bluuebunny/crossref_metadata_2025 huggingface dataset:
Surviving Material Poverty by Employing Cultural Wealth: Putting Music in the Service of Community in Haiti
Authors: Dirksen Rebecca
Published: November 2013

Haiti and its citizens are frequently squeezed between a confusing and uneasy pair of polarizing superlatives: the Caribbean nation is routinely identified as “the poorest country in the Western Hemisphere” at the same time that its culture is upheld as one of the richest in the post-colonial Americas. Although these labels can (and probably should) be dismissed as oversimplified and destructive, they do offer a striking dichotomy to contemplate. Can seeming economic poverty be balanced against so-called cultural richness? Can the domains of economy and culture be reconciled as mutually useful? Specifically, can culture be exploited to enhance daily life and improve material existence?
The Limits and Ambivalences of Postcolonial Consciousness in Mbunga'sChurch Law and Bantu Music
Authors: Sanga Imani
Published: November 2013

A Tanzanian Roman Catholic priest, the late Stephen B. G. Mbunga (1927–1982), has played a significant role in the history of church music in Tanzania through his compositions, involvement in music performance as a choral conductor, and scholarly writing on various aspects of church music. He is best known by scholars of the music of Tanzania through his work on the localization of church music there. In his 1963 book entitledChurch Law and Bantu Music: Ecclesiastical Documents and Law on Sacred Music as Applied to Bantu Music,which was his doctoral dissertation (a work completed at and submitted to Propaganda University in Switzerland), he strongly defends the use of African music in Roman Catholic Church services in Africa. After interpreting Roman ecclesiastical laws and various directives given by top officials in the Roman Catholic Church, Mbunga argues that the use of African music in the Roman Catholic Church is consistent with and can be accomplished in accordance with these laws and directives concerning church music (see Sanga 2011:35–37). He also proposes practical ways through which musicians can undertake the task of composing African music that is appropriate for Roman Catholic Church services.
Libéralités et personnes âgées : entre autonomie et protection
Authors: Morin Christine
Published: November 2013

Avec le vieillissement de la population surgissent des questions juridiques importantes, entre autres en matière de transmission du patrimoine des personnes âgées. Plusieurs aînés possèdent un patrimoine dont la valeur est considérable et ils sont susceptibles de le transmettre à court ou à moyen terme, notamment au moyen de libéralités. Or, on sait que le contentieux relatif aux libéralités consenties par des personnes âgées est abondant. La lecture de la jurisprudence nous apprend par ailleurs que plusieurs motifs de contestation sont en lien avec l’âge de l’auteur de la libéralité.

Devant ce constat, il y a lieu de s’interroger pour savoir s’il faut effectivement se méfier des libéralités des aînés. Les personnes âgées nécessitent- elles une protection particulière à ce chapitre?

Nombreux sont les spécialistes qui mettent en garde contre l’âgisme. Par contre, il convient de distinguer les comportements « âgistes » des comportements « en fonction de l’âge d’une personne ». Si le premier type de comportement résulte de croyances erronées et de stéréotypes envers les personnes âgées, le second peut, au contraire, constituer un comportement approprié en raison de l’âge d’une personne.

Sachant que ces deux types de comportement à l’égard des aînés existent, cet article a pour objectif d’étudier comment « l’âge avancé » de l’auteur d’une libéralité influence le raisonnement des juges. Quel est l’impact des représentations sociales associées à l’âge dans les décisions judiciaires rendues en matière de libéralités? S’il est vrai que le droit se méfie généralement des libéralités, qu’en est-il lorsqu’une personne aînée en est l’auteure?
La fiducie française ou le réveil chaotique d’une « belle au bois dormant »
Authors: Barrière François
Published: November 2013

La fiducie, connue déjà de Rome, a longtemps été espérée en France. Sans attendre sa reconnaissance sous forme d’institution nommée, de nombreuses techniques juridiques en portaient tous les traits, avec certes un domaine d’application spécifique. Moins qu’une révolution juridique, l’introduction de la fiducie nommée aurait alors dû être une évolution paisible du droit français. Il n’en fut rien. Sa naissance a été chaotique. C’est une petite fiducie qui est née. Son champ d’application était, alors, étroitement limité, illustration de craintes persistantes de l’administration fiscale notamment avec une discrimination de capacité quant aux constituants regrettable. La rupture avec l’unité du patrimoine a toutefois été consommée dès l’origine. Et la nature du droit détenu par le fiduciaire n’a pas manqué de donner lieu à débat. La qualité du texte législatif initialement voté laissait à désirer, illustration d’une tendance des temps modernes. Progressivement, le cadre légal s’est amélioré; le régime juridique s’est affiné pour aujourd’hui s’être stabilisé et offrir un corpus davantage cohérent à l’institution fiduciaire. Cela est peut-être signe que l’introduction de cette « belle au bois dormant » dans un terreau de droit civil a besoin de temps pour s’acclimater.
La fiducie-sûreté en droit français
Authors: Barrière François
Published: November 2013

Lorsque la situation financière devient tendue, que l’octroi de crédit se fait plus difficile, que la situation économique se détériore, que les risques de recouvrement des créances augmentent, l’intérêt d’une sûreté efficace en faveur du prêteur apparaît encore plus nettement que d’habitude. La sûreté-propriété constituée par la fiducie devrait donc paraître comme un moyen idoine d’apporter la sécurité recherchée par les prêteurs et participer ainsi à fluidifier le circuit du crédit, voire à faciliter certaines restructurations d’entreprises. Mais l’intérêt du débiteur en « faillite » ne doit pas être négligé non plus et l’objectif de sauvegarde de l’entreprise en difficulté avec la sécurité attachée à la sûreté doit être concilié.

