bluuebunny/crossref_metadata_2025 huggingface dataset:
Edible Films and Coatings for Fresh Fish Packaging: Focus on Quality Changes and Shelf-life Extension
Authors: Socaciu Maria-Ioana , Semeniuc Cristina Anamaria , Vodnar Dan Cristian
Published: October 2018

Fresh fish is extensively consumed and is one of the most-traded food commodities in the world. Conventional preservation technologies include vacuum and modified atmosphere packaging, but they are costly since requires capital investment. In the last decade, research has been directed towards the development of antimicrobial packaging systems, as an economical alternative to these. This paper outlines antimicrobial films and coatings applied so far on fresh fish, their efficacy against targeted microorganism/group and effects on chemical quality of the product. Findings show that edible films/coatings incorporated with different active agents applied to fresh fish are able to inhibit the microbial growth and decrease the rate of fish nutrients degradation, thus preventing the formation of chemical metabolites; a shelf-life extension of 6 to 13 days was obtained for fish fillets, depending on the species on which the active packaging materials were applied. The manufacturing use of these formulations could lead to a significant reduction in fish waste, consequently, a diminution of economic losses for fish traders and retailers. Therefore, their industrial production and commercialization could be an exploitable sector by the packaging industry.
Evaluation of Systems’ Irregularity and Complexity: Sample Entropy, Its Derivatives, and Their Applications across Scales and Disciplines
Authors: Humeau-Heurtier Anne
Published: October 2018

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An Overview of Multi-Criteria Decision-Making Methods in Dealing with Sustainable Energy Development Issues
Authors: Siksnelyte Indre , Zavadskas Edmundas Kazimieras , Streimikiene Dalia , Sharma Deepak
Published: October 2018

The measurement of sustainability is actively used today as one of the main preventative instruments in order to reduce the decline of the environment. Sustainable decision-making in solving energy issues can be supported and contradictory effects can be evaluated by scientific achievements of multi-criteria decision-making (MCDM) techniques. The main goal of this paper is to overview the application of decision-making methods in dealing with sustainable energy development issues. In this study, 105 published papers from the Web of Science Core Collection (WSCC) database are selected and reviewed, from 2004 to 2017, related to energy sustainability issues and MCDM methods. All the selected papers were categorized into 9 fields by the application area and into 10 fields by the used method. After the categorization of the scientific articles and detailed analysis, SWOT analysis of MCDM approaches in dealing with sustainable energy development issues is provided. The widespread application and use of MCDM methods confirm that MCDM methods can help decision-makers in solving energy sustainability problems and are highly popular and used in practice.
Design and Controller-In-Loop Simulations of a Low Cost Two-Stage PV-Simulator
Authors: Vavilapalli Sridhar , Subramaniam Umashankar , Padmanaban Sanjeevikumar , Blaabjerg Frede
Published: October 2018

A PV-Simulator is a DC power source in which the current-voltage (I-V) characteristics of different PV arrays can be programmed. With a PV-simulator, the operation of the solar power conditioning systems can be validated at a laboratory level itself before actual field trials. In this work, design, operation and controls for a two-stage programmable PV-simulator required for the testing of solar power conditioning systems are presented. The proposed PV-simulator consists of a three-level T-type active front-end converter in the first stage and a buck-chopper-based DC-DC converter in the second stage. An active front-end rectifier using a three-level T-type IGBT-based converter is used at the input stage to help in operating the system at unity power factor. A DC-DC converter at the output stage of the simulator is regulated to obtain the I-V characteristics of the programmed PV-Array. Hardware-In-Loop simulations are carried out to validate the proposed system and the associated controls implemented in the controller. As a case study, this PV-simulator is programmed with electrical parameters of a selected PV-array and the characteristics obtained from the PV-simulator are compared with the actual PV-array characteristics. The dynamic response of the system for sudden changes in the load and sudden changes in irradiance values are studied.
Enhancing Capabilities of Double Sided Linear Flux Switching Permanent Magnet Machines
Authors: Ullah Noman , Basit Abdul , Khan Faisal , Ullah Wasiq , Shahzad Mohsin , Zahid Atif
Published: October 2018

Double sided linear flux switching permanent magnet machines (DSLFSPMMs) exhibit high thrust force density, high efficiency, low cost and robust double salient secondary (stator) structures. The aforementioned unique features make DSLFSPMM suitable for long stroke applications. However, distorted flux linkage waveforms and high detent forces can exaggerate thrust force ripples and reduce their applicability in many areas. In order to enhance thrust force performance, reduce thrust force ripple ratio and total harmonic distortion (THD) of no-load flux linkages, two structure-based advancements are introduced in this work, i.e., asynchronous mover slot and stator tooth displacement technique (AMSSTDT) and the addition of an active permanent magnet end slot (APMES). Furthermore, single variable geometric optimization (SVGO) is carried out by the finite element method (FEM).
Changes in Soil Arthropod Abundance and Community Structure across a Poplar Plantation Chronosequence in Reclaimed Coastal Saline Soil
Authors: Li Yuanyuan , Chen Han Y. H. , Song Qianyun , Liao Jiahui , Xu Ziqian , Huang Shide , Ruan Honghua
Published: October 2018

