bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular and biochemical analyses of avocado (Persea americana) reveal differences in the oil accumulation pattern between the mesocarp and seed during the fruit developmental period
Authors: Ge Yu , Dong Xiangshu , Liu Yuanzheng , Yang Ying , Zhan Rulin
Published: April 2020

Background: The avocado (Persea americana) mesocarp and seed contain high-value oil with broad industrial applications. The oil contents in these two tissues vary considerably at maturity. Additionally, the molecular mechanism underlying the tissue-specific oil accumulation in the developing avocado mesocarp and seed remains unclear, which has hampered the exploration of the utility of avocado for oil production.Results: To clarify the mechanisms mediating the differences in oil contents and fatty acid compositions, the transcriptomes and oil bodies were compared between the oil-storing tissues during the fruit developmental period. The results revealed the increasing and fluctuating trends in the oil accumulation in the developing avocado mesocarp and seed, respectively. Additionally, striking differences in the lipid droplets between the mature mesocarp and seed were revealed in confocal microscopy images. Subsequently, the gene transcription profiles of the developing mesocarp and seed were characterized via a comprehensive transcriptome analysis involving second-generation sequencing and single-molecule real-time sequencing techniques. The tissue-specific transcription of lipid-related genes contributing to fatty acid synthesis, triacylglycerol assembly, and triacylglycerol storage was examined, with most of the lipid-related genes expressed at higher levels in the developing mesocarp than in the developing seed. A weighted gene co-expression network analysis uncovered 291 transcription factors that were commonly or uniquely correlated with the oil contents in the avocado mesocarp and seed. Moreover, 11 trans-acting and 79 cis-acting long non-coding RNAs were identified as common or unique to the developing avocado mesocarp and seed. These long non-coding RNAs may regulate the expression of 43 lipid-related genes. Finally, a network of genes associated with oil accumulation in the developing avocado mesocarp and seed was established.Conclusions: The results of this study further elucidate the tissue-specific oil biosynthesis and related regulatory network in the avocado mesocarp and seed. Furthermore, tissue-specific lipid-related genes, putative transcription factors, and putativelong non-coding RNAs affecting oil accumulation were identified. Our data may also be useful for characterizing tissue-specific oil accumulation at the transcriptomic level, thereby identifying candidate genes for improving the oil production of related plant species.
Radiotherapy in benign pathology: treatment of lymphorrheas
Authors: Cañon Veronica , Anchuelo Javier , Sierrasesumaga Nicolas , Alonso Lucia , Rivero Ana , Galdos Piedad , cerio Ivan Diaz de , Garcia Ana , Ferri Maria , Cardenal Juan , Vidal Hector , Fabregat Rosa , Ruiz Samuel , Prada Pedro Jose
Published: April 2020

Objective : To aim of the study is to determine the efficacy and safety of treatment with low-dose 3D external beam radiotherapy (EBRT) in patients with inguinal lymphorrhea. Material and methods : We retrospectively analyzed a total of 53 patients with persistent lymphorrhea after conservative treatment between 2008 and 2018. All patients were treated with 3D EBRT with photons of 6 - 18 MeV. The most common schedules were 7.5 Gy in 5 fractions (90.7%). Results : The complete closure of the fistula was achieved in 100% (43/43) of the patients. Three patients required re-irradiation due to persistence. We did not find any acute toxicity. Conclusions : Low-dose radiation therapy is effective and safe for treating persistent lymphorrheas.
miR-29a overexpresion induces apoptosis through targeting VEGF in hepatocellular carcinoma
Authors: Wang An-ji , Wu Hua-jun , Yuan Chun-hui , Ning Ke , Hu Huan-huan , Wang Chao , Yin Xiang-bao
Published: April 2020

Background : This study aimed to explore the role of miR-29a in hepatocellular carcinoma (HCC) cells. Further, to confirm whether miR-29a targetes vascular endothelial growth factor (VEGF) in HCC cells. Methods: Cell counting Kit-8 (CCK8) and clone formation assay were used to analyze the proliferation of HCC cells. Flow cytometry was performed to analyze the apoptosis and cell cycle of HCC cells. Western blot was used to analyze the expression of Bax, B-cell lymphoma-2 (Bcl-2), cyclin dependent kinase 4 (CDK4), CyclinD1, Retinoblastoma (Rb), p53 and myeloid cell leukemia-1 (MCL1). The targeting relations between miR-29a and VEGF was measuered by dual luciferase assay. Results : Overexpression of miR-29a could distinctly inhibit the proliferation and promote apoptosis of HCC cells. Overexpression of miR-29a obviously up-regulated the expressions of Bax and Rb, and reduced the expressions of CDK4, Bcl-2, Cyclin D1, p53, MCL1 and VEGF in HCC cells. Dual luciferase assay proved that VEGF was the target of miR-29a. Rescue experiments showed that miR-29a targeted VEGF to regulate the proliferation and apoptosis in HCC cells. Conclusions : These results indicated overexpression of miR-29a inhibited the HCC cells proliferation through targeting VEGF.
CT features and artificial intelligence quantitative analysis of recovered COVID-19 patients with negative RT-PCR and clinical symptoms
Authors: Du Siyao , Gao Si , Huang Guoliang , Li Shu , Chong Wei , Jia Ziyi , Hou Gang , Zhang Lina
Published: April 2020

