bluuebunny/crossref_metadata_2025 huggingface dataset:
Molding of all-cellulose plates made of cellulose pulp extracted from citrus fruit residue
Authors: Nakagaito Antonio N. , Takagi Hitoshi , Watanabe Takumi
Published: January 2025

Cellulose is photosynthesized by plants from carbon dioxide and water, and it is the most abundant organic compound available. It is present in the plant cells as structural component in the form of elementary fibrils known as nanofibers. Cellulose nanofibers can be easily extracted from parenchyma tissues of agricultural waste. Although thin sheets made of cellulose nanofibers can be readily obtained by a papermaking method, thicker plates are difficult to make. Here we propose a papermaking-like method to fabricate 1 to 2 mm-thick plates from citrus fruit residue-derived cellulose pulp initially having a solids content of about 1%. The protocol is simple, easy, requires affordable devices and relies on water evaporation to consolidate the fibrils by hydrogen bond interconnections. The pulp morphology seems to consist mostly of cellulose nanofibers and the bending strength and modulus of obtained plates reached 190 ± 30 MPa and 9.6 ± 1.5 GPa, respectively, values that approach those reported in a previous study that molded microfibrillated cellulose but relying on a complex process. This streamlined protocol could be groundwork for further studies aiming the difficult task of molding cellulosic materials.
Effect of Curcumin on Nitric Oxide and Endothelin-1 Levels in L-NAME-Induced Preeclamptic Wistar Rat
Authors: Dewi Ratih Frastika , Rahardjo Bambang , Wiyasa I Wayan Arsana , Handayani Puspita , Prasetyorini Nugrahanti , Wibisono Hermawan
Published: January 2025

Preeclampsia is a pregnancy disorder marked by the onset of hypertension after the 20th week, posing risks such as cardiovascular disease. Curcumin, a commonly consumed herbal medicine, has been investigated as a potential antihypertensive agent in mouse models of preeclampsia. This study took place in the Bioscience Laboratory of Universitas Brawijaya from March to August 2023, employing a true experimental design with various groups of mice receiving different treatments. Nitric oxide (NO) and endothelin-1 (ET-1) levels were measured using calorimetry and ELISA. The rats were divided into five groups: positive control, negative control and P1, P2, and P3 as the treatment groups. Treatment grups received fifferent curcumin doses of 30mg/kgBW/day, 50mg/kgBW/day, and 100mg/kgBW/day for P1, P2, and P3, respectively. Data analysis using the One-Way ANOVA and Post Hoc LSD revealed that curcumin at 100mg/kgBW/day significantly increased the NO level of 47.75±22.6 and decreased the ET-1 level of 67.03±24.47 when compared to the positive control (p<0.05). However, the 30mg/kgBW/day and 50mg/kgBW/day doses did not significantly affect the NO and ET levels. In conclusion, curcumin supplementation shows positive effects on NO and ET-1 levels in L-NAME-induced preeclamptic Wistar rats, highlighting its potential as an effective intervention for managing this pregnancy-related disorder.
FORECASTING HARGA BAHAN PANGAN AKIBAT FENOMENA EL NINO DENGAN LINEAR SQUARE METHOD
Authors: Putri Z Rini Widia , Maududi Roni Al , Hartuti Purni Munah
Published: January 2025

Tujuan penelitian ini adalah untuk memprediksi harga bahan pokok (beras, minyak goreng, gula pasir, ayam potong, daging sapi, dan telur ayam ras) pada masa terjadinya fenomena El Nino tahun 2023 di Indonesia. Harga prediksi diperoleh dengan menggunakan Linear Square Method. Berdasarkan data harga periode Agustus 2022 - Agustus 2023 diperoleh persamaan tren Linear Square masing-masing bahan pokok. Selanjutnya, dilakukan perhitungan keakuratan peramalan dengan menghitung MAPE (Mean Absolute Percentage Error). Adapun harga prediksi bahan pangan pada bulan September 2023 secara berturut-turut adalah Rp 11.958,91; Rp 20.521,95; Rp 14.597,41; Rp 37.826,64; Rp 139.009,40; dan Rp 31.409,04. Hasil perhitungan keakuratan peramalan harga bahan pokok dibawah 10%, artinya menunjukkan kriteria peramalan yang sangat baik/ sangat akurat.
PENERAPAN METODE REDUKSI VARIABEL DALAM PENGOTIMALAN PENDAPATAN MINIMUM HASIL PRODUKSI BINGKAI FOTO
Authors: Safitri Elfira , Basriati Sri , Oktavia Dhea Rizki , Soleh Mohammad
Published: January 2025

Production is an activity that produces an object so that it is more useful in meeting needs. One shop that produces photo frame of various sizes is Terminal Photo Giant. The aim of this research is to determine the minimum income per day from photo frame production using the variable reduction method. The method used in this research is the variable reduction method. The variable reduction method produces an optimal solution with all decision variables in the form of integers without having to branch or add gomory constraints. Based on the result of research using the variable reduction method, Giant Photo Terminal produces a minimum of 4 units of 16 R size photo frames and a minimum of 3 units of 18 R size photo frames every day with a minimum daily income of IDR. 570.000.
Prediction of Solar Radiation Data for Garlic Production in Magelang Regency Using Long Short-Term Memory
Authors: Safrudin Muhammad Safrul , Sitanggang Imas Sukaesih , Adrianto Hari Agung , Aini Syarifah
Published: January 2025