Poplar plantations have the capacity to improve the properties of soils in muddy coastal areas; however, our understanding of the impacts of plantation development on soil arthropods remains limited. For this study, we determined the community dynamics of soil dwelling arthropods across poplar plantations of different ages (5-, 10-, and 21-years) over the course of one year in Eastern Coastal China. The total abundance of soil arthropods differed with stand development. Further, there were some interactions that involved the sampling date. On average, total abundance was highest in the 10-year-old stands and lowest in the 5-year-old stands. Total abundance exhibited strong age-dependent trends in June and September, but not in March or December. The abundance of Prostigmata and Oribatida increased in the 5- to 21-year-old stands, with the highest levels being in the 10-year-old stands. The abundance of Collembola increased with stand development; however, the stand age had no significant impact on the abundance of epedapic, hemiedaphic, and euedaphic Collembola. Order richness (Hill number q = 0) curve confidence intervals overlapped among three stand ages. Shannon and Simpson diversity (Hill numbers q = 1 and q = 2) differed between 10- and 21-year-old stand age. They showed almost similar trends, and the highest and lowest values were recorded in the 21- and 10-year-old stand ages, respectively. Permutational multivariate analysis of variance demonstrated that composition also varied significantly with the sampling date and stand age, and the 10-year-old stands that were sampled in June stood well-separated from the others. Indicator analysis revealed that Scolopendromorpha and Prostigmata were indicators in June for the 10-year-old stands, while Collembola were indicators for the 21-year-old stands sampled in September. Our results highlight that both stand development and climate seasonality can significantly impact soil arthropod community dynamics in the reclaimed coastal saline soils of managed poplar plantations.
Population Structure, Genetic Diversity, and Gene Introgression of Two Closely Related Walnuts (Juglans regia and J. sigillata) in Southwestern China Revealed by EST-SSR Markers
Authors: Yuan Xiao-Ying , Sun Yi-Wei , Bai Xu-Rong , Dang Meng , Feng Xiao-Jia , Zulfiqar Saman , Zhao Peng
Published: October 2018

The common walnut (Juglans regia L.) and iron walnut (J. sigillata Dode) are well-known economically important species cultivated for their edible nuts, high-quality wood, and medicinal properties and display a sympatric distribution in southwestern China. However, detailed research on the genetic diversity and introgression of these two closely related walnut species, especially in southwestern China, are lacking. In this study, we analyzed a total of 506 individuals from 28 populations of J. regia and J. sigillata using 25 EST-SSR markers to determine if their gene introgression was related to sympatric distribution. In addition, we compared the genetic diversity estimates between them. Our results indicated that all J. regia populations possess slightly higher genetic diversity than J. sigillata populations. The Geostatistical IDW technique (HO, PPL, NA and PrA) revealed that northern Yunnan and Guizhou provinces had high genetic diversity for J. regia while the northwestern Yunnan province had high genetic diversity for J. sigillata. AMOVA analysis revealed that significant genetic variation was mainly distributed within population as 73% in J. regia and 76% in J. sigillata. The genetic differentiation (FST) was 0.307 between the two walnut species (p < 0.0001), which was higher than FST values within populations (J. regia FST = 0.265 and J. sigillata FST = 0.236). However, the STRUCTURE analysis of the J. regia and J. sigillata populations revealed two genetic clusters in which gene introgression exists, therefore, the boundary of separation between these two walnut species is not clear. Moreover, these results were validated by NJ and UPGMA analysis with additional conformation from the PCoA. Based on the SSR data, our results indicate that J. sigillata is an ecotype of J. regia. Taken together, these results reveal novel information on population genetics and provide specific geographical regions containing high genetic diversity of the Juglans species sampled, which will assist in future conservation management.
Use of Ginger Nanofibers for the Preparation of Cellulose Nanocomposites and Their Antimicrobial Activities
Authors: Jacob Joby , Haponiuk Józef , Thomas Sabu , Peter Gregary , Gopi Sreeraj
Published: October 2018

Ginger residues left after the extraction of active ingredients from ginger rhizomes are considered to be a bio-waste, available in abundance and very rarely used. Extraction and isolation of natural nanofibers from the agro-waste is economical, environmentally benign, and an alternate strategy to replace synthetic fibers. Here, we report, for the first time, the isolation of ginger nanofibers (GNF) from ginger rhizomes spent by acid hydrolysis and followed by high-pressure homogenization. Scanning electron microscopy was utilized to identify the surface morphology of the GNF and the widths ranged between 130 to 200 nm. Structural analysis of GNF was identified by Fourier transform infrared spectroscopy, Differential scanning calorimetry, and X-ray diffraction methods. This GNF was used to make natural nanocomposites by the solvent-casting method reinforcement, using potato starch (PS) and tapioca starch (TS), and was characterized through various methods. These composites were prepared by the addition of 1, 3, 5, and 7 weight % of GNF with PS or TS. Among these, 5% of the GNF composites of these starches showed very high mechanical properties. The antibacterial test showed that the bionanocomposites with 5% GNF exhibited good antibacterial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium, due to the addition of GNF in the biopolymer matrices. The viable use of GNF from the unexploited ginger agro-waste would create additional profit and it would help to diminish a large amount of waste generation. Thus, the developed bio-composite could also be employed for development of packing materials and be used in medical applications, such as wound healing pads and medical disposables.
Landslide Disasters Triggered by Extreme Rainfall Events: The Case of Montescaglioso (Basilicata, Southern Italy)
Authors: Lazzari Maurizio , Piccarreta Marco
Published: October 2018

