bluuebunny/crossref_metadata_2025 huggingface dataset:
Port Efficiency Evaluation of Turkish Container Ports Based on DEA-SCOR Model: An Effective Sea Gateways in Türkiye for One Belt and One Road Initiative
Authors: BAŞTUĞ Sedat
Published: March 2023

This study aims to investigate the relative operational efficiency of major Turkish container ports based on the Data Envelopment Analysis - Supply Chain Operations Reference (DEA-SCOR) model. While Turkish export and import figures are growing, the scientifical studies on operational efficiency of Turkish ports are gaining more attention day by day. Of course, one of the important import countries is China for Türkiye and BRI (One Belt and One Road Initiative) tends to support Turkish trade between western and eastern countries. Therefore, Turkish ports’ efficiencies should be identified and suggestions have been presented for further development. The sampling frame was chosen from the members of TURKLIM and therefore, the SCOR and Data Envelopment Methodology examined 23 seaports. Both methodologies are generally used for analyzing the operational efficiency of ship inward-outward and stackings. The findings of the study show that four major ports are the most efficient gateways to handle inward and outward container traffic with their input variables. However, there are some challenges in port investment for BRI. This study should be used for the further analysis in the sector reports and scientific papers.
PENANAMAN EMBRIO PADA RAHIM ISTRI YANG LAIN
Authors: Junaidi Najib , Syafi'ie Ahmad Musta'in
Published: March 2023

This paper discusses the practice of IVF (in vitro fertilization) by another wife's womb. This practice was declared haram by the fatwa of the Indonesian Ulama Council on June 1979. The reason is it will cause complexity in matters of inheritance. Especially, between child and owner of the ovum and surrogate mother. This research is a qualitative research with normative juridical approach. This research is a library research. This research use documentation techniques. This study concluded that the complexity in the inheritance problem that is feared in the MUI's fatwa can be overcomed by determining their nasab relationship. Because the nasab relationship is one of the reasons for inheritance. So the authors conclude that the practice of IVF from husband and wife by another wife's womb is legally, and the children born through the process end up with surrogate mother who have conceived and given birth.
KH.HASYIM ASY’ARI’S QURANIC EXEGESIS ON MARIAGE
Authors: Al Amin Habibi
Published: March 2023

This Paper aims to describe living Qur’an of Tebuireng Santri Jombang, Jawa Timur Indonesia who have married.  This research confirms the presumption that the stronger santri identity, the more obvious the style of santri’s ideology. This research measures santri’s behavior by using KH. Hasyim Asy'ari's concept of marriage, Ḍaw' al-miṣbaḥ fῙ bayani aḥkam al-nikaḥ. The location is Pondok Pesantren Tebuireng, Jombang. Data were collected through interviews and observations.  This study concludes that santris Tebuireng, Jombang dominantly follow KH. Hasyim Asy’ari’ exegesis in Quran verses mariage, including marriage practices and household conflict handling.
Development of Abdullah Permata Jingga Mosque Website Interface with User Centered Design Method
Authors: Anugrah Nur Rahmanto  , Irsyad Arif Mashudi  , Salsabila Firdausy
Published: March 2023

Indonesia as a country with the largest Muslim population in the world, is inseparable from the existence of mosques. The mosque, as a place of worship for Muslims, should function properly, therefore the surrounding environment can benefit from it. Currently, mosques are starting to use website as a representation that describes the characteristics of mosques as well as a source of information for worshippers and the general public. One of the mosques initiated implementing the website is the Abdullah Permata Jingga Mosque. However, in the use of the Abdullah Permata Jingga Mosque website, it found a problem with the interface that had an impact in the form of information conveyed was very limited to be accessed by its users. Based on these problems, an analysis and development of the website interface was carried out with aims to design an interface that can meet user needs. The method used to process data is with a User Centered Design approach. In testing the usability of the frontend interface solution design of the Abdullah Permata Jingga Mosque website, it was carried out using the heuristic evaluation method. Heuristics are evaluate 10 aspects of the principle of usability in the user interface. The results of the evaluation obtained 8 aspects of the principle with the category of "Very High" usability results. These results show that the user interface design solution of the Abdullah Permata Jingga Mosque is in accordance with user needs.
Sistem Pakar Diagnosa Penyakit Paru-Paru Menggunakan Metode Case Based Reasoning
Authors: Septianda Reza Maulana  , Luqman Affandi  , Mamluatul Haniah
Published: March 2023

Kesehatan paru-paru sangatlah penting dalam keberlangsungan hidup kita, lingkungan yang kotor pun juga sangat berpengaruh dalam kesehatan hidup kita, banyak orang yang tidak peduli akan kesehatan paru-paru, sehingga banyak orang yang mengidap penyakit paru-paru. Saat ini dokter spesialis paru-paru tidak sebanding dengan penderita penyakit paru-paru. Tujuan dari penelitian ini membuat sistem pakar yang dapat menyelesaikan masalah penyakit paru-paru dan cara penanganannya dengan menerapkan metode Case Based Reasoning, serta mengetahui akurasi pada metode tersebut. Hasil pengujian tersebut menunjukkan bahwa sistem dapat memberikan kemudahan kepada pasien yang mana didapatkan dari hasil rata-rata kuesioner yang sudah diisi dengan rata-rata sebesar 86.8% dan metode Case Based Reasoning dapat digunakan dalam mendiagnosis penyakit paru-paru dengan nilai akurasi sebesar 90%.
DIGITALISASI SISTEM PERPUSTAKAAN MULTI LEVEL AKSES BERBASIS WEB (STUDI KASUS : SMA NEGERI 04 MAKASSAR)
Authors: Suryani  , Nur Madinah Yandriswan
Published: March 2023

