bluuebunny/crossref_metadata_2025 huggingface dataset:
Concussed patients with visually induced dizziness exhibit increased ocular torsion and vertical vergence during optokinetic gaze-stabilization
Authors: Wibble Tobias , Frattini D. , Benassi M. , Bolzani R. , Pansell T.
Published: March 2023

Visually Induced Dizziness (VID) is a common post-concussion sequalae that remains poorly understood and difficult to quantify. The present study aims to identify biomarkers for VID in the form of gaze-stabilizing eye movements. Nine patients with post-commotio VID and nine age-matched healthy controls were recruited by physiotherapists at a local neurorehabilitation centre. Torsional and vergence eye movements were recorded while participants viewed a series of optokinetic rotations where the central- and peripheral regions moved coherently, incoherently, or semi-randomly. Results showed that vergence and torsional velocities were increased in VID patients, reflecting increased oculomotor gain to visual motion, and that responses correlated with symptom severity. Coherent stimulation produced fastest torsional slow-phases across all participants; when faced with confliction directional information, eye movements tended to follow the direction of the central visual field, albeit at slower velocities than during coherent motion, meaning that while torsion was sensitive to visual content of the entire visual field it expressed directional preference to the central stimulation. In conclusion, post-commotio VID was associated with faster slow-phases during optokinetic gaze-stabilization, with both vergence and torsion being correlated to symptom intensity. As torsional tracking remains inaccessible using commercial eye-trackers, vertical vergence may prove particularly accessible for clinical utility.
Transcriptomic analysis of the cerebral hippocampal tissue in spontaneously hypertensive rats exposed to acute hypobaric hypoxia: associations with inflammation and energy metabolism
Authors: Chang Wei , Cui Jinxiu , Li Yajuan , Zang Kehai , Zhang Xutao , Zhang Zhuoru , Jiang Yihong , Ma Qianqian , Qu Shuai , Liu Fengzhou , Xue Junhui
Published: March 2023

We evaluated the effect of acute hypobaric hypoxia (AHH) on the hippocampal region of the brain in early-stage spontaneously hypertensive male rats. The rats were classified into a control (ground level; ~ 400 m altitude) group and an AHH experimental group placed in an animal hypobaric chamber at a simulated altitude of 5500 m for 24 h. RNA-Seq analysis of the brains and hippocampi showed that differentially expressed genes (DEGs) were primarily associated with ossification, fibrillar collagen trimer, and platelet-derived growth factor binding. The DEGs were classified into functional categories including general function prediction, translation, ribosomal structure and biogenesis, replication, recombination, and repair. Pathway enrichment analysis revealed that the DEGs were primarily associated with relaxin signaling, PI3K-Akt signaling, and amoebiasis pathways. Protein–protein interaction network analysis indicated that 48 DEGs were involved in both inflammation and energy metabolism. Further, we performed validation experiments to show that nine DEGs were closely associated with inflammation and energy metabolism, of which two (Vegfa and Angpt2) and seven (Acta2, Nfkbia, Col1a1, Edn1, Itga1, Ngfr, and Sgk1) genes showed up and downregulated expression, respectively. Collectively, these results indicated that inflammation and energy metabolism-associated gene expression in the hippocampus was altered in early-stage hypertension upon AHH exposure.
Extinction drives a discontinuous temporal pattern of species–area relationships in a microbial microcosm system
Authors: Deng Wei , Li Na , Zhang Chao-Zhi , An Rui , Yang Xiao-Yan , Xiao Wen
Published: March 2023

As the most potential ecological "law", the mechanism of the species-area relationship (SAR) remains controversial. Essentially, the SAR addresses the relationship between regional area and biodiversity, shaped by speciation, extinction and dispersal processes. Extinction is the process of loss and a direct cause of species richness differences in community. Therefore, it is crucial to elucidate the role of extinction in shaping SAR. Since the extinction process has temporal dynamics, we propose the hypothesis that the occurrence of SAR should also have temporal dynamics. Here, we designed independent closed microcosm systems, in which dispersal/speciation can be excluded/neglected to reveal the role of extinction in shaping the temporal dynamics pattern of SAR. We find that extinction can shape SAR in this system independent of the dispersal and speciation process. Due to the temporal dynamics of the extinction, SAR was temporally discontinuous. The small-scale extinctions modified community structure to promote ecosystem stability and shaped SAR, while mass extinction pushed the microcosm system into the next successional stage and dismissed SAR. Our result suggested that SAR could serve as an indicator of ecosystem stability; moreover, temporal discontinuity can explain many controversies in SAR studies.
Ex vivo expansion of circulating tumour cells (CTCs)
Authors: Mohamed Bashir M. , Ward Mark P. , Bates Mark , Spillane Cathy D. , Kelly Tanya , Martin Cara , Gallagher Michael , Heffernan Sheena , Norris Lucy , Kennedy John , Saadeh Feras Abu , Gleeson Noreen , Brooks Doug A. , Brooks Robert D. , Selemidis Stavros , O’Toole Sharon , O’Leary John J.
Published: March 2023

Circulating tumour cells (CTCs) are a critical intermediate step in the process of cancer metastasis. The reliability of CTC isolation/purification has limited both the potential to report on metastatic progression and the development of CTCs as targets for therapeutic intervention. Here we report a new methodology, which optimises the culture conditions for CTCs using primary cancer cells as a model system. We exploited the known biology that CTCs thrive in hypoxic conditions, with their survival and proliferation being reliant on the activation of hypoxia-inducible factor 1 alpha (HIF-1α). We isolated epithelial-like and quasi-mesenchymal CTC phenotypes from the blood of a cancer patient and successfully cultured these cells for more than 8 weeks. The presence of CTC clusters was required to establish and maintain long-term cultures. This novel methodology for the long-term culture of CTCs will aid in the development of downstream applications, including CTC theranostics.
Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery
Authors: Nori Pouria , Haghshenas Rouhollah , Aftabi Younes , Akbari Hakimeh
Published: March 2023

