bluuebunny/crossref_metadata_2025 huggingface dataset:
Spike selection in SARS-CoV-2 variants across different geographical regions reveals unique signature patterns and differential stability with drug interaction
Authors: Liya Devang Haresh , Anand Nithishwer Mouroug , Jainarayanan Ashwin Kumar , Elanchezhian Mirudula , Seetharaman Madhumati , Balakannan Dhanuush , Pradhan Arpit Kumar
Published: March 2022

The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus since its emergence in 2019 has yielded several new viral variants with varied infectivity, disease severity, and antigenicity. Although most mutations are expected to be relatively neutral, mutations at the Spike region of the genome has shown to have a major impact on the viral transmission and infection in humans. Therefore, it is crucial to survey the structures of spike protein across the global virus population to contextualize the rate of therapeutic success against these variants. In this study, high-frequency mutational variants from different geographic regions were pooled in order to study the structural evolution of the spike protein through drug docking and MD simulations. We investigated the mutational burden in the spike sub regions and have observed that the different variants harbour unique signature patterns in the spike sub regions, with certain domains being highly prone to mutations. Further, the MD simulations and docking study revealed that different variants show differential stability when docked for the same set of drug targets. This work sheds light on the mutational burden and the stability landscape of the spike protein across the variants from different geographical regions.
Anharmonic Coupling of Stretching Vibrations in Ice: A Periodic VSCF and VCI Description
Authors: Schireman Raymond , Maul Jefferson , Erba Alessandro , Ruggiero Michael
Published: March 2022

The anharmonicity of O-H stretching vibrations of water ice is characterized by use of a periodic implementation of the vibrational self-consistent field (VSCF) and vibrational configuration interaction (VCI) methods, which take phonon-phonon couplings explicitly into account through numerical evaluation of high-order terms of the nuclear potential. The low-temperature, proton-ordered phase of water ice (namely, ice-XI) is investigated. The net effect of a coupled anharmonic treatment of stretching modes is not just a rigid blue-shift of the respective harmonic spectral frequencies but rather a complex change of their relative spectral positions, which can not be captured by simple scaling strategies based on harmonic calculations. The adopted techniques allow for a hierarchical treatment of anharmonic terms of the nuclear potential, which is key to an effective identification of leading factors. We show that an anharmonic independent-mode approximation only describing the "intrinsic anharmonicity" of the O-H stretches is unable to capture the correct physics and that couplings among O-H stretches must be described. Inspection of harmonic normal coordinates allows to identify specific features of the O-H stretching motions which most likely enable strong mode-mode couplings. Finally, by coupling O-H stretches to all other possible modes of ice-XI (THz collective vibrations, molecular librations, bendings), we identify specific types of motion which significantly affect O-H stretching states: in particular, molecular librations are found to affect the stretching states more than molecular bendings.
Using stochastic hierarchical aggregation constraints to nowcast regional economic aggregates
Authors: Koop Gary , McIntyre Stuart , Mitchell James , Poon Aubrey
Published: March 2022

Recent decades have seen advances in using econometric methods to produce more timely and higher-frequency estimates of economic activity at the national level, enabling better tracking of the economy in real time. These advances have not generally been replicated at the sub–national level, likely because of the empirical challenges that nowcasting at a regional level presents, notably, the short time series of available data, changes in data frequency over time, and the hierarchical structure of the data. This paper develops a mixed– frequency Bayesian VAR model to address common features of the regional nowcasting context, using an application to regional productivity in the UK. We evaluate the contribution that different features of our model provide to the accuracy of point and density nowcasts, in particular the role of hierarchical aggregation constraints. We show that these aggregation constraints, imposed in stochastic form, play a key role in delivering improved regional nowcasts; they prove to be more important than adding region-specific predictors when the equivalent national data are known, but not when this aggregate is unknown.
Coverage of the Interim Amur Government and Supporters of the Soviet Power Activities in the Kamchatka Region (Based on the Materials of “Kamchatsky listok” Newspaper 1922)
Authors:   Petropavlovsk Branch of Russian Presidential Academy of National Economy and Public Administration, Pasechnik А. F.
Published: March 2022

Based on the materials of “Kamchatsky listok” newspaper (1922), the author reveals the peculiarities of the formation of a positive image of the Interim Amur government and discrediting the supporters of the Soviet power in the Kamchatka region on the pages of this newspaper. Newspaper materials show that the establishment of the power of the Interim Amur Government in Kamchatka took place exclusively in a peaceful way. Special emphasis is placed on the legality, patriotism and humanity of the acting government, as well as the support of the government by the Kamchatka population. The author also revealed the peculiarities of presenting information material on the newspaper pages depicting opponents of the acting government (members of the former regional revolutionary committee and members of partisan groups). To create a negative image and discredit them, a significant amount of published information was devoted to the illegality of the regional revolutionary committee in power, the small number of supporters of Soviet power and the criminal methods of their actions. In order to increase the effectiveness of the emotional impact on readers, such a technique as the publication in the news-paper of acute negative personal characteristics of the Kamchatka Bolsheviks, which took on caricature forms, was widely used. The publications of “Kamchatsky listok” are interesting from the point of view of the analysis of the official interpretation of current political events and unique factual data that cannot be found in any other sources.
Barnaul School for Studying the History of Entrepreneurship at the Turn of 20th – 21st Centuries
Authors:   Altai State Technical University, Klimova O. G.
Published: March 2022

