bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of self‐performance management video program on patients receiving hemodialysis
Authors: Cho Hyeyoung , Park Sunghee
Published: November 2019

Aim

This study attempted to investigate the effects of a self‐performance management video program using a tablet PC on self‐care knowledge, self‐care behavior, state anxiety and physiological index in patients receiving hemodialysis.

Methods

This study was an experimental research design. The participants of this study were 46 patients who were diagnosed with end‐stage renal failure and received hemodialysis on a regular basis in kidney centers (23: experimental group, 23: control group). The data collection period was from November 24, 2016 to January 3, 2017. The program was designed and organized by the researchers of this study according to previous studies consisting of six categories in a total 70‐min video program. The contents of the self‐performance management program were stored on the tablet PC, so that the patients were self‐led. All the patients who participated in the program were asked to complete three categories in a week. Therefore, it took 2 weeks to complete all contents of the six categories. After that, the patients were asked to repeat the 2‐week course twice. Therefore, the program was carried out for a total of 6 weeks. For the control group, a pamphlet was used.

Results

The anxiety of the experimental group was significantly decreased compared to the control group. Among the physiological index, potassium and albumin levels were statistically significant.

Conclusions

The self‐performance management video program using a tablet PC developed in this study seems to be applicable to patients receiving hemodialysis who need anxiety and physiological index management.
Dystopia, Utopia, Atopia
Authors: Hollywood Amy
Published: November 2019

In the face of contemporary critiques of dystopia as engendering political hopelessness and apathy, this article explores the instability of the category of itself. Bringing together work by the German jurist and political philosopher, Carl Schmitt, and the American ex‐patriot poet, H.D., I show that each engages in thought experiments that might be taken as dystopic, but just as easily as utopic – and hence, as refusing the sharp contrast on which these generic distinctions are made. Schmitt and H.D. also bring into play issues central to the work of the contemporary U.S. poet, Susan Howe, with which I close. Howe’s poetry and essays, particularly in The Nonconformist Memorial, lead me to posit the usefulness of the idea of atopia, a thinking of the past, present, and future in which the alpha privative points to a more radical kind of “no place” than that first posited by Thomas More’s utopia. At the center of my argument is the idea that literature – and other works of the imagination – may be the necessary non‐place, or place without the limitations of place, for thinking pasts and futures that are literally uninhabitable (as much as I may try, I can’t actually live in a book) – and yet whose psychic, imaginative, intellectual, and affective existence is vital for human life.
A YajQ‐LysR‐like, cyclic di‐GMP‐dependent system regulating biosynthesis of an antifungal antibiotic in a crop‐protecting bacterium, Lysobacter enzymogenes
Authors: Han Sen , Shen Danyu , Wang Yu‐Chuan , Chou Shan‐Ho , Gomelsky Mark , Gao Yong‐Gui , Qian Guoliang
Published: November 2019

YajQ, a binding protein of the universal bacterial second messenger cyclic di‐GMP (c‐di‐GMP), affects virulence in several bacterial pathogens, including Xanthomonas campestris. In this bacterium, YajQ interacts with the transcription factor LysR. Upon c‐di‐GMP binding, the whole c‐di‐GMP‐YajQ‐LysR complex is found to dissociate from DNA, resulting in virulence gene regulation. Here, we identify a YajQ‐LysR‐like system in the bacterial biocontrol agent Lysobacter enzymogenes OH11 that secretes an antifungal antibiotic, heat‐stable antifungal factor (HSAF) against crop fungal pathogens. We show that the YajQ homologue, CdgL (c‐di‐GMP receptor interacting with LysR) affects expression of the HSAF biosynthesis operon by interacting with the transcription activator LysR. The CdgL‐LysR interaction enhances the apparent affinity of LysR to the promoter region upstream of the HSAF biosynthesis operon, which increases operon expression. Unlike the homologues CdgL (YajQ)‐LysR system in X. campestris, we show that c‐di‐GMP binding to CdgL seems to weaken CdgL‐LysR interactions and promote the release of CdgL from the LysR‐DNA complex, which leads to decreased expression. Together, this study takes the YajQ‐LysR‐like system from bacterial pathogens to a crop‐protecting bacterium that is able to regulate antifungal HSAF biosynthesis via disassembly of the c‐di‐GMP receptor–transcription activator complex.
New Zealand's small town transition: The experience of demographic and economic change and place based responses
Authors: Nel Etienne , Connelly Sean , Stevenson Teresa
Published: November 2019

A significant percentage of the smaller urban centres around the world are losing people which raises questions regarding the appropriate responses to this challenge. Responses from the state have generally been muted, and as a result, concepts of new localism and new regionalism are useful for understanding the role played by place‐based leadership and partnerships between local businesses, community groups and individuals. Key within this space is the role of endogenous responses anchored on local social capital and resilience. This paper overviews key themes in the literature before examining statistical evidence of small town growth, stabilisation or decline in New Zealand. This leads into an examination of how three small towns in the country are responding to demographic and economic change. The cases illustrate the importance of local‐led responses to the debilitating effects of change and the degree to which place based development can be critical in the context of coping with change in small towns. The paper further argues that “right‐sizing” to a new economic and demographic reality may be the appropriate focus of local attention.
Anthropocene dwelling: Lessons from post‐disaster Christchurch
Authors: Westgate Justin
Published: November 2019

