bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethyl Acetate Extract Components of Bushen-Yizhi Formula Provides Neuroprotection against Scopolamine-induced Cognitive Impairment
Authors: Zhang Shi-Jie , Luo Dan , Li Lin , Tan Rui-Rong , Xu Qing-Qing , Qin Jie , Zhu Lei , Luo Na-Chuan , Xu Ting-Ting , Zhang Rong , Yang Lei , Wang Qi
Published: August 2017

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder and there is no effective cure for this devastating disease to date. Bushen Yizhi Formula (BSYZ-F), a Chinese herbal compound, has proved to be effective for AD. In this study, we further investigate the effective part of BSYZ-F, ethyl acetate extract components of BSYZ-F (BSYZ-E), protects scopolamine (SCOP)-induced cognitive impairment, which shows a similar effect to BSYZ-F. We also find that BSYZ-E could protect against SCOP-induced cholinergic system dysfunction. In neuron function level, BSYZ-E remarkably elevates protein levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). BSYZ-E also significantly mitigates SCOP-induced apoptosis, oxidative stress and nitrosative stress. Conclusively, BSYZ-E, the effective part of BSYZ-F, can provide neuroprotection against SCOP-induced cognitive impairment through a multifunctional strategy. These findings suggest that BSYZ-E might be developed as a therapeutic drug for AD by targeting multiple pathways of the pathogenesis.
Three novel obese indicators perform better in monitoring management of metabolic syndrome in type 2 diabetes
Authors: Ma Chun-Ming , Lu Na , Wang Rui , Liu Xiao-Li , Lu Qiang , Yin Fu-Zai
Published: August 2017

The present study evaluated the performance of three novel obese indicators, visceral adiposity index (VAI), lipid accumulation product (LAP) and waist circumference-triglyceride index (WTI), for identifying metabolic syndrome(MetS) in type 2 diabetes. A cross-sectional study was conducted on 711 type 2 diabetes in Qinhuangdao. The MetS was defined as the definition of Chinese Diabetes Society. Receiver operating characteristic curve analyses were performed to assess the accuracy of three obese indicators as diagnostic tests for MetS. The prevalence of MetS was 71.3%. In men, among all three obese indicators, the LAP had the highest area under curve (AUC) value (AUC = 0.894), followed by VAI (AUC = 0.860) and WTI (AUC = 0.855). In women, among all three obese indicators, the LAP had the highest AUC value (AUC = 0.906), followed by WTI (AUC = 0.887) and VAI (AUC = 0.881). However. there was no significant difference between the three obese indicators(P > 0.05). Three obese indicators were effective indicators for the screening of MetS, LAP and WTI are more simple.
A reverse micelle strategy for fabricating magnetic lipase-immobilized nanoparticles with robust enzymatic activity
Authors: Yi Shixiong , Dai Fangyin , Zhao Cunyi , Si Yang
Published: August 2017

Enzyme-immobilized nanoparticles that are both catalysis effective and recyclable would have wide applications ranging from bioengineering and food industry to environmental fields; however, creating such materials has proven extremely challenging. Herein, we present a scalable methodology to create Candida rugosa lipase-immobilized magnetic nanoparticles (L-MNPs) by the combination of nonionic reverse micelle method and Fe3O4 nanoparticles. Our approach causes the naturally abundant and sustainable Candida rugose lipase to ordered-assemble into nanoparticles with high catalytic activity and durability. The resultant L-MNPs exhibit the integrated properties of high porosity, large surface area, fractal dimension, robust enzymatic activity, good durability, and high magnetic saturation (59 emu g−1), which can effectively catalyze pentyl valerate esterification and be easily separated by an external magnet in 60 second. The fabrication of such fascinating L-MNPs may provide new insights for developing functional enzyme-immobilized materials towards various applications.
Dissecting the Molecular Mechanism of the Subcellular Localization and Cell-to-cell Movement of the Sugarcane mosaic virus P3N-PIPO
Authors: Cheng Guangyuan , Dong Meng , Xu Qian , Peng Lei , Yang Zongtao , Wei Taiyun , Xu Jingsheng
Published: August 2017

The coding sequence of P3N-PIPO was cloned by fusion PCR from Sugarcane mosaic virus (SCMV), a main causal agent of sugarcane (Saccharum spp. hybrid) mosaic disease. SCMV P3N-PIPO preferentially localized to the plasma membrane (PM) compared with the plasmodesmata (PD), as demonstrated by transient expression and plasmolysis assays in the leaf epidermal cells of Nicotiana benthamiana. The subcellular localization of the P3N-PIPO mutants P3N-PIPOT1 and P3N-PIPOT2 with 29 and 63 amino acids deleted from the C-terminus of PIPO, respectively, revealed that the 19 amino acids at the N-terminus of PIPO contributed to the PD localization. Interaction assays showed that the 63 amino acids at the C-terminus of PIPO determined the P3N-PIPO interaction with PM-associated Ca2+-binding protein 1, ScPCaP1, which was isolated from the SCMV-susceptible sugarcane cultivar Badila. Like wild-type P3N-PIPO, P3N-PIPOT1 and P3N-PIPOT2 could translocate to neighbouring cells and recruit the SCMV cylindrical inclusion protein to the PM. Thus, interactions with ScPCaP1 may contribute to, but not determine, SCMV Pm3N-PIPO’s localization to the PM or PD. These results also imply the existence of truncated P3N-PIPO in nature.
Phosphatidylinositol-3 Kinase Inhibitors, Buparlisib and Alpelisib, Sensitize Estrogen Receptor-positive Breast Cancer Cells to Tamoxifen
Authors: Chen I-Chun , Hsiao Li-Ping , Huang I-Wen , Yu Huei-Chieh , Yeh Ling-Chun , Lin Ching-Hung , Wei-Wu Chen Tom , Cheng Ann-Lii , Lu Yen-Shen
Published: August 2017

