bluuebunny/crossref_metadata_2025 huggingface dataset:
A study of decay chains of radioactive actinium isotopes
Authors: Gupta P. S. Damodara , Sowmya N. , Manjunatha H. C. , Anushree H. S. , Seenappa L. , Sridhar K. N.
Published: December 2023

In this paper, we systematically studied half-lives of the different decay modes using various theoretical models such as the unified fission model (UFM) and the effective liquid drop model. Beta-decay half-lives were evaluated using semi-empirical formulae available in the literature. We compared half-lives of all the studied decay modes and identified shorter half-lives among the same in [Formula: see text]Ac nuclei. We investigated the actinium series which is similar to the thorium series. Among these decay series, alpha-emitting isotopes show great promise for cancer treatment because of their short path length and high-energy transfer of radiation. Furthermore, we predicted the decay chains of the actinium isotopes. All the decay series of actinium ends with the formation of stable nuclei or with longer half-lives. The predicted decay series and new isotopes during the decay process are helpful in the field of medicine and radiotherapy.
PREPARATION AND MODIFICATION OF CALCIUM PHOSPHATE CONVERSION COATING
Authors: MA CHI , SU ZHAOWEI , LI XUETIAN , SHAO ZHONGCAI
Published: December 2023

In order to enhance the corrosion resistance of calcium-based phosphate coating, the molybdenum-modified coating was successfully prepared by adding Na2MoO4 in a phosphate bath. The prepared composite film layers were studied by EDS, XRD and SEM. The corrosion resistance performances of the films were investigated by electrochemical measurements. The results showed the main composition of molybdenum-modified film was MoO2, MoP2, and MoP4, the diameter of cracks on the surface of the coating was significantly reduced, which provided better protection to the substrate. In addition, the potentiodynamic polarization curves of the molybdenum-modified film show that the corrosion potential was positively shifted by 0.068 V compared to the calcium-based phosphate coating and the corrosion current was reduced to 2.556 × 10[Formula: see text] A · cm[Formula: see text], indicating improved corrosion resistance.
Experimental Study on 3D RC Frame Structures with VE Energy Dissipation Braces Using STM32-Matlab-OpenSees Hybrid Test Platform
Authors: Dong Yao-Rong , Xu Zhao-Dong , Zhu Li-Hua , Li Qiang-Qiang , Xu Yeshou , Kong De-Yang , Cheng Yu
Published: December 2023

This study aims to reveal the control mechanism of viscoelastic (VE) energy dissipation braces with strong mechanical nonlinear characteristics on the seismic response of reinforced concrete (RC) frame structures. Firstly, a new STM32-Matlab-OpenSees joint hybrid test platform is developed by introducing OpenSees, which is convenient for structural modeling and fast for structural calculation. The overall architecture and operation of the hybrid test platform are comprehensively analyzed. Then, a series of simulated seismic hybrid tests on three-dimensional (3D) RC frame structures with VE energy dissipation braces under different seismic waves are successfully carried out. Lastly, the hybrid test results of this structure system at different working conditions are compared and analyzed comprehensively. The research results show that the developed platform breaks the boundary limitation that OpenSees relies on the framework software OpenFresco and can only be connected to specific control systems in the hybrid test. Thus, it greatly expands the application scope of flexible configuration controller and actuator categories for the hybrid test platform, and it also provides a good reference value for the establishment and implementation of similar hybrid test platforms. Under the action of various seismic waves, VE energy dissipation braces has good universality for the shock absorption of RC frame structures. The damping control effect and energy dissipation efficiency of VE energy dissipation braces are significantly different under various seismic waves. In the design of RC frame structures with VE energy dispersion braces, it is very necessary to conduct the seismic analysis of the structures under multiple ground motions with wide frequency domain. The additional position of VE energy dissipation braces should be an important analysis indicators in the optimization design of the structures.
Study of the Effect of Multi-Walled Carbon Nanotubes on the Mechanical Properties of Poly(Vinyl Alcohol)/Polyaniline Blend Film
Authors: Abdul-Hassan Ibrahim A. , Essa Abbas F. , Hameed Nahida J.
Published: December 2023

In this research, poly(vinyl alcohol)/polyaniline blend films were fabricated using solution casting technique with different weight ratios of PANI (2, 4, 6, 8, and 10) wt.%. The results showed that the best ratio of the polymer blend was (92% PVA/8% PANI), based on the electrical conductivity of direct current. The results showed that 8 wt.% PANI possessed the highest conductivity. Then, the composite films were prepared by adding multi-walled carbon nanotubes (MWCNT) to the optimum ratio of the polymer blend as a base material and at different weight ratios (0, 1, 3, 5, 7 wt.%). A tension device was used to examine and characterize the prepared samples. It was found that the addition of MWCNT to PVA/PANI caused an obvious decrease in elongation while there was an increase in tension strength and “Young’s modulus”. Optical microscopy results showed a good picture of the distribution of MWCNT particles for composites up to 1 wt.% MWCNT. But, some aggregations can be observed in films with 3, 5, and 7 wt.% MWCNT content.
ZMP — Where Are We After Fifty-Five Years?
Authors: Borovac Branislav , Nikolić Milutin , Raković Mirko , Savić Srđan
Published: December 2023

