bluuebunny/crossref_metadata_2025 huggingface dataset:
A DIFERENÇA DO USO E NÃO USO DO LIVRO DIDÁTICO EM DUAS ESCOLAS NAS AULAS DE LÍNGUA INGLESA
Authors: Vieira Miliane Moreira Cardoso , Alves Miranda Reis Kaliny , De Melo Lima Neto Osmar , Pereira Gomes Davi , Da S. G. Toledo Sharon Elaine
Published: April 2020

O presente artigo busca comparar em duas escolas de Araguaína (TO) a questão do uso e não uso do livro didático de Língua Inglesa. As escolas que foram utilizadas como campus de pesquisa foram: CEM Castelo Branco e EE Vila Noval. Ao longo deste artigo explicaremos o porquê uma escola optou pela utilização do material e a outra instituição não. A pesquisa foi desenvolvida enquanto cursávamos o curso de Letras - Língua Inglesa e Literaturas da Universidade Federal do Tocantins e participávamos do Programa de Residência Pedagógica (PRP). Como embasamento teórico são utilizados documentos que trazem orientações sobre o ensino de Língua Inglesa no âmbito nacionais. Ao final dessa experiência no Programa Residência Pedagógica, tivemos a oportunidade de vivenciar a prática em duas escolas com realidades diferentes, nas quais adquirimos um grande aprendizado.
A IMPORTÂNCIA DO RESIDÊNCIA PEDAGÓGICA DA UFT/ARRAIAS NAS ESCOLAS DO CAMPO E A IMPLEMENTAÇÃO DA OFICINA DE FLAUTA-DOCE
Authors: De Jesus Soares Pereira Aparecida , Pereira da Silva Waldir , Firmino da Cunha Gomes Maristela , Sodré de Moura Karolyne
Published: April 2020

Este trabalho tem por objetivo apresentar o relato de experiência como residente do Programa Residência Pedagógica, vinculado ao Curso de Licenciatura em Educação do Campo Códigos e Linguagens Artes Visuais e Música da Universidade Federal do Tocantins - Campus de Arraias, tendo como campo de atuação, a Escola Estadual Girassol de Tempo Integral Agrícola David Aires França.
EXPERIÊNCIAS DA RESIDÊNCIA PEDAGÓGICA NA ESCOLA DE TEMPO INTEGRAL CEM-CASTELO BRANCO
Authors: Vieira Miliane Moreira Cardoso , Dos Santos Silva Paulo Ricardo , De Santana Leão Jacques Janynne , Da S. G. Toledo Sharon Elaine
Published: April 2020

O trabalho em tela aborda as experiências das regências aplicadas em uma escola de Ensino Médio, na cidade de Araguaína - TO, que ocorreram no segundo semestre do ano de 2019. Período no qual ocorreu a última fase de regências da Residência Pedagógica de Língua Inglesa. Nas experiências práticas procuramos manter o foco no ensino-aprendizado dos discentes, de forma que, ocorresse uma absorção eficaz dos conteúdos e o desenvolvimento de competências e habilidades de língua inglesa. De maneira que, os conteúdos enquadrassem-se com o contexto de vida dos alunos, partindo do local para o global. Ao fim da residência pedagógica, concluímos que enfrentamos situações complexas ao desenvolver as habilidades da docência e temos a satisfação de ter conseguido superar todos esses desafios e acumularmos experiências.
FORMAÇÃO DO ALUNO LEITOR ATRAVÉS DE AÇÕES EM CLUBE DE LEITURA NUMA ESCOLA DE ENSINO MÉDIO
Authors: SILVA-FONSECA VILMA NUNES DA SILVA FONSECA , Silva Fonseca Vilma Nunes da , Martins Andrade Silva Antonio
Published: April 2020

Com este artigo, objetivamos discutir a importância do Clube de Leitura “Leitores sem fronteiras” como ação didático-pedagógica de fomento à leitura e à promoção do letramento literário realizada numa escola de ensino médio, situada no município de Araguaína – Tocantins. A referida instituição de ensino esteve vinculada ao Programa Residência Pedagógica (2018-2020) através do Subprojeto de Língua Portuguesa, do Curso de Letras, da Universidade Federal do Tocantins – Câmpus de Araguaína. Nesta investigação qualitativa, analisamos relatos pessoais de 3 (três) alunos e da docente coordenadora das atividades do clube mencionado. Os resultados apontaram que, após a inclusão das atividades do clube no cotidiano escolar, os discentes demonstraram maior interesse pela leitura literária, havendo facilidade na aquisição das práticas de linguagem nas aulas de Língua Portuguesa/Literatura e melhor desempenho escolar ao final do processo avaliativo. Acrescentamos ainda, o registro do afloramento de jovens escritores que passaram não somente a consumir o texto literário, mas também a produzir poesia, conto e romance.            

Palavras-chave: Leitura literária; Formação do leitor; Ensino de Língua e Literatura.
RESIDÊNCIA PEDAGÓGICA NA UFT/ARRAIAS: OFICINA DE CONFECÇÃO DE INSTRUMENTOS MUSICAIS EM UMA ESCOLA DO CAMPO
Authors: De Jesus Soares Pereira Aparecida , Lúcia dos Santos Almeida Ribeiro Vera , Romualdo Bispo Dayane , Domingos Correia Rosinilton , Reges da Cunha Sulene
Published: April 2020

