment
Authors: Yin Jie , Han Yuan-Yuan , Shi Dong-Dong
Published: May 2022

Cognitive impairment following chemotherapy, also called chemobrain, is reducing the life quality of millions of cancer patients. It is urgent to discover therapeutic methods against chemobrain. In fact, neither measurements nor mechanisms are yet to be defined. To discover efficient treatment on chemobrain, in this review, we firstly focus on applications of objective and accurate methods to study the measurement of chemobrain, such as Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). Furthermore, we highlight the potential mechanism of chemobrain including neuroinflammation, cell apoptosis and synaptic degeneration. Chemotherapy can induce neuroinflammation and cell apoptosis in brain. Synaptic plasticity also decreased in chemo-agent treated mice. Based on other cognitive impairment diseased, we also engaged in looking for effective treatment on cognitive impairment after chemotherapy in cancer patients. Synaptic repair, stem cell transplantation, Chinese medicine and psychological rehabilitation are all powerful candidates for treating chemobrain.
A Case Report on a Patient With Unrecovered Bell’s Palsy of 2 Years Duration Treated With Non-Interventional Pulsed Radio Frequency Electrical Current
Authors: Phyllis Berger
Published: May 2022

Patents with unrecovered Bell’s palsy or a mono facial paresis from other conditions that affect the facial nerve as in Ramsey Hunt disorder, iatrogenicity or disease, often find that their condition causes long term paresis in the facial muscles with functional, psychological and social impacts upon their lives. Previous treatments to the local inflammation occurring in the facial nerve as it exits the stylomastoid foramen with ultrasound, non-stimulating electrical currents and electrical functional muscle stimulation of the compromised facial muscles, often do not restore full function to the affected side of the face. A non-interventional pulsed radio frequency (NI-PRF) electrical current has been observed to stimulate the facial nerve with fasciculations occurring in the main branch of the VII th nerve and its concomitant branches to the upper, middle and lower areas of the face resulting in improved motor function. This commences immediately within the first treatment in acute Bell’s Palsy and only 4-6 treatments are required to assist most patients. Prolonged conditions that were previously thought unrecoverable (after years) have restored motor control and this usually occurs between 1 – 3 months of treatment. Treatment requisite does not have to be continuous and can be given twice weekly or even once weekly over the period mentioned above. Even if treatment is interrupted the condition continues to improve. This would have both an economic and efficient time saving impact on these patients. The main case history of an unrecovered Bell’s palsy of 2 years duration is discussed in this report and demonstrates marked improvement after only six treatments. Electroacupuncture is often included in the above treatments as an adjunct to increase circulation and improve muscle activity
The new method of assessing EEG synchrony is the best instrument for identifying interindividual and intergroup differences
Authors: Pavlovich Kulaichev Alexey
Published: May 2022

The principal errors of spectral and coherent analysis are discussed, and the mathematics of these methods is not related to EEG nature. In this regard, in 2011, the new method was developed for evaluating EEG synchrony by the correlation of envelopes, which has a direct and fundamental physiological meaning. The basics of this method and the methodology of subsequent multilateral statistical analysis are considered. The effective use of the method for identifying individual and intergroup differences in the norm and several types of schizophrenia, depressive diseases, five stages of sleep, and similar functional states are presented
Music therapy for patients with alzheimer’s disease: A focused critical review
Authors: Fountouki Antigoni , Kotrotsiou Stiliani , Paralikas Theodosios , Theofanidis Dimitrios
Published: May 2022

