bluuebunny/crossref_metadata_2025 huggingface dataset:
BACTERIOLOGICAL PROFILE OF PATIENTS WITH SEPSIS ADMITTED IN INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL OF RAWALPINDI
Authors: Haroon Muhammad , Ajmal Fahad , Gul Aisha , Khan Muhammad Saeed , Khan Jawad
Published: July 2023

Objectives: To determine bacteriological profi le of patients with clinical signs of sepsis admittedin Intensive care unit of a tertiary care hospital.Materials and Methods: A cross-sectional study was conducted among 220 patients having sepsisand admitted in intensive care unit of Bahria International Hospital Rawalpindi from November2021 to October 2022. Various clinical specimens including blood, urine, central venous cathetertip, and Foley catheter tip were collected from target subjects and immediately transported toPathology laboratory for microbiological analysis.Results: Out of total 220 patients,our data showed that 140 (63.6%) were male while 80 (36.4%)were female subjects with mean age of 41.623±6.782. Patients were recorded with various illnessesincluding Diabetes Mellitus (56.8%), Hypertension (25%), Asthma illness (24.5%) and end stagerenal disease (26.8%). Least cases were observed for Stroke (29.1%), Malignancy (5.4%) and otherdiseases (3.6%). Urine sample was sent for 170 (77.2%) patients while blood cultures were sentfor 110 (50%) patients. Bacteriological profi le of samples revealed that 168 (76.3%) were Gramnegative bacteria while 52 (23.7%) were Gram positive bacteria. The prevalent Gram negativebacteria was recorded as Escherichia coli45.9% (n=101) followed by Pseudomonas aeruginosa14.8% (n=25). Among the Gram bacteria, methicillin resistant Staphalococcus aureus(n=41,78.8%) was most frequent followed methicillin sensitive Staphalococcus aureus (n=8, 15.3%).
Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report
Authors: Midaglia Luciana , Felipe-Rucián Ana , Delgado Alvarez Ignacio , Montalban Xavier , Tintoré Mar
Published: July 2023

The clinical-radiological and biological overlap of the spectrum of pediatric demyelinating disorders makes the diagnostic process of a child with an acquired demyelinating syndrome truly challenging. We present a 9-year-old girl with subacute symptoms of severe decrease in bilateral visual acuity and gait ataxia. An urgent MRI showed inflammatory-demyelinating lesions affecting the periaqueductal gray matter, the cerebellar hemispheres, the area postrema as well as both optic nerves and chiasm. Likewise, multisegmental involvement of the cervical and dorsal spinal cord was found, with short and peripheral lesions. Anti myelin oligodendrocyte glycoprotein (MOG) antibodies (Abs) were positive in cerebrospinal fluid (CSF) and weakly in serum. Oligoclonal bands (OB) were positive in CSF. Based on all this, the diagnosis of MOG antibody disease (MOGAD) with a neuromyelitis optica spectrum disorder (NMOSD)-like picture was made. Given the good clinical and radiological recovery after the acute phase treatment, and that anti MOG Abs became negative, it was decided to keep the patient without specific treatment. However, during follow-up, while the patient was asymptomatic, a control brain MRI showed the appearance of new lesions with morphology and topography suggestive of multiple sclerosis (MS). This, added to the presence of OB, made the diagnosis of pediatric-onset MS (POMS) likely. Immunosuppressive treatment was restarted with a good response since then. Unlike adult-onset MS, children with POMS may usually not have entirely typical clinical and radiological features at presentation. In many cases, the time factor and close clinical and radiological monitoring could be critical to make an accurate diagnosis.
Avaliação da lombalgia, comprimento muscular e alterações na lordose lombar em corredores
Authors: Vendramini Marchetti Barbara , Lima Selau Bruna , Da Silva Medeiros Fernanda , Tarragô Candotti Claudia
Published: July 2023

O objetivo do estudo foi verificar a relação entre tempo de prática da corrida de rua com a lombalgia, o encurtamento muscular e a postura da coluna lombar, e identificar se o tempo de prática influencia a postura da coluna lombar, o comprimento muscular de músculos extensores do quadril e da cadeia posterior. Trinta corredores de rua com idades entre 18 a 80 anos, divididos em três grupos (iniciantes, intermediários e avançados), foram avaliados quanto: à presença de lombalgia – a partir de um questionário; ao comprimento muscular de isquiotibiais – a partir da mensuração da amplitude de movimento (ADM) da flexão do quadril; ao comprimento muscular da cadeia posterior - mensuração da distância entre os dedos da mão e o solo; e ao ângulo da lordose lombar – utilizando o instrumento flexicurva. Os dados foram analisados por ANOVA one-way e pelo teste de correlação de Spearman (a<0,05). Não houve correlação entre queixa de dor e comprimento de isquiotibiais, comprimento da cadeia posterior e ângulo da lordose lombar. Foi encontrada correlação significativa entre comprimento de isquiotibiais e comprimento da cadeia posterior somente para o grupo intermediário. A literatura não apresenta consenso quanto à relação entre flexibilidade de isquiotibiais e lombalgia, bem como entre a queixa de dor lombar e o ângulo da coluna lombar, da mesma forma que o atual estudo. Verificamos que a prática da corrida não teve influência na dor e nos encurtamentos musculares, independentemente do tempo de prática.
COMPETENCY IMPROVEMENT EFFORTS STUDENTS OF SMKN 1 PULANG PISAU WITH AUTOCAD LEARNING ASSISTANCE
Authors: Ni Putu Diah Agustin Permanasuri  , Tarita Aprilani Sitinjak  , Tamara Apriliayana  , Eko Wicaksono  , Apriansyah
Published: July 2023

