bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Maternal Education and Encouragement on Newborn Care Utilization: A Health System Intervention
Authors: Kolahi Ali-Asghar , Abbasi-Kangevari Mohsen , Abadi Alireza
Published: March 2021

Background: The objective of this health system interventional study was to determine the effect of delivering newborn-care-oriented education and encouragement to receive newborn care on newborn care utilization.Methods: This study was performed in the urban health centers of the catchment area of Tehran Defined Population, which covered 10 of the 22 municipality districts of Tehran. The two catchment areas included 10,000 families in the intervention and 20,000 families in the control areas. As many as 4837 newborns (intervention=1544, control=3293) were enrolled and followed until the end of the second month of life. The utilization of newborn care was compared among the intervention and control groups. Results: Almost 99.6% in the intervention group and 99.5% in the control group did their screening tests. The mean number of newborn care visits was higher in the intervention group compared to the control group: 2.26 (0.99) versus 1.84 (1.07), p<0.001. Newborns' attendance in the first newborn care visit was more among newborns who were born through normal birth compared to those who were born through the caesarian section: 51.2% CI [48.1, 54.3] versus 38.6%; 95% CI [37.1, 40.2], p<0.001. Conclusions: The intervention improved newborn care utilization during the first two months after birth. It could be suggested that active follow-up be added to newborn care guidelines, and parents be informed of the necessity and benefits of newborn care and be encouraged to perform all three newborn care visits.
Sorafenib for Desmoid Tumors. A Cost Analysis: Too Much for Too Little?
Authors: Johns Michael S. , III William Merritt , Rhodes Lori , Ford Candice N. , Thompson Mark , Lee William M. , Petrelli Nicholas J. , Tiesi Gregory J.
Published: March 2021

Background: A recent randomized trial showed that sorafenib increased progression free survival (PFS) in patients with desmoid tumors despite many patients experiencing stable disease or spontaneous regression without treatment. Using these trial data, we completed a cost analysis of sorafenib efficacy through two years of treatment. Methods: 2019 Medicare Part D rates for sorafenib were used (dose 400 mg/day, cost $309/day). Yearly costs per progression and objective response were calculated. Radiologic progression and response were defined using Response Evaluation Criteria in Solid Tumors (RECIST). Patients with disease progression were separately analyzed in two groups: both clinical and radiologic (CAR), and radiologic alone. Results: 84 previously randomized patients were analyzed (placebo: 35, sorafenib: 49). After 1 year, sorafenib was associated with 43% absolute risk reduction (ARR) of CAR progression and number-needed-to-treat (NNT) of 2.3 patients/year, costing $259,406. After 2 years, ARR was 48% and NNT of 2.1 patients/year, costing $473,697. When assessing only patients with RECIST defined radiologic progression, sorafenib patients had ARR of 13.9% with NNT 7.2 and estimated costs of $812,052 at one year. Two-year ARR was 17.5% with NNT 5.7 and estimated costs $1,285,052. Sorafenib patients experienced improved RECIST partial response rates at 1 and 2 years of 14.7% and 14.3%, with NNT 6.8 and 6.9, and costs of $766,938 and $1,556,433; respectively. Conclusion: For the treatment of desmoid tumors, Sorafenib led to improved PFS, but at a substantial cost per patient. Beneficial RECIST outcomes were less likely and at higher cost. Patients should be informed of possible benefits of treatment versus potential financial burden.
Intravenous compounding robots in pharmacy intravenous admixture services: a health technology assessment
Authors: zhang lingli , yang chunsong , Peng Lijuan , Ni Xiaofeng
Published: March 2021

Background

This study was performed to conduct a health technology assessment of intravenous compounding robots and provide the currently available best evidence for hospital decision-makers.
Methods

A comprehensive search of relevant professional health technology assessment websites and electronic databases (Embase, PubMed, The Cochrane Library, CNKI, VIP, CBM, and Wanfang Database) was conducted from inception to 11 August 2020. Two reviewers independently screened literature according to the inclusion and exclusion criteria and extracted data. The results were reported by qualitative description because of heterogeneity in the characteristics of the data in the included studies.
Results

Forty studies were included: 2 health technology assessments, 24 control studies (6 randomized controlled trials, 13 non-randomized contemporaneous controlled trials, and 6 non-randomized historical controlled trials), 12 non-controlled studies (11 single-arm studies, 1 investigation report), 1 qualitative study (in-depth interview), and 1 economics research. Effectiveness: The robots improved the production efficiency compared with usual/manual preparation; however, the intravenous preparation process requires further optimization. Additionally, robots reduced the incidence of medicine residues, preparation errors, and preparation failures. The accuracy and solution properties of intravenous admixture medicines were satisfactory, and the robots also contributed to error recognition. Safety: The robots reduced product pollution and environmental pollution, but vigilance is still required to ensure that pollution stays low. The robots also reduced the incidence of health damage to technicians. Economy: The robots reduced material costs in these studies; however, whether they can reduce labor costs remains unclear. Social suitability: Technicians had a high degree of satisfaction with the robots, but few relevant studies focused on this aspect.
Conclusion