Myocardial infarction (MI) affects many molecular pathways in heart cells, including the Ido1-KYN-Ahr axis. This pathway has recently been introduced as a valuable therapeutic target in infarction. We examined the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on the axis in the heart tissue of male Wistar rats with occluded left anterior descending (OLAD). Thirty rats (age 10–12 weeks, mean weight 275 ± 25 g) were divided into five groups with 6 animals: Control (Ct) group, MICT group, rats with OLAD as MI group, rats with OLAD treated with MICT (MIMCT group) and rats with OLAD treated with HIIT (MIHIIT group). Rats performed the training protocols for 8 weeks, 5 days a week. HIIT included 7 sets of 4 min running with an intensity of 85–90% VO2max and 3 min of recovery activation between sets. MICT included continuous running at the same distance as HIIT with an intensity of 50–60% VO2max for 50 min. The expressions of Ahr, Cyp1a1, and Ido1 were assayed by real-time PCR. Malondialdehyde (MDA) and Kynurenine levels, and AHR, CYP1A1, and IDO1 proteins were detected using ELISA. Data were analyzed using the ANOVA and MANOVA tests. Compared to the CT group, MI caused an increase in all studied factors, but only statistically significant (P < 0.05) for MDA and IDO1. With a greater effect of HIIT, both protocols significantly lowered the proteins expressions in the MIHIIT and MIMCT groups, compared with the MI group (P < 0.001). In healthy rats, only AHR protein significantly decreased in the MICT group compared to the Ct group (P < 0.05). HIIT and MICT protocols significantly reduced the gene and protein expression of Cyp1a1 (P < 0.05) and Ido1 (P < 0.01), and HIIT had a greater effect. In conclusion, both protocols were effective at reducing the levels of Ido1-Kyn-Ahr axis components and oxidative stress in the infarcted heart tissue and HIIT had a higher significant effect.
Exploring regional aspects of 3D facial variation within European individuals
Authors: Wilke Franziska , Herrick Noah , Matthews Harold , Hoskens Hanne , Singh Sylvia , Shaffer John R. , Weinberg Seth M. , Shriver Mark D. , Claes Peter , Walsh Susan
Published: March 2023

Facial ancestry can be described as variation that exists in facial features that are shared amongst members of a population due to environmental and genetic effects. Even within Europe, faces vary among subregions and may lead to confounding in genetic association studies if unaccounted for. Genetic studies use genetic principal components (PCs) to describe facial ancestry to circumvent this issue. Yet the phenotypic effect of these genetic PCs on the face has yet to be described, and phenotype-based alternatives compared. In anthropological studies, consensus faces are utilized as they depict a phenotypic, not genetic, ancestry effect. In this study, we explored the effects of regional differences on facial ancestry in 744 Europeans using genetic and anthropological approaches. Both showed similar ancestry effects between subgroups, localized mainly to the forehead, nose, and chin. Consensus faces explained the variation seen in only the first three genetic PCs, differing more in magnitude than shape change. Here we show only minor differences between the two methods and discuss a combined approach as a possible alternative for facial scan correction that is less cohort dependent, more replicable, non-linear, and can be made open access for use across research groups, enhancing future studies in this field.
Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis
Authors: Bielawiec Patrycja , Dziemitko Sylwia , Konstantynowicz-Nowicka Karolina , Chabowski Adrian , Dzięcioł Janusz , Harasim-Symbor Ewa
Published: March 2023

Obesity is one of the principal public health concerns leading to disturbances in glucose and lipid metabolism, which is a risk factor for several chronic diseases, including insulin resistance, type 2 diabetes mellitus, and cardiovascular diseases. In recent years, it turned out that cannabidiol (CBD) is a potential therapeutic agent in the treatment of obesity and its complications. Therefore, in the present study, we used CBD therapy (intraperitoneal injections in a dose of 10 mg/kg of body mass for 14 days) in a rat model of obesity induced by a high-fat diet (HFD). Gas–liquid chromatography and Western blotting were applied in order to determine the intramuscular lipid content and total expression of selected proteins in the white and red gastrocnemius muscle, respectively. Based on fatty acid composition, we calculated de novo lipogenesis ratio (16:0/18:2n-6), desaturation ratio (18:1n-9/18:0), and elongation ratios (18:0/16:0, 20:0/18:0, 22:0/20:0 and 24:0/22:0), in the selected lipid fractions. Two-week CBD administration significantly reduced the intramuscular fatty acids (FAs) accumulation and inhibited de novo lipogenesis in different lipid pools (in the free fatty acid, diacylglycerol, and triacylglycerol fractions) in both muscle types, which coincided with a decrease in the expression of membrane fatty acid transporters (fatty acid translocase, membrane-associated fatty acid binding protein, and fatty acid transport proteins 1 and 4). Moreover, CBD application profoundly improved the elongation and desaturation ratios, which was in line with downregulated expression of enzymes from the family of elongases and desaturases regardless of the metabolism presented by the muscle type. To our knowledge, this study is the first that outlines the novel effects of CBD action on skeletal muscle with different types of metabolism (oxidative vs. glycolytic).
Discovery and comparative genomic analysis of a novel equine anellovirus, representing the first complete Mutorquevirus genome
Authors: Fisher Mathew , Nebroski Michelle , Davies Jennifer , Janzen Eugene , Sullivan Daniel , Lung Oliver
Published: March 2023

