bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent
Authors: Zlatanova Hristina , Vladimirova Stanislava , Kostadinov Ilia , Delev Delian , Deneva Tanya , Kostadinova Ivanka
Published: April 2019

Background and objectives: The clinical use of non-steroidal anti-inflammatory drugs is limited due to high incidence of adverse drug reactions. The pyrrole heterocycle is included in the chemical structure of a number of drugs with various activities and shows relatively good tolerability and safety. The objectives of our study were to evaluate the analgesic and anti-inflammatory activity, as well as possible organ toxicity, of 2-[3-acetyl-5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-3-(1H-indol-3-yl)-propionic acid (compound 3g), a novel N-pyrrolylcarboxylic acid structurally similar to celecoxib. Materials and methods: All experiments were performed on 6-week-old male Wistar rats divided into parallel groups (n = 8). Antinociception was assessed using animal pain models with thermal and chemical stimuli (paw withdrawal, tail-flick, and formalin tests). Criteria for the analgesic effect were increased latency in the paw withdrawal and tail-flick tests and decreased paw licking time in the formalin test compared to animals treated with saline (control). Anti-inflammatory activity was measured using a carrageenan-induced paw edema model; the criterion for anti-inflammatory effect was decreased edema compared to control. Blood samples were obtained after animals were sacrificed to assess possible organ toxicity. Statistical analysis was performed with IBM SPSS 20.0. Results: 2-[3-Acetyl-5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-3-(1H-indol-3-yl)-propionic acid had analgesic action against chemical stimulus after single and multiple administration and against thermal stimulus after single administration. Compound 3g significantly suppressed carrageenan-induced paw edema after both single and continuous administration. After continuous administration, hematological tests showed that compound 3g decreased leukocyte and platelet levels and elevated serum creatinine levels. Conclusions: Antinociception with the tested compound is most likely mediated by spinal, peripheral, and anti-inflammatory mechanisms. Possible tolerance of the analgesic action at the spinal level develops after continuous administration. Anti-inflammatory activity is significant and probably the leading cause of antinociception. After multiple administration, compound 3g showed signs of potential nephrotoxicity and antiplatelet activity, as well as suppression of leukocyte levels.
Surgical Management of Chronic Rhinosinusitis in Cystic Fibrosis
Authors: Zheng Zhong , Safi Chetan , Gudis David A.
Published: April 2019

Cystic fibrosis patients frequently develop chronic rhinosinusitis as a result of their propensity to form inspissated mucus and impairment of mucociliary clearance. They exhibit variable symptom burden even in the setting of positive radiographic and endoscopic findings. Current evidence suggests a positive effect of managing sinonasal disease on pulmonary health. Topical antimicrobial and mucolytic therapies are frequently required to manage the disease with surgery reserved for refractory cases. Endoscopic sinus surgery has been demonstrated to be safe and efficacious in controlling symptoms of chronic rhinosinusitis in patients with comorbid cystic fibrosis. However, the impact of surgery on pulmonary health remains an active area of investigation. In addition, a growing body of research has suggested a more extended surgical approach creating large sinonasal cavities with gravity-dependent drainage pathways, followed by adjuvant medical therapies, as an ideal strategy to optimally control disease and prevent pulmonary exacerbations. In this manuscript, we provide an up-to-date review of current evidence in the surgical management of chronic rhinosinusitis in cystic fibrosis patients.
Inhibition of Satellite RNA Associated Cucumber Mosaic Virus Infection by Essential Oil of Micromeria croatica (Pers.) Schott
Authors: Vuko Elma , Rusak Gordana , Dunkić Valerija , Kremer Dario , Kosalec Ivan , Rađa Biljana , Bezić Nada
Published: April 2019

The present results dealing with the antiphytoviral activity of essential oil indicate that these plant metabolites can trigger a response to viral infection. The essential oil from Micromeria croatica and the main oil components β-caryophyllene and caryophyllene oxide were tested for antiphytoviral activity on plants infected with satellite RNA associated cucumber mosaic virus. Simultaneous inoculation of virus with essential oil or with the dominant components of oil, and the treatment of plants prior to virus inoculation, resulted in a reduction of virus infection in the local and systemic host plants. Treatment with essential oil changed the level of alternative oxidase gene expression in infected Arabidopsis plants indicating a connection between the essential oil treatment, aox gene expression and the development of viral infection.
Sex Differences in Plasma MicroRNA Biomarkers of Early and Complicated Diabetes Mellitus in Israeli Arab and Jewish Patients
Authors: Meerson Ari , Najjar Azwar , Saad Elias , Sbeit Wisam , Barhoum Masad , Assy Nimer
Published: April 2019

MicroRNAs play functional roles in the etiology of type 2 diabetes mellitus (T2DM) and complications, and extracellular microRNAs have attracted interest as potential biomarkers of these conditions. We aimed to identify a set of plasma microRNAs, which could serve as biomarkers of T2DM and complications in a mixed Israeli Arab/Jewish patient sample. Subjects included 30 healthy volunteers, 29 early-stage T2DM patients, and 29 late-stage T2DM patients with renal and/or vascular complications. RNA was isolated from plasma, and the levels of 12 candidate microRNAs were measured by quantitative reverse transcription and polymerase chain reaction (qRT-PCR). MicroRNA levels were compared between the groups and correlated to clinical measurements, followed by stepwise regression analysis and discriminant analysis. Plasma miR-486-3p and miR-423 were respectively up- and down-regulated in T2DM patients compared to healthy controls. MiR-28-3p and miR-423 were up-regulated in patients with complicated T2DM compared to early T2DM, while miR-486-3p was down-regulated. Combined, four microRNAs (miR-146a-5p, miR-16-2-3p, miR-126-5p, and miR-30d) could distinguish early from complicated T2DM with 77% accuracy and 79% sensitivity. In male patients only, the same microRNAs, with the addition of miR-423, could distinguish early from complicated T2DM with 83.3% accuracy. Furthermore, plasma microRNA levels showed significant correlations with clinical measurements, and these differed between men and women. Additionally, miR-183-5p levels differed significantly between the ethnic groups. Our study identified a panel of specific plasma microRNAs which can serve as biomarkers of T2DM and its complications and emphasizes the importance of sex differences in their clinical application.
Averaging Pixel Current Adjustment Technique for Reducing Fixed Pattern Noise in the Bolometer-Type Uncooled Infrared Image Sensor
Authors: Kim Sang-Hwan , Choi Byoung-Soo , Lee Jimin , Lee Junwoo , Lee Jewon , Park Jae-Hyoun , Lee Kyoung-Il , Shin Jang-Kyoo
Published: April 2019

