bluuebunny/crossref_metadata_2025 huggingface dataset:
Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?
Authors: Davis C. R. , Karl J. , Granell R. , Kirwan J. R. , Fasham J. , Johansen J. , Garnero P. , Sharif M.
Published: November 2007

Objective

Osteoarthritis (OA) is a complex heterogeneous joint disease affecting more than 35 million people worldwide. The current gold standard diagnostic investigation is the plain radiograph, which lacks sensitivity. Biochemical markers have the potential to act as adjunct markers for imaging in the assessment of knee OA. We undertook this study to determine the association between individual biochemical markers and radiographic features, and to establish whether the association is strengthened when selected biochemical markers are combined into a single factor (a theoretical marker).

Methods

Twenty serum and urinary biochemical markers were analyzed in 119 patients with predominantly tibiofemoral knee OA. Pearson's correlation was performed, and corresponding coefficients of determination (R2) were calculated to determine the association between biochemical markers and a range of imaging features from radiographs and dual x‐ray absorptiometry of the knee. Biochemical markers demonstrating a significant association (P < 0.05) with a specific imaging feature were combined by principal components analysis (PCA). Pearson's correlation was repeated to establish whether the combined panel of biochemical markers showed a stronger association with imaging than the best single marker.

Results

Fourteen biochemical markers showed significant associations with one or more imaging features. By combining specific panels of biochemical markers to form factors, the association of markers with imaging features (R2) increased from 11.9% to 22.7% for the Kellgren/Lawrence (K/L) score, from 5.9% to 9.2% for joint space width (JSW), from 6.6% to 10.8% for sclerosis, from 13.5% to 22.6% for osteophytes, and from 12.0% to 14.2% for bone mineral density (BMD). Biochemical markers identifying patients with osteophytes overlapped with those correlated with a high K/L score, while markers of subchondral BMD formed a completely separate group. Biochemical markers of JSW included markers associated with both osteophytes and BMD.

Conclusion

The PCA results suggest that biochemical marker combinations may be more sensitive than individual biochemical markers for reflecting structural damage in patients with knee OA. The differences in biochemical marker profiles associated with osteophytes compared with those associated with subchondral BMD raise the possibility that these 2 processes, commonly seen in bone in knee OA, have underlying biologic differences.
Functional magnetic resonance imaging assessment of cognitive function in childhood‐onset systemic lupus erythematosus: A pilot study
Authors: DiFrancesco Mark W. , Holland Scott K. , Ris M. Douglas , Adler Caleb M. , Nelson Shannen , DelBello Melissa P. , Altaye Mekibib , Brunner Hermine I.
Published: November 2007

Objective

To investigate changes in brain activation patterns detected by functional magnetic resonance imaging (FMRI), and the relationship between FMRI activation patterns and results of formal neuropsychological testing, in patients with childhood‐onset systemic lupus erythematosus (SLE).

Methods

Ten patients with childhood‐onset SLE underwent formal neuropsychological testing and FMRI using 3 paradigms: a continuous performance task (CPT) to evaluate attention, an N‐Back task to assess working memory, and verb generation to evaluate language processing. Composite Z maps were generated to summarize the brain activation patterns for each FMRI paradigm in patients with childhood‐onset SLE and to compare these patterns with those observed in healthy controls. Between‐group comparison Z maps showing differences in activation between childhood‐onset SLE patients and controls were generated, using a significance level of P < 0.05 in a general linear model.

Results

Compared with the control group, the childhood‐onset SLE group showed statistically significant increased activation of brain areas involved in the CPT, N‐Back, and verb generation tasks. In contrast, in the absence of active stimulus, e.g., during times of the paradigm control tasks, childhood‐onset SLE patients consistently undersuppressed activity in the expected brain areas. Activation in selected cortical areas was found to correlate negatively with results of a subset of individual neuropsychological test scores.