Penggunaan teknologi komputer pada perpustakaan di Sma Negeri 4 Makassar saat ini masih sebatas pendataan anggota perpustakaan dan data buku saja. Banyaknya buku yang tersedia di perpustakaan, menjadi kendala bagi siswa dalam melakukan pencarian buku secara manual, selain itu belum ada sistem yang menyajikan informasi tentang koleksi buku, sehingga menyebabkan siswa masih terus melakukan pencarian buku, sekalipun buku tidak tersedia di perpustakaan. Peminjaman buku pun dicatat secara manual, sehingga managemen simpan pinjam buku tidak terorganisir dengan baik. Diperlukan suatu sistem yang dapat mengolah data koleksi buku , data anggota perpustakaan, data peminjaman sekaligus pengembalian buku yang bertujuan untuk meningkatkan kinerja pengelola perpustakaan agar lebih efektif. Digitalisasi sistem berbasis web tersebut dapat diakses oleh 2 user yaitu Admin dan Anggota. Observasi dilakukan untuk pengumpulan data kemudian melakukan wawancara untuk mengetahui kekurangan dari sistem perpustakaan. Sistem dibangun menggunakan metode waterfall mulai tahap analisis kebutuhan perangkat lunak hingga pemeliharaan. Pengujian sistem menggunakan black box untuk menguji fungsionalitas sistem, kemudian melakukan hosting dengan nama domain simpus.sman04mks.sch.id. Dengan adanya Digitalisasi sistem perpustakaan pada Sma Negeri 4 Makassar, dapat memudahkan manajemen perpustakaan mulai dari cetak kartu anggota otomatis, pendataan buku, peminjaman, pengembalian buku, pendataan anggota, serta memudahkan dalam report.
SISTEM INFORMASI PREDIKSI PERSEDIAAN OBAT DI APOTEK NAYLUN FARMA MENGGUNAKAN HOLT-WINTERS
Authors: Lestari Vivin Ayu , Ananta Ahmad Yuli , Basudewa Padang
Published: March 2023

Apotek merupakan fasilitas pelayanan kesehatan dalam menunjang terwujudnya kesehatan yang maksimal. Pada apotek dibutuhkan adanya pemanfaatan teknologi informasi dalam bidang sistem persediaan atau jual beli. Pada Apotek Naylun Farma terdapat bug pada sistem informasi sehingga ada beberapa fitur yang seharusnya menggunakan sistem diharuskan mencatat manual seperti fitur transaksi penjualan sehingga berdampak pada laporan penjualan. Oleh karena itu dibutuhkan pembuatan sistem informasi baru yang meliputi pembelian, penjualan, data obat dan prediksi. Prediksi adalah suatu usaha untuk memperkirakan kejadian di masa depan melalui kejadian di masa lalu. Dalam pengelolaan persediaan yang baik dan benar, jika terjadi kesalahan dalam perencanaan pengadaan obat hingga bisa menyebabkan terbentuknya kelebihan atau kekurangan persediaan obat. Kelebihan persediaan obat bisa merugikan, sebab menambahnya pengeluaran serta juga terbuangnya obat yang sudah kadaluarsa. Salah satu metode yang dapat digunakan dalam prediksi obat adalah metode Holt-Winters karena metode ini sangat baik dalam memprediksi pola data bersifat musiman dengan unsur trend yang timbul secara bersamaan dengan harapan untuk mempermudah dan membantu efisiensi waktu dalam kegiatan transaksi di Apotek Naylun Farma serta dapat membantu memprediksi persediaan obat. Hasil pengujian menunjukan bahwa nilai MAPE <10%, yang berarti nilai prediksi memiliki ketepatan tinggi, maka dapat disimpulkan bahwa metode Holt-Winters dapat di implementasi dengan baik untuk memprediksi persediaan obat di Apotek Naylun Farma. Selain itu pada penelitian ini juga dilakukan pengujian black box dan usability. Hasil pengujian black box menunjukan bahwa semua fitur yang dikembangakan dalam aplikasi ini dapat berjalan sesuai fungsinya, sedangkan hasil pengujian usability adalah 93,23% yang berarti sistem ini sangat layak untuk digunakan pengguna.
Analisis Performa Seleksi Atribut untuk Menentukan Potensi Mahasiswa Putus Studi
Authors: Wijayaningrum Vivi Nur , Putri Ika Kusumaning , Kirana Annisa Puspa , Mubarok Muhammad Rizki , Harahap Deatrisya Mirela , Hamesha Berryl Radian
Published: March 2023

