bluuebunny/crossref_metadata_2025 huggingface dataset:
Trabajar con publicaciones periódicas en Argentina
Authors:   Universidad Nacional de La Plata, Instituto de Investigaciones en Humanidades y Ciencias Sociales / CONICET, Delgado Verónica
Published: August 2022

De un tiempo a esta parte se han venido produciendo cambios significativos en relación con la circulación y las posibilidades de acceso a las publicaciones periódicas. En Argentina tenemos desde las ediciones facsimilares en papel de finales de la década de 1990 (por ejemplo, las de la Universidad de Quilmes o del Fondo Nacional de las Artes) pasando por las ediciones digitalizadas en formato cd a cargo de instituciones de gestión privada y estatal. A partir de comienzos del siglo XXI, esas instituciones combinaron la edición facsimilar en papel con la edición digitalizada, hasta conformar lo que podría denominarse una nueva era del archivo en el marco de las políticas de acceso abierto a nivel local y global. El efecto propiciador de esas políticas sobre las investigaciones en publicaciones periódicas es evidente y refuerza el interés sostenido, desde al menos veinte años a esta parte, que consolidó un ámbito de convergencia de intereses multidisciplinares y de líneas de investigación.
Kitab Rukun Istinjak: Integration of Fiqh and Sufism in the Early 19th Century of West Borneo Hinterland
Authors: Amin Faizal
Published: August 2022

Kitab Rukun Istinjak [Book on the Procedure for Cleaning the Private Parts after Relieving Oneself] is a manuscript that originated from interior Borneo of West Kalimantan in the early 19th century. The text describes the concepts of fiqh [Islamic jurisprudence], which provides not only technical explanations for the implementation of rituals but also a description of philosophical concepts for the consumption of the heart/soul. The context of the private collection of manuscripts is for a minimal audience, namely the sālik [follower of Sufism] who study and practice the teachings of Sufism in the way of Nūr Muḥammad [Light of Muhammad]. This Rukun Istinjak manuscript records Islamic teachings, which show the integration of Islamic jurisprudence into Islamic mysticism, which initially developed in hinterland Borneo. Even though the text indicates the existence of Sufistic-style Islamic teachings adopted by the indigenous Muslim community of West Kalimantan in the Putussibau area, in particular, there are no clues that explain their affiliation or relations with a specific tariqa order.
Risk factors and outcomes of emergency intervention in pregnant women with placenta previa: an observational study
Authors: KELEŞ Ayşe , AYDOĞMUŞ Süheyla , YUCEL CELİK Ozge , DAGDEVİREN Gulsah , OBUT Mehmet , ÇELEN Şevki , ÇAĞLAR Ali
Published: August 2022

Aim: To investigate the risk factors and outcomes of emergency intervention in pregnant women with placenta previa (PP).

Material and method: This retrospective study was conducted between June 2015 and January 2021. Pregnant women with PP were divided into emergency and planned intervention groups according to surgical planning. The groups were compared in terms of demographic characteristics, presence of antepartum hemorrhage (APH), operation characteristics, and maternal and neonatal outcomes.

Results: A total of 434 patients with PP were analyzed. The frequency of PP was 0.52%. The emergency intervention was performed in 168 (38.7%) pregnant women, whereas planned intervention was performed in 266 (61.3%). APH was present in 208 (47.9%) patients; the presence of APH was associated with increased risk of emergency intervention by 3.026 [95% confidence interval (CI), 1.990–4.603; p = 0.000]-fold. The weight gained during pregnancy was associated with reduced risk of emergency intervention by 0.932 (95% CI, 0.887–0.978; p = 0.004)-fold. In the emergency intervention group, more additional surgical procedures and massive transfusion were performed during the operation (p = 0.000 and p = 0.000) Emergency intervention resulted in an increase in adverse maternal and fetal outcomes by 3.064 (95% CI, 1.571–5.975) and 7.5 (95% CI, 4.841–11.620)-fold, respectively.

Conclusion: The frequency of an emergency intervention is high in those with PP and is associated with increased adverse maternal and neonatal outcomes.The most effective factor in the prediction of emergency intervention is APH.
Erken COVID-19 pandemisi sürecinde Osmangazi Üniversitesi Cerrahi Onkoloji ve Gastroenteroloji Cerrahisi Bilim Dallarında elektif olarak yapılan ameliyatların profili
Authors: KARAKAYA İhsan , ÖZDEMİR Ümit , ÖZDEMİR Dursun , KARAYİĞİT Ahmet , DİZEN Hayrettin , ÜNAL Bülent
Published: August 2022

Covid-19 pandemisi dünyada ve ülkemizde sağlık hizmetlerinin sunumunu etkilemektedir. Dünyada sağlık hizmetlerinin aksamış ve elektif cerrahiler durma noktasına gelmiştir. Sağlık hizmetlerinin önemli birimlerinden biri olan ameliyathaneler bazı ülkelerde ve bölgelerde yoğun bakım yataklarına çevrilmiş ve kanser hastaları ve acil hastalar dahil cerrahi hizmet verememişler ve buna bağlı olarak hastalar mağduriyet yaşamışlardır. Nitelikli sağlık hizmetinin en önemli parçası olan cerrahi kliniklerde durma noktasına gelen ameliyatların tekrar başlaması için hastanelerin pandemi etkisinden kurtulması ve sağlık sistemi üzerindeki yükün azalması gerekmektedir. e Ülkemizde ertelenmesi mümkün olmayan kanser cerrahisi ve acil cerrahi alanlarında Osmangazi Üniversitesi Gastroenteroloji Cerrahisi ve Cerrahi Onkoloji Bilim Dalları olarak yaklaşık 4 aylık süreçte 79 hasta ameliyat etmiş olup bu ameliyatlarla ilgili genel bilgileri paylaşıyoruz.
Can Serial Internal Optic Nerve Sheath Diameters Measured with Ultrasonography Predict the Prognosis of Medical Intensive Care Patients?
Authors: ÖZDEMİR Uğur , YILDIZ Şeyma , TANBUROĞLU Derya , TÜRKOĞLU Melda , AYGENCEL Gulbin
Published: August 2022

