bluuebunny/crossref_metadata_2025 huggingface dataset:
An Experimental Bacteriostasis of the Banxiaxiexin Decoction and 7 Kinds of Single Taste Traditional Chinese Medicine on Helicobacter Pylori Resistant Strains in Vitro
Authors:   Department of Traditional Chinese Medicine, The Affiliated Hospital of Beihua University, Jilin, China, Qu Zhiwei , Yu Mingjun , Zhang Airong , Wang Ailin , Shun Liyuan
Published: May 2022

Objectives: To research experimental bacteriostasis on the Banxiaxiexin decoction and 7 kinds of single taste Traditional Chinese Medicine (TCM) for Helicobacter pylori resistant strains in vitro. Methods: Collecting specimens of gastric mucosa in patients with upper gastrointestinal disease, separated and identified 8 strains of Hp resistant strains, the E-test methods of metronidazole and clarithromycin, drug resistance status of amoxicillin, selected eight strains of clinical drug resistance strains; Using liquid dilution method to determine the Banxiaxiexin decoction and 7 kinds of single Chinese medicine clinical drug-resistant strains of 8 strains of antibacterial effect in vitro. Results: Banxiaxiexin decoction MIC is 0.31 mg/ml, MIC of Radix scutellariae is 0.09 mg/ml, Rhizoma coptidis MIC 0. 16 mg/ml, Glycyrrhizin realness MIC 0. 31 mg/ml, Ginseng MIC 0. 75 mg/ml, there are four of seven kinds of single taste Traditional Chinese Medicine of TCM has bacteriostatic action, the order of antibacterial strength: Scutellaria baicalensis>Coptis chinesis>Glycyrrhizin realness >Ginseng, three kinds of Pinellia, Jujube and dry Zingibe in vitro for H. P ylori no inhibition, the method of MIC with liquid dilution in this decoction were determined, the decoction of resistant isolates average MIC isolates was 0.20±0.09mg/ml, the results showed that this decoction have stronger antibacterial effect on eight kinds of drug resistant strains in vitro. Banxiaxiexin decoction and 4kinds of single taste TCM have stronger antibacterial effect on drug resistant strains in vitro. Conclusion: Banxiaxiexin decoction and 4 kinds of single TCM have strong bacteriostatic effect on the bacteria resistance of Helicobacter pylori strains in vitro, therefore, we suggest that this decoction could be used as an effective method in the treatment of resistant HP associated gastritis.
Valsartan/Sacubitril for Treatment of Hfref: A Single Center's Paradigm
Authors:   Department of Cardiology, St. Vincent Hospital and Heart Center, Indianapolis, USA, Lisa Morris Kathleen , Shmukler Edward , Schmit Ann , Preet Chaudhry Sunit , Mary Norine Walsh Mary , Ravichandran Ashwin
Published: May 2022

PARADIGM-HF compared valsartan/sacubitril (ARNI) with enalapril in symptomatic patients with heart failure with reduced ejection fraction (HFrEF) (1). It was stopped early after the boundary for overwhelming benefit in favor of ARNI had been reached. Patients taking ARNI had decreased symptoms, risk of HF hospitalization and all-cause and cardiovascular mortality. We sought to describe our center’s initial year of experience with this novel agent. A retrospective chart review was completed of all patients in our advanced HF clinic who were prescribed ARNI between August 2015 and October 2016. Outcomes data were collected through August 2017. Consistent with the Food and Drug Administration (FDA) indication, patients treated had NYHA class II, III or IV HF symptoms with LVEF of 35% or less. The majority of those prescribed ARNI were able to initiate the medication. However, a significant proportion of patients (26.4%) had to discontinue ARNI due to a variety of reasons, most commonly symptomatic hypotension (31.0%) and insufficient insurance coverage (31.0%). Only 30.5% of patients successfully treated reached the maximum dose; in 85% of these patients, hypotension limited up titration of therapy. PARADIGM-HF demonstrated benefit of ARNI therapy over enalapril in patients with HFrEF and therapy was well tolerated. In our real world experience, hypotension and lack of insurance coverage limited utilization. Further experience with this therapy in a non-trial setting will inform optimal patient selection and titration strategies. Expanded insurance coverage will be crucial to allow for patient access.
Abnormal Weight Among University Students in the Kingdom of Bahrain (2018): Prevalence, Factors, Predictions, and Recommendations
Authors:   Department of Mathematics and Natural Sciences, Prince Mohammad Bin Fahd University, Dhahran, Saudi Arabia, Jaoua Nizar , Woodman Alexander , Amini Majeed
Published: May 2022