Tamoxifen is the standard first-line hormonal therapy for premenopausal women with estrogen receptor (ER)-positive metastatic breast cancer (BC). One of the crucial mechanisms underlying hormonal therapy resistance is the collateral activation of the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. We explored whether PI3K inhibitors, buparlisib and alpelisib, enhance the efficacy of tamoxifen against ER-positive BC cells. We have observed a synergism between alpelisib or buparlisib and tamoxifen in the treatment for ER-positive BC cell lines harboring different PI3K alterations. Immunoblotting analysis showed alpelisib, buparlisib, or either drug in combination with tamoxifen downregulated the PI3K downstream targets in the MCF-7 and ZR75-1 cells. In the MCF-7 cells transfected with a constitutive active (myristoylated) AKT1 construct or mutant ER, the synergistic effect between alpelisib and tamoxifen was markedly attenuated, indicating that synergism depends on AKT inhibition or normally functioning ER. Combining alpelisib or buparlisib with tamoxifen also attenuated MCF-7 tumor growth in Balb/c nude mice. Our data suggest that additional PI3K blockade might be effective in enhancing the therapeutic effect of tamoxifen in ER-positive BC and support the rationale combination in clinical trials.
Proteomics analysis to reveal biological pathways and predictive proteins in the survival of high-grade serous ovarian cancer
Authors: Xie Hongyu , Wang Wenjie , Sun Fengyu , Deng Kui , Lu Xin , Liu Huijuan , Zhao Weiwei , Zhang Yuanyuan , Zhou Xiaohua , Li Kang , Hou Yan
Published: August 2017

High-grade serous ovarian cancer (HGSC) is an aggressive cancer with a worse clinical outcome. Therefore, studies about the prognosis of HGSC may provide therapeutic avenues to improve patient outcomes. Since genome alteration are manifested at the protein level, we integrated protein and mRNA data of ovarian cancer from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) and utilized the sparse overlapping group lasso (SOGL) method, a new mechanism-driven variable selection method, to select dysregulated pathways and crucial proteins related to the survival of HGSC. We found that biosynthesis of amino acids was the main biological pathway with the best predictive performance (AUC = 0.900). A panel of three proteins, namely EIF2B1, PRPS1L1 and MAPK13 were selected as potential predictive proteins and the risk score consisting of these three proteins has predictive performance for overall survival (OS) and progression free survival (PFS), with AUC of 0.976 and 0.932, respectively. Our study provides additional information for further mechanism and therapeutic avenues to improve patient outcomes in clinical practice.
Alpha-Glucan, Water Dikinase 1 Affects Starch Metabolism and Storage Root Growth in Cassava (Manihot esculenta Crantz)
Authors: Zhou Wenzhi , He Shutao , Naconsie Maliwan , Ma Qiuxiang , Zeeman Samuel C. , Gruissem Wilhelm , Zhang Peng
Published: August 2017

Abstarct

Regulation of storage root development by source strength remains largely unknown. The cassava storage root delay (srd) T-DNA mutant postpones storage root development but manifests normal foliage growth as wild-type plants. The SRD gene was identified as an orthologue of α-glucan, water dikinase 1 (GWD1), whose expression is regulated under conditions of light/dark cycles in leaves and is associated with storage root development. The GWD1-RNAi cassava plants showed both retarded plant and storage root growth, as a result of starch excess phenotypes with reduced photosynthetic capacity and decreased levels of soluble saccharides in their leaves. These leaves contained starch granules having greatly increased amylose content and type C semi-crystalline structures with increased short chains that suggested storage starch. In storage roots of GWD1-RNAi lines, maltose content was dramatically decreased and starches with much lower phosphorylation levels showed a drastically reduced β-amylolytic rate. These results suggested that GWD1 regulates transient starch morphogenesis and storage root growth by decreasing photo-assimilation partitioning from the source to the sink and by starch mobilization in root crops.
Hydrogen enhances strength and ductility of an equiatomic high-entropy alloy
Authors: Luo Hong , Li Zhiming , Raabe Dierk
Published: August 2017

Metals are key materials for modern manufacturing and infrastructures as well as transpot and energy solutions owing to their strength and formability. These properties can severely deteriorate when they contain hydrogen, leading to unpredictable failure, an effect called hydrogen embrittlement. Here we report that hydrogen in an equiatomic CoCrFeMnNi high-entropy alloy (HEA) leads not to catastrophic weakening, but instead increases both, its strength and ductility. While HEAs originally aimed at entropy-driven phase stabilization, hydrogen blending acts opposite as it reduces phase stability. This effect, quantified by the alloy’s stacking fault energy, enables nanotwinning which increases the material’s work-hardening. These results turn a bane into a boon: hydrogen does not generally act as a harmful impurity, but can be utilized for tuning beneficial hardening mechanisms. This opens new pathways for the design of strong, ductile, and hydrogen tolerant materials.
Sensitive and selective detection of the p53 gene based on a triple-helix magnetic probe coupled to a fluorescent liposome hybridization assembly via rolling circle amplification
Authors: Li Xia , Song Juan , Xue Qingwang , Zhao Haiyan , Liu Min , Chen Baoli , Liu Yun , Jiang Wei , Li Chen-zhong
Published: August 2017

Developing a sensitive and selective sensing platform for the p53 gene and its mutation analysis is essential and may aid in early cancer screening and assessment of prognosis.
Surface modification of ZnO nanostructured electrodes with thiol and phosphonic acid moieties for biosensing applications
Authors: Shanmugam N. R. , Muthukumar S. , Prasad S.
Published: August 2017

The analytical performance of affinity immunoassay based biosensor systems is determined by the efficiency of capture probe immobilization, which in turn depends on the stability of surface modification.
High yielding and extremely site-selective covalent functionalization of graphene
Authors: Navarro Juan Jesús , Calleja Fabián , Miranda Rodolfo , Pérez Emilio M. , Vázquez de Parga Amadeo L.
Published: August 2017

Gr/Ru(0001) can be functionalized covalently in high yield (92%) and selectivity (98%) with CH2CN˙ and increasing the sample temperature during functionalization.
Reversible structural switching of a metal–organic framework by photoirradiation
Authors: Nikolayenko Varvara I. , Herbert Simon A. , Barbour Leonard J.
Published: August 2017

