bluuebunny/crossref_metadata_2025 huggingface dataset:
Brane with transverse rotation and background fields: boundary state and tachyon condensation
Authors: Kamani Davoud
Published: July 2020

The boundary state corresponding to the Dp-brane with a transverse rotation in the presence of the Kalb–Ramond and tachyon background fields and a U(1) internal field will be constructed. We shall investigate effects of the open string tachyon condensation on this brane via its boundary state. We demonstrate that the background fields and transverse rotation cannot protect the brane against the collapse. Our calculations are in the context of the bosonic string theory.
Deformations of the tangent bundle of projective manifolds
Authors: Peternell Thomas
Published: July 2020

We investigate when the tangent bundle of a projective manifold has a nontrivial first-order (or positive-dimensional) deformation. This leads to a new conjectural characterization of the complex projective space.
On Second-Order Composed Proto-Differentiability of Proper Perturbation Maps in Parametric Vector Optimization Problems
Authors: Tung Le Thanh
Published: July 2020

The main aim of this paper is to study second-order sensitivity analysis in parametric vector optimization problems. We prove that the proper perturbation maps and the proper efficient solution maps of parametric vector optimization problems are second-order composed proto-differentiable under some appropriate qualification conditions. Some examples are provided to illustrate our results.
Gravitational analysis of neutral regular black hole in Rastall gravity
Authors: Ali Riasat , Asgher Muhammad , Malik M. F.
Published: July 2020

This paper is devoted to the tunneling radiation and quantum gravity effect on tunneling radiation of neutral regular black hole in Rastall gravity. We analyzed the tunneling radiation and Hawking temperature of neutral regular black hole by applying the Hamilton-Jacobi ansatz phenomenon. Lagrangian wave equation have been investigated by generalized uncertainty principle (GUP), using the WKB-approximation and calculated the tunneling rate as well as temperature. Furthermore, we analyzed the temperature of this neutral regular black hole in the presence of gravity. The stability and instability of neutral regular black hole are also analyzed.
Perturbative calculation of energy levels for the Dirac equation with generalized momenta
Authors: Maceda Marco , Villafuerte-Lara Jairo
Published: July 2020

We analyze a modified Dirac equation based on a noncommutative structure in phase space originating from a generalized uncertainty principle with a minimum length. The noncommutative structure induces generalized momenta and contributions to the energy levels of the standard Dirac equation. Applying techniques of perturbation theory, we find the lowest-order corrections to the energy levels and eigenfunctions of the Dirac equation in three dimensions for a spherically symmetric linear potential and for a square-well times triangular potential along one spatial dimension. We find that the corrections due to the noncommutative contributions may be of the same order as the relativistic ones, leading to an upper bound on the parameter fixing the minimum length induced by the generalized uncertainty principle.
To construct lumps, breathers and interaction solutions of arbitrary higher-order for a (4 + 1)-dimensional Fokas equation
Authors: Li Wei , Liu Yinping
Published: July 2020

In this work, by introducing a kind of parameters constraint to ensure that the well known formula of [Formula: see text]-soliton solutions works well not only for integrable systems, but also for non-integrable systems. Then for the [Formula: see text]-dimensional Fokas equation, based on this constraint and the modified [Formula: see text]-soliton solutions, we further construct its different types of higher-order wave solutions, especially new types of interaction solutions.
On the braid group representations coming from weakly group-theoretical fusion categories
Authors: Green Jason , Nikshych Dmitri
Published: July 2020

We prove that representations of the braid groups coming from weakly group-theoretical braided fusion categories have finite images.
Contribution of enhanced DWT and non-negative structured sparse representation for image super resolution: A performance analysis
Authors: Bhasha A. Valli , Reddy B. D. Venkatramana
Published: July 2020

The image super-resolution methods with deep learning using Convolutional Neural Network (CNN) have been producing admirable advancements. The proposed image resolution model involves the following two main analyses: (i) analysis using Adaptive Discrete Wavelet Transform (ADWT) with Deep CNN and (ii) analysis using Non-negative Structured Sparse Representation (NSSR). The technique termed as NSSR is used to recover the high-resolution (HR) images from the low-resolution (LR) images. The experimental evaluation involves two phases: Training and Testing. In the training phase, the information regarding the residual images of the dataset are trained using the optimized Deep CNN. On the other hand, the testing phase helps to generate the super resolution image using the HR wavelet subbands (HRSB) and residual images. As the main novelty, the filter coefficients of DWT are optimized by the hybrid Fire Fly-based Spotted Hyena Optimization (FF-SHO) to develop ADWT. Finally, a valuable performance evaluation on the two benchmark hyperspectral image datasets confirms the effectiveness of the proposed model over the existing algorithms.
Pannotia's mantle signature: the quest for supercontinent identification
Authors: Heron Philip J. , Murphy J. Brendan , Nance R. Damian , Pysklywec R. N.
Published: July 2020

