bluuebunny/crossref_metadata_2025 huggingface dataset:
UV and IR effects in axion quality control
Authors: Burgess C. P. , Choi Gongjun , Quevedo F.
Published: March 2024

Abstract

Motivated by recent discussions and the absence of exact global symmetries in UV completions of gravity we re-examine the axion quality problem (and naturalness issues more generally) using antisymmetric Kalb-Ramond (KR) fields rather than their pseudoscalar duals, as suggested by string and higher dimensional theories. Two types of axions can be identified: a model independent S-type axion dual to a two form Bμν in 4D and a T-type axion coming directly as 4D scalar Kaluza-Klein (KK) components of higher-dimensional tensor fields. For T-type axions our conclusions largely agree with earlier workers for the axion quality problem, but we also reconcile why T-type axions can couple to matter localized on 3-branes with Planck suppressed strength even when the axion decay constants are of order the KK scale. For S-type axions, we review the duality between form fields and massive scalars and show how duality impacts naturalness arguments about the UV sensitivity of the scalar potential. In particular UV contributions on the KR side suppress contributions on the scalar side by powers of m/M with m the axion mass and M the UV scale. We re-examine how the axion quality problem is formulated on the dual side and compare to recent treatments. We study how axion quality is affected by the ubiquity of p-form gauge potentials (for both p = 2 and p = 3) in string vacua and identify two criteria that can potentially lead to a problem. We also show why most fields do not satisfy these criteria, but when they do the existence of multiple fields also provides mechanisms for resolving it. We conclude that the quality problem is easily evaded.
Bootstrapping smooth conformal defects in Chern-Simons-matter theories
Authors: Gabai Barak , Sever Amit , Zhong De-liang
Published: March 2024

Abstract

The expectation value of a smooth conformal line defect in a CFT is a conformal invariant functional of its path in space-time. For example, in large N holographic theories, these fundamental observables are dual to the open-string partition function in AdS. In this paper, we develop a bootstrap method for studying them and apply it to conformal line defects in Chern-Simons matter theories. In these cases, the line bootstrap is based on three minimal assumptions — conformal invariance of the line defect, large N factorization, and the spectrum of the two lowest-lying operators at the end of the line. On the basis of these assumptions, we solve the one-dimensional CFT on the line and systematically compute the defect expectation value in an expansion around the straight line. We find that the conformal symmetry of a straight defect is insufficient to fix the answer. Instead, imposing the conformal symmetry of the defect along an arbitrary curved line leads to a functional bootstrap constraint. The solution to this constraint is found to be unique.
Reaction norm for genomic prediction of plant growth: modeling drought stress response in soybean
Authors: Toda Yusuke , Sasaki Goshi , Ohmori Yoshihiro , Yamasaki Yuji , Takahashi Hirokazu , Takanashi Hideki , Tsuda Mai , Kajiya-Kanegae Hiromi , Tsujimoto Hisashi , Kaga Akito , Hirai Masami , Nakazono Mikio , Fujiwara Toru , Iwata Hiroyoshi
Published: March 2024

Key message

We proposed models to predict the effects of genomic and environmental factors on daily soybean growth and applied them to soybean growth data obtained with unmanned aerial vehicles.

Advances in high-throughput phenotyping technology have made it possible to obtain time-series plant growth data in field trials, enabling genotype-by-environment interaction (G × E) modeling of plant growth. Although the reaction norm is an effective method for quantitatively evaluating G × E and has been implemented in genomic prediction models, no reaction norm models have been applied to plant growth data. Here, we propose a novel reaction norm model for plant growth using spline and random forest models, in which daily growth is explained by environmental factors one day prior. The proposed model was applied to soybean canopy area and height to evaluate the influence of drought stress levels. Changes in the canopy area and height of 198 cultivars were measured by remote sensing using unmanned aerial vehicles. Multiple drought stress levels were set as treatments, and their time-series soil moisture was measured. The models were evaluated using three cross-validation schemes. Although accuracy of the proposed models did not surpass that of single-trait genomic prediction, the results suggest that our model can capture G × E, especially the latter growth period for the random forest model. Also, significant variations in the G × E of the canopy height during the early growth period were visualized using the spline model. This result indicates the effectiveness of the proposed models on plant growth data and the possibility of revealing G × E in various growth stages in plant breeding by applying statistical or machine learning models to time-series phenotype data.
Mapping the landscape of product models in embodiment design
Authors: Paehler Lukas , Matthiesen Sven
Published: March 2024

During an engineering design process, designers create sequences of product models by switching between product models with different purposes. To enable an efficient use of these product models, researchers are required to anticipate the compatibility of the models in application by designers. This is necessary as the information in an existing product model may not be usable for a subsequent product model. However, the corresponding information on compatibility was not accessible to researchers as it was scattered across various publications. Hence, the objective of this contribution was to develop a structured overview, a landscape of linkable and non-linkable product models in embodiment design to merge the information. For this purpose, a literature review containing a grounded theory-based analysis was conducted and the results were visualized using the network visualization software Gephi. The key learnings of the visualized landscape of 52 product models can be summarized as follows: (1) some models are already closely linked to each other by compatible inputs and outputs; (2) other product models are noticeable with mostly unknown linking possibilities due to incompatible inputs and outputs or insufficient descriptions in the literature. 14 product models offer two linking possibilities or less. In these cases, it is unclear how they interact with other product models in an engineering design process. In conclusion, the product model landscape provides insight into the compatibility of product models to support the development of existing and new product models for sequential use by designers.
Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models
Authors: Zhu Yong , Meng Xiaoxiao , Zhu Xian , Zhang Jiaxiang , lv Hui , Wang Feiyao , Wang Jinfeng , Chen Cheng , Chen Mengting , Wang Dapeng , Jin Wei , Tian Rui , Wang Ruilan
Published: March 2024

