bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal ischemia-reperfusion-induced metabolic and micro-rheological alterations and their modulation by remote organ ischemic preconditioning protocols in the rat
Authors: Varga Gabor , Ghanem Souleiman , Szabo Balazs , Nagy Kitti , Pal Noemi , Tanczos Bence , Somogyi Viktoria , Barath Barbara , Deak Adam , Peto Katalin , Nemeth Norbert
Published: December 2018

BACKGROUND:

Pathomechanism and optimal renoprotective protocol for remote ischemic preconditioning (RIPC) have not been completely revealed yet.

OBJECTIVE:

To investigate micro-rheological effects of early and delayed RIPC in renal ischemia-reperfusion (I/R) in the rat.

METHODS:

In Control group the left femoral artery was cannulated and the left kidney was gently exposed. In the I/R group 45-minute renal ischemia with 120-minute reperfusion period was monitored. In the RIPC groups a 3×10-minute protocol was applied using tourniquet around the right hind-limb 1 hour (RIPC-1) or 24 hours (RIPC-24) prior to the I/R. Blood samples were taken for testing blood gas, acid-base, metabolic and hemorheological parameters.

RESULTS:

Lactate and potassium concentration significantly increased in I/R that could be reduced by RIPC, especially in RIPC-24. Creatinine concentration increased further in RIPC groups. I/R and RIPC-1 decreased the pH, RIPC-24 increased. RIPC-24 reduced the drop in base excess. Erythrocyte deformability worsened by renal I/R. In RIPC groups deformability decreased additively. However, RIPC-1 could improve the condition. RIPC-24 showed the highest erythrocyte aggregation values during reperfusion.

CONCLUSIONS:

Renal I/R worsened metabolic and micro-rheological parameters that could be modulated by RIPC protocols. However, it could not be decided whether the early or the delayed protocol is better.
Challenges for Optimizing Real-World Evidence in Alzheimer’s Disease: The ROADMAP Project
Authors: Gallacher John , de Reydet de Vulpillieres Frederic , Amzal Billy , Angehrn Zuzanna , Bexelius Christin , Bintener Christophe , Bouvy Jacoline C. , Campo Laura , Diaz Carlos , Georges Jean , Gray Alastair , Hottgenroth Antje , Jonsson Pall , Mittelstadt Brent , Potashman Michele H. , Reed Catherine , Sudlow Cathie , Thompson Robin , Tockhorn-Heidenreich Antje , Turner Andrew , van der Lei Johan , Visser Pieter Jelle ,   the ROADMAP Consortium
Published: December 2018

ROADMAP is a public-private advisory partnership to evaluate the usability of multiple data sources, including real-world evidence, in the decision-making process for new treatments in Alzheimer’s disease, and to advance key concepts in disease and pharmacoeconomic modeling. ROADMAP identified key disease and patient outcomes for stakeholders to make informed funding and treatment decisions, provided advice on data integration methods and standards, and developed conceptual cost-effectiveness and disease models designed in part to assess whether early treatment provides long-term benefit.
Visually-Rated Medial Temporal Lobe Atrophy with Lower Educational History as a Quick Indicator of Amnestic Cognitive Impairment after Stroke
Authors: Takahashi Yukako , Saito Satoshi , Yamamoto Yumi , Uehara Toshiyuki , Yokota Chiaki , Sakai Go , Nishida Norifumi , Takahashi Ryosuke , Kalaria Raj N. , Toyoda Kazunori , Nagatsuka Kazuyuki , Ihara Masafumi
Published: December 2018

Background:

Time and resource limitations prevent cognitive assessment in acute-to-subacute settings, even in comprehensive stroke centers.

Objective:

To assess cognitive function in acute stroke patients undergoing routine clinical, laboratory, and radiological investigations, with a view to improving post-stroke care and treatment.

Methods:

Sixty-nine patients (72.6±11.1 years; 65% male) were prospectively enrolled within 14 days of acute ischemic stroke. Patients with altered consciousness, aphasia, or dysarthria were excluded. Clinical features including modified Rankin and NIH stroke scales, and vascular risk factors were assessed, as well as neuroimaging parameters by semi-quantitative evaluation of medial temporal lobe atrophy (MTLA) using MRA source images, FLAIR images for white matter changes (Fazekas scores), and T2∗ images for cerebral microbleeds. Neuropsychological screening was conducted using the Montreal Cognitive Assessment (MoCA) test. Univariate and multivariate analyses were used to evaluate the influence of variables on MoCA total and subscale scores.

Results:

Lower MoCA scores of 22 or less were associated with MTLA [OR (95% CI), 5.3 (1.0–27.5); p = 0.045], education years [OR (95% CI), 0.71 (0.55–0.91); p = 0.007], and modified Rankin scale at discharge [OR (95% CI), 2.4 (1.3–4.5); p = 0.007]. The delayed recall MoCA score was correlated with MTLA ( r = – 0.452, p < 0.001), periventricular ( r = – 0.273, p = 0.024), and deep ( r = – 0.242, p = 0.046), white matter changes.