Conclusion

FMRI abnormalities are present in childhood‐onset SLE, manifesting as an imbalance between active and inhibitory responses to an array of stimuli. Differences in brain activation patterns compared with those observed in controls suggest that childhood‐onset SLE may be associated with abnormalities in white matter connectivity resulting in neuronal network dysfunction, rather than injury of specific gray matter areas.
Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor–associated periodic syndrome
Authors: Todd Ian , Radford Paul M. , Ziegler‐Heitbrock Loems , Ghaemmaghami Amir M. , Powell Richard J. , Tighe Patrick J.
Published: November 2007

Objective

Tumor necrosis factor receptor–associated periodic syndrome (TRAPS) is an inherited autosomal‐dominant autoinflammatory condition caused by mutations in the ectodomain of the 55‐kd tumor necrosis factor (TNF) receptor superfamily 1A. Proinflammatory blood monocytes with the phenotype CD14+,CD16+,HLA–DR++ are a major source of TNF, and the number of such monocytes is increased during infection and inflammation. The aim of this study was to investigate whether the expression of circulating CD16+ monocytes is affected in patients with TRAPS.

Methods

Peripheral blood obtained from patients with TRAPS and healthy control subjects was stained with monoclonal antibodies to detect CD14++,CD16− monocytes and CD14+,CD16+ monocytes, using flow cytometry. Lipopolysaccharide‐induced TNF production was measured by intracellular cytokine staining. Activation‐induced shedding of CD16 was investigated by treating blood samples with phorbol myristate acetate.

Results

The level of CD16 expression by CD14+,CD16+ monocytes, but not their absolute number, was significantly elevated in patients with TRAPS, even though the patients were not experiencing clinically overt episodes of autoinflammation at the time of sampling. These findings are similar to those for the C‐reactive protein levels and erythrocyte sedimentation rates in the same patients. The enhanced level of CD16 expression by monocytes from patients with TRAPS was not attributable to a defect in activation‐induced shedding of CD16. The CD14+,CD16+ monocytes were the predominant source of TNF in both patients and healthy control subjects.

Conclusion

The level of CD16 expression by monocytes was elevated in patients with TRAPS, as a feature of the underlying constitutive inflammation status.
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts
Authors: Shi‐wen Xu , Kennedy Laura , Renzoni Elisabetta A. , Bou‐Gharios George , du Bois Roland M. , Black Carol M. , Denton Christopher P. , Abraham David J. , Leask Andrew
Published: November 2007

Objective

Fibrosis is excessive scarring caused by the accumulation and contraction of extracellular matrix proteins and is a common end pathway in many chronic diseases, including scleroderma (systemic sclerosis [SSc]). Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming growth factor β (TGFβ) induces endothelin 1 (ET‐1) in human lung fibroblasts by a Smad‐independent, JNK‐dependent mechanism. The goal of this study was to assess whether ET‐1 is a downstream mediator of the profibrotic effects of TGFβ in lung fibroblasts.

Methods

We used a specific endothelin receptor antagonist to determine whether ET‐1 is a downstream mediator of TGFβ responses in lung fibroblasts, using microarray technology, real‐time polymerase chain reaction, and Western blot analyses.

Results

The ability of TGFβ to induce the expression of a cohort of profibrotic genes, including type I collagen, fibronectin, and CCN2, and to contract a collagen gel matrix, depends on ET‐1.

Conclusion

ET‐1 contributes to the ability of TGFβ to promote a profibrotic phenotype in human lung fibroblasts, consistent with the notion that endothelin receptor antagonism may be beneficial in controlling fibrogenic responses in lung fibroblasts.
Ferutinin stability in human plasma and interaction with human serum albumin
Authors: Greige‐Gerges H. , Diab Y. , Farah J. , Magdalou J. , Haddad C. , Ouaini N.
Published: November 2007

