bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis
Authors: Chu Cindy S. , Bancone Germana , Soe Nay Lin , Carrara Verena I. , Gornsawun Gornpan , Nosten François
Published: February 2019

Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs mandate daily primaquine dosing (the recommended regimen for G6PD normal individuals), then G6PD testing before prescription is necessary to avoid iatrogenic haemolysis in G6PD deficient individuals. In this case series, two P. vivax infected patients with unknown G6PD status from two different countries were prescribed primaquine as per national malaria program guidelines. During treatment both patients presented to the clinic with symptoms of anaemia after taking primaquine incorrectly. The clinical management of the iatrogenic severe haemolysis that occurred in these patients demonstrates the various adverse effects primaquine can cause, that other common medical treatments also have haemolytic potential, and how the diagnosis of G6PD deficiency can be elusive during acute haemolysis.

Health care providers should provide careful instructions about primaquine dosing, be watchful for haemolysis, and have a high index of suspicion for G6PD deficiency in the presence of haemolysis if the G6PD status is previously unknown.
Identity as a Communicative Project: “New Mythologies” in Modern Culture Space
Authors: Силантьева Маргарита , Silanteva Margarita
Published: February 2019

The article deals with the “identity” concept from the point of view based on cultural science and philosophy of culture, i.e. in a broader meaning of this notion as “sociocultural identity”. The latter is viewed not as a readymade “givenness” (national, ethnic, regional, local etc.) but as a dynamically forming social relations structure. It suggests inclusion into the researcher’s attention field the theory of structuration by Anthony Giddens as well as various forms of constructivism. Along with different approaches authors of mentioned theories have a point in common: the identity concept plays a specific role in political field connecting group integration models with individuals and groups behavior. Therefore “self-identity experience” (according to an initial identity definition in psychology) evolves into a culturological reflection on experience of this kind and formation of “new mythologies” determining “desirable future” (up to I. Young’s idea about delusiveness of any group identity and, as a consequence, a necessity to get rid of identity discourse). That starts in its turn a mechanism of “new mythologies” feedback effect on new identities formation. Among most common ideas of this kind “network identity” reflecting modern communication practices can be mentioned. “High tech society”, e.g. “transparent society” (D. Brin) is viewed by corresponding concepts authors as an ideal pattern, which could help to conform modern values contradictions by placing them into culture space where differences are recognized, where they have their place. Though analysis of each of the pointed out patterns demonstrates that “demand for differences” repressive potential is not less than fixation on one’s own culture and values exceptionalism. Hence the necessity to overcome an uncritical acceptance of new “identity mythologies” and consistent effort for their balanced estimate.
Legal management models
Authors: Осинцев Дмитрий , Osintsev Dmitriy
Published: February 2019

In this book there is not a single definition, as is typical for publications on traditional jurisprudence, here legal thinking is presented in its development, based not on abstract philosophizing and attempts to connect the legal life of society with the rigid framework of scientific laws. The preceding line of legal thinking is a ceaseless discussion of how to approach the understanding of law, otherwise the collision of methodologies, but not philosophizing, but discipline of the mind aimed at ensuring law and order is needed, therefore the way of working in the legal sphere is always dogmatic - exact and unquestioning execution of regulations supported by various security, guarantee, jurisdictional, deterrent and other means, while even changing the prescription itself is definitely subject to from dogma enshrined in procedural procedural rules.
Mankind builds the law and official jurisprudence in order not to be distracted each time to clarify the content and meaning of these phenomena. The right acts as a guideline of life positions of interested parties to the relationship. The law does not change the state of affairs that naturally took shape, does not create new laws of nature, economics, social life, etc., but can give them an official style, and nothing more.
The norms of law do not coexist along with other social norms, but give them socially significant official status, replace them, and also create innovations in the regulation of social activity. The right is a sign form of government invested with legal constructions, and the form is transformed. The right is accepted by society methods of invasion of the established socio-cultural situation and giving it a kind of conservative tradition after changing the natural course of affairs and replacing it with the normative management procedure.
MEMBUDAYAKAN HIDUP SEHAT MELALUI GERAKAN MASYARAKAT HIDUP SEHAT (GERMAS) DI DUSUN MENDANG III, JAMBU DAN JRAKAH KECAMATAN, TANJUNGSARI, GUNUNGKIDUL
Authors: Suryani Dyah , Nurdjanah Eka Putri , Yogatama Yogatama , Jumadil Muhamad
Published: February 2019

