bluuebunny/crossref_metadata_2025 huggingface dataset:
Peur de (se) souffrir, de (se) voir souffrir et de (se) faire souffrir Quand le moi se dépasse…
Authors: Ostermann Gérard , Lesœurs Guy
Published: November 2023

La peur de l’autre, de la nature, du destin, de soi-même, de (se) souffrir, de (se) voir souffrir et la peur de (se) faire souffrir entraînent l’angoisse d’abandon avec en filigrane l’effroi devant la mort. Notre société occidentale actuelle semble vouloir estomper ou même éviter les souffrances de tous ordres dont il faudrait se libérer à tout prix afin de pouvoir jouir sans crainte et sans contrainte dans un Eden factice d’où seraient exclus les souffreteux, les vieux, les malades et les déshérités. Il nous a semblé intéressant de questionner cette peur de souffrir en l’apposant, voire en l’opposant, au décentrement de soi-même sur le mode actif-passif, altruiste-égoïste et pronominal. L’effort de « se souffrir » pris dans le sens de « se supporter » est le prérequis à s’imposer avant de s’occuper de la souffrance de l’autre. C’est tout le sens de l’introspection préalable à toute intention psychothérapeutique et même à tout acte de soin. En effet, si l’on n’a pas accompli une introspection longue, ardue et sérieuse, le risque majeur et délétère est de projeter sur l’autre souffrant sa propre angoisse devant la vie et la mort, ce qui majorerait la souffrance collective.
Avantage d’Endocuff vision® deuxième génération dans le dépistage des polypes coliques en pratique courante : cohorte historique prospective comparative
Authors: Benkessou Bouchra , Canard Jean-Marc , Moussali Joseph , El Ouaer Lisa , Contou Jean-François , Godeberge Philippe , Amar Irène , Amaris Juan , Chollet Robert , Costil Vianna , Julien Pierre-Emile , Tarrerias Anne-Laure , Palazzo Laurent , Odinot Jean-Marie , Paucard Alexia
Published: November 2023

Objectif : Les taux de détection des polypes (TDP) et des adénomes (TDA) sont des indicateurs de qualité de la coloscopie et sont directement corrélés aux risques de cancer d’intervalle et de décès par le cancer du colon. Plus de la moitié des cancers d’intervalle serait liée à des lésions non détectées. Le but de cette étude est de déterminer si Endocuff vision® 2 nde génération (EVC) améliore la détection des adénomes et des polypes coliques dans la pratique courante. Méthodes : C’est une étude monocentrique non randomisée, en ouvert, comparant les données préexistantes de la coloscopie classique, obtenues dans la pratique courante de l’établissement dans la période du 1 er juin au 22 juillet 2017 (période rétrospective) sur 515 sujets sans EVC, et 521 patients avec le dispositif EVC du 18 octobre 2018 au 30 septembre 2019, après information et recueil du consentement (période prospective). Ces deux périodes ont été consécutives afin de limiter le biais de sélection. Le critère de jugement principal correspondait à la détection du taux d’adénomes, réalisée en coloscopie classique avec ou sans EVC sur des patients adultes. L’essai a été analysé par un test de comparaison de proportion entre les groupes pour données indépendantes sur le critère principal. Résultats : Le taux de détection d’au moins un adénome est augmenté avec le dispositif Endocuff® de 16,83 % à 21,11 % (P=0,036). Une meilleure préparation avec un score Boston = 9, améliore la détection des adénomes de 19,76 % à 26,68 % (P=0,003). Avec l’EVC, un temps de progression inférieur à 5 mn est préférable pour améliorer le taux de détection des adénomes (RR = 1,141 (1,130 to 1,752), P=0,0013), et un temps de retrait entre 6 et 10 mn (RR=1,449 (1,161 to 1,810, P=0,0027). Conclusion : L’utilisation du système Endocuff® améliore de façon significative la détection des adénomes pendant la coloscopie chez les patients ayant des antécédents personnels ou familiaux de polypes et de cancer et chez les patients ayant un BMI > à 30 ainsi que le temps de progression. Il est indispensable dans la détection des adénomes pendant la coloscopie. Il n’y a pas eu de complication associée [3, 5]. N°d’enregistrement de l’essai : NCT NCT03758872
« … Les revues, mais je n’ai rien à en dire ! »
Authors: Deutsch Michel , Duwa Jérôme
Published: November 2023

Contrairement à ce que le titre de cet entretien laisse entendre, Michel Deutsch a beaucoup à dire sur sa trajectoire de lecteur de revues ou de contributeur à des revues. Sa vie intellectuelle qui s’éveille au sein du gauchisme et sous le choc de Mai 68 est placée d’abord sous le signe d’organes militants d’obédience mao comme les Cahiers Marxistes Léninistes et les Cahiers pour l’Analyse . Le magazine allemand Konkret complète sa formation d’étudiant sensible aux approches de l’École de Francfort et confirme sa forte inclination pour les questions politiques et la lignée brechtienne qu’il réactive dans ses propres pièces de théâtre. C’est d’ailleurs à la revue Travail théâtral qu’il va donner ses premiers articles. Les rencontres et amitiés avec Philippe Lacoue-Labarthe ou Jean-Christophe Bailly l’orientent vers d’autres revues comme Première Livraison ou Aléa .
La success story des vidéastes
Authors: Caceres Judith
Published: November 2023

