bluuebunny/crossref_metadata_2025 huggingface dataset:
COMBINED NS5A & NS5B NUCLEOTIDE INHIBITOR THERAPY FOR PATIENTS WITH CHRONIC HEPATITIS C WITH STAGE 5 CHRONIC KIDNEY DISEASE ON HEMODIALYSIS
Authors: DEBNATH Prasanta , CHANDNANI Sanjay , RATHI Pravin , NAIR Sujit , PAWAR Vinay , CONTRACTOR Qais
Published: February 2020

ABSTRACT BACKGROUND: Hepatitis C virus (HCV) infection is the most common hepatotropic viral infection affecting the patients on maintenance hemodialysis. Treatment of chronic HCV infection in stage 4 and 5 CKD includes a combination of elbasvir/grazoprevir and glecaprevir/pibrentasvir, which are not available in many countries. OBJECTIVE: Hence, we have conducted this study to look for the safety and efficacy of sofosbuvir combination therapy in this difficult to treat population. METHODS: We conducted a single-center, prospective, open-label study in which Stage 5 CKD patients on maintenance hemodialysis with HCV infection. Total of 18 patients was included. sofosbuvir with daclatasvir or ledipasvir was used according to genotype for 12 weeks. HCV RNA, genotype, transient elastography (TE) was considered for every patient. HCV RNA was quantified at 4th week, 12th week and 12 weeks post-treatment to look for sustained virologic response (SVR 12). RESULTS: Infection due to genotype 1 was seen in 12 (66.7%) patients followed by genotype 3 in 4 (22.3%) with each patient of genotype 2 and 5. The median value of HCV RNA was 2,35,000 IU/mL. On TE, all had liver stiffness of <9.4 KPa. All patients had HCV RNA of <15 IU/mL at 4th and 12th week of treatment and 12 weeks post-treatment. No significant change in hemoglobin, eGFR and liver stiffness was observed. CONCLUSION: Full dose sofosbuvir i.e. 400 mg, in combination with NS5A inhibitors daclatasvir or ledipasvir is found to be safe and effective in patients with end stage renal disease, who are on maintenance hemodialysis.
ASSOCIATION OF IL-8 -251T>A (RS4073) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS BASED ON 33 CASE-CONTROL STUDIES
Authors: MOGHIMI Mansour , DASTGHEIB Seyed Alireza , HEIRANIZADEH Naeimeh , ZARE Mohammad , SHEIKHPOUR Elnaz , NEAMATZADEH Hossein
Published: February 2020

ABSTRACT BACKGROUND: The role of -251A>T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene in gastric cancer was intensively evaluated, but the results of these studies were inconsistent. OBJECTIVE: Therefore, we performed a meta-analysis to provide a comprehensive data on the association of IL-8 -251T>A polymorphism with gastric cancer. METHODS: All eligible studies were identified in PubMed, Web of Science, EMBASE, Wanfang and CNKI databases before September 01, 2019. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. RESULTS: A total of 33 case-control studies with 6,192 cases and 9,567 controls were selected. Overall, pooled data showed that IL-8 -251T>A polymorphism was significantly associated with an increased risk of gastric cancer under all five genetic models, i.e., allele (A vs T: OR=1.189, 95% CI 1.027-1.378, P=0.021), homozygote (AA vs TT: OR=1.307, 95% CI 1.111-1.536, P=0.001), heterozygote (AT vs TT: OR=1.188, 95% CI 1.061-1.330, P=0.003), dominant (AA+AT vs TT: OR=1.337, 95% CI 1.115-1.602, P=0.002) and recessive (AA vs AT+TT: OR=1.241, 95% CI 1.045-1.474, P=0.014). The stratified analysis by ethnicity revealed an increased risk of gastric cancer in Asians and mixed populations, but not in Caucasians. Moreover, stratified by country found a significant association in Chinese, Korean and Brazilian, but not among Japanese. CONCLUSION: This meta-analysis suggests that the IL-8 -251T>A polymorphism is associated with an increased risk of gastric cancer, especially by ethnicity (Asian and mixed populations) and country (Chinese, Korean and Brazilian).
REPRODUCTIVE ASPECTS IN BRAZILIAN CELIAC WOMEN
Authors: KOTZE Lorete Maria da Silva , MALLMANN Andyara , MIECZNIKOWSKI Rebeca C , CHRISOSTOMO Kadija Rahal , KOTZE Luiz Roberto , NISIHARA Renato
Published: February 2020

ABSTRACT BACKGROUND: Celiac disease (CD) is a chronic enteropathy in response to ingestion of gluten. CD was associated with gynecological disorders. OBJECTIVE: In this retrospective study, we aimed to investigate the age of menarche, age of menopause, number of pregnancies and abortions in Brazilian celiac patients. METHODS: We studied 214 women diagnosed with CD and as control group 286 women were investigated. RESULTS: Regarding the mean age of menarche, a significant difference was found (12.6±1.40 in CD and 12.8±1.22 years in healthy group; P=0.04). Regarding abortions, in CD women 38/214 (17.8%) and 28/286 (9.8%) in the control group reported abortion (P=0.0092, OR:1.98; CI95%=1.1- 3.3). There was no significant difference in the mean age of menopause nor number of pregnancies per woman. CONCLUSION: In this study, we found that celiac women had a higher mean age of menarche and higher risk of spontaneous abortions.
Sequential Application of Herbicides Alone and in Mixture With and Without Foliar Fertilizer after Pruning of Cassava Plants
Authors: COSTA N.V. , SALVALAGGIO A.C. , FERREIRA S.D. , BARBOSA J.A. , GIBBERT A.M.
Published: February 2020

