bluuebunny/crossref_metadata_2025 huggingface dataset:
EcoDataCube.eu: Analysis-Ready Open Environmental Data Cube for Europe
Authors: Witjes Martijn , Parente Leandro Leal , Krizan Josip , Antonic Luka , Hengl Tomislav
Published: November 2022

The paper describes production steps and accuracy assessment of an analysis-ready open
environmental data cube (2000--2021+) for continental Europe; at working resolutions
from 10~m to 30~m and with quarterly to annual estimates. The data cube is based on
processing and harmonizing earth observation (EO) images: Landsat GLAD ARD (2000-
-2020+), Sentinel-2 images (2017--2021+) and Digital Elevation data. These datasets were
created with accessibility, user-friendliness, interoperability and synthesis in mind. This
has required systematic spatiotemporal harmonization, efficient compression, and
imputation of missing values. To ensure a missing value percentage below 1%, the EO
data was first aggregated into 4 quarterly periods approximating the 4 seasons common in
Europe (winter, spring, summer and autumn), and then split into three percentiles (25th,
50th and 75th). Remaining missing data in the Landsat time-series was imputed with a
temporal moving window median (TMWM) approach. The accuracy assessment shows
TMWM gap-ûlling achieves higher performance in Southern Europe, and lower performance
in mountainous regions such as the Scandinavian Mountains, the Alps, and the Pyrenees.
The intended uses of the EcoDataCube platform include vegetation, soil, land cover and
land use mapping projects, environmental monitoring and automated generation of data
for statistical oûces including Eurostat. Combining all four datasets produced in this work
(DTM, Landsat 30m, Sentinel-2 30m and Sentinel-2 10m) yields the highest land cover
classification accuracy, with different datasets improving the results for different land
cover classes. The Environmental data cube for Europe is available under CC-BY license as
Cloud-Optimized GeoTIFFs (ca. 12TB in size) through STAC and the EcoDataCube data
portal.
Influence of Internal and External Imaging Plane Inclination on Assessment of Trochlear Depth, Sulcus Angle, And Facet Asymmetry in the Setting of Trochlear Dysplasia: A Cadaveric Study
Authors: Vranken Kristel , Doring Seema , Buls Nico , Vanlauwe Johan , Germonpré Sofie , Provyn Steven , De Smet Aron , De Maeseneer Michel
Published: November 2022

Purpose
(1) to assess the influence of internal or external imaging plane inclination on measurement of sulcus angle, trochlear depth, and facet asymmetry on transverse cross-sectional images. (2) to assess the effect of measurement level (height) on these respective parameters.
Materials and methods
Twenty dry femurs (9 left, 11 right) were imaged with CT. A 3D dataset was obtained from which axial images were reconstructed in the ideal plane without inclination as well as with 8° of medial and lateral inclination. Sulcus angle, trochlear depth, and facet asymmetry were measured on the 3 image sets. In addition, the measurements were performed at 5 mm and 10 mm from the superior margin of the medial trochlear facet. Statistical analysis consisted of Wilcoxon test and calculation of measurement variation.
Results
There were no statistically significant differences between the indicated measurements on the reference set compared to medial or lateral inclination. All measurements were significantly different depending on measurement height.
Conclusion
Medial or lateral inclination in the transverse imaging plane of 8 ° does not influence the values of typical parameters used for assessment of trochlear dysplasia. The measurement height has a significant influence, and a consensus should be found as to which is the optimal measurement height.
UnidecNMR: Automatic peak detection for NMR spectra in 1-4 dimensions
Authors: Buchanan Charles , Karunanithy Gogulan , Tkachenko Olga , Barber Michael , Marty Michael , Baldwin Andrew
Published: November 2022

To extract information from NMR experiments, users need to identify the number of resonances in the spectrum,together with characteristic features such as chemical shiftsand intensities. In many applications, particularly those involving biomolecules, this procedure is typicallya manual and laborious process. While manyalgorithms are available to tackle this problem, theirperformance tends to be inferior to that of an experienced user.Here,weintroduce UnidecNMR, which identifies resonances in NMR spectra using deconvolution. We demonstrate itsfavourable performance on 1 and 2D simulatedspectra,strongly overlapped 1D spectra of oligosaccharides and2D HSQC,3D HNCO, 3DHNCA and 3/4D methyl-methyl NOE experimental spectra from a range of proteins. UnidecNMR outperforms a number of freely available algorithms and provides results that are either of similar quality to those generated manually, or in the case of NOE data, superior. We demonstrate that introducing additionalrestraints, such as a 2D peak listwhen analysing 3 and 4D data and incorporating reflection symmetryin NOE analysisfurther improves the results. UnidecNMR outputs a back-calculated spectrum and a peak list, both of which can be easily examined using the supplied GUI. The software allows interactive processing of raw data using nmrPipe. UnidecNMR is free for academic use and can function as either part of an automatic pipeline or provide an excellent ‘first guess’ of peak locations as part of a semi-automatic analysis.
The Presidential period in the United States of America and stock returns, evidence from Iran
Authors: Dadaneh Foad Zamani , Khezre Mehran , Haghighat Hamid
Published: November 2022

The most important event in the world is the presidential election in the United States of America, to which the stock markets of many countries react. This reaction may differ according to the presidential period in which one of the candidates is selected. Accordingly, our research aims to investigate the effect of two presidential periods with two different parties on the stock returns of companies listed on the Tehran Stock Exchange. Hence, using the analysis of 650 firm-year observations for the first period and 1095 firm-year observations for the second period, for two different presidential periods, respectively, the presidency of Barack Obama (Democratic Party) and Donald Trump (Republican Party), we find that the elections and the presidential period of both parties have a negative, significant effect on the annual cumulative stock returns of companies. Results show that investors react to events such as elections, even in emerging markets like Iran.
A novel weevil-transmitted tymovirus found in mixed infection on hollyhock
Authors: Mahillon Mathieu , Brodard Justine , Kellenberger Isabelle , Blouin Arnaud , Schumpp Olivier
Published: November 2022