Plus qu’un lieu d’expression, la plateforme YouTube est devenue un lieu d’exposition permettant à certains créateurs de contenus de bénéficier d’une certaine notoriété, jusqu’à parfois être érigés au rang de « star ». Le cinéma ou la télévision ne sont plus les seuls à faire naître des stars : il faut désormais aussi compter avec YouTube . Cet article se propose d’interroger le succès de ces nouvelles vedettes issues du web. À partir du discours de la presse magazine, nous proposons une réflexion sur la notoriété des créateurs de contenus vidéo et de dessiner en creux l’image de ces nouvelles célébrités issues du web.
La Star Ac’ revue et corrigée par les réseaux socio-numériques ?
Authors: Alexis Lucie
Published: November 2023

Cet article aborde le retour à l’antenne de la Star Academy sur TF1, en 2022, et met au jour la manière dont la chaîne, la production et les candidats l’ont envisagé au regard des nouvelles modalités de constitution du genre télé-réalité qui s’actualise désormais systématiquement avec les réseaux socio-numériques. D’abord, la communication en amont de l’émission sur les médias sociaux s’est fortement construite par des modalités discursives visant à la patrimonialisation du programme et a consisté à rappeler la première vie de la Star Academy. Ensuite, la production a capitalisé sur l’« émission-marque » en reprenant une mécanique qui avait déjà fonctionné. Enfin, la participation des spectateurs via les réseaux socio-numériques constitue la véritable augmentation du programme.
Cost-Effectiveness Analysis of Light Adjustable Lens Compared to Monofocal Intraocular Lens in Cataract Surgery
Authors: Nishihara Taiki W. , Hu Jenny Q. , Buchholz Rhiannon D. , Murphy James D. , Afshari Natalie A.
Published: November 2023

Purpose:

To analyze the cost-effectiveness of the Light Adjustable Lens (LAL; RxSight) in comparison to a monofocal intraocular lens (IOL) for individuals undergoing cataract surgery in both eyes.

Methods:

A cost-effectiveness analysis was performed using a Markov model that simulated the patient outcomes and costs associated with undergoing cataract surgery with the LAL or monofocal IOL. Cost-effectiveness was determined using the incremental cost-effectiveness ratio (ICER), a measure that quantifies the incremental cost in dollars per quality-adjusted life year (QALY) gained. Treatments with the ICER below the willingness-to-pay threshold (WTP) of $50,000/QALY were considered cost-effective. The model was also evaluated for the impact of uncertainties in parameters using one-way sensitivity and probabilistic sensitivity analyses.

Results:

The cost-effectiveness analysis showed that the LAL is cost-effective compared to monofocal IOLs in patients undergoing cataract surgery, with ICERs of $9,792/QALY (health care perspective) and $10,072/QALY (societal perspective) both significantly below the WTP. The model was most sensitive to patient age, market cost of the LAL, and proportion of patients with residual astigmatism following cataract surgery. The probabilistic sensitivity analysis showed that cataract surgeries in patients starting at age 65 years were cost-effective in 94% of the simulations at a WTP of $50,000/QALY.

Conclusions:

From both health care and societal perspectives, the study shows cataract surgeries performed with the LAL are cost-effective when compared to those performed with a monofocal IOL. More studies are needed to compare the LAL to other premium lenses that also provide patients with excellent visual outcomes at a higher cost.

[
J Refract Surg
. 2023;39(11):777–782.]
Fixed point results for a new $ \alpha $-$ \theta $-Geraghty type contraction mapping in metric-like space via $ \mathcal{C}_\mathcal{G} $-simulation functions
Authors: Taqbibt Abdellah , Elomari M'hamed , Savatović Milica , Melliani Said , Radenović Stojan
Published: November 2023

This paper aims to introduce the new concept of an $ \alpha $-$ \theta $-Geraghty type contraction mapping using $ \mathcal{C}_{\mathcal{G}} $-simulation in a metric-like space. Additionally, through this type of contraction, we establish fixed point results that generalize several known fixed point results in the literature. We provide some examples as an application that proves the credibility of our results.
Using Experiential Learning to Elevate Black Voices
Authors: Seifert Nick
Published: November 2023

Students taking higher education humanities courses value hard skills to succeed post-graduation. The author, who serves as both managing editor and faculty advisor to Howard University's literary arts journal ‘The Amistad,' models how this can be achieved through the Experiential Learning Theory (ELT). By relating the core principles of ELT (concrete learning, reflective observation, abstract conceptualization, and active experimentation) to a creative writing course that workshops student writing and produces a literary arts journal, the author provides an analytical template for other HBCUs courses to follow or expand upon. The chapter also unpacks the importance of reworking the creative writing workshop to one more in-line with HBCU demographics and a stronger assessment on the choices which govern student's creative writing process(es). This chapter's purpose is not to persuade but help interested creative writing instructors start or consider ways to assist young Black writers, publish more diverse authors, and provide marketable skills to students.
Everything Is Content
Authors: Reid Amber Tiffany Abnet
Published: November 2023

