bluuebunny/crossref_metadata_2025 huggingface dataset:
High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus
Authors: Chen Wenwen , Xie Hailun , Xiao Ming , Li Ming , Tang Yi , Zhang Shuxian , Li Xiujun , Wang Yalan
Published: November 2023

Background: Patients with type 2 diabetes mellitus have a higher susceptibility for colorectal cancer and poorer prognosis, but the mechanism is still unknown. Here, we investigated the effect of ADP-ribosyltransferase 1 (ART1) on the growth of colorectal cancer in an animal model of diabetes with high norepinephrine status, as well as the potential mechanism. Methods: We evaluated the size and weight of transplanted CT26 cell tumors with different ART1 expression levels in a mouse model of diabetes, as well as the survival time. CCK8 and flow cytometry were used to evaluate the growth of CT26 cells in vitro. Western blot was performed to analyze differentially expressed proteins in the ART1-modulated pathway. Results: High levels of norepinephrine and ART1 favored the proliferation of CT26 cells in vitro and in vivo. Moreover, inhibition of norepinephrine-dependent proliferation was observed in ART1-silenced CT26 cells compared to those with normal ART1 expression. Following reduction of the serum norepinephrine level by surgery, the size and weight of transplanted CT26 cell tumors was significantly reduced compared to non-operated and sham-operated mice. Furthermore, the expression of ART1, mTOR, STAT3, and p-AKT protein in the tumor tissue of diabetic mice was higher than in non-diabetic mice. Following reduction of the norepinephrine level by renal denervation (RD), expression of the proliferation-related proteins mTOR, STAT3, p-AKT protein decreased, but no change was seen for ART1 expression. At the same concentration of norepinephrine, ART1 induced the expression of p-AKT, mTOR, STAT3, CyclinD1 and c-myc in CT26 cells in vitro. Conclusions: We conclude that faster growth of colorectal cancer in high norepinephrine conditions requires the expression of ART1, and that high ART1 expression may be a novel target for the treatment of diabetes-associated colorectal cancer.
Serum BLMH and CKM as Potential Biomarkers for Predicting Therapeutic Effects of Deep Brain Stimulation in Parkinson's Disease: A Proteomics Study
Authors: Gong Yan , Qian Surong , Chen Dongdong , Ye Ming , Wu Jian , Wang Ya-li
Published: November 2023

Background: Deep brain stimulation (DBS) is recommended for the treatment of advanced Parkinson’s disease (PD), though individual reactions may be different. There are currently no clinically available biomarkers for predicting the responses of PD patients to DBS before surgery. This study aimed to determine serum biomarkers to predict DBS responses in PD. Methods: We profiled differentially expressed proteins (DEPs) in serum samples and identified potential biomarkers to predict the therapeutic responses to DBS in PD patients. Ten serum samples were selected from PD patients to identify DEPs via mass spectrometry proteomics; these were then verified by enzyme-linked immunosorbent assay in another 21 serum samples of PD patients. Results: The present study identified 14 DEPs (10 downregulated and four upregulated DEPs) with significantly different levels between non-responders and responders. Most of the DEPs were related to amino acid metabolism and protein modification pathways. Bleomycin hydrolase (BLMH) and creatine kinase M-type (CKM) were found to be significantly downregulated in the responders. Additionally, subsequent logistic regression and receiver operating characteristic analyses were performed to determine the diagnostic performance of candidate proteins. Conclusions: The identified DEPs show potential as biomarkers for the accurate evaluation of DBS therapeutic responses before surgery. Furthermore, assessment of serum BLMH and CKM may be particularly useful for predicting the therapeutic responses to DBS in PD patients.
Development of a Nomogram Based on Diffusion-Weighted Imaging and Clinical Information to Predict Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
Authors: Wang Shenghai , Han Wenxuan , Sun Tianze , Wang Hui , Zhang Zhenxian , Li Haining
Published: November 2023

Background: Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a severe complication that can arise from acute carbon monoxide poisoning (ACOP). This study aims to identify the independent risk factors associated with DEACMP and to develop a nomogram to predict the probability of developing DEACMP. Methods: The data of patients diagnosed with ACOP between September 2015 and June 2021 were analyzed retrospectively. The patients were divided into the two groups: the DEACMP group and the non-DEACMP group. Univariate analysis and multivariate logistic regression analysis were conducted to identify the independent risk factors for DEACMP. Subsequently, a nomogram was constructed to predict the probability of DEACMP. Results: The study included 122 patients, out of whom 30 (24.6%) developed DEACMP. The multivariate logistic regression analysis revealed that acute high-signal lesions on diffusion-weighted imaging (DWI), duration of carbon monoxide (CO) exposure, and Glasgow Coma Scale (GCS) score were independent risk factors for DEACMP (Odds Ratio = 6.230, 1.323, 0.714, p < 0.05). Based on these indicators, a predictive nomogram was constructed. Conclusions: This study constructed a nomogram for predicting DEACMP using high-signal lesions on DWI and clinical indicators. The nomogram may serve as a dependable tool to differentiate high-risk patients and enable the provision of personalized treatment to lower the incidence of DEACMP.
Plastic Spinal Motor Circuits in Health and Disease
Authors: Windhorst Uwe , Dibaj Payam
Published: November 2023

