bluuebunny/crossref_metadata_2025 huggingface dataset:
3D Slicer open-source software plug-in for vector-based angle calculation of canine hind limb alignment in computed tomographic images
Authors: Burg-Personnaz Juliette , Zöllner Martin , Reese Sven , Meyer-Lindenberg Andrea , Brühschwein Andreas
Published: March 2024

Background

Severe and complex angular limb deformities in dogs require accurate morphological assessment using diagnostic imaging to achieve successful orthopedic surgery. Computed tomography (CT) is commonly used to overcome projection errors in two-dimensional angular measurements of dog hindlimb alignment. Three-dimensional volume rendering (VR) techniques permit virtual positioning and variable projection, but the final CT-image that defines the projection plane for angular measurements remains two-dimensional.

Objective

We wanted to develop a true three-dimensional open-source technique to measure the alignments of the hind limbs of dogs in CT scanners.

Methods

We developed an open-source 3D Slicer plug-in, to perform angular measurements using vector calculations in three-dimensional space. In 113 CT-scans of canine pelvic limbs, femoral torsion, femoral varus, femorotibial rotation, tibial torsion, tibial varus and tibiotalar rotation angles were calculated and compared to an already validated technique using VoXim®.

Results

Reference points were identified and measurements were possible in the 113 acquisitions. The greatest difference between the two techniques was 1.4° at only one tibial torsion angle. Mean values for all Bland-Altman plots did not show significant differences and were less than 0.07° for all comparisons.

Discussion

Based on these results we considered angular measurements of canine hind limb alignment in CT scans using the 3D Slicer extension program sufficiently accurate for clinical orthopedic and surgical purposes in veterinary medicine.

Conclusion

With our open-source 3D Slicer extension software, we provide a free accessible tool for veterinary orthopedic surgeons and thus we hope to improve angular measurements in CT-scans of canine hind limb deformities through true three-dimensionality.
Position-specific workload of professional rugby union players during tactical periodization training
Authors: Hu Xiaopan , Boisbluche Simon , Philippe Kilian , Maurelli Olivier , Ren Xiangyu , Li Shichang , Xu Bo , Prioux Jacques
Published: March 2024

The positional workload characteristics in rugby union on three acquisition days (i.e. strength, endurance, and speed days) of tactical periodization are still relatively unknown. Therefore, the primary aim of this study was to shed light on the positional external workload variables (10 Hz Global Positioning System and accelerometer microtechnology) and internal workload indicators (the session rating of perceived exertion) of players in a professional rugby union team by utilizing and comparing two tactical periodization models. Twenty-six male players (15 forwards and 11 backs) were recruited from a French second-division rugby club. Data were obtained over 10 weeks of in-season home games: a total of 780 observations were analyzed. Student’s t-test observed different external workload profiles between positions among acquisition days. Mean external workload values, except PlayerLoadslow, were significantly higher (p≤0.01; effect size: 0.41–1.93) for backs than forwards for all acquisition days. Moreover, forwards perceived a higher internal workload than backs on the strength day of both models. The findings demonstrate that applying these two tactical periodization models could result in effective rugby union training. Validating external and internal workload characteristics on tactical periodization acquisition days enables extensive analysis of training load monitoring data; these data can be utilized to discover the unique characteristics of each position and design position-specific acquisition days to improve performance.
Bicyclomycin generates ROS and blocks cell division in Escherichia coli
Authors: Prakash Anand , Dutta Dipak
Published: March 2024

The role of reactive oxygen species (ROS) in the killing exerted by antibiotics on bacteria is debated. Evidence attributes part of toxicity of many antibiotics to their ability to generate ROS by interfering with cellular metabolism, but some studies dismiss the role of ROS. Bicyclomycin (BCM) is a broad-spectrum antibiotic that is the only known compound to inhibit E. coli transcription terminator factor Rho with no known other cellular targets. In the present study, we addressed this question by checking whether the induction of oxidative stress could explain the increased sensitivity to Bicyclomycin in the hns deleted strain even in Δkil background in E. coli. BCM evoked the generation of ROS in E. coli cells. BCM is known to cause the cell filamentation phenotype in E. coli. Performing fluorescence microscopic analysis, we show that bicyclomycin-dependent cell filamentation is associated with SOS response. RecA-GFP filaments were found to colocalize with the damaged DNA sites in the cell. Further analysis revealed that the genomic DNA was partitioned but the cell septum formation was severely affected under BCM treatment. Furthermore, we observed biofilm formation by E. coli after BCM treatment. We hypothesize that ROS production after BCM treatment could lead to cell filamentation in bacteria. A better understanding of the mode of toxicity of BCM will help us design better antibiotic treatment regimes for clinical practices, including combinatorial drug therapies. The cell filamentation phenotype observed after BCM treatment makes this antibiotic a promising drug for phage-antibiotic synergy (PAS) therapy.
Regional gap and sustainable development of interpreting level in mainland China: A statistics and GIS-based study
Authors: Xu Tianyuan , Xue Ling , Xiang Hengxing
Published: March 2024