ABSTRACT: A new cycle of growth begins after pruning of cassava, and weed control is necessary. Thus, this study aimed to evaluate the selectivity and efficiency of sequential application of herbicides alone and in mixture with and without of foliar fertilizer after pruning of cassava. Two experiments were carried out in a randomized block design with four replications. The treatments of Experiment 1 consisted of control without weeding; control with weeding; mesotrione; mesotrione/mesotrione; mesotrione + foliar fertilizer/mesotrione + foliar fertilizer; mesotrione/mesotrione + foliar fertilizer; mesotrione + clethodim; mesotrione + clethodim + foliar fertilizer/mesotrione + clethodim + foliar fertilizer; mesotrione + clethodim/mesotrione + clethodim; mesotrione + clethodim/chlorimuron; mesotrione + clethodim/chlorimuron + foliar fertilizer; mesotrione + clethodim + foliar fertilizer/chlorimuron + clethodim + foliar fertilizer; mesotrione + clethodim/chlorimuron + clethodim]. Treatments of Experiment 2 consisted of control without weeding; control with weeding; chlorimuron; chlorimuron + foliar fertilizer/chlorimuron + foliar fertilizer; chlorimuron/chlorimuron; chlorimuron + clethodim; chlorimuron + clethodim + foliar fertilizer/chlorimuron + clethodim + foliar fertilizer; chlorimuron + clethodim/chlorimuron + clethodim; chlorimuron + clethodim/mesotrione + foliar fertilizer; chlorimuron + clethodim/mesotrione; chlorimuron + clethodim + foliar fertilizer/mesotrione + clethodim + foliar fertilizer; chlorimuron + clethodim/mesotrione + clethodim. The doses of mesotrione, clethodim, and chlorimuron used in both experiments were 240, 120, and 20 g ha-1, respectively, while 2.5 L of the commercial product Amino Plus® was used as foliar fertilizer. The first application was carried out at 50 days after pruning and the second application at 22 days after the first application. In Experiment 1, the application of mesotrione, mesotrione/mesotrione, and mesotrione + clethodim/mesotrione + clethodim showed selectivity to cassava and were efficient in weed control. In Experiment 2, chlorimuron + clethodim/mesotrione, chlorimuron + clethodim + foliar fertilizer/mesotrione + clethodim + foliar fertilizer, and chlorimuron + clethodim/mesotrione + clethodim were efficient in weed control, but no treatment was selective. The addition of foliar fertilizer to the spray solution did not contribute to increase selectivity.
Application of Various Herbicides on Controlling Large and Narrow Leaf Weeds and Their Effects on Physiological and Agronomic Traits of Wheat
Authors: Bari A. , Baloch M.S. , Shah A.N. , Khakwani A.A. , Hussain I. , IQBAL J. , Ali A. , Bukhari M. A.
Published: February 2020

ABSTRACT: In order to examine application of various herbicides for controlling weeds in wheat crop, a field trial was conducted at the Agronomic Research Area, Faculty of Agriculture, Gomal University, Dera Ismail Khan, Khyber Pakhtunkhwa (KPK) during the year 2015-2016. The experiment was laid out in a randomized complete block design (RCBD) with split-plot arrangements having three replications. The main plot was comprised application time of herbicides while the use of herbicides was assigned to sub-plots. The data revealed that most of the weed parameters, physiological traits and agronomic attributes of crop plants were significantly affected by weed management practices including the use of herbicides at different time intervals over the weedy check. Hand weeding technique excelled all other weed management practices in almost all the parameters studied. This technique was found to be the most effective treatment against all prevailing weeds and obtained the highest grain yield of wheat under climatic conditions of Dera Ismail Khan.
Pollen Morphology of Some Turkish Salvia L. (Lamiaceae: Mentheae) Species
Authors: AKTA K. , ÖZDEMIR C. , ÖZKAN M. , BARAN P.
Published: February 2020

ABSTRACT: In this presented work, the pollen morphologies of twenty-one taxa, nine of them endemic from Turkey, belonging to the genus Salvia (Lamiaceae: sub-family Nepetoideae: tribe Mentheae: sub-tribe Salviinae), S. aethiopis L., S. argentea L., S. aytachii Vural & Adigüzel, S. blepharochlaena Hedge & Hub.-Mor., S. cadmica Boiss., S. ceratophylla L., S. cryptantha Montbret & Aucher, S. frigida Boiss., S. fructicosa Miller, S. halophile Hedge, S. napifolia Jacq., S. microstegia Boiss. & Bal., S. recognita Fisch. & Mey. S. sclarea L., S. smyrnaea Boiss. S. suffruticosa Montbret & Aucher, S. tchihatcheffii (Fisch. & Mey.) Boiss., S. tometosa Bertol, S. verbenaca L., S. viridis L., and S. wiedemanni Boiss. and collected throughout the Turkey, have been intensively studied by using light (LM) and a scanning electron (SEM) microscopy. The objectives of this study are to investigate the pollen morphologies of twenty-one taxa of Turkish Salvia (nine of which are endemic) and to present similar and different characteristics of the taxa. The investigated whole pollen grains had a structure of both isopolar and radial symmetry. Overall, types of aperture were mostly hexacolpate, but it was also determined that the aperture type of S. viridis was both hexacolpate and octacolpate. The pollen grains had characteristic shapes of spheroidal, suboblate, prolate and subprolate. The exine ornamentation was bireticulate and reticulate-perforate. It was determined by the results of palynological studies that pollen morphology changed amongst these studied taxa. As a conclusion, the results of the present study show that palynological characters such as pollen shape, polar axis length (P), equatorial axis length (E), aperture numbers and types and exine ornamentation, exhibit remarkable differences amongst the studied taxa.
Weed Interference in Okra Crop in the Organic System During the Dry Season
Authors: SANTOS R.N.V. , PIRES T.P. , MESQUITA M.L.R. , CORREA M.J.P. , SILVA M.R.M.
Published: February 2020