Garlic importation in Indonesia is frequently carried out to meet the high domestic market demand. To reduce dependency on imports, the development of local garlic production is crucial. This study aims to determine the optimal solar radiation for garlic growth using the Long Short-Term Memory (LSTM) algorithm. This algorithm was selected due to its ability to analyze time-series data and predict long-term patterns. The LSTM model was trained with the Adam optimizer, using a configuration of 1000 epochs, a batch size of 6, and a dropout rate of 2.0 to prevent overfitting. The model evaluation results show an indicating good accuracy with a RMSE of 0.1020, a Mean Squared Error (MSE) of 0.0104, and a correlation coefficient of 0.740, although it still has limitations in capturing extreme data fluctuations. The study found that in Magelang Regency especially in the sub-districts of Windusari, Grabag, Ngablak, Pakis, Dukun, Kaliangkrik, and Kajoran have optimal solar radiation for garlic cultivation between March and May, with a radiation range of 380 W/m² to 440 W/m². These findings provide valuable guidance for farmers in determining the optimal planting period, potentially enhancing local garlic production and reducing import dependency.
Relationship between ZHX2 Expression and VHL Gene Alteration in VHL-associated and Sporadic Hemangioblastomas of the Central Nervous System
Authors: Kanno Hiroshi , Nakahara Kimihiro , Yamada Sachiko , Fujii Satoshi , Murata Hidetoshi , Yamamoto Tetsuya , Hasumi Hisashi , Yao Masahiro
Published: January 2025

Central nervous system hemangioblastoma (CNS-HB) is the most common manifestation of von Hippel–Lindau disease (VHL). The main axis of the CNS-HB pathway is the VHL-HIF signaling pathway. Recently, we proposed an alternative VHL-JAK-STAT pathway in CNS-HB. In contrast, the VHL substrate transcription factor zinc fingers and homeoboxes 2 (ZHX2) have been identified as the oncogenic drivers in VHL-deficient clear cell renal cell carcinoma (RCC). However, ZHX2 expression in CNS-HB has not been previously reported. Furthermore, the VHL-ZXH2-NF-κB signaling pathway in CNS-HB remains unresolved. In this study, we aimed to investigate ZHX2 expression and VHL gene alteration in CNS-HB and propose the role of ZHX2 in CNS-HB. Using the MACS method, Scl+ hemangioblastoma-like cells were isolated from multipotent nestin-expressing stem cells. The ubiquitination of ZHX2 in these cells and the immunoprecipitation between ZHX2 and VHL were investigated. In addition, the VHL genes of patients with hemangioblastoma were analyzed. ZHX2 expression in CNS-HB tissues was examined by immunohistochemistry and western blotting. In addition, VHL gene mutations in CNS-HB were analyzed by sequencing. The association between ZHX2 expression and VHL gene mutation was analyzed. ZHX2 was ubiquitinated in Scl+hemangioblastoma-like cells after the transfer of the VHL expression vector into these cells. ZHX2 expression in these cells was well detected before transfer but disappeared after the transfer. ZHX2 expression was detected in 18 of the 21 CNS-HB tissues by immunoblotting and/or immunohistochemistry. Sporadic CNS-HB showed weak expression, whereas VHL-related CNS-HB showed moderate or strong expression. In particular, CNS-HB with severe VHL gene mutations, including large deletions, showed strong or moderate ZHX2 expression. The association between VHL gene mutation and ZHX2 expression revealed a significant correlation between VHL gene alteration severity and the level of immunoblotting (P < 0.05). In conclusion, the severity of VHL gene alteration correlates with the level of ZHX2 expression. ZHX2 is predominantly expressed in CNS-HB, especially in VHL-related cases with severe VHL gene alterations, suggesting a potential role in tumorigenesis and proliferation of CNS-HB.
Specific Non-Coding RNAs Involve in and Regulate the Transcriptional Network during Keloid Formation
Authors: Zhang Xun , Song Linlin , Ma Yong , Zhou Zifu , Luo Qiyun , Zhang Juan , Yang Yaozhu , Liu Lei , Guan Lifeng
Published: January 2025

Keloid formation is an undesirable outcome of wound healing and is detrimental to patients' physical and mental health, while the molecular regulators of its pathogenesis, especially non-coding RNAs (ncRNAs), are largely unknown. In this study, we integrated and analyzed RNA-seq and miRNA microarray datasets of skin samples from keloid-prone and healthy normal individuals to detect the dysregulated long ncRNAs (lncRNAs) and miRNAs. We excavated 583 and 104 keloid-specific lncRNAs and miRNAs, respectively. Moreover, the molecular functions of these ln-cRNAs and miRNAs are all related to ossification. Next, we constructed the relationship between lncRNAs and immune cell infiltration, and found the macrophages, NK cells, and dendritic cells were specifically dysregulated in keloid-prone or normal groups during wound healing. We constructed the potential regulatory network between these cell types and 20 dysregulated lncRNAs, suggesting their regulatory function in keloid formation. At last, we constructed the competitive endogenous RNA network and found two hub lncRNAs and five miRNAs, including DLEU1 and SLC25A21-AS1, miR-197-5p, miR-940, miR-6765-5p, miR-711, and miR-4284, which were highly dysregulated during keloid formation. In summary, these results demonstrate that lncRNAs and miRNAs play important roles and form a regulatory network in the pathogenesis, immune infiltration, and development of keloid formation.
Experimental investigation of the effect of train load on mechanical properties of rock
Authors: Tian Hongming , Zhang Tao , Xu Yulong , Tan Xianjun , Shu Xiaoyun , Yang Chenming
Published: January 2025

