bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor-Agnostic Drug Development
Authors: Offin Michael , Liu Dazhi , Drilon Alexander
Published: June 2018

Therapies designed to target cancers that harbor specific molecular signatures have reshaped the landscape of oncologic drug development, and advances in next generation sequencing have led to an increase in the identification of these alterations across tumor types. Tumor-agnostic trial designs, such as the “basket trial,” have been developed as an approach to study the efficacy of these treatments and increase patient access, especially for patients whose tumors carry these alterations infrequently. We review key aspects of these genomically enriched trial strategies and their impact on drug development and approval.
Incorporating Biology Into Breast Cancer Staging: American Joint Committee on Cancer, Eighth Edition, Revisions and Beyond
Authors: Mittendorf Elizabeth A. , Bartlett John M. S. , Lichtensztajn Daphne L. , Chandarlapaty Sarat
Published: June 2018

Higher-quality imaging, refined surgical procedures, enhanced pathologic evaluation, and improved understanding of the impact of tumor biology on treatment and prognosis have necessitated revisions of the AJCC breast cancer staging system. The eighth edition includes clinical and pathologic prognostic stages that incorporate biologic variables—grade, estrogen and progesterone receptor status, HER2 status, and multigene panels—with the anatomic extent of disease defined by tumor, node, and metastasis categories. The prognostic staging systems facilitate more refined stratification with respect to survival than anatomic stage alone. Because the prognostic staging systems are dependent on biologic factors, accuracy is dependent on rigorous pathologic evaluation of tumors and on administration of treatment dictated by tumor biology. It is anticipated that technological advances will facilitate even more refined determination of underlying biology within tumors and in the peripheral blood, which increasingly is being evaluated as a compartment that reflects the primary tumor and sites of distant metastases. Diseases should be staged according to the eighth edition staging system to accurately reflect prognosis and to allow standardized data collection. Such standardization will facilitate assessment of the impact of advances in diagnosis and treatment of patients with breast cancer.
Integrating Genomics Into Neuro-Oncology Clinical Trials and Practice
Authors: Galanis Evanthia , Nassiri Farhad , Coy Shannon , Nejad Romina , Zadeh Gelareh , Santagata Sandro
Published: June 2018

Important advances in our understanding of the molecular biology of brain tumors have resulted in a rapid evolution in the taxonomy of central nervous system (CNS) tumors, which culminated in the revised 2016 World Health Organization classification of CNS tumors that incorporates an integrated molecular/histologic diagnostic approach. Our expanding understanding of brain tumor genomics and molecular evolution during the disease course has started to impact clinical management. Furthermore, incorporation of genomic information in ongoing and planned neuro-oncology clinical trials is expected to lead to improved outcomes and result in personalized treatment options for patients with CNS malignancies.
Management of Refractory Germ Cell Cancer
Authors: Lorch Anja
Published: June 2018

Over the past 5 decades, the use of well-validated, guideline-based strategies has resulted in high cure rates in newly diagnosed patients with germ cell cancer. However, about 30% of those with metastatic disease at initial presentation will experience refractory disease. Salvage treatment is far more complex and less validated than first-line treatment because it is rare, patient cohorts are more heterogeneous, and prognostic factors seem to have greater impact. Prior to the initiation of any salvage treatment, several considerations must be made, including assessment of known prognostic factors and choice of the optimal salvage strategy. Evaluation of patients according to their disease biology, response to prior treatment, and the extent of their tumor burden at the time of salvage treatment is crucial for establishing the optimal salvage strategy. Patients with metastatic germ cell cancer in whom adequate cisplatin-based first-line chemotherapy fails should be included in the ongoing randomized TIGER trial comparing conventional-dose chemotherapy with high-dose chemotherapy as first salvage treatment. Outside this trial, patients may be treated with conventional or high-dose chemotherapy depending on the presence or absence of adverse prognostic factors, availability of resources, and patient and physician preferences.
Personalized Management of Advanced Kidney Cancer
Authors: Graham Jeffrey , Heng Daniel Y. C. , Brugarolas James , Vaishampayan Ulka
Published: June 2018

The treatment of renal cell carcinoma represents one of the great success stories in translational cancer research, with the development of novel therapies targeting key oncogenic pathways. These include drugs that target the VEGF and mTOR pathways, as well as novel immuno-oncology agents. Despite the therapeutic advancements, there is a paucity of well-validated prognostic and predictive biomarkers in advanced kidney cancer. With a number of highly effective therapies available across multiple lines, it will become increasingly important to develop a more tailored approach to treatment selection. Prognostic clinical models, such the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model, are routinely used for prognostication in clinical practice. The IMDC model has demonstrated a predictive capability in the context of these treatments including immune checkpoint inhibition. A number of promising molecular markers and gene expression signatures are being explored as prognostic and predictive biomarkers, but none are ready to be widely used for treatment selection. In this review, we will explore the current landscape of personalized care in metastatic renal cell carcinoma. This will include a focus on both prognostic and predictive factors as well as clinical applications of biology in kidney cancer.
Multidisciplinary Management of Muscle-Invasive Bladder Cancer: Current Challenges and Future Directions
Authors: Aragon-Ching Jeanny B. , Werntz Ryan P. , Zietman Anthony L. , Steinberg Gary D.
Published: June 2018

