bluuebunny/crossref_metadata_2025 huggingface dataset:
Eine erste Abschätzung des globalen Energieverbrauchs von Kugellagern
Authors: Bakolas Vasilios , Roedel Philipp , Koch Oliver , Pausch Michael
Published: September 2021

Rolling element bearings are found in every piece of machinery and are, therefore, a source of energy losses that can’t be ignored. During the last years a series of energy efficient bearings have been developed using specific designs or new materials aiming to reduce the losses of a bearing without sacrificing its load carrying capacity. The effect that these designs have on the global energy consumption hasn’t been quantified until now. A methodology to estimate the energy losses of the usage of a specific bearing type on a global scale is presented in this paper. The method, that is based on current standards, provides a first approximation for the determination of the energy losses of bearings and it is tested for its plausibility. The pros and cons of the proposed method are discussed, and a proposal is made on how to calculate the potential energy efficiency of newer designs.
Ensuring quality control of educational activities of higher educational institutions
Authors: Kolodii Ihor , Kostolovych Tetiana , Kolomiiets Tetiana , Muratova Iryna , Tsoi Mykola
Published: September 2021

The study aims to establish a general concept and stages of modeling the implementation of quality control of the educational process; to determine the assessment of employees of the institution of higher education presented an innovative model of quality control using automated learning and control systems (ALCS). The main method was the experiment, the study also used questionnaire and observation methods. The data was analyzed through content and thematic analysis. The main hypothesis is that the implementation models of quality control of education should be comprehensive, meet the mission and strategy of the educational institution and require continuous improvement. The result is the establishment of the main conceptual framework for the formation of an innovative model of quality control, should focus on quality education, use a wide range of advanced technologies, effective communication, improve learning strategies. A further perspective is to investigate the effectiveness of models of quality control of the educational process.
Evolution of customs logistics technologies in Eurasian economic space
Authors: Shapovalova Irina Mikhailovna
Published: September 2021

A retrospective study of the evolution of customs logistics technologies in the Eurasian economic space is carried out, taking into account the stages of development of integration processes. The specific composition and features of the application of special simplifications and logistics technologies for customs declaration of goods in the single customs territory of the Eurasian Economic Union are determined. The innovations of the institute of authorized economic operators in the Eurasian Economic Union are studied, their subject composition is characterized and the peculiarities of performing logistics operations in international supply chains are considered. Promising directions for the development of customs logistics technologies are being established, taking into account the digitalization of customs operations, the organization of customs control, and the transformation of the institute of authorized economic operators. The logistics technologies of customs declaration are identified (preliminary informing, preliminary customs declaration of goods, submission of an incomplete customs declaration, periodic customs declaration, release of goods before filing a customs declaration, temporary periodic customs declaration of goods, declaration of goods in unassembled or disassembled form, “remote release”, “dry port”, “remote payment of customs payments”). The technologies of customs logistics are highlighted, which can be used only by authorized economic operators-participants in foreign economic activity and / or logistics operators that meet the requirements for inclusion in the Register of Authorized Economic Operators. It is concluded that in the process of the evolutionary development of customs logistics in the Eurasian economic space, a new institute of logistics intermediaries is being formed.
Role of entrepreneurial activities for Nigeria’s economic recovery and growth (a case of studying Nigerian enterprises)
Authors: Obi Chinazor Franca
Published: September 2021

The paper presents the empirical analysis of the effect of entrepreneurship activity on the economic recovery and growth using SMEs in Nigeria. Two cities from each of the six geopolitical zones and four sectors of the economy were selected for the study. The total number of the selected four sectors form the population of the study while the sample size is seven hundred and twenty. The analysis employs the Ordinary Least Square techniques and time-series data for the economic recovery. The study adopts the Phillips-Perron test procedure to examine the stationarity of the study variables. The Johansen Cointegration test was employed to establish the cointegration of the variables and the unrestricted Error Correction Model was used to examine the speed of the alteration to the equilibrium. It has been inferred that the entrepreneurship activity and ERG are integrated of order (1(0)). This is established by the explanatory power of the models result of R value of 0.274 and R2 approximated to 0.075. The result shows a low positive impact of entrepreneurial activities on ERG. The study proves that, despite the crash in oil industry, the entrepreneurship has contributed positively to the Nigerian economy although at a low level. The study suggests that the government should support the development of entrepreneurship
Understanding Responsibility in Stem Cell Research
Authors:   PhD-student, University Medical Center Utrecht, The Netherlands, Assen Lars ,   E-mail: l.s.assen@umcutrecht.nl, Jongsma Karin ,   Assistant Professor, University Medical Center Utrecht, The Netherlands, Bredenoord Annelien ,   Professor, University Medical Center Utrecht, The Netherlands
Published: September 2021

