bluuebunny/crossref_metadata_2025 huggingface dataset:
School Mathematics in Kazakhstan: a Blueprint for Digital Transformation
Authors: Semenov Alexei L. , Abylkassymova Alma E. , Akhmed-Zaki Darkhan
Published: October 2024

The article discusses the problem of digital transformation of school mathematics education. Two traditions of mathematical education in Kazakhstan are considered in historical perspective: “factory” and creative, research. The key features of the current state of the school education system in Kazakhstan in the framework of the mass school system and alternative systems are considered. The system of state final and current student assessment, elements of the digital economy of education are characterized. The socio-economic and political prerequisites for the possibility of significant changes in the education system are formulated. The necessity is substantiated for the effective development of the country in the 21st century of personality qualities brought up in creative mathematical education in the context of tasks that are “not known how to solve”. It is shown that due to the use of digital technologies, in particular AI technologies, the process of transformation of the education system can be started in modern Kazakhstan. This transformation will be aimed at bringing the education system in line with the needs of the modern economy and modern society. The main components and dimensions of this process are considered. In particular, the necessary changes in the system of training and professional development of mathematics teachers and the necessary elements of continuity of this system with a comprehensive school are indicated.
Finite Time Hybrid Synchronization Control for Duplex Complex Networks via Intermittent Control
Authors: Xie Cheng-jun , Zhang Ying , Wei Qiang
Published: October 2024

This paper is devoted to the finite time internal and the external synchronization (hybrid synchronization) for complex networks by means of intermittent control. Different from most previous research achievements, the finite time synchronization include internal and the external synchronization, this article employs the intermittent control to drive the complex networks to achieve synchronization in finite time. To be specific, the internal and the external synchronization all achieve consistent synchronization in finite time by devise Lyapunov function. Finally, numerical examples are presented to illustrate the validness of theoretical results.
Green Synthesis and Characterization of 4'-Hydroxy-4-Nitro Chalcone using Grinding Techniques
Authors: Susanti VH Elfi , Ariani Sri Retno Dwi , Mulyani Sri , Utomo Suryadi Budi , Wathon Muhammad Hizbul
Published: October 2024

The challenge of developing environmentally friendly synthesis methods for biologically active compounds remains a significant focus in green chemistry. This study aimed to synthesize 4'-hydroxy-4-nitro chalcone from 4-hydroxyacetophenone and 4-nitrobenzaldehyde using a grinding technique and then characterize the synthesized compounds. The 4'-hydroxy-4-nitro chalcone was synthesized via the Claisen-Schmidt grinding method for 45 minutes at room temperature. The grinding results were extracted with chloroform. The formed crystals were tested for purity by thin-layer chromatography (TLC), and further purification was carried out by recrystallization. The synthesized chalcone was characterized using FTIR, 1H-NMR, and 13C-NMR  spectroscopy. The chalcone was also tested for antibacterial activity using the disc diffusion method against Staphylococcus aureus and Escherichia coli. The results showed that 4'-hydroxy-4-nitro chalcone could be successfully synthesized from 4-hydroxyacetophenone and 4-nitrobenzaldehyde using the grinding technique, yielding orangish-white crystals with a 70.63% yield and a melting point of 173°C. Purity was confirmed by TLC, and structural characterization was achieved through FTIR, 1H-NMR and 13C-NMR spectroscopy. Antibacterial testing revealed that the synthesized chalcone produced a clear zone diameter of 9.27 mm against S. aureus and 27.88 mm against E. coli. These results indicate that the compound has relatively strong antibacterial activity against E. coli and relatively weak activity against S. aureus. This study demonstrates the effectiveness of the green synthesis method and provides valuable insights into the antibacterial properties of 4'-hydroxy-4-nitro chalcone
Toxicity Test of Ethanol Extract Stelechocarpus Burahol (Kepel) Fruits through Brine Shrimp Toxicity Assay
Authors: Rahmawati Naili , Zakaria Zainul Amiruddin , Sani Mohd. Hijaz Mohd , - Kintoko , Jaziri A.Aziz
Published: October 2024

Pendahuluan: Stelechocarpus burahol (Kepel) merupakan tanaman yang tumbuh alami di Indonesia. Kepel termasuk dalam famili Annonaceae. Evaluasi terhadap toksisitas ekstrak tanaman ini sangat penting untuk mendukung untuk penelitian selanjutnya. Stelechocarpus burahol mengandung senyawa flavonoid, sebagai antimikroba dan kontrasepsi, selain itu flavonoid mengaktifkan jalur antioksidan yang memberikan efek antiinflamasi. Kontrasepsi yang cocok untuk pria dan wanita harus mampu mencegah pembuahan, murah, tidak memiliki efek samping, sehingga diperlukan tanaman obat alami sebagai agen kontrasepsi (KA) karena aman, murah, memiliki antioksidan, dan antiinflamasi. Brine Shrimp Toxicity Assay terhadap ekstrak etanol tanaman ini telah diuji.
Metode: Desain true eksperimen, sampel terdiri 6 kelompok, dan tiap kelompok terdiri dari 10 nauplii hidup. Konsentrasi  ekstrak : 250 ppm, 500 ppm, 750 ppm, dan 1000 ppm. Sepuluh nauplii hidup ditambahkan ke setiap konsentrasi, dan volume akhir disesuaikan menjadi 1 ml menggunakan air laut buatan (35 ppt). Botol kontrol negatif berisi 1 ml air laut buatan, sedangkan botol kontrol positif berisi 50% etanol dalam air laut. Setelah 24 jam, semua botol diperiksa dengan senter/kaca pembesar, dan jumlah nauplii yang bertahan hidup dihitung. Percobaan diulang tiga kali, dan data direpresentasikan sebagai Mean±SD
Hasil: Ekstrak etanol buah Stelechocarpus burahol (EESB) yang diuji toksisitasnya terhadap udang air asin memiliki nilai konsentrasi mematikan 50% (LC50) lebih dari 1000 ppm (2787,225 ppm).
Kesimpulan: Ekstrak etanol buah kepel tidak menimbulkan toksisitas terhadap udang air asin. Oleh karena itu, ekstrak etanol buah kepel dapat dipertimbangkan untuk penelitian lebih lanjut dengan uji akut, subakut, dan antifertilitas.
Discriminación y revitalización lingüistica en la escuela
Authors: Santiago Martínez Silvia
Published: October 2024