The treatment of muscle-invasive bladder cancer (MIBC) is complex and requires a multidisciplinary collaboration among surgery, radiation, and medical oncology. Although neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) and lymph node dissection has been considered the standard treatment for MIBC, many patients are unfit for surgery or cisplatin-ineligible, and considerations for bladder-preservation strategies not only are increasingly recognized as optimal treatment alternatives, but also should feature in the range of management options presented to patients at the time of diagnosis. Apart from chemotherapy, immunotherapy has also been used with success in locally advanced and metastatic bladder cancer and is moving into the MIBC space. Prospective studies addressing trends in management that span systemic, surgical, and radiation options for patients are discussed in this article.
The Winds of Change: Emerging Therapeutics in Prostate Cancer
Authors: Pezaro Carmel J. , Marciscano Ariel E. , Madan Ravi A.
Published: June 2018

The last decade has seen substantial advances in androgen receptor targeting in prostate cancer. In addition, advances have been made in immunotherapy and radiopharmaceutical-based therapy, although their optimal use in the clinic remains unclear. Recent understanding of the relevance and actionability of DNA damage repair mutations in a considerable minority of patients with prostate cancer is likely to open up a new frontier in prostate cancer therapeutics. As androgen receptor–directed therapy moves earlier in the disease process for prostate cancer, advances in these nonandrogen receptor–based therapeutics may take on greater significance in the years to come.
Addressing the Unintentional Consequences of Cancer Therapy With Novel Integrative Therapeutics
Authors: Bao Ting , Peppone Luke J. , Robinson Patricia
Published: June 2018

There are 15.5 million cancer survivors in the United States because of, in part, improvements in therapy. As a result, there will be an increased burden of long- and late-term complications of cancer care, such as metabolic alterations. These metabolic changes will include alterations in bone resorption, obesity, hypercholesterolemia, and diabetes mellitus. The majority of cancer treatment–related toxicities have focused on endocrine therapy; however, chemotherapy and supportive medications, such as steroids, contribute to the development of these disorders. Because of the chronicity of these metabolic changes and their impact on morbidity, cancer risk, and outcomes as well other negative effects, including musculoskeletal pain and vasomotor symptoms, alternative strategies must be developed. These strategies should include nonpharmacologic approaches. Here, we summarize metabolic changes secondary to cancer care and integrative approaches to help alleviate therapy-associated toxicities.
Tumor Response Assessment for Precision Cancer Therapy: Response Evaluation Criteria in Solid Tumors and Beyond
Authors: Nishino Mizuki
Published: June 2018

Objective assessment of tumor responses and treatment results has been the basis for the advancement of cancer therapies, and imaging plays a key role to provide a “common language” to describe the results of cancer treatment. Although Response Evaluation Criteria in Solid Tumors (RECIST) has been the most widely accepted method for assessing tumor response in the past decades, the limitations of RECIST have increasingly becoming recognized, especially with the recent advances of precision-medicine approaches to cancer. This article reviews the current concept of tumor response evaluations based on RECIST, describes the limitations of RECIST, and proposes strategies to overcome the limitations. The article emphasizes specific limitations in the setting of precision cancer therapy and cancer immunotherapy and discusses the important insights provided by the cutting-edge investigations in the emerging fields.
Caring for Colleagues and Loved Ones With Cancer
Authors: Cook John W. , Dillmon Melissa , Graff Stephanie L. , Pentz Rebecca D. , Srivastava Ranjana , Close Julia L.
Published: June 2018

Throughout the arc of a career in medicine, physicians are universally faced with the difficult decision of when to provide care for a colleague and when to refer to another physician. Gauging the magnitude of your relationship, both professionally and personally, and then weighing how to add the roles of physician and patient to your preexisting relationship is complex. We review and discuss care of family and colleagues, address ethical boundaries both firm and flexible, and explore the emotional weight of those relationships.
Pain Management in the Era of the Opioid Crisis
Authors: Bruera Eduardo , Del Fabbro Egidio
Published: June 2018

PRACTICAL APPLICATIONS

Recognize patients at higher risk for nonmedical opioid use. Learn about screening for chemical coping risk. Diagnose nonmedical opioid use. Manage nonmedical opioid use in the clinical oncology setting. Understand clinical criteria for referral to supportive and palliative care teams.
Precision Medicine in Non–Small Cell Lung Cancer: Current Standards in Pathology and Biomarker Interpretation
Authors: Brown Noah A. , Aisner Dara L. , Oxnard Geoffrey R.
Published: June 2018

Non–small cell lung cancer (NSCLC) has become a prominent example of precision medicine among solid tumor malignancies. Clinical management of NSCLC now depends on surgical, chemotherapeutic, and radiation treatment regimens based on pathologic findings and clinical staging as well as targeted therapies based on molecular profiling. As molecular testing becomes increasingly important, preserving tissue for this purpose while rendering an accurate histologic diagnosis becomes a key consideration, particularly in advanced-stage NSCLC, in which small biopsy samples or aspirates are often the only specimen available. Next-generation sequencing panels are a powerful method of providing information relevant for both standard-of-care and investigational treatment options. However, taking advantage of the abundance of information gleaned from these panels requires careful annotation, prioritization, and reporting of molecular findings and their clinical significance. Although molecular profiling has traditionally relied on direct sampling of neoplastic tissue, blood-based diagnostics now offer the potential to provide some clinically useful information noninvasively.
So Much Data, So Little Knowledge: Using Formal Logic to Aggregate Data and Interpret Information
Authors: Hoverman J. Russell
Published: June 2018