ABSTRACT: In organic systems during the dry season, competition of weeds with okra increases the critical period of interference of these species and yield losses. The objective of this research was to determine the critical period of weed interference in organic okra during the dry season in São Luís - MA. The experiment was conducted from October/2014 to January/2015 in randomized blocks, with four replicates. The treatments were the periods of 07, 14, 21, 28, 35, 42 days after the transplanting of the crop with control and coexistence of the infesting community. The species with the highest importance value index were Cynodon dactylon, Eleusine indica, Amaranthus spinosus and Commelina benghalensis. The CPWI was 04 to 53 days after transplanting and yield losses were 69.5%. The organic okra cropping system during the season dry should be free of weeds until the beginning of the harvest to avoid high yield loss.
Weeds Associated with Banana Crops in Magdalena Department, Colombia
Authors: QUINTERO-PERTÚZ I. , CARBONÓ-DELAHOZ E. , JARMA-OROZCO A.
Published: February 2020

ABSTRACT: This study was conducted to determine the richness and composition of weed communities associated with banana plantations in Magdalena department, Colombia. Between September 2016 and May 2017, a total of 164 hectares were assessed over four agroecological zones (Alta, Media, Baja and Norte); in each zone, three representative farms were selected where, through zigzag paths, botanical collections were made in cultivated lots. Information on life cycle, growth habit and origin of each species was included. The floristic composition was represented by 204 species distributed among 143 genera and 54 families. Poaceae, with 31 species, was the family with the highest species richness, followed by Fabaceae (12) and Asteraceae (11). From the total species recorded, 113 are perennial (55%) and 91 are annual (45%); 141 species are herbaceous (68%), 38 are climbers (20%), and 25 are arboreal or shrubby (12%). Native species predominate over introduced species. The species richness does not differ significantly between the sampling zones, but the weed community composition does. The presence of common species reported as important weeds worldwide was recorded in the four zones. However, some species were recorded in only one of the zones, generating a differential composition pattern. Comparison with local inventories showed changes in the composition of the weed complex over time. The presence of various species not previously considered weeds in the banana crops of this region is highlighted.
Weed Vegetation Structure in an Area of Organic Acerola Cultivation, Parnaíba, Piauí, Brazil
Authors: SOUSA P.H.S. , MENDES M.R.A. , VAL A.D.B. , TEIXEIRA M.C.S.A.
Published: February 2020

ABSTRACT: This study aimed to identify and quantify the weed species in an area of organic acerola cultivation in the Distrito de Irrigação dos Tabuleiros Litorâneos do Piauí (DITALPI) in Parnaíba, Piauí, Brazil. Phytosociological sampling was completed in the rainy season, before the farmers adopted management techniques for the plants. Thirty plots of 0.25 m2 were sampled. The plots were located between crop rows, which consisted of herbaceous-subshrub plants. The absolute and relative covers and the absolute and relative frequencies of each species were calculated based on the occurrence and cover of each species. In total, 25 species comprising 13 families were registered, among which the Poaceae family that presented the largest number of species. Commelina benghalensis occurred the most frequently overall. Shannon’s diversity index (H’) and evenness were calculated as 2.30 nats ind-1 and 0.69, respectively. Five species accounted for 79.33% of absolute cover at DITALPI. The species were distributed heterogeneously within the field, and Commelina benghalensis, Urochloa plantaginea, Panicum maximum, Amaranthus spinosus, Cynodonsp., and Cyperus aggregatus were the species most likely to infest the acerola crop. As DITALPI is an area of organic cultivation, understanding these species is essential to help farmers select the best form of control.
Toxoplasma gondii in cattle in Brazil: a review
Authors: Gomes Daniella Ferreira Cordeiro , Krawczak Felipe da Silva , Oliveira Cairo Henrique Sousa de , Ferreira Júnior Álvaro , Fernandes Éverton Kort Kamp , Lopes Welber Daniel Zanetti , Sevá Anaiá da Paixão , Gennari Solange Maria
Published: February 2020

Abstract Toxoplasma gondii is an apicomplexan protozoan that is frequently found in both humans and animals worldwide. The aim of this review was to list important aspects of Toxoplasma gondii infection in cattle in Brazil. The frequency of occurrence of T. gondii antibodies in Brazilian cattle ranges from 1 to 89.1%, depending on the region evaluated, based on data from 1978 to 2018. However, some characteristics of T. gondii infection in cattle remain uncertain, such as the role of meat intake in transmitting the parasite to humans. Most information regarding T. gondii infection among Brazilian cattle is limited to evaluations of the frequency of occurrence of antibodies. About 70% of the diagnoses of infection in these ruminants in Brazil are made via the indirect fluorescence antibody test (IFAT). Nevertheless, little is known about the population structure of this protozoan in cattle. It is necessary to expand the studies on toxoplasmosis in cattle, in order to better understand T. gondii infection in these animals and its implications for Brazilian public health.
Environmental drivers and composition of assemblages of immature odonates (Insecta) in a subtropical island in southern Brazil
Authors: Pires Mateus Marques , Siegloch Ana Emília , Hernández Malva Isabel Medina , Petrucio Maurício Mello
Published: February 2020