This community service aims to provide insight into knowledge and skills about technological developments in software engineering design in the field of engineering drawing design. Through this activity, it is expected that SMKN 1 Pulang Pisau students can know, and practice directly using Autocad applications in drawing and can improve students abilities, understand technological developments, and can apply them in making drawings of building components in two-dimensional form using the Autocad application. The service targets students majoring in Construction and Property Business (BKP) at SMKN1 Pulang Pisau. The problem that occurs is that students still use the manual method in drawing techniques, and students are not familiar with the Autocad application. Implementation is carried out with assistance in the form of Autocad learning training using presentation, practice, and discussion methods, as well as providing modules to students, with the hope that students will understand and be able to practice using Autocad applications to draw independently
OPTIMIZATION OF SURGICAL TREATMENT OF PATIENTS WITH RECTUS ABDOMINIS DIASTASIS
Authors: Gaft K. L. , Tsiliurik V. V.
Published: July 2023

Summary. Introduction. The experience of treating 88 patients with rectus abdominis diastasis and rectus abdominis diastasis in combination with anterior abdominal wall hernias is presented. The effectiveness of various types of laparoscopic and traditional surgical interventions have been studied.

Aim. Optimization of surgical treatment of patients with rectus abdominis diastasis by developing and implementing new various types of laparoscopic interventions.

Materials and methods. All 88 patients were divided into 2 groups. The main group consisted of 43 patients (26 women and 17 men), the comparison group – 45 (19 men and 26 women). In the comparison group, patients underwent surgical interventions using traditional methods: autoplasty according to Sapezhko – 2; Autoplasty according to Napalkov – 10; Alloplasty according to the “inlay” type – 23; Allogernioplasty according to the “Subllay” type – 10. In the main group, patients underwent surgical interventions using purely laparoscopic methods in the volume: rectomuscularography according to the “Total Endoclose” type – 7; operation “ Irom “with fixation of the prosthesis according to the type” Total Ergoclose” – 20; operation “Irom “+ rectomuscularography with fixation of the prosthesis according to the type “Total Ergoclose” – 13; operation “E-TEP”according to the river-Stoppa method with fixation of the prosthesis according to the type” Total Ergoclose” – 1.

Research results and their discussion. The effectiveness of operations was evaluated basing on the quality and rate of formation of muscle duplication, or reticular-fibrous complex on the site of diastasis, by measuring the thickness of the anterior abdominal wall using ultrasound at three levels: in the epigastric zone – approximately 7 cm. above the navel, or along the upper edge of the mesh graft fixation; 2 cm above the navel, or along the conditional center of the mesh graft; 2 cm below the navel, or along the lower edge of the mesh graft fixation. Studies in each zone were performed three times: on the 5th day, 1 month later, and 6 months after surgery.

Conclusions. The formation of a mesh-fibrous complex, or muscle duplication, during open operations lasts much longer than during laparoscopic interventions. In the main group, a month later, ultrasound data shows almost complete restoration of the natural anatomy of the abdominal wall, and 6 months after surgery, the difference between the thickness of the anterior abdominal wall in the main group and the comparison group is 3 times.
Incidencia y prevalencia de infección intraoperatoria en la cirugía urológica
Authors: Peralta Farak Juan Carlos , Contreras Castro Andrea Carolina , Chadid Silgado Mario Alberto , Salguero Sánchez Jefferson Augusto , Esquivel Monterroza Jean Carlos , Acevedo Martínez Ricardo José , Romo Córdoba Franklin Alexander , Velásquez Molina Diego David , Ruales Benavides Nataly
Published: July 2023

La infección del sitio quirúrgico (ISQ) es un hecho que afecta la estancia hospitalaria de los pacientes, teniendo esta su mayor relación con la falta de asepsia en los sitios de operación. Sin embargo, no se descartan otros factores de riesgo que se relacionan con esto como pueden ser la edad , comorbilidades, la técnica quirúrgica, etc. En la cirugía urológica, los procedimientos quirúrgicos con el mayor índice de tasa de ISQ que se mencionan son la colecistectomía radical, adenomectomia y biopsia transrectal de próstata. En el siguiente artículo de revisión nos enfocamos en la búsqueda de artículos científicos en diferentes revistas nacionales e internacionales especializados en el tema, destacando reportes de casos en los se muestra la incidencia y prevalencia de la infección del sitio quirúrgico en las diferentes técnicas quirúrgicas realizadas a los pacientes siendo estos reflejados en los resultados. De modo que, la prevención de las infecciones del sitio quirúrgico en cirugías urológicas requieren de una gran atención con enfoque integral, con el fin de la reducción de la incidencia y prevalencia de estas infecciones.
LGBTIQ+ Inclusive Education
Authors: López-Medina Esteban Francisco
Published: July 2023

The 21st-century digital society has brought with it an overflow of information which makes it more urgent than ever to develop critical skills and the ability to think for oneself. The theories of education have stressed this need for long, but the recent, emerging inclusion of LGBTIQ+ people in formal lessons, even if frequently contested by some, may be a timely opportunity for teachers to help their students develop criticality. This chapter delves into all these issues to carry out an argumentative literature review whose aim is to show the potential that the critical inclusion of LGBTIQ+ experiences in education has for the sake of promoting both teachers' and learners' critical thinking skills. This initial understanding of the diversity inherent to sexes, genders, and identities, it is argued, can easily prepare them to transfer such competence to the comprehension of other complex human realities.
Contributions of martial arts in Physical Education classes
Authors: Lima George , Pereira Marcos
Published: July 2023