Kecamatan Tanjungsari merupakan salah satu kecamatan yang ada di Kabupaten Gunungkidul, Daerah Istimewa Yogyakarta dengan luas wilayah 7.161,1 hektar, 5.229 hektar (73,03%) berupa ladang tadah hujan, 1.351.1 (18,86%) berupa tanah tegal dan perkarangan dan 580,5 hektar (8,11%) berupa tanah lainya. Kecamatan Tanjungsari terdiri dari 5 desa, 71 Padukuhan, 71 RW, dan 300 RT. Jumlah penduduk sebanyak 28.788 jiwa terdiri dari 14.267 jiwa laki-laki dan 14.521 jiwa perempuan dengan jumlah kepala keluarga sebanyak 9.000 KK. Secara geografis Kecamatan Tanjungsari berbeda di ketinggian antara 100-300. Desa Hargosari dan Desa Ngestirejo adalah salah satu desa yang termasuk dalam kecamatan Tanjungsari. PermasalahanÂ yang terjadi diÂ Dusun Mendang III, Jambu Dan Jrakah Kecamatan, Tanjungsari, Gunungkidul ini adalah rendahnya pengetahuan melakukan PHBS (Pola Hidup Bersih dan Sehat) dalam menjaga kesehatan tubuh, sikap yang buruk dalam menyikapi pentingnya melakukan PHBS dalam kehidupan sehari-hari untuk mencegah terjadinya suatu penyakitÂ dan prilaku penerapan PHBS di kehidupan sehari-hari. Sehingga untuk meningkatkanya KKN tahun ini mempunyai topik kegiatan tentang meningkatkan kualitas sumber daya manusia menuju Pembudayaan Â Hidup Sehat Melalui Gerakan Masyarakat Hidup Sehat (GERMAS) Di Dusun Mendang III, Jambu Dan Jrakah Kecamatan, Tanjungsari, GunungkidulÂ agar menjadi masyarakat yang sehatÂ dan sadar akan pentingnya menjaga kesehatan dengan menerapkan PHBS. Metode pelaksanaan program KKN tahun 2018 inimeliputi : pendidikan masyarakat, difusi teknologi dan Program. Dampak yang didapat dari hasil kegiatan ini adalah 1). Bertambahnya pengetahuan tentang pentingnya menjaga kesehatan melalui gerakan masyarakat hidup sehat (GERMAS), 2). Meningkatnya kesadaran masyarakat tentangÂ pentingnya kesehatan dan PHBS, 3). Masyarakat dapat menerapkan langsung PHBS dalam kehidupan sehari-hari.
WISATA OUTBOUND DI GUNUNG GENTONG GEDANGSARI GUNUNG KIDUL
Authors: Sukesi Tri Wahyuni , Sulistyawati Sulistyawati , Mulasari Surahma Asti , Tentama Fatwa
Published: February 2019

Wisata budaya dan alam saat ini sedang banyak digemari oleh masyarakat. Wisata outbound adalah salah satu dari wisata budaya dan alam yang sedang banyak berkembang saat ini. Upaya untuk mengurangi tekanan pekerjaan dan hidup banyak sekali orang mencari tujuan wisata outbound yang murah. Salah satu tujuan yang ada di wilayah Gunung Kidul adalah Gunung Gentong, akan tetapi tujuan wisata outbound ini belum digarap dengan maksimal sehingga perlu dilakukan beberapa pelatihan bagi pengelolanya khususnya pelatihan permainan outbound yang berbasis pada dolanan anak di gunung Gentong.Metode yang digunakan adalah dengan pelatihan outbound yang berbasis pada dolanan anak tradisional secara langsung kepada pengelola wisata. Memberikan sumbangan peralatan yang digunakan dalam permainan permainan tersebut. Melakukan monitoring evaluasi setelah pelaksanaan pelatihan.Hasil yang diperoleh adalah kegiatan pelatihan berjalan dengan baik dan peserta aktif bertanya dan mengikuti kegiatan pelatihan sampai selesai. Pelatihan dilakukan dengan interaktif antara narasumber dengan peserta pelatihan
A CAPOEIRA E A ESCOLA: UM OLHAR ETNOGRÁFICO
Authors: Pereira Vinícius Oliveira
Published: February 2019

O artigo se propõe a discutir as implicações do diálogo entre uma escola da educação básica da rede municipal de ensino da cidade de Nova Iguaçu/RJ e a capoeira. Trata-se de uma etnografia das aulas de capoeira que envolveu diferentes sujeitos do espaço escolar: oficineira de capoeira, professoras e estudantes. A escola analisada trabalhou com a capoeira a partir do Programa Mais Educação, que, entre outros objetivos, visa aumentar a permanência de estudantes no espaço escolar a partir da oferta de atividades educativas no contra turno escolar. As considerações finais apontam que a vinculação da capoeira com a cultura afro-brasileira, por vezes, tem sido rejeitada devido à presença de traços que a conectam com a religiosidade de matriz africana, sobretudo o candomblé e a umbanda. Diante desse contexto, identificamos, nas aulas de capoeira, tentativas de “esportizar” a manifestação como forma de lidar com a intolerância religiosa presente no cotidiano escolar.
LEITURA LITERÁRIA E MEMES: ANÁLISE DE UMA PROPOSTA
Authors: Bordinhão dos Santos Katrym Aline
Published: February 2019

Aliar novas tecnologias ao ensino de literatura esbarra no desafio de não se deixar o texto literário em segundo plano ou apenas mudar o suporte em que ele aparece, sem que haja, de fato, uma preocupação com sua interpretação. Com o objetivo de refletir sobre uma proposta acerca da compreensão de um texto literário, este trabalho apresenta uma experiência realizada em sala de aula com turmas do ensino médio e a leitura dos textos O alienista, de Machado de Assis, e A hora da estrela, de Clarice Lispector, demonstrando uma prática de uso do texto literário vinculada à criação de memes, que também podem ser considerados gêneros textuais. Levando em conta os apontamentos de Rildo Cosson e Jean Foucambert,  discute-se a validade e os resultados da atividade, que aborda um gênero que é de conhecimento dos estudantes e que gera até mesmo estranheza quando é aproximado da prática da aula de literatura. Notadamente se percebeu o interesse de uma parcela dos estudantes, acostumados com o gênero textual, o que culminou na produção de memes que demonstraram um repertório criativo na busca por atingir o sentido que experimentaram nas leituras. Em suma, verificou-se uma apropriação do sentido e das diversas possibilidades de se abordar um fato que pode soar aparentemente sem importância no enredo, mas que, fazendo parte da literatura, permite reflexões sobre o processo de formação humana propiciado por essa tarefa, potencializada pela escola, espaço do qual se espera tal experiência.
O USO DE MEMES NAS AULAS DE HISTÓRIA
Authors: Lamarão Luisa Quarti
Published: February 2019