O intuito deste trabalho é demonstrar a importância do Programa Residência Pedagógica (PRP) da Universidade Federal do Tocantins em Arraias na inter-relação e inserção do ensino musical no âmbito educacional de uma Escola de Educação Básica do campo por meio do PRP, destacando assim aspectos positivos e negativos enfrentados em efetivação. Desse modo, o subprojeto RP “O ensino de música nas escolas do campo” do Curso Licenciatura em Educação do Campo, Códigos e Linguagens: Artes Visuais e Música – Campus de Arraias proporciona ao residente o aperfeiçoamento da prática docente, contribuindo para a formação profissional na área de Artes Visuais e Música, e consequentemente no desenvolvimento de habilidades práticas, especificamente para o ensino de música nas escolas de educação básica campesina.
EPIDEMIOLOGIA DO SURTO DE DOENÇA POR CORONAVÍRUS (COVID-19)
Authors: Gonçalves Ferreira Netto Raimundo , Do Nascimento Corrêa José Wilson
Published: April 2020

Desde os relatos vindos da China de pneumonia de origem não conhecida, passando pela identificação do novo coronavírus SARS-Cov-2 como agente causador da doença COVID-19, o mundo enfrenta grandes desafios para conter seu avanço e elucidar seu tratamento. O vírus é capaz de ser transmitido de pessoa a pessoa por gotículas originárias de nariz e boca de pacientes infectados ou por contato com superfícies contaminadas. Os sintomas da infecção podem evoluir de tosse, febre e congestão nasal à pneumonia grave. Parcela de indivíduos infectados pode permanecer assintomática e contribuir com propagação do vírus, especialmente para idosos e indivíduos com outras comorbidades que são mais susceptíveis às manifestações graves da doença. O número de novos casos confirmados está em uma crescente, o que reforça a necessidade de manutenção de medidas sanitárias. As projeções para novos casos e, em especial, para o número de mortes causadas por formas graves de COVID-19 para o Brasil são preocupantes e variam de 44.000 a aproximadamente 1.100.000 mil mortes, a depender das medidas tomadas. Este artigo revisa este cenário e relata as estratégias recomendadas pela OMS aos países. Particularmente, discute a cronologia e o cenário atual da COVID-19 no Brasil.

Palavras-chave: Epidemiologia, COVID-19, SARS-Cov-2
Non-Coding RNAs and Innovative Therapeutic Strategies to Target the 5’UTR of SARS-CoV-2
Authors: Baldassarre Antonella , Paolini Alessandro , Bruno Stefania Paola , Felli Cristina , Tozzi Alberto Eugenio , Masotti Andrea
Published: April 2020

After the increasing number of SARS-CoV-2 infections all over the world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies to treat this viral infection. The SARS-CoV infection that occurred in 2002, MERS and other more common infectious diseases such as HCV, led to the discovery of many RNA-based drugs. Among them, siRNAs and antisense LNAs have been demonstrated to have effective antiviral effects both in animal models and humans. Owing to the high genomic homology of SARS-CoV-2 and SARS-CoV (80-82%) the use of these molecules could be employed successfully also to target this emerging coronavirus. Trying to translate this approach to treat COVID-19, we analyzed the common structural features of viral 5’UTR regions that can be targeted by non-coding RNAs and we also identified miRNAs binding sites suitable for designing RNA-based drugs to be employed successfully against SARS-CoV-2.
Fear-avoidance beliefs are associated with exercise adherence: Secondary analysis of a randomised controlled trial (RCT) among female healthcare workers with recurrent low back pain
Authors: Taulaniemi Annika , Kankaanpää Markku , Rinne Marjo , Tokola Kari , Parkkari Jari , Suni Jaana Helena
Published: April 2020

Background: Exercise is recommended for the treatment and management of low back pain (LBP) and the prevention of chronicity. Exercise adherence has been only modest in intervention studies among people with musculoskeletal pain. Fear-avoidance beliefs (FABs) are known to affect exercise adherence.The purpose was twofold: to examine which bio-psycho-social factors contributed to exercise adherence during a 6-month neuromuscular exercise intervention among female healthcare workers with recurrent LBP, and to investigate how exercising affects FABs at 6 and 12 months’ follow-up. Methods: Some 219 healthcare workers aged 30–55 years with mild-to-moderate re-current non-specific LBP were originally allocated into: 1) exercise, 2) counselling, 3) combined exercise and counselling, and 4) control groups. In the present secondary analysis, groups 1 and 3 (exercise only and exercise+counselling) were merged to be exercisers and groups 2 and 4 were merged to be non-exercisers. Baseline variables of the exercise compliers (≥24 times over 24 weeks; n=58) were compared to those of the non-compliers (<1 time/week, 0–23 times; n=52). The effects of the exercise programme on FABs were analysed by a generalised linear mixed model according to the intention-to-treat principle (exercisers; n= 110 vs non-exercisers; n=109) at three measurement points (baseline, 6, and 12 months). A per-protocol analysis compared the more exercised to the less exercised and non-exercisers. Results: A low education level (p=0.026), shift work (p=0.023), low aerobic (p=0.048) and musculoskeletal (p=0.043) fitness, and high baseline physical activity-related FABs (p=0.019) were related to low exercise adherence. The exercise programme reduced levels of both physical activity- and work-related FABs, and there was a dose response: FABs reduced more in persons who exercised ≥24 times compared to those who exercised 0-23 times.Conclusion: Healthcare workers who had lower education and fitness levels, worked shifts, and had high physical activity-related FABs had a lower adherence to the 6-month neuromuscular exercise programme. Exercising with good adherence reduced levels of FABs, which have been shown to be linked with prolonged LBP. Motivational strategies should be targeted at persons with low education and fitness levels and high FABs in order to achieve better exercise adherence.
The exopolysaccharide–eDNA interaction modulates 3D architecture of Bacillus subtilis biofilm
Authors: Peng Na , Cai Peng , Mortimer Monika , Wu Yichao , Gao Chunhui , Huang Qiaoyun
Published: April 2020

