bluuebunny/crossref_metadata_2025 huggingface dataset:
Características produtivas de Kinosternon scorpioides nas fases de acasalamento, postura e eclosão, criados em cativeiro na Amazônia
Authors: Costa J.S. , Matos A.S. , Marques L.C. , Silva C.S. , Figueiró M.R. , Sales R.L. , Da Silva Filho E. , Guimarães D.A.A. , Marques J.R.F.
Published: July 2017

Objetivou-se estudar os índices das características produtivas de muçuãs (Kinosternon scorpioides) visando nortear manejos adequados para a sustentabilidade da atividade. Analisou-se 84 acasalamentos, 742 posturas e 1979 nascimentos em cativeiro, determinando-se: a estação reprodutiva e a distribuição dos acasalamentos; a duração do acasalamento; a razão sexual; a duração do período de desenvolvimento do ovo (PDO); a frequência de múltiplas posturas; duração do período de nidificação; a correlação entre tempo de nidificação e número de ovos; o número de ovos viáveis; a correlação entre número, peso, comprimento e largura dos ovos; a análise descritiva para as características biométricas e peso dos ovos; a duração do período de incubação; a estação de nascimentos; as análises descritivas de peso e medidas corporais para os filhotes e a correlação entre as variáveis. A estação reprodutiva é sazonal, concentrando os acasalamentos na época mais chuvosa do ano com duração média de 00:23:00 h, com razão sexual de 2,38 ± 1,67:1. O PDO foi de 122,98 ± 45,38 dias. A distribuição das posturas apresentou uma tendência de clímax entre junho e agosto. A duração da nidificação foi de 02:57:00 h. A viabilidade dos ovos foi de 20%. A correlação entre as características biométricas, peso e o número de ovos foi positiva. Os resultados biométricos do ovo foram de 34,5 mm de comprimento e 18 mm de largura, com peso de 7,90 g. O período de incubação foi de 129,31 ± 19,57 dias, com os nascimentos se concentrando entre os meses de setembro a dezembro. As correlações das características biométricas com o peso dos filhotes foram positivas.
Estudo exploratório da precificação dos cortes ovinos comercializados em mercados on line em diferentes países
Authors: Maysonnave G.S. , Campara J.M. , Vaz F.N. , Pascoal L.L. , Mello R.O. , Vargas F.V. , Pacheco P.S.
Published: July 2017

O objetivo deste trabalho foi verificar o comportamento da precificação de cortes ovinos em diferentes mercados de comercialização on-line com o intuito de identificar fatores de agregação de valor para a cadeia produtiva da ovinocultura brasileira. Foram analisados 601 dados de diferentes países, nos meses de fevereiro, março e abril do ano de 2015 com base em uma pesquisa on-line. Os resultados mostram que a maior média de preço entre todos os países pesquisados é a dos Estados Unidos. Considerando somente o continente americano, Estados Unidos e Brasil apresentaram os primeiros lugares; no continente europeu a Escócia e na Oceania a Nova Zelândia foram os que apresentaram os primeiros lugares. Quanto ao porcionamento, os valores oscilaram de US$ 9,58/kg a US$ 28,25/kg, e os maiores valores foram observados para produtos em pedaços ou fatiados. Quanto à conservação, entre as observações com categorias informadas, resfriado, congelado e vácuo tiveram preços entre US$ 10,54/kg a US$ 15,78/kg. Nos miúdos comestíveis a maior média de preço foi para o pâncreas (US$ 31,08/kg). Entre as categorias carnes de cordeiro e carnes de ovelha, a primeira apresentou maior preço (US$ 20,53/kg) em relação à segunda (US$ 10,15/kg). Os preços mostraram alta variabilidade, provavelmente devido às variações culturais, de renda e hábitos gastronômicos de cada mercado.
Valores econômicos para as características de produção, funcionais e de fertilidade em sistemas de produção de leite no Sul do Brasil
Authors: Cervo H.J. , Barcellos J.O.J. , Peripolli V. , Colle G. , McManus C.
Published: July 2017

O objetivo deste estudo foi prever os valores econômicos para características de produção, funcionais e de fertilidade, bem como para classificá-las em ordem de importância econômica para os sistemas de produção de leite no sul do Brasil. Para isso, dois grupos foram formados, de acordo com a sua produção, e as características consideradas foram: a produção de leite (L), a persistência da lactação (PL), a gordura do leite (GOR), a proteína do leite (PROT), a contagem de células somáticas (CCS), a idade de primeiro parto (IPP), o intervalo entre partos (IP), o consumo de ração (Consumo), a mortalidade (MORT) e o peso da vaca (PV). A receita baseou-se na venda de leite, de novilhas excedentes e de vacas de descarte, e os custos reais de operação foram utilizados para calcular o lucro e a margem bruta. A função de lucro utilizada para calcular os valores econômicos foi baseada em uma fazenda de 100 vacas. Os valores econômicos médios das características que afetam o lucro do produtor foram em ordem: GOR: US $ 3.776,07; PROT: US $ 1.888,03; L US $ 1.258,69, PL: US $ 1.258,69; PV: US $ 124,03; MORT: US $ -14,30; Consumo: US $ -614,01; IP: US $ -1.023,62; IPP: US $ -2.724,29; CSS: US $ -3.146,87. Os valores econômicos calculados para o volume de leite, fertilidade, qualidade do leite, resistência a doenças e consumo de ração, indicou que o uso dessas características como objetivos de seleção em programas de melhoramento deve resultar em aumento da rentabilidade para o produtor.
Caracterización comercial y nutricional de la grasa subcutánea de terneros y vacas de desvieje sacrificados en la Comunidad Autónoma del País Vasco
Authors: Aurtenetxe M. , Belaunzaran X. , Bravo-Lamas L. , Gamarra D. , Barron L.J.R. , Aldai N.
Published: July 2017