In the past, the spinal cord was considered a hard-wired network responsible for spinal reflexes and a conduit for long-range connections. This view has changed dramatically over the past few decades. It is now recognized as a plastic structure that has the potential to adapt to changing environments. While such changes occur under physiological conditions, the most dramatic alterations take place in response to pathological events. Many of the changes that occur following such pathological events are maladaptive, but some appear to help adapt to the new conditions. Although a number of studies have been devoted to elucidating the underlying mechanisms, in humans and animal models, the etiology and pathophysiology of various diseases impacting the spinal cord are still not well understood. In this review, we summarize current understanding and outstanding challenges for a number of diseases, including spinal muscular atrophy (SMA), amyotrophic laterals sclerosis (ALS), and spinal cord injury (SCI), with occasional relations to stroke. In particular, we focus on changes resulting from SCI (and stroke), and various influencing factors such as cause, site and extent of the afflicted damage.
Predictors of Low Voltage Zone and Sex Differences in Low Voltage Zone Distribution in Patients with Atrial Fibrillation
Authors: Xin Yu , Hang Fei , Wu Yongquan
Published: November 2023

Background: Previous studies have revealed the left atrial (LA) low voltage zone (LVZ) are tightly linked to the recurrence of atrial fibrillation (AF). Furthermore ablation that targets the LA LVZ can improve patient prognosis. The aim of this study was to identify potential clinical predictors of the LA LVZ, to investigate possible sex differences in the distribution of LA LVZ, and to examine the relationship between LA LVZ and AF recurrence. Methods: A total of 108 patients who underwent AF catheter ablation and LA high-density electro-anatomic mapping were enrolled in the study. Of these, 56 patients with LA LVZ ≥5% were assigned to the LVZ group, while the remaining 52 patients with LA LVZ <5% were assigned to the non-LVZ group. Clinical characteristics and laboratory results for all patients were collected and compared between the two groups. Results: Multivariate logistic regression analysis revealed that persistent AF (odds ratio [OR] = 4.563, 95% confidence interval [CI]: 1.194–17.431, p = 0.026), left atrial volume (LAV, OR = 1.030, 95% CI: 1.001–1.061, p = 0.044) and brain natriuretic peptide (BNP, OR = 1.010, 95% CI: 1.002–1.019, p = 0.015) were independent predictors for the presence of LA LVZ. In addition, female sex (OR = 7.161, 95% CI: 1.518–33.792, p = 0.013), LAV (OR = 1.028, 95% CI: 1.002–1.055, p = 0.035) and BNP (OR = 1.009, 95% CI: 1.001–1.016, p = 0.018) were independent predictors of severe LA LVZ (LA LVZ >20%). The extent of LVZ was significantly greater in females than in males (32.8% ± 15.5% vs. 23.5% ± 12.7%, p = 0.021), especially in the anterior (34.5% ± 16.7% vs. 20.0% ± 16.4%, p = 0.003) and septal (44.9% ± 17.1% vs. 29.0% ± 18.9%, p = 0.004) walls. During follow-up, AF recurrence was significantly higher in patients with LA LVZ than in those without LA LVZ (31.3% vs. 12.8%, respectively, p = 0.023). Conclusions: In this study cohort, persistent AF, LAV and BNP were independent predictors of LA LVZ. Furthermore, female sex, LAV and BNP were independent predictors of severe LA LVZ. Females had a significantly greater extent of LVZ than males, especially in the anterior and septal walls. Patients with LA LVZ had a higher risk of recurrent AF.
Compte rendu: Neige Sinno, Triste tigre, Paris, P.O.L, 2023
Authors:   Universitatea din Bucureşti, Baba Alicia
Published: November 2023

Book review
Critique littéraire: Makenzy Orcel, Une somme humaine, Paris, Rivages, 2022
Authors:   Universitatea din Bucureşti, Florescu Fabiana
Published: November 2023

Literary critique
Ce qui se cache derrière un nom de famille: les biais de genre en français
Authors:   Université Paris Cité, Ionescu Ruxandra
Published: November 2023

This article presents a sentence completion task in French, which allows us to measure speakers’ preferences regarding the interpretation of surnames. The results show the weight of a sociolinguistic factor, namely gender bias, which causes speakers to unconsciously transgress the biases imposed by the two semantic types of verb (subject bias and object bias). The participants use all the mechanisms at their disposal to associate a surname with a male rather than a female individual. This shows the existence of a real bias for the masculine in the use of different structures in a language, and more generally, the link that exists between language and social prejudice. As our study replicates the same results for French as those observed for English, we can put forward the hypothesis that this bias is not specific to one language, but rather a general trend that manifests itself across languages. This study should be continued in other languages to validate our hypothesis.
L’alternance entre le sujet nul et pronominal en roumain dans une perspective romane
Authors:   Université Paris Cité, Istrate Fabian
Published: November 2023

This article focuses on the differences in the comprehension and the production of null and pronominal subjects in Romanian. It shows the importance of an empirical approach (experiments and corpus investigation) for the study of syntactic alternations, such us the null pronominal subject alternation in prodrop Romance languages, which cannot be described by the classical categorical syntactic constraints (cf. grammatical vs. agrammatical dychotomy), but rather by soft constraints, that reflect the preferences of the speakers for one structure or the other. This research allows us to observe (micro)variations within prodrop Romance languages. It also shows that an adequate analysis of such an alternation should be based on a multifactorial analysis, that takes into account factors from various linguistic levels (in particular syntax and discourse).
TERMINOLOGUE (DCU Dublin) – un outil de gestion terminologique pas comme les autres
Authors:   Universitatea din Bucureşti, Cheroiu-Cozma Ioana , Dinu Oana ,   Universitatea din Bucureşti, Vasile Mirela ,   Universitatea din Bucureşti
Published: November 2023

The purpose of this contribution is to present the main challenges of a localization project currently being finalized – the localization, into French and Romanian, of the open-source terminology management tool TERMINOLOGUE. The main point is to assert and assess a specific algorithm for the research of interlingual equivalents of terminological units lato sensu (terms, collocations, idioms, standardized text).
Jury Instructions Should Prioritize Reflector Variables Recorded During the First Test of an Eyewitness’s Memory
Authors: Huang Jiaqi , Wixted John
Published: November 2023