Ferutinin is a potent phytoestrogen extracted from plants of the genus Ferula. The biological activity of this sesquiterpene is associated with the esterification of p‐hydroxybenzoic acid with the daucane alcohol, jaeschkeanadiol. A HPLC method was developed to investigate the stability of ferutinin in acidic and basic solutions (pH 1.5 and 9.0, respectively), in buffer (pH 7.4) as well as in serial dilutions of albumin and in human plasma. The degradation of ferutinin was relatively slow at physiological pH 7.4 compared with low or high pH. Ferutinin was fully stable in human plasma as well as in albumin solution and the stability increased with albumin concentration. The binding of ferutinin to albumin was investigated by fluorescence spectroscopy. Ferutinin decreased the fluorescence of HSA and that of the only tryptophan residue located in domain IIA. As a result of the interaction between ferutinin and albumin, the binding of bilirubin decreased. The stability of ferutinin in plasma is attributable to ferutinin–albumin binding. Copyright © 2007 John Wiley & Sons, Ltd.
Children for sale: Child trafficking in Southeast Asia
Authors: Rafferty Yvonne
Published: November 2007

The paper provides an overview of child trafficking in Southeast Asia. It highlights human rights and international laws relevant to this egregious form of child abuse. It describes the experiences of the young victims and the consequences for their physical and emotional well‐being. It reviews the risk factors at the level of the community setting (poverty and economic inequality), the child and his/her family (gender, age, race/ethnicity, family functioning, education) and broader contextual variables at the macro level (gender inequality and discrimination, demand factors). Finally, it presents recommendations for legal and policy initiatives to cease the sale and exploitation of children. Copyright © 2007 John Wiley & Sons, Ltd.
Ternary Rare Earth and Actinoid Transition Metal Carbides Viewed as Carbometalates.
Authors: Dashjav Enkhtsetseg , Kreiner Guido , Schnelle Walter , Wagner Frank R. , Kniep Ruediger , Jeitschko Wolfgang
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Pr2Se3—PrSe2 System: Studies of the Phase Relationships and the Modulated Crystal Structure of PrSe1.85.
Authors: Doert Thomas , Graf Christian , Schmidt Peer , Vasilieva Inga G. , Simon Paul , Carrillo‐Cabrera Wilder
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Change of Layered Perovskite La2Ti2O7 at High Pressures.
Authors: Zhang F. X. , Lian J. , Becker U. , Ewing R. C. , Wang L. M. , Hu Jingzhu , Saxena S. K.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure and Magnetism of Rare‐Earth‐Substituted Ca3Co2O6.
Authors: Hervoches Charles H. , Fjellvaag Helmer , Kjekshus Arne , Fredenborg Vivian Miksch , Hauback Bjoern C.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Study of VOx Doped Aluminium Fluoride and Aluminium Oxide Catalysts.
Authors: Scheurell Kerstin , Scholz Gudrun , Kemnitz Erhard
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Construction of a Double‐Layered Tetrahedral Network within a Perovskite Host: Two‐Step Route to the Alkali‐Metal‐Halide Layered Perovskite, (LixCl)LaNb2O7.
Authors: Viciu Liliana , Kodenkandath Thomas A. , Wiley John B.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bi2n+4MonO6(n+1) with n = 3, 4, 5, 6: A New Series of Low‐Temperature Stable Phases in the mBi2O3—MoO3 System (1.0 < m < 1.7): Structural Relationships and Conductor Properties.
Authors: Vila Eladio , Landa‐Canovas Angel R. , Galy Jean , Iglesias Juan E. , Castro Alicia
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New C2‐Symmetric Diphosphite Ligands Derived from Carbohydrates: Effect of the Remote Stereocenters on Asymmetric Catalysis.
Authors: Axet M. Rosa , Benet‐Buchholz Jordi , Claver Carmen , Castillon Sergio
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Atom‐Transfer Radical Addition (ATRA) and Cyclization (ATRC) Reactions Catalyzed by a Mixture of [RuCl2Cp*(PPh3)] and Magnesium.
Authors: Thommes Katrin , Icli Burcak , Scopelliti Rosario , Severin Kay
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Creating Quaternary Centers with High Exo Stereoselectivity Using Activated α‐Alkynyl Dienophiles.
