bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern Treatment Options for Epidermal Dysfunction at Atopic Dermatitis
Authors: Ambarchyan Eduard T. , Kuzminova Anastasiya D. , Ivanchikov Vladislav V.
Published: November 2023

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Its crucial component of pathogenesis is malfunction of the epidermal barrier. Filaggrin protein and associated mutations in the filaggrin gene play one of the key roles in this problem. Nowadays new topical products (emollients) has been created and implemented into practice with the aim of more personalized approach and increased therapy efficacy in patients with AD. Such drugs would allow us to restore epidermal barrier function and to achieve elimination of disease symptoms.
Dupilumab Efficacy and Safety in Severe Atopic Dermatitis in Children under 6 Years of Age: Two Clinical Cases
Authors: Murashkin Nikolay N. , Opryatin Leonid A. , Pavlova Ekaterina S. , Epishev Roman V. , Materikin Alexandr I. , Ivanov Roman A. , Savelova Alena A. , Leonova Maria A.
Published: November 2023

Background. Atopic dermatitis (AD) manifests during the first year of life in majority of all cases. The early disease onset is associated with the development of comorbid atopic conditions within the «atopic march» phenomenon. The AD pathogenesis is associated with genetic predisposition, epidermal barrier dysfunction, and immune dysregulation. T2-inflammation specifically determines the entire immune cascade of inflammatory reactions, and, thus, dictates the need of early drug intervention to modify the disease course. Clinical case description. This article presents two clinical cases of severe AD in children under 6 years of age. The treatment of both cases included genetically engineered biologic drug dupilumab. Continuous therapy for 4–5 months made it possible to relieve the skin manifestations of the disease.

Conclusion. AD, manifesting in infancy, is associated with high risk of developing other atopic spectrum diseases in older age. The timely onset of biological therapy allows us to affect immune dysregulation, and thereby to prevent the comorbid atopic conditions development.
Adalimumab Experience in the Management of Hidradenitis Suppurativa Burdened with Rapp-Hodgkin Syndrome
Authors: Murashkin Nikolay N. , Materikin Alexander I. , Epishev Roman V. , Leonova Maria A. , Opryatin Leonid A. , Fedorov Dmitri V. , Ivanov Roman A. , Savelova Alena A. , Katunina Oksana R. , Kulikov Kirill A. , Ufimtseva Anastasiya U.
Published: November 2023

Background. Rapp-Hodgkin syndrome is a rare genetic disease from the ectodermal dysplasia group. It manifests with damage of ectodermal structures — layer of embrional tissue that provides the development of many organs and tissues in the body, such as: skin, sweat glands, hair, teeth, and nails. Disease symptoms may range from mild to severe and include dental abnormalities, fragile, thin or no hair, abnormal nails, hypohidrosis (due to the reduced number of sweat glands), cleft lips and palate. Hidradenitis suppurativa is a chronic inflammatory disease that predominantly affects apocrine glands areas. This nosology is characterized by painful nodes, abscesses, and fistulas, prone to relapses and leading to scarring.

Clinical case description. The authors present a clinical case demonstrating the combination of Rapp-Hodgkin syndrome and severe hidradenitis suppurativa in 17-year-old male patient.

Conclusion. The heterogeneous clinical findings of hidradenitis suppurativa and history of rare genetic disease result in patients' admissions to various medical specialists. Thus, it leads to delayed verification of the diagnosis and incorrect treatment methods. As a result, patients have persistent cosmetic skin defects, possible complications of irrational treatment, and decreased quality of life by the time of diagnosis.
Skin Microbiome Composition and Key Factors of its Barrier Function
Authors: Murashkin Nikolay N. , Pavlova Ekaterina S. , Epishev Roman V. , Materikin Alexander I. , Ivanov Roman A. , Savelova Alena A. , Fedorov Dmitriy V. , Leonova Maria A.
Published: November 2023

The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection. The microbiome plays a crucial role in maintaining normal skin functioning: control of pathogenic diversity of microorganisms, stimulate immune cells, and modulate chronic dermatoses development. There are various mechanisms for restoring skin barrier function. They are associated with the microorganisms’ activity. Thus, skin restoration is an important task included in the general concept of atopic dermatitis management. One of such methods is the skin surface colonization with commensals, so significant role is assigned to the new dermatological drugs. The normalization of the microbiome in affected skin areas with cosmetic care products can significantly affect the result of skin barrier restoration.
Pemphigus Herpetiformis in Childhood: Clinical Case
Authors: Murashkin Nikolay N. , Materikin Alexander I. , Epishev Roman V. , Leonova Maria A. , Opryatin Leonid A. , Fedorov Dmitri V. , Ivanov Roman A. , Savelova Alena A. , Katunina Oksana R. , Kulikov Kirill A. , Yarullin Ilgiz I.
Published: November 2023

Background. Pemphigus herpetiformis is a rare atypical bullous dermatosis of autoimmune nature. It is characterized by rashes in the form of plaques with papules and vesicles at peripheral areas, or in the form of grouped papules, vesicles or tense bubbles with clinical similarity to During's herpetiformis dermatitis. Pemphigus herpetiformis diagnosis in pediatric practice is difficult due to the similarity of clinical manifestations to bullous dermatoses of other etiology, the rarity of the disease in children, and small number of scientific publications.

