bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic nomogram to predict the overall survival of patients with early-onset colorectal cancer: a population-based analysis
Authors: Wu Junxian , Lu Linbin , Chen Hong , Lin Yihong , Zhang Huanlin , Chen Enlin , Lin Weiwei , Li Jie , Chen Xi
Published: July 2021

Purpose

The present study aimed to identify independent clinicopathological and socio-economic prognostic factors associated with overall survival of early-onset colorectal cancer (EO-CRC) patients and then establish and validate a prognostic nomogram for patients with EO-CRC.

Methods

Eligible patients with EO-CRC diagnosed from 2010 to 2017 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided into a training cohort and a testing cohort. Independent prognostic factors were obtained using univariate and multivariate Cox analyses and were used to establish a nomogram for predicting 3- and 5-year overall survival (OS). The discriminative ability and calibration of the nomogram were assessed using C-index values, AUC values, and calibration plots.

Results

In total, 5585 patients with EO-CRC were involved in the study. Based on the univariate and multivariate analyses, 15 independent prognostic factors were assembled into the nomogram to predict 3- and 5-year OS. The nomogram showed favorable discriminatory ability as indicated by the C-index (0.840, 95% CI 0.827–0.850), and the 3- and 5-year AUC values (0.868 and 0.84869 respectively). Calibration plots indicated optimal agreement between the nomogram-predicted survival and the actual observed survival. The results remained reproducible in the testing cohort. The C-index of the nomogram was higher than that of the TNM staging system (0.840 vs 0.804, P < 0.001).

Conclusion

A novel prognostic nomogram for EO-CRC patients based on independent clinicopathological and socio-economic factors was developed, which was superior to the TNM staging system. The nomogram could facilitate postoperative individual prognosis prediction and clinical decision-making.
Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma
Authors: Ayakannu Thangesweran , Taylor Anthony H. , Konje Justin C.
Published: July 2021

Although the expression of the putative cannabinoid receptor GPR55 has been shown to be involved in the growth of various tumours and is increased in a number of cancers, its expression has not been examined in patients with endometrial cancer (EC). Quantitative RT-PCR (for mRNA levels) and immunohistochemistry (for protein levels) were used to measure GPR55 expression in patients with Type 1 and Type 2 EC and correlated against cannabinoid receptor (CB1 and CB2) protein levels using non-cancerous endometrium as the control tissue. The data indicated that GPR55 transcript and GPR55 protein levels were significantly (p < 0.002 and p < 0.0001, respectively) higher in EC tissues than in control tissues. The levels of immunoreactive GPR55 protein were correlated with GPR55 transcript levels, but not with the expression of CB1 receptor protein, and were inversely correlated with CB2 protein expression, which was significantly decreased. It can be concluded that GPR55 expression is elevated in women with EC, and thus could provide a potential novel biomarker and therapeutic target for this disease.
Preference between medical outcomes and travel times: an analysis of liver transplantation
Authors: Burkamp Jasper Richard , Bühn Stefanie , Schnitzbauer Andreas , Pieper Dawid
Published: July 2021

Background

There is evidence of a volume outcome relationship for liver transplantation. In Germany, there is a minimum volume threshold of 20 transplantations per year for each center. Thresholds potentially lead to centralization of the healthcare supply, generating longer travel times.

Objective

This study assessed whether patients are willing to travel longer times to transplantation centers for better outcomes (lower hospital mortality and higher 3-year survival) and identified patient characteristics influencing their choices.

Methods

Participants were recruited in hospitals and via random samples at registration offices. Discrete choice experiments were used to identify trade-offs in their choices between local and regional centers. Descriptive statistics and logistic regression models were used to measure patients’ preferences and quantify potentially influencing characteristics.

Results

Overall, 82.22% (in-hospital mortality) and 84.44% (3-year survival) of the participants opted to accept a longer travel time in order to receive a liver transplantation with better outcomes.

Conclusion

Most participants were willing to trade shorter travel times for lower mortality risks and higher 3-year survival in cases of liver transplantation.
GOALIATH: a theory of goal-directed behavior
Authors: Hommel Bernhard
Published: July 2021

Commonsense and theorizing about action control agree in assuming that human behavior is (mainly) driven by goals, but no mechanistic theory of what goals are, where they come from, and how they impact action selection is available. Here I develop such a theory that is based on the assumption that GOALs guide Intentional Actions THrough criteria (GOALIATH). The theory is intended to be minimalist and parsimonious with respect to its assumptions, as transparent and mechanistic as possible, and it is based on representational assumptions provided by the Theory of Event Coding (TEC). It holds that goal-directed behavior is guided by selection criteria that activate and create competition between event files that contain action-effect codes matching one or more of the criteria—a competition that eventually settles into a solution favoring the best-matching event file. The criteria are associated with various sources, including biological drives, acquired needs (e.g., of achievement, power, or affiliation), and short-term, sometimes arbitrary, instructed aims. Action selection is, thus, a compromise that tries to satisfy various criteria related to different driving forces, which are also likely to vary in strength over time. Hence, what looks like goal-directed action emerges from, and represents an attempt to satisfy multiple constraints with different origins, purposes, operational characteristics, and timescales—which among other things does not guarantee a high degree of coherence or rationality of the eventual outcome. GOALIATH calls for a radical break with conventional theorizing about the control of goal-directed behavior, as it among other things questions existing cognitive-control theories and dual-route models of action control.
Using company-specific headlines and convolutional neural networks to predict stock fluctuations
Authors: Readshaw Jonathan , Giani Stefano
Published: July 2021