Este trabajo se ha llevado a cabo con el objetivo de comparar la calidad comercial de la canal y la composición de ácidos grasos de la grasa subcutánea de vacas de desvieje de raza Frisona de más de 30 meses de edad, y de terneros de 12 meses de edad de las razas Pirenaica y Salers sacrificados en un matadero comercial de la Comunidad Autónoma del País Vasco. Las vacas de raza Frisona presentaron canales de menor peso (p<0,05), aunque similar al grupo de los terneros de raza Pirenaica y menor conformación (p<0,001) y estado de engrasamiento (p<0,01) en comparación con los grupos de terneros. La grasa subcutánea de las vacas de desvieje presentó un mayor contenido de ácidos grasos saturados (p<0,001) y ramificados (p<0,05), y un menor contenido de ácidos grasos monoinsaturados (p<0,01) y poliinsaturados (p<0,001) en comparación con la de los terneros de las razas Pirenaica y Salers. El porcentaje de ácidos grasos monoinsaturados de tipo trans fue significativamente superior en la grasa subcutánea de los terneros de raza Pirenaica (p<0,001), mientras que el contenido de 10t-18:1 fue significativamente mayor en la grasa de terneros de raza Pirenaica, intermedio en la grasa de terneros de raza Salers, y menor en la grasa de las vacas de desvieje (p<0,001). Esto dio lugar a una relación 10t/11t <1 y un perfil isomérico relativo de trans-18:1 y ácidos linoleico conjugados más saludable en la grasa de las vacas de desvieje de raza Frisona en comparación con los grupos de terneros. Esta idea podría contribuir a la valorización de las canales procedentes de vacas de desvieje desde el punto de vista de su comercialización y de la rentabilidad de las explotaciones ganaderas de vacuno en la Comunidad Autónoma del País Vasco.
Suplementação com óleo de coco para leitões até o desmame
Authors: Deminicis R.G.S. , Mendonça P.P. , Paula M.O. , Deminicis B.B. , Moreira Y.R.
Published: July 2017

Objetivou-se avaliar o desempenho e mortalidade de leitões do nascimento à desmama submetidos a dieta suplementada com óleo de coco, bem como realizar a caracterização ambiental das instalações. O experimento foi realizado utilizando instalações suinícolas de maternidade. O delineamento experimental foi em blocos inteiramente casualizados, com 2 tratamentos, oito blocos e doze leitões por unidade experimental. Os leitões que foram suplementados receberam 12 ml de óleo de coco. Os escamoteadores proporcionaram condições estáveis nas horas mais quentes do dia, em relação às baias. A umidade relativa do ar permaneceu abaixo dos patamares ideais para os suínos nos horários mais quentes do dia; o ITGU esteve apropriado na recomendação do conforto térmico. Foi verificado que não houve efeito (p>0,05) do uso de suplementação com óleo de coco sobre o ganho de peso médio diário (g/dia) dos leitões até o desmame, os valores alcançados foram 227 g/dia e 228 g/dia, sem o uso e com o uso de óleo de coco respetivamente. A taxa de mortalidade dos leitões suplementados foi de 1,66% e aqueles que não receberam a suplementação foi de 5%, mostrando a importância do óleo de coco quando se leva em consideração a produção de leitões por matriz.
Parâmetros genéticos para características de crescimento e reprodutivas em bovinos Nelore no Brasil
Authors: Barbosa A.C.B. , Carneiro P.L.S. , Rezende M.P.G. , Ramos I.O. , Martin-Filho R. , Malhado C.H.M.
Published: July 2017

Conhecer o progresso genético e fenotípico de uma população é importante para se avaliar o resultado dos programas de seleção adotados e como elementos norteadores de ações futuras. Assim, objetivou-se estimar parâmetros genéticos, tendências genéticas e fenotípicas dos pesos aos 205 (P205), 365 (P365) e 550 (P550) dias de idade, idade ao primeiro parto (IPP), circunferência escrotal (CE) e intervalos de partos (IDP) de 175.231 bovinos Nelore, nascidos no período de 1967 a 2011 na região Nordeste do Brasil. Os componentes de (co) variância e valores genéticos foram obtidos por meio da metodologia da máxima verossimilhança restrita. As estimativas dos coeficientes de herdabilidades para as características de crescimento foram de baixa a moderada magnitude. A seleção direta proporcionará maiores ganhos genéticos para P550. Para as características reprodutivas, a estimativa de herdabilidade foi baixa para IPP e próxima a zero para IDP. Contudo, para a CE a herdabilidade foi moderada, indicando seu uso como critério de seleção. As tendências genéticas diretas para P205, P365, P550 e IPP, indicam pequenos ganhos genéticos ao longo dos anos. Os progressos fenotípicos evidenciam que as características estão melhorando com o decorrer dos anos, principalmente em decorrência da melhoria ambiental.
Potenciales de las fuentes no convencionales de proteína en la alimentación de animales no rumiantes
Authors: Olarotimi O.J. , Adu O.A.
Published: July 2017

