bluuebunny/crossref_metadata_2025 huggingface dataset:
Reforming support systems of newly diagnosed brain cancer patients: a systematic review
Authors: Loizidou Maria , Sefcikova Viktoria , Ekert Justyna O. , Bone Matan , Samandouras George
Published: November 2021

Purpose

Despite the increasing incidence of currently incurable brain cancer, limited resources are placed in patients’ support systems, with reactive utilisation late in the disease course, when physical and psychological symptoms have peaked. Based on patient-derived data and emphasis on service improvement, this review investigated the structure and efficacy of the support methods of newly diagnosed brain cancer patients in healthcare systems.

Methods

This systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. Articles from PubMed, Embase, and CENTRAL databases were screened with six pre-established eligibility criteria, including assessment within 6 months from diagnosis of a primary malignant brain tumour. Risk of bias was evaluated using the Newcastle–Ottawa Scale and Critical Appraisal Skills Program (CASP) Qualitative Studies Checklist.

Results

Of 5057 original articles, 14 were eligible for qualitative synthesis. Four studies were cross-sectional and ten were descriptive. Information given to patients was evaluated in seven studies, communication with patients in nine, and patient participation in treatment decisions in eight. Risk of bias was low in ten studies, moderate in two, and high in two.

Conclusions

Techniques promoting individualised care increased perceived support, despite poor patient-physician communication and complexity of the healthcare system. Extracted data across 14 included studies informed a set of guidelines and a four-step framework. These can help evaluate and reform healthcare services to better accommodate the supportive needs of this patient group.
The role of community pharmacists in immunisation: a national cross-sectional study
Authors: Lindner Nikolaus , Riesenhuber Martin , Müller-Uri Thomas , Weidmann Anita Elaine
Published: November 2021

Background Austrian pharmacists are not authorised to administer immunisations, and evidence about their willingness to immunise is lacking. Aim The aim of this study is to investigate Austrian community pharmacists’ willingness to administer immunisations in the future. Method This study is designed as a cross-sectional online survey based on the theoretical domains framework (TDF). The validated and piloted questionnaire obtained ethical approval by Robert Gordon University. Outcome measures included pharmacists’ willingness to immunise, service requirements, barriers and education needs. Results The questionnaire was sent out to 3086 community pharmacists of which 380 responses were included in the final analysis (12.3%). Willingness to administer immunisations after appropriate training and legislative regulation was stated by 82.6% (n = 314) of participants. It was demonstrated that pharmacists willing to immunise were significantly younger than their counterpart (38 [IQR 31–49] years vs. 45 [IQR 37.5–54] years; OR 1.06; 1.03–1.09, 95% CI; p < 0.001). ‘Legal liability’ was considered the most critical barrier to service implementation, ‘seeing blood’ and ‘close patient contact’ as least critical. Pharmacists not willing to immunise showed a higher probability to evaluate personnel resources (OR 2.98; 1.35–6.58, 95% CI; p = 0.007), close patient contact (OR 2.79; 1.46–5.34, 95% CI; p = 0.002) and management of side effects (OR 2.62; 1.21–5.67, 95% CI; p = 0.015) as (highly) critical. The majority assessed the ‘right timing for training’ to be after the foundation training with a 2-yearly renewal. Conclusion Austrian community pharmacists show a strong willingness to administer immunisations while highlighting important requirements and barriers towards service implementation.
The importance of standard operating procedures in physical fitness assessment: a brief review
Authors: Petrigna Luca , Pajaujiene Simona , Delextrat Anne , Gómez-López Manuel , Paoli Antonio , Palma Antonio , Bianco Antonino
Published: November 2021

Background

Physical fitness status is a key aspect of health and, consequently, it is important to create and adopt appropriate interventions to maintain or improve it, and assess it using valid measures. While in other testing contexts, standard operating procedures (SOPs) are commonly and widely adopted, in physical fitness testing, a variety of unstandardized testing protocols are proposed.

Aims

The topic of this review was to evaluate the existing literature on SOPs in physical fitness assessment and to provide guidelines on how SOPs could be created and adopted.

Method

The electronic databases PubMed, Web of Science and Scopus were screened and original, peer-reviewed studies that included SOPs, related to physical fitness, were recorded.

Results

After the inclusion and exclusion criteria screening, a total of six studies were included and these were critically and narratively analyzed.

Conclusions

Standard operating procedures are rarely adopted in the field of physical fitness and a step by step guide has been provided in this manuscript. In the future, it is suggested to follow protocols as a routine, because this is the only way to generalize and contextualize findings.
Exhausted due to the pandemic: Validation of Coronavirus Stress Measure and COVID-19 Burnout Scale in a Polish sample
Authors: Moroń Marcin , Yildirim Murat , Jach Łukasz , Nowakowska Justyna , Atlas Karina
Published: November 2021

