bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical Expression on Stage and Screen
Authors: Connington Bill
Published: November 2017

A tight throat; held breath; stiff muscles; stage fright: impediments to performance come in many guises, but they all spring from the same source—tension.

In Physical Expression on Stage and Screen Bill Connington, a renowned teacher of the Alexander Technique, shows you how to recognize and release the tension that keeps you from performing at your best. If you’re ever not certain of what to do with your hands or how to make a meaningful gesture, or if your movement feels fine in daily life but then you suddenly become self-conscious when onstage or in front of a camera, this book is here to help.

More than one hundred clear, accessible exercises—including many filmed tutorials available online—will enable you to
Move more naturally and easilyBreathe more freelySpeak more clearlyFree your creative impulsesPlay a character with an unfamiliar physicality
Howard Barker’s Theatre
Authors: Reynolds James , Smith Andy W.
Published: November 2017

Howard Barker and The Wrestling School have been seen as marginal to the major concerns of British theatre, problematic in their staging and challenging in the ideas they explore. Yet Barker’s writing career spans six decades, he is the only living writer to have been accorded an entire season with the Royal Shakespeare Company, and The Wrestling School produces theatre of such a striking quality that it earned continuous Arts Council funding for nearly 20 years.

Wrestling with Catastrophe challenges existing ways of reading Barker’s theatre practice and plays and provides new ways into his work. The book brings together the full range of Barker’s aesthetic concerns – including text, direction, design, acting, narrative form, poetry, appropriation, painting, photography, electronic media, technology, puppetry, and theatre space – and in doing so, makes a radical re-evaluation possible.
Shakespeare’s Universality
Authors: Ryan Kiernan
Published: November 2017

Through close readings of a wide range of plays and poems, Kiernan Ryan’s compelling polemic sets out to reclaim the idea of Shakespeare’s timeless universality from reactionary and radical critics alike. Its argument is driven throughout by the belief that at this moment in history the need to recognise and activate the revolutionary potential of Shakespeare’s drama is more urgent than ever.
Applied Theatre: Research
Authors: O’Connor Peter , Anderson Michael
Published: November 2017

Applied Theatre as Research: Critical Departures will be the first book to consolidate thinking about applied theatre as research through a thorough investigation of ATAR as a research methodology. It will be an indispensible resource for teachers and researchers in the area. The first section of the book details the history of the relationship between applied theatre and research, especially in the area of evaluation and impact assessment. The relationship is problematized through an examination of the literature surrounding applied theatre and research. The book then explores how applied theatre as research (ATAR) works as a democratic and pro-social adjunct to community based research and explains its complex relationship to arts informed inquiry, Indigenous research methods and other research epistemologies. The book provides a rationale for this approach focusing on its capacity for reciprocity within communities. The second part of the book provides a series of international case studies of effective practice which details some of the key approaches in the method. The case studies provide a range of cultural contexts for the playing out of various forms of ATAR and a concluding chapter considers the tensions and the possibilities inherent in ATAR. This is a groundbreaking book for all researchers who are working with communities who require a method that moves beyond current research practice.
Stage Combat Arts
Authors: DuVal Christopher
Published: November 2017

The art of armed and unarmed stage combat thrills actors and audiences alike the world over. This book details many of the foundational techniques used by actors studying stage combat and actor-movement disciplines. A variety of specific training exercises are described that connect the actor’s imagination to a cohesive and meaningful actor-training curriculum – integrating stage combat with the actor’s process of developing a fully embodied awareness of the physical life of the character.

Developing physical awareness and dexterity is an essential component of an actor’s training and rehearsal processes. Engagement, connection, the ability to listen and respond with authenticity, clarity, flexibility, intentionality, tactical response, variety are all helpful aspects for the actor studying combat movement.

With practical exercises and expert advice, Stage Combat Arts allows the actor to further hone their emotional connection and extension, breath and voice, intention and focus, movement and freedom, and their ability to connect physically to imagery and text – disciplines that are at the foundation of actor-training – all through the art of combat movement.
Brecht on Theatre
Authors: Brecht Bertolt
Published: November 2017

Brecht on Theatre is a seminal work that has remained the classic text for readers and students wanting a rich appreciation of the development of Brecht’s thinking on theatre and aesthetics. First published in 1964 and on reading lists ever since, it has now been wholly revised, re-edited and expanded with additional texts, illustrations and editorial material, and new translations. The resulting work is a far fuller and more accurate volume that will provide readers with a clearer and more rewarding understanding of Brecht’s work and writings.

This updated third edition features:

* Clearer layout and organisation of the text to facilitate study

* New translations of many of the Brechtian texts featured

* Over 40 new, previously untranslated essays

* Essay titles now correspond to the German originals

* A revised selection of illustrations

This selection of Bertolt Brecht’s critical writing charts the development of his thinking on theatre and aesthetics over four decades. The volume demonstrates how the theories of Epic Theatre and Verfremdung evolved, and contains notes and essays on the staging of The Threepenny Opera,Mahagonny, Mother Courage, Puntila, Galileo and many others of his plays. Also included is ‘A Short Organon for the Theatre’, Brecht’s most complete statement of his revolutionary philosophy of the theatre.
The Theatre of Anthony Neilson
Authors: Reid Trish
Published: November 2017

Anthony Neilson is one of the most exciting and challenging voices in contemporary British theatre. For more than two decades he has been in the vanguard of new writing and has acquired a formidable reputation for innovation and experimentation. His major stage plays include Penetrator, The Censor, Stitching, Realism, Unreachable and his 2004 masterpiece The Wonderful World of Dissocia, arguably one of the finest Scottish plays of the new millennium.