Authors: Min Sun‐Joon , Jones Gavin O. , Houk K. N. , Danishefsky Samuel J.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Substituted Benzocarbocycles by Palladium‐Catalyzed Cascade Reactions Featuring a C(sp3)—H Activation Step.
Authors: Hitce Julien , Baudoin Olivier
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Step RhCl3‐Catalyzed Deprotection of Acyclic N‐Allyl Amides.
Authors: Zacuto Michael J. , Xu Feng
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Inclusion Compounds of L,D‐Dipeptide with Small Sulfoxides: Flexible Sheet Structure of (S)‐Phenylglycyl‐(R)‐phenylglycine.
Authors: Akazome Motohiro , Hirabayashi Atsushi , Senda Kyoko , Ogura Katsuyuki
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selectively Formylated and Bridged Calix[6]arene Derivatives at the Upper Rim.
Authors: Liu Jun‐Min , Zheng Qi‐Yu , Chen Chuan‐Feng , Huang Zhi‐Tang
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Short and Practical Synthesis of N′,N′‐Disubstituted N‐Aryl‐1,2‐ethylenediamines by a Decarboxylative Ring‐Opening Reaction under Nucleophilic Conditions.
Authors: Morita Yasuhiro , Ishigaki Takeshi , Kawamura Kuniaki , Iseki Katsuhiko
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxidation of Unsaturated Primary Alcohols and ω‐Haloalkanols with 4‐Acetylamino‐2,2,6,6‐tetramethylpiperidine‐1‐oxoammonium Tetrafluoroborate
Authors: Zakrzewski Jerzy , Grodner Jacek , Bobbitt James M. , Karpinska Monika
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Effect of Lithium Chloride on Tuning the Reactivity of Pauson—Khand Reactions Catalyzed by Palladium—Tetramethylthiourea.
Authors: Deng Lu‐Jiang , Liu Jing , Huang Ji‐Qing , Hu Yanhe , Chen Mao , Lan Yu , Chen Jia‐Hua , Lei Aiwen , Yang Zhen
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Photochemical Rearrangements of Norbornadiene Pauson—Khand Cycloadducts.
Authors: Lledo Agusti , Benet‐Buchholz Jordi , Sole Albert , Olivella Santiago , Verdaguer Xavier , Riera Antoni
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective and Asymmetric Diels—Alder Reaction of 1‐ and 2‐Substituted Cyclopentadienes Catalyzed by a Broensted Acid Activated Chiral Oxazaborolidine.
Authors: Payette Joshua N. , Yamamoto Hisashi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Base‐Free Mizoroki—Heck Reaction Catalyzed by Rhodium Complexes.
Authors: Martinez Remi , Voica Florina , Genet Jean‐Pierre , Darses Sylvain
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convenient Synthesis of (1‐Propynyl)arenes Through a One‐Pot Double Elimination Reaction, and Their Conversion to Enynes.
Authors: An De‐Lie , Zhang Zhiyang , Orita Akihiro , Mineyama Hidetaka , Otera Junzo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Sandmeyer Bromination.
Authors: Beletskaya Irina P. , Sigeev Alexander S. , Peregudov Alexander S. , Petrovskii Pavel V.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lewis Acid Promoted Mannich Type Reactions of α,α‐Dichloro Aldimines with Potassium Organotrifluoroborates.
Authors: Stas Sara , Tehrani Kourosch Abbaspour
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chiral Thiourea Catalyzed Direct Mannich Reaction.
Authors: Yamaoka Yousuke , Miyabe Hideto , Yasui Yoshizumi , Takemoto Yoshiji
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Highly Selective Oxybromination of Phenols with Dioxygen.
Authors: Menini Luciano , Parreira Luciana A. , Gusevskaya Elena V.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective Synthesis of 5‐Alkylsalicylates, 5‐Alkyl‐2‐hydroxy‐acetophenones, and 5‐Alkyl‐2‐hydroxy‐benzophenones by [3 + 3] Cyclization of 1,3‐Bis(silyl enol ethers) with 2‐Alkyl‐1,1,3,3‐tetraethoxypropanes.
Authors: Mamat Constantin , Buettner Stefan , Trabhardt Tiana , Fischer Christine , Langer Peter
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Room‐Temperature Copper‐Catalyzed α‐Arylation of Malonates.
Authors: Yip Sau Fan , Cheung Hong Yee , Zhou Zhongyuan , Kwong Fuk Yee
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design of Axially Chiral Dicarboxylic Acid for Asymmetric Mannich Reaction of Arylaldehyde N‐Boc Imines and Diazo Compounds.
Authors: Hashimoto Takuya , Maruoka Keiji
