bluuebunny/crossref_metadata_2025 huggingface dataset:
Medical mobility and intersectionality across the United States-Mexico border
Authors: Vega Rosalynn
Published: November 2018

The objective of this article is to analyze how intersectional processes shape differing degrees of medical mobility (defined as facility of movement across national borders for the purposes of obtaining health care services or pharmaceuticals) across the U.S.-Mexico border for Spanish-speaking Hispanics and English-speaking Whites. Furthermore, this document explores how intersectional factors such as race, language, socioeconomic status, and citizenship shape medical mobility patterns. The research used ethnographic methods (in-depth interviews and participant observation) over a period of sixteen months (from May 2017 until September 2018) in Hidalgo County in the Rio Grande Valley of Texas. The results of the research are an ethnographic understanding of the limits of citizenship for both documented and undocumented health care seekers in the border region, and the circumstances under which different border residents turn to bioconsumerism. The article’s conclusion makes a unique contribution to the literature by offering critical perspectives on relative privilege.
Advances in the Understanding of the Cannabinoid Receptor 1 – Focusing on the Inverse Agonists Interactions
Authors: Russo Silvana , De Azevedo Walter Filgueira
Published: November 2018

Background:

Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in
the central nervous system, whose crystallographic structure has recently been solved. Studies
will be needed to investigate CB1 complexes with its ligands and its role in the development
of new drugs.

Objective:

Our goal here is to review the studies on CB1, starting with general aspects and
focusing on the recent structural studies, with emphasis on the inverse agonists bound structures.

Methods:

We start with a literature review, and then we describe recent studies on CB 1 crystallographic
structure and docking simulations. We use this structural information to depict
protein-ligand interactions. We also describe the molecular docking method to obtain complex
structures of CB 1 with inverse agonists.

Results:

Analysis of the crystallographic structure and docking results revealed the residues
responsible for the specificity of the inverse agonists for CB 1. Most of the intermolecular interactions
involve hydrophobic residues, with the participation of the residues Phe 170 and
Leu 359 in all complex structures investigated in the present study. For the complexes with
otenabant and taranabant, we observed intermolecular hydrogen bonds involving residues His
178 (otenabant) and Thr 197 and Ser 383 (taranabant).

Conclusion:

Analysis of the structures involving inverse agonists and CB 1 revealed the pivotal
role played by residues Phe 170 and Leu 359 in their interactions and the strong intermolecular
hydrogen bonds highlighting the importance of the exploration of intermolecular interactions
in the development of novel inverse agonists.
Development of Pin1 Inhibitors and their Potential as Therapeutic Agents
Authors: Nakatsu Yusuke , Matsunaga Yasuka , Ueda Koji , Yamamotoya Takeshi , Inoue Yuki , Inoue Masa-ki , Mizuno Yu , Kushiyama Akifumi , Ono Hiraku , Fujishiro Midori , Ito Hisanaka , Okabe Takayoshi , Asano Tomoichiro
Published: November 2018

The prolyl isomerase Pin1 is a unique enzyme, which isomerizes the cis-trans conformation
between pSer/pThr and proline and thereby regulates the function, stability and/or
subcellular distribution of its target proteins. Such regulations by Pin1 are involved in numerous
physiological functions as well as the pathogenic mechanisms underlying various diseases.
Notably, Pin1 deficiency or inactivation is a potential cause of Alzheimer’s disease,
since Pin1 induces the degradation of Tau. In contrast, Pin1 overexpression is highly correlated
with the degree of malignancy of cancers, as Pin1 controls a number of oncogenes and
tumor suppressors. Accordingly, Pin1 inhibitors as anti-cancer drugs have been developed.
Interestingly, recent intensive studies have demonstrated Pin1 to be responsible for the onset
or development of nonalcoholic steatosis, obesity, atherosclerosis, lung fibrosis, heart failure
and so on, all of which have been experimentally induced in Pin1 deficient mice.

In this review, we discuss the possible applications of Pin1 inhibitors to a variety of diseases
including malignant tumors and also introduce the recent advances in Pin1 inhibitor research,
which have been reported.
Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection
Authors: Saikia Surovi , Bordoloi Manobjyoti , Sarmah Rajeev
Published: November 2018

The largest family of drug targets in clinical trials constitute of GPCRs (G-protein coupled receptors) which accounts for about 34% of FDA (Food and Drug Administration) approved drugs acting on 108 unique GPCRs. Factors such as readily identifiable conserved motif in structures, 127 orphan GPCRs despite various de-orphaning techniques, directed functional antibodies for validation as drug targets, etc. has widened their therapeutic windows. The availability of 44 crystal structures of unique receptors, unexplored non-olfactory GPCRs (encoded by 50% of the human genome) and 205 ligand receptor complexes now present a strong foundation for structure-based drug discovery and design. The growing impact of polypharmacology for complex diseases like schizophrenia, cancer etc. warrants the need for novel targets and considering the undiscriminating and selectivity of GPCRs, they can fulfill this purpose. Again, natural genetic variations within the human genome sometimes delude the therapeutic expectations of some drugs, resulting in medication response differences and ADRs (adverse drug reactions). Around ~30 billion US dollars are dumped annually for poor accounting of ADRs in the US alone. To curb such undesirable reactions, the knowledge of established and currently in clinical trials GPCRs families can offer huge understanding towards the drug designing prospects including “off-target” effects reducing economical resource and time. The druggability of GPCR protein families and critical roles played by them in complex diseases are explained. Class A, class B1, class C and class F are generally established family and GPCRs in phase I (19%), phase II(29%), phase III(52%) studies are also reviewed. From the phase I studies, frizzled receptors accounted for the highest in trial targets, neuropeptides in phase II and melanocortin in phase III studies. Also, the bioapplications for nanoparticles along with future prospects for both nanomedicine and GPCR drug industry are discussed. Further, the use of computational techniques and methods employed for different target validations are also reviewed along with their future potential for the GPCR based drug discovery.
Synthesis and Crystal Structure of Calix[4]arene Derivative Containing 1,3-Diketo Moieties
Authors: Xu Xuemei , Luo Zaigang , Ma Chao
Published: November 2018