This study validated Polish versions of the Coronavirus Stress Measure (CSM) and the COVID-19 Burnout Scale (COVID-19-BS) to measure stress and burnout associated with COVID-19. Participants were 431 Polish young adults (72.6% female; Meanage = 26.61 ± 12.63). Confirmatory factor analysis verified a one-factor solution for both the CSM and the COVID-19-BS. Both scales had high internal consistency reliability. Coronavirus stress and COVID-19 burnout were positively related to depression, anxiety, and stress and negatively related to resilience. The coronavirus stress and COVID-19 burnout were correlated with elevated levels of depression, anxiety, and stress over and beyond resilience, age, and gender. Findings suggest that the Polish versions of the CSM and the COVID-19-BS are valid scales to measure stress and burnout related to COVID-19. Findings also demonstrated that the coronavirus stress and COVID-19 burnout experienced during the later stages of the pandemic might be a permanent risk factor for mental health problems.
First isolation of Arcanobacterium pinnipediorum from a grey seal pup (Halichoerus grypus) in the UK
Authors: Alssahen Mazen , Foster Geoffrey , Hassan Abdulwahed Ahmed , Rau Jörg , Lämmler Christoph , Prenger-Berninghoff Ellen , Eisenberg Tobias , Robinson Mathew , Abdulmawjood Amir
Published: November 2021

In the present study, a single Arcanobacterium (A.) pinnipediorum strain isolated from discharge of a jaw swelling of a grey seal pup (Halichoerus grypus) in England, UK, was identified. This strain was further characterized by phenotypical investigations, by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), by Fourier transform infrared spectroscopy (FT-IR), and genotypically by sequencing the 16S rRNA gene and the genes gap encoding glyceraldehyde 3-phosphate dehydrogenase, tuf encoding elongation factor tu, and rpoB encoding the β subunit of bacterial RNA polymerase. The present study gives a first detailed characterization of the species A. pinnipediorum from a grey seal in the UK. However, the route of infection of the grey seal with the bacterial pathogen remains unclear.
Effectiveness and Safety of Adjustable Gastric Banding in Morbidly Obese Patients After 5 Years of Follow-up
Authors: Zurawel Robert , Gluck Marek , Piecuch Jerzy , Nowowiejska-Wiewiora Alicja , Niedziela Jacek , Wiewiora Maciej
Published: November 2021

Obesity is a civilization disease that promotes the emergence and development of many diseases, such as type II diabetes, cardiovascular, and some cancers. It directly affects the length and quality of life. The purpose of this retrospective study was to show the short- and long-term results of weight loss after laparoscopic adjustable gastric banding (LAGB) as well as to assess the results of the procedure and the percentage of reoperations. Case series analysis included 228 subsequent patients who underwent LAGB due to obesity. In the postoperative period, there was a gradual reduction in body weight, especially in the first 24 months after surgery. After 3 years, no further weight reduction was observed, and sometimes, a slight increase in weight was observed 5 years after surgery; the trend in weight reduction over the entire time period was significant. A similar result was found for percentage of BMI loss (%BMIL) and percentage of excess body weight loss (%EWL), especially in the first 36 months after surgery. Our study confirmed the good early results and low effectiveness of laparoscopic adjustable gastric banding in the long-term treatment of pathological obesity. On the other hand, the simplicity and safety of the procedure, the minimal effects of malnutrition, the low number of early complications, and the total reversibility or conversion procedure for any other bariatric surgery are the strengths of laparoscopic adjustable gastric banding for a selected group of patients.
Ooids forming in situ within microbial mats (Kiritimati atoll, central Pacific)
Authors: Suarez-Gonzalez Pablo , Reitner Joachim
Published: November 2021

Ooids (subspherical particles with a laminated cortex growing around a nucleus) are ubiquitous in the geological record since the Archean and have been widely studied for more than two centuries. However, various questions about them remain open, particularly about the role of microbial communities and organic matter in their formation and development. Although ooids typically occur rolling around in agitated waters, here, we describe for the first time aragonite ooids forming statically within microbial mats from hypersaline ponds of Kiritimati (Kiribati, central Pacific). Subspherical particles had been previously observed in these mats and classified as spherulites, but these particles grow around autochthonous micritic nuclei, and many of them have laminated cortices, with alternating radial fibrous laminae and micritic laminae. Thus, they are compatible with the definition of the term ‘ooid’ and are in fact very similar to many modern and fossil examples. Kiritimati ooids are more abundant and developed in some ponds and in some particular layers of the microbial mats, which leads to the discussion and interpretation of their formation processes as product of mat evolution, through a combination of organic and environmental factors. Radial fibrous laminae are formed during periods of increased supersaturation, either by metabolic or environmental processes. Micritic laminae are formed in closer association with the mat exopolymer (EPS) matrix, probably during periods of lower supersaturation and/or stronger EPS degradation. Therefore, this study represents a step forward in the understanding of ooid development as influenced by microbial communities, providing a useful analogue for explaining similar fossil ooids.
First extraction of eDNA from tree hole water to detect tree frogs: a simple field method piloted in Madagascar
Authors: Mullin Katherine E. , Barata Izabela M. , Dawson Jeff , Orozco-terWengel Pablo
Published: November 2021

