bluuebunny/crossref_metadata_2025 huggingface dataset:
The Correlation of E-cadherin Expression with Tumor Gradeand Tumor Budding in Endometrioid Endometrial Carcinoma
Authors: Pemuda Haris , Asri Aswiyanti , Zuryati Nizar Rachmadijah , Yetti Husna
Published: October 2022

BackgroundEndometrial carcinoma is the fourth most common malignancy among women worldwide with increasing incidence and death rate every year. One of the types of endometrial carcinoma is endometrioid carcinoma, originated from atypical hyperplasia and develop into carcinoma. Lack of intercellular cohesiveness in the epithelial tumors such as endometrioid carcinoma occur due to lack of expression of E-cadherin. It can also causetumor invasion and metastatic through the epithelial-mesenchymal transition (EMT) process. Tumor differentiation and tumor budding are presumed to be histopathologic representations due to lack of cohesiveness and the occurrence of the EMT process so that these two things need to be related with the expression of E-cadherin on tumor cells.MethodsAn observational study was conducted using a cross-sectional approach with 46 cases of endometrioid endometrial carcinoma.Samples were obtained from 4 Anatomical Pathology Laboratories in West Sumatra during 2016-2019 in the form of paraffin blocks and HE slides that obtained from hysterectomy surgery. Reevaluation of tumor grade and tumor budding in HE slides was performed. E-cadherin expression in tumor cells was seen by immunohistochemical staining. Bivariate statistical analysis was performed using Fisher's Exact test and the results were considered significant if the p value was <0.05.ResultsSpecimens with negative E-cadherin expression were more common in grade 2 tumors (41.7%) and grade 3 tumors (50.0%) and in specimes with positive tumor budding (91.7%). Statistical analysis revealed a significant correlation between E-cadherin expression with tumor grade (p=0.000) and tumor budding (p=0.000).ConclusionExpression of E-cadherin has a significant correlation with the tumor grade and tumor budding in endometrioid endometrial carcinoma.
Relationship between Age and Gender with Histopathological Type of Nasopharyngeal Carcinoma
Authors: Melvern Bryan , Karlowee Vega , Dewi Kusuma Astuti Meira
Published: October 2022

BackgroundNasopharyngeal carcinoma (NPC) is a malignancy with a high incidence in Indonesia. Recent studies had found several factors that influence the incidence and prognosis of NPC including age, sex, and histopathological type. This study aimed to determine the relationship between age and sex with the histopathological type of NPC.MethodsSubjects were NPC patients diagnosed by the Anatomical Pathology Department of Dr. Kariadi General Hospital Medical Center (RSUP Dr. Kariadi) from 1st January 2017-31st December 2019. Data were collected from the medical record. The relationship between age and sex with the histopathological type of NPC was examined. ResultsThere were 201 NPC patients during 2017-2019 in RSUP Dr. Kariadi. The highest number of NPC incidence was in the range of 54-59 years old. There were more males than females at the ratio of 2.24:1. Undifferentiated non-keratinizing cell carcinoma type NPC was the most common type (90.5% of NPC patients), followed by differentiated non-keratinizing cell carcinoma and squamous cell carcinoma consecutively. Both age and sex had no significant relationship with the histopathological type of NPC (p>0.05).ConclusionThere was no relationship between age and sex with the histopathological type of NPC.
Clinicopathological Features of Neoadjuvant Chemotherapy Response to Triple Negative Breast Cancer in Dr. Hasan Sadikin General Hospital
Authors: Savitri Widya , Surjawathy Hernowo Bethy , Suryanti Sri
Published: October 2022

BackgroundTriple Negative Breast Cancer (TNBC) accounts for 9-17% of all breast cancer diagnoses. TNBC has a high proliferation index and a poor prognosis with a higher response rate to neoadjuvant chemotherapy, but does not correlate with Overall Survival (OS) due to chemoresistence in more than 50% of TNBC. Neoadjuvant chemotherapy with anthracycline (doxorubicin) based regimens in combination with fluorouracil and cyclophosphamide (FAC) is still an option for TNBC. The aim of this study was to determine association between clinicopathological profile and response to neoajuvan chemotherapy in TNBC at Dr. Hasan Sadikin Bandung which is a referral hospital in West Java.MethodsThis study used an analytic observational method with a cross-sectional design. The research sample consisted of 40 TNBC cases from January 2017 to December 2019 at Dr. Hasan Sadikin hospital. Data obtained from medical records and archives of the Anatomical Pathology Laboratory consist of clinical response to neoadjuvant chemotherapy, age, tumor size, lymph node metastases and distant metastases, clinical stage, type of histopathology and lymphovascular vessel invasion.ResultsIn 40 cases of TNBC, 20 cases responded and 20 cases did not respond to neoadjuvant chemotherapy. In the non-response group, there were 90% of cases with histopathologic type invasive carcinoma of no special type and 75% showed invasion of lymphovascular vessels. There were no significant differences in age, tumor size, lymphovascular vessel invasion, stage, or histopathological type in the response and non-response groups.ConclusionThere is no correlation between clinicopathological features and neoadjuvant chemotherapy response in the case of Triple Negative Breast Cancer (TNBC). This can be caused by other factors including high heterogeneous tumor microenvironment (TME).
The Role of Vascular Endothelial Growth Factor (VEGF) in the Pathogenesis of the Placenta Accreta Spectrum
Authors: Linggodigdo Michelle , Hellyanti Tantri , Kusmardi
Published: October 2022