The complete genome of a novel torque teno virus species (Torque teno equus virus 2 (TTEqV2) isolate Alberta/2018) was obtained by high-throughput sequencing (HTS) of nucleic acid extracted from the lung and liver tissue of a Quarter Horse gelding that died of nonsuppurative encephalitis in Alberta, Canada. The 2805 nucleotide circular genome is the first complete genome from the Mutorquevirus genus and has been approved as a new species by the International Committee on Taxonomy of Viruses. The genome contains several characteristic features of torque teno virus (TTV) genomes, including an ORF1 encoding a putative 631 aa capsid protein with an arginine-rich N-terminus, several rolling circle replication associated amino acid motifs, and a downstream polyadenylation signal. A smaller overlapping ORF2 encodes a protein with an amino acid motif (WX7HX3CXCX5H) which, in general, is highly conserved in TTVs and anelloviruses. The UTR contains two GC-rich tracts, two highly conserved 15 nucleotide sequences, and what appears to be an atypical TATA-box sequence also observed in two other TTV genera. Codon usage analysis of TTEqV2 and 11 other selected anelloviruses from five host species revealed a bias toward adenine ending (A3) codons in the anelloviruses, while in contrast, A3 codons were observed at a low frequency in horse and the four other associated host species examined. Phylogenetic analysis of TTV ORF1 sequences available to date shows TTEqV2 clusters with the only other currently reported member of the Mutorquevirus genus, Torque teno equus virus 1 (TTEqV1, KR902501). Genome-wide pairwise alignment of TTEqV2 and TTEqV1 shows the absence of several highly conserved TTV features within the UTR of TTEqV1, suggesting it is incomplete and TTEqV2 is the first complete genome within the genus Mutorquevirus.
Wearable device and smartphone data quantify ALS progression and may provide novel outcome measures
Authors: Johnson Stephen A. , Karas Marta , Burke Katherine M. , Straczkiewicz Marcin , Scheier Zoe A. , Clark Alison P. , Iwasaki Satoshi , Lahav Amir , Iyer Amrita S. , Onnela Jukka-Pekka , Berry James D.
Published: March 2023

Amyotrophic lateral sclerosis (ALS) therapeutic development has largely relied on staff-administered functional rating scales to determine treatment efficacy. We sought to determine if mobile applications (apps) and wearable devices can be used to quantify ALS disease progression through active (surveys) and passive (sensors) data collection. Forty ambulatory adults with ALS were followed for 6-months. The Beiwe app was used to administer the self-entry ALS functional rating scale-revised (ALSFRS-RSE) and the Rasch Overall ALS Disability Scale (ROADS) surveys every 2–4 weeks. Each participant used a wrist-worn activity monitor (ActiGraph Insight Watch) or an ankle-worn activity monitor (Modus StepWatch) continuously. Wearable device wear and app survey compliance were adequate. ALSFRS-R highly correlated with ALSFRS-RSE. Several wearable data daily physical activity measures demonstrated statistically significant change over time and associations with ALSFRS-RSE and ROADS. Active and passive digital data collection hold promise for novel ALS trial outcome measure development.
Primary cilia sense glutamine availability and respond via asparagine synthetase
Authors: Steidl Maria Elena , Nigro Elisa A. , Nielsen Anne Kallehauge , Pagliarini Roberto , Cassina Laura , Lampis Matteo , Podrini Christine , Chiaravalli Marco , Mannella Valeria , Distefano Gianfranco , Yang Ming , Aslanyan Mariam , Musco Giovanna , Roepman Ronald , Frezza Christian , Boletta Alessandra
Published: March 2023

Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring and organelle reorganization. Primary cilia are microtubule-based organelles at the cell surface, capable of integrating multiple metabolic and signalling cues, but their precise sensory function is not fully understood. Here we show that primary cilia respond to nutrient availability and adjust their length via glutamine-mediated anaplerosis facilitated by asparagine synthetase (ASNS). Nutrient deprivation causes cilia elongation, mediated by reduced mitochondrial function, ATP availability and AMPK activation independently of mTORC1. Of note, glutamine removal and replenishment is necessary and sufficient to induce ciliary elongation or retraction, respectively, under nutrient stress conditions both in vivo and in vitro by restoring mitochondrial anaplerosis via ASNS-dependent glutamate generation. Ift88-mutant cells lacking cilia show reduced glutamine-dependent mitochondrial anaplerosis during metabolic stress, due to reduced expression and activity of ASNS at the base of cilia. Our data indicate a role for cilia in responding to, and possibly sensing, cellular glutamine levels via ASNS during metabolic stress.
Stepwise increased spatial provenance contrast on the Chinese Loess Plateau over late Miocene-Pleistocene
Authors: Peng Wenbin , Zhang Haobo , Pullen Alex , Li Maotong , Pan Baotian , Xiao Wenjiao , Nie Junsheng
Published: March 2023

The Miocene–Holocene dust sequences composing the Chinese Loess Plateau are one of Earth’s most complete terrestrial eolian sediment archives. Here we present a zircon Uranium-Lead geochronology dataset for the eolian sequence from the northeastern plateau and compare the results with those from the central plateau. These data show a trend of increasing spatial provenance contrast from the late Miocene to the Pleistocene. This can be reasonably explained by the late Miocene uplift of the Qilian Shan, Pliocene intensification and increased variations of the Asian summer monsoons, Pleistocene intensification of Northern Hemisphere glaciations, and possible formation of the current Yellow River course. These events changed sediment supply, availability, and wind strength, causing the observed pattern. These interpretations challenge assertions linking dust accumulation on the Loess Plateau primarily to aridification within the Asian interior, but rather point to a confluence of surface processes involving exhumation, monsoon, ice ages, and river reorganization.
Study and voltammetric determination of fipronil in bovine lactose-free milk by differential pulse voltammetry using a carbon paste electrode
Authors: Diniz Juliana Aparecida , Okumura Leonardo Luiz , Filomena de Souza Silva Astréa , Oliveira André Fernando , Gurgel Alexandre , Liberato Priscila Azevedo , Aleixo Herbert , Silva. Júnio Gonçalves
Published: March 2023