"Over the years, numerous ethical implications in stem cell research have been identified. Consequentially, there is a need to anticipate, prevent and/or mitigate these implications. In literature and in the guidelines of the International Society for Stem Cell Research some of these implications have been reframed into (moral) responsibilities. What exactly is meant by responsibility and which notions of responsibility are important often remains unclear. As a consequence, this encumbers the possibility to deal with these responsibilities in a systematic way. Therefore, the goal of this paper is to discuss how the concept of responsibility in stem cell research could best be understood. This paper addresses which notions of responsibility are relevant for the field of stem cell research. This will be done by first distinguishing between backward-looking and forward-looking notions of responsibilities, where backward-looking responsibilities are about reactive attitudes and forward-looking responsibilities are about what could be expected from someone to prevent ethical implications. Subsequently, ethical implications of and wrongdoings in stem cell research will be categorized in these notions of responsibility. Taking one step back and looking at the different notions of responsibility could help to identify gaps in responsibilities as well as to distinguish obligatory and supererogatory responsibilities. Consequentially, this informs how to prioritize, distribute and delegate responsibilities over the different stakeholders in stem cell research. This paper concludes by discussing the distribution of responsibilities and different strategies to promote responsibility in stem cell research. "
The Comparative Effectiveness of Synchronous and Asynchronous Online Bioethics Lecture Delivery on Student Learning in Discussion Board Posts
Authors:   Ph.D. Student in Philosophy, Schiff Jenny Clark ,   Ethics Fellow, The Graduate Center, CUNY,   Icahn School of Medicine, New York City, USA,   E-mail: jschiff@gradcenter.cuny.edu, Greer Michael L. J. ,   Ph.D. Student in Philosophy; Ethics Fellow,The Graduate Center, CUNY; Icahn School of Medicine, New York City, USA; E-mail: mgreer@gradcenter.cuny.edu, Felder Ryan ,   The Graduate Center, CUNY; Icahn School of Medicine, New York City, USA, Kolak Julia ,   The Graduate Center, CUNY; Icahn School of Medicine, New York City, USA, Smolenski Joanna ,   The Graduate Center, CUNY; Icahn School of Medicine, New York City, USA, Ferguson Kyle ,   Ph.D., NYU Grossman School of Medicine, New York City, USA, Cummins Paul ,   Ph.D., Icahn School of Medicine at Mount Sinai, New York City, USA, Rhodes Rosamond ,   Ph.D., Icahn School of Medicine at Mount Sinai; The Graduate Center, CUNY, New York City, USA
Published: September 2021

"Due to the COVID-19 pandemic, many courses that were once in person are now online. In our new “physically distanced” world, bioethics faculty has had to adapt quickly. To bridge the gap created by eliminating face-to-face interaction for two cohorts of international bioethics students, we combined them and created five four-week online bioethics mini-courses: “Justice and Pandemic Diseases,” “Reproduction,” “Pediatrics,” “Organ Transplantation,” and “Death and Dying.” Each mini-course involved required readings, weekly lectures, discussion board participation, and a final paper. Our study evaluates the comparative effectiveness of synchronous and asynchronous lecture delivery on student learning as evidenced in online discussion board posts in the mini-courses. Students from both cohorts received the same educational materials but were divided into two groups for alternating synchronous and asynchronous Zoom lectures. We developed a standardized rubric, and raters have been using it to score each student’s initial posts. We hypothesized that, for the same discussion board question, students’ scores on posts following synchronous lectures will on average be higher than those following asynchronous lectures. We will finalize our data analysis at the conclusion of the final mini-course in late March and learn if the data support our hypothesis. There are many challenges in determining the comparative effectiveness of synchronous and asynchronous teaching on overall student learning. Our study addresses a modest yet worthwhile question, whether and to what degree these different lecture modalities impact student learning evidenced in discussion board posts. Our findings will contribute to bioethics pedagogical research during these challenging times. "
AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN BELIMBING BESI (Averhhoa carrambola) PADA MENCIT (Mus musculus)
Authors: WIDI YANTHI NI PUTU SRI PUSPITA , Astiti Ni Putu Adriani , Sudatri Ni Wayan
Published: September 2021

Many antioxidant compounds, flavonoids, and saponins are contained in starfruit leaves (Averrhoa carambola). The purpose of this study was to determine the antidiabetic activity of star fruit extract in mice. This study used a completely randomized design (CRD) with 6 treatments, namely P1 (aquadest without alloxan) as a negative control, P2 (aquadest with alloxan) as a positive control, P3 (metformin 500 mg / kgBB), P4 (alloxan + ethanol extract of star fruit leaves. 100 mg / kgBB), P5 (alloxan + ethanol extract of star fruit leaves 150 mg / kgBB), P6 (alloxan + ethanol extract of star fruit leaves 200 mg / kgBB). The starfruit leaf extract was made using the maceration method. In order for experimental animals to become diabetic, alloxan is used at a dose of 120 mg / kgBW which is injected intramuscularly into the thigh muscles. After the experimental animals were diabetic, We were given ethanol extract of starfruit leaves according to the experimental design, starting from day 7th to day 21st. Blood glucose levels are measured with a glucometer every week. The results showed that the best decrease in blood glucose levels occurred in the first week and the second week. In the first week, the metformin treatment was able to reduce blood glucose by 88.4%, while the ethanol extract treatment of star fruit leaves at a dose of 200 mg / kg BW was able to reduce blood glucose levels by 60%. The ethanol extract of star fruit leaves has antidiabetic activity.