In this paper, we propose an averaging pixel current adjustment technique for reducing fixed pattern noise (FPN) in the bolometer-type uncooled infrared image sensor. The averaging pixel current adjustment technique is composed of active pixel, reference pixel, and calibration circuit. Polysilicon resistors were used in each active pixel and reference pixel. Resistance deviation among active pixels integrated with the same resistance value cause FPN. The principle of the averaging pixel current adjustment technique for removing FPN is based on the subtraction of dark current of the active pixel from the dark current of the reference pixel. The subtracted current is converted into the voltage, which contains pixel calibration information. The calibration circuit is used to adjust the calibration current. After calibration, the nano-ampere current is output with small deviation. The proposed averaging pixel current adjustment technique is implemented by a chip composed of a pixel array, a calibration circuit, average current generators, and readout circuits. The chip was fabricated using a standard 0.35 μm CMOS process and its performance was evaluated.
The Validity and Reliability of a Kinect v2-Based Gait Analysis System for Children with Cerebral Palsy
Authors: Ma Yunru , Mithraratne Kumar , Wilson Nichola C. , Wang Xiangbin , Ma Ye , Zhang Yanxin
Published: April 2019

The aim of this study is to evaluate if Kinect is a valid and reliable clinical gait analysis tool for children with cerebral palsy (CP), and whether linear regression and long short-term memory (LSTM) recurrent neural network methods can improve its performance. A gait analysis was conducted on ten children with CP, on two occasions. Lower limb joint kinematics computed from the Kinect and a traditional marker-based Motion Analysis system were investigated by calculating the root mean square errors (RMSE), the coefficients of multiple correlation (CMC), and the intra-class correlation coefficients (ICC2,k). Results showed that the Kinect-based kinematics had an overall modest to poor correlation (CMC—less than 0.001 to 0.70) and an angle pattern similarity with Motion Analysis. After the calibration, RMSE on every degree of freedom decreased. The two calibration methods indicated similar levels of improvement in hip sagittal (CMC—0.81 ± 0.10 vs. 0.75 ± 0.22)/frontal (CMC—0.41 ± 0.35 vs. 0.42 ± 0.37) and knee sagittal kinematics (CMC—0.85±0.07 vs. 0.87 ± 0.12). The hip sagittal (CMC—0.97±0.05) and knee sagittal (CMC—0.88 ± 0.12) angle patterns showed a very good agreement over two days. Modest to excellent reliability (ICC2,k—0.45 to 0.93) for most parameters renders it feasible for observing ongoing changes in gait kinematics.
On the Combination of Multi-Cloud and Network Coding for Cost-Efficient Storage in Industrial Applications
Authors: Peralta Goiuri , Garrido Pablo , Bilbao Josu , Agüero Ramón , Crespo Pedro M.
Published: April 2019

The adoption of both Cyber–Physical Systems (CPSs) and the Internet-of-Things (IoT) has enabled the evolution towards the so-called Industry 4.0. These technologies, together with cloud computing and artificial intelligence, foster new business opportunities. Besides, several industrial applications need immediate decision making and fog computing is emerging as a promising solution to address such requirement. In order to achieve a cost-efficient system, we propose taking advantage from spot instances, a new service offered by cloud providers, which provide resources at lower prices. The main downside of these instances is that they do not ensure service continuity and they might suffer from interruptions. An architecture that combines fog and multi-cloud deployments along with Network Coding (NC) techniques, guarantees the needed fault-tolerance for the cloud environment, and also reduces the required amount of redundant data to provide reliable services. In this paper we analyze how NC can actually help to reduce the storage cost and improve the resource efficiency for industrial applications, based on a multi-cloud infrastructure. The cost analysis has been carried out using both real AWS EC2 spot instance prices and, to complement them, prices obtained from a model based on a finite Markov chain, derived from real measurements. We have analyzed the overall system cost, depending on different parameters, showing that configurations that seek to minimize the storage yield a higher cost reduction, due to the strong impact of storage cost.
Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase
Authors: Ahmad Norlaily , Colak Burcu , Zhang De-Wen , Gibbs Martin John , Watkinson Michael , Becer C. Remzi , Gautrot Julien E. , Krause Steffi
Published: April 2019

Peptide cross-linked poly(ethylene glycol) hydrogel has been widely used for drug delivery and tissue engineering. However, the use of this material as a biosensor for the detection of collagenase has not been explored. Proteases play a key role in the pathology of diseases such as rheumatoid arthritis and osteoarthritis. The detection of this class of enzyme using the degradable hydrogel film format is promising as a point-of-care device for disease monitoring. In this study, a protease biosensor was developed based on the degradation of a peptide cross-linked poly(ethylene glycol) hydrogel film and demonstrated for the detection of collagenase. The hydrogel was deposited on gold-coated quartz crystals, and their degradation in the presence of collagenase was monitored using a quartz crystal microbalance (QCM). The biosensor was shown to respond to concentrations between 2 and 2000 nM in less than 10 min with a lower detection limit of 2 nM.
Treatment of Tannery Wastewater with Vibratory Shear-Enhanced Processing Membrane Filtration
Authors: Zouboulis Anastasios I. , Peleka Efrosyni N. , Ntolia Anastasia
Published: April 2019