Clinical case description. Clinical case of pemphigus herpetiformis in a child is described. All necessary diagnostic algorithms for diagnosis and therapeutic tactics for patient management are presented. Dapsone and prednisolone were used as first-line drugs during the patient's treatment. They have shown its efficacy in management of such patients.

Conclusion. Differential diagnosis of pemphigus herpetiformis and other bullous dermatoses in children is presented. The results of successful drug treatment are shown.
Management and Prevention of Atopic Dermatitis Infectious Complications in Children
Authors: Epishev Roman V. , Materikin Alexander I. , Opryatin Leonid A. , Ivanov Roman A. , Leonova Maria A. , Savelova Alena A.
Published: November 2023

Atopic dermatitis (AD) is a chronic inflammatory skin disease with high risk of skin and systemic infections. Preventive AD therapy is based on skin barrier improvement and anti-inflammatory treatment, whereas, severe skin and systemic infections require systemic therapy. This review describes pathophysiology and possible treatment and prevention methods for AD infectious complications.
Ustrojowe implikacje obowiązywania zasady permanencji prac Sejmu i Senatu RP. Zarys problematyki
Authors:   Uniwersytet Rzeszowski, Pastuszko Grzegorz
Published: November 2023

The article is devoted to the issue of the principle of permanence of parliamentary work. It contains a general description of the principle in question and at the same time shows its importance for the functioning of state authority in Poland. Thanks to the analysis, the reader learns how permanence affects the implementation of some of the powers of the Sejm and Senate related to the performance of legislative, control and creative functions. He also gains knowledge on the extent to which it affects the relations between the Sejm and the Senate with other bodies, especially with the President and the Council of Ministers. The field of considerations designated in this way conceals the main research goal, which is to present the basic systemic consequences resulting from the introduction of the discussed formula of the work of representative bodies.
Konstytucyjne i ustawowe podstawy współpracy samorządów gminnych z organizacjami pozarządowymi w zakresie realizacji funkcji świadczącej wobec uchodźców wojennych z Ukrainy
Authors:   Wyższa Szkoła Gospodarki Euroregionalnej im. Alcide De Gasperi, Sitek Magdalena
Published: November 2023

The subject of the study is the performance of a providing function by communal governments in Poland in the context of the influx of war refugees from Ukraine in 2022. The work analyzes the legal basis for the operation of Polish local governments in this area. The author adopted as a research hypothesis the statement according to which the implementation of social assistance for war refugees from Ukraine was possible thanks to the cooperation of local governments with non-governmental organizations and parishes. The aim of the study is to show the need and effectiveness of cooperation between local governments and non-governmental organizations in Poland and parishes. The final conclusion of the study is the statement that thanks to the cooperation of local governments with non-governmental organizations and parishes, communal governments could better fulfill their function of providing services to people in need.
Rzetelne uzasadnienie wyroku sądowego w kontekście wyroku Europejskiego Trybunału Praw Człowieka z 9 marca 2023 r. w sprawie Cupiał przeciwko Polsce
Authors:   Uniwersytet Gdański, Gajda Agnieszka
Published: November 2023

One of the elements of the right to a fair trial is the right of the individual to a reliable justification of the decision in the case, derived from the right to the appropriate shap- ing of the court procedure. The aim of the article is to show that this is a key element in cases where the court adjudicates the rights and freedoms of an individual, setting their limits. In the judgment of March 9, 2023, in the case of Cupial against Poland, the Euro- pean Court of Human Rights emphasized the special role of a reliable justification of the judgment. The author considers this requirement as one of the fundamental guarantees of respecting the rights and freedoms of the individual, which in the context of the dis- cussed case is the freedom of conscience and religion, and the right to ensure children a religious upbringing in accordance with parents convictions. The analysis of the indi- cated issue was made on the basis of the dogmatic-legal method.
O znaczeniu konstytucyjnej zasady prawnej ochrony życia rodzinnego w procesie stosowania prawa
Authors:   Uniwersytet Szczeciński, Dadańska Katarzyna
Published: November 2023

The purpose of the article is to show the importance of the constitutional rule of legal protection of family life in the process of application of the law, during which the determination of the correct meaning of the norm of the law by means of a constitutional norm, is primarily important for a proper, pro-constitutional interpretation and ensures that the decision to apply the law, will be correct. The starting point for the research assumption will be an attempt to determine what designations constitute the concept of legal protection of the family, what provisions of the Polish Constitution implement this principle, and what is the function and subjective scope of this guarantee. The analysis will focus on selected provisions of the Polish Constitution and rulings of common courts, administrative courts, the Supreme Administrative Court and the Supreme Court, in which the discussed principle influenced the decision to apply the law.
American Progressivism and the U.S. Supreme Court Jurisprudence: Chinese Exclusion Cases – the Origins of the Doctrine of Consular Non-Reviewability
Authors:   Uniwersytet Warmińsko-Mazurski w Olsztynie, Sokalska Edyta
Published: November 2023