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies on Novel Synthetic Methodologies. Part 149. A Simple and Efficient Synthesis of gem‐Dihydroperoxides from Ketones Using Aqueous Hydrogen Peroxide and Catalytic Ceric Ammonium Nitrate.
Authors: Das Biswanath , Krishnaiah Maddeboina , Veeranjaneyulu Boyapati , Ravikanth Bommena
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metal‐Free Synthesis of Sterically Crowded Biphenyls by Direct Ar—H Substitution in Alkyl Benzenes.
Authors: Dichiarante Valentina , Fagnoni Maurizio , Albini Angelo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design and Synthesis of Thioether‐Imidazolium Chlorides as Efficient Ligands for Palladium‐Catalyzed Suzuki—Miyaura Coupling of Aryl Bromides with Arylboronic Acids.
Authors: Kuriyama Masami , Shimazawa Rumiko , Shirai Ryuichi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
FeCl2‐Catalyzed Selective C—C Bond Formation by Oxidative Activation of a Benzylic C—H Bond.
Authors: Li Zhiping , Cao Lin , Li Chao‐Jun
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium(IV) Alkylidenes as Precatalysts for Direct Arylations of Alkenes with Aryl Chlorides and an Application to Sequential Catalysis.
Authors: Ackermann Lutz , Born Robert , Alvarez‐Bercedo Paula
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solvent‐Free One‐Pot Synthesis of Amidoalkyl Naphthols Catalyzed by Silica Sulfuric Acid.
Authors: Srihari Galla , Nagaraju Manda , Murthy Madugula Marthanda
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Simple and Versatile Synthesis of 1,2‐Diarylacenaphthylenes via Suzuki—Miyaura Coupling, and Its Application in the Synthesis of a New Acenaphthylene‐1,2‐bis(p‐quinone methide) Derivative.
Authors: Kurata Hiroyuki , Takehara Yuko , Kim Sang , Sakai Kanae , Matsumoto Kouzou , Kawase Takehi , Oda Masaji
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Efficient and Site‐Selective [3 + 2] Cycloaddition of Carbene‐Derived Ambident Dipoles with Ketenes for a Straightforward Synthesis of Spiro‐Pyrrolidones.
Authors: Li Jia‐Qi , Liao Rong‐Zhen , Ding Wan‐Jian , Cheng Ying
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fluoride‐Assisted Regioselective Conversion of Functionalized Furans to α‐Substituted γ‐Hydroxybutenolides Using Singlet Oxygen.
Authors: Patil Santoshkumar N. , Liu Fei
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Hexahydrocyclopenta[c]furans by an Intramolecular Iron‐Catalyzed Ring Expansion Reaction.
Authors: Hilt Gerhard , Bolze Patrick , Heitbaum Maja , Hasse Katrin , Harms Klaus , Massa Werner
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyclization of Dialkyl(4‐hydroxy‐2‐butynyl)‐(3‐isopropenylpropargyl)ammonium Salts (I) and Intramolecular Recyclization of the Resultant Products (II).
Authors: Chukhajian E. O. , Nalbandyan M. K. , Panosyan G. A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Synthesis of Acetylene‐Substituted Terthiophenes.
Authors: Wagner Pawel , Partridge Ashton C. , Jolley Kenneth W. , Officer David L.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Simple Approach to the Synthesis of Highly Functionalized 3‐Alkylidene‐2,3‐dihydro‐1H‐pyrrole‐2‐ol Derivatives (IV), (VIII) and Related Pyrroles (VI).
Authors: Nasiri Farough , Pourdavaie Kourosh
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Asymmetric Multicomponent [C+NC+CC] Synthesis of Highly Functionalized Pyrrolidine Derivatives.
Authors: Ibrahem Ismail , Rios Ramon , Vesely Jan , Cordova Armando
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Pyrrolidine‐Substituted Benzamides via Iodocyclization of β‐Enaminoesters.
Authors: De Oliveira Eliseu O. , Brandt Carlos A. , Da Silveira Maria A. B. , Glennon Richard A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heck‐Type Cyclization of Oxime Ethers: Stereoselective Carbon—Carbon Bond Formation with Aryl Halides to Produce Heterocyclic Oximes.
Authors: Ohno Hiroaki , Aso Akimasa , Kadoh Yoichi , Fujii Nobutaka , Tanaka Tetsuaki
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel One‐Step Synthesis of 2‐Carbonyl/Thiocarbonyl Isoindolinones and Mechanistic Disclosure on the Rearrangement Reaction of o‐Phthalaldehyde with Amide/Thioamide Analogues.
Authors: Wan Jieping , Wu Bin , Pan Yuanjiang