The synthesis of the calix[4]arene derivative containing 1,3-diketo moieties via direct Claisen condensation without protection of the unsubstituted phenolic OH groups is reported. Single crystal X-ray diffraction analysis reveals that the calix unit to be in a cone conformation incorporating two 1,3-diketo subunits disposed in alternate position at the lower rim. And the crystal packing reveals that the overall packing of the complex is staggered anti-parallelly.
Design and Synthesis of Indole Pyrimidine Scaffolds as Potential KSP Inhibitors and Anticancer Agents
Authors: Chelamalla Radhika , Makula Ajitha
Published: November 2018

Background:

Several biological activities like anticancer, anti-inflammatory, analgesic,
antitubercular activities are reported for pyrimidine scaffolds. Extensive work on pyrimidine indole
scaffolds is required for antimitotic activity.

Objective:

To synthesize a novel Indole Pyrimidine scaffold via an efficient synthetic method and to
evaluate cytotoxic activity using various human cancer cell lines.

Methods:

4,4-(3-substituted phenyl)-6-methyl-N-[(Z)-(5-methyl-2-oxo-indolin-3-ylidene)amino]-2-
oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide derivatives were designed, synthesized and evaluated
for cytotoxic activity. The structures were confirmed by IR, 1H NMR, C13NMR and Mass spectroscopy.
The antiproliferative activities of the synthesized compounds were evaluated in vitro
against human cancer cell lines including HeLa and MCF-7.

Results:

The results revealed that most of the compounds possessed moderate to excellent potency.
Three among 10 molecules, showed more than 70% growth inhibition against all tested cancer cells.
The nature of the substituent group (R) on the indole ring affected significantly the anti-proliferative
activity of the molecules. The IC50 values of the most promising compound 4h are 76.4µM and
88.2µM against HeLa and MCF-7 respectively, which are closer to the standard compound doxorubicin.

Conclusion:

Molecular docking analysis demonstrated that 4b and 4d interact and bind efficiently
with KSP binding site. The preliminary results made us investigate for further development of potent
indole-pyrimidine scaffolds as cytotoxic agents
Simultaneous Determination of 17 Constituents of Chinese Wild Radix Salvia miltiorrhiza from Different Geographical Areas by Ultra-High Performance Liquid Chromatography Coupled to Triple Quadrupole Mass Spectrometry
Authors: Zhang Xiao-Dan , Cen Ye-Sheng , Yu Yan-Ge , Qi Zhe-Chen , Yang Dong-Feng , Wang Zi-Ying , Hou Zhuo-Ni , Liang Zong-Suo
Published: November 2018

Background and Objective:

Radix Salvia miltiorrhiza (RSM) has been used clinically for the
prevention and treatment of cardiovascular diseases; therefore, it is important to strengthen its quality
management. Considering multiple constituents when assessing RSM quality is essential. We established
a simple, rapid method to identify and quantify the major bioactive constituents in RSM using
ultra high performance liquid chromatography (UPLC) coupled to a triple quadruple mass spectrometry
(QqQ-MS).

Methods:

We analyzed 17 markers from 50 batches of wild S. miltiorrhiza samples that were collected
from different locations in China. The ultrasonic extracts of all samples were determined using the
UPLC-QqQ-MS method and were assessed by hierarchical cluster analysis (HCA).

Results:

We used this method to analyze 50 sample batches of the 17 compounds and obtained results
with excellent linearity (R2, 0.9915-0.9997), precision (relative standard deviation, RSD, 0.15-1.94%),
repeatability (RSD, 1.28-4.71%), stability (RSD, 0.97-5.60%) and recovery (RSD, 0.305-6.40%). The
hierarchical cluster analysis was used to classify the 50 samples based on the characteristics of the 17
compound markers.

Conclusion:

We demonstrated that the developed method was simple, reproducible and sensitive, and it
is capable of systematic and scientific evaluation for quality control of RSM. The HCA clearly demonstated
that the RSM samples from different locations were significantly different and the quality of wild
Radix S. miltiorrhiza could generally be judged according to its geographical origin.
Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets
Authors: Praveenkumar S. , Srigitha S. Nath , Dinesh Ram G. , Ramesh R.
Published: November 2018

Background:

In this paper, the design and computational modeling of microfluidic
channel capable of separating platelets and Red Blood Cell (RBC) from the other blood cells are
proposed.

Materials and Methods:

Separation based on their sizes is made possible by utilizing negative dielectrophoretic
(n-DEP) force in fusion with drag force. An array of 38º angled electrode separated
by 70 μm distance is designed within the microchannel and analyzed for non-uniform electric
field distribution.

