bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of donor-specific antibodies in lung transplantation
Authors: Brandon William , Dunn Colin , Bollineni Srinivas , Joerns John , Lawrence Adrian , Mohanka Manish , Timofte Irina , Torres Fernando , Kaza Vaidehi
Published: September 2023

The formation of antibodies against donor human leukocyte antigens poses a challenging problem both for donor selection as well as postoperative graft function in lung transplantation. These donor-specific antibodies limit the pool of potential donor organs and are associated with episodes of antibody-mediated rejection, chronic lung allograft dysfunction, and increased mortality. Optimal management strategies for clearance of DSAs are poorly defined and vary greatly by institution; most of the data supporting any particular strategy is limited to small-scale retrospective cohort studies. A typical approach to antibody depletion may involve the use of high-dose steroids, plasma exchange, intravenous immunoglobulin, and possibly other immunomodulators or small-molecule therapies. This review seeks to define the current understanding of the significance of DSAs in lung transplantation and outline the literature supporting strategies for their management.
Atg8ylation as a host-protective mechanism against Mycobacterium tuberculosis
Authors: Deretic Vojo
Published: September 2023

Nearly two decades have passed since the first report on autophagy acting as a cell-autonomous defense against Mycobacterium tuberculosis. This helped usher a new area of research within the field of host-pathogen interactions and led to the recognition of autophagy as an immunological mechanism. Interest grew in the fundamental mechanisms of antimicrobial autophagy and in the prophylactic and therapeutic potential for tuberculosis. However, puzzling in vivo data have begun to emerge in murine models of M. tuberculosis infection. The control of infection in mice affirmed the effects of certain autophagy genes, specifically ATG5, but not of other ATGs. Recent studies with a more complete inactivation of ATG genes now show that multiple ATG genes are indeed necessary for protection against M. tuberculosis. These particular ATG genes are involved in the process of membrane atg8ylation. Atg8ylation in mammalian cells is a broad response to membrane stress, damage and remodeling of which canonical autophagy is one of the multiple downstream outputs. The current developments clarify the controversies and open new avenues for both fundamental and translational studies.
How Does the Jumping Performance Differs between Acrobatic and Rhythmic Gymnasts?
Authors: Leite Isaura , Goethel Márcio , Conceição Filipe , Ávila-Carvalho Lurdes
Published: October 2023

An increased jumping performance is key for gymnastics competition routines. Rhythmic gymnasts (RGs) use the jump as one of the main body elements. In Acrobatic Gymnastics (ACRO), top gymnasts must coordinate their jumps with the impulse provided by base gymnast(s). It is expected that the gymnasts’ discipline and role played impact their jumping skill. This work aims to investigate how the jumping performance differs between ACRO gymnasts and RGs, focusing on the Force–Velocity (F-V) profile mechanical variables. Gymnasts were divided in three groups: ACRO tops (n = 10, 13.89 (3.62) median (interquartile interval) years old), ACRO bases (n = 18, 18.24 (4.41) years old) and RGs (n = 15, 12.00 (3.00) years old). The F-V profile during countermovement jump and its mechanical variables were evaluated using MyJump2. A training background survey and anthropometric assessments were conducted. The significance level was set at p ≤ 0.05. Group comparisons showed that ACRO bases jump higher than ACRO tops and RGs, present a higher maximal force than RGs and a more balanced F-V profile, while RGs present high force deficits. Coaches can use this data to develop interventions that optimize the training stimulus to different gymnastics disciplines considering the individual characteristics and adaptability of each gymnast.
Pomegranate Cultivars with Diverse Origins Exhibit Strong Resistance to Anthracnose Fruit Rot Caused by Colletotrichum gloeosporioides, a Major Disease in Southeast United States
Authors: Schaller Alexander , Chater John M. , Vallad Gary E. , Moersfelder Jeff , Heinitz Claire , Deng Zhanao
Published: October 2023

Pomegranate, a pivotal fruit that is well recognized globally and a rapidly emerging crop in the southeastern United States and other subtropical regions, faces a formidable challenge from Colletotrichum spp., a fungal pathogen causing anthracnose fruit rot, which leads to severe to complete premature fruit drop. The development and use of disease-resistant cultivars are considered the most cost-effective and sustainable approach to managing this disease. Identifying sources of resistance is essential for developing new cultivars with improved resistance to this disease. This project aimed to expand the scope of evaluation through a 2-year field study in central Florida, examining fruit from 35 cultivars from diverse origins using both artificial inoculation at the petal dehiscent stage and natural infection. Lesion size on the fruit was measured during the growing season in a field setting. Subsequently, seven cultivars were selected for further testing by inoculating detached mature fruit and measuring lesion size to confirm observed resistance and determine the correlation between resistance observed in planta in the field and on detached fruit in the laboratory. The field study revealed significant genetic differences among pomegranate cultivars in susceptibility to naturally occurring and induced anthracnose fruit rot and classified cultivars into five resistance or susceptibility classes. Five cultivars that originated from different regions of the world, including ‘Azadi’, showed consistent resistance to anthracnose fruit rot in the field. Resistance remained strong on detached mature fruit. A strong positive correlation existed between resistance levels on in-planta fruit and on detached mature fruit, suggesting a possible simple, efficient approach to screening breeding populations for anthracnose fruit rot resistance in pomegranate. These findings represent an important step toward developing new anthracnose-resistant cultivars and understanding and improving disease resistance in this increasingly important fruit crop in the world.
Comparative Analysis of the Fatty Acid Profiles of Antarctic Krill (Euphausia superba Dana, 1850) in the Atlantic Sector of the Southern Ocean: Certain Fatty Acids Reflect the Oceanographic and Trophic Conditions of the Habitat
Authors: Murzina Svetlana A. , Voronin Viktor P. , Bitiutskii Dmitry G. , Mishin Aleksej V. , Khurtina Svetlana N. , Frey Dmitry I. , Orlov Alexei M.
Published: October 2023

