bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-target mechanism of polyherbal extract to treat diabetic foot ulcer based on network pharmacology and molecular docking
Authors: Murdiana Happy Elda , Murwanti Retno , Fakhrudin Nanang , Ikawati Zullies
Published: April 2024

Introduction: Diabetic foot ulcer (DFU) potentially leads to loss of function, infections, hospitalization, lower-extremity amputation, and even death. The potential therapeutic efficacy of a polyherbal candidate named TIP-Heal was identified for treating DFU. TIP-Heal, which stands for Tinospora crispa, Isotoma longiflora, and Piper betle L var nigra, consists of extracts from these three herbs in a ratio of 2:1:1. The Indonesian population commonly uses these herbs due to their wound-healing properties. It is our interest to analyse the mechanism of the polyherbal extract using network pharmacology and molecular docking. Methods: This study uses network pharmacology and molecular docking methods to analyze the multi-target mechanism of active compounds in TIP-Heal extract for DFU treatment. The proteins targeted by the bioactive chemical present in TIP-Heal and DFU were identified within a particular dataset with the keyword "homo sapiens." The identified target proteins were assessed using gene ontology (GO) analysis, the Kyoto Encyclopaedia of Gene and Genomes (KEGG) pathways, protein-protein interactions (PPIs), and molecular docking. Results: The critical proteins obtained were AKT serine/threonine kinase 1 (AKT1), caspase-3 (CASP3), epidermal growth factor receptor (EGFR), proto-oncogene tyrosine-protein kinase Src (SRC) and matrix metalloproteinase-9 (MMP-9). Several compounds, namely PubChem (Compound Identifier=CID: 5319898), 3-epiursolic acid, palmitic acid, and alpha-linolenic acid showed great potential as viable candidates to facilitate the healing process of DFU. Conclusion: The findings of this study indicate that the TIP-Heal extract has the potential to be used as a natural herbal treatment for DFUs with the involvement of AKT1, CASP3, EFGR, and SRC proteins.
Solanum trilobatum leaf extract-derived silver nanoparticles downregulate the PI3K/AKT/mTOR signaling pathway and attenuate oral squamous cell carcinoma cell proliferation
Authors: Ganesan Anuradha , Kumar N Gautham , Natarajan Prabhu Manickam
Published: April 2024

Introduction: Oral cancer’s aggressive nature poses a significant health risk, demanding timely diagnosis and effective treatment. Despite progress in conventional therapies like chemotherapy and surgery, their limitations drive the exploration of alternative strategies. This study assessed Solanum trilobatum-derived silver nanoparticles (AgNPs) in impacting cancer cell cycles, inducing apoptosis, and modulating key pathways, including the phosphoinositide 3-kinase (PI3K)/Protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway, leveraging phytotherapy and nanotechnology—a promising frontier in cancer treatment. Methods: AgNPs were synthesized through the reduction of ions and stabilized using aqueous leaf extracts of S. trilobatum. After the characterization of AgNPs, the mRNA Gene Expression and mitochondrial membrane potentials (MMPs) were assessed. DNA fragmentation was done and DNA pattern by gel documentation system was observed. The study also assessed the modulation of the PI3K/Akt/mTOR cascade, impacting tumor growth and proliferation. Results: Biosynthesized AgNPs were characterized using UV-visible spectrophotometry (UVvis), energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and Fourier-transform infrared (FTIR) spectroscopy. DNA fragmentation exhibited a typical ladder pattern. Dose-dependent changes in MMP were observed in the treated oral cancer cells. The effect of S. trilobatum-derived AgNPs in targeting the cell signaling pathway correlated significantly with their anticancer potency (P<0.001). Conclusion: This study reveals S. trilobatum leaf extract-based AgNPs as a natural cytostatic agent against oral squamous carcinoma. Utilizing nature’s resources and nanoscale science, they hold promise for enhancing oral cancer treatment outcomes and survival rates.
Integrative computational approaches for designing novel alpha-glucosidase inhibitors based on curculigoside A derivatives: Virtual screening, molecular docking, and molecular dynamics
Authors: Asnawi Aiyi , Mieldianisa Shifa , Aligita Widhya , Yuliantini Anne , Febrina Ellin
Published: April 2024