México tiene múltiples rostros y sonidos diversos que hacen una nación pluricultural. El reconocimiento de la pluriculturalidad, como el caso del estado mexicano obedece en dos planos: nacional e internacional.
Margo Glantz y el permanente giro de las letras
Authors: Cavallin Calanche Claudia
Published: October 2024

Cuando una palabra que simbolizaba el ícono de un pájaro azul y móvil, creado por el artista Martin Grasser, es sustituida por una única letra brevemente delineada como un nuevo cruce carcelario, el tiempo se detiene, mientras las conversaciones sobre la Inteligencia Artificial se multiplican en el antiguo Twitter.
Evaluación de la educación superior en México: Desafíos y propuestas frente al paradigma intercultural
Authors: Martínez Buenabad Elizabeth , Fagetti Antonella
Published: October 2024

El propósito del presente artículo busca reflexionar a la luz de las recientes modificaciones hechas a la Ley General de Educación Superior (LGES, 2021) y su vínculo con el paradigma de la interculturalidad, cuáles son las expectativas y compromisos que plantea la actual política del gobierno federal en el marco de la Propuesta de Política Nacional de Evaluación y Acreditación de la Educación Superior (PNEAES).
Movilidad humana, cultura digital y comunicación intercultural en la frontera México-EUA
Authors: Méndez-Fierros Hugo , Fernández Huerta Christian Alonso
Published: October 2024

Aquí reportamos algunas reflexiones a la luz de la primera mirada diagnóstica en torno a una de las escuelas elegidas para tal efecto, con el fin de pensar en voz alta la forma en que la cultura digital es condición importante, aunque no única, para la construcción de procesos de comunicación y aprendizaje intercultural. Destacamos la necesidad de recursos digitales para el encuentro y la comunicación en un espacio que presenta fronteras simbólicas a partir de las barreras idiomáticas.
Territorio y memoria biocultural, referentes de la educación intercultural y la NEM
Authors: García Saúl Alejandro , Mendieta Ramírez Araceli
Published: October 2024

Este trabajo es resultado de experiencias académicas e investigativas que se recuperan del estudio de la interculturalidad y el territorio, con docentes frente a grupo en educación básica, y se propone como referente de pr.cticas pedagígicas para el modelo educativo de la Nueva Escuela Mexicana (NEM).
The Analysis of the Implementation of the Dealer Management System (DMS) at PT X
Authors: Kudu Diza Izallia Ananda Putri , Puji Wahono  , Rizki Firdausi Rachmadania
Published: October 2024

Dealer Management System (DMS) is a management information system that is very useful for increasing the efficiency and productivity of automotive company administration. In current technological developments in the automotive industry, efforts to implement digitalization systems in a business industry continue to be carried out and developed. The implementation of the Dealer Management System (DMS) illustrates changes to modern work processes by utilizing technological developments. This research was conducted to determine the implementation of the Dealer Management System (DMS) at PT X. This research is qualitative research with descriptive methods. The data collection techniques used were observation, interviews, documentation and literature study. During its use, the Dealer Management System (DMS) at PT X has been quite effective in supporting planning, decision making and control functions. The implementation of the Dealer Management System (DMS) at PT X has provided benefits from various operational aspects, thereby increasing efficiency and productivity.
Review The Application of Factors that Influence Customers in Increasing Purchase Intention for Local Brand Sneaker Footwear Products in Indonesia
Authors: Ani Solihat  , Arief Helmi  , Yudi Azis  , Rita Komaladewi
Published: October 2024