Este trabajo revisa las investigaciones sobre el uso de fuentes no convencionales de proteína de origen vegetal para la avicultura en Nigeria y otros paises vecinos. Como el coste de los piensos compuestos continua siendo una carga para los granjeros nigerianos debido al alto coste actual de las fuentes convencionales de proteína tales como harina de pescado, torta de cacahuete y harina de soja, es muy urgente explorar los potenciales de fuentes alternativas no convencinales de proteína, especialmente harinas de hojas de algunas plantas, tales como Moringa oleifera, Leuceana leucocephala, Manihot esculenta, Carica papaya y otros piensos leguminosos los cuales pueden, de alguna forma, sustituir la inclusión de fuentes convencionales de proteína. Esas fuentes alternativas no convencionales tienen un excelente valor nutritivo y propiedades terapéuticas. Sus contenidos de proteína bruta son excelentes. Resulta aparente por varios estudios previos que la inclusión de esas fuentes proteícas no convencionales en las dietas avícolas mejora el rendimiento de los pollos en término de tasa de crecimiento y producción de huevos. Sin embargo, sus niveles de inclusión recomendados deben de ser estrictamente ajustados para evitar cualquier efecto deletéreo que pueda tener sobre los pollos. Por ejemplo, la inclusión de la harina de hojas de Moringa oleifera (MOLM) hasta el 10% en dietas de gallinas ponedoras se ha comprobado que es segura. Por lo tanto, será una novedad su inclusión en alimentos avícolas sin producir efectos nocivos para el rendimiento de las aves así como para los consumidores de los productos y, finalmente, dando lugar a mejores beneficios de los granjeros.
Clinical Manifestation and Errors in the Diagnosis of Classical Paroxysmal Nocturnal Hemoglobinuria:
Authors: Kulagin A.D. , Klimova O.U. , Dobronravov A.V. , Ivanova M.O. , Rudakova T.A. , Babenko E.V. , Dobronravov V.A. , Afanas'ev B.V.
Published: July 2017

Background. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder, characterized by intravascular hemolysis, cytopenia and thrombosis. Diagnostic errors with delayed diagnosis of PNH are often due to the variety of the clinical presentation and the lack of awareness of the doctors of this rare disease. Aim. The aim of the study was to characterize the spectrum of clinical manifestations and the complexity of diagnosis of classical PNH. Materials & Methods. The study included 150 patients with classical PNH. The inclusion criteria were: 1) clinical and laboratory signs of intravascular hemolysis; 2) verification of the diagnosis using standard flow cytometry; 3) absence of aplastic anemia, myelodysplastic syndrome and primary myelofibrosis. Results. The study population consisted of 89 (59 %) women and 61 (41 %) men. Median age was 34 years (13-72 years). The time before the diagnosis ranged from 0 to 455 months (median 33 months). The median size of the PNH clone among granulocytes and erythrocytes was 95 % and 41 %, respectively. The median of the lactate dehydrogenase was 7.2 times the upper limit of normal (ULN). Cytopenia occurred in 65 % of patients, including a combination of thrombocytopenia and neutropenia in 29 % of cases. Weakness and fatigue (99 %), hemoglobinuria (57 %), pain (52 %), icterus (46 %), dysphagia (37 %) and infection/fever (23 %) were the most common symptoms on the onset of the disease. Before the diagnosis of PNH, thrombosis or acute kidney injury was found in 22 % and 12 % of patients, respectively. Only 22 % of patients were initially diagnosed with PNH. In the remaining patients, the primary diagnosis was incorrect. Conclusion. The clinical manifestation of PNH is characterised by the presence of hemoglobinuria, cytopenia and early thrombosis in 57 %, 65 % and 22 % of patients, respectively. Errors of the primary diagnosis reach 78 % and lead to inadequate treatment. The results of the study showed the need for multidisciplinary approach and strict adherence to diagnostic algorithms of PNH in the risk groups, according to current recommendations.
Acute Lymphoblastic Leukemia with t(4; 11)(q21; q23)/KMT2A-AFF1 Translocation: The Results of Allogeneic Hematopoietic Stem Cells Transplantation in Children and Adults
Authors: Gindina T.L. , Mamaev N.N. , Paina O.V. , Borovkova A.S. , Kozhokar' P.V. , Slesarchuk O.A. , Gudozhnikova Ya.V. , Darskaya E.I. , Alyanskii A.L. , Bondarenko S.N. , Zubarovskaya L.S. , Afanas'ev B.V.
Published: July 2017

Aim. The aim was to evaluate the results of the allogeneic hematopoietic stem cells transplantation (allo-HSCT) in children and adults with the most prognostically unfavorable acute lymphoblastic leukemia (ALL) with t(4; 11)(q21; q23)/KMT2A-AFF1 translocation. Methods. We examined 21 patients (12 females, 9 males) aged from 3 months to 48 years (median 18.9 years). The analysis of prognostic factors of overall (OS) and eventfree survival (EFS) after allo-HSCT in patients of different age groups with various clinical, transplantation and cytogenetic characteristics was performed. Allo-HSCT from HLA-compatible related and unrelated donors, as well as haploidentical allo-HSCT were performed in 4, 9 and 8 patients of age groups < 1 year, 1-18 years, and >18 years, respectively. In 10 (48 %) patients, allo-HSCT was performed in the first remission, in 2 (10 %) patients in the second remission, and in 9 (43 %) patients during the disease relapse. Results. In 8 (38 %) patients, the only chromosomal disorder was the translocation t(4; 11)(q21; q23). Additional changes in chromosomes were found in 11 (52 %) patients. In 8 (38 %) of them, 3 or more chromosomal abnormalities in the karyotype were found. According to the results of a univariant analysis, the OS and EFS were significantly different in patients with allo-HSCT performed in the first remission and at other stages of ALL (in the second remission and in relapse: p < 0.001 in both cases), as well as in patients with or without 3 or more cytogenetic disorders in the karyotype (p = 0.04 in both cases). The multivariant analysis showed that the only independent prognostic factor affecting the OS and EFS in ALL patients with t(4; 11) was the allo-HSCT, including the haploidentical procedure, during the first complete hematological and molecular remission (p = 0.002 and p = 0.0004, respectively). Conclusion. ALL with t(4; 11)/KMT2A-AFF1 was as an absolute indication for allo-HSCT in first remission, including children of < 1 year age group. Satisfactory results can be obtained with the use of haploidentical transplantation from the parents. This approach eliminates the search in the registers completely HLA-compatible donor and facilitates the treatment procedure.
Pomalidomide in Combination with Low-Dose Dexamethasone as the Treatment of "Double Refractory"
Authors: Petrov A.V. , Motorin D.V. , Pokrovskaya O.S. , Urnova E.S. , Nareiko M.V. , Babenetskaya D.V. , Alekseeva Yu.A. , Girshova L.L. , Mendeleeva L.P. , Zaritskii A.Yu.
Published: July 2017