Against the backdrop of globalization, interpreting, a translation communicative activity in a verbal way, plays an increasingly important role in international communications and exchanges. In response to this world pattern, the Chinese government attaches great importance to the interpreting industry. However, due to the national condition of uneven regional development, the English interpreting level across China is also unbalanced. Confronting this circumstance, previous research only stagnates at the level of recognizing the problem, but very few studies have attempted to solve the problem. Thus, the current study aims to figure out the regional interpreting level in mainland China by establishing and utilizing an innovative indicator system based on statistics and geography technologies. Based on the literature review and empirical questionnaire survey from different stakeholders, the study proposes an indicator system containing 3 first-level factors and 7 second-level factors to measure regional English interpreting levels. The weight of each indicator and scoring method is laid down based on factor analysis and interval marking. In addition, putting the innovative indicator system into practice, a total of 38 groups of regional data are collected to rank the regional interpreting level across China. Integrating with GIS and statistical techniques, the result visually shows that the English interpreting level across China is uneven at present: higher in the southern and eastern parts of China compared to that of northern and western China, which is unfriendly to sustainable development in the future. Facing this reality, a following-up analysis has been made for offering explanations of the results and suggestions for regional interpreting sustainable development.
An immunochromatographic strip sensor for marbofloxacin residues
Authors: Yang Xingdong , Li Qingmei , Kwee Sharon , Yang Jifei , Zhang Qianqian , Hu Xiaofei
Published: March 2024

Marbofloxacin (MBF) was once widely used as a veterinary drug to control diseases in animals. MBF residues in animal food endanger human health. In the present study, an immunochromatographic strip assay (ICSA) utilizing a competitive principle was developed to rapidly detect MBF in beef samples. The 50% inhibitory concentration (IC50) and the limit of detection (LOD) of the ICSAs were 2.5 ng/mL and 0.5 ng/mL, respectively. The cross-reactivity (CR) of the MBF ICSAs to Ofloxacin (OFL), enrofloxacin (ENR), norfloxacin (NOR), and Ciprofloxacin (CIP) were 60.98%, 32.05%, 22.94%, and 23.58%, respectively. The CR for difloxacin (DIF) and sarafloxacin (SAR) was less than 0.1%. The recovery rates of MBF in spiked beef samples ranged from 82.0% to 90.4%. The intra-assay and interassay coefficients of variation (CVs) were below 10%. In addition, when the same authentic beef samples were detected in a side-by-side comparison between the ICSAs and HPLC‒MS, no statistically significant difference was observed. Therefore, the proposed ICSAs can be a useful tool for monitoring MBF residues in beef samples in a qualitative and quantitative manner.
Longitudinal development and tracking of cardiorespiratory fitness from childhood to adolescence
Authors: Ingvarsdottir Thuridur Helga , Johannsson Erlingur , Rognvaldsdottir Vaka , Stefansdottir Runa Sif , Arnardottir Nanna Yr
Published: March 2024

Background

Cardiorespiratory fitness (CRF) is an important indicator of health in childhood and adolescence but longitudinal studies on the development and tracking of CRF from childhood to adolescence are scarce.

Objectives

The objectives of this study were (1) to assess longitudinal development and track CRF over 10 years from childhood to adolescence, and (2) to examine potential sex differences in the development and tracking of CRF during this period.

Methods

Participants were Icelandic children born in 1999, measured at the age of 7 (n = 190, 106 girls), 9 (n = 163, 95 girls), 15 (n = 239, 134 girls), and 17 (n = 202, 119 girls). CRF was assessed with a maximal cycle ergometer test and expressed as maximal power output (Max W) and maximal power output relative to lean mass (W/kgLM). Multilevel regression models were used to study the longitudinal development of CRF, and tracking was assessed with Spearman’s rank correlation, logistic regression, and the percentage of participants remaining in low, moderate, or high CRF categories between measurements.

Results

Max W and W/kgLM increased for both boys and girls up to age 15. Max W plateaued for both boys and girls while W/kgLM plateaued for girls but declined for boys from age 15 to 17. Boys had higher Max W than girls from age 15 and higher W/kgLM from age 9. CRF tracked at low to moderate levels from childhood to adolescence and at high levels in adolescence, with higher values observed for boys than girls.

Conclusions

Age 15 was a critical time point in the development of CRF, with values starting to plateau for girls and decline for boys. The results support early intervention for improved CRF in later years, with interventions targeting all children, regardless of their CRF level.
Exploring the impact of college graduates’ place attachment on entrepreneurial intention upon returning to hometowns: A study based on the theory of planned behavior
Authors: Lv Cixian , Xu Jingjing , Chang Wenhao , Zhi Xiaotong , Yang Peijin , Wang Xinghua
Published: March 2024

The issue of the continuing decline of rural areas caused by urbanization has become a global concern. Encouraging college graduates to return to their hometowns to start businesses is an important initiative for countries to achieve sustainable rural development. Drawing from the Theory of Planned Behavior (TPB), this study introduces two additional variables: place attachment and entrepreneurial self-efficacy. Through a series of three model refinements, a comprehensive theoretical framework has been formulated to elucidate Chinese college graduates’ hometown-based entrepreneurial intention and behavior. The samples for this study were 1151 college graduates selected from diverse universities across China. This study aims to explore the influence of college graduates’ hometown-based entrepreneurial intention using Structural Equation Modelling. This analytical approach illuminates how variables such as college graduates’ place attachment, entrepreneurial self-efficacy, subjective norm for hometown-based entrepreneurship, and attitude towards hometown-based entrepreneurship affected their hometown-based entrepreneurial intention. The research findings reveal the following insights: (1) The overall levels of college graduates’ place attachment and hometown-based entrepreneurial intention were relatively low. (2) College graduates’ place attachment, entrepreneurial self-efficacy, subjective norm for hometown-based entrepreneurship, and attitude towards hometown-based entrepreneurship, had a positive impact on their hometown-based entrepreneurial intention. (3) College graduates’ place attachment and subjective norm for hometown-based entrepreneurship had a significant impact on their hometown-based entrepreneurial intention through the mediating variable of entrepreneurial self-efficacy. This study then makes policy recommendations from theoretical and managerial aspects.
Young carers’ experiences of services and support: What is helpful and how can support be improved?
Authors: Stevens Madeleine , Brimblecombe Nicola , Gowen Sara , Skyer Robin , Moriarty Jo
Published: March 2024