This study aims to reflect, from an integrative review, on the benefits of teaching struggles for the integral development of students of basic education. Data collection was carried out in Scielo, Lilacs, Google Scholar, and Capes Periodicals Portal, using the descriptor: “Benefits AND Fights AND School”. The results show eight studies, in which, based on the analysis, it was clarified that the development of fights in Physical Education classes brings benefits to students, in the development of motor, affective, social, cognitive, and physiological aspects. However, deficits in initial training and the absence of policies that expand the continuing education of teachers are configured as a problem for the implementation of this practice in the school environment, negatively affecting teachers in the adoption of methodological resources for the effective development of struggles at school. It was concluded that the practice of fights in physical education classes, if it is systematized according to the students' sociocultural processes, presents benefits. Therefore, this corporal practice must be effectively inserted in the students' activities. There were also possibilities for teaching fights based on the content dimensions, considering practical, conceptual, and attitudinal processes that involve fights.
The Effect of Capital Structure on Firm Value in Banking Companies Listed on the Indonesia Stock Exchange
Authors: Sonjaya Yaya , Muslim M.
Published: July 2023

This study is to determine the effect of capital structure on firm value in banking companies on the Indonesia Stock Exchange. The data used is quantitative data. The population in this study were 8 banking companies listed on the Indonesia Stock Exchange, while the sample used in this study used the Purposive Sampling formula of 40. Data collection was carried out through documentation. The data analysis method used is the classic assumption test, regression analysis, and hypothesis testing using SPSS 23 for Windows software. Based on the results of research that examines the effect of the Debt-to-Equity Ratio on Price Book Value, the t value = 4.801 is greater than the t table = 2.02439, with a significance level of 0.060 greater when compared to the α = 5% level, then H1 is accepted. The constant value of 3.826 means that, if the DER variable does not change, then PBV has a value of 3.826. Meanwhile, the DER variable coefficient value of -0.262, means that if DER increases by one percent, PBV decreases by 0.262. These results indicate that statistically DER has a negative and insignificant effect on PBV in Banking Companies listed on the Indonesia Stock Exchange. Thus, the hypothesis stating that DER has a negative and insignificant effect on PBV in Banking Companies listed on the Indonesia Stock Exchange is proven.
Tutor no ensino superior a distância
Authors: Gildo Laudicéia Aparecida , Guilherme Cláudia Cristina Fiorio
Published: July 2023

Este trabalho pretende promover a reflexão sobre o papel do tutor no Ensino Superior a distância, que ainda não tem especificações de legislação própria nem delimitações. Sendo assim, o tutor segue orientações e trabalha de acordo com as determinações das instituições de Ensino Superior nas quais atua. A Educação a Distância (EaD) é a responsável por esse novo trabalho docente. Diante disso, questiona-se: será que a figura do professor pode desaparecer? O resultado desse estudo buscou demonstrar as diferenças entre os papéis de professor e tutor. Igualmente importantes, as funções de um professor e de um tutor muitas vezes se misturam e se fundem ao mesmo tempo em que se distanciam, e os meios utilizados no processo de ensino-aprendizagem podem ser uma das diferenças que caracterizam as funções entre um e outro, mas não somente isso. Os dados coletados durante a pesquisa qualitativa realizada para este trabalho demonstram algumas diferenças e algumas semelhanças entre tutor e professor.
A importância do metabolismo anaeróbico no futebol
Authors: Cunha Renato Gheller da , Oliveira João Carlos de
Published: July 2023

O futebol é uma modalidade esportiva intermitente e acíclica, com constantes alternâncias de intensidade e ações. Essas modificações durante uma partida de futebol exigem que o futebolista seja capaz de vencer a resistência e suportar cargas intensas da maneira mais eficiente possível. Várias investigações acerca da capacidade fisiológica e do padrão de atividades do jogador durante uma partida de futebol permitiram constatar que a grande maioria das ações são aeróbias. Dessa forma, pode-se afirmar que o jogador passa a maior parte do jogo em caminhada ou trote de baixa intensidade. Para chegar nesta constatação, essas investigações utilizaram, na maioria das vezes, os seguintes indicadores: limiar anaeróbio (LA), consumo de oxigênio máximo (VO2máx), frequência cardíaca, intensidade de esforço, concentrações de lactato, distância percorrida, duração, número de sprints, intensidade das ações realizadas e relação entre tempo de atividade e pausa. No entanto, essas investigações também demonstram que as ações decisivas em uma partida de futebol, ou seja, aquelas que definem uma disputa de bola ou que, muitas vezes, ajudam a realizar ou evitar um gol são anaeróbias. Sendo assim, o futebolista, dada a demanda variada de intensidade de esforço numa partida, tem de privilegiar no seu treino características tão distintas como o desenvolvimento da força explosiva, da velocidade, da agilidade, da flexibilidade, da resistência aeróbia e anaeróbia, de forma harmônica e conjugada. Dessa maneira, o propósito desta investigação é rastrear a capacidade fisiológica e física dos atletas durante uma partida, e assim demonstrar a importância do metabolismo anaeróbio no futebol.
Os paradigmas culturais e seus impactos na saúde do homem
Authors: Helaehil Luiza Venturini , Ortiz Bruna Tayná Moreira , Dorigan Gisele Hespanho , Milagres Clarice Santana
Published: July 2023