Jurors tend to be insensitive to the difference between reliable vs. unreliable eyewitness evidence, and jury instructions have been proposed as one way to address that problem. However, numerous studies have found that existing jury instructions are largely ineffective. Here, we test the effectiveness of instructions designed to capitalize on a new understanding of the importance of “reflector variables,” namely, confidence and decision time on the initial test of a witness’s memory. In three experiments, we found that reflector variable instructions successfully sensitized participants to strong eyewitness evidence (immediate-high confidence ID at the first test followed by a high-confidence ID at trial) vs. weak eyewitness evidence (hesitant-low confidence ID at the first test followed by a high-confidence ID at trial). Overall, our results provide evidence that reflector variable instructions can shift jurors’ attention from the more attractive in-court identification to the more important initial identification.
Sistem Otomasi Sitem Otomatis
Authors: Helmi Guswita
Published: November 2023

Penyakit Parkinson merupakan salah satu penyakit neurodegeneratif. Penyakit ini muncul karena beberapa faktor resiko yang berkontribusi seperti usia, jenis kelamin, dan beberapa faktor lain. Oleh sebab itu, identifkasi penyakit Parkinson sejak dini diperlukan untuk mencegah terjadinya resiko yang lebih buruk. Dalam membangun sistem identifikasi penyakit Parkinson secara otomatis membutuhkan dataset rekam medis. Dataset tersebut merupakan sekumpulan data frekuensi dan amplitudo gelombang suara dari beberapa subjek. Analisis data yang kuat merupakan hal yang paling menantang dalam mendeteksi penyakit Parkinson. Selain itu, juga diperlukan sebuah sistem yang cepat atau otomatis dalam menganalisis data klinis tersebut. Maka dari itu, kami mengusulkan sebuah sistem otomatis yang bertujuan untuk mendeteksi penyakit Parkinson menggunakan metode Fuzzy K-NN (K-Nearest Neighbor). Fuzzy K-NN merupakan modifikasi dari algoritma K-NN dengan menambahkan teknik fuzzy logic di dalamnya. Teknik ini mampu meningkatkan kinerja sistem dalam menentukan seseorang terdiagonsis penyakit Parkinson atau tidak. Metode yang kami usulkan menghasilkan nilai akurasi sebesar 90% di mana lebih baik 8%, 10%, 14.5%, dan 20% daripada metode Naïve Bayes, SVM, K-NN, Decision Tree.
Buku Ajar: Defenisi, Fungsi, Karakteristik dan Penilaian Buku Ajar
Authors: Azhar Muhammad
Published: November 2023

Artikel ini membahas definisi dan peran buku pelajaran dalam pembelajaran, pentingnya buku pelajaran dan fungsinya bagi guru dan siswa. Buku pelajaran dianggap sebagai landasan utama dalam proses pendidikan, memberikan waktu mengajar dan belajar, mengubah peran guru menjadi fasilitator, meningkatkan proses pengajaran dan pembelajaran, menjadi panduan, dan berperan sebagai alat penilaian.Selanjutnya, artikel menguraikan spesifikasi buku teks yang baik dan materi pembelajaran yang baik berdasarkan standar yang dikeluarkan oleh berbagai ahli. Standar tersebut mencakup keaslian, keterkaitan, fungsi, kinerja komunikatif, dan prinsip penilaian. Selain itu, penilaian terhadap kualitas buku teks melibatkan aspek materi, bahasa, penyajian materi, dan ilustrasi.Artikel ini juga mencakup tanggung jawab buku teks sebagai panduan bagi siswa, memberikan fleksibilitas dalam pembelajaran mandiri, dan menjadi alat penilaian hasil pembelajaran. Terakhir, artikel menguraikan aspek-aspek yang perlu dievaluasi dalam menilai kelayakan isi buku teks, seperti kebenaran materi, penggunaan bahasa, penyajian materi, dan ilustrasi.
sensor kelembaban
Authors: Wati Mutia Nurdina
Published: November 2023

Kelembaban tanah dan suhu merupakan parameter yang dibutuhkan tanaman dalam raangka pertumbuhan tanaman. Dalam menentukan kelembaban tanah dan suhu yang sesuai dengan tanaman membutuhkan suatu sistem pengendali. Sistem pengendali ini menggunakan Raspberry Pi sebagai pemroses data input menjaadi output. Pada sistem pengendali ini dirancang menggunakan logika fuzzy sebagai metode pengambil keputusan untuk mempertahankan kelembaban tanah dan suhu yang baik untuk tanaman. Logika fuzzy merupakan salah satu sistem pendukung keputusan yang cocok untuk diterapkan pada sistem pengendali. Logika fuzzy terdiri dari fuzzyfikasi, pembentukan aturan fuzzy dan defuzifikasi. Pada logika fuzzy ini menggunakan dua input dan dua output. Dua input tersebut adalah tingkat kelembaban tanah dan derajat suhu. Output yang diinginkan merupakan waktu yang dibutuhkan dalam mempertahankan kelembaban tanah dan suhu agar tetap sesuai dengan kebutuhan pada tanaman.
Does working memory modulate cross-linguistic structural priming?
Authors: Chen Xuemei
Published: November 2023