Globally, many children and young people provide support to family members who have poor physical or mental health, are disabled, or misuse drugs and alcohol. These young carers are at higher risk of poorer education, employment, health, and social participation outcomes compared to their peers without caring responsibilities. In the UK, awareness of the challenges faced by young carers, and a framework of their legal rights, are relatively well-developed. However, it is unclear how support can most effectively be provided. Taking a qualitative approach we explored experiences and views of young carers (aged 9–25), conducting focus groups or interviews with 133 young carers and 17 parent care recipients. We explored what aspects of services and support are seen as helpful, valued, and acceptable to young people, and what could be improved. A reflexive, thematic analysis was conducted. Valued support came from: young carers groups (including peer support), school-based and mental health support, and support for the care recipient. Helpful aspects of support included someone who listens and understands, and can be trusted not to break confidentiality; involving the young person in information, decision-making and planning (sometimes including regarding the care recipient); and finding and linking to other services. There was a difficult balance for practitioners between being perceived as proactive, persistent or intrusive when offering support to a young carer, but it was important to allow opportunities for young carers, and those they care for, to change their minds about when and whether to access support. Many interactions were perceived as unhelpful or threatening to the family, and there was often not enough of the type of support that was valued. Sharing of positive experiences can be beneficial for both people seeking support and those delivering it; key messages on what is helpful from the perspective of young carers can help support and shape practice approaches.
The psychological burden of NMOSD – a mixed method study of patients and caregivers
Authors: Esiason Darcy C. , Ciesinski Nicole , Nurse Chelsi N. , Erler Wendy , Hattrich Tom , Deshpande Ankita , Virginia O’Hayer C.
Published: March 2024

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disorder of the central nervous system with common symptoms of rapid onset of eye pain, loss of vision, neck/back pain, paralysis, bowel and bladder dysfunction and heat sensitivity. The rare, unpredictable, and debilitating nature of NMOSD constitutes a unique psychological burden for patients and their caregivers, the specific nature and extent of which is not yet known. This mixed methods study, informed by both quantitative and qualitative data collected via self-report measures, focus groups, and in-depth interviews, aims to investigate and understand the psychological burden of patients with NMOSD and their caregiver/loved ones, so as to inform a specialized intervention. 31 adults living with NMOSD and 22 caregivers of people with NMOSD in the United States and Canada, recruited from NMOSD patient advocacy groups, social media groups, and through word of mouth from other participants, completed a battery of standardized self-report measures of anxiety, depression, trauma, cognitive fusion, valued living, and coping styles. Semi-structured focus group sessions were conducted via HIPAA-compliant Zoom with 31 patients, and separate focus groups were conducted with 22 caregivers. A subset of these samples, comprised of 16 patients and 11 caregivers, participated in individual semi-structured interviews, prioritizing inclusion of diverse perspectives. Descriptive statistics and bivariate correlations were run on quantitative self-report data using SPSS [Version 28.0.1]; data were stored in REDCap. Reflexive thematic analysis was employed regarding qualitative individual interview data. The majority of patients reported experiencing anxiety, depression, cognitive fusion, over-controlled coping, and lack of values-based living. Caregivers also reported heightened anxiety, cognitive fusion, and over-controlled coping, although they did not endorse clinically significant depression. Patient and caregiver degree of anxiety and of overcontrolled coping were both strongly positively correlated, likely affecting how both parties manage NMOSD-related stressors, both individually and as a dyad. Patients reported more anxiety, depression, psychological inflexibility, and lack of values-based living, compared with caregivers. Patient and caregiver narrative themes included mistrust of medical professionals, lack of support immediately following diagnosis, changes in relationships, deviation from values-based living, internalization of feelings, and avoidant coping strategies to manage the psychological burden of NMOSD. A novel mental health intervention targeting the specific psychological burden of life with NMOSD is proposed.
The epidemiology of gestational diabetes, gestation hypertension, and anemia in North Palestine from 2018 to 2020: A retrospective study
Authors: Damiri Basma , Abumohsen Haytham , BelKebir Souad , Hamdan Mahmoud , Saudi Lubna , Hindi Hiba , Abdaldaem Rawnaq , Bustami Baraa , Almusleh Abeer , Yasin Osama
Published: March 2024

Background

In Palestine, women face a challenging environment and a demanding lifestyle, which puts them at a higher risk of experiencing complications during pregnancy. This study aimed to examine the risk factors linked with abnormal hemoglobin (Hb) levels, gestational diabetes (GD), and gestational hypertension (GH) among pregnant women. The results was compared between women residing in cities or villages areas and those in refugee camps.

