bluuebunny/crossref_metadata_2025 huggingface dataset:
Relación entre prácticas parentales de alimentación y los desempeños de aprendizaje durante la pandemia del COVID-19 en niños de 3 - 5 años de dos Instituciones Educativas de Balnearios de Lima Sur, Lima-Perú 2022
Authors:   , Manrique Saavedra Desny Yugaly
Published: January 2025

Introducción: La pandemia a causa del Covid-19 ha generado un gran impacto para la salud principalmente en la nutrición de los niños(as), debido al inadecuado consumo de sus alimentos ocasionado por los padres de familia en las malas prácticas de crianza en la alimentación, lo que repercute principalmente en su crecimiento y desarrollo, como en la capacidad de atención, memoria y concentración durante el aprendizaje. Objetivo: Evaluar la relación entre prácticas parentales de alimentación y los desempeños de aprendizaje en niños de 3 a 5 años durante la pandemia del Covid-19 de dos Instituciones Educativas de Balnearios de Lima Sur, Lima-Perú, 2022. Materiales y métodos: Estudio no experimental, transversal y analítico, aplicado en una población de padres y niños de dos instituciones educativas de Balnearios de Lima-Sur durante la pandemia del Covid-19. Se empleó un cuestionario sobre las Prácticas Parentales de Alimentación; y además se obtuvo las calificaciones de los niños(as) en base a sus informes de progresos. Los datos fueron recopilados en el formulario de Google Forms y procesados en Microsoft Office Excel y luego en el software estadístico SPSS versión 28. Resultados: La relación no fue estadísticamente significativa (p>0.05) entre las prácticas parentales de alimentación y los desempeños de aprendizaje en niños de 3 a 5 años durante la pandemia por Covid-19 en ambas Instituciones Educativas. Conclusión: No existió relación entre las prácticas parentales de alimentación y los desempeños de aprendizajes en niños de 3 a 5 años durante la pandemia por Covid–19 en las dos Instituciones Educativas.
Relación entre el nivel de conocimientos y prácticas de estilos de vida saludable en pacientes con diabetes mellitus tipo 2 hospitalizados en el área de Medicina General de un hospital peruano
Authors:   , Nieto Vidarte Milagros Estefani , Mañuico Huaraca Romina Coraima
Published: January 2025

Antecedentes: la hiperglucemia crónica es una característica distintiva de la diabetes mellitus tipo 2, al no ser controlada puede tener complicaciones a corto y largo plazo; los estilos de vida son un papel fundamental en el manejo de la enfermedad y alrededor de 62 millones de personas en las Américas viven con diabetes. Objetivo: determinar la relación entre el nivel de conocimientos y las prácticas de estilos de vida saludable en pacientes con diabetes mellitus tipo 2 hospitalizados en el área de Medicina General de un hospital peruano. Materiales y métodos: se realizó un estudio con diseño analítico, transversal en 114 pacientes. El nivel de conocimientos y prácticas de estilo de vida se determinaron a través de cuestionarios autoaplicados. Para determinar la relación entre el nivel de conocimiento y los estilos de vida, se aplicó la prueba de Chi-cuadrado con un intervalo de confianza del 95% y un p < 0,05. Resultados: el 50% de participantes presentó un nivel de conocimiento regular, mientras que el otro 50% posee un bajo nivel de conocimiento. Con respecto al estilo de vida, el 62,3 % presentó un estilo de vida poco favorable. Los análisis estadísticos nos indican que no hay relación significativa (p=0.181) entre el nivel de conocimiento sobre la diabetes mellitus y la práctica de estilos de vida. Conclusiones: no se identificó una relación significativa entre las variables de nivel de conocimiento sobre la enfermedad y prácticas de estilos de vida. Debido a que aún existe desconocimiento en pacientes hospitalizados sobre la enfermedad y las prácticas idónea, se sugieren futuros estudios para establecer intervenciones o estrategias adecuadas para la prevención de la diabetes.
Análisis bibliométrico de la tendencia de las publicaciones latinoamericanas sobre resistencia microbiana en el periodo 2012-2021 en Scopus
Authors:   , Diaz Huamani Yahaira Karelli , Vargas Vargas Jose Rolando
Published: January 2025

Introducción breve: La resistencia antimicrobiana es un problema que interesa más a la Medicina Humana por las múltiples consecuencias que genera en el sector salud y en los diferentes sectores que abarca, por eso la investigación de la resistencia microbiana está en aumento, pero se conoce poco de este tema en Latinoamérica. Objetivo: Determinar la tendencia de las publicaciones Latinoamericanas sobre resistencia microbiana en el periodo 2012-2021 en Scopus. Materiales y métodos: Estudio observacional, la población se obtuvo mediante una búsqueda en Scopus. Resultados: Se analiza 4582 publicaciones Latinoamericanos sobre resistencia microbiana del año 2012 al año 2021 considerándose 1002 artículos Un 87.43% de publicaciones están en inglés y el año 2019 destaca con 134 publicaciones. La revista con mayor producción es “Brazilian Journal of Infectious Diseases”. Los países destacados en producción científica son Brasil, México y Argentina. Las dos primeras instituciones con mayor actividad científica son de Brasil y los autores Freire M.P, Paniagua-Contreras G.L, Perez L.R.R son los más productivos. Además, se discute datos del 2022 hasta el 2024. Conclusiones: Durante el periodo 2012 a 2021 se publicaron 1002 artículos pertenecientes a 32 revistas, el 87.43% de publicaciones fue en inglés con un total de 10392 citas. El país con mayor producción es Brasil al igual que la revista, institución y el autor, el año con mayor producción es 2019. Se encontró que más de la mitad de publicaciones tienen una buena calidad de publicaciones.
Systematic review of clinical practice guidelines for the diagnosis and management of open angle glaucoma
Authors: Galvez-Olortegui Jose , Jarroudi Rachid Bouchikh-El , Silva-Ocas Isabel , Bernales-Urbina Susan , Mollo-Bautista Rosmery , Burgueño-Montañes Carmen , Galvez-Olortegui Tomas
Published: January 2025