A masculinidade foi formada em um processo histórico patriarcal, em que havia construções hierárquicas que, consequentemente, compuseram a imagem de supremacia refletida sobre o homem. Objetivo: discutir a articulação entre os aspectos culturais e os fatores de risco relacionados a maior morbimortalidade e ações voltadas para a assistência da saúde do homem. Metodologia: Realizou-se uma revisão de literatura nas bases de dados Pubmed, Medline, SciELO, Bireme/LILACS e Science Direct, livros e revistas, por meio de busca nas publicações entre os anos de 2007 e 2017. Resultados: Identificou-se onze artigos, dos quais oito compuseram a amostra desta pesquisa. Constatou-se maior prevalência de fatores como feminilização da saúde, fatores culturais e temor relacionado ao trabalho. Considerações Finais: A relação entre os aspectos culturais e os fatores de risco relacionados a maior morbimortalidade é diversificada e, no geral, há poucas ações voltadas para a assistência da saúde do homem.
Argumenting the need for integrated training of highly qualified rugby referees
Authors: Diaconescu Robert , Bragarenco Nicolae
Published: July 2023

This article highlights the need for a special approach in training the referee who officiates a rugby match. The special approach to the training of the rugby referee is determined by the complexity of the game, which is characterized by the multitude of technical-tactical actions operated by the athlete in the three forms of the game, group-penetrating game, open game and the game with the foot, but also by the existence of moments fixed and the multitude of fixing points characteristic of the game. Knowledge of the rules of the game and physical training of the referee is not enough to direct a rugby match, apply the rules correctly and impartially. The referee must possess a thorough knowledge of the technique and tactics of the game that will allow antici-pation of deviations from the rules. At the same time, it should be mentioned that the training of rugby referees must be produced in a complex form, applying strategies that combine the methods and means of theoretical, physical, technical-tactical and psychological training. This approach, in the specialized literature, is defined as integrated training.
Comparative analysis of reflection, personal maturity and self-actualization in young people with different types of loneliness experience
Authors: Bondarenco Olga
Published: July 2023

he article provides a quantitative and qualitative analysis of the differences in reflection, personal maturity and self-actualization in groups of young people with different types of experiences of loneliness. Groups were formed that reflect all three scales of attitudes towards loneliness. Were studied various forms of reflection, indicators of personal maturity and self-actualization in young people. In this way groups of young people with positive loneliness, with a common experience of loneliness, and dependent on communication - differ in the type of ,,systemic reflection” and ,,quasi-reflection”. Groups of young people with a positive attitude towards loneliness and dependence on communication differ in terms of ,,general personal maturity” and "self-development”. Also, there are differences on the scale of general self-actualization, self-esteem, synergy, creativity, flexibility of behavior and value orientations
Evaluación de niños perinatalmente expuestos al virus de inmunodeficiencia humana en el hospital nacional Arzobispo Loayza durante el periodo 2015-2018
Authors:   , Chauca Blancas Sandra Graciela
Published: July 2023

Objetivo: Evaluar a los niños perinatalmente expuestos al virus de inmunodeficiencia humana en el Hospital Nacional Arzobispo Loayza durante el periodo 2015-2018. Material y métodos: Tipo de estudio es Observacional, Descriptivo, Transversal y Retrospectivo. La población fueron 48 niños perinatalmente expuestos, la técnica de recolección de datos fue una ficha de recolección de datos. Resultados: Al evaluar el estado nutricional al año encontró un peso promedio de 10.200kg lo que según los indicadores de este objetivo demostrarían un buen porcentaje de niños eutróficos. Respecto al desarrollo psicomotor el 35.6% no tenía control, el 58.1% tenía riesgo y/o trastorno en alguna de las áreas evaluadas. En cuanto a las complicaciones perinatales se encontró un 14.6% de bajo peso al nacimiento, prematuridad en 12.5%, mientras que el valor de Apgar no mostro alteraciones. El tipo de profilaxis antirretroviral más usada fue la monoterapia en 72.9%; en relación con los efectos adversos se determinó como único efecto adverso a la anemia en 60.4%. Conclusiones: Los niños perinatalmente expuestos al virus de inmunodeficiencia humana no tuvieron alteraciones en su evaluación nutricional, así mismo se encontró una cifra considerable sin control de desarrollo psicomotor. En relación a las complicaciones perinatales se concluye como la más frecuente al bajo peso al nacimiento, el tipo de profilaxis más usada es la monoterapia; y el único efecto adverso que se encontró en el presente estudio fue la anemia.
Factores asociados a complicaciones infecciosas en trasplante renal del centro médico naval durante enero 2009 a julio 2019
Authors:   , Urrutia Orchard Ricardo Jesús
Published: July 2023

Objetivo: Determinar los factores asociados a complicaciones infecciosas en trasplante renal del Centro Médico Naval durante Enero 2009 a Julio 2019. Métodos y materiales: Se realizó un estudio de tipo analítico, transversal, observacional y retrospectivo, tomándose de las historias clínicas de los pacientes trasplantados renales recolectados mediante la ficha de recolección de datos validada por expertos, donde se ejecutó para las variables independientes el análisis de la prueba de chi-cuadrado y mediante el modelo de regresión lineal se cuantificó la relación entre la variable dependiente y las variables independientes procesada en el programa SPSS Stadistics v. 25. Resultados: De 50 pacientes trasplantados; la frecuencia de complicaciones infecciosas fue del 88% (44). El receptor de donante cadavérico con un 86% (38), el 34% (15) presentó hipotensión durante el período intraoperatorio y de las infecciones el 64% (28) fueron de origen bacteriana siendo los pacientes adultos de condición varón el 77% (34), observando que existe evidencia significativa para los ya mencionados teniendo relación con la complicación infecciosa con un (p<0.05). Y las comorbilidades junto con la edad mostraron no tener alguna relación con la complicación infecciosa con un (p=0.082). Conclusiones: De los 50 pacientes sometidos a trasplante renal en el periodo de 10 años se observó que el 88% tuvo una complicación infecciosa, de origen bacteriano con un 64%, encontrándose al tipo de donante, complicaciones intraoperatorias, el tipo de infección y el tipo de germen factores asociados a complicaciones infecciosas.
Tecnologias De Engenharia de Software para o Desenvolvimento de Sistemas de Saúde de Código Aberto: um Mapeamento Sistemático da Literatura
Authors: Lima Luis Felipe de , Meireles Flávia , Peres Leticia
Published: July 2023

