bluuebunny/crossref_metadata_2025 huggingface dataset:
Rehabilitasi dan Renovasi Sarana Prasarana Sekolah Kabupaten Nunukan
Authors: Tahan Tahan
Published: August 2024

Membentuk dan mengembangkan sumberdaya manusia yang bermutu tinggi di daerah perbatasan, baik dari segi penguasaan dan kemampuan iptek, daya saing, dan pembentukan karakter, rasa dan sikap kebangsaan. Peningkatan Sarana prasarana Sekolah merupakan wujud perhatian Pemerintah dalam Peningkatan Sarana Prasarana Pendidikan di Daerah 3 T (Terdepan, Terluar, Tertingal). Manajemen pelaksanaan yang baik pada pekerjaan Rehabilitasi dan Renovasi Sarana Prasarana Sekolah Kabupaten Nunukan membawa dampak terhadap pelaksanaan konstruksi yang selesai dengan tepat waktu.tepat mutu. Maksud dan tujuan dilaksanakannya metode pekerjaan memberikan pengetahuan mengenai tahap – tahap dari proses pelelangan sampai dengan Serah Terima Pekerjaan. Proses pelaksanaan pekerjaan konstruksi Rehabilitasi dan Renovasi Sarana Prasarana Sekolah Kabupaten Nunukan memiliki tantangan mengatur mobilisasi pekerja, Mobilisasi material, Mobilisasi Tenaga Teknis, yang terbagi dalam 9 titik lokasi yang menyebar, serta letak geografis di 2 Pulau dan berbatasan langsung dengan Negara Malaysia. Serta keterbatasan Stock Material yang ada di lokasi pekerjaan.
ANALISA DAYA DUKUNG FONDASI TIANG TUNGGAL DENGAN DATA SPT
Authors: Lestari Asih Mitra Fenie
Published: August 2024

Analisa daya dukung fondasi memerlukan data penyelidikan tanah yang memadai dan pemilihan metode perhitungan daya dukung yang tepat untuk meminimalisir kesalahan dalam perencanaan. Penyelidikan tanah yang dilakukan pada karya tulis yaitu uji bor dalam dan SPT, serta uji laboratorium. Dalam menghitung daya dukung tiang digunakan nilai N-SPT yang telah dikoreksi terhadap energi hammer SPT, serta koreksi muka air tanah dan overburden pressure. Penyelidikan tanah dilakukan pada lokasi rencana Pabrik Kelapa Sawit di Desa Sungai Cabang, Kec. Kumai, Kab. Pangkalan Bun. Dari hasil uji menunjukkan bahwa terdapat lapisan tanah kohesif sangat lunak hingga lunak di sekitar kedalaman 8.00 – 18.00 m. Lapisan tanah keras mulai ditemukan di kedalaman 45.00 m hingga akhir kedalaman uji di 50.00 m. Fondasi tiang yang direncanakan yaitu spun pile diameter 500 m dengan panjang tiang tertanam 46.00 m. Metode perhitungan yang digunakan yaitu Meyerhoff (1956), Briaud et al. (1985), dan Decourt (1987). Dengan Safety Factor 3, daya dukung ijin rata-rata sebesar 183.90 ton (Metode Meyerhoff, 1956), 153.07 ton (Metode Briaud et al., 1985), dan 156.75 ton (Decourt, 1987). Kapasitas daya dukung ultimit dengan metode Meyerhoff (1956) lebih besar sekitar 15% dibandingkan dengan dua metode lainnya.
PERHITUNGAN SIMPANG TAK BERSINYAL PADA JALAN TRIKORA – JALAN A. YANI (LIANG ANGGANG) KILOMETER 19 BANJARBARU
Authors: Hawinuti Riska
Published: August 2024

Jalan Trikora dan Jalan A.Yani (Liang Anggang), Banjarbaru sebagai salah satu jalur alternatif penghubung antara Kota Banjarbaru, Banjarmasin dan Pelaihari memiliki peranan yang sangat penting untuk menunjang kelancaran transportasi dan roda perekonomian di daerah sekitarnya. Pemilihan lokasi ini untuk penelitian adalah karena secara visual, simpang tak bersinyal tersebut selalu mengalami kepadatan arus pada pagi, siang dan sore hari, walaupun disekitar simpang telah dilakukan pelebaran jalan di beberapa sisi dan perbaikan jembatan. Tujuan dari penulisan artikel ini adalah untuk menghitung volume lalu lintas dan kapasitas jalan puncak pada Simpang Tak Bersinyal pada Jalan Trikora – Jalan A. Yani (Liang Anggang) Kilometer 19, Banjarbaru. Metode penelitian ini menggunakan cara survei dan observasi langsung di lapangan untuk mendapatkan data masukan yang kemudian dihitung untuk mendapatkan hasil kinerja yang diinginkan. Perhitungan akan menggunakan pedoman PKJI 2014, BAB: Simpang. Berdasarkan hasil perhitungan volume lalu lintas yang paling besar terjadi pada hari Selasa, 06 Juni 2023 jam 11.00 - 12.00 WITA sebesar 2.228,00 skr/jam, kapasitas jalan sebesar 3.269,32 skr/jam, derajat kejenuhan sebesar 0,681, nilai tundaan sebesar 11,826 det/skr dengan kriteria tingkat pelayanan “B”.
Content Creator Strategies on Instagram Reels Account @Kumparancom to Boost Brand Engagement
Authors: Maharani Intan Ayu , Ardhanariswar Kartika Ayu
Published: August 2024

