bluuebunny/crossref_metadata_2025 huggingface dataset:
Gel-ultraphonophoresis for patients with scarring on the skin: results of comparative prospective intervention study
Authors: Gritskova Inna A. , Ponomarenko Inga G. , Ponomarenko Gennadiy N. , Cherkashina Irina V.
Published: November 2023

INTRODUCTION. In modern realities of peace and military trauma there are an increasing number of scar skin defects, often accompanied by pronounced subjective sensations and tissue functional limitations. An urgent task is the scientific substantiation of effective methods of their correction.
OBJECTIVE. To determine healing effects and safety of using ultraphonophoresis of enzyme gel with high transcutaneous and proteolytic activity in patients with scarring on the skin.
MATERIALS AND METHODS. There was examination of 82 patients with emerging (N=21 study group, N=16 comparison group) and mature (N=25 study group, N=20 comparison group) scar skin of different localizations at the rehabilitation stage after various injuries, burns, removal of skin neoplasms. The study applied clinical and functional methods in the assessment of scar tissue, medical and sociological methods in evaluating patients’ quality of life and safety profile.
RESULTS. There were improved clinical indicators and functional skin properties in the scar area, a significant regression of subjective sensations, an increased quality of life score, more pronounced in the study groups. Dynamics of clinical indicators is more expressed in group 1 and group 3. Vascularization values before and after treatment in the groups were: in group 1 and 3 before treatment - 6,4±0,93 and 5,8±0,25, after - 3,0±0,24 and 2,7±0,31, respectively; in group 2 the values before and after treatment were 5,6±0,26 и 4,2±0,62, respectively, in group 4 – before treatment 4,9±0,53, after - 4,1±0,48. As a result of dynamics of the quality of life indicators, a more significant improvement was found in the study groups with respect to the comparison groups. In the group with emerging scars the sum of points before treatment was 20,4±0,3, after treatment - 12,4±0,3; in the comparison group - 18,7±0,5 and 13,4±0,5 before and after treatment, respectively; in the group with mature scars: before treatment - 23,6±0,3, after - 13,7±0,4; in the comparison group - 21,3±0,4 и 16,2±0,5 before and after treatment, respectively. A favorable safety profile of treatment was defined: adverse events (tingling, burning) were transient and fully cupped after the procedure.
DISCUSSION. Ultraphonophoresis, one of the man methods in the transdermal delivery, contributes to changing the epidermal barrier permeability for molecules of various drugs as well as potentiation for actions of anti-scarring agents at different stages of emerging and existing scar skin defects.
CONCLUSION. Ultraphonophoresis of the enzyme gel with a high transcutaneous and proteolytic activity has fibromodulating and sedative curative effects in patients with scarring skin of different genesis and duration.
The Phenomenon of the Japanese Main Banks, a Factor of High Competitiveness of Japanese Businesses
Authors: Mamytov U. E.
Published: November 2023

It is well known fact that the availability of credit is one of the most important factors of economic development. Particularly this factor is very problematic for Kyrgyz businesses as well as for businesses in some other EAEU countries. In this regard, the phenomenon of the Japanese main banks deserve specific attention as these banks historically played (and still playing) an important role in stimulating Japanese businesses making them highly competitive worldwide.
Tools for Implementing Strategies in the Context of Digital Transformation of Industrial Enterprises
Authors: Shabaeva S. V. , Shabaev A. I.
Published: November 2023

Under conditions of uncertainty caused by sanctions and geopolitical changes, the correct choice of both strategic development priorities and management tools for their implementation becomes important. Given the global trend towards digitalization and the growing supply from software developers, it is necessary to understand clearly, which software products and for what purposes can be used effectively at specific enterprises. The challenge here is that due to instability, sanctions pressure, and withdrawals of foreign software from the Russian market, enterprises are forced to change business and technological processes, and to look for new tools for implementing development strategies.

   The purpose of the article is to determine the basic principles for choosing strategic management tools and information technologies as elements of strategic management at enterprises in the context of digital transformation.

   The article shows that due to the ongoing digitalization of industrial enterprises any tools for implementing the strategies must be considered within the framework of an automated process management model. It can be based on various information technologies or platform solutions, depending on the coverage of enterprise business processes, and the readiness to adopt digital technologies in strategic and operational management. The modern trend is to implement strategic development directions, relying on the internal ecosystem of the enterprise. Making the right choice of information technology within an enterprise ecosystem requires that technology investments are aligned with the company’s business goals, adaptable to changing needs, can integrate with existing systems, are user-friendly, secure, and provide a short-term return on investment. Ultimately, these principles enable businesses to successfully navigate the digital transformation journey and leverage technology as a strategic enabler for sustainable growth.
A Monte Carlo Experiment on the Asymptotic Efficiency of System Estimators under Multicollinearity
Authors: ODUNTAN EMMANUEL
Published: November 2023