Este artigo investiga as tecnologias de engenharia de software (ES) usadas durante o desenvolvimento de sistemas de saúde de código aberto (SSCAs) por meio de um mapeamento sistemático da literatura. O mapeamento resultou na seleção de 67 estudos a partir de buscas em quatro bibliotecas digitais. Os resultados indicaram que as principais tecnologias de ES utilizadas são padrões e modelos de representação e transmissão de dados de saúde. Além disso, os resultados permitiram obter uma visão geral sobre o desenvolvimento, a disponibilização e a aplicabilidade dos SSCAs.
Development and Validation of a Psychological Resilience Scale for Mothers of Children with ASD: Calibration with Rasch-Andrich Model
Authors: Alyami Ibrahim Q.
Published: July 2023

Background: The present study aimed to develop and validate a psychological resilience scale for mothers of children with ASD using calibration with the Rasch-Andrich model.

Methods: A quantitative approach of national survey research design using an online questionnaire was applied. The cross-sectional study involves a sample of mothers of children with ASD in KSA. Purposive sampling was employed. There were 310 mothers of children with ASD. All of them filled in all questions on the scale.

Findings: Concerning unidimensionality and local independence assumptions, the first factor explains more than (20%) of the variance in score with respect to the total variance due to all factors, so it can be said that there is one factor behind the items of the scale. The separation index and reliability of the psychological resilience scale for mothers of children with ASD were at an acceptable level. The person separation reliability was 0.96, indicating an acceptable degree of confidence in replicating the placement of persons within measurement error.

Conclusion: Analysis by Item Response Theory (IRT) models allows a considerably deeper understanding of the psychometric properties of the items and scale.
Editorial
Authors: Hintz Helena Centeno
Published: July 2023

Em 2010, em uma das reuniões do Conselho Deliberativo e Científico da ABRATEF, ficou decidido que além das edições impressas da Revista da ABRATEF que coincidem com o ano do Congresso Brasileiro, haverá uma edição online. Desta forma, estreamos nesta edição o formato online.
Isabgol: Package Practices for Cultivation
Authors: Eraqui Suhel , Husain Mohammad Faizan
Published: July 2023

Isabgol is a short-stemmed annual herb that grows up to 40 cm tall. A large number of flowering shoots emerge from the plant's base. The word isabgol derives from the Persian words "isap" and "ghol," which mean horse ear and describe the shape of the seed. Psyllium, which derives from the Greek word for a flea, refers to the size, shape, and whitish color of the seed, which is the most commercially important part of this plant. The seeds are encased in capsules that open when they reach maturity. The husk of the seed is thin, boat-shaped, white, translucent, odourless, and has a mucilaginous taste. The root system is well developed, with a well-developed tap root and a few fibrous secondary roots. Isabgol is widely grown in many parts of the world. It is native to the Mediterranean region and West Asia, reaching as far north as Sutlej and Sindh in Pakistan. It is also found in the Canary Islands, Southern Spain, North Africa, the Middle East, and North-Western Asia. It has been introduced and cultivated in North Gujarat, as well as adjoining parts of Western Rajasthan and Madhya Pradesh in India. However, the crop is spreading in previously unexplored areas of the country such as Punjab, Haryana, Uttar Pradesh, and Karnataka.
Diplomacia cultural e o cosmopolitismo culinário
Authors: Badaró Monique
Published: July 2023

A gastronomia é parte integrante da cultura e identidade de uma nação e contribui para a sua reputação e prestígio no plano internacional. Em um contexto de expansão das oportunidades de mobilidade internacional e desejo de entrar em contato com culturas locais, por meio da alimentação, floresce um cosmopolitismo culinário capaz de dar visibilidade à gastronomia dos países não centrais. Esta abertura para a alteridade gastronômica deu força à noção de gastrodiplomacia entre os governos nos últimos anos. Componente da diplomacia cultural e da diplomacia pública, ela vem sendo utilizada como estratégia governamental de reconhecimento e inserção na cena internacional. No entanto, o tema permanece ainda pouco estudado no Brasil. Este artigo propõe lançar luz sobre o crescente interesse por cozinhas de todo o mundo e as políticas culturais de gastrodiplomacia, tratando o tema da comida sob o ângulo das relações internacionais.
Dual‐Engineering of Porous Structure and Carbon Edge Enables Highly Selective H2O2 Electrosynthesis
Authors: Jing Lingyan , Tian Qiang , Li Xuan , Sun Jianju , Wang Wenyi , Yang Hengpan , Chai Xiaoyan , Hu Qi , He Chuanxin
Published: July 2023