Objectives: To evaluate imaging features and performed quantitative analysis for mild novel coronavirus pneumonia (COVID-19) cases ready for discharge.Methods: CT images of 125 patients (16-67 years, 63 males) recovering from COVID-19 were examined. We defined the double-negative period (DNp) as the period between the sampling days of two consecutive negative RT-PCR and three days thereafter. Lesion demonstrations and distributions on CT in DNp (CTDN) were evaluated by radiologists and artificial intelligence (AI) software. Major lesion transformations and the involvement range for patients with follow-up CT were analyzed.Results: Twenty (16.0%) patients exhibited normal CTDN; abnormal CTDN for 105 indicated ground-glass opacity (GGO) (99/125, 79.2%) and fibrosis (56/125, 44.8%) as the most frequent CT findings. Bilateral-lung involvement with mixed or random distribution was most common for GGO on CTDN. Fibrous lesions often affected both lungs, tending to distribute on the subpleura. Follow-up CT showed lesion improvement manifesting as GGO thinning (40/40, 100%), fibrosis reduction (17/26, 65.4%), and consolidation fading (9/11, 81.8%), with or without range reduction. AI analysis showed the highest proportions for right lower lobe involvement (volume, 12.01±35.87cm3; percentage; 1.45±4.58%) and CT-value ranging –570 to –470 HU (volume, 2.93±7.04cm3; percentage, 5.28±6.47%). Among cases with follow-up CT, most of lung lobes and CT-value ranges displayed a significant reduction after DNp.Conclusions: The main CT imaging manifestations were GGO and fibrosis in DNp, which weakened with or without volume reduction. AI analysis results were consistent with imaging features and changes, possibly serving as an objective indicator for disease monitoring and discharge.
Estimated Implementation Costs of DNA-informed Breeding in a Peach Breeding Program
Authors: Wannemuehler Seth D. , Yue Chengyan , Shane William W. , Gallardo R. Karina , McCracken Vicki
Published: April 2020

Marker-assisted selection (MAS) use in breeding programs allows for examination of seedlings at an early stage before accumulation of high field costs. However, introducing MAS into a breeding program implies additional costs and uncertainties about effective incorporation. Previous simulations in apple (Malus ×domestica) have shown cost-effective applications of MAS. To further evaluate MAS cost-effectiveness in perennial crops, we conducted a cost-effectiveness analysis examining MAS in an upper midwestern U.S. peach (Prunus persica) breeding program. Breeding program procedures and associated costs were collected and used as input into spreadsheet-based simulations of the breeding program. Simulations compared a conventional breeding program to MAS with varying cull rates of low, medium, and high at multiple stages in the breeding cycle. Cost-effective MAS implementation was identified at the end of seedling trials with a break-even cull rate of 4%. These results inform breeders of cost-effectiveness of MAS use in a peach breeding program.
ESTIMATION OF OXIDATIVE STABILITY OF THE LIPID COMPLEX OF CREAMY-SHAKEN CANDIES WITH CHIA SEEDS AT STORAGE
Authors: Shydakova-Kameniuka Оlena , Shkliaiev Oleksii , Samokhvalova Olga , Artamonova Maya , Stepankova Galyna , Bolkhovitina Olena , Rogova Alla
Published: April 2020

One of ways of developing the confectionary industry is a search for raw material resources with a high content of nutrients, useful for the human organism. A promising type of such raw materials is non-traditional oil seeds, especially chia seeds. The aim of the study was to estimate the oxidative stability of the lipid complex of creamy-shaken candies with chia seeds at storage. It is noted, that lipase of chia seeds doesn’t manifest activity in an acid medium. That is why chia seeds introduction to creamy-shaken candies (with рН<6,0) doesn’t accelerate hydrolytic disintegration of their lipid component at storage. A type of jelly-former, used at candy production (agar-agar, pectin, modified starch), doesn’t influence the accumulation dynamics of free fatty acids in candies. It is noted, that the lipid component of creamy-shaken candies, produced with agar-agar and pectin, is characterized with the equal dynamics of a peroxide value. The accumulation of peroxide compounds in starch products takes place slower. It has been established, that despite the high content of polyunsaturated fatty acids, the lipid component of candies with chia seeds comparing with control is characterized by less inclination to oxidation. It is noted, that at the 30th day of storage relative changes of peroxide value indices of products with supplements are 1.00 and 0.81 against 1.85 and 1.49 in control samples on agar-agar (pectin) and starch respectively. The braking effect of chia seeds on oxidizing processes is conditioned by the high content of tocopherols and phenol compounds (quercetin, coffee, chlorogenic acids, rutin, polyphenol compounds) with antioxidant properties in them.

It has been established, that during the studied storage term products didn’t gain a rancid smack, testifying to the accumulation of secondary oxidation processes. The structure and color of the studied samples of candies didn’t also change. That is during the normative storage term (60 days) creamy-shaken candies with chia seeds correspond to normative requirements by organoleptic parameters and quality ones of the lipid complex.
Uji Antifungi Susu Fermentasi Komersial pada Candida non-albicans
Authors: Khikmah Nur , Sulistyani Nunung
Published: April 2020

Bakteri Asam Laktat (BAL) yang terkandung dalam susu fermentasi akan menghasilkan asam-asam organik, hidrogen peroksida, diasetil, asetaldehid, asetoin, reutinin, reuterisiklin dan bakteriosin, dapat sebagai anti-Candida. Spesies Candida non-albicans seperti C. tropicalis dan C. glabrata sebagai penyebab kandidiasis oral cenderung meningkat. Tujuan penelitian ini mengetahui aktivitas antifungi susu fermentasi komersial pada Candida non-albicans dan viabilitas bakteri asam laktat di dalam susu fermentasi komersial. Aktivitas antifungi pada Candida non-albicans dilakukan dengan metode difusi sumuran. Viabilitas bakteri asam laktat dihitung berdasarkan jumlah bakteri asam laktat sebagai jumlah bakteri total (Total Plate Count). Hasil penelitian menunjukkan bahwa susu fermentasi komersial lebih mampu menghambat C. tropicalis dibandingkan C. glabrata. Viabilitas bakteri asam laktat dalam susu fermentasi komersial 107-1010 CFU/mL.

