bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Adult Odontometrics
Authors: Kieser Julius A.
Published: February 2012

An appreciation of the genetic and environmental determinants of tooth size is fundamental to an understanding of the metric variation of teeth in humans. Thus, besides imparting a sound knowledge of the theories of dental inheritance, development and evolution, this book has an important role in demonstrating the diverse practical applications of odontometrics. A particular feature of the book is the inclusion of numerous tables which bring together a vast body of information on tooth size in different population groups. Students of oral biology, orthodontics, physical anthropology, human biology, forensic science and archaeology will find this work of great value as a text and reference source. As Professor Phillip Tobias writes in the foreword, 'The breadth of Dr Kieser's reading, and his mastery of a staggering array of anthropological, evolutionary, embryological, orthodontic and statistical concepts shine through every page of this work'.
Lignans
Authors: Ayres David C. , Loike John D.
Published: February 2012

Lignans are widely occurring plant compounds and are closely related to lignin, which forms the woody component of trees and other plants. The lignans are characterized by their dimeric composition from cinnamic acids, and they are attracting increasing attention as a result of their pharmacological properties. The volume surveys the chemical, biological and clinical properties of lignans as well as providing information on their isolation, purification, identification and chemical synthesis. The volume also explores fully the potential use of these compounds as antiviral and antitumour agents, and thus provides a wide-ranging survey of their pharmacology and chemistry. The text is fully documented and referenced and provides the only up-to-date compilation on this subject. The volume is suitable for research scientists in the fields of organic chemistry, biochemistry, oncology, pharmacology, toxicology and botany.
Continuum Mechanics and Thermodynamics
Authors: Tadmor Ellad B. , Miller Ronald E. , Elliott Ryan S.
Published: February 2012

Continuum mechanics and thermodynamics are foundational theories of many fields of science and engineering. This book presents a fresh perspective on these fundamental topics, connecting micro- and nanoscopic theories and emphasizing topics relevant to understanding solid-state thermo-mechanical behavior. Providing clear, in-depth coverage, the book gives a self-contained treatment of topics directly related to nonlinear materials modeling. It starts with vectors and tensors, finite deformation kinematics, the fundamental balance and conservation laws, and classical thermodynamics. It then discusses the principles of constitutive theory and examples of constitutive models, presents a foundational treatment of energy principles and stability theory, and concludes with example closed-form solutions and the essentials of finite elements. Together with its companion book, Modeling Materials, (Cambridge University Press, 2011), this work presents the fundamentals of multiscale materials modeling for graduate students and researchers in physics, materials science, chemistry and engineering.
At Home and under Fire
Authors: Grayzel Susan R.
Published: February 2012

Although the Blitz has come to symbolize the experience of civilians under attack, Germany first launched air raids on Britain at the end of 1914 and continued them during the First World War. With the advent of air warfare, civilians far removed from traditional battle zones became a direct target of war rather than a group shielded from its impact. This is a study of how British civilians experienced and came to terms with aerial warfare during the First and Second World Wars. Memories of the World War I bombings shaped British responses to the various real and imagined war threats of the 1920s and 1930s, including the bombing of civilians during the Spanish Civil War and, ultimately, the Blitz itself. The processes by which different constituent bodies of the British nation responded to the arrival of air power reveal the particular role that gender played in defining civilian participation in modern war.
Travels in Abyssinia and the Galla Country
Authors: Plowden Walter Chichele
Published: February 2012

In 1868, eight years after his death at the hands of Abyssinian tribesmen, the memoirs of Walter Chichele Plowden (1820–60) were published in Britain, having been prepared for publication by his brother Trevor. As the first British consul appointed to Abyssinia in 1848, Plowden was in a unique position to record contemporary local history (although as consul he was not an unequivocal success), and this book contains his detailed account of all levels of Abyssinian society. A close associate of the Emperor Tewodros (Theodore), who slaughtered 2,000 people in retaliation for Plowden's death, he includes a vivid characterisation of this important figure, and provides an exceptionally useful contemporary source for the turbulent history of Abyssinia in the mid-nineteenth century. The book also includes two maps, one of the northern frontier of Abyssinia drawn by Plowden himself, and the other modelled on the British War Office map of Abyssinia.
Seismic Imaging and Inversion
Authors: Stolt Robert H. , Weglein Arthur B.
Published: February 2012

Extracting information from seismic data requires knowledge of seismic wave propagation and reflection. The commonly used method involves solving linearly for a reflectivity at every point within the Earth, but this book follows an alternative approach which invokes inverse scattering theory. By developing the theory of seismic imaging from basic principles, the authors relate the different models of seismic propagation, reflection and imaging - thus providing links to reflectivity-based imaging on the one hand and to nonlinear seismic inversion on the other. The comprehensive and physically complete linear imaging foundation developed presents new results at the leading edge of seismic processing for target location and identification. This book serves as a fundamental guide to seismic imaging principles and algorithms and their foundation in inverse scattering theory and is a valuable resource for working geoscientists, scientific programmers and theoretical physicists.
My Early Travels and Adventures in America and Asia
Authors: Stanley Henry Morton
Published: February 2012

