bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of treatment of patients with systemic autoimmune diseases on the background of reactivation of persistent Epstein-Barr virus infection
Authors: Lishchuk-Yakymovych K.O. , Haiduchok I.H. , Ischeykin K.E. , Chopyak V.V.
Published: October 2021

The article presents the study of effectiveness of inosine pranobex (IP) in patients with systemic autoimmune diseases (SAD) on the background of reactivation of persistent Epstein-Barr (EBV) infection. Among 380 patients with SAD (systemic lupus erythematosus, systemic vasculitides, rheumatoid arthritis, psoriasis), in 144 patients (37.9%) the reactivation of persistent EBV infection was detected through virus DNA identification using polymerase chain reaction (PCR) in three biological matrices (blood, saliva, scraping from the lesion site). 48 patients were receiving inosine pranobex at a dose of 50 mg/kg per day for three months. Treatment efficacy was controlled by studying the levels of expression of miR-146а, miR-155, miR EBV (BART-13 and BART-15), TLR9, the quantity of lymphocytes populations and subpopulations. After treatment, PCR results showed a decrease in viral replication in 66.7% of cases. The use of IP contributed to a significant decrease in the level of IgM, IgG specific antibodies, an increase in the level of expression of anti-inflammatory miR-146a, a decrease in the level of expression of pro-inflammatory miR-155 which may signify the strengthening of antiviral control. The study data demonstrated the decrease in the expression of miR EBV (BART-13 and BART-15) and TLR9 on the immunocompetent cells that can also be attributed to the criteria for IP effectiveness. The effectiveness of IP was also proved by the stabilization of cell mechanisms, namely the tendency to normalizing T and B cell populations, decrease in the number of natural killer cells and activated cells (CD25+, CD3+ HLA DR+). On the other hand, the number of lymphocytes with suppressor activity (CD4+25+) remained significantly high mitigating autoimmune aggression. The results of the study show that the use of IP for treating the acute phase of EBV infection contributed to the decrease of repliсative activity of the virus; suppressing the aggressiveness of autoimmune reactions. The decrease in the expression of miR EBV (BART-13 and BART-15) can be recommended as a criterion for the IP effectiveness; the decrease in the expression of TLR9 on immunocompetent cells –as a criterion for suppressing autoimmune reactions.
Postcovid syndrome: regarding the risks of developing thrombotic complications in patients with ischemic limb lesions (clinical cases)
Authors: Vysochyna I.L. , Nikolaenko-Kamyshova T.P. , Biesiedin O.M.
Published: October 2021

The problem of postcovidal syndrome is currently relevant, since in the stabilization of vital functions, the processes of immunological inflammation with significant disorders of endothelium functions continue; this causes tissue ischemization, especially in the presence of changes at the level of microcirculation in patients with angiopathy and vasculopathy. It is noted that in COVID-19 comorbidity with hypertension, coronary heart disease, diabetes mellitus, systemic connective tissue diseases the risks, course, prognosis and development of vascular complications significantly increase. The severity of the inflammatory process and predicting the likelihood of complications is accompanied by changes in laboratory indicators, namely: in the general blood test – leukocytosis, an increase in the level of neitrophilic granulocytes, a decrease in the content of hemoglobin and platelets; in biochemical indicators – a decrease in the level of the general protein, an increase in the indicators of alaninetransferase, aspartaminotransferase, C-reactive protein, lactatdehydrogenase, ferritin; coagulation changes – increase in the level of fibrinogen, D-dimer, reduction of activated partial thromboplastic time. On the basis of the considered clinical cases, taking into account modern ideas about the peculiarities of the development of thrombotic complications in COVID-19 infection in patients with ischemic lesions of the extremities, the need to prescribe low molecular weight heparin  as a selection drug for the treatment of thrombophilic conditions has been proven. Detailed study of histological material is important for establishing changes at the level of microcirculation and ischemization of tissues, this will allow to develop algorithms for the treatment and prevention of complications. Solving these issues, not only in the presence of COVID-19, but also in any stressful cases, requires careful clarification of the mechanisms for the development of complications and a timely adequate integrated approach to treatment to improve and stabilize the condition of patients.
MPACT OF SHOCK WAVES IN INERT MEDIA ON THE OPERATIONAL RELIABILITY OF LOW-PRESSURE EARTH DAMS
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, ANDREEV E. V.
Published: October 2021

During the operation of pressure hydraulic structures, there is an objective need to ensure their safety and reliability. In the case of non-stationary loads on hydraulic structures, they can be either seriously damaged or destroyed. One of the non-stationary effects can be considered a directed explosion on the body of a hydraulic structure or in the immediate vicinity of it. At significant Mach numbers, the processes of excitation of the internal degrees of freedom of molecules, ionization and dissociation of gas molecules, and their recombination occur behind the shock wave front. The course of these processes is due to the almost tenfold compression of the gas at the time of the explosion and it’s heating relative to the room temperature of the order of 104 K. The use of approximate and numerical methods is a consequence of the difficulties associated with the need to solve nonlinear equations of gas dynamics, with the simultaneous use of relaxation equations and equations of chemical kinetics at the same time.
Development of internal control in the agricultural production management system
Authors: Klychova Guzaliya , Zakirova Alsu , Valiev Ayrat , Ziganshin Bulat
Published: October 2021

The monograph scientifically substantiates and formulates the conceptual provisions of internal control in the management system of agricultural production. Within the framework of the concept, the directions for the development of internal control of assets and liabilities of an agricultural organization are proposed, which consist in improving the methodological tools of internal control. The proposed recommendations will make it possible to systematize and summarize the information collected during the audit in order to provide it to the management of the organization in a timely manner for making effective management decisions. For researchers, practicing accountants of agricultural organizations, managers of various levels, heads of enterprises, teachers, doctoral students, postgraduates and masters, students of centers and advanced training courses.
Görme Engelliler için Akıllı Bileklik Tasarımının Değer Mühendisliği Yöntemi ile Maliyet Analizi
Authors: TOP Neslihan , ELDEM Yrd. Doç Dr. Cengiz , ERDEN Orhan , ŞAHİN İsmail
Published: October 2021

