bluuebunny/crossref_metadata_2025 huggingface dataset:
The Design and Validation of a Compassion Fatigue Scale in Peruvian Nurses
Authors: Carranza Esteban Renzo Felipe , Mamani-Benito Oscar , Turpo Chaparro Josué E. , Chávez Sosa Janett V. , Lingan Susana K.
Published: June 2023

The objective of this study was to design and validate the Compassion Fatigue Scale (EFat-Com) in Peruvian nurses. Methods: A 13-item scale was designed using qualitative procedures and expert judgment. This version was administered to 201 nursing professionals using an electronic form along with two other measures: the Patient Health Questionnarie-2 and the Satisfaction with Life Scale. Results: Exploratory factor analysis supported the existence of two factors with factor loadings > 0.54. Confirmatory factor analysis of the two-factor model yielded satisfactory fit indices after the elimination of two items. Regarding concurrent validity, a positive relationship was obtained between the EFat-Com and the measure of depression; however, no correlation was found with the measure of life satisfaction. The internal consistency was 0.807 for the total scale, 0.79 for Factor 1, and 0.83 for Factor 2. Conclusions: The EFat-Com showed adequate psychometric properties with respect to content-based validity evidence, internal structure, and reliability. Therefore, the instrument can be used in research and professional settings. However, it is essential to continue studying the validity evidence in other contexts.
A Study on the Health-Related Issues and Behavior of Vietnamese Migrants Living in Japan: Developing Risk Communication in the Tuberculosis Response
Authors: Lee Sangnim , Nguyen Nhan Huu Thanh , Takaoka Shori , Do An Dang , Shirayama Yoshihisa , Nguyen Quy Pham , Akutsu Yusuke , Takasaki Jin , Ohkado Akihiro
Published: June 2023

Ensuring a healthy lifestyle for the increasing number of Vietnamese migrants living in Japan is a key public health issue, including infectious disease responses such as tuberculosis (TB). To develop risk communication in relation to the TB response, this study aimed to explore the health issues and health-related behaviors of Vietnamese migrants living in Japan using a mixed method. A survey was conducted on Vietnam-born migrants, aged 18 years and over, in Tokyo. The survey consisted of questions on the following components: (1) demographics; (2) health-related issues and behavior; and (3) health-seeking behavior, information, and communication. A total 165 participants participated in the survey. The majority of the participants were young adults. 13% of the participants responded that they were concerned about their health. Moreover, 22% and 7% of the participants reported weight loss and respiratory symptoms, respectively. 44% of the participants answered they had no one to consult about their health in Japan when they needed it, and 58% answered they had no awareness of any Vietnamese-language health consultation services. Logistic regression analysis revealed that people who contact family members living in Vietnam or overseas using social networking services (SNSs) when they needed to consult someone about their health (adjusted odds ratio (AOR) = 6.09, 95% confidence interval (CI) 1.52–24.43) were more likely to present with one or more of the typical TB symptoms, compared to those who did not consult someone in this manner. Current smokers (OR = 3.08, 95% CI 1.15–8.23) were more likely to have health problems compared to non-smokers. The key informant interviews revealed that individual factors, the health system, and socio-environmental factors may hinder Vietnamese migrants’ health-seeking and health-information-seeking behaviors in Japan. TB risk communication approaches for migrants need to be developed considering their health-related behaviors while addressing their health needs.
PMGCN: Progressive Multi-Graph Convolutional Network for Traffic Forecasting
Authors: Li Zhenxin , Han Yong , Xu Zhenyu , Zhang Zhihao , Sun Zhixian , Chen Ge
Published: June 2023

Traffic forecasting has always been an important part of intelligent transportation systems. At present, spatiotemporal graph neural networks are widely used to capture spatiotemporal dependencies. However, most spatiotemporal graph neural networks use a single predefined matrix or a single self-generated matrix. It is difficult to obtain deeper spatial information by only relying on a single adjacency matrix. In this paper, we present a progressive multi-graph convolutional network (PMGCN), which includes spatiotemporal attention, multi-graph convolution, and multi-scale convolution modules. Specifically, we use a new spatiotemporal attention multi-graph convolution that can extract extensive and comprehensive dynamic spatial dependence between nodes, in which multiple graph convolutions adopt progressive connections and spatiotemporal attention dynamically adjusts each item of the Chebyshev polynomial in graph convolutions. In addition, multi-scale time convolution was added to obtain an extensive and comprehensive dynamic time dependence from multiple receptive field features. We used real datasets to predict traffic speed and traffic flow, and the results were compared with a variety of typical prediction models. PMGCN has the smallest Mean Absolute Error (MAE), Root Mean Squared Error (RMSE), and Mean Absolute Percentage Error (MAPE) results under different horizons (H = 15 min, 30 min, 60 min), which shows the superiority of the proposed model.
Artificial Intelligence and Agility-Based Model for Successful Project Implementation and Company Competitiveness
Authors: Tominc Polona , Oreški Dijana , Rožman Maja
Published: June 2023

