bluuebunny/crossref_metadata_2025 huggingface dataset:
RELIMINARY DETERMINATION OF THE COMPOSITION OF METAL PRODUCTS FROM THE ARCHAEOLOGICAL COLLECTION OF THE KURCHUM VILLAGE MUSEUM (EAST KAZAKHSTAN)
Authors: A. TISHKIN , G. OMAROV
Published: December 2023

The museum of the Kurchum village, the East Kazakhstan region of the Republic of Kazakhstan, exhibits a small collection of archaeological items which are mostly random finds. Among them stands out a group of items made of non-ferrous metal of various preservation. The studies were carried out with the use of a portable X-ray fluorescence spectrometer “INNOV-X SYSTEMS” ALPHA SERIES™ (model Alpha-2000, made in the USA). The surface of the attached exhibits covered with oxides and patina was tested. The results obtained can be considered as preliminary and demonstrating only qualitative indicators. However, these data make it possible to characterize the alloys used for the manufacture of various categories of objects of material culture.
FRAGMENTS OF METAL CAULDRONS FROM THE FOREST-STEPPE ALTAI AREA
Authors: Ya. FROLOV , A. Tishkin
Published: December 2023

In the course of planned surveys of archaeological sites in the Forest-Steppe Altai at different times fragments of metal cauldrons were found. There are also among accidental finds. It is often difficult to determine the dating and cultural belonging of such objects. Therefore, little attention is paid to them. However, such finds have their own information potential and a certain archaeological context. In the course of data collection for the formation of a database on metal cauldrons found in the mountains and in the forest-steppe zone of Altai, the authors of the article attract the found fragments of such items, which should be introduced into the scientific circulation. Four fragments are presented in this publication. The results of X-ray fluorescence analysis are given, which allow cultural and chronological identification of the finds.
ABOUT THE PURPOSE OF IRMEN STONE HAND MILLS
Authors: S. KOVALEVSKY
Published: December 2023

The article is devoted to such a category of stone tools of the Irmen cultural and historical community of the south of Western Siberia as hand mills or grain grinders. We have tried to summarize the information about the finds of such products in the Irmen settlements and funeral and memorial sites. It was found out that they are represented by two varieties: classic oval or rectangular grain grinders and round-shaped millstones. Special attention in the conducted research is paid to the context of finding grain mills within settlements and burial mounds. It is shown that grain grinders in some cases were placed in specially designated places, obviously playing a certain role in ritual practice.
CENSERS OF THE EARLY BRONZE AGE FROM THE ALTAI MOUNTAINS
Authors: N. Stepanova
Published: December 2023

Incense burners belong to the category of rare finds. They were found in the burials of the Afanasievo culture, Kurotinsky and Pokrovsky types, less often in ritual constructions. Similar items were found in several settlements. Comparative analysis showed that the main differences relate to the design of the pallet (legs). Kurotinskiye differ from the afanasievskiye ones in the absence of handles and, as a rule, are not ornamented. Altai Afanasievo products are less diverse in the design of the pallet compared to the Yenisei ones. They also differ from the Okunevsky ones in the design of the pallet and the presence of handles. They also differ from similar products of ancient pit and catacomb cultures. In general, Afanasievo incense burners are characterized by trays with a recess, less often flat, and handles-ears.
RARE TYPES OF GONUR DEPE BURIAL CONSTRUCTIONS: AN EXCEPTION OF THE RULES OR THE DEVELOPMENT OF THE TRADITION?
Authors: A. FRIBUS , N. DUBOVA , C. HUT , V. KUFTERIN , O. SYCHEVA
Published: December 2023

The main types of burial constructions at Gonur Depe site (2300-1500 BC) are represented by the following variants: shaft tombs, ordinary pit graves, chambers and cists. The revision of materials from the Large Necropolis and local necropolises allows depicting a more detailed typology and redefine the dataset. As a result, it is possible to describe a series of rare graves with atypical constructions. Their appearance is not the development of the BMAC burial rituals in chronological aspect, which is confirmed by the analysis of grave goods and the available 14C dataset. More likely, this is related to the local characteristics of micro groups that left burial complexes on the periphery of Gonur North and satellite settlements.
JEWELRY FROM THE EARLY MEDIEVAL SITE SROSTKI-I
Authors: X. BOYARINTSEVA
Published: December 2023

The article contains the information about the identification of the presence of jewelry based on the results of excavations of the mound group Srostki-I of different years. The materials of the expeditions of 1925, 1930, 2012-2014, 2016, which were carried out under the leadership of M.D. Kopytov, archaeologists M.N. Komarova, S.M. Sergeev, V.V. Gorbunov, are considered. Quantitative information is given in accordance with the types of products, groups are formed by the place of wearing jewelry. The use of non-ferrous metals and glass is noted as the main materials of manufacture, there are also inserts of stones. The most common products include jewelry belt set. The analysis was carried out on the basis of published materials and is the basis for further work with museum collections.
EXCAVATIONS OF NEW BURIAL MOUNDS OF THE XIANBEI PERIOD IN NORTHERN MONGOLIA: THE BURIAL COMPLEX AT MOUNT GAVILUY IN KHONGOR SUM OF DARKHAN-UUL AIMAG
Authors: T. IDERKHANGAI
Published: December 2023