Lactic Acid Bacteria (LAB) contained in fermented milk will produce organic acids, hydrogen peroxide, diacetyl, acetaldehyde, acetoin, reutinin, reuterycline and bacteriocin, as anti-Candida. Candida non-albicans species such as C. tropicalis and C. glabrata as causes of oral candidiasis tend to increase. The aim of this research was to determine the antifungal activity of commercial fermented milk against Candida non-albicans and viability of lactic acid bacteria in commercial ermented milk. The antifungal activity was determined using well diffusion method. Viability of lactic acid bacteria is calculated as Total Plate Count. The results showed that commercial fermented milk was more able to inhibit C. tropicalis compared C. glabrata. Viability of lactic acid bacteria 107-1010 CFU/mL.
Impact of organizational politics on proactive behavior of government employees: the moderating role of self-efficacy
Authors: Ali Rasyid Fauzan , Sandi Marta M
Published: April 2020

In today’s organizational environment, human resources are seen to be one of the most crucial assets that must be maintained, particularly the existence of employees’ proactive behavior, which is needed for the sustainability of organizational performance. One factor, which may affect the employees’ proactive behavior, is organizational politics. Therefore, the main objective of this study is to investigate the effect of organizational politics on proactive behavior of government employees and to test further whether this effect was moderated by self-efficacy. This study used a quantitative approach with an exploratory method to answer the proposed hypothesis. The samples were 310 local government employees in Bandung district, Cimahi City, Bandung City, and West Bandung Regency, Indonesia. For processing the data and testing the hypotheses, this research employed Moderated Regression Analysis by using STATA 13. The results showed that organizational politics has a negative effect on the proactive behavior of government employees, and the moderation effect of self-efficacy can weaken the negative relationship between organizational politics and proactive behavior. The study, therefore, makes a valuable contribution regarding the additional evidence to the organization within this field.
Transnationalism and borderlands: concepts of space on the US-Mexico border and beyond
Authors: Goldberg Anne J.
Published: April 2020

Transnationalism and Borderlands: Concepts of Space on the US-Mexico Border and Beyond. This paper problematizes the linkage between studies of international borders and studies of transnationalism. While obvious connections exist, the conceptualization of space by both actors and anthropologists creates a division in Nogales, Arizona, a town on the US-Mexico border and the site of an applied study of education. Implications of this theory for the stated research and for anthropology will be discussed.
Antropologia e alimentação
Authors: Tavares Thiago Rodrigues , Castro Vanessa Gomes de
Published: April 2020

A presente pesquisa visou observar, descrever e refletir sobre os momentos de comensalidade durante o Jubileu de São Miguel e Almas no Cemitério do Peixe. Comensalidade refere-se às relações culturais, sociais e políticas estabelecidas em torno dos atos de cozinhar, compartilhar e comer. O Jubileu é uma festa religiosa que acontece todos os anos, durante o mês de agosto, no vilarejo do Cemitério do Peixe, situado na cidade de Conceição do Mato Dentro/MG. Foram observados os modos de transporte e armazenamento, as comidas, bebidas e receitas, os utensílios utilizados na preparação e na higienização, o compartilhamento e a sociabilidade, as tradições e os papéis de gênero.
O carnivorismo ocidental
Authors: Leda Manuela Correa
Published: April 2020

O consumo de alimentos é uma das atividades mais elementares da existência humana, sendo seus aspectos materiais e simbólicos marcas históricas de diferenciações culturais entre diversos grupos étnicos e nações em todo o mundo. Desde que a globalização entrecruzou referências alimentares, a carne tornou-se um dos objetos de consumo mais desejados mundialmente e cujos padrões de ingestão tem crescido continuadamente, até mesmo em regiões tradicionalmente conhecidas por suas práticas vegetarianas. Essa mudança no cenário alimentar global tem sido acompanhado nas últimas décadas pela difusão de movimentos críticos que têm questionado os valores culturais e sociais do consumo de proteína animal em todo o mundo. Este artigo tem como objetivo compreender os principais aspectos culturais que influenciaram a ascensão do carnivorismo ocidental moderno e, a partir desse olhar, analisar os discursos mais recentes que vêm confrontando os efeitos dessa prática alimentar. A despeito de suas peculiaridades, observamos que esses movimentos estão transformando a carne em um importante objeto político e cujas disputas estão colocando em crise as bases culturais que sustentam nossos hábitos carnivoristas.
Chicha de jora:
Authors: Vargas Faulbaum Felipe
Published: April 2020