The purpose of the paper is to present a model of factors affecting the successful project implementation by introducing agility and artificial intelligence to increase the company’s competitiveness. In the model, the multidimensional constructs describing the implementation of an agile work environment and artificial intelligence technologies and tools were developed. These multidimensional constructs are agile work environment, agile leadership, agile team skills and capabilities, improving the work of the leader in the project, adopting AI technologies in the project, and using AI solutions in a project. Their impact on successful project implementation and on the company competitiveness was tested. The fundamental reason for conducting this research and developing the model is to enhance the understanding of factors that contribute to the successful implementation of projects and to increase a company’s competitiveness. Our developed model encompasses multidimensional constructs that describe the agile work environment and the utilization of AI technologies. By examining the impact of these constructs on both successful project implementation and company competitiveness, we aimed to establish a comprehensive framework that captures the relationship between agility, AI, and successful project implementation. This model serves as a valuable tool for companies seeking to improve their project implementation processes and gain a competitive edge in the market. The research was based on a sample of 473 managers/owners in medium-sized and large companies. Structural equation modeling was used to test the hypotheses. In today’s turbulent environment, the results will help develop guidelines for a successful combination of agile business practices and artificial intelligence to achieve successful project implementation, increasing a company’s competitiveness.
Fostering Trustworthiness of Federated Learning Ecosystem through Realistic Scenarios
Authors: Psaltis Athanasios , Zafeirouli Kassiani , Leškovský Peter , Bourou Stavroula , Vásquez-Correa Juan Camilo , García-Pablos Aitor , Cerezo Sánchez Santiago , Dimou Anastasios , Patrikakis Charalampos Z. , Daras Petros
Published: June 2023

The present study thoroughly evaluates the most common blocking challenges faced by the federated learning (FL) ecosystem and analyzes existing state-of-the-art solutions. A system adaptation pipeline is designed to enable the integration of different AI-based tools in the FL system, while FL training is conducted under realistic conditions using a distributed hardware infrastructure. The suggested pipeline and FL system’s robustness are tested against challenges related to tool deployment, data heterogeneity, and privacy attacks for multiple tasks and data types. A representative set of AI-based tools and related datasets have been selected to cover several validation cases and distributed to each edge device to closely reflect real-world scenarios. The study presents significant outcomes of the experiments and analyzes the models’ performance under different realistic FL conditions, while highlighting potential limitations and issues that occurred during the FL process.
The Smart Governance Framework and Enterprise System’s Capability for Improving Bio-Business Licensing Services
Authors: Maulana Muhammad Mahreza , Suroso Arif Imam , Nurhadryani Yani , Seminar Kudang Boro
Published: June 2023

One way to improve Indonesia’s ranking in terms of ease of conducting business is by taking a closer look at the business licensing process. This study aims to carry out an assessment using a smart governance framework and recommendation capabilities from the Enterprise System (ES). As a result, the recommendations for improvement with the expected priority are generated. The stages of this research are observing the process of making bio-business permits, followed by interviews related to several Enterprise Architecture (EA) capabilities, and providing recommendations based on the results of the maturity level of IT governance. These recommendations are then mapped into an impact—effort matrix for program prioritization. The recommendations for bio-business licenses can also be used to improve the process for other business licenses. Implementation of the EA framework has been proven to align technology, organization, and processes so that it can support continuous improvement processes.
Attraction of Frankliniella occidentalis Females towards the Aggregation Pheromone Neryl (S)-2-Methylbutanoate and Kairomones in a Y-Olfactometer
Authors: Chappuis Charles J. F. , Cléroux Marilyn , Descombes Corentin , Barth Yannick , Lefort François
Published: June 2023

An understanding of insect olfaction allows for more specific alternative methods of pest control. We evaluated the responses of the western flower thrips (WFT, Frankliniella occidentalis) in a Y-olfactometer to estimate gas-phase concentrations of the aggregation pheromone neryl (S)-2-methylbutanoate and known kairomones such as methyl isonicotinate, (S)-(-)-verbenone, and p-anisaldehyde. The gas-phase concentrations of these compounds were obtained from the release rates measured in dynamic headspace cells. The compounds were collected from the headspace using dried solid-phase extraction (SPE) cartridges and analyzed with a triple quadrupole GC-MS/MS. We observed that the aggregation pheromone significantly attracted WFT females at doses of 10 and 100 µg, whereas methyl isonicotinate and p-anisaldehyde significantly attracted WFT females at the highest dose. Verbenone did not produce any significant results. A completely different picture was obtained when the gas-phase concentrations were considered. The minimal gas-phase concentrations of the pheromone required to attract WFT females was 0.027 ng/mL, at least 100 times lower than that of the other two compounds. The relevance and implications of our results are discussed in light of the insect’s biology and pest management methods.
Novel lncRNA LNC_000113 Drives the Activation of Pulmonary Adventitial Fibroblasts through Modulating PTEN/Akt/FoxO1 Pathway
Authors: Luo Hui , Zhao Lin , Ou Ziwei , Li Tangzhiming , Liu Yanghong , Yu Zaixin
Published: June 2023