L’intérêt de la fiducie-sûreté est triple. D’abord, le créancier est particulièrement bien protégé grâce à l’exclusivité du droit de propriété qui lui est transférée. Ensuite, la constitution d’une telle sûreté est aisée. Enfin, la réalisation de la fiducie-sûreté en période de procédure collective offre un régime avantageux à son bénéficiaire. Cette sûreté pourrait donc, indépendamment de périodes de crise du crédit, se développer de manière notable. La fiducie-sûreté nommée pourrait-elle alors devenir reine des sûretés ?
Supershear rupture of the 5 January 2013 Craig, Alaska (Mw7.5) earthquake
Authors: Yue Han , Lay Thorne , Freymueller Jeffrey T. , Ding Kaihua , Rivera Luis , Ruppert Natalia A. , Koper Keith D.
Published: November 2013

Supershear rupture, in which a fracture's crack tip expansion velocity exceeds the elastic shear wave velocity, has been extensively investigated theoretically and experimentally and previously inferred from seismic wave observations for six continental strike‐slip earthquakes. We find extensive evidence of supershear rupture expansion of an oceanic interplate earthquake, the 5 January 2013Mw = 7.5 Craig, Alaska earthquake. This asymmetric bilateral strike‐slip rupture occurred on the Queen Charlotte Fault, offshore of southeastern Alaska. Observations of first‐arrivingSnandSgshear waves originating from positions on the fault closer than the hypocenter for several regional seismic stations, with path calibrations provided by an empirical Green's function approach, indicate a supershear rupture process. Several waveform inversion and modeling techniques were further applied to determine the rupture velocity and space‐time distribution of slip using regional seismic and geodetic observations. Both theoretical and empirical Green's functions were used in the analyses, with all results being consistent with a rupture velocity of 5.5 to 6 km/s, exceeding the crustal and upper mantleSwave velocity and approaching the crustalPwave velocity. Supershear rupture occurred along ~100 km of the northern portion of the rupture zone but not along the shorter southern rupture extension. The direction in which supershear rupture developed may be related to the strong material contrast across the continental‐oceanic plate boundary, as predicted theoretically and experimentally. The shear and surface wave Mach waves involve strongly enhanced ground motions at azimuths oblique to the rupture direction, emphasizing the enhanced hazard posed by supershear rupture of large strike‐slip earthquakes.
Conjugated Polyelectrolyte and Aptamer Based Potassium Assay via Single‐ and Two‐Step Fluorescence Energy Transfer with a Tunable Dynamic Detection Range
Authors: Nguyen Bao Lam , Jeong Ji‐Eun , Jung In Hwan , Kim Boram , Le Van Sang , Kim Inhong , Kyhm Kwangseuk , Woo Han Young
Published: November 2013

A new potassium ion detection assay was developed using a dye‐labeled aptamer and conjugated polyelectrolyte (CPE) as a signaling platform via 1‐step and 2‐step fluorescence resonance energy transfer. Guanine‐rich K+‐specific aptamers were designed as K+ ion recognition species with 6‐carboxyfluorescein (6‐FAM) and 6‐carboxytetramethylrhodamine (6‐TAMRA) at both termini. In the presence of K+ ions, the aptamers undergo a conformational change from an unfolded to folded form by forming a G‐quadruplex with K+, bringing two dyes in proximity. FRET‐induced 6‐TAMRA emission was proportional to [K+] in a range of 22.5 μm–100 mm in water without interference by the presence of excess Na+ ions (100 mm). Upon the addition of CPE, a two‐step FRET process from CPE to 6‐TAMRA via 6‐FAM was enabled, showing an intensified 6‐TAMRA signal with K+ ions. The dynamic detection range and limit of detection (LOD) was fine‐tuned from ∼millimolar to ∼nanomolar concentrations of K+ by modulating the signal amplification effect of CPE. The LOD was determined to be ≈3.0 nm. This detection assay also showed high selectivity against other metal ions. This sensing scheme can be extended to the detection of a wide range of target materials by simply modifying the recognition aptamer sequence.
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Authors: Annabi Nasim , Tamayol Ali , Uquillas Jorge Alfredo , Akbari Mohsen , Bertassoni Luiz E. , Cha Chaenyung , Camci‐Unal Gulden , Dokmeci Mehmet R. , Peppas Nicholas A. , Khademhosseini Ali
Published: November 2013

Hydrogels are hydrophilic polymer‐based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three‐dimensional (3D) matrices for tissue engineering, drug‐delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light‐sensitive, composite, and shape‐memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life.
Cobalt Carbonyl‐Based Catalyst for Hydrosilylation of Carboxamides
Authors: Dombray Thomas , Helleu Camille , Darcel Christophe , Sortais Jean‐Baptiste
Published: November 2013

The cobalt carbonyl [Co2(CO)8] complex is employed as a useful catalyst for the reduction of tertiary amides to the corresponding tertiary amines using 1,1,3,3‐tetramethyldisiloxane (TMDS) and poly(methylhydrosiloxane) (PMHS) as silane reagents under thermal (100 °C) or photo‐assisted conditions (UV, 350 nm at room temperature). Of particular interest, a low catalytic amount (0.5 mol%) of [Co2(CO)8] is used to perform the reaction with 2.2 equiv. of PMHS at 100 °C for 3 h. This reaction is the first example of a cobalt‐catalyzed hydrosilylation of amides.

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High Diastereoselectivity Induced by a Fluorous Alkyl Group in the Asymmetric Michael Reaction of Nitroalkenes Catalyzed by a Prolinol Methyl Ether
Authors: Funabiki Kazumasa , Ohta Masaya , Sakaida Yuta , Oida Kiyofumi , Kubota Yasuhiro , Matsui Masaki
Published: November 2013

The fluorous prolinol methyl ether was prepared through the perfluorohexylethylation of (S)‐1‐tert‐butyl 2‐methyl pyrrolidine‐1,2‐dicarboxylate using commercially available perfluorohexylethyl iodide, methylation, and deprotection in three steps in 19 % overall yield. In the asymmetric Michael addition reaction of nitrostyrene with propanal, the diastereoselectivity (syn/anti=92:8) with the prepared fluorous prolinol methyl ether was much higher than that (syn/anti=87–80:13–20) with nonfluorinated prolinol methyl ethers that have two n‐octyl groups or two phenyl groups in place of perfluorohexylethyl groups.
Damage‐associated molecular patterns stimulate interleukin‐33 expression in nasal polyp epithelial cells
Authors: Paris Gina , Pozharskaya Tatyana , Asempa Tomefa , Lane Andrew P.
Published: November 2013

Background

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disorder characterized by eosinophilic inflammation and local T‐helper 2 (Th2) cytokine production. Innate lymphoid cells that elaborate Th2 cytokines have recently been characterized within nasal polyps. These cells can be activated by the epithelial cell‐derived cytokine interleukin‐33 (IL‐33). The objective of this study is to determine whether 2 molecules associated with tissue damage (high mobility group box‐1 [HMGB‐1] and adenosine triphosphate [ATP]) elicit expression of IL‐33 in sinonasal epithelial cells (SNECs) derived from recalcitrant CRSwNP patients.