Background/Objectives: To assess the methodological quality of Clinical Practice Guidelines(CPG) for the diagnosis and management of open angle glaucoma(OAG). Methods: A systematic review of CPGs for the diagnosis and management of OAG, published between January-2017 and November-2024, was carried out with a search in databases, meta-search engines, CPG development institutions, ophthalmology associations and CPG repositories(PROSPERO:CRD42024510656). 5 authors evaluated them independently, using the Appraisal of Guidelines for Research and Evaluation (AGREE-II) instrument. An individual assessment by domain (AGREE-II), an overall assessment of the guide, and its use with or without modifications was performed. Additionally, a meta-synthesis of the recommendations for the most relevant outcomes was carried out. Results: The lowest mean scores were in applicability and rigour of development(mean 43.2% and 46.1% respectively). The highest score(mean 73.9%) was for domain 4-‘Clarity of presentation’. NICE(92.1%), IETSI(77.5%) and SNSG(75.8%) presented the best score in domain 3-‘Rigour of development’. Only NICE, EGS-5-TGG, SNS, and MaHTAS are recommended, the last two with modifications when evaluating the overall quality of the analyzed CPGs. Most of the CPGs used GRADE approach for making recommendations. In the meta-synthesis, the CPGs show similar recommendations, however, we found variability in indications for selective laser trabeculoplasty(SLT) and minimally invasive glaucoma surgery(MIGS). Conclusions: NICE, IETSI and SNSG CPGs for the diagnosis and management of OAG have a high methodological quality, appraised with AGREE-II. NICE, EGS-5-TGG, IETSI and SNSG have high scores in applicability.
Phase-interface-anchored cadmium single-atom catalysts for efficient methanol steam reforming
Authors: Wang Hui , zhang shunan , Zhou Haozhi , Shao Zilong , Wei Baohuan , Hu Zhen , Liang Hao , Zhang Ruonan , Liu Xiaofang , Luo Hu , Xia Lin , Sun Yuhan
Published: January 2025

Employing interface engineering to design innovative single-atom catalysts (SACs) for effective methanol steam reforming (MSR) presents an attractive yet formidable challenge. Herein, we report phase-interface confined Cd/P25 SACs, where Cd atoms are stably anchored at the phase interface between anatase (101) and rutile (110) facets. The formed Cd-O-Ti phase interface sites exhibit asymmetric geometric and electronic properties that achieve 100% methanol conversion, minimal CO selectivity (<0.1%), and sustained stability exceeding 150 hours. The H2 production rate at these interface sites was approximately 15-fold and 8-fold higher than that of anatase and rutile surface sites, respectively. Enhancing the phase interface density through atmosphere pretreatment can further increase the H2 production rate by an additional 11%. Furthermore, these powder SACs can be 3D printed into kilogram-scale monolithic catalysts, advancing practical in-situ hydrogen generation applications. We anticipate that the strategy presented here will be instrumental in the design of novel SACs and in advancing the application of MSR.
Identification and characterization of phosphorus deficiency tolerant rice genotypes in North-eastern India
Authors: Devi Sanatombi , Singh Th. Seileshkumar , Devi E. Lamalakshmi , W.S. Philanim , Roy Somnath , kumar Amit , Devanna Pramesh , Kumar Awadhesh , T Basanta Singh , Kh Rishikanta Singh , Akoijam Ratankumar Singh , laha Ramgopal , Ngangkham Umakanta
Published: January 2025

An essential element for healthy plant growth and development is phosphorus (P). Globally, lack of phosphorus (P) is a major factor affecting rice productivity. P insufficiency issues generally occur in iron-toxicity soils, soils with aluminium or manganese content, and acidic soils which accounts for over 80% of the area of land in North Eastern India. Also, 60–80% P of rice plants is deposited and stored in the form of phytate which also chelates the availability of Zn and Fe making them unavailable to human and monogastric animals and subsequently environmental pollution and eutrophication. To address the challenges to food and nutrition security, it is crucial to identify high P absorption ability from soil simultaneously reduced P in rice grains using available untapped plant genetic resources. In the present investigation, 96 rice germplasm were screened for phosphorous tolerance using Pup1 gene-based markers. Based on two markers (K46 and K20), only 15 genotypes (15.63%) were positive for PUP1 gene. Hydroponic treatment with low phosphorus revealed Mata Maha and Chakhao Lamhing as the most tolerant genotypes to P deficiency. The correlation analysis found that P was significantly and positively correlated with Fe (0.551) and Zinc content with Fe (0.480). The range of P content was 0.27–3.78mg/g with an average of 1.81mg/g. Intriguingly, the PUP1 gene is also significantly associated with P content in grain by enhancing the P content which is an undesirable trait. However, Insatang Makokching rice genotype showed the least P content (0.27mg/g) in grain though the presence of the positive PUP1 gene. A single nucleotide substitution (G/C) in the eight-exon position of SPDT gene altering the amino acid glycine (G) to arginine (R) in Insatang Makokching rice genotype could be the reason for lowering P content via altering the function of the SPDT protein in node I of panicles. Therefore, convergent selection of PSTOL1 and SPDT genes in rice would enhance low phosphorus tolerance while reduced P grain content ensuring rice agricultural sustainability concerning to phosphorus fertilizers.
Comparative Analysis of Elderly Hip Fractures in COVID-19 Recovered Patients and Non-Infected Patients: Surgical Intervention, Postoperative Complications, and Short-term outcomes
Authors: Yang Qianhao , Yan Yufei , Di Jianzhong , Rui Biyu
Published: January 2025

