bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF MUNICIPAL GOVERNMENT IN THE REGULATION
OF THE PRICING OF THE VOLYN IN THE EARLY XX CENTURY
Authors: Savina Natalia , Tsetsyk Yaroslav
Published: September 2017

The article describes the features of the regulation on pricing policy of Volyn in the
period of the early twentieth century. The role of local authorities in this process has been
investigated. Found out that the bodies of municipal government during World War I tried
to adjust the price of food and essential goods, but given the realities of the war, they were
forced to their povyshat. An important element in this work city councils in Volyn was that
they managed to avoid sharp jumps in prices for main groups of goods, to a certain extent
weakened the social tension in the border areas. While the price review mechanism was
used. The reasons for the revision of prices were handling the merchants with offers them
to reconsider. So, these issues were dealt with at the local level and in different places the
price could at one and the same product differ.
SUBSTANTIATION OF EVALUATION CRITERIA FOR OVERALL
FUNCTIONING EFFICIENCY OF UKRAINIAN DANUBE RICE IRRIGATION SYSTEMS
Authors: Rokochynskyy Anatoly , Mendus Sergey , Basil Turchenyuk
Published: September 2017

The paper presents the results of studies the efficiency of the Danube rice irrigation
systems south of Ukraine on the basis of appropriate analysis of productivity leading rice
rotation culture - the culture of rice.
Substantiated a set of indicators covering different aspects of the complex process of
formation of a crop of rice crop, with the aim of improving and optimizing the management
of rice irrigation system in compliance with the modern ecological and economic
requirements.
THE METHODICAL APPROACH OF AUDITING THE LOGISTICS SYSTEM IN THE
AGRICULTURAL ENTERPRISES ON PRODUCTION OF DAIRY CATTLE
Authors: Ulyanchenko Aleksandr , Prozorov Roman
Published: September 2017

The technique of the logistics audit in the agricultural enterprise on production of
dairy cattle, which provides the definition of the state of logistics, by peer review. Also
defined are not developed component logistics system and suggested a further approach
its assessment and identified the main directions of its improvement.
THE FORMATION OF FINANCIAL ACCOUNTING
OF BUDGETARY INSTITUTIONS IN THE BUDGET ACCOUNTING MODERNIZATION
Authors: Doroshenko Olena
Published: September 2017

The article devoted to the issues of formation of the subsystem of financial accounting
in budgetary institutions of Ukraine in the new contemporary conditions modernization of
public sector management. The author examines the preconditions for budget accounting
modernization in the context of to approaching to international standards.
MACROECONOMIC REGULARITIES AND THE REGULATION INSTRUMENTS
OF LABOR MARKET IN UKRAINE
Authors: Urchik Galuna
Published: September 2017

In the article the macroeconomic patterns of functioning national labor market in conditions
of instability. The features of the mutual influence of macroeconomic trends and
the labor market. The necessity of regulating the national labor market in times of economic
instability through economic instruments. Investigated the current mechanism of
regulation of the labor market of Ukraine in macroeconomic leverage. The directions of
its improvement in order to reduce tension in the labor market.
SCIENTIFIC AND METHODOLOGICAL APPROACHES TO THE
ASSESSMENT OF INEQUALITY OF ORGANIZATIONAL AND
TECHNOLOGICAL ENVIRONMENT IN THE FIELD OF IRRIGATION
AGRICULTURE
Authors: Kostiukevich Ruslan , Kostiukevich Alina
Published: September 2017

Given the peculiarities of the organizational and economic relations in the field of irrigation
agriculture, it is established that depending on the structure of the integration of
agricultural producers may experience unequal conditions for economic and organizational
interaction with the water management organization within a reclamation system.
The developed model of the mechanism of state regulation of organizational and economic
relations based on the alignment of economic conditions on reclaimed land. Established
that government regulation level the competitive conditions depend on economic potential
of agricultural production on reclaimed lands, as well as the importance of the social and
environmental consequences of termination in case of impossibility to form a stable system
of management.
MONITORING AS PART OF PROPERTY RELATION TRANSFORMATION
MECHANISM IN THE FIELD OF RECLAMATION SERVICES
Authors: Mandziuk Olha
Published: September 2017

The trends in the development of property relations transformation in the sphere reclamation
services in Ukraine are analyzed in the article. Key problems in this area are
detected. The mechanism of property relations transformation in reclamation services is
improved. The process of monitoring of relations transformation in reclamation services
is proposed. The main groups of indicators for monitoring are identifies.
LOCAL GOVERNMENTS – AS THE BASIS OF FORMATION OF BUDGET
POTENTIAL OF THE REGION
Authors: Melnyk Leonid , Duma Viktoriya
Published: September 2017

The effectiveness of the budget system of Ukraine is largely determined by the availability
of financial resources in the region. The budget system of the region is a leader in determining
its financial condition and characterized by certain parameters that can be expressed
in terms of fiscal capacity.
The aim of the article is the generalization of theoretical approaches to the essence of
the budget potential of the region, to develop a model of its formation and determine the
factors that influence the potential increase in the budget.
MODERN TECHNOLOGIES OF DATAWARE OF REFLECTION MANAGEMENT
COMPETITIVENESS OF ENTERPRISE
Authors: Malchyk Mariana
Published: September 2017