Aim: Optic nerve sheath (ONS) contains subarachnoid space, pia mater layer, and optic nerve fiber layer. ONS diamater (ONSD) without subarachnoid space is known as internal ONSD (iONSD). There are too many astrocytes and vascular network in iONSD area. Astrocytes are known to swell with systemic infection, inflammation, pro-inflammatory cytokines, some metabolic disorders, and oxidative stress. Also, this vascular network can vary by many ICU pathologies. This study investigated the relationship between serial iONSD measured with USG and the prognosis of critically ill patients who had no intracranial pathologies.

Material and method: The mean iONSD values for the right eye (RiONSD) and left eye (LiONSD) were measured. MiONSD (the mean of RiONSD and LiONSD) and DiONSD (the difference of final and admission MiONSD of ICU stay) were calculated.

Results: 35 ICU patients without intracranial pathologies were included. There was a significant difference between survivors and non-survivors for DiONSD (-0.35 [(-0.85)-(-0.10)], 0.60 [(0.21)-(1.00)] mm respectively, p=0.0001). The multivariate analysis performed between DiONSD, SOFA, and APACHE II score (p=0.033, OR=10.66 %95 CI [1.21-93.92]) indicated that DiONSD was an independent risk factor for mortality. DiONSD values greater than + 0.25 mm was determined to be a predictor of mortality with 75% sensitivity and 95% specificity (LR=14.25, AUC=0.905, p=0.0001). There was a good corelation between DiONSD values and SOFA score, total fluid balance, sepsis, serum albumin level, and GCS level.

Conclusion: iONSD measurement with USG can be used to determine the prognosis of ICU patients who have no intracranial acute or chronic pathologies.
Credit Risk in Islamic Banking
Authors: Kusnandar Acu
Published: August 2022

The application of sharia principles in banking, which does not involve the elements of interest (riba), betting (qimar), and uncertainty (gharar) is unique and draws attention, resulting in an increase in popularity of this type of banking. Financing products have also emerged with a variety of services. Although Islamic banking does not involve those three elements, it is still faced with the risk of disbursed financing. This issue is important to observe considering its relationship with growth and competitiveness in the banking industry. Credit risk that arises can be caused by two factors, including unsystematic and systematic factors or those that cannot be eliminated or controlled. Several previous studies have described the elements that can put a bank’s credit at risk, particularly in the case of Islamic banking. Therefore, this research using a literature study aimed to classify factors that can indicate credit risk, both systematic and unsystematic in Islamic banking.
Pro-Cyclicality of Provisions for Loan Losses
Authors: Lim Kwangsoo
Published: August 2022

The crux of bank accounting is how to measure and disclose ex ante credit risk, as loan yields and cost of funds are determined by managerial effectiveness and the financial market. This paper examines how the practice of setting up provisions for loan losses by bank managers had changed to preserve regulatory capitals around the 2008 financial crisis. This paper examines the empirical relationship between ex ante credit loss, which is proxied by loan losses provisions, and realized credit loss, which is measured by net charge-off. The empirical relations are examined before, during, and after the 2008 financial crisis to find the patterns of prediction errors of the incurred loss model. This paper obtains evidence that the empirical relation between non-performing assets and provisions for loan losses weakened at the time of a financial crisis. The relations of net charge-offs and allowance for loan losses on provisions for loan losses amplified during a financial crisis by accounting design. After the financial crisis is over, the empirical relation between non-performing assets and provisions for loan losses does not return back to the pre-crisis relation, but to a different, new post-crisis relation. This paper obtains evidence that financially stable banks in terms of the tier 1 capital ratio, return on assets, market-to-book ratio, or dividend payout ratio tend to adjust provisions for loan losses in a larger scale in response to a financial crisis than less stable banks.
MIG WELDING OF AUSTENITIC 316L STEEL USED IN MEANS OF TRANSPORT
Authors: SZCZUCKA-LASOTA Bożena , WĘGRZYN Tomasz
Published: August 2022

The austenitic 316L steel (1.4401) is an important stainless material used to build various means of transport. Austenitic steel has high resistance to atmospheric corrosion. The austenitic steel is treated as a good weldable material, although cracks are possible. This paper analyses the influence of various MIG welding parameters on the creation of correct joints used in the stainless steel structures of mobile platforms elements, as an example of welding structures, in various means of transport. Various tests verifying the mechanical properties of MIG welds, including non-destructive tests, tensile strength and hardness tests, were carried out. This article aims to show how important and complex the task is to select the correct welding parameters for elements of means of transport made of austenitic steel on the example of elements of mobile platforms.
AN INNOVATIVE METHOD IN MEASURING PERMEABILITY AND EVAPORATION PARAMETERS IN POROUS PAVEMENTS WITH EMPHASIS ON ITS EFFECTS ON INCREASING URBAN TRANSPORT SAFETY
Authors: GHAFOURI FARD Zohra , KHABIRI Mohammad Mahdi , AFKHAMI MEYBODI Pouya
Published: August 2022