A novel voltammetric screening method has been developed for the rapid determination of fipronil (FPN) residues in lactose-free milk samples with the use of a carbon-paste electrode (CPE) by differential-pulse voltammetry (DPV).
A computational investigation of the decomposition of acetic acid in H-SSZ-13 and its role in the initiation of the MTO process
Authors: Huber Philipp , Plessow Philipp N.
Published: March 2023

The zeolite-catalyzed reaction of acetic acid is important in the direct utilization of biomass and also plays a role in the reactivity of oxygenates in the methanol-to-olefins (MTO) process.
Promotional role of NiCu alloy in catalytic performance and carbon properties for CO2-free H2 production from thermocatalytic decomposition of methane
Authors: Xu Mengze , Lopez-Ruiz Juan A. , Riedel Nickolas W. , Weber Robert S. , Bowden Mark E. , Kovarik Libor , Jiang Changle , Hu Jianli , Dagle Robert A.
Published: March 2023

The addition of Cu to Ni inhibits catalyst deactivation and changes carbon co-product morphology during the thermocatalytic decomposition of methan.
Structure sensitivity of alumina- and zeolite-supported platinum ammonia slip catalysts
Authors: Marchuk Vasyl , Huang Xiaohui , Grunwaldt Jan-Dierk , Doronkin Dmitry E.
Published: March 2023

NH3 is effectively oxidised on Pt via O-activated dissociation when a minimum particle size to contain a favourable surface atom configuration is reached. Different mechanisms were found to govern NH3 oxidation on nanoparticles and single sites.
Luminescent AgGaSe2/ZnSe nanocrystals: rapid synthesis, color tunability, aqueous phase transfer, and bio-labeling application
Authors: Li Tong , Liu Cong , Li Ruyi , Huang Xiaohua , Qi Xiaofei , Mi Xiaohan , Bai Tianyu , Xing Shanghua
Published: March 2023

High-quality AgGaSe2 nanocrystals can be rapidly synthesized in 2 minutes by a facile colloidal method, and their luminescence optimization, aqueous phase transfer, and fluoroimmunoassay for PSA were investigated.
Evaluation of low-cost gas sensors to quantify intra-urban variability of atmospheric pollutants
Authors: Baruah Arunik , Zivan Ohad , Bigi Alessandro , Ghermandi Grazia
Published: March 2023

Low-cost electrochemical air quality sensors can provide deep insights into the intra-urban variability of different air pollutants after proper calibration using field co-location with regulatory Air Quality Monitoring stations.
Caffeine can alleviate non-alcoholic fatty liver disease by augmenting LDLR expression via targeting EGFR
Authors: Huang Ye-Wei , Wang Li-Tian , Zhang Meng , Nie Yan , Yang Jin-Bo , Meng Wen-Luer , Wang Xuan-Jun , Sheng Jun
Published: March 2023

Our results demonstrate that caffeine stimulates the EGFR-ERK1/2 pathway to increase the LDLR expression and ameliorate nonalcoholic fatty liver disease (NAFLD) in HFD-fed ApoE KO mice.
Study onLactiplantibacillus plantarumR6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota–gut–brain axis
Authors: Zhao Lina , Li Dongyao , Chitrakar Bimal , Li Chen , Zhang Na , Zhang Shaogang , Wang Xinyu , Wang Miaoshu , Tian Hongtao , Luo Yunbo
Published: March 2023

Through microbiota–gut–brain axis,L. plantarumR6-3 improved intestine SCFAs, monoamine neurotransmitter, BDNF, HPA axis, immune and oxidative stress through regulating gut microbiota, thereby preventing CUMS-induced depression behavior in mice.
Mapping complex profiles of light intensity with interferometric lithography
Authors: Holmes Joseph , Zhang Mi , Greibe Tine , Schaich William L. , Jacobson Stephen C. , Dragnea Bogdan
Published: March 2023

Complex light intensity patterns formed by closely-spaced multiple apertures in a metal film can be faithfully mapped with sub-wavelength resolution, from near-field to far-field, by interferometric lithography.
Epitaxial growth of crystal phase quantum dots in III–V semiconductor nanowires
Authors: Lozano Miguel Sinusia , Gómez Víctor J.
Published: March 2023

This review summarizes the epitaxial growth of crystal phase quantum dots in nanowires in terms of basic concepts, control of the crystal phase in the axial direction, shell growth in the radial direction and optical and electronic properties.
Nanoscale compositional segregation in epitaxial AlScN on Si (111)
Authors: Zhang Xiaoman , Stach Eric A. , Meng W. J. , Meng Andrew C.
Published: March 2023

We report the growth of epitaxial wurtzite AlScN thin films on Si (111) substrates with a wide range of Sc concentrations using ultra-high vacuum reactive sputtering.
Contrasting thermoresponsiveness of stereoisomers of a dense 1,2,3-triazole polymer carrying amide side chains
Authors: Okuno Koji , Miura Junji , Yamasaki Shota , Nakahata Masaki , Kamon Yuri , Hashidzume Akihito
Published: March 2023