Pulmonary fibrosis involves destruction of the lung parenchyma and extracellular matrix deposition. Effective treatments for pulmonary fibrosis are lacking and its pathogenesis is still unclear. Studies have found that epithelial-mesenchymal transition (EMT) of alveolar epithelial cells (AECs) plays an important role in progression of pulmonary fibrosis. Thus, an in-depth exploration of its mechanism might identify new therapeutic targets. In this study, we revealed that a novel circular RNA, MKLN1 (circMKLN1), was significantly elevated in two pulmonary fibrosis models (intraperitoneally with PQ, 50 mg/kg for 7 days, and intratracheally with BLM, 5 mg/kg for 28 days). Additionally, circMKLN1 was positively correlated with the severity of pulmonary fibrosis. Inhibition of circMKLN1 expression significantly reduced collagen deposition and inhibited EMT in AECs. EMT was aggravated after circMKLN1 overexpression in AECs. MiR-26a-5p/miR-26b-5p (miR-26a/b), the targets of circMKLN1, were confirmed by luciferase reporter assays. CircMKLN1 inhibition elevated miR-26a/b expression. Significantly decreased expression of CDK8 (one of the miR-26a/b targets) was observed after inhibition of circMKLN1. EMT was exacerbated again, and CDK8 expression was significantly increased after circMKLN1 inhibition and cotransfection of miR-26a/b inhibitors in AECs. Our research indicated that circMKLN1 promoted CDK8 expression through sponge adsorption of miR-26a/b, which regulates EMT and pulmonary fibrosis. This study provides a theoretical basis for finding new targets or biomarkers in pulmonary fibrosis.
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
Authors: Gokalp Dilan , Unal Gunes
Published: March 2024

Rationale

Ketamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and anesthetic effects in a dose dependent manner. It has a complex mechanism of action that involve alterations in other glutamate receptors. The metabotropic glutamate receptor 5 (mGluR5) has been investigated in relation to the psychotic and anesthetic properties of ketamine, while its role in mediating the therapeutic effects of ketamine remains unknown.

Objectives

We investigated the role of mGluR5 on the antidepressant, anxiolytic and fear memory-related effects of ketamine in adult male Wistar rats.

Methods

Two sets of experiments were conducted. We first utilized the positive allosteric modulator CDPPB to investigate how acute mGluR5 activation regulates the therapeutic effects of ketamine (10 mg/kg). We then tested the synergistic antidepressant effect of mGluR5 antagonism and ketamine by combining MTEP with a sub-effective dose of ketamine (1 mg/kg). Behavioral despair, locomotor activity, anxiety-like behavior, and fear memory were respectively assessed in the forced swim test (FST), open field test (OFT), elevated plus maze (EPM), and auditory fear conditioning.

Results

Enhancing mGluR5 activity via CDPPB occluded the antidepressant effect of ketamine without changing locomotor activity. Furthermore, concomitant administration of MTEP and ketamine exhibited a robust synergistic antidepressant effect. The MTEP + ketamine treatment, however, blocked the anxiolytic effect observed by sole administration of MTEP or the low dose ketamine.

Conclusions

These findings suggest that suppressed mGluR5 activity is required for the antidepressant effects of ketamine. Consequently, the antagonism of mGluR5 enhances the antidepressant effectiveness of low dose ketamine, but eliminates its anxiolytic effects.
Enhancing the purification of crocin-I from saffron through the combination of multicolumn countercurrent chromatography and green solvents
Authors: Hooshyari Ardakani Mohammad , Nosengo Chiara , Felletti Simona , Catani Martina , Cavazzini Alberto , De Luca Chiara , Rezadoost Hassan
Published: March 2024

Crocin-I, a valuable natural compound found in saffron (Crocus sativus L.), is the most abundant among the various crocin structures. Developing a cost-effective and scalable purification process to produce high-purity crocin-I is of great interest for future investigations into its biological properties and its potential applications in the treatment of neurological disorders. However purifying crocin-I through single-column preparative chromatography (batch) poses a yield-purity trade-off due to structural similarities among crocins, meaning that the choice of the collection window sacrifices either yield in benefit of higher purity or vice versa. This study demonstrates how the continuous countercurrent operating mode resolves this dilemma. Herein, a twin-column MCSGP (multicolumn countercurrent solvent gradient purification) process was employed to purify crocin-I. This study involved an environmentally friendly ethanolic extraction of saffron stigma, followed by an investigation into the stability of the crocin-I within the feed under varying storage conditions to ensure a stable feed composition during the purification. Then, the batch purification process was initially designed, optimized, and subsequently followed by the scale-up to the MCSGP process. To ensure a fair comparison, both processes were evaluated under similar conditions (e.g., similar total column volume). The results showed that, at a purity grade of 99.7%, the MCSGP technique demonstrated significant results, namely + 334% increase in recovery + 307% increase in productivity, and − 92% reduction in solvent consumption. To make the purification process even greener, the only organic solvent employed was ethanol, without the addition of any additive. In conclusion, this study presents the MCSGP as a reliable, simple, and economical technique for purifying crocin-I from saffron extract, demonstrating for the first time that it can be effectively applied as a powerful approach for process intensification in the purification of natural products from complex matrices.