Ürün tasarımı sürecinde, üretim maliyetini ve satış fiyatını sistematik bir şeklide belirlemek amacıyla geleneksel maliyet belirleme yöntemlerine alternatif olarak hedef maliyetleme yöntemi kullanılmaktadır. Hedef maliyetleme, müşteri beklentilerine uygun olarak belirlenen temel ihtiyaç ve bileşenler değiştirilmeksizin kalite arttırmada etkisi olmayan faaliyetlerin elenerek maliyetin en aza indirilmesi uygulamalarını kapsamaktadır. Hedef maliyet ile müşteriler tarafından değerli görülen faaliyetlere ait maliyet tablolarının oluşturulması ve gerekli iyileştirme çalışmalarının yapılması değer mühendisliği uygulamaları kapsamındadır. Bu çalışmada, görme engelli bireylerin bağımsız olarak yer ve yön tayin edebilmesi için tasarlanan akıllı bileklik tasarımının hedef maliyet analizi, değer mühendisliği uygulamaları ile gerçekleştirilmiştir. Analiz sonucu elde edilen verilere göre ürüne ait bileşenlerin müşteri değerleri doğrultusunda elde edilen hedef maliyet sonuçları tartışılmıştır.
The Interval-Valued Spherical Fuzzy Based Methodology and its Application to Electric Car Selection
Authors: TEPE Serap
Published: October 2021

Imagining, thinking, producing, developing and changing what you produce are among the main traits that make human beings human. Human beings question their raison d’être, their life, the quality of their lives; in other words, they ask why and how. All these inquiries result in the production of information, a flow of the information produced, and sometimes a product. Today, in a world where production takes place at an unprecedented pace, one needs to possess the technology to keep up with developments. This is a dynamic capability and must be continuously developed to make it endure. Electric vehicles, a gift of technological developments of the world of today, are a combination of imagination, a needs assessment, and sustainable innovations. This study addressed the problem of electric car selection and included a case study involving six criteria and ten alternatives. The proposed decision model has integrated AHP and ELECTRE methods with interval-valued spherical fuzzy sets. The novelty of this study stems from evaluating the performance of electric cars using IVSF-AHP-ELECTRE and selecting accordingly for the first time. In this study, the level of importance of battery capacity, autonomous driving, charging network, price, efficiency and performance criteria were determined. A ranking was then made for the electric car alternatives based on these criteria.
Polimerik Linoleik Asit İçeren Graft Kopolimerlerin Atom Transfer Radikal Polimerizasyonu ve Kondenzasyon Reaksiyonu ile Sentezi ve Karakterizasyonu
Authors: ALLI Sema
Published: October 2021

Bu çalışmada, NPLina1-g-PCL-g-PSt üç bloklu graft kopolimerler Atom Transfer Radikal Polimerizasyonu (ATRP) ve kondenzasyon reaksiyonu kullanılarak bir basamakta tek kap (one-pot) yöntemiyle sentezlendi. Polimerik linoleik asit dietanolaminle reaksiyona sokularak hidroksillenmiş linoleik asit polimerleri (NPLina1, NPLina2 ve NPLina3) elde edilmiştir. ε-Kaprolakton'nun (ε-CL) kalay (II) 2-etilheksanoat katalizörü varlığında 110 °C'de halka açılma polimerizasyonuyla poli(ε-kaprolakton) (PCL) sentezlenip, ardından 2-bromopropiyonil bromür ile esterleşmesi sonucu bromlanmış poli(ε-kaprolakton) (PCL-Br) makro başlatıcısı hazırlandı. Tek kap yöntemiyle, stiren (St) monomerinin PCL-Br makro başlatıcısıyla CuCl/PMDETA sistemi varlığında [I]:[CuCl]:[PMDETA] = 1:1:3 mol oranları kullanılarak, 110 °C’de toluen içinde ATRP'si ile NPLina1’nın kondenzasyon reaksiyonu aynı anda gerçekleştirildi. Böylece, kontrollü molekül ağırlıklarına ve orta derecede dar polidispersitelere sahip graft kopolimerler elde edildi. Tek basamakta gerçekleşen polimerizasyon üzerine monomer konsantrasyonu, başlatıcı konsantrasyonu ve polimerizasyon süresi gibi temel parametreler incelendi. Elde edilen polimerler, proton nükleer manyetik rezonans (1H NMR), fourier dönüşümlü kızılötesi spektroskopisi (FTIR) ve jel geçirgenlik kromatografısi (GPC) teknikleri kullanılarak karakterize edildi.
O MITO DO MAL, JACK O ESTRIPADOR
Authors: Fernandes Geraldo
Published: October 2021

Este estudo objetivou verificar quais motivos influencia a análise dos fatos (crimes, criminoso ou criminosos e vitimas ) em comparativo com o mito e como pode auxiliar a esclarecer a verdadeira identidade de Jack o estripador na pesquisa bibliográfica.Bem como analisar os livros sobre Jack, o Estripador, apresentar que a identidade de Jack o estripador continuará sendo um grande mistério e que o mesmo tornou-se um mito, avaliar a vitimologia, comparar alguns dos suspeitos de acordo com as investigações e diversos autores, apresentar o perfil de Jack, o Estripador, constatar que por mais tenhamos provas, jamais poderemos ter a real identidade do assassino.Para tanto foi utilizado o método pesquisa bibliográfica, a partir da análise dos conteúdos apresentados foi possível perceber a importância em estudar o caso Jack, o Estripador para conhecer melhor seu modo de agir, suas vitimas e como sua identidade será um eterno mistério.Por meio de todo o estudo e das sugestões de leituras que estão na bibliografia é possível perceber que as teorias conspiratórias criadas entorno do assassino de Whitechapel foi o fator primordial para declarar sua mitificação.
MICROSERVICE ARCHITECTURE FOR BUILDING HIGH-AVAILABILITY DISTRIBUTED AUTOMATED COMPUTING SYSTEM IN A CLOUD INFRASTRUCTURE
Authors: Zolotariov Denis
Published: October 2021

