bluuebunny/crossref_metadata_2025 huggingface dataset:
Rituximab Induced Pulmonary Edema Managed with Extracorporeal Life Support
Authors: Miller Jacob R. , Isakow Warren , Masood Muhammad F. , Aguilar Patrick , Sanfilippo Kristen M. , Balsara Keki R. , Itoh Akinobu
Published: January 2018

Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after rituximab infusion. Despite advanced ventilatory settings, she developed severe respiratory acidosis and remained hypoxemic with a significant vasopressor requirement. Since her pulmonary insult was likely transient, ECLS was considered. Due to combined cardiorespiratory failure, she received support with peripheral venoarterial ECLS. During her ECLS course, she received daily plasmapheresis and high dose steroids. Her pulmonary function recovered and she was decannulated after 8 days. She was discharged after 23 days without residual sequelae.
A Case of Fibrous Pseudotumor in the Scrotum: Challenge for Diagnosis and Testicular Preservation
Authors: Kodama Hirotake , Hatakeyama Shingo , Matsumoto Teppei , Tanaka Toshikazu , Horiguchi Hirotaka , Kubota Yuka , Yamamoto Hayato , Imai Atsushi , Yoneyama Takahiro , Hashimoto Yasuhiro , Koie Takuya , Ohyama Chikara
Published: January 2018

A paratesticular fibrous pseudotumor is a relatively rare benign disease. Preoperatively diagnosing a fibrous pseudotumor is challenging because distinguishing these masses from malignant tumors on the basis of clinical and radiological findings can be difficult. We present a case of a 28-year-old man who presented with a painless palpable mass in the right scrotum; the fibrous pseudotumor of the tunica vaginalis was treated with organ-sparing surgery. Computed tomography and magnetic resonance imaging revealed paratesticular tumors. Testicular tumor marker levels were within normal limits. We scheduled the patient to undergo tumor biopsy combined with intraoperative rapid diagnosis. Frozen section assessment suggested a fibrous pseudotumor without malignancy. We successfully performed organ-sparing surgery. Testicular-sparing surgery combined with frozen section assessment is primarily used for treating paratesticular fibrous pseudotumors.
Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?
Authors: Yanto Theo Audi , Huang Ian , Kosasih Felicia Nathania , Lugito Nata Pratama Hardjo
Published: January 2018

Background. Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation. Herein we present a case of 56-year-old male patient with no known history of recurrent nightmares and sleep disorder, experiencing nightmare and abnormal dreams directly after consumption of 750 mg extended release metformin. He reported his dream as an unpleasant experience which awakened him at night with negative feelings. The nightmare only lasted for a night, but his dreams every night thereafter seemed abnormal. The dreams were vivid and indescribable. The disappearance and occurrence of abnormal dreams ensued soon after the drug was discontinued and rechallenged. The case was assessed using Naranjo Adverse Drug Reaction (ADR) probability scale and resulted as probable causality. Conclusion. Metformin might be the underlying cause of nightmare and abnormal dreams in this patient. More studies are needed to confirm the association and causality of this findings.
Advanced Effect of Moringa oleifera Bioconversion by Rhizopus oligosporus on the Treatment of Atopic Dermatitis: Preliminary Study
Authors: Hur Sang-sun , Choi Suk-won , Lee Dong-ryul , Park Jong-hwan , Chung Tae-ho
Published: January 2018

This study was conducted to determine if topical application of Moringa oleifera extracts and its bioconversion product fermented by Rhizopus oligosporus has therapeutic properties enhancement for treatment of atopic dermatitis. Rhizopus oligosporus (KCCM 11232P) was used to ferment Moringa leaves’ extracts in this study. Comparison of organic acids and flavonols in Moringa simple extracts and their fermented product by HPLC analysis revealed that concentration of organic acids and flavonols of bioconversion product was lower than that of hot water extracts. The fermentation process is used as a nutrient for isolation of each component by microorganisms and growth of microorganisms. The results demonstrated that MF extracts effectively reduced clinical features based on macrography, scratching count, and severity scores, as well as model’s serum IgE level, including histopathological analyses.
Theoretical 3D Model for Quasistatic Critical Derailment Coefficient of Railway Vehicles and a Simplified Formula
Authors: Wang Ping , Wang Jian , Ma Xiaochuan , Ma Daolin , Xu Jingmang , Qian Yao
Published: January 2018

The formula for the critical derailment coefficient concerning wheelset yaw angles and wheel-rail creep forces is deduced based on the three-dimensional (3D) force equilibrium relationship in the critical wheel derailment state under quasistatic assumption. The change of critical derailment coefficient and wheel-rail contact patch normal force/creep force as wheelset yaw angles change under the influence of the friction coefficient, maximum flange angle, and net wheel weight is analyzed according to the Kalker linear creep theory and Shen-Hedrick-Elkins creep theory. Analysis shows that the wheel-rail friction coefficient and maximum wheel flange contact angle can significantly influence the critical wheel derailment coefficient, further proving the conservative results when the critical Nadal derailment coefficient is adopted in analyzing wheel derailment under small wheelset yaw angles. To realize easy calculation and application of critical 3D derailment coefficients, the ratio of lateral creep force to longitudinal creep force of wheel-rail contact patches under critical quasistatic wheel derailment conditions is deduced. A simplified calculation method of critical derailment coefficients is presented based on this. The calculation accuracy is verified, proving that it can satisfy engineering application.
Biochemical Stimulus-Based Strategies for Meniscus Tissue Engineering and Regeneration
Authors: Chen Mingxue , Guo Weimin , Gao Shunag , Hao Chunxiang , Shen Shi , Zhang Zengzeng , Wang Zhenyong , Wang Zehao , Li Xu , Jing Xiaoguang , Zhang Xueliang , Yuan Zhiguo , Wang Mingjie , Zhang Yu , Peng Jiang , Wang Aiyuan , Wang Yu , Sui Xiang , Liu Shuyun , Guo Quanyi
Published: January 2018