Environmental DNA (eDNA) is becoming an increasingly used tool for monitoring cryptic species within terrestrial and aquatic systems. We present the first method for extracting water from tree holes for eDNA studies of tree-dwelling frogs, and the first use of eDNA for amphibian monitoring in Madagascar. This pilot study expands on a previously developed method and aims to provide a simple field protocol for DNA extraction from very small water samples, using a relatively inexpensive kit compared to other collection methods. We collected 20 ml of water from tree holes in Ambohitantely Special Reserve in Madagascar, with the aim to survey for the Critically Endangered tree frog Anodonthyla vallani, and we developed species specific cytochrome c oxidase 1 primers for this species. While our two samples did not detect A. vallani, we successfully extracted up to 16.6 ng/µl of eDNA from the samples and using 16S rRNA primers barcoded the tree frog Plethodontohyla mihanika in one of the samples. Despite just two samples being collected, we highlight the future potential of eDNA from tree holes for investigating cryptic habitat specialist amphibians given we extracted frog eDNA from just 20 ml of water. The method provides a rapid, simple, and cost-effective method which can assist cryptic species monitoring in challenging and time-consuming field conditions and should be developed further for frog surveying in Madagascar and beyond. The newly developed primers can be used for further work using this eDNA method to survey threatened Anodonthyla frog species.
A collective alternative to the Inward Turn in environmental sustainability research
Authors: Boda Chad S. , O’Byrne David , Harnesk David , Faran Turaj , Isgren Ellinor
Published: November 2021

It has become quite common in environmental sustainability research to promote the influencing of so-called inner dimensions of individuals as means to address pressing environmental problems such as climate change, what we refer to as the Inward Turn. We argue that the conceptual foundations of the Inward Turn, an extreme form of methodological individualism, limit it significantly as a strategy for addressing climate change and other socially relevant environmental problems. After briefly reviewing major shortcomings with the way the Inward Turn conceptualizes the relationship between individuals and social change, including its neglect of causal structures and propensity to abstract its analysis away from problems that are specific to place and time, we sketch the basic tenets of an alternative methodological approach capable of overcoming these limitations. Our approach, however, does not go to the other extreme and neglect the role of individuals; rather, our recognition of the structural drivers of particular environmental problems points to the necessity of specific collective actions by individuals, for example, in the practice of social movements. This recognition demands a rethinking of the role of individual factors, like emotion and empathy, in addressing environmental sustainability problems, namely as they relate to collective action/social movement emergence, development, and outcomes.
Upper-Body Post-activation Performance Enhancement for Athletic Performance: A Systematic Review with Meta-analysis and Recommendations for Future Research
Authors: Finlay Mitchell James , Bridge Craig Alan , Greig Matt , Page Richard Michael
Published: November 2021

Background

Research on post-activation performance enhancement (PAPE) is dominated by lower-body conditioning activities/performance test complexes. Despite the contribution of the upper body to many sporting actions, no review on upper-body PAPE currently exists.

Objectives

The aim of this systematic review with meta-analysis was to provide a synthesis of the available research on the inclusion of upper-body PAPE conditioning activities to improve athletic performance.

Methods

A review of the literature was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines, including a literature search of EBSCOhost, SPORTDiscus, PubMed and Google Scholar databases. A total of 127 studies were identified through database searches, and were assessed against the following criteria: (1) randomised controlled trial or pre-and-post study design; (2) studies explored the effects of prior voluntary muscle activity, and not electrically induced contractions, (3) evidence, or lack thereof, of PAPE was quantified by the monitoring of individual performance to commonly applied physical tests or sport-specific tasks; (4) conditioning activities and performance tests were primarily upper-body; (5) detailed description of a standardised warm-up; and (6) full-text versions of studies could be accessed in English language peer-reviewed journals. Studies were quality assessed for methodological quality via the PEDro scale and ranked accordingly.

Results

Thirty-one studies met the inclusion criteria. Studies were classified into different conditioning activity modes: bench press variations, sport-specific (modified implement throws, swing-specific, cable pulley, elastic resistance, combination) and bodyweight activity. Acute performance enhancement in several movement-specific combinations was found. A meta-analysis revealed that bench press at  ≥ 80% one repetition maximum significantly (p = 0.03; ES = 0.31) improves subsequent power output in the ballistic bench throw at 30–40% one repetition maximum, following 8–12 min recovery. Additionally, sport-specific overweight implement throws improved subsequent throwing distance at competition weight by ~ 1.7–8.5%; ES = 0.14–0.33, following 3 min recovery. Sport-specific lighter weighted bat swings and swing-specific isometrics resulted in improved subsequent competition weight bat swing velocities, ranging from ~ 1.3–4.9%; ES = 0.16–0.57.