Intravenous compounding robots have certain advantages in terms of safety, effectiveness, economy, and social adaptability. High-quality and large-sample randomized controlled trials or well-designed observational studies are still needed to evaluate such robots, especially in terms of economic and social suitability.
Size-dependent growth tactics of a partially migratory fish before migration
Authors: Futamura Ryo , Morita Kentaro , Kanno Yoichiro , Kumikawa Shoji , Matsuoka Yuichi , Okuda Atsushi , Sugiyama Hiroshi , Takahashi Hiroyuki , Uchida Jiro , Kishida Osamu
Published: March 2021

For migratory species, attaining enough large size before migration is a key mechanism of individuals for their success in risky migration. Since the smaller migrants suffer from high mortality during migration, prospective migrants with smaller size should grow better than larger ones before migration. To test this prediction, we investigated size-dependent patterns of the two growth mechanisms (i.e., growth rate and duration) of juvenile masu salmon (Onchorynchus masou) before their oceanic migration. Masu salmon exhibit a partial migratory strategy, in which single population consists of oceanic migrants and river-dwelling residents. Our individual mark-recapture survey and assessment of the river-descending timing by PIT-tag antenna-reader system revealed that patterns of growth rate in the pre-migration period and the timing of migration correspond with our predictions. For around half-year before outmigration (i.e., between after decision of migration and before start of migration), the prospective migrants showed the size-dependent growth rate, in which individuals with smaller size exhibited higher growth rate than those with larger size, but the residents showed the size-independent growth rate. In addition, the prospective migrants showed the size-dependent timing of outmigration, in which individuals with smaller size delayed the migration timing than those with larger size, to lengthen the duration of pre-migration period. These results suggest that size-selective mortality during migration has shaped size-dependent adjustment of the pre-migration growth in migratory masu salmon. Conditional changes in growth rate and duration of pre-migration period may be an adaptive tactic for the migratory animals.
Hydrodynamics of Direct Contact Condensation Process in Desuperheaters
Authors: Khan Afrasyab , Sanaullah Khairuddin , Rigit Andrew Ragai Henry , Ullah Atta
Published: March 2021

Due to the global warming and environmental implications, the focus of household heating has shifted from fossil fuels towards environmentally friendly and renewable sources. Desuperheaters have been found an attractive option as a domestic provision for the warm water; they used steam induced direct contact condensation (DCC) as the major means to warm the water. The present study has been an attempt to investigate the hydrodynamics in the Desuperheater vessel experimentally, when the pressurized pulsating steam was injected into the vessel, where, the steam jet interacted co-currently with the slow-moving water. Visual flow visualization provided an overall flow picture that showed a circulation region when the pulsating steam was injected into the slow co-currently moving water and the peaked vorticity corresponded to the steam injection duration varying from 10-60 seconds. An array of 7 Hot Film Anemometers (HFA) was traversed axially and radially to determine the velocity fluctuations at 0 – 20 cm from the steam's nozzle exit. Vortical structures were obtained that corresponded to the entrainment of the steam with the surrounding cocurrently moving water. The circulation regions were thus exhibited in relation to the steam's injection durations as well as the downstream axial distance of 2 cm and 15 cm from the nozzle exit, which showed that the core local circulation at 2 cm, lost 75-79% of its circulation at 15 cm downstream of the nozzle exit.
ПЕРСПЕКТИВЫ УЛУЧШЕНИЯ СПЕЦИАЛИЗИРОВАННОЙ ПОМОЩИ ПАЦИЕНТАМ С НЕСПЕЦИФИЧЕСКИМИ ГНОЙНЫМИ ЗАБОЛЕВАНИЯМИ ПОЗВОНОЧНИКА
Authors:   Свердловская областная клиническая больница № 1, Гончаров Максим Юрьевич , Горева Яна Алексеевна ,   Уральский государственный медицинский университет
Published: March 2021

The problem of early diagnosis of non-specific purulent diseases of the spine remains relevant. The main organizational problems in providing medical care to these patients are considered to be late diagnosis, late administration of antibacterial therapy and neurosurgical care. The goal of our work was to improve treatment outcomes by reducing the time of diagnosis and the duration of the stage before providing specialized care. Based on the identified variable factors that influenced the treatment outcomes, we proposed an algorithm for the diagnosis and treatment of non-specific purulent diseases of the spine, implemented in the activities of hospitals in the Sverdlovsk region. To evaluate the effectiveness of our proposed algorithm, we retrospectively compared the main indicators and results of the treatment of patients conducted before and after the implementation of the developed algorithm. Educational and methodological work with doctors was also important for reducing the time of diagnosis of the disease. After the implementation of the developed algorithm of diagnostics and tactics in nonspecific suppurative diseases of the spine and the necessary organizational issues, there was a reduction of the duration from the first signs of the disease to provide specialized assistance, as well as the number of patients who had gross neurological deficit and/or systemic inflammatory response syndrome upon admission to a hospital. The results obtained allow us to recommend the developed algorithm of diagnostics and tactics for non-specific purulent diseases of the spine for implementation in other regions of the Russian Federation.
Membingkai Risma di Portal Berita Online: Jejak Penanganan Covid-19 di Surabaya
Authors:   Universitas Pembangunan Nasional “Veteran” Jawa Timur, Khoirulla Annas K , Abiyu Sulthan ,   Universitas Pembangunan Nasional “Veteran” Jawa Timur, Raihan Sheila AT ,   Universitas Pembangunan Nasional “Veteran” Jawa Timur, Febrianita Roziana ,   Universitas Pembangunan Nasional “Veteran” Jawa Timur
Published: March 2021

