bluuebunny/crossref_metadata_2025 huggingface dataset:
Pioglitazone Nanoparticles Development, Characterization, Optimization, and a Zebrafish Model Evaluation of its Teratogenic Safety
Authors: Saha Plaban , Sarkar Subhajit , Ghosh Rakesh , Chakraborty Mainak , Mukherjee Swarupananda , Karati Dipanjan
Published: April 2024

Background:

New nanoparticles (NPs) and biomaterials are utilized more frequently in
biological research for vaccinations, diagnostic procedures, and drug administration. Nanomaterials
are materials with d50 value from 1 to 100nm. They are also found in various consumer goods, the
environment, and work. Thus, it has become crucial for the appropriate development of nanotechnology
to assess the safety and potential therapeutic applications of these nanomaterials. The BCS
Cass II medication pioglitazone hydrochloride, used to treat hypoglycaemia, has poor bioavailability
after oral treatment because it dissolves poorly in gastrointestinal fluids.

background:

New nanoparticles and biomaterials are utilized more frequently in biological research for vaccinations, diagnostic procedures, and drug administration. They are also found in various consumer goods, the environment, and work. Thus, it has become crucial for the appropriate development of nanotechnology to assess the safety and potential therapeutic applications of these nanomaterials. The BCS Cass II medication pioglitazone hydrochloride, used to treat hypoglycaemia, has poor bioavailability after oral treatment because it dissolves poorly in gastrointestinal fluids.

Objective:

This study aimed to create adjusted pioglitazone nanoparticles to decrease dose-related
side effects and prolong its release when used against type 2 diabetes.

objective:

This study aimed to create adjusted pioglitazone nanoparticles to decrease dose-related side effects and prolong its release when used against type 2 diabetes

Methods:

The emulsion solvent evaporation approach was used to create nanoparticles utilising
HPMC K15M and Eudragit S100 as polymers, and Tween 80 as a surfactant. On framed nanoparticles,
in-vitro evaluation approaches for drug-polymer compatibility, percentage yield, particle size,
zeta potential, polydispersity index, surface morphology, encapsulation effectiveness, and in-vitro
drug release study were used, followed by in-vivo acute toxicity experiment.

Conclusion:

From the obtained data, it can be said that a suitable optimized formulation of pioglitazone
nanoparticles was prepared, which offered extended drug release of 95% in 10 hours.
Synthesis of Ag and AgCl Nanoparticles using Klasea latifolia and Klassa leptoclada Extracts and Assessment of the Antimicrobial Properties of the Synthesized Nanoparticles and Antioxidant Properties of the Extracts
Authors: Abedi Akram , Firoznia Ali , Izanloo Cobra
Published: April 2024

Background:

In green synthesis, metal ions are transformed into nanoparticles through
a simple reaction, without the need for surfactants, specific conditions, and other stabilizing
agents.

Methods:

This study performed the biosynthesis of silver nanoparticles using the extract of
Klasea latifolia and Klasea leptoclada.

Results:

Nanoparticles were characterized using the SEM, XRD, UV-Visible Spectroscopy, and
EDS methods. The antibacterial properties of the extracts and synthesized nanoparticles were evaluated
against Staphylococcus aureus, Bacillus cereus, and Escherichia coli using the agar disk-diffusion
and well-diffusion. The antioxidants of the herbs were investigated using the DPPH and
FRAP methods, and the IC50 of the extracts was determined as well. The results showed that, although
no chlorinated compounds were added to the reaction medium, in addition to silver nanoparticles,
silver chloride nanoparticles were also synthesized. The synthesized nanoparticles were
spherical (size: 27-38 nm) and had uniform size distribution. Furthermore, the synthesized nanoparticles
and extracts exhibited significant antibacterial activity.

Conclusion:

Many plants have been used for the biosynthesis of silver nanoparticles, but the advantage
of using the extract of K.latifolia and K. leptoclada was that in addition to synthesizing silver
nanoparticles, silver chloride nanoparticles were also synthesized.
Unethical Clinical Trials and the Third-World Countrie
Authors: Tahir Fatima , Waqar Walifa
Published: April 2024

Although human experimentation has greatly increased our understanding of
the human body and diseases, there are still occasions when limits of morality are
crossed during clinical trials. Illiteracy, poverty, corrupt health practitioners, and lack
of law enforcement in developing countries have led to an increase in the exploitation
of people as guinea pigs for trial purposes. These unethical clinical trials in Third
World countries have caused an inferiority complex and a general mistrust in the
healthcare system. It is the duty of the physician and scientists involved in medical
research to protect the life, health, and integrity of research subjects, for which strict
regulations are a necessity.
Pedestrian crossing: Analysis of habits and compliance through unsignalized crosswalk in the city of Kigali
Authors:   Department of Civil, Environment and Geomatics Engineering, College of Science and Technology, University of Rwanda, Kigali, Rwanda, Nkurunziza David , Kumaran G. Senthil ,   Department of Civil Engineering and Construction, The Copperbelt University, Kitwe, Zambia, Tafahomi Rahman ,   Department of Architecture, College of Science and Technology, University of Rwanda, Kigali, Rwanda, Faraja Irumva Augustin ,   Researcher at Relief Solutions Ltd, Kigali, Rwanda
Published: April 2024