Os estudantes da chamada geração virtual, conhecidos como “nativos digitais”, apresentam desafios diários às práticas docentes contemporâneas. A constante oferta de informação fora da sala de aula, disponível pela internet, e consequentemente a criação de uma nova forma de linguagem e comunicação entre os alunos, torna importante a discussão sobre novas estratégias em sala de aula. Nesse sentido, o presente trabalho busca relatar uma experiência pedagógica com o uso de memes na elaboração de questões e também na proposta de os próprios alunos criarem seus memes a partir das aulas de História, em turmas de 7º e 9º anos do Ensino Fundamental II. Memes são imagens, frases ou vídeos que se reproduzem rapidamente pela internet dada a mensagem e a linguagem atraentes que exibem. A atividade apresentou resultados interessantes, uma vez que, por um lado, atualizou a apresentação das avaliações, já que oferece uma linguagem semelhante àquela que eles estão acostumados em seu cotidiano fora da escola; por outro, colocou os estudantes como produtores de conhecimento, interpretando os temas históricos com seus “olhos cibernéticos”. A intenção inicial do projeto era fazê-los enxergar que o conhecimento histórico pode ser trabalhado sob diferentes pontos de vista, inclusive na linguagem viral dos memes. Dessa forma, percebe-se a obsolescência da sala de aula focada numa pedagogia da transmissão, que não enxerga o protagonismo dos estudantes no processo de aprendizagem. Reconhecendo a importância da interatividade nos dias de hoje, torna-se fundamental inserir, de maneira responsável, a linguagem da internet no ambiente escolar.
MEMES DE INTERNET E EDUCAÇÃO: UMA SEQUÊNCIA DIDÁTICA PARA AS AULAS DE HISTÓRIA E LÍNGUA PORTUGUESA
Authors: De Souza Maria Alice
Published: February 2019

Um dos desafios da educação contemporânea é promover práticas que oportunizem a participação crítica do educando em atividades próprias da cultura digital. Dessa forma, objetivando, de um lado, legitimar as vivências trazidas pelos aprendizes e, por outro, refletir sobre as características do texto digital, o presente artigo apresenta uma sequência didática desenvolvida com alunos do ensino médio de uma escola pública da rede estadual do município de Belo Horizonte no Estado de Minas Gerais utilizando o meme de internet. Ora, conhecido pela combinação de imagens vinculadas a legendas com teor normalmente irônico ou bem-humorado, o meme de internet tornou-se bem popular entre os jovens, propagando determinada ideia, piada ou comportamento. Mediante revisão bibliográfica, este trabalho apresenta ainda uma visão concisa do meme de internet, considerando sua estrutura, tipos de enunciados, inserção sociocultural e práticas sociais a ele atreladas. Assim, para apresentar a história de constituição social do meme, recorreu-se a Dawkins (1978); Dennett (1998); Blackmore (2002); Recuero (2007); Jenkins (2009); Sales (2010); Souza Junior (2014); Shifman (2014); Barreto (2015); Escalante (2016); Chagas (2016). Com o intuito de situar o uso do meme de acordo com as demandas sociais, o texto apresenta as considerações de Soares (2002); Xavier (2005); Coscarelli (2006); Rojo (2009); Euzébio e Cerutti-Rizzatti (2013); Ribeiro (2017). Ao final da experiência, percebe-se que longe de ser um gênero voltado apenas para a fruição, o meme de internet porta teor crítico, possuindo um grande potencial didático.
NOTAS SOBRE INCLUSÃO DIGITAL NO ESPAÇO ESCOLAR À LUZ DOS USOS DOS MEMES
Authors: Oliveira Ariosvalber De Souza
Published: February 2019

O acesso e domínio das novas tecnologias de informação e comunicação no mundo contemporâneo tornou-se uma exigência importante para o mundo do trabalho. Algo também importante para a melhor sociabilidade e interação do indivíduo com o outro. A questão em destaque também se localiza no mundo educacional, exigindo políticas públicas efetivas por parte do Estado para atender um processo de inclusão digital para os profissionais em educação. Ao mesmo tempo em que as novas linguagens digitais e tecnologias podem ser ferramentas didáticas valiosas para o melhoramento no processo de aprendizagem de alunos e de educadores. Neste contexto, os memes fazem parte do cotidiano das pessoas que utilizam as redes sociais e aplicativos de comunicação, algo muito próximo dos jovens. Seu uso em sala de aula é uma possibilidade de aproximação entre o mundo de expectativa e de interesses de alunos e professores.  Neste sentido, o presente trabalho pretende refletir acerca da problemática da inclusão digital na educação brasileira a partir dos usos de memes, atendendo a duas possibilidades: apresentar apontamentos sobre a exclusão digital no processo educacional brasileiro e indicar o meme como possibilidade de reflexão sobre o cotidiano da sala de aula à luz da exclusão e da inclusão digital.
Meme, educação e interatividade: entrevista com Marco Silva
Authors: Pimentel Mariano
Published: February 2019

Meme, educação e interatividade: entrevista com Marco Silva(por Mariano Pimentel)
A literature review exploring student midwives' experiences of continuity of mentorship on the labour ward
Authors: Hallam Emma , Choucri Lesley
Published: February 2019

Background

Continuity of mentorship is central to students' clinical placement experience. Despite a plethora of studies investigating student-mentor relationships and how it affects grading, limited attention has been paid to the extent to which a lack of continuity of mentorship affects placement experience.

Aims

To explore the importance of mentor continuity on labour ward for pre-registration midwifery students.

Methods

A database search was conducted using the terms: ‘student midwives’, ‘continuity’, ‘mentor’, ‘preceptor’, ‘mentorship’, ‘labour ward’, ‘delivery suite’ and ‘experiences.’

Findings

Continuity of mentorship enhances learning and improves clinical practice experience.