Introduction: Dementia is one of the most pressing issues in old age, affecting not only the person who suffers it but also the caregivers and family. Aim: The purpose of this systematic review is to explore the therapeutic value of music as a nonpharmacological intervention for people with AD. A secondary objective is to reveal evidence on the type of music that is most beneficial. Methods: The systematic search included critical review of different databases: Google Scholar, Science Direct, PubMed, Scielo, Dialnet and Cochrane. The search dates ranged from 2006 to 2019 and individual and combinations of the following keywords were used: “Alzheimer’s disease”, “music”, “music therapy” and “dementia” in English, Spanish and Greek. The selected papers were then read in their entirety and further exclusions were made based on ‘fine-tuning’ according to the inclusion and exclusion criteria. Results: Results revealed publications from many different countries such as: Spain, Greece, USA, Netherlands, Brazil, Germany and China. Searching the databases led to the selection of 21 research studies and 7 systematic reviews including a Cochrane review. Discussion: MT has elicited considerable interest amongst researchers and findings clearly illustrate that this innovative and non-invasive method is of great protective advantage to those suffering cognitive decline as found in AD and that responses to MT are evident within a short period of time [within 5 weeks] with as few as one to two half hour sessions per week. Conclusions: MT stimulates cognitive function, improves mood, and reduces behaviour problems triggered by stressful conditions. It is an inexpensive and pleasant intervention with no adverse effects and has emerged as a promising additional therapeutic approach for patients with dementia. It seems that most benefit is achieved when familiar music is enjoyed amongst a group adding a social element to the whole experience.
Viral Infection in Athletes
Authors: Deligiannis Asterios
Published: May 2022

Most epidemiological and clinical studies suggest that systematic physical activity increases the body's immune capacity against infections. On the contrary, much evidence suggests that prolonged vigorous exercise training favors the development of infections, particularly viral ones. This twoway exercise effect is described as a “paradox” of exercise. Some theories have been developed about these adverse effects of exhaustive exercise on cellular and humoral immunity, such as open window theory, the J-curve, and the S-curve. However, some questions remain regarding the prevalence of these mechanisms, and the level of the exercise that leads to immunosuppression. Other factors favoring the onset of viral infections in athletes are stress, climatic conditions, incorrect nutrition, crowding, etc. The most common infections are viral infections of the upper respiratory tract, influenza, infection from the Epstein Barr virus. There is no information available to correlate the volume of physical stress with COVID-19 infection. The best preventive measures are to avoid exercising during a febrile infection, vaccination, adequate nutrition, and reduce stress..
Usefulness of colchicine for Covid-19 myopericarditis in athletes. A case report and review of the literature
Authors: Deligiannis Asterios , Dervisopoulou Efthymia , Kouidi Evangelia
Published: May 2022

Cardiac injuries, specifically acute myocarditis, are a common complication of COVID-19. Recent studies in the literature have supported the beneficial and safe results of colchicine administration in the general population in cases of COVID-19 infection, especially in cases of myocardial injuries. However, the frequency of occurrence in athletes, its treatment, and management of these individuals concerning the return to competitive sports have not yet been clarified. The present case description is a novelty in that it refers to the onset of a mild form of acute myopericarditis secondary to COVID-19 infection in an athlete that was successfully treated as an outpatient with only colchicine. A 45-year-old marathon runner with no underlying health problems showed clinical symptoms of acute pericarditis and mild febrile infection. The biochemical tests were characterized by an increase in the level of troponin. MRI established the diagnosis of mild myopericarditis. In addition, he has been tested positive for COVID-19 by molecular/PCR test. The patient was treated with colchicine alone for three months. After that time, all the clinical and laboratory findings of myopericarditis were subsided. Six months after the onset of the disease, the athlete returned to full competitive action.
Preliminary Step towards COVID-19 Inactivated Vaccine Development in Egypt
Authors: Saad, Mohamed A , Saleh Amani A , Ryan Islam , Amin Magdy , Saleh Mahmoud S , Abdulaal Tayseer , Hassan Wael A , Samir Mahmoud , Raouf Ahmed A , Khattab, Ayman A , Fahmy Nermeen T , Shindy Mohamed I , Abdelgayed Sherein S , Seadawy Mohamed G , Zekri, Abdel-Rahman N , Fahmy, Hossam M , Amer Khaled
Published: May 2022

