bluuebunny/crossref_metadata_2025 huggingface dataset:
Concise Text Book of Adolescent Health
Authors: Mahmood Dr. Syed Esam
Published: March 2024

This book is an essential guide for 10 to 19 years old, parents, teachers & counselors. It provides information about the health needs and problems of adolescents, National programs and recent initiatives related to Adolescent health in India and recommendations for accelerating the health of adolescents. Important aspects like Mental Health, Role of Parental Concern in Adolescent Health and Helplines for adolescents are included. This book is highly recommended for undergraduate and postgraduate medical, dental, public health as well as masters in social work students.
Supportive Periodontal Therapy : A Comprehensive Review
Authors: Aghanashini Dr. Suchetha , Suprabhan Dr. Surya , B.M. Dr. Darshan , N. Dr. Sapna
Published: March 2024

Supportive periodontal therapy has been considered as the cornerstone of successful periodontal therapy. The successful management of the periodontal disease requires a positive program directed at maintaining and improving the results of treatment as well as preventing the development of the new disease. Hence, in this book, we have presented insightful evidence that has been accumulated about the effectiveness of periodontal therapy.
Emergencies in Ear Nose Throat : Management Pearls
Authors: Nemade Dr. Sanjana Vijay , Shinde Dr. Kiran Jayawant
Published: March 2024

Management of Ear Nose Throat (ENT) disorders is common in the emergency department. There are several critical ENT disorders that warrant immediate recognition and treatment. Early treatment prevents the progression of the disease, minimizes permanent damage and help reversing unwanted complications. With the advancements in the diagnostic modalities and instrumentation, the morbidity and mortality associated with the emergencies has been reduced drastically. The authors have made an honest attempt to include various aspects of emergencies in the field of Ear Nose Throat. This book has been written by the authors keeping in mind the needs of both undergraduate and postgraduate medical students as well as clinicians. Hopefully, it will guide the readers in the early detection and institution of appropriate and adequate treatment for most of the ENT emergencies. This book may be having some lacunae in the first edition, which will be definitely updated in the subsequent editions after the valuable remarks from the esteemed readers.
Previous Years Question Papers for Postgraduate Obstetrics and Gynaecology Examinations
Authors: Patil Dr. Madhu A
Published: March 2024

A comprehensive book on the previous years question papers of obstetrics and gynaecology, mainly intended for the postgraduate who are appearing for the exams. This book contains chapterwise arrangement of questions from the chapters which will make easy for the exam going students to read and revise. I wish all the postgraduates to make use of this book and have a happy learning process.
Pain in Endodontics
Authors: Bora Dr. Deepjyoti , N. Dr. Sridevi , Priyadarshi Dr. Pankaj
Published: March 2024

This book provides information about diagnosis pain pathways and the differential diagnosis of pain summarizing all the topics of referred pain. Management of pain and also the new advancement in the diagnosis and treatment procedures of endodontic pain.
Endodontic pain is a complex symptom that poses unique challenges for the dentist. This book is a concise, well-structured guide to the assessment and treatment of patients who present with endodontic pain, in which step-by-step descriptions are complemented by informative images and flow charts. 
The advantages, disadvantages, and significance of specific diagnostic and treatment procedures are clearly described, as is a pharmacotherapeutic approach to the prevention and treatment of pain.
In addition, the causes and biological basis of endodontic pain are explained and guidance is provided on further strategies for pain prevention.
Pain and periapical infections are the most common complaints with which patients approach a dental surgeon and endodontic therapy is one of the most common dental procedures. The endodontic pain is mainly caused due to the inflammation of the pulp tissue occurring as a result of dental caries progressing deep into the tooth.
Handbook of Gynaecpathology – A Simplified Approach in Nutshell
Authors: K Dr. Anandraj Vaithy. , Samal Dr. Rupal
Published: March 2024

The chapters in this book cover the common lesions encountered in the stream Gynaecpathology with an emphasis on tumours and recent classifications and staging. The book includes tables in coloured background and flowcharts in a simplified approach. Classification and categorization lesions are depicted in a schematic approach aiding the students to review the contents hassle-free. Classical gross and microscopical images from collections with the possible differential diagnosis are also included. Hope the book caters to the needs of students, residents of Gynaecology and Pathology.
Pleomorphic Adenoma
Authors: Kolay Sumanta Kumar , Kumar Satish , Kumar Pratiksha
Published: March 2024

This book is written about a very important topic in oral pathology and according to the syllabus of dentistry. Very hard work has been done during the writing of book. This book is a collection of various aspects of clinical features, pathology, and mode of surgical treatment of Pleomorphic Adenoma. This outstanding resource has been completely updated to include current techniques and materials developed for a student of postgraduate, undergraduate, and oral pathologist. The content of all chapters good to understand with the histological background.
Management of Abiotic Stress in Crop Plants
Authors: S Dr. Gurumurthy , S Dr. enjam Jinus
Published: March 2024

The talk of the ‘new normal’ i.e. climate crises has become louder and louder in the present era. It is unparalleled to compare the rate of today’s climate crises with that of the last 2000 years. With the increasing population which is 7 billion at present and expecting to increase at 10.5 billion in a period of 70–80 years, the concern for food security is a must as the impacts of climate crises has now become monstrous. The present condition adversely affects more of the arid and semiarid zones of the world. Therefore, smart mitigation and adaptation strategies are to be elevated for environmental sustainability.