Leaves of hollyhock (Alcea rosea) exhibiting vein chlorosis and yellow mosaic symptoms were collected at public sites in Lausanne and Nyon, two cities of western Switzerland. Classical diagnostic methods untangled in samples from both sites the mixed infections of a novel isometric virus, tentatively named “Alcea yellow mosaic virus” (AYMV) with the carlavirus Gaillardia latent virus. A new potyvirus was also identified in samples from Nyon. A combination of Illumina, Nanopore and Sanger sequencing was necessary to assemble the full-length genome of AYMV, revealing an exceptionally high cytidine content and other features typically associated with members of the genus Tymovirus. The host range of AYMV was found to be restricted to mallows, including ornamentals as well as economically important plants. Phylogenetic analyses further showed that AYMV belongs to a Tymovirus subclade that also gathers the other mallow-infecting members. The virus was readily transmitted by sap inoculation, and the weevil species Aspidapion radiolus was evidenced as a vector. Transmission assays using another weevil or other insect species did not succeed, and seed transmission was not observed.
'Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity’
Authors: Shukla Rahul , Ahuja Richa , Beesetti Hemalatha , Garg Amit , Aggrawal Charu , Chaturvedi Shivam , Nayyar Kaushal , Arora Upasana , Lal Altaf A. , Khanna Navin
Published: November 2022

Dengue Virus (DENV) infection has increased worldwide, with over 400 million infections annually, and has become a serious public health concern. Several drug candidates, new and repurposed, have failed to meet the primary efficacy endpoints. We have recently shown that Aqueous Extract of the stem of Cocculus hirsutus (AQCH) was effective in vitro and in vivo against DENV and was safe in humans. We now report that an active ingredient of AQCH, Sinococuline, protects against the antibody-mediated secondary-DENV infection in the AG129 mouse model. DENV infection markers were assessed, viz. serum viremia and vital organs pathologies- viral load, proinflammatory cytokines and intestinal vascular leakage. The treatment with Sinococuline at 2.0 mg/kg/dose, twice a day (BID), was the most effective in protecting the severely DENV-infected AG129 mice. Also, this dose effectively reduced serum viremia and tissue-viral load and inhibited the elevated expression levels of proinflammatory cytokines (TNF-α & IL-6) in several vital organs. Based on these findings, it could be explored further for pre-clinical and clinical developments for the treatment of dengue.
The Prevalence and Risk Factors of Autistic Experiences of Interpersonal Violence: A Systematic Review and Meta-Analysis
Authors: Cooke Kassandrah , Ridgway Kathryn , Westrupp Elizabeth , Hedley Darren , Hooley Merrilyn , Stokes Mark A.
Published: November 2022

Background:Interpersonal violence is a widespread yet understudied issue in autism spectrum disorder (henceforth, ‘autism’). While themultiple minority stressmodel suggests gender marginalised groups (e.g., females, transgender, non-binary) are at greater risk, research investigating this model among autistic populations is limited. The current review and meta-analysis examined the prevalence and risk factors associated with interpersonal violence among autistic individuals of varying gender identities.Methods:A systematic database search identified 42 studies examining: (1) a combination of physical, sexual, or psychological violence; (2) physical violence; (3) sexual violence; (4) psychological violence; (5) traditional bullying; (6) cyberbullying; and (7) homicide among autistic people across all age groups and support needs levels, compared by gender. A random-effects meta-analysis with pooled data from 13 eligible studies was undertaken, comprising 4,498 participants (malesn= 3,472; femalesn= 1,026) aged between 2 to 56 years.Results:Analyses indicated overall violence prevalence is increased among females compared to males,d= 0.44,p< .001; 95% CI [0.24, 0.65], across all ages and support needs levels. The largest effect was for childhood maltreatment and negative social events during adulthood,d= 1.07,p< .05, [0.20, 1.93]. Narrative synthesis of 37 studies indicated autistic people were significantly more likely to be victimised by carers and peers compared to non-autistic people. Key risk factors included belonging to a gender or racial minority, having co-occurring mental health issues, and coming from a low-income household.Limitations:The generalisability of findings was limited by the shortage of literature about autistic experiences of violence not involving bullying, participants with high needs, and participants outside of the binary gender. This may also contribute to the high level of heterogeneity (I2= 87%) found.Conclusions:The results of this review and meta-analysis indicate that interpersonal violence is a pressing issue among autistic people, who appear to face concerningly high rates of victimisation and poly-victimisation across the life course, particularly among multiply marginalised people (i.e., gender, race, mental health, economic). This underscores the importance of exploring violence from an intersectional perspective, across individual and societal contexts, providing support for multiple minority theory.
Exploring the expression and the prognosis of mismatch repair protein and PD-L1 in colorectal cancer
Authors: Zhang Yaping , Han Lu , Zhang Qun , Liu Zhihao , Niu Haiqing , Li Li , Hu Jing , Shi Xiao , Ding Zhou , Qian Xiaoping
Published: November 2022