The current worldwide COVID-19 pandemic is causing severe human health problems, with high mortality rates and huge economic burdens requiring the urgent development of a safe and effective vaccine. Here, preclinical evaluation of an inactivated SARS-CoV-2 vaccine candidate (EgySerVac-20) is reported. Oropharyngeal swabs and nasopharyngeal aspirates obtained from Egyptian patients with laboratory-confirmed SARS-CoV-2 infection were isolated using Vero cells and were then genetically characterized. Vaccine inactivation was performed using diluted formaldehyde, followed by safety testing for the inactivated vaccine. To determine the high humoral immune responses against SARSCOV-2 infection, the safety and capacity of the vaccine prepared with alum adjuvant were tested. The immunogenicity and efficacy of the vaccine candidate was tested in vitro by a neutralization assay and in vivo using mouse models. Our results revealed a cytopathic effect which was observed 48 hours post infection and the viral particles were identified by rRT-PCR as SARS-CoV-2. Propagation of the isolated virus in ten serial passages on the Vero cells yielded a virus titer 7.5 log10 TCID50/ml. Complete inactivation of SARS-CoV-2 was observed at 37°C in 24 hours post treatment by diluted formaldehyde. Inactivated SARS-CoV-2 infected fluid safety was determined by absence of cytopathic effect by repeated passage in Vero cell line, indicating loss of virus infectivity. Virus inactivated by diluted formaldehyde showed no deaths or clinical symptoms in mice groups post intraperitoneal inoculation (0.5ml/mouse). EgySerVac-20 inactivated vaccine has safely induced high levels of neutralizing antibodies titers in mice, where 0.1 ml immunization dose showed protective efficacy against SARS-CoV-2 challenge in mice. This finding will support the future preclinical and clinical trials evaluation for our SARS-CoV-2 vaccine candidate in primates and human, respectively.
Levels of myosin heavy chain mRNA transcripts and protein isoforms in the fast extensor digitorum longus muscle of 7-month-old rats with chronic thyroid status alterations
Authors: Vadászová A , Hudecová S , Križanová O , Soukup T
Published: May 2022

We have studied the effect of chronic thyroid status alterations on the myosin heavy chain (MyHC) isoform composition (by SDS-PAGE) and on MyHC mRNA levels (by RT-PCR) in the fast extensor digitorum longus (EDL) muscle of 7-month-old inbred Lewis strain female rats and compared this with corresponding results of the previously studied slow soleus muscle. Our findings show that in the EDL muscle, all four types 1, 2a, 2x/d and 2b of MyHC mRNA transcripts and protein isoforms are present in euthyroid, hypothyroid and hyperthyroid rats, i.e. after chronic treatment with methimazole and T(3), respectively. This is in contrast with the soleus, where only MyHC1 and 2a protein isoforms are expressed under similar conditions. Except for 2x/d MyHC mRNA transcripts in the EDL muscles, there was always significant difference between hypothyroid and hyperthyroid rats both at mRNA and protein levels. From our results we can conclude that extended alteration of the thyroid status leads to typical changes in the expression of MyHC mRNA transcripts and MyHC protein isoforms in the fast EDL and the slow soleus muscles. These changes correspond to those described after shorter periods of altered thyroid status. The characteristic phenotype differences between soleus and EDL muscles remain, however, preserved even after 7 months of thyroid hormone status alteration.
Customer Reactions to Pop-Up Store Communications
Authors: Ghalia BOUSTANI
Published: May 2022

To date, research has focused on traditional or virtual store atmosphere influences on consumer behaviors. In the case of ephemeral stores, social media messages also stimulate consumers’ responses. Inspiring from a stimulus-response model, this study aims to investigate the nature of social media messages and the responses they elicit from consumers in the case of ephemeral stores. A sample of 25 fashion brands was observed through a “nethnography” for 3 months. Research findings showed that social media messages contribute to consumer online/offline journeys, promote customer-brand instant in-store exchanges, influence in-store behaviors and yield to information co-production.
Patients with Low Socioeconomic Status are More Likely to Present for Non-Elective Ovarian Cancer Surgery
Authors: Cohen Joshua G
Published: May 2022

Objective: Our objective was to characterize the association between demographic features and perioperative outcomes in patients undergoing non-elective ovarian cancer surgery. Methods: Women undergoing ovarian cancer surgery between 2010 and 2015 were identified in the Nationwide Readmissions Database. Patients were divided by whether they had elective or non-elective surgery. Demographic and clinical characteristics, post-operative outcomes including length of stay, adjusted costs at index hospitalization, readmission rates, and mortality were compared between groups. Multivariable analyses were employed to assess the association between baseline characteristics and non-elective surgery, and relevant clinical outcomes.
Respons Pertumbuhan Bibit Tanaman Kelapa Sawit (Elaeis guineensis Jacq.) Akibat Pemberian Pupuk Kascing dan Pupuk NPK Berbeda Dosis
Authors: Ariyanti Mira , Suherman Cucu , Rosniawaty Santi
Published: May 2022