Classical linear regression model assumes that there is no multicollinearity among the explanatory variables in a regression model. Contrary to this assumption, where multicollinearity is perfect, the regression coefficients of the explanatory variables are indeterminable and their standard errors are infinite. On the other hand, where multicollinearity is less than perfect, the regression coefficients, although determinable, possess large standard errors. This implies that the coefficients cannot be estimated with great precision. Hence multicollinearity problem is a major problem in econometric analysis. Using Monte Carlo Simulation, we evaluated the asymptotic efficiency of six estimators (OLS, ILS,2SLS, 3SLS, LIML and FIML), under different magnitudes of the unintended linear relationship between the exogenous variables. Using the SSR criteria, we found that OLS followed by ILS turned out the best estimates amongst the six estimators under multicollinearity. We also found that with increasing sample size, there is no remarkable asymptotic effect in the performance of the estimators at the levels of multicollinearity.
Predicting Indonesia’s Gross Domestic Product (GDP): A Comparative Analysis of Regression and Machine Learning Models
Authors: Widjaja Christopher Kevin , Soo Huei Ching , Lawardi Bernadette Marini
Published: November 2023

This research paper presents an analysis of Indonesia's quarterly Gross Domestic Product (GDP) growth spanning a significant 13-year period, from the first quarter of 2010 to the fourth quarter of 2022. The study focuses on utilizing four key economic indicators to gain insights into the country's economic performance during this timeframe. To develop accurate predictive models, we utilize Multiple Linear Regression (MLR), K-Nearest Neighbours (K-NN), and Artificial Neural Network (ANN) approaches. The models are compared based on performance metrics, including the Mean Absolute Error (MAE) and the Root Mean Squared Error (RMSE). Our findings indicate that the MLR model outperforms the machine learning models, K-NN and ANN, in forecasting Indonesia's GDP. This suggests that a simpler and more explainable model, such as MLR, suffices to provide meaningful and interpretable results. The paper's insights are valuable to economists, policymakers, and researchers, offering a practical and understandable means to predict Indonesia's economic trajectory. Keywords: Artificial Neural Network (ANN), Gross Domestic Product (GDP), K-Nearest Neighbours (K-NN), Multiple Linear Regression (MLR), Predictive Models.
Two cases of extracorporeal membrane oxygenation for ventilator-dependent infants with bronchopulmonary dysplasia and pulmonary hypertension
Authors: Jeon Yong Hyuk , Jang Wonjin , Kwon Hye Won , Cho Sungkyu , Kwak Jae Gun , Lee In Kyung , Lee Kyeong Hun , Park June Dong , Lee Bongjin
Published: November 2023

Bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) are potentially fatal complications in prematurely born infants. Extracorporeal membrane oxygenation (ECMO) may be a life-saving option for managing infants with BPD and PH. We present 2 patients who were successfully weaned off mechanical ventilators (MVs) through the application of ECMO. The patients were transferred to our institution after receiving MV care for 8 and 10 months, respectively, for BPD and PH. We were able to remove the patients from MVs after a period of ECMO-mediated lung rest. Although more research is required to determine specific criteria for ECMO use in patients with BPD and PH, our clinical experiences may contribute to the early application of ECMO in MV-dependent patients.
Assessing measurement model of performance management in government agencies using SEM-PLS analysis
Authors: Noordiatmoko Didid , Anggriawan Tommy , Eka Saputra Aditya
Published: November 2023

The government has formed various formulations of national development objectives. The problem formulation has pushed the government to evaluate every existing work program. Performance assessment is carried out on various existing development on public sectors to optimize performance management. This paper explains the government performance measurement model using the structural equation modeling based on partial least squares (SEM-PLS) method. Measurement of performance management is based on three factors: 1) institutional dimension; 2) operational dimensions; 3) value-added dimension (Alawaqleh, 2021; Kasannudin, 2021; Muizu & Sari, 2019). This research was conducted by distributing questionnaires to local governments in Yogyakarta, West Java, and South Sumatra. As a result of this study, the significant impact of operational measurement, value-added measurement and institutional policy on improving the performance of the organization was confirmed. The study found that the first factor in establishing sustainable performance management is the operational dimension which is one of the keys to sustainable performance management through government evaluation systems. This study is expected to be an important input for policymakers and practitioners in the development and implementation of sound and sustainable performance management systems.
SUCCESSFUL RAPID LIPOSOMAL AMPHOTERICIN-B DESENSITIZATION IN PEDIATRIC CASE SERIES AND LITERATURE REVIEW
Authors: Misirlioglu Emine , Geniş Cankat , emeksiz zeynep sengul , yaytokgil şule büyük , Ginis Tayfur , ISLAMOGLU Candan
Published: November 2023

Background: Amphotericin B is the broadest-spectrum polyene
group antifungal agent. In the presence of an infection caused by a
fungal agent resistant to alternative antifungal drugs, desensitization
may be the only option to continue treatment. However, there is
insufficient information and consensus regarding Amphotericin B
desensitization protocols in the pediatric age group.
Objective: In this study, we present our experience with five
cases where successful desensitization protocols were applied with
Liposomal Amphotericin B (AmBisome®; LAMB), along with a review of the
literature on pediatric cases. We also provide a sample desensitization
protocol that we successfully applied. Methods: In this
retrospective study, pediatric patients who continued their treatment
with the successful rapid desensitization protocol conducted at the
Pediatric Allergy and Immunology Clinic of the Ministry of Health Ankara
City Hospital between September 2019 and September 2023 were examined.
In our study, desensitization protocols were applied based on Castell et
al.’s desensitization protocol. Results: Between 2019 and 2023,
five patients aged between 5 and 12 years, including three with
hematologic malignancies, one with tuberculosis meningitis, and one with
chronic granulomatous disease, were referred to us due to the
development of anaphylaxis during their treatment with LAMB. Anaphylaxis
is diagnosed clinically, considering the European Academy of Allergy and
Clinical Immunology (EAACI). A 16-step desensitization protocol was
prepared using LAMB solutions at four different dilutions (0.001 mg/ml,
0.01 mg/ml, 0.1 mg/ml, 1 mg/ml). Each solution consisted of four steps
with a 15-minute infusion for each step. Patients was premedicated with
1 mg/kg/dose methylprednisolone and an antihistamine.
Conclusion: The data we present on the successful application
of a sample protocol to five cases, particularly in a pediatric setting,
is a significant and valuable contribution to the field. This can
provide important insights and potentially serve as a reference for
medical professionals working with similar cases in the future.
Nonlinear Extended State Observer-based Sliding Mode Control Strategy of PMSM against Disturbances
Authors: Z NN , Wang Qiming , Jiang Changhong
Published: November 2023

