bluuebunny/crossref_metadata_2025 huggingface dataset:
Service social : une longue tradition d’intervention lors d’une crise suicidaire
Authors: Tremblay Gilles
Published: April 2013

Ce texte porte sur la place du service social dans la recherche et l’intervention en matière de suicide. Il se divise en trois sections : le paradoxe du service social par rapport au suicide, les apports de cette profession dans l’intervention et la recherche, et un exemple à partir d’une recherche menée par l’auteur sur la dépression chez les hommes.
Portrait du recours aux services de santé mentale avant et après une tentative de suicide qui requiert une hospitalisation
Authors: Routhier Danielle , Leduc Nicole , Lesage Alain , Benigeri Mike
Published: April 2013

Les services de santé ont un rôle important à jouer en matière de prévention du suicide. À partir de données médico-administratives, nous avons analysé les patrons de recours aux services de santé mentale avant et après une hospitalisation pour tentative de suicide, chez les Montréalais qui ont reçu un diagnostic de schizophrénie ou de dépression. Les résultats laissent poindre des avancés en matière de prévention, notamment chez les hommes avec un trouble concomitant d’abus de substances, reconnus comme particulièrement vulnérables. Par contre, d’autres constats inquiètent. L’urgence comme porte d’entrée aux services de santé mentale ne semble pas garante du recours aux services suivant une hospitalisation pour tentative de suicide. Des interventions sont requises en vue de faciliter l’accès et d’améliorer la coordination entre les différents services de santé.
Ce que la microscopie peut nous apprendre sur le suicide
Authors: Mechawar Naguib
Published: April 2013

La neuroanatomie fine des troubles de l’humeur et du suicide est une discipline relativement récente. En complément à la neuroimagerie, à la biologie moléculaire et à la biochimie, les analyses histologiques post-mortem des circuiteries cérébrales impliquées dans la régulation de l’humeur permettent de mieux comprendre les mécanismes cellulaires et moléculaires qui sous-tendent la dépression majeure et le suicide. Dans cet article, je discute de travaux récents réalisés au sein de mon laboratoire sur la neuroanatomie fine du cortex cingulaire antérieur (CCA). Plus particulièrement, je présente des résultants qui indiquent que les astrocytes fibreux de la matière blanche du CCA sont hypertrophiés chez des dépressifs qui se sont suicidés. Ces données sont interprétées dans le contexte de l’hypothèse neuro-immunitaire de la dépression et du suicide.
O uso das tecnologias digitais entre os seniores: motivações e interesses
Authors: Dias Isabel
Published: April 2013

O artigo tem como principal objetivo analisar a relação dos seniores mais jovens (55-65 anos) e dos mais velhos (66 ou mais anos) com as tecnologias da informação e da comunicação (TIC), em particular com o computador e a internet. Desenvolve-se uma análise de cariz quantitativo, com base num inquérito por questionário administrado nas cidades de Lisboa, Porto e Coimbra a uma amostra de 792 indivíduos, em complementaridade com alguns dados qualitativos recolhidos através de 30 entrevistas semiestruturadas. Tenta-se conhecer as motivações e interesses ligados ao uso das referidas tecnologias e compreender em que medida tal prática contribui para a inclusão dos mais velhos nas sociedades tecnológicas e incrementa as relações e solidariedades intergeracionais e amicais.
Género e política: análise sobre as resistências nos discursos e nas práticas sociais face à Lei da Paridade
Authors: Santos Maria Helena , Amâncio Lígia
Published: April 2013

O reconhecimento da desigualdade de género na política tem conduzido à adoção de medidas de ação positiva a nível mundial, como é disso exemplo a Lei da Paridade aprovada em Portugal em 2006. Tal como noutros países, onde estas medidas foram adotadas, também em Portugal elas suscitaram controvérsia social, um terreno particularmente rico de análise para as práticas assentes na ideologia de género. Centrando-se no ciclo eleitoral de 2009, este estudo pretendeu verificar se a Lei da Paridade foi cumprida pelos grandes partidos políticos portugueses e, além disso, conhecer os discursos que emergiram sobre o tema na imprensa periódica. Os resultados revelaram o cumprimento da lei e os seus efeitos positivos na representação das mulheres nestes partidos políticos nas eleições europeias e, embora menos, nas legislativas, e o seu incumprimento nas autárquicas, para além de mostrarem que as resistências à lei permanecem sustentadas por uma ideologia que define a política como um território masculino.
Regulação de procedimentos na escola pública: entre o centralismo formal e a apropriação informal
Authors: Veloso Luísa , Rufino Isabel , Craveiro Daniela
Published: April 2013

A presente análise propõe uma reflexão sobre a forma como os processos de coordenação do trabalho nas organizações escolares, ao nível da conceção e planeamento educativo, são enunciados nos relatórios de avaliação externa das escolas e pelas respetivas direções. Tem como base informação contemplada nos relatórios da avaliação externa das escolas de três regiões distintas em Portugal — Lisboa e Vale do Tejo, Alentejo e Algarve — e entrevistas realizadas aos dirigentes de 20 escolas. Esta abordagem permite conhecer modos de formalização dos instrumentos estruturantes e destacar a importância dos processos e mecanismos de apropriação informal (ajustamento mútuo) que têm lugar, tanto ao nível da construção como da operacionalização dos processos de regulação formais na gestão das escolas portuguesas (estandardização).
Cuidado: um desafio para as organizações saudáveis? Estudo de caso de um serviço hospitalar
Authors: Billquist Leila , Szücs Stefan , Bäck-Wiklund Margareta
Published: April 2013

Neste artigo estudamos uma organização saudável através da exploração da agenda dual, na perspetiva de uma organização de serviços a pessoas. Olhando para o caso de um departamento especializado num hospital universitário na Suécia, analisamos se o conceito de organização saudável necessita de uma dimensão adicional. Foram usados métodos quantitativos e qualitativos, recolhidos no âmbito do projeto europeu Qualidade de Vida numa Europa em Mudança. Explorámos a agenda dual em dois planos — a dualidade do trabalho doméstico e a dualidade do trabalho em contexto organizacional. Usámos uma abordagem multi-método que dá a conhecer uma realidade complexa, especialmente no que diz respeito ao stress e à intensidade da carga de trabalho.
Safety and peaceful coexistence policies in Latin American schools: human rights perspective
Authors: Rodino Ana María
Published: April 2013