Placenta accreta spectrum (PAS) is a cause of serious maternal morbidity and mortality. FIGO 2020 designated PAS into grade 1 (non-invasive), grade 2 (superficial invasion), grade 3A (deep invasion), grade 3D (deep invasion with disruption of the serosa), and grade 3E (deep invasion with adherence to extrauterine structures). Currently, the trophoblast cell in accreta spectrum is associated with similar characteristics to cancer. Both conditions can induce angiogenesis, marked by upregulation of vascular endothelial growth factor (VEGF). This resulted in the formation of extensive neovascularization. The secretion of VEGF is induced by hypoxia, which was related to risk factor of PAS occurrence; defect of the decidua due to endometrial tissue damage.
Histomorphological and Demographic Profile of Breast Carcinoma in Anatomical Pathology Department FKUI/RSCM 2016-2019
Authors: Juwitasari Wongkar Fresia , Hellyanti Tantri , Hayati Amal
Published: October 2022

BackgroundInvasive breast carcinoma (IBC) is the most commonly diagnosed cancer in woman in the world and Indonesia. IBC is classified into two main categories: IBC of no special type (NST) and special types. This retrospective study aims to provide histomorphological profile of mastectomy cases of IBC in Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital (PA FKUI/RSCM) 2016-2019.MethodsThis is a descriptive research with cross-sectional design of mastectomy cases, using secondary data from the archives of PA FKUI/RSCM, starting from 2016- 2019. Collecting clinical data as well as observing several histopathologic parameters including histological type, grade, atypical mitotic features, lymphovascular invasion, and lymph node metastases. Tumour classification was made based on the WHO breast criteria in 2019.ResultsDuring the 2016-2019 period there were 144 cases of IBC. 99.3% of cases occurred in female patients, mostly in the age group from 40 to 59 years and unilateral. The majority had tumour sizes ranging >2-5 cm and were stage II. About a third of cases had received neoadjuvant chemotherapy, most commonly in advanced local stage tumors. Most histologic type (65.3%) were IBC of NST and 52.8% of cases were grade 2. There were 92 (63.4%) cases with atypical mitotic features, most commonly found in stage III. Lymphovascular invasion was found in 38.9% of cases and lymph node metastasis was found in 63.2% of cases.ConclusionIBC is the most common cancer in woman, with the most common histologic type were IBC, grade 2, stage II or more. Most of the cases show atypical mitosis, which is most commonly found in stage III. The findings of lymphovascular invasion did not always coincide with the findings of lymph node metastases.
Asymptomatic Bacterial Infection in Pregnancy: A new update
Authors: Awad Manal M. , Elsahar Maher I.
Published: October 2022

Urinary tract infection is more common in women than in men and is usually associated with a bacterial infection which causes bacteriuria as one of the symptoms/diagnoses of bacterial in-fection; however, asymptomatic bacterial infections sometimes do not need argent treatment, but in specific causes such as pregnancy may require medical intervention. This study analyzes 210 articles and relevant guidelines for Asymptomatic bacterial infection (bacteriuria) in pregnant women in the U.S., U.K., and Canada. Material and Methods: The pro-cedures are compared to the literature, including various studies on rates and cost-benefit analy-sis. In conclusion, several articles and guides prefer routinely testing pregnant in the first tri-mester.
Pharmaceutical and pharmacokinetic evaluation of a newly formulated multiparticulate matrix of levodopa and carbidopa
Authors: Imbeah Emelia Priscilla , Adi-Dako Ofosua , N’guessan Benoit , Kukuia Kennedy Kwami Edem , Dankyi Benedicta Obenewaa , Adams Ismaila , Ofori-Attah Ebenezer , Appiah-Opong Regina , Amponsah Seth Kwabena
Published: October 2022

Levodopa is routinely co-administered with carbidopa in the management of Parkinson’s disease. Although the aforementioned combination therapy is effective, there may be fluctuating plasma levels of levodopa after oral administration. We formulated and evaluated the kinetic characteristics of the chitosan-pectin-based multiparticulate matrix of levodopa and carbidopa. Pectin was extracted from the cocoa husk, and the chitosan-pectin-based matrix was prepared by wet granulation. Formulations were evaluated for drug-excipient compatibility, drug content, precompression properties and in vitro release. For pharmacokinetic evaluation, rats were put into groups and administered either chitosan-pectin based matrix of levodopa/carbidopa, Sinemet® CR or levodopa/carbidopa immediate release powder. Rats were administered the different formulations of levodopa/carbidopa (20/5 mg/kg) per os every 12 hours. The pharmacokinetic parameters of levodopa were estimated for the various treatment groups. The percentage content of levodopa and carbidopa in the various formulations was within the acceptance criteria. The AUC0-24 for levodopa/carbidopa multiparticulate matrix (Formulation 3: 484.98 ± 18.70 µg.hr/mL); Formulation 4: 535.60 ± 33.04 µg.hr/mL), and Cmax (Formulation 3: 36.28 ± 1.52 μg/mL; Formulation 4: 34.80 ± 2.19 μg/mL) were higher than Sinemet® CR (AUC0-24 262.84 ± 16.73 µg.hr/mL and Cmax 30.62 ± 3.37 μg/mL). The t1/2 of the new formulation was longer compared to Sinemet® CR.
Gestión de ventas y su impacto en la rentabilidad del concesionario Metrocar.
Authors: Arteaga Roldan Jhon Joseph , Molina de Lozano Mara
Published: October 2022