Introduction: Over 422 million people worldwide suffer from diabetes, causing 1.5 million fatalities annually. The existing medications have shortcomings, including poor glucose control and adverse effects. The present study aimed to create possible alpha-glucosidase inhibitors utilizing a curculigoside A derivative ligand-based model. Methods: A pharmacophore model was constructed utilizing the structure information of curculigoside A derivatives and PharmaGist. Subsequently, virtual screening, molecular docking, and molecular dynamics were employed to simulate the hits. Results: From six training sets, eleven pharmacophore models were developed; the model with the highest score (18.0435) was chosen for further analysis. Using the verified pharmacophore model, 270 547 chemicals from the ZINC natural product database were subjected to virtual screening. Subsequently, molecular docking was performed on the top 1000 hits with AutoDock Wizard from PyRx. This analysis unveiled 434 hits with better binding energies than acarbose, the native ligand. Subsequently, second optimal docking configurations were evaluated with AutoDock 2.4; this process yielded the discovery of three prospective inhibitors (ZINC000150350051, ZINC000008382292, and ZINC000085595291) characterized by the most advantageous binding energies. To evaluate the stability and dynamics of these ligand-receptor complexes, Gromacs 2022 molecular dynamics simulations were executed for one hundred nanoseconds. Out of the three hits, ZINC000085595291 (Hit03) exhibited good energy components and interaction stability constantly during the simulation. Conclusion: The integrated computational strategy identified promising alpha-glucosidase inhibitors in curculigoside A compounds, highlighting the potential of ZINC000085595291 (Hit03) as a potential diabetes therapeutic agent.
Phytochemistry and antimicrobial activity of Moroccan Origanum compactum and Ruta montana essential oils against nosocomial bacteria
Authors: Flouchi Rachid , Chraibi Marwa , Elmniai Abderrahim , Fahsi Karim , Touzani Ibrahim , Farah Abdellah , Fikri-Benbrahim Kawtar
Published: April 2024

Introduction: Healthcare-associated infections are a global public health issue with farreaching individual and economic repercussions. The microorganism’s multi-resistance frequently increases the risk that can be lowered by using biomolecules of medicinal plant essential oils (EOs). This study investigated the phytochemical components and antimicrobial potential of the EOs of Moroccan Origanum compactum and Ruta montana gathered from Taza Region. Methods: The EOs’ chemical analysis was performed by GC/MS and their antimicrobial effects were assessed by the microplate dilution method against eight nosocomial resistantbacterial strains. Results: The main constituents of O. compactum EO were Thymol (29.56%), carvacrol (26.44%), γ-terpinene (18.86%) and p-cymene (12.01%), while those of R. montana EO were 2-undecanone (85.76%), 2-nonanone (3.95%), 2-decanone (3.67%) and 2-dodecanone (1.94%). The O. compactum EO had important antimicrobial effects on all bacteria experienced. The lower minimum inhibitory concentration (MIC) values were obtained for the tested Staphylococcus species (0.062%, 0.125% (v/v)) while the highest one (2% (v/v)) was obtained for Klebsiella pneumonia and Pantoea spp. The R. montana EO showed MIC values of 4% (v/v) for Pantoea spp. and 8% (v/v) for the other tested strains except K. pneumonia for which no effect was shown. Conclusion: Therefore, these EOs, especially the O. compactum one, have an interesting antibacterial potential against nosocomial infections and might be used to develop new antimicrobial agents.
The Experience of Nursing Professors and Students about the Objective Structured Clinical Examination
Authors: Nematzad Pouya , Pourghane Parand , Besharati Fereshteh , Mozafari Seyed Mohammad Sadegh
Published: April 2024

Background: Clinical evaluation in medical sciences is one of the important components of education. One of these evaluations is the clinical assessment for final-year nursing students when they are going to graduate and start their profession. To this end, this study aimed to explore the experiences of nursing professors and students regarding the Objective Structured Clinical Examination (OSCE). Methods: This qualitative study was conducted using a content analysis approach on 7 nursing professors and 21 nursing students who completed OSCE in 2019 at the Nursing and Midwifery School of Guilan University of Medical Sciences in northern Iran. The participants were selected using purposive sampling and the data were collected through semi-structured individual interviews. The collected data were analyzed using the content analysis approach proposed by Graneheim and Lundman. The credibility of the findings was checked using the criteria proposed by Guba and Lincoln. Results: The data analysis revealed 3 main categories and 10 subcategories: OSCE as a highly efficient test(the requirement for reviewing the courses, student benchmarking, and randomly arranged questions), OSCE challenges (the low assessment ability of the test, the influence of the nursing instructor’s prior knowledge, and having little practical experience), the solutions to improve OSCE (diversification of evaluation techniques, shortening the distance between theory and practice, the effectiveness of the OSCE scores for graduation, and the application of stress reduction methods). Conclusion: Despite some problems such as its stressful nature and its unknown format for students, OSCE seems to be effective for the clinical assessment of students before their graduation. Taking advantage of the professors’ and students’ perspectives can eliminate or reduce the problems and improve the positive points for planning and conducting the OSCE in the future.
Iranian Obese Women’s Lived Experiences of Social and Linguistic Factors Shaping Emotional Eating Behavior: A Phenomenological Study
Authors: Ebrahimi Ehteram , Mohammadi Shirmahaleh Fatemeh , Mardani Hamooleh Marjan , Habibi Asgarabad Mojtaba
Published: April 2024