Meniscus injuries are very common and still pose a challenge for the orthopedic surgeon. Meniscus injuries in the inner two-thirds of the meniscus remain incurable. Tissue-engineered meniscus strategies seem to offer a new approach for treating meniscus injuries with a combination of seed cells, scaffolds, and biochemical or biomechanical stimulation. Cell- or scaffold-based strategies play a pivotal role in meniscus regeneration. Similarly, biochemical and biomechanical stimulation are also important. Seed cells and scaffolds can be used to construct a tissue-engineered tissue; however, stimulation to enhance tissue maturation and remodeling is still needed. Such stimulation can be biomechanical or biochemical, but this review focuses only on biochemical stimulation. Growth factors (GFs) are one of the most important forms of biochemical stimulation. Frequently used GFs always play a critical role in normal limb development and growth. Further understanding of the functional mechanism of GFs will help scientists to design the best therapy strategies. In this review, we summarize some of the most important GFs in tissue-engineered menisci, as well as other types of biological stimulation.
Chronological Progression of an Enlarged Styloid Process: A Case Report of Eagle Syndrome
Authors: Maki Daisuke , Okami Kenji , Ebisumoto Koji , Sakai Akihiro
Published: January 2018

Eagle syndrome is characterized by an elongated styloid process. However, the time frame over which the styloid process becomes elongated and extends is unknown. How the condition worsens over time is also unclear. To date, there has been no report describing the chronologic change that occurs in the styloid process in Eagle syndrome. We describe a 53-year-old patient with Eagle syndrome in whom the styloid process enlarged progressively over time and the elongated styloid process fused with the hyoid bone. The styloid process was resected via a transcervical approach, and the patient’s subjective symptoms improved. This is the first report showing how the styloid process can enlarge over a few years in a patient with Eagle syndrome. Surgical resection via a transcervical approach is an appropriate treatment for a patient in whom the styloid process has become excessively enlarged and elongated.
Diclofenac Potassium in Acute Postoperative Pain and Dysmenorrhoea: Results from Comprehensive Clinical Trial Reports
Authors: Moore R. Andrew , Derry Sheena
Published: January 2018

We compared the efficacy of diclofenac potassium in unpublished clinical study reports (CSRs) and published reports to examine publication bias, industry bias, and comprehensiveness. Novartis provided CSRs of randomised double-blind trials of diclofenac potassium involving postoperative patients following third molar extraction (3 trials, n=519), gynaecological surgery (3 trials, n=679), and dysmenorrhoea (2 trials, n=711) conducted in 1988–1990. Searches identified published reports of 6 trials. Information from 599/1909 patients was not published; trials with 846/1909 patients were published in a defunct journal. Greater methodological information in CSRs contributed to lesser risk of bias than published trials. Numbers needed to treat (NNT) from CSRs for all six postoperative trials for at least 50% of maximum pain relief over 6 h were 2.2 (95% confidence interval, 1.9–2.6) and 2.1 (1.8–2.4) for 50 and 100 mg diclofenac potassium, respectively. A Cochrane review of published trial data reported NNTs of 2.1 and 1.9, and one comprehensive analysis reported NNTs of 2.2 and 2.1, respectively. All analyses had similar results for patients remedicating within 8 h. No data from dysmenorrhoea CSRs appeared in a Cochrane review. CSRs provide useful information and increase confidence. Stable efficacy estimates with standard study designs reduce the need for updating reviews.
Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival
Authors: Bien-Möller Sandra , Balz Ellen , Herzog Susann , Plantera Laura , Vogelgesang Silke , Weitmann Kerstin , Seifert Carolin , Fink Matthias A. , Marx Sascha , Bialke Angela , Venugopal Chitra , Singh Sheila K. , Hoffmann Wolfgang , Rauch Bernhard H. , Schroeder Henry W. S.
Published: January 2018

Patients with glioblastoma multiforme (GBM) are at high risk to develop a relapse despite multimodal therapy. Assumedly, glioma stem cells (GSCs) are responsible for treatment resistance of GBM. Identification of specific GSC markers may help to develop targeted therapies. Here, we performed expression analyses of stem cell (ABCG2, CD44, CD95, CD133, ELF4, Nanog, and Nestin) as well as differentiation and microglia markers (GFAP, Iba1, and Sparc) in GBM compared to nonmalignant brain. Furthermore, the role of these proteins for patient survival and their expression in LN18 stem-like neurospheres was analyzed. At mRNA level, ABCG2 and CD95 were reduced, GFAP was unchanged; all other investigated markers were increased in GBM. At protein level, CD44, ELF4, Nanog, Nestin, and Sparc were elevated in GBM, but only CD133 and Nestin were strongly associated with survival time. In addition, ABCG2 and GFAP expression was decreased in LN18 neurospheres whereas CD44, CD95, CD133, ELF4, Nanog, Nestin, and Sparc were upregulated. Altogether only CD133 and Nestin were associated with survival rates. This raises concerns regarding the suitability of the other target structures as prognostic markers, but makes both CD133 and Nestin candidates for GBM therapy. Nevertheless, a search for more specific marker proteins is urgently needed.
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Authors: Shao Wenlin , Mishina Yuji M. , Feng Yun , Caponigro Giordano , Cooke Vesselina G. , Rivera Stacy , Wang Yingyun , Shen Fang , Korn Joshua M. , Mathews Griner Lesley A. , Nishiguchi Gisele , Rico Alice , Tellew John , Haling Jacob R. , Aversa Robert , Polyakov Valery , Zang Richard , Hekmat-Nejad Mohammad , Amiri Payman , Singh Mallika , Keen Nicholas , Dillon Michael P. , Lees Emma , Ramurthy Savithri , Sellers William R. , Stuart Darrin D.
Published: January 2018