The performance of a vibratory shear-enhanced process (VSEP) combined with an appropriate membrane unit for the treatment of simulated or industrial tannery wastewaters was investigated. The fundamental operational and pollution parameters were evaluated, i.e., the membrane type, the applied vibration amplitude, as well as the removal rates (%) of tannins, chemical oxygen demand (COD), Ntotal, turbidity and color. Regarding the system’s treatment efficiency, specific emphasis was given towards the removal of organics (expressed as COD values), suspended solids (SS), conductivity (as an index of dissolved solids’ presence) and total nitrogen. The removal of organic matter in terms of COD exceeded 75% for all the examined cases. The quality of treated wastewater was affected not only by the membrane specific type (i.e., the respective pore diameters), but also by the applied vibration amplitude. Furthermore, an average 50% removal rate, regarding the aforementioned parameters, was observed both for the simulated and the industrial tannery wastewaters during the microfiltration (MF) experiments. That removal rate was further increased up to 85%, when ultrafiltration (UF) was applied, and up to 99% during the Reverse Osmosis (RO) experiments, considering the maximum applied vibration amplitude (31.75 mm).
The Impact of Incumbent Scandals on Senate Elections, 1972–2016
Authors: Long Nicholas Chad
Published: April 2019

In recent decades, a growing body of literature focused on the effects of scandals on congressional elections. The studies concluded that scandals decrease candidates’ vote totals, and that certain types of scandals have a more deleterious effect than others. Virtually all of these studies focus on House elections. The obvious differences between the two chambers calls into question the applicability of these findings for Senate elections. This study examines the impact that incumbent scandals had on senatorial elections from 1972 to 2016. Scandals are categorized based on the nature of the transgression in order to determine if the type of scandal made a difference. The results reveal that senators seeking reelection while confronting a scandal suffered a 4% decrease in the popular vote. Scandals involving political misdeeds, financial improprieties, and controversial statements hurt incumbents the most. Scandals also attracted challengers who spent more money against the incumbents.
Effects of a 2-km Swim on Markers of Cycling Performance in Elite Age-Group Triathletes
Authors: Rothschild Jeffrey , Crocker George H.
Published: April 2019

The purpose of this study was to examine the effects of a 2-km swim on markers of subsequent cycling performance in well-trained, age-group triathletes. Fifteen participants (10 males, five females, 38.3 ± 8.4 years) performed two progressive cycling tests between two and ten days apart, one of which was immediately following a 2-km swim (33.7 ± 4.1 min). Cycling power at 4-mM blood lactate concentration decreased after swimming by an average of 3.8% (p = 0.03, 95% CI −7.7, 0.2%), while heart rate during submaximal cycling (220 W for males, 150 W for females) increased by an average of 4.0% (p = 0.02, 95% CI 1.7, 9.7%), compared to cycling without prior swimming. Maximal oxygen consumption decreased by an average of 4.0% (p = 0.01, 95% CI −6.5, −1.4%), and peak power decreased by an average of 4.5% (p < 0.01, 95% CI −7.3, −2.3%) after swimming, compared to cycling without prior swimming. Results from this study suggest that markers of submaximal and maximal cycling are impaired following a 2-km swim.
A Dynamic Strategy for Home Pick-Up Service with Uncertain Customer Requests and Its Implementation
Authors: Wu Yu , Zeng Bo , Huang Siming
Published: April 2019

In this paper, a home service problem is studied, where a capacitated vehicle collects customers’ parcels in one pick-up tour. We consider a situation where customers, who have scheduled their services in advance, may call to cancel their appointments, and customers, who do not have appointments, also need to be visited if they request for services as long as the capacity is allowed. To handle those changes that occurred over the tour, a dynamic strategy will be needed to guide the vehicle to visit customers in an efficient way. Aimed at minimizing the vehicle’s total expected travel distance, we model this problem as a multi-dimensional Markov Decision Process (MDP) with finite exponential scale state space. We exactly solve this MDP via dynamic programming, where the computing complexity is exponential. In order to avoid complexity continually increasing, we aim to develop a fast looking-up method for one already-examined state’s record. Although generally this will result in a huge waste of memory, by exploiting critical structural properties of the state space, we obtain an O ( 1 ) looking-up method without any waste of memory. Computational experiments demonstrate the effectiveness of our model and the developed solution method. For larger instances, two well-performed heuristics are proposed.
"I am years seven old." Acquisition of English word order by Bosnian and Turkish children
Authors: Akbarov Azamat , Đapo Larisa
Published: April 2019

This paper aims to investigate differences in the acquisition of English word order between Bosnian and Turkish students resulting from word order in these two languages (Bosnian and Turkish). In second language acquisition, the knowledge of the native language (L1) in acquisition of a foreign language (L2) can indeed have a facilitating or inhibiting effect on the learner’s progress in mastering a new language. Thirty children from the first grade at the International School of Sarajevo were tested. Some of them attended the kindergarten where English was a language of communication and the rest of them had six months of exposure of English in school settings. We wanted to find possible differences in acquiring word order in English in these groups of children as well. This study offers new results for acquiring correct word order in English.
Clima organizacional y su influencia en el desempeño laboral del personal administrativo de los Distritos de salud pública de la provincia de Manabí-Ecuador
Authors: Palacios Molina Dayni Lisset
Published: April 2019