Background: Emotional eating is harmful to health and is highly prevalent in obese women. Hence, an awareness of factors underlying emotional eating is important for weight management and maintaining women’s health. Research evidence indicates that several factors contribute to emotional eating behavior. The present study aimed to explore obese young Iranian women’s lived experiences of social and linguistic factors shaping emotional eating behavior. Methods: This qualitative and hermeneutic phenomenological study was conducted on 17 young women living in Kermanshah or Karaj, Iran who experienced emotional eating and had a body mass index (BMI) of 30 and higher. The participants were selected using purposive sampling with maximum variation in terms of demographic characteristics. The data were collected through in-depth individual and face-to-face interviews and analyzed using Dickelman et al’s seven-step phenomenological approach. Results: The data analysis revealed that social and linguistic factors underlying emotional eating behavior can be explained by two themes including social influence and linguistic culture. Social influence further accounted for compensating for the stigma of thinness, relieving the stigma of obesity, group conformity, and following taboos to cope with sexual and emotional desires. In addition, linguistic culture was explained by two subthemes including associating grieving with eating and the metaphor of swallowing anger. Conclusion: Following the findings of the study, psychotherapy interventions can be planned to address emotional eating and weight management with a focus on the role of social influence and the effects of spoken language in the development of emotional eating behavior.
Developing a Grounded Theory Model of Effective Factors and Consequences of Gender-Affirming for Transgender People and Those with Undifferentiated Gender in Iran
Authors: Omidian Morteza , Sajadian Hossein
Published: April 2024

Background: Transgender people and those who have an undifferentiated gender identity face various personal and social challenges due to their dissatisfaction with the gender role and the desire to behave differently from the gender role. Thus, focusing on this group of people is one of the issues in health and psychology. To this end, the present study aimed to explore more deeply the challenges and problems faced by this group of people. Methods: This qualitative study was conducted based on the grounded theory proposed by Corbin and Strauss on 15 members of social networks and the Association of People with Gender Dissatisfaction. The participants were selected through purposive sampling from among those with undifferentiated gender identities from childhood to adulthood. The data were collected via individual in-depth interviews with the participants. The collected data were analyzed using the systematic grounded theory approach to extract related categories and codes and develop a conceptual model. Results: The analysis of the data revealed 54 themes that were grouped into 9 subcategories and 5 main categories. Gender affirming was extracted as the core phenomenon. The causal factors included the feeling of living in another person’s body and problems in social relationships. Contextual factors were divided into 4 subcategories including family challenges, positive and negative public reactions, peer relationship problems, and economic challenges. The intervening factors were school problems and the role of media. In addition, the consequences were the positive and negative experiences of life in another body. Finally, the extracted strategies were support and individual coping strategies. Conclusion: Social factors and family and school play an important role in aggravating the problems of people with gender dissatisfaction. Focusing on empowering these people can help them adopt effective coping strategies. Besides, given the lack of recognition for people with gender dissatisfaction, raising public awareness of the challenges faced by these people is particularly important.
Iranian Nurses’ Behavioral Changes during the COVID-19 Pandemic: A Qualitative Study
Authors: Sarani Arezoo , Seyed Askari Seyed Mostafa , Beigzadeh Amin , Mohammadkhani Minoo , Tavakolisani Mohammadsadegh , Khanjani Narges
Published: April 2024

Background: The large-scale spread of COVID-19 affected communities with many deaths worldwide causing significant concerns. Due to being on the front line of fighting against this disease, a great number of healthcare providers lost their lives. Accordingly, this study aimed to explore the changes in nurses’ behavior and practice while taking care of COVID-19 patients. Methods: The present study was conducted using a qualitative conventional content analysis approach in 2020-2021. The participants were 14 nurses taking care of COVID-19 patients in the infectious diseases wards of a teaching hospital affiliated with Kerman University of Medical Sciences. The data were collected through interviews with the nurses, and data collection continued until data saturation. The collected data were analyzed based on the steps proposed by Graneheim and Lundman. After recording and transcribing the interviews, the participants’ statements were categorized into semantic units. Data analysis was performed using MAXQDA-10 software. Results: The majority of nurses reported significant behavioral changes that were categorized into five main themes including intensification of protective measures and increase in concentration, emergence of mental and psychological symptoms, increase in the sense of responsibility towards the family, recourse to prayer and religious rituals, and increased empathy with patients. Conclusion: According to the research findings providing material and spiritual incentives as well as support to personnel to increase their motivation and work productivity should be taken into consideration by officials during epidemics. Moreover, actions such as providing free psychological counseling are suggested to calm the personnel.
Experiences of Surgical Technology Students of Their First Appearance in the Operating Room
Authors: Dehghan Abnavi Samaneh , Aliakbari Fatemeh , Ebrahimi Shaikhshabani Leila
Published: April 2024