Conclusions:

MTLA, together with lower educational history, are quick indicators of amnestic cognitive impairment after stroke. The association between cognitive impairment and physical disability at discharge may signify the importance of earlier cognitive assessment.
Parkinson Diseases in the 2020s and Beyond: Replacing Clinico-Pathologic Convergence With Systems Biology Divergence
Authors: Espay Alberto J. , Lang Anthony E.
Published: December 2018

Parkinson disease has been considered for practical purposes a heterogeneous clinico-pathological entity. The operational definition requires clinical ascertainment of a levodopa-responsive parkinsonism with no “atypical” features, and pathological criteria based on the finding, usually at postmortem, of aggregates of α-synuclein in Lewy bodies and Lewy neurites. The underlying assumption has been that a molecular-biological disorder, targetable for disease modification as a whole, underlies this clinico-pathologic, convergent model of disease. The 2020s will be expected to mark the beginning of the end for this model, especially if therapeutic success in a specific molecular subtype, such as PD-GBA, is not translated to “sporadic PD”. The complex and dynamic biological abnormalities of aging, which have informed the evolution of other fields in medicine into divergent, systems-biology models, will also provide the template for the development of disease modifying therapies for neurodegenerative disorders. In the 2020s and 2030s we will no longer ask whether any given molecule may be neuroprotective in early Parkinson disease but, rather, which subtype (which endophenotype) among the Parkinson diseases would be the best mechanistic recipient for such molecule and which would not. The next breakthrough in Parkinson’s research will be conceptual: the recognition that discoveries in a subtype of PD will apply only or largely to that subtype and not construed to represent “a piece” that seamlessly inserts into, and helps explains, a unifying “Parkinson’s puzzle”. Successful neuroprotection for each PD subtype will likely require pharmacotherapeutic combinations (“drug cocktails”) to harness synergistic potential benefits when more than the dominant pathogenic mechanism is targeted, as identified from forthcoming population-based unbiased biomarker discovery programs.
The Future of Surgical Treatments for Parkinson’s Disease
Authors: Lee Darrin J. , Lozano Andres M.
Published: December 2018

The surgical treatment of Parkinson’s disease has made significant progress over the past 70 years; however, its scope of effectiveness remains limited to motor symptoms like bradykinesia, rigidity, tremor and medication-induced dyskinesias. The field of surgery initially developed from lesioning procedures and then transitioned largely to deep brain stimulation due to its properties of adaptability and reversibility. Interestingly, there has been a renewed interest in lesioning procedures secondary to the introduction of focused ultrasound, a non-invasive technology. Despite the various current therapies’ effectiveness, there is a significant need for developing treatments to modify the disease process itself. To date, gene therapy, immunotherapy, and cell transplantation trials have had both promising and disappointing results. Newer techniques being developed (optogenetics, magnetogenetics, and sonogenetics) are exciting possibilities for the future. Here, we examine and speculate on novel potential surgical treatments for Parkinson’s disease.
Therapies to Slow, Stop, or Reverse Parkinson’s Disease
Authors: Foltynie Tom , Langston J. William
Published: December 2018

Our understanding of PD pathophysiology is vastly improved compared to the situation 20 years ago. We have identified the major genetic risks for PD, we now have far more representative animal models of the disease, and we can be inspired by the early successes of others using Antisense Oligonucleotide and vaccination approaches in other neurodegenerative diseases. We also have a broad range of repurposed drugs showing the first signals of potential efficacy in the translational pipeline which are being driven forward through the various clinical trial stages. We believe we can be optimistic that the next 20 years will be a time for major breakthroughs towards the discovery of therapies that may slow, stop, or reverse PD.
Optimization of agglomeration burdens by metallugical properties complex. Report 1. Optimization of agglomeration burdens by technological characteristics of sinter production
Authors: D’yakov A. V. , Odintsov A. A. , Kobelev V. A. , Nechkin G. A.
Published: December 2018

Despite a lot of studies of iron ore raw materials was carried out both in sinter and BF production areas, the matter of agglomeration burdens optimization is still actual. Laboratory studies on sintering of agglomeration burdens of different component content were carried out for optimization of iron ore burden content optimization, following by determination of technology characteristics and metallurgical properties complex.

As a result of the studies an optimal component and size content of the agglomeration burden determined to provide improving of metallurgical properties complex of agglomeration burden. The studies carried out showed, that lime introducing into the concentrate flow before the burden department can lead to sintering machines productivity increasing.

The burden wetness range determined, enabling for complete lime hydrating. It was shown, that a partial replacement of agglomeration ores in the burden by BOF nickel slag contributes to agglomeration process specific productivity increasing as well as sinter strength increasing.
Technical solutions for efficiency increasing of blast furnace casting yards aspiration
Authors: Stefanenko V. T. , Stefanenko A. V. , Popova N. P.
Published: December 2018

Casting yards of blast furnaces are most powerful sources of atmospheric air pollution among big non-organized pollution sources of steel industry. The task to create effective systems of those sources aspiration is rather actual.

Analysis of known technical solutions on blast furnace casting yards aspiration presented. Positive and negative sides of the projects determined. A conclusion made that aspiration systems effectiveness is determined by designs of local suction facilities and covers for localization of emitted dust and gas convection flows. Main directions of effective aspiration system creation formulated. At the example of JSC MMK BFs No. 9 and No. 10, four variants of technical solutions of general aspiration system for casting yards quoted, accompanied by calculation of convection flows and emissions volumes, maximum necessary productivity of aspiration facility and aero dynamical calculation of an aspiration system. Plan and algorithms of the system valves operation studied. Effectiveness of localization (capture degree) of non-organized emissions estimated as about 90%.
A new technology for production of precision pipes for ionizing radiation sources
Authors: Serebryakov An. V. , Serebryakov Al. V. , Parshakov S. I.
Published: December 2018

Precision pipes made of corrosion-resistant steel are used for manufacturing sources of ionizing radiation. The accuracy and stability of the pipe sizes provides the ability to assemble the source design with a remote tool under conditions of technological chambers. Ensuring production of radiation sources by precision domestic tubes is an actual task. The technology of producing pipes for radiation sources has been developed and mastered. The basis of technology is a method of pipes drawing on a mandrel. The novelty of the proposed method is the use of a tool made of a material with certain physical properties. To illustrate the possibilities of the new technology, the results of a statistical analysis of dimensions of the outer and inner diameters, as well as the roughness of the outer surface of the pipes, are presented. It is established that the new technology provides the required level of dimensional accuracy and surface quality of pipes for radiation sources.
Comparative technological analysis of control systems of blast furnace hearth lining deterioration
Authors: Dmitriev A. N. , Zolotykh M. O. , Chen' K. , Vit'kina G. Yu.
Published: December 2018

For safe and effective operation of a blast furnace it is important to know the residual thickness of the blast furnace hearth lining any time, first of all the location of the damaged arears. Use of traditional methods of hearth and bottom lining control often lead to a mistaken diagnostics.

