bluuebunny/crossref_metadata_2025 huggingface dataset:
Peranan Kepemimpinan Perempuan dan Motivasi Kerja dalam Meningkatkan Kinerja Pemerintahan Desa
Authors: Novaliana Ika , Siskawati Titin Intan
Published: May 2023

Women have more challenges when they want to take part in village governance, especially from the point of view of those whose cultural norms have not been adhered to. To achieve this, the main objective of this study is to identify and examine the factors that contribute to effective village governance. by identifying the contribution of the female village head as a leader and providing incentives for village officials to carry out their duties. A quantitative approach was taken for this investigation to ensure reliable findings. Observations, questionnaires, validation tests, and reliability tests are used in gathering information.

In this investigation, surveys were distributed using Google forms, providing primary data. Researchers in this study selected participants randomly, not by chance. from the target group (village heads and other village officials) totaling 44 participants. Primary data were collected through well-designed surveys and trials, then multiple regression analysis was used to describe the results.

This study found that women's leadership styles can have a good and large impact on the efficiency of local government in villages. Meanwhile, the efficiency of village administration increased slightly when workers were encouraged to do their best. Both the leadership style and work motivation of women have a positive and significant impact on the efficiency and effectiveness of village government, so that it can better serve local communities.
Challenges of Clinical Teaching in Developing Countries
Authors: Drateru Keren Carol
Published: May 2023

Clinical teaching is very important for students’ learning as it helps them to integrate cognitive, affective and psychomotor skills when delivering medical care. However, it has been noted that across all medical fields new graduates have low level of competency and questions have been raised with regard to the contributing challenges. This paper aimed at exploring the challenges that affect clinical teaching in the developing countries. A Google search of the published article on challenges of clinical teaching in the developing countries was done and the reported factors were documented. The challenges found included: poor teachers’ knowledge and skills, finance related constraints, unfavorable learning environment, large numbers of enrolled students and the accompanying constraints, poorly motivated teachers and poor government policies. Based on these findings, it is recommended that efforts need to be made to address the challenges so as to enable effective clinical teaching that will roll out health workers who can offer appropriate services to society.
Pelatihan Digital Marketing untuk Meningkatkan Penjualan Produk Pertanian Kelompok Tani Wanita Permata Indah Desa Selur
Authors: Rizal Fitra , Prayoga Dhimas Haryo , Amalia Diah Ihdini , Rosanti Diah Ayu , Anggrahini Endriana Nur , Andini Erika Mega Wahyu
Published: May 2023

The Permata Indah Women Farmers Group in Selur Village was established in 2011 with the aim of empowering housewives and boosting the family economy. Activities at the Women's Farmer Group (KTW) are in the form of processing plantation products in the form of bananas into processed foods such as chips and banana sale. Since the Covid-19 pandemic began to spread in the Ponorogo Regency area, the level of sales has also decreased because the sales system still does not use social media. As a result, production activities are also stopped to avoid losses. But now, after almost 2 years of production stopping and the pandemic starting to improve, the enthusiasm of the mothers has decreased. Therefore, we have the initiative to hold a training which was attended by 20 participants with the theme of digital marketing to provide new business innovations through digital platforms. The purpose of this training is to provide knowledge about digital marketing based on social media and increase sales of women's farmer groups' products. This activity uses an asset-based community-development (ABCD) approach to optimize existing assets and potential. The end result of this activity is that the trainees can create and operate social media accounts in the form of WhatsApp Business and Instagram Business. Thus, it is hoped that it can improve the economy for the Permata Indah Women Farmer Group in Selur Village. The trainees also felt satisfied and more motivated to restart production that had stopped.
Senam Hamil dan Penyuluhan Tanda-Tanda Persalinan Melalui Pelaksanaan Kelas Ibu Hamil di Kelurahan Sidanegara RT 02 RW 012 Kecamatan Cilacap Tengah Kabupaten Cilacap
Authors: Elifiya Elifiya , Amelia Marsela , Dianti Dianti , Yunadi Frisca Dewi , Budiarti Tri , Kusumawati Dhiah Dwi
Published: May 2023

Pregnant women often experience many changes, both physical changes and psychological changes. Pregnancy exercises performed during pregnancy can help women focus on the labor process, prepare to tolerate pain, and convert stress and anxiety into energy. The purpose of this Community Midwifery Practice activity is to provide opportunities for pregnant women in Sidanegara Village to be precise on Rt 02 Rw 012, Central Cilacap District, Cilacap Regency. To understand the changes that occur during pregnancy and be able to prepare for the delivery process through Pregnancy Exercises. Sidanegara Village Precisely on Rt 02 Rw 012 Central Cilacap District, Cilacap Regency which was held on December 2, 2021. In this PKM, pregnant women received a positive response. Pregnant women seemed to be asking questions about the counseling provided and when participating in Pregnancy Exercises they seemed enthusiastic in the level of movement of the ability of pregnant women to do pregnancy exercise and the level of knowledge of the mother about the practice of pregnant exercise so that by carrying out this pregnancy exercise there is an increase in knowledge of pregnant women and the results of the increase after an evaluation of pregnant exercise are categorized as good, while the results l evaluation of counseling on signs of labor, i.e. pregnant women already know about the signs of labor
Meningkatkan Nilai-Nilai Religius Anak Melalui Pendampingan Pembelajaran Al-Quran di TPQ Sabilil Huda Desa Bedingin, Ponorogo
Authors: Witasari Rinesti , Fathoni Khoirul , Albab Ibrotuli Ulil
Published: May 2023