Over the past two decades, the Kingdom of Bahrain has seen an increase in weight in a growing number of people. Experts in the field determined that it is due to a lack of exercise and poor dietary habits. The problem has reached extremely high records of obesity; 37% for females and 30% for males. The statistics were based on a cross-sectional study of 414 volunteers at a local shopping mall. The goal of this primary data analysis was to determine the current prevalence of weight abnormalities. The findings were used to predict the trend of such abnormalities among the sub-population of university students in the Kingdom of Bahrain. The analysis, done in 2018, was based on 1,100 surveys collected from subjects in the central universities in the Kingdom of Bahrain including the University of Bahrain, Ahlia University, University of Bahrain, Arabian Gulf University, Applied Science University, AMM International University, Arab Open University, and Bahrain Polytechnic. The research was conducted over a period of several months. The authors developed surveys in both Arabic and English and randomly selected participants aged between eighteen and twenty-five among full-time students from major universities in the Kingdom of Bahrain. The standards of these weight issues, including obesity, overweight and underweight issues were determined with the use of the International Classification Index, a diagnostic tool used for health management. It is managed and prescribed by the World Health Organization. Based on the Chi-square test, the results strongly depended on the gender, age, and the extent of exercise performed on a weekly basis. As a result, a multinomial logistic regression involving these factors was used to compare the trends and predict the highest and lowest probabilities of each abnormal weight. For example, the male students, aged twenty-two or older who exercise less than one hour a week, were the most likely to be obese and overweight; about 20% and 42% chance, respectively. However, the students most probable to be underweight (about 11%) were those females; aged eighteen or nineteen who exercise less than one hour a week.
Persistent Pulmonary Atelectasis in Patient with Rheumatoid Arthritis Treated with High-Flow Therapy and High-Frequency Chest Wall Oscillation
Authors:   Division of Respiratory Physiopathology, Monaldi Hospital, Naples, Italy, Annunziata Anna , Sciarrillo Elena , Lanza Maurizia , Fiorentino Giuseppe
Published: May 2022

Rheumatoid arthritis is a systemic inflammatory disorder that affects ∼1-2% of the population. Although a progressive destruction of cartilage and bone is the main presentation, extra-articular manifestations can occur in about 40% of patients during the course of their disease and are associated with significant morbidity and increased mortality. Pulmonary complications can frequently occur in these patients, although not always clinically recognized. We present a case of 60-year-old woman suffering from rheumatoid arthritis came to our department for the presence of exertional dyspnea, cough with poor mucous expectoration, chest pain and worsening of daytime asthenia. At a chest x-ray, evidence of right basal pulmonary atelectasis, for which she had practiced antibiotic therapy with persistence of symptomatology and pulmonary atelectasis. Chest CT showed parenchymal consolidation. The patient was treated with antibiotics and rehabilitation therapy, bronchial endoscopy, with persistence of pulmonary atelectasis. She started nasal high-flow therapy but in the seventh day appears epistaxis. For this reason, she suspended treatment with NHF. At the next rehabilitation session, for the recurrence of epistaxis, an otorhinolaryngology visit was performed that confirms the presence of nasal varices. Therefore, the patient started high-flow therapy with a mouthpiece with the use of High Frequency Chest Wall Oscillation. At the end of rehabilitative treatment we observed clinical and radiological improvement.
Evaluation of Eeg Pattern and Seizure Types of Genetic Dysmorphic Syndromes: Report of 50 Patients and Review of the Literature
Authors:   Dr. Behçet Uz Children’s Hospital, Department of Pediatric Neurology, University of Health Sciences, Izmir, Turkey, Gürbüz Gürkan , Hazan Filiz , Edizer Selvinaz , Toklu Baysal Bahar , Yilmaz Ünsal , Ünalp Aycan
Published: May 2022

Many chromosomal anomalies manifest with epilepsy. Only few typical EEG and seizure type have been identified in genetic syndromes. Identification of typical seizure and EEG findings of certain genetic syndromes may serve as a guide for genetic analysis. This study aims to find typical EEG paterns of spesific genetic syndromes. The study enrolled 50 patients aged 0-16 years with a diagnosis of epilepsy and genetic syndrome in between 2014-2017 at the Dr. Behçet UZ Children’s Hospital Pediatric Neurology and Medical Genetics departments. Patients' characteristics and dysmorphic features were retrieved from Medical Genetic outpatient clinic patient files, while seizure type, epileptic syndromic classification, EEG and brain MRI findings, age at onset and frequency of seizure were determined from pediatric neurology follow-ups. Fifty patients (29 girls) with a mean age of 6.52 ±3.67 years (max=16, min=1) were enrolled. Twenty-two patients had microdeletion-duplication (44%), 12 had chromosomal anomalies (24%) and 16 had monogenic syndrome (32%). Pathology was present in the EEGs of 40 patients (80%). Focal epileptic disorder was determined in 28 subjects (56%), epileptic encephalopathy in 7 (14%), and generalized epileptic disorder in 5 (10%) Identification of seizure type and EEG pattern specific to each genetic dysmorphic syndrome may give clues to clinicians in recognizing these syndromes. However, in order to detect other specific EEG patterns, there is a need for multicentre studies with more patients.
ROC Analysis Identiﬁes Baseline and Dynamic NLR and dNLR Cut-Oﬀs to Predict ICI Outcome in 402 Advanced NSCLC Patients
Authors:   Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano, Italy, Novello Silvia , Migliaretti Giuseppe , Galetta Domenico , Tabbò Fabrizio , Montrone Michele , Alemanni Alessandra , Genestroni Silvia , Stura Ilaria , Vavalà Tiziana , Buosi Roberta , Soto Parra Hector , Lunghi Alice , Borra Gloria , Numico Gianmauro , Pizzutilo Pamela , Mariniello Annapaola , Carnio Simona
Published: May 2022