Pembibitan merupakan salah satu tahapan penting yang akan menentukan tingkat pertumbuhandan perkembangan tanaman kelapa sawit selanjutnya. Oleh karena itu diperlukan perhatian yangberfokus pada penyediaan unsur hara bagi bibit kelapa sawit yang cukup baik secara kualitas maupunkuantitas. Dilakukan percobaan terkait hal ini yang dilaksanakan di kebun percobaan CiparanjeFakultas Pertanian Universitas Padjadjaran Kecamatan Jatinangor, Kabupaten Sumedang, Jawa Baratdengan ketinggian tempat 732 meter di atas permukaan laut. Metode yang digunakan dalam percobaanini adalalah percobaan lapangan menggunakan Rancangan Acak Kelompok yang terdiri dari tujuhperlakuan dan empat ulangan. Perlakuan meliputi: A = 10 g pupuk NPK, B = 1 kg pupuk kascing, C = 1kg pupuk kascing + 5 g pupuk NPK, D = 1 kg pupuk kascing + 2.5 g pupuk NPK, E = 2 kg pupukkascing, F = 2 kg pupuk kascing + 5 g pupuk NPK, G = 2 kg pupuk kascing + 2.5 g pupuk NPK. Datayang diperoleh diuji menggunakan SASM, jika hasil pengujiannya signifikan maka dilanjutkan denganUji Jarak Berganda Duncan pada taraf kepercayaan 95%. Hasil penelitian menunjukkan memberianpupuk kascing pada bibit kelapa sawit mampu mengurangi 50 75% dosis pupuk anorganik denganadanya respons pertumbuhan bibit kelapa sawit yang cukup baik. Pemberian 1-2 kg pupuk kascing yangdikombinasikan dengan dengan 2.5 5 g pupuk NPK berpengaruh nyata terhadap pertambahan jumlahdan luas daun serta luas kanopi bibit kelapa sawit fase pembibitan utama (main nursery).Kata kunci : bibit kelapa sawit, pupuk kascing, pupuk NPK
PENERAPAN KONSEP CORPORATE SOCIAL RESPONSIBILITY DALAM MENGEMBANGKAN UMKM MELALUI PROGRAM BRINCUBATOR
Authors: Widjaja Sharon Rose , Natakoesoemah Susilowati
Published: May 2022

CSR dilakukan sebagai bentuk kesadaran perusahaan untuk melakukan tanggung jawab terhadap masyarakat ataupun lingkungan sekitar operasional perusahaan. PT. Bank Rakyat Indonesia (Persero) Tbk yang merupakan perusahaan di industri perbankan yang memiliki fokus di bidang bisnis mikro, membentuk kegiatan CSR untuk mengembangkan UMKM melalui kolaborasi dengan Desk Inkubasi dengan Program BRIncubator. Program ini bertujuan mengembangkan UMKM untuk melakukan ekspor serta membentuk Digital Economy Ecosystem sesuai dengan arahan Kementerian BUMN. Penelitian ini dibuat untuk mengetahui bagaimana penerapan CSR serta prinsip-prinsip CSR yang dilakukan untuk mengembangan UMKM. Penelitian ini menggunakan metode kualitatif deskriptif. Peneliti menggunakan pencarian data primer melalui wawancara semi struktur serta melakukan riset melalui data perusahaan, buku, jurnal dan situs web. Hasil penelitian yang didapat adalah pengembangan UMKM yang dilakukan oleh Program BRIncubator dalam penerapan CSR masih sulit dilakukan oleh UMKM, sehingga UMKM melakukan CSR dengan cara melakukan produksi produk dengan bahan ramah lingkungan. Prinsip-prnsip CSR yang telah dilaksanakan dengan baik walaupun masih kurang dalam hal pemberitahuan secara langsung terkait pelatihan UMKM merupakan bagian dari CSR perusahaan. Selanjutnya untuk pengembangan UMKM terdapat beberapa kendala dari pihak eksternal yang masih belum melek teknologi sehingga menghambat pelatihan UMKM, disarankan pelatihan UMKM untuk dipecah kelasnya agar sesuai dengan kemampuan UMKM mengenai digitalisasi serta perlu adanya pengkomunikasian mengenai Program BRIncubator merupakan bagian dari CSR Bank BRI.Kata Kunci: Corporate Social Responsibility, Komunikasi Korporat, UMKM
VISUALISASI GREEN CAMPUS UNIVERSITAS KUNINGAN DALAM PANORAMA FOTOGRAFI PANOSPHERE
Authors: Kusuma Sigit Setya , Herlina Elin
Published: May 2022