In this work examined the necessity to use of modern technologies of dataware of
enterprise during reflection management by his competition possibility. It is explained,
that at the construction of models of dataware of reflection management the
competitiveness of enterprises the use methodology of IDEF0 is expedient, that improve
quality and depth of work, to systematize information, decrease the number of errors.
SOCIAL CAPITAL AND PLACE OF CHARITABLE ASSISTANCE EXPENSES IN IT: OVERVIEW AND ACCOUNTING IMPLEMENTATION
Authors: Zhygley Irina , Syvak Olena
Published: September 2017

In the article author analyzes the theoretical content of the concept of social capital, taking into account the economic point of view. Furthermore, the author defines the place of charitable assistance expenses in the social capital, as well as the peculiarities of reflection of these expenses in the accounting.
AN ELECTRONIC CONTROL – THE TOOL OF DEMOCRATIZATION OF STATE ADMINISTRATION
Authors: Romanenko Evgeniy
Published: September 2017

In the paper carried out the analysis of e-government as a means of interactive and communicative interaction of public authorities and the public allowed to identify it as a self-organizational tools for effective public-management decisions, to ensure transparency mechanisms for monitoring their implementation. Analyzed the history of creation and international documents that contain recommendations, the requirements for States parties that intend to build or develop at an effective information society. It is shown that the rate of introduction of E-governance in Ukraine is considerably lagging behind the leading countries of the world.
THE GLOBAL COOPERATION IN BIODIVERSITY CONSERVATION
Authors: Yakymchuk Alina
Published: September 2017

In this paper the prospects and opportunities of improving of conservation at the
global level have been studied. The sources and amounts of financing of natural protected
areas have been analyzed. The possibility of increasing efficiently use financial resources
has been considered. The categorical apparatus of the concept of "biological diversity"
has been improved. The author's own concept of biodiversity has been given. It is shown
that the current system of conservation is not entirely effective and should be adjusted
globally. The mechanisms for intensifying global cooperation in the field of biodiversity
conservation have been ordered. The main directions of solving the problem of
preservation of the gene pool and cooperation in this sphere have been ordered. An
important task has economic incentives for the maintenance of the natural state of natural
protected areas.
THE CLASSICS OF SOCIOLOGY ABOUT THE ELITES CIRCULATION IN SOCIETY:
A MODERN INTERPRETATION
Authors: Balabayeva Zinaida
Published: September 2017

This article discusses some of the classic tenets of the theory change (circulation) elites
V. Pareto and other representatives of the theory of elites (U.Moska, R.Mihels), which
allow to draw parallels with the present to understand the peculiarities of the political
process today. Also presents modern theory of elites, which allow showing specificity of
the process change of elites in modern post-Soviet conditions.
Crack resistance of tool steels
corresponding with the chemical
composition of their matrices
Authors: Pacyna J.
Published: September 2017

Purpose: of the presented investigations was showing that the crack resistance of
tool steels depends on their hardenability and phase transformations occurring in the
quenched matrix at tempering. The chemical composition of austenite decides on the steel
hardenability while phase transformations after tempering can be influenced (apart from the
chemical composition) by the heating method.
Design/methodology/approach: of investigations was based on the analysis of
dilatograms and the achieved aim was to obtain the hard tool steel (app. 500 HV30) for hot
works. Samples of a diameter of 10 mm (without a notch) made of this steel were not broken
by the Charpy impact test of energy of 30 kGm.
Findings: of these investigations are practical. Grain boundaries of prior austenite should
be protected against secondary precipitates, which constitute natural nuclei of diffusive
structures. It is also possible to control phase transformations at tempering.
Research limitations/implications: constitute the availability of the adequate equipment
for investigating the kinetics of phase transformations of undercooled austenite and the
kinetics of phase transformations after tempering.
Practical implications: for the industry are such that the proposed tool steels of a high
crack resistance contain molybdenum and nickel. Thus, these steels are very expensive.
Originality/value: of these investigations was confirmed in the industrial practice.
Fatigue crack growth resistance
of welded joints simulating the
weld-repaired railway wheels metal
Authors: Ostash O.P. , Kulyk V.V. , Poznyakov V.D. , Haivorons’kyi O.A. , Markashova L.I. , Vira V.V. , Duriagina Z.A. , Tepla T.L.
Published: September 2017

Purpose: The aim of the paper is to study the structure and fatigue crack growth resistance
characteristics of weld metal (WM), and heat affected zone (HAZ) under cyclic loadings for
the development of railway wheels weld-repairing technology.
Design/methodology/approach: WM and HAZ of the welded joint were investigated.
The welded joint of 65G steel (0.65 mass.% C; 0.19 Si; 0,91 Mn), which is a model material
for high-strength railway wheels, was received by welding Sv-08HM wire per linear welding
energy of 10 kJ/cm. Regimes of welding were selected so that the cooling rate of the metal
in the temperature range 500-600°C was 5°C/s. As a result, the bainite structure in WM and
bainite-martensite one in HAZ are formed. To eliminate the residual stresses generated after
the weld cooling, heat treatment was proposed: holding at 100°C for 2 hour after cooling
under temperature below then that at the beginning of martensite transformation. Fracture
resistance under cyclic loading was estimated by fatigue crack growth rates diagrams
(da/dN vs. ΔK) according to standard method for compact tension samples testing. The
microstructure and fracture surface were investigated using an optical, and electronic
scanning and transmission microscope.
Findings: Microstructure parameters and fatigue crack growth resistance characteristics of
WM and HAZ after the proposed heat treatment, and also residual stresses of the second
kind and local strains in the bulk of bainite and martensite are obtained.
Research limitations/implications: Investigations were conducted on samples that
simulate the structure and properties of real renovated railway wheels made of steel with
high content (0.65%) of carbon.
Practical implications: Service durability and safety of weld-repaired railway wheels
under high service loadings is increased.
Originality/value: HAZ is the most dangerous zone in terms of fatigue cracks initiation and
propagation in elements repaired by surfacing method. The positive result on the proposed
heat treatment influence is received since the fatigue crack growth resistance characteristics
of HAZ metal with bainite-martensite structure raise to the level of weld metal.
As crises do petróleo e a geoestratégia dos Estados Unidos para o Golfo Pérsico entre 1945 e 1980
Authors: Lemos José Késsio , Pacheco Cristina Carvalho
Published: September 2017