Institute of metallurgy of Ural branch of RussianacademyofScienceselaborated a mathematical model, providing a 3-dimentional estimation of the lining status and optimization of calculations for operation in real time mode.

The calculation is done by solving equations of heat conductivity by usage of a number of temperature sensors (up to 700), implemented into furnace lining between refractory blocks. Calculation algorithm was modified by application of sampling theorem to take into account the complex profile of the blast furnace lower part. A system of information collection, processing and passing used from the sensors to program data base. A continuous control of temperature variation in every point enables to determine a current lining refractory thickness and notify the furnace personal in advance about beginning of the lining erosion. The elaborated program interface enables the furnace foreman to use additional control functions, in particular, the residual lining thickness, including: direct visualization of the status and tendencies of the erosion change, temperature distribution in every point of the lining at computer monitor, signaling about dangerous zone; volume temperature distribution (isotherms) and tendencies of their changes. The interface languages available as following: Chinese, English, Russian.
Development of technologies with a purpose of increasing of metallurgical properties of Kachkanar pellets
Authors: Yur’ev B. P. , Dudko V. A.
Published: December 2018

A blast furnace technology developed, using equally basicity Kachkanar iron ore raw materials. Research work carried out to study gas media content and pellets basicity influence on their structure and metallurgical properties, as well as basicity and fuel content in the burden influence on metallurgical properties and structure of sinter. It was determined, that usage of low basicity pellets and high basicity sinter with weak rupture during reduction, provide a high gas penetrability in the upper horizons of blast furnace.

It was shown, that presence of amphoteric titanium oxides and aluminum in Kachkanar sinter and pellets, as well as decrease of slope angle of the shaft in blast furnace prevents the early sticking of burden materials in the lower horizons of the furnace, that provides smooth burden lowering, high degree of gas reduction potential usage and thus the increase of the furnace productivity as well as coke rate decrease.

An analysis of the work to optimize the technology of pellets production of Kachkanar concentrates made. It was determined, that an increase of the pellets quality can be reached as a result of implementation of a technology of their roasting with a partial dissociation of hematite. A complex estimation of metallurgical properties of partially dissociated pellets carried out. It was shown, that the pellets with hematite-magnetite structure, being a result of partial dissociation of hematite, are reduced at higher temperatures, when their intensive swell and rupture at the stage of hematite-into-magnetite transfer do not happen.
Deoxidizing and modifying properties of alkaline earth metals within ferroalumosilicocalcium and ferrosilicobarium alloys
Authors: Il’yasov A. E. , Sharkaev S. N. , Akhmetov A. B. , Kusainova G. D. , Yablonsky V. I.
Published: December 2018

Modification of alloys, in particular, by calcium and barium, is one of the promising directions for obtaining alloys with a fine crystalline structure. Complex ferroalloys – ferroalumosilicocalcium and ferrosilicobarium – were developed in the Chemical and Metallurgical Institute after Zh. Abishev. It was shown, that modification of steel by silicon-aluminum complex alloys containing chemically active elements – calcium and barium, should become one of the most effective methods to improve the quality of machine-building metal products.

The chemical compositions of the smelted ferroaluminosiliconcalcium and ferrosilicobarium presented. The melting range of the nonmetallic compound formed during the deoxidation of steel by complex alloy containing calcium determined. Results of mechanical tests of the specimens of steel, modified by a complex alloy containing barium considered. A comparison of microstructure of the current production route steel and deoxidized with the complex alloys was carried out.

In the course of metallographic studies of experimental steel specimens, a modifying influence on the morphology of nonmetallic inclusions by calcium and barium, supplied in a complex with aluminum and silicon alloys, was established.

Metal processing by complex alloys such as ferrosilicoaluminum with calcium (FASC) and ferrosilicobarium (FSAB) indicates the possibility of achieving a higher degree of refining from oxide nonmetallic inclusions and a more even distribution of them in the ingot.

The results of the industrial heats also indicated a possibility of improving of quality of casting through the decreasing of hot thermal cracks and gas-shrinkage defects, cleaner grain boundaries, a significant reduction in the number and size of carbide inclusions.
COMPREENDENDO A SOCIEDADE CIVIL E A ESFERA PÚBLICA POLÍTICA DE HABERMAS
Authors: Marquette Felipe Rotta , Vanzella José Marcos Miné
Published: December 2018

A obra de Habermas é de contribuição ímpar para a compreensão das transformações fundamentais da democracia e da complexa sociedade moderna. Utilizando-se como método a discussão teórica filosófica, este artigo procura compreender qual o papel da sociedade civil e da esfera pública na democracia, segundo o pensamento de Jürgen Habermas. Tem por objetivo investigar o papel autônomo da sociedade civil e a da esfera pública em relação ao Estado, enquanto espaço de exercício e comunicação da liberdade no sistema democrático ligado às garantias jurídicas para dar suporte legitimatório ao exercício da cidadania.
O CONTROLE SOCIAL NO COMBATE À CORRUPÇÃO
Authors: Assis Christiane Costa , Silva Adriana Campos
Published: December 2018