Keywords: mice, diabetes mellitus, blood glucose, starfruit leaves.
AKTIVITAS HARIAN DAN FREKUENSI BEGGING BEHAVIOUR DARI ELANG BONDOL (Haliastur indus) SITAAN DI PUSAT PENYELAMATAN SATWA, TABANAN, BALI
Authors: Widiyavedanta Gde Oka , Yuni Luh Putu Eswaryanti Kusuma , Ginantra I Ketut
Published: September 2021

Brahminy kite (Haliastur indus) is one of bird of prey species that occupy position as top predator. Many brahminy kite was captured and was kept as pet which caused those birds lose their ability to hunt as a result of being caged for too long and for not to be trained to hunt. In Bali Wildlife Rescue Centre, the confiscated brahminy kite showed begging behavior in which the birds “whine” every time a human approach. This kind of behaviour affect their readiness to be released in the wild. The purpose of this study was to determine the daily activity and the frequency of begging behaviour of confiscated brahminy kite in Bali Wildlife Rescue Centre. This study was conducted in January 2020. This study found that the brahminy kite at the Bali Wildlife Rescue Centre spent the most of their time for perching. The second highest activity was preening, whereas the least activities were feeding and moving.  The highest percentage to beg in brahminy kite was recorded in the morning, whereas the lowest percentage was in the midday. The results of this study indicate that the confiscated brahminy kite at the Bali Wildlife Rescue Centre still needs more time to be rehabilitated prior released ack into the wild.
PEMODELAN KASUS GIZI BURUK PADA BALITA DI PROVINSI BALI TAHUN 2018 MENGGUNAKAN REGRESI SPLINE
Authors: DANGIN NYOMAN KRISHNA PRATIWI , SRINADI I GUSTI AYU MADE , SUMARJAYA I WAYAN
Published: September 2021

Malnutrition associated with an unusual condition of the patient's nutritional status because the body weight index and age are not suitable, where body weight should be positively correlated with age. According to data from the Bali Health Department, malnutrition cases found in 2016 is 3,4% while in 2017 it founded 3,8%. This research uses spIine regression with malnutrition cases of children under 5 years old in Bali Province. To compare basis truncated spIine and B-SpIine, this study using the minimum value of Generalized Cross Validation (GCV) and Mean Square Error (MSE) of each basis. B-SpIine quadratic modeI with four knots is the best model.
PREDIKSI INFLOW DAN OUTFLOW UANG KARTAL DI PROVINSI BALI DENGAN METODE NEURO-FUZZY
Authors: YUSMANTARA I KADEK MENTIK , GANDHIADI G.K. , HARINI LUH PUTU IDA
Published: September 2021

In this paper, we present a novel approach to data-driven neuro-fuzzy modeling, which aims to create accurate monthly inflow and outflow forecast of money (M0) in Bali Province. The data is monthly time series included some religious ceremony identification variables and a monthly dummy variable from January 2011 to March 2019. Well known, Bali Province has unique cultures, the only one province which Hinduism majority religion in Indonesia, and listed as top tourism destination in the world. The neuro-fuzzy models were created using ANFIS architecture and sliding window time series analysis, then simulated using walk forward validation, interpreted using MAPE, and NRMSE. Based on the simulation of the last 24 months, the model of inflow obtained MAPE 23.33% (worth considering) and NRMSE 18.68% (accurate). Meanwhile, the model of outflow obtained MAPE 19.24% (accurate) and NRMSE 8.71% (very accurate). These models and their pieces of information could assist the central bank in Bali Province to prepare cash for money (M0) outflow and managed technic for counting money (M0) inflow.
APLIKASI ALGORITMA DIJKSTRA UNTUK MENENTUKAN RUTE TERPENDEK DARI KAMPUS A KE B UIN RADEN FATAH
Authors: SAPUTRAMA RENDI , HARTATIANA HARTATIANA
Published: September 2021

Finding the shortest direction is one of the options that have been considered while traveling. One of the problems that occur for lecturers, staff, and students of UIN Raden Fatah is determining the shortest direction from Campus A to B. The application of graph theory by using Dijkstra's Algorithm becomes a solution for this problem. This algorithm has the advantage to minimize the expense of the costs by finding the shortest route from starting point to the destination. This study is applied research. The study will discuss the determination of the origin and destination end-point, traverse route, the calculation of the weight distance, analyzes the Dijkstra's iteration to determine the shortest route, and conclusion. As the result, the land route becomes the shortest route option from UIN Raden Fatah Campus A to B. The directed graph of the route represents the location as point, the road as the side, and distance as weight. The result shows that the route distance is 6.94 km using Dijkstra's Algorithm.
Percepciones sociales frente al fenómeno de migración venezolana en una muestra de los habitantes de la ciudad de Sincelejo, Sucre, año 2019
Authors: Klimenko Olena , Peláez Stefanya , Pacheco Laura , Ríos Paternina Yuranys
Published: September 2021