Graphical Abstract
Weights for compact connected Lie groups
Authors: Kessar Radha , Malle Gunter , Semeraro Jason
Published: March 2024

Let $$\ell $$
ℓ
be a prime. If $$\textbf{G}$$
G
is a compact connected Lie group, or a connected reductive algebraic group in characteristic different from $$\ell $$
ℓ
, and $$\ell $$
ℓ
is a good prime for $$\textbf{G}$$
G
, we show that the number of weights of the $$\ell $$
ℓ
-fusion system of $$\textbf{G}$$
G
is equal to the number of irreducible characters of its Weyl group. The proof relies on the classification of $$\ell $$
ℓ
-stubborn subgroups in compact Lie groups.
Defining hip osteoarthritis feature prevalence, severity, and change using the Scoring of Hip Osteoarthritis with MRI (SHOMRI)
Authors: Heerey Joshua J. , Souza Richard B. , Link Thomas M. , Luitjens Johanna , Gassert Felix , Kemp Joanne L. , Scholes Mark J. , Crossley Kay M.
Published: March 2024

Objective

To define the reporting of Scoring Hip Osteoarthritis with MRI (SHOMRI) feature prevalence and severity, and to develop criteria to monitor feature change in longitudinal investigations.

Methods

Twenty-five participants (50 hips) of the femoroacetabular impingement and hip osteoarthritis cohort study underwent baseline and 2-year follow-up 3 T hip MRIs. Eight hip OA features were assessed using the SHOMRI. All MRIs were read paired with knowledge of timepoint by two blinded musculoskeletal radiologists. We provide definitions to report SHOMRI feature prevalence, severity, and longitudinal change.

Results

We report clear definitions for SHOMRI feature prevalence, severity, and change. When we applied the definitions to the studied cohort, we could detect the prevalence, severity, and change of hip OA features. For example, 88% of hips had labral tears (34% graded as severe tears) and 76% had cartilage defects (42% graded as full thickness). Over 70% of hips had feature change over 2 years, highlighting the sensitivity of SHOMRI definitions to assess longitudinal change of hip OA features. Intra-reader reliability was almost perfect (weighted (w)-kappa 0.86 to 1.00), with inter-reader reliability substantial to almost perfect (w-kappa 0.80 to 1.00).

Conclusion

This study is the first to provide definitions to report SHOMRI feature prevalence, severity, and change. The proposed definitions will enable comparison between hip MRI studies and improve our understanding of hip OA pathogenesis.
Hypertrophied medial parapatellar plica: a case of a medial plica anatomical variation with insertion to the inter-meniscal ligament in an adolescent athlete treated arthroscopically
Authors: Vasiliadis Angelo V. , Koukoulias Nikolaos E. , Dimitriadis Theofilos , Totlis Trifon
Published: March 2024

Purpose

The present study aims to report the arthroscopic, radiological and clinical appearance of a rare anatomical variation of a hypertrophied medial parapatellar plica with its response to arthroscopic treatment.

Case presentation

A 14-year-old female handball athlete presented with a history of left knee injury during her participation in a handball training session and subsequent locked knee at 20º flexion. Tenderness was located at the medial joint line. Plain radiographs of the injured knee were normal. The magnetic resonance imaging revealed a hypertrophic medial parapatellar plica and a horizontal tear of the medial meniscus. A standard knee arthroscopy was performed. An extremely hypertrophied medial plica was identified, covering a great part of the medial femoral condyle extending up to the femoral trochlea. Distally, it was attached into the inter-meniscal ligament. The plica was excised and the medial meniscus tear was repaired. At 1-month post-operatively, the patient was completely asymptomatic and at 3-months she returned to her weekly training routine.

Conclusions

This study presented a rare anatomical variation of a hypertrophied medial parapatellar plica with atypical course in the medial patellofemoral compartment and insertion into the inter-meniscal ligament. In combination with a medial meniscus tear led to a locked knee. Arthroscopic medial meniscus repair and plica excision resulted in complete resolution of symptoms.
Prenatal diagnosis of intrathoracic kidney and adrenal gland in left-sided congenital diaphragmatic hernia
Authors: Tian Tian , Chen Huizhu , Tang Jing , Luo Hong
Published: March 2024