Background: Clinical education is a critical stage of education and plays a major role in shaping students’ professional competencies. The clinical learning environment has a complex nature and has a significant impact on students, especially newly admitted ones. Thus, the initial experience in clinical settings will significantly affect the student’s performance. To this end, this study sought to explore the experiences of surgical technology students of their first appearance in the operating room. Methods: This qualitative study was conducted using a descriptive phenomenological approach. The participants were 15 secondand third-semester students of surgical technology who entered the study through purposive sampling. The data were collected through individual interviews. Data analysis was performed simultaneously with data collection through Colaizzi’s seven-step content analysis method. Results: A total of 101 primary codes were extracted from the collected data. The extracted codes were grouped into 7 subcategories. After removing duplicate codes, 3 main themes were revealed from the participants’ experiences (conflicting perceptions in the learning environment, preparedness before attending the operating room, and feelings and emotions). Conclusion: The students’ experiences of their first appearance in the operating room indicated that their expectations changed compared to what they imagined. The stressful nature of surgical technology and the students’ experiences when starting the internship highlight the need for some necessary measures to prepare students before entering the hospital and to improve the quality of clinical education for these students.
A Qualitative Study of Barriers, Facilitators, and Challenges of Providing High-Quality Hypertension Care in Health Centers in Iran: Perspectives of Healthcare Care Workers, Patients, and Health Center Managers
Authors: Ghorbanzadeh Sepideh , Khodayari-Zarnag Rahim , Babaie Javad
Published: April 2024

Background: Although the vital role of early diagnosing, and properly controlling hypertension has been emphasized for decades, a large number of hypertension patients still encounter barriers and challenges in accessing qualified cares. This study examined and identified barriers, facilitators, and challenges of providing high-quality care for patients with hypertension in health centers in Tabriz, Iran. Methods: A descriptive qualitative study was conducted based on purposive sampling. The participants in this study included health care workers at health centers, patients with hypertension, and health centers managers at official positions (n=19). Data was gathered through semi-structured interviews. Collected data was analyzed thematically. Results: The mean duration of the interviews was 40 minutes (range: 30 to 60 minutes). The barriers were categorized into areas (sub-themes) of patient-related and health-center barriers. Facilitators included patient-related factors, external and environmental activities of health centers, and activities of Iranian health system. Furthermore, the challenges were categorized into (sub-themes) patient-related, environmental, and health system challenges. Conclusion: There are major barriers and challenges in providing qualified and comprehensive services for patients with hypertension. Stakeholders should consider removing these barriers and challenges, and facilitators should be used to provide health services to hypertension patients.
Pediatric Nurses’ Perceptions of Missed Care: A Qualitative Study
Authors: Dadgari Atena , Bagheri Imane , Salmani Naiire , Barati Mojgan
Published: April 2024

Background: Pediatric nurses are responsible for caring for children and their families; thus, investigating missed care in the pediatric ward is important and helps to improve the quality of care. Accordingly, this study aimed to explain the perceptions of pediatric nurses about missed care. Methods: This study was conducted using content analysis on 15 pediatric nurses selected by purposive sampling. The data were collected through in-depth semi-structured interviews. After obtaining informed consent, interviews were audio-recorded and transcribed verbatim. MAXQDA software (version 10) was used to facilitate coding and thematic analysis. Results: Four main categories emerged from the data analysis, including missed family-centered care, unsafe care, predisposing factors, and adverse outcomes. Conclusion: The findings showed that from the perspective of pediatric nurses, missed care occurs in different dimensions, including psychological support, communication, education, assessment, drug treatment, and infection control, and it can ultimately lead to mother’s dissatisfaction and bring about adverse effects on the child’s recovery besides harming the nurse.
Packing Soft Polygons in a Minimum Height Rectangular Target Domain
Authors: Melashenko Oksana , Romanova Tetyana , Pankratov Oleksandr , Shekhovtsov Sergiy , Martinez-Gomez Carlos
Published: April 2024

The paper studies packing polygons of variable shapes, regarding the stretching coefficient, in a rectangular target domain of minimum height. Packing objects of a variable shape have a wide spectrum of applications, e.g, in biology, materials science, mechanics, land allocation, and logistics. Interest in these problems is also due to the modeling of the structures of porous media under pressure, e.g., for creating test models of artificial digital cores. Elements of porous media can be deformed under the influence of an external force, but the mass of each particle remains unchanged. This corresponds to conservation of area for the two-dimensional case. Polygonal objects must be completely contained within the target domain (containment constraint) and do not overlap (non-overlapping constraint), provided they have free translations, continuous rotations, stretch transformations, and conserve their area. The phi-function technique is used for an analytical description of the placement constraints for variable shape polygons. Quasi-phi-functions for describing non-overlapping constraints and phi-functions for describing containment constraints are defined. The packing problem is presented in the form of a nonlinear programming model. A solution strategy is proposed, which consists of the following stages: generation of feasible starting points; search for local minima of the problem of packing soft polygons for each starting point using the decomposition algorithm; choosing the best local minimum found at the previous stage. To search for smart starting arrangements, an optimization algorithm for packing original polygons using their homothetic transformations is applied. Decomposition of the problem of packing polygons of variable shapes is based on an iterative procedure that allows reducing a large-scale problem to a sequence of smaller nonlinear programming problems (linear to the number of objects). Numerical examples are provided for oriented rectangles and non-oriented regular polygons. Keywords: packing, polygons, stretch transformation, rectangular container, quasi-phi-functions, optimization, decomposition algorithm.
Automated Schedule System for Universities under the Bologna Education Process
Authors: Aida-Zade Kamil , Ismibayli Reshad , Rzayeva Sona
Published: April 2024

