bluuebunny/crossref_metadata_2025 huggingface dataset:
High Throughput Isolation and Data Independent Acquisition Mass Spectrometry (DIA-MS) of Urinary Extracellular Vesicles to Improve Prostate Cancer Diagnosis
Authors: Zhang Hao , Zhang Gui-Yuan , Su Wei-Chao , Chen Ya-Ting , Liu Yu-Feng , Wei Dong , Zhang Yan-Xi , Tang Qiu-Yi , Liu Yu-Xiang , Wang Shi-Zhi , Li Wen-Chao , Wesselius Anke , Zeegers Maurice P. , Zhang Zi-Yu , Gu Yan-Hong , Tao W. Andy , Yu Evan Yi-Wen
Published: November 2022

Proteomic profiling of extracellular vesicles (EVs) represents a promising approach for early detection and therapeutic monitoring of diseases such as cancer. The focus of this study was to apply robust EV isolation and subsequent data-independent acquisition mass spectrometry (DIA-MS) for urinary EV proteomics of prostate cancer and prostate inflammation patients. Urinary EVs were isolated by functionalized magnetic beads through chemical affinity on an automatic station, and EV proteins were analyzed by integrating three library-base analyses (Direct-DIA, GPF-DIA, and Fractionated DDA-base DIA) to improve the coverage and quantitation. We assessed the levels of urinary EV-associated proteins based on 40 samples consisting of 20 cases and 20 controls, where 18 EV proteins were identified to be differentiated in prostate cancer outcome, of which three (i.e., SERPINA3, LRG1, and SCGB3A1) were shown to be consistently upregulated. We also observed 6 out of the 18 (33%) EV proteins that had been developed as drug targets, while some of them showed protein-protein interactions. Moreover, the potential mechanistic pathways of 18 significantly different EV proteins were enriched in metabolic, immune, and inflammatory activities. These results showed consistency in an independent cohort with 20 participants. Using a random forest algorithm for classification assessment, including the identified EV proteins, we found that SERPINA3, LRG1, or SCGB3A1 add predictable value in addition to age, prostate size, body mass index (BMI), and prostate-specific antigen (PSA). In summary, the current study demonstrates a translational workflow to identify EV proteins as molecular markers to improve the clinical diagnosis of prostate cancer.
Asperphenyltones A and B: New Phenylfuropyridinone Skeleton from an Endophytic Aspergillus sp. GXNU-A1
Authors: Huang Jiguo , Bo Xianglong , Wu Furong , Tan Meijing , Wei Youquan , Wang Lixia , Zhou Junqiang , Wu Guiming , Huang Xishan
Published: November 2022

Chemical investigation of the fermentation extract of the mangrove endophytic fungus Aspergillus sp. GXNU-A1, isolated from Acanthus ilicifolius L., discovered an undescribed pair of enantiomers (asperphenyltones A and B (±1)), together with four previously described metabolites: nodulisporol (2), isosclerone (3), 2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzyl alcohol (4), and 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (5). Analyses of the 1D and 2D NMR spectroscopic data of the compounds supported their structural assignments. The presence of the asperphenyltones A and B, which are a pair of enantiomers, was established by HR-ESI-MS, 1D and 2D NMR data and confirmed by single-crystal X-ray diffraction analysis. Metabolites 1–5 were evaluated for their anti-inflammatory effects on the production of nitric oxide (NO), and 1, 3, and 4 showed significant potential inhibitory activities against NO production in activated macrophages with IC50 values of 26–40 μM, respectively.
Research on Optical and Mechanical Compatible Design Technology of Multilayer Films
Authors: Bai Jinlin , Liu Huasong , Li Ziyang , Sun Peng , Yang Xiao , Li Shida , Su Jianzhong
Published: November 2022

The stress’s accumulation will critically affect optical device stability, leading to components’ deviation and film peeling. Stress control techniques based on strain cancelation cannot precisely match film stress, and it is difficult to reduce the total stress of multilayer film to ultra-low levels. Existing software for film system design is mainly based on 2D design concepts such as wavelength-spectrum and does not consider 3D design concepts such as wavelength-spectrum-stress, but the stress parameter plays an essential role in film performance, and it is necessary to use it as an optimization index for film design. In this paper, we introduce mechanical synchronization design into film system design. The multilayer film’s optimal structure is precisely matched by the genetic algorithm, and an ultra-low stress and wide-spectrum optical film element is developed under the dual requirements of optical performance and mechanical performance. This technique incorporates computer-aided design and automatically seeks an optimal combination of layered film nanostructures through self-compiled optical and mechanical compatible design software. While ensuring invariant optical properties, it can effectively reduce the total stress of multilayer film. This can provide a new idea for film stress control.
Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis
Authors: Pugliese Michela , La Maestra Rocky , Ragusa Monica , Or Mehmet Erman , Merola Giordana , Napoli Ettore , Passantino Annamaria
Published: November 2022