Resistance to the RAF inhibitor vemurafenib arises commonly in melanomas driven by the activated BRAF oncogene. Here, we report antitumor properties of RAF709, a novel ATP-competitive kinase inhibitor with high potency and selectivity against RAF kinases. RAF709 exhibited a mode of RAF inhibition distinct from RAF monomer inhibitors such as vemurafenib, showing equal activity against both RAF monomers and dimers. As a result, RAF709 inhibited MAPK signaling activity in tumor models harboring either BRAFV600 alterations or mutant N- and KRAS-driven signaling, with minimal paradoxical activation of wild-type RAF. In cell lines and murine xenograft models, RAF709 demonstrated selective antitumor activity in tumor cells harboring BRAF or RAS mutations compared with cells with wild-type BRAF and RAS genes. RAF709 demonstrated a direct pharmacokinetic/pharmacodynamic relationship in in vivo tumor models harboring KRAS mutation. Furthermore, RAF709 elicited regression of primary human tumor–derived xenograft models with BRAF, NRAS, or KRAS mutations with excellent tolerability. Our results support further development of inhibitors like RAF709, which represents a next-generation RAF inhibitor with unique biochemical and cellular properties that enables antitumor activities in RAS-mutant tumors.

Significance: In an effort to develop RAF inhibitors with the appropriate pharmacological properties to treat RAS mutant tumors, RAF709, a compound with potency, selectivity, and in vivo properties, was developed that will allow preclinical therapeutic hypothesis testing, but also provide an excellent probe to further unravel the complexities of RAF kinase signaling. Cancer Res; 78(6); 1537–48. ©2018 AACR.
Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer
Authors: Muliaditan Tamara , Opzoomer James W. , Caron Jonathan , Okesola Mary , Kosti Paris , Lall Sharanpreet , Van Hemelrijck Mieke , Dazzi Francesco , Tutt Andrew , Grigoriadis Anita , Gillett Cheryl E. , Madden Stephen F. , Burchell Joy M. , Kordasti Shahram , Diebold Sandra S. , Spicer James F. , Arnold James N.
Published: January 2018

Purpose: Unprecedented clinical outcomes have been achieved in a variety of cancers by targeting immune checkpoint molecules. This preclinical study investigates heme oxygenase-1 (HO-1), an immunosuppressive enzyme that is expressed in a wide variety of cancers, as a potential immune checkpoint target in the context of a chemotherapy-elicited antitumor immune response. We evaluate repurposing tin mesoporphyrin (SnMP), which has demonstrated safety and efficacy targeting hepatic HO in the clinic for the treatment of hyperbilirubinemia, as an immune checkpoint blockade therapy for the treatment of cancer.

Experimental Design: SnMP and genetic inactivation of myeloid HO-1 were evaluated alongside 5-fluorouracil in an aggressive spontaneous murine model of breast cancer (MMTV-PyMT). Single-cell RNA sequencing analysis, tumor microarray, and clinical survival data from breast cancer patients were used to support the clinical relevance of our observations.

Results: We demonstrate that SnMP inhibits immune suppression of chemotherapy-elicited CD8+ T cells by targeting myeloid HO-1 activity in the tumor microenvironment. Microarray and survival data from breast cancer patients reveal that HO-1 is a poor prognostic factor in patients receiving chemotherapy. Single-cell RNA-sequencing analysis suggests that the myeloid lineage is a significant source of HO-1 expression, and is co-expressed with the immune checkpoints PD-L1/2 in human breast tumors. In vivo, we therapeutically compare the efficacy of targeting these two pathways alongside immune-stimulating chemotherapy, and demonstrate that the efficacy of SnMP compares favorably with PD-1 blockade in preclinical models.

Conclusions: SnMP could represent a novel immune checkpoint therapy, which may improve the immunological response to chemotherapy. Clin Cancer Res; 24(7); 1617–28. ©2018 AACR.
Sensation of Cold during the Ice Water Test Corresponds to the Perception of Pain during Botulinum Toxin Bladder Wall Injections
Authors: Reitz André , Hüsch Tanja , Doggweiler Regula , Buse Stephan , Haferkamp Axel
Published: January 2018

Aims: To investigate the association of bladder cold sensation (BCS) during the ice water test (IWT) and pain perception when botulinum toxin injections (BTI) are administered into the bladder wall. Material and Methods: In 86 patients with idiopathic overactive bladder, the BCS during the IWT was investigated. Patients were divided into 2 groups: with and without BCS. During subsequent administration of BTI, the number of perceived and painful injections as well as the pain levels on a 0-100 pain scale were compared in both groups using Student t test. Results: Thirty-five patients reported a BCS, while 51 did not. After 10 BTI, the mean number of perceived injections was 7.9 in patients with and 2.4 in patients without BCS (p < 0.0001). The mean number of painful injections was 5.4 in patients with BCS and 4.3 in patients without (p < 0.001). Mean levels on a 0-100 pain scale were 33.7 in patients with and 17.8 in patients without cold sensation (p < 0.0001). Conclusion: The association of BCS during the IWT and pain to during BTI may implicate that the perceptions of cold and pain in the urinary bladder may use similar receptors and neuronal pathways.
Coexisting Granular Cell Tumor and Tubular Adenoma of the Ileocecal Valve
Authors: Gapp Jonathan , Gross John , Chintalacheruvu Lakshmi , Reddymasu Savio
Published: January 2018

