bluuebunny/crossref_metadata_2025 huggingface dataset:
Gamification Assisted Language Learning for Japanese Language Using Expert Point Cloud Recognizer
Authors: Udjaja Yogi
Published: December 2018

Starting from people limitations to understand Japanese, education and social life of those people in Japan can be hindered. Therefore, a game is needed that allows one to understand Japanese using Gamification Assisted Language Learning (GALL) method, involving the introduction of Japanese language implementation using expert point cloud ($EP) recognizer. This method is used to stimulate the sensory and motor nervous system and motivate students (players) to study harder. This can be evidenced by increase in players ability from 20% to 100%.
Cis-Acting circ-CTNNB1 Promotes β-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1
Authors: Yang Feng , Fang Erhu , Mei Hong , Chen Yajun , Li Huanhuan , Li Dan , Song Huajie , Wang Jianqun , Hong Mei , Xiao Wenjing , Wang Xiaojing , Huang Kai , Zheng Liduan , Tong Qiangsong
Published: December 2018

Circular RNAs (circRNA), a subclass of noncoding RNA characterized by covalently closed continuous loops, play emerging roles in tumorigenesis and aggressiveness. However, the functions and underlying mechanisms of circRNA in regulating Wnt/β-catenin signaling and cancer progression remain elusive. Here, we screen cis-acting circRNA generated by β-catenin (CTNNB1)/transcription factor 7–like 2 genes and identify one intronic circRNA derived from CTNNB1 (circ-CTNNB1) as a novel driver of cancer progression. Circ-CTNNB1 was predominantly expressed in the nucleus, upregulated in cancer tissues and cell lines, and associated with unfavorable outcomes in patients with cancer. Circ-CTNNB1 promoted β-catenin activation, growth, invasion, and metastasis in cancer cells. Circ-CTNNB1 bound DEAD-box polypeptide 3 (DDX3) to facilitate its physical interaction with transcription factor Yin Yang 1 (YY1), resulting in the transactivation of YY1 and transcriptional alteration of downstream genes associated with β-catenin activation and cancer progression. Preclinically, administration of lentivirus-mediated short hairpin RNA targeting circ-CTNNB1 or a cell-penetrating inhibitory peptide blocking the circ-CTNNB1–DDX3 interaction inhibited downstream gene expression, tumorigenesis, and aggressiveness in cancer cells. Taken together, these results demonstrate cis-acting circ-CTNNB1 as a mediator of β-catenin signaling and cancer progression through DDX3-mediated transactivation of YY1.

Significance:

These findings reveal the oncogenic functions of a cis-acting circular RNA in β-catenin activation and cancer progression, with potential value as a therapeutic target for human cancers.
Inhibition of Notch Signaling Enhances Chemosensitivity in B-cell Precursor Acute Lymphoblastic Leukemia
Authors: Takam Kamga Paul , Dal Collo Giada , Midolo Martina , Adamo Annalisa , Delfino Pietro , Mercuri Angela , Cesaro Simone , Mimiola Elda , Bonifacio Massimiliano , Andreini Angelo , Chilosi Marco , Krampera Mauro
Published: December 2018

Notch3 and Notch4 support survival of primary B-cell acute lymphoblastic leukemia (B-ALL) cells, suggesting a role for Notch signaling in drug response. Here we used in vitro, in silico, and in vivo mouse xenograft model-based approaches to define the role of the Notch pathway in B-ALL chemosensitivity. We observed significant Notch receptor and ligand expression in B-ALL primary cells and cell lines. Primary leukemia cells from high-risk patients overexpressed Notch3, Notch4, and Jagged2 while displaying a reduction in expression levels of Notch1-4 following chemotherapy. We then analyzed in vitro cell survival of B-ALL cells treated with conventional chemotherapeutic agents alone or in combination with Notch signaling inhibitors. Gamma-secretase inhibitors (GSI) and anti-Notch4 were all capable of potentiating drug-induced cell death in B-ALL cells by upregulating intracellular levels of reactive oxygen species, which in turn modulated mTOR, NF-κB, and ERK expression. In NOG-mouse-based xenograft models of B-ALL, co-administration of the Notch inhibitor GSI-XII with the chemotherapeutic agent Ara-C lowered bone marrow leukemic burden compared with DMSO or Ara-C alone, thus prolonging mouse survival. Overall, our results support the potential effectiveness of Notch inhibitors in patients with B-ALL.

Significance: Inhibition of Notch signaling enhances the chemosensitivity of B-ALL cells, suggesting Notch inhibition as a potential therapeutic strategy to improve the outcome of patients with B-ALL.
Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
Authors: Blagden Sarah P. , Hamilton Anne L. , Mileshkin Linda , Wong Shirley , Michael Agnieszka , Hall Marcia , Goh Jeffrey C. , Lisyanskaya Alla S. , DeSilvio Michelle , Frangou Eleni , Stronach Euan A. , Gopalakrishna Prashanth , Meniawy Tarek M. , Gabra Hani
Published: December 2018

Purpose:

Preclinically, AKT kinase inhibition restores drug sensitivity in platinum-resistant tumors. Here the pan-AKT kinase inhibitor afuresertib was given in combination with paclitaxel and carboplatin (PC) in patients with recurrent platinum-resistant epithelial ovarian cancer (PROC) and primary platinum-refractory ovarian cancer (PPROC).