At the turn of the 19th and 20th centuries, the American reform movements tried to match American ideals with the challenges of the times. Progressive attitudes highlighted the necessity of reforms. The Chinese issue, often risen in the public dialogue, was the subject of deliberation of the Supreme Court, the Congress, and the federal executive branch of government. Chae Chan Ping v. United States and subsequent cases established the doctrine of consular noneviewability referring to immigration law and delineating the scope of judicial review for decisions concerning the admission of immigrants to the United States. They also strengthened the plenary power doctrine. We may ask if the Supreme Court judgments were in conformity with the ideas of American Progressivism. Unfortunately, the Chinese Exclusion Cases were not compatible with the visions of progressive reformers and reflected anti-Chinese sentiment rather than an aspiration for reforms.
Association between Comorbidities and COVID-19 Mortality: a Cross-Sectional Study in a Community Health Center in Indonesia
Authors: Sutaip Sutaip , Sutiningsih Dwi , Adi Mateus Sakundarno , Diyana Sutra , Rahayu Siti , Azizah Azzahra Nur , Andalusia Sarigando Banilai Putri , Giyantolin Giyantolin
Published: November 2023

Objective: To analyze the risk factors for mortality and comorbidity of COVID-19 patients in a public health center work area in Indonesia.Methods: This was a cross-sectional observational analytic quantitative study using secondary data of 820 confirmed COVID-19 cases in Brebes Public Health Center work area during the period of June 2020–December 2021. Univariate and bivariate analyses were used to analyze the obtained data statistically with a p-value of <0.005 considered significant.Results: Of the 820 confirmed COVID-19 patients, 85.1% recovered and 15.0% died. Analysis on the characteristics of these cases showed that 51.2% females and 48.8 %  males were included in this study, with 77.6% of them were <60 years old. No history of comorbidities was identified in 92.1% of the cases. In remaining cases with comorbidities, Diabetes Mellitus was recognized as the most prevalent (n=39, 4.8%).  Results of the Chi-Square test demonstrated that comorbidity status (p-value = 0.001), place of quarantine (p p=0.000 p>0.05), and diabetes (p=0.000, OR=2.87,  95% CI 19 1.24-0280) were significantly associated with mortality.Conclusion: Comorbidity status, diabetes, and the place quarantine are risk factors for mortality among COVID-19 confirmed cases, especially in Brebes Public Health Center work area. Thus, it is important to increase knowledge about COVID-19 prevention and risks to prevent transmission among those with higher risks for mortality. Further studies on factors related to sustainable supports for COVID-19 patients are also necessary.
Komplikasi Berat Pemasangan Central Venous Catheter: Serial Kasus
Authors: Muchtar Faisal , Adil Andi , Syukur Rusmin Bolo , Kusumanegara Jayarasti , Pangerang Andi Wija Indrawan
Published: November 2023

Kateter vena sentral/central venous catheter (CVC) diindikasikan untuk melakukan pemantauan terhadap tekanan vena sentral/central venous pressure (CVP), pemberian cairan untuk menangani hipovolemia dan syok, nutrisi parenteral dan untuk mendapatkan akses vena bagi pasien yang akses vena perifernya sulit didapatkan. Salah satu komplikasi pemasangan CVC yang paling umum adalah penusukan arteri yang dapat menyebabkan kondisi yang membahayakan jiwa. Laporan kasus ini menunjukkan keberhasilan penanganan syok hemoragik pascapemasangan CVC melalui resusitasi yang adekuat dan pembedahan endovaskular.
Desempenho resiliente ante período de crise econômica: Modelo integrado de concepções e estratégia de pesquisa
Authors: Rosa Leandro K. , Decourt Roberto F. , Vancin Daniel F.
Published: November 2023

Resumo Objetivo: Este estudo busca conceber um modelo integrado de concepções para pesquisas de resiliência organizacional ante período de crise econômica e sintetizar estratégia para abordagem empírica. Originalidade/valor: Ao reconhecer as recessões econômicas como eventos de crise, exógenos e recorrentes, que desafiam a trajetória evolutiva do ambiente de negócios e a capacidade adaptativa das firmas, este es-tudo se debruça sobre convergências de campos científicos para unificar ciclo de negócios com características e dinâmicas empresariais heterogêneas sob a perspectiva de resiliência. Design/metodologia/abordagem: Inicialmente, conduzimos revisão sistemática da literatura sobre “gestão do ciclo de negócios” e “resiliência organizacional”. Na sequência, usamos várias combinações e variações dos termos “crise econômica” e “resiliência”, acrescidos de “gestão” e “desempenho”, para ampliar a base de referências a partir de publicações em indexadores relevantes. Assim, mediante pesquisas de autores de diversas áreas do conhecimento, as proposições aqui levantadas se fundamentam na assimilação abrangente e transversal de saberes relativos ao contexto de crise econômica e de dinâmica adaptativa das organizações. Resultados: Este trabalho organiza e concilia convergências de campos científicos em um modelo integrado de concepções para estudo de resiliência organizacional ao longo dos ciclos de negócios, e, ainda, sintetiza a estratégia de pesquisa com três segmentos de análise para abordagem empírica. Assim, os achados cooperam com diversos fluxos de pesquisa que se voltam às adversidades enfrentadas pelas organizações em períodos de recessão e oportunizam amplo prisma de análise, com significativo espaço para explorar a vinculação de atributos e ações que favorecem ou prejudicam o alcance de desempenho resiliente ante período de crise econômica.
History of dental caries
Authors: Spielman Andrew I. , Forrai Judit
Published: November 2023

