bluuebunny/crossref_metadata_2025 huggingface dataset:
Selected tumour biomarker levels in sheep with pulmonary adenomatosis
Authors: Özkan Cumali , Yıldırım Serkan , Huyut Zübeyir , Özbek Mustafa
Published: March 2020

Introduction

Sheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the Jaagsiekte sheep retrovirus. Since effective treatment and a vaccination procedure are not currently possible, control and eradication of the disease is difficult. It leads to serious economic losses around the world, therefore studies are currently underway in order to design control and eradication programmes. In this study, levels and changes in selected tumour markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA 19-9, CA 15-3, and alphafetoprotein (AFP)-3) and their diagnostic significance were investigated.

Material and Methods

A total of 30 sheep were used. Clinical examinations were performed and blood samples were obtained before slaughter from all animals with presumed OPA. Blood samples with positive OPA results by macroscopic and histopathological examination were included in the study as the experimental group and numbered 20. Sheep totalling 10 had negative OPA results and provided control samples.

Results

CEA levels were similar in both groups, and the differences were statistically insignificant (P > 0.05). CA 125, CA 19-9, CA 15-3, and AFP-3 levels were higher in the OPA group than the control group and with statistical significance (P < 0.05). In all OPA animals, CA 125 levels were higher than 1 U/mL.

Conclusion

serum CAs and AFP levels increase significantly in adenomatous sheep. These tumour markers are thought to facilitate the diagnosis of OPA.
Epizootic situation of feline Bartonella infection in eastern Poland
Authors: Mazurek Łukasz , Carbonero Alfonso , Skrzypczak Maciej , Winiarczyk Stanisław , Adaszek Łukasz
Published: March 2020

Introduction

The aim of the study was to establish the prevalence of Bartonella spp. in cats in eastern Poland, and to determine the factors associated with the infection.

Material and Methods

PCRs were performed to detect Bartonella DNA in the whole blood of 672 cats from four regions in eastern Poland (the Lublin, Podlasie, Masovian, and Subcarpathian provinces). The association between the previously selected variables and the dependent variable (presence of Bartonella DNA) was investigated using a logistic regression model.

Results

The overall prevalence of infection was 40.48%. All PCR positive cats were infected with B. henselae. The living conditions of the animals (free outdoor roaming), mixed breed cats, Subcarpathian region, and absence of tick control were significant risk factors associated with Bartonella infection at a 95% confidence level.

Conclusion

Cats in eastern Poland appear to be at risk of a bartonellosis epizootic. Factors which seem to impact the likelihood of infection in cats and factors which seem not to impact it have been suggested. We advocate additional research into the ways bartonellosis spreads, its geographical scope, and the factors that favour its development.
The Changing Digital Culture and its Impact on Women
Authors: Sharma Sunita Ramesh
Published: March 2020

Information and Communication Technologies (ICTs), including the Internet, are increasingly influential across all aspects of life. Women’s Equality is one of the 17 Sustainable Development Goals, but also integral to all dimensions of Inclusive and Sustainable Development.

E-Commerce also known as internet commerce, refers to the buying and selling of goods and services using the internet. The companies of the future, through the rules of electronic commerce, form a new productive framework. These digital transformations have managed to generate new labour paradigms. The paper lists the new jobs profile created by technology. It attempts to find answers to, whether the women are going to benefit from the changes that take place in the labour market and in the economy in general? And is there a new window of opportunity? Or is it simply more of the same? It concludes by giving suggestions, so that the ladder of women development is not thrown away.

Keywords: Internet and gender, Labour paradigms, Algorithms and gender.
THE EFFECT OF OUTLINE PLANNING IN ARGUMENTATIVE ESSAY WRITING OF FOURTH SEMESTER STUDENTS OF ENGLISH DEPARTMENT, FACULTY OF ARTS, UDAYANA UNIVERSITY
Authors: Indriani Ketut Santi
Published: March 2020

This study is aimed to identify the effect of outline planning in argumentative essay writing of fourth semester students of English Department, Faculty of Arts, Udayana University.  Outlining is making a plan to map your writing which shows the content and the sequence of each paragraph in your writing. Task planning will give the students an opportunity to plan what to say and how to write their ideas in the task performance. Task planning can be in the form of cubing, clustering, mapping (Ojima, 2006:566), and outlining (Kellog, 1990: 328). The data source of this study are argumentative essay writing of 30 students. The data in this study was analysed both qualitatively and quantitatively. The data analysis was done by comparing the results of the pre-test and post-test in argumentative essays writing. Pre-test was conducted without outlining the writing while post-test proceeded by outlining the writing. Based on the data analysis, the results shows that there is a significant improvement in students writing after the implementation of the outline planning. The improvement reflected from the reduction of the types and the number of mistake made by the students in their writing.
THE IMPACT OF TECHNOLOGY HELLO ENGLISH APPLICATION IN EFL CLASSROOM
Authors: Butarbutar Ranta , Simatupang Elia
Published: March 2020

Teacing English as foreign language in junior hogh school forced teacher to used to technology as an interest media to attract student in learning. Chiefly, An application was blasted off by CultureAlley in 2014; hello English has potential to solve student’s problem of understanding simple past tense. To seeing  the using Hello English Aplication giving impact significantly in understanding of simple past tense was the crucial intention of this study. In doing treatment, it used experimental and control class with 46 participants. Crucially, study proven that Data findings and discussion proven 1) there was difference significantly of posttest  between at experiemental class; 95.6% and control class; 60.9% 2) Normality distribution figured out experimental group in posttest is 0.200> ? (0.05) and the significance value of control group in posttest is 0.051>? (0.05). The significance value of both groups are higher than ? (0.05). It means that H0 is accepted and H1 is refused. So, the test distribution of both two groups is normal 3) Homogenity test confirmed ? value (significant value) is higher than ? value. ? > ?, 0,955 > 0,05. Back to the hypothesis, H? is accepted if ? > ?. So it means that the classes are homogeny 4) T-Test  delighted  0.000 < a (0.05) for this reason H0 is rejected and H1 is accepted. Absolutely this study concludes the using hello English Aplication is an interest effective media in learning simple past tense; encouraging self-learning; gadget’s changing better behaviour.