Twenty years ago in the first issue of IJHR, among others, there was a published paper [M. Vukobratović and B. Borovac, Zero-moment point — Thirty five years of its life, Int. J. Humanoid Robot. 1(1) (2004) 157–173], devoted to well-known zero-moment point (ZMP) concept. Its role in biped locomotion (in the preservation of dynamic balance during walking and gait synthesis) was (and still is) extremely significant. This paper is aimed to present, how far we have gone in the past 20 years in the realization of bipedal walking, what are remaining open challenges and what we can expect in the further development. At the beginning of the paper, we will briefly refer to some still existing misinterpretations of the ZMP notion, related to specific boundary cases, when the terms Center of Pressure (CoP) and ZMP are still being mixed. Then, we will point your attention to the discussion of two important issues: attempts of generalization of ZMP notion in case of motion in the presence of multiple, spatially distributed and non-planar contacts and walk realization in a non-laboratory environment (unstructured environment and on the non-flat ground surface). Of course, looking at “how humans do it” has always been an inspiration for the realization of complex tasks by humanoids. Learning to walk is a task where several successful realizations have appeared only recently, so we will look at this topic at the end of this paper.
A study of compact stars within Rastall gravity
Authors: Saleem Rabia , Aslam M. Israr , Shahid Shokaib
Published: December 2023

In this paper, we construct the exact interior solutions for compact stellar objects for perfect fluid distribution in phantom region in the framework of a non-conserved theory, i.e. Rastall gravity (RG). Under these circumstances, we develop the Einstein field equations (EFEs) for spherically symmetric metric using general forms of metric potentials, [Formula: see text] and [Formula: see text], here [Formula: see text] and [Formula: see text]. By matching of interior and exterior regions of the metric, we obtain the values of unknown constants of our considering model which helps to sketch the nature of important physical quantities like density, pressure, energy conditions, and stability. Finally, our obtained results lead us to conclude that our solutions are well behaved and physically viable for the specific choices of model parameters for two different stars (Vela X-1 and 4U1820-30).
Windy Postman Problem Under Uncertainty
Authors: Samanifar Samira , Ahmadzade Hamed , Nehi Hassan Mishmast
Published: December 2023

The postman problem is one of the optimization problems that has many applications in today’s world. With the progress of science, such optimization problems are used more. The postman’s problem is to find a route that has the minimum cost. The postman starts the route from one point and returns to the same point and must travel all the routes. If the round-trip costs are symmetric, in other words, the round-trip cost is the same, the problem is called the Chinese postman problem, and if the costs are asymmetric, that is, the round-trip cost is different from the return cost, the problem is called the windy postman problem (WPP). Here we describe two models of the WPP, which include the WPP and the rural WPP. The model for these problems in the real world needs to apply uncertainty theory. Liu expressed the theory of uncertainty. Here is a model of the windy postman uncertainty problem and a model of the windy rural postman uncertainty problem. So far, there has been no such uncertainty analysis on these models. To solve these problems, we use the Lagrangian heuristic method after turning it into a deterministic model. To solve these problems, after turning the problem into a deterministic problem, the heuristic Lagrangian method was used, and for the wind postman problem, we stated the corresponding Lagrangian algorithm and for the rural wind postman, the Lagrangian algorithm. Examples of these are problems and uncertainties. We expressed them and finally solved them by direct and Lagrangian methods.
Color-Tunable Emission of ZnO/Ag2O/MnO2 Nanocomposite Phosphor for Solid-State Lighting Applications
Authors: Ul Islam Shafi , Latief Urosa , Ali Javid , Khan Mohd. Shahid
Published: December 2023

For ecologically friendly and energy-efficient solid-state light sources, phosphors with low color-correlated temperatures (CCTs) and high color rendering indices (CRIs) are greatly desired. Herein, a co-precipitation method is used to modulate the fluorescence color of ZnO nano- material for bright multi-color light emitting diodes (LEDs) applications. The structural, thermal, morphological and optical properties of ZnO nanomaterials have been studied. Thermogravimetric analysis (TGA) of the as-synthesized nanomaterials reveals their good thermal stability whereas XPS analysis confirms their chemical states. We demonstrate that after combining ZnO with Ag2O and MnO2, the nanocomposite can attain extraordinary luminous tunability as realized by the photoluminescence (PL) properties of the nanomaterials. The estimated Commission Internationale de l’Eclairage (CIE) color coordinates indicate that ZnO, the blue color phosphor can be tuned to orange-red color phosphor (ZnO/Ag2O and ZnO/MnO[Formula: see text] and to white color phosphor (ZnO/Ag2O/MnO[Formula: see text] exhibits fairish color rendering index (CRI) of 84, after composited with Ag2O and MnO2. Finally, the ZnO/Ag2O, ZnO/MnO2 and ZnO/Ag2O/MnO2 nanocomposites have the potential to be utilized as phosphor materials in warm white LED applications because of their extremely pure, robust stability and tunable emission colors. Our findings can be used as a new benchmark for the identification of new phosphors and the tunability of their luminescent color for solid-state lighting applications.
On special solutions to the Ermakov–Painlevé XXV equation
Authors: Chichurin Alexander , Filipuk Galina
Published: December 2023