Granular cell tumors (GCTs) have been described as neoplasms of Schwann cell origin. They are often benign and notably uncommon in the gastrointestinal tract. Recently, their incidence has become more common, likely as a result of increased colonoscopy screenings. Very few data exist regarding their potential for malignancy, but malignant GCTs have been reported. Here, we report the case of a young female patient who was diagnosed with an atypical GCT on the ileocecal valve with an overlying tubular adenoma which was found incidentally on colonoscopy. This represents the first known report of a GCT with atypical features on the ileocecal valve, as well as a rare case of overlying adenomatous changes. Due to the paucity of cases, there is no clear modus operandi for their management. Furthermore, it is not clear whether surgical or endoscopic interventions or simple observation may be most appropriate. Further studies are needed to evaluate the potential for malignancy of this tumor, as well as its management.
De Novo Bladder Urothelial Neoplasm in Renal Transplant Recipients: A Retrospective, Multicentered Study
Authors: Palazzetti Anna , Bosio Andrea , Dalmasso Ettore , Destefanis Paolo , Fop Fabrizio , Pisano Francesca , Segoloni Giuseppe , Biancone Luigi , Volpe Alessandro , Di Domenico Antonia , Terrone Carlo , Iesari Samuele , Famulari Antonio , Todeschini Paola , Frea Bruno , Gontero Paolo
Published: January 2018

Background and Objectives: Renal transplant recipients (RTRs) have a 2- to 7-fold risk of developing a neoplasm compared to general population. Bladder urothelial neoplasms in this cohort has an incidence of 0.4–2%. Many reports describe a more aggressive behavior. The objective of this study is to describe oncologic characteristics of bladder urothelial neoplasms in RTRs and to evaluate its recurrence, progression, and survival rates. Methods: A retrospective multicentered study was performed evaluating all de novo bladder urothelial neoplasms cases in RTRs from 1988 to 2014. Descriptive statistical analysis and evaluation of recurrence, progression, and survival rates were performed. Results: A total of 28 de novo bladder transitional cell carcinomas (TCCs) were identified (incidence rate 0.64%). Cancer-specific survival rates were 100, 75, and 70% after 1, 5, and 10 years, respectively. Age at diagnosis superior to 60 years was found to be a statistically significant variable for recurrence risk. Progression rate was 14%. Presence of CIS was significantly associated with progression. All cancer-specific deaths were in the high-risk group and all were progressions from non-muscle invasive to muscle invasive bladder cancer. Conclusions: Bladder urothelial neoplasms following renal transplant is associated with a trend toward worst prognosis. Early aggressive treatments, such as early radical cystectomy, might be advisable to reduce cancer-specific deaths.
Sodium Trimetaphosphate as a Novel Strategy for Matrix Metalloproteinase Inhibition and Dentin Remineralization
Authors: Gonçalves Rafael Simões , Scaffa Polliana Mendes Candia , Giacomini Marina Ciccone , Vidal Cristina de Mattos Pimenta , Honório Heitor Marques , Wang Linda
Published: January 2018

The effect of sodium trimetaphosphate (STMP) as an antiproteolytic and remineralizing agent on demineralized dentin was evaluated in vitro. The inhibitory potential of STMP at 0.5, 1.5, 3.5, and 5% against recombinant matrix metalloproteinases (MMPs) MMPs-2 and -9 was assessed by zymography. To investigate its remineralization potential, 40 bovine root specimens were obtained and subjected to a demineralization protocol to produce caries-like dentin lesions. After that, dentin surfaces were divided into 3 areas: (1) mineralized (no treatment); (2) demineralized; and (3) demineralized/treated with STMP and submitted to a pH-cycling associated or not with STMP (1.5, 3.5, or 5% STMP, 10 min of treatment). After that, superficial hardness (SH) and cross-sectional hardness (CSH) were determined. Polarized light microscopy (PLM) was used to qualitatively evaluate mineralization within the caries-like lesions. The zymographic analysis showed that STMP solution is a potent inhibitor of the gelatinolytic activity of MMPs-2 and -9 depending on the dose, since the lowest concentration (0.5%) partially inhibited the enzyme activity, while the higher concentrations completely inhibited enzyme activity. Regarding remineralization effect, only 1.5% STMP solution enhanced both the SH and CSH. PLM showed that the area treated with 1.5% STMP presented similar birefringence as mineralized sound dentin. In conclusion, 1.5% STMP solution is effective as an antiproteolytic agent against MMPs and promotes dentin remineralization.
Portal Vein Embolization versus Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy
Authors: Hashimoto Takuya , Makuuchi Masatoshi
Published: January 2018