El clima organizacional y el desempeño laboral son variables que permiten lograr el éxito en las organizaciones, sobre ello muchos teóricos han generado sus aportes. Para esta investigación se planteó el objetivo de determinar la influencia del clima organizacional en el desempeño del personal administrativo de los distritos de salud de la provincia de Manabí. Se aplicaron 312 encuestas en las que se utilizaron dos instrumentos de medición, con un total de 98 items. El método de investigación es lógico inductivo, a través de la validación de una hipótesis general y cinco específicas, utilizando el software estadístico SPSS. La prueba de Alfa de Cronbach para validar el instrumento arrojó un 0.914, significando un alto nivel de confiabilidad en los datos recabados; el Rho de Spearman en la hipótesis general es de 0.234, evidenciando un nivel correlacional significativo; expresando que a mejor clima organizacional, mayor desempeño laboral.

 

Palabras clave: desempeño laboral, organización, empleados, evaluación del desempeño.

 

ABSTRACT

 

The organizational climate and work performance are variables that allow success in organizations, on this many theorists have generated their contributions. The objective of this research was to determine the influence of the organizational climate on the performance of the administrative staff of the health districts of the province of Manabí. 312 surveys were applied in which two measuring instruments were used, with a total of 98 items. The research method is logical inductive, through the validation of a general hypothesis and five specific ones, using the statistical software SPSS. The Cronbach’s Alpha test to validate the instrument yielded a 0.914, meaning a high level of reliability in the data collected; Spearman’s Rho in the general hypothesis is 0.234, evidencing a significant correlation level; Expressing that the better organizational climate, the higher job performance.

 

Key words: work performance, organization, employees, performance evaluation.
Kaizen en el gemba de jean para microempresas textiles cantón Pelileo
Authors: Miño Gloria Elizabeth , Moyano Alulema Julio César , García Flores Alcides Napoléon
Published: April 2019

La aplicación del Kaizen toma importancia en la gestión operativa, productiva de la empresa industrial moderna, debido a que se utiliza un conjunto de conceptos, técnicas y procedimientos que ayudan buscar el mejoramiento continuo, al ser las acciones diarias sencillas de todos los participantes que buscan la solución de los problemas, está filosofía busca reducir costos operativos para el mejoramiento productivo empresarial. Las actividades se realizan en el Gemba, término gerencial japonés utilizado para describir el puesto o lugar de trabajo (Work station), donde la productividad-competitividad tiene que ir unida a la calidad, obligando a todos los participantes a mejorar el trabajo en equipo en forma sistemática, para evitar las mudas, tiempos perdidos por excesivas esperas e incrementar el valor añadido al producto en elaboración, utilizando para aquello diagramas propios de estudio de trabajo, en especial el de análisis de procesos, recorrido para el mejoramiento productivo del antes y después de la confección textil en este caso pantalones jean´s, este tipo de prendas se realiza en la ciudad de Pelileo la cual no solo es comercializada en la misma, sino que es para la población a nivel nacional.

 

Palabras clave: kaizen, gemba, producción, productividad, optimización de la producción.
Rol gerencial en las juntas parroquiales rurales del Ecuador en la implementación de políticas públicas
Authors: Vera Montenegro Baly Ilovasky , Valarezo Beltrón Carlos Oswaldo , González Paris Evelyn
Published: April 2019

Este artículo tiene como objetivo determinar el rol gerencial de las autoridades seccionales en las juntas parroquiales rurales, relacionada con la implementación de políticas públicas, para lo cual se explora diversos conceptos sobre organización, su tipología, la gerencia, la interrelación de la gerencia en la implementación de política pública, también se analiza la toma de decisiones.

 

Palabras clave: implementacion, políticas públicas, rol, organizacion.
Underlying histopathology of peripheral nerve injury and the classical nerve repair techniques
Authors: Andrei Marin , Ioana Mihai Ruxandra , Mircea Enescu Dan
Published: April 2019

A much-debated subject in the last 20 years, the recovery after peripheral nerve injury still remains one of the most researched themes of our days. Although the central nervous system has not exhibited any ground-breaking discoveries in matters of healing through surgical procedures, this is not the case for the peripheral nervous system (PNS). The PNS recovery after injury has improved over the years so we now speak of time and percentage of rehabilitation. The increased interest for this subject is a result in the development of the medical technique, that allowed the creation of new molecules capable to improve the regeneration rate. Furthermore, the evolution in diagnostic parameters, as well as the possibility of a thorough follow-up, contributed to the ascending research of this field.  One must not forget that all experimental studies have as endpoint obtaining safe and reproducible solutions which can be applied in treating patients with peripheral nerve injury. We will briefly present the microscopic events that occur following a peripheral nerve injury, the key factors which influence their regeneration as well as the classical techniques used to repair them. However, the most intriguing topic in nerve regeneration is not related to the surgical procedure (considered to be the Gold Standard in whole nerve injury), but rather the helping substances that facilitate a faster and better recovery.
Ossification of the yellow ligament in thoracic spine: a case report
Authors: Azar Aydin Kazempour , Aghazadeh Javad , Salehpoor Firouz , Rezakhah Amir , Kamalifar Amir , Ramezanpour Saber , Kamalifar Samar
Published: April 2019

Ossifications of the yellow ligament (OYL) and calcification of yellow ligament are relatively rare clinical entities, and can make sever morbidity surgical evaluation can relived the sign and symptom and improve life quality we present a patient with ossification of the yellow ligament in level of T9 and T10 of thoracic spin.
Analisis Penetapan Nilai Jual Obyek Pajak Bumi dan Bangunan Sektor Perkebunan sebagai Upaya Peningkatan Sumber Pendapatan Daerah
Authors: Kadir Abdul
Published: April 2019