A 29-year-old primigravida at 31 weeks of gestation was referred for intrathoracic kidney (ITK). Ultrasound revealed left kidney intrathoracic placement with an anteriorly positioned ectopic adrenal gland. Magnetic resonance imaging confirmed diaphragmatic interruption and colon herniation. A female neonate, delivered at 37 weeks, underwent successful thoracoscopic repair for a left Bochdalek hernia. Despite compression of the left lung, notably optimistic lung-to-head ratio (LHR) values were observed, correlating with favorable outcomes. This case underscores the rare occurrence of ITK, its association with Bochdalek hernia, and the importance of comprehensive prenatal evaluations.
Exploring nexus policy insights for water-energy-food resilient communities
Authors: Adamos Giannis , Caucci Serena , Charpentier Löic , Chediek Juliana , Krol Durk , Laspidou Chrysi
Published: March 2024

This paper provides a non-exhaustive overview of the main policies of the European Green Deal from the perspective of the water, energy and food Nexus, seeking for correlations, developments, actions and commandments that are intended to fulfil the prognoses designed by the Agreement., It covers the main public policies being implemented in the fields of water, energy and food in order to address any interlinkages among the policies already applied under a Nexus approach. The paper also points out some considerations over the European Union’s legal framework into the Nexus for water-related challenges’ perspectives. The goal is to facilitate the collaboration with stakeholders to gain deeper insights into how the interconnected relationship between water, energy, and food promotes policy alignment in the realms of these resources, facilitating Europe's shift towards a circular and eco-friendly economy.
Variables controlling growing season carbon dynamics in desert shrub ecosystem
Authors: Şaylan Levent , Kimura Reiji , Başakin Eyyup Ensar , Kurosaki Yasunori
Published: March 2024

Arid and semi-arid lands (drylands) are under the influence of extreme environmental conditions and cover large areas on Earth’s land surface. Determining temporal and spatial variations of the greenhouse gas and energy exchange in these ecosystems will provide a better understanding of both, the dynamics between the drylands’s surface and the atmosphere and the importance in climate change. In this study, CO2 exchanges over a shrub steppe ecosystem were determined using the Eddy Covariance method during both dry and wet growing seasons in the Gobi Desert, Mongolia. The net ecosystem exchange (NEE) was modeled using the extreme gradient boosting method (XGBOOST). Variables influencing NEE were estimated employing the SHapley Additive exPlanations algorithm (SHAP). The XGBOOST predictions demonstrated impressive results across all growing seasons, with high performance metrics (R2 = 0.821; NSE = 0.817), particularly notable during the wet season (R2 = 0.932; NSE = 0.929). The total NEE changed between 79.7 and -110.4 gC m−2 throughout the growing seasons. Especially the precipitation before the growing period has a positive impact on carbon sequestration in the shrub ecosystem in the following dry season. A high similarity was found in the patterns of daily NEE of all growing seasons and normalized difference vegetation index (NDVI), albedo, soil water content, temperature, sensible heat flux, the difference between air and soil temperature in desert shrub ecosystem. Although NDVI was the dominant factor during the wet season, there was a weaker relationship between these factors and NEE in the dry season than in the wet season.
Assessment of air pollution emitted during cooking using biomass and cleaner fuels in the Shiselweni region of Eswatini (Swaziland)
Authors: Neumann Melinda , Dlamini Wonder Nathi , Sallah-Ud-Din Rasham , Berekute Abiyu Kerebo , Siregar Sepridawati , Getnet Mastewal Endeshaw , Maulana Muchsin , Pan Wen-Chi , Lung Shih-Chun Candice , Yu Kuo-Pin
Published: March 2024

In Eswatini, 62.3% of households still rely on solid fuel for cooking, especially wood (61.8%). Smoke emissions during biomass burning remain the primary source of indoor air pollution, comprising pollutants detrimental to health. This study provides a quantitative exposure assessment of fuels used in the Shiselweni region with the objectives of monitoring the carbon monoxide (CO) and carbon dioxide (CO2) concentrations during cooking events and evaluating cancer and noncancer risks due to exposure to particulate-bound polycyclic aromatic hydrocarbons (PAHs) during cooking events among cooking personnel in households that cook indoors by burning biomass. Real-time CO, CO2, and particulate matter (PM) monitoring was performed in seventeen kitchens during cooking events across the Shiselweni region using different cooking methods: biomass in open fires and stoves, liquefied petroleum gas (LPG), and electric stoves. PM2.5, PM10, and CO exceeded indoor exposure guidelines for biomass fuel-related homesteads. Particulate PAH intake concentrations were evaluated, and biomass fuel users exhibited high cancer risks and low embryo survival chances due to particulate PAH exposure. The average total cost of reducing the incremental lifetime cancer risk (ILCR) and hazard quotient (HQ) to acceptable levels was lower when shifting from biomass to LPG stoves than when shifting to electric stoves.