Conclusions

A lack of continuity affects all aspects of student midwives’ experiences of the labour ward. Good mentor practice should focus on continuity and the introduction of co-mentoring, where a student is mentored by at least 2 midwives, in order to reduce the strain on mentors while retaining the feeling of belonging that student midwives value.
Nutrition in senior cats and dogs: how does the diet need to change, when and why?
Authors: Groves Ellie
Published: February 2019

With an ever-growing senior pet population, it is vital that clinicians take a proactive approach to nutritionally assessing these pets and providing optimal recommendations for their life stage, taking into account both the physiological and metabolic changes seen with ageing, and the patient as an individual. The nutritional needs of senior patients can differ significantly compared to other life stages, and an increasing body of research is starting to help us as veterinary surgeons to instigate appropriate dietary changes to maximise longevity and quality of life. Factors requiring consideration include changes in the metabolic energy requirement, protein levels and fat levels in the food. There is a specific focus on minimising sarcopenia — delaying its onset, reducing its progression and minimising its clinical and functional consequences. Other nutrients with varying degrees of evidence for benefits in senior patients include omega-3 fatty acids, medium-chain triglycerides and antioxidants. This article explores some of the latest knowledge on key nutrient requirements of older pets, to assist the clinician to provide more confident advice to owners. It also looks at some of the challenges that can be faced in the senior life stage, as well as how best to approach the nutritional assessment and achieve long-term compliance in order to maximise the chances of a successful outcome.
The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit
Authors: Young Dan F. , Wignall-Fleming Elizabeth B. , Busse David C. , Pickin Matthew J. , Hankinson Jacqueline , Randall Elizabeth M. , Tavendale Amy , Davison Andrew J. , Lamont Douglas , Tregoning John S. , Goodbourn Steve , Randall Richard E.
Published: February 2019

Paramyxoviruses can establish persistent infections both in vitro and in vivo, some of which lead to chronic disease. However, little is known about the molecular events that contribute to the establishment of persistent infections by RNA viruses. Using parainfluenza virus type 5 (PIV5) as a model we show that phosphorylation of the P protein, which is a key component of the viral RNA polymerase complex, determines whether or not viral transcription and replication becomes repressed at late times after infection. If the virus becomes repressed, persistence is established, but if not, the infected cells die. We found that single amino acid changes at various positions within the P protein switched the infection phenotype from lytic to persistent. Lytic variants replicated to higher titres in mice than persistent variants and caused greater infiltration of immune cells into infected lungs but were cleared more rapidly. We propose that during the acute phases of viral infection in vivo, lytic variants of PIV5 will be selected but, as the adaptive immune response develops, variants in which viral replication can be repressed will be selected, leading to the establishment of prolonged, persistent infections. We suggest that similar selection processes may operate for other RNA viruses.
Lesions in endocrine glands as a complication of immunotherapy in the practice of oncologist
Authors: Nuralieva Nurana F. , Troshina Ekaterina A. , Melnichenko Galina A.
Published: February 2019

This review describes the lesions of the endocrine system that occur as a result of immunotherapy of cancer. This phenomenon is associated with the inhibition by monoclonal antibodies of checkpoints, which do not allow the immune system to affect tumor cells: CTLA-4, PD-1 and PD-L1. Immunotherapy by this group of drugs allows to increase the life expectancy of patients with cancer, but it also leads to the development of autoimmune endocrinopathies (thyroiditis, adrenalitis, diabetes mellitus, hypophysitis), which often manifest by life-threatening conditions. In view of the above, the necessity to carry out regular monitoring of the function of target organs in patients receiving immunotherapy for malignant tumors is discussed.
On the other hand, the phenomenon of developing the autoimmune endocrinopathies during therapy with immunological checkpoints inhibitors is of fundamental interest to endocrinologists. Iatrogenic lesions of the endocrine system are unique models of initiation of immune autoagression. Thus, the development of adrenalitis in patients receiving treatment with a PD-1 inhibitor suggests that the PD-1 is involved in the pathogenesis of autoimmune adrenal insufficiency in patients not receiving treatment with this drug. Thus, clarification of the role of PD-1 in the development of adrenalitis is required. The results of such investigations will allow to identify the risk groups for the development of autoimmune adrenal insufficiency and, accordingly, timely diagnosing it and beginning treatment.
Addenda do dziejów oświaty. Z badań nad prasą Drugiej Rzeczypospolitej, red. nauk. Iwonna Michalska i Grzegorz Michalski, Wydawnictwo Uniwersytetu Łódzkiego, Łódź 2013, ss. 348
Authors: Lewicka Magdalena
Published: February 2019

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Eugenia Bernadeta Malewska (1935–2015)
Authors: Radziszewska Maria
Published: February 2019

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Polskie dziedzictwo edukacyjne od XVI do XX wieku – ciągłość i zmiana. Zbiór studiów i rozpraw ofiarowanych Profesorowi Lechowi Mokrzeckiemu z okazji Jubilueszu 80 urodzin, red. R. Grzybowski, K. Jakubiak, M. Brodnicki, T. Maliszewski, Toruń 2015, ss. 637
Authors: Nowicki Michał
Published: February 2019

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Edukacyjna funkcja koroplastycznych przedstawień terakotowych z Egiptu okresu grecko-rzymskiego, na podstawie wybranych grup zabytków
Authors: Jędraszak Sławomir
Published: February 2019

The Educational Function of Terracotta Representations from Egypt in the Graeco-Roman PeriodThe subject of this paper aims to investigate problems associated with selected examples of terracotta drawn from the wide iconographic range of figurines produced in Egypt during the Graeco-Roman period. It attempts to find an answer to the question of whether, in the case of the categories of figurines and terracotta plaques, there are any associations or correlations with upbringing and education. The author maintains that the terracotta figurines, which are the subject of this paper, could include, among many others, examples evoking patterns of appropriate behaviour. Some figurines also played a significant part in the history of Graeco-Roman Egypt, forming an important source for the promotion of a range of information with a socio-political content.
Universal modification of vector weighted method of correlated sampling with finite computational cost
Authors: Medvedev Ilya N.
Published: February 2019