Conclusions

This review presents several upper-body movement-specific conditioning activities that could be considered by coaches and practitioners as part of complex or contrast training, or used in pre-competition warm-ups to acutely enhance performance.
Auf dem Weg zu mehr Kollaboration: Kollaboratives Lernen als Ansatz der Lehrkräfteprofessionalisierung in der Grundbildung
Authors: Winther Esther , Paeßens Jessica , Ma Beifang , Tröster Monika , Bowien-Jansen Beate
Published: November 2021

Kollaborative Lehrkräfteprofessionalisierung ist eine wichtige Maßnahme, um Lehrkräfte zu befähigen, Herausforderungen der postpandemischen Arbeitsrealität zu bewältigen. Wie dies in der Lehrkräfteprofessionalisierung in der Grundbildung gelingt bzw. gefördert werden kann, ist bislang unzureichend erforscht. Dieser Beitrag nimmt sich dieses Desiderats an und beschreibt explorativ Gelingensbedingungen des kollaborativen Lernens im Rahmen eines Ausschnitts der kollaborativen Lehrkräfteprofessionalisierung. Hierbei wird das kollaborative Lernen entlang einer Lernspielvalidierung für die Finanzielle Grundbildung zum Gegenstand der Weiterbildung gemacht. Es zeigt sich, dass u. a. der Aufbau einer Teamorganisation, die Leitung eines Teams sowie die Aufgabenteilung innerhalb eines Teams relevant für das kollaborative Lernen von Lehrkräften sind und dass die Berufserfahrung die Beziehung zwischen der wahrgenommenen Wirksamkeit des Kollaborationsprozesses und der Entstehung des situationalen Interesses an Kollaboration moderiert.
Proof of the Bessenrodt–Ono Inequality by Induction
Authors: Heim Bernhard , Neuhauser Markus
Published: November 2021

In 2016 Bessenrodt–Ono discovered an inequality addressing additive and multiplicative properties of the partition function. Generalizations by several authors have been given; on partitions with rank in a given residue class by Hou–Jagadeesan and Males, on k-regular partitions by Beckwith–Bessenrodt, on k-colored partitions by Chern–Fu–Tang, and Heim–Neuhauser on their polynomization, and Dawsey–Masri on the Andrews spt-function. The proofs depend on non-trivial asymptotic formulas related to the circle method on one side, or a sophisticated combinatorial proof invented by Alanazi–Gagola–Munagi. We offer in this paper a new proof of the Bessenrodt–Ono inequality, which is built on a well-known recursion formula for partition numbers. We extend the proof to the result by Chern–Fu–Tang and its polynomization. Finally, we also obtain a new result.
Optimal Designs for Comparing Regression Curves: Dependence Within and Between Groups
Authors: Schorning Kirsten , Dette Holger
Published: November 2021

We consider the problem of designing experiments for the comparison of two regression curves describing the relation between a predictor and a response in two groups, where the data between and within the group may be dependent. In order to derive efficient designs we use results from stochastic analysis to identify the best linear unbiased estimator (BLUE) in a corresponding continuous model. It is demonstrated that in general simultaneous estimation using the data from both groups yields more precise results than estimation of the parameters separately in the two groups. Using the BLUE from simultaneous estimation, we then construct an efficient linear estimator for finite sample size by minimizing the mean squared error between the optimal solution in the continuous model and its discrete approximation with respect to the weights (of the linear estimator). Finally, the optimal design points are determined by minimizing the maximal width of a simultaneous confidence band for the difference of the two regression functions. The advantages of the new approach are illustrated by means of a simulation study, where it is shown that the use of the optimal designs yields substantially narrower confidence bands than the application of uniform designs.
The role of information infrastructure for climate change adaptation in the socio-ecological system of the Central Himalaya: availability, utility, and gaps
Authors: Kumar Praveen , Pandey Rajiv , Fürst Christine , Joshi P. K.
Published: November 2021

The present study intends to understand and disclose the role of information infrastructure in climate change adaptation and its underlying barriers in the communities of socio-ecological system (SES) in the Central Himalaya. The study makes use of primary data in its research methodology which comprises the use of questionnaires, oral interviews, and review of relevant literature. The data were collected using a questionnaire-based survey from 85 households in 11 villages. The study results show that road accessibility and irrigation facilities remarkably influence the educational, professional, and economic conditions of the communities. The research reveals how the flow of information through television, newspapers, village elders, and mobile phones influences perceptions of climate change in a different order. Information infrastructure availability is higher with the communities having access to the road network and irrigation facilities. The study concludes that in SES a good information infrastructure is highly relevant for reducing the current and future vulnerability of SESs to climate change. The study also provides recommendations for the dissemination of information on climate adaptation that suit the needs and demands of the Himalayan SESs and thus could help to close existing information gaps and barriers.
Small Diameter Penile Implants: A Survey on Current Utilization and Review of Literature
Authors: Campbell Scott P. , Kim Christopher J. , Allkanjari Armand , Nose Brent , Selph J. Patrick , Lentz Aaron C.
Published: November 2021

Background

Inflatable penile prostheses (IPPs) with smaller diameter cylinders have been in use for over 30 years, yet the literature is sparse on their utilization patterns amongst prosthetic surgeons.

Aim

To understand current usage of small diameter penile implants (SDPI) among prosthetic surgeons.

Methods

IRB approval was obtained to conduct a survey of prosthetic surgeons. A 23-question online survey was distributed via email to physician members of the Sexual Medicine Society of North America (SMSNA) and Society of Urologic Prosthesis Surgeons (SUPS). The survey included questions regarding surgeon experience and volume, frequency of SDPI utilization, indications for SDPI, surgical strategy in the setting of SDPI (approach, use of concordant modeling/grafting), reservoir and pump management, and perceived infection risk and patient satisfaction.