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium(II)‐Catalyzed Cyclization of Azabenzonorbornadienes with Alkynes.
Authors: Burton Ryan R. , Tam William
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Base‐ and Ligand‐Free Room‐Temperature Synthesis of N‐Fused Heteroaromatic Compounds via the Transition Metal Catalyzed Cycloisomerization Protocol.
Authors: Seregin Ilya V. , Schammel Alex W. , Gevorgyan Vladimir
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Regiocontrolled Synthesis and Antimicrobial Activity of Pyrazoles.
Authors: Braibante Mara E. F. , Braibante Hugo T. S. , de Carvalho Tavares Luciana , Rohte Simone F. , Costa Carla C. , Morel Ademir F. , Stueker Caroline Z. , Burrow Robert A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Resource‐Efficient and Highly Flexible Procedure for a Three‐Component Synthesis of 2‐Imidazolines.
Authors: Elders Niels , Schmitz Rob F. , de Kanter Frans J. J. , Ruijter Eelco , Groen Marinus B. , Orru Romano V. A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Copper‐Catalyzed N‐Arylation of Imidazoles and Benzimidazoles.
Authors: Altman Ryan A. , Koval Erica D. , Buchwald Stephen L.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Hetero‐Diels—Alder Reaction of 3‐(Trifluoroacetyl)chromones with Cyclic Enol Ethers: Synthesis of 3‐Aroyl‐2‐(trifluoromethyl)pyridines with ω‐Hydroxyalkyl Groups.
Authors: Sosnovskikh Vyacheslav Ya. , Irgashev Roman A. , Khalymbadzha Igor A. , Slepukhin Pavel A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 2,3‐Dihydro‐10bH‐oxazolo[2,3‐a]isoquinolines from ortho‐Lithiated Phenyloxazolinyloxiranes.
Authors: Capriati Vito , Florio Saverio , Luisi Renzo , Perna Filippo Maria
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Synthesis of Pyridine Derivatives.
Authors: Movassaghi Mohammad , Hill Matthew D. , Ahmad Omar K.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Isocyanide‐Based Three‐Component Reaction: Synthesis of Highly Substituted 1,6‐Dihydropyrazine‐2,3‐dicarbonitrile Derivatives.
Authors: Shaabani Ahmad , Maleki Ali , Moghimi‐Rad Jafar
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Homolytic Substitution at Phosphorus for the Synthesis of Alkyl and Aryl Phosphanes.
Authors: Vaillard Santiago E. , Mueck‐Lichtenfeld Christian , Grimme Stefan , Studer Armido
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cycloalumination of α,ω‐Diolefins with EtAlCl2 Catalyzed by Zirconium Complexes.
Authors: Khafizova L. O. , Gilyazev R. R. , Tyumkina T. V. , Ibragimov T. V. , Ibragimov A. G. , Dzhemilev U. M.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient Synthesis of CD Rings Model for Merrilactone A (I).
Authors: Harada Kenichi , Ito Hitoshi , Hioki Hideaki , Fukuyama Yoshiyasu
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Steroid Template Associated Peptides: Design, Synthesis and 2D NMR Characterization of a Novel Protected 18‐Phe,19‐Gly‐Containing Steroidal Compound.
Authors: Bjelakovic Mira S. , Krstic Natalija M. , Juranic Nenad , Dabovic Milan M. , Gojkovic Svetislav V. , Kessler Martin , Kalvoda Jaroslav , Pavlovic Vladimir D.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular 1,5‐ versus 1,6‐Hydrogen Abstraction Reaction Promoted by Alkoxyl Radicals in Pyranose and Furanose Models.
Authors: Francisco Cosme G. , Freire Raimundo , Herrera Antonio J. , Perez‐Martin Ines , Suarez Ernesto
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Arnoamine B (IV) and Related Compounds (V).
Authors: Nakahara Shinsuke , Kubo Akinori , Mikami Yuzuru , Mitani Hiroki
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lipase‐Catalyzed Asymmetric Synthesis of Desprenyl‐carquinostatin A (V) and Descycloavandulyl‐lavanduquinocin.
Authors: Choshi Tominari , Uchida Yoshinari , Kubota Yukiko , Nobuhiro Junko , Takeshita Mitsuhiro , Hatano Takushi , Hibino Satoshi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Murrayanine Involving 4,5‐Dimethyleneoxazolidin‐2‐ones and a Palladium(0)‐Catalyzed Diaryl Insertion.
Authors: Bernal Pablo , Tamariz Joaquin
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Carbonyl and Fluoroalkyl o‐Quinone Methides from β‐Lapachone.
