bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise entre os condicionante climáticos e as hospitalizações por pneumonia em Manaus - Amazonas
Authors: Campos dos Santos Larissa Kristyne , Regina Aleixo Natacha Cíntia
Published: May 2023

O objetivo do estudo foi analisar a influência dos elementos climáticos e do material particulado fino (MP2,5) nas internações por pneumonia na cidade de Manaus/AM. Para isso, baseou-se no referencial teórico-metodológico do Sistema Clima Urbano, enfatizando o subsistema físico-químico, proposto por Monteiro (1976). Foram coletados, de maneira secundária, dados dos elementos climáticos no INMET, dados referentes ao MP2,5 no SISAM/INPE e dados das internações por pneumonia no DATASUS do período de 2009 a 2019, analisados com técnicas estatísticas descritivas e coeficiente de correlação de Spearman. Os resultados mostraram que a pneumonia tem sido a principal responsável pela internação da população, entre o grupo das causas de doenças respiratórias, as faixas etárias que mais sofrem com a ocorrência desta doença são os menores de 4 anos e acima de 60 anos. As internações por pneumonia possuem padrão sazonal, pois o incremento dos casos ocorrem nos meses mais chuvosos, apresentando altos índices de chuvas e umidade relativa do ar, e a diminuição das temperaturas e do MP2,5. As hospitalizações dos idosos mostraram associações estatisticamente significativas: positiva com a temperatura mínima e negativa com a umidade do ar, enquanto que as hospitalizações das crianças demonstraram associação positiva com a umidade do ar e negativa com as temperaturas e MP2,5. Neste contexto, entende-se que a relação clima e saúde são complexas e não mostram linearidade muitas das vezes, assim, é necessário incorporar o ritmo diário, priorizado em estudos voltados para uma análise geográfica do clima.
Humoral and cellular response three months following bivalent booster administration
Authors: Favresse Julien , Gillot Constant , Bayart Jean-Louis , Closset Mélanine , Wauthier Loris , Cabo Julien , David Clara , Elsen Marc , Dogné Jean-Michel , Douxfils Jonathan
Published: May 2023

Studies about the evaluation of the humoral and cellular response following the bivalent booster administration are still scarce. The aim of this study was to assess the humoral and cellular response in a cohort of healthcare workers that received either the BA.1 or the BA.4/5 bivalent booster. Blood samples from participants were collected before the administration of either the BA.1 or BA.4/5 bivalent booster from Pfizer-BioNTech and after 14, 28, and 90 days. The humoral response was evaluated using neutralizing antibodies against the BA.5 Omicron variant and binding total and IgG antibodies. The cellular response was assessed by measurement of the release of interferon gamma (IFNγ) from T cells in response to an in vitro SARS-CoV-2 stimulation. Although most participants still had a robust cellular response before the booster, a significant increase in the cellular response was observed after 2 weeks, especially in participants presenting lower levels of IFNγ before the booster administration. Levels of IFNγ remained stable at 3 months and contrast sharply with the rapid decrease of BA.5-specific neutralizing antibodies. Binding antibodies were only modestly correlated to the neutralizing capacity. The evolution of the humoral and cellular response was non-significantly different between participants that received the BA.1 or the BA.4/5 bivalent booster. The monitoring of the humoral and cellular response could be useful to identify patients with a poor adapted immunity that would need to benefit first from an additional booster shot.
Spatial-statistical analysis of lightning events in Iran
Authors: mahmoudabadi abazar esmaili , Sadeghi Farshad
Published: May 2023

The purpose of this study is to investigate the phenomenon of lightning in Iran in an eleven-year statistical period (2006–2016). For this purpose, precipitation data which included days with lightning (codes 92, 94, 95, 96, 97, 98), were extracted from other atmospheric phenomena and their spatial and temporal distribution was investigated on a monthly and yearly scale. Then, Iran was divided into 5 regions including: North and Northwest, West and Southwest, Centre, East and Northeast, South and Southeast. The obtained results showed that the highest rate of lightning activity is in stations in the north and northwest. In this region, the highest number of lightning events occur in the months of April to July and the least are in January to March. In the western and southwestern and eastern and southeastern regions, the frequency of lightning is higher in the months of March to June. But the lowest incidence is in the west and southwest region in June to September and in the east and northeast in July to December. In the central region, the spring season has the highest and September and December have the lowest occurrence of lightning. In the south and southeast region, autumn and spring have the most and June to September have the least occurrence of lightning. In general, the frequency of lightning events in the north and northwest stations is higher than in other regions of Iran. The lowest incidence of lightning phenomenon is also seen in the central parts and southeast of Iran.
Prediction of Immediate Bleeding After Cold Snare Polypectomy
Authors: Oh Shin Ju , Lee Chang Kyun , Cho Young Sin , Chung Il Kwun , Hwangbo Young , Jung Yunho
Published: May 2023