The activation of pulmonary adventitial fibroblasts (PAFs) is one of the key components of pulmonary arterial remodelling in pulmonary arterial hypertension (PAH). Emerging evidence indicates that lncRNAs may play fibrotic roles in a range of diseases. In this present study, we identified a novel lncRNA, LNC_000113, in pulmonary adventitial fibroblasts (PAFs) and characterised its role in the Galectin-3-induced activation of PAFs in rats. Galectin-3 led to elevated expression of lncRNA LNC_000113 in PAFs. The expression of this lncRNA was primarily PAF enriched. A progressive increase in lncRNA LNC_000113 expression was observed in rats with monocrotaline (MCT)-induced PAH rats. Knockdown of lncRNA LNC_000113 cancelled the Galectin-3′s fibroproliferative effect on PAFs and prevented the transition of fibroblasts to myofibroblasts. The loss-of-function study demonstrated that lncRNA LNC_000113 activated PAFs through the PTEN/Akt/FoxO1 pathway. These results propose lncRNA LNC_000113 drives the activation of PAFs and promotes fibroblast phenotypic alterations.
Integrating Early-Stage Drug Development with Clinical Networks; Challenges and Opportunities: The City of Hope Developing Experience
Authors: Villalona-Calero Miguel A. , Malhotra Jyoti , Chung Vincent , Xing Yan , Gray Stacy W. , Hampel Heather , Gruber Stephen , McDonnell Kevin
Published: June 2023

Recent data suggest that patients with advanced cancer who participate in biomarker/genomically informed early-stage clinical trials experience clinical benefit. While most early-stage clinical trials are conducted in major academic centers, the majority of cancer patients in the United States are treated in community practices. Here, we describe ongoing efforts at the City of Hope Cancer Center to integrate our network community oncology clinical practices into our academic, centralized biomarker/genomic-driven, early-stage clinical trial program to build an understanding of the approaches that provide the benefits of early-stage clinical trial participation to community patients. Our efforts include three key initiatives: the development of a virtual “Refractory Disease” phase 1 trial matching televideo clinic, the construction of infrastructure to support the expansion of phase 1 clinical trials to a distant regional clinical satellite hub, and the implementation of an enterprise-wide precision medicine, germline, and somatic testing program. Our work at City of Hope may serve as an example to facilitate similar efforts at other institutions.
Potentially Inappropriate Medications Use among Older Adults with Dyslipidaemia
Authors: Alwhaibi Monira , Alkofide Hadeel
Published: June 2023

Background: Since older patients with dyslipidemia frequently receive many prescriptions, medication errors are typical and expected in this population. This risk has increased by using potentially inappropriate medications. The 2019 Beers criteria were used in this study to investigate potentially inappropriate medication use among older individuals with dyslipidemia. Methods: A cross-sectional retrospective analysis used data from electronic medical records from an ambulatory-care environment. Patients with dyslipidemia who were older adults (>65 years old) were included. To describe and find potential determinants of potentially inappropriate medication usage, descriptive statistics and logistic regression were employed. Results: This study included 2209 older adults (age ≥ 65) with dyslipidemia. The mean age was 72.1 ± 6.0 years, and the majority of the study sample had hypertension (83.7%) and diabetes (61.7%), and around 80.0% were using polypharmacy. The prevalence of potentially inappropriate medications to be avoided among older adults with dyslipidemia was 48.6%. A high risk of potentially inappropriate medication usage was found in older patients with dyslipidemia who had polypharmacy and comorbid diabetes, ischemic heart disease, and anxiety. Conclusions: This study showed that the number of medications prescribed and the presence of concurrent chronic health conditions are important indicators of the risk of potentially inappropriate medications in ambulatory older patients with dyslipidemia.
Quantitative Phase Imaging Using Digital Holographic Microscopy to Assess the Degree of Intestinal Inflammation in Patients with Ulcerative Colitis
Authors: Bokemeyer Arne , Buskermolen Joost , Ketelhut Steffi , Tepasse Phil-Robin , Vollenberg Richard , Trebicka Jonel , Schmidt Hartmut H. , Vieth Michael , Bettenworth Dominik , Kemper Björn
Published: June 2023

Ulcerative colitis (UC) is characterized by chronic inflammation of the colorectum. Histological remission has emerged as a potential future treatment goal; however, the histopathological assessment of intestinal inflammation in UC remains challenging with a multitude of available scoring systems and the need for a pathologist with expertise in inflammatory bowel disease (IBD). In previous studies, quantitative phase imaging (QPI) including digital holographic microscopy (DHM) was successfully applied as an objective method for stain-free quantification of the degree of inflammation in tissue sections. Here, we evaluated the application of DHM for the quantitative assessment of histopathological inflammation in patients with UC. In our study, endoscopically obtained colonic and rectal mucosal biopsy samples from 21 patients with UC were analyzed by capturing DHM-based QPI images that were subsequently evaluated using the subepithelial refractive index (RI). The retrieved RI data were correlated with established histological scoring systems including the Nancy index (NI) as well as with endoscopic and clinical findings. As a primary endpoint, we found a significant correlation between the DHM-based retrieved RI and the NI (R2 = 0.251, p < 0.001). Furthermore, RI values correlated with the Mayo endoscopic subscore (MES; R2 = 0.176, p < 0.001). An area under the receiver operating characteristics (ROC) curve of 0.820 confirms the subepithelial RI as a reliable parameter to distinguish biopsies with histologically active UC from biopsies without evidence of active disease as determined by conventional histopathological examination. An RI higher than 1.3488 was found to be the most sensitive and specific cut-off value to identify histologically active UC (sensitivity of 84% and specificity of 72%). In conclusion, our data demonstrate DHM to be a reliable tool for the quantitative assessment of mucosal inflammation in patients with UC.
Body Image and Emotional Status in Patients with Acquired Brain Injury
Authors: Lo Buono Viviana , Corallo Francesco , Bonanno Lilla , Quartarone Angelo , De Cola Maria Cristina
Published: June 2023