The paper presents the theoretical framework, methodology and results of the X Inter-American Report on Human Rights Education, produced in 2011 by the Inter-American Institute for Human Rights (Costa Rica) under the coordination of the author. The research examines the increasing problem of securing peaceful coexistence,safety and prevention of school violence in 17 Latin American countries from South, Central and North America, and the educational policies they have developed or are currently developing to face it, analyzed from a human rights perspective.
The prevalence of violence towards the elderly: a critical review of the literature
Authors: Santos Ana João , Nicolau Rita , Fernandes Ana Alexandre , Gil Ana Paula
Published: April 2013

The studies on the prevalence of violence towards the elderly in a family context that have been conducted in the last thirty years, especially in Europe and Anglo-Saxon countries, are not sufficiently elucidative. This is due to shortcomings in both the definition of their theoretical models and their operative  concepts. The authors of this article have systematically reviewed the literature and identified a diversity of definitions and research designs, which has an inevitable impact in terms of varying estimates. The European public perception of this problem is also at odds with the low figures contained in this type of estimate. The authors offer somethoughts about the underlying reasons for these representations, and critique the estimates made in population-based prevalence studies.
Energy and environment public policies: towards a sustainable country?
Authors: Araújo Luísa , Coelho Maria João
Published: April 2013

In recent decades, energy and environment public policies have acquired an unquestioned strategic and economic importance. In this article,wedrawthe path of these policies in Portugal over the last 40 years, anchoring the analysis in the international context, particularly in the context of the European Union. The main results of the public policies are displayed and a brief analysis of the strategy to be undertaken by Portugal within its context of economic and financial crisis is presented.
Origin of Species
Authors: Sorkin Michael
Published: April 2013

The renowned architect, academic and thinker Michael Sorkin reflects on the geneses of architecture, where it comes from and its current status, concluding that ‘the idea of an architecture that participates in a collective stewardship and equitable sharing of the earth ‐ and wears it on its sleeve ‐ works for me’. He illustrates his article with some of his studio's work from the last two decades that has been inspired by nature in its iconography, embracing an entire menagerie of forms.
Quit the Grey Limbo and Return to Paradise
Authors: Cannon Matthew , Gianvanni Mascia
Published: April 2013

In three projects, Matthew Cannon and Mascia Gianvanni of FutureScape Studio explore the possibilities of alleviating the mundaneness of urban life through the introduction of the absurdity of nature, which brings ‘joy and laughter to the stressed worker’. Devices range from a sardine on the London Underground and a giraffe in the office to injecting a sublime, painterly light into the city.
Landscape Utopianism: Information, Ecology and Generative Pastoralism
Authors: Marinic Gregory
Published: April 2013

Architect and educator Gregory Marinic describes how the 21st century is witnessing the rise of a new utopianism through landscape/architectural interventions that pursue the possibilities of ‘ersatz utopias within our quotidian world’. He illustrates this with his own collaborative works and competition entries for d3, an art‐architecture stewardship programme based in New York of which he is director.
Open Fields: The New Rural Design Revolution
Authors: Parvin Alastair
Published: April 2013

Alastair Parvin, an architectural and strategic designer at 00:/, calls for a focus on ‘the opposite side of the urbanisation story: the impact that urbanisation has on rural areas’. He advocates a rural design revolution that re‐engages with farming and the countryside as a site of intense production, rather than as a preserve for nostalgia and leisure activities.
Et in Arcadia ego, Et in Arcadia est
Authors: Rhowbotham Kevin
Published: April 2013

Architect, academic and broadcaster Kevin Rhowbotham scrutinises the reasoning and value of the New Pastoralism project. He dispels the Arcadian impulse as ‘a specious and mythicised image of the rural’, calling upon architects to seek a true understanding of rural conditions in relation to the urban.
A Multiwalled‐Carbon‐Nanotube‐Based Biosensor for Monitoring Microcystin‐LR in Sources of Drinking Water Supplies
Authors: Han Changseok , Doepke Amos , Cho Wondong , Likodimos Vlassis , de la Cruz Armah A. , Back Tyson , Heineman William R. , Halsall H. Brian , Shanov Vesselin N. , Schulz Mark J. , Falaras Polycarpos , Dionysiou Dionysios D.
Published: April 2013

A multiwalled carbon nanotube (MWCNT)‐based electrochemical biosensor is developed for monitoring microcystin‐LR (MC‐LR), a toxic cyanobacterial toxin, in sources of drinking water supplies. The biosensor electrodes are fabricated using vertically well‐aligned, dense, millimeter‐long MWCNT arrays with a narrow size distribution, grown on patterned Si substrates by water‐assisted chemical vapor deposition. High temperature thermal treatment (2500 °C) in an Ar atmosphere is used to enhance the crystallinity of the pristine materials, followed by electrochemical functionalization in alkaline solution to produce oxygen‐containing functional groups on the MWCNT surface, thus providing the anchoring sites for linking molecules that allow the immobilization of MC‐LR onto the MWCNT array electrodes. Addition of the monoclonal antibodies specific to MC‐LR in the incubation solutions offers the required sensor specificity for toxin detection. The performance of the MWCNT array biosensor is evaluated using micro‐Raman spectroscopy, including polarized Raman measurements, X‐ray photoelectron spectroscopy, cyclic voltammetry, optical microscopy, and Faradaic electrochemical impedance spectroscopy. A linear dependence of the electron‐transfer resistance on the MC‐LR concentration is observed in the range of 0.05 to 20 μg L−1, which enables cyanotoxin monitoring well below the World Health Organization (WHO) provisional concentration limit of 1 μg L−1 for MC‐LR in drinking water.
Nano‐Sized CT Contrast Agents
Authors: Lee Nohyun , Choi Seung Hong , Hyeon Taeghwan
Published: April 2013