We present the results of the study of a large and rapid landslide disaster event, which occurred in Montescaglioso, southern Italy, on 3 December 2013. The studied landslide developed following extreme rainfalls in a zone characterized by a stabilized paleo-landslide body and anthropized in time, filling some streams of the original hydrographic network. The morpho-topographic setting characterizing the slope before the new landslide, has showed, in fact, a substantial stability confirmed also by the application of SINMAP (Stability Index MAPping) analysis. Nevertheless, heavy rains and floods caused a powerful and spectacular landslide event because of the anthropic removal of the old drainage network, which has caused the heaviness of the slope located upstream of the 20 collapsed buildings and along the ill-drained quick-road, built transversely to the slope.
Assessment of Water Quality Profile Using Numerical Modeling Approach in Major Climate Classes of Asia
Authors: Iqbal Muhammad Mazhar , Shoaib Muhammad , Farid Hafiz Umar , Lee Jung Lyul
Published: October 2018

A river water quality spatial profile has a diverse pattern of variation over different climatic regions. To comprehend this phenomenon, our study evaluated the spatial scale variation of the Water Quality Index (WQI). The study was carried out over four main climatic classes in Asia based on the Koppen-Geiger climate classification system: tropical, temperate, cold, and arid. The one-dimensional surface water quality model, QUAL2Kw was selected and compared for water quality simulations. Calibration and validation were separately performed for the model predictions over different climate classes. The accuracy of the water quality model was assessed using different statistical analyses. The spatial profile of WQI was calculated using model predictions based on dissolved oxygen (DO), biological oxygen demand (BOD), nitrate (NO3), and pH. The results showed that there is a smaller longitudinal variation of WQI in the cold climatic regions than other regions, which does not change the status of WQI. Streams from arid, temperate, and tropical climatic regions show a decreasing trend of DO with respect to the longitudinal profiles of main river flows. Since this study found that each climate zone has the different impact on DO dynamics such as reaeration rate, reoxygenation, and oxygen solubility. The outcomes obtained in this study are expected to provide the impetus for developing a strategy for the viable improvement of the water environment.
Association between Smoking Behavior Patterns and Glycated Hemoglobin Levels in a General Population
Authors: Choi Dong-Woo , Jeon Jooeun , Lee Sang Ah , Han Kyu-Tae , Park Eun-Cheol , Jang Sung-In
Published: October 2018

This study investigated the association of smoking behaviors, including dual smoking (smoking both cigarettes and e-cigarettes), cigarettes smoking, and previous smoking, with glycated hemoglobin (HbA1c) levels. National Health and Nutrition Examination Survey (KNHANES) data from 2014–2016 was used. Associations between smoking behavior patterns and HbA1c levels were analyzed via multiple regression. Among 8809 participants, individuals who were dual smokers and cigarettes smokers had significantly higher HbA1c levels than non-smokers (dual: β = 0.1116, p = 0.0012, single: β = 0.0752, p = 0.0022). This relationship strengthened in subgroups of men (dual: β = 0.1290, p = 0.0013, single: β = 0.1020, p = 0.0014, ex: β = 0.0654, p = 0.0308), physically inactive subjects (dual: β = 0.1527, p = 0.0053, single: β = 0.0876, p = 0.0197), and overweight (dual: β = 0.1425, p = 0.0133) and obese individuals (dual: β = 0.1694, p = 0.0061, single: β = 0.1035, p = 0.0217). This study suggests that smoking behaviors are likely to increase the risk of HbA1c level in a general population. The health effects of dual smoking remain uncertain and should be addressed in the future.
Sex-Dependent Impact of Low-Level Lead Exposure during Prenatal Period on Child Psychomotor Functions
Authors: Polanska Kinga , Hanke Wojciech , Pawlas Natalia , Wesolowska Ewelina , Jankowska Agnieszka , Jagodic Marta , Mazej Darja , Dominowska Jolanta , Grzesiak Mariusz , Mirabella Fiorino , Chiarotti Flavia , Calamandrei Gemma
Published: October 2018

The impact of exposure to lead on child neurodevelopment has been well established. However, sex differences in vulnerability are still not fully explained. We aimed at evaluating the effect of a low-level lead exposure, as measured between 20 to 24 weeks of pregnancy and in cord blood, on developmental scores up to 24 months of age in 402 children from the Polish Mother and Child Cohort (REPRO_PL). Additionally, sex-dependent susceptibility to lead at this very early stage of psychomotor development was assessed. The blood lead levels were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). In order to estimate the children’s neurodevelopment, the Bayley Scales of Infant and Toddler Development was applied. The geometric mean (GM) for blood lead level during 20–24 weeks of pregnancy was 0.99 ± 0.15 µg/dL and, in the cord blood, it was 0.96 ± 0.16 µg/dL. There was no statistically significant impact of lead exposure during prenatal period on the girls’ psychomotor abilities. Among the boys, we observed lower scores for cognitive functions, along with increasing cord blood lead levels (β = −2.07; p = 0.04), whereas the results for the language and motor abilities were not statistically significant (p > 0.05). Our findings show that fetal exposure to very low lead levels might affect early cognitive domain, with boys being more susceptible than girls. Education on health, higher public awareness, as well as intervention programs, along with relevant regulations, are still needed to reduce risks for the vulnerable population subgroups.
Seroreactivity and Risk Factors Associated with Coxiella burnetii Infection among Cattle Slaughterhouse Workers in South Korea
Authors: Park Ji-Hyuk , Hwang Seon Do , Acharya Dilaram , Lee Seung Hun , Hwang Kyu Jam , Yoo Seok-Ju , Lee Kwan
Published: October 2018