Patients and Methods:

Part I was a combination 3+3 dose escalation study for recurrent ovarian cancer. Patients received daily continuous oral afuresertib at 50–150 mg/day with intravenous paclitaxel (175 mg/m2) and carboplatin (AUC5) every 3 weeks for six cycles followed by maintenance afuresertib at 125 mg/day until progression or toxicity. Part II was a single-arm evaluation of the clinical activity of this combination in recurrent PROC (Cohort A) or PPROC (Cohort B). Patients received oral afuresertib at the MTD defined in Part I in combination with PC for six cycles, followed by maintenance afuresertib. Primary endpoints were safety and tolerability of afuresertib in combination with PC (Part I, dose escalation), and investigator-assessed overall response rate (ORR) as per RECIST version 1.1 (Part II).

Results:

Twenty-nine patients enrolled into Part I, and 30 into Part II. Three dose-limiting toxicities of grade 3 rash were observed, one at 125 mg and two at 150 mg afuresertib. The MTD of afuresertib in combination with PC was therefore identified as 125 mg/day. The most common (≥50%) drug-related adverse events observed in Part I of the study were nausea, diarrhea, vomiting, alopecia, fatigue, and neutropenia and, in Part II, were diarrhea, fatigue, nausea, and alopecia. The Part II ORR in the intention to treat patients was 32% [95% confidence interval (CI), 15.9–52.4] by RECIST 1.1 and 52% (95% CI, 31.3–72.2) by GCIG CA125 criteria. Median progression-free survival was 7.1 months (95% CI, 6.3–9.0 months).

Conclusions:

Afuresertib plus PC demonstrated efficacy in recurrent PROC with the MTD of afuresertib defined as 125 mg/day.
Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview
Authors: Wang Li-Hui , Wu Chun-Fu , Rajasekaran Nirmal , Shin Young Kee 
Published: December 2018

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research has been conducted over the last few decades to elucidate the role of TSGs in cancer development. In cancer, loss of TSG function occurs via the deletion or inactivation of two alleles, according to Knudson’s two-hit model hypothesis. It has become clear that mutations in TSGs are recessive at the level of an individual cell; therefore, a single mutation in a TSG is not sufficient to cause carcinogenesis. However, many studies have identified candidate TSGs that do not conform with this standard definition, including genes inactivated by epigenetic silencing rather than by deletion. In addition, proteasomal degradation by ubiquitination, abnormal cellular localization, and transcriptional regulation are also involved in the inactivation of TSGs. This review incorporates these novel additional mechanisms of TSG inactivation into the existing two-hit model and proposes a revised multiple-hit model that will enable the identification of novel TSGs that can be used as prognostic and predictive biomarkers of cancer.
FOXD1 Promotes Cell Growth and Metastasis by Activation of Vimentin in NSCLC
Authors: Li Dan , Fan Suyun , Yu Fei , Zhu Xuchao , Song Yingchun , Ye Meng , Fan Lihong  , Lv Zhongwei
Published: December 2018

Background/Aims: Forkhead box D1 (FOXD1) has a well-established role in early embryonic development and organogenesis and functions as an oncogene in several cancers. However, the clinical significance and biological roles of FOXD1 in non-small cell lung cancer (NSCLC) remain largely unknown. Methods: A total of 264 primary NSCLC tissue samples were collected. The expression levels of FOXD1 in these samples were examined by immunohistochemical staining. The expression of FOXD1 was knocked down by lentiviral shRNA. The relative expression of FOXD1 was determined by qRT-PCR, Western blotting and immunofluorescence image. The functional roles of FOXD1 in NSCLC were demonstrated cell viability CCK-8 assay, colony formation, cell invasion and migration assays, and cell apoptosis assay in vitro. In vivo mouse xenograft and metastasis models were used to assess tumorigenicity and metastatic ability. The Chi-square test was used to assess the correlation between FOXD1 expression and the clinicopathological characteristics. Survival curves were estimated by Kaplan-Meier method and compared using the log-rank test. The Cox proportional hazards model was used for univariate and multivariate analyses. Results: We determined that higher levels of FOXD1 were present in NSCLC tissues, especially in metastatic NSCLC tissues. FOXD1 was also higher in all NSCLC cells compared with normal human bronchial epithelial cells. A higher expression level of FOXD1 was associated with malignant behavior and poor prognosis in NSCLC patients. Knockdown of FOXD1 significantly inhibited proliferation, migration, and invasion in vitro and tumor growth and metastasis in vivo, and it increased the apoptosis rates of NSCLC cells. Mechanistic analyses revealed that FOXD1 expressed its oncogenic characteristics through activating Vimentin in NSCLC. Multivariate Cox regression analysis indicated that FOXD1 was an independent prognostic factor both for overall survival (OS) and disease-free survival (DFS) in NSCLC patients. Conclusion: Our results indicated that FOXD1 might be involved in the development and progression of NSCLC as an oncogene, and thereby might be a potential therapeutic target for NSCLC patients.
Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-κB and MAPK Signaling Pathways
Authors: Chen Xiao , Li Xiaoqun , Zhai Xiao , Zhi Xin , Cao Liehu , Qin Longjuan , Su Jiacan
Published: December 2018