Banyaknya kasus mahasiswa putus studi yang terjadi di sejumlah pendidikan tinggi menjadi perhatian khusus di berbagai negara. Efek yang ditimbulkan akibat masalah ini antara lain dapat menghambat perekonomian dan produktivitas di negara tersebut. Untuk mengatasi hal tersebut, beberapa algoritma telah digunakan untuk memprediksi potensi mahasiswa putus studi. Berbagai atribut data yang berkaitan dengan informasi mahasiswa, seperti data pribadi, riwayat akademik, dan latar belakang mahasiswa digunakan sebagai bahan pertimbangan mahasiswa tersebut berpotensi putus studi atau tidak. Namun, banyaknya atribut data yang digunakan pada proses prediksi memungkinkan terjadinya overfitting, menurunnya performa algoritma, dan menambah waktu komputasi. Pada penelitian ini, seleksi atribut data dilakukan dengan menggunakan Chi Square, Pearson Correlation Coefficient, dan Random Forest untuk selanjutnya dapat dilakukan prediksi menggunakan Multi-Layer Perceptron. Hasil dari skenario pengujian dengan menggunakan berbagai variasi banyaknya atribut data menunjukkan terjadinya peningkatan nilai akurasi dan F1-Score saat dilakukan seleksi atribut dengan nilai rata-rata di atas 0.8.
A Solidity implementation of TAVS
Authors: Larriba Antonio M. , López Damián
Published: March 2023

We present a Solidity smart contract implementation of the TAVS e-voting protocol. The Two Authorities Electronic Voting Scheme (TAVS) is a voting scheme that achieves universal verifiability with a reduced time-complexity both for the elector and the voting system. TAVS security derives from the RSA cryptosystem it employs, and the assumption of two entities that do not share information. We present a Solidity implementation which replaces one of these entities with an immutable smart contract in Ethereum based networks. By doing so, our implementation extends the security properties of TAVS and achieves a higher degree of resilience, verifiability, and availability. We open source the code of the implementation.
Computational comparative analysis identifies potential stemness-related markers for mesenchymal stromal/stem cells
Authors: Ghabriel Myret , El Hosseiny Ahmed , Moustafa Ahmed , Amleh Asma
Published: March 2023

Mesenchymal stromal/stem cells (MSCs) are multipotent cells that reside in multiple tissues are capable of self-renewal and differentiation into various cell types. These properties make them promising candidates for regenerative therapies. MSC identification is critical in yielding pure populations for successful therapeutic applications; however, the criteria for MSC identification proposed by the International Society for Cellular Therapy (ISCT) are inconsistent across different tissue sources. This study aimed to identify potential markers to be used together with the ISCT criteria to provide a more accurate means of MSC identification. Thus, we carried out a computational comparative analysis of the gene expression in human and mouse MSCs derived from multiple tissues to identify the differentially expressed genes that are shared between the two species. We show that six members of the proteasome degradation system are similarly expressed across MSCs derived from bone marrow, adipose tissue, amnion, and umbilical cord. Additionally, with the help of predictive models, we found that the expression profile of these genes correctly validated the identity of the MSCs across all the tissue sources tested. Moreover, using genetic interaction networks, we showed a possible link between these genes and antioxidant enzymes in the MSC antioxidant defense system, thereby pointing to their potential role in prolonging the life span of MSCs. According to our findings, members of the proteasome degradation system may serve as stemness-related markers.
Surgical resection of a giant cardiac angiosarcoma and reconstruction of involved right heart structures: A case report
Authors: Blindaru Andreea , Vasilescu Alexandru , Danet Andrei , Zimnicaru Oana , Cristu Maximilian , Tudorica Stefan , Borjog Tudor , Patrascu Oana , Badiu Catalin Constantin
Published: March 2023

We present the case of a young woman without a medical history who presented with a giant right atrial, transtricuspid, and right ventricular mass and in a severe clinical state. Multimodal imaging raised the suspicion of primary cardiac angiosarcoma. Due to rapid hemodynamic and respiratory deterioration, we were forced to perform surgical removal of the mass with a concomitant reconstruction of the involved right heart structures, only 48 h after presentation. The postoperative course was uneventful, and the patient was discharged from the intensive care unit 2 days later. Radical surgical resection with reconstruction of the resected heart structures was the only possible salvage option for giant angiosarcoma, which led to hemodynamic instability. Followed by chemotherapy, this radical approach may prolong survival.
Efficacy of traditional Chinese exercise for obesity: A systematic review and meta-analysis
Authors: Yang Ze , Huang Kai , Yang Yang , Xu Qike , Guo Qiaofeng , Wang Xiang
Published: March 2023

Background

Obesity is considered one of the biggest public health problems, especially in the background of the coronavirus disease 2019 (COVID-19) lockdown. It is urgent to find interventions to control and improve it. We performed this systematic review and meta-analysis to summarize the effect of traditional Chinese exercise on obesity.

Methods

We searched PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI), the Chinese Scientific Journal Database (VIP), the Chinese Biomedical Literature Database (CBM), and WanFang database for updated articles published from the inception of each database to June 2022. Randomized controlled trials (RCTs) on traditional Chinese exercise in weight reduction were included, and related data were extracted. The random-effects model was used to adjust for the heterogeneity of the included studies, and funnel plots were used to examine publication bias.

Results

A total of 701 participants were included in the 10 studies. Compared with the control group, the outcome of body weight [mean difference (MD) = −6.10; 95% CI = -8.79, -3.42], body mass index (MD = −2.03; 95% CI = -2.66, -1.41), body fat mass (MD = −3.12; 95% CI = -4.49, -1.75), waist circumference (MD = −3.46; 95% CI = -4.67, -2.24), hip circumference (MD = −2.94; 95% CI = -4.75, -1.30), and waist-to-hip ratio (MD = −0.04; 95% CI = -0.06, -0.03) in the intervention group had significant differences. Egger’s test and funnel plots showed that the potential publication bias of the included studies was slight (p = 0.249).