Serious inverted arch structural problems have been observed in some heavy-haul railway tunnels. To identify the causes of these structural issues, a series of compression tests were conducted to investigate the effect of train load on the mechanical properties of surrounding rock. Numerical analysis of the dynamic response of the tunnel to the heavy-haul train load was performed to obtain the frequency and amplitude of dynamic stress in the rock. Then the dynamic stress was applied to the sandy shale rock in the compression tests. The test results showed that after applying 300,000 cycles of train load, the elastic modulus and peak strength of the rock remained nearly constant. This indicates that the degradation of the surrounding rock due to train load is not a primary factor in the invert arch structural problems observed during the initial stage of heavy-haul railway operation.
A comprehensive review of the characterization of real numbers
Authors:   Universidade Federal da Integracao Latino-Americana (UNILA), Instituto Latino-Americano de Ciencias da Vida e da Natureza (ILACVN), Foz do Iguacu-Paraná, Brasil., Martínez León Víctor Arturo , Bloot Rodrigo , de Oliveira Ana Letícia
Published: January 2025

The real number system is a fundamental tool for rigorous demonstrations of the differential and integral calculus results. Even after a century of formalization on solid foundations, discussions about the construction of this field are generally omitted in advanced courses such as Real Analysis. In the present work, we present a comprehensive review on the construction and characterization of the real numbers field. The presentation focuses on the construction through Cauchy sequences of rational numbers. The notion of completeness is delimited differently from completeness when Dedekind’s cut construction is used. The results indicate Q and R Archimedean as a necessary condition for these two notions of completeness to be equivalent.
To illustrate this, inspired by the work of Leon W. Cohen and Gertrude Ehrlich, we present an example of a Cauchy-complete non-Archimedean ordered field in which the supremum axiom is not equivalent to the nested intervals principle.
Organização da Revista
Authors: Amigos da Natureza ANAP -
Published: January 2025

ORGANIZAÇÃO ANAP – Associação Amigos da Natureza da Alta Paulista  CONSELHO ADMINISTRATIVO Allan Leon Casemiro dos SantosAna Paula Miranda dos SantosSandra Medina Benini  CONSELHO EDITORIAL Allan Leon Casemiro dos SantosAna Paula Miranda dos SantosElisângela Medina BeniniLeonice Seolin DiasMaria Betânia Moreira AmadorSandra Medina Benini  E-MAIL DE CONTATO anapbrasil@amigosdanatureza.org.br
A Influência dos Indicadores de Meio Ambiente na Saúde Pública
Authors: Costa Laura Meira , Silva Thaísa Leal da
Published: January 2025

El proceso de urbanización acelerada y desordenada de los centros urbanos puede resultar en varios impasses en el ámbito ambiental, impactando directamente la salud pública y obstaculizando el desarrollo de las ciudades. En este sentido, el objetivo de este artículo es analizar los indicadores ambientales urbanos de las capitales del Sur de Brasil, con base en el Ranking de Ciudades Inteligentes Conectadas (RCSC), además de investigar sus impactos en la salud pública para identificar negativos y positivos. puntos en relación a las ciudades analizadas. En la metodología de la investigación, inicialmente se realizó una revisión bibliográfica sobre los temas de indicadores urbanos, ciudades inteligentes, saneamiento ambiental y salud pública, seguida de una comparación de indicadores ambientales urbanos en Porto Alegre-RS, Florianópolis-SC y Curitiba-PR según al Ranking de Ciudades Inteligentes Conectadas de 2021, 2022 y 2023. A partir de los resultados se pudo observar el desarrollo urbano de los municipios a lo largo de los años analizados, así como analizar el impacto de los indicadores en la salud pública y los resultados de Actuaciones urbanísticas realizadas en el contexto del medio ambiente o falta del mismo. Además, se determinó la relevancia de la recolección de datos respecto de indicadores urbanos, herramientas relevantes para la planificación y desarrollo de las ciudades, así como determinantes en el desarrollo de mejoras orientadas al medio ambiente de las ciudades.
Determinação das principais referências no desenvolvimento de produtos utilizando materiais descartados e alinhados com os conceitos da economia circular
Authors: Contador Felipe Augusto , Oliveira Leonardo Biesek de , Tortato Ubiratã , Canciglieri Junior Osiris
Published: January 2025

La capacidad de los vertederos del planeta se alcanzará en unos años debido a la aceleración del consumo de bienes y al enorme desperdicio inmediato de alimentos y productos (VAPNIK, 2020). Reutilizar recursos, utilizar logística inversa, utilizar ingeniería inversa y crear artículos remanufacturados son pasos necesarios para evitar esta calamidad. Este estudio utiliza una revisión sistemática de la literatura junto con un análisis de contenido crítico para identificar investigadores y autores clave, sus contribuciones y sus limitaciones con respecto al desarrollo de productos sustentables construidos o fabricados a partir de materiales reciclados (residuos). La selección de las preguntas de investigación, así como los términos y patrones de búsqueda utilizados en las bases de datos científicas para encontrar publicaciones relevantes, sirvieron de base para la revisión sistemática. Las búsquedas iniciales en bases de datos científicas arrojaron 6.691 artículos seleccionados. Después de algunos pasos de selección, 14 artículos fueron considerados los más relevantes para el tema de estudio sugerido, luego de ser sometidos a un análisis exhaustivo y a criterios de inclusión/exclusión. Los resultados de la revisión sistemática de la literatura fueron validados mediante un análisis de regresión. La investigación produjo una descripción detallada de los trabajos científicos sobre el tema de investigación publicados en los últimos diez años. Se amplió la comprensión de conceptos, enfoques, tecnologías y metodologías, así como sus aplicaciones y limitaciones en la resolución de problemas en el proceso de desarrollo de productos utilizando materiales desechados y principios de economía circular, identificando las investigaciones y autores más recientes y pertinentes.
La histÃ²ria de les dones i el gÃ¨nere
Authors: autores Varios
Published: January 2025