Sir Henry Morton Stanley (1841–1904) was a journalist and explorer renowned for his adventures in Africa. After emigrating to America in 1859, Stanley worked as a journalist for the New York Herald. In 1869 he was instructed to undertake an expedition to find the missionary David Livingstone, and the success of this mission brought him public recognition and financial success. Published in 1895, these two volumes contain Stanley's early journalistic writing as special correspondent for the Herald and the Missouri Democrat. Stanley's reports in Volume 1 cover General Hancock's military expedition against the Cheyenne and the Sioux peoples in Kansas and Nebraska, and the subsequent peace conferences between General Sherman and the Plains Indians. He paints a vivid picture of life in 1867 in this area of the United States through in-depth descriptions of the customs and living conditions of the native Indians, geographical features and military confrontations.
Journal of a Residence in Chile, during the Year 1822
Authors: Callcott Maria
Published: February 2012

Published in 1824, the journal of Maria Graham (1785–1842) depicts one woman's immersion in the culture and society of post-independence Chile. Graham, known later as Lady Callcott, travelled through India and Europe as well as South America, and her writings and reflections on these regions and their cultures, as well as other historical works, established her reputation both as a writer and later as an art historian. Graham outlines the parameters of her work in her preface and her historical Introduction: she is interested not only in what has happened to the Chileans, but in what the future holds for them and their new nation. Graham's writing reveals sensitivity to the sentimental, romantic, and gothic trends among her contemporaries, and her Journal benefits from her literary awareness.
The Letters of John Keats
Authors: Keats John
Published: February 2012

This book, published in 1895 for the centenary of the celebrated Romantic poet John Keats (1795–1821), was edited by Harry Buxton Forman (1842–1917). Forman was a Post Office administrator and a keen literary scholar, who had earlier produced important editions of Shelley and Keats. He has since become notorious for his involvement in making fake literary 'discoveries'. This centenary collection of 214 'racy, lively, inimitably good-tempered' letters by Keats aimed for completeness and contained several previously unpublished communications to addressees such as the Jeffrey family. It includes letters from Keats to his brother George (1797–1841), who lived in America, and to his fiancée Fanny Brawne (1800–65). Forman's edition of the Brawne letters had aroused controversy when it appeared in 1878, as being too personal for publication. However, Forman included them in the 1895 collection to help the reader 'complete the picture of the true Keats'.
Macaulay
Authors: Morison J. Cotter
Published: February 2012

Historian, essayist and poet, Thomas Babington Macaulay (1800–59) is described by his biographer as possessing a mind that was born wise and nurtured to a state of brilliance. With an ability to imbue his most scholarly works with a narrative power 'on a level with that of the greatest masters of prose fiction', Macaulay's multi-volume History of England assured his fame in middle-class Victorian households. Nevertheless, few today are familiar with the author's personal history. Published in the first series of English Men of Letters in 1882, this biography by James Cotter Morison (1832–88) introduces readers to the main influences on Macaulay's life and work from his childhood, through his days at Trinity College, Cambridge, to the writing of his History. The result is a sympathetic and detailed portrait of a man whose life was shaped by literature.
Études et leçons sur la Révolution Française
Authors: Aulard Alphonse
Published: February 2012

Alphonse Aulard (1849–1928) was the first French historian to use nineteenth-century historicist methods in the study of the French Revolution. Pioneered by German historians such as Leopold van Ranke, this approach emphasised empiricism, objectivity and the scientific pursuit of facts, rather than philosophical or literary concerns. Aulard's commitment to archival investigation is evidenced by the many edited collections of primary sources that appear in his extensive publication record. In these eight volumes of papers analysing the French Revolution (published 1893–1921), Aulard sought to apply the principles of historicism to reveal the truth. The work draws on earlier journal articles and lectures which Aulard delivered as Professor of the History of the French Revolution at the Sorbonne, a post he had held since 1885. Volume 4 (1904) covers education under the Terror, the rise of socialism, and the life of Georges Jacques Danton, a leading figure in the Revolution.
Études et leçons sur la Révolution Française
Authors: Aulard Alphonse
Published: February 2012

Alphonse Aulard (1849–1928) was the first French historian to use nineteenth-century historicist methods in the study of the French Revolution. Pioneered by German historians such as Leopold van Ranke, this approach emphasised empiricism, objectivity and the scientific pursuit of facts, rather than the philosophical and literary concerns that had guided earlier scholars. Aulard's commitment to archival investigation is evidenced by the many edited collections of primary sources that appear in his extensive publication record. In these eight volumes of papers analysing the French Revolution (published 1893–1921), Aulard sought to apply the principles of historicism to reveal the truth. The work draws on earlier journal articles and lectures which Aulard delivered as Professor of the History of the French Revolution at the Sorbonne, a post he had held since 1885. Volume 8 (1921) describes the annexation by France of land in the Rhine Valley, and compares the French and American Revolutions.
Geometric Analysis of Hyperbolic Differential Equations: An Introduction
Authors: Alinhac S.
Published: February 2012