Since 2010, the author has conducted research to find the political center of the Xiongnu empiricism, concentrated in the valleys of the Orkhon, Tamir, Hanui and Hunnui rivers in the central region of Mongolia. In 2018-2022 these studies were continued in the valleys of the Orkhon and Selenge rivers in northern Mongolia, and archaeological surveys and excavations were organized annually. As a result of this research, more than 10000 burial mounds of the Xiongnu time and elite burial complexes of the Xianbei time were discovered from 540 sites. The article, in addition to the results of the excavation of the mound of the Xianbei time, carried out in 2021 at the burial complex of Mount Gaviluy, Khongor somon of Darkhan-Uul aimag, presents the information about the third burial complex of the nobility of the Xianbei time, discovered in Mongolia, located near Mount Khongor ovoo in Baruunburen somon of Selenge aimag.
THE CULTURE OF NORTHERN QI (550-577) IN THE CONTEXT OF CROSS-CULTURAL CONTACTS IN THE EAST PART OF EURASIA (BASED ON THE MATERIALS FROM ELITE FUNERAL COMPLEXES)
Authors: M. KUDINOVA , S. KOMISSAROV , A. SOLOVIEV
Published: December 2023

The article examines materials of the burial complexes belonging to representatives of the highest aristocracy of Northern Qi (550-577). The design, burial inventory, plots and style of wall paintings in these burials are uniform, which indicates the strict regulation of the funeral rites. All the materials reflect the polyethnicity of the Chinese-Xianbi population of the Northern Qi (and in particular, the elites) and its intensive external contacts (with Turks, Rouran, Sogdians). The art presented in the tombs discussed demonstrates a fusion of ideas and images, originated from the Hun tradition and formed under the influence of Buddhism, as well as borrowed during the contacts with steppe nomads and the settled population of Central Asia.
STONE ALTARS OF THE EARLY IRON AGE AT THE OB-IRTYSH INTERFLUVE
Authors: K. MARGARYAN
Published: December 2023

The paper concerns 130 stone altars of the Early Iron Age from the Baraba Lowland, Kulunda Steppe and Upper Ob area. The earliest complexes with the regarded objects are situated in the Baraba lowland and are dated to the transitional period. The largest group of altars comes from the Upper Ob region and consists of 94 items. Based on the classification and typology of stone altars and comparison with nearby regions, the article concludes that the population of Central and Northern Kazakhstan migrated in the seventh-sixth centuries BC to the Upper Ob. Most likely in the 6th-5th centuries BC migration, most likely was from the territory of the Southern Urals to the Upper Ob region conclusion is made based on distribution of altars of rectangular and subrectangular shape with rounded corners on three and four legs. The region where such items are widely distributed is the South Urals.
THE "KURGAN WITH A “MOUSTACHE”" TROITSKOE-1 FROM THE NORTHERN KULUNDA STEPPE
Authors: Zh. MARCHENKO , A. GRISHIN
Published: December 2023

Here we present information about new ritual complex of ancient steppe nomads the «kurgans with a “moustache”» type. The paper presents the main characteristics of such structures from the Kazakh-South Ural area - the main place of their localization and lists the main historiographic issues related to their study. The Troitskoye-1 object discovered by the authors is in the northern part of the Kulunda steppe, originally identified by analyzing satellite images. The article describes the landscape situation, the structure of the complex, morphological features, and dimensions of the main elements of the site. The floodplain location of the complex, as well as a number of other similar objects in Northern Kulund, explains, in the authors' opinion, their relatively late archaeological fixation.
BOWS OF THE POPULATION OF THE LOWER ANGARA REGION IN THE FINAL OF THE EARLY IRON AGE
Authors: P. SENOTRUSOVA
Published: December 2023

Seven end plates for a bow made of horn were found at the Pinchuga-6 burial ground. This necropolis is dated to the 3rd-4th centuries AD. This is the largest fully studied burial ground of the end of the Early Iron Age in the valley of the lower reaches of the Angara. All overlays were divided into two types. The first type is represented by flat overlays with a cutout for a bowstring, which were attached in pairs to the ends of the bow. The second type is rectangular plates with a deep groove into which a wooden backing bow was inserted. On the Angara, such plates began to be made as the Late Bronze Age and continued to be used throughout the Early Iron Age and the Middle Ages.
HOLBO-4 — A NEW OBJECT OF THE YELGINSKY TIME OF THE BAIKAL REGION
Authors: A. Kharinskii , M. Portniagin , G. Ivanov
Published: December 2023

The archaeological site Kholbo-4 is located in the Olkhonsky district of the Irkutsk region, 1.2 km southeast of the village of Shara-Togot. In 2022, a trench measuring 1×8 m was excavated on it. From the east, the trench intersected a stone structure resembling an oval measuring 21×24 m, elongated along the north-south line. It consisted of stones laid in 1 row and 1 layer. All the finds found in the trench are confined to a layer of gray sandy loam (depth 4–28 cm from the surface of the earth). They are represented by fragments of pottery, whole and fragmented animal bones, iron slags. Ceramic vessels are smooth-walled, flat-bottomed, made without the use of a potter’s wheel. Among the ornaments decorating the vessels, horizontal bolsters and incised curvilinear ornament prevail. The archaeological site of Kholbo-4 can be attributed to the Yelga stage in the history of the Baikal region and dated within the 3rd century BC — 4th century AD.
PALEOECOLOGY OF THE UPPER STREAM OF THE OB RIVER IN THE EARLY IRON AGE ON THE EXAMPLE OF THE KAMENSKAYA ARCHAEOLOGICAL CULTURE
Authors: T. BLYAKHARCHUK , T. ZHILINA , M. RYKUN
Published: December 2023