Climate crises also lead to abiotic stresses; such as, drought, salinity, temperature, waterlogging, heavy metals and so on which result in hamper crop growth, less productivity, less time for accumulation of biomass, and food insecurity as a whole. Crop improvement through advanced molecular and plant breeding programmes using the available plant genetic resources that can cope with the changing climate crises is the need of the hour.

This edited book is a contribution of the genuine researchers and scientists who have been concerning much about abiotic stress and its crop management strategies using recent molecular advances and moreover aims to sustainability to serve Mother Nature.

The essence of this book is that it opens the world of proven possibilities of making a sustainable development through the utilization of available genetic resources, exploration of conventional and non-conventional plant breeding methods, advanced management practices, and governmental policies and schemes by squeezing every potentiality out of it. It will be of great benefit for future researchers, scientists, academician, and the public.
A Textbook on Entrepreneurship Development Programme in Sericulture
Authors: Bhat Dr. Muzafar Ahmad , Chanotra Dr. Suraksha , Buhroo Dr. Zafar Iqbal , Aziz Mr. Abdul , Azam Dr. Mohd.
Published: March 2024

The word ''Entrepreneur'' has been taken from French word which means risk-takers. Someone who organizes a business venture and assumes the risk for it. In sericulture, Entrepreneurs can be silkworm rearers i.e., chawki rearers, cocoon growers, seed producers, reelers, weavers etc. Entrepreneurship can be defined by describing what entrepreneurs do. For example, "Entrepreneurs use personal initiative and engage in calculated risk-taking, to create new business ventures by raising resources to apply innovative new ideas that solve problems, meet challenges, or satisfy the needs of a clearly defined market”. But as the following definition states, entrepreneurship is not restricted to business and profit but Entrepreneurship involves bringing about change to achieve some benefit. This benefit may be financial but it also involves the satisfaction of knowing that you have changed something for the better.

Entrepreneurship is essentially the act of creation requiring the ability to recognize an opportunity, shape a goal, and take advantage of the situation. Entrepreneurship plans, persuades, raise resources, and give birth to new ventures. The term 'Entrepreneur' is often used interchangeably with 'Entrepreneurship', but conceptually they are different, yet they are just like two sides of a coin. 'Entrepreneur' refers to a person while 'Entrepreneurship' refers to the function. Entrepreneur and Entrepreneurship are positive and valued oriented concepts. Entrepreneurship development is a systematic and organized effort of human development. It is a process of enhancing the motivation, knowledge, and skills of the potential entrepreneurs a r o u s i n g a n d r e fo r m i n g e n tr e p r e n e u r i a l b e h a v i o u r. In Entrepreneurship Development, persons are prepared to face business uncertainty and risks. Thus, it is said that Entrepreneurship are not born; they can be developed through trainings.
Short Textbook in Orthopaedics and Rehabilitation
Authors: Agrawal Dr. Aditya K. , Golwala Dr. Paresh
Published: March 2024

The book is divided into two volumes and ten sections. It deals with topics pertaining to Basic Sciences, Trauma, Cold Orthopaedics, Spine, Tumours, Hand and Wrist, Recent Advances as well as Clinical Examination and Multiple Choice Questions. The book is written by well trained and experienced Professors from various reputed institutions of India and abroad. The book will serve as a readymade reference guide to various undergraduate medical students, physiotherapy students and postgraduate students who want to score in their various exams and gain knowledge in the field of orthopaedics. The book will be helpful to the students to know what is expected from them to write in theory exams and to examine in the clinics. The readers are requested to read standard textbooks in various specialities of orthopaedics for complete knowledge as stated in the references.
Medical Knowledge and Education (A Book of Questions and Answers), 2020 Edition
Authors: MD Prof. Dr. Atul Choube
Published: March 2024

Salient Features

The book incorporates current trends in diagnosis and treatment of medical problems. 
It is a useful tool for knowledge of all medical subjects, current medical education, and research.
The book will be helpful to medical students pursuing both undergraduate and postgraduate medical courses in all subjects.
The book will also be a guiding light to doctors appearing in competitive examinations and job interviews.
Highlights of the book include questions and answers. Answer contains short, long or essay type comments which cover both theory and practical aspects on the topic.
Notes on Medical Microbiology for Dental Students
Authors: Bareja Dr. Rajesh
Published: March 2024

This book consists of topics according to the syllabus of dental (BDS) stream. It consists of – General Microbiology, Immunology, Bacteriology, Virology, Mycology, Parasitology and Applied Microbiology. The book comprises the diagrams and flowcharts accordingly.

Since 2009, I have been teaching medical and dental students. For medical students, however, various options are available but for dental students limited books are available. Some students and faculty members gave me opinion to publish my notes in the form of book. After proper discussion with dental students, I have come to know their requirements. Now I have prepared my notes in form of book that consists of concise information which is sufficient and according to the syllabus of DCI. This book consists of easy language, concise and proper information for concepts with flow charts, diagrams and expected question that can be asked in examination.