The aim of this study is to uncover the content creator strategies on the Instagram reels of the account @kumparancom in enhancing brand engagement within the #BerkahBersama campaign. This research employs the Goals-Plan-Action theory and the concept of The Circular Model of SOME by Regina Luttrell. This research uses case studies. Data collection involved observation, interviews, and documentation. The research findings indicate that Kumparan's content creators comprehensively follow the phases of the SOME model, namely share, optimize, manage, and engage. Each aspect is executed innovatively, incorporating the creators' creativity and considering the audience's needs. Leveraging the creators' presence, Kumparan is able to establish close interactions and connections with its audience. Not only has it succeeded in achieving engagement with measures like intention to recommend and loyalty, but the #BerkahBersama campaign has also evolved into an inspirational and meaningful social movement. Creators excel at presenting content through creative approaches, including humor, satire, and even sarcasm. Through these strategies, Kumparan successfully heightens brand engagement with its audience. Kumparan is seen as a competent, informative, current, unique, and audience-sensitive media portal.
Membangun Kepercayaan yang Berkelanjutan di Era Disruptif Komunikasi: Perspektif Media dan Komunikasi Digital
Authors: Dharmajaya Agung , Minangkabawi Harmonis
Published: August 2024

The purpose of this research is to find out the factors that can build sustainable trust in the field of disruptive communication from the perspective of digital media and communication. This research uses qualitative research methods. The data collection technique in this research is done by literature study by exploring journals, books and other information relevant to the research. The data that has been collected is then analyzed in three processes, namely data reduction, data presentation and conclusion drawing. The results showed that building sustainable trust in the disruptive communication field is an ongoing challenge. Transparency, accountability, education and collaboration are important strategies to maintain credibility and trust. The case of the presidential election illustrates the impact of media and digital communications on public perception, and emphasizes the need for responsible practices. As the media landscape continues to evolve, addressing potential issues such as algorithmic bias and privacy concerns is critical to ensure trust in digital communications remains intact.
KAJIAN SEMIOTIK JEAN BAUDRILLARD DALAM IKLAN TELEVISI NESTLE BEAR BRAND
Authors: Nararya Raden Roro Widya Dhana Kusuma , Laksana Rangga Cahyo Mukti
Published: August 2024

Iklan sebagaimana yang disampaikan oleh Kotler harus dapat memuat pesan yang menarik perhatian, mempertahankan ketertarikan, membangkitkan keinginan, serta menggerakkan tindakan. Dalam hal ini, iklan televisi Nestle Bear Brand berusaha menyajikan pesan melalui tanda-tanda visual berupa naga putih yang masuk ke dalam kaleng susu beruang.  Sebagai bagian dari masyarakat yang mengonsumsi tanda-tanda visual tersebut, penulis ingin mendapatkan kesimpulan akademis terkait absurditas kode dalam iklan televisi Nestle Bear Brand yang hingga kini masih menjadi perbincangan publik.  Dengan mengkaji fenomena tersebut dalam perspektif semiotika Jean Baudrillard, penulis mendapati kesimpulan bahwasanya tidak ada kebenaran absolut dalam sebuah iklan, yang ada hanya simulasi. Absurditas kode yang diciptakan oleh iklan televisi Nestle Bear Brand adalah sebuah media dalam menyampaikan pesan. Sebagai produsen makanan dan minuman terbesar di dunia, Nestle Bear Brand ingin menciptakan realitas untuk produknya guna lebih menanamkan citra di benak audiens. Adapun makna dari tanda visual yang diciptakan adalah bagaimana produsen susu steril ini selalu menjaga kualitas produknya hingga khasiatnya tidak perlu diragukan lagi, terdepan dalam hal menjaga keseimbangan tubuh dari berbagai ancaman penyakit.
Analisis Analisis Prioritas Pemilihan Supplier Pembelian Bahan Baku Menggunakan Metode TOPSIS Pada UD. XYZ
Authors: Yuneta Tia Octo , Aprian Fadli Nur , Sinaga Samuel
Published: August 2024

Abstrak
Pemilihan supplier dianggap sebagai suatu kegiatan strategis karena supplier memiliki peran krusial dalam menyediakan barang-barang vital atau kebutuhan jangka panjang. Keandalan supplier dapat tercermin melalui aspek-aspek seperti pengiriman yang efisien, kualitas produk, ketepatan waktu, dan kepuasan pelanggan. Penelitian ini dilakukan dengan tujuan untuk menetapkan prioritas supplier kayu glugu di UD. XYZ.Data dikumpulkan melalui studi literatur dan wawancara dengan pemilik UD. XYZ. Empat supplier dinilai berdasarkan kriteria kualitas kayu, harga, lama pengiriman, dan ketersediaan, yang ditentukan oleh pemilik. Metode Technique For Order Preference by Similarity to Ideal Solution (TOPSIS) dipakai untuk melakukan analisis data. Hasil penelitian menunjukkan bahwa supplier dengan indeks tertinggi di UD. XYZ adalah Supplier Bengkulu, dengan nilai indeks sebesar 0,898. Diikuti oleh Supplier Tasikmalaya dengan indeks 0,518, Supplier Tasikmalaya dengan indeks 0,497, dan Supplier Banjar dengan indeks 0,079. Hasil ini memberikan panduan dalam menentukan pilihan supplier yang optimal sesuai dengan kriteria yang diberikan.
 