The present study is the attempt to combine oceanologic measurements and biochemical analysis, which is as possible to implement on board as in a laboratory with chosen certain statistics to reveal trophic conditions and the environment state in which Antarctic krill live in season in real time on site. The fatty acid constituents of total lipids in juvenile and mature Antarctic krill sampled from the Bransfield Strait (BS), the Antarctic Sound (AS), and waters at the eastern tip of the Antarctic Peninsula (AP) collected during the 87th cruise of the R/V Akademik Mstislav Keldysh in January–February 2022 were analyzed. The fatty acid (FA) profile in juvenile and mature Antarctic krill was studied by gas chromatography with a mass selective detector to identify the qualitative composition and a flame ionization detector to quantify the studied FAs. Using NMDS analysis (quantitative panel), great difference was found between krill from the BS compared to krill collected in the AS and the AP. The differences are reliable owing to the following 16 FAs, most of them trophic biomarkers of microphytoplankton, and suggest regional differences, mainly in abundance and ability of forage objects. CTD measurements discuss the abiotic factors (potential temperature, salinity, and chlorophyll “a”). Compensatory modifications of the composition of FA components in Antarctic krill inhabiting different water areas are a way of maintaining the species’ viability under certain and variable habitat conditions.
Pricing European Vulnerable Options with Jumps and Stochastic Default Obstacles Barrier under Regime Switching
Authors: Liu Xiangdong , Zhang Zanbin
Published: October 2023

In this paper, we propose an enhanced model for pricing vulnerable options. Specifically, our model assumes that parameters such as interest rates, jump intensity, and asset value volatility are governed by an observable continuous-time finite-state Markov chain. We take into account European vulnerable options that are exposed to both default risk and rare shocks from underlying and counterparty assets. We also consider stochastic default barriers driven by a regime-switching model and geometric Brownian motion, thus improving upon the assumption of fixed default barriers. The risky assets follow a related jump-diffusion process, whereas the default barriers are influenced by a geometric Brownian motion correlated with the risky assets. Within the framework of our model, we derive an explicit pricing formula for European vulnerable options. Furthermore, we conduct numerical simulations to examine the effects of default barriers and other related parameters on option prices. Our findings indicate that stochastic default barriers increase credit risk, resulting in a decrease in option prices. By considering the aforementioned factors, our research contributes to a better understanding of pricing vulnerable options in the context of counterparty credit risk in over-the-counter trading.
The Method of Choosing Parameters for Margin Trading Protocols in the Constant Product Model
Authors: Kovalchuk Lyudmila , Kostanda Volodymyr , Marukhnenko Oleksandr , Kuchynska Nataliia , Marchuk Yuliia
Published: October 2023

We introduce a new method of choosing parameters for margin trading protocols in the Constant Product Model and apply it to our new DeFi Margin Trading protocol Primex, which can work with different DEXs and DeFi platforms. The main advantages of Primex, in comparison with existing DeFi protocols, are the following: (1) the possibility to trade with leverage, using large asset amounts and having only a small part (deposit) in one of the assets; (2) full explanation and justification of the choice of protocol parameters and relations (such as liquidation condition, maximum leverage, different fees, etc.), which allows to estimate different risks (for Lenders and the protocol) and reduce them to the required level; (3) additional decentralization and, at the same time, protection against different faults in protocol functioning, achieved by the usage of the decentralized Keeper; (4) transparent rules and conditions for all participants—Lenders, Traders, and Keepers. We give a detailed explanation for our approach to set protocol parameters and build a corresponding method to obtain their numerical values in the case of the Constant Product Model. The obtained numerical results provide additional indirect confirmation of the consistency of our method. Note that it also may be applied (after the corresponding recalculation of some coefficients) to other models, such as the Order Book Model, Constant Sum Model, or the Mixed Constant Sum/Constant Product Model (as described in the Curve whitepaper), and even other types of DeFi protocols after some modification.
In Silico Studies of Four Compounds of Cecropia obtusifolia against Malaria Parasite
Authors: Lobato-Tapia Carlos Alberto , Moreno-Hernández Yolotl , Olivo-Vidal Zendy Evelyn
Published: October 2023

Malaria is a disease that affects many people in the world. In Mexico, malaria remains an active disease in certain regions, particularly in the states of Chiapas and Chihuahua. While antimalarial effects have been attributed to some species of Cecropia in various countries, no such studies have been conducted in Mexico. Therefore, the objective of this study was to evaluate the in silico antimalarial activity of some active compounds identified according to the literature in the species of Cecropia obtusifolia, belonging to the Cecropiaceae family, such as ursolic acid, α-amyrin, chrysin, and isoorientin. These compounds were evaluated with specific molecular docking and molecular dynamics (MD) studies using three different malarial targets with the PDB codes 1CET, 2BL9, and 4ZL4 as well as the prediction of their pharmacokinetic (Pk) properties. Docking analysis revealed the following best binding energies (kcal/mol): isoorientin–1CET (−9.1), isoorientin–2BL9 (−8.8), and chrysin–4ZL4 (−9.6). MD simulation validated the stability of the complexes. Pharmacokinetics analysis suggested that the compounds would generally perform well if administered. Therefore, these results suggest that these compounds may be used as potential drugs for the treatment of malaria.
Further Quinolizidine Derivatives as Antiarrhythmic Agents- 3
Authors: Tasso Bruno , Mattioli Laura Beatrice , Tonelli Michele , Boido Vito , Chiarini Alberto , Sparatore Fabio , Budriesi Roberta
Published: October 2023