This article takes circumstances of post‐quake Christchurch as an analogue for Anthropocene emergency. I argue that Christchurch events are more than a reminder of the Earth's geologic volatility; for the Anthropocene‐as‐disaster, it is a prompt to contemplate what it is to dwell on unstable ground. Urban locations—towns, cities, mega‐cities—are all rendered vulnerable on the surface of an unruly planet, offering no absolute refuge from planetary fluctuations. Such unsettling is deeply felt, physically and psychologically, resulting in homelessness both literal and figurative. Ensuing analysis offers insight into potential strategies for unsettled planetary dwelling to come.
Identification of the complement 9‐binding protein in Setaria equina excretory‐secretory products
Authors: Abdel‐Latif Mahmoud
Published: November 2019

The current study aimed to detect the complement‐binding proteins in the excretory‐secretory (ES) products of adult filarial parasite Setaria equina (SeqES). Tests for complement activation pathways (CH50 and APH50) in normal human serum (NHS) after incubation with SeqES were performed. Quantitative detection of complement activation products like C3d and sC5b‐9 by ELISA in inulin‐activated NHS before and after addition of SeqES was estimated. Immunoblotting for 1D and 2D electrophoresed SeqES were performed for detection of C9‐binding protein. MALDI mass sequencing and multiple sequence alignment were performed for identification of the protein. The results showed an inhibitory effect of SeqES for complement activation pathways. This was confirmed by an obvious reduction in C3d and sC5b‐9 in inulin‐activated NHS. Immunoblotting showed the reaction of a protein at 21 kDa with human C9. The latter protein was identified as OV‐16 based on MALDI mass sequencing and multiple sequence alignment. In conclusion, S equina OV‐16 is the complement regulatory protein by its ability to bind C9 and inhibit the classical and alternative pathways of complement activation. This protein can be used as a target for therapeutic treatment or as an anti‐inflammatory agent in human diseases.
Treatment of prolapsed gland and cartilage deformity of the nictitating membrane with pocket technique and chondrectomy alone, or combined with a wedge conjunctivectomy: 132 dogs (1998‐2018)
Authors: Michel Julien , Lazard Patrick , Vigan Marie , Albaric Olivier
Published: November 2019

Objective

To evaluate the results obtained using Morgan pocket technique and chondrectomy (MPTC) alone, or combined with a wedge conjunctivectomy (MPTC + WC) for the treatment of prolapsed gland associated with cartilage deformity of the nictitating membrane (PGCD) in dogs.

Procedure

Medical records of dogs diagnosed with PGCD that received a MPTC or MPTC + WC were reviewed between 1998 and 2018. Success rate was defined by lack of recurrence of the prolapsed gland with a minimum of 6 months follow‐up. Histological examination of the excised cartilage was performed in 13 eyes.

Results

A total of 132 dogs (181 eyes) met the inclusion criteria. Median follow‐up time was 25 months (range, 6‐166 months). MPTC was used in 131 eyes with 91.6% success rate. MPTC + WC was used in 50 eyes with 100% success rate. Postoperative complications occurred in 6.9% and 4%, respectively, for MPTC and MPTC + WC, including lacrimal cysts (8 eyes) or corneal erosion (3 eyes). Recurrence and complications rates were significantly lower using MPTC + WC compared with MPTC in the giant breed dogs (P = .019 andP = .002, respectively), but not in the overall study population (P = .328 andP = .290, respectively). Histological cartilage anomalies were noted in 2/13 specimens from chronic PGCD.

Conclusions

MPTC + WC offers a good therapeutic option for giant breed dogs with PGCD. The combined technique provides a good apposition and mobility of the nictitating membrane onto the ocular surface and potentially reduces the risk of recurrence in these giant canine breeds.
Calculation of Gear Meshing Stiffness Considering Lubrication
Authors: Cheng Gong , Xiao Ke , Wang Jiaxu , Pu Wei , Han Yanfeng
Published: November 2019

Gear meshing stiffness is the key parameter to study the gear dynamic performance. However, the study on the calculation of gear meshing stiffness considering lubrication, especially mixed lubrication, is still insufficient. Based on the three-dimensional linear contact mixed elastohydrodynamic lubrication model and the contact stiffness calculation method of rough surface, a method for calculating the gear meshing stiffness under mixed lubrication is proposed in this paper. According to the proposed calculation method, the effects of speed, external load, and roughness amplitude on gear meshing stiffness are further explored. The method can take into account the real rough surface topography and lubrication in the meshing process, so it may be more advantageous than the conventional method to some extent.
Jet Impingement Heat Transfer Enhancement by U-Shaped Crossflow Diverters
Authors: Madhavan Srivatsan , Ramakrishnan Kishore Ranganath , Singh Prashant , Ekkad Srinath
Published: November 2019