Background/Aims: Bone homeostasis is associated with the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Unbalanced bone homeostasis as a result of reduced osteogenesis or excessive osteoclastogenesis can lead to disorders such as osteoporosis, Paget’s disease, and rheumatoid arthritis. Shikimic acid is a cyclohexanecarboxylic acid, reported to exhibit pharmacological properties including anti-inflammatory and antioxidant activities. However, its effects on bone homeostasis remain unknown. Methods: First, the in vitro MTT cell viability assay was performed. Tartrate-resistant acid phosphatase (TRAP) and actin ring formation assays, as well as immunofluorescence staining were then performed to evaluate osteoclastogenesis. Potential signaling pathways were characterized by western blotting and verified in overexpression experiments. Related factors were examined by western blotting, reverse transcription polymerase chain reaction, electrophoretic mobility shift assay, and co-immunoprecipitation. Ovariectomized mice were used for the in vivo study. Results: TRAP staining showed that shikimic acid significantly inhibited osteoclastogenesis and pit resorption in bone marrow monocytes and RAW264.7 cells, and actin ring formation assays showed that shikimic acid suppressed the bone resorption function of osteoclasts. Furthermore, shikimic acid inhibited the receptor activator of nuclear factor-κB RANK/tumor necrosis factor receptor-associated factor 6 (TRAF6) association, suppressed nuclear factor-κB and mitogen-activated protein kinase signaling pathways, and downregulated nuclear factor of activated T-cell cytoplasmic 1. The expression of osteoclastogenesis biomarkers, including TRAF6, calcitonin receptor, TRAP, cathepsin K, and matrix metalloproteinase-9, was inhibited. In vivo, shikimic acid also significantly ameliorated bone loss and prevented osteoclastogenesis in ovariectomized mice. Conclusion: Shikimic acid inhibited osteoclastogenesis and osteoclast function by blocking RANK ligand-induced recruitment of TRAF6, as well as downstream signaling pathways in vitro. Shikimic acid also reduced ovariectomy-induced osteoclastogenesis and bone loss in vivo.
Feasibility of Coronary
18
F-Sodium Fluoride Positron-Emission Tomography Assessment With the Utilization of Previously Acquired Computed Tomography Angiography
Authors: Kwiecinski Jacek , Adamson Philip D. , Lassen Martin L. , Doris Mhairi K. , Moss Alastair J. , Cadet Sebastian , Jansen Maurits A. , Dey Damini , Lee Sang-Eun , Yun Mijin , Chang Hyuk-Jae , Dweck Marc R. , Newby David E. , Berman Daniel S. , Slomka Piotr J.
Published: December 2018

Background:

We assessed the feasibility of utilizing previously acquired computed tomography angiography (CTA) with subsequent positron-emission tomography (PET)-only scan for the quantitative evaluation of
18
F-NaF PET coronary uptake.

Methods and Results:

Forty-five patients (age 67.1±6.9 years; 76% males) underwent CTA (CTA1) and combined
18
F-NaF PET/CTA (CTA2) imaging within 14 [10, 21] days. We fused CTA1 from visit 1 with
18
F-NaF PET (PET) from visit 2 and compared visual pattern of activity, maximal standard uptake (SUVmax) values, and target to background ratio (TBR) measurements on (PET/CTA1) fused versus hybrid (PET/CTA2). On PET/CTA2, 226 coronary plaques were identified. Fifty-eight coronary segments from 28 (62%) patients had high
18
F-NaF uptake (TBR >1.25), whereas 168 segments had lesions with
18
F-NaF TBR ≤1.25. Uptake in all lesions was categorized identically on coregistered PET/CTA1. There was no significant difference in
18
F-NaF uptake values between PET/CTA1 and PET/CTA2 (SUVmax, 1.16±0.40 versus 1.15±0.39;
P
=0.53; TBR, 1.10±0.45 versus 1.09±0.46;
P
=0.55). The intraclass correlation coefficient for SUVmax and TBR was 0.987 (95% CI, 0.983–0.991) and 0.986 (95% CI, 0.981–0.992). There was no fixed or proportional bias between PET/CTA1 and PET/CTA2 for SUVmax and TBR. Cardiac motion correction of PET scans improved reproducibility with tighter 95% limits of agreement (±0.14 for SUVmax and ±0.15 for TBR versus ±0.20 and ±0.20 on diastolic imaging;
P
<0.001).

Conclusions:

Coronary CTA/PET protocol with CTA first followed by PET-only allows for reliable and reproducible quantification of
18
F-NaF coronary uptake. This approach may facilitate selection of high-risk patients for PET-only imaging based on results from prior CTA, providing a practical workflow for clinical application.
Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function
Authors: Bieber Michael , Schuhmann Michael K. , Volz Julia , Kumar Gangasani Jagadeesh , Vaidya Jayathirtha Rao , Nieswandt Bernhard , Pham Mirko , Stoll Guido , Kleinschnitz Christoph , Kraft Peter
Published: December 2018

Background and Purpose—

Acetylsalicylic acid and clopidogrel are the 2 main antithrombotic drugs for secondary prevention in patients with ischemic stroke (IS) without indication for anticoagulation. Because of their limited efficacy and potential side effects, novel antiplatelet agents are urgently needed. Cilostazol, a specific phosphodiesterase (PDE)-3 inhibitor, protected from IS in clinical studies comprising mainly Asian populations. Nevertheless, the detailed mechanistic role of PDE-3 inhibitors in IS pathophysiology is hardly understood. In this project, we analyzed the efficacy and pathophysiologic mechanisms of a novel and only recently described PDE-3 inhibitor (substance V) in a mouse model of focal cerebral ischemia.