The article is devoted to the research and development of a highly available distributed automated computing system by iterative algorithms based on the microservice architecture in a cloud infrastructure. The subject of the research is the practical foundations of building high-availability automated computing systems based on microservice architecture in a cloud-based distributed infrastructure. The purpose of the article is to develop and to substantiate practical recommendations for the formation of the infrastructure of a high-availability automated computing system based on the microservice architecture, the choice of its constituent elements and their components. The task of the work: to identify the necessary structural elements of a microservice automated computing system and to analyze the constituent components and functional load for each of them, set specific tasks for building each of them and justify the choice of tools for their creation. In the course of the research, methods of system analysis were used to decompose a complex system into elements and each element into functional components, and tools: information technologies Apache Kafka, Kafkacat, Wolfram Mathematica, nginx, Lumen, Telegram, Dropbox, and MySQL. As a result of the study, it was found that the system infrastructure should consist of: fault-tolerant interservice transport, a high-availability computing microservice, and communication microservices with end customers, which save or process the results. For each of them, recommendations are provided regarding the formation and selection of implementation tools. According to the recommendations, one variant of implementation of such system has been developed, the principles of its operation are shown and the results are presented. It has been proven that when using a Kafka queue it is efficient to publish batches of results rather than one at a time, which results to significant overhead on queue servers and data latency for its clients. Recommendations are given on the implementation of the CI/CD system to build a continuous cycle of adding and improving microservices. Conclusions. Practical foundations have been developed for the implementation of high availability distributed automated computing systems based on microservice architecture in a cloud infrastructure. The flexibility in processing the results of such a system is shown due to the possibility of adding microservices and using third-party analytical applications that support connection to the Kafka queue. The economic benefit of using the described system is shown. Future ways of its improvement are given.
MODELING OF INFORMATION TECHNOLOGY OF MATERIAL RESOURCES MANAGEMENT OF A CONSTRUCTION COMPANY
Authors: Novozhylova Maryna , Kramarenko Vladyslav , Chub Olga
Published: October 2021

The article's research subject is the information technology of construction company's material resources management. The work's purpose is to construct and implement tools for modeling construction company's material resources management information technology. The article solves the following tasks: determining the place of information technology of construction company's material resources management in the modern construction company's information ecosystem, defining the main components, and building a functional model of construction company's material resources management information technology, taking into account the shortcomings of existing models, сreation of the multicriteria optimization model of the considered information technology. The following methods are used: system analysis, structural analysis, mathematical modeling of complex systems and processes, multicriteria optimization. The following results were obtained: a structural analysis of the existing information ecosystem at the regional level construction company, the composition of which is agreed on the organizational structure elements of the enterprise and the stages of the construction life cycle; considered the functions of construction company's material resources management which are realized at various stages of a construction project life cycle; constructed the set-theoretical model of material resources management information technology; determined the functional characteristics of the considered information technology, offered the criteria of information technology efficiency according to the ITIL strategy; constructed the conceptual model of information technology of material resources management. Conclusions: for the first time, developed tools for modeling construction company's material resources management information technology, including a theoretical-multiple model of material resources management information technology; Offered the information technology's conceptual scheme which realizes specific information technology's functional characteristics. The built modeling strategy will provide an opportunity for further development and software implementation of the information technology.
SPECIFIC FEATURES OF USING THE FOURTH STAGE OF ACOUSTIC EXPERTISE FOR SPECIAL PURPOSE PREMISES
Authors: Poroshin Sergei , Usik Victoriya
Published: October 2021

The subject of the report is the methodology of carrying out an examination of the application for the purpose of establishing the optimal acoustic minds in the prevalence of attribution. The goal is to improve the quality of all stages of acoustic examination, taking into account the premises for which there are special requirements for the quality of the transmitted content or for which there are features in the formation of the sound field. Such a sequence of stages requires the solution of several tasks: determining the conditions for conducting research, taking into account the specifics of the premises and content; selection of hardware and software complex for research; determination of informative criteria for assessing the acoustics of a room, taking into account all its features; processing and analysis of the results obtained. The application of this approach to the stages of acoustic examination was considered on the example of a conference room, for which there were requirements for high quality speech content, a sound reinforcement system was already used in the hall, and there were features in the formation of a sound field. The authors in the article describe the solutions to all the tasks for the investigated room. The results obtained made it possible to analyze the objective characteristics of the sound field and identify the reasons for the low quality of speech content transmission not only in the acoustic calculation, but when using the existing sound reinforcement systems (electroacoustic calculation). Conclusions. The proposed sequence of the stages of acoustic examination makes it possible to identify "problem" places in the formation of the sound field and / or to determine possible solutions even before the stages of checking existing architectural and construction solutions and the development of technical specifications for the construction of enclosing surfaces and measures to create optimal acoustic conditions.
PERITONITE ESCLEROSANTE ENCAPSULANTE
Authors:   Hospital de Braga EPE, Lucas Marques Isabel , Rios Hugo , Carneiro Teresa , Luís Dina
Published: October 2021

Introdução: A Peritonite Esclerosante Encapsulante (PEE) é um processo inflamatório crônico que culmina em encapsulamento e quadros de obstrução intestinal de repetição. Por se tratar de uma entidade rara não é colocada como hipótese e, na maioria das vezes, o diagnóstico é intraoperatório. Relato do caso: O caso descrito pretende ilustrar um quadro de PEE idiopática, cujo tratamento cirúrgico foi efetivo na resolução dos sintomas do paciente.
HÉRNIA VESICO-INGUINAL: RELATO DE CASO
Authors:   ¹Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul, Maria Garcia Cardoso Anna
Published: October 2021