Many studies argued shared syntactic representations between languages. However, less is known whether cross-linguistic syntactic processing rely on cognitive resources (e.g., working memory). We therefore conducted two structural priming experiments with a working memory task (i.e., a number series recall task between prime and target) for Mandarin-Cantonese-English multilinguals. When prime and target involved different actions (Experiment 1), cross-language priming was similar not only between different languages (Cantonese-to-Mandarin vs. English-to-Mandarin), but also between different working memory load conditions (high vs. low). When prime and target shared the same action (Experiment 2), cross-language priming was stronger in Cantonese-to-Mandarin condition and in low load condition. Importantly, such a translation-equivalent boost effect occurred in low load condition but not in high load condition. These findings suggest an automatic processing of abstract cross-linguistic structural priming and an important role of working memory on translation-equivalent boost effect, supporting learning-based models of shared syntax among multilinguals’ languages.
Parenting and Adolescent Anxiety Within Families - A Biweekly Longitudinal Study
Authors: Šutić Lucija , Yıldız Ezgi , Yavuz Sala F. Cemre , Düzen Aylin , Keijsers Loes , Boele Savannah
Published: November 2023

This preregistered study examined the associations between parenting practices and generalized anxiety in adolescence. We used mesolongitudinal data from Dutch adolescents (N = 256, Mage = 14.39, 71.5% female) and one of their parents (N = 176, Mage = 46.77, 82% female). DSEM confirmed that families with more intrusiveness and less autonomy support had on average higher levels of anxiety symptoms. Within families, increases in intrusiveness and autonomy support were correlated to increases in adolescents’ anxiety symptoms. Regarding the bidirectional lagged effects, biweekly increases in adolescents’ anxiety predicted, on average, more intrusiveness and less autonomy support two weeks later. Although further studies are needed, these findings highlight the potential negative effects of adolescents’ mental health problems on the parent-adolescent relationship.
The impact of COVID-19 on the oral health self-care practices of Australian adults
Authors: McCormick Kym Michelle , Santiago Pedro Henrique Ribeiro
Published: November 2023

Aim: Grounded in Andersen’s Behavioral Mode (ABM), this study aims to explore the network of causal relationships between those factors influencing oral hygiene self-management (OHSM) behavior during the COVID-19 pandemic in Australia. Subject and Methods: Data was obtained from the Australian population. Participants (N = 563) aged between 19 and 91 years (M = 54.50, SD = 16.16) provided online responses between June, 2021, and May, 2022. The majority of participants were female (60.9%), employed either full-time (37.65%) or part-time (22.02%), and had completed an undergraduate degree or higher (70.1%). We implemented a triangulated approach, utilizing multiple modeling methodologies including Gaussian graphical model (GGM), directed acyclic graph (DAG), and structural equation modeling (SEM). These methodologies were employed in three predetermined stages, using a single cross-sectional dataset.Results: A causal model elucidating the influence of the COVID-19 pandemic on oral health self-management behavior was uncovered. The resulting GGM displayed an acceptable fit to the observed data. The DAG structure conformed to that expected by ABM, with all directed edges being also present as edges in the GGM. The subsequent SEM model specified by the DAG provided excellent fit to the data.Conclusion: Our study offers empirical evidence that factors such as appointment availability, dental care affordability, and the opportunity to engage in oral health discussions with individuals other than dentists during the pandemic directly contributed to inadequate oral health self-care.
Appraisal of labor management approaches within the private residential construction firms in the Kathmandu Valley
Authors: Sapkota Sachin , Subedi Manoj , Ale Dilip
Published: November 2023

Purpose - The purpose of this study was to investigate labor management practices in private housing developers in the Kathmandu Valley. Evaluating perception on current practices, identifying challenges, and proposing solutions to improve labor management were also part of the paper.

Design/methodology/approach - The research paper employed a quantitative approach and cross-sectional survey design to investigate the research objective. The researchers used the quota sampling method to select participants from employees and executives working on 17 under-construction projects, allowing for the sample size to be divided and participants to be selected based on specific characteristics. Data were collected from 85 respondents through self-administered questionnaires.

Findings - The findings indicate a preference for hiring trained and experienced workers but highlight inadequate communication channels and planning. The study also identifies challenges associated with inadequate wages, occupational health and safety, labor policy, unfair hearing, and insufficient training. The study recommends focusing on employee staffing, performance evaluation, work environment, training, and compensation management as remedial measures to address these challenges.

Conclusion - The paper advocates the critical need for improved labor management practices in the private housing sector. The paper highlights several challenges, including low wages, limited communication channels, weak control systems, and inadequate health and safety measures. To address these issues, it is essential to implement appropriate measures such as providing fair wages, offering economic benefits, establishing comprehensive occupational safety and health policies, prioritizing training and development programs, enhancing employee staffing procedures, and implementing effective performance evaluation frameworks.

Originality - This research brings originality to the field by examining labor management practices specifically within the private housing sector, a topic that has received limited attention in the context of Nepal.
Estimation of biomass obtained from different pruning carried out in a Eucalyptus plantation associated with native species in an experimental plot for forest landscape restoration
Authors: Mendoza Rober Alejandra Micaela , Quevedo Fernandez Maria Laura , Gamarra Ruíz Díaz Lila Mabel , Pérez de Molas Lidia Florencia , Silva Imas Haroldo Nicolas
Published: November 2023

The importance of conducting studies on biomass and carbon in forest plantations is undeniable. Hence, the objective of this study is to estimate and compare the dry biomass obtained from four pruning conducted in a Eucalyptus plantation associated with native species in an experimental plot for forest landscape restoration. The study area is situated in the district of Hernandarias, Alto Paraná department, Paraguay. The plantation is structured into five repetitions, where each experimental unit consists of production rows and conservation rows. The production row of each experimental unit comprises 32 trees of Eucalyptus urophylla S.T. Blake × Eucalyptus grandis W. Hill (clonei 144). To collect data, four pruning were carried out at 15, 18, 21, and 24 months. The two initial pruning were done using pruning shears, and the subsequent ones using saws with extendable handles. The first pruning was executed up to 1.50 meters (m), the second up to 2.60 m, the third up to 4 m, and the fourth up to 5 m in height, aiming to obtain knot-free wood. For sample processing, leaves were separated from branches and weighed immediately after pruning. Subsequently, a sample of approximately 200 grams was taken and placed in an oven at 60°C for roughly 72 hours until a stable weight was achieved. The total biomass was then estimated. The results show that at 15 months an average of 1.15 kilograms per hectare (kg/ha) of dry biomass was obtained; at 18 months, 1.60 kg/ha; at 21 months, 2.61 kg/ha, and at 24 months, 2.49 kg/ha of dry biomass. Estimating dry biomass through pruning provides valuable information to approximate the carbon stored in the branches and leaves of young eucalyptus plantations in Paraguay.
Use of Corneal Topography in Pediatric Ophthalmology
Authors: Popová Veronika , Tomčíková Dana , Bušányová Beáta , Kecer Filip , Gerinec Anton , Popov Ivajlo
Published: November 2023