Methods—

Focal cerebral ischemia was induced by transient middle cerebral artery occlusion in 6- to 8-week-old male C57Bl/6 wild-type mice receiving substance V or vehicle 1 hour after ischemia induction. Infarct volumes and functional outcomes were assessed between day 1 and day 7, and findings were validated by magnetic resonance imaging. Blood-brain barrier damage, as well as the extent of local inflammatory response and cell death, was determined.

Results—

Inhibition of PDE-3 by pharmacological blockade with substance V significantly reduced infarct volumes and improved neurological outcome on day 1 and 7 after experimental cerebral ischemia. Reduced blood-brain barrier damage, attenuated brain tissue inflammation, and decreased local cell death could be identified as potential mechanisms. PDE-3 inhibitor treatment did neither increase the number of intracerebral hemorrhages nor affect platelet function.

Conclusions—

The novel PDE-3 inhibitor substance V protected mice from IS independent from platelet function. Pharmaceutical inactivation of PDE-3 might become a promising therapeutic approach to combat IS via inhibition of thromboinflammatory mechanisms and stabilization of the blood-brain barrier.
Anthropomorphizing without Social Cues Requires the Basolateral Amygdala
Authors: Waytz Adam , Cacioppo John T. , Hurlemann Rene , Castelli Fulvia , Adolphs Ralph , Paul Lynn K.
Published: December 2018

Anthropomorphism, the attribution of distinctively human mental characteristics to nonhuman animals and objects, illustrates the human propensity for extending social cognition beyond typical social targets. Yet, its processing components remain challenging to study because they are typically all engaged simultaneously. Across one pilot study and one focal study, we tested three rare people with basolateral amygdala lesions to dissociate two specific processing components: those triggered by attention to social cues (e.g., seeing a face) and those triggered by endogenous semantic knowledge (e.g., imbuing a machine with animacy). A pilot study demonstrated that, like neurologically intact control group participants, the three amygdala-damaged participants produced anthropomorphic descriptions for highly socially salient stimuli but not for stimuli lacking clear social cues. A focal study found that the three amygdala participants could anthropomorphize animate and living entities normally, but anthropomorphized inanimate stimuli less than control participants. Our findings suggest that the amygdala contributes to how we anthropomorphize stimuli that are not explicitly social.
Checklist of the endemic vascular plants of Paraguay
Authors: PEÑA CHOCARRO MARÍA DEL CARMEN , DE EGEA JUANA
Published: December 2018

We present a list of endemic plants of Paraguay, which includes 374 taxa from 52 families and 162 genera based on the revision of primary data (herbarium collections). Synonyms, habit, distribution in Paraguay and all the voucher specimens seen or cited in recent bibliographies or in the consulted databases are provided for each taxon. A brief analysis of the diversity and importance of this endemic flora is presented. A list of excluded species, which were considered as endemics in previous publications, is also included.
Long-distance introduction: first New World record of Stevenia deceptoria (Loew) and a key to the genera of New World Rhinophoridae (Diptera)
Authors: MULIERI PABLO RICARDO , PATITUCCI LUCIANO DAMIÁN , MARILUIS JUAN CARLOS , PAPE THOMAS
Published: December 2018

The Rhinophoridae are a small family with about 150 named species worldwide. Seventeen species of this family are known from the Neotropical Region: 14 species of Bezzimyia Townsend; the monotypic genera Shannoniella Townsend and Trypetidomima Townsend; and the Palaearctic immigrant Melanophora roralis (Linnaeus) (Pape & Arnaud 2001; Pape in press). Undescribed species of Bezzimyia and Shannoniella as well as species that cannot be assigned to any of the currently described genera are known (P. Cerretti, pers. comm., & TP, unpubl.), and the Neotropical rhinophorid fauna is still superficially known.
Description of the larva of Holocentropus insignis Martynov 1924 (Trichoptera: Polycentropodidae) with notes on biology and distribution
Authors: BOONSTRA HARRY , RINNE AKI , KUBIAK MARTIN , WIBERG-LARSEN PETER
Published: December 2018

The hitherto undescribed larva of Holocentropus insignis Martynov 1924 was collected in Denmark, the Netherlands, and Finland. Based on larval morphology and DNA association with adults, we were able to distinguish the larva of H. insignis from other Holocentropus species known to occur in Europe and confirm its identification. We provide morphological features to separate H. insignis from the other known species within the genus and give an updated key to all known European larvae of Holocentropus. Extensive notes on the life cycle, biology, and distribution of H. insignis are given.
Resolving the status of the genera Gastrophysus and Geneion in the family Tetraodontidae (Teleostei: Tetraodontiformes)
Authors: JELKS HOWARD L.
Published: December 2018

Maintaining a current list of valid names and taxonomy for biodiversity is an ever-increasing challenge for the Integrated Taxonomic Information System (ITIS 2017). Advances in molecular techniques and the discovery of many cryptic taxa have dramatically increased the number of species and resulted in revised interpretation of phylogenetic relationships. Occasionally it is necessary to resolve discrepancies in nomenclature to reflect current knowledge. Taxa that are harvested for consumption are particularly in need of name stability. In this paper evidence is presented for the use of the puffer genus Takifugu Abe 1949 over Gastrophysus Müller 1843 and Amblyrhynchote Bibron in Duméril 1855 over Geneion Bibron in Duméril 1855.
Designation of a neotype for Clorindaia hecaloides Linnavuori (Hemiptera: Cicadellidae: Deltocephalinae: Faltalini)
Authors: PARADELL S. , ZAHNISER J.N.
Published: December 2018