Background: Neutrophil-to-Lymphocyte Ratio (NLR) and derived Neutrophils-to-(Leukocytes minus neutrophils) Ratio (dNLR) have been proposed as possible biomarkers of response to immune checkpoint inhibitors (ICI). However, in non-small cell lung cancer (NSCLC) studies, various NLR and/or dNLR cut-oﬀs have been used, manly based on previous reports on melanoma. Methods: In this Italian multicenter retrospective study, NLR, dNLR, platelet-to-lymphocyte ratio, albumin, and lactate dehydrogenase (LDH) were longitudinally assessed in patients with stage IV non-small cell lung cancer (NSCLC) treated with ICI. The primary objective was to evaluate if baseline parameters predicted response to ICI, using Receiver Operating Characteristic (ROC) curves. Secondary endpoint was to evaluate if dynamic changing of NLR and dNLR also predicted response. Results: Data of 402 patients were collected and analyzed. Among the baseline parameters considered, NLR and dNLR were the most appropriate biomarkers according to the ROC analyses, which also identiﬁed meaningful cut-oﬀs (NLR = 2.46; dNLR = 1.61). Patients with low ratios reported a signiﬁcantly improved outcome, in terms of overall survival (p = 0.0003 for NLR; p = 0.0002 for dNLR) and progression free survival (p = 0.0004 for NLR; p = 0.005 for dNLR). The role of NLR and dNLR as independent biomarkers of response was conﬁrmed in the Cox regression model. When assessing NLR and dNLR dynamics from baseline to cycle 3, a decrease ≥1.04 for NLR and ≥0.41 for dNLR also predicted response. Conclusions in our cohort, we conﬁrmed that NLR and dNLR, easily assessable on peripheral blood, can predict response at baseline and early after ICI initiation. For both baseline and dynamic assessment, we identiﬁed clinically meaningful cut-oﬀs, using ROC curves.
Herpes Simplex Virus and Alzheimer’s Disease: The Present State of Clinical Evidence
Authors:   Medical Department, Aché Pharmaceuticals Laboratories S. A., São Paulo, Brazil, Carlos Amedeo Vattimo Antonio , Zung Stevin , Bauer Bannach Andrea , Luiza Porto Viana Analia , Papaiordanou Francine , Pacheco de Oliveira Gabriela , Toscano Kasabkojian Stephanie
Published: May 2022

Alzheimer´s disease (AD) and dementia have a probably multifactorial pathogenesis and, accordingly to several studies, human herpes simplex virus type 1 (HSV-1) infection may be related. The purpose of this review is to assess the updated clinical evidence towards the association between herpes infection and AD. We performed a PubMed/MEDLINE database research and included in this review randomized clinical trials on the subject of antivirals effectiveness and AD, and observational case-control studies and observational cohort studies regarding AD diagnosis (using clinical and/or histological methods) and HSV-1 detection (using molecular biology or immunohistochemical techniques). A total of 23 case-control and 3 cohort studies met the predetermined inclusion criteria. The results showed that AD was associated with HSV-1 in 22 of the 26 included studies, with most of them confirming that herpes infection is more prevalent in AD patients, when compared to control patients. A possible link between HSV-1 and AD was discussed and many different interpretations and hypothesis were considered. Evidence from observational studies suggests a possible relationship between the two conditions, but the role of HSV-1 infection in the pathogenesis of AD is not completely understood yet. Well-designed and large clinical trials are necessary to endorse this hypothesis and to consider the use of antiviral drugs as a potential alternative for prevention or reduction in the progression rate of AD in the future.
An Insight into ACE2 Expression Associated Complexities of COVID-19 and the Possible Vaccine Strategies to Control Viral Entry into Host Cells
Authors: Mahmud Syfuddin Hasan , Atkia Fariha Khandaker
Published: May 2022

The first detected COVID-19 virus in China in late December 2019, has now spread to over 200 countries and territories across the globe. As it is a novel virus, in course of time, new symptoms and new complexities in patients have arisen, which demand immediate attention. This ambiguous, fast mutating nature and strain variations of SARS CoV2 have hindered the way of vaccine development. However, recognizing this new virus as a member of coronavidae family and its similarity with previously prevailed SARS-Cov virus has advantages in order for its further characterization and identification of the route of entry. Hence, this review aims at providing an overview of the viral entry pathway and explaining the reasons behind the vulnerability of an individual based on his/her age, sex, weight, other existing diseases and genetic make-up. It will also try to explicate various newly emerged symptoms of COVID-19 from the perspective of cytokinin storm theory. Furthermore, it summarizes all the therapeutic strategies based on preventing virus entry, some of which are already developed or under trial or yet confined in theory using currently published literature, scientific reports and research articles about SARS-CoV2. This review will help better understand the COVID-19 complicacies with latest concepts on therapeutic strategies against SARS-CoV2.
Interaction of Squid (Dosidicus giga) Mantle Protein with a Mixtures of Potato and Corn Starch in an Extruded Snack, as Characterized by FTIR and DSC
Authors:   Centro de Investigación en Alimentación y Desarrollo, A.C. Unidad Culiacán, Culiacán 80110, Mexico, Dolores Muy-Rangel María , Ángel Mazorra-Manzano Miguel , Ángel López-Valenzuela Jose , Lizardi Mendoza Jaime , Mendoza Lizardi , Gutiérrez-Dorado Roberto , Pacheco-Aguilar Ramón , Luis Valenzuela-Lagarda José
Published: May 2022