Conclusion

Traditional Chinese exercise is an effective treatment for obesity; people under the COVID-19 lockdown could do these exercises to control weight. However, a precise and comprehensive conclusion calls for RCTs on a larger scale with more rigorous designs considering the inferior methodological quality and limited retrieved articles.

Systematic review registration

www.crd.york.ac.uk/PROSPERO/, identifier CRD42021270015.
Changes in spatial patterns of biomass energy potential from biowaste in China from 2000 to 2020
Authors: Lang Lixia , Chen Yanbi , Liu Yan , Wu Jianxi , Yu Yongkun , Wang Yan , Chen Xingpeng , Zhang Zilong
Published: March 2023

Introduction: Developing biomass energy to alleviate the worldwide energy crisis has become a global priority. In order to ensure the optimal utilization of biomass energy, it is necessary to calculate a country’s biomass energy potential, so as to provide support for the formulation of biomass energy macro policies, especially for the sustainable supply of raw materials.

Methods: This study constructs the biomass inventory, including crop straw, livestock manure, forest residues and municipal solid waste, and estimates the potential of the biomass energy supply of 31 provinces (autonomous regions and municipalities) in China from 2000 to 2020. The changes in the spatial pattern of the biomass energy supply are explored. Taking 2020 as a targeted year, the spatial patterns of biomass energy density defined as the biomass energy per land area and per rural person is then analyzed.

Results: The results show that from 2000 to 2020, China’s biomass energy converted into coal equivalent generally showed a fluctuating upward trend from 139,141.73 × 104 tce in 2000–146,133.20 × 104 tce in 2020, with an average annual growth rate of 0.24%. The biomass energy is dominated by livestock manure and crop straw and the four types of biomass energy show different changes but with an overall upward trend. The spatial patterns of the biomass energy potential are generally uneven, with significant inter-provincial differences and obvious regional differences in cold and hot spots. In 2020, the energy density of the biomass energy potential is characterized by “two highs and two lows,” i.e., the biomass energy density per unit land area is “high in the east and low in the west” and the per capita biomass energy density in rural areas is “high in the north and low in the south”.

Discussion: The aims of this study are to assess the capacity of biomass resources in China to support a bio-based economy and provide a reference for China’s biomass energy policy formulation and strategic layout. Research shows that in order to further develop biomass energy, the development and utilization of biomass energy should be promoted in combination with China’s regional characteristics, rational planning and local conditions.
How can management ability promote green technology innovation of manufacturing enterprises? Evidence from China
Authors: Guang-lin Xu , Tao Meng
Published: March 2023

Management ability improves organizational learning and innovation ability, thereby improving enterprise performance. Higher-ability management has more flexible and adaptive strategic thinking and ability, allowing it to quickly capture market opportunities, formulate long-term digital transformation strategies, gain competitive advantage through product and service innovation, and thus promote enterprise innovation performance. The research sample for this paper is A-share listed companies in the manufacturing industry from 2008 to 2019, and it integrates management capabilities with digital economy and green technology innovation. Our research shows that management ability can significantly boost manufacturing enterprises’ green technology innovation. Furthermore, regardless of whether the enterprise is state-owned or non-state-owned, management ability is positively related to green technology innovation performance, and internal control has a significant positive regulating effect on the relationship between them. Given these findings, this study offers important insights for strengthening the integration of the digital economy and green transformation, emphasizing the rationality of management capabilities, and developing policies for various enterprises.
Willingness of Chinese households to pay extra for hydrogen-fuelled buses: A survey based on willingness to pay
Authors: Wang Shuai , Tan Yang , Fukuda Hiroatsu , Gao Weijun
Published: March 2023

Hydrogen-fuelled buses play an important role in the construction of low-carbon cities as a means of green travel. Beijing, as a pilot city of hydrogen-fuelled buses in China, is very important in the promotion of hydrogen-fuelled buses in China. Unfortunately, the public acceptance of hydrogen-fuelledfuelled buses and their environmental positive externality value have not been studied. In this paper, we investigated the willingness of Beijing households to pay for the promotion of hydrogen-fuelled buses and its influencing factors by means of a web-based questionnaire. The spike model was also used to estimate the willingness to pay (WTP) for hydrogen buses. The results show that the WTP of Beijing households is CNY 3.19 per trip. The value of a positive environmental externality is approximately CNY 29.15 million per trip. Household income level, environmental knowledge, individual environmental ethics, and perceived behavioural control are the main influencing factors of WTP. Therefore, policymakers should strengthen publicity efforts to increase individuals’ environmental awareness and environmental ethics and optimize the layout of hydrogen-fuelled bus schedules and riding experiences to improve individuals’ perceptual and behaviour control. Finally, the positive environmental externality value of hydrogen buses should be valued, which will help increase investor interest.
The impact of listed companies’ participation in targeted poverty alleviation on financing constraints: Mediating effect based on policy resources
Authors: Huo Zenghui , Xia Yufei , Liu Ding , Zhang Mei
Published: March 2023