Fourteen quinolizidine derivatives, structurally related to the alkaloids lupinine and cytisine and previously studied for other pharmacological purposes, were presently tested for antiarrhythmic, and other cardiovascular effects on isolated guinea pig heart tissues in comparison to well-established reference drugs. According to their structures, the tested compounds are assembled into three subsets: (a) N-(quinolizidinyl-alkyl)-benzamides; (b) 2-(benzotriazol-2-yl)methyl-1-(quinolizidinyl)alkyl-benzimidazoles; (c) N-substituted cytisines. All compounds but two displayed antiarrhythmic activity that was potent for compounds 4, 1, 6, and 5 (in ascending order). The last compound (N-(3,4,5-trimethoxybenzoyl)aminohomolupinane) was outstanding, exhibiting a nanomolar potency (EC50 = 0.017 µM) for the increase in the threshold of ac-arrhythmia. The tested compounds shared strong negative inotropic activity; however, this does not compromise the value of their antiarrhythmic action. On the other hand, only moderate or modest negative chronotropic and vasorelaxant activities were commonly observed. Compound 5, which has high antiarrhythmic potency, a favorable cardiovascular profile, and is devoid of antihypertensive activity in spontaneously hypertensive rats, represents a lead worthy of further investigation.
pH and NaCl Optimisation to Improve the Stability of Gold and Silver Nanoparticles’ Anti-Zearalenone Antibody Conjugates for Immunochromatographic Assay
Authors: Shahjahan Thasmin , Javed Bilal , Sharma Vinayak , Tian Furong
Published: October 2023

The aim of this research is to define optimal conditions to improve the stability of gold and silver nanoparticles’ anti-zearalenone antibody conjugates for their utilisation in lateral flow immunochromatographic assay (LFIA). The Turkevich–Frens method was used to synthesise gold nanoparticles (AuNPs), which were between 10 and 110 nm in diameter. Silver nanoparticles (AgNPs) with a size distribution of 2.5 to 100 nm were synthesised using sodium borohydride as a reducing agent. The onset of AuNP and AgNP aggregation occurred at 150 mM and 80 mM NaCl concentrations, respectively. Stable Au and Ag nanoparticle–antibody conjugates were achieved at 1.2 mM of K2CO3 concentration, which corresponds to the pH value of ≈7. Lastly, the highest degree of conjugation between Au and Ag nanoparticles and anti-zearalenone antibodies was at 4 and 6 µg/mL of antibody concentrations. The optimisation of the conjugation conditions can contribute to better stability of nanoparticles and their antibody conjugate and can improve the reproducibility of results of bioreporter molecules in biosensing lateral flow devices.
Neuromuscular Response during Different Side-Cutting Maneuvers and Its Influence on the Risk of Knee Injuries
Authors: Feria-Madueño Adrián , Hewett Timothy E. , Sánchez-Arteaga Alejandro , Sañudo Borja
Published: October 2023

Background: The objective of this study was to investigate the impact of a customized exercise program on electromyographic (EMG) variables during side-cutting maneuvers. Methods: Fifty-seven physically active volunteers were recruited and randomized into two groups: a control group (CG) and an experimental group (EG). The CG maintained their regular physical activity, while the EG followed an individualized, integrated exercise regimen that included strength, neuromuscular, proprioceptive, eccentric training, and whole-body vibration (WBV) exercises, lasting for 12 weeks. EMG-Root Means Square (RMS) values for the quadriceps (Q) and hamstrings (H) were measured immediately following initial foot contact at 50, 100, 150, and 200 milliseconds. Changes in EMG activity were evaluated before and after a twelve-week intervention, and the effect size (ES, 90% confidence limit [90%CL]) was calculated. Results: The results showed that the EG participants exhibited enhanced co-contraction as measured by the hamstring/quadriceps ratio (H/Q ratio) during both open and cross-cutting side maneuvers after the twelve-week intervention. Conclusion: Furthermore, the customized, integrated exercise program that combined strength, neuromuscular, proprioceptive, eccentric training, and WBV exercises were could potentially serve as a beneficial neuromuscular and biomechanical strategy for addressing knee injury risk in non-professional, physically active populations at high risk for such injuries.
“Does Physical Exercise Promote Health Benefits for Diabetic Patients during the COVID-19 Pandemic?”: A Systematic Review
Authors: Souza Erivaldo de , Meneses-Santos Daniela , Santos Josué Cruz , Aidar Felipe J. , Carvalho Carla Roberta de Oliveira , Santos Jymmys Lopes dos , Marçal Anderson Carlos
Published: October 2023