Pedestrian safety is a global issue that can be improved by monitoring and adjusting walking behaviors. This study focuses on how people walk across streets without traffic signals. It looks at whether pedestrians follow the rules and regulations for safely crossing streets. The unique aspect of this research is that it examines pedestrian behaviors on roads with two lanes for two-way traffic at various informal crosswalks rather than on one-way streets. The researchers watched video recordings to study different instances of people crossing streets. They found that 27.21% of pedestrians followed the safety rules when crossing, but a significant number did not and should be taught better crossing practices. The study identified three main behaviors that often led to rule violations: not looking both ways before crossing, being distracted, and not crossing cautiously. Pedestrians who were cautious were much more likely to follow the crossing rules compared to those moving at any speed, and those not distracted were more likely to follow the rules than those who were cautious. Additionally, 32.05% of pedestrians were distracted by activities like using phones, talking, or wearing headphones. Among these, 17.7% walked directly across the crosswalk, and 26.21% crossed in a diagonal or zigzag pattern. The study also found that 60% to 87% of the observed behaviors could predict whether a pedestrian would follow crossing rules based on statistical models.
The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial
Authors: Cardinale Fabio , Barattini Dionisio Franco , Sbrocca Federica , Centi Alessandro , Giuntini Greta , Morariu Bordea Maria , Herteg Dorina , Rosu Serban , Matei Cristian Radu
Published: April 2024

Background

A dietary supplement containing Pelargonium sidoides extract, propolis, zinc, and honey has been recently developed and proven to be an effective adjuvant in clinical practice for seasonal diseases and the treatment of respiratory tract disorders.

Objective

This trial aims to verify the efficacy of the tested dietary supplement in a pediatric population with acute tonsillopharyngitis/rhinopharyngitis (ATR).

Methods

The trial includes children aged between 3 and 10 years with ATR ≤48 h, a negative rapid test for beta-hemolytic streptococcus or culture identification of nasal and/or pharyngeal exudates, and SARS-CoV-2 infection. The dietary supplement tested is an oral solution already on the market based on Pelagon P-70 (equivalent to Pelargonium sidoides d.e. 133.3 mg/100 ml), propolis, zinc, and honey. The product is administered at 5 ml 3 times a day for 6 days for children younger than 6 years and 10 ml 3 times a day for 6 days for children older than 6 years. The study design is open label, randomized, and controlled, with the tested dietary supplement plus standard of care (SoC) versus SoC alone. Patients are enrolled from 3 sites in Romania. The change in Tonsillitis Severity Score and number of treatment failures (using ibuprofen or high-dose paracetamol as rescue medication) are the primary end points. Based on the Tonsillitis Severity Score and the 2-sample comparison of the means formula with a 5% significance level, 80% power, and a minimally clinically important difference of 2 (SD 3.85) points, 120 patients are required. To account for potential screening failures and dropouts, we need to screen a population of approximately 150 children.

Results

Patient enrollment began on June 3, 2021 (first patient’s first visit), and ended on August 12, 2021 (last patient’s last visit). The data collection period was from June 3, 2021, to September 16, 2021. The study was funded in February 2023. Data analysis is currently ongoing (April 2024). We expect the results to be published in a peer-reviewed clinical journal in the third quarter of 2024 and presented at scientific meetings in the last quarter of 2024.

Conclusions

The data from this trial may help identify new adjuvant treatments for children with ATR when streptococcal infection is excluded by a negative rapid test, thereby avoiding unnecessary antibiotic administration.

Trial Registration

ClinicalTrials.gov NCT04899401 https://clinicaltrials.gov/study/NCT04899401

International Registered Report Identifier (IRRID)

DERR1-10.2196/53703
Fitbits for Assessment of Physical Activity and Sleep in Pediatric Pain: Feasibility, Acceptability, and Perspectives (Preprint)
Authors: Nestor Bridget A , Baumer Andreas M , Chimoff Justin , Delecourt Benoit , Koike Camila , Tacugue Nicole , Brusseau Roland , Roy Nathalie , Gaytan-Fuentes Israel A , Sethna Navil , Wallace Danielle , Kossowsky Joe
Published: April 2024

BACKGROUND

Consumer-grade wearables, such as Fitbits, are a promising, cost-effective methodology for objectively assessing sleep and physical activity in youth with pain.

OBJECTIVE

The current study investigated the acceptability and feasibility of implementing Fitbits for youth with acute and chronic pain in and out of hospital settings while maintaining data security and patient confidentiality.

METHODS

We investigated participant experience of Fitbit usage over three to four weeks for a sample of youth with acute pain undergoing surgical procedures (N=34, mean age=14.46, SD=3.70, 47.06% female) and a sample of youth with chronic pain enrolled in an intensive interdisciplinary pain treatment program (N=28, mean age=15.00, SD=2.33, 17.86% female). We assessed the acceptability of Fitbit usage through survey items probing comfortability (0=extremely uncomfortable to 10=extremely comfortable), perceived burdensomeness (0=not burdensome at all to 10=extremely burdensome), and open-ended issues or concerns. Feasibility was assessed by tracking the daily compliant wear of the Fitbit device, which was operationalized as more than 600 minutes of daily wear time. We created an automated data pipeline to ensure data security, patient confidentiality, and quality.

RESULTS

Acceptability findings revealed high levels of reported comfort (acute pain: M=8.56, SD=1.43; chronic pain: M=8.27, SD=1.69) and low levels of perceived burdensomeness (acute: M=0.68, SD=1.17; chronic: M=1.15, SD=1.38) related to Fitbit wearing in both samples. Transient concerns of mild wrist irritation and sleep discomfort were occasionally reported across both samples (15.79% of participants). Feasibility findings indicated high feasibility (acute: median compliance rate of 86.67%; chronic: median compliance rate of 96.65%) for the study duration in both samples.