Computed tomography (CT) is one of the most widely used clinical imaging modalities. In order to increase the sensitivity of CT, small iodinated compounds are used as injectable contrast agents. However, the iodinated contrast agents are excreted through the kidney and have short circulation times. This rapid renal clearance not only restricts in vivo applications that require long circulation times but also sometimes induces serious adverse effects related to the excretion pathway. In addition, the X‐ray attenuation of iodine is not efficient for clinical CT that uses high‐energy X‐ray. Due to these limitations, nano‐sized iodinated CT contrast agents have been developed that can increase the circulation time and decrease the adverse effects. In addition to iodine, nanoparticles based on heavy atoms such as gold, lanthanides, and tantalum are used as more efficient CT contrast agents. In this review, we summarize the recent progresses made in nano‐sized CT contrast agents.
Total body computed tomography scan in the initial work‐up of Binet stage A chronic lymphocytic leukemia patients: Results of the prospective, multicenter O‐CLL1‐GISL study
Authors: Gentile Massimo , Cutrona Giovanna , Fabris Sonia , Pesce Emanuela Anna , Baldini Luca , Di Raimondo Francesco , Musolino Caterina , Di Tonno Paolo , Di Renzo Nicola , Molica Stefano , Brugiatelli Maura , Ilariucci Fiorella , Zupo Simona , Matis Serena , Maura Francesco , Vigna Ernesto , Angrilli Francesco , Recchia Anna Grazia , Quarta Giovanni , Iannitto Emilio , Fragasso Alberto , Musto Pellegrino , Spriano Mauro , Vincelli Iolanda , Vallisa Daniele , Cortelezzi Agostino , Mauro Francesca Romana , Foà Robin , Federico Massimo , Neri Antonino , Ferrarini Manlio , Morabito Fortunato
Published: April 2013

Total body computed tomography (TB‐CT) scan is not mandatory in the diagnostic/staging algorithm of chronic lymphocytic leukemia (CLL). The aim of this study was to determine the value and prognostic significance of TB‐CT scan in early stage CLL patients. Baseline TB‐CT scan was performed in 240 Binet stage A CLL patients (179 Rai low‐ and 61 Rai intermediate‐risk) included in a prospective multicenter observational study (clinicaltrial.gov ID:NCT00917549). The cohort included 69 clinical monoclonal B lymphocytosis (cMBLs). Patients were restaged considering only radiological data. Following TB‐CT scans, 20% of cases reclassified as radiologic Binet (r‐Binet) stage B. r‐Binet B patients showed a higher incidence of unfavorable cytogenetic abnormalities (P = 0.027), as well as a shorter PFS (P = 0.001). At multivariate analysis, r‐Binet stage [HR = 2.48; P = 0.004] and IGHV mutational status [HR = 3.01; P = 0.002] retained an independent predictive value for PFS. Among 179 Rai low‐risk cases, 100 were redefined as r‐Rai intermediate‐risk based upon TB‐CT scan data, showing a higher rate of cases with higher ZAP‐70 (P = 0.033) and CD38 expression (P = 0.029) and β2‐microglobulin levels (P < 0.0001), as well as a shorter PFS than those with r‐Rai low‐risk (P = 0.008). r‐Rai stage [HR = 2.78; P = 0.046] and IGHV mutational status [HR = 4.25; P = 0.009] retained a significant predictive value for PFS at multivariate analysis. Forty‐two percent of cMBL patients were reclassified as r‐small lymphocytic lymphomas (r‐SLLs) by TB‐CT scan. TB‐CT scan appears to provide relevant information in early stage CLL related to the potential and the timing of patients to progress towards the more advanced disease stages. Am. J. Hematol. 88:539–544, 2013. © 2013 Wiley Periodicals, Inc.
Characterization of human cortical gene expression in relation to glucose utilization
Authors: Sterner Kirstin N. , Mcgowen Michael R. , Chugani Harry T. , Tarca Adi L. , Sherwood Chet C. , Hof Patrick R. , Kuzawa Christopher W. , Boddy Amy M. , Raaum Ryan L. , Weckle Amy , Lipovich Leonard , Grossman Lawrence I. , Uddin Monica , Goodman Morris , Wildman Derek E.
Published: April 2013

Objectives

Human brain development follows a unique pattern characterized by a prolonged period of postnatal growth and reorganization, and a postnatal peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. The objectives of this study were to determine developmental trajectories of gene expression and to examine the evolutionary history of genes differentially expressed as a function of age.

Methods

We used microarrays to determine age‐related patterns of mRNA expression in human cerebral cortical samples ranging from infancy to adulthood. In contrast to previous developmental gene expression studies of human neocortex that relied on postmortem tissue, we measured mRNA expression from the nondiseased margins of surgically resected tissue. We used regression models designed to identify transcripts that followed significant linear or curvilinear functions of age and used population genetics techniques to examine the evolution of these genes.

Results

We identified 40 transcripts with significant age‐related trajectories in expression. Ten genes have documented roles in nervous system development and energy metabolism, others are novel candidates in brain development. Sixteen transcripts showed similar patterns of expression, characterized by decreasing expression during childhood. Comparative genomic analyses revealed that the regulatory regions of three genes have evidence of adaptive evolution in recent human evolution.

Conclusions

These findings provide evidence that a subset of genes expressed in the human cerebral cortex broadly mirror developmental patterns of cortical glucose consumption. Whether there is a causal relationship between gene expression and glucose utilization remains to be determined. Am. J. Hum. Biol. 25:418–430, 2013. © 2013 Wiley Periodicals, Inc.
Methodik zur Unsicherheitsbewertung und Sensitivitätsanalyse für thermische Gebäudesimulationen
Authors: Burhenne Sebastian , Herkel Sebastian
Published: April 2013

Unsichere Randbedingungen haben einen großen Einfluss auf das Ergebnis von Gebäudesimulationen. Trotzdem werden Unsicherheitsbewertungen und Sensitivitätsanalysen bisher in der Planungspraxis und auch in wissenschaftlichen Untersuchungen selten durchgeführt. In diesem Beitrag wird eine Methodik zur Unsicherheitsbewertung und Sensitivitätsanalyse für thermische Gebäudesimulationen vorgestellt. Diese wird exemplarisch angewendet, um Einsatzmöglichkeiten darzustellen. Potentielle Einsatzgebiete sind Simulationen im Planungsprozess von Gebäuden sowie eine simulationsbasierte Gebäudebetriebsanalyse. Die Anwendung der Methodik kann dazu beitragen, den Planungsprozess und den Gebäudebetrieb zu verbessern.