This paper presents a nonlinear extended state observer-based
sliding mode control strategy of Permanent magnet synchronous motor
(PMSM) to address the poor performance of conventional double
closed-loop PI control under tough conditions.
A variable speed
reaching law is proposed to balance the rapidity and robustness under
the fixed parameters of the
exponential reaching law. Then, a
nonlinear extended observer is proposed to ensure the estimated accuracy
of disturbance and rotational speed. Then, a deadbeat current prediction
control is designed to replace the conventional dual PI current control
to ensure efficient current loop control of PMSM. Furthermore, the
stability proof of the proposed control strategy is developed.
Experimental results are given to validate the effectiveness of the
proposed control strategy.
The proposed control approach can
effectively improve speed and current control performance with tough
conditions (e.g., speed and torque step-changes, periodic
disturbances).
Age, not Autism, Influences Multisensory Integration of Speech Stimuli among Adults
Authors: III Robert M. Jertberg , Begeer Sander , Geurts Hilde , Chakrabarti Bhismadev , Burg Erik van der
Published: November 2023

Differences between autistic and non-autistic individuals in perception
of the temporal relationships between sights and sounds are theorized to
underlie difficulties in integrating relevant sensory information.
These, in turn, are thought to contribute to problems with speech
perception and higher level social behaviors. However, the literature
establishing this connection often involves limited sample sizes and
focuses almost entirely on children. To determine whether these
differences persist into adulthood, we compared 469 autistic and 373
non-autistic adults (aged 17 to 75 years). Participants completed an
online version of the McGurk/MacDonald paradigm, a multisensory illusion
indicative of the ability to integrate audiovisual speech stimuli.
Audiovisual asynchrony was manipulated, and participants responded both
to the syllable they perceived (revealing their susceptibility to the
illusion) and to whether or not the audio and video were synchronized
(allowing insight into temporal processing). In contrast with prior
research with smaller, younger samples, we detected no evidence of
impaired temporal or multisensory processing in autistic adults.
Instead, we found that in both groups, multisensory integration
correlated strongly with age. This contradicts prior presumptions that
differences in multisensory perception persist and even increase in
magnitude over the lifespan of autistic individuals. It also suggests
that the compensatory role multisensory integration may play as the
individual senses decline with age is intact. These findings challenge
existing theories and provide an optimistic perspective on autistic
development. They also underline the importance of expanding autism
research to better reflect the age range of the autistic population.
Transcranial Magnetic Stimulation in the Assessment of Acupuncture Effect on Exercise-Induced Fatigue
Authors: hu linghui , Wei Zhen , Wang Xiaolei , wu wei
Published: November 2023

This study aims to evaluate the acupuncture effect on exercise-induced
fatigue utilizing transcranial magnetic stimulation (TMS). A total of 20
sports enthusiasts were recruited in this study, all participants would
be assigned to receive acupuncture and sham acupuncture intervention on
exercise-induced fatigue randomly. TMS and heart rate monitor would be
used to measure the amplitude and latency of motor evoked potential
(MEP) and heart rate every 5 minutes over a 30-minute period. Lactate
Scout+ was used to measure the blood lactic acid (BLA) in baseline, 0
minutes and 30 minutes after fatigue. Two-way repeated measures ANOVA
was used to compare the difference between acupuncture method and time
effects. Bonferroni post hoc tests were conducted to compare specific
differences. Significance was set at P < 0.05. Interaction
effect was found between acupuncture method and time effect in amplitude
(F (1, 38) = 5.40, P < 0.001, η2 = 0.12) and latency (F (1,
38) = 3.78, P = 0.008, η2 = 0.09) of MEP. Acupuncture intervention can
promote the recovery of heart rate especially at 30 minutes (P
< 0.05), but which seem insufficient to generate significant
difference in BLA (F (1, 38) = 0.067, P = 0.797, η2 = 0.002).
Preliminary findings provide new perspectives for sports enthusiasts to
relieve fatigue and reduce the inhibition of motor cortex excitability
utilizing acupuncture.
Spatial variation analysis of the effect of wheat and maize crop rotation on soil organic carbon in the Sushui River Basin
Authors: Jing Yingqiang , Bi Rutian , Sun Weifeng , zhu hongfen , Ding Haoxi
Published: November 2023