This volume provides the first full-length study of Neilson's plays and his innovative rehearsal methodology. As well as providing a detailed account of each play Trish Reid includes an extensive new interview with Neilson and additional contributions from important scholars and commentators in the field. This is essential reading for anyone who wants to develop a better understanding of one of British theatre's most original artists.
The Theatre of D.H. Lawrence
Authors: Moran James
Published: November 2017

This is the first major book-length study for four decades to examine the plays written by D. H. Lawrence, and the first ever book to give an in-depth analysis of Lawrence’s interaction with the theatre industry during the early twentieth century. It connects and examines his performance texts, and explores his reaction to a wide-range of theatre (from the sensation dramas of working-class Eastwood to the ritual performances of the Pueblo people) in order to explain Lawrence’s contribution to modern drama.

F. R. Leavis influentially labelled the writer ‘D. H. Lawrence: Novelist’. But this book foregrounds Lawrence’s career as a playwright, exploring unfamiliar contexts and manuscripts, and drawing particular attention to his three most successful works: The Widowing of Mrs Holroyd, The Daughter-in-Law, and A Collier’s Friday Night. It examines how Lawrence’s novels are suffused with theatrical thinking, revealing how Lawrence’s fictions – from his first published work to the last story that he wrote before his death – continually take inspiration from the playhouse.

The book also argues that, although Lawrence has sometimes been dismissed as a restrictively naturalistic stage writer, his overall oeuvre shows a consistent concern with theatrical experiment, and manifests affinities with the dramatic thinking of modernist figures including Brecht, Artaud, and Joyce. In a final section, the book includes contributions from influential theatre-makers who have taken their own cue from Lawrence’s work, and who have created original work that consciously follows Lawrence in making working-class life central to the public forum of the theatre stage.
Applied Theatre: Facilitation
Authors: Preston Sheila
Published: November 2017

Applied Theatre: Facilitation is the first publication that directly explores the facilitator’s role within a range of socially engaged theatre and community theatre settings. The book offers a new theoretical framework for understanding critical facilitation in contemporary dilemmatic spaces and features a range of writings and provocations by international practitioners and experienced facilitators working in the field.

Part One offers an introduction to the concept, role and practice of facilitation and its applications in different contexts and cultural locations. It offers a conceptual framework through which to understand the idea of critical facilitation: a political practice that that involves a critical (and self-critical) approach to pedagogies, practices (doing and performing), and resilience in dilemmatic spaces. Part Two illuminates the diversity in the field of facilitation in applied theatre through offering multiple voices, case studies, theoretical positions and contexts. These are drawn from Australia, Serbia, Kyrgyzstan, India, Israel/Palestine, Rwanda, the United Kingdom and North America, and they apply a range of aesthetic forms: performance, process drama, forum, clowning and playmaking. Each chapter presents the challenge of facilitation in a range of cultural contexts with communities whose complex histories and experiences have led them to be disenfranchised socially, culturally and/or economically.
Theatre, Performance and Cognition
Authors: Blair Rhonda , Cook Amy
Published: November 2017

Theatre, Performance and Cognition introduces readers to the key debates, areas of research, and applications of the cognitive sciences to the humanities, and to theatre and performance in particular. It features the most exciting work being done at the intersection of theatre and cognitive science, containing both selected scientific studies that have been influential in the field, each introduced and contextualised by the editors, together with related scholarship from the field of theatre and performance that demonstrates some of the applications of the cognitive sciences to actor training, the rehearsal room and the realm of performance more generally.

The three sections consider the principal areas of research and application in this interdisciplinary field, starting with a focus on language and meaning-making in which Shakespeare's work and Tom Stoppard's Arcadia are considered. In the second part which focuses on the body, chapters consider applications for actor and dance training, while the third part focuses on dynamic ecologies, of which the body is a part.
Performing King Lear
Authors: Croall Jonathan
Published: November 2017

King Lear is arguably the most complex and demanding play in the whole of Shakespeare. Once thought impossible to stage, today it is performed with increasing frequency, both in Britain and America. It has been staged more often in the last fifty years than in the previous 350 years of its performance history, its bleak message clearly chiming in with the growing harshness, cruelty and violence of the modern world.

Performing King Lear offers a very different and practical perspective from most studies of the play, being centred firmly on the reality of creation and performance. The book is based on Jonathan Croall’s unique interviews with twenty of the most distinguished actors to have undertaken this daunting role during the last forty years, including Donald Sinden, Tim Pigott-Smith, Timothy West, Julian Glover, Oliver Ford Davies, Derek Jacobi, Christopher Plummer, Michael Pennington, Brian Cox and Simon Russell Beale.