Background Colorectal cancer (CRC) is one of the most common malignancies of the gastrointestinal tract, it is very important to find biomarkers that can accurately predict the therapeutic efficacy to accurately grasp the development of the disease, this study aims to investigate the expression and clinical significance of mismatch repair (MMR) protein and programmed cell death 1 ligand 1 (PD-L1) in samples from surgically resected colorectal cancer (CRC) patients. Methods A total of 272 surgically resected CRC patients attending at Drum Tower Hospital of Nanjing University School of Medicine from January 2018 to May 2022 were retrospectively included in the study. Collect surgical excision samples from all patients and record in detail the general data, clinicopathological data, and imaging data of all subjects. Immunohistochemistry (IHC) and Western Blot were used to detect the expression of MSH2, MSH6, MLH1, and PMS2 proteins in the tumor tissue and normal tissue adjacent to the cancer of the resected samples, respectively. X2 test was used to investigate the correlation between the expression of MMR protein and PD-L1 in CRC tumor tissues and the clinicopathological characteristics, then further analyzed the correlation between the deletion of four MMR proteins in CRC tumor tissues, and finally investigated the relationship between the expression of MMR protein and PD-L1 and the prognosis of CRC patients by survival curve and Log Rank test. Results 1. MMR protein expression deletion was correlated with tumor location, differentiation degree, and TNM stage (P < 0.05); while PD-L1 expression was only correlated with TNM stage (P < 0.05). 2. Correlation analysis of MMR protein isoform expression deletion found that PMS2 expression deletion was significantly correlated with MLH1 expression deletion, similarly, MSH2 expression deletion was significantly correlated with MSH6 expression deletion was significantly correlated with MSH6 expression deletion (P < 0.05), in addition, PMS2 expression deletion was also correlated with PD-L1 expression (P < 0.05). 3. The survival time was shorter in dMMR patients compared with pMMR patients. Conclusion Deletion of MMR protein expression and expression of PD-L1 are closely related to clinicopathological characteristics and prognosis of CRC patients, maybe MMR and PD-L1can be potential biomarkers.
Allometry of antipredatory jumping on water by water striders
Authors: Kim Woojoo , Amauger Juliette , Ha Jungmoon , Pham Thai , Tran Anh Duc , Lee Jae Hong , Park Jinseok , Jablonski Piotr , Kim Ho-Young , Lee Sang-im
Published: November 2022

Current theory for surface tension-dominant jumps on water, created for small and medium size water strider species and used in bio-inspired engineering, predicts that jumping individuals are able to match their downward leg movement speed to their size and morphology such that they maximize the takeoff speed and minimize the takeoff delay without breaking the water surface. Here, we use empirical observations and theoretical modeling to show that large species (heavier than ~80 mg) do not conform to this prediction but switch to using surface-breaking rather than surface tension-dominant jumps in order to achieve jumping performance that appears sufficient for evading attacks from underwater predators. This suggests that natural selection for avoiding predators may break the theoretical scaling relationship between prey size and its jumping performance within one physical mechanism leading to an evolutionary shift to another mechanism of jumping on water.
Effects of phosphorus limitation on the bioavailability of DOM released by marine heterotrophic prokaryotes
Authors: Bouchachi Nawal , Obernosterer Ingrid , Bastos Cécile Carpaneto , Li Franck , Scenna Lorenzo , Marie Barbara , Crispi Olivier , Catala Philippe , Ortega-Retuerta Eva
Published: November 2022

Heterotrophic prokaryotes (HP) contribute largely to dissolved organic matter (DOM) processing in the ocean, but they also release diverse organic substances. The bioavailability of DOM released by HP under varying environmental conditions are not fully elucidated. In this study, we investigated the effect of P-limitation on the bioavailability of DOM released by a single bacterial strain and 2 natural HP communities. These HP were grown under P-replete and P-limited conditions, and their DOM (HP-DOM) was used as a substrate for natural prokaryotic communities from a coastal site in the Northwestern Mediterranean Sea. We followed changes in prokaryotic growth, enzymatic activity, diversity and community composition together with the consumption of HP-DOM fluorescence (FDOM). HP-DOM produced under P-replete and P-limited conditions promoted both significant and similar prokaryotic growth. The humic-like fluorescence, commonly considered recalcitrant, was consumed during the incubations when this peak was initially dominating the FDOM pool, and this consumption coincided with higher alkaline phosphatase activity. HP-DOM supported growth of diverse prokaryotic communities and P-driven differences in HP-DOM quality selected for different indicator taxa in the degrading communities. Taken together, our findings emphasize that HP-DOM lability is dependent on both the DOM quality, shaped by P availability, and the composition of the consumers community.
Systematic Case Management for Disabled Workers Due to Occupational Accident Throughout Return to Work Program in Indonesia: a Qualitative Study
Authors: Kurnianto Arie , Khatatbeh Haitham , Prémusz Viktória , Zsolt Nemeskéri , Ágoston István
Published: November 2022

Background
Few research and a dearth of studies show the effectiveness of case management for people with disabilities throughout the Return To Work (RTW) program in underdeveloped countries, which is meant to help disabled workers to regain their dignity through medical, vocational, and psychological rehabilitation.
Methods
Design of qualitative research primarily based on secondary data retrieved from BPJS Ketenagakerjaan and enhanced through in-depth interviews with case managers involved in the RTW program. Data analysis from in-depth interviews was analyzed using QDA Miner Lite, and descriptive study was visualized using Python with ArcGIS integration.
Results
The most from this analysis is that the RTW program of BPJS Ketenagakerjaan has already implemented ILO's primary recommendation, which generates two key themes: vital internal factors that are integral to the RTW framework and external key factor that is stakeholder groups affect RTW practice. The key themes produce six main pieces to discuss further: personal skill, personal literacy, providers, guidelines, authorities, and stakeholder support.
Conclusion
Return to Work Program benefits companies, and the implementation of a career development service or a partnership with non-governmental organizations guarantees that disabled employees who cannot return to work with their former employers are still in the global economy.
Structured Physical Exercise for Bipolar Depression: An open-label, proof-of concept study
Authors: Lafer Beny , Duarte Cicera Claudinea , Greve Julia Maria D’Andrea , Silva Paulo Roberto Santos , Almeida Karla Mathias , Belizário Gabriel Okawa , Neves Lucas Melo
Published: November 2022