The article is devoted to the formation and development at the turn of the 20-21 cen-turies of the Barnaul Scientific School studying the history of entrepreneurship in pre-revolutionary Siberia. Modern historiography has accumulated a big actual material. Historians published monographs, thematic collections, articles, abstracts, reviews, reports, bibliographic pointers, encyclopedic and reference publications, candidate and doctoral dissertations are defended in the Councils on various issues of this area. Domestic historiography of the history of merchants and entrepreneurship Siberia is represented by a significant number of works of historians of the region. The purpose of the article is to investigate the formation and development of the Barnaul scientific school of the history of pre-revolutionary entrepreneurship as a single process of knowledge production, during which traditions are preserved, new issues are being studied, approaches to solving scientific problems. The author used methods of historical research, with the use of the principle of historicism, which allowed to apply historical and logical, historical system methods. The regional-oriented approach made it possible to most fully explore the peculiarities of the Barnaul Research School. Based on a comprehensive analysis, the importance of a scientific school reflecting the development of Russian science is shown. The article identifies the main milestones and the preliminary results of the work of the Barnaul school are summed up. The conclusions were made that in the study of the history of merchants and entrepreneurship, Barnaul historians have achieved certain success, while working out an extensive historiographic base. The interaction of researchers of different generations allows you to exist a scientific school for a long time. The main traditions of the school are: scientific, scientific and methodical, scientific and pedagogical activities; Values remained at the continuity level “Teacher – Student”. As a result of the study, the paradigm principles of the existence of the Barnaul school studying the history of entrepreneurship of pre-revolutionary Siberia are formulated: humanism as a landmark in the organization of the school; priority topics of the history of entrepreneurship; restability by the scientific community of research results; dialogicality as ensuring dialogue, discussion and complementarity.
Chemical genetic analysis of Alepidea amatymbica, a traditional medicine in Africa
Authors:   , Tabiling Zaccheaus
Published: March 2022

Natural products are a reliable source of drug leads, with plant natural products contributingsome of modern medicine’s most important pharmaceuticals. Africa has a rich source ofmedicinal plants that have not yet been heavily investigated for their therapeutic potential. Onesuch plant is Alepidea amatymbica. The traditional use of A. amatymbica suggests a broadrange of bioactivity that has yet to be fully explored. In this thesis, the mechanism of action ofA. amatymbica extract and semi-purified compounds were explored using chemical genetics.

Using the genetic model Saccharomyces cerevisiae (Baker’s yeast), initial phenotypicscreening of the crude extract and the semi-purified compound B showed that A. amatymbicais a potential substrate of the pleiotropic drug response system. A genome-wide analysis, usingthe haploid deletion collection in the pdr1∆pdr3∆ background, revealed five genes that whendeleted showed significantly reduced growth in the presence of A. amatymbica. These wereDin7, Ura5, Eft2, Glo2 and Get5. The functions of the first four genes are mitochondrialgenome stability, de novo pyrimidine biosynthesis, ribosomal translocation and a functionrelating to glyoxalase system, respectively. The most sensitive gene, Get5, is a member of theguided-entry tail anchored protein (Get) complex involved in tail anchor (TA) proteinbiosynthesis. Upon further investigation, we found the entire Get family, as well as theirinteracting chaperones, to be bioactive in A. amatymbica. Further evaluation of the Getpathway was conducted by overexpressing Get3 in pdr1∆pdr3∆get1∆ and pdr1∆pdr3∆get2∆coincidently with A. amatymbica extract treatment, where we found that Get3 overexpressionconfers sensitivity to A. amatymbica. A proteomic analysis using a GFP library was conductedto investigate the mislocalization of TA protein when the cells were treated with A. amatymbicaextract, whereby changes in localization of ER proteins Erg9 and Cyb5 were detected.

Together, these results identified genes, proteins and pathways involved in buffering theactivity of A. amatymbica extract.
Hiding in plain sight: Designing medical devices for adolescents with type 1 diabetes to match their preferences for conspicuity
Authors:   , Hazelton Madeleine
Published: March 2022

Adolescents with type 1 diabetes use medical devices that attract
attention in public settings. While adolescents have varying experiences
with this attention, current medical devices do not allow them control
over the conspicuousness of self-management. Accordingly, this research
used a participatory design methodology to investigate adolescents’
self-management experiences and preferences regarding conspicuity, and
to develop semantic strategies to inform the design of medical
devices. Adolescent participants had varied experiences using their medical
devices to manage type 1 diabetes in public. Some adolescents were
comfortable managing their diabetes in public and disclosing their
condition to new people. However, other adolescents preferred to manage
their type 1 diabetes in private and feel embarrassed disclosing their
diabetes. Four semantic strategies were used to design devices that could appeal
to the different preferences of adolescents: to enhance traditional
medical devices to make them more beautiful, to personalise the medical
device for the user, to disguise the medical device as a non-medical
item, and to conceal the medical device from the public. Adolescents
displayed different preferences towards these strategies and associated
design concepts. As adolescents have a range of experiences and preferences, but little
control over the conspicuousness of their medical devices, the study
found that these medical devices could be better designed to facilitate
adolescents’ agency through catering to their nuanced and differing
preferences for conspicuity.
Correlation between maternal and fetal umbilical cord blood lead concentrations in Libya
Authors: Alemam Hafsa , Enattah Nabil , Fellah Abdulmunam , Elftisi Ehabeddin , Akarem Abdurrahman , Bashein Abdulla
Published: March 2022