Introdução: Hérnia é definida como uma protrusão anormal de um órgão ou tecido por um defeito em suas paredes circundantes. Embora uma hérnia possa ocorrer em vários locais do corpo, esses defeitos mais comumente envolvem a parede abdominal. Hérnias na região inguinal geralmente contém o omento e o intestino delgado. Entretanto, raramente pode conter conteúdos incomuns, como apêndice, ovário, bexiga urinária, cólon sigmóide e ceco. A correção cirúrgica das hérnias abdominais está entre os três procedimentos mais realizados por cirurgiões nos Estados Unidos. Relato do caso: Paciente masculino, 49 anos, sobrepeso, previamente hígido, encaminhado ambulatorialmente por hérnia inguinal bilateral, sintomático à direita. Há cerca de 5 anos observou aparecimento de hérnia inguinal à direita, tendo dor desde então, com piora no último ano, quando refere ter iniciado também com diminuição de jato miccional. Tomografia Computadorizada evidenciou hérnias inguinais, mais volumosa à direita, observando-se neste lado herniação da bexiga urinária. Internou eletivamente para realizar herniorrafia inguino-escrotal à direita, tendo sido optada por técnica de Lichtenstein. Procedimento sem intercorrências. Evolução adequada no pós operatório, apresentando na revisão boa cicatrização de ferida operatória, melhora da dor e dos sintomas urinários. Discussão: A incidência de bexiga fazendo parte de uma hérnia inguinal, chamada por Lavine, em 1951, de "cistocele escrotal", é de 1-4%, ocorrendo com mais frequência em indivíduos com mais de 50 anos de idade com história de correção de hérnia inguinal. Em função da raridade desse diagnóstico, há uma certa dificuldade de encontrar dados recentes sobre esse tema.
TRATAMENTO CIRÚRGICO DA HIDRADENITE SUPURATIVA COM RETALHO DO MÚSCULO GRANDE DORSAL: SÉRIE DE CASOS E REVISÃO DA LITERATURA
Authors:   Centro Universitário São Camilo, Silva Ferreira Karin , Gouveia Ibeli Lucas , Cagnacci de Castro Alves Nathalia , Barão da Silva Diego , Bartolomei de Siqueira Corradi Matheus , Rossi Mocchetti Érica , Amantini Messias Bruno ,   Hospital Geral de Carapicuíba
Published: October 2021

Introdução: Hidradenite Supurativa (HS) é uma infecção bacteriana crônica e recorrente da pele e do tecido celular subcutâneo que se caracteriza pelo diagnóstico tardio e difícil tratamento. O tratamento inicial é clínico, sendo o tratamento cirúrgico indicado aos casos avançados e recidivantes. Os retalhos fasciocutâneos e musculocutâneos têm sua utilização crescente no tratamento da HS, porém, ainda não há consenso na literatura quanto à melhor técnica cirúrgica a ser utilizada. O objetivo desse estudo foi analisar os resultados funcionais e estéticos da utilização do retalho do músculo grande dorsal no tratamento cirúrgico da HS e revisar a literatura sobre o tema. Relato do caso: Descrevemos seis casos de HS tratados com ressecção cirúrgica da área axilar acometida e cobertura com retalho do músculo grande dorsal com a técnica poupadora de músculo. Foram analisados complicações pós-operatórias, recidiva, alteração de mobilidade do membro, tempo de doença e atraso no tratamento. Conclusão: O uso do retalho do músculo grande dorsal demonstrou-se seguro e chamou a atenção quanto ao bom resultado estético e funcional para os pacientes, sendo, portanto, uma possível opção para o tratamento da HS.
PENINGKATAN KEMAMPUAN BERHITUNG ANAK KELOMPOK B USIA 5-6 TAHUN MELALUI PERMAINAN TRADISIONAL BATUANG ANGKO
Authors: Adrita Adrita
Published: October 2021

Penelitian ini dilakukan untuk mendeskripsikan kemampuan berhitung melalui permainan tradisional batuang angko anak Kelompok B usia 5-6 tahun. Penelitian di TK Kuncup Mawar menggunakan Metode Penelitian Tindakan Kelas. Prosedur penelitian yang dilaksanakan terdiri dari perencanaan, tindakan, observasi dan juga refleksi. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi dan dokumentasi. Teknik analisis data yang di gunakan berupa analisis data kualitatif dan juga analisis data kuantitatif. Pada pelaksanaan pra-tindakan dilakukan untuk mengukur kemampuan berhitung anak diperoleh persentase sebesar 53.3%. Kemudian siklus I terjadi peningkatan sebesar 65.45% dan pada siklus II dilaksanakannya tindakan diperoleh peningkatan sebesar 85.84%. Dari hasil yang didapat terlihat permainan tradisional batuang angko mampu meningkatkan kemampuan berhitung anak. Dalam aspek anak mampu menyebutkan lambang bilangan 1-20, anak mampu membilang, anak mampu mengenal lambang bilangan, dan anak mampu mencocokkan bilangan dengan lambang bilangan.
ANALISIS PERKULIAHAN DARING PADA SEMESTER V PROGRAM STUDI PENDIDIKAN GURU PENDIDIKAN ANAK USIA DINI
Authors: Joni Joni , Alim Melvi Lesmana
Published: October 2021