Las organizaciones requieren potenciar sus ventas para mantenerse en el mercado y contar con porcentajes de rentabilidad que le permitan ser competitivos; por tal razón, es importante analizar cómo se gestionan las ventas y la rentabilidad en una empresa con la finalidad de que agreguen valor a las metas empresariales. En este contexto, el objetivo es analizar la gestión de venta y su impacto en la rentabilidad del concesionario Metrocar. La investigación fue de tipo descriptivo con diseño no experimental transversal. Se utilizó un cuestionario diseñado en Google Forms aplicado a los ejecutivos de ventas de la empresa. Además, se utilizaron los estados financieros correspondientes a los años 2020 y 2021 obtenidos directamente del concesionario. Como principales resultados se obtuvo que, la empresa planifica las ventas realizando comparativos de cumplimiento, se establecen objetivos de ventas alcanzables cumpliendo con las proyecciones estimadas, así como también el nivel de competitividad de la empresa es considerado como satisfactorio. Por otro lado, la rentabilidad económica de la empresa y financiera muestran que los activos están produciendo rendimiento sobre la inversión, así como se han generado utilidad a favor del propietario, por otra parte, se determinó que la capacidad de convertir las ventas en utilidad no ha sido eficiente en Metrocar. Finalmente, se concluyó que la empresa mostró ventas crecientes cumpliendo con los objetivos establecidos, sin embargo, los gastos operativos fueron muy altos afectando a la rentabilidad neta, resultado de esto se declaró  0%.
Clasificación y conteo vehícular mediante análisis de imágenes.
Authors: Segarra López Juan Fernando , Cobos Torres Juan Carlos
Published: October 2022

Este trabajo propone un algoritmo capaz de analizar una muestra de video (grabación) o video en tiempo real del tránsito vehicular, el modelo final es capaz de diferenciar, clasificar y contar 3 tipos de vehículos utilizando conceptos fundamentales de inteligencia artificial y visión por computadora, con bibliotecas de código abierto; TensorFlow para la inteligencia artificial y OpenCV para la visión artificial. La metodología utilizada puede dividirse fundamentalmente en tres pasos; adquisición de datos (creando una base de datos propia con modelos de vehículos que transitan en los puntos de la ciudad utilizados para este proyecto), el desarrollo de la red (basado en un modelo de red conocido como AlexNet, una red neuronal convolucional muy utilizada en proyectos de imagen clasificación con resultados probados y confiables) y finalmente el procesamiento de la información (con una subrutina final, a través de la cual se extraen las imágenes de objetos en movimiento detectados en el video para luego contarlos y clasificarlos según su tipo). Los resultados obtenidos superan el noventa por ciento de efectividad si se contrastan con metodologías manuales, estos resultados han sido analizados en diferentes casos separados por horarios: por la mañana, por la tarde y por la noche; donde a pesar de que cambia la luminosidad y el flujo vehicular, se concluye que el modelo es robusto y puede ser llevado a producción en la industria privada o pública.
Determinants of entrepreneurial success: A comparative analysis of farm and non-farm sectors
Authors: F KOBBA , NAIN M S , SINGH RASHMI , MISHRA J R , A SHITU G
Published: October 2022

Entrepreneurship development has become the centre of many emerging economies as it is believed that entrepreneurship contributes significantly to economic growth. Quite a good number of researches have been done on factors that determine entrepreneurial success. However, the farm sector has been neglected for far too long. Present study, looked at a comparative analysis of farm and non-farm sectors in Krishi Vigyan Kendra (KVK) and Rural Development and Self Employment Training Institute (RUDSETI) to determine the factors that predict entrepreneurial success. A semi-structured interview schedule was used in 2019 to solicit information on sociodemographic and entrepreneurial characteristics from respondents. Entrepreneurs were categorized into successful and non-successful based on turnover, income and number of employees. Discriminant function analysis was used to predict the determinants of success in both farm and non-farm sectors. Results revealed that in the farm sector, four determinants of entrepreneurial success were family size, land size, turnover and annual income whereas in the non-farm sectors five determinants of entrepreneurial success were long term involvement, initiative, number of employees, entrepreneurial experience and annual income. Chi-square showed no significant difference in the success rate between farm and non-farm entrepreneurs. Policies to create the enabling environment to address access to market, market information and credit should be put in place for higher success rate of potential entrepreneurs.
Development of Quality Protein Maize based breakfast cereal
Authors: PRAKASH OM , JHA S K , RUDRA S G , JHA G K , SINHA J P , HOSSAIN FIROZ
Published: October 2022