Authors: da Silva Milton N. , Ferreira Sabrina B. , Jorqueira Alessandra , de Souza Maria C. B. V. , Pinto Antonio V. , Kaiser Carlos R. , Ferreira Vitor F.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrophilic and Hydrophobic Nano‐Sized Mn3O4 Particles.
Authors: Gibot Pierre , Laffont Lydia
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Atypical Compounds of Gases, which Have Been Called “Noble”
Authors: Grochala Wojciech
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Template‐Controlled Reactivity in the Organic Solid State by Principles of Coordination‐Driven Self‐Assembly
Authors: Bucar Dejan‐Kresimir , Papaefstathiou Giannis S. , Hamilton Tamara D. , Chu Qianli L. , Georgiev Ivan G. , MacGillivray Leonard R.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Homo‐ and Heterometallic Coordination Polymers from the F Elements
Authors: Cahill Christopher L. , de Lill Daniel T. , Frisch Mark
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Environmentally Benign Organometallic Catalysis for Drug Discovery and Its Application
Authors: Arisawa Mitsuhiro
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Architectural Design, Interior Decoration and Three‐Dimensional Plumbing en Route to Multifunctional Nanoarchitectures
Authors: Long Jeffrey W. , Rolison Debra R.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Free Radical Functionalization of Organic Compounds Catalyzed by N‐Hydroxyphthalimide
Authors: Recupero Francesco , Punta Carlo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Glycol‐Modified Silanes: Novel Possibilities for the Synthesis of Hierarchically Organized (Hybrid) Porous Materials
Authors: Hartmann Sarah , Brandhuber Doris , Huesing Nicola
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Functionalized Sol—Gel Coatings for Optical Applications
Authors: Penard Anne‐Laure , Gacoin Thierry , Boilot Jean‐Pierre
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Histidinoalanine: A Crosslinking Amino Acid
Authors: Taylor Carol M. , Wang Weihua
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of β‐Lactams Using the Kinugasa Reaction
Authors: Pal Runa , Ghosh Subhash Chandra , Chandra Koushik , Basak Amit
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Methods for the Synthesis of Derivatives of 3‐Aminothietane
Authors: Butkevich A. N. , Sokolov V. V. , Tomashevskii A. A. , Potekhin A. A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Zwitterionic Glycosidase Inhibitors: Salacinol and Related Analogues
Authors: Mohan Sankar , Pinto B. Mario
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Syntheses with Aziridinecarboxylate and Aziridinephosphonate Building Blocks
Authors: Zhou Ping , Chen Bang‐Chi , Davis Franklin A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Brown Hydroboration Reaction
Authors: Clay Julia M.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Spin Chemistry of Enzymatic Processes
Authors: Afanasyeva M. S. , Purtov P. A. , Taraban M. B. , Leshina T. V.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Investigating and Exploiting the Electrocatalytic Properties of Hydrogenases
Authors: Vincent Kylie A. , Parkin Alison , Armstrong Fraser A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Heterogeneous Advantage: Biodiesel by Catalytic Reactive Distillation
Authors: Kiss Anton A. , Omota Florin , Dimian Alexandre C. , Rothenberg Gadi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biomass Energy
Authors: Overend Ralph P. , Wright Lynn L.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Induced Chirality in Achiral Media — How Theory Unravels Mysterious Solvent Effects
Authors: Neugebauer Johannes
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Computational Analysis of Natural Molecules and Strategies for the Design of Natural Product‐based Compound Libraries
Authors: Stahura Florence L. , Bajorath Jurgen
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Angiotensin Type 2 Receptor‐Dependent Vasodilation
Authors: Yayama Katsutoshi , Okamoto Hiroshi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Treatment failure after primary and salvage therapy for prostate cancer
Authors: Agarwal Piyush K. , Sadetsky Natalia , Konety Badrinath R. , Resnick Martin I. , Carroll Peter R.
Published: November 2007