O cauim de milho germinado, chicha de jora ou aqha é uma bebida fermentada milenar e tradicional das terras altas andinas. Apresentamos uma investigação etnográfica da produção e consumo de chicha feita em comunidades camponesas andinas do departamento de Cusco, no Peru. Ressaltamos a estreita relação da chicha com o cultivo do milho, o oficio feminino da chichera, a função da chichería na coesão social das comunidades camponesas dos Andes. Analisamos as transformações e substituições causadas pela modernidade e pelo capitalismo na atual elaboração tradicional da chicha de jora. Procuramos contribuir na reavaliação desta tradicional bebida andina.
Comida de teranga:
Authors: Moreira Evelize Cristina , De Souza Maciel Maria Eunice
Published: April 2020

O artigo a seguir traz um recorte de trabalho de campo entre migrantes senegaleses wolof em Porto Alegre. Considerando a alimentação como um aspecto que vai além do âmbito biológico, mas principalmente, que traduz muito de nossos elementos culturais, trazemos um relato sobre a celebração do Grande Magal de Touba, ocorrida na capital gaúcha no dia 08 de novembro de 2017. O evento se configura como o maior e mais tradicional do ramo islâmico praticado pelos senegaleses em Porto Alegre. Como veremos, o espaço dessa celebração através da alimentação decodifica e comunica diversos aspectos da sociedade senegalesa e do islã mouridista.
"Fazendo a linha cdzinha": performance transidentitária de crossdressers brasileiras em Lisboa/PT
Authors: Azevedo Pietra
Published: April 2020

Cdzinha é uma palavra que representa o abrasileiramento da expressão crossdresser. Assim, este texto etnográfico baseia-se na observação participante e na participação observante realizada entre janeiro e agosto de 2017 na cidade de Lisboa/PT, junto a três cdzinhas brasileiras. O objetivo é compreender como se dá o processo de performatização da transidentidade delas. Neste sentido, refleti sobre questões como: as motivações da montação, o manejo sobre o corpo, o trânsito e fluidez entre os gêneros, a transidentidade performatizada a partir da alteridade com as travestis e as drag queens e o universo dos encontros das cdzinhas com seus parceiros sexuais-afetivos pensando o desejo por meio das resistências e dos assujeitamentos.
Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates
Authors: García-Borjas Karla Alejandra , Ceballos-Olvera Ivonne , Luna-Castro Sarahí , Peña-Avelino Yosahandy
Published: April 2020

Background:

Bovine Lactoferrin (bLf) has been reported as antimicrobial, antiviral,
immunomodulatory and anticancer protein. Escherichia coli and Listeria spp. are food-borne bacteria
that can produce illness in human being and mammals, the emergent antimicrobial drug resistance
has been reported in these pathogens.

Objective:

The aim for this study was to evaluate the bLf effect on in vitro biofilm production and
the synergic effect of antibiotics on E. coli and Listeria isolates.

Methods:

E. coli and Listeria specimens were isolated from bovine carcasses and slaughterhouses
surfaces, respectively. Biofilm formation was analyzed with or without bLf, incubated for 48 h and
spectrophotometry, cell viability was analyzed by colony-forming unit (CFU) and the synergistic
effect of bLf with ampicillin, oxytetracycline, and streptomycin was evaluated through the fractional
concentration index (FCI).

Results:

Our results show that a low bLf concentration (0.8 μM) can diminish the in vitro biofilm
production in Listeria isolates; also improves the in vitro oxytetracycline and streptomycin activity
against E. coli, and ampicillin activity against Listeria isolates.

Conclusion:

bLf can affect the biofilm production in Listeria isolates from slaughterhouses surfaces
and shown synergic effect with ampicillin. Also has a synergic effect with oxytetracycline
and streptomycin against E. coli isolates from bovine carcasses.
Therapeutic Potential of Phosphodiesterase Inhibitors for Endothelial Dysfunction- Related Diseases
Authors: Blanco-Rivero Javier , Xavier Fabiano E.
Published: April 2020

Cardiovascular diseases (CVD) are considered a major health problem worldwide, being the main cause of mortality in developing and developed countries. Endothelial dysfunction, characterized by a decline in nitric oxide production and/or bioavailability, increased oxidative stress, decreased prostacyclin levels, and a reduction of endothelium-derived hyperpolarizing factor is considered an important prognostic indicator of various CVD. Changes in cyclic nucleotides production and/ or signalling, such as guanosine 3', 5'-monophosphate (cGMP) and adenosine 3', 5'-monophosphate (cAMP), also accompany many vascular disorders that course with altered endothelial function. Phosphodiesterases (PDE) are metallophosphohydrolases that catalyse cAMP and cGMP hydrolysis, thereby terminating the cyclic nucleotide-dependent signalling. The development of drugs that selectively block the activity of specific PDE families remains of great interest to the research, clinical and pharmaceutical industries. In the present review, we will discuss the effects of PDE inhibitors on CVD related to altered endothelial function, such as atherosclerosis, diabetes mellitus, arterial hypertension, stroke, aging and cirrhosis. Multiple evidences suggest that PDEs inhibition represents an attractive medical approach for the treatment of endothelial dysfunction-related diseases. Selective PDE inhibitors, especially PDE3 and PDE5 inhibitors are proposed to increase vascular NO levels by increasing antioxidant status or endothelial nitric oxide synthase expression and activation and to improve the morphological architecture of the endothelial surface. Thereby, selective PDE inhibitors can improve the endothelial function in various CVD, increasing the evidence that these drugs are potential treatment strategies for vascular dysfunction and reinforcing their potential role as an adjuvant in the pharmacotherapy of CVD.
Coronary Calcium Risk Score and Cardiovascular Risk
Authors: Lehker Angelica , Mukherjee Debabrata
Published: April 2020