Background/Aims: Liver failure after extended hepatic resection is an obstacle that must be overcome by hepatobiliary surgeons. Portal vein embolization (PVE) played an important role in dealing with this issue since the last 30 years. Recently, a new strategy known as “Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)” has been developed. To clarify the advantage and disadvantage of ALPPS, we reviewed the published articles. Methods: A web search was performed in “PubMED” databases to identify the articles published that were related to this topic. Based on the results, a comparative investigation was carried out. Results: The reported advantages of ALPPS are: rapid liver hypertrophy and a remarkably high resectability rate. The hypertrophy rate in PVE and ALPPS is 10–80 and 47–160%. The disadvantages of ALPPS compared to PVE are high morbidity and mortality rates. The morbidity rates for PVE and ALLPS are 8–49 and 12–100%, respectively, and the mortality rates for PVE and ALPPS are 0–8.8 and 0–28.7%, respectively. Due to the short history of ALPPS, details of the mechanism underlying ALPPS have not yet been fully clarified and a suitable indication for the practice of ALPPS is currently under debate. Conclusion: It is imperative that the issue of a high mortality rate following ALPPS is immediately resolved before ALPPS can be widely accepted. In addition, comparison studies between PVE and ALPPS must be conducted to elicit proper and appropriate applications of PVE and ALPPS.
Metastatic Small Cell Carcinoma of the Breast from Cancer of the Uterine Cervix: A Case Report
Authors: Kwak Beom Seok
Published: January 2018

We report here on a case of 51-year-old woman with metastatic small cell carcinoma of the breast that came from her cancer of the uterine cervix. She underwent radical hysterectomy with bilateral salpingo-oophorectomy due to small cell carcinoma of the uterine cervix, and adjuvant radiotherapy was administered to the pelvis. Breast metastasis with a palpable mass then occurred 3 months after the primary surgery. Simple mastectomy and adjuvant chemotherapy were performed. She initially showed a good response to the therapy, yet she ultimately died of multiple metastases with a fulminating disease course. This is an extremely rare case, and only 1 similar case has been reported earlier, so we report on this case along with a review of the relevant literature.
Гастроінтестинальні кровотечі після хірургічного лікування пацієнтів з хронічним панкреатитом
Authors: Shuleika A. Ch. , Vizhinis Y. I. , Arlouski Y. N. , Makki M. Y.
Published: January 2018

Мета роботи: вивчити частоту і раціональні способи лікування післяопераційних шлунково-кишкових кровотеч після резекційних операцій на підшлунковій залозі з приводу хронічного панкреатиту.Матеріали і методи. У дослідження включено 437 пацієнтів, оперованих із приводу хронічного панкреатиту, в тому числі виконано 331 резекційна операція. Післяопераційні шлунково-кишкові кровотечі виникли в 17 (5,1 %) пацієнтів.Результати досліджень та їх обговорення. Консервативну терапію застосовано у 6 пацієнтів. Релапаротомію виконано 7 пацієнтам. Ендоваскулярний гемостаз успішно застосовано у 2 пацієнтів. Виконано ендоскопічний гемостаз зони панкреатоеюноанастомозу з використанням двобалонного ентероскопа. Помер один (5,9 %) пацієнт. Резекції підшлункової залози пов’язані з високим ризиком післяопераційних кровотеч. При пізніх профузний кровотечах показана термінова релапаротомія з зупинкою кровотечі. Вимагають подальшого вивчення можливості ендоваскулярного та ендоскопічного гемостазу.
Оцінка віддалених результатів лікування хворих із ускладненим синдром діабетичної стопи та визначення шляхів надання їм медико-соціальної допомоги
Authors: Tribushnyi O. V.
Published: January 2018

Мета роботи: проаналізувати структуру віддалених результатів хворих іза ускладненим СДС з визначенням показника фізичного і психологічного компонентів здоров’я, стану їх протезування та корекції взуття в ортопедичній майстерні.Матеріали і методи. Під наглядом перебували 724 хворі з ускладненим СДС віком від 36 до 87 років. У 71 (9,8 %) пацієнта захворювання було обтяжене сепсисом. Померли 36 хворих із ускладненим СДС без сепсису (летальність 5,5 %) та 42 – з сепсисом (летальність 59,1 %). На амбулаторне лікування виписали 617 хворих з ускладненим СДС та 29 пацієнтів, які перенесли сепсис. Терміни проведення контрольного огляду були 6 місяців, 1, 2, 3 та 5 років.Результати досліджень та їх обговорення. Показник фізичного та психологічного компонентів здоров’я через півроку не перевищував (43,2±4,7) ум. од. у хворих, котрим виконані “малі” ампутації та (31,3±3,6) ум. од. (Р < 0,05) у пацієнтів після “високих” ампутацій. Через 2 роки покращення в цьому напрямку не відбувалося. Лише одна пацієнтка протезована, менш ніж 25 % хворих користується ортопедичним взуттям. Серед хворих, які перенесли сепсис та були виписані із стаціонару протягом першого року чи навіть раніше, померли 11 (42,3 %), а впродовж 2 – 3 років 12 (46,2 %) хворих. Через 5 років отримано такі дані: з 364 хворих, яких оперували з приводу гангрени нижньої  кінцівки, вижили 23 (6,3 %), а “високу” ампутацію контрлатеральної кінцівки виконано 48 (13,2 %) пацієнтам. З 253 пацієнтів, в анамнезі яких були “малі” ампутації, протягом 5 років були оперовані на передньому відділі стопи цієї ж кінцівки в 14,2 % випадків (36 хворих), на контрлатеральній кінцівці – (12,2 %) 31 хворий. Всього померли 127 (50,2 %) пацієнтів. Дані інших 17 хворих (6,7 %) з’ясувати не вдалося. Віддалені результати у хворих з ускладненим СДС свідчать про відсутність динамічного спостереження за цими хворими на амбулаторному етапі лікування. Оптимально, щоб питання протезування хворих після “високих” ампутацій та підбір ортопедичного взуття пацієнтам після “малих” було б включено до Національної програми допомоги хворим на цукровий діабет.
Диференційна діагностика та лікування парадуоденального панкреатиту.
Authors: Nychytailo M. Yu. , Bulyk I. I. , Nazarko L. R. , Horbunov A. A. , Kolesnyk A. V.
Published: January 2018