Methodology for uncertainty and sensitivity analysis for building performance simulation. Uncertainties in simulation input have a big influence on building performance simulation results. Nevertheless, uncertainty quantification and sensitivity analysis is not commonly applied in the design practice and also in scientific research. In this paper a methodology for uncertainty quantification and sensitivity analysis is introduced. The methodology is applied to an example case to illustrate possible applications. It can be used within the design stage of buildings as well as for simulation ‐based building operation analysis. The methodology can improve the design process as well as building operation.
Conveying Characteristics of Pulverized Coal in a Top‐Discharge Blow Tank System
Authors: Xu G.‐L. , Chen X.‐P. , Liang C. , Liu D.‐Y. , Xu P. , Cai J.‐Y. , Zhao C.‐S.
Published: April 2013

Based on the experiments of pulverized coal pneumatic conveying using nitrogen as carrier, the influences of riser inlet height above the gas distribution plate, riser diameter, pulverized coal external moisture content, and supplemental gas flow rate on the conveying characteristics such as pulverized coal mass flow rate and solid‐gas ratio were investigated in a laboratory‐scale experimental setup of a top‐discharge blow tank under atmospheric pressure. There exists an optimal riser inlet height for a given top‐discharge blow tank. The supplemental gas is one of the critical factors affecting the conveying stability and continuity. A model for material mass flow rate prediction with errors ranging from –25 % to +15 % is presented.
Development of a Scalable Method for Manufacturing High‐Temperature CO2 Capture Sorbents
Authors: Yu C. T. , Chen W. C.
Published: April 2013

An engineered process for scalable manufacture of a calcium aluminum carbonate CO2 sorbent with production amounts of about 1000 g per hour has been developed. The process includes mixing and heating, solid‐liquid separation, drying and extrusion, crushing and conveying, and calcined molding steps. The sorbent preparation involves the coprecipitation of Ca2+, Al3+, and CO32– under alkaline conditions. By adjusting the Ca:Al molar ratio, a series of Ca‐rich materials could be synthesized for use as CO2 sorbents at 750 °C. A calcium acetate‐derived sorbent exhibited better cyclic stability than sorbents originating from CaCl2 and Ca(NO3)2. The initial sorption capacity increased with CaO concentration. High stability of more than 90 % was maintained by the Ca:Al sorbents after 40 looping tests.
Amide‐Controlled Highly Selective Catalytic Borylcupration of Allenes
Authors: Yuan Weiming , Zhang Xue , Yu Yihua , Ma Shengming
Published: April 2013

A novel copper‐catalyzed, highly regio‐ and stereoselective borylcupration of substituted 2,3‐allenamides with bis(pinacolato)diboron producing Z‐β‐borylated β,γ‐unsaturated enoamides has been demonstrated. Due to the unique effect of the amide‐group, perfect regio‐ and stereoselectivity and good to excellent yields have been achieved, which were rationalized by a DFT study.
ChemInform Abstract: The New Alkali Cyclotrisilicate Cs8[Si6O16].
Authors: Hlukhyy Viktor , Faessler Thomas F.
Published: April 2013

Hygroscopic transparent single crystals of Cs8[Si6O16] are obtained by high‐temperature reaction of Cs, Si, WO3, and HgO in the molar ratio of 5:5:1:1 (sealed Nb crucible in a fused silica tube, 1.
ChemInform Abstract: Sulfide Iodides (MSI) of the Heavier Lanthanoids (M: Gd—Lu): Crystal Structures and Magnetic Properties.
Authors: Blaschkowski Bjoern , Rosner Helge , Schnelle Walter , Schleid Thomas
Published: April 2013

Lanthanoide sulfide iodides LnSI with Ln: Gd—Lu are prepared by solid state reaction of an equimolar mixture of Ln, S and I (fused silica tube, 900 °C, 10 d) and powder XRD cell parameters are given.
ChemInform Abstract: Ternary Aluminides Ln0.67Ni2Al6 (Ln: Sc, Y, Gd—Lu) with Partly Disordered Structures.
Authors: Matselko Oksana , Pukas Svitlana , Lutsyshyn Yuriy , Gladyshevskii Roman , Kaczorowski Dariusz
Published: April 2013

The title compounds are prepared by arc‐melting of the elements followed by annealing under vacuum at 600 °C for one month.
ChemInform Abstract: High Pressure Synthesis and Crystal Structure of a Ternary Superconductor Ca2Al3Si4 Containing Layer Structured Calcium Sub‐Network Isomorphous with Black Phosphorus.
Authors: Tanaka Masashi , Zhang Shuai , Tanaka Yuki , Inumaru Kei , Yamanaka Shoji
Published: April 2013

The title compound is prepared by reaction of a stoichiometric mixture of CaSi2, Al, and Si at 1000 °C under a pressure of 5 GPa (1 h).
ChemInform Abstract: Tandem Sequence of Phenol Oxidation and Intramolecular Addition as a Method in Building Heterocycles.
Authors: Ratnikov Maxim O. , Farkas Linda E. , Doyle Michael P.
Published: April 2013

Rhodium‐catalyzed oxidation of p‐substituted phenols with tBuOOH followed by intramolecular Michael‐addition opens access to a variety of oxa‐ and aza‐heterocycles.
ChemInform Abstract: Phosphonium Chloride as a Non‐Volatile Chlorinating Reagent: Preparation and Reaction in No Solvent or Ionic Liquid.
Authors: Sugimoto Osamu , Harada Yukihiro , Tanji Ken‐ichi
Published: April 2013

Phosphonium chloride PPC prepared in situ from trichloroisocyanuric acid and triphenylphosphine is used for the conversion of hydroxyheterocycles to chloroheterocycles, of carboxylic acids to esters or amides and of amides to nitriles.
ChemInform Abstract: Chemoselective Nitration of Aromatic Sulfonamides with tert‐Butyl Nitrite.
Authors: Kilpatrick Brenden , Heller Markus , Arns Steve
Published: April 2013

A novel method for selective nitration of sulfonamides using tert‐butyl nitrite as the nitrating reagent is developed.
ChemInform Abstract: Rhodium‐Catalyzed Regioselective Amidation of Indoles with Sulfonyl Azides via C—H Bond Activation.
Authors: Shi Jingjing , Zhou Bing , Yang Yaxi , Li Yuanchao
Published: April 2013