Introducción: El fenómeno de migración venezolana ha producido un impacto en distintas esferas en la población colombiana, produciendo a menudo actitudes de rechazo y discriminación hacia la población migrante por parte de los habitantes nativos.Objetivo: describir las percepciones sociales de los habitantes de la ciudad de Sincelejo frente al fenómeno de migración venezolana durante el año 2019Método: En el estudio cuantitativo, no experimental expostfacto, de nivel descriptivo, participaron 100 habitantes de Sincelejo, la selección de la muestra se realizó de forma aleatoria mediante la encuesta realizada en las calles de la cuidad. Se empleo una escala Liker, diseñada ad hoc para el presente estudio, validad mediante el juicio de expertos y prueba piloto, obteniendo un alfa Cronbach de ,83.Resultados: Se observó una puntuación alta en la variable de infidelidad, lo cual revela una postura negativa y culpabilizante al respecto de los problemas en las relaciones amorosas de los habitantes encuestados, percibida a partir de la presencia de mujeres migrantes venezolanas, siendo ésta mas pronunciada en los participantes con los niveles educativos y estratos socioeconómicos mas bajos. Altos puntajes en la variable de seguridad ciudadana (mayor percepción de amenaza en los estratos socioeconómico más altos), orden público (mayor percepción de la amenaza en los estratos más bajos) y oportunidad de empleo (mayor percepción de la amenaza en los niveles educativos más altos), indican los habitantes encuestados perciben a los migrantes como una amenaza para su comunidad en estos aspectos. Igualmente, se encontraron puntajes medio altos en xenofobia, obteniendo el género masculino mayor puntajes en comparación con el femenino, al igual como participantes con un menor nivel educativo. También se encontraron niveles medio altos en el rechazo a los hábitos culturales de migrantes y tendencia de dominar por la fuerza la cultura ajena, lo cual no posibilita la integración pacifica de los migrantes a la comunidad receptora.Conclusiones: El estudio revelo una situación bastante preocupante al respecto de una actitud altamente negativa observada en los participantes del estudio hacia los migrantes venezolanos. se recomienda seguir en esta línea de investigación en otras poblaciones con el fin de buscar estrategias de abordaje para disminuir el impacto negativo de estas precepciones sociales en la población migrante y posibilitar una mejor y más inclusiva integración de estos en las comunidades de recepción.
Immune Cells Expansion From Peripheral Blood of Patients of Three Leading Cancers in Vietnam
Authors: Thao Chu Thi , Anh Bui Viet , Phong Nguyen Van , Kien Nguyen Trung , Tu Nguyen Dac , Hiep Doan Trung , Liem Nguyen Thanh , Nhung Hoang Thi My
Published: September 2021

Immunotherapy recently attracted the high attention of scientists in cancer treatment. However, this therapy is poorly studied and applied in Vietnam. In this report, we present the results of immune cell ex vivo expansion for cancer treatment. After 20-21 days of culture, the average number of CD3+CD8+ cytotoxic T lymphocytes (CTLs) increased by 633.6-fold, equivalent to 3277.5 × 106 cells, and with the cell viability was 96.3%. Among them, the increasing fold of lung, liver and gastric cancer patients were 232.4, 812.4 and 655.6 respectively. Meanwhile, the average number of CD3-CD56+ NK cells increased by 940.3-fold, equivalent to 2659.3 × 106 cells, with the cell viability of 95%. Gastric cancer patients had the highest fold of Natural killer (NK) cell expansion (1644.9 fold) compared to that in lung cancer (695.0 fold) and liver cancer patients (358.3 fold). These results revealed that our method of immune cell expansion met the requirements in the immune cell number for clinical applications in cancer treatment in Vietnam.
Ethanol Extract of Croton Kongensis Promotes Cell Cycle Arrest and Consequently Inhibits Anchorage-Independent Growth of Cervical Cancer Hela Cells
Authors: Loan Nguyen Thi Bich , Thanh Nguyen Lai , Duez Pierre , Thang Nguyen Dinh
Published: September 2021

Extracts from Croton kongenis present anticancer activities on various cancers. However, there is no research conducted to investigate the effects of Croton kongenis extracts on cervical cancer as well as on zebrafish. In this study, we demonstrated that Croton kongenis ethanol extract expressed high toxicity to cervical cancer Hela cells with an IC50 dose of 20.4 µg/mL and to zebrafish embryos with malformations, lethality and hatching inhibition at 72-hpf at effective dose of 125 µg/mL. Interestingly, treatment with Croton kongenis ethanol extract caused cell-cycle-arrest at the G2 phase. Particularly, percentages of Croton kongenis ethanol extract-treated cells in G1, S, G2/M were 70%, 6% and 23%, while percentages of control cells in G1, S, G2/M were 65%, 15% and 18%, respectively. Consistent with cell-cycle-arrest, the expressions of CDKN1A, CDNK2A and p53 in Croton kongenis ethanol extract-treated cells were up-regulated 2.0-, 1.65- and 1.8-fold, respectively. Significantly, treatment with Croton kongenis ethanol extract inhibited anchorage-independent growth of Hela cells; the number of colonies formed in soft-agar of Croton kongenis ethanol extract-treated cells was only one-fourth of that of control cells. In conclusion, we suggest that Croton kongenis ethanol extract could be able to use as a traditional medicine for treatment of cervical cancer.
Linguagem, cognição e ensino: Conceitos e possibilidades
Authors: d’Olivo Fernanda Moraes
Published: September 2021

A obra traz textos escritos por diferentes profissionais e pesquisadores que atuam na área da linguagem e que concentram suas reflexões na relação cérebro, linguagem, sujeito e ensino. Ao organizarmos esta obra, buscamos promover encontros entre estes profissionais, a fim de divulgar as pesquisas que discutem seriamente os temas propostos. Acreditamos que a leitura desta obra é fundamental para a formação de atuam ou atuarão tanto na área da linguagem quanto do ensino, para a compreensão dos processos relacionados à aquisição da fala e da escrita, em sujeitos com e sem diagnósticos relacionados ao aprendizado da língua. Consideramos relevante, também, dizer que nessa obra há textos que apresentam visões atuais e diferentes, mostrando a abertura para o diálogo de diferentes perspectivas teóricas. O esforço de promover este encontro reflete uma postura que acreditamos relevantes neste momento de ataque constante às ciências, em especial às ciências humanas.
“Filosofía” e “historia” en José Ortega y Gasset
Authors: Cebrecos Fermín
Published: September 2021