Aim: To introduce the topic of pediatric keratoconus, highlighting the importance of routine corneal topography and tomography in children and adolescents from predisposed groups. To attempt to ensure the early detection of keratoconus and its subclinical form, enabling early treatment, which brings better expected postoperative results.
Material and methods: Using the corneal tomograph Pentacam AXL we examined children and adolescents with astigmatism equal or greater than
2 diopters (in at least one eye) and patients with at least one risk factor such as eye rubbing in the case of allergic pathologies, positive family history of keratoconus or certain forms of retinal dystrophy. In total, we included 231 eyes (116 patients), of which 54 were girls and 62 were boys.
Results: The Belin-Ambrósio deviation index parameter was evaluated, in which we classified a total of 41 eyes as subclinical keratoconus and 12 eyes as clinical keratoconus. Next, the corneal maps were evaluated individually, in which we included a total of 15 eyes as subclinical keratoconus and 6 eyes as clinical keratoconus. In our group, compared to the control group, subclinical and clinical keratoconus occurred most often in the group of patients with astigmatism and in the group of so-called “eye rubbers”. After individual evaluation, keratoconus occurred more frequently in boys than in girls in our cohort.
Conclusion: Most patients with keratoconus are diagnosed when there is a deterioration of visual acuity and changes on the anterior surface of
the cornea. Corneal topography and tomography allows us to monitor the initial changes on the posterior surface of the cornea, and helps us to detect the subclinical form of keratoconus and the possibility of its early treatment. Therefore, it is important to determine which groups are at risk and groups in which corneal topography and tomography should be performed routinely.
Torpedo Maculopathy. A Case Report
Authors: Šulavíková Zuzana , Krásnik Vladimír
Published: November 2023

Aim: Torpedo maculopathy is an incidental, congenital retinal lesion. The typical clinical finding is a unilateral, symmetric, oval, hypopigmented lesion in the inferotemporal macula. In most cases, the lesion is along the horizontal raphe, is torpedo-shaped, and the nasal edge is directed into the foveola. The diagnosis is determined on the basis of its characteristic shape, localization and findings on optical coherence tomography (OCT). The etiology and pathogenesis of torpedo maculopathy is unclear, but it is believed to be a congenital defect of the retinal pigment epithelium (RPE). The aim of this publication is highlight this diagnosis and to present an incidental finding of torpedo maculopathy in an adult patient.
Case report: A 30-year-old female patient reported for a routine eye examination. Fundus examination of the right eye revealed an oval hypopigmented lesion with a size of 1 disk diameter inferotemporally from the fovea, which was followed by a satellite lesion in the same axis directed into the foveola. Based on OCT, OCT angiography, fundus autofluorescence, and the typical shape and location of the lesion, the patient was diagnosed with torpedo maculopathy in the right eye.
Conclusion: In general, torpedo maculopathy is an asymptomatic, congenital, benign retinal lesion, which is mostly diagnosed accidentally during a routine fundus examination. TM is non-progressive retinal finding with a minimal risk of deterioration of visual functions, which does not require any treatment. Nevertheless, due to the rare risk of a choroidal neovascular membrane, it is recommended to examine patients once a year. It is necessary to consider this diagnosis when a unilateral hypopigmented lesion is found inferotemporally from the fovea, and to distinguish it from chorioretinal atrophy, scar, vitelliform dystrophy, or other RPE lesions as part of the differential diagnosis.
ЦІННІСНІ АСПЕКТИ ОРГАНІЗАЦІЇ СИСТЕМИ ШКІЛЬНОЇ ОСВІТИ ІЗРАЇЛЮ: ДОСВІД ДЛЯ УКРАЇНИ
Authors: Шапран Ольга
Published: November 2023

У статті розглянуто сучасну систему шкільної освіти в Ізраїлі, що поділена на цикли (початковий, середній, старший) і спрямована на підготовку молоді до відповідального життя в демократичному суспільстві, де разом проживають люди з різним етнічним походженням, релігією, культурою, політичними поглядами, моральними устоями. Визначено особливості організації освітнього процесу у таких типах ізраїльських шкіл як державні, з релігійним ухилом, державно-релігійні, приватні. Доведено, що шкільна освіта Ізраїлю заснована на єврейських цінностях, на любові до своєї землі, рівності, соціальній гармонії, гуманізмі, універсалізмі, на принципах свободи і терпимості, толерантності. Вивчення досвіду навчання молоді на єврейських цінностях в Ізраїлі дозволило визначити шляхи покращення освіти у закладах загальної середньої освіти України в період воєнних дій у державі (розширення демократичності як цінності і можливості для учнів обирати навчальні дисципліни та формувати індивідуальну траєкторію особистісного розвитку школярів; орієнтація освітнього процесу ЗЗСО на особистісно орієнтований підхід до учнів, зменшення кількості годин в українських школах на різних циклах навчання від початкової та базової освіти до профільної середньої освіти, більш ґрунтовне визначення спеціалізації школярів в ліцеях і старшій школі не лише за отриманими оцінками з окремих навчальних дисциплін, але й результатами спеціальних психологічних тестів, що визначають їх нахили; доповнення формальної освіти дітей в українських школах неформальною освітою, приділення значної уваги розвитку стресостійкості та запобіганню депресивних станів у молоді, ораторському мистецтву і комунікативній культурі з використанням інтерактивних технологій та інноваційних форм навчання (тренінги, індивідуальні консультації, психологічна допомога); розвиток патріотизму учнів шляхом залучення їх до громадських молодіжних організацій, покращення довійськової підготовки в школі. Доведено, що акт прийняття рішення учнем у конкретній ситуації тісно пов’язаний з громадянськими і особистісними цінностями суб’єктів освітньої діяльності.
Literature Review: Physical Activity, Diet, and Socioeconomics on Obesity in Elementary Schools
Authors: Aji Tegar Pandu Laras , Sulistiono  , Harmono Setyo
Published: November 2023