Thermoresponsive behavior of stereoisomers of a dense triazole polymer was studied; mixtures of the isotactic one underwent thermoresponsive gel-to-sol transition, and aqueous solutions of the syndiotactic one underwent LCST-type phase transition.
1,3,5-Triazine and dithienothiophene-based conjugated polymers for highly effective photocatalytic hydrogen evolution
Authors: Yang Jie , Liu Yahu A. , Zhai Ming-Ming , Qin Jun-Jie , Hu Wei-bo , Yang Hui , Wen Ke
Published: March 2023

Two conjugated organic photocatalysts, thiophene-based TzDTT and thiophene 4,4-dioxide-based TzDTDO, demonstrate remarkably different photocatalytic hydrogen evolution activities in various reaction solution systems.
Tailoring metal sites of FeCo-MOF nanozymes for significantly enhanced peroxidase-like activity
Authors: Cheng Xiqing , Xie Yameng , Li Guang , Zheng Zhiping , Kuang Qin
Published: March 2023

A mixed metal–organic framework (FeCo-MOF-H2) with excellent peroxidase-like catalytic activity was successfully prepared, which showed great application potential in the detection of H2O2 and glutathione.
Synthesis of quinol-type heterobiarylsviaan acid-catalyzed heteroannulation of alkynes ando-aminobenzaldehydes
Authors: Jian Qing-Song , Gou Bo-Bo , Wang Shao-Jie , Sun Huai-Ri , Sharif Atif , Wang Yong-Qiang , Zhou Ling , Chen Jie
Published: March 2023

A simple and efficient heteroannulation reaction for the synthesis of 1-(quinolin-2-yl)naphthalen-2-ols has been developed, and the products can be transformed to axially chiral arylquinolines by dynamic kinetic resolution.
Fe-BPsalan complex-catalyzed asymmetric 1,3-dipolar [3 + 2] cycloaddition reaction of N,N′-cyclic azomethine imines with α,β-unsaturated acyl imidazoles
Authors: Lu Hao , Chen Kai-Ge , Li Gong-Xin , Zhan Kun , Wang Hao-Yang , Xu Zhen-Jiang , Che Chi-Ming
Published: March 2023

A practical iron-catalyzed asymmetric 1,3-dipolar cycloaddition of N,N′-cyclic azomethine imines with α,β-unsaturated acyl imidazoles was developed to afford N,N′-bicyclic pyrazolidine in good yields and excellent stereoselectivities (up to 98% ee).
NiIIand CuIIcomplexes of a salen ligand bearing ferrocenes in its secondary coordination sphere
Authors: Sailer Rachel , VandeVen Warren , Teindl Kaeden , Chiang Linus
Published: March 2023

The synthesis and characterization of two novel NiIIand CuIIsalen complexes containing ferrocene moieties in their secondary coordination sphere are described herein.
Effect of novel graphitic carbon/NiO hole transporting electrode on the photovoltaic and optical performance of semi-transparent perovskite solar cells
Authors: Bhandari Shubhranshu , Valsalakumar Sreeram , Chanchangi Yusuf , Selvaraj Prabhakaran , Mallick Tapas K.
Published: March 2023

Perovskite devices can play a critical role as tunable semi-transparent photovoltaics managing the buildings' energy health for energy harvesting, storage and utilization.
Synthesis of cationic β-cyclodextrin functionalized silver nanoparticles and their drug-loading applications
Authors: Yang Ke , Liu Junfeng , Luo Laichun , Li Meilin , Xu Tanfang , Zan Junfeng
Published: March 2023

The synthesis of cationic β-cyclodextrin functionalized silver nanocomposites that reserve the drug loading function, which was demonstrated by inclusion interaction with thymol.
Degradable polyisoprene by radical ring-opening polymerization and application to polymer prodrug nanoparticles
Authors: Lages Maëlle , Pesenti Théo , Zhu Chen , Le Dao , Mougin Julie , Guillaneuf Yohann , Nicolas Julien
Published: March 2023

Radical ring-opening copolymerization of isoprene and dibenzo[c,e]oxepane-5-thioneviafree-radical and controlled radical polymerizations led to degradable polyisoprene under basic, oxidative and physiological conditions with application to prodrug nanoparticles.
Building Streptomyces albus as a chassis for synthesis of bacterial terpenoids
Authors: Hu Yi Ling , Zhang Qi , Liu Shuang He , Sun Jia Li , Yin Fang Zhou , Wang Zi Ru , Shi Jing , Jiao Rui Hua , Ge Hui Ming
Published: March 2023

We built a Streptomyces expression system to discovery bacterial terpenoids. Though genome mining and expression of terpene BGCs, 11 terpene skeletons including 3 new ones, and 18 novel distinct terpenoids were isolated and characterized.
A lattice model of ternary mixtures of lipids and cholesterol with tunable domain sizes
Authors: Sarkar Tanmoy , Farago Oded
Published: March 2023

We present a lattice model of ternary lipid–cholesterol mixtures, exhibiting either local or thermodynamic liquid–liquid coexistence.
Bacteria-inspired robotic propulsion from bundling of soft helical filaments at low Reynolds number
Authors: Lim Sangmin , Yadunandan Achyuta , Khalid Jawed M.
Published: March 2023

The bundling of flagella is known to create a “run” phase, where the bacteria moves in a nearly straight line rather than making changes in direction.
Structured aqueous processed lignin-based NMC cathodes for energy-dense LIBs with improved rate capability
Authors: Bryntesen Silje Nornes , Finne Per Håkon , Svensson Ann Mari , Shearing Paul R. , Tolstik Nikolai , Sorokina Irina T. , Vinje Jakob , Lamb Jacob Joseph , Burheim Odne Stokke
Published: March 2023