Objectives: This study aims to compare surgical intervention, postoperative complications, and short-term outcomes of hip fracture surgery in elderly patients who have recovered from COVID-19 infection with those who have not been infected.
Methods: Patients aged older than 65 years consecutively admitted hip fracture to the Trauma and Orthopedics Centre of a third-level hospital, between January and April 2023. Medical records and databases were reviewed from hospital information system. Patient information, including diagnosis, demographic characteristics, imaging data, laboratory examinations, treatments and length of hospital stay were collected. A structured follow-up assessment was conducted at 1, 3 and 6 months after hospital discharge. Mortality, rehospitalization and postoperative complication were recorded and compared.
Results: Of 312 patients with hip fracture, 252 (mean age 78 years, female 69%) were enrolled. The basic patient information and surgery-related indicators showed no significant differences between the experimental group and the control group. Similarly, COVID-19 infection did not have a significant impact on hospital stay duration or short-term complications. However, the six-month postoperative survival rate was significantly lower in the infected group compared to the non-infected group.
Conclusions and implications: The COVID-19 pandemic has had a significant impact on global healthcare systems. Which may significantly affect postoperative survival compared to the non-infected group. Further research is needed to understand the long-term effects of COVID-19 on musculoskeletal health and its implications for rehabilitation in this specific patient population.
Relationship of the novel Left Ventricular–Arterial Coupling index to COVID-19 severity and all-cause mortality
Authors: Wu Lingheng , Chen Jianxiong , Zhang Mengjiao , Jin Lin , Ning Wang , Jing Ma , Luo Xianghong , Li Zhaojun , Du Liangfang
Published: January 2025

Objective This study sought to investigate the prognostic impact of a novel ventricular-vascular coupling index, the arterial velocity pulse index (AVI) to left ventricular global circumferential strain (GCS) ratio (AVI/GCS) in patients with COVID-19.
Methods 217 patients who were diagnosed with COVID-19 were retrospectively reviewed over a 2- month period, and were stratified into two groups (mild and moderate/severe). The traditional indexes (effective arterial elastance, Ea, left ventricular end-systolic elastance, Ees, and ventricular-vascular coupling index, VVI) and the novel indexes (AVI, GCS, AVI/GCS) were acquired. Receiver operating characteristic curve (ROC) analysis was used to compare the diagnostic efficacy of the two indexes and established the optimal cut point. Cox proportional hazard models were used to evaluate the associations with AVI/GCS and all-cause mortality.
Result Among 217 patients analyzed, and 46.54% of the patients were male. The moderate/severe group showed higher values of VVI and lower AVI/GCS compared to mild group. The AVI/GCS [AUC 0.856, 95%CI 0.803-0.909] showed improvement in model discrimination compared with the other ventricular-arterial coupling indexes (Ea, Ees, VVI, AVI and GCS), with the cutoff value of -65.85.
The AVI/GCS ratio <-65.85 vs >-65.85 was associated with an increased risk of all-cause mortality (HR: 4.801; 95% CI: 1.095-21.054).
Conclusions AVI/GCS was more effective in detecting differences in cardiovascular function, and was a strong predictor of adverse outcomes in COVID-19 patients.
Post-fire recolonization of dry deciduous forests by lemurs in northwestern Madagascar
Authors: Rabemananjara Naina Ratsimba , Rasolozaka Misa Miaritiana , Ravolanirina Marie Odile , Marivola Rogula , Randriamiarantsoa Seheno Harilala , Rakotondravony Romule , Razafindraibe Hanta , Schüßler Dominik , Radespiel Ute
Published: January 2025