Dental caries is the single most common chronic childhood disease.
La gestión proyectual del diseño: aportes desde la comunicación el pensamiento visual y el pensamiento de diseño
Authors: Castellanos Escobar Alexis , Rodríguez Díaz Fabio Nelson
Published: November 2023

Este artículo presenta los resultados finales del trabajo de investigación La gestión de proyectos de comunicación: aportes desde el pensamiento visual y el pensamiento de diseño, cuyo objetivo principal consistió en identificar la importancia del pensamiento visual y el pensamiento de diseño en el planteamiento, estructuración, ejecución y evaluación de proyectos. En primer lugar presenta una breve contextualización del problema abordado, a través de ideas propias y de reconocidos autores. Posteriormente, se evidencia la metodología construida bajo un enfoque cualitativo, para la cual se utilizaron diferentes técnicas de recolección de la información como entrevistas a expertos en gestión de proyectos, grupos focales a los cuales se aplicaron herramientas de visión de proyecto y ruta de proyecto, para así apuntalar por la creación del Modelo de gestión proyectual E10 que finalmente, fue probado en talleres. Por último, el exto condensa los resultados y conclusiones entre las cuales se destacan la importancia de la comunicación en sus diversas manifestaciones (verbal, para-verbal, no-verbal, visual y escrita) en los procesos de gestión del actuar proyectual.
Maquinaria de punto: desarrollo y vigencia en el diseño actual
Authors: González Miriam-Luisa
Published: November 2023

Este artículo analiza la historia y la actualidad de la pequeña maquinaria de punto, su relación con la programación y las posibilidades de creación de motivos Jacquard. Se analiza cómo en los últimos años se ha revitalizado el uso de estas máquinas auspiciado por las relaciones colaborativas de usuarios en red y el interés por las producciones sostenibles, personalizables y de corta tirada. Por último, se propone un modelo para el diseño de patrones modulares para tarjetas perforadas apoyado en herramientas informáticas.
The effectiveness of interventions for improving the uptake of Intermittent Preventive Treatment (IPT) for malaria control among pregnant women in sub-saharan Africa: A systematic literature review
Authors: Chukwuma Ernest Egbujor , David Chinaecherem Innocent , Uchechukwu Madukaku Chukwuocha , Uzochukwu Godswill Ekeleme , John Chigozie Ekenze , Ugonma Winnie Dozie , Chiagoziem Ogazirilem Emerole , Igiri Vivian Chika , Nanush Damarlapally , Ihuoma Chimdimma Dike , Stanley Chinedu Eneh
Published: November 2023

Background: Malaria in pregnancy is a public health problem in Sub-Saharan Africa (SSA) that continues to account for increased morbidity and mortality among women. Anemia, maternal death, stillbirth, and low birth weight are complications associated with malaria in pregnancy. Adoption of recommended malaria control measures such as intermittent preventive treatment (IPT) remains a problem among pregnant women in SSA. Aim: We aimed to evaluate the effectiveness of interventions for improving the uptake of IPT for malaria control among pregnant women in SSA. Methods: The MEDLINE, Pub-Med CINAHL, and African Journal Online databases were subjected to a systematic search for Randomized Control Trials (RCTs) for the review. The studies were screened for eligibility and evaluated for methodological quality using the Cochrane Risk of Bias Tool. The screening process was carried out by one reviewer to help reduce the amount of time and resources that would have been used by two reviewers. The narrative synthesis approach was adopted for data analysis and synthesis after extraction from selected studies. Results: A total of 1679 articles were found, and the comprehensive screening of the search results left a total of four RCT studies that were deemed eligible for inclusion in the review. All the included studies adopted two-arm comparisons, i.e., the control and intervention groups. The findings revealed that three studies evidently reported increased uptake of intermittent preventive treatment in pregnancy using sulfadoxine-pyrimethamine (IPTp-Sp) doses among pregnant women following community-based promotional activities. Conclusion: Our review revealed the effectiveness of community-based promotional activities as effective interventions for improving uptake and possibly compliance to intermittent preventive treatment in pregnancy (IPTp) and antenatal attendance. This evidence and findings will guide policy-makers and health agencies in the SSA region to plan further interventions.
Remaining useful life prediction of equipment considering dynamic thresholds under the influence of maintenance
Authors: Li Kangning , Ren Li'na , Li Xueliang , Wang Ziqian
Published: November 2023

A novel approach for predicting remaining useful life (RUL) is proposed for situations where maintenance threshold and failure threshold exhibit dynamic behavior due to uncertainties in degradation and the influence of detection strategies during maintenance processes. The approach introduces maintenance threshold error to establish a multi-stage maintenance-impact degradation model with dynamic maintenance threshold based on the Wiener process. This model considers the impact of maintenance on degradation rate, amount, and path. Moreover, by using the first hitting time (FHT) and introducing failure threshold error to reflect the dynamic behavior of the failure threshold, the formula for predicting equipment RUL is derived. The model parameters are estimated using both the maximum likelihood estimation (MLE) approach and Bayesian formula. The proposed approach was validated with simulation data and gyroscope degradation data, and the results demonstrate its ability to effectively enhance the precision of equipment RUL prediction.
South Africa is in need of God’s Wisdom
Authors: Cornelius Elma M
Published: November 2023