Penelitian sekaligus penciptaan yang dibuat adalah Visualisasi Green Campus Universitas Kuningan dalam Fotografi Panosphere. Penelitian ini mempunyai tujuan yaitu menciptakan visualisasi Green Campus panorama yang menarik dengan gaya panosphere dan mengenalkan gaya fotografi panosphere pada masyarakat umum dan seluruh mahasiswa Universitas Kuningan pencinta seni fotografi. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Pada penciptaan karya fotografi, penulis melakukan observasi dengan menyusun bahasan penelitian. Pengumpulan dilakukan dengan berbagai metode seperti: eskplorasi, observasi, pemilihan objek, dan studi pustaka. Sebelum proses eksekusi karya, perlu memilih objek kampus menjadi pertimbangan penting dalam fotografi panosphere. Karena Universitas Kuningan memiliki point dalam visual keindahan untuk dijadikan objek dalam panosphere sehingga menampilkan pemandangan kampus yang berbeda. Objek dalam penelitian ini adalah Universitas Kuningan. Hasil dari penelitian tersebut berupa karya fotografi yang menjadi proses pengetahuan tentang proses kreatif membuat sebuah karya fotografi seni. Pembentukan karya foto yang sudah diseleksi atau dipilih selanjutnya melakukan teknik stitching dengan menggunakan Adobe Photoshop. Pengolahan yang dilakukanya itu merangkai semua foto yang sudah di bidik menajdi satu bentuk bulatan dengan satu kesatuan, pengolahan selanjutnya sebatas mengolah perubahan level, brigthnes, cropping dan selective color. Selain matang secara konsep, dapat memiliki pengalaman seni tentang fotografi. Ketertarikannya dengan pilihan objek visualisasi Green Campus yaitu menjadi sebuah tantangan tersendiri bagaimana visualisasi tersebut bisa menampilkan suasana yang sesuai dengan tema tersebut.Kata Kunci: Visualisasi, Green Campus, Panorama, Fotografi Panosphere
KOMODIFIKASI ISI BERITA KECELAKAAN PESAWAT SRIWIJAYA AIR SJ-182 DI OKEZONE.COM (Analisis Wacana Kritis Van Djik)
Authors: Syaefudin Mochamad , Budiwinarto Arif
Published: May 2022

Bencana bukan hanya permasalahan sosial tetapi bencana telah menjadi komoditas yang seksi di media online indonesia. Penelitian ini bertujuan untuk menganalisis bentuk komodifikasi isi bencana yang ada pada pemberitaan kecelakaan pesawat Sriwijaya Air SJ-182 pada portal berita daring okezone.com. Penelitian ini menggunakan metode kualitatif untuk menganalisis bentuk komodifikasi bencana yang dimuat dalam media daring tersebut. Hasil penelitian menunjukan bahwa dalam pemberitaannya okezone.com memparaktikkan bentuk komodifikasi isi dalam menyoroti kecelakaan pesawat Sriwijaya Air SJ-182. Okezone.com memunculkan lebih banyak aspek dramatis dari insiden tersebut ketimbang mendorong kesiapsiagaan ataupun menggali informasi tentang penyebab jatuhnya pesawat Sriwijaya Air yang memakan banyak korban sehingga dapat dijadikan pelajaran agar kasus serupa tidak terulang.Kata Kunci: Komodifikasi, Berita, Kecelakaan, Sriwijaya Air, Okezone.com
TRADISI CINGCOWONG BILGUNA BILAMANA DI SANGGAR SRI BUANA RAHAYU KECAMATAN LURAGUNG KABUPATEN KUNINGAN
Authors: Komalasari Anik , Siswoyo Mukarto , Wihayati Welly
Published: May 2022