Perubahan system perkuliahan dari tatap muka menjadi daring yang disebabkan munculnya wabah Covid-19, sedikit banyaknya telah membawa pengaruh cara belajar mahasiswa SI PG-PAUD. Tujuan penelitian ini adalah untuk mengetahui pendapat mahasiswa Semester V terhadap perkuliahan daring dan apa faktor pendukung dan penghambat yang dihadapi mahasiswa. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian field research, Adapun yang menjadi populasi yang peneliti ambil adalah mahasiswa semester V dengan teknik purposive sampling, sementara teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dolumentasi, model analisis data yang digunakan adalah model Miles dan Huberman yaitu dilakukan secara interaktif dan berlangsung secara terus menerus sampai tuntas, meliputi data reduction, data display, conclusion. Disimpulkan bahwa dalam pelaksanaan perkuliahan daring mahasiswa semester V terpecah menjadi 2 kubu pro dengan alasan lebih banyak waktu bisa mengerjakan pekerjaan lain adapun kubu kontra dengan alasan perkuliahan kurang efektif dan efesien, untuk kelebihan sepakat dengan perkuliahan dapat dilakukan dari rumah masing, dan kekurangan masih terkendala sinyal yang kurang bagus, untuk nilai (IPK) mayoritas meningkat dari IPK semester sebelumnya.
PENINGKATAN AKTIVITAS DAN HASIL BELAJAR SISWA DALAM PEMBELAJARAN IPS TERPADU DENGAN MODEL COOPERATIVE LEARNING TIPE TWO STAY TWO STRAYDI KELAS VII 1 MTsN 11 AGAM
Authors: Hayati Sri
Published: October 2021

Tujuan penelitian ini adalah mendeskripsikan Peningkatan aktivitas dan Hasil Belajar Siswa Dalam Pembelajaran IPS Dengan Menggunakan Model Cooperative Learning Tipe Two Stay Two Straydi Kelas VII 1 MTsN 11 Agam. Pendekatan penelitian yang digunakan adalah pendekatan kualitatif dan kuantitatif. Jenis penelitian yang dilakukan adalah penelitian tindakan kelas yang dilaksanakan dalam 2 siklus yang meliputi perencanaan, pelaksanaan, pengamatan dan refleksi. Subjek penelitian adalah siswa Kelas VII 1 MTsN 11 Agam yang berjumlah 32 orang. Data penelitian berupa hasil pengamatan dan hasil belajar siswa yang diperoleh melalui lembar observasi dan lembar tes. Hasil penelitian pengamatan RPP pada siklus I adalah 85,7 % (baik) meningkat menjadi 92,9% (sangat baik) pada siklus II. Hasil pengamatan aspek guru siswa pada siklus I adalah 76,56% (baik) meningkat menjadi 92,19% (sangat baik) pada siklus II. Hasil pengamatan aspek siswa siswa pada siklus I adalah 73,31% (cukup) meningkat menjadi 92,18% (sangat baik) pada siklus II. aktivitas belajar siswa pada siklus I 53,90 % meningkat menjadi 82,02 % pada siklus II. Hasil belajar siswa pada siklus I adalah 72,77 meningkat menjadi 81,99 pada siklus II. Dengan demikian dapat disimpulkan bahwa model Cooperative Learning Tipe Two Stay Two Straydapat meningkatkan aktivitas dan hasil belajar siswa pada pembelajaran IPS TERPADU di Kelas VII 1 MTsN 11 Agam.
PENINGKATAN KETERAMPILAN MOTORIK HALUS MELALUI KEGIATAN MENGGUNTING MEDIA DAUN Di KELAS A TK TUNAS HARAPAN KECAMATAN TAPUNG HILIR
Authors: Rastuti Rastuti , Zulfah Zulfah , Pahrul Yolanda
Published: October 2021

Penelitian ini bertujuan untuk meningkatkan motorik halus anak melalui kegiatan menggunting media daun di kelas A TK Tunas Harapan. Hal ini dilatar belakangi oleh rendahnya kemampuan Motorik Halus anak pada indikator menggunting lengkung. Penelitian ini merupakan penelitian tindakan kelas (PTK), instrumen yang digunakan lembar observasi yang berbentuk ceklis dan dokumentasi, waktu pelaksanaanya dari tanggal 12 April 2021 sampai 21 April 2021, subjek penelitian yakni 12 anak kelas A yang terdiri dari 6 anak laki-laki dan 6 anak perempuan dan di laksanakan dalam 2 siklus yakni siklus 1 dan siklus II. Pada tahap pratindakan persentase rata-rata ketercapaian anak baru mencapai 52.08%, Hasil penelitian Siklus I persentase yang dicapai sebesar 60,87%, dan pencapaian peningkatan keterampilan motorik halus anak pada Siklus II sebesar 84,95%. Kesimpulan penelitian melalui kegiatan mengguntig media daun dapat meningkatkan motorik halus anak di kelas A TK Tunas Harapan Tapung Hilir.
اسباب الديهل وحجم أضرارها في مدينة مندلي
Authors: أشعيل جرمط حدين
Published: October 2021

تعج الديؾل واحجة مؽ أىؼ الكؾارث الظبيعية التي تتعخض ليا مشاطق كثيخة مؽ دول العالؼ ومشظقة الجراسة بذكل خاص بيؽ الحيؽ واألخخ،عمى الخغؼ مؽ أنيا تقع ضسؽ حدام السشاطق شبو الجافةعالسيا،إذ أن طبيعة جيؾلؾجية السشظقة تتسيد بكثخة األودية الستخابظة التي يخجع تكؾيشيا الى العرؾر القجيسة،حيث تستج الدالل الجبمية فييا مؽ جية الذخق والذسال الذخقي مسا جعميا مشاطقجيجة لتجسع مياه األمظار،وحجوث عاىخة الديؾل الجارفة التي نتج عشيا الكثيخ مؽ األضخار السادية وندوح سكأن القخى الى السشاطق السجاورة ىخبا مؽ خظخ الديؾل السجمخة، ومؽ ىحا السشظمق تشاول البحث الحالي دراسة الديؾل وحجؼ األضخار الشاتجة عشيا في مجيشة مشجلي.
الحماية المدنية للبيئة المائية من التلوث
Authors: حسن محسن الجامعي علي
Published: October 2021