Several studies performed in humans have demonstrated that the onset of systemic inflammatory response syndrome (SIRS) represents a high risk condition to develop myocardial damage and arrhythmias. Therefore, we also hypothesized cardiac involment for dogs affected by SIRS. To assess this hypothesis, 24 dogs with a diagnosis of SIRS (13 entire males, 7 entire females, and 4 spayed females) with an age ranging from 4 to 11 years (mean 5.6 years) and an average weight of 24 kg (range from 5 to 47 kg) were enrolled. The dogs were divided into two groups according to their prognosis: Survivors (G1) and not survivors (G2), composed by 13 and 11 dogs, respectively. Moreover, healthy dogs were included as the control group (CTR). All the dogs with a history of cardiac or renal disease were excluded. At the inclusion, each patient underwent a physical examination and a complete cell count, and a biochemistry panel (including electrolyte profile) was performed; moreover, the blood cardiac Troponin I (cTnI) was measured. For each clinical variable indicative of SIRS, a score between 0 (absence) and 1 (presence) was applied. Furthermore, an electrocardiographic examination was recorded. Seventeen out of 24 (70.8%) dogs with SIRS showed arrhythmias, of which n. 6 belonged to the G1, while n. 11 belonged to the G2. Most represented findings were sinus tachycardia (7/17; 41.1%), followed by monomorphic premature ventricular beats (6/17; 35.3%), less common were first-degree atrioventricular block (2/17; 11.7%) and sinus bradycardia 1/17; 5.8%). Notably, in G1 dogs, only sinus tachycardia and premature ventricular beats were observed. G2 dogs presented a number of total and banded leukocytes significantly higher than those of G1 (p = 0.002 and 0.049), in the same manner, the clinical score suggestive of SIRS (3 vs. 2.1) was significantly higher in G2 than in G1 dogs (p = 0.01). Moreover, a significantly higher value of cTnI was observed in the G2 group compared to the G1 group (p = 0.006). Data presented here suggested a cardiac involvement in dogs with SIRS, analogously to humans, that may significantly influence the patient’s prognosis.
Clinical case of peri-implantitis after orthodontic treatment
Authors:   FSBEI HE Stavropol State Medical University, Stavropol, Kobylkina T. L. , Perikova M. G. ,   FSBEI HE Stavropol State Medical University, Stavropol, Enikeev A. M. ,   FSBEI HE Stavropol State Medical University, Stavropol, Gatilo I. A. ,   FSBEI HE Stavropol State Medical University, Stavropol
Published: November 2022

The materials of the article contain a description of the clinical and radiological picture of peri-implantitis. The operation of dental implantation was performed at the beginning of the retention period in orthodontic treatment. Plastic crowns on temporary abutments were made a few days after the surgical stage. As a result of immediate occlusal load and installation of dental implants in the early stages of the retention period of orthodontic treatment, their disintegration occurred.
Breastfeeding: historical and medical aspects
Authors:   Orenburg State Medical University, Kaspruk L. I.
Published: November 2022

In August 2022, World Breastfeeding Week was held. Breastfeeding is a type of nutrition that has developed within the biological evolution of all mankind and refers to the appropriate nutrition of a newborn infant. Natural feeding creates directly protective and stimulating body options. A complex chemical and biological composition of breast milk renders a huge range of functions of protection and regulation of the development and differentiation of the child's body. In this context, nutrition is the basis of child health programming. Historically, each ethnic group has developed its own practice in baby feeding for centuries, which was determined by climatic and geographical features. Due to various national traditions of feeding, a modern type of feeding has developed, which does not lose its relevance in modern times.
Relación entre el fármaco semaglutida y la reducción de peso en pacientes con obesidad: una revisión sistemática
Authors: Alejandro Montalván Daniel Efraín , Prieto Fuenmayor Carem Francelys , Ortiz Benavides Rina Elizabeth
Published: November 2022

El tratamiento farmacológico para la obesidad es muy limitado, entre los existentes en el mercado, destaca la Semaglutida, ampolla subcutánea que se aplica semanalmente y se usa en pacientes con diabetes y obesidad. Objetivo. Establecer la relación de Semaglutida como un potencial fármaco para el tratamiento de obesidad. Método. Estudio de tipo descriptivo, principalmente enfocado en la revisión y análisis de investigaciones publicadas en bases de datos científicas de alta relevancia, restringiéndose únicamente a publicaciones del 2015 en adelante (2022) que engloben como tópico principal el uso de Semaglutida. Resultado. Se identificaron 802 registros en las bases de datos, aplicando los criterios de selección se identificaron 45 artículos como potenciales fuentes de información, finalmente se seleccionaron 15 artículos con datos altamente relevantes para esta revisión, donde se consideró la dosis del fármaco para la reducción de peso se observa que a mayor cantidad de Semaglutida se obtiene una reducción significativa de peso, llegando a una media de 11.82 kg. Conclusión. El tratamiento semanal con Semaglutida administrada a nivel subcutánea con cambios en el estilo de alimentación y actividad física, dan como resultados pérdida de peso sostenida en el tiempo clínicamente relevante, pudiendo llegar a la aplicabilidad en pacientes cuyo tratamiento por otros métodos más convencionales no es eficiente.
Rehabilitación Propioceptiva del Síndrome de Hombro Doloroso
Authors: Guaman Capito Cecilia , Pilco Toscano Cynthia , Villota Rodríguez Patricia
Published: November 2022