This article aims to explore the inner relationship between targeted poverty alleviation and financing constraints of listed companies, and further reveal the underlying impact mechanism. Based on the data of listed companies in Shanghai and Shenzhen A-share main board participating in targeted poverty alleviation from 2017 to 2020, graded response models and mediation models are conducted. From the perspective of resource motivation, the study examined the relationship between the investment in targeted poverty alleviation and financing constraints of listed companies and introduces policy resources as mediator variable to reveal the underlying mechanism. The study found that the participation of listed companies in targeted poverty alleviation can significantly ease financing constraints, and policy resources can play an intermediary effect in the process. For enterprises with different equity nature, in state-owned enterprises, policy resources play a small intermediary role between poverty alleviation inputs and financing constraints. Meanwhile, in non-state-owned enterprises, government subsidies play a significant intermediary role, and tax incentives play a small intermediary role. In response to this, policy suggestions such as improving the disclosure of poverty alleviation information, expanding policy preferences, and increasing poverty alleviation subsidies have been suggested.
Seasonality of phytoplankton biomass and composition on the Cape Canaveral shelf of Florida: Role of shifts in climate and coastal watershed influences
Authors: Stelling Ben , Phlips Edward , Badylak Susan , Landauer Leslie , Tate Mary , West-Valle Anne
Published: March 2023

Seasonal patterns of phytoplankton biomass and composition in the inner continental shelf off Cape Canaveral on the east coast of Florida were examined for a 6-year period (2013–2019). In situ water samples were collected and analyzed for chlorophyll a, phytoplankton biomass and composition, along with water quality parameters. Regional satellite data on chlorophyll a, and temperature was also obtained from NASA. Average chlorophyll a values over the study period ranged from 0.63 ± 0.03 μg L−1 in the summer to 2.55 ± 0.10 μg L−1 in the fall. Phytoplankton community composition also showed seasonal differences, with persistent dominance by picoplanktonic cyanobacteria in the summer, but mixed dominance by picocyanobacteria and dinoflagellates in the fall. Seasonal differences were attributed to a shift in predominant seasonal wind directions, which drive water along the coast from the north in the fall and winter, but from the south in the spring and summer, including eddies and upwelling from the Gulf Stream. Water masses moving along the Florida coast from the north are influenced by nutrient and phytoplankton-enriched inputs from estuaries along the north coast of Florida, explaining the higher phytoplankton biomass levels on the Cape Canaveral shelf in the fall and winter. Seasonal patterns observed in this study demonstrate the importance of allochthonous influences on phytoplankton biomass and composition, and highlight the potential sensitivity of phytoplankton communities to continuing cultural eutrophication and future climate changes, including the frequency and intensity of tropical storms, and alterations in discharges from land.
Developing a non-invasive diagnostic model for pediatric Crohn’s disease using RNA-seq analysis
Authors: He Bin , Wang Fang , Shu Junhua , Cheng Ying , Zhou Xiaoqing , Huang Tao
Published: March 2023

Introduction: Pediatric Crohn’s disease is a chronic inflammatory condition that affects the digestive system in children and adolescents. It is characterized by symptoms such as abdominal pain, diarrhea, weight loss, and malnutrition, and can also cause complications like growth delays and delayed puberty. However, diagnosing pediatric Crohn’s disease can be difficult, especially when it comes to non-invasive methods.

Methods: In this study, we developed a diagnostic model using RNA-seq to analyze gene expression in ileal biopsy samples from children with Crohn’s disease and non-pediatric Crohn’s controls.

Results: Our results showed that pediatric Crohn’s disease is associated with altered expression of genes involved in immune response, inflammation, and tissue repair. We validated our findings using two independent datasets from the Gene Expression Omnibus (GEO) database, as well as through one prospective independent dataset, and found that our model had a high accuracy rate.

Discussion: These findings suggest the possibility of non-invasive diagnosis for pediatric Crohn’s disease and may inform the development of targeted therapies for this condition.
Are respectful maternity care (RMC) interventions effective in reducing intrapartum mistreatment against adolescents? A systematic review
Authors: Habib Helen H. , Mwaisaka Jefferson , Torpey Kwasi , Maya Ernest Tei , Ankomah Augustine
Published: March 2023

Intrapartum mistreatment of women by health professionals is a widespread global public health challenge. It leads to a decreased quality of maternity care and is evinced to precipitate detrimental maternal and neonatal outcomes, especially among adolescents. Relatedly, research indicates that Respectful Maternity Care (RMC) interventions are especially effective in mitigating intrapartum mistreatment and improving birth outcomes. However, evidence on the success of RMC, specifically for adolescents, is insufficient and unaggregated. Accordingly, this review specifically aims to synthesize existing evidence on RMC care provision to adolescent parturients. This review searched for relevant literature from published and gray sources including PubMed, ScienceDirect, Cochrane, CINAHL, PsycINFO, Scopus, as well as Population Council, WHO and White Ribbon Alliance data sources published between January 1990 and December 2021. Based on eligibility, studies were selected and quality appraised after which thematic analysis and narrative synthesis was conducted. Twenty-nine studies were included in the systematic review. Due to paucity and heterogeneity of quantitative studies, the review was limited to a thematic analysis. Adolescent and health provider perspectives alike underscored the burden and outcomes of mistreatment. Need for RMC interventions to improve quality of maternity care was recommended by majority of studies.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier: CRD42020183440.
The transient receptor potential channels in rheumatoid arthritis: Need to pay more attention
Authors: Niu Mengwen , Zhao Feng , Chen Rui , Li Ping , Bi Liqi
Published: March 2023