Background: People are exposed to lead from car exhaust fumes (leaded petrol), lead-based paints, plumbing systems, cigarette smoking, contaminated soil and dust, foods grown in polluted areas, and water sources. Among the vulnerable subpopulations are pregnant women, fetuses and infants. Aims: To estimate and correlate maternal and neonatal blood lead levels and compare these between neonates and their mothers in Tripoli and Ghadames. Methods: In this cross-sectional study, blood was collected from 120 and 116 mothers and their neonates from Tripoli and Ghadames, respectively. Lead levels were determined using atomic absorption spectrophotometry. A simple questionnaire was filled by the participants using face-to-face interview. Data were analysed using SPSS version 20.0 and Excel. Results: Mean blood and umbilical cord lead levels were 6.83 (standard deviation 4.96) and 6.05 (4.89) µg/dl in mothers and neonates from Tripoli, respectively, and 5.91 (4.02) and 4.54 (4.09) µg/dl from Ghadames. There was no significant difference in blood lead level between mothers from Tripoli and Ghadames. However, there was a significant correlation between maternal blood and umbilical cord blood in Tripoli and Ghadames. Linear regression revealed that neonatal umbilical cord blood lead levels reflected the levels in maternal blood. Blood lead in this study was higher than that reported in industrialized western countries. Conclusion: We detected moderate blood lead levels among pregnant women in Tripoli and Ghadames. It is important to detect the source of lead in the Libyan population to treat this problem effectively.
Analisis Aspek Mekanis Kegagalan Proses Hot Rolling pada Pembuatan Pelat Kuningan Hasil Coran
Authors: Ambardi Pradoto
Published: March 2022

Retak pada pelat kuningan yang mengalami proses pengerolan panas satu tahap dari tebal 13 mm menjadi 7 mm terjadi diseluruh permukaan dengan arah tegak lurus arah pengerolan. Hal ini menyebabkan keinginan untuk mendapatkan tebal akhir pelat 3,10,05 mm tidak dapat dipenuhi. Hasil analisis mekanik menunjukkan bahwa laju regangan (â‚¬) yang diberikan pada saat pengerolan satu tahap menghasilkan nilai yang lebih besar dari pada sensitivitas laju regangan (m).Kondisi tersebut memberikan indikasi bahwa reduksi yang dilakukan dalam satu tahap pengerolan terlalu besar sehingga material tidak mampu menahan deformasi tersebut yang pada akhirnya menghasilkan retak diseluruh permukaan pelat.
Thermal performance assessment of an energy lining for the Lyon-Turin base tunnel
Authors: Alvi Maria Romana , Insana Alessandra , Barla Marco
Published: March 2022

The use of geothermal energy for heating and cooling purposes is an environmentally-friendly and cost-effective alternative with the potential to replace fossil fuels and help to mitigate global warming as well. The paper illustrates the geothermal potential evaluation of a portion of the Lyon-Turin base tunnel considering the thermal activation of the tunnel concrete segmental lining. The international infrastructure will connect Italy to France, crossing the Alps and meeting uncommon climate conditions, reaching a peak temperature of 47 °C, due to its significant rock overburden (up to 2500 m) under the Ambin massif. A thermo-hydraulic numerical model was used to simulate the heat exchange of the system and quantify the power achievable by thermally activating a 10 km-long section of the base tunnel. Sensitivity analyses were performed to investigate the influence of the heat carrier fluid and the air flow velocities as well as the inlet temperature on the heat exchange. Moreover, four different operational conditions were compared to allow for assessing the overall thermal performance of the energy lining in terms of heat exploited and of the capacity of cooling the tunnel.
NEW APPROACHER IN THE DEVELOPMENT OF ALZHEIMER’S DISEASE MODIFYING DRUGS
Authors:   Pedro César de Souza
Published: March 2022

Introduction: Alzheimer’s disease is a more common neurodegenerative disease, affecting 25 million people worldwide, or accounting for about 60 to 70% of all dementia cases. There is currently no exact mechanism to explain the pathophysiology of Alzheimer’s disease, however, cascading metabolic amyloid and post-translational review of tau protein are used as major hypotheses. Objective: To demonstrate in the literature new approaches in the development of Alzheimer’s disease modifiers. Methodology: This is a literature review study with a 5-year time frame, developed from the research of scientific articles published in international journals, through online databases such as “PubMed” and “Science Direct”. Results: Alzheimer’s disease-modifying drugs are not yet available, but many patients may, however, develop phase III clinical trials and are intended to modify as pathological stages leading to the disease. As disease-modifying therapies under study, these changes also affect Aβ and tau protein and also cause inflammation and oxidative damage. The results obtained in the clinical trials performed were positive and promising and are still under study. The results show that there is still a long way to go in the development of Alzheimer’s disease modifying drugs. Conclusion: The results demonstrated that there is still a long way to go in the development of Alzheimer’s disease modifying drugs, but nevertheless levels at the research level should be continued in order to improve the pathophysiology of the disease and find an effective treatment for this disease the same.
ROLE OF ART AND MUSIC IN RELIEVING STRESS, DURING AND AFTER COVID-19's LOCKDOWN
Authors: Gupta Sunita
Published: March 2022

Indian art presents in the form of art from the science of the body to the science of every corpus of the mind, from earth to sky, north to south, east to west, and from Kashmir to Kanyakumari as the subject of its stream of thought. Is. Animals, vegetation, sound, mind, mind, intellect, earth, space, sky, constellations, oceans, rivers, mountains, mountains, animals, birds, forests are all contained in Indian paintings. The artist and musician feels the beauty and sound of nature in every particle of the world through emotions and imagination. Trying to see each side from a new perspective, presents it. Art and music are the sumptuous expressions of the artist's feelings and perceptions. The purpose of this expression is to provide joy, to create good feelings in life, to remove social problems and sufferings and to lead human beings on the best and inspired path through rasaic artefacts.