El hombro es una de las regiones anatómicas de mayor movilidad en la vida cotidiana, siendo una de las causas de consulta más frecuentes en el área de fisioterapia para su rehabilitación, pues la primera línea de acción es el tratamiento conservador del hombro; por ello, es de suma importancia conocer y evaluar el complejo articular del hombro, así como también de la región cervicotorácica, con los resultados de la valoración establecer una estrategia de tratamiento que pueden ir desde la terapia manual, el masaje terapéutico, cambios de temperatura hasta el empleo de otros agentes físicos. Paciente femenino de 42 años, con ocupación de asistente odontológica; no reporta discapacidad previa. Como antecedente médico se presenta accidente de tránsito en motocicleta sin producir fractura de hueso ni luxación, ocurrido ocho años antes de la consulta en fisiatría, la paciente tiene afectado el desarrollo de las actividades de la vida cotidiana. Recibió serie de tratamientos durante 10 sesiones, en las cuales se aplican agentes físicos, dado que anteriormente recibió tratamiento farmacológico sin resultados favorables. Se aplica protocolo de rehabilitación fundamentado en las técnicas de propiocepción y al finalizar la terapia la paciente reporta dolor leve, y mejora en la realización de actividades de la vida diaria.
Robustez em redes mutualísticas entre aves frugívoras e plantas: efeitos ecológicos, morfológicos e taxonômicos
Authors:   , Lima Wesley Oliveira de
Published: November 2022

A frugivoria e a dispersão de sementes por aves são processos ecológicos fundamentais na manutenção e conservação das florestas tropicais e para a resiliência dos ecossistemas. A partir de dados de literatura e amostras fecais coletadas no campo, investigamos fatores que podem atuar sobre a relação entre aves frugívoras e o consumo de frutos, como a massa corporal, as relações de nicho e grupos taxonômicos das espécies e como eles podem afetar a robustez de redes de interações mutualísticas ave x planta. Utilizando sobreposição de nicho de HornMorisita, coeficiente de variação da massa corporal e o índice de variação da distinção taxonômica como variáveis explanatórias, aplicamos uma regressão linear múltipla para testar as hipóteses de que o aumento da robustez em redes de frugivoria ave x planta ocorre onde as aves têm maiores sobreposições de nicho trófico e menores variações de massa corporal, e diminuição da robustez onde sejam mais taxonomicamente diversas, como resposta à menor redundância funcional. A massa corporal de aves e sobreposição de nicho não explicaram a variação da robustez em redes de dispersão de sementes. Por outro lado, os resultados demonstraram efeito para a variação da distinção taxonômica, sugerindo que, quanto a maior a distinção taxonômica das aves em uma assembleia de frugívoros, maior a robustez das redes. Algumas hipóteses são sugeridas para explicar esse efeito. Sejam quais forem os fatores que levam a varDT a favorecer a robustez das redes mutualísticas ave-planta, os resultados demonstram que conservar a diversidade acima do nível de espécies, e não apenas espécies limitadas a poucos grupos taxonômicos, pode ser uma importante estratégia para a manutenção dos ecossistemas ao longo do tempo.
Modelos hidrológicos híbridos para a bacia do rio Paraíba do Sul: acoplando redes neurais artificiais com transformada wavelet para previsão de vazão em curto prazo com ênfase na previsão de vazões extremas
Authors:   , Gorodetskaya Yulia
Published: November 2022

O rio Paraíba do Sul flui através da mais importante região industrial do Brasil, entre as cidades do Rio de Janeiro e de São Paulo. De acordo com a Agência Nacional de Águas, a bacia do rio Paraíba do Sul é caracterizada por conflitos de usos múltiplos de recursos hídricos (abastecimento urbano, diluição de esgotos, irrigação e geração de energia hidrelétrica). Em função de sua importância, o desenvolvimento de modelos precisos de previsão de vazão pode assumir valor estratégico para a gestão da quantidade e da qualidade de água nesta bacia. Estes modelos podem apoiar a tomada de decisão de gestores públicos sobre alertas para condições extremas de inundação ou seca e pode se tornar um elemento-chave para proteger a sociedade e favorecer uma reação oportuna, reduzindo efetivamente danos socioeconômicos. Os modelos baseados na inteligência artificial têm sido aplicados com sucesso para resolver problemas não-lineares em hidrologia. Nas últimas duas décadas, a transformada wavelet, uma técnica de pré-processamento de dados, tem sido estudada para uso em análise de séries temporais e tem se mostrado muito eficaz em dados não estacionários. A transformada wavelet divide as séries temporais originais em subcomponentes que servem como entradas para modelos de inteligência artificial. Assim, fornecem uma representação de tempo-frequência de um sinal em diferentes períodos no domínio do tempo, além de informações sobre a estrutura física de dados. Esta pesquisa visa contribuir com o fornecimento de uma metodologia de desenvolvimento de dois tipos de modelos híbridos chamados WANNone e WANNmulti acoplando redes neurais artificiais com uma técnica de pré-processamento de dados baseada em transformada wavelet À T rous. Os modelos desenvolvidos são aplicados para previsão de vazão natural média diária de 1, 3, 5 e 7 dias à frente em 8 estações fluviométricas localizadas na bacia do rio Paraíba do Sul. O desempenho dos modelos baseados em wavelets e redes neurais artificiais é comparado com o dos modelos convencionais de redes neurais artificiais (ANN). Os resultados revelam que o desempenho dos modelos WANNone e WANNmulti são significativamente superiores aos modelos ANN em termos de medidas de eficiência da previsão MAPE, RMSE e R2 em todos os horizontes de previsão testados para todas as estações modeladas. Em termos de aplicabilidade a determinados cenários, o modelo WANNmulti consegue representar melhor os ciclos de vazões baixas, em cenários de seca, ao passo em que WANNone consegue acompanhar melhor a magnitude das vazões extremas altas, em situações de risco de inundação.
Écrire et éditer une histoire philosophique et politique : l’Histoire des deux Indes de l’abbé Raynal (1770-1780)
Authors: Brot Muriel
Published: November 2022