Cualquier reflexión sobre la filosofía de José Ortega y Gasset (1883-1955) debería llevarse a cabo, si se desea mantener fidelidad metodológica a su autor, no mediante una “vía recta” introductoria, sino —como se lee en ¿Qué es filosofía? [1929]— con “una táctica similar a la que los hebreos emplearon para tomar Jericó”: el “asedio”. Es decir: la adquisición de conocimiento sobre el objeto de reflexión solo se logrará procediendo lentamente mediante “giros concéntricos” y “circunnavegaciones” progresivas (Ortega, 2007, pp. 236-237, 245). Sin embargo, no será este el método de la presente contribución.
Confinamientos, contagios sobrenaturales y miedos reales: una lectura a partir de La cosa
Authors: Rivera Narváez Luis Felipe
Published: September 2021

La película La cosa de John Carpenter, realizada en 1982, es un referente de la ciencia ficción. A pesar de ser una película de otra época, dialoga con nuestro presente. Nos permite repensar ideas sobre una sociedad conflictuada, que padece una entidad que se transmite de un cuerpo a otro y que pone en juego su supervivencia.
Felizmente tú y contigo: a próposito de Happy Together y la soledad de a dos
Authors: Rojas Christopher
Published: September 2021

En una película como Happy Together (1997) de Wong Kar-wai (Shanghái 1958), se confirma la exterioridad del mundo interior: el universo gay debe buscarse tanto en lo físico como en las sensibilidades de sus protagonistas y, en último término, en los no lugares copados de ella.
Antes del k-pop: joyas del cine surcoreano
Authors: Esquives Carlos
Published: September 2021

Un viaje a décadas pasadas por zonas poco habitadas del cine de Corea del Sur con resultados satisfactorios que amplían el ya extenso horizonte de grandes películas de este país. Con temas que circulan entre la representación del ámbito rural, las costumbres patriarcales que decantan hacia el drama social o hacia el erotismo y fantasmas que respetan el folclore tradicional, tienen un telón de fondo que presenta secuelas de guerras que azotaron al país asiático.
Septostomy during laser surgery for twin-to-twin transfusion syndrome
Authors: Bugerenko Andrei E. , Shcherbakova Liya N. , Panina Olga B.
Published: September 2021

Aim. To assess the perinatal outcomes of monochorionic diamniotic (MCDA) pregnancy after fetoscopic laser coagulation of anastomoses (FLCA) performed for twin-to-twin transfusion syndrome (TTTS), accompanied by induced or unintentional septostomy, and to identify the factors leading to septostomy.
Materials and methods. The retrospective study included 231 cases of FLCA performed in pregnant women with TTTS: in 19 cases septostomy was performed, and in 212 cases intertwin membrane remained intact.
Results. The incidence of septostomy during FLCA for TTTS was 8.2%. In 47.3% the rupture of the intertwin membrane occurred during trocar insertion (unintentional septostomy); in 42.1% septostomy was needed to perform laser coagulation of anastomoses located on the placental surface in the donor's amnion (forced septostomy). The placenta was located on the anterior uterine wall in 78.9% in the septostomy group and in 47.6% with an intact intertwin membrane (p=0.01). Anastomoses were located on the donor half of the placenta significantly more often when septostomy was needed to perform selective coagulation of anastomoses located far from the intertwin membrane and obstructed by the body of the donor fetus (42.1%). In 15.8% of patients with septostomy and 2.4% with intact intertwin membrane, umbilical cords of the donor and the recipient fetus were attached closer than 2 cm to each other (p=0.003). In the septostomy group premature rupture of membranes was more frequent (42.1% vs 18.4%, p=0.03) and a delivery time was shorter [26.3 (18.0, 37.0) vs 34.4 (20.3, 40.0) weeks, respectively, p=0.01] than in patients with an intact intertwin membrane. The survival rate after FLCA was lower after septostomy compared to intact intertwin membrane: at least one of the twins survived in 47.4% vs 80.7%, respectively (p=0.002), both fetuses survived in 36.8% vs 75.0%, respectively (p=0.001). Logistic regression analysis showed increased risk of septostomy in patients with the anastomoses located on the donor half of the placenta and when the donor and the recipient umbilical cords are attached close to each other, regardless of the localization of the placenta, gestational age and the stage of TTTS.
Conclusion. Lower incidence of unintentional septostomy during FLCA achieved by using modern equipment and surgical techniques will lead to better perinatal outcomes in patients with MCDA twins with TTTS.
Important questions to ask when choosing hormonal contraception. Myths about contraception
Authors: Prilepskaya Vera N. , Bostandzhian Lana L.
Published: September 2021

Due to the introduction of modern methods of contraception in Europe and, in particular, in Russia, the abortion rate has decreased significantly. This is largely due to the use of such a progressive method as hormonal contraception. However, the level of use of modern methods of contraception in Russia remains low, which is often due to fear of side effects and existing myths, especially in relation to hormonal contraception. Combined oral contraceptives are well studied, have a favorable profile of efficacy and safety, the risks of taking them are minimal and are reflected in the instructions for use. When properly prescribed, hormonal contraception is a reliable method of protection against unwanted pregnancy, which also has additional benefits, including therapeutic effects.
Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
Authors: Dukhanin Aleksandr S.
Published: September 2021

