bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Features and Contributing Factors of Excessive Daytime Sleepiness in Chinese Obstructive Sleep Apnea Patients: The Role of Comorbid Symptoms and Polysomnographic Variables
Authors: Shao Chuan , Qi Huan , Lang Ruyi , Yu Biyun , Tang Yaodong , Zhang Lina , Wang Xun , Wang Ling
Published: July 2019

Background. The occurrence and severity of excessive daytime sleepiness (EDS) vary considerably among obstructive sleep apnea (OSA) patients. This study was designed to investigate the characteristics of EDS and identify its contributing factors in OSA patients.Methods. This was a cross-sectional study from a tertiary medical center in China. A total of 874 consecutive patients with newly diagnosed OSA were included. Subjective daytime sleepiness was assessed with the Epworth Sleepiness Scale (ESS). The subjects were assigned to the non-EDS group (582 patients), mild to moderate EDS group (227 patients), and severe EDS group (65 patients) according to the ESS scores. The clinical features and polysomnographic parameters were acquired and analyzed to identify the differences between groups and the determinants of EDS.Results. The age of patients with severe EDS (49.5 ± 11.3) was slightly greater than that of patients with mild to moderate EDS (44.5 ± 10.2) (p<0.05) and non-EDS patients (45.2 ± 12.0) (p<0.05). Body mass index (BMI) was highest in the severe EDS group (29.1 ± 3.6 kg/m2) (p<0.0001), intermediate in the mild to moderate EDS group (27.9 ± 3.3 kg/m2), and lower in the non-EDS group (26.8 ± 3.3 kg/m2). Logistic regression analysis showed waist circumference, memory loss, work/commute disturbances, and sleep efficiency were independently associated with mild to moderate EDS, and the microarousal index, apnea-hypopnea index (AHI), and saturation impair time below 90% were independent contributing factors of mild to moderate EDS. Meanwhile, age, neck circumference, gasping/choking, memory loss, work/commute disturbances, and sleep latency were independently associated with severe EDS, and the AHI and mean SpO2were independent contributing factors of severe EDS.Conclusions. OSA patients with various severities of EDS are more obese and have more comorbid symptoms compared to patients without EDS. Sleep fragmentation, respiratory events, and nocturnal hypoxia may be predictors of EDS. Comprehensive consideration of demographic, clinical, and polysomnographic factors is required when evaluating OSA patients.
Determination of Intervening Pillar Thickness Based on the Cusp Catastrophe Model
Authors: Ma Shaowei , Luo Zhouquan , Hu Jianhua , Ren Qifan , Qin Yaguang , Wen Lei
Published: July 2019

For the stability of the intervening pillar of the sublevel drilling open‐stope subsequent filling mining method, the multifactor stability mechanical model of the intervening pillar under two different constraint conditions (Model 1 and Model 2) was established based on the elastic thin plate theory. Then, the cusp catastrophe equation and the necessary and sufficient conditions for the instability of the intervening pillar under two different constraint conditions were obtained by using the cusp catastrophe theory. Furthermore, the minimum thickness formula for the intervening pillar without instability under two different constraint conditions was derived, and the relationships between the minimum thickness of the intervening pillar and the factors, including the depth of the stope, the inclination of the orebody, the thickness of the orebody, the height of the stage, the length of the stope, and the mechanical properties of the orebody, were analyzed. Finally, the formula was used in the design of an intervening pillar between stopes 4‐1 and 4‐2 in Panlong Lead‐Zinc Mine. The designed thickness of the pillar was 6.01 m by calculation, its actual thickness was 6.35–7.25 m in the mining process, and its average thickness was 6.5 m. Compared with the previously designed thickness of 7‐8 m at the same stage, the pillar was 0.5–1.5 m smaller, which more effectively improved the recovery rate of the ore under the premise of ensuring the stability of the intervening pillar. This example of industrial application proves that it is feasible to use the cusp catastrophe theory to analyze the stability and parameter design of the intervening pillar under different constraints.
An Improved Critical‐Edge Model for Finding Optimal Contraflow Links Considering the Influence of Intersections
Authors: Mo Junwen , Gao Mingxia , Liu Liqiao
Published: July 2019

A reversible roadway (contraflow) is one in which the direction of traffic flow in one or more lanes is reversed to the opposing direction for some period of time. Reversible roadways are most commonly used for accommodating directionally imbalanced traffic associated with daily commuter periods. Reversible lanes also have been widely used, in recent years, for evacuating major metropolitan regions threatened by hurricanes and other disasters. One important problem in the practice of evacuation traffic organization is the choice of road links for contraflow. Most research on the choice of contraflow links does not consider the influence of intersections, which leads to overestimation of evacuation capacity especially in congested urban road networks. We abstract an evacuation road network as a special network with directional node‐weights by considering the capacity of intersection movements as directed weights of nodes. We define the critical edge for increasing the maximum flow value of such network as the one that can maximize the range of flow value increase by expanding its capacity. We obtain alternative links for contraflow by searching critical edges in such network. We presented a modified algorithm for finding such critical edges on the basis of the maximal capacity path algorithm for the classical maximum flow problem. We also provided a numerical example and tested the effects through traffic simulation. Our results show that the results considering the influence of intersections are more reasonable than those ignoring it and that taking the intersection effects into account enables us to reduce the total evacuation time.
Investigation of Fresh and Hardened Characteristics of Self‐Compacting Concrete with the Incorporation of Ethylene Vinyl Acetate and Steel‐Making Slag
Authors: Khan Kashif Ali , Nasir Hassan , Alam Muhammad , Wali Khan Sajjad , Ahmad Izhar , Rehman Zia Ur
Published: July 2019