يتناول البحث مدى الحماية المدنية للبيئة المائية من التلوث من خلال التركيز على ماهية البيئة المائية ومفهوم التلوث المائي من خلال بيان معناه واسبابه ، وكذلك موقف التشريعات الداخلية ودورها في حماية البيئة المائية وبالخصوص موقف التشريعات المدنية والتشريعات الخاصة بحماية البيئة المائية من التلوث . وكذلك بيان اهم الوسائل والاجراءات اللازمة لمنع وقوع التلوث وكذلك الوسائل اللازمة للحد من هذا التلوث في حال وقوعه وما يسببه من أضرار جسيمة للكائنات الحية سواء للانسان أم للحيوانات والنباتات المائية ، وكذلك فرض الجزاءات المدنية عند تحقق هذه المسؤولية ، وفي الختام سنصل إلى مجموعة من النتائج والتي عسى أن تسهم في حل بعض المشكلات البيئية في نطاق القانوني المدني  .
IMUNISASI
Authors: S Indah.
Published: October 2021

Imunisasi adalah proses untuk membuat seseorang imun atau kebal terhadap suatu penyakit
marketplace analysis for e commerce
Authors: Noor Hilman ismi
Published: October 2021

At the point when Indonesia encountered a financial emergency, this condition affected huge scope organizations where numerous organizations had fallen and even failed. One more case with little and medium organizations where they can endure in light of the fact that they don't utilize many imported unrefined components and on second thought become a lifeline belt from the effect of the monetary emergency (Andalan and Hikmah, 2013)
МЕТОДИ АНАЛІЗУ НАУКОВИХ ПУБЛІКАЦІЙ
Authors: Piltyay Stepan
Published: October 2021

Запропоновано результати дослідження щодо наукових публікацій у різноманітних наукових журналах та базах.
ASI DAN MP-ASI
Authors: Astria Nurul
Published: October 2021

ASI merupakan cairan emas yang diracik oleh Yang Maha Sempurna dan tidak ada produk buatan manusia (susu formula ataupun sejenisnya) yang mampu menandinginya. ASI mengandung kurang lebih 500 jenis nutrisi dan susu formula hanya sekitar 40 jenis saja. ASI adalah susu yang diciptakan Tuhan khusus untuk bayi manusia. Susu formula yang dibuat dari susu sapi atau kedelai hanyalah dibuat menyerupai ASI dan iklan yang sebaliknya dapat menyesatkan. Akan tetapi karena gencarnya iklan-iklan di berbagai media target nasional 80% ASI eksklusif untuk mencapai MDGs 2015. Makanan Pendamping ASI (MP-ASI) adalah makanan atau minuman yang mengandung zat gizi, diberikan kepada bayi atau anak usia 6-24 bulan guna memenuhi kebutuhan gizi selain dari ASI. MP-ASI berupa makanan padat atau cair yang diberikan secara bertahap sesuai dengan usia dan kemampuan pencernaan bayi. Pada usia 6-24 bulan ASI hanya menyediakan 1/2 kebutuhan gizi bayi. Dan pada usia 12-24 bulan ASI menyediakan 1/3 dari kebutuhan gizinya. Sehingga MP-ASI harus diberikan pada saat bayi berusia 6 bulan (Kemenkes RI, 2014).
ASI DAN MP-ASI
Authors: rahmayanti
Published: October 2021

ASI merupakan cairan emas yang diracik oleh Yang Maha Sempurna dan tidak ada produk buatan manusia (susu formula ataupun sejenisnya) yang mampu menandinginya. ASI mengandung kurang lebih 500 jenis nutrisi dan susu formula hanya sekitar 40 jenis saja. ASI adalah susu yang diciptakan Tuhan khusus untuk bayi manusia. Susu formula yang dibuat dari susu sapi atau kedelai hanyalah dibuat menyerupai ASI dan iklan yang sebaliknya dapat menyesatkan. Akan tetapi karena gencarnya iklan-iklan di berbagai media target nasional 80% ASI eksklusif untuk mencapai MDGs 2015. Makanan Pendamping ASI (MP-ASI) adalah makanan atau minuman yang mengandung zat gizi, diberikan kepada bayi atau anak usia 6-24 bulan guna memenuhi kebutuhan gizi selain dari ASI. MP-ASI berupa makanan padat atau cair yang diberikan secara bertahap sesuai dengan usia dan kemampuan pencernaan bayi. Pada usia 6-24 bulan ASI hanya menyediakan 1/2 kebutuhan gizi bayi. Dan pada usia 12-24 bulan ASI menyediakan 1/3 dari kebutuhan gizinya. Sehingga MP-ASI harus diberikan pada saat bayi berusia 6 bulan (Kemenkes RI, 2014)
Gslc tut 2
Authors: Meyka Caroline
Published: October 2021

Selama pandemi Covid-19, banyak bisnis harus menghadapi persaingan yang ketat dan pertumbuhan yang melambat. Pandemi ini telah mempengaruhi semua industri di Indonesia, termasuk industri logistik, terutama organisasi pelabuhan. Gangguan dalam industri logistik ini mengakibatkan pengurangan beban kargo trailer dan kontainer. Hal ini dapat terjadi karena pembatasan transportasi karena perusahaan harus menerapkan keamanan kesehatan yang lebih besar. Akibatnya, ini mengganggu rantai pasokan dan menyebabkan penurunan volume kontainer di beberapa daerah. Cikarang Dry Port adalah perusahaan pengelola pelabuhan darat yang mulai beroperasi pada tahun 2010 dan ditetapkan sebagai Kawasan Pabean Terpadu dengan kode IDJBK.
Financial Power and Democratic Legitimacy: How To Think Realistically About Public Debt
Authors: Prinz Janosch , Rossi Enzo
Published: October 2021

To what extent are questions of sovereign debt a matter for political rather than scientific or moral adjudication? We answer that question by defending three claims. We argue that (i) moral and technocratic takes on sovereign debt tend to be ideological in a pejorative sense of the term, and that therefore (ii) sovereign debt should be politicised all the way down. We then show that this sort of politicisation need not boil down to the crude Realpolitik of debtor-creditor power relations—a conclusion that would leave no room for normative theory, among other problems. Rather, we argue that (iii) in a democratic context, a realist approach to politics centred on what Bernard Williams calls ‘The Basic Legitimation Demand’ affords a deliberative approach to the normative evaluation of public debt policy options.
Repo Man: a onda punk e Suburbia: o poder suave em filmes hollywoodianos
Authors: Vargas Herom , Ballerini Franthiesco
Published: October 2021