Abstract: Aim Describe the diversity of immature stages of Odonata (Insecta) in streams from a subtropical island in southern Brazil and investigate the influence of environmental variables on the composition of their assemblages. Methods Eleven low-order streams (1st to 3rd order) were sampled in two conservation units located in the island of Santa Catarina (southern Brazil) between 2010 and 2012. Immature specimens of Odonata were collected using a Surber sampler. The influence of water abiotic parameters and habitat structure (mesohabitats: riffle vs. pool areas, microhabitats: litter vs. stone substrates) on the composition of Odonata was tested through the seasons using ordination diagrams and redundancy analysis. Results Nine odonate genera from seven families were recorded in the study region. The genera Desmogomphus, Epigomphus (Gomphidae), Heteragrion (Heteragrionidae) and Perilestes (Perilestidae) have their first records described for the state of Santa Catarina. Additionally, biological notes are provided for other odonate genera concerning substrate use. The composition of Odonata communities changed over the seasons and they were influenced by water temperature and velocity. Additionally, odonate composition differed significantly between microhabitats (substrate type) and mesohabitats (riffle vs. pool areas) in the streams studied. Conclusions The lower genera richness of Odonata recorded in the island of Santa Catarina in relation to other Brazilian subtropical streams is probably associated with the insular condition of the study region. This study also demonstrated that substrate (organic and inorganic) and mesohabitat (riffle and pool) types were important drivers of the composition of the fauna of immature odonates, evidencing the role of climate and habitat structure in influencing subtropical stream insect communities.
Anti-PD1-Induced Immune-Related Adverse Events and Survival Outcomes in Advanced Melanoma
Authors: Suo Aleksi , Chan Yin , Beaulieu Carissa , Kong Shiying , Cheung Winson Y. , Monzon Jose G. , Smylie Michael , Walker John , Morris Don , Cheng Tina
Published: February 2020

Introduction

Objective response rates (ORR) appear to be higher in melanoma patients who develop immune-related adverse events (irAEs), but whether there is a similar association between irAEs and survival remains unknown.

Materials and Methods

Patients with advanced melanoma treated with single-agent pembrolizumab or nivolumab in the province of Alberta from June 2014 to May 2017 were identified through the provincial pharmacy database. Chart review identified and categorized all irAEs that occurred while on anti–programmed cell death protein 1 (PD-1) checkpoint inhibitors. The primary objective was to compare overall survival (OS) with patients who developed any irAEs versus those who did not. Secondary outcomes included progression-free survival (PFS) and ORR.

Results

Among 186 patients, any-grade and grade ≥3 irAEs occurred in 88 (47%) and 27 (15%) patients, respectively; one patient died of pneumonitis. In a landmark analysis excluding patients who died within the first 12 weeks, the median follow-up was 24 months, 20 months in patients without any irAEs and 26 months in patients with irAEs (p = .006). Median OS was 39 versus 23 months (hazard ratio [HR], 0.46; p = .001) for any irAE and no irAE, respectively, and median OS not reached versus 29 months for grade ≥3 irAEs and no grade ≥3 irAEs, respectively. In multivariate analysis, elevated lactate dehydrogenase correlated with reduced OS (HR, 2.34; p = .001), whereas each additional cycle of treatment received (HR, 0.94; p < .001) and development of grade ≥3 irAEs (HR, 0.29, p = .024) were significantly associated with longer OS.

Conclusion

Anti-PD-1–associated grade ≥3 irAEs in patients with advanced melanoma is associated with better patient outcomes, including overall survival.

Implications for Practice

Previous prospective randomized clinical trials demonstrate improved response rates in patients with melanoma who develop select adverse events. The current population-based real-world study in advanced melanoma reports an association with anti–programmed cell death protein 1 (PD-1)–induced grade ≥3 immune-related adverse events (irAEs) and better patient outcomes, including overall survival. These results suggest that irAEs may be a manifestation of a patient's ability to mount a systemic immune response from PD-1–directed therapies, which may be associated with therapeutic benefit. The finding of irAEs coinciding with clinical benefit from these therapies supposes that these events are, by and large, unavoidable, and the critical management of irAEs remains essential for optimizing patient outcomes.
How Do U.S. Global Systemically Important Banks Lower Their Capital Surcharges?
Authors: Rezende Marcelo , Berry Jared , Khan Akber
Published: February 2020

In this note, we examine whether and how U.S. G-SIBs adjust their systemic importance indicators to lower their surcharges.
The Object of Russian Criminology
Authors: Prozumentov Lev , Shesler Alexander
Published: February 2020