Quaderns de la Igualtat Ã©s una iniciativa de l'Observatori de la Igualtat de la Universitat Rovira i Virgili. Aquesta publicaciÃ³ representa la materialitzaciÃ³ de diverses mesures previstes al Pla d'igualtat de la URV (2007-2010), en quÃ¨ es plasma el compromÃ­s de la Universitat amb els valors de la igualtat i la no-discriminaciÃ³. Quaderns de la Igualtat vol ser un espai que serveixi per difondre l'activitat investigadora en matÃ¨ria de polÃ­tiques d’igualtat per raÃ³ de gÃ¨nere i aspira a facilitar a la comunitat acadÃ¨mica i cientÃ­fica una nova eina al servei de la transferÃ¨ncia de coneixement sobre dones i feminisme.
Higher education and COVID-19: An overview of the most important challenges
Authors: Mahdieh Motie , Seyed Meysam Mousavi , Zahra Sarabandi , Reza Dehnavieh , Khalil Kalavani
Published: January 2025

The COVID-19 pandemic has caused many disruptions in face-to-face learning, and the use of distance learning has affected all students and teachers [1]. There are a few quantitative studies conducted on the consequences of the COVID-19 virus and its impact on indoors environments such as university.
Automated sample detection (slide) and tiled Z-stacks v1
Authors: Airey Joe
Published: January 2025

This is a conditional imaging routine written using the JOBs module within Nikon's NIS elements software (version 6.10.01) on a Ti2-E widefield microscope. The JOB is designed to scan over a cover slip at low magnification, automatically find the sample (such as tissue sections) and then collect 3D data (Z-stacks) which tile across the detected sample. The user needs to input their desired color channels and magnification at the start of the JOB. This script can run on confocal with minor modification.
Bacterial SYBR-Cell Staining and Counting with the Attune Flow Cytometer v1
Authors: Mars Maggi
Published: January 2025

SYBR Cell staining in MICO lab
Electrical Characteristics and Peculiarities of Formation of Type II InAsSb/InAsSbP Heterostructures
Authors:   ITMO University, Russia, Kirilenko I.D. , Ruzhevich M.S. ,   ITMO University, Russia, Bazhenov N.L. ,   Ioffe Institute, Russia, Tomkovich M.V. ,   Ioffe Institute, Russia, Romanov V.V. ,   Ioffe Institute, Russia, Moiseev K.D. ,   Ioffe Institute, Russia, Mynbaev K.D. ,   ITMO University, Russia,   Ioffe Institute, Russia
Published: January 2025

This article presents the results of a study of current-voltage (I–V) characteristics of InAsSb/InAsSbP heterostructures with an InSb content in the InAsSb active region 0.06 and 0.09. Using these results, the results of electroluminescence studies, and the data of energy-dispersive X-ray spectroscopy obtained for InAsSbP films grown on InAs(Sb), it is shown that the peculiarities of formation of the InAsSb/InAsSbP heterointerface via the method of metalorganic vapor phase epitaxy can lead to the development of a type II heterojunction. At temperatures T ≤ 170 K, this is manifested in specific values of both the energy of electroluminescence spectrum maximum and the I–V cutoff value.
Effect of Plastic Deformation on the Structure and Properties of the Bioresorbable Zinc Alloy Zn-0.8Li-0.1Mn
Authors:   Ufa University of Science and Technology, Russia, Kulyasova O.B. , Sirazeeva A.R. ,   Ufa University of Science and Technology, Russia, Aksenov D.A. ,   Institute of Molecule and Crystal Physics UFRC RAS, Russia, Bolshakov B.O. ,   Ufa University of Science and Technology, Russia, Khafizova E.D. ,   Ufa University of Science and Technology, Russia, Parfenov E.V. ,   Ufa University of Science and Technology, Russia
Published: January 2025

The study of bioresorbable alloys is a relevant and promising area. Zinc alloys, in particular, are very promising for bioresorbable applications since zinc is an inexpensive and widely available material. In this paper, studies of the effect of plastic deformation by rolling on the zinc alloy Zn-0.8Li-0.1Mn are conducted. This alloy demonstrates high mechanical properties as a result of hot rolling treatment: ultimate tensile strength and yield strength are 525 MPa and 445 MPa, respectively, and elongation is 7%. The alloy structure is examined using modern methods such as scanning electron microscopy and electron backscattering diffraction. The results of the study can be useful for further research in the field of new materials development, as well as for the practical application of zinc alloys in various industries.
Effect of Aluminum Content on Lattice Parameters and Unit Cell Volume in Bulk Crystals β-(AlxGa1–x)2O3
Authors:   ITMO University, Russia, Bauman D.A. , Panov D.I. ,   ITMO University, Russia, Spiridonov V.A. ,   ITMO University, Russia, Ivanov A.Y. ,   ITMO University, Russia, Yagovkina M.A. ,   Ioffe Physical-Technical Institute RAS, Russia, Romanov A.E. ,   ITMO University, Russia,   Ioffe Physical-Technical Institute RAS, Russia
Published: January 2025

The article studies the influence of aluminum on the lattice parameters and the unit cell volume of the binary solid solution β-(AlxGa1–x)2O3. The aluminum content is determined by energy-dispersive X-ray spectroscopy. The lattice parameter values are calculated using X-ray diffractometry data. The diffraction patterns show peak broadening and shift to higher angles with increasing aluminum content. It is shown that when the aluminum fraction x changes from 0 to 0.25, the lattice parameters decrease linearly. This is consistent with Vegard’s law for solid solutions. The decrease in cell volume is physically related to the fact that aluminum has a smaller ionic radius than gallium, and the Al–O bond length is shorter than Ga–O one.
Transformational Party Leaders: Determinants of Leadership Style Assessment in Central and Eastern Europe
Authors: Gherghina Sergiu
Published: January 2025