Formal logic is the use of symbols to structure how we make inferences such that the structure can be applied beyond specific cases. The structure of clinical trials and the values equation (value = outcomes/cost) lend themselves to evaluation using formal logic. Doing this demonstrates the unique position of randomized clinical trials as a defensible format for gathering information and identifies the shortcomings of historical controls and meta-analyses and retrospective studies using large databases. A practical example using literature on maintenance therapy in metastatic colorectal cancer is assessed. It is important to emphasize that value will be relative to a viewpoint, with many interested parties having competing values. This underscores the place of physicians and professional societies as putting patient values first.
Wnt signaling in development and tissue homeostasis
Authors: Steinhart Zachary , Angers Stephane
Published: June 2018

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.
LATE MIOCENE CALCAREOUS NANNOFOSSIL STRATIGRAPHY AND BIOEVENTS CORRELATION: KALIDONIA CASE SECTION (NW CRETE, GREECE)
Authors: Bellas S. , Frydas D. , Keupp H.
Published: June 2018

Calcareous nannofossils are widely used for biostratigraphic correlations. Quantitative approaches enable better understanding of reliability of bioevents. In order to refine the late Miocene stratigraphy ofNW Crete, the deposits of Kalidonia basin along its type section are here investigated. It was possible to distinguish the Tortonian/Messinian boundary by NNlla & NNllb, CN9a & CN9b, MNNlla & MNNllb biozones. Reticulofenestra pseudoumbilicus PB (Paracme Beginning) and R. rotaria FO (First Occurrence) proved to act as additional significant biohorizons improving the stratigraphie evolution of the studied paleobasin and providing a tight biochronologic framework. The Kalidonia section fully covers an undisturbed marine depositional cycle from the upper Tortonian to upper Messinian, where a predominant deep water fades (DWF) is followed by transitional sediments (TF) and the sequence closes at the top by a reefal-bioclastic fades (RF) relative to the 'Calcare di Base ' in Italy indicating the 'Messinian Salinity Crisis Event.
PALAEONTOLOGICAL (RADIOLARIAN) LATE JURASSIC AGE CONSTRAINT FOR THE STEPANAVAN OPHIOLITE (LESSER CAUCASUS, ARMENIA)
Authors: Danelian T. , Galoyan G. , Rolland Y. , Sosson M.
Published: June 2018

Micropalaeontological age evidence for the sedimentary cover of ophiolites is important to understand the palaeogeographic and geodynamic evolution of Tethyan realms. The Stepanavan ophiolitic suite of Northern Armenia consists of peridotites, gabbros, plagiogranite and lavas with a radiolarite sedimentary cover. It is regarded as the northern extension of the Sevan Akera ophiolitic zone and may be considered as the eastern extension of the Izmir-Ankara suture zone. It represents the relics of a slow-spreading mid oceanic ridge that was active between Eurasia and the South-Armenian Block of Gondwanian origin. Radiolaria extracted from radiolarites of the Stepanavan ophiolite provide for the first time a Late Jurassic (late Kimmeridgian to early Tithonian) age constraint for this part of Tethyan oceanic crust preserved in Lesser Caucasus.
A DEBATE ON THE SIMILARITY OF PARTICLE SIZING RESULTS DERIVED FROM THE ANALYSIS OF FINEGRAINED SEDIMENTS BY TWO DIFFERENT INSTRUMENTATIONS
Authors: Iatrou M. , Papatheodorou G. , Piper D. J.W. , Tripsanas E. , Ferentinos G.
Published: June 2018

A set of grab-sample sediments collected from the basin floor of the Corinth Gulf, Greece, was analysed using two different techniques; LS 230 laser system and Coulter Counter TA II. The present study presents the results derived from the comparison between the two techniques. The correlation between the mean size and the sorting values obtained from the two methods is moderate. Also moderate are the correlations estimated for the fractions of clay and silt obtained from the two methods Furthermore the analysis showed that the Laser Coulter determines coarser grain sizes than the Coulter. The analysis of variation/residuals within individual size intervals showed a higher variability of residuals for the coarser fractions (7-6 and 5-4 phi).
REGIONAL CORRELATION AND CYCLOSTRATIGRAPHY IN THE MID-CRETACEOUS FORMATIONS OF THE IONIAN ZONE
Authors: Karakitsios V. , Agiadi-Katsiaouni K.
Published: June 2018