In this paper, we study a nonlinear second-order ordinary differential equation which we call the Ermakov–Painlevé XXV equation since under certain restrictions on its coefficients it can be reduced either to the Ermakov or the Painlevé XXV equation. The Ermakov–Painlevé XXV equation arises from a generalized Riccati equation and the related third-order linear differential equation via the Schwarzian derivative. The generalized Riccati equation has two families of Riccati solutions and we study the corresponding solutions to the Ermakov–Painlevé XXV equation. We show that one of these families appears only in the Ermakov case. We give examples of the Ermakov–Painlevé XXV equations and show how to construct their solutions expressed in terms of elementary or in terms of the classical special functions.
Forearm Deformities in Birth Brachial Plexus Palsy – Patient Profile and Management Algorithm
Authors: BHARDWAJ Praveen , VARADHARAJAN Vigneswaran , SALYAN Shrutikanth , VENKATRAMANI Hari , SABAPATHY S. Raja
Published: December 2023

Forearm deformities are often seen in children with severe birth brachial plexus palsy (BBPP). They may be either a supination or a pronation deformity and both hinder normal use of the hand and parents often request for corrective surgery. However, the correction of these deformities can be challenging due to a paucity of options. Also, there is less information in literature on the management of forearm deformities in BBPP compared to the information with regard to nerve surgery or correction of shoulder deformities. This article presents a synopsis of incidence, pathogenesis, clinical presentation and parental concerns related to these deformities. The decision-making considerations, management strategies and outcome expectations are also discussed. Patient selection is very crucial, and the treatment plan must be individualised depending on the disability, parental expectations and existing motor power in the involved limb. Correction of both the deformities have different considerations; however, effective correction of these deformities is immensely satisfactory to the patient/parents in terms of improved function and appearance of the limb.

Level of Evidence: Level V (Therapeutic)
Arthroscopic Dorsal Ligamentocapsulodesis in the Treatment of Occult Dorsal Wrist Ganglion Cysts Associated with Scapholunate Instability: Surgical Technique and Preliminary Clinical Results
Authors: AYIK Ömer , DEMİREL Mehmet , UĞURLAR Meriç , ÖZÇELİK İsmail Bülent
Published: December 2023

Background: This study aimed to evaluate our preliminary results and experience with the arthroscopic dorsal ligamentocapsulodesis in managing occult dorsal wrist ganglion cysts (ODGCs) associated with scapholunate (SL) instability.

Methods: All patients who underwent arthroscopic dorsal ligamentocapsulodesis due to an ODGC with concomitant SL ligament tear were retrospectively reviewed. In addition to demographic data and length of follow-up, outcomes data that included range of motion, grip strength, modified Mayo wrist score (MMWS), complications and radiographs were collected.

Results: The study included 18 patients (18 wrists; 10 female and 8 male). The mean age was 32 years (range: 19–48) and the mean follow-up was 34 months (range: 24–48). The mean preoperative extension deficit decreased from 5.5° (range: 0°–20°) to 2.7° (range: 0°–15°) at the final follow-up (p = 0.004). The mean preoperative flexion deficits decreased from 4.4° (range: 0°–15°) to 2.2° (range: 0°–10°) postoperatively (p = 0.003). The mean hand grip strength significantly increased from 27.7 kg (range: 22–36) to 38.3 kg (range: 31–46) at the final follow-up assessment (p < 0.001). The mean MMWS improved from 46 (range: 25–65) pre-operatively to 91 (range: 70–100) at the final follow-up (p = 0.0002). No major intra- or postoperative complications were observed.

Conclusions: SL instability may have an important role in the aetiology of ODGCs, and arthroscopic dorsal ligamentocapsulodesis can provide pain relief and functional improvement without recurrence at the short- to mid-term follow-up in the treatment of ODGCs.

Level of Evidence: Level IV (Therapeutic)
Fragment-Based Protein Structure Prediction, Where Are We Now?
Authors: Noor Qudsia , Kayode Raheem , Riaz Rizwan , Siddiqui Areeba , Mirza Aiza Hassan , Siddiqi Abdul Rauf
Published: December 2023

In the past decade, there has been an extensive advancement in the creation of methods for the design and prediction of protein structures. Expeditious growth in protein structure and sequence databases has charged the development of computational approaches for the prediction of structures. This review focuses on fragment-based strategy, a computational approach for the prediction of the three-dimensional structure of proteins. Fragment assembly has immensely improved protein structure prediction accuracy, especially of the single-domain proteins at the fold level. Fragment libraries are generated using the dihedral angles along with local structural information of known protein structures. This leads to the construction of a full-length polypeptide chain of a query protein using the fragments present in these libraries. The energy function of the proteins is minimized contributing to multiple conformations considering the backbone atoms and “centroid” side-chain pseudo-atoms using conformational sampling. Lastly, Monte Carlo simulation is performed for the sampling of the side-chain rotamers and reduction of energy for more precise and refined model construction. The quality of the fragments determines whether the native-like conformations generated are accurate or not. The future direction as well as tools like ROSETTA, QUARK, FRAGFOLD, M-TASSER, and AlphaFold2 that use fragment assembly for optimal structure prediction have also been described and compared in this review.
Spatiotemporal distribution of magmatism and crustal inheritance within an extensional–rotational environment: an updated geochronology of the Miocene and Quaternary magmatism of the South Apuseni Mountains
Authors: Ene V. V. , Tapster S. , Smith D. J. , Panaiotu C. , Roșu E. , Naden J. , Munteanu M.
Published: December 2023