The study was carried out at ICAR-IARI, New Delhi during 2012-16 to evaluate the effect of extrusion parameters namely, barrel temperature (100-140°C), screw speed (300-500 rpm) and feed moisture addition (6-18% wb) on quality of QPM (Var. HQPM1) based expanded extruded product. The optimum extrusion processing condition (9.75% feed moisture addition, 125°C temperature and 461 rpm screw speed) was established for QPM. At this extrusion condition, the effect of addition of finger millet and carrot powder on quality of QPM based extruded product was determined. Addition of up to 20% finger millet was found optimum for retaining acceptable colour in the extrudate. Addition of carrot powder to QPM-finger millet base imparted reddish colour to the extruded product and also led to decrease in expansion ratio and increase in bulk density. Colour (â€œa-valueâ€) increased with increase in carrot powder in the sample, indicating increase in redness of the product. Based on physical appearance of the sample, as well as expansion ratio and a-value, addition of 10% carrot powder was considered optimum. A breakfast cereal was thus developed through extrusion processing at optimum conditions using ingredients composition of 72% maize (QPM and normal maize), 18% finger millet and 10% carrot powder. The final product obtained had 9.6% protein, 1.5% fat, 3.4% fibre, 2 mg/100g Î²-carotene, 3 mg/100g iron and 122 mg/100g calcium. Amino acids (especially tryptophan and lysine) were higher in quality protein maize based product than normal maize based product.
Design and evaluation of vertical cup metering mechanism for urea briquette application
Authors: DEO MAN MOHAN , DE DIPANKAR , MANI INDRA , IQUEBAL MIR ASIF
Published: October 2022

Vertical cup feed metering device was designed and evaluated at Division of Agricultural Engineering, ICARIARI, New Delhi during 2013-14 for singulation and uniform placement of urea briquettes in two forms, viz. UB1 (3 g) and UB2 (2 g). Performance parameters like average spacing, multiple index, missing index, quality feed index and precision were measured. The metering device was tested for different cup size depth of 6.5mm (CS1), 3.5mm (CS2) and 2.5 mm (CS3) with hemi-spherical shape. The average spacing was significantly (P<0.05) influenced by different sizes of cup and sizes of briquette. Miss index was highly influenced by different cup sizes (P<0.05). The cup size (CS) influenced missing the most, followed by briquette size, but UB size did not influence missing index significantly. The briquette size influenced the multiple index most, followed by cup size of the metering mechanism (P<0.05). Quality of feed index was highly influenced by UB size, followed by CS of the metering mechanism. General mean of quality of feed index was 94.77%. The effect of urea briquette and cup size was found to be non-significant in case of precision. The general mean of precision was 13.30%. Based on the above parameters, optimum metering cup size was selected 6.5 mm and size of urea briquette UB1 for applicator development.
Playing Russian Roulette with Every COVID-19 Injection: The Deadly Global Game
Authors: Santiago Daniel
Published: October 2022

Are the promoters of the COVID-19 injections leading, pushing, and even forcing the people of the world to play a global game of Russian Roulette? The actuarial statistics and clinical facts are revealing harmful and deadly consequences on a global scale. For the sake of those still able to choose whether to spin the cylinder and pull the trigger one more time, I am conducting a guided tour. I will show why there are exponentially many more ways for the experimental injections to cause disease and death than health and well-being. Briefly put, valid transcription of mRNA from our own DNA leads to well-formed proteins that work as designed for cytoplasm, organelles, cells, tissues, and functional organ systems of the body. By contrast, the foreign (xeno) nucleic acid sequences, the mXNAs, in the “modified mRNA” in the COVID-19 injectables are more likely to harm the body’s systems than to benefit them. The relevant research shows why the mXNAs are incompetent to communicate effectively with the complex native context in vivo — the human biosignaling systems that are not mechanical but are articulated in multiple layers, interconnected, and for practical purposes, infinitely varied systems of information processing. Survival and longevity depend on valid communications among nuclear and mitochondrial DNA, their RNAs, and the protein language systems specified before a person’s birth. When these complex biosignaling systems fail, disorders and diseases follow. In catastrophic failures, death occurs. The story is not simple and the tour I am conducting is challenging with more than a few twists, turns, and digressions. However, I believe, persons experimented on — almost all of them unknowingly, some with partial knowledge who were unwilling recipients — account for more than half the world population. The stakes are high, even life or death, so I think many of the recipients of one or more injections will take the guided tour.
The Physical and Thermal Properties of Adobe Brick Containing Bagasse for Earth Construction
Authors: Lertwattanaruk Pusit , Choksiriwanna Jarunsri
Published: October 2022

A form of natural architecture built with environmentally friendly materials, earth construction provides indoor protection from outside temperature conditions. In Thailand, adobe brick that contains rice husk is the most widely used material in earth construction. It is important to consider the strength and moisture absorption capacity of adobe brick. This research focuses on the feasibility of using agricultural by-products such as rice husk and bagasse in adobe brick mixtures with a percentage replacement of 0, 1, 2, 3 and 6% by weight of materials. The study explores the level at which replacing rice husk and bagasse in adobe brick effects optimal compressive strength, shrinkage, thermal conductivity, and moisture absorption. The results provide a guideline for producing adobe brick containing agricultural by-products with improved strength and lower moisture absorption. Adobe brick with performance improved in these ways will be beneficial for developing low-cost architecture for local people and for building hotels and recreation facilities for the tourism industry.
Airflow Study for a Cluster of Campus Buildings using Different Turbulence Modeling Approaches
Authors: Davidovic Danko , Liu Jiying , Heidarinejad Mohammad , Srebric Jelena
Published: October 2022