Methods

Medical records (N = 7889) for pregnant women at primary healthcare centers in the North West Bank were reviewed for sociodemographic and medical data along with the reported fasting blood sugar, hemoglobin, and blood pressure in the first and second trimesters from July 2018 to July 2020. However, only 6640 were included in the analysis as 1249 were excluded for having multiple pregnancy or lost to follow up. Complications and risk factors were defined according to the available global guidelines. Then, descriptive analysis was used to show the percentages of different risk factors and complications among them. The correlation between the several characteristics and variables with these complications was assessed by calculating the odds ratios (OR) using logistic regression. P-values of <0.05 were considered significant.

Results

The prevalence of adolescent pregnancy was the highest among women living in rural areas (9.8%) and grand multigravidity among refugee women (22%). The overall prevalence of anemia was higher in the second-trimester (16.2%) than in the first-trimester (11.2%), with anemic women in the first-trimester being more likely to be anemic in the second-trimester (OR = 8.223, P-value<0.001). Although anemia was less common in the first-trimester among refugees than among women living in urban areas (OR = 0.768, P-value = 0.006), it was more prevalent in the second-trimester (OR = 1.352, P-value<0.001). Moreover, refugee women were at lower risk than women living in urban areas of having GD (OR = 0.687, P-value<0.001) and diabetes mellitus (OR = 0.472, P-value<0.001) in the second-trimester. GH was associated with GD (OR = 1.401, P-value = 0.003) and DM (OR = 1.966, P-value<0.001).

Conclusion

The findings of this study provide evidence-based data on the considerable prevalence of pregnancy complications, anemia, GD, and GH among Palestinian pregnant women living in the north of the West Bank. Multi gravida, gestational age, Hb levels, and the type of settings were strong predictors of pregnancy complications. Therefore, a national plan is needed to ensure adequate maternal care for all, especially disadvantaged women, those in rural areas and refugee camps.
Activación Rural mediante Festivales de Arte. Precariedad y Prestigio: XIX Edición de Arte En La Tierra (Santa Lucía de Ocón)
Authors: Moreno-Domínguez Sofía
Published: March 2024

Este artículo analiza los procesos de activación rural en el marco del festival de arte ambiental o Land Art «Arte en la Tierra», en Santa Lucía de Ocón (La Rioja), nacido de la mano de los artistas Félix Reyes y Rosa Castellot en 2003. Desde la década de 1960 han surgido conceptos en torno a lo neorrural o prorrural que se han visto reforzados por acciones culturales y artísticas como festivales en localidades con baja densidad poblacional. Tras hacer un rastreo por algunos de estos ejemplos insertados en el mapeo de Cultura y Ruralidades del Ministerio de Cultura de 2023, nos centramos en el caso de estudio de la XIX edición «Arte en la Tierra» donde pude colaborar en la elaboración de un mapa sonoro de la intervención del artista Carlos Ramírez de la Concepción «Zorromono». Su proyecto UMBRAL ocupó siete espacios patrimoniales de Santa Lucía de Ocón en la primera semana de agosto de 2022. En paralelo archivé 49 testimonios de la vecindad local, quienes acompañaron en el proceso creativo durante dicha semana estival. Como colaboradora recogí las memorias sobre los lugares intervenidos por el artista y los vertí en la plataforma Bandcamp. Este trabajo propone acciones que usan el arte y la cultura como agentes mediadores a través de la participación ciudadana para lograr el arraigo en los territorios.
¡Aquí no hay quien viva! El éxito electoral de las candidaturas de la España vacía
Authors: Sánchez-García Álvaro , Delgado-García Maria
Published: March 2024

Este artículo aborda, desde un punto de vista electoralista, un tema en pleno auge: la España vaciada. Tomamos Teruel Existe! y Soria ¡Ya! como selección de caso, al ser estas las únicas candidaturas de la Plataforma de la España Vaciada que han conseguido representación parlamentaria. Adoptando una perspectiva exploratoria, tratamos de conocer cuáles fueron los factores que a nivel municipal influyeron sobre el éxito de las Candidaturas de la España Vaciada (CEV). Para abordar esta cuestión empleamos una metodología combinada. Primero, realizamos un análisis clúster que nos permite clasificar los municipios en función de su naturaleza. Seguidamente, mediante un modelo de regresión lineal exploramos cuáles de estas características influyeron en el rendimiento electoral de las CEV. Los resultados muestran que estas formaciones cosechan el éxito en municipios cercanos a las capitales de provincia, con un tamaño superior a la media y con una reducida presencia de desempleados. No obstante, el factor que muestra tener un mayor peso en todo el trabajo fue la realización de actos políticos durante la campaña electoral.
Korrika, nortasun kolektiboaren eraikuntzarako: #korrika22-ren aztarna digitalaren azterketa
Authors: Orbegozo Terradillos Julen , Zarrabeitia Bilbao Enara , Larrondo Ureta Ainara , Alvarez Meaza Izaskun
Published: March 2024