The purpose of this paper is to explore the sources of income from the plantation sector, through policies in the form of changes in determining the amount of Tax Object Sales Value, Land and Building Tax (PBB NJOP) based on macroeconomic variables and crop productivity as well as the effect on Regional Original Income (PAD ) This paper focuses on NJOP by using primary data to analyze stakeholder perceptions and secondary data for path equation analysis. The results showed that simultaneously the variables of economic growth and population density had a significant effect on NJOP at a 95% confidence level. Partially economic growth variables and population density have a significant effect on NJOP at a 95% confidence level. The ability of economic growth variables and population density together can provide an explanation of the NJOP variation of 38.70%. Together, the variables of economic growth, population density and NJOP have a significant effect on the United Nations at a 95% confidence level. Partially economic growth, population density and NJOP have a significant effect on the United Nations at a 95% confidence level. The ability of economic growth, population density and NJOP are jointly able to provide an explanation of the UN variation of 67.20%. Simultaneously the variables of economic growth, population density, NJOP and PBB significantly affected PAD at 95% confidence level. Partially, the variables of economic growth, population density, NJOP and PBB significantly affected PAD at 95% confidence level. Variables of economic growth, population density, NJOP and PBB together are able to provide an explanation of PAD variation of 67.70%.
ANALISIS HUBUNGAN ANTAR MANUSIA TERHADAP KINERJA KARYAWAN
Authors: Latief Abdul , Rosalina Dhian
Published: April 2019

Penelitian ini bertujuan untuk mengetahui pengaruh hubungan antar manusia terhadap kinerja karyawan PT Perkebunan Timbang Langsa. Penelitian ini merupakan jenis penelitian kuantitatif deskriptif dengan sampel sebanyak 134 responden. Teknik pengambilan sampel pada penelitian ini menggunakan Probability Sampling dan penentuan sampel dilakukan secara random sampling. Metode analisis data yang digunakan adalah analisis regresi linier sederhana. Uji hipotesis yang dilakukan melalui uji parsial (uji t) dan uji koefisien determinasi (R2). Hasil persamaan regresi diperolehY = 2,687 + 0,375X1.Nilai konstanta adalah sebesar 2,687 merupakan nilai kinerja karyawan sebelum dipengaruhi oleh hubungan antar manusia.Koefisien regresi hubungan antar manusia bernilai 0,375 dan bertanda positif, artinya apabila hubungan antar manusia ditingkatkan sebesar satu satuan maka kinerja karyawan akan meningkat sebesar 0,375. Hubungan antar manusia berpengaruh positif dan signifikan terhadap kinerja karyawan pada PT Perkebunan Timbang Langsa dengan hasil uji t yaitu nilai thitung> ttabel (5,573 > 1,656) dan nilai t sig yaitu 0,000 < 0,05. Nilai koefisien determinasi (R2) yaitu 0,19 0atau 19,0%. Hal ini menunjukkan variabel hubungan antar manusia mempengaruhi kinerja karyawan pada PT. Perkebunan Timbang Langsa sebesar 19,0%, dan sisanya 81,0% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini, seperti motivasi dan kompensasi.
Pengaruh Kuliah Kerja Nyata Mahasiswa Fakultas Ekonomi Universitas Samudra terhadap Pengembangan Kompetensi Sumber Daya Manusia
Authors: Syardiansah Syardiansah
Published: April 2019

This study was conducted to determine the effect of real work on the development of human resource competencies (students) at the Faculty of Economics at the University of Samudra who had attended real work classes in 2018. The number of respondents in this study was 150 students from the Management Study Program, Economics Level IV Development and Accounting Economics that has attended real work classes in 2018. Using the Slovin formula, there are 60 students as a sample. The data in this study were obtained from the results of distributing questionnaires to students as many as 60 questionnaires which were all returned without defects. From the results of data analysis, it was found that there were positive and significant influences on KKN on improving human resource competencies, namely personality competencies and social competencies. Where the coefficient of determination (R2) personality competence is 21.2% while the remaining 78.8% is influenced by other variables not examined in this study. The coefficient of determination (R2) of social competence is 21.4% while the remaining 78.6% is influenced by other variables not examined in this study
Kolaborasi Alat Musik Tradisional dan Alat Musik Modern dalam Mengiringi Ibadah Minggu di HKBP Tanjung Sari Medan
Authors: Simanjuntak Bella Cindy Juwita , Ginting Pulumun Peterus , Wiflihani Wiflihani
Published: April 2019

This study discusses the collaboration of traditional musical instruments and modern musical instruments in accompanying Sunday services at HKBP Tanjung Sari Medan. The purpose of this study was to find out the background and process of collaboration of traditional musical instruments and modern musical instruments in the HKBP Tanjung Sari church in Medan. The method used in this study is qualitative descriptive. The location of the study was carried out at the Tanjung Sari HKBP church, Jl. Setia Budi No. 11, Medan. The population of this study is traditional musical instruments and modern musical instruments used in accompanying Sunday services at HKBP Tanjung Sari Medan. While the samples in this study were Taganing, drums, keyboards, acoustic guitars, bass guitars, saxophone which were used to accompany Sunday services at HKBP Tanjung Sari Medan. The data collection technique is through observation, interviews, documentation, and library studies. Based on the results of the study, it can be seen that traditional musical instruments and modern musical instruments used in accompanying Sunday services at HKBP Tanjung Sari Medan, namely: Taganing, drums, keyboards, acoustic guitars, bass guitars, saxophone. The songs used in accompanying Sunday Service at HKBP Tanjung Sari Medan, and the collaboration process of traditional musical instruments and modern musical instruments in the HKBP Tanjung Sari church in Medan.
GAMBARAN POLA MAKAN SEBAGAI PENYEBAB KEJADIAN PENYAKIT TIDAK MENULAR (DIABETES MELLITUS, OBESITAS, DAN HIPERTENSI) DI WILAYAH KERJA PUSKESMAS CEBONGAN, KOTA SALATIGA
Authors: Nugroho Kristiawan P. A. , Kurniasari R. Rr Maria Dyah , Noviani Tabita
Published: April 2019