btaining accurate numerical simulations of airflows for actual building clusters is time consuming due to a vast variety of characteristic flow patterns, combined with a wide spectrum of spatial and temporal scales. In order to provide a faster, yet reliable and simple modeling approach for simulation of outdoor airflow around multiple buildings, the presentstudy evaluated a performance of the modified zero-equation turbulence model (ZEQ). A comprehensive set of velocity field measurements in the wind tunnel experiment was conducted, and the results were used to calibrate the ZEQ model. Additional measured data are used for the validation of different turbulence modeling approaches. The performance of the modified and improved zero-equation turbulence model was compared to the revised “Kato-Launder” version of the “k-ε” model (MMK), and Large Eddy Simulations(LES) using the standard Smagorinsky Subgrid-scale model (SMG). The validation revealed a satisfactory performance of the calibrated ZEQ turbulence model in predicting streamwise mean velocity profiles, and demonstrated its comparative competitiveness with the two other turbulence modeling approaches. A less than satisfactory agreement between numerical results and measured data was identified in the prediction of vertical and lateral velocity components regardless of the turbulence modeling approach. Overall, the calibrated ZEQ turbulence model provided results that were comparable to MMK and SMG and required substantially smaller computational resources. An additional outcome of the present study is a recommendation for future research to improve performance of the calibrates ZEQ turbulence model using more advanced experimental techniques and implementation of macroscopic morphological parameters to account for realistic representation of the buildings settings in urban areas.
Public Housing Development and Low-Carbon Society Transitions: National Housing Authority’s Experiences and Applications
Authors: Wongbumru Tanaphoom , Dewancker Bart
Published: October 2022

Presently, the growing interest of a low-carbon society is widely concern on various sectors of development. Housing sector is directly associated with of climate change and it needs to be studied and explored how low-carbon society principle integrates into housing policy and practice. Particularly, affordable public housing in Thailand to low and middle-income people in the country is one prioritized solving issues. Therefore, extensive knowledge of low-carbon society concerning environs and quality of living can be incorporated into providing public housing patterns. This article presents a public housing development under National Housing Authority (NHA) of Thailand, what is initiative program of National Housing Authority has been implemented to advance low-carbon innovation in the country context. The analysis is an investigation on existing NHA’s researches and pilot projects how it contributes to achieve a low- carbon transition along with sustainable development policy.
A Field Investigation of Air Infiltration Rates through Automatic Entrance Doors in Retail Buildings
Authors: Jareemit Daranee , Shu Shi , Srebric Jelena
Published: October 2022

his paper presents field investigations of air infiltration rates in twelve big-box retail stores and two small grocery stores located in two different climate zones: hot and humid (zone 2a) and moderate to cold (zone 5a) climates. The investigations of the entrance door characteristics, differential pressures across the automatic entrance doors, and number of people using the doors per hour were used to calculate transient air infiltration rates through various types of automatic entrance doors. It was found that the calculated air infiltration rates for retail stores and supermarkets ranged from 40 L/s to 5,800 L/s. Normalized by the door area, the range of air infiltration rates through the automatic entrance door for a supermarket was from 100 L/s.m2 to 3,000 L/s.m2, which was greater than the range previously observed in retail stores from 100 L/s.m2 to 1,100 L/s.m2. In terms of air exchange rates, the air infiltration rates through the automatic entrance doors for small stores, especially in supermarkets and grocery stores, had a larger impact than those rates found in the big-box retail stores due to the size of building volume.
Public Real Estate Performance Measurement: A case studyof a Bangkok Government Complex
Authors: Riratanaphong Chaiwat , Voordt Theo J.M. van der
Published: October 2022

Various studies have shown that corporate real estate can contribute to organisational performance. However, the concept of Public Real Estate Management (PREM) has not been well known in Thailand. This paper aims to present the concept of PREM, to describe Key Performance Indicators (KPIs) that are being used in practice, to discuss KPIs that should be developed furthermore, and to explore which organisational characteristics affect the selection and prioritisation of KPIs. The empirical study is based on data from a case study of Dhanarak Asset Development Company Limited (DAD). Research methods include interviews, walk-through observations and document analysis. The findings from the case study confirm the assumed relationships between performance measurement and organisational characteristics such as organisational objectives, structure and management style. Although the DAD organisation applies a systematic performance measurement approach, it is recommended to elaborate some KPIs furthermore such as employee satisfaction with the work environment and the rate of customer retention. The findings from the case study can be used to improve the current knowledge of the impact of public real estate management on organisational perfor-mance, and to develop a holistic performance measurement system for public real estate in Thailand.
Review Article: Environmental Hazards at Home and Ergonomics as Fall Prevention for Elderly Population
Authors: Chuangchai Warawoot
Published: October 2022

This review is aimed to suggest opportunities where physiological concept may be useful to design trends to suit this rapid increase of elderly Thai population. A review of articles is presented to establish background information on the circumstance of the country which is entering the stage of becoming aging society. Also, the review provides comprehensive discussion from falls in older people to fall prevention which can be managed by interior design of the ergonomics concept. The review indicates that falls result from a complex interaction between personal factors (e.g., vision, hearing, posture, and gait) and environmental factors (environmental hazards) generating challenges and barriers related to the built environment (e.g., bathroom, built-in and loose furniture, flooring and stepping, and lighting). In this review, design recommendations which focus on bathroom function are described to promote better design integration with egonomics as a component of interior design for falls prevention strategy. Forming understanding of falls, what can increase chance of falls and what can be done as a precaution in terms of design will bring more possible opportunities to reduce the incidence, minimize chance of consequent injuries, improve overall well-being of older adults as well as possibly give inspiration on improving the quality of life.
REFORMULATION OF THE PRELIMINARY EVIDENCE AUDIT TYPE IN TAXATION: WHEN LEGAL HERMENEUTICS MEETS THE RULE OF LAW (Part 1 of 2)
Authors: Sinaga Henry D. P. , Irawan Denny
Published: October 2022