Korrika euskara bezalako hizkuntza gutxitu baten aldeko ekimen herrikoi eta parte-hartzaileena da. Euskaltzaleek 2.000 kilometro inguru egiten dituzte txandaka hamaika egunez, etenik gabe. Ikerketa lan honek 22. Korrika digitala aztertzen du Twitterren, COVID 19-ak eragindako pandemiaren ondoren egindako lehena, Sare Sozialen Analisia eta Edukiaren Azterketa Deskriptiboa konbinatuz. 13.739 ziberaktibisten 52.210 txio kapturatu eta aztertzen dira (2022ko martxoaren 1etik apirilaren 30era), eta elkarrizketako liderrei, erabilitako hizkuntzari, eduki biralizatuenei eta abarrei buruz informazioa erauzten da. Emaitzek erakusten dute zibernauten komunitatea digitalki mobilizatzen dela ekitaldi fisikoarekin batera, eta Korrika digitalak izaera horizontal eta kohesionatu bat sortzen duela, lidergo partekatuekin eta hainbat hizkuntza erabiliz hizkuntza gutxituekiko sentsibilizatutako nazioarteko beste komunitate batzuekiko harreman aktibistak sustatzeko. Bestalde, eduki biralizatuenak ikus-entzunezko formatuzkoak dira, eta metafora bisualekin euskal nortasun kolektiboa eraikitzen laguntzen dute, esfortzuarekin, erromantizismoarekin, ausardiarekin, lankidetzaren eta antzeko baloreei erreferentzia eginda. Beste fenomeno nabarmen bat da elkarrizketa, nagusiki, mezu eta sinbolo positiboen inguruan garatzen dela, eta komunitate zibernautak modu eraginkorrean isolatzen dituela gorroto-diskurtsoen zantzuak. Ikerketa honen diseinu metodologikoa beste fenomeno sozial batzuk aztertzeko baliatu dezake komunitate zientifikoak, datua (Twitterreko interakzioak) ezagutza bihurtzen baitu. Hala nola, interpelatutako eragileek ere antzeko ikerketak egin ditzakete erabaki estrategikoak hartzeko.
Existential concerns and supports. An investigation into vulnerability
Authors: Santiago Jose
Published: March 2024

Within the framework of the defence of a sociology of the relationship to the world, this article seeks to analyse the existential discomforts and concerns experienced by individuals in situations of vulnerability, as well as the socio-existential supports that enable them to sustain themselves when the support of work is lost or weakened. To this end, the article mobilises empirical material from research carried out through in-depth interviews and discussion and feedback groups. Specifically, this research focuses on three groups: young people, unemployed people aged over 45, and family network women carers, all of them in a situation of vulnerability. We offer a differentiated analysis of the main existential discomforts and concerns experienced by each of these groups, as well as the main socio-existential supports that allow them to sustain themselves in their daily lives. This article thus aims to make a theoretical and empirical contribution to the development of both a sociology of the relationship to the world and a sociology of supports.
España vacía, España vaciada: las dimensiones de identidad y simbólicas de las regiones periféricas. Un marco territorial
Authors: Andrés Cabello Sergio
Published: March 2024

El presente monográfico de Papeles del CEIC, bajo el título de «España vacía, España vaciada: las dimensiones de identidad y simbólicas de las regiones periféricas», responde al interés que han ido ganando las cuestiones vinculadas a los debates territoriales, que cuentan con derivadas en diferentes áreas, desde las propias de la identidad hasta las materiales, pasando por el papel de las propias políticas públicas, así como por la construcción de relatos y discursos vinculados a los territorios. El número presenta las contribuciones de Manuel Ahedo, Jaime Escribano Pizarro, Jaume Pla-Bañuls y Néstor Vercher Savall, Álvaro Sánchez-García y María Delgado-García, Enric Castelló, Ángel Martín Gómez, Natalia Arcajo Fuentes, Israel Gómez Rodilla y Sara Galindo Pérez, y Sofía Moreno-Domínguez, a lo que se le suma —en la sección Papeles Críticos— el trabajo de Nahir Valentina Jiménez Rojas.
Notable mutations of porcine parvovirus 1 and 4 circulating in commercial pig farms in South Korea
Authors: Park Beom Soo , Hong Jihyeon , Jun Jongsu , Choi An Kook , Park Choi Kyu , Lyoo Young Soo
Published: March 2024

In this study, almost complete genomic sequences of PPV1 and PPV4 circulating in commercial pig farms in South Korea were obtained and analyzed. Important mutations that may be precursors to host changes, such as premature stop codons of PPV1 and frameshift mutations of PPV4, were observed in these sequences. A 27a-like strain of PPV1, known to show a lack of cross-neutralization against existing commercial vaccine strains, was identified by phylogenetic analysis. Given the active genetic evolution, the additional precursors to host changes and emerging new genotypes of PPVs need to be monitored through continuous sampling and genetic analysis.
Pneumonia caused by Neisseria animaloris in a cat
Authors: Jeong Soo-Yeon , Cheon Doo-Sung , Park Chul
Published: March 2024

Neisseria animaloris is a common flora in animals, but its pathogenicity is rarely reported. In this case report, N. animaloris was isolated from a hospitalized cat with pneumonia. The cat was discharged after testing and treatment with appropriate antibiotics. This paper reports the first case of N. animaloris pneumonia in Korea.
Protective effect of platelet-rich plasma against cold ischemia-induced apoptosis of canine adipose-derived mesenchymal stem cells
Authors: Shin Suji , Kim Sung-Eon , An Seong-Won , Jeong Seong-Mok , Kwon Young-Sam
Published: March 2024