Dealing with the making and success of Histoire des deux Indes, its scope and ideological goals, this paper combines the historical approach with textual analysis so as to highlight the richness, complexity and import of a pioneering text in the fields of colonial administration and political economics, among other interests. Assessing the studies devoted to this work over the last few decades, the article specifically examines Raynal’s actual contribution to this Histoire des deux Indes which was published under his name but written by more than one hand, a contribution which has been philosophically and politically questioned.
Le tableau d’Anne-Louis Girodet : Guillaume Thomas Raynal et Jean-Baptiste Belley. La réhabilitation du philosophe ?
Authors: Dorigny Marcel
Published: November 2022

Ce tableau de Girodet, daté de 1797, s’inscrit dans un triple contexte historique reliant la Révolution française, la Révolution des esclaves de Saint-Domingue et l’évocation des débats des Lumières autour de l’esclavage, de la traite négrière et de la légitimité des colonies à travers la présence marquée du buste de Raynal. Le personnage central, Jean-Baptiste Belley, fut le premier député noir siégeant dans une assemblée nationale française. Le buste du fameux Guillaume-Thomas Raynal est ici représenté aux côtés du député noir. Raynal était mort le 4 avril 1796. Grand pourfendeur de l’esclavage et de la traite dès les années 1770, Raynal avait incarné la lutte radicale contre le système colonial de son siècle. Mais, et c’est essentiel pour interpréter la portée du tableau, Raynal au moment de sa mort était en grande partie déconsidéré aux yeux du public patriote. La rupture entre le philosophe, réputé prophète de la Révolution, et les révolutionnaires est intervenue brutalement, par la lecture devant l’Assemblée constituante de sa fameuse Lettre à l’Assemblée nationale du 31 mai

1791 par laquelle il dénonçait l’oeuvre révolutionnaire, reniant en grande partie les engagements qui avaient fait sa gloire. Ainsi, sa présence au centre du tableau valait rédemption : celui qui avait annoncé la venue imminente d’un « nouveau Spartacus » , s’il n’avait pas su prendre la mesure de la Révolution en cours à Saint-Domingue, en avait tout de même été l’annonciateur. Girodet associait ainsi le philosophe Raynal à Belley, « Spartacus nouveau » , incarnation du Noir libéré et libérateur au sein même de la capitale de la Révolution.
Observations on the Role of the Chambre de Consultation in the Administration of Justice in Pondicherry (1778-1827)
Authors: Parasher Gauri
Published: November 2022

En 1778, l’administration française en Inde a créé la Chambre de Consultation, composée de huit notables indiens, pour aider les juges français à administrer la justice auprès de la population indienne de Pondichéry. Analysant des sources judiciaires de la fin du XVIIIe et du début du XIXe siècle, cet article examine la création, le fonctionnement et la disparition de cette institution peu connue. Au cours de cet examen, je montre que cette chambre, bien que sa dénomination officielle évoque un corps consultatif, avait des fonctions juridictionnelles. Outre le conseil qu’elle dispensait aux juges Français sur les lois et coutumes indiennes, ses membres, appelés «arbitres » , avaient aussi la responsabilité de régler des litiges entre Indiens. En fait, en établissant la Chambre, le gouvernement Français a intégré les acteurs autochtones dans le système judiciaire du XVIIIe siècle et leur a conféré une autorité juridictionnelle. Finalement, l’accroissement de l’autorité de la Chambre au cours de son fonctionnement a joué un rôle décisif dans sa suspension par l’administration française du XIXe siècle. Néanmoins, l’histoire de cette institution nous révèle un aspect important du régime juridique français en Inde à cette époque.
Révolution(s) en Inde : dimensions coloniales, diplomatiques et culturelles, 1789-1799
Authors: Smith Blake
Published: November 2022

À la fin du XVIIIe siècle, l’image de l’Inde en France est celle d’une région sans histoire et incapable de progrès. Pour les philosophes, et notamment Montesquieu, ses moeurs millénaires et son système politique sont immuables : aucune révolution ne pourrait venir les bouleverser. Pourtant, pendant la décennie révolutionnaire, plusieurs facteurs compliquent la représentation de l’immobilisme indien : certains membres de la population indienne s’organisent politiquement à Pondichéry ; la diplomatie française en Inde cherche à déclencher une « révolution » antibritannique ; enfin, des textes littéraires produits en métropole imaginent le transfert de la Révolution française sur le terrain indien. Cet article analyse les représentations contradictoires de l’Inde. Il montre que c’est précisément lorsque l’activité politique des Indiens se révèle « révolutionnaire » , et échappe au contrôle des autorités françaises, que celles-ci font appel à la notion d’immobilisme indien.
La question des dépôts pétroliers au Cameroun : enjeux économiques et impérialistes (1947-1952)
Authors: Pokam Kamdem Moïse Williams
Published: November 2022

Durant la Seconde Guerre mondiale, les compagnies pétrolières anglosaxonnes (Socony Vacuum, Texas, Atlantic et Shell) avaient réussi à augmenter de façon substantielle leurs parts de marché dans les territoires français d’Afrique. La Compagnie Française de Pétroles (CFP) réagit à cette percée à partir de 1947. Une bataille commerciale et diplomatique pour la construction et le contrôle des dépôts pétroliers dans cette région s’engage alors. Douala, principal port du Cameroun, constitue l’un des enjeux majeurs de cette confrontation. L’objectif de cet article est de retracer l’émergence des activités d’entreposage de produits pétroliers au Cameroun, en replaçant toutefois cette question dans le contexte global de l’empire français d’Afrique après la guerre de 1939-1945. Il s’appuie sur des sources d’archives camerounaises et françaises.
Liderazgo cambiante y género social en procesos de cambio lingüístico
Authors: Gutiérrez Manuel
Published: November 2022