The weighted method of dependent trials or weighted method of correlated sampling (MCS) allows one to construct estimators for functionals based on the same Markov chain simultaneously for a given range of the problem parameters. Choosing an appropriate Markov chain, it is necessary to take into account additional conditions providing the finiteness of the computational cost of weighted MCS. In this paper we study the issue of finite computational cost of the method of correlated sampling (MCS) in application to evaluation of linear functionals of solutions to a set of systems of 2nd kind integral equations. A universal modification of the vector weighted MCS is constructed providing the branching of chain trajectory according to elements of matrix weights. It is proved that the computational cost of the constructed algorithm is bounded in the case the base functionals are also bounded. The results of numerical experiments using the modified weighted estimator are presented for some problems of the theory of radiation transfer subject to polarization.
Acceptability, Feasibility, and Preliminary Efficacy of a Theory-Based Relational Embodied Conversational Agent Mobile Phone Intervention to Promote HIV Medication Adherence in Young HIV-Positive African American MSM
Authors: Dworkin Mark S. , Lee Sangyoon , Chakraborty Apurba , Monahan Colleen , Hightow-Weidman Lisa , Garofalo Robert , Qato Dima M. , Liu Li , Jimenez Antonio
Published: February 2019

An embodied conversational agent can serve as a relational agent and provide information, motivation, and behavioral skills. To evaluate the feasibility, acceptability, and preliminary efficacy of My Personal Health Guide, a theory-based mobile-delivered embodied conversational agent intervention to improve adherence to antiretroviral therapy in young African American men who have sex with men, we conducted this prospective pilot study using a 3-month pre–post design. Outcome measures included adherence, acceptability, feasibility, pre versus post health literacy, and pre versus post self-efficacy. There were 43 participants. Pill count adherence > 80% improved from 62% at baseline to 88% at follow-up (p = .05). The acceptability of the app was high. Feasibility issues identified included loss of usage data from unplanned participant app deletion. Health literacy improved whereas self-efficacy was high at baseline and follow-up. This pilot study of My Personal Health Guide demonstrated acceptability and preliminary efficacy in improving adherence in this important population.
Depression, Social Support, and Adherence to Antiretroviral Therapy Among People Living With HIV in Guangxi, China: A Longitudinal Study
Authors: Mao Yuchen , Qiao Shan , Li Xiaoming , Zhao Qun , Zhou Yuejiao , Shen Zhiyong
Published: February 2019

Depression can result in poor adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV), and social support can help mitigate the negative relationship. However, little is known about how depression and social support synergistically influence ART adherence over time. The current study aims to explore longitudinal associations between them and examine which sources of social support can play a mediating role between depression and ART adherence over time. A randomized controlled clinical trial was conducted between 2013 and 2016 in Guangxi, China. The study sample was composed of 319 PLHIV who were randomized into control condition and provided data at baseline and at least one of the six follow-ups. The results revealed negative associations of depression with ART adherence over time, and a mediating effect of perceived support from spouse/partner or children. Interventions to promote ART adherence should focus on strengthening PLHIV's relationships with their spouse/partner and children, promoting collaborative provider-patient relationships, and enhancing peer support among PLHIV.
Implications for PrEP Uptake in Young Adults Experiencing Homelessness: A Mixed Methods Study
Authors: Santa Maria Diane , Gallardo Kathryn R. , Narendorf Sarah , Petering Robin , Barman-Adhikari Anamika , Flash Charlene , Hsu Hsun-Ta , Shelton Jama , Ferguson Kristin , Bender Kimberly
Published: February 2019

Youth experiencing homelessness (YEH) have a high risk of contracting HIV; however, they remain relatively unreached by pre-exposure prophylaxis (PrEP)-based HIV prevention initiatives. We used a cross-sectional mixed-methods study to explore PrEP knowledge, interest, facilitators, and barriers among YEH. Young adults were recruited from agencies serving YEH in Houston, TX (n = 30) and Los Angeles, CA (n = 15) to participate in an electronic self-report survey and a semistructured interview. Survey results indicate that 68.2% of YEH had low or no prior knowledge of PrEP, though 63.7% reported interest in taking PrEP. Qualitative results revealed facilitators of PrEP use, including high PrEP acceptability and awareness, and supportive social networks. Several barriers emerged, including medication-related barriers, adherence, cost, access barriers, low perceived HIV risk, perceived stigma of PrEP use, and low PrEP awareness. Despite high PrEP acceptability, PrEP use among YEH remains low partly due to low PrEP awareness, low perceived HIV risk, and medical mistrust.
HIV Prevention Practices and Non-Federal Funding Among U.S. States and Non-State Regions: A Survey of HIV/AIDS Directors
Authors: Hattis Ronald P. , Strydom Richel Y. , Gaio Josileide , Stover Deanna C.
Published: February 2019

We surveyed U.S. HIV/AIDS directors or designees in states and non-state regions, regarding factors influencing HIV viral suppression: (1) non-federal prevention funding; (2) contacting newly reported patients and providers, for care linkage and partner services; (3) follow-up of non-received viral load reports, to identify untreated patients; and (4) genotype/phenotype surveillance, to monitor drug resistance. The survey was conducted April–July 2015; 50 (87.7%) participated. Eighty percent of jurisdictions contacted all newly reported patients; 60% contacted all providers. HIV resistance tests were reportable in 38% 66% contacted providers and/or patients about missed viral loads. Non-federal funding was significantly associated with annual diagnoses (p = .0001) and population (p = .0002), but not with other factors studied. Many jurisdictions lacked non-federal funding (28%), or experienced unrestored reductions since 2008 (33%). Jurisdictions’ funding and preventive practices varied greatly. HIV viral suppression could be enhanced by restoring (or establishing) non-federal prevention funding, and by more standardized surveillance/outreach practices.
Razumijevanje motiviranosti značenja frazema u talijanskome kao inome jeziku
Authors: Marković Irena
Published: February 2019