Em 1945, um relatório do Departamento de Estado americano afirmou que o controle do petróleo do Oriente Médio seria uma fonte prodigiosa de poder político e econômico. O relatório foi uma resposta às tensões políticas do final da guerra, e também ao rápido crescimento no consumo dentro dos EUA, que elevou a crença estadunidense de que a dependência energética do petróleo estrangeiro se tornaria inevitável. Esta percepção alertou a Casa Branca sobre a necessidade de proteger as futuras importações de petróleo do país. A estratégia escolhida consistiu no estabelecimento de um protetorado americano na Arábia Saudita e da presença militar permanente no Golfo Pérsico. Estimulado por esse cenário, o presente artigo consiste em oferecer um panorama acerca da geoestratégia dos EUA para o Golfo Pérsico entre 1945 e 1980, explorando a interseção entre a energia, a segurança e a política internacional. O objetivo será analisar a histórica relação entre o petróleo, a política externa estadunidense e a configuração geopolítica do Golfo Pérsico, destacando como esta relação acabou colaborando para o desenvolvimento de um cenário marcado por disputas, guerras e instabilidade
A Tríplice Fronteira Sul sob a ótica do terrorismo: uma análise da legislação antiterrorismo da Argentina, Brasil e Paraguai
Authors: Aita Edson
Published: September 2017

O artigo busca apresentar a Tríplice Fronteira Sul (TFS) sob a ótica do terrorismo e, sendo esta uma região sob suspeita de apoiar a logística das ações terroristas ou mesmo potencial palco de atentados, analisar em que medida a legislação antiterrorista da Argentina, do Brasil e do Paraguai está adequada para lidar com este fenômeno global. Para tal, foi realizada uma pesquisa bibliográfica e documental, sendo subsidiado por legislações e produção acadêmica sobre o tema. Ainda que o governo dos países da TFS se esforcem para contradizer toda a suspeição que envolve a região e que nada de concreto relacionado ao terrorismo tenha sido comprovado, a TFS trouxe para dentro da América do Sul, mesmo que retoricamente, o jihadismo, juntamente com toda a problemática que o envolve, como o medo, a incerteza e a pressão de autoridades internacionais por adoção de medidas que busquem prevenir e combater esta ameaça. Assim, as legislações dos países em estudo parecem estar alinhadas com os principais pontos das convenções internacionais, e, em que pese algumas imperfeições, os legisladores preocuparam-se em tipificar o ato terrorista, a atuação de grupos terroristas e o financiamento do terrorismo, dando maior amparo ao Estado.
Preparation of Magnetic Multi-Walled Carbon Nanotubes to Adsorb Sodium Dodecyl Sulfate (SDS)
Authors: Rahmani Zahra , Samadi Mohammad Taghi
Published: September 2017

Surfactants are one of the main groups of pollutants released into aqueous solutions due to human activities and their harmful effects have been proven on human. In this study, first, magnetic multi-walled carbon nanotubes (MMWCNTs) were synthesized and then, the effects of operating parameters such as surfactant concentration, adsorbent dosage, and pH values were analyzed on the adsorption process. MMWCNTs were characterized by means of X-ray diffraction (XRD) analysis and fourier transform infrared spectroscopy (FTIR). The optimal adsorption conditions were achieved at initial pH = 4.6, adsorbent concentration = 0.5 g/L, and initial SDS concentration = 15 mg/L. In addition, the equilibrium of sorption reached after 120 min and the maximum capacity of SDS for monolayer coverage was found to be 61 mg/g at 25°C. Kinetic studies were performed under optimal conditions and the sorption kinetics was described using the pseudo-second-order kinetic model. The experimental data were studied using Freundlich, Langmuir, and Sips models. Finally, the experimental data were fitted reasonably by Langmuir isotherm. The results demonstrated that MMWCNTs with respect to their high adsorption capacity, relatively low equilibrium time, and capability to be separated from aqueous solutions (after adsorption) could be applied to wastewater treatment.
Domingo tem Abertura: um programa de televisão na cobertura da abertura política no Brasil
Authors: Maia Paulo Roberto de Azevedo
Published: September 2017