Kata kunci: Kriteria, Pemilihan Supplier, Supplier kayu, Nilai Bobot, TOPSIS
VARS and HDMR Sensitivity Analysis of Groundwater Flow Modeling through an Alluvial Aquifer Subject to Tidal Effects
Authors: Samper Javier , Sobral Brais , Pisani Bruno , Mon Alba , López-Vázquez Carlos , Samper-Pilar F Javier
Published: August 2024

Groundwater flow and transport models are essential tools for assessing and quantifying the mi-gration of organic contaminants at polluted sites. Uncertainties in the hydrodynamic and transport parameters of the aquifer have a significant effect on model predictions. Uncertainties can be quantified with advanced sensitivity methods such as Sobol’s High Dimensional Model Reduction (HDMR) and Variogram Analysis of Response Surfaces (VARS). Here we present the application of VARS and HDMR to assess the global sensitivities of the outputs of a transient groundwater flow model of the Gállego alluvial aquifer which is located downstream the Sardas landfill in Huesca (Spain). The aquifer is subject to the tidal effects caused by the daily oscillations of the water level in the Sabiñánigo reservoir. Global sensitivities are analysed for hydraulic heads, aquifer/reservoir fluxes, groundwater Darcy velocity and hydraulic head calibration metrics. Input parameters in-clude aquifer hydraulic conductivities and specific storage, aquitard vertical hydraulic conductiv-ities, and boundary inflows and conductances. VARS, HDMR and graphical methods agree to identify the most influential parameters which for most of the outputs are the hydraulic conduc-tivities of the zones closest to the landfill, the vertical hydraulic conductivity of the most permeable zones of the aquitard, and the boundary inflow coming from the landfill. The sensitivity of heads and aquifer/reservoir fluxes with respect to specific storage change with time. The aquifer/reservoir flux when the reservoir level is high shows interactions between specific storage and aquitard conductivity. VARS and HDMR parameter rankings are similar for the most influential parameters. However, there are discrepancies for the less relevant parameters. The efficiency of VARS was demonstrated by achieving stable results with a relatively small number of simulations.
Six Dimension for Proof of Riemann Hypothesis
Authors: mousavi seyed kazem
Published: August 2024

In this paper, Riemann’s hypothesis is proved based on the gloden ratio and eccentricity of the ellipse in six dimensions. The proof of Riemann’s hypothesis affects all fields of science. In this article, logical and mathematical rules are proposed for the distribution, identification and classification of prime numbers. The prime numbers are the product of the complex conjugate of five prime numbers in dimensions. Also, even numbers and... are also classified based on prime numbers. Based on the findings of this research, identifying the properties and laws related to prime numbers establishes a deep connection between quantum mechanics and general relativity.
Green Alternatives for the Control of Fungal Diseases in Strawberry: In-Field Optimization of the Use of Elicitors, Botanical Extracts and Essential Oils
Authors: Soppelsa Sebastian , Cellini Antonio , Donati Irene , Buriani Giampaolo , Spinelli Francesco , Andreotti Carlo
Published: August 2024

Finding, safe and reliable alternatives to fungicides is one of the most actual challenges in agriculture. In this regard, our experiment investigated the effectiveness of different elicitors, botanical extracts and essential oils to control grey mould (Botrytis cinerea) and powdery mildew (Podosphaera aphanis) on strawberry plants. Furthermore, the defence mechanisms activated in plants after treatments were investigated. The trial was conducted in field conditions under plastic tunnel with strawberry plants ‘Elsanta’. In the first experiment, a group of strawberry plants was treated before flowering with elicitors [acibenzolar-S-Methyl – (BTH), chitosan], botanical extracts (seaweed extract, alfalfa hydrolysate) and essential oils (thyme and juniper) to evaluate their ability to reduce the incidence of grey mould infection on flowers. In the second experiment, another group of plants was treated before and after experimental inoculation with P. aphanis. Results indicated that the incidence of flower infected by B. cinerea was significantly reduced by thyme and juniper essential oils, showing values that were not significantly different from the commercial fungicide penconazole (positive control). As a consequence, final yield of essential oil-treated plants was +27% higher as compared to control. No significant differences emerged for other tested products against grey mould. However, gene expression analysis showed an up-regulation of FaEDS1, FaLOX and PR gene expression (FaPR1, FaPR5, FaPR10) in leaves treated with BTH. The other tested natural substances also elicited defence-related genes, however at a lower level than BTH. In the experiment, all treatments applied prior inoculation significantly reduced the incidence and severity of powdery mildew as compared to control. At 28 days after inoculation, chitosan and thyme essential oil applications performed similarly to their positive controls (BTH and penconazole, respectively), showing a significant reduction of disease incidence (by -84 and -92%) as compared to control. Post-inoculum application of essential oils showed similar effective action to fungicide (penconazole) in reducing incidence and severity of powdery mildew. These results indicate that the tested substances could be used as alternatives to fungicides for the control of grey mould and powdery mildew in strawberry, therefore representing a valuable tool for the control of these fungal diseases under the framework of the sustainable agriculture.
Satellite-Based Assessment of Particulate Organic Carbon (POC) concentrations in the Bay of Bengal: Spatial and Temporal Dynamics
Authors: Prodhan Md Abu Yousuf
Published: August 2024