Results and Conclusion:

The molecule movement within the microchannel under induced electric
field is simulated to demonstrate the separation using the particle trajectories module. A numerical
study is performed for the calculation of Clausius Mossotti (CM) factor, n-DEP force and drag
force.
Spontaneous Chest Abscess Caused by Salmonella Enterica subsp. Arizonae in the Desert Southwest; A Case Report and Review of the Current Literature
Authors: Antony Suresh , Cooper Leigh
Published: November 2018

:

Salmonella enterica subspecies arizonae is a rare pathogen but has been reported in the
literature in immunosuppressed and rarely immunocompetent patients. Most disease states have
been reported in animals and reptiles. Human exposure has resulted in a range of complications
from skin and soft tissue infections to bacteremia and periprosthetic joint infections. Predisposing
factors such as age, comorbidities, and use of Mexican folk healing practices increase the risk of
developing an infection. S. arizonae has been associated with gastrointestinal infections in several
parts of the country and on rare occasions have been isolated from skin and soft tissues, prosthetic
joints, and empyema.

Case:

This is a unique case of a large de novo chest abscess that developed in a 59-year-old diabetic
male from the Southwest region with cultures growing Salmonella enterica subspecies arizonae.
This patient presented without predisposing factors and did not appear to be ill at the time of admission.
He was treated successfully by aspirating the abscess along with a 2-week course of ceftriaxone
intravenously.
Study of the Effects of L-tryptophane Nanoparticles on Motor Behavior in Alzheimer's Experimental Models
Authors: Miri Andressa L. , Hosni Andressa P. , Gomes Jossinelma C. , Mainardes Rubiana M. , Khalil Najeh M. , del J.V. Marcano Rossana G. , da S. Pereira Mário C. , Kerppers Ivo I.
Published: November 2018

Background:

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the
progressive and incapacitating decay of cognitive, neuropsychiatric, and behavioral manifestations.
L-tryptophan is the precursor amino acid of serotonin, which is a neurotransmitter responsible for
mood balance and the sense of well-being and can be administered in the form of nanoparticles.

Objective:

This study analyzed the effectiveness of L-tryptophan nanoparticles and L-tryptophan on
behavioral physiological alterations resulting from AD in animal models.

Methods:

The sample consisted of 50 Rattus norvegicus rats, divided in 10 groups with 5 animals
each: one negative control (NC), three positive control groups (C3, C7, and C21), three groups treated
with L-tryptophan nanoparticles (T3N, T7N, and T21N) at the concentration of 1.5 mg, and three
groups treated with L-tryptophan (T3L, T7L, and T21L) at the concentration of 1.5 mg. The rats underwent
stereotactic surgery to induce AD through the injection of amyloid beta-amyloid peptide1-42 in
the intracerebroventricular region. All rats were submitted to pre- and post-surgery and post-treatment
motor behavior evaluation through the Later Water Maze (LWM) and elevated cross-labyrinth (ECL).
Histological analysis was performed to verify the presence of senile plaques, and the statistical analysis
used the unpaired T-test.

Results:

Significant intergroup differences were observed in some of the evaluated parameters between
treated and untreated groups.

Conclusion:

It was concluded that the treatment with L-tryptophan nanoparticles was beneficial to
improve behavioral reactions in the Alzheimer's model.
Smart Gn-Keto Nanohybrid Embedded Topical System for Effective Management of Dermatophytosis
Authors: Sharma Nisha , Misra Shashikiran
Published: November 2018

Background and Objectives: Dermatophytosis (topical fungal infection) is the 4th common
disease in the last decade, affecting 20-25% world’s population. Patients of AIDS, cancer, old age senescence,
diabetes, cystic fibrosis become more vulnerable to dermatophytosis. The conventional topical
dosage proves effective as prophylactic in preliminary stage. In the advanced stage, the therapeutics
interacts with healthy tissues before reaching the pathogen site, showing undesirable effects, thus resulting
in pitiable patient compliance. The youngest carbon nano-trope “Graphene” is recently used to manipulate
bioactive agents for therapeutic purposes. Here, we explore graphene via smart engineering by
virtue of high surface area and high payload for therapeutics and developed graphene–ketoconazole
nanohybrid (Gn-keto) for potent efficacy towards dermatophytes in a controlled manner.

Methods: Polymethacrylate derivative Eudragit (ERL100 and ERS 100) microspheres embedded with
keto and Gn-keto nanohybrid were formulated and characterized through FTIR, TGA, and SEM. In vitro
drug release and antifungal activity of formulated Gn-keto microspheres were assessed for controlled
release and better efficacy against selected dermatophytes.

Results: Presence of numerous pores within the surface of ERL100 microspheres advocated enhanced
solubility and diffusion at the site of action. Controlled diffusion across the dialysis membrane was observed
with ERS100 microspheres owing to the nonporous surface and poor permeability. Antifungal
activity against T. rubrum and M. canis using microdilution method focused on a preeminent activity
(99.785 % growth inhibition) of developed nanohybrid loaded microspheres as compared to 80.876% of
keto loaded microspheres for T. rubrum. The culture of M. canis was found to be less susceptible to
formulated microspheres.