Keputusan Pemerintah yang menetapkan Covid-19 sebagai bencana nasional turut memengaruhi kebijakan penanganan bencana di daerah, terutama di Kota Surabaya. Kebijakan Walikota Surabaya, Tri Rismaharini seringkali diberitakan media online sebagai ajang pertaruhan kepentingan kepala daerah. Studi ini berupaya menggali peran pemimpin perempuan dalam mengatasi Covid-19 dan kebijakan penanganan di saat pandemi. Berita dua media online, Kompas.com dan Detik.com, dikumpulkan sepanjang Mei-Oktober 2020 untuk dianalisa dengan menggunakan metode framing model Entman. Tujuannya untuk memahami penggambaran performa pemimpin perempuan yang ditonjolkan dalam proses pemberitaan, penggunaan argumentasi, memperkuat pemberitaan serta menemukan dan menyelesaikan setiap permasalahan terkait virus Corona. Hasil penelitian ini menemukan bahwa Detik.com dan Kompas.com menggambarkan Tri Rismaharini dalam penanganan Covid-19 secara kompeten dan memenuhi syarat untuk penyebaran informasinya melalui portal berita. Detik.com membingkai beberapa informasi dengan kesan tidak memihak pada siapapun dan natural dalam menyampaikan informasi serta isu-isu yang diangkat. Sedangkan Kompas.com sangat memperhatikan dalam menentukan siapa narasumber yang dipilih untuk memperkuat informasi yang dipaparkannya.
Social Media Engagement and Influenza Vaccination During the COVID-19 Pandemic: Cross-sectional Survey Study
Authors: Benis Arriel , Khodos Anna , Ran Sivan , Levner Eugene , Ashkenazi Shai
Published: March 2021

Background

Vaccines are one of the most important achievements of modern medicine. However, their acceptance is only partial, with vaccine hesitancy and refusal representing a major health threat. Influenza vaccines have low compliance since repeated, annual vaccination is required. Influenza vaccines stimulate discussions both in the real world and online. Social media is currently a significant source of health and medical information. Elucidating the association between social media engagement and influenza vaccination is important and may be applicable to other vaccines, including ones against COVID-19.

Objective

The goal of this study is to characterize profiles of social media engagement regarding the influenza vaccine and their association with knowledge and compliance in order to support improvement of future web-associated vaccination campaigns.

Methods

A weblink to an online survey in Hebrew was disseminated over social media and messaging platforms. The survey answers were collected during April 2020. Anonymous and volunteer participants aged 21 years and over answered 30 questions related to sociodemographics; social media usage; influenza- and vaccine-related knowledge and behavior; health-related information searching, its reliability, and its influence; and COVID-19-related information searching. A univariate descriptive data analysis was performed, followed by multivariate analysis via building a decision tree to define the most important attributes associated with vaccination compliance.

Results

A total of 213 subjects responded to the survey, of whom 207 were included in the analysis; the majority of the respondents were female, were aged 21 to 40 years, had 1 to 2 children, lived in central Israel, were secular Israeli natives, had higher education, and had a salary close to the national average. Most respondents (128/207, 61.8%) were not vaccinated against influenza in 2019 and used social media. Participants that used social media were younger, secular, and living in high-density agglomerations and had lower influenza vaccination rates. The perceived influence and reliability of the information on social media about COVID-19 were generally similar to those perceptions about influenza.

Conclusions

Using social media is negatively linked to compliance with seasonal influenza vaccination in this study. A high proportion of noncompliant individuals can lead to increased consumption of health care services and can, therefore, overload these health services. This is particularly crucial with a concomitant outbreak, such as COVID-19. Health care professionals should use improved and targeted health communication campaigns with the aid of experts in social media. Targeted communication, based on sociodemographic factors and personalized social media usage, might increase influenza vaccination rates and compliance with other vaccines as well.
Sensitivity Treatments for Teeth with Molar Incisor Hypomineralization: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Mendonça Fernanda L , Regnault Fabiana Giuseppina Di Campli , Di Leone Camilla C L , Grizzo Isabella C , Bisaia Aliny , Fragelli Camila , Oliveira Thais M , Magalhães Ana C , Rios Daniela
Published: March 2021

BACKGROUND

The sensitivity of teeth with molar incisor hypomineralization (MIH) can affect children’s quality of life and is a challenging problem for dentists. Remineralizing agents such as sodium fluoride varnish seem to reduce the sensitivity of teeth with MIH, but long-term clinical trials with large samples are still needed for more evidence about its effectiveness as a desensitizing agent before its clinical recommendation.

OBJECTIVE

This randomized clinical trial aims to compare three treatment interventions for teeth with MIH and hypersensitivity.

METHODS

A total of 60 children aged 6-10 years presenting with at least one first permanent molar with sensitivity and no loss of enamel will be randomly assigned to three groups: the control group (sodium fluoride varnish; Duraphat, Colgate); experimental group I (4% titanium tetrafluoride varnish); and experimental group II (a coating resin containing surface prereacted glass-ionomer filler; PRG Barrier Coat, Shofu). The sodium fluoride varnish and 4% titanium tetrafluoride varnish will be applied once per week for 4 consecutive weeks and the PRG Barrier Coat resin will be applied in the first session and the application will be simulated the following 3 weeks to guarantee the blinding of the study. The primary outcome will be sensitivity level measured at different moments (before each material application, immediately after application or simulation, and 1, 2, 4, and 6 months after the last application/simulation) by one examiner using the Wong-Baker FACES Pain Rating Scale, the Schiff Cold Air Sensitivity Scale, and the FLACC (Face, Legs, Activity, Cry, Consolability) scale. As secondary outcomes, parental satisfaction and child self-reported discomfort after the treatment will be measured with a questionnaire prepared by the researcher. The data will undergo statistical analysis and the significance level will be set at 5%.