Wildfires significantly threaten biodiversity, especially in tropical regions like Madagascar, where unique ecosystems face ongoing habitat loss and degradation. This study investigated the effects of forest fires on lemur abundance, species richness, and their ability to recolonize burnt vegetation in Ankarafantsika National Park (ANP), the largest protected dry deciduous forest in northwestern Madagascar. ANP hosts eight lemur species with one diurnal (Propithecus coquereli), two cathemeral (Eulemur mongoz, E. fulvus), and five nocturnal species (Avahi occidentalis, Lepilemur edwardsi, Cheirogaleus medius, Microcebus murinus, and M. ravelobensis). Eighteen sites with varying fire histories (1 to > 35 years post-fire) and adjacent unburnt forest parts were surveyed using diurnal and nocturnal distance sampling. Transects included burnt (700 m) and unburnt (500 m) sections. Generalized linear mixed models (GLMMs) assessed the effect of fire variables such as time since the last fire, number of fires, intervals between fires, and fire severity on lemur abundance and species richness. A full lemur community was observed only in unburnt forests and areas with extended post-fire recovery (≥ 23 years). Fires negatively impacted E. fulvus and L. edwardsi, while they did not significantly affect the abundance of small nocturnal species (C. medius, Microcebus spp.). Lemur species richness was higher in unburnt zones and decreased with an increasing number of fires. These findings reveal the need for long recovery periods for lemur communities post-fire, suggest species-specific fire vulnerabilities, and demonstrate significant faunal impacts of this destructive driver of landscape transformation.
A 10-Year Experiences in Pediatrics with Idiopathic Intracranial Hypertension: Prevalence of Preterm Birth, Delivery Methods, and the Correlation Between Preterm Birth and Delivery Type with the Development of Idiopathic Intracranial Hypertension
Authors: Ashrafi Mahmoud Reza , Kahdouei Mohammadsadegh Talebi , Badv Reza Shervin , Heidari Morteza , Zamani Gholamreza , Sohrabi Behnaz , Aghaei Fatemeh , Banitaba Fatemeh Sadat , Memar Elmira Hajiesmaeil , Rezaei Zahra
Published: January 2025

Background: Idiopathic intracranial hypertension (IIH) refers to a condition where intracranial pressure increases without an identifiable cause. If left untreated, it can become life-threatening. Identifying risk factors is crucial for timely intervention and follow-up care. This study aims to evaluate the prevalence of IIH in preterm children, investigate the type of delivery, and explore the relationship between delivery type, preterm birth, and increased intracranial pressure in these patients, with the goal of identifying potential risk factors for better management and follow-up.Methods: This retrospective study was approved by the Ethics Committee of Tehran Children's Medical Center and included patients diagnosed with IIH referred to the center from January 2014 to January 2024. Patient records were reviewed and categorized into four groups based on the revised Friedman criteria. Neuroimaging findings, assessed by a neuroradiologist, included empty sella, globe flattening, perioptic subarachnoid space distension, and transverse venous sinus stenosis. Demographic data, clinical symptoms, gestational age (preterm vs. term), and delivery type (NVD vs. cesarean section) were documented. Inclusion criteria required elevated lumbar CSF opening pressure with no other identifiable causes of intracranial hypertension. Written consent was obtained from all participants or their guardians.Results: In this study, 119 patients (mean age: 8.91 ± 4.26 years; 22.9% female) were examined, with an average BMI of 20.37 ± 6.06. Clinical symptoms included headaches (61.3%), nausea/vomiting (34.5%), diplopia (27.7%), and blurred vision (25.2%). Preterm births accounted for 37.81%. No significant correlations were found between CSF pressure and age, gender, BMI, symptoms, gestational age, or delivery type. Patients with papilledema were significantly older (10.05 vs. 8.40 years). Neuroimaging findings included transverse venous sinus stenosis (5.04%) and other abnormalities at low frequencies.Conclusion: This study found no significant association between the type of delivery or gestational age and the development of IIH. However, IIH prevalence was higher in patients born preterm or via cesarean section. The study suggests that reducing cesarean section and preterm birth rates could help lower IIH prevalence. Increasing natural deliveries and ensuring regular follow-ups for preterm infants may further reduce IIH incidence.
Filtering-based preconditioner for accelerated high-dimensional cone beam CT image reconstruction
Authors: Wettenhovi Ville-Veikko , Hietanen Ari , Niinimäki Kati , Vauhkonen Marko , Kolehmainen Ville
Published: January 2025

Model-based image reconstruction algorithms are known to produce high-accuracy images but are still rarely used in cone beam computed tomography. One of the reasons for this is the computational requirements of model-based iterative algorithms, as it can take hundreds of iterations to obtain converged images. In this work, we present a measurement space-based preconditioner applied to the primal-dual hybrid gradient (PDHG) algorithm. The method is compared with the regular PDHG, FISTA, and OS-SART algorithms, as well as to a PDHG algorithm where the step-size parameters are adaptively computed. All tested algorithms utilize subsets for acceleration. The presented filtering-based preconditioner can obtain convergence in 10 iterations with 20 subsets, compared to a hundred or more iterations required by the other tested methods. The presented method is also computationally fast and has only a 15% increase in computation time per iteration compared to PDHG without the preconditioner.
Effect of Esg Performance on Portfolio Performance – a Study of Portfolios of Nifty-indexed Stocks in India
Authors: Rajan Rajeev , Sivakumar N.
Published: January 2025

Environmental Social and Governance (ESG) based investing has gained traction in the current times. In order to become popular and gain acceptance, it would be useful to show that portfolios comprising stocks of companies with higher ESG scores provide superior risk adjusted returns in comparison to portfolios created out of stocks of corporates with lower ESG scores. The current paper attempts to study this, using portfolios constructed out of stocks comprising the NIFTY index in the Indian capital market. Using a quantile approach, the study compares the risk adjusted returns of portfolios using three measures namely Sharpe ratio, Treynor ratio and Jensen’s alpha for a period of nine years from 2014-15 to 2022-23. The results show that on the overall, portfolios with stocks of companies with higher ESG ratings provide higher risk-adjusted returns compared to portfolios with stocks of companies with lower ESG scores.
JEL Classification Code: G110
Geospatial based assessment of Groundwater Potential Zones using MIF technique in a watershed of Malwa region, Madhya Pradesh, India
Authors: M. Priyamvada , Awasthi M. K.
Published: January 2025