The competition in the footwear product business in the world is very competitive. Asia is the highest footwear producer at 88.2% as well as the highest consumer at 56%, followed by the Americas which produces footwear at 6.1% while the consumption rate reaches 20.8%. This proves that countries in Asia export a lot to other countries including Indonesia as the third highest exporter of footwear after China and Vietnam. The total footwear produced by the State of Indonesia reaches 1083 million pairs of footwear. Indonesia not only meets domestic needs, but Indonesia exports footwear up to 427 million pairs, but many imported products also enter Indonesia up to 150 million pairs. This is certainly a competition between imported/global brand footwear products and local brands. However, the results of the distribution of a questionnaire conducted by an online survey named Kurious in 2023 with https://www.kurious.id website address, with a total of 399 respondents conducted from February 14 – February 22, 2023. The purpose of this study is to find out what factors can affect customers in increasing the purchase intention of local brand sneaker footwear products in Indonesia. The method used in this study is a qualitative method using a descriptive approach of analysis and analysis through literature review from various Scopus publications on existing problems. The results of the study show that the factors that can influence customers in increasing the purchase intention of local brand sneaker footwear products in Indonesia are divided into 3 perspectives, namely consumers consisting of ethnocentrism or nationalism, emotional attitudes of liking local brands, then from the perspective of producers consisting of increasing creativity, innovation, durable product quality and conducting intensive promotions with the support of celebrities to influencing consumer behavior and then the third from a cultural perspective / cultural environment, including creating a taste for local products
Time and Metrology
Authors: Fanton Jean-Pierre
Published: September 2024

The recourse to Quantum Mechanics for the definition of the International System of Units has been the trigger of significant progress. In the first part of the paper, we briefly recall the definitions of units now in use for the basic quantities. We summarize the levels of precision available today within the framework of these definitions.
Time, whether we are aware of it or not, is a very special physical quantity. We therefore expose the extended use that could be made of the expression of physical quantities by means of time, like what is already practiced for the masses, expressed by means of energies. We detail a little more the case of the electrical quantities voltage and resistance which, without being basic quantities, benefit from new approaches thanks to two quantum phenomena: the Josephson effect, and the Quantum Hall Effect.
But time is not an absolute. The next part of the paper exposes the corresponding teachings brought by Special Relativity on the one hand, and General Relativity on the other hand.
Finally, the perspectives of the field are approached under the aspect of the metrological repercussions. Indeed, the technologies applicable to the measurement of time lead to performances that can be considered extraordinary in absolute terms, and in any case superior in relative to anything that can be achieved for other physical quantities.
In conclusion, we examine the challenge that may represent the achievement of ever-increasing metrological performance for all physical quantities, and for time in particular, and the perspectives opened up for research in the domain by fields of knowledge not yet covered.
Bearing fault detection using second-order moment spectrum and adaptive time-varying morphological filtering
Authors: Bouaouiche Karim , Menasria Yamina , Khalfa Dalila , Soumia Teyar , Hassina Gheribi
Published: September 2024

The second-order moment spectrum is a method designed to simplify the complex shape of the spectrum, thus facilitating its interpretation for the identification and localization of defects based on peak frequency. Generally used as a final step in defect detection methods, this method offers the advantage of a more easily interpretable spectral shape. Compared to the shape of the spectrum of the vibration signal defined by the Fourier transform, which includes sidebands composed of peaks of large amplitude at different frequencies, the spectrum generated by the second-order moment spectrum method stands out for its simplicity. Starting from the mean and standard deviation of the vibration signal, the second-order moment can be defined as the power of the ratio between the standard deviation and the difference between the signal and the mean. Next, the Fourier transform is applied to express the second-order moment spectrum. The performance of the second-order moment spectrum is evaluated using the principle of comparison with the envelope spectrum obtained by the Hilbert transform. Vibration signals are analyzed using two methods: adaptive time-varying morphological filtering and second-order moment spectrum. After applying these methods to the signals from the database, we observe high-amplitude peaks at the frequencies corresponding to inner ring and ball defects. The second-order moment spectrum gives similar results to those obtained with the Hilbert transform envelope.
Calibration methods for high frequencies: Development and validation
Authors: Cundeva-Blajer Marija , Dimitrovski Gjorgji , Demerdziev Kiril , Kafedziski Venceslav , Josifovski Goran
Published: September 2024

The paper presents an introduction of an advanced method for calibration of high-frequency instruments, such as oscilloscopes, frequency counters and function generators that operate at the frequencies between 1 MHz and GHz range. Based on conducted thorough survey of the needs for calibration of high-frequency measurement devices in the region of Southeast Europe, and the identified calibration and measurement capability gap in comparison to the international metrology offer, the Laboratory for Electrical Measurements at Ss. Cyril and Methodius University in Skopje developed new methods, following the general recommendations of the EURAMET cg-7 Calibration Guide. An original approach in the design of the experimental procedure, and a novel data fusion concept for the evaluation of the measurement uncertainty is deployed. The paper also investigates and resolves some challenges of setting up an unbroken measurement traceability chain, and uncertainty estimation for calibration in the domain of high frequencies. The established and accredited calibration capabilities are essential for the region of Southeast Europe, where the metrology facilities for the calibration/testing of high frequency electronic devices are inadequate to meet the conformity assessment needs of the quickly growing automotive supply chain sector, and the needs of other electrical and electronic industries.
Spatial evaluation of the museum experience in converted heritage: the case of the National Bardo Museum in Tunisia
Authors: Bouhamed Rym
Published: September 2024

