bluuebunny/crossref_metadata_2025 huggingface dataset:
Robotic-Assisted Thoracoscopic (RATS) Enucleation of Esophageal Mesenchymal Tumors and Foregut Cysts
Authors: Chen Yung-Hsin , Chen Ke-Cheng , Huang Pei-Ming , Kuo Shuenn-Wen , Lin Mong-Wei , Lee Jang-Ming
Published: November 2022

Background: Esophageal mesenchymal tumors and foregut cysts are mostly benign lesions of the esophagus. Tumor enucleation is recommended for lesions with a risk of malignancy, or for the relief of clinical symptoms. Although robotic-assisted thoracoscopic enucleation of esophageal tumors and cysts has been demonstrated in sporadic case reports, its clinical role is yet to be elucidated. Methods: This study aimed to present the first case series in the literature for the perioperative and long-term clinical outcomes of robotic-assisted thoracoscopic enucleation. Results: A total of 19 patients who underwent robotic-assisted thoracoscopic enucleation of esophageal tumors and cysts from 2012 to 2019 were included in the study. The mean tumor/cyst size was 5.5 cm (1.5–22 cm). There were two cases shifting to minimally invasive esophagectomy (10.5%) due to intraoperative pathological confirmation of malignant gastrointestinal stromal tumors with mucosal invasion. Perioperative complication was detected in three (15.8%) cases, without 30-day or surgical mortality. There was no recurrence of tumor or symptoms in all patients during the clinical follow-up period (mean = 35 months). Conclusions: Robotic-assisted thoracoscopic enucleation of esophageal submucosal benign tumors is technically feasible and effective. Given its advantage in overcoming spatial limitations, it can become a widely accepted surgical option for such diseases.
The Influence of Coordinative Skills on the Oral Health of Children and Adolescents in Permanent Dentition
Authors: Kolbow Henrike , Kiess Wieland , Hirsch Christian , Vogel Mandy , Schrock Annett , Elger Wieland
Published: November 2022

Removing dental plaque by using a toothbrush is the most important measure for oral hygiene. The aim of the present study was to estimate the impact of the coordination skills of children and adolescents on their oral health (plaque level, DMF/T: decayed, missing, filled teeth). Within a prospective cohort study, 996 children (10 to 18 years) were examined. The results of three coordination tests from the Motorik Modul (MoMo) were included to evaluate the coordination skills. Other parameters taken into account were age, sex, orthodontic treatment and socioeconomic status (SES). Univariate and various multivariate analyses were performed to evaluate relationships. Better results in precision coordination tests were significantly related to a better oral hygiene (backward balancing: logistic regression OR 0.86, 95%CI: 0.73–0.99, p = 0.051, proportional odds model OR 0.86, 95%CI: 0.75–0.99, p = 0.037; one-leg-stand: logistic regression OR 0.78, 95%CI: 0.63–0.96, p = 0.018, proportional odds model OR 0.77, 95%CI: 0.64–0.92, p = 0.003). Higher scores on one-leg-stand were significantly related to a lower caries prevalence (logistic regression OR 0.81, 95%CI: 0.66–0.99, p = 0.037; Poisson regression exp(ß) 0.82, 95%CI: 0.74–0.91, p < 0.001). Coordination test under a time constraint (jumping side-to-side) showed no significant relation. Oral hygiene was poorer in younger children, boys and low SES. Caries prevalence increased with low SES and increasing age. The present results suggest that oral health is influenced by coordinative skills.
Special Issue: “Pelvic Floor Disorders: State of the Art and Future Perspectives”
Authors: Bodner-Adler Barbara
Published: November 2022

This editorial for the Special Issue “Pelvic Floor Disorders: State of the Art and Future Perspectives” aims to draw attention to the broad field of pelvic floor disorders and serves as an invitation for researchers on a global scaleto share their most recent findings with the urogynecologic community [...]
Quality of Life in COVID-19 Outpatients: A Long-Term Follow-Up Study
Authors: Tarazona Vincent , Kirouchena David , Clerc Pascal , Pinsard-Laventure Florence , Bourrion Bastien
Published: November 2022

Background: The long-term issues faced by COVID-19 survivors remain unclear. Symptoms may persist for several months, even in non-hospitalized patients, probably impacting the quality of life. Objective: To assess the health-related quality of life of outpatients one year after SARS-CoV-2 infection. Design, Settings, and Participants: This prospective multicentre study, conducted in France from February 2020 to February 2022, compared 150 COVID-19 cases (PCR+ and/or CT scan+) and 260 controls (PCR-) selected from a database of four COVID centres. Main outcomes: Health-related quality of life assessed using the EQ-5D-5L scale. Results: COVID-19 outpatients (n = 96) had significantly lower health-related quality of life than controls (n = 81) one year after SARS-CoV-2 infection: the EQ-5D-5L index averaged 0.87 in cases and 0.95 in controls (p = 0.002); the EQ- VAS averaged 78 in cases and 86.7 in controls (p < 0.001). This alteration in quality of life was more intense in the areas of pain or discomfort and daily activities. Conclusions: This study is the first to show an alteration in the quality of life of COVID-19 outpatients after one year. Appropriate guidance and community rehabilitation programs are required for outpatients with persistent symptoms of COVID-19. Research must continue to confirm these results in larger cohorts.
Disseminated Intravascular Coagulation in Sepsis and Associated Factors
Authors: Rinaldi Ikhwan , Sudaryo Mondastri Korib , Prihartono Nurhayati Adnan
Published: November 2022