O artigo analisa a constituição do programa Abertura, veiculado pela Rede Tupi, entre fevereiro de 1979 até maio de 1980. Trata-se de uma experiência de articulação política na TV ao discutir a abertura no exato momento em que esse processo ganhava maior espaço no início do governo do general João Baptista Figueiredo. O formato de revista, com uma equipe formada por Villas Bôas Corrêa, Sérgio Cabral, Fausto Wolf, Roberto D’avila, Ziraldo, Glauber Rocha e outros, inovou na linguagem ao propor uma reflexão jornalística audiovisual sobre as possibilidades do fim do regime civil-militar. Muitos dos apresentadores estavam ligados ao pensamento de esquerda e discutiram questões importantes como anistia, exílio, censura, pluripartidarismo e eleições diretas para todos os níveis, contribuindo para o processo de luta democrática. A leitura do programa realizada pela imprensa escrita da época, e a constituição de uma autoimagem relacionada ao pioneirismo da iniciativa de lutar pela redemocratização do país na televisão conduzem a uma visão dicotômica, na qual se confrontaram a crítica de conteúdo e forma e a força do discurso do Abertura na tentativa de se firmar na memória política da mídia brasileira Palavras-chave: Imprensa e Politica. Telejornalismo. Ditadura e Ditadores.
A transição democrática brasileira (1974-1989) pelas lentes de João Batista de Andrade
Authors: Oliveira Alcilene Cavalcante
Published: September 2017

Este artigo aborda a relação entre memória e mídia, a partir do longa-metragem, de ficção, A Próxima Vítima (1983), de João Batista de Andrade, partindo da ideia de que um artefato cultural é um suporte de memória. Se um filme, mesmo de modo ficcional, encena aspectos do presente do período no qual é realizado, constitui registros que lhe conferem tal lugar de memória. O filme de Andrade, concebido no início dos anos 1980 e herdeiro da trajetória profissional do diretor, tanto no cinema quanto na televisão, entra nos embates de memória, como testemunho do período de transição democrática no Brasil (1974-1989), seja por sua datação, seja pelo que artificiosamente constrói. No texto, situamos, incialmente, questões que sobressaem na chave memória e mídia; em seguida, passamos pela cinematografia do cineasta, no que se conecta ao filme em questão; a chegada é o filme como memória da transição. Palavras-chave: Cinema e História. Memória. Brasil-História- 1974-1989.
“O que era simples imprensa virou mídia”: como o MST divulgou os meios de comunicação de massa
Authors: Perli Fernando
Published: September 2017

Este artigo analisa a construção de uma agenda política do Movimento dos Trabalhadores Rurais Sem Terra (MST) que tratou do lugar ocupado pelos meios de comunicação de massa nas reivindicações de movimentos sociais nas décadas de 1980 e 1990. Os impressos estudados foram o Boletim Sem Terra, o Jornal Sem Terra e a Revista Sem Terra, materiais de divulgação que constituíram um campo de comunicação em defesa de projetos políticos afinados à reforma agrária no Brasil. As produções, distribuições e usos dos impressos para capacitar quadros e divulgar a organização do MST tiveram o apoio de entidades civis, intelectuais, jornalistas, sindicalistas e lideranças sem-terra. Dentre uma variedade de temas publicados, o presente texto delimita editoriais, reportagens e artigos que expressaram posições da direção nacional do MST diante do silenciamento ou de coberturas dadas por empresas de televisão, rádio e jornais de ampla circulação às mobilizações de trabalhadores rurais sem-terra. Palavras-chave: Movimento dos Trabalhadores Rurais Sem Terra. Meios de Comunicação de Massa. Impressos.
Visualidades opacas para el dolor: (entre) viajes, ruinas y memorias. A propósito de Cándido López. Los campos de batalla (José Luis García, 2005)
Authors: Aimaretti Maria
Published: September 2017

El presente artículo se propone como una reflexión ensayística respecto del trabajo de memoria que, a través del juego de tensiones y resonancias entre imagen pictórica e imagen cinematográfica, propone el film de José Luis García Cándido López. Los campos de batalla (2005). Nos interesa observar la dinámica no siempre armónica entre las diferentes capas de relatos y voces que, superpuestas, configuran un frondoso mapa-en-proceso que relee cierto episodio del pasado histórico, uno especialmente desdibujado de las narraciones hegemónicas: la guerra de la Triple Alianza contra Paraguay (1865-1870). A propósito de los dilemas de representación del ejercicio de la fuerza y los recuerdos/olvidos del horror, nos detendremos tanto en la lectura que el film realiza sobre su principal intertexto –los cuadros de Cándido López- como en la propia puesta en escena del documental. Palabras clave: Memoria Visual. Guerra. Candido López. Viaje. Monumento.
Paisagem de cacos e dores revoltadas: as marginalias da ditadura em livros de uma biblioteca universitária
Authors: FARIA Daniel
Published: September 2017

ResumoEsse artigo resulta da formação de uma coleção de marginalias encontradas em livros relacionados à ditadura, presentes na Biblioteca Central da Universidade de Brasília. Essas marginalias (anotações, intervenções gráficas, interferências no texto e nos elementos para-textuais), mostraram-se particulares por seu sentido político, tanto no que se refere ao conteúdo quanto à circulação de opiniões e críticas que elas configuraram. Elas são analisadas, aqui, diante do pano de fundo das questões relativas à memória da ditadura militar, às políticas da ditadura sobre as mídias, em particular a circulação dos impressos e, em especial, a biblioteca como lugar de memória. Palavras-chave: Biblioteca Universitária – Brasília, DF. Brasil - História - 1964-1985. Ditadura e Ditadores. Escrita.
Teoria da História – a escrita, o lugar do morto e do assombro: diálogos com Michel de Certeau
Authors: Alonso Leandro Seawright
Published: September 2017