This chapter explores content creation in relation to internet memes and the origin of the concept of memes as explained by Richard Dawkins' meme theory. It argues that as transmitters and replicators of cultural information memes, including social media content have the potential to serve as powerful and effective vehicles for disseminating cultural information and creating cultural spaces. For students, social media use is often a part of their daily routine and lifestyle with a focus on professional use. Using the case study of a first-year course at an HBCU, the chapter explores how the “everything is content” philosophy can be applied in instruction to curate a cultural classroom space, foster students' abilities to make connections between academic and social content and encourage students' critical thinking of their role in the creation and sharing of cultural through their social media use.
Exploring Candidates' Initial Images of Similar Figures
Authors: Davis C.E.
Published: November 2023

This article investigates preservice candidates' knowledge of similar figures while engaged in teacher-related mathematical tasks (TRMT) with the primary goal of developing a lesson plan on similar figures. This investigation was part of a larger study investigating candidate knowledge of what and how to teach proportional reasoning concepts while engaged in TRMT. The data collection and TRMT cycle included individual discussions and reflections, group planning and discussions, and group presentations. Individual candidates also wrote their teaching philosophies and math autobiographies, which were reviewed. While candidates appeared to grasp many of the aspects of the concept of similar figures and similarity, there was a lack of precision and strength in their representations. The knowledge base of the candidates in both mathematics and teaching varied. As the study progressed, candidates relied heavily on their subject matter knowledge to justify their images and ideas.
An Exploratory Study on Career Challenges of  Spa Therapists in Sri Lanka
Authors: Mahindarathna Kasun , Ratnayake Iraj
Published: November 2023

Spa in Sri Lanka provides a rejuvenating experience for anyone looking to unwind from the stresses of everyday life or find relief from the pain of a severe illness. Professional spa therapists play a significant role in the Sri Lankan spa industry. They should work in various settings, specialising in knowledge concerning specific client populations, and learn multiple massage and spa bodywork systems that approach the body and healing from new perspectives; therefore, many professional therapists face various challenges. This exploratory study aimed to explore career challenges faced by spa therapists in Sri Lanka. According to the survey, We were able to locate eight spa therapists working in an SLDTA-registered spa in Colombo, the capital of Sri Lanka. Purposive and snowball sampling methods were used together to find information-rich cases. The thematic analysis has been used to analyse the data. According to the findings, different types of inherent and extrinsic challenges exist. These challenges include social, guest-related, health-related, workplace-place-related, economic, and regulatory-related. In addition, we were able to capture the response of Spa therapists to those challenges. The implications of this research would help understand the typical career challenges of Spa therapists and help the vocational training sector and industry regulators to develop measures to advance career development and establish the reputation of the occupation of the Spa therapist in Sri Lanka.
Marketing of Hospitality and Tourism Services by Prasanna Kumar, McGraw Hill Education (India) Private Limited, (2016; Pages: 349)
Authors: De Silva W. V. , Rathnasiri M. S. H.
Published: November 2023

The tourism and hospitality industry has been evolving globally as the most attractive service sector, uncovering unlimited potentialities. The endless avenues have been fragmented into countless tiny streets, creating various professions and other miscellaneous livings and broadening this service sector's scope. Since the delivery of a hospitality service is composed of a higher portion of emotional aspects and more toward subjective decision-making, professionals in the hospitality sector require a sound knowledge of every sharp/sensitive corner of the tourism and hospitality sector. We can praise this book because we felt the necessity of a simple book that anyone can read and understand without too much technical jargon.Marketing of Hospitality and Tourism Services" by Prasanna Kumar is a comprehensive guide that delves into the intricate marketing world within the hospitality and tourism industry. As someone interested in this field, the book is a valuable resource, offering insights and strategies to benefit beginners and veteran professionals. This book is well-streamlined and organized into 15 uncomplicated chapters. The internal order of the chapters is very similar, from the meaning and definition of the particular concept and relevant content to practice questions. The reviewers applied the academic approach used by De Silva et al. (2023), De Silva and Hettiarachchi (2023), Gamage (2021), Iddagoda and Dewasiri (2021), Peiris et al. (2020), and Dewasiri and Samarasinghe (2019) in reviewing this valuable masterpiece.
Effect of Growing Media and Foliar Applications on Growth, Yield, and Shelf Life of Mustard (Brassica nigra L.) Microgreens
Authors: Weerakkody W. A. A. U. , Devasinghe D. A. U. D. , Wijayawardhana H. C. D. , Wickramasinghe W. M. D. M.
Published: November 2023