The majority of snacks expanded by extrusion (SEE) are made with vegetable sources, to improve their nutritional content; it has been proposed to incorporate squid (Dosidicus gigas), due to its high protein content, low price and high availability. However, the interaction of proteins of animal origin with starch during extrusion causes negative effects on the sensory properties of SEE, so it is necessary to know the type of protein–carbohydrate interactions and their effect on these properties. The objective of this research was to study the interaction of proteins and carbohydrates of SEE elaborated with squid mantle, potato and corn. The nutritional composition and protein digestibility were evaluated, Fourier transform infrared (FTIR) and Differential Scanning Calorimetry (DSC) were used to study the formation of protein–starch complexes and the possible regions responsible for their interactions. The SEE had a high protein content (40–85%) and biological value (>93%). The melting temperature (Tm) was found between 145 and 225 ◦C; the Tm values in extruded samples are directly proportional to the squid content. The extrusion process reduced the amine groups I and II responsible for the protein–protein interaction and increased the O-glucosidic bonds, so these bonds could be responsible for the protein–carbohydrate interactions.
Efficacy of Phloroglucinol Tamsulosin Combination Therapy for Medical Expulsion of Lower Ureteral Calculi and Influence on Patients’ Cys-C Level
Authors:   The First Affiliated Hospital of Jinan University, Guangzhou, China, Wu Ying , Chen Guo , Pan Bin , Li Yutong
Published: May 2022

Objective: Phloroglucinol is a myotropic, non-atropine and non-papaverine smooth muscle antispasmodic which directly acts on the smooth muscles of the gastrointestinal tract and the urogenital tract with no anticholinergic effect, no symptoms like xerostomia, visual impairment, dysuria, hypotension, increased heart rate, and arrhythmia etc. To investigate the efficacy of phloroglucinol tamsulosin combination therapy for medical expulsion of lower ureteral calculi and influence on patients’ Cys-C level. Methods: Equally randomized 136 patients with lower ureteral calculi in our hospital into mono therapy group (phloroglucinol alone) and combination therapy group (additional tamsulosin was advised). The expulsion rate, expulsion time, stone diameter and levels of IL-10, CRP, NGAL, Cys-C, KIM-1 were compared between two groups, also with the effectiveness and the rate of adverse reactions. Results: The combination therapy group showed higher expulsion rate (P<0.05) and shorter expulsion time (P<0.05) than that of the mono therapy group and the stone diameter was slightly larger as well (P<0.05). Also, patients under combination treatment had elevated IL-10, CRP, NGAL, Cys-C and KIM-1 levels and a better overall response rate (P<0.05) while it was associated with a slightly higher rate of adverse reactions (P>0.05). Conclusions: Phloroglucinol tamsulosin combination therapy had clear advantages on medical expulsion of lower ureteral calculi in respect of higher expulsion rate and elevated IL-10, CRP, NGAL, Cys-C and KIM-1 levels with larger stone diameter in a shorter time.
The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis
Authors: Diwas Sunchuri , Zhan Pin-Xin , Wang Zheng-Rou , Zheng Hai-Long , Chen Xiang-Qiong Chen , Wu Lin-Han , Lin Wan-Yun , Guo Zhu-Ling
Published: May 2022

Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation
The Counter-Terrorism Committee Executive Directorate and International Humanitarian Law: Preliminary Considerations for States
Authors: Lewis Dustin , Modirzadeh Naz , Burniske Jessics
Published: May 2022

In developing international humanitarian law (IHL), States have aimed in part to lay down the primary normative and operational framework pertaining to principled humanitarian action in situations of armed conflict. The possibility that certain counterterrorism measures may be instituted in a manner that intentionally or unintentionally impedes such action has been recognized by an increasingly wide array of States and entities, including the United Nations Security Council and the U.N. Secretary-General. At least two aspects of the contemporary international discourse on intersections between principled humanitarian action and counterterrorism measures warrant more sustained attention. The first concerns who is, and who ought to be, in a position to authentically and authoritatively interpret and apply IHL in this area. The second concerns the relationships between IHL and other possibly relevant regulatory frameworks, including counterterrorism mandates flowing from decisions of the U.N. Security Council. Partly in relation to those two axes of the broader international discourse, a debate has emerged regarding whether the U.N. Security Council may authorize one particular counterterrorism entity — namely, the Counter-Terrorism Committee Executive Directorate (CTED) — to interpret and assess compliance with IHL pertaining to humanitarian action in relation to certain counterterrorism contexts. In a new legal briefing for the Harvard Law School Program on International Law and Armed Conflict (HLS PILAC), Dustin A. Lewis, Naz K. Modirzadeh, and Jessica S. Burniske seek to help inform that debate by raising some preliminary considerations regarding that possibility. The authors focus on the possible implications of States and other relevant actors pursuing various responses or not responding to this debate. One of the authors’ goals is to help raise awareness of this area with a focus on perspectives drawn from international law. Another is to invite a broader engagement with the question of the preservation of the humanitarian commitments laid down in IHL in a period marked by a growing number — and a deepening — of the intersections between situations of armed conflict and measures to suppress terrorism.
On Another Possible Function of Bucraniums in Ritual Practices of the Cultures of the Pre-Pottery Neolithic of Western Asia
Authors:   National Research University Higher School of Economics, School of History, Zintchenko Sophia
Published: May 2022