Advancement in the construction industry causes decline in the availability of natural resources, and this decline can be overcome by utilization of the available raw materials. This study is focused on the combined effects of ethylene vinyl acetate (EVA) and ladle furnace slag (LFS) on fresh and hardened characteristics of self‐compacting concrete (SCC) by replacing some fraction of cement and sand. The characteristics of SCC in its fresh state are investigated by workability, while hardened characteristics are investigated by elastic modulus and compressive, tensile, and flexural strength. The findings showed that the workability is enhanced by the incorporation of EVA, while decreased with LFS. Furthermore, all the strength properties were enhanced at all the replacement levels of EVA and LFS except for the splitting tensile strength. The utmost gain in elastic modulus and compressive, tensile, and flexural strength was up to 18, 20, 10, and 15% more by increasing the dosage of LFS while keeping EVA constant.
Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content
Authors: Morcelle Carmen , Menoyo Sandra , Morón-Duran Francisco D. , Tauler Albert , Kozma Sara C. , Thomas George , Gentilella Antonio
Published: July 2019

The role of MYC in regulating p53 stability as a function of increased ribosome biogenesis is controversial. On the one hand, it was suggested that MYC drives the overexpression of ribosomal proteins (RP)L5 and RPL11, which bind and inhibit HDM2, stabilizing p53. On the other, it has been proposed that increased ribosome biogenesis leads the consumption of RPL5/RPL11 into nascent ribosomes, reducing p53 levels and enhancing tumorigenesis. Here, we show that the components that make up the recently described impaired ribosome biogenesis checkpoint (IRBC) complex, RPL5, RPL11, and 5S rRNA, are reduced following MYC silencing. This leads to a rapid reduction in p53 protein half-life in an HDM2-dependent manner. In contrast, MYC induction leads to increased ribosome biogenesis and p53 protein stabilization. Unexpectedly, there is no change in free RPL5/RPL11 levels, but there is a striking increase in IRBC complex bound to HDM2. Our data support a cell-intrinsic tumor-suppressor response to MYC expression, which is presently being exploited to treat cancer.

Significance:

Oncogenic MYC induces the impaired ribosome biogenesis checkpoint, which could be potentially targeted for cancer treatment.
DNA–SWCNT Biosensors Allow Real-Time Monitoring of Therapeutic Responses in Pancreatic Ductal Adenocarcinoma
Authors: Bhattacharya Santanu , Gong Xun , Wang Enfeng , Dutta Shamit K. , Caplette Joseph R. , Son Manki , Nguyen Freddy T. , Strano Michael S. , Mukhopadhyay Debabrata
Published: July 2019

Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic cancer with limited treatment options. There is an urgent need for tools that monitor therapeutic responses in real time. Drugs such as gemcitabine and irinotecan elicit their therapeutic effect in cancer cells by producing hydrogen peroxide (H2O2). In this study, specific DNA-wrapped single-walled carbon nanotubes (SWCNT), which precisely monitor H2O2, were used to determine the therapeutic response of PDAC cells in vitro and tumors in vivo. Drug therapeutic efficacy was evaluated in vitro by monitoring H2O2 differences in situ using reversible alteration of Raman G-bands from the nanotubes. Implantation of the DNA–SWCNT probe inside the PDAC tumor resulted in approximately 50% reduction of Raman G-band intensity when treated with gemcitabine versus the pretreated tumor; the Raman G-band intensity reversed to its pretreatment level upon treatment withdrawal. In summary, using highly specific and sensitive DNA-SWCNT nanosensors, which can determine dynamic alteration of hydrogen peroxide in tumor, can evaluate the effectiveness of chemotherapeutics.

Significance:

A novel biosensor is used to detect intratumoral hydrogen peroxide, allowing real-time monitoring of responses to chemotherapeutic drugs.
Molecular Profiling Establishes Genetic Features Predictive of the Efficacy of the p110β Inhibitor KIN-193
Authors: Sethi Isha , Cai Zhenying , Roberts Thomas M. , Yuan Guo-Cheng
Published: July 2019

Aberrant activation of the PI3K pathway is a common alteration in human cancers. Therapeutic intervention targeting the PI3K pathway has achieved limited success due to the intricate balance of its different components and isoforms. Here, we systematically investigated the genomic and transcriptomic signatures associated with response to KIN-193, a compound specifically targeting the p110β isoform. By integrating genomic, transcriptomic, and drug response profiles from the Genomics of Drug Sensitivity in Cancer database, we identified mutational and transcriptomic signatures associated with KIN-193 and further created statistical models to predict the treatment effect of KIN-193 in cell lines, which may eventually be clinically valuable. These predictions were validated by analysis of the external Cancer Cell Line Encyclopedia dataset. These results may assist precise therapeutic intervention targeting the PI3K pathway.

Significance:

These findings provide new insights into molecular signatures associated with sensitivity of the p110β inhibitor KIN-193, which may provide a useful guide for developing precise treatment methods for cancer.
BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14
Authors: Hillman Joanna C. , Pugacheva Elena M. , Barger Carter J. , Sribenja Sirinapa , Rosario Spencer , Albahrani Mustafa , Truskinovsky Alexander M. , Stablewski Aimee , Liu Song , Loukinov Dmitri I. , Zentner Gabriel E. , Lobanenkov Victor V. , Karpf Adam R. , Higgins Michael J.
Published: July 2019