 

Keywords: impact, hello english aplication, simple past tense
An AN INVESTIGATION ON THE INDONESIAN CULTURAL ASPECTS IN ENGLISH TEXTBOOKS FOR SENIOR HIGH SCHOOLPUBLISHED BY KEMENDIKBUD
Authors: Syam Samsudin
Published: March 2020

Abstract

Cultural understanding is the core of language acquisition because language and culture can not be seperated with language. Culture can be understand through media either electronic or manual such internet, magazine, textbooks etc. Textbook is one of the media used most people in school. In textbooks, there are many cultural aspects presented for students. Therefore, this study aimed at presenting the cultural aspects, describing the frequency of cultural aspects and Indonesian cultural aspects in English textbooks of  2013 curriculum and describing the level of quality of English textbooks in terms of intercultural awareness.

This study employed a qualitative research design. The data are the cultural aspects and Indonesian cultural aspects in English textbooks of 2013 curriculum grade X, XI and XII. The textbook of these grades has not analyzed by the other researchers. The results show that English textbooks grade X, XI and XII contained 490 cultural aspects consisting of 232 products, 75 practices, 11 perspectives and 172 persons (Yuen:2001).While Indonesian cultural aspects contained 127 consisting of 64 cultural aspects on grade X, 34 on grade XI, and 29 on grade XII.

From the results of the study, it can be concluded that the presentation of cultural aspects and Indonesian cultural aspects are not balanced and does not provide student to have intercultural awareness. And third English textbooks are equality to use in terms of basic cultural awareness. Whereas, advanced cultural awareness and  intercultural awareness leveldo not support students to have intercultural awareness. From the results above the authors of English textbooks should put the more cultural information explicitly Indonesian cultural aspects to enrich students cultural information.

 

Keyword: Indonesian Cultural Aspects, English Textbooks, Kemendikbud
FILIPPO GRANDI REPORTS ON ROHINGYA REFUGEE CRISIS IN BANGLADESH
Authors: DINAMIKA SORAYA GRABIELLA
Published: March 2020

This study concerns with the use of Appraisal Theory developed by Martin & White (2005), under subsumed of engagement system domain. The engagement system deals with dialogic perspective between speakers and listeners, which is influenced by the approach of Bakhtin/ Voloshinov, called heteroglossia. Heteroglossic backdrop reveals the proposition lies behind what is stated. In this study, a verbal interaction between speaker and listener is presented in the form of press conference release. Currently serving Head Commissioner of United Nations High Commissioner for Refugees (UNHCR), Filippo Grandi, held a press conference release containing of his visiting report to the camp shelter of Rohingya refugee in Bangladesh. The press conference release is a recorded-video type one, which has approximately 27:30” in length. It is led by a moderator, reported by the Head Commissioner and joined by 6 follow-up questions. Regarding to engagement system used, the utterances are then transcribed into a transcript, thus it gains approximately 395 clauses, moreover, only the utterances spoken by the Head Commissioner taken as the engagement locution realizations. The objectives of this research fall into three: a) to find out the most predominant heteroglossic backdrop Grandi encodes; b) to recognize the values and viewpoint Grandi intends to convey in his report; and c) to identify the authorial voice Grandi uses in addressing his beliefs of the Rohingya refugee crisis to the audiences. The qualitative descriptive method is applied. It is found that contract-disclaim-counter dominates the report by accounts of 55 realizations. It implies that the facts, Grandi reports may against audiences’ expectation, yet in another clause, he describes the situation which can reform audiences’ different viewpoints toward the crisis.

Keywords: Appraisal Theory, Engagement System, Rohingya Crisis, UNHCR, Filippo Grandi
Improving Grammar Mastery through Movie Segment for the Fourth Semester of English Students academic year 2018/2019 at Madura Islamic University
Authors: Setiyawan Arisandi
Published: March 2020

Grammar learning in the class is not delivered attractively so that it can cause students to have low enthusiasm for learning. Besides, monotonous learning makes students easily get bored. After understanding the importance of grammar in learning English, it is needed to have learning media that can solve students' problems in class. Researchers offer instructional media in the form of authentic material that is a movie segment to be applied in learning grammar. The purpose of this research is to find out how the movie segment can improve the grammar mastery of fourth-semester students. The use of authentic material in the classroom can create a pleasant atmosphere because it can reduce anxiety levels and provide examples of English applications in the real world. Movie Segment is one type of authentic material in the form of video clips that are used to teach grammar. It is also equipped with worksheets, exercises, and answer keys so that it can facilitate the teacher to use the appropriate material and create a pleasant atmosphere in the classroom. The research design used is Classroom Action Research. Meanwhile, The criterion for success in this study is 75% of students achieve 75 in learning Grammar (Simple Past tense). The results of this study indicate that the mean value on the pre-test was 65.2 and the average value of the post-test in cycle 1 increased to 72.8. Then, the post-test mean score in cycle 2 increased to 78.8. The percentage of students who reached above or equal to KKM is 75 increased from 32% to 60% in cycle 1 and 80% in cycle 2. Therefore, this study proves that the use of movie segments can improve grammar understanding and can be used as one of alternative techniques in teaching grammar (past tense).
THE RELATIONSHIP BETWEEN LANGUAGE LEARNING STRATEGIES AND VOCATIONAL LEARNERS’ EFL PROFICIENCY
Authors: Yustitiasari Hilda _
Published: March 2020