La investigación sociolingüística ha dado cuenta de la existencia de diferencias según el sexo de los hablantes y los usos lingüísticos en comunidades monolingües y bilingües. Sin embargo, no se ha ofrecido suficiente evidencia de lo que pasa con esas diferencias cuando grupos emigrantes dejan su territorio, en donde su lengua es dominante, y llegan a sociedades en que su lengua es minoritaria. La incorporación a la nueva sociedad desencadena cambios a nivel lingüístico, los cuales se acentúan a lo largo de las generaciones, como se ha demostrado en la situación de contacto que ocurre en los Estados Unidos entre el español y el inglés. Este artículo presenta resultados de datos del español de Houston, Texas, y los compara con muestras de habla del español de México. Se examinan tres aspectos gramaticales: el leísmo, los demostrativos y los diminutivos. Se sigue un enfoque variacionista para comparar los usos de acuerdo con el género de los hablantes. Los resultados indican que los hombres favorecen las variantes innovadoras en el ambiente monolingüe; sin embargo, el liderazgo cambia en el medio bilingüe, ya que las mujeres lideran los cambios favoreciendo las variantes innovadoras. El análisis también muestra que, en el caso de los diminutivos, forma considerada más femenina, el patrón se presenta de manera diferente.
Experimental characterization of the mobile underwater acoustic communication channel in Shallow Water
Authors: Matos Leni Joaquim de , Dias Mateus Sousa
Published: November 2022

This paper presents the results for the experimental characterization of the mobile underwater acoustic communication channel in shallow water through the statistics of the fading and the time and frequency dispersion parameters. Starting from measurements performed in Forno Bay, Arraial do Cabo, Rio de Janeiro, Brazil, using three hydrophones in the reception side, two CW signals (3 and 6 kHz) and three sequences of LFM chirps in different bands: 2 to 4 kHz, 5 to 7 kHz and 1 to 8 kHz, the mobile sounding was performed in that channel in order to characterize it as in narrowband as in wideband.
O anacronismo da aplicação do crime de deserção aos integrantes das Polícias Militares e dos Corpos de Bombeiros Militares em tempo de paz
Authors: Selmer Wellenton Joserli
Published: November 2022

O presente artigo discute a aplicação do crime de deserção em tempo de paz, previsto no art. 187 do Código Penal Militar, aos integrantes das polícias militares e dos corpos de bombeiros militares, considerados forças auxiliares e reserva do Exército. Além disso, investiga as repercussões cíveis, penais e processuais e o anacronismo diante do ordenamento jurídico vigente, ao estabelecer um paralelo entre legislação castrense, regimes jurídicos de servidores públicos, além do tratamento conferido ao trabalhador comum, submetido à Consolidação das Leis do Trabalho no caso de abandono do cargo ou emprego. Nesse contexto, serão observados a tutela penal da hierarquia e da disciplina nos crimes militares – em tempos de paz e de guerra –, cujo fundamento de validade parte da ordem constitucional vigente, até a legislação especial que rege as organizações militares. A pesquisa ganha relevância científica vez que aborda a área do direito penal militar numa perspectiva pouco explorada, ao estabelecer um paralelo entre o crime de deserção, seus impactos e a ordem normativa vigente. Por fim, apresenta anteprojeto de lei tendente a descriminalizar a deserção para os militares dos Estados, tornando a conduta infração administrativa de natureza grave, passível de exclusão das fileiras da corporação a que pertencer. A proposta busca conferir celeridade processual e efetividade da tutela jurisdicional, ao garantir um processo mais simples de desligamento da corporação militar do indivíduo cuja conduta não demonstra interesse em permanecer em suas fileiras.
O desenvolvimento de incubadoras através da Lei Nº 8.387/1991: uma análise no Polo Industrial de Manaus
Authors: Montenegro Júnior Leopoldo Augusto Melo , De Oliveira Marcelo Albuquerque , Pereira Marcelo Silva , Gomes Fabiana David de Oliveira , Nogueira Ricardo Jorge da Cunha Costa
Published: November 2022

Com um dos polos mais importantes e expressivos da América Latina, a Zona Franca de Manaus insere-se no contexto do desenvolvimento de incubadoras, através da Lei nº 8.387, de 30 de dezembro de 1991, que disciplina a aplicação de recursos em pesquisa, desenvolvimento e inovação (PD&I), tendo como área de abrangência a Amazônia Ocidental e o Amapá. Os chamados de convênios pela referida lei eram o principal mecanismo de financiamento de projetos para as incubadoras e empresas incubadas, tendo essa possibilidade expressa, a partir do Decreto nº 6.008, de 29 de dezembro de 2006, e não mais abrangida com a promulgação do Decreto nº 10.521, de 15 de outubro de 2020. Torna-se imprescindível, então, investigar como objetivo central deste trabalho como estão as iniciativas de criação e desenvolvimento de incubadoras, constatando se há incubadoras suficientes, na região, que contribuam para o nascimento e fortalecimento de novas startups e se a lei em questão tem contribuído para o surgimento dessas novas iniciativas. O quanto de investimento em PD&I as incubadoras receberam ao longo dos anos e se a alteração trazida pela Lei nº 13.674/2018 e Decreto nº 10.521/2020 são benéficas para a sociedade e tem o condão de trazer desenvolvimento regional para a Amazônia Ocidental e Amapá. Para se chegar ao objetivo geral, foram coletadas informações junto à Suframa responsável pelas análises dos projetos executados pelas incubadas na Lei de Informática da Amazônia Ocidental e Amapá, além de incubadoras ainda atuantes da região, demonstrando as tendências e reflexões sobre esse processo.
Classification of information about internet users from the standpoint of information security and the fight against illegal activities
Authors:   Equitas Center for the Study of Problems of Russian Law, Golubev A.Y. , Zhelnov I.I.
Published: November 2022