The analysis of bucranium found in the settlements of the Pre-Ceramic Neolithic of the Western Asia showed the following: the finds today can be fairly accurately identified by species and sex and dated within the span from the last centuries of the 11th millennium BC to 7600—6000 BC. The study of the context of the use of Bos Primigenius skulls/bones in rooms and with a certain set of accompanying osteological material confirmed the assumptions made by domestic and foreign researchers that bucranium and their individual parts can be considered as a way of presenting not only important symbols, but also individual ceremonies. Reconstructions of the symbolic content of the bucranium presented in literature do not address the question of how it was translated in practice in the process of ritual actions. It is, therefore, relevant to assume that bucraniums could have another possible (practical) function: they could be used as masks. Some important evidence of the working hypothesis is offered by the finds from Cyprus — headforms made from the skulls of bulls and plastic arts used in cult with the image of anthropomorphic figures wearing a similar type of mask. The treatment of bucranium as masks suggests how the object’s meaning is translated through its direct practical application in ritual actions, with symbolic and practical functions complementing each other.
Pengaruh Penyuluhan Kesehatan Tentang Posyandu Terhadap Pengetahuan Ibu Balita di Wilayah Kerja Puskesmas Lubuk Durian Kecamatan Kerkap Bengkulu Utara
Authors: Elsi Rahmadani  , Marlin Sutrisna
Published: May 2022

Integrated service center is one of the government programs related to basic services related to health efforts in preventing infant and under-five mortality. The purpose of this study was to determine the effect of health education on Posyandu on the knowledge of mothers under five in the working area of ​​the Lubuk Durian Health Center, Kerkap District, North Bengkulu. The method used is an analytical research design with a pre and post one group Quasi Experiment approach. The sample in this study amounted to 23 mothers who have toddlers at the Lubuk Durian Argamakmur Health Center. This study uses SPSS with Wilcoxon bivariate statistical test with a value of = <0.05. The results of the univariate analysis showed that the average value of knowledge about posyandu before the Posyandu counseling was 5.30 with a standard deviation of 2.032 and the average value of knowledge after health education about posyandu was 12.87 with a standard deviation of 2.16. The results of the bivariate analysis showed that there was an effect of Health Counseling on Posyandu on Mother Toddler Knowledge in the Working Area of ​​the Lubuk Durian Health Center, Kerkap District, North Bengkulu. The conclusion is that there is an effect of Health Counseling on Posyandu on Mother Toddler Knowledge in the Work Area of ​​the Lubuk Durian Health Center, Kerkap District, North Bengkulu. Researchers suggest that puskesmas are expected to provide information about health, especially about Posyandu for toddlers in the Lubuk Durian Argamakmur Health Center Work Area.
Implementasi Algoritma K-Medoids dalam Pengelompokan Mahasiswa yang Layak Mendapat Bantuan Uang Kuliah Tunggal
Authors: Purba Rohan Kristini , Bu'ulolo Efori
Published: May 2022

The Single Tuition Assistance Program (UKT) is a program aimed at students whose parents' jobs have been affected by COVID-19. Where this assistance is a program from the government to reduce the number of students who stop continuing their education due to the impact of income during Covid-19, so that universities are appointed by the government to select students who deserve the assistance. However, the problem is, the manual selection system can cause errors or confusion in making the selection so that the term wrong target arises. To narrow this possibility, these problems can be overcome by using data mining to assist universities in determining students who deserve single tuition assistance (UKT). In data mining, a method is needed. In this research, clustering method is used using the K-Medoids Algorithm so that decision making is very effective and fast. Based on this research, it is known that those who deserve to receive tuition assistance in arrears (UKT) are Rohan Purba, Zaza Mutiara, Putri and Alexander.
Penerapan Hand Hygiene Petugas di Ruang Perawatan Stroke
Authors: Resmi Dinanti  , Mira Suryani  , Lilik Pranata  , Bangun Dwi Hardika  , M. K. Fitriani Fruitasari
Published: May 2022

Hand hygiene is one of the breakers of the chain of disease transmission in hospitals, so hand hygiene is very important in room management, especially if it is carried out correctly by officers, especially in special rooms where there are patients who are bedres or partial care to total care such as in stroke care. The purpose of the study was to photograph the Application of Hand Hygiene Officers in the Stroke Treatment Room. The research method is descriptive quantitative research design to see the description of the application of hand hygiene. The sample is an officer who provides services in the stroke care room, the study was conducted in a private hospital in Palembang City, primary data collection was carried out on November 1-03 2021, with a sample of 18 people, the instrument used was an observation sheet, and the sample criteria were in accordance with with the inclusion criteria of officers on duty in the stroke care room. The results showed that there were still officers who had not applied the five moments and 6 steps of washing hands properly. Suggestions for hospital institutions gave policies to room staff in getting used to doing hand hygiene. Meanwhile, health workers must realize the importance of hand hygiene for the patient's recovery process and improve hospital services.
Model Penilaiann Kinerja Karyawan dengan Personal Balanced Scorecard
Authors: Nur Aziz  , Dewanto Ignatius Joko
Published: May 2022

Employee performance is assessed through superiors, subordinates and co-workers. Work performance or employee performance can later be used to determine employee policies in improving their performance in the future. The Personal Balanced Scorecard (PBSC) describes employees in four areas, namely: internal, external, skills and learning, and finance. By applying this method can help the managerial for the purposes of assessing its employees objectively.
CYSTIC FIBROSIS SCENARIO IN INDIA
Authors: Patel Chitra , Marathe Bhavna , Jadav Priyanka , Acharya Dhaval , Gohel Hardik
Published: May 2022

