bluuebunny/crossref_metadata_2025 huggingface dataset:
Mapping of scientific production on actions, projects and challenges to deal with fresh water scarcity
Authors: Endo Gustavo Yuho , Leite Junior José Hugo , Lenzi Giane Gonçalves , Kovaleski João Luiz
Published: November 2023

The concern over water is due to the increase in population, which has led to an increase in water consumption. Given the context of water scarcity, it is necessary to direct efforts towards preventing this occurrence. One way to meet demand is through technology for water reuse. In this sense, the research proposal was to conduct a systematic and integrative review of the literature on technology transfer related to water, with a focus on water reuse. A total of 33 articles on the subject were selected. The main findings were that research is focused on promoting water reuse and addressing concerns about water consumption. The research highlights the importance of public policies related to water consumption and reuse, as well as the need to understand the population's awareness and acceptance of such aspects. One alternative to meet the water scarcity crisis is through desalination, but progress is needed to overcome the barrier of high energy consumption and waste generation. Regarding technology transfer, sharing knowledge on a global level is necessary for effective technology transfer and satisfactory results.
Abordagem para eliminar anomalias no processo de fabricação de chicotes elétricos – estudo de caso de verticalização de processos
Authors: Mendonça Gleidson Moraes
Published: November 2023

A verticalização de processos torna-se a opção mais viável para uma organização sistemista do polo duas rodas de Manaus, quando seus fornecedores não se sustentam no mercado acabam gerando a necessidade constante de substituição, desta forma este case apresenta além do aspecto de troca de fornecedores, os elevados índices de anomalias mensuráveis e imensuráveis que contribuem para transtornos internos e em seus clientes, que geram retrabalho e custos ao longo de 8 anos. Com o objetivo geral desenvolver as melhores condições para internalizar (verticalizar) a fabricação de chicotes elétricos, um time multifuncional desenvolveu análise aprofundada, buscando entender melhor as justificativas apresentadas pelos fornecedores para as anomalias, que repousavam sempre sobre a mão de obra, sendo assim identificado que, se os métodos fossem melhor planejados boa parte dos problemas seriam eliminados. Tal esforço tem como objetivos específicos investigar e classificar as causas históricas das anomalias nos fornecedores e implementar as ações de melhorias na definição dos processos internos para corte e decape dos cabos e posterior fixação (aplicação) dos terminais nestes cabos. Além de redefinir os métodos, os investimentos em máquinas e equipamentos foram direcionados ao propósito de que eles garantissem o mínimo de interferência manual principalmente para o processo de aplicação de terminal no cabo elétrico. O plano se estabelece e a análise crítica dos processos externos proporcionam escolhas que unem tanto corte e decape de cabos como aplicação de terminais em uma única máquina e sem a interferência manual para que ambos os processos se completem a cada peça fabricada, além da análise metalográfica desenvolvida em equipamento de uso exclusivo para este tipo de produto.
Simulador de processos produtivos – Praxis
Authors: Olivares Gustavo Lopes , Passalini Amanda Aparecida , Azevedo Filho Edson
Published: November 2023

A Educação no Brasil, na maioria de nossas escolas, ainda é baseada no ensino convencional, utilizando recursos conservadores como lousas e aula expositiva. Nas Instituições de Ensino Superior (IES) isso não é muito diferente, metodologias e técnicas de ensino pautadas na reprodução e transmissão de conteúdos que culminam na passividade acrítica e arreflexiva por parte de quem aprende. No sentido de contribuir para a melhoria do processo de ensino e aprendizagem, este trabalho desenvolveu o método integrativo (MINT). O MINT é um ambiente simulado que conjuga elementos da teoria da gamificação, aprendizagem vivencial e de metodologias ativas. O método proposto integra os conceitos maker, designer e de empreender. Utiliza recursos tecnológicos juntamente com a dinâmica de um jogo de tabuleiro. Esse ambiente foi intitulado de praXis (simulador de processos produtivos), ainda está sendo aprimorado e a versão beta do software (chamado de plataforma) já foi testada por dois anos em turmas de graduação em administração, graduação de engenharia de produção e uma turma de pós-médio do curso de logística. Os resultados são significativos e apontam o praXis como um recurso didático que favorece a aprendizagem, permitindo a prática de conceitos básicos de gestão organizacional.
Hairy roots as a potential source for the production of rosmarinic acid from genus Salvia
Authors: Shriti Somani , Kuldeep Prasad Agarwala , Narasimha Sudheer Wudali , Praveen Nagella
Published: November 2023

The Salvia genus, a member of the Lamiaceae family, exhibits a rich array of secondary metabolites, including di- and triterpenoids, phenols, polyphenols, and essential oil compounds. These constituents contribute to valuable pharmacological activities such as antibacterial, antiviral, anti-inflammatory, and antioxidant properties. Among these metabolites, rosmarinic acid stands out as a particularly promising compound, deriving from the precursors phenylalanine and tyrosine. It belongs to the phenolic compound class and acts as an ester of caffeic acid, showcasing diverse therapeutic potentials like antifungal, antibacterial, antiviral, antioxidant, anticancer, anti-ageing, anti-inflammatory, and anti-diabetic effects. To facilitate the production of such secondary metabolites, plant tissue culture techniques have played a pivotal role, with hairy root cultures being one of the preferred methods. This review provides an extensive examination of the biosynthetic pathway of rosmarinic acid and its successful generation using hairy root cultures. Additionally, the review highlights the utilization of genetic modification tools and various biotic and abiotic elicitors, including yeast extract, methyl jasmonate, and silver ion (Ag+), in hairy root cultures of diverse Salvia species to enhance the production of rosmarinic acid.
longitudinal investigation of connectedness and syntactic complexity in the written production of bilingual children during the COVID-19 pandemic
Authors: Ely Lemke Cristiane , Da Silva Cury Larissa , Weissheimer Janaína , Bezerra Mota Natália , Finger Ingrid
Published: November 2023