भारतीय कला षरीर के विज्ञान से लेकर मन के प्रत्येक कोष के विज्ञान को, पृथ्वी से लेकर आसमान को, उŸार से दक्षिण दिषा को, पूर्व से पष्चिम दिषा को, तथा कष्मीर से लेकर कन्याकुमारी को अपनी चिंतन धारा का विशय बनाकर कला रूप में प्रस्तुत करती है। प्राणी, वनस्पति, ध्वनि, मन्, चिक्त, बुद्धि, पृथ्वी, अंतरिक्ष, आकाष, नक्षत्र, बह्याण्ड, नदियां, पर्वत, पहाड़ पषु-पक्षी, वन सभी कुछ भारतीय चित्रों में समाहित है। प्रकृति के कण-कण में व्याप्त सौदर्य और नाद की अनुभूति कलाकार और संगीतकार संवेगो और कल्पना से करता है। प्रत्येक पक्ष को नये-नये आयामों से देखने का प्रयास कर प्रस्तुत करता है। कला और संगीत कलाकार के भावों और बोधों की सरस अभिव्यक्ति है। इस अभिव्यक्ति का उद्देष्य आनन्द प्रदान करना, जीवन में षुभ भावों का उदय करना, सामाजिक समस्याओं और कश्टों का निवारण और रसात्मक कलाकृतियों के माध्यम से मानव को श्रेश्ठ और प्रेरित मार्ग पर अग्रसर करना है।
Influence of Whole Body Vibration on Drop Jump Landings and Knee Loading Mechanics
Authors: Hubble Ryan P. , Wang Henry , Nagelkirk Paul , Avedesian Jason M. , Wilkinson Robert , Dickin D. Clark
Published: March 2022

Plyometric training is one commonly used method of improving jump performance through improving explosive power generation. Research has also demonstrated that whole body vibration (WBV) can improve jumping and enhance explosive strength especially when supplementing resistance and plyometric training programs. With the drop jump being a common training skill, proper lower extremity landing mechanics are important to consider. Limited evidence suggests that WBV may reduce ground reaction forces and improve knee stability however, its influence on knee loading have not been reported. This study sought to examine the effects of WBV on ground reaction forces and knee valgus during a drop jump. 19 participants (10 female) completed drop jumps pre, immediately post, 10 & 20 minutes post WBV. Results were analyzed by repeated measures ANOVA. Main findings indicated that valgus knee angle increased significantly (p=0.011) post vibration and remained elevated across the 10 & 20 minute post vibration time intervals. Significant differences between sexes revealed that females demonstrated greater internal knee abduction moments (p=0.038). Findings that WBV increases knee valgus angle, a position linked to anterior cruciate ligament injury, suggest further investigation understand the effects of WBV on neuromuscular control and eccentric loading. Strength and conditioning professionals should exercise caution when incorporating WBV into plyometric protocols.
Belajar dan Bermain dengan Kreatif untuk Meningkatkan Kemampuan Membaca dan Berhitung Anak Di Dusun Berenyok Desa Mujur Kecamatan Praya Timur
Authors: Riani Olivia  , Miftahul Wasli  , Nirmala Sari  , Dadi Setiadi
Published: March 2022

Tingkat  kemampuan membaca dan berhitung pada siswa di Dusun Berenyok Desa Mujur Lombok Tengah masih terbilang rendah, hal ini dilihat dari hasil pembelajaran yang telah dilakukan selama kegiatan KKN Terpadu berlangsung. Tujuan dari pengadaan kegiatan belajar - mengajar selain membantu orang tua siswa juga untuk  memotivasi  para  peserta  didik  untuk  lebih giat belajar dan  mengerjakan tugas-tugas dari sekolah dengan semangat. Metode yang digunakan yaitu pendampingan siswa melalui kegiatan bimbingan belajar dan bermain yang dilaksanakan di masjid yang bertempat di Dusun Berenyok Desa Mujur Kecamatan Praya Timur Kabupaten Lombok Tengah. Pelaksanaan kegiatan ini dilakukan dua kali seminggu yaitu hari Rabu dan Kamis selama tujuh minggu pada bulan November sampai bulan Januari 2021, pada pukul 16.00 WITA hingga 17.30 WITA. Teknik pengumpulan data secara tes untuk mengetahui perkembangan prestasi belajar siswa, dan secara non tes dengan wawancara untuk mengetahui motivasi belajar siswa. Hasil menunjukkan pembelajaran dengan menggunakan konsep bermain sangat efektif dalam meningkatkan kemampuan membaca anak dan dapat meningkatkan kemampuan berhitung permulaan pada anak.
Optimalisasi Pemanfaatan Limbah Plastik dan Limbah Rumah Tangga Dalam Upaya Penerapan Zero Waste di Desa Pengadang
Authors: Nisa Rahmadania Erlan  , Sukmadi Farid Sabri  , Rizandi Mahendra  , Eliza Mawarti  , Sania  , Nina Tunmi  , Nur Amalia  , Tazkiya Aulia Rachman  , M. Dhava Estiwan  , Hasanul Falah Putra Junaidy  , DioYudha Prawira Bakary  , Nuriadi
Published: March 2022