Array-jet impingement is typically used in gas turbine blade near-wall cooling, where high rates of heat dissipation is required. The accumulated crossflow mass flux results in significant reduction in jet effectiveness in the downstream rows, leading to reduced cooling performance. In this paper, a jet impingement system equipped with U-shaped ribs (hereafter referred as “diverter”) was used for diverting the crossflow away from the jets emanating from the nozzle plate. To this end, a baseline configuration of array-jet impingement onto smooth target surface is considered, where the normalized jet-to-jet spacing (x/dj = y/dj) was 6 and the normalized jet-to-target spacing (z/dj) was 2. Crossflow diverters with thickness t of 1.5875 mm and height h of 2dj (= z) were installed at a distance of 2dj from the respective jet centers. Detailed heat transfer coefficients have been calculated through transient liquid crystal experiments carried out over Reynolds numbers ranging from 3500 to 12,000. It has been observed that crossflow diverters protect the downstream jets from upstream jet deflection, thereby maximizing their stagnation cooling potential. An average of 15–30% enhancement in Nusselt number is obtained over the flow range tested. This benefit in heat transfer came at a cost of increased pumping power to maintain similar flow rate in the system. At a given pumping power, crossflow diverters yielded an enhancement of 9–15% in heat transfer compared with the baseline case.
High Heterogeneity of Multidrug-Resistant
Enterobacteriaceae
Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams
Authors: Djukovic Ana , González-Barberá Eva M. , Sanz Jaime , Artacho Alejandro , Peñaranda Iván , Herrera Beatriz , Garzón María José , Salavert Miguel , López-Hontangas José Luis , Xavier Karina B. , Kuster Bernhard , Debrauwer Laurent , Rolain Jean-Marc , Sanz Miguel A. , Xavier Joao B. , Ubeda Carles
Published: November 2019

Multidrug-resistant
Enterobacteriaceae
(MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospitalized patients and the clinical factors that determine those levels.
Sugar-Phosphate Metabolism Regulates Stationary-Phase Entry and Stalk Elongation in Caulobacter crescentus
Authors: de Young Kevin D. , Stankeviciute Gabriele , Klein Eric A.
Published: November 2019

Metabolic control of bacterial cell shape is an important mechanism for adapting to environmental perturbations.
Caulobacter crescentus
dramatically elongates its polar stalk appendage in response to phosphate starvation. To investigate the mechanism of this morphological adaptation, we isolated stalk-deficient mutants, one of which had mutations in the phosphomannose isomerase gene (
manA
) that blocked stalk elongation, despite normal activation of the phosphate starvation response. The mutant ManA resulted in an imbalance in sugar-phosphate concentrations, which had effects on the synthesis of cellular envelope components and entry into stationary phase. Due to the interconnectivity of metabolic pathways, our findings may suggest more generally that the modulation of bacterial cell shape involves the regulation of growth phase and the synthesis of cellular building blocks.
Whole-Genome Sequencing of Corynebacterium diphtheriae Isolates Recovered from an Inner-City Population Demonstrates the Predominance of a Single Molecular Strain
Authors: Chorlton Samuel D. , Ritchie Gordon , Lawson Tanya , Romney Marc G. , Lowe Christopher F.
Published: November 2019

In some parts of the world,
Corynebacterium diphtheriae
has reemerged as a pathogen, especially as a cause of infections among impoverished and marginalized populations. We performed whole-genome sequencing (WGS) on all cutaneous
C. diphtheriae
isolates (
n
 = 56) from Vancouver’s inner-city population over a 3-year time period (2015 to 2018).
Differences in Antibody Responses against Chelonid Alphaherpesvirus 5 (ChHV5) Suggest Differences in Virus Biology in ChHV5-Seropositive Green Turtles from Hawaii and ChHV5-Seropositive Green Turtles from Florida
Authors: Work Thierry M. , Dagenais Julie , Willimann Anna , Balazs George , Mansfield Kate , Ackermann Mathias
Published: November 2019

Fibropapillomatosis (FP) is a tumor disease associated with chelonid herpesvirus 5 (ChHV5) that is an important cause of mortality in threatened green turtles globally. FP is expanding in Florida and the Caribbean but declining in Hawaii. We show that Hawaiian turtles mount antibodies to ChHV5 mainly in response to tumors, which are the only sites of viral replication, whereas tumored and nontumored Floridian turtles are uniformly seropositive. Tumor viruses that depend on tumors for replication and spread are rare, with the only example being the retrovirus causing walleye dermal sarcoma in fish. The Hawaiian strain of ChHV5 may be the first DNA virus with such an unusual life history. Our findings, along with the fundamental differences in the life histories between Floridian turtles and Hawaiian turtles, may partly explain the differential dynamics of FP between the two regions.
Bacterial Diversity of Water and Soil Samples from Dripping Springs in the Organ Mountains (New Mexico), Determined by Using 16S rRNA Gene Amplicon Sequencing
Authors: Kyndt John A.
Published: November 2019

Dripping Springs is located on the western side of New Mexico’s Organ Mountains. This is an initial microbial analysis of the spring water and surrounding microbial mat. Both soil-water and water samples showed a high level of microbial biodiversity consistent with the secluded and pristine nature of the area.
Parvimonas micraspondylodiscitis with psoas abscess
Authors: Yoo Li Jie Helena , Zulkifli Muhamad Danial , O'Connor Margaret , Waldron Ruth
Published: November 2019