We aimed to identify risk factors and develop a predictive risk-scoring model for immediate post-polypectomy bleeding (IPPB) after cold snare polypectomy (CSP). This multicenter prospective observational study included 161 polyps (4-9 mm in diameter) that were removed via CSP from 118 patients between June and September 2019. IPPB was defined as post-polypectomy bleeding within 24 h or grade 3/4 intraprocedural bleeding requiring endoscopic hemostasis. IPPB incidences according to grade were 13.0% (21/161) (grade 3) and 0% (grade 4). Univariate analysis showed that polyp size, morphology, and iatrogenic ulcer size and shape were significantly associated with IPPB. Multivariate analysis showed that polyp size [6-9 mm vs. 4-5 mm, odds ratio (OR) 3.72, 95% confidence interval (CI) 1.28-10.79], polyp morphology (polypoid vs. non-polypoid, OR: 3.93, 95% CI: 1.22-12.64), and iatrogenic ulcer size (≥ 10 vs. ≤ 9 mm, OR: 3.12, 95% CI: 1.04-9.38) were significantly associated with IPPB. We created a four-marker risk-scoring model to predict IPPB after CSP; we summed the points assigned for the four factors. At a cut-off of 2, the sensitivity was 85.7% and the specificity was 65.0%; at a cut-off of 3, the sensitivity was 65% and the specificity was 90.0%. The four-marker risk-scoring model appears to effectively predict IPPB after CSP.
Prediction of Activity in Eyes with Macular Neovascularization Due to Age-related Macular Degeneration Using Deep Learning
Authors: Sadda Srinivas , Corradetti Giulia , Rakocz Nadav , Chiang Jeffrey , Avram Oren , Alagorie Ahmed , Nittala Muneeswar , Karamat Ayesha , Boyer David , Sarraf David , Halperin Eran
Published: May 2023

Background: To evaluate several deep learning algorithms to detect activity of macular neovascularization (MNV) using en face optical coherence tomography angiography (OCTA) images.
Methods: Choriocapillaris en face OCTA 6x6 mm images from eyes with neovascular AMD imaged with the RTvue-XR Avanti SD-OCTA (Optovue) device were included in this retrospective analysis. Multiple machine learning models were trained to classify the presence of MNV activity by OCTA imaging, using the presence of fluid on the structural OCT as the ground truth evidence for activity. Specifically, a five-fold cross-validation was applied to assess the different models’ performance.
The performance of the various models was evaluated by using the ROC and its area under the curve (AUC). A power analysis was used to assess the effect of sample size on models’ performance.
Results: 637 en face OCTA images from 97 patients were included in this analysis. We observed that en face OCTA appearance of the MNV lesion was a poor predictor of disease activity. The algorithms used did not demonstrate good performance: Resnet (0.51 [0.36,0.65]), simple CNN (0.54[0.39,0.69]), LR+PCA (0.53[0.41,0.64]), Resnet-Scratch (0.48[0.34,0.62]). We performed a power analysis to examine changes in performance as the sample size increased and saw no positive trend, suggesting that a substantial improvement in performance would not be expected with a larger sample.
Conclusions: We observed that en face OCTA images alone are poor predictors of MNV lesion activity. This suggests that strong biomarkers of disease activity may not be encoded within the en face OCTA image.
The impact of season on the dynamics of trace elements and heavy metals in shallot farming system and their human health Risk evaluation
Authors: Murniasih Sri , Santosa Sri Juari , Roto Roto
Published: May 2023

This study aims to study the effect of seasonal variations against soil physio chemical properties and to determine their effect on the absorption of trace elements and heavy metals from the soil to all parts of the shallot plants. In addition, in this study an assessment of human health risks was carried out through the consumption of shallot bulbs planted in different seasons. Analysis of heavy metal and trace element contents were carried out using the Neutron Activation Analysis (NAA) method. From the research result, it was known that seasonal differences affect soil physio chemical properties and the distribution and mobility of heavy metals and trace elements in the soil and their translocation in plants. In the rainy season, the BCF value of heavy metals in the order of Br > Na > K > Sr > Zn > Mg > Mn > Cr > Se > La > Co > Fe > As > Sc > Sm > Hf > V > Al > Rb > Ba > Th > U > Ti, while in the dry season, the order was Br > Na > K > Zn > Sr > Mg > Cr > Mn > Co > La > Sm > Sc > Fe > As > Hf > Se > V > Rb > Al > Th > Ba > U > Ti. The concentration of Mn, Sm, La, Cr, Fe, and Zn in shallots parts was in the order of roots > leaves > bulbs, while the concentration of Mg, K, Br, Na, Se, and Ba elements in the order of leaves > roots > bulbs. The risk identification and the human health risk assessment conducted to the potentially known toxic elements of U, V, Al, Mn, As, Cr, Fe, Zn, Co, Th, Ba and Sr gave target hazard quotient (THQ) and hazard index (HI) that were lower than 1 for all of them in either rainy or dry season.
Bacillus G7 improves adaptation to salt stress in Olea europaea L. plantlets enhancing Water Use efficiency and preventing oxidative stress
Authors: Galica-Campos Estrella , García-Villaraco Ana , Montero-Palmero Ma. Belén , Mañero F. Javier Gutiérrez- , Ramos-Solano Beatriz
Published: May 2023