Objective of investigation: Enhancing soil organic carbon (SOC)
content in farmland is crucial for soil quality maintenance and food
security. Crop rotation plays a significant role in this regard.
However, the relationship between crop rotation and SOC sequestration
remains unclear. This study focused on the effects of wheat
−maize crop rotation on SOC in the Sushui River Basin in
2017–2021. Experimental material: soil organic carbon (SOC)
content of monoculture wheat (47), monoculture maize (30), and
wheat-maize rotation (35) sites in 2017 and 2021 cropland quality
monitoring sites. Influencing factors were average temperature and
rainfall during the study period, topographic factors, soil factors, and
anthropogenic factors dominated by cropping systems. Method of
investigation: Geographically Weighted Regression and Geodetector were
used to explore the spatial effects of major food cropping systems on
SOC trends and their interactions with other factors. Data
collection: Soil, climate, and terrain data were obtained from Shanxi
Province Cropland Quality Monitoring Data, Yuncheng Meteorological
Bureau, and the Geospatial Data Cloud website of the Computer Network
Information Center of the Chinese Academy of Sciences, respectively.
Results: Analysis of variance (ANOVA) indicated significant
differences only between wheat and maize monocrops. Altitude,
temperature, rainfall, and pH were the main factors affecting SOC
spatial heterogeneity. Although the impact of the cropping system alone
on spatial heterogeneity was not significant, the influence increased
after interactions with other factors. Concerning SOC variation,
wheat–maize rotation had a trade-off effect with elevation and
synergistic effects with rainfall and pH. It displayed a synergistic
effect with temperature in the southwest and a trade-off effect in the
northeast. Conclusions: The degrees of trade-offs and synergy
varied spatially among all interacting factors. Our results provide
valuable insights that could facilitate optimization of planting layout
and improvement of farmland management schemes.
Novel Recognition Method for the Locale of Membrane Proteins by Employing Deep Learning Algorithm
Authors: Faiz Mehwish , Khan Saad Jawaid , Azim Fahad , Ejaz Nazia , Shamim Fahad
Published: November 2023

Membrane proteins are those biomolecules that are attached to or
incorporated into the membranes of cells and their organelles. Depending
on their functions, they are located in various regions of a cell and
are essential to several cellular processes. The locale revelation of
these biomolecules is critical as it portrays their activities. Most
protein subcellular localization predictors have been trained
particularly on globular type and perform poorly on those residing on
membranes, specifically through Deep Learning. To overcome this issue,
membrane proteins are forecasted in three distinct locations, (a) plasma
membrane, (b) internal membrane, and (c) organelle membrane. Features
are extracted through Pseudo Amino Acid Composition and some other
features from a redundancy curtailed MemLoci dataset. Pseudo Amino Acid
Composition is an illustrious approach that excerpts factual protein
information through amino acid sequences. Another key feature is that
the Pseudo Amino Acid Composition’s impact is unrelated to the Deep
Learning Execution of these membrane proteins. This novel study employs
four deep learning models, including (a) Artificial Neural Networks
(ANN), (b) Recurrent neural networks (RNN), (c) Convolutional neural
networks (CNN), and (c) Long Short Term Memory (LSTM). After extensive
experimentation, the accuracy of yields is 83.2%, 83.4%, 82.4%., and
80.5% respectively. The outcomes indicate that the simple RNN and ANN
models, which are less used in the research, are more suitable compared
to the other two models CNN and LSTM which are frequently implemented
models in proteomics. The results of the first two models is
approximately similar, with a difference of 0.2% among each other,
however, they surpass the other two models with better of outcomes in
the range of 2 - 3%.
Generalising Tree-Level Sap Flow Across the European Continent
Authors: Loritz Ralf , Wu Chen Huan , Klotz Daniel , Gauch Martin , Kratzert Frederik , Bassiouni Maoya
Published: November 2023

Sap flow observations provide a basis for estimating transpiration and
understanding forest water use dynamics and plant-climate interactions.
This study developed a continental modeling approach using Long
Short-Term Memory networks (LSTMs) to predict hourly tree-level sap flow
across Europe based on the SAPFLUXNET database. We developed models with
varying levels of training sets to evaluate performance in unseen
conditions. The average Kling-Gupta Efficiency was 0.77 for gauged
models trained on 50 % of time series across all forest stands and was
0.52 for ungauged models trained on 50 % of the forest stands.
Continental models matched or exceeded performance of specialized and
baseline models for all genera and forest stands, demonstrating the
potential of LSTMs to generalize hourly sap flow across tree, climate,
and forest types. This work highlights hence the potential of deep
learning models to generalize sap flow for enhancing tree to continental
ecohydrological investigations.
Croup in children in the period of the COVID-19 pandemic
Authors: Stroganova M. A. , Martynova G. P. , Bogvilene Ya. A. , Elmina K. O. , Ikkes L. A. , Evreimova S. V. , Belkina A. B.
Published: November 2023

Croup syndrome remains one of the most common diseases in children, while being a life-threatening condition for the patient. Materials and methods. The paper presents the clinical and epidemiological features of croup in 79 children aged 0 months. up to 5 years of age hospitalized during the COVID-19 pandemic from January to September 2022. Results. In the age structure of patients, children of the first year of life predominated. The clinical picture of croup against the background of COVID-19 was usually characterized by an acute onset, febrile fever with the addition of symptoms of stenosing laryngotracheitis on the second and third days from the onset of the disease. The appointment of timely and adequate therapy at all stages of care is the key to a favorable outcome of croup in children.
Clinical and laboratory aspects of the new coronavirus infection in newborns and infants
Authors: Ermakova M. K. , Najdyonkina S. N. , Matveeva L. P.
Published: November 2023