The literature discussing leadership style identifies great variation between contemporary party leaders. While much attention is devoted to their actions, portrayal in the media, and relationships with their followers, there is limited analysis of which factors make a party leader transformational or transactional. This article addresses this gap in the literature and seeks to identify the characteristics of the party leaders or of the party to which they belong which lead party members to evaluate them on the transactional–transformational continuum. It uses original survey data from a modified version of the Multifactor Leadership Questionnaire. The analysis includes 12 political parties with parliamentary representation from Bulgaria, Hungary, and Romania between 2004 and 2018. The findings illustrate that members perceive as more transformational the first leaders of the party, those who have won competitive internal elections, and those with extensive political experience within the party.
Archival Certification Is One Piece of the Professionalization Puzzle
Authors: Dominick Emily Hughes , Flynn Rosemary Pleva , Oestreicher Cheryl , Sternberger Katy , Sly Margery N. , Linn Mott , Schaad Gerrianne , Baker Dara
Published: January 2025

In response to Ashley Todd-Diaz and Alex H. Poole's 2022 article published in American Archivist, “Who Is This Godot? The Academy of Certified Archivists and Graduate Archival Education,” the Academy of Certified Archivists (ACA) affirms the continuing relevance of archival certification and its place in the profession. ACA outlines its ongoing work to engage members, support graduate archival education, and further the discussion surrounding professionalization of the archives field. Based on themes that arose from ACA board discussions and a member forum, the authors discuss how certification complements graduate education; address how ACA values collaboration; explain how the certification examination is a valid and reliable measure of archival knowledge; consider how certification is a personal and professional investment; and affirm that certification is a worthwhile and relevant credential that enhances archivists and the profession.
Bacteriemias asociadas a dispositivos vasculares en recién nacidos con patologías quirúrgicas gastrointestinales. Unidad de Cuidados Intensivos Neonatales, Hospital Santísima Trinidad. 2019 - 2021
Authors: Aranda Cinthia
Published: January 2025

Introducción: La bacteriemia asociada a dispositivos intravasculares en neonatos con patología quirúrgica abdominal constituye una de las infecciones nosocomiales más frecuentes.
Objetivo: Determinar la frecuencia de bacteriemias relacionadas a dispositivos vasculares en neonatos con patología quirúrgica gastrointestinal en un servicio de neonatología entre 2019- 2021.
Materiales y métodos: Estudio observacional, retrospectivo. Muestra constituida por fichas clínicas de pacientes con patologías quirúrgicas seleccionadas (atresia esofágica, atresia intestinal, gastrosquisis, onfalocele, malformación anorrectal, enfermedad de Hirschsprung), expuestos a dispositivos intravasculares que presentaron bacteriemia. Se utilizó estadística descriptiva.
Resultados: Se incluyeron 99 neonatos, 17 presentaron bacteriemias, (total 29 eventos de bacteriemias relacionada a catéteres). 53% de sexo masculino, media del peso al nacer: 2615 g (1500 a 3550 g); media de edad gestacional: 36,5 semanas. La atresia intestinal fue la malformación congénita más frecuente (35.2%).
Entre los factores de riesgo asociados, el 47% de los pacientes requirieron 2 o más cirugías mayores; el tiempo medio de ARM varió de 2 a 104 días (media 23.8 días); 100% recibieron NPT, 52.9% por >28 días. Los dispositivos vasculares centralizados fueron utilizados por >28 días en el 52.9 % de los casos, (media 54,5 días). El tiempo de estancia hospitalaria fue >28 días en el 88.2% y la letalidad fue del 47%.
El total de días de uso de catéter fue: 2350. Se identificaron 29 infecciones asociadas al uso de los catéteres, siendo la tasa de incidencia de 12,3 por 1000 días de exposición de catéter venoso central y 29% por paciente expuesto. Los agentes etiológicos más frecuentes fueron: Staphylococcus coagulasa negativo (62%), K. pneumoniae 17,2% y C. albicans 10,4%.
Conclusión: La bacteriemia asociada a dispositivos vasculares en RN con patologías quirúrgicas gastrointestinales presentó elevada incidencia. Se deben implementar y supervisar medidas estratégicas de prevención que permitan mejorar el pronóstico y calidad de vida a estos pacientes.
Evidencias psicométricas de la Escala de Impacto de Eventos (IES-6) en adolescentes peruanos
Authors: Baños-Chaparro Jonatan , Ynquillay-Lima Paul , Caycho-Rodríguez Tomás
Published: January 2025