Plants are naturally endowed with adaptative mechanisms to overcome environmental changing conditions that enable them to grow and survive in adverse conditions. In addition to these mechanisms, plants retrieve additional help from the surrounding microbiome, especially beneficial bacterial strains (PGPB) that contribute to plant fitness modulating plant physiology to fine-tune adaptation to environmental changes. The aim of this study was to explore the effects of a Bacillus strain G7 to modulate the adaptive mechanisms of Olea europaea plantlets to high saline conditions, exploring changes at the physiological, metabolic and gene expression levels. Net carbon fixation and water use efficiency (WUE) were significantly improved, resulting in significant increases in osmolytes and antioxidants while ROS scavenging enzymes were not affected, suggesting a lower oxidative stress, also supported by the high energy dissipation observed. The ABA-mediated pathway was strongly stimulated as ABA synthesis and ABA-sensing related genes were overexpressed together with a strong inhibition of repressors of ABA-response elements, as revealed by the transcriptome analysis. All these results reveal the multitargeted improvement of plant metabolism under salt stress by Bacillus G7, which allows growth under water limitation conditions, an excellent trait to develop biofertilizers for agriculture under harsh conditions.
Questionnaire research on how to train innovation stomatology undergraduates in China using domestic and international practical experiences
Authors: Ge Zhangjie , Huang Hongxin , Liu Jiayi , Li Wenhui , Li Jiamin , Wang Yifei , Tan Rongshuang , Yang Ling , Wang Chenggang , Dong Genxi , Zhang Rui , Zhou Ping
Published: May 2023

Background The curriculum of interdisciplinary oral undergraduates can help to train stomatologists with better analytical, creative and critical thinking. The curriculum reform of stomatology students is a hot topic in domestic colleges and universities.Objective The aim of this study was to (1) analyze the necessity and feasibility of setting up interdisciplinary courses through advanced cases at home and abroad and to summarize the successful experience,(2) to understand the cognition, learning interest and knowledge mastery of interdisciplinary students majoring in stomatology to lay a foundation for the formulation of training programs and development strategies for interdisciplinary innovative talents, and (3)summarize the current situation of undergraduate discipline cross-training and propose improvement measures.Methods The successful precedents of curriculum reform at home and abroad were collected, and a questionnaire on the cognition of stomatology students majoring in stomatology was designed according to the curriculum design of undergraduates in oral medicine at Lanzhou University. The results of 451 questionnaires of stomatology majors were collected, and the cognitive situation, internal mechanism, external environment and overall learning structure of interdisciplinary construction were summarized and analyzed. To achieve better reform results, we have gained experiences from the successful cases of various curriculum reforms in stomatology at home and abroad and carried out "localization" according to the actual situation. During the period, getting feedback from students helped to promote the research.Results A total of 83.6% of the respondents thought that there was a great intersection or great intersection between stomatology and other majors, and 99.8% of the respondents thought that interdisciplinary knowledge was very beneficial or relatively beneficial to the scientific research of this major. A total of 69.2% of the interviewees thought that their interdisciplinary knowledge was below average or on average, and 95.1% of the interviewees said they were very willing or more willing to learn more interdisciplinary knowledge.Conclusion It is necessary and feasible to carry out interdisciplinary education in the stage of stomatology major undergraduate education and to cultivate interdisciplinary innovative talents in stomatology. The improvement of the curriculum, the construction of an interdisciplinary cooperation base and the establishment of an interdisciplinary cooperation mode need to be further explored, expanded and deepened.
A Study of the Impact of the Covid Pandemic on the Income of the General Population of Jaipur, India
Authors: Purohit Pratiksha , Purohit Tushar , Choudhary Satender , Batwal Priyanka
Published: May 2023

The COVID-19 pandemic has emerged as a critical challenge for the current generation. One of its major implications is the adverse impact on the income of the general population. Several studies and reports have documented the significant effect of the pandemic on the earnings of individuals in both formal and informal sectors. Thus, there is an urgent need to investigate the pandemic's impact on various income groups and employment sectors, including government, private, business, professionals, and informal sectors. To explore the consequences of the COVID-19 pandemic on income levels in Jaipur, a research project was conducted. The study encompassed 211 individuals from diverse occupations and income groups to provide a comprehensive understanding of the pandemic's effect on income across different backgrounds and professions. Random sampling technique was used for data collection, and a Google form was employed to design the questionnaire and distribute it to respondents via email. Data collection took place over two months, from January to March 2023. The data collected were analyzed using SPSS software, and a chi-square test was utilized to examine the relationships between different variables. The participants were asked to provide detailed information on how the COVID-19 pandemic has affected their income and work patterns. The study's findings revealed that the impact on different occupations varied and had multiple dimensions. Therefore, policymakers should acknowledge that the pandemic's impact on income levels has not been uniform across different demographics. Consequently, policy responses should be customized to address the specific needs of distinct groups.
Psychosocial Factors Influencing Antiretroviral adherence for adolescents growing up with human immunodeficiency virus (HIV)
Authors: Awuor Silas Onyango , Mariita Courtney C. , Mariita Richard M.
Published: May 2023

