bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison Between Standard Vs. High Dosing Venous Thromboembolism (VTE) Prophylaxis in COVID19 Critically Ill Patients: A Multicenter, Observational Study
Authors: Aljuhani Ohoud , Alsulaiman Khalid , Hafiz Awattif , Eljaaly Khalid , Alharbi Aisha , Algarni Rahma , Homaid Sarah Al , Qahtani Khawla Al , Alsulaiman Tareq , Vishwakarma Ramesh , Ghamdi Ghassan Al , Alalawi Mai
Published: May 2021

Background: There is uncertainty about the appropriate dosing regimen, safety, bleeding risk, and the predisposing factors for thrombosis/bleeding risk in critically ill COVID-19 patients. Also, the available evidence is limited and depends either on observational studies or randomized trials with small sample size. Thus, the aim of the study is to determine the optimal dosing of pharmacological VTE prophylaxis in critically ill patients with COVID-19 patients.Methods: A multicenter, retrospective, cohort study conducted at two governmental tertiary hospitals in Saudi Arabia. All critically ill COVID 19 patients who received pharmacological VTE prophylaxis and were admitted to Intensive Care Units (ICUs) between March 1st, 2020 to January 31st, 2021 were included. Patients who received Standard dosing VTE prophylaxis were compared to patients who received high dosing pharmacological VTE prophylaxis.Results: A total of 758 patients were screened; 565 patients were included in the study. We matched 352 patients using propensity score matching (1:1) according to the baseline severity scores (i.e., APACHE II score, SOFA score), history of CKD, and AKI within 24 hours of ICU admission. The differences in venous thromboembolism (OR (95%CI): 0.75 (0.16–3.38), p-value = 0.70) and any case of thrombosis (OR (95%CI): 1.22 (0.52–2.86), p-value = 0.64) were not statistically significant between the two groups. In contrast, minor bleeding was associated with the use of high dosing regimen of VTE prophylaxis (OR (95%CI): 3.39 (1.08–10.61), p-value = 0.04). There was no difference in the 30-day ICU mortality nor in-hospital mortality between the two groups (OR (95%CI): 1.26 (0.77–2.05), p-value = 0.36 and OR (95%CI): 1.05 (0.66–1.68), p-value = 0.83 respectively).Conclusion: High dosing pharmacological VTE prophylaxis in critically ill COVID-19 patients was not associated with VTE, thrombosis, or mortality benefits but led to an increased risk of minor bleeding. Further randomized clinical and interventional studies are required to confirm our findings.
Personalized repetitive transcranial magnetic stimulation for primary progressive aphasia
Authors: Pytel Vanesa , Cabrera-Martín María Nieves , Delgado-Álvarez Alfonso , Ayala José Luis , Balugo Paloma , Delgado-Alonso Cristina , Yus Miguel , Carreras María Teresa , Carreras José Luis , Matías-Guiu Jorge , Matias-Guiu JA
Published: May 2021

BackgroundPrimary progressive aphasia (PPA) is a neurodegenerative syndrome for which no effective treatment is available. We aimed to assess the effect of repetitive transcranial magnetic stimulation (rTMS), using personalized targeting.MethodsWe conducted a randomized, double-blind, pilot study of patients with PPA receiving rTMS, with a subgroup of patients receiving active- versus control-site rTMS in a cross-over design. The primary outcome was changes in spontaneous speech (word count). Secondary outcomes included changes in other language tasks, global cognition, global impression of change, neuropsychiatric symptoms, and brain metabolism using FDG-PET.ResultsTwenty patients with PPA were enrolled (14 with nonfluent and 6 with semantic variant PPA). Compared to the control group, the group receiving active-site rTMS showed improvements in spontaneous speech, other language tasks, patient and caregiver global impression of change, apathy, and depression. This group also showed improvement or stabilization of results obtained in the baseline examination. Increased metabolism was observed in several brain regions after the therapy, particularly in the left frontal and parieto-temporal lobes and in the precuneus and posterior cingulate bilaterally.ConclusionsWe found an improvement in language, patient and caregiver perception of change, apathy, and depression using high frequency rTMS. The increase of regional brain metabolism suggests enhancement of synaptic activity with the treatment.Trial registrationNCT03580954 (clinicaltrials.gov). Registered 10 July 2018 (retrospectively registered).URL of the trial registry recordhttps://clinicaltrials.gov/ct2/show/NCT03580954
Bayesian Networks and Causal Inference for the Interpretation of Patients' Symptom Experience
Authors: Papachristou Nikolaos , Barnaghi Payam , Allison Sarah J. , Kober Kord M. , Miaskowski Christine
Published: May 2021

Given that oncology patients experience an average of 14 co-occurring symptoms, the identification of sentinel or core symptoms is a critical need for effective symptom management. However, this task is an extremely challenging one. To address this need, we used Bayesian Network Analysis (BNA) approaches on a comprehensive dataset of 38 distinct and co-occurring cancer symptoms from a sample of 1328 cancer patients receiving chemotherapy. We evaluate three classes of algorithms (constrained-based, score-based, hybrid algorithms) on their structural stability and performance with different sample sizes and demographic characteristics (gender and age). We demonstrate their potential clinical use for casual discovery and inference. The hybrid algorithm identified more dense network structures that were clinically relevant, not only for the entire sample but for our case studies of gender and age. Our work demonstrates how to process a comprehensive set of symptom experience data for interactions and provides valuable information on the use of BNA in clinical practice when different algorithms, sample sizes and comparative sub-groups are evaluated.
Heterogeneous Catalytic Oxidation of 5-hydroxymethylfurfural (5-HMF) To 2,5-Diformoylfuran (DFF) Using Fe3O4@C Catalyst
Authors: Ranganath Kalluri V.S , Jaiswal Rama
Published: May 2021