Dear students, remember, this book is for you, if you find any difficulty to understand any topic or you want to modified any chapter according to your need, then you can contact me through my email without any hesitation. I will try my best to fulfil your requirement.
Dental Caries (Its Understanding and Management) Then & Now
Authors: Mittal Dr. Rishu , Gupta Dr. Saurabh
Published: March 2024

It gives us immense pleasure to connect with you, through this book on Dental Caries. We once again thank almighty God for his blessings in all our endeavours. 
The book attempts to incorporate recent concept of Dental Caries while at the same time not losing the sight of basics, therefore, making the study on Dental Caries easier and interesting. The main feature of this edition is a new format wherein the flow charts and photographs are in plenty to help the students undertake review and revision. This book would not have been possible without the help and motivation of our teachers and colleagues. We are thankful to all the contributors for their respective help in this book and for critically evaluating the chapters.
We offer our humble gratitude and sincere thanks to Principal Dr. I. K. Pandit for providing healthy and encouraging environment for our work. We wish to thank all our colleagues at J. N. Kapoor DAV (C) Dental College, Yamunanagar, who gave helpful advice while editing of the text.
We are thankful to our passionate publisher, Innovative Publications for showing personal interest and trying their level best to bring the book in the present form. Last but not least, we would like to thank all the authors, editors and publishers for providing great help in editing this edition of this book. It is hoped that all these modifications will be appreciated and render the book more valuable basis. We shall be highly indebted to our readers, if they analyze the text critically and send us useful suggestions for improving quality of this book for the next edition.
A Textbook of Pharmacy Practice (For B. Pharm 7th Semester, 4th Year)
Authors: Rajput Hakim Singh , Sharma Dr. Uma Shankar , Yadav Dr. Vimal Kumar
Published: March 2024

The syllabus, course and world of pharmacy is dynamic and always in state of betterment. Understanding the needs and requirements of students and teachers this text book can be a great work. It gives us immense pleasure to place the book on 'Pharmacy Practice' strictly according to the new syllabus of B. Pharm 7th Semester as recognized by the Pharmacy Council of India, New Delhi.
This book has been structured, written and arranged in such a way to provide very clear understanding of all the topics related to Pharmacy Practice.
This book covers knowledge about the hospital and hospital pharmacy, community pharmacy, clinical pharmacy, therapeutic drug monitoring, patient counseling, whole sale and retail drug store, inventory control and drug store management etc. which are the broad area where pharmacist has opportunity to practice.
This book is specially designed for B. Pharm students and covers many aspects of Pharmacy Practice. In this text book we tried to arrange basics in concise and accurate form.
Honestly, we believe that students will get a broad knowledge of pharmacy practice profession which will be useful for their growth.
COVID-19 Pandemic: New Challenges and Strategies
Authors: Rana Usha , Govender Jayanathan
Published: March 2024

The COVID-19 outbreak affects all segments of the population and is particularly detrimental to members of those social groups in the most vulnerable situations; It continues to affect populations, including people living in poverty situations, older persons, persons with disabilities, youth, and indigenous peoples. Early evidence indicates that the health and economic impacts of the virus are being borne disproportionately by poor people. For example, homeless people, because they may be unable to safely shelter in place, are highly exposed to the danger of the virus.

People without access to running water, refugees, migrants, or displaced persons also stand to suffer disproportionately both from the pandemic and its aftermath – whether due to limited movement, fewer employment opportunities, increased xenophobia, etc. If not properly addressed through policy, the social crisis created by the COVID-19 pandemic may also increase inequality, exclusion, discrimination, and global unemployment in the medium and long term. Comprehensive, universal social protection systems, when in place, play a much durable role in protecting workers and in reducing the prevalence of poverty since they act as automatic stabilizers. That is, they provide basic income security at all times, thereby enhancing people’s capacity to manage and overcome shocks.

This book aims to bring together research that explores the socio-psycho impacts of the COVID-19 pandemic on countries, regions, and key sectors. In addition, it explores the various ‘opportunities’ that have been identified in moving out of this crisis, such as the promotion of a more cohesive society. Also, within the scope of this book is research reporting on decisive measures taken to future-proof economies and increase countries’ or sectors’ resilience.
Current Concepts on Mental Health of Children and Adolescents (A Treatise on Psychiatric Disorders)
Authors: MD Professor Dr. Atul Choube
Published: March 2024

This book is a comprehensive coverage of mental disorders common in children and adolescents. It contains 43 chapters which cover mental illnesses such as anxiety disorders, obsessive compulsive disorder, bipolar disorder, attention deficit hyperactivity disorder and dissociative disorders. Special emphasis is on problems of suicide, depression, and substance use disorders. The neuropathology and neuroimaging studies have been included to identify the etiopathogenesis and appropriate therapies for the disorders. Psychedelic therapy, telepsychiatry, and neuromodulation are highlighted in the book. The book is useful for undergraduate and postgraduate medical students of paediatrics, medicine, and psychiatry, medical teachers and medical professionals as well as clinical psychologists who provide counselling and behavioural therapy to children and adolescents.
Abridged Forensic Medicine and Toxicology For MBBS 3rd Prof. Part-1 & Undergraduate Students
Authors: Garg Dr. Vishal
Published: March 2024

During my whole study period I always wanted to have a compact description of every subject after reading all the heavy load books. So to comply with my needs I started writing short notes on scattered topics of various subjects of medicine which were useful specially during final exams. This inspired me to make similar concise notes in my subject which I later presented as a book . This book will serves as a ready-made reference guide to various undergraduate medical students.
Human Anatomy Set of 3 Volumes
Authors: Kumar Dr. A. Prasanna Veera
Published: March 2024