The classification of information about Internet users from the standpoint of information security is considered. The characteristic of each type of such information is given. The material is presented from the standpoint of the fight against illegal activities in the network space.
Sport et cardiopathies congénitales
Authors: Albinski Maciej , Mivelaz Yvan , Christmann Martin
Published: November 2022

La pratique du sport était traditionnellement considérée comme risquée, voire contre-indiquée chez les patients atteints d’une cardiopathie congénitale (CC). Dans cette revue narrative, nous détaillons les bénéfices de l’activité physique pour la santé cardiaque et générale des patients avec CC. Nous abordons l’intérêt des camps sportifs sous surveillance d’un spécialiste en cardiologie pédiatrique et nous présentons un algorithme établi dans la littérature professionnelle pour l’évaluation individuelle du risque de l’exercice physique chez les patients avec CC. Finalement, nous discutons de la participation au sport de compétition et de haut niveau pour les athlètes atteints de CC.
Cardiologie pédiatrique simple – le b.a.ba pratique
Authors: Soyka Rahel , Güss Isabelle
Published: November 2022

Une des décisions difficiles qu’un.e pédiatre doit prendre, est de savoir si des investigations plus approfondies sont nécessaires. Quand et comment faire part aux parents de ses réflexions de diagnostic différentiel demande beaucoup de doigté. Cela vaut tout particulièrement lorsqu’il s’agit du cœur. Comme presqu’aucun autre organe, chez tous les peuples le cœur est porteur d’émotions. Les symptômes cardiaques déclenchent donc chez les parents et les enfants (plus âgés) une vive inquiétude et des peurs – qu’elles soient justifiées ou non du point de vue médical. Nous souhaitons transmettre ici des indications pour le triage et la prise en charge des enfants avec des symptômes cardiaques, et quelques tuyaux et réflexions pouvant être utiles dans la pratique quotidienne.
PENGARUH EFEKTIVITAS KEPEMIMPINAN KEPALA SEKOLAH DAN MOTIVASI KERJA TERHADAP KINERJA GURU
Authors: Setiana Adi Robith
Published: November 2022

The purpose of this study were to describe the influence the Leadership Effectiveness and Motivation on teacher Performance in MTs Serba Bakti Suryalaya Boarding School District of Tasikmalaya. The research method uses a quantitative approach. The population is all teachers in MTs Serba Bakti Suryalaya boarding school district of Tasikmalaya as many as 30 teachers. The sampling technique is saturated sample. Data were analyzed using regression analysis. The results of this study finding that there are significant effect partially and simultaneously of Leadership Effectiveness and Motivation on teacher Performance at MTs Serba Bakti Pondok Pesantren Suryalaya Tasikmalaya Thus, the higher the effectiveness of leadership, the better the performance and the higher the work motivation, the better the performance.

Keywords: Leadership Effectiveness, Motivation, Teacher Performance
KUALITAS PRODUK DALAM MENINGKATKAN MINAT BELI KONSUMEN PADA UMKM DI JAKARTA
Authors: Caniago Aspizain , Rustanto Agung Edi
Published: November 2022

This study aims to determine the effect of Product Quality on Consumer Buying Interest. This research used a quantitative approach, with data collection techniques using a questionnaire. In this study, the research tests of validity, reliability, correlation analysis, descriptive analysis, simple linear regression, t-test and coefficient of determination were applied. The results showed that the proposed hypothesis was accepted because it showed positive and significant hypothesis test results. The results of this study indicate that the Product Quality has a significant effect on Buying Interest. The contribution of the independent variable (Product Quality) to the dependent variable (Buying Interest) is 72.6%.

Keywords: Product Quality, Consumer Buying Interest, Tokopedia
Pengaruh Akuntansi Forensik dan Kemampuan Auditor Investigatif dalam Pengungkapan Kecurangan
Authors: Mulyandini Vita Citra , Simatupang Frido Saritua
Published: November 2022

The competence and ability of the auditor, especially if he is an investigator, is needed in detecting cases in Indonesia. Competence is education, knowledge, experience, and/or expertise, both on examination and on certain matters or fields. The abilities that must be possessed by an investigative auditor are basic knowledge of accounting, auditing, internal control, investigations and so on. Then the auditor must also have technical abilities such as understanding the law and legislation, be able to make hypotheses and collect evidence and investigative auditors have a mental attitude such as being independent and complying with standards. This research was conducted in all state-owned banks in Indonesia. Quantitative method in this study to examine the sample and analysis the established hypotheses. Descriptive quantitative was type of this research, which is researcher distributing questionnaires to all respondents then given a score. The data in this study is primary data directly obtained from the research location with the technique of distributing questionnaires. The population in this study were all BUMN Bank Auditors who conducted investigative audits. Sampling used in this research is purposive sampling.
Unfair commercial practices and vulnerability of consumers in the digital marketplace
Authors: Pusztahelyi Réka
Published: November 2022