This study was performed to assess the antiapoptotic effect of canine platelet-rich plasma (PRP) treated on the canine adipose-derived mesenchymal stem cells (cMSCs) under cold ischemic conditions. The effect of preventing apoptosis of cMSCs was evaluated in the apoptotic condition induced by cold ischemic injury in vitro. To determine the progression of apoptosis, the changes in cell nucleus were observed using 4',6-diamidino-2-phenylindole (DAPI) fluorescence staining. In addition, we examined the mitochondrial membrane potential (MMP) and caspase-3 activity. When the cold hypoxic injury was applied to cMSCs, the apoptotic change was observed by DAPI staining, mitochondrial staining for MMP, and caspase-3 assay. PRP significantly decreased the number of apoptotic cells. Nuclear shrinkage and fragmentation of apoptotic cells in control groups were observed by DAPI staining. The MMP was recovered by the treatment of PRP. In addition, when the luminescence intensity was measured for caspase-3 activity, the value was significantly higher in the PRP treated groups than the control groups. The results of this study showed that the PRP may have a beneficial effect on apoptosis induced by cold ischemic injury.
Incidence of canine viral diseases and prevalence of virus neutralization antibodies of canine distemper virus, adenovirus type 2, parvovirus, and parainfluenza virus type 5 in Korean dogs
Authors: Yang Dong-Kun , Kim Ha-Hyun , Lee Hye Jeong , Cheong Young-Ju , Hyun Lee-Sang , Kim Minuk , Hyun Bang-Hun
Published: March 2024

Canine distemper virus (CDV), canine adenovirus type 2 (CAV-2), canine parvovirus (CPV), and canine parainfluenza virus 5 (CPIV-5) are the major viral pathogens in dogs. Despite the availability of vaccines for dogs against these four viral pathogens, investigations of antibodies against these pathogens have rarely been reported in South Korea. In this study, we investigated the recent incidence of viral diseases in dogs and conducted sero-surveillance for CDV, CAV-2, CPV, and CPIV-5 in Korean dogs. The most frequently diagnosed canine viral disease in Korean dog samples from 2000 to 2022 was CPV infection, which accounted for 48.7% (464/953) of the cases. A total of 400 dog serum samples collected between 2019 and 2022 were screened for the presence of virus-neutralizing antibodies against CDV, CAV-2, CPV, and CPIV-5. The overall seropositivity rates for CDV, CAV-2, CPV, and CPIV-5 were 83.8%, 77.8%, 99.3%, and 82.0%, respectively. The protection rate against CPV was the highest (98.3%) and that against CAV-2 was the lowest (44.8%) in dog sera. Male and female dogs showed no significant differences in seropositivity rates. CDV and CPIV-5 seropositivity increased with age in dogs, and the highest incidence and seropositivity rates of CPV indicated that Korean dogs have been continuously exposed to wild CPV, and that CPV is a pathogen that urgently requires attention among canine viral diseases.
Ebstein anomaly, right-to-left atrial septal defect, and cor triatriatum dexter in a cat: a case report
Authors: Park Soolyi , Oh Wonseok , Lee Daye , Lee Seunggon
Published: March 2024

A 6-month-old male Ragdoll cat presented with exercise intolerance. On physical examination, there was a grade 2/6 systolic murmur at the right apex. Diagnostic tests, including SpO2 measurement, blood tests, radiography, echocardiography, contrast echocardiography, and electrocardiography, were performed. Severe right atrial dilation, tricuspid valve leaflets and orifice displacement, right ventricular atrialization, septal leaflet adherence, anterior leaflet tethering, and right atrioventricular junction dilation were noted on echocardiography, alongside a right-to-left atrial septal defect. Cor triatriatum dexter and left ventricular aneurysm were observed. We diagnosed this case as having Ebstein anomaly with rare congenital heart deformities; which is rare in cats.
The Role of Serum IL-23 and Volatile Organic Compound Levels to RECIST 1.1 in The Evaluation of Therapeutic Response in Lung Cancer
Authors: Tjahyadi Rizal Muldani , Setyawan Ungky Agus , Astuti Tri Wahju , Djajalaksana Susanthy , Wardoyo Arinto Yudi Ponco
Published: March 2024

The Response Evaluation Criteria in Solid Tumors (RECIST 1.1) is the gold standard for the assessment of lung cancer progression. However, the assessment and diagnosis of early treatment failure is challenging due to the limitations of current tools, as well as the long intervals and unavoidable side effects.This study aims to correlate volatile organic compound (VOC) patterns, serum level of interleukin-23 (IL-23), and RECIST 1.1 to assess chemotherapy response in lung cancer patients at Saiful Anwar Hospital. A prospective observational study was performed to 47 lung cancer patients who received three cycles of platinum-based chemotherapy. Using the Breath Analyzer to measure certain volatile organic compounds (VOCs), the study observed that three of the seven VOCs examined, formaldehyde (CH2O), toluene (C7H8), and hexane (C6H14), showed lower levels after three cycles of chemotherapy. Furthermore, there was a negative correlation between RECIST1.1 and acetone (C3H6O) (p=0.023), while RECIST1.1 and methane (CH4) had a positive correlation (p=0.011). Moreover, a significant positive correlation was observed between IL-23 after-chemotherapy and RECIST 1.1 (p=0.000). According to this study, a correlation exists between methane, IL-23, and RECIST 1.1 after three cycles of chemotherapy. The increase in methane and IL-23 aligns with the disease progression determined by RECIST 1.1. Furthermore, The decrease in acetone after chemotherapy showed a negative correlation with RECIST1.1, consistent with disease progression.Keywords: Volatile Organic Compound, Interleukin-23, RECIST 1.1.
Impact of Donor Age on Human Platelet Lysate Quality and its Consequential Effects on HeLa Cell Growth in the Presence of Anti-Cancer Compounds
Authors: Mentari Diani , Wijayanti Gratiana Ekaningsih , Suhesti Tuti Sri , Muhammad Katon , Ritchie Ni Ken , Nurpratami Diah
Published: March 2024