The authors analyze the content of the object of criminology, which includes criminality, criminalization of actions, decriminalization of actions, the personality of the criminal, determinants of crime, criminological prevention of crime. They support the definition of criminality according to which it is a social (socially dangerous, relatively mass, historically changing) and criminal law phenomenon that includes a system-forming aggregate of crimes and persons who have committed them in a certain territory within a certain period of time. The authors believe that the object of criminology should include the criminological conditionality of the existence or the change of the criminal law prohibition, while the object of the science of criminal law should include the social conditionality of establishing the criminal law prohibition as well as the legislative methodology of criminalizing and decriminalizing actions. It is stated in the article that the best approach to the personality of the criminal views this personality as an aggregate of social, biological and psychological qualities of the person who has committed a crime. The authors stress that the existence of criminality should be explained from deterministic positions which make it possible to show the diverse influence of many social phenomena on criminality. Criminality originates from its causes as a natural consequence, the conditions form or contribute to the emergence of the causes of crime, the factors create a certain favorable background for the existence of criminality. The authors describe changes in the action mechanism of general social determinants of crime under the influence of globalization. They begin to exercise their negative influence on a person not through small social groups in which socialization takes place, but directly, especially though the Internet. The authors state that the object of criminology is the criminological prevention of crime in the form of coercion not connected with the implementation of criminal law measures, as well as in the form of protecting the rights and lawful interests of a person and providing social and legal support.
FER and Manchzhou-Go: Historical Parallels
Authors: Sukhodolov Alexander , Lebedeva Alina
Published: February 2020

The article examines historical experience of the state and legal construction, the international status of the two political phenomena, that came to life on the geopolitical space in the first half of the 20th century, — Far Eastern Republic (FER) and Manchzhou-Go, known as non-recognized and puppet states or buffer zones. It uses such criteria of studying non-recognized states as historical prerequisites of establishment and stages of formation, internal structure and formation of statehood institutions, control over its own territory, international recognition. It pays particular attention to international ties with China which became an area of foreign-political interests of the Pacific Region countries.
The article makes a conclusion of existence of common ideas and regularities in arising and development such state formations. The Far Eastern Republic can be regarded as a prototype of Manchzhou-Go, while the «bufferism» as a unique feature inherent to the Far Eastern policy of the XX-th century.
Paternalism with Chinese Characteristics: Philosophical Aspects of Political Leadership in China's National Media Discourse
Authors: Lin Chuanzhao , Smirnova Olga
Published: February 2020

The article analyzes the main approaches to the study of such a phenomenon as political leadership, its understanding in the context of Chinese philosophy and also makes an analysis of presence of the political leadership topic in the national media discourse. In today’s context, political leadership plays a crucial role in development of each country, since in terms of globalization processes it is one of the key moments of the spread of state influence on society. Thanks to the media, the activities of the political leader become public, and China is no exception — here also the representation of political leadership occupies a prominent place in the national media discourse. The scientific novelty of the article lies in the fact that no philosophical aspects of political leadership in the national media discourse have been previously studied. The article also focuses on the influence of media discourse on the process of change in the perception of political leadership in China. The research methodology consists in the analysis of scientific publications and practical experience in the functioning of Chinese society. It also carries out a content analysis of media publications on a given problem. Based on the results of the analysis, it makes a conclusion that that the institution of political leadership in China has many specific characteristics arising from the doctrine of «paternalism with Chinese characteristics». It also confirmed the hypothesis that modern ideas about political leadership in China have a close relationship with Chinese philosophy and this relationship is traced in the national media discourse.
Prevalência de depressão e Síndrome de Burnout em anestesiologistas do centro cirúrgico de hospital escola
Authors: Hartman Beatriz Cristine , Furlan Letícia , Petterle Ricardo Rasmussen , Motter Arlete Ana
Published: February 2020

INTRODUÇÃO: A presença de Síndrome de Burnout (SB) e Depressão vêm aumentando devido às rotinas extenuantes vivenciadas pelos anestesiologistas. OBJETIVO: Identificar a prevalência de Depressão e Síndrome de Burnout em anestesiologistas e residentes desta especialidade médica do Centro Cirúrgico de um Hospital. MÉTODO: Estudo transversal, descritivo e exploratório. Participaram da pesquisa 51 profissionais, sendo utilizados dois questionários, ambos autoaplicáveis: os Inventários de Maslach Burnout (MBI) e Depressão de Beck, além de uma breve conversa a respeito da rotina de trabalho dos profissionais. RESULTADOS: Para a SB, verificou-se a presença desta em 3 médicos e 5 residentes. Já para a depressão; encontrou-se níveis de mínima (24 indivíduos), leve (4 indivíduos), moderada (4 indivíduos) e grave depressão (1 indivíduo). CONCLUSÃO: Embora obtido baixos valores para a SB e Depressão grave, é relevante destacar que sinais e sintomas iniciais destas patologias estão presentes em muitos profissionais, sendo que a persistência da rotina em que se encontram pode acentuar a aparição de ambas.
SATIŞ GELİŞTİRME ARACI OLARAK İNSERTLER VE TÜKETİCİLERİN SATIN ALMA DAVRANIŞINA ETKİSİ
Authors: ASLAN ÇETİN Filiz
Published: February 2020