The association between the presence of coronary artery calcium (CAC) and the risk of coronary
artery disease (CAD) has been appreciated for decades. In this review, we critically appraise the
role of CAC based on computerized tomography in contemporary risk stratification. Available evidence
suggests that the measurement of CAC is a useful modality in many patients for more precise risk stratification
and prognostic determination. Whether newer CAC score incorporating extra coronary calcification
will add incremental value, especially for stroke and other non-coronary vascular outcomes,
needs a prospective study.
Nanoparticles for Sustainable Agriculture and their Effect on Plants
Authors: Srivastava Amrisha , Singh Rachana
Published: April 2020

Nano-biotechnology is gaing attention in the field of agriculture because of its different
applications such as release of nutrients, pesticides, nanosensors, veterinary care, detection of nutrient
deficiencies and many more. Nanoparticles, measured in nano size, is used in variety of forms to
improve the efficiency of nutrient utilization and reduces the costs of environmental protection. Nano
fertilizer, one of the important aspect of nanoparticles. It facilitates incorporation of measured
amount of nutrition to the crops which reduces the chance of nutrition loss, thus helps to improve
crop fertility. Toxic waste from soil and water can also be reduced by the use of different agrichemicals.
Nanotechnology has the potential to detect the disease at an early stage and also improves the
ability of plants to uptake nutrients, thus improving agriculture and food industry. This review covers
the use of different nanoparticles in agriculture as plant growth promoters and their use in controlling
plant diseases.
Electrospun Biodegradable Bi-Layered Microfiber Membranes for Aluminum Removal from Drinking Water
Authors: Sultana Naznin
Published: April 2020

Aims:

This study aimed to eliminate metallic contaminants from drinking water by using
electrospun bi-layered microfiber membranes.

Background:

Fast industrialization triggers environmental pollution. Heavy metals like silver, lead
and aluminum are the major contaminants that are extremely toxic and accumulate in biological tissues
through the food chain and cause a health hazard. Electrospinning is a promising technique
among other conventional techniques of removing these metals from drinking water. Electrospun
membranes possess suitable properties for microfiltration purposes. In this study, to fabricate electrospun
membranes, polycaprolactone (PCL) and zeolites were used as materials. PCL polymer is biocompatible
and biodegradable, and zeolite is microporous, which is good for filtration or molecular
sieving application.

Methods:

Using the electrospinning technique, PCL, PCL/zeolite, PCL and PCL/zeolite bi-layered
electrospun membranes were fabricated. The properties of the membranes were evaluated using different
techniques. The performance of the membranes was tested by filtering Aluminum (Al) present
in drinking water.

Results:

Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analyses confirmed
the removal of Al using the membranes. ICP-OES results showed above 90% of Al removal
using PCL and PCL/zeolite electrospun membrane.

Conclusion:

These membranes are non-toxic and biodegradable and have the potential to be used for
microfiltration purposes.
Effects of Pulmonary Vascular Resistance Index on Oxygen Saturation in Patients with Atrial Septal Defect
Authors: Supomo Supomo
Published: April 2020

Atrial septal defect (ASD) is a congenital lesion in atrium septum. The lesion may cause pulmonary hypertension due to the high pressure in the right ventricle. This condition leads to cyanosis in ASD patient, but the pathophysiology of cyanosis in ASD patient is still unknown. This study aimed to identify the pathophysiology of cyanosis in ASD patients using the Pulmonary Vascular Resistance index (PVRi). The design of this study was retrospective cohort study. The data used in this study were the results of right heart catheterization procedure taken from forty ASD patient medical records at Dr. Sardjito general hospital. The exclusions criteria were the history of previous vasodilator administration and incomplete medical records. The median age of the patients was 30 (18-55) years old. The mean of the Qp/Qs ratio was 1.210 (0.57-6.33). Optimum oxygen saturation was found in vessel leaving the heart. The PVRi median is 61.98 (-15.58-676.64). The PVRi has a significant correlation with oxygen saturation, except in the right atrium. There is a significant correlation between PVRi and oxygen saturation in various heart chambers. Pathophysiology of cyanosis in ASD patients is central cyanosis.
ЗАСТОСУВАННЯ МЕТОДУ «ПРОФЕСІЙНО-ПРАКТИЧНОЇ ЗДОРОВОЇ КОНКУРЕНЦІЇ» СЕРЕД СТУДЕНТІВ МЕДИЧНИХ ВУЗІВ.
Authors: Готюр О. І.
Published: April 2020

Резюме. На протязі 5-ти років мною були проведені спостереження за навчанням та успішністю студентів і зроблені відповідні висновки на основі яких я склала та пропоную до застосування метод під назвою – «Професійно-практичної здорової конкуренції» для контролю рівня практичної підготовки та стимуляції до індивідуального навчання студентів.

Мета: швидко та якісно допомогти студентам професійно оволодіти практичними навиками на муляжах у практично-тренінгових центрах.

Матеріали та методи. Я спостерігала за тими студентами які здавали зрізи практичних навиків у стандартному – демонстраційному режимі відтворення вивчених практичних навиків, це 126 студентів які увійшли у групу – Б (стандарт) та окремо – за 128 студентами які здавали зрізи практичних навиків за методикою – «Професійно-практичної здорової конкуренції» і увійшли у групу-А у кожному році відповідно.