Its self-contained presentation and 'do-it-yourself' approach make this the perfect guide for graduate students and researchers wishing to access recent literature in the field of nonlinear wave equations and general relativity. It introduces all of the key tools and concepts from Lorentzian geometry (metrics, null frames, deformation tensors, etc.) and provides complete elementary proofs. The author also discusses applications to topics in nonlinear equations, including null conditions and stability of Minkowski space. No previous knowledge of geometry or relativity is required.
Sudden hearing loss and pregnancy: a review
Authors: Goh A Y , Hussain S S M
Published: February 2012

Background:

Acute hearing loss is a distressing albeit rare occurrence in pregnancy. Due to its infrequent presentation, little is known of its cause, and the best management is unclear.

Objective:

To present a summary of current knowledge regarding sudden hearing loss in pregnancy and its management, by reviewing the published literature.

Data sources:

The following electronic databases: PubMed (MEDLINE), Ovid (MEDLINE), all EBM Reviews (Cochrane DSR, ACP Journal Club, DARE and CCTR) and Embase; plus a hand search of reference lists of retrieved papers.

Study selection and data extraction:

All papers retrieved using key word searches for ‘sudden hearing loss and pregnancy’ and ‘sudden deafness and pregnancy’ were reviewed. Due to the scarcity of literature, all studies identified were included in this review.

Data synthesis and conclusions:

All retrieved papers were reviewed. Sudden hearing loss is a rare occurrence during pregnancy, leading to a dearth of literature due to limited clinical experience. Audiological investigation findings for such patients remain equivocal. Recovery can be spontaneous during the postpartum period. In patients who require medical treatment, a dextran 40 infusion can be employed. There remains scope for further research, in the form of larger studies, to ascertain the best management option for this clinical problem.
Marine free-living nematodes associated with symbiotic bacteria in deep-sea canyons of north-east Atlantic Ocean
Authors: Tchesunov Alexei V. , Ingels Jeroen , Popova Ekaterina V.
Published: February 2012

Two nematode species living in association with chemoautotrophic prokaryotes were found in two deep-sea canyon/channel systems, the Whittard Canyon and Gollum Channels, north-east Atlantic. Parabostrichus bathyalis gen. nov. sp. nov. (Desmodorida: Desmodoridae: Stilbonematinae) relates to Eubostrichus Greeff 1869 but differs in having well-developed paired dorso-caudal apophyses of the gubernaculum, small pre- and postcloacal latero-ventral papillae with short apical setae, elongate tail with slender posterior portion, and the absence of thorn-like setae (porids) in males. Body of P. bathyalis is loosely covered with elongate cells of prokaryote ectosymbionts. Astomonema southwardorum Austen et al. 1993, originally found at a methane seep pockmark in the North Sea, constitutes a significant portion of nematode communities in certain areas of the deep-sea canyon/channel systems. Taxonomic difficulties within Astomonematinae are discussed in light of the character state of paired male gonads discovered in A. southwardorum. Canyon populations of A. southwardorum are characterized by frequent loss of part of the hind body and wound healing posterior to the vulva in females. Both species tend to occur in deeper subsurface layers of the bottom sediment. Abundance of the nematode species associated with aggregations of ectosymbiotic (Parabostrichus) and endosymbiotic (Astomonema) chemoautotrophic bacteria may indicate reduced conditions at sites in these deep-sea canyons/channels and suggests a potentially substantial ecological role for chemolitotrophic fauna there.
Trypanosoma cruzi Discrete Typing Units in Chagas disease patients from endemic and non-endemic regions of Argentina
Authors: CURA C. I. , LUCERO R. H. , BISIO M. , OSHIRO E. , FORMICHELLI L. B. , BURGOS J. M. , LEJONA S. , BRUSÉS B. L. , HERNÁNDEZ D. O. , SEVERINI G. V. , VELAZQUEZ E. , DUFFY T. , ANCHART E. , LATTES R. , ALTCHEH J. , FREILIJ H. , DIEZ M. , NAGEL C. , VIGLIANO C. , FAVALORO L. , FAVALORO R. R. , MERINO D. E. , SOSA-ESTANI S. , SCHIJMAN A. G.
Published: February 2012

Genetic diversity of Trypanosoma cruzi may play a role in pathogenesis of Chagas disease forms. Natural populations are classified into 6 Discrete Typing Units (DTUs) Tc I-VI with taxonomical status. This study aimed to identify T. cruzi DTUs in bloodstream and tissue samples of Argentinean patients with Chagas disease. PCR-based strategies allowed DTU identification in 256 clinical samples from 239 Argentinean patients. Tc V prevailed in blood from both asymptomatic and symptomatic cases and Tc I was more frequent in bloodstream, cardiac tissues and chagoma samples from immunosuppressed patients. Tc II and VI were identified in a minority of cases, while Tc III and Tc IV were not detected in the studied population. Interestingly, Tc I and Tc II/VI sequences were amplified from the same skin biopsy slice from a kidney transplant patient suffering Chagas disease reactivation. Further data also revealed the occurrence of mixed DTU populations in the human chronic infection. In conclusion, our findings provide evidence of the complexity of the dynamics of T. cruzi diversity in the natural history of human Chagas disease and allege the pathogenic role of DTUs I, II, V and VI in the studied population.
Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase
Authors: MANNECK THERESIA , KEISER JENNIFER , MÜLLER JOACHIM
Published: February 2012