Microgreens are young vegetable greens picked after 7-21 days of seed sowing. The popularity of microgreens has increased in recent years due to short production cycles and the requirement of minimal space. Mustard (Brassica nigra) microgreens are popular but empirical evidence on the effect of growing media and foliar sprays on their growth, yield, and sensory attributes is low. The effects of growing media (coir dust, tissue papers, coir dust 1: compost 1) and foliar sprays (water, Albert’s solution 100 ppm, or Ca (NO3)2 100 ppm) on growth, yield, shelf life, and sensory properties of mustard microgreens were tested in a completely randomized design. Shoot fresh weight (4.21±0.04 g), shoot dry weight (0.73±0.03 g), and shoot height (7.3±0.05 cm), each for 100 shoots, was significantly greater in coir dust medium+Albert’s foliar spray treatment than the other treatments. The shelf life of refrigerator-stored samples (5°C ±1 for 4 days) was significantly greater than those stored at room temperature (27°C±1 for 2 days). The highest weight loss (83.86±1.12%) was obtained in tissue papers+foliar spray of water, stored under room temperature, and the lowest (31.96±1.66%) was reported in coir dust+Albert’s foliar spray under refrigerated conditions. The sensory evaluation indicated the highest preference for taste, odour, color, and overall acceptability of mustard microgreens cultivated in coir dust medium + Albert’s foliar spray. Thus, the mustard microgreens grown in a coir dust medium+Albert’s solution spray and preserved under refrigerated conditions lead to better production and consumer preference.
Haematological Parameters of Lactating Dairy Cows Fed with Total Mixed Ration (TMR) Briquettes
Authors: Karunanayaka R. H. W. M. , Nayananjalie W. A. D. , Kumari M. A. A. P. , Weerasingha W. V. V. R. , Adikari A. M. J. B. , Somasiri S. C.
Published: November 2023

The goal of this study was to explore the influence of haematological parameters of nursing dairy cows fed with Total Mixed Ration (TMR) briquettes. Nine, Jersey × Sahiwal crossbred dairy cows (Body weight = 275 ± 33 kg and parity = 3) were randomly assigned to three treatments in a Completely Randomized Design (CRD) with a 14-day adaptation period and a 21-day feeding trial. A mixture of Guinea grass (Megathyrsus maximus (Jacq.) B.K. Simon & S.W.L. Jacobs) and commercial cow feeds (CTL) which was the control diet and two TMR briquettes including a variety of air-dried forages with agro-industrial by-products (TMR1 and TMR2) were employed as treatments. Blood samples were taken from each cow at the end of the feeding trial and haematological parameters were measured. The blood was tested for total white blood cell count (neutrophils, lymphocytes, monocytes, eosinophils, and basophils), red blood cell count (haemoglobin and red blood cells), and platelet count by following standard laboratory guidelines. The haematological parameters were not significantly (p>0·05) different among the treatments. The total white blood cell count (× 109 L-1) was measured for CTL, TMR1, and TMR2 as 9.7 ± 1.37, 10.20 ± 1.37, and 10.60 ± 1.37 while the red blood cells (× 1012 L-1) were 5.88 ± 0.60, 6.35 ± 0.60, and 4.40 ± 0.60, respectively. The platelet count (× 109 L-1) were observed as 213.33 ± 36.74, 215.33 ± 36.74, and 226.67 ± 36.74 in cows fed with CTL, TMR1, and TMR2, respectively. The study found that shifting the diet to TMR has no impact on haematological indicators in lactating dairy cows.
Structural and functional connectivity of the whole brain and subnetworks in individuals with mild traumatic brain injury: predictors of patient prognosis
Authors: Huang Sihong , Han Jungong , Zheng Hairong , Li Mengjun , Huang Chuxin , Kui Xiaoyan , Liu Jun
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202407000-00035/figure1/v/2023-11-20T171125Z/r/image-tiff

Patients with mild traumatic brain injury have a diverse clinical presentation, and the underlying pathophysiology remains poorly understood. Magnetic resonance imaging is a non-invasive technique that has been widely utilized to investigate neurobiological markers after mild traumatic brain injury. This approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury. Graph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and function. However, most previous mild traumatic brain injury studies using graph theory have focused on specific populations, with limited exploration of simultaneous abnormalities in structural and functional connectivity. Given that mild traumatic brain injury is the most common type of traumatic brain injury encountered in clinical practice, further investigation of the patient characteristics and evolution of structural and functional connectivity is critical. In the present study, we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain injury. In this longitudinal study, we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 weeks of injury, as well as 36 healthy controls. Resting-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network analysis. In the acute phase, patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention network. More than 3 months of follow-up data revealed signs of recovery in structural and functional connectivity, as well as cognitive function, in 22 out of the 46 patients. Furthermore, better cognitive function was associated with more efficient networks. Finally, our data indicated that small-worldness in the acute stage could serve as a predictor of longitudinal changes in connectivity in patients with mild traumatic brain injury. These findings highlight the importance of integrating structural and functional connectivity in understanding the occurrence and evolution of mild traumatic brain injury. Additionally, exploratory analysis based on subnetworks could serve a predictive function in the prognosis of patients with mild traumatic brain injury.
Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis
Authors: Azzolini Federica , Dolcetti Ettore , Bruno Antonio , Rovella Valentina , Centonze Diego , Buttari Fabio
Published: November 2023

In multiple sclerosis, only immunomodulatory and immunosuppressive drugs are recognized as disease-modifying therapies. However, in recent years, several data from pre-clinical and clinical studies suggested a possible role of physical exercise as disease-modifying therapy in multiple sclerosis. Current evidence is sparse and often conflicting, and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully elucidated. Data, mainly derived from pre-clinical studies, suggest that exercise could enhance long-term potentiation and thus neuroplasticity, could reduce neuroinflammation and synaptopathy, and dampen astrogliosis and microgliosis. In humans, most trials focused on direct clinical and MRI outcomes, as investigating synaptic, neuroinflammatory, and pathological changes is not straightforward compared to animal models. The present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.
A Rare Cause of Encephalopathy Post Renal Transplant: BK Polyoma Virus Encephalitis
Authors: Jeemon Gladwin , Ganesh Kartik , Madavana V Vidya , Abraham M. Abi
Published: November 2023