Particulate Organic Carbon (POC) plays a crucial role in the marine carbon cycle, influencing carbon flux and many important ocean biogeochemical processes in the Bay of Bengal. The purpose of this study was to examine the seasonal and annual variability of POC in the Bay of Bengal (BoB) region and its correlation with Sea Surface Temperature (SST) and Chlorophyll-a (Chlor_a). This study uses level-3 POC, Chlor_a, and SST data from the Moderate Resolution Imaging Spectroradiometer (MODIS) Aqua satellite. The surface POC concentration in the Bay of Bengal declined at a rate of -1.30 mgm-3y-1 over a ten-year period (2003-12) and ranged from 86.48 mgm-3 to 110.93 mgm-3 with an average of (93.74±7.50 mgm-3). Seasonally, the mean POC was highest (97.40 mgm-3) during the post-monsoon (October-November) and lowest (79.36 mgm-3) in the pre-monsoon (March-May). Seasons were observed to have statistically significant differences in POC concentration in the study area (F(3,2155) = 6.298; p <0.05). A strong positive correlation between POC and Chlorophyll was observed whereas a week positive correlation between POC and SST was observed. POC was observed to be very prominent in post-monsoon (97.40 mgm-3) and in northeast-monsoon (97.14 mgm-3) and moderate to low in southwest (81.12 mgm-3) and pre-monsoon (79.36 mgm-3). The Bay of Bengal’s annual mean POC:Chlor_a ratio ranged from 97.56 mgm-3 to 332.89 mgm-3, indicating a significant impact of biological processes on POC composition. To see how POC fluctuation affects biogeochemical processes in the Bay of Bengal, deeper investigation is required.
Insight into Romanian Wild-Grown Heracleum sphondylium: Development of a New Phytocarrier Based on Silver Nanoparticles with Antioxidant, Antimicrobial and Cytotoxicity Potential
Authors: Segneanu Adina-Elena , Vlase Gabriela , Vlase Titus , Bejenaru Ludovic Everard , Mogoşanu George Dan , Buema Gabriela , Ciocîlteu Maria Viorica , Bejenaru Cornelia
Published: August 2024

Background: Heracleum sphondylium, a medicinal plant used in Romanian ethnopharmacology, proved to have a remarkable biological activity. The escalating concerns surrounding antimicrobial resistance led to a special attention to new efficient antimicrobial agents based on medicinal plants and nanotechnology. We report the preparation of a novel, simple phytocarrier that harnesses the bioactive properties of H. sphondylium and silver nanoparticles (HS-Ag system). Methods: The H. sphondylium low-metabolic profile was determined through gas chromatography–mass spectrometry and electrospray ionization–quadrupole time-of-flight–mass spectrometry. The morphostructural properties of the innovative phytocarrier were analyzed by X-ray diffraction, Fourier-transform infrared spectroscopy, Raman spectroscopy, dynamic light scattering, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The antioxidant activity was evaluated using total phenolic content, ferric reducing antioxidant power, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro assays. The antimicrobial activity screening against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli was conducted using the agar well diffusion method. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay estimated the in vitro potential cytotoxicity on normal human dermal fibroblasts (NHDF) and cervical cancer (HeLa) cells. Results: A total of 88 biomolecules were detected, such as terpenoids, flavonoids, phenolic acids, coumarins, phenylpropanoids, iridoids, amino acids, phytosterols, fatty acids. HS-Ag phytocarrier heightened efficacy in suppressing the growth of all tested bacterial strains compared to H. sphondylium and exhibited a significant inhibition of HeLa cell viability. Conclusions: The new HS-Ag phytocarrier system holds promise for a wide range of medical applications. The data confirms the capacity to augment pertinent theoretical understanding in the innovative field of antimicrobial agents.
Cellular Self-Maintenance Drives the Evolution of Tissues and Organs: Supra-Functionalization and the Origin of Levels of Organization
Authors: Pavlicev Mihaela , DiFrisco James , Love Alan C. , Wagner Gunter P.
Published: August 2024

Although evolutionary transitions of individuality have been extensively theorized, little attention has been paid to the origin of levels of organization within organisms. How and why do specialized cells become organized into specialized tissues or organs? What spurs a transition in organizational level in cases where the function is already present in constituent cell types? We propose a model for this kind of evolutionary transition in terms of two key features of cellular self-maintenance: metabolic constraints on functional performance and the capacity for metabolic complementation between parenchymal and supporting cells. These features suggest a scenario whereby pre-existing specialized cell types are integrated into tissues when changes to the internal or external environment favor offloading metabolic burdens from a primary specialized cell type onto supporting cells. We illustrate this process of “supra-functionalization” using the nervous system and the pancreas as examples. The model reveals distinctive concerns for explaining this kind of evolutionary transition—instead of the suppression of “cheating” by components, the issue is how a tissue comes under modular genetic control as a distinct body part—and also points to a novel form of evolutionary complexity-increasing ratchet.
Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice with Mitochondrial Dysfunction
Authors: Cossu Davide , Tomizawa Yuji , Noda Sachiko , Momotani Eiichi , Sakanishi Tamami , Okada Hanna , Yokoyama Kazumasa , Sechi Leonardo A. , Hattori Nobutaka
Published: August 2024