Abstract

Language learning strategies (LLS) are perceived as tools for teacher to educate the learners behave self-directed learning. It also known, improving language proficient. In the case of vocational college students, they practically use self-directed learning in learning English outside classroom since they should pass the TOEFL test after the internship as the requirement of graduation. Hereby, this study identifies: (1) the frequently language learning strategy used by vocational college learners, (2) the relationship between language learning strategy and English proficiency, (3) the strategy used by learners which could predict learners proficient. The participant is 52 students of Politeknik Kota Malang in 2016- 2017 academic year which done the TOEFL test and willing to complete the Strategy Inventory of Language Learning (SILL). This study employed quantitative approach and correlational research as the research design to identify the relationship between variables. There are six strategies of language learning strategies by Oxford (1990) as the independent variables (predictors) and English proficiency (criterion) as the dependent variable. Therefore, multiple regression analysis employed in this study. The result showed that metacognitive strategy reported highly used by learners. While compensation, cognitive, social strategies reported medium used by learners. The low strategy used was affective and memory strategies. Although, language learning strategy cannot simultaneously predict the English proficiency there is one strategy that can be used to predict English proficiency, namely compensation strategy.

Keywords: Language Learning Strategies, EFL Learners, English Proficiency.
ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) IN ROBIN ROE’S NOVEL A LIST OF CAGES
Authors: Butar-Butar Vivi Marianti
Published: March 2020

This thesis entitled "Attention Deficit Hyperactivity Disorder (ADHD) in Robin Roe's Novel A List of Cages". This thesis discussed about the symptoms Attention Deficit Hyperactivity Disorder (ADHD) in the novel A List of Cages by Robin Roe. This thesis aimed to find out how the symptoms of ADHD are described through the leading character in the novel. This thesis used to describe the core symptoms of ADHD, namely: Attention, Impulsivity, and Hyperactivity. There are symptoms of ADHD that Adam has, namely: Attention symptom is easily bored; Impulsivity symptom is agitated; and the Hyperactivity symptom is: do excessive motor activities. This thesis used Russell Barkley's theory to analyze the symptoms in a novel using Literary Psychology. In analyzing this thesis, the writer used a qualitative descriptive method that presents all data in the form of words and sentences and uses library research as a way to collect data by reading and selecting quotations from the novel A List of Cages. From this research it is found that the leading character in the novel experienced all the three core symptoms of ADHD.
Pengaruh Pelatihan dan Motivasi Kerja Terhadap Kinerja Kerja Karyawan PT Asia Multidana di Jakarta
Authors: Pratama Okky
Published: March 2020

This study was to detect the effect of training and motivation on employee performance studies in the limited partnership. This research was conducted with survey method and performed in 40 employees of PT Asia Multidana. The sampling technique used random sampling and testing techniques of data used in this study include tests of validity by factor analysis, reliability tests with Cronbach alpha, classical assumption test, multiple linear regression analysis, t test to test and prove the hypothesis of the study. The data collected is tested for validity by factor analysis method and tested reliability with an alpha coefficient (Cronbach alpha), which is the result of all the data is valid and reliable. The results of the analysis and discussion show that: (1) training positively affect the performance of employees, (2) positive motivation does not affect the performance of the employee.
Pengaruh Aktivitas, Solvabilitas dan Ukuran Perusahaan Terhadap Profitabilitas Perusahaan Manufaktur Sub Sektor Makanan dan Minuman di Bursa Efek Indonesia Tahun 2012 – 2017
Authors: Gunawan Hendry
Published: March 2020

The purpose of this research is to determine the effect of the ratio of activity, solvability, firm size to company’s profitability in manufacturing companies food and beverages sub-sector listed in Indonesia Stock Exchange period 2012-2017. The sampling method is done by using purposive sampling. The method of collecting secondary data is taken from the IDX that publishes the financial statements. This research uses descriptive statistical analysis and multiple regression analysis with Eviews 9. The results showed that total asset turnover is positive significant, debt to equity ratio is not significant and firm size is not significant to profitability of company. F-test results show total asset turnover, debt equity ratio and size independent variables in this research simultaneously don’t have a significant effect on the return of equity of companies in the food and beverages sub-sector listed on the Indonesia Stock Exchange.
Interwar period records from the Archive of the Cracow Saltworks Museum in Wieliczka as a source for linguistic studies
Authors: Horyń Ewa
Published: March 2020

Artykuł przedstawia nieopublikowane dotychczas dzieła rękopiśmienne zgromadzone w Archiwum Muzeum Żup Krakowskich Wieliczka, powstałe w okresie dwudziestolecia mię- dzywojennego. Teksty te stanowią cenny i interesujący materiał dla analiz językoznawczych, poszerzają bowiem zasób naszej wiedzy o nowszą warstwę słownictwa zawodowego z zakre- su górnictwa solnego w Polsce, której brak we wcześniejszych opracowaniach tekstowych. Na akta międzywojenne składają się m.in. księgi rachunków solnych, księgi sprzedaży soli, księgi magazynowania soli, zestawienia tygodniowe itp., a także plan ruchu żupy solnej w Wieliczce z 1939 r., publikacja z 1932 r., która zachowała się jedynie w postaci maszynopisu, autorstwa Antoniego Müllera – byłego dyrektora kopalni wielickiej.
Czy zbiór polskich frazeologizmów pochodzenia biblijnego jest zbiorem zamkniętym?
Authors: Koziara Stanisław
Published: March 2020