The global obesity rate has doubled since 1980, leading to widespread health concerns. This study analyzes the relationships between physical activity, dietary patterns, and socioeconomic status on obesity in elementary school children. Based on a review of 11 national and international articles published between 2016 and 2020, the study finds that factors contributing to childhood obesity include sedentary behavior, poor dietary habits, genetic predisposition, and environmental influences. Results suggest a strong correlation between reduced physical activity and increased obesity risk, along with a connection between unhealthy dietary patterns and the prevalence of obesity. Additionally, the study highlights the influence of socioeconomic factors on dietary choices, particularly in the context of the availability and affordability of fast food. These findings emphasize the need for comprehensive interventions and awareness campaigns to promote healthy lifestyles and prevent childhood obesity.
Жирнокислотний спектр мембран лімфоцитів у хворих на ішемічну хворобу серця
Authors: Zavalska T. V.
Published: November 2023

Досліджено жирнокислотний спектр фосфоліпідів мембран лімфоцитів у 77 хворих на ішемічну хворобу серця віком 45–72 років. Встановлено достовірне зменшення відносного вмісту олеїнової жирної кислоти, що порушує будову мембран лімфоцитів та, можливо, негативно впливає на їх функціонування. Виявлено підвищення відносного вмісту арахідонової поліненасиченої жирної кислоти, пальмітинової та стеаринової насичених жирних кислот у складі загальних ліпідів лімфоцитів крові. Результати цих досліджень вказують на те, що при даній патології в лімфоцитах відбувається посилення елонгації поліненасичених жирних кислот. Вказані зміни показників стану ліпідного комплексу лімфоцитів крові дозволяють пояснити виявлене підвищення їхньої функціональної активності.
Лікування та профілактика поєднаної кардіореспіраторної патології при загостренні хронічного обструктивного захворювання легень (новий підхід)
Authors: Gerych P. R. , Yatsyshyn R. I.
Published: November 2023

Вивчали особливості перебігу загострення хронічного обструктивного захворювання легень (ХОЗЛ) у поєднанні з ішемічною хворобою серця (ІХС) як у формі стабільної стенокардії напруги (ССН), так і при загрозі дестабілізації її перебігу. Проаналізовано зміни серцево-судинної системи на фоні клінічної симптоматики у хворих із загостренням ХОЗЛ ІІ–ІІІ стадії. Розроблено диференційовані підходи до протизапальної і кардіопротекторної дії комбінації препаратів рофлуміласту і кверцетину як складових комплексної терапії у хворих при поєднаній кардіореспіраторній патології.
Досвід діагностики та лікування хвороби Делафуа
Authors: Pyatikop G. I. , Kravets O. V. , Moskalenko R. A. , Bratushka V. O.
Published: November 2023

Стаття присвячена особливостям діагностики та лікування хвороби Делафуа. Наведено клінічну характеристику шістьох випадків даної патології. Описано морфологічні особливості виразки Делафуа. Проаналізовано один летальний випадок захворювання.
Застосування препарату Проноран® в осіб похилого віку при синдромі помірних когнітивних порушень
Authors: Bachinska N. Yu. , Rozheliuk I. F.
Published: November 2023

Оцінювали ефективність застосування препарату Проноран® при синдромі помірних когнітивних порушень (ПКП) на фоні дисциркуляторної енцефалопатії в осіб похилого віку. Обстежено 48 осіб: І (основна) група – 27 хворих, які на фоні базисної терапії отримували препарат Проноран®; ІІ (контрольна) – 21 хворий, якому проводили базисну терапію. Встановлено, що під впливом 3-місячного курсу лікування у пацієнтів основної групи спостерігалося достовірне покращання показників, що характеризують орієнтування в просторі, короткотривале запам’ятовування, рахунок, концентрацію уваги, психомоторний темп, здатність до навчання. Також курсовий прийом препарату супроводжувався поліпшенням емоційного стану, позитивними змінами коефіцієнтів спектральної потужності комп’ютерної електроенцефалографії. Разом з тим в осіб ІІ групи достовірних змін досліджених параметрів не встановлено.
Nuevo registro de Molossus melini (Chiroptera, Molossidae) para Santa Fe, República Argentina
Authors: Montani M. Eugenia , Barberis Ignacio M. , Diaz M. Monica
Published: November 2023

Se registra la segunda localidad para Molossus melini en la provincia de Santa Fe y la tercera para Argentina. El registro corresponde a un ambiente rural en la ecorregión Pampa. Esta nueva localidad amplía el rango de distribución conocido de la especie hacia el oeste entre la localidad tipo en la provincia de Santa Fe y el registro de la provincia de Entre Ríos. Además, se aportan datos de morfometría externa e información reproductiva de la especie.
Povijest naziva cjepivo u hrvatskoj leksikografiji
Authors: Lewis Kristian , Vrgoč Dalibor
Published: November 2023