The antimalarial drug mefloquine has promising antischistosomal properties killing haematophagous adult schistosomes as well as schistosomula. The mode of action and involved drug targets of mefloquine in Schistosoma mansoni schistosomula are unknown. In order to identify mefloquine-binding proteins and thus potential drug targets, mefloquine affinity chromatography with S. mansoni schistosomula crude extracts was performed. We found one specific mefloquine-binding protein that was identified by mass spectrometry as the glycolytic enzyme enolase (Q27877). Enolase activity assays were performed on schistosomula crude extracts and on the recombinant enolase Q27877 expressed in Escherichia coli. In schistosomula crude extracts enolase activity was inhibited by mefloquine and by the enolase inhibitor sodium fluoride, while activity of the recombinant enolase was not affected. In contrast to enolase from crude extracts, recombinant Q27877 did not bind to mefloquine-agarose. Using isothermal microcalorimetry, we next investigated the metabolic inhibition of mefloquine and 3 known glycolytic inhibitors in Schistosoma spp., namely sodium fluoride, 3-bromopyruvate and menadione on schistosomula in the presence or absence of glucose. We found that in the presence of glucose, schistosomula were less affected by mefloquine, sodium fluoride and 3-bromopyruvate, whereas glucose had no protective effect when schistosomula had been exposed to menadione. These results suggest a potential role of mefloquine as an inhibitor of glycolysis, at least in stages where other targets like haem degradation are not relevant.
The combined treatment of praziquantel with osteopontin immunoneutralization reduces liver damage inSchistosoma japonicum-infected mice
Authors: CHEN BO-LIN , ZHANG GUI-YING , WANG SHI-PING , LI QIAN , XU MEI-HUA , SHEN YUE-MING , YAN LU , GU HUAN , LI JIA , HUANG Y. L. , MU YI-BING
Published: February 2012

The aim of this study was to evaluate the therapeutic effects of osteopontin neutralization treatment on schistosome-induced liver injury in BALB/C mice. We randomly divided 100 BALB/C mice into groups A, B, C, D and group E. Mice in all groups except group A were abdominally infected with schistosomal cercariae to induce a schistosomal hepatopathological model. Mice in group C, D and group E were respectively administered with praziquantel, praziquantel plus colchicine and praziquantel plus neutralizing osteopontin antibody. We extracted mouse liver tissues at 3 and 9 weeks after the ‘stool-eggs-positive’ day, observed liver histopathological changes by haematoxylin-eosin and Masson trichrome staining and detected the expression of osteopontin, alpha-smooth muscle actin (α-SMA) and transforming growth factor-beta (TGF-β1) by immunohistochemistry, RT-PCR and Western blot. We found that praziquantel plus neutralizing osteopontin antibody treatment significantly decreased the granuloma dimension, the percentage of collagen and the expression of osteopontin,α-SMA and TGF-β1 compared to praziquantel plus colchicine treatment in both the acute and chronic stage of schistosomal liver damage (P<0·05). So we believe that the combined regimen of osteopontin immunoneutralization and anti-helminthic treatment can reduce the granulomatous response and liver fibrosis during the schistosomal hepatopathologic course.
Why infest the loved ones – inherent human behaviour indicates former mutualism with head lice
Authors: RÓZSA LAJOS , APARI PÉTER
Published: February 2012

Head lice transmit to new hosts when people lean their heads together. Humans frequently touch their heads to express friendship or love, while this behaviour is absent in apes. We hypothesize that this behaviour was adaptive because it enabled people to acquire head lice infestations as early as possible to provoke an immune response effective against both head lice and body lice throughout the subsequent periods of their life. This cross-immunity could provide some defence against the body-louse-borne lethal diseases like epidemic typhus, trench fever, relapsing fever and the classical plague. Thus the human ‘touching heads’ behaviour probably acts as an inherent and unconscious ‘vaccination’ against body lice to reduce the threat exposed by the pathogens they may transmit. Recently, the eradication of body-louse-borne diseases rendered the transmission of head lice a maladaptive, though still widespread, behaviour in developed societies.
Effects of miltefosine treatment in fibroblast cell cultures and in mice experimentally infected withNeospora caninumtachyzoites
Authors: DEBACHE KARIM , HEMPHILL ANDREW
Published: February 2012