Članak se bavi kognitivno-lingvističkim pristupom frazemima (Broz 2015; Lakoff 1987) u talijanskome kao inome jeziku (Levorato i Cacciari 1992). Istražuje se motiviranost značenja i razumijevanje motiviranosti značenja frazema hrvatskih govornika talijanskoga kao inog jezika. Arbitrarnost jezičnoga znaka pri ovladavanju inim jezikom često dovodi do vrlo niske razine transparentnosti značenja novoučene riječi. U ovladavanju frazemima postoji olakotna okolnost da sličnost (strukturalna i značenjska) u hrvatskome i talijanskome jeziku olakšava njihovu interpretaciju (i razumijevanje njihova metaforičkoga značenja) te samo poznavanje značenja frazema hrvatskoga jezika automatski dovodi do visoke transparentnosti značenja talijanskih frazema (kao i obrnutoga ishoda: negativnoga prijenosa). Uzeli smo u obzir sve varijable koje mogu utjecati na interpretaciju frazema u J2 (Cardona 2008) među studentima inojezičnoga talijanskoga čiji je materinski jezik hrvatski. Preliminarnim ispitivanjem izdvojeni su najpoznatiji frazemi na hrvatskome jeziku (prema mišljenju ispitanika) te paralelno oni talijanski, a zatim su podijeljeni u četiri skupine: a) potpuni hrvatskotalijanski ekvivalenti, b) parcijalni (semantičko-formalni) i različiti talijanski ekvivalenti, c) nepoznati talijanski frazemi (s ekvivalentima i bez ekvivalenata) te d) zastarjeli hrvatski frazemi (kako bi se utvrdila paralela u interpretaciji i motivaciji tih frazema i onih iz treće skupine). Metodologija iz Levorato i Cacciari (1992) zapravo je prilagođena našemu istraživanju, gdje se osim poznatosti i transparentnosti značenja tražila i (ne)podudarnost s hrvatskim frazemima i na osnovi te selekcije odvojeno prezentirala ispitanicima.
Književno oblikovanje gospodarskih problema u romanu Tijesna zemlja Mate Balote
Authors: Franković Sanja
Published: February 2019

Gospodarski problemi Balotina romana Tijesna zemlja sastavni su dio života u piščevu rodnom selu u posljednjim desetljećima 19. stoljeća, kada naturalna razmjena ustupa mjesto novčanom gospodarstvu. Motivi zemlje, vinove loze i maslina nisu samo simboli preživljavanja nego i trajnosti obiteljskih naraštaja. Pojedinac odrastao u tradiciji poistovjećuje svoj bitak s radom na zemlji – škrtoj, ali jedinoj sigurnoj imovini. Međutim, zemlja sa zasnivanjem novih obitelji postaje sve manja, stoga se zemljoradnja dopunjava drugim, u očima seljana manje uglednim poslovima: lončarstvom, pomorstvom i trgovinom. Polazeći od stava da roman nije prozna ilustracija piščevih znanstvenih ideja, nego umjetnički tekst, rad razmatra pripovjedne tehnike u književnome oblikovanju gospodarskih problema: liriziran pripovijedani monolog odraslih likova o svojim planovima preživljavanja ili obogaćivanja; pripovjedačevu psihonaraciju s dječjim fokalizatorom o pučkim vjerovanjima i seljačkome načinu rada i života; kontrastivnu karakterizaciju likova kao primjer suprotna stava prema radu i stjecanju bogatstva; pripovjedačeve komentare o povijesti rakljanskih doseljenika i o negativnim utjecajima novca na individualnu i seosku kolektivnu etiku; opise prirode kao izvora života te dijaloge kao pokazatelje međuljudskih odnosa i načina života.
Paljetkova lutkarska dramaturgija
Authors: Vigato Teodora
Published: February 2019

Luko Paljetak od 1968. do 1978. radio je u Kazalištu lutaka Zadar kao glumac, dramaturg i redatelj te je usmjerio zadarsko/ hrvatsko lutkarstvo prema modernome izrazu. U povijesti lutkarstva prvenstveno je poznat kao redatelj. Međutim, u ovome se radu autorica bavi njegovim dramskim tekstovima koji su manje poznati. U arhivu Kazališta lutaka Zadar pronađen je tekst S one strane ogledala omnibus šest priča za fluorescentni teatar koji nije postavljen na scenu, a autorica upravo na tome tekstu iščitava znakove rane postmoderne: udaljavanje od didaktičkoga sadržaja, odbacivanje paravana, kritiku sustava, odgode značenja, raspitivanje o novim predodžbama. Antibajku Bajka o kraljevim trešnjama i humornu fantaziju Duhovi s planeta Strahurn kritika nije dobro ocijenila, dok je tekst Nikola Tesla: priče iz djetinjasta bio literarni predložak za zanimljivu predstavu koja se izvodila samo u Zadru. Paljetak koristi antropomorfizaciju kako bi kazao nešto smiješno o ljudima, kako u poznatoj zbirci pjesama Miševi i mačke naglavačke tako i u svojim dramskim tekstovima koje je namijenio za lutkarska, ali i nelutkarska uprizorenja.
Vile doline Neretve: poetički i motivski markeri usmenih predaja o vilama na primjeru prikupljenih usmenih predaja u dolini Neretve
Authors: Vekić Denis
Published: February 2019