Methods

Ethmoid tissue was obtained from 8 recalcitrant CRSwNP and 9 control subjects during endoscopic sinus surgery (ESS). Tissue was prepared for immunohistochemistry and for SNEC air‐liquid interface culture. After exposure to either HMGB1 or ATP in vitro, SNECs were processed for messenger RNA (mRNA) extraction and immunocytochemistry. IL‐33 levels were determined by real‐time polymerase chain reaction (PCR) and by immunochemical staining with anti‐IL‐33 antibody.

Results

Intranuclear IL‐33 is normally expressed in basal epithelial cells, but is present in more apical cells and outside the nucleus in CRSwNP. Exposure of SNECs to HMGB‐1 or ATP resulted in a statistically significant increase in IL‐33 mRNA expression in SNECs derived from recalcitrant CRSwNP patients. This increase was reflected at the protein level by immunochemical staining of IL‐33.

Conclusion

Tissue damage is a nonspecific trigger of epithelial IL‐33 production in treatment‐recalcitrant polyps, which may be responsible for perpetuating eosinophilic inflammation in CRSwNP. This common pathway may help explain why multiple environmental and infectious agents have been implicated in CRSwNP exacerbation.
Master equation approach to conductivity of bosonic and fermionic carriers in one‐ and two‐dimensional lattices
Authors: Kolovsky Andrey R.
Published: November 2013

The master equation approach to diffusive current of bosonic or fermionic carriers in one‐ and two‐dimensional lattices is discussed. This approach is shown to reproduce all known results of the linear response theory, including the integer quantum Hall effect for fermionic carriers. The main advantage of the approach is that it allows to calculate the current beyond the linear response regime where new effects are found. In particular, the Hall current can be inverted by changing orientation of the static force (electric field) relative to the primary axes of the lattice.
Modelling predicted sperm whale habitat in the central Mediterranean Sea: requirement for protection beyond the Pelagos Sanctuary boundaries
Authors: Aïssi Mehdi , Ouammi Ahmed , Fiori Cristina , Alessi Jessica
Published: November 2013

Climate change and human activities impacts are considered to be the main causes of sperm whale habitat alteration.

Despite the creation of several marine protected areas in the Mediterranean Sea, the sperm whale status remains ‘endangered’. Its spatial distribution has been reported in different areas of the Mediterranean, among them the Pelagos Sanctuary.

Various biophysical parameters have been recognized to influence sperm whale distribution depending on the modelling scale. Hence, this study investigates and predicts sperm whale relative occurrence, taking into account the parameters that affect their habitats in the central Mediterranean Sea, inside and beyond the boundaries of the Pelagos Sanctuary.

An artificial neural network (ANN) model was used to predict the probability of sperm whale occurrence in the central Mediterranean Sea, for each cell of a 3 × 3 minute grid using a Visual Basic script to interface with GIS software. The algorithm was trained using species presence/absence data and a set of physiographic variables such as depth, slope, distance to shore and magnetic field.

Some geographic areas exhibit a consistently high probability of occurrence and may be identified as highly used areas for special management concern. Thus, this work represents a preliminary evaluation of management and conservation effort outside the Pelagos Sanctuary. The map of sperm whale predicted relative presence can be used to mitigate potentially harmful human activities and to support the design and management of marine protected areas, including the delineation of ecologically meaningful boundaries.

Copyright © 2013 John Wiley & Sons, Ltd.
Copper‐Catalyzed CH Bond Direct Chalcogenation of Aromatic Compounds Leading to Diaryl Sulfides, Selenides, and Diselenides by Using Elemental Sulfur and Selenium as Chalcogen Sources Under Oxidative Conditions
Authors: Shibahara Fumitoshi , Kanai Takafumi , Yamaguchi Eiji , Kamei Akika , Yamauchi Takayuki , Murai Toshiaki
Published: November 2013

The reactions of aromatic compounds and elemental chalcogens catalyzed by a copper salt with molecular oxygen as an oxidant were carried out. The reaction of 3‐substituted imidazo[1,5‐a]pyridines and elemental sulfur in the presence of CuTC (copper(I) thiophenecarboxylate) gave the corresponding bisimidazopyridyl sulfides in good to quantitative yields. The reaction proceeded even under aerobic oxidation conditions. The use of a polar solvent was crucial for the reaction, and DMSO (dimethyl sulfoxide) in particular stimulated the reaction. The reaction could be applied to common aromatic compounds, such as N‐methyl indole and dialkyl anilines. The reaction of indole proceeded at the nucleophilic C3 position rather than at the acidic C2 position. In addition, the reaction of dialkyl anilines proceeded with an ortho, para orientation. The reactions of imidazopyridines and elemental selenium under similar conditions gave the corresponding bisimidazopyridyl diselenides along with bisimidazopyridyl monoselenides. The resulting diselenides were readily converted to the corresponding monoselenides with unreacted imidazopyridines under the same conditions. The reaction could be applied to the copolymerization of bifunctional bisimidazopyridines and elemental sulfur to give oligomeric copolymers in quantitative yield.
Hydrophobic Variations of N‐Oxide Amphiphiles for Membrane Protein Manipulation: Importance of Non‐hydrocarbon Groups in the Hydrophobic Portion
Authors: Chae Pil Seok , Sadaf Aiman , Gellman Samuel H.
Published: November 2013