Background
Physical exercise is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder. Considering the similar symptomatology of the depressive phase in patients with bipolar disorder (BD) and unipolar depressive disorder, it is reasonable to suggest that physical exercise may also be beneficial for bipolar depression. However, there is an absence of studies evaluating the antidepressant effect of a structured physical exercise intervention in BD.
Methods
This is an open-label, single-arm study trial. Fifteen patients with a diagnosis of BD Type I or Type II, presenting a depressive episode were included in the study. After physical and functional evaluation, patients participated in supervised training sessions with aerobics followed by strength exercises, three times per week, for 12 weeks (36 training sessions). Depressive and manic symptoms were assessed at baseline and 2, 4, 8, and 12 weeks. Additionally, quality of Life and functioning were assessed at baseline and 4, 8, and 12 weeks).
Results
The mean (± SD) Montgomery Asberg Depression Rating Scale (MADRS) score at baseline was 23.6 ± 8.3 points and after 12 weeks of physical exercise the mean score was 10.2 ± 4.8 points. Nine patients (82%) presented an antidepressant response defined as a reduction of more than 50% of depressive symptoms at week 12 with five of those patients (45%) presenting criteria for full remission. A large and significant Cohen’s D Effect Size (pre-post) was verified for MADRS reduction [1.98 (95% Confidence interval =0.88 to 3.08)]. We did not detect a significant change in manic symptoms, functioning, and quality of life during the 12-week follow-up.
Conclusions
This study, using rigorous criteria and a structured intervention, provides valid pilot data, showing the feasibility of a structured physical exercise intervention for the treatment of depressive symptoms in BD, and suggesting a potential adjunctive antidepressant effect. This should be further verified by randomized controlled studies.
Novel V-shape kiss flap harvest technique for the forearm free flap in soft tissue reconstruction.
Authors: Zhao Wenquan , Zhu Wenyuan , Yu Dan , Zhu Huiyong , Liu Jianhua , Ni Youkang
Published: November 2022

Introduction: Radial forearm flap (RFF) is widely used in oral reconstruction. However, the donor-site defect remains the main limit. In this paper, V-shape kiss RFF (VRFF) is described as a novel technique to improve aesthetics and function of it. A retrospective study was conducted to introduce VRFF and evaluate its effect and safety.
Methods: A total of 21 patients who underwent VRFF for oral reconstruction, and 23 patients who underwent conventional RFF from February 2016 to April 2018 were included for this study. Direct comparisons were made on patient’s subjective evaluation of post-operative hand function and degree of scarring) and objective donor-site function assessment including range of wrist movements and grip strength before and after surgery between the 2 groups.
Results: No skin grafts were used in the VRFF group, and 20 of 21 patients achieved primary healing at donor site. While, all patients from the RFF group had skin grafts. And 18 of 23 patients achieved primary healing. The postoperative scar score of donor site in the VRFF group was significantly higher than that in the RFF group(3.4vs2.8, P=0.035). There was no significant differences in other subjective evaluation and donor-site morbidity and hand function assessment.
Conclusion: VRFF is able to provide a new and simple method to close donor-site defect and realize a better healing in donor site.
Selenium-enriched Bacillus subtilis Improves Growth Performance, Antioxidant Capacity, Immune Status and Gut Health of Broiler Chickens
Authors: Qiu Huiling , Gao Shansong , Hou Lele , Li Anping , Zhu Lian-qin , Dong Jihong , Chen Fu
Published: November 2022

This study aimed to investigate the effects of selenium (Se) - enriched Bacillus subtilis (Se-BS) on growth performance, antioxidant capacity, immune status and gut health in broilers. A total of 240 day-old Arbor Acres broilers were randomly allotted to four treatments of a basal diet supplemented with no Se, sodium selenite (SS), B. subtilis (BS), and Se-BS and raised for 42 days. The results showed that Se-BS supplementation significantly increased body weight (BW), average daily gain, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and peroxidase (POD), total antioxidant capacity (T-AOC), interleukin (IL) -2, IL-4 and immunoglobulin (Ig) G contents in plasma, the index and wall thickness of duodenum, the villus height and crypt depth of jejunum, GPx-1 and thioredoxin reductase 1 (TR-1) mRNA levels in liver and intestine (P < 0.05), and decreased feed conversion ratio (FCR) and malondialdehyde (MDA) content in plasma (P < 0.05). Compared with the SS and BS groups, Se-BS supplementation significantly increased BW, the activities of GPx, CAT and POD, and the contents of IL-2, IL-4 and IgG in plasma, the index and wall thickness of duodenum, crypt depth and sIgA content of jejunum, and GPx-1 mRNA level in liver and intestine (P < 0.05), and decreased FCR and MDA content in plasma (P < 0.05). This study provides scientifc basis for further understanding Se-BS as a more effective measure to improve growth performance and healthy of broilers.
Adsorption and desorption of the flavonoids on activated carbon impregnated with different metal ions
Authors: Lu Li , Cao Shuang , Li Zhexuan , Huang Jingdan , Jiang Yukai , Deng Changyong , Liu Ziwei
Published: November 2022