Miltefosine was investigated for its activity againstNeospora caninumtachyzoitesin vitro,and was shown to inhibit the proliferation ofN. caninumtachyzoites cultured in human foreskin fibroblasts (HFF) with an IC50of 5·2μM. Treatment of infected cells with 25μM miltefosine for a period of 10 h had only a parasitostatic effect, while after 20 h of treatment parasiticidal effects were observed. This was confirmed by transmission electron microscopy ofN. caninum-infected and miltefosine-treated HFF. Administration of miltefosine toN. caninum-infected Balb/c female mice at 40 mg/kg/day for 14 days resulted in 6 out of 10 mice exhibiting weight loss, ruffled coat and apathy between days 7 and 13 post-infection. In the group that received placebo, only 2 out of 8 mice succumbed to infection, but the cerebral burden was significantly higher compared to the miltefosine treatment group. In a second experiment, the time-span of treatment was reduced to 5 days, and mice were maintained without further treatment for 4 weeks. Only 2 out of 9 mice in the miltefosine treatment group exhibited signs of disease, while 8 out of 10 mice succumbed to infection in the placebo group. These results showed that miltefosine hampered the dissemination of parasites into the CNS during experimentalN. caninuminfection in mice.
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis
Authors: SIMARRO P. P. , FRANCO J. , DIARRA A. , POSTIGO J. A. RUIZ , JANNIN J.
Published: February 2012

Despite the fact that eflornithine was considered as the safer drug to treat human African trypanosomiasis (HAT) and has been freely available since 2001, the difficulties in logistics and cost burden associated with this drug meant that the toxic melarsoprol remained the drug of choice. The World Health Organization responded to the situation by designing a medical kit containing all the materials needed to use eflornithine, and by implementing a training and drugs distribution programme which has allowed a transition to this much safer treatment. The introduction of the combination of nifurtimox and eflornithine (NECT) has accelerated the shift from melarsoprol to the best treatment available, due to reduced dosage and treatment time for eflornithine that has significantly lessened the cost and improved the burden of logistics encountered during treatment and distribution. The decrease in the use of more dangerous but cheaper melarsoprol has meant a rise in the per patient cost of treating HAT. Although NECT is cheaper than eflornithine monotherapy, an unexpected consequence has been a continuing rise in the per patient cost of treating HAT. The ethical decision of shifting to the best available treatment imposes a financial burden on HAT control programmes that might render long-term application unsustainable. These factors call for continuing research to provide new safer and more effective drugs that are simple to administer and cheaper when compared to current drugs.
Shedding Light on the Conspiracy: A Reply to ‘The Sacred Conspiracy: Religion, Nationalism, and the Crisis of Internationalism’
Authors: ZUCCA LORENZO
Published: February 2012

Religion plays a central role at the global political level despite being often portrayed as dead, marginal, or irrelevant. The way in which it plays that role, however, is not always immediately apparent or transparent. Professor Berman's essay attempts to illustrate the various ways – direct and indirect – in which religion is still central in today's debates about international law and politics. He does that by bringing us back to the interwar period, which saw an abundant flurry of arguments about international law, nationalism, and religion. He focuses in particular on the avant-garde movement led by Georges Bataille, who called for the shaking of civil society by appealing to the destabilizing forces of the (left) sacred in opposition to the conservative forces of the (right) sacred. Bataille's key insight is that religion has a contagious energy that is far more sweeping and powerful than the mere force of Western rationality. From this viewpoint, (international) law is incapable of taming the crisis of the West and of keeping at bay the perils of religion and nationalism.
The Terms of Reference of the Commission on the Limits of the Continental Shelf: A Creeping Legal Mandate
Authors: KUNOY BJØRN
Published: February 2012

The Commission on the Limits of the Continental Shelf is neither fish nor fowl. Its primary purpose is to consider coastal states’ proposed limits of the outer continental shelf and to make recommendations thereto. Albeit the establishment of the outer limits is an act within the sole discretion of a state, the role of the Commission in the establishment of such limits is of pivotal importance. Due to its mandate, it can reasonably be argued that the Commission is, by way of implication, deemed to be vested with rights that cannot be seen to be limited to a technical review stricto sensu. This paper seeks to determine the exact terms of reference of the Commission and to what extent it comprises powers to undertake legal interpretations of the Convention. It will be concluded that a fair balance governs the operations of the Commission, although they, at times, comprise tasks that are essentially of a legal nature.
The Principle of Non-Intervention 25 Years after the Nicaragua Judgment
Authors: KOHEN MARCELO
Published: February 2012

This article focuses on the analysis by the International Court of Justice of the principle of non-intervention in domestic affairs in its judgment of 27 June 1986 in the case concerning Military and Paramilitary Activities in and against Nicaragua and contrasts it with the evolution of international law and practice in this field. It is proposed that the Court's 1986 analysis not only remains of actuality today, but also constitutes a precursor to legal developments that have since taken place. This is particularly the case with regard to the relationship between the protection of human rights on the one hand and the safeguard of state sovereignty and the collective security regime on the other. The 1986 judgment helped to clarify the content of humanitarian assistance. It constituted the starting point for the development of this concept in a series of GA resolutions that were subsequently adopted. The controversial doctrine of ‘humanitarian intervention’, as well as state practice in violation of this principle, in no way led to modifying existing international law. Similarly, the new concept of ‘responsibility to protect’, which places emphasis on collective security and discounts unilateral action, has not led to the disappearance of the principle of non-intervention either.
Amacrine cell-mediated input to bipolar cells: Variations on a common mechanistic theme
Authors: GRIMES WILLIAM N.
Published: February 2012