Kuliah kerja nyata (KKN) merupakan salah satu bentuk wujud implementasi dari Tri Dharma perguruan tinggi yaitu kewajiban perguruan tinggi untuk melaksanakan pendidikan, pengajar, penelitian serta pengabdian kepada masyarakat. Mahasiswa mempunyai peran strategis sebagai agent of change (agen perubahan). KKN merupakan mata kuliah wajib yang harus ditempuh diperguruan tinggi Universitas Mataram yang memiliki tujuan yaitu melalui keterlibatan mahasiswa di dalam mengindentifikasi, merumuskan serta memecahkan masalah yang ada dalam masyarakat. Salah satu masalah dalam masyarakat yaitu sampah maka diambil tema tentang Zero Waste. Zero Waste merupakan suatu upaya konservasi sumber daya yang melibatkan produksi, konsumsi, penggunaan kembali, dan pemulihan produk hingga kemasannya, zerowaste juga, merupakan filsafat yang mendorong daur ulang sumber daya, dari system linier menuju siklus tertutup, sehingga semua produk digunakan Kembali. Kelompok Mahasiswa KKN UNRAM memiliki misi untuk menjadikan Masyarakat Desa Pengadang Kecamatan Praya Tengah Kabupaten Lombok Tengah menerapkan upaya bebas sampah diharapkan dapat mengeliminasi sampah yang dapat menjadi ancaman bagi kesehatan manusia, alam, hewan, maupun bumi kita ini melalui program kerja terkait Zero Waste.Beberapa kegiatan yang dilakukan yaitu sosialisasi pembuatan eco enzyme dari sampah dapur, sosialisasi tentang zero waste, biopori, penanaman bibit pohon dan pembuatan ecobrick dari sampah-sampah plastik. Hasilnya diharapkan masyarakat lebih peduli dengan kebersihan lingkungan sekitar dengan tidak membuang sampah sembarangan dan bisa memanfaatkan sampah yang tidak bernilai menjadi bernilai jual tinggi sehingga lingkungan masyarakat bisa terhindar dari sampah dan perekonomian masyarakat setempat lebih baik.
Maternal and fetal outcome of placenta previa.
Authors: Uzma Manzoor  , Nadia Sharif  , Uzma Shehzad  , Saadia Bano  , Iram Aslam  , Sadaqat Ali
Published: March 2022

Objectives: To determine the maternal and fetal outcome in patients presented with major degree Placenta previa and to evaluate the Potential risk factors. Study Design: Descriptive Case Series study. Setting: Department of Obstetrics and Gynecology Independent University Hospital Faisalabad. Period: January 2020 to February 2021. Material & Methods: All patients with major degree previa confirmed by ultrasonography beyond 28 weeks of gestation were selected irrespective of their parity, type of placenta previa and with live or dead fetus. Results: Total 38 patients were selected with Major degree placenta previa in 1 year of duration. 47% patients were in age group 31-35 years and 65.7% patients were grand multi-para. In our study 73.6% patients were having previous scar uterus. All patients received blood transfusions and cesarean hysterectomy in 36.8% of patient’s done due to placenta previa and uncontrolled hemorrhage. Only 2 patients got bladder injuries during surgery and in one patient required hysterectomy has to be done later. Regarding neonatal outcome 47.3% neonates were active and required no resuscitation and 21% neonates expired within 48 hours. Conclusions: Now a day’s major degree placenta previa is a main obstetrical challenge associated with blood transfusion, ICU admissions and Obstetrical hysterectomy. Fetal outcome was relatively satisfactory. Maternal complications can be reduced by early diagnosis, Identification of the risk factors, correction of Anemia, Blood arrangement & Team work in Territory care hospital.
Frequency of medical comorbidities in patients attending ORM & Maxillofacial Surgery Department at University College of Dentitistry, University of Lahore.
Authors: Ahmad Liaquat  , Rabia Naseer  , Tahmasub Faraz Tayyab  , Muhammad Rashid  , Komal Qudsia Sattar  , Javeria Usman
Published: March 2022

Objectives: To find the frequency and type of comorbid conditions in patients presenting with oral diseases. Study Design: Observational study. Setting: Department of Oral and Maxillofacial Surgery, University College of Dentistry, University of Lahore. Period: January 2018 to December 2019. Material & Methods: After approval from the ethical committee, all cases presenting with oral diseases to the oral and maxillofacial surgery department were recruited consecutively. A thorough history and relevant examinations were made. All the previous records of the patient, including laboratory tests and the medical summary, were reviewed for the existence of any comorbid conditions. The data was entered on the spreadsheet. Descriptive statistics were used. Frequencies and percentages were calculated for comorbid conditions. Results: This study included 17155 patients who visited the oral and maxillofacial surgery department for procedures related to oral surgery. Others patients presenting to other departments of dentistry were excluded. Out of these, 4056 patients (24%) had comorbid conditions. Among these patients, 77% had single comorbid condition and 23% had multiple systemic disease. The most common comorbid condition was hypertension (77%), followed by diabetes (33%) and hepatitis (11%). Conclusion: A high prevalence of comorbidities was found in our study. Hypertension, diabetes mellitus, and hepatitis C were the common comorbidities. In addition, a significant number of patients had multiple comorbidities.
Aproximación a las terapias de remplazo renal continuas.
Authors: Carlos Martínez Villar  , Luisa Maria Charco Roca  , Laura Rodriguez Ruiperez  , Pedro Manuel Canales Lara
Published: March 2022