Edge engineering has emerged as a powerful strategy to activate inert carbon surfaces, and thus achieve a notable enhanced electrocatalytic activity. However, the rational manipulation of carbon edges to achieve enhanced catalytic performance remains a formidable challenge, primarily hindered by immature synthesis methods and the obscured understanding of the structure‐activity relationship. Herein, an organic–inorganic hybrid co‐assembly strategy is used to fabricate a series of mesoporous carbon nanofibers (MCNFs) with controllable edge site densities and the impact of edge population on electrochemical oxygen reduction reaction (ORR) pathways is investigated. The optimized MCNFs catalyst exhibits a remarkable 2e− ORR performance, as evidenced by a high H2O2 selectivity (>90%) across a wide potential window of 0.6 V and a large cathodic current density of −3.0 mA cm−2 (at 0.2 V vs. reversible hydrogen electrode). Strikingly, the density of carbon edge sites can be changed to tune the ORR activity and selectivity. Experimental validation and density functional theory calculations confirm that the presence of edge defects can optimize the adsorption strength of *OOH intermediates and balance the selectivity and activity of the 2e− ORR process. This study provides a new path to achieve high ORR activity and 2e− selectivity in carbon‐based electrocatalysts.
Engineering In Vitro Organ‐Structured Tumor Model for Evaluating Neoantigen‐Specific T Cell Responses in Hepatocellular Carcinoma
Authors: Xiao Jingyu , Wang Fei , Hu Xiaoyan , Li Dongli , Liu Geng , Xu Qumiao , Chen Chao , Xiang Haitao , Dong Xuan , Zhu Linnan , Yang Dishuang , Gao Yanan , Wang Meijuan , Luo Yonglun , Chao Cheng‐Chi , Li Guanglei , Guo Qiongyu
Published: July 2023

Neoantigens derived from somatic mutations in cancer cells can induce antigen‐specific T‐cell immune response for cancer immunotherapy. However, the 3D models for assessing neoepitope immunogenicity and efficacy of anti‐tumor T‐cell immune response to neoantigens are less than perfect. Here, a 3D tumor model based on recellularized liver matrix is leveraged with HepG2 cells to investigate T cell cytotoxic reactivity toward hepatocellular carcinoma (HCC) neoantigens. The whole exome sequencing (WES) data of 364 HCC patients in The Cancer Genome Atlas database are collected and 25 highly potential immunogenic neoantigens to human leukocyte antigen (HLA)‐A*02:01 molecule in silico are predicted. Six of the HCC neoantigen candidates are functionally validated with high immunogenicity by measuring cellular interferon‐γ secretion and cytotoxicity during neoantigen‐specific T‐cell immune responses in vitro. Then, the minigene of six functionally identified neoantigen peptides is constructed and the minigene‐modified GFP‐HepG2 cells are generated. Neoantigen‐specific immune response is observed with highly secreted Granzyme B, IFN‐γ, and PD‐1 when targeting the minigene‐modified GFP‐HepG2 cells in the 3D RLM HCC tumor model. Overall, the 3D RLM tumor model provides a novel strategy for preclinical assessment of the efficacy of neoantigen‐specific T cell immune response, which helps develop personalized cancer vaccines and immunotherapy treatments for HCC patients.
mFERMeta++ : Robust Multiview Facial Expression Recognition Based on Metahuman and Metalearning
Authors: Jiang Shuo , Liu Jiahang , Zhou Yanmin , Wang Zhipeng , He Bin
Published: July 2023

Facial pose variation presents a significant challenge to facial expression recognition (FER) in real‐world applications. Significant bottlenecks exist in the field of multiview facial expression recognition (MFER) including a lack of high‐quality MFER datasets, and the limited model robustness in real‐world MFER scenarios. Therefore, this article first introduces a metahuman‐based MFER dataset (MMED), which effectively addresses the issues of insufficient quantity and quality in existing datasets. Second, a conditional cascade VGG (ccVGG) model is proposed, which can adaptively adjust expression feature extraction based on the input image's pose information. Finally, a hybrid training and few‐shot learning strategy are proposed that integrates our MMED dataset with a real‐world dataset and quickly deploys it in real‐world application scenarios using the proposed Meta‐Dist few‐shot learning method. Experiments on the Karolinska Directed Emotional Face (KDEF) dataset demonstrate that the proposed model exhibits improved robustness in multiview application scenarios and achieves a recognition accuracy improvement of 28.68% relative to the baseline. It demonstrates that the proposed MMED dataset can effectively improve the training efficiency of MFER models and facilitate easy deployment in real‐world applications. This work provides a reliable dataset for the MFER studies and paves the way for robust FER in any view for real‐world deployment.
NHC‐Catalyzed Radical Tandem Cyclization/Coupling Reaction for the Synthesis of 2‐Pyrrolidinone Derivatives
Authors: Zhou Nengneng , Wang Lei , Zhao Fangli , Gao Xiang , Zhao Xiaowei , Zhang Man
Published: July 2023

A novel strategy for synthesizing structurally diverse 2‐pyrrolidinons by a NHC‐catalyzed tandem radical cyclization process has been developed. This reaction proceeds through a radical coupling approach, which not only shows broad substrate scope with excellent functional group compatibility but also is quite compatible with the secondary and tertiary radicals. By using this protocol, various potentially bioactive 2‐pyrrolidinons were facilely synthesized.
Is this the end of dried blood spots as we know it?
Authors: Halvorsen Trine Grønhaug , Reubsaet Léon
Published: July 2023