Digital innovations are transforming markets by changing the way how goods and services are being produced and sold as well as the content itself generated by consumers. In the digital market, algorithms provide personalised services, and, in this context, comfort functions tailored to consumer needs. In addition, data-driven technologies enable businesses to micro-target consumers with advertising and personalised offers, monitor competitors’ prices more easily, and provide personalised services based on positive product reviews reflecting previous shopping experiences, however, the additional (consumer protection) risks of these practices need to be addressed through state intervention. From this collection of complex problems, this paper focuses on unacceptable online commercial practices in business-to-consumer relations in light of the Booking.com case.
Gas explosion venting of 20-litre vessel with and without various length of vent ducts
Authors: Mikáczó Viktória
Published: November 2022

When gas explosion occurs in closed vessel, venting devices can reduce the pressure inside the protected equipment, and vent ducts can be used to direct burnt and unburnt mixtures. In this paper, some ductless and duct vented explosion measurements were performed in a standard 20-liter explosion chamber with 2.8 to 6.3 vol.% propane-air mixture at atmospheric pressure (1 barg) and ambient temperature (298 K). Experimental investigations were performed with different lengths of vent duct (0 meter, 0.15 meter, 1 meter). During the measurements, effects of vent ducts to the venting process had been studied. Aluminium foils were used as rupture disks with 30 mm diameter circular venting area. During each measurement, static activation overpressure of aluminium foil, maximum explosion overpressure of propane-air mixture, the gas deflagration index in case of the vented vessel, and the pressure drop along the 1 meter length duct were determined.
The relationship between seo and artificial intelligence
Authors: Somosi Zoltán
Published: November 2022

As digital marketing becomes increasingly important in both communications and sales, the right strategy can make companies more efficient. One possible method is to use Artificial Intelligence to develop a company's website in line with the requirements of Marketing 5.0. This paper examines the relationship between Artificial Intelligence and Search Engine Optimization. The question is whether the website can rank better, communicate in better quality and generate higher purchase intent than a marketing expert, a sales expert or even a consumer, based on predefined parameters.
Interpretation and contractual intention : Some issues concerning the partial invalidity of the contract
Authors: Juhász Ágnes
Published: November 2022

The interpretation of both the judicial act and the contract is an essential and much-researched topic of contract law since interpretative questions relating to the contract are raised in almost all cases. The intention is a basic ‘building block’ of contractual agreements, therefore, in case of a legal dispute, revealing the parties’ real intention is indispensable. Nevertheless, there are also cases where the application of certain legal consequences raises the need for interpretation. For instance, when a ground for invalidity concerns only a certain part of the contract, the legislator provides partial invalidity or the invalidity of the contract in its entirety. Regardless of what type of invalidity is declared as a general rule, contractual parties, or in case of debate, the court shall decide about the legal status of the parties’ contract. In the lack of the parties’ expressed declaration, the decision shall be made on the real, interpreted, or ultimately, on the hypothetic contractual intention of the parties. In the study, both the issues of the interpretation of the contract and the problem of partial invalidity are examined comprehensively by the review and analysis of both the Hungarian and foreign literature. It is also reviewed, how the interpretation theories and methods can help the exploration of the contractual parties’ real intention, if parties did not provide the future legal status of their contract for the case of partial invalidity.
Factor analysis of the personality dimensions of sales associates in the finance and insurance sector
Authors: Juhász István
Published: November 2022

The aim of the present study is to ascertain the factors of a sample containing 1000 people from the finance and insurance sector via the shortened version of the California Psychological Inventory probing the respective personality dimensions. The additional objectives include the comparison of previously identified results and factors obtained on a standardised Hungarian sample. In light of the above, I forward the following hypothesis H1): The number and content of the factors explored by the S-CPI (principal component analysis) on the present sample significantly differs from that of the number and content of factors identified and arrived at during the 1985 standardisation process, mainly due to the impact of the following dimensions: Sociability, Social presence, Dominance, and Self-Control. The practical application of the respective research results indicates a difference between the personality of the average Hungarian citizen and that of the average sales associates in the given sectors.
Storage of hydrogen in hydrates
Authors: Vadászi Marianna , Bölkény Ildi
Published: November 2022

The primary cause of global warming is the burning of fossil fuels. Therefore, we are looking for alternative solutions for electricity generation, such as the increased use of renewable energies such as solar, wind and hydropower. The main drawback of these energy generation methods is the high degree of weather dependence, highly unbalanced, so the creation of a complex energy storage system is of paramount importance. This system would store the excess energy as a buffer, balancing the periodicity between demand and supply. Hydrogen storage (hydrogen is produced by the electrolysis of water using renewable energy) in the form of clathrate can be one of the possible forms of energy storage. To facilitate hydrogen supply in a future with zero carbon emissions, it is necessary to examine the technical aspects and feasibility of adsorption of hydrogen in high surface area materials. The capturing of molecular hydrogen in a crystalline guest molecule, i.e., water, as a storage method is a relatively new technology. Hydrogen hydrate is a promising medium for hydrogen storage, with advantages such as low production cost, safety, lack of negative environmental effects. The aim of this study is to present the latest developments in hydrogen storage in the form of hydrates and to present the challenges of this research area.
Hydraulic testing of specialised water production structures (horizontal collector well) in riverbank filtration systems
Authors: Nyiri Gábor , Szűcs Péter , Zákányi Balázs
Published: November 2022