Introduction: Poorer adherence to medication is very prevalent during adolescence and is among one of a range of risk-taking behaviors common during a developmental stage that encompasses enormous cognitive, physical, sexual, social and emotional change. For the youth living with human immunodeficiency virus (HIV), poor adherence to antiretroviral therapy (ART) contributes to two significant challenges: first being poor health, and the second being the risk for additional burden attributed to onward transmission to partners. Late adolescence (15–19years) is the only age group where HIV associated mortality is rising, driven by poor adherence to ART and lack of access to second line therapy, particularly amongst surviving perinatally infected youth. The aim of this study was to determine the psychosocial factors that influence adherence to antiretroviral treatment among adolescents living with HIV in Muhoroni Sub County, Kisumu, Kenya.
Methods: This was a cross-sectional study done a period of December 2021 to March 2022 that focused on the 233 active adolescents who were on HIV care within the sub county. The study was performed at the three hospital with adolescent center care (Muhoroni sub county hospital, Masogo sub county hospital and Nyangoma sub county hospital) within Muhoroni sub county hospital in Kisumu County of Kenya
Result:From the 233 adolescents 53.6% were female while 46.4% were male. There was high prevalence of HIV at the age of 18 with 75 (32.1%), followed by age 19 with 55 (23.6%), age 17 with 39 (16.7%), age 16 with 37 (15.9%) and lastly age 15 with 27 (11.6%). On drug adherence the adolescent had a good drug adherence of 86.3%, higher prevalence of depression among the female than the male under all the PHQ-9 score with 7 (3.0%) and 6 (2.6%) females having a depression of severe and moderate respectively was observed.
Conclusions: This study provides an in-depth understanding of essential factors that were possibly responsible for managing the adolescents who are care and prolonging their life too
Clinical Features and their Associations with Umbilical Cord Gas Abnormalities
Authors: Payne Allison , Wilkie Gianna , Leung Katherine , Lefwich Heidi
Published: May 2023

Objective
We seek to identify risk factors associated with abnormal umbilical artery cord gas (UACG).
Study Design
Secondary analysis of the multi-center Consortium for Safe Labor dataset. This study included singleton, term deliveries with UACG available. Abnormal UACG was defined as pH ≤ 7.0 or base excess > 12 mmol/L. Odds ratios calculated using a multivariable logistic regression to determine clinical factors associated with abnormal UACG.
Result
18 589 patients met inclusion criteria, with approximately 2% having an abnormal UACG. Those with prior Cesarean delivery (OR 1.49, 95% CI 1.15–1.93), maternal diabetes (OR 1.67, 95% CI 1.06–2.64), magnesium sulfate use (OR 1.81, 95% CI 1.25–2.60), current Cesarean delivery (OR 2.56, CI 2.06–3.19), pre-eclampsia/HELLP syndrome (OR 2.80, 95% CI 1.79–4.36), and placental abruption (OR 4.81, 95% CI 3.35–6.91) had increased odds of having abnormal UACG at delivery compared to those without.
Conclusion
Patients with certain conditions may be at increased likelihood of adverse outcomes.
WITHDRAWN: Identification and validation of aging-related genes and their classification models based on myelodysplastic syndromes
Authors: Gu Xiao-Li , Ling Zhi-Ming , Yu Li , Du Yu , Yang Xiu-Peng , xu yonggang
Published: May 2023

Background Myelodysplastic syndrome is a malignant clonal disorder of hematopoietic stem cells (HSC) with both myelodysplastic problems and hematopoietic disorders. The greatest risk factor for the development of MDS is advanced age, and aging causes dysregulation and decreased function of the immune and hematopoietic systems. However, the mechanisms by which this occurs remain to be explored. Therefore, we would like to explore the association between MDS and aging genes through a classification model and use bioinformatics analysis tools to explore the relationship between MDS aging subtypes and the immune microenvironment.Methods The dataset of MDS in the paper was obtained from the GEO database and aging-related genes were taken from HAGR. specific genes were screened by three machine learning algorithms. Then, artificial neural network (ANN) models and Nomogram models were developed to validate the effectiveness of the methods by subject operating characteristic (ROC) and decision curve analysis (DCA). Finally, aging subtypes were established and the correlation between MDS and immune microenvironment was analyzed using bioinformatics analysis tools. Weighted correlation network analysis (WGCNA) and single cell analysis were also added to validate the consistency of the result analysis.Results Seven core genes associated with ARG were screened by differential analysis, enrichment analysis and machine learning algorithms for accurate diagnosis of MDS. subsequently, two subtypes of senescent expression were identified based on ARG, illustrating that different subtypes have different biological and immune functions. And the cell clustering results obtained from manual annotation were validated using single cell analysis.Discussion Our findings emphasize the crucial role of senescence-related genes in the regulation of the immunological microenvironment. Seven hub ARGs (FOS,IKBKB,HDAC3,JUN,PTK2B,CEBPA,BAX) create a categorization model, and the findings demonstrate a key role of senescence in the immunological milieu of MDS, giving new insights into MDS pathogenesis and potential treatments. The findings show that agingplays an important function in the immunological microenvironment of MDS, giving new insights into the pathogenesis of MDS and possible immunotherapy.
Identification and physiological activity of (methoxymethyl)triphenylphosphonium chloride as a new phytotoxin isolated from Rhizoctonia solani AG-3 TB
Authors: Li Xinchun , Hou Huihui , Li Bin , Guo Shiping , Jiang Lianqiang , Xu Chuantao , Xie Yunbo , An Mengnan , Zhang Chong , Wu Yuanhua
Published: May 2023