Learning the Qur'an is very important, especially for children. In this activity, developing a sense of love for the Qur'an, the learning of the Qur'an should be instilled from an early age so that when they are old they are able to carry out the religious values ​​contained in the Qur'an in their daily lives. Al-Qur'an learning in the Bedingin village environment is said to be very lacking due to lay parents who do not understand the Qur'an, as well as the lack of educators to teach al-Qur'an learning, and also the lack of adequate places for learning the Qur'an. the. Emerged from the enthusiasm and enthusiasm of children to learn the Koran and the importance of learning the Koran is taught. This KPM activity contributes to children by providing learning and knowledge about the importance of the Qur'an to be studied and practiced in everyday life. By doing this activity, we get positive support and attention from the local community. The result of this activity is that many children are enthusiastic and enthusiastic in learning the Koran, increasing knowledge and knowledge about the Qu’ran for children.
Revisitando o conceito de patrimônio geológico: pela superação da dicotomia entre o natural e o cultural
Authors: Beil Isabella Maria
Published: May 2023

O patrimônio geológico, entendido como um conceito emergente, tem se ampliado consideravelmente no debate acadêmico desde a década de 1990. Entretanto, é comumente abordado como um objeto autônomo a outras categorias patrimoniais, como a natural e a cultural. Além disso, permanecem constantes as tentativas de torná-lo mais integrado à sociedade em geral, buscando modos de “traduzir” a linguagem geológica ao público leigo. Levando essas problemáticas em consideração, este artigo possui como objetivo discutir o conceito de patrimônio geológico e seus significados, propondo uma interpretação que ressalte os seus vínculos e conexões com o chamado patrimônio cultural e que o considere para além do objeto geológico em si. Para cumprir esse objetivo, o artigo está baseado em uma investigação teórica e qualitativa que parte de uma retomada histórica sobre o termo “patrimônio” e busca em suas raízes dados para pensar o modo que este é interpretado contemporaneamente. Em seguida, é explorada a emergência do patrimônio geológico e suas profundas relações e convergências com o chamado patrimônio cultural. Por fim, é exposta uma breve recuperação da experiência brasileira com a chancela de Paisagem Cultural e sua afinidade com as temáticas dos Geoparques e do patrimônio geológico.
Må Danmark true, lyve og vildlede? Påvirkningsoperationer set fra et retligt perspektiv
Authors: Schack Marc
Published: May 2023

En retsstat som Danmark er karakteriseret ved sit demokratiske ophav, lighed for loven og beskyttelsen af fundamentale frihedsrettigheder. Det står i kontrast til andre statstyper, hvor sådanne elementer er enten fraværende eller nedprioriterede. Spørgsmålet er, hvilken betydning dén kontrast har for retsstatens evne til at operere inden for informationsområdet og henholdsvis udføre eller imødegå påvirkningsoperationer. Med udgangspunkt i en analyse af centrale dele af det retsgrundlag, som den danske stat er forpligtet på, analyseres Danmarks evne til at håndtere sådanne operationer. Da emnet dog principielt er ganske omfattende, fokuserer artiklen på tre juridiske problemstillinger: Offentlige myndigheders sandhedspligt, folkerettens suverænitetsprincip og den folkeretlige regulering af magtanvendelse og krigsførelse.
O “tempo ótimo” para a reinserção familiar: um estudo de caso de um adolescente institucionalizado
Authors: Almeida Sara Guerra Carvalho de , Morais Normanda Araujo de
Published: May 2023

A reinserção familiar (RF) é um processo complexo que implica demandas do adolescente acolhido, sua família, normas institucionais e da legislação, que estabelece o tempo máximo de dois anos para a medida protetiva de acolhimento. O artigo objetivou apresentar e discutir um estudo de caso de um adolescente (15 anos), problematizando o “tempo ótimo” para a RF, a partir da sua perspectiva, da sua mãe e de um educador social, em três momentos (um mês antes da saída da instituição, um mês após e seis meses após o retorno para o contexto familiar). Verificou-se que o tempo de institucionalização excedeu em três vezes a normativa legal sobre o prazo máximo de acolhimento, bem como a existência de um descompasso entre os tempos dos diferentes personagens envolvidos. Reforça-se a necessidade da preparação contínua, da família e do adolescente, bem como o fortalecimento da rede de proteção, tão logo inicie a institucionalização.
Violência conjugal e coping: a negação como estratégia de enfrentamento à violência por mulheres heterossexuais
Authors: Neis Letícia Ferraz , Falcke Denise
Published: May 2023

O fenômeno da violência conjugal apresenta-se como uma questão de saúde pública, sobretudo quando se trata das altas prevalências de violência contra a mulher. No entanto, em uma perspectiva relacional, considera-se que a violência possa ser cometida de diferentes formas e intensidades dentro de uma dinâmica conjugal, com ambos os cônjuges exercendo múltiplos papéis. A violência vivida nas relações íntimas pode estar em grande parte subnotificada e representa um estressor que pode potencializar diversos agravos à saúde mental. Neste sentido, as estratégias de coping representam um dos recursos utilizados para o manejo deste estressor conjugal. O presente estudo objetivou comparar as estratégias de coping utilizadas por mulheres que sofreram ou cometeram violência conjugal em um relacionamento heterossexual, em relação às que não experienciaram situações de violência. Trata-se de um estudo quantitativo, exploratório, comparativo e transversal, com 96 mulheres participantes acessadas por meio de um questionário online. Através de análises descritivas e Teste Mann-Whitney foi possível identificar índices elevados de violência sofrida e cometida, sobretudo agressões psicológicas, além de um uso significativamente maior da estratégia de coping de negação pelas participantes que cometeram e sofreram violência em relação às que não vivenciaram violência. Destaca-se a necessidade de potencializar a discussão e fomentar intervenções com este público, que levem em consideração às estratégias de enfrentamento utilizadas.
Convivência social e saúde mental: percepções de profissionais do sexo
Authors: Patricio Lopes Camila , Andrade Moreira Letícia , Cristina Pereira Schalcher Gabriela , Cristina Evangelista de Souza Larissa , Pereira Araújo Débora , Helena Vaz Malaquias Jéssica
Published: May 2023