Extension-related magmatism with arc-like features was active in the South Apuseni Mountains, Romania during the Neogene and Quaternary. The current chronological framework is primarily restricted to K–Ar dates. We present here new laser ablation inductively coupled plasma mass spectrometry U–Pb zircon age data for 20 subvolcanic and volcanic rocks from eight different Cenozoic volcanic–intrusive complexes and from Jurassic and Cretaceous lava flows. Our results support magmatic ages between
c.
14 and
c.
7 Ma, with Uroi, an alkaline intrusion, occurring significantly later at
c.
1.5 Ma. Revising the timeline for the South Apuseni Mountains palaeomagnetic rotations shows that most of the clockwise vertical-axis rotation of these mountains (54.4° ± 10.7°) took place between
c.
14 and 11 Ma, the age interval when the majority of the magmas were emplaced. Xenocrystic zircon dates show differences in the age populations between individual volcanic–intrusive complexes. A Permo-Triassic population is almost ubiquitous, indicating that basement Permo-Triassic igneous rocks are more widespread than previously thought, or that they were significantly involved in the generation of Neogene magmas. However, other observed age populations, such as Triassic or Paleogene, have no clear correspondence in the known geological record, indicating the presence of a cryptic component interacting with Neogene magmas.

Supplementary material:
Full analytical details and age calculations for the U–Pb age data collected during this study, rock samples and separated zircon fraction descriptions and the palaeomagnetic and age databases are available at
https://doi.org/10.6084/m9.figshare.c.6951429
Late Cryogenian and early Ediacaran rare-metal rich granites in the Eastern Desert of Egypt: constraints from zircon ages and whole-rock Sr- and Nd- and feldspar Pb-isotopic compositions
Authors: Stern Robert James , Khedr Mohamed Zaki , Whitehouse Martin J. , Romer Rolf L. , Khashaba Saif M. Abo , El-Shibiny N. H.
Published: December 2023

Rare metals (Nb, Ta, Y, Zr, Sn, U, W and REE) are economically important and new supplies need to be found. In order to understand Neoproterozoic rare metal granites of the Arabian–Nubian Shield (ANS), six samples from five rare-metal mineralized alkali feldspar granites, syenogranites and granodiorite from the Central and SE Desert of Egypt were studied for zircon U–Pb ages and O-isotopic compositions as well as whole-rock Sr- and Nd- and alkali feldspar Pb-isotopic compositions. These are transitional between I-type and A-type granites, mostly high-K calc-alkaline, peraluminous granites with gullwing-shaped REE patterns and strongly negative Eu anomalies. Four granites gave mantle-like zircon

δ

18
O
V-SMOW
between 4.2 and 5.96‰ and yielded ages of 628–633 Ma. This is about when subduction-related magmatism began to be replaced by collision-related magmatism. Igla Ahmr granites are older, formed at 691.7–678.9 Ma with

δ

18
O
V-SMOW
c
. 5.95‰. All have positive initial

ε

Nd
values (+3.3 to +6.9) typical for mantle and juvenile crust. Pb isotopic compositions are unusually radiogenic compared with unmineralized ANS granitic rocks. The data indicate similar magmatic sources for ANS mineralized and unmineralized granites. Exploration for other rare-metal mineralized granites in the ANS should focus on bodies with similar characteristics.

Supplementary material
: Details of analytical details and supplementary tables and figures are available at
https://doi.org/10.6084/m9.figshare.c.6949402
The presence of cystic fibrosis-related diabetes modifies the sputum microbiome in cystic fibrosis disease
Authors: Vasiljevs Stanislavs , Witney Adam A. , Baines Deborah L.
Published: December 2023

Cystic fibrosis-related diabetes (CFRD) is associated with a decline in respiratory health. We show for the first time that there was a change in the sputum microbiome of people with CFRD compared with CF that correlated with markers of raised blood glucose.
Extracellular vesicles secreted by primary human bronchial epithelial cells reduce Pseudomonas aeruginosa burden and inflammation in cystic fibrosis mouse lung
Authors: Sarkar Sharanya , Barnaby Roxanna , Nymon Amanda B. , Taatjes Douglas J. , Kelley Thomas J. , Stanton Bruce A.
Published: December 2023

Our findings show that extracellular vesicles secreted by primary human bronchial epithelial cells significantly reduce Pseudomonas aeruginosa burden, inflammation, and weight loss in a cystic fibrosis mouse model of infection.
miR-29c Inhibits Renal Interstitial Fibrotic Proliferative Properties through PI3K-AKT Pathway
Authors: Feng Weifeng , Xie Huijun , Li Jiong , Yan Xianxin , Zhu Shiping , Sun Shengyun
Published: December 2023

Renal fibrosis, in particular tubulointerstitial fibrosis, which is characterized by an increased extracellular matrix (ECM) formation and development in the interstitium, is the common end pathway for nearly all progressive kidney disorders. One of the sources for this matrix is the epithelial to mesenchymal transition (EMT) from the tabular epithelium. The driving force behind it is some profibrotic growth factors such as transforming growth factor-β (TGF-β) which is responsible for the formation of collagen in renal fibrosis. miR-29c, which is an antifibrotic microRNA, downregulates renal interstitial fibrosis by downregulating the TGF-β and collagen. However, it is not known whether miR-29c mediates the TGF-β1-driven PI3K-Akt pathway and Col-1 triggering within NRK-52E cultures. The main objective of this investigation was to examine the influence of miR-29c on the downregulation of the TGF-β1-driven PI3K-Akt pathway and Col-1 triggering in NRK-52E cultures. This study revealed that miR-29c inhibited TGF-β1 expression in NRK-52E cell cultures. Overexpression of miR-29c significantly inhibits NRK-52E culture proliferation mediated by TGF-β1. miR-29c inhibited the expression of Col-1 and decreased PI3K/Akt phosphorylation. These findings revealed a novel mechanism by which miR29c inhibits the proliferation of renal interstitial fibrotic cultures by downregulating the PI3k-Akt pathway, which is controlled by TGF-β1.
The Oncogenic Role of KLF7 in Colon Adenocarcinoma and Therapeutic Perspectives
Authors: Li Zhenjia , Liu Qi
Published: December 2023