Main Outcome Measure

SDPI were utilized by the vast majority of respondents in certain clinical situations such as corporal fibrosis or anatomically small corpora, and surgeons have had a favorable experience with these as a final destination implant or as a place-holder until reimplantation with a normal diameter device.

Results

Fifty individuals responded to the survey, 48 of whom routinely utilized SDPI. The most common indication for SDPI placement was corporal fibrosis from prior infection, followed by anatomically small corpora and priapism. The most common maximal dilation diameter was 10 mm (47%), an additional 23% of respondents utilized SDPI with 11 mm dilation. 75.4% of respondents sometimes or always intended to upsize to standard diameter cylinders in the future. 68.8% of surgeons routinely counseled patients on the possibility of reduced grith and rigidity with SDPI. Patient satisfaction was perceived to be comparable to standard diameter cylinders in 56.3% of respondents, while the remaining 43.6% believed it to be lower than traditional cylinders. Utilization of SDPI can be an important tool for prosthetic surgeons faced with difficult cases due to corporal fibrosis or small corpora. This survey provides new insight into patterns of SDPI utilization by surgeons. A limitation of the study is that patient satisfaction is indirectly addressed through surgeons’ perception and experience, further research will be necessary to include patient questionnaires regarding device satisfaction.

Conclusion

SDPI are necessary in certain scenarios that preclude the use of normal diameter cylinders. These implants may offer satisfactory erections, but can also be upsized to standard diameter cylinders in the future.
Childhood absence epilepsy
Authors: Bashiri Fahad A. , Al dosari Abdullah , Hamad Muddathir H. , Kentab Amal Y. , Alwadei Ali H.
Published: November 2021

Purpose and Background:

To evaluate the electro-clinical manifestations and outcomes of children with absence epilepsy at a tertiary center in Saudi Arabia.

Methods:

This retrospective study reviewed the medical and EEG records of patients who were diagnosed to have CAE as per the International League Against Epilepsy (ILAE) definition for CAE. The study was conducted in the pediatric neurology clinic of King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia, between January 2000 and December 2019. Patients who did not meet (ILAE) criteria, lost follow-up, and those who did not receive treatment at KKUH were excluded. Data regarding the patient's disease, electro-clinical manifestations, anti-seizure medication response, and outcomes were collected.

Results:

A total of 35 patients, with an average age at diagnosis of 7 ± 2.1 y, were included in the study; among them, 51.4% were female and approximately 48.6% presented with a family history of epilepsy. Regarding clinical features, all patients experienced staring and altered awareness, 94.2% had less than 20 spells per day at the time of diagnosis, and 65.7% were provoked by the hyperventilation test. Regarding EEG findings, all patients had bilateral, symmetrical, and synchronous discharges in the form of regular 3 Hz spike-and-wave complexes, and 94.3% had a generalized initial ictal discharge. Also, 22.8% had eye fluttering with electrographic seizures. Ethosuximide (ESM) was used as the drug of choice in 45.7% of the patients. Regarding clinical outcomes, 94.3% had their disease clinically controlled, and 80% had a normalized EEG after few months of starting anti-seizure medication. Finally, 37.2% experienced complete remission of epilepsy after 3–5 y; however, one patient developed juvenile myoclonic epilepsy.

Conclusion:

This study described the electro-clinical manifestations of patients with childhood absence epilepsy and outcomes. Furthermore, early diagnosis and prompt treatment of childhood absence epilepsy improve treatment outcomes.
Introduction to Water Resources and Environmental Issues
Authors: Pennington Karrie Lynn , Cech Thomas V.
Published: November 2021

How much water does the world need to support growing human populations? What are the potential effects of climate change on the world's water resources? These questions and more are discussed in this thoroughly updated and expanded new edition. Written at the undergraduate level, this accessible textbook covers the fundamentals of water resources, water law, allocation, quality and quantity, health issues, and provides examples of potential personal actions and solutions. There is a keener focus on climate change, as many of the predictions made in the first edition have now come to pass. This new edition features improved artwork, more active learning prompts, more positive examples of beneficial changes, basic introductions to scientific approaches and a discussion of emerging contaminants and LiDAR technology. It contains strong teaching features, with new 'In Depth' and 'Think About It' sections to encourage class discussion, and homework questions to test students' understanding.
Backing as Truthmaking
Authors: Stamatiadis-Bréhier Alexios
Published: November 2021

Separatists about grounding take explanations to be separate from their corresponding grounding-facts. Grounding-facts are supposed to underlie, or back, such explanations. However, the backing relation hasn’t received much attention in the literature. The aim of this paper is to provide an informative definition of backing. First, I examine two prominent proposals: backing as explaining (Kovacs 2017; 2019a) and backing as grounding (see Sjölin Wirling 2020). Finally, I put forward my own proposal. I argue that under plausible assumptions about the role of backing and the nature of explanation, backing should be understood as a form of truthmaking, minimally construed.
On mixing enhancement by secondary baroclinic vorticity in a shock–bubble interaction
Authors: Liu Hong , Yu Bin , Zhang Bin , Xiang Yang
Published: November 2021