Background: sepsis is a life-threatening organ dysfunction caused by an excessive host immunological response to infection. The incidence of sepsis is increasing every year, and sepsis is the primary cause of mortality in intensive care units (ICUs). DIC is a coagulopathy syndrome that causes microvascular and macrovascular thrombosis and increases the risk of bleeding due to consumptive coagulopathy. The pathophysiology of DIC in sepsis is complex, and further research is required to investigate the involved mechanisms and risk factors. Method: this study is a prognostic analysis of a retrospective cohort. Samples were patients diagnosed with sepsis and admitted to Cipto Mangunkusumo National General Hospital from January 2016 to October 2022. Research subjects were followed until occurrence of DIC during sepsis or recovery from sepsis. The research subjects were selected from medical records using a consecutive total sampling approach. The inclusion criteria were patients aged ≥18 years old and diagnosed with sepsis according to qSOFA criteria with a score of 2. The exclusion criterion was an incomplete medical record. Bivariate and multivariate logistic regression analyses were performed to determine which independent variables contributed to the incidence of DIC and obtain the odds ratios (ORs). p < 0.05 was considered to indicate a statistically significant difference. Results: a total of 248 patients were included after considering the inclusion and exclusion criteria. Of these, 50 (20.2%) septic patients developed DIC. In the multivariate analysis, albumin ≤2.5 g/dL (OR: 2.363; 95% CI: 1.201–4.649), respiratory infection (OR: 2.414; 95% CI: 1.046–5.571), and antibiotic treatment ≥1 h (OR: 2.181; 95% CI: 1.014–4.689) were associated with DIC development. On the basis of the ROC curve, the area under the curve (AUC) was determined to be 0.705 with 95% CI = (0.631–0.778). Conclusion: in our study, the prevalence of DIC in septic patients was 20.2%. Low albumin, respiratory infection, and antibiotic treatment ≥1 h were found to be risk factors for development of DIC in septic patients.
Effectiveness and Safety of Ustekinumab for Moderate to Severely Active Crohn’s Disease: Results from an Early Access Program in Brazil
Authors: Chebli Julio Maria Fonseca , Parra Rogério Serafim , Flores Cristina , Moraes Antonio Carlos , Nones Rodrigo Bremer , Gomes Tarcia Nogueira Ferreira , Perdomo Ana Maria Bravo , Scapini Gustavo , Zaltman Cyrla
Published: November 2022

This prospective, observational, open-label study aimed to provide access to ustekinumab prior to market authorization and assess its safety and effectiveness in patients with Crohn’s disease (CD) refractory to anti-tumor necrosis factor-α and conventional drugs in Brazil. Patients with a diagnosis of moderate-to-severe active CD for ≥3 months before screening received ustekinumab in a single intravenous induction dose (~6 mg/kg) at week 0, and a 90 mg maintenance dose, subcutaneously, every 8 or 12 weeks, from week 8 through to 80. Serious adverse events (SAE), adverse drug reactions (ADR), clinical response (per CD Activity Index and Harvey Bradshaw Index (HBI) scores), remission (per HBI scores), biomarkers (C-reactive protein (CRP) and fecal calprotectin (FC)) and endoscopic improvement rate over 80 weeks were assessed. Patients with a mean age of 39.9 years were assessed. Discontinuation rate was low (23%) and most adverse events were mild (68.7%). The SAE rate was 21% (mostly infections/infestations or gastrointestinal disorder), and ADR rate was 44%. The CD Activity Index and HBI scores decreased (by 74% and 81%, respectively) with 50% of patients showing normalized CRP and FC, and 63% achieved endoscopic improvement. Ustekinumab was fairly safe, well tolerated and effective in a Brazilian cohort of CD patients.
Absolute Risk and Attributable Fraction of Type-Specific Human Papillomavirus in Cervical Cancer and Precancerous Lesions—A Population-Based Study of 6286 Women in Rural Areas of China
Authors: Li Li , Jiang Mingyue , Li Tingyuan , Yin Jian , Feng Ruimei , Dong Li , Imam Sufia , Cui Jianfeng , Liu Bin , Zhang Xun , Pan Qinjing , Qiao Youlin , Chen Wen
Published: November 2022

Background: To investigate the human papillomavirus (HPV) genotype distribution among the general population and assess the attribution of HPV genotypes targeted by vaccines to protect against cervical lesions theoretically. Methods: Cervical samples were collected from women aged 21 to 64 years old from Inner Mongolia and Shanxi Province in China who had not been vaccinated against HPV. HPV type-specific absolute risk (AR) to classified cervical lesions was calculated and then the attributable fraction (AF) was estimated, together with the combined contributions of the HPV types, targeted by four available HPV vaccines and five HPV vaccines in clinical trials in China to protect against cervical lesions. Results: A total of 6286 women with an average age of 44.1 years ± 8.41 (range: 21–64) participated in the study. The age distribution of 14 HR-HPV and HPV16/18 all showed a ‘U’ shape, which peaked in the ≤25 year-group and >55 year-group. The five most common genotypes were HPV16 (4.3%), HPV52 (4.1%), HPV58 (2.1%), HPV51 (2.1%), and HPV66 (1.7%). The prevalence of HPV types 6 and 11 infections was 1.1% and observed with n significant differences across age stratifications in China. AF to CIN2+ was predominated by HPV 16 with 56.2%, followed by HPV58 (12.0%), HPV52 (8.5%), HPV18 (4.3%), and HPV51 (2.9%). HPV52 and 58 in the prophylactic HPV vaccine would enhance the protection against CIN2+ by approximately 20%. Conclusions: Regarding multi-valent HPV vaccine development in China, the HPV types 16, 52, 58, and 18 should be given priority for their high prevalence at the population level, high AR, notable AF, and high relative risk to high-grade cervical lesions.
On the K-Means Clustering Model for Performance Enhancement of Port State Control
Authors: Hou Zeyu , Yan Ran , Wang Shuaian
Published: November 2022