Son
zamanlarda perakendecilik sektöründeki işletmelerin bir satış geliştirme aracı
olarak kullandığı insert, ürünler ve hizmetler hakkında tüketicinin bilgi
almasını sağlamada alternatif bir mecra olarak yoğun şekilde kullanılmaya
başlanmıştır. Çalışmada özellikle insertlerin tüketici için ne ifade ettiği ve
insert kullanımının ne ölçüde etkin olduğu belirlenmeye çalışılmıştır. Bu
bağlamda veri toplama yöntemi olarak tüketiciye yüz yüze anket uygulanmıştır.
Kars şehri merkezinde 385 tüketici ile yapılan bu uygulama sonucunda elde
edilen verilere göre; tüketicinin insert içerisinde yer alan bilgileri
önemsediği ve bunun tüketicinin satın alma davranışlarını yönlendirdiği
gözlemlenmiştir. Özellikle insertlerin internet aracılığıyla takip edildiği ve
güçlü markaların ve yüksek indirim oranlarının insertin farkındalığını
artırdığı sonucuna ulaşılmıştır.
Single molecule FISH v1
Authors: Nguyen Thuc , Garren Emma
Published: February 2020

Updated This protocol describes multiround hybrization of directly-conjugated FISH probes for single molecule RNA detection. Thin tissue sections (10-μm) are placed onto silanized coverslips (24x50) that fit onto an ASI imaging chamber. A SecureSeal chamber is placed around the sections, which act as a reaction chamber and imaging chamber.
Clinical score assessment of the degree of respiratory distress in Balb/c mice v1
Authors: Garcia Luciana
Published: February 2020

For the three different protocols at days 7-10 of the allergen challenge (see dx.doi.org/10.17504/protocols.io.bbydips6) the breathing patterns of mice (n=6/group) were recorded on video for the first minute after OVA instillation. The values assigned to increasing signs of respiratory distress were adapted from the respiratory failure clinical score system developed by Wood. This scoring was performed, via a double-blind procedure, by three different physician operators and analyzed by a non-parametric statistical test
Whole-V. cholerae cell lysate SDS-PAGE gel and Western Blot v1
Authors: Baranova Danielle
Published: February 2020

This protocol describes how to do western blots analysis of whole-V. cholerae cell lysates.
Fundamental Solutions for a Class of Multidimensional Elliptic Equations with Several Singular Coefficients
Authors: Ergashev Tuhtasin G.
Published: February 2020

The main result of the present paper is the construction of fundamental solutions for a class of multidimensional elliptic equations with several singular coefficients. These fundamental solutions are directly connected with multiple hypergeometric functions and the decomposition formula is required for their investigation which would express the multivariable hypergeometric function in terms of products of several simpler hypergeometric functions involving fewer variables. In this paper, such a formula is proved instead of a previously existing recurrence formula.The order of singularity and other properties of the fundamental solutions that are necessary for solving boundary value problems for degenerate second-order elliptic equations are determined
Procesos de Elaboración Onírica y Temporalidad Retroactiva en la Obra de Picasso
Authors: Cuevas Javier
Published: February 2020

The aim of this article is to point out the structural coincidence between Pablo Picasso and Sigmund Freud in two matters. Firstly, in the ways of analysing and creating images based on the principles of oniric elaboration such as displacement and condensation. This fact makes it possible to propose a reading of the works created by Picasso after the First World War from a retroactive temporality that would link them not so much to a return to order but to a conception of the image close to the surrealist poetics. Secondly, this article points to another structural coincidence between the two authors that is paradoxical: the construction of modernity in both is produced through recourse to the mythological signifier.
Lista de Revisores
Authors: Team Editorial
Published: February 2020

List of the names of the reviewers of the articles published during the year.
Rabiz: the unintended child of 1960s' urban culture
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Bayadyan H.
Published: February 2020

The article discusses the ideological, social and cultural conditions that made possible the formation and development of "rabiz," a form of urban musical folklore, in the 1960s. Rabiz is described as an undesired result of the Socialist modernization process. It had received certain important aspects from the preserved forms of pre-Soviet urban culture but for some of its key features owes to the soviet cultural policy of the 1930s and the socio-cultural tendencies of the Soviet Armenia of the 1960s and 1970s. Rabiz was a side effect of the industrialization and urbanization of the 60s and was then radically transformed and degraded during the process of post-Soviet deindustrialization.
Polyfunctionality and cultural value of public space: historical and cultural study of an urban square
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Maslikova I. I.
Published: February 2020

The article explores changes in the organization and functioning of public space in cities in the context of sociocultural dynamics – from antiquity to modernity. The sociocultural features of open urban space in ancient Greece and Rome, Renaissance Italy, modern Europe, the USA, Latin America, Ukraine are clarified. The experience of the functioning and management of public space is analyzed on specific examples of world- famous urban squares – Antique agora, roman forum, piazza del Campo in Siena, piazza della Signoria in Florence, piazza San Marco in Venice, Union Square in New York, Latin American squares, Bibikovsky boulevard and University park in old Kyiv, "Maydan" – Independence Square in contemporary Kyiv. Particular attention is being given to transformations of ceremonial, religious, recreational, economic, political, aesthetic and moral functions of open public space. Urban squares are places for official celebrations and religious rituals. They serves as a place of a rest, realization of creative ideas and are a conductor of public communication. Public spaces create opportunities for trade, affect the formation and retention of real estate prices, and are a means of attracting investment and business development in them and adjacent territories. All these provide opportunities for uniting citizens for joint projects and activities, political protests or symbolization of power. It is noted that the cultural value of the modern square is manifested in architectural forms, aesthetics of recreational areas and historical monuments, and is associated with its ability to be a place for the proclamation and implementation of high moral ideals of order, equality, solidarity, freedom, independence, human dignity, the value of moral rights and civic virtues. From the time of antiquity to the present day, the central squares of cities, as a public space, reproduce the aesthetics of the city and become a symbol of spiritual and political power, since temples, municipalities, financial and commercial institutions, theaters, and restaurants are often concentrated in such spaces.
International research-to-practice conference "Symbolic dimensions of visual culture"
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Butsykina Y. O.
Published: February 2020