The present study aimed at investigating, in a longitudinal way, connectedness and syntactic complexity in written narratives in Portuguese (L1) and English (L2) produced by 5th and 6th grade children enrolled in a bilingual school. For the evaluation of connectedness (thought organization), we used the computational tool SpeechGraphs (MOTA et al., 2012, 2016, 2019); syntactic complexity was verified through the analysis of T-Units and the Subordination Index (HUNT, 1965). Children were asked to write narratives in both languages based on sequences of pictures twice, first in August 2020 and then in August 2021. The longitudinal analysis showed that children wrote more syntactically complex texts in Portuguese, their L1, in both phases of data collection. In addition, they also wrote more connected narratives (LSC – long-range recurrence) and more syntactically complex texts in Portuguese in 2021, in comparison to 2020. With respect to their L2, however, no significant growth was perceived in the connectedness or complexity scores, which could also be interpreted as an effect of the pandemic on the development of students' L2 writing, since children had significantly fewer opportunities to interact in English in online classes, which may have impacted their development of productive skills in their L2.
Ekstraksi Topik Pantun di Twitter Menggunakan K-Means Clustering
Authors: Ulinnuha Nurissaidah , Indriyani Jiphie Gilia
Published: November 2023

Pantun is an old form of poetry in Indonesia. Over time, the anxiety of the existence of rhymes in society has become the anxiety of literary, language and cultural activists. This study aims to explore the existence of the use of rhymes on social media which was highly encouraged by young people in the era of Society 5.0. There are two types of rhymes studied, namely general and islamic rhymes. The method used is K-Means clustering analysis to find rhyme topics that are often used in social media. The general category of pantun cluster structure belongs to the weak structure because the silhouette coefficient values are in the range of 0.26-0.5 while the Islamic pantun group structure belongs to the good too strong structure because the silhouette coefficient values are in the range of 0.4-0.9. It was found that the general category of rhymes were still widely used on social media with the type of theme being youth rhymes. The purpose of using the rhyme is more dominant to express feelings. On the other hand, the islamic category of rhymes is rarely used on social media with the type of theme being parental rhymes. The purpose of using the rhyme is more dominant to religious symbols.
Masculinidades e intimidades literarias en México durante el siglo XX
Authors: Comite Editorial
Published: November 2023

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Imaginarios y racialización en contextos poscoloniales. Latinoamérica, Caribe, Norteamérica
Authors: Catelli Laura
Published: November 2023

Cuando se convocó a enviar colaboraciones para este número, el objetivo central que se planteó fue impulsar un debate sobre la racialización en la larga duración de la modernidad/colonialidad de Latinoamérica, el Caribe y Norteamérica. La idea no era tanto lograr una representación geográfica e histórica cabal del problema, más bien se pretendía dar lugar, aprovechando el formato colectivo propiciado por el dossier, a un ensamblaje transdisciplinario de lecturas y análisis críticos de los efectos racializantes de lo que en la convocatoria describí como formaciones imaginarias en contextos poscoloniales.
Necropolítica en Chambacú, corral de negros de Manuel Zapata Olivella
Authors: Aguía Betancourt Nicolás
Published: November 2023

En el presente artículo se propone una lectura de la novela Chambacú, corral de negros, del escritor colombiano Manuel Zapata Olivella, desde el concepto de necropolítica explicado por el filósofo Achille Mbembe, para pensar el territorio del barrio cartagenero de Chambacú como una “zona de excepción” en la que deja de imperar el régimen ordinario de la ley. A su vez, se plantea que los mecanismos de terror del gobierno contra los habitantes afrocolombianos del barrio reinscriben las jerarquías coloniales. En la novela, la lucha de los chambaculeros por el territorio ofrece una oportunidad de emancipación política.
Feeling the Truth: Emotions and Digital Truth-making within Right-wing Populist Networks on Twitter/X
Authors: Schramm Pia , Schramm Pia , Molin Julia
Published: November 2023

Based on an investigation of how everyday users participate in right-wing populist discourse on social media platforms, this article explores the emotional practices that shape and legitimise purported truths about the threat posed by Islam to the Western world. The article builds on the findings of an online ethnography of a right-wing community of users on Twitter. Drawing on a practice theory approach of emotions that considers the properties of social media platforms, we argue that right-wing populist claims to truth do not function in a linear way. The emotions mobilised in this context do not solely focus on rejection and exclusion. Rather, right-wing populist truth-making is a complex process in which emotional practices of inclusion and exclusion are interwoven. 
Avrupa Birliği ve Türkiye’de Tarımsal Sürdürülebilirlik: Malmquist Endeksi Analizinden Çıkarımlar
Authors: Yeni Onur , Teoman Özgür
Published: November 2023