CONCLUSIONS

These findings support using Fitbits as an acceptable and feasible method of objective data collection regarding sleep and physical activity for youth with pain. Findings also highlight the logistics of implementing consumer-grade wearable devices throughout all stages of the clinical research process.
representación mental de la duda a través del tiempo: gramaticalización y esquemas mentales
Authors: Cordova Parra Karime
Published: April 2024

El sustantivo duda ha sido foco de interés de diversos estudios dentro de múltiples construcciones discursivas. Se ha descrito el funcionamiento de estas unidades y el cambio semántico que experimentan al adquirir nuevos contextos de uso; sin embargo, fuera de estos escenarios, no se ha puesto interés en determinar los cambios que ha sufrido como nominal, los cuales pudieron haber contribuido a su construccionalización. Esta investigación es un acercamiento, si bien general, a los cambios que el nominal duda ha mostrado desde el siglo XIII hasta inicios del XXI en cuanto a su esquema de imagen. Es decir, se realiza una descripción de las distintas conceptualizaciones de la duda a lo largo del tiempo, partiendo del análisis de la clase de verbo con que concurre. De este modo, se puede observar una correlación entre los ámbitos de locación, existencia y posesión en las construcciones en las que ocurre duda, así como la contribución de estos dominios a la generalización de contextos de uso del sustantivo. Si bien esta investigación tiene como base una explicación de los datos a partir de la teoría de gramaticalización, se apunta a la semántica de duda desde la noción de esquema de imagen propuesta por la gramática cognitiva, asumiendo que la asociación entre la experiencia del usuario y una unidad gramatical es parte de su conceptualización, al ser recurrente, quedar esquematizada en la lengua y ser codificada en la sintaxis.
De lo “ridículo” e “inútil” a lo “importante” y “necesario”: la inclusión discursiva desde una mirada transdisciplinar
Authors: Cepeda Ruiz Cristal Yeseidy , Avila Sánchez Kaleb
Published: April 2024

El discurso inclusivo o incluyente se ha convertido, en las últimas décadas, en un tema llamativo y controversial. Son cada vez más las mesas temáticas, los artículos académicos y las publicaciones en redes sociales y medios masivos sobre el tema. No obstante, el debate se ha dado, por lo general, en contextos separados: la lingüística por un lado y los estudios de género por otro. Esto ha generado una visión parcializada y ha retrasado el estudio científico del fenómeno. En este documento ofrecemos un diálogo interdisciplinar acerca de algunos aspectos que consideramos relevantes para comprender el tópico: el nexo entre el discurso y la realidad, el cambio social, la discriminación, el cambio lingüístico y los efectos generados por la discusión unilateral. Para ello, en primer lugar partimos de la idea de que la lengua no es un sistema neutral, sino un instrumento social al servicio de procesos identitarios e ideológicos; en segundo lugar, empleamos, además de nociones teóricas transdisciplinares, información extraída de la revisión de varias guías de estilo para el discurso inclusivo o incluyente, así como las opiniones de personas dentro de la comunidad LGBTTTIQ+ y fuera de ella que participaron en una encuesta indirecta en dos grupos focales.
Estado Social e Luta de Classes na América Latina
Authors: Rezende Tavares Hugo
Published: April 2024

Este trabalho busca analisar e problematizar algumas implicações do Estado Social em sua relação com a luta de classes. Nas últimas décadas, em toda América Latina, movimentos político-partidários progressistas de esquerda tentaram instrumentalizar o Estado, sob uma forma primitiva de Estado Social, para mediar a disputa entre capital e trabalho e suas classes representativas por meio de uma conciliação social. Argumentamos que esse processo que resultou, e vem resultando, no fortalecimento de uma direita ultraconservadora neofascista, apresenta um problema teórico de impossibilidade do uso instrumental do Estado em favor da organização de um processo social revolucionário. É necessário entender os limites transformadores da forma Estado com o intuito de criar uma frente organizada de luta contra as opressões sociais e domínio do capital.
Finding Advisors in Collaborative Environment with Fine-Grained Knowledge Sharing
Authors: Yawale Prof. N. M. , Taware Mrunal , Pathan Aarzoo , Sonar Shreyash , Sute Vansh
Published: April 2024

Abstract: As the digital world continues to expand, traditional search engines face difficulties in the ability to provide users with excellent and rapid information retrieval. Additionally, users have shown a low tolerance for retrieving irrelevant information and are increasingly expecting to be served with personalized information that meets their needs and preference. Personalized environments are of many advantages to applications such as e-commerce and research due to their need to provide the best possible results to the users as fast as possible. Personalized web environments that customize search results to specific users based on their behavior and preference while searching are becoming increasingly popular to solve this problem. Short-term and long-term user preferences are constructed from data on actions and top queries, visited content, and user preferences. Lots of websites already use this kind of personalized search, and it's making a big difference in how people use the internet
Study of Aerial Image Classification
Authors: Deulkar Vaishnavi , Kale Shashwat , Thakur Yashsingh , Bhagwat Prof. Anirudh
Published: April 2024

Abstract: Classifying images captured through remote sensing is necessary for various reasons, including monitoring the environment and assessing agriculture. The progress in thisfield has been greatly enhanced by the integration of advancements in machine learning, especially deep learning, and also accessibility of high-definition images obtained through remote sensing. CNNs are now necessary instruments for precise recognition and classificationof objects in aerial imaging. These models use convolution and pooling operations to capture local patterns and relationships, enhancing image classification accuracy. This review paper presents a comprehensive look at the most recent techniques for categorising remote sensing images. It emphasises the significance of accurate classification in the constantly evolving contemporary society and investigates new progress made possible by deep learning methods.The article explores problems in pinpointing unique and important areas in remote sensing images and illustrates how deep learning models tackle these problems through comprehendingrelationships among objects and other elements in the scene. The article assesses the advantagesand disadvantages of various techniques in relation to accuracy, computational efficiency, andscalability through a comparison between traditional methods and deep learning-based methods.
Optimizing Visual Sensor Node Image Compression for Resource-Constrained Environments
Authors: Balaji K.
Published: April 2024