The mid-Cretaceous period is characterized by the widespread deposition of organic carbon-rich horizons, documenting oceanic anoxic events (OAEs), which correspond to episodes of major disturbances in the carbon cycle. The causes of these events are still widely debated. In this study, the role of orbital variations in the deposition of black shales in the Ionian Zone (Western Greece), an area already known for documenting OAEs is examined. Cyclostratigraphic data for the Lower Aptian interval are interpreted in a climate change context, and specific mechanisms for the deposition of organic carbon-rich horizons are hypothesized. Field observations, stable isotope and total organic carbon analyses, as well as biostratigraphic data enable a correlation between the Gotzikas section and the Paliambella section, also in the Ionian Zone (Epirus, Greece). In addition, Gotzikas section is also correlated with the Poggio le Guaine - Fiume Bosso composite sequence of the Umbria - Marche region (Italy). Lower Aptian sedimentation in the Ionian Basin seems to be controlled by orbital forcing. The short eccentricity and obliquity rhythms are most prominently recorded. Whilst the presence of amplitude modulation cycles indicates towards a lesser control by the long eccentricity and precession periodicities.
APPLICATION OF BED THICKNESS DISTRIBUTIONS IN TURBIDITE DEPOSITS OF LEMNOS ISLAND, NE GREECE
Authors: Maravelis A. , Konstantopoulos P. , Pantopoulos G. , Zelilidis A.
Published: June 2018

The submarine fan deposits in Lemnos Island, of the NE Greece provide a perfect opportunity to investigate the influence of processes such as erosion and bed amalgamation in the alternation of the shape of a power-law cumulative frequency distribution. The bed thickness distribution in two outcrops of late Eocene to early Oligocene turbidite deposits that correspond to different sub-environment, has been assessed statistically. Sediments of the outcrop 1 at the SE parts of the Lemnos Island interpreted as outer fan deposits and sediments of the outcrop 2 located at the NE parts of the island as inner fan deposits show both a good fit to the power-law, amplifying the hypothesis that departures from power-law statistics might be used as evidence of erosion and bed amalgamation. The main difference between these two outcrops is that the power law exponent decreases abruptly from outcrop 1 to outcrop 2, confirming with the aspect that the power law exponent can be considered as a good indicator for the available sedimentary space.
THE MORPHONEOTECTONIC STRUCTURE OF THE TRANSITIONAL ZONE BETWEEN THE GORTYNIA MT. HORST AND THE PYRGOS-OLYMPIA BASIN (CENTRAL -WESTERN PELOPONNESE, GREECE)
Authors: Fountoulis I. , Mavroulis S. , Theocharis D.
Published: June 2018

The present paper aims to the understanding of the neotectonic deformation in areas where no post-alpine sediment occurs. The study area is located at the transitional zone between the horst ofGortynia Mt. (Arcadia) and the Pyrgos-Olympia basin in the central-western Péloponnèse and is tectonically and seismically active. The studied neotectonic faults can be distinguished in low to mid angle faults and high angle faults. The majority of them present striation sets with significant horizontal component that causes the change in the direction and plunge of the fold axes of Pindos unit. The younger and with more active characteristics fault zones are the Lefkohori and Ohthia ones
Parasites affect hemocyte functionality in the hemolymph of the invasive Atlantic blue crab Callinectes sapidus from a coastal habitat of the Salento Peninsula (SE Italy)
Authors: PAGLIARA PATRIZIA , MANCINELLI GIORGIO
Published: June 2018

The blue crab Callinectes sapidus is an invasive alien species in the Mediterranean Sea. In native habitats, it is subjected to mortalities determined by different pathogens, including the dinoflagellate Hematodinium perezi, a parasite also affecting other brachyuran species. Specifically, Hematodinium-associated disease is acknowledged worldwide as an emerging infection for commercially important crustacean species, but the general diffusion in wild species is unknown. Here, a preliminary screening in C. sapidus hemolymph as well as in three indigenous crabs captured in SE Italy, evidenced the presence of unidentified protozoans in more than 70% of specimen, but the number of suspected Hematodinium cells was very low. The parasites occurrence affected C. sapidus hemocytes functionality, interfering with their role in innate immunity (i.e. phagocytosis or DOPA production). More studies are necessary in order to verify the impact of this alien brachyuran on invaded ecosystems as mediated by the spread of parasites and other pathogens.
Molluscs collected with otter trawl in the northern Alboran Sea: main assemblages, spatial distribution and environmental linkage
Authors: CIÉRCOLES CRISTINA , GARCÍA-RUIZ CRISTINA , GONZÁLEZ AGUILAR MARIA , ORTIZ DE URBINA GUTIERREZ JOSÉ M. , LÓPEZ-GONZÁLEZ NIEVES MARIA , URRA RECUERO JAVIER , RUEDA RUIZ JOSE LUIS
Published: June 2018

Molluscan assemblages of circalittoral and bathyal soft bottoms of the northern Alboran Sea were studied using an experimental otter trawl. Samples of fauna were collected from 190 hauls during four MEDITS surveys carried out in spring between 2012 and 2015 at depths ranging from 30 to 800 m. Measurements of water column variables (temperature and salinity) and sediment samples were taken in the same locations where faunistic sampling was carried out. A total of 101 species grouped in 55 families were recorded. Cephalopods were the most abundant group, with Abralia veranyi dominating in abundance, Octopus vulgaris in biomass and Illex coindetii and Todarodes sagittatus being the most frequently collected species. Multivariate analyses carried out separately with abundance data of demersal species, benthic species, bivalves, gastropods and cephalopods as well as of all molluscs, generally resulted in three main molluscan assemblages corresponding to a shelf assemblage (30-200 m depth), an upper slope assemblage (201-350 m depth), and a middle slope assemblage (351-800 m depth). PERMANOVA test revealed that significant differences of different groups of molluscs in relation to depth were more acute than to geographical sectors of the Alboran Sea (eastern, central, eastern and insular sectors). Abundance, biomass and species richness decreased with depth with a clear dominance of cephalopods in the slope. Significant geographical differences were mainly detected for demersal and benthic species as well as for gastropods and cephalopods between the insular sector (Alboran Island) and the western and eastern continental sectors. Both depth and temperature were the most influencing variables in the different CCA analyses using datasets of molluscs with different life styles and from different classes, but sedimentological variables displayed a more acute significant relationship with the benthic molluscs than with the demersal ones.
Spatial distribution of suspended solids during short-term high river discharge in the Bay of Koper, northern Adriatic Sea
Authors: SOCZKA MANDAC ROK , ŽAGAR DUŠAN
Published: June 2018