Q fever, caused by Coxiella burnetii, is a zoonotic disease that is an occupational hazard to people who work in close contact with animals or their carcasses. A nationwide serologic study among cattle slaughterhouse workers who were presumed to be at risk of having C. burnetii infection in South Korea was performed to investigate the seroreactivity of C. burnetii infection and identify related risk factors. Out of 1017 cattle slaughterhouse workers in South Korea, 923 (90.8%) participated in this cross-sectional study. Samples were tested for immunoglobulin G (IgG) and M (IgM) antibodies against phase II C. burnetii via indirect immunofluorescence assay. The overall seroreactivity, defined as IgG or IgM antibody titer cutoffs ≥1:16, was 9.1% (84/923). Additionally, a significant association was found between the seroreactivity of C. burnetii infection and performing carcass evisceration work (odds ratio, 2.36; 95% confidence interval, 1.39–4.03) in multivariate analysis. To diminish C. burnetii infection, cattle slaughterhouse workers need to take precautions during the evisceration process.
Prediction and Decomposition of Efficiency Differences in Chinese Provincial Community Health Services
Authors: Liu Qian , Li Bo , Mohiuddin Muhammad
Published: October 2018

The objective of this paper is to analyze the provincial efficiency of the Chinese community health care service and its differences. This study allows us to predict the provincial differences in the efficiency of the Chinese community health care service from 2017 to 2026. This study analyzes the contributions of inter-regional and intra-regional differences in the total efficiency difference. We use the Super-SBM (Slacks-based Model) data envelopment analysis (DEA) model, Grey Model GM (1,1) for grey prediction, and the group-based Theil index decomposition method to study Chinese provincial panel data from 2008 to 2016. Results show that a fluctuating trend existed in the average provincial efficiency of community health services from 2008 to 2016. The community health services in a considerable number of provincial areas were inefficient. This study also reveals that there existed apparent inter-provincial differences in efficiency in Chinese community health services. The inter-provincial differences of the efficiency of Chinese community health services revealed by the Theil index declined at a relatively slow pace. With regard to the provincial efficiency difference of the Chinese community health service, the intra-regional efficiency difference is the most important structural reason for the overall efficiency difference, which explains the overall difference to a large extent. The inter-regional efficiency difference among the eastern, central, and western regions becomes the secondary structural reason, which should not be ignored. In conclusion, focus should be put on restructuring the investments into medical resources for community health service in each Chinese province. More attentions should be put into narrowing the inter-regional efficiency differences of the Chinese provincial community health service. The strategies targeted at reducing the inter-regional efficiency differences should not be ignored, so as to facilitate the improvement of overall efficiency of the Chinese community health service.
An Improved Progressive TIN Densification Filtering Method Considering the Density and Standard Variance of Point Clouds
Authors: Dong Youqiang , Cui Ximin , Zhang Li , Ai Haibin
Published: October 2018

The progressive TIN (triangular irregular network) densification (PTD) filter algorithm is widely used for filtering point clouds. In the PTD algorithm, the iterative densification parameters become smaller over the entire process of filtering. This leads to the performance—especially the type I errors of the PTD algorithm—being poor for point clouds with high density and standard variance. Hence, an improved PTD filtering algorithm for point clouds with high density and variance is proposed in this paper. This improved PTD method divides the iterative densification process into two stages. In the first stage, the iterative densification process of the PTD algorithm is used, and the two densification parameters become smaller. When the density of points belonging to the TIN is higher than a certain value (in this paper, we define this density as the standard variance intervention density), the iterative densification process moves into the second stage. In the second stage, a new iterative densification strategy based on multi-scales is proposed, and the angle threshold becomes larger. The experimental results show that the improved PTD algorithm can effectively reduce the type I errors and total errors of the DIM point clouds by 7.53% and 4.09%, respectively, compared with the PTD algorithm. Although the type II errors increase slightly in our improved method, the wrongly added objective points have little effect on the accuracy of the generated DSM. In short, our improved PTD method perfects the classical PTD method and offers a better solution for filtering point clouds with high density and standard variance.
The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells
Authors: Lobb Richard J. , Jacobson Gregory M. , Cursons Ray T. , Jameson Michael B.
Published: October 2018