Purpose: to identify clinical and laboratory aspects of a new coronavirus infection in newborns and infants. Materials and methods: a retrospective analysis of 131 observations of newborns and infants infected with SARS-CoV-2 treated in children's infectious diseases departments of Izhevsk was carried out. Results. The course of coronavirus infection in newborns and infants who became ill on an outpatient basis and were hospitalized did not have significant specific clinical and laboratory features and was similar to the symptoms of major respiratory infections. Among the hospitalized, 80.9% of children had a mild severity of coronavirus infection, the rest of the children had a moderate course. The clinical picture was dominated by cough (86.3%), nasal congestion (74%) and fever (71.8%). Significant clinical differences were obtained in newborns in the form of predominance of nasal obstruction, and in infants in the predominance of fever and dry cough. Pneumonia was diagnosed in 19.1% in the form of a mild, mainly bilateral lesion.
The nature of lesions of the central nervous system in infections, caused by Varicella Zoster virus
Authors: Eshmolov S. N. , Klimovitskaya E. G. , Kuzmina M. N. , Sitnikov I. G.
Published: November 2023

Varicella Zoster virus can cause damage to the nervous system, more often in the form of meningitis and meningoencephalitis.

Purpose: to identify the nature of damage to the central nervous system during infections caused by the Varicella Zoster virus. Materials and methods. The article presents the literature data and the results of own observations of 47 patients treated at the Infectious Diseases Clinical Hospital of Yaroslavl in the period from 2015 to 2021. There were 20 children (42.6%) aged from 18 days to 12 years with chickenpox. There were 27 (57.4%) patients with Herpes Zoster, of which 20 (74.1%) were adults aged 24 to 82 years, 7 (25.9%) were children aged 4 to 14 years. Results. The main clinical and laboratory indicators were analyzed, the features of central nervous system lesions caused by the Varicella Zoster virus were revealed, and the medical and social significance of this problem was confirmed. Among the patients, patients with Herpes Zoster predominated — 27 (57.4%). Meningitis (45.0%), meningoencephalitis (30.0%) and encephalitis (25.0%) were recorded in children with chickenpox. In children with Herpes Zoster, meningoencephalitis predominated (71.4%), while in adults - meningitis (65.0%); there were no encephalitis. There were no deaths, 14.9% of patients were transferred to the neurological department, 85.1% were discharged as outpatients.
Experience of using inhaled steroid therapy in children with whooping cough
Authors: Popova O. P. , Shvetsova Yu. V. , Bunin S. V. , Fedorova I. M. , Koteleva S. I. , Grechishnikova O. G.
Published: November 2023

The aim of study: аnalysis of the effectiveness of inhaled steroid therapy in patients with whooping cough.

Materials and methods: 74 patients with whooping cough were observed, among whom 40 children included inhalations with Budesonide in complex therapy (main group). 34 patients in the comparison group received only basic therapy. The age structure in the main group was as follow: тhere were children under one years old 18 (47.4 ± 8.1%), 1—3 years — 7 (18.4 ± 6.3%); 4—6 years — 8 (21 ± 6.6%), 7—14 years — 7 (13.2 ± 5.5%) and comparable to the comparison group. To verify whooping cough were used the PCR method and serological diagnostic (IFA) using a test system “Ridascreen/Bordetella pertussis («R-biofarm AMG», Germany). Results: budеsonide was prescribed for a course of 5—7 days. Clinical analysis of dynamics of cough in main group showed, that a reduction in a number of attacks by the 4—5th day of budesonide was observed in majority of children (35/87.5 ± 5.2%). In the main group coughing attacks with a frequency of more than 15—25 times a day persisted for 2.7 ± 0.2 days, and in comparison group — 4.3 ± 0.2 (p < 0.001). Relief of broncho-obstructive syndrome was observed in shorter period of time, which contributes to a reduction in the average length of stay of the patient in the hospital.
Evolution of Haemophilus influenzae infection during the vaccination period: literature review
Authors: Krasivskiy A. V. , Kovalev O. B. , Borisova O. Yu. , Shamsheva O. V. , Krasivskaya A. V. , Molochkova O. V. , Turina I. Е.
Published: November 2023