An integral aspect of anticancer experimentation involves delineating the optimal dosage of the test compound to ascertain its efficacy in targeting malignant cells. Numerous variables may influence a compound's cytotoxicity, among which is the choice of cell culture medium. Within in vitro settings, supplementary mediums are employed to foster cellular proliferation. Platelet lysate (PL) serves as a growth supplement, presenting an alternative to fetal bovine serum (FBS), primarily due to its incorporation of growth factors such as platelet-derived growth factor (PDGF), a component absents in FBS. The integrity of PL may be subject to various factors, including the age of the donor. This study sought to evaluate the impact of donor age on PL quality. Furthermore, it aimed to discern whether PL derived from platelet concentrate (PC) blood components of different age cohorts influences the IC50 value in anticancer compound assessment. Expired PCs were utilized, subsequently classified into age categories: ≤30 years, >30 years, and a combination of ages. PL analysis encompassed parameters such as pH, blood profile, protein, glucose, and cholesterol levels. The investigation scrutinized the influence of PL quality, as a cellular growth supplement, on the anticancer compound cisplatin's activity against HeLa cells. Findings indicate that donor age influenced the IC50 value of cisplatin on HeLa cells. Notably, elevated cholesterol levels and decreased pH in PL from donor ages >30 years were associated with reduced cisplatin toxicity.Keywords: Cisplatin, Donor Age, HeLa, IC50, Platelet Lysate.
Implementation of the Provisions of the Cluster Theory into the Accounting System: Genesis and Evolution
Authors: VYSOCHAN Oleh , STANASIUK Natalia , HONCHAR Svitlana , HYK Vasyl , VYSOCHAN Olha
Published: March 2024

In current economic conditions, a large number of enterprises carry out their activities by joining into network (cluster) structures, which is one of the means of improving competitive relations in the external environment. To ensure the integration of the interests of participants in network structures by increasing the coordination and controllability of interactions, a significant place is given to the accounting system as the main source of information. The article aims to study the theoretical and methodological foundations of implementing the cluster economy concept in the accounting system. The methodological basis is the fundamental provisions of modern economic institutional theory and scientific works of scientists. As a result of the research, it was possible to analyze the historical aspects of the development of accounting support for managing cluster structures. The areas of development of accounting based on the provisions of economic theory and taking into account the specific features of cluster structures are identified and substantiated.
The Role of Emotional Intelligence in Making Successful Financial Decisions
Authors: BYKOVA Svitlana , ZHYLIN Mykhailo , BULAVINA Olena , ARTEMCHUK Mykyta , PURHANI Safar Hasan
Published: March 2024

Emotional intelligence (EI) as the ability for self-analysis, self-motivation, and self-regulation is necessary in the process of financial activity. It ensures informed decision-making, considering consequences and perspectives. The aim is to identify the influence of emotional intelligence on the effectiveness of decision-making by financiers. The following tests were used: EQ (Emotional/Empathy Quotient) test, Melbourne Decision Making Questionnaire, the Rathus Assertiveness Schedule, the Schubert Risk Propensity Test. Statistical processing of the results included the use of descriptive analysis, ANOVA, and regression analysis. The study found that financial workers with a high level of emotional intelligence have a pronounced “vigilance” decision-making style (F=113.4, p≤0.01), high assertiveness (F=103.3, p≤0.01), and risk propensity (F=137.3, p≤0.01). It was proved that emotional intelligence explains the “vigilance” decision-making style (β=0.943, R²=0.572), risk propensity (β=0.896, R²=0.424) and explains 48% of assertiveness (β=0.945, R²=0.483). It was confirmed that emotional intelligence is a predictor of successful financial decisions, it determines high assertiveness, vigilance, and risk propensity. Such results are useful for the development of training and retraining programmes for financiers. At the same time, including the development of assertiveness and risk propensity in professional and corporate training in parallel with the development of EI will give greater chances for the success of financial decisions. The obtained results are important for the financial and economic sphere, as they prove the effectiveness of EI in decision-making. This contributes to the improvement of the system of training competitive financiers and allows to expand aspects of the study of financial success.
Ethnobotanical study of medicinal plants used by iraqi herbalists in the management of Nephrolithiasis: A cross-Sectional survey conducted in Southern Iraq “Karbala.”
Authors: Humadi Suhad
Published: March 2024