The existence of facts in the form of two pretrial decisions decided that the two preliminary evidence examinations were invalid and declared null and void. It needs to address the shift in meaning that led to this type of preliminary evidence examination. Two conclusions can be drawn based on the legal hermeneutics method, which is framed within the framework of the rule of law. First, there has been a shift in the meaning of preliminary evidence examination contained in the KUP Law, namely the existence of a closed type of preliminary evidence audit in Government Number 74 of 2011 and PMK Number 239/PMK.03/2014. This meaning can be a problem in terms of tax enforcement that must be proportional to upholding legal certainty, public benefits, and justice, and in terms of administering government administration which must be based on the principle of legality, the focus of protection of human rights, and the general direction of good governance. Second, the reformulation of preliminary evidence audit must be carried out by eliminating the prevailing type of closed preliminary evidence audit. As the understanding and explanatory side of legal hermeneutics has defined preliminary evidence examination as a series of activities carried out by preliminary evidence auditors against individuals and or entities related to circumstances, actions, and/or evidence that can provide indications of a strong suspicion that a crime in the taxation sector is being or has occurred and can cause losses to state revenue. It is necessary to delete the legal text related to the type of closed preliminary evidence audit in a secure manner.
IN SILICO EST DATA ANALYSIS OF CURCUMA LONGA: A CROSS KINGDOM APPROACH
Authors: Jha Neha , Bhatt Drushti , Patel Maulik K. , Johar Kaid , Pandya Himanshu
Published: October 2022

MicroRNAs are a newly discovered class of non-coding small RNAs with 22–24 nucleotides. They play multiple roles in biological processes including development, cell proliferation, apoptosis, stress responses and many other cell functions. In this research, several approaches were combined to make a computational prediction of potential miRNAs and their targets in Curcuma longa. The already available information of the plant miRNAs present in miRbase v21 was used against expressed sequence tags (ESTs). A total of 89 uniq miRNA were detected following a range of strict ﬁltering criteria. The target prediction was carried out for this miRNA having various targets. These targets were functionally annotated and GO terms were assigned. To study the conserved nature of the miRNAs, predicted phylogeny analysis was carried out. These ﬁndings will signiﬁcantly provide the broader picture for understanding the functions of Curcuma longa in Anti-cancer and Anti-Immunosuppressor activity.
POLLEN STRUCTURE IN SELECTED SPECIES OF MAHARAJA KRISHNAKUMASINHJI BHAVNAGAR UNIVERSITY, BHAVNAGAR DISTRICT, GUJARAT STATE, INDIA
Authors: Baroliya Hinal , Pandya Jay , Mehta Shailesh
Published: October 2022

Palynology, scientific discipline concerned with the study of plant pollen. Pollens are male reproductive cells in plants, very tiny grains produced by the stamens of flower. Pollen represents the land flora and can be used in many different disciplines. Pollen can be used to determine pollination mechanisms, therapeutic activity and source zone of pollinators. The present investigation deals with the study of pollen taxa of Twenty (20) species of Maharaja Krishnakumasinhji Bhavnagar University, Bhavnagar, and Gujarat, India. These pollen taxa belong to seventeen (17) different families. The pollen of these families has diversity in morphological characters viz, shape, attachment of filament, type of pollen and ornamentation. This study provides Palynological data of pollen taxa, which will helpful in future
PHYTOCHEMICAL PROFILE OF THE LATEX EXTRACTS OF CALOTROPIS PROCERA (AITON) DRYAND
Authors: Jayswal Misha , Rajhans Sanjukta , Mankad Archana , Pandya Himanshu
Published: October 2022

Calotropis procera (Aiton) Dryand. is a medicinal plant whose pharmacological properties are associated with its latex. In present study, aqueous and methanolic extracts of the latex were evaluated in an attempt to trace the presence of phytochemicals. The crude latex was diluted in the ratio of 1:10. The results revealed that some phytochemicals exhibited their presence in the aqueous solvent whereas some displayed their presence in the methanol. These findings provide an explanation for the use of different solvents in the experiments of phytochemical screenings.
EFFECT OF CLIMATE CHANGE ON CROP PRODUCTION IN INDIA
Authors: Nayak Pragati , Solanki Hitesh
Published: October 2022