O objetivo do presente artigo consiste em analisar o papel do controle social no combate à corrupção. Para tanto, o trabalho aborda a construção da cidadania por meio da educação em direitos humanos, as ideias de controle social, accountability e transparência e ainda a necessidade de uma reforma política. A metodologia adotada foi composta pelo método de abordagem dialético comparativo, uma vez que se buscou uma conclusão a partir do debate entre diversas posições teóricas, e pelo procedimento da pesquisa bibliográfica, apresentando-se autores selecionados conforme a temática proposta. Como conclusão o presente artigo apontou o controle social como o único mecanismo capaz de afrontar governantes descompromissados com a população.
DECISÃO JUDICIAL E PRODUÇÃO CIENTÍFICA: relações sistêmicas entre Direito e Ciência Jurídica
Authors: Krepsky Giselle Marie
Published: December 2018

Este artigo apresenta uma observação dos Sistemas do Direito e da Ciência a partir da relação entre o que é comunicado cientificamente sobre o Direito e o que é julgado pelo Tribunal de Justiça de Santa Catarina a fim de verificar a capacidade de ressonância da Academia na Dogmática. Observou-se que a exigência Constitucional de fundamentação das decisões reforçada pelo Novo Código de Processo Civil pode fomentar a abertura do Direito para o uso mais sofisticado da Doutrina e da produção acadêmica nas decisões. Concluiu-se que a alta variação temática da produção acadêmico-científica e alta repetição dos julgados possibilita a mera reprodução do Sistema da Ciência.
Proroga ex lege della durata delle concessioni demaniali marittime: tra diritto europeo e nazionale
Authors: Prada Fiorenza
Published: December 2018

La sentenza in esame si concentra sull'annosa questione della compatibilità tra libertà di stabilimento (art. 49 TFUE) e direttiva 2006/123 / CE sulle concessioni marittime demaniali da un lato, e l'estensione automatica di tali concessioni prevista dalla legge italiana dall'altro. La Corte di Giustizia europea nega questa possibilità, ma offre alcuni suggerimenti al legislatore italiano
Web scraping e diritti di proprietà intellettuale nell'intermediazione di biglietti aerei low cost
Authors: Corigliano Alessandra
Published: December 2018

Nella sentenza di seguito commentata, la Corte d'Appello di Milano, in merito alla decisione di Ryanair di escludere qualsiasi intermediazione commerciale nella vendita dei propri biglietti aerei, si è pronunciata nella vertenza tra la compagnia aerea irlandese e l'agenzia di viaggi italiana Viaggiare che, in primo grado, ha denunciato il comportamento di Ryanair in quanto avrebbe ostacolato con il proprio comportamento l'agenzia di viaggio nella vendita dei biglietti aerei di Ryanair direttamente ai consumatori, costringendo l'agenzia stessa a riutilizzare i dati forniti dal database di Ryanair al fine di vendere indirettamente i biglietti sul suo sito web. La Corte (in parziale riforma della sentenza del Tribunale di primo grado) ha ritenuto che la decisione della compagnia aerea di riservarsi la vendita di biglietti aerei non costituisse un abuso di posizione dominante come previsto dall'articolo 102 del Trattato sul Funzionamento dell'Unione Europea, in quanto Ryanair deteneva nel mercato dei voli europei solo il 10%, quota questa molto bassa, che varrebbe a escludere una posizione dominante della compagnia su detto mercato. Nell'ottica della normativa antitrust, è stata accolta la mozione di Ryanair volta ad escludere una posizione dominante sul mercato dei voli europei, mentre nell'ottica dei diritti di proprietà intellettuale la domanda di Ryanair è stata respinta. A questo proposito, la Corte non ha accolto la mozione di Ryanair in base alla quale l'uso dei suoi marchi da parte di Viaggiare violasse i diritti privativi di Ryanair; la Corte ha inoltre stabilito che il database di Ryanair non potesse essere considerato di proprietà di quest'ultima, in quanto lo stesso, essendo del tutto svincolato da specifiche tecniche e funzionali che ne dettano la scelta e l'organizzazione dei dati, non può essere considerato alla stregua di una manifestazione creativa e, quindi, proprietà intellettuale ai sensi dell'art. 2, 64-quinques e 64-sexies della Legge sul Copyright. La Corte ha quindi ritenuto che non vi fosse nemmeno protezione ai sensi della cosiddetta dottrina "sui generis" del database Rynair poiché la protezione di tale database era finalizzata ad escludere la commercializzazione dei biglietti aerei e non a proteggere gli sforzi di investimento di Ryanair. La condotta di Viagiare di "screen scraping" dei dati Ryanair relativi all'offerta di biglietti aerei è stata considerata legittima in quanto Ryanair - nei Termini di Utilizzo del suo sito web - ha fornito l'accesso (concessione di licenza) a terzi dei suoi dati
Osservatorio normativo
Authors: Nicotera Luisa , Masala Laura
Published: December 2018

L'osservatorio presenta i provvedimenti normativi nazionali maggiormente significativi del periodo di riferimento, riportando un breve commento a corredo dei testi pubblicati
Hubungan Komunikasi Keluarga dan Sekolah Remaja Puteri dengan Pengetahuan tentang Pre Menstruasi Sindrom (PMS) di SMPN 1 Tanjung Morawa
Authors: Wardani Fina Kusuma , Sari Indah Dewi
Published: December 2018