Today, the increasing development of urbanization and climate change and its resulting issues, including the occurrence of urban floods, is one of the important issues facing city managers. One of these problems that seriously affect lives today is the occurrence of floods and the inundation of urban thoroughfares. Among the problems of floods in urban areas are the disruption of the urban transportation system, reduced transportation safety, inundation of thoroughfares, and consequently, the poor appearance of urban roads. One of the successful strategies in controlling urban runoff is the use of porous pavements in urban thoroughfares. The two capabilities of permeability and evaporation of a porous pavement lead to reduced runoff and a resultant lack of occurrence of inundation of thoroughfares; therefore, accurate measurement of these two parameters is of special importance. This study aims to introduce two devices for measuring the permeability and evaporation of porous asphalt with an innovative method that can measure the permeability and evaporation of asphalt and porous concrete with appropriate accuracy.
Ecological model development : Toolkit for interActive Modeling (TAM)
Authors: Carrillo Carra , McKay S. , Altman Safra , Swannack Todd
Published: August 2022

Ecological models provide crucial tools for informing many aspects of ecosystem restoration and management, ranging from increasing understanding of complex ecological functions to prioritizing restoration sites and quantifying benefits for project reporting. The diversity of ecosystem types and restoration objectives often precludes the use of existing models; as such, model development is commonly required to inform restoration decision-making. Index-based habitat models are a common approach for assessing ecosystem condition. These models relate habitat quality to species’ distributions. Habitat suitability (quality) typically ranges on a scale from 0 to 1. Habitat models have been developed to assess habitat suitability for specific taxa, communities, or ecosystem functions. Restoration-project timelines often require that these models be developed rapidly and in conjunction with many external stakeholders or partners. Here, the Toolkit for interActive Modeling (TAM) is proposed as a platform for rapidly developing index-based models, particularly for US Army Corps of Engineers’ (USACE) ecosystem-restoration or mitigation planning processes. The TAM is a consistent quantitative framework that allows for development of a generic platform for index-based model development.
Prediction of Mine Water Inflow based on the Coupled Flow Characteristics of Multiple Water Conducting Structures
Authors: Zhao Jinhai , Liu Qi , Jiang Changbao , Wang Defeng
Published: August 2022

Because of various patterns of deep-water inrush and complicated mechanism, accurate prediction of mine water inflow is always a difficult problem for coal mine geologists. In this paper, the water inrush channel is divided into four basic water diversion structures: aquifer, rock fracture zone, fracture zone and goaf. The fluid flow characteristics in each water conducting structure were investigated by laboratory test and the multi-structure and multi-system coupling flow analysis model of different water conducting structures are established to describe the whole process of water inrush. Based on the research of water inrush flow path, the analysis model of different water inrush space structure was established and applied to the prediction of mine water inrush inflow. The results prove that, (1) the conduction sequence of different water-conducting structures and the changing rule of permeability caused by stress changes before and after the peak have important influences on the characteristics of mine water-gushing. Influenced by the difference of geological structure and combined with rock mass RQD and fault conductivity characteristics and other mine exploration data, the prediction of mine water inflow can be realized accurately. Take the water transmitting path in the multi-structure as the research object of water inrush, breaking through the limitation of traditional stratigraphic structure division, the prediction of water inflow and the estimation of potential flooded area was realized and water bursting intensity was predicted. It is of great significance to make a reasonable emergency plan.
Reduction of dental biofilm cariogenicity in patients with fixed orthodontic appliances by a combined Horizontal-Charters-modified Bass brushing technique and dietary advice: A randomized clinical trial
Authors: Saengphen Thanakorn , Koontongkaew Sittichai , Utispan Kusumawadee
Published: August 2022

Background: The orthodontic patients with inadequate oral hygiene have susceptibility to dental caries. Increased dental biofilm accumulation has been found in orthodontic patients. However, assessment of dental biofilm cariogenicity in these patients has not been reported. This open-label, two-arm parallel trial evaluated the effects of toothbrushing and dietary advice on dental biofilm maturity and dietary habit in patients with stainless steel (SSL) and elastomeric (EL) ligatures.Methods: At T0, diet habits, socio-demographic, medical problems, orthodontic treatment, and dental health behavior data were collected from 70 patients. The patients were randomized (1:1 ratio) to the SSL or EL group by simple randomization at T1. Dental biofilm cariogenicity was evaluated using a three-color-disclosing dye. The patients in both groups were instructed to brush their teeth using a combined Horizontal-Charters-modified Bass technique and dietary advice. The data were reassessed at the 4-week follow-up (T2). Results: At T1, new dental biofilm (median 50%; Q1, 32.66%; Q3, 71.13%) was highest followed by mature dental biofilm (median 26%; Q1, 20.42%; Q3, 47.93%), and cariogenic dental biofilm (median 8%; Q1, 4%; Q3, 22.92%) (p < 0.05), in SSL group. In the EL group, cariogenic dental biofilm (median 54.16%; Q1, 44.44%; Q3, 69.56%) was highly observed, while the median for mature and new dental biofilm was 25.0% (Q1, 18.18%; Q3, 36.18%) and 13.63% (Q1, 7.55%; Q3, 26.96%), respectively (p < 0.05). At T2, cariogenic dental biofilm in EL group demonstrated significantly greater reduction (47.04%) compared with the SSL group (8%) (p < 0.05). Cariogenic food consumption was low in two groups. However, dietary habits did not change in either group at T2.Conclusions: Combined toothbrushing effectively reduced cariogenic dental biofilm in orthodontic patients. Trial registration Thai clinical trials registry (TCTR20220221003)
Characterization of Synthesized Cellulose Derivatives in 1-Butyl-3-Methylimidazolium Chloride Ionic Liquid
Authors: BAKER MARIAM TEMITOPE
Published: August 2022