This work presents a convolutional neural network for the prediction of next-day stock fluctuations using company-specific news headlines. Experiments to evaluate model performance using various configurations of word embeddings and convolutional filter widths are reported. The total number of convolutional filters used is far fewer than is common, reducing the dimensionality of the task without loss of accuracy. Furthermore, multiple hidden layers with decreasing dimensionality are employed. A classification accuracy of 61.7% is achieved using pre-learned embeddings, that are fine-tuned during training to represent the specific context of this task. Multiple filter widths are also implemented to detect different length phrases that are key for classification. Trading simulations are conducted using the presented classification results. Initial investments are more than tripled over an 838-day testing period using the optimal classification configuration and a simple trading strategy. Two novel methods are presented to reduce the risk of the trading simulations. Adjustment of the sigmoid class threshold and re-labelling headlines using multiple classes form the basis of these methods. A combination of these approaches is found to be more than double the Average Trade Profit achieved during baseline simulations.
Laser Spectroscopy Measurements of Metastable Pionic Helium Atoms at Paul Scherrer Institute
Authors: Hori M. , Aghai-Khozani H. , Sótér A. , Dax A. , Barna D.
Published: July 2021

We review recent experiments carried out by the PiHe collaboration of the Paul Scherrer Institute (PSI) that observed an infrared transition of three-body pionic helium atoms by laser spectroscopy. These measurements may lead to a precise determination of the charged pion mass, and complement experiments of antiprotonic helium atoms carried out at the new ELENA facility of CERN.
Effects of habitat conditions on the boldness and sociability of wild-caught fish (Zacco platypus) along a river
Authors: Tang Zhonghua , Fu Shi-Jian
Published: July 2021

Wild fish show consistent behavioral differences, e.g., personalities among populations, whereas the possible relationships between personality and environmental conditions have seldom been systemically examined. We aimed to test whether the personality of wild-caught fish was affected by the biotic (food resources and predation) and abiotic (temperature, dissolved oxygen level, and flow velocity) conditions of natural habitats. Six populations of pale chub (Zacco platypus) were sampled along a river longer than 1000 km, and environmental conditions and personality characteristics, such as boldness, activity, and sociability, were measured. Personality variables could be reduced to two factors by principal component analysis, boldness, and sociability factors, with the former factor having more variation among and within populations. Individuals from populations with higher food availability (plankton density) and flow velocity generally showed higher boldness factor scores, possibly due to the better energy status of higher food abundance or the low water transparency and hence decreased predation risk and fast-flow lifestyle of populations with higher water velocity populations. All populations showed high sociability as group-living species, which was positively correlated with only the phytoplankton biomass, possibly due to decreased intraspecific competition in habitats with abundant food resources. The correlations among personality variables were population-dependent, as individuals who moved more had a shorter distance to the stimulus shoal (i.e., increased shoaling tendency) within high-predation populations, whereas individuals who moved more spent less time in shoals within low-predation populations. The results suggest that alterations in habitat conditions can result in divergent natural selection that favors a particular personality; thus, human-induced alterations in habitat conditions may shape the personality of individual fish.
Early Atherosclerotic Changes in Coronary Arteries are Associated with Endothelium Shear Stress Contraction/Expansion Variability
Authors: Mazzi Valentina , De Nisco Giuseppe , Hoogendoorn Ayla , Calò Karol , Chiastra Claudio , Gallo Diego , Steinman David A. , Wentzel Jolanda J. , Morbiducci Umberto
Published: July 2021

Although unphysiological wall shear stress (WSS) has become the consensus hemodynamic mechanism for coronary atherosclerosis, the complex biomechanical stimulus affecting atherosclerosis evolution is still undetermined. This has motivated the interest on the contraction/expansion action exerted by WSS on the endothelium, obtained through the WSS topological skeleton analysis. This study tests the ability of this WSS feature, alone or combined with WSS magnitude, to predict coronary wall thickness (WT) longitudinal changes. Nine coronary arteries of hypercholesterolemic minipigs underwent imaging with local WT measurement at three time points: baseline (T1), after 5.6 ± 0.9 (T2), and 7.6 ± 2.5 (T3) months. Individualized computational hemodynamic simulations were performed at T1 and T2. The variability of the WSS contraction/expansion action along the cardiac cycle was quantified using the WSS topological shear variation index (TSVI). Alone or combined, high TSVI and low WSS significantly co-localized with high WT at the same time points and were significant predictors of thickening at later time points. TSVI and WSS magnitude values in a physiological range appeared to play an atheroprotective role. Both the variability of the WSS contraction/expansion action and WSS magnitude, accounting for different hemodynamic effects on the endothelium, (1) are linked to WT changes and (2) concur to identify WSS features leading to coronary atherosclerosis.
Application of supported lanthanum catalysts in the hydrogenation of nitriles
Authors: Juhász Kinga , Lévay Krisztina , Hegedűs László , Balogh-Weiser Diána , Pirault-Roy Laurence , Hell Zoltán
Published: July 2021