The paper presents a reconstruction of changes in paleoecological conditions during the existence of the Kamenkaya archaeological culture from 2500 to 2000 cal. years in the south of Western Siberia based on pollen data biome modeling from 4 lacustrine-marsh sediments and on published geochemical data of Bolshoye Yarovoe Lake and Dolgonkoe Bog sediments. The analysis showed that the trend of gradual climate aridization by the end of the existence of this culture was regional and manifested itself to varying degrees in arid and more humid areas. In the steppe regions and in the mountains, the aridization of the climate was accompanied by winter cooling and an increase in the continentality of the climate. To a lesser extent, the climate drying affected the flat areas of subtaiga zone of Western Siberia, where either there were no noticeable changes, or, on the contrary, the climate was humidified, as noted earlier in publications.
TERRITORIAL GROUPS OF THE SITES OF THE ENEOLITHIC-EARLY BRONZE OF THE ALTAI MOUNTAINS AND THE AFANASIEVO CULTURE SETTLEMENT IN CONNECTION WITH THE PARTICULAR FEATURES OF THE ECONOMY
Authors: G. KRAVCHENKO , K. SOLODOVNIKOV
Published: December 2023

The authors investigates the connection between the uneven allocation of the sites of the Afanasievo archaeological culture in the Altai Mountains region and the system of their economic activity. A wide variety of the local climatic conditions is a characteristic feature for the region. The mapping of the archaeological monuments within the local climatic zones led to the conclusion: the inhabitants chose the areas with the possibility of all-year-round pasture for sheep for settlement. Sheep farming was the base of the economic activity. There were a lot of requirements for all-year-round pastures. Some areas satisfied the requirements, but they had harsh climatic characteristics for human inhabitation.
DEVELOPMENT OF A DATABASE ON DAGGERS DEPICTED ON THE “DEER” STONES OF INNER ASIA
Authors: O. LIKHACHEVA
Published: December 2023

The article presents the results of the development of a database designed to systematize images of shortbladed weapons stamped on “deer” stones. The database is a table in Microsoft Office Excel 2010 format and is designed to solve a number of tasks related to the study of the culture of the early nomads of Inner Asia. A detailed analysis of the table is carried out and the necessity of the proposed structure is justified. In total, at the moment, the database contains information from more than 100 sculptures originating from the territory of the Mongolian People’s Republic. It continues to be regularly updated with new information. The examples demonstrate the possibilities offered by the proposed layout of the table: what information can be selected using the “filters” tool, and how it can be applied when studying the visual sources themselves and the military affairs of the ancient population of the region in question.
“DEER” STONES IN CENTRAL MONGOLIA: INFORMATION POTENTIAL (BASED ON THE MATERIALS OF THE PUBLISHED CATALOG)
Authors: P. ERDENEPUREV
Published: December 2023

The study of “deer” stones in Mongolia began in the late 19th century, and many research papers have already been published. In 2021, a three-volume illustrated catalog “The Сulture of Deer Stones of Mongolia and Neighboring Regions” was published, which contains information about 1318 ancient sculptures. Based on this publication, the author of this article prepared information about the “deer” stones located in the Khangai Mountains of Central Mongolia. Surveys are constantly conducted in this region, but special studies of ancient statues have not yet been done, so there are prospects for the discovery of new “deer” stones. In this article we will talk about the process of discovering and studying “deer” stones and provide new facts. This data analysis is important for our future research. There are 592 such statues recorded in Central Mongolia. New methods and documentation technologies will be utilized to study them in detail, which will significantly expand our knowledge of the ancient nomadic cultures of Inner Asia.
RESTORATION OF THE WOODEN SADDLE DETAILS FROM THE YALOMAN-II CEMETERY
Authors: N. VASILYEVA
Published: December 2023

The materials of the Yaloman-II burial ground, which was investigated by Dr. A.A. Tishkin in the early 2000s, are informatively significant and are of particular interest for study. There are conditions that have preserved rare wooden objects of the ancient nomads of Altai in the tombs of this burial ground. Such an object is also a saddle from tomb 1 of barrow 33. It has reached our days fragmented, but at the same time almost intact. Two panels of saddletree, pommel and cantle were preserved. The find was rather quickly introduced into scientific environment and raised several questions. Over time, the state of preservation of the saddle deteriorated and conservation and restoration work was required. This article is devoted to the process of this unique find conservation.
FRONTIER DOCUMENTATION OF THE NORTH-WEST OF THE HUN EMPIRE
Authors: E. GIRCHENKO
Published: December 2023

During the Western Hun period (206 BCE - 9 CE) in the Hexi corridor after the victory of the Hun army over the Xiongnu, four new prefectures were formed. The main source of information about these garrison towns are wooden slips - hanjian. There are more than 80,000 hanjian discovered within the modern Gansu province. These are lists of soldiers; accounting books of administrative and military tasks; finance calculations; records of the issuance of clothing, rations; documents of officials and imperial decrees, trade transactions, etc. Their translation and correlation with the main written sources make it possible to reconstruct the specifics of trade contacts with nomadic peoples, the peculiarities of administrative management and daily routine in northwest China at the turn of common era.
KAMENNY KLEVETS FROM THE LOKTEVSKY DISTRICT
Authors: G. IVANOV
Published: December 2023