Background. The development of radical therapy for multiple myeloma (MM) is still a pressing problem. This progressive disease requires repeated courses of therapy using drugs without cross-resistance. The prognosis of “double refractory” MM which is resistant to key antitumor drugs, first generation protease inhibitors and immunomodulating agents, remains poor. The median progression-free survival (PFS) and overall survival (OS) in this cohort of patients are 5 and 9 months, respectively. Aim. The aim was to assess the effectiveness and tolerability of pomalidomide in combination with low-dose of dexamethasone in “double refractory” relapsed/refractory multiple myeloma (RRMM). Materials & Methods. According to study protocol, 10 patients from Hematology Research Center and Federal Almazov North-West Medical Research Centre with RRMM were included in the period from September 2015 to July 2016. The median age was 62.5 years (range 48-76 years), and the median number of therapy lines was 4 (range 3-5). All patients had a disease progression after the administration of bortezomib, lenalidomide, and alkylating agents. In addition, 6 (60 %) of 10 patients received high-dose melphalan chemotherapy followed by auto-HSCT. The median number of therapy lines was 6 (range 4-15). Results. The overall response rate was 60 % and the minimum response (stabilization of the disease) was observed in 40 % of patients (IMWG criteria). The median PFS was 7.8 months; OS in 18 months was observed in 70 % of cases (the median not achieved). Treatment-associated grade III-IV hematologic toxicity was observed in 2 patients (5 episodes). Non-hematological adverse events of grade III-IV included acute coronary syndrome, deep vein thrombosis, neuropathic pain, and in 1 case acute delusional disorder, which required discontinuation of the therapy. The presence of initial cytopenia and renal failure before therapy with pomalidomide did not require the dosage reduction or discontinuation of treatment. Conclusion. Pomalidomide with low-dose dexamethasone demonstrated a high overall response rate an acceptable toxicity profile in patients with RRMM.
Thrombophilia and Pregnancy
Authors: Galaiko M.V. , Rybina O.V. , Litvinenko M.S. , Klimov Yu.V. , Al'tshuler B.Yu. , Gubkin A.V.
Published: July 2017

Background. Women with a predisposition to thrombosis (thrombophilia) during pregnancy develop pathological hypercoagulation, which can lead to early and late pregnancy losses. The most significant polymorphisms of thrombophilia genes include antithrombin III deficiency, protein C deficiency, Leiden mutation, hereditary hyperhomocysteinemia, and mutations of other clotting factors. In addition, several forms of thrombophilia are caused by hyperaggregation. Currently, heparin and its derivatives are considered the safest and most effective agents for the prevention and therapy of thrombosis. However, it is impossible to evaluate the efficacy of heparins using only standard methods (activated partial thromboplastin time, thrombin time, prothrombin time) and markers of intravascular coagulation activation (soluble fibrin-monomer complexes, D-dimer) due to their insufficient sensitivity. One of the new tests of qualitative and quantitative evaluation of the plasma coagulation system is thrombodynamics test, which allows to detect even minimal coagulation disturbances. Aim. The aim was to evaluate the use of the thrombodynamics test in women with first trimester pregnancy pathology. The authors aimed to show the high sensitivity of this test for the monitoring of treatment with low molecular weight heparins (LMWH). Methods. The study included 23 pregnant women with pregnancy pathology and/or history of thrombosis and threatening miscarriage in the first trimester. The women were aged 22-38 years (median age 30 years). The complex evaluation of the hemostatic system was performed using the thrombodynamics test. Results. LMWH therapy with the thrombodynamics monitoring was administered to 20 of 23 women. The statistically significant changes were observed only for thrombodynamics indices (p < 0.05). The total of 14 women delivered healthy children at 38-40 weeks (all patients received LMWH in the first trimester). Conclusion. The thrombodynamics test was the most reliable method of monitoring LMWH therapy, since it allows recording even minimal coagulation disturbances.
An overview of Osmotic Drug Delivery System: An update review
Authors: Patel Hiren J. , Parikh Vaishnavi P.
Published: July 2017

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.
PERFORMANS REPRODUKSI SAPI PERANAKAN ONGOLE DAN PERANAKAN LIMOUSIN DI KECAMATAN PADANG KABUPATEN LUMAJANG
Authors: Akriono Muhammad Luqman , Wahyuningsih Sri , Ihsan M Nur
Published: July 2017

The purpose of this research was conducted to evaluate reproductive performance of Ongolecrossbreed cattle andLimousin crossbreed Â inPadang, Lumajang Regency. The material used on this research were 50 heads of Limousin crossbreed cattle and 50 heads ofOngoleÂ crossbreed cattle.The method used in this research was purposive sampling survey.The data were analyzed by t-test unpaired on Service per Conception (S/C), Days Open (DO), Calving Interval (CI).Conception Rate (CR) and Fertility IndexÂ (FI)were analyzed by descriptive.The results showed thatS/C, DO, CR, CI and FI of Ongole crossbreed cattle were 1,42Â±0,70; 107,34Â±32,38days, 70%; 399,04Â±39,97 days;66,95and for Limousine crossbreed were 1,62Â±0,76; 107,34Â±32,38days, 52%; 416,04Â±44,09days;26,80, respectively. Â It was concluded that there was difference of reproductive performance between Ongole crossbreed cattle and Limousine crossbreedÂ  andÂ  reproductive performance of Ongole crossbreed cattle was better than Limousine crossbreed cattle.Â Keywords: Reproductive performance, Ongole crossbreed Cattle,Limousin crossbreed CattleÂ
JUMLAH LEUKOSIT DAN DIFFERENSIASI LEUKOSIT AYAM BROILER YANG DIBERI MINUM AIR REBUSAN KUNYIT
Authors: Jannah Prastiwanti Nur , Sugiharto Sugiharto , Isroli Isroli
Published: July 2017