Abstract: An Approximate hybrid multiplier design is proposed to reduce the data-path width of lifting 2-D discrete wavelet transform (DWT) especially for wireless visual sensor node applications. The proposed multiplier design takes multiplier operand of size less by 3 bit and calculates full-width outputs with marginal loss of accuracy, which is significant. The proposed approximate 2-D DWT structure uses data-path DWT levels and produces reconstructed color images higher than the 70-dB peak-signal-to-noise ratio (PSNR). Compared with the existing fractional wavelet transform (FrWT)-based 2D DWT structures, the proposed structure has a smaller data-path width and free from overhead. Compared with the existing parallel structure
Soil Fertility Detection For Crop Recommendation
Authors: A Pooja
Published: April 2024

Technological advances in agricultural process have changed from traditional methods to automated methods to achieve productive yield. Thus, suitable climatic and soil conditions are tested to maximize performance. Agricultural parameters are monitored to improvise the quality and quantity of agriculture. An important parameter is soil fertility, which is the proportion of nutrients in the soil necessary for cultivation. Determine the average percentage of essential nutrients (e.g. nitrogen, phosphorus, and potassium) and determine the appropriate crops for a given soil type. The proposed system analysis soil nutrient concentrations in real time and prepares a yield forecast. The system predicts humidity, humidity and temperature values based on historical data through sensors. Yield prediction involves many factors, including biological \properties, soil properties, and environmental conditions.
Governance for Azure and AWS Cloud Services
Authors: Abdelghany Ahmed , Gamal Mohamed , Aly Dr. Tarek , Gheith Prof. Dr. Mervat
Published: April 2024

Abstract: These days, cloud computing services are utilized in all business, academic, and governmental domains to build IT infrastructure. Cloud computing services are one IT solution that is becoming more and more popular among different types of enterprises. Cloud computing services face many challenges, like how to protect and raise user knowledge. These problems and difficulties also pertain to cloud computing services, which could result in a number of important risk areas. One of the problems is not being aware of the hazards associated with cloud computing services and the controls that are required to reduce these risks. Because governance is difficult to execute in the cloud computing environment and has the responsibility of assessing performance and adherence to predetermined goals and objectives, it hinders the adoption of cloud computing services. This study aims to develop a model that ensures that the required controls are applied in cloud services offered by Microsoft Azure and Amazon Web Services (AWS) and assesses the risk if the controls are not applied.
Entre o ensinar e o aprender: o PIBID UNILAB como agente de transformação da educação
Authors: Martins Elcimar Simão , Araújo Juliana Geórgia Gonçalves de , Nunes Reginaldo de Oliveira
Published: April 2024

O e-book “Entre o ensinar e o aprender: o Pibid Unilab como agente de transformação da educação” traz reflexões sobre o Programa Institucional de Bolsas para Iniciação à Docência (PIBID), que emerge como uma iniciativa para a Educação Brasileira, destacando-se não apenas pela sua relevância histórica, mas também por sua importância no contexto contemporâneo. Em um cenário onde a Educação continua sendo um campo necessário para a transformação social, o PIBID desempenha um papel central na formação inicial e continuada de educadores (as). No contexto atual, o PIBID assume um protagonismo ainda mais importante ao proporcionar a construção e realização de subprojetos que promovem o diálogo entre teoria e prática, aproximando os/as futuros/as professores/as da realidade da Educação Básica. Essa interação não apenas amplia as aprendizagens teóricas dos/as pibidianos/as, mas também fortalece os laços entre a universidade e comunidade, impulsionando estratégias de ensino, pesquisa e extensão mais contextualizadas e eficazes. Ao proporcionar um espaço de reflexão e colaboração, o programa instrui jovens professores/as em processo de formação a contribuírem de forma significativa para a melhoria do aprendizado dos/as estudantes, ao mesmo tempo em que oferece oportunidades de formação continuada aos/as docentes supervisores/as. Na UNILAB, o PIBID não apenas resiste, mas floresce em meio aos desafios, demonstrando sua importância, relevância e impacto positivo na formação de educadores/as e na qualidade da Educação Básica tanto no Brasil quanto nos países lusófonos. Que possamos continuar a reconhecer e valorizar o PIBID e seu potencial transformador. Esse reconhecimento pode ser percebido nos escritos pibidianos disponibilizados em cada capítulo dessa obra.
Dynamics of Islamic Theological Thought Development in the Classical Period
Authors: Zaini Muhammad , Fauziah Mira
Published: April 2024

The discourse surrounding the issue of classical Islamic theology that has developed so far is: First, that the emergence of schools in Islamic theology was predominantly due to political factors, even though if explored more deeply it turns out that differences in methods of thinking were the main factor; Second, there is an assumption that mutaqaddimin scholars understand theological verses in the Koran textually and do not understand them rationally, even though in reality many Muslim theologians interpret these theological verses rationally and freely. Based on these two issues, this article will reveal the dynamics of Islamic theological thinking of Islamic scholars in the classical period. The aim is to find the significance of the influence of the thinking activities of Muslim theologians during the classical period on the growth and development of Islamic theological thought and the birth of firqahs in Islamic theology during that period.
Celestial Flames: Rabi'ah Al-Adawiyah's Spiritual Journey Through Love
Authors: IT Suraiya
Published: April 2024