La insuficiencia renal aguda (IRA) se define como una disminución abrupta de la función renal y constituye una entidad muy frecuente en las unidades de cuidados intensivos (UCI). Su etiología es multifactorial y se estima que en torno a un 5-10% de los pacientes que desarrollan IRA en las UCI van a requerir de una terapia de remplazo renal. El objetivo de esta revisión bibliográfica es hacer una aproximación a los conocimientos que debe poseer un anestesiólogo sobre el manejo de las terapias de remplazo renal. Para la elaboración de esta revisión se ha realizado una búsqueda bibliográfica no sistemática en las bases de datos Pubmed y Cochrane y se incluyen meta-análisis, revisiones y guías de práctica clínica publicados en los últimos 10 años.
Consideraciones perioperatorias del síndrome de Noonan en el adulto.
Authors: Ana Martinez Saniger  , Rosana Guerrero Dominguez  , Rafael Rubio Romero  , Ignacio Jiménez López
Published: March 2022

El síndrome de Noonan (SN) es una enfermedad monogénica con patrón de herencia autosómico dominante con una incidencia de uno de 1:1500-2500. Este síndrome es de particular interés para el anestesiólogo por ser considerado probable vía aérea difícil, presentar talla baja, dismorfia facial, alteraciones en la hemostasia, musculoesqueléticas y cardiológicas, entre otras, cuya evolución condicionan la esperanza de vida alcanzando edades más avanzadas en la actualidad gracias al control de las mismas . Por consiguiente requieren intervenciones en la edad adulta donde no hay tantos casos reportados como en la infancia . Presentamos un caso de un paciente de 53 años con SN programado para resección de neurinoma cervical durante el cual destacó un sangrado aumentado durante la cirugía no esperado. Nuestro objetivo es establecer un plan anestésico específico tras exponer las características de la enfermedad para minimizar las complicaciones perioperatorias.
Bases de la interacción corazón-pulmón en Anestesiología y Cuidados Intensivos.
Authors: Daniel Paz Martín  , María Serna Gandía  , María Sherezade Tovar Doncel  , Fernando García-Montoto Pérez
Published: March 2022

La interacción entre el corazón y los pulmones es uno de los ritmos básicos de la vida y fluctúa con la frecuencia del latido cardiaco y de la respiración. El conocimiento de este conjunto de interacciones mecánicas, neuronales y humorales resulta fundamental en la práctica de la Anestesiología y los Cuidados Intensivos. Por una parte, son la base de la monitorización hemodinámica funcional y ayudan a entender sus limitaciones, por otra, permiten profundizar en la comprensión de la fisiología del paciente críticamente enfermo y, muy especialmente, en los efectos de la ventilación mecánica en sujetos con reserva cardiovascular comprometida.
Pembelajaran Daring dalam Meningkatkan Kemandirian Belajar Peserta Didik Kelas 3 Sekolah Dasar
Authors: Putra Anggoro Dwi , Bramasta Dhi
Published: March 2022

Penelitian ini bertujuan untuk mengetahui analisis pembelajaran daring dalam meningkatkan kemandirian belajar peserta didik kelas III SD Negeri 8 Kranji Purwokerto Timur. Penelitian ini menggunakan metode deskriptif kualitatif. Subjek dalam penelitian ini adalah guru kelas III, orang tua siswa dan peserta didik kelas III SD Negeri 8 Kranji Purwokerto Timur. Teknik dan instrumen pengumpulan data penelitian ini dengan observasi, wawancara, dan dokumentasi. Uji keabsahan data menggunakan triangulasi sumber dan teknik. Hasil penelitian menunjukkan bahwa pembelajaran daring dalam penyampaian materi pembelajaran menjadi lebih rapi, sistematis, terstruktur dan meningkatkan kemandirian serta tanggungjawab peserta didik. Kendala pembelajaran daring yaitu tidak semua siswa memiliki antusias, serta tidak semua siswa bisa mengikuti pembelajaran karena siswa belum mempunyai gadget sendiri.
Penanaman Nilai-Nilai Islam dalam Konstruksi Kemuliaan Intan oleh Pedagang Intan untuk Memelihara Stabilitas Pasar Intan di Martapura Kalimantan Selatan
Authors: Hidayat Yusuf
Published: March 2022

The glory of diamond as eternal and scarce thing and the symbol of love is a construction made by diamond merchants to stabilize diamond market. For diamond merchants in Martapura, the construction of diamond glory enables them to constantly behave nobly in the process of diamond trade to attain success in diamond trade and perform Islamic values as Muslim merchants. This paper attempts to investigate Islamic values applied as the basis of diamond trade practice and figure out the roles of values implementation in the stability of dynamic diamond market. It is field study making use of qualitative method to obtain depth understanding of social reality. This study took place in Martapura known as diamond city where diamond merchants interact and fifteen of them were interviewed as informants consisting of three big merchants, four middle-scale merchants, four small-scale merchants and four ‘pengempet”. The study revealed that the diamond merchants believe that in order to succeed trading diamond, they need to nobly behave as the form of implementation of diamond construction as noble commodity. As Muslim merchants, they develop values in diamond trade derived from Islam teachings: honesty, no debt, togetherness and the use of respect “hajj”. These values can create the stability in diamond trade.
Cesare, Pompeo, l’elefante e la fortuna
Il volere umano tra natura, società e colpi della sorte nei libri 7-8 della Storia Naturale di Plinio il Vecchio
Authors: Cattanei Elisabetta
Published: March 2022