Emotional experiences can lead to a real or distorted self-representation. After brain damage, altered self-perception of one’s own body image is frequent. This study evaluates the relationship of mood disorders and lesion sites on body image in a cohort of ABI patients. A total of 46 patients (26 men, 20 women) without severe physical impairments were found eligible for this study. Patients underwent Beck’s Depression Inventory and the Hamilton Rating Scale for Anxiety to assess mood disorders, whereas the Body Image Scale and Human Figure Drawing were used to evaluate body dissatisfaction and implicit body image. The Montreal Cognitive Assessment was used to assess patients’ cognitive condition. We found a moderate correlation between depression and body image (r = 0.48), as well as between anxiety and body image (r = 0.52), and the regression model also reported the right lesion site as a predictive variable for body image score. In addition, the regression model built by Human Figure Drawing scores showed anxiety, cognitive functioning, and a marital status of single to be significant predictors. The study confirmed that participants with acquired brain injury have deficits in body representation associated with mood disorders, regardless of the side of the lesions. A neuropsychological intervention could be useful for these patients to improve their cognitive performance and learn to manage emotional dysfunction in order to increase their self-perception of body image and improve their quality of life.
Post-Traumatic Stress Disorder among Polish Healthcare Staff in the Era of the COVID-19 Pandemic
Authors: Kobelski Grzegorz , Naylor Katarzyna , Ślusarz Robert , Wysokiński Mariusz
Published: June 2023

Introduction: The COVID-19 pandemic has brought many adverse phenomena, particularly in the area of health for both individuals and society as a whole. Healthcare staff also suffered dire consequences. Aim: The aim of this study was to assess whether the COVID-19 pandemic increased the risk of post-traumatic stress disorder among healthcare professionals in Poland. Material and method: The survey was conducted between 4 April 2022 and 4 May 2022. The study applied the Computer Assisted Web Interview (CAWI) technique using the standardised Peritraumatic Distress Inventory (PDI) questionnaire. Results: The average score obtained by the respondents on the PDI was 21.24 ± 8.97. There was a statistically significant difference between the average PDI score obtained based on the gender of the subject (Z = 3.873, p = 0.0001.) The score obtained amongst nurses was statistically significantly higher compared to the paramedic group (H = 6.998, p = 0.030). There was no statistically significant difference between the average PDI score obtained based on the age of the participants (F = 1.282, p = 0.281), nor with their length of service (F = 0.934, p = 0.424). A total of 82.44% of the respondents received 14 PDI points, the cut-off point indicating the risk of PTSD that was adopted in the study. It was concluded that 6.12% of respondents did not require intervention (<7 PDI score); 74.28% of respondents needed further follow-up for PTSD and a reassessment of the PDI approximately 6 weeks after the initial testing; and 19.59% required coverage for PTSD prevention and mitigation (>28 PDI score). Conclusions: The study has shown a high risk of post-traumatic stress disorder among healthcare professionals in Poland. This risk is related to the gender of the respondents, with an indication of a higher risk of PTSD among women. The results have also shown a correlation between increased risk of post-traumatic stress disorder and occupation, with nurses being the most affected group. In contrast, no association has been found in terms of age and length of service for an increase in the risk of PTSD, following exposure to trauma in relation to healthcare services during the COVID-19 pandemic.
Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box
Authors: Turesheva Akbayan , Aimagambetova Gulzhanat , Ukybassova Talshyn , Marat Aizada , Kanabekova Perizat , Kaldygulova Lyazzat , Amanzholkyzy Ainur , Ryzhkova Svetlana , Nogay Anastassiya , Khamidullina Zaituna , Ilmaliyeva Aktoty , Almawi Wassim Y. , Atageldiyeva Kuralay
Published: June 2023

Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. Inconsistency in definitions involves not only the number of spontaneous abortions (two or three) that are accepted for recurrent pregnancy loss but the types of pregnancy and gestational age at miscarriage. Due to the heterogeneity of definitions and criteria applied by international guidelines for recurrent pregnancy loss, the true incidence of recurrent miscarriage, which is reported to range from 1% to 5%, is difficult to estimate. Moreover, the exact etiology of recurrent pregnancy loss remains questionable; thus, it is considered a polyetiological and multifactorial condition with many modifiable and non-modifiable factors involved. Even after thoroughly evaluating recurrent pregnancy loss etiology and risk factors, up to 75% of cases remain unexplained. This review aimed to summarize and critically analyze accumulated knowledge on the etiology, risk factors, relevant diagnostic options, and management approach to recurrent pregnancy loss. The relevance of various factors and their proposed roles in recurrent pregnancy loss pathogenesis remains a matter of discussion. The diagnostic approach and the management largely depend on the etiology and risk factors taken into consideration by a healthcare professional as a cause of recurrent miscarriage for a particular woman or couple. Underestimation of social and health consequences of recurrent pregnancy loss leads to compromised reproductive health and psychological well-being of women after miscarriage. Studies on etiology and risk factors for recurrent pregnancy loss, especially idiopathic, should be continued. The existing international guidelines require updates to assist clinical practice.
Intensive Therapy of the Lower Limbs and the Trunk in Children with Bilateral Spastic Cerebral Palsy: Comparing a Qualitative Functional and a Functional Approach
Authors: van Tittelboom Vanessa , Heyrman Lieve , De Cat Josse , Algoet Patrick , Peeters Nicky , Alemdaroğlu-Gürbüz Ipek , Plasschaert Frank , Van Herpe Katrin , Molenaers Guy , De Bruyn Nele , Deschepper Ellen , Desloovere Kaat , Calders Patrick , Feys Hilde , Van den Broeck Christine
Published: June 2023