The review considers features of iron and folic acid (FA) pharmacokinetics, which affect the effective micronutrient support: molecular mechanisms of absorption and distribution, homeostatic processes of maintaining plasma vitamin and mineral levels by the feedback mechanism, including by regulating the deposition. An important characteristic of ferrokinetics is the presence of unique iron exporter ferroportin which is controlled by a family of iron regulatory proteins. Systemic ferrotherapy and oral rout of iron delivery are distinguished. In general, parenteral iron preparation complexes consist of Fe(III) oxide/hydroxide core stabilized by a carbohydrate polymer shell. Once entering the bloodstream, iron complexes are absorbed by resident macrophages of the reticuloendothelial system of the liver, spleen and bone marrow. Systemic Fe(III) preparations are prodrugs, the active part of which, i.e. iron is released in the lysosomal matrix of phagocytes. Oral iron preparations are divided into those containing bivalent (ferrous) and trivalent (ferric) iron. The article discusses factors determining the differences in the absorption of oral ferrous and ferric iron preparation, the spectrum of side effects, as well as key pharmaceutical approaches to increase the tolerance and adherence of ferrotherapy. These include using preparations containing Fe(II) organic compounds that have a lower dissociation rate than inorganic iron salts as well as slowing down the release of the active Fe(II) pharmaceutical substance from the drug. The review pays special attention to folates as iron synergists and examines the features of FA pharmacokinetics, the molecular basis of synergism, and substantiates the use of combined iron and FA preparations.
The effectiveness of therapy for endometriosis-associated pelvic pain resistant to surgical treatment
Authors: Orazov Mekan R. , Radzinsky Viktor E. , Orekhov Roman E.
Published: September 2021

Aim. To assess the efficacy and safety of 24-week therapy with dienogest in patients with endometriosis-associated pelvic pain resistant to surgical treatment.
Materials and methods. The study included 126 patients aged 3340 years with external genital endometriosis (EGE) confirmed by laparoscopy and morphological examination (International classification of diseases, 10th revision [ICD-10] N80.1, 80.2, 80.3, 80.4) and with pelvic pain that occurred in 36 months after surgical treatment of EGE (ICD-10 N94.8 "Pain and other conditions associated with female genital organs and menstrual cycle"). The participants were stratified into 3 groups by pain syndrome severity according to the Verbal Analog Scale (VAS). The group-1 included patients with 1040 mm, the group-2 with 4170 mm, and the group-3 with more than 71 mm pain score according to VAS. Patients of all 3 groups were prescribed the denogest (Zafrilla, Gedeon Richter, 2 mg/day) for 24 weeks (according to the current pack insert). Follow-up and assessment of treatment outcomes were carried out over 6 months. Study design: prospective, observational, comparative study.
Results. In 3 and 6 months after the start of therapy, there was a stable statistically significant decrease in pain syndrome severity by all scales (Biberoglu Behrman Scale, Numeral Rating Scale, VAS) in each of the groups (p0.01). In all 3 groups, treatment led to an improvement in sexual function, assessed with the Female Sexual Function Index scale, in 3 and 6 months after the start of therapy (p0.01). According to the quality of life in endometriosis (Endometriosis Health Profile) questionnaire, the analyzed indicators significantly improved in all study participants (p0.01).
Conclusion. Dienogest is an effective and safe method for the treatment of endometriosis-associated pelvic pain resistant to surgical treatment. Treatment with dienogest for 24 weeks effectively relieves pain, improves symptoms, and improves quality of life and sexual functioning.
Development and Validation of UV Spectrophotometric Method of Mesalamine Using Hydrotropic Solubilizing Agents
Authors: Bhavani N. L. D.  , Gowtham Reddy Cheruku  , Bhargava Sri Harsha Polina  , Dheeraj Kotagiri  , Jnanendra Kumar Korukollu
Published: September 2021

The work was proposed to discuss method development and validation of the drug Mesalamine by using hydrotropic solubilizing agents. An uncomplicated, accurate, and precise method was developed for the drug Mesalamine in bulk as well as Pharmaceutical dosage form. 5M Urea was used as the hydrotropic solubilizing agent to enhance the solubility of the drug. The maximum wavelength (ʎ max) for Mesalamine was found to be 241nm. The validation was performed as per International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines for Accuracy, linearity, precision, Limit of detection (LOD) and Limit of quantification (LOQ). Percentage recovery (%) of Mesalamine was ascertained to be between 95 to 98%. Linearity for Mesalamine was observed between 2-10 µg/ml. Regression equation y=0.0571x-0.0186, regression coefficient (r²) is 0.9996 for Mesalamine. Inter day and intraday precision were checked, % relative standard deviation values were less than 2 for both the methods. Limit of detection (LOD) and Limit of quantification (LOQ) values were derived using regression equations. LOD value was found to be 0.55 µg/ml. LOQ value was found to be 1.67 µg/ml. The assay of the marketed formulation was performed and the results of the assay were obtained by the proposed method. The results are in between 98-102%. So, the method developed was simple and economical that can be adopted for routine tests.
POSSIBILIDADES DO USO DE OBRAS DE FICÇÃO CIENTÍFICA NO ENSINO DE FÍSICA
Authors: Sorensen Rafael do Nascimento , Teixeira Ricardo
Published: September 2021