Nickel and lanthanum on MgO or MgO–Al2O3catalysts were prepared and characterized. The applicability of the catalysts was studied in the liquid-phase hydrogenation of benzonitrile. A La/MgO catalyst showed surprisingly high activity and selectivity. The scope of the reaction was extended to other nitriles (benzyl cyanide, cinnamonitrile, adiponitrile) over this La/MgO catalyst.
Do prior knowledge, model-observer similarity and social comparison influence the effectiveness of eye movement modeling examples for supporting multimedia learning?
Authors: Krebs Marie-Christin , Schüler Anne , Scheiter Katharina
Published: July 2021

We investigated in an experiment with 180 university students the joint role of prior knowledge, alleged model competence, and social comparison orientation regarding the effectiveness of Eye Movement Modeling Examples (EMME) for supporting multimedia learning. EMME consisted of short videos with gaze replays of an instructed model demonstrating effective multimedia processing strategies. Participants were either instructed that the model in the EMME-videos was a successful learner (competent model) or another participant (peer model). Participants in a control condition received no EMME. Furthermore, we activated domain-relevant prior knowledge in half of the participants before watching the EMME. Against our expectations, we found no influence of either prior knowledge activation or model-observer similarity. As expected, our results indicated that EMME fostered multimedia learning. This was also supported by findings from small-scale meta-analyses that were conducted with the focus on the effect of EMME for multimedia learning and potential moderators of the effect. Moreover, results showed first evidence that social comparison orientation interacts with (alleged) model competence regarding the effectiveness of EMME. Further research is needed to follow up on the influence of individual factors as well as social cues on the effectiveness of EMME.
Burnout in Surgical Trainees: a Narrative Review of Trends, Contributors, Consequences and Possible Interventions
Authors: Johnson Judith , Al-Ghunaim Tmam Abdulaziz , Biyani Chandra Shekhar , Montgomery Anthony , Morley Roland , O’Connor Daryl B.
Published: July 2021

Surgical disciplines are popular and training places are competitive to obtain, but trainees report higher levels of burnout than either their non-surgical peers or attending or consultant surgeons. In this review, we critically summarise evidence on trends and changes in burnout over the past decade, contributors to surgical trainee burnout, the personal and professional consequences of burnout and consider the evidence for interventions. There is no evidence for a linear increase in burnout levels in surgeons over the past decade but the impact of the COVID-19 pandemic has yet to be established and is likely to be significant. Working long hours and experiencing stressful interpersonal interactions at work are associated with higher burnout in trainees but feeling more supported by training programmes and receiving workplace supervision are associated with reduced burnout. Burnout is associated with poorer overall mental and physical well-being in surgical trainees and has also been linked with the delivery of less safe patient care in this group. Useful interventions could include mentorship and improving work conditions, but there is a need for more and higher quality studies.
Incidence of Acute Kidney Injury Is Lower in High-Risk Patients Undergoing Percutaneous Coronary Intervention Supported with Impella Compared to ECMO
Authors: Schweitzer Julian , Horn Patrick , Voss Fabian , Kivel Milena , Wolff Georg , Jung Christian , Zeus Tobias , Kelm Malte , Westenfeld Ralf
Published: July 2021

Acute kidney injury (AKI) is a common complication post-PCI. Here, in a single-center observational registry, we compared the frequency of AKI in patients at elevated risk for AKI (based on Mehran risk stratification scoring) who underwent VA-ECMO- or Impella-supported high-risk PCI. A total of 28 patients scheduled for elective high-risk PCI with mechanical circulatory support were studied prospectively. All patients were turned down for surgery due to exceedingly high risk. Allocation to VA-ECMO (n=11) or Impella (n=17) was performed according to site-specific restrictions on the daily availability of the VA-ECMO platform as a prospective enrollment and performed prior to initiation of PCI. We analyzed AKI incidence as our primary endpoint, as well as PCI success, duration, and peripheral complications. All patients were successfully revascularized and had MCS weaned at the end of the procedure. Baseline GFR and procedural contrast media were similar. Despite similar risks for AKI as calculated by the Mehran score (35 ± 18.9 vs. 31 ± 16.6 %; p=0.55), patients supported by Impella during PCI demonstrated a reduced incidence of AKI (55 vs. 12 %; p=0.03). MCS-assisted high-risk PCI with VA-ECMO or Impella is feasible. However, Impella is associated with a shorter procedure time and a lower incidence of AKI.
A New Era Is Beginning in Central and Eastern Europe: Information and Communication Technology Services Exceed Manufacturing in the Global Production Chain
Authors: Cieślik Ewa
Published: July 2021