Gaya hidup manusia akibat adanya urbanisasi, modernisasi, dan globalisasi menjadi salah satu penyebab terjadinya peningkatan Penyakit Tidak Menular (PTM). Secara umum PTM seperti obesitas, Diabetes Mellitus (DM) dan hipertensi menjadi salah satu penyebab utama kematian secara global. Berdasarkan data kegiatan Posyandu di Puskesmas Cebongan, Kota Salatiga pada bulan Maret-April 2018, terdapat sebanyak 75 responden lansia dengan kasus non komplikasi (hipertensi dan DM), serta kasus komplikasi (hipertensi dan DM, hipertensi dan obesitas, DM dan obesitas, serta hipertensi, DM, dan obesitas). Penelitian bertujuan untuk mengetahui gambaran penyebab kejadian PTM dari sudut pandang gaya hidup, terutama pola makan. Metode yang digunakan adalah deskriptif kuantitatif, dengan instrumen pengambilan data berupa Food Frequency Questionnaire (FFQ) dan Food Recall. Hasil penelitian menunjukkan bahwa, kecenderungan konsumsi karbohidrat yang tinggi mencapai 13,81 kali per minggu berpeluang menimbulkan penyakit hipertensi. Serta tingkat asupan gizi defisit berat pada asupan energi dan karbohidrat ada kaitannya dengan kadar gula darah yang tidak terkontrol. Kejadian hipertensi dan DM dipengaruhi oleh pola makan, sedangkan obesitas dikarenakan proses fisiologis lansia yaitu kehilangan massa otot sehingga menyebabkan berkurangnya pemakaian energi dan menumpuknya jaringan lemak.

Kata kunci : diabetes mellitus, obesitas, hipertensi, lansia, pola makan, Salatiga

Human lifestyle due to urbanization, modernization, and globalization to be one cause of the increase of Non-communicable diseases (PTM). In general, PTM such as obesity, Diabetes Mellitus (DM) and hypertension become one of the main causes of death globally. Based on data of Posyandu activity at Puskesmas Cebongan, Salatiga City, March-April 2018, there were 75 elderly respondents with non complicated cases (hypertension and DM), and complication cases (hypertension and DM, hypertension and obesity, DM and obesity, and hypertension , DM, and obesity). This study aims to determine the description of the causes of the incidence of PTM from the point of view of lifestyle, especially diet. The method used is descriptive quantitative, with data collection instrument in the form of Food Frequency Questionnaire (FFQ) and Food Recall. The results showed that, the tendency of high carbohydrate consumption reached 13.81 times per week potentially cause hypertension disease. As well as the level 16 Jurnal Kesehatan Kusuma Husada - Januari 2019 of intake of heavy nutritional deÞ cit in energy and carbohydrate intake is related to uncontrolled bloodsugar levels. The incidence of hypertension and DM is inß uenced by diet, while obesity is due to the elderly physiological process of losing muscle mass resulting in reduced energy consumption and fat tissue accumulation.

Keywords: diabetes mellitus, obesity, hypertension, elderly, diet, Salatiga
FAKTOR RISIKO PENYEBAB KEJADIAN HIPERTENSI DI WILAYAH KERJA PUSKESMAS SIDOREJO LOR KOTA SALATIGA
Authors: Nugroho Kristiawan P.A. , Sanubari Theresia P.E. , Rumondor Jein Mayasari
Published: April 2019

Hipertensi merupakan Penyakit Tidak Menular (PTM) yang merupakan masalah utama dalam kesehatan masyarakat di Indonesia maupun dunia. Data ProÞ l Kesehatan Kota Salatiga 2014 menyatakan bahwa PTM yang banyak ditemukan di Kota Salatiga adalah hipertensi yaitu sebanyak 62%. Data penderita hipertensi di Puskesmas Sidorejo Lor selama 2 tahun terakhir tercatat sebanyak 319 kasus (2016) dan sebanyak 256 kasus sampa i dengan pertengahan tahun 2017. Tujuan penelitian adalah untuk mengetahui gambaran faktor-faktor yang mempengaruhi perilaku makan penderita hipertensi di wilayah kerja Puskesmas Sidorejo Lor. Metode penelitian menggunakan metode survei observasional dengan pengambilan data yang berupa kuisioner dengan menggunakan jenis penelitian deskriptif kuantitatif. Data yang diperoleh dianalisis menggunakan analisis univariat dan bivariat atau uji korelasi.

Kata kunci : perilaku makan, hipertensi, faktor risiko

Hypertension is a non-communicable disease (PTM) which is a major problem in public health in Indonesia and the world. Data health proÞ le of the city of Salatiga in 2014 states that non-communicable disease are commonly found in the city of Salatiga is hypertension as much as 62 percent. Data of hypertension patients at Puskesmas Sidorejo Lor during the last 2 years were recorded as many as 319 cases in 2016 dan as many as 256 cases until mid 2017. The purpose of this study was to determine the description of factors that inß uence feeding behavior of hypertension patients in the work area of Puskesmas Sidorejo Lor. This research method using observational survey method with taking data in the form of interviews and questionnaires using quantitative deskriptive research type. The data obtained were analyzed using univariate and bivariate analysis or correlation test.