This study aimed to explore the intricate relationship between mitochondrial dysfunction, infections, and neuroinflammation, focusing specifically on the impact of pathogenic epitopes of Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA1) in a mouse model of mitochondrial dysfunctions. The investigation included female middle-aged PARK2-/- and C57BL/6J wild-type mice immunized with EBNA1386-405 or with active experimental autoimmune encephalomyelitis (EAE) induction by myelin oligodendrocyte glycoprotein (MOG)35-55 peptide. PARK2-/- mice developed more severe EAE than wild-type mice. Following immunization with EBNA1386-405, only PARK2-/- exhibited symptoms resembling EAE. During the acute phase, PARK2-/- mice immunized with either MOG35-55 or EBNA1386-405 exhibited similar infiltration of T cells and macrophages in the spinal cord and decreased GFAP expression in the brain. However, EBNA1386-405 -immunized PARK2-/- mice showed significantly increased frequencies of CD8a+ T cells and CD11c+ B cells, and distinct cytokine profiles in the periphery compared to wild-type controls. These findings highlight the role of EBV in exacerbating inflammation, particularly in the context of mitochondrial deficiencies.
Sucrose and Moringa (Moringa oleifera Lam.) Leaf Extracts as Natural Additives to Prolong the Vase Life of Rose (Rosa × hybrida) Cut Flowers
Authors: Telebrico Marjune T. , Bendanillo Alan A.
Published: August 2024

This study explored the effectiveness of natural additives in prolonging the life of cut roses. A Completely Randomized Design (CRD) was used, with four different treatments: distilled water (control), a sucrose solution, moringa leaf extracts, and a combination of sucrose and moringa. The roses were observed over eight days to assess various factors such as leaf drop, stem rotting, bent necks, petal drop, flower condition, and petal color. The results showed that the combined treatment of sucrose and moringa led to the highest number of leaf drops, with 15 leaves dropping by day five. Distilled water resulted in 12 dropped leaves, moringa extract caused four leaves to drop, and sucrose had the least impact with only two leaves dropping. The combination treatment also caused the most significant stem rotting (32.75 mm) and the most bent necks (14 roses). In contrast, roses treated with sucrose or moringa separately had better outcomes, with the least bent necks and minimal leaf drops. For petal drop, the combined treatment again had the worst results, with eight petals dropping, followed by distilled water with six petals. The overall flower condition was poorest with the combined treatment, scoring 1 (completely open/damaged), while roses treated with sucrose or moringa separately had better scores, indicating they remained fresher. Petal color was also most affected by the combined treatment, which resulted in a light brown color, whereas the separate treatments maintained a darker red hue. Hence, while sucrose and moringa are beneficial when used individually, their combination negatively impacts the longevity and appearance of cut roses.
Comparison of Leadership Priorities Among Undergraduate and Graduate Nursing Students
Authors: D’Anna Barbara Ann , Boyd Beth , Levitt Cheryle
Published: August 2024

Effective leadership is reflected by evidence-based attributes, competencies, and behaviors. The Future of Nursing Report (2011) identified a gap in leadership knowledge, recommending development of creative and innovative strategies to strengthen nursing leadership curricula. These results provided an impetus and charge for nursing education to reexamine and revise leadership content. This mixed methods study analyzed baccalaureate and masters nursing students’ development of their leadership knowledge and skills. Through reflections, undergraduate (n=60) and master’s (n=52) students identified their perceived priorities and tips for success for nursing leaders across the healthcare continuum. Qualitative content analysis aligned students’ comments with the American Organization for Nursing Leadership (AONL) Nurse Executive Competencies (2015). Descriptive data provided the summaries of which leadership competencies were represented. Alignment to the competencies varied, commensurate with the level of educational program: BSN-level management skills vs. MS-level executive skills. Common responses across both programs prioritized communication, professionalism, and leadership behaviors. The results provide an opportunity for students’ synthesis of leadership skills and practices, may guide educators in the design of multi-level leadership curricula, and support development of clinical leaders in practice. This study was prospectively registered with the Campus Institutional Review Board on January 23, 2023, protocol code: 0086-001.
Learning Beyond Boundaries: Addressing the Transformative and Challenging Impacts of Artificial Intelligence on Education
Authors: Jho Hunkoog
Published: August 2024

The rapid advancement of artificial intelligence (AI) brought about significant opportunities and challenges in educational environment. It is disputable whether the application of AI to education is beneficial or not regarding human learning and teaching. This study aims at exploring the implications of the evolving educational landscape by comparing and discussing human and AI learning processes. Even though AI is not a conscient agent, it does not spell out any words randomly but provide meaningful texts with any reasoning. It helps us to understand human learning better by comparing learning in biological and artificial intelligences. Moreover, the new concepts in learning in AI come about the change of learning paradigm such as connectionism/connectivism. After all, AI will empower the abilities of learning and teaching for students as well as teachers. This study will give some implications for the future education with AI.
Segment Anything Model (SAM 2) Unveiled: Functionality, Applications, and Practical Implementation Across Multiple Domains
Authors: Setu Jahanggir Hossain , Islam Mahmudul , Pasha Syed Tangim , Halder Nabarun , Hossain Ekram , Mahmud Asif , Islam Ashraful , Alam Md. Zahangir , Amin M. Ashraful
Published: August 2024