Patients affected by COVID-19 are prone to facing disorders in multiple systems and organs, which can lead to deleterious diseases; in addition, people with pre-existing diseases may be more prone to the worst outcomes, and the most vulnerable are patients with type 1 and type 2 diabetes mellitus. The aim of this systematic review was to evaluate the effects of physical activity and/or physical exercise prescribed to individuals with diabetes on the maintenance of plasma glucose and glycated hemoglobin during the COVID-19 pandemic. Studies were found by searching PubMed, SCOPUS, Embase, Web of Science, SciELO, LILACS, SportDiscus, Bireme/BVS and Google Scholar databases. The inclusion criteria were articles that addressed only patients with type 1 or type 2 diabetes (T1D and T2D) who had evaluated the level of physical activity or physical exercise and described the effects on plasma glucose and/or glycated hemoglobin in cross-sectional, retrospective, and observational studies, meeting the main criteria established by GRADE. The PICO and GRADE strategies were used to select and assess the methodological quality of studies. Two reviewers searched and selected the articles in databases independently and blindly, during which oppositions and disagreements about the inclusion of articles were discussed and resolved by a third reviewer. Evidence corroborates that levels of physical activity were reduced due to the lockdown, leading to increased body weight and worse glycemic control. On the other hand, individuals with diabetes mellitus (DM) (T1D and T2D) who maintained and/or increased levels of physical activity or physical exercise showed reduced plasma glucose and glycated hemoglobin (HbA1c) levels. Adequate levels of physical exercise and physical activity are beneficial for glucose and HbA1c control in diabetic patients (type 1 or type 2). In addition, maintaining adequate levels of physical activity can contribute to reducing health problems when these patients are infected with COVID-19.
Outcomes of Hip Arthroscopy in Patients with Systemic Inflammatory Diseases: A Matched Cohort 5-Year Follow-Up Study
Authors: Rynecki Nicole D. , Shankar Dhruv S. , Morgan Allison M. , Kouk Shalen , Youm Thomas
Published: October 2023

The purpose of this study was to determine if there is a difference in hip survivorship rates and patient-reported outcomes (PROs) at a 5-year follow-up after arthroscopic treatment of femoroacetabular impingement syndrome (FAIS) between patients with versus without systemic inflammatory diseases (SIDs). A retrospective single-surgeon matched cohort study of FAIS patients who underwent hip arthroscopy and had a minimum of a 5-year follow-up was conducted. Subjects with SIDs were matched at a ratio of 2:3 of age and body mass index (BMI) with respect to controls without SIDs. Subjects completed the modified Harris Hip Score (mHHS) and Non-Arthritic Hip Score (NAHS) prior to surgery and at a 2-year and 5-year follow-up. Survival distributions for time to reoperation and to total hip arthroplasty (THA) were compared between groups using the log-rank test. Fifteen subjects with SIDs (mean age 41.5 years) were matched with twenty-five controls (41.8 years). There were no significant differences in reoperation rates (SIDs 27% vs. controls 20%, p = 0.71) or THA conversion rates (SIDs 7% vs. controls 12%, p = 1.00) at the 5-year follow-up, nor were there differences in survival distributions for reoperations (p = 0.72) or THAs (p = 0.55). There were no significant differences in postoperative mHHS (SIDs 79.3 vs. controls 88.5, p = 0.09) or NAHS (SIDs 82.7 vs. controls 89.3, p = 0.77) by the 5-year follow-up. At the 5-year follow-up, FAIS patients with comorbid SIDs experienced a significant clinical improvement from hip arthroscopy that is comparable to that of FAIS patients without SIDs.
Implementation of a Transportable Radar Mode S of Monopulse Secondary Surveillance (MSSR-S) for the Peruvian Civil Aviation Surveillance
Authors: Vidal Luis. , Concha Ulises , Solís Justo , Piedra José , Chávez Carlos , Cano Dominga , Woolcott Juan
Published: October 2023

This article describes the process of implementing a transportable radar MSSR-S for Peruvian civil aviation (ACP) to minimize the operational impact in emergencies that affects air traffic without causing structural damage and restore data from the radar in a short time. In recent years, ACP has shown constant falls in the radars, causing radar data to be lost for long periods of time and putting air safety at risk due to the lack of maintenance and overlapping radar coverage of more than three radars. The deployment of the transportable radar in Mode S of Monopulse Secondary Surveillance (MSSR-S) has allowed for work that involves the prolonged stoppage of the radar to be carried out and provided coverage to eight more radars during maintenance and modernization, covering the areas without coverage in the Peruvian air space (EAP). For the implementation, this was divided into three SPRINTs using the SCRUM methodology; the first sprint refers to the equipment and radar coverage study, the second the implementation and service test phase, and the third the operational analysis phase with the eight modernized radars. As a result of the implementation and integration with the other ACP radar systems, they were able to operate together, providing highly reliable radar data, performing a continuous analysis of radar performance through the PASS software, complying with the thresholds established by ICAO and EuroControl, and guaranteeing that the systems operate under perfect conditions and with full coverage at all time.
Retail trade in Russia — optimization of financial costs and increase in profi ts during the crisis
Authors:   Federal State Budgetary Educational Institution All-Russian Children's Center ", Pivovarova Elena Vladimirovna ,   Orlyonok",   , Tuapse District, Krasnodar Region
Published: October 2023