The article compares changes in tendencies of value-added flows and the places held by the Central and Eastern European economies (11 countries: Visegrad countries, Baltic States, Slovenia, Bulgaria, Croatia, and Romania; CEE) in global value chains (GVCs) in manufacturing, services, and their subgroup—information and telecommunication (ICT) services, by relying on the trade in value-added data retrieved from the OECD’s Inter-Country Input–Output Database, available over the period 2005–2015. The objective of this study is to understand the role of these economies in international production linkages applying a value-added methodology. Therefore, the study discusses the role of CEE economies in global economy in terms of forms of participation of services, especially ICT services, in GVCs, including the process of “servicification” of manufacturing. This study led to the verification of two hypotheses: (1) the position of manufacturing in GVCs has been steadily weakening and (2) services, especially ICT services, can have a positive effect on participation of CEE economies in GVCs. The first hypothesis was confirmed by most of analysed countries. The other research question turned out not to be true for all CEE countries, but most of them proved this hypothesis.
Structure-sensitive testimonial norms
Authors: Höltgen Benedikt T. A.
Published: July 2021

Although there has been a lot of investigation into the influence of the network structure of scientific communities on the one hand and into testimonial norms (TNs) on the other, a discussion of TNs that take the network structure into account has been lacking. In this paper, I introduce two TNs which are sensitive to the local network structure. According to these norms, scientists should give less weight to the results of well-connected colleagues, as compared to less connected ones. I employ an Agent Based Model to test the reliability of the two novel TNs against different versions of conventional, structure-insensitive TNs in networks of varying size and structure. The results of the simulations show that the novel TNs are more reliable. This suggests that it would be beneficial for scientific communities if their members followed such norms. For individual scientists, I show that there are both reasons for and reasons against adopting them.
Pleural Manometry—Basics for Clinical Practice
Authors: Faber Katarzyna , Krenke Rafal
Published: July 2021

Purpose of Review

The aim of this paper is to present basic data on pleural manometry and to outline the advances in its use as both a research tool enabling a better understanding of pleural pathophysiology and as a clinical tool useful in management strategy planning in patients with pleural diseases. To discuss updates and current trends in the development of pleural manometry, a search of the literature on pleural manometry published in recent years was performed.

Recent Findings

The technique of pleural manometry has significantly evolved over the last 40 years from simple water manometers to electronic or digital devices which enable the measurement and recording of instantaneous pleural pressure. Although to date it is mainly used as a research tool, pleural manometry has the potential to be applied in clinical practice. Recent studies demonstrated that monitoring of pleural pressure changes during therapeutic thoracentesis does not seem to be helpful in predicting re-expansion pulmonary edema and procedure-related chest discomfort. On the other hand, measurement of pleural elastance plays an important role in the diagnosis of unexpandable lung in patients with malignant pleural effusion facilitating determination of the optimal management strategy. Additionally, it allows for study of newly discovered phenomena, including pleural pressure pulse assessment and the impact of continuous positive airway pressure and cough on pleural pressure.

Pleural manometry is an established technique of pleural pressure measurement. Despite recent advances, its role in clinical practice remains undetermined.
The Rise of ‘Group Solution’ in Insolvency Law and Bank Resolution
Authors: Kokorin Ilya
Published: July 2021

This article traces the emergence of the concept of ‘group solution’ and its manifestations in insolvency law and bank resolution as an alternative to the rigid entity-by-entity approach. The rise of this concept can be linked to the recognition of the specificity of problems related to the insolvency of multinational enterprise groups, arising from group operational and financial interconnectedness. This has not happened at once, but has resulted from the evolution of views and ideas, evident in hard and soft law instruments of the 2000s and the 2010s. In light of this important development the article explores the concept of a group solution, its rationale, scope of application and limitations. It concludes that despite the gradual acceptance of the group phenomenon, a group solution has not been formed as a coherent and well-defined legal principle. Instead, it represents a variety of approaches, tools and practices, which pursue different policy objectives underpinned by different societal values. Among them are asset value maximization, business rescue, the protection of financial stability and the preservation of banks’ critical functions. With all its flexibility, a group solution has one pervasive limitation—it cannot trump the interests of individual group members and their creditors. At the same time, in order to realize the full potential of a group solution, it is necessary to embrace the group-sensitive and forward-looking interpretation of creditors’ interest, facilitating commercially sensible and practical group solutions.
Parameters Affecting the Precipitation of Al Phases from Aluminate Solutions of the Pedersen Process: The Effect of Carbonate Content
Authors: Marinos Danai , Vafeias Michail , Sparis Dimitris , Kotsanis Dimitris , Balomenos Efthymios , Panias Dimitris
Published: July 2021

Leaching experiments were performed in calcium aluminate slag with a high-sodium carbonate adaptation of the Pedersen process. A theoretical thermodynamic study of the pregnant leaching solution was conducted to specify the thermodynamically favored species that exist within. Using the HSC 9.0 software, a carbonation process simulation (neutralization of the aluminate solution with CO2 gas) was simulated. Laboratory carbonation experiments were conducted to verify the theoretical predictions. According to the thermodynamic study, at temperatures below 50 °C gibbsite precipitates in the first stages of carbonation and then is transformed to dawsonite. Temperatures over 65 °C favor the direct precipitation of dawsonite. The same route (thermodynamic analysis, carbonation simulation, and experimental verification) was followed by a synthetic solution containing lower amount of sodium carbonate to prove that dawsonite precipitation occurred as a result of the high free carbonate content, to investigate the effect of temperature and to precipitate alumina hydrate phases.