Este artigo tem por finalidade analisar o uso de filmes e livros de ficção científica como recursos auxiliares para o ensino de física. Foram avaliadas diferentes possibilidades de inserção da ficção científica para estimular a motivação pela aprendizagem de temas científicos, bem como na contextualização de conceitos científicos em atividades educacionais abordando conteúdos relacionados tanto Ã  física básica, quanto Ã  física moderna e contemporânea, que estão presentes no currículo das escolas de ensino médio e em disciplinas de cursos superiores das áreas das ciências exatas. Inicialmente foi feita uma revisão bibliográfica a respeito de trabalhos de pesquisas já realizadas sobre este tema tanto no Brasil quanto em países estrangeiros. Foi feito também um estudo sobre a história da Ficção Científica, em busca de obras tanto bibliográficas quanto cinematográficas com um potencial para serem utilizadas no contexto do ensino de física. Certas obras de ficção científica foram escolhidas tendo em vista a potencialidade de utilização para auxiliar no ensino de física e na divulgação científica, tendo em vista também a possibilidade de incentivar jovens talentos para carreiras científicas. Algumas atividades de divulgação científica e oficinas didáticas foram realizadas e analisadas a partir de seus resultados.
Analysis of design of spacecraft solar arrays
Authors: Kazantsev Z. A. , Eroshenko A. M. , Babkina L. A. , Lopatin A. V.
Published: September 2021

Solar arrays supply electrical power to spacecraft equipment and also provide charging of electrochemical batteries used in the shadow sections of the orbit. Photovoltaic converters of light energy of solar radiation form the basis of the solar battery. Their principle of operation is based on the phenomenon of the photoelectric effect. The article provides an overview of the development of solar cells and the classification of modern designs of solar cells for spacecraft. The review considers stationary and deployable solar batteries used both on the first spacecraft and on space stations. The classification of solar cell designs is made taking into account their characteristic features. These features are the rigidity of the supporting structure, the method of placement in the starting position and the method of orientation towards the light source. The classification covered rigid panel solar arrays, flexible substrate solar panels, inflatable solar arrays, self-expanding solar arrays, and solar concentrator panels. In each design group of this classification, corresponding examples of solar cells are presented. The presented review and classification makes it possible to track trends in the development of solar array designs for spacecraft.
Analysis of the process of deployment of a lunar tether system taking into account the Earth's gravity
Authors: Ledkova T. A. , Zabolotnov Yu. M.
Published: September 2021

The development of space transport systems for the delivery of payloads and the study of the lunar surface is an important scientific and technical challenge. The article considers a near-lunar space tether system consisting of a station and a microsatellite. The station is considered as a rigid body having a cylindrical shape, and the microsatellite is considered as a spherical rigid body. The tether is considered as a weightless inextensible rod of variable length. The station moves in a near-lunar orbit, which is influenced by the Earth's gravity. The process of deployment of a radially directed near-lunar tether system is considered. The equations of motion of the space tether system are obtained using Newton's second law and the theorem on the change in the angular momentum. To release the tether and bring the orbital tether system to a working state, the article proposes to use the control program of tethers tension force, which ensures the deployment of the tether system to a position close to the vertical. A comparison of the motion of the tether system along the unperturbed lunar orbit and along the perturbed one, taking into account the gravitational influence of the Earth, is made. To substantiate the theoretical results, a numerical simulation was carried out, based on the results of which a conclusion was made about the influence of the Earth's gravity on the amplitude of oscillations of the microsatellite relative to the local vertical.
INSTITUTIONAL STRUCTURE OF THE MARKET OF MATERIAL AND TECHNICAL RESOURCES AND METHODOLOGICAL BASES OF RESOURCE EFFICIENCY ASSESSMENT
Authors:   Namangan Institute of Engineering and Technology of the Republic of Uzbekistan, Rahimov Bahromjon , Ibrokhimov Mirzobobur
Published: September 2021

The establishment of market relations in agriculture requires the development of the system of material and technical resources on the basis of market principles. Weak financial situation of agricultural enterprises, weakening of economic relations with the manufacturer of equipment, transport costs, transit, high customs duties, devaluation of money, imbalances between prices for agricultural and industrial products and a number of other factors.Keywords:regions, efficiency, economy, agricultural production, forecast, production potential, intensification, resources, economic mechanism.
ISSUES OF REASONABLE ORGANIZATION AND CONDUCT OF COST ACCOUNTING AND ANALYSIS IN ECONOMIC ENTITIES
Authors:   Tashkent state university of economics of the Republic of Uzbekistan, Mahmudov Azamat , Kenjaeva Farangiz ,   Tashkent State Transport University of the Republic of Uzbekistan
Published: September 2021

The article discusses the issues of accounting and analysis of the main production costs, period costs and costs of financial activities in the system of effective management of business entities. The influence of production processes on the perfect business operations is studied, proposals are givenand recommendations for the organization of primary and consolidated cost accounting are developed.Кеу words:production process, cost classification, primary and consolidated documentation, main activity, cost period, financial activity
CLUSTERING POLICY IN THE DEVELOPMENT OF THE TOURISM INDUSTRY OF UZBEKISTAN
Authors:   Syrdarya RegionalDepartment Agency for Youth Affairs, Tagaev Bekzod , Abduvokhidov Akmal Abdulazizovich ,   Gulistan State University of Uzbekistan
Published: September 2021