This reaction tolerates a variety of functional groups, water, and air.
ChemInform Abstract: Efficient Synthesis of Cyanohydrin Trimethylsilyl Ethers via 1,2‐Chemoselective Cyanosilylation of Carbonyls.
Authors: Strappaveccia Giacomo , Lanari Daniela , Gelman Dmitri , Pizzo Ferdinando , Rosati Ornelio , Curini Massimo , Vaccaro Luigi
Published: April 2013

The cyanosilylation of carbonyl compounds (I) and (IV) using TmsCN (II) and triphenylphosphine supported on polystyrene as catalyst under solvent‐free conditions is described.
ChemInform Abstract: Enantioselective Hydrosilylation of Aromatic Alkenes Catalyzed by Chiral Bis(oxazolinyl)phenyl—Rhodium Acetate Complexes.
Authors: Naito Tatsuo , Yoneda Takuma , Ito Jun‐ichi , Nishiyama Hisao
Published: April 2013

Regio‐ and enantioselective hydrosilylation of alkenes is achieved using triethoxysilane in the presence of a chiral Rh‐complex catalyst.
ChemInform Abstract: Highly Reactive, Single‐Component Nickel Catalyst Precursor for Suzuki—Miyaura Cross‐Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides.
Authors: Ge Shaozhong , Hartwig John F.
Published: April 2013

The catalyst is stable enough to be weighed under air.
ChemInform Abstract: Synthesis of Pyrimidine‐Modified NHC Ruthenium‐Alkylidene Catalysts and Their Application in RCM, CM, EM and ROMP Reactions.
Authors: Wu Guang‐Long , Cao Sheng‐Li , Chen Jian , Chen Zili
Published: April 2013

Novel catalysts (I) and (II) are developed and shown to be significantly more active than the parent Hoveyda catalyst in the title reactions.
ChemInform Abstract: Synthesis of a Novel Non‐Benzenoid Quinone, 3,10‐Dihydro‐2,4‐dimethyl‐7,13‐methanocyclohepta [11]‐annulene‐3,10‐dione (VI), from 8H‐7,9‐Bis(methoxycarbonyl)‐5,11‐methano[11]annuleno[c]furan‐8‐one (I)
Authors: Kuroda Shigeyasu , Matsumoto Naoko , Zhang Yanmei , Miyatake Ryuta , Fujiwara Yurie , Oda Mitsunori
Published: April 2013

[via [4 + 3] cycloaddition of (I) with an oxyallyl species generated from dibromopentanone (II) as the crucial step].
ChemInform Abstract: The First Practical Additive‐Free 1,4‐Conjugated Alkylation of Fluoroalkylated Electron‐Deficient Olefins with Various Organozinc Reagents.
Authors: Morigaki Atsunori , Miyabe Tomotsugu , Tsukade Kazuki , Arimitsu Satoru , Ishihara Takashi , Konno Tsutomu
Published: April 2013

Reactions employing dialkylzinc provide the corresponding products in moderate to good yield.
ChemInform Abstract: CuI‐Mediated Trifluoromethylations with Stannanes.
Authors: Sanhueza Italo A. , Nielsen Mads C. , Ottiger Marcel , Schoenebeck Franziska
Published: April 2013

(Trifluoromethyl)stannane reagents, such as Bu3SnCF3 (II), are found to be effective trifluoromethylation agents in CuI‐mediated transformations of aryl iodides (I).
ChemInform Abstract: Regioselective Aromatic Nucleophilic Substituted in N‐Aryl‐2‐nitrosoanilines with Oxygen and Nitrogen Nucleophiles.
Authors: Wrobel Zbigniew , Stachowska Karolina , Kwast Andrzej
Published: April 2013

Exclusive nucleophilic substitution of the leaving group para to the nitroso function takes place and renders possible the access to products which cannot be prepared by known methods.
ChemInform Abstract: Copper‐Catalyzed C—H Azidation of Anilines under Mild Conditions.
Authors: Tang Conghui , Jiao Ning
Published: April 2013

A novel, practical, regiospecific, and efficient azidation of simple and readily available anilines is reported by using an inexpensive catalyst.
ChemInform Abstract: Graphene Oxide as Catalyst for the Acetalization of Aldehydes at Room Temperature.
Authors: Dhakshinamoorthy Amarajothi , Alvaro Mercedes , Puche Marta , Fornes Vicente , Garcia Hermenegildo
Published: April 2013

Graphene oxide is an efficient reusable catalyst for the acetalization of aldehydes.
ChemInform Abstract: Regio‐ and Stereocontrolled Reaction of Arenes with Ethyl Propiolate Catalyzed by Palladium or Platinum Complexes with a Bidentate Phosphine Ligand. An Efficient and Straightforward Synthesis of (1Z,3E)‐1‐Aryl‐1,3‐butadienes.
Authors: Oyamada Juzo , Sakai Mariko , Yamada Yasunori , Kitamura Tsugio
Published: April 2013

The regio‐ and stereoselective addition of arenes (I) to propiolate (II) is confirmed by NMR spectroscopy and X‐ray analysis of the products.
ChemInform Abstract: Metal Catalyst‐Free Amination of 2‐Chloro‐5‐nitrobenzoic Acid in Superheated Water.
Authors: Lan Cong , Xia Zhi‐Ning , Li Zheng‐Hua , Liang Rong‐Hui
Published: April 2013

The environmentally‐friendly method can be successfully extended to reactions of 2‐chloro‐5‐nitrobenzoic acid with phenol and thiophenol.
ChemInform Abstract: Intramolecular Cyclization of γ‐Acetylenic Acids Using Dendrimer‐Encapsulated Pd2+ Catalysts.
Authors: Maeno Zen , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi
Published: April 2013

The polypropylene imine dendrimer (Gx‐TEBA)‐encapsulated Pd catalysts are prepared by complexation of PdCl2 with internal tertiary amino groups and can be applied to induce the intramolecular cyclization of acetylenic acids.
ChemInform Abstract: Synthesis of Oxindole‐Appended Allyl Amines and Vinyl Aziridines via InCl3/ArSH‐Mediated Ring Opening of Vinyl Aziridines and Sulfur Ylide Aziridination.
Authors: Lingam Kandapalam Arun Prasath , Shammugam Ponnusamy , Mandal Asit Baran
Published: April 2013