Актуальність проблеми діагностики та хірургічного лікування ускладненого парадуоденального панкреатиту зростає у зв’язку зі схожою клінічною та інструментальною семіотикою із протоковою аденокарциномою підшлункової залози на ранніх стадіях. Незважаючи на наявність сучасних методів обстеження, диференціація парадуоденального панкреатиту із злоякісними захворюваннями періампулярної зони становить труднощі. Сукупність результатів специфічних лабораторних та інструментальних методів обстеження дозволяють встановити точний діагноз лише у 75 % пацієнтів, що вимагає пошуку нових діагностичних алгоритмів. Стандартна доопераційна діагностика повинна включати КТ ОЧП, МРТ ОЧП, МРХПГ, ЕУСГ з біопсією. Ендоскопічна ультрасонографія з біопсією та наступним цитологічним дослідженням, незважаючи на свою діагностичну цінність, не дозволяє виключити злоякісне новоутворення періампулярної зони і тільки заключне патологогістологічне дослідження матеріалу верифікує groove – панкреатит. Арсенал оперативних втручань при парадуоденальному панкреатиті коливається від ПДР до панкреасзберігаючих резекцій ДПК. При виборі тактики хірургічного лікування необхідно ґрунтуватись на патогенезі та морфологічному субстраті захворювання. Європейські панкреатологічні центри надають перевагу проксимальній ізольованій резекції підшлункової залози, яка характеризується кращими, порівняно з ПДР, безпосередніми та віддаленими результатами лікування. У разі підозри на злоякісну пухлину підшлункової залози і / або наявності місцевих ускладнень groove–панкреатиту, оптимальним оперативним втручанням є панкреатодуоденальна резекція, яка остаточно верифікує діагноз, усуне клінічні прояви захворювання, що в подальшому покращить якість життя пацієнта.
A ausência da branquitude exila a negritude
Authors: Alves Bernadeth
Published: January 2018

O artigo procura refletir sobre a invisibilidade do negro na sociedade hegemônica branca, a partir da materialidade textual e cênica do espetáculo Branco: o cheiro do lírio e do formol.
Pensar la traducción como obra de arte
Authors: Parra Aline Celia Tonon
Published: January 2018

El siguiente trabajo ha sido presentado para evaluación final del curso realizado en intercambio en la Universidad de Buenos Aires en mayo de 2016. El curso –que se llamó “Filosofía de la Traducción” y cuyo profesor responsable era Horácio Gonzales– incentivaba la discusión de la posibilidad de pensarse un género artístico a partir de los lenguajes de otros géneros y entender cómo se da el proceso de una nueva época o una forma original de sensibilidad antes desconocida a partir de un descubrimiento artístico. Traducción era pensada allí como una práctica de diversas interpretaciones posibles para el hacer y entender artístico y filosófico. ¿Sería posible pensar el propio acto de traducir como una creación artística? A partir de la lectura de diversos autores que permean el tema de manera más teórica –como Benjamin y Haroldo de Campos– y también de autores que lo abordan desde una concepción más poética del tema –como es el caso de Cesar Aira y Jorge Luis Borges–, este ensayo busca abrir nuevas posibilidades para el entendimiento de la traducción como categoría estética.
A new cryptic, rupicolous species of Hemidactylus Oken, 1817 (Squamata: Gekkonidae) from Meghamalai, Tamil Nadu, India
Authors: CHAITANYA R. , LAJMI APARNA , GIRI VARAD B.
Published: January 2018

A distinct new gecko of the genus Hemidactylus is described from the Meghamalai massif in Tamil Nadu, India. This large sized (average SVL 88.2±16.0 to at least 112.2 mm), cryptic, rock-dwelling species is superficially similar to its tuberculate South Asian congeners of comparable size, but can be distinguished from them in having 17–19 longitudinal rows of fairly regularly arranged, strongly keeled, striated tubercles with the two most medial parasagittal rows smaller, flatter, strongly keeled and rounded, increasing in size laterally and becoming strongly conical at the flanks; 8–10 and 10–12 sub-digital lamellae under the first and fourth digits respectively of both manus and pes; 17–22 femoral pores on each side separated medially by a diastema of 10–11 poreless scales; 11–15 supralabials and 9–14 infralabials. Molecular data supports the distinctiveness of this species and helps ascertain its phylogenetic position within the larger Indian Hemidactylus clade.
Probability Distribution for the Visually Observed Fractional Cloud Cover over the Ocean
Authors: Aleksandrova Marina , Gulev Sergey K. , Belyaev Konstantin
Published: January 2018

The authors suggest a three-parameter bounded distribution from the family of mixed gamma distributions for characterizing the probability density distributions of fractional total and low cloud cover over the global oceans. The authors derive both the continuous form of this distribution and its discrete counterpart, which can be directly applied to cloud cover reports. The distribution is applied to the cloud cover characteristics reported by voluntary observing ships (VOS) for the period from 1950 to 2011 after filtering nighttime observations with poor lunar illumination. The suggested distribution demonstrates a high goodness of fit to the data and good skill in capturing probability distributions with different shapes. The authors present seasonal climatologies of the parameters of the derived distribution for the chosen 60-yr period and demonstrate that applying the PDF-based concept to the analysis of cloud cover allows identification of areas where similar mean cloud amounts can be produced by probability distributions with very different shapes. The roles of the different parameters of the distribution in producing the observed cloud conditions in different regions of the World Ocean are discussed. The application of the derived probability distribution allows for accurate estimation of the percentiles of the distribution, which represent the probabilities of specific cloud conditions. These probabilities are presented for both total and low cloud cover, as well as for daytime and nighttime. The authors also discuss the applicability of the suggested distribution for the validation of different cloud cover data products over the globe and the prospects of additional applications.
Temporalis Fascia Transplantation for Sulcus Vocalis and Vocal Fold Scar: Long-Term Outcomes
Authors: Karle William E. , Helman Samuel N. , Cooper Amy , Zhang Yuan , Pitman Michael J.
Published: January 2018