The Bay of Koper (BoK) located in the Gulf of Trieste (northern Adriatic Sea) is subject to a variety of anthropogenic influences; pollutants from inland are transported to the sea by the local rivers. The impact of high river discharge on suspended solids distribution was assessed by analysing results of an extensive measurement campaign conducted during two episodes of river flooding. The spatial analysis demonstrated the area influenced by fresh water and the distribution of inorganic suspended solids (ISS). The results were then used to calibrate the PCFLOW3D model and to simulate two episodes. A correlation was identified between the measurements and short-term simulations found in the central part of the bay. The results confirm the methods and the model used in this study to be appropriate for studying complex suspended solids processes in coastal areas.
HEMOTHORAX AS A LETHAL COMPLICATION OF THE SUBCLAVIAN VEIN PUNCTURE (CASE FROM PRACTICE)
Authors: Круглякова Людмила , Kruglyakova Lyudmila
Published: June 2018

Any professional medical activity carries the danger of complications. According to the ICD-10, any pathological process which resulted from a medical action is iatrogenesis. Now, when the aggression of therapy surpasses the severity of the disease, the problem of iatrogenesis is of particular importance. The complications caused by catheterization of a subclavian vein make 2.7-11.2% cases of iatrogenesis, serious complications – 1.2%. The hemothorax is an infrequent complication of this manipulation, its frequency doesn't exceed 0.4-0.6%. The hemothorax with a lethal outcome is a medical casuistry. This work is devoted to one case of traumatic iatrogenesis, i.e. to a complication of a puncture of a subclavian vein by hemothorax with the volume not less than 4.5 liters, with development of an acute respiratory failure and a lethal outcome.
ANALISANDO A CIDE-CONDECINE LICENÇA A PARTIR DAS CONSEQUÊNCIAS DA SUA INCIDÊNCIA NO SEGMENTO DE VIDEO POR DEMANDA PROGRAMADO (VOD – NETFLIX)
Authors: Martins Vinícius Alves Portela
Published: June 2018

Esse artigo tem por objetivo analisar a Condecine Licença (art. 32, I da MP 2.228-1/2001) incidente sobre os agentes que atuam no segmento de vídeo por demanda programado (vídeo on demand”-VOD), a partir da visão do pragmatismo jurídico e a luz do princípio da igualdade. Para isso, descreveremos basicamente noções básicas que fundam o pragmatismo jurídico e características do princípio da igualdade. Depois, analisaremos rapidamente o setor audiovisual, algumas de suas características, com foco nos segmentos de vídeo por demanda e de videodomestico. Após, analisaremos basicamente as características das contribuições interventivas e da Condecine Licença para que, por fim, discutamos as possibilidades da incidência da Condecine Licença sobre o segmento de vídeo on demand e suas implicações. Ao final, uma breve conclusão quanto as possibilidades futuras dessa exação incidente sobre o audiovisual e o referido segmento.
APONTAMENTOS ACERCA DA DESVINCULAÇÃO DE RECEITAS DA UNIÃO (DRU)
Authors: Jorge Alexandre Teixeira
Published: June 2018

O presente artigo tem como objetivo analisar a Desvinculação de Receitas da União (DRU) desde um breve histórico acerca dos fins almejados pela Constituição Federal de 1988 e os seus impactos nas finanças públicas, passando pelos fatores que ensejaram a criação de tal mecanismo, bem como pelas consequências por ele causadas em relação às contribuições sociais, contribuições de intervenção no domínio econômico e taxas. Por fim, abordamos a constitucionalidade da Desvinculação de Receitas da União.
Effects of amniotic membrane extract and deferoxamine on angiogenesis in wound healing: anin vivomodel
Authors: Farzan Ramyar , Moeinian Mahsa , Abdollahi Alireza , Jahangard-Rafsanjani Zahra , Alipour Abbas , Ebrahimi Marzieh , Khorasani Ghasemali
Published: June 2018

Objective:

Angiogenesis, formation of new vessels from pre-existing vessels, is an essential part of wound healing. We aimed to compare amniotic membrane extract with deferoxamine in angiogenesis and to assess any synergistic effect.

Method:

We examined four groups of rats (five per group): control, deferoxamine, amniotic membrane extract, and deferocxamine and amniotic membrane extract in combination. A distal-based skin flap was created. Deferoxamine (100mg/kg), amniotic membrane extract (0.1mg/ml), and the combination of both were injected subcutaneously every other day in 10 separate points (0.1 ml at each point) in the skin flap. On day 11, the animals were euthanised for histopathological evaluation.