Linnavuori (1975) established the genus Clorindaia with the newly described species C. hecaloides Lv. designated as the type species of the genus. The genus currently includes five valid species, known from Brazil, Paraguay, and Argentina. C. hecaloides was described based on only one female specimen from Argentina, Formosa Prov., Clorinda. Linnavuori (1975) indicated that the holotype was deposited at the Museo de La Plata. However, extensive searches for the specimen at this institution and also at the American Museum of Natural History, at the Ohio State University Collection, and at US National Museum of Natural History have not recovered the specimen. Blocker & Fang (1992) also reported unsuccessful searches for the holotype and for a parasitized female specimen collected in Chile, reported by Linnavuori & DeLong (1977). Because the holotype appears to have been lost and because the description was based on a female which does not always provide unambiguous diagnosable characters at the species level in this group of leafhoppers, the identity of this species based on the original description unclear.
Inserting professionals and professional organizations in studies of wrongdoing: The nature, antecedents and consequences of professional misconduct
Authors: Gabbioneta Claudia , Faulconbridge James R , Currie Graeme , Dinovitzer Ronit , Muzio Daniel
Published: December 2018

Professional misconduct has become seemingly ubiquitous in recent decades. However, to date there has been little sustained effort to theorize the phenomenon of professional misconduct, how this relates to professional organizations, and how this may contribute to broader patterns of corruption and wrongdoing. In response to this gap, in this contribution we discuss the theoretical and empirical implications of analyses that focus on the nature, antecedents and consequences of professional misconduct. In particular, we discuss how the nature of professional misconduct can be quite variegated and nuanced, how boundaries between and within professions can be either too weak or too strong and lead to professional misconduct, and how the consequences of professional misconduct can be less straightforward than normally assumed. We also illuminate how some important questions about professional misconduct are still pending, including: how we define its different organizational forms; how it is instigated by the changing nature of professional boundaries; and how its consequences are responded to in professional organizations and society more widely.
A closer look at the positive crossover between supervisors and subordinates: The role of home and work engagement
Authors: Rofcanin Yasin , Las Heras Mireia , Bosch Maria Jose , Wood Geoffrey , Mughal Farooq
Published: December 2018

How can we explain the crossover of positive experiences from supervisors to their subordinates? Drawing on crossover research and social learning theory (SLT), our main goal in this study is to explore mechanisms and boundary conditions to understand how positive crossover occurs from supervisors to their subordinates. We focus on the nature and foundations of positive crossover in the domains of work and home, and explore the downstream consequences for subordinates’ domain-specific outcomes. Using matched supervisor–subordinate data, the results of multi-level analyses demonstrated that perceived organization support (POS) of subordinates does not impact the positive association between supervisors’ and subordinates’ work engagement. However, family supportive supervisor behaviours (FSSBs), as perceived by subordinates, strengthen the positive association between supervisors’ and subordinates’ home engagement. Importantly, subordinates’ work and home engagement explains why supervisors’ state of engagement in work and home domains, respectively, influences subordinates’ functioning in work and home domains, underscoring a trickle-down model. We contribute to crossover research through demonstrating that crossover occurs from supervisors to their subordinates in work and family domains. Firstly, we highlight the role of relational mechanisms as boundary conditions of crossover process. Secondly, we extend the understanding of how crossover impacts on subordinates’ key outcomes at work and home. Thirdly, we expand crossover research in an understudied context, Chile. In doing so, we contribute to the literature on hierarchical market economies, through providing further insights on the operation of interpersonal ties and relations in such contexts.
Correctional Officer Fatalities in Line of Duty During 2005 to 2015: A Survival Analysis
Authors: Liu Weiwei , Taylor Bruce
Published: December 2018

Using correctional officer data from the National Law Enforcement Officers Memorial (NLEOMF) database, we describe the characteristics of U.S. correctional officers killed in line of duty in the past decade, and explore how the hazard probability changed over the life span and factors related to these changes. Survival analysis results show that several demographic characteristics were significantly related to changes in hazard probabilities. Study results provided the most recent statistics on profiles of U.S. correctional officers killed in line of duty. Findings have implications for prevention programs aimed at increasing correctional officer safety.
The Legal and Illegal Use of Force by Prison Officers in Ukraine
Authors: Symkovych Anton
Published: December 2018

Although prison order rarely rests on naked force, its availability defines a prison. A penological truism holds that officers’ deployment of force signals a breakdown in order, not normality. However, is the truism universally valid? Adding evidence from a former Soviet bloc country, the study examines the place of force in officers’ daily work in a men’s medium-security prison in Ukraine. Drawing on a semiethnographic study, the findings show that even though availability of force was central to preventing escapes and securing prisoner compliance, its actual deployment was relatively rare. Officers’ consideration and actual use of both legal and illegal force depended on legal ramifications, the position of the superiors, and prisoner reaction. It also reflected their views on the adequacy of formal penal power and legitimacy of force for corrective purposes.
The European Works Council as a management tool to divide and conquer: Corporate whipsawing in the steel sector
Authors: Aranea Mona , González Begega Sergio , Köhler Holm-Detlev
Published: December 2018