Bu çalışmanın temel amacı, 2008-2019 dönemi için Türkiye tarım sektörünün sürdürülebilirliğinin AB üyesi ülkelerin tarım sektörleri ile karşılaştırmalı olarak incelenmesidir. Bu amaçla çalışmada Malmquist endeksi yönteminden yararlanılmaktadır. Söz konusu yöntem, çok girdili ve çok çıktılı bir üretim teknolojisinin modellenmesine olanak sağlamaktadır. Yapılan analizde altı adet girdi değişkeni (tarımsal arazi, emek, net sermaye stoku, tarım ilacı, kimyasal gübre, enerji) ve üç adet çıktı değişkeni (tarımsal katma değer, gıda güvenliği ve sera gazı salımı) kullanılmaktadır. Çalışmanın ana bulguları AB ülkeleri (ortalama) ve Türkiye’de 2008-2019 döneminde toplam faktör verimliliğinin (TFV) sırasıyla %1 ve %1.4 arttığını göstermektedir. Bu artış ise temel olarak teknolojik değişmeden kaynaklanmaktadır. Bu bulgular, ilgili dönemde tarımsal sürdürülebilirlik açısından Türkiye ile AB ülkeleri arasında bir yakınsamaya işaret etmektedir. Bununla birlikte, Avrupa çapında kuraklık yılı olarak belirtilen 2016 yılı dışarıda bırakıldığında Türkiye’de 2008-2011 dönemi ile 2013-2019 dönemi TFV ortalamaları karşılaştırıldığında Türkiye’nin anılan ikinci dönemde daha yüksek bir TFV artışı yaşadığı görülmektedir.
Is the Stick Real? Trends from Concluded Prosecutions of Industrial Environmental Crimes in South Africa
Authors: Strydom Melissa , Field Tracy-Lynn
Published: November 2023

South Africa’s suite of environmental laws contains many criminal sanctions and penalty provisions. Whether the criminal sanction is an effective tool that realises the constitutionally protected environmental right depends on how it is practically enforced and whether potential offenders become aware of such enforcement measures. This article reports on research aimed at collecting and analysing prosecutions for industry-related transgressions (conducted mainly in Magistrate’s Courts) and involving offences under the National Environmental Management Act (NEMA), the Waste Act, the Air Quality Act and the National Water Act. An analysis of 53 prosecutions shows that most cases resulted in convictions, half were concluded through plea and sentence  agreements, half involved the conviction of individuals, no direct imprisonment penalties were imposed, and low fines  were imposed in most cases. The findings include that there is some inconsistency in how different listed activities or water uses are treated as separate or consolidated criminal charges, and the exact number, outcome or trends arising from such cases are difficult to determine as there is no central, readily accessible database of concluded prosecutions. Increased access to such information would improve knowledge, implementation and the effective use of the criminal sanction through prosecutions. In turn, this would contribute to the improved realisation of the constitutionally protected environmental right.
Legal History as the Perfect Vessel: Teaching with Infographics for the Development of Digital Visual Literacy Skills in Law Students
Authors: Bauling Andrea
Published: November 2023

Digital literacy development must be regarded equally essential as the development of other literacies and critical thinking skills in Bachelor of Laws students. Because law teachers do not include visuals in learning materials, law students do not develop the skills to effectively interpret them. Digital visual literacy (DVL) is one of the core digital literacies law teachers can advance in their students to prepare them for our visually-driven world. Legal historical course material is the perfect vessel for visual learning materials in law, as these can effectively communicate the spacio-temporal aspects of legal history and legal historical development. A recent empirical study of the views of South African students of legal history indicated their positive sentiments toward a wide variety of visual learning materials and the inclusion of instructor-generated summary infographics in online learning materials. They were also in favour of the inclusion of descriptive visuals like timeline infographics containing additional visual elements in legal historical course content. The study also indicated that reading and interpreting infographics aid the development of DVL skills, and the more infographics students interact with, the better they become at interpreting them. Since the instructor-generated summary infographic can be designed to communicate information about a specific module, it is suited to teaching any legal content. Visual learning artefacts can be created and sourced in numerous ways, but the process can be time-consuming. Sharing these amongst colleagues and institutions as open educational resources (OER) will ultimately aid a collective project aimed at the development of the DVL skills of South African law students. The article provides examples of instructor-generated summary infographics based on legal historical course content, distributed as freely available OER.
No Country for Old Women: A Critique of Grobler v Phillips 2023 1 SA 321 (CC)
Authors: Geduld Allison
Published: November 2023

Land and land rights remain a contested issue in South Africa. Grobler v Phillips centered on the eviction of an 86-year-old woman, Mrs Phillips, and her disabled son from property she had lived on since she was 11 years old. After a fourteen-year court battle the Constitutional Court granted an eviction order against Mrs Phillips. This case note consists of a discussion of the judgments of the Magistrate's Court, High Court, Supreme Court of Appeal and Constitutional Court. It is found that the Constitutional Court erred in its decision as it applied a formalistic approach, disregarded the narrative of the occupier and did not sufficiently challenge the current neo-liberal regime in which property rights operate.
Un futur qui manque: sur quelques pièces de théâtre togolaises
Authors: Jakubczuk Renata , Wołowski Witold
Published: November 2023