Background Bacterial biofilms are a surface-adherent microbial community in which individual cells are surrounded by a self-produced extracellular matrix of polysaccharide, extracellular DNA (eDNA) and proteins. Interactions among matrix components within the biofilms are responsible for creating an adaptable structure during biofilm development. However, it is unclear how the interaction among matrix components contributes to the construction of the three-dimensional (3D) biofilm architecture. Results DNase I treatment could significantly inhibit B. subtilis biofilm formation in early phases. Confocal laser scanning microscopy (CLSM) and image analysis revealed that eDNA was cooperative with exopolysaccharide (EPS) in early stages of B. subtilis biofilm development, while EPS played a major structural role in the later stages. In addition, deletion of EPS production gene epsG in B. subtilis SBE1 resulted in loss of the interaction between EPS and eDNA, and reduction of biofilm biomass in pellicles at air-liquid interface. The physical interaction between these two essential biofilm matrix components was confirmed by isothermal titration calorimetry (ITC). Conclusions The biofilm 3D structures become interconnected through surrounding eDNA and EPS. eDNA interacts with EPS in the early phases of biofilm development, while EPS mainly participates in the maturation of biofilm. The findings of this study provide better understanding of the role of interaction between eDNA and EPS in shaping the biofilm 3D matrix structure and biofilm formation.
The effect of transversus abdominis plane block on the chronic pain after colorectal surgery: a retrospective cohort study
Authors: Pan Zi-Ye , Hu Zhong-Hua , Zhang Fan , Xie Wen-Xiu , Tang Yong-Zhong , Liao Qin
Published: April 2020

Background: Chronic postsurgical pain (CPSP) is common and would reduce the quality of life of patients. Transversus abdominal plane (TAP) block has been widely used in lower abdominal surgery and many researches demonstrated that it could improve acute postsurgical pain. We aim to determine whether TAP block could improve chronic postoperative pain at 3 months and 6 months after colorectal surgery. Methods: A total of 307 patients received selective colorectal surgery under general anesthesia between January, 2015 and January, 2019 in a single university hospital were included: 128 patients received TAP block combined with patient-controlled intravenous analgesia (PCIA) for postsurgical analgesia (group TP) and 179 only administrated with PCIA (group P). Main outcome was the NRS score of pain at 24 hours, 48 hours, 3 months and 6 months after colorectal surgery. The data was analyzed by two-way repeated measures anova and the chi-square test. Results: T he NRS score at rest and during movement was decreased significantly at 24 hours after surgery ( rest NRS 1.07±1.34 vs 1.65±1.67, movement NRS 3.00±1.45 vs 3.65±1.89; all P =0.003) in group TP than those of group P. There was no significant difference of NRS score at 48 hours after surgery ( P >0.05). At 3 months after surgery, the NRS score during movement was also lower in group TP than that in group P (0.59±1.23 vs 0.92±1.65, P =0.045). There was no significant difference of NRS score at 6 months after surgery ( P >0.05). The prevalence of CPSP was 19.5% (25/128) in group TP and 20.7% (37/179) in group P at 3 months after surgery. 13.2% (17/128) of patients suffered from CPSP in group TP and 13.9% (25/179) in group P at 6 months after surgery. Both at 3 months and 6 months after surgery, there was no statistical difference of the prevalence of CPSP between the two groups (all P >0.05) . Conclusions: TAP block reduced NRS during movement at 3 months after surgery but did not reduce the incidence of CPSP at 3 months and 6 months after selective colorectal surgery.
Axitinib as a third or further line of treatment in renal cancer. A single institution experience
Authors: Tsironis Giorgos , Liontos Michalis , KYRIAZOGLOU ANASTASIOS , Koutsoukos Konstantinos , Tsiara Anna , Kaparelou Maria , Zakopoulou Roubini , Cohen Abis , Skafida Efi , Fontara Sofia , Zagouri Flora , Bamias Aristotelis , Dimopoulos Meletios Athanasios
Published: April 2020

Background: Kidney cancer is a lethal neoplasm that affects several thousands of people every year. Renal cell carcinoma (RCC) is the most common histologic type. Recent developments in the therapeutic approach include antiangiogenic targeted approaches and Immunotherapy. Thus, the therapeutic algorithm of RCC patients and the survival outcomes have changed dramatically. Methods: Herein we present a retrospective study of the patients treated in our Department with an antiangiogenic agent -Axitinib, a tyrosine kinase inhibitor- as a third or further line treatment. Statistical analysis was performed with SPSS, including the available clinicopathological data of the patients included. Results: Axitinib was found to be active in patients who received this treatment beyond second line. The toxicity profile of this regimen did not reveal any unknown adverse events. Conclusions: Our real world data reflect that axitinib is a safe and effective option, even beyond the second line.
Dairy Cow Culling - Reasons And Risk Factors
Authors: Rilanto Triin , Reimus Kaari , Orro Toomas , Emanuelson Ulf , Viltrop Arvo , Mõtus Kerli
Published: April 2020