A supercontinent is generally considered to reflect the assembly of all, or most, of the Earth's continental lithosphere. Previous studies have used geological, atmospheric and biogenic ‘geomarkers’ to supplement supercontinent identification. However, there is no formal definition of how much continental material is required to be assembled, or indeed which geomarkers need to be present. Pannotia is a hypothesized landmass that existed in the interval
c.
0.65–0.54 Ga and was comprised of Gondwana, Laurentia, Baltica and possibly Siberia. Although Pannotia was considerably smaller than Pangaea (and also fleeting in its existence), the presence of geomarkers in the geological record support its identification as a supercontinent. Using 3D mantle convection models, we simulate the evolution of the mantle in response to the convergence leading to amalgamation of Rodinia and Pangaea. We then compare this supercontinent ‘fingerprint’ to Pannotian activity. For the first time, we show that Pannotian continental convergence could have generated a mantle signature in keeping with that of a simulated supercontinent. As a result, we posit that any formal identification of a supercontinent must take into consideration the thermal evolution of the mantle associated with convergence leading to continental amalgamation, rather than simply the size of the connected continental landmass.
Language, Emotion, and the Politics of Vulnerability
Authors: Pritzker Sonya E.
Published: July 2020

Previous research on language and emotion in anthropology has demonstrated that rather than being a private, subjective, and prediscursive experience belonging to individuals, emotion is an intersubjective, emergent process that is not only everywhere in language but also everywhere language is. In this review, I discuss how recent research in linguistic anthropology and related fields has continued to build on such insights in investigations of the flow of affect across bodies, the ways in which politically situated ideologies of language and emotion function at various institutional scales, and the role of language and emotion in the enactment of agency. Overall, my discussion is framed in a consideration of how this body of work contributes both theoretically and methodologically to understanding the role that language and emotion play in mediating the dynamic relationship between vulnerability and political agency.
Beneficial Effect of N-Carbamylglutamate in a Neonatal Form of Multiple Acyl-CoA Dehydrogenase Deficiency
Authors: Stanescu Sinziana , Belanger-Quintana Amaya , Alcalde Martin Carlos , Pérez-Cerdá Silvestre Celia , Merinero Cortés Begoña , Gonzalez Pérez Belen , Fernández García-Abril Carmen , Arrieta Blanco Francisco , Palacios Valverde Esperanza , Martínez-Pardo Casanova Mercedes
Published: July 2020

Background. Multiple acyl-CoA dehydrogenase deficiency is an autosomal recessive disorder of the amino acid metabolism and fatty acid oxidation due to the deficiency of the electron transfer protein or electron transfer protein ubiquinone oxidoreductase. The clinical picture ranges from a severe neonatal lethal presentation to late myopathic forms responsive to riboflavin. Up to now, there is no effective treatment for the neonatal form, which exhibits severe metabolic acidosis, hyperammonemia, hypoketotic hypoglycemia, and rhabdomyolysis. We present the case of a child who has had a good long-term outcome after a typical neonatal onset, with a dramatic drop in ammonia levels during the initial metabolic decompensation crisis and adequate control even during intercurrent diseases thereafter with N-carbamylglutamate treatment.
Effect of Missing Data Imputation on Deep Learning Prediction Performance for Vesicoureteral Reflux and Recurrent Urinary Tract Infection Clinical Study
Authors: Köse Timur , Özgür Su , Coşgun Erdal , Keskinoğlu Ahmet , Keskinoğlu Pembe
Published: July 2020