This study aimed to assess the effect of boiled turmeric water on the number of leukocyte and differentiation leukocyte of broilers. The study was conducted in Oktober - November 2016. The material used was 200Day Old Chick Â (DOC) Â of broiler with initial weight 41.48 Â± 0.99 g. Feed used was a commercial feed with code B-11S to phase stater and BR-1AJ for the finisher phase and turmeric. The design used in this study was completely randomized design (CRD) with 5 treatments and 5 replicates containing 8 DOC in each. The treatment consisted of T0 (100% water), T1 (75% water + 25% boiled turmeric water), T2 (50% water + 50% boiled turmeric water), T3 (25% water + 75% boiled turmeric water), T4 (100% boiled turmeric water).The results showed that boiled turmeric water give significantly affect the percentage of lymphocytes and eosinophils (P<0,05), but did not significantly affect the total number of leukocytes, percentage of heterophile and monocytes (P>0,05). The conclusion from this study is that the boiled turmeric water in the drinking water of broilers was able to improve white blood profile, that indicated by the number of leukocyte and percentage of lymphocytes and eosinophils.Â Keywords: Turmeric, leuycocyte, differential leucocyte, broiler
Use of Proteomics To Investigate Kidney Function Decline over 5 Years
Authors: Carlsson Axel C. , Ingelsson Erik , Sundström Johan , Jesus Carrero Juan , Gustafsson Stefan , Feldreich Tobias , Stenemo Markus , Larsson Anders , Lind Lars , Ärnlöv Johan
Published: July 2017

Background and objectives

Using a discovery/replication approach, we investigated associations between a multiplex panel of 80 circulating proteins associated with cardiovascular pathology or inflammation, and eGFR decline per year and CKD incidence.

Design, setting, participants, & measurements

We used two cohorts, the Prospective Investigation of the Vasculature in Uppsala Seniors Study (PIVUS; n=687, mean age of 70 years, 51% women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=360 men, mean age of 78 years), with 5-year follow-up data on eGFR. There were 231 and 206 incident cases of CKD during follow-up in the PIVUS and ULSAM studies, respectively. Proteomic profiling of 80 proteins was assessed by a multiplex assay (proximity extension assay). The assay uses two antibodies for each protein and a PCR step to achieve a high-specific binding and the possibility to measure multiple proteins in parallel, but gives no absolute concentrations.

Results

In the discovery cohort from the PIVUS Study, 28 plasma proteins were significantly associated with eGFR decline per year, taking into account the multiple testing. Twenty of these proteins were significantly associated with eGFR decline per year in the replication cohort from the ULSAM Study after adjustment for age, sex, cardiovascular risk factors, medications, and urinary albumin-to-creatinine ratio (in order of significance: TNF-related apoptosis-inducing ligand receptor 2*, CD40L receptor, TNF receptor 1*, placenta growth factor*, thrombomodulin*, urokinase plasminogen activator surface receptor*, growth/differentiation factor 15*, macrophage colony-stimulating factor 1, fatty acid-binding protein*, cathepsin D, resistin, kallikrein 11*, C-C motif chemokine 3, proteinase-activated receptor 1*, cathepsin L, chitinase 3-like protein 1, TNF receptor 2*, fibroblast growth factor 23*, monocyte chemotactic protein 1, and kallikrein 6). Moreover, 11 of the proteins predicted CKD incidence (marked with * above). No protein consistently predicted eGFR decline per year independently of baseline eGFR in both cohorts.

Conclusions

Several circulating proteins involved in phosphate homeostasis, inflammation, apoptosis, extracellular matrix remodeling, angiogenesis, and endothelial dysfunction were associated with worsening kidney function. Multiplex proteomics appears to be a promising way of discovering novel aspects of kidney disease pathology.
The use of chitosan of Pomacea canaliculata shell as natural preservation to maintain fruit quality during storage process: Used as audio visual media of biotechnology learning
Authors: Trisnaningrum Yurike Fransischa , Wahyuni Sri , Rofieq Ainur
Published: July 2017

Chitosan merupakan turunan kitin yang terbentuk dari proses deasetilasi yang bisa digunakan sebagai bahan pengawet alami yang efektif dan memiliki aktivitas antimikroba.Penelitian ini bertujuan untuk mengetahui perbedaan kandungan vitamin C, pH dan berat dalam buah jeruk, strowberi, dan pisang yang diawetkan dengan chitosan cangkang keong mas selama proses penyimpanan danuntuk mengetahui berapakah konsentrasi chitosan cangkang keong mas yang paling efektif sebagai bahan pengawet buah. Penelitian merupakan True Experimental Research yang dilaksanakan di Laboratorium KimiaUniversitas Muhammadiyah Malang. Rancangan penelitian yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan 6 perlakuan dan 4 kali ulangan pada jeruk, strowberi dan pisang yaitu konsentrasi chitosan 1,5%, 2%, 2,5%, 3% dan 3,5%. Analisis data menggunakan analisis Blok Acak dan uji beda jarak nyata Duncan pada taraf signifikansi 0,05.Hasil penelitian menunjukkan ada pengaruh terhadap buah. Perubahan kandungan vitamin C dan berat paling kecil terjadi pada perlakuan 2,5% dan paling besar pada perlakuan kontrol. Pemberian konsentrasi chitosan cangkang keong mas2,5% yang paling efektif mempengaruhi kandungan vitamin C dan berat buah jeruk, strowberi dan pisang. Hasil penelitian diaplikasikan sebagai media audio visual dalam pembelajaran Bioteknologi
Submandibular gland sialolith of unusual size
Authors: Kandel Santosh , Pandey Bhuwan Raj , Poudel Prakash
Published: July 2017