The paper is dedicated to some selected units of biblical origin in the Polish language, namely fixed word combinations (idiomatic expressions). The author is trying to answer the question whether the collection of such units has the qualities of a closed set, or demonstrates a contemporary tendency to multiply its resources. What is essential for this description is the division into primary and secondary units of biblical origin. Apart from historical data and conditions, which are linked with this issue of Polish phraseology, the paper also contains several examples of the processes, as a result of which the language acquired new phrases of biblical origin.
Wokół frazeologizmu zamienić się w słup soli
Authors: Horyń Ewa
Published: March 2020

This paper is dedicated to the description of the idiomatic expression zamienić się w słup soli in contemporary Polish. First of all, the origin of this word combination was presented, and next – its lexicographic condition. Moreover, phraseological modifications were discussed (exchange, development, shortening and regulation), which a given idiomatic expression undergoes. Linguistic material was excerpted from the National Corpus of Polish and Internet sites.
Evaluation on the Stability of Amine-Mesoporous Silica Adsorbents used for CO2 Capture
Authors: Viet Quang Dang , Duong Dao Van , Hong Ha Vu Thi , Duc Dao Sy , Ngoc Dung Tran Thi , Abu-Zahra Mohammad R.M.
Published: March 2020

Amine-mesoporous silica has been considered as a promising CO2 adsorbent with high potential for the reduction of energy consumption and CO2 capture cost; however, its stability could greatly vary with synthetic method. In this study, adsorbents prepared by impregnating different amines including polyethylenimine (PEI) and 3-aminopropyltriethoxysilane (APTES) onto mesoporous silica were used to evaluate the effect of amines selection on the stability of adsorbents used in CO2 capture process. Results revealed that APTES impregnated mesoporous silica (APTES-MPS) is more stable than PEI-impregnated mesoporous silica (PEI-MPS); APTES-MPS was thermally decomposed at ≈280 oC, while PEI-MPS was thermally decomposed at ≈180 oC only. PEI-MPS was particularly less stable when operating under dry condition; its CO2 adsorption capacity reduced by 22.1% after 10 adsorption/regeneration cycles, however, the capacity can be significantly improved in humid condition. APTES-MPS showed a greater stability with no significant reduction in CO2 capture capacity after 10 adsorption/regeneration cycles. In general, APTES-MPS adsorbent possesses a higher stability compared to PEI-MPS thanks to the formation of chemical bonds between amino-functional groups and mesoporous silica substrate.

Keywords: Mesoporous silica; CO2 capture; Adsorption; Regeneration; Emission.
Dermatologists' Management Approach to Sexually Transmitted Disease
Authors: Rosen Ted
Published: March 2020

Abstract not available.
Dysmorphic Trichophyton rubrum Mimicking Blastomycosis
Authors: Hope Landon , Ibad Sidra , Marks Etan , Hope Richard , Cockerell Clay
Published: March 2020

We will describe a 62 year old immunocompromised, diabetic, male patient who presented with several cutaneous lesions. The patient was 4 years post-nephrectomy due to renal cell carcinoma and 6 months post-renal transplantation at time of presentation. Initial clinical impression was thought to be deep fungal infection or metastatic carcinoma. Trichophyton rubrum with a dysmorphic morphology simulating blastomycosis was ultimately diagnosed.
Dermatitis Artefacta Resembling Pyoderma Gangrenosum
Authors: Michael Mary , Newman Andrew , Barr Jason , Lam Travis
Published: March 2020

Dermatitis artefacta is a self-inflicted skin condition that clinically mimics other dermatologic conditions. The etiology is multifactorial and is linked to underlying psychological conditions or psychosocial stressors with relief from automutilation. Lesions present with variable morphology depending on the type of self-harm and therefore, is a diagnosis of exclusion. We present a case of lesions that initially appeared to be pyoderma gangrenosum due to a similar presentation of nonspecific ulcers on the lower extremity. An important clue to the diagnose of dermatitis artefacta are skin lesions that do not fit a particular histopathological category. Lesions will also be resistant to conventional treatment. Once other dermatologic conditions are ruled out, it is important to consider dermatitis artefacta since early intervention is necessary for good patient outcomes.
Generalized Lichen Nitidus in a Middle-Aged Adult
Authors: LaCour Matthew , Croley Julie Amthor , Wilson Janice
Published: March 2020

Lichen nitidus (LN) is a benign micropapular eruption of unknown etiology that often follows an unpredictable course. LN typically affects children and young adults and presents with asymptomatic, discrete, uniform, skin colored, pin-point sized papules.1 These papules are commonly found on the chest, abdomen, flexor surfaces of the upper extremities, dorsal hand, and anogenital region.1 Focal presentation is more common while generalized distribution of LN is rarer and seen more exclusively in pediatric patients.2 Although patients are typically asymptomatic, pruritus is sometimes a noted symptom.1 We report the diagnosis and treatment of an uncommon case of generalized LN in a middle-aged adult.
Granulomatous Cheilitis: A Case Report
Authors: Genece Jordan , Chu Justin , Liu Stephanie , Shihab Nahla , Ungar Jonathan
Published: March 2020