He has also talked to two dozen leading directors who have staged the play in London, Stratford and elsewhere. Among them are Nicholas Hytner, David Hare, Kenneth Branagh, Adrian Noble, Deborah Warner, Jonathan Miller and Dominic Dromgoole. Each reveals in precise and absorbing detail how they have dealt with the formidable challenge of interpreting and staging Shakespeare’s great tragedy.
A Taste of Honey GCSE Student Guide
Authors: Whittaker Kate
Published: November 2017

Written specifically for GCSE students by academics and specialists in the field, the Methuen Drama GCSE Student Guides conveniently gather indispensable resources and tips for successful understanding and writing all in one place, preparing students to approach their exams with confidence.

Key features include a critical commentary of the play with extensive, clearly labelled analyses on themes, characters and context. They take studying drama even further with sections on dramatic technique, critical reception, related works, fascinating behind-the-scenes interviews with playwrights, directors or actors, and a helpful glossary of dramatic terms.

Shelagh Delaney’s modern classic A Taste of Honey is a comic and poignant exploration of class, feminism, race, sexual orientation and optimism in post-war Britain. Fifty years after its hit premiere, working-class Lancashire lass Jo’s story continues to engage new generations of audiences.

Closely following the requirements of GCSE English Literature assessment objectives, these studies include expert advice on how to write about modern drama. With featured activities for group study and independent work, they are versatile and valuable to students and teachers alike.
Steppenwolf Theatre Company of Chicago
Authors: Mayer John
Published: November 2017

In 1974, a group of determined, young high school actors started doing plays under the name of Steppenwolf Theatre Company, eventually taking residence in the basement of a church in Highland Park, a suburb of Chicago. Thus began their unlikely journey to become one of the most prominent theatre companies in the world.

Steppenwolf Theatre Company has changed the face of American Theatre with its innovative approach that blends dynamic ensemble performance, honest, straightforward acting, and bold, thought-provoking stories to create compelling theatre.

This is the first book to chronicle this iconic theatre company, offering an account of its early years and development, its work, and the methodologies that have made it one of the most influential ensemble theatres today.

Through extensive, in-depth interviews conducted by the author with ensemble members, this book reveals the story of Steppenwolf’s miraculous rise from basement to Broadway and beyond. Interviewees include co-founders Jeff Perry, Gary Sinise and Terry Kinney, along a myriad of ensemble, staff, board members and others.
Cracking Shakespeare
Authors: Hunter Kelly
Published: November 2017

Cracking Shakespeare serves to demystify the process of speaking Shakespeare’s language, offering hands-on techniques for drama students, young actors and directors who are intimidated by rehearsing, performing and directing Shakespeare’s plays.

For some artists approaching Shakespeare, the ability to capture the dynamic movement of thought from mind to mouth, and the paradox of using the formality of verse to express a realistic form of speech, can seem daunting. Cracking Shakespeare includes practical techniques and exercises to solve this dilemma – including supporting online video which demonstrate how to embody Shakespeare’s characters in rehearsal and performance – offering a toolkit that will free actors and directors from their fear of Shakespeare.

The result of thirty years of acting, teaching and directing Shakespeare, Kelly Hunter’s Cracking Shakespeare is the ideal textbook for actors and directors looking for new ways to approach Shakespeare’s plays in a hands-on, down-to-earth style.
My Mother Said I Never Should GCSE Student Guide
Authors: Bush Sophie
Published: November 2017

Written specifically for GCSE students by academics in the field, the Methuen Drama GCSE Guides conveniently gather indispensable resources and tips for successful understanding and writing all in one place, preparing students to approach their exams with confidence.

Key features include a critical commentary of the play with extensive, clearly labelled analyses on themes, characters and context. They take studying drama even further with sections on dramatic technique, critical reception, related works, fascinating behind-the-scenes interviews with playwrights, directors or actors, and a helpful glossary of dramatic terms.

Charlotte Keatley's My Mother Said I Never Should grapples with social forces that threaten to split four generations of women apart. When Jackie, who is unmarried, gives away her baby to her mother, the women are united in keeping this family secret yet divided in their opinions of it.

Closely following the requirements of GCSE English Literature assessment objectives, these studies include expert advice on how to write about modern drama. With featured activities for group study and independent work, they are versatile and valuable to students and teachers alike.
Shakespeare’s Medical Language
Authors: Iyengar Sujata
Published: November 2017

Physicians, readers and scholars have long been fascinated by Shakespeare's medical language and the presence or mentioning of healers, wise women, surgeons and doctors in his work. This dictionary includes ailments, general medical concepts (elements, humours, spirits) and cures and therapies (ranging from blood-letting to herbal medicines) in Shakespeare, but also body parts, bodily functions, and entries on 'the pathological body' taking into account recent critical work on the early modern body. It will provide a comprehensive guide for those needing to understand specific references in the plays, in particular, archaic diagnoses or therapies ('choleric', 'tub-fast') and words that have changed their meanings ('phlegmatic', 'urinal'); those who want to learn more about early modern medical concepts ('elements', 'humors'); and those who might have questions about the embodied experience of living in Shakespeare's England. Entries reveal what terms and concepts might mean in the context of Shakespeare's plays, and the significance that a particular disease, body part or function has in individual plays and the Shakespearean corpus at large.
Berlioz, Verdi, Wagner, Britten
Authors: Albright Daniel
Published: November 2017

Great Shakespeareans offers a systematic account of those figures who have had the greatest influence on the interpretation, understanding and cultural reception of Shakespeare, both nationally and internationally.