RESULTS

The project was funded in 2018, and enrollment was completed in November 2019. The recruitment of participants is currently underway and the first results are expected to be submitted for publication in 2022.

CONCLUSIONS

If found effective in reducing the patient’s sensitivity long term, these agents can be considered as a treatment choice, and the findings will contribute to the development of a treatment protocol for teeth with sensitivity due to MIH.

CLINICALTRIAL

Brazilian Registry of Clinical Trials Universal Trial Number U1111-1237-6720; https://tinyurl.com/mr4x82k9

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/27843
The Associations Between Mental Health Problems and Attitudes Toward Web-Based Health and Social Care Services: Evidence From a Finnish Population-Based Study (Preprint)
Authors: Rantanen Teemu , Gluschkoff Kia , Silvennoinen Piia , Heponiemi Tarja
Published: March 2021

BACKGROUND

The significance of web-based health and social care services has been highlighted in recent years. There is a risk that the digitalization of public services will reinforce the digital and social exclusion of vulnerable groups, such as individuals with mental health problems.

OBJECTIVE

This study aims to examine the associations between mental health problems and attitudes toward web-based health and social care services in the general population. The attitudes measured include lack of interest, perceived need for face-to-face encounters, and concern for safety. The study also evaluates whether sociodemographic characteristics (age, gender, education level, and poverty) modify these associations.

METHODS

Cross-sectional population-based data were collected from 4495 Finnish adults in 2017. Linear regression was used to examine the main effects and interactions of poor mental health and sociodemographic characteristics on attitudes toward web-based health and social care services.

RESULTS

The results show that mental health was associated with attitudes toward web-based health and social care services. Individuals with mental health problems were especially concerned about the safety of web-based services. Poor mental health was independently associated with negative attitudes toward web-based services over the effects of sociodemographic factors. Some of the associations between poor mental health and negative attitudes toward web-based services were stronger among older people and men. With regard to sociodemographic characteristics, particularly higher age, low education, and poverty were associated with negative attitudes toward web-based health and social care services.

CONCLUSIONS

Poor mental health is associated with negative attitudes toward web-based health and social care services and thus indirectly with exclusion. It seems that being older and being male both reinforce the link between poor mental health and exclusion. In supporting the digital inclusion of people with mental health problems, attention should be paid to guidance and counseling, reliability, and the user-friendliness of web-based services as well as to the prevention of poverty. In addition, it is essential to see web-based services as complementary to, and not a substitute for, face-to-face services.

CLINICALTRIAL
Medical Students Learning on the COVID-19 Front Line (Preprint)
Authors: Zimianiti Ioanna , Thanaraaj Vyshnavi , Watson Francesca , Osibona Oluwapelumi
Published: March 2021

UNSTRUCTURED

In this viewpoint, we share our perspectives, as medical students at Imperial College London, on our experiences during our Infectious Diseases placement at Northwick Park Hospital, touching upon other students’ experiences at other sites as well. We highlight some of the main drivers of and barriers to medical students seeing patients with COVID-19.
Stakeholders’ Perspectives on eHealth Support in Colorectal Cancer Survivorship: Qualitative Interview Study (Preprint)
Authors: Husebø Anne Marie Lunde
Published: March 2021

BACKGROUND

eHealth interventions may represent the way forward in following up patients with colorectal cancer (CRC) after hospital discharge to support them in coping with the illness, strengthen their self-management, and increase their quality of life. By involving end users of eHealth in cocreation processes when designing eHealth solutions, an acceptable and relevant product can be secured. Stakeholders’ perspectives could aid in closing the gap between research-developed products and the implementation of eHealth services in real-life scenarios.

OBJECTIVE

This study aims to explore the views of patients with CRC, their informal caregivers, and health care professionals (HCPs) on information technology and the design of eHealth support in CRC care.

METHODS

A qualitative, explorative design was used to conduct 31 semistructured individual interviews with 41% (13/31) patients with CRC, 29% (9/31) informal caregivers, and 29% (9/31) HCPs recruited from the gastrosurgical ward of a university hospital in southwestern Norway. A semistructured interview guide was used for data collection, and the data were analyzed by systematic text condensation.

RESULTS

Participants described the diverse experiences of patients with CRC seeking web-based information. Age and digital competence were highlighted as influencers of the use of information technology. Patients rarely received advice from HCPs about relevant and secure websites containing information on CRC diagnosis and treatment. Features of desired eHealth interventions in following up patients with CRC were patient education, health monitoring, and communication with HCPs.