From October 11 to 12, 2019, the international scientific conference "Symbolic Dimensions of Visual Culture" was held in the city of Lutsk (Ukraine). The event was organized by the Korsaki Museum of Modern Ukrainian Art and the Department of Ethics, Aesthetics and Cultural Studies of Taras Shevchenko National University of Kyiv within the framework of the research theme "Visual Practices: Modes and Strategies of Postmodernism" and the art project "Modern Ukrainian Symbolism", curated by Associate Professor Department S. P. Stoyan. Partners of the conference were the University of Zielona Gora (Poland), the Polish-Ukrainian Center for Humanitarian Studies of the University of Zielona Gora (Poland) and the Public Organization "Art Center Alter Ego".
Analysis of satisfaction with the accessibility and quality of primary health care for patients with pathology of lower limb arteries
Authors: Pogosyan V A , Mikhaylova D O
Published: February 2020

Aim. To study the opinion of the population about satisfaction with the accessibility and quality of primary health care for diseases of the arteries of the lower extremities in institutions of the Sverdlovsk region, as well as to identify problems in the organization of its provision.

Methods. From January to June 2019, an anonymous survey of 384 patients with diseases of the arteries of the lower extremities who applied for a consultative appointment with a cardiovascular surgeon at the clinic of the Sverdlovsk Regional Clinical Hospital No. 1 was carried out. A representative sample was determined by formulae, in which, out of the general population the number of registered cases of arterial disease of the lower limbs in the Sverdlovsk region, was acceptable. The survey involved 301 (78.4%) men and 83 (21.6%) women.

Results. More than 90% of respondents were over 50 years old. More than 35% of respondents expected a referral for a consultation with a specialist later than 1 month away. The accessibility and timeliness of obtaining specialized medical care were influenced by the geographical remoteness from the regional center. The presence of queues in outpatient clinics at the place of residence, the difficulty in obtaining a coupon for an appointment with a doctor, the inaccessibility of free research, as well as the inconvenient work schedule of specialist doctors were the main reasons for not obtaining medical care. When examined in the clinic at the place of residence, more than half of the respondents used their own money. Just over a third of patients (35.2%) thought that the level of medical care has improved over the past decade, 19.5% thought that it had become worse, 16.4% that it had not changed, and 28.9% found it difficult to answer. About half of the respondents (48.8%) were satisfied with the result of the medical care provided, 11.2% were not satisfied, and 40% of the patients found it difficult to answer.

Conclusion. The shortcomings identified in the organization of outpatient care in medical institutions of the Sverdlovsk region indicate the need to improve primary health care for patients with lower limb arterial disease. Such improvements will achieve the goals and objectives of the National Healthcare project through the development of telemedicine technologies and the development of organizational and functional patient routing models, standard operating procedures for examining more patients with cardiovascular pathology by primary care physicians, and their active introduction into public health practice.
Issues of children with disabilities registered as disabled
Authors: Sadykova D I , Solov’ev N A , Kulakova G A , Kurmayeva E A
Published: February 2020

Aim. To analyze the medical and social characteristics of children's disability at the stage of primary medical and social care in the polyclinics of Kazan.

Methods. 185 case reports of development of children with disabilities aged 0 to 17 years were analyzed as well as the questionnaires for their parents and 96 case reports of healthy peers of the same age group based on the data from children polyclinics N. 9 and 7 of Kazan. Relative values were calculated to process the results.

Results. The conducted analysis revealed that children with the status of disabled persons were more often born in aged and young mothers, with pathological pregnancy and first birth. In the structure of disability causes, psychiatric disorders and nervous system diseases are prevailing. Disabled children acquire acute diseases more often than their healthy peers that causes additional expanses for the family, including those due to the care for acutely ill child, and requires additional provision with medications. Individual lessons in the rehabilitation of a child with disabilities require additional financial investments from the family budget. We revealed the need for implementation of educational courses for the parents of disabled children due to that every second family did not have specific knowledge and skills of care and rehabilitation, when a child had functional limitations found.

Conclusion. Families with children with disabilities in the status of a disabled child need additional assistance in solving medical and social problems.
Tactics of primary care physician in the management of patients with asthma in accordance with the latest changes in international and national guidelines
Authors: Pokhaznikova Marina A.
Published: February 2020

The article addresses to changes in the management of patients with bronchial asthma in accordance with international and national recommendations of 2019. The new management strategy for patients with mild asthma, the rejection of short-acting 2-agonist (SABA) reliever medication monotherapy in favor of an anti-inflammatory bronchodilator drug will improve disease control, patient compliance, reduce the risk of severe exacerbations and death. The use of the algorithm for diagnosing and management asthma by primary care physicians, developed by experts of the Russian Respiratory Society and the Russian Association of Allergologists and Clinical Immunologists, will reduce the time for diagnosing asthma, timely and correctly prescribe anti-inflammatory therapy and control the course of the disease.
Survey and Continuous GNSS in the Vicinity of the July 2019 Ridgecrest Earthquakes
Authors: Floyd Michael , Funning Gareth , Fialko Yuri , Terry Rachel , Herring Thomas
Published: February 2020