Nowadays, the concept of port state control is viewed as a safety net to safeguard maritime security, protect the marine environment, and ensure decent working and living circumstances for seafarers on board to a large extent. The ship can be detained for further checking if significant deficiencies are discovered during a port state control inspection. There is much research on this topic, but there have been few studies on the relationship between ship deficiencies and ship detention decisions using unsupervised machine learning artificial intelligence techniques. Although the previous methods or models are feasible for ship detention decisions, they all have shortcomings to some extent, such as large training model errors caused by the imbalance of class labels in the dataset and the fact that the training model cannot comprehensively consider all factors influencing ship detention decision due to the complexity and diversity of the problem. Unsupervised algorithms do not need to label all data in advance, and we can incorporate some fields related to port state control inspection data that can be collected into the model to allow the computer to automatically classify the ships at different risk levels according to relative criteria, e.g., the Tokyo memorandum of understanding, which may result in more objective results, thus eliminating the influence of subjective domain knowledge. It may also have more comprehensive coverage and more information on port state control inspection and decision models. Therefore, this research explores and develops an unsupervised algorithm based on k-means to improve port state control inspection decision-making models using the six-years inspection data from the Tokyo memorandum of understanding. The results show that the accuracy rate is around 50%.
Pediatric Candida Bloodstream Infections Complicated with Mixed and Subsequent Bacteremia: The Clinical Characteristics and Impacts on Outcomes
Authors: Lee Wei-Ju , Hsu Jen-Fu , Chen Yu-Ning , Wang Shao-Hung , Chu Shih-Ming , Huang Hsuan-Rong , Yang Peng-Hong , Fu Ren-Huei , Tsai Ming-Horng
Published: November 2022

Background: Pediatricians face a therapeutic challenge when patients with Candida bloodstream infections (BSIs) simultaneously have positive bacterial culture. We aim to characterize the clinical characteristics of pediatric Candida BSIs complicated with mixed bacteremia and subsequent bacterial infections, risk factors and impacts on outcomes. Methods: All episodes of pediatric Candida BSIs between 2005 and 2020 from a medical center in Taiwan were reviewed. Mixed Candida/bacterial BSIs were defined as isolation of a bacterial pathogen from blood cultures obtained within 48 h before or after the onset of Candida BSI. The clinical features and impacts of mixed Candida/bacterial BSIs were investigated. Results: During the study period, 320 patients with a total of 365 episodes of Candida BSIs were identified and analyzed. Mixed Candida/bacterial BSIs were 35 episodes (9.6%). No significant difference was found between mixed Candida/bacterial BSIs and monomicrobial Candida BSIs in terms of patient demographics, Candida species distributions, most chronic comorbidities or risk factors. Patients with mixed Candida/bacterial BSIs were associated with a significantly higher risk of subsequent bacteremia (51.4% vs. 21.2%, p < 0.001) and a relatively higher candidemia-attributable mortality rate (37.2% vs. 22.4%, p = 0.061) than those with monomicrobial Candida BSIs. Mixed Candida/bacterial BSIs were not an independent risk factor of treatment failure or final mortality according to multivariate logistic regression analyses. Conclusions: The clinical significance of mixed Candida/bacterial BSIs in children included a longer duration of septic symptoms, significantly higher likelihood to have subsequent bacteremia, and relatively higher risk of candidemia attributable mortality.
Cognitive Risk-Assessment and Decision-Making Framework for Increasing in-Vehicle Intelligence
Authors: Dimitrakopoulos George , Politi Elena , Karathanasopoulou Konstantina , Panagiotopoulos Elias , Zographos Theodore
Published: November 2022

The key challenge for future automated driving systems is the need to imitate the intelligence and ability of human drivers, both in terms of driving agility, as well as in their intuitive understanding of the surroundings and dynamics of the vehicle. In this paper a model that utilizes data from different sources coming from vehicular sensor networks is presented. The data is processed in an intelligent manner while integrating knowledge and experience associated with potential and any decision. Moreover, the appropriate directives for the safety of the vehicle as well as alerts in case of upcoming emergencies are provided to the driver. The innovation lies in attributing human-like cognitive capabilities—non-causal reasoning, predictive decision-making, and learning—integrated into the processes for perception and decision-making in safety-critical autonomous use cases. The overall approach is described and formulated, while a heuristic function is proposed for assisting the driver in reaching the appropriate decisions. Comprehensive results from our experiments showcase its efficiency, simplicity, and scalability.
Analysis of Occupant Behaviours in Energy Efficiency Retrofitting Projects
Authors: Maghsoudi Nia Elham , Qian Queena K. , Visscher Henk J.
Published: November 2022