The article is devoted to the analysis of a rather rare product of the Eneolithic era - the beginning of the Early Bronze Age - a stone pecker made of light gray quartzite sandstone with a drilled hole, found in the spring of 2000 by Maxim Vladimirovich Syusyukov, a resident of Novenkoye village of the Loktevsky district, in a plowed field and probably originating from an ancient burial ground or a settlement. A detailed description of the find is given, its typological and chronological affiliation is determined. The closest analogies from Northern Kazakhstan make it possible to date the gun to the end of the 4th - 3rd thousand BC, point to the Western connections of the Altai population that have already been repeatedly noted during this period and expand the available source base for the complex of weapons of the population of the Altai steppes in the Eneolithic era - the beginning of the early Bronze Age.
On the localization of xylanolytic enzymes in Prevotella Bryantii B14
Authors: MARINŠEK-LOGAR Romana , NEKREP Franc Viktor
Published: December 2023

Prevotella bryantii B14 is a strictly anaerobic, Gram-negative, polysaccharides-degrading ruminal bacterium. EDTA/sphaeroplasting and osmotic shock procedure were used in present work to localise endoxylanolytic, b -xylosidase and a -L-arabinofuranosidase activities of P. bryantii B14. Late exponential phase cells released most of the endoxylanolytic and CMC-ase activity by osmotic shock, showing the periplasmic location of both enzymatic activities, while b -xylosidase and a -L-arabinofuranosidase activities were recovered largely in membrane cell fraction. About 23 % of the total culture endoxylanase activity and about 30 % of the CMC-ase activity were found to be extracellular. No b -xylosidase and a -L-arabinofuranosidase activities were detected in culture supernatant of P. bryantii B14.
Notazioni neumatiche dei secoli XI–XII nella Biblioteca Capitolare di Verona : Riflessioni e spunti di ricerca - Figures
Authors: Cunego Giovanni
Published: December 2023

The Materiality of Chant Manuscripts is an innovative multi-author  project dealing with the complex interconnections between learning, writing and  performing chant in the Middle Ages. A number of different methodological  approaches have been employed, with the aim of beginning to understand the  phenomenon of chant transmission over a large geographical area, linking and  contrasting modern definitions of East and West. Thus, in spite of this wide  geographical spread, and the consequent variety of rites, languages and musical  styles involved, the common thread of parallels and similarities between various  chant repertoires arising from the need to fix oral repertories in a written  form, and the challenges involved in so doing, are what bring this wide variety  of repertoires and approaches together. It is the Editors’ hope that this  multi-centric, multi-disciplinary approach will encourage scholars working in  these areas to consider their work as part of a much larger geographical and  historical picture, and thus reveal to reader and listener more, and far richer,  patterns of connections and developments than might otherwise have been  suspected. 
A series expansion of a logarithmic expression and a decreasing property of the ratio of two logarithmic expressions containing cosine
Authors: Li Yan-Fang , Qi Feng
Published: December 2023

In this study, by virtue of a derivative formula for the ratio of two differentiable functions and with aid of a monotonicity rule, the authors expand a logarithmic expression involving the cosine function into the Maclaurin power series in terms of specific determinants and prove a decreasing property of the ratio of two logarithmic expressions containing the cosine function.
Design guidelines for sustainable utilization of agricultural appropriate technology: Enhancing human factors and user experience
Authors: Rahman Taufik , Yassierli  , Widyanti Ari
Published: December 2023

The utilization of appropriate technology (AT) has become the Indonesian government strategy to increase productivity of agricultural commodities due to its simplicity and cost-effectiveness. However, the current utilization of AT remains suboptimal mostly due to design deficiencies that insufficiently account for human factors and user experience. In response, the aim of this study is to establish comprehensive AT design guidelines for sustainable AT utilization, focused on agricultural processing machines. An intensive observation was initially conducted in a rural community in Indonesia, to summarize difficulties faced by AT users. Supported by an exhaustive review of literature, a total of 44 human factors related design criteria were defined. Subsequently, these criteria underwent rigorous validation through a questionnaire administered to 197 respondents, consisting of AT designers, experts, and users. Employing the framework of principal component analysis (PCA), novel dimensions of AT design criteria were suggested, encompassing safety and error prevention, functionality and economics, user-friendly, low physical effort, physical workspace compatibility, and perceptible information. To augment the insights gleaned from the PCA, a matrix of importance-performance analysis was created, affording a map of the relative significance and concurrent performance of the defined criteria. The implications of this study are further discussed.
Pietro Aretino e Luciano di Samosata. Paradosso e parrhesia tra parola e immagine
Authors: Fantappiè Irene
Published: December 2023

Pietro Aretino constantly flaunts his originality and uniqueness as a writer. This essay seeks to show that, on the contrary, his authorial figure arises from a rewriting and a ‘refiguring’ of Lucian, especially as far as the centrality of paradox and of parrhesia are concerned. The present study reinterprets or adduces hitherto ignored evidence (consisting of both textual and iconographic materials, such as portraits, marche editoriali, and medals) in order to reconstruct some key aspects of Aretino’s relationship to Lucian, thus questioning the traditional idea of the writer’s unfamiliarity with the processes of imitatio of antiquity. Aretino’s approach to Lucian is investigated on three different levels, i.e. the level of intertextuality, of themes and genres, and of authorship. Firstly, the analysis inspects how Aretino’s Dialogo was influenced by a specific collection of vernacular translations of Lucian (I dilettevoli dialogi, 1525). Furthermore, the essay unveils the close relationship between Dialogo and Lucian’s De parasito as a model of paradoxical eulogy, thereby showing that Aretino’s text not only reverses the structures of relevant literary genres (e.g. the Platonic dialogue) but also originates from a ‘positive’ imitation of other generic templates (such as the Lucianistic paradoxical encomium). Finally, new findings about the sources of Aretino’s motto veritas odium parit and of its iconography shed light on the way Aretino fashions himself as a parrhesiastes by reproducing and transforming – and therefore imitating – Lucian’s figura auctoris.
Theromancein Hispano-Jewish Communities (Tenth to Thirteenth Centuries)
Authors: Gutwirth Eleazar
Published: December 2023