This paper addresses the evaluation of the conversion of the Bardo museum in Tunisia. Indeed, buildings converted into exhibition spaces rarely adapt perfectly to their new functions. Following this perspective, we propose to answer two major questions: How can we objectively evaluate the conversion of the Bardo museum, which was originally built as a seat of power and residence purposes and converted into an exhibition space? What criteria can be used to evaluate it while respecting international charters?
Through the spatial analysis carried out on the subject, our approach allowed us to highlight the spatial properties of the museum using the Depthmap simulation based on Spatial Syntax, a questionnaire, and the observation technique of Wayfinding. We have developed an objective analysis tool to evaluate the reliability of the conversion and the challenge of transforming a traditional and historical space through its architecture into a space that will fulfil a new 'function'. Hence, we deduced through this method that this conversion is a partial success.
Geodatabase, metric reconstruction and a GIS platform of historical-archaeological sites in Aquino
Authors: D'Urso Maria Grazia , Aldrighettoni Joel
Published: September 2024

This paper presents the contents of a geodatabase developed from the outcomes of survey operations carried out, in several stages since 2015, within the archaeological context of the Roman city of Aquinum, in southern Lazio. The proposed geodatabase integrates traditional topographic surveying techniques with total station, GPS and GNSS geodetic receivers with photogrammetric surveys and terrestrial laser-scanner (TLS) measurements, including the realization of HBIM (Historical Building Information Modeling) models, to investigate some specific historical-archaeological evidence useful to understand the Roman and medieval urban structure of the city. The processing and management of the metric and information datasets were entrusted to a GIS platform, implemented in the opensource Quantum-GIS software, to optimize the flowchart of the acquisition/processing process and to realize an intra-site Web-GIS useful for the visualization and dissemination of the results. The methodological-operational approach applied in the research activities highlights the fundamental contribution that the technological innovations of geomatics can provide for the construction of elaborate knowledge concerning cultural heritage, also becoming the base for the elaboration of more complex and detailed analyses. In this case, for example, the HBIM digital model of the Church of Santa Maria of Libera was also used for an in-depth study in the field of structural engineering, as input to model the masonry vaults of the aisles of the church and assess their structural safety through the analysis methodology denominated "Thrust Network Analysis (TNA)." In addition, the high-precision 3D models developed from detailed photogrammetric measurements of the archaeological fragments and human remains found in the excavation areas made it possible to create interesting "visual digital products" that are immediately understandable even for non-experts, and thus particularly useful for wide-ranging knowledge dissemination.
Smart tools for archaeological survey in different frameworks and contexts: approaches, analysis, results
Authors: Brienza Emanuele
Published: September 2024

The world of geomatics today provides new tools, smart and low cost, for archaeological survey, from geographical positioning to detailed drawing and graphic documentation of past evidence. These instruments, light and not bulky, interface directly with tablets, iPads or smartphones via intuitive applications and speed up the data collection in the field: archaeological data collection seems not to be a big issue today and 3D survey appears to be accessible even to less experienced archaeologists. We have tested the Trimble Catalyst DA2 smart system for centimetric georeferencing at the Curiae Veteres in Rome (Italy), at the Sun Temple of Niuserra, in Abu Ghurab (Egypt) and inside the ancient site of Eridu in Iraq: it was a good opportunity to check the accuracy of this tool, especially when associated to detailed and close-range survey activities, related to landscape archaeology and stratigraphic excavations. As we will see, if the instrument cannot replace more precise measurement tools still today (such as total station or laser scanner), in the field of georeferencing can be alternative to more expensive and complex GNSS systems, and it proved to be quite effective in systematic archaeological survey of large areas, especially in association with digital aerial photogrammetry made by UAV-UAS.
A multidisciplinary approach for the evaluation of the archaeological heritage of Borbona (Rieti, Italy)
Authors: Cozzolino Marilena , Gentile Vincenzo , Giorgi Cecilia , Mauriello Paolo
Published: September 2024

The area of Borbona (Rieti, Italy) has been sparsely researched from a historical and archaeological perspective. In order to obtain new data on unexplored areas, a systematic study was carried out combining archaeological explorations, photogrammetric surveys and geophysical prospections. All data was stored in a Geographic Information System, which enabled spatial analysis and the creation of thematic maps. The aim of the research was to discover the unknown territory and trace its origins. The project identified ancient habitats and significant Roman architectural fragments. The research aims to pass on the history and culture of Borbona to future generations and promote a sense of belonging. The protection of historical heritage and archaeologically endangered areas as well as the enhancement and promotion of existing cultural assets are fundamental measures to increase the attractiveness of the land in the present and preserve its identity in the future.
Towards the definition of Transformation Stratigraphic Unit (TSU) as new section of the extended matrix methodology
Authors: Scopinaro Eleonora , Demetrescu Emanuel , Berto Simone
Published: September 2024

This study explores the interpretation of degradation and alteration phenomena as stratigraphic units, showing the preliminary results of ongoing research concerning new investigative methods and tools useful to formalize transformative processes on built heritage, in a chronological perspective. Merging conservation sciences with archaeology, the study introduces a new section of the Extended Matrix (EM) method: the Transformation Stratigraphic Unit (TSU). The aim of this work is to assess a new method for documenting and investigating cultural heritage, by generating scientifically reliable reconstructive hypotheses, and by analysing and comparing the mutual interaction of different degenerative phenomena and their relationship. The current workflow, still tentative, utilizes open-source tools and is designed to be replicable and it has been applied to the case study of the architectural complex of S. Pietro in Segni (RM).
The current workflow, still tentative, utilizes open-source tools and is designed to be replicable and it has been applied to the case study of the architectural complex of S. Pietro in Segni (RM).
Two early cinquecento Renaissance polyptychs by Antonio de Saliba on Sicily and Malta: an art-historical and scientific investigationtion
Authors: Bartolo Andrea Luca , Vella Charlene
Published: September 2024