The Mw 6.4 and Mw 7.1 Ridgecrest, California, earthquakes of July 2019 occurred within 34 hr of each other on conjugate strike-slip faults in the Mojave Desert, just north of the central Garlock fault. Here, we present the results of a survey of 18 Global Navigation Satellite Systems (GNSS) sites conducted in the immediate aftermath of the earthquakes, including five sites that recorded the motion of the second earthquake after having been set up immediately following the first, as well as processed results from continuous GNSS sites throughout the region. Our field work in response to the earthquakes provides additional constraints on the ground displacement due to both earthquakes, complementing data from a spatially sparser network of continuously recording GNSS sites in the area, as well as temporally sparser Interferometric Synthetic Aperture Radar data that were able to capture a combined deformation signal from the two earthquakes.
Formação em Pedagogia: Habilidades e Competências Desenvolvidas na Formação Inicial
Authors: Pasetto Luciane Zamberlan , Boer Noemi
Published: February 2020

Nesse artigo, têm-se como objetivo analisar aspectos relativos à formação inicial e continuada, bem como habilidades e competências desenvolvidas na trajetória profissional de oito professores dos Anos Iniciais do Ensino Fundamental de Santa Maria, RS. Busca-se também elucidar a reflexão crítica em relação à formação e atuação docente neste nível de ensino. O aporte teórico está fundamentado, basicamente, em Cavaco, Freire, Marcelo Garcia, Imbernón, Nóvoa e Pimenta. A análise, de natureza qualitativa, examina narrativas temáticas, coletadas em entrevista com os participantes da pesquisa.  Para esta finalidade procurou-se nos autores citados, sustentação teórica para a interpretação das narrativas selecionadas. Quanto às habilidades e competências adquiridas no curso de Pedagogia, o estudo mostra a importância dos estágios curriculares e dos projetos de intervenção na correlação teoria e prática, autonomia do professor e o saber planejar. Com relação à formação inicial e continuada dos participantes, as narrativas corroboram o que dizem os autores que fundamentam este estudo de que ambas executam uma interlocução constante, tendo em vista que a formação ocorre ao longo da vida. Portanto, as narrativas da trajetória pessoal de professores se constituem em um valioso material de análise pois, contemplam aspectos importantes da docência e de sua formação.   Palavras-chave: Aprendizagem. Aprendizagem Docente. Professores e Formação Continuada. AbstractIn this article, we aim to analyze aspects related to initial and continuing formation, as well as skills and competencies developed in the professional trajectory of eight teachers of the initial years of elementary School of Santa Maria, RS. It also seeks to elucilist the critical reflection in relation to the education and teaching performance at this level of education. The theoretical contribution is basically based on Cavaco, Freire, Marcelo Garcia, Imbernón, Nóvoa  and Pimenta. The analysis, of a qualitative nature, examines thematic narratives, collected in an interview with the research participants.  For this purpose, we searched for the authors cited, theoretical support for the interpretation of the selected narratives. As for the skills and competences acquired in the pedagogy course, the study shows the importance of the curricular internships and intervention projects in the theory and practice correlation, teacher autonomy and the knowledge to plan. In relation to the initial and continuing formation of the participants, the narratives corroborate what the authors say that support this study that both perform a constant interlocution, considering that the formation takes place throughout life. Therefore, the narratives of the personal trajectory of teachers constitute a valuable material of analysis because they contemplate important aspects of teaching and their formation.  Keywords: Learning Teacher Learning. Teachers and Continuing Education.
A Avaliação como Fio Condutor da Prática Pedagógica
Authors: Pedrochi Junior Osmar , Buriasco Regina Luzia Corio de
Published: February 2020

A atual perspectiva de avaliação formativa, se preocupa com a formação dos alunos mais do que em dar notas, atuando de forma contínua, preocupando-se com todos os aspectos e todos os envolvidos no processo de ensino e aprendizagem, faz da avaliação uma peça chave dentro desse processo, superando a suas funções mais conhecidas de verificar e certificar por meio de notas ou conceitos. Tem-se o objetivo de apresentar uma perspectiva de avaliação que pode conduzir as ações pedagógicas de professores e alunos. Para isso, buscou-se na literatura o sentido da avaliação formativa, por meio de uma pesquisa especulativa baseada em Martineau, Simard e Gauthier (2001) e Van Der Maren (1996), trata-se do conceito de avaliação formativa desde a sua gênese até o que atualmente é discutido na literatura. Por fim, apresenta uma perspectiva de avaliação que tem a função de conduzir todas as práticas em sala de aula. Palavras-chave: Ensino. Avaliação. Avaliação Formativa.AbstractThe perspective of formative assessment, which is concerned with the formation of students rather than grading, acting continuously, worrying about all aspects and everyone involved in the teaching and learning process, makes evaluation a piece key within this process, surpassing its most well-known functions of verifying and certifying through notes or concepts. This article aims to present an evaluation perspective that can lead the pedagogical actions of teachers and students. For this, we sought in the literature the meaning of formative evaluation, through a speculative research based on Martineau, Simard and Gauthier (2001) and Van Der Maren (1996), this article deals with the concept of formative evaluation since its inception. even what is currently discussed in the literature. Finally, it presents an evaluation perspective that has the function of conducting all classroom practices. Keywords: Learn. Assessment . Formative Assessment.