Abstract IA021: The All of Us Research Hub: A dataset for all of us
Authors: Watson Karriem S. 
Published: January 2023

The All of Us Research Program is building one of the nation’s largest most diverse research platforms that is transforming the future of health by providing researchers expansive, integrated, diverse health data including populations historically underrepresented in biomedical research (UBR). The All of Us dataset is available through the All of Us Research Hub, a centralized, secure, cloud-based platform examining biological, behavioral, and environmental factors that influence health and a broad range of diseases and conditions, including cancer. Participant data includes biological samples, health and social determinant surveys, electronic health records (EHR) and wearable data. Data is available through a private and secure tiered system, with anonymized aggregate data on an open-access public tier, and curated, individual-level, and genomic data on registered and controlled tiers. As of August 2022, the dataset includes over 518,000 participants, 80% UBR and 50% racial and ethnic minorities. Of the 227,000 participants who share EHR, over 42,000 indicate at least one form of cancer diagnosis and nearly 200 different cancer types. More than 2,800 researchers on the All of Us Researcher Workbench study this data, 21% of whom are underrepresented in the biomedical workforce (UBW) by race and ethnicity, from 393 institutions across 47 states. The diversity of research powered by All of Us data matches the diversity of its participants and researchers, as more than 150 projects have “cancer” in the project title and over 240 in the scientific question being studied. To date, there are five cancer-focused publications using the data—demonstrating the program’s early impact in cancer research. The program is intentional in ensuring data access to a diverse researcher community. These efforts include investing in the researcher pipeline and building capacity—from K-12 including educators, undergraduate and graduate students, post-docs and early stage investigators, seasoned researchers, and community and citizen scientists. At the collegiate level, one example is the Research Scholar Program (RSP), an annual offering of professional development workshops and curriculum, providing mentorship and training to support students in a research project utilizing All of Us data. RSP students present at the annual Minority Student Research Symposium, where in 2022, 27 UBW research scholars presented their findings to more than 300 attendees. For early-career investigators, the Baylor College of Medicine UBR Faculty Summit provides training on the Researcher Workbench and year-long support for attendees to continue research in teams utilizing All of Us data. Another capacity building effort is one with engagement partners RTI and the Community Campus Partnerships for Health to provide support for faculty, post-doctoral fellows, and students in six HBCUs to participate in an All of Us Researcher Academy that will provide training, technical assistance, and network-building for researchers and their mentors.

Citation Format: Karriem S. Watson. The All of Us Research Hub: A dataset for all of us [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA021.