High-grade serous carcinoma (HGSC) is the most aggressive and predominant form of epithelial ovarian cancer and the leading cause of gynecologic cancer–related death. We have previously shown that CTCFL (also known as BORIS, Brother of the Regulator of Imprinted Sites) is expressed in most ovarian cancers, and is associated with global and promoter-specific DNA hypomethylation, advanced tumor stage, and poor prognosis. To explore its role in HGSC, we expressed BORIS in human fallopian tube secretory epithelial cells (FTSEC), the presumptive cells of origin for HGSC. BORIS-expressing cells exhibited increased motility and invasion, and BORIS expression was associated with alterations in several cancer-associated gene expression networks, including fatty acid metabolism, TNF signaling, cell migration, and ECM–receptor interactions. Importantly, GALNT14, a glycosyltransferase gene implicated in cancer cell migration and invasion, was highly induced by BORIS, and GALNT14 knockdown significantly abrogated BORIS-induced cell motility and invasion. In addition, in silico analyses provided evidence for BORIS and GALNT14 coexpression in several cancers. Finally, ChIP-seq demonstrated that expression of BORIS was associated with de novo and enhanced binding of CTCF at hundreds of loci, many of which correlated with activation of transcription at target genes, including GALNT14. Taken together, our data indicate that BORIS may promote cell motility and invasion in HGSC via upregulation of GALNT14, and suggests BORIS as a potential therapeutic target in this malignancy.

Implications:

These studies provide evidence that aberrant expression of BORIS may play a role in the progression to HGSC by enhancing the migratory and invasive properties of FTSEC.
Percutaneous Intratumor Laser Ablation for Fetal Sacrococcygeal Teratoma
Authors: Litwińska Magdalena , Litwińska Ewelina , Janiak Katarzyna , Piaseczna-Piotrowska Anna , Szaflik Krzysztof
Published: July 2019

Objective: To evaluate the efficiency of percutaneous intratumor laser ablation for fetal solid sacrococcygeal teratoma (SCT). Subjects and Methods: We carried out percutaneous ultrasound-guided intratumor laser ablation through a 17-gauge needle using an output of 40 W in 7 fetuses with large solid SCT and reviewed the literature for minimally invasive therapy for this condition. Results: Laser ablation was carried out at a median gestational age of 20 (range 19–23) weeks, and in all cases there was elimination of obvious vascularization within the tumor and improvement in cardiac function. Three (43%) babies survived and had surgical excision of the tumor within 2 days of birth, 3 liveborn babies died within 5 days of birth and before surgery, and 1 fetus died within 2 weeks after the procedure. In previous series of various percutaneous interventions for predominantly solid SCT the survival rate was 33% (2/6) (95% CI 9.7–70%) for endoscopic laser to superficial vessels, 57% (4/7) (95% CI 25–84%) for intratumor laser, 67% (8/12) (95% CI 39–86%) for intratumor radiofrequency ablation, and 20% (1/5) (95% CI 3.6–62%) for intratumor injection of alcohol. Conclusions: In solid SCT, the reported survival from intratumor laser or radiofrequency ablation is about 50%, but survival does not mean success, and it remains uncertain whether such interventions are beneficial or not because the number of fetuses is small and there were no controls that were managed expectantly.
A Potential Mechanism of Cardio-Renal Protection with Sodium-Glucose Cotransporter 2 Inhibitors: Amelioration of Renal Congestion
Authors: Kuriyama Satoru
Published: July 2019

Background: This review considers anew the etiology of the cardio-renal protective effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors by extending the discussion to renal congestion, inherent in diabetic kidney disease (DKD) even at an early stage of nephropathy in which heart failure (HF) or salt and water accumulation is asymptomatic. Summary: The interstitial fluid (IF) space of the kidney space plays a crucial role for tubulointerstitial inflammation, renal hypoxia, and ischemic injury, which often leads to renal progression. In DKD, as a result of hyperglycemic milieu, excessive salt and water can be accumulated in the IF space, creating renal congestion. I hypothesize that SGLT2 inhibitors cause a shift in extracellular water from the IF space to the intravascular space to compensate for the SGLT2 inhibitor-induced hypovolemia. This decrease in IF volume ameliorates the IF space milieu and may reduce inflammation, hypoxia, and ischemic injury. Message: The present review proposes a novel theory; unlike other hypoglycemic agents or diuretics, SGLT2 inhibitor could protect DKD from failing by improving latent renal congestion even without symptomatic HF.
Reduction in Aortic Pulse Wave Velocity Is Associated with a Short-Term Reduction in Dual-Energy X-Ray Absorptiometry Lumbar Spine Bone Mineral Density T Score
Authors: Tangvoraphonkchai Kamonwan , Davenport Andrew
Published: July 2019

Introduction: Increased vascular stiffness is a risk factor for mortality. We wished to determine whether changes in vascular stiffness are associated with changes in bone mineral density (BMD) in peritoneal dialysis patients. Methods: We measured vascular stiffness by aortic pulse wave velocity (aPWV) and BMD by dual electron absorptiometry (DXA) scanning and compared T scores to compensate for differences in patient ages and gender. Results: Twenty-four patients had repeat aPWV measurements and DXA scans, median 12.4 months apart. aPWV decreased in 15 and increased in 9. As there were more women in the group with an increase in aPWV, we used gender-adjusted DXA T scores Total body T scores fell in both groups, but median T scores remained positive for those with an increase in aPWV, whereas negative T scores on both scans for those with a decrease in or stable aPWV. Lumbar spine T scores fell in those with a reduction in aPWV (–1.6 [–2.4 to 0.6] to –2.1 [–2.4 to 0.3], p < 0.05), whereas there was no significant decrease in those with an increase in aPWV (–0.5 [–1.1 to 0.15] to –0.7 [–1.7 to 0.6]). There were no changes in femoral neck T scores. Conclusions: Our study reinforces the hypothesis of a link between bone disease and vascular disease in dialysis patients. Lumbar spine DXA includes imaging of the aorta and will include aortic calcification, and as such a reduction in lumbar spine T score without a change in femoral neck T score suggests a reduction in aortic calcification. Although our study requires additional confirmation, our data would suggest that changes in aPWV could be used as a surrogate for changes in vascular calcification in the investigation of interventions designed to reduce vascular calcification.
Different Treatments for Granulomatous Lobular Mastitis: A Systematic Review and Meta-Analysis
Authors: Ma Xiaojia , Min Xiaoli , Yao Chang
Published: July 2019