Results:

Results indicated that the amniotic membrane extract raised the angiogenic markers, particularly new vessel numbers (p<0.008) and CD31+ compared with controls (p <0.003), and deferoxamine increased new vessel numbers and Von Willebrand factor (vWF) significantly compared with controls (p<0.008). There was an increase in angiogenic factors in the combined group, however, this was not statistically significant difference was observed. There was no difference between amniotic membrane extract and deferoxamine.

Conclusion:

Amniotic membrane extract or deferoxamine could be used interchangeably in angiogenesis within wound healing due to their high safety and availability.
Dust Image Fragments Ghosts
Authors: Dürig Regina
Published: June 2018

‘Dust Image Fragments Ghosts’ is an artistic exploration of my view of heterotopia from a writer’s perspective, the dimension of the fragmental, and the space in between the text and the reader. The starting point are 3D micrographs of dust samples from mobile and immobile cultural artefacts, which were part of a research project which investigated the aesthetic potential of dust and its information content from the perspective of the conservation and restoration. Dust has the power to make visible the absent, to show what must have been there. Fragments as a literary form show what might be there, in between or around. ‘Dust Image Fragments Ghosts’ follows the traces of seemingly empty space. It is a reflexive literary expedition into the landscapes of dust, a ghostly universe between micro and macro, reader and writer, image and imagination.
Finding prana: Sonic experiments in search of atemporal being
Authors: Collard Helen , Jackson Philippa
Published: June 2018

An entire life is encompassed between a first inhale and a final exhale: breath could be said to be our physical counter of time. In Yogic philosophy, prana is a concept meaning both breath and life and pranayama is the psycho-physical practice of regulating breath. It is here, in these liminal, atemporal moments of regulation that yogic practice considers key to controlling and mastering the mind. This article outlines an interdisciplinary research collaboration between an artist/pranayama practitioner and the Brain, Performance and Nutrition Research Center at Northumbria University. This bio-art project employs the use of functional Near Infrared Spectroscopy (fNIRS) to take real-time brain-state data during a live pranayama performance. fNIRS records the relative concentration change in oxygenated and deoxygenated haemoglobin levels in each hemisphere of the brain. This is sonified in real-time. fNIRS is now a re-appropriated control system for sound controlled by the artist’s moving breath (present and temporal) and the artist’s suspended breath (absent and atemporal). This correlative sonic biofeedback installation offers auditions that explore the possibility of perhaps another perceptual modality and another kind of being in the realm of the atemporal.
The work of art in the time of technogenesis
Authors: Titmarsh Mark
Published: June 2018

In our current environment the digital screen has become part of the daily rhythm of work and play. Yet as those digital screens become more refined and flatter they also approach the form and presence of a painted surface. A painting is also a screen, an image bounded by an edge, portable and primarily visual. Both kinds of screens have native temporal designs that are in productive tension with each other. By fracking into their differential relationship images are shown to metabolize time, arriving out of time for the sake of an unsustainable time, concealing an end of time, hidden beneath a fantastic time beyond time. This article will develop an alternative ontology of the image through interlocked notions of time, temporality, colour and presence based on contemporary painting, the plastic arts and an uncertain relation to the visual, brought on by information communication technologies. Using the ideas of Martin Heidegger, Richard Dienst and Bernard Stiegler it will be shown that by deconstructing everyday notions of time there is a fractal proliferation of temporal modes that releases an explosive plasticity of visual presence with a hue and density held somewhere between the agency of light and the plastic materiality of the screen.
Of hooded men and buildings without pants: Negotiating the images of universal desire
Authors: Quinteros Alejandro
Published: June 2018

This article explores images and their incipient conflicts in today’s global consumer monoculture. Fredric Jameson pointed out that today it would be easier to imagine the end of the world before an alternative to capitalism. As we have moved towards a globalized electronic capitalist economy, the hegemony of the image is concrete as signs and symbols appear to have become universal. Conflict follows in the representations of universality as definitions diverge between publicness, imageability, fear and desire. The global speed of universal representation of the signs and symbols of Euro-America-centric hegemony powers a binary phenomenon: the geographic dislocation of the consumers of our global consumer information society and the drive towards a global homogenized consumer monoculture.
The privileges of the quasi-photographic image
Authors: Toister Yanai
Published: June 2018

Numerical representation enables more than efficient processability and increased programmability. As it makes obsolete qualities that have previously been used to categorize individual media it also increasingly blurs the borders between them. Therefore it should be seen as no less than surprising that many contemporary systems still use images as their exclusive output channel. An associated conundrum is the fact that, of those many images, a baffling ratio appears in photographic form. Why this persistence on familiar pseudoverisimilitude? What are the privileges of the quasi-photographic aesthetic? Much wizardry is required to make data packages look recognizable. This decision, when taken by the creators of imaging algorithms, is of course ornamental but it is also much more. In acting as mere effect quasi-photographic images can function as sophisticated ‘go-betweens’ that weave together selected aspects of the physical world with the augmented world of data in ways that other media simply cannot. Thus, perhaps it is time to consider the possibility that the quasi-photographic need not be understood only as a form of interface but also as a concession required by and for our inferior human processing capabilities.
Atemporal photography: Image making out of time
Authors: lock Simon
Published: June 2018