The selective oxidation of 5-hydroxymethyl furfural (HMF) to 2,5-diformylfuran (DFF) is one of the rapidly growing research area due to having its own importance in the fuel technology. We report a new heterogeneous catalyst for the oxidation of HMF to DFF in aqeous medium using a carbon soot deposited on magnetite (Fe3O4@C). Further, the potentiality of our catalyst has also been realized in direct production of DFF from biomass (using either fructose or glucose) with high conversions via two consecutive steps.
Comparison of 10 emerging SARS-CoV-2 Variants: infectivity, animal tropism, and antibody neutralization
Authors: Zhang Li , Cui Zhimin , Li Qianqian , Yu Yuanling , Wu Jiajing , Nie Jianhui , Ding Ruxia , Wang Haixin , Zhang Yue , Liu Shuo , Chen Zhihai , He Yaqing , Xu Wenbo , Huang Weijin , Wang Youchun
Published: May 2021

Ten emerging SARS-CoV-2 variants—B.1.1.298, B.1.1.7, B.1.351, P.1, P.2, B.1.429, B.1.525, B.1.526-1, B.1.526-2, B.1.1.318—and seven corresponding single amino acid mutations in the receptor-binding domain were examined using SARS-CoV-2 pseudovirus. The results indicate that the current SARS-CoV-2 variants do not increase infectivity among humans. The K417N/T, N501Y, or E484K-carrying variants exhibited increased abilities to infect to mouse ACE2-overexpressing cells. The activities of Furin, TMPRSS2, and cathepsin L were increased against most of the variants. RBD amino acid mutations comprising K417T/N, L452R, Y453F, S477N, E484K, and N501Y caused significant immune escape from 11 of 13 monoclonal antibodies. However, the resistance to neutralization by convalescent serum or vaccines was mainly caused by the E484K mutation, while the neutralization of E484K-carrying variants was decreased by 1.1–6.2-fold. The convalescent serum from B.1.1.7- and B.1.351-infected patients neutralized the variants themselves better than other SARS-CoV-2 variants.
Continuing use of aspirin in total knee arthroplasty: safe or not?
Authors: Li Zeng , Xiang Shuai , Du Yan , Bian Yanyan , Feng Bin , Weng Xisheng
Published: May 2021

Background: There are a growing number of patients who take aspirin routinely before TKA to prevent vascular events. However, it may increase the risk of bleeding and wound complications. It remains controversial regarding the safety of continuing use of aspirin during the perioperative period of TKA. Methods: The present study retrospectively selected TKA cases from the Joint Arthroplasty Database at the Peking Union Medical College Hospital from January 2014 to December 2019. The comparisons between the aspirin group and non-aspirin group on the aspects of bleeding parameters (blood loss, transfusion rate, drainage volume, hemoglobin and hematocrit change) and complications (cardiac events, venous thromboembolism events, cerebrovascular events and wound events) were performed. Results: A total of 560 patients with unilateral TKA and 285 patients with bilateral TKA were extracted. Among those, 280 patients used aspirin preoperatively. No differences were found in demographic and surgical characteristics between the aspirin and non-aspirin group except for the proportion of coronary artery diseases (p<0.05). For the outcomes, there were no significant higher blood loss in the surgery and transfusion rate during or after the surgery in the aspirin group, while the drainage in the aspirin group was higher than control group, especially for bilateral TKAs (p=0.043). And the hemoglobin and hematocrit in POD5 in aspirin group were significant lower in both unilateral and bilateral TKAs. For complications, though there were lower vascular related complication rate in aspirin group after unilateral TKAs (p=0.040), the wound event rate in aspirin group were higher than the control group (p=0.049). Conclusion: Continuing use of aspirin could prevent vascular related complications during the perioperative period of TKA. However, it might also increase the risk of bleeding and wound complications which we should pay attention to.
The Effect of Serum Protein on Enterococcus Faecalis Adhesion to Three types of Root Sealers and Gutta-Percha
Authors: Lin Xinwei , Chi Danlu , Gong Qimei , Tong Zhongchun
Published: May 2021

The aim of this study was to evaluate the effect of serum protein on Enterococcus faecalis adhesion and survival on the surface of Apexit Plus (AP), AH-Plus (AH), a tricalcium silicate–containing sealer (Iroot SP) and gutta-percha (GP). AP, AH or Iroot SP was evenly coated on GP. After root sealers setting, the amount of E. faecalis adhering to the sealers was evaluated in fetal bovine serum (FBS) or TSBG medium by viable cell plate counts. The morphology of the sealers coated on GP and 7-day-old E. faecalis biofilm was observed by scanning electron microscopy (SEM). Furthermore, the ratios of viable and dead cells in biofilm were calculated by a Carl Zeiss confocal laser scanning microscope (CLSM) and ZEN software. In 1 and 7 days of assays, the amount of E. faecalis adhering to the surface of sealers or GP in FBS was significantly less than in TSBG (P < .05). FBS more significantly reduced the bacterial amount on the SP and GP than on the AP and AH. E. faecalis biofilm on the AP and SP were more typical in the TSBG than in the FBS. The ratio of viable cell in the E. faecalis biofilm was the lowest on the SP by CLSM. It can be stated that Apexit Plus, AH-Plus and Iroot SP sealers may provide the substrate for E. faecalis adhesion, and the serum proteins significantly influenced bacterial adhesion to the surface of Apexit Plus, AH-Plus, Iroot SP and gutta-percha.
Macrophages in tumor-associated adipose microenvironment accelerate tumor progression
Authors: Li Bei , Wu Qi , Yang Qian , Li Zhiyu , Li Juanjuan , Wu Juan , Zhu Shan , Wang Lijun , Liao Shichong , Sun Si , Xu Zhiliang , Sun Shengrong
Published: May 2021