In this volume, leading scholars assess the contribution of Berlioz, Verdi, Wagner and Britten to the afterlife and reception of Shakespeare and his plays. Each substantial contribution assesses the double impact of Shakespeare on the figure covered and of the figure on the understanding, interpretation and appreciation of Shakespeare, provide a sketch of their subject's intellectual and professional biography and an account of the wider cultural context, including comparison with other figures or works within the same field.
Seasonal variation and chemical characterization of PM2.5
in northwestern Philippines
Authors: Bagtasa Gerry , Cayetano Mylene G. , Yuan Chung-Shin
Published: November 2017

Abstract. The seasonal and chemical characteristic of fine particulate matter (PM2.5) was investigated in Burgos, Ilocos Norte, located at the northwestern edge of the Philippines. Each 24H-sample of fine aerosol was collected for two weeks every season. Fine particulate in the region shows strong seasonal variation in both concentration and composition. Highest mass concentration was seen during the boreal spring season with a mean mass concentration of 21.59 μg m-3, and lowest was in fall with a mean concentration of 8.44 μg m-3. Three-day wind back trajectory analysis of air mass reveals the influence of the North Western Pacific monsoon regimes on PM2.5 concentration. During southwest monsoon, sea salt is the dominant component of fine aerosols carried by moist air from the South China Sea. During northeast monsoon, on the other hand, both wind and receptor model (USEPA PMF) analysis showed that higher particulate concentration was due to the Long Range Transport (LRT) of anthropogenic emissions from the northern East Asia. Overall, sea salt and soil comprise 33 % of total PM2.5 concentration while local biomass burning makes up 33 %. LRT of industrial emission, solid waste burning and secondary sulfate from East Asia have a mean contribution of 34 % to the total fine particulate for the whole sampling period.
Assessment of inter-city transport of particulate matter in the Beijing-Tianjin-Hebei region
Authors: Chang Xing , Wang Shuxiao , Zhao Bin , Cai Siyi , Hao Jiming
Published: November 2017

Abstract. The regional transport of PM2.5 plays an important role in the air quality over the Beijing-Tianjin-Hebei (BTH) region in China. However, previous studies on regional transport of PM2.5 are mainly at province level, which is insufficient for the development of an optimal joint PM2.5 control strategy. In this study, we calculate PM2.5 inflows and outflows through the administrative boundaries of three major cities in the BTH region, i.e. Beijing, Tianjin and Shijiazhuang, using the WRF (Weather Research and Forecasting model) – CMAQ (Community Multiscale Air Quality) modelling system. The monthly average inflow fluxes indicate the major directions of PM2.5 transport. For Beijing, the PM2.5 inflow fluxes from Zhangjiakou (on the northwest) and Baoding (on the southwest) constitute 57 % of the total in winter, and Langfang (on the southeast) and Baoding constitute 73 % in summer. Based on the net PM2.5 fluxes and their vertical distributions, we find there are three major transport pathways in the BTH region: the Northwest-Southeast pathway in winter (at all levels below 1000 m), the Southeast-Northwest pathway in summer (at all levels below 1000 m), and the Southwest-Northeast pathway both in winter and in summer (mainly at 400–1000 m). In winter, even if surface wind speeds are small, the transport at above 400 m could still be strong. Among the three pathways, the Southwest-Northeast happens along with PM2.5 concentrations 30 % and 55 % higher than the monthly average in winter and summer, respectively. Analysis of two heavy pollution episodes in January and July in Beijing show a much stronger (8–16 times) transport than the monthly average, emphasizing the joint air pollution control of the cities located on the transport pathways, especially during heavy pollution episodes.
Mercury distribution and transport in the North Atlantic Ocean along the GEOTRACES-GA01 transect
Authors: Cossa Daniel , Heimbürger Lars-Eric , Pérez Fiz F. , García-Ibáñez Maribel I. , Sonke Jeroen E. , Planquette Hélène , Lherminier Pascale , Sarthou Géraldine
Published: November 2017

Abstract. We report here the results of total mercury (HgT) determinations along the 2014 GEOTRACES GEOVIDE cruise (GA01 transect) in the North Atlantic Ocean (NA) from Lisbon (Portugal) to the Labrador coast (Canada). Ninety-seven percent of the HgT concentrations of unfiltered samples (HgTUNF) ranged between 0.16 and 1.00 pmol L−1. The geometric mean was 0.51 pmol L−1 for the 535 samples analysed. The dissolved fraction (
On the Effect of Model Parameters on Forecast Objects
Authors: Marzban Caren , Jones Corinne , Li Ning , Sandgathe Scott
Published: November 2017