By referring to God as the Beloved, Rabi'ah al-Adawiah, the first Sufi woman, articulated the relationship with the Divine in a way that has come to be recognized as uniquely Sufi. The love described in the Pattern of Rabi'ah is thought to be pure love for God; the lover must walk along the route of love in order to remember God alone, not Hell or Paradise. When Rabi'ah speaks of "love," he means something more fundamental than something constrained by reward or hope. Her affection is truly lovely. The first woman to discuss the practicalities of Sufism in an approachable and comprehensible manner was Rabi'ah. The genuine embodiment of the relationship between a human being and God is found in Rabi'ah's love. She has contributed significantly to the growth of Sufism. I will explore Rabi'ah al-Adawiah's practice of love in this article. She was a follower of the Sufi Way, a mystical path within Islam. She will share stories of her efforts to witness truth in many realms, as well as her dreams and visions, as well as her sacred songs and poetry
CONSTRUÇÃO E VALIDAÇÃO DE UMA SEQUÊNCIA DIDÁTICA COM O TEMA QUEIMADAS BASEADA EM QUESTÕES SOCIOCIENTÍFICAS
Authors: Verdério Leonardo Álisson Pompermayer , Souza Leila Cristina Aoyama Barbosa
Published: April 2024

A proposta de sequência didática elaborada e validada neste estudo surge em decorrência do grande número de queimadas registradas no estado de Mato Grosso nos últimos anos. Tem por objetivos: a) construir e avaliar uma sequência didática sobre queimadas para os anos finais do Ensino Fundamental, baseada em fundamentos da educação Ciência-Tecnologia-Sociedade-Ambiente (CTSA) e Questões Sociocientíficas; e b) contribuir para a formação de professores de ciências e para a formação do pensamento crítico de estudantes sobre a prática de Queimadas. Metodologicamente, esta pesquisa, de abordagem qualitativa, caracteriza-se como bibliográfica e pesquisa de campo. A sequência didática foi elaborada com base nas dimensões do conteúdo (conceitual, procedimental e atitudinal), sendo composta por um caso sobre Queimadas, questões norteadoras para os encontros propostos e objetivos a serem trabalhados com os estudantes. Os professores que analisaram e validaram a sequência didática sinalizaram positivamente em relação ao potencial de exequibilidade da sequência, apresentando sugestões e contribuições para melhorar ainda mais a proposta didática. Espera-se que este estudo possa contribuir em processo do ensino de ciências contextualizado, visto que de um tema que faz parte da realidade dos estudantes e professores de Mato Grosso.
Inquisición, regalismo y reformismo borbónico. El Tribunal de la Inquisición de Logroño a finales del Antiguo Régimen
Authors: Torres Arce Marina
Published: April 2024

Estructurada en dos partes, la primera es un estudio institucional y burocrático del tribunal de distrito de Logroño, centrado en el análisis de su organización interna; en la segunda se establece la proyección social y política que obtuvo el tribunal en su entorno en el periodo final de su funcionamiento. Todo ello para responder a un doble objetivo: por un lado, aportar nuevos datos a la historiografía inquisitorial del siglo XVIII y, por otro, revisar los tópicos en los que ha estado sumida desde el siglo XIX, centrándonos en el periodo de 1746 a 1808 durante el cual se produjo el cambio de ideas que la Ilustración y el reformismo borbónico propiciaron y que acarreó la abolición de la Inquisición.
EXPERIENCES OF WORKPLACE BULLYING IN WOMEN WORKER
Authors: Oktaviana Mistety , Latiman Ari
Published: April 2024

This qualitative study aims to describe the experiences of Workplace Bullying in women worker. Workplace Bullying is an act of violence in the work environment, which involves verbal abuse, threats, ostracism, insults, isolation, eliminating opportunities, insinuating, giving harsh criticism, and interfering in other people's personal affairs. Workplace Bullying cause psychologically and physiologically problems. In this study, the subjects were 3 women who were still actively working at PT X. The interview technique used semi-structured using interview guidelines. The result of this study founds several themes and units of analysis, including factors that cause workplace bullying, who are the bullies, forms of workplace bullying, impacts that received by participants, the reasons why participants persist, the support they received, and about their hopes. It is hoped that this research can become a reference for policy makers to take preventive actions that can minimize the occurrence of workplace bullying.Keywords: workplace, bullying, women, worker
THE ROLE OF PSYCHOLOGICAL CAPITAL AND JOB RESOURCES ON WORK ENGAGEMENT AMONG GENERATION Z EMPLOYEES
Authors: Natalia Frinsca , Zamralita Zamralita , Lie Daniel
Published: April 2024

This study aimed to examine the role of psychological capital and job resources on work engagement among Generation Z employees. The number of samples in this study was 137 Generation Z employees at one of the companies dominated by Generation Z employees. This research used a non-experiment quantitative approach by using the Utrecht Work Engagement Scale, Psychological Capital Questionnaire, and Job Demands-Resources Questionnaire. Data were analyzed using simple linear regression. The results showed that psychological capital and job resources had a positive significant effect on work engagement. In this research, it is known that the psychological capital dimension that had the biggest impact on the work engagement of Generation Z employees is resilience. This research also found that the job resources dimension that had the biggest impact on the work engagement of Generation Z employees is feedback This study implied that psychological capital and job resources are two important tools to increase work engagement among Generation Z employees.
Characterization of Omalizumab Updosing Patterns and Predictive Factors in Chronic Spontaneous Urticaria : A Prospective Multicentric Observational Study.
Authors: PIERRARD Guillaume , Bernier Claire , DU-THANH AURELIE , BARA Corina , Soria Angele , Castelain Florence , Boccon-Gibod Isabelle , Hacard Florence , DELAUNAY Juliette , Montjoye Laurence De , STAUMONT-SALLE Delphine , Dezoteux Frédéric
Published: April 2024