Feedback is a ubiquitous feature of neural circuits in the mammalian central nervous system (CNS). Analogous to pure electronic circuits, neuronal feedback provides either a positive or negative influence on the output of upstream components/neurons. Although the particulars (i.e., connectivity, physiological encoding/processing/signaling) of circuits in higher areas of the brain are often unclear, the inner retina proves an excellent model for studying both the anatomy and physiology of feedback circuits within the functional context of visual processing. Inner retinal feedback to bipolar cells is almost entirely mediated by a single class of interneurons, the amacrine cells. Although this might sound like a simple circuit arrangement with an equally simple function, anatomical, molecular, and functional evidence suggest that amacrine cells represent an extremely diverse class of CNS interneurons that contribute to a variety of retinal processes. In this review, I classify the amacrine cells according to their anatomical output synapses and target cell(s) (i.e., bipolar cells, ganglion cells, and/or amacrine cells) and discuss specifically our current understandings of amacrine cell-mediated feedback and output to bipolar cells on the synaptic, cellular, and circuit levels, while drawing connections to visual processing.
Protein–phytate interactions in pig and poultry nutrition: a reappraisal
Authors: Selle Peter H. , Cowieson Aaron J. , Cowieson Nathan P. , Ravindran V.
Published: February 2012

Protein–phytate interactions are fundamental to the detrimental impact of phytate on protein/amino acid availability. The inclusion of exogenous phytase in pig and poultry diets degrades phytate to more innocuous esters and attenuates these negative influences. The objective of the present review is to reappraise the underlying mechanisms of these interactions and reassess their implications in pig and poultry nutrition. Protein digestion appears to be impeded by phytate in the following manner. Binary protein–phytate complexes are formed at pH levels less than the isoelectric point of proteins and complexed proteins are refractory to pepsin digestion. Once the protein isoelectric points are exceeded binary complexes dissociate; however, the isoelectric point of proteins in cereal grains may be sufficiently high to permit these complexes to persist in the small intestine. Ternary protein–phytate complexes are formed at pH levels above the isoelectric point of proteins where a cationic bridge links the protein and phytate moieties. The molecular weights of protein and polypeptides in small-intestinal digesta may be sufficient to allow phytate to bind nutritionally important amounts of protein in ternary complexes. Thus binary and ternary complexes may impede protein digestion and amino acid absorption in the small intestine. Alternatively, phytate may interact with protein indirectly.Myo-inositol hexaphosphate possesses six phosphate anionic moieties (HPO42–) that have strong kosmotropic effects and can stabilise proteins by interacting with the surrounding water medium. Phytate increases mucin secretions into the gut, which increases endogenous amino acid flows as the protein component of mucin remains largely undigested. Phytate promotes the transition of Na+into the small-intestinal lumen and this suggests that phytate may interfere with glucose and amino acid absorption by compromising Na+-dependent transport systems and the activity of the Na pump (Na+-K+-ATPase). Starch digestion may be depressed by phytate interacting with proteins that are closely associated with starch in the endosperm of cereal grains. While elucidation is required, the impacts of dietary phytate and exogenous phytase on the site, rate and synchrony of glucose and amino acid intestinal uptakes may be of importance to efficient protein deposition. Somewhat paradoxically, the responses to phytase in the majority of amino acid digestibility assays in pigs and poultry are equivocal. A brief consideration of the probable reasons for these inconclusive outcomes is included in this reappraisal.
Establishment of a new, secure colony of Endangered Bermuda Petrel Pterodroma cahow by translocation of near-fledged nestlings
Authors: CARLILE NICHOLAS , PRIDDEL DAVID , MADEIROS JEREMY
Published: February 2012

Until recently, Bermuda Petrel Pterodroma cahow (IUCN Category: ‘Endangered’) bred only in sub-optimal habitat on four small islets in north-east Bermuda. Although intensive management of the population since 1962 has led to a substantial increase in population size (now approaching 100 pairs), the nesting habitat on these four islets is being increasingly inundated, eroded and destroyed by high seas associated with hurricanes and storms. To ensure the long-term conservation of the species a decision was made to establish a new colony at a more secure site on nearby Nonsuch Island, where they once bred in large numbers. Between 2004 and 2008, 104 near-fledged nestlings were translocated to artificial burrows on Nonsuch Island, where they were hand-fed meals of fish and squid. All but three translocated birds fledged successfully, with the first returning to Nonsuch Island in February 2008. The first Bermuda Petrel egg on Nonsuch Island in more than 300 years was laid in January 2009, and the resultant fledgling departed in June of the same year. By the end of the 2009/10 breeding season, a total of 18 Bermuda Petrels have been recorded on Nonsuch Island, 17 were translocated as near-fledged nestlings, and one bird came from the existing colonies. A total of five eggs have been produced, resulting in two fledglings. The establishment of this new colony, at a site that is much more secure than the existing nesting sites, greatly enhances the conservation prospects of the species and demonstrates the importance of translocation as a tool for the conservation of threatened seabirds.
The changing abundance and distribution of Greater White-fronted Geese Anser albifrons in the Yangtze River floodplain: impacts of recent hydrological changes
Authors: ZHAO MEIJUAN , CONG PEIHAO , BARTER MARK , FOX ANTHONY D. , CAO LEI
Published: February 2012