The chapters are organized as per the CBME curriculum. There is complete coverage of all MCI competencies serial-wise. Anatomical basis has been given utmost importance while dealing with the competencies. All the competencies were dealt with by taking into consideration recent advances in medicine.
Evidence Based Treatment Protocol (Evidence Based Education System)
Authors: Chauhan Dr. Nirali , Baria Dr. Dipika
Published: March 2024

The practice of evidence based medicine is relatively straightforward and requires an ordered approach which includes identification of clinical problem, formulation of clear questions, list out relevant outcome and search best available evidence. Clinicians have to decide how to use information gathered from patients, articles, researches & experts in their respective fields. It is very essential to use systematic approach which makes process easier and approaching problem more logical. Evidence-based guidelines are becoming an important and indispensable part of quality healthcare because of their potentials to improve quality and reduce cost of health-care.
Clinical protocol is systematically developed statements, informed by research evidence, values and local or regional circumstances to assist fair decisions and judgments about health care at the clinical, management and policy levels(Browman, Brouwers, Fervers, and Sawka, 2009)
Evidence based treatment protocols incorporates best available evidence for generation of protocols which are important for decision making and uniformity in treatment of patients. This book has incorporated the recommendations with best available evidence in form of systematic review, meta-analysis, randomized controlled trials given by Centre for Evidence-Based Medicine (CBME), Oxford; www.cebm.net for development of protocols.
Competency Based Clinical Biochemistry - A Practical Manual for First MBBS Students
Authors: Nusrath Dr. Aliya , A Dr. Rajeshwari , N Dr. Asharani
Published: March 2024

The book has following unique features:

Comprehensive coverage of practical syllabus based on Biochemistry skill competency specified in CBME curriculum.  
All experiments have defined Specific Learning objectives and Resources required.
All experiments also specify predominant domain, level of competency as per Miller's pyramid, suggests teaching learning and assessment methods.  
Sixty case studies have been included correlating the biochemical basis of clinical manifestations and rationale of using laboratory investigations in diagnosis of the disease. 
Objective Structured Practical Examination (OSPE) experiments are included, having both Performance and Response type of assessments. 
The OSPE performance assessments are unique based on the case studies. 
Forty-five image-based spotters have been included adding to clinical correlation training of students which can also be utilized as assessment tools for OSPE/ Spotters.
Medical Knowledge and Education - Volume II (2e)
Authors: MD Professor Dr. Atul Choube
Published: March 2024

This book on Medical knowledge contains twelve chapters viz Endocrine diseases, Gastrointestinal hepatic and biliary diseases, Cardiovascular diseases, Hematologic disorders, Neurologic disorders, Musculoskeletal disorders, Dermatologic diseases, Diseases of the eye, Diseases of the ear nose and throat, Gynaecologic and Obstetric disorders, Diseases of the kidney and urinary tract, Diseases of the lungs. The book is useful for medical students of undergraduate, postgraduate, and superspecialties medical education, practicing pediatricians, medical teachers and researchers, and all those people who are involved in care of persons with diseases and disabilities.
Adaptive, Persistent, and Available Support: The Crucial Way in Healthcare during Covid-19
Authors: Wilmar Maria Wramsten , Lesauvage Hanna
Published: March 2024

The aim of this study was to gain knowledge about the work of crisis managers in healthcare during the COVID-19 pandemic. A qualitative and exploratory approach was used with crisis managers who had worked at five different emergency hospitals in one of the Swedish metropolitan regions. An inductive thematic analysis was performed. Major emphasis was placed on the importance of work processes aiming for a high level of accessibility, including having a tangible physical presence in the workplace, plus actively reaching out to the staff. The crisis support provided was adapted to provide a stabilizing factor, promote stamina, and increase motivation. It also included a continuous assessment of mental health status and focused on strengthening management functions. Initially, the support was more focused on stress and anxiety, but then gradually shifted towards maintaining stamina and motivation
A preliminary study of direct observation and selected water quality monitoring in Putrajaya Lake: the status between October-December 2022
Authors: Azhar Nur’ain , Yap Chee Kong , Nulit Rosimah , Omar Hishamuddin , Syazwan Wan Mohd , Leow Chee Seng
Published: March 2024

The objective of this study was to provide the status of water quality based on a direct observation and selected water quality parameters (nitrite, ammonia, and pH) monitoring study between October-December 2022. Between October and November 2022, the levels of the above three surface water quality parameters were measured in 6 different sites throughout Putrajaya Lake. Observational pictures of the sites were also taken, and water samples were collected. In addition to the above observation and water quality monitoring study, the rainfall data was collected from 17th October 2022 to 11th December 2022, cited from the official website of Public Infobanjir (https://publicinfobanjir.water.gov.my/?lang=en) at stations Sg. Anak Gajah and Sg. Limau Manis, was also used to understand the possible correlation. However, further studies are needed. It was found that the water quality status was in good condition, making Putrajaya Lake a safe and suitable lake for aquatic life and recreational activities between October -December 2022. This could be due to the sustainable practices and rainwater harvesting system already implemented at Putrajaya Lake. Putrajaya Lake's water quality monitoring and sustainability practices were well implemented. However, regular maintenance to provide acute monitoring of water quality data at Putrajaya Lakes is necessary in the future.
Neuraxial Block in A Post-Hemorrhagic Stroke Pregnant Patient
Authors: Iswara Ida Bagus Reza Nanda , Jeanne Bianca , Suranadi I Wayan
Published: March 2024