Background: Macrophages particularly contribute to the progression of obesity-related tumor. However, the mechanisms that the tumor-adipocyte crosstalk may enable the properties and plasticity of macrophages remain still unclear.Methods: Survival probabilities for recurrence-free survival (RFS) were estimated by the Kaplan–Meier method based on immunohistochemistry and immunofluorescence images. 3T3-L1 cells were co-cultivated with 4T1 and MDA-MB-231 cells. Then the co-cultivated media were used to treat THP-1/RAW264.7 cells. The markers of macrophages were detected by immunofluorescence and Western blot. Transwell migration assay, was conducted to determine the migration capability of macrophages. RT-PCR and ELISA were used to detect the expression and secretion level of chemokines, respectively. Immunofluorescence imaging and Western blot were used to investigate the role of SOCS6/STAT3 signaling pathway in the polarization of macrophages. microRNA mimic and inhibitor, and xenograft models were used to explore the role of miR-155 in the polarization of macrophages.Results: We demonstrate that CD163-positive macrophages aggregated to surround adipocytes in breast cancer tissues, which was associated with tumor relapse. In tumor-adipocyte microenvironment, CD163-positive macrophages are recruited and polarized via the elevated expression of CCL2 and CCL5. Consistently, the eliminated macrophages partially inhibited adipocytes-induced tumor proliferation. Likewise, inhibiting chemokines and their receptors or suppressing the phosphorylation of STAT3 significantly decreased tumor burden in vivo. Finally, the source of CCL2 and CCL5 mainly derived from adipocytes. In coculture of tumor cells and adipocytes, the level of exosomal miRNA-155 was high, then it promoted the generation and release of CCL2 and CCL5 from adipocytes through targeting SOCS6/STAT3 pathway. Inhibition of exosomal miRNA-155 in tumor cells reduced the CCL2 and CCL5 levels in tumor-adipocytes coculture, and further retarded tumor growth.Conclusion: These results suggest a novel target of tumor-adipocyte-macrophage interconnect that could facilitate obesity-induced tumor progression.
Digital learning: eine neue didaktische Normalität. Erfahrungen mit der digitalen Lehre unter Covid-19 Pandemie-Bedingungen
Authors: Ries Thorsten
Published: May 2021

In der außerordentlichen Pandemie-Situation wurden wertvolle Erfahrungen mit Vollzeit-Online-Lehre gesammelt, welche der strategischen, online-didaktischen und technischen Weiterentwicklung und dem sinnvollen Ausbau von Blended Learning und digitaler Lehre an den Universitäten in der Zeit nach der Covid-19 Pandemie dienen können. Die auf breiter Basis gewonnene praktische und konzeptuelle Kompetenz im Bereich digitaler Lehre bei Lehrenden und Studierenden ist als eine Zukunftsressource zu betrachten. In Verbindung mit der zunehmenden Verbreitung von Digital Humanities sind die Voraussetzungen für die Herausbildung einer neuen didaktischen Normalität gegeben. Der vorliegende Beitrag basiert auf Erfahrungen mit der digitalen Lehre an der Universität Regensburg im Sommersemester 2020, einer Umfrage unter Studierenden zur digitalen Lehre im Frühjahrs-Semester am Dept. of Germanic Studies an der University of Texas at Austin, USA, und Beobachtungen und Gesprächen mit Studierenden und Lehrenden an der Universität Gent, Belgien. Die Bemerkungen versuchen, aus diesen ersten Erfahrungen ausgewogenere und für die Entwicklung der digitalen Didaktik produktive Perspektiven zu gewinnen und greifen der systematischen Auswertung der derzeit noch laufenden Umfragen und Studien mit breiterer Datenbasis nicht vor.
Hydration-driven stabilization and volume collapse of grain boundaries in Mg2SiO4 forsterite predicted by first-principles simulations
Authors: Ghosh Dipta B. , Karki Bijaya B. , Wang Jianwei
Published: May 2021

Grain boundaries in mantle minerals are of critical importance to geophysical and geochemical processes of the Earth’s interior. One of the fundamental issues is to understand how the water (H2O) component influences the properties of grain boundaries in silicate materials. Here, we report the results of the structure and stability of several tilt grain boundaries in Mg2SiO4 forsterite over the pressure range 0 to 15 GPa using density functional theory-based first-principles simulations. The results suggest greater energetic stability and hydration-driven volume collapse (negative excess volume) at zero pressure for the majority of hydrous grain boundaries relative to the anhydrous (dry) ones. All the hydrous grain boundaries become increasingly favorable at elevated pressures as the calculated hydration enthalpy systematically decreases with increasing pressure. The hydrous components at the interfacial regions are predominantly in the hydroxyl form and, to a lesser extent, in the molecular H2O form. Their calculated ratio ranges from 1.6 to 8.7 among the different grain boundary configurations. Our structural analysis also reveals that the hydroxyls are bound to either both Mg and Si or to Mg only. In comparison, the molecular species are bound only to Mg sites. Besides direct oxygen-hydrogen bonding, intermolecular hydrogen bonding becomes important with compression. On the basis of our results, we suggest that local atomic rearrangements caused by dissociative adsorption of water facilitate efficient compaction of the boundary interfaces, which, in turn, results in greater relative stability of hydrous grain boundaries. This means that water prefers to be incorporated within the grain boundaries over the bulk of silicate materials.
A high-pressure, clinopyroxene-structured polymorph of albite in highly shocked terrestrial and meteoritic rocks
Authors: Ma Chi , Tschauner Oliver , Kong Mihye , Beckett John R. , Greenberg Eran , Prakapenka Vitali B. , Lee Yongjae
Published: May 2021