Pre menstruasi sindrom merupakan masalah yang cukup banyak dikeluhkan atau dialami wanita menjelang masa menstruasinya. Komunikasi keluarga dan sekolah memegang peranan penting dalam memberikan informasi yang benar kepada remaja puteri sehingga remaja puteri mengetahui mengenai pre menstruasi sindrom dan dapat mengurangi gejala pre menstruasi sindrom. Penelitian ini bertujuan untuk mengetahui hubungan komunikasi keluarga dan sekolah remaja puteri dengan pengetahuan tentang Pre Menstruasi Sindrom (PMS) di SMPN 1 Tanjung Morawa. Metode yang digunakan yaitu penelitian survei dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh siswi kelas VII yang telah mendapatkan menstruasi yaitu 132 siswi, dan diperoleh sampel berdasarkan kriteria inklusi dan eksklusi yaitu 108 siswi. Alat ukur menggunakan kuesioner, dan data diolah serta di analisis menggunakan uji chi square dan regresi logistik berganda. Hasil penelitian menunjukkan terdapat hubungan komunikasi keluarga (keterbukaan, empati, sikap positif, kesetaraan) dan komunikasi sekolah (keterbukaan dan kesetaraan) dengan pengetahuan remaja puteri tentang pre menstruasi sindrom. Variabel yang paling dominan adalah keterbukaan pada komunikasi sekolah (p=0,009) dan nilai Exp.B adalah 4,018. Disarankan bagi sekolah khususnya guru, teman dan pendidik sebaya dalam program PIK-R untuk lebih meningkatkan efektifitas komunikasi interpersonal dengan mempertimbangkan aspek keterbukaan, empati, sikap positif, sikap mendukung, dan kesetaraan/ kesamaan dalam melakukan komunikasi interpersonal ataupun pelaksaanaan bimbingan dan konseling bagi remaja puteri.
Hubungan Karakteristik Ibu Hamil dengan Status Anemia pada Trimester II dan III di Puskesmas Pantai Cermin Kabupaten Serdang Bedagai
Authors: Maulidanita Riska , Raja Sarma Lumban
Published: December 2018

Menurut  World Health Organization (WHO) memperkirakan 80% kematian ibu disebabkan oleh penyebab langsung dan 20% penyebab tidak langsung Berdasarkan hasil data dinas kesehatan kabupaten Serdang Bedagai (2007), ibu hamil yang mengalami anemia sebanyak 20%. Di wilayah Puskesmas Pariwisata Pantai Cermin Pada Tahun 2011 dan tahun 2012 tidak terdapat kasus kematian ibu. Desain penelitian ini adalah penelitian explanatory research (penelitian penjelasan) yaitu yang menghubungkan kausal antara variabel-variabel melalui pengujian hipotesa. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah teknik acidental sampling. Hasil penelitian ini diperoleh mayoritas pendidikan ibu SD (50,0%), mayoritas umur ibu 20-30 tahun (58,8%), mayoritas paritas ibu multigravida (17%), mayoritas jarak kehamilan ibu <1 tahun (38,3%), mayoritas pengetahuan ibu kurang (67,6%) dan mayoritas status anemia ibu terjadi anemia (64,7%).  Diharapkan kepada ibu hamil untuk meningkatkan pengetahuan tentang anemia melalui penyuluhan atau media dan mengaplikasikan pengetahuan tersebut di dalam  penyakit anemia.Kata Kunci : Karakteristik Ibu Hamil, Status Anemia Pada Trimester II dan III
Hubungan Pengetahuan, Sikap, Dan Dukungan Tenaga Kesehatan Dengan Keberhasilan ASI Eksklusif Di Wilayah Kerja Puskesmas Darussalam Kecamatan Medan Petisah
Authors: Juliani Sri , Arma Nuriah
Published: December 2018

Latar Belakang: World Health Organiation (WHO), pada tahun 2013 17% atau 98 juta balita di negara berkembang mengalami kekurangan gizi yang mengakibatkan kematian balita, dari kematian tersebut kurangnya pemberian gizi pada anak diantarnya adalah pemberian ASI Eksklusif yang tidak cukup. Tujuan: untuk mengetahui keberhasilan pencapain ASI Eksklusif di wilayah kerja Puskesmas Darussalam Kecamatan Medan Petisah tahun 2017. Metode: penelitian ini bersifat survei analitik dengan menggunakan desain cross sectional. Populasi penelitian ini sebanyak 170 responden, sampel dihitung dengan rumus slovin yaitu populasi dijadikan sampel sebanyak 120 responden yang diambil dengan teknik accidental sampling. Analisis data yang digunakan dalam penelitian ini adalah analisis univariat dan bivariat. Hasil: penelitian ini menggunakan uji Chi-Square memperlihatkan bahwa nilai signifikan probabilitas pengetahuan ibu adalah  p=0,005, sikap ibu adalah p=0,004 dan dukungan tenaga kesehatan ibu adalah p=0,007. Kesimpulan: penelitian ini menunjukkan ada hubungan pengetahuan, sikap, dan dukungan tenaga kesehatan dengan keberhasilan ASI Eksklusif. Diharapkan kepada tenaga kesehatan di Puskesmas Darussalam, perlu melakukan penyuluhan kesehatan tentang ASI Eksklusif kepada masyarakat untuk meningkatkan pengetahuan, pengalaman, dan perilaku kesehatan masyarakat agar masyarakat mengerti dan mau memberikan ASI Eksklusif kepada bayi mereka.
SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN DUTA MAHASISWA GENERASI BERENCANA BKKBN DENGAN METODE WEIGHTED PRODUCT (WP) (Studi Kasus Pada Kantor BKKBN Provinsi Gorontalo)
Authors: Mursalin Nurhayati , Ishak Rezqiwati
Published: December 2018