Agriculture and climate change are deeply intertwined. Crop production is highly sensitive to climate. It is affected by long-term trends in average rainfall and temperature, inter-annual climate variability, and extreme weather events. Climate change induced increases in temperatures, rainfall variation and the frequency and intensity of extreme weather events are adding to pressures on global agricultural and food systems. Climate change is expected to negatively affect both crop and livestock production systems in most regions, although some countries may actually benefit from the changing conditions. The changing climate is also adding to resource problems, such as water scarcity, pollution and soil degradation. Climate change is likely to contribute substantially to food insecurity in the future, by increasing food prices, and reducing food production. Climate change is already affecting agriculture, with effects unevenly distributed across the world. Future climate change will likely negatively affect crop production in low latitude countries, while effects in northern latitudes may be positive or negative. Climate change will probably increase the risk of food insecurity for some vulnerable groups, such as the poor. For example, South America may lose 1–21% of its arable land area, Africa 1–18%, Europe 11–17%, and India 20–40%. To manage the impact of climate change on agriculture, careful supervision of resources like soil, water and biodiversity is required.
IN SILICO AND IN VITRO STUDIES OF ACETAZOLAMIDE AS A GAMETOCIDAL AGENT
Authors: Guleria Shivali , Momin Ayesha , V Sebastian , Menon Sudeshna , George Linz-Buoy
Published: October 2022

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Malaria remains the leading cause of mortality around the world and is the most common disease in Africa and some countries in Asia with the highest number of indigenous cases with Plasmodium falciparum responsible for the majority of the disease burden. Plasmodium has a complex life cycle consisting of multiple stages in two hosts. During the erythrocytic life cycle, it follows one of two developmental fates: terminal sexual differentiation into gametocytes or asexual propagation. Transmission from an infected human host to a susceptible mosquito is done through highly specialized sexual stages gametocytes because they are the only form of malaria parasite that are transmissible to mosquito vector, hence the discovery of new antimalarials with transmission blocking activity remains a key issue in efforts to control malaria and eventually eradicate the disease. In this study the in silico and in vitro gametocidal properties of one of the Sulfonamide drugs Acetazolamide had been checked in order to find new antiplasmodial agent. In vitro cultivation of the RKL-9 (Chloroquine resistant) strain of P. falciparum was continued to develop sexual gametocytic early stages. The drug acetazolamide was screened for gametocidal assay in order to check its transmission blocking activity by targeting early sexual stages of the parasites. Three Plasmodium falciparum proteins Pfg27, Pfs230 and PUF1were selected for molecular docking with the acetazolamide as ligand. HEX 8.0.0 server was used as docking tool and the results obtained were analysed in Discovery studio visualizer. Our findings of in vitro studies revealed that the selected drug acetazolamide possess promising gametocidal activity with IC50 = 4.812µg/ml. Hence the study can be used further for drug formulations as antimalarials targeting Gametocytic stages. Based on the in silico analysis the good binding scores -196.76, -173.87 and -193.29 (Kcal/mol) were obtained for all three selected Plasmodium falciparum proteins Pfg27, Pfs230 and PUF1 with the ligand acetazolamide respectively. Thus the docking energy results of in silico studies also supported our in vitro results that the acetazolamide can be used as an antiplasmodial drug against the gametocytes. Further studies for the mechanism of action of the acetazolamide as a gametocidal agent can be done for preventing the transmission of malaria.
HEALTH ASSESSMENT MODELING OF MANGROVES: A CASE STUDY OF PURNA ESTUARY, GUJARAT, INDIA
Authors: Jain Ankrati , Arunkumar Surisetty , Shukla Alpana , Solanki Hitesh , Chauhan H.B.
Published: October 2022

This paper quantifies the present status of Mangrove covers in the estuarine region of Purna River, Gujarat. Mangroves health assessment and change detection is modelled after contemplation of important health indicators such as canopy cover, drainage density, erosion and accretion, reclamation activities, and natural regeneration. The weightage of each parameter is given based on its relative importance in mangrove’s health. The entire study area is overlaid with a uniform grid of 1 × 1 hectare, where each parameter is calculated and mapped using multispectral LISS-IV satellite imageries of different time frames between 2008 and 2018 along with the in-situ field measurements. Our analysis showed that the mangrove area of approximately 0.094 sq.km has been degraded from 2008 to 2018 and about 0.126 sq.km has undergone degradation. Whereas the mangroves present on island patches are showing an improvement especially observed along the creek. The area under the pristine health condition of mangroves has been reduced to 0.336 sq. km. One of the major reasons was the construction of aquaculture ponds, which was increased from 2.937 sq.km in 2014 to 7.659 sq.km in 2018. The secondary factor is the wave activity near the mouth of the estuary, which is causing severe erosion along the coast and thereby affecting the mangrove trees.
A REVIEW ON HEPATOPROTECTIVE PLANTS AND COMPOUNDS
Authors: Motwani Harsha , Gadhavi Harshida , Solanki Hitesh , Patel Saumya , Rawal Rakesh
Published: October 2022

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The liver is one of the most significant organs in the body, executing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are noticeable. Due to these functions, hepatic diseases have become threat to public health, and they remain as major worldwide issue. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. Thus, it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases, with the aim of these alternatives being more effective and less toxic. The use of many herbs or their extracts for treatment of various ailments has been documented in Ayurvedic medical system. The immense potential of medicinal plants used in traditional systems has been well recognized and documented in recent years. Numerous plants and polyherbal formulations are used for the treatment of liver diseases. Phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Search for pure phytochemicals as drugs is time consuming and expensive. This review article is going to enumerate some plants with hepatoprotective properties and it is going to provide a robust insight into the phytochemistry, medicinal uses and pharmacology of a few hepatoprotective plants and their compounds. Nonetheless, further study on the phytochemistry and mechanism of action of the pure compounds are necessary to fully understand the phytochemical profile and the complex pharmacological effects of this plant.
REMOTE SENSING TREND OF FOREST ECOSYSTEM PRODUCTIVITY IN GUJARAT USING SATELLITE IMAGERY
Authors: Mohapatra Jakesh , Pandya Himanshu , Mankad Archana
Published: October 2022