Background Culling is a major cost for dairy farms but also an essential part in managing herd productivity. The study aimed to identify the culling rates of Estonian dairy cows, identify the farmers´ stated reasons and risk factors for culling. This observational study used registry data of all cows from herds with ≥20 cow-years in 2013-2015. Cow lactation-level analyses included data of 86,373 primiparous cows from 409 herds and 177,561 lactations of 109,295 multiparous cows from 410 herds. Weibull proportional hazard regression models were used to identify risk factors for culling due to slaughter or death.Results The overall culling rate of Estonian dairy cows was 26.24 (95% CI 26.02; 26.46) per 100 cow-years. The most common farmers´ stated reasons for culling were feet/claw disorders (26.4%), udder disorders (22.6%), metabolic and digestive disorders (18.1%) and fertility problems (12.5%). Animal-level risk factors for culling were Holstein breed, older parity, lower milk yield breeding value, older age at first calving, longer previous calving interval, having assisted calving, stillbirth and birth of twins/triplets. Lower milk yield, somatic cell count over 200,000 cells/ml and fat/protein ratio over 1.5 at first test-milking after calving were associated with greater culling hazard during the lactation. Cows from larger herds, herds with decreasing size and higher milk yields had higher culling probability.Conclusions This study emphasises the need for improved management of hoof health and prevention of mastitis and metabolic diseases. It is essential to ensure easy calving and good health of cows around calving in order to lower the culling hazard.
Effectiveness of circular external fixator in periprosthetic fractures around the knee
Authors: Nozaka Koji , Miyakoshi Naohisa , Hongo Michio , Kasukawa Yuji , Saito Hidetomo , Kijima Hiroaki , Tsuchie Hiroyuki , Mita Motoki , Shimada Yoichi
Published: April 2020

Background: The incidence of periprosthetic fractures after total joint arthroplasty (TJA) is rising due to an increasing number of TJAs performed annually and the growing elderly population. In many elderly patients with periprosthetic fractures, the bone strength is lowered due to the deterioration of bone quality and a decrease in bone quantity; rigid fixation of the fracture is difficult. It is a challenging operation for orthopedic surgeons. The usefulness of circular external fixation for periprosthetic fractures has been reported in several case studies. The aim of this study was to investigate the rate of union and complications associated with circular external fixation in periprosthetic fractures around the knee. Methods: We included 19 patients with periprosthetic femur and tibial fractures who underwent osteosynthesis using a circular external fixator and had at least 2 years of follow-up. All patients had comorbidities and high risks associated with anesthesia. Tourniquets were not used in any of the patients. There were no cases in which the skin incision was placed, and the closed reduction technique was used in all cases. Results: A 100% union rate was achieved with no serious complications. All fractures healed after a mean time of 14.3±5.2 weeks (range, 8-38 weeks). The walking ability was the same level as before the injury in 13 cases. Discussion: There are many comorbidities associated with periprosthetic fractures in elderly patients. Double-plate or revision surgery were largely invasive and had high risks associated with anesthesia. Circular external fixation is a feasible and effective treatment option because it provides stable fixation, prompt postoperative mobilization, and has no major complications, especially in elderly patients who are treated for periprosthetic fractures Conclusion: Circular external fixation is a safe and reliable method for periprosthetic fractures around the knee in elderly patients. Level of evidence: Level IV, retrospective case series
Effect of toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial
Authors: Jung Su-Jin , Kim Woo-Lim , Park Byung-Hyun , Lee Seung-Ok , Chae Soowan
Published: April 2020

Background: Detox diet are known as a popular dieting strategies that helps toxins elimination and weight manage but there is very little clinical evidence. The Wellnessup diet (WD) used in the present study designed as a healthy meals based on organic plant based diets including various vegetables, fruits, whole grains, nuts and phytonutrients. Methods: To evaluate the effects of 4 week intake of the WD on toxic trace element detoxification, body fat reduction, and safety parameters. Forty-five women with body mass index (BMI) of 23.5-30 kg/m2 were recruited. Thirty of them were assigned 1:1 to the test group (WD, 15 subjects) and control group 1 (calorie-restricted diet, CRD, 15 subjects) in a single blind and randomized, and the remaining 15 subjects were assigned to control group 2 (maintaining regular diet, MRD). The primary outcome were toxic trace element levels in hair (29 types of heavy metals), and the secondary outcomes were changes in anthropometric and urinary organic acids. Results: The levels of four toxic trace elements in hair decreased in the WD group after the diet compared to before the diet. Ni, Rh, Sn, and Ga were significantly lower in the WD group than in the CRD or MRD group (p<0.05). At the end of the trial, both WD and CRD groups had lower BMI, Waist Circumference(WC), Hip Circumference(HC) and WHR compared to the baseline values (p<0.05). Compared to the WD group, the CRD group had a greater mean change (p<0.05) from the baseline for weight loss (-3.22±0.48kg vs -1.88±0.95kg vs) and fat free mass (-2.08 kg vs -1.09 kg). The weight, BMI, body fat mass, fat free mass, WC, and HC of the CRD group were significantly decreased compared to the MRD (p<0.05). No significant changes in any safety parameter were observed. Conclusions: Use of WD might have several beneficial effects and safety such as body fat reduction and improving some the element detoxification through caloric restriction but did not reducing body fat mass more than calorie-restricted diet.
Quality of life in patients with psoriasis seen in the Department of Dermatology, Antananarivo Madagascar.
Authors: Sendrasoa Fandresena Arilala , Volatantely Ratovonjanahary , Harinjara Razanakoto Naina , Onivola Raharolahy , Fifaliana Rakotoarisaona Mendrika , Avotriniaina Rakotonaivo Niriantsoa , Malalaniaina Andrianarison , Moril Sata , Mamisoa Ranaivo Irina , Soavina Ramarozatovo Lala , Fahafahantsoa Rapelanoro Rabenja
Published: April 2020