In large, highly internationalized companies, local sites of production have to contribute to the competitiveness of the corporation while decision-making is directed ever further away from their influence. The article examines how inter-plant competition, called management whipsawing, has changed at the transnational steel company ArcelorMittal over 12 years. The authors take an explicitly Gramscian perspective, as they study the role of coercion and consent in the staging of inter-plant competition. The analysis is based on 45 qualitative interviews with company managers and employee representatives in Spain, Germany, Belgium and Luxembourg, carried out in two phases, from 2004 to 2006 and 2014 to 2016. The aim is to understand how management can integrate central arenas for employee involvement into their strategies with regard to inter-plant competition. A central finding of this longitudinal case study is that the European Works Council (EWC) is essential in the construction of employee consent to labour competition.
To What Extent Do Practitioners Need to Treat Stereotypy During Academic Tasks?
Authors: Cook Jennifer L. , Rapp John T.
Published: December 2018

Researchers frequently argue that a child’s engagement in stereotypy may compete with his ability to acquire academic skills, engage in appropriate social interactions, or both; however, few studies have directly tested these suppositions. We used a five-phase assessment to evaluate the extent to which behavioral interventions with a progressively greater number of components were necessary to decrease stereotypy and increase correct responding during academic instructions for five children diagnosed with autism spectrum disorders. For one participant, stereotypy decreased when instructors provided standard instruction without specific intervention for stereotypy. For two participants, stereotypy decreased when instructors provided standard instruction plus antecedent intervention for stereotypy with continuous music. For another participant, stereotypy decreased when instructors provided enhanced consequences for correct responding during standard instruction without either antecedent or consequent intervention for stereotypy. For the final participant, stereotypy decreased and correct responding increased when instructors provided standard instruction and consequent intervention for stereotypy.
To know or not to know: Should crimes regarding photographs of their child sexual abuse be disclosed to now-adult, unknowing victims?
Authors: Ost Suzanne , Gillespie Alisdair A
Published: December 2018

This paper considers the unexplored question of whether unaware crime victims have rights or interests in knowing and not knowing information pertaining to the crime(s) committed against them. Our specific focus is on whether crimes regarding abusive images should be disclosed to the now-adult victims of child sexual abuse who feature in them. Because these issues have not been addressed in the victimology or criminological literature, we utilise literature in another discipline – healthcare ethics and law – to inform our analysis. Through engaging with the debate on the right to know and not to know information concerning one’s genetic status, we develop a conceptualisation of the issues regarding unknowing abusive image victims. A rights-based conceptualisation proves to be largely inappropriate; we contend that, instead, it would be more productive to look to unknowing abusive image victims’ interests. We argue that the interests at stake are grounded in autonomy and/or spatial privacy, and that to find a way to resolve the disclosure dilemma, these interests must be considered alongside consequentialist concerns; disclosing information regarding abusive images could empower now-adult victims but could well cause them (further) harm. Finally, we consider the implications of our analysis for victimology.
CD44 and CD24 Expression and Prognostic Significance in Canine Mammary Tumors
Authors: Rogez Bernadette , Pascal Quentin , Bobillier Audrey , Machuron François , Lagadec Chann , Tierny Dominique , Le Bourhis Xuefen , Chopin Valérie
Published: December 2018

CD44+/CD24– phenotype has been used to identify human and canine mammary cancer stem-like cells. In canine mammary tumors, CD44+/CD24– phenotype has been associated with high grade and lymph node infiltration. However, several studies have reported opposing results regarding the clinical significance of phenotypic groups formed by the combination of CD44 and CD24 in both human and canine mammary tumors. So far, no study has investigated the correlation between these phenotypes and survival in dogs. The aim of this study was to investigate the expression and distribution of CD44 and CD24 in canine mammary carcinomas and to correlate them with histological diagnosis and survival in a well-characterized cohort. Immunohistochemistry was performed in 96 mammary carcinomas with antibodies against CD44 and CD24. Expression of CD44+ and CD44+/CD24– phenotype was detected in 75 of 96 (78%) and 63 of 96 (65.6%) carcinomas, respectively. Their expression was associated with tumor type, occurring more often in tubular complex carcinomas than in solid carcinomas. CD44+/CD24– phenotype was associated with a better overall survival ( P = .001). CD24+ expression was detected in 52 of 96 tumors (54%) and CD44–/CD24+ phenotype in 39 of 96 tumors (40.6%). Both were associated with poor clinicopathological parameters (high grade, and emboli). No correlation with overall survival was observed. CD44+/CD24– expression was associated with a better prognosis and occurred at high frequency and high level, indicating that this phenotype is not suitable to detect cancer stem cells in canine mammary carcinomas. Although further studies are needed, our results suggest that CD24 may constitute a valuable marker of poor prognosis for canine mammary carcinomas.
Mycotic Rhinitis and Sinusitis in Florida Horses
Authors: More Sunil Nivrutti , Hernandez Oscar , Castleman William L.
Published: December 2018