Colon adenocarcinoma, a highly prevalent and aggressive form of colorectal cancer, necessitates a comprehensive understanding of its molecular mechanisms to identify potential therapeutic targets. The Krüppel-like factor 7 (KLF7), a transcription factor, has been associated with various malignancies, yet its specific role in colon adenocarcinoma remains largely unexplored. Here, we aimed to determine the expression and functional significance of KLF7 in colon adenocarcinoma. Our findings revealed a significant upregulation of KLF7 expression in colon adenocarcinoma tissues compared to adjacent normal tissues. Moreover, elevated KLF7 expression correlated with advanced tumor stage, lymph node metastasis, and poor overall survival in colon adenocarcinoma patients. Functional assays demonstrated that silencing KLF7 resulted in reduced cell proliferation, migration, and invasion, indicating its involvement in promoting tumor growth and metastasis. Additionally, we identified potential downstream targets of KLF7, including genes associated with cell cycle regulation and epithelial-mesenchymal transition. These results underscore the tumor-promoting role of KLF7 in colon adenocarcinoma, positioning it as a potential prognostic biomarker and therapeutic target for this aggressive disease.
Comparative Analysis of Hypertension Guidelines: Unveiling Consensus and Discrepancies in Lifestyle Modifications for Blood Pressure Control
Authors: Wang Yi , Liu Yanxiang , Liu Lu , Hong Liqiong , Chen Huimin
Published: December 2023

Background. Hypertension is a major global health concern, and lifestyle modifications have been recommended as first-line treatment for hypertension in many guidelines. However, different guidelines may recommend different types of lifestyle adjustment, and it is unclear which ones are most effective. In this review, we compared hypertension guidelines to identify any differences and/or consensus in content, efficacy, and timing of initiation of lifestyle modifications. Methods. We conducted a search of databases to identify hypertension guidelines available in English. We extracted and compared information about lifestyle modifications recommended by the guidelines. Results. Five hypertension guidelines from America, Europe, the UK, Canada, and the International Society of Hypertension are included. They all recommend diet adaptation, sodium reduction, alcohol restriction, physical exercise, and weight reduction. Other lifestyle interventions emphasized by some guidelines, such as potassium supplementation, smoking cessation, and stress management, are not recommended by all the five guidelines. Among lifestyle changes, the dietary approaches to stop hypertension (DASH) diet may be considered the most effective treatment for reducing blood pressure. These guidelines recommend that for patients with high-normal blood pressure or grade 1 hypertension without high risk factors, lifestyle medicine should be used first for 3–6 months, if blood pressure is still not controlled, then start medication. For those patients who need drug treatment, lifestyle changes can also enhance the effects of antihypertensive therapy. Conclusion. Lifestyle modifications are crucial in the treatment of hypertension and should be recommended to most hypertensive patients. Among these lifestyle interventions, diet adaptation containing low sodium and alcohol restriction may be the most effective in reducing blood pressure. Physical exercise and weight reduction are also recommended. In some cases, lifestyle modifications should be tried first. They may also enhance the effects of antihypertensive drugs in other patients.
Implications and Mechanisms of Antiviral Effects of Lactic Acid Bacteria: A Systematic Review
Authors: Farahmandi Fargol , Parhizgar Parynaz , Mozafari Komesh Tape Parya , Bizhannia Fahimeh , Rohani Fateme Sadat , Bizhanzadeh Marzieh , Mostafavi Alhosseini Zeinab Sadat , Hosseinzade Maede , Farsi Yeganeh , Nasiri Mohammad Javad
Published: December 2023

Background. Lactic acid bacteria (LAB) are among the most important strains of probiotics. Some are normal flora of human mucous membranes in the gastrointestinal system, skin, urinary tract, and genitalia. There is evidence suggesting that LAB has an antiviral effect on viral infections. However, these studies are still controversial; a systematic review was conducted to evaluate the antiviral effects of LAB on viral infections. Methods. The systematic search was conducted until the end of December 17, 2022, using international databases such as Scopus, Web of Science, and Medline (via PubMed). The keywords of our search were lactic acid bacteria, Lactobacillales, Lactobacillus (as well as its species), probiotics, antiviral, inhibitory effect, and virus. Results. Of 15.408 potentially relevant articles obtained, 45 eligible in-vivo human studies were selected for inclusion in the study from databases, registers, and citation searching. We conducted a systematic review of the antiviral effects of the LAB based on the included articles. The most commonly investigated lactobacillus specie were Lactobacillus rhamnosus GG and Lactobacillus casei. Conclusion. Our study indicates that 40 of the selected 45 of the included articles support the positive effect of LAB on viral infections, although some studies showed no significant positive effect of LABs on some viral infections.
Sugar-Sweetened Beverages Consumption and Breast Cancer in Premenopausal and Postmenopausal Women
Authors: Garduño-Alanis Adriana , Ángeles-Llerenas Angélica , Sánchez-Zamorano Luisa María , Flores-Luna Lourdes , Flores-Aldana Mario , Torres-Mejía Gabriela
Published: December 2023

Background:

The consumption of sugar-sweetened beverages (SSB), of which Mexico is a large consumer, has been associated with the risk of breast cancer. We assessed the association between SSBs consumption and breast cancer risk in pre- and postmenopausal women.