Les observations contenues dans le présent article concernent six pièces de théâtre togolaises strictement contemporaines (quatre miniatures dramatiques—Sous le grand kapokier… de Roger Atikpo, Jumel’âge de Jean Kantchébé, Tobbie, frères et sœurs ont la douleur de Rodrigue Norman, Tac-tic à la rue des Pinguins de Gustave Akakpo—et deux textes de dimensions normales : Atterrissage de Kangni Alem et Tanse-maître(s) d’Elemawusi Agbedjidji). Sur le plan esthétique, les analyses visent à décrire les attitudes assumées par les personnages envers le manque d’avenir qui caractérise l’univers dans lequel ils évoluent. Ces considérations s’organisent en deux sections : dans la première, nous nous focalisons sur les éléments traumatisants du passé qui rendent difficile, voire impossible, le dépassement du passé/présent vers un avenir ; dans la seconde nous analysons les éléments relatifs à l’image de l’avenir (ou de son absence) qui se dégage des textes, ainsi que les tentatives faites par les personnages pour surmonter l’apathie et l’inertie. Sur le plan théorique, nous soutenons la thèse selon laquelle, les textes étudiés constituent la preuve d’un certain échec des grandes opérations sociopolitiques et idéologiques (le système du postcolonialisme et le fétiche du développement) qui avaient pour l’objectif l’amélioration de la situation sur le continent africain, et qui sont actuellement remises en cause à travers les débats les plus récents.
Micro/nanosized ferrite and hexaferrite structures: The polyol processes for synthesis
Authors: Nguyen Viet Long , Nguyen Thi Nhat Hang , Ho Van Cuu
Published: November 2023

In this research, controlled synthesis and properties of micro/nano-sized magnetic oxide powders via a polyol process are discussed. They are the original magnetic oxides that have been studied by many scholars because of their many applications. The most special forms are the diversity of FeO and Fe2O3, and the diversity of the Fe3O4 matrix which are the most important original structures with formulas to be FeO.Fe2O3 (Fe3O4) and Fe2O3 can be oxide systems of FexOy that are very common and different. On the basis of the original structures, we can synthesize the most special forms of ferrite and hexaferrite related to the four original structures, which are AB2O4-spinel-type SrFe2O4 and BaFe2O4 ferrites (M: metal elements, Sr, Ba; B: Fe), PbFe11AlO19-type MX12O19 (M: metal elements, Sr, Ba; X: Fe) SrFe12O19 and BaFe12O19 by polyol processes and technologies. We understand that elements that form original structures are incorporated into Fe3O4 to form ferrite and hexaferrite structures, typically such as SrFe12O19 by liquid-, solid- and gas-based phase chemical reactions via the polyol processes and heat treatment processes. In the future, we suggest that the original oxide structure and formula of natural minerals can be used as the new magnetic structures and compounds.
Tail Suspension Test v1
Authors: Lorente Picón Marina
Published: November 2023

Tail Suspension Test for mice
Role of Charged Amino Acid Residues of Plastocyanin in Interaction with Cytochrome B6f Complex and Photosystem I of Higher Plants: A Study Using the Brownian Dynamics Method
Authors: Fedorov V.A. , Volkhin I.A. , Khrushchev S.S. , Antal T.K. , Kovalenko I.B.
Published: November 2023

Plastocyanin is an electron carrier protein in the electron transport chain of chloroplasts, carrying out the transfer of an electron from cytochrome f of the cytochrome b6f complex to photosystem I. Using the method of Brownian dynamics, the process of formation of the encounter complex of plastocyanin and photosystem I of higher plants was studied. The electrostatic properties of proteins were studied, and the most important amino acid residues for their interaction were identified. It was shown that plastocyanin contacts the positively charged alpha-helix protruding into the lumen of the F subunit of photosystem I with amino acid residues of both its “large” (D42, E43, D44, E45, D51) and “small” (E59, E60, D61) the negatively charged regions in 73 % of cases, and only the "large" region in 27 % of cases. A comparison of the study results with previously obtained data on the interaction of plastocyanin with cytochrome f made it possible to identify the role of charged amino acid residues of plastocyanin in the process of complex formation with photosystem I and cytochrome f. When interacting with cytochrome f, a positively charged region located near the small domain of cytochrome f and formed by amino acid residues K58, K65, K66, K187 and R209, attracts negatively charged amino acid residues D42, E43, D44, E45, D51 of the “large” region of plastocyanin, forming an electrostatic hinge contact around which rotation occurs when the final complex is formed. The “small” region of plastocyanin is involved in the stabilization of the final complex. Thus, both in the formation of the encounter complex with photosystem I, and in the reaction with cytochrome f the same negatively charged amino acid residues of plastocyanin are used.
Differences in Active Travel Between Immigrants in an Active and Less Active Mobility Culture
Authors: Faber Koen , Kingham Simon , Conrow Lindsey , Van Lierop Dea
Published: November 2023