Pretende-se problematizar a escrita da História com base em uma parte da teoria do historiador francês Michel de Certeau. Para tanto, abordam-se outros autores, de lugares acadêmicos distintos, por meio dos quais se promovem diálogos epistemológicos com Certeau. A análise teórica que se segue busca dialogar com um conceito de escrita que considera a História como uma “escrita de mortos”. Expressões como escrita, narrativa, representação, morte e assombro são consideradas com o fito na “problematização” que se apresenta. De uma parte da obra de Michel de Certeau, almeja-se uma polissemia em contato com diferentes historiadores apresentados no desenvolvimento do texto; faz-se alusão a um episódio da peça shakespeariana “Hamlet” e às noções psicanalíticas apresentadas por Michel de Certeau com fulcro em textos de Sigmund Freud e Jacques Lacan. Palavras-chave: Teoria da História. Escrita da História. História.
Acessibilidade documental e autoridade compartilhada: pela construção de uma história pública
Authors: Werle Bibiana
Published: September 2017

Focalizando a temática mais ampla acerca de abusos do esquecimento provocados por narrativas oficiais locais e, consequentemente, sobre a implicação disso em relação ao ofício dos historiadores e historiadoras, este artigo perscruta caminhos que reflitam sobre a construção de narrativas históricas que levem em conta a participação cidadã no seu processo de realização e divulgação. Para isso, o texto está dividido em duas partes. Inicialmente, a informação sobre a exígua quantidade de arquivos públicos municipais no Brasil é objeto de apreciação levando em conta tanto a legislação nacional que advoga pela acessibilidade, proteção e gestão pública documental, como as dificuldades e carências em relação à institucionalização e à manutenção de arquivos municipais, e também as orientações normativas e ações desenvolvidas pelo CONARQ no intuito de fomentar a implementação destas instituições. Num segundo momento, a discussão em torno dos esquecimentos e ocultamentos propiciados por narrativas oficiais locais é abordada em relação a um específico município do estado do Rio Grande do Sul, possibilitando a reflexão acerca da construção de narrativas locais que observem o princípio de uma autoridade compartilhada. Desenha-se, assim, uma análise que leva em consideração uma história pública em que historiadoras e historiadores contem com a atuação colaborativa de agentes locais que possam problematizar e recobrar vestígios sobre o passado obliterados por mecanismos públicos que, no tempo presente, intentam agir como vetores de uma determinada memória. Palavras-chave: Arquivos Municipais. História Local. Documentos Públicos.
Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish
Authors: Ishikawa Tokiro , Kashima Makoto , Nagano Atsushi J , Ishikawa-Fujiwara Tomoko , Kamei Yasuhiro , Todo Takeshi , Mori Kazutoshi
Published: September 2017

When activated by the accumulation of unfolded proteins in the endoplasmic reticulum, metazoan IRE1, the most evolutionarily conserved unfolded protein response (UPR) transducer, initiates unconventional splicing of XBP1 mRNA. Unspliced and spliced mRNA are translated to produce pXBP1(U) and pXBP1(S), respectively. pXBP1(S) functions as a potent transcription factor, whereas pXBP1(U) targets pXBP1(S) to degradation. In addition, activated IRE1 transmits two signaling outputs independent of XBP1, namely activation of the JNK pathway, which is initiated by binding of the adaptor TRAF2 to phosphorylated IRE1, and regulated IRE1-dependent decay (RIDD) of various mRNAs in a relatively nonspecific manner. Here, we conducted comprehensive and systematic genetic analyses of the IRE1-XBP1 branch of the UPR using medaka fish and found that the defects observed in XBP1-knockout or IRE1-knockout medaka were fully rescued by constitutive expression of pXBP1(S). Thus, the JNK and RIDD pathways are not required for the normal growth and development of medaka. The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6
Authors: Bak Rasmus O , Dever Daniel P , Reinisch Andreas , Cruz Hernandez David , Majeti Ravindra , Porteus Matthew H
Published: September 2017

Precise and efficient manipulation of genes is crucial for understanding the molecular mechanisms that govern human hematopoiesis and for developing novel therapies for diseases of the blood and immune system. Current methods do not enable precise engineering of complex genotypes that can be easily tracked in a mixed population of cells. We describe a method to multiplex homologous recombination (HR) in human hematopoietic stem and progenitor cells and primary human T cells by combining rAAV6 donor delivery and the CRISPR/Cas9 system delivered as ribonucleoproteins (RNPs). In addition, the use of reporter genes allows FACS-purification and tracking of cells that have had multiple alleles or loci modified by HR. We believe this method will enable broad applications not only to the study of human hematopoietic gene function and networks, but also to perform sophisticated synthetic biology to develop innovative engineered stem cell-based therapeutics.
Molecular determinants of permeation in a fluoride-specific ion channel
Authors: Last Nicholas B , Sun Senmiao , Pham Minh C , Miller Christopher
Published: September 2017

Fluoride ion channels of the Fluc family combat toxicity arising from accumulation of environmental F-. Although crystal structures are known, the densely packed pore region has precluded delineation of the ion pathway. Here we chart out the Fluc pore and characterize its chemical requirements for transport. A ladder of H-bond donating residues creates a ‘polar track’ demarking the ion-conduction pathway. Surprisingly, while track polarity is well conserved, polarity is nonetheless functionally dispensable at several positions. A threonine at one end of the pore engages in vital interactions through its β-branched methyl group. Two critical central phenylalanines that directly coordinate F- through a quadrupolar-ion interaction cannot be functionally substituted by aromatic, non-polar, or polar sidechains. The only functional replacement is methionine, which coordinates F- through its partially positive γ-methylene in mimicry of phenylalanine’s quadrupolar interaction. These results demonstrate the unusual chemical requirements for selectively transporting the strongly H-bonding F- anion.
Morphology‐Control Strategy of the Superhydrophobic Poly(Methyl Methacrylate) Surface for Efficient Bubble Adhesion and Wastewater Remediation
Authors: Zhang Chunhui , Cao Moyuan , Ma Hongyu , Yu Cunlong , Li Kan , Yu Cunming , Jiang Lei
Published: September 2017