Rad proučava i analizira usmene predaje o vilama koje su prikupljene u dolini Neretve. Ističu se pojedini poetički i motivski markeri proučavanih usmenih predaja. Autor se služi predajama koje su do sada prikupili etnolozi, ali i predajama prikupljenim vlastitim terenskim istraživanjem. Opisi vila u usmenim predajama koje se pripovijedaju u neretvanskoj dolini variraju te se tako prenose priče o vilama ljudskoga tijela i ljudskih dimenzija, ali postoje također predaje o vilama s animalnim obilježjima. Rad proučava simboličku ulogu viline kose u predajama kao i simboličku, kultnu i mitsku predodžbu špilja u svezi s vilama.
Zbornik u čast Mariji Turk
Authors: Zubčić Sanja
Published: February 2019

Od fonologije do leksikologije. Zbornik u čast Mariji Turk, ur. Diana Stolac, Rijeka: Filozofski fakultet u Rijeci, 2018.
Smjerokaz novim čitanjima - izabrana djela "posljednjega ilirca" hrvatske književnosti
Authors: Kuvač-Levačić Kornelija
Published: February 2019

Ivan Trnski, Izabrana djela, Zagreb: Matica hrvatska, 2017.
Прочтение Моретти
Authors: B. Орехов Борис
Published: February 2019

Моретти Ф. 2016. Дальнее чтение, Пер. с англ. А. Вдовина, О. Собчука, А. Шели. Науч. ред. перевода И. Кушнарева, Москва: Изд-во Института Гайдара, 352 с.
Analisis Kriteria untuk Perencanaan Program Pemeliharaan Embung Irigasi (Studi Kasus : Embung Haliwen dan Haekrit Kabupaten Belu)
Authors: Bria Melchior
Published: February 2019

: The problem of irrigation dams (small farm reservoair) is functional degradation, characterized by reduced capacity of collected water, sedimentation, seepage, the growth of wild plants in the body of weir / dike, erosion, and some other problems. Therefore, good and sustainable maintenance is required. One of them by determining the right criteria as the basis for planning the maintenance program. The determination of this criterion is based on fact (filling questionnaire) and literature review which then tested the validity and reliability to determine the criteria to be used. Furthermore, the analysis of the various criteria stated valid and reliable. Criteria are determined based on validity, reliability and frequency distribution with the number of procession answers is very important and important> 50%. The results of the analysis indicate influential Criteria and subcriteria namely Structural Stability Criteria (sub criteria: Body Dam, Embung Pool, Spillway, Building Assistance, Water Distribution Network, Condition Value); Physical and Environmental Criteria (subcriteria of Changes in the Natural Span, Rainfall and Evapotranspiration, Soil Structure around Embung, Plague of Plague Around Embung); Financial Criteria / Eknomi (subcriteria of Agricultural Product Result, Economic Value of Emung, Investment Fund); Government Policy Criteria (subcriteria: Spatial Plan, Provision of Maintenance Budget, Water Management, Institutional / Organization Aspect); Socio-Cultural Criteria (subcriteria: Community Participation, Local Wisdom / Customary Law, and Tourism Development)
Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation
Authors: Kiff Sarah , Babb Carolyn , Guemes Maria , Dastamani Antonia , Gilbert Clare , Flanagan Sarah E , Ellard Sian , Barton John , Dattani M , Shah Pratik
Published: February 2019

We report a case of partial diazoxide responsiveness in a child with severe congenital hyperinsulinaemic hypoglycaemia (CHI) due to a homozygous ABCC8 mutation. A term baby, with birth weight 3.8 kg, born to consanguineous parents presented on day 1 of life with hypoglycaemia. Hypoglycaemia screen confirmed CHI. Diazoxide was commenced on day 7 due to ongoing elevated glucose requirements (15 mg/kg/min), but despite escalation to a maximum dose (15 mg/kg/day), intravenous (i.v.) glucose requirement remained high (13 mg/kg/min). Genetic testing demonstrated a homozygous ABCC8 splicing mutation (c.2041-1G>C), consistent with a diffuse form of CHI. Diazoxide treatment was therefore stopped and subcutaneous (s.c.) octreotide infusion commenced. Despite this, s.c. glucagon and i.v. glucose were required to prevent hypoglycaemia. A trial of sirolimus and near-total pancreatectomy were considered, however due to the significant morbidity potentially associated with these, a further trial of diazoxide was commenced at 1.5 months of age. At a dose of 10 mg/kg/day of diazoxide and 40 µg/kg/day of octreotide, both i.v. glucose and s.c. glucagon were stopped as normoglycaemia was achieved. CHI due to homozygous ABCC8 mutation poses management difficulties if the somatostatin analogue octreotide is insufficient to prevent hypoglycaemia. Diazoxide unresponsiveness is often thought to be a hallmark of recessively inherited ABCC8 mutations. This patient was initially thought to be non-responsive, but this case highlights that a further trial of diazoxide is warranted, where other available treatments are associated with significant risk of morbidity.

Learning points:

Homozygous ABCC8 mutations are commonly thought to cause diazoxide non-responsive hyperinsulinaemic hypoglycaemia.

This case highlights that partial diazoxide responsiveness in homozygous ABCC8 mutations may be present.