A prostituição é uma das profissões mais antigas do mundo, mas ainda hoje é marginalizada. Tal fenômeno pode influenciar as redes de apoio dos profissionais, fragilizando e afetando sua saúde mental.  Dessa forma, o objetivo do estudo foi identificar as percepções sociais de profissionais do sexo e verificar a relação com a saúde mental através de entrevista, do Self Report Questionnaire e Ecomapa. Três das quatro participantes apresentaram sintomas suficientes para transtornos mentais comuns, a maioria dos componentes da rede de apoio foram considerados moderados e frágeis e os sentidos subjetivos das participantes indicaram sentimentos de desconfiança e desamparo.

Palavras-chave

Saúde mental; prostituição; rede de apoio
Psicodinâmica do Burnout em uma Professora de Ensino Fundamental e Médio
Authors: Sampaio Taynara , Silva Viviane , Medeiros Danuta , Salles Rodrigo Jorge
Published: May 2023

A presente pesquisa objetivou compreender a Síndrome de Burnout e seus desdobramentos numa professora do Ensino Fundamental e Médio, que apresenta essa condição. Trata-se de uma pesquisa clínica e qualitativa, que adotou o referencial teórico psicodinâmico, tendo seus dados coletados a partir de sessões de Psicodiagnóstico interventivo. Foram utilizados como instrumentos: questionário sociodemográfico e laboral; entrevista semiestruturada; Teste da casa-árvore-pessoa; Inventários de Depressão e Ansiedade de Beck; Teste de Apercepção Temática e Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo. Como resultado observou-se uma dinâmica psíquica caracterizada por um conflito entre Ego e seu ideal. Os mesmos conflitos também foram expressos no setting a partir da dinâmica transferencial, gerando um fenômeno aqui designado como Burnout transferencial.
Framing decision-making: the role of executive functions, cognitive bias and reward
Authors: Rovelli Katia , Allegretta Roberta Antonia
Published: May 2023

Decision-making is described as a cognitive and emotional process that allows an individual to select a certain action from a multitude of choices and possibilities. This process is commonly seen as a complicated interaction of high-level processes. It is engaged in a wide range of executive operations, concerning which it is possible to hypothesize how the decision-making is located in the continuum between hot and cool processes, involving a multifaced brain areas network. Besides the contextual influences in which decisions are taken this proposal highlights and investigates the relationship between decision-making and cognitive – attentional and perceptual – bias. Moreover, this article takes into exam the association between cost-benefit decisions underpinning executive performance and reward responsiveness. All these factors are considered highly relevant in explaining human behaviour.
Utilization of Spent Arabica Coffee Grounds as Raw Material for Activated Charcoal in Liquid Bath Soap Formulation
Authors:   Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia, Maysarah Hilda , Desiyana Lydia Septa ,   Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia, Nurzuhra Siti ,   Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia, Illian Didi Nurhadi ,   Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
Published: May 2023

Arabica coffee (Coffea arabica) is one of the most popular coffees among Acehnese, an ethnic group from Aceh, Indonesia. The amount of coffee consumed is directly proportional to the amount of coffee waste produced. Spent coffee grounds are the residue obtained during the brewing process. Spent coffee grounds can be utilized by converting them into active charcoal adsorbents. This study aimed to produce activated charcoal from spent arabica coffee grounds (SACG), to utilize it as an active ingredient in the liquid bath soap formulations, and to determine the best formula. The characterization of activated charcoal was conducted and compared to the Indonesian National Standard (SNI). The liquid bath soap contains activated charcoal from SACG was divided into five formulas with various concentrations of cocamidopropyl betaine (CAPB) and sodium lauryl sulphate (SLS) surfactants. Furthermore, the evaluation of liquid bath soap formula was performed. The characterization results showed that activated charcoal produced from SACG met the SNI requirements with a yield of 86.3%, volatile substance content of 10.67%, water content of 5.67%, ash content of 1.7%, pure carbon content of 81.96%, and iodium absorption of 1522.8 mg/g. The evaluation results revealed that liquid bath soap formula with activated charcoal from SACG containing a combination of 5% CAPB and 5% SLS (F5) was the best formula that met the requirements. SACG can be used as an excellent raw material for activated charcoal in liquid bath soap formulations.
Synthesis of Ferrous Fumarate from Indonesian Iron Sand and In Vivo Body Weight Gain Test in Rats
Authors:   Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia, Rukmana Taufiq Indra , Kurniadi Felicia Natalia ,   Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia, Harmita Harmita ,   Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia
Published: May 2023