As one common form of gas existing in aqueous environment, gas bubbles have attracted considerable worldwide attention, owing to their promising applications in industrial production and daily life, such as pressure sensors, the recovery of valuable minerals from ores, aeration process, and water treatment. Usually, the behaviors of gas bubbles in aqueous environment are mainly dominated by buoyancy force. It drives the gas bubbles out of aqueous medium rapidly, which is unfavorable in various processes, especially in wastewater treatment. In this paper, various types of superhydrophobic poly(methyl methacrylate) (PMMA) sheets are facilely fabricated, such as five‐pointed star, triangle, circular, and ellipse. Compared with other shapes of superhydrophobic PMMA sheets, the prepared superhydrophobic PMMA circular sheet is capable of efficiently adhering gas bubbles and subsequently elongating their retention time in an aqueous environment. Furthermore, superhydrophobic PMMA circular sheet arrays are prepared, which can greatly improve the degradation efficiency of methyl blue by ozone (O3). The investigations indicate that the present approach will find wild applications in bubble‐related fields and provide people with inspirations to develop efficient methods to manipulate gas bubbles in aqueous environment.
Rechargeable Solid‐State Li–Air and Li–S Batteries: Materials, Construction, and Challenges
Authors: Liu Yijie , He Ping , Zhou Haoshen
Published: September 2017

Nonaqueous Li–air and Li–S batteries are attracting considerable interest because of their outstanding theoretical capacities and energy densities. However, despite the substantial progress in their development, safety remains an issue because of the flammability of their organic electrolytes. Moreover, the electrolyte volatilization of Li–air batteries and “shuttle effect” in Li–S batteries seriously hinder their development. The use of solid‐state Li–air and Li–S batteries is one of the best solutions. Nevertheless, many challenges remain in solid electrolytes, electrodes, and interfaces. In this review, a comprehensive discussion on the development of solid‐state Li–air and Li–S batteries is provided. The discussion begins with introduction of the progress in solid electrolytes, including their ionic conductivities and chemical stabilities. It then moves on to the cathodes of both batteries and the interface between electrolytes and electrodes. The reaction process inside the cathode is also presented. Suggestions for the optimization of composite cathodes and modification of the electrode–electrolyte interface are provided in the end. Intensive effort is required for the development of solid‐state Li–air and Li–S batteries in the future.
Mutual compensation of the effects of religious and ethnic homogamy on reproduction
Authors: Huber Susanne , Fieder Martin
Published: September 2017

Objectives

Homogamy, mating based on similarity, has been demonstrated for a great variety of traits such as age, education, religion, and physical and psychological traits. Recently, pro‐fertile effects of religious as well as educational homogamy have been reported. We investigate whether ethnic homogamy also has a pro‐fertile effect and whether ethnic and religious homogamy interact in their putative effects on reproduction (in terms of average number of offspring).

Methods

We analyzed the association between ethnic as well as religious homogamy and woman's average number of offspring based on census data from ten countries provided by IPUMS international, encompassing a total of 1,485,433 married women aged 46‐60 years (who have thus completed or almost completed reproduction) and their spouses.

Results

We find a clear pro‐fertile but nonadditive effect of both ethnic and religious homogamy, which is most pronounced in the case of double homogamy. Our results further indicate that homogamy for one trait may compensate for heterogamy of the other, albeit countries differ regarding which trait compensates for the other.

Conclusions

We suggest that the interaction between ethnic homogamy, religious homogamy, and reproduction provides an interesting example for gene‐culture co‐evolution.
Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining
Authors: Kaweewan Issara , Komaki Hisayuki , Hemmi Hikaru , Kodani Shinya
Published: September 2017

A new antibacterial cyclic peptide, named curacomycin (1), and its analogue dechlorocuracomycin (2) were isolated from Streptomyces curacoi (NBRC 12761T) and Streptomyces noursei (NBRC 15452T), respectively, by using genome mining. The chemical structures of these two peptides were determined by using a combination of MS (ESI) and NMR spectroscopy. The structure of compound 1 was determined to be a cyclic peptide that consisted of six amino acids, including: valine (Val), leucine (Leu), isoleucine (Ile), ornithine (Orn), β‐hydroxyasparagine (OHAsn), and 5‐chlorotryptophan (ClTrp). The NMR data of compound 2 were very similar to that of compound 1, which indicated that the structure of compound 2 was a dechlorinated analogue of compound 1. A comparison of the antimicrobial activities of these two peptides indicated that the presence of chlorine in compound 1 was critical for its antimicrobial activity. The proposed biosynthetic gene clusters for compounds 1 and 2 were found in the genome data of S. curacoi and S. noursei, respectively. The functions of the biosynthetic genes were considered by comparison of the two gene clusters.
Mapping the Inhospitable Landscapes of the Orkney Islands using RPAS
Authors: Hanus Kasper
Published: September 2017