Water is a major natural resource and a key constituent of all living beings. Water is available in two introductory forms i.e. surface water and groundwater. One of the most important accumulated resources in the world is groundwater, which is inversely distributed around the world. To boost the groundwater-recharge is one of the primary hydrological parameters for assessment, budgeting, management, and modelling of ground water resources. Although information and data regarding recharge rate is vital for recharge assessment of any region, determination of this parameter is not easy and straigntforward. The current study has been conducted in northwest part of Madhya Pradesh. The Neemuch and Mandsaur district comes under semi-arid zones and faces the problem of scarcity of water annually. Thus study aims to assess the groundwater recharge zones using an integrated approach of remote sensing and geographical information system (GIS). The parameters considered for identifying the groundwater potential zone of geology, slope, drainage density, soil, geomorphology and lineament density. These thematic maps were generated using the SRTM DEM, Sentinel-2 Imaginary and Survey of India (SOI) toposheets of scale 1:50000 and integrated them to identify the groundwater potential of the study area. Appropriate weightage factors were assigned for each class of these parameters. For the various geomorphic units, weightage factors were assigned based on their capability to store ground-water using multi-influencing factor (MIF). This procedure was repeated for all the other layers and resultant layers were re-classified. After reclassification, the layers were then united to demarcate zones as very good, good, moderate, poor and very poor. The assessment of groundwater potentiality information using RS & GIS could be used for effective identification of suitable locals for birth of potable water for rural populations.
Spatial Analysis and Visualization of School Enrollment in Somaliland: A Poisson regression model
Authors: Alin Abdirahman Osman
Published: January 2025

This study examines the spatial distribution and determinants of primary school enrollment in Somaliland for the 2021/2022 academic year, using a Poisson regression model to analyze regional disparities and their relationship with school availability. The gross enrollment ratio (GER) stands at 34.03%, while the net enrollment ratio (NER) is significantly lower at 25.28%, highlighting challenges in enrolling children within the official school-age group. Results reveal substantial regional disparities in enrollment, with Maroodi-Jeex and Togdheer emerging as regions with the highest enrollments due to better access to urban educational infrastructure. Conversely, rural areas like Hawdand Xaysimo exhibit low enrollment rates, emphasizing challenges such as remoteness and limited school resources.
The Poisson regression analysis underscores a significant positive association between the number of schools and total enrollment (p<2e-16), with each additional school contributing an approximate 0.88% increase in enrollment. However, urban schools show a negative relationship with total enrollment, suggesting complex dynamics in urban-rural resource allocation. Exceedance probability analysis identifies high-demand regions, such as Maroodi-Jeex and Togdheer, as areas requiring immediate intervention to address resource shortages. Discrepancies between actual and predicted enrollment further highlight the influence of unaccounted demographic and socioeconomic factors.
This study underscores the critical role of educational infrastructure in shaping enrollment patterns across Somaliland. The findings provide actionable insights for policymakers to address regional disparities by improving access to schools in underserved rural areas and optimizing resource allocation in high-demand regions in Somaliland. The study's methodology and results contribute to broader discussions on educational equity and access in Sub-Saharan Africa.
Identification of cuproptosis-related gene CDKN2A as a molecular diagnostic target in gastric carcinoma based on transcriptomic data
Authors: Chen Guo , Zhang Wenli , Wei Di , Li Zeng , Lu Jun , Liu Wenying , Wang Lei , Lu Zifan
Published: January 2025

Gastric Carcinoma (GC) is the world’s third-highest cause of death by cancer. Cuproptosis is a newly discovered programmed cell death dependent on overload copper-induced mitochondrial respiration dysregulation. We speculated this regulatory cell death (RCD) mechanism might serve as a potential prognostic predictors and therapy for GC patients. The expression and mutation patterns of 12 cuproptosis-related genes were systematically evaluated in the GC training group. Through unsupervised clustering analysis and developing a cuproptosis-related scoring system, we further explored the relationship between cuproptosis and GC progression, prognosis, immune cell infiltration, and immunotherapy. Molecular docking was used to screen the drugs which had the best binding affinity with cuproptosis target proteins. CCK8, invasion and migration assay were used to explore the anticancer effect of the drug which binging to the cuproptosis target protein and then verify it in nudes. Our results revealed three genes (CDKN2A, GLS, and MTF1) have predictive value for the prognosis. Patients from low-CRG score group were characterized by higher immune cell infiltration, immune checkpoint expression. Via molecular docking, CCK8, invasion and migration assay, saquinavir had the best binding affinity with CDKN2A,which could inhibit the proliferation, invasion, and migration of gastric carcinoma cells in vitro. Ani-mal experiment showed that saquinavir treated group had smaller volume and weight tumors. Our results confirmed the essential function of cuproptosis in regulating the progression, prognosis, immune cell infiltration, and response to immunotherapy. CDKN2A as the potential target for gastric carcinoma showed the anticancer effect in vitro and vivo.
High prevalence of EGFR R479K polymorphism in Head and Neck Cancer Patients of Indian origin and is associated with poor prognosis
Authors: Ghosh Arjita , Moorthy Anbalagan
Published: January 2025