Graphical abstract
Disassembly line optimization with reinforcement learning
Authors: Kegyes Tamás , Süle Zoltán , Abonyi János
Published: March 2024

As the environmental aspects become increasingly important, the disassembly problems have become the researcher’s focus. Multiple criteria do not enable finding a general optimization method for the topic, but some heuristics and classical formulations provide effective solutions. By highlighting that disassembly problems are not the straight inverses of assembly problems and the conditions are not standard, disassembly optimization solutions require human control and supervision. Considering that Reinforcement learning (RL) methods can successfully solve complex optimization problems, we developed an RL-based solution for a fully formalized disassembly problem. There were known successful implementations of RL-based optimizers. But we integrated a novel heuristic to target a dynamically pre-filtered action space for the RL agent (dlOptRL algorithm) and hence significantly raise the efficiency of the learning path. Our algorithm belongs to the Heuristically Accelerated Reinforcement Learning (HARL) method class. We demonstrated its applicability in two use cases, but our approach can also be easily adapted for other problem types. Our article gives a detailed overview of disassembly problems and their formulation, the general RL framework and especially Q-learning techniques, and a perfect example of extending RL learning with a built-in heuristic.
Molecular detection of herpesvirus in a skin lesion of a humpback whale (Megaptera novaeangliae) from the Western Mediterranean Sea
Authors: Vargas-Castro Ignacio , Crespo-Picazo José Luis , Jiménez Martínez Mª Ángeles , Muñoz-Baquero Marta , Marco-Cabedo Vicente , García-Párraga Daniel , Sánchez-Vizcaíno José Manuel
Published: March 2024

Herpesvirus has the potential to infect a wide variety of animal species. In cetaceans, Alpha- and/or Gammaherpesvirinae have been identified in eight families of odontocetes, and one family of mysticetes. In May 2022, an adult humpback whale (Megaptera novaeangliae) was found stranded in Valencia, Spain. The whale was emaciated, in poor body condition, with multiple lacerations on the dorsal fin and a high number of epibionts of the Cyamidae family, known as whale lice. The individual had been previously released from a ghost net entanglement 5 days before becoming stranded. In a closer examination, various skin lesions were observed, including chronic, proliferative, and erosive dermatitis and a large ulcer extending to the deep dermis. As part of the infectious disease surveillance programme, molecular testing was performed on skin samples for herpesvirus, cetacean morbillivirus, and poxvirus. A positive result for herpesvirus was obtained from one of the skin lesions. The sequence was found to belong to the Alphaherpesvirinae subfamily, and it was closely related to alphaherpesvirus sequences from a fin whale (Balaenoptera physalus) and a humpback whale. Cetacean morbillivirus and poxvirus testing was negative. To the authors’ knowledge, this is the first report of herpesvirus in a humpback whale from the Mediterranean Sea. Reports on herpesvirus detection or infection in humpback whales (only species within the genus Megaptera) are scarce. In consequence, future virological assessments of humpback whales should include testing for herpesvirus.
On the Micro-Stress Fields in Fibre-Hybrid Polymer Composite Laminae with Periodic Microstructure Under Transverse Tension and Transverse Shear Loading
Authors: Romano G. , Rao Y. N. , Liu C. , Katnam K. B. , Zou Z. , Potluri P.
Published: March 2024

This paper investigates the effect of intra-laminar fibre hybridisation, i.e., primary and secondary fibres within a matrix, on the homogenised properties and micro-stress fields in uni-directional polymer composite laminae. The study is focused on S-glass/epoxy laminae which are hybridised with secondary fibres (e.g., polypropylene). Two-dimensional repeating unit cells (2D RUCs) with periodic microstructures are developed to conduct the micro-mechanical analyses under transverse tensile and transverse shear loading conditions. Uni-directional fibre-hybrid S-glass/epoxy laminae with different secondary fibres are studied by varying (a) the periodic microstructure and (b) the material properties of the constituent fibres to assess the effect of such geometric and material variations on the homogenised elastic lamina properties and intra-lamina micro-stress fields. The results show that intra-laminar fibre hybridisation significantly affects the elastic lamina properties and micro-stress fields. Notably, the presence of the secondary fibres significantly increases or reduces the stress fields in the matrix and at the fibre-matrix interfaces (i.e. normal and shears stress components)–depending on the microstructure and the stiffness of the secondary fibres–which could be explored to manipulate the damage modes and thus energy dissipation mechanisms.
Permafrost degradation and its consequences for carbon storage in soils of Interior Alaska
Authors: Liebmann Patrick , Bárta Jiří , Vogel Cordula , Urich Tim , Kholodov Alexander , Varsadiya Milan , Mewes Ole , Dultz Stefan , Waqas Muhammad , Wang Haitao , Shibistova Olga , Guggenberger Georg
Published: March 2024

Permafrost soils in the northern hemisphere are known to harbor large amounts of soil organic matter (SOM). Global climate warming endangers this stable soil organic carbon (SOC) pool by triggering permafrost thaw and deepening the active layer, while at the same time progressing soil formation. But depending, e.g., on ice content or drainage, conditions in the degraded permafrost can range from water-saturated/anoxic to dry/oxic, with concomitant shifts in SOM stabilizing mechanisms. In this field study in Interior Alaska, we investigated two sites featuring degraded permafrost, one water-saturated and the other well-drained, alongside a third site with intact permafrost. Soil aggregate- and density fractions highlighted that permafrost thaw promoted macroaggregate formation, amplified by the incorporation of particulate organic matter, in topsoils of both degradation sites, thus potentially counteracting a decrease in topsoil SOC induced by the permafrost thawing. However, the subsoils were found to store notably less SOC than the intact permafrost in all fractions of both degradation sites. Our investigations revealed up to net 75% smaller SOC storage in the upper 100 cm of degraded permafrost soils as compared to the intact one, predominantly related to the subsoils, while differences between soils of wet and dry degraded landscapes were minor. This study provides evidence that the consideration of different permafrost degradation landscapes and the employment of soil fractionation techniques is a useful combination to investigate soil development and SOM stabilization processes in this sensitive ecosystem.
Trapped in an Abusive Relationship with an Organized Crime Offender: the Importance of Mental Health Support
Authors: Hoeboer Chris M. , Bakker Anne , Wijn Remco , Kallen Victor , Olff Miranda
Published: March 2024