Diastereoselective sulfur ylide aziridination of substrates (I) with N‐tosylamines provides synthetically important vinyl aziridines as (E) and (Z) isomers.
ChemInform Abstract: Palladium‐Catalyzed Direct C‐2 Arylation of Indoles with Aryl Halides in Aqueous Medium.
Authors: Lu Guo‐ping , Cai Chun
Published: April 2013

Various indole substrates can be efficiently arylated in a regio‐ and chemoselective manner in the absence of any toxic solvents.
ChemInform Abstract: Intramolecular Dehydrogenative Coupling of sp2 C—H and sp3 C—H Bonds: An Expeditious Route to 2‐Oxindoles.
Authors: Ghosh Santanu , De Subhadip , Kakde Badrinath N. , Bhunia Subhajit , Adhikary Amit , Bisai Alakesh
Published: April 2013

This method yields 2‐oxindoles with all‐carbon quarternary stereocenters at the pseudobenzylic position.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular C3 Alkenylation of Indoles Using Oxygen as the Oxidant.
Authors: Chen Wen‐Liang , Gao Ya‐Ru , Mao Shuai , Zhang Yan‐Lei , Wang Yu‐Fei , Wang Yong‐Qiang
Published: April 2013

The present new alkenylation reaction proceeds with complete regio‐ and stereoselectivity affording the E‐isomers exclusively at the C3‐position.
ChemInform Abstract: Rhodium(II) Catalyzed Diastereoselective Reactions of Diazoacetamides with Isatins: An Efficient Approach to 3‐Hydroxy‐3,3′‐bioxindoles.
Authors: Li Ming , Zhan Li , Prajapati Dipak , Hu Wenhao
Published: April 2013

A novel and mild alternative route to hydroxyl bisoxindoles is presented.
ChemInform Abstract: Asymmetric Proline‐Catalyzed Addition of Aldehydes to 3H‐Indol‐3‐ones: Enantioselective Synthesis of 2,3‐Dihydro‐1H‐indol‐3‐ones with Quaternary Stereogenic Centers.
Authors: Rueping Magnus , Rasappan Ramesh , Raja Sadiya
Published: April 2013

The proline‐catalyzed addition of various aliphatic aldehydes (II) and (IV) to sterically hindered 2‐arylindol‐3‐ones (I) and (VI) affords 2,2‐disubstituted indol‐3‐one derivatives (III) and (V) with high enantioselectivity.
ChemInform Abstract: Diels—Alder Reactions of 2‐Vinylindoles with Cyclic Dienophiles: Synthesis of [c]‐Annulated Tetrahydrocarbazoles.
Authors: Pirovano Valentina , Abbiati Giorgio , Dell'Acqua Monica , Facoetti Diego , Giordano Mara , Rossi Elisabetta
Published: April 2013

The reaction proceeds with excellent regioselectivity to give diastereomeric mixtures of pharmaceutically important tetrahydrocarbazole structures annullated with furan or carbocycle moieties, which are readily separable by chromatography.
ChemInform Abstract: Rapid Assembly of Polycyclic Structures via Sigmatropic Rearrangement of S‐Propargyl Xanthates.
Authors: Harrington Ryan M. , Wright David , Zard Samir Z.
Published: April 2013

Propargyl xanthates undergo rearrangement to afford intermediary bis(alkylidene)dithiolanones which are trapped by Diels‐Alder cycloaddition to yield dithiolones, representing three new carbocycle types such as (II), (VIII), and (X).
ChemInform Abstract: Synthesis of Highly Functionalized 1,3‐Oxathioles via an Unusual [4 + 1] Annulation of α,α′‐Dioxothione with 1,2‐Diaza‐1,3‐dienes.
Authors: Attanasi Orazio A. , Favi Gianfranco , Mantellini Fabio , Menichetti Stefano , Moscatelli Giada , Viglianisi Caterina
Published: April 2013

Reaction of α,α‐dioxothione, generated in situ from precursor (I) with 1,2‐diaza‐1,3‐dienes, affords the expected 1,3‐oxathioles.
ChemInform Abstract: One‐Pot, Three‐Step Reaction of 5‐[(Trimethylsilyl)ethynyl]pyrrolidin‐2‐one with Azides Catalyzed by CuI: Synthesis of a Novel Class of 1,4‐Disubstituted 1,2,3‐Triazoles.
Authors: Stefani Helio A. , Ferreira Fernando P. , Vieira Adriano S.
Published: April 2013

A very fast, easy, and efficient synthesis of a novel and biologically important class of disubstituted triazoles by an ultrasound‐assisted one‐pot, three‐step click reaction sequence is described.
ChemInform Abstract: Oxidative Dimerization of Isoflavones: Synthesis of Kudzuisoflavone A and Related Compounds.
Authors: Deodhar Mandar , Wood Kasey , Black David StClair , Kumar Naresh
Published: April 2013

A facile method for the oxidative dimerization of methoxy‐substituted isoflavones is presented.
ChemInform Abstract: Synthesis, Characterization, and in vitro Microbial Evaluation of Some New 4H‐Chromene and Quinoline Derivatives of 1H‐Pyrazole.
Authors: Thumar Nilesh J. , Patel Manish P.
Published: April 2013

Title compounds (IV) and (VI) are obtained by three‐component, one‐pot cyclocondensation reactions.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 204. Synthesis, Bromination, and Analgetic Properties of 1‐Allyl‐4‐hydroxy‐6,7‐dimethoxy‐2‐oxo‐1,2‐dihydroquinoline‐3‐carboxylic Acid Arylalkylamides.
Authors: Ukrainets I. V. , Mospanova E. V. , Jaradat N. A. , Bevz O. V. , Turov A. V.
Published: April 2013

A simple method for the synthesis of the title amides (III) (21 examples) is given.
ChemInform Abstract: Copper‐Catalyzed C—C Bond Cleavage and Intramolecular Cyclization: An Approach Toward Acridones.
Authors: Zhou Wang , Yang Youqing , Liu Yong , Deng Guo‐Jun
Published: April 2013