Purpose
The Epidermal growth factor receptor (EGFR) gene, is one of the most altered gene reported across various cancers. EGFR is host to several single nucleotide polymorphism (SNP), like R497K. R497K is a common SNP of EGFR found in codon 497, which effects the function of the gene. HNSCC is one of the most commonly afflicted cancer found in Indian population.The current study was done to screen Indian patients suffering from Head and Neck squamous cell carcinoma (HNSCC), for this R497K SNP of EGFR. The study was performed to check the prevalence of this SNP in Indian population, and to correlate that data to the survival rates of the cohort.
Method
To screen this SNP, from HNSCC patients (n = 50), genomic DNA was extracted and polymerase chain reaction coupled with restriction fragment length polymorphism (PCR-RFLP) technique was applied for screening. We re-confirmed our PCR-RFLP data with Sanger sequencing. We then used Kaplan-Meier statistical analysis to corelate between our SNP data to the survival rates of our patients.
Results
Our study found, that in our cohort 84% carried this SNP, and only 16% were wild type. Our study reports decreased survival months in both overall survival (OS) and progression free survival (PFS) observed in the patients carrying the R497K polymorphism compared to the wild type patients.
Conclusion
Our study, hence concludes that the SNP R497K of EGFR gene has high prevalence in our Indian study population, which corelates with poor prognosis for HNSCC.
The Imagination of a Transoceanic Island: From Letter from Okinawa to Okinawa Spy
Authors: Cho Jung-Min , Oh Se-Jong
Published: January 2025

This study examines the methods and aspects of literary representation of the Japanese island Okinawa, focusing on the novels of authors Kim Jeong-han and Kim Soom. Okinawa is noted as a locale that shares a similar history with Korea, as both regions suffered under Japan’s colonial rule. Beyond this, however, Okinawa is also a place that invites broad reflection on the East Asian context of various themes, such as barbarism and violence, perpetration and victimization, and dominance and subjugation. In light of this, Kim Jeong-han and Kim Soom sought to portray Okinawa not merely as a place confined to historical memory, but as a symbolic space that reflects on the contemporary contexts of exclusion, violence, and hatred. This is accomplished by exploring such issues as state violence, gender oppression, and racial discrimination, which persist even in the 21st century. Through Okinawa, the authors aimed to uncover the overlapping structures existing between imperialism and colonialism. They also sought to suggest new possibilities for trans-locality by intersecting and expanding the historical experiences and events rooted in Okinawa into Korea, Japan, and the U.S. The reason Okinawa could serve as a hub of trans-locality lies in its geographical location at the southern tip of the Japanese archipelago and its experience of being an internal colony under Japanese rule. However, the manifold layers of differentiation and the presence of complex others within Okinawa also give it multiple identities, challenging the island to seek out new ways of thinking by constantly traversing, intersecting, and defying boundaries. Therefore, this study assesses how these various experiences, practices, and contemplations formed around Okinawa may offer points of academic inspiration and reflection for East Asia and the world in the future.
Kondo spectral functions at low-temperatures: A dynamical-exchange-correlation-field perspective
Authors: Zhao Zhen
Published: January 2025

We calculate the low-temperature spectral function of the symmetric single impurity Anderson model using a recently proposed dynamical exchange-correlation (xc) field formalism. The xc field, coupled to the one-particle Green’s function, is obtained through analytic analysis and numerical extrapolation based on finite clusters. In the Kondo regime, the xc field is modeled by an Ansatz that takes into account the different asymptotic behaviors in the small- and large-time regimes. The small-time xc field contributes to the Hubbard side-band, whereas the large-time to the Kondo resonance. We illustrate these features in terms of analytical and numerical calculations for small- and medium-size finite clusters, and in the thermodynamic limit. The results indicate that the xc field formalism provides a good trade-off between accuracy and complexity in solving impurity problems. Consequently, it can significantly reduce the complexity of the many-body problem faced by first-principles approaches to strongly correlated materials.
Many-body perturbation theory for strongly correlated effective Hamiltonians using effective field theory methods
Authors: Photopoulos Raphaël , Boulet Antoine
Published: January 2025

Introducing low-energy effective Hamiltonians is usual to grasp most correlations in quantum many-body problems. For instance, such effective Hamiltonians can be treated at the mean-field level to reproduce some physical properties of interest. Employing effective Hamiltonians that contain many-body correlations renders the use of perturbative many-body techniques difficult because of the overcounting of correlations. In this work, we develop a strategy to apply an extension of the many-body perturbation theory starting from an effective interaction that contains correlations beyond the mean-field level. The goal is to re-organize the many-body calculation to avoid the overcounting of correlations originating from the introduction of correlated effective Hamiltonians in the description. For this purpose, we generalize the formulation of the Rayleigh-Schrödinger perturbation theory by including free parameters adjusted to reproduce the appropriate limits. In particular, the expansion in the bare weak-coupling regime and the strong-coupling limit serves as a valuable input to fix the value of the free parameters appearing in the resulting expression. This method avoids double counting of correlations using beyond-mean-field strategies for the description of many-body systems. The ground state energy of various systems relevant for ultracold atomic, nuclear, and condensed matter physics is reproduced qualitatively beyond the domain of validity of the standard many-body perturbation theory. Finally, our method suggests interpreting the formal results obtained as an effective field theory using the proposed reorganization of the many-body calculation. The results, like ground state energies, are improved systematically by considering higher orders in the extended many-body perturbation theory while maintaining a straightforward polynomial expansion.
Effects of green intellectual capital, green accounting, and green innovation on firm value: The moderating role of return on assets
Authors: Astuti Tri , Ahmar Nurmala
Published: January 2025