This review of studies into Energy Efficiency Retrofitting (EER) has shown the practice of EER to be a key factor in sustainability regeneration. Thus, the retrofitting practice itself (the way it is organised) has received increasing attention from both practitioners and researchers, and studies are now addressing some issues that are affecting the retrofit level of achievement. Most of the risks which lead to low retrofit development are related to owners. This paper aims highlight the role of the occupants in achieving the goals of EER. It is found that: (a) the early involvement of occupants in the design and construction stage, (b) mutual engagement, and (c) an integral approach that involves the occupants are the key to motivate EER decisions from these same occupants. It follows that this involvement, including the demographic characteristics of the occupants, such as their culture, habits, preferences, awareness towards energy saving and socio-economic factors, are indeed effective in influencing the energy-related behaviours of these occupants. Moreover, other factors, such as space-heating behaviour, presence/absence of the occupants, control level of the equipment and window, and lighting control behaviour, are all effective factors in the energy performance of the buildings. Hence, socio-technical advancements, co-design processes and effective energy efficiency policies are recommended strategies to: (a) improve occupants’ behaviours; and (b) increase their participation in EER projects.
Supply Chain Relationships in Circular Business Models: Supplier Tactics at Royal Smit Transformers
Authors: van Tilburg Marlies , Krikke Harold , Lambrechts Wim
Published: November 2022

Background: Despite growing popularity, Circular Economy has not reached its full potential. One of the frequently mentioned success factors is the adoption of a Circular Business Model. However, fueled by (too) many constraints, its implementation is often hampered by so-called vicious cycles. Successful Circular Business Models require intensive collaboration between buyers and suppliers, with one of the key questions remaining who takes the initiative and leads the development: buyer or supplier? Methods: Through a single case study combining desk research, interviews, participative observations and analysis of vicious cycles, we investigate how supply chain relationships managed by the supplier can enhance the implementation of Circular Business Models. Results: We show that supplier tactics can relax constraints and break vicious cycles through (1) buyer–supplier relationship management, (2) functional integration of stakeholders and (3) incentive management. We also show that, due to supplier captive conditions, a number of enabling factors are indispensable, namely: (1) the availability of buyer incentives; (2) (joint experimenting to develop) circular knowledge; (3) sharing clear visions on circularity; (4) being transparent in possibilities; and (5) supply chain leadership. Conclusions: As a consequence, strategic trust-based partnerships are a prerequisite for turning vicious cycles into virtuous cycles. Future research should also investigate the role of the buyer, including buyer captive conditions, and how to shape supply chain leadership. Finally, the role of supplier tactics in relation to other success factors next to Circular Business Models needs to be further explored.
Correlations on the Structure and Properties of Collagen Hydrogels Produced by E-Beam Crosslinking
Authors: Demeter Maria , Călina Ion , Scărișoreanu Anca , Micutz Marin , Kaya Mădălina Albu
Published: November 2022

In this study, a collagen hydrogel using collagen exclusively produced in Romania, was obtained by electron beam (e-beam) crosslinking. The purpose of our study is to obtain new experimental data on the crosslinking of collagen and to predict as faithfully as possible, its behavior at high irradiation doses and energies. To pursue this, the correlations between macromolecular structure and properties of collagen hydrogels were determined by rheological analysis, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Differential Scanning Calorimetry (DSC), respectively. The gel fraction, swelling degree, and network parameters of the collagen hydrogels were also investigated at different irradiation doses. Through experimental exploration, we concluded that irradiation with e-beam up to 25 kGy induces crosslinking processes in collagen structure without producing advanced degradation processes. E-beam technology is a great method to develop new materials for medical applications without adding other chemical reagents harmful to human health. The future aim is to develop new wound dressings for rapid healing based on collagen, through irradiation technologies.
Influence of TiO2 and ZnO Nanoparticles on α-Synuclein and β-Amyloid Aggregation and Formation of Protein Fibrils
Authors: Slekiene Nora , Snitka Valentinas , Bruzaite Ingrida , Ramanavicius Arunas
Published: November 2022

The most common neurological disorders, i.e., Parkinson’s disease (PD) and Alzheimer’s disease (AD), are characterized by degeneration of cognitive functions due to the loss of neurons in the central nervous system. The aggregation of amyloid proteins is an important pathological feature of neurological disorders.The aggregation process involves a series of complex structural transitions from monomeric to the formation of fibrils. Despite its potential importance in understanding the pathobiology of PD and AD diseases, the details of the aggregation process are still unclear. Nanoparticles (NPs) absorbed by the human circulatory system can interact with amyloid proteins in the human brain and cause PD. In this work, we report the study of the interaction between TiO2 nanoparticles (TiO2-NPs) and ZnO nanoparticles (ZnO-NPs) on the aggregation kinetics of β-amyloid fragment 1-40 (βA) and α-synuclein protein using surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS). The characterizations of ZnO-NPs and TiO2-NPs were evaluated by X-ray diffraction (XRD) spectrum, atomic force microscopy (AFM), and UV-Vis spectroscopy. The interaction of nanoparticles with amyloid proteins was investigated by SERS. Our study showed that exposure of amyloid protein molecules to TiO2-NPs and ZnO-NPs after incubation at 37 °C caused morphological changes and stimulated aggregation and fibrillation. In addition, significant differences in the intensity and location of active Raman frequencies in the amide I domain were found. The principal component analysis (PCA) results show that the effect of NPs after incubation at 4 °C does not cause changes in βA structure.
Experimental Fatigue Evaluation of Bogie Frames on Metro Trains
Authors: Zhou Wei , Zhang Gangli , Wang Hui , Peng Chang , Liu Xiang , Xiao Heting , Liang Xifeng
Published: November 2022