The scientifi c article presents the results of the analysis of retail trade in Russia and indicates some of the problems of the industry and their solutions. The article shows the current and promising strategies for optimizing fi nancial costs in the retail trade, which helps to increase the economic effi ciency of entrepreneurial activity. The main trends in the development of retail trade in the Russian economy are determined. The theoretical foundations of the concept of "fi nancial costs" are considered. The author's algorithm for the strategy of optimizing fi nancial costs in the retail business is proposed. Recommendatory measures have been developed to optimize fi nancial costs while ensuring an increase in the economic efficiency of entrepreneurial activities of small and medium-sized retail enterprises. The relevance of the scientifi c research on this issue is due to the fact that the economic efficiency and competitiveness of small and medium-sized businesses in the retail trade of the Russian economy depend on the eff ectiveness of fi nancial cost management. Thanks to the implementation of a high-quality strategy for optimizing fi nancial costs, an increase in cost-eff ectiveness and profi tability of entrepreneurial activities in the trading business is ensured. The object of the study is small and medium-sized enterprises in the retail trade. The subject of the study is the fi nancial costs in the Russian retail business.
Import and Export of Capital from Russia under Sanctions and Response Measures
Authors:   Institute of Economics of the Russian Academy of Sciences, Moscow, Kvashnina I. A.
Published: September 2023

The article deals with external sanctions and Russia’s response in connection with the conduct of a special military operation. The subject of the study is mutual measures to restrict the movement of capital, their adjustment by the Russian side as the economy adapts. Particular attention is paid to the problem of the withdrawal or suspension of activities of foreign companies in Russia: the initial scale of the exodus and their possible consequences are assessed, strategies for the behavior of foreign investors are given, as well as response measures from the Russian government in order to protect the economic interests of the country. It is noted that under the current conditions, Russian business is also forced to sell and regroup its foreign assets, look for new markets and stock platforms to place its securities and invest in foreign ones. An analysis of the balance of payments of the Russian Federation for 2022 indicates a sharp reduction in accumulated liabilities. At the same time, the outflow of capital from the private sector continued, amounting to a record 10 % of GDP, which is a deduction from the country’s investment potential. In conclusion, the consequences and risks for the Russian economy from the adoption of mutual restrictions on the cross-border movement of capital are indicated. Including: an increase in the volatility of the ruble due to a decrease in the infl uence of the fi nancial account, as well as the withdrawal of funds abroad from the sale of foreign assets; an increase in the debt burden on the corporate sector; falling stock market liquidity; problems with enterprise management and reconfiguration of technological processes after the transition to Russian owners, etc.
Prospects for Russian Gas in China for the Period until 2035
Authors:   Institute of Economics of the Russian Academy of Sciences, Moscow, Kondratov D. I.
Published: September 2023

The article presents an analysis of the current state and forecasts for the longterm development of the Chinese natural gas market, as well as the prospects for increasing Russian supplies of fossil fuels to this market. It is expected that by the end of 2030 China can catch up and overtake Europe in terms of gas consumption. By 2030, the total demand for gas in China will be 390–560 billion cubic meters. m, which is almost 1.5 times higher than in 2022. During the period of economic slowdown, the imbalance of supply and demand in the global hydrocarbon market leads to its destabilization. In order to predict such situations in advance, specialists from international and Russian organizations (International Energy Agency, BP plc, Energy Research Institute of the Russian Academy of Sciences, Institute of Energy Economics of Japan) and consulting companies (IHS Markit) periodically prepare papers on the evolution of world energy markets and the consequences for major countries. gas consumers. Almost all studies are not yet ready to name the period of peak demand for gas in China in the foreseeable future, which gives grounds to name the 21st century of gas transformation. In this article, a study was made of the Chinese gas market and an analysis of the factors of the longterm dynamics of demand for this energy resource. The author also made an attempt to assess the expansion of our country’s participation in the Chinese gas market, and prepared interim recommendations on using the potential for developing energy cooperation between China and Russia. At the same time, the northeastern provinсes of China, located near the Russian border, after the launch of the Power of Siberia gas pipeline, will be saturated with Russian gas. At the same time, the insufficient development of gas infrastructure — pipeline capacities, gas storage facilities, distribution networks — in China will not allow increasing exports when Russia builds additional capacities. To an even greater extent, this applies to the Power of Siberia — 2 gas pipeline project. The most promising way to increase Russian gas exports to China is the organization of Russian LNG supplies to the coastal regions of China, where a steady growth in gas demand is predicted.
MOBILE HEALTH DAN EFEKTIVITASNYA TERHADAP AKTIVITAS FISIK REMAJA: LITERATUR REVIEW
Authors: Fitriani Fitriani , Mulyono Sigit
Published: September 2023

Regular physical activity has many benefits for adolescents in the immediate and long-term. The high rate of obesity and low participation from adolescents in regular physical activity require strategies for lifestyle changes. The development of technology and innovation in health technology provides a strategy for increasing behavior change with smartphone applications (mHealth). This review aimed to identify the effectiveness of mHealth intervention strategies for facilitating physical activity among adolescents. The method used is the systematic search for literature review in electronic databases such as ProQuest, PubMed, Google Scholar, ClinicalKey Nursing, Scopus, SpringerLink and ScienceDirect with keywords mHealth and physical activities and adolescent” “smartphone apps and physical activities and adolescent” and “mobile applications and exercise and adolescent” on the years range 2018 to 2022. Only nine articles were kept for analysis from 1.861 articles found. This study states that mHealth has a positive effect on adolescent physical activity. The significant level of positive effect depends on the type of application used. Health workers can recommend mHealth as an intervention to increase adolescents’ physical activity.
Trotes em instituições militares
Authors: Nicolau Filho Mario Sergio
Published: October 2023