In 2017 integrated sampling and sample preparation for simplified liquid chromatography‐mass spectrometry analysis of proteins from dried blood spots were introduced. The concept, called smart samplers or smart sampling, enables proteolysis or affinity clean‐up, two common sample preparation steps in liquid chromatography‐mass spectrometric bioanalysis of proteins, to start at the moment of sampling. The idea is to utilize the time for sampling and drying to perform these time‐consuming and labour‐intensive steps. Hence, only a simplified sample preparation is necessary after the arrival of the sample in the lab. In this perspective, we present an overview of the smart sampling approach where the conventional protein analysis workflow is reshuffled to start already prior to arrival in the lab. In addition, we present a thorough discussion of integrating sample preparation steps such as proteolysis or affinity capture in the sampling. Finally, in the end, we try to answer the question if conventional dried blood spots will become obsolete in the future.
Neutrophil‐to‐lymphocyte ratio and its changes predict the 3‐month outcome and mortality in acute ischemic stroke patients after intravenous thrombolysis
Authors: Wu Qiong , Chen Hui‐Sheng
Published: July 2023

Background and purpose

The neutrophil‐to‐lymphocyte ratio (NLR) has been demonstrated as a prognostic inflammatory biomarker in ischemic stroke. The study aimed to investigate the association of NLR and its dynamic change with long‐term outcome and mortality in acute ischemic stroke (AIS) patients who received intravenous thrombolysis (IVT).

Methods

From a prospective cohort, AIS patients receiving IVT (alteplase, 0.9 mg/kg) with complete NLR data were retrospectively screened. Based on 3‐month modified Rankin scale score (mRS), patients were classified into good group (mRS 0–1) and poor outcome group (mRS 2–6), or survival group (mRS 0–5) and death group (mRS 6). Multivariate logistic regression analysis and receiver operating curve were used to identify prognostic factors and their predictive powers.

Results

A total of 259 eligible patients were enrolled in our study. Logistic regression analysis showed that NLR at 24 h (adjusted odds ratio [aOR] 1.182), 12 days (aOR 1.218) after IVT was independent predictors of 3‐month outcome with the AUC of 0.815, 0.820, respectively, whereas NLR at 24 h (aOR 1.17), 12 days (aOR 1.252) after IVT and percentage changes of NLR between admission and 24 h after IVT (aOR 1.214), and between admission and 12 days after IVT (aOR 1.233) were independent predictors of 3‐month mortality with the AUCs of 0.86, 0.902, 0.814, and 0.855, respectively.

Conclusion

The comprehensive report suggests that NLR and its dynamic changes are associated with 3‐month outcome and mortality in AIS patients after IVT with good predictive powers.
Novel arm‐width‐expandable transcatheter edge‐to‐edge repair system: Preclinical experiment and first‐in‐human study
Authors: Long Yuliang , Li Wei , Chen Shasha , Li Mingfei , Hou Shiqiang , Pan Cuizhen , Zhou Daxin , Pan Wenzhi , Ge Junbo
Published: July 2023

Background

The ValveClasp system is a novel transcatheter edge‐to‐edge repair (TEER) device with an arm‐width‐expandable clip that allows treatment of patients with only one clip more frequently.

Objectives

This study aimed to evaluate the feasibility and safety of a novel TEER device in porcine models and patients.

Methods

Fourteen young adult pigs were enrolled. A clip with an expanded arm was implanted under epicardial echocardiography and fluoroscopy guidance. Five patients with at least moderate‐to‐severe mitral regurgitation underwent TEER using the ValveClasp system to test the safety and effectiveness of the device.

Results

The device success rate was 100% (14/14) in the animal experiments, and all clips were deployed at the A2P2 segments, forming a double‐orifice mitral valve. Gross observations on day 180 showed a wide and continuous tissue bridge between the leaflets. The acute procedural success rate was 100% (5/5). Only one clip was required in all patients, and all achieved effective postoperative endpoints (grade ≤2+). During 30‐day follow‐up, no adverse events occurred. All patients' vena Contracta width (from 8.04 0.71 mm to 3.84 ± 1.18 mm, p = 0.012), mitral regurgitation area (from 12.75 ± 3.13 cm2 to 3.50 ± 1.66 cm2, p = 0.008), and left ventricular end diastolic diameter (from 52.00 ± 2.92 mm to 46.00 ± 3.08 mm, p = 0.040) were considerably decreased, without obvious mitral stenosis.

Conclusions

The novel arm‐width‐expandable ValveClasp device is safe for TEER for treating severe mitral regurgitation.
Escalation strategies, management, and outcomes of acute myocardial infarction‐cardiogenic shock patients receiving percutaneous left ventricular support
Authors: Patlolla Sri Harsha , Gilbert Olivia N. , Belford Peter M. , Morris Benjamin N. , Jentzer Jacob C. , Pisani Barbara A. , Applegate Robert J. , Zhao David X. , Vallabhajosyula Saraschandra
Published: July 2023

Background

There are limited national‐level data on the contemporary practices of mechanical circulatory support (MCS) use in acute myocardial infarction‐cardiogenic shock (AMI‐CS).

Methods

We utilized the Healthcare Cost and Utilization Project‐National/Nationwide Inpatient Sample data (2005–2017) to identify adult admissions (>18 years) with AMI‐CS. MCS devices were classified as intra‐aortic balloon pump (IABP), percutaneous left ventricular assist devices (pLVAD), or extracorporeal membrane oxygenation (ECMO). We evaluated trends in the initial device used (IABP alone, pLVAD alone or ≥2 MCS devices), device escalation, bridging to durable LVAD/heart transplantation, and predictors of in‐hospital mortality and device escalation.