Mass immunization with H. influenzae type b (Hib) vaccines has led to a sharp decrease in the incidence of invasive and non-invasive forms of Haemophilus influenza infection. H. influenzae causes a diverse spectrum of diseases from usually asymptomatic carriage to otitis, sinusitis, epiglottitis, pneumonia, endopericarditis, inflammation of the subcutaneous tissue, arthritis, and is one of the four main causative agents of bacterial meningitis. Materials and methods. In order to identify the significance of Hemophilus influenzae infection during the vaccination period, an analysis was carried out on the spread of Hemophilus influenzae infection, its clinical forms, as well as the antibiotic resistance of the pathogen. A review of domestic and foreign publications over the past 20 years was conducted in the search engines PubMed, Google Scholar, Cochrane Library and Elibrary. Results. Studies conducted in various countries show that after the start of mass immunization, H. influenzae type b is no longer the dominant serotype of the pathogen causing invasive infections in most countries. Everywhere in the world, the leading positions are occupied by cases of infection caused by non-typable serotypes of H. influenzae type a, f, b (Hia, Hif, Hib) predominate among the capsular forms. Unprotected aminopenicillins, second-generation cephalosporins, and sulfonamides are the leading classes of antibacterial drugs to which H. influenzae strains have developed resistance. A variety of clinical forms is still relevant for hemophilic infection. Bacteremia, meningitis, and pneumonia are the main clinical manifestations of invasive Haemophilus influenzae infection caused by typed and non-typed serotypes of the pathogen.
Kawasaki syndrome in a young child: clinical case
Authors: Sokolovskaya V. V. , Litvinova A. A. , Krikova A. V. , Kozlov R. S.
Published: November 2023

Kawasaki syndrome (SC) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that are difficult for doctors to diagnose and treat. These are two different states, despite the fact that many of their features have common features. Complex pathogenetic mechanisms that cause the development of SC find their clinical expression in the defeat of a large number of functional systems of the body. The aim: demonstrating the difficulty of diagnosing Kawasaki syndrome in a young child of 8 months. Results. The emphasis is placed on the clinical predominance of intoxication-febrile, respiratory, intestinal, exanthemic syndromes, as well as on the absence of specific symptoms from the cardiovascular system in the early stages of the disease, which made early diagnosis difficult. Conclusion. The clinical case we have presented demonstrates the atypical development of Kawasaki syndrome with a prolonged absence of changes from the cardiovascular system
Development of low carbon and energy-efficient geopolymer-based paving blocks
Authors: Jelic Ivana , Savic Aleksandar , Miljojcic Tatjana , Sljivic-Ivanovic Marija , Dimovic Slavko , Jankovic Marija , Perovic Ivana , Zakic Dimitrije , Antonijevic Dragi
Published: November 2023

The development of energy-efficient and low-carbon geopolymer-based paving
blocks made from waste, as an environmental-friendly material, was
evaluated. Ground concrete (GC) and solid brick (SB) powder, as the
representatives of construction and demolition waste (C&DW), with the
addition of fly ash (FA) and silica fume (SF), were used. Waste samples were
characterized in terms of surface functional groups and radioactivity. The
FT-IR spectra showed the required amorphous or semi-crystalline
alumino-silicate structure. The gamma spectrometry confirmed waste samples'
radiological safety. Hardened geopolymer samples were subjected to
physical-mechanical investigation comprising of density, water content,
compressive and flexural strengths determination. Based on strength
characteristics, the three best prototype mixtures were selected and
subjected to further compressive strength determination and durability
assessment. Prototype sample SBFASFp1, with a compressive strength of 18.7
MPa, was shown the highest value of all samples, almost the same as the
corresponding SBFASF1 sample. Freeze-thaw and the subsequent carbonation
tests, as durability indicators, showed that the SBFASF1 sample had the
slightest strength decrease, making it most durable in these conditions.
These satisfactory test results showed the favorable effects of alternatives
to cementitious materials, encouraging their utilization and contributing to
the sustainability of the construction sector.
The influence of alumina type on the immobilization of Ascorbate oxidase and ascorbic acid detection
Authors: Ramadani Barbara , Novakovic Sonja , Mojovic Milos , Mojovic Zorica
Published: November 2023

Two alumina types (trihydrate (T) and anhydrous (G)) were used for the
immobilization of ascorbate oxidase (AO) by the adsorption procedure. The
samples were characterized by FTIR analysis and EPR spectroscopy to confirm
the presence of enzyme in the composite and the activity of immobilized
enzyme. The samples of alumina with and without AO were used as modifer of
carbon paste electrode and tested by Fe(CN6)3-/4-redox probe using cyclic
voltammetry at different scan rates. The response of investigated electrodes
toward ascorbic acid was tested in the Britton-Robinson buffer at pH range
of 2 to 5. Direct detection of ascorbic acid was tested at G and G+AO
electrodes and the calibration curves were constructed by square wave
voltammetry under the optimized conditions. The immobilization of AO at
anhydrous alumina increased the concentration range and the sensitivity from
0.00617 ?M/?A for G to 0.01693 ?M/?A for G+AO in the concentration range
from 10 ?M to 200 ?M.
Palmar Basal Cell Carcinoma in Darker Skin Tone Patient: A Case Study
Authors: Alghamdi Nada , Algamdi Bader , Alsaati Ahmed A. , Al Nemer Areej M.
Published: November 2023

Abstract is missing (Short communication)
Antibacterial effect of periodic structure formed on SUS430 by using nanosecond pulsed laser
Authors: Okazaki Mikuru , Hashida Masaki , Iwamori Satoru
Published: November 2023