Objective: Granulomatous lobular mastitis (GLM) is infrequently diagnosed. This study aimed to evaluate the efficacy and safety of managements for GLM in the nonlactation period. Methods: Publications were retrieved from PubMed, EMBASE, and the Cochrane library on September 10, 2018. We pooled and compared the outcome parameters and complete remission (CR) rates between different treatments using a meta-analysis. Results: Twenty-one publications including 970 patients treated with surgical excision, steroids, abscess drainage, antibiotics, and observation were included. Surgery significantly improved CR rate compared with steroids (p = 0.0003). There was no difference in the CR rate in patients treated with surgery alone or combined with steroids (p = 0.28). Surgery showed borderline significant efficacy in the CR rate compared with antibiotics (p = 0.06) and abscess drainage (p = 0.06). No difference was observed in effectiveness between observation and surgical management in patients diagnosed with early GLM and mild symptoms. Conclusions: Although surgery was the ideal management for GLM, steroids and antibiotics might be ideal managements for GLM patients who are worried about surgical scars. Observation was an impressive alternative for patients with early GLM.
Efficacy and Safety of Endovascular Thrombectomy for Ischemic Stroke in Nonagenarians
Authors: Wu Qisi , Li Qi , Huang Cheng , Li Yongmei , Wolff Valérie , Qin Xinyue
Published: July 2019

Introduction: Increased life expectancy results in a rapid increase of nonagenarian patients presenting with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). We conducted this study to assess the efficacy and safety of endovascular thrombectomy (ET) in this age group with use of imaging-based selection. Methods: We retrospectively analyzed clinical and imaging data from 2 different comprehensive stroke centers and compared the outcomes of ET versus intravenous thrombolysis (IVT) alone among eligible nonagenarians with LVO in anterior circulation and evidence of salvageable tissue on brain magnetic resonance imaging (MRI). Results: A total of 617 patients of AIS had been treated with IVT or ET, including 23 eligible nonagenarians. Among these, 9 patients were treated with IVT alone (IVT group) and 14 patients received ET group. Notably, the symptomatic intracranial hemorrhage rates were significantly lower after ET than after IVT (European-Australasian Acute Stroke Study II criteria, 0 vs. 33.3%; p = 0.047; National Institute of Neurological Disorders and Stroke criteria, 7.1 vs. 66.7%; p = 0.005). Moreover, although there were no statistically significant differences between the 2 groups on efficacy, ET tended to lead to greater early neurologic recovery at discharge (71.4 vs. 33.3%, p = 0.102) and improve functional outcome at 90 days (71.4 vs. 44.4%, p = 0.383), respectively. Conclusion: By using MRI-based selection, ET in nonagenarians with AIS caused by LVO within anterior circulation was safe and may lead to improve early neurologic recovery and functional independence at 90 days, as compared with IVT alone. Randomized trial in larger sample size testing efficacy of ET using diffusion-weighted imaging-fluid attenuated inversion recovery mismatch selection in this age group appears feasible.
Association between the ACYP2 Polymorphisms and IgAN Risk in the Chinese Han Population
Authors: Jin Gang , Liang Yan , Yan Xiaohui , Zhang Linping , Li Zhenjiang , Yin Aiping , Wang Xiaoming , Tian Puxun
Published: July 2019

Background/Aims: The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. Methods: Eleven ACYP2 single nucleotide polymorphisms (SNPs) from 416 IgAN patients and 495 healthy controls were genotyped using the Sequenom MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were calculated to evaluate the association of ACYP2 polymorphisms with IgAN risk. Results: We observed that rs843720 was significantly associated with an increased risk of IgAN (allele G: OR = 1.23, 95% CI: 1.01–1.49, p = 0.036; dominant model: OR = 1.55, 95% CI: 1.01–2.37, p =0.044; log-additive model: OR = 1.43, 95% CI: 1.04–1.95, p = 0.026) before Bonferroni correction. The SNP rs12615793 was also significantly associated with an increased IgAN risk in the recessive model (OR = 3.33, 95% CI: 1.05–10.51, p = 0.042) before Bonferroni correction. Conclusion: These findings suggested that polymorphisms (rs843720 and rs12615793) of ACYP2 may be pivotal in the development of IgAN. However, more functional and association studies with larger sample sizes should be performed to further validate our results in the future.
The Melted Statue of Charcot: The Nazi Occupation of Paris During World War II
Authors: Teive Hélio A.G. , Tensini Fernando , Germiniani Francisco M.B. , Camargo Carlos Henrique F. , Walusinski Olivier
Published: July 2019

The authors describe the construction of a statue in honor of Professor Charcot, the father of modern neurology, in Paris in 1898, 5 years after his death. The Nazi invaders destroyed the statue, which was erected near the entrance to the Salpêtrière hospital with the support of his disciples and the international neurological community, in 1942 during World War II. An international campaign is now needed to rebuild the statue of this great neurologist.
Samatradução: a audição tradutória
Authors: Yunis Leandra
Published: July 2019