Despite growing investments in active travel infrastructure in many developed countries, walking and cycling rates often remain low. In addition to changes in the built environment, life experiences, place-specific urban mobility policies, and social and cultural norms with regard to active travel mode use are also found to be important factors for encouraging walking and cycling. Many researchers have examined immigrants’ travel behaviour to study the influence of social and cultural norms and place-specific factors on mode choice and travel decisions. However, knowledge of the differences in walking and cycling behaviour between various sub-groups of immigrants remains limited. By means of a multiple linear regression model, this study investigates differences in walking and cycling behaviours between immigrants in a less active travel culture, namely New Zealand, and an active travel culture, the Netherlands. The findings show that immigrants in both contexts walk and cycle more than the wider populations. Analysis results demonstrate that socio-demographic characteristics, car and bicycle access, and trip purpose all have a significant effect on active travel behaviour. Furthermore, on average, Dutch born-and-raised immigrants in New Zealand cycle more days per month than professional immigrants in the Netherlands and tend to use a much wider range of transport modes, particularly sharing services. These findings suggest that past experiences with particular travel modes and socialisation factors likely play a major role in active travel behaviour, thereby stressing the need for more research on the role of cultural and social norms in travel decision-making processes.
Principles and approaches in the development of fluorescent hydrogels for cancer diagnosis
Authors: Sokolov P. M. , Samokhvalov P. S. , Baranova D. A. , Sukhanova A. V.
Published: November 2023

Introduction. Early sensitive and highly specific diagnosis is crucial for successful cancer therapy. The use of fluorescent hydrogels (FHG) makes it possible to develop versatile biosensors due to the increased binding capacity of biological capture and reporter molecules, sensitive fluorescence detection, and the flexibility of combining their structural and functional elements.

Aim. Analyzing the principles of designing biosensors based on FHG for the detection of cancer markers and the methodological approaches to their development, as well as summarizing and systematizing the data on the principles of detection and target signal generation used in these sensors.

Results. FHG represent 3D sensing platforms, i. e., structures that combine the reporter fluorescence function with biological capture molecules, allowing the unique optical properties of fluorescent nanocrystals at the macro level to be preserved. The porous structure of hydrogels increases the active surface area of biosensors for 3D immobilization of fluorescent labels and biological capture molecules, while preserving the structure of these molecules, which ensures specific binding of the detected molecules of the sample. This ensures a higher sensitivity compared with the traditional methods of immunoenzymatic and immunochromatographic analyses. Not only the traditionally used antibodies, but also enzymes and glycoproteins, aptamers and oligonucleotides, as well as polymers obtained by molecular imprinting, can serve as biological capture molecules, which extends the range of specifically detectable analytes.

Conclusion. The review presents examples of biosensors based on FHG intended for the detection of cancer markers and describes approaches to the preparation of FHG and immobilization of biological capture molecules, as well as principles of generation of the detected optical signal. The main advantages of fluorescent hydrogel biosensors over the classical tests used for quick diagnosis of cancer are shown.
Analysis of the IL-10 mRNA level in the peripheral blood of patients with cancer and benign prostatic hyperplasia
Authors: Korovin O. A. , Alyasova A. V. , Arioua Kh. M. , Novikov D. V. , Krasnogorova N. V. , Novikov V. V.
Published: November 2023

Background. Interleukin-10 (IL-10) is a pleiotropic cytokine with immunomodulatory properties and may inhibit tumor development and progression or stimulate tumor growth.

Aim. Analysis of the changes of the IL-10 mRNA level in the peripheral blood (PB) of patients with prostate cancer (PC) and benign prostatic hyperplasia (BPH) in comparison with clinical and laboratory data.

Materials and methods. 63 patients with histologically confirmed PC and 52 patients with histologically confirmed BPH were under observation. The control group consisted of 30 practically healthy persons comparable in age. Determination of the relative level of IL-10 mRNA in PB samples was performed by real-time reverse transcription polymerase chain reaction.

Results. Both in patients with PC and in patients with BPH, a statistically significant decrease in the level of IL-10 mRNA in the PB of patients was observed in comparison with the control. In PC, the lowest levels were found in patients with a prostate-specific antigen (PSA) concentration above 10 ng / l and with a prostate volume of more than 50 cm3. Differences in the level of IL-10 mRNA at T2 and T3 stages and at different testosterone concentrations were not statistically significant, although there was a pronounced downward trend in prognostically unfavorable cases. Patients with BPH had a relative level of IL-10 mRNA, which was statistically significantly higher than in patients with PC. At PSA concentrations above 10 ng / mL, the level of IL-10 mRNA was also lower than at its lower concentrations.

Conclusion. In patients with cancer and BPH, a reduced level of IL-10 mRNA was found in the PB. The decrease is more pronounced in the unfavorable course of diseases and, apparently, is a consequence of the instability of IL-10 mRNA at the post-transcriptional level.
COMPARATIVE GEOLOGICAL AND ECONOMIC ASSESSMENT OF THE TITANIUM DEPOSITS OF UKRAINE USING THE EXAMPLE OF THE NOVOMYRHOROD PLACERS DISTRICT
Authors:   Institute of Geological Sciences of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, OKHOLINA Tetiana , KUZMANENKO Halyna ,   Institute of Geological Sciences of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Published: November 2023