A photoresponsive metal organic framework material undergoes switching of its pore volume and sorption capacity.
Crystalline-phase-induced formation of fibre-in-tube TiO2–SnO2 fibres for a humidity sensor
Authors: Wang Yun , Zhao Xiaojuan , Feng Zhongmin , Lu Geyu , Sun Ting , Xu Yan
Published: August 2017

We provide a general crystalline-phase-induced strategy for the fabrication of fibre-in-tube TiO2–SnO2 materials for a high-sensitivity humidity sensor.
Phase and morphology evolution of ultrathin Co(OH)2nanosheets towards supercapacitor application
Authors: Ding Kun , Zhang Xiao , Li Juping , Yang Ping , Cheng Xin
Published: August 2017

The morphology and phase evolution strongly depends on a hydrothermal process driven by kinetics and thermodynamics.
The adsorption of Cu on the CeO2(110) surface
Authors: Chutia Arunabhiram , Gibson Emma K. , Farrow Matthew R. , Wells Peter P. , Scanlon David O. , Dimitratos Nikolaos , Willock David J. , Catlow C. Richard A.
Published: August 2017

A detailed density functional theory (DFT) study coupled with extended X-ray absorption fine structure (EXAFS) experiments on the geometrical and electronic properties of copper species on CeO2 surface demonstrating the effects of oxidation state and solvent environment.
Elastic and viscous bond components in the adhesion of colloidal particles and fibrillated streptococci to QCM-D crystal surfaces with different hydrophobicities using Kelvin–Voigt and Maxwell models
Authors: van der Westen Rebecca , Sharma Prashant K. , De Raedt Hans , Vermue Ijsbrand , van der Mei Henny C. , Busscher Henk J.
Published: August 2017

Analysis of initial bacterial adhesion using phenomenological models such as the Kelvin–Voigt model and the Maxwell model.
Nickel–iron alloy catalysts for reforming of hydrocarbons: preparation, structure, and catalytic properties
Authors: Tomishige Keiichi , Li Dalin , Tamura Masazumi , Nakagawa Yoshinao
Published: August 2017

Among various methods for preparation of supported Ni–Fe alloy catalysts, reduction of oxides containing both Ni2+ and Fe3+ can give uniform alloy particles with high catalytic performance for reforming of hydrocarbons.
Comparison of indoor air sampling and dust collection methods for fungal exposure assessment using quantitative PCR
Authors: Cox Jennie , Indugula Reshmi , Vesper Stephen , Zhu Zheng , Jandarov Roman , Reponen Tiina
Published: August 2017

Evaluating fungal contamination indoors is complicated because of the many different sampling methods utilized.
The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)
Authors: McKenna S. M. , Mines P. , Law P. , Kovacs-Schreiner K. , Birmingham W. R. , Turner N. J. , Leimkühler S. , Carnell A. J.
Published: August 2017

One-pot multienzyme continuous cascade for the conversion of HMF to FDCA using HRP to activate GOaseM3-5 in situ.
Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative
Authors: Liu Min , Zhang Chunxia , Ding Mingruo , Tang Bencan , Zhang Fengzhi
Published: August 2017

A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivatives with readily available aniline derivatives as starting materials.
A green and clean pathway: one pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-c]pyrazoles under catalyst-free and solvent-free conditions
Authors: Pati Tripathi Bhartendu , Mishra Anu , Rai Pratibha , Kumar Pandey Yogesh , Srivastava Madhulika , Yadav Snehlata , Singh Jaya , Singh Jagdamba
Published: August 2017

Visible light mediated, an eco-friendlier synthetic protocol for dihydropyrano[2,3-c]pyrazoles via catalyst-free and solvent-free conditions at room temperature.
Poly-N-acryloyl-(l-phenylalanine methyl ester) hollow core nanocapsules facilitate sustained delivery of immunomodulatory drugs and exhibit adjuvant properties
Authors: Yamala Anil Kumar , Nadella Vinod , Mastai Yitzhak , Prakash Hridayesh , Paik Pradip
Published: August 2017

Polymeric hollow nanocapsules have attracted significant research attention as novel drug carriers and their preparation is of particular concern owing to the feasibility to encapsulate a broad range of drug molecules.
Lipid nanodomains change ion channel function
Authors: Weinrich Michael , Worcester David L. , Bezrukov Sergey M.
Published: August 2017

Two distinct lifetimes are observed for gramicidin channels in model lipid raft membranes exhibiting lateral domain separation at the nanoscale.
Rotational superstructure in van der Waals heterostructure of self-assembled C60 monolayer on the WSe2 surface
Authors: Santos Elton J. G. , Scullion Declan , Chu Ximo S. , Li Duo O. , Guisinger Nathan P. , Wang Qing Hua
Published: August 2017

Hybrid van der Waals (vdW) heterostructures composed of two-dimensional (2D) layered materials and self-assembled organic molecules are promising systems for electronic and optoelectronic applications with enhanced properties and performance.
Multivalent gold nanoparticle–peptide conjugates for targeting intracellular bacterial infections
Authors: Chowdhury Rimi , Ilyas Humaira , Ghosh Anirban , Ali Haydar , Ghorai Arup , Midya Anupam , Jana Nikhil R. , Das Santasabuj , Bhunia Anirban
Published: August 2017

This study identifies and characterizes a gold nano-particle tagged antimicrobial peptide that can internalize cells and kill intracellular bacteria without being cytotoxic. It can also considerably reduceS.Typhi infection in animal model.
Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic
Authors: Roberts-Dalton H. D. , Cocks A. , Falcon-Perez J. M. , Sayers E. J. , Webber J. P. , Watson P. , Clayton A. , Jones A. T.
Published: August 2017

Prostate cancer EVs remain differentiation competent when fluorescently labelled using a novel thiol-based method, allowing exploration of their endocytosis and trafficking.
97 percent light absorption in an ultrabroadband frequency range utilizing an ultrathin metal layer: randomly oriented, densely packed dielectric nanowires as an excellent light trapping scaffold
Authors: Ghobadi Amir , Dereshgi Sina Abedini , Hajian Hodjat , Birant Gizem , Butun Bayram , Bek Alpan , Ozbay Ekmel
Published: August 2017