Conclusion:

Synergistic antifungal activity was achieved by nanohybrid Gn-Keto loaded microspheres
against selected topical fungal infections suggesting a vital role of graphene towards fungi.
Comparative Cluster Based Mobile Routing Approach for Energy Efficiency in Optimization of Node location in WSNs
Authors: Sahani Sanjay Kumar , Yadav Raghav
Published: November 2018

Background & Objective:

The Energy efficiency in optimization of node sensor location
is considered as a design on Comparatively Cluster Based Mobile Routing Approach (CCBMRA)
likewise circle coverage and elliptical coverage. Location of boundary has deployment with CCBMRA
distribution of anchor node and un-anchor node or static sensor node.

Methods:

This proposed method has applied for distributed by anchor node positioned to measurements
of employing received signal strength. So it is important for intermediate processing phase to
achieved accurate positioning of SSN (Static Sensor Node). Moreover, ASN (Anchor Sensor Node)
transmitted signal accurate computational and energy efficiency in optimization through reduces the
number of cost factor, time and utilization of anchor node location. The research has established algorithm
and simulation experimental based mobile node localisation routing approached.

Result and Conclusion:

The experimental has achieved higher localisation precision in less nodes.
This paper suggests algorithm based on CCBMRA.
Improved Characteristics of Antipodal Vivaldi Antenna for UWBRADAR Applications
Authors: Kerarti Djalal Ziani , Marouf Fatima Zahra
Published: November 2018

Background & Objective:

In this paper, a simple design of antipodal Vivaldi antenna for
ultra-wideband Radar applications is presented.

Methods:

The antenna provided to operate across the entire UWB spectrum sins it covers a very
wide frequency band from 2.43 up to 13 GHz with better return loss characteristics. In addition, the
antenna offers high and flat gain in this band. The numerical designs of the antennas have been performed
by using the commercially available software CST MW, which it’s printed on Taconic substrate
with a dielectric constant of 4.5 and thickness 1.6 mm.

Results and Conclusion:

The antenna has a compact dimension of 40 × 50 mm2 achieve satisfactory
impedance matching and radiation efficiency.
Exploring microRNAs, Target mRNAs and their Functions in Leguminous PlantArachis hypogaea
Authors: Rajendiran Anjana , Vijayakumar Saravanan , Pan Archana
Published: November 2018

Background:

MicroRNAs (miRNAs) are a class of small non-coding, endogenous RNAs that regulate gene expression at post-transcriptional level. In plants, miRNAs are usually of 18-24 nucleotide in length and play humongous role by aiding in development, growth, defense, biotic and abiotic stress responses, etc.

Objective:

Arachis hypogaea is an economically important oil seed crop and human dietary source cultivated mostly in tropical and subtropical regions. In the present study, an initiative was taken to uncover miRNAs, their targets and functions in this important plant species.  Method: Comparative genomics strategy coupled with bioinformatics approaches was deployed for the identification of miRNAs, their corresponding targets and functions by exploiting biological databases and tools.

Results:

The study was able to identify 34 conserved miRNA candidates, belonging to 17 miRNA families, contributed by 23 and 3 precursor miRNAs from A. hypogaea Expressed Sequence Tags (EST) and Genome Survey Sequences (GSS), respectively. As well, 495 EST and 917 unigene sequences were predicted as targets for the identified miRNAs. Herein, psRNAtarget server and TargetFinder tool were used to predict unigene targets, whereas comparative genomics strategy was used for identifying EST targets. Functional annotation of the identified targets revealed that the identified miRNAs regulate mRNAs that participate in key biological and metabolic processes. Pathway enrichment analysis using KEGG database also revealed that they regulate important metabolic pathways including antibiotic biosynthesis, biosynthesis of unsaturated fatty acids, amino acids metabolism and flavonoid biosynthesis.

Conclusion:

The outcome of the study would aid experimental biologists to focus on these miRNAs to facilitate improved crop development and yield.
A Novel Pentagonal Shaped Planar Inverted-F Antenna for Defense Applications
Authors: Sharma Purnima , Kotecha Akshi , Choudhary Rama , Pratim Bhattacharya Partha
Published: November 2018

Background:

The Planar Inverted-F Antenna (PIFA) is most widely used for wireless communication applications due to its unique properties as low Specific Absorption Rate, low profile geometry and easy fabrication. In literature a number of multiband PIFA designs are available that support various wireless applications in mobile communication, satellite communication and radio frequency field.

Methods:

In this paper, a miniature sized planar inverted-F antenna has been proposed for dual-band operation. The antenna consists of an asymmetrical pentagonal shaped patch over an FR4 substrate. The overall antenna dimension is 10 × 10 × 3 mm3 and resonates at 5.7 GHz frequency. A modification is done in the patch structure by introducing an asymmetrical pentagon slot.

Results:

The proposed pentagonal antenna resonates at 5.7 GHz frequency. Further, modified antenna resonates at two bands. The lower band resonates at 5 GHz and having a bandwidth of 1.5 GHz. This band corresponds to C-band, which is suitable for satellite communication. The upper band is at 7.9 GHz with a bandwidth of 500 MHz. Performance parameters such as return loss, VSWR, input impedance and radiation pattern are obtained and analysed using ANSYS High- Frequency Structure Simulator. The radiation patterns obtained are directional, which are suitable for mobile communication.