Clinopyroxenes with excess Si have been described in run products from high-pressure experiments and inferred to have existed in nature from retrograde transformation phases. Here, we present the discovery of albitic jadeite, (Na,Ca,☐1/4)(Al,Si)Si2O6—the first natural, sodic clinopyroxene with excess Si occupying the octahedral cation site, M1, and a corresponding ¼ vacancy on the M2-site in the Ries impact structure and in a suite of L6 ordinary chondrites, EET 13014, EET 13052, NWA 1662, and TIL 08001. Garnet compositions in these samples indicate shock pressures of 18–22 GPa. Based on our survey, albitic jadeite is likely to be rather common in terrestrial and meteoritic shock-metamorphic environments. Shock-generated jadeite should be reexamined with respect to excess Si.
Analytical Investigation of Active Compound Contents of Panax ginseng C.A. Meyer and Ginkgo biloba L. Supplements Fortified with Apitherapy Products
Authors: AKYILDIZ İsmail Emir , RADAY Sinem , ERDEM Özge , ACAR Sezer , COŞKUN İlknur , DAMARLI Emel
Published: May 2021

Extracts of therapeutic plants of nature, such as Ginkgo biloba L. and Panax ginseng C.A. Meyer (P.ginseng) are highly requested. Recently admixtures of these extracts with apitherapy products are also available. In this study, as research materials, P.ginseng, and Ginkgo biloba L. supplements in the form of tablets, paste, and liquid extracts prepared as a mixture with bee products were compared in terms of their ginsenosides, phenolics, terpene lactones, and antioxidant capacities. Within this study, it was aimed to clarify the active ingredients P.ginseng extracts, Ginkgo biloba L. extracts, and their mixtures with bee products by developing advanced and novel analytical methods. Additionally, it was purposed to unveil the contribution of bee products to phytotherapy supplements of P.ginseng and Ginkgo biloba L. on the basis of secondary metabolites. Ultrasound-assisted hydroalcoholic extraction was applied at sample preparation and supernatants were analyzed at UPLC-MS/MS and UV-Visible spectrophotometer. The antioxidant activities were determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. As a result, total ginsenoside contents of the products per serving were ranged between 9.7 mg to 150.2 mg. Terpene lactones of the ginkgo products were ranged between 0.1 mg to 9.5 mg per serving. The antioxidant activities of all products were determined between 13% and 92%. Quercetin, rutin hydrate, CAPE, kaempferol, galangin, chrysin, gallic acid, pinocembrin, and isorhamnetin were found as the predominant phenolics. Due to their higher antioxidant capacities, superior phenolic concentrations, and diversities, it was enlightened that apitherapy products can augment the phytotherapy efficacies of P.ginseng and Ginkgo biloba L. supplements.
On-shell effective theory for higher-spin dark matter
Authors: Falkowski Adam , Isabella Giulia , Machado Camila
Published: May 2021

We apply the on-shell amplitude techniques in the domain of dark matter. Without evoking fields and Lagrangians, an effective theory for a massive spin-S particle is defined in terms of on-shell amplitudes, which are written down using the massive spinor formalism. This procedure greatly simplifies the study of theories with a higher-spin dark matter particle. In particular, it provides an efficient way to calculate the rates of processes controlling dark matter production, and offers better physical insight into how different processes depend on the relevant scales in the theory. We demonstrate the applicability of these methods by exploring two scenarios where higher-spin DM is produced via the freeze-in mechanism. One scenario is minimal, involving only universal gravitational interactions, and is compatible with dark matter masses in a very broad range from sub-TeV to the GUT scale. The other scenario involves direct coupling of higher-spin DM to the Standard Model via the Higgs intermediary, and leads to a rich phenomenology, including dark matter decay signatures.
DIFFERENTIAL DIAGNOSIS OF BRAIN GLIOMAS: THE POSSIBILITIES OF DYNAMIC PET-CT WITH 18F-FLUORODEOXYGLUCOSE
Authors:   N.N. Burdenko National Medical Research Center of Neurosurgery, Postnov A.A. , Konakova T.A. ,   N.N. Burdenko National Medical Research Center of Neurosurgery, Kalaeva D.V. ,   N.N. Burdenko National Medical Research Center of Neurosurgery, Batalov A.I. ,   N.N. Burdenko National Medical Research Center of Neurosurgery, Vikhrova N.B. ,   N.N. Burdenko National Medical Research Center of Neurosurgery, Pronin I.N. ,   N.N. Burdenko National Medical Research Center of Neurosurgery
Published: May 2021