Introduction: Granulomatous cheilitis is a rare condition, with an unknown etiological pathway, resulting in inflammation of the lips. This case report demonstrates the efficacy of intralesional triamcinolone with this persistent disorder.Case report: A 19-year old man presented with orofacial swelling on the right side for approximately 18 months. Previous treatments of minocycline and metronidazole were unsuccessful. The patient has no other symptoms and an unremarkable family history. A regiment of topical anesthetic and intralesional triamcinolone showed significant improvement.Discussion: This rare condition has many possible contributory factors with very few established treatments. Our patient appeared to present either granulomatous cheilitis or monosymptomatic Melkersson-Rosenthal syndrome. Our primary goal was to abate the patient’s symptoms for their comfort, hence the implication of the benzocaine gel.Conclusion: There are various therapeutic methods described, however, we believe intralesional triamcinolone injections with prior application of topical anesthetic to ease discomfort, could be an alternative treatment.
Hyperpigmentation Associated with the Use of Topical Cidofovir for Treatment of Trichodysplasia Spinulosa in an Immunosuppressed Adult: Case Report and Review of the Literature
Authors: Nazarian Roya S. , Vyas Nikki S. , Evans John , Phelps Robert G.
Published: March 2020

Trichodysplasia spinulosa (TS) is a rare, opportunistic infectious skin disease caused by the polyoma virus.  Clinically, TS is characterized by follicular papules, keratin spicules, and alopecia most classically in a midfacial distribution. Since its discovery in 2010, no standard of treatment has been established, though use of oral acitretin, valganciclovir, lefludomide, topical cidofovir, physical extraction, and modification of immunosuppressive medications have been reported in the literature.  We describe the case of a 52-year old female with a painful midfacial eruption and alopecia of the bilateral eyebrows ultimately diagnosed with TS and treated with topical cidofovir 3%. Though the TS eruption resolved, treatment resulted in hyperpigmentation of the affected area. Hyperpigmentation associated with cidofovir use has been reported in cases of molluscum contagiosum, however, no such association has been described in the treatment of TS to our knowledge. Therefore, we report this case to highlight an underreported adverse effect of topical cidofovir in the setting of this rare disease.
Weight Gain Over Time in Hidradenitis Suppurativa Patients: Trends and Implications
Authors: McKenzie Shanice Alyssa , Patel Nirali , Harview Christina L , Truong Allison K , Chen Lucia Y , Grogan Tristan R , Shi Vivian Y , Bennett Richard G , Hsiao Jennifer Lin
Published: March 2020

Background: Hidradenitis suppurativa (HS) is often seen in overweight and obese patients. However, little is documented about weight gain over time in HS patients.Methods: From August 2009 to March 2018, all patients in the UCLA HS clinic were asked at initial examination about their weight gain since high school.Results: A cohort of 143 HS patients were found to have a significant mean BMI increase of 4.7 (25.5 to 30.2, p<0.0001) from high school until time of presentation (approximately a 15-year interval). Of the patients with ≥10 point BMI increase, 85.2% were women. 59.6% of women were normal weight in high school with an average BMI of 24.8 (SD 6.41, range 14-50) and 78.7% were overweight or obese at time of HS clinic intake. Hispanic HS patients were found to have more weight gain than other ethnic groups, (p=0.09) which may be clinically significant.Conclusions: Although many HS patients were normal weight or mildly overweight in high school, most become obese in early adulthood. Since obesity is thought to increase HS severity, weight management should be stressed in HS patients early on before weight gain occurs.
Oral Contraception Inducing Bullous Pemphigoid in an Adolescent
Authors: Wheless Margaret C , Zelickson Blake Reid , Patel Tejesh S , Jones Allison V
Published: March 2020

Abstract not available.
TNF-α Antagonist Induced Bullous Pemphigoid
Authors: Obayomi Aderonke O , Vick Garrett , Charbonnet Tamela
Published: March 2020

Abstract not available.
Pediatric Inflammatory Epidermolysis Bullosa Acquisita in a Patient with Oculocutaneous Albinism
Authors: Orlowski Timothy Jay , Hatch Michael M , Pavlidakey Peter , Kissel Rebecca , Graham Lauren V
Published: March 2020

Abstract not available.
Plant Stellate Trichomes: Strange Contaminants Appearing in KOH Preparations
Authors: Yi Lauren G , Forrester Vernon J , Timko Michael P , Wilson Barbara B
Published: March 2020

Abstract not available.
Biologic Prescribing Patterns Among Mount Sinai Psoriasis Patients: Results of a Retrospective Chart Review
Authors: Choy Alexa Haley , Vebman Jonathan , Yao Christopher
Published: March 2020

Objectives: Psoriasis is a painful and chronic inflammatory skin condition that not only impacts the quality of life of patients but is also a socioeconomic burden due to the cost of treatment, particularly with biologic treatments. The purpose of the study is to understand biologic prescribing patterns among Mount Sinai psoriasis patients and assess its relationship to insurance policy, which may limit treatment access.Methods: This study reviewed randomized, de-identified charts of psoriasis patients in a nine physician academic practice at Mount Sinai (New York, United States) with the following insurers: Aetna, Blue Cross Blue Shield, Empire Blue Cross Blue Shield, Medicare A&B, and United Healthcare, treated with the following biologics: secukinumab, etanercept, adalimumab, infliximab, brodalumab, ustekinumab, ixekizumab and guselkumab. A chi-square test was performed to compare prescribed biologics by insurance policy.Results:  Ustekinumab was the most prescribed biologic treatment across all the insurance plans. There were also disproportionate prescriptions of certain biologics for patients under particular insurance plans. Etanercept, brodalumab, and infliximab were the least prescribed biologics.Conclusion: Results highlight certain patterns in the prescribed biologics of Mount Sinai patients. Prescribed biologics tend to vary by different insurers. However, ustekinumab was the most frequently prescribed biologic among all insurers, though it is not the most efficacious biologic based on PASI responses.  Future research should be conducted to assess how differences in insurance policies (e.g., cost to patient) affect biologic prescribing.
Letter to the Editor: Commentary on "Stigmatizing attitudes towards persons with psoriasis among laypersons and medical students"
Authors: Guda Anisha , Browning John
Published: March 2020