No presente artigo a autora comenta algumas operações tradutórias do método experimental desenvolvido em sua prática com a tradução direta do persa de alguns poemas místicos. Com base na teoria da imaginação de Ibn Arabi (1165-1240) e na doutrina da audição mística de Alghazali (1058-1111), propõe-se a adaptação de alguns procedimentos místicos para fins tradutórios. A reescrita de um gazal do mestre sufi Jalal Uddin Rumi (1207-1273) serve de fio condutor para demonstrar como seria a “audição tradutória” pelo método intuitivo.
O perfil de tradutores de textos especializados atuantes no mercado brasileiro
Authors: Vilela Wisley Do Carmo , Pimentel Janine
Published: July 2019

A tradução de textos sobre assuntos técnicos e especializados está pervasivamente presente na vida do brasileiro mediano. Não obstante a ampla disseminação desse tipo de conteúdo traduzido, pouco se percebe, nesse cenário, a figura do tradutor. O objetivo deste artigo é analisar os dados coletados em pesquisa de sondagem sobre o perfil de tradutores atuantes no mercado brasileiro de tradução especializada. Existem estudos deste tipo sobre outros mercados (norte-americano e europeu), como por exemplo o trabalho pioneiro de Venuti (1995) que denunciou a invisibilidade do tradutor literário, mas poucos sobre o mercado brasileiro de tradução especializada. Nesta pesquisa, obtiveram-se respostas relacionadas à percepção que os profissionais de tradução têm de si mesmos e das condições de trabalho atuais nesse mercado.
Antropofagia Literária e Literal na sua relação com os Estudos da Tradução
Authors: Vieira Filho Edgar Rosa
Published: July 2019

O presente ensaio tem como objetivo realizar uma apreciação crítica das reflexões que deslocam a metáfora/conceito antropofágico oswaldiano e, mais recentemente, o ritual antropófago via estudos sobre perspectivismo ameríndio em Viveiros de Castro, para o campo dos Estudos da Tradução. A fim de se compreender a relação e os desdobramentos suscitados pela associação entre Antropofagia e prática tradutória, buscou-se distinguir, pautando-se na proposição terminológica do antropólogo brasileiro Carlos Fausto, as diferentes bases/fontes que orientam tais reflexões aproximativas.

Palavras-chave: Antropofagia modernista; Perspectivismo ameríndio; Estudos da Tradução; Xamanismo; Alteridade.
Os Gatos e o Neko de Natsume Sôseki: Uma análise sobre as personagens felinas de eu sou um gato
Authors: Afonso Joy Nascimento
Published: July 2019

O presente artigo procura entender como se dá a construção das personagens felinas no romance Eu sou um Gato de Natsume Sôseki. Primeiro retomamos várias concepções da figura do gato na literatura universal, e as comparamos com a personagem principal do romance, que em muitos aspectos é uma paródia de várias figuras lendárias. Tendo como propósito ressaltar as mudanças sociais do período Meiji (1868-1912), assim como, criticar por meio do vocabulário das personagens as estratificações sociais do período citado.
Da Indissociabilidade entre literatura e sociedade a partir de “Patriotismo” (1961) de Mishima Yukio
Authors: Santos Rafael Felipe dos , Sparemberger Alfeu
Published: July 2019

A partir da reflexão sobre um dos mais célebres contos do escritor Mishima Yukio, conhecido por recorrer ao tópico do suicídio inúmeras vezes, pretende-se mostrar que a autoimolação reveste-se, seja em “Patriotismo” (1961) e repetidas vezes em outras obras de sua autoria, de uma forte referência cultural. Diferentemente da visão atribuída no ocidente de que a rigidez da sociedade nipônica e suas convenções são as responsáveis por fragilizar mentalmente os indivíduos a ponto de eles cometerem suicídio, parte-se do preceito de que é absolutamente necessário ampliar as categorias de entendimento na percepção de uma cultura fundada em ideais ainda mal elucidados aos que nela não estão inseridos. Acredita-se que talvez a literatura seja o caminho para tal esclarecimento, uma vez que ela não pode ser isolada da cultura da qual provém.
A escrita feminina japonesa: Um breve panorama das produções clássicas às contemporâneas
Authors: Afonso Joy Nascimento , Leal Priscila Yamaguchi
Published: July 2019

Quando observamos a produção literária japonesa contemporânea notamos que as publicações de mulheres têm se quantificado proporcionalmente a dos homens. Mas qual têm sido as características dessas produções? Há características em sua escrita que as distinguem dos homens? Neste trabalho, nosso objetivo é disponibilizar um panorama sucinto dessas obras de autoria feminina vertidas para o português e entender baseando-nos na produção das autoras Banana Yoshimoto e Hiromi Kawakami quais são as características dessa escrita feminina e como ela se dá no âmbito dos estudos japoneses. Tentando entender essa produção não somente como um reflexo da sociedade atual japonesa, mas também como forma de ver o homem universal em seu processo continuo de se entender.
Imigração Japonesa para o Amazonas no Pós-Guerra sob a perspectiva dos hábitos alimentares: (1953-1967)
Authors: Nishikido Linda Midori Tsuji
Published: July 2019

Esta investigação visa reconstruir e reinterpretar a história da imigração japonesa para o Amazonas no pós-guerra, por meio dos hábitos alimentares, com enfoque para a Colônia Bela Vista e Colônia Efigênio de Salles, do período que compreende entre a retomada da imigração japonesa (1953) e a implantação da Zona Franca de Manaus (1967). Empregou-se como método a história oral, realizando as entrevistas como meio para coletar as informações. Como fundamentação teórica, adotou-se os preceitos de Jacks Le Goff que alça discussões sobre Memória e História, elementos norteadores da investigação. A importância da temática está atrelada ao fato de que alimentar-se para o ser humano não se resume apenas em saciar a fome, mas encontra-se carregada de simbologias que culminam na identificação de uma etnia. Nesse sentido, desenvolveu-se, por meio dos hábitos alimentares, aspectos relativos a sociedade e cultura dos imigrantes japoneses no Amazonas, estruturados nas práticas alimentares.
CONSIDERAÇÕES SOBRE A APOSTA DE PASCAL
Authors: Oliva Luís César Guimarães
Published: July 2019