Результати дослідження. Провівши аналіз результатів оцінювання зрізів практичних навиків, ми бачимо, що кількість «відмінних» оцінок значно більша у групах-А в порівнянні із групами-Б (стандарт) на різних роках спостереження.

Студенти групи-Б (стандарт) продемонстрували низьку підготовку до  демонстрації практичних навиків набравши у результаті двох основних зрізів практичних навиків високий відсоток «задовільних» та - «незадовільних» оцінок.

Висновки:

Методика «Професійно-практичної здорової конкуренції» у здачі практичних навиків показала позитивні результати у стимуляції студентів до індивідуальної підготовки до контролю здачі зрізів практичних навиків на ІІ курсі студентами медичного коледжу при Івано-Франківському Національному Медичному Університеті.
Температурная зависимость интенсивности селективного излучения линии R-=SUB=-1-=/SUB=- при лазерно-термическом нагреве рубина
Authors: Марченко В.М. , Шакир Ю.А.
Published: April 2020

Temperature dependence of intensity of R1 line selective emission at laser thermal heating of ruby was experimentally investigated and explained by competition of radiative and nonradiative processes.
Спектрально-люминесцентные свойства разнолигандных комплексных соединений европия(III) c o-метоксибензойной кислотой и фосфорсодержащими нейтральными лигандами
Authors: Калиновская И.В.
Published: April 2020

The spectral and luminescent properties of complex compounds of europium (III) with o-methoxybenzoic acid and island-containing phosphorus-containing neutral ligands of the composition Eu (MOBA) 3 • 3Н2О and Eu (MOBA) 3 • L, where MOBA is o-methoxybenzoic acid, D is studied (hexamethylphosphoric triamide), tppo (triphenylphosphine oxide), Et6pa (hexaethylphosphotriamide). It was found that the excitation energy is transferred to the europium ion both from the levels of o-methoxybenzoic acid and from the levels of phosphorus-containing neutral ligands.The electronic absorption spectra, the luminescence excitation spectra, and the Stark structure of 5D0-7Fj (j = 0-2) electronic transitions in the luminescence spectra of mixed-ligand complex europium (III) complex o-methoxybenzoates are analyzed. Europium (III) methoxybenzoate with triphenylphosphine oxide has the highest luminescence intensity.
Микроскопия с многофотонным возбуждением для идентификации и оперативного контроля компонентов внеклеточного матрикса тканей организма
Authors: Кистенев Ю.В. , Николаев В.В. , Борисов А.В. , Заева О.Б. , Князькова А.И. , Кривова Н.А.
Published: April 2020

The process of extraction of the extracellular matrix (ECM) requires operational monitoring since with non-optimal process parameters there is a risk of destruction of the basic proteins of the cell-matrix. Using multiphoton microscopy, the structure of collagen, the integrity of the cell membrane and the content of elastin in the process of isolation of ECM from various tissues of the rat organism (brain, dermis, muscle) were studied. It has been shown that multiphoton microscopy is an effective tool for monitoring the quality of ECM extraction.
Ранняя диагностика меланомы кожи с применением нескольких изображающих систем
Authors: Кудрин К.Г. , Римская Е.Н. , Аполлонова И.А. , Николаев А.П. , Черномырдин Н.В. , Святославов Д.С. , Давыдов Д.В. , Решетов И.В.
Published: April 2020

A complex approach to the early diagnosis of skin melanoma has been proposed. The approach involves a step-by-step examination of pigment tumors using several imaging systems. The features of morphometry of clinical images of pigmented skin neoplasms, features of imaging systems, the main stages of automated image processing and pattern recognition in the melanoma diagnosis has been considered. The metrological features of the proposed approach has been shown: the measurement errors of the clinical parameters of skin neoplasms by the proposed methods do not exceed the allowable errors. The approbation of the offered approach has been showed that sensitivity and specificity of the used methods exceeds 90%
User Experience and Potential Health Effects of a Conversational Agent-Based Electronic Health Intervention: Protocol for an Observational Cohort Study
Authors: Hurmuz Marian Z M , Jansen-Kosterink Stephanie M , op den Akker Harm , Hermens Hermie J
Published: April 2020

Background

While the average human life expectancy has increased remarkably, the length of life with chronic conditions has also increased. To limit the occurrence of chronic conditions and comorbidities, it is important to adopt a healthy lifestyle. Within the European project “Council of Coaches,” a personalized coaching platform was developed that supports developing and maintaining a healthy lifestyle.

Objective

The primary aim of this study is to assess the user experience with and the use and potential health effects of a fully working Council of Coaches system implemented in a real-world setting among the target population, specifically older adults or adults with type 2 diabetes mellitus or chronic pain.

Methods

An observational cohort study with a pretest-posttest design will be conducted. The study population will be a dynamic cohort consisting of older adults, aged ≥55 years, as well as adults aged ≥18 years with type 2 diabetes mellitus or chronic pain. Each participant will interact in a fully automated manner with Council of Coaches for 5 to 9 weeks. The primary outcomes are user experience, use of the program, and potential effects (health-related factors). Secondary outcomes include demographics, applicability of the virtual coaches, and user interaction with the virtual coaches.

Results

Recruitment started in December 2019 and is conducted through mass mailing, snowball sampling, and advertisements in newspapers and social media. This study is expected to conclude in August 2020.

Conclusions

The results of this study will either confirm or reject the hypothesis that a group of virtual embodied conversational coaches can keep users engaged over several weeks of interaction and contribute to positive health outcomes.