Randomly oriented dielectric nanowires, coated with an ultrathin absorbing layer, provide near perfect absorption in an ultrabroadband frequency range.
Size-dependent abnormal thermo-enhanced luminescence of ytterbium-doped nanoparticles
Authors: Cui Xiangshui , Cheng Yao , Lin Hang , Huang Feng , Wu Qingping , Wang Yuansheng
Published: August 2017

The suppression of energy migration-mediated surface quenching with increasing temperature leads to the abnormal thermo-enhanced photoluminescence of LNP.
Large-scale immuno-magnetic cell sorting of T cells based on a self-designed high-throughput system for potential clinical application
Authors: Zhang Qian , Yin Ting , Xu Rongrong , Gao Wenjun , Zhao Hui , Shapter Joseph G. , Wang Kan , Shen Yulan , Huang Peng , Gao Guo , Wu Yanfeng , Cui Daxiang
Published: August 2017

A self-designed high-throughput system has been developed for large-scale immuno-magnetic cell sorting of different T cells.
201Tl-labeled Prussian blue and Au@Prussian blue nanoprobes for SPEC-CT imaging: influence of the size, shape and coating on the biodistribution
Authors: Maurin-Pasturel Guillaume , Rascol Estelle , Busson Muriel , Sevestre Samuel , Lai-Kee-Him Joséphine , Bron Patrick , Long Jérôme , Chopineau Joël , Devoisselle Jean-Marie , Guari Yannick , Larionova Joulia
Published: August 2017

201Tl-labeled Prussian blue and core@shell Au@Prussian blue nanoparticles coated with the phospholipidic bilayer and dextran were investigated in vivo as nanoprobes by usingSPECT-CT scintigraphy.
Chemical etching of graphene-supported PdPt alloy nanocubes into concave nanostructures for enhanced catalytic hydrogen production from alkaline formaldehyde aqueous solution
Authors: Xu Zaixiang , Zhu Yuzhen , Bai Lijie , Lang Qingqing , Hu Wenli , Gao Chunxiao , Zhong Shuxian , Bai Song
Published: August 2017

Graphene-supported PdPt concave nanostructures with different degrees of concavity were synthesized by etching PdPt nanocubes for enhanced catalytic hydrogen production from alkaline formaldehyde aqueous solution.
Optimization of thermoelectric properties of n-type Ti, Pb co-doped SnSe
Authors: Li Fu , Wang Wenting , Qiu Xincheng , Zheng Zhuanghao , Fan Ping , Luo Jingting , Li Bo
Published: August 2017

Improved electrical conductivity together with reduced lattice thermal conductivity is achieved for n-type cation-site Ti, Pb co-doped SnSe, resulting in an optimized thermoelectric property.
Gasochromic properties of novel tungsten oxide thin films compounded with methyltrimethoxysilane (MTMS)
Authors: Zhang Zenghai , Guan Dayong , Gao Guohua , Wu Guangming , Wang Haoran
Published: August 2017

Thick tungsten–silicon films with long-term gasochromic performance were synthesized from methyltrimethoxysilane (MTMS) and tungsten oxide sols. The WO3–MTMS films exhibited a stable network with tungsten and silicon bonds.
Effects of Rhizoma Parisdis total saponins and its main compounds on gastric emptying via regulating muscarinic receptors in vitro and in vivo
Authors: Wang Yu , Liu Yuanxue , Wang Genbei , Han Liying , Xia Ting , Liu Zhen , Man Shuli , Gao Wenyuan , Liu Changxiao
Published: August 2017

The aim of this study was to explore the inhibitory effect of Rhizoma Parisdis total Saponins (RPS) and the main monomer compounds (polyphyllin I, II, VI and H) on gastric emptying and gastrointestinal motilityin vitroandin vivo.
Structure and photoluminescence properties of novel Sr6Ca4(PO4)6F2:Re (Re = Eu2+, Mn2+) phosphors with energy transfer for white-emitting LEDs
Authors: Xu Hongwei , Wang Lili , Qu Dan , Si Zhiyun , Shi Jinsheng
Published: August 2017

A series of Sr6Ca4(PO4)6F2:Eu2+,Mn2+ phosphors were synthesized by traditional solid state reaction. Through controlling the ratio of Eu2+ and Mn2+, emission colors can be tuned from blue to yellow, including white-light-emitting.
Promiscuity of inhibitors of human protein kinases at varying data confidence levels and test frequencies
Authors: Stumpfe Dagmar , Tinivella Annachiara , Rastelli Giulio , Bajorath Jürgen
Published: August 2017

Kinase inhibitors from screening data. Shown are two analogs that were tested against 10 (left) and 13 (right) different kinases. The inhibitor on the left was active against a single kinase and the one on the right against three kinases.
Preparation and optical properties of magnetic carbon/iron oxide hybrid dots
Authors: Hu Yin , Wang Ping , Bunker Christopher E. , Teisl Lindsay R. , Reibold McIver , Yan Sijia , Qian Haijun , He Dawei , Sun Ya-Ping
Published: August 2017

Carbon/Fe3O4 hybrid dots are prepared for their optical properties in reference to those of neat carbon dots.
Rapid production of Pd nanoparticle by a marine electrochemically active bacterium Shewanella sp. CNZ-1 and its catalytic performance on 4-nitrophenol reduction
Authors: Zhang Haikun , Hu Xiaoke
Published: August 2017

Microbial recovery of Pd through Pd(ii) reduction is emerging as a clean alternative to traditional physical and chemical reclaiming treatments.
Synthesis of 2′-O-monohaloethoxymethyl-modified RNAs and their duplex formation ability
Authors: Hara Rintaro Iwata , Kageyama Masayuki , Arai Koichiro , Uchiyama Naoki , Wada Takeshi
Published: August 2017

We synthesized 2′-O-monohaloethoxymethyl-modified RNAs and evaluated their duplex formation ability.
Multi-functional bis(alkynyl)gold(iii) N⁁C complexes with distinct mechanochromic luminescence and electroluminescence properties
Authors: Wong Ben Yiu-Wing , Wong Hok-Lai , Wong Yi-Chun , Au Vonika Ka-Man , Chan Mei-Yee , Yam Vivian Wing-Wah
Published: August 2017