Segment Anything Model 2 (SAM 2) is a state-of-the-art development by Meta AI Research, designed to address the limitations of its predecessor, SAM, particularly in the realm of video segmentation. SAM 2 employs a transformer-based architecture enhanced with streaming memory, enabling real-time processing for both images and videos. This advancement is important given the exponential growth of multimedia content and the subsequent demand for efficient video analysis. Utilizing the SA-V dataset, SAM 2 excels in handling the intricate spatio-temporal dynamics inherent in video data, ensuring accurate and efficient segmentation. Key features of SAM 2 include its ability to provide real-time segmentation with minimal user interaction, maintaining robust performance even in dynamic and cluttered visual environments. This study provides a comprehensive overview of SAM 2, detailing its architecture, functionality, and diverse applications. It further explores the model's potential in improving practical implementations across various domains, emphasizing its significance in advancing real-time video analysis.
New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-inflammatory, DNA Gyrase B Inhibition and In Silico Studies
Authors: Abd El-Karima Somaia S. , Anwara Manal M. , Syama Yasmin M. , Awad Hassan M. , El-Dein Asmaa Negm , El-Ashrey Mohamed K. , Abdelwahed Sameh
Published: August 2024

The alarming rise of antibiotic resistance has made it imperative to find novel antimicrobial medications. This study reports the design and synthesis of new molecules based on benzofuran-pyrazole scaffolds hybridized with various N/O heterocycles using the molecular hybridization process. The newly synthesized candidates were confirmed using micro-analytical and spectral analyses, and their antimicrobial characteristics were assessed against different bacterial and fungal isolates in comparison with novobiocin and clotrimazole as antibacterial and antifungal standards, respectively. In addition, the new compounds were further evaluated as in vitro antioxidants and anti-inflammatory congeners. The most promising broad spectrum antimicrobial compounds 9, 10 with values ranging from 2.50-20.60 μg/mL were further examined as E. coli DNA gyrase B enzyme suppressors using novobiocin as a reference drug.
In silico computational studies revealed that compound 9 produced a good fit in the active site of E. coli DNA gyrase B in comparison to novobiocin. Additionally, the drug similarity and ADMET parameters of compound 9 were examined in conjunction with the antibiotic ciprofloxacin, making it a potential candidate for further development as a promising antimicrobial agent.
Unified Model for Predicting the Size and Shape Dependent Cohesive Energy and Melting Temperature of Semiconducting Nanomaterials
Authors: Sherka Gebru , Berry Habte , Zhang Qinfang
Published: August 2024

Predicting the thermophysical properties of designed materials at the nanoscale is crucial. However, this remains a significant challenge despite numerous efforts by researchers and scientists. This paper presents a unified thermodynamic model to study the size and shape-dependent cohesive energy and the melting temperature of semiconductor nanosolids, including InSb, ZnSe, CdS, and CdSe. The model provides insight into the thermal stability of nanosolid materials by considering the combined impact of size, shape, and packing density. The finding indicates that smaller nanoparticles exhibit a lower cohesive energy than larger ones. Our unified thermodynamic model yields results consistent with experimental values and demonstrates a closer agreement than those from the universal liquid drop model of size-dependent cohesive energy, which includes a shape factor of α = 2/3 for nanowires. According to the results, the melting temperature of nanoparticles drops as their size decreases. Below a diameter of 5 nm, this trend becomes more noticeable. In the nano-scale domain, the nanoparticle's shape also matters greatly. In particular, compared to tetrahedral nanoparticles, nanowires show a lesser reduction in melting temperature. Also, up to a diameter of roughly 10 nm, the melting temperatures of these nanoparticles rise with particle size. The search results show that, especially in the < 5 nm size range, the size and shape of nanoparticles significantly affect their melting point. The models accurately predict the relationship between particle size and melting point for various semiconductor nanomaterials, aligning with experimental findings. Interestingly, the information indicates a potential preference for these nanomaterials to form nanowire structures in the < 5 nm size range. Our research offers helpful insights into the thermophysical properties of these semiconducting materials, which may have significant implications for their use in a diversity of technological applications.
The Social Robotics Gamble
Authors: Sequeira Joao Silva , González Álvaro Castro , Castillo José Carlos , Martin Fernando Alonso , Salichs Miguel Angel
Published: August 2024

Will human societies accommodate social robots, given the current development rate? Are we under a novelty effect? Can (and should) social robots compete with intelligent agents (e.g., software robots) for the attention of humans? Will the current development of machine learning be the motor of social robotics? What kind of robotics products and culture can we expect that will emerge? These are relevant questions to assess the sustainability of social robots and how they will change business practices and lifestyle. Speculative/exploratory arguments on these topics are possible and have been mostly left out of research papers. This, however, results in an unconventional structure where the novelty comes from the questioning of the role of Social Robotics that has not been duly addressed in the literature. The paper raises questions and (i) presents arguments supporting sustainability grounded on experiments in real-world scenarios, and (ii) identifies challenges according to multiple viewpoints. These are questions for which assertive answers are not found in the literature. Besides the answers to the above questions, the conclusions point to pathways we believe social robotics can evolve, e.g., incorporating maximal knowledge on how humans work.
Environmental Damage Costs of Insurance Companies
Authors: Bressan Silvia
Published: August 2024