Abstract not available.
Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis
Authors: Vebman Jonathan Ilai , Choy Alexa , Yao Christopher
Published: March 2020

Introduction: Psoriasis is a common disease that is linked with several other diseases. Our goals were to analyze and present literature on prevalence of various psoriatic comorbidities, and provide an estimate of what percent of psoriasis patients might have or develop Myocardial/cardiovascular/heart disease, stroke, diabetes, obesity, hypertension, or metabolic syndrome.Method: To collect the results, we searched PubMed to identify papers that studied the frequency of the most common comorbidities of psoriasis. We used about 20. The search terms used were the particular comorbidity (or synonyms) and psoriasis. Papers were selected where the prevalence data were listed by percentages of the studied population. Prevalence data from each paper were collected and charted, and then compared. We did not use data that concerned Psoriatic Arthritis. We also recorded outliers, where frequencies did not fit with the other data found.Results: Results for prevalence of myocardial/cardiovascular/heart disease were mixed, varying by age and severity of disease. There are few papers on prevalence of stroke, but our review suggests risk of stroke increases with severity of psoriasis. The prevalence of diabetes was largely between 10% and 20%. Obesity’s prevalence was mostly between 15% and 30%, while hypertension hovered around 30%, and metabolic syndrome prevalence was mostly between 27% and 50%.Conclusions: There are many comorbidities of psoriasis. The complex interaction between cutaneous inflammation and heart disease, stroke, diabetes, hypertension, and metabolic syndrome raises many questions about cause and effect or simple association.
Psoriasis in Pregnancy: A Review
Authors: Shihab Nahla , Tyutyunik Michael , Lebwohl Mark
Published: March 2020

Psoriasis is a complex autoimmune disease, most commonly characterized by silvery scale erythematous plaque. During pregnancy, there is a physiologic change of immunology status, which shifts from an inflammatory state to an anti-inflammatory state, in order to avoid fetal rejection. As a result of this immunomodulatory changes, the majority of pregnant patients experience improvement of their psoriasis. The treatment of psoriasis in pregnancy can be challenging, mainly because there is only a few evidence-based studies. The objective of this paper is to review the relevant data on psoriasis in pregnancy and its treatment.
Risk Stratification of Severely Dysplastic Nevi by Non-Invasively Obtained Gene Expression and Mutation Analyses
Authors: Jackson Cullison Stephanie Renae , Jansen Burkhard , Yao Zuxu , Ferris Laura K
Published: March 2020

Background: Strategies to non-invasively detect cutaneous melanoma generally focus on differentiating melanoma from non-melanoma lesions. However, given the variabilities in practice and lack of guidelines, it is important for clinicians to understand how such strategies and technologies perform on borderline lesions of uncertain clinical behavior. Objective: To evaluate LINC and PRAME gene expression and the presence of somatic mutations in BRAF, NRAS, and/or TERT in severely dysplastic nevi (SDN) and to assess, how combining gene expression and mutation analyses may impact test performance.Materials and Methods: One hundred three eligible skin lesions clinically suspicious for melanoma were non-invasively sampled via adhesive patches to enable genomic analyses. Afterward, these same lesions were immediately surgically biopsied to enable comparisons of genomic analyses with histopathologic diagnoses rendered by a panel of three dermatopathologists.  Twenty-three of these lesions analyzed were deemed borderline lesions of SDN histology by at least one dermatopathologist. RNA-based gene expression positivity by Pigmented Lesion Assay (PLA) analysis was defined by detectable levels of LINC and/or PRAME. DNA-based mutation positivity was defined as detection of somatic mutations in BRAF (non-V600E), NRAS, and/or the TERT promoter. Results: Adding TERT mutation analyses to PLA gene expression increases the test’s sensitivity to rule out melanoma from 93% to 97% in this study.  In addition, 61% of PLA positive lesions that were not diagnosed as melanoma were found to have severe histologic atypia. PLA-positive lesions histopathologically diagnosed as melanomas harbored TERT mutations in 70% of cases while both SDN and non-melanoma lesions including nevi without severe histologic atypia harbored TERT mutations in 4% of cases.  BRAF non-V600E and NRAS mutations were only found in the melanoma group and adding these mutations did not further enhance the test’s sensitivity. Conclusions and Relevance: PLA positivity increases with histologic atypia of pigmented skin lesions. Combining TERT mutation analyses with melanoma-associated gene expression provides additional genetic information to further non-invasively risk-stratify pigmented lesions.  These findings furthermore support that pigmented lesions exist on a spectrum of genomic atypia that may prove useful in identifying borderline lesions beyond their morphological appearance.
Clear Cell Squamous Cell Carcinoma: Clinical and Histologic Parameters and a Review of the Literature
Authors: Loesch Mathew , Ganocy Stephen J , Jaworsky Christine
Published: March 2020