A new class of highly luminescent bis(alkynyl)gold(iii) N⁁C complexes has been utilized as emissive materials in OLEDs and exhibits mechanochromic behaviors.
Immuno-targeting of Staphylococcus aureus via surface remodeling complexes
Authors: Sabulski Mary J. , Pidgeon Sean E. , Pires Marcos M.
Published: August 2017

A novel immunomodulatory strategy is described that targets bacteria for destruction.
Micro-mechanical, continuum-mechanical, and AFM-based descriptions of elasticity in open cylindrical micellar filaments
Authors: Asgari Meisam
Published: August 2017

We present theoretical and experimental descriptions of the elasticity of cylindrical micellar filaments using micro-mechanical and continuum theories, and atomic force microscopy.
In situ preparation of a binder-free nano-cotton-like CuO–Cu integrated anode on a current collector by laser ablation oxidation for long cycle life Li-ion batteries
Authors: Liang Peng , Zhang Hongjun , Su Yibo , Huang Zeya , Wang Chang-An , Zhong Minlin
Published: August 2017

In situ preparation of a long cycle life CuO–Cu integrated anode on a Cu current collector by one-step laser ablation.
Co-assembly of photosystem II in nanotubular indium–tin oxide multilayer films templated by cellulose substance for photocurrent generation
Authors: Li Jiao , Feng Xiyun , Jia Yi , Yang Yang , Cai Peng , Huang Jianguo , Li Junbai
Published: August 2017

Co-assembly of photosystem II in a nanotubular indium–tin oxide matrix templated by natural cellulose for solar energy conversion into electrical power.
Performance and DRT analysis of P-SOFCs fabricated using new phase inversion combined tape casting technology
Authors: Shi Nai , Su Feng , Huan Daoming , Xie Yun , Lin Jie , Tan Wenzhou , Peng Ranran , Xia Changrong , Chen Chusheng , Lu Yalin
Published: August 2017

Phase-inversion combined tape casting technology was applied to fabricate P-SOFCs, which demonstrated great performance for CH3OH containing fuel.
Hydrogen storage in polymer-based processable microporous composites
Authors: Rochat Sébastien , Polak-Kraśna Katarzyna , Tian Mi , Holyfield Leighton T. , Mays Timothy J. , Bowen Christopher R. , Burrows Andrew D.
Published: August 2017

Microporous polymer-based membranes (PIM-1) doped with a porous aromatic framework (PAF-1) combine mechanical flexibility with enhanced hydrogen uptake capacities: they can potentially store up to 6.7 wt% H2at 77 K.
Insights into the stable layered structure of a Li-rich cathode material for lithium-ion batteries
Authors: An Juan , Shi Liyi , Chen Guorong , Li Musen , Liu Hongjiang , Yuan Shuai , Chen Shimou , Zhang Dengsong
Published: August 2017

In this work, we doped sulfur into the oxygen layers of a lithium-rich layered metal oxide (LNMO) cathode material for lithium-ion batteries to improve the structural stability and cycling performance.
Carbon dots anchored on octahedral CoO as a stable visible-light-responsive composite photocatalyst for overall water splitting
Authors: Shi Weilong , Guo Feng , Zhu Cheng , Wang Huibo , Li Hao , Huang Hui , Liu Yang , Kang Zhenhui
Published: August 2017

CDs/CoO photocatalysts with enhanced photocatalytic overall water splitting activity and stability were prepared through a facile solvothermal method.
Ionic liquid-assisted synthesis of α-Fe2O3 mesoporous nanorod arrays and their excellent trimethylamine gas-sensing properties for monitoring fish freshness
Authors: Wang Ping , Zheng Zhikun , Cheng Xiaoli , Sui Lili , Gao Shan , Zhang Xianfa , Xu Yingming , Zhao Hui , Huo Lihua
Published: August 2017

Mesoporous α-Fe2O3 nanorod arrays sensor, with appropriate amount of [C12mim][Br] retention, exhibits excellent sensitivity to trimethylamine and good anti-humidity ability at 217 °C, which can be used in identification of fish freshness.
Heterogeneity of mesenchymal and pluripotent stem cell populations grown on nanogrooves and nanopillars
Authors: Wang Peng-Yuan , Ding Sheryl , Sumer Huseyin , Wong Raymond Ching-Bong , Kingshott Peter
Published: August 2017

Surface nanotopographies are a powerful way of manipulating cell morphology and subsequent differentiation.
A simple approach to synthetize folic acid decorated magnetite@SiO2 nanostructures for hyperthermia applications
Authors: Bettini S. , Giancane G. , Pagano R. , Bonfrate V. , Salvatore L. , Madaghiele M. , Buccolieri A. , Manno D. , Serra A. , Maruccio G. , Monteduro A. G. , Syrgiannis Z. , Valli L. , Prato M.
Published: August 2017

Folic Acid decorated SPIONs selective internalization was monitored by an innovative Ellipsometry imaging approach.
The influence of precursor on rhenium incorporation into Re-doped MoS2 (Mo1−xRexS2) thin films by aerosol-assisted chemical vapour deposition (AACVD)
Authors: Al-Dulaimi Naktal , Lewis Edward A. , Savjani Nicky , McNaughter Paul D. , Haigh Sarah J. , Malik M. Azad , Lewis David J. , O’Brien Paul
Published: August 2017

The molecular precursors [Mo(S2CNEt2)4] (1), [Re(S2CC6H5)(S3CC6H5)2] (2), and [Re2(μ-S)2(S2CNEt2)4] (3) were used to deposit thin films of Re-doped MoS2.
Ln3+-Sensitized Mn4+near-infrared upconverting luminescence and dual-modal temperature sensing
Authors: Chen Daqin , Xu Wei , Yuan Shuo , Li Xinyue , Zhong Jiasong
Published: August 2017

In the past few decades, efficient photon upconversion (anti-Stokes) luminescence has been extensively studied and is almost exclusively restricted to lanthanide (Ln3+) doped fluorophores.
Isomeric ligands enhance the anisotropy barrier within nine-coordinated {Dy2} compounds
Authors: Sun Lin , Wei Shilong , Zhang Jun , Wang Wenyuan , Chen Sanping , Zhang Yiquan , Wei Qing , Xie Gang , Gao Shengli
Published: August 2017