Most studies on the languages of the Jews in the tenth to thirteenth centuries in the Iberian Peninsula concentrate on Arabic and Hebrew, leaving theromanceaside. It is the purpose of this article to reassess this. It does so by assembling and interpreting evidence of language usage at that time and place. In some cases, the evidence has been relatively known in an isolated manner but is analyzed differently here. In others it has been ignored or is too recent to have been taken into consideration. The conclusion is that the romance was far more central in that culture than imagined before.
Citación, relaciones textuales y tradicionalidad en el discurso preeconómico español
Authors: Orense María Méndez
Published: December 2023

An important part of an argumentative text is to anticipate the potential criticisms made by the opponent and refute them with new arguments. This paper focuses on the linguistic strategies used to fulfill this pragmatic requirement in a corpus formed by representative works of the emerging Spanish economic thought in the sixteenth, seventeenth, and eighteenth centuries. These texts, called in Spanish “arbitrios” and “proyectos”, form a new type of specialized discourse, which, placed at the service of the State, assumes the function of dealing with the phenomena that affect the economic system and proposes measures that guarantee its stability. Throughout the expositive sequences, the author introduces external voices to pretend doubts and objections and provide answers to them. Based on the studies on textual polyphony and the model of discourse relations, a diachronic analysis of this construction is conducted and patterns of linguistic traditionality are identified. The analysis leads to new data about the elaboration processes that took place in the non-literary high prose during the transit from the classical to the modern stages of the Spanish language.
Synthesis, X-ray diffraction, DFT, and molecular docking studies of isonicotinohydrazide derivative
Authors: Fatima Aysha , Siddiqui Nazia , Khanum Ghazala , Haq Nazrul , Butcher Ray J. , Srivastava Sanjay Kumar , Javed Saleem
Published: December 2023

The synthesized compound N′-benzylidene-isonicotinohydrazide (N-BINH), was experimentally characterized using XRD and distinguished by using experimental spectroscopic methods. DFT, B3LYP method along with 6-311++G(d,p) basis set were applied to determine the optimal molecular geometry and vibrational wave numbers. Gauge Independent Atomic Orbital (GIAO) method and DFT were used to calculate the chemical shifts for 13C and 1H NMR in chloroform solvent. MEP analysis reveals that the site with an oxygen atom is the most reactive part of the N-BINH molecule. Computed UV–visible spectrum in MeOH and gas phase was generated by using the TD-DFT technique. The investigation also looked at electron localization function properties. Hirshfeld analysis demonstrates the 3D intermolecular interactions of the crystal surface, while fingerprint plots were used to elucidate the 2D interactions. By calculating the electrophilicity index, it was theoretically shown that the titled molecule could be bioactive. Further, molecular docking analysis was used to investigate the biological activity of the N-BINH with four distinct receptors to assess the finest ligand–protein interactions and similarity to the dynamic constituent.
O cuidado do idoso com Alzheimer e a resiliência do cuidador informal
Authors: Da Silva Alex Ribeiro , Campos Amanda Ribeiro , Da Cruz Ícaro Gabriel Carvalho , Araújo Suelen Silva , Coelho Kellen Rosa , Oliveira Flávia de
Published: December 2023

Objetivo: compreender o cuidado com o idoso com a doença de Alzheimer e a resiliência do cuidador informal. Método: pesquisa qualitativa com 20 cuidadores de idosos realizada de agosto a dezembro de 2019 através de um roteiro sociodemográfico-econômico e questões norteadoras analisadas pela Análise de conteúdo e Teoria das Representações Sociais. Resultados: foi observada a complexidade, singularidade e dualidade de sentimentos no cuidado com o idoso com a doença de Alzheimer. Apesar dos cuidadores não compreenderem o significado de resiliência, existe o desenvolvimento de habilidades para o enfrentamento do cotidiano de cuidados. Conclusões: o cuidador convive com a ambivalência de sentimentos e experiências, de caráter semelhante ou oposto, que interferem inteiramente no cuidado prestado e que contribuem na construção do processo de resiliência deste cuidador informal familiar.
Caracterização dos sintomas na hospitalização de pacientes em cuidados paliativos
Authors: Barci Bianca , Barreiro Victoria Bertine , De Souza Ana Carolina , Villar Jéssica Caroline , Barbosa Ludimila Domingues , Vasconcelos Tauana Fernandes , Bolela Fabiana
Published: December 2023