Trial Registration

The Netherlands Trial Register: NL7911; https://www.trialregister.nl/trial/7911

International Registered Report Identifier (IRRID)

PRR1-10.2196/16641
Diabetes Management Experience and the State of Hypoglycemia: National Online Survey Study
Authors: Zahed Karim , Sasangohar Farzan , Mehta Ranjana , Erraguntla Madhav , Qaraqe Khalid
Published: April 2020

Background

Hypoglycemia, or low blood sugar levels, in people with diabetes can be a serious life-threatening condition, and serious outcomes can be avoided if low levels of blood sugar are proactively detected. Although technologies exist to detect the onset of hypoglycemia, they are invasive or costly or exhibit a high incidence of false alarms. Tremors are commonly reported symptoms of hypoglycemia and may be used to detect hypoglycemic events, yet their onset is not well researched or understood.

Objective

This study aimed to understand diabetic patients’ perceptions of hypoglycemic tremors, as well as their user experiences with technology to manage diabetes, and expectations from a self-management tool to ultimately inform the design of a noninvasive and cost-effective technology that detects tremors associated with hypoglycemia.

Methods

A cross-sectional internet panel survey was administered to adult patients with type 1 diabetes using the Qualtrics platform in May 2019. The questions focused on 3 main constructs: (1) perceived experiences of hypoglycemia, (2) experiences and expectations about a diabetes management device and mobile app, and (3) beliefs and attitudes regarding intention to use a diabetes management device. The analysis in this paper focuses on the first two constructs. Nonparametric tests were used to analyze the Likert scale data, with a Mann-Whitney U test, Kruskal-Wallis test, and Games-Howell post hoc test as applicable, for subgroup comparisons to highlight differences in perceived frequency, severity, and noticeability of hypoglycemic tremors across age, gender, years living with diabetes, and physical activity.

Results

Data from 212 respondents (129 [60.8%] females) revealed statistically significant differences in perceived noticeability of tremors by gender, whereby males noticed their tremors more (P<.001), and age, with the older population reporting lower noticeability than the young and middle age groups (P<.001). Individuals living longer with diabetes noticed their tremors significantly less than those with diabetes for ≤1 year but not in terms of frequency or severity. Additionally, the majority of our participants (150/212, 70.7%) reported experience with diabetes-monitoring devices.

Conclusions

Our findings support the need for cost-efficient and noninvasive continuous monitoring technologies. Although hypoglycemic tremors were perceived to occur frequently, such tremors were not found to be severe compared with other symptoms such as sweating, which was the highest rated symptom in our study. Using a combination of tremor and galvanic skin response sensors may show promise in detecting the onset of hypoglycemic events.
Clinical Trials in Social Media: Content Analysis of YouTube Videos in Arabic Language (Preprint)
Authors: Tabba' Amal , Kateb Linda , Al-Hussaini Maysa
Published: April 2020

BACKGROUND

Clinical trials are fundamental to the advancement of cancer care; nonetheless, recruitment remains inadequate. A frequently reported barrier to participation is the lack of awareness and knowledge about clinical trials. Research showed that the internet is being used now as a primary source for information on clinical trials.

OBJECTIVE

We aim in this study to review available videos uploaded on the YouTube, one of the most-visited websites worldwide, about clinical trials in Arabic language and evaluate the comprehensiveness of its content.

METHODS

YouTube videos were searched using the keywords “clinical trials” and “clinical studies” in Arabic language. Only videos targeting the public were included in the study. Videos targeting medical students/ healthcare professionals, discussing country-specific laws, longer than 30 minutes, or found irrelevant upon viewing were excluded from the analysis.

RESULTS

Seven videos about clinical trials were included in the final analysis. Only 1 video was related specifically to cancer clinical trials (14.3%). The mean length of videos was 6:43 minutes (range: 1:37-16:53 minutes) with a total number of views of 11,207 (mean 1,601.0, SD ±2,054.6). More than half of the videos (n=4, 57.1%) were created by TV/ Internet Channels and were neutral in tone. Most common presentation style and country of origin were vlog and Saudi Arabia, receptivity (n=3, 42.9% for both).

For video-related content, the most frequently mentioned variables were the purpose of clinical trials to test new drug/devices in humans (n=6, 85.7%), animal testing conducted before clinical trials, clinical trials are conducted on several phases, phase I clinical trials and the aim of phase I studies is to assess safety (n=5, 71.5%; for all items). These were followed by mention of phase II and phase III in general (n=4, 57.1%; for both items).

CONCLUSIONS

This study identified a clear scarcity of YouTube videos about clinical trials in the Arabic language, as well as, potential gaps in the comprehensiveness of the content presented. Viewers’ engagement presented in number of views, likes and dislikes seems to be very low. Stakeholders need to pay more attention to the use of social media in prompting clinical trials and providing comprehensive and reliable sources of information to the public.