Iron deficiency anemia (IDA) is a health problem in Indonesia. Prevention and treatment of IDA is carried out by giving fortified foods and oral iron therapy. Both can use ferrous fumarate which is made with reacting bivalent iron and disodium fumarate. Bivalent iron can be obtained from iron sand in Indonesia. This study aims to synthesize ferrous fumarate from Indonesian iron sand, which is from Malang, Sukabumi, and Cianjur area, and to determine its absorption through in vivo body weight gain test in male Wistar white rats (Rattus norvegicus). First, ferrous fumarate was synthesized through reaction of ferrous sulfate, which was made from Indonesian iron sand with the highest iron content, which was from Sukabumi area, and disodium fumarate. Second, in vivo body weight gain test was conducted to 3 rat groups (negative control, ferrous sulfate group, and ferrous fumarate group, respectively) and monitored for two weeks. The results showed that ferrous fumarate was successfully obtained as brownish red-orange fine powder with yield of 62.17 ± 1.66 %. In addition, the in vivo body weight test suggested that the rats from ferrous fumarate group showed similar weight gain (35.1%) compared to those from the ferrous sulfate group (30.6%), indicating a possibility of iron absorption from ferrous fumarate.
Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells
Authors: Povlsen Helle Rus , Bentzen Amalie Kai , Kadivar Mohammad , Jessen Leon Eyrich , Hadrup Sine Reker , Nielsen Morten
Published: May 2023

Novel single-cell-based technologies hold the promise of matching T cell receptor (TCR) sequences with their cognate peptide-MHC recognition motif in a high-throughput manner. Parallel capture of TCR transcripts and peptide-MHC is enabled through the use of reagents labeled with DNA barcodes. However, analysis and annotation of such single-cell sequencing (SCseq) data are challenged by dropout, random noise, and other technical artifacts that must be carefully handled in the downstream processing steps. We here propose a rational, data-driven method termed ITRAP (improved T cell Receptor Antigen Paring) to deal with these challenges, filtering away likely artifacts, and enable the generation of large sets of TCR-pMHC sequence data with a high degree of specificity and sensitivity, thus outputting the most likely pMHC target per T cell. We have validated this approach across 10 different virus-specific T cell responses in 16 healthy donors. Across these samples, we have identified up to 1494 high-confident TCR-pMHC pairs derived from 4135 single cells.
Direction of System Improvements through an Analysis of Performance and Foreign Cases Before and After Separate Ordering of the Fire-fighting System Installation Business Act
Authors: Choi Ji Eun , Kim Won Chang , Jeong Keesin , Lee Tae Gyu
Published: May 2023

In Korea, separate orders for the fire-fighting facility system installation business act have been in effect since September 2020. However, the current research on performance analyses and overseas system reviews remains inadequate for efficient settlements after the implementation of the separate order system for the fire-fighting system installation business act. In this study, we collected and visualized performance data before and after the implementation of separate orders for the fire-fighting system installation business act over the past four years and analyzed domestic and foreign legislative cases. As a result of the analysis, for the fire-fighting system installation business act, following the implementation of separate orders in Korea, the growth rate of construction amounts from 2020 to 2021 was found to be 44.7%. Moreover, a case of overseas separate orders was implemented to prevent the occurrence of unfair orders in separate orders according to the type and amount of construction. Therefore, in this study, a legal plan to improve the appropriateness and ratio of the amount according to the size of construction is devised.
CUIDADO DE ENFERMERÍA DEL PACIENTE CON TRASTORNO MENTAL EN ATENCIÓN DOMICILIARIA: REVISIÓN NARRATIVA
Authors:   Universidad Nacional de Colombia, Facultad de Enfermería. Bogotá, Colombia, Henao-Castaño Angela María , Aguilar Ortiz Laura Valentina ,   Universidad Nacional de Colombia, Facultad de Enfermería. Bogotá, Colombia, Rivera Romero Nathaly ,   Universidad Nacional de Colombia, Facultad de Enfermería. Bogotá, Colombia
Published: May 2023

INTRODUCCIÓN: El manejo integral del paciente con trastorno mental desde enfermería, incluye abordajes que son llevados a cabo en la atención domiciliaria permitiendo así desarrollar actividades de valoración, seguimiento y atención al paciente y su familia. MATERIALES Y MÉTODOS: Se realizó una búsqueda estratégica en Medline, Epistemonikos, Base JBI, Biblioteca Virtual en Salud, utilizando los términos “mental disease”, “mental illness”, “homecare”, “nursing”. La extracción y análisis de los datos se dio acorde a los planteamientos del JBI, RESULTADOS: Se identificaron 25 artículos que cumplían con los criterios de inclusión y se clasificaron en 4 temas: 1. La experiencia del cuidado en el domicilio del paciente con trastorno mental. 2. Adherencia a la medicación de pacientes con trastorno mental que reciben tratamiento en casa. 3. El adulto mayor con trastorno mental y 4. Estrategias tecnológicas para dar atención domiciliaria al paciente con trastorno mental. CONCLUSIONES: Para abordar integralmente el cuidado del paciente con trastorno mental en el domicilio se deben incluir intervenciones de cuidado soportadas en la evidencia que incluyan la instrucción al cuidador familiar, por lo que es central el rol de enfermería teniendo en cuenta la creciente demanda de intervenciones domiciliarias en psiquiatría basadas en la evidencia, teniendo en cuenta el impacto de la trastorno mental, así como con los desafíos sociales y económicos que conlleva el padecer una trastorno mental para el paciente y su familia.
A riqueza gerada por empresas sustentáveis: uma avaliação acionária
Authors: Dos Santos Renato Ribeiro , Medeiros Filho Marcos Antônio Carvalho
Published: May 2023