Introduction. Countries that have joined the Bologna Process in higher education assume certain obligations. One of them is the transition to a credit education system, which is based on the personal participation of each student in the formation of their curriculum. Each student has the opportunity to structure the learning process, choose subjects and the sequence of their study within the framework of the curriculum for the chosen specialty, create their own individual schedule in accordance with their interests, capabilities and needs. The credit training system is asynchronous. Naturally, software applications for scheduling classes, developed for the classical education system, do not work in this case.
Purpose. Development of an algorithm and software for a class scheduling system designed for the credit education system and taking into account its features, and also meets all the “hard” restrictions and most of the “soft” requirements for the class schedule.
Results. The algorithm and software of the interactive system of scheduling classes for universities that have joined the Bologna process, which takes into account the features of credit-modular system of training, have been developed.
Conclusions.
The developed system covers the full cycle of including students in groups to study selected subjects and teachers, starting from scheduling teachers, registering students and ending with the formation of individual schedules for each student;
The proposed iterative process of scheduling makes it possible to make changes to the schedule of teachers and re-register students in the case of teachers who have not formed groups, or a significant number of students who were unable to enroll in subjects of interest to them;
The interactive mode of operation with the system combines an automated process of scheduling with active participation of the user responsible for scheduling;
The system guarantees the preparation of permissible timetables for teachers and students, taking into account the implementation of all "hard" restrictions, and significantly reduces the time required for scheduling;
The system ensures to the maximum extent the quality of teachers’ schedules, namely, taking into account “soft” requirements with the active participation of the user, who has the opportunity to choose an option that reduces the value of the function proposed in the article that evaluates the quality of the schedule;
The developed system ensures the effective use of the classroom fund in accordance with its capacity, specialization and affiliation. Keywords: Bologna process of education, credit system, asynchronous learning system, class schedule, scheduling requirements, computer system.
The Role of the Supercomputer in the Modern World of Innovative Technologies
Authors: Kravchenko Nataliia , Golovynskyi Andriі , Grabowski Andriі , Malenko Andriі
Published: April 2024

What is a supercomputer and why is it needed? What place does it occupy among computing equipment? Thanks to this article, we will determine the evolution and role of the supercomputer in the modern world and in the life of an average citizen.
A supercomputer is a class of the most powerful computer systems available, which are evaluated in comparison with currently existing general purpose computer systems and the level of technology development. In general, the term "supercomputer" refers to a complex of server computers. All of them are connected to each other and work in parallel through a high-speed network.
The similarity of a home computer and a supercomputer lies in their functions – data storage and processing, belonging to the same von Neumann architecture (the architecture of computing machines, the feature of which is the joint storage of data and machine commands in cells of the same memory). But the difference is huge in quantitative characteristics: these are the arrays of data that can be processed on these devices and the speed of performing the assigned tasks. By the way, a new unit of measurement – FLOPS – was proposed for measuring the speed of supercomputers. It is thanks to this value that performance is measured - the higher the number, the more powerful the computer is and which serves as the basis for ranking supercomputers.
Today, supercomputers help solve a number of tasks in various fields – medicine, physics, mathematics, energy, etc. and are considered advanced computing technology. Traditionally, supercomputers are not considered rare: their development is ongoing and they bring a lot of benefits in many areas. In the future, powerful computing machines can become the main assistants in fields closely related to machine learning and artificial intelligence. Keywords: supercomputer, development evolution, computer architecture, FLOPS.
ФОРМИРОВАНИЕ ПРОФЕССИОНАЛЬНОЙ ЛИЧНОСТИ ПЕРЕВОДЧИКА В СВЕТЕ КОНЦЕПЦИИ ПЕДАГОГИКИ ПЕРЕВОДА
Authors:   Пермский национальный исследовательский политехнический университет, Аликина Е. В. , Кушнина Л.В.
Published: April 2024

The article's relevance is conditioned by the expansion of the methodological basis of translator training within the framework of an independent area of research - translation pedagogy. The research aims to substantiate the leading principles of translation pedagogy based on a combination of discursive, cognitive, semiotic, and pedagogical approaches. The methodological foundation of the research was the provisions of translation pedagogy, in particular, the methodological component of the concept, including three blocks of analysis: content-target, organizational-processual, and result-evaluation. The material for the analysis was the practice of teaching the discipline "Topical Problems of Translation" to master's students, in particular, the work on the research project "Portrait of the Russian Translator".
ЭКОЛОГИЧЕСКИЙ ДИСБАЛАНС КАК БАРЬЕР К СТАБИЛЬНОСТИ И УСТОЙЧИВОМУ РАЗВИТИЮ КАЗАХСТАНА
Authors:   Высшая школа социально-гуманитарных наук, Казахстан, Асанова Г.К. , Адильбектеги Г.А. ,   Евразийский национальный Университет им. Л.Н. Гумилева, Уалтаева А.С. , Сайн Э.Д. ,   Институт истории и этнологии им. Ч.Ч. Валиханова,   КазНУ им. аль-Фараби
Published: April 2024