Selenium, a trace element with anticancer properties, can reduce harmful toxicities of chemotherapy and radiotherapy without compromising efficacy. However, the dose-response relationship in normal versus malignant human cells is unclear. We evaluated how methylseleninic acid (MSA) modulates the toxicity and efficacy of chemotherapy and radiation on malignant and non-malignant human mononuclear blood cells in vitro. We specifically investigated its effects on endoplasmic reticulum stress induction, intracellular glutathione concentration, DNA damage and viability of peripheral blood mononuclear cells and THP1 monocytic leukaemia cells in response to radiation, cytosine arabinoside or doxorubicin chemotherapy. MSA, at lower concentrations, induced protective responses in normal cells but cytotoxic effects in malignant cells, alone and in conjunction with chemotherapy or radiation. However, in normal cells higher concentrations of MSA were directly toxic and increased the cytotoxicity of radiation but not chemotherapy. In malignant cells higher MSA concentrations were generally more effective in combination with cancer treatments. Thus, optimal MSA concentrations differed between normal and malignant cells and treatments. This work supports clinical reports that selenium can significantly reduce dose-limiting toxicities of anticancer therapies and potentially improve efficacy of anticancer treatments. The optimal selenium compound and dose is not yet determined.
Exploring Configuration Space and Path Space of Biomolecules Using Enhanced Sampling Techniques—Searching for Mechanism and Kinetics of Biomolecular Functions
Authors: Fujisaki Hiroshi , Moritsugu Kei , Matsunaga Yasuhiro
Published: October 2018

To understand functions of biomolecules such as proteins, not only structures but their conformational change and kinetics need to be characterized, but its atomistic details are hard to obtain both experimentally and computationally. Here, we review our recent computational studies using novel enhanced sampling techniques for conformational sampling of biomolecules and calculations of their kinetics. For efficiently characterizing the free energy landscape of a biomolecule, we introduce the multiscale enhanced sampling method, which uses a combined system of atomistic and coarse-grained models. Based on the idea of Hamiltonian replica exchange, we can recover the statistical properties of the atomistic model without any biases. We next introduce the string method as a path search method to calculate the minimum free energy pathways along a multidimensional curve in high dimensional space. Finally we introduce novel methods to calculate kinetics of biomolecules based on the ideas of path sampling: one is the Onsager–Machlup action method, and the other is the weighted ensemble method. Some applications of the above methods to biomolecular systems are also discussed and illustrated.
Ciprofloxacin Enhances TRAIL-Induced Apoptosis in Lung Cancer Cells by Upregulating the Expression and Protein Stability of Death Receptors through CHOP Expression
Authors: Lim Eun Jin , Yoon Yu Jeong , Heo Jeonghoon , Lee Tae Hwa , Kim Young-Ho
Published: October 2018

Ciprofloxacin (CIP) is a potent antimicrobial agent with multiple effects on host cells and tissues. Previous studies have highlighted their proapoptotic effect on human cancer cells. The current study showed that subtoxic doses of CIP effectively sensitized multiple cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Although TRAIL alone mediated the partial proteolytic processing of procaspase-3 in lung cancer cells, co-treatment with CIP and TRAIL efficiently restored the complete activation of caspases. We found that treatment of lung cancer with CIP significantly upregulated the expression and protein stability of death receptor (DR) 5. These effects were mediated through the regulation of transcription factor CCAT enhancer-binding protein homologous protein (CHOP) since the silencing of these signaling molecules abrogated the effect of CIP. Taken together, these results indicated that the upregulation of death receptor expression and protein stability by CIP contributed to the restoration of TRAIL-sensitivity in lung cancer cells.
Therapeutic Strategies for Spinal Cord Injury
Authors: Jendelova Pavla
Published: October 2018

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Patient- and Surgery-Related Factors that Affect Patient-Reported Outcomes after Total Hip Arthroplasty
Authors: Kawai Toshiyuki , Kataoka Masanao , Goto Koji , Kuroda Yutaka , So Kazutaka , Matsuda Shuichi
Published: October 2018

Patient-reported outcome measures (PROMs) are used to assess satisfaction after total hip arthroplasty (THA); however, the factors that determine these PROMs remain unclear. This study aimed to identify the patient- and surgery-related factors that affect patient satisfaction after THA as indicated by the Oxford Hip Score (OHS). One-hundred-and-twenty patients who underwent primary THA were included. Various patient-related factors, including clinical scores, and surgery-related factors were examined for potential correlations with the OHS at 3, 6, and 12 months post-THA. Univariate regression analysis showed that higher preoperative University of California Los Angeles (UCLA) activity score (p = 0.027) and better preoperative OHS (p = 0.0037) were correlated with better OHS at 3 months post-THA. At 6 months post-THA, the factors associated with better OHS were higher preoperative UCLA activity score (p = 0.039), better preoperative OHS (p = 0.0006), and use of a cemented stem (p = 0.0071). At 12 months post-THA, the factors associated with better OHS were higher preoperative UCLA activity score (p = 0.0075) and better preoperative OHS (p < 0.0001). Multivariate regression analysis showed that the factors significantly correlated with better OHS were female sex (p = 0.011 at 3 months post-THA), osteoarthritis (p = 0.043 at 6 months), higher preoperative OHS (p < 0.001 at 3 and 12 months, p = 0.018 at 6 months), higher preoperative Harris Hip Score (p = 0.001 at 3 months), higher preoperative UCLA activity score (p = 0.0075 at 3 months), and the use of a cemented femoral component (p = 0.012 at 6 months). Patient- and surgery-related factors affecting post-THA PROMs were identified, although the effect of these factors decreased over time.
Impaired Executive Functioning of Sexual Assault Survivors with Acute Stress Disorder
Authors: Park Su , Choi Jung-Seok , Lee Ji , Lee Jun-Young , Lee Saerom , Jung Hee
Published: October 2018