This study aims to get more insight into experiences in the process towards mental recovery and the feasibility of providing mental health support to victims of intimate partner violence (IPV) committed by organized crime offenders in The Netherlands. 150 female victims were identified and, when reached, offered the option for safe and anonymous mental health support for their trauma-related symptoms. We used a mixed-method design involving information from police files (n = 150), patient files (n = 7), focus groups with therapists involved in the mental health support program (n = 4) and in-depth interviews with patients themselves (n = 4). Results showed that participants in the interviews experienced many mental health complaints, but limited access to mental health support. They were trapped in a relationship characterized by violence, psychological warfare and a forced dependency. All interviewed participants were isolated from social support and society in general. Escaping the criminal partner was extremely difficult and even when the participant successfully regained some form of independency, true separation appeared to be almost impossible. The participants felt little support from governmental and non-governmental aid organisations in this process. The mental health support in the current project proved challenging but feasible. Findings suggest that victims of IPV committed by organized crime offenders urgently need professional help. Actions to ensure their safety and to overcome barriers that hamper access to aid organizations are required.
Physical, Chemical and Compaction Characteristics of Slightly Weathered Tephras of New Zealand
Authors: Sood Shaurya , Chiaro Gabriele , Wilson Thomas , Stringer Mark
Published: March 2024

The North Island of New Zealand is a region of high volcanic activity, with significant eruptions over the past. Analogous to past events, future volcanic eruptions would produce a considerable volume of ash and granular soils, covering widespread areas and raising concerns for their disposal and storage. Such deposits, primarily airfall tephra, could be potentially used in geotechnical engineering applications such as foundations, roadway embankments and land reclamations. However, before their use as structural fills can be recommended, detailed laboratory investigations of their physical, chemical, compaction, and geotechnical engineering properties (strength, compressibility, collapsibility, liquefaction potential, etc.) must be conducted. Different tephra deposits can be products of different eruptions, so chemical composition analyses can be combined with the physical, compaction, and engineering properties to characterize such deposits. Accordingly, this paper provides useful insights from physical (grain size, specific gravity, and morphology), chemical (elemental and mineralogy using X-ray fluorescence and X-ray diffraction), and compaction tests (maximum dry density, optimum water content, and particle breakage) for eleven selected volcanic tephra samples sourced from the North Island of New Zealand in the Rotorua, Taupo, and Auckland regions.
Collapse Studies in Archaeology from 2012 to 2023
Authors: Middleton Guy D.
Published: March 2024

The study of collapse in archaeology and history has continued to grow and develop in the last decade and is a respectable target of investigation in and beyond these fields. Environmental determinism and apocalyptic narratives have become less acceptable and collapsology has matured into a more nuanced, self-critical, and sophisticated field. This review explores recent work on collapse in archaeology between 2012 and 2023. It demonstrates how collapse, and associated concepts such as resilience, fragility, and vulnerability, are studied in the light of present-day threats, how collapse studies are increasingly recognized to have application in the present day, where they can contribute to discourses of resilience and sustainable development, and shows the diversity present in collapse studies. It also discusses the language and concepts of collapse. I explore these areas with reference to general works on collapse and to six specific historical episodes of collapse: Old World collapse, eastern Mediterranean collapse, the Western and Eastern Roman Empires, the Classic Maya, Tiwanaku, and Rapa Nui.
Cloud media video encoding: review and challenges
Authors: Moina-Rivera Wilmer , Garcia-Pineda Miguel , Gutiérrez-Aguado Juan , Alcaraz-Calero Jose M.
Published: March 2024

In recent years, Internet traffic patterns have been changing. Most of the traffic demand by end users is multimedia, in particular, video streaming accounts for over 53%. This demand has led to improved network infrastructures and computing architectures to meet the challenges of delivering these multimedia services while maintaining an adequate quality of experience. Focusing on the preparation and adequacy of multimedia content for broadcasting, Cloud and Edge Computing infrastructures have been and will be crucial to offer high and ultra-high definition multimedia content in live, real-time, or video-on-demand scenarios. For these reasons, this review paper presents a detailed study of research papers related to encoding and transcoding techniques in cloud computing environments. It begins by discussing the evolution of streaming and the importance of the encoding process, with a focus on the latest streaming methods and codecs. Then, it examines the role of cloud systems in multimedia environments and provides details on the cloud infrastructure for media scenarios. After doing a systematic literature review, we have been able to find 49 valid papers that meet the requirements specified in the research questions. Each paper has been analyzed and classified according to several criteria, besides to inspect their relevance. To conclude this review, we have identified and elaborated on several challenges and open research issues associated with the development of video codecs optimized for diverse factors within both cloud and edge architectures. Additionally, we have discussed emerging challenges in designing new cloud/edge architectures aimed at more efficient delivery of media traffic. This involves investigating ways to improve the overall performance, reliability, and resource utilization of architectures that support the transmission of multimedia content over both cloud and edge computing environments ensuring a good quality of experience for the final user.
Future changes in intense tropical cyclone hazards in the Pearl River Delta region: an air-wave-ocean coupled model study
Authors: Li Zhenning , Fung Jimmy C. H. , Wong Mau Fung , Lin Shangfei , Cai Fenying , Lai Wenfeng , Lau Alexis K. H.
Published: March 2024