Count data show that wintering Greater White-fronted Goose Anser albifrons numbers in their Chinese stronghold (the Yangtze River catchment) have fallen from about 140,000 in the late 1980s and early 1990s to c.18,000 now, despite increases in the overall flyway population (mostly wintering in South Korea and Japan). Declines have occurred in Jiangxi, but most markedly in Hunan (predominantly at East Dongting Lake) where the decline has been steady since 2003/2004, with few left from 2008/2009 onwards. Numbers have increased substantially in Anhui (predominantly at Shengjin Lake), which now supports more Greater White-fronted Geese than Jiangxi and Hunan combined. The species appears a habitat specialist in China, confined to grazing short-sward recessional Carex sedge meadows. At East Dongting Lake, reductions in Greater White-fronted Geese numbers correlated with declines in availability of suitable sedge swards, caused by earlier water table recession, which in recent years has meant swards were too tall for geese to utilise from their arrival in autumn. The hydrological changes are most probably due to the commissioning of the Three Gorges Dam in mid-2003. At Shengjin Lake, the increases may be due to recent stable first exposure dates and slow water recession rates which favour short Carex swards attractive to geese; high buffalo grazing density at this lake may also assist in maintaining suitable sward heights. These hypotheses require investigation.
Anomalies of the coronary arteries: nomenclature and classification
Authors: Jacobs Marshall L. , Mavroudis Constantine
Published: February 2012

Abnormalities of the coronary arterial circulation represent a broad spectrum of anomalies. Some of these coronary arterial anomalies are of little clinical significance and are generally discovered either as incidental findings at autopsy or at the time of diagnostic coronary angiography in patients with atherosclerotic ischaemic cardiac disease. Some of these coronary arterial anomalies, however, are associated with a markedly abnormal natural history that may include significant cardiac morbidity very early in infancy, or increased risk of cardiac sudden death in childhood or adolescence. It is therefore important that we have a system for the naming and classification of these anomalies, to stratify them according to the associated risk and to develop rational approaches to evaluation and management. To apply any system of nomenclature reliably and responsibly, it is essential that each term be associated with a definition that is known and accepted by users of terminology. Such definitions are included in the specifications of both the Society of Thoracic Surgeons Congenital Heart Surgery Database and the European Association for Cardio-Thoracic Surgery Congenital Heart Surgery Database. These databases use the Diagnostic Short List of the version of the International Paediatric and Congenital Cardiac Code derived from the nomenclature of the International Congenital Heart Surgery Nomenclature and Database Project of the European Association for Cardio-Thoracic Surgery and the Society of Thoracic Surgeons. This article will provide the nomenclature and definitions used by these databases for anomalies of the coronary arteries.
Undernutrition among Kenyan children: contribution of child, maternal and household factors
Authors: Gewa Constance A , Yandell Nanette
Published: February 2012

Objective

To examine the contribution of selected child-, maternal- and household-related factors to child undernutrition across two different age groups of Kenyan under-5s.

Design

Demographic and Health Survey data, multistage stratified cluster sampling methodology.

Setting

Rural and urban areas of Kenya.

Subjects

A total of 1851 children between the ages of 0 and 24 months and 1942 children between the ages of 25 and 59 months in Kenya.

Results

Thirty per cent of the younger children were stunted, 13 % were underweight and 8 % were wasted. Forty per cent of the older children were stunted, 17 % were underweight and 4 % were wasted. Longer breast-feeding duration, small birth size, childhood diarrhoea and/or cough, poor maternal nutritional status and urban residence were associated with higher odds of at least one form of undernutrition, while female gender, large birth size, up-to-date immunization, higher maternal age at first birth, BMI and education level at the time of the survey and higher household wealth were each associated with lower odds of at least one form of undernutrition among Kenyan children. The more proximal child factors had the strongest impact on the younger group of children while the intermediate and more distal maternal and household factors had the strongest impact on child undernutrition among the older group of children.