Rhinitis and sinusitis caused by fungal pathogens were studied in biopsy samples submitted from 52 horses distributed throughout subtropical and tropical regions of Florida. Methods included routine histopathology as well as polymerase chain reaction (PCR) with panfungal/panoomycete primers and DNA sequencing on extracted DNA (DNA barcoding). Granulomatous, pyogranulomatous, and fibrinopurulent lesions in nasal and sinus mucosa were associated with signs of upper airway obstruction and noise as well as nasal discharge. Morphologic and histochemical assessment of cases identified 31 cases of zygomycosis/pythiosis plus 1 mixed infection case, 16 cases of phaeohyphomycosis with 2 additional mixed infection cases, and 3 cases caused by other fungi. Morphologic evidence of Aspergillus sp. infection as a superficial copathogen was found in 2 of the mixed fungal infection cases. PCR and DNA sequencing facilitated identification of fungal pathogens in 11 of 52 cases (21%). No evidence of oomycete infection was found. Histomorphologic features of previously unrecognized forms of equine rhinitis/sinusitis were described, including those caused by Flavodon flavus, Curvularia lunata, Exserohilum rostrata, Alternaria alternata, Alternaria sp., Cladophialophora bantiana, Fusarium solani, and Toxicocladosporium irritans. PCR and DNA sequencing using panfungal and oomycete primers with DNA from formalin-fixed and paraffin-embedded specimens successfully identified the pathogen in phaeohyphomycosis (7/18 cases, 39%), zygomycosis/pythiosis (1/32 cases, 3%), and other nonpigmented fungal infections (3/3 cases, 100%). Zygomycosis and phaeohyphomycosis were the most common forms of fungal rhinitis found in Florida horses.
Abrasive wear behaviour of cast Al–Si–Mn alloys
Authors: Çetin Melik
Published: December 2018

In this paper, the effect of manganese (wt%) and size of the Al2O3 abrasive grains of abrasive wear behaviours of Al–Si–(0.16–0.76%) Mn alloy was examined. Abrasive wear experiments were conducted against abrasive Al2O3 paper grains with diameters in the variety of 38–250 µm, under the normal load range of 10, 20 and 30 N and the sliding velocity of 0.1 m s−1. Wear measurements have shown that the wear rate of the material is dependent on the manganese content and the abrasive grain size. The best wear resistance is in the content of 0.73 Mn, which is associated with increased toughness and strength. The Al–Si casting alloy which had 0.73% Mn content exhibited lower wear rate than the Al–Si–0.16/0.22/0.23% Mn alloys after scoured on fine abrasive Al2O3 grains (<65 µm). Wear experiments achieved on Al2O3 grains having sizes greater than 65 µm revealed that, the cast Al–Si– alloy which had 0.73% Mn content had lower wear rate than the cast Al–Si–0.16/0.22/0.23% Mn alloys.
Speaking on behalf of oneself and others: Negotiating speaker identities in journalistic discourse on refugee activism in Sweden
Authors: Persson Gustav
Published: December 2018

Journalism has an important role in making political participation visible to the public. In representing the voices of the public, journalism produces discourses on democratic engagement that tell us a great deal about the norms of how these discourses conceive of practices of political engagement. The aim of this article is to study the ways in which speaker identities are given to and taken by migrant activists participating in Swedish radio interviews. Employing Goffman’s concept of footing, this article shows that there are conflicting speaker identities that the activists are adopting and are given by the framework of the radio interviews. The main conflict in how the speaker identities are made up is based on the negotiations around how the activists are talking about themselves or about others. The article further shows how talking about others in a public discourse such as journalism requires speakers to make difficult choices in how to represent oneself as a speaker, and that such choices might stand in conflict with a news discourse’s preferred authentic and experiential identity of its sources.
Progress and Updates in Stroke Research: Introduction to the Special Issue on Stroke
Authors: Luo Yu , Zhang John H. , Sanberg Paul R. , Portis Samantha M.
Published: December 2018

As guest editors of this special issue, we are delighted to present 13 articles that discuss advances in stroke research including translational stroke research, stroke research milestones, and proposals for future directions. Stroke is a major cause of disability, and, according to the Centers for Disease Control and Prevention, is the fifth leading cause of death in the US alone. Possible factors contributing to stroke pathogenesis are elucidated and possible treatment modalities are explored in the following special issue of Cell Transplantation.
What’s Love Got to Do With It? Team Entrepreneurial Passion and Performance in New Venture Teams
Authors: Santos Susana C. , Cardon Melissa S.
Published: December 2018

We integrate literatures on entrepreneurial passion, shared emotions, and group identities to extend a conceptual model of team entrepreneurial passion (TEP). We delineate mono-focal, complete, and incomplete poly-focal TEP, and examine how each type and focus of TEP is related to team performance. We test our hypotheses with 73 new venture teams. Results reveal that TEP occurs in 61 teams in our sample (23 mono-focal, 26 complete poly-focal, 12 incomplete poly-focal). In terms of focus, TEP for inventing and developing are positively related to team performance. Concerning type, mono-focal and complete poly-focal TEP are the most beneficial for team performance.
Biography Breaks in the Music Classroom
Authors: May Brittany Nixon , Miner Amy Baird , Young Terrell A.
Published: December 2018

Children’s picture book biographies on composers and musicians can prompt powerful music learning experiences. Biography breaks are the reading aloud of a picture book biography and the questions or activities the teacher engages students in while and after reading the book. In the music classroom, biography breaks can be used with children of all ages to introduce students to composers, musicians, music elements and concepts, music vocabulary, music genres and styles. Biography breaks provide a groundwork for discussing the historical, social, and cultural context of music, as well as a catalyst for engaging students in meaningful music experiences creating, performing, responding to, and connecting with music.
Key stakeholders’ perceptions about school improvement strategies in UAE
Authors: Al Ahbabi Nafla Mahdi
Published: December 2018