BK polyoma virus (BKV) belongs to Polyomaviridae family. It is a double-stranded DNA virus. Only a few cases of BKV–associated neurological disease in renal transplant recipients have been reported. BKV related central nervous system (CNS) infection may often remain unrecognized in immunocompromised patients. Here, we are reporting a case of BKV encephalitis post renal transplantation for the awareness of all physicians regarding this entity.
A critical review of the history and practices of millets in India
Authors: Veerabadhran Vijayalakshmi , Palakuru Hema Raju , Pratap Goli Penchala , Rajeshwari Bommidi , Prasad Goli Penchala , Srikanth Narayanam , Acharya Rabinarayan
Published: November 2023

Millets have a long-standing history in India, and one can trace their cultivation and consumption to ancient times. This critical review aims to provide a comprehensive analysis of the history, practices, significance, and diverse applications of millets in India by drawing information from a range of ancient texts. Millets have played a crucial role in India's agriculture and dietary landscape for millennia. However, despite their historical importance, there has been a recent resurgence of interest in millets due to their potential health benefits, climate-resilient nature, and sustainable agricultural practices. The literature on millets is scattered across various historical texts such as Veda, Purana, and Samhita, making it imperative to consolidate this information systematically. The review of historical sources reveals a rich diversity of millets in India, with over 28 distinct species. These include Balbaja, Kangu, Priyangu, Shyamaka, Kodrava, Nivara, Yavanala, Gavedhuka, Chinaka, Uddalaka, Charuka, Chanaka, Venuyava, Varuka, Varaka, Varattika, Todaparani, Madhulika, Nandimukhi, Nala, Nali, Mukunda, Sarabeejam, Shimbira, Nartaka, Prashatika, Ragi, and Kuri. Historical texts provide insights into millet cultivation techniques, traditional practices, and their importance in Indian diets. The consolidation of historical knowledge about millets is essential for understanding their potential as a sustainable and nutritional food source. Further research is needed to explore the mechanistic aspects of their nutritional and ecological significance.
Plant growth-promoting rhizobacteria and millets: A sustainable solution for food security
Authors: Swamy Chidanandamurthy Thippeswamy
Published: November 2023

Millets are grain crops of high agronomical importance in dry and semi-arid areas of the world. They are nutrient-rich minor cereals, resistant to pests, diseases, salt, heat, and drought stress. During the large-scale millet cultivation, farmers continue to deal with issues including poor soil fertility, scarce water supplies, climate change, and low production. Plant growth-promoting rhizobacteria (PGPR) are very useful microbes; they colonize plant roots and promote plant growth and development. Furthermore, they improve the plant yield through a variety of activities, such as secretion of plant hormones and secondary metabolites, solubilization of nutrients, nitrogen fixation, and providing biotic and abiotic stress tolerance. In addition, PGPR increases the fresh weight, dry weight, root length, shoot length, chlorophyll content, proline content, and antioxidant activities, and decreases the malondialdehyde content as well as electrolyte leakage of millet seedlings. PGPR contributes to soil fertility by mineralizing organic matter, removing pollutants and pesticides, phytoextracting and detoxifying heavy metals, and mineralizing organic matter.
Efficacy of PD-1/PD-L1 inhibitors in advanced hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Peng Tzu-Rong , Yang Li-Jou , Wu Ta-Wei
Published: November 2023

ABSTRACT

Objectives:

This study aimed to investigate the efficacy and safety of programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in patients with advanced hepatocellular carcinoma (HCC).

Materials and Methods:

PubMed, EMBASE, and the Cochrane Library were searched for articles published until November 2022. Studies reporting the efficacy of PD-1/PD-L1 inhibitors in patients with advanced HCC were eligible for inclusion. The outcomes were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and ≥ Grade 3 treatment-related adverse events (TrAEs).

Results:

Fourteen trials with 4515 patients with HCC were included. Our results showed that treatment with PD-1/PD-L1 inhibitors was associated with better ORR and DCR than that with control (placebo or sorafenib or lenvatinib) (odds ratio [OR], 3.89; 95% confidence interval (CI), 2.55–5.95 and OR, 1.47; 95% CI, 1.11–1.95, respectively). The overall hazard ratio (HR) of PFS and OS were 0.66 (95% CI 0.56–0.78) and 0.65 (95% CI 0.55–0.77), respectively. In subgroup analysis, PD-1/PD-L1 inhibitor combination therapy had an advantage in terms of PFS (HR: 0.57 vs. 0.81) compared to that of PD-1/PD-L1 monotherapy. The incidence of grade 3–5 TrAEs was not significantly higher with PD-1/PD-L1 inhibitors than that with the control (OR, 1.12; 95% CI, 0.70–1.81). However, the combination of PD-1inhibitor with higher incidence of Grade 3–5 TrAEs (OR: 2.04, 95% CI 0.66–6.32) than the combination PD-L1 inhibitor (OR: 0.95, 95% CI 0.50–1.81).