This study examines the influence of green intellectual capital, green accounting, and green innovation on firm value and return on assets. Green intellectual capital refers to the knowledge and expertise of environmental sustainability, green accounting involves incorporating environmental costs into financial reporting, and green innovation focuses on developing environmentally friendly technologies and processes. Indicators for evaluating these factors include the Green Intellectual Capital Index, Global Reporting Index disclosures for green accounting, and green process and product innovation dimensions for green innovation. The study employs Warp PLS to analyze data from 88 companies listed on the Sustainable and Responsible Investment (SRI-KEHATI) index on the Indonesia Stock Exchange. The findings indicate that green accounting significantly enhances firm value, while green innovation does not show a direct impact. However, all three factors positively influence return on asset (ROA). The moderating role of ROA was found to strengthen the relationship between green intellectual capital and green accounting with firm value, but it did not moderate the effect of green innovation. ROA was used as an indirect financial indicator to formulate the company’s profitability and strategic sustainability planning. These results highlight the importance of embedding sustainability into business strategies to enhance financial and environmental performance.
Ambiente Escolar como Suporte para a Prevenção ao uso de drogas: uma Revisão Narrativa
Authors: Varela Lopes Isadora , Silva Pires Anna Priscyla , Pinheiro Araújo Bárbara , Lyra de Souza Bruna Vitória , Alves de Morais Samuel , Oliveira Pachú Clésia
Published: January 2025

A inserção do ambiente escolar como suporte para prevenção ao uso de drogas se revela como fator importante para qualidade de vida dos estudantes e da sociedade. As intervenções acerca do controle da dependência química de substâncias psicoativas se apresentam como fundamentais na prevenção ao uso de drogas entre estudantes, uma vez que alguns fatores como o uso frequente e precoce de substâncias psicoativas podem gerar danos à saúde física e mental desses indivíduos. Objetivou-se analisar o ambiente escolar como suporte para prevenção ao uso de drogas por meio de uma revisão narrativa. A presente revisão narrativa acerca do ambiente escolar como suporte para prevenção ao uso de drogas foi realizada durante os meses de junho e julho de 2023, utilizando bancos os dados Google Acadêmico e o Periódico CAPES, tendo sido selecionados 32 artigos para integrar a pesquisa. Os resultados obtidos demonstram que a escola representa um espaço fundamental para promoção de intervenções que discutam acerca da prevenção ao uso de drogas. Nesse sentido, o ambiente escolar, bem como os profissionais que atuam nesse campo, apresentam-se como agentes na promoção à qualidade de vida e saúde dos estudantes. Portanto, na promoção de ações que reflitam acerca da utilização de substâncias psicoativas e as consequências geradas pelo uso. Assim, faz-se necessário a participação de mais escolas e profissionais que promovam ações a respeito da temática, com o intuito de promover a qualidade de vida, a saúde e o controle da dependência química.
 
 
Palavras-chave: Escolas; Prevenção ao uso de drogas; Substâncias psicoativas.
Atuação do Enfermeiro no Cuidado do Paciente com Esclerose Múltipla na Atenção Básica
Authors: D'Avila Pereira Aline , Cristine Luci Vieira de Lima  , Eliane Ferreira Pinheiro  , Marcos Paulo Nunes de Oliveira  , Rafaela Figueiredo Silva  , Alessandra da Terra Lapa
Published: January 2025

O referido estudo apresenta como principal objetivo realizar um levantamento bibliográfico sobre a atuação do enfermeiro no cuidado do paciente com esclerose múltipla. Para tanto, foi utilizado como método a revisão integrativa da literatura que contou com a seleção de arquivos publicados em sites considerados idôneos pelas instituições acadêmicas, como BVS, Scholar e PuBMed. Após a seleção dos dados foram analisados de forma descritiva, por retratar o ponto de vista dos autores sobre a temática e qualitativa, por abordar a pesquisa sobre um aspecto subjetivo de fenômenos sociais e do comportamento humano. Foram utilizados os seguintes critérios de seleção: serem publicados nas referidas plataformas entre os anos de 2018 a 2023; contextualizarem dentro dos objetivos propostos no estudo; serem textos completos. Os resultados demonstraram que a esclerose múltipla (EM) e uma doença autoimune e tem como base a inflamação crônica e progressiva do sistema nervoso central que causa a morte dos oligodendrócitos, levando à destruição das camadas de mielina, identificadas como lesões no tecido nervoso. Concluiu-se que o enfermeiro é um importante profissional que atua diretamente com o paciente, buscando manter seu bem-estar, identificando de forma prévia as possíveis complicações advindas da doença, nas ações de assistência visando a promoção, prevenção, recuperação e reabilitação da saúde do indivíduo, família e comunidade.
Revolutionizing Cancer Treatment: Unveiling the Power of CAR T-cell
Therapy
Authors: Barjasteh Amir Hossein , Saebi Mostafa , Mahmoudi Mahmoud , Kheder Ramiar Kamal , Hashemy Seyed Isaac , Forouzanfar Fatemeh , Esmaeili Seyed-Alireza
Published: January 2025