The article considers one of the methods of geological and economic assessment – ranking of titanium ore deposits on a point scale on the example of the Novomyrhorod placer district, which includes the Birzulivske deposit, Likarivske, Andriivske, Valuivske, Novomyrhorod placers, as well as the Eastern and Western residual areas. A brief geological description of the compared titanium objects is given, as well as the geological, qualitative and economic indicators are used to make a comparative geological and economic assessment of the studied deposits and placers. The use of a scoring scale allows comparing objects with different degrees of exploration and can be used to determine the prospects of any deposit among a number of objects with a limited amount of information.
APPLICATION OF HYDROACOUSTIC METHODS IN GEOCHEMICAL RESEARCH OF POLLUTANTS DISTRIBUTION IN THE SURFACE LAYER OF BOTTOM SEDIMENTS
Authors:   State Scientific Institution "Center for Problems of Marine Geology, Geoecology and Sedimentary Ore Formation of the NAS of Ukraine", Kyiv, Ukraine, YEMELIANOV Volodymyr , NASIEDKIN Yevhen ,   Institute of geological sciences of the NAS of Ukraine, Kyiv, Ukraine 3State Institution "Scientific Hydrophysical Center of the National Academy of Sciences of Ukraine", Kyiv, Ukraine, FEDOSEIENKOV Serhii ,   State Institution "Scientific Hydrophysical Center of the National Academy of Sciences of Ukraine", Kyiv, Ukraine, KOSHLIAKOVA Tetiana ,   M. P. Semenenko Institute of Geochemistry, Mineralogy and Ore Formation of the NAS of Ukraine, Kyiv, Ukraine
Published: November 2023

The article presents the results obtained during the long-term field studies of the characteristics of the sedimentary matter metal-containing component distribution within the territories of industrial cities, in particular, Zaporizhia city. Based on field contact and remote studies, one of the aspects of the problem was studied, namely the peculiarities of iron concentrations distribution in the surface layer of bottom sediments of the Dnipro river. Key practical approaches to the application of a new complex method of field observations are outlined, which combine the possibilities of express planar surveying with the determination of geochemical characteristics of river sediments. The methodology of combining contact geochemical studies of iron distribution in surface bottom sediments with the performance of a side view of a remote route survey using sonar is substantiated. Herewith, the possibility of determining the lithological differences of the surface layer of bottom sediments under the conditions of determining the average concentrations of iron for the main material types of sediments is assumed. The results of two-year research based on the data of fieldwork revealed promising perspectives for the development of such a complex of observations in the case of systematization of the direction, additional testing of the technological component in various test areas of the water area, as well as the development of an appropriate methodological foundation.
Collaborative Problem Solving in PISA Science by Pedagogical College Students
Authors: Safronova M.A. , Maksimova T.S.
Published: November 2023

The article presents pilot research in psychology and pedagogy that studies the relationship of collaborative way of problem solving by college students with the effectiveness of solving PISA science problems. The study involved 39 female students of the 1st year of the Pedagogical College (primary school teachers) in the Lipetsk region aged from 16 to 17 years (M=16.1; SD=0.5). The questionnaire of V.I. Morosanova “Style of self-regulation of behavior SSP-98”, the questionnaire of the direction of learning motivation of T.D. Dubovitskaya were used. The ascertaining experiment was conducted included three series of problem solving (individual, collaborative in groups of three, individual). The results show that in the experimental group, in which the stage of collaborative solving of PISA 2015 science problems were conducted, students of the Pedagogical College solved the final individual PISA 2006 science problems better than in the control group, in which a joint stage was not held.
Obstetric and perinatal risks after new coronavirus infection
Authors: Medyannikova Irina V. , Kuklis Yulia Ch. , Savelyeva Irina V. , Beznoshchenko Galina B. , Galyanskaya Elena G. , Tsygankova Olga Yu. , Prodanchuk Evgeny G. , Bukharova Elena A. , Nosova Natalya V. , Davydov Pavel V.
Published: November 2023

BACKGROUND:Numerous studies indicate that pregnant women are at risk for severe morbidity, adverse gestational outcomes, and mortality following COVID-19. These patients have a higher frequency of miscarriage at various stages of gestation, premature birth, preeclampsia, cesarean section, and birth of children with low body weight. Other publications have suggested that the clinical characteristics of the disease detected in pregnant women with confirmed COVID-19 are similar to those in the general population.
AIM:The aim of this study was to determine obstetric and perinatal risks in women who have had COVID-19 during pregnancy.
MATERIALS AND METHODS:We conducted an open prospective continuous cross-sectional study in which 114 patients were examined after suffering from COVID-19. Depending on the severity of the new coronavirus infection, they were divided into groups: group I (n= 36) included patients with mild disease, group II (n= 56) – with moderate disease, group III (n= 22) – with heavy. The control group consisted of 93 pregnant women who were hospitalized during the specified period without COVID-19 and signs of acute respiratory viral infection.
RESULTS:Gestational diabetes mellitus is associated with a risk of the moderate and severe new coronavirus infections during pregnancy. Placental deficiency is significantly more often recorded in moderate and severe COVID-19 cases. Severe COVID-19 in pregnant women determines a high probability of fetal growth restriction. Preeclampsia complicates pregnancy in all patients with either mild, moderate, or severe COVID-19. The risk of premature birth with a high probability is determined by the moderate and severe courses of the disease. Only moderate COVID-19 during pregnancy is associated with the risk of induced labor. The risk of operative delivery by cesarean section is significantly increased in moderate and severe COVID-19. Moderate and severe courses of the underlying disease during pregnancy determine a high probability of low body weight of children at birth. The risk of hospitalization in the resuscitation unit is associated with moderate and severe COVID-19 during pregnancy.
CONCLUSIONS:Maternal mortality among women with COVID-19 who were hospitalized in an obstetric hospital was 3,636 per 100,000 live births. Perinatal mortality in patients who suffered a new coronavirus infection during pregnancy was 52.6‰.
Experience of surgical treatment of Bartholin duct cysts in outpatient department
Authors: Sudakov Dmitriy S. , Dymarskaya Yulia R.
Published: November 2023