We investigated the laser-induced periodic surface structures (LIPSSs) formed on an SUS430 surface by irradiation with a nanosecond pulsed laser (Nd:YAG, wavelength of 532 nm, pulse width of 10 ns, number of pulses of 50, repetition rate of 10 Hz, and laser fluence of 1.2 J/cm2) and the antibacterial effect of the surface. LIPSSs with an interspacing of about 500 nm, which was close to the laser wavelength, were produced on the surface when the pulsed laser was near the ablation threshold. The film attachment method (JIS Z 2801) was used to measure the bacterial growth suppression on SUS430 surfaces with and without LIPSSs. On the surface without an LIPSS, the number of colonies was 1244, and on that with an LIPSS, the number was 198, indicating that the LIPSS formed by nanosecond pulsed laser irradiation inhibited the growth of bacteria. The chrome oxide layer on the SUS430 surface with the LIPSS may emit chrome ions from the edge of the LIPSS, enhancing the antibacterial effect.
NeuroD2/6 regulate expression balance of transcription factors controlling neurocortical cytoarchitecture
Authors: Kondakova Elena V. , Gavrish Maria S. , Tarabykin Viktor S. , Yan Kuo
Published: November 2023

BACKGROUND: Genes of the NeuroD family, including NeuroD1, NeuroD2, and NeuroD6, control neuronal survival, differentiation, maturation, and neurite specification in the nervous system. Deletion of NeuroD1 in the mouse brain results in complete loss of dentate gyrus because of neuronal apoptosis. NeuroD2 is required for neuron survival in the cerebellum and integration of thalamo-cortical connections into neocortex and formation of somatosensory whisker barrel cortex. In NeuroD2/6 double deficient (DKO) mice, callosal axon projections are defective due to abnormal EfnA4 signaling. In order to investigate the NeuroD2/6 controlled molecular cascade, we explored the expression of key transcription factors that control various aspects of cortical development in brains of NeuroD2 and NeuroD6 deficient mutants.
AIM: To investigate possible changes in differentiation programs downstream of NeuroD2/6 transcription factors.
METHODS: Embryos with NeuroD2/6 double deficiency were used in the experiments, and pregnant mice carrying E13.5 embryos were operated for in utero electroporation. We performed in situ hybridization at various stages of embryonic development to study the expression pattern of target genes. Analyzing the activity of a gene promoter, genomic DNA fragments containing NeuroD2/6 motifs were cloned into pMCS-Gaussia Luc vector for luciferase assays. Charts were made with GraphPad Prism software and data were presented as mean ± standard error.
RESULTS: Our findings showed that NeuroD1 expression is ectopically upregulated in postmitotic neurons of NeuroD2/6 DKO neocortex and hippocampus. We detected changes in expression of key transcription factors, Cux1, Tbr1, Lhx2, and Id2. Additionally, Cux1 was shown to be direct target of NeuroD2/6. Moreover, Olig2+ progenitors were increased in NeuroD2/6 DKO neocortex and expression of NeuroD2/6 and Olig2 was mutually exclusive. Thus, NeuroD2/6 regulates the expression of transcription factors in the developing brain.
CONCLUSION: Our findings indicate that cumulative action of NeuroD2 and NeuroD6 is required to initiate and maintain the expression of transcription factors Cux1, Tbr1, Lhx2, and Id2. Additionally, both genes are required to prevent premature differentiation of Olig2 positive glial precursors.
TEST RESULTS OF REINFORCED CONCRETE CROSS-RIBBED MODEL OF SPAN STRUCTURE OF THE BRIDGE AND THEIR ANALYSIS
Authors:   Lviv Polytechnic National University, Department of Highways and Bridges, Yao Xin , Kvasha Victor ,   Lviv Polytechnic National University, Department of Highways and Bridges
Published: November 2023

Presentation of samples of basic experimental data from research of spatial work of large-scale (scale 1: 4) reinforced concrete model of cross-ribbed span structure of the bridge and separate beams similar in structure to model beams, as well as methodological features and results of their analysis. During the tests, the model and separate (reference) beams were loaded with concentrated force, alternately at the intersections of the longitudinal and transverse ribs of the model. Deflections in the same nodes and support reactions of longitudinal beams were measured. A new methodological feature of this research was the determination of experimental bending moments in the model beams by direct comparison of the deflections of the model beams with similar deflections of separate (reference) beams. Depending on the location of the external load and the stiffness ratio, the load on the beams of the model is different. Taking into account an elastic-plastic stage of their work, the method of calculation of the maximum bending moments in the most loaded beams is offered in this paper.
MONTE CARLO METHODS: A FEATURES REVIEW IN TERMS OF USE FOR ASSESSING THE RELIABILITY OF RC STRUCTURES
Authors:   Lviv Polytechnic National University, Department of Building Constructions and Bridges, Tytarenko Roman , Khmil Roman ,   Lviv Polytechnic National University, Department of Building Constructions and Bridges
Published: November 2023

Recently, the optimization issue relevance of reinforced concrete (RC) structures design solutions through the maximum use of their bearing capacity resource has increased significantly; in turn, solving this issue depends on a fundamental understanding of the reliability and durability concepts. Because any loads, impacts, or bearing capacity reserve parameters are random variables, there is a need to build stochastic models, which can become the “reliability design” concept base shortly. Among other things, this review article is devoted to the Monte Carlo methods features analysis in terms of their use in the RC members’ reliability assessment tasks. Based on a modern literary sources review, recommendations for further studies of the RC structures’ reliability and durability (including damaged ones) under the conditions of the combined action of loads and a corrosive environment (using Monte Carlo methods) were also formulated.
PRACTICAL APPROACH TO THE RISK ANALYSIS OF CONSTRUCTION PROJECTS
Authors:   Warsaw University of Technology, Faculty of Civil Engineering, Walasek Dariusz
Published: November 2023