To obtain pure holocellulose, cellulosic wastes were chemically pretreated. Depending on the derivatizing agents used, the dissolution and functionalization of various holocelluloses obtained in 1-butyl-3-methylimidazolium chloride [BIMIM]Cl ionic liquid using different derivatizing agents such as cellulose acetate, cellulose phthalates, and cellulose ether. Cold acetone and dichloromethane were used to regenerate the dissolved product in ionic liquids, and the resulting ionic liquids were reused.The degree of substitution (DS) of the products obtained ranged from 1.00 to 2.77 at 100°C. FTIR analysis revealed important absorption bands which include: (C = O at ~ 1750 cm− 1, SP3 –CO at ~ 1250cm− 1, SP2 –CO at 1100cm− 1, for esters of cellulose acetate and phthalate, Aromatic –CH stretching at 1577cm− 1 for cellulose phthalate and –CO-CH2CH3 at 1720cm− 1 with the absence of SP2 bending frequency at 1250cm− 1 which confirms the successful synthesis of ethyl cellulose). XRD showed values at (2θ= ~14.5°, 17.0°, 22.7° and 34.5°) for all samples. Comparison of SEM images of the cellulose and derivatives showed little or no destruction of the fibre strands while EDS revealed C and O as (Elemental composition of all samples. Thermogravimetric analysis (TGA/DTA) showed the derivatives possessed higher thermal stability that the starting materials thus, producing materials with better application. All these revealed a successful extraction and purification of cellulose from wastes as well as the synthesis of cellulose derivatives.
Subthreshold Laser Treatment for Non-Center Involved Diabetic Macular Edema via Non-Damaging Retinal Laser Therapy (NRT)
Authors: Aydoğmuş Fatma Akkan , Kalaycı Defne , Gultekin Burcu Polat
Published: August 2022

Background/Objectives: To evaluate the efficacy of subthreshold laser treatment via NRT in patients with non-center involved diabetic macular edema (non-CI DME).Methods: In this prospective controlled study, NRT with 577 nm wavelength was performed to the edematous inner subfields as needed at 3 monthly intervals, while the control group received no treatment. If CI-DME developed in either group, intravitreal anti-VEGF was performed and the eye was excluded from subsequent analysis. Results: A total of 75 eyes (36 study eyes, 39 controls) were evaluated. The change in superior, nasal and temporal inner subfield thicknesses over time and between groups was found significant (P=0.004, P<0.001, P=0.04 respectively). Best corrected visual acuity (BCVA) change was not significant over time and between groups (P=0.69). Rates of CI-DME development requiring intravitreal anti-VEGF treatment were not different during the first and second years (P= 0.171, 0.908). No laser scar was detected in any eye in fundus autofluorescence imaging.Conclusion: NRT performed as needed at 3 monthly intervals is effective after 21 months of follow up in the treatment of non-CI DME and it was safe. With this method, it may be foreseen that BCVA will be better preserved in the long term by avoiding the possible side effects of conventional laser.
The responsibility of the EU in climate change mitigation: What is wrong with the recent EU targets?
Authors: Suárez-Eiroa Brais , Soto-Oñate David , Loureiro Maria
Published: August 2022

The European Union (EU) is a leading actor in climate international negotiations and a path-breaking example of sustainability. However, the EU’s current agenda on climate change has been built by disregarding essential features of this global process: accumulation of greenhouse gases over time, cascading regimen shifts within and across scales, and tipping points. We examine whether the EU’s recently declared climate targets are consistent with a reasonable allocation of responsibilities concerning global carbon budgets. This is relevant because the assumption of appropriate climate responsibilities is paramount for the collective coordination of polycentric actions towards the agreed common goal. We find that the current EU climate policy is inconsistent with the aspiration of preventing the +1.5 °C or +2 °C average global temperature increase in 2100, compared to preindustrial levels. We argue that the EU should aim for more responsible policies coherent with its responsible share of the global budget.
Thermal diffusion and diffusion thermo impacts with Cattaneo – Christov theories on the peristaltic motion of a non – Newtonian micropolar nanofluid inside a tapered stenosis artery
Authors: El-Dabe Nabil T. M. , Abouzeid Mohamed , Ouaf Mohmoud , Mostapha Doaa R. , Mohamed Yasmeen M.
Published: August 2022