CONCLUSIONS

Several elements affect the activities of patients with CRC seeking health information. Age, inexperience with computer technology, and lack of access to web-based health information may reduce the ability of patients with CRC to engage in decision-making processes regarding illness and treatment. An eHealth service for patients with CRC should comprise features for information, education, and support for self-management and should aim to be individually adapted to the patient’s age and digital competence. Involving end users of eHealth services is necessary to ensure high-quality tailored services that are perceived as user friendly and relevant to the end users.
Methodological Guidelines for Systematic Assessments of Health Care Websites Using Web Analytics: Tutorial (Preprint)
Authors: Fundingsland Jr Edwin Lauritz , Fike Joseph , Calvano Joshua , Beach Jeffrey , Lai Deborah , He Shuhan
Published: March 2021

UNSTRUCTURED

With the growing importance of communicating with the public via the web, many industries have used web analytics to provide information that organizations can use to better achieve their goals. Although the importance of health care websites has also grown, the health care industry has been slower to adopt the use of web analytics. Web analytics are the measurement, collection, analysis, and reporting of internet data used to measure direct user interaction. Our objective is to provide generalized methods for using web analytics as key performance metrics to evaluate websites and outline actionable recommendations for improvement. By deconstructing web analytic categories such as engagement, users, acquisition, content, and platform, we describe how web analytics are used to evaluate websites and how improvements can be made using this information. Engagement is how a user interacts with a website. It can be evaluated using the daily active users to monthly active users (DAU/MAU) ratio, bounce rate, pages viewed, and time on site. Poor engagement indicates potential problems with website usability. Users pertains to demographic information regarding the users interacting with a website. This data can help administrators understand who is engaging with their website. Acquisition refers to the overall website traffic and the method of traffic, which allows administrators to see how people are accessing their website. This information helps websites expand their methods of attracting users. Content refers to the overall relevancy, accuracy, and trustworthiness of a website’s content. If a website has poor content, it will likely experience difficulty with user engagement. Finally, platform refers to the technical aspects of how people access a website. It includes both the internet browsers and devices used. By providing detailed descriptions of these categories, we have identified how web administrators can use web analytics to systematically assess their websites. We have also provided generalized recommendations for actionable improvements. By introducing the potential of web analytics to augment usability and the conversion rate, we hope to assist health care organizations in better communicating with the public and therefore accomplishing the goals of their websites.
Tipo de vivienda, barreras físicas y sensación de inseguridad en la colonia
Authors: Vilalta Carlos , Jasso Lucía Carmina , Fondevila Gustavo
Published: March 2021

En este estudio analizamos si el tipo de vivienda y las barreras físicas colocadas entre la calle y la entrada de la misma mantienen una relación estadística con la sensación de inseguridad en el entorno de la colonia. Los resultados sugieren rechazar tal hipótesis por no existir evidencia. Esta investigación permite al lector conocer los correlativos que se asocian con la sensación de inseguridad en la colonia. Para la realización de este análisis se utilizaron pruebas bivariadas y modelos multivariados; asimismo, se recabaron datos de la Encuesta Nacional de Victimización y Percepción sobre Seguridad Pública.
Agroturismo: ¿oportunidad y desafío para el Valle de San Quintín, Baja California, México?
Authors: Jaimes Maruri Karla Cecilia , Morales Zamorano Luis Alberto , Jasso-Arriaga Xochitl
Published: March 2021

El agroturismo consiste en la realización de actividades productivas y recreativas en un solo espacio, lo cual genera ingresos extraordinarios; por consiguiente, se identificaron los componentes del agroturismo para incluirlos en un proyecto y establecer si es una oportunidad o desafío desde su gestión en el Valle de SanQuintín, Baja California, México. Se utilizó el método exploratorio. Se registraron cuatro elementos del agroturismo. El 64% de empresarios mostró interés en complementar actividades productivas con actividades agroturísticas. La oportunidad debe enfocarse en acciones positivas a fin de generar beneficios adicionales y el desafío debe establecer estrategias ante situaciones adversas.
Análisis de la evolución espacio-temporal del uso de suelo urbano en la metrópolis de Chihuahua
Authors: Dávila Rodríguez Antonio , Alatorre Cejudo Luis Carlos , Bravo-Peña Luis Carlos
Published: March 2021

La presente investigación tiene como objetivo la monitorización del cambio en los patrones de distribución espacial del uso del suelo urbano que se ha presentado en la zona de presión intermunicipal de Chihuahua en el periodo 1995-2015. Se utilizó el software FRAGSTATS para el cálculo de las métricas de análisis de la ecología del paisaje. Los resultados indican que el crecimiento del suelo destinado a vivienda que se presentó en el periodo de estudio se encuentra en consonancia con el modelo de ciudad dispersa, caracterizado por la baja densidad edificatoria y la preponderancia del transporte privado por carretera.
Resiliencia de los municipios costeros del Pacífico mexicano ante desastres socionaturales
Authors: Velázquez-González Karen , Adame-Martínez Salvador , Hoyos Castillo Guadalupe , Seingier Georges
Published: March 2021

Este estudio determinó, mediante un índice constituido por 24 indicadores, congregados en tres índices de segundo orden: prevención, resistencia y recuperación, la resiliencia ante desastres socionaturales de municipios costeros del Pacífico mexicano. La resiliencia encontrada fue mayormente media debido a una capacidad de recuperación endeble. Un análisis clúster precisó cinco grupos con características propias de resiliencia, resaltó uno de mayor rezago en Oaxaca y Guerrero debido a su bajo nivel de prevención y recuperación, los hallazgos permiten a quienes toman decisiones orientar estrategias y priorizar acciones para aumentar la resiliencia ante las amenazas naturales en el territorio mexicano.
Callus induction and secondary metabolite profile from Elephantopus scaber L.
Authors: Junairiah Junairiah , Wulandari Diah Ayu , Utami Edy Setiti Wida , Zuraidassanaaz Nabilah Istighfari
Published: March 2021