Introducción: los síntomas del Trastorno de Estrés Postraumático (TEPT) es un problema de salud pública frecuente en población adolescente. La evidencia empírica demuestra que los acontecimientos adversos durante la adolescencia pueden afectar la adultez temprana y predecir diversos problemas psicológicos. La evaluación continua sobre el TEPT es fundamental para la prevención y resulta necesario la disposición de instrumentos psicológicos confiables y basados en evidencia.
Objetivo: analizar las propiedades psicométricas de la Escala de impacto de eventos-6 (IES-6) en población general adolescente.
Metodología: investigación instrumental, enfoque cuantitativo y transversal. Participaron 2877 adolescentes de Huancavelica, que contestaron el IES-6 y otros instrumentos psicológicos. Los análisis estadísticos se realizaron con el modelamiento de ecuaciones estructurales y teoría de respuesta al ítem.
Resultados: el IES-6 presenta adecuada evidencia de validez de contenido, estructura unidimensional, confiabilidad, invarianza de medición según sexo y relación con la ideación suicida, ansiedad generalizada y depresión. Los ítems 5 y 3 presentaron la mayor discriminación e información, además la escala resulta precisa para niveles altos del TEPT.
Conclusión: el IES-6 presenta adecuadas fuentes de evidencia de validez y resulta un instrumento útil para la evaluación de los síntomas del TEPT en adolescentes peruanos. Se recomienda su uso en la investigación y los programas de prevención y seguimiento de salud pública y educación.
Lokális fordulat a szolidaritásban : Lehetőségek és kényszerek az ukrajnai menekültek befogadásában
Authors: Feischmidt Margit , Zsigmond Csilla , Zakariás Ildikó , Zentai Violetta , Neumann Eszter
Published: January 2025

Tanulmányunkban azt vizsgáljuk, hogy az ukrajnai háború elől Magyarországra menekültek támogatásában a civil és önkormányzati szereplők közötti együttműködés és szövetségépítés hogyan járult hozzá a szolidaritási kapcsolatok létrejöttéhez és megerősödéséhez. Bemutatjuk, hogy a háború miatt menekülő emberek iránti szolidaritás hogyan szerveződött meg és maradt fenn. Továbbá azt vizsgáljuk, hogy milyen strukturális tényezők, kapcsolatok, erőforrások és diskurzusok járultak hozzá a – sok külföldi esetben korábban azonosított – lokális fordulat korlátozott magyarországi megvalósulásához. Bár vizsgálatunk elsősorban a helyi civil szereplőkre fókuszált, figyelembe vettük azt is, hogy a magyar állam és a nemzetközi segélyszervezetek hogyan vettek részt a menekültek iránti felelősség átruházásban. Elemzésünk azt is feltárja, hogy a magyarországi önkormányzatok milyen szerepet vállaltak az ukrajnai menekültek befogadásában, és hogy ez a tevékenység hogyan járult hozzá az önkormányzatok felelősségének újraértelmezéséhez.
AI-Driven Optimization Techniques for Evolving Software Architecture in Complex Systems
Authors: Richardson Nicholas , Kothapalli Srinikhita , Onteddu Abhishake Reddy , Kundavaram RamMohan Reddy , Talla Rajasekhar Reddy
Published: January 2025

This work uses AI-driven optimization to improve software design in complex systems by addressing scalability, flexibility, and performance while balancing conflicting goals. AI methods, including machine learning, reinforcement learning, and evolutionary algorithms, are studied to optimize architectural design and adaption in dynamic situations. The research synthesizes literature, case studies, and technical reports to assess AI-driven methodologies and find gaps in current practices using secondary data. AI approaches improve software system flexibility, scalability, and efficiency, especially multi-objective Optimization and hybrid methods. Data quality, computational costs, interpretability, and ethics still prevent mainstream usage. Policy implications emphasize the need for transparent, fair, and secure AI-driven optimization regulations. Addressing these difficulties and allowing responsible AI implementation requires promoting data governance, explainable AI standards, and business, academic, and government engagement. This paper emphasizes AI's transformational potential in software architecture evolution and calls for continuing research and policy creation to overcome present limits and lead future advances.
Type 1 myocardial infarction in a 27-year-old patient with substance abuse, IGM antibodies against borrelia burgdorferi and hypercholesterolemia: Case report
Authors: Anokhin Alexey , Stach Ksenija , Duerschmied Daniel , Sauter Reinhard , Langer Harald
Published: January 2025

Background: The overall incidence of hospital admissions because of myocardial infarction attributable to young patients seams to increase over the years. Myocardial infarction in young patients is a rare disease, it is necessary to identify young patients with a high risk profile to recognize and treat them in time.

Case Summary: We present a patient with an acute heart attack at a young age and several risk factors for a cardiovascular event, including multiple drug abuse and hypercholesterolemia. Additionally, the patient had a second-degree atrioventricular block and severely reduced pumping function in the echocardiography. Intriguing about this case is the exceptionally young age and the potential impact of the risk factors.

Discussion: This case illustrates that even young patients can experience an occlusive myocardial infarction and in the presence of cardiovascular risk factors, coronary heart disease should be considered even at a young age.
Qualitative Assessment of a Novel Intervention to Reduce Hospital Readmission Risk Among People with Diabetes
Authors: Tanner Samuel , Brzana Emily , Deak Andrew , Recco Dominic , Tivon Madeline , Dillard Felicia , Watts Samantha , Kondamuri Neil , Bass Sarah , Rubin Daniel
Published: January 2025

Purpose: To qualitatively assess a novel intervention, the Diabetes Transition of Hospital Care (DiaTOHC) Program, designed to reduce hospital readmissions within 30 days of discharge among people with diabetes.

Methods: In a separately reported randomized controlled trial of the DiaTOHC intervention, hospitalized people with diabetes were identified as high risk for 30-day hospital readmission using the Diabetes Early Readmission Risk Indicator (DERRI®). Of these, 58 participants were randomized to the intervention. After the 30-day intervention, participants and study staff completed semi-structured interviews until saturation was achieved, yielding 21 participant and 4 staff interviews. Each one underwent thematic analysis.