Metro vehicles have always been known for their high passenger density, frequent traffic flow and strong alternating loads due to their severe running environment. As the major support component, the bogie frame suffers from fatigue damages and receives a high intensity of interest. In this work, a theoretical model is presented between the measured strain and the structural stress via multiple load identification, wherein recognition matrices and stress evaluations of the bogie frame are defined according to the locations found in finite element analysis (FEA). The model is validated through random loading in FE simulation, and the load deviation is within 1.1 kN. A vehicle experiment was performed on the second bogie of the head car on a six-car metro train. The signed von Mises (SVM) stress was calculated at critical locations with the proposed method and compared with what was measured. The excessive part was no more than 14.97%, comparing the reconstructed with the measured amounts. Stress spectra were developed utilizing rain-flow counting and evaluated in terms of the damage accumulation rule with the optimal spectra groups determined from convergence analysis. The evaluation indicates that, when the running mileage increases to the full life cycle of 3,960,000 km, the maximum equivalent damage reaches 0.35 and 0.46 at the gear box base for measured and reconstructed amounts, respectively. Research outcomes suggest that the proposed method offers an alternative for fatigue assessment and maintenance strategies on metro vehicles, as well as other types of rail-transit vehicles.
FeaSel-Net: A Recursive Feature Selection Callback in Neural Networks
Authors: Fischer Felix , Birk Alexander , Somers Peter , Frenner Karsten , Tarín Cristina , Herkommer Alois
Published: November 2022

Selecting only the relevant subsets from all gathered data has never been as challenging as it is in these times of big data and sensor fusion. Multiple complementary methods have emerged for the observation of similar phenomena; oftentimes, many of these techniques are superimposed in order to make the best possible decisions. A pathologist, for example, uses microscopic and spectroscopic techniques to discriminate between healthy and cancerous tissue. Especially in the field of spectroscopy in medicine, an immense number of frequencies are recorded and appropriately sized datasets are rarely acquired due to the time-intensive measurements and the lack of patients. In order to cope with the curse of dimensionality in machine learning, it is necessary to reduce the overhead from irrelevant or redundant features. In this article, we propose a feature selection callback algorithm (FeaSel-Net) that can be embedded in deep neural networks. It recursively prunes the input nodes after the optimizer in the neural network achieves satisfying results. We demonstrate the performance of the feature selection algorithm on different publicly available datasets and compare it to existing feature selection methods. Our algorithm combines the advantages of neural networks’ nonlinear learning ability and the embedding of the feature selection algorithm into the actual classifier optimization.
FAS-UNet: A Novel FAS-Driven UNet to Learn Variational Image Segmentation
Authors: Zhu Hui , Shu Shi , Zhang Jianping
Published: November 2022

Solving variational image segmentation problems with hidden physics is often expensive and requires different algorithms and manually tuned model parameters. The deep learning methods based on the UNet structure have obtained outstanding performances in many different medical image segmentation tasks, but designing such networks requires many parameters and training data, which are not always available for practical problems. In this paper, inspired by the traditional multiphase convexity Mumford–Shah variational model and full approximation scheme (FAS) solving the nonlinear systems, we propose a novel variational-model-informed network (FAS-UNet), which exploits the model and algorithm priors to extract the multiscale features. The proposed model-informed network integrates image data and mathematical models and implements them through learning a few convolution kernels. Based on the variational theory and FAS algorithm, we first design a feature extraction sub-network (FAS-Solution module) to solve the model-driven nonlinear systems, where a skip-connection is employed to fuse the multiscale features. Secondly, we further design a convolutional block to fuse the extracted features from the previous stage, resulting in the final segmentation possibility. Experimental results on three different medical image segmentation tasks show that the proposed FAS-UNet is very competitive with other state-of-the-art methods in the qualitative, quantitative, and model complexity evaluations. Moreover, it may also be possible to train specialized network architectures that automatically satisfy some of the mathematical and physical laws in other image problems for better accuracy, faster training, and improved generalization.
Iron Deficiency in Patients with Advanced Heart Failure
Authors: Bakosova Maria , Krejci Jan , Godava Julius , Ozabalova Eva , Poloczkova Hana , Honek Tomas , Hude Peter , Machal Jan , Bedanova Helena , Nemec Petr , Spinarova Lenka
Published: November 2022