This study focuses on two Renaissance polyptychs that were produced by Antonio (1466/7–c. 1535) and Giovanni de Saliba (doc. 1461–1517?), referred to in this study as the Taormina Polyptych (1503–04) and the Rabat Polyptych (1510–15). Through art-historical research and scientific analyses, this study sheds light on their original visual completion and manufacturing techniques. The Taormina Polyptych, located at the Cathedral of St Nicholas of Bari in Taormina, Sicily, underwent thorough on-site examination, revealing details overlooked in prior studies. A two-dimensional digital reconstruction, the creation of which was aided by early 20th century photographs, provided insights into its original appearance. The Rabat Polyptych, once situated in the Franciscan Observant Church in Rabat, Malta, faced dismemberment in 1785, leading to challenges in reconstruction. By analysing historical documents and employing digital reconstruction techniques, the original framework was hypothesised. Scientific studies, including histological and stratigraphic analyses of wood and pigment samples respectively, carried out on two newly discovered predella panels from the Rabat Polyptych, provided insight on Antonio de Saliba's techniques. The digital reconstructions and insights into manufacturing techniques contribute to scholarship on Antonio’s works in the context of Sicilian Renaissance art.
Overcoming traceability challenge in air quality measurements by developing reference gas mixtures of CO2 in a typical indoor/outdoor range for future relevant IoT technology applications
Authors: AlYami Najji H. , AlOwysi Abdullah S. , M. Ahmed Khaled
Published: September 2024

High-resolution air quality monitoring using inexpensive sensor systems has attracted a lot of attention in the context of smart cities. However, in order to preserve metrological traceability, these systems must be regularly recalibrated.  The necessity of quality control, dependability, and traceability of analytical data has received a lot of attention lately. IoT sensors can also be used to monitor the condition of equipment and ensure that it conforms with safety rules, given the rapid advancement of new technologies and their numerous everyday uses. Therefore, the primary motivation for our study endeavour was to provide reference gas mixtures to calibrate those sensors optimally in the future while keeping traceability to SI units, which is an important and demanding duty of gas standard laboratories at NMIs. Given the significance of metrological issues in the current context, the national measurement and calibration centre (SASO-NMCC) developed the methodology for preparing such primary standard gas mixtures (PSMs) through standardized gravimetric method in order to improve measurement capabilities and provide a level of confidence regarding greenhouse gas standards. Compatibility check, as per ISO 6143:2001, for the gas chromatography thermal conductivity detector (GC-TCD) with respect to the gravimetric assigned values with its associated combined uncertainty is also presented for each produced PSM. The relative expanded uncertainty of the carbon dioxide standard mixture, taking into account the contributions from verification analysis by GC-TCD, was less than 0.7 % for the prepared range of (0.00499 ± 0.00006) to (0.1996 ± 0.000424) mol/mol. This is comparable to the average of 0.25 % relative uncertainties presented on international standards mixtures.
The Effect of Corporate Governance Capacity on Herd Behavior
Authors: Özkahveci Esra , Konak Fatih , Kılıç Sabiha
Published: September 2024

Behavioral finance, which rejects the basic assumption of traditional finance and argues that individuals do not always act rationally and that psychological factors have an effect on investor behavior, reveals the effect of cognitive biases and emotional factors on the investor. Herd behavior, which is one of these emotional factors, is to imitate the behavior of others in its most general definition. In addition, herd behavior, which affects investor behavior and therefore financial markets, is a behavioral attitude that shows that investors act together. On the other hand, corporate governance, which is becoming increasingly important by businesses, is a system in which company activities are managed and controlled. Enterprises with the highest corporate governance rating score can be included in the Borsa Istanbul Corporate Governance Index. The main purpose of working within the framework of herd behavior and corporate governance is to reveal the possible effect of corporate governance rating on herd behavior from a different perspective. In this context, the Christie and Huang (1995) Model and the Chang, Cheng and Khorana (2000) Model are used in the research. In terms of herd behavior, no herding behavior was found in 16 other prominent indices in Borsa Istanbul according to the results of Christie and Huang (CH) Model, while herd behavior was detected in some indices according to the results of Chang, Cheng and Khorana (CCK) Model. In addition, no evidence was found in favor of herd formation according to both the CH Model and the CCK Model in companies included in the Corporate Governance Index within the scope of herd behavior and grouped as high/low corporate governance score within the framework of the determined criteria.
Tumor immune evasion abrogated by COUP-TFII reprogramming of the vasculature
Authors: Zhu Yu , Brulois Kevin , Dinh Thanh , Pan Junliang , Butcher Eugene
Published: October 2024