CLINICALTRIAL

None
The Use of Digital Health in the Detection and Management of COVID-19 (Preprint)
Authors: Alwashmi Meshari
Published: April 2020

UNSTRUCTURED

Digital health is uniquely positioned to transform the way we detect and manage infectious diseases. This viewpoint explores the potential of implementing digital technologies that can be used at different stages of the COVID-19 outbreak, including data-driven disease surveillance, screening, triage, diagnosis, and monitoring. Methods that could potentially reduce the exposure of healthcare providers to the virus are also discussed.
Updates in Diagnosis and Management of Preeclampsia in Women with CKD
Authors: Wiles Kate , Chappell Lucy C. , Lightstone Liz , Bramham Kate
Published: April 2020

It is estimated that women with CKD are ten times more likely to develop preeclampsia than women without CKD, with preeclampsia affecting up to 40% of pregnancies in women with CKD. However, the shared phenotype of hypertension, proteinuria, and impaired excretory kidney function complicates the diagnosis of superimposed preeclampsia in women with CKD who have hypertension and/or proteinuria that predates pregnancy. This article outlines the diagnoses of preeclampsia and superimposed preeclampsia. It discusses the pathogenesis of preeclampsia, including abnormal placentation and angiogenic dysfunction. The clinical use of angiogenic markers as diagnostic adjuncts for women with suspected preeclampsia is described, and the limited data on the use of these markers in women with CKD are presented. The role of kidney biopsy in pregnancy is examined. The management of preeclampsia is outlined, including important advances and controversies in aspirin prophylaxis, BP treatment targets, and the timing of delivery.
Seguridad alimentaria y sus desequilibrios regionales en México
Authors: Torres Felipe , Rojas Martínez Agustín
Published: April 2020

El presente trabajo busca analizar las dimensiones regionales de la seguridad alimentaria y sus desequilibrios territoriales en México. Mediante la aplicación del método de componentes principales, se elaboró un índice a nivel municipal y regional que, además de combinar información de variables diversas que se concentran en una medida única, sintetiza numéricamente tres de las cuatro dimensiones con que se mide la problemática: acceso, disponibilidad y utilización biológica. A la par se empleó el método de estratificación Dalenius-Hodges para establecer rangos de seguridad alimentaria a distintas escalas regionales. Los resultados muestran que las desigualdades socioeconómicas y territoriales, provocadas por los modelos de desarrollo aplicados en el pasado, afectan la seguridad alimentaria de la población en sus espacios regionales.
The Temporal Structure of Patience
Authors: Kelly Michael R.
Published: April 2020

Abstract

This paper presents Anthony Steinbock's broad theory of moral emotions and specifically the distinction he draws between the temporal orientation and the temporal meaning of emotions. The latter distinction is used in order to provide phenomenological descriptions of, and distinctions between, patience and impatience. The paper takes leading clues from Steinbock’s work in an effort to “do” phenomenology in a way that clarifies these specific natural attitude intentionalities.
From Phenomenological Self-Givenness to the Notion of Spiritual Freedom
Authors: Hennigfeld Iris
Published: April 2020

In my paper, I want to focus not only on the notions of givenness and evidence in Husserl’s phenomenology, but also on phenomenological work “after” Husserl. I will elaborate on how these phenomenological key ideas can methodologically be made fruitful, especially for an investigation into religious phenomena. After giving an outline of Husserl’s notions of (self-)givenness, evidence, and original intuition (I), I want to portray key elements of Steinbock’s discovery of a generative dimension in Husserl’s phenomenology and show how this approach correlates to the field of religious experiences (II). Subsequently, I want to focus on Steinbock’s book Phenomenology of Mysticism: The Verticality of Religious Experience (2007), and elucidate how for Steinbock different historical examples of mystical experiences can serve as leading clues for the revelation of the essential, eidetic structures of “vertical experiences”—or, phenomenologically speaking, the eidos of religious experience, which turns out to be “epiphany” (III). The expression “verticality,” as opposed to “horizontality,” denotes the existential and dynamic dimension of experiences which are oriented toward a new height (religiously or morally) “beyond” ourselves.
Augmented reality: Analisis Pengembangan Media Pembelajaran Kimia untuk Meningkatkan Keterampilan 4C Mahasiswa
Authors: Elisa Edi , Wiratmaja IGede
Published: April 2020

[ Augmented reality: Analysis of Development the Chemical Instructional Media to Improve 4c Skill of Students ]

Penelitian ini bertujuan untuk mengetahui proses pengembangan media pembelajaran kimia berbasis augmented reality dengan harapan dapat digunakan untuk meningkat keterampilan 4C mahasiswa. Jenis penelitian termasuk kedalam penelitian dan pengembangan (R&D) dengan menggunakan model pengembangan ADDIE yang terdiri dari lima tahap. Pada artikel ini pembahasan akan difokuskan pada tahap analisis. Fokus kegiatan pada tahap analisis yaitu menganalisa keterampilan yang dibutuhkan di abad 21, menganalisa proses pembelajaran, menganalisa berbagai kemungkinan media pembelajaran yang dapat digunakan dan mengambil suatu keputusan. Instrumen yang digunakan pada tahap ini yaitu lembar observasi, tes essay, angket dan daftar pertanyaan wawancara. Subjek uji coba adalah program studi Pendidikan Teknik Mesin Fakultas Teknik dan Kejuruan Universitas Pendidikan Ganesha, sampel merupakan mahasiswa yang mengontrak matakuliah kimia teknik. Berdasarkan hasil analisis kebutuhan dan analisis awal dan akhir, maka ditetapkan media yang paling sesuai dan akan dikembangkan yaitu augmented reality yang didukung dengan seperangkat kartu pembelajaran. Produk yang dihasilkan harus didesain untuk dapat meningkatkan keterampilan 4C mahasiswa.
NAAS Reports
Authors: Laitinen Tuomo , Mikkelsen Robert
Published: April 2020

Nordic Association for American Studies (NAAS)