Abnormal transport of chloride ion in the epithelial cells is caused by a autosomal recessive monogenic condition known as cystic fibrosis (CF). It belongs to the rare genetic disease in India. Persistent coughing with phlegm, pneumonia, bronchitis, bulky stool and hard bowl movement are most symptoms of the disease. Mutation in CFTR (cystic fibrosis transmembrane conductance regulator) gene present on chromosome 7 having 230 kb nucleotides with 23 exons leads to development of disease. Determination of sweat electrolyte is considered as optimal diagnostic method. Results of previous studies have shown that cystic fibrosis increase the sodium and chloride concentrations. Mutations like ΔF508, G542X, R553X, N130K and 621+1 (G →T) are most common in CF patients in India. Among them ΔF508 is most severe and predominant mutation. Reports have shown as high as 56% frequency of ΔF508 in Indian patients. CF can be treated with anti-inflammatory drugs, CFTR modulators and combination therapies. Early screening can be an effective strategy for early diagnosis and treatment of cystic fibrosis.
NEUROFIBROMATOSIS: A CAUSE OF CONCERN
Authors: Vishwanathan Ramya , Gupta Vinod Kumar
Published: May 2022

Neurofibromatosis (NF) is a rare genetic disease which causes tumors to grow on the nerve tissues. These being noncancerous and less life threatening, patients affected with NF can lead a normal life if the cosmetic issues are ignored. Although there are treatments available like surgeries or use of FDA approved drugs that can control the progression and symptoms in people affected with this disorder, researchers are still trying to find a potent solution that can permanently curb this disease. Novel technologies such as stem cell technology and CRISPR genome editing are being studied that could act as a cheaper, reliable, noncomplex and less time-consuming solution to this rare condition. In the current scenario, COVID-19 affected NF patients have neither shown progression of the NF condition or any severe side effects after being administered with vaccines. This review gives a gist of the drugs which are currently in use for treatment of this disease and various signaling pathways involved in the activation of Neurofibromatosis that could be inhibited using computational methods in the near future so as to obtain a solution which can be employed in the early stages itself.
SYNTHESIS AND ANTIBACTERIAL EVALUATION OF 3-ARYL INDAZOLES
Authors: Kola A Emmanuel , Kumar P Hemanth , Satish V A N , Boddapati S N Murthy
Published: May 2022

A series of 3-aryl indazoles 4a-4j were obtained by Pd catalyzed Suzuki coupling reaction. All the substrates were obtained in good yields under moderate reaction conditions. Next, the prepared compounds 4a-4j were screened for
their antibacterial activity. The anti-bacterial activities of the prepared compounds were investigated against three
bacterial strains i.e. Xanthomonas campestris, Escherichia coli, Bacillus megaterium. The anti-bacterial evaluation studies of
these 3-aryl indazoles revealed that some of these test compounds possess moderate in vitro antibacterial activity.
APPLICATION OF RESPONSE SURFACE METHODOLOGY (RSM) TO ENHANCE MCLPHA COPOLYMER PRODUCTION BY MASSILIA SP USING CANE MOLASSES AS A CARBON SOURCE
Authors: Naik Priyanka , Ranade Vaijayanti
Published: May 2022

Cane molasses is an inexpensive, sustainable by-product of the sugar industry, which supports the growth of
microorganisms as it contains several growth factors. Response Surface Methodology (RSM) employing central
composite design (CCD) was applied to enhance PHA production by Massilia sp at shake flask level by using molasses as a
carbon source. Isolate produced maximum DCW (54.0 g/l) and PHA (3.0 g/l) when medium was optimized with the
help of CCD. Optimized concentration of medium components to maximize PHA production was found to be as
follows: molasses: 100.0 g/l, NH4HPO4
: 1.67g/l, Na2HPO4
: 5.86g/l, K2HPO4
: 5.74g/l, MgSO4
: 0.25g/l, trace
element solution: 0.1ml/l. The point optimization method reported a small difference of 0.02g/l, indicating the validity
of mathematical models developed after applying CCD.
PRODUCTION AND APPLICATION OF LACCASE IN BIOTRANSFORMATION OF LIGNOCELLULOSIC MATERIAL AND DECOLOURIZATION OF DYES
Authors: Karegoudar T B , Vijayakumar M H
Published: May 2022

Cladosporium cladosporiodes is a novel strain isolated and evaluated for the production of laccase in submerged
fermentation. Objective of present work was to optimize the laccase production and assessment of delignification in
wheat bran by laccase of Cladosporium cladosporiodes in submerged fermentation. The significant laccase production was
observed in Byred’s medium when grown on wheat bran at static condition. The optimum conditions i.e. pH 5.6,
temperature 40°C, wheat bran 4g, CuSO4
concentration 0.1mM were required for laccase production in submerged
fermentation and there was no any role of tested six aromatic inducers on laccase production. The extracellular laccase
enzyme of Cladosporium cladosporiodes produced from lignocellulosic material fermentation involved in delignification of
wheat bran, biotransformation of lignin model compounds and decolourization eight different azo, metal complex and
triphenyl methane dyes.
IOT Based Evaluation of Internal Fault Detection In Transformer Using V-I Characteristics
Authors: V S Roshini , V Ramanujam , V Udhaya , R Karthik
Published: May 2022

The common problem in operating the power transformer is the winding deformation due to the internal and external conditions. It should be controlled and rectified soon as it emerge, as it is progressive in nature. Unfavorably,theonlytechniquetodetect and identifysuchfaultsatthis stage is the frequency response analysis technique which is conducted offline. In this paper, we are proposing an idea to detect power transformer incipient winding deformations in real time by measuring voltage and current level in transformer in online mode. In this method, we are monitoring the live status of transformer using cost efficient and easily available sensors.
The Impact of the COVID-19 Pandemic and Transition to Distance Learning on University Faculty in the United States
Authors: Brandau Melvina , Vogt Marjorie , Garey Mary Lou
Published: May 2022