T cell scarcity in tumor tissues poses a critical challenge to cancer immunotherapy. Here we manipulate the tumor vasculature, an essential regulator of immune cell trafficking, to reinvigorate anti-tumor T cell responses in “cold” tumors. We show that ectopic pan-endothelial expression of COUP-TFII, a master transcription factor for venous development, induces molecular programs of post-capillary venules in tumor endothelium. Venular reprogramming selectively promoted T cell recruitment into tumors, inhibited tumor growth in mouse models of breast and pancreatic cancers, and sensitized tumors to immune checkpoint blockade and adoptive T cell transfer therapies. Mechanistic studies show that enhanced recruitment of anti-tumor T cells and tumor inhibition are mediated by COUP-TFII-induced vascular adhesion receptors. Our study supports a pivotal role of vascular endothelial cells in governing tumor immune evasion, and proposes venular reprogramming as a novel therapeutic strategy to bolster anti-tumor immunity and immunotherapy.
Common genetic variants associated with risk of Parkinson's disease in non-European populations: a PROSPERO registered systematic review based on genome-wide association studies
Authors: Santos Júlio César Claudino dos , Pires Jackson Frederico , Mano Gabriela Braga Cabrera , Goes João Vitor Caetano , Gusmão Camilla Teixeira Pinheiro , Barreto-Vianna André Rodrigues da Cunha , Carlo Ettore José Filippi , Viana Tayenne Nélly de Lucena , Lins Camila de Almeida , Stangherlin Luana , Leitão Renata Ferreira de Carvalho , Junior Howard Lopes Ribeiro , Dias Fabricyo de Faria Esposito
Published: October 2024

Parkinson's disease (PD) is a complex genetic neurodegenerative disorder. Epidemiology genetic discoveries have increased our understanding of the molecular contributors to Parkinson's pathophysiology, especially when associated with the advent of genome-wide association studies (GWAS) technologies in the discovery of the risk linked to common germline genetic variants. A biggest limitation of studies on genetic susceptibility to PD is the lack of information describing the impact of individuals’ ancestry on risk associations, especially in non-European populations. Current genetic data are mainly based on individuals of European origin, particularly those included in the UK biobank project. The effects of these ethical discrepancies can directly impact the discovery of risk variants associated with PD susceptibility and clinical management of PD patients in admixture populations, for example. Thus, we performed a PROSPERO-registered systematic review (#CRD42022368534 and PRISMA checklist) to elucidate the current state of the art about the role of common genetic variants based on GWAS studies in advancing precision medicine for PD susceptibility and pathobiology in multiethnic and non-European populations. Also, we talk about whether there are similarities or discrepancies of these data in relation to genomic data obtained in studies with PD patients of European origin.
Timing of rehabilitation and occurrence of pressure ulcers in patients with cervical spinal cord injuries
Authors: Yamauchi Risa , Sasabuchi Yusuke , Yasunaga Hideo , Aso Shotaro
Published: October 2024

Study design: A retrospective cohort study using a nationwide Japanese inpatient database.
Objectives: To investigate the association between the timing of rehabilitation interventions and the occurrence of pressure ulcers in hospitalized patients with cervical spinal cord injuries between 2010 and 2022 in a real-world clinical setting.
Setting: We used the Diagnosis Procedure Combination database, a nationwide Japanese inpatient database.
Methods: We included patients with cervical spinal cord injury who underwent spinal surgery within 3 days of admission between July 2010 and March 2022. We defined rehabilitation within 2 days of surgery as early rehabilitation and ≥3 days of surgery as non-early rehabilitation. The primary outcome was treating severe pressure ulcers ≥4 days after admission, and the secondary outcomes were length of hospital stay, hospitalization costs, and in-hospital mortality. Propensity score inverse probability of treatment weighting was conducted to compare the outcomes between the early and non-early rehabilitation groups.
Results: We identified 5,162 eligible patients, 3,434 (66.1%) of whom underwent early rehabilitation. After weighting, the occurrence of treating severe pressure ulcers showed no significant difference between the early and non-early rehabilitation groups (odds ratio [OR], 1.30; 95% confidence interval [CI], 0.79–2.12; P=0.297). The early rehabilitation group had lower total hospitalization costs (difference, –3.2%; 95% CI, –6.1% to 0.0%; P=0.043) and shorter length of hospital stay (difference, –4.5%; 95% CI, –8.4% to 0.0%; P=0.034) than the non-early rehabilitation group.
Conclusion: This study found no significant difference in the development of severe pressure ulcers between the early and non-early rehabilitation groups.
Successful difelikefalin use in severe chronic kidney disease-associated pruritus in a patient with tertiary hyperparathyroidism: a case report
Authors: Werzowa Johannes M. , Hemetsberger Margit
Published: October 2024

Background
Chronic kidney disease-associated pruritus (CKD-aP) is a frequently experienced, unpleasant skin condition. Difelikefalin is indicated for the treatment of moderate-to-severe CKD-aP in adult patients on hemodialysis. Reports of difelikefalin effectiveness in complex patient cases encountered in routine clinical practice are rare.
Case presentation
The presented patient had a complex interplay of morbidities, most notably diabetes mellitus type 2, tertiary hyperparathyroidism, end-stage renal disease (ESRD), and CKD-associated mineral bone disease (CKD-MBD), all of which are associated with the development and severity of CKD-aP. The patient’s CKD-aP proved resistant to H1-receptor antagonists and gabapentin and showed no improvement after parathyroidectomy. Treatment with difelikefalin rapidly and sustainedly improved symptoms, with a brief recurrence of itch towards the end of each long interdialytic interval. Apart from a short episode of vertigo at initiation of treatment, no adverse events were observed over the long duration of treatment (more than two years).
Conclusions
Difelikefalin, an agonist of the kappa opioid receptor, acts independently of the itch-causing mechanisms associated with the comorbidities present in the patient, notably diabetes mellitus type 2, tertiary hyperparathyroidism, ESRD, and CKD-MBD. This may explain the sustained effectiveness of difelikefalin throughout the patient’s complex clinical history.
Untersuchungen zur muskarinischen Modulation der GABAergen Übertragung im Colliculus inferior der juvenilen Ratte
Authors:   , Yigit Mehmet
Published: October 2024