The tourism industry is the main source of employment, foreign exchange and tax revenues for developing countries. The flow of foreign currency income from tourism in developing countries far exceeds all aid flows from foreign donors.Today, there is an increasing need for scientific research that provides a basis for the further development of the global tourism sector, increasing its share in macroeconomic indicators, improving the use of tourist and recreational facilities in order to provide the population with newjobs in the regions of the country. In this regard, this article analyzes the role of cluster policy in the development of the tourism services market in our country.Keywords: tourism, tourism industry, tourism cluster, cluster policy, national economy, competitiveness of regions
OVERVIEW OF FOREIGN MODELS OF PERSONNEL MANAGEMENT
Authors:   Yeoju Technical Institute in Tashkent of the Republic of Uzbekistan, Olloberganova Raykhon
Published: September 2021

Methods for improving the personnel management system have been studied. The advanced foreign experience in the field of personnel management is analyzed. The structure of the human resources management system abroad is disclosed. The main schools of management are American and Japanese. The main trends in the development of personnel management systems in the United States are revealed. The main problems in the field of human resources management in Japan are analyzed.Keywords:world economy, USA, Japan, Personnel management, management.
METHODS AND POSSIBILITIES OF APPLYING CORPORATE GOVERNANCE IN THE COAL INDUSTRY
Authors:   Tashkent state technical university named Islam Karimov Of the Republic of Uzbekistan, Asimova Feruza
Published: September 2021

This article takes measures to further improve the production of coal products. Today, this serves to increase the efficiency of using energy resources in our country, providing its populationwith high-quality solid fuel.Keywords:coal industry, production infrastructure, diversification, modernization, logistics, high liquidity, monopoly products
Las respuestas relacionales derivadas como conducta aprendida
Authors:   University of Nevada, Reno, NV, United States, Hayes Steven C. , Fox Eric ,   University of Nevada, Nevada, NV, United States, Gifford Elizabeth V. ,   University of Nevada, Nevada, NV, United States, Wilson Kelly G. ,   University of Mississippi, Mississippi, United States, Barnes-Holmes Dermot ,   Ghent University, Ghent, Belgium, Healy Olive ,   National University of Ireland, Maynooth, Ireland
Published: September 2021

Las respuestas relacionales derivadas se presentan como una especie de grano o semilla de la que puede crecer un análisis de conducta del lenguaje y la cognición. Tiene una evidente similitud con los fenómenos del lenguaje, como, por ejemplo, en lo relativo a la bidireccionalidad entre palabras y referentes. Desde el punto de vista de la teoría conductual, las respuestas relaciones derivadas no son resultados que cabría esperar, y, por tanto, requieren de un análisis...
Hyperbolisation in the political discourse of D. Trump
Authors: Chebotar Tetyana
Published: September 2021

The article analyzes the peculilarities of hyperbolization as a characteristic rhetorical technique in the political discourse of Donald Trump, which was used by the politician with persuasive and manipulative purposes. The features of hyperbolized positive self-presentation in Trump's discourse were described, namely the use of numerous superlatives, positive evaluative constructions, lexical units with superlative semantics, emotionally-colored epithets and intensifiers when describing numerical values.
Efficacy and safety of hyperbaric oxygen treatment in SARS-COV-2 (COVID-19) pneumonia: a systematic review
Authors:   Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada, Boet Sylvain ,   Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada,   Francophone Affairs, Faculty of Medicine, University of Ottawa, Ottawa, Canada, Etherington Cole ,   Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada, Djaiani George ,   Department of Anesthesia and Pain Management, University Health Network, Toronto, Canada, Tricco Andrea C ,   Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Unity Health Toronto, Toronto, Canada,   Epidemiology Department and Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, Sikora Lindsey ,   Health Sciences Library, University of Ottawa, Ottawa, Canada, Katznelson Rita ,   Department of Anesthesia and Pain Management, University Health Network, Toronto, Canada
Published: September 2021

Introduction: The need for intubation and mechanical ventilation among COVID-19 patients is associated with high mortality rates and places a substantial burden on the healthcare system. There is a strong pathophysiological rationale suggesting that hyperbaric oxygen treatment (HBOT), a low-risk and non-invasive treatment, may be beneficial for COVID-19 patients. This systematic review aimed to explore the potential effectiveness and safety of HBOT for treating patients with COVID-19. Methods: Medline, Embase, Scopus, and Google Scholar were searched from December 2019 to February 2021, without language restrictions. The grey literature was searched via an internet search engine and targeted website and database searches. Reference lists of included studies were searched. Independent reviewers assessed studies for eligibility and extracted data, with disagreements resolved by consensus or a third reviewer. Risk of bias was assessed using the Newcastle Ottawa Scale. Data were summarised descriptively. Results: Six publications (one cohort study, five case reports/series) met the inclusion criteria with a total of 37 hypoxaemic COVID-19 patients treated with HBOT. Of these 37 patients, the need for intubation and mechanical ventilation and in-hospital survival were assessed for 26 patients across three studies. Of these 26 patients, intubation and mechanical ventilation were not required for 24, and 23 patients survived. No serious adverse events of HBOT in COVID-19 patients were reported. No randomised trials have been published. Conclusions: Limited and weak evidence from non-randomised studies including one propensity-matched cohort study suggests HBOT is safe and may be a promising intervention to optimise treatment and outcomes in hypoxaemic COVID-19 patients. Randomised controlled studies are urgently needed.