Background: Clear cell squamous cell carcinoma (ccSCC) is an uncommon subtype of squamous cell carcinoma. This tumor subtype arises more commonly in elderly individuals and occurring greater upon sun-exposed areas of the body.Objective: To determine the age range and locations of ccSCC, and occurrence in men as compared with women.Methods: An observational study of ccSCC accessioned at a dermatopathology laboratory (Cleveland Skin Pathology, CSP) over an 18-month interval. Cases were retrieved and included based on a search of the terms “clear cell squamous cell carcinoma” in the diagnosis field of the CSP database and reviewed for accuracy and the degree of clear cell change in each lesion. Pathology requisition forms from these cases were used only to identify patients’ age, gender, and anatomic region of the ccSCC reviewed.Results: Of the 17,838 cases of in situ and invasive SCC, there were a total of 107 ccSCC, 77 in situ and 30 invasive (0.6% of total SCC). Of patients with ccSCC, 71% had a history of skin cancer, many (57.9%) in the same anatomic region. When the degree of clear cell change was evaluated there was no statistically significant increase of percentage clear cell change in tumors with age.Conclusions: Along with confirming past observations made with previous studies, our series shows that more men than women develop such tumors before 70 years of age, and more women than men after 70 years of age with men developing ccSCC on average 7 years earlier than women.
Successful Treatment of Pityriasis Rubra Pilaris with Brodalumab
Authors: Khan Umair , Shihab Nahla , Phelps Robert G , Lebwohl Mark
Published: March 2020

Pityriasis Rubra Pilaris (PRP) is a rare inflammatory skin disease with highly variable clinical appearance. Treatment of PRP remains a challenge and has been mostly guided by case reports and case series. We report the first case of pityrisis rubra pilaris that is successfully treated with combination therapy of brodalumab and methotrexate.
Case Report of Reactive Angioendotheliomatosis
Authors: Gupta Naeha , Kamrani Payvand , Lountzis Nektarios , McClain Richard
Published: March 2020

Reactive angioendotheliomatosis (RAE) is a rare, typically self-limiting, angioproliferative disease that is commonly seen in patients with a variety of inflammatory and systemic diseases. RAE can clinically present as ulcerated, single or multifocal, violaceous papules or plaques. We report a case of a 59-year-old male with a complicated cardiac history who presented with biopsy-proven RAE on the thigh. The differential diagnosis of RAE can include Kaposi sarcoma and angiosarcoma, as well as other non-malignant cutaneous disease. These diagnoses must be excluded before correctly diagnosing and treating RAE. We review the common presentation of RAE along with criteria to exclude other possible diagnoses that can resemble RAE.
The Successful Treatment of Multiple Cutaneous Malignancies with HPV Vaccination: Case Report
Authors: Geizhals Solomon , Lebwohl Mark G
Published: March 2020

An elderly, immunocompetent patient presented multiple invasive squamous cell carcinomas of the keratoacanthoma subtype superimposed on a psoriatic plaque. After failing initial treatment with oral acitretin, alternative therapies were considered. Due to the patient’s advanced age, location of the tumors and extensive tumor burden, invasive therapy was deemed impractical. After careful consideration, the more novel approach of injecting the 9-valent HPV vaccine was performed. Ten months after the first dose, the patient’s skin displayed neither clinical or histologic evidence of any residual cancer. We believe that this is the second reported case of the 9-valent HPV vaccine successfully treating non-melanoma cutaneous malignancies.
ĐẶC ĐIỂM SINH SẢN CỦA CÁ TỲ BÀ BƯỚM HỔ (Sewellia lineolata) TẠI TỈNH THỪA THIÊN HUẾ
Authors: Điều Võ , Việt Trần Văn , Thảo Phan Đỗ Dạ
Published: March 2020

Tóm tắt: Tỳ bà bướm hổ (Sewellia lineolata) là loài cá cảnh đang được khai thác từ tự nhiên để phục vụ nhu cầu nuôi cảnh trong nước và xuất khẩu. Tuy nhiên, đến nay chưa ghi nhận được nghiên cứu nào về đặc điểm sinh sản loài cá này. Nghiên cứu này đánh giá đặc điểm sinh sản của cá Tỳ bà bướm hổ tại tỉnh Thừa Thiên Huế. Tổng số 3.719 mẫu được thu từ tháng 1 năm 2017 đến tháng 8 năm 2018 để đánh giá các chỉ tiêu: xác định tỷ lệ đực/cái, các chỉ số độ béo Fulton và Clark, các giai đoạn phát triển tuyến sinh dục, hệ số thành thục sinh dục và kích thước thành thục. Kết quả cho thấy tỷ lệ đực/cái trong quần đàn tự nhiên là 0,76 (với 43,1% cá đực và 56,9% cá cái). Cả độ béo Fulton và Clark của cá đều biến động qua các tháng trong năm, trong đó đạt cao nhất vào tháng 3 và tháng 7. Mức độ phát triển của tuyến sinh dục và hệ số thành thục sinh dục của cá đạt cao vào hai đợt trong năm, đợt một từ tháng 10 năm trước đến tháng 1 năm sau và đợt hai từ tháng 4 đến tháng 6. Kích thước thành thục lần đầu đối với cá Tỳ bà bướm hổ đực là 45,04 mm và cá cái là 44,39 mm.Từ khóa: đặc điểm sinh sản, Sewellia lineolata, Thừa Thiên Huế, Tỳ bà bướm hổ
ỨNG DỤNG VIỄN THÁM VÀ GIS CÓ SỰ THAM GIA ĐỂ XÂY DỰNG BẢN ĐỒ PHÂN VÙNG NGUỒN NƯỚC TƯỚI CHO ĐẤT TRỒNG LÚA TRONG ĐIỀU KIỆN HẠN HÁN TẠI HUYỆN HÒA VANG, THÀNH PHỐ ĐÀ NẴNG
Authors: Phượng Trần Thị , Phượng Trương Đỗ Minh , Hà Trịnh Ngân , Chương Huỳnh Văn
Published: March 2020