Results: Four themes were identified: (1) Participants were motivated to make lifestyle changes, (2) Weekly Navigator phone calls were an effective method to support participants, (3) The intervention improved some diabetes knowledge domains but not others, and (4) Perceived lack of control was associated with readmission. Participants with baseline hemoglobin A1C (A1C) ≥8% made more changes to their diabetes management due to the intervention but were less likely to review the educational materials and had more extreme blood glucose levels. Participants who completed fewer post-discharge phone calls were more likely to find the educational booklet helpful than those who completed more calls.

Conclusions: Education, care coordination, and follow up are key components of the DiaTOHC Program that may improve diabetes self-management after a hospitalization and reduce readmission risk.
A case of latent autoimmune diabetes of adult with systemic lupus erythematosus
Authors: Daga Subhashchandra
Published: January 2025

Systemic lupus erythematosus and latent diabetes mellitus are chronic systemic disorders that affect any part of the body. Both have autoimmune origins. However, their coexistence is rare. A fifty-five-year-old woman of average build presented at Kamshet Primary Health Centre with skin rashes. Her blood test was positive for antinuclear antibodies, and she was treated with hydroxychloroquine. The patient also had increased urination and blurring of vision. Her fasting blood sugar was 260 mg/dl; her HbA1c was high,12.2%, and her C-peptide level was low (1.67 ng/ml). Singly and in combination, oral antidiabetic drugs made no difference to blood sugar levels, but the insulin response was prompt. We report a case that had features of both type 1 and type 2 diabetes along with systemic lupus erythematosus.
Community health workers’ knowledge, attitudes, and perceptions of risk for COVID-19: A cross-sectional survey in Haiti, Malawi and Rwanda Community health workers’ perceptions of COVID-19 in Haiti, Malawi, and Rwanda
Authors: Dubique Kobel , Armbruster Stephanie , Baganizi Erick , Joseph Stefanie , Belizaire Nadege , Chery Maurice , Faure Peterson , Baptiste Jimmy , Demosthene Emmanuel , Gondwe Frank , Chabwera Benson , Musafiri Tumusime , Mugunga Jean , Barnhart Dale , Clisbee Mary , Hedt-Gauthier Bethany , Munyaneza Fabien
Published: January 2025

Background: Community health workers (CHWs) are a trusted source of health care information for rural communities in many low- and middle-income countries. This became particularly relevant during the COVID-19 pandemic when individuals had restricted access to facilities and required sufficient knowledge to prevent infection. This paper assesses CHWs’ level of knowledge, attitudes, and risk awareness towards COVID-19 and willingness for and concerns about vaccination against COVID-19 among CHWs in Rwanda, Malawi and Haiti.

Methods: Between June 2023 and October 2023, we surveyed 525 CHWs – 175 CHWs per country in Haiti, Malawi, and Rwanda – affiliated with 54 health care facilities. Data on CHWs’ demographics, COVID-19 knowledge, attitudes, risk perceptions, and vaccine intention were collected. Participants indicated on a Likert scale their perception of COVID-19 in terms of its risk-worry-severity-control. We analyzed mean trust scores, correct answer rates and answer frequencies and reported global p-values, assessing any difference and pairwise p-values, assessing country-specific differences, using rank-based and ANOVA tests.

Results: Across all countries, CHWs perceived COVID-19 as a relatively controllable disease of little worry and considered their risk of contracting the virus lower than or average as compared to other diseases. In Rwanda and Haiti, CHWs showed strong knowledge of COVID-19 and the COVID-19 vaccine (correct answer rate Rwanda: 87.5%; Haiti: 81.3%), while CHWs knew considerably less in Malawi (correct answer rate: 12.9%). The vast majority of CHWs believed COVID-19 presents a serious threat to the public (Haiti: n=168, 96.0%; Malawi: n=159, 91.0%; Rwanda: n=173, 99.0%) and were confident that their country would win the battle against the COVID-19 virus (Haiti: n=149, 85.0%; Malawi: n=133, 76.0%; Rwanda: n=171, 98.0%).

Conclusions: The knowledge of COVID-19 and the COVID-19 vaccine among CHWs, along with their attitudes and perceptions of the virus, varies across countries and is likely influenced by cultural and political factors. Given the CHWs’ roles to disseminate knowledge among communities in Haiti, Malawi, and Rwanda, targeted CHW education and communication training could improve community responsiveness in the future.
CARDIOVASCULAR OUTCOME IN TYPE 2 DIABETES AND ATRIAL FIBRILLATION- How to modify the increased cardiovascular risk?
Authors: Meinertz Thomas , Jäckle Angelika , Kuck Karl-Heinz
Published: January 2025