BACKGROUND.

The authors report the likelihood of treatment failure and the outcomes after salvage therapy among men with prostate cancer who initially either received external‐beam radiation therapy (EBRT) or underwent radical prostatectomy (RP).

METHODS.

Using a national disease registry, the Cancer of the Prostate Strategic Urological Research Endeavor (CaPSURE) database, 5277 men with prostate cancer were identified who initially either underwent RP (4342 men) or received EBRT (935 men). Outcomes after disease recurrence and subsequent salvage therapy were assessed.

RESULTS.

Recurrent disease developed in 1590 men (30%), including 1003 patients (23%) in the RP group and 587 patients (63%) in the EBRT group, at a mean of 34 months and 38 months, respectively (P = .003). Patients who had recurrent disease had greater rates of overall death (19% vs 3%; P < .01) and bone metastases (15% vs 1%; P < .01). Data after salvage therapy were available for 1050 patients (620 men in the RP group and 430 men in the EBRT group). Androgen‐deprivation therapy (ADT) was the most common salvage treatment in both groups. Overall, 420 men in the RP group (68%) and 319 men in the EBRT group (74%) failed salvage therapy at mean of 43.6 months and 43.8 months, respectively (P = .95). These patients had a greater overall death rate than the 311 patients who did not fail salvage therapy (24.8% vs 6.9%, respectively; P < .001). No survival benefit in terms of prostate cancer‐related death (P = .91) was identified with any particular combination of primary and salvage therapy.

CONCLUSIONS.

Disease recurrence developed in 30% of patients who were treated for prostate cancer, and ADT was the most common salvage therapy used. Patients who failed salvage therapy had worse overall survival, and no survival benefit was noted for any particular combination of primary and salvage therapy. Cancer 2008. © 2007 American Cancer Society.
Hydraulic conductivity estimation in partially saturated soils using a full‐Newton method
Authors: Guarracino L. , Santos J. E.
Published: November 2007

An iterative algorithm based on a full‐Newton method for the estimation of the saturated hydraulic conductivity k from drainage experiments is presented. The water flow in the unsaturated zone is assumed to be described by Richards equation and the well‐known van Genuchten constitutive model. The cost functional used for the parameter optimization is defined as the L2‐error between the calculated pressure head values and the observed data at discrete points in the soil profile during the drainage process. The derivative of pressure head with respect to the parameter k is obtained as the solution of a differential equation with appropriate boundary and initial conditions. A Galerkin finite element procedure is used to obtain approximated solutions of the two differential problems involved in each iteration: the direct problem and the derivative of the functional. The algorithm was implemented in one‐dimensional domains and used to estimate k in layered soils using both synthetically generated data and observed data from an experimental plot in the Azul River basin (Buenos Aires, Argentina). Numerical examples show that the proposed algorithm yields very good estimations of the saturated hydraulic conductivity and becomes a promising method for in situ estimation of this parameter. Copyright © 2007 John Wiley & Sons, Ltd.