Background: Limited information is available on the use of
omalizumab (OMA) updosing since its introduction as a second-line
therapy in chronic spontaneous urticaria (CSU) in 2014. Practical
guidelines from health authorities are lacking, and the specific
characteristics of patients requiring higher doses remain unknown. Our
objectives were to characterize the patterns of OMA updosing (defined as
changes in dose and/or injection intervals), to identify the predictive
factors associated with updosing, and to improve CSU management.
Methods: We conducted a prospective, multicentric, real-life,
observational study, including patients diagnosed with CSU and starting
OMA. The data were collected at 0, 3, 6 and 9 months. The primary
endpoint was the frequency of OMA updosing at 3 months. The secondary
endpoints included an analysis of updosed patients’ profile, and an
assessment of OMA efficacy and safety. Results: We included 153
patients. Twenty percent of patients at M3 were updosed, and 27% in
total during the 9-month follow-up. Practitioners mainly chose to
increase the frequency of injections (66%). At baseline, the updosed
patients were more likely, to have inducible urticaria (50% vs. 33%,
p=0.046), more severe CSU (UCT 3 vs. 4, p<0.001; DLQI 14 vs.
11, p=0.040), a lower lymphocyte count (1894 vs. 2100, p=0.026) and IgE
below 70 UI/mL (65% vs. 45%, p=0.039). The side effects of OMA were
not more frequent after updosing. Conclusion: One in five
patient underwent updosing within just three months. OMA updosing is
frequent in particular in cases of severe disease, inducible urticaria
and low IgE blood levels.
Philosophical tools to understand conceptual development in neuroscience
Authors: Haueis Philipp , Daniel Margulies
Published: April 2024

Alongside models and methods, concepts are one of the building blocks of
neuroscientific inquiry. They help researchers to pursue various goals,
such as describing novel patterns in the data, situate these patterns in
existing models, formulate new models or build explanations, e.g., of
how the brain processes sensory information. Often the formation of
novel or reinterpretation of existing concepts can signal major shifts
in how we understand the brain and investigate it scientifically. Yet
not every novel concept or reinterpretation produces such a shift, which
raises the question of when concepts succeed or fail to change our
understanding of the brain. In this paper, we introduce analytical tools
developed by philosophers of science and concepts of brain organization
as examples to discuss when introducing novel, reinterpreting existing
and replacing outdated neuroscientific concepts succeeds or fails. Our
discussion opens up novel avenues for neuroscientists and philosophers
to collaborate around the limits of old and prospects of new concepts
describing how the brain is organized.
Surface Quasi Geostrophic Reconstruction of Vertical Velocities and Vertical Heat Fluxes in the Southern Ocean: Perspectives for SWOT
Authors: Carli Elisa , Siegelman Lia , Morrow Rosemary Anne , Vergara Oscar
Published: April 2024

Mesoscale currents account for 80% of the ocean’s kinetic energy,
whereas submesoscale currents capture 50% of the vertical velocity
variance.SWOT’s first sea surface height (SSH) observations have a spatial
resolution an order of magnitude greater than traditional nadir-looking
altimeters and capture mesoscale and submesoscale features. This enables
the derivation of submesoscale vertical velocities, crucial for the
vertical transport of heat, carbon and nutrients between the ocean
interior and the surface.This work focuses on a mesoscale energetic region south of Tasmania
using a coupled ocean-atmosphere simulation at km-scale resolution and
preliminary SWOT SSH observations. Vertical velocities (w), temperature
anomalies and vertical heat fluxes (VHF) from the surface down to 1000 m
are reconstructed using effective surface Quasi-Geostrophic (sQG)
theory. An independent method for reconstructing temperature anomalies,
mimicking an operational gridded product, is also developed. Results
show that sQG reconstructs 90% of the total \textit{w}
and VHF rms at scales down to 30 km just below the mixed layer and
50-70% of the rms for scales larger than 70 km at greater depth, with a
spatial correlation of ~0.6. The reconstruction is
spectrally coherent (>0.65) for scales larger than 30-40 km
at the surface, slightly degrading (~0.55) at depth.The two temperature anomalies datasets yield similar results, indicating
the dominance of w on VHF.RMS of sQG w and VHF derived from SWOT are twice as large as those
derived from conventional altimetry, highlighting the potential of SWOT
for reconstructing energetic meso and submesoscale dynamics in the ocean
interior.
Sharp bounds on Hankel determinants of bounded turning functions involving the hyperbolic tangent function
Authors: Wang Zhi-Gang , Srivastava H.M. , Arif M. , Liu Zhi-Hong , Ullah K.
Published: April 2024

In this paper, we determine the sharp upper bounds of Hankel determinants for
logarithmic and inverse functions of bounded turning functions associated
with the hyperbolic tangent function.
Effects of transpalatal arch wire dimension and temporary skeletal anchorage device position on maxillary molar intrusion
Authors: Wang Xiaoting , Zhao Yichen , Fan Mingyue , Zhou Ting , Fang Bing , Ye Niansong
Published: April 2024

Objectives

To investigate the effects of transpalatal (TPA) wire dimension and temporary skeletal anchorage device (TSAD) position on maxillary molar intrusion.

Materials and Methods

The maxillary molar intrusion measurement system included a maxillary acrylic model, TPA, TSADs, and a three-dimensional Force/Moment (F/M) sensor. The intrusion patterns were categorized into six groups: buccal-mesial, buccal-distal, buccal-mesiodistal, palatal-mesial, palatal-distal, and palatal-mesiodistal. TPA wire dimensions were designed to be 0.7 mm, 0.9 mm, and 1.2 mm. The force and moment loads of the maxillary first molar were measured by the F/M sensor.