Rheumatoid arthritis (RA) is characterized by the augment of vascular permeability, increased inflammatory cells infiltration, dysregulated immune cells activation, pannus formation and unbearable pain hyperalgesia. Ca2+ affect almost every aspect of cellular functions, involving cell migration, signal transduction, proliferation, and apoptosis. Transient receptor potential channels (TRPs) as a type of non-selective permeable cation channels, can regulate Ca2+ entry and intracellular Ca2+ signal in cells including immune cells and neurons. Researches have demonstrated that TRPs in the mechanisms of inflammatory diseases have achieved rapid progress, while the roles of TRPs in RA pathogenesis and pain hyperalgesia are still not well understood. To solve this problem, this review presents the evidence of TRPs on vascular endothelial cells in joint swelling, neutrophils activation and their trans-endothelial migration, as well as their bridging role in the reactive oxygen species/TRPs/Ca2+/peptidyl arginine deiminases networks in accelerating citrullinated proteins formation. It also points out the distinct functions of TRPs subfamilies expressed in the nervous systems of joints in cold hyperalgesia and neuro-inflammation mutually influenced inflammatory pain in RA. Thus, more attention could be paid on the impact of TRPs in RA and TRPs are useful in researches on the molecular mechanisms of anti-inflammation and analgesic therapeutic strategies.
Post-translational modifications confer amphotericin B resistance in Candida krusei isolated from a neutropenic patient
Authors: Zhang Li , Xiao Jinzhou , Du Mingwei , Lei Wenzhi , Yang Weiwei , Xue Xiaochun
Published: March 2023

Neutropenia is a common complication in the treatment of hematological diseases and the most common predisposing factor for invasion by fungi, such as Candida krusei. Recent studies have shown that C. krusei, a life-threatening pathogen, has developed resistance to amphotericin B (AMB). However, the mechanisms that led to the rapid emergence of this AMB-resistant phenotype are unclear. In this study, we found the sensitivity for AMB could be promoted by inhibiting histone acyltransferase activity and western blot analysis revealed differences in the succinylation levels of C. krusei isolated from immunocompromised patients and of the corresponding AMB-resistant mutant. By comparative succinyl-proteome analysis, we identified a total of 383 differentially expressed succinylated sites in with 344 sites in 134 proteins being upregulated in the AMB-resistant mutant, compared to 39 sites in 23 proteins in the wild-type strain. These differentially succinylated proteins were concentrated in the ribosome and cell wall. The critical pathways associated with these proteins included those involved in glycolysis, gluconeogenesis, the ribosome, and fructose and mannose metabolism. In particular, AMB resistance was found to be associated with enhanced ergosterol synthesis and aberrant amino acid and glucose metabolism. Analysis of whole-cell proteomes, confirmed by parallel reaction monitoring, showed that the key enzyme facilitating lysine acylation was significantly upregulated in the AMB-resistant strain. Our results suggest that lysine succinylation may play an indispensable role in the development of AMB resistance in C. krusei. Our study provides mechanistic insights into the development of drug resistance in fungi and can aid in efforts to stifle the emergence of AMB-resistant pathogenic fungi.
Valorisation of crustacean and bivalve processing side streams for industrial fast time-to-market products: A review from the European Union regulation perspective
Authors: Zou Yang , Heyndrickx Marc , Debode Jane , Raes Katleen , de Pascale Donatella , Behan Patrice , Giltrap Michelle , O’Connor Christine , Solstad Runar Gjerp , Lian Kjersti , Altintzoglou Themistoklis , Dragøy Ragnhild , Scheers Nathalie , Undeland Ingrid , Robbens Johan
Published: March 2023

A massive amount of crustaceans and bivalves are consumed each year, leading to millions of tons of processing side streams from the seafood industry. Considering the current trend of (bio)circular and zero-waste food production, crustacean and bivalve processing side streams (CBPS) seem a promising and emerging resource for producing high-value-added products. This paper highlights the general composition of CBPS with high commercial values, namely, protein, lipids, carotenoids, minerals and chitins. The extraction strategies of these fractions, including conventional chemical and environmentally friendly methods, are also discussed. This review presents and summarises CBPS as raw materials for developing fast time-to-market products complying with specific EU regulations, including animal feeds, bio-pesticide/stimulants, and cosmetic ingredients. This paper also provides insights into challenges of applying CBPS as raw materials to generate products for human consumption.
Indirect photodegradation of ofloxacin in simulated seawater: Important roles of DOM and environmental factors
Authors: Liu Shukai , Cui Zhengguo , Bai Ying , Ding Dongsheng , Yin Junshuang , Su Rongguo , Qu Keming
Published: March 2023

Dissolved organic matter (DOM) plays a non-negligible role in the indirect photodegradation of organic contaminants. This research investigated the roles of DOM and the environmental factors (salinity, pH, NO3−, and HCO3−) in the indirect photodegradation of ofloxacin (OFX) in simulated seawater. Results showed that DOM can significantly accelerate the indirect photodegradation of OFX, and 1O2 and 3DOM* were the main reactive intermediates (RIs) that could promote the indirect photodegradation of OFX. Fluorescence excitation–emission matrix spectroscopy–parallel factor analysis (EEMs-PARAFAC) was used to divide DOM into four fluorescence components. The indirect photodegradation rate of OFX was affected by DOM structure, and terrigenous DOM usually produced more RIs to promote the indirect photodegradation of OFX. Increased salinity significantly promotes the indirect photodegradation of OFX, while increased NO3− concentration had no effect on the OFX indirect photodegradation. pH affected the formation of RIs and the structure of OFX, thereby affecting the indirect photodegradation of OFX. The indirect photodegradation rate of OFX increased in the HCO3− solution, which is due to the formation of carbonate radical (CO3−). This study is essential in understanding the role of DOM in OFX indirect photodegradation and providing a novel insight into the fate, removal, and transformation of OFX.
Preparation of SiO2 coated carbon fibers and its interfacial properties with cement paste matrix
Authors: Geng Yanan , Ren Qiang , Yang Zengmin , He Dan , Wu Zhiqiang , Cai Jingxuan , Zhang Chunmei , Cheng Xiaowei
Published: March 2023