Parvimonas micra(P. micra) is a Gram-positive anaerobic cocci, normally found in the oral cavity and rarely causes severe infections. We describe a rare clinical presentation ofP. micraas spondylodiscitis and psoas abscess with haematogenous spread in an adult patient. MRI lumbar spine detected L2 and L3 spondylodiscitis. Blood cultures were positive at 48 hours of incubation andP. micrawas identified on anaerobic culture after 72 hours. Isolates from bone biopsy confirmsP. micra. She was successfully treated with ceftriaxone, followed by oral metronidzole for a total of 8 weeks. The suspected origin of herP. micrawas a dental cavity. Anaerobic bacteria tend to be underestimated in spondylodiscitis. In cases of slow growing organisms, we emphasise the importance of performing accurate identification including anaerobic bacteria to guide management.P. micrashould be considered in patients with spondylodiscitis who had recent dental intervention or perioral infection.
The effect of human platelet lysate on corneal nerve regeneration
Authors: Huang Chin-Te , Chu Hsiao-Sang , Hung Kuo-Chi , Chen Lily Wei , Chen Mei-Yun , Hu Fung-Rong , Chen Wei-Li
Published: November 2019

Aim

This study aimed to test whether human platelet lysate (HPL) has neurotrophic ability for corneal nerve regeneration.

Methods

We measured the neurotrophic factors in human peripheral serum (HPS) and two commercially available HPLs, UltraGRO and PLTMax. In vitro, we compared the growth rates, neuronal differentiation and immunostaining of neuron markers in mouse neuroblastoma cell line (Neuro-2a) and primary culture of mouse trigeminal ganglion cells that were cultivated in different concentrations of fetal bovine serum, HPS and HPL. In vivo, we created corneal wounds on Sprague Dawley rats with a rotating burr and evaluated the effects of topical HPL on wound healing and corneal nerve regeneration by in vivo confocal microscopy and corneal aesthesiometry.

Results

HPLs had significantly higher concentrations of various neurotrophic factors compared with HPS (p<0.05). In Neuro-2a cells, 3% HPL was better at promoting neuronal growth and differentiation compared with HPS at the same concentration. HPL was also found to have superior neurotrophic effects compared with HPS in primary cultures of mouse trigeminal ganglion cells. In vivo, HPL-treated eyes had better corneal epithelial wound healing rate, nerve regeneration length and corneal touch threshold compared with eyes treated with artificial tears (p<0.05).

Conclusion

HPL has significantly higher concentrations of neurotrophic factors compared with HPS. It showed not only in vitro but also in vivo corneal neurotrophic abilities. Our results suggest that HPL may have a potential role in the treatment of diseases related to corneal nerve damage or degeneration.
Multimodal evaluation of central and peripheral alterations in Stargardt disease: a pilot study
Authors: Arrigo Alessandro , Grazioli Alessio , Romano Francesco , Aragona Emanuela , Marchese Alessandro , Bordato Alessandro , Di Nunzio Carlo , Sperti Andrea , Bandello Francesco , Parodi Maurizio Battaglia
Published: November 2019

Background

The clinical phenotype of Stargardt disease (STGD) can be extremely heterogeneous, with variable macular and peripheral retinal involvement. The study aim was to correlate peripheral ultrawide field (UWF) involvement with macular alterations, as assessed by structural optical coherence tomography (OCT) and OCT angiography (OCTA), in order to identify potentially different phenotypes.

Methods

The study involved patients with STGD and healthy controls. We performed a complete ophthalmologic assessment and multimodal imaging, including OCT, OCTA, fundus autofluorescence and UWF imaging. Patients with STGD were subdivided according to the peripheral involvement. OCT and OCTA quantitative parameters were analysed. The main outcome of the study was the classification of UWF subtypes and the correlation between UWF subtypes and macular involvement.

Results

Seventy STGD eyes (19 male; mean age 41.3±13.2 years) and 70 healthy eyes (35 male; 50%; mean age 41.2±9.8 years) were included in the analyses. Mean best-corrected visual acuity was 0.60±0.45 LogMAR for the STGD group and 0.0±0.0 LogMAR for controls (p<0.01). All clinical and imaging findings proved to be statistically worse in patients with STGD than in the control subjects (p<0.01). UWF types were distributed as follows: type I (49%), type II (34%), type III (17%). Type III patients proved to be significantly worse in terms of visual function and OCT and OCTA imaging parameters.

Conclusions

The UWF autofluorescence performed in the present study suggests that there exist three different STGD phenotypes. Each phenotype is associated with variable OCT and OCTA impairment. Further studies providing a better assessment of the peripheral retinal involvement in STGD are warranted.
Does telephone-delivered exercise advice and support by physiotherapists improve pain and/or function in people with knee osteoarthritis? Telecare randomised controlled trial
Authors: Hinman Rana S , Campbell Penny K , Lawford Belinda J , Briggs Andrew M , Gale Janette , Bills Caroline , Kasza Jessica , Harris Anthony , French Simon D , Bunker Stephen J , Forbes Andrew , Bennell Kim L
Published: November 2019

Objective

Evaluate a physiotherapist-led telephone-delivered exercise advice and support intervention for people with knee osteoarthritis.

Methods

Participant-blinded, assessor-blinded randomised controlled trial. 175 people were randomly allocated to (1) existing telephone service (≥1 nurse consultation for self-management advice) or (2) exercise advice and support (5–10 consultations with a physiotherapist trained in behaviour change for a personalised strengthening and physical activity programme) plus the existing service. Primary outcomes were overall knee pain (Numerical Rating Scale, range 0–10) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, range 0–68) at 6 months. Secondary outcomes, cost-effectiveness and 12-month follow-up were included.