We examine worldwide Property and Casualty and Life and Health insurance companies from 2004 until 2023, implementing panel regression models and mediation analysis to show that insurers raise their reserves when they face increasing costs for their potential environmental damages, ultimately reducing their profitability and underwriting capacity.
Our findings extend to the insurance sector the previous evidence on banks, demonstrating that environmental damages could affect profits and solvency of financial intermediaries.
These insights are important especially for insurance managers and regulators.
Women Utilization of Urban Green Spaces in Jordan
Authors: Zeadat Zayed
Published: August 2024

This study seeks to comprehend the complex and diverse dynamics of women's encounters with urban green areas in the specific setting of Jordan. The utilization of the focus group methodology facilitated the organization of unstructured talks involving a cohort of twenty-seven female participants, which yielded intricate and perceptive perspectives on their opinions. This study revealed a widespread pattern of stigmatization and unfavorable assessment of women who utilize public areas, which is strongly ingrained in cultural norms and gender expectations. Women were also concerned about the potential harm to their reputation and the censure of society, which ultimately deterred women from participating in public spheres. The research thus centers on the close proximity and insufficiency of urban green areas in Jordan, which is worsened by high urban density. Insufficient lighting and security measures are responsible for further limiting women's access to areas like these, which also raises concerns about safety. Recent evidence has revealed deficiencies in infrastructure designed to accommodate the needs of women, particularly in public restroom facilities. This study emphasizes the immediate necessity for a fundamental change in urban policy and planning, towards more inclusive approaches. Within this strategic framework for urban policy, there is a strong emphasis on incorporating aesthetics, comfort, and safety elements to enhance the whole urban experience for women. Consequently, addressing this issue necessitates using gender-responsive strategies in urban design and planning. This includes enhancing the quality, cleanliness, and privacy aspects of facilities to cater to the specific needs of women and improve their overall well-being. This study contends that any ongoing discussion on sustainable urban development in Jordan must take into account the interaction between urbanization, accessibility to public spaces, and the well-being of women. Therefore, it is necessary to implement a worldwide effort to advocate for urban policies that include both genders. This program aims to propose innovative approaches to governance, security measures, and municipal infrastructures that are sensitive to gender-related issues.
A Comprehensive Transcriptomic and Proteomics Analysis of Candidate Secretory Proteins in Rose Grain Aphid, Metopolophium dirhodum (Walker)
Authors: Gebrekidan Atsbha Gebreslasie , Zhang Yong , Chen Julian
Published: August 2024

The Rose grain aphid, a notable agricultural pest, releases saliva while feeding. Yet, there is a need for a comprehensive understanding of the specific identity and role of secretory proteins released during probing and feeding. Therefore, a combined transcriptomic and proteomic approach was employed to identify putative secretory proteins. The transcriptomic sequencing result led to the assembly of 18030 unigenes out of 31344 transcripts. Among these, 705 potential secretory proteins were predicted and functionally annotated against publicly accessible protein databases. Notably, a substantial proportion of secretory genes (71.5%, 69.08%, and 60.85%) were predicted to encode known proteins in Nr, Pfam, and Swiss-Prot databases, respectively. Conversely, 27.37% and 0.99% of gene transcripts were predicted to encode known proteins with unspecified functions in the Nr and Swiss-Prot databases, respectively. Meanwhile, the proteomic analysis result discovered, 30 salivary proteins. Interestingly, most salivary proteins (53.3% proteins) showed close similarity to A. craccivora, while 36.67% to A. pisum and A. glycines. However, to verify the expression of these secretory genes and characterize the biological function of salivary proteins further intervention should be geared towards gene expression and functional analysis.
Harnessing the Therapeutic Potential of Salvia spp. in Ameliorating Obesity: A Special Focus on Mechanistic Insights through Gut Microbiota Dynamics
Authors: SHARMA DIVYANI , MADAAN KASHISH , JAWANDA ISHWERPREET KAUR , SONI THOMSON , KOUL KHYATI , SINGH PRANJALI , KUMARI SEEMA
Published: August 2024

Obesity looms large in the contemporary health landscape, extending its impact beyond physical appearance to influencing overall well-being. This slow intruder subtly weaves its influence through society, affecting individual health and presenting a significant public health dilemma. Beyond the visible weight gain, a web of interconnected health issues emerges, from cardiovascular complications to metabolic disorders, casting a pervasive shadow over the pursuit of a healthy, fulfilling life. In response to the escalating prevalence of obesity and its associated health complexities, there is a growing interest in swift weight management medications. However, current pharmacotherapies targeting crucial weight management pathways often fall short due to substantial side effects outweighing their benefits. Recently, plant extracts have emerged as potential regulators of lipid metabolism and obesity by influencing gut microbiota composition and abundance. This comprehensive review takes deep dive into the potential roles of Salvia spp. phytochemicals as health-promoting agents, with a specific focus on the anti-obesity properties of Salvia spp. by compiling a wealth of in-vitro, in-vivo and clinical studies. Drawing from the latest research, we unravel the potential of Salvia spp. by shedding light on their underlying mechanisms intertwined with gut microbiota dynamics. As scientific inquiry progresses, unraveling the intricate interplay between plant extracts, gut microbiota, and metabolic health holds tremendous promise for addressing the escalating global burden of obesity. This review is a humble attempt to provide a valuable synthesis of current knowledge, so as to pave the way for future advancements in pursuit of effective anti-obesity strategies for clinical interventions.
miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma
Authors: Escobar Moreno Jose Daniel , Fajardo Castiblanco Jose Luis , Riaño Rodriguez Laura Camila , Barrios Ospina Paula Marcela , Zabala Bello Carlos Andres , Muñoz Roa Esther Natalia , Rivera Escobar Hernan Mauricio
Published: August 2024