Graphical Abstract
A retrospective cohort study of 27,049 polytraumatized patients age 60 and above: identifying changes over 16 years
Authors: Kalbas Y. , Lempert M. , Ziegenhain F. , Scherer J. , Neuhaus V. , Lefering R. , Teuben M. , Sprengel K. , Pape H. C. , Jensen Kai Oliver ,   The TraumaRegister DGU
Published: July 2021

Purpose

The number of severely injured patients exceeding the age of 60 has shown a steep increase within the last decades. These patients present with numerous co-morbidities, polypharmacy, and increased frailty requiring an adjusted treatment approach. In this study, we establish an overview of changes we observed in demographics of older severe trauma patients from 2002 to 2017.

Methods

A descriptive analysis of the data from the TraumaRegister DGU® (TR-DGU) was performed. Patients admitted to a level one trauma center in Germany, Austria and Switzerland between 2002 and 2017, aged 60 years or older and with an injury severity score (ISS) over 15 were included. Patients were stratified into subgroups based on the admission: 2002–2005 (1), 2006–2009 (2), 2010–2013 (3) and 2014–2017 (4). Trauma and patient characteristics, diagnostics, treatment and outcome were compared.

Results

In total 27,049 patients with an average age of 73.9 years met the inclusion criteria. The majority were males (64%), and the mean ISS was 27.4. The proportion of patients 60 years or older [(23% (1) to 40% (4)] rose considerably over time. Trauma mechanisms changed over time and more specifically low falls (< 3 m) rose from 17.6% (1) to 40.1% (4). Altered injury patterns were also identified. Length-of-stay decreased from 28.9 (1) to 19.5 days (4) and the length-of-stay on ICU decreased from 17.1 (1) to 12.7 days (4). Mortality decreased from 40.5% (1) to 31.8% (4).

Conclusion

Length of stay and mortality decreased despite an increase in patient age. We ascribe this observation mainly to increased use of diagnostic tools, improved treatment algorithms, and the implementation of specialized trauma centers for older patients allowing interdisciplinary care.
Physics of Dynamic Stall Vortex During Pitching Oscillation of Dynamic Airfoil
Authors: Wei Binbin , Gao Yongwei , Li Dong
Published: July 2021

Dynamic stall, which has a significant effect on the aerodynamic performances of dynamic airfoils, is closely related to the physics of the dynamic stall vortex (DSV). The physics of the DSV on the NACA 0012 airfoil was experimentally studied using unsteady pressure measurements with high time accuracy. The experimental Reynolds number was Re = 1.5 × 106, and the reduced frequency was k = 0.069. The propagation of the unsteady pressure field during the dynamic stall process was analyzed in detail. The motion characteristics of the DSV were examined, including its near-wall development characteristics and near-wall evolution velocity. Moreover, the frequency characteristics of the near-wall DSV were studied using wavelet analysis combined with proper orthogonal decomposition (POD) technology. In addition, the effects of the mean angle of attack (AoA) and the amplitude on the DSV motion and frequency characteristics were examined in detail. The effects of the mean AoA on the near-wall DSV strength and the propagation velocity were linear, while the effects of amplitude were nonlinear. The mean AoA and amplitude had a significant influence on the frequency of the leading-edge vortex (LEV) at the initial stage of the DSV development (x/c = 0.10–0.20). This work allows the DSV physics to be understood more deeply.

Graphic abstract
Massive Tick Bites Causing Spotted Fever Rickettsial Infection: A Hazard in a Tea Plantation, Sri Lanka
Authors: Warnasooriya Sithara , Kularatne Damsara , Kularatne Sathya , Weerakoon Kosala
Published: July 2021

Tea plantations in Sri Lanka cover the central hills of the island, where spotted fever group (SFG) rickettsial infection is common. In most cases, the history of tick bite is obscure and eschars are not present. A 45-y-old female experienced massive tick bites while working in her tea plantation. She developed fever 2 d after exposure, but the diagnosis of SFG infection was not considered until a skin rash appeared on the eighth day. She had a very high titer of antirickettsial antibodies detected by immunofluorescence assay and responded to doxycycline. Here, we highlight the high risk of exposure to ticks and tick bites within tea estates and its causal relationship to SFG infection, which is increasing in Sri Lanka. Active case detection, notification, surveillance, and community awareness are imperative. Possible preventative measures for tick bites have to be introduced. There is a need to explore the effectiveness of local remedies currently in use.
Europe and the Anglo-Saxons
Authors: Tinti Francesca
Published: July 2021

This publication explores the interactions between the inhabitants of early medieval England and their contemporaries in continental Europe. Starting with a brief excursus on previous treatments of the topic, the discussion then focuses on Anglo-Saxon geographical perceptions and representations of Europe and of Britain's place in it, before moving on to explore relations with Rome, dynasties and diplomacy, religious missions and monasticism, travel, trade and warfare. This Element demonstrates that the Anglo-Saxons' relations with the continent had a major impact on the shaping of their political, economic, religious and cultural life.
Subpial Thorn-shaped Astrocytes Are Prevalent In Guam ALS/PDC
Authors: Kovacs G.G. , Robinson J.L. , Perl D.P. , Lee V.M.Y. , Trojanowski J.Q.
Published: July 2021

Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex is a progressive neurodegenerative disorder characterized by neuronal and glial tau pathologies. With the aim to evaluate aging-related tau astrogliopathy (ARTAG) we examined the collection at the University of Pennsylvania, consisting of blocks of the frontal parietal, temporal, and occipital cortices. Formalin fixed, paraffin-embedded tissue blocks were evaluated using anti-tau antibodies PHF-1 and AT8. In addition to neuronal and oligodendroglial tau pathology, granular/fuzzy astrocytes in the gray matter and thorn-shaped astrocytes (TSAs) in subpial location were also observed. Twenty-one out of 33 cases (63%) showed subpial TSAs diffusely along the cortical surface in one or more cortical regions. Accumulation of TSAs in the depth of the sulci were seen in 41% in the temporal, 7% in the frontal and 14% in parietal cortex. This was not associated with perivascular neuronal tau pathology in the depth of the sulci. Accumulation of TSAs in the depth of cortical sulci in this cohort is approximately 20 times more frequent than reported in a European aging cohort. The presence of subpial TSAs in the depth of cortical sulci in CTE and Guam PDC, and less frequently in aging brains, might suggest common mechanisms.

Learning Objectives

Describe the spectrum of neuropathology in Guam ALS/PDC

Describe the frequency of tau positive cortical subpial thorn-shaped astrocytes
Effects of dietary tryptophan on muscle growth, protein synthesis and antioxidant capacity in hybrid catfish Pelteobagrus vachelli♀ × Leiocassis longirostris♂
Authors: Jiang Qin , Zhao Ye , Zhou Xiao-Qiu , Wu Xiao-Yun , Xu Shang-Xiao , Feng Lin , Liu Yang , Jiang Wei-Dan , Wu Pei , Zhao Juan , Jiang Jun
Published: July 2021

The present study evaluated effects of dietary supplementation with tryptophan (Trp) on muscle growth, protein synthesis and antioxidant capacity in hybrid catfish Pelteobagrus vachelli♀ × Leiocassis longirostris♂. Fish were fed six different diets containing 2·6 (control), 3·1, 3·7, 4·2, 4·7 and 5·6 g Trp/kg diet for 56 d, respectively. Results showed that dietary Trp significantly (1) improved muscle protein content, fibre density and frequency of fibre diameter; (2) up-regulated the mRNA levels of PCNA, myf5, MyoD1, MyoG, MRF4, IGF-I, IGF-II, IGF-IR, PIK3Ca, TOR, 4EBP1 and S6K1; (3) increased phosphorylation levels of AKT, TOR and S6K1; (4) decreased contents of MDA and PC, and increased activities of CAT, GST, GR, ASA and AHR; (5) up-regulated mRNA levels of CuZnSOD, CAT, GST, GPx, GCLC and Nrf2, and decreased Keap1 mRNA level; (6) increased nuclear Nrf2 protein level and the intranuclear antioxidant response element-binding ability, and reduced Keap1 protein level. These results indicated that dietary Trp improved muscle growth, protein synthesis as well as antioxidant capacity, which might be partly related to myogenic regulatory factors, IGF/PIK3Ca/AKT/TOR and Keap1/Nrf2 signalling pathways. Finally, based on the quadratic regression analysis of muscle protein and MDA contents, the optimal Trp requirements of hybrid catfish (21·82–39·64 g) were estimated to be 3·94 and 3·93 g Trp/kg diet (9·57 and 9·54 g/kg of dietary protein), respectively.
Defining Manhood: Monastic Masculinity and Effeminacy in Contemporary Thai Buddhism
Authors: Chladek Michael R.
Published: July 2021

The study of Theravada Buddhism and gender has often focused on the relationship between men's and women's roles, particularly their differing ability to become fully ordained monks. Yet in Thailand, as in many parts of the world, gender is more complicated than the binary of just men and women. Scholars have noted that what it means to be a man in Thailand is often defined in terms of not being effeminate, gay, or transgender. Drawing on Thai news stories, social media comments, and ethnographic research, I explore how monastic masculinity—the way in which what it means to be an ideal monk informs notions of being an ideal man—is constructed through the assertion that effeminate gay orkathoei(transgender) individuals cannot and should not be ordained. Taking into account such broader social constructions of gender and sexuality is important to better understand the relationship between masculinity and Buddhist monasticism.
The perspectives of successful ageing among older adults aged 75+: a systematic review with a narrative synthesis of mixed studies
Authors: Badache Andreea C. , Hachem Hany , Mäki-Torkko Elina
Published: July 2021