O presente trabalho foi produzido com base em um estudo sobre a realização de trotes em instituições militares diversas. No Paraná o ingresso ocorre na Polícia Militar, através das escolas de formação de praças policiais militares (CFP) e na escola de formação de oficiais policiais militares (CFO) aos quais possuem núcleos de formação espalhados por diversas localidades do Paraná. Nestes locais são especificamente onde os recém ingressos, receberão os ensinamentos da doutrina e hierarquia militar. Porém a fim de evitar exageros e improvisos por parte dos responsáveis pela formação, serão analisados alguns fatos ocorridos em outras instituições militares que poderiam ter sido evitados ou mitigados, os quais ocorreram na realização de trotes violentos ou ritos de inicialização considerados vexatórios ou impróprios e tornaram-se público através de matérias difundidas nas mídias jornalísticas sobre trotes em organizações militares. Bem como ao final serão apresentadas sugestões para que tais ações não sejam adotadas na Polícia Militar do Paraná.  A metodologia utilizada foi a pesquisas bibliográfica, documental e exploratória, com a devida qualificação dos dados coletados, com objetivo de propiciar  maior estreiteza com um problema apresentado através da análise de exemplos e buscando desta forma alternativas para solução do problema, visando assim a melhor especialização dos profissionais de segurança pública da PMPR para sociedade paranaense.
Síndrome de Klinefelter: uma abordagem diagnóstica, evolução clínica e revisão
Authors: Pidde Arthur Gomes , Dos Santos Gabriella Nunes de Magalhães , Santos Kelven Duarte , Cordeiro Ana Clara Reis de Oliveira , De Oliveira Paulo Vitor Lellis Paiva , da Silva Erika Machado Rodrigues , Barreto Gabriela Porto , Rodrigues Marianna Maksoud , Belai Gabriel Mazuchini , Santos Gabriela Rita de Sousa , Tomé Tábata Maia , Martins Darkyelle Ibiapina , Souza Juliana Lima de Oliveira , De Araújo Vitor Brandão , Eserian Ana Luiza Delgado , Vieira Ana Carolina Monge
Published: September 2023

Introdução: Os pacientes portadores da Síndrome de Klippel-Feil possuem uma anomalia congênita rara caracterizada pela clássica tríade: pescoço curto e alado, limitação dos movimentos cervicais e baixa implantação da linha do couro cabeludo. Sendo característico a fusão de duas ou mais vértebras cervicais. Vale salientar que a síndrome está associada a outras doenças e também a malformações cardíacas ou do trato geniturinário. Apresentação do caso: M.F.S., um jovem de 20 anos, residente em Goiânia, Goiás, foi encaminhado para uma consulta médica devido a preocupações manifestadas por seus pais. Eles notaram que Mateus tinha um ritmo de crescimento mais lento em comparação com seus colegas de idade, além de apresentar algumas características físicas atípicas. Mateus sempre teve dificuldades em se integrar socialmente e também enfrentou obstáculos em sua jornada acadêmica. Para compreender melhor essa situação, seus pais buscaram avaliação médica. Discussão:  O diagnóstico diferencial é de grande importância clínica como condrodisplasia, Síndrome de Wildervanck, Síndrome de Down, Síndrome de Turner, Síndrome de Noonan e pterygium colli. O tratamento se baseia no diagnóstico e na abordagem das doenças associadas e a existência ou a possibilidade de causa de déficit neurológico podem indicar a necessidade de cirurgia. Conclusão: É imprescindível, portanto, salientar que os pacientes com estenose de canal medular podem sofrer um risco mais aumentado de lesões medulares a traumatismos leves, com quadros mais graves de tetraplegia ou subluxações. Vale ressaltar que é necessário a investigação de outras doenças congênitas e normalmente pacientes diagnosticados podem apresentar sintomas neurológicos que levam as queixas de algia cervical crônica, compressão medular e radicular.
Síndrome de Capgras: uma abordagem diagnóstica, evolução clínica e revisão
Authors: De Castro Bernardo Taveira , Ribeiro Drielly Nunes , Queiroz Ícaro de Lima , Martins Jessica Fernanda Ferreira , Branquinho Igor Vieira , De Sá Rebbeca Musy Almeida , Leitão Waldeir de Sousa , Arrighi Bárbara Barcelos , Lima Bruna Mara Bessa , Poschinger Alessandra Krykhtine Peres , Macêdo Rayhume Karylle Alves
Published: September 2023