Abstract. Many physics-based numerical models produce a gridded, spatial field of forecasts, e.g., a temperature "map". However, the field for some quantities such as precipitation generally consists of spatially coherent and disconnected "objects". Certain features of these objects (e.g., number, size, and intensity) are generally of interest. Here, a methodology is developed for assessing the impact of model parameters on features of forecast objects. Although, in principle, the objects can be defined by any means, here they are identified via clustering algorithms. The methodology is demonstrated on precipitation forecasts from a mesoscale numerical weather prediction model.
Combining temporal 3D remote sensing data with spatial rockfall
simulations for improved understanding of hazardous slopes within
rail corridors
Authors: van Veen Megan , Hutchinson D. Jean , Bonneau David A. , Sala Zac , Ondercin Matthew , Lato Matt
Published: November 2017

Abstract. Remote sensing techniques can be used to gain a more detailed understanding of hazardous rock slopes along railway corridors that would otherwise be inaccessible. Multiple datasets can be used to identify changes over time and create an inventory of rockfall events including frequency-magnitude relationships for rockfalls sourced on the slope. This study presents a method for using the remotely sensed data to develop inputs to rockfall simulations, which can be used to determine the likelihood of a rockfall impacting the railway tracks given it’s source zone location and volume. The results of the simulations can be related to the rockfall inventory to develop modified frequency-magnitude curves presenting a more realistic estimate of the hazard. These methods were developed using the RockyFor3D software and LiDAR and photogrammetry data collected over several years at the White Canyon, British Columbia, Canada, where the CN Rail main line runs along the base of the slope. Rockfalls sourced closer to the tracks were more likely to be deposited on the track or in the ditch, and of these, rockfalls between 0.1 and 10 m3 were the most likely to be deposited. Smaller blocks did not travel far enough to reach the bottom of the slope and larger blocks were deposited past the tracks. Applying the results of the simulations to a database of over 2000 rockfall events, a modified frequency-magnitude can be created, allowing the frequency of rock falls deposited on the railway tracks or in ditches to be determined. Suggestions are made for future development of the methods including refinement of input parameters and extension to other modelling packages.
Los comunales en el Pirineo Central. Idealizando el pasado y reelaborando el presente
Authors: Beltran Oriol , Vaccaro Ismael
Published: November 2017

El debate en torno a los comunales ha estado a menudo protagonizado por posiciones ideológicas acerca de sus implicaciones sociales, económicas, ambientales y políticas. Las comarcas del Alto Pirineo en Cataluña, donde la propiedad comunal ha tenido una gran representación territorial y una larga continuidad en el tiempo, ofrecen numerosos argumentos para situar esta discusión en unos parámetros más realistas. En el contexto de los cambios registrados en los últimos dos siglos, donde el territorio de la montaña ha pasado de proveer los recursos necesarios en una economía agropecuaria a devenir un espacio destinado al turismo y la conservación, los bienes comunales son interpretados como una dimensión central de las relaciones ambientales a la vez que como un rasgo de un gran potencial político.
Corrosion of Titanium: Part 1: Aggressive Environments and Main Forms of Degradation
Authors: Prando Davide , Brenna Andrea , Diamanti Maria Vittoria , Beretta Silvia , Bolzoni Fabio , Ormellese Marco , Pedeferri MariaPia
Published: November 2017

Titanium has outstanding corrosion resistance due to the external natural oxide protective layer formed when it is exposed to an aerated environment. Despite this, titanium may suffer different forms of corrosion in severe environments: uniform corrosion, pitting and crevice corrosion, hydrogen embrittlement, stress-corrosion cracking, fretting corrosion and erosion. In this first review, forms of corrosion affecting titanium are analyzed based on a wide literature review. For each form of corrosion, the mechanism and most severe environment are reported according to the current understanding.

In the second part, this review will address the possible surface treatments that can increase corrosion resistance on commercially pure titanium: Electrochemical anodizing, thermal oxidation, chemical oxidation and bulk treatments such as alloying will be considered, highlighting the advantages of each technique.
Evaluation of Parasite Egg and Cyst Recovery Using Devices Designed for Centrifugal or Stationary Flotation
Authors: Medeiros Kelsea L. , Lucio-Forster Araceli , Bowman Dwight Douglas
Published: November 2017

Two new devices (OT, ST), were recently introduced for the recovery of parasite eggs and cysts for microscopic examination. These devices, two stationary flotation devices, and a standard double-centrifugal sugar-flotation were compared using common flotation solutions and methods recommended by the manufacturers for the recovery of hookworm, ascaridoid, and whipworm eggs from companion animal fecal samples. Additionally, the recovery of Giardia cysts in the OT device using a zinc sulfate versus sodium nitrate solution was evaluated. Double-centrifugal sugar-flotation (1.30 specific gravity) was the most sensitive method for the recovery of the nematode eggs from feces of companion animals. Overall, centrifugation increased the recovery of eggs as compared with standing flotation methods, with the ST performing equivalently to the OT. Although these more recently introduced tests have good sensitivities for the nematodes tested, egg recovery was routinely markedly less than that achieved by standard double-centrifugal sugar-flotation, and false-negatives did occur. Still, the OT and ST generally have increased recoveries over the two standing flotation devices, and are significantly better than these for the recovery of ascaridoid and whipworm eggs from dog and cat samples. Zinc sulfate (1.18 specific gravity) is recommended for the recovery of Giardia cysts when using the OT device.
Microfinance Institutions in Kosovo Regulation and Supervision Issues and Challenges
Authors: Zeqiraj Veton , Murati Fitor , Zeqiraj Valon
Published: November 2017