The current investigation described the influences of Cattaneo – Christov heat flux, Soret and Dufour, Hall current. The vertical alternating current produces an electric field is applied on the peristaltic flow of non - Newtonian micropolar nanofluid. The fluid flows inside a tapered stenosed artery. The non – Newtonian fluid obeys the tangent hyperbolic model. The effects of heat generation absorption, joule heating, thermal radiation, chemical reaction, and the permeability of the porous medium are imposed. The slip velocity and thermal slip conditions are assumed. The convective conditions for nanoparticles concentration as well as concentration are constructed. The coupled differential systems of equations yield Soret and Dufour feature. The assumption of the long wavelength with low Reynolds number is employed to simplify the governing equations of fluid motion to be ordinary differential equations. Furthermore, the obtained analytical solutions of these equations are based mainly on applying regular perturbation method together with homotopy perturbation method (HPM). The impacts of the various physical parameters on the axial velocity, spin velocity, temperature, nanoparticles concentration and concentration are illustrated and drawn graphically via a set of graphs. It is noticed that the velocity dwindled with an enriching in the magnitudes of both Hartman number, and electromagnetic parameter. Whereas, the axial velocity elevates with an enlargement in Darcy number, tapering angle, and Hall parameter. Moreover, the spin velocity declines with the increment in the microrotation parameter. Also, it is found that the escalating in thermal relaxation time causes a decaying impact on the temperature. Furthermore, enhancement in the nano Biot number leads to a declination in the magnitude of nanoparticles concentration. The current analytical study is very significant in several medical implementations, like the gastric juice motion in the small intestine when an endoscope is inserted through it.
Penetration Study Of p-Methoxycinnamic Acid (PMCA) in Nanostructured Lipid Carrier, Solid Lipid Nanoparticles, and Simple Cream into the Rat Skin
Authors: Rosita Noorma , Sultani Angguni Addini , Hariyadi Dewi Melani
Published: August 2022

This study compared the ability of NLC, SLN, and cream systems in delivering Para Methoxycinnamic Acid (PMCA) to the dermis layer of the skin. Wistar rats were used as research subjects. NLC and SLN were made using the high shear homogenization method. Red nile was used as a penetration indicator based on its fluorescence. The interaction between fluorescence labeled NLC, SLN, or simple cream and rat skin was visualized by fluorescence microscopy. Observations were done after 2 and 4.5 hours of smearing the test sample. From observations, it was known that the system/lipid base could penetrate the stratum corneum delivering drugs. Penetration speed differs between systems as does the number of PMCAs that can be delivered. In this study, it can be concluded that the NLC system is able to deliver PMCA more quickly and in greater quantities to the dermis than SLN and Cream.
WITHDRAWN: Extension typologies and sustainable intensification:
Evidence from West Africa
Authors: Tabe-Oj Martin Paul Jr , Gebrekidan Bisrat , Lokossou Jourdain , Nyam Sebastian
Published: August 2022

Agricultural productivity and environmental sustainability are two important complementary sustainable development goals. However, potential trade-offs could exist in some production and farming systems. Sustainable intensification offers the promise of both increasing agricultural productivity and maintaining environmental sustainability, but its current use is puzzlingly low in many regions of the world, possibly due to information constraints. This paper examines the relationship between different typologies of extension systems and the use of sustainable intensification practices in three West African countries: Ghana, Mali, and Nigeria. Exploring the longitudinal nature of the dataset, we show that farmers with access to extension services are more likely to use sustainable intensification practices such as high-yielding and disease-resistant varieties, crop rotation, and intercropping with cereals, as well as the use of organic fertilizers. These relationships hold true for both farmers that are advised by both private and public extension agents. However, the biggest intensification gains are observed for farmers that are jointly advised by both private and public extension systems. Exploring what may be underlying the relationship between the different extension typologies and sustainable intensification, we find suggestive evidence that agricultural training may partly explain this positive relationship. Based on these insights, we conclude that farmer extension services and farmer advisory systems matter in bridging the trade-off between agricultural production and environmental sustainability.JEL codes: I38; J54; Q13; Q16
The estrogenic effect of Lysiphyllum strychnifolium (Craib) A. Schmitz water extracts in MCF-7 cells
Authors: Maenpuen Suwanna , Ekaratcharoenchai Niramai , Mongkolrob Rungrawee , Nualsanit Thararat , Kietinun Somboon , Krajarng Aungkana
Published: August 2022

Background
Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) has been used to stimulate breast milk production in women after giving birth in the Northeast of Thailand. However, very little information is known about its estrogenic effect. The present study investigated the estrogenic effect of LS leaves water extracts compared with quercetin, one of the major compounds in LS, in MCF7 human breast cancer cells
Methods
The effect of LS leaves water extracts and quercetin on cell proliferation of estrogen receptor (ER)-positive breast cancer cells, MCF-7, was studied by MTT assay at a concentration range of 0 to 500 µg/ml. The expression of estrogen-dependent genes, the pS2, ERα, ERβ and Bcl-xL, were also examined by real time RT-PCR, and the expression of ERα protein was detected by Western blotting.
Results
The quercetin content in LS water extract was 285.67 ± 0.11 ug/g. The expression levels of the pS2 and Bcl-xL genes in MCF-7 cells were found to be upregulated by LS leaves water extract (20 µg/ml) and 17β-estradiol (E2) (10− 5 M) compared with the untreated control. The ERα gene expression was found to be upregulated by quercetin (0.16 µg/ml) and E2 (10− 5 M) compared with the untreated control. In addition, quercetin (0.16 µg/ml) and LS extract (0.8, 4, 20 µg/ml) decreased the phosphorylation of ERα at Ser167 (pERα (ser167)) and LS extract (20 µg/ml) decreased ERα, but there was no significant effect on the ERα at Ser118 (pERα (ser 118)) protein expression.
Conclusions
This study provided evidence for the potential estrogenic activities of LS leaves water extract. Since LS extract induced pS2 gene transcription, it was confirmed that the extract could affect the transcription of estrogen responsive genes causing estrogenic effects. The results also showed that quercetin, one of the LS compounds, upregulated ERα gene expression at 24-hour treatment.
High level of FANCI correlates with worse prognostic outcome and promotes tumor growth of lung adenocarcinoma partly by suppressing the activation of M1 macrophages
Authors: Li Wujin , Yu Mingdian , Zhang Jiguang , Huang Jianyuan , Lin Zhaoxian , Chen Jingbo , Jiang Guicheng , Lin Xing
Published: August 2022