Conclusion:

The antenna is compact in size and suitable for radar, satellite and vehicular communication.
New Approach to Modeling and Simulation of Chemical and Mass Transfer Processes in Column Apparatuses
Authors: Boyadjiev Christo , Boyadjiev Boyan
Published: November 2018

Objective:

The classical mass transfer theory is not applicable for modeling the mass transfer of chemical, absorption, adsorption and catalytic processes in column apparatuses, where the velocity distributions and interphase boundaries are unknown. The modeling of these processes is related with the creation of new type of convection-diffusion models (for qualitative analysis) and average-concentration models (for quantitative analysis), where the surface reactions are replaced by equivalent volume reaction, while the velocity and concentration distributions are replaced by average velocity and concentrations. The effect of the radial non-uniformity of the velocity in the average-concentration models is introduced by model parameters, which must be obtained experimentally.

Methods:

The new convection-diffusion and average-concentration models are obtained in the cases of different processes in column apparatuses: simple and complicated chemical reactions, physical and chemical absorption, physical and chemical adsorption, heterogeneous catalytic processes (physical and chemical adsorption mechanism). These models are presented in the monograph Chr. Boyadjiev, M. Doichinova, B. Boyadjiev, P. Popova-Krumova, “Modeling of Column Apparatus Processes” (Second edition), Springer- Verlag, Berlin Heidelberg, 2018.

Results:

Two hydrodynamic situations are considered, when the radial velocity component is equal to zero, in the cases of an axial modification of the radial non-uniformity of the axial velocity component and when the radial velocity component is not equal to zero.

Conclusion:

The use of experimental data, for the average concentrations at the column end, for a concrete process and column, permits to obtain the model parameters, related with the radial non-uniformity of the velocity. These parameter values permit to use the averageconcentration models for modeling of different processes.
Aspek Hukum Pelestarian Lahan Basah pada Situs Ramsar di Indonesia (Studi Terhadap Implementasi Konvensi Ramsar 1971 di Taman Nasional Tanjung Puting)
Authors: Anggara Alam Surya
Published: November 2018

AbstractThe Ramsar Convention have been transformed and implemented into Indonesian law. In practice, still found non-synchronized regulations that have not been able to implement the sustainable and wise use of wetlands. The prevention of peatland degradation must be holistic by involving the community and make intens socialization in order to create a sense of belonging and ownership. It is the purpose of this article to analyze the implementation of the Ramsar Convention 1971 on the peatland ecosystem protection and management at Tanjung Puting National Park, Central Kalimantan, and related to how Government efforts and policy to prevent the degradation of peatland since it was established as Ramsar Site in Indonesia.IntisariKetentuan-ketentuan dalam Konvensi Ramsar telah dilaksanakan dan ditransformasikan ke dalam peraturan perundang-undangan di Indonesia. Dalam praktiknya, masih ditemukan peraturan-peraturan yang tidak sinkron, sehingga belum dapat melaksanakan komitmen pemanfaatan lahan basah secara bijaksana dan berkelanjutan. Upaya pencegahan degradasi gambut harus dilaksanakan secara holistik dengan mengikutsertakan masyarakat dan mengintensifkan sosialisasi agar tercipta sense of belonging, dan ownership. Penelitian ini bertujuan untuk menganalisis implementasi Konvensi Ramsar 1971 terkait perlindungan dan pengelolaan ekosistem gambut di Taman Nasional Tanjung Puting, Kalimantan Tengah. Sekaligus untuk melihat sejauh mana upaya Pemerintah dalam mencegah degradasi ekosistem gambut, sejak Tanjung Puting ditetapkan sebagai Situs Ramsar di Indonesia.
Hybridity in Transitional Justice: Legacy of The “Khmer Rouge Tribunal”
Authors: Apro Danijel , Sudarmo Sudarmo
Published: November 2018

AbstractCountries throughout the world practice several forms of transitional justice, hoping to attain peace, democratic stability and reconciliation. They apply different mechanisms to achieve these goals. Thispaper offers a theoretical analysis of foundation, proceedings and legacy of the Extraordinary hambersin the Courts of Cambodia (ECCC). First, the Author examines the notion of the analysis of hybrid courts as a way of overcoming constraints that criminal justice mechanisms in post-conflict societies may face. Second, the Author explores the so-called “Khmer Rouge Tribunal”. Due to the significance and controversies that surround the ECCC, its work attracts great attention. Furthermore, political will is critical, so these hybrid judicial institutions should have more international support in terms of political means, funds, dissemination of results, and complementary mechanisms of transitional justice.IntisariNegara-negara di seluruh dunia mempraktikkan beragam bentuk keadilan transisional, dengan harapan untuk memelihara perdamaian, stabilitas demokrasi, dan rekonsiliasi. Mereka menerapkan mekanisme yang berbeda-beda untuk mencapai tujuan tersebut. Penelitian ini menyajikan analisis teori yang dilakukan terhadap landasan, proses, dan pengaruh Extraordinary Chambers in the Courts of Cambodia (ECCC). Pertama-tama, penelitian ini meninjau gagasan mengenai analisa terhadap pengadilan hibrida sebagai cara untuk mengatasi kendala yang dihadapi oleh mekanisme pengadilan pidana di masyarakat pascakonflik, dan kedua, mengeksplorasi apa yang disebut “Pengadilan Khmer Rouge”. Karena signifikansi dan kontroversi yang menyelubungi ECCC, karyanya menerima perhatian yang besar. Tekad secara politis sangat penting, sehingga pengadilan hibrida ini dapat memperoleh dukungan internasional lebih banyak dalam hal sarana politik, dana, penyebaran hasil, dan mekanisme untuk melengkapi keadilan transisional.
Diagnostics of the Life Deficiency of Life of the Population of Ukraine
Authors: Boichenko E. B. , Vasilchuk N. O.
Published: November 2018