To investigate the intrinsic mechanism for mixing enhancement by variable-density (VD) behaviour, a canonical VD mixing extracted from a supersonic streamwise vortex protocol, a shock–bubble interaction (SBI), is numerically studied and compared with a counterpart of passive-scalar (PS) mixing. It is meaningful to observe that the maximum concentration decays much faster in a VD SBI than in a PS SBI regardless of the shock Mach number (

$Ma=1.22 - 4$

). The quasi-Lamb–Oseen-type velocity distribution in the PS SBI is found by analysing the azimuthal velocity that stretches the bubble. Meanwhile, for the VD SBI, an additional stretching enhanced by the secondary baroclinic vorticity (SBV) production contributes to the faster-mixing decay. The underlying mechanism of the SBV-enhanced stretching is further revealed through the density and velocity difference between the light shocked bubble and the heavy ambient air. By combining the SBV-accelerated stretching model and the initial shock compression, a novel mixing time estimation for VD SBI is theoretically proposed by solving the advection–diffusion equation under a deformation field of an axisymmetric vortex with the additional SBV-induced azimuthal velocity. Based on the mixing time model, a mixing enhancement number, defined by the ratio of VD and PS mixing time further, reveals the contribution from the VD effect, which implies a better control of the density distribution for mixing enhancement in a supersonic streamwise vortex.
Microlayer dynamics during the growth process of a single vapour bubble under subcooled flow boiling conditions
Authors: Sinha Gulshan Kumar , Narayan Surya , Srivastava Atul
Published: November 2021

The phenomena of microlayer formation and its dynamic characteristics during the nucleate pool boiling regime have been widely investigated in the past. However, experimental works on real-time microlayer dynamics during nucleate flow boiling conditions are highly scarce. The present work is an attempt to address this lacuna and is concerned with developing a fundamental understanding of microlayer dynamics during the growth process of a single vapour bubble under nucleate flow boiling conditions. Boiling experiments have been conducted under subcooled conditions in a vertical rectangular channel with water as the working fluid. Thin-film interferometry combined with high-speed cinematography have been adopted to simultaneously capture the dynamic behaviour of the microlayer along with the bubble growth process. Transients associated with the microlayer have been recorded in the form of interferometric fringe patterns, which clearly reveal the evolution of the microlayer beneath the growing vapour bubble, the movement of the triple contact line and the growth of the dryspot region during the bubble growth process. While symmetric growth of the microlayer was confirmed in the early growth phase, the bulk flow-induced bubble deformation rendered asymmetry to its profile during the later stages of the bubble growth process. The recorded fringe patterns have been quantitatively analysed to obtain microlayer thickness profiles at different stages of the bubble growth process. ForRe = 3600, the maximum thickness of the almost wedge-shaped microlayer was obtained asδ ~ 3.5 μm for a vapour bubble of diameter 1.6 mm. Similarly, forRe = 6000, a maximum microlayer thickness ofδ ~ 2.5 μm was obtained for a bubble of diameter 1.1 mm.
Instability of a dusty Kolmogorov flow
Authors: Sozza Alessandro , Cencini Massimo , Musacchio Stefano , Boffetta Guido
Published: November 2021

Suspended particles can significantly alter the fluid properties and, in particular, can modify the transition from laminar to turbulent flow. We investigate the effect of heavy particle suspensions on the linear stability of the Kolmogorov flow by means of a multiple-scale expansion of the Eulerian model originally proposed by Saffman (J. Fluid Mech., vol. 13, issue 1, 1962, pp. 120–128). We find that, while at small Stokes numbers particles always destabilize the flow (as already predicted by Saffman in the limit of very thin particles), at sufficiently large Stokes numbers the effect is non-monotonic in the particle mass fraction and particles can both stabilize and destabilize the flow. Numerical analysis is used to validate the analytical predictions. We find that in a region of the parameter space the multiple-scale expansion overestimates the stability of the flow and that this is a consequence of the breakdown of the scale separation assumptions.
There is no critical mass ratio for galloping of a square cylinder under flow
Authors: Han Peng , de Langre Emmanuel
Published: November 2021

The flow-induced vibration of square cylinders under flow is known to be caused by two distinct mechanisms of interaction: vortex-induced vibrations and galloping. In the present paper we address the issue of the apparent suppression of galloping when the mass ratio between the solid and the fluid is low enough. By using a reduced-order model that we validate on pre-existing results, we show that galloping is actually not suppressed, but delayed to higher values of the flow velocity. This is explained using a linear stability analysis where the competition between unstable modes is related to the transition between vortex-induced vibration and galloping. Direct numerical simulations coupled with a moving square cylinder confirm that galloping can be found even at very low mass ratios.
Nearly one-in-five mothers avoid colostrum in North Wollo Zone, Ethiopia: an institution-based cross-sectional study
Authors: Liben Misgan Legesse , Yimer Nigus Bililign , Feleke Fentaw Wassie
Published: November 2021