Tari Cingcowong dikenal oleh masyarakat sebagai turun wadon atau turun temurun pada perempuan ke turunan perempuan kembali. Cingcowong berasal dari kata cing berarti terka, cowong kependekan dari wong yang dalam bahasa jawa berarti orang. Awal mulai adanya cingcowong yakni oleh seorang punduh atau yang diyakini pada masa itu sebagai seorang spiritual yang dikenal masyarakat sekitar adalah mbok kukuh. Mbok kukuh ini diperintah oleh seorang kuwu desa yang bernama Kertasantana untuk mengadakan ritual pemanggil hujan, dikarenakan pada saat itu desa sedang mengalami kemarau panjang selama 18 bulan lama nya, sehingga mengakibatkan lahan pertanian yang menjadi mata pencaharian masyarakat sekitar mengalami kerugian. Makna dari tari cingcowong ini sebagai bentuk rasa ucapan syukur masyarakat Luragung kepada Tuhan Yang Maha Esa dan bentuk ikhtiar. Adapun urgensi dan kontribusi penelitian selain sebagai wujud upaya melestarikan dan menjaga nilai-nilai kearifan lokal masyarakat Luragung khususnya, dan mengungkap tanda dan makna di dalam tarian cingcowong serta agar diapresiasi sehingga mengetahui makna yang sesungguhnya. Penelitian ini menggunakan metode deskriptif kualitatif dengan analisis semiotika melalui pengumpulan data studi pustaka dan studi lapangan. Hasil penelitian bahwa tari cingcowong saat ini sebagai pop art atau hiburan bagi masyarakat tetapi tidak mengurangi nilai sejarah yang ada.Kata-kata Kunci: Tradisi, Semiotika, Tari Cingcowong Bilguna Bilamana
PENGARUH VIDEO IKLAN YOUTUBE �TOKOPEDIA x BLACKPINK WAKTUNYA INDONESIA BELANJA!� TERHADAP RESPONS KONSUMEN PADA KALANGAN GENERASI Z DI JAKARTA
Authors: Firdaus Adam Rizky , Hartoyo Reksa
Published: May 2022

Pada tahun 2021 media sosial Youtube berkembang dengan pesat di Indonesia. Di balik perkembangannya yang pesat Youtube memiliki banyak sekali manfaat tidak terkecuali manfaat bagi para pelaku bisnis online. Manfaat Youtube untuk mempromosikan produk-produk dan jenama bagi para pelaku bisnis online. Program yang di rancang oleh Youtube dalam mempromosikan produk yaitu Youtube Advertising. Salah satu perusahaan yang melakukan promosi melalui iklan di youtube adalah Tokopedia. Di mana tujuan pada penelitian ini untuk mengetahui pengaruh dari Video Iklan Youtube Tokopedia x Blackpink Waktunya Indonesia Belanja Terhadap Respons Konsumen Pada Kalangan Generasi Z di Jakarta. Teknik sampel yang digunakan adalah Non-Probability Sampling. Jumlah sampel dalam penelitian ini adalah 100 responden dengan karakteristik kalangan generasi Z di wilayah DKI Jakarta yang telah atau sudah menonton iklan Tokopedia x Blackpink di Youtube. Hasil dari penelitian menunjukan bahwa pengaruh antara video iklan youtube Tokopedia x Blackpink Waktu Indonesia Belanja terhadap respons konsumen menunjukan hasil yang kuat di mana dapat di lihat dari variabel Respons Konsumen memiliki nilai Cronbachs Alpha diatas 0,6 yaitu 0,954.
Model Komunikasi Dinas Pengendalian Penduduk dan Keluarga Berencana Kota Pekanbaru dalam Meningkatkan Pemberdayaan Usaha Peningkatan Pendapatan Keluarga Akseptor (UPPKA) di Kota Pekanbaru
Authors: Dewi Intan Kumala
Published: May 2022