The Pearl River Delta (PRD) region is highly vulnerable to tropical cyclone (TC)-caused coastal hazards due to its long and meandering shoreline and well-developed economy. With global warming expected to continue or worsen in the rest of the twenty-first century, this study examines the TC impact on the PRD coastal regions by reproducing three intense landfalling TCs, namely Vicente (2012), Hato (2017), Mangkhut (2018), using a sophisticated air-wave-ocean coupled model of high spatial resolution (1-km atmosphere and 500-m wave and ocean). The simulations are conducted using present-day reanalysis data and the same TCs occurring in a pseudo-global warming scenario projected for the 2090s. Results indicate that the coupled model accurately reproduces the air-wave-ocean status during the TC episodes. The 2090s thermodynamic status effectively increases the intensity of intense TCs, leading to more severe coastal hazards including gale, rainstorm, and storm surges and waves. On average, the maximum surface wind speed within 50–200 km to the right of the TC center can increase by 4.3 m/s (+22%). The 99th and the 99.9th percentile of accumulated rainfall will increase from 405 to 475 mm (+17.3%), and from 619 to 735 mm (+18.6%), respectively. The maximum significant wave height at the ocean is lifted by an average of 57 cm (+13.8%), and the coastline typically faces a 40–80 cm increase. The maximum storm surges are lifted by 30–80 cm over the open sea but aggravate much higher along the coastline, especially for narrowing estuaries. For Typhoon Vicente (2012), there is more than a 200 cm wave height increase observed both at open sea and along the coastline. In the 2090s context, a combination of mean sea level rise, storm surge, and wave height can reach more than 300 cm increase in total water level at certain hot-spot coastlines, without considering the superposition of spring tides.
Alya toward exascale: algorithmic scalability using PSCToolkit
Authors: Owen Herbert , Lehmkuhl Oriol , D’Ambra Pasqua , Durastante Fabio , Filippone Salvatore
Published: March 2024

In this paper, we describe an upgrade of the Alya code with up-to-date parallel linear solvers capable of achieving reliability, efficiency and scalability in the computation of the pressure field at each time step of the numerical procedure for solving a Large Eddy Simulation formulation of the incompressible Navier–Stokes equations. We developed a software module in the Alya’s kernel to interface the libraries included in the current version of , a framework for the iterative solution of sparse linear systems, on parallel distributed-memory computers, by Krylov methods coupled to Algebraic MultiGrid preconditioners. The Toolkit has undergone various extensions within the EoCoE-II project with the primary goal of facing the exascale challenge. Results on a realistic benchmark for airflow simulations in wind farm applications show that the solvers significantly outperform the original versions of the Conjugate Gradient method available in the Alya’s kernel in terms of scalability and parallel efficiency and represent a very promising software layer to move the Alya code toward exascale.
About the Alkemade Theorem and the Limits of its Applicability for the Construction of Ternary Liquidus Surfaces
Authors: Stein F. , He C.
Published: March 2024

The Alkemade theorem goes back to a very fundamental paper on the graphical description of thermodynamic equilibrium problems from 1893 (van Rijn van Alkemade in Z Phys Chem 11: 289-327, 1893). It is one of the most helpful implements for the construction of the liquidus surface of ternary phase diagrams. In its original form, it allows to find the direction of falling or increasing temperature along the monovariant reaction lines forming the boundaries of the primary crystallization fields. The theorem is valid for systems with any number of phases; however, its geometrical construction rule is only defined for the case of stoichiometric phases and it is not clear how to apply the theorem in the case of phases with extended homogeneity ranges. Some examples from a ternary, transition-metal-based system containing phases with large homogeneity ranges are presented, and the usefulness and limits of applicability of the theorem are discussed.
Agile-as-a-tool and agile-as-a-culture: a comprehensive review of agile approaches adopting contingency and configuration theories
Authors: Magistretti Stefano , Trabucchi Daniel
Published: March 2024

Today’s world requires new approaches to innovation that leverage continuous testing and pivoting. Speed and the ability to respond to exogenous shocks are becoming increasingly important in both theory and practice. Following the introduction of the Agile Manifesto in 2001, a wide range of industries have adopted agile approaches, which differ from other ways of managing innovation projects by promoting flexibility and the rapid development of new solutions. Despite the proliferation of agile approaches across industries, the literature lacks a systematic understanding of their underlying elements. Therefore, we conduct a systematic literature review using a text mining technique to longitudinally explore the evolutionary dynamics of the field. Analyzing the results through the dichotomous lens of contingency and configuration theories, we show that the agile literature can be systematized into two perspectives: agile-as-a-tool in the contingency perspective, and agile-as-a-culture in the configuration perspective. Our review reveals underexplored intersections in the field of innovation and provides interesting insights into these two perspectives. We also propose a research agenda to shed light on these emerging perspectives in the agile innovation and management literature.
Direct Minimization of the Canham–Helfrich Energy on Generalized Gauss Graphs
Authors: Kubin Anna , Lussardi Luca , Morandotti Marco
Published: March 2024