Este artigo pretende expor a estrutura argumentativa do famoso fragmento pascaliano sobre a aposta, cujo intuito principal é mostrar a maior razoabilidade da vida do cristão em comparação com a do não cristão. Partindo da indemonstrabilidade da existência ou inexistência de Deus, o fragmento desenvolve uma argumentação racionalmente aceitável para justificar que se aposte no incerto, sobretudo quando o infinito está em jogo.
“UM NADA EM RELAÇÃO AO INFINITO”: O ANIQUILAMENTO NA COMPARAÇÃO PASCALIANA
Authors: Cortese João Figueiredo Nobre
Published: July 2019

Tanto nos Pensamentos quanto em seus trabalhos matemáticos, Pascal faz referência ao “nada”, assim como a um processo que poderíamos chamar de “aniquilamento” (seguindo o termo do fragmento Sellier 680, Lafuma 418), segundo o qual aquilo que é finito se torna um nada diante do infinito. O “nada” pascaliano, segundo a interpretação aqui defendida, pode ter, em diferentes passagens da obra do autor, uma acepção relativa ou uma acepção absoluta, o que vale também para os termos de “infinito”, “desproporção” e “indivisível” na obra de Pascal. Além do valor de tal análise para os Pensamentos, ela se propõe mostrar certa proximidade estrutural entre as obras matemáticas e apologéticas de Pascal.
Impact of Diabetes Mellitus in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents
Authors: Baber Usman , Stefanini Giulio G. , Giustino Gennaro , Stone Gregg W. , Leon Martin B. , Sartori Samantha , Aquino Melissa , Steg P. Gabriel , Windecker Stephan , Wijns William , Serruys Patrick W. , Valgimigli Marco , Morice Marie–Claude , Camenzind Edoardo , Weisz Giora , Smits Pieter C. , Kandzari David E. , von Birgelen Clemens , Dangas George D. , Galatius Soren , Jeger Raban V. , Kimura Takeshi , Mikhail Ghada W. , Itchhaporia Dipti , Mehta Laxmi , Ortega Rebecca , Kim Hyo-Soo , Kastrati Adnan , Chieffo Alaide , Mehran Roxana
Published: July 2019

Background:

Data examining the impact of diabetes mellitus (DM) on ischemic risk after percutaneous coronary intervention in women are limited as most clinical trial participants are male. We evaluated (1) the impact of DM on ischemic outcomes in women undergoing drug-eluting stent (DES) implantation and (2) whether the outcomes of new- versus early-generation DES vary by DM status.

Methods and Results:

We pooled patient-level data of 10 448 women undergoing percutaneous coronary intervention with DES from 26 randomized trials. Baseline characteristics and 3-year clinical outcomes were stratified according to DM status (noninsulin-dependent and insulin-dependent) and DES generation. The primary end point was the composite of all-cause death or myocardial infarction. Secondary end points were definite or probable stent thrombosis and target lesion revascularization. Compared with women without DM (n=7154, 68.5%), adjusted risks (adjusted hazard ratios [95% CI]) for death or myocardial infarction among women with noninsulin-dependent DM (n=2241, 21.4%) and insulin-dependent DM (n=1053, 10.1%) were 1.30 (1.11–1.53) and 1.71 (1.41–2.07), respectively (
P
trend
<0.001). Similar trends were observed for def/prob stent thrombosis and target lesion revascularization. Compared with early-generation DES, use of newer-generation DES was associated with significant reductions in death or myocardial infarction in the absence of DM whereas differences were nonsignificant in the presence of DM, with similar findings for def/prob stent thrombosis and target lesion revascularization.

Conclusions:

The presence of DM is associated with substantial, graded, and durable risks for ischemic events among women undergoing percutaneous coronary intervention with DES. The safety and efficacy profile of newer-generation DES is preserved among women without DM, while benefits are nonsignificant among women with DM.
Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage
Authors: Beyhoff Niklas , Lohr David , Foryst-Ludwig Anna , Klopfleisch Robert , Brix Sarah , Grune Jana , Thiele Arne , Erfinanda Lasti , Tabuchi Arata , Kuebler Wolfgang M. , Pieske Burkert , Schreiber Laura M. , Kintscher Ulrich
Published: July 2019

Subendocardial damage is among the first cardiac manifestations of hypertension and is already present in asymptomatic disease states. Accordingly, markers of subendocardial impairment may facilitate early detection of cardiac damages and risk stratification under these conditions. This study aimed to investigate the impact of subendocardial damage on myocardial microstructure and function to elucidate early pathophysiologic processes and to identify corresponding diagnostic measures. Mice (n=38) were injected with isoproterenol to induce isolated subendocardial scarring or saline as corresponding control. Cardiac function and myocardial deformation were determined by high-frequency echocardiography. The cardiac stress response was assessed in a graded exercise test and during dobutamine stress echocardiography. Myocardial microstructure was studied ex vivo by 7 T diffusion tensor magnetic resonance imaging at a spatial resolution of 100×100×100 µm