This article introduces the concept of Anachronistic Intervention as a performative approach to public engagement experimentation at real-world events. The article presents an intervention involving formal portrait photography as a mechanism to explore the historic act of photography and shed light on the possible future evolution of digital image making.
Special effects and uncanny affect: CGI and the post-cinematic uncanny
Authors: Card William
Published: June 2018

This article introduces, presents and discusses the author’s practice-based artistic research. It situates the work, an investigation into the post-cinematic uncanny and the affective potential of visual effects technologies in art practice, within a theoretical context and moves towards the illumination of aspects of our relationship with certain types of digitally augmented moving imagery. The practice explores the post-cinematic uncanny as an intersection of visual arts, moving image, animation, cinema, television and visual effects linking it to theories of affect and post-cinema. It questions the nature and qualities of moving image in the twenty-first century, especially the pervasive and ubiquitous nature of computer-generated imagery (CGI) that supplements and augments digitally captured footage. In doing so it creates, explores and situates the post-cinematic uncanny within contemporary arts practice. The work employs technologies that were, until relatively recently, the preserve of high-end visual effects productions and aims to engender uncanny affect in its audience. It thus falls under the purview of Steven Shaviro’s speculations on post-cinematic affect. Shaviro’s ‘post-cinematic’ refers to the transformation of moving image practice and culture driven in part by the move to digital acquisition, manipulation, distribution, display and networked consumption. It provides a conceptual framework for this practice in relation to the wider context of cinema and moving image production. In the practice, visual effects technologies are employed site-specifically to create the impression of unknown yet familiar forms within the screen-space, creating new associations, fantastic implied narratives and extra-dimensional implications in otherwise mundane spaces. Still further removed from the profilmic event, these computer-generated images have no connection to the profilmic beyond an urge towards the ‘paradox of perceptual realism’. In this respect, CGI visual effects imagery may be analogous to Freud’s uncanny ‘double’.
Seleksi Bakteri Endofit Penghasil Senyawa Metabolit untuk Pengendalian Cendawan Patogen Terbawa Benih Jagung
Authors: Hanif Andini , Soekarno Bonny Poernomo Wahyu , Munif Abdul
Published: June 2018

Endophytic bacteria have been reported to produce metabolite as antifungal compound. This study was aimed to obtain endophytic bacteria which are able to produce metabolite to control Fusarium sp., a potential seedborne fungi on maize. Endophytic bacteria were screened by hypersensitive test on tobacco leaves and antagonistic test. Endophytic bacteria isolates with high growth inhibitor activity were selected and examined for their metabolite compound. Thre isolates, i.e. Lactobacillus sp. isolate EF14III, Pseudomonas sp. isolate ER1I, dan Aeromonas sp. isolate ER10I has the potential to inhibit Fusarium sp..  Metabolite compound of Pseudomonas sp. isolates ER1I was able to decrease the infection Fusarium sp. by 65.0% in blotter test and decreased infection of Fusarium sp. up to 59.5% and 60.5% in growing on test using water agar and sterile soil, respectively.  Cyclohexanone with concentration of 9.68% produced by Pseudomonas sp. isolat ERI1 may play a role as antifungal compound.
Penekanan Perkembangan Penyakit Bercak Ungu pada Bawang Merah oleh Cendawan Mikoriza Arbuskula
Authors: Sari Marlina Puspita , Hadisutrisno Bambang , Suryanti Suryanti
Published: June 2018

Arbuscular mycorrhizal fungi (AMF) is known to improve the growth of shallot (Allium cepa var. aggregatum) and strengthen the resistance of plants toward disease infection.  This research aimed to find out the roles of AMF in suppressing the development of purple blotch disease caused by  Alternaria sp. on shallot in Caturtunggal, Sleman, Yogyakarta.  Inoculation of AMF either on fertilization of N, P, K or without fertilization treatment resulted on higher plant height and number of leaves compared to those without AMF inoculation. The plant inoculated with AMF had lower purple blotch disease intensity and disease progression than control and fungicide treatment. The result showed that AMF, in addition to act as the bio-fertilizer, is a potential to be a biocontrol agent.
Peran Mikoriza Arbuskula pada Insidensi Penyakit Busuk Pangkal Batang Lada
Authors: Halim Halim , Mariadi Mariadi , Karimuna La , Hasid Rachmawati
Published: June 2018

Stem rot or foot rot disease caused by Phytophthora capsici is known as an important constraint on pepper cultivation. Research was conducted to determine the effect of arbuskula mycorhizal fungi (AMF) on incidence of foot rot disease of pepper seedlings.  The experiment was done in the net house and arranged using completed randomized design with 6 treatments, i.e. (1) soil infested by P. capsici (TPC) as negative control treatment, (2) sterilized soil (TS) as positive control treatment, (3) TPC with 5 g of AMF, (4) TPC with 10 g AMF, (5) TPC with 15 g AMF, and (6) TPC with 20 g AMF.   Observation involved plant height, number of shoots, disease incidence, the percentage of AMF infection on the roots of pepper plants, and pepper plants dependence on AMF. The results showed that the application of AMF at a dose of 20 g per 10 kg of soil effectively suppressed incidence of foot rot disease and improve plant growth
Deteksi Virus Terbawa Umbi Benih pada Bawang Merah Kultivar Biru Bantul
Authors: Nurviani Nurviani , Sulandari Sri , Somowiyarjo Susamto , Subandiyah Siti
Published: June 2018