Os filmes de Hollywood são eficientes como poder suave, capazes de seduzir com ideias e valores. De outro lado, o movimento punk é caracterizado pela insubordinação e violência contra o sistema. Com base no conceito de poder suave e nos estudos culturais, este artigo discute duas obras de ficção punk do cinema – Suburbia (1983) e Repo Man: a onda punk (1984) – para mostrar como uma cultura subversiva se transforma em produto cultural, em diálogo com o conservador cinema hollywoodiano.
O roteiro de A hora dos ruminantes – os limites do literário e a ferramenta do narrador-cantador
Authors: Cordeiro de Mello Marcelo
Published: October 2021

Tratamos aqui do roteiro cinematográfico não-filmado e inédito de A hora dos ruminantes, escrito pelo cineasta Luiz Sergio Person e pelo crítico e roteirista Jean-Claude Bernardet em 1967, adaptado da obra de José J. Veiga. Discutimos o caráter literário do roteiro a partir da aproximação intertextual com o conto Cara de Bronze de João Guimarães Rosa, e tratamos do problema do narrador, em especial do narradorcantador, em diálogo com o filme Deus e o Diabo na terra do sol de Glauber Rocha.
TERMORREGULAÇÃO E EQUILÍBRIO HÍDRICO NO EXERCÍCIO: ASPECTOS ATUAIS E RECOMENDAÇÕES
Authors: Melo-Marins Denise De , Souza-Silva Ana Angélica , Silami-Garcia Emerson , Laitano Orlando
Published: October 2021

A evaporação de suor é o principal mecanismo de termorregulação humana durante exercícios realizados na superfície terrestre. Este importante mecanismo fisiológico de manutenção da homeostase térmica, todavia, pode levar a uma perda significativa de fluidos corporais, causando a desidratação. Evidências demonstram que a perda de líquido correspondente a 2% da massa corporal é suficiente para causar redução na capacidade de desempenho físico. Portanto, evitar a desidratação ingerindo líquido durante o exercício é importante não só para se manter a capacidade de desempenho físico, como também para se prevenir contra problemas associados à hipertermia. Sendo assim, o objetivo desta revisão é discutir os efeitos da desidratação no desempenho físico de atletas e pessoas que praticam exercícios com o objetivo de obter melhoras na aptidão física. Além disso, são apresentadas formas de se identificar e avaliar a desidratação em praticantes de exercícios, bem como aspectos relevantes para a elaboração de uma estratégia eficiente de hidratação para evitar a desidratação e também o consumo excessivo de líquidos antes, durante e após o exercício.
EFFECTS OF CONCURRENT TRAINING ON MORPHOFUNCTIONAL PARAMETERS AND BLOOD PRESSURE IN HYPERTENSIVE WOMEN
Authors: Aguiar Renata Emilia Marques , Teixeira Cauê Vazquez La Scala , Paulino Heverton , Pauli José Rodrigo , Medeiros Alessandra , Cerrone Letícia Andrade , Ferreira Sionaldo Eduardo , Gomes Ricardo José
Published: October 2021

Aerobic and resistance exercise have been prescript to prevention and non pharmacological treatment of hypertension. However, there is a lack of studies investigating the effects of concurrent training in hypertensive women. Thus, the aim of this study was to investigate the effects of concurrent training program on rest blood pressure, biochemical variables (blood glucose and total cholesterol) , anthropometric (body mass index and waist circumference) and functional fitness in hypertensive women. Eighteen hypertensive postmenopausal and untrained women (59±12 years old) started in the intervention, but only ten subjects finished. The voluntaries were enrolled in concurrent training, 60 min/day, 3 times a week, during 6 months. Systolic and diastolic blood pressure, blood glucose, total cholesterol, body mass index, waist circumference and functional fitness (AAPHERD) were measured pre and post experimental period. Data were analyzed using the Student’s t test with significance level set at 5% (P?0.05) and Cohen's Effect Size (ES). The results showed significant improvement in systolic and diastolic blood pressure at rest. The other variables did not show significantly changes, but the ES was medium and large for several variables (body mass index, blood glucose, total cholesterol, agility, coordination, aerobic fitness, strength endurance and general functional fitness index). In conclusion, this study confirms that 6 month of concurrent training program improved systolic and diastolic blood pressure in hypertensive women. In addition, the protocol suggests an improvement in anthropometric, biochemical and functional variables related to health.
A INGESTÃO AGUDA DE ENERGY DRINK AUMENTA O DESEMPENHO EM EXERCÍCIOS RESISTIDOS
Authors: Polito Marcos , Souza Diego , França Douglas
Published: October 2021

O objetivo do presente estudo foi verificar a influência aguda da ingestão da bebida energética que contem cafeína ou “energy drink” (ED) sobre o desempenho na execução de exercícios resistidos para membros superiores e inferiores. A frequência cardíaca (FC) foi analisada como variável complementar. Participaram do estudo 15 indivíduos (9 homens e 6 mulheres: 21,6 ± 0,5 anos; 171,1 ± 2,3 cm e 66,1 ± 2,6 kg), saudáveis e treinados. Em um delineamento duplo-cego, cruzado e aleatorizado, os indivíduos realizaram duas sessões experimentais (com intervalo mínimo de 48h) nos exercícios de extensão de joelhos e supino articulado (75% 1RM até a exaustão, 3 séries, 90 s de intervalo entre as séries, 3 min de intervalo entre os exercícios). Em um dia a amostra ingeriu ED (2,5 mg de cafeína por kg de peso corporal) ou placebo 60 min antes do treinamento. As bebidas foram equalizadas pela quantidade calórica. A FC foi medida em repouso, 60 min após a ingestão e ao fim de cada série de cada exercício. Os resultados mostraram que a ingestão de ED proporcionou maior quantidade total de repetições em relação ao placebo no supino (27,3±2,8 vs 23,9±3,0; P=0,03) e na extensão de joelhos (36,0±2,2 vs 33,8±2,1; P=0,02). A FC ficou mais elevada após a ingestão de ED (P
Health Issues of Complicacy among Relationships
Authors: Mohiuddin Abdul
Published: October 2021