In 2022, South Africa’s president was accused of corruption (Bloomberg, 2022). South Africa is in a deep political crisis and urgently in need of solutions as South Africans have had enough of the incompetence, indecency and selfishness that defines the leadership of the country (Brkic 2022). Theft, corruption, violence, murder, and other forms of crime in South Africa play a role in the crisis. Sociologist Heinecken (2020) says that violence is facilitated by lawlessness, corruption of the justice system, police brutality, and “an ideology that embraces … the use of violence as normal and desirable”. Psychologist Samenow (2022) says crime results from people’s thinking patterns. South Africa thus needs new thinking patterns. In 2012 (News24), former president Zuma acknowledged that South Africa needs wisdom. In 2016, after the “Save SA March”, SA religious leaders prayed inter alia for wisdom for South Africa (News24Wire 2016). South Africa is in dire need of wisdom. Wisdom is an attribute of God, and all human wisdom originates from God as His wisdom is a communicable attribute. Paul’s first letter to the Corinthians is addressed to a Christian church in Corinth with unique challenges in their community and Paul was angry with the Corinthians for clinging on to human wisdom and clinging on to immorality and conflict and disputes. In an argument in the letter-opening, Christ is presented by Paul as the wisdom of God. Paul states a contrast between human wisdom and the cross of Christ, between worldly patterns and the Christian message. What does God’s wisdom look like? James 3:17–18 gives seven characteristics of God’s wisdom: pure, peace-loving, considerate, submissive, full of mercy and good fruit, impartial and sincere. This article offers a reading of 1 Corinthians and James with a focus on God’s attribute of wisdom and how wisdom from God can benefit South Africans.
Reject, Reject, Reject...Passed! Explaining a Latecomer of Emigrant Enfranchisement
Authors: Finn Victoria , Ramaciotti Juan Pablo
Published: November 2023

Despite the extensive spread of external voting across the world, exceptions remain as some countries have not passed such regulations (e.g., Uruguay) or have passed them but lag implementation (e.g., Nicaragua). Others still took a long time to join the trend, possibly presenting a pushback to the commonly accepted notion of norm diffusion to explain migrant enfranchisement. We examine a latecomer by asking why Chile took so long to enfranchise emigrants. Classified as a liberal democracy with a century of legal history of foreign-resident voting, it repeatedly rejected proposed bills on external voting since 1971. Chile enacted external voting only in 2014, regulated it in 2016, and applied it in 2017. Through legal historical content analysis, we identify which political actors proposed the bills, when, and why each failed. Left and right-leaning actors gave normative, legal, and procedural reasons that resulted in rejection and stagnation at various institutional stages. This latecomer’s constitutional tradition, strongly focused on territory and territorial links, potentially sheds light on dozens of other country cases of late adoption of the external franchise.
Legitimisation of Foreign Direct Investment Screening Among Business Actors: The Danish Case
Authors: Nibe Anna Vlasiuk
Published: November 2023

There has been a conspicuous shift in the European Union’s perception of economic interdependence and open markets, manifested in a mushrooming number of screening policies aimed at verifying foreign direct investments raising national security concerns. The introduction of these policies can be viewed as a market constraint that might negatively affect business operations, so it is puzzling that some European business actors did not actively resist their adoption, despite having wide lobbying opportunities in Europe. I explore this puzzle using the case of Denmark by drawing on theories of securitisation and preference formation under uncertainty. I argue that business actors established their policy preferences in the context of uncertainty and the gradual increase in security framing by the European and local political elites. Exposed to these increasing security discourses across different levels and networks, businesses adjusted their policy preferences, balancing between different identities. The flexibility inherent in a multilevel and evolving securitisation process led to the legitimisation of investment screening policies among interest groups and mitigated their resistance to the imposition of market constraints on security grounds.
EU Renewable Energy Governance and the Ukraine War: Moving Ahead Through Strategic Flexibility?
Authors: Buzogány Aron , Ćetković Stefan , Maltby Tomas
Published: November 2023

When faced with highly heterogeneous national conditions and preferences, the EU has often resorted to differentiation to ensure political support for advancing common policies. Despite growing scholarly interest in differentiation in the EU, conceptual clarity and empirical evidence of different forms of differentiation are still in a nascent stage. Particularly the use of differentiation in times of crisis needs to be better understood. To address this research gap, we investigate differentiation in the EU renewable energy policy in response to the crisis stirred by Russia’s full-scale invasion of Ukraine. We find that the EU successfully used the Ukraine crisis to increase the ambition of renewable energy policy, but this was accompanied by various and often novel forms of differentiation. Rather than formally exempting countries from common EU provisions (differentiated integration), EU decision-makers strategically incorporated flexibility in implementation, often tailored to a few outlier countries. Strategic flexibility was instrumental in overcoming political disagreements among national governments and adopting a more ambitious and comprehensive renewable energy policy. Our findings contribute conceptually and empirically to understanding various forms of differentiation in EU policymaking and how they are employed to facilitate the building of political majorities during crises.
Comparing Hybrid Urbanisms in the Global South: Water Delivery Configurations in Peru and Ghana
Authors: Rosen Christian , Gribat Nina
Published: November 2023