In this paper, four metal ions Mg2+, Al3+, Fe3+ and Zn2+ were loaded on the surface of activated carbon by impregnation method to prepare modified activated carbon. High-temperature calcination was used to activate the activated carbon loaded with the metal ions. Scanning electron microscopy, specific surface area and pore size analyzer, X-ray diffraction, and Fourier infrared spectroscopy were used to evaluate the structure and morphology of the modified activated carbon. The findings show that the modified activated carbon charactered in a large of microporous structures and specific surface area, both of which significantly improve the activated carbon absorbability. The study also involves the adsorption and desorption kinetics of the prepared activated carbon for three flavonoids. It was found that the prepared activated carbon had high adsorption efficiency for all three flavonoids, but the desorption efficiency of three flavonoids varied a lot. Naringenin is easier to be desorbed at alkaline condition, the elution percentage is 50% higher than that of the other two flavonoids. This difference provides a basis for the application of this type of activated carbon in the selective enrichment and separation of flavonoids.
Robotic colorectal cancer surgery in the elderly – a monocentric analysis of short- term postoperative outcomes in patients ≥ 75 years versus <75 years
Authors: Holzgang Melanie , Hamed Mazin , Chen Yining , Famurewa Jolaa , Ward Wanda , Dowsett Dolly , Shaikh Irshad , El-Hadi Ahmed
Published: November 2022

Introduction
Colorectal cancer is increasingly prevalent in the elderly. We aimed to investigate the short-term postoperative outcomes in robotic colorectal cancer surgery in an elderly (≥ 75 years) versus a non-elderly (< 75 years) patient group.
Materials and Methods
228 patients (61 patients > 75yrs vs. 167 < 75yrs) with confirmed colorectal cancer, operated between 10/17 and 05/22 with the Da Vinci X system, were identified. Short-term postoperative outcomes were compared using the Chi-squared/Fisher’s exact or Wilcoxon test. P < 0.05 was considered statistically significant.
Results
No statistical differences were observed in any of the outcomes looked at between our two patient groups, nor overall, nor analyzing left- or right-sided resections separately. Looking at left resections, operative time was shorter in the elderly group (314.66 min vs. 327.76 min, p = 0.347) whereas length of stay was over a day longer (7.72 vs. 6.08, p = 0.054), however, the differences observed did not reach statistical significance. Anastomotic leak, re-admission and re-operation rates in left resections were all higher in the non-elderly group (11% vs. 0%, p = 0.075; 8.1% vs. 3.4%, p = 0.694; 3.7% vs. 0%, p = 0.588), however, all not statistically significant. Looking at right resections, operative time was non significantly shorter in the elderly group (239.13 min vs. 259.81, p = 0.363), whereas length of stay was nearly identical (5.63 days vs. 5.52 days, p = 0.867).
Conclusion
Our Study results suggest that robotic colorectal cancer surgery is safe and feasible in elderly patients. Elderly patients demonstrated comparable outcomes to the non-elderly group in terms of operative times and short-term postoperative outcomes.
Associations between adverse childhood experiences and depressive and anxiety symptoms in adolescents and young adults
Authors: Moriya Renato Mikio , Urbano Mariana Ragassi , Vargas Heber Odebrecht , Machado Regina Celia Bueno , Araújo Cássia , Reiche Edna Maria Vissoci , Nunes Sandra Odebrecht Vargas
Published: November 2022

Adverse childhood experiences (ACEs) have been associated with chronic health problems in adolescents and young adults. The aim of this study was to investigate in adolescents and young adults how lower quality of life, elevated perceived stress and ACEs could influence depression and anxiety symptoms, practice of physical activity, loss of control while eating, tobacco use, and obesity/overweight. Participants were assessed by questionnaire and scales, including the 17-item Hamilton Depressive Rating Scale (HDRS17), Hamilton Anxiety Rating Scale (HAM-A), Adverse Childhood Experiences Questionnaire, the World Health Organization quality of life (WHOQOL-BREF) total score, the global physical activity questionnaire, the Perceived Stress Scale, the loss of control overeating scale and anthropometric measures. The participants who experienced ≥ 4 types of ACEs (n = 10) had more major depressive disorder (p < 0.01), higher scores on the Perceived Stress Scale (p = 0.03), lower quality of life (p < 0.01) and domains of physical and psychological health (p < 0.03) than those with < 4 types of ACEs (n = 52). Higher scores on the Perceived Stress Scale and lower scores on the WHOQOL-BREF were associated to higher prevalence of more severe depressive symptoms [Prevalence Ratio (PR) = 4.02, 95% confidence interval (CI): 1.46–16.88, p = 0.03], more severe anxiety symptoms (PR = 2.11, 95% CI: 1.30–3.41, p < 0.01) and ≥4 ACEs (PR = 1.85, 95% CI: 1.19–2.88, p < 0.01). Implications of these findings for clinical practice were pay more attention to health care of adolescent and young adults who survived of higher childhood maltreatments and had more severe depressive and anxiety symptoms to therapeutic target.
The association between social isolation and loneliness with COVID-19 vaccine uptake
Authors: Ukai Tomohiko , Tabuchi Takahiro
Published: November 2022

As coronavirus disease 2019 (COVID-19) vaccine uptake has plateaued at an unsatisfactory level, we must detect groups who are potential vaccine recipients. We examined social isolation and loneliness, increasingly recognised but neglected social determinants of health, as associated with being unvaccinated. Using a representative sample of the Japanese general population from Internet surveys (JACSIS 2021 and JASTIS 2022), social isolation was assessed using the Lubbern Social Network Scale and loneliness was assessed using the UCLA Loneliness Scale version 3. We used a multivariable logistic regression model to calculate the odds ratio (OR) of being unvaccinated in 2022 in socially isolated or lonely people after adjusting for demographics. In addition, we asked unvaccinated participants why they were not vaccinated. Our results show that people who were socially isolated were significantly less likely to receive information from people who had been vaccinated (11% vs. 15%), and less likely to have a negative impression of vaccination (27% vs. 19%) compared with people who were not socially isolated. Socially isolated people tended not to have had a COVID-19 vaccination even though they had no negative impression regarding the vaccine. Socially isolated people are important targets to reach to increase the number of vaccinated people.
Effect of Chromium Propionate Supplementation on Biochemical and Hormonal Parameters of Sheep During Gestation and Lactation
Authors: Moreira Flávia Mallaco , Almeida Daniela Lázara , Coimbra Thais Bianconi , Nascimento Isabella Tomaz , Negrão João Alberto , Gallo Sarita Bonagurio
Published: November 2022