Few studies have examined the effect of intensive therapy on gross motor function and trunk control in children with cerebral palsy (CP). This study evaluated the effects of an intensive burst of therapy on the lower limbs and trunk by comparing qualitative functional and functional approaches. This study was designed as a quasi-randomized, controlled, and evaluator-blinded trial. Thirty-six children with bilateral spastic CP (mean age = 8 y 9 mo; Gross Motor Function Classification II and III) were randomized into functional (n = 12) and qualitative functional (n = 24) groups. The main outcome measures were the Gross Motor Function Measure (GMFM), the Quality Function Measure (QFM), and the Trunk Control Measurement Scale (TCMS). The results revealed significant time-by-approach interaction effects for all QFM attributes and the GMFM’s standing dimension and total score. Post hoc tests showed immediate post-intervention gains with the qualitative functional approach for all QFM attributes, the GMFM’s standing and walking/running/jumping dimension and total score, and the total TCMS score. The qualitative functional approach shows promising results with improvements in movement quality and gross motor function.
Comparative Analysis of Neonatal Effects in Pregnant Women with Cardiovascular Risk versus Low-Risk Pregnant Women
Authors: Abu-Awwad Simona-Alina , Craina Marius , Gluhovschi Adrian , Boscu Lioara , Bernad Elena , Iurciuc Mircea , Abu-Awwad Ahmed , Iurciuc Stela , Tudoran Cristina , Bernad Robert , Maghiari Anca Laura
Published: June 2023

Background: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Pregnancy imposes unique physiological changes on a woman’s cardiovascular system. Materials and Methods: A cohort of 68 participants, comprising 30 pregnant women with cardiovascular risk and 38 without cardiovascular risk, was recruited for this study. These participants were prospectively followed during their pregnancies from 2020 to 2022 at the Obstetrics and Gynecology Department of the “Pius Brînzeu” Emergency County Clinical Hospital in Timişoara, Romania. All women included in this study underwent cesarean section deliveries at the same medical facility. Data regarding the gestational weeks at delivery, birth weight, and Apgar scores assessed by neonatologists were collected for each participant. Statistical analyses were performed to compare the neonatal effects between the two groups. Results: The results of this study revealed significant differences between the groups in terms of Apgar scores (p = 0.0055), gestational weeks (p = 0.0471), and baby birth weight (p = 0.0392). Conclusion: The findings underscore the importance of considering maternal cardiovascular health as a potential determinant of neonatal outcomes. Further research is needed to elucidate the underlying mechanisms and develop strategies for optimizing neonatal outcomes in high-risk pregnancies.
Hearing Outcome and Predictors after Implanting Bone Conduction or Middle Ear Implants in Ears with Refractory Otitis Media
Authors: Kurihara Sho , Nakamura Takeshi , Kubuki Kan , Koga Hiroyuki , Goto Takashi , Shimoara Shouken , Ganaha Akira , Yamada Yuusuke , Takahashi Kuniyuki , Tono Tetsuya
Published: June 2023

Bone conduction implants (BCIs) and middle ear implants (MEIs) are promising options for individuals with persistent chronic inflammation of the middle or outer ear. However, the structure of the middle ear is often altered in patients who undergo mastoidectomy or posterior wall removal for refractory otitis media, leaving uncertainty regarding the efficacy of hearing devices. Only a few studies have examined auditory outcomes based on the etiology of hearing impairment. We investigated hearing outcomes, including speech audiometry, in patients who underwent implantation after surgery for refractory otitis media. Our findings indicated that patients who received BCIs or MEIs achieved favorable hearing outcomes. Furthermore, a correlation was observed between the preoperative bone-conduction threshold at 1 kHz in the better ear and the sound-field threshold at 1 kHz with BCIs, whereas no correlation was observed between the preoperative bone-conduction threshold and the sound-field threshold with MEIs. This study highlights the positive impact of BCIs and MEIs in patients who undergo implantation after surgery for refractory otitis media. Additionally, our study identified parameters that predict postoperative efficacy.
Laryngeal Penetration and Risk of Aspiration Pneumonia in Children with Dysphagia—A Systematic Review
Authors: Imdad Aamer , Wang Alice G. , Adlakha Vaishali , Crespo Natalie M. , Merrow Jill , Smith Abigail , Tsistinas Olivia , Tanner-Smith Emily , Rosen Rachel
Published: June 2023