We examine the need for regulatory reform of Microfinance Institutions (MFIs) in Kosovo. On its substance, this paper highlights the prevailing importance of a regulatory reform that enables transformation of MFIs incorporated as Non-Governmental Organizations (NGOs) to Joint Stock Companies (JSC) and the respective implications. In doing so, the paper highlights a wide range of challenging issues related to the regulation and supervision of MFIs with careful reflections carried out and strategic decisions considered. Intrinsic and extrinsic challenging issues are investigated in the context of local market settings and circumstances with a great deal of consideration of international standards and best practices on regulation and supervision of MFIs.
STUDY OF THE LINKS BETWEEN THE DEVELOPMENT OF THE WORLD ECONOMY AND TRANSPORT IN 1995–2015
Authors: Mindur Maciej
Published: November 2017

The article provides a synthetic analysis of the interrelationships between economic development, the primary economic measure of which is the size of Gross Domestic Product, and the volume of transport work measured in tkm and pkm. The study was conducted over a 30-year time series based on the polynomial curves of the most-developed economies (the United States, Japan, China and EU-28) and Russia, the largest area of the world, with large natural resources and significant military industry, and constantly increasing since 2004 GDP. The research shows that GDP in the whole period (1995–2015) in the United States, Japan and the European Union is growing rapidly, significantly ahead of the tkm and pkm transport indicators. In China and Russia, GDP growth has been increasing since 2003, while the dynamic growth of transport (in billion tkm) in 1995–2015 is well ahead of economic growth (GDP). In Poland, trends in the development of the GDP measurement and transport indicators (tkm and pkm) are similar to those of Russia and China.
NEW PRODUCT INTRODUCTION PHASE IN RELATION TO SUPPLY CHAIN PLANNING PROCESSES
Authors: Krzemińska Alicja
Published: November 2017

The article presents the role and importance of sharing information about new product implementation by sales, marketing and R&D departments with supply chain part of the organization. In the introduction has been showed conventional attitude to the new product development phase. Then has been presented modern collaborative approach which allows to include new products in short-term and long-term plans of the company. Next, a detailed, theoretical and practical characterization of planning processes has been made with products being taken into account which become the part of a finished goods portfolio. Then, basing on examples taken from FMCG company the long term results of not including new products in plans on time have been shown. To conclude, a short summary has been made.
Magnusiomyces capitatus: a new and emerging pathogen linked to keratomycosis
Authors: Shah Ankit , Mauger Thomas
Published: November 2017

We describe our experience managing a case of fungal keratitis in a 71-year-old immunocompetent woman. Intracameral cultures isolated Magnusiomyces capitatus, a dimorphic commensal microbe with limited pathogenicity, in an immune competent patient. Repeated corneal cultures for bacteria and fungus were negative. Initial broad-spectrum topical fortified antibiotics were eventually escalated to include topical natamycin and voriconazole and oral voriconazole. The patient underwent emergent corneal transplantation, but recurrent infection eventually required anterior chamber washout and intracameral injection of amphotericin B. A combination of topical, systemic, intracameral administration of voriconazole, intracameral administration of amphotericin B, anterior chamber washout, and penetrating keratoplasty were required to clear the infection.
Systematic approaches for reviewing neuro-imaging scans in ophthalmology
Authors: Kruger Joshua M. , Cestari Dean M. , Cunnane Mary Beth
Published: November 2017

Neuroimaging is an important tool in ophthalmology, but many ophthalmologists are uncomfortable evaluating actual scans. Unfortunately, exclusive reliance on a radiologist’s report can lead to diagnostic and management errors. We outline a methodology for equipping ophthalmologists with the skills necessary to read neuroimaging studies with respect to specific clinical questions.
Left, Right, Left, Right... Centre: Ideological Position of Andrej Babiš’s ANO
Authors: Hájek Lukáš
Published: November 2017

The paper deals with the ideological position of a newly formed business-firm party called ANO in the contemporary political environment of the Czech Republic. Although the advent of the party was truly rapid and ANO is a fairly unique formation, it is possible to employ some conventional analytical tools to reveal the party’s ideological position. Firstly, I show that ANO is a vote-seeking party and it is therefore possible to analyse it in accordance with a Downsian spatial modelling. Next, I describe a roll call analysis method that is able to objectively identify the party’s ideological position based on legislators’ parliamentary votes. After I form several hypotheses, a data set consisting of 8,559 roll calls of 215 members of the Chamber of Deputies is depicted. Finally, the results show that ANO is located in the ideological centre, closer to social democrats rather than to right-wing parties. Besides this, ANO covers a smaller ideological space compared to traditional political parties. Finally, the results do not anticipate a potential split of ANO in the near future since the party’s legislators have acted cohesively in the parliament so far.
Why Not Capitalism?
Authors: Návrat Miroslav
Published: November 2017