Results

Single buccal or palatal TSADs induced torquing movement, and single mesial or distal TSADs tended to promote tipping movement. Mesiodistal TSADs would have eliminated tipping, but accentuated torquing movement. The TPA significantly reduced the force and moment experienced by the maxillary first molar along three-dimensional axes. The thicker the TPA wire, the smaller the force and moment to which the maxillary first molar was subjected.

Conclusions

Precise placement of TSADs might have a substantial influence on tooth movement and should be determined in accordance with specific clinical requirements. Increasing the TPA wire dimension could diminish the tipping, torquing, and rotation during TSAD-assisted maxillary molar intrusion, but these tendencies could not be completely eliminated.
Increased cancer incidence among patients with hidradenitis suppurativa – a Danish nationwide register study 1977–2017
Authors: Andersen Rune , Rostgaard Klaus , Pedersen Ole , Jemec Gregor Borut Ernst , Hjalgrim Henrik
Published: April 2024

Background: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%–1%, diagnostic delay: 7–10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce.
Materials and methods: A nationwide retrospective register-based study assessing relative risk of cancer – overall and by anatomical site – following HS diagnosis expressed as standardized incidence ratios (SIRs), which is ratios between observed cases among all Danes diagnosed with HS since 1977 and expected cases based on cancer incidence rates of the entire Danish population during the same period.
Results: Participants consisted of a cohort of 13,919 Danes with HS, who during an average of 14.2 years of follow-up developed a total of 1,193 incident cancers, corresponding to a 40% increased risk (SIR = 1.4, 95% CI: 1.3 to 1.4, p < 0.001). Increased risks were observed for cancers of the respiratory system, oral cavity and pharynx, digestive organs and peritoneum, urinary tract, and the lymphatic tissues.
Interpretation: These findings underline an unmet need for health monitoring, lifestyle interventions and cancer screening if and when relevant.
Pandemi Sonrası İlkokul Öğrenci Davranışları Hakkında Sınıf Öğretmenlerinin Görüşleri
Authors: Karaca Abdurrahman , Özenç Emine Gül
Published: April 2024

Bu araştırma pandemi sonrasında ilkokul öğrencilerinin davranışları ile ilgili sınıf öğretmenlerinin görüşlerini belirlemek amacıyla yapılmıştır. Araştırma, 2021-2022 eğitim öğretim yılı başında yüz yüze eğitimin tam zamanlı olarak başlaması ile Niğde ili Bor ilçe merkezindeki okullarda görev yapan 20 sınıf öğretmeni ile gerçekleştirilmiştir. Araştırma, nitel bir çalışma olup öğretmenlerin algı ve deneyimlerini rahatça ortaya koyabilmeleri için fenomonolojik yaklaşımla yürütülmüştür. Araştırmanın çalışma grubunu 1-4. sınıflarda derse giren sınıf öğretmenleri oluşturmaktadır. Elde edilen veriler içerik analizi yöntemi kullanılarak, yarı yapılandırılmış görüşme formu ile sağlanmıştır. Bulgular sonucunda; bu süreçte öğrencilerin okul kültüründen uzaklaştıkları ve hareketli davranışlarında da artış olduğu görülmüştür. Ayrıca öğrencilerin kendilerini göstermek istedikleri ve sosyalleşme arayışı içine girdikleri de tespit edilmiştir.
Kutup Farkındalık Ölçeği nin (KFÖ) Geliştirilmesi: Geçerlik ve Güvenirlik Çalışması
Authors: Tuti Gamze , Ursavaş Nazihan , Mavi Duran , Çolak-Seymen Canan , Selçuk Volkan , Kandemir Raif
Published: April 2024

Dünyanın iki uç bölgesini oluşturan kutuplar, büyük çoğunluğu buzla kaplı olup iklim değişikliğinden etkilenmesi beklenen önemli alanlardandır. Kutuplardaki buzulların erimesi yalnızca bu bölgeleri değil, tüm dünyayı yakından ilgilendiren küresel bir sorundur. Bu bölgeler hakkında yeterli farkındalığın oluşturulması gelecekte karşılaşılacak sorunlara karşı önlem almada önemli görülmektedir. Bu bağlamda bireylerin farkındalıklarının belirlenmesinde ölçek geliştirme çalışmalarının geniş kitlelerin düzeylerinin belirlenmesinde önemli bir yere sahip olduğu da bilinmektedir. Mevcut çalışmada liselerde öğrenim gören öğrencilerin kutuplar ve kutuplar hakkındaki farkındalık düzeylerini belirlemeye yönelik bir ölçme aracının geliştirilmesi amaçlanmıştır. Nicel araştırma yaklaşımlarından tarama yöntemine göre desenlenen çalışmanın örneklemini 2021-2022 eğitim öğretim yılında Türkiye’nin kuzeydoğusunda yer alan bir ilin merkezi ilçelerinden birinde öğrenim gören lise öğrencileri oluşturmaktadır. Öğrencilerin seçiminde maksimum çeşitlilik örnekleme yöntemi kullanılmış olup, birinci merhale için 300, ikinci merhale için 307 olmak üzere toplam 607 öğrenci ile çalışılmıştır. Analiz sürecinde madde analizi, açımlayıcı faktör analizi, doğrulayıcı faktör analizi uygulanmış ve devamında güvenirlik katsayıları hesaplanmıştır. Gerçekleştirilen analiz sonucu altı alt boyuttan oluşan toplam 17 maddeli kabul edilebilir bir uyuma sahip bir ölçek elde edilmiştir. Bu bulgulara göre, Kutup Farkındalık Ölçeği (KFÖ)’nin öğrencilerin kutuplara ilişkin farkındalıklarını ölçmek amacıyla kullanılabilecek geçerli ve güvenilir bir ölçme aracı olduğu ifade edilebilir.
The Efficiency of Biological Treatment Plants in Some Private Hospitals in the City of Basra, Iraq
Authors: DA Al-Abbawy
Published: April 2024