Background and Objectives: Iron deficiency (ID) is a common comorbidity in patients with heart failure. It is associated with reduced physical performance, frequent hospitalisations for heart failure decompensation, and high cardiovascular and overall mortality. The aim was to determine the prevalence of ID in patients with advanced heart failure on the waiting list for heart transplantation. Methods and Materials: We included 52 patients placed on the waiting list for heart transplantation in 2021 at our centre. The cohort included seven patients with LVAD (left ventricle assist device) as a bridge to transplantation implanted before the time of results collection. In addition to standard tests, the parameters of iron metabolism were monitored. ID was defined as a ferritin value <100 µg/L, or 100–299 µg/L if transferrin saturation (T-sat) is <20%. Results: ID was present in 79% of all subjects, but only in 35% of these patients anaemia was expressed. In the group without LVAD, ID was present in 82%, a median (lower–upper quartile) of ferritin level was 95.4 (62.2–152.1) µg/mL and mean T-sat was 0.18 ± 0.09. In LVAD group, ID was present in 57%, ferritin level was 268 (106–368) µg/mL and mean T-sat was 0.14 ± 0.04. Haemoglobin concentration was the same in patients with or without ID (133 ± 16) vs. (133 ± 23). ID was not associated with anaemia defined with regard to patient’s gender. In 40.5% of cases, iron deficiency was accompanied by chronic renal insufficiency, compared to 12.5% of the patients without ID. In the patients with LVAD, ID was present in four out of seven patients, but the group was too small for reliable statistical testing due to low statistical power. Conclusions: ID was present in the majority of patients with advanced heart failure and was not always accompanied by anaemia and renal insufficiency. Research on optimal markers for the diagnosis of iron deficiency, especially for specific groups of patients with heart failure, is still ongoing.
Clinical Validation of Dental Implant Stability by Newly Designed Damping Capacity Assessment Device during the Healing Period
Authors: Lim Ho-Kyung , Lee Sung-Jae , Jeong Yujin , Lee Jong-Seok , Ryu Jae-Jun , Shim Ji-Suk , Song In-Seok
Published: November 2022

Background and Objectives: To evaluate the stability of a dental implant and the effectiveness of a newly designed damping capacity assessment device by improving the number of blows and strength evaluated by a prospective clinical study. Materials and Method: The stability of dental implants was measured in 50 implants in a total of 38 patients. Measurements were performed using Anycheck and Periotest M devices, twice in total, divided into buccal and lingual directions. In addition, measurements were performed on the day of surgery, two weeks, one month, two months, and three months after surgery for a total of five times. After the standardization of the measured values, the differences and changes over time for each device were observed. Result: No difference in standardized values between the two devices was observed at any time point. In both devices, stability decreased at two weeks postoperatively but gradually increased thereafter. No differences were observed in the values according to the measurement direction. Conclusions: The damping capacity of Anycheck was similar to that of Periotest M. After a slight decrease in stability two weeks after implant placement, implant stability increased over time.
Clinical Significance of Lipid Transport Function of ABC Transporters in the Innate Immune System
Authors: Kotlyarov Stanislav , Kotlyarova Anna
Published: November 2022

ABC transporters are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes. It is of interest to note that many ABC transporters are involved in the transport of various lipids. In addition, this function may be related to the innate immune system. The evidence that ABC transporters are involved in the regulation of the innate immune system through the transport of various substances greatly enhances the understanding of their clinical significance. ABC transporters are involved in the cellular homeostasis of cholesterol as well as in the regulation of its content in lipid rafts. Through these mechanisms, they can regulate the function of membrane proteins, including receptors of the innate immune system. By regulating lipid transport, some members of ABC transporters are involved in phagocytosis. In addition, ABC transporters are involved in the transport of lipopolysaccharide, lipid mediators of inflammation, and perform other functions in the innate immune system.
Phase Stability and Mechanical Properties Analysis of AlCoxCrFeNi HEAs Based on First Principles
Authors: Liang Fu , Du Jin , Su Guosheng , Xu Chonghai , Zhang Chongyan , Kong Xiangmin
Published: November 2022

With the in-depth research on high-entropy alloys (HEAs), most of the current research uses experimental methods to verify the effects of the main elements of HEAs on the mechanical properties of the alloys. However, this is limited by the long experimental period and the influence of many external factors. The computer simulation method can not only effectively save costs and shorten the test cycle, but also help to discover new materials and broaden the field of materials. Therefore, in this paper, the physical properties (such as lattice constant, density and elastic constant) of AlCoxCrFeNi (x = 0, 0.25, 0.5, 0.75, 1) HEAs were calculated based on the first-principles calculation method and virtual crystal approximate modeling method. It is found that AlCoxCrFeNi HEAs have the best hardness and toughness properties, with a Co content of 0.5~0.7. The research results can provide theoretical guidance for the preparation of HEAs with optimal mechanical properties.
Enhancement of Cadmium Phytoremediation Potential of Helianthus annuus L. with Application of EDTA and IAA
Authors: Shah Naila , Qadir Muhammad , Irshad Muhammad , Hussain Anwar , Hamayun Muhammad , Murad Waheed , Khan Ajmal , Al-Harrasi Ahmed
Published: November 2022