Amphipathic agents called detergents serve as membrane‐mimetic systems to maintain the native structures of membrane proteins during their manipulation. However, membrane proteins solubilized in conventional detergents tend to undergo denaturation and aggregation, necessitating the development of novel amphipathic agents with enhanced properties. Here we describe several new amphiphiles that contain an N‐oxide group as the hydrophilic portion. The new amphiphiles have been evaluated for the ability to solubilize and stabilize a fragile multi‐subunit assembly from biological membranes. We found that cholate‐based agents were promising in supporting retention of the native protein quaternary structure, while deoxycholate‐based amphiphiles were highly efficient in extracting/solubilizing the intact superassembly from the native membrane. Monitoring superassembly solubilization and stabilization as a function of variation in amphiphile structure led us to propose that a non‐hydrocarbon moiety such as an amide, ether, or a hydroxy group present in the lipophilic regions can manifest distinctive effects in the context of membrane protein manipulation.
A Relaxed Gradient Based Algorithm for Solving Extended Sylvester‐Conjugate Matrix Equations
Authors: Ramadan Mohamed A. , El‐Danaf Talaat S. , Bayoumi Ahmed M. E.
Published: November 2013

In this paper, a relaxed gradient based algorithm for solving extended Sylvester‐conjugate matrix equations by considering a relaxation parameter is proposed. The convergence analysis of the algorithm is investigated. Theoretical analysis shows that the new method converges under certain assumptions. A numerical example is given to illustrate effectiveness of the proposed method and to test its efficiency compared with an existing one.
Schubverformungen von Stabtragwerken in der praktischen Anwendung
Authors: Eierle Benno , Bös Burkhard
Published: November 2013

Schubverformungen werden bei der Berechnung von schlanken Stabtragwerken in der Ingenieurpraxis häufig vernachlässigt, da sie lediglich einen geringen Anteil der Gesamtverformung ausmachen. Bei gedrungenen Stäben können die Verformungen aus Querkräften jedoch eine relevante Größenordnung erreichen. Dieser Aufsatz stellt die Grundlagen zur Berücksichtigung der Schubverformungen in der Balkentheorie dar und leitet daraus Bemessungshilfen für die Beurteilung und Berechnung der Schubverformungen bei statisch bestimmten Systemen ab.

Shear deflections of beam structures in practical application

In the practical application of calculating slender beam structures the shear deflections are often neglected, since their portion of the total deformation is small. For deep girders however the shear deflections may reach a significant size. This paper explains the principles of shear deflections in the beam theory and gives design aids to assess and to calculate shear deflections for statically determinate systems.
Leichte Schalen aus hochfestem Beton als Parabolrinnen solarthermischer Kraftwerke
Authors: Müller Sören , Forman Patrick , Schnell Jürgen , Mark Peter
Published: November 2013

Parabolrinnen gehören zu solarthermischen Kraftwerken mit Solarstrahlenkonzentration. Die Kollektoren werden derzeit als räumliche Stahlfachwerke mit punktförmig gestützten Spiegeln ausgeführt. Zu diesem Konstruktionsprinzip sind Alternativen möglich. Im Rahmen des Schwerpunktprogramms 1542 “Leicht Bauen mit Beton”, gefördert durch die Deutsche Forschungsgemeinschaft (DFG), wird im Teilprojekt “Leichte verformungsoptimierte Schalentragwerke aus mikrobewehrtem UHPC am Beispiel von Parabolrinnen solarthermischer Kraftwerke” gezeigt, dass Beton wirtschaftliche Konstruktionsvarianten ermöglicht. Im Projekt entstand in Kooperation der Ruhr‐Universität Bochum und der Technischen Universität Kaiserslautern ein Großdemonstrator, der die Bauweise eines solchen Kollektorelements zunächst aus hochfestem Beton vor Augen führt. Die Besonderheit besteht dabei nicht nur in der Verwendung des Werkstoffs Beton, sondern auch in einer neuartigen Auflagerkonstruktion. Anhand von numerischen Untersuchungen werden die Verformungen unter maßgeblichen Einwirkungen für eine großformatige Parabolrinne analysiert. Eine Genauigkeitsanalyse zeigt die Wirksamkeit des Kollektors. Entwurf und Realisierung des Demonstrators sowie Ergebnisse zur rechnerischen Wirksamkeitsbeurteilung sind Inhalt dieses Beitrags.

Lightweight shells made of high‐strength concrete for parabolic troughs in solar power plants – conceptual design and creation of a prototype

Parabolic troughs are a kind of solar power plants that concentrate solar rays. Up to now, these collectors are usually made of spatial steel frame works which support mirrors point‐wise. However, alternative construction principles are feasible. In the framework of priority program 1542 “Concrete light” funded by the German Research Foundation (DFG) subproject “Leichte verformungsoptimierte Schalentragwerke aus mikrobewehrtem UHPC am Beispiel von Parabolrinnen solarthermischer Kraftwerke” demonstrates that alternatives made from concrete can be competitive and even economically beneficial. A first prototype of a lightweight but high‐strength concrete trough has been built in cooperation of Ruhr‐Universität Bochum and Technische Universität Kaiserslautern. Its specific feature is not only the use of concrete instead of steel, but even the novel supporting structure. Based on numerical simulation deflections from significant action effects are analyzed on a true to scale trough structure. An accuracy analysis approved the trough's efficiency. This contribution focusses on the issues design and creation of a first prototype and discusses results on its assessment by numerical efficiency analyses.
Fundamental Beliefs, Origin Explanations and Perceived Effectiveness of Protection Measures: Exploring Laypersons' Chains of Reasoning About Influenza
Authors: Eicher Véronique , Clémence Alain , Bangerter Adrian , Mouton Audrey , Green Eva G. T. , Gilles Ingrid
Published: November 2013

Laypersons' chains of reasoning in explaining recent influenza outbreaks are investigated. Drawing on social representations theory, fundamental worldviews, that is, the belief in a dangerous world (BDW), are postulated to anchor explanations of disease origins, which in turn affect perceived effectiveness of protection measures. Our study, based on a longitudinal survey among the general public in Switzerland, showed that the lower people's BDW scores, the more they appeal to natural origins to explain outbreaks and the more they perceive official protection measures as effective. The higher people's BDW scores, the more they explain outbreaks via hygienic origins, which are linked with out‐group discrimination measures, and conspiracy origins, which are linked with lower perceived effectiveness of aid intervention measures. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis of Cytotoxic Palmerolides
Authors: Lisboa Marilda P. , Dudley Gregory B.
Published: November 2013