As a porous brittle material, oil well cement in oil and gas well cementing is difficult to bear complex loads, which can easily lead to the failure of the mechanical integrity of cement sheath. In this paper, SiO2 coating-CF toughening material was obtained by SiO2 modified carbon fibers (CFs) surface. In addition, the mechanical properties and mechanism of SiO2 coated-CF cement stone were discussed. The obtained results showed that the mechanical properties of SiO2 coated-CF cement paste are significantly improved. After 14 days of curing, the compressive strength can reach 32.98 MPa and the tensile strength is increased by 162%. The CF after adding SiO2 surface film improves the adhesion between the interface and the fiber by forming chemical bonds at the bonding surface with the cement paste, so as to improve the CF reinforced cement paste.
Barriers and facilitators to interhospital transfer of acute pulmonary embolism: An inductive qualitative analysis
Authors: DeBerry Jacob , Rali Parth , McDaniel Michael , Kabrhel Christopher , Rosovsky Rachel , Melamed Roman , Friedman Oren , Elwing Jean M. , Balasubramanian Vijay , Sahay Sandeep , Bossone Eduardo , Farmer Mary Jo S. , Klein Andrew J. P. , Hamm Megan E. , Ross Charles B. , Rivera-Lebron Belinda N.
Published: March 2023

Background

Interhospital transfer (IHT) of patients with acute life-threatening pulmonary embolism (PE) is necessary to facilitate specialized care and access to advanced therapies. Our goal was to understand what barriers and facilitators may exist during this transfer process from the perspective of both receiving and referring physicians.

Methods

This qualitative descriptive study explored physician experience taking care of patients with life threatening PE. Subject matter expert physicians across several different specialties from academic and community United States hospitals participated in qualitative semi-structured interviews. Interview transcripts were subsequently analyzed using inductive qualitative description approach.

Results

Four major themes were identified as barriers that impede IHT among patients with life threatening PE. Inefficient communication which mainly pertained to difficulty when multiple points of contact were required to complete a transfer. Subjectivity in the indication for transfer which highlighted the importance of physicians understanding how to use standardized risk stratification tools and to properly triage these patients. Delays in data acquisition were identified in regards to both obtaining clinical information and imaging in a timely fashion. Operation barriers which included difficulty finding available beds for transfer and poor weather conditions inhibiting transportation. In contrast, two main facilitators to transfer were identified: good communication and reliance on colleagues and dedicated team for transferring and treating PE patients.

Conclusion

The most prominent themes identified as barriers to IHT for patients with acute life-threatening PE were: (1) inefficient communication, (2) subjectivity in the indication for transfer, (3) delays in data acquisition (imaging or clinical), and (4) operational barriers. Themes identified as facilitators that enable the transfer of patients were: (1) good communication and (2) a dedicated transfer team. The themes presented in our study are useful in identifying opportunities to optimize the IHT of patients with acute PE and improve patient care. These opportunities include instituting educational programs, streamlining the transfer process, and formulating a consensus statement to serve as a guideline regarding IHT of patients with acute PE.
Related donor platelet transfusion improves platelet transfusion refractoriness in hematological patients
Authors: Zhang Jing-Cheng , Ni Li-Hong , Tu Yan , Hu Hui-Xian
Published: March 2023

Objective

Transfusion of HLA-matched platelets can reduce the effect of alloimmune responses on platelet transfusion efficacy; however, finding HLA-matched platelets in the population is nearly impossible. Almost all HLA-matched platelets from related are half-matched, but the hemostatic efficacy of related donor platelets is unclear. Our goal was to compare the hemostatic effect of related donated platelets and unrelated donors platelets.

Methods

In this retrospective cohort study, we included acute leukemia and myelodysplastic syndrome patients with thrombocytopenia after chemotherapy. These patients were all transfused with platelets. This study excluded patients younger than 16 years and older than 65 years, or patients with abnormal coagulation parameters during platelet transfusion. We compared the hemostatic effect of related donated platelets and unrelated donors platelet. The primary outcome was transfusion efficacy after platelet transfusion, and the number of platelet counts and corrected count increments at 24 h after platelet transfusion.

Result

We analyzed 31 patients who received platelet transfusions from related donors (Treatment group) and 35 patients who received platelet transfusions from unrelated donors (Comparator group). Except for the relatively small proportion of patients with myelodysplastic syndrome in the treatment group, baseline clinical and laboratory characteristics were similar between the two groups. Hemostasis and prevention of bleeding in the treatment group showed significant superiority; the number of platelets increased 24 h after platelet transfusion in the treatment group was significantly higher than that in the comparator group. After 24 h, the corrected count increments treatment group was also higher than the comparator group; in the treatment group, the transfusion effect was better when the three sites of HLA-A, B, and C were identical, and the different blood types of platelet donors and recipients did not affect the transfusion effect.