Objetivo: avaliar presença e intensidade dos sinais e sintomas de pacientes em cuidados paliativos nos três primeiros dias de internação. Método: estudo observacional, com pacientes adultos e idosos. Foi utilizado questionário para a coleta dos dados sociodemográficos e clínicos e um instrumento validado para a avaliação dos sinais e sintomas. Resultados: dentre os 50 participantes, a maioria é mulher (56%) com idade média de 66,7 anos e escolaridade de 6,1 anos. A principal doença de base foi câncer de pulmão (12%). Apresentaram elevados níveis de cansaço, sonolência, falta de apetite, depressão e ansiedade no primeiro dia de internação. No decorrer dos três dias de observação houve melhora em relação ao cansaço e à depressão e uma piora da sonolência. Conclusão: a assistência paliativa possui potencial para contribuir com o adequado manejo dos sintomas ao longo da internação, o que pode influenciar positivamente a qualidade de vida dos pacientes.
Affection of Motor Network Regions by Tau Pathology Across the Alzheimer's Disease Spectrum
Authors: Bischof Gérard N. , Jaeger Elena , Giehl Kathrin , Hönig Merle C. ,   for the Alzheimer’s Disease Neuroimaging Initiative, Weiss Peter H. , Drzezga Alexander
Published: December 2023

Stereotypical isocortical tau protein pathology along the Braak stages has been described as an instigator of neurodegeneration in Alzheimer's disease (AD). Less is known about tau pathology in motor regions, although higher-order motor deficits such as praxis dysfunction are part of the clinical description. Here, we examined how tau pathology in cytoarchitectonically mapped regions of the primary and higher-order motor network in comparison to primary visual and sensory regions varies across the clinical spectrum of AD. We analyzed tau PET scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort in patients with mild cognitive impairment (MCI;N = 84) and dementia of the Alzheimer's disease type (DAD;N = 25). Additionally, an amyloid-negative sample of healthy older individuals (HC;N = 26) were included. Standard uptake ratio values (SUVRs) were extracted in native space from the left and the right hemispheres. A repeated measurement analysis of variance was conducted to assess the effect of diagnostic disease category on tau pathology in the individual motor regions, controlling for age. We observed that tau pathology varies as a function of diagnostic category in predominantly higher motor regions (i.e., supplementary motor area, superior parietal lobe, angular gyrus, and dorsal premotor cortex) compared to primary visual, sensory and motor regions. Indeed, tau in higher-order motor regions was significantly associated with decline in cognitive function. Together, these results expand our knowledge on the in vivo pattern of tau pathology in AD and suggest that higher motor regions are not spared from tau aggregation in the course of disease, potentially contributing to the symptomatic appearance of the disease.
Striatal Neurons Are Recruited Dynamically into Collective Representations of Self-Initiated and Learned Actions in Freely Moving Mice
Authors: Tiroshi Lior , Atamna Yara , Gilin Naomi , Berkowitz Noa , Goldberg Joshua A.
Published: December 2023

Striatal spiny projection neurons are hyperpolarized-at-rest (HaR) and driven to action potential threshold by a small number of powerful inputs—an input–output configuration that is detrimental to response reliability. Because the striatum is important for habitual behaviors and goal-directed learning, we conducted a microendoscopic imaging in freely moving mice that express a genetically encoded Ca2+indicator sparsely in striatal HaR neurons to evaluate their response reliability during self-initiated movements and operant conditioning. The sparse expression was critical for longitudinal studies of response reliability, and for studying correlations among HaR neurons while minimizing spurious correlations arising from contamination by the background signal. We found that HaR neurons are recruited dynamically into action representation, with distinct neuronal subsets being engaged in a moment-by-moment fashion. While individual neurons respond with little reliability, the population response remained stable across days. Moreover, we found evidence for the temporal coupling between neuronal subsets during conditioned (but not innate) behaviors.
CDK11 requires a critical activator SAP30BP to regulate pre‐mRNA splicing
Authors: Wang Changshou , Xu Lin , Du Chen , Yun Hao , Wang Keyun , Liu Hui , Ye Mingliang , Fan Jing , Zhou Yu , Cheng Hong
Published: December 2023

CDK11 is an emerging druggable target for cancer therapy due to its prevalent roles in phosphorylating critical transcription and splicing factors and in facilitating cell cycle progression in cancer cells. Like other cyclin‐dependent kinases, CDK11 requires its cognate cyclin, cyclin L1 or cyclin L2, for activation. However, little is known about how CDK11 activities might be modulated by other regulators. In this study, we show that CDK11 forms a tight complex with cyclins L1/L2 and SAP30BP, the latter of which is a poorly characterized factor. Acute degradation of SAP30BP mirrors that of CDK11 in causing widespread and strong defects in pre‐mRNA splicing. Furthermore, we demonstrate that SAP30BP facilitates CDK11 kinase activities in vitro and in vivo, through ensuring the stabilities and the assembly of cyclins L1/L2 with CDK11. Together, these findings uncover SAP30BP as a critical CDK11 activator that regulates global pre‐mRNA splicing.
Estimativa do perfil biológico pelo palato: estudo transversal em crânios secos
Authors: Bordoni Leonardo Santos , Paiva Alan Rodrigues de Almeida , Soares Andre Lucas Moni , Dornelas Raphael Resende , Athayde Thiago Botelho , Boson Victor Campos , Bordoni Polyanna Helena Coelho
Published: December 2023