Methods:

We performed a multicenter population-based case–control study in Mexico City, Monterrey, and Veracruz. We recruited 1,000 cases and 1,074 controls; all participants were pre- or postmenopausal women between 35 and 69 years of age. Diet before symptoms onset was assessed using a food frequency questionnaire. We conducted a multivariable-adjusted conditional logistic regression analysis stratified by menopausal status.

Results:

For premenopausal women, after adjusting for matching characteristics, total energy intake and all potential confounders, the odds of having breast cancer in women who drank one or more SSBs servings per day showed 1.78 times the odds of those who drank one or fewer SSBs servings per month [OR = 1.78; 95% confidence interval (CI), 1.06–3.01]. For postmenopausal women, the corresponding model was not statistically significant (OR = 1.38, 95% CI, 0.84–2.25). We also observed higher consumption of SSBs among pre- than in postmenopausal women (23.3% and 17.4%, respectively among controls in the highest consumption category (≥1 per day).

Conclusions:

Our results suggest that SSBs consumption increases the risk of developing breast cancer, particularly in premenopausal women.

Impact:

Given the consumption of SSBs, of which Mexico is a large consumer, these results can support public policies to discourage the consumption of SSBs.
Mitochondria Transfer by Platelet-Derived Microparticles Regulates Breast Cancer Bioenergetic States and Malignant Features
Authors: Veilleux Vanessa , Pichaud Nicolas , Boudreau Luc H. , Robichaud Gilles A.
Published: December 2023

An increasing number of studies show that platelets as well as platelet-derived microparticles (PMP) play significant roles in cancer malignancy and disease progression. Particularly, PMPs have the capacity to interact and internalize within target cells resulting in the transfer of their bioactive cargo, which can modulate the signaling and activation processes of recipient cells. We recently identified a new subpopulation of these vesicles (termed mitoMPs), which contain functional mitochondria. Given the predominant role of mitochondria in cancer cell metabolism and disease progression, we set out to investigate the impact of mitoMPs on breast cancer metabolic reprograming and phenotypic processes leading to malignancy. Interestingly, we observed that recipient cell permeability to PMP internalization varied among the breast cancer cell types evaluated in our study. Specifically, cells permissive to mitoMPs acquire mitochondrial-dependent functions, which stimulate increased cellular oxygen consumption rates and intracellular ATP levels. In addition, cancer cells co-incubated with PMPs display enhanced malignant features in terms of migration and invasion. Most importantly, the cancer aggressive processes and notable metabolic plasticity induced by PMPs were highly dependent on the functional status of the mitoMP-packaged mitochondria. These findings characterize a new mechanism by which breast cancer cells acquire foreign mitochondria resulting in the gain of metabolic processes and malignant features. A better understanding of these mechanisms may provide therapeutic opportunities through PMP blockade to deprive cancer cells from resources vital in disease progression.

Implications:

We show that the transfer of foreign mitochondria by microparticles modulates recipient cancer cell metabolic plasticity, leading to greater malignant processes.
Supplementary Figure S4 from Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression
Authors: Hsu Wen-Hao , LaBella Kyle A. , Lin Yiyun , Xu Ping , Lee Rumi , Hsieh Cheng-En , Yang Lei , Zhou Ashley , Blecher Jonathan M. , Wu Chang-Jiun , Lin Kangyu , Shang Xiaoying , Jiang Shan , Spring Denise J. , Xia Yan , Chen Peiwen , Shen John Paul , Kopetz Scott , DePinho Ronald A.
Published: December 2023

Figure S4 illustrates how lipid-rich CAFs contribute to tumor
progression.
Supplementary Table S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Authors: Bercier Pierre , Wang Qian Qian , Zang Ning , Zhang Jie , Yang Chang , Maimaitiyiming Yasen , Abou-Ghali Majdouline , Berthier Caroline , Wu Chengchen , Niwa-Kawakita Michiko , Dirami Thassadite , Geoffroy Marie-Claude , Ferhi Omar , Quentin Samuel , Benhenda Shirine , Ogra Yasumitsu , Gueroui Zoher , Zhou Chun , Naranmandura Hua , de Thé Hugues , Lallemand-Breitenbach Valérie
Published: December 2023

Table displaying all the reagents used in this study with information regarding the supplier, catalog number and RRID (antibodies).
Supplementary Movie S2 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Authors: Bercier Pierre , Wang Qian Qian , Zang Ning , Zhang Jie , Yang Chang , Maimaitiyiming Yasen , Abou-Ghali Majdouline , Berthier Caroline , Wu Chengchen , Niwa-Kawakita Michiko , Dirami Thassadite , Geoffroy Marie-Claude , Ferhi Omar , Quentin Samuel , Benhenda Shirine , Ogra Yasumitsu , Gueroui Zoher , Zhou Chun , Naranmandura Hua , de Thé Hugues , Lallemand-Breitenbach Valérie
Published: December 2023