This paper reports the outcome of the RPAS‐based prospection of four prehistoric and early historic sites on Mainland, Rousay and South Ronaldsay Islands of the Orkney archipelago (Northern Scotland). Application of RPAS (Remotely Piloted Aircraft System) improved the effectiveness and accuracy of the mapping of the archaeological landscape, comparing to the ground‐base survey. The paper presents the workflow used to obtain the low altitude images using RPAS and photogrammetric pipeline applied to create ortophotomaps and digital elevation models. Then the interpretation of mapped remnants at the sites of Brough of Deerness, Burrian, Hashwick and Burwick is discussed. Beside reporting the new datasets for the Orkney the author is clarifying the problem of surveying “the inhospitable” landscapes ‐ the areas that for different reasons might be difficult to access by survey using ground‐based methods. Therefore Remotely Piloted Aircraft Systems are advocated as a solution in such challenging conditions.
Near‐Infrared‐Emissive Amphiphilic BODIPY Assemblies Manipulated by Charge‐Transfer Interaction: From Nanofibers to Nanorods and Nanodisks
Authors: Yin Jia‐Fu , Hu Yi , Wang Huan , Jin Zhong , Zhang Yi , Kuang Gui‐Chao
Published: September 2017

A novel near‐infrared (NIR)‐emissive amphiphilic BODIPY derivative, BBDP, was successfully prepared and thoroughly characterized. The photophysical properties in various organic solvents and THF/H2O mixtures with different fractions of water were investigated. BBDP self‐assembled into nanofibers in a water environment owing to its amphiphilic properties. Through charge‐transfer interactions, BBDP co‐assembled with a perylene bisimide derivative, PBI, and a viologen derivative, MV, to generate two superamphiphiles. These two superamphiphiles were able to aggregate in water media at appropriate concentrations. The BBDP–PBI charge‐transfer complex formed nanorods, whereas the BBDP–MV aggregates expressed a disk‐like morphology. This research paves the way for us to manipulate the morphology of dye assemblies.
Mexican case report of a never‐treated Laron syndrome patient evolving to metabolic syndrome, type 2 diabetes, and stroke
Authors: Castilla‐Cortazar Inma , Femat‐Roldán Giovana , Rodríguez‐Rivera Joel , Aguirre Gabriel A. , García‐Magariño Mariano , Martín‐Estal Irene , Espinosa Luis , Díaz‐Olachea Carlos
Published: September 2017

Key Clinical Message

Glucose and lipid profile together with blood pressure should always be considered for low sera‐IGF‐1 patients. Even when adulthood is reached, IGF‐1 therapy in these patients should be pursued as metabolic and protective cellular effects could be triggered. Real incidence of growth hormone insensitivity is still to be uncovered.
Incarcerated giant uterine leiomyoma within an incisional hernia: a case report
Authors: Exarchos Georgios , Vlahos Nikolaos , Dellaportas Dionysios , Metaxa Linda , Theodosopoulos Theodosios
Published: September 2017

Key Clinical Message

Uterine leiomyomas presenting as incarcerated or strangulated hernias in surgical emergencies are extremely rare and should be considered in the differential diagnosis in patients with known uterine fibroids and an irreducible ventral abdominal wall hernia. Detailed history and multidisciplinary approach optimize the diagnosis and decision making toward surgical treatment.
Recurrent TransIent Perivascular Inflammation of the Carotid artery syndrome with temporary carotid plaque on ultrasonography: a case report
Authors: Takamura Akiteru , Hori Ariyuki
Published: September 2017

Key Clinical Message

TransIent Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is a rare syndrome with an unknown cause that is characterized by unilateral neck pain. Its existence as a pathological entity was controversial. We describe a 44‐year‐old male presenting with a 10‐day history of right neck pain diagnosed recurrent TIPIC syndrome with temporary carotid plaque followed by ultrasonography.
Acute drop of platelets in metastatic colon cancer
Authors: Ahmed Ahmed‐Tarig , Gupta Shweta
Published: September 2017

Key Clinical Message

Oxaliplatin is a platinum commonly used in the treatment of metastatic colon cancer. It can cause thrombocytopenia through different mechanism. Sudden isolated drop in platelets should raise the concern for oxaliplatin immune‐induced thrombocytopenia and abrupt discontinuation of the drug. Patients should not be rechallenged with oxaliplatin once diagnosis of OIIT is confirmed.
Improving the Structural Stability of Li‐Rich Layered Cathode Materials by Constructing an Antisite Defect Nanolayer through Polyanion Doping
Authors: Ma Leilei , Mao Lei , Zhao Xiaofeng , Lu Jianhao , Zhang Fan , Ding Pengchong , Chen Lizefang , Lian Fang
Published: September 2017

To mitigate the gradual phase transition and improve the structural stability of Li‐rich layered cathode materials, an antisite defect nanolayer (transition‐metal ions replacing Li+ in a Li slab) with a thickness of approximately 2 nm was induced on the surface of Li1.16(Ni0.25Mn0.75)0.84O2 by doping with boracic polyanions. It is found that the 2 and 3 mol % BO33−‐doped samples show excellent cycling stability with capacity retentions of 91.2 and 93.7 %, respectively, after 300 cycles at 0.5 C. More importantly, the BO33− doping restrains the decay of discharge voltage upon cycling and has the prospect to overcome the fatal drawback of Li‐rich layered oxides. The results demonstrate that the BO33− doping contributes to the generation of an antisite defect nanolayer on the surface, which hinders the formation of Li‐ion vacancies and the continued migration of more transition‐metal ions to the Li slab in a deep charging state. The antisite defect nanolayer clearly improves surface structural stability and inhibits the appearance of the amorphous domain in the bulk, which are favorable to maintain the facile lithium‐diffusion pathways during cycling and improve the capacity retention and rate capability.
Uncertainty evaluation and propagation for spectral measurements
Authors: Schmähling Franko , Wübbeler Gerd , Krüger Udo , Ruggaber Benjamin , Schmidt Franz , Taubert Richard D. , Sperling Armin , Elster Clemens
Published: September 2017