Results

Among 327,283 AMI‐CS admissions, 131,435 (40.2%) had an MCS device placed with available information on timing of placement. IABP, pLVAD, and ≥2 MCS devices were used as initial device in 120,928 (92.0%), 8202 (6.2%), and 2305 (1.7%) admissions, respectively. Most admissions were maintained on the initial MCS device with 1%–1.5% being escalated (IABP to pLVAD/ECMO, pLVAD to ECMO). Urban, medium, and large‐sized hospitals and acute multiorgan failure were significant independent predictors of MCS escalation. In admissions receiving MCS, escalation of MCS device was associated with higher in‐hospital mortality (adjusted odds ratio: 1.56, 95% confidence interval:  1.38–1.75; p < 0.001). Admissions receiving durable LVAD/heart transplantation increased over time in those initiated on pLVAD and ≥2 MCS devices, resulting in lower in‐hospital mortality.

Conclusions

In this 13‐year study, escalation of MCS in AMI‐CS was associated with higher in‐hospital mortality suggestive of higher acuity of illness. The increase in number of durable LVAD/heart transplantations alludes to the role of MCS as successful bridge strategies.
Copper and Cobalt Co‐catalyzed Selective Electrooxidation of Phenol to p‐Benzoquinone Under Mild Conditions
Authors: Xu Weizhuo , Sun Yue , Li Ning , Liu Wei , Zhang Z. Conrad
Published: July 2023

Selective oxidation is still a challenge for targeted conversion of biomass derived substance to high‐value added products. Herein we report an efficient electrochemical strategy to transform phenol into p‐benzoquinone, by tandem oxidations of CuSO4 and CoSO4 catalysts in an electrolyte. Co3+ generated at the anode from oxidation of Co2+ diffuses to the solution and reacts with phenol to form hydroquinone, which is subsequently oxidized by Cu2+ in the solution selectively to p‐benzoquinone. The active metal ions (Cu2+ and Co3+) are continuously regenerated at the anode through electrooxidation and the targeted p‐benzoquinone is accumulated in the electrolyte solution. The Ultraviolet‐visible spectra and electrochemical test results reveal that Cu2+ reacts with hydroquinone immediately, and p‐benzoquinone remains stable in CuSO4 solution. By optimizing catalyst concentrations and reaction temperatures (0.2 M CuSO4, 0.005 M CoSO4 and 50 °C), the highest p‐benzoquinone yield was improved to 47 %. The developed copper‐cobalt co‐catalyzed system provides a promising approach to selectively prepare high‐value benzoquinone compounds under mild reaction conditions.
An Experimental Method to Determine the Measurement Error of Reference Electrodes within Lithium‐Ion Batteries
Authors: Rutz Daniel , Brauchle Felix , Stehle Philipp , Bauer Ingolf , Jacob Timo
Published: July 2023

Reference electrodes (REs) play a crucial role in the accurate assessment and control of battery potentials, but their confidence is overestimated. Researchers have tracked the source of the error to the RE design that blocks the lithium‐ion path between anode and cathode. These errors or potential deviations are mostly modeled or less‐frequently estimated after observing Li plating post‐mortem. This is the first study to showcase an experimental method that allows a more precise error quantification in‐operando of a RE. The key idea is to relate the error‐affected reference potential to an unaffected quantity, such as the cell dilatation. Although our experimental setups are special, this approach can also be applied to different setups and REs. Using the presented method, we provoked Li plating in NMC811/graphite pouch cells and determined the potential deviation of our perforated RE to be 12 mV under fast charging conditions. In contrast to previous studies, we found the error to be positive, offering a new explanation of the error mechanism of REs.
Exploring the impacts of novel cold plasma technology on the volatile profile, flavor, and aroma properties of fruits and vegetables—A review
Authors: Abouelenein Doaa , Caprioli Giovanni , Mustafa Ahmed M.
Published: July 2023

Cold plasma is a novel nonthermal technology that has recently numerous applications in the food industry. It destroys microorganisms, preserves food, and maintains quality without employing chemical antimicrobial agents. However, food processing by cold plasma (CP) can be associated with food quality challenges, so research on the applications of this technology and its effects on food quality are increasing. This paper reviews the effect of CP on the volatile profile, flavor, and aroma properties of fruits and vegetables. CP induces some chemical modifications in volatile compounds, and these changes vary with the CP operating conditions such as voltage, frequency, and treatment duration parameters and subsequently induces changes in the aroma and flavor of foods. The operating conditions may be properly controlled to avoid any unfavorable effects and provide more accepted food by focusing on the development of favorable flavor and aroma characteristics and reducing the incidence of undesirable ones. Also, more sophisticated techniques for sensory evaluation of processed foods should be developed and commercialized to get standardized outcomes. In conclusion, the data presented in this work highlight the possibility of flavor and aroma modifications and improvement of sensory quality in food products by using CP technology.
Use them or lose them: Are manipulatives needed to assess numeracy and geometry performance in preschool?
Authors: O'Rear Connor D. , Zippert Erica L. , Ehrman Patrick , Westerberg Lauren , Lonigan Christopher J. , Purpura David J.
Published: July 2023

In two studies, we investigated whether using three‐dimensional (3D) manipulatives during assessment aided performance on a variety of preschool mathematics tasks compared to pictorial representations. On measures of children's understanding of counting and cardinality (n = 103), there was no difference in performance between manipulatives and pictures, with Bayes factors suggesting moderate evidence in favor of the null hypothesis. On a measure of children's shape identification (n = 93), there was no difference in performance between objects and pictures, with Bayes factors suggesting moderate evidence in favor of the null hypothesis. These results suggest flexibility in the materials that can be used during assessment. Pictures, or 2D renderings of 3D objects, which can be easily printed and reproduced, may be sufficient for assessing counting and shape knowledge without the need for more cumbersome concrete manipulatives.