A sustentabilidade tem sido cada vez mais discutida pelos diversos setores da Sociedade. No presente estudo buscou-se verificar a influência das de práticas sustentáveis nas empresas de capital aberto, atualmente difundidas como ESG (Environmental, Social and Governance) para os respectivos acionistas. O objetivo da pesquisa foi avaliar se existe diferença relevante entre a riqueza gerada aos acionistas entre as empresas que praticam preceitos da ESG e aquelas que não o fazem e se a ESG contribui para tal diferença. Como contribuição teórica, o estudo aclara ainda mais a importância da ESG e sua utilização como proxy de análise. O trabalho contemplou amostra de 568 empresas brasileiras não pertencentes ao setor financeiro listadas na B3, para as quais foram trabalhadas regressões com dados em painel no período de 2010 a 2020. Como proxy de sustentabilidade foi considerada a participação das empresas no Pacto Global da ONU, especificamente a Agenda 2030, que compõe os 17 Objetivos de Desenvolvimento Sustentável (ODS) que buscam adoção de uma nova política global e o engajamento por parte das empresas no desenvolvimento sustentável. Os resultados não confirmaram significância da adesão aos ODS para o aumento no valor da riqueza gerada pelas empresas aos acionistas.
Eficiência administrativa dos municípios da região do Cariri Cearense no enfrentamento à pandemia de Covid-19
Authors: De Oliveira Antônio Rafael Valério , Chagas Milton Jarbas Rodrigues , Leite Ane Caroline Rodrigues , De Alencar Maria Raquel Xavier , Gomes Geysa Gabriela Pinheiro , Leal Paulo Henrique
Published: May 2023

A pandemia de COVID-19 ficou marcada mundialmente, dentre outros fatores, pelo aumento dos gastos com saúde. O Brasil foi demasiadamente impactado, pois mesmo antes da confirmação do primeiro caso da doença o país enfrentava graves problemas socioeconômicos e fiscais. Assim, um dos maiores desafios para o gestor público, em especial de saúde, consiste em buscar ganhos de eficiência, já que os recursos são escassos, notadamente em tempos de crises. Nesse sentido, o presente estudo tem como objetivo avaliar a eficiência administrativa dos municípios da região do cariri cearense no enfrentamento à pandemia  de  Covid-19, utilizando a Análise Envoltória de Dados (DEA), no modelo Retornos Constantes à Escala, proposto por Charnes, Cooper e Rhodes  (1978),  CCR,  e  no  modelo  Retornos  Variáveis  à Escala, proposto por Banker, Charnes e Cooper (1984) o BCC, com orientação para outputs, para o cálculo da eficiência dos 26 municípios. Com base no CCR, em que considera a proporcionalidade entre inputs e outputs, houve maior número DMU’s eficientes. Em relação ao BCC, o qual admite que a eficiência máxima varie em função da economia de escala. Na média, os municípios obtiveram melhores escores médios de eficiência pelo método BCC em comparação ao CCR. Houve aumento de gastos  com  saúde,  contudo  houve  desperdício  de 3,48% nas análises pelo método BCC. O número de notificados e de confirmados foram as variáveis que apresentaram o maior potencial de melhoria indicando a necessidade de redução do contágio. Além disso, o melhor nível de eficiência não necessariamente ocorre naqueles que tiveram maiores gastos.
A Rare Case of Hodgkin’s Lymphoma Presenting as Hypereosinophilia
Authors: Tongaonkar Arnav , Sonawale Archana , Prabhat Daksha , Waghmare Tejaswini , Mulkalwar Alhad , Patel Maurya
Published: May 2023

Although eosinophilia is a recognised associated feature of Hodgkin’s Lymphoma, hypereosinophilia is seldom the presenting feature in the patient. Here, the authors report an unusual case of a 21-year-old male patient who presented to the General Medicine outpatient department of the hospital with a history of multiple episodes of left-sided pleural effusion in addition to mediastinal and cervical lymphadenopathy. Baseline investigations revealed hypereosinophilia which was persistent despite Diethylcarbamazine (DEC) and steroid therapy. Computer Tomography (CT) guided biopsy of an anterior mediastinal mass, likely to be thymus, led to the diagnosis of Hodgkin's Lymphoma. The patient was transferred to the Haematology department where he was started on Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) chemotherapy regimen. Despite the fact that blood eosinophilia is an associated finding, it is rare for a patient to present with it. The authors also discuss the discrepancies related to the credibility of eosinophilia as a prognostic marker for Hodgkin’s disease.
FORMULATION, OPTIMISATION AND CHARACTERISATION OF ARTOCARPUS ALTILIS LOADED LIPOSOMES FOR ANTIDIABETIC ACTIVITY
Authors: Patil Archana M. , Kaliyaperumal Sarvanan , Patil Mrityunjaya B.
Published: May 2023

Background: Artocarpus altilis primarily comprises phenolic phytoconstituents such as flavonoids, arylbenzofurans, and stilbenoids. This plant has traditionally been known to have glycemic control properties. This study used a design expert approach to create and test Artocarpus altilis liposomes for antidiabetic activity. Methods: Design Expert 13 software developed and optimised the liposomal formulation. The optimised formulation was tested for antidiabetic properties in a Streptozotocin-nicotinamide-induced model for 28 days, followed by an oral glucose tolerance test. Biochemical parameters such as lipid profile and glycogen content were also measured at the end of the study. Results: The formation of Artocarpus altilis loaded liposomes was confirmed by SEM analysis and entrapment efficiency. Further pharmacology research revealed that Artocarpus altilis lowers blood glucose levels by sensitising insulin secretion, maintaining pancreatic beta cell mass, increasing glucose uptake in skeletal muscles, and regulating lipid profiles. Conclusion: The current study reflected the formulation of Artocarpus altilis loaded liposomes, its entrapment efficiency, stability study, and its antidiabetic evaluation based on in vivo results.
A CRITICAL REVIEW OF KANAKASAVAM
Authors: SG Vipin , Moharana Pradeep Kumar , PK Arathi
Published: May 2023