Rhizoctonia solani as a cosmopolitan fungus is the causative agent of many crop diseases and leads to significant economic losses in crop production. To explore the toxin structure and its physiological activity of R. solani AG-3 TB, high performance liquid chromatography (HPLC), infrared absorption spectrum (IR) and nuclear magnetic resonance spectrum (NMR) were required. Here, the compound (methoxymethyl)triphenylphosphonium chloride (MMC) with the molecular formula C20H20ClOP was purified and identified from R. solani AG-3 TB. The pure compound MMC treated at 20 µg/mL, 50 µg/mL, and 100 µg/mL can cause obviously necrosis on leaves, increase active oxygen species (AOS), decrease chlorophyll content, and damage cellular structure. The results enrich the understanding of toxin compounds for R. solani as well as provide valuable insights for toxicology of R. solani AG-3 TB.
Design-driven Regional Industry Transformation and Upgrading under the Perspective of Sustainable Development: The Case of Huaihua City, China
Authors: You Lisi , Ji Tie , Shao Binbin , Wu Xiaojing , Shi Lei , Zhao Yunyan
Published: May 2023

Based on the sustainability, synergy, and systemic nature of design research, this study combines the relevant theories and methods of economics and ecology to explore design-driven transformation and upgrade paths for the sustainable development of regional industries in the context of sustainable transformation. First, the regional industrial base determines the upgrade path for sustainable transformation so that the assessment can be regarded as a prerequisite for transformation. This study uses the city of Huaihua (a prefecture-level city in Hunan Province, China) as a case study. The regional industrial base is assessed by measuring the ecological footprint, human development index, and ecological welfare performance in Huaihua City. Secondly, a mechanism for selecting leading regional industries based on quantitative data criteria was established using hierarchical analysis. As an interdisciplinary, collaborative, and systematic research method, the design study has positive implications for developing leading regional industries from the perspective of sustainable transformation. Meanwhile, as a representative region of the less developed central and western China, Huaihua City provides a theoretical basis and quantitative measurement criteria for the sustainable transformation of regional industries in the vast central and western China by designing its sustainable industrial transformation and upgrading path.
The clinical effectiveness of tolvaptan in critically ill patients with or without heart disease: A retrospective observational study
Authors: Yamazaki Yuma , Niwa Hidetomo , Ishiyama Erina , Hori Mirei , Sugo Yuki , Hirota Kazuyoshi
Published: May 2023

Background
Strategies that achieve sufficient diuresis for critically ill patients are needed. Tolvaptan, a selective arginine vasopressin 2 receptor antagonist, has increased cardiac patients' urine volume without worsening their renal function, and we speculated that tolvaptan treatment may also do so in critically ill non-cardiac patients. Here, we sought to determine whether tolvaptan treatment provided sufficient diuresis in critically ill patients including those with and without cardiac disease, without increasing their serum creatine (sCr).
Patients and Methods
We retrospectively analyzed our institution's clinical data of critically ill adult patients (n = 477) with and without cardiac disease and with an ICU stay ≥ 4 days between 2019 and 2020. We used a logistic regression model to estimate the independent predictors of critically ill patients with sufficient diuresis (which we defined as a diuretic ratio [maximal – minimal urine values]/minimal value ≥ 1), associated with seven potential confounders including tolvaptan use. We also estimated the effect of tolvaptan on time-course changes in sCr by applying a generalized estimating equation model with nine potential confounders. Each outcome was analyzed in each cohort (i.e. all patients, those with cardiac disease, and those without cardiac disease).
Results
Tolvaptan use was a significant independent predictor of patients with a diuretic ratio ≥ 1 in each cohort (odds ratio [95%CI], all patients: 2.36 [1.5–3.7], p < 0.001, cardiac patients: 2.26 [1.33–3.84], p = 0.003; non-cardiac patients: 2.63 [1.11–6.22], p = 0.0028), but it was not significantly associated with time-course changes in the sCr (beta estimator [95%CI], all patients: 0.044 [− 0.026 to 0.114], p = 0.22, cardiac patients: 0.012 [− 0.077 to 0.10], p = 0.80, non-cardiac patients: 0.085 [− 0.027, 0.20], p = 0.14).
Conclusions
Tolvaptan treatment increased the urine volume without changing sCr in critically ill adults with and without cardiac disease.
Trial registration
Not applicable.
Dosimetric study of line scanning for prostate cancer in comparison with passive scattering and volumetric modulated arc therapy
Authors: Takagi Masaru , Hasegawa Yasuhiro , Tateoka Kunihiko , Takada Yu , Hareyama Masato
Published: May 2023