This study aimed to examine the executive functioning of survivors exposed to recent sexual assaults. Twenty-seven female rape survivors who met the criterion for acute stress disorder (ASD) were enrolled and completed the assessment within 4 weeks after the traumatic experience. Additionally, 25 age-matched female health controls (HC) never exposed to such a traumatic event were enrolled. The assessments evaluated psychiatric symptoms including post-traumatic stress symptoms, depression, anxiety, and trait and state anger; general intelligence indexed by intellectual quotient (IQ); and executive functioning including set-shift/attention, planning, spatial working memory, and inhibition using the Cambridge Neuropsychological Test Automated Battery. The ASD group showed higher levels of depression, anxiety, and state anger, and lower IQ than the HC group. The ASD group also showed global impairment of executive functioning for set-shifting, attention, planning, and response inhibition compared to the HC group. Rather than being associated with low IQ and education levels, these results could be from trauma-related effects in survivors with ASD. Additionally, the state anger level was related to survivors’ deficient executive functioning. The findings indicate the importance of providing assessment and intervention efforts to sexual assault survivors soon after the trauma occurs.
Nebulised N-Acetylcysteine for Unresponsive Bronchial Obstruction in Allergic Brochopulmonary Aspergillosis: A Case Series and Review of the Literature
Authors: Otu Akaninyene , Langridge Philip , Denning David W.
Published: October 2018

Many chronic lung diseases are characterized by the hypersecretion of mucus. In these conditions, the administration of mucoactive agents is often indicated as adjuvant therapy. N-acetylcysteine (NAC) is a typical example of a mucolytic agent. A retrospective review of patients with pulmonary aspergillosis treated at the National Aspergillosis Centre in Manchester, United Kingdom, with NAC between November 2015 and November 2017 was carried out. Six Caucasians with Aspergillus lung disease received NAC to facilitate clearance of their viscid bronchial mucus secretions. One patient developed immediate bronchospasm on the first dose and could not be treated. Of the remainder, two (33%) derived benefit, with increased expectoration and reduced symptoms. Continued response was sustained over 6–7 months, without any apparent toxicity. In addition, a systematic review of the literature is provided to analyze the utility of NAC in the management of respiratory conditions which have unresponsive bronchial obstruction as a feature.
The Effect of Surface Texturing on Dry Gross Fretting
Authors: Lenart Agnieszka , Pawlus Pawel , Wos Slawomir , Dzierwa Andrzej
Published: October 2018

The effect of steel disc surface texturing on dry gross fretting in a ball-on-disc configuration was studied. Dimples were created with abrasive jet machining. The tribological performance of sliding pairs, steel–steel and steel–ceramics, was experimentally studied. The character of surface texturing effect was related to the dominant wear type. During steel–steel contact, the presence of dimples on disc surfaces could lead to increases in wear and friction. However, the escape of wear debris into dimples could result in reductions of friction and wear in the steel–ceramics configuration.
Photocatalytic Activity: Experimental Features to Report in Heterogeneous Photocatalysis
Authors: Hoque Md. Ariful , Guzman Marcelo I.
Published: October 2018

Heterogeneous photocatalysis is a prominent area of research with major applications in solar energy conversion, air pollution mitigation, and removal of contaminants from water. A large number of scientific papers related to the photocatalysis field and its environmental applications are published in different journals specializing in materials and nanomaterials. However, many problems exist in the conception of papers by authors unfamiliar with standard characterization methods of photocatalysts as well as with the procedures needed to determine photocatalytic activities based on the determination of “apparent quantum efficiencies” within a wavelength interval or “apparent quantum yields” in the case of using monochromatic light. In this regard, an astonishing number of recent research articles include claims of highly efficient (photo)catalysts or similar terms about materials with superior or enhanced efficiency for a given reaction without proper experimental support. Consequently, the comparison of the efficiencies of photocatalysts may result as being meaningless, especially when reports are only based on expressions determining (1) a reaction rate per weight of catalyst or its surface area, (2) quantum efficiencies or quantum yields, and (3) turnover frequencies or turnover numbers. Herein, we summarize the standards needed for reporting valuable data in photocatalysis and highlight some common discrepancies found in the literature. This work should inform researchers interested in reporting photocatalysis projects about the correct procedures for collecting experimental data and properly characterizing the materials by providing examples and key supporting literature.
Experimental Study on Bi-Axial Mechanical Properties of Warp-knitted Meshes with and without Initial Notches
Authors: Shao Huiqi , Li Jianna , Chen Nanliang , Shao Guangwei , Jiang Jinhua , Yang Youhong
Published: October 2018

Warp-knitted meshes have been widely used for structural reinforcement of rigid, semi-rigid, and flexible composite materials. In order to meet the performance requirements of different engineering applications, four typical warp-knitted meshes (rectangular, square, circular, and diamond) were designed and developed. The mechanical behaviors of these meshes under mono-axial and multi-axial tensile loads were compared. The influence of the initial notch length and orientation on the mechanical performance was also analyzed. The results showed that the biaxial tensile behavior of warp-knitted meshes tended to be more isotropic. The anisotropy level of the diamond warp-knitted mesh was the lowest (λ = 0.099), while the rectangular one was the highest (λ = 0.502). The notch on a significantly anisotropic mesh was propagated along the direction of larger modulus, while for a not remarkably anisotropic mesh, notch propagation was probably consistent with the initial notch orientation. The breaking strength of warp-knitted meshes with the same initial notch orientation decreased with the increase in notch length in both the wale and course directions. For warp-knitted meshes with the same initial notch length, the breaking strength in the wale direction was kept stable at different notch orientations, while that in the course direction decreased remarkably with notch orientation from 0° to 90°.
Electric Current Dependent Fracture in GaN Piezoelectric Semiconductor Ceramics
Authors: Qin Guoshuai , Lu Chunsheng , Zhang Xin , Zhao Minghao
Published: October 2018