Conclusion

Related donated platelets have better hemostasis and prevention effects, and no increase in adverse blood transfusion reactions. It may be a better transfusion strategy for platelet refractoriness patients in emergency situations.
Electron shuttle-dependent biofilm formation and biocurrent generation: Concentration effects and mechanistic insights
Authors: Zhu Xiao , Dou Fei , Long Mingliang , Wang Xinxin , Liu Wei , Li Fangbai , Liu Tongxu , Wu Yundang
Published: March 2023

Introduction

Electron shuttles (ESs) play a key role in extracellular electron transfer (EET) in Shewanella oneidensis MR-1. However, the quantification relationship between ES concentration, biofilm formation, and biocurrent generation has not been clarified.

Methods

In this study, 9,10-anthraquinone-2-sulfonic acid (AQS)-mediated EET and biofilm formation were evaluated at different AQS concentrations in bioelectrochemical systems (BESs) with S. oneidensis MR-1.

Results and discussion

Both the biofilm biomass (9- to 17-fold) and biocurrent (21- to 80-fold) were substantially enhanced by exogenous AQS, suggesting the dual ability of AQS to promote both biofilm formation and electron shuttling. Nevertheless, biofilms barely grew without the addition of exogenous AQS, revealing that biofilm formation by S. oneidensis MR-1 is highly dependent on electron shuttling. The biofilm growth was delayed in a BES of 2,000 μM AQS, which is probably because the redundant AQS in the bulk solution acted as a soluble electron acceptor and delayed biofilm formation. In addition, the maximum biocurrent density in BESs with different concentrations of AQS was fitted to the Michaelis–Menten equation (R2 = 0.97), demonstrating that microbial-catalyzed ES bio-reduction is the key limiting factor of the maximum biocurrent density in BESs. This study provided a fundamental understanding of ES-mediated EET, which could be beneficial for the enrichment of electroactive biofilms, the rapid start-up of microbial fuel cells (MFCs), and the design of BESs for wastewater treatment.
Gait and turning characteristics from daily life increase ability to predict future falls in people with Parkinson's disease
Authors: Shah Vrutangkumar V. , Jagodinsky Adam , McNames James , Carlson-Kuhta Patricia , Nutt John G. , El-Gohary Mahmoud , Sowalsky Kristen , Harker Graham , Mancini Martina , Horak Fay B.
Published: March 2023

Objectives

To investigate if digital measures of gait (walking and turning) collected passively over a week of daily activities in people with Parkinson's disease (PD) increases the discriminative ability to predict future falls compared to fall history alone.

Methods

We recruited 34 individuals with PD (17 with history of falls and 17 non-fallers), age: 68 ± 6 years, MDS-UPDRS III ON: 31 ± 9. Participants were classified as fallers (at least one fall) or non-fallers based on self-reported falls in past 6 months. Eighty digital measures of gait were derived from 3 inertial sensors (Opal® V2 System) placed on the feet and lower back for a week of passive gait monitoring. Logistic regression employing a “best subsets selection strategy” was used to find combinations of measures that discriminated future fallers from non-fallers, and the Area Under Curve (AUC). Participants were followed via email every 2 weeks over the year after the study for self-reported falls.

Results

Twenty-five subjects reported falls in the follow-up year. Quantity of gait and turning measures (e.g., number of gait bouts and turns per hour) were similar in future fallers and non-fallers. The AUC to discriminate future fallers from non-fallers using fall history alone was 0.77 (95% CI: [0.50–1.00]). In contrast, the highest AUC for gait and turning digital measures with 4 combinations was 0.94 [0.84–1.00]. From the top 10 models (all AUCs>0.90) via the best subsets strategy, the most consistently selected measures were variability of toe-out angle of the foot (9 out of 10), pitch angle of the foot during mid-swing (8 out of 10), and peak turn velocity (7 out of 10).

Conclusions

These findings highlight the importance of considering precise digital measures, captured via sensors strategically placed on the feet and low back, to quantify several different aspects of gait (walking and turning) during daily life to improve the classification of future fallers in PD.
Concussions in young adult athletes: No effect on cerebral white matter
Authors: Hoffman Linda J. , Mis Rachel E. , Brough Caroline , Ramirez Servio , Langford Dianne , Giovannetti Tania , Olson Ingrid R.
Published: March 2023

Introduction

The media’s recent focus on possible negative health outcomes following sports- related concussion has increased awareness as well as anxiety among parents and athletes. However, the literature on concussion outcomes is equivocal and limited by a variety of diagnostic approaches.

Methods

The current study used a rigorous, open- access concussion identification method—the Ohio State University Traumatic Brain Injury Identification method (OSU TBI-ID) to identify concussion and periods of repeated, subclinical head trauma in 108 young adult athletes who also underwent a comprehensive protocol of cognitive tests, mood/anxiety questionnaires, and high-angular-resolution diffusion-weighted brain imaging to evaluate potential changes in white matter microstructure.

Results

Analyses showed that athletes with a history of repetitive, subclinical impacts to the head performed slightly worse on a measure of inhibitory impulse control and had more anxiety symptoms compared to those who never sustained any type of head injury but were otherwise the same as athletes with no history of concussion. Importantly, there were no group differences in cerebral white matter as measured by tract- based spatial statistics (TBSS), nor were there any associations between OSU TBI-ID measures and whole-brain principal scalars and free-water corrected scalars.

Discussion

Our results provide support for the hypothesis that it is not concussion per se, but repetitive head impacts that beget worse outcomes.