Purpose
We performed a planning study to compare the dose distribution of the line scanning (LS) method with that of passive scattering (PS) method and volumetric modulated arc therapy (VMAT) for patients with localized prostate cancer.
Methods
Thirty patients treated in 2017–2019 were randomly selected. The dose constraints were the clinical target volume (CTV) D98 ≥ 73.0 Gy (RBE), rectal wall V65 < 17% and V40 < 35%, and bladder wall V65 < 25% and V40 < 50%. The CTV doses and rectal and bladder wall dose volumes were calculated and evaluated using the Freidman test. P < 0.05 was determined to be statistically significant.
Results
In all patients, the LS technique satisfied the dose restrictions for the CTV, rectal wall, and bladder wall. Ten (33.3%) and 21 (70.0%) patients using the PS method and five (16.7%) and one (3.3%) patients using the VMAT, respectively, failed to meet the requirements for the rectal and bladder walls. Wide ranges of the rectal and bladder wall volumes of V10–V70 were lower with LS than with PS and VMAT. LS was superior to VMAT in all dose-volume rectal and bladder wall indexes. PS outperformed the other two methods at Dmax.
Conclusion
Compared with PS and VMAT, the LS method enables further reduction of the rectal and bladder doses while maintaining the CTV dose. Our results suggest that proton therapy for patients with localized prostate cancer could lower gastrointestinal and genitourinary toxicities by changing from PS to LS.
Unravelling the role of adenosine A1 receptors (A1R) in toll like receptor-4 mediated neuroinflammation during sleep deprivation and recovery sleep
Authors: THONDALA BHANUTEJA , CHAUHAN GARIMA , PAWAR HARSH , RAY KOUSHIK , SHARMA MONIKA , YADAV NEHA , KUMAR SANJEEV , KISHORE KRISHNA , PANJWANI USHA
Published: May 2023

Background:
Sleep is an indispensable phenomenon in almost every organism’s life. Sleep deprivation (SD) caused by professional demands or lifestyle causing low grade neuroinflammation resulting in physiological and cognitive deficits. However, the impact of neuroinflammation on hippocampal circuitry during sleep deprivation is well-documented, but the temporal events triggering neuroinflammation during SD in the dorsal hippocampus and its effects on fear extinction memory requires further investigation.
Objectives:
We sought to examine the effect of SD on extinction memory recall and its underlying neuroinflammatory cascades in the hippocampus. We delineated the effect of Adenosine A1 receptor antagonism on TLR4 mediated neuroinflammation elicited by SD and attempted to study the effect of SD on synaptic plasticity, adult neurogenesis, apoptosis, and neuroinflammation in order to understand behavioral deficits.
Methods:
An automated customized sleep deprivation system with somatosensory stimulation was used to deprive male Sprague Dawley rats of sleep for 48 hours. Adenosine A1 receptor (A1R) antagonist [8-cyclopentyltheophylline (CPT), 12mg/kg/day, i.p.] was administered during SD and brain samples were processed for molecular analysis. Sleep architecture was recorded during baseline, SD, SD+CPT and 24h rebound sleep.
Results:
SD of 48h after extinction training induced deficits in fear extinction memory recall with a reduction in synaptic plasticity markers PSD95 (p<0.01) and Synaptophysin (p<0.01). Escalation of neuroinflammatory cytokines levels like TNFα, Nf-κB, IL-6 and activation of glial cells was observed in the hippocampal niche. Additionally, an elevation of TLR4 expression in activated microglial cells was evident after 48h SD. These results point to the involvement of A1R receptor in sleep quality, fear extinction memory recall, synaptic plasticity via blunting neuroinflammation and apoptosis in the hippocampus. There was an increase in percent alpha and delta powers in NREM and REM sleep during rebound sleep. After A1R antagonist was administered, percent of NREM, REM sleep stages and delta, theta power during sleep deprivation decreased significantly and did not increase during rebound sleep in comparison to baseline sleep.
Conclusion:
Our investigation elucidates the role of TLR4 signaling in activated microglia, which disrupts memory recall and neurogenesis. Additionally, we observed that A1R activity modulates TLR4-mediated neuroinflammation triggered by sleep deprivation, suggesting that A1Rs could represent a promising target for regulating memory impairment. Furthermore, we posit that A1Rs regulate REM sleep during sleep deprivation and govern recovery sleep architecture followed by SD.
Development of Gas Pressure Monitoring System Based on Internet of Things (IoT)
Authors: Prasetia Frabowo
Published: May 2023

LPG (Liquified Petroleum Gas) gas has a positive impact on burning gas cleaners and reduces air pollutant levels, while the negative impact is that it is more flammable in the air with high pressure. The Internet of Things (IoT) is a technology whose goal is to integrate devices into the Internet. Many previous studies have been carried out as an example on blood volume, blood pressure, and pulse monitoring devices which aim to select blood donors based on blood pressure and blood volume with external storage. The existence of an analog manometer measuring device is part of a conventional needle panel pressure measurement which could have an error in measuring the pressure. The need to use a digital manometer to properly prove gas pressure. This digital manometer can provide more accurate and detailed gas pressure information through the LCD display.
Prevalence of urinary stones in an urban population in Chile
Authors: Real Octavio Del , Arzeno Lucas , Barría Sara , Eltit Ignacio , Acuña José Ignacio , Telayna Francisco , Hassi Mario , Domínguez Raimundo , Vergara Gonzalo , Soto Guillermo , Plaza Carlos
Published: May 2023