The measurement of the spectral power distribution (SPD) of a radiation source by array spectroradiometers is a technique that is widely used. In many applications, quantities that are derived from the SPD by a weighted integral over a wavelength interval are of interest. These integral quantities ought to be accompanied by a reliable uncertainty statement, for example, to assess conformity with prescribed limits or in order to judge the consistency of results obtained at different laboratories. We have developed a generally applicable Monte Carlo procedure for evaluating the uncertainty of spectral measurements. The procedure naturally accounts for correlations in the SPD which turn out to be crucial. Means are provided to handle and transfer these large‐scale correlation matrices easily. The proposed approach is illustrated by the determination of the SPD of colored LEDs from array spectroradiometer measurements, together with the derived CIE 1931 color coordinates. MATLABTM software implementing the proposed analysis procedure is made available.
Evaluating a formal methodology for dynamic tuning of large‐scale parallel applications
Authors: Martínez Andrea , Sikora Anna , César Eduardo , Sorribes Joan
Published: September 2017

Large‐scale parallel applications performance is usually far from the expected. Dynamic tuning is a powerful technique that helps to improve the performance of parallel applications. To bring this technique to large‐scale computers, this work presents a model that enables decentralized dynamic tuning of large‐scale parallel applications. In this model, applications are decomposed into disjoint subsets of tasks that can be tuned individually but also abstracted to obtain a global view of the parallel application. The proposed model has been designed as a hierarchical tuning network of distributed analysis modules and implemented in the form of ELASTIC, an environment for large‐scale dynamic tuning. Using ELASTIC an experimental evaluation has been conducted over a synthetic large‐scale parallel application and a real agent‐based parallel application. The results show that the proposed model, embodied in ELASTIC, is able to scale to meet the demands of dynamic tuning over thousands of processes, while effectively improving the performance of large‐scale applications.
Children's psychosocial functioning and parents' quality of life in paediatric short stature: The mediating role of caregiving stress
Authors: Silva Neuza , Bullinger Monika , Sommer Rachel , Rohenkohl Anja , Witt Stefanie , Quitmann Julia
Published: September 2017

Objectives

On the basis of the multidimensional model of the caregiving process, this study aimed (a) to compare the levels of quality of life (QoL) and psychological problems of children with short stature and the levels of caregiving stress and QoL of their parents, between diagnostic, treatment, and current height deviation groups, and (b) to examine the direct and indirect links, via caregiving stress, between children's psychosocial functioning and their parents' QoL.

Method

The sample was collected in 5 European countries and comprised 238 dyads of 8‐ to 18‐year‐old children and adolescents with a clinical diagnosis of growth hormone deficiency or idiopathic short stature and one of their parents. The children completed self‐report measures of height‐related QoL (Quality of Life in Short Stature Youth Core Module) and psychological problems (Strengths and Difficulties Questionnaire); the parents reported on their own QoL (EUROHIS‐QOL‐8 Index) and caregiving stress (Quality of Life in Short Stature Youth Effects on Parents subscale).

Results

Children who were treated and who achieved normal height reported better QoL compared to those untreated and with current short stature. Parents of children with idiopathic short stature and current short stature presented greater caregiving stress than parents of children with growth hormone deficiency and achieved normal height. Children's better psychosocial functioning was indirectly associated with parents' better QoL, via less caregiving stress, and these links were invariant across diagnoses, treatment status, and current height deviation.

Conclusions

These results suggest that, along with growth hormone treatments, multidisciplinary interventions in paediatric endocrinology should be family‐centred, by targeting both the children's psychosocial functioning and the parents' stress, in order to improve individual and family adaptation.
Malignant pleural effusion from papillary thyroid carcinoma diagnosed by pleural effusion cytology: A case report
Authors: Kosmas Konstantinos , Tsonou Anna , Mitropoulou Georgia , Salemi Eufrosyni , kazi Danai , Theofanopoulou Ageliki
Published: September 2017

Papillary thyroid carcinoma (PTC) is by far the most common thyroid malignancy (over 85%) of all the thyroid cancers. It has excellent prognosis and 10‐year survival rate in most of the cases (95%). Most of the tumors are indolent and do not recur or metastasize after removal. However, widespread metastases to lung, skeleton, central nervous system and, occasionally, other organs may be observed. In rare instances, this disease may metastasize to the pleura and manifest as a malignant pleural effusion (MPE) and portend poor prognosis. This article reports the cytomorphologic and immunocytochemical findings of a female patient with a symptomatic pleural effusion resulting from PTC metastatic to the pleura. Pleural fluid cytology revealed abundant papillary clusters with relatively nuclear pleomorphism, intranuclear cytoplasmic inclusions and nuclear grooves, small and distinct nucleoli as well as small discrete vacuoles. Psammoma bodies were not seen. Immunocytochemical staining was positive for TGB, EMA, Ber‐EP4, CK19, and negative for TTF‐1. Metastasis of PTC to pleural fluid is extremely rare and diagnosing the disease by cytology is challenging and requires medical expertise as well as knowledge of clinical context and immunocytochemical staining. Additionally, a cytologic diagnosis of MPE due to PTC provides important treatment information and plays an important role in prognosis.