FANCI, as a member of the Fanconi anemia (FA) complementation group, normally associates with FANCD2 to play an important role in ribosome biogenesis and DNA repair. However, the correlation of FANCI to prognostic value and the molecular mechanism in lung adenocarcinoma (LUAD) patients remain unclear. In the present paper, bioinformatics analysis was performed on LUAD data from TCGA and GEO database, and further to be confirmed by in vitro experiment. We found that high level of FANCI was significantly correlated with worse survival probability of LUAD patients. Moreover, the results from in vitro experiments revealed that high levels of FANCI were found in LUAD specimens and LUAD cell lines. Knockdown the expression of FANCI in A549 cells and H460 cells significantly inhibited the cell viability and clone formation of LUAD cells in vitro and in vivo. Furthermore, high FANCI level was negatively correlated with a variety of the tumor infiltrating immune cells. Importantly, overexpression of FANCI significantly inhibited the activation of M1 macrophages. All the data demonstrated that FANCI was a useful prognostic biomarker in LUAD patients and knockdown FANCI inhibited tumor growth of LUAD cells in vitro and in vivo partly by suppressing the activation of M1 macrophages.
Revisiting mandibular symphyseal shape in juvenile early hominins and modern humans using a deformation-based approach
Authors: Zimmer Veronika , Oettlé Anna , Hoffmann Jakobus , Thackeray John Francis , Zipfel Bernhard , Braga José
Published: August 2022

The juvenile mandible is important in the investigation of ontogenetic and evolutionary changes among early hominins. To more accurately describe complex shape variations, for the first time advanced methods from computational anatomy, and new fossil evidence are used to revisit the ontogeny of the mandibular symphysis in Australopithecus africanus and Paranthropus robustus. We assess which features of the mandibular symphysis best discriminate the growing symphysis in these fossil species, relative to the intraspecific variation observed among modern humans. When compared with more traditional approaches, our results are in line with previous studies and confirm that our approach eliminates potential methodological inconsistencies with the a priori definition of homologous landmarks and the tacit assumption that anatomical shapes are linear. By enabling detailed comparisons of complex shapes in juvenile mandibles, our proposed approach offers new perspectives for more detailed comparisons among Australopithecus, Paranthropus and early Homo in both southern and eastern Africa.
Antimicrobial susceptibility patterns and molecular characterization of plasmid-mediated quinolone resistance determinants among Salmonella and Shigella spp. isolated from pediatric patients
Authors: Mirzaii Mehdi , Alebouyeh Masoud , Sohrabi Mohammad Bagher , Eslami Parisa , Fazli Mojgan , Bazobandi Zahra , Rashidan Marjan
Published: August 2022

Background: Diarrhea remains a serious public health problem, which could be life- threatening in children. Salmonella and Shigella are among the main responsible agents. Fluoroquinolones are the most common antibiotics prescribed to treat these infections; however, increasing rate of resistance and its spread through plasmid- mediated quinolone resistance (PMQR) genes should be considered for medication in each country. To achieve this aim, the current study was conducted to determine the frequency of PMQR genes in Shigella and Salmonella isolates of pediatric patients with acute diarrhea. Methods: In this study, Shigella and Salmonella isolates from fresh stool samples of diarrhea patients were included from May 2017 to May 2018. All the isolates were characterized by conventional phenotypic and molecular methods. The antibiotic resistance profiles and the frequency of PMQR genes were determined by standard susceptibility and molecular test methods. Results: The highest antibiotic resistance rate among Shigella and Salmonella isolates was related to trimethoprim-sulfamethoxazole (37/40; 92.5%) and cefoxitin (5/45; 11.1%), respectively. Although qnrS, qepA, and aac (6¢)-Ib-cr genes were characterized in 32.5%, 2.5%, and 2.5% of the Shigella strains, qepA (17.7%) and qnrS (4.4%) were among the common PMQR determinants in the Salmonella isolates, respectively. The reduced susceptibility to ciprofloxacin was detected among 25% and 22.2% of PMQR-harboring strains of Shigella and Salmonella, respectively. Conclusion: Low rates of ciprofloxacin resistance and low frequency of MDR Salmonella and Shigella isolates were characterized in this study. Most of the isolates that carried PMQR determinants presented only low-level resistance and reduced susceptibility to ciprofloxacin.
Vagus Nerve Stimulation Attenuates Acute Kidney Injury Induced by Hepatic Ischemia/Reperfusion Injury by Suppressing Inflammation, Oxidative Stress, and Apoptosis in Rats
Authors: Deng Simin , Zhang Yifeng , Xin Ying , Hu Xinqun
Published: August 2022