Forest changes are now being rapid because of the higher rate of climatic variability. Landscape-scale evaluations of forest productivity are important to understand the response of forest species to changing climate. Net primary productivity (NPP) changes over long-term (from the year 1981 through 2006) was studied in the forest ecosystems of Gujarat state, India. The NPP product used in the study is derived from National Oceanic and Atmospheric Administration's Advanced Very High Resolution Radiometer scanner imagery by National Remote Sensing Centre, Indian Space Research Organisation. Trend analysis was done using a linear regression model in different major forest types. There was a positive trend in NPP in all forest types studied. Statistically significant (p-value < 0.05) highest trend was observed in the thorn forest (+ 1.75 g C m-2 yr-1). Increase in forest greenness indicates warming. The change in forest productivity is one of the fingerprints of climate variability.
PHYTOCHEMICAL ANALYSIS AND TOTAL TANNIN CONTENT (TTC) OF DELONIX REGIA (BOJER EX. HOOK) RAF. BARK BY USING DIFFERENT SOLVENTS COLLECTED FROM SAURASHTRA REGION
Authors: Vala Milan , Maitreya Bharat
Published: October 2022

Delonix regia (Bojer ex. hook) Raf. is belongs to Leguminosae (Fabaceae) family and Sub family Caesalpiniodeae. Usually it’s called gulmahor in Gujarati. It is used as an ornamental plant but it has some bioactive constituents which are useful in medicinal level. Delonix regia (Bojer ex. hook) Raf. is a beautiful, semi-deciduous and roadside avenue tree. It is cultivated in rural and urban area in India. It has medicinal properties such as antimicrobial and antifungal activities or as antibiotics. In this present study, qualitative and quantitative estimation of Delonix regia (Bojer ex. hook) Raf. bark from Saurashtra region. The preliminary phytochemical analysis and quantification for total tannin content was performed by using two different solvents (Acetone and Ethanol). The phytochemical analysis revealed that the presence of various phytochemicals such as phenols, tannins, flavonoids, proteins etc. Based on experiment, various bioactive constituents were present so it’s important for pharmaceutical level.
INTEGRATING BILATERAL APPROACH TO COMBAT COMBINED IIMPACTS OF HERITAGE TOURISM AND CLIMATE CHANGE
Authors: Bhatt Pathikkumar , Modi Nainesh , Pandya Himanshu
Published: October 2022

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Climate change and sustainability does not prominently manifold with respect to tourism industry within the environmental, economic and tourism policy agendas of developing countries. Evidences shows that developing countries are most vulnerable entities to the climate change. Tourism is married to good climate conditions, any attempt to divorce them could lead to danger. Tourism is considered as one of the fast-growing sectors for economy of India as it occupies 9.4% share in annual national gross development product (GDP). Since 1990s heritage is most important as well as fastest growing entity of tourism. Rankivaav (Queen’s stepwell) N23 51 32 E72 66 is a world heritage site of The United Nations Educational, Scientific and Cultural Organization (UNESCO) attracts many national and international tourists. As tourism is a growing sector it is essential to identify its promising impacts on climate change. To encounter this consequence, we tried to figure out emission of greenhouse gases by using socio-economic methods as well as establishment of the relations between sustainable development, tourism and climate change. This research suggests certain conclusion of possible relevance to climate change and sustainable developments that includes all aspects of tourism, sustainability development goals, carbon footprint, adaptation and mitigation measures, which eventually lead to the critical importance of alternative development path and assumptions about the reference case.
A REVIEW ON POTENTIAL OF MEDICINAL PLANT: LIMONIA ACIDISSIMA L.
Authors: Bhavsar Smit , Sapra Palak , Maitreya Bharat , Mankad Archana
Published: October 2022

Plant is an important source of medicine and plays a key role in achieving objectives of WHO for wellbeing of all mankind. People are getting aware about natural products, to fulfil the requirement of medicinal values, Limonia acidissima

L. of family Rutaceae, emerged out to be one of the most valuable plant owing multiple medicinal properties. The main objective of the present study is to recognize and identify different chemical constituents of the plant, which are important in the field of medicine. Hence in this article, the attempt has been made to study literature of different medicinal values, Pharmacological activities and the Ethnobotanical uses of Limonia acidissima L. The complied information of the plant can be used in various medicinal field.
FT-IR ANALYSIS OF THE CRUDE SAMPLE OF ACHYRANTHES ASPERA L. LEAVES
Authors: Qureshi Shirin , Solanki Hitesh
Published: October 2022

Achyranthes aspera L. belonging to the family Amaranthaceae commonly known as ‘Aghedo’ is an important medicinal herb found as a weed throughout India. The whole plant is of immense importance because of a wide range of pharmacological actions. Hence, the present study was undertaken to identify the functional groups present within the leaves.   The FT-IR results showed the presence of 11 peaks, which confirmed the presence of essential phytochemicals present in the crude sample of powdered A.aspera leaves.