Supplementary movie 2 shows Incomplete PML NBs fusion upon ATO treatment (1µM, 1h) in MEFs
Supplementary Figure S1 from Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Authors: Bercier Pierre , Wang Qian Qian , Zang Ning , Zhang Jie , Yang Chang , Maimaitiyiming Yasen , Abou-Ghali Majdouline , Berthier Caroline , Wu Chengchen , Niwa-Kawakita Michiko , Dirami Thassadite , Geoffroy Marie-Claude , Ferhi Omar , Quentin Samuel , Benhenda Shirine , Ogra Yasumitsu , Gueroui Zoher , Zhou Chun , Naranmandura Hua , de Thé Hugues , Lallemand-Breitenbach Valérie
Published: December 2023

Figure S1 illustrates LLPS hallmarks of PML nuclear bodies and highlights that their assembly does not rely on intermolecular disulfide bonds
Supplementary Table S3 from p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression
Authors: Efe Gizem , Dunbar Karen J. , Sugiura Kensuke , Cunningham Katherine , Carcamo Saul , Karaiskos Spyros , Tang Qiaosi , Cruz-Acuña Ricardo , Resnick-Silverman Lois , Peura Jessica , Lu Chao , Hasson Dan , Klein-Szanto Andres J. , Taylor Alison M. , Manfredi James J. , Prives Carol , Rustgi Anil K.
Published: December 2023

Supplementary Table S3. Statistics of aligned reads from the CUT&RUN-seq analysis of H3K27ac in ESCC cells with Trp53R172H/- (n=3) and Trp53+/+ (n=2).
Data from Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression
Authors: Hsu Wen-Hao , LaBella Kyle A. , Lin Yiyun , Xu Ping , Lee Rumi , Hsieh Cheng-En , Yang Lei , Zhou Ashley , Blecher Jonathan M. , Wu Chang-Jiun , Lin Kangyu , Shang Xiaoying , Jiang Shan , Spring Denise J. , Xia Yan , Chen Peiwen , Shen John Paul , Kopetz Scott , DePinho Ronald A.
Published: December 2023

Abstract
Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer, KRAS* suppresses antitumor immunity to promote tumor invasion and metastasis. Here, we uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAF) into lipid-laden CAFs, promoting angiogenesis and tumor progression. Mechanistically, KRAS* activates the transcription factor CP2 (TFCP2) that upregulates the expression of the proadipogenic factors BMP4 and WNT5B, triggering the transformation of CAFs into lipid-rich CAFs. These lipid-rich CAFs, in turn, produce VEGFA to spur angiogenesis. In KRAS*-driven colorectal cancer mouse models, genetic or pharmacologic neutralization of TFCP2 reduced lipid-rich CAFs, lessened tumor angiogenesis, and improved overall survival. Correspondingly, in human colorectal cancer, lipid-rich CAF and TFCP2 signatures correlate with worse prognosis. This work unveils a new role for KRAS* in transforming CAFs, driving tumor angiogenesis and disease progression, providing an actionable therapeutic intervention for KRAS*-driven colorectal cancer.
Significance:
This study identified a molecular mechanism contributing to KRAS*-driven colorectal cancer progression via fibroblast transformation in the tumor microenvironment to produce VEGFA driving tumor angiogenesis. In preclinical models, targeting the KRAS*–TFCP2–VEGFA axis impaired tumor progression, revealing a potential novel therapeutic option for patients with KRAS*-driven colorectal cancer.

This article is featured in Selected Articles from This Issue, p. 2489
Supplementary Table 1 from Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance
Authors: Banerjee Debarshi , Boboila Shuobo , Okochi Shunpei , Angelastro James M. , Kadenhe-Chiweshe Angela V. , Lopez Gonzalo , Califano Andrea , Connolly Eileen P. , Greene Lloyd A. , Yamashiro Darrell J.
Published: December 2023

Supplementary Table 1. List of antibodies used in this study
Supplementary Figure 5 from Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance
Authors: Banerjee Debarshi , Boboila Shuobo , Okochi Shunpei , Angelastro James M. , Kadenhe-Chiweshe Angela V. , Lopez Gonzalo , Califano Andrea , Connolly Eileen P. , Greene Lloyd A. , Yamashiro Darrell J.
Published: December 2023

Supplementary Figure 5 shows that overexpression of ATF5 promotes anoikis resistance of CHLA-255 in vitro
Supplementary Figure 2 from Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance
Authors: Banerjee Debarshi , Boboila Shuobo , Okochi Shunpei , Angelastro James M. , Kadenhe-Chiweshe Angela V. , Lopez Gonzalo , Califano Andrea , Connolly Eileen P. , Greene Lloyd A. , Yamashiro Darrell J.
Published: December 2023

Supplementary Figure 2 shows that ATF5 knockdown decreases neuroblastoma cell viability and promotes apoptosis under adherent conditions
Contemplation of the Effect of Nivolumab Plus Cabosantinib Therapy on Cerebral Hemorrhage in Patients with Brain Metastasis of Renal Cell Carcinoma: A Case Report
Authors: Sato Yasufumi , Kawasaki Yoshihide , Satake Yohei , Shimoda Yoshiteru , Katayama Hiromichi , Sato Takuma , Shimada Shuichi , Kawamorita Naoki , Yamashita Shinichi , Kanamori Masayuki , Ito Akihiro
Published: December 2023