The chemical synthesis of the palmerolides is the subject of this review. The palmerolides are a family of Antarctic marine natural products, many of which display potent and selective cytotoxicity against melanoma cells. The confluence of promising bioactivities, limited natural supplies, and complex structures makes the palmerolides exciting targets for chemical synthesis. To date, several approaches have been reported, and a consensus strategy based on convergent fragment assembly has emerged. Collective wisdom from myriad approaches reviewed here may enable hybrid strategies capable of delivering larger amounts of synthetic palmerolides to support continued biological studies. Considering the relative lack of options for melanoma chemotherapy and the intriguing activity profile of the palmerolides, efforts aimed at developing an efficient, gram‐scale synthesis of palmerolide A and congeneric structures should be given a high priority.
Structure‐Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA
Authors: Kadam Rameshwar U. , Bergmann Myriam , Garg Divita , Gabrieli Gabriele , Stocker Achim , Darbre Tamis , Reymond Jean‐Louis
Published: November 2013

The galactopeptide dendrimer GalAG2 ((β‐Gal‐OC6H4CO‐Lys‐Pro‐Leu)4(Lys‐Phe‐Lys‐Ile)2Lys‐His‐Ile‐NH2) binds strongly to the Pseudomonas aeruginosa (PA) lectin LecA, and it inhibits PA biofilms, as well as disperses already established ones. By starting with the crystal structure of the terminal tripeptide moiety GalA‐KPL in complex with LecA, a computational mutagenesis study was carried out on the galactotripeptide to optimize the peptide–lectin interactions. 25 mutants were experimentally evaluated by a hemagglutination inhibition assay, 17 by isothermal titration calorimetry, and 3 by X‐ray crystallography. Two of these tripeptides, GalA‐KPY (dissociation constant (KD)=2.7 μM) and GalA‐KRL (KD=2.7 μM), are among the most potent monovalent LecA ligands reported to date. Dendrimers based on these tripeptide ligands showed improved PA biofilm inhibition and dispersal compared to those of GalAG2, particularly G2KPY ((β‐Gal‐OC6H4CO‐Lys‐Pro‐Tyr)4(Lys‐Phe‐Lys‐Ile)2Lys‐His‐Ile‐NH2). The possibility to retain and even improve the biofilm inhibition in several analogues of GalAG2 suggests that it should be possible to fine‐tune this dendrimer towards therapeutic use by adjusting the pharmacokinetic parameters in addition to the biofilm inhibition through amino acid substitutions.
Solvent‐Induced Helical Assembly and Reversible Chiroptical Switching of Chiral Cyclic‐Dipeptide‐Functionalized Naphthalenediimides
Authors: Manchineella Shivaprasad , Prathyusha V. , Priyakumar U. Deva , Govindaraju T.
Published: November 2013

Understanding the roles of various parameters in orchestrating the preferential chiral molecular organization in supramolecular self‐assembly processes is of great significance in designing novel molecular functional systems. Cyclic dipeptide (CDP) chiral auxiliary‐functionalized naphthalenediimides (NCDPs 1–6) have been prepared and their chiral self‐assembly properties have been investigated. Detailed photophysical and circular dichroism (CD) studies have unveiled the crucial role of the solvent in the chiral aggregation of these NCDPs. NCDPs 1–3 form supramolecular helical assemblies and exhibit remarkable chiroptical switching behaviour (M‐ to P‐type) depending on the solvent composition of HFIP and DMSO. The strong influence of solvent composition on the supramolecular chirality of NCDPs has been further corroborated by concentration and solid‐state thin‐film CD studies. The chiroptical switching between supramolecular aggregates of opposite helicity (M and P) has been found to be reversible, and can be achieved through cycles of solvent removal and redissolution in solvent mixtures of specific composition. The control molecular systems (NCDPs 4–6), with an achiral or D‐isomer second amino acid in the CDP auxiliary, did not show chiral aggregation properties. The substantial roles of hydrogen bonding and π–π interactions in the assembly of the NCDPs have been validated through nuclear magnetic resonance (NMR), photophysical, and computational studies. Quantum chemical calculations at the ab initio, semiempirical, and density functional theory levels have been performed on model systems to understand the stabilities of the right (P‐) and left (M‐) handed helical supramolecular assemblies and the nature of the intermolecular interactions. This study emphasizes the role of CDP chiral auxiliaries on the solvent‐induced helical assembly and reversible chiroptical switching of naphthalenediimides.
ChemInform Abstract: New Ternary Indide La2Pd3In4.
Authors: Nesterenko S. N. , Tursina A. I. , Noel H. , Seropegin Y. D. , Kaczorowski D.
Published: November 2013

La2Pd3In4 is prepared by arc‐melting of the elements.
ChemInform Abstract: The Tetragermanates A2Ge4O9 (A: Na, K and Rb).
Authors: Redhammer Guenther J. , Tippelt Gerold
Published: November 2013

The structures of the isotypic title compounds (trigonal, space group P$\bar 3$c1, Z = 6) are redetermined by single crystal XRD.
ChemInform Abstract: Optical and Structural Investigations on Sb2S2O New Kermesite Alloy for Optoelectronic Applications.
Authors: Lakhdar M. Haj , Larbi T. , Ouni B. , Amlouk M.
Published: November 2013

Sb2S2O thin films are prepared on glass substrates by heat treatment of vapor deposited Sb thin films (100 °C substrate temperature) both in sulfur atmosphere (300 °C, 6 h) and finally in air (350 °C, 6 h).
ChemInform Abstract: Bismuth Phosphate: A Novel Cathode Material Based on Conversion Reaction for Lithium‐Ion Batteries.
Authors: Hu Benan , Wang Xianyou , Wei Qiliang , Shu Hongbo , Yang Xiukang , Bai Yansong , Wu Hao , Song Yunfeng , Liu Li
Published: November 2013

Hexagonal BiPO4 is precipitated from a solution of Bi(NO3)3 in 10 wt.% aq.
ChemInform Abstract: Ca[LiAlN2]: A Quaternary Nitridoaluminate.
Authors: Pust Philipp , Pagano Sandro , Schnick Wolfgang
Published: November 2013