A estimativa do sexo biológico (ESB), da idade (EI), da ancestralidade (EA) e da estatura são essenciais para a definição do perfil biológico (PB) de um corpo desconhecido. Os elementos de maior precisão técnica para o PB são os ossos do quadril, dos membros e do crânio. Como nem sempre todos estes ossos estão presentes e como muitos sofrem processos tafonômicos, é importante o estudo de partes mais resistentes, como o palato. Neste contexto, foi realizado um estudo transversal com características métricas e não métricas do palato de 130 crânios secos periciados no Instituto Médico Legal André Roquette (Polícia Civil do Estado de Minas Gerias). A maioria era do sexo masculino, com faixa etária predominante entre 30 e 59 anos e de ancestralidade asiática. Quase todas as medidas do palato foram significativamente maiores nos homens. As suturas palatinas apresentaram progressivamente maior grau de fechamento em relação a idade e a distância entre os postalverions apresentou correlação negativa com a idade. Esta medida, bem como a distância entre o forame incisivo e a espinha nasal posterior, e o grau de fechamento da sutura palatina mediana anterior, se associaram, de forma independente e significativa, com o sexo, permitindo a elaboração de um escore de predição. Não houve correlação de nenhum dos parâmetros avaliados com a ancestralidade ou com a estatura. Os dados deste estudo reforçam o papel do palato na ESB e da EI, mas indicam que este deve ser utilizado com cautela na definição do PB.
Aplicação da radiação infravermelha na identificação de adulterações em documentos: estudos de casos
Authors: Aparecida Buffoni de Campos Carneiro Lara
Published: December 2023

Este artigo reúne estudos de casos acerca da aplicação da radiação infravermelha como ferramenta assertiva na identificação de sinais de adulteração em documentos. Utilizaram-se nas análises aparelhamento óptico disponível no Núcleo de Perícias Criminalísticas de Ribeirão Preto, permitindo a observação dos materiais periciados tanto sob a luz visível, como sob a radiação eletromagnética na região do infravermelho (radiação infravermelha). O conjunto procedimental aplicado permitiu, em alguns casos, diferenciar tintas de canetas esferográficas que se mostravam idênticas sob luz visível.  Suas propriedades físico-químicas produziram, sob análise não destrutiva, distintos perfis ante a luminescência do infravermelho. Outros materiais, porém, demonstraram perfis de luminescência indistinguíveis. Nesses casos, o potencial da propriedade da absorção da radiação infravermelha na busca por características indicativas de adulteração de documentos foi demonstrado por meio da sua capacidade em revelar elementos grafoscópicos, tais como a pressão do traçado sobre o suporte.
Panorama dos crimes contra a fauna na Região Metropolitana do Recife-PE, Brasil
Authors: Melo Monteiro Lucas de , Vasconcelos de Moura Farias Filho Alexandre , Pereira da Silva Andreson , Lumack do Monte Barretto Mariana , Oliveira Andrea Alice Fonseca
Published: December 2023

Objetivou-se com este estudo analisar as ocorrências de crimes contra fauna na Região Metropolitana do Recife-PE, com base nas informações constantes nos Termos Circunstanciados de Ocorrência da Delegacia de Polícia do Meio Ambiente do estado de Pernambuco. Para tal, foram avaliadas 326 ocorrências e as variáveis analisadas consistiram em: casos por ano e município, quantidade e grupo de animais envolvidos, tipo de infração, sexo, faixa etária do infrator, além de ocorrências por bairros do município de Recife-PE com distribuição espacial destas. O número de ocorrências registradas relacionadas a crimes contra fauna na Região Metropolitana do Recife-PE vem gradualmente elevando-se. Os infratores são predominantemente homens entre 20-59 anos, cujas infrações se relacionam a maus-tratos, sendo as aves silvestres as maiores vítimas. Com base nos dados obtidos, propicia-se a abertura para discussões e ações direcionadas a educação ambiental e de proteção aos animais, bem como o norteamento de forma estratégica das ações policiais.
Pedagogical Support as an Improvement Strategy: A Bibliometric Review of The Literature in Scopus and Wos During 2018-2023
Authors: Vilchez-Valdivia Lizeth Paola , Cardoza-Sernaqué Manuel Antonio , Montenegro-Camacho Luis , Canchari-Preciado Miguel Ángel , Rivas-Mendoza Milagros Isabel , García-Ventura Cynthia Catherine
Published: December 2023

The objective of the present study was the analysis and quantification of the scientific literature by means of metrics in relation to the research consulted on pedagogical accompaniment as an improvement strategy, in the Scopus and WoS databases, in addition the period is delimited. Publication between 2018 and 2023. Based on a personalized bibliometric review methodology, where “pedagogical accompaniment” and “pedagogical accompaniment” were used as search words. Regarding the year with the greatest number of publications, it was 2022 (n=9); while the average number of citations per year the highest value was that of 2019; The keyword indicator showed that the most recurrent words in the study are: "pedagogical accompaniment", "teaching practice", "accompaniment of pupils' activities" and "professional development", the "Social Sciences Journals" and "Venezuelan Journal of Management" presented the largest scientific production related to the subject, each with 2 articles. Regarding the affiliation of the authors, in the Scopus articles it was the Central University of Ecuador (n=2); and in WoS the César Vallejo University/César Vallejo Private University (n=3); while the countries with the highest scientific production were Chile and Peru, each with 3 articles in the WoS database; The most frequent language of publication of the articles was English, both for Scopus and WoS, with 6 articles each; The thematic areas where the identified bibliography was located were three: arts and humanities, administration and business, and social sciences; Finally, the themes.
Multiclass Classifier Based on Binary Logistic Regressions Obtained According to the Principles of GMDH
Authors:   National Technical University of Ukraine “Ihor Sikorsky Kyiv Polytechnic Institute”, Radchenko Oleh V. , Pavlov Volodymyr A. ,   National Technical University of Ukraine “Ihor Sikorsky Kyiv Polytechnic Institute”, Horodetska Olena K. ,   National Technical University of Ukraine “Ihor Sikorsky Kyiv Polytechnic Institute”, Korniienko Galina A. ,   National Technical University of Ukraine “Ihor Sikorsky Kyiv Polytechnic Institute”
Published: December 2023