Purpose. The aim of this prospective study, which included the analysis of data from 52 patients with primary brain gliomas, was to look for additional PET-CT biomarkers determined on the basis of the analysis of the first minute of dynamic PET scanning in order to increase the specificity and sensitivity of differential diagnosis of gliomas. 18F-FDG was administered simultaneously with the data collection began. Materials and methods. The study group included data of 52 patients, 27 men, 25 women, age 18-80 years, median 48 years + 12. Histologically, these were glioblastomas (n= 19), anaplastic astrocytomas (n=9), anaplastic oligodendrogliomas (n= 6), benign oligodendrogliomas (n= 6), and diffuse astrocytomas (n=9). Each patient underwent a standard brain MR- study (T2, T2-FLAIR, T1, 3D T1 with contrast enhancement). The selected patients then underwent PET-CT examination (Siemens Truepoint scanner, Siemens Medical Solutions, USA) with radiopharmaceutical 18F-FDG according to the dynamic protocol developed in the our department. Data collection started simultaneously with intravenous administration of radiotracer for the next 40 minutes. 34 frames of 6X10 sec, 6x20 sec, 6x30 sec, 4x60 sec and 12x150 sec were reconstructed. Results. Among the proposed new PET parameters, T/N60s (accumulation index averaged over the first 60 seconds after the administration of 18 F-FDG) turned out to be the most successful, which made it possible to statistically reliably separate glioblastomas from all other histological subtypes of gliomas. Thus, for glioblastomas, T/N60s = 1.6 ± 0.4, and for anaplastic oligodendrogliomas, it was 1.1 ± 0.2, p<0.01. Moreover, T/N60s made it possible to reliably differentiate not only Gr. II from gliomas Gr.III + Gr.IV, but also to differentiate glioblastomas from anaplastic astrocytomas (p<0.01) and glioblastomas from anaplastic and benign oligodendrogliomas (p<0.05 and p<0.01, respectively). All types of gliomas had an T/N60s>1.0, while its final accumulation could be lower than in intact tissue. A possible reason for this phenomenon may be tumor neoangiogenesis, which develops even in the case of low-grade gliomas. Conclusion. The use of the proposed technique for studying patients with brain gliomas and analyzing the data obtained with the new PET biomarkers significantly improves the quality of differential diagnosis of gliomas using 18F-FDG. It also allows reducing the study time for one patient without losing the specificity and sensitivity of diagnosis.
Sustainability of polymer composites and its critical role in revolutionising wind power for green future
Authors: P. Subadra Sharath , Griskevicius Paulius
Published: May 2021

Fibre reinforced polymer composites are gaining wide acceptability in different sectors due their high specific mechanical properties. They have effectively replaced conventional material like metals in many applications thus imparting lighter weight with higher efficiency. Wind energy sector has grown tremendously over the last decade and as per “The Global Wind Turbine Market-Forecasts from 2020 to 2025”, global wind turbine market was valued at US$ 90.144 billion in 2019 and is expected to grow at a CAGR of 5.34 % to reach an estimated market size of US$123.154 billion by 2025. Wind turbine blades are fabricated using fibre reinforced composites with ideally a balsa or foam core. The composites used in this case are essentially glass reinforced in epoxy resins, and these highly engineered materials are difficult to recycle as epoxy is a thermoset resin and are not re-mouldable. This poses an environmental problem and a loss in terms of recoverable capital. Thermoplastics as against thermosets could be an alternative resin material for the blades but this has been less explored by the wind sector. The use of thermoplastic could impart cost reductions due to shorter manufacturing cycle times, recovery of raw materials and reduced tooling adjustments in terms of heating. Recovery of composite constituent parts can provide economic benefits because those constituent parts have high embedded energy. In the context of this dilemma of recyclability of wind turbine blades, this review paper intent to explore the current research and future prospect of recycling wind turbine blade materials.
La mirada regional
Authors: Ochoa-Jaramillo Francisco Luis
Published: May 2021

La reciente clasificación de Publindex ha dejado por fuera a CES Medicina. Aunque la Revista cumplió todos los requisitos de calidad metodológica y editorial, no se logró obtener el puntaje mínimo en el Índice H5 para su clasificación. Pero la lista de sitios en donde está registrada o indexada la Revista es amplia -cerca de 30- y es clara evidencia de que nuestro trabajo, la calidad editorial, las temáticas publicadas y el rigor metodológico cumplen los estándares para ser aceptados en ellos.
The demographic dynamics of youth cohorts of St. Petersburg during the period of educational migrations
Authors:   North-West Institute of Management, The Russian Presidential Academy of National Economy and Public Administration (The Presidential Academy, RANEPA), Delva Kirill I.
Published: May 2021

One of the key sources of the population of cities in the world and Russia is population migration with subsequent “fixation” in a big city for permanent residence. However, the question of the distribution of young generations after the completion of education within cities has been studied rather poorly, especially in the Russian-language literature. This situation is due to the infrequent appearance of socio-demographic statistics for such a study at the intraregional level. This paper seeks to fill this gap; it considers the intra-urban dynamics of a number of youth cohorts born in 1986–1995 in St. Petersburg for the period of 2002–2015. The article determines the amount of inflow of the studied youth cohorts into the city and city districts during the period mentioned above. It was revealed that during the period of educational migrations, the districts of the city experience a different increase in the number of youth cohorts; however, the territorial structure of the growth of young people in both studied generations remains stable. Also, the paper proposes a typology of city districts by the size of the inflow of a group of youth cohorts to the city districts and the real estate market, expressed in the cost of housing in the districts and in terms of housing commissioning. An attempt to explain the reasons for the differences in the growth of youth cohorts born in 1986–1990 in the districts of the city showed that the increase is associated with the introduction of new housing and does not have a direct relationship with prices in the real estate market.
A hospitalidade de Pelotas/RS pela visão de quem não enxerga e aos passos de quem não caminha
Authors: Moraes Rodrigues Igor , Marroni Minasi Sarah , Islabão Lopes Alice , Souza da Silva Luziara
Published: May 2021