This article reports on findings related to possible strategies of improving school effectiveness in Abu Dhabi from the perspectives of their stakeholders’ perceptions, namely, principals, teachers, students, and parents. This study considered 18 strategies of meaningful school improvement (SI) to help align Abu Dhabi schools to international standards by assessing their policies, management, and performance as well as the roles played by each of the four groups of stakeholders. The close examination of these stakeholders’ perceptions about change and improvement made it possible to identify five paramount strategies that may contribute to improving schools within the UAE secondary education system and perhaps leading toward more significant reform alignment. These are a participative reflective leadership, a common ambitious vision, a healthy learning environment, high expectations for success, and differentiated instructional strategies. The data indicated that schools could not be improved unless all the school parties are jointly involved as catalysts for change in forging the school’s vision, environment, and prospects for success. The data were taken from research conducted in the Emirate of Abu Dhabi, the capital of the United Arab Emirates.
U.S. Demand for European Soccer Telecasts: A Between-Country Test of the Uncertainty of Outcome Hypothesis
Authors: Nalbantis Georgios , Pawlowski Tim
Published: December 2018

Demand studies in sports relying on within-country settings are suggestive of cross-continental differences with regard to game uncertainty preferences. While North Americans seem to have a preference for tighter games, Europeans prefer games involving a favorite. Our study is the first to test this suggested pattern in a between-country setting with individual-level data. In contrast to the existing evidence from within-country settings, our demand models show that U.S. consumers do not value game uncertainty when watching European soccer. This finding suggests that, when examining the same sport, European and North American consumers’ preferences seem to be quite similar.
Reaching the Right People: Reflexive Practice to Support Effective Recruitment, Participation, and Engagement in Research With Communities Affected by Stigma
Authors: Stevenson Jacqui , Keogh Peter , Smith John , West Elizabeth
Published: December 2018

Recruiting participants to qualitative studies is often a challenge—reaching the right people, and the right people choosing to participate, is a primary consideration for researchers. For research on HIV, as a condition which continues to be stigmatized, this can be magnified. However, being part of the HIV voluntary sector and occupying a role of “HIV advocate” can provide routes to overcome this challenge. Using the example of the researcher’s transition from voluntary sector worker to academic PhD researcher, this article explores how recruitment can be facilitated by utilizing personal and professional networks and how, in turn, this can present new challenges in reaching participants who are not “research regulars,” who are experienced in participating in qualitative research. It further explores reflexive methodologies as applied to participatory research on HIV and aging as it affects women in the UK and asks how the roles of “advocate” and “researcher” complement and challenge one another. Reflexive practice and an analysis of the researcher’s motives and how this impacts on recruitment, participation, and dissemination are considered. A three-part approach to reflexively engaging with participants’ questions is put forward. This provides a new perspective on participatory approaches in relation to research recruitment specifically.
Modal property of base-isolated high-rise structure considering soil–structure interaction effect
Authors: Du DS , Wang SG , Liu WQ , Shi S , Lee CP , Xu Jun
Published: December 2018

A simplified methodology is rigorously studied in this article to analyze the modal properties of base-isolated high-rise structures with dynamic soil–structure interaction being considered. The proposed methodology is developed based on a more reasonable 2-degree-of-freedom model and the existing simplified methodology which is only applicable for non-isolated structures. The base-isolated structure model with 2 degrees of freedom is supported by swaying and rocking springs and by the corresponding dashpots. Rigorous mathematical derivation is performed, and closed-form formulas of natural periods, modes, and modal damping ratios are derived. Furthermore, the overall accuracy of the proposed methodology was checked against the results of the rigorously derived complex eigenvalue approach proposed by Constantinou and Kneifati. A parametric study is also conducted on the soil–structure interaction effects of base-isolated structures, which indicates that tall and slender structures with stiff isolation systems are more affected by soil–structure interaction effects in comparison to flexible superstructures. The proposed method provides a feasible way to evaluate the soil–structure interaction effects of base-isolated structures efficiently during the schematic design phase.
Gear fault diagnosis using Autogram analysis
Authors: Afia Adel , Rahmoune Chemseddine , Benazzouz Djamel
Published: December 2018

Rotary machines consist of various devices such as gears, bearings, and shafts that operate simultaneously. As a result, vibration signals have nonlinear and non-stationary behavior, and the fault signature is always buried in overwhelming and interfering contents, especially in the early stages. As one of the most powerful non-stationary signal processing techniques, Kurtogram has been widely used to detect gear failure. Usually, vibration signals contain a relatively strong non-Gaussian noise which makes the defective frequencies non-dominant in the spectrum compared to the discrete components, which reduce the performance of the above method. Autogram is a new sophisticated enhancement of the conventional Kurtogram. The modern approach decomposes the data signal by Maximal Overlap Discrete Wavelet Packet Transform into frequency bands and central frequencies called nodes. Subsequently, the unbiased autocorrelation of the squared envelope for each node is computed to select the node with the highest kurtosis value. Finally, Fourier transform is applied to that squared envelope to extract the fault signature. In this article, the proposed method is tested and compared to Fast Kurtogram for gearbox fault diagnosis using experimental vibration signals. The experimental results improve the detectability of the proposed method and affirm its effectiveness.