Conclusions

The present analysis identifies determinants of undernutrition among two age groups of Kenyan pre-school children and demonstrates that the contribution of child, maternal and household factors on children's nutritional status varies with children's age.
Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats
Authors: Mairesse Jerome , Silletti Viviana , Laloux Charlotte , Zuena Anna Rita , Giovine Angela , Consolazione Michol , van Camp Gilles , Malagodi Marithe , Gaetani Silvana , Cianci Silvia , Catalani Assia , Mennuni Gioacchino , Mazzetta Alessandro , van Reeth Olivier , Gabriel Cecilia , Mocaër Elisabeth , Nicoletti Ferdinando , Morley-Fletcher Sara , Maccari Stefania
Published: February 2012

Agomelatine is a novel antidepressant acting as an MT1/MT2 melatonin receptor agonist/5-HT2C serotonin receptor antagonist. Because of its peculiar pharmacological profile, this drug caters the potential to correct the abnormalities of circadian rhythms associated with mood disorders, including abnormalities of the sleep/wake cycle. Here, we examined the effect of chronic agomelatine treatment on sleep architecture and circadian rhythms of motor activity using the rat model of prenatal restraint stress (PRS) as a putative ‘aetiological’ model of depression. PRS was delivered to the mothers during the last 10 d of pregnancy. The adult progeny (‘PRS rats') showed a reduced duration of slow wave sleep, an increased duration of rapid eye movement (REM) sleep, an increased number of REM sleep events and an increase in motor activity before the beginning of the dark phase of the light/dark cycle. In addition, adult PRS rats showed an increased expression of the transcript of the primary response gene, c-Fos, in the hippocampus just prior to the beginning of the dark phase. All these changes were reversed by a chronic oral treatment with agomelatine (2000 ppm in the diet). The effect of agomelatine on sleep was largely attenuated by treatment with the MT1/MT2 melatonin receptor antagonist, S22153, which caused PRS-like sleep disturbances on its own. These data provide the first evidence that agomelatine corrects sleep architecture and restores circadian homeostasis in a preclinical model of depression and supports the value of agomelatine as a novel antidepressant that resynchronizes circadian rhythms under pathological conditions.
Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus
Authors: Segawa Masahiro , Morinobu Shigeru , Matsumoto Tomoya , Fuchikami Manabu , Yamawaki Shigeto
Published: February 2012

Electroconvulsive therapy is the most effective treatment for antidepressant-resistant depression, although its mechanism has not been fully elucidated. Previous studies have demonstrated that electroconvulsive seizures (ECS) induce expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, in contrast with mature BDNF (mBDNF) known to have antidepressant effects, its precursor (pro-BDNF) has harmful effects on neurons. We therefore hypothesized that efficient processing of pro-BDNF is a critical requirement for the antidepressant effects of ECS. We found that single administration of ECS rapidly increased not only hippocampal levels of pro-BDNF but also those of prohormone convertase 1 (PC1) and tissue-plasminogen activator (t-PA), which are proteases involved in intra- and extracellular pro-BDNF processing, respectively. Interestingly, pro-BDNF and t-PA levels were increased in hippocampal synaptosomes after single ECS, suggesting their transport to secretory sites. In rats receiving 10-d repeated ECS, accumulation of pro-BDNF and a resultant increase in mBDNF levels were observed. While t-PA levels increased and accumulated following repeated ECS, PC1 levels did not, suggesting that intracellular processing capacity is limited. Finally, chronic administration of imipramine significantly increased mBDNF levels, but not pro-BDNF and protease levels, indicating that the therapeutic mechanism of imipramine differs from that of ECS. Taken together, these results suggest that, while intra- and extracellular proteases are involved in pro-BDNF processing in single ECS, t-PA plays a dominant role following repeated ECS. Such efficient pro-BDNF processing as well as strong induction of BDNF expression may contribute to the antidepressant effects of ECS.
Assessing genetic diversity, population structure and gene flow in the Korean red bean [Vigna angularis(Willd.) Ohwi & Ohashi] using SSR markers
Authors: Banni Kim , Moe Kyaw Thu , Park Yong-Jin
Published: February 2012

Red bean, also known as azuki bean [Vigna angularis(Willd.) Ohwi & Ohashi], belongs to a group of legumes (familyFabaceae). The nameazukiis a transliteration of the native Japanese name from the Chinese wordShōzu, which means small bean. In Korea, it is known aspat. In total, 178 red bean accessions were taken to analyse the genetic diversity, population structure and gene flow using 39 polymorphic simple sequence repeat markers. A total of 431 alleles were detected, with an average of 11 alleles per locus, among the 178 tested red bean accessions. Forty-six specific alleles were identified with 20 loci. Locus CEDG090 had the highest number (n = 22) of alleles, whereas only two alleles were observed at loci CEDG144 and CEDC018. The proportion of different alleles for microsatellite loci was analysed using a microsatellite toolkit. In locus CEDG029, one allele was shared in all the three groups of varieties and species, and three alleles were shared between the wild ancestors and cultivated varieties, while in locus CEDG090, one allele was shared in all the three groups and 12 alleles were shared between the wild ancestors and cultivated varieties. Our findings describe the genetic relationships and population structure of the red bean in Korea and will be useful for designing effective breeding programmes and broadening the genetic base of commercial varieties. Moreover, the results demonstrate substantial gene flow from the red bean to nearby wild relatives in a given region.