U ovome je radu istraživački interes usmjeren na prve zapise, tvorbu i razvoj značenja naziva cjepivo u hrvatskome jeziku u medicinskome, konkretnije imunološkome smislu – od njegovih prvopotvrđenica u leksikografskim vrelima i periodici druge polovine 19. stoljeća preko najstarijih terminoloških rječnika do njegova bilježenja u kasnijim rječničkim i enciklopedijskim ostvarenjima. Pokazat će se kako je hrvatski jezik nedugo nakon revolucionarne pojave koncepta cijepljenja (vakcinacije) zaslugama oca vakcinologije Edwarda Jennera, a time posljedično i cjepiva, pronašao tvorenicu koja nije ustupila mjesto internacionalizmu vakcina. Štoviše, jedan je od rijetkih slavenskih jezika koji se nije priklonio posuđenici. Ovim se istraživanjem još jednom potvrđuje teza o bogatim tvorbenim mogućnostima hrvatskoga jezika, koje su posebno zaživjele u jeku njegova terminološkoga procvata u drugoj polovini 19. stoljeća. U istraživanju se iznosi i pregled nastanka naziva cjepivo u engleskome, jeziku u kojemu je i osmišljen taj naziv i razvijena njegova tvorbena porodica, te se iznose novi pogledi na dosadašnje zaključke o vrsti riječi koju je jenner namijenio obliku vaccine.
ANALISA FAKTOR YANG MEMPENGARUHI MASYARAKAT DI WILAYAH BERKEMBANG DALAM BERPARTISIPASI DALAM PENGOLAHAN SAMPAH BERBASIS BLACK SOLDIER FLY (STUDI KASUS: KECAMATAN PANTAI LABU, SUMATERA UTARA)
Authors: Karim Ahmad Yusri , Rahman Ari , Suryawan I Wayan Koko
Published: November 2023

Kecamatan Pantai Labu, Sumatera Utara tidak lepas dari permasalahan pengelolaan sampah yang dapat berdampak pada kesehatan manusia dan ekosistem. Metode yang lebih berkelanjutan untuk menyelesaikan masalah penumpukan sampah secara efisien. Sejumlah penelitian telah menggaris bawahi penggunaan larva lalat tentara hitam  (BSF) sebagai kandidat terbaik untuk pengolahan sampah organik . Tulisan ini bertujuan untuk menjawab pertanyaan, faktor-faktor apa saja yang mempengaruhi niat masyarakat di daerah berkembang dalam kemauan mengolah sampah. Analisis faktor eksplorasi (EFA) digunakan dalam studi ini untuk mengidentifikasi jumlah terkecil dari beberapa konstruksi hipotetis dengan software SPSS. Atribut pertanyaan yang digunakan dalam studi ini terdiri dari 10 butir pertanyaan yang telah diuji realabilitas dan validitasnya. Dalam studi ini memperlihatkan 3 varians dalam analisa ini. Kaiser-Meyer-Olkin (KMO) dan Uji Bartlett dari Sphericity memperlihatkan hasil yang memuaskan untuk model faktor yang dihasilkan dalam studi. Tiga faktor yang terbentuk tersebut terdiri dari perencanaan pengelolaan sampah, pandangan urgansi masyarakat, dan pengetahuan pengolahan sampah saat ini. Perencanaan peningkatan kesadaran dan kepedulian pengelolaan sampah dari akan menyebabkan pengembangan pengelolaan sampah sebagai fungsi penting dari manajemen proyek pengembangan BSF.  Sistem Pengelolaan Sampah Berbasis Masyarakat (SPSBM) sebagai pendekatan alternatif untuk teknik pengelolaan sampah yang umum ditemukan di daerah berkembang seperti Kecamatan Pantai Labu.
Kinesthetic and Visual Feedback in Online Vocal Lessons
Authors: Zakrasniana Zhanna
Published: November 2023

The purpose of the research is to analyze the possibilities and impact of kinesthetic and visual feedback on the quality of online vocal lessons. Research methodology. The article uses the following methods: experimental, retrospective and observation. The scientific novelty of the study of kinesthetic and visual feedback in online vocal lessons is to examine the effectiveness of these two methods of providing feedback in the online environment. Such a study can help to establish scientifically based approaches to the use of kinesthetic and visual feedback in online classes and provide a basis for further development and improvement of the methodology of vocal pedagogy. Conclusions. Kinesthetic and visual feedback allows students to feel their bodies and voices, which helps to identify problematic moments and shortcomings in technique. With these sensations in mind, students can work on correcting incorrect movements, controlling their breathing, and improving their technique. In addition, kinesthetic and visual feedback can serve as a source of motivation and encourage students to exercise self-discipline. Through conscious performance and seeing their progress on video, students can feel motivated to continuously improve their technique and achieve their goals in vocal performance. Thus, kinesthetic and visual feedback contributes to effective online vocal training, the development of technique, consciousness and communication between student and teacher, as well as encourages motivation and self-discipline.
Подорожні нариси про Італію в західноукраїнських часописах першої третини ХХ століття: українські алюзії
Authors: Ґабор Василь
Published: November 2023

Проаналізовано понад двадцять подорожніх нарисів про Італію, у яких наявні українські алюзії. Досліджено, що серед яскравих опосередкованих та прямих українських алюзій і порівнянь можна виділити такі умовні групи: 1) короткі екскурси в українську історію та окремі історичні вкраплення; 2) використання українських реалій у порівняннях, згадки про українських письменників і цитування їхніх творів, співзучних настроям авторів; 3) рефлексії щодо впливів італійської культури й мистецтва на українську; 4) сприйняття італійцями України та «українізація» західноукраїнськими авторами імен італійських митців.