Conclusion:

The combination of PD-1/PD-L1 inhibitors and targeted agents significantly improved the clinical outcomes in patients with advanced HCC. However, the incidence of Grade 3–5 TrAEs with PD-1 inhibitor combination therapy was higher than the combination PD-L1 inhibitor.
Symbolic group varieties and dual surjunctivity
Authors: Phung Xuan Kien
Published: November 2023

Let

G

be a group. Let

X

be an algebraic group over an algebraically closed field

K

. Denote by

A=X(K)

the set of rational points of

X

. We study algebraic group cellular automata

\tau \colon A^G \to A^G

whose local defining map is induced by a homomorphism of algebraic groups

X^M \to X

, where

M

is a finite memory. When

G

is sofic and

K

is uncountable, we show that if

\tau

is post-surjective, then it is weakly pre-injective. Our result extends the dual version of Gottschalk's conjecture for finite alphabets proposed by Capobianco, Kari, and Taati. When

G

is amenable, we prove that if

\tau

is surjective, then it is weakly pre-injective, and conversely, if

\tau

is pre-injective, then it is surjective. Hence, we obtain a complete answer to a question of Gromov on the Garden of Eden theorem in the case of algebraic group cellular automata.
Synodality, the Exercise of Authority, and Decision-making Processes: Who gets to Make the Decisions?
Authors: Okoye Agnes
Published: November 2023

A religious superior is one who through appointment or election assumed the responsibility of being God's representative to guide other members of the institute in their commitment to seek out and do the will of God. Hence, leadership or exercise of authority in a religious institute is a spiritual reality with social connotation. Ecclesiastical offices are established in stable manner for spiritual purposes (cf. can.145, 1). Exercise of authority within the religious domain is not a question of wielding power over other members but service, empowering others for a maximum utilization of their potentials and talents for their personal fulfil, and for the attainment of the goal of the institute for the glory of God. With the second Vatican Council, there is newness in the mode of exercise of authority and decision making in religious institute. This write up is an attempt to expatiate the novum in exercise of authority and process of decision making from the perspective of canonical legislation and in the light of the principles of the Synod on Synodality. Pope Francis initiated the Synod on Synodality in October 10, 2021 to end in October 23, 2023. With this Synod he is calling the Church to rediscover its deeply synodal nature. “This rediscovery of the synodal roots of the Church will involve a process of humbly learning together how God is calling us to be as the Church in the third millennium.” (Vademecum for the Synod on Synodality 2022). Exercise of authority also is to be done in a synodal way without however cancelling the role of religious superiors as guide of their brothers and sisters in seeking for and doing the will of God and achieving the purpose of their profession of the evangelical counsels of poverty, chastity and obedience which is the perfection of charity or union with God (cf. can. 573).
Analysis of the Science Literacy Profile of Students at State Junior High School
Authors: Ashari Sintha Eka , Rachmadiarti Fida , Herdyastuti Nuniek
Published: November 2023

Objective: This study aims to determine the achievement of scientific literacy skills of junior high school students in the competency aspect. The competency aspects measured in this study are the competence to explain scientific phenomena, interpret data and scientific evidence, and evaluate and design. Methods: The research was conducted using the test method. The data was collected using a competency aspect scientific literacy test using a multiple choice test of 20 items on the scientific literacy test. The sampling technique used stratified random sampling, amounting to 67 students. Data analysis techniques using quantitative descriptive. Results: Based on the research conducted by the results of data analysis, it was found that the scientific literacy aspect of students' competence was included in the low category, with an overall average of 55.15%. The aspects of scientific literacy competency measured in this study are explaining scientific phenomena, interpreting data and scientific evidence, and evaluating and designing. The results of each scientific literacy competency indicator are as follows: (1) students' ability to explain scientific phenomena, the average percentage only reaches the deficient category; (2) students' ability to interpret data and scientific evidence in the deficient category and (3) students' ability to evaluate and design in the deficient category. Novelty: This study reveals an urgent need to develop appropriate innovations, methods, and designs to improve students' science literacy, especially the learning models used. These findings encourage teachers to improve learning continuously.
Internalizing the Character Value of Caring for the Environment Through the Project to Strengthen the Profile of Pancasila Students in Elementary Schools
Authors: Puspitasari Rhindra , Budimansyah Dasim , Sapriya Sapriya , Rahmat Rahmat
Published: November 2023

Objective: Finding appropriate ways to internalize the character values ​​of caring for the environment in elementary schools through a project to strengthen the profile of Pancasila students in terms of civic behavior, skills, and attitude. Method: This research is mixed research with quasi-experiment, with a population of 500 students from 5 elementary schools and a sample of 128 students from 3 elementary schools. Results: The internalization of environmentally caring character values ​​carried out through the project to strengthen the Pancasila student profile in elementary school students is quite effective with the final score of the experimental class; Elementary School 1 Jampiroso scored 82.0% civic behavior, civic skill 80% and civic attitude 81.0%, while Elementary School 2 Jampiroso scored civic behavior 81.0%, civic skill 80.0% and civic attitude 80.0% and Elementary School Shekinah civic behavior 83.0%, civic skill 80.0% and civic attitude 82.0%. Novelty: This research is a study of further experimental development related to the development of civic behavior, skills, and attitudes in elementary schools
Education for Sustainable Development (ESD): Analysis of System Thinking Competencies of Primary School Learners
Authors: Azzahra Mia , Pramudiyanti Pramudiyanti , Rohman Fatkhur , Nurwahidin Muhammad
Published: November 2023