The selection of anesthetic methods for labor and delivery in individuals with elevated intracranial pressure relies on careful consideration of the risks and benefits. While neuraxial analgesia and anesthesia are favored for healthy individuals, they might not be suitable for individuals with intracranial lesions or a heightened risk of bleeding. Neuraxial block in post-stroke patients raises a concerning question about its safety due to the risk of herniation. The risk of perioperative major vascular events and mortality between general anesthesia and regional anesthesia in post-stroke patients is comparable. However, the neuraxial block shows benefits regarding airway manipulation and lower risk of thromboembolism. A successful and safe neuraxial anesthesia in a pregnant patient with a history of hemorrhagic stroke was presented in this case report.
Special methods of magnetic resonance in diagnosis of multiple sclerosis.
Authors: Turchinskaya I. A. , Sheriev S. R. , Efimtsev A. Yu. , Trufanov G. E.
Published: March 2024

The article is devoted to the review of the most promising MRI techniques in the diagnosis of multiple sclerosis as part of personalized medicine. A brief description of the current state of the problem is provided. Examples of promising MR research techniques are considered. The issues of clinical importance and expediency of using these techniques are discussed. The existing approaches in the diagnosis of multiple sclerosis are summarized. In conclusion, the prospects and importance of the considered methods in the structure of healthcare are summarized.
Identifying Immunological Markers for Bowel Cancer.
Authors: Bayramova N. S.
Published: March 2024

The role of immunological processes in the pathophysiology of colorectal cancer has received a lot of attention lately and has been extensively researched. Immune processes are significantly regulated by cytokines and antimicrobial peptides (AMP). Numerous studies have demonstrated the significance of cytokines in the prognosis and surveillance of malignant oncological illnesses. In group II, the blood serum concentration of Calprotectin was found to be greater in 13 patients (92.0 %) and lower in 1 patient (8.0 %) compared to control limits (χ = 24.27, p < 0.001). The obtained results show that, in comparison to the control group, the concentration of Calprotectin rises statistically consistently by 3.5 times, with a coefficient of integrity of p < 0.001. According to the data, there is a statistically significant rise in Calprotectin concentration (3.5 times higher than in the control group) with a p-value of less than 0.001. The average mathematical density of this indicator is 3.42 ± 0.48 pg/ml, the minimum density is 0.7 pg/ml, and the maximum thickness is 6.1 pg/ml.
Achievements and prospects for further development of photodynamic therapy technology in the treatment of cerebral tumors
Authors: Kukanov K. K. , Nechaeva A. S. , Ulitin A. Yu. , Sklyar S. S. , Vershinin A. E. , Dikonenko M. V. , Politova A. O. , Papayan G. V. , Olyushin V. E.
Published: March 2024

Literature review reflects the current status and development status of intraoperative photodynamic therapy in neurooncology and discusses the results of the most important studies on photodynamic therapy (PDT). We searched the Pubmed, EMBASE, Cochrane Library and eLibrary databases for publications published between January 2000 and December 2022. Found 204 publications in foreign sources and 59 publications in domestic editions, dealing with the issues of photodynamic therapy in neurooncology. An analysis of the literature has shown that intraoperative PDT in neurooncology is an important tool that contributes to increasing the radicality of the operation and local control. The basic rationale for the effectiveness of PDT lies in the study of the pathways leading to the complete devitalization of a malignant tumor, the study of the mechanisms of the local and systemic immune response. In addition, subcellular targets in PDT are determined by the properties of photosensitizers (PS). Second generation PSs have already been introduced into clinical practice. The effectiveness of PDT using photoditazine, 5-aminolevulinic acid has been demonstrated. The mechanisms of action and targets of these PS have been established. In Russia, a number of studies have repeatedly shown and proved the clinical effectiveness of PDT in groups of neurooncological patients with glial tumors and secondary metastatic tumors, but so far, the method has not been included in the clinical guidelines for the provision of high-tech neurosurgical care. There is certainly a need for further development of PTD techniques in neurooncology, especially in patients at high risk of recurrence and aggressive CNS tumors.
The level of blood neutrophils primary reactive oxygen species production in Graves’ disease patients undergoing conservative therapy with thiamazole.
Authors: Dudina M. A. , Dogadin S. A. , Savchenko A. A. , Gvozdev I. I.
Published: March 2024