In this paper, the fracture behavior of GaN piezoelectric semiconductor ceramics was investigated under combined mechanical and electric loading by using three-point bending tests and numerical analysis. The experimental results demonstrate that, in contrast to traditional insulating piezoelectric ceramics, electric current is a key factor in affecting the fracture characteristics of GaN ceramics. The stress, electric displacement, and electric current intensity factors were numerically calculated and then a set of empirical formulae was obtained. By fitting the experimental data, a fracture criterion under combined mechanical and electrical loading was obtained in the form of an ellipsoid function of intensity factors. Such a fracture criterion can be extended to predict the failure behavior of other piezoelectric semiconductors or devices with a crack, which are useful in their reliability design and applications.
Standard Reference Materials for Cement Paste: Part III—Analysis of the Flow Characteristics for the Developed Standard Reference Material According to Temperature Change
Authors: Lee Dong Kyu , Choi Myoung Sung
Published: October 2018

For the general quantitative evaluation of the flow characteristics of a material, various factors that affect the flow should be examined. Notably, cement paste shows multi-dimensional flow characteristics owing to not only its inherent features such as its various particle sizes and hydration reaction, but also due to environmental factors including temperature, humidity, and pressure. Therefore, an analysis of those environmental factors is important for the quantitative evaluation of the flow characteristics of cement paste. In this study, we analyzed the flow characteristics of cement paste and a newly developed standard reference material (SRM) that has similar flow characteristics to cement paste at different temperatures. For the analysis, the flow characteristics of each cement paste mixture at five different temperatures (5 °C, 10 °C, 20 °C, 30 °C, and 40 °C) were examined, in consideration of variations in construction environments. Then, the flow characteristics of the developed SRM at different temperatures were also analyzed. The result of the analysis demonstrated a decrease in the rheology constant value following a rise in the temperature. Notably, the degree of variation in the flow characteristics was larger at a lower temperature, while flow characteristics remained nearly constant at higher temperatures. The result of the analysis also confirmed that cement paste and the newly developed SRM displayed similar tendencies for the change in flow characteristics following a change in temperature. In conclusion, the newly developed SRM is thought to be useful for consistently representing the flow characteristics of cement paste under various construction environments in consideration of temperature change.
Synthesis and Application of Scaffolds of Chitosan-Graphene Oxide by the Freeze-Drying Method for Tissue Regeneration
Authors: Valencia Cesar , Valencia Carlos H. , Zuluaga Fabio , Valencia Mayra E. , Mina José H. , Grande-Tovar Carlos David
Published: October 2018

Several biomaterials, including natural polymers, are used to increase cellular interactions as an effective way to treat bone injuries. Chitosan (CS) is one of the most studied biocompatible natural polymers. Graphene oxide (GO) is a carbon-based nanomaterial capable of imparting desired properties to the scaffolds. In the present study, CS and GO were used for scaffold preparation. CS was extracted from the mycelium of the fungus Aspergillus niger. On the other hand, GO was synthesized using an improved Hummers-Offemann method and was characterized by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, atomic force microscopy (AFM), X-ray diffraction (XRD), and dynamic light scattering (DLS). Subsequently, three formulations (GO 0%, 0.5%, and 1%) were used to prepare the scaffolds by the freeze-drying technique. The scaffolds were characterized by FTIR, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM), to determine their thermal stability and pore size, demonstrating that their stability increased with the increase of GO amount. Finally, the scaffolds were implanted, recollected 30 days later, and studied with an optical microscope, which evidenced the recovery of the tissue architecture and excellent biocompatibility. Hence, these results strongly suggested the inherent nature of chitosan/graphene oxide (CS/GO) scaffolds for their application in bone tissue regeneration.
Mapping Free Energy Pathways for ATP Hydrolysis in the E. coli ABC Transporter HlyB by the String Method
Authors: Zhou Yan , Ojeda-May Pedro , Nagaraju Mulpuri , Kim Bryant , Pu Jingzhi
Published: October 2018

HlyB functions as an adenosine triphosphate (ATP)-binding cassette (ABC) transporter that enables bacteria to secrete toxins at the expense of ATP hydrolysis. Our previous work, based on potential energy profiles from combined quantum mechanical and molecular mechanical (QM/MM) calculations, has suggested that the highly conserved H-loop His residue H662 in the nucleotide binding domain (NBD) of E. coli HlyB may catalyze the hydrolysis of ATP through proton relay. To further test this hypothesis when entropic contributions are taken into account, we obtained QM/MM minimum free energy paths (MFEPs) for the HlyB reaction, making use of the string method in collective variables. The free energy profiles along the MFEPs confirm the direct participation of H662 in catalysis. The MFEP simulations of HlyB also reveal an intimate coupling between the chemical steps and a local protein conformational change involving the signature-loop residue S607, which may serve a catalytic role similar to an Arg-finger motif in many ATPases and GTPases in stabilizing the phosphoryl-transfer transition state.
Recent Advances in the Catalytic Asymmetric Reactions of Oxaziridines
Authors: Ren Qiao , Yang Wen , Lan Yunfei , Qin Xurong , He Youzhou , Yuan Lujiang
Published: October 2018