Results

165 (94%) and 158 (90%) participants were retained at 6 and 12 months, respectively. At 6 months, exercise advice and support resulted in greater improvement in function (mean difference 4.7 (95% CI 1.0 to 8.4)), but not overall pain (0.7, 0.0 to 1.4). Eight of 14 secondary outcomes favoured exercise advice and support at 6 months, including pain on daily activities, walking pain, pain self-efficacy, global improvements across multiple domains (overall improvement, improved pain, improved function and improved physical activity) and satisfaction. By 12 months, most outcomes were similar between groups. Exercise advice and support cost $A514/participant and did not save other health service resources.

Conclusion

Telephone-delivered physiotherapist-led exercise advice and support modestly improved physical function but not the co-primary outcome of knee pain at 6 months. Functional benefits were not sustained at 12 months. The clinical significance of this effect is uncertain.

Trial registration number

Australian New Zealand Clinical Trials Registry (#12616000054415).
The care and transport of trauma victims by layperson emergency medical systems: a qualitative study in Delhi, India
Authors: Bhalla Kavi , Sriram Veena , Arora Radhika , Ahuja Richa , Varghese Mathew , Agrawal Girish , Tiwari Geetam , Mohan Dinesh
Published: November 2019

Introduction

Ambulance-based emergency medical systems (EMS) are expensive and remain rare in low- and middle-income countries, where trauma victims are usually transported to hospital by passing vehicles. Recent developments in transportation network technologies could potentially disrupt this status quo by allowing coordinated emergency response from layperson networks. We sought to understand the barriers to bystander assistance for trauma victims in Delhi, India, and implications for a layperson-EMS.

Methods

We used qualitative methods to analyse data from 50 interviews with frontline stakeholders (including taxi drivers, medical professionals, legal experts and police), one stakeholder consultation and a review of documents.

Results

Respondents noted that most trauma victims in Delhi are rapidly brought to hospital by bystanders, taxis and police. While ambulances are common, they are primarily used for interfacility transfers. Entrenched medico-legal practices result in substantial police presence at the hospital, which is a major source of harassment of good Samaritans and interferes with patient care. Trauma victims are often turned away by for-profit hospitals due to their inability to pay, leading to delays in treatment. Recent policy efforts to circumscribe the role of police and force for-profit hospitals to stabilise patients appear to have been unsuccessful.

Conclusions

Existing healthcare and medico-legal practices in India create large systemic impediments to improving trauma outcomes. Until India’s ongoing health and transport sector reforms succeed in ensuring that for-profit hospitals reliably provide care, good Samaritans and layperson-EMS providers should take victims with uncertain financial means to public facilities. To avoid difficulties with police, providers of a layperson-EMS would likely need official police sanction and carry visible symbols of their authority to provide emergency transport. Delhi already has several key components of an EMS (including dispatcher coordinated police response, large ambulance fleet) that could be integrated and expanded into a complete system of emergency care.
One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)
Authors: Cunningham Steve , Graham Catriona , MacLean Morag , Aurora Paul , Ashworth Michael , Barbato Angelo , Calder Alistair , Carlens Julia , Clement Annick , Hengst Meike , Kammer Birgit , Kiper Nural , Krenke Katarzyna , Kronfeld Kai , Lange Joanna , Ley-Zaporozhan Julia , Nicholson Andrew G , Reu Simone , Wesselak Traudl , Wetzke Martin , Bush Andrew , Schwerk Nicolaus , Griese Matthias
Published: November 2019

We performed a prospective, observational, cohort study of children newly diagnosed with children’s interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3–7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO2) median 92% (IQR 88–96). Death (n=20, 16%) was the most common in those <6 months of age with SpO2<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8–12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.
Investigation on structural, electronic, magnetic and thermodynamic properties of antiperovskites Mn3XC (X=Al, Zn and Ga)
Authors: Hoat D. M.
Published: November 2019

The structural, electronic, magnetic properties of Mn3XC (X[Formula: see text]=[Formula: see text]Al, Zn and Ga) antiperovskites have been investigated using first principles calculations based on Full-Potential Linearized Augmented Plane-Wave (FP-LAPW) method. Generalized Gradient Approximation with parameterization by Perdew (GGA-PBESol) is used to take into account the electron exchange–correlation interaction. Structural optimization is performed by fitting calculated data (energy-volume) to Birch–Murnaghan equation of state. Lattice constants increase in the order Mn3AlC[Formula: see text][Formula: see text][Formula: see text]Mn3GaC[Formula: see text][Formula: see text][Formula: see text]Mn3ZnC. Electronic results show that there is no bandgap near the Fermi level. While the magnetism in these compounds is derived mainly from Mn atom. Finally, thermodynamic properties, including bulk modulus, heat capacities, thermal expansion and Grüneisen parameter, are computed using quasi-harmonic Debye model and analyzed in detail.
Corrole basicity in the excited states: Insights on structure–property relationships
Authors: Kruk Mikalai M. , Klenitsky Dmitry V. , Gladkov Lev L. , Maes Wouter
Published: November 2019