Missing observations are always a challenging problem that we have to deal with in diseases that require follow‐up. In hospital records for vesicoureteral reflux (VUR) and recurrent urinary tract infection (rUTI), the number of complete cases is very low on demographic and clinical characteristics, laboratory findings, and imaging data. On the other hand, deep learning (DL) approaches can be used for highly missing observation scenarios with its own missing ratio algorithm. In this study, the effects of multiple imputation techniques MICE and FAMD on the performance of DL in the differential diagnosis were compared. The data of a retrospective cross‐sectional study including 611 pediatric patients were evaluated (425 with VUR, 186 with rUTI, 26.65% missing ratio) in this research. CNTK and R 3.6.3 have been used for evaluating different models for 34 features (physical, laboratory, and imaging findings). In the differential diagnosis of VUR and rUTI, the best performance was obtained by deep learning with MICE algorithm with its values, respectively, 64.05% accuracy, 64.59% sensitivity, and 62.62% specificity. FAMD algorithm performed with accuracy = 61.52, sensitivity = 60.20, and specificity was found out to be 61.00 with 3 principal components on missing imputation phase. DL‐based approaches can evaluate datasets without doing preomit/impute missing values from datasets. Once DL method is used together with appropriate missing imputation techniques, it shows higher predictive performance.
A Robust Control Strategy for Landing an Unmanned Aerial Vehicle on a Vertically Moving Platform
Authors: Aguilar-Ibanez Carlos , Suarez-Castanon Miguel S. , Gutierrez-Frias Octavio , Rubio Jose de Jesus , Meda-Campana Jesus A.
Published: July 2020

In this work, we solve the uncertain unmanned aerial vehicle smooth landing problem over a moving platform, assuming that the aircraft position relative to the platform and its acceleration is always measurable. The landing task is carried out by an output-feedback robust controller, together with a repulsive force. The robust controller controls the nominal model, accomplishes the needed tracking trajectory, and counteracts the unknown uncertainties. To assure that the aircraft is always above the platform, we include a repulsive force that only works in a small vicinity of the platform. To estimate the relative aircraft velocity and platform acceleration, we use a supertwisting-based observer, assuring finite-time convergence of these signals. This fact allowed us to design the feedback state stabilizer independently of the observer design (in accordance with the separation principle). We confirmed the effectiveness of our control approach by convincing numerical simulations.
A Method of Constructing Robotics Service Platform for Assisting Handicapped or Elderly People
Authors: Yin Zuozhong , Wang Dianpeng , Liu Jihong
Published: July 2020

In order to solve the problem of demand for large capacity storage and high-performance computing resource of intelligent robot navigation and demand-service matching in the field of assisting handicapped or elderly people, overcoming the limitations of carrying resources, the method of constructing robot service platform for assisting handicapped or elderly people (RSP-AHEP) was proposed based on cloud robotics technology. Firstly, the demand of assisting handicapped or elderly people and the corresponding robot service category was analyzed to assure relationship-matching subjects. Secondly, based on VMware and Hadoop cluster technology, the architecture of a three-layer robot service platform was designed, which were universal interface layer, resource service layer, and application layer. Complex computing tasks, such as the matching computing between robot service and demand of the handicapped or elderly people, and the robot path-planning service, were placed in the robot service platform with the advantages of storage and computing resources. Thirdly, the remote communication between the robot and the service platform was realized based on the ROS (Robot Operation System) technology; finally, the function experiments, which included the remote dispatch, path planning, and service response between the service platform and robot, were carried out in the simulation environment. The result verified the feasibility of the proposed method.
Characterization and Goodness-of-Fit Test of Pareto and Some Related Distributions Based on Near-Order Statistics
Authors: Akbari Masoumeh
Published: July 2020

In this paper, a new definition of the number of observations near the kth order statistics is developed. Then some characterization results for Pareto and some related distributions are established in terms of mass probability function, first moment of these new counting random variables, and using completeness properties of the sequence of functions xn,0<x<1,n≥1. Finally, new goodness-of-fit tests based on these new characterizations for Pareto distribution are presented. And the power values of the proposed tests are compared with the power values of well-known tests such as Kolmogorov–Smirnov and Cramer-von Mises tests by Monte Carlo simulations.
Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases
Authors: Dou Manman , Chen Ying , Hu Jian , Ma Di , Xing Yingqi
Published: July 2020