A new approach for the synthesis of acridones is developed utilizing a Cu‐catalyzed C—C bond cleavage of o‐arylaminophenyl methyl ketones and subsequent intramolecular cyclization using air as oxidant.
ChemInform Abstract: Facile Synthesis of Fully Substituted Dihydro‐β‐carbolines via Broensted Acid Promoted Cascade Reactions of α‐Indolyl Propargylic Alcohols with Nitrones.
Authors: Wang Lu , Xie Xin , Liu Yuanhong
Published: April 2013

Highly substituted β‐carbolines are a common motif in alkaloids.
ChemInform Abstract: Expedient Approach to Novel N‐Unprotected Bicyclic Azapyrimidine and Pyridine Structures.
Authors: Liu Zhibo , Qin Ling , Zard Samir Z.
Published: April 2013

Novel bicyclic N‐unprotected azapyrimidine structures are directly synthesized by the present new method involving radical addition and cyclization of xanthates.
ChemInform Abstract: Synthesis, Photophysical Properties, and Antimicrobial Activity of Novel Styryl Colorants Derived from 7‐Methoxy‐1,4‐diphenethyl‐1,2,3,4‐tetrahydroquinoxaline‐6‐carbaldehyde.
Authors: Jarag K. J. , Jagtap A. R. , Borse B. N. , Shukla S. R. , Shankarling G. S.
Published: April 2013

A small group of novel orange to violet styryl colorants (VII) is prepared using an innovative reductive alkylation reaction to (III) as key step.
ChemInform Abstract: Synthesis of 4H‐Pyrazino[1,2‐a]pyrimidine‐4,9(8H)‐diones and Imidazo[1,2‐a]pyrazin‐8(7H)‐ones.
Authors: Raubo Piotr , Ladwa Neal
Published: April 2013

Microwave‐assisted condensation of pyrazinones with β‐keto esters or α‐haloketones results in formation of the heterocyclic title systems, suitable as candidates for drug research.
ChemInform Abstract: Synthesis of Imidazo[4,5‐e][1,3]thiazolo‐[3,2‐b][1,2,4]triazines
Authors: Gazieva G. A. , Poluboyarov P. A. , Nelyubina Yu. V. , Struchkova M. I. , Kravchenko A. N.
Published: April 2013

via regioselective S‐alkylation of perhydroimidazotriazinethiones with bromoacetic acid
ChemInform Abstract: A One‐Pot Transition Metal Free Tandem Process to 1,4‐Benzodiazepine Scaffolds.
Authors: Li Yanqiu , Zhan Chunjing , Yang Bingchuan , Cao Xiaoqun , Ma Chen
Published: April 2013

A facile synthesis is achieved by base‐mediated reaction of 2‐aminobenzamides with dihalobenzenes or halonitrobenzenes.
ChemInform Abstract: Transition Metals in Organic Synthesis. Part 104. Iron‐Mediated Total Synthesis of Furoclausine‐A.
Authors: Krahl Micha P. , Schmidt Arndt W. , Knoelker Hans‐Joachim
Published: April 2013

Title compound (I) is synthesized starting from 2‐methyl‐5‐nitrophenol convergent in 7 steps and 7% overall yield using iron‐mediated coupling reactions.
ChemInform Abstract: Chemical Vapor Transport Reactions — A Historical Review
Authors: Binnewies Michael , Glaum Robert , Schmidt Marcus , Schmidt Peer
Published: April 2013

Review: 84 refs.
ChemInform Abstract: Tailored Crystalline Microporous Materials by Post‐Synthesis Modification
Authors: Valtchev Valentin , Majano Gerardo , Mintova Svetlana , Perez‐Ramirez Javier
Published: April 2013

Review: 374 refs.
ChemInform Abstract: Variation of Structural Motifs in Lanthanoid Hydroxo Clusters by Ligand Modification
Authors: Andrews Philip C. , Gee William J. , Junk Peter C. , Massi Massimiliano
Published: April 2013

Review: 70 refs.
ChemInform Abstract: Phthalocyanines and Related Compounds with Chalcogen Functional Groups
Authors: Kimura Takeshi
Published: April 2013

Review: synthesis and characterization; 135 refs.
ChemInform Abstract: Recent Progress Towards Transition Metal‐Catalyzed Direct Conversion of Cellulose to 5‐Hydroxymethylfurfural
Authors: Li Hu , Chang Fei , Zhang Yuping , Hu Deyu , Jin Linhong , Song Baoan , Yang Song
Published: April 2013

Review: 108 refs.
ChemInform Abstract: The Evolution of Immobilized Reagents and Their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds
Authors: Myers Rebecca M. , Roper Kimberley A. , Baxendale Ian R. , Ley Steven V.
Published: April 2013

Review: 77 refs.
ChemInform Abstract: Fluorous Linker‐Facilitated Synthesis of Biologically Interesting Molecules
Authors: Zhang Wei
Published: April 2013

Review: 69 refs.
ChemInform Abstract: Golden Opportunities in the Synthesis of Natural Products and Biologically Active Compounds
Authors: Gagosz Fabien
Published: April 2013

Review: 129 refs.
ChemInform Abstract: Design and Synthesis of Phosphite Ligands for Homogeneous Catalysis
Authors: Gual Aitor , Godard Cyril , de la Fuente Veronica , Castillon Sergio
Published: April 2013

Review: 316 refs.
ChemInform Abstract: Liquid Crystalline Catenanes and Rotaxanes
Authors: Sakuda Junji , Yasuda Takuma , Kato Takashi
Published: April 2013

Review: 67 refs.
ChemInform Abstract: Sirtuins as Emerging Antiparasitic Targets
Authors: Zheng Weiping
Published: April 2013

Review: 112 refs.
ChemInform Abstract: Small‐Molecule Lipid‐Bilayer Anion Transporters for Biological Applications
Authors: Busschaert Nathalie , Gale Philip A.
Published: April 2013

Review: 44 refs.
ChemInform Abstract: His‐Rich Sequences — Is Plagiarism from Nature a Good Idea?
Authors: Rowinska‐Zyrek Magdalena , Witkowska Danuta , Potocki Slawomir , Remelli Maurizio , Kozlowski Henryk
Published: April 2013

Review: 136 refs.
ChemInform Abstract: William Lawrence Bragg: The Pioneer of X‐Ray Crystallography and His Pervasive Influence.
Authors: Thomas John Meurig
Published: April 2013