Ca[LiAlN2] is prepared by reaction of LiAlH4, LiN3, and Ca in a lithium flux (weld‐shut Ta crucibles in silica tube, 900 °C, 24 h).
ChemInform Abstract: Synthesis and Characterization of a Soluble Vanadium‐Containing Keggin Polyoxoniobate by ESI‐MS and 51V NMR: (TMA)9 [V3Nb12O42]·18H2O.
Authors: Son Jung‐Ho , Ohlin C. Andre , Larson Emma C. , Yu Ping , Casey William H.
Published: November 2013

The title compound (TMA: tetramethylammonium) is hydrothermally synthesized from a mixture of hydrous Nb2O5 and V2O5 in aqueous Me4NOH solution (autoclave, 110 °C, 86 h, 36% yield).
ChemInform Abstract: Dipotassium Diaquadiphosphatooctaperoxotetramolybdate, [K2(P2O7){MoO (O2)2}2 {MoO(O2)2(OH2)}2]2‐ — A One‐Dimensional Double Chain Array of Polyanions linked by Potassium Cations.
Authors: Aoki Koji , Iwata Keisuke , Iwata Takahiro , Hashimoto Masato
Published: November 2013

The title anion is synthesized by reaction of metallic molybdenum dissolved in H2O2, K4P2O7 and Me4NCl (H2O, 20 °C, 1—2 d; 69% yield).
ChemInform Abstract: Design and Evaluation of Improved Magnetic Stir Bars for Single‐Mode Microwave Reactors.
Authors: Obermayer David , Damm Markus , Kappe C. Oliver
Published: November 2013

A new vertical blade stir bar that improves the stirring performance in flow‐constricting microwave vessels is designed and evaluated for several transformations where stirring and efficient agitation are known to be of importance.
ChemInform Abstract: Synthesis of Cyclobutane Lignans via an Organic Single Electron Oxidant—Electron Relay System.
Authors: Riener Michelle , Nicewicz David A.
Published: November 2013

The photolytic dimerization of methoxy substituted styrenes is studied using an oxopyrylium salt as the catalyst as well as a variety of electron relay additives.
ChemInform Abstract: Rhodium‐Catalyzed Highly Regioselective Hydroaminomethylation of Styrenes with Tetraphosphorus Ligands.
Authors: Li Shengkun , Huang Kexuan , Zhang Jiwen , Wu Wenjun , Zhang Xumu
Published: November 2013

In contrast to other known methods the linear products are predominantly formed by this procedure.
ChemInform Abstract: Highly Efficient Synthesis of Aryl and Heteroaryl Trifluoromethyl Ketones via o‐Iodobenzoic acid (IBX).
Authors: Cheng Huicheng , Pei Yu , Leng Faqiang , Li Jingya , Liang Apeng , Zou Dapeng , Wu Yangjie , Wu Yusheng
Published: November 2013

The coupling of aldehydes (I) and (V) with trimethyl(trifluoromethyl)silane (II) followed by deprotection of intermediate Tms‐protected alcohols affords trifluoromethylated alcohols (III) and (VI), which are readily oxidized with IBX to desired ketones (IV) and (VII) in high yields.
ChemInform Abstract: Methylene‐Bridged Bis(imidazoline)‐Derived 2‐Oxopyrimidinium Salts as Catalysts for Asymmetric Michael Reactions.
Authors: Sheshenev Andrey E. , Boltukhina Ekaterina V. , White Andew J. P. , Hii King Kuok
Published: November 2013

A series of 2‐oxopyrimidinium chlorides is prepared and their utility as chiral catalyst for the asymmetric Michael reaction is demonstrated.
ChemInform Abstract: Synthesis of Functionalized Pseudopeptides Through Five‐Component Sequential Ugi/Nucleophilic Reaction of N‐Substituted 2‐Alkynamides with Hydrazides.
Authors: Maghari Shokoofeh , Ramezanpour Sorour , Balalaie Saeed , Darvish Fatemeh , Rominger Frank , Bijanzadeh Hamid Reza
Published: November 2013

A novel approach for the synthesis of the title compounds containing hydrazones [e.g. (VI)] and vinyl hydrazide (XIV) groups is presented for a broad substrate scope.
ChemInform Abstract: Polymerized Functional Ionic Liquid Supported Pd Nanoparticle Catalyst for Reductive Homocoupling of Aryl Halides.
Authors: Wang Jiayi , Li Yuan , Li Pinzhen , Song Gonghua
Published: November 2013

Aryl iodides and bromides react selectively to the reductive homocoupling products.
ChemInform Abstract: Asymmetric Synthesis of Druglike Six‐Membered Spirooxindoles Through an Amino Enyne Catalysis.
Authors: Ramachary D. B. , Venkaiah Chintalapudi , Madhavachary R.
Published: November 2013

A versatile new method for the room‐temperature synthesis of the title compounds is developed and uses a quinine‐derived organocatalyst.
ChemInform Abstract: Regioselective Ruthenium Catalyzed Hydrohydroxyalkylation of Dienes with 3‐Hydroxy‐2‐oxindoles: Prenylation, Geranylation, and Beyond.
Authors: Chen Te‐Yu , Krische Michael J.
Published: November 2013

A Ru‐catalyst system is presented to allow unique alcohol dehydrogenation and subsequent diene‐carbonyl oxidative C‐C coupling.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Cross‐Coupling of N‐Tosylhydrazones with Indoles: Synthesis of N‐Vinylindoles.
Authors: Zeng Xiaobao , Cheng Guolin , Shen Jinhai , Cui Xiuling
Published: November 2013

The novel title oxidative Pd‐catalyzed cross‐coupling reaction tolerating a wide scope of functional groups is developed.
ChemInform Abstract: Molecular Diversity of Cycloaddition Reactions of the Functionalized Pyridinium Salts with 3‐Phenacylideneoxindoles.
Authors: Fu Qin , Yan Chao‐Guo
Published: November 2013

Deprotonation of pyridinium salts provides pyridinium ylides which undergo Michael addition/cyclization reaction with indole derivatives (I) to form spirocyclic compounds and furanylidene‐oxindoles.
ChemInform Abstract: A Novel Allylic Substitution Strategy to Four‐Component Synthesis of Pyrazole‐Substituted Fused Pyrroles.
Authors: Tu Xing‐Chao , Fan Wei , Jiang Bo , Wang Shu‐Liang , Tu Shu‐Jiang
Published: November 2013