Colostrum contains antibodies that protect the newborn against disease. Despite this fact, many Ethiopian mothers see colostrum feeding as a cause of neonatal morbidity and mortality. These mothers believe that colostrum must discard to alleviate this effect. However, the cause of this misconception about colostrum was not well researched, particularly in this study area. The main aim of the present study was to assess colostrum avoidance and associated factors among mothers having children aged 6–59 months in North Wollo Zone, Northeastern Ethiopia. An institution-based cross-sectional study design was used. Descriptive statistics, binary and multivariable logistic regression analyses were used for the statistical analysis. The prevalence of colostrum avoidance was 19 % (95 % CI 15⋅03, 22⋅89 %) among mother–child pair aged 6–59 months. In multivariable logistic regression analysis, the most important predictors were breast-feeding initiation Adjusted Odds Ratio (AOR) 6⋅369; 95 %, Confidence Interval (CI) (3⋅067, 13⋅224), pre-lacteal feeding AOR 3⋅464; 95 % CI (1⋅721, 6⋅973), shared household decision about child feeding AOR 3⋅585; 95 % CI (1⋅563, 7⋅226), Index child sex AOR 2⋅103; 95 % CI (1⋅015, 4⋅358) and health facility delivery AOR 3⋅033; 95 % CI (1⋅293, 7⋅117). The colostrum avoidance in the present study was 19 %. The study recommends the promotion of institutional delivery, timely initiation of breast-feeding, the shared household decisions about child feeding, avoiding sex preferences and stopping pre-lacteal feeding were critically important.
Supervised classification of slush and ponded water on Antarctic ice shelves using Landsat 8 imagery
Authors: Dell Rebecca L. , Banwell Alison F. , Willis Ian C. , Arnold Neil S. , Halberstadt Anna Ruth W. , Chudley Thomas R. , Pritchard Hamish D.
Published: November 2021

Surface meltwater is becoming increasingly widespread on Antarctic ice shelves. It is stored within surface ponds and streams, or within firn pore spaces, which may saturate to form slush. Slush can reduce firn air content, increasing an ice-shelf's vulnerability to break-up. To date, no study has mapped the changing extent of slush across ice shelves. Here, we use Google Earth Engine and Landsat 8 images from six ice shelves to generate training classes using a k-means clustering algorithm, which are used to train a random forest classifier to identify both slush and ponded water. Validation using expert elicitation gives accuracies of 84% and 82% for the ponded water and slush classes, respectively. Errors result from subjectivity in identifying the ponded water/slush boundary, and from inclusion of cloud and shadows. We apply our classifier to the Roi Baudouin Ice Shelf for the entire 2013–20 Landsat 8 record. On average, 64% of all surface meltwater is classified as slush and 36% as ponded water. Total meltwater areal extent is greatest between late January and mid-February. This highlights the importance of mapping slush when studying surface meltwater on ice shelves. Future research will apply the classifier across all Antarctic ice shelves.
Validation of the INDDEX24 mobile app v. a pen-and-paper 24-hour dietary recall using the weighed food record as a benchmark in Burkina Faso
Authors: Rogers Beatrice , Somé Jérome W. , Bakun Peter , Adams Katherine P. , Bell Winnie , Carroll David Alexander , Wafa Sarah , Coates Jennie
Published: November 2021

Effective nutrition policies require timely, accurate individual dietary consumption data; collection of such information has been hampered by cost and complexity of dietary surveys and lag in producing results. The objective of this work was to assess accuracy and cost-effectiveness of a streamlined, tablet-based dietary data collection platform for 24-hour individual dietary recalls (24HR) administered using INDDEX24 platform v. a pen-and-paper interview(PAPI) questionnaire, with weighed food record (WFR) as a benchmark. This cross-sectional comparative study included women 18–49 years old from rural Burkina Faso (n 116 INDDEX24; n 115 PAPI). A WFR was conducted; the following day, a 24HR was administered by different interviewers. Food consumption data were converted into nutrient intakes. Validity of 24HR estimates of nutrient and food group consumption was based on comparison with WFR using equivalence tests (group level) and percentages of participants within ranges of percentage error (individual level). Both modalities performed comparably estimating consumption of macro- and micronutrients, food groups and quantities (modalities’ divergence from WFR not significantly different). Accuracy of both modalities was acceptable (equivalence to WFR significant at P < 0·05) at group level for macronutrients, less so for micronutrients and individual-level consumption (percentage within ±20 % for WFR, 17–45 % for macronutrients, 5–17 % for micronutrients). INDDEX24 was more cost-effective than PAPI based on superior accuracy of a composite nutrient intake measure (but not gram amount or item count) due to lower time and personnel costs. INDDEX24 for 24HR dietary surveys linked to dietary reference data shows comparable accuracy to PAPI at lower cost.
Changes in the potential distribution of the guava fruit fly Anastrepha striata (Diptera, Tephritidae) under current and possible future climate scenarios in Colombia
Authors: Amat E. , Altamiranda-Saavedra M. , Canal N. A. , Gómez-P L. M.
Published: November 2021