This study was a systematic review and meta-analysis that assessed the risk of aspiration pneumonia in children with laryngeal penetration or tracheal aspiration via a video-fluoroscopic study (VFSS) and compared the results to those for children with neither condition. Systematic searches were conducted using databases, including PubMed, Cochrane Library, and Web of Science. Meta-analysis was used to obtain summary odds ratios (OR) and 95% confidence intervals (CI). The overall quality of evidence was assessed using the grading of recommendations, assessment, development, and evaluation (GRADE) criteria. In total, 13 studies were conducted with 3159 participants. Combined results from six studies showed that laryngeal penetration on VFSS may be associated with aspiration pneumonia compared to no laryngeal penetration; however, the summary estimate was imprecise and included the possibility of no association (OR 1.44, 95% CI 0.94, 2.19, evidence certainty: low). Data from seven studies showed that tracheal aspiration might be associated with aspiration pneumonia compared to no tracheal aspiration (OR 2.72, 95% CI 1.86, 3.98, evidence certainty: moderate). The association between aspiration pneumonia and laryngeal penetration through VFSS seems to be weaker than that for tracheal aspiration. Prospective cohort studies with clear definitions of laryngeal penetration and that measure clinical and patient reported outcomes are needed to further define the association between laryngeal penetration and aspiration pneumonia.
Reliability of a Smooth Pursuit Eye-Tracking System (EyeGuide Focus) in Healthy Adolescents and Adults
Authors: Pearce Alan J. , Daly Ed , Ryan Lisa , King Doug
Published: June 2023

Mild traumatic brain injury (mTBI) is the most common brain injury, seen in sports, fall, vehicle, or workplace injuries. Concussion is the most common type of mTBI. Assessment of impairments from concussion is evolving, with oculomotor testing suggested as a key component in a multimodality diagnostic protocol. The aim of this study was to evaluate the reliability of one eye-tracking system, the EyeGuide Focus. A group of 75 healthy adolescent and adult participants (adolescents: n = 28; female = 11, male = 17, mean age 16.5 ± 1.4 years; adults n = 47; female = 22; male = 25, mean age 26.7 ± 7.0 years) completed three repetitions of the EyeGuide Focus within one session. Intraclass correlation coefficient (ICC) analysis showed the EyeGuide Focus had overall good reliability (ICC 0.79, 95%CI: 0.70, 0.86). However, a familiarization effect showing improvements in subsequent trials 2 (9.7%) and 3 (8.1%) was noticeable in both cohorts (p < 0.001) with adolescent participants showing greater familiarization effects than adults (21.7% vs. 13.1%). No differences were observed between sexes (p = 0.69). Overall, this is the first study to address the concern regarding a lack of published reliability studies for the EyeGuide Focus. Results showed good reliability, suggesting that oculomotor pursuits should be part of a multimodality assessment protocol, but the observation of familiarization effects suggests that smooth-pursuit testing using this device has the potential to provide a biologically-based interpretation of the maturation of the oculomotor system, as well as its relationship to multiple brain regions in both health and injury.
Bodybuilding Coaching Strategies Meet Evidence-Based Recommendations: A Qualitative Approach
Authors: Rukstela Alexa , Lafontant Kworweinski , Helms Eric , Escalante Guillermo , Phillips Kara , Campbell Bill I.
Published: June 2023

Bodybuilding is a sport where coaches commonly recommend a variety of nutrition and exercise protocols, supplements, and, sometimes, performance-enhancing drugs (PEDs). The present study sought to gain an understanding of the common decisions and rationales employed by bodybuilding coaches. Focusing on coaches of the more muscular divisions in the National Physique Committee/IFBB Professional League federations (men’s classic physique, men’s bodybuilding, women’s physique, women’s bodybuilding) for both natural and enhanced athletes, coaches were recruited via word of mouth and social media, and 33 responded to an anonymous online survey. Survey responses indicated that participant coaches recommend three-to-seven meals per day and no less than 2 g/kg/day of protein regardless of sex, division, or PED usage. During contest preparation, participant coaches alter a natural competitor’s protein intake by −25% to +10% and an enhanced competitor’s protein intake by 0% to +25%. Regarding cardiovascular exercise protocols, approximately two-thirds of participant coaches recommend fasted cardiovascular exercise, with the common rationale of combining the exercise with thermogenic supplements while considering the athlete’s preference. Low- and moderate-intensity steady state were the most commonly recommended types of cardiovascular exercise among participant coaches; high-intensity interval training was the least popular. Creatine was ranked in the top two supplements for all surveyed categories. Regarding PEDs, testosterone, growth hormone, and methenolone were consistently ranked in the top five recommended PEDs by participant coaches. The results of this study provide insight into common themes in the decisions made by bodybuilding coaches, and highlight areas in which more research is needed to empirically support those decisions.
The Distribution of Pseudodiaptomus marinus in European and Neighbouring Waters—A Rolling Review
Authors: Uttieri Marco , Anadoli Olga , Banchi Elisa , Battuello Marco , Beşiktepe Şengül , Carotenuto Ylenia , Marques Sónia Cotrim , de Olazabal Alessandra , Di Capua Iole , Engell-Sørensen Kirsten , Goruppi Alenka , Guy-Haim Tamar , Hure Marijana , Kourkoutmani Polyxeni , Lučić Davor , Mazzocchi Maria Grazia , Michaloudi Evangelia , Morov Arseniy R. , Kurt Tuba Terbıyık , Tirelli Valentina , Vannini Jessica , Velasquez Ximena , Vidjak Olja , Wootton Marianne
Published: June 2023