BACKGROUND: Psoriasis is a chronic, inflammatory and multifactorial dermatosis that impairs quality of life (QoL). Health-related QoL has become an important element in medical decision making along with the effectiveness and the harmlessness of the treatments.OBJECTIVE: To assess the impact of psoriasis in the QoL of patients with psoriasis by using the DLQI scales.METHODS: A cross-sectional study, during ten months, was conducted in the Department of Dermatology of the University Hospital Joseph Raseta Befelatanana Antananarivo Madagascar including patients more than 15 years-old with moderate to severe psoriasis. The severity of psoriasis was assessed using the “Psoriasis Area and Severity Index (PASI)”. QoL of patients with psoriasis was evaluated by using the DLQI scales.RESULTS: 80 patients were included, their mean age was 36.52 years and the male to female was 1.5:1. The mean DLQI score was 13.85. Symptoms, feelings and psychic were the most altered dimensions. QoL was impaired in young patients, single, having medium level education. Even though patients with disease duration more than 5 years had higher DLQI score than other patients, the difference was not statistically significant (p=0.36). Furthermore, clinical presentation of psoriasis didn’t influence patient’s QoL (p=0.73). Patients with nail involvement had QoL impaired but the difference with another localization was not statistically significant (p=0.2).The quality of life was influenced by body area involved. The higher the body surface area involved, the more QoL is impaired (p=0.002). Furthermore, the higher the PASI, the more QoL is altered (p=0.002).CONCLUSION: Psoriasis has a negative impact in the quality of life in Malagasy patients with psoriasis, especially in younger and single patients. Worse quality of life is correlated to severity of psoriasis.
Morphological parameters of fourth lumbar spinous process palpation: a three-dimensional reconstruction of computed tomography
Authors: Feng Qi , Zhang Lei , Zhang Mengyao , Wen Youliang , Zhang Ping , Wang Yi , Zeng Yan , Wang Junqiu
Published: April 2020

Background: The localization of lumbar fourth spinous process (L4-SP) is an important anatomical landmark, and identifying its accurate position is essential for the diagnosis and treatment of waist diseases.Methods: Five hundred participants were scanned with positive and lateral computed tomography (CT), which aimed to clarify anatomic characteristics of L4-SP. Anatomical parameters of the surface localization of L4-SP were measured and recorded through a three-dimensional (3D) reconstruction.Results: Five hundred participates were classified into three types according to the position of BC with the iliac spine. There are just 266 that the line between the highest point of the iliac spine on both sides located on L4-SP (type Ⅰ, 53.20%), 16 above L4-SP (type Ⅱ, 3.20%), and 218 below L4-SP (type Ⅲ, 43.60%). BC in type Ⅰ (15.92±1.30 mm) is longer than type Ⅲ (15.56±1.32 mm). While the angle combined with AB and BC are different in the three groups, the angle in type Ⅰ (173.00±4.83°) is larger than that in type Ⅱ (164.69±5.50°) and type Ⅲ (159.45±8.39°). Other measurements were not found any significant differences between above.Conclusion: The traditional palpation for L4-SP is not absolutely exact. The accuracy rate is only 53.20%, and the errors may cause serious consequences.
Curative Effect and Safety of Tolvaptan Combined with Traditional Diuretics in Treatment of Patients with Cirrhotic Ascites and Relevant Research on its Dose: A Systematic Review with Meta-Analysis of Randomized Controlled Trials
Authors: Li Xin , Liu Shidong , Zhang Hui , Liang Fuxiang , Miao Long , Xu Hao , Zhao Zhenjie , Zhou Wence
Published: April 2020

Background: Tolvaptan is a receptor antagonist of highly selective vasopressin V2, and it can promote excretion of water without electrolyte. Aims: To evaluated curative effect and safety of Tolvaptan in treatment of cirrhotic ascites, and its relationship with drug dose. Methods: Computer retrieval of PubMed, EMbase and The Cochrane Library was carried out to search the clinical trials of cirrhotic ascites treatment by Tolvaptan. The time limit of retrieval is from the database setup to May 31, 2019. 2 researchers independently screened studies, extracted the data and crosschecked. RevMan 5.3 software was used for Meta-analysis.Results: Finally, 6 articles and 848 patients were included in the study. Meta-analysis indicates that after the intervention for 7 days, serum sodium ion concentration of the combined diuretic group obviously increased, compared with the traditional diuretic group (WMD=2.92mmol/L, 95%CI [2.15, 3.70], P<0.001). In addition, Tolvaptan also can decrease patients’ ascites amount through increasing liquid discharge. However, the drug dose has no obvious correlation with the reduction degree of ascites amount. The rise of blood uric acid is the major adverse event in the treatment of cirrhotic ascites patients by Tolvaptan (OR=6.01, 95%CI [1.11, 32.56], P=0.04). When the dose of Tolvaptan rose to 15mg or 30mg, the total incidence of adverse events was obviously higher than it of traditional diuretic group.Conclusion: Tolvaptan combined with traditional diuretics has good curative effect for the patients with cirrhotic ascites. As its adverse reactions, the recommended dose of Tolvaptan is 7.5mg in the combined therapy.
Acute Superior Mesenteric Artery Embolism treated with Percutaneous Mechanical Thrombectomy: Preliminary application and Experience
Authors: Xu Qiyang , Wang Yi , Wang Di , Hu Songjie , Xu Bin , Yang Leibo , Yu Zuanbiao , Lang Dehai
Published: April 2020