3

. Results were correlated with histology and biomarker expression. Subendocardial fibrosis was accompanied by diastolic dysfunction, impaired longitudinal deformation (global peak longitudinal strain [LS]: −12.5±0.5% versus −15.6±0.5%;
P
<0.001) and elevated biomarker expression (ANP [atrial natriuretic peptide], Galectin-3, and ST2). Systolic function and cardiac stress response remained preserved. Diffusion tensor magnetic resonance imaging revealed a left-shift in helix angle towards lower values in isoproterenol-treated animals, which was mainly determined by subepicardial myofibers (mean helix angle: 2.2±0.8° versus 5.9±1.0°;
P
<0.01). Longitudinal strain and subepicardial helix angle were highly predictive for subendocardial fibrosis (sensitivity, 82%–92% and specificity, 89%–90%). The results indicate that circumscribed subendocardial damage alone can cause several hallmarks observed in cardiovascular high-risk patients. Microstructural remodeling under these conditions involves also remote regions, and corresponding changes in longitudinal strain and helix angle might serve as diagnostic markers.
Thrombectomy Results in Reduced Hospital Stay, More Home-Time, and More Favorable Living Situations in DEFUSE 3
Authors: Tate William J. , Polding Laura C. , Kemp Stephanie , Mlynash Michael , Heit Jeremy J. , Marks Michael P. , Albers Gregory W. , Lansberg Maarten G.
Published: July 2019

Background and Purpose—

The DEFUSE 3 trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke) demonstrated that endovascular thrombectomy in the 6- to 16-hour time window improves functional outcomes of patients with evidence of salvageable tissue on baseline computed tomography or magnetic resonance imaging. The purpose of this study is to assess the effect of endovascular therapy on length of hospital stay, home-time during the first 3 months poststroke, and living situation poststroke in DEFUSE 3.

Methods—

Duration of hospital stay and home-time (number of days during the 90-day poststroke period that the patient resides in their own home or in that of a relative) were compared between treatment groups using the Wilcoxon rank-sum test. Patient living situation was assessed at discharge, 30 days, and 90 days on an ordinal 4-point scale (home, acute rehabilitation unit, institutionalized care, or hospice/death) and differences between groups were analyzed using the Cochran-Armitage trend test.

Results—

Median length of hospital stay was 9.1 (interquartile range, 6.2–15.0) days in the medical group versus 6.5 (interquartile range, 3.7–9.3) days in the endovascular group (
P
<0.001). Median home-time during the first 90 days after stroke was 0 (interquartile range, 0–53) days in the medical group versus 55 (interquartile range, 0–83) days in the endovascular group (
P
<0.001). The endovascular group had more favorable living situations at time of discharge (
P
<0.001), 30 days (
P
<0.001), and 90 days (
P
<0.001) poststroke.

Conclusions—

Endovascular thrombectomy resulted in reduced hospital stay, more home-time, and more desirable living situations in the 90 days after stroke. These results provide evidence that endovascular therapy in the delayed time window can improve quality of life for stroke patients and reduce healthcare costs.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02586415.
Derivo Embolization Device for the Treatment of Intracranial Aneurysms
Authors: Trivelato Felipe Padovani , Abud Daniel Giansante , Ulhôa Alexandre Cordeiro , Waihrich Eduardo Siqueira , Abud Thiago Giansante , Castro Afonso Luis Henrique , Nakiri Guilherme Seizem , de Castro Guilherme Duarte , Parente Bruno de Sousa Mendes , dos Santos Silva Rodrigo , Manzato Luciano Bambini , Bonadio Lucas Eduardo , Viana Dinark Conceição , Vanzin José Ricardo , Baccin Carlos Eduardo , Rezende Marco Túlio Salles
Published: July 2019

Background and Purpose—

Flow diverter technology improvements are necessary to provide safe and good results and enable the treatment of a larger variety of aneurysms. We report a nationwide experience with the Derivo Embolization Device in the treatment of intracranial aneurysms.

Methods—

BRAIDED (Brazilian Registry of Aneurysms Assigned to Intervention With the Derivo Embolization Device) is a multicenter, prospective, interventional, single-arm trial of the Derivo Embolization Device for the treatment of intracranial aneurysms. The primary effectiveness end point was total aneurysm occlusion at 6- and 12-month angiographies. The secondary safety end point was the absence of serious adverse events during follow-up. Univariable and multivariable logistic regression was performed to identify predictors of aneurysm persistence, periprocedural complications, and adverse events during follow-up.

Results—

Between December 2016 and October 2018, 146 patients harboring 183 intracranial aneurysms were treated in 151 interventions at 7 centers. Derivo Embolization Device placement was technically successful in all patients. Most aneurysms (86.9%) were located at the internal carotid artery, and the mean diameter was 6.7 mm. At 6 months, 113 of 140 (80.7%) aneurysms met the study’s primary end point, and 74 of 83 (89.2%) met the study’s primary end point at 12 months. Saccular morphology of the aneurysm (odds ratio, 5.66; 95% CI, 1.01–31.77) and the presence of a branch arising from the sac (odds ratio, 6.36; 95% CI, 2.11–22.36) predicted persistence. A long duration of follow-up (odds ratio, 0.86; 95% CI, 0.78–0.95) predicted total occlusion. Of the 146 enrolled patients, 138 (94.5%) were treated without serious adverse events during follow-up. In the multivariable analysis, aneurysms located at a sidewall were less likely to experience these events than those located at bifurcations (odds ratio, 0.07; 95% CI, 0.01–0.51).

Conclusions—

The Derivo Embolization Device is a safe and effective treatment for intracranial aneurysms.