Among non-native copepods, the calanoid Pseudodiaptomus marinus Sato, 1913 is the species probably spreading at the fastest pace in European and neighbouring waters since its first record in the Adriatic Sea in 2007. In this contribution, we provide an update on the distribution of P. marinus in the Mediterranean and Black Seas, along the Atlantic coasts of Europe, in the English Channel and in the southern North Sea. Starting from a previous distribution overview, we include here original and recently (2019–2023) published data to show the novel introduction of this species in different geographical areas, and its secondary spreading in already colonised regions. The picture drawn in this work confirms the strong ability of P. marinus to settle in environments characterised by extremely diverse abiotic conditions, and to take advantage of different vectors of introduction. The data presented allow speculations on realistic future introductions of P. marinus and on the potential extension of its distribution range.
New Insight into the Genus Cladocroce (Porifera, Demospongiae) Based on Morphological and Molecular Data, with the Description of Two New Species
Authors: Bertolino Marco , Cerrano Carlo , Bavestrello Giorgio , Thung Do Cong , Núñez-Pons Laura , Rispo Francesca , Efremova Jana , Mazzella Valerio , Makapedua Daisy Monica , Calcinai Barbara
Published: June 2023

During scientific expeditions in Indonesia and Vietnam, several sponge specimens belonging to the genus Cladocroce were collected. The integration of morphological and molecular analyses, incorporating species delimitation models (ABGD, ASAP, and bPTP) and phylogenetic approaches using three molecular markers (COI, 28S, and 18S–ITS1–5.8S–ITS2–28S), allowed us to discriminate three congeneric species. Two of these species (C. burapha and C. pansinii sp. nov.) were supported by morphological and molecular data, whereas a third species (C. lamellata sp. nov.) was delimited by morphological data only. We formally describe two new species, C. pansinii sp. nov. and C. lamellata sp. nov. C. aculeata is a newly recorded species for Indonesia and the first documented finding after the original description. The re-examination of the type material of C. burapha, and indirectly the molecular approach, allowed us to confirm that C. burapha lives in sympatry with C. pansinii sp. nov. in Vietnam and with C. lamellata in Indonesia. Thanks to these findings, we relocated the paratype of C. burapha to the new species described here, i.e., C. pansinii sp. nov.
A Novel Algorithm for CAD to CSG Conversion in McCAD
Authors: Harb Moataz , Leichtle Dieter , Fischer Ulrich
Published: June 2023

Modeling and simulation lie at the heart of the design process of any nuclear application. An accurate representation of the radiation environment ensures not only the feasibility of new technologies, but it also aids in operation, maintenance, and even decommissioning. With increasingly complex designs, high-fidelity models have become a necessity for design maturity. McCAD has been under development for many years at Karlsruhe Institute of Technology (KIT) to facilitate the process of generating suitable models for nuclear analyses. In this paper, an overview of the major advances in the new version of the code is presented. A novel conversion algorithm has proven to be robust in significantly reducing the processing time to generate radiation transport models, making it easier to iterate on design details. A first-of-a-kind capability to generate hierarchical void cells is also discussed with preliminary analysis showing performance gains for particle tracking.
Re-Valuation of the Taxonomic Status of Species within the Inocybe similis Complex
Authors: Dovana Francesco , Bandini Ditte , Eberhardt Ursula , Olariaga Ibai , Bizio Enrico , Ferisin Giuliano , Esteve-Raventós Fernando
Published: June 2023

The taxonomy of Inocybe similis and closely allied species is addressed using morphological and molecular data (nrITS and nrLSU DNA). The holotypes of I. chondrospora and I. vulpinella and the isotype of I. immigrans were studied and sequenced. Our results suggest the synonymy between I. similis and I. vulpinella as well as that between I. chondrospora and I. immigrans.
Taxonomic and Phylogenetic Studies of Saprobic Fungi Associated with Mangifera indica in Yunnan, China
Authors: Yang Er-Fu , Dai Dong-Qin , Bhat Jayarama D. , Dawoud Turki M. , Promputtha Itthayakorn , Adikaram Nimal , Stephenson Steven L. , Karunarathna Samantha C. , Tibpromma Saowaluck
Published: June 2023

Fungi are a large and diverse group of microorganisms, and although the estimated number of species ranges between 2 and 11 million, only around 150,000 species have been described thus far. The investigation of plant-associated fungi is beneficial for estimating global fungal diversity, for ecosystem conservation, and for the continued development of industry and agriculture. Mango, one of the world’s five most economically important fruit crops, is grown in over 100 countries and has been demonstrated to have a great economical value. During surveys of mango-associated saprobic fungi in Yunnan (China), we discovered three new species (Acremoniisimulans hongheensis, Chaenothecopsis hongheensis and Hilberina hongheensis) and five new records. The phylogenetic analyses of multi-gene sequences (LSU, SSU, ITS, rpb2, tef1-α and tub2) coupled with morphological examinations were used to identify all the taxa.
Cognitive Flexibility in Hospitalized Patients with Severe or Extreme Anorexia Nervosa: A Case-Control Study
Authors: Hemmingsen Simone Daugaard , Daugaard Nicolaj , Sjögren Magnus , Lichtenstein Mia Beck , Gudex Claire , Piil Frederikke , Støving René Klinkby
Published: June 2023