Background: Acute superior mesenteric artery embolism is a life-threatening disease and the prognosis is very poor. Few reports have described the application of Percutaneous Mechanical Thrombectomy in Acute superior mesenteric artery embolism. In the article, we show a series of cases treated with Percutaneous Mechanical Thrombectomy and share our experience. Methods: Review and analyze seven patients with acute superior mesenteric artery embolism treated by Angiojet Ultra thrombectomy system in our institution. Based on the literature, we summarize the diagnosis, treatment and surgical experience of acute superior mesenteric artery embolism. Results: Percutaneous Mechanical Thrombectomy were achieved successfully in all the patients without surgical complication occurred. Five patients’ symptoms relieved significantly and smoothly discharged from the hospital. Two patients still complained of abdominal pain after operation. One patient underwent surgical laparotomy and intestinal resection and the other one abandoned surgical treatment. During the first six months of follow-up, six patients were free of any clinical symptoms or signs and one patient who refused laparotomy died two days later with septic shock. Conclusion: Percutaneous Mechanical Thrombectomy by Angiojet Ultra thrombectomy system is a safe, effective and minimally invasive method in the initial stage of acute superior mesenteric artery embolism. We believe Percutaneous Mechanical Thrombectomy could be a promising alternative in selected cases. Furthermore, large sample data and long term follow-up are needed to verify its effect.
It Was Like Nobody Cared About What I said? Iranian women committed self- immolation: A Qualitative Study
Authors: Aghakhani Nader , Lopez Violeta , Parizad Naser , Baghaei Rahim
Published: April 2020

Background Suicide is a deliberate method initiated with a complete awareness to die. Survivors of self-immolation, a violent suicide method, require long-term emotional and social rehabilitation. This study aimed to explore the influencing factors and experiences of self-immolation in Iranian married women.Methods This study was conducted using a qualitative method. Conventional content analysis was used to analyze data. We purposefully approached 16 married Iranian women [aged 16 to 40 years] in burn centers in Urmia city, located in northwest Iran. Data were collected using an open-ended in-depth face to face interviews at a time and convenient to them.Results Five main themes emerged from data analysis: “Overwhelming family situation and rules”, “Feelings of disappointment, anger, deprivation, depression, shame and grief”, “Choosing self-immolation as a final solution to get rid of the sufferings”, “Accepting own mistake”, and “seeking family support to start a new life. The study highlighted the need for health professionals to focus on the survivors’ and family members’ mental turmoil to help and encourage them to continue a normal life”.Conclusions The qualitative findings suggest that to reduce this social impact, comprehensive supportive programs based on sufferers’ needs to promote their quality of life in all its complexity are recommended.
Is totally laparoscopic gastrectomy without prophylactic drains feasible for patients with distal gastric cancer? The experience of China National Cancer Center
Authors: liu hao , Jin Peng , Xu Quan , Xie Yibin , Ma Fuhai , Ma Shuai , Tian Yantao
Published: April 2020

Background

Prophylactic drains have been used to remove intraperitoneal collections and to detect complications early in open surgery. In the last decades, Gastric cancer minimally invasive surgery has been widely carried out throughout the world. However, little has been reported on routine prophylactic abdominal drainage after totally laparoscopic distal gastrectomy. To evaluate the feasibility of without prophylactic drains in totally laparoscopic distal gastrectomy in selective patients.
Methods

Data of distal gastric cancer patients underwent totally laparoscopic distal gastrectomy with and without prophylactic drainage at China National Cancer Center/Cancer Hospital from February 2018 to August 2019 were reviewed. The outcomes of patients with and without a prophylactic drainage were compared.
Results

A total of 420 patients who underwent surgery for gastric cancer were identified; of these, 88 patients who received totally lapaoscopic distal gastrectomy were included. The incidence of concurrent illness was higher in the drain group, (48.8% vs. 27.7%, p = 0.041). The overall postoperative complication rate was 19.5% in the drain group (n = 47), and 10.6% in the no-drain group (n = 41), there were no significant differences between two groups (p > 0.05). The need for percutaneous catheter drainage (PCD) was also not significantly different between groups (9.8% vs. 6.4%, p = 0.700). However, patients with larger BMI (≥ 29) are prone to postoperative complications (p = 0.042). In addition, more operating time cost in the drain group than in the no-drain group (188.10 ± 38.89 min vs. 164.30 ± 36.97 min, p < 0.05). The number of days after surgery until the initiation of soft diet (5.34 ± 2.27 days vs. 4.17 ± 2.13 days, p < 0.05) and first flatus (4.29 ± 1.45 days vs. 3.55 ± 1.83 days, p = 0.041) were greater in the drain group.
Conclusions

Without prophylactic drainage may reduce surgery time and result in faster recovery. Routine prophylactic drains are not necessary in selective patients. A prophylactic drain may be useful in patients at higher risk.
Comparison of clinical outcomes with proximal femoral nail anti-rotation versus InterTAN nail for intertrochanteric femoral fractures: A meta-analysis
Authors: Liu Wei , Ji Guangrong , Liu Jie
Published: April 2020

Objective: To access the efficacy and safety of proximal femoral nail anti-rotation (PFNA) and InterTAN nail for intertrochanteric femoral fractures.Methods: According to the Cochrane systemic analysis method, randomized control trials (RCTs) and retrospective comparative observational studies which were related to the comparison of PFNA and InterTAN nail in the treatment of the elderly with intertrochanteric fractures were retrieved. Data were independently extracted from the included studies by two reviewers and analyzed using RevMan 5.3 , and the quality of the studies was assessed.Results: Two RCTs and seven observational studies were recruited, which consisted of 681 patients with PFNA and 651 patients with InterTAN nail. The meta-analyses showed no significant differences between the two approaches on Harris Hip Score, operation time, blood loss, time to union, mean hospital stay, union problems, intraoperative complications, hematoma, infection, other complication in both RCTs and observational studies. In terms of other outcomes, for the RCTs, results showed that there were shorter tip–apex distance, reduced pain at thigh or hip in InterTAN nail than in PFNA; however, InterTAN nail was not superior to PFNA in cutout, reoperation, and femoral shaft fracture; for observational studies, the risk of the screw migration (RR=5.13, 95%CI: [1.33,19.75], P=0.02), cutout (RR=3.26, 95%CI: [1.64,6.47], P=0.0008), the varus collapse of the femoral head (RR=7.19, 95%CI: [2.18,23.76], P=0.001), femoral shaft fracture (RR=5.73, 95%CI: [2.24,14.65], P=0.0003) treated by InterTAN nail were significantly decreased, compared with those by PFNA; however, no significant differences was observed in the aspects of tip–apex distance and pain at thigh or hip between these two groups.Conclusion: Analysis of a large number of relevant clinical indicators available shows that InterTAN nail has better clinical manifestation than PFNA in treating unstable femoral intertrochanteric fractures.
Health Technology Assessment and priority setting for Universal Health Coverage: A qualitative study of stakeholders capacity, needs, policy areas of demand and perspectives in Nigeria
Authors: Uzochukwu Benjamin Sunday , Okeke Chinyere Cecilia , O’Brien Niki , Ruiz Francis , Sombie Issiaka , Hollingworth Samantha
Published: April 2020