The cost and environmental impact of Li-ion batteries can be reduced through aqueous processing of cathode materials. Here, we used aqueous processing to prepare lignin-based NMC111 cathodes for Li-ion batteries with enhanced rate capability.
Recent progress in block copolymer soft-template-assisted synthesis of versatile mesoporous materials for energy storage systems
Authors: Kim Keon-Woo , Park Bomi , Kim Jun , Jo Changshin , Kim Jin Kon
Published: March 2023

Various mesoporous materials synthesized from block copolymer soft-template-assisted methods and their application in energy storage systems.
Pseudo single lithium-ion conductors enabled by a metal–organic framework with biomimetic lithium-ion chains for lithium metal batteries
Authors: Shen Jian-Qiang , Song Ying-Li , He Chun-Ting , Zhang Chen , Lu Xing , Qi Zhikai , Lu Yunfeng , Zhang Xian-Ming
Published: March 2023

A unique single lithium-ion conductor (SLIC) contains lithium-ion chains was synthesised, which exhibits high lithium ionic conductivity and low activation energy. LiFePO4|Li cell with such SLIC exhibits significantly extended the cycling life.
Mechanism and origins of ligand-controlled regioselectivity of copper-catalyzed borocarbonylation of imines with B2pin2 and alkyl iodides: a computational study
Authors: Song Xinyi , Wu Hongli , Yang Jinjin , Zhao Wentao , Huang Genping
Published: March 2023

Copper-catalyzed borocarbonylation of imines with B2pin2 and alkyl iodides has been investigated by means of DFT calculations. The detailed reaction mechanisms and the origins of the ligand-controlled regioselectivity were elucidated.
Copper(i)-catalyzed multicomponent interrupted click reaction: modular synthesis of triazole sulfides from elemental sulfur
Authors: Sun Pengfei , Wang Weiguo , Lai Jilong , Yan Huang , Tung Chen-Ho , Xu Zhenghu
Published: March 2023

A new multicomponent copper(i)-catalyzed interrupted click reaction which allows the rapid modular synthesis of multisubstituted triazole sulfides including various medium-sized and macrocycles in one-step from elemental sulfur was reported.
Utilizing modified cellulose nanoparticles derived from a plant loofah sponge to improve the removal of diazinon insecticide from an aqueous medium
Authors: Hassan Asaad F. , Alshandoudi Laila M. , Shaltout Walaa A.
Published: March 2023

Organophosphate insecticides, such as diazinon, have been well investigated to pose health and environmental risks.
Synthesis, characterization and exploration of photovoltaic behavior of hydrazide based scaffolds: a concise experimental and DFT study
Authors: Haroon Muhammad , Akhtar Tashfeen , Khalid Muhammad , Mehmood Hasnain , Asghar Muhammad Adnan , Baby Rabia , Orfali Raha , Perveen Shagufta
Published: March 2023

Solar energy being a non-depleting energy resource, has attracted scientists' attention to develop efficient solar cells to meet energy demands.
Design of blueberry anthocyanin/TiO2 composite layer-based photoanode and N-doped porous blueberry-derived carbon-loaded Ni nanoparticle-based counter electrode for dye-sensitized solar cells
Authors: Qin Xiang , Liu Jingjing , Teng Genhui , Liu Baorui , Xie Yanhui , Ma Lin , Hu Dongying
Published: March 2023

In this study, we have creatively designed photoanode and counter electrodes materials with blueberries as the key performance improvement, and verified the contribution of blueberry to the photoelectric conversion performance of DSSCs.
Molybdenum chloride double perovskites: dimensionality control of optical and magnetic properties
Authors: Binwal Devesh Chandra , Mudoi Prashurya Pritam , Panda Debendra Prasad , Vishnoi Pratap
Published: March 2023

We report molybdenum chloride based novel halide double perovskites of different dimensionalities which show dimensionality dependent magnetic exchange interaction and optical absorption. Dimensionality can be tuned by varying the A-cation.
An iodide-containing covalent organic framework for enhanced radiotherapy
Authors: Zhou Le-Le , Guan Qun , Zhou Wei , Kan Jing-Lan , Dong Yu-Bin
Published: March 2023

An iodide-containing cationic covalent organic framework as a nonmetallic radiosensitizer increases X-ray deposition and enhances radiotherapy of colon cancer in vitro and in vivo by inducing ferroptosis.
Superior metal storage behavior of Zn-containing porous carbon nanostructures for Na and Li metal batteries
Authors: Kim Kyungbae , Jeon Seunghwan , Kim Han-Seul , Seo Hyungeun , Kim Hyun-seung , Doeff Marca M. , Woo Sang-Gil , Kim Jae-Hun
Published: March 2023

A Zn-containing porous carbon electrode enables Na metal storage over 2500 cycles by inducing a uniform current distribution for Na metal nucleation.
Electrochemical lithium doping of Cu2−xS nanocrystal assemblies for tuning their near infrared absorbance
Authors: Lee HanKyul , Jo Hyunwoo , Lee Jong Ik , Koirala Agni Raj , Cho Hwichan , Huh Wansoo , Kang Moon Sung
Published: March 2023

The characteristic NIR of copper sulfide nanocrystals (Cu2−xS NCs) assemblies based on the LSPR can be controlled by exploiting monovalent lithium ions through electrochemical methods.
Bio-inspired surface modification of MoS2 nanosheets with gallium phthalocyanine for brain-like synaptic memristors
Authors: Jiang Qizhi , Zhang Bin , Yan Qing , Fan Fei , Liu Gang , Chen Yu
Published: March 2023