Nephrolithiasis is one of the most significant urinary tract diseases, with an enormous socio-economic impact. Numerous research studies have been conducted to assess the potential of herbal medicine in managing kidney stones; however, further study is required in Iraq. The objective was to document the ethno-botanical uses of medicinal plants in managing nephrolithiasis in southern Iraq and analyse the herbalists’ diagnostic method. A cross-sectional survey was performed through face-to-face interviews with 48 herbalists practicing in Karbala. The results indicated the use of 19 species from 10 botanical families. Zea mays, Trigonella foenum-graecum and Tribulus terrestris exhibited the highest frequency of mentions, accounting for 81.25%, 56.25%, and 52.0%, respectively. The botanical plant families Apiaceae and Fabaceae were predominantly utilized, accounting for usage rates of 31.5% and 15.7%, respectively. Furthermore, the data indicated that seeds were the most utilized plant parts, and decoction was the predominant preparation technique. Moreover, the data showed that although a significant proportion of herbalists possessed a high level of education, most of these herbalists (72.9%) relied on patient symptoms rather than physician diagnosis when identifying nephrolithiasis, irrespective of their experience or education level. Herbalists commonly suggest cures for nephrolithiasis without considering the specific type and location of the stone. This study concluded that medicinal plants are significant for future research endeavors to treat and manage nephrolithiasis.
Effects of a CrossFit Training Program on Body Composition and Hematological Parameters in Young Soccer Players
Authors: Alsharab Omar , Triki Raoua , Jebabli Nidhal , Khalfoun Jihen , Zouhal Hassane , Ben Abderrahman Abderraouf
Published: March 2024

The study aimed to identify the effects of CrossFit training on body composition and hematological parameters in young soccer players. Forty soccer players voluntarily took part in this study, they were divided randomly into two equal groups: Experimental group (N=20) underwent a 12 weeks of CrossFit training program, and the control group (N=20) underwent 12 weeks of traditional training. Body composition and hematological parameters were measured before and after the experiment among both groups. As results, a significant time x group interaction effect was observed for body mass index (p=0.99; ES=0.45), body fat percentage (p=0.19; ES=0.36), and muscle mass (p=0.16; ES=0.57), which indicate a positively significant change of body mass index and body fat percentage, muscle mass (p<0.05). While a significant group x time effect was reported for body fat mass (p=0.04, ES=0.43) and basal metabolic rate (p=0.005, ES=0.55), with favor for experimental group compared to control group. Additionally results showed a statistically significant group x time effect for Hemoglobin (p=0.001; ES=0.24) Red blood cells (p=0.04, ES=0.56) and Hematocrit (p=0.007; ES=0.36) with favor for EG in comparison with CG group, an increasing was presents for all previous parameters respectively among experimental group (p<0.001). However, no statistically significant effect of group x time was indicated for platelets (p=0.16; ES=0.58), significant increasing was reported for both groups. CrossFit exercise program can be recommended as an effective program in enhancing and adjusting the vital indicators of young soccer players and improve performance.
Three Close-Readings and Psychoanalysis on the Doctor in “The Use of Force” by William Carlos Williams
Authors: Zhang Megan
Published: March 2024

In this paper, I intend to present three primary interpretations of The Use of Force, a short story written by William Carlos Williams. Two of the three readings are explored in pre-existing analytical works of literature, and the third is my own reading to determine the resolve of the moral dilemma in the story. Throughout the paper, I will argue that autonomy is justified to be overridden at times, however it is still unjust. Structurally, the paper is organized in a way starting with definitions to establish a foundation that will aid in understanding the interpretations. Such definitions include concepts within the Hippocratic Oath and other terms related to society that still reign true with the concepts explored in The Use of Force. The understanding of such issues is vital to establishing a perspective towards the story, and brings out more space for discussions. Then, I will discuss and analyze the short story including analysis of the doctor’s behaviour, in-depth quote analysis, thought experiments, and finally interpretations relating to the real world.
The relationship between parental involvement and children’s language acquisition
Authors: Funk Alexander
Published: March 2024

This study proposes that when parents are involved in providing learning support, the success rates for language acquisition are significantly higher. This paper explores the pedagogical strategies employed by non-Mandarin speaking parents through interactions to support their children’s language development. A cross case analysis carried out with five high achieving children and their families showed that parents were involved personally in their child’s education. They took it upon themselves to read with the child, play with the child, learn the language together with the child, assess the child and create opportunities for the child to practise the language. The study revealed that the support and psychological tools parents used helped to mediate their children’s language development process within family practices. These psychological tools could be adopted in classroom settings to supplement language acquisition pedagogies used by teachers.
Estimation of a decreasing mean residual life based on ranked set sampling with an application to survival analysis
Authors: Zamanzade Elham , Zamanzade Ehsan , Parvardeh Afshin
Published: March 2024

The mean residual lifetime (MRL) of a unit in a population at a given time t, is the average remaining lifetime among those population units still alive at the time t. In some applications, it is reasonable to assume that MRL function is a decreasing function over time. Thus, one natural way to improve the estimation of MRL function is to use this assumption in estimation process. In this paper, we develop an MRL estimator in ranked set sampling (RSS) which, enjoys the monotonicity property. We prove that it is a strongly uniformly consistent estimator of true MRL function. We also show that the asymptotic distribution of the introduced estimator is the same as the empirical one, and therefore the novel estimator is obtained “free of charge”, at least in an asymptotic sense. We then compare the proposed estimator with its competitors in RSS and simple random sampling (SRS) using Monte Carlo simulation. Our simulation results confirm the superiority of the proposed procedure for finite sample sizes. Finally, a real dataset from the Surveillance, Epidemiology and End Results (SEER) program of the US National Cancer Institute (NCI) is used to show that the introduced technique can provide more accurate estimates for the average remaining lifetime of patients with breast cancer.