Introduction: Sialolithiasis is the most common disease of the salivary glands. Majority of sialoliths occur in the submandibular gland and is a common cause of acute and chronic infections of the gland. The size varies from one mm to one cm. Size greater than 15 mm are considered unusual or giant sialolith.

Case report: We present a case of an unusual size sialolith of 16 mm in submandibular gland duct which was removed via transoral incision. The aim of presenting this case report is to understand etio-pathogenesis, clinical presentation and management of submandibular sialolithiasis.

Conclusion:  Submandicular sialolithiasis of more than 15 mm in size though rare are not uncommon. They can be managed intraorally if situated at or near the orifice.
Pengendalian Kualitas Kertas Dengan Menggunakan Statistical Process Control di Paper Machine 3
Authors: Devani Vera , Wahyuni Fitri
Published: July 2017

Purpose of this research is to determine types and causes of defects commonly found in Paper Machine 3 by using statistical process control (SPC) method.  Statistical process control (SPC) is a technique for solving problems and is used to monitor, control, analyze, manage and improve products and processes using statistical methods.  Based on Pareto Diagrams, wavy defect is found as the most frequent defect, which is 81.7%.  Human factor, meanwhile, is found as the main cause of defect, primarily due to lack of understanding on machinery and lack of training both leading to errors in data input.
Penyelesaian CCVRPTW Menggunakan Biased Random Key Genetic Algorithm-Populasi Degradasi
Authors: Christiana Listy Avri , Prasetyo Hari
Published: July 2017

The article presents the Biased Random Key Genetic Algorithm-Population Degradation (BRKGA-PD) design for completing Capacitated Closed Vehicle Routing Problem with Time Windows (CCVRPTW) on soft drink distributions that have been studied by Sembiring (2008). The goal is to determine some closed routes in meeting consumer demand with time limits and limit the capacity of vehicles used, so the total cost of distribution is minimal. The proposed algorithm adopts the extinction of population size. BRKGA-PD is coded using Matlab programming with the best parameter setting. The resulting solution is a subrute with a minimum of distribution fee. This algorithm is compared with two other methods, namely BRKGA general and heuristic methods. The results of this study can be concluded that the BRKGA-PD method is able to improve the general BRKGA because with a time difference that is not significant can provide cost savings of Rp. 6.857,- and BRKGA-PD is better than heuristic method because it can save more cost Rp. 87.000,-.
Moment Invariant Features Extraction for Hand Gesture Recognition of Sign Language based on SIBI
Authors: Rahagiyanto Angga , Basuki Achmad , Sigit Riyanto
Published: July 2017

Myo Armband became an immersive technology to help deaf people for communication each other. The problem on Myo sensor is unstable clock rate. It causes the different length data for the same period even on the same gesture. This research proposes Moment Invariant Method to extract the feature of sensor data from Myo. This method reduces the amount of data and makes the same length of data. This research is user-dependent, according to the characteristics of Myo Armband. The testing process was performed by using alphabet A to Z on SIBI, Indonesian Sign Language, with static and dynamic finger movements. There are 26 class of alphabets and 10 variants in each class. We use min-max normalization for guarantying the range of data. We use K-Nearest Neighbor method to classify dataset. Performance analysis with leave-one-out-validation method produced an accuracy of 82.31%. It requires a more advanced method of classification to improve the performance on the detection results.
REVIEW: Vital exposé, but it would have been better with more context
Authors: Cass Philip Leslie
Published: July 2017

Hit & Run, by Nicky Hager and Jon Stephenson. Nelson: Potter and Burton. 2017, 159 pages. ISBN ISBN 978-0-947-50339-0.HIT & RUN tells what happened when a small group of New Zealand SAS soldiers in Afghanistan decided to mount a revenge raid on two Afghan villages where they thought Taliban they believed had been responsible for the death of one of their own were staying. With Ministerial approval, relying on faulty intelligence and backed by American firepower, the SAS raided the villages of Naik and Khak Kuday Dad on the night of 22 August 2010. Their Taliban targets were nowhere to be found: They had slipped away into the mountains and were resting peacefully when the SAS arrived by helicopter in the middle of the night.
REVIEW: Noted: Questions of great intricacy opened up to non-Arabic audience
Authors: Cass Philip Leslie
Published: July 2017

Media and Political Contestation in the Contemporary Arab World, edited by Lena Jayyusi and Anne Sofie Roald. Basingstoke/New York: Palgrave MacMillan 2016. 327 pages. ISBN 978-1-137-5252-2-2.MEDIA and Political Contestation in the Contemporary Arab World explores the extremely complicated reality of the Arab media and its place in the political and cultural debates that are rarely recognised or understood in the west. In the Middle East, media of all kinds, from clothes to pop songs, carry heavily loaded political messages that simply cannot be avoided and which can cause political explosions.
Innovation as a determinant of the competitiveness of Polish enterprises
Authors: Sachpazidu-Wójcicka Karina
Published: July 2017