Kanakasavam is a polyherbal formulation with 14 ingredients used mainly in Swasa roga (respiratory diseases). In clinical practice, Kanakasavam is primarily used to treat respiratory diseases. It contains purified datura, which acts as a bronchodilator and has anti-inflammatory properties. It is also known to provide relief from an acute asthma attack and increases the airflow to the lungs by dilating and relaxing the bronchial passageways. Kanakasavam is also used for bronchitis, productive cough, chronic fever, haemorrhages, and lung injury. In addition, it is also beneficial in the treatment of the common cold, rhinitis and abnormal nasal discharges. This article is an attempt to analyse the formulation critically.
AYURVEDA CONCEPT OF VISHA: A REVIEW
Authors: Patil Vijay Vasantrao
Published: May 2023

Among the Ashtanga, Agada tantra (toxicology) stands separate in its concept, clinical approach, management and result. This is the only chapter that guides us in managing poison and poisoning conditions. As we all know, visha and visha chikitsa require a special mention in any medical system. The definition of Visha explained in Ayurveda is very close to the definition of poison in modern toxicology. Poison is a substance, which on ingestion, inhalation, absorption, application, injection or development within the body, in relatively small amounts, produces injury to the body by its chemical action. In Charaka Samhita, a study of visha gunas is necessary for its treatment. Since the basis of treatment is samanya-vishesha siddhanta, a drug or diet which is opposite in the properties of the disease should be used for its treatment.
IMPORTANCE OF MADHU IN AYURVEDA WITH SPECIAL REFERENCE TO HONEY: A REVIEW
Authors: Jayprakash Rathi Pritam
Published: May 2023

Madhu (Honey) is described in Ayurveda classical text in detail. It is necessary to study all this information comparatively and critically for the proper use of Honey. Synonyms, origin, type, properties and therapeutic as well as nutritional use of Honey are described in Ayurveda text in detail. Data is collected from Brihatrayi and other Ayurveda texts and presented in different tables. The explanation is given about various descriptions in different Ayurveda texts. The present study aims to review information about madhu in different Ayurveda texts and clarify its importance. After the study, it is clear that Honey is an important natural helpful substance for a healthy and diseased person.
Antimicrobial Efficiency of Commonly Used Disinfectants against Escherichia coli and Staphylococcus aureus
Authors: Frances Ejimofor, Chiamaka , Enoch Nwakoby, Nnamdi , Johnson Oledibe, Odira , Eziamaka Afam-Ezeaku, Chikaodili , Ann Mbaukwu, Onyinye
Published: May 2023

Three different types of disinfectants that are frequently employed in regular laboratories include ethanol, bleach, and phenols. This study used the agar hole diffusion method to examine the effectiveness of these three disinfectants against Staphylococcus aureus and Escherichia coli. Different bleach, ethanol, and phenolic concentrations were utilized. There were variations in the measured concentrations because the disinfectants' initial concentrations varied. The results after 24 hours of incubation at 37°C demonstrated that all the disinfectants in their concentrated forms prevented the development of the test organism. When different quantities of the inhibitors were used, their efficacy varied, and the width of the zone of inhibitions around each well was determined in millimeters.

The findings revealed that bleach had a stronger impact on Staphylococcus aureus than Escherichia coli, while ethanol showed the least susceptibility. Phenolics had the highest efficiency against both test species.
Characterization of Soil Toxicity in Kinkazi, Kitombe and Thiende Villages Affected by Oil Activities in Muanda and Potential Risk of Chemical Poisoning
Authors: Nsiala Gurvitch O. , Musibono Dieudonné E. , Kusonika Athanase N. , Tene Paul Martial T. , Ngelinkoto Patience M. , Biey Emmanuel M.
Published: May 2023

Aims: Discharges from oil exploitation contain very toxic and persistent organic and inorganic environmental pollutants. The present study aims to characterize the ecotoxicity of the soils of these three villages subjected to oil exploitation activities.

Study Design: This research consists of four parts, an introduction with literature review, a description of the study environment, the methods used and finally the results obtained.

Place and Duration of Study: In order to assess the impacts due to oil exploitation activities on the soil, a study was carried out on six soil samples taken from the villages Kinkazi, Kitombe and Thiende during the month of November 2022 in the territory of Muanda, Kongo Central, D.R. Congo.

Methodology: The soil samples were prepared in the laboratory according to standard procedures and a series of ecotoxicological tests were carried out with the analysis of some physico-chemical parameters using a Multiparameter. The data collected was processed and analysed with Excel 2010 software.

Results: The soils of the Kinkazi, Kitombe and Thiende villages, like dumping grounds for pollutants from oil activities, are and represent a risk of chemical poisoning for the population. The inhibitory dose (ID50) varies from 26.25 to 36 g/g indicating the toxicity of these soils to Hibiscus asper seeds and the germination index obtained gives an average of around 58.7%.