Hepatic ischemia reperfusion (I/R) injury, caused by limited blood supply and subsequent blood supply, is a causative factor resulting in morbidity and mortality during liver transplantation (LT) and liver resection. Hepatic I/R injury frequently contributes to remote organ injury, such as kidney, lung, and heart. It has been demonstrated that vagus nerve stimulation (VNS) is effective in remote organ injury after ischemia reperfusion injury. Here, our aim is to investigate the potential action of VNS on hepatic I/R injury-induced acute kidney injury (AKI) and explore its underlying mechanisms. To test this hypothesis, male Sprague-Dawley rats were randomly assigned into three experimental groups: Sham group (sham operation, n=6); I/R group (hepatic I/R with sham VNS, n=6); and VNS group (hepatic I/R with VNS, n=6). VNS was performed during the entire hepatic I/R process. Our results showed that throughout the hepatic I/R process, VNS significantly reduced inflammation, oxidative stress, and apoptosis, and greatly enhanced the protein expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and hemeoxygenase-1 (HO-1) in the kidneys. These findings suggest that VNS may ameliorate hepatic I/R injury-induced AKI by suppressing inflammation, oxidative stress, and apoptosis probably through activating the Nrf2/HO-1 signaling pathway.
Prior combined dehazing network based on mutual learning
Authors: Qiao Dong , Kong Xiangtong , Kong Lingjian , Liu Jifang , Mi Wenpeng , Meng Shenghao
Published: August 2022

Single image dehazing is an important problem for high-level computer vision tasks since the existence of haze severely degrades the recognition ability of computers. Most recent works tend to combine prior-based dehazing method with a convolutional neural network (CNN) to improve the dehazing effect in real scenes. However, these methods do not tackle with the color shifts caused by prior-based methods effectively. In this paper, we propose a prior combined dehazing (PCD) network based on mutual learning. Specifically, we build two sub-networks to achieve dehazing by both supervised and unsupervised ways. The supervised sub-network is optimized by ground truth, which provides color fidelity but may acquire under-dehazed images when applied to real scenes; The unsupervised sub-network is optimized by the dehazed images of dark channel prior, which improves the generalization ability but introduces some color shifts or artifacts. Since the dehazed of these two sub-networks show complementary advantages, a mutual learning mechanism is built for the joint optimization. And we propose a feature fusion module based on the perceptual differences to acquire the final results. The experimental results demonstrate that our method surpasses previous state-of-the-arts on both synthetic and real-world dataset.
Incidence of major cardiovascular events at 1, 2, 5 years and mortality in incident patients on peritoneal dialysis regarding their nutritional status by bioimpedanciometry. A multicenter study in Colombia
Authors: Torres Rodolfo , Reina Maricely , Olivares Orlando , Rosselli Carlos , Montoya María , Reales Marginis , Andrade David , Centeno Carlos , Briceño Robert , Buitrago David , Hernández Leonardo , Morales Jesús , Delgado Caterin , gresott Ella , Gutiérrez Gerardo , Molina Carolina
Published: August 2022

Background: The nutritional status of incident patients on peritoneal dialysis (PD) has been associated with survival outcomes. Bioimpedanciometry (BCM) enables to establish a nutritional diagnosis, the volume status, and correlates these findings with survival (1). Methods: Retrospective multicenter historical cohort study. Results: In this study, which included 420 incident patients on peritoneal dialysis with a 5-year follow-up, a cumulative incidence of major adverse cardiovascular events (MACE) of 28.8% was found; being higher in the diabetic population at 36.8%. In regard to the nutritional status in this population, it was found that approximately 44% had altered nutritional status; 34% were found to be in sarcopenia, 6.7% sarcopenic obesity; and 2.8% in obesity (p < 0.001). In the survival analysis, a lower probability of survival was found in patients with overhydration (OH) greater than 3 liters (p<0.001) and in patients with altered nutritional status due to sarcopenia, sarcopenic obesity, and obesity (p 0.016). According to survival in the subgroup of the diabetic population, a lower probability of survival was found in this group of patients (p:0.011); The overall mortality of the study population was 18%, being higher in the first 2 years; thus finding that the most important causes of mortality were cardiovascular. Of the deceased population, 51% were diabetic patients (p:0.012) Conclusion: In incident patients on peritoneal dialysis, sarcopenic obesity, sarcopenia, overhydration status determined by BCM, and having a diagnosis of diabetes are related to a lower probability of survival; MACE outcomes are more frequent in the diabetic population.
Risk factors for sudden cardiac arrest in patients with ST-segment elevation myocardial infarction: a retrospective cohort study
Authors: Chu Chang-Hung , Shih Hong-Mo , Yu Shao-Hua , Chang Shih-Sheng , Sie Ji-Syuan , Huang Fen-Wei , Hsu Tai-Yi
Published: August 2022