Objective:

Sulcus vocalis and vocal fold scar involve derangement of the superficial lamina propria of the vocal fold, which results in significant dysphonia. Many options exist for treatment, most of which have unsatisfactory and unpredictable outcomes. Autologous transplantation of temporalis fascia into the vocal fold (ATFV) has the potential to be a better treatment option, but long-term outcomes have not been well studied.

Methods:

Retrospective chart review and patient survey. Twenty-one patients diagnosed with vocal fold scar or sulcus vocalis and treated with ATFV with at least 1-year follow-up were included. Voice Handicap Index 10 (VHI-10) questionnaires were collected preoperatively and 6 months postoperatively. Patients were reached at the time of the study to complete another VHI-10 and a Likert scale survey.

Results:

The mean decrease in VHI-10 scores between preoperation and 6 months postoperation was 8.35 ( P < .001). From preoperation to the time of the study (average 44 months; range, 12-72 months), the VHI decreased 13.53 ( P < .001). Eighty-eight percent of patients reported they would recommend this surgery to others with the same diagnosis. Only 1 minor self-limited complication occurred.

Conclusion:

Autologous transplantation of temporalis fascia into the vocal fold for the treatment of vocal fold scar and sulcus vocalis is a safe surgery with good long-term outcomes and high patient satisfaction.
Carbon fiber composites with battery function: Stresses and dimensional changes due to Li-ion diffusion
Authors: Xu Johanna , Lindbergh Göran , Varna Janis
Published: January 2018

Structural composite materials that simultaneously carry mechanical loads, while storing electrical energy offers the potential of significantly reduced total component weight owing to the multifunctionality. In the suggested micro-battery, the carbon fiber is employed as a negative electrode of the battery and also as a composite reinforcement material. It is coated with a solid polymer electrolyte working as an ion conductor and separator while transferring mechanical loads. The coated fiber is surrounded by a conductive positive electrode material matrix. This paper demonstrates a computational methodology for addressing mechanical stresses arising in a conceptualized micro-battery and dimensional changes of the cell during electrochemical cycling, caused by time-dependent gradients in lithium ion concentration distribution.
Mitral valve replacement via a left thoracotomy in dextrocardia and situs solitus
Authors: García Vieites María , Martinez-Sapiña Llanas María Jose , Gómez Zincke Marcos , Bouzas Zubeldía Beatriz , Bautista-Hernandez Victor
Published: January 2018

Dextrocardia with situs solitus and severe mitral regurgitation is a rare clinical presentation which posse a surgical challenge and requires specific preoperative planning. A 54-year-old women with this anatomy, multiple thoracic procedures, and severe mitral valve regurgitation underwent successful mitral valve replacement with a 27-mm mechanical prosthesis through a left thoracotomy under ventricular fibrillation, on the basis of computed tomography findings. We emphasize the importance of preoperative planning and a surgical approach through a left thoracotomy and under ventricular fibrillation.
Penetrating injury of the ascending aorta complicating a sternal biopsy
Authors: Lahdhili Hatem , Lajmi Mokhles , Bey Moncef , Hachicha Saber , Taamallah Karima , Chenik Slim
Published: January 2018

Bone marrow aspiration and trephine biopsy are considered safe procedures. Some serious but rare adverse events directly attributable to these procedures have been related in a few reports in the literature. We report a rare case of ascending aortic injury following a sternal trephine biopsy.
Knowledge Performance as an Arbitrator between the Relationship of Organizational Commitment and Productivity
Authors: Saini Damini
Published: January 2018

In this article, an attempt is made to explore if the knowledge performance (KP) mediates the commitment of the employees and perceived productivity of the firm in the Indian context. This research study employed a quantitative method using a cross-sectional survey design to seek the correlation among the organizational commitment (OC), KP and productivity of the employees. A non-probability convenience sample was obtained from this population group and was based on accessibility. The following research study examined whether KP mediates the relationship between OC and productivity. Generalization of this study’s results to circumstances in other countries may not be possible because the target population was employees in Indian corporations. The study can be helpful in addressing the gap of empirical analysis in relation with KP and job-related outputs in managerial context in the Indian service sector corporations.
Effects and underlying mechanisms of unstable shoes on chronic low back pain: a randomized controlled trial
Authors: Lisón Juan Francisco , Ortega-Santana Borja , Antón-Nogués Álvaro , González-Requena Palmy , Vera-Hervás Cristina , Doménech-Fernández Julio , Sánchez-Zuriaga Daniel , Salvador-Coloma Pablo
Published: January 2018

Objective:

To investigate the effects that wearing unstable shoes has on disability, trunk muscle activity, and lumbar spine range of motion (ROM) in patients with chronic lower back pain (CLBP).

Design:

Randomized controlled trial.

Setting:

Orthopedic Surgery Service.

Participants:

We randomized 40 adults with nonspecific CLBP either to an unstable shoes group ( n = 20) or to the control group ( n = 20).