Steady-state fluorescence measurements and quantum-chemical DFT geometry optimizations are applied to extend the structure–property relationships between the free-base corrole macrocycle conformation and its basicity to the lowest excited S[Formula: see text] and T[Formula: see text] states. Direct basicity estimation in the lowest excited S[Formula: see text] state is demonstrated by means of fluorescence quantum yield measurements. The long wavelength T1 tautomer is found to retain its basicity in the S[Formula: see text] state, whereas the short wavelength T2 tautomer shows a noticeable decrease in basicity in the S[Formula: see text] state, which is related to the in-plane tilting of the pyrrole ring to be protonated. The conformational changes upon going from the ground to the lowest excited T[Formula: see text] state and the influence of the meso-aryl substitution pattern on the overall degree of distortions and tilting of the pyrrole ring to be protonated are also discussed from the point of view of macrocycle basicity.
Coefficient estimates of certain subclasses of analytic functions associated with Hohlov operator
Authors: Gochhayat P. , Prajapati A. , Sahoo A. K.
Published: November 2019

A typical quandary in geometric functions theory is to study a functional composed of amalgamations of the coefficients of the pristine function. Conventionally, there is a parameter over which the extremal value of the functional is needed. The present paper deals with consequential functional of this type. By making use of Hohlov operator, a new subclass [Formula: see text] of analytic functions defined ins the open unit disk is introduced. For both real and complex parameter, the sharp bounds for the Fekete–Szegö problems are found. An attempt has also been taken to found the sharp upper bound to the second and third Hankel determinant for functions belonging to this class. All the extremal functions are express in term of Gauss hypergeometric function and convolution. Finally, the sufficient condition for functions to be in [Formula: see text] is derived. Relevant connections of the new results with well-known ones are pointed out.
The ubiquity of large graphs and surprising challenges of graph processing
Authors: Sahu Siddhartha , Mhedhbi Amine , Salihoglu Semih , Lin Jimmy , Özsu M. Tamer
Published: November 2019

Graph processing is becoming increasingly prevalent across many application domains. In spite of this prevalence, there is little research about how graphs are actually used in practice. We conducted an online survey aimed at understanding: (i) the types of graphs users have; (ii) the graph computations users run; (iii) the types of graph software users use; and (iv) the major challenges users face when processing their graphs. We describe the participants' responses to our questions highlighting common patterns and challenges. We further reviewed user feedback in the mailing lists, bug reports, and feature requests in the source repositories of a large suite of software products for processing graphs. Through our review, we were able to answer some new questions that were raised by participants' responses and identify specific challenges that users face when using different classes of graph software. The participants' responses and data we obtained revealed surprising facts about graph processing in practice. In particular, real-world graphs represent a very diverse range of entities and are often very large, and scalability and visualization are undeniably the most pressing challenges faced by participants. We hope these findings can guide future research.
Clustering uncertain graphs
Authors: Ceccarello Matteo , Fantozzi Carlo , Pietracaprina Andrea , Pucci Geppino , Vandin Fabio
Published: November 2019

An uncertain graph 𝒢 =
(V, E, p
:
E
→ (0, 1]) can be viewed as a probability space whose outcomes (referred to as
possible worlds
) are subgraphs of 𝒢 where any edge
e
ε
E
occurs with probability
p
(
e
), independently of the other edges. These graphs naturally arise in many application domains where data management systems are required to cope with uncertainty in interrelated data, such as computational biology, social network analysis, network reliability, and privacy enforcement, among the others. For this reason, it is important to devise fundamental querying and mining primitives for uncertain graphs. This paper contributes to this endeavor with the development of novel strategies for clustering uncertain graphs. Specifically, given an uncertain graph 𝒢 and an integer
k
, we aim at partitioning its nodes into
k
clusters, each featuring a distinguished center node, so to maximize the minimum/average connection probability of any node to its cluster's center, in a random possible world. We assess the NP-hardness of maximizing the minimum connection probability, even in the presence of an oracle for the connection probabilities, and develop efficient approximation algorithms for both problems and some useful variants. Unlike previous works in the literature, our algorithms feature provable approximation guarantees and are capable to keep the granularity of the returned clustering under control. Our theoretical findings are complemented with several experiments that compare our algorithms against some relevant competitors, with respect to both running-time and quality of the returned clusterings.
Lusail
Authors: Abdelaziz Ibrahim , Mansour Essam , Ouzzani Mourad , Aboulnaga Ashraf , Kalnis Panos
Published: November 2019

The RDF data model allows publishing interlinked RDF datasets, where each dataset is independently maintained and is queryable via a SPARQL endpoint. Many applications would benefit from querying the resulting large, decentralized, geo-distributed graph through a federated SPARQL query processor. A crucial factor for good performance in federated query processing is pushing as much computation as possible to the local endpoints. Surprisingly, existing federated SPARQL engines are not effective at this task since they rely only on schema information. Consequently, they cause unnecessary data retrieval and communication, leading to poor scalability and response time. This paper addresses these limitations and presents
Lusail
, a scalable and efficient federated SPARQL system for querying large RDF graphs that are geo-distributed on different endpoints. Lusail uses a novel query rewriting algorithm to push computation to the local endpoints by relying on information about the RDF instances and not only the schema. The query rewriting algorithm has the additional advantage of exposing parallelism in query processing, which Lusail exploits through advanced scheduling at query run time. Our experiments on billions of triples of real and synthetic data show that Lusail outperforms state-of-the-art systems by orders of magnitude in terms of scalability and response time.
Design Tradeoff of Hot Carrier Immunity and Robustness in LDMOS with Grounded Gate Shield
Authors: Mo Haifeng , Zhang Yaohui , Song Helun
Published: November 2019