Introduction Health technology assessment (HTA) is an effective tool to support priority setting and generate evidence for decision making especially en route to achieving universal health coverage (UHC). We assessed the capacity needs, policy areas of demand, and perspectives of key stakeholders for evidence-informed decision making in Nigeria where HTA is still new. Methods We surveyed 31 participants including decision makers, policy makers, academic researchers, civil society organizations, community-based organizations, development partners, health professional organizations. We revised an existing survey to examine the need, policy areas of demand, and perspectives of stakeholders on HTA. We then analyzed responses and explored key themes. Results Most respondents were associated with organizations that generated or facilitated health services research. Research institutes highlighted their ability to provide expertise and skills for HTA research but some respondents noted a lack of human capacity for HTA. HTA was considered an important and valuable priority-setting tool with a key role in the design of health benefits packages, clinical guideline development, and service improvement. Public health programs, medicines and vaccineswere the three main technology types that would especially benefit from the application of HTA. The perceived availability and accessibility of suitable local data to support HTA varied widely but was mostly considered inadequate and limited. Respondents needed evidence on health system financing, health service provision, burden of disease and noted a need for training support in research methodology, HTA and data management Conclusion The use of HTA by policymakers and communities in Nigeria is very limited mainly due to inadequate and insufficient capacity to produce and use HTA. Developing sustainable and institutionalized HTA systems requires in-country expertise and active participation from a range of stakeholders. Stakeholder participation in identifying HTA topics and conducting relevant research will enhance the use of HTA evidence produced for decision making. Therefore, the identified training needs for HTA and possible research topics should be considereda priority in establishing HTA for evidence-informed policy making for achieving UHC particularly among the most vulnerable people in Nigeria.
Evaluate the correlation of electrolytes with biochemical parameters in biological samples of Parkinson’s disease patients at different stages
Authors: Afridi Hassan Imran , Rajput Kanwal , Kazi Tasneem Gul , Talpur Farah Naz , Baig Jameel Ahmed
Published: April 2020

Background: Neurodegeneration is complex and multifaceted leading to many chronic diseases like Parkinson’s disorder. Electrolytes imbalance have significant role in the pathophysiology of neurological disorders, which might be serve as a bio-indicator of the neurological problems. In present study, the disturbances of electrolytes (calcium, magnesium, sodium and potassium) and its correlation with biochemical parameters in patients with Parkinson’s at different stages with related to referent were studied. Methods: The biological samples were collected from patients recently diagnosed for mild Parkinson disease (MPD) (n=95) as well as chronic PD (CPD) patients, diagnosed for last 5 to 10 years (n=125).The Precision of digestion method was verified by applying matrixes matched certified reference materials of biological samples. The recovery of electrolytes was obtained in the range of 98.4–99.1 % of certified reference materials. The electrolytes concentrations were measured by acid digested biological samples preliminary analysis through flame atomic absorption spectrometry. Results: The experimental data indicated the content of Calcium and Magnesium were found to be higher in scalp hair samples of both patients while Sodium and Potassium showed inverse relation (p<0.05 for both groups). Electrolytes levels in blood serum and plasma was found to be lower in both types of patient groups than healthy groups (p<0.01). Conclusions: These results suggest a disturbance in the elemental homeostasis during the diseases of PD at different stages. In spite of, additional work is proposed to study the actual correlation among micro elemental level and the grade of diseases in neurological sick person.
Prevalence and Correlates of Depressive Symptoms Among High School Adolescent Girls in Southern Uganda
Authors: Nabunya Proscovia , Damulira Christopher , Byansi William , Muwanga Joelynn , Bahar Ozge Sensoy , Namuwonge Flavia , Ighofose Eloho , Brathwaite Rachel , Tumwesige Wilberforce , Ssewamala Fred M
Published: April 2020