Key Words : eating behavior, hypertension, risk factors
UJI DAYA HAMBAT EKSTRAK ETANOL DAUN SRIKAYA (Annona squamosa L.) TERHADAP PERTUMBUHAN Staphylococcus aureus SECARA IN VITRO
Authors: Dewangga Vector Stephen , Nirwana Ardy Prian
Published: April 2019

Staphylococcus aureus merupakan salah satu bakteri penyebab bakteremia. Bakteremia dapat diatasi dengan menggunakan pengobatan tradisional yang lebih aman, salah satu alternatifnya dengan menggunakan daun Annona squamosa L. Tujuan penelitian adalah untuk mengetahui daya hambat ekstrak etanol daun A. squamosa L. dan mengetahui konsentrasi optimal dari ekstrak etanol daun A. squamosa L. dalam menghambat pertumbuhan S. aureus. Penelitian menggunakan desain analitik eksperimental dengan pendekatan Post Test with Control. Penelitian dilakukan di Laboratorium Bakteriologi STIKES Nasional Surakarta pada bulan Februari hingga Mei 2018. Sampel penelitian adalah ekstrak etanol daun A. squamosa L. dengan konsentrasi 12,5%, 25% dan 50%. Teknik sampling yang digunakan adalah quota sampling. Hipotesis dilakukan dengan One-way Anova, dilanjutkan uji Post Hoc dengan metode Duncan’s Multiple Range Test. Dari penelitian dijumpai diameter zona radikal 8,17 mm pada konsentrasi 12,5%; 9,57 mm pada konsentrasi 25%, dan 10,58 mm pada konsentrasi 50%. Uji Anova diperoleh hasil signiÞ kan yang artinya terdapat beda nyata diantara semua perlakuan. Ekstrak etanol daun A. squamosa L. mampu menghambat pertumbuhan S. aureus, namun belum seoptimal ciprofloxacin.

Kata kunci: Uji daya hambat, ekstrak etanol, daun Annona squamosa L., Staphylococcus aureus, ciprofloxacin

Staphylococcus aureus is one of bacteria that can cause bacterimia. Bacterimia can be prevented with traditional medicine which is safer, one of which is using the leaves of Annona squamosa L. The purpose of this research is to discover the inhibition test of ethanol extract of A. squamosa L. leaves and knowing the optimal concentration of ethanol extracts with A. squamosa L. leaves in inhibiting the growth of S. aureus. This study is an analytic experimental design and post test with control. The research was done during February to May 2018 at Bacteriological Laboratory of STIKES Nasional. The sample of this research is ethanol extract of A. squamosa L. leaves in 12,5%, 25%, and 50% concentration. Hypothesis test is done with One-way Anova, post hoc test followed by Duncan’s Multiple Range Test method. The result of this study has been found radical zone diameter in 12,5%, 25%, 50% concentration are 8,77 mm, 9,57 mm, 10,58 mm. The result Anova test is found to be signiÞ cant, which means there is real difference between all variance treatment. Ethanol extract of A. squamosa L. leaves has inhibition power against the growth of S. aureus with well diffusion method. Although there is no concentration more optimal than positive control (ciprofloxacin).

Keywords: Inhibition test, ethanol extract, Annona squamosa L. leaves, Staphylococcus aureus, ciprofloxacin.
PENGARUH SENAM HIPERTENSI TERHADAP PENURUNAN TEKANAN DARAH DI DESA BLEMBEM WILAYAH KERJA PUSKESMAS GONDANGREJO
Authors: Safitri Wahyuningsih , Astuti Hutari Puji
Published: April 2019

ABSTRAK

Gaya  hidup  masyarakat  yang  lebih  seperti  makanan  cepat  saji,  dapat  menyebabkan  berbagai masalah kesehatan termasuk hipertensi, gagal jantung, diabetes mellitus, stroke, dan penyakit ginjal. Hipertensi merupakan masalah kesehatan yang dialami oleh banyak orang tua. Salah satu cara untuk mencegah komplikasi hipertensi tidak terjadi dapat diberikan senam tindakan hipertensi. Penelitian ini berjudul pengaruh senam hipertensi terhadap penurunan tekanan darah di Blembem Desa Puskesmas Gondangrejo. Tujuan dari penelitian ini untuk mengetahui pengaruh senam hipertensi terhadap penurunan tekanan darah di Desa Blembem Puskesmas Gondangrejo. Metode penelitian adalah pre- eksperimen dengan satu kelompok pre-test dan desain post-test. Pengumpulan data dilakukan pada saat sebelum dan sesudah diberikan intervensi senam hipertensi latihan. Sampling dengan purposive sampling dan sampel beberapa 40 orang. Alat penelitian ini terdiri sphygmomanometer, stetoskop dan tekanan darah lembar observasi tekanan darah pre test dan post test. Analisis data menggunakan uji Wilcoxon. Hasil penelitian menunjukkan tidak ada efek senam hipertensi untuk pengurangan tekanan darah di Desa Blembem Puskesmas Gondangrejo dengan nilai p 0.000. Berdasarkan hasil penelitian senam hipertensi dapat digunakan sebagai informasi dan pertimbangan dalam memilih intervensi untuk orang tua yang memiliki hipertensi.

 

Kata kunci: hipertensi, lansia, senam hipertensi

 

 

ABSTRACT

People’s lifestyles are more like fast food, can cause a variety of health problems include hypertension, heart failure, diabetes mellitus, stroke and kidney disease. Hypertension is a health problem experienced by many elderly people. One way to prevent complications of hypertension does not occur can be given action gymnastics hypertension. This study titled gymnastics effect of hypertension on blood pressure reduction in Blembem Village Puskesmas Gondangrejo. The purpose of the study to determine the effect of exercise hypertension to the reduction of blood pressure in the Village Puskesmas Blembem Gondangrejo. The research method is pre-experiment with one group pre-test and post-test design. Data collection is done at the time before and after the exercise intervention hypertension. Sampling with purposive sampling and sample some 40 people. The research tool consists sphygmomanometer, stethoscope and blood pressure observation sheet pre test and post test. Data analysis using Wilcoxon test. Results showed no effect of exercise hypertension to the reduction of blood pressure in the Village Puskesmas Blembem Gondangrejo with p value 0.000. Based on the research results gymnastics hypertension can be used as an information and considerations in choosing interventions for elderly people who have hypertension.