LDMOS devices with grounded gate shield structures variations were simulated and tested, aiming to address hot carrier immunity and robustness concurrently. Optimal configuration of grounded gate shield structure was found to reduce local electrical field strength at gate-to-drain overlap for better hot carrier immunity, and to achieve uniform E-field distribution on drain side for robustness as well. Design trade off of hot carrier immunity (HCI) and robustness is analyzed by simulation and silicon data.
Pressure Analysis for Volume Fracturing Vertical Well considering Low-Velocity Non-Darcy Flow and Stress Sensitivity
Authors: Wu Zhongwei , Cui Chuanzhi , Trivedi Japan , Ai Ning , Tang Wenhao
Published: November 2019

In general, there is stress sensitivity damage in tight reservoirs and fractures. Furthermore, the flow in tight reservoirs is the low-velocity non-Darcy flow. Currently, few researches of pressure analysis for volume fracturing vertical well are conducted simultaneously considering the low-velocity non-Darcy flow and stress sensitivity. In the paper, a novel flow model of a volume fractured vertical well is proposed and solved numerically. Firstly, the threshold pressure gradient, permeability modulus, and experimental data are, respectively, utilized to characterize the low-velocity non-Darcy flow, matrix stress sensitivity, and fracture stress sensitivity. Then, a two-region composite reservoir is established to simulate the vertical well with volume fracturing. After that, the logarithm meshing method is used to discrete the composite reservoir, and the flow model is solved by the method of finite difference and IMPES. Finally, the model verification is conducted, and the effects of the low-velocity non-Darcy flow and stress sensitivity on the pressure and pressure derivative are analyzed. The six flow regimes are identified by the dimensionless pressure and pressure derivative curve. They are, respectively, the fracture linear flow regime, early transition flow regime, radial flow regime, crossflow regime, advanced transition flow regime, and boundary controlling flow regime. The stress sensitivity and threshold pressure gradient have a great effect on the dimensionless pressure and pressure derivative. With the increase of reservoir stress sensitivity, the pressure and pressure derivative are upward at the advanced transition flow and boundary controlling regimes. However, the pressure and pressure derivative are downward at the advanced transition flow and boundary controlling regimes when the fracture sensitivity increases. An increase in the threshold pressure gradient results in a high dimensionless pressure and pressure derivative. This work reveals the effects of low-velocity non-Darcy flow and stress sensitivity on pressure and provides a more accurate reference for reservoir engineers in pressure analysis when developing a tight reservoir by using the volume fracturing vertical well.
Ground Attack Strategy of Cooperative UAVs for Multitargets
Authors: Zhang Qirui , Wei Ruixuan
Published: November 2019

Humans have a fundamental ability, that is, to share vision among each other to fulfill common goals, which cooperative UAVs do not have. The difficulties mainly lie in the homologous mathematical description of humans and elusive experimental practice. This paper proposed a parallel multiview splicing on clouds, which first review both theory and practice studies in UAVs. These terms are then reconsidered from humans’ vision sharing. Next, a conceptual model of parallel multiview splicing on clouds is proposed and the mathematical deduction if fulfilled. Furthermore, an experimental cooperative UAVs platform is built to practically implement the algorithms. Both the simulated and practiced results have validated the feasibility of our method. Finally, a general discussion and proposals for addressing future issues are given.
Black Esophagus in the Setting of Diabetic Ketoacidosis: A Rare Finding from Our Institution
Authors: Ghoneim Sara , Shah Aun , Dalal Shaman , Landsman Marc , Kyprianou Annette
Published: November 2019

Acute esophageal necrosis (AEN) is defined as necrosis of the esophageal mucosa seen as diffuse black discoloration of the distal esophagus on an upper endoscopy. The prevalence of the disease is rare and reported to be up to 0.2% in autopsy series. The etiology of the disease is thought to be multifactorial and due to ischemic insults to the esophagus with gastric acid reflux further damaging the vulnerable mucosa. Patients are often critically ill or with significant comorbidities. Here, we present a case series of 3 patients with AEN induced by diabetic ketoacidosis.
Intra-hospital complications in acute traumatic spinal cord injury
Authors: Leite Victor Figueiredo , Souza Daniel Rubio de , Imamura Marta , Battistella Linamara Rizzo
Published: November 2019

There is scarce data about intra-hospital complications in acute traumatic spinal cord injury (TSCI). Objective: To report characteristics of complications in patients with TSCI in a major trauma center. Method: This is a cross-sectional study with 434 patients with acute TSCI from 2004 to 2014. Outcomes were frequency and description of complications, length of hospital stay (LOS), and causes of increased LOS. Results: Patients presented at least 1 complication in 82.2% of the cases: urinary tract infection (UTI) = 64.4%, pressure ulcers (PU) = 50.6%, and pneumonia = 23.7%. Pneumonia, intubation and cases of surgical corrections for PU were independently associated with increased LOS. Conclusion: UTIs and PUs were the most frequent complications. Investigating its causes and consequences is paramount in the care of patients with SCI. Possible reasons for such complications could comprise time, and frequency of repositioning in bed. Investigating intra-hospital complications is paramount in SCI centers.
A prática da capoeira por pessoas com síndrome de Down
Authors: Teixeira Barbara Vilar , Mota Cristiane Gonçalves da
Published: November 2019