Research background: Global competition, fast and dynamic technological change and increasingly shorter product life cycles have changed the current environment of enterprises? functioning. In order to compete, firms are obliged to introduce new technologies, products, services or organizational systems and are forced to seek competitive advantages in innova-tiveness. Technology transfer becomes a major opportunity to enhance competitiveness and innovativeness of enterprises. The use of technology transfer and implementation of innova-tions allows companies to meet the requirements of the market and international competition. This paper discusses innovation activity occurring in industrial enterprises in Poland at present.Purpose of the article: The aim of the article is to determine the level of innovativeness in gaining the competitive position of surveyed Polish enterprises. The purpose of the article is to determine the occurring innovation activity and the novelty level of innovations implemented in the group of surveyed firms.Methods: The study is based on a survey on industrial firms (n=100) located in Poland. Data was collected during 100 individual interviews with high- and medium-level managers of randomly selected companies.Findings & Value added: The research has determined the level of innovativeness in gaining the competitive position of the surveyed firms. As the survey showed, enterprises prevailed the range of implementation of material innovation - product and process. Rarely firms implement non-material innovations. The study pointed to low activity in the field of patenting and implementing innovations with a high level of novelty. According to the obtained results, there is a dominant introducing new form the companies side innovations, which causes low competitiveness of surveyed enterprises. These findings suggest that measurement of innovativeness in gaining the competitiveness should be developed. The findings support the need for Polish enterprises to participate in advanced forms of technology and knowledge procurement.
Accuracy and repeatability of long-bone replicas of small animals fabricated by use of low-end and high-end commercial three-dimensional printers
Authors: Cone Jamie A. , Martin Thomas M. , Marcellin-Little Denis J. , Harrysson Ola L. A. , Griffith Emily H.
Published: July 2017

OBJECTIVE To assess the repeatability and accuracy of polymer replicas of small, medium, and large long bones of small animals fabricated by use of 2 low-end and 2 high-end 3-D printers.

SAMPLE Polymer replicas of a cat femur, dog radius, and dog tibia were fabricated in triplicate by use of each of four 3-D printing methods.

PROCEDURES 3-D renderings of the 3 bones reconstructed from CT images were prepared, and length, width of the proximal aspect, and width of the distal aspect of each CT image were measured in triplicate. Polymer replicas were fabricated by use of a high-end system that relied on jetting of curable liquid photopolymer, a high-end system that relied on polymer extrusion, a triple-nozzle polymer extrusion low-end system, and a dual-nozzle polymer extrusion low-end system. Polymer replicas were scanned by use of a laser-based coordinate measurement machine. Length, width of the proximal aspect, and width of the distal aspect of the scans of replicas were measured and compared with measurements for the 3-D renderings.

RESULTS 129 measurements were collected for 34 replicas (fabrication of 1 large long-bone replica was unsuccessful on each of the 2 low-end printers). Replicas were highly repeatable for all 3-D printers. The 3-D printers overestimated dimensions of large replicas by approximately 1%.

CONCLUSIONS AND CLINICAL RELEVANCE Low-end and high-end 3-D printers fabricated CT-derived replicas of bones of small animals with high repeatability. Replicas were slightly larger than the original bones.
Transnationalism and the Syrian Migrant Community: The Case of the 1925 Syrian Revolt
Authors: Bailony Reem
Published: July 2017

This article explores how the mahjar press of New York City engaged with the Syrian Revolt of 1925. Building upon Benedict Anderson’s well-known theories of imagined and long-distance nationalisms, as well as more recent debates on transnationalism, this article is part of a larger attempt to geographically decenter the study of the 1925 revolt in order to contribute to a better understanding of the ways in which nationalism and anti-colonialism were negotiated through a dialectical relationship between the homeland and the diaspora. It argues that divergent views of the revolt are better understood by framing its construction in the press in terms of: 1.) an expression of trans-border, and yet particular, loyalties, and 2.) a reflection of the diaspora’s ambiguous place in the new international order set up by the League of Nations.
ANTI HYPERLIPIDEMIC ACTIVITY OF SPONDIAS PINNATA FRUIT EXTRACTS
Authors: Raju N. J. , Pawar V. Santosh , Vishala T. Chandi
Published: July 2017

Hyperlipidemia is the greatest risk factor of coronary heart disease. Medicinal plants play a major role in hypolipidemic activity. Literature claims that Saponins are able to reduce hyperlipidemia. Based on high saponin content in herbal plants, Spondias pinnata (SP) was selected and the present study focus on the anti-hyperlipidemic activity of methanolic extracts of fruits of SP against Triton induced hyperlipidemia in rats. SP was administered at a dose of 100 and 200 mg/kg (p.o) to Triton induced hyperlipidemic rats. Fenofibrate was used as reference standard. The statistical analyses were carried out using one way ANOVA followed by Dunnet’s multiple comparisons test. The present investigation shows that all triton induced rats displayed hyperlipidemia as shown by their elevated levels of serum and liver cholesterol, triglyceride, PL, VLDL, LDL and the reduction in the HDL level. It can be concluded that SP 100 and 200 mg/kg treatment was effective in cholesterol, PL, TG, VLDL, LDL and HDL in a dose dependant manner.
Management of pelvic chondrosarcoma
Authors: Groșeanu Florin , Popescu Roman , Cuculici Stefan , Popescu Mihai V. , Ștefan Cristea
Published: July 2017