The aim of the current study was to assess the cadmium (Cd) phytoremediation potential of Helianthus annuus L. that was exposed to 50, 100, and 150 mg/kg of cadmium for 15, 30, and 60 days with application of EDTA (Ethylenediaminetetraacetic acid) in the soil and IAA (indole acetic acid) as a foliar spray. The results indicated that the concentration, duration of exposure, and amount of Cd affect the phytoremediation potential. The maximum Cd was observed at 60 days (32.05, 16.86, and 10.63%) of Cd application, compared to 15 (2.04, 0.60, and 1.17%) or 30 days (8.41, 3.93, and 4.20%, respectively), in a dose-dependent manner. The application of EDTA in the soil and foliar IAA enhanced the Cd accumulation in the plants at 15, 30, and 60 days of exposure, with maximum accumulation at 60 days. Exposed plants with foliar IAA application showed 64.82%, 33.77%, and 25.84% absorption at 50, 100, and 150 mg/kg, respectively. Apart from higher absorption, the cadmium translocation to the edible part of the plants ceased, i.e., the seeds had 0% accumulation. The interesting fact was recorded that efficient phytoremediation was recorded at 15 days of exposure, whereas maximum phytoremediation was recorded at 60 days of exposure. To minimize the stress, the host also produced stress-related metabolites (i.e., flavonoids, phenolics, proline, and sugar) and antioxidants (i.e., catalases and ascorbate peroxidases). From the current evidence, it could be assumed that the use of EDTA and IAA, along with hyperaccumulating plants, could be a possible green method to remediate Cd-contaminated soil efficiently in a short period of time.
Antimicrobial and Antivirulence Activities of Carvacrol against Pathogenic Aeromonas hydrophila
Authors: Wang Junwei , Qin Ting , Chen Kai , Pan Liangkun , Xie Jun , Xi Bingwen
Published: November 2022

Aeromonas hydrophila is a ubiquitous Gram-negative opportunistic pathogen in the freshwater environment and the most common cause of bacterial septicemia in aquaculture. In this study, we investigated the impact of carvacrol, a natural monoterpenoid found in herbs, on the virulence of A. hydrophila in vitro and the antibacterial effect in combination with antibiotics. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of carvacrol against A. hydrophila NJ-35 were 125 µg/mL and 250 µg/mL, respectively. Carvacrol could inhibit the virulence factors (biofilm, protease, exopolysaccharide, and hemolysin) of A. hydrophila, and the antibiofilm potential of carvacrol was further verified by microscopic detection. Transcriptional analyses showed that the gene expression of flaB, ompA, aha, ahp, ela, act, aerA, AhyR, and hly were marked as downregulated. The checkerboard assay results showed that carvacrol did not have an antagonistic effect in combination with antibiotics (florfenicol, enrofloxacin, thiamphenicol, or doxycycline hydrochloride) commonly used in aquaculture but possessed an additive-synergistic effect with neomycin sulfate. In vivo studies demonstrated that carvacrol protected grass carp (Ctenopharyngodon idella) from A. hydrophila infection. Our results indicated that carvacrol possessed significant anti-bacterial and anti-virulence effects on A. hydrophila.
Microfibers: Environmental Problems and Textile Solutions
Authors: Weis Judith S. , De Falco Francesca
Published: November 2022

Microplastics have become a topic of considerable concern and intensive study over the past decade. They have been found everywhere in the oceans, including the deepest trenches and remotest parts of the Arctic. They are ingested by many animals and some are incorporated into tissues. There is considerable effort in studying what effects they have on marine life. It has become clear that when water samples are collected in ways that prevent most long thin particles from escaping through pores of a net, the most abundant type of microplastics found in water and sediments are microfibers (fibers with dimensions less than 5 mm). The major source of these pollutants is synthetic textiles, such as polyester or polyamides, which shed microfibers during their entire life cycle. Microfibers are released during textile manufacturing, everyday activities (e.g., washing, drying, wearing) and final disposal. The complexity of microfiber release mechanisms and of the factors involved make the identification and application of ways to reduce the inputs of microfibers very challenging. A comprehensive approach is strongly needed, taking into account solutions at a number of levels, such as re-engineering textiles to minimize shedding, applying washing machine filters, developing advanced wastewater treatment plants and improving the management of textile wastes. To harmonize and make mandatory the solutions identified, a variety of potential government policies and regulations is also needed.
Hierarchical Multiple-Point Geostatistical Modeling Method and Application Based on Braided River Reservoir Architecture
Authors: Dou Mengjiao , Li Shaohua , Lei Tao , Ren Guanglei , Li Xiaohui , Guo Ying , Feng Wenjie , Zhang Xianghui
Published: November 2022

The Lower Shihezi Formation of the Daniudi gas field in the Ordos Basin is a typical reservoir of a braided river system in an alluvial plain, characterized by extensive braided river development, parallel development from the near source to the center of the basin, and frequent interweaving and cut stacking, as well as a complex deposition process that has seen frequent river channel changes. The braided river belt, braided channel, channel bar inside the river, and interlayer within the channel bar constitute a hierarchical and complicated architectural feature, which poses a great challenge to accurately characterize this type of reservoir for modeling. We proposed a hierarchical, level-by-level embedding, and progressive multiple-point geostatistical modeling strategy that is refined layer by layer according to a 5–3 level architectural unit hierarchy, with the modeling results of each level providing constraints for the next level modeling. The hierarchical geological model based on the combination of qualitative architectural anatomy and quantitative pre-architecture unit scale is critical in guiding the efficient development of the remaining gas in the braided river reservoir in Daniudi.
Portable Non-Destructive Magnetic Resonance Sensor for Assessing the Aging Status of Silicon Rubber Insulators
Authors: Guo Pan , Wang Liling , Wang Rui , Li Bing , Zhao Zhirui
Published: November 2022