Pemilihan duta mahasiswa Generasi Berencana (GenRe) bertujuan tegar remaja yang berperilaku sehat, terhindar dari resiko tiga kesehatan reproduksi remaja, menunda usia pernikahan, dan memiliki perencanaan kehidupan berkeluarga untuk mewujudkan keluarga kecil bahagia dan sejahtera. Pemilihan Duta MahasiswaGenRe dimulai dari tahun 2010 hingga saat ini, dimana jumlah peserta setiap tahunnya ± 30 pasang dan hanya 1 pasang yang terpilih.Masalah yang muncul masaih ada unsur penilaian secara subyetif dan ada beberapa peserta yang memiliki nilai yang sama sehingga menyulitkan pihak pengambil keputusan untuk menentukan mana yang terbaik, untuk itu diperlukan sebuah sistem pendukung keputusan.Metodeyang digunakan adalah Weighted Product (WP).Berdasarkan hasil penelitian yang dilakukan, sistem ini dapat membantu pihak pengambil keputusan dalam menentukan alternatif terbaik menjadi duta mahasiswa GenRe untuk kategori Laki-Laki dengan nilai tertinggi 0,35119 dan kategori Perempuan dengan nilai tertinggi 0,35013 dan dengan adanya sistem iniproses pemilihannya menjadi lebih obyektif dan mudah.
NEWS OF WORLD PANCREATOLOGY (according to the materials of the International Association of Pancreatology, the Japan Pancreas Society, the Asian Oceanic Pancreatic Association, Sendai, Japan, August 2016)
Authors: Gubergrits N. B. , Byelyayeva N. V. , Zubov A. D. , Lukashevich G. M. , Fomenko P. G.
Published: December 2018

The article contains a short overview of the achievements of world pancreatology presented at the joint meeting of the International Association of Pancreatology, the Japan Pancreas Society, the Asian Oceanic Pancreatic Association (Japan, 2016). Particular attention is paid to the modern approaches of diagnostics and treatment of chronic pancreatitis and non-alcoholic fatty disease of the pancreas.
Malnutrition in patients with chronic pancreatitis
Authors: Gavrilina N. S. , Sedova G. A. , Kosyura S. D.
Published: December 2018

The lecture contains current data on prevalence of malnutrition among patients with chronic pancreatitis. We discuss the main pathogenetic mechanisms, clinical variants, diagnostic approaches and treatment methods of malnutrition.
Clinical course and approaches to the therapy of chronic pancreatitis in patients with comorbid pathology
Authors: Ruzhentsova Т. А.
Published: December 2018

The features of pathogenesis, clinical course and diagnostics of chronic pancreatitis combined with diseases of the cardiovascular system are discussed in the article. Results of the author’s own research on the effectiveness of influence of enzyme replacement therapy on the course of pancreatitis and comorbid pathology are presented. Significant positive dynamics of both manifestations of chronic pancreatitis and cardiovascular diseases, laboratory and instrumental examinations, improvement of patients’ quality of life upon the prescription of pancreatin are noted.
Gastroesophageal reflux disease and pregnancy
Authors: Plotnikova Y. Y. , Vologzhanina L. G. , Baranova Y. N.
Published: December 2018

This article describes the features of the course and diagnostics of gastroesophageal reflux disease in pregnant women, which is very common in this group of patients. Acceptable techniques of diagnostics of the disease are offered. Methods of non-pharmacological prevention and correction of heartburn are discussed as well. We also consider in detail the groups of drugs that are on the list of drugs allowed for pregnant women according to the FDA graduation. An analysis of drugs allowed for this group of patients that are present at the domestic market is provided.
Pancreatic encephalopathy: clinical, pathogenetic and diagnostic aspects
Authors: Damulin I. V. , Strutsenko А. А. , Ogurtsov P. P. , Mazurchik N. V.
Published: December 2018

Pancreatic encephalopathy occurs in 9–35% of patients with pancreatic diseases and is characterized by a variety of focal neurological symptoms. Neuropsychiatric disorders are observed both during the acute and latent period of the pancreatic diseases. The presence of pancreatic encephalopathy should be suspected if patients with symptoms of acute pancreatitis have neurological symptoms. The course of acute pancreatic encephalopathy is cyclical, fluctuating, being in direct proportion to the pancreatic process. Leading mechanism in the development of pancreatic encephalopathy is a combination of hyperenzymemia with insulin imbalance which leads to changes of water-electrolyte balance and carbohydrate metabolism. Infectious complications, that often accompany acute pancreatitis, lead to the increasing intoxication syndrome.
Clinical observation of family benign pancreatic hyperenzymemia
Authors: Gubskaya Y. Y. , Gubergrits N. B. , Klochkov A. Ye. , Alianova T. S. , Fomenko P. G.
Published: December 2018

The article provides a brief literature review on the problem of asymptomatic pancreatic hyperenzymemia and an algorithm for examining patients. The authors for the first time in Ukraine have described the clinical observation of family with Gullo’s syndrome — family benign pancreatic hyperenzymemia. Family members were carefully examined, structural changes in the pancreas were excluded, and its normal functional state was proved. The results of a genetic examination are presented.
Intelligent medical systems in diagnosing and treating inflammatory diseases of the pancreas (systematic review)
Authors: Litvin A. A.
Published: December 2018

This paper is a systematic review of the literature on the use of intelligent medical systems in the diagnosis and treatment of acute inflammatory pancreatic diseases. The author provides modern literature data on the efficacy of decision support systems based on artificial neural networks to determine the severity, diagnosis and outcome prognosis of pancreatitis and complications.
About the influence of the way of restoration of the gastrointestinal continuity on function of the pancreas
Authors: Koshel A. P. , Kurtseitov N. E. , Rakina Y. Y.
Published: December 2018