Introdução: A Síndrome de Capgras é um distúrbio psiquiátrico raro e intrigante, classificado como uma síndrome delirante, em que o indivíduo acredita que uma pessoa próxima, geralmente um membro da família ou amigo íntimo, foi substituída por um impostor idêntico. Essa condição foi descrita pela primeira vez pelo psiquiatra francês Jean-Marie Joseph Capgras em 1923. Apresentação do Caso: L.M.P., uma mulher de 38 anos, natural do estado de Goiás e com um diagnóstico de base de transtorno de ansiedade, foi admitida em um hospital psiquiátrico aproximadamente cinco semanas após sofrer um acidente de carro. A paciente foi levada ao hospital por sua filha, pois apresentava alucinações auditivas e visuais. De acordo com relatos da filha, inicialmente, a paciente não conseguia identificar seu marido, expressando desconforto com sua presença na casa e insistindo que ele era um impostor. A gravidade da situação escalou com múltiplos episódios em que L.M.P. agrediu fisicamente o marido, alegando que estava sendo ameaçada por ele. Este comportamento era específico em relação ao marido e não se manifestava em interações com outros membros da família. Discussão: Os pacientes podem demonstrar emoções neutras ou negativas em relação ao suposto impostor e podem se tornar paranóicos e desconfiados. A causa exata da Síndrome de Capgras parece estar relacionada a disfunções em áreas do cérebro responsáveis pelo reconhecimento facial e pelas emoções. Fatores neurológicos, psicológicos e genéticos podem estar envolvidos. Seu diagnóstico é baseado na história clínica, exame psiquiátrico detalhado e descarte de outras condições médicas ou psiquiátricas. O tratamento da Síndrome de Capgras envolve abordagens terapêuticas, incluindo psicoterapia, terapia cognitivo-comportamental e uso de medicamentos antipsicóticos, se necessário. Conclusão: A Síndrome de Capgras continua a ser uma fonte de fascinação e aprendizado, incentivando pesquisas futuras e abrindo caminhos para novos insights sobre a riqueza da experiência humana e a intrincada complexidade do cérebro e da mente.
Síndrome de Costello: uma abordagem diagnóstica, evolução clínica e revisão
Authors: Borba Amanda Cristina Gomes , Ribeiro Paulo Victor Spindola , Guimarães Marcelo Nunes , Daher Heitor Campos Damião , Ferreira Larissa David , Carvalho Ana Beatriz , Dy Lucena Thallita Alves , Quintanilha Heloisa Ganassini , Oliveira Maria Eduarda Hummel , Akasaka Giuliana Mayumi Neves , Ahmed Nara Gomes , Duarte Bruna Stylita , Rocha Isadora Gonçalves
Published: September 2023

Introdução: Síndrome de Costello (SC) é uma doença congênita, com padrão autossômico dominante, decorrente de mutações no gene HRAS, situado no cromossomo 11p15, sendo considerada extremamente rara. Apresenta-se com manifestações craniofaciais grosseiras, déficit de crescimento, retardo no desenvolvimento psicomotor, anomalias cardíacas, endócrinas e esqueléticas. Apresentação do caso: Paciente do sexo masculino, 6 anos, residente em uma área urbana de Goiânia, Goiás, foi encaminhado para avaliação cardiológica em um hospital local com diagnóstico prévio de cardiomiopatia hipertrófica e manifestações clínicas associadas à Síndrome de Costello. Ele é filho de pais não consanguíneos e saudáveis, sem histórico de doenças genéticas na família. Nasceu de parto cesáreo com 37 semanas de gestação, pesando 3400 gramas, sem complicações pré-natais. Discussão: Apesar da síndrome de Costello manifestar características clínicas marcantes, as mesmas não são patognomônicas. O diagnóstico é complexo, sendo esse um conjunto de achados clínicos, fenotípicos e estudos genéticos, pois tal síndrome faz parte de um grupo amplo de síndromes neuro-cardio-facio-cutâneas, apresentando, então, alguns diagnósticos diferenciais a serem descartados. Conclusão: Dessa forma, obter um diagnóstico precoce da síndrome proporciona uma melhor investigação das complicações, acompanhamento e condutas a serem estabelecidas ao paciente.
Síndrome de Crouzon: uma abordagem diagnóstica, evolução clínica e revisão
Authors: Dy Lucena Thallita Alves , Quintanilha Heloisa Ganassini , Oliveira Maria Eduarda Hummel , Akasaka Giuliana Mayumi Neves , Ahmed Nara Gomes , Duarte Bruna Stylita , Rocha Isadora Gonçalves , Borba Amanda Cristina Gomes , Ribeiro Paulo Victor Spindola , Guimarães Marcelo Nunes , Daher Heitor Campos Damião , Ferreira Larissa David , Carvalho Ana Beatriz
Published: September 2023

Introdução: A craniossinostose é uma doença congênita decorrente de uma anormalidade por fechamento prematuro de suturas cranianas. Pode se manifestar de maneira isolada ou associada a outras características, configurando síndromes genéticas. A Síndrome de Crouzon consiste em um dos mais comuns exemplos de síndromes genéticas associadas à craniossinostose. Apresentação do Caso: Um menino de 4 anos, residente no estado de Goiás, foi levado pela mãe a um consultório pediátrico por apresentar anormalidades faciais perceptíveis desde o nascimento. A mãe descreveu que o menino tinha um formato atípico do crânio, olhos excessivamente afastados e um nariz largo e chato. Além disso, ela notou que o desenvolvimento da linguagem do filho estava visivelmente atrasado em relação a outras crianças da mesma faixa etária. Discussão: A Síndrome de Crouzon é uma doença genética autossômica dominante, causada por mutações no gene FGFR2 (receptor 2 do fator de crescimento de fibroblastos) que resultam em ativação do receptor e desenvolvimento inadequado das suturas cranianas. Além disso, a síndrome clínica inclui proptose ocular, hipoplasia maxilar, estrabismo e outros distúrbios faciais. O diagnóstico consiste na avaliação clínica, história familiar e exames de imagem, permitindo a identificação das suturas cranianas fechadas precocemente. O tratamento é multidisciplinar e individualizado, conforme diversas variáveis: idade do paciente, gravidade dos sintomas e presença de complicações. A intervenção cirúrgica frequentemente é necessária, tanto a liberação das suturas cranianas quanto correção de proptose ocular e estrabismo. Conclusão: A Síndrome de Crouzon é uma doença responsável por anormalidades craniofaciais congênitas. As avaliações clínico-laboratoriais com genética molecular permitem uma melhor abordagem da síndrome juntamente às equipes multidisciplinares.  Os avanços em pesquisa e discussões entre especialistas podem contribuir para melhor compreensão e definição do tratamento dessa síndrome.
Síndrome de Kartagener: uma abordagem diagnóstica, evolução clínica e revisão
Authors: Quirino Isadora Cristina Pires , Cunha Rafael Magalhães , Del Fiaco Larissa Godoy , Miguel Moabe , Calvoso Beatriz de Souza , Bueno Luciana Cação Vilela , Panini Victoria de Oliveira , Xavier Isabel Macedo , Cardoso Leticia Lacerda , Guimarães Thaís Silva , Vargas Renata Gabriela
Published: September 2023