Inspired by mussel chemistry, MoS2 nanosheets coated with polydopamine were covalently functionalized with gallium phthalocyanine. Biological synaptic functions and associative learning processes were successfully simulated by using memristors.
A Tb and Ag co-doped borate compound forms a high sensitive X-ray, gamma-ray and neutron luminescence dosimeter
Authors: França Leonardo V. S. , Müller Elisabeth , Yukihara Eduardo G. , Baffa Oswaldo
Published: March 2023

Thermal and optical stimulations of neutron-sensitive CaB6O10:Tb3+,Ag+ led to two recombination pathways.
Comparing Hearing Aid Outcomes in Adults Using Over-the-Counter and Hearing Care Professional Service Delivery Models
Authors: Swanepoel De Wet , Oosthuizen Ilze , Graham Marien Alet , Manchaiah Vinaya
Published: March 2023

Purpose:

More affordable hearing aids are now available due to over-the-counter (OTC) hearing aid regulations. Although laboratory studies have validated many OTC hearing technologies, there are limited real-world benefit studies. This study compared hearing aid outcomes reported by clients from OTC and conventional hearing care professional (HCP) service delivery models.

Method:

An ecological, cross-sectional survey design was employed. An online survey was sent to the Hearing Tracker user and OTC Lexie hearing aid user databases. Moreover, 656 hearing aid users completed the survey—406 through conventional HCP services (
M
age
= 66.7 ± 13.0 years) and 250 through the OTC model (
M
age
= 63.7 ± 12.2 years). Self-reported hearing aid benefit and satisfaction were measured with the International Outcome Inventory for Hearing Aids outcome tool.

Results:

No significant difference for overall hearing aid outcomes between HCP and OTC users was evident using regression analyses, controlling for age, gender, duration of hearing loss, duration before hearing aid purchase, self-reported hearing difficulty, and unilateral versus bilateral fitting. For the “daily use” domain, HCP clients reported significantly longer hours of daily use. For the “residual activity limitations” domain, OTC hearing aid users reported significantly less difficulty hearing in situations where they most wanted to hear better.

Conclusions:

OTC hearing aid outcomes could complement and provide similar satisfaction and benefit to HCP models for adults. Service delivery aspects such as self-fitting, acclimatization programs, remote support, behavioral incentivization, and payment options should be investigated for their potential role in OTC hearing aid outcomes.

Supplemental Material:

https://doi.org/10.23641/asha.22134788
Maximum Phonation Time as a Surrogate Marker for Airway Clearance Physiologic Capacity and Pulmonary Function in Individuals With Amyotrophic Lateral Sclerosis
Authors: Tabor Gray Lauren , Donohue Cara , Vasilopoulos Terrie , Wymer James P. , Plowman Emily K.
Published: March 2023

Purpose:

The increased use of telehealth practices has created a critical need for home-based surrogate markers for prognostic respiratory indicators of disease progression in persons with amyotrophic lateral sclerosis (pALS). Given that phonation relies on the respiratory subsystem of speech production, we aimed to examine the relationships between maximum phonation time (MPT), forced vital capacity, and peak cough flow and to determine the discriminant ability of MPT to detect forced vital capacity and peak cough flow impairments in pALS.

Method:

MPT, peak cough flow, forced vital capacity, and ALS Functional Rating Scale scores were obtained from 62 pALS (El-Escorial Revised) every 3 months as part of a longitudinal natural history study. Pearson's correlations, linear regressions, and receiver operator characteristic curve analyses with the area under the curve (AUC), sensitivity, specificity, and likelihood ratios were calculated.

Results:

The mean age of pALS was 63.14 ± 10.95 years, 49% were female, and 43% had bulbar onset. MPT predicted forced vital capacity,
F
(1, 225) = 117.96,
p
< .0001, and peak cough flow,
F
(1, 217) = 98.79,
p
< .0001. A significant interaction was noted between MPT and ALS Functional Rating Scale–Revised respiratory subscore for forced vital capacity,
F
(1, 222) = 6.7,
p
= .010, and peak cough flow,
F
(1, 215) = 4.37,
p
= .034. The discriminant ability of MPT was excellent for peak cough flow (AUC = 0.88) and acceptable for forced vital capacity (AUC = 0.78).

Conclusions:

MPT is a simple clinical test that can be measured via telehealth and represents a potential surrogate marker for important respiratory and airway clearance indices. Further larger studies are required to validate these findings with remote data collection.

Supplemental Material:

https://doi.org/10.23641/asha.22186408
Morphology of the gas-rich debris disk around HD 121617 with SPHERE observations in polarized light
Authors: Perrot Clément , Olofsson Johan , Kral Quentin , Thébault Philippe , Montesinos Matías , Kennedy Grant , Bayo Amelia , Iglesias Daniela , van Holstein Rob , Pinte Christophe
Published: March 2023

Context. Debris disks are the signposts of collisionally eroding planetesimal circumstellar belts, whose study can put important constraints on the structure of extrasolar planetary systems. The best constraints on the morphology of such disks are often obtained from spatially resolved observations in scattered light. In this paper, we investigate the young (~16 Myr) bright gas-rich debris disk around HD 121617.

Aims. We use new scattered light observations from VLT/SPHERE to characterize the morphology and the dust properties of the debris disk. From these properties, we can then derive constraints on the physical and dynamical environment of this system, for which significant amounts of gas have been detected.

Methods. The disk morphology is constrained by linear polarimetric observations in the J band. Based on our modeling results and archival photometry, we also model the spectral energy distribution (SED) to put constraints on the total dust mass and dust size distribution. Finally, we explore different scenarios that could explain these new constraints.