O objetivo proposto desta pesquisa é analisar a hospitalidade da cidade de Pelotas/RS na percepção das pessoas com deficiência visual e física (cadeirantes). Metodologicamente, esta pesquisa caracteriza-se por ser de natureza exploratória e descritiva, realizada por meio de pesquisa bibliográfica com abordagem qualitativa em que foram aplicados questionários com os sujeitos da pesquisa por e-mails e redes sociais Facebook e Whatsapp. Como principais resultados encontrados, identificou-se que o entendimento sobre hospitalidade de todos os sujeitos está relacionado ao bem receber-acolher. Para as pessoas com deficiência visual a questão do respeito com o visitante prevalece enquanto os sujeitos cadeirantes acrescentam a relação com a acessibilidade. No que tange à concepção de hospitalidade urbana e cidade hospitaleira, apesar das dimensões em comum, as falas das pessoas com deficiência visual estão mais relacionadas à identificação e envolvimento ativo do ser humano na cidade, enquanto as pessoas cadeirantes trazem à tona dimensões de acessibilidade física. Já no que diz respeito a Pelotas ser uma cidade hospitaleira, os sujeitos cadeirantes divergem sobre esta concepção apontando a (falta de) acessibilidade física como principal motivo enquanto todos os sujeitos com deficiência visual consideram Pelotas hospitaleira. Com os resultados desta pesquisa foram sistematizadas dimensões da cidade hospitaleira para pessoas com deficiências além de fomentar reflexões sobre hospitalidade e pessoas com distintos tipos de deficiência.

Palavras-chave: Turismo. Hospitalidade Urbana. Deficiência Visual. Cadeirantes. Pelotas/RS.
Personalidade da marca de destinos, fontes de informações e sua relação com o critério de escolha da chapada das mesas por parte dos turistas
Authors: Costa Junior Lindemberg , Christynne De Souza Sampaio Evellyn
Published: May 2021

Este estudo tem como objetivo identificar o critério de escolha de turistas ao decidir pela Chapada das Mesas, bem como perceber a relação entre o critério de escolha dos turistas e a personalidade da marca de destinos; verificar os traços que constituem a personalidade da marca de destinos na visão de turistas; e identificar o grau de relevância de diferentes fontes de informações utilizadas por turistas na busca por um destino turístico. A Chapada das Mesas está localizada no Estado do Maranhão, havendo a cidade de Carolina como base para explorar as belezas da região. Adotou-se metodologia quantitativa, com caráter descritivo e corte transversal. Neste contexto, optou-se pela coleta primária de dados utilizando o formulário eletrônico Google Forms. Os resultados sugerem que a Chapada das Mesas é um local excitante, muito por conta da beleza do local. Para buscar maiores informações sobre o local de destino, os turistas procuram a opinião de amigos e familiares e também de pessoas confiáveis que já visitaram o local. Revela-se ainda que a internet é um importante canal de informação, pois pode-se ver as fotos e comentários de turistas com experiência previa do local.

Palavras-chave: Marketing Turístico. Personalidade da Marca. Consumidor de Turismo.
PENTINGNYA TES KEMAHIRAN BERBAHASA INDONESIA BAGI PEMELAJAR BIPA BERTUJUAN AKADEMIK
Authors: Kusmiatun, M.Hum. Ari
Published: May 2021

Penelitian ini bertujuan untuk mendeskripsikan kebutuhan pemelajar asing dalam program BIPA akademik terhadap tes kemahiran berbahasa Indonesia akademik. Penelitian ini merupakan tahap awal dari penelitian pegembangan tes kemahiran berbahasa Indonesia yang diperuntukkan bagi pemelajar BIPA bertujuan akademik. Jenis penelitian dalam tahap awal atau studi pendahuluan ini adalah penelitian kualitatif. Penelitian ini mendeskripsikan beberapa hal terkait kebutuhan tes kemahiran bagi pemelajar asing bertujuan akademik. Pengumpulan data dilakukan dengan menggunakan teknik observasi, dokumentasi, angket, dan wawancara. Subjek penelitiannya adalah pemelajar asing, dosen pengajar yang di kelasnya terdapat  mahasiswa asing, dan pengelola program BIPA bertujuan akademik. Teknik analisis data yang digunakan adalah kualitatif. Keabsahan data dalam penelitian ini menggunakan trianggulasi data, berupa tianggulasi sumber dan metode. Hasil penelitian menunjukkan bahwa kebutuhan tes kemahiran berbahasa Indonesia diperlukan oleh para pemelajar asing yang bertujuan akademik. Dengan tes ini, kemampuan berbahasa Indonesia mereka dapat terdeteksi dan disikapi sehingga mereka dapat menjalani perkuliahan dengan baik dan lancar.Kata Kunci: tes kemahiran berbahasa Indonesia, pemelajar asing, bertujuan akademik
PENINGKATAN KOMPETENSI TATA BAHASA PRANCIS MAHASISWA JURUSAN PENDIDIKAN BAHASA PRANCIS FBS UNY DENGAN MODEL PEMBELAJARAN INQUIRY
Authors: Wilujeng Nuning Catur Sri , Sumiyati Siti , T. A. Anggraini Dora , Dwiyuliani Titis
Published: May 2021

(Title: Improving French Grammar Competence of The Students at French Departement, Faculty of Languages and The Arts, Yogyakarta State Uninersity Through The Inquiry Model). This research aimed to improve the students’ French grammar competence through the Inquiry model with seven steps, ie : developing a question, generating a hypothesis, developing an experimental desain, collecting and recording data, analizing data, reaching conclusions, forming and  extending generalizations, communicating results. This research was a class room action reseach study conducted  in two cycles from the 2th to 27th May 2016. The research subjects were 21 students atten­ding in Grammaire 4 in classes E and J at the French Departement, Faculty of Languages and the Arts, Yogyakarta State University. The data were collected through observations, field notes, and achievement test. They were analized using qualicative and quantitative descriptive techniques. The results of the study showed that the application of the inquiry model was capable of improving the students’s French grammar learning, both in the process and the product. The success in the process was indicated by student’s activeness in the learning activities for the Grammaire 4 through the inquiry model, and the average attainment in the first cycle was 70.47% and 77.1% in second cycle. The success in product was indicated by improvement of the students’French grammar competence, reflected by the  improvement of average score of post-test. The difference between the  average  score of pre-test and post-test scores was significant because the result of the paired sample t-test both in the first cycle and second one was p (0.001) 0.05. Keywords: inquiry model, French grammar, action research
THE EFFECT OF TELEVISION PROGRAM ON CHILDREN’S FOREIGN LANGUAGE ACQUISITION
Authors: Rajulain Muhammad
Published: May 2021