Although the response to combination therapy has been reported in patients with brain metastases from advanced renal cancer, treatment-related cerebral hemorrhage has not been adequately studied. The CheckMate 9ER clinical trial of nivolumab and cabozantinib excluded patients with brain metastases. Therefore, the associated treatment outcomes in these patients with brain metastases are unclear. Herein, we report a case of bleeding from brain metastases in a patient with advanced renal cancer after gamma knife combination therapy with nivolumab and cabozantinib. Fortunately, the cerebral hemorrhage of the patient was alleviated by conservative treatment. Despite treatment interruption, the metastatic lesions reduced in size, and treatment was gradually resumed. In this case study, we report the risk of cerebral hemorrhage in combination therapy for brain metastasis cases, how to manage hemorrhage cases, and their prognosis.
Perspectives of Implementation of Closed-Loop Deep Brain Stimulation: From Neurological to Psychiatric Disorders
Authors: Groppa Sergiu , Gonzalez-Escamilla Gabriel , Tinkhauser Gerd , Baqapuri Halim Ibrahim , Sajonz Bastian , Wiest Christoph , Pereira Joana , Herz Damian M. , Dold Matthias R. , Bange Manuel , Ciolac Dumitru , Almeida Viviane , Neuber John , Mirzac Daniela , Martín-Rodríguez Juan Francisco , Dresel Christian , Muthuraman Muthuraman , Adarmes Gomez Astrid D. , Navas Marta , Temiz Gizem , Gunduz Aysegul , Rotaru Lilia , Winter Yaroslav , Schuurman Rick , Contarino Maria F. , Glaser Martin , Tangermann Michael , Leentjens Albert F.G. , Mir Pablo , Torres Diaz Cristina V. , Karachi Carine , Linden David E.J. , Tan Huiling , Coenen Volker A. ,   on behalf of the EuroDBS
Published: December 2023

Background: Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy to alleviate symptoms and improve quality of life in movement disorders such as Parkinson’s disease, essential tremor, and dystonia, which is also being applied in several psychiatric disorders, such as obsessive-compulsive disorder and depression, when they are otherwise resistant to therapy. Summary: At present, DBS is clinically applied in the so-called open-loop approach, with fixed stimulation parameters, irrespective of the patients’ clinical state(s). This approach ignores the brain states or feedback from the central nervous system or peripheral recordings, thus potentially limiting its efficacy and inducing side effects by stimulation of the targeted networks below or above the therapeutic level. Key Messages: The currently emerging closed-loop (CL) approaches are designed to adapt stimulation parameters to the electrophysiological surrogates of disease symptoms and states. CL-DBS paves the way for adaptive personalized DBS protocols. This review elaborates on the perspectives of the CL technology and discusses its opportunities as well as its potential pitfalls for both clinical and research use in neuropsychiatric disorders.
Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report
Authors: Ikuno Yasuaki , Kokubu Hiraku , Kato Miwa , Okada Kazuma , Yamaguchi Akihiko , Takahashi Toshifumi , Kato Takeshi , Fujimoto Noriki
Published: December 2023

Introduction: Regression of malignant melanoma (MM) is a commonly observed phenomenon, which refers to disappearance or loss of all or part of MM. It can be identified both clinically and histologically, and high probability of histological regression of MM (10–58%) has been reported. However, the decapitation of skin tumor has rarely been described in the English literature, and decapitation in MM has not been reported. Here, we report the case of polypoid MM with spontaneous decapitation. Case Presentation: An 81-year-old Japanese woman was referred to our hospital due to a polypoid nodule on her cheek. She was diagnosed with MM at stage IIC (T4bN0M0) by histological examinations. Three weeks after the biopsy, the nodule decapitated spontaneously without bleeding, and an ulcer developed on the base of the polypoid nodule. The histological examination of the additionally resected ulcerative lesion under the nodule revealed infiltration of T cells mainly composed of CD8⁺ natural killer T cells. No recurrence or metastasis has been observed for 4 years. Conclusion: This is the first case report of polypoid MM with spontaneous decapitation, which may be attributed to natural killer T cells. Moreover, this case shows favorable prognosis, while it is said that the regression in thick MM does not have prognostic advantage and polypoid topography has been reported to be related to extremely poor prognosis. Further investigations are needed to evaluate the prognostic advantage of decapitation in MM and other skin tumors.
Abstract 14908: The Impact of Virtual Reality on Early Rehabilitation in Cardiac Intensive Care Units
Authors: Wang Mei-Tzu , Huang Wei-Chun
Published: December 2023

Introduction:
The early mobilization of patients in the intensive care unit (ICU) was shown to be important in patients’ recovery.

Hypothesis:
The aim of this study in to investigate the impact of virtual reality (VR) on early rehabilitation in cardiac intensive care units.

Methods:
The consecutive patients in adult cardiac intensive care units were enrolled. The patients were divided into two groups VR rehabilitation group and control group. The patients in VR rehabilitation group received respiratory, functional training with virtual reality (VR). Maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), SF-36, ICU stay and intubation days were collected.

Results:
After VR training, the maximal inspiratory pressure (MIP) showed significant improvement (
p
=0.0088) and maximal expiratory pressure (MEP) also improved significantly (
p
=0.0203). Further, VR rehabilitation group also had better Barthel index (
p
<0.0001), intensive mobility scale (
p
<0.0001), shorter ICU stay (
p
=0.0063), and intubation days (
p
=0.006).

Conclusions:
This study demonstrate VR rehabilitation in cardiac intensive care units improved exercise capacity, Barthel index, intensive mobility scale, ICU stay and intubation days.