Silicone rubber insulators (SRIs) are widely used in high-voltage power grids. Due to high-voltage fields and harsh environmental conditions, SRIs eventually deteriorate with use in the power grid, decreasing their insulating performance and operational life and contributing to transmission line failures. Therefore, quantitatively assessing the aging status of SRIs is crucial. In this study, we evaluated the viability of the magnetic resonance method for assessing the age of SRIs at the level of chemical structure; we built and made a portable magnetic resonance sensor, and evaluated the sensor’s functionality. By measuring the SRI sheds at various service times, it was discovered that the equivalent transverse relaxation time, T2eff, can describe the degree of aging of the SRIs. The results of the magnetic resonance measurements were also compared with those of the static contact angle method, and the two measurement methods yielded the same conclusions. However, the magnetic resonance method was more sensitive than the one using the static contact angle method.
Fe3+/Mn2+ (Oxy)Hydroxide Nanoparticles Loaded onto Muscovite/Zeolite Composites (Powder, Pellets and Monoliths): Phosphate Carriers from Urban Wastewater to Soil
Authors: Guaya Diana , Maza Luz , Angamarca Adriana , Mendoza Eda , García Luis , Valderrama César , Cortina José Luis
Published: November 2022

The development of an efficient adsorbent is required in tertiary wastewater treatment stages to reduce the phosphate–phosphorous content within regulatory levels (1 mg L−1 total phosphorous). In this study, a natural muscovite was used for the preparation of muscovite/zeolite composites and the incorporation of Fe3+/Mn2+ (oxy)hydroxide nanoparticles for the recovery of phosphate from synthetic wastewater. The raw muscovite MC and the obtained muscovite/sodalite composite LMC were used in the powder form for the phosphate adsorption in batch mode. A muscovite/analcime composite was obtained in the pellets PLMCT3 and monolith SLMCT2 forms for the evaluation in fixed-bed mode for continuous operation. The effect of pH, equilibrium and kinetic parameters on phosphate adsorption and its further reuse in sorption–desorption cycles were determined. The characterization of the adsorbents determined the Fe3+ and Mn2+ incorporation into the muscovite/zeolite composite’s structure followed the occupancy of the extra-framework octahedral and in the framework tetrahedral sites, precipitation and inner sphere complexation. The adsorbents used in this study (MC, LMC, PLMCT3 and SLMCT2) were effective for the phosphate recovery without pH adjustment requirements for real treated wastewater. Physical (e.g., electrostatic attraction) and chemical (complexation reactions) adsorption occurred between the protonated Fe3+/Mn2+ (oxy)hydroxy groups and phosphate anions. Higher ratios of adsorption capacities were obtained by powder materials (MC and LMC) than the pellets and monoliths forms (PLMCT3 and SLMCT2). The equilibrium adsorption of phosphate was reached within 30 min for powder forms (MC and LMC) and 150 min for pellets and monoliths forms (PLMCT3 and SLMCT2); because the phosphate adsorption was governed by the diffusion through the internal pores. The adsorbents used in this study can be applied for phosphate recovery from wastewater treatment plants in batch or fixed-bed mode with limited reusability. However, they have the edge of environmentally friendly final disposal being promissory materials for soil amendment applications.
Role of Interdiffusion and Segregation during the Life of Indium Gallium Arsenide Quantum Dots, from Cradle to Grave
Authors: Walther Thomas
Published: November 2022

This article summarizes our understanding of the interplay between diffusion and segregation during epitaxial growth of InGaAs and InAs quantum dots. These quantum dots form spontaneously on flat GaAs (001) single-crystalline substrates by the so-called Stranski-Krastanow growth mechanism once a sufficient amount of indium has accumulated on the surface. Initially a perfectly flat wetting layer is formed. This strained layer then starts to roughen as strain increases, leading first to small, long-range surface undulations and then to tiny coherent islands. These continue to grow, accumulating indium both from the underlying wetting layer by lateral indium segregation and from within these islands by vertical segregation, which for InGaAs deposition results in an indium-enriched InGaAs alloy in the centre of the quantum dots. For pure InAs deposition, interdiffusion also results in an InGaAs alloy. Further deposition can lead to the formation of misfit dislocations that nucleate at the edges of the islands and are generally sought to be avoided. Overgrowth by GaAs or InGaAs alloys with low indium content commences preferentially between the islands, avoiding their strained edges, which initially leads to trench formation. Further deposition is necessary to cap these quantum dots effectively and to re-gain an almost flat surface that can then be used for subsequent deposition of multiple layers of quantum dots as needed for many optoelectronic devices.
Dual Tunable Electromagnetically Induced Transparency Based on a Grating-Assisted Double-Layer Graphene Hybrid Structure at Terahertz Frequencies
Authors: Zhong Xu , Wu Tiesheng , Liu Zhihui , Yang Dan , Yang Zuning , Liu Rui , Liu Yan , Wang Junyi
Published: November 2022

We propose a graphene plasmonic structure by applying two graphene layers mingled with a thin gold layer in a silicon grating. By utilizing the finite-difference time-domain (FDTD) method, we investigate the optical response of the system, and observe that the design achieves dual tunable electromagnetically induced transparency (EIT)-like effect at terahertz frequencies. The EIT-like effect arises from the destructive interference between the grapheme-layer bright modes and the gold-layer dark mode. The EIT-like phenomenon can be adjusted by the Fermi level, which is related to the applied voltage. The results show that the group delay of the present structure reaches 0.62 ps in the terahertz band, the group refractive index exceeds 1200, the maximum delay-bandwidth product is 0.972, and the EIT-like peak frequency transmittance is up to 0.89. This indicates that the device has good slow light performance. The proposed structure might enable promising applications in slow-light devices.