Introduction. The issue of accuracy improvement in classification tasks is always topical, and various approaches have been developed, applied in accordance with the peculiarities of the problem formulation and properties of the feature space. Among the most effective models, classifiers based on multiple logistic regressions have proved themselves. Purpose. The aim of the paper is to develop an algorithm for solving multiclassification problems on the basis of binary logistic models built by the stepwise multiple logistic regression algorithm of the Stepwise type, improved according to the principles of the method of group accounting of arguments. Methods. The paper proposes a modification of the stepwise algorithm for creating binary multivariate logistic regressions Stepwise, where it is proposed to optimize the algorithm parameters in accordance with the principles of the method of group consideration of arguments: significance levels by the logarithmic likelihood ratio test for inclusion and exclusion of model arguments. The choice of optimal parameters is realized in accordance with an external criterion that takes into account the balance of classification accuracy of training and test samples and the balance of class classification accuracy. Subsequently, the binary class models obtained by the one-versus-all principle are combined into a multiclass classifier that returns the answer according to the maximum likelihood of the class. The comparison of classification models obtained by the classical Stepwise algorithm and the one proposed in the robot is carried out on the medical data of the publicly available Internet resource Kaggle. Conclusion. The paper substantiates and demonstrates the advantages of classifiers based on logistic multivariate regressions optimized according to the principles of the method of group consideration of arguments relative to the classical version of the Stepwise algorithm. The effective application of the algorithm in solving multiclass classification problem is shown.
Time to Positive Blood and Cerebrospinal Fluid Cultures in Hypothermic Young Infants
Authors: Potisek Nicholas M. , Morrison John , St. Ville Madeleine Elise , Westphal Kathryn , Wood Julie K. , Lee Jennifer , Combs Monica D. , Berger Stephanie , Lee Clifton , Van Meurs Annalise , Halvorson Elizabeth E. ,   Hypothermic Young Infant Research Collaborative, Sharma Meenu , McCartor Saylor , Raffaele Jenny , Doraiswamy Vignesh
Published: December 2023

BACKGROUND AND OBJECTIVE

Hypothermia in young infants may be secondary to an invasive bacterial infection. No studies have explored culture time-to-positivity (TTP) in hypothermic infants. Our objective was to compare TTP of blood and cerebrospinal fluid (CSF) cultures between pathogenic and contaminant bacteria in hypothermic infants ≤90 days of age.

METHODS

Secondary analysis of a retrospective cohort of 9 children’s hospitals. Infants ≤90 days of age presenting to the emergency department or inpatient setting with hypothermia from September 1, 2017, to May 5, 2021, with positive blood or CSF cultures were included. Differences in continuous variables between pathogenic and contaminant organism groups were tested using a 2-sample t test and 95% confidence intervals for the mean differences reported.

RESULTS

Seventy-seven infants met inclusion criteria. Seventy-one blood cultures were positive, with 20 (28.2%) treated as pathogenic organisms. Five (50%) of 10 positive CSF cultures were treated as pathogenic. The median (interquartile range [IQR]) TTP for pathogenic blood cultures was 16.8 (IQR 12.7–19.2) hours compared with 26.11 (IQR 20.5–48.1) hours for contaminant organisms (P < .001). The median TTP for pathogenic organisms on CSF cultures was 34.3 (IQR 2.0–53.7) hours, compared with 58.1 (IQR 52–72) hours for contaminant CSF organisms (P < .186).

CONCLUSIONS

Our study is the first to compare the TTP of blood and CSF cultures between pathogenic and contaminant bacteria in hypothermic infants. All pathogenic bacteria in the blood grew within 36 hours. No difference in TTP of CSF cultures between pathogenic and contaminant bacteria was detected.
Ideologia de gênero em perspectiva genealógica
Authors: Ornelas Rosa Pablo , Zamboni Jésio , Buxton dos Reis Vieira Breno
Published: December 2023

O avanço de lutas em torno dos direitos sexuais e reprodutivos vem sendo tratado por diversos segmentos políticos e religiosos como uma ameaça às hierarquias tradicionais. Diante deste campo que envolve diferentes perspectivas conflitantes, o artigo apresentado propõe uma análise sobre o uso da noção de “ideologia de gênero” como elemento fundamental na ofensiva contra esses direitos. Para isso, o texto proposto será dividido em duas partes: na primeira, serão apresentados os seus antecedentes e sua posterior difusão; na segunda, será realizada uma análise genealógica acerca da literatura produzida por distintos autores que se reconhecem como conservadores, adotando uma postura reativa em relação aos estudos de gênero e sexualidade; e por fim, na terceira parte, mostraremos como essa premissa acerca da existência de uma natureza humana e sexual universalmente diferenciada entre homens e mulheres não se sustenta, tomando como referência distintas pesquisas sobre gênero e sexualidade publicadas nas últimas décadas.