Background. The optimal surgical technique for the treatment of Bartholin duct cysts is still not finally chosen. Currently, the following methods are used: needle aspiration, with or without alcohol sclerotherapy; silver nitrate cyst ablation; use of lasers technique; fistulization using a Word catheter, Foley catheter, or a Jacobi ring; incision and drainage followed by primary suture closure; marsupialization of the cyst; gland excision. However, the frequency of recurrence of the disease is high and averages about 20%. This article presents an original technique of suturing when performing marsupialization of Bartholin duct cysts and an analysis of the results of treatment of patients using this technique.
Aims: to evaluate the results of surgical treatment of Bartholin duct cysts using an original technique for creating a new ostium of the duct during marsupialization.
Materials and methods. 14 patients aged 23 to 39 years with diagnosis of Bartholin duct cysts were operated on during the period from 2018 to 2023. Operations were performed in the outpatient department. Marsupialization was chosen as the method of surgical treatment. The operation was performed using local anesthesia by lidocaine. After emptying, the cyst cavity was washed with an antiseptic. The external ostium of the Bartholin duct was formed by circular suturing of the cyst into the tissues of the vagina vestibule according to the original method.
Results. The maximum size of Bartholin duct cysts in the patients treated by us was up to 5.0 cm and averaged 4.4±0.2 cm. The patients complained on the presence of a unilateral tumor in the entrance to the vagina and moderate intensity pain in its projection. The duration of the operation was from 10 to 15 minutes, the volume of blood loss was from 3.0 to 5.0 ml. There were no complications in the postoperative period. Complete fusion of the tissues of the vestibule of the vagina and the Bartholin duct occurred within a week. The duration of observation of patients after surgical treatment ranged from 5 years to 6 months. There were no relapses of the disease during the observation period.
Conclusions: the results of the study show that the proposed original method of performing marsupialization of the Bartholin duct cysts is an effective and promising technique aimed at preventing recurrence of the disease.
Clinical case of high perinatal risk pregnancy with heterozygous Leiden mutation
Authors: Mochalova Marina N. , Sidorkina Anastasia G. , Akhmetova Elena S. , Khaven Tatyana V. , Kuzmina Lyubov A. , Durova Olga A. , Tomina Elena A. , Solpov Alexey V. , Mudrov Victor A.
Published: November 2023

This article presents the clinical case of hereditary thrombophilia associated with the heterozygous FV (Leiden) mutation. The patient was admitted to the hospital of the 3rd group with diagnosis: «Pregnancy 27 weeks 6 days. Burdened obstetric history. Scar on the uterus. Hereditary thrombophilia associated with a heterozygous mutation of factor V. The state of thrombotic readiness. Hypertension I stage, 1 degree, risk 1, controlled. Alimentary-constitutional obesity of the 1st degree. Endemic diffuse goiter of the 1st degree, euthyroidism. Chronic gastritis, remission.» On admission, the patient received Sol. Enoxaparini natrii at dosage of 0.4 ml subcutaneously 2 times every day, but according to the results of thrombodynamics, thrombotic readiness remained. The purpose of hospitalization was to select anticoagulant therapy. From the anamnesis, it was found that the woman's first pregnancy ended in operative delivery on time due to progressive severe premature detachment of a normally located placenta, intrapartum fetal death. Together with hematologists, the optimal anticoagulant therapy for this patient was selected: Sol. Enoxaparini natrii at dosage of 0.8 ml subcutaneously in the morning, then Sol. Enoxaparini natrii 0.4 ml subcutaneously in the evening, Tab. Acidi acetylsalicylici 0.15. Against the background of this therapy, positive dynamics was noted, normocoagulation was noted during the study of thrombodynamics. After the selection of anticoagulant therapy, the woman was discharged from the hospital under the supervision of an obstetrician-gynecologist of the antenatal clinic and the hematologist of the Clinical Medical Center. Antenatal hospitalization was planned for the period of 37 weeks. The patient was delivered by urgent caesarean section due to prenatal rupture of amniotic fluid at 35 weeks 1 day, given the aggravated anamnesis in patient with the uterine scar. A live premature girl was born weighing 2410 g, 44 cm tall and with an Apgar score of 8 and 8 points. In the postpartum period, given the high risk of thromboembolic complications, the patient was prescribed Enoxaparinum natrium at dosage of 0.4 ml subcutaneously 1 time per day for 6 weeks after delivery. The presented clinical case of pregnancy and childbirth demonstrates the importance of personalization in modern medicine.
The path from a student of a rural school to a known in the country professor of a pediatricist-infectionist
Authors: Ivanov Dmitry O. , Lyakhov Ivan D. , Chernova Tatyana M. , Bannova Svetlana L. , Pavlova Elena B. , Bulina Oksana V. , Sukhovetskaya Vera F. , Barakina Elena V. , Nazarova Anna N. , Kaplina Tatyana A. , Subbotina Maria D. , Pavlova Natalia V. , Fedorova Anna V.
Published: November 2023