Introduction: Urinary stone disease (USD) prevalence is highly variable worldwide, from 2.5 to 20%. This research aims to describe the prevalence and characteristics of USD in an urban population in Chile.
Methods: retrospective descriptive research based on abdominal computed tomography (CT) registries done at our hospital, between 2019 and 2020. We selected people 15 years old and older. Sample size was calculated and patients were randomly selected. Our primary outcome is to describe the characteristics of kidney stones (KS) in this population. Secondary outcomes are the prevalence of ureterolithiasis and cystolithiasis.
Results: 1,001 CT were randomly reviewed. Kidney stones were detected in 144 patients, 75 females (52.1%) and 69 males (47.9%). The estimated prevalence of nephrolithiasis was 14.4% (95%CI 12.3 - 16.7); among women was 12.7% (95%CI 10.2 - 15.8) compared to 16.7% (95%CI 13.2 - 20.6) in men. The mean age was 56.6 years old (SD 15.5). The mean number of KS per patient was 2.5, the mode was 1 KS per patient. The mean radiodensity of KS was 501 HU (SD 345.9). The mean largest diameter was 10.9 mm (SD 16.8), and the mean volume was 154.0 mm3 (SD 1,544.1). Related to KS size, 101 cases (70.1%) were 10 mm or less, 18 (12.5%) between 11 to 20 mm and 25 (17.4%) larger than 20mm. Ureterolithiasis was present in 33 cases (3.3%) and cystolithiasis in 5 patients (0.5%).
Conclusions: KS is a prevalent disease in our population, more frequent in men than women and affecting working-age people.
Satisfaction Rate of the Families of Patients Hospitalized in Intensive Care Unit with the Quality of Care: A Cross-Sectional Descriptive Study
Authors: Kalhor Leila , Nehrir Batool , Abbas Ebadi , Nouri Jamileh Mokhtari
Published: May 2023

Background Satisfaction of patients and their families is a major indicator of healthcare quality improvement. This study aimed to investigate the satisfaction of the families of the hospitalized patients and its relationship with the demographic variables of the patient and family in the intensive care unit.Methods This cross-sectional descriptive study was conducted in 2022 with the participation of 500 family members of patients hospitalized in the intensive care unit of four hospitals of Tehran. Data was collected via the completion of the modified FS-ICU24 questionnaire by a family member on third day of the patients hospitalization. Stepwise multiple regression was used to investigate the demographic factors influencing the satisfaction of the patients families.Results Families’ level of satisfaction was good with the quality of care in the intensive care unit (71%). Families were the least satisfied with meeting religious needs with an average of 3.07 (.86) and the most satisfied with respect to the patient with an average of 3.37 (.65). Also, the history of the patient’s hospitalization in the intensive care unit (P < .001), number of visits to the unit (P < .001) and the relationship with the patient (P = .024) were significantly related to family satisfaction.Conclusion There has not been enough attention to spiritual, religious, educational needs and communication with the families of patients hospitalized in the intensive care unit. Therefore, appropriate interventions are recommended to enhance satisfaction.
Towards a Scalable Proof Engine: A Performant Prototype Rewriting Primitive for Coq
Authors: Gross Jason , Erbsen Andres , Philipoom Jade , Agrawal Rajashree , Chlipala Adam
Published: May 2023

We address the challenges of scaling verification efforts to match the increasing complexity and size of systems. We propose a research agenda aimed at building a performant proof engine by studying the asymptotic performance of proof engines and redesigning their building blocks. As a case study, we explore equational rewriting and introduce a novel prototype proof engine building block for rewriting in Coq, utilizing proof by reflection for enhanced performance.
Our prototype implementation can significantly improve the development of verified compilers, as demonstrated in a case study with the Fiat Cryptography toolchain. The resulting extracted command-line compiler is about 1000× faster while featuring simpler compiler-specific proofs. This work lays some foundation for scaling verification efforts and contributes to the broader goal of developing a proof engine with good asymptotic performance, ultimately aimed at enabling the verification of larger and more complex systems.
An Adaptive Model to Reach Optimum Resources Utilization in Financial Market
Authors: Mohamed Amr Gamal , Shaaban E M , Abd-Elwaha Ahmed
Published: May 2023

A digital transformation which impact on business it going to be great from cooperate between cloud computing technologies and microservices applications impact of this assist digital transformation is the integration of technologies into all sectors of a business and can be implemented with all types of business. In this paper, we going to design an adaptive model to reach optimum resources utilization resources dynamical allocation and management is always an important feature in cloud computing which auto scale allows users to scale their cloud resources capacity according to business needs. Used experimental results to describe performance and differences between them These experimental results show the performance on market which have infrastructure setup and the graph below show read write performance this assist stockholders in business strategy in decisions scale in and scale out this strategy based on facts and that recommend suitable decision for business which help business to grow up and minimize cost without waste resources.
A Novel Prognostic Model for DLBCL Patients Based on Cuproptosis-related Genes
Authors: li fu , cai jiao , li jiali , rao jun , dong song , lin shijia , xiang xixi , Zhang Xi , Gao Li
Published: May 2023