Virus infection on shallots may cause mosaic of leaves and plant dwarf.  It is very important to know the identity of the virus as a requirement in determining viral disease management strategy.  The research is subjected to identify seed- transmitted viruses from shallot bulbs. Detection of virus from bulb was conducted by growing on test, followed by mechanical inoculation on shallot cultivar Biru Bantul, Chenopodium amaranticolor, and Nicotiana tabacum and morphological observation of virus particle by electron microscope. About 2 weeks after inoculation symptoms was observed, i.e. mosaic and dwarf on shallot cultivar Biru Bantul, local necrotic on C. amaranticolor, but symptomless on N. tabacum.  Filamentous particles of 650 nm and 800 nm in length was observed under electron microscope from plants with mosaic and dwarfing symptom, respectively.  This indicated the presence of 2 different seed-transmitted viruses on infected shallots.  Two species of shallot viruses, i.e. Shallot latent carlavirus (SLV) and Onion yellow dwarf potyvirus (OYDV) was most likely the main seedborne viruses on shallot bulb.  Identification based on nucleic acid and protein sequence analysis is necessary for further confirmation
PERAN PEMERINTAH DAERAH DI DALAM MELINDUNGI HAK ANAK DI INDONESIA
Authors: S Laurensiusarliman
Published: June 2018

Local government has a very vital role in the protection of children. This is stated in the articles of the Child Protection Act. In realizing the governance of the fulfillment of children's rights by the Regional Government must be fully realized and implemented properly. Decent City Children are the dream of every child, because the child will be raised properly and properly. Local Government as a government in direct contact with the life of children, should be more active and more critical, to voice the rights of children. Managing the fulfillment of children's rights by the Regional Government should be overseen by an institution that focuses on protecting, protecting, monitoring and monitoring the rights of children. Understanding of sustainable child protection needs to be taught from an early age to the community, because if people are taught early on about sustaining child protection, then child protection in Indonesia will not stop.
Peluang Penyelesaian Sengketa Perdata Tentang Tanah Melalui Alternative Dispute Resolution
Authors: Wiguna Made Oka Cahyadi
Published: June 2018

AbstractThe current developments, there are many land disputes that are vertical or horizontal. Issues concerning land affairs are often caused by salim claims over land rights. The intended land dispute is a civil dispute concerning the land. Achieving a win-win solution in the settlement of civil disputes over land is relatively difficult to materialize, if the settlement is resolved through a trial (litigation). The choice of law that can be chosen to obtain and realize a win-win solution in solving civil disputes over land is of course through alternative dispute resolution. By way of negotiation, mediation and conciliation. In the course of the settlement of civil disputes over land settled through alternative dispute resolution, the settlement can not ignore the applicable legal principles of the treaty.  Keywords: Land civil disputes, alternative dispute resolution and principles of contract.AbstrakPerkembangan yang terjadi saat ini, banyak terjadi sengketa pertanahan yang bersifat vertikal maupun horizontal. Permasalahan mengenai pertanahan yang terjadi sering disebabkan akibat salim klaim penguasaan hak atas tanah. Sengketa tanah yang dimaksudkan adalah sengketa perdata tentang tanah. Mewujudkan win-win solution dalam penyelesaian sengketa perdata tentang tanah relatif sulit dapat terwujud, apabila penyelesaiannya diselesaikan melalui sidang peradilan (litigation). Pilihan hukum (choice of law) yang dapat dipilih untuk memperoleh dan mewujudkan win-win solution dalam menyelesaikan sengketa perdata tentang tanah tentunya adalah melalui alternative dispute resolution. dengan cara negosiasi, mediasi dan konsiliasi. Dalam rangka penyelesaian sengketa perdata tentang tanah diselesaikan melalui alternative dispute resolution, maka penyelesaiannya tidak dapat mengabaikan asas-asas hukum yang berlaku mengenai perjanjian. Kata Kunci :   Sengketa perdata tanah, alternatif penyelesaian sengketa dan asas-asas    perjanjian.
Zur Edition historischer Tonaufnahmen – ein Praxisbericht
Authors: Liebl Christian
Published: June 2018

Auf Basis der Praxis des Phonogrammarchivs der Österreichischen Akademie der Wissenschaften präsentiert der Beitrag neben einigen generellen Überlegungen zwei Workflows zu inhaltlichen und technischen Aspekten einer kommentierten Edition historischer Tonaufnahmen. Thematisiert werden u. a. die quellenkritische Aufbereitung und Kontextualisierung sowie Re-recording, Digitalisierung und Signalverbesserung.
Langzeitverfügbarkeit von wissenschaftlicher Software im Bereich historisch-kritischer Musikedition
Authors: Röwenstrunk Daniel
Published: June 2018

Die Langzeitverfügbarkeit von Forschungsergebnissen und der dafür häufig notwendige langfristige Erhalt der Lauffähigkeit von Software ist eine gemeinschaftliche Herausforderung für Forschung, Softwareentwicklung und Gedächtnisinstitutionen. Es stehen verschiedene Maßnahmen wie Standardisierung, Emulation oder auch die Weiterentwicklung durch Open-Source-Communities zur Verfügung, die in unterschiedlichen Kontexten für unterschiedliche Arten von Software zum Einsatz kommen können.