Elephantopus scaber L. is a plant that has potential as traditional medicine. Callus induction and production of secondary metabolite content can be increased by culture callus using plant growth regulators. This study was purposed to investigate the effect of IBA and kinetin concentration on the induction and secondary metabolite profile of callus from E. scaber L. leaves. Leaves explant of E. scaber L. were cultured on MS medium with various combination concentrations of IBA and kinetin for 6 weeks and then callus was extracted using methanol.  Secondary metabolite content from the resulting extract was analyzed using the phytochemical screening method. The result showed that the treatment of IBA 2.0 mg/L and kinetin 1.0 mg/L and treatment of IBA 2.0 mg/L and kinetin 2.5 mg/L are the fastest combination concentration to induce callus at 5.33 ± 0.577 days. Treatment of IBA 2.0 mg/L and kinetin 2.5 mg/L produced callus with the highest fresh weight and dry weight at 0.7016 ± 0.0588 grams and 0.0766 ± 0.0062 grams, respectively. The morphology of calluses grown during this study was compact with various colors appearance, such as light green, brownish green, and brown. Secondary metabolite content of methanol extract of callus E. scaber L. are flavonoids, alkaloids, terpenoids, and saponins.
Composite Abstract Lexical Structure in Interlanguage Production
Authors: Liu Xuexin , Wei Longxing
Published: March 2021

Most previous studies of difficulties in learning a second/foreign language focused on sources of learner errors caused by cross-linguistic differences in various levels of linguistic structure, but most of such studies remain at a rather superficial level of description. This study explores sources of learning difficulties at an abstract level by studying the nature and activity of the bilingual mental lexicon during interlanguage production. The bilingual mental lexicon is defined as the mental lexicon containing abstract entries called cross-linguistic “lemmas” underlying particular lexeme. This study claims that it is language-specific lemma which drives interlanguage production at three levels of abstract lexical structure: lexical-conceptual structure, predicate-argument structure, and morphological realization patterns. It further claims that it is cross-linguistic lemma variations in abstract lexical-conceptual structure which result in not only inappropriate lexical choices but also errors in interlanguage production of target language predicate-argument structure and morphological realization. Naturally occurring interlanguage production date for the study include several native and target language pairs: Japanese-English, Chinese-English, and English-Japanese. Some typical instances of language transfer involving other language pairs are also cited in support of the argument that the lexical-conceptual approach to interlanguage production is fundamental in any study of the nature of learner errors in interlanguage development.
SECONDARY MITOCHONDRIAL DYSFUNCTION
Authors: KHAJURIA KANIKA , KHAJURIA VIJAY , SAWHNEY VINEETA
Published: March 2021

Mitochondria are the most vital organelle in the cell because of its multitask properties. They are well known for the production of energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), which involves multiple complexes and cofactors. Mitochondria in addition to ATP production, also perform other vital functions like generation of reactive oxygen species (ROS), antioxidants, apoptosis, signaling and hormone actions.

Because of their multiple actions, it is quite expected that their dysfunction will result in the number of effects. Since most vital organs exclusively depend on ATP to perform their functions, therefore impediment in its supply resulting from mitochondrial dysfunction will be detrimental and have a widespread spectrum. Neurodegenerative disorders, Huntington’s disease, cardiovascular disease (CVD), epilepsy, aging, metabolic syndrome, diabetes, autism, muscular atrophy, lou gehrig’s disease, neoplasia, down syndrome are few instances where mitochondrial dysfunction is the basic cause in pathogenesis.

Mitochondrial disorders are either Primary or secondary disorders. Primary mitochondrial disease or disorder (PMD) has mitochondrial or nuclear deoxyribonucleic acid (mt DNA or nDNA) mutation affecting oxidative phosphorylation (OXPHOS). While Secondary mitochondrial dysfunction (SMD) does not involve OXPHOS but is the result of mutations in non OXPHOS genes. Secondary mitochondrial dysfunction (SMD) can also be acquired secondary to adverse factors those cause oxidative stress.

All this highlights the role of mitochondria and makes it a new therapeutic target in managing these disorders. The present review has briefly discussed the secondary mitochondrial dysfunctional disorders and the approach to tackle it.
A PROSPECTIVE STUDY OF THE IMPACT OF MICROBIOLOGICAL CULTURES ON ANTIBIOTIC PRESCRIBING PATTERN IN A TERTIARY CARE HOSPITAL
Authors: VACHHANI PARTH , SINGH ANIL
Published: March 2021

Objective: Antibiotics are frequently prescribed because of clinical suspicion of infection, while the results of the microbiological analysis are still awaited. This study was undertaken to assess the impact of microbiological culture results on the antibiotic prescribing pattern.

Methods: This prospective observational study was conducted on 400 patients of either sex and any age with positive microbiological culture results. Empirical antibiotic therapy details were recorded and change in empirical antibiotic therapy after positive culture results was also recorded. Assessment of sensitivity resistance pattern of microorganisms was also performed.