Global challenges group the long-established traditional classification: environmental, domestic, geopolitical, social, technological. In our opinion, calls should play a decisive role in this list. Economic growth is one of the goals of sustainable development of countries, the balance of which is possible with three main components: economic growth, social responsibility and environmental balance. Kazakhstan faces significant barriers to economic stability and sustainable development. The article, based on the achievements of domestic science, the main provisions of strategic and program documents of the state, archival and statistical data, examines the socio-economic consequences of an environmental disaster as a barrier to economic stability and sustainable development of the country.
КӨРКӨМ КОТОРМОДОГУ ГЕНДЕРДИК ӨЗГӨЧӨЛҮКТҮН ЛЕКСИКАЛЫК ДЕҢГЭЭЛИН КЫРГЫЗ ЖАНА АНГЛИС ТИЛДЕРИНДЕ САЛЫШТЫРЫП ИЗИЛДӨӨ
Authors:   И.К.Ахунбаев атындагы КММА, Байболова А.
Published: April 2024

This article examines the theoretical issues of the gender aspect of linguistic research, in particular in translation practice. The issues of the influence of the gender identity of the authors on the style of writing and the nature of the work are considered. Dependence on social, sociocultural and political factors of carriers of a particular gene is also described. And against the background of historical need, the development of the feminist theory of translation. The main purpose of this scientific article is to identify the features of the feminist theory of translation at the lexical level and describe the gender characteristics that influence the choice of language means. Also, with the help of works of art, a comparative analysis of the place of use of figurative means, stylistic features of characters, objects, and the belonging of words to the male or female sex is carried out.
ПРЕДЛОЖЕНИЕ КАК ОБЪЕКТ СОПОСТАВИТЕЛЬНОГО ЯЗЫКОЗНАНИЯ
Authors:   БГУ им. К.Карасаева, Ибраимова Т.О. , Мамбетова К.Ш.
Published: April 2024

The article shows that the sentence is recognized as a fundamental unit of language in comparative linguistics. This structural-syntactic phenomenon exists in a static state in the language system. It is pointed out that an utterance, being a dynamic phenomenon realized in speech, is not a subject of study in comparative linguistics. The sentence, and with it the language's syntax, is recognized as the indispensable linguistic structure with which the comparative study of two or more unrelated languages should begin. The position that the sentence, modality, and proposition constitute the main element of natural language is taken into account. It is concluded that the sentence unit is regarded as the most significant object for comparative linguistics since it is a necessary component of a language system.
ОКУУЧУЛАРДЫН КЕП МАДАНИЯТЫН ӨСТҮРҮҮНҮН МЕТОДДОРУ
Authors:   И.Арабаев атындагы КМУ, Муратов А.Ж. , Исакова С.Т. ,   К.Тыныстанов атындагы ЫМУ
Published: April 2024

The article presents ideas about teaching methods, ideas, recommendations on the methodology for the development of written and oral speech of students in the Kyrgyz literature lesson. In our proposed school, exams on methods of adapting students to speech and writing activities were conducted in experimental classes. Using the example of Kyrgyz literature lessons in grades 5-8, the principles and means of applying the methods are described. Currently, there is a need to actively use our state language, especially office work, but there is reason to believe that some representatives of our nation do not speak the Kyrgyz language well, are able to make sentences and write competently. One of the reasons for illiteracy in the field of speech culture and writing is that a child from an early age in the family, kindergarten, school, secondary and higher educational institutions receives little influence on the rich language of folk tales, songs, dastans, including the national epic “Manas".
ПОЛИТИЧЕСКАЯ СОЦИАЛИЗАЦИЯ КАК ОСНОВА ГРАЖДАНСКОГО ОБЩЕСТВА В КЫРГЫЗСТАНЕ
Authors:   БГУ им. К. Карасаева, Канатбеков Э.К.
Published: April 2024

This article analyzes the process of political socialization in the context of civil society in Kyrgyzstan. The study examines various aspects of political socialization and identifies factors that influence the formation of political beliefs and activism of citizens, including education, mass media, and the role of political parties. The paper focuses on the significant role of education and the media in shaping political socialization and identifies the challenges facing contemporary civil society in Kyrgyzstan. The author suggests possible strategies to strengthen political activism and civic participation in the country to contribute to a better understanding of the relationship between political socialization and the formation of civil society. This study aims to identify potential strategy.
ONEGIN AND MANAS, VALIKHANOV AND BELINSKY; RUSSIAN LITERARY CRITICISM AND KYRGYZ ORAL POETRY
Authors:   American University of Central Asia, Plumtree J. K.
Published: April 2024

This paper examines the original context of the words ‘encyclopaedia’ and ‘epic’ concerning Manas. A New Historicism approach to the origin of this association, an 1861 Russian-language publication by Chokan Valikhanov, illuminates his likely use of a formulation - both verbal and conceptual - of literary critic Vissarion Belinsky, and placing Valikhanov’s interest in epics in pan-European (and Russian) early-nineteenth century socio-political context. Valikhanov’s comments display the placing of an interpretative framework from Russian literary criticism onto Kyrgyz oral poetry. This paper questions the continued use of the terminology related to nineteenth-century Russian colonialism and its significant impact on the Manas interpretation and valueing.
АЗЫРКЫ ЭТАПТА КЫРГЫЗ РЕСПУБЛИКАСЫНДА ИМПОРТТУН КЫСКАРЫШЫНА ИННОВАЦИЯЛЫК ЭКСПОРТТУН ӨСҮШҮНҮН НАТЫЙЖАЛУУЛУГУНУН ТААСИРИ
Authors:   Международная школа медицины МУК, Азимова Г. Р. , Турганбаева С.М. ,   БГУ имени К. Карасаева
Published: April 2024