BackgroundIn sub-Saharan Africa (SSA), adolescent girls and young women are three times more likely than boys to have depressive disorders. Understanding adolescents’ unique and common vulnerabilities and protective factors is essential for the development of appropriate interventions and programming focused on child and adolescent mental health. This paper examines the prevalence and predictors of depressive symptoms among high school adolescent girls in southern Uganda.MethodsBaseline data from 1260 adolescent girls (14–17 years), recruited from 47 secondary schools were utilized. Depressive symptoms were estimated using the 21-item Beck’s Depression Inventory. Hierarchical linear regression modelling was utilized to estimate key predictors of depressive symptoms among adolescent girls.ResultsOf the total sample, 16.35% (n = 206) reported severe depressive symptoms and almost one in every three adolescent girls interviewed (29.68%, n = 374) reported moderate symptoms. These symptoms were more prevalent among older adolescents (16 years and above). In addition, family relationships, social support, as well as measures of psychological wellbeing (self-concept and self-esteem) were all associated with lower levels of depressive symptoms. Hopelessness was associated with higher levels of depressive symptoms among adolescent girls.ConclusionFindings from this study contribute to the limited literature on the prevalence of depressive symptoms among adolescent girls. Given that depressive symptoms tend to increase during later adolescence, our findings support increasing calls for early screening and detection of poor mental health functioning to facilitate timely referral to care and treatment. Findings may also inform the development and incorporation of gender-specific mental health components in programming targeting adolescent girls, in low-resource communities in SSA.Trial Registration:This trial was registered with ClinicalTrials.gov (registration number: NCT03307226) on 11 October 2017.
Antineuroinflammatory effects of dl-3-n-butylphthalide conferred by stimulation of Foxp3 and Ki-67 in an ischemic stroke model
Authors: Liu Xi , Liu Runzhe , Fu Dongxu , Wu Hao , Zhao Xin , Sun Yi , Wang Meng , Pu Xiaoping
Published: April 2020

Background

Dl-3-n-butylphthalide (NBP) has been widely used for the treatment of ischemic stroke in China. However, its mechanisms of action have not been fully elucidated.
Methods

We established a permanent middle cerebral artery occlusion (pMCAO) rat model and administered 4 mg/kg/d NBP by tail vein injection for 9 days. Changes in some molecules related to neuroinflammation, neovascularization and nerve regeneration were observed, such as MALDI-TOF MSI to study the distribution of phospholipids in the brain, LA-ICP MSI to observe the changes of Foxp3, Ki-67 and pCREB, immunohistochemistry to investigate NLRP3 and its downstream inflammatory products Caspase-1 and IL-1β.
Results

These results showed that NBP attenuated ischemic damage in pMCAO rats, accompanied by improving neurological deficits. It was revealed for the first time in an animal stroke model that NBP decreased the levels of PE (18:0), NLRP3, Caspase-1 and IL-1β, while increasing the levels of several phospholipids, such as PA (16:0/18:1), PA (18:0/22:6), PE (16:0/22:6), PE (P-18:0/22:6), PE (18:0/22:6), PS (18:0/22:6), PI (18:0/20:4), Foxp3, Ki-67 and pCREB, in the ischemic brain region.
Conclusion

These results provide evidence that NBP can reduce neuroinflammation in brain tissue and promote the regeneration of nerves and blood vessels, thus exerting a protective effect on neuromorphology and function.
Supplementation of Postbiotic RI11 Improves Antioxidant Enzymes Activity, Upregulated Gut Barrier Genes and Reduced Cytokines, Acute Phase Proteins and HSP70 Gene Expression Levels in Heat-Stressed Broilers
Authors: Humam Ali Merzza , Loh Teck Chwen , Foo Hooi Ling , Izuddin Wan Ibrahim , Zulkifli Idrus , Samsudin Anjas Asmara , Mustapha Noordin Mohamed
Published: April 2020

Background

To alleviate the adverse impacts of stressful environmental conditions on poultry and promoting the animal's health and growth performance, antibiotics have been added to poultry diets as growth promoters. Nevertheless, improper and overuse of antibiotics as feed additives have resulted the emergence of antibiotic-resistant bacteria and increased the levels of antibiotic residues in animal products, which have disastrous effects on the health of both animals and humans. Postbiotics produced from probiotic Lactobacillus plantarum have been the recent research of interest as dietary additives for livestock and potential alternatives to antibiotics. However, there is very scarce of study has considered the effect of postbiotics on broilers under heat stress. The aim of this work was to evaluate the impacts of feeding different levels of postbiotic RI11 on antioxidant enzyme activity, physiological stress indicators, cytokines and gut barrier genes expression in broilers under heat stress.
Materials and Methods

A total of 252 male Cobb 500 were fed with 1 of 7 diets: NC (negative control, 0.0% RI11) basal diet; OTC (positive control) NC + 0.02% (w/w) oxytetracycline; AA (antioxidant control) NC + 0.02% (w/w) ascorbic acid. Four further groups were NC + 0.2, 0.4, 0.6 and 0.8% postbiotic RI11 (v/w) of the respective levels.
Results

Supplementation of different levels of postbiotic RI11 increased plasma glutathione peroxidase, catalase and glutathione enzymes activity. Postbiotic RI11 groups upregulated the mRNA expression of interleukin 10 and downregulated of interleukin 8, tumor necrosis factor-alpha, heat shock protein 70 and alpha 1- acid glycoprotein levels compared to the NC and OTC groups. Feeding various doges of postbiotic RI11 improved the integrity of the intestinal barrier by the upregulation of zonula occludens-1 and mucin2 mRNA expressions. However, no difference was observed in claudin1, ceruloplasmin, interleukin 6, interleukin 2 and interferon expression, but downregulation for occludin expression as compared with the NC group. Supplementation of postbiotic RI11 in different levels quadratically increased the plasma glutathione peroxidase, catalase and glutathione, interleukin 10, mucin2 and zonula occludens-1 mRNA expression, and reduced plasma interleukin 8, tumor necrosis factor-alpha, alpha 1- acid glycoprotein and heat shock protein 70 mRNA expression. Supplementation of postbiotic RI11 at level 0.6% was sufficient to achieve the improvement in health of broiler chickens under heat stress as compared to other levels.
Conclusions

The results suggested that postbiotic produced from L. plantarum RI11 particularly at level 0.6% (v/w) could be used as an alternative to antibiotics and natural sources of antioxidants in the poultry industry.