Tóm tắt: Trong điều kiện sản xuất nông nghiệp bị ảnh hưởng bởi hạn hán, nhu cầu nước tưới ngày càng tăng. Việc cung cấp các thông tin về phân bố không gian của hệ thống tưới tiêu cho hoạt động canh tác lúa là hết sức cần thiết cho công tác quản lý tài nguyên nước và lập kế hoạch sử dụng đất. Nghiên cứu này được thực hiện nhằm xây dựng bản đồ phân vùng nguồn nước tưới cho đất trồng lúa bằng cách ứng dụng kết hợp viễn thám với GIS có sự tham gia cho huyện Hòa Vang, thành phố Đà Nẵng. Phương pháp phân loại theo định hướng đối tượng được sử dụng để giải đoán ảnh Sentinel 2A và phương pháp khảo sát thực địa để xây dựng bản đồ lớp thực phủ và bản đồ hệ thống nguồn nước mặt năm 2018 với độ chính xác cao. Thông qua việc sử dụng kết hợp với phương pháp thu thập số liệu và phương pháp GIS có sự tham gia của các bên liên quan, đề tài đã xây dựng được bản đồ phân vùng nước tưới cho diện tích đất trồng lúa của 11 xã thuộc huyện Hòa Vang. Đây sẽ là cơ sở hỗ trợ cho các ban ngành trong việc ra quyết định liên quan đến quản lý nguồn nước và lập kế hoạch sử dụng đất trồng lúa ở địa bàn nghiên cứu.Từ khóa: GIS có sự tham gia, đất trồng lúa, phân vùng nguồn nước tưới, phân bố không gian, viễn thám
FLIGHT-TO-QUALITY OR CONTAGION DURING U.S. SUBPRIME CRISIS: EVIDENCE FROM VIETNAM’S FINANCIAL MARKETS
Authors: Thanh Cong Bui , Khoa Cuong Phan , Bich Ngoc Tran Thi
Published: March 2020

Abstract: This study investigates whether contagion or flight-to-quality occurred in Vietnam’s financial markets during the US subprime crisis in 2007. We apply the asymmetric dynamic conditional correlation model (ADCC-GARCH (1,1)) to daily stock-index and bond index returns of Vietnam’s and US stock markets. We test for contagion or flight-to-quality by using a test for difference in dynamic conditional correlation means. The results show a contagion between the US and Vietnam’s stock markets, confirming the widespread influence of the US stock market on a young market like Vietnam. This result suggests a low benefit from diversification for investors holding portfolios containing assets in Vietnam’s stock market and US stock market during the crisis. Moreover, the relationship between Vietnam’s stock and bond markets represents a flight-to-quality during the US subprime crisis. This finding shows that the investors tend to hold less risky assets, i.e., bonds, instead of stocks during this turbulent period in Vietnam.Keywords: international financial contagion, flight-to-quality, Vietnam, US subprime crisis, ADCC-GARCH
PRECIZĂRI REFERITOARE LA PROBLEMA CALENDARULUI
Authors: VÎLCIU Marian
Published: March 2020

Since the very beginnings of his existence, mas was preoccupied by this phenomenon, and even if time is an abstract concept, as it can’t be divided, there was the preoccupation for a certain concretization of time, a system of measurement, so that, according to this periodization, man would be able to manage and unfold his social, material and religious life. This is why, from the most ancient times, men directed their attention towards different changes and phenomena of nature and, respecting the Holy Bible, they observed especially the astronomical phenomena
IMPORTANȚA PREDICII ȘI RESPONSABILITATEA PREDICATORULUI ÎN CONCEPȚIA ARHIMANDRITULUI IULIU SCRIBAN
Authors: BELDIMAN Nicușor
Published: March 2020

In his homiletic writings, the author illustrates the significance that speech has in preaching the Word of God and he describes it as the tool with which the priest fulfills the mission he was given by his Savior, to preach His Gospel to the world. Father Iuliu Scriban insists on several traits that characterize church language, stressing the idea that the Church has established very precise forms for expounding the truths of faith, for the use of the revealed Word. Thus, words must be the most suitable in respect with their contents; they must convey God’s will. He recommends that words without any impact or words that carry no emotion, no suggestive value, no authority, should be avoided.
CONCEPTUL DE PREZENȚĂ A LUI DUMNEZEU – LIANT ÎNTRE TEOLOGIA MISIONARĂ ȘI SPIRITUALITATEA CREȘTINĂ
Authors: PRESTOIU David
Published: March 2020

In a world of religious and moral dissolution, in which nihilist atheism and hedonistic consumerism prevail, missionary theology must propose to the secularized human the experience of reunion with God as a means of restarting the religious experience manifested concretely through prayer and intense spiritual life. Modernity has obviously fuelled deified conceptions, isolating God in an inaccessible transcendence, and promoting a total abandonment of the possibility of experiencing any form of real encounter with Him. The only way to get in touch with Him was rational knowledge, as it was found in the Bible, or logical deductions resulting from the dialogue between theology and science. But they dangerously lead to the postmodern concept of a God-idea, concept, force, etc., lacking the attribute of personality. According to Orthodox doctrine, God has a personal character, being, more specifically, a Trinity of Persons.
EXEGEZA SFINTEI SCRIPTURI A SFINȚILOR PĂRINŢI, CU PRIVIRE LA BISERICĂ
Authors: ŞTEFAN Florea
Published: March 2020

The present study deepens the Exegesis of the Holy Scriptures to the Holy Fathers regarding the Church. Appreciating the world of their time through the lens of Scripture, the Holy Fathers knew how to be guides of their time, readers of God's signs and indicators of the path of eternity, when darkness seemed to be more active in the world. As people aware of Scripture updating in their day, the Holy Fathers served the Church, the faithful people of God, were not only supporters of the Church, in a world, all the time, ready to devour their children, but more it's the parents.