This article emphasizes that the development of export and import opportunities using innovative technologies will help improve the competitiveness of products, as well as expand their presence in the global market. The article notes that over the past five years, the country's foreign trade turnover has remained stable, and the import of goods significantly exceeds the volume of exports, which can pose a threat to the economic security of the state. To solve this problem, it is proposed, first of all, to diversify sectors of the economy, introduce innovative technologies into production processes and actively expand export activities world market.
КРОСС-КУЛЬТУРНОЕ ПРЕПОДАВАНИЕ В МЕЖКУЛЬТУРНОМ ОБРАЗОВАНИИ ИНОСТРАННЫХ СТУДЕНТОВ
Authors:   БГУ им. К. Карасаева, Усенова Н.Э. , Ли Кунь ,   БГУ имени К. Карасаева
Published: April 2024

The study investigated foreign student teaching conditions through cross-cultural interactions with modern educators. Notably, the authors employed a two-fold framework of cross-cultural education: objective and subjective. Objective factors encompass external variables like curriculum structure, teaching mechanisms, academic environment, literacy, teacher attitudes, research skills, teaching style, and leadership level. The study also identified student motivation, attitude, ability, cultural differences, conflict resolution strategies, and cross-cultural communication skills as influential elements. Ultimately, the research concluded that incorporating a multicultural environment within international cooperation projects fosters greater cross-cultural exposure.
К ВОПРОСУ О МЕЖКУЛЬТУРНОЙ АДАПТАЦИИ ИНОСТРАННЫХ СТУДЕНТОВ, ПРИЕЗЖАЮЩИХ В КИТАЙ ПО ИНИЦИАТИВЕ «ОДИН ПОЯС, ОДИН ПУТЬ»
Authors:   Северо-Западный педагогический университет, Ланьчжоу, Ганьсу, КНР, Си Чэнь
Published: April 2024

In recent years, the number of foreign students from Belt and Road countries has increased further. The cultural adaptation problems caused by living in a foreign culture will have an impact on their psychology. Therefore, for international students in China, cross-cultural adaptation is the first challenge they have to face after studying and living in China. This article takes the intercultural adaptation of Chinese international students as a starting point, analyzes the dilemmas and problems they face, and proposes strategies to improve the intercultural adaptation ability of international students from the perspective of strengthening cultural contacts, promoting exchanges between Chinese and international students, and also increasing psychological adaptability.
АНГЛИС ТИЛИНДЕ ТҮРКИЗМДЕРДИН ПАЙДА БОЛУУ ТАРЫХЫ
Authors:   БГУ им. К. Карасаева, Кадыркулова Ф.Д. , Чурмукова Р.К.
Published: April 2024

Relations between peoples are impossible without the communication of languages. This article examines the issue of words adopted into the English language with the help of Turkic languages that are used in the modern language. The languages of the Turkic peoples have left many traces in different languages. Also, to review the nature of Turkisms in English, to reveal the nature of assimilation of Turkisms in two language cultures and the general features of the communication process, and to determine the features of the development of the semantics of its usage. In addition, the history of the emergence of Turkisms in the English language is intended to determine the features of its usage and semantics. In dealing with Turkisms, it should be noted that the English language is deep and wide. It is defined as the process of transition or entry of elements of one language into another language as a result of linguistic contacts.
Indicators for evaluating the quality of life of men injured by the consequences of combat actions
Authors: Vorobets D.Z. , Chaplyk V.V. , Besedina А.S. , Vorobets М.Z. , Onufrovych O.K. , Fafula R.V. , Vorobets Z.D.
Published: April 2024

The article presents the results of a comparative analysis of the responses of war victims to questions of the non-specific "ShortForm-36 Health Status Survey" (SF-36) questionnaire to determine the quality of physical and mental life at the time of filling out the questionnaire. The SF-36 questionnaire is one of the most common methods of measuring health-related quality of life and shows general well-being and the degree of satisfaction with aspects of a person's life that are affected by health. The vast majority of examined men injured as a result of hostilities were aged 30–49. It was found that against the background of a decrease in all indicators on the scales of the physical components of health, the most pronounced changes were recorded in the indicators of general health and role functioning caused by physical condition. In the psychological domain, the most pronounced changes were recorded in such components as mental health, vital activity and social functioning. A number of correlations were established between quality of life indicators in victims of hostilities. The closest probable positive correlation in men injured as a result of hostilities was established between physical functioning and role functioning caused by emotional state (r=+0.64; p<0.05). A positive correlation was also found between general health and physical functioning (r=+0.43; p<0.05), between general health and role functioning caused by emotional state (r=+0.34; p<0.05), a probable positive relationship between mental health and life activity (r=+0.34; p<0.05) and pain intensity (r=+0.42; p<0.05). The correlation between role functioning caused by emotional state and role functioning caused by physical state was negative and amounted to -0.37 (p<0.05).