Cardiovascular and cerebrovascular diseases caused by atherosclerosis have a high disability rate and reduce the quality of life of the population. Therefore, understanding the mechanism of atherosclerosis and its control may interfere with the progression of atherosclerosis and thus control the occurrence of diseases closely related to atherosclerosis. TSP‐1 is a factor that has been found to have an antiangiogenic effect, and CD47, as the receptor of TSP‐1, can participate in the regulation of antiangiogenesis of atherosclerosis. VEGF is an important regulator of angiogenesis, and TSP‐1/CD47 can cause VEGF and its downstream expression. Therefore, the TSP‐1/CD47/VEGF/VEGFR2 signal may have an important influence on atherosclerosis. In addition, some inflammatory factors, such as IL‐1 and NLRP3, can also affect atherosclerosis. This review will be expounded focusing on the pathogenesis and influencing factors of atherosclerosis.
Screening of Antioxidant and Antimicrobial Activity of Micromeria fruticosa serpyllifolia Volatile Oils: A Comparative Study of Plants Collected from Different Regions of West Bank, Palestine
Authors: Salameh Nihaya , Shraim Naser , Jaradat Nidal , El Masri Motasem , Adwan Lina , K’aibni Shadi , Alkowni Raed , Radwan Asma , AbuAlhasan Murad
Published: July 2020

Background. The investigation of volatile oils used in traditional medicine is vital to enhance the quality of healthcare. This study is aimed at screening the antioxidant and antimicrobial properties of Micromeria fruticosa serpyllifolia volatile oils from three different regions in Palestine (north, middle, and south). Methods. Volatile oils of three samples of M. fruticosa serpyllifolia were extracted using the microwave‐ultrasonic apparatus. The antioxidant activity of the volatile oils was assessed by inhibition of DPPH free radical. The antimicrobial activity was examined using the broth microdilution method. Assessment of antifungal activity was achieved using the agar dilution method. Results. Screening the biological activity of plant extracts revealed that the sample from Ramallah (middle region) possessed the most potent antioxidant activity with an IC50 value of 0.45 μg/mL. The three samples exhibited broad antimicrobial activity and showed potential antifungal activity. The sample from the southern region showed the highest potency against Shigella sonnei with the lowest reported MIC; the sample from the northern region demonstrated the least potency against clinical isolate of Staphylococcus aureus and “methicillin”‐resistant Staphylococcus aureus. Conclusions. The study showed that Micromeria fruticosa serpyllifolia volatile oil samples from different regions in Palestine possess different potential antioxidant and antimicrobial activities that were in line with traditional uses of the plant extracts.
Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
Authors: Su Gang , Ma Xiaohong , Wei Haidong
Published: July 2020

Lung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process through different pathways. Here, we mainly discussed the mechanism of crosstalk between alveolar epithelial cells and different immune cells through extracellular vesicles in lung inflammation and reviewed the mechanism of extracellular vesicles released by blood and airways on lung inflammation. Finally, the role of extracellular vesicles in viral infection of the lung was also described.
The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials
Authors: Mahdipour Elahe , Sahebkar Amirhossein
Published: July 2020

Background. Recombinant proteins and growth factors are emerging therapies for diabetic foot ulcers. Despite several clinical reports, there has been no comprehensive and systematic assessment of the totality of clinical evidence on the efficacy and safety of recombinant proteins and growth factors in diabetic foot ulcers. We tried to address this gap through an updated systematic review of randomized controlled trials (RCTs).Methods. PubMed, the Cochrane Library, Scopus, Embase, and Google Scholar databases were searched, and RCTs on the efficacy of recombinant proteins and growth factors in the treatment of cutaneous wounds in diabetic patients were selected. The literature search and assessment were performed by two independent reviewers. Methodological quality of studies was appraised using the Jadad scale.Results. We identified 26 RCTs involving diabetic patients with ulcer that evaluated the effectiveness of platelet-derived growth factor, epidermal growth factor, fibroblast growth factor, granulocyte colony-stimulating factor, vascular endothelial growth factor, erythropoietin, transforming growth factor, talactoferrin, and rusalatide acetate. The main primary outcome was complete healing though different indices were employed to define this such as wound closure, granulation tissue formation, or complete reepithelialization. Few studies had a follow-up period to report any recurrence and amputation rate. No adverse effect was reported due to the intervention.Conclusion. Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies.
Efficiency of Different Electrolytes on Electrochemical Chloride Extraction to Recover Concrete Structures under Chloride‐Induced Corrosion
Authors: Tofeti Lima Thamara , Ann Ki Yong
Published: July 2020