З’ясовано, що провідні західноукраїнські часописи першої третини ХХ ст., такі як «Літературно-Науковий Вістник», «Діло», «Новий Час», «Час» та «Назустріч», систематично публікували подорожні нариси, у яких наявні українські алюзії. Однак редакційна політика видань щодо публікації подорожніх нарисів була різною. У більшості з цих часописів друкувалися подорожні нариси різних за фахом авторів, що сприяло багатовекторності поглядів та емоційного сприйняття історичного, мистецького й духовного світу Італії, однак в «Літературно-Науковому Вістнику» та «Новому Часі» містилися подорожні есеї виключно їхніх редакторів, що суттєво звужувало широту поглядів та різноманітність емоційного тла.

У подорожніх нарисах відомих учених, митців та журналістів – Михайла Грушевського, Гавриїла Костельника, Осипа Назарука, Михайла Посацького, Святослава Гординського, Григорія Смольського, Михайла Островерхи, Миколи Троцького та ін. – виразно простежуються українські алюзії, які сприяли спорідненню нашого народу та його історії з іншими народами, їхньою культурою й дозволяли українцям відчувати себе частиною європейської цивілізації.
REPURCHASE INTENTION PADA BITCOIN DI INDONESIA
Authors: Nainggolan Ferdinand , Lady Lady , Harianja Ervinasari
Published: November 2023

Investasi pada Bitcoin di Indonesia meningkat setiap tahunnya, hal ini dikarekan para investor yang melihat peluang keuntungan yang baik dan mengerti pentingnya untuk melakukan investasi. Hal ini juga didasari, bahwa bitcoin sebagai wadah investasi yang dianggap mudah untuk digunakan menjadi pilihan para investor. Penelitian ini dilakukan guna mengetahui faktor apakah yang menjadi pendorong dalam melakukan repurchase intention terhadap bitcoin. Metodologi penelitian ini adalah dengan penyebaran kuesioner melalui form online terhadap 172 investor bitcoin yang melakukan pembelian bitcoin secara berkelajutan. Pada penelitian ini menemukan bahwa perceived of enjoyment, expectation dan perceived ease of use dalam penggunaan berpengaruh signifikan terhadap repurchase intention bitcoin, sedangkan satisfaction dalam penggunaan tidak memiliki pengaruh terhadap repurchase intention bitcoin.
Multi-objective hyperparameter optimization approach with genetic algorithms towards efficient and environmentally friendly machine learning
Authors: Yokoyama André M. , Ferro Mariza , Schulze Bruno
Published: November 2023

This paper presents a multi-objective optimization approach for developing efficient and environmentally friendly Machine Learning models. The proposed approach uses Genetic Algorithms to simultaneously optimize the accuracy, time-to-solution, and energy consumption simultaneously. This solution proposed to be part of an Automated Machine Learning pipeline and focuses on architecture and hyperparameter search. A customized Genetic Algorithm scheme and operators were developed, and its feasibility was evaluated using the XGBoost ML algorithm for classification and regression tasks. The results demonstrate the effectiveness of the Genetic Algorithm for multi-objective optimization, indicating that it is possible to reduce energy consumption while minimizing predictive performance losses.
The 2023 New York SDG Summit Outcome: Rescue Plan for 2030 Agenda as a Wake-up Call for the Decision-makers
Authors: Desai Bharat H.
Published: November 2023

As a plenary organ of the UN, the General Assembly has invoked its principal instrumentality of resolutions to address a variety of global problems. The mirage of being called “recommendations” (Article 11, the UN Charter) has never come in the way of finesse with which the Assembly has invoked its resolutions to zero in on contemporary common concerns. The 2030 Sustainable Development Goals (SDGs) adopted by resolution 70/1 (September 25, 2015) has been one such major global action plan that became a milestone in a long line of engagements that have also carried the normative halo. Now at the mid-way to the 15-year cycle (2015–2030), the performance assessment on 17 Goals shows that the promise of leaving “no one behind” is in peril. In view of the reality of the world we live in and multiple interconnected planetary scale crisis situations, the UN member states have floundered in giving effect to the promises laid down in the 17 Goals of the 2030 Agenda. The UN Secretary-General’s report (April 27, 2023) has called for a resolute rescue plan for people and planet. The progress came to be reviewed at the SDG Summit convened by the UNGA President during September 18-19, 2023. The available data ( Revised Zero Draft of June 8, 2023), underscored the gravity of the peril faced by the humankind since, out of 140 targets, “only about 12 per cent are on track; more than half, although showing some progress, are moderately or severely off track; and some 30 per cent have either seen no movement or regressed below the 2015 baseline”. The Political Declaration adopted at the New York SDG Summit coinciding with the meeting of the High-Level Political Forum, sought to work out a rescue plan considering the UNSG’s stimulus plan and taken the “pledge to act now, for present and future generations”. This article examines the process, the promise, the pledge and the rescue plan for the SDGs in peril.
Minding the gap: Bibliometric equity in theology and religious studies
Authors: Xu Shenmeng , Anderson Clifford B. , Lew Charlotte
Published: November 2023

The scholarly communications ecosystem in theology and religious studies differs significantly from other disciplines. In this paper, we draw on a multi-year investigation at Vanderbilt University as well as a practitioner’s perspective at the Center of Theological Inquiry to document the extent to which existing bibliometric tools fail to capture the full scholarly output of scholars in these subdisciplines. After presenting our findings, we express hope that open-source and crowdsourced bibliometric initiatives based on linked data principles may help to correct existing imbalances and lead toward a more equitable representation of scholarly works in the field of theology and religious studies.