Background: The unexpected COVID-19 pandemic impacted not only students at institutions of higher learning, but also faculty who often made rapid transitions from face-to-face to online or distance learning. Distance learning has been shown to negatively impact college students’ physical activity, screen time, and mental health concerns. Little is known, however, about the transition and impact of the pandemic and distance learning on university faculty. Purpose: The purpose of this study was to examine the impact of the rapid transition from traditional face-to-face teaching methodologies to distance learning on professional quality of life, physical activity, screen time, and anxiety and depression among faculty. Methods: A descriptive survey design with snowball sampling, was used to collect data anonymously, online. An electronic survey was developed to explore professional quality of life, physical activity, screen time, anxiety, and depression. Results: The COVID-19 pandemic and subsequent rapid transition of teaching and learning methodologies impacted not only students, but faculty at institutions of higher learning. Most faculty indicated concerns with their professional quality of life, putting them at moderate risk of burnout. A negative correlation between leisure time and anxiety or depression was found as well as a positive correlation between increased screen time and depression. Conclusion: Increased screen time and decreased physical activity or leisure time may contribute to increased faculty burnout, depression, and anxiety. University administration may need to consider strategies to help faculty cope with transitions to unfamiliar teaching methodologies and self-care behavioral changes to avoid faculty dissatisfaction and disengagement.
The Organisation of Social Reproduction in a Postcapitalist Participatory Economy
Authors: Chowdhury Savvina
Published: May 2022

mέta Working Papers’ series “Towards (a Better) Postcapitalism: A Handy How-To Guide” publishes solicited policy papers on aspects of how would a non-dystopian postcapitalism look like. The series focuses on three ‘pillars’: Production | Allocation | Decision Making i.e., how could/would postcapitalist production be like (and who would own the means of production), what shape would the allocation of goods take (and which alternatives to the market economy may be explored), and what would be the main tenets of postcapitalist decision making and democracy. In this paper, Savvina Chowdhury addresses the first pillar, i.e. producion.
KAJIAN TEOLOGIS PELAYANAN TUHAN YESUS BERDASARKAN MATIUS 4:23-25 DAN IMPLEMENTASINYA BAGI PELAYANAN GURU PAK DALAM MEMBERITAKAN INJIL KEPADA SISWA SD
Authors: M.Th Rita , M.Th Vinus Zai
Published: May 2022

Masa Pelayanan Tuhan Yesus di dalam dunia sangat singkat, yaitu sekitar tiga setengah tahun, tetapi dampaknya sangat luar biasa mempengaruhi hidup seluruh umat manusia di sepanjang sejarah. Di dalam pelayanan-Nya, Tuhan Yesus disebut sebagai Tuhan dan guru tidak hanya oleh murid-murid-Nya, tetapi juga oleh musuh-musuh-Nya. Tuhan Yesus bukan seorang guru biasa, IA adalah guru Agung karena IA tidak hanya mengajar melalui perkataan saja, tetapi IA melakukan apa yang dikatakan-Nya untuk menjadi teladan bagi murid-murid-Nya. Hal ini sangat menarik untuk diketahui oleh Guru Pendidikan Agama Kristen agar dapat mengajar murid-murid yang Tuhan percayakan dengan prinsip yang benar sehingga tepat sasaran dan efektif. Oleh karena itu untuk mengetahui prinsip Pelayanan Tuhan Yesus dalam Matius 4:23-25 dilakukan penelitian  dengan metode kualitatif deskriptif analisis, yaitu melalui eksegese Matius 4:23-25. Proses analisis ini menghasilkan beberapa temuan, yaitu: Pelayanan Tuhan Yesus merupakan pelayanan holistic yang  dimulai oleh Allah, berdasarkan kasih Allah kepada manusia dan disertai oleh kuasa Allah untuk memberikan keselamatan kepada manusia seutuhnya. Temuan ini dapat diimplementasikan kepada Guru Pendidikan Agama Kristen (PAK) sehingga dapat menggenapi panggilan Tuhan dengan sukacita dan berpengharapan.
Pengaruh Stres Mahasiswa Teologi Terhadap Pengenalan Akan Allah Menurut 2 Petrus 1:1-2 di Sekolah Tinggi Teologi Imanuel Pacet
Authors: Kadarsi Naumi
Published: May 2022

Mahasiswa mengalami tekanan akademik karena adanya tuntutan yang harus dijalani diantaranya bersosialisasi dan menyesuaikan diri dengan melakukan kegiatan baik akademik maupun non akademik. Mahasiswa teologi merupakan orang-orang yang terpanggil dan terpilih untuk memfokuskan hidupnya meresponi panggilan Tuhan. Pembelajaran utamanya dalam sekolah tinggi teologi adalah Alkitab atau Firman Tuhan dan kehidupan berasrama berlandaskan Firman Tuhan.Kategori stress yang dihadapi oleh mahasiswa termasuk dalam daily hassles. Daily hassle adalah jenis stressor yang membutuhkan sedikit penyesuaian sepanjang hari atau setiap hari oleh yang bersangkutan. Kasih karunia dan kedamaian tidak dapat ditemukan di luar "Pengetahuan penuh" (ἐπίγνωσις) dapat dianggap sebagai catatan kunci dari Surat 2 Petrus, karena kata (ἐπίγνωσις) atau pengetahuan penuh yang lebih kuat dari istilah pengetahuan atau gnosis γνωσις.Apakah mahasiswa STT Imanuel Pacet yang sehariannya belajar tentang Teologi, pengelanannya akan Tuhan dipengaruhi oleh stres sebagai mahasiswa? Dari hasil penelitian kuantitaif dan kualitatif didapat mahasiswa mengalami stress karena beberapa hal dan hal tersebut mempengaruhi pengenalannya akan Tuhan karena memberi dampak terhadap fisik, pikiran, emosi maupun tingkah lakunya. Padahal 2 Petrus 1:1-2 memberikan pembahasan iman yang diperoleh karena keadilan Allah melimpahi kasih karunia dan damai sejahtera oleh pengenalan akan Allah dan akan Yesus Tuhan.
Inner Peace in Islam
Authors: Keskin Zuleyha
Published: May 2022