The analysis of results of surgical treatment of 62 patients with postgastrectomy syndrome: 41 (66.1%) men and 21 (33.9%) women aged from 35 to 69 years (middle age 48.2±13.1 years) has been presented. The signs of chronic pancreatitis have been revealed in 24 (38.7%) patients. Relapsing form was observed in 19 (79.2%) patients, painful – in 5 (20.8%) cases. Performance of the reconstructive operations, providing restoration of natural passage of food through duodenal gut, promoted restoration of indicators of the content of carbohydrates in blood, eliminating the basis of a variety of postgastrectomy damages, including chronic pancreatitis in 6 (25%) patients.
Clinical observation of IgG4-associated disease
Authors: Gubergrits N. B. , Dyadyk Y. А. , Klochkov A. Ye. , Byelyayeva N. V. , Ivanova M. D. , Ginkota Y. А. , Chirkov Y. E.
Published: December 2018

The article presents general ideas on IgG4-associated disease, two types of autoimmune pancreatitis, major and additional histopathological criteria, a diagnostic scheme for IgG4-associated disease using histological criteria. The authors described a clinical case of disease involving the pancreas and biliary tract. Lessons of clinical observation are drawn.
Stem mesenchymal bone marrow cells in the treatment of ulcerative colitis based on morphological and immunological research (literature review)
Authors: Rakhmetova V. S. , Orazbayeva A. B. , Amrenova A. Y.
Published: December 2018

The use of stem cells in complex therapy of inflammatory bowel diseases has became perspective therapeutic strategy. Mesenchymal stem cells, which have immunomodulatory, anti-inflammatory properties and high regenerative potential, are used for therapy of inflammatory bowel disease, what is making them attractive to clinical application. According to the results of the conducted studies, mesenchymal stem cells improve clinical and microscopic manifestations of colitis, reduce system and local production of pro-inflammatory cytokines, suppress inflammatory process, stimulating tissue regeneration at the same time, promote the increase in the duration of remission of a disease, reduce the risk of the relapse of ulcerative colitis. Preliminary results of clinical and experimental studies carried out in the world justify the relevance, prospects and sufficient safety of the transplantation method of allogenic mesenchymal stromal cells of bone marrow for treatment of patients with the ulcerative colitis.
Physiology and pathology of the liver in pregnant women
Authors: Linevskiy Y. V. , Linevskaya K. Y. , Voronin K. A.
Published: December 2018

The deviations of the liver in normal pregnancy are described, as well as clinical picture, diagnostics and treatment of liver disease associated with pregnancy, which appeared on the background of pregnancy and preceding chronic liver disease.
Evidence-based pancreatology 2017/2018 (review of the results of studies on chronic pancreatitis and exocrine pancreatic insufficiency
Authors: Gubergrits N. B. , Byelyayeva N. V. , Lukashevish G. M. , Berezhnaya E. V.
Published: December 2018

The article provides an overview of the European recommendations on the diagnosis and treatment of chronic pancreatitis. The results of evidence-based research related to the epidemiology, course of chronic pancreatitis, assessment of the informative value of various imaging techniques, reatment of pancreatic insufficiency upon chronic pancreatitis, cystic fibrosis, pancreatic cancer are analyzed. A conclusion is drawn about the need for further carrying out of evidence-based studies.
Gastroesophageal reflux disease: current state of the problem and prospects
Authors: Tsimmerman Y. S. , Vologzhanina L. G.
Published: December 2018

The article is a lecture for doctors which includes modern ideas about gastroesophageal reflux disease: its etiology and pathogenesis, risk factors, clinical features and diagnostics. The classification, strategy and tactics of treatment are explained in detail. The author critically evaluated the literature data and expressed his reasoned critical point of view concerning the basic concepts, diagnostics and treatment of the disease.
Learning uncomfortably
Authors: Sadowska Noemi , Laffy Dominic
Published: December 2018

This paper outlines a research process entwined with delivery of a final year elective module “Managing Strategic Design”. This module challenges a mixture of business and design management final year undergraduate students to devel-op truly innovative business opportunities. The research has been based on six roundtable discussions with a variety of participants from design and business communities, as well as classroom observation and reflections from students on the aforementioned elective module. The process of creating these innovative opportunities is at times deeply uncomfortable but it is at these points that stu-dents’ learning can be most productive. The iterative process of research and teaching have led us, the authors, to reflect on the value and positioning of de-sign and strategic thinking in business education: the methodology behind our particular curriculum delivery drawing on cross disciplinary teaching and learn-ing; and the ability of students to learn from practice by experiencing ‘zones of discomfort’ and ‘what if’ scenarios. These reflections have altered the focus of the elective module, from provision of tools students need to know to under-standing the learning journey and facilitating the acquisition of decision-making confidence in response to a complex challenge.
Experiences of Turkish Cypriot, Kurdish and Turkish Youth in Creating Transnational Social Spaces in London Schools
Authors: Simsek Dogus
Published: December 2018

This paper focuses on the role of school in identity formation of Turkish Cypriot, Kurdish and Turkish youths (thereafter TCKT) living in London and explores the perceptions of young people about their school life, mainly focusing on secondary school experiences, and exploring the difficulties faced in their relations with peers. It also examines the forms of homogeneity and heterogeneity within the school environment, examining their influence on identity formation and the negotiation of transnational social spaces by TCKT youth. The homogeneity of schools in London prevents them from forming identities based on interaction with various cultures and, therefore, limits their ability to create transnational social spaces.
Achieving Collaborative Aims through Multiple Identity Construction: Managing a public inter-organizational collaboration
Authors: Kourti Isidora
Published: December 2018