Conclusion: The ecotoxicological impact of oil activities on the soil represents a risk of chemical poisoning for the local population of Muanda given that these polluted soils are primarily used for agriculture and the species Hibiscus asper is one of the most popular species for crops market gardeners in the region.
Resource Efficiency and Economic Efficiency of Fish Farms in the Southeast of Côte d’Ivoire
Authors: Aboua Angui Christian Dorgelès Kevin
Published: May 2023

In Côte d'Ivoire, fish farming is seen as a supplement to fish production. A more efficient use of resources in the production process would assure sustainable fish production. Using a data envelopment analysis (DEA) model and cost-benefit analysis, this study examines the resource efficiency and economic efficiency of 32 fish farms in the southeast of Côte d'Ivoire. The results revealed that fish farmers showed low performance, with average technical efficiency scores of 0.738 (CRS) and 0.575 (SBM) and an average economic score of 0.553. The most technically and economically efficient fish farmers use industrial feed. The study found that fish farmers caused excesses in resource utilization, resulting in a shortfall in output utilizing DEA model scenarios. Scenario-3, based on the slack-based model, minimizing resources while maximizing output, revealed that reducing resource excesses would have increased output by 16.18%. Based on the cost-benefit analysis, fish farms produced a positive gross and net profit margin. According to the findings of this study, policymakers should play a significant role in improving fish farmers' access to quality feed and fingerlings. Furthermore, fish farmers must be trained in sustainable production and pond management procedures.
Weed Dynamics of Fodder Maize as Influenced by Different Herbicides
Authors: Raghuwanshi Monika , Jha A. K. , Verma Badal , Yadav Pushpendra Singh , Shrivastava Arti
Published: May 2023

The advancements in fodder maize cultivation practices over the past few years, has paved a change in the makeup of weed associations. This made it necessary to incorporate new, effective herbicides in the struggle against maize's primary weeds. Therefore, a field experiment was conducted at Research Farm, AICRP on Forage Crops, Department of Agronomy, JNKVV, Jabalpur (Madhya Pradesh) during Kharif season 2019 to devise an appropriate combination of herbicides required for the control of the complex weed diversity in fodder maize. The field experiment was laid out in randomized block design (RBD) with ten treatments (eight herbicidal combinations along with hand weeding twice at 20 and 40 DAS and a weedy check) and replicated thrice. Observations were recorded on the weed parameters and fodder yield of maize. Among monocots, the experimental field was infested with Echinochloa colona, Commelina communis and Digitaria sanguinalis. Phyllanthus niruri and Eclipta alba were dominated among dicots. Among all herbicidal treatment, topramezone 35 g/ha plus atrazine 250 g/ha was found to be significantly superior in reducing total weed density (9.49/m2,  11.50/m2) and total weed dry weight (6.43 g/m2, 7.91 g/m2) at 30 and 45 DAS, respectively and recorded the lowest weed index (1.82%). Also, the maximum green fodder yield (472.68 q/ha) was recorded in topramazone 35 g/ha + atrazine 250 g/ha compared to other treatments. Overall, this study indicated that the combination of topramazone 35 g/ha + atrazine 250 g/ha could be an alternative approach to hand weeding and alone herbicides in fodder maize.
Impact of Organic Nutrient Sources on Growth and Yield of Rice Varieties (Oryza sativa L.) and Yield Validation Using SPSS Model
Authors: Ganesh K. S. , Mehera Biswarup , Kumar Prateek
Published: May 2023

A field experiment was conducted during Kharif 2022 at Crop Research Farm, Department of Agronomy, SHUATS, Prayagraj (U.P) to determine the “Impact of organic nutrient sources on growth and yield of rice varities (Oryza sativa L.) and Yield Validation Using SPSS Model”. The experiment was laid out in Randomized Block Design comparising of 9 treatment which include 3 varieties RNR-15048,BPT-5204 AND NDR-359, 4 organic manures, Vermicompost 10(t/ha) and Panchagavya 6%+ Vermicompost 5(t/ha)+ Panchagavya 3%. Whose effect is observed in varieties rice. The treatmentsconsisted of organic nutrient sources and rice varities. [Panchagavya 6%+ Vermicompost 10t/ha, Panchagavya 3%+Vermicompost 5t/ha] and the rice varities [RNR-15048, BPT- 5204, NDR-359]. Whose effect is observed in paddy. The results observed that the treatment with application of NDR-359 + vermicompost 5t/ha + panchagavya 3% recorded higher plant height, number of tillers/hill, plant dry weight(g), CGR,RGR and yield parameter number of panicles/hill, number of grains/panicles, number of grains, test weight, grain yield, straw yield and harvest index. Treatment 9 has shown 44.62% increase over predicted yield whereas there was 28.89% increase in treatment 8 over predicted yield through SPSS model. From the basis of one year experimentation, it is concluded that Panchagavya 3% + Vermicompost 5(t/ha) was found more productive for the variety NDR-359.
The Moderating Role of Point-of-Purchase Price Information in Consumer Price Perception and Purchase Intention
Authors: Lii Yuan-Shuh , Ding May-Ching , Kuo Tzu Kuan
Published: May 2023

Aims: Advertised reference prices are one of the contextual prices that have attracted substantial interest. This research proposes the moderating effect of point-of-purchase price information related to product line and other brand prices on consumers’ price perception and purchase intention.

Methods: Using the literature review of reference prices as a method, it was found that contextual moderators that influence consumer perceptions of point-of-purchase price information were limited. Consequently, integrating the literature of advertised reference prices and the literature gap in this field leads to the proposition.