A Síndrome de Down (SD) é caracterizada pela presença de um cromossomo 21 extra, o que estabelece atraso no desenvolvimento psicomotor. A capoeira é uma prática corporal que tem como principal característica o controle do corpo, realizada por meio de atividades de coordenação motora, resistência aeróbia e muscular, ritmo e velocidade. Programas de atividade física como a capoeira, adaptada às pessoas com síndrome de Down, buscam auxiliar no desenvolvimento ou na melhora das capacidades físicas e habilidades motoras de seus praticantes. Objetivo: Encontrar estudos que propuseram a prática da capoeira por pessoas com SD, e verificar quais os resultados alcançados. Métodos: Foram realizadas pesquisas nas bases de dados Medline, SciELO, PUBMED, Lilacs, Bireme e Dedalus. Os descritores utilizados foram: síndrome de Down, deficiência intelectual, capoeira, atividade física, nos idiomas português e inglês, além de livros com publicações no período de 2007-2014. Resultados: Nove artigos incluídos nessa revisão da literatura. Conclusão: Verificou-se que as pessoas com síndrome de Down que praticavam capoeira obtiveram melhora no equilíbrio postural, coordenação motora e cognição e que também, essas pessoas tornaram-se mais independentes nas atividades cotidianas.
Perfil da resiliência em indivíduos com amputação de membro inferior
Authors: Paz Maressa Gonçalves da , Souza Juliana Caldas de , Oliveira Fernanda Miranda de
Published: November 2019

Objetivo: Identificar o perfil sociodemográfico dos amputados de membro inferior bem como, os níveis e os fatores da resiliência. Método: Trata-se de um estudo descritivo, quantitativo e transversal. Os dados foram coletados através de um questionário semiestruturado após aprovação pelo Comitê de Ética e Pesquisa. O período de coleta foi entre Setembro a Novembro de 2017 no ambulatório do Centro Estadual de Reabilitação e Readaptação de Goiânia – Goiás. Os dados foram apresentados em frequências, média e desvio padrão. Resultados: Verificou-se que os indivíduos resilientes tinham amputação acima do joelho (44%), de etiologia traumática (30,1%), não receberam orientação após a amputação (41,5%) e utilizam as muletas como principal dispositivo auxiliar na locomoção (49%). Houve uma predominância da resiliência moderada 33 (62,2%) e de respostas do tipo concordo para os fatores I e III da escala de resiliência. Para o fator II houve semelhança nas respostas do tipo nem concordo e nem discordo e do tipo concordo. Discussão: Amputação acima do nível do joelho, etiologia traumática e ausência de orientação quanto aos cuidados com o coto foram predominantes nos indivíduos resilientes tais características estão associadas a um maior grau de incapacidade, cuidados inadequados com o coto, stress e depressão. Acredita-se que condições adversas pode influenciar positivamente a resiliência graças a capacidade de ajustamento e adaptação do indivíduo. Conclusão: A resiliência moderada evidencia que os amputados possuem estratégias de enfretamento positivas, porém e necessário realizar programas de treinamento a fim de promover melhor independência e determinação.
Qualidade de vida e avaliação antropométrica de professores de uma rede privada de ensino
Authors: Oliveira Marcia Maria Hernandes de Abreu , Freitas Bruna Andrade , Silva Keliane Galdino , Furgêncio Gislene Kauffman , Portes Leslie Andrews , Kutz Nyvian Alexandre
Published: November 2019

Objetivo: Avaliar a associação entre a qualidade de vida (QV) e parâmetros antropométricos e de docência, de professores de uma rede privada de ensino de São Paulo. Métodos: Realizou-se estudo transversal descritivo com 107 professores, utilizando-se dois questionários autoaplicáveis, abordando aspectos sociodemográficos, variáveis da docência e de QV (World Health Organization Quality on Life Bref - WHOQOL-bref). Após o preenchimento, os sujeitos foram submetidos às medidas de peso, estatura, índice de massa corporal (IMC) e circunferência da cintura (CC). Resultados: Os professores tinham idade média de 38,2 ± 8,6 anos, 78,5% do sexo feminino, 78,5% casados, 74,8% pertencente à classe B. Todos os professores possuíam ensino superior completo, 64,5% até 10 anos de atuação, 88,8% trabalhavam mais de 20h/semana, 44,9% atuavam em dois turnos ou mais, 55,1% encontravam-se com excesso de peso, 71,1% em risco para doença metabólica e 84,1% consideravam sua QV boa ou muito boa. Nenhuma das variáveis antropométricas, de tempo de docência, de carga horária e da classe econômica, correlacionarem-se significantemente à QV. Correlações fracas, mas significantes, foram observadas entre o tempo de docência e IMC e CC (r=0,26 e r=-0,22, p<0,05). Contudo, verificou-se significante associação (p<0,05) da QV (<71pontos: 35,6±7,9anos vs. ³71pontos: 40,0±9,0anos) com a idade, do IMC (<25kg/m2: 59,0±7,4kg vs. ³25kg/m2: 80,3±15,0kg) com o peso e a circunferência da cintura (<25kg/m2: 80,6±6,9cm vs. ³25kg/m2: 95,9±10,5cm). Conclusão: Embora a percepção da QV seja satisfatória, ela não se relacionou às variáveis antropométricas, sociodemográficas e de docência. Porém, o tempo de docência relacionou-se significantemente ao IMC e à CC.