Objective: To investigate whether cognitive inflexibility could be identified using the Wisconsin Card Sorting Test (WCST) in patients with severe and extreme anorexia nervosa (AN) compared to healthy control participants (HCs). Method: We used the WCST to assess 34 patients with AN (mean age: 25.9 years, mean body mass index (BMI): 13.2 kg/m2) 3–7 days after admission to a specialized nutrition unit and 34 HCs. The Beck Depression Inventory II and the Eating Disorder Inventory 3 were distributed. Results: The patients displayed more perseveration than HCs controlled for age and years of education, with moderate effect sizes (perseverative responses (%): adjusted difference = −7.74, 95% CI: −14.29–(−1.20), p-value: 0.021; perseverative errors (%): adjusted difference = −6.01, 95% CI: −11.06–(−0.96), p-value: 0.020). There were no significant relationships between perseveration and depression, eating disorder symptoms, illness duration, or BMI. Discussion: Patients with severe and extreme AN demonstrated lower cognitive flexibility compared to HCs. Performance was not related to psychopathology or BMI. Patients with severe and extreme anorexia nervosa may not differ from less severe patients in cognitive flexibility performance. As this study exclusively focused on patients suffering from severe and extreme AN, potential correlations might be masked by a floor effect.
Protein Kinase CK2 and SARS-CoV-2: An Expected Interplay Story
Authors: Quezada Meza Camila Paz , Ruzzene Maria
Published: June 2023

Protein kinase CK2 is a Ser/Thr protein kinase that phosphorylates hundreds of substrates mainly related to survival and proliferation pathways. It has long been considered an anti-cancer drug target. However, during the recent COVID-19 pandemic, CK2 inhibitors have been repurposed as anti-SARS-CoV-2 drugs. This was based on the initial finding of CK2 among the proteins of the host cell that interact with the viral proteins and modulate the infection. Since then, several studies have deepened our understanding of the CK2/COVID-19 connection, and we deem it is time to review all the findings. Interestingly, other coronaviruses cross-talk with CK2 as well, with similarities and differences compared to the SARS-CoV-2 case. Therefore, we believe that the analysis of the effects obtained by targeting CK2 in case of coronavirus infections, both at the molecular and phenomenological level, will help in extrapolating information that could be useful not only for COVID-19 (whose pandemic emergency is hopefully turning off) but also for other infections.
Soil Characteristics and Fertility of the Unique Jarrah Forest of Southwestern Australia, with Particular Consideration of Plant Nutrition and Land Rehabilitation
Authors: Soltangheisi Amin , George Suman , Tibbett Mark
Published: June 2023

The jarrah forest is a natural ecosystem with significant endemism in the flora and fauna. The forest stands on the western edge of the ancient Great Plateau of Western Australia on the granitic shield of the Yilgarn craton (2.5 Gya). The long-term migration of soluble iron and aluminium led to the formation of bauxite ore. The regolith ore is bound by surficial topsoil and deep pallid zone kaolinite clays, primarily used in land rehabilitation. We investigated the chemical fertility of the substrates, along with key physical properties. We found the capacity of these soils to provide a stable growth medium differed considerably in their ability to retain and supply nutrients. These substrates are deficient in nitrogen, phosphorus, and micronutrients. In the topsoil, 15% of total P is plant-available, while in the pallid zone layer, only 1% of total P is available. 31P-NMR showed no organic P in the pallid zone, whereas the topsoil had significant organic P and, consequently, a supply of phosphate ions. This shows the importance of organic P in the topsoil for ecosystem nutrition when inorganic fertilisers are not applied in state-of-the-art restoration schemes.
Judicial Review of Mufti Decisions Applying Islamic Family Law in Greece
Authors: Koumoutzis Nikos
Published: June 2023

Greece is a unique example of a country member of the Council of Europe that allows for the application of Sharia law by the Mufti on a select part of its citizenry: the members of the Muslim minority in Western Thrace (situated in NE Greece). However, to produce their effects, Mufti decisions need to undergo review and to be declared enforceable by the civil court. The aim of this article is to explore the relevant legal framework arranged in law 4964/2022 and presidential decree 52/2019, whereby the details of such a judicial review are set out. In particular, this article considers the prerequisite of the exequatur to religious adjudication, and then, it goes through all of the levels over which the said review extends, bringing progressively into focus the review of the scope of jurisdiction, the review of compatibility with the Constitution and the European Convention of Human Rights, and the review of some additional issues raised specifically by presidential decree 52/2019 over and above the points just mentioned. A final remark follows in connection with possible errors committed in religious adjudication—errors of law or fact—which remain beyond the reach of the review.
Practitioner Rehabilitation following Professional Misconduct: A Common Practice Now in Need of a Theory?
Authors: Surgenor Lois J. , Diesfeld Kate , Rychert Marta
Published: June 2023

Theories of rehabilitation have long been articulated in health and criminal justice contexts, driving rehabilitation practices in each area. In this article, several prominent theories are described to illustrate how their core assumptions aim to facilitate recovery and reduce relapse or reoffending. Professional disciplinary bodies are also often compelled by law or regulation to attend to practitioners’ rehabilitation after professional misconduct, with similar aims to restore the practitioner to safe practice. Yet, no rehabilitation theory has been articulated in this context despite professional rehabilitation being distinct from other settings. We propose that the current absence of a coherent theory is problematic, leaving professional disciplinary bodies to ‘borrow’ assumptions from elsewhere. Since rehabilitation penalties are frequently made by professional disciplinary bodies, we review several theories from health and justice contexts and highlight elements that may be useful in developing professional misconduct rehabilitation theory. This includes proposing methodological approaches for empirical research to progress this.