Background
Sudden cardiac arrest (SCA) is a critical complication of acute myocardial infarction, especially ST-segment elevation myocardial infarction (STEMI). This study identified the risk factors for SCA in patients with STEMI before receiving catheterization.
Methods
We retrospectively analyzed the data of patients with STEMI and cardiac arrest who presented to a tertiary care center in Taiwan between January 1, 2016, and December 31, 2019. Only patients with coronary artery disease (CAD) confirmed by coronary angiography were included in this study. We collected the patients’ demographic and clinical data, such as age, sex, medical history, estimated glomerular filtration rate (eGFR), and coronary angiographic findings. The primary outcome of this study was SCA in patients with STEMI. Continuous and nominal variables were compared using the two-sample Student's t-test and chi-squared test, respectively. The results of logistic regression were subjected to multivariate analysis with adjustment for possible confounders.
Results
A total of 920 patients with STEMI and coronary angiography–documented CAD and 108 patients with SCA who presented between January 1, 2016, and December 31, 2019, were included. The bivariate logistic regression analysis of patients’ demographic data revealed that patients with STEMI and SCA were slightly younger, were more likely to have diabetes mellitus, and had lower eGFR than patients without SCA. The coronary angiographic findings indicated a higher prevalence of left main CAD and three-vessel disease in patients with SCA than in patients without SCA. Multivariate logistic regression revealed that left main CAD (odds ratio [OR]: 3.77; 95% Cl, 1.84 to 7.72), lower eGFR (OR: 0.97; 95% confidence interval [CI], 0.96 to 0.98), and younger age (OR: 0.98; 95% CI, 0.96 to 0.99) were the risk factors for SCA in patients with STEMI.
Conclusions
Left main CAD, lower eGFR, and younger age are the risk factors for cardiac arrest in patients with acute myocardial infarction.
An analysis of the utilisation of medical identification jewellery among children and young adults with type 1 diabetes mellitus in Australia
Authors: Heath Madeleine , Torpy David , Rushworth Louise
Published: August 2022

Aims
People with type 1 diabetes mellitus (T1DM) are at risk of life-threatening illness. Medical jewellery is recommended for emergencies, but its uptake is unknown. This study assessed the use of medical jewellery among people with T1DM aged 0–24 years in Australia.
Methods
A cross sectional analysis of subscription data to the largest medical identification jewellery service in Australia was analysed by age, sex and geographic location using Australian population data from 2018.
Results
There were 1599 people with T1DM aged 0–24 in the database, but only 1061 had an active subscription, corresponding to an active subscription rate of 13.28/100,000 population or approximately 5% of the estimated patient population. Half of the active subscribers were male (543/1061, 51/3%). The average age of active subscribers was 17; very few (n = 12, 1.1%) were aged less than 5; and the highest number (n = 141, 39%) was in the 20–24 age group. Active subscription rates varied significantly by geographic location. 88.4% of active subscribers had a diagnosis of T1DM or equivalent inscribed on their emblem, while engraved instructions for management in an emergency were only included in 1.8% of records (n = 19).
Conclusions
Medical jewellery subscription rates were lower than expected; increased with age; and varied significantly by state/territory. The use of medical identification jewellery may be limited by the lack of suitable engraved instructions for use in an emergency. Factors leading to low use should be addressed.
Inventory Model with Zero Defective Smart Production System
Authors: Miriam Renee , Martin Niventha , Anand M. Clement Joe
Published: August 2022

A smart production system is characterized by quality productive mechanisms integrated with technology. In this research work, a quality-centered inventory model with the objective of minimizing waste generation is formulated to develop zero defective productive scenarios. In this model, the repairable items are identified and classified into batches based on 4 levels of quality. Level 1 compromises products that are less than 25% defective. Level 2 consists of the remaining products which are up to 50% defective. Level 3 and Level 4 consist of products that are up to 75% and 100% defective. The model also comprises quality maintenance cost parameters with demand expressed as the function of quality and market price. The obtained optimal order quantity expression and annual net revenue is validated and sensitively analyzed with numerical data. The proposed model shall be extended with the inclusion of product distribution entities with respective cost parameters to formulate a more comprehensive quality and eco-centric inventory model.Mathematics Subject Classification 90B05, 90B30
Interference Aware Routing in Dynamic Mobile Adhoc Network with the Concern of QoS Factors in Military Information System
Authors: Vignesh V. , Elngar Ahmed A. , Gopalan Harihara
Published: August 2022

Military communications or military signals are involved with every aspect of communications, or the information transmission, by the military services. The capability for the receipt and usage of information holds high importance on the battlefield. MANETs (Mobile Ad hoc Networks) facilitate military communications by forwarding information to respective nodes at the correct time. But secured and robust communication has become the most crucial task in which the information transmitted to two troops fighting in the battery field via the same nodes may be disintegrated and data loss can happen. Several earlier studies have focused on interference-aware routing in a MANET environment. Military environments have mobile nodes while their infrastructure is more or less static, creating issues in interference-aware routings specifically when groups of soldiers disperse in different directions. This research work attempts to cross this hurdle and overcomes this issue with its proposed QoS-IRDMANET (Quality of Services and Interference aware Routing in Dynamic MANETs). Routes defined in this scheme consider QoS criterion along with interference conditions using a weighted sum method. This scheme renders priority in data communications by allocation of more bandwidths to respective communications at executions where critical information is immediately shared with corresponding troops. Moreover, path failures are also taken into account by this scheme owing to the unavailability of resources or node movements. The proposed scheme is demonstrated through simulations with satisfactory results when compared to earlier similar works in this area.
Existence of solutions for some classes of integro-differential equations on ${C^1}(\mathbb{R}_{+})$ by applying a measure of noncompactness
Authors: Tamimi Hengameh , Saiedinezhad Somayeh , Ghaemi Mohammad Bagher
Published: August 2022

This paper introduces sufficient conditions for the existence of solutions in some classes of integro-differential equations. Due to Darbo's fixed point theorem with an appropriate measure of noncompactness, we prove the existence of solution in each class of equations. Finally, some significant examples are solved using the artificial small parameter method.Mathematics Subject Classification (2010). 47H10, 45J05, 47H08.