Program Usaha Peningkatan Pendapatan Keluarga Akseptor (UPPKA) merupakan merupakan kelompok kegiatan pendukung proram KB yang anggotanya terdiri dari keluarga Pra Sejahtera dan Keluarga sejahtera I, dalam rangka peningkatan kesejahteraan keluarga melalui kegiatan wirausaha dibawah binaan DISDALDUK-KB Kota Pekanbaru di tingkat Kabupaten/Kota. Dalam kegiatannya meningkatkan pemberdayaan UPPKA di Kota Pekanbaru, DISDALDUK-KB Kota Pekanbaru tentu pernah mengalami gangguan atau misskomunikasi dengan kelompok UPPKA di Kota Pekanbaru. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana bentuk model komunikasi Dinas Pengendalian Penduduk dan Keluarga Berencana (DISDALDUK-KB) Pekanbaru dalam Meningkatkan Pemberdayaan Usaha Peningkatan Pendapatan Keluarga Akseptor (UPPKA) di Kota Pekanbaru. Penelitian ini menggunakan metode penelitian kualitatif dengan menghasilkan data deskriptif dari yang diteliti.. Tekhnik penulisan datanya dengan observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukkan bentuk model komunikasi DISDALDUK-KB Kota Pekanbaru dalam meningkatkan pemberdayaan UPPKA di Kota Pekanbaru adalah gabungan dari unsur komunikasi DeVito dengan model komunikasi David Corten. dimana DISDALDUK-KB Kota Pekanbaru, dan Kelompok UPPKA saling berinteraksi dalam proses pemberdayaan kelompok UPPKA. Output dari program UPPKA berasal dari kebutuhan dan permintaan kelompok UPPKA. DISDALDUK-KB Kota Pekanbaru memiliki tupoksi dari program UPPKA yang beriringan dengan kompetensi dan etika untuk memenuhi tanggung jawab memfasilitasi kelompok UPPKA. Model komunikasi ini diharapkan dapat mewujudkan tujuannya meningkatkan pemberdayaan UPPKA di Kota Pekanbaru.
ANALISIS SEBARAN HOAKS PADA FACEBOOK PERIHAL INFO SEPUTAR COVID-19
Authors: Edy Sarwo , Florina Ike Desi
Published: May 2022

Kondisi pandemic yang baru dirasakan oleh masyarakat Indonesia diawal tahun 2020 yang lalu membuat perubahan tatanan kehidupan yang cukup signifikan. Masyarakat yang masih kurang dalam literasi Covid-19 sangat rentang sekali terhadap beritata borong (hoax) yang masih tersebar di media social terutama facebook. Penelitian ini bertujuan untuk menjelaskan bagaimana pola penyebaran hoaks di Facebook perihal informasi covid-19. Penelitian ini menggunakan teori Computer Mediated Communication (CMC) dan menggunakan metode deskriptif kualitatif. Hasilnya mengungkapkan informasi hoaks covid-19 pertama muncul di Facebook pada tanggal 26 Januari 2020, kemudian Facebook menjadi platform tertinggi dalam penyebaran hoaks (3.463 isu) yang dipercayai masyarakat sehingga salah satu sebab terhambatnya penanganan pandemic di Indonesia. Sedangkan dari analisis model Interactivity CMC dengan empat point utama (user, medium, message, dan communication setting), ditemukan bahwa user memiliki motif yang beragam dalam melakukan penyebaran hoaks, yakni melalui jenis hoaks yang disebarkannya. Pada medium, karakter Facebook yang tidak memerlukan banyak kuota memudahkan dalam mengaksesnya, serta fitur share yang memudahkan berbagi informasi, termasuk hoaks mengenai covid-19. Dari sisi message, pesan yang disebarluaskan oleh Facebook memiliki dampak atau pengaruh yang cukup signifikan terhadap pembentukan persepsi hingga opini public. Terakhir dari sisi comunication setting adalah Facebook dengan penawaran fiturnya menarik perhatian pengguna, link Facebook dengan media sosial lainnya seperti Instagram membuat semakin massifnya penyebaran informasi hoaks termasuk mengenai pandemic Covid-19.
Takvâ Ve Ahlakta İstikâmet
Authors: Tosun Necdet
Published: May 2022