The reaction time over two steps takes ca. 30 min in all cases.
ChemInform Abstract: Novel and Efficient Synthesis of 4,7‐Dihydro‐1H‐pyrrolo[2,3‐b]pyridine Derivatives via One‐Pot, Three‐Component Approach from N‐Substituted 5‐Amino‐3‐cyanopyrroles, Various Carbonyl and Active Methylene Compounds.
Authors: Vilches‐Herrera Marcelo , Spannenberg Anke , Langer Peter , Iaroshenko Viktor O.
Published: November 2013

Simple procedures are presented for the synthesis of in total about 50 novel dihydropyrrolopyridines with fused 4‐spirocyclic frameworks under mild conditions.
ChemInform Abstract: Sequential Reactions of Trimethylsilyldiazomethane with 4‐Alkenyl Ketones and Aldehydes Catalyzed by Lewis Bases.
Authors: Liu Huaqing , O'Connor Matthew J. , Sun Chunrui , Wink Donald J. , Lee Daesung
Published: November 2013

A wide range of novel bi‐ and tricyclic pyrazolines are synthesized via addition of trimethylsilyldiazomethane to aldehydes or ketones, 1,3‐Brook rearrangement, and intramolecular 1,3‐dipolar cycloaddition.
ChemInform Abstract: Reaction of Acylpyruvic Acid Esters with Hydrazides.
Authors: Pakal'nis V. V. , Zerova I. V. , Yakimovich S. I. , Alekseyev V. V.
Published: November 2013

5‐Hydroxy‐2‐pyrazolines are obtained by reaction of hydrazides with acylpyruvic acid esters possessing a terminal straight chain alkyl substituent at the C=O bond distal from the ester group.
ChemInform Abstract: Simple and Efficient Method for the Synthesis of Highly Substituted Imidazoles Catalyzed by Benzotriazole.
Authors: Xu Feng , Wang Nige , Tian Youping , Li Gaoqiang
Published: November 2013

Products (III) and (V) are purified by recrystallization.
ChemInform Abstract: Synthesis, Characterization, and in vitro Antimicrobial Activity of Methyleneamine‐Linked Bis‐heterocycles.
Authors: Babulreddy A. , Hymavathi R. V. , Hussain Md. Manzoor , Swamy G. Narayana
Published: November 2013

Products (III) exhibit antimicrobial activity.
ChemInform Abstract: Synthesis and Biological Evaluation of Some New Polyfluorinated 4‐Thiazolidinone and α‐Aminophosphonic Acid Derivatives.
Authors: Abdel‐Rahman Reda M. , Ali Tarik E.
Published: November 2013

All synthesized compounds are screened for their antifungal activity against Alternaria alternate and Fusarium oxysporium and the enzymatic effects of the cellobiase produced by the fungi are estimated.
ChemInform Abstract: The Inhibitory Effect of a Synthetic Compound, (Z)‐5‐(2,4‐Dihydroxybenzylidene)thiazolidine‐2,4‐dione (MHY498), on Nitric Oxide‐Induced Melanogenesis.
Authors: Chung Hae Young , et al. et al.
Published: November 2013

MHY498 (III) is found to be a promising anti‐melanogenic agent.
ChemInform Abstract: Synthesis of 2,4,5‐Trisubstituted Thiazoles via Lawesson′s Reagent‐Mediated Chemoselective Thionation‐Cyclization of Functionalized Enamides.
Authors: Kumar S. Vijay , Parameshwarappa G. , Ila H.
Published: November 2013

Enamides obtained by ring‐opening of oxazoles either with sodium alkoxides or primary amines, efficiently undergo the title reaction in the presence of Lawesson reagent.
ChemInform Abstract: A Recyclable Ruthenium(II) Complex Supported on Magnetic Nanoparticles: A Regioselective Catalyst for Alkyne—Azide Cycloaddition.
Authors: Wang Dong , Salmon Lionel , Ruiz Jaime , Astruc Didier
Published: November 2013

A magnetically separable Ru‐catalyst is synthesized through immobilizing a pentamethylcyclopentadienyl Ru‐complex on maghemite nanoparticles.
ChemInform Abstract: One‐Pot Preparation of 3‐Chloropiperidine Compounds via Cu(II)‐Promoted Intramolecular Chloroamination of Unfunctionalized Olefins.
Authors: Li Run‐Lin , Liu Gong‐Qing , Li Wei , Wang Yu‐Mei , Li Lin , Duan Lili , Li Yue‐Ming
Published: November 2013

The CuCl2 promoted cyclization of unsaturated amines at room temperature leads to the formation of intermediate pyrrolidine derivatives, which rearrange at elevated temperature to produce piperidines.
ChemInform Abstract: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Quinolone Derivatives as Potential Antitumor Topoisomerase I Inhibitors.
Authors: Shou Kai‐jun , Li Jie , Jin Yi , Lv Yan‐wen
Published: November 2013

N‐substituted piperazinylquinolone derivatives (I) are prepared via a two‐step one‐pot tandem process by reaction of arylsulfonyl chloride with cyanamide and subsequent addition of norfloxacin or ciprofloxacin hydrochloride.
ChemInform Abstract: Novel Synthetic 9‐Benzyloxyacridine Analogue as Both Tyrosine Kinase and Topoisomeras I Inhibitor.
Authors: Lang Xu‐Liang , Sun Qin‐Sheng , Chen Yu‐Zong , Li Lu‐Lu , Tan Chun‐Yan , Liu Hong‐Xia , Gao Chun‐Mei , Jiang Yu‐Yang
Published: November 2013

A series of novel 9‐benzylaminoacridine derivatives (III) and their analogue 9‐benzyloxyacridine (V) are synthesized.
ChemInform Abstract: Synthesis of Benzopyranopyrrolidines via 1,3‐Dipolar Cycloaddition of Nonstabilized Azomethine Ylides with 3‐Substituted Coumarins.
Authors: Moshkin Vladimir S. , Sosnovskikh Vyacheslav Ya. , Roeschenthaler Gerd‐Volker
Published: November 2013