Climate change has affected the geographical distributions of most species worldwide; in particular, insects of economic importance inhabiting tropical regions have been impacted. Current and future predictions of change in geographic distribution are frequently included in species distribution models (SDMs). The potential spatial distributions of the fruit fly Anastrepha striata Schiner, the main species of agricultural importance in guava crops, under current and possible future scenarios in Colombia were modeled, and the establishment risk was assessed for each guava-producing municipality in the country. SDMs were developed using 221 geographical records in conjunction with nine scenopoetic variables. The model for current climate conditions indicated an extensive suitable area for the establishment of A. striata in the Andean region, smaller areas in the Caribbean and Pacific, and almost no areas in the Orinoquia and Amazonian regions. A brief discussion regarding the area's suitability for the fly is offered. According to the results, altitude is one of the main factors that direct the distribution of A. striata in the tropics. The Colombian guava-producing municipalities were classified according to the degree of vulnerability to fly establishment as follows: 42 were high risk, 16 were intermediate risk, and 17 were low risk. The implementation of future integrated management plans must include optimal spatial data and must consider environmental aspects, such as those suggested by the models presented here. Control decisions should aim to mitigate the positive relationship between global warming and the increase in the dispersal area of the fruit fly.
Radiation necrosis of the bone, cartilage or cervical soft-tissues following definitive high-precision radio(chemo)therapy for head-neck cancer: an uncommon and under-reported phenomenon
Authors: Gupta T , Maheshwari G , Gudi S , Chatterjee A , Phurailatpam R , Prabhash K , Budrukkar A , Ghosh-Laskar S , Agarwal J P
Published: November 2021

Background

The impact of modern high-precision conformal techniques on rare but highly morbid late complications of head and neck radiotherapy, such as necrosis of the bone, cartilage or soft-tissues, is not well described.

Method

Medical records of head and neck cancer patients treated in prospective clinical trials of definitive high-precision radiotherapy were reviewed retrospectively to identify patients with necrosis.

Results

Twelve of 290 patients (4.1 per cent) developed radiotherapy necrosis at a median interval of 4.5 months. There was no significant difference in baseline demographic (age, gender), disease (primary site, stage) and treatment characteristics (radiotherapy technique, total dose, fractionation) of patients developing radiotherapy necrosis versus those without necrosis. Initial management included antibiotics or anti-inflammatory agents, tissue debridement and tracheostomy as appropriate followed by hyperbaric oxygen therapy and resective surgery for persistent symptoms in selected patients.

Conclusion

Multidisciplinary management is essential for the prevention, early diagnosis and successful treatment of radiotherapy necrosis of bone, cartilage or cervical soft tissues.
Patterns of care for octogenarian patients with head and neck cancer
Authors: Iqbal M S , Navarro-Rodriguez C , Munro S , Ozalp B , Kelly C
Published: November 2021

Objective

To examine the patterns of care for octogenarian head and neck cancer patients.

Methods

All newly diagnosed patients aged 80 years or older, who presented at our centre between June 2018 and October 2020, were included.

Results

The total number of patients was 42. The median Charlson Comorbidity Index was 5 (range, 4–9). The larynx was the most common subsite (n = 12). Twenty-nine patients (66 per cent) were diagnosed at disease stage IV. Squamous cell carcinoma was the most common histology (86 per cent). Twenty-six patients (62 per cent) had radical treatment and 16 (38 per cent) had palliative treatment. The estimated six-month and one-year overall survival rates for the radical and palliative treatment cohorts were 92.3 per cent and 42.9 per cent (p = 0.001) and 65.4 per cent and 15.4 per cent (p = 0.003), respectively.

Conclusion

This study provides useful information on octogenarian patients with head and neck cancer. This information may help in conducting prospective studies, especially those focusing on older patients with head and neck cancer, in order to define the ideal care of this patient population.
Homeward bound: A lifelong quest for a sense of belonging
Authors: Siu Helen F. , Leung Angela Ki Che
Published: November 2021

‘Does home have to be a country or a city?… Or is home this house or that? We have been fortunate. … We seemed always to have been home.’
Unilateral declarations excluding bilateral relations under a multilateral treaty
Authors: Gaja Giorgio
Published: November 2021

Bilateral relations between states which are parties to a multilateral treaty may not be governed by that treaty. This may depend on an agreement between the two states concerned, which could subject their bilateral relations to a different regime that is considered to suit their specific needs better. The exclusion of bilateral relations under the multilateral treaty may also be the consequence of a unilateral expression of the will of one of these states, for instance in view of its non-recognition of the other state. The present article seeks to examine the conditions under which bilateral relations may be excluded on the basis of the unilateral determination of one of the states concerned.
Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study
Authors: Öberg Jonas , Rasmussen Magnus , Buchwald Pamela , Nilson Bo , Inghammar Malin
Published: November 2021

This study aimed to describe the incidence ofStreptococcus bovis/Streptococcus equinuscomplex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies wasS. gallolyticussubsp.pasteurianus88/236 (37%) followed byS. gallolyticussubsp.gallolyticus58/236 (25%). In order to determine the risk of cancer following bacteremia, an incidence cohort of 174 episodes without a prior diagnosis of CRC or metastasised cancer was followed for 560 person-years. CRC was found in 13/174 (7%), of which 9 (69%) hadS. gallolyticussubsp.gallolyticus-bacteremia. In contrast to other European studies,S. gallolyticussubsp.pasteurianuswas the most common cause of SBSEC-bacteremia. CRC diagnosis after bacteremia was strongly associated withS. gallolyticussubsp.gallolyticus-bacteremia. Identification of SBSEC subspecies can guide clinical decision-making regarding CRC work-up following bacteremia.