Chromium (Cr) is a trace element that places a role in the insulin sensitivity mechanism and its supplementation can alter energy metabolism and related blood parameters. This study aimed to evaluate the effects of Cr propionate doses supplementation in ewes, during late pregnancy and lactation, on biochemical and hormonal parameters. Thirty-one ewes, Santa Inês and Dorper crossbreed, single gestation, 63 ± 10 kg of body weight, age 3 ± 2 years, were randomly assigned into 4 treatments: without supplementation (CR0) and daily supplementation of 0.5 mg (CR0.5), 1.0 mg (CR1.0) and 1.5 mg (CR1.5) of chromium per animal. Daily supplementation occurred from the 100th day of gestation to the 60th day after lambing, totalizing 110 days. Blood samples were collected five times during trial. Data were analyzed using SAS program, PROC MIXED and means compared by Tukey test with P ≤ 5% for significance and 5% < P ≤ 10% for tendency. During gestation, CR0.5 tended to decrease blood non-esterified fatty-acids levels (P < 0.1). During lactation, CR0.5 tended to present lower ß-hydroxybutyrate level compared to CR1.0 (P < 0.1) and had lower insulin:glucose ratio compared to CR0 (P < 0.05). Serum phosphorus levels increased with higher doses of Cr (P < 0.001). Therefore, the dose of 0.5 mg of Cr improved energy metabolism efficiency of ewes during high-demand periods. We concluded that the dose of 0.5 mg of Cr per animal per day altered energy metabolism during late pregnancy and lactation, and that doses above it altered phosphorus concentrations.
Exploring the Transition Phenomenon of “Song and Musical Play” in Infants
Authors: Ogane Hironobu , Ogane Kaname
Published: November 2022

There is a lack of research on the use of the still-face procedure to assess infants’ comfort and reengagement in stressful situations. As previous studies have already investigated the transitional phenomenon based on Winnicott’s theory, this study decided to use “stuffed toy” and “song and musical play” with the still-face procedure. It aimed to examine the transition phenomenon of infants in “song and musical play” and provide a new perspective on psychological support for infants. Infant responses and maternal availabilities were also analyzed. The study participants were 32 infants (M = 17.97 months, SD = 1.43) and their mothers (M = 32.28 years, SD = 2.96). The results showed that infants were receptive to the “stuffed toy” and displayed positive responses. Additionally, the appearance ratios of “song and musical play” imitations increased. This suggests that the infants used “song and musical play” to manage and control their affect in stressful situations. Furthermore, when the mothers exhibited maternal availability as an emotional rhythm, the infants’ responses became positive. Therefore, the infants demonstrated the transitional phenomenon to symbolize inner objects for social participation using “song and musical play” as the transitional object.
Görüntü İşleme Uygulamaları İçin Finsler Eğri Evrim Modeli İncelemesi
Authors: KILIC Haydar , CEYHAN Salim
Published: November 2022

Bu çalışmada Finsler geometrisi ile kurulan ve varyasyonlar hesabı ile eğri evrim modeline dönüşen Finsler eğri evrim modeli incelenecektir. Bu model, Riemann eğri evrim modelinde olduğu gibi sadece görüntü uzayındaki konumlar değil yönlerde dikkate alınarak anizotropik bir uzayda kurulmuştur. Model, görüntüye izotropik bir yapı olarak bakan Riemann modelinin aksine anizotropik yapı olarak bakarak daha esnek bir çalışma alanı sunar. Bu nedenle görüntü işleme üzerine çalışan araştırmacıların sıklıkla üzerinde çalıştıkları bir model haline gelmiştir. Bu çalışmada ele alınan Finsler eğri evrim modelinin matematiksel analizi kullanılarak gelecekteki görüntü işleme alanında yapılacak çalışmalara katkı sağlanması amaçlanmaktadır.
Permütasyon Entropi Tabanlı Karmaşıklık Analizi ile EEG İşaretlerinden Şizofreni Tespiti
Authors: POLAT Hasan
Published: November 2022