Oxaziridines have emerged as powerful and elegant oxygen- and nitrogen-transfer agents for a broad array of nucleophiles, due to the remarkably high and tunable reactivities. However, the asymmetric catalysis involving oxaziridines is still in its infancy. Herein, this review aims to examine recent advances in the catalytic asymmetric transformations of oxaziridines, including oxidation, amination, cycloaddition and deracemization.
Simultaneous Separation and Purification of Five Polymethoxylated Flavones from “Dahongpao” Tangerine (Citrus tangerina Tanaka) Using Macroporous Adsorptive Resins Combined with Prep-HPLC
Authors: Li Zhenqing , Zhao Ziyan , Zhou Zhiqin
Published: October 2018

In this study, a preparative separation method was established to simultaneously isolate the polymethoxylated flavones (PMFs) from the peel of “Dahongpao” tangerine using macroporous adsorptive resins (MARs) combined with prep-HPLC. The total PMFs were enriched using MARs to remove most sugars, water-soluble pigments, and flavanones, and the eluents obtained were analyzed by ultra-performance liquid chromatography (UPLC) to determine the PMF composition. The separation and purification of PMFs were carried out by using a mass spectrometry-guided prep-HPLC with a gradient elution of acetonitrile-water (v/v), simultaneously. The purity of these PMFs was determined by UPLC, and their chemical structures were confirmed by electrospray ionization mass spectrometry (ESI-MS-MS), ultraviolet (UV), and nuclear magnetic resonance (NMR). Using the present method, five PMFs, including 5,6,7,4’-tetramethoxyflavone (1), nobiletin (2), tangeretin (3), sinensetin (4), and 5-hydroxy-6,7,8,3’,4’-pentamethoxyflavone (5), can be purified simultaneously, and the purity of the compounds obtained were 95.3%, 99.7%, 99.5%, 98.9%, and 98.1%, respectively. The method reported here is simple, rapid, and efficient, and it can be used to separate PMFs from citrus fruit peels and, potentially, other plant materials.
Inhibition of a Snake Venom Metalloproteinase by the Flavonoid Myricetin
Authors: Preciado Lina , Comer Jeffrey , Núñez Vitelbina , Rey-Súarez Paola , Pereañez Jaime
Published: October 2018

Most of the snakebite envenomations in Central and South America are caused by species belonging to Bothrops genus. Their venom is composed mainly by zinc-dependent metalloproteinases, responsible of the hemorrhage characteristic of these envenomations. The aim of this study was to determine the inhibitory ability of ten flavonoids on the in-vitro proteolytic activity of Bothrops atrox venom and on the hemorrhagic, edema-forming and myonecrotic activities of Batx-I, the most abundant metalloproteinase isolated from this venom. Myricetin was the most active compound, exhibiting an IC 50 value of 150 μ M and 1021 μ M for the inhibition of proteolytic and hemorrhagic activity, respectively. Independent injection experiments, with a concentration of 1600 μ M of myricetin administered locally, immediately after toxin injection, demonstrated a reduction of 28 ± 6 % in the hemorrhagic lesion. Additionally, myricetin at concentrations 800, 1200 and 1600 μ M promoted a reduction in plasma creatine kinase activity induced by Batx-I of 21 ± 2 % , 60 ± 5 % and 63 ± 2 % , respectively. Molecular dynamics simulations coupled with the adaptive biasing method suggest that myricetin can bind to the metalloproteinase active site via formation of hydrogen bonds between the hydroxyl groups 3’, 4’ and 5’ of the benzyl moiety and amino acid Glu143 of the metalloproteinase. The hydroxyl substitution pattern of myricetin appears to be essential for its inhibitory activity. Based on this evidence, myricetin constitutes a candidate for the development of inhibitors to reduce local tissue damage in snakebite envenomations.
New Antioxidant Multilayer Packaging with Nanoselenium to Enhance the Shelf-Life of Market Food Products
Authors: Vera Paula , Canellas Elena , Nerín Cristina
Published: October 2018

A flexible multilayer with selenium nanoparticles incorporated has been used to build an antioxidant packaging. The oxidation of hazelnuts, walnuts, and potato chips was tested at laboratory scale. Hexanal released by the nuts, fatty acids oxidation study, TBARS (thiobarbituric acid reactive substances), and tasting were compared to study the oxidation of foods packaged with this antioxidant packaging. Finally, TBARS method in combination with tasting were selected due to their simplicity and accuracy. It was found that hazelnuts packaged in nanoSe active bags released around 20% less malonaldehyde (MDA) than the blanks. In the case of the walnuts, the active ones released 25% less MDA than the blanks. As for potato chips, the improvement was around 22%. Finally, an industrial study was done. Cooked ham, chicken, and a ready-to-eat vegetable mixture seasoned with butter were industrially packaged with the new antioxidant material and improvements higher than 25% were obtained.