Azomethine ylides generated in situ from amino acids and aldehydes or ketones undergo 1,3‐dipolar cycloadditions with coumarine derivatives to afford benzopyranopyrrolidines.
ChemInform Abstract: Highly Efficient Construction of Pentacyclic Benzo[b]indeno‐[1,2,3‐de][1,8]naphthyridine Derivatives via Four‐Component Domino Reaction.
Authors: Cao Cheng‐Pao , Lin Wei , Hu Ming‐Hua , Huang Zhi‐Bin , Shi Da‐Qing
Published: November 2013

The one‐pot transformation involves the formation of four new C—C and two new C—N bonds, as well as the construction of three new rings with efficient use of all reactants.
ChemInform Abstract: Synthesis and Properties of 6,6‐Di(indol‐3‐yl)indolo[2,1‐b]quinazolin‐12(6H)‐one and Its 2,8‐Dimethyl and 2,8‐Dibromo Derivatives.
Authors: Moskovkina T. V. , Kalinovskii A. I. , Martyyas E. A. , Anisimov M. M.
Published: November 2013

The new tryptanthrin derivative (IIIa) possesses moderate inhibitory activity to C.
ChemInform Abstract: Synthesis of Some New Nitrogen Bridge‐Head Triazolopyridines, Pyridotriazines, and Pyridotriazepines Incorporating 6‐Methylchromone Moiety.
Authors: Abdel‐Megid M. , Ibrahim M. A. , Gabr Y. , El‐Gohary N. M. , Mohamed E. A.
Published: November 2013

All products are purified by recrystallization.
ChemInform Abstract: Reaction of Strongly Electrophilic Alkenylboranes with Phosphanylalkynes: Rare Examples of Intermolecular 1,1‐Alkenylboration Reactions.
Authors: Ekkert Olga , Tuschewitzki Ottmar , Daniliuc Constantin G. , Kehr Gerald , Erker Gerhard
Published: November 2013

The title reaction affords phosphane‐borane Lewis pairs (III) with a conjugated diene backbone.
ChemInform Abstract: Synthesis of New (3‐Fluoroimidazo[1,2‐a]pyridin‐2‐yl)phosphonates
Authors: Aksinenko A. Yu. , Goreva T. V. , Epishina T. A. , Sokolov V. B.
Published: November 2013

by a tandem reaction of imidoyl chlorides (III) with two equivalents of triethyl phosphite
ChemInform Abstract: Synthesis and Reactivity of Dibenzoselenacycloheptynes.
Authors: de Almeida Gabriela , Townsend Lisa C. , Bertozzi Carolyn R.
Published: November 2013

The title compound (VI) is a new type of strained alkyne and is synthesized via a short synthetic route.
ChemInform Abstract: Sesquiterpene Coumarins from Ferula fukanensis and Their Proinflammatory Cytokine Gene Expression Inhibitory Effects.
Authors: Motai Tsunetake , Daikonya Akihiro , Kitanaka Susumu
Published: November 2013

Six novel sesquiterpene coumarin derivatives, fukanefuromarin H‐M, (I)‐(IV), are isolated from the roots of F.fukanensis.
ChemInform Abstract: Triterpenes with Cytotoxicity from the Leaves of Vernicia fordii.
Authors: Pei Yi‐Hua , Kwon Ok‐Kyoung , Lee Ji‐Seon , Cha Hyuk‐Jin , Ahn Kyung‐Seop , Oh Sei‐Ryang , Lee Hyeong‐Kyu , Chin Young‐Won
Published: November 2013

New triterpenes (I) and (II) are isolated from the title plant along with five known triterpenes.
ChemInform Abstract: Two New Bufotoxins from the Skin of Bufo bufo gargarizans
Authors: Li Hai‐Yan , Zhang Lian‐Zhu , Wang Shi‐Hui , Deng Yue , Jin Xiang‐Qun
Published: November 2013

isolation and structure determination of two new bufotoxins, tolocinobufagin‐3‐succinoylarginine ester and tolocinobufagin‐3‐hemisuberate
ChemInform Abstract: A Facile One‐Pot Route for the General Synthesis of Triazole Linked Chiral 2‐Substituted Benzimidazoles.
Authors: Dutta Samrat , Sarkar Swarbhanu , Sen Asish Kumar
Published: November 2013

The fast and plain approach involves copper(I) catalyzed simultaneous formation of benzimidazole and triazole rings.
ChemInform Abstract: New Method of Isolation of Piperine from Piper retrofractum Vahl.
Authors: Pandey Archana , Gupta Ravindra Kumar , Srivastava Santosh Kumar , Agrawal Babita
Published: November 2013

A new method for the isolation of piperine (I) from Piper retrofractum Vahl by methanol/water is described.
ChemInform Abstract: Directly Regioselective Protection of Secondary Hydroxyl Group on Ribosides in Aqueous Solution.
Authors: Xu Ruigang , Liu Fei , Liu Yingju , Chen Beiqing , Liu Feng‐Wu
Published: November 2013

The treatment with benzoyl chloride and Na2CO3 in aqueous acetonitrile allows regioselective benzoylation of secondary hydroxyl moieties in ribosides.
ChemInform Abstract: New Rotenoids and Coumaronochromonoids from the Aerial Part of Boerhaavia erecta.
Authors: Do Thi My Lien , Truong Anh Vu , Pinnock Travis George , Pratt Lawrence Michael , Yamamoto Shigeki , Watarai Hitoshi , Guillaume Dominique , Nguyen Kim Phi Phung
Published: November 2013

Two new coumaronochromanoids, (I) and (III), and three new rotenoids, (II), (IV), and (V), are isolated from the title plant, together with ten known compounds.
ChemInform Abstract: Ultrafast Magnetization Dynamics of Nanostructures
Authors: Bigot Jean‐Yves , Vomir Mircea
Published: November 2013

Review: 122 refs.
ChemInform Abstract: Quantum Criticality and Unconventional Order in Magnetic and Dielectric Material
Authors: Rowley S. , Smith R. , Sutherland M. , Alireza P. , Saxena S. , Lonzarich G.
Published: November 2013

Review: 15 refs.