The existence of minimizers of the Canham–Helfrich functional in the setting of generalized Gauss graphs is proved. As a first step, the Canham–Helfrich functional, usually defined on regular surfaces, is extended to generalized Gauss graphs, then lower semicontinuity and compactness are proved under a suitable condition on the bending constants ensuring coerciveness; the minimization follows by the direct methods of the Calculus of Variations. Remarks on the regularity of minimizers and on the behavior of the functional in case there is lack of coerciveness are presented.
Marsupials (Herpetotheriids) from the late Palaeogene of south-east Serbia
Authors: Wessels Wilma , van de Weerd Andrew A. , Marković Zoran
Published: March 2024

Three marsupial species are present in Palaeogene assemblages from south-eastern Serbia, Amphiperatherium minutum (Aymard, 1846), A. exile (Gervais, 1848–1852) and a species of Peratherium Aymard, 1850. These species are common in the late Eocene and early Oligocene of Western and Central Europe and their presence in South-Eastern Europe indicate that by the end of the Eocene, the eastwards dispersal of these marsupial species was already a fact. The presence of the same marsupial species in Serbia and in Western Europe is surprising, as the difference in composition between the Serbian and Western European rodent faunas indicates a limited faunal exchange between these areas in the late Eocene and early Oligocene. In marsupials, the stylar shelf of the upper molars shows a large morphological variation. A lesser-known variation is the presence of a transverse crista in the stylar shelf. These occur in various marsupial species, but so far were not known to be present in Amphiperatherium minutum. In our opinion, the large morphological variation of the stylar shelf is thus better not used to define a new species.
Large-scale agricultural investments and local food security – Evidence from a mixed-method case study in Benin
Authors: Muder Anika , Luckmann Jonas , Schmid Julia C.
Published: March 2024

Large-scale agricultural investments (LSAIs) and their impacts on local communities in host countries have been controversially discussed in recent years. As scholars increasingly call for more structured and comprehensive analyses, we develop a mixed-method approach using an expanded version of the “Right to Food” (RtF) framework to systematically investigate the local food security impacts of a recently established tomato-producing LSAI in Central Benin, West Africa. We find that the LSAI keeps natural resources as accessible as possible for the local community and provides employment opportunities, leading to higher dietary diversity of employees and multiplier effects in the local economy. At the same time, we find inequalities regarding the compensation of former land users as well as high job insecurity for temporary laborers who face high transportation costs to reach the LSAI. We argue that fair and inclusive compensation, improved access to markets and machinery, access to natural resources for often overlooked groups (pastoralists, hunters, fishermen) and social infrastructure are crucial factors in promoting positive outcomes of LSAIs on communities and that strong local institutions play a key role for achieving this. We conclude that the specific characteristics of our case (relatively small size, labor-intensive crop, focus on regional markets) provide favorable conditions for positive impacts on local food security. We encourage further, structured mixed-method studies, ideally including longitudinal and comparative research designs, to investigate the multidimensional effects related to the establishment of LSAIs. The extended RtF framework can thereby serve as a structural lens to systematically analyze the findings.
Transcriptome and single-cell transcriptomics reveal prognostic value and potential mechanism of anoikis in skin cutaneous melanoma
Authors: Liu Xing , Zhang Hong-Yan , Deng Hong-Ao
Published: March 2024

Background

Skin cutaneous melanoma (SKCM) is a highly lethal cancer, ranking among the top four deadliest cancers. This underscores the urgent need for novel biomarkers for SKCM diagnosis and prognosis. Anoikis plays a vital role in cancer growth and metastasis, and this study aims to investigate its prognostic value and mechanism of action in SKCM.

Methods

Utilizing consensus clustering, the SKCM samples were categorized into two distinct clusters A and B based on anoikis-related genes (ANRGs), with the B group exhibiting lower disease-specific survival (DSS). Gene set enrichment between distinct clusters was examined using Gene Set Variation Analysis (GSVA) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.

Results

We created a predictive model based on three anoikis-related differently expressed genes (DEGs), specifically, FASLG, IGF1, and PIK3R2. Moreover, the mechanism of these prognostic genes within the model was investigated at the cellular level using the single-cell sequencing dataset GSE115978. This analysis revealed that the FASLG gene was highly expressed on cluster 1 of Exhausted CD8( +) T (Tex) cells.

Conclusions

In conclusion, we have established a novel classification system for SKCM based on anoikis, which carries substantial clinical implications for SKCM patients. Notably, the elevated expression of the FASLG gene on cluster 1 of Tex cells could significantly impact SKCM prognosis through anoikis, thus offering a promising target for the development of immunotherapy for SKCM.