This study aimed revealing the qualitative characteristics of medical wastewater in large health institutions and its potential effects on freshwater rivers. Due to the lack of studies in this field, the research focused on the current treatment reality in two private hospitals, Al-Saadi and Al-Mawaddah. The objectives were to assess the liquid waste management, detect the efficiency of treatment units, evaluate the handling of liquid medical waste on fresh waterways, and compare the results with the required treatment levels. The study analyzed water properties from the sewage systems of the targeted hospitals. Samples were collected in 2022 from direct sources of discharged water and the treatment plant before mixing with public sewage. Physical, chemical, and biological characteristics, including pH, suspended solids, oxygen demand, nitrates, and phosphates, were measured before and after treatment. The highest removal efficiency was observed in the chemical and biological oxygen demand values, recorded at 83.73% and 84.39% for Al-Saadi Hospital, and 89.99% and 87.89% for Al-Mawaddah Hospital.
Model Pembelajaran Berbasis Karakter Konservasi untuk Anak Kelompok B Taman Kanak-Kanak
Authors: Nisa Fitriyan , Agung Anak Agung Gede
Published: April 2024

Penelitian ini bertujuan untuk mendeskripsikan peroses pengembangan model pembelajaran berbasis karakter konservasi dan mengetahui hasil validitas model pembelajaran berbasis karakter konservasi yang layak digunakan sebagai pedoman pembelajaran untuk anak kelompok B Kabupaten Buleleng Tahun Pelajaran 2020-2021. Jenis penelitian ini adalah penelitian pengembangan, prosedur penelitian pengembangan menggunakan model ADDIE yaitu: tahap analisis, desain, pengembangan, implementasi, dan evaluasi. Penelitian ini diawali dengan menganalisis kebutuhan, kemudian merancang model pembelajaran berbasis karakter konservasi sehingga menjadi model pembelajaran berbasis karakter konservasi yang utuh. Penelitian ini melibatkan siswa kelompok B Kabupaten Buleleng Tahun Ajaran 2020/2021. Data validitas uji ahli isi pembelajaran dan uji perorangan diperoleh dengan menggunakan angket. Data hasil penelitian dianalisis dengan teknik deskriftif kualitatif dan kuantitatif. Hasil penilaian menemukan bahwa (1) hasil uji ahli isi diperoleh persentase skor 83,70% dengan kualifikasi baik, (2) persentase skor hasil uji perorangan 85.66% dengan kualifikasi sangat baik. Berdasarkan hasil tersebut dapat disimpulkan bahwa model pembelajaran ini dinilai layak digunakan dalam pembelajaran di TK Tunas Harapan Maju Kabupaten Buleleng Tahun Pelajaran 2020/2021.
Kecerdasan Emosional dan Supervisi Kepala Sekolah Berpengaruh Terhadap Disiplin Kerja Guru Sekolah Dasar
Authors: Karmini Ni Kadek Ayu , Suniasih Ni Wayan
Published: April 2024

Upaya peningkatan kualitas pendidikan dipengaruhi oleh tingkat kedisiplinan dan profesionalitas guru dalam pelaksanaan tugas pokok dan fungsinya di sekolah. Upaya untuk meningkatkan kualitas guru masih belum maksimal terwujud, hal ini dilihat dari banyaknya guru yang masih melakukan pelanggaran disiplin kerja yang bisa ditemui di media elektronik, media cetak maupun di lapangan. Tujuan penelitian ini untuk menganalisis pengaruh kecerdasan emosional dan supervisi kepala sekolah terhadap disiplin kerja guru. Penelitian ini menggunakan rancangan ex post facto dengan studi pendekatan korelasional. Populasi dalam penelitian ini adalah guru-guru yang berjumlah 70 orang. Sampel pada penelitian menggunakan teknik sampling total yaitu semua anggota populasi menjadi sampel. Metode pengumpulan data yang digunakan adalah metode non tes, yaitu angket. Data dianalisis menggunakan analisis regresi linier sederhana dan analisis regresi linier ganda. Berdasarkan hasil analisis yang dilakukan maka, (1) terdapat pengaruh yang signifikan kecerdasan emosional terhadap disiplin kerja guru berdasarkan Fhitung = 26,798 > Ftabel = 3,98 dengan kontribusi sebesar 10,45%, (2) terdapat pengaruh yang signifikan supervisi kepala sekolah terhadap disiplin kerja guru berdasarkan Fhitung = 30,836 > Ftabel = 3,98  dengan kontribusinya sebesar 21,75%, dan (3) terdapat pengaruh yang signifikan kecerdasan emosional dan supervisi kepala sekolah terhadap disiplin kerja guru berdasarkan 15,910 > dan 3,13 dengan kontribusinya sebesar 32,20%. Sehingga dapat disimpulkan bahwa terdapat pengaruh yang signifikan kecerdasan emosional dan supervisi kepala sekolah terhadap disiplin kerja guru dengan kontribusi sebesar 32,20%, maka terdapat faktor lain yang mempengaruhi disiplin kerja guru selain kecerdasan emosional dan supervisi kepala sekolah. Implikasi penelitian ini dapat dijadikan sebagai referensi bagi peneliti lain.