The partial or complete excision of the hemipelvis with sparing of the lower limb is an option of the treatment of pelvic chondrosarcoma and a therapeutic alternative of the interilio-abdominal disarticulation. The operation has in principle the same indications as the interilio-abdominal disarticulation and offers a good solution for avoiding a mutilating operation. The 149 cases include: 120 biopsies, 29 excisional biopsies, 6 interilio-abdominal disarticulations and 14 resections – reconstruction’s, one of with prosthetic reconstruction. The prognostic score was established by assessing: the surgical stage, the site of the tumor, the surgical margins of the tumor, the functional mobility and the postoperative activity. The wide excision of the tumor, a stable reconstruction and an efficient recovery are essential for a successful treatment of pelvic chondrosarcoma. The limb sparing resection-reconstruction represents a highly surgical demanding procedure, followed up by complications in 60% of the cases, so that should be performed only by high skilled surgeons. Hemipelvectomy still remains a well-established life-saving surgery method for patients suffering from vast oncological extensions, where a pelvic resection is not an option.
Atypical olfactory groove meningioma associated with uterine fibromatosis; case report
Authors: Papacocea Toma I. , Adam Danil , Renta Mirela , Papacocea Ioana R.
Published: July 2017

The concomitant presence of the olfactory groove meningioma with uterine fibrosis is very rare. Our report presents the case of a giant olfactory groove meningioma revealed after a uterine fibroma resection in a 44 years-old female, due to a generalized seizure 10 days after operation. Cranial CT-scan identified the tumor as an olfactory groove meningioma. The tumor was operated with a macroscopically complete resection; the endothermal coagulation of the dura attachment was performed (Simpson II) with a good postoperative evolution. Laboratory results showed the presence of receptors for steroid hormones both in meningioma and uterine tumor, and the histopathological examination revealed an atypical meningioma with 17% proliferation markers. Our findings suggest that even though meningiomas are benign tumors and a complete resection usually indicates a good prognosis, the association with uterine fibromatosis and the presence of high percentage of steroid receptors creates a higher risk to relapse, imposing therefore a good monitoring.
Effect of Egg Consumption on Serum Lipid Profile in Young Adults
Authors: Nargis S , Majumder M , Debnath BC , Hossain MS
Published: July 2017

Egg is an easily available, inexpensive and a major source of proteins, fats, vitamins and minerals, but its cholesterol content is high (about 200 mg per egg) and it is frequently blamed for atherosclerosis with consequent cardiovascular diseases. Eggs are very popular to young people and parents are always concerned with their daily consumption. The aim of the study was to evaluate the effect of consumption of eggs on serum lipid profile of healthy young adults. It was a prospective comparative study carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College, during the period from January to December, 2014. Eighty (80) non-diabetic, normotensive healthy young adults of 18-30 years of age were enrolled as study population. Among them 40 randomly selected subjects consumed one egg/day (Intervention group) and 40 subjects did not consume egg for 4 weeks' study period (Control group). Baseline BMI, BP, fasting blood glucose and lipid profile were estimated. After 4 weeks, lipid profile was estimated in each group. Informed written consent was taken from each participant. Permission was taken from Ethical Committee of the Institute. Data were analyzed by SPSS. Chi-square test, unpaired and paired 't' test were done. In the intervention group, serum total cholesterol (TC) and LDL cholesterol (LDL-C) significantly decreased at the end of 4th week, but serum HDL cholesterol (HDL-C) and serum triglyceride (TG) did not differ significantly from baseline. In control group, serum HDL-C significantly decreased at the end of 4th week but serum TC, LDL-C and TG did not differ significantly. It may be concluded that daily consumption of one egg does not unfavorably influence on lipid profile in young adults. Further studies with larger sample size with and without risk factors may be conducted on middle and old age subjects.Bangladesh J Med Biochem 2015; 8(1): 05-09
XNA
Authors: Asad HB , Akhter S
Published: July 2017

Abstract not availableBangladesh J Med Biochem 2015; 8(2): 40-41
Status of Serum Copper and Zinc in Pre-Eclampsia
Authors: Muna FZ , Sirazi ASMM , Majumder M , Serajuddin K , Debnath BC , Hossain MS
Published: July 2017

Pre-eclampsia is a multisystem and multifactorial disease that affects both mother and fetus by endothelial dysfunction and intrauterine growth retardation. It is thought that pre-eclampsia is associated with an imbalance of increased lipid peroxides and decreased antioxidants. Dietary deficiency or excess of copper, zinc or other micronutrients play important role in the pathogenesis of pre-eclampsia because nutrients can modulate oxidative stress by increasing or decreasing free radicals or antioxidants and providing substrates for formation of free radicals.This study was carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College during the period from July 2014 to June 2015 to evaluate the status of serum copper and zinc in pre-eclamptic patients. For this study 85 age-matched women were selected and grouped as 30 pre-eclamptic patients, 27 normal pregnant and 28 nonpregnant women. serum copper and zinc level were measured in all study subjects by AAS. Data were analyzed with the help of SPSS version 17.0. Mean (±SD) level of serum copper and zinc were 1.43±0.49 mg/l and 2.43±2.89 mg/l in pre-eclamptics, while in normal pregnant women the levels were 1.51±0.47 mg/l and 2.87±2.23 mg/l and in non-pregnant women these were 0.85±0.28 mg/l and 3.70±2.61 mg/l respectively. Serum copper significantly increased in pre-eclamptics and normal pregnant women when compared with that of non-pregnant women [F (2, 82) =19.763; p<0.001], but there was no significant difference between pre-eclamptic and normal pregnant group. No significant difference of serum zinc among three groups were observed [F (2, 82) =1.774; p=0.176]. The study showed increased trend of serum copper and decreased trend of serum zinc in pregnancy (both preeclampsia and without pre-eclampsia) compared with non-pregnant women, and both were reduced in pre-eclampsia compared to normal pregnancy. As our study did not show any significant difference in copper and zinc level in pre-eclamptics and normal pregnant women hence it can be concluded that there may not be any significant association of serum copper and zinc level with pre-eclampsia.Bangladesh J Med Biochem 2015; 8(2): 49-54