On Valentine's Day, the sight of couples holding hands and hugging each-other might unleash a wave of jealousy in those who are single. However, there might not be much to be jealous about. Also, marital quality clearly colors one’s overall sense of well-being, and marital distress elevates health risks, says a leading clinical psychology journal. However, the simple presence of a spouse is not necessarily protective; a troubled marriage is itself a prime source of stress, and simultaneously limits the partner's ability to seek support in other relationships. The worst distance between two persons in a relationship misunderstanding. Indeed, the relationship between life satisfaction and marital quality is stronger than life satisfaction’s ties to either one's job or one’s health.
Efficacy of prophylactic versus therapeutic administration of the NMDA receptor antagonist MK-801 on the acute neurochemical response to a concussion in a rat model combining force and rotation
Authors: Masse Ian , Moquin Luc , Bouchard Caroline , Gratton Alain , De Beaumont Louis
Published: October 2021

OBJECTIVE

Alterations in amino acid concentrations are a major contributor to the persistent neurological and behavioral effects induced by concussions and mild traumatic brain injuries (TBIs). Glutamate, the most abundant excitatory amino acid in the CNS, has a major role in the pathophysiological process of concussion. The indiscriminate liberation of glutamate immediately after a concussion triggers an excitotoxic response that leads to cell death, neuronal damage, and the dysfunction of surviving neurons, largely by overactivation of N-methyl-d-aspartate (NMDA) glutamatergic receptors. The aim of the present study was to investigate the efficacy of prophylactic versus therapeutic administration of MK-801, a promising NMDA receptor antagonist, on the acute changes in amino acid extracellular concentrations involved in excitotoxicity resulting from a concussive trauma.

METHODS

The immediate neurochemical response to a concussion cannot be characterized in humans. Therefore, the authors used their previously validated combination of a weight-drop concussion rat model and in vivo cerebral microdialysis. The microdialysis probe was inserted inside the hippocampus and left inserted at impact to allow uninterrupted sampling of amino acids of interest immediately after concussion. The primary outcome included amino acid concentrations and the secondary outcome included righting time. Samples were taken in 10-minute increments for 60 minutes before, during, and 60 minutes after impact, and analyzed for glutamate, gamma-aminobutyric acid, taurine, glycine, glutamine, and serine using high-performance liquid chromatography. Righting time was acquired as a neurological restoration indicator. Physiological saline or 10 mg/kg MK-801 was administrated intraperitoneally 60 minutes before or immediately following induction of sham injury or concussion.

RESULTS

Following induction of concussion, glutamate, taurine, and glycine levels as well as righting times in cases from the MK-801 treatment group were comparable to those of vehicle-treated animals. In contrast, righting times and amino acid concentrations observed within the first 10 minutes after induction of concussion in cases assigned to the MK-801 prophylaxis group were comparable to those of sham-injured animals.

CONCLUSIONS

These results suggest that presynaptic actions and peak availability of MK-801 following prophylactic administration significantly inhibit the immediate and indiscriminate release of glutamate, taurine, and glycine in extracellular fluid after a concussion.
Lack of somatotopy among corticospinal tract fibers passing through the primate craniovertebral junction and cervical spinal cord: pathoanatomical substrate of central cord syndrome and cruciate paralysis
Authors: Morecraft Robert J. , Stilwell-Morecraft Kimberly S. , Ge Jizhi , Kraskov Alexander , Lemon Roger N.
Published: October 2021

OBJECTIVE

In some cases of incomplete cervical spinal cord injury (iSCI) there is marked paresis and dysfunction of upper-extremity movement but not lower-extremity movement. A continued explanation of such symptoms is a somatotopic organization of corticospinal tract (CST) fibers passing through the decussation at the craniovertebral junction (CVJ) and lateral CST (LCST). In central cord syndrome, it has been suggested that injury to the core of the cervical cord may include selective damage to medially located arm/hand LCST fibers, without compromising laterally located leg fibers. Because such somatotopic organization in the primate CST might contribute to the disproportionate motor deficits after some forms of iSCI, the authors made a systematic investigation of CST organization in the CVJ and LCST using modern neuroanatomical techniques.

METHODS

High-resolution anterograde tracers were used in 11 rhesus macaque monkeys to define the course of the corticospinal projection (CSP) through the CVJ and LCST from the arm/hand, shoulder, and leg areas of the primary motor cortex (M1). This approach labels CST fibers of all sizes, large and small, arising in these areas. The CSP from the dorsolateral and ventrolateral premotor cortex and supplementary motor area were also studied. A stereological approach was adapted to quantify labeled fiber distribution in 8 cases.

RESULTS

There was no evidence for somatotopic organization of CST fibers passing through the CVJ or contralateral LCST. Fiber labeling from each cortical representation was widespread throughout the CST at the CVJ and LCST and overlapped extensively with fibers from other representations. This study demonstrated no significant difference between medial versus lateral subsectors of the LCST in terms of number of fibers labeled from the M1 arm/hand area.

CONCLUSIONS

This investigation firmly rejects the concept of somatotopy among CST fibers passing through the CVJ and LCST, in contrast with the somatotopy in the cortex, corona radiata, and internal capsule. All CST fibers in the CVJ and LCST would thus appear to be equally susceptible to focal or diffuse injury, regardless of their cortical origin. The disproportionate impairment of arm/hand movement after iSCI must therefore be due to other factors, including greater dependence of hand/arm movements on the CST compared with the lower limb. The dispersed and intermingled nature of frontomotor fibers may be important in motor recovery after cervical iSCI.