Um die muskarinische Modulation der GABAergen Übertragung zu untersuchen, wurden mit Hilfe der Patch- Clamp- Technik an akut isolierten IC Schnitten der Ratte (P4-P14) inhibitorische postsynaptische Ströme aufgezeichnet (IPSCs). Die Aufnahmen erfolgten bei einem Haltepotential von -60mV. In allen Experimenten konnte unter der Anwesenheit von Strychnin (0,5μM, Glycinrezeptor- Antagonist) und Kynurensäure (1mM; Glutamatrezeptoren- Antagonist) spontane GABAerge IPSCs in allen untersuchten IC-Neuronen aufgezeichnet werden. Die Anwesenheit von Kynurenat blockierte auch Ströme, die möglicherweise durch nAChRen mit der Untereinheit α7 vermittelt wurden. Die Muskarin (1μM) Applikation zeigte, eine deutliche Erhöhung der IPSCs- Frequenz (618% der Kontrolle), was uns beweist, dass die Aktivierung von mAChRen im IC zu einer Steigerung der GABAergen Übertragung führt. Die durch Muskarin induzierten IPSCs konnten komplett durch den GABAA- Rezeptor- Antagonisten Bicucullin (10μM und 50μM) blockiert werden. Dies zeigte, dass die IPSCS durch GABAA- Rezeptoren vermittelt wurden. 4-DAMP (50nM; M3-Rezeptor Antagonist) blockierte den durch Muskarin ausgelösten Anstieg der IPSC-Frequenz. Die Muscarin-Antagonisten Telenzepin (50nM; M1-präferierend), Methoctramin (10μM; bevorzugt M2) und Himbazin (10μM; bevorzugt M4) sowie der Nikotinrezeptor-Antagonist Mecamylamin (10μM) beeinflussten die Muskarinwirkung nicht signifikant. Diese Ergebnisse deuten darauf hin, dass die muskarinische Modulation der GABAergen Übertragung hauptsächlich durch den M3-Rezeptor vermittelt wird, während M1-, M2- und M4- sowie Nikotinrezeptoren nicht wesentlich beteiligt sind. In Gegenwart von Tetrodotoxin (0,5μM) konnte Muscarin die IPSC-Frequenz nicht erhöhen. Dies lässt auf eine über spannungsabhängige Natriumkanäle vermittelte erhöhte Transmitterausschüttung schließen. Zudem spricht dies für eine präterminale Modulation der GABAergen Transmission durch mAChRen. Muskarin erhöhte die Häufigkeit der GABAergen IPSCs, ohne ihre Amplituden und Zerfallskinetik zu beeinflussen, was auf einen präsynaptischen Mechanismus hindeutet. Muskarin veränderte den Membranruhestrom und die Leitfähigkeit in den untersuchten IC-Neuronen nicht. Der Mechanismus der durch Muscarin induzierten Verstärkung der GABAergen Übertragung im IC muss noch abgeklärt werden.
PREVALÊNCIA DE PEDICULOSE EM ESTUDANTES DO MUNICÍPIO DE NOVA IGUAÇU, ESTADO DO RIO DE JANEIRO, BRASIL
Authors: De Oliveira André Fernandez , Norberg Antonio Neres , De Oliveira José Tadeu Madeira , Ribeiro Paulo César , Norberg Paulo Roberto Blanco Moreira , Freire Nicolau Maués Serra
Published: October 2024

A pediculose por Pediculus humanus capitis é uma infestação de distribuição cosmopolita, em qualquer idade, mas prevalente em crianças, e se constitui um dos sérios problemas de saúde pública na atualidade. Objetivo: Avaliar a prevalência de pediculose em escolares da rede pública de ensino da cidade de Nova Iguaçu, estado do Rio de Janeiro. Pacientes e métodos: Estudo descritivo, transversal, realizado com 10.851 crianças com idades entre 4 e 12 anos, matriculadas em 72 escolas do município de Nova Iguaçu. A avaliação consistiu na inspeção visual e palpação das cabeças por dois minutos, com atenção à nuca, pescoço e região retroauricular, com a manipulação do cabelo. O material encontrado foi identificado no Laboratório de Parasitologia da Universidade Iguaçu. Resultados: Dos 10.851 estudantes examinados, 4.765 eram meninos e 6.086 eram meninas; do total, 4.023 estavam positivos para pediculose, correspondendo ao coeficiente de prevalência de 37,07%. A cor do cabelo influencia o parasitismo, mas o tipo de cabelo não. O comprimento do cabelo só influenciou no parasitismo dos meninos. Conclusões: A pediculose capitis constitui um importante problema de saúde pública entre estudantes do ensino fundamental, e deve ser integrada em programas de prevenção e controle de doenças infecto-parasitárias.
DA OCUPAÇÃO DOS LUGARES SINTÁTICOS DE SUJEITO E OBJETO - RETROSPECTIVAS
Authors: Buthers Christiane Miranda
Published: October 2024