Cancer is a significant health challenge worldwide, causing social and economic burdens. Despite
advancements in medicine, it remains a leading cause of death and is projected to increase by 2040. While conventional
treatments like surgery, radiation, and chemotherapy are effective, they often have severe side effects.
CAR T-cell (chimeric antigen receptor T-cell) treatment is a novel immunotherapy method personalized
to the patient's immune system and directly targets cancer cells. It originated in the 1980s, and advancements
have made it more effective. However, challenges remain, such as severe side effects, high costs, and manufacturing
variability. Despite these challenges, the treatment with CAR T-cells has shown remarkable success, especially
in hematologic malignancies. Though, it is new to solid tumours, ongoing research looks promising.
CAR T-cell therapy offers hope for fightingcancer, and it stands poised to redefine cancer treatment
paradigms, giving renewed optimism to patients globally.
Potential of Nature-derived Biopolymers for Oral Applications- A Mini-Review
Authors: Kumar Vijayalakshmi , Sundramoorthy Ashok k.
Published: January 2025

In recent years, there has been a growing emphasis on the "back-to-nature" movement,
which has brought biopolymers derived from natural sources into the spotlight. These biopolymers
are gaining attention for their versatile surface-active properties, anti-adhesive capabilities, excellent
biocompatibility, non-toxicity, biodegradability, and antimicrobial effectiveness against a wide
range of oral microorganisms, including both bacteria and fungi. Researchers have been actively
modifying these eco-friendly, nature-based biopolymers to enhance their interaction with surrounding
cells and tissues, improving their performance in vivo. This has led to innovative applications in
areas such as surface coatings, controlled drug delivery, tissue repair, and dental implant devices.
These advancements hold the potential to pave the way for the development of novel drug delivery
systems with enhanced therapeutic properties, ultimately supporting the creation of innovative formulations
for clinical use. This review aims to provide an up-to-date overview of recent developments,
explore potential future directions, and highlight the promising applications of nature-derived
biopolymers in oral healthcare.
Potential of Postbiotics for the Biodegradation of Xenobiotics: A Review
Authors: Khani Nader , Abedi Soleimani Roya , Homayouni Rad Aziz
Published: January 2025

In modern times, individuals are frequently subjected to a wide range of environmental
and chemical pollutants that are generated by industrial and agricultural activities. The contamination
of food by pesticides, biogenic amines, and mycotoxins represents a significant concern for
global food safety, and has economic and public health implications, particularly in newly industrialized
nations. A growing body of evidence suggests that prolonged exposure to food contaminants,
known as xenobiotics, can have adverse effects on human health. Although many strategies
for food decontamination are frequently used, they require specific conditions that are often difficult
to meet in many industrial sectors. Currently, a promising strategy for mitigating the potential
hazards associated with xenobiotics in food items involves the implementation of a biological detoxification
method utilizing probiotic strains and their corresponding enzymes. Numerous investigations
have corroborated the efficacy, practicality, and cost-effectiveness of postbiotics in impeding
xenobiotic-induced dysbiosis and mitigating their toxicological effects. This review aims to
summarize the current knowledge of the direct mechanisms by which postbiotics can influence the
detoxification of xenobiotics. Moreover, the effects of postbiotics on host response to exposure to
xenobiotics were discussed.
Image Findings from Dual-phase Computed Tomography Pulmonary Angiography for Diagnosing Tuberculosis-associated Fibrosing Mediastinitis
Authors: Zhang Mengdi , Bu Chao , Jiang Kaiyu , Long Xiaozhou , Sun Zhonghua , Cao Yunshan , Li Yu
Published: January 2025

Objective:

Fibrosing mediastinitis (FM) is a rare and benign disease affecting the mediastinum and often causes pulmonary hypertension (PH). Timely
diagnosis of PH caused by FM is clinically important to mitigate complications such as right heart failure in affected individuals. This retrospective
study aimed to analyze the CT imaging characteristics of TB-related FM in patients with tuberculosis (TB). Additionally, the study investigates the
underlying reasons contributing to the manifestation of symptoms.

Methods:

From April 2007 to October 2020, high-resolution CT (HRCT) and dual-phase CT pulmonary angiography images of 64 patients with suspected
FM diagnosed with PH at a tertiary hospital were examined. The imaging characteristics of these CT scans were analyzed, with a specific focus on
the TB-FM involvement of the pulmonary veins, pulmonary arteries, and bronchi (down to the segment level).

Results:

HRCT imaging revealed that fibrous tissue inside the mediastinum exhibited minimal or negligible reinforcement in TB-FM and diffuse fibrous
infiltration in the mediastinum and hilar areas. Notably, segmental bronchial and pulmonary artery stenosis are more pronounced and frequently
co-occurring than lobe-level stenosis. Pulmonary venous stenosis developed outside the pericardium, whereas pulmonary artery stenosis occurred
outside the mediastinal pleura. Furthermore, no isolated FM involvement in pulmonary veins was noticed in this cohort.

Conclusion:

HRCT imaging of TB-related FM presents unique features in certain regions of the bronchi, pulmonary veins, and pulmonary arteries. Thus, it is
imperative to accurately identify fibrous tissue involvement in mediastinal lesions for proper diagnosis and management of TB-FM.