Older adults 75 and above are a fast-growing segment of the population. However, few studies have investigated what it means to age successfully from their perspective. This group of older adults face challenges that might characteristically differ from younger older adults. Therefore, the aim of this study was to conduct a systematic review of the perspectives of older adults aged 75 and above regarding what it means to age successfully and to summarise the findings through a narrative synthesis. We also aimed to provide a snapshot of inhibitors and facilitators to achieve successful ageing. A systematic review of the 75+ older adults’ perspectives was conducted across PubMed, CINAHL, Scopus, Web of Science and PsycINFO. Qualitative, quantitative and mixed-methods original peer-reviewed studies were included. After reviewing 4,661 articles, 15 articles met the inclusion criteria and 15 themes were identified. They ranged from biomedical components such as physical functioning to psychosocial components such as relationships, reflections on life and past experiences, preparations for death and environmental factors. The findings revealed that as people age, their definition of successful ageing changes, expanding the current conceptualisation of successful ageing by including additional factors that can act as facilitators and/or inhibitors, such as death and environmental factors. The findings also highlight the need for further research on theory development by considering age-related differences and the perspectives of under-studied populations.
A lattice approach for option pricing under a regime-switching GARCH-jump model
Authors: Guo Zhiyu , Bai Yizhou
Published: July 2021

In this study, we consider option pricing under a Markov regime-switching GARCH-jump (RS-GARCH-jump) model. More specifically, we derive the risk neutral dynamics and propose a lattice algorithm to price European and American options in this framework. We also provide a method of parameter estimation in our RS-GARCH-jump setting using historical data on the underlying time series. To measure the pricing performance of the proposed algorithm, we investigate the convergence of the tree-based results to the true option values and show that this algorithm exhibits good convergence. By comparing the pricing results of RS-GARCH-jump model with regime-switching GARCH (RS-GARCH) model, GARCH-jump model, GARCH model, Black–Scholes (BS) model, and Regime-Switching (RS) model, we show that accommodating jump effect and regime switching substantially changes the option prices. The empirical results also show that the RS-GARCH-jump model performs well in explaining option prices and confirm the importance of allowing for both jump components and regime switching.
Potentially Inappropriate Medication Use in the Elderly
Authors: Charles Lesley , Kumar Elena , Elghol Eimad , Dobbs Bonnie , Tian Peter George Jaminal , Babenko Oksana
Published: July 2021

It is estimated that approximately half of adults, older than 65 years of age, have been prescribed potentially inappropriate medications (PIMs). This study’s objective was to determine the prevalence of PIM use among older patients. Two retrospective chart reviews were performed on 200 and 164 older patients who underwent comprehensive geriatric assessments (CGAs) at outpatient geriatrics clinics at the Glenrose Rehabilitation Hospital (Glenrose) in 2012–13 and at the Misericordia Community Hospital (Misericordia) in 2016–17, respectively. Outcome measures included demographics; prevalence of PIM use; common PIMs used; whether PIM use was addressed, and if so, how; and total number of oral medications. At the Glenrose, the prevalence of PIM use was 45 per cent (90/200). Of the 90 patients who had used PIMs, 46.7 per cent (42/90) had at least one of their medications stopped or modified. At the Misericordia, the prevalence of PIM use was 57.3 per cent (94/164). Of the 94 patients who used PIMs, 47.9 per cent (45/94) had at least one of their medications stopped or modified. These results suggest that an increased awareness of PIM among physicians is needed to further decrease PIM use.
Electrophysiological effects and clinical utility of propafenone in children
Authors: Singh Manavotam , McKenzie Keore , Hudak Mark L. , Gehi Anil K. , Ferns Sunita J.
Published: July 2021

Aim:

This retrospective case series study sought to describe the safety and clinical effectiveness of propafenone for the control of arrhythmias in children with and without CHD or cardiomyopathy.

Methods:

We reviewed baseline characteristics and subsequent outcomes in a group of 63 children treated with propafenone at 2 sites over a 15-year period Therapy was considered effective if no clinically apparent breakthrough episodes of arrhythmias were noted on the medication.

Results:

Sixty-three patients (29 males) were initiated on propafenone at a median age of 2.3 years. CHD or cardiomyopathy was noted in 21/63 (33%). There were no significant differences between demographics, clinical backgrounds, antiarrhythmic details, side effect profiles, and outcomes between children with normal hearts and children with CHD or cardiomyopathy. Cardiac depression at the initiation of propafenone was more common amongst children with CHD or cardiomyopathy compared to children with normal hearts. Systemic ventricular function was diminished in 15/63 patients (24%) prior to starting propafenone and improved in 8/15 (53%) of patients once better rhythm control was achieved. Other than one child in whom medication was stopped due to gastroesophageal reflux, no other child experienced significant systemic or cardiac side effects during treatment with propafenone. Propafenone achieved nearly equal success in controlling arrhythmias in both children with normal hearts and children with congenital heart disease or cardiomyopathy (90% versus 86%, p = 0.88).

Conclusion:

Propafenone is a safe and effective antiarrhythmic medication in children.
Heterotaxy: fluctuat nec mergitur
Authors: Houyel Lucile , Moreau de Bellaing Anne , Bonnet Damien
Published: July 2021

The International Pediatric and Congenital Cardiac Code (IPCCC) states thatvisceral heterotaxyis defined as “a congenital malformation in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body. By convention, in congenital cardiology, heterotaxy syndrome does not include patients with complete mirror-imaged arrangement of the internal organs along the left-right axis also known as “total mirror imagery” or “situs inversus totalis”.” [www.ipccc.net]