Urban development processes in the Global South (and North) are often described as characterized by formal and informal practices of different actors and their respective material realities. In critical urban studies, the disposition for this binary conception of formal and informal urbanisms has been discussed for many years. To a certain extent, these sometimes align rather problematically with contrasting notions of the “structural” versus the “everyday.” In this article, we explore an understanding of formal and informal urban practices (and respectively “structure” and “everyday”) as always interrelated, and we develop a methodology for a comparative examination of such hybrid urbanisms. In doing so, we address a missing link in the surging theoretical debate on comparative/southern urbanisms, which has rarely been substantiated by methodological explorations. The adapted concept of “delivery configurations” combines analyses of actor networks, material realities, rules and regulations, discourses, and heterogenous arrays of urban practices of negotiating these. However, bringing together local particularities and structural commonalities and exploring their interrelation only provides a basis for understanding case-specific complexities. We argue that embedding the analysis in a multi-scalar comparative framework can further its analytical rather than descriptive attributes and provide deeper insights into issues such as social inequality. To illustrate our methodological contribution, we provide first insights from a comparative research project of water delivery in different neighbourhoods in the secondary cities of Sunyani (Ghana) and Arequipa (Peru). We highlight the practical challenges of comparing diverse urban contexts and examining the rather complex relationships between infrastructure delivery, urban development, and social inequality.
Preparation of Fibres from Urginea indica Kunth (Jangli Pyaz) and it’s Microbial Properties
Authors: Tripathy Parinita , Shahi Sanyogita
Published: November 2023

Urginea indica Kunth (Drimia indica), popularly known as Jangli Pyaz, is a rare, endangered, and threatened medicinal plant belonging to the Liliaceae family. It contains nutrients and beneficial compounds for your health. Onions have numerous papules in the bulbs that act as a defensive mechanism in addition to having a strong bitter flavour. Its mystical healing powers include cardiotonic, anti-carcinomic, anti-jaundice, anti-dropsy, anti-asthmatic, anti-epileptic, dermatological, and diuretic properties. It is also an abortifacient and has effects on the menstrual cycle. Insects, fungus, and rodents are all treated with it as a pesticide. There is a glaborous, bulbous plant known as Urginea indic. The Liliaceae family includes several therapeutic herb species. a Kunth in the forests of Maharashtra. Urginea indica Kunth bulb extracts' phytochemical analyses and antioxidant properties were evaluated. Bulbs are abundant in several primary and secondary metabolites, including sugars, alkaloids, vitamin C, vitamin E, flavonoids, phenols, glycosides, and saponins, according to phytochemical screening. An HPTL Catalysis method was developed for Urginea indica Kunth flavonoids' chemical fingerprinting. The method's accuracy, precision, and linearity were verified, and they were contrasted with those of the RP-HPLC-DAD method.
Relaxin as a biological marker and therapeutic target in heart failure
Authors: Alieva Amina M. , Reznik Elena V. , Baykova Irina E. , Teplova Natalia V. , Voronkova Kira V. , Kovtyukh Irina V. , Khadzhieva Nyurzhanna Kh. , Surskaya Elena V. , Kotikova Irina A. , Nikitin Igor G.
Published: November 2023

An important task of modern cardiology is the search and study of new cardiovascular biological markers that can help in the early diagnosis of heart diseases, serve as a tool to assess the effectiveness of treatment, and act as a prognostic marker and risk stratification criterion. This literature review aimed to consider relaxin (RLN) as a new diagnostic and prognostic cardiovascular biological marker. RLN is a natural peptide hormone with a molecular weight of approximately 6000 daltons. RLN2 is the main circulating form of RLN in the blood. Although human RLN2 was originally discovered as a hormone mainly secreted by the corpus luteum of the ovary, it is also synthesized in various tissues in non-pregnant women and men and is considered one of the most pleiotropic hormones of the human body, which perform various activities beyond reproduction.
The availability of serelaxin (a recombinant molecule identical to human RLN2) has made it possible to study the effects of RLN2 on the cardiovascular system, kidneys, liver, and brain and to evaluate it in several randomized placebo-controlled clinical trials. RLN2 exerts many cardioprotective effects on the heart and vessels and has been proposed as a therapeutic target for cardiovascular diseases such as heart failure, atrial fibrillation, coronary heart disease, myocardial infarction, and arterial hypertension. Through the activation of its cognate receptor and subsequent flow of several molecular signaling pathways in the cardiovascular system, RLN2 can induce vasodilation and angiogenesis, increase arterial compliance and cardiac output, reduce vascular resistance, exert antifibrotic effects through regulation and remodeling of extracellular matrix turnover, reduce inflammation and apoptosis, inhibit oxidative stress, induce chronotropic and inotropic effects, and inhibit ventricular and atrial ectopic activity.
Further studies are needed to demonstrate the potential use of RLN as an additional laboratory tool for diagnosis, risk stratification, and prediction of cardiovascular events in patients with heart failure. The effects of relaxin on morbidity and mortality in patients with heart failure have yet to be evaluated in more detail.
Analysis of the controlled essential hypertension’s pharmacotherapy in general practice
Authors: Slobodyanyuk Anatolii L. , Kupaev Vitalii I.
Published: November 2023