 

Keywords: hypertension, elderly, hypertension gymnastics
HUBUNGAN KECEMASAN DENGAN KUALITAS HIDUP PASIEN POST CORONARY ARTERY BAYPASS GRAFT (CABG) DI RUANG REHABILITASI JANTUNG RUMAH SAKIT JANTUNG DAN PEMBULUH DARAH HARAPAN KITA JAKARTA
Authors: Awaludin Sidik , Afni Anissa Cindy Nurul , Sekarwati Wiwik
Published: April 2019

ABSTRAK Penyakit jantung koroner merupakan penyebab kematian terbesar di dunia. Penatalaksanaannya diantaranya dengan pembedahan seperti Coronarry Artery Bypass Graft (CABG). Tindakan CABG dapat menimbulkan kecemasan disetiap tahapannya. Kecemasan dapat menjadi hambatan penyesuaian psikologis pada pasien jantung dan akan menghambat pemulihan fisik yang berdampak pada kualitas hidup. Tujuan penelitian ini untuk mengetahui hubungan kecemasan dengan kualitas hidup pasien post CABG. Penelitian ini dilakukan di Ruang Rehabilitasi Jantung Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita Jakarta. Desain penelitian Desain penelitian ini yaitu cross sectional dengan jumlah sampel 25 pasien. Teknik sampling menggunakan consecutive sampling. Hasil penelitian ini ada hubungan yang bermakna antara kecemasan dan kualitas hidup pasien post CABG di Ruang Rehabilitasi Jantung RSJPD Harapan Kita Jakarta (p value 0.001).   Kata kunci: CABG, kecemasan, kualitas hidup     ABSTRACT Coronary heart diseases is the biggest cause of death in the world. One of its management is by surgery such as Coronarry Artery Bypass Graft (CABG). CABG prosedure can cause anxiety at every stage. Anxiety can be a barrier to psychological adjustment in heart patients and will inhibit physical recovery that impact on quality of life. The purpose of this study to determine the relationship of anxiety with the quality of life of post-CABG patients. The study was conducted in the heart hehabilitation room of RSJPD Harapan Kita. Research design of this study is cross sectional with a sample of 25 patients. The sampling technique uses consecutive sampling. The results of this study there is a significant relationship between anxiety and quality of life of post-CABG patients in the heart rehabilitation room RSJPD Harapan Kita Jakarta (p value 0.001).   Keywords: CABG, anxiety, quality of life
Étude structurale de Zn Ge N2
Authors: Maunaye Marcel , L'Haridon Paul , Laurent Yves , Lang Jean
Published: April 2019

ZnGeN₂ has a structure derived from that of wurtzite with the atoms of zinc and germanium randomly distributed among the zinc positions in ZnS.

The monoclinic unit cell dimensions are : a = 3.16₇ ; b = 5.19₄ ; c = 3.16₇ Å and β = 118° 53'. The space group is P2[r] with one formula unit per unit cell.

Since the metal atoms are disordered, ZnGeN₂ is quite different from other nitrides of the same type such as BeSiN₂, MgSiN₂ and MgGeN₂.
Entropie de configuration, solution solide et structure cristalline
Authors: Brown William Lidlle
Published: April 2019

The equation for calculating the configurational entropy of disordered solid solutions as the sum of the contributions of each site is applied to the orthopyroxenes and the plagioclases. The ideal configurational entropy is not equivalent to but always less than the entropy of mixing of real solution, provided there is no short distance order.
Étude micrographique des minéralisations de Pierrefitte (Hautes-Pyrénées)
Authors: Besson Maurice , Permingeat François , Picot Paul
Published: April 2019

L'étude de sections polies du minerai plombo˗zincifère de Pierrefitte montre que ce gisement présente une riche paragenèse comportant, essentiellement par ordre d'abondance : pyrrhotite, blende (sphalérite), magnétite, galène, chalcopyrite, mispickel (arsenopyrite), cobaltite, gersdorffite, loellingite, safflorite, rammelsbergite, nickeline, gudmundite, breithauptite, ullmannite, or natif, mackinawite, cubanite, chacolpyrrhotite, cuivre gris, dyscrasite, freieslebenite, pyrargyrite, proustite, pyrite et spinelle, plus de l'ilménite et du rutile dans la gangue. Nombre de ces minéraux sont signalés pour la première fois dans le gisement : plusieurs fournissent des indications sur les températures de formation. L'ordre de succession paragénétique et les rapports mutuels sont examinés.
« Pluton » : description d'un nouvel autoclave basé sur des phénomènes de convection. Premiers résultats dans le domaine des solubilités et des synthèses minérales
Authors: Deschamps J. , Goñi Juan C. , Guillemin Claude , Leleu Michel , Vannier Michel
Published: April 2019

A new apparatus is described which permits studies of mineral solubility and mineral paragenesis using various aqueous solutions up to 350° C temperature and 350 bars pressure.

The apparatus is composed of a tubular frame in which an aqueous solution flows from a hot to a cold zone. The solution composition is known at the beginning of the experiment. Minerals studied are dissolved in the hot zone and redeposited in the cooling area.

First results concern sphalerite and galena synthesis.