Results: In the study, male: female ratio was 1.01:1. The majority of patients i.e. 94 (24.50%) were in the 46 y to 60 y of age group. Definitive antibiotic therapy was initiated in 103 patients (25.75%) out of 400 patients. The highest number of changes in antibiotic therapy was done in urinary tract infections (63.95%) and septicemia (32.61%) cases. Klebsiella (34.25%), E. coli (32%) and Staphylococcus aureus (14.75%) were commonly isolated microorganisms. Cephalosporins (77.75%) and aminoglycosides (47%) were commonly used in empirical antibiotic therapy, while nitrofurantoin (47.57%) and penicillins (22.33%) were commonly used in definitive antibiotic therapy. Definitive antibiotic therapy was associated with a reduced duration of hospital stay as compared to empirical antibiotic therapy (p<0.0001).

Conclusion: Antibiotic prescribing is infrequently influenced by microbiological culture results. Adjustment of the antimicrobial therapy according to microbiological culture results can decrease the duration of hospital stay as well as can decrease the spread of antimicrobial resistance.
HASIL PENGELOLAAN HOMESTAY BERCORAK BUDAYA DITENGAH PENGARUH PERKEMBANGAN TREND MILLENNIAL DI SEKTOR PARIWISATA
Authors: Pradana Gede Yoga Kharisma , Arcana Komang Trisna Pratiwi
Published: March 2021

Karya tulis ilmiah ini membahas tentang capaian dari pengelolaan Homestay Bercorak Budaya Tradisional Bali dalam perkembangan pariwisata. Publikasi ini disusun berdasarkan penggunaan metode kualitatif. Semua data penelitian diperoleh melalui observasi, studi pustaka, dan wawancara dengan pemerhati pariwisata Bali, pemilik homestay dan pengurusnya di Ubud. Semua data dianalisis dengan menerapkan teori fungsi dan teori praktik. Hasil penelitian menunjukkan bahwa hasil pengelolaan Homestay bercorak Budaya Tradisional ditengah Pengaruh Trend Millennial di sektor pariwisata berupa bangunan pondok yang disusun berdasarkan prinsip arsitektur tradisional Bali bagi wisatawan. Sebagai akomodasi wisata, Homestay bercorak budaya tradisional Bali mengandalkan keindahan dan keasrian lingkungan rumah khas Bali.
Concept and Meaning of Evaluating Evidence in Criminal Proceedings
Authors:   Saint Petersburg University of the Ministry of Internal Affairs of Russia, Bykadorova E.V.
Published: March 2021

Opinions of various scientists on the concept and meaning of assessment of evidence are considered. Evaluation of evidence, without which it is impossible to conduct a preliminary investigation, judicial proceedings, make lawful and sound procedural decisions and the correct application of the law, are analyzed. It is proved that the lack of sufficient methodological and terminological basis leads to judicial errors.
La historia olvidada (la lobotomía)
Authors: Paláu Castaño Luis Alfonso
Published: March 2021

Traducción del francés al español de Luis Alfonso Paláu-Castaño

«El psicoanálisis nació en el campo de las neurosis y como una práctica de ciudad. Es tanto como decir que él se interesa, en primer lugar, en los trastornos mentales menos graves, es decir, los que no entrañan una hospitalización. Las patologías graves, bajo el nombre de psicosis (como la esquizofrenia o la psicosis maniacodepresiva) hacen parte de un campo al que ella desea anexarse, pero la partida se revela ruda. Es precisamente después de la guerra que se comienza a hablar mucho de “psicoanálisis de las psicosis”. Pero “hablar mucho” no es igual a “encargarse”. Sin embargo, los psicoanalistas están entonces convencidos de que su competencia va a extenderse poco a poco al campo de las psicosis.»
J. J. Grandville y la semiósis corporizada del gesto estético. A propósito de las caricaturas que integran la revista Ciencias Sociales y Educación n.º 18
Authors: Cardona-Rodas Hilderman
Published: March 2021

«Grandville es el autor de los siguientes libros ilustrados con sus litografías satíricas: Les Plaisirs de toutdge, La Sibylle des salons, Les Métamorphoses du jour, La Vie privée et publique des animaux, Les Cent Proverbes, Un Autre Monde y Les Fleurs animées. En cada una de estas obras, le da forma a una pregunta por la corporalidad de la condición humana en las expresiones de sus emociones. Así, en su obra las huellas de la rostridad se hacen visibles en un régimen satírico que mezcla cuerpo humano y rostros animales.»
FLOW SHOP SCHEDULING BASED ON PALMER-NEH, GUPTA-NEH AND DANNENBRING-NEH ALGORITHMS TO MINIMIZE THE ENERGY COST
Authors: Masrikhan Masrikhan , Kurniawati Dwi Agustina
Published: March 2021

In the manufacturing industry, the most widely used equipment is equipment that uses electricity. Electricity cost is one of the highest operational production costs after labor cost. So, it is very important to save and optimize the use of electrical equipment. One of the manufacturing industries is Taru Martani, Ltd. This research aims to minimize the energy cost by proposing three hybrid algorithms, namely Palmer-NEH, Gupta-NEH, and Dannenbring-NEH methods. Some scheduling evaluation is done using the Efficiency Index (EI) and Relative Error (RE) parameters. It is concluded that the Palmer-NEH and Gupta-NEH methods are the best methods with the lowest energy cost compared with company's actual method and the Dannenbring-NEH method. Based on the Palmer-NEH and Gupta-NEH methods, both methods can save the makespan up to 399.13 minutes or 6.65 hours compared with the company's actual method. With these methods, the company is also able to save the production cost by Rp. 818,043.00.
THE VISUALISATION OF MUHAMMADIYAH MUSEUM USING AUGMENTED AND VIRTUAL REALITY TECHNOLOGY
Authors: Putra Fijaya Dwi Bima Sakti , Umar Rusydi , Sunardi Sunardi
Published: March 2021