BACKGROUND: Arterial hypertension is a common cardiovascular disease that requires constant monitoring by a doctor of drug therapy to achieve the target blood pressure level.
AIM: To analyze pharmacotherapy of essential hypertension in patients, who have achieved a controlled course of the disease.
MATERIALS AND METHODS: In this study 274 patients with controlled course of stage 2 arterial hypertension and no comorbidities were recruited. Blood pressure indicators, anthropometric data, results of laboratory and instrumental studies, the volume of drug therapy for hypertension were analyzed.
RESULTS: We analyzed 543 drug prescriptions for 274 patients with stage II hypertension. In 97 (35.3%) patients only one drug was prescribed, in 112 (40.7%) two drugs, in 46 (16.7%) three drugs from various pharmacological groups, among which monodrugs were in the lead: angiotensin-converting-enzyme inhibitors 31.86%, cardioselective -blockers 23%, angiotensin 2 receptor blockers 9.3%. Combined drugs were present in 18.4% of general doctors prescriptions. Fixed forms of combined antihypertensive drugs were taken by only 50 (18.4%) patients. To prevent cardiovascular complications of arterial hypertension, 75 (26%) patients were prescribed statins (atorvastatin or rosuvastatin) and 56 (19.5%) antiplatelet monotherapy with Cardiomagnyl, Thrombo ACC or clopidogrel.
CONCLUSIONS: To achieve the target blood pressure level and control arterial hypertension in patients with stage II hypertension, general practitioners used all main
Entre la invisibilidad y la libertad: construir paz desde organizaciones LGBT en el norte del Cauca
Authors: Erazo-Gómez Alejandra , Martínez-Carrillo Hobeth , Palta-Calambas Luz Aleyda
Published: November 2023

This article discuss the close relationship between peace and the LGBT movement in Colombia. From a national perspective, the first LGBT and gender agenda for peace emerged through this community’s participation in the Caguán peace process. Sixteen years later, consolidated LGBT organizations had an impact on ensuring that the gender focus of the Havana agreement included them. At the local level, we will focus on the experience of the northern Cauca region from an intersectional perspective; there, rural LGBT organizations have consolidated since 2018. The analysis shows that this was made possible due to both the transition from war to peace and the autonomous and institutional strengthening of local activism. The research was carried out using a qualitative methodology that included fieldwork with national, regional, and local organizations, and a literature review.
Deformation Analysis in Aluminium Magnesium Alloy Using Digital Image Correlation
Authors: Tewari Kavita , Gwalani Rohit , Jain Preet , Sajin Rishabh , Sharma Srishti , Godse Atharva
Published: November 2023

Image processing is extensively used to examine surface deformations. Digital Image Correlation (DIC) detects two-dimensional subpixel displacements in two images to analyze deformations in geomechanical structures. In this study, the analysis is done on an aluminium-magnesium alloy. An optical microscope is used to capture the image, which is then processed and utilized to anticipate material deformation. To acquire findings of strain points on the material, the Ncorr application in the MATLAB environment is employed. . Strain graphs on the Exx, Exy, and Eyy axes, as well as U-displacement and V- displacement graphs, are generated to detect the deformation.
Biliary acids is a critical laboratory value in pregnant women: a case report as an opportunity to improve the quality of care
Authors: Montemari Anna Lisa , Carletti Michaela , Ferrero Susanna , Cristofaro Rosa Carmela , Di Felice Giovina , Callà Cinzia Anna Maria , Porzio Ottavia
Published: November 2023

Biliary acids (BA) levels were found greatly increased to 72.1 µM/l in a pregnant woman. Bambino Gesù Children’s Hospital had not established critical alarm values for BA, so communication of the result was overpassed. After 30 hours, the patient referred to the emergency room of another hospital for the assessment of the pregnancy course and BA re-evaluation, which in turn resulted normal. BA levels in our sample were re-analyzed in both laboratories and high levels were confirmed. We utilized an enzymatic cycling colorimetric method measuring primary, secondary and tertiary BA. The patient was on therapy with ursodeoxycholic acid (UDCA) explaining total BA results difference reported in the two different blood samples. BA accumulation maybe leads to fetal complications or loss and a quick communication of the result to clinician could potentially be life-saving for the baby. We implemented corrective actions to avoid adverse events by the introduction of a note on the report, warning of UDCA therapy interference in BA dosage and recommending the suspension of therapy 24 hours before blood sampling; furthermore, in order to provide high level of health care, we introduced an alarm value for fertile women in our critical values list.
EFEITOS DA DINÂMICA SOCIOECONÔMICA E A SEGREGAÇÃO SOCIOESPACIAL EM SALVADOR, BAHIA
Authors: Dias Gomes Julia , Couto Mello Marcia Maria
Published: November 2023

A produção do espaço urbano é um assunto debatido há décadas por diversos estudiosos. A configuração dos objetos na paisagem e seu comportamento na dinâmica espacial são de grande relevância para uma melhor compreensão do espaço. Compreender a dinâmica da cidade e da sociedade resulta na compreensão das características das cidades, bem como de seus agentes produtivos e produtores. Com isso, um dos fenômenos que afeta principalmente cidades subdesenvolvidas é a segregação socioespacial. Este estudo tem como objetivo investigar como a configuração da segregação socioespacial pode influenciar nas relações entre grupos distintos e classes sociais em Salvador. A partir dessa premissa, busca-se realizar a análise socioespacial, a partir da construção de um indicador socioeconômico. Os resultados permitem uma visualização de como a configuração sociespacial revela a forma de segregação, desigual e heterogênea em Salvador.
Methodology for Determining Emissions of Pollutants During the Life Cycle of Wind Power Plants by Aggregated Data
Authors: Mikheev P.Yu. , Fedorov M.P. , Chusov A.N. , Politaeva N.A.
Published: November 2023