Background. Conservative therapy with thiamazole in Graves’ disease helps to reduce the level of oxidative stress by restoring euthyroidism and the total reactive antioxidant potential of plasma. However, until now, in patients with Graves’ disease, the radical-producing ability of neutrophils remains unexplored at the initial stage of free radical conversion at different durations of drug-induced euthyroidism, which seems significant in revealing the mechanisms of disease recurrence. The aim is to study the level of production of primary reactive oxygen species in peripheral blood neutrophils depending on the duration of drug — induced euthyroidism in patients with Graves’ disease. Materials and methods. A single-center, prospective, controlled study was conducted with the participation of patients with laboratory-confirmed Graves’ disease. Subgroups of patients with Graves’ disease were formed depending on the duration of achieved drug-induced euthyroidism with continuous conservative therapy with thiamazole. The level of ROS production in peripheral blood neutrophils was determined by chemiluminescence. The assessment of spontaneous and zymosan-induced chemiluminescence was carried out for 90 minutes on a 36-channel chemiluminescence analyzer BLM-3607 (Medbiotech LLC, Krasnoyarsk). Results. The study included 102 Graves’ disease women with an average age of 47.54 ± 15.47 years. Of these, 75 (73.5 %) with relapse and 27 (26.47 %) with newly diagnosed disease. The total synthesis of (S) primary ROS increased statistically significantly relative to the control values in the examined patients with a duration of the euthyroid state of 5–8 and 9–12 months. It was found that in patients with Graves’ disease with stable drug-induced euthyroidism for 5–8 and 9–12 months, the S index of zymosan-induced lucigenin-dependent chemiluminescence of neutrophils increased statistically significantly, respectively, by 10.7 and 7.4 times relative to the control values. Conclusion. The restoration and maintenance of drug-induced euthyroidism for more than 12 months against the background of conservative thiamazole therapy in patients with Graves’ disease reduces the load of systemic oxidative stress on the immune system. However, the high total production of primary ROS in neutrophils of patients with Graves’ disease in a state of drug-induced euthyroidism with conservative thiamazole therapy may play a significant role in disconnecting the functioning of the NADPH oxidase complex and determine the functional capabilities of neutrophils in case of disease recurrence.
Ortaokul Ders Kitapları Geometri ve Ölçme Öğrenme Alanındaki Konuların Gerçekçi Matematik Eğitimi İlkelerine Göre Analizi
Authors: Korkutan Ebru , Oflaz Gülçin
Published: March 2024

Araştırmanın amacı, ortaokul matematik ders kitaplarında geometri ve ölçme öğrenme alanlarında gerçekçi matematik eğitimi ilkelerine ne sıklıkla rastlandığını belirlemektir. Bu amaçla çalışmada doküman analizi tekniği benimsenmiştir. Çalışma kapsamında incelenecek kitaplar ölçüt örnekleme tekniği kullanılarak belirlenmiştir. Bu bağlamda, farklı yayınevlerine ait dört kitabın geometri ve ölçme alanında bulunan 720 görev incelenmiştir. Ders kitaplarındaki görevler, araştırmacıların hazırlamış olduğu kodlama matrisine göre analiz edilmiştir. Bu matrisin oluşturulmasında gerçekçi matematik eğitiminin ilkeleri olan aktivite, gerçeklik, sarmal yapı, seviye, etkileşim ve rehberlik esas alınmıştır. Bu ilkelerin özelliklerini kitapta yansıtabilecek kodlar belirlenmiş ve kodlama matrisi oluşturulmuştur. Belirlenen matematik kitaplarındaki görevler kodlama matrisi doğrultusunda incelenmiştir. Analiz sonucunda elde edilen verilere ait frekans ve yüzde değerleri grafikler vasıtasıyla sunulmuştur. Çalışmanın sonucuna göre, matematik öğretim programının temel hedefleri ile hazırlanmış ders kitaplarının içeriklerinin paralellik gösterebilmesi için ders kitaplarında öğrencilerin aktif olduğu, yaratıcı düşünebilme ve sosyal becerilerini geliştirebilecekleri görevlerin sayısı arttırılmalıdır.
Examining the dynamics of risk, performance, and volatility during COVID-19: Evidence from Moroccan stock market
Authors: Amzil Mustapha , Bari Ahmed Ait , Asllam Lahoucine
Published: March 2024

This study delves into the repercussions of the COVID-19 pandemic on the Moroccan stock market, with a specific focus on the MASI index and sectoral indices. The examination en-compasses distinct pre-COVID and during-COVID periods, shedding light on the market’s evolution, marked by unique phases and fluctuations. Notably, the MASI index experienced a significant downturn in March 2020, indicative of the pandemic’s disruptive impact on investor behavior. Despite this setback, the market showcased remarkable resilience, staging a swift recovery and surpassing pre-crisis levels by the close of 2020. This rebound can be attributed to various factors, including historically low bond yields, the initiation of vaccination campaigns, and the resumption of dividend payouts by the banking sector. Our findings bring forth a nuanced understanding of performance and risk dynamics across individual sectors. Moreover, there is a noteworthy surge in correlations between sectoral returns during the COVID-19 period, limiting diversification options for investors and exposing them to heightened risks. The volatility patterns, analyzed using GARCH models, underscore the dynamic nature of the MASI index, exhibiting stability in the pre-pandemic phase and a transient disturbance during the initial pandemic shock. This study contributes to the existing body of literature on the global financial impact of COVID-19, providing valuable insights into the Moroccan context. The results emphasize the significance of comprehending sector-specific vulnerabilities and market dynamics for both investors and policymakers. In navigating the uncertainties of the post-pandemic era, these insights offer crucial perspectives for market participants to make informed decisions and adapt optimal strategies.
Improve speaking skills with Duolingo’s mobile game-based language learning
Authors: Kazu Ibrahim Yasar , Kuvvetli Murat
Published: March 2024