Two nine-coordinated Dy2 compounds (1 and 2) were obtained on the basis of isomeric ligands. Magnetic studies revealed that compound 2 possesses higher Ueff in nine-coordinated Dy2 compounds.
Formation of MoO3 and WO3 nanoscrolls from MoS2 and WS2 with atmospheric air plasma
Authors: Chu Ximo S. , Li Duo O. , Green Alexander A. , Wang Qing Hua
Published: August 2017

Transition metal oxides in nanoscroll geometries are synthesized from two-dimensional layered precursors by plasma treatment.
Benefits of surfactant effects on quantum efficiency enhancement and temperature sensing behavior of NaBiF4 upconversion nanoparticles
Authors: Lei Pengpeng , An Ran , Zhai Xuesong , Yao Shuang , Dong Lile , Xu Xia , Du Kaimin , Zhang Manli , Feng Jing , Zhang Hongjie
Published: August 2017

The modification of PAA on the surface of NaBiF4:Yb3+/Er3+ UCNPs could effectively improve the UCL quantum yield and temperature sensing behavior of the UCNPs.
New self‐organising hierarchical PSO with jumping time‐varying acceleration coefficients
Authors: Ghasemi M. , Aghaei J. , Hadipour M.
Published: August 2017

Without doubt, one of the powerful and effective optimiser in the area of evolutionary algorithms and improved particle swarm optimisation (PSO) is the self‐organising hierarchical PSO with time‐varying acceleration coefficients (HPSO‐TVAC) which has been implemented successfully in the many problems (cited by 2430 until now). Real‐world problems are multi‐variable problems with real‐world different complexities. The classical HPSO‐TVAC optimisation technique often converges to local optima solution for some of the real‐world problems. Therefore, finding efficient modern versions of the PSO algorithm (here HPSO‐TVAC) to solve the real‐world problems are absorbing a growing attention in recent years. A novel HPSO‐TVAC algorithm for real‐world optimisation is proposed. The simulation results show that proposed HPSO‐TVAC new version, NHPSO‐JTVAC, is powerful and very competitive for real‐world optimisation.
Diastereoselective Palladium-Catalyzed Conjugate Addition of Arylboronic Acids to α-Substituted Cyclic Enones
Authors: Gao Ang , Liu Xiu-Yan , Ding Chang-Hua , Hou Xue-Long
Published: August 2017

A palladium-catalyzed conjugate addition of arylboronic acids to α-substituted cyclic enones was developed to give α,β-disubstituted ketones with high diastereoselectivity. Mechanistic investigation showed that the high diastereoselectivity was realized through epimerization.
The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization
Authors: Besset Tatiana , Zhao Qun , Poisson Thomas , Pannecoucke Xavier
Published: August 2017

In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances.

1 Introduction

2 From a Historical Point of View

3 Functionalization of Carbonyl Derivatives

4 Functionalization of Amines Derivatives

5 Summary and Outlook
Synthesis of Functionalized Cyclopentene Derivatives through Gold-Catalyzed Reaction of Stabilized Vinyldiazo Compounds and Styrenes
Authors: López Luis , López Enol , Lonzi Giacomo
Published: August 2017

The reaction of alkenyldiazo compounds with styrene derivatives in the presence of [Au(IPr)(MeCN)][SbF6] provided cyclopentene derivatives resulting from a formal [3+2] cycloaddition reaction as major products. This reaction outcome stands in marked contrast to that previously observed for other olefinic derivatives. From a mechanistic point of view, this process would involve the initial generation of a highly electrophilic alkenylgold carbene intermediate, which would be subsequently involved in a stepwise carbocationic process.
Endovascular Extraction of a Needle from the Internal Carotid Artery: A Novel Approach to a Controversial Dental Misadventure
Authors: Giurintano Jonathan , Somerville Jessica , Sebelik Merry , Hoit Daniel , Michael L. , Shires Courtney
Published: August 2017

Objective To review the literature concerning the management of dental needles broken off into the deep spaces of the neck, to report what we believe is the first case of a fractured dental needle migrating into the jugular foramen, and the unconventional use of endovascular intervention to retrieve the needle fragment.

Design Case report with review of literature.

Setting Academic tertiary care center.

Participants Intervention was performed by the otolaryngology–head and neck surgery, vascular surgery, and neurovascular interventional radiology teams.

Results Transoral exploration, including palatal split and exposure of the poststyloid parapharyngeal space with C-arm image guidance, was unable to retrieve the broken needle, which traversed the internal carotid lumen with the distal end entering the jugular foramen. Through endovascular intervention, the neurovascular interventional radiology team captured the proximal end of the needle and retrieved it through the femoral artery. The patient recovered uneventfully.

Conclusion Fracture and loss of oral injection needles remain a persistent and preventable problem. This case demonstrates a novel, minimally invasive, well-tolerated, and successful method to extract a fractured needle that migrated into the lumen of the internal carotid artery at the level of the skull base.
Razonamiento Quirúrgico en Inestabilidad Crónica Posterolateral de Rodilla
Authors: Díaz Allende Pedro
Published: August 2017

Los pacientes con mal alineamiento en varo pueden ser difíciles de tratar cuando tienen una lesión crónica de la esquina posterolateral (EPL), resultando en doble o triple varo y subsecuentemente varus thrust durante la marcha. Una osteotomía tibial alta es un procedimiento útil y necesario particularmente en el estadío crónico. Este artículo revisa los fundamentos de la planificación preoperatoria en una lesión crónica de la EPL.
Knowledge and Compliance in Practices in Diagnosis and Treatment of Syphilis in Maternity Hospitals in Teresina - PI, Brazil
Authors: Santos Raquel Rodrigues dos , Niquini Roberta Pereira , Domingues Rosa Maria Soares Madeira , Bastos Francisco Inácio
Published: August 2017

Objective To assess the knowledge and compliance of health professionals regarding the diagnostic and treatment practices for syphilis in patients admitted for childbirth in public maternity hospitals in the city of Teresina, in the state of Piauí, Northeastern Brazil.