Intervention:

The participants in the unstable shoes group were advised to wear these shoes for a minimum of six hours a day for four weeks. Control group participants were asked to continue wearing their regular shoes.

Outcome measures:

Our primary outcome was measurement of back-related dysfunction, assessed using the Roland-Morris Disability Questionnaire. Secondary outcomes included changes in electromyographic (EMG) activity of erector spinae (ES), rectus abdominis (RA), internus obliquus (IO), and externus obliquus (EO) muscles, and changes in lumbar spine ROM.

Results:

Between-group analysis highlighted a significant decrease in disability in the unstable shoes group compared to the control (−5, 95% confidence interval (CI) = −8.4 to −1.6). Our results revealed a significant increase in the percentage of RA, ES, IO, and EO EMG activity and in lumbar spine ROM in the unstable shoes group compared to the control group. Moreover, our results showed a significant negative correlation between disability and the percentage of ES, RA, and IO muscle activity at the end of the intervention.

Conclusion:

This study shows that the use of unstable shoes contributes to improvements in disability, which are likely related to increased trunk muscle activity and lumbar spine ROM.
Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET
Authors: Andersen Julie B , Lindberg Ulrich , Olesen Oline V , Benoit Didier , Ladefoged Claes N , Larsson Henrik BW , Højgaard Liselotte , Greisen Gorm , Law Ian
Published: January 2018

In this study, a new hybrid PET/MRI method for quantitative regional cerebral blood flow (rCBF) measurements in healthy newborn infants was assessed and the low values of rCBF in white matter previously obtained by arterial spin labeling (ASL) were tested. Four healthy full-term newborn subjects were scanned in a PET/MRI scanner during natural sleep after median intravenous injection of 14 MBq 15O-water. Regional CBF was quantified using a one-tissue-compartment model employing an image-derived input function (IDIF) from the left ventricle. PET rCBF showed the highest values in the thalami, mesencephalon and brain stem and the lowest in cortex and unmyelinated white matter. The average global CBF was 17.8 ml/100 g/min. The average frontal and occipital unmyelinated white matter CBF was 10.3 ml/100 g/min and average thalamic CBF 31.3 ml/100 g/min. The average white matter/thalamic ratio CBF was 0.36, significantly higher than previous ASL data. The rCBF ASL measurements were all unsuccessful primarily owing to subject movement. In this study, we demonstrated for the first time, a minimally invasive PET/MRI method using low activity 15O-water PET for quantitative rCBF assessment in unsedated healthy newborn infants and found a white/grey matter CBF ratio similar to that of the adult human brain.
The resting-state fMRI arterial signal predicts differential blood transit time through the brain
Authors: Tong Yunjie , Yao Jinxia (Fiona) , Chen J Jean , Frederick Blaise deB
Published: January 2018

Previous studies have found that aperiodic, systemic low-frequency oscillations (sLFOs) are present in blood-oxygen-level-dependent (BOLD) data. These signals are in the same low frequency band as the “resting state” signal; however, they are distinct signals which represent non-neuronal, physiological oscillations. The same sLFOs are found in the periphery (i.e. finger tips) as changes in oxy/deoxy-hemoglobin concentration using concurrent near-infrared spectroscopy. Together, this evidence points toward an extra-cerebral origin of these sLFOs. If this is the case, it is expected that these sLFO signals would be found in the carotid arteries with time delays that precede the signals found in the brain. To test this hypothesis, we employed the publicly available MyConnectome dataset (a two-year longitudinal study of a single subject) to extract the sLFOs in the internal carotid arteries (ICAs) with the help of the T1/T2-weighted images. Significant, but negative, correlations were found between the LFO BOLD signals from the ICAs and (1) the global signal (GS), (2) the superior sagittal sinus, and (3) the jugulars. We found the consistent time delays between the sLFO signals from ICAs, GS and veins which coincide with the blood transit time through the cerebral vascular tree.
Teaching Design Thinking in Marketing: Linking Product Design and Marketing Strategy in a Product Development Class
Authors: Chen Steven , Benedicktus Ray , Kim Yuna , Shih Eric
Published: January 2018

Design thinking refers to the implementation of a firm’s design philosophy into design processes and outputs. This article introduces two design thinking approaches—user-centered design and design-driven innovation—that frame product design activities and show how these approaches can be incorporated into marketing curricula. The aim of this article is to show how marketing educators can help students appreciate and understand the processes and consequences of developing new products using different design thinking approaches. First, an experiment is conducted to examine the effect of design thinking approaches (user-centered design, design-driven innovation) on design and marketing outcomes (perceived originality, perceived usefulness, and perceived value). Second, based on the results of the study, the article develops a step-by-step guide on how to execute a design thinking module in a product-oriented marketing course.
Transjugular intrahepatic portosystemic stent shunt placement and embolization for hemorrhage associated with rupture of anorectal varices
Authors: Wu Xiuyan , Xuan Wei , Song Lei
Published: January 2018

Portal hypertension can lead to ectopic varices, which occur most frequently in the rectum. Rectal variceal bleeding in patients with portal hypertension is rare but can be life-threatening if not diagnosed and treated in a timely manner. However, no specific treatment guidelines have been established for rectal variceal bleeding. We herein report a case involving a woman with portal hypertension due to autoimmune liver disease who was successfully treated with a transjugular intrahepatic portosystemic stent shunt and variceal embolization. We recommend treatment of refractory ectopic variceal bleeding with a transjugular intrahepatic portosystemic stent shunt in combination with embolization.