Objective: Sustainable Development Goals (SDGs) is a 2030 agenda comprised of 17 goals. One of these goals, the fourth, pertains to Quality Education and includes indicator 4.7, Education for Sustainable Development (ESD), as one of its achievements. The implementation of ESD in education targets the instillation of systems thinking competencies within learning objectives. Consequently, students are expected to possess systems thinking competencies as a direct outcome of the learning process. The purpose of the research is to find out how good the system thinking competence of students in elementary schools is. Method: This study employs descriptive quantitative methods, analyzing 15 tested items to assess system thinking competencies. The analysis of competency in system thinking involved 65 sixth-grade students at Elementary School 1 Sukaraja. Data collected was analyzed using the Rasch model via the Winstep application. Results: The analysis of the data obtained revealed a notably low interaction between the items and the student's responses, with Cronbach Alpha producing a logit of 0.34. This suggests that students have limited ability to engage with complex systems, as evidenced by the logit number of -0.8. Novelty: The development of systems thinking competency in elementary school students must be continually monitored and fostered as an essential aspect of applying ESD principles to real-life issues to ensure a sustainable future. This is based on an analysis of the data obtained regarding the long-term impact of such an approach on the students' problem-solving abilities.
Development of Flipbooks Based on Guided Inquiry Models to Train Science Process Skills of Junior High School Students on Temperature and Heat Materials
Authors: Awaliyah Masna , Widodo Wahono , Haryono Eko
Published: November 2023

Objective: This development aims to produce a flipbook-based guided inquiry learning model to train science process skills that are feasible in terms of validity, practicality, and effectiveness. Method: The type of research used is development research. The development model used is the 4D model (define, design, develop, and disseminate). The assessment instrument used in this study consisted of learning device validation sheets and science process skills tests. Results:  Based on the results of data analysis, it can be concluded that digital-based flipbooks obtain an average validation in the valid category. These results indicate that flipbooks can be used as learning media. Novelty: The novelty of this research is an inquiry-based feature on flipbooks about temperature and heat, which can train students' science process skills. In addition, the developed inquiry-based Flipbook is also a digital flipbook.
The Influence of Industrial Work Practice Experience-Career Information on Student Competence with Work Motivation as an Intervening Variable in Bachelor of Electrical Engineering Education Graduates
Authors: Achmad Fendi , Kholis Nur , Dianawati Roswina , Rahmatullah Daeng , Nugroho Yuli Sutoto , Uulaa Rizki Fitri Rahima
Published: November 2023

Objective: This research aims to analyze (1) the direct influence of industrial work practice experience on work motivation, (2) the direct influence of industrial work practice experience on competency, (3) the indirect influence of industrial work practice experience on work readiness through work motivation; (4) the direct influence of career information on work motivation; (5) the direct influence of career information on competency; (6) indirect influence of career information on competence through work motivation; and (7) the direct influence of work motivation on the competency of undergraduate Electrical Engineering Education students at the Faculty of Engineering. Method:  The quantitative approach used in this research is the path analysis model. The population in this study were all undergraduate students of Electrical Engineering Education at the Faculty of Engineering, with a total population of 194 graduate students. Results: This research concluded that (1) industrial work practice experience has a direct effect on work motivation by 16%; (2) industrial work practice experience has a direct effect on competency by 16.81%; (3) industrial work practice experience has an indirect effect on competence through work motivation of 1.25%; (4) career information has a direct effect on work motivation by 7.29%; and (5) career information has a direct effect on competency by 4.41%. Novelty: Internship experience has a direct influence on work motivation and competence. This means that the Department of Electrical Engineering is expected to properly monitor and evaluate the implementation of students' industrial work practices in industry. Monitoring can be done through monitoring instruments, which must be filled in by internal supervisors and external supervisors, with the hope of increasing the effectiveness of implementing industrial work practices. Apart from that, the industry is expected to be able to optimize the role of students during industrial work practices so that they gain knowledge and experience that influences work motivation and competence.
On sentinel method of one-phase Stefan problem
Authors: Lamya Merabti Nesrine , Batiha Iqbal M. , Rezzoug Imad , Ouannas Adel , Ouassaeif Taki-Eddine
Published: November 2023

This paper is interested in studying the one-phase Stefan problem. For this purpose, we use the nonlinear sentinel method, which relies typically on the approximate controllability and the Fanchel-Rockafellar duality of the minimization problem, to prove the existence and uniqueness of a solution to this problem. In particular, our research focuses on the application of the nonlinear sentinel method to the single-phase Stefan problem. This approach aids in identifying an unspecified boundary section within the domain undergoing a liquid-solid phase transition. We track the evolution of the temperature profile in the liquid-solid material and the corresponding movement of its interface over time. Eventually, the local convergence used for the iterative numerical scheme is demonstrated.
La visita de Fray Alonso Guerra O.P. a la sede vacante de Michoacán
Authors: Leal Lobón Manuel
Published: November 2023