Methods A cross-sectional study was performed in 2015 with obstetricians and nurses working in the public maternity hospitals in Teresina (n = 159) using a self-administered questionnaire, with 5% of losses and 10% of refusals. The study used 21 evaluation criteria: 13 of them were related to knowledge (5 on serological tests and 8 on treatment adequacy); 8 were related to practices (3 on diagnosis, 4 on treatment, and 1 on post-test counseling). The knowledge of and compliance to the practices was estimated as the proportion of health professionals' answers that were in agreement with Brazilian Ministry of Health protocols.

Results The obstetricians were in agreement with two criteria concerning the knowledge of serological tests, one for diagnostic practices, and one for treatment practice. Among nurses, no single match between actual procedures and guidelines was observed.

Conclusions Low compliance with the protocols results in missed opportunities for the diagnosis and treatment of pregnant and postpartum women and their partners. Strategies for training and integrating the various professional groups, improved data recording on prenatal cards, and greater accountability of the hospital team in managing the women's partners are needed to overcome the barriers identified in the study and to interrupt the syphilis transmission chain.
Rotura espontánea del tendón extensor largo del pulgar – transferencia tendínea con técnica anestésica WALANT
Authors: Sanhueza Faúndez Miguel , Azócar Sanhueza Camila , Carrasco Penna Gabriel
Published: August 2017

La rotura espontanea del tendón extensor largo del pulgar (ELP), es una patología infrecuente existiendo casos reportados en la literatura donde no se logra encontrar factores predisponentes. El manejo quirúrgico suele realizarse utilizando una técnica de transposición tendínea del tendón del extensor propio del índice. En la actualidad, la técnica anestésica de WALANT “Wide Awake Local Anesthesia with No-Torniquet” ha sido de amplio desarrollo en la cirugía de la mano, sobre todo para la resolución quirúrgica de patología de tendones, con buenos y excelentes resultados. Se presenta un caso de un paciente con rotura espontánea del tendón ELP, que fue manejado con una transferencia tendínea utilizando la técnica anestésica WALANT.
Surgical Strategy for Dermoid and Epidermoid Tumors of the Posterior Fossa - Experience with 21 Patients
Authors: Lynch José , Welling Leonardo , Aversa Antonio , Esteves Celestino , Nogueira Jânio , Gonçalves Mariângela , Lopes Hélio
Published: August 2017

Objective The aim of this paper is to describe our surgical strategy and technique and to identify the best management for posterior fossa dermoid and epidermoid tumors (PFDETs).

Methods We retrospectively identified 21 consecutive patients (11 males and 10 females), with a mean age of 33.2 years, a mean follow-up of 6.1 years, and pathologically confirmed PFDETs. Total 17 patients were submitted to the extended retrosigmoid approach. This approach incorporates transverse sigmoid sinus exposure and a generous mastoidectomy.

Results Gross total tumor removal was achieved in 16 (76.1%) cases, with no surgical mortality and a recurrence rate of 9.5%.

Conclusions The surgical strategies used in this group of patients enabled the total removal of most tumors without surgical mortality and with minimal morbidity and recurrence rates. The extended retrosigmoid approach used is an alternative path regarding cranial base approaches. This approach is quick, simple and safe, and decreases the retraction of the cerebellum.
Informieren, interpretieren, interagieren
Authors: Hillmer Lisa
Published: August 2017

Kommunikation im OP-Team Der Risikobereich OP wird oft mit einem
Flugzeug-Cockpit verglichen. Durch zahlreiche Studien ist bekannt, dass die
meisten Flugunfälle auf mangelhafte Kommunikation und Interaktion im Team
zurückzuführen sind 1 – das Gleiche gilt auch
für Fehler, die im OP passieren. Unsere Autorin hat untersucht, wodurch
Kommunikation im OP-Team beeinflusst wird und wie sie optimiert werden kann, um
Missverständnisse zu vermeiden.
Clinical Value of Contrast Enema Prior to Ileostomy Closure
Authors: Goetz Andrea , da Silva Natascha , Moser Christian , Agha Ayman , Dendl Lena-Marie , Stroszczynski Christian , Schreyer Andreas
Published: August 2017

Purpose To determine the value of routine contrast enema of loop ileostomy before elective ileostomy closure regarding the influence on the clinical decision-making.

Materials and Methods Retrospective analysis of contrast enemas at a tertiary care center between 2005 und 2011. Patients were divided into two groups: Group I with ileostomy reversal, group II without ileostomy closure. Patient-related parameters (underlying disease, operation method) and parameters based on the findings (stenosis, leakage of anastomosis, incontinence) were evaluated.

Results Analyzing a total of 252 patients in 89 % (group I, n = 225) ileostomy closure was performed. In 15 % the radiologic report was the only diagnostic modality needed for therapy decision; in 36 % the contrast enema and one or more other diagnostic methods were decisive. In 36 % the radiological report of the contrast imaging was not relevant for decision at all. In 11 % (group II, n = 27) no ileostomy closure was performed. In this group in 11 % the radiological report of the contrast enema was the only decision factor for not performing the ileostomy reversal. In 26 % one or more examination was necessary. In 26 % the result of the contrast examination was not relevant.

Conclusion The radiologic contrast imaging of loop ileostomy solely plays a minor role in complex surgical decision-making before planned reversal, but is important as first imaging method in detecting complications and often leads to additional examinations.