Brennan, Jason (2014). Why Not Capitalism? New York: Routledge, 120 pages.
Responsabilidade penal ambiental da pessoa jurídica na visão do Supremo Tribunal Federal: uma análise do RE 548181/PR
Authors: Costa Beatriz , Marotta Clarice Gomes
Published: November 2017

A preocupação básica deste artigo é refletir sobre a aplicação da opção política criminal brasileira de responsabilizar penalmente a pessoa jurídica por crimes ambientais, através do estudo das decisões emanadas pelos Tribunais Superiores em relação ao tema e, especialmente, da decisão prolatada no Recurso Extraordinário n. 548181/ PR, adotada como marco teórico. Para tanto, empregamos o método dedutivo, com utilização da técnica de pesquisa documental – aos sítios dos tribunais – e bibliográfica, considerando-se as contribuições de autores consagrados da doutrina nacional. Concluímos que o Judiciário vem se adaptando para dar efetividade à decisão do legislador brasileiro, especialmente ao superar a teoria da dupla imputação. Por outro lado, há divergências acerca da compatibilidade ou não da responsabilização de empresas com a dogmática penal, em especial no que se refere à conduta (dolo e culpa), à culpabilidade e à pena, que exigem aprofundamento nos estudos sobre o tema, com a construção de uma teoria do crime voltada especialmente às pessoas jurídicas.
Planejamento social na Administração Pública: um instrumento essencial na promoção dos direitos fundamentais sociais
Authors: Silva Melo de Casimiro Ligia Maria , Moraes Filomeno
Published: November 2017

O presente artigo trata do papel do planejamento como instrumento de promoção do acesso aos direitos fundamentais, observando e realizando as previsões constitucionais sobre os objetivos do Estado Democrático e Social brasileiro. A análise passa pela descrição do histórico de uso do instrumento pelo Estado brasileiro antes da Constituição de 1988, apresentando uma leitura do papel do planejamento nos programas econômicos entre 1950 e 1988, e demonstrar a necessidade de avanço na seara da gestão pública em si. Defende-se a necessidade da institucionalização do planejamento como meio de controle da ação pública, destacando sua funcionalidade para auxiliar na atuação de uma gestão pública e democrática que tenha o compromisso com a eficiência e a eficácia de ações, garantindo o desenvolvimento humano a partir da efetividade dos direitos fundamentais. Aborda-se, especialmente, a construção da ação de planejar observando os valores democráticos com a previsão da participação popular nas decisões que envolvem a definição de políticas públicas, custos e recursos. A cultura dialógica da Administração com relação à sociedade pode ser amparada substancialmente pelo reconhecimento do planejamento como ferramenta institucional, para além da questão orçamentária, pelo Direito Administrativo, como um instituto a compor o regime jurídico que baliza a Administração Pública brasileira.
КВАЛИТЕТ ВОДЕ АКУМУЛАЦИОНОГ ЈЕЗЕРА ДРЕНОВА
Authors: Пешевић Душица , Марковић Наташа
Published: November 2017

Вода из акумулације Дренова, која се користи за водоснабдијевање града Прњавора иприградских насеља, под забраном je употребе за пиће од 2003. године. Циљ рада је да се утврдепотенцијални загађивачи наведеног подручја, као и процјена погодности воде заводоснабдијевање. На основу добијених резултата физичко-хемијских и микробиолошкиханализа, дат је преглед стања квалитета воде акумулационог језера Дренова у периоду 2011–2013.година и у периоду 2015–2016. годинe. Са аспекта физичко-хемијских и микробиолошкихиспитивања, квалитет воде акумулације није на задовољавајућем нивоу. Најчешћи параметрифизичко-хемијске неисправности су повећане концентрације гвожђа, мангана, олова,алуминијума, амонијака, нитрата, нитрита, као и повећан утрошак калијум-перманганата.Најчешћи узрочници микробиолошке неисправности су укупне колиформне бактерије, укупнеаеробне мезофилне бактерије, стрептококе фекалног поријекла, сулфиторедукујуће клостридије иентерококе. У септембру 2013. године и септембру и децембру 2015. године забиљежено јеприсуство пестицида.
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data
Authors: Racle Julien , de Jonge Kaat , Baumgaertner Petra , Speiser Daniel E , Gfeller David
Published: November 2017

Immune cells infiltrating tumors can have important impact on tumor progression and response to therapy. We present an efficient algorithm to simultaneously estimate the fraction of cancer and immune cell types from bulk tumor gene expression data. Our method integrates novel gene expression profiles from each major non-malignant cell type found in tumors, renormalization based on cell-type-specific mRNA content, and the ability to consider uncharacterized and possibly highly variable cell types. Feasibility is demonstrated by validation with flow cytometry, immunohistochemistry and single-cell RNA-Seq analyses of human melanoma and colorectal tumor specimens. Altogether, our work not only improves accuracy but also broadens the scope of absolute cell fraction predictions from tumor gene expression data, and provides a unique novel experimental benchmark for immunogenomics analyses in cancer research (http://epic.gfellerlab.org).
Assessing Mongolian gerbil emotional behavior: effects of two shock intensities and response-independent shocks during an extended inhibitory-avoidance task
Authors: Hurtado-Parrado Camilo , González-León Camilo , Arias-Higuera Mónica A. , Cardona Angelo , Medina Lucia G. , García-Muñoz Laura , Sánchez Christian , Cifuentes Julián , Forigua Juan Carlos , Ortiz Andrea , Acevedo-Triana Cesar A. , Rico Javier L.
Published: November 2017