(Title: The Effect of Television Program on Children’s Foreign Language Acquisition). Since it was first discovered in the 1920s, television has become an integral part of modern human life. The influence of television programs or programs on children's foreign language acquisition has become an interesting research subject to study. This study aims to determine the effect of television programs on the acquisition of foreign languages in a subject aged two years and three months using a qualitative method where the researcher also acts as an observer. The data obtained is recorded in the form of a diary, and interviews are conducted with parents and the people closest to the subject to obtain accurate data. The results of the study showed that the television programs being watched did not have a significant effect on the acquisition of foreign languages on the subjects studied. Keywords: Television programs, foreign language acquisition, children
PENYUSUNAN BAHAN AJAR DENGAN PENGINTEGRASIAN KOMPETENSI LISTENING DAN SPEAKING BAGI MAHASISWA PBI
Authors: Nurhayati Lusi , Diyanti B. Yuniar , Kurniasih Siwi Karmadi
Published: May 2021

(Title: Development of Teaching Materials By Integrating Listening and Speaking Competency For PBI Students). This study aims to produce teaching material models by integrating listening and speaking competencies. This research is a type of research and development (Research and Development). The research subjects were 5th semester students who had taken the Listening for Academic Purposes and Speaking for Academic Purposes courses. The integration of learning material in the Listening for Academic Purposes (LAP) and Speaking for Academic Purposes (SAP) courses for PBI students in semester 4 is very necessary. The steps that have been carried out in this study have reached the stage of needs analysis and have succeeded in identifying several important things needed in developing teaching materials such as types of texts, activities needed and liked by students, types of media that can be used, reaction patterns and assessments . The learning material in the LAP course is prioritized on providing exposure to prepare students to be able to produce appropriate speeches and expressions in the SAP class. Keyword: bahan ajar, listening, speaking, academic purposes
DASAR-DASAR FILOSOFIS METODE PEMBELAJARAN BAHASA PRANCIS SEBAGAI BAHASA ASING DI INDONESIA
Authors: Rahayu Siti Perdi
Published: May 2021

(Title: The Philosophical Foundations of the Learning Method of French as a Foreign Language in Indonesia). The aim of the current study is to describe the philosophical foundations used in learning French as a foreign language in Indonesia, specifically the language learning which refers to the CECR (Cadre Européen Commun de Rérence) or uniformity in learning, teaching and evaluation. This study adapts the  qualitative descriptive method. The data are in the form of features and characteristics of actionnelle approach, pragmatism and analytical linguistic philosophy foundations. Data are taken from sources such as documents including books on actionnelle approach, Echo 1 and Echo 2 books. Data analysis is done by making a comparative description of the characteristics of the actionnelle approach with the implementation of the philosophy of pragmatism education and the philosophy of analytical linguistic education. The findings of this study indicate that: 1) Pragmatism philosophy implies that education at every level must have criteria to be utilized and applied in social life, because students are indeed social actors, 2) Analytical linguistic philosophy has the principle that word meanings are in sentences, meaning of sentences in language , and the meaning of language exists in various life contexts, 3) Actionnelle approach is characterized by action, assimilating students as language users and as social actors who have tasks to do. The existence of the mentioned similarities can lead us to conclude that that the actionnelle approach gained influence from the philosophy of pragmatism and analytical linguistic.           Keywords: actionnelle approach; pragmatism philosophy;  analytical linguistic philosophy.
ANALISIS BENTUK DAN FAKTOR PENYEBAB PERUBAHAN MAKNA PEYORASI DAN AMELIORASI DALAM BERITA KRIMINAL
Authors: Ketriyawati Ketriyawati
Published: May 2021

(Title: Form Analysis and Factors That Cause Change in Peyoration and Amelioration Meanings in Criminal News). This study aims to analyze the changes in the meaning of peyoration and amelioration and the causes of changes in the meaning of peyoration and amelioration in the criminal news of the Radar Cirebon newspaper in the January 2019 edition. The research method used in this study is a qualitative method. Based on the data and results of the analysis, it can be concluded that the forms and changes in the meaning of the exploration and amelioration are in the form of words and phrases. Factors causing changes in the meaning of exploration and amelioration are factors of socio-cultural development, differences in usage fields, the existence of associations, and differences in responses. The results of the study can be used to develop class X Indonesian language subject matter in odd semseter with basic competence 3.15 analyzing aspects of meaning and language in biographies. In addition, research results can be a source of inspiration for journalists and journalists to be better in the selection and use of diction in writing criminal news. Hopefully, criminal news presented in the mass media, especially newspapers, is increasingly interesting by using variations in language and paying attention to the meaning contained there in.Keywords: change of meaning, exploration, amelioration, variety of journalism, criminal news
KEEFEKTIFAN PENDEKATAN COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) DALAM PEMBELAJARAN MEMBACA SASTRA
Authors: Apryliana Agnes
Published: May 2021

(Title: Effectiveness of Cooperative Integrated Reading and Composition (CIRC) Approaches in Literature Reading Learning) Learning to read literature based on the CIRC approach is an active and integrated learning activity that involves students and instructors as principals of learning. The ability to read is one of the abilities that requires ongoing learning. Applying the CIRC approach in learning to read literature becomes one of the solutions for teachers when learning activites begin. This study aims to (11) test the effectiveness of the CIRC approach in learning to read literature in PBSI Universitas Muhadi Setiabudi Brebes  Students in semester 1 of the 2018/2019 school year in reading subjects. This research is a quasi experimental research by comparing two approaches in learning, namely the conventional approach and the CIRC approach. The subject of the trial was PBSI UMUS students in semester 1 of the 2018/2019 school year. The research procedure had three stages, namely (1) the testing phase of the instrument of assessment and normally testing, (2) the learning phase, (3) the final test stage. Data collection using test techniques. The CIRC approach is more effective than the conventional approach, it is based on the resulting different test scores.Keywords: cooperative integrated reading and composition, reading, literature.
IDENTITAS KEINDONESIAAN DALAM DRAMA NYANYI SUNYI REVOLUSI KARYA AMIR HAMZAH
Authors: Rahayu Lina Meilinawati
Published: May 2021

(Title: Indonesian Identity in Drama’s Nyanyi Sunyi Revolusi by Amir Hamzah).This paper will examine the beginning period of Indonesia which is represented in the drama. The past events which occurred more than seventy years ago are now retold, not only to re-establish who Amir Hamzah was, but also to explain the Indonesian identity and the roles he played in building a nationality. Amir Hamzah, one of the great authors of Indonesia who also contributed in formulating the archipelago as Indonesia, who advocated Malay language as the language of unity of Indonesia, should be killed by several young men because he was a sultan’s nephew. Those young men considered the Sultans and their families as Dutch henchmen. The tragic story of Amir Hamzah’s life was staged in a drama titled “Nyanyi Sunyi Revolusi” (trans. The Quiet Singing of Revolution)which with the scripts was written by Ahda Imran. Socio-political conditions give rise to the need to define ‘self’. This requires serious rethinking. This drama also illustrates the identity of Indonesia after independence. In other words, literature describes history from a different view. By using the principle of New Historicism, this paper will explain the complex problem that occurred in Indonesia after independence until the 50s. Besides, it also will describe “Indonesian Identity” in the drama “Nyanyi Sunyi Revolusi”. In this context, Indonesian literary texts which reflect Indonesian history can be positioned as historical reading from a different version.Keywords: identity, Indonesian, revolution, new historicism.
FILOSOFI DAN PENDIDIKAN KARAKTER DALAM TEKS SÊRAT MÉNAK SARÉHAS DUMUGI MÉNAK SORANGAN MELALUI TOKOH AMIR AMBYAH
Authors: Hayuningtyas Amita , Ekowati Venny Indria
Published: May 2021

(Title: Philosophy and Character Education in the Text of “Sêrat Ménak Saréhas Dumugi Ménak Sorangan” through Amir Ambyah’s Character). This research is a philological study in the text of Sêrat Ménak Saréhas dumugi Ménak  Sorangan. Philosophical studies are in the form of an inventory, description, transliteration, edits and translations of the text of Saréhas dumugi Ménak Sorangan. This study aims to describe character education in the text of Sérat Ménak Saréhas dumugi Ménak Sorangan by using descriptive research methods. The object of the research is the text of Sérat Ménak Saréhas dumugi Ménak Sorangan. The way how to collect data in this research is by using a data card which is further described. There are 5 results of this study. First, the description of the text of Sérat Ménak Saréhas dumugi Ménak Sorangan is still intact andthe letters are still clear. Second, by using standard transliteration, the text of Sêrat Ménak Saréhas dumugi Ménak Sorangan which reads Javanese script is changed to Latin script. Third, using standard edition text edits, there are 5 words that get edits, then all changes in edited text are explained in the critics apparatus. Fourth, the results of text translation using bahasa Indonesia and the free translation method are related to the context. Fifth, the contents of the text of Sérat Ménak Saréhas dumugi Ménak Sorangan describe 9 pillars of character education, namely: (1) obedience to God, (2) responsibility, (3) wise, (4) respect and courtesy, (5) generous, love to help , (6) courageous, (7) kind and humble,(8) tolerance, peace and unity, and (9) leadership. The character education is related to the meaning of the illumination symbol wadånå gapurå rênggan in the text of Sérat Ménak Saréhas dumugi Ménak Sorangan.Keywords: Philological study, character education, illumination of wêdånå gapurå rênggan, Sêrat Ménak Saréhas dumugi Ménak Sorangan
THE REPRESENTATION OF FEMALE CHARACTER IN EDGE OF TOMORROW (2014) FILM BASED ON FEMINIST FILM CRITICS
Authors: Prismanisa Lana
Published: May 2021

(Title: The Representation of Female Character in “Edge of Tomorrow” (2014) Film Based on Feminist Film Critics). This research analyzes the female character in Edge of Tomorrow, Rita Vrataski. This research intends to understand how female character is described in the film and how female character is described according to feminist film critic. The method used is descriptive qualitative method. This research also uses theory character and characterization in film and theory feminist film critic. As the result, Rita is described as a female soldier who has characteristics as committed, brave, assertive, strong, muscular, intelligent and skillful soldier. Even though Rita, as the female character who has man’s characteristics, she still needs help from another male character. Rita character in this film is still passive because the one who finishes the mission in the story is the male character, William Cage. This film proves that male domination still exists in story of film. Thus, the female stereotype has been attached in film and it is difficult to change it.Keywords: female character ,women in film , feminist film critic