Clinical Trial Registration—

URL:
http://plataformabrasil.saude.gov.br/login.jsf
. Unique identifier: CAAE 77089717.7.1001.5125.
Uncovering Neotropical treefrog diversity: integrative taxonomy reveal paraphyly in Boana atlantica (Amphibia, Anura, Hylidae)
Authors: Lima Luana Rodrigues , Dubeux Marcos Jorge Matias , do Nascimento Filipe Augusto Cavalcanti , Bruschi Daniel Pacheco , Mott Tamí
Published: July 2019

Boana atlantica was described based on morphological characters to acommodate populations from Bahia state, Brazil, previously referred to as B. punctata. However, its taxonomic validity is questionable due to inconsistencies in bioacoustic data. Here, we integrate molecular, cytogenetic and morphological data to re-evaluate the taxonomic status of B. atlantica. Molecular analyses provided strong support for the hypothesis that B. atlantica is a valid species, being, however, nominal populations from Bahia state paraphyletic with respect to individuals of B. atlantica collected in Alagoas and Pernambuco states. These populations shown high genetic divergence in the 16S rRNA mitochondrial fragment, and we consider populations from Alagoas and Pernambuco as a putative new candidate species of Boana punctata group. The external and internal morphology of the tadpoles of these lineages were similar, but Nucleolar Organizer Regions (NOR) was sited in different chromosomes. Our results indicate that B. atlantica is paraphyletic and may be a complex of species. Morphological of adult and/or bioacoustical data should be further assessed to find diagnostic characters to tease these lineages apart and name them properly.
Morphological and molecular evidence of Turkish Minuartiella species (Caryophyllaceae), with a desciption of a new species and a proposal for a new combination
Authors: KOÇ MURAT , HAMZAOĞLU ERGIN , AKSOY AHMET
Published: July 2019

The genus Minuartiella comprises four species distributed in the E-Mediterranean region and SW-Asia. Some interesting specimens belonging to the genus where collected from Burdur province (Turkey). On the basis of macro- and micromprhological analyses, as well as molecular data, a new species—Minuartiella serpentinicola sp. nov.—and a new combination—Minuartiella ×antalyensis comb. nov.—are proposed in the present paper. A detailed description of the new species as well as pictures, distribution map, habitat, and IUCN category are also provided. A diagnostic key of Mnuartiella species is provided.
Micarea fennica, a new lignicolous lichen species from Finland
Authors: LAUNIS ANNINA , MYLLYS LEENA
Published: July 2019

A new species Micarea fennica is described based on phenotypic and molecular features. The species is characterized by a pale olive green, bright green or greyish green minutely granular thallus composed of goniocysts, and stalked pycnidia that are dark grey to dark brown with Sedifolia-grey pigment in the wall structures (K+ violet, C+ violet), 0.2–0.5(–1) mm tall and covered by a thin white tomentum. The species produces micareic acid. Micarea fennica is similar to M. hedlundii and M. botryoides, but differs by having a paler granular thallus, stalked dark grey to dark brown pycnidia covered by a thin white tomentum and the production of micareic acid. The new species occupies soft lignum of late decay stages and is probably rare.
Caddisflies of Mongolia: Distribution and diversity
Authors: CHULUUNBAT SUVDTSETSEG , MORSE JOHN C. , BOLDBAATAR SOSORBURAM
Published: July 2019

In Mongolia, there are 198 caddisfly species belonging to 69 genera in 16 families. An updated species list also indicates the species that have been DNA barcoded. The distributions of species in the Mongolian aimags (provinces) are presented. Most species records are results from the Mongolian Aquatic Insect Survey (2002–2011, northcentral and western Mongolia) and Hovsgol_GEF projects (2002–2006, Lake Hovsgol and vicinity), and personal collections; other records are from the literature. The Mongolian caddisfly fauna is characteristic of central Asia and includes only 1 endemic species. Over half of the known Mongolian species occur in Hovsgol Aimag.
Mesozoic Trichoptera with reduced venation
Authors: SUKATSHEVA IRINA D. , VASSILENKO DMITRY V.
Published: July 2019

The reduction of fore-wing venation by Mesozoic Trichoptera presumably occurred in two directions. The first, traditional direction was related to the decrease in size of their bodies, and it has been recorded for Trichoptera found in Cretaceous fossil resins. These insects are very small, they have a strongly reduced venation, which is more typical for Cenozoic or recent caddisflies than for the Cretaceous ones. Botosaneanu & Wichard (1983) described the family Taymyrelectronidae from Cretaceous resins from the Taymyr Peninsula, whose representatives had a common area free of any veins in their forewings other than DC, MC, and TC cells. The second direction is typical for primitive Trichoptera and does not concern the size of their bodies. Starting with the beginning of the Mesozoic, the Triassic and the Lower Jurassic, certain changes in the caddisflies’ morphology were noted. Thus, the reduction of veins occurred by their merging, desclerotization, disappearance, and formation of strange large bullas on R. The reduction occurred by the merging of veins, or their desclerotization or disappearance (e.g., loss of forks F1 and F4 in Dysoneuridae Sukatsheva 1968 and Baissoferidae Sukatsheva 1968). Among recent caddisflies, the Kokiriidae McFarlane 1964 are close to the Mesozoic ones because they do not have forks F1 and F4 in their forewings.
Project overview: the Drusinae (Insecta, Trichoptera) in a World of global change—bridging basic and applied research in a highly sensitive aquatic insect group

Authors: WARINGER JOHANN , GRAF WOLFRAM , BÁLINT MIKLÓS , KUČINIĆ MLADEN , PAULS STEFFEN U. , PREVIŠIĆ ANA , KERESZTES LUJZA , VITECEK SIMON
Published: July 2019

This paper summarizes the layout, the three work packages (WP) and the preliminary (November 2014) as well as intended outcomes of the Drusinae project funded by the Austrian Science Fund (FWF).