Background: The current classification system for diffuse large B-cell lymphoma (DLBCL) cannot fully explain the prognostic differences of DLBCL patients. Cuproptosis is a newly discovered programmed cell death which depends on copper ions. In this study, a prognostic model based on cuproptosis-related genes was constructed using the public database.
Methods and materials: COX regression analysis was performed on training set-GSE31312 to construct a prognostic model based on cuproptosis-related genes, and the validation set-GSE181063 was used to verify the prognostic model. GSEA was used to explore the underlying mechanism of the difference in the prognosis of DLBCL patients. Finally, molecular docking was used to screen for compounds that may act on cuproptosis-related genes.
Results: A prognostic model based on 5 cuproptosis-related genes was constructed (CDKN2A × 1.547905713 - DLAT × 2.241073725 - DLD × 1.907442964 - LIPT1 × 2.689158994 - MTF1 × 2.069682266) from training set-GSE31312. According to this model, DLBCL patients were divided into high-risk and low-risk groups. The survival time of high-risk patients was significantly shorter than that of the low-risk group (p = 2.636 × 10-7). In the validation set GSE181063, the survival time of the high-risk group was also shorter than low-risk group (p=2.462×10-03). Among the 5 cuproptosis-related genes, only CDKN2A played a tumorigenesis effect. Finally, three small molecule compounds with the lowest binding energy of CDKN2A were found by virtual docking: Irinotecan, Lumacaftor and Nilotinib, which may be used as potential targeted drugs.
Conclusion: A prognostic model based on 5 cuproptosis-related genes was constructed, and 3 potential targeted inhibitors of CDKN2A were screened out by molecular docking.
METTL3-mediated m6A RNA methylation was involved in aluminum-induced neurotoxicity
Authors: Yang Lingling , Chen Liping , Li Wenxue , Zhang Yan , Yang Guangyu , Huang Bing , Cen Yufang , Wang Huiqi , Yang Xueqin , Lin Fangqin , Pang Yaqin , Qi Guangzi
Published: May 2023

Aluminum (Al) exposure has been linked to the development of a variety of neurodegenerative diseases. However, whether m6A RNA methylation participated in in Al-induced neurotoxicity remain to be defined. In this study, mice were administrated with aluminum-lactate at dose of 220 mg/kg. bw by gavage for 3 months. Meanwhile, the primary hippocampal neurons were isolated and treated with 0, 50, 100, 150 μM aluminum-lactate, respectively for 7 days. Al exposure caused neuronal shrinkage, decreased Nissl bodies, and increased apoptosis. In accordance, in vitro studies also showed that Alexposure led to neuronal apoptosis in a dose-dependent manner,together with the decline in m6A RNA methylation levels. Moreover, the expression of Mettl3, Mettl14, Fto, and Ythdf2 were decreased upon Al exposure. Notably, METTL3 was dramatically down-regulated by 42% and 35% in Al-treated mice and neurons, suggesting METTL3 might exert a crucial role in Al-induced neurotoxicity. We next established a mouse model with hippocampus-specific overexpressing of Mettl3gene to confirm the regulatory role of RNA methylation and found that METTL3 overexpression relieved the neurological injury induced by Al. The integrated MeRIP-seq and RNA-seq analysis elucidated that 567 genes were differentially expressed at both m6A RNA methylation and mRNA expression. Notably, EGFR tyrosine kinase inhibitor resistance, Rap1 signaling pathway, protein digestion and absorption might be involved in aluminum-induced neurotoxicity. Moreover, VEGFA, Thbs1, and PDGFB might be the central molecules.Collectively, our findings provide the novel sight into the role of m6A RNA methylation in neurodegenerative disease induced by Aluminum.
New evidence of metal exchange in Southeast Asia during the Iron Age: based on the scientific analysis of excavated bronze in Vilabouly, Laos
Authors: Yang Zishu , Jiang Zhilong , Luangkhoth Thonglith , Zhou Ranchao , Cui Jianfeng , Li Haichao
Published: May 2023

This study combines several approaches to investigate bronze objects uncovered at the Thengkham East site in Vilabouly in 2018. According to SEM-EDS research, most copper wares are binary alloys of copper and tin. Metallography (OM) studies have demonstrated that generally, the forming technique of copper wares is casting, and the microstructure of extensive annealing is shown in some areas of isolated weapons. The experimental results for this set of samples were consistent with the previously published style of Vilabouly copperware. Comparative investigations suggest that multiple sites within Vilabouly had similar metallurgical industry technology and that there is a possibility of exchanging intermediate goods between mining/ore processing sites and ordinary consuming locations. Lead isotope studies have corroborated the prevailing opinion that during the early Iron Age in Ban Non Wat, central Laos superseded Thailand in supplying copper to various sections of the Indo-China Peninsula. Given Lead isotope analysis also indicate that there had been connections between Thailand, Laos, and Cambodia in the metallurgical industry during the same period, this study provides support for the hypothesis that incorporate northeastern Cambodia into the medium-range interaction zone where central Laos is located.
On a variation of ⊕-supplemented modules
Authors: Kaynar Engin
Published: May 2023

Let R be a ring and M be an R-module. M is called ⊕ss-supplemented if every submodule of M has a ss-supplement that is a direct summand of M. In this paper, the basic properties and characterizations of ⊕ss-supplemented modules are provided. In particular, it is shown that (1) if a module M is ⊕ss-supplemented, then Rad(M) is semisimple and Soc(M) ⊴ M, (2) every direct sum of ss-lifting modules is ⊕ss-supplemented; (3) a commutative ring R is an artinian serial ring with semisimple radical if and only if every left R-module is ⊕ss-supplemented.
MSC Classification: 16D10 , 16D60 , 16D99