Chloride‐induced corrosion is one of the main causes of concrete deterioration and imposes a challenge to sustainability. Traditional techniques to repair corroded structures consisted of basically removing the damaged area, which was either economical or sustainable. Therefore, electrochemical chloride extraction (ECE) gained popularity for being an efficient nondestructive treatment applied temporarily to structures. On this line, this manuscript aims to raise the efficiency of ECE by an optimal decision of the treatment setup concerning the electrolyte choice. Three different electrolytes were tested, namely, tap water, calcium hydroxide, and lithium borate. Experimental results pointed to lithium borate as the most efficient electrolyte for extracting chlorides while calcium hydroxide was a better choice to repassivate the structure and even heal cracks, due to a possible electrodeposition of the electrolyte ions on the cement matrix. Thus, depending on the main goal of the treatment, different electrolytes achieve a better performance, which highlights the importance of pretreatment evaluation to see in which stage of corrosion damage is the structure.
Associations between Physical Fitness, Bone Mass, and Structure in Older People
Authors: Moradell A. , Gómez-Cabello A. , Gómez-Bruton A. , Muniz-Pardos B. , Puyalto J. Marín , Matute-Llorente A. , Gónzalez-Agüero A. , Ara I. , Casajús J. A. , Vicente-Rodríguez G.
Published: July 2020

The main aim was to analyse the associations between several physical fitness variables and bone parameters in a sample of elderly people. 129 participants (94 females and 35 males, 76.2 ± 5.4 y) from the EXERNET cohort of Zaragoza (Spain) were included in the study. Physical fitness was assessed using the Senior Fitness Test Battery. Peripheral quantitative computed tomography (pQCT) at the tibia and dual‐energy X‐ray absorptiometry (DXA) at the hip and lumbar spine were used to assess bone and muscle parameters. Partial correlations were used to describe the associations between fitness and bone parameters. A stepwise regression analysis was used to determine the influence of fitness variables on bone parameters. In males, significant correlations were found between lower body strength and agility with bone total mineral density (Tt.BMD) (r = 0.41 and ‐0.50) and cortical thickness (r = 0.40 and ‐0.50, respectively) and walking speed with total and cortical density (r = −0.41 and ‐0.40, respectively), all measured at tibia (all p < 0.05). Regarding DXA, neck areal bone mineral density (aBMD) correlated with flexibility (r = −0.37) and walking speed (r = 0.39) and Ward’s triangle with walking speed (r = 0.39). Agility predicted Tt.BMD and cortical thickness (r2 change = 24.8% and 23.0%), while walking speed predicted cortical bone mineral density (r2 change = 19.5%) (all p < 0.05). Females showed correlations between balance and total hip aBMD (r = 0.27) and trochanter aBMD (r = 0.25). Balance predicted trochanter (r2 change = 4.2%) and total hip aBMD (r2 change = 4.9%) (both p < 0.05). In conclusion, bone mass in elderly males seems to be more influenced by physical fitness than in females, being agility and walking speed the variables showing greater associations. Other variables should be taken into account in females for future research.
CSR Image Construction of Chinese Construction Enterprises in Africa Based on Data Mining and Corpus Analysis
Authors: Zhong Yaoping , Zhu Wenzhong , Zhou Yingying
Published: July 2020

Since there is negative coverage of some western media on the business activities of Chinese overseas enterprises, which has adverse impact on the image of Chinese enterprises and even the national image of China, this study aims to detect the corporate social responsibility image (hereafter CSR image) of Chinese construction enterprises in Africa (hereafter CCEA) through analyzing the coverage of Financial Times (hereafter FT) from the UK and The Wall Street Journal (hereafter WSJ) from the US and dig up the motives behind their coverage. Octopus is first applied to mine and collect the reports data on CCEA from 2011 to 2019 by the two media. Two small corpora including the reports are then built. NVivo is next used to do the statistical analysis and clustering analysis of the keywords in two corpora as a whole and AntConc is finally utilized to do the statistics of high-frequency evaluative adjectives and nouns modified by evaluative adjectives as well as the concordance of the low-frequency words but closely relevant to corporate social responsibility (hereafter CSR) in two corpora, respectively. The results of the detailed analyses of the keywords are combined to unveil the CSR image of CCEA, which is followed by a discussion about the motives behind the coverage and finally some suggestions are put forward to improve the CSR image of CCEA. Theoretