bluuebunny/crossref_metadata_2025 huggingface dataset:
Tay-Sachs Disease: From Molecular Characterization to Ethical Quandaries and the Possibility of Genetic Medicine
Authors: Smith Jessica F. , Henderson Jeffrey O.
Published: December 2022

Tay-Sachs disease (TSD) is a rare neurodegenerative disorder caused by mutations in the HEXA gene, which encodes the ɑ subunit of the enzyme β-hexosaminidase A. Lacking this key enzyme in GM2 ganglioside catabolism, individuals who are homozygous for HEXA mutations suffer from abnormal accumulation of GM2 ganglioside in brain and nerve cells, ultimately resulting in the progressive deterioration of the central nervous system. TSD is one of three disorders characterized by β-hexosaminidase deficiency; Sandhoff disease (SD) and the AB variant arise by mutations in the HEXB and GM2A genes respectively, which disrupt other points of GM2 ganglioside degradation. Characterized by developmental delay and stagnation, muscular weakness, coordination deficits, seizures, and eventual hearing and vision loss, these three disorders are clinically indistinguishable and occur in three forms defined by age of onset. While there is a much higher incidence of TSD in the Ashkenazi Jewish population, community carrier screening and counseling initiatives have reduced disease prevalence to about the equivalent of non-Jewish populations; however, such efforts have raised ethical concerns in the Jewish community that are increasingly relevant in light of scientific and medical advancements. Currently, treatments for TSD and its related disorders focus on symptom management, with gene therapies and the application of modified CRISPR-Cas-9 technology being explored.
Clinical Case of Bilateral Mandibular Auto Transplantation for Missing Bilateral First Molars: Case Report and Review of Literature
Authors: Kasuga Taichi , Yamazaki Samito , Yamazaki Hideo , Shinmyouzu Kouhei
Published: December 2022

Auto transplantation is a fast and economical option when a suitable donor tooth is available for replacement of a tooth considered impossible to treat. The purpose of this case report is to describe methods used for autotransplantation and its advantages for cases with a missing bilateral mandibular firstmolar, as compared with a dental implant, removable partial denture, and other methods of prosthesis. In the present patient who underwent auto transplantation, clinical and radiographic outcomes were considered satisfactory at one and two years postoperatively. Bone healing was observed around the roots of transplanted teeth, which showed good function. In autotransplantation cases, even when the donor tooth has complete root formation, a high success rate can be achieved when the patient is properly selected and treated. Although the chance of root resorption remains because of necrotic pulp and periodontal irritation during manipulation, auto transplantation should be considered as a good treatment modality in feasible cases. Based on the present findings, even though autotransplantation is not common in general dental practice, we consider that it offers a clinically and economically viable alternative as compared to other more complicated prosthetic and dental implant treatments.

The purpose of this report is to show that auto transplantation is a superior treatment method for single molar defects as compared to other prosthetic methods, as the periodontal ligament of the patient can be used and cutting adjacent teeth is avoided. In addition, it is a treatment method that can effectively utilize a wisdom tooth.
A One-Pot Synthesis of Sulfonyl Amidinesvia Three-Component Reaction Under Mild and Solvent-Free Conditions
Authors: Adiche Chiaa , El Abed Douniazad
Published: December 2022

A convenient one-pot synthetic protocol for the preparation of sulfonyl amidines has been developed. The procedure combines three-component reaction of sulfonyl azide, methyl propiolate and secondary cyclic amine coupling in one sequence without any solvent or catalyst and at room temperature. The reaction proceeds smoothly and a variety of desired sulfonyl amidines were obtained in moderate to good yields. This protocol has synthetic advantages in terms of low environmental impact and very short reaction time.
Can Alveolar-Arterial Oxygen Pressure Difference be used to Diagnose Acute Respiratory Distress Syndrome in Pneumonia Patients?
Authors: Wang Ling , Wang Wanling
Published: December 2022

Alveolar-arterial oxygen pressure difference (P(Aa)O2) can reflect pulmonary ability to exchange oxygen; it shows good correlation with the oxygenation index (OI), which is important in diagnosing acute respiratory distress syndrome (ARDS). This study explored the ability of P(Aa)O2 in diagnosing ARDS in pneumonia patients.

Methods
We selected patients with community-acquired pneumonia and sepsis in the intensive care unit (ICU) of the People’s Hospital of Qiandongnan Miao and Dong Autonomous Prefecture; we measured P(Aa)O2 and the OI under anoxic conditions upon their admittance to the ICU. We divided the patients into ARDS and non-ARDS groups. We compared the differences in P(Aa)O2 and OI; we analyzed the correlation between P(Aa)O2 and ARDS. To assess the diagnostic ability of P(Aa)O2 for ARDS, we drew the receiver operating characteristic (ROC) curve.

Result
We found that P(Aa)O2 in the ARDS group was greater than in the non-ARDS group (t = 8.875, P <0.001); the OI in the ARDS group was smaller than in the non-ARDS group (t = –6.956, P <0.001). There was a positive correlation between P(Aa)O2 and ARDS (r = 0.718, P <0.001). The area under the ROC curve for P(Aa)O2 in the diagnosis of ARDS was 0.931 (0.873–0.988); the cutoff value was 214.70 mmHg, the sensitivity was 89.50%, and the specificity was 85.00%.

Conclusion
We conclude that P(Aa)O2 is a good reference index in diagnosing ARDS
The White Power of White Space: Rhetorical Collusion and Discriminatory Design in the Obama-Trump Inauguration Photo
Authors: Pierce Lee M.
Published: December 2022

When side-by-side photographs of the 2009 and 2017 U.S. presidential inauguration crowds circulated after President Trump's inauguration, few doubted what they saw: the crowd in 2017 was significantly smaller than it had been eight years earlier. Whereas popular discourse around the photo obsessed over size of the crowds, I argue that differences in contrast, color, and clarity suggest a different narrative than the logic of quantity: Trump will return an orderly, white national body, cleansed of Obama's unruly, sepia swarm. This essay re-reads a key moment of recent U.S. visual politics, turning what came to be read as either a joke or a preview of the “death of facts” as something more sinister: a visual harbinger of Trump's white supremacist program.
The Rhetoric of Narcissism: Trump's Tweets on Writing
Authors: Berg William J.
Published: December 2022

Donald Trump's tweets on writing, whether his own or the print media's, typically employ an extreme form of rhetoric involving the manipulation of meaning and construction of self-serving arguments. The practice of close reading suggests that these tweets often display several types of rhetorical operation, which distort the message through the amalgamation, expansion, contraction, and reversal of meaning to create expressions like “the Fake News.” These polysemous expressions are then combined to form word groups, all centered on the self but each designed to meet a particular narcissistic need, from self-promotion and self-proclaimed victory to self-defense and self-casting as the Messiah. Trump's tweets often take the form of a triangular configuration, composed of the writer to proclaim, an adversary to be conquered, and a witness to validate the victory. By putting at least two of the three actors into play within its reduced space, the tweet becomes a miniature psychodrama—scripted, cast, and staged by the narcissist for an audience of kindred spirit.
Literatura infantil y videorreseñas
Authors: Segovia Gordillo Ana , Herranz-Llácer Cristina V.
Published: December 2022

Este artículo vincula herramientas digitales, inclusión y literatura aprovechando el fenómeno booktuber. Con este marco, los futuros maestros de infantil grabaron una videorreseña recomendando un relato con la inclusión o diversidad como tema central. Así, se reseñaron títulos relacionados con la discriminación física o intelectual, los trastornos de aprendizaje, la identidad, etc. Los datos muestran que los participantes incrementaron su compromiso con la inclusión y descubrieron historias nuevas. Como conclusión, se afirma que la introducción de videorreseñas ha repercutido positivamente en los estudiantes. En concreto, han mejorado su conocimiento sobre la inclusión/diversidad y han desarrollado y perfeccionado sus competencias literaria y lingüística.
Minimally Invasive Beating Heart Mitral Valve Repair in a Patient With Connective Tissue Disease at Prohibitive Risk for Redo Sternotomy
Authors: Hassanabad Ali Fatehi , Svystonyuk Daniyil A. , Kent William D. T.
Published: December 2022

Sternal reentry when the ascending aorta is adherent to the posterior table of the sternum is associated with substantial risk. A minimally invasive right thoracotomy beating heart approach is an alternative when the aorta cannot be cross-clamped. This report details this technique for a complex reoperative mitral valve repair procedure performed in a patient with connective tissue disease who had required multiple aortic operations and presented with heart failure and severe functional mitral regurgitation.
ORPHEU E PRESENÇA NO DESENROLAR DO MODERNISMO PORTUGUÊS
Authors: Rodrigues João , Veiga Ana Beatriz Machado Alves Ramos , Costa Bruna Filipa Esteves da , Monteiro Maria Francisca Aguiar
Published: December 2022

Num contexto em que os ideais da época sofriam transformações, dá-se a rutura com o passado e desponta o movimento Modernista. É neste período de conturbação que irrompem as revistas “Orpheu” e “Presença”. Vinculados a estas revistas surgem nomes como Sá Carneiro, Almada Negreiros e Fernando Pessoa, que perpetuam esta mudança. O Modernismo vem edificar a mudança a nível da arte e da literatura, onde é privilegiada a imaginação do artista: o modernismo tende a representar-se como um movimento marcado pela sua rutura em relação às expressões artísticas do passado. Pelo facto deste movimento se ter prolongado na segunda república e atravessado o Estado Novo, a liberdade de expressão foi necessariamente condicionada, de acordo com os pressupostos ideológicos do regime. Perante este clima de subjugação e de repressão Cultural, surgiram neste período importantes figuras pertencentes às gerações anteriores que, mais tarde, deram voz aos movimentos intelectuais e que foram a base do progresso do Modernismo Português. Estes movimentos intelectuais reacionários foram de organização privada, onde através do lançamento de revistas foram introduzidas inovações no país. Todavia, este pensamento não teve o alcance esperado, em parte, consequência de um baixo nível de alfabetização de um País rural e conservador.
EMERGENCY LAW IN THE INDONESIAN LEGAL SYSTEM
Authors: Ekowati Debby
Published: December 2022

This study seeks to determine and examine the position of Emergency Law within the context of Legal Studies and the presence of Emergency Law within the Indonesian Legal System. This study employs a normative legal methodology. The normative legal research approach investigates the law internally, with legal norms as the study object. Government Regulation in Lieu of Law is required if a country is confronted with an urgent and compelling situation that necessitates swift action. For this reason, while issuing Government Regulations in Lieu of Laws, the President implements them by the Constitution, legislative oversight, and, of course, the oversight of the people as sovereigns. The outcomes demonstrated.
Culture and emotion in Paralympic swimming medalists
Authors: Martin Jeffrey J. , Snapp Erin , Loetzner Franziska , Dehghan Fatemeh , Prokešová Eva , Bastos Tania
Published: December 2022

The purpose of the present study was to examine if cultural identity was related to the emotional experiences of Paralympic (N = 83) swimmers’ upon winning medals at the 2016 Paralympic Games. Paralympic athletes’ countries (N = 5) were scored on Hofstede’s (2011) six cultural dimensions and athletes who won medals had their facial expressions analyzed to determine levels of basic emotions (i.e., happiness, sadness, anger, surprise, disgust, fear, and neutral) based on Ekman’s (1993) neuro-cultural theory of emotion. After controlling for medal won, and time and place expectation proxies, we found that happiness was negatively associated with long/short term orientation (r = –0.313, p < 0.004) and positively linked to indulgence/restraint (r = 0.210, p < 0.06). The emotion of neutral was positively associated with power distance (r = 0.239, p < 0.032) and long term/short term orientation (r = 0.290, p < 0.009) while being negatively linked to indulgence (r = –0.276, p < 0.013). Based on an abductive theory of the scientific method (Haig, 2005; 2008) we formed plausible theory-based explanations for our findings and concluded, given our study is the first of its nature, that researchers should continue this line of inquiry.
Impact of diagnostic checklists on the interpretation of normal and abnormal electrocardiograms
Authors: Staal Justine , Zegers Robert , Caljouw-Vos Jeanette , Mamede Sílvia , Zwaan Laura
Published: December 2022

Objectives

Checklists that aim to support clinicians’ diagnostic reasoning processes are often recommended to prevent diagnostic errors. Evidence on checklist effectiveness is mixed and seems to depend on checklist type, case difficulty, and participants’ expertise. Existing studies primarily use abnormal cases, leaving it unclear how the diagnosis of normal cases is affected by checklist use. We investigated how content-specific and debiasing checklists impacted performance for normal and abnormal cases in electrocardiogram (ECG) diagnosis.

Methods

In this randomized experiment, 42 first year general practice residents interpreted normal, simple abnormal, and complex abnormal ECGs without a checklist. One week later, they were randomly assigned to diagnose the ECGs again with either a debiasing or content-specific checklist. We measured residents’ diagnostic accuracy, confidence, patient management, and time taken to diagnose. Additionally, confidence-accuracy calibration was assessed.

Results

Accuracy, confidence, and patient management were not significantly affected by checklist use. Time to diagnose decreased with a checklist (M=147s (77)) compared to without a checklist (M=189s (80), Z=−3.10, p=0.002). Additionally, residents’ calibration improved when using a checklist (phase 1: R2=0.14, phase 2: R2=0.40).

Conclusions

In both normal and abnormal cases, checklist use improved confidence-accuracy calibration, though accuracy and confidence were not significantly affected. Time to diagnose was reduced. Future research should evaluate this effect in more experienced GPs. Checklists appear promising for reducing overconfidence without negatively impacting normal or simple ECGs. Reducing overconfidence has the potential to improve diagnostic performance in the long term.
Key point extraction method for spatial objects in high-resolution remote sensing images based on multi-hot cross-entropy loss
Authors: Chen Jun , Yu Zhengyang , Yang Cunjian
Published: December 2022

Extracting spatial objects and their key points from remote sensing images has attracted great attention of worldwide researchers in intelligent machine perception of the Earth’s surface. However, the key points of spatial objects (KPSOs) extracted by the conventional mask region-convolution neural network model are difficult to be sorted reasonably, which is a key obstacle to enhance the ability of machine intelligent perception of spatial objects. The widely distributed artificial structures with stable morphological and spectral characteristics, such as sports fields, cross-river bridges, and urban intersections, are selected to study how to extract their key points with a multihot cross-entropy loss function. First, the location point in KPSOs is selected as one category individually to distinguish morphological feature points. Then, the two categories of key points are arranged in order while maintaining internal disorder, and the mapping relationship between KPSOs and the prediction heat map is improved to one category rather than a single key point. Therefore, the predicted heat map of each category can predict all the corresponding key points at one time. The experimental results demonstrate that the prediction accuracy of KPSOs extracted by the new method is 80.6%, taking part area of Huai’an City for example. It is reasonable to believe that this method will greatly promote the development of intelligent machine perception of the Earth’s surface.
Comparison of hospitalized patients with severe pneumonia caused by COVID-19 and influenza A (H7N9 and H1N1): A retrospective study from a designated hospital
Authors: Gu Binbin , Yao Lin , Zhu Xinyun , Tang Peijun , Chen Cheng
Published: December 2022

Considerable attention has been focused on the clinical features of coronavirus disease 2019 (COVID-19), but it is also important for clinicians to differentiate it from influenza virus infections. In the present study, the rate of coexisting disease was lower in the severe COVID-19 group than in the influenza A group (p = 0.003). Radiologically, severe COVID-19 patients had fewer instances of pleural effusion (p < 0.001). Clinically, severe COVID-19 patients had relatively better disease severity scores, less secondary bacterial infections, shorter times to beginning absorption on computed tomography, but longer durations of viral shedding from the time of admission (p < 0.05). Although the more severe influenza A patients required noninvasive respiratory support, these two groups ultimately yielded comparable mortalities. Based on the multiple logistic regression analysis, severe COVID-19 infection was associated with a lower risk of severe acute respiratory distress syndrome [odds ratio (OR) 1.016, 95% [confidence interval (CI)] 1.001–1.032, p = 0.041] and a better pneumonia severity index (OR 0.945, 95% [CI] 0.905−0.986, p = 0.009); however, these patients exhibited longer durations of viral shedding (OR 1.192, 95% [CI] 1.047−1.357, p = 0.008) than patients with severe influenza A infection. In conclusion, the conditions of severe influenza A patients appeared to be more critical than that of severe COVID-19 patients. However, relatively lower mortalities of these two severe cases are expected in the context of sufficient medical supplies.
Local existence and blowing up phenomena for a class of non-autonomous partial functional differential equations with infinite delay
Authors: Diop Mamadou Abdoul , Ezzinbi Khalil , Kyelem Bila Adolphe
Published: December 2022

In this work, we study a class of abstract non-autonomous partial functional differential equations with infinite delay. Our main results concern the local existence of the mild solution which can blow up at the finite time. The unbounded operators associated to the non-autonomous system are assumed to be stable family which generates C
0-semigroups while the nonlinear part is supposed to be continuous. Under Lipschitz condition on the nonlinear term of the equation, we prove the existence and uniqueness of the mild solution. For illustration, we provide an example for some reaction-diffusion non-autonomous partial functional differential equations involving infinite delay.
Experimental investigation into paper dust formation during knife edge cutting on a laboratory scale
Authors: Lunewski Johannes , Schmidt Eberhard
Published: December 2022

Especially in the field of paper and print post-processing on an industrial scale, continuous cutting operations generate paper dust. Despite preventive measures like dedusting units, a high paper web velocity induces the release of particulate dust. As a result, the particles settle and accumulate on machine components and in the surrounding area. Resuspended particles around a potential ignition source represent a fire hazard. The prevention of such fire incidents requires frequent servicing and maintenance. However, the shutdown time on industrial scale applications remains cost-intensive.

In this research, a cutting plotter executes reproducible knife edge cutting sequences to identify significant parameters affecting the paper dust formation on a macro and micro scale. For this purpose, an extraction system collects the exposed particles along the cutting line. The applied methods include gravimetric determination of the dust mass and dynamic image analysis to characterise particle size and shape. Final results indicate a significant influence of the blade wear condition.
Intrinsic Excitability in Layer IV–VI Anterior Insula to Basolateral Amygdala Projection Neurons Correlates with the Confidence of Taste Valence Encoding
Authors: Kolatt Chandran Sailendrakumar , Yiannakas Adonis , Kayyal Haneen , Salalha Randa , Cruciani Federica , Mizrahi Liron , Khamaisy Mohammad , Stern Shani , Rosenblum Kobi
Published: December 2022

Avoiding potentially harmful, and consuming safe food is crucial for the survival of living organisms. However, the perceived valence of sensory information can change following conflicting experiences. Pleasurability and aversiveness are two crucial parameters defining the perceived valence of a taste and can be impacted by novelty. Importantly, the ability of a given taste to serve as the conditioned stimulus (CS) in conditioned taste aversion (CTA) is dependent on its valence. Activity in anterior insula (aIC) Layer IV–VI pyramidal neurons projecting to the basolateral amygdala (BLA) is correlated with and necessary for CTA learning and retrieval, as well as the expression of neophobia toward novel tastants, but not learning taste familiarity. Yet, the cellular mechanisms underlying the updating of taste valence representation in this specific pathway are poorly understood. Here, using retrograde viral tracing and whole-cell patch-clamp electrophysiology in trained mice, we demonstrate that the intrinsic properties of deep-lying Layer IV–VI, but not superficial Layer I–III aIC-BLA neurons, are differentially modulated by both novelty and valence, reflecting the subjective predictability of taste valence arising from prior experience. These correlative changes in the profile of intrinsic properties of LIV–VI aIC-BLA neurons were detectable following both simple taste experiences, as well as following memory retrieval, extinction learning, and reinstatement.
New perspectives on fertility in transwomen with regard to spermatogonial stem cells
Authors: Dabel Jennifer , Schneider Florian , Wistuba Joachim , Kliesch Sabine , Schlatt Stefan , Neuhaus Nina
Published: December 2022

Objective

Germ cells of transwomen are affected by gender-affirming hormone therapy (GAHT). Fertility will be lost after surgical intervention; thereby, fertility preservation becomes an increasingly imortant topic. This study investigated if the absolute number of spermatogonia in transwomen is comparable at the time of gender-affirming surgery (GAS) to that in pre-pubertal boys.

Methods

We carried out a retrospective study of testicular tissues from 25 selected subjects, which had undergone a comparable sex hormone therapy regimen using cyproterone acetate (10 or 12.5 mg) and estrogens. As controls, testicular biopsies of five cisgender adult men (aged 35–48 years) and five pre-/pubertal boys (5–14 years) were included. Testicular tissues were immunohistochemically stained for MAGE A4-positive cells, the most advanced germ cell type. The number of spermatogonia per area was assessed. Clinical values and serum hormone values for FSH, LH, testosterone, free testosterone, estradiol and prolactin were determined on the day of GAS for correlation analyses.

Results

Round spermatids were the most advanced germ cell type in 3 subjects, 5 had an arrest at spermatocyte stage, while 17 showed a spermatogonial arrest. On average, testicular tissues of transwomen contained 25.15 spermatogonia/mm3, a number that was significantly reduced compared to the two control groups (P < 0.01, adult 80.65 spermatogonia/mm3 and pre-/pubertal boys 78.55
spermatogonia/mm3). Linear regression analysis revealed that testes with higher weight and high LH contained more spermatogonia.

Conclusion

Irrespective of treatment dose or duration, spermatogenesis was impaired. Spermatogonial numbers were significantly reduced in transwomen compared to the control groups.

Lay summary

When transwomen go through treatment to confirm their gender, their germ cells are affected. They lose their fertility after surgery, so fertility preservation becomes an important topic. We carried out a study looking at tissue from testes of 25 people who had been through the same sex hormone therapy until surgery. Blood samples were also taken. As controls, samples were taken from the testes of cisgender boys and adult men. On average, the samples from the testes of transwomen contained a smaller number of early sperm cells compared to the two control groups. Regardless of the dose or length of hormone treatment, the fertility of transwomen was significantly reduced so that counseling about fertility preservation should be offered before hormone therapy.
"In Memoriam" José Ramón Alberte Castiñeiras (1945-2022)
Authors: Pernas Morado Eulogio
Published: December 2022

In Memoriam José Ramón Alberte Castiñeiras
Reseña del libro: Enseñanza de las ciencias sociales. Pensar, sentir, hacer, de Paulina Latapí Escalante
Authors: Valencia Castañeda Lucía
Published: December 2022

Teaching of social sciences. Thinking, Feeling, Doing (2021), is a book that from its suggestive title leads us to the essence of the act of teaching. In just over three hundred pages, Paulina Latapí Escalante takes a tour of her experiences and reflections as a researcher and as a trainer of future and practicing social science teachers.
Los principales atributos de un profesor de calidad: las representaciones sociales de los estudiantes y egresados del Liceo Colonia Puntarenas, Costa Rica
Authors: Orias Sarmiento Esteban
Published: December 2022

This article explores the social representations of the students of the Liceo Colonia Puntarenas (cantón de Upala), as well as the perceptions of the students who graduated from this same institution. The second group is studying the first or second year of career, both in public and private universities. It is interesting to interpret the social representations about what they understand by a quality teacher. The goal is to provide inputs to create an educator profile that is closer to the vision of the students. Future inquiries will delve into aspects related, specifically, to the area of Social Studies. This analytical exercise is considered an exploratory first stage. This work is part of the project for the improvement of educational quality of the Ministry of Public Education called MECEC, however, it examines the changes and continuities that occur between the last level of secondary school and the first level of the university.
“Ética, Estética y Ciudadanía”, un abordaje desde la memorización
Authors: Álvarez Rivera Josseth , Chaves Valverde Martha Stephanie , Rodríguez Vargas María José
Published: December 2022

This article identifies the conceptual approach of citizenship and citizen participation present in the Citizenship Education’s curriculum of Costa Rican secondary education. To achieve this goal, it has been developed a document analysis. The process started with a general reading of the document, to establish the presence or absence of the analysis units, these allows the comprehension of the theory farther than the democratic institutional perspective. Later, it was identified the frequency of the concepts, stablished by two dimensions a theorical and a practical dimensions. This comparative process showed a memorization trend, related to citizenship and citizen participation, in the expected learning of the school curriculum.
СОЦІАЛЬНИЙ КАПІТАЛ У РОЗВИТКУ СИСТЕМИ НАЦІОНАЛЬНОЇ ЕКОНОМІКИ
Authors: Грицаєнко М. , Грицаєнко Г. , Коломієць В. , Фесенко М.
Published: December 2022

Вступ. Соціальний капітал через громадську довіру, посилення солідарності та відчуття приналежності може сприяти підвищенню ефективності участі населення у програмах розвитку національної економіки.
Проблематика. Дослідження означеного питання набуває особливої актуальності внаслідок пошуку додаткових можливостей в реалізації інституційних перетворень, розвитку інвестиційної, інноваційної та підприємницької діяльності.Мета. Дослідження соціального капіталу як важливого чинника розвитку системи національної економіки.Матеріали й методи. Застосовано методи порівняльного аналізу, монографічний, абстрактно-логічний. Інформаційною базою дослідження є дані Світового банку, Європейської Бізнес Асоціації, Державної служби статистики України, Інституту соціології НАН України.Результати. Визначено сутність понять «розвиток», «система», «національна економіка» та «соціальний капітал». Розглянуто структуру національної економіки в інституційному, соціально-економічному, просторовому, галузевому, відтворювальному, технологічному та зовнішньоекономічному розрізах. Запропоновано та проаналізовано в динаміці індикатори стану та розвитку системи національної економіки та соціального капіталу, виявлено взаємозв’язок між ними. Встановлено наявність зв’язку між рівнем довіри в суспільстві та розвитком соціальних мереж. Виявлено вплив соціального капіталу на саморегулювання підприємницької діяльності, внесено пропозиції щодо його ефективного формування та використання в національній економіці.Висновки. Соціальний капітал виступає драйвером інституційних перетворень, засобом горизонтального й вертикального зв’язку між елементами національної економіки. Доведено його вплив на процвітання країни, а також зв’язок з індикаторами інвестиційної, інноваційної та підприємницької діяльності. Суб’єкти національної економіки за рахунок соціального капіталу мають додаткові конкурентні переваги через спільне використання власних ресурсів і зниження трансакційних витрат.
Нові методи оцінювання міцності та прогнозування ресурсу критичних елементів обладнання АЕС
Authors: Чирков Олександр Юрійович
Published: December 2022

Доповідь присвячено результатам досліджень, проведених в Інституті проблем міцності ім. Г.С. Писаренка НАН України щодо створення уточнених моделей і методів розв’язання актуальних прикладних задач механіки, пов’язаних з обґрунтуванням міцності та прогнозуванням ресурсу елементів обладнання реакторних установок АЕС з водо-водяним енергетичним реактором (ВВЕР).
Хемоінформатика як ефективний інструмент прогнозування і конструювання нових речовин з комплексом необхідних властивостей
Authors: Кузьмін Віктор Євгенович
Published: December 2022

Доповідь присвячено результатам фундаментальних та прикладних наукових досліджень у галузі хемоінформатики, проведених у Фізико-хімічному інституті ім. О.В. Богатського НАН України і пов’язаних з аналізом зв’язків «структура — властивості» хімічних речовин з метою цілеспрямованого створення нових сполук і матеріалів з комплексом заданих властивостей.
Аналіз результатів оцінювання ефективності діяльності наукових установ НАН України в першому раунді оцінювання за період 2016—2022 рр.
Authors: Єгоров Ігор Юрійович , Жукович Інна Анатоліївна , Ступіна Лада Володимирівна , Артюшенко Віктор Вікторович
Published: December 2022

У статті підбито підсумки першого раунду оцінювання ефективності діяльності наукових установ НАН України та їхніх підрозділів за період 2016—2022 рр. Проведено порівняння результатів оцінювання наукових установ за Методикою НАН України та їх державної атестації за Методикою МОН України. Окреслено шляхи подальшого вдосконалення процедури та методики оцінювання.
Variabilidad morfológica/patogénica de Fusarium verticillioides en la Ciénega/Chapala, México y evaluación de técnicas de inoculación
Authors: Zácamo-Velázquez Norma Y. , Ireta-Moreno Javier , Salinas-Moreno Yolanda , Gómez-Rodríguez Víctor M. , Ramírez-Vega Humberto , Martínez-Loperena Raquel
Published: December 2022

Introducción. La pudrición de mazorca en maíz causada por Fusarium verticillioides es una enfermedad de las más importantes en el mundo. En México ocasiona pérdidas de hasta 30 %. El incremento en los niveles de esta enfermedad en los últimos años requiere inspecciones en las zonas productoras para identificar las principales cepas que afectan el grano de maíz. Objetivo. Determinar la variabilidad morfológica y patogénica de aislados de F. verticillioides de muestras de maíz de la zona productora de maíz La Ciénega/Chapala, México, e identificar la mejor técnica de inoculación del patógeno en mazorcas. Materiales y métodos. Se obtuvieron veinte aislamientos de F. verticillioides de muestras de granos de maíz con síntomas de la enfermedad. Los aislamientos se usaron para inocular, mediante diferentes técnicas, mazorcas en desarrollo (R2) del maíz P-3057 cultivado en Tepatitlán, Jalisco en el ciclo Primavera/Verano 2019 bajo condiciones de temporal. Se evaluó la incidencia y severidad de la infección (SDI) de los aislamientos y la morfología microscópica de las cepas. Resultados. Los aislamientos de F. verticillioides difirieron en color de la colonia, tipo de micelio, abundancia y coloración del micelio vegetativo. La incidencia y severidad fueron estadísticamente diferentes entre los aislamientos de F. verticillioides y las técnicas de inoculación probadas, con interacción entre aislamientos y técnicas de inoculación. La incidencia de la enfermedad mostró valores de 82 y 95 % con las técnicas de inoculación por aspersión y del palillo, respectivamente. La SDI varió entre 8 % y 15,5 % con las técnicas de inoculación por aspersión y palillo, en ese orden. Conclusiones. Las cepas de F. verticillioides mostraron variabilidad para patogenicidad y severidad de la infección. La patogenicidad se relacionó con la técnica de inoculación utilizada. La técnica de inoculación del palillo fue la que presentó mayor incidencia y severidad de la infección.
The relationship between Consumer Confidence Index and BIST 50 Index
Authors: Huseynli Nigar
Published: December 2022

Decisions made by consumers depending on psychological factors affect the incomes of companies and, accordingly, the financial markets. In this study, the causality relationship between consumer confidence index, BIST 50 index and BIST electricity is discussed. In this study, which was conducted with the assumption that there may be a causal relationship between the consumer confidence index and BIST 50 and BIST electricity indices, the causality relationship between the consumer confidence index, BIST 50 index and BIST electricity index was examined with the Granger causality test covering the periods 2012:01-2022:06. As a result of the tests carried out considering the lag lengths, a one-way causality relationship was determined between the BIST 50 index and the BIST electricity index.
The Hungarian sword of constitutional identity
Authors: Várnay Ernő
Published: December 2022

In its ‘refugee quota decision’ of 2016 the Hungarian Constitutional Court (HCC) ‘invented’ its competences of ultra vires, sovereignty and constitutional identity controls. The sword of constitutional identity (CI) has been forged against foreign – first of all – EU law. In the development of the new concept the interplay between the Government, the Government-dominated parliament and the Constitutional Court loyal to the Government seems to be evident. The textual analysis of the relevant HCC's decisions proves that the Hungarian Constitutional identity (HCI) contains legal acts in force – including the Fundamental Law (constitution) and the Founding treaties of the EU -, legal acts ‘not in force but valid’ and activities related to the fight for independence of the Hungarian State.

As far as the nature of the HCI is concerned, the article demonstrates the strong relationship with sovereignty control, and the ‘historical constitution’ and emphasises the HCC's statement according to which the CI is not created by the constitution, it is merely acknowledges it.

Given the large number of elements identified as part of the HCI, its openness to the inclusion of further elements, and the questionable nature of the HCI, the author submits that the concept is inappropriate for any meaningful constitutional review.

The HCC – at least until now – despite being invited to do so, has refused to use the sword against EU secondary law and the judgment of the European Court of Justice, and avoided overt constitutional conflict. However, this does not mean that the HCC is ready to enter into sincere dialogue with the court in Luxembourg.
Ernő Dohnányi: A Discography of the Performer
Authors: Szabó Ferenc János
Published: December 2022

The performances of Ernő Dohnányi as pianist and conductor were preserved on numerous sound recordings. He was involved in the recording industry first in 1905, and his death was notoriously caused by a cold suffered in a recording studio in 1960. His interpretation is preserved on different audio media: piano rolls, 78rpm and Long Play discs, x-ray foils and reel-to-reel tapes. Although the number of his studio recordings, made for commercial purposes, is relatively small, the amount of live concert and home recordings, including the huge collection of unpublished recordings made in the USA between 1945 and 1960, expands it to a significant corpus of sound recordings. This article contains the complete discography of Ernő Dohnányi as a performer. The discography provides all available data of the studio and live recordings of Dohnányi, including the data of reissues (closing date: June 2022). It is preceded by an article in which Dohnányi's discography is analysed from several aspects. The analysis of the recorded repertoire sets the stage for further research on Dohnányi's interpretation; however, lost recordings are also reviewed. Dohnányi's controversial relationship to the technical media, and vice versa the recording firms changing interest in him as a performer, are also discussed in detail, involving several sources formerly unknown to Dohnányi research.
SOSIALISASI PROGRAM STICOM DAN PRAKTIK BUDIKDAMBER DI KAMPUNG MAKBUSUM, DISTRIK MAYAMUK, KABUPATEN SORONG
Authors: Ernawati Ernawati , Poltak Hendra , Ruzuqi Rezza , Abadi Agung Setia , Puspitasari Asthervina Widyastami , Hismayasari Intanurfemi Bacandra , Kadarusman Kadarusman , Ziliwu Boby W , Prakoso Bagas
Published: December 2022

STICOM (Smart Tilapia Community)  merupakan program yang digagas oleh prodi. Teknik Budidaya Perikanan Politeknik Kelautan dan Perikanan Sorong dengan bekerjasama dengan pihak Balai Benih Ikan Majaran. Kegiatan tersebut diharapkan meningkatkan kesadaran masyarakat tentang pemanfaatan lahan atau area sempit untuk berbudidaya ikan sekaligus sayur yang efektif dalam ember. Hal tersebut nantinya diharap juga dapat menambah penghasilan warga distrik mayamuk. Kegiatan dilaksanakan menggunakan metode sosialisasi STICOM dan praktik pembuatan BUDIKDAMBER (budidaya ikan dalam ember). Kegiatan sosialisasi mengundang warga distrik mayamuk. Setelah kegiatan tersebut dilakukan, selanjutnya dilakukan survey kepuasan terhadap kegiatan tersebut. Hasil yang didapatkan yakni masyarakat mayamuk merasa puas terhadap kegiatan yang telah dilakukan oleh tim dan berharap kegiatan tersebut dilakukan ulang guna dilakukan evaluasi kegiatan.
Peningkatan Kesadaran Masyarakat Melalui Sosialisasi Peran dan Manfaat Hutan Mangrove
Authors: Hismayasari Intanurfemi , Poltak Hendra , Ismail Ismail , Ernawati Ernawati , Abadi Agung Setia , Puspitasari Asthervina Widyastami , Kadarusman Kadarusman , Ulat Muhamad Ali , Hafita Yuniar Ayu , Moejiono Moejiono , Sutanto Heri , Iskandar Iskandar , Sanusi Syafril , Idris Muhammad , Nalle Charles , Permana I Komang H
Published: December 2022

Kegiatan ini bertujuan untuk mengetahui dampak sosialisasi dalam peningkatan pengetahuan dan pemahaman peran dan manfaat mangrove. Kegiatan sosialisasi diikuti oleh 10 orang peserta menggunakan metode ceramah dan metode praktik lapang. Berdasarkan hasil evaluasi diketahui terjadi peningkatan pengetahuan dan pemahaman peserta terkait peran dan manfaat mangrove dari rata-rata 32% menjadi 95% dan dapat memberikan justifikasi yang tepat sehingga diharapkan peningkatan pengetahuan diiringi dengan peningkatan kesadaran masyarakat untuk turut berpartisipasi aktif dalam menjaga kelestarian hutan mangrove.
role of coral reefs for marine life is as a place to find food, nursery areas, spawning grounds, and as hiding places
Authors: Katili Vicky Rizky , Tjarles Lay , Ulat Muhamad Ali , Kadarusman Kadarusman , Suruwaky Amir M , Hasan Fataha Ilyas , Jusman Jusman , Efendi Lukman , Ismai Ismail
Published: December 2022

The role of coral reefs for marine life is as a place to find food, nursery areas, spawning grounds, and as hiding places. Gag Island is one of the areas that has the potential for the main coral species Acropora sp, but with the increase in pollution from waste that causes sedimentation, and local community activities in fishing activities in ways that are not environmentally friendly, such as the use of bombs that make coral reefs in the area. many of these areas are degraded or damaged. To overcome the sustainability of fishing that is not environmentally friendly, it is the initiative to carry out socialization and transplantation.
Shop Drawing Workshop for cadets of Fisheries Mechanization Study Program Sorong Polytechnic of Marine and Fisheries Using Autocad
Authors: Nurita Purnawanti Yani , Huda Nurul , Nurfauzi Akhmad , Prasetyo Djoko , Sirait Egbert Joshua
Published: December 2022

The lack of competence of Sorong Marine and Fisheries Polytechnic cadets in the field of drawing techniques is one of the causes of the low absorption of graduates in the field of engineering, where the Fisheries Mechanization study program has a curriculum syllabus that is suitable for various engineering industries such as shipbuilding, food processing machinery, ship machinery factories, fishing gear factory, pump factory. While the technical drawing courses taught in the fishery mechanization study program are still limited to manual drawings with paper, as well as tasks in other courses in the form of drawings are also still carried out by manual drawing processes, while technical drawings in industry require accuracy and speed which are difficult to rely on. manual drawing techniques. AutoCad software is one of the computer applications that is considered very effective as a tool in learning and improving students' understanding of technical drawing. Activation of the legal licensed AutoCAD software is expensive, so in this Community Service activity, the AutoCad free Student License activation is carried out, in addition to providing an increase in the soft skills of cadets. The stages of activities in this PKM are: computer inventory in the KP Sorong Polytechnic Computer laboratory, registering the official Autocad student version license for computers in the KP Sorong Polytechnic Computer laboratory, installation & activation of Autocad software on computers in the KP Sorong Polytechnic Computer laboratory, Autocad training for cadets Fisheries Mechanization Study Program KP Sorong Polytechnic, and evaluation of Autocad training for cadets of the Fisheries Mechanization Study Program at KP Sorong Polytechnic. The results achieved are the activation of the AutoCad software with a student license on 34 computers in the computer and telematics lab of the KP Sorong Polytechnic, as well as the improvement in the soft skills of cadets in making shop drawings that can be measured through evaluation, namely as many as 13 cadets passed the training with 8 cadets getting value over 75.
Supplemental materials for book chapter: Microplastics in Marine Food Webs
Authors: Pitt Jordan A. , Aluru Neelakanteswar , Hahn Hahn
Published: December 2022

The identification of microplastics (MPs; 1 µm - 5 mm) and the inferred presence of nanoplastics (NPs; <1 µm) in a wide variety of marine animals, including many seafood species, has raised important questions about the presence, movement, and impacts of these particles in marine food webs. Understanding microplastic dynamics in marine food webs requires elucidation of the processes involved, including bioaccumulation, trophic transfer, and biomagnification. However, in the context of microplastics and nanoplastics these concepts are often misunderstood. In this chapter, we provide a critical review of the literature on the behavior of plastic particles in marine food webs. We find clear evidence of trophic transfer, equivocal evidence for bioaccumulation, and no evidence for biomagnification. We also identify a number of knowledge gaps that limit our ability to draw firm conclusions at this time. These supplemental documents are in support of an invited chapter to be published in this book: S.E. Shumway and J.E. Ward (Eds.) Plastics in the Sea: Occurrence and Impacts (Elsevier 2023).
Effectiveness of neoton in patients with chronic heart failure depending on the left ventricular ejection fraction. Sub-analysis of the BYHEART study
Authors: Tereshchenko S. N. , Cheremisina I. A. , Safiullina A. A.
Published: December 2022

Aim. To study the effectiveness of exogenous phosphocreatine (EPCr) therapy in patients with heart failure (HF) with reduced and mildly reduce dejection fraction (EF).

Material and methods. The all-Russian prospective observational study BYHEART included 842 patients who underwent aEPCr therapy course. Before and after the course of EPCr therapy, the following studies were carried out: a questionnaire on the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the clinical assessment scale (CAS), transthoracic echocardiography with an assessment of the left ventricular EF, a 6-minute walk test, N-terminal pro-brain natriuretic peptide (NT-proBNP). All patients before the EPCr course received long-term optimal therapy for HF.

Results. Data analysis was carried out for patients in groups with heart failure with reduced ejection fraction (HFrEF) and with mildly reduced ejection fraction (HFmrEF) within the group depending on the course of EPCr treatment: subgroup A — patients who received EPCr therapy less than 20 g/course and subgroup B — patients who received EPCr therapy ≥20 g/course. The results obtained demonstrate an increase in the quality of life and exercise tolerance, an improvement according to the CAS, a decrease in NT-proBNP levels, and an improvement in left ventricular systolic function in patients with both HFrEF and HFmrEF during the course of intravenous EPCr therapy.

Conclusion. The use of EPCr is a promising tool in addition to optimal therapy in patients with HFrEF and HFmrEF.
PROMOTION OF POSITIVE PARENTING: THE PERCEPTION OF PRIMARY CARE NURSES
Authors: Reticena Kesley de Oliveira , Gomes Maria Fernanda Pereira , Fracolli Lislaine Aparecida
Published: December 2022

ABSTRACT Objective to understand nurses' perception regarding the necessary conditions for the promotion of positive parenting in assisting families with children aged from zero to three years old in Primary Care. Method this is a qualitative research study developed in a municipality from the inland of São Paulo, with participation of nine nurses who work in Primary Care. The data were collected from July to August 2021 by means of semi-structured interviews and analyzed based on the thematic modality of content analysis. Results the statements were organized in two categories: Necessary conditions for the Promotion of Positive Parenting in Primary Care; and Factors hindering the Promotion of Positive Parenting in Primary Care. Conclusion nurses realize the importance of building positive parenting through the development of parenting skills; however, they assume that they need more theoretical-practical knowledge to carry out care for this purpose and assert that the families' culture is not receptive to this type of care.