The increased cardiovascular risk in patients with type 2 diabetes mellitus (DM) is further augmented by the presence of atrial fibrillation (AF). Therefore, the treatment strategy should be directed at improving the metabolic situation – e.g. avoiding marked fluctuations of blood glucose levels – and eliminating AF. Some of the life-style modifications recommended for patients with type 2 DM – such as weight reduction, engagement in regular physical activity, and cessation of tobacco use – can decrease the susceptibility to AF. The first-line pharmacological therapy of type 2 DM is metformin which also decreases the susceptibility to AF by improving insulin sensitivity. The most effective add-on therapy, especially in diabetes with atrial fibrillation, are sodium-glucose cotransporter 2 (SGLT2) inhibitors, dapagliflozin and empagliflozin. These drugs have been shown to reduce hospitalization for heart failure, cardiovascular mortality and the risk of incident atrial fibrillation. A promising new agent is the non-steroidal mineralocorticoid receptor antagonist finerenone. It reduced cardiovascular death, and the risks of hospitalization and new-onset AF. Since the risk of stroke and thromboembolism is especially high in DM with AF, nearly all affected patients need anticoagulation. Direct oral anticoagulants are more effective and safer than vitamin K antagonists. Atrial fibrillation occurs in type 2 DM despite optimal treatment of metabolic and clinical risk factors. In the past, antiarrhythmic drug treatment was used with limited success. In contrast to antiarrhythmic drug therapy, catheter ablation is an effective and safe treatment modality for the restoration of sinus rhythm. Since the long-term arrhythmia-free survival after catheter ablation is lower among patients with type 2 DM, individual ablation strategies are required in some of these patients. In summary, DM patients with AF require optimal treatment of metabolic risk factors, concomitant diseases, and specific strategies to prevent AF.
Advances in Stem Cell Therapy for Type 2 Diabetes Mellitus
Authors: Wehbe Tarek
Published: January 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion, leading to persistent hyperglycemia. Conventional treatments, including lifestyle modifications and pharmacotherapy, often fail to achieve optimal glycemic control and prevent complications. Recent advances in stem cell therapy offer promising avenues for T2DM management. This review discusses the efficacy of mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) in reducing blood glucose levels, improving Glycated Hemoglobin (HbA1c), and mitigating microvascular and macrovascular complications. Furthermore, we highlight recent innovations in 3D bioprinting and gene therapy that enhance stem cell applications in T2DM.
The US CDC, Veterans Administration, Law Enforcement and The Opioid Crisis -- Incompetence or Bad Faith?
Authors: Lawhern Richard
Published: January 2025

At age 80, I am a widely published healthcare writer, with over 250 papers, articles and interviews in peer reviewed journals and mass media during the past 28 years. My beat is public health policy for treatment of severe pain.

I am motivated. My wife of 45 years is a chronic pain patient. I hear from hundreds of others like her every week. From extensive research, I am convinced that “everything the government thinks it knows about the opioid crisis is wrong.” For more than a decade, the US public has been hearing that prescription opioid pain relievers are always and forever a “BAD THING.” Doctors and Big Pharma companies are supposedly responsible for an epidemic of addiction and drug overdose deaths. However, patients are being denied pain care all across America. Doctors are being sent to prison for imagined “offenses” that harmed not one patient.

The US Centers for Disease Control and Prevention, the Veterans Administration, and US law enforcement (Drug Enforcement Administration) have chosen to “pile on” this catastrophe. They simply assume without supporting data that doctors are guilty of causing widespread addiction and overdose in patients who are treated with opioid pain relievers. Their “solution” for this mess is to deny pain relief to people in agony and to persecute their healthcare providers on unscientific innuendo.

I believe these Agencies knew they were lying before they published their restrictive prescribing guidelines. Despite widespread damage from their policies for millions of people denied safe and effective pain treatment, the Agencies continue defending themselves against public challenge by any means, fair or foul.
Improving patient outcomes: lessons learned from a new kidney biopsy program, a covid-19 era initiative
Authors: Courville Karen
Published: January 2025

Kidney biopsy is a critical diagnostic tool in nephrology, often requiring specialized expertise and infrastructure. Prior to the COVID-19 pandemic, our second-level hospital, located in a rural area of Panama, lacked the capacity to perform kidney biopsies in-house. Patients were referred to a distant tertiary care center, leading to delays and limited access to timely diagnosis.

The COVID-19 pandemic disrupted healthcare systems worldwide, exacerbating these challenges. To address this, our hospital implemented an in-house kidney biopsy program. Over the course of the pandemic, we performed our first 30 kidney biopsies, and through the continuing of the program, it has enabled us to characterize a wide range of glomerular pathologies, including nephrotic and nephritic syndromes, with our over more than 100 kidney biopsies.

Our study evaluated the impact of this program. We observed a significant increase in the number of kidney biopsies performed post-implementation, with a focus on timely diagnosis and targeted treatment. Additionally, we found that in-house biopsies reduced costs associated with patient transfers and improved patient outcomes, particularly in terms of timely initiation of renal replacement therapy.

The COVID-19 pandemic served as a catalyst for innovation and adaptation in healthcare delivery. By sharing our experiences, we hope to inspire other healthcare institutions to consider similar initiatives and contribute to the advancement of nephrology care, especially in resource- constrained settings.
Infertility Among South Asian Women in the U.S.: Gynecologic Diagnosis and Future Risk of Chronic Disease
Authors: Nagaraj Nitasha
Published: January 2025

This study explores the intersection of gynecologic disorders, infertility, and chronic diseases among South Asian American women, an under-researched population. Using data from 2,677 participants in a web-based survey, we examined the prevalence of infertility, gynecologic conditions (uterine fibroids, endometriosis, and polycystic ovary syndrome [PCOS]), and their associations with chronic health outcomes, including type 2 diabetes (T2DM), obesity, hypertension, and gestational diabetes (GDM). Multivariate logistic regression models adjusted for age, education, and employment status were used to assess these relationships.
Redundant Data Center Planning for Universities
Authors: Çapalı Veli , Sümer Kadir , Ersoy Mevlüt
Published: January 2025

During the Covid-19 pandemic period, when remote education and working from home came to the fore, the importance of university information and remote education systems in this process has emerged. The digital transformation process and business continuity in the information technology infrastructure has been of great importance in terms of the services provided to students and staff during the pandemic period. The need for infrastructure for areas such as automation systems, electronic document management systems, online education and learning management systems has suddenly increased during the pandemic process, and it has been a situation faced by universities to meet this need and ensure business continuity by data centers. Because; various applications were made for the criteria to be considered in the design of the data center, redundant infrastructure, security, and later flexibility and business continuity. In this study, Suleyman Demirel University data center planning and business continuity application is given by presenting how the three-location redundant data center planning should be done according to TIER and ISO22301 standards.