Las visitas eclesiásticas eran un medio para contactar y conocer la realidad diocesana, sus problemas y sus éxitos. Sin embargo, a veces chocaban con delicados problemas provocados por los grandes periodos de sedes vacantes, durante los cuales los miembros del cabildo, los dueños del gobierno y la administración de la diócesis podían hacer y deshacer a su antojo. Por lo tanto, era lógico quetemieran al nuevo obispo e intentaran evitar su visita
Long‐Lasting Stabilization and Improvement of Dry Age‐Related Macular Degeneration by a High Oral Taurine Dose
Authors: Artigas Francesc
Published: November 2023

Purpose: To examine the therapeutic potential of the amino acid taurine in the non‐ neovascular or ∙dry” form of Age‐Related Macular Degeneration (AMD), one of the main causes of vision loss in the elderly, which still lacks effective treatments. Taurine is the most abundant amino acid in the retina and exerts trophic and neuroprotective actions in cellular and animal models. Likewise, a recent Science paper indicates that taurine deficiency is a driver of aging and that taurine supplementation may be an effective treatment for age‐related diseases.

Case Description: A dry AMD patient (F.A., male, 62‐yr old) presented a Snellen best corrected visual acuity of 0.15 on the Right Eye (RE) and 0.2 on the Left Eye (LE) in June 2013, together with central retina atrophy and reduction of central macular thickness to 144 µm (RE) and 159 µn (LE) (OCT analysis; Topcon 3D OCT1000). Oral taurine intake (600 mg t.i.d.) arrested macular degeneration over a 5.5‐yr period and moderately improved visual acuity and macular thickness after doubling the dose from 1.8 g/day to 3.6 g/day in December 2018. This improvement remained stable until last control visit in January 2023.

Conclusion: Taurine may have disease‐modifying properties in dry AMD at the dose used. The present observations add to existing literature to foster proof‐of‐concept clinical trials using a high oral dose of taurine for the treatment of AMD.
Peningkatan Partisipasi dan Penguasaan Vocabulary Siswa Kelas VII A SMP 1 Kabat Menggunakan Media Flashcard
Authors: Safitri Anggun Nirmala , Miunadiroh Anisatul , Astutik Indri
Published: November 2023

In the primary school level, English is no longer a compulsory subject to be taught. In some schools, English is only a local subject. As a result, when students enter secondary school, they have very little knowledge of the English language. This is also the case in SMP 1 Kabat. Students' knowledge of English vocabulary is very low. Therefore, teaching vocabulary becomes crucial because vocabulary mastery is the foundation of learning the other four English language competencies. This research aims to enhance the participation and vocabulary mastery of 7th-grade students at SMP 1 Kabat using Flashcards as a media. This study employs the Class Action Research (CAR) method, consisting of two cycles, each with four stages: planning, acting, observing, and reflecting. Collaborative action research (CAR) is conducted, meaning students work together with the English teacher. The researcher collects data using tests, observations, and questionnaires. To analyze the data, the researcher uses both quantitative and qualitative descriptive analysis. Based on the research conducted, it was found that the percentage of student participation in the learning process in cycles 1 and 2 was 76.67% and 86.67%, respectively. As for the learning outcomes in the first cycle, it was 57%, which did not meet the passing target. However, in the second cycle, there was an increase to 80%, surpassing the minimum target of ≥75%. Based on the results obtained from the research, it can be concluded that the use of Flashcards as a media is highly effective in improving the participation and vocabulary mastery of 7th-grade students at SMP 1 Kabat.
Penerapan Problem Based Learning dengan Menerapkan Teknik Windows Shopping untuk Meningkatkan Motivasi Belajar
Authors: Rachman M. Yusuf Yusa , Fatkurochman Henri , Juremi Mukhamad
Published: November 2023

Law No. 20 of 2003 defines education as a conscious and planned effort to create a learning environment that enables students to develop their spiritual, personality, intelligence, morals, and skills that are useful for themselves, society, the nation, and the state. Problem-Based Learning (PBL) is a teaching model that uses real-world problems as a context to teach critical thinking, problem-solving, and acquiring essential knowledge from the subject matter (Duch: Shoimin, 2014, p.30; Sudarman, 2005, p.69). PBL encourages students to learn actively and focus on applying knowledge in real situations. "Window shopping" is an activity in which students learn in groups to engage in discussions within their groups, and the results of these discussions are then shared with other groups. This means that students are not confined to their seats but are free to move around the classroom for discussions. This research was conducted in class XI-Science 4 at SMAN 2 Tanggul with 36 students, and questionnaires and surveys were used as instruments. In the first cycle, based on the observation results using a questionnaire, it was found that over 50% of the students had low learning motivation. Then, in the second cycle, the researcher applied the Window Shopping technique within the PBL syntax, and after this intervention, there was an improvement, with less than 50% of students having high learning motivation. In conclusion, implementing the Window Shopping technique within the PBL teaching model can enhance students' learning motivation.