In August 2023, Vladimir Nikolaevich Timchenko, dean of the pediatric faculty of the St. Petersburg State Pediatric Medical University of the Russian Ministry of Health, and head of the Department of Infectious Diseases in Children named after Vladimir Nikolaevich, turned 70 years old. Professor M.G. Danilevich, Doctor of Medical Sciences, Professor, Honored Doctor of Russia, Chief freelance specialist in infectious diseases in children of the Northwestern Federal District of the country. V.N. Timchenko after graduating from LPMI with honors in 1978, he entered clinical residency at the Department of Infectious Diseases in Children. Between 1980 and 1983 studied full-time graduate school at the same department. In 1983 he successfully defended his candidate’s dissertation, and in 1989 — his doctoral dissertation. He has headed the department since 1997. Under the leadership of the head of the department, comprehensive studies of infectious diseases in children have been conducted for many years. Vladimir Nikolaevich is the scientific supervisor of ten candidate dissertations, the scientific consultant of one doctoral dissertation. He regularly gives lectures and reports in children’s clinics, at congresses, conferences, and symposiums. Consults seriously ill patients from the Leningrad, Novgorod, Pskov, Kaliningrad Regions, the Republic of Karelia and other regions of the country. Author of more than 530 scientific papers. The administration, public organizations, staff and students of the University wish the professor further great creative success in the training and education of young doctors, good health and personal well-being, inexhaustible energy and prosperity.
Treatment of children with bronchial obstruction syndrome on the background of connective tissue dysplasia: realities and prospects
Authors: Tsymbal Anastasia A. , Arsentiev Vadim G. , Shabalov Nikolai P. , Dumova Natalia B. , Pakhomova Mariya A.
Published: November 2023

BACKGROUND:According to Rosstat, respiratory diseases are the most common reason for children to seek medical help. Anatomical and physiological features of the child’s body and infectious factors predispose to the development of bronchial obstruction syndrome. The scientific literature describes that the presence of connective tissue dysplasia (CTD) worsens the course of bronchial obstruction syndrome. It is important to detect CTD in children with respiratory diseases, as they require more invasive examination methods. This group of patients has specific features of therapy, they need more careful dynamic monitoring.
AIM:Identification of CTD based on phenotypic signs and study of its features in patients of the pediatric pulmonology department with bronchial obstruction syndrome and chronic bronchial inflammation, assessment of the severity of the disease, analysis of examination methods and therapy.
MATERIALS AND METHODS:The article presents data from a one-stage cohort study of 380 patients with bronchoobstructive syndrome who received inpatient treatment in the conditions of the pulmonology department of the St. Petersburg State Medical Institution “K.A. Rauhfus Children’s City Clinical Center of High Medical Technologies”, in the period from 2019 to 2022.
RESULTS:Conventional therapy, which is used to treat bronchial asthma, is not always effective for patients with CTD. Pediatric patients with CTD and bronchial asthma who are being treated in the pulmonology department are subjected to greater radiation exposure and procedures with a higher level of invasiveness, including fibrobronchoscopy.
CONCLUSIONS:Children with CTD are characterized by a burdened anamnesis of bronchopulmonary pathology (complicated course of pneumonia, spontaneous pneumothorax), the absence of complicated heredity by atopy. In the group of children with CTD, the prevalence of severe bronchial asthma and obliterating bronchiolitis was revealed. Examination of patients with CTD requires expensive diagnostic studies (computed tomography of the chest organs, fibrobronchoscopy), in the acute period of the disease — the appointment of systemic glucocorticosteroids, humanized monoclonal anti-IgE drugs are used to treat the disease.
Congenital organic hyperinsulinism. Phenotype spectrum predetermined by  ABCC8  gene variants
Authors: Ivanov Dmitry O. , Ditkovskaya Liliya V. , Maryina Olga I. , Turkunova Mariia E. , Suspitsin Evgeny N. , Prokhorovich Tatyana I.
Published: November 2023

Congenital hyperinsulinism is a hereditary disease belonging to the orphan group, clinically manifested by the development of persistent hypoglycemia in the neonatal period. Neurological disorders resulting from persistent hypoglycemia, in most cases, are accompanied by dysfunction of the central nervous system, regression and delayed psychomotor and speech development. Congenital hyperinsulinism is characterized by heterogeneity of disease phenotypes, manifested by different severity of hypoglycemic syndrome, metabolic and neurological manifestations, which makes it difficult to verify the diagnosis, dictates the need for a comprehensive examination, including molecular genetic analysis in patients and their families. This allows timely appointment of insulinostatic therapy, thereby reducing the risk of severe neurological and metabolic complications. The article presents a description of three clinical cases of сongenital hyperinsulinism associated with homozygous variants in theABCC8gene and an autosomal recessive type of inheritance, which were included in the number of patients previously studied by us with variants in theABCC8andKCNJ11genes. The results of this study were partially published by the authors earlier. The experience of monitoring these patients reflects the importance of early diagnosis of сongenital hyperinsulinism, including the use of molecular genetic testing, the timely administration of insulinostatic therapy, allows an objective assessment of the effectiveness of the treatment, and reduces the risk of developing severe metabolic and neurological complications.