Key points 

Citation Format
Betriebliches Gesundheitsmanagement und Betriebsrat – Hürden und Potenziale in der
Zusammenarbeit mit Arbeitnehmervertretungen
Authors: Lange M.
Published: August 2017

Der Erfolg von Maßnahmen im Rahmen des betrieblichen Gesundheitsmanagements ist stark von der
Zusammenarbeit verschiedener Interessenparteien wie die der Arbeitnehmer, der Arbeitgeber und der
Arbeitnehmervertretung geprägt. Die Rolle der Arbeitnehmervertretung gestaltet sich je nach Kontext
unterschiedlich und kann für eine erfolgreiche Umsetzung sowohl förderlich als auch hinderlich sein. Als
Grundlage für eine ergebnisorientierte Zusammenarbeit zwischen Arbeitgeber und Arbeitnehmervertretung
gelten verschiedene Gesetzesgrundlagen, die den Akteuren nur selten bekannt sind. Ziel dieses Beitrags
ist es, einen groben rechtlichen Rahmen im Kontext des betrieblichen Gesundheitsmanagements aufzuzeigen
und somit die Hürden und Potenziale in der Zusammenarbeit mit Arbeitnehmervertretungen zu optimieren. Die
Inhalte des Beitrags richten sich an betriebliche Gesundheitsberater, Arbeitnehmervertreter und andere
Interessierte.
Betriebliche Gesundheitskommunikation: Strategischer Einsatz von Kommunikationsinstrumenten
und Gesundheitsbrokern
Authors: Wäsche H.
Published: August 2017

Um den Erfolg von Maßnahmen des Betrieblichen Gesundheitsmanagements zu gewährleisten, ist es notwendig,
gezielt Kommunikationsstrategien zu entwickeln, um weniger gesundheitsaffine und schwer erreichbare
Mitarbeiter zu erreichen. Im vorliegenden Beitrag wird ein systematischer Ansatz der Betrieblichen
Gesundheitskommunikation entworfen und die Rolle des Gesundheitsbrokers darin herausgearbeitet. Durch
eine Verknüpfung und Integration verschiedener Konzepte der Marketingkommunikation, des
Gesundheitsverhaltens sowie der Netzwerktheorie lässt sich ein umfassender und problembezogener Ansatz
der Strategieentwicklung in der Betrieblichen Gesundheitskommunikation konzipieren.
BGF im Kontext des Präventionsgesetzes – Herausforderungen an eine gesetzliche
Krankenkasse
Authors: Vockert T.
Published: August 2017

Im Bereich der betrieblichen Gesundheitsförderung birgt das Präventionsgesetz Potenziale und
Herausforderungen für gesetzliche Krankenkassen. Im Sinne einer nachhaltigen
Gesundheitsförderung im Setting Betrieb können zukünftige Chancen darin liegen, sowohl
Angebote der teilweise in Konkurrenz stehenden Akteure zu verzahnen sowie bestehende
Strukturen der Lebenswelt übergreifend zu nutzen.
Wiederaufbau der Brust
Authors: Schwind Margot , Gonzalez-Heiberger Edgar
Published: August 2017

OP-Ablauf Nach einer Brustamputation besteht die Möglichkeit, mit einer
Aufbauplastik das äußere Erscheinungsbild der Patientin wiederherzustellen. Wir
haben dem Team des Leopoldina-Krankenhauses Schweinfurt bei der
skin-and-nipple-sparing Mastektomie mit implantatgestütztem Wiederaufbau über
die Schulter geschaut.
Chronifizierungsprophylaxe von Anfang an – Schmerzprogramme für Kinder
Authors: Steinberger Martin
Published: August 2017

Chronische Schmerzen bei Kindern und Jugendlichen können beträchtliche Auswirkungen auf die Lebensqualität der betroffenen Kinder und deren Familien haben. Inzwischen werden eine ganze Reihe von Therapiemaßnahmen unter dem Begriff „Schmerzprogramme“ angeboten, die von mehrwöchigen stationären Klinikaufenthalten bis hin zu eigenverantwortlich anwendbaren internetbasierten Trainings reichen. Bei chronischen Schmerzen haben sich auch bei Kindern intensive interdisziplinäre multimodale Therapieformen bewährt.
ADHS: Ursachen und Behandlungsmöglichkeiten
Authors: Ogal Mercedes
Published: August 2017

Der Beitrag stellt den aktuellen Stand der möglichen Ursachen/Auslöser in Bezug auf ein primäres AD(H)S (ADHS=Aufmerksamkeitsdefizit-Hyperaktivitäts-Syndrom) dar. Die aktuellen Erkenntnisse sprechen für eine multifaktorielle Genese, ein komplexes, bisher wenig verstandenes Zusammenspiel aus neurobiologischen, genetischen, psychischen und sozialen Faktoren. Mehr oder weniger ausgeprägt spricht man von einer Funktionsstörung des Gehirns in den Bereichen Problemlösung, Planung und Impulskontrolle. Die Ursachen für ein sekundäres AD(H)S werden nur am Rande gestreift, da diese auf die persönlichen Lebensumstände des jeweiligen Kindes zurückzuführen sind.

Verschiedene Behandlungsmöglichkeiten werden in Umgebungszentrierte und Kindzentrierte Interventionen gegliedert und vorgestellt. Anhand eines Fallbeispiels wird ein mögliches Vorgehen in der Praxis aufgezeigt.
Unruhige Kinder und pflanzliche Sedativa
Authors: Dorsch Walter
Published: August 2017

Gesunde Kinder sind unruhig, aber die Toleranz gegenüber (unruhigen) Kindern ist sehr variabel, ebenso wie die Definition von „Unruhe“. Der behandelnde Arzt ist somit immer auch Familienarzt, der das System Familie systemisch mitbehandeln muss.

In der Behandlung unruhiger Kinder spielen pflanzliche Arzneimittel eine wichtige, aber nicht die erste Rolle. Synthetischen Arzneimitteln sind sie wegen ihres durchwegs günstigeren Nebenwirkungsprofils und ihrer schwächeren und deshalb besser steuerbaren Wirkung überlegen.

Was hilft unruhigen Kindern? Der Beitrag gibt einen Überblick über die wichtigsten pflanzlichen Sedativa und ihre Einsatzmöglichkeiten.
Ein Dauerbrenner bei Kindern
Authors: Friese Karl-Heinz
Published: August 2017

Die Otitis media kommt im Kindesalter sehr häufig vor, oft vergesellschaftet mit einem akuten Infekt der oberen Atemwege. Eine Antibiotika-Behandlung kann unter bestimmten Umständen notwendig sein, zum Beispiel, wenn sich die Symptome nicht nach 2–3 Tagen bessern. Eine homöopathische Erstbehandlung mit Aconitum napellus D 30 und anschließend Pulsatilla D 2 hilft bei etwa 80 % der Fälle.