Este artigo objetiva realizar uma retrospectiva dos aspectos semântico-sintáticos relacionados à ocupação dos lugares sintáticos de sujeito e objeto. Através da análise de textos de vários autores, objetiva-se chegar a uma constatação de que não apenas aspectos relacionados à sintaxe influenciam na localização e identificação do sujeito, como também fatores relacionados aos modos de enunciação desempenham um papel considerado fundamental. Conclui-se que é de extrema importância o poder da enunciação no trabalho de investigação linguística, tendo em vista que ela amplia as possibilidades do estabelecimento de uma gramática realmente diferenciada – que considere aspectos exteriores como constitutivos dos fatos gramaticais, pois a grande questão para a Linguística é onde colocar a exterioridade.
AVALIAÇÃO ANTOPOMETRICA DE CRIANÇAS COM IDADE ENTRE 4 E 5 ANO PARA ESCOLHA DE MOBILIARIO PARA SALA DE AULA.
Authors: Franca Silva Gustavo Thayllon , Luz Flavia Aparecida
Published: October 2024

Este estudo de caso faz parte de uma pesquisa que investiga o ambiente escolar e e as adaptação dos alunos ao mobiliário já existente. Vamos apresentar a importância que o uso do mobiliário adequado pode influenciar no rendimento escolar. Pois tem-se observado uma grande lacuna de aplicações e adequações ergonômicas. O estudo foi realizado com 42 crianças com idade entre 4 e 5 anos na população presente em uma escola da rede particular na cidade de Ipatinga –MG. Realizaremos estudos das medidas antropométricas necessárias para a escolha do mobiliário (mesas e cadeiras) Os resultados nos permitiram concluir que  nesse ambiente que os alunos passam maior parte do tempo e que seja maior a influência dele na postura esses desconfortos serem a causa de distração e inquietação
UMA ANÁLISE DA PARTICIPAÇÃO DA CONTABILIDADE NO SUCESSO DE UMA FIRMA DO RAMO DE FERTILIZANTES DE IBATIBA-ES
Authors: Guerra Cícero José Oliveira , Santos Adenis Campos dos , De Souza Fabrício Afonso
Published: October 2024

Na era da inovação faz se necessário que as empresas estejam sempre questionando seus padrões para manter-se neste mercado amplamente competitivo, desenhando novas estratégias de negócios para alcançarem sucesso nas suas táticas de gestão. Esse ambiente competitivo pode ser explicado pelas novas tecnologias e a informatização que altera o ambiente interno e externo das empresas. Neste contexto, o objetivo desta pesquisa é verificar a participação da contabilidade no sucesso de uma firma situada na cidade de Ibatiba-ES que atua no ramo de fertilizantes. Para encontrar os resultados propostos nesta pesquisa foi construída metodologicamente, uma entrevista com o gestor da firma de fertilizantes e questionário fechado, posteriormente analisado pela escala likert. Os achados mostrar que a empresa não utilizam totalmente as informações contábeis para tomar decisões, mas não foi desconsiderada a relevância das ferramentas contábeis para diminuição do ônus tributário de forma legal e outros aspectos de gestão.
Pectin Changes during Freezing and Storage of Plant Products
Authors: Rumyanceva Olga
Published: October 2024

To keep up with the growing demand, producers of frozen plant products have to develop new freezing technologies that would preserve the sensory and biological properties of fruits and vegetables. Pectins are important structural and moisturebinding components of plant cells that improve their stability at high and low temperatures. The research objective was to study the effect of blanching and various freezing methods on the composition of pectin substances during long-term storage of fruits and vegetables.
The research featured scorzonera, salsify, kohlrabi, apples, and plums. The freezing modes included two temperature modes (–24 and –35°C) and three freezing methods, i.e., blanching, air-freezing represented by natural air-freezing, artificial convection, and fluidization, and immersion in a mix of water, ethyl alcohol, sucrose, and sodium chloride. The frozen samples were stored in sealed bags at –18°C for 7–12 months. The water-soluble pectin, intermediate fraction, and protopectin obtained by extraction were determined using the colorimetric carbazole method. The qu alitative analysis relied on infrared spectroscopy.
Blanching reduced the pectin content by 2–10% in vegetables and by 18–21% in apples. Fluidization and immersion freezing had the least damaging effect on pectins. Air-freezing with natural convection caused the greatest damage to protopectin. During storage, the maximal loss of pectins (66%) occurred in the salsify sample subjected to natural air convection at –24°C. The least damage (9%) was detected in the kohlrabi sample frozen at –24°C in ice environment. A higher moisture content in the native state correlated with minimal losses of pectins by the end of refrigerated storage. The research also included identification of absorption bands for pectic substances in fro zen scorzonera and salsify.
In this study, pectin content depended on moisture content in tissues, blanching process, and freezing method. All frozen samples demonstrated losses of protopectin and an increase in the intermediate fraction. An intense freezing process had a positive effect on the pectin content during long-term storage. However, after six months of storage, the samples demonstrated significant fractional changes and pectin losses.