The notion that Islam means peace has almost become a cliché in a world where Islam’s relationship with peace is emphasised in an attempt to reclaim it from any association with terrorism. Islam does mean peace. Not only does Islam mean peace, but it also has a strong affiliation with inner peace through the tranquillity and peace it offers as a result of internalising the Islamic faith.

Despite this strong affiliation with inner peace, there is minimal contemporary English literature regarding the relationship between Islam and inner peace. This is not because there is no connection between the two, but rather, it is a matter of language and conceptualisation. Most of the Islamic literature related to inner peace is encompassed within tasawwuf (Islamic spirituality) and extensively discussed in Arabic, Persian and Turkish. On the other hand, contemporary English literature on inner peace is predominantly from a Buddhist perspective, but also includes Hindu, Christian, Jewish and non-religious perspectives.

When tasawwuf is delved into, various Islamic concepts can be identified that have a strong association with inner peace. The three concepts that will be analysed in this paper are riḍā (contentment), sakīna (serenity) and itṃ īnān (peace). These concepts can be brought together to produce a definition of inner peace that is true to the Islamic tradition: inner peace is attained when life and events are given a tawhị̄d-centric meaning in a way that satisfies the heart and mind.
Religiosity, Attitudes on Diversity and Belonging Among Ordinary Australian Muslims
Authors: Atie Rosalie , Dunn Kevin , Ozalp Mehmet
Published: May 2022

Islamic incompatibility is a core discourse of fringe political parties, mostly from the right of the political spectrum, who have agitated against religious diversity and also against immigration of Muslims, especially from certain parts of the world. Smaller scale political alliances, against mosque developments, private Islamic schools or halal certification, also draw heavily on this pre-supposition. Despite the preponderance of such despondent commentary, there is surprisingly little by way of empirical analysis of this assumption of incompatibility. This paper draws on a community survey (n:585) and the results show high rates intercultural mixing in workplaces, educational settings and socially, with little evidence for separatism. These Australian Muslims have very positive views about cultural diversity, most perceive there to be consistency between Islam and Australian norms, and they see themselves as Australian. Those with stronger levels of religiosity have even more positive views on diversity and consistency. We offer two explanations, one based on official multiculturalism, and the other on tenets of Islamic thinking on toleration and moderation.
Muslims in the Military
Authors: Wessell Luke
Published: May 2022

Australian Muslims rarely join the Australian Defence Force. There is no evidence this statistic is changing, no sign it is likely to change in the near future, and meanwhile the Australian Muslim population continues to grow faster than the general Australian population. If statistical trends continue, at best the situation will become far more noticeable, and at worst it will become an issue of national security and societal cohesion. This paper discusses the risks of long-term segregation of Australian Muslims from the nation’s defence forces, and considers them alongside the risks of acting to deliberately increase in numbers of Muslims serving in the ADF. Muslim jurists face a dilemma, where the scholar who is against Islamic service in the ADF risks being perceived as not supportive of Australia’s efforts to fight ISIS, et al, and the scholar who comes out in support of ADF service risks being perceived by their own community as endorsing Western imperialism and the collateral damage suffered by innocent Muslims in the same geographical areas. Similar dilemmas for ADF leadership also exist and are the cause of app
Reasoning with God: Reclaiming Shari'ah in the Modern Age by Khaled Abou El Fadl
Authors: Sultan Ramia
Published: May 2022

Abou El Fadl, Khaled. Reasoning with God: Reclaiming Shari’ah in the Modern Age. US, Rowman & Littlefield Publishers: 2014. pp. 556. $53.00. 978-0-7425-5232-6.
Are Faith Based Programs Effective in Reducing Recidivism?
Authors: Yucel Salih , Paget John
Published: May 2022

Although Muslims comprise 5.3% of the NSW population, they account for 9.3% of prisoners in correctional centres. The high rate of Muslim representation in the prison population is the result of longterm neglect of the needs of second and third generation of Muslims by the wider Muslim community and by governments. This article first argues the high rate of the Muslim population in the prisons is not a failure of Muslim community alone, but is a product of a combination of individual, familial and societal failures due to various factors. These factors are multidimensional and need to be identified accurately to fashion appropriate responses. This article proposes a strategy for reintegration of Muslim parolees into society and reducing recidivism in prisons based on the experiences from a parolees mentoring program, which was conducted in 2016 by a community based institution, Islamic Science and Research Academy of Australia (ISRA), in collaboration with Bankstown Community Corrections Centre (a department of NSW Corrective Services). The findings show a mutual collaboration between NSW Corrective Services and faith-based organisations can assist in reducing recidivism in Muslim parolees.