To obtain a complete description of the paradeigmata voluntatis, it is necessary to question natural science as well as philosophical and literary documents. Therefore, it becomes interesting to face Pliny the Elder, a contemporary of Seneca. Pliny’s attention is turned to man placed in a world where the will of destiny plays an explicit role, in a completely unpredictable game of alternation between positive and negative. A method of investigation is emerging that does not disdain to engage between science and myth, between empirical reality and dreams, between limits and protagonists seeking their overcoming, as in the case of Caesar and Pompey.
Agostino. Volere e potere
Authors: Pagani Paolo
Published: March 2022

This contribution reconstructs – with the necessary references to the Manichaean and Pelagian positions – the relationship between will and power in the Augustine’s thought. It focuses on the Book VIII of Confessions, extending to the previous (especially De duabus animabus, De libero arbitrio III) and following (especially De natura et Gratia, De Civitate Dei V and XIV, De Gratia et libero arbitrio) texts, in which the themes of this Book are developed. According to Augustine, the human will, when it is not gathered in itself, is not performing; but even when it is performing, it is unable to carry out what it proposes. This double impotence introduces the theme of original sin and opens up a perspective on the theme of velleitas.
Productive and interior indicators in pigs when microcapsulatedlactobifadol is included in the diet
Authors: Sein O.B. , Chernikov D.P.
Published: March 2022

The results of studies of the effect of the microcapsulated probiotic lactobifadol on productive and interior indicators in pigs are presented. It is shown that the microcapsulated preparation obtained by the original technology has a pronounced stimulating effect on metabolism. After its application, pigs had higher average daily body weight gains (583,0±8.8-600,0±9,5 g) compared with animals receiving non-encapsulated lactobifadol (507,0±10,1-533,0±11,0 g) and control (463,0±9,2-483,0±8,5 g). The blood contained significantly (p<0.05) more red blood cells and hemoglobin. At the same time, the content of leukocytes was within the physiological boundaries. The encapsulated lactobifadol had a positive effect on the biochemical status. Pigs receiving the drug on the 30th day of the experiment had significantly more (p<0,05-0,01) total protein (75,7±2,3 g/l), total calcium (3,10±0,19 mmol/L), glucose (3,42±0,10 mmol/L), vitamins A (0,55±0,04 mg/l) and C (3,93 ± 0,18 mmol/l) compared with control group animals (6,83±2,0 g/l; 2,60±0,15 mmol/l; 2,72±0,15 mmol/l; 0,28±mg/l; 2,9±0,17 mmol/l). At the same time, the content of inorganic phosphorus (1.65±0.18 mmol/l) and total lipids (4,48±0,21 g/l) was at a lower level than in animals not receiving probiotic preparation (1,85±0,16 mmol/l; 4,67±0,18 g/l). The developed microcapsulate-dlactobifadol is recommended for use in pig breeding practice.
Influence of putrefactive decay of the hoof horn in sheep on its biochemical and biomechanical properties and hemodynamics in sick animals
Authors: Tolkachev V.A. , Vanina N.V. , Kolomiytsev S.M. , Suvorova V.N. , Kazakova D.L.
Published: March 2022

Sheep breeding is currently an intensively developing branch of animal husbandry. However, one of the limiting factors of its further economically viable development is the mass distribution in the conditions of large sheep-breeding farms with a non-walking technology for keeping purulent-necrotic and putrefactive lesions in the tissues of the distal part of the limbs. The etiology and pathogenesis of these pathologies is currently not fully scientifically substantiated and detailed. In this regard, we assessed the effect of putrefactive decay of the hoof horn in sheep on its biochemical and biomechanical properties, as well as on hemodynamics in diseased animals in comparison with clinically healthy ones. According to the results of the studies, it was determined that during the putrefactive decay of the hoof horn, the percentage of moisture was higher by 12.37%, and the inorganic residue (ash), fat, protein and sulfur was lower by 73.84%, 36.84%, 5.92 % and 3.82% than in its normal morpho-functional state, respectively. This, in turn, had an impact on the biomechanical properties of the hoof horn, namely, during its putrefactive decay, a decrease in compressive elasticity by 3.82%, tensile strength by 28.76%, resistance to repeated bending by 9.61% was recorded relative to similar biomechanical indicators in samples of the hoof horn obtained from clinically healthy sheep. At the same time, in the hemodynamics of diseased animals with putrefactive decay of the hoof cover, in a comparative aspect with similar hematological indicators in clinically healthy sheep, a decrease in the number of erythrocytes and platelets by 28.94% and 7.03%, a decrease in hemoglobin concentration and hematocrit value by 22.88 % and 8.80%, an increase in the number of leukocytes and erythrocyte sedimentation rate by 89.14% and 44.70%, respectively.
Therapeutic efficacy of various methods for the treatment of thermal burns in animals (clinical and experimental study)
Authors: Everstova E.A. , Shuklin S.I. , Tolkachev V.A. , Pereverzev A.N.
Published: March 2022