Conclusions: As a result, we propose that product-line prices and prices of other brands moderate the effect of an advertised reference price on the perceived value of consumers, the benefits of search, and the intention to purchase. Hence, the impact of advertised reference prices may be mitigated to a certain extent, which may reduce the deceptiveness of the advertised reference prices.
An Automatic Traffic Violation Ticketing System Using Radio Frequency Identification (RFID) Technology
Authors: Segun Shokenu Emmanuel , Oluwafunke Oke Alice , Iyase Ogbewey Leonard , Aransiola Elijah Aduragbemi , Adeagbo Monsuru Abolade , Abisola Bakare Alimat , Dada Babatunde Joshua
Published: May 2023

Travel convenience is impacted by a number of factors, including the condition of the road, traffic, length of trip, accidents, speed, etc. The daily increase in accident rates poses the biggest concern. These events not only result in fatalities but also increase the nation's financial losses. Traffic congestion is brought on by road users' lack of discipline and sentiments, which may result in traffic offenses. The goals of this research are to curb any traffic infractions as well as reduce corruption and nepotism on the road. This system was developed using an Atmega328 microcontroller, which instructs the system to identify any driver who violates a traffic light and send an SMS message to the violator and the road management of the violation and the location where it was done. This identification is done with the help of a radio frequency identification (RFID) reader, which gets the unique ID of the vehicle and sends back the information to the microcontroller, which now instructs the GSM module to send the SMS message.
Newer Possibilities for Proximal Box Elevation – Tooth Substrate and Comparison with Conventional Materials: An Ex-vivo Study
Authors: Kaur Rupam , Goyal Smiley , Sahiwal Harkiran , Grover Jasneel Singh , Bhullar Kanwalpreet Kaur , Handa Aashish
Published: May 2023

Background: Adhesive bonding in deep sub-gingival areas is a challenge due moist environment leading to poor marginal seal and microleakage in deep class II cavities. The deep margin elevation technique is advocated in such areas.

Aim: The aim of this study is to evaluate enamel, a natural substrate as an alternative material for deep margin elevation, and compare it with the resin-modified glass ionomer and composite material by evaluating microleakage at the tooth-restoration interface in Class II cavities.

Materials and Methods: For this study 21 patients having at least one tooth indicated for extraction and 7 patients having at least two teeth indicated for extraction were included.Class II cavities were prepared on the 28 teeth with proximal margins 1mm below the CEJ and were divided into 4 groups(n=7) Group 1: flowable composite was used for deep margin elevation(DME) up till 2mm above CEJ, Group 2: RMGIC was used for DMEup till 2 mm above CEJ, Group 3: enamel slab luted with RMGIC (for DME)up till 2mm above CEJ,enamel slab obtained from other seven teeth of same patient also indicated for extraction, Group 4(control): no intermediate material was used for margin elevation. Then the remaining part of the cavities were restored using the FILTEK P60. The prepared teeth were extracted after one week. The class II cavities were evaluated for microleakage using dye penetration method.

Results: RMGIC and enamel slab showed significantly less microleakage as compared to flowable composite and the control group. However there was insignificant difference between RMGIC and Enamel slab group. The control group exhibited highest microleakage as compared to all the other groups.

Conclusion: RMGIC and enamel slab exhibit least microleakage when used as materials for deep-margin elevation.
Why Fiscal Policies are Pro-cyclical in Economic and Monetary Community of Central Africa?
Authors: Simo Guy Noël Piam
Published: May 2023

The objective of this paper is to study empirically the cyclical behaviour of fiscal policies in CEMAC. According to the literature, fiscal policies are pro-cyclical in developing countries. Two main arguments are put forward: borrowing constraints during economic downturns; and irrational behaviour of governments, which do not save enough during booms because of political pressure groups. Over the period 1992 to 2012, using ordinary least and double least squares on panel data, our estimates show that fiscal policies are pro-cyclical in CEMAC and public investment spending is the most pro-cyclical. This is because their governments do not save enough when the terms of trade are favourable (boom periods), due to the fact that they rather take advantage of their access to external finance to increase public investment spending necessary for their development (rational behaviour).
Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5
Authors: Liu Zhenan , Yoon Joonho , Lee Eunyoung , Chang Audrey N. , Miller R. Tyler
Published: January 2025

Soluble, circulating Klotho (sKlotho) is essential for normal health and renal function. sKlotho is shed from the renal distal convoluted tubule (DCT), its primary source, via enzymatic cleavage. However, the physiologic mechanisms that control sKlotho production, trafficking, and shedding are not fully defined. We previously found that the G protein‐coupled calcium‐sensing receptor (CaSR) co‐localizes with membrane‐bound αKlotho and the disintegrin/metalloprotease ADAM10 in the DCT and controls sKlotho in response to CaSR ligands and pHo by activating ADAM10. Here, we advance understanding of this process by showing that tetraspanin 5 (Tspan5), a scaffolding and chaperone protein, contributes to the cell surface expression and specificity of a protein complex that includes Tspan5, ADAM10, Klotho, and CaSR. These results support a model of multiprotein complexes that confer signaling specificity beyond CaSR on G protein‐coupled processes.

Impact statement

Systemic circulating sKlotho is a determinant for normal physiology. Studies of knockout animals established its role as an anti‐aging protein. The regulatory mechanisms for Klotho production and secretion are largely unknown. We report that Tspan 5 contributes to CaSR‐ and ADAM10‐dependent Klotho shedding from the kidney, its primary source.