Although public inter-organizational collaborations can offer better public services, their management is a complex endeavour and they often fail. This paper explores identity construction as a key aspect that assists in managing successfully these collaborations. The study draws upon a longitudinal ethnographic study with a Greek public inter-organizational collaboration. The research illustrates that managers should encourage partners to construct collaborative and non-collaborative identities in order to achieve the collaboration aims. It also suggests that managers should seek both stability and change in the collaborative process and offers four collaborative patterns for the effective management of public inter-organizational collaborations.
Alt kültür gruplarında suç ve toplumsallaşma ilişkisi: Karaman Çingeneleri örneği
Authors: Güllü İsmail , Yıldırım Kerim
Published: December 2018

English Title:Crime and socialisation dynamics in sub-cultures: Case of Gypsies in KaramanAbstractIn this study, the relationship between crime and the socialization process in Gypsy subculture is examined. This is is a qualitative study analysing the relationship between crime and the socialization process among Gypsies in different parts of Karaman between the years 2014-2015, especially the “Yeni” neighborhood known as Abdali district. In-depth interviews helped us to group Gypsy families into four different family types. It can be said that during unique socialization process of Gypsy subculture, Gypsy individuals’ attitudes to crime is shaped in the context of its unique dynamics through their families, relatives and friends. Unlike other social groups, the Gypsy subculture allows forming a habitus conducive to be involved in crime. Although they have common social characteristics with Gypsies living in different parts of Turkey, Gypsies in Karaman have a distinctive lifestyle and habitus due to their unique socialization process.Keywords: Gypsy; crime; culture; religion; socialization ÖzetBu çalışmada Çingene alt kültürü içerisindeki toplumsallaşma sürecinin suç ile ilişkisi incelenmektedir. Nitel bir çalışma olarak tasarlanan bu çalışma 2014-2015 yılları arasında Karaman’ın Abdal Mahallesi olarak bilinen Yeni Mahalle başta olmak üzere farklı bölgelerinde yaşayan Çingenelerin toplumsallaşma süreçleri içerisinde suç ile ilişkilerini sosyolojik olarak analiz etmeyi amaçlamaktadır. Bu çalışmada Çingene aileleri karakteristik özelliklerine göre dört farklı aile tipi şeklinde sınıflandırılmıştır. Araştırmada Çingene alt kültürünün kendine özgü toplumsallaşma süreçleri içinde Çingene bireylerin suç ile ilişkilerinin onların aile, akraba ve arkadaş çevresi ile ilişkileri bağlamında kendine özgü dinamikleri içinde şekillendiği görülmektedir. Diğer toplumsal kesimlerden farklı olarak Çingene alt kültürü kendi içinde suçun üretilmesini sağlayan bir habitusun oluşmasına imkan vermektedir. Karaman’daki Çingeneler, Türkiye’nin farklı bölgelerinde yaşayan Çingeneler ile ortak toplumsal özellikler göstermekle birlikte burada geçirilen toplumsallaşma süreçleri içinde kendine özgü bir yaşam tarzı ve habitus üretmektedir.
Entering the public sphere: the citizenship practices of US immigrants
Authors: Brettell Caroline B.
Published: December 2018

This paper originally delivered as a keynote speech at the Turkish Migration Conference 2015 in Prague, Czech Republic on June 25, 2015. It focuses on civic engagementi political participation and citizenship practices of Asian Indians in Dallas Fort Worth Metropolitan area drawing on qualitative field research material. Community participation is a process. Embedded in this observation is an understanding that as the individual branches out, he or she is becoming involved with associations with great civic and/or political presence, moving from one community of practice to another, and from a peripheral position to one of greater participation to invoke the ideas of Lave and Wenger. But equally, these activities illustrate how new immigrants construct their own sense of belonging as they engage with and interpret what it means to be an American and what kind of an American they want to be.
Shaping the Verisimilitude: Moral Didacticism and Neoclassical Principles Responsible for the Rise of the English Novel?
Authors: Golban Petru
Published: December 2018

The rise of the novel is a major aspect of the eighteenth century British literature having a remarkable typology: picaresque, adventure, epistolary, sentimental, of manners, moral, comic, anti-novel. The comic (including satirical) attitude, social concern, moral didacticism, and other thematically textualized aspects – emerging from both picaresque tradition and neoclassical principles – and together with picaresque tradition and neoclassical principles – are responsible for the emergence of verisimilitude as the forming element responsible in turn for the rise of the literary system of the novel.
“Look, You Machame You Dog”: The Story of an Anti-Islamic Inscription on St. Stephen’s Cathedral in Vienna
Authors: Fürlinger Ernst
Published: December 2018

After the 1683 Siege of Vienna, an anti-Islamic inscription and sculpture – possibly representing the head of Muhammad – were affixed onto the tower of St. Stephen’s cathedral in Vienna. In the 21st century, this story highlights the difficulties that arise when the collective memory of the former Catholic empire or nation collides with human rights norms of the modern constitutional republic as well with the norms of religious dialogue in the Catholic Church.
Economic Analysis of the Refugee Influx to Austria
Authors: Berger Johannes , Strohner Ludwig
Published: December 2018

This paper presents an economic assessment of the current refugee influx to Austria. Conclusions that can be drawn from Swedish experience suggest below average labour force integration of refugees, particularly in the first years after arrival. The skill composition of refugees is taken from surveys. The simulation model PuMA suggests a considerable employment increase, particularly of the unskilled workforce. This rise in employment remains, however, significantly below the number of additional refugees. The unemployment rate rises and is concentrated upon the refugees, but to a smaller extent unskilled residents are affected as well. Furthermore, wage developments of unskilled residents are below average. GDP per capita is negatively affected as a result of below average productivity and employment opportunities of refugees.