Reactive oxygen species (ROS) are intermediates in oxidation-reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment and microRNAs expression in melanoma is not fully understood. The aim of this review is to analyze the involvement of miRNAs in the modulation of signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma and therefore a potential footprint poorly documented.
A New NDSA (Normalized Differential Spectral Attenuation) Measurement Campaign for Estimating Water Vapor along a Radio Link
Authors: Facheris Luca , Cuccoli Fabrizio , Cortesi Ugo , del Bianco Samuele , Gai Marco , Macelloni Giovanni , Montomoli Francesco
Published: August 2024

The Normalized Differential Spectral Attenuation (NDSA) technique was proposed years ago as an active method for measuring Integrated Water Vapor (IWV) along a Ku/K-band radio link immersed (totally or partially) in the troposphere. The approach is of the active kind, as it relies on the transmission of a couple of sinusoidal signals, whose power is measured at the receiver, thus providing the differential attenuation measurements from which IWV estimates can be in turn derived. In 2018, a prototype instrument providing such differential attenuation measurements was completed and set up for a first measurement campaign aimed at demonstrating the NDSA method. By the end of June 2022, the instrument was profoundly modified and upgraded so that a second measurement campaign could be carried out from August 1 to November 30, 2022. The transmitter was placed on the top of Monte Gomito (44.1277°lat, 10.6434°lon, 1892 m a.s.l.) and the receiver on the roof of the Department of Information Engineering of the University of Florence (43.7985°lat, 11.2528°lon, 50 m a.s.l.). The resulting radio link length was 61.15 km. Four ground weather stations of the regional weather service were selected among those available. In this paper, we describe the upgraded instrument and present the outcomes of the new measurement campaign, whose purpose was mainly to compare the IWV estimates provided by the instrument with the ground sensors measurements of air temperature, air humidity, barometric pressure, and rainfall.
Study on Safety Tunneling Technology of Secondary Outburst Elimination by CO2 Gas Fracturing in High Outburst Coal Seam
Authors: Zongwei Xu , Junsheng Zhang , Yunxing Cao , Zhenzhi Wang , Xinsheng Zhang
Published: August 2024

The No. 3 coal seam in the Yuxi Coal Mine has a measured maximum gas content of 25.59 m3/t, along with a maximum gas pressure of 2.9 MPa, indicating its high risk to gas and outbursts. To mitigate outburst risks of the coal seam, the 1301 working face has been implemented gas pre-drainage measures by grid boreholes from underlying roadways. After one year of extraction, it was confirmed that the gas content at all 33 test sites was below 8 m3/t, meeting the outburst prevention standards. However, during subsequent coal tunnel excavation, the gas desorption index K1 value frequently exceeded the standard, resulting in numerous occurrences of abnormal gas emission or small-scale outbursts. To tackle the challenges associated with safe excavation following the first round regional outburst prevention measures, a research and industrial trial of CO2 gas fracturing(CO2-Frac) technology for secondary outburst prevention and rapid excavation was completed. Results show that the dual-hole and high-pressure (185MPa) CO2-Frac considerably contribute to outburst prevention. K1 exceedances per hundred meters of tunnel excavations were from average 2.54 without CO2-Frac to average 0.28 after the new technology being implemented, leading to a eight fold reduction. Additionally, the monthly excavation footage increased from average 81.64 m without CO2-Frac to average 162.42 m with CO2-Frac, resulting in a 2-fold improvement. The dual-hole and high-pressure CO2-Frac is an advanced technology for safe and efficient excavation for secondary outburst elimination in highly outburst-prone coal seams in the Yuxi Coal Mine, with potential for widespread application in similar coal seam conditions.
Retrospective Radiographic Analysis of Peri-Implant Bone Loss in Mandibular Full-Arch Implant Rehabilitations
Authors: Giordano Francesco , Acerra Alfonso , Gasparro Roberta , Galdi Marzio , D’Ambrosio Francesco , Caggiano Mario
Published: August 2024

Can the type of implant rehabilitation influence peri-implant bone loss in case of full-arch mandibular prosthesis? The purpose of the study was to assess, by orthopantomograms (OPG), bone loss around implants in different types of implant-supported prosthetic rehabilitations and evaluate potential risk factors associated with the number and location of implants that may have an association with bone defect. A radiographic study was conducted on 22317 OPGs in the time range from 2010 to 2024. All OPGs with implant-supported prosthetic mandibular rehabilitations were included in the study. A total of 155 OPGs were evaluated, with peri-implant bone loss identified in 64 (41.3%). Distal implants (furthest from the center) across various positioning patterns were most susceptible to bone loss, with positions 3.6 and 4.6 demonstrating the most frequent occurrences (25 and 26 cases, respectively). χ² test revealed significant associations between both implant positioning pattern (p < 0.001) and number of implants (p < 0.001) with peri-implant bone loss. Also by updating the sample of OPGs, increased susceptibility to bone resorption was found for implants placed distal to the mental foramen compared to mesial ones in full-arch implant-supported fixed prostheses. Prospective clinical studies will then be useful to investigate this finding further.