Keywords: SF-36, physical health, mental health.
Bridging Artistic Traditions - Enriching Metalwork and Jewelry through Islamic Art Patterns and Etching Acid Technique
Authors: Alayar Moneerah , Alrashidi Najlah , Alrashidi Eiman
Published: April 2024

تتناول هذه الدراسة إمكانية دمج أنماط الفن الإسلامي في الأعمال المعدنية والمجوهرات المعاصرة باستخدام تقنية النقش الحمضي. وتؤكد على القيمة التاريخية والثقافية الدائمة لهذه الأنماط الفنية، المتجذرة بعمق في العقيدة والثقافة الإسلامية. وتجدر الإشارة إلى ان قيمة هذه الأنماط تمتد إلى ما هو أبعد من مجرد الجماليات، فهي بمثابة حافز لتكوين روابط روحية عميقة. تسلط مراجعة الأعمال الحالية الضوء على كيفية تأثير هذه الأنماط على الفن الحديث والهندسة المعمارية ومجالات التصميم المتنوعة، مما يعرض أهميتها المستمرة. بالإضافة إلى ذلك، تستكشف هذ الدراسة فوائد استخدام النقش الحمضي في صناعة المجوهرات، مع التركيز على الدقة والتعقيد والحفاظ على الرمزية الروحية والثقافية المرتبطة بالفن الإسلامي. تتوافق أهداف هذه الدراسة مع النتائج التي توصلت إليها من خلال التأكيد على أهمية السياق التاريخي، وإمكانيات التكامل، وتأثيرات أنماط الفن الإسلامي، وتأثيرها على تصاميم الأعمال المعدنية والمجوهرات المبتكرة. تضع هذه الورقة الأساس للدراسات التجريبية من خلال تسليط الضوء على إمكانية المزج المتناغم بين التقاليد والحداثة.
Propagation by stem cutting of Euphorbia balsamifera (Aiton), a galactogenic plant in Benin
Authors: Diane Bernice Biaou Olaïtan , Balogoun Ibouraïman , Daouda Bello Orou , Chabi Faki , Saïdou Aliou , Léonard Ahoton Essèhou
Published: April 2024

Objectives: Cutting is a method of asexual vegetative plant propagation that allows new plants from a plant cuttings cut from the mother plant. The present study aims to test this plant reproduction method using cuttings of the stem of Euphorbia balsamifera for the domestication of the species as it induces milk production in cows. Methodology and results: The experiment was carried out on the experimental site of the botanical garden of University of Abomey-Calavi in southern Benin. The Euphorbia balsamifera’s stem of 15 and 25 cm of length were planted in two different substrates: soil alone and mixture of soil + compost for rooting. The mixture of soil + compost was used in a ratio of 3/4 of soil and 1/4 of compost. The experimental design used was a split plot with four replications. The main factor was the stem length and sub factors were type of substrate. The results revealed that the substrate and stem cuttings length of plant material induced significant (p < 0.01 to p < 0.001 respectively) effect on the proportion (85%) of stem cuttings that were recovered. The stem cuttings with the length 25 cm planted in the soil alone reduced the duration of stem cuttings recovered (7.00±0.00 days). Conclusion and application of findings: Stem cuttings (length 25 cm) transplanted in soil alone was the efficient way of regeneration of Euphorbia balsamifera. This finding is suggested to the agro-pastoralists to enhance milk production of cows. This study is the first step in the process of domestication of the species. However, propagation by stem of this galactogenic plant species could also be tested during different seasons of the year in order to determine the best plantation period in the field in a context of in situ and ex situ conservation. Keywords: Budburst, cuttings, domestication, lactogenic plant, biodiversity conservation.
Distance function approaches for efficiency analysis of organic production units: a critical review
Authors: Ahlonsou Ceptime , Sodjinou Epiphane , Glèlè Kakaï Romain
Published: April 2024

Objectives: This review aims to make a comprehensive synthesis of distance function methods for the efficiency analysis of organic production units. Methodology and Results: The study reviewed and summarized the different approaches of distance functions applied in organic farming systems to assess performance. Original articles covering ten years, from 2010 to 2020 were identified through keyword searching using web search engines. After careful reading of the abstracts, 20 papers were finally retained. The selected papers were categorized based on study purpose and findings. Results showed a gap between the development of distance function methods and their usage in organic farming efficiency analysis. Four distance function methods were identified, and the most used in organic farming efficiency analysis were output distance function (40%) and directional output distance function (25%). Conclusion and application of findings: Results indicate that distance functions are powerful tools in modelling multi-input and multi-output production technology for assessing organic farming efficiency. Future research should focus on these methods to deepen their understanding and applications. Keywords: Distance function, efficiency analysis, literature review, organic farming