Trial of diazoxide treatment in combination with octreotide is warranted prior to considering alternative treatments, such as sirolimus or near-total pancreatectomy, which are associated with more significant side effects.
Genetics of aldosterone-producing adenomas with pathogenic KCNJ5 variants
Authors: Lerario Antonio M , Nanba Kazutaka , Blinder Amy R , Suematsu Sachiko , Omura Masao , Nishikawa Tetsuo , Giordano Thomas J , Rainey William E , Else Tobias
Published: February 2019

Somatic variants in genes that regulate intracellular ion homeostasis have been identified in aldosterone-producing adenomas (APAs). Although the mechanisms leading to increased aldosterone production in APA cells have been well studied, the molecular events that cause cell proliferation and tumor formation are poorly understood. In the present study, we have performed whole-exome sequencing (WES) to characterize the landscape of somatic alterations in a homogeneous series of APA with pathogenic KCNJ5 variants. In the WES analysis on 11 APAs, 84 exonic somatic events were called by 3 different somatic callers. Besides the KCNJ5 gene, only two genes (MED13 and ZNF669) harbored somatic variants in more than one APA. Unlike adrenocortical carcinomas, no chromosomal instability was observed by the somatic copy-number alteration and loss of heterozygosity analyses. The estimated tumor purity ranged from 0.35 to 0.67, suggesting a significant proportion of normal cell infiltration. Based on the results of PureCN analysis, the KCNJ5 variants appear to be clonal. In conclusion, in addition to KCNJ5 somatic pathogenic variants, no significant somatic event that would obviously explain proliferation or tumor growth was observed in our homogeneous cohort of KCNJ5-mutated APA. The molecular mechanisms causing APA growth and tumorigenesis remain to be elucidated.
Factores competitivos para el desarrollo de la caficultura peruana
Authors: Nahuamel Jacinto Edwin
Published: February 2019

La presente investigación realiza una identificación y evaluación de los factores competitivos de la caficultura peruana. Para lo cual se ha elaborado una tabla ordenando los factores competitivos de la cadena productiva del café, y analizando las condiciones naturales que son favorables para su producción, asimismo se ha identificado las condiciones sociales y económicas que coadyuvan en la competitividad, calificando de en una puntuación de uno (1) a diez (10). Como resultado se evaluó los factores competitivos y se presenta de la siguiente manera: condiciones agroecológicas apropiadas y calidad en taza fueron calificados con puntajes altos de 10 y 8 respectivamente; los demás factores competitivos y sus respectivas calificaciones son tecnología de producción, desempeño económico y mercado laboral cuya calificación es seis (6); vías de comunicación y calidad de vida de los caficultores con calificación de cinco (5) e institucionalidad cafetalera calificado con un valor de cuatro (4).
Esquemas mentales desadaptativos según la composición familiar en adolescentes arequipeños de escuelas públicas
Authors: Seperak Viera Rosa Angélica , Díaz Huayna Luz Marina , Canazas Bustios María Daniela , Shelach Bellido Salomón
Published: February 2019

El impacto de la familia en el desarrollo del individuo ha sido objeto de muchas investigaciones, más aún por la variabilidad estructural en la que se encuentra inmersa y que ha cobrado protagonismo en el análisis de la salud psicológica de los miembros que la componen. El presente estudio tuvo como objetivo realizar un análisis de los esquemas mentales desadaptativos según el tipo de estructura familiar de adolescentes de 13 escuelas públicas de Arequipa Metropolitana. Se utilizó como instrumento el Cuestionario de Esquemas de Young (YSQ-L2) el cual fue validado en Perú por León y Sucari (2012). Los hallazgos demuestran que existen diferencias entre los hogares reconstruidos y las demás estructuras en cuanto a la presencia de los esquemas mentales desadpatativos de privación emocional, desconfianza, hipercritinismo y grandiosidad.
Katrin Fischer. Yakṣagāna. Eine Einführung in eine südindische Theatertradition Mit übersetzung und Text von „Abhimanyu Kāḷaga“
Authors: Śliwczyńska Bożena
Published: February 2019

Warsaw University
Guy L. Beck (ed.). Alternative Krishnas. Regional and Vernacular Variations on a Hindu Deity
Authors: Śliwczyńska Bożena
Published: February 2019

Warsaw University
Moral norms and physical necessity: Zhu Xi on the concept of Li
Authors: Yuksel Diana
Published: February 2019

University of BucharestThe aim of this paper is to analyze one of the key concepts in Zhu Xi’s thought，Li 理，from the perspective of Confucian ethics and to stress its importance in the strategic synthesis of Confucian thought realized by Zhu Xi in the 12th century. Focusing on the fundamental concepts of Neo-Confucian thought—Li (principle), Qi 氣 (vital force), Dao 道 (the way/nature), Ren 仁 (humanity) and Xin 心 (mind-heart)—the paper turns its attention to the inseparability of metaphysical and ontological perspectives on the one hand, and, on the other hand, the ethical perspective in the new Confucian paradigm. Taking into consideration the various definitions given to the concept Li, this paper attempts an interpretation of the concept based on the ineluctability of the Confucian moral norms stated by Zhu Xi, according to which in the order of the world everything happens under the unavoidable sign of the necessity of its issuance. These findings suggest that Li is a concept composed of a sum of various aspects (li) resulting from the different instances of its issuance in the world with which the mind-heart governed by it is confronted, therefore proving that Li is the sum of moral norms that encompass humanity, righteousness, rites and wisdom, the pillars of the Confucian moral order.
Travel records (游记 youji) for gardens as source for researching officials’ private lives in 11th-century China
Authors: Stepanova Jekaterina
Published: February 2019

The Baltic International AcademyThis article deals with the 11th century travel records (youji) for the gardens in Luoyang. These texts were usually ordered by owners of gardens and were written by famous authors. According to youji materials, a Chinese garden can be presented as a part of nature, a source of pleasure, or a shelter for a hermit, so the article is divided into these three parts. Through the descriptions of gardens in youji, not only the craft of gardening, but also the way of life and private life of garden owners can be examined.
Introduction: Exploring the human in traditional China
Authors: Poškaitė Loreta
Published: February 2019

The papers of this issue were first presented at the international interdisciplinary seminar in sinology, Human in the Sciences of Traditional and Contemporary China, which was held on 4–5 October 2007 at the Vilnius University Centre of Oriental Studies. The original intention of the organizers of the seminar was to gather for the first time in Lithuania sinologists from various countries, East and West, for discussion about various aspects and perspectives of human beings as they were investigated in the sciences of traditional and contemporary China.