The purpose of the work was to test and compare the therapeutic efficacy of the wound healing spray "Acerbin" for medical purposes and Vishnevsky's balsamic liniment in the treatment of thermal burns. The work was carried out on laboratory white mice in the amount of 60 individuals, in which thermal burns of the skin on the dorsal surface of the croup were modeled, and then the tested drugs were applied to the burn site in two experimental groups. Evaluation of therapeutic efficacy in terms of the dynamics of reduction in the area of burn injury, the index of its epithelialization and in terms of normalization of the cytomorphological composition of whole blood. The conducted studies made it possible to establish that the applications of the drug "Acerbin" contributed to a more intensive dynamics of healing of burn defects than the use of Vishnevsky's balsamic liniment, namely, on the 3rd day, the area of burns was less by 0,32%, on the 5th day - by 25,21%, on the 7th day - by 14,57%, on the 10th day - by 18,92%, on the 14th day - by 19.5%. The index of epithelialization of burns under the influence of applications of the drug "Acerbin" was higher than with applications of Vishnevsky liniment on the 5th day by 0,14%, on the 7th day - by 0,10%, on the 10th day - by 0, 10%, on the 14th day - by 0,10%. In the cytomorphological composition of the blood, applications of the drug "Acerbin" caused a more intense increase in the number of platelets than similar manipulations of Vishnevsky's liniment, namely, on the 3rd day, there were more platelets by 2,84%, on the 5th day - by 6,40%, on the 7th day. on the first day - by 5,62%, on the 10th day - by 8,16%, on the 14th day - by 14,29%, respectively. Applications of the drug "Acerbin" more effectively stopped post-burn leukocytosis than Vishnevsky's balm, that is, on the 3rd day there were less leukocytes by 35,60%, on the 5th day - by 41,34%, on the 7th day - by 24,61%, on the 10th day - by 16,73%, on the 14th day - by 11,39%, respectively. Thus, the data obtained on the therapeutic efficacy of the wound healing spray "Acerbin" in the treatment of thermal burns in animals allow us to recommend it for use in practical veterinary medicine for the treatment of combustial pathology.
Identification of limiting resources in the diets of cows to hypomicroelementoses prevention
Authors: Dronov V.V. , Kulachenko V.P. , Oliva T.V. , Dronova L.A. , Lebedevа N.V.
Published: March 2022

The analysis of feed for lactating cows in 19 farms of eight districts of the Belgorod region was carried out from 1985 to 2021. Examined: green feed, roughage of natural and artificial drying, succulent feed (including canned feed), grain and its processed products, food industry waste, feed of animals and bacteriogenic. The minerals in feed were examined in the testing laboratory of the Belgorod State Agrarian University according to state standards. Reference analysis of the minerals in the feed for cows in the farms of the Belgorod region with the data of the "Federal research center for animal husbandry standards" has been carried out. Investigations of diet for lactating cows, taking into account the data presented in the "Recommendations on the chemical composition and nutritional value of feeds used to compose rations for farm animals in the Belgorod region", We found that rations are deficient in phosphorus by 40.9%, copper - by 32.6%, zinc - by 42.8%, cobalt - by 26.8%, iodine - by 32.9% and superfluity of iron. Calcium was over the limit by 31.0%, manganese - by 22.9%. Forage harvested on the farms of the Belgorod Region, a biogeochemical province with a low content of copper, zinc, sulfur and iodine in soils, cannot be considered complete in terms of mineral composition. To lactating cows hypomicroelementoses prevention necessary to set a correction factor when calculating the balance of rations and be sure to use feed mineral supplements, including limited minerals in quantities necessary not only to ensure the normal vital activity of cows, but also to obtain genetically inherent milk productivity from them.
Known and unknown aspects of the use of propylene glycol and glycerin and possible solutions
Authors: Yevglevskaya E.P. , Yevglevsky A.A.
Published: March 2022

Traditionally, the main focus of the use of all known energy products (energy additives) in modern dairy farming is designed for one or another energy-rich glucoplastic component. It is quite obvious that with this, animal breeders are trying to fill the energy needs of the cows' body during stressful periods when they reach a high level of dairy productivity. No matter how energy-rich the feed energy additives are, they are all aimed at achieving maximum productivity, while health issues remain in the background. For example, the extensive experience of using propylene glycol and glycerin as feed energy products for cows did not reduce the problem of fatty hepatosis in any way. However, how to solve the problem of energy deficiency, including reduced risk of side effects of feed propylene glycol and glycerin? What is the innovation of the approach? The thing is that the main emphasis is not at all on the glucoplastic component, no matter how "rich" it is with energy, but on the activation of energy metabolism, in particular the activation of the most productive aerobic pathway of energy synthesis. And here's why. In terms of the efficiency of energy synthesis, the aerobic pathway surpasses the anaerobic pathway by 19 times. Glucose synthesis during lipolysis is much more difficult and much longer. Before turning into an energy substrate (glucose), glycerin is synthesized from fats. If the lipolysis process takes place under conditions of insufficient oxygen supply, then this is accompanied by the formation of a large number of acidic by-products-ketoacids. With a large accumulation, they become poisonous to the body. Thus, in conditions of insufficient oxygen supply of cells with oxygen, energy metabolism follows the least productive path with the formation of an excess of lactate and keto acids problematic for the body. It is this vital aspect that has been taken into account and technically implemented using the example of feed propylene glycol and glycerin. The basis of the innovative approach is the activation of energy exchange. Succinates are used as activators of energy metabolism. Cyanocobalamin is used as an activator of digestive processes and hematopoiesis. Everything is technologically simple, economically affordable, environmentally safe and absolutely harmless to the body of animals. In terms of production, this approach is an alternative to the commercial interest of manufacturers and suppliers of energy feed additives interested in the constant (daily) introduction of "energy-rich" glucoplastic agents into the diet. Moreover, the use of such energy feed additives, for example, as fat-like energy products, is very dangerous for animal health. How to make them safe is shown in this paper.