The paper sets forth a new method for determining emissions of pollutant during the life cycle of wind farms by aggregated data. The rationale for the use of aggregated data is given. Within the framework of method, an algorithm was developed for determining the emissions of CO2eq, SO2eq and PO4eq in the production of elements of wind turbines and wind farms. Classification of elements of wind turbines by parameters and technical characteristics of elements with subsequent division into groups is given. Formulas for calculating emissions of pollutant at the stages of the wind farms life cycle are given and substantiated. Within the framework of the method testing, emissions of CO2eq, SO2eq and PO4eq were calculated during the life cycle of two onshore wind farms with an installed capacity of 70 MW with wind turbines, differing in the parameters and technical characteristics of the elements. Calculated emissions of pollutants, which can be prevented when choosing the wind farms as power sources and determined the environmental effect of their use when comparing with thermal power plants.
Thermal Processing of Solid Vegetable Waste by Slow Conductive Pyrolysis
Authors: Safin R.G. , Sotnikov V.G. , Ziatdinova D.F.
Published: November 2023

Pilot plants were developed to analyze heat and mass exchanges during the thermal decomposition of ligninocellulose. Methods of experimental research to determine the properties of thermal decomposition products were presented. Studies of thermal decomposition of plant raw materials for classical and high-temperature modes of slow pyrolysis were carried out. The pore structure of the obtained carbonate samples was studied. Optimal modes of slow conductive pyrolysis of vegetable raw materials were proposed. The paper presents the variant of industrial pyrolysis of plant waste into activated carbon.
ANÁLISE BIBLIOMÉTRICA: PROFISSIONAIS DA FRENTE DE LINHA DA SAÚDE E COVID-19 - ESTUDOS DO PERÍODO 2020-2021
Authors: Dos Santos Giovanna Melissa , Sanches Felipe Augusto Alves , Verlengia Rozangela
Published: November 2023

Objetivo: Realizar uma análise bibliométrica da literatura revisada por pares para identificar tendências das publicações sobre os profissionais da saúde da linha de frente da COVID-19. Métodos: O presente estudo é uma revisão bibliométrica. Para tanto, realizou-se busca na base de dados Web of Science de documentos publicados entre 2020 e 2021. Resultados: Foram encontrados 281 documentos, com uma taxa de aumento anual de 57,8%. Os tipos mais comuns de documentos foram artigos originais (n= 226) seguidos por documentos de revisão (n =37). As análises de rede das palavras-chave revelaram alta predominância de temáticas como ansiedade, depressão, estresse, equipamento de proteção individual, excesso de trabalho (burnout), insônia e estresse pós-traumático. Conclusão: Os achados revelam que a saúde mental dos trabalhadores da saúde na linha de frente da COVID-19 foi um tópico importante nos primeiros anos de pandemia e indicam uma necessidade de suporte psicológico a esses profissionais.
Development and characterization of a line with substitution of chromosome 4B of wheat Triticum aestivum L. on chromosome 4Hmar  of wild barley Hordeum marinum ssp. gussoneanum (4x)
Authors: Pershina L. A. , Trubacheeva N. V. , Shumny V. K. , Badaeva E. D.
Published: November 2023

Introgressive hybridization is the main method of broadening the genetic diversity of bread wheat. Wild barley Hordeum marinum ssp. gussoneanum Hudson (2n = 4x = 28) has useful agronomical traits, such as high resistance to stress factors, that could be a potential source of new genes for bread wheat improvement. This study aimed to evaluate the possibility of introgression of H. marinum chromosomes into the genome of bread wheat using an incomplete amphiploid H. marinum ssp. gussoneanum (4x)–T. aestivum (Pyrotrix 28) (2n = 54) carrying the cytoplasm of wild barley. For this purpose, we crossed the line of bread wheat variety Pyrotrix 28 with an incomplete amphiploid, and then selected cytogenetically stable 42­chromosome plants with a high level of fertility in hybrid progeny. Genomic in situ hybridization (GISH) revealed a pair of H. marinum chromosomes in the genome of these plants. C­ banding analysis confirmed that bread wheat chromosome 4B was replaced by wild barley chromosome 4Hmar. SSR markers Xgwm368 and Xgwm6 confirmed the absence of chromosome 4B, and EST markers BAWU808 and BAW112 identified chromosome 4Hmar in the genome of the isolated disomic wheat­barley substitution line. The study of this line showed that the substitution of chromosome 4B with chromosome 4Hmar resulted in a change of some morphological traits. It included intense anthocyanin coleoptile coloration, specific for H. marinum, as well as a lack of purple coloration of the ears in the leaf sheath, specific for Pyrotrix 28. Line 4Hmar(4B) showed increased performance for several traits, including plant height, number of spikes and tillers per plant, spikelet and grain number in the main spike, grain number per plant, but it had decreased values of 1000­grain weight compared to wheat. Cytogenetic stability and fertility of line 4Hmar(4B) indicated a high compensation ability of barley 4Hmar for wheat chromosome 4B and confirmed their homeology.