In patients with heterotaxy, it is important to describe both the cardiac relations and the junctional connections of the cardiac segments, with documentation of the arrangement of the atrial appendages, the ventricular topology, the nature of the unions of the segments across the atrioventricular and the ventriculoarterial junctions, the infundibular morphologies, and the relationships of the arterial trunks in space. Particular attention is required for the venoatrial connections, since these are so often abnormal. The relationship and arrangement of the remaining thoraco-abdominal organs, including the lungs, the spleen, the liver, and the intestines, also must be described separately, because, although common patterns of association have been identified, there are frequent exceptions to these common patterns. Therefore, in patients with heterotaxy, it is important to describe each thoracic and abdominal organ independently.
Stress tolerance indices for the identification of low phosphorus tolerant introgression lines derived from Oryza rufipogon Griff.
Authors: P. S. Basavaraj , C. Gireesh , Bharamappanavara Muralidhara , C. A. Manoj , V. G. Ishwarya Lakshmi , Honnappa  , V. Ajitha , P. Senguttuvel , R. M. Sundaram , M. S. Anantha
Published: July 2021

Soil phosphorus (P) deficiency is one of the major challenges for the cultivation of rice worldwide because it limits the growth and productivity of the crop. Therefore, the ability to grow in P-deficit soils is an important trait for rice cultivation. O . rufipogon Griff., a wild relative of rice, is a source of genetic variation for low phosphorus tolerance. The present study was undertaken to identify low P stress-tolerant introgression lines by analysing stress tolerance indices of 40 introgression lines of O. rufipogon. The populations were screened under low soil P and normal soil P plots for two growing seasons. Based on yield under stress and normal conditions, we computed different stress indices, including stress tolerance index (STI), tolerance index, yield reduction ratio (YR), stress susceptibility index, yield stability index (YSI), yield index, per cent yield reduction and geometric mean productivity (GMP). The studies of correlation analysis, principal component analysis and clustering revealed that STI, YSI and GMP were ideal indices for the selection of genotypes that performed well under both stress and normal conditions. Based on these indices, introgression lines (IL-24, IL-29 and IL-32) were identified as promising low P tolerant lines, which exhibited better grain yield under both stress (YS) and normal (YP) conditions. These pre-breeding lines serve as valuable genetic resources for low P tolerance in rice breeding programmes across the world.
Partisanship in the #MeToo Era
Authors: Holman Mirya R. , Kalmoe Nathan P.
Published: July 2021

Partisanship structures mass politics by shaping the votes, policy views, and political perceptions of ordinary people. Even so, substantial shifts in partisanship can occur when elites signal clear differences on a political issue and attentive citizens update their views of party reputations. Mismatched partisans who strongly care about the issue respond by changing parties in a process of “issue evolution” when writ large. Others simply update their views to match their party in a “conflict extension” process. We build on these models by integrating the largely separate research strands of party issue ownership. Using sexual misconduct as a critical case study, we argue that partisan change can occur rapidly when party elites move strategically to take ownership of an issue, thereby clarifying differences between the parties. Using a quasi-experiment, a survey experiment, and data from dozens of national surveys, we find recent, rapid shifts in party reputations on #MeToo, views of the issue, party votes, and broader party support.
Sekolah Islam (Islamic Schools) as Symbols of Indonesia's Urban Muslim Identity
Authors: Pribadi Yanwar
Published: July 2021

This article discusses the relationship between Sekolah Islam (Salafism-influenced Islamic schools) and urban middle-class Muslims. Based on ethnographic fieldwork in the City of Serang (Kota Serang), near Jakarta, this paper argues that these conservative and puritan Muslims demonstrate their Islamic identity politics through their engagement with Sekolah Islam. The analysis of in-depth interviews with and close observations of parents of students and school custodians (preachers or occasionally spiritual trainers) at several Sekolah Islam reveals that they have attempted to pursue ‘true’ Islamic identity and have claimed recognition of their identity as the most appropriate. The pursuit of a ‘true’ Islamic identity has infused Islamic identity politics, and there is an oppositional relationship between local Islamic traditions and Salafism, as seen in Sekolah Islam. The relationship between Islam and identity politics becomes intricate when it is transformed into public symbols, discourses, and practices at many Sekolah Islam. This paper shows that through their understanding and activities at Sekolah Islam, these Muslims are avid actors in the contemporary landscape of Islamic identity politics in Indonesia. By taking examples from Sekolah Islam in Indonesia, this article unveils social transformations that may also take place in the larger Muslim world.
Challenge Demands and Resilience
Authors: Kunzelmann Arian , Rigotti Thomas
Published: July 2021

Abstract. This study investigates the relationship of challenge demands (i. e., time pressure, job complexity) on employee resilience. We provide insights into potential pathways (i. e., learning, cognitive irritation) for how challenge stressors influence employee resilience. We employed a two-wave, time-lagged design to examine the influences of challenge stressors and explanatory pathways on employee resilience 2 months later. The data from 359 participants (52.1 % male) were analyzed using a Bayesian time-lagged path model. Results indicate that time pressure and job complexity are negatively related to employee resilience via cognitive irritation. In contrast, we found a positive, indirect effect of job complexity and resilience via learning. This paper contributes to existing employee resilience and stress research by highlighting the roles of learning and cognitive irritation to explain the relationships of challenge stressors on employee resilience. Moreover, the results provide us with a deeper understanding of which factors foster or drain employee resilience.