The purpose of this research is to evaluate the effectiveness of Duolingo's game-based methodology in improving speaking proficiency within mobile language learning, while also examining the specific attributes and strategies contributing to its success and exploring implications for language education and learner optimization. Given the growing prevalence of mobile language learning platforms, the research meticulously scrutinizes the specific attributes and strategies employed by Duolingo that contribute to the refinement of oral fluency. This study employs a mixed methods design, integrating phenomenological and experimental approaches through a pre, post and attainment speaking tests with a control group design supported with metaphorical perceptions. The findings underscore the pivotal role of assimilating technological advancements and gamified pedagogical approaches within language education to expedite effective intercultural communication across multifarious linguistic landscapes. Furthermore, the results emphasize the importance of continuously adapting language learning methodologies to leverage emerging technologies and gamification strategies in order to foster effective communication skills in diverse linguistic contexts. The implications for prospective inquiries advocate for longitudinal investigations delving into the enduring implications of mobile game-based language learning on comprehensive linguistic acquisition, necessitating comparative inquiries to ascertain the comparative efficacy of diverse mobile applications in fostering distinct language proficiencies. Additionally, probing the influence of individual learner attributes and predilections in optimizing the utilization of mobile language learning applications could yield valuable insights for tailoring language acquisition paradigms.
Diagnostic Accuracy of Emergency Physician - Focused Cardiac Ultrasound (EP-FOCUS) in Emergency Department
Authors: Mohamed Hussein Nada , Nasreddin Mohamed Ezzat , Ibrahim Wesam , Elsheikh Raghda Ghonimy , Saber Ahmed Mohamed
Published: March 2024

Emergency physician (EP)-performed Focused Cardiac Ultrasound (EP FOCUS) is an important skill for the care of patients with potentially life-threatening presentation as chest pain, shortness of breath, shock or post-trauma. However, this relatively new skill in hands of emergency physicians may be less accurate compared to conventional Echocardiography. This study aimed to measure the diagnostic accuracy of bedside focused ultrasound cardiac examination in hands of emergency physicians (EP-FOCUS) in assessment forementioned presentation compared to findings verified by conventional Echocardiographers. This cross-sectional study was carried out on 100 patients aged from 18to 88 years old, both sexes, presented with acute onset of being unwell, dizziness, shortness of breath (SOB), transient loss of consciousness (TLOC) and blunt or penetrating chest trauma with provisional diagnosis of pericardial effusion, pulmonary embolism, ascending aortic dissection or congestive heart failure. EP-FOCUS was conducted and results compared with that of conventional Echocardiographer. Finally, diagnostic accuracy was calculated. Results: As a diagnostic for congestive heart failure, EP-FOCUS showed sensitivity, specificity, positive pressure ventilation (PPV), negative pressure ventilation (NPV) and accuracy 73, 88, 78, 84 and 83 respectively with measure of agreement kappa about 0.715. Regarding Pericardial Effusion EP-FOCUS showed sensitivity, specificity, PPV, NPV and accuracy of 86, 96, 93, 92 and 93 respectively with measure of agreement kappa about 0.826. As a diagnostic for pulmonary embolism EP-FOCUS showed sensitivity, specificity, PPV, NPV and Accuracy of 50, 92, 75, 81, and 80 respectively with measure of agreement kappa about 0.567. EP-FOCUS in trained hands can assist in accurate, timely diagnosis of such critical conditions and in its management consequently with acceptable accuracy.
Pattern of Bacteriological Profile of Wound Infections in Caesarean Section and their Anti Biogram; A Study from a Tertiary Care Women and Children Hospital, Puducherry, India
Authors: Gopal Vani , B. Radhakrishnan Aruna , Boblee James Jyoti
Published: March 2024

Wound infection was the common consequence after cesarean section (CS) in pregnant women. High cost burden, longer duration of hospital stay, dissatisfaction of patient, morbidity, and mortality of the pregnant women are the common consequences of surgical site of wound infection. The aim of the present study is to determine the pattern of bacterial pathogens in wounds of Caesarean section in a tertiary care maternity and children hospital and to identify the antibiogram pattern of the bacterial isolates in wound infections of Caesarean section. This is a hospital based retrospective study conducted in the Department of Microbiology in Rajiv Gandhi Government Women and Children Hospital Puducherry, a tertiary care hospital totally 309 wound swabs collected from patients. Out of 309 samples 247 samples were positive for bacterial isolates showing positivity rate of 79.9%. In this study, Staphylococcus aureus (33.6%) was the predominant pathogen isolated which is frequent cause of surgical site infections (n=83). Most common Gram negative bacterial isolates (66.4%) causing wound infection in the present study was Escherichia coli (32.7%) followed by Klebsiella species (19%), Pseudomonas (11%), Proteus (1.6%), Acinetobacter (0.4%), Providencia (0.4%). Regarding antibiogram of Staphyloccocus aureus, Amikacin, cefaperazone sulbactum, meropenam, linezolid, vancomycin, gentamycin, cotrimoxazole were highly sensitive. This present study gives an insight of the type of bacterial isolates causing wound infections in caesarean sections and their antibiogram. This will help the clinicians to plan for Empirical therapy.
The Effect of Soil Salinization on Quantitative Indicators of Photosynthetic Pigments of Vicia
Authors: Makhmudjonovna Ismoilova Karomatkhon , Hamdamovich Kuliyev Tojidin , Muxammadkodirovna Sultonova Nigorakhon , Bakhodirkizi Karimova Shoira
Published: March 2024