Results. We present the first resolved image in scattered light of the debris disk around HD 121617. We fit the morphology of the disk, finding a semi-major axis of 78.3 ± 0.2 au, an inclination of 43.1 ± 0.2°, and a position angle of the major axis with respect to north of 239.8 ± 0.3°, which is compatible with the previous continuum and CO detection with ALMA. Our analysis shows that the disk has a very sharp inner edge, possibly sculpted by a yet-undetected planet or gas drag. While less sharp, its outer edge is steeper than expected for an unperturbed disk, which could also be due to a planet or gas drag, but future observations probing the system farther from the main belt would help explore this possibility further. The SED analysis leads to a dust mass of 0.21 ± 0.02 M⊕ and a minimum grain size of 0.87 ± 0.12 μm, smaller than the blowout size by radiation pressure, which is not unexpected for very bright collisionally active disks.
The proto-neutron star inner crust in the liquid phase
Authors: Dinh Thi H. , Fantina A. F. , Gulminelli F.
Published: March 2023

Context. The crust of a neutron star is known to melt at a temperature that increases with increasing matter density, up to about 1010 K. At such high temperatures and beyond, the crustal ions are put into collective motion and the associated entropy contribution can affect both the thermodynamic properties and the composition of matter.

Aims. We studied the importance of this effect in different thermodynamic conditions relevant to the inner crust of the proto-neutron star, both at beta equilibrium and in the fixed-proton-fraction regime.

Methods. To this aim, we solved the hydrodynamic equations for an ion moving in an incompressible, irrotational, and non-viscous fluid, with different boundary conditions, thus leading to different prescriptions for the ion effective mass. We then employed a compressible liquid-drop approach in the one-component plasma approximation, including the renormalisation of the ion mass to account for the influence of the surrounding medium.

Results. We show that the cluster size is determined by the competition between the ion centre-of-mass motion and the interface properties, namely the Coulomb, surface, and curvature energies. In particular, including the translational free energy in the minimisation procedure can significantly reduce the optimal number of nucleons in the clusters and lead to an early dissolution of clusters in dense beta-equilibrated matter. On the other hand, we find that the impact of translational motion is reduced in scenarios where the proton fraction is assumed constant and is almost negligible on the inner-crust equation of state.

Conclusions. Our results show that the translational degrees of freedom affect the equilibrium composition of beta-equilibrated matter and the density and pressure of the crust-core transition in a non-negligible way, highlighting the importance of its inclusion when modelling the finite-temperature inner crust of the (proto-)neutron star.
Jet-induced molecular gas excitation and turbulence in the Teacup
Authors: Audibert A. , Ramos Almeida C. , García-Burillo S. , Combes F. , Bischetti M. , Meenakshi M. , Mukherjee D. , Bicknell G. , Wagner A. Y.
Published: March 2023

In order to investigate the impact of radio jets on the interstellar medium (ISM) of galaxies hosting active galactic nuclei (AGN), we present subarcsecond-resolution Atacama Large Millimeter/submillimeter Array (ALMA) CO(2-1) and CO(3-2) observations of the Teacup galaxy. This is a nearby (DL = 388 Mpc) radio-quiet type-2 quasar (QSO2) with a compact radio jet (Pjet ≈ 1043 erg s−1) that subtends a small angle from the molecular gas disc. Enhanced emission line widths perpendicular to the jet orientation have been reported for several nearby AGN for the ionised gas. For the molecular gas in the Teacup, not only do we find this enhancement in the velocity dispersion but also a higher brightness temperature ratio (T32/T21) perpendicular to the radio jet compared to the ratios found in the galaxy disc. Our results and the comparison with simulations suggest that the radio jet is compressing and accelerating the molecular gas, and driving a lateral outflow that shows enhanced velocity dispersion and higher gas excitation. These results provide further evidence that the coupling between the jet and the ISM is relevant to AGN feedback even in the case of radio-quiet galaxies.
Probabilistic representation of viscosity solutions to quasi-variational inequalities with non-local drivers
Authors: Perninge Magnus
Published: March 2023

We consider quasi-variational inequalities (QVIs) with general non-local drivers and related systems of reflected backward stochastic differential equations (BSDEs) in a Brownian filtration. We show existence and uniqueness of viscosity solutions to the QVIs by first considering the standard (local) setting and then applying a contraction argument. In addition, the contraction argument yields existence and uniqueness of solutions to the related systems of reflected BSDEs and extends the theory of probabilistic representations of PDEs in terms of BSDEs to our specific setting.
Study on Geographical Regression Analysis of Driving Factors of Land Spatial Planning for Urban Development
Authors: Chang Luqun , Bian Zhengfu
Published: March 2023

This paper integrates the factors of urban regulatory detailed planning, land use planning, whole life cycle of land resource management and project construction approval, unifies the spatial datum and constructs the Driving Factors System of the Land Spatial Planning (DFSLSP) through data fusion. Using the core idea of Spatial Information Multi-level Grid and according to the irregular grid architecture, the irregular multi-level grid level is associated with spatial control zoning and land use unit, and the Driving Factors Multi-level Grid of Land Spatial Planning (DFMGLSP) is simulated and established. On this basis, the concept, size and state of plot unit are redefined. Through the analysis results of Geographic Weighted Regression(GWR) examples, for the plots whose urban development status is seriously underestimated or overestimated, after superimposing the driving factors layers, analyze the spatial relationship between them and the plots with low reliability, so as to obtain the causes of errors, and screen out the land use planning permission and project planning permission as the driving factors affecting urban construction and development, and four factors, such as the “two regulations” conflict, approval but not supply, inefficiency and idle land, are the resistance factors affecting urban construction and development. All these provide new ideas and new methods for assisting the government in planning control and guiding urban development.