Review: 70 refs.
ChemInform Abstract: Luminescent Chemosensors Based on Silica Nanoparticles for the Detection of Ionic Species
Authors: Montalti Marco , Rampazzo Enrico , Zaccheroni Nelsi , Prodi Luca
Published: April 2013

Review: 43 refs.
ChemInform Abstract: The Mechanism of the Pauson—Khand Reaction: Hypothesis Experimental Facts, and Theoretical Investigations
Authors: Cambeiro Xacobe C. , Pericas Miquel A.
Published: April 2013

Review: 60 refs.
ChemInform Abstract: The Pauson—Khand Reaction: An Introduction
Authors: Kerr William J.
Published: April 2013

Review: 121 refs.
ChemInform Abstract: NMR in Organic Chemistry
Authors: Courtieu Jacques , Giraud Nicolas , Lafon Olivier , Lesot Philippe , Lorthioir Cedric , Nuzillard Jean‐Marc
Published: April 2013

Review: 19 refs.
Magnetically Separable Water Treatment Technologies and their Role in Future Advanced Water Treatment: A Patent Review
Authors: Linley Stuart , Leshuk Timothy , Gu Frank X.
Published: April 2013

Magnetic separation has been recognized as an important property for the simple deployment of micro and sub‐microparticles into solution in the field of water treatment. Many materials with desirable properties for water decontamination are hindered due to the difficulty inherent in removing them from solution post‐treatment. By securing these materials to magnetic compounds, this important issue can be solved as removing active materials from wastewater requires only the application of a magnetic field. This review article presents and discusses many recent technologies, in the form of patents, which exploit the property of magnetic separation for advanced water treatment, including methods of adsorbing pollutants from wastewater and magnetically separating them, as well as methods of deploying active materials for the degradation of contaminants, then magnetically retrieving these catalysts. The requirement for advanced wastewater treatment methods becomes more essential as new, persistent contaminants arise as a result of pharmaceuticals, pesticides and industrial processes which cannot be addressed by traditional water treatment procedures. Magnetic separation promises to be a critical factor in these advanced methods, allowing the safe deployment of active materials which would otherwise be unusable, opening the gate to more efficient, economic and environmentally friendly water purification.
Optimization of Removal of Phenol from Aqueous Solution by Ionic Liquid‐Based Emulsion Liquid Membrane Using Response Surface Methodology
Authors: Balasubramanian Arulmozhiappan , Venkatesan Sivaramu
Published: April 2013

Response surface methodology was employed to optimize the removal of phenol from aqueous solution by ionic liquid (1‐butyl‐3‐methylimidazolium hexafluorophosphate dissolved in tributyl phosphate) based emulsion liquid membrane. A “minimum run resolution V” central composite design with six variables (surfactant concentration, internal phase concentration, emulsification time, internal to membrane phase ratio, stirring speed and external phase pH) was applied to optimize the process. The optimized conditions for maximum removal of phenol were a surfactant concentration – 4.95% (v/v), internal agent concentration – 0.298 N, emulsification time – 4.07 min, internal to membrane phase ratio – 0.93, stirring speed – 247 rpm and external phase pH – 5.91 respectively. The results showed good fits with the proposed statistical model for removal of phenol (R2 = 0.9833).
The Effect and Mechanism of UV Disinfection on the Inactivation of a Planktonic Freshwater Copepods (Limnoithona sinensis)
Authors: Lin Tao , Zhang Jian , Chen Wei , Sun Ying
Published: April 2013

Bench‐scale experiments were conducted to evaluate effects of UV radiation (UVR) on Limnoithona sinensis (Copepoda, Crustacea). Results showed that water depth, wavelength, and irradiation time significantly reduced the swimming activity of L. sinensis. The inactivation rate increased with irradiation time, and there was an inverse relation between inactivation rate and water depth. Positive phototaxis was observed in copepods exposed to visible light with wavelengths of 480 or 500 nm, which caused a substantial increase in the inactivation rate when UVR was combined with visible light. Scanning electron microscopy showed that the skin of L. sinensis inactivated by UVR appeared dry and wrinkled, which was possibly due to induction of osmotic changes across cell membranes. As indicated by three‐dimensional fluorescence spectra showing leakage of protoplasm to the external environment.
Synthesis and Cytostatic and Antiviral Activities of 2′‐Deoxy‐2′,2′‐difluororibo‐ and 2′‐Deoxy‐2′‐fluororibonucleosides Derived from 7‐(Het)aryl‐7‐deazaadenines
Authors: Perlíková Pavla , Eberlin Ludovic , Ménová Petra , Raindlová Veronika , Slavětínská Lenka , Tloušťová Eva , Bahador Gina , Lee Yu‐Jen , Hocek Michal
Published: April 2013

A series of sugar‐modified derivatives of cytostatic 7‐heteroaryl‐7‐deazaadenosines (2′‐deoxy‐2′‐fluororibo‐ and 2′‐deoxy‐2′,2′‐difluororibonucleosides) bearing an aryl or heteroaryl group at position 7 was prepared and screened for biological activity. The difluororibonucleosides were prepared by non‐ stereoselective glycosidation of 6‐chloro‐7‐deazapurine with benzoyl‐protected 2‐deoxy‐2,2‐difluoro‐D‐erythro‐pentofuranosyl‐1‐mesylate, followed by amination and aqueous Suzuki cross‐couplings with (het)arylboronic acids. The fluororibo derivatives were prepared by aqueous palladium‐catalyzed cross‐coupling reactions of the corresponding 7‐iodo‐7‐deazaadenine 2′‐deoxy‐2′‐fluororibonucleoside 20 with (het)arylboronic acids. The key intermediate 20 was prepared by a six‐step sequence from the corresponding arabinonucleoside by selective protection of 3′‐ and 5′‐hydroxy groups with acid‐labile groups, followed by stereoselective SN2 fluorination and deprotection. Some of the title nucleosides and 7‐iodo‐7‐deazaadenine intermediates showed micromolar cytostatic or anti‐HCV activity. The most active were 7‐iodo and 7‐ethynyl derivatives. The corresponding 2′‐deoxy‐2′,2′‐difluororibonucleoside 5′‐O‐triphosphates were found to be good substrates for bacterial DNA polymerases, but are inhibitors of human polymerase α.