This article contains information on the effect of soil salinization on quantitative indicators of photosynthetic pigments of plants. The hairy vicia plant (Vicia villosa Roth) was chosen as the object of research. This plant has been studied in conditions of weak, medium and highly saline soils. The results showed that an increase in soil salinity led to a decrease in the amount of chlorophyll (Chl) «a», an increase in the content of chlorophyll (Chl) «b» and carotenoids (Car). It was found that during the growing season, the leaves of plants in the blooming phase contain a large amount of pigments. In slightly saline soil, the content of chlorophyll «a» in plant leaves was 5.42 mg/g, and in highly saline soil -4.88 mg/g. The content of (Chl) «b» increased from 1.89 mg/g to 3.19 mg/g, respectively. This is exactly the result observed for carotenoids (Car), recording an increase of 1.69 mg/g from 1.45 mg/g. When determining the amount of photosynthetic pigments in plants in saline soil conditions, it was considered advisable to use leaves during the blooming period.
Seroprevalence of anti-SARS-CoV-2 Antibodies among Slaughterhouse workers in Burkina Faso
Authors: Zida Sylvie , Ouédraogo Henri Gautier , Ouédraogo Oumarou , Soubeiga Serge Théophile , Zouré Abdou Azaque , Compaoré Tegwindé Rebeca , Sagna Tani , Kambiré Dinanibè , Dabiré Sanhitouo Charlemagne , Zongo Dramane , Dicko Amadou , Kouanda Seni
Published: March 2024

The first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recorded in the Wuhan seafood market, where a variety of mammalian animals are sold live and for direct consumption and the resulting pandemic has once again highlighted the role of human-animal interaction in the spread of pathogens. The objective of this study was to evaluate the seroprevalence of SARS-CoV-2 among slaughterhouse workers in Burkina Faso. We carried out a cross-sectional study among slaughterhouses workers of Ouagadougou and Bobo Dioulasso between March and April 2021. We collected sociodemographic data and we performed ELISA tests to determine the presence of anti-SARS-CoV-2 antibodies. Anti-SARS-CoV-2 antibodies in slaughterhouse workers serum samples. We included 183 participants. Among these, 79 resided in Ouagadougou and 104 in Bobo Dioulasso. The majority of participants were men (179/183, or 97.81%) and the average age was 33.87 years. Of the 183 samples analyzed, 140 (76.50%) were found to be positive for anti-SARS-CoV-2 antibodies, including 76/104 (73.07%) in Bobo Dioulasso and 64/79 (81.01%) in Ouagadougou. Univariate analysis showed no significant association between SARS-CoV-2 seropositivity, sociodemographic data, professional profile and personal hygiene. The seroprevalence of COVID-19 among slaughterhouse workers was high in 2021. These results highlighted the circulation of SARS-CoV-2 within this population and demonstrate a high exposure of these professionals to virus.
Expression of PfHRP-2 Antigen in the Saliva of Malaria Patients
Authors: hayati Nur , Harminarti Nora
Published: March 2024

Malaria diagnosis is relatively easy, but making the blood film is still an obstacle in the field because it is invasive, requires expertise, and increases the risk of transmission of infectious diseases. Antigen detection of several microorganisms in saliva, the opportunity to make saliva as an alternative diagnostic specimen for malaria. This study examines the presence of malaria parasites PfHRP-2 antigen in saliva. Saliva was collected from falciparum malaria patients in some health centers in West Sumatra. PfHRP-2 antigen was examined by ELISA using a kit called CELISA antigen. PfHRP-2 antigen detection in saliva specimens was evaluated in the presence of Plasmodium falciparum on blood film as a gold standard. Out Of the 64 patients whose positive Plasmodium falciparum was confirmed by microscopy, 63 people tested positive for PfHRP-2 antigens by ELISA on blood specimens, and 32 were positive in saliva. PfHRP-2 antigens were not found in all the negative controls. Saliva can be used as a specimen for the detection of PfHRP-2 antigen. Development of detection methods necessary for the saliva specimens useful for malaria diagnosis.
Shelf Life Evaluation of Fortified Soynut-Chikki using Different Packaging Materials
Authors: Othzes Nilza , Khodke S. U.
Published: March 2024

Fortified soynut-chikki was developed using de-oiled groundnut meal and puffed soynuts as one of the main ingredients to explore its nutritional benefits. Prepared Fortified soynut-chikki was stored in two different packaging materials viz., PP (Polypropylene) and MP (Metalized polypropylene) packs to analyze the storability of fortified soynut-chikki at ambient condition (28±2°C). The microbial load, sensory characteristics (Overall acceptability scores), physico-chemical properties viz., moisture content, water activity, FFA (Free Fatty Acid) values, color (L* values) and hardness of fortified soynut-chikki following each packaging materials such as (PP and MP) pack were also evaluated during storage period of 135 days at a frequency of 15 days at ambient condition. Metalized polyester (MP) pack was found to be most effective packaging material for better storability of fortified soynut-chikki having shelf life up to 120 days at ambient condition (28± 2°C).