A construction risk assessment is the calculated process of identifying project specific threats on a jobsite, then analysing and evaluating each risk factor to determine the likelihood, impact, and repercussions of each of those variables. That assessment creates awareness surrounding the risks/hazards identified, assess current risk prevention measures that are in-place to determine if they are sufficient or if further action needs to be taken, ensuring that any legal requirements or contract requirements are being met regarding risk and also deciding if additional controls need to be implemented or if changes need to be made to construction risk management strategy.
An Integrated Engine Control Unit for a Spark Ignited Internal Combustion Engine
Authors: Zibani Ishmael , Tsamaase Kelebaone , Matlotse Edwin , Ngebani Ibo
Published: November 2023

A stepping valve system has been proposed before and proved to be feasible. The stepping valve move perpendicular to the piston, thereby avoiding piston-valve collisions associated with interference engines. In this study, the proposed Stepping Valve Control Unit, SVCU, was integrated with the conventional Engine Control Unit, ECU, of a simple SI engine. The resulting Integrated Engine Control Unit, IECU, as it is called, simplified the design of the ECU. The integration involved combining the basic fuel injector and sparking controls with the SVCU. The camshaft and crankshaft sensors were replaced by a Piston Direction Sensor, PDS. The PDS is an optical sensor, which works in conjunction with a gray coded trigger wheel to relay information to the IECU. The IECU was simulated using Quartus II design software. The hardware implementation of the IECU was done using EPM7128SL FPGA contained within the UP1 Altera Development Board. The behavior of the IECU was expected.
Pengaruh Kualitas Pelayanan terhadap Kepuasan Pasien pada Instalansi Farmasi Rawat Jalan RSI Ibnu Sina Simpang Empat
Authors: Defni Yustri , Assyahri Wahib , Ningsih Yulia
Published: November 2023

Ibnu Sina Islamic Hospital Simpang Empat West Pasaman is a type C private hospital that continues to progress, marked by an increase in the number of patient visits each year. The services at RSI Ibnu Sina Simpang Empat are known for the friendliness of the services provided. However, it is not uncommon for patients to complain about the lack of maximum service, one of which is in the Pharmacy Installation. This can be seen from the number of patients queuing in the Pharmacy Installation waiting room. This method uses quantitative research methods with the type of explanatory research that analyzes the relationships between a variable and other variables and tests the hypotheses that have been formulated. The population in this study were outpatients with an average monthly number of 4,886 patients obtained from the prescription record book at the Pharmacy Installation. The sample used in this study was 370 based on the Slovin Formula with a tolerance level of 5%. Sampling using simple random sampling technique.The results showed that there was a partial significant effect between tangible and patient satisfaction by 22.9%; reliability to patient satisfaction by 30.2%; empathy for patient satisfaction by 42.9%; responsiveness to patient satisfaction by 48.5%; assurance of patient satisfaction of 56.7%. And there is a stimulating influence of the five independent variables on patient satisfaction by 62.6%.
Peran Pemerintah Desa dalam Mengelola Sanitasi Lingkungan Guna Mewujudkan Kesejahteraan Masyarakat Desa Perkebunan Bukit Lawang
Authors: Tarigan Edgina Rosselin Br , Madya Efi Brata
Published: November 2023

This research aims to find out the role of the village government in managing environmental sanitation in order to realize the welfare of the people of Bukit Lawang plantation village. The method used is descriptive qualitative. Village government informants as many as 5 people. Location of Bukit Lawang Plantation Village. The research was conducted for 10 days, namely from June 22 to July 02, 2023 with data collection techniques with observation, interviews and documentation and the data source is divided into two, namely primary data from informants and then analyzed using analysis techniques with four processes, namely data collection, data reduction, data display and data verification Then tested data validity by using Triangulation of sources, techniques and time. The results of this study explain that the activities spearheaded by the village government towards the village community are very good and have progressed. This is evident from the people of Bukit Lawang Government Village who can enjoy a clean, healthy and safe environment. Good sanitation contributes significantly to people's health, comfort and quality of life. With this this activity can be declared a success and the awareness of the Bukit Lawang Plantation Village community is increasing until now. In conclusion, the government plays an important role in the empowerment and welfare of the Bukit Lawang village community.
Pertunjukan Tari Piring Kumun Sebagai Representasi Sosiologi Gender dan Upaya Pelestarian Adat Budaya Kerinci
Authors: Precillia Monita
Published: November 2023

Piring Kumun Dance is one of the traditional arts of the Kumun people. The Piring Kumun Dance is often performed in community activities and traditional activities, the dancers are a mixture of male dancers and female dancers. This research has three objectives namely; First, knowing the form of the motion of the Piring Kumun dance. secondly knowing the traditional and societal views of female dancers, thirdly analyzing the position and existence (social) of women in the Kumun community. This study uses Lev Vygotsky's feminist and sociocultural theory. Sociocultural theory emphasizes the role of social interaction in a person's psychological development. The research method used is a qualitative method with a content analysis approach from Krippendorf, namely a method used to examine symbolic phenomena with the aim of exploring and expressing the observed phenomena which are the content, meaning and essential elements of the performance. On the other hand, this research also uses an ethnographic context, this is done because it has compatibility between the subjects studied, namely art and culture or traditions in a society based on local wisdom.