İstikâmet, yanlış yollara sapmadan doğru yolda yürümek demektir. İslam ahlâkında istikâmet denince de ifrat ve tefrite yani yanlış yorumlara dalmadan i’tidâl üzere ahlâkı yaşamak, orta yoldan ve mâkul çizgiden ayrılmamak anlaşılır. Bir diğer ifâdeyle istikâmet, Allah Rasûlü’nün örnek şahsiyetinden nasîb almak, ahlâkı ile ahlâklanmak, bir ömür Kur’ân ve Sünnet’in öngördüğü çizgide yaşamaktır. İslam denge dinidir. Aşırılıklardan uzak durmayı ve orta yolu tavsiye eder. Bununla birlikte ahlâkî bazı konuları anlama ve uygulama konusunda asr-ı saâdetten itibaren bazı sapmalar görülmüştür. Bu sapmalar asr-ı saâdette bizzat Hz. Peygamber veya Hz. Ömer gibi kişiler tarafından düzeltilip tashih edilmiş, yanlış yorumlara kayanlar uyarılmıştır. Sonraki asırlarda, özellikle fetihlerin genişlemesiyle birlikte toplumda oluşan zenginlik bazı insanları lüks elbise giyme, konforlu evlerde oturma ve dünya malına hırsla sarılma gibi zaaflara sevk edince, buna karşı bir tepki olarak toplumdaki bazı zâhid insanlar daha ahlaklı ve takvâ üzere yaşama arzusuna yönelmişler, bu arada bazı kişiler aşırıya giderek yanlış yorumlara kaymışlardır. Çalışıp kazanmayı tevekküle aykırı gören, mağaralarda uzlete çekilen, tevekkülü yanlış anlayıp azık almadan çöl yollarına düşen, çok az yedikleri için zayıf düşüp ibadetten geri kalan insanlar olmuştur. İslam’ın tavsiye ettiği ahlak çizgilerinin dışına çıkan bu insanlar hem âlimler hem de kendileri gibi zâhid ve sûfî olan kişiler tarafından uyarılmış, bu konuda tasavvuf ehli tarafından müstakil kitaplar ya da kitapta bölümler yazılmıştır. Bu sayede ahlak ve takvânın doğru anlaşılması ve istikâmet üzere yaşanması konusunda önemli prensipler ortaya konmuştur.
Investigating the Role of Spermidine in a Model System of Alzheimer’s Disease Using Correlative Microscopy and Super-resolution Techniques
Authors: Lumkwana D. , Peddie C. , Kriel J. , Michie L. L. , Heathcote N. , Collinson L. , Kinnear C. , Loos B.
Published: May 2022

Background: Spermidine has recently received major attention for its potential therapeutic benefits in the context of neurodegeneration, cancer, and aging. However, it is unclear whether concentration dependencies of spermidine exist, to differentially enhance autophagic flux. Moreover, the relationship between low or high autophagy activity relative to basal neuronal autophagy flux and subsequent protein clearance as well as cellular toxicity has remained largely unclear.

Methods: Here, we used high-resolution imaging and biochemical techniques to investigate the effects of a low and of a high concentration of spermidine on autophagic flux, neuronal toxicity, and protein clearance in in vitro models of paraquat (PQ) induced neuronal toxicity and amyloid precursor protein (APP) overexpression, as well as in an in vivo model of PQ-induced rodent brain injury.

Results: Our results reveal that spermidine induces autophagic flux in a concentration-dependent manner, however the detectable change in the autophagy response critically depends on the specificity and sensitivity of the method employed. By using correlative imaging techniques through Super-Resolution Structured Illumination Microscopy (SR-SIM) and Focused Ion Beam Scanning Electron Microscopy (FIB-SEM), we demonstrate that spermidine at a low concentration induces autophagosome formation capable of large volume clearance. In addition, we provide evidence of distinct, context-dependent protective roles of spermidine in models of Alzheimer’s disease. In an in vitro environment, a low concentration of spermidine protected against PQ-induced toxicity, while both low and high concentrations provided protection against cytotoxicity induced by APP overexpression. In the in vivo scenario, we demonstrate brain region-specific susceptibility to PQ-induced neuronal toxicity, with the hippocampus being highly susceptible compared to the cortex. Regardless of this, spermidine administered at both low and high dosages protected against paraquat-induced toxicity.

Conclusions: Taken together, our results demonstrate that firstly, administration of spermidine may present a favourable therapeutic strategy for the treatment of Alzheimer’s disease and secondly, that concentration and dosage-dependent precision autophagy flux screening may be more critical for optimal autophagy and cell death control than previously thought.