Şizofreninin (SZ) erken tanısı hastaların daha etkili tedavi görmelerine olanak sağlayarak, yaşam kalitelerini artırır. Ancak, hastalığın karmaşık ve heterojen bulguları erken klinik tanıları sekteye uğratmaktadır. Bu bağlamda elektroansefalogram (EEG), olası SZ için alternatif bir tanı aracı olarak kullanılmaktadır. EEG tekniğinin yüksek temporal çözünürlük sunmasından dolayı, bilişsel ve davranışsal süreçlerin kortikal aktivitelere yansımaları başarılı bir şekilde irdelenebilir. Bu çalışmada, EEG işaretlerinin permütasyon entropi (PE) tabanlı karmaşıklık analizi ile SZ anomalilerin sınıflandırılması ve değerlendirilmesi amaçlanmıştır. PE analizleri, SZ semptomları sergileyen 45 adölesan birey ile 39 sağlıklı katılımcıdan alınan EEG kayıtları üzerinde uygulanmıştır. Özellik çıkarımı için delta, teta, alfa, beta ve gama dalgaları olmak üzere tüm alt bantların PE değerleri hesaplanmıştır. Sınıflandırıcı model olarak ise çok katmanlı perseptron sinir ağları (MLPNN) kullanılmıştır. Sınıflandırma işlemi her bir elektrot için ayrı bir şekilde yürütülmüştür. Böylelikle, SZ tespitinde etkin kanallar belirlenmiş ve bu kanallara ilişkin kapsamlı istatistiksel analizler uygulanmıştır. Bulgular, SZ tespitinin P4 ve T6 elektrot konumlarından etkin bir şekilde yapılabileceğini göstermiştir. Sınıflandırma doğrulukları P4 ve T6 kanalları için sırasıyla %87.2 ve %86.8 olarak elde edilmiştir. Ayrıca, PE dağılımlarının istatistiksel sonuçları, gama aktiviteleri için SZ hastalarında karmaşık nörodavranışsal özelliklerin önemli ölçüde azaldığını göstermiştir.
Effects of Van der Waals Interaction and Hubbard Term Correction on First Principles Calculations of Structural and Lattice Dynamical Properties of AgCl
Authors: BULUT Pınar
Published: November 2022

Structural, dielectric, and lattice dynamical properties of AgCl in the rock-salt structure are studied using density functional theory within generalized gradient approximation(GGA) in Perdew-Burke-Erzhenhof(PBE) parametrization and plane-wave pseudopotential method. The effect of van der Waals interaction (vdW) and Hubbard-U is investigated in detail for the lattice parameters, bulk modulus, dielectric, and phonon properties and compared to available experimental measurements. It is found that, inclusion of vdW interactions together with Hubbard U parameter to the standard GGA-PBE (PBE+vdW+U) improved the agreement with experimental lattice constant and bulk modulus of rock-salt AgCl. Moreover, PBE+vdW+U method is also correctly describes the acoustic and transverse optical (TO) phonon dispersion relation curves. The large underestimation (15%) of GGA-PBE in the longitudinal optical (LO) modes with respect to experiment is also decreased to 5% within the PBE+vdW+U method. This work demonstrates the applicability and accuracy of the van der Waals interaction and Hubbard-U term in predicting the structural, dielectric, and lattice dynamical properties of AgCl in the rock-salt structure.
Ti/IrO2/RuO2 Anot ve Paslanmaz Çelik Katot Kullanılarak Elektrooksidasyon Prosesi ile Metilen Mavisi Boyası Giderimi: İşletme Parametrelerin Rolü
Authors: SÖZÜDOĞRU Onur
Published: November 2022

Bu çalışma, sentetik olarak hazırlanmış atık sudan Metilen Mavisi boyasının anot malzemesi olarak Ti/IrO2/RuO2 ve katot malzemesi olarak paslanmaz çelik kullanılarak laboratuvar ölçekli bir elektrooksidasyon prosesi (EOP) ile giderimini araştırmak için yapılmıştır. Atıksuyun başlangıç pH değeri (3.0, doğal pH (≈ 5.0), 7.0, 9.0 ve 11.0), akım yoğunluğu (1.0 mA cm-2, 1.5 mA cm-2, 2.0 mA cm-2 ve 2.5 mA cm-2), destek elektrolit türü (NaCI, KCI, Na2SO4 ve NaNO3) ve destek elektrolit konsantrasyonu (1.0 mM, 1.5 mM, 2.0 mM ve 2.5 mM) dahil olmak üzere proses değişkenlerinin Metilen Mavisi boya giderme verimliliği üzerindeki etkisi incelenmiştir. 30 dakikalık elektrokimyasal işlemde, Metilen Mavisi boyasının gideriminde en yüksek giderim (%78.31) doğal pH değerinde (≈5) elde edilmiştir. Destek elektrolit türü olarak %78.31’lik giderim verimi ile NaCI en iyi destek elektrolit olarak belirlendikten sonra, NaCI’nın konsantrasyonunun 1.0 mM’den 2.5 mM’ye çıkarılmasıyla giderim verimi %78.31’den %88.25’e kadar yükselmiştir. Giderimde etkisi incelenen son parametre olarak akım yoğunluğunun 1 mA cm-2’den 2.5 mA cm-2’ye artırılmasıyla Metilen Mavisi boya giderim verimi %78.31’den %88.98’e kadar artış görülmüştür. Deneysel sonuçlar Ti/IrO2/RuO2 anot kullanarak Metilen Mavisi boyasının etkin bir şekilde giderilmesinde elektrooksidasyon prosesinin uygunluğunu ortaya koymuştur. Özellikle dolaylı oksidasyonda Metilen Mavisi boyasının sadece redoks aracıları olarak görev yapan klorür iyonlarının varlığında elektroliz edildiği ve reaksiyonun klorür konsantrasyonundan ve uygulanan akım yoğunluğundan etkilendiği belirlenmiştir.
Academic Researcher Work and the Confusion of Public Authorities. A Bleak Outlook for the Consequences of the Higher Education Reform in Poland – Comparative Approach
Authors: Świstak M. , Smoleń P.
Published: November 2022