Introdução: A Síndrome de Kartagener (SK) pertence a um subgrupo da discinesia ciliar primária (DCP), causada por uma doença autossômica recessiva rara, que se manifesta pela tríade de bronquiectasias, pansinusite crônica e situs inversus com dextrocardia. Uma pequena porcentagem dos pacientes pode apresentar hidrocefalia.  Apresentação do caso: JLSG, sexo masculino, 5 anos de idade, natural de Goiânia, Goiás. A mãe possui histórico de asma, enquanto o pai relata vários episódios de rinossinusite desde o nascimento. Durante a consulta pediátrica, a mãe menciona que, no período pós-neonatal, a criança foi internada seis vezes devido a pneumonia. Foram solicitados diversos exames, incluindo laboratoriais, tomografia computadorizada de tórax, audiometria e videonasofibroscopia que confirmaram o diagnóstico. Discussão: O diagnóstico da SK é tardio em muitos casos, devido o quadro clínico ser semelhante com as infecções das vias aéreas superiores (sinusite e otite média), e inferiores (pneumonias de repetição e bronquiectasias). Sendo de extrema importância a realização do diagnóstico precoce, com história clínica completa, exames complementares e diagnósticos diferenciais com outras síndromes, evitando as possíveis complicações da doença. O tratamento objetiva a prevenção de lesões pulmonares crônicas, infecções e bronquiectasias. E consiste na realização de limpeza das vias aéreas com solução salina hipertônica, principalmente, associada a fisioterapia respiratória contínua; antibioticoterapia, de forma empírica ou de acordo com os patógenos encontrados na cultura e no antibiograma; drenagem de seios da face, que pode beneficiar os pacientes com sinusite grave que não respondem a antibioticoterapia; além da eliminação do tabagismo e evitar o contato com poluição exacerbada. Conclusão: Os portadores da SK geralmente apresentam bom prognóstico, com a expectativa de vida semelhante às pessoas não acometidas. No entanto, pode haver óbitos em neonatos, em indivíduos com diagnóstico tardio ou que não seguem o tratamento clínico adequado. Ou seja, o prognóstico depende do diagnóstico precoce e do acompanhamento clínico apropriado.
Síndrome de Pelizaeus-Merzbacher: uma abordagem diagnóstica, evolução clínica e revisão
Authors: Da Silva Arianny Lima , Miguel Gabriel Cezar de Araujo , Reisdorfer Verônika Carazzai , Bogaski Luana Rafaela Saldanha , De Castro Victória Leoni Pardi , Arenzon Brenda Etges , Nunes Carolina Caetano de Araujo , Aoyagi Amanda Mayumi , Da Silva Isabele Ferreira , Martins Amanda de Almeida , Ribeiro Camilo de Lelis Lobo , Vieira Yasmin de Amorim , Cardoso Lara Caroline , Domingues Matheus Mendonça , Branco André Lages Gonçalves Castelo
Published: September 2023

Introdução: O desenvolvimento infantil saudável depende de inúmeros fatores, dentre eles, a adequada mielinização neuronal na formação de sinapses nervosas. Desta forma, doenças da substância branca representam um obstáculo no campo da neurologia no que tange a garantia de um diagnóstico precoce e manutenção de terapêuticas adequadas para cada paciente. Apresentação do Caso: Um menino de 3 anos, nascido em Anápolis, estado de Goiás, filho único de pais não aparentados, veio ao mundo por meio de um parto cesáreo sem complicações. Na ocasião, pesava 2.800 gramas, media 50 centímetros e tinha um perímetro cefálico de 36 centímetros. Este paciente foi submetido a uma consulta pediátrica para acompanhamento de um retardo no desenvolvimento que tinha se tornado aparente a partir dos 8 meses de idade. Discussão:  Neste contexto, a Síndrome de Pelizeaus-Merzbacher (SPM) é um tipo de leucodistrofia hipomielinizante de etiologia genética, caracterizada pela deficiência na produção ou manutenção da mielina. Os principais sintomas da Síndrome de Pelizaeus-Merzbacher incluem atraso no desenvolvimento motor, espasticidade, ataxia, distúrbios visuais e déficits cognitivos. O diagnóstico é geralmente baseado na história clínica, exame neurológico, exames de imagem, como a ressonância magnética cerebral, e testes genéticos para identificar mutações no gene PLP1. A confirmação diagnóstica é realizada por biologia molecular. Conclusão: Não há cura para a Síndrome de Pelizaeus-Merzbacher, e o tratamento visa, principalmente, o controle dos sintomas e o suporte multidisciplinar, para melhorar a qualidade de vida dos pacientes.