One of Hungary's strategic water sectors is the supply of drinking water, which relies heavily on so-called riverbank filtration systems. About 35-40% of the national drinking water supply comes from riverbank filtered aquifers. Today in Hungary, 40% of the population; nearly four million people's daily water needs are met from riverbank filtered aquifers. In the future, 75% of our drinking water sources will be bank-filtered, which means that they will also be of great importance for future water resource management. The main water abstraction device in these aquifers is the well, or a special type of well, the horizontal collector well (HCW). In our work, we will focus on the hydraulic investigation of these types of wells. Using modern modeling software, the impact of the special design of HCWs on groundwater flow conditions can be well modeled. In our work, the yield distribution between the arms and the impact on the potential relationships are discussed in more detail and the results of this modeling are presented.
Hungarian regulation and practice of confined space works in the water utilities sector
Authors: Zákányiné Mészáros Renáta , Tóth Gyula , Zákányi Balázs
Published: November 2022

In Hungary, public water facilities - drinking water works and wastewater disposal and treatment plants - are operated by companies with a valid water utility licence. During operation, the operator must ensure an organised working schedule, on-call and stand-by service which, in addition to a continuous and reliable service, enables it to intervene immediately in the event of a fault in order to remedy or mitigate operational and environmental damage and to restore service as soon as possible. In many cases, these unplanned interventions can be classified as work with boarding, such as work in manholes or pipelines, repair operations on hydroglobuses (water towers), or even unplanned interventions in waterworks reservoirs. In the course of our work, we summarise the regulation of boarding work in Hungary. We describe the possibilities of employer measures that are part of the regulation. We also compile a list of the most common operations in the water utilities sector and the dangers of boarding, which can be of great help to both those who authorise boarding and those who carry it out.
Case studies to illustrate the risks and accidents associated with felling in urban areas
Authors: Zákányiné Mészáros Renáta , Bereczky Attila , Zákányi Balázs
Published: November 2022

About 4 decades ago, logging in populated areas was still an unknown concept, and tree care was a concept almost a decade old. It was simply felling or cutting back trees by competent or incompetent professionals, sometimes causing damage and accidents. The current legal regulations will be presented, followed by the commonly used and specific personal protective equipment. This will be followed by a series of case studies to illustrate the dangers of felling trees in populated areas. How these accidents could have been prevented and avoided will be described. The cases range from 1977 to the present day. The incidents that occurred were evaluated using statistical methods. This can be a great help for future proposals to amend the Forest Safety Regulations (Decree 15/1989 (8.X.)).
Investigating the reopening potential of medium enthalpy abandoned oil wells with Bayesian networks
Authors: Kárpi Marcell , Szilágyiné Sebők Szilvia , Zákányiné Mészáros Renáta
Published: November 2022

The study examines the suitability of a new analytical method that can provide reliable results to end users during geothermal investments. The use of individual risks, influencing factors, and evidence with appropriate complexity can support sound, considered decisions. In the research work, we investigated the reopening potential of three barren wells for heat recovery in a sample area in north-eastern Hungary using Bayesian probability-based nets. In our model, the replacement of current fossil energy use with geothermal energy was simulated, the effect of which was expressed in tonnes of CO2 emissions saved. Our studies confirmed the suitability of reopening and geothermal utilization of low-enthalpy infertile wells.
A human safety approach to safe maintenance
Authors: Zákányiné Mészáros Renáta , Kárpi Marcell , Norbert Tamás , Zákányi Balázs
Published: November 2022

The deterioration of the technical condition of plant equipment is a common phenomenon today. This is increasingly contributing to breakdowns and accidents, according to the experience of national and international authorities. Plants that are operating with an inadequate maintenance strategy are nowadays approaching the end of their design life and thus represent an increased risk of accidents. Ageing processes are often accelerated by operators' underestimation of the effects of stresses and strains on equipment and the extent of degradation mechanisms, and consequently by inadequate design and operation of condition monitoring and maintenance procedures. The aim of our work is to investigate domestic and foreign trends in the light of modern maintenance optimization methods and to make related recommendations for optimizing maintenance scheduling for domestic employers.
Pengaruh Penggunaan Media Sosial Pada Kehidupan Sehari-hari Terhadap Prestasi Belajar Matematika Peserta Didik
Authors: Farangky Taaraungan  , Jhon R. Wenas  , James U. L. Mangobi
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh media sosial dalam kehidupan sehari-hari terhadap prestasi belajar matematis siswa. Metode yang digunakan adalah metode survei bentuk korelasional. Sampel penelitian adalah kelas X yang dilaksanakan di SMK PP GMIM Tomohon yang terdiri dari 1 kelas. Instrumen penelitian penggunaan media sosial menggunakan angket dan hasil belajar siswa menggunakan nilai rapor semester genap. Data penelitian yang didapat melalui angket untuk 38 orang sebanyak 30 soal yang dinyatakan valid yaitu 25 soal angka reliabilitas yaitu 0,658 dan tidak valid yaitu 5 soal angka dan demikian ke 5 item tersebut dibuang. Terdapat hubungan antara penggunaan internet dalam kehidupan setiap hari terhadap prestasi belajar matematika peserta didik yaitu thitung=3,667>ttabel=2,028 dengan r=0,519. Hasil penelitian dari persamaan regresi: Ŷ=80,85+0,002X. Oleh karena itu hasil penelitian uji regresi menunjukkan terdapat pengaruh penggunaan media sosial dalam kehidupan sehari-hari terhadap prestasi belajar matematika siswa berpengaruh positif secara signifikan.