There is a lot of media for promotion. The brochure is still widely used because of its simple, portable, and easy to carry anywhere. However, in this age of sophistication, the brochure is not effectively used for the millennial generation. Augmented Reality (AR) and Virtual Reality (VR) have been applied to many applications such as education, tourism, advertising, and news reports. With the rapid development of VR and AR technology, there are higher continuously requirements for enhancing brochure media effectiveness. AR and VR provide a potential solution for interaction between person and brochure as new emerging information technology. In this research, AR and VR are used to better educate tourists and visitors about the museum they choose to visit. Muhammadiyah Museum and its historical collection used as an example of applying AR and VR to the brochure as a promoting media. The Multimedia Development Life Cycle (MDLC) method applied to develop AR and VR. AR and VR system was tested by 30 under graduation students with 74.92% of acceptance. This research shows the AR and VR brochure is very feasible successfully sent information about the various kinds of historical collections in museum Muhammadiyah and very helpful as promoting media.
DYNAMIC CHARACTERIZATION OF BALL BEARING IN TURBINE PROPELLER USING BUMP TEST METHOD
Authors: Pratiwi Monika Audiya , Ikhsan Muhammad , Octavianto Rio Duzan , Hamid Abdul , Subekti Subekti
Published: March 2021

Bearing is an essential component in a mechanical rotating equipment system. It is no less important than lubrication to prevent wear is very important to consider in the mechanical maintenance system of rotating equipment. Bearing wear is one of the problems in wind turbines that will increase maintenance costs, shorten the wind turbines' lifespan, and cause the component or overall damage to the wind turbine. The latest technology has provided instruments for analyzing the damage of elements in a bearing according to the caused vibrations. Therefore, this study was performed on Ball Bearing Turbine Propeller to identify the dynamic characteristics of Ball Bearing with and without lubrication. The test was carried out using the Bump Test method applied in three measured parts: X, Y, and Z axes. The measuring instrument which was used was Fast Fourier Transform (FFT) Analyzer (Ono Sokki) and the data were analyzed using MATLAB. It was identified that the application of oil could reduce the amplitude and decrease the frequency. Personal frequency appearing more than once indicates the existence of global vibration modes. The frequency which only appears once in the measurement spot indicates local vibration modes. The highest frequency both after and before the application of oil was found in the Y-axis.
SELF-COLLISION AVOIDANCE OF ARM ROBOT USING GENERATIVE ADVERSARIAL NETWORK AND PARTICLES SWARM OPTIMIZATION (GAN-PSO)
Authors: Iklima Zendi , Adriansyah Andi , Hitimana Sabin
Published: March 2021

Collision avoidance of Arm Robot is designed for the robot to collide objects, colliding environment, and colliding its body. Self-collision avoidance was successfully trained using Generative Adversarial Networks (GANs) and Particle Swarm Optimization (PSO). The Inverse Kinematics (IK) with 96K motion data was extracted as the dataset to train data distribution of  3.6K samples and 7.2K samples. The proposed method GANs-PSO can solve the common GAN problem such as Mode Collapse or Helvetica Scenario that occurs when the generator  always gets the same output point which mapped to different input  values. The discriminator  produces the random samples' data distribution in which present the real data distribution (generated by Inverse Kinematic analysis).  The PSO was successfully reduced the number of training epochs of the generator  only with 5000 iterations. The result of our proposed method (GANs-PSO) with 50 particles was 5000 training epochs executed in 0.028ms per single prediction and 0.027474% Generator Mean Square Error (GMSE).
BANDWIDTH AND GAIN ENHANCEMENT OF MICROSTRIP ANTENNA USING DEFECTED GROUND STRUCTURE AND HORIZONTAL PATCH GAP
Authors: Rusdiyanto Dian , Apriono Catur , Astuti Dian Widi , Muslim Muslim
Published: March 2021

This research proposed microstrip antenna design using the Defected Ground Structure (DGS) and horizontal patch gap (HPG) for bandwidth and enhancement purposes. This design is to reduce the weakness of a microstrip antenna, which has small gain and narrow bandwidth. The design was simulated in CST Microwave Studio with a working frequency of 2.4 GHz. The design consists of three stages model, i.e., conventional design, DGS modification, and the combination DGS using a Horizontal Patch Gap (DGSHPG). The radius of the conventional circular patch is 16.7 mm. The substrate has 4.6 of dielectric constant, 1.6 of substrate height, and 0.025 of the loss tangent. The simulation results show that the DGS design produces more bandwidth and gain than a conventional design, where the bandwidth and gain improvement are 421.2 MHz and 1.73 dB, respectively. The DGS model is combined with a gap that separates the circular patch (DGSHPG) to achieve the optimum design. The results show the bandwidth and gain improvement of more than 50% and 18.1% compared to the DGS design, respectively. Other parameter performance also shows improvement, such as a reflection factor with -53.3 dB at the center frequency. The physical change also influences the patch’s radius, where it is reduced around 1.4 mm or 8.4% from the original design. Overall, the proposed design has succeeded in achieving bandwidth and gain enhancement and reducing the patch dimension.