From the very beginning, it was assumed that the new regulation – Law on Higher Education and Science (LHES) would mark the implementation of a ground-breaking, comprehensive reform – “Constitution for Science.” It was emphasised that the project constituted the most extensive reform implemented within the framework adopted by the EC as the model for all large-scale systemic changes since the last thirty years. Unfortunately, the efforts made to date by the Minister of Finance and Minister of Science and Higher Education in the face of the many difficulties emerging at the meeting point between copyright, tax and education laws have to be deemed ineffective. Against the background of the analysed solutions in BRICS countries, the Polish solutions are the most far-reaching in terms of protecting the interests of academic teachers. They lead to a reduction of the tax burden (by applying 50% tax deductible costs) by exactly half. While the very idea adopted on the grounds of Polish legal solutions deserves a high assessment and may constitute an interesting model to be copied in the BRICS countries (as far-reaching benefits for university researchers), the manner of its introduction deserves criticism. The adopted legal basis, as shown in the study, is not internally coherent at the junction of tax law, copyright law and higher education law. In fact, they are even mutually exclusive. For this reason, the manner of proceeding with this legitimate regulation cannot be recommended in the BRICS countries.
Cadena de Suministro Sostenible en los negocios del sector plástico mediante la utilización de la Biotecnología
Authors: Altamirano Flores Ernesto , Tinoco Gómez Oscar Rafael , Samar Tarazon Diego , Tapia Landa Alejandro
Published: November 2022

Con base en la problemática del sector industrial, sobre la comercialización de plásticos, que se ha visto afectado por la implementación de la ley que restringe el uso y comercialización de plásticos de un solo uso a través de la implementación de la Ley N.º 30884 – “Ley que regula el plástico de un solo uso y los recipientes o envases descartables”; este artículo propuso la implementación de un nuevo modelo de producción en base al Lean manufacturing con enfoque biotecnológico en una Mype de la industria plástica. Por este motivo, se eligió un método de investigación transversal a la cadena de suministro con un enfoque sostenible mediante la aplicación de biotecnología. Esta técnica utiliza recursos naturales para elaborar productos sustitutos de los plásticos de un solo uso y lograr un producto sostenible. La metodología mpleada fue no experimental y descriptiva, elaborando una propuesta de alternativa sostenible en la producción de plásticos de un solo uso por plásticos biodegradables que cumpla con la metodología Lean manufacturing. Finalmente, la conclusión más importante de la investigación fue que, efectivamente, mediante la implementación de la metodología propuesta se redujo mermas y mejoró la rentabilidad.
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations
of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with
Ischemic Heart Disease
Authors: Zozina Vladlena I. , Shikh Evgenia Valerievna , Kondratenko Svetlana Nikolaevna , Melnikov Evgeny Sergeyevich , Kukes Vladimir Grigorievich
Published: November 2022

Background:

Despite CoQ10 being a powerful antioxidant and its redox state that may characterize the
body’s antioxidant system, the latter remains unstudied in patients with cardiovascular diseases.

Objective:

This prospective case-control study aimed to investigate the concentrations of ubiquinol, ubiquinone, total CoQ10 and its redox state in patients with ischemic heart disease (IHD) and arterial hypertension (AH) during standard therapy and with the additional prescription of CoQ10.

Objective:

This prospective case-control study aimed to investigate the concentrations of ubiquinol, ubiquinone, total
CoQ10 and its redox state in patients with ischemic heart disease (IHD) and arterial hypertension (AH) during standard
therapy and with the additional prescription of CoQ10.

Methods:

The study included 54 healthy individuals and 26 patients, who were divided into a control group receiving
standard therapy and a test group receiving CoQ10 in addition to standard therapy. Quantitative determination of
COQ10, ubiquinone and ubiquinol was carried out by HPLC-MS/MS.

Results:

It was found that the CoQ10 level in patients was significantly lower than in healthy individuals (on average
-32Δ%). In the test group, after treatment, the concentrations of ubiquinol (+53 Δ%), ubiquinone (-28 Δ%), total
CoQ10 (+27 Δ%) and redox state (+112 Δ%) were significantly different from the baseline, while in the control
group no significant differences were noticed. In the test group after treatment, the levels of total CoQ10 (+25 Δ%),
ubiquinol (+43 Δ%), and redox state (+86 Δ%) were statistically significantly higher than in the control group and
total CoQ10 concentration did not significantly differ from that in healthy individuals (-12 Δ%).

Conclusion:

The additional prescription of CoQ10 for patients with IHD significantly increases the level of total
CoQ10, which leads to the increase of body antioxidant potential.
Evaluation of the Effect of Enamel Deproteinization Combined with a Self-etching Primer on the Adhesion of Orthodontic Brackets: An In Vitro Study
Authors: de Araújo Ricardo Veiga , Coelho Amanda Santos , Fialho Tiago , Peloso Renan Morais , de Oliveira Renata Cristina Gobbi , Cotrin Paula , Neto Daniel Sundfeld , de Oliveira Ricardo Cesar Gobbi , Valarelli Fabricio Pinelli , Salvatore Freitas Karina Maria
Published: November 2022

Aim:

The study aimed to evaluate enamel deproteinization with sodium hypochlorite in the enamel conditioning using a self-etching primer for adhesion in orthodontic brackets.

Background:

The bonding in orthodontics plays a major role in the success of the treatment. The self-etching primers reduce the chair time and diminish the risk of saliva contamination.

Methods:

The sample comprised 80 bovines' incisors, divided into 4 groups according to the deproteinization process and adhesive system used: G1: enamel deproteinization + Transbond Plus self-etching primer + Transbond XT adhesive; G2: enamel deproteinization + 37% phosphoric acid + conventional primer + and Transbond XT adhesive; G3: Transbond Plus self-etching primer + Transbond XT adhesive; and G4: 37% phosphoric acid + conventional primer + Transbond XT adhesive. EMIC®DL 500 Universal Testing Machine was used for testing the shear bond strength of the samples.

Results:

Brackets bonded with self-etching primer showed greater adhesion force. The enamel deproteinization did not improve the bonding strength, regardless of the primer used.

Conclusion:

The deproteinization process does not improve the result of the adhesive bonding when using a self-etching primerin vitro.