Despite step-down inhibitory avoidance procedures that have been widely implemented in rats and mice to study learning and emotion phenomena, performance of other species in these tasks has received less attention. The case of the Mongolian gerbil is of relevance considering the discrepancies in the parameters of the step-down protocols implemented, especially the wide range of foot-shock intensities (i.e., 0.4–4.0 mA), and the lack of information on long-term performance, extinction effects, and behavioral patterning during these tasks. Experiment 1 aimed to (a) characterize gerbils’ acquisition, extinction, and steady-state performance during a multisession (i.e., extended) step-down protocol adapted for implementation in a commercially-available behavioral package (Video Fear Conditioning System—MED Associates Fairfax, VT, USA), and (b) compare gerbils’ performance in this task with two shock intensities – 0.5 vs. 1.0 mA—considered in the low-to-mid range. Results indicated that the 1.0 mA protocol produced more reliable and clear evidence of avoidance learning, extinction, and reacquisition in terms of increments in freezing and on-platform time as well as suppression of platform descent. Experiment 2 aimed to (a) assess whether an alternate protocol consisting of a random delivery of foot shocks could replicate the effects of Experiment 1 and (b) characterize gerbils’ exploratory behavior during the step-down task (jumping, digging, rearing, and probing). Random shocks did not reproduce the effects observed with the first protocol. The data also indicated that a change from random to response-dependent shocks affects (a) the length of each visit to the platform, but not the frequency of platform descends or freezing time, and (b) the patterns of exploratory behavior, namely, suppression of digging and rearing, as well as increments in probing and jumping. Overall, the study demonstrated the feasibility of the extended step-down protocol for studying steady performance, extinction, and reacquisition of avoidance behavior in gerbils, which could be easily implemented in a commercially available system. The observation that 1.0 mA shocks produced a clear and consistent avoidance behavior suggests that implementation of higher intensities is unnecessary for reproducing aversive-conditioning effects in this species. The observed patterning of freezing, platform descents, and exploratory responses produced by the change from random to periodic shocks may relate to the active defensive system of the gerbil. Of special interest is the probing behavior, which could be interpreted as risk assessment and has not been reported in other rodent species exposed to step-down and similar tasks.
Generation and characterization of cross neutralizing human monoclonal antibody against 4 serotypes of dengue virus without enhancing activity
Authors: Injampa Subenya , Muenngern Nataya , Pipattanaboon Chonlatip , Benjathummarak Surachet , Boonha Khwanchit , Hananantachai Hathairad , Wongwit Waranya , Ramasoota Pongrama , Pitaksajjakul Pannamthip
Published: November 2017

Background

Dengue disease is a leading cause of illness and death in the tropics and subtropics. Most severe cases occur among patients secondarily infected with a different dengue virus (DENV) serotype compared with that from the first infection, resulting in antibody-dependent enhancement activity (ADE). Our previous study generated the neutralizing human monoclonal antibody, D23-1B3B9 (B3B9), targeting the first domain II of E protein, which showed strong neutralizing activity (NT) against all four DENV serotypes. However, at sub-neutralizing concentrations, it showed ADE activityin vitro.

Methods

In this study, we constructed a new expression plasmid using the existing IgG heavy chain plasmid as a template for Fc modification at position N297Q by site-directed mutagenesis. The resulting plasmid was then co-transfected with a light chain plasmid to produce full recombinant IgG (rIgG) in mammalian cells (N297Q-B3B9). This rIgG was characterized for neutralizing and enhancing activity by using different FcγR bearing cells. To produce sufficient quantities of B3B9 rIgG for further characterization, CHO-K1 cells stably secreting N297Q-B3B9 rIgG were then established.

Results

The generated N297Q-B3B9 rIgG which targets the conserved N-terminal fusion loop of DENV envelope protein showed the same cross-neutralizing activity to all four DENV serotypes as those of wild type rIgG. In both FcγRI- and RII-bearing THP-1 cells and FcγRII-bearing K562 cells, N297Q-B3B9 rIgG lacked ADE activity against all DENV serotypes at sub-neutralizing concentrations. Fortunately, the N297Q-B3B9 rIgG secreted from stable cells showed the same patterns of NT and ADE activities as those of the N297Q-B3B9 rIgG obtained from transient expression against DENV2. Thus, the CHO-K1 stably expressing N297Q-B3B9 HuMAb can be developed as high producer stable cells and used to produce sufficient amounts of antibody for further characterization as a promising dengue therapeutic candidate.

Discussion

Human monoclonal antibody, targeted to fusion loop of envelope domainII (EDII), was generated and showed cross-neutralizing activity to 4 serotypes of DENV, but did not cause any viral enhancement activityin vitro. This HuMAb could be further developed as therapeutic candidates.