The article is devoted to the determination of the lifespan deficiency of the population of Ukraine. The diagnostics is carried out on the basis of generalization of studies by domestic and foreign scientists in the context of lifespan. Calculations were made on the basis of official data of the State Statistics of Ukraine and the World Health Organization. In the article, by the lifespan deficiency of the population, it is suggested to mean actual shortage of a certain period of lifespan that has resulted from death coming from external and/or internal causes that prevent a person from living to the limits of his/her biological capabilities. The diagnostics is based on the methodology for constructing mortality tables of average expected lifespan for one year and five years old age groups. The results of the diagnostics made it possible to find that the real lifespan deficiency in Ukraine is 12.4 years. In addition, it was determined that the potential lifespan deficiency of the Ukrainians from so-called “diseases of behavior” is 2.47 years. It was substantiated that, in the context of overcoming mortality from such diseases as AIDS, active tuberculosis, alcoholism, and drug addiction by adjusting the behavior of the population in society, lifespan can increase by almost three years.
Any modification of the Born rule leads to a violation of the purification and local tomography principles
Authors: Galley Thomas D. , Masanes Lluis
Published: November 2018

Using the existing classification of all alternatives to the measurement postulates of quantum theory we study the properties of bi-partite systems in these alternative theories. We prove that in all these theories the purification principle is violated, meaning that some mixed states are not the reduction of a pure state in a larger system. This allows us to derive the measurement postulates of quantum theory from the structure of pure states and reversible dynamics, and the requirement that the purification principle holds. The violation of the purification principle implies that there is some irreducible classicality in these theories, which appears like an important clue for the problem of deriving the Born rule within the many-worlds interpretation. We also prove that in all such modifications the task of state tomography with local measurements is impossible, and present a simple toy theory displaying all these exotic non-quantum phenomena. This toy model shows that, contrarily to previous claims, it is possible to modify the Born rule without violating the no-signalling principle. Finally, we argue that the quantum measurement postulates are the most non-classical amongst all alternatives.
BOUT THE PROBLEM OF ANALYSIS RESISTANCE BEARING SYSTEMS IN FAILURE OF A STRUCTURAL ELEMENT
Authors: Perelmuter Anatoly V. , Kabantsev Oleg V.
Published: November 2018

This paper focuses on the methods of calculating load-bearing systems in the case of a failure of a structural element. This kind of failure makes it necessary to assess further behavior of the structure with a possibility of the progressive collapse development. The stress-strain state analysis of a load-bearing system in the case of a failure of a structure is carried out by two main methods – static and dynamic calculation. It is shown that the static calculation (quasi-static analysis using the dynamic amplification factor) is not a universal method. This paper justifies the application of the direct dynamic calculation in the mode of direct integration of motion for the design analysis of load-bearing systems with high rigidity stories (protection structures for a load-bearing system). It also gives recommendations for selecting parameters of the direct dynamic calculation in the case of a failure analysis of a bearing structure.
MOISTURE REGIME CALCULATION FOR SINGLE-LAYER ENCLOSING STRUCTURES USING DISCRETE-CONTINUAL MATHEMATICAL MODEL
Authors: Gagarin Vladimir G. , Zubarev Kirill P.
Published: November 2018

The paper describes moisture regime calculation for single-layer enclosing structures using discrete-continual method. A formula for calculation of moisture potential dependence on time in any enclosing structure section, at any time, under continuous control for temperature distribution, has been derived. Moisture regime calculation results under the proposed method have been compared to results obtained by well-known methods by V.G. Gagarin and V.V. Kozlov for aerated concrete single-layer enclosing structure. It has been found out that the proposed method gives quantitative and qualitative results similar to results obtained using Gagarin’s unsteady-state method.
ARCHITECTURAL MODELLING OF “SOUND” PERGOLA
Authors: Lesovik Valery S. , Pershina Irina L. , Popov Dmitry Yu. , Shevchenko Andrey V.
Published: November 2018

The article describes architectural solutions of pergolas adapted for the reproduction of synthesized acoustic space. The solution is represented by means of computer modelling and visualizes both processes and ob-jects on the example of construction and calculations. The project design of architectural models is an integral part in the practical reconstruction of the geospatial space studied by the architectural geography.
Efek Penggunaan Ekstrak Buah Nanas (Ananas comosus L. Merr) terhadap Kualitas Fisik Daging Kerbau
Authors: Jahidin Jaya Putra , Monica Metha
Published: November 2018

Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan ekstrak  buah nanas terhadap kualitas fisik daging kerbau.Daging kerbau selama ini cenderung dihindari digunakan karena mempunyai serat daging yang lebih kasar sehingga kurang begitu disukai serta mempunyai kualitas fisik yang rendah (alot) karena biasanya kerbau dipotong pada umur yang tua. Permasalahan ini diharapkan dapat diatasi dengan cara memanfaatkan buah nanas yang diproses menjadi ekstrak nanas sebagai bahan pengempuk daging kerbau. Penelitian ini dilaksanakan dengan menggunakan Rancangan Acak Lengkap dengan tiga perlakuan perendaman yang berbeda : P1 : (0 menit), P2 : (15 menit)P3 : (30 menit) dengan tiga ulangan. Peubah yang akan diamati meliputi nilai pH, daya mengikat air, susut masak dan keempukan. Penelitian ini dirancang dengan menggunakan desain rancangan acak lengkap (RAL) dengan 3 (tiga) ulangan. Hasil dari penelitian ini menunjukkan bahwa perendaman daging kerbaudalam ekstrak nanas dapat meningkatkan daya ikat air, keempukan, dan susut masak namun tidak mempengaruhi nilai pH daging sampai dengan lama perendaman 30 menit.
Mars 2018 – och sedan? Om successionsfrågan i Putins Ryssland
Authors: Petersson Bo
Published: November 2018

March 2018 – and then what? The issue of political succession in Putin’s Russia
As president of Russia and a prominent political leader, Vladimir Putin has consistently endeavoredto legitimize his rule by appealing to central political myths and taken-for-granted truths inRussian society. In rhetoric and official communication, he emerges as the guarantor of domesticorder and stability, the protector of traditional values, and a staunch advocate of Russia’sstatus and position as a great power in a world often depicted as hostile. What is being communicatedhere, and apparently finds resonance among broad segments of public opinion, is thaton all these parameters Putin is uniquely qualified to lead Russia. Four times in the course of18 years, Putin has been elected president in the first round of elections, and throughout thisperiod he has received high rankings in regular monthly opinion polls. However, his legitimationstrategies have been so firmly linked to the persona of Putin that we may speak of an emergingdilemma with his fourth presidency. Who could fill his shoes as his successor? The articleanalyzes this dilemma, taking its point of departure in Weber’s seminal theorizing on types oflegitimate authority and the routinization of charisma. It discusses the evident dearth of crediblesuccessor candidates, and concludes by discussing possible actions for dealing with or postponingthe issue of succession.
The Impact of Hajj on the Society of Bangladesh
Authors: Islam Md Thowhidul
Published: November 2018

Millions of Muslims from around the world including Bangladesh pour perform Hajj every year. Being the largest gathering of the Muslims, the Hajj has got immense socio-economic and cultural impacts on every Muslim society as well as Bangladesh. Hajj develops a unique symbol of unity, equality, universality, co-existence, brotherhood, indiscrimination, peace and tolerance, through performing common rituals, among the individuals, societies and nations belonging to different races, castes, ethnicities, colors, and languages, which create differences in everyday life of human beings. Bangladeshi Hajjisâ€™ views towards women are more positive as gender interaction is a natural part of Hajj, while it is uncommon in the country. The positive teachings of Hajj particularly of pure Aqidah, produced several revolutionary movements in Bengal such as the Faraidi movement of Hajji Shariatullah with the aim of purifying Muslim society from superstitious Aqidah and practices. Hajj works as a social platform of getting together for Bangladeshi people at Makkah and Madinah. Hajj has developed the private tour operating industries in Bangladesh to facilitate the Hajjis. Transaction of billions of dollars takes place commercially during Hajj, while many commodities are exchanged informally. The Hajjis enjoy a very special dignity and status in the society of Bangladesh. Hajj creates an inter-cultural amalgamation combining various elements of different cultures particularly of Arabian. Hajj increases knowledge of the Hajjis both experimental and theoretical through various means. Bangladeshi Hajjis consider Hajj as the preparation for death; and thus try to remain isolated from the worldly activities and observe the religious duties strictly. This transformative property enables the Hajjis to pursue a more purified life and they become a model of spirituality and religiosity. Hajj not only moulds the Hajjis into sincere and practicing Muslims, but also the society at large with their honesty and piety. Thus, Hajj brings immense impacts on the society, economy, education, religiosity and culture of Bangladesh. This chapter is aimed at analyzing the socio-economic and religio-cultural impacts of Hajj on the society of Bangladesh. It also included the perspectives of the society with a view to better understanding the influence of Hajj on the Hajjis, non-Hajjis and the society at large.
Outcomes of elective gonadectomy procedures performed on dogs and cats by veterinary students and shelter veterinarians in a shelter environment
Authors: Kreisler Rachael E. , Shaver Stephanie L. , Holmes John H.
Published: November 2018

OBJECTIVE To determine complication rates for elective gonadectomy procedures performed by veterinary students on dogs and cats in an animal shelter, characterize these complications, and compare rates with those for shelter-employed veterinarians (SEVs).

DESIGN Retrospective cohort study.

ANIMALS 10,073 dogs and cats for which gonadectomy was performed by a veterinary student (n = 3,048 surgeries) or SEV (7,025 surgeries) at an urban animal shelter over a 16-month period.

PROCEDURES Electronic medical records for included dogs and cats were reviewed and data collected regarding patient signalment, duration of gonadectomy, surgeon type (student or SEV), and types of surgical complications recorded (including death or euthanasia) during the period from anesthetic induction to 72 hours after surgery. Complication and mortality rates were compared between veterinary students and SEVs.

RESULTS No significant differences were identified between students and SEVs regarding rates of overall complications for both species, minor complications for both species, major complications for both species, and overall complications for dogs or cats specifically. The most common complications were self-limiting, with no long-term consequences, for both students and SEVs. Differences in mortality rates between students and SEVs could not be definitively determined owing to low numbers of nonsurviving patients.

CONCLUSIONS AND CLINICAL RELEVANCE With judicious case selection and as a part of a surgical training program, complication rates for veterinary student–performed gonadectomy procedures for dogs and cats were no different from those for SEV-performed gonadectomy procedures. We believe such information regarding patient outcomes will allow shelter staff to make informed decisions and help them in discussions with stakeholders who may have concerns about student participation.
Pengaruh Gaya Kepemimpinan Dan Motivasi Kerja Terhadap Kepuasan Kerja Karyawan (Studi Kasus Pada PT Inovasi Teknologi)
Authors: Darmawan Happy
Published: November 2018

The purpose of this study was to identify and analyze the influence of motivation kerjaterhadap leadership style and job satisfaction of employees at PT Technological Innovation. This research was conducted by tekknik simple random sampling (simple sampling technique), with a sample of 75 respondents. Entire multiple regression equation used meets the requirements of the classical assumption test. The results of this study indicate that there is a significant and positive influence between leadership style and motivation simultaneously on employee job satisfaction in PT Technological Innovation.
Pengaruh Kualitas Sistem, Kualitas Informasi, Penggunaan Sistem, Dan Kepuasan Pengguna Terhadap Dampak Individual (Studi Empiris Pada Bank Umum Di Jakarta)
Authors: Agustin Ekadjaja Ricche Khosasi,
Published: November 2018

The implementation of operational system is a necessity for the bank. However, the successful implementation of the system to the end-user of the systems have some little problems related to the end-user performance. The purpose of this research is to analyze and demonstrate empirically the effect of system quality, information quality, system use, and user satisfaction of the individual impact. The sample used by 75 respondents who were in the commercial bank in Jakarta. To answer the research hypothesis with IBM SPSS Statistic (Statistical Package for the Social Sciences) 21.0 software, multiple regression analysis is used in this test, after testing the assumption of classical test first. Based on the research results, it can be concluded that the system quality, information quality, system use, and user satisfaction have an effect to the individual impact. To get a better results, further research is recommended to add other variables to measure the effect of individual impact directly.
Pengaruh Kualitas Jasa Dengan Kepuasan Pelanggan Di RS Husada Jakarta
Authors: Utama Andyan Pradipta
Published: November 2018

The purpose of this study was to determine the relationship of service quality with patient satisfaction in Husada hospital Jakarta in order to provide a draft proposal regarding the quality of service in an effort to improve customer satisfaction. The variables of this study is the quality of service (independent variable) and customer satisfaction (dependent variable). Subjects were patients at the Husada hospital Jakarta totaling 100 patients were assigned to the non-probability sampling method accidental sampling. Measurements were made using a scale of Quality of Service which consists of 20 items, and Patient Satisfaction scale consisted of 12 items that are already on the validity and reliability. By using the technique of linear regression through SPSS for Windows version 21.0 was obtained in the regression R = 0.78 and R square = 0.609, p = 0.000 (p <0.05) indicating that patient satisfaction positively and significantly related to the quality of service equal to 0.780 and the role of service quality variables are able to explain the variable of 60.9% patient satisfaction. The study hypothesis which states "quality of care can improve patient satisfaction in Husada hospital Jakarta ", is accepted. Means the better the quality of service will be followed by increased patient satisfaction in Husada hospital Jakarta.
Kelas Sosial vs Pendapatan: Eksplorasi Faktor Penentu Pembelian Consumer Goods Dan Jasa
Authors: Triwijayati Anna
Published: November 2018

Social class and income influence consumer purchase behavior. This study aims to determine the relationship and difference between social class and income by purchasing consumer goods and services in Malang. This research used quantitative survey ex-post facto method. Research respondents were classified based on level of income and social class using the Index of Social Position (ISP). The quetionaire contaied 18 items of purchase, grouped into 5 types namely: food and drink, clothing, durable goods, investment, services and other products. Data analysis technique used chi-square. The results of the analysis show that the social class associate with the purchase of 17 items, while income associate with all items of goods and services consumed. Social class is more associated with fast food, clothes, electronic equipment, price and amount of investment and finance; income is more associated with meat, milk, the type of vehicle used, ownership of electronic tools, type of investment and finance, and housing and other buildings.
Pengaruh Current Ratio, Debt To Equity Ratio Dan Net Profit Margin Terhadap Earning Growth Pada Perusahaan Pertambangan Yang Tercatat Di Bursa Efek Indonesia
Authors: Zulkifli Zulkifli
Published: November 2018

This study aims to examine and analyze the effect of internal earning growth, annual data observation period 2012 until 2015. Type studies quantitative research. The population of all mining companies listed on the Indonesia Stock Exchange and consistently for four years amounted to 26 companies, with non-probability sampling technique is purposive sampling. Analysis data with panel data regression pooled the least square which has value adjusted r-squared 47.8% compared to other models. The results showed that current ratio (CR), debt to equity ratio (DER) and net profit margin (NPM) simultaneously are having the significant influence on the earnings growth. Partially, two variables are the current ratio, debt to equity ratio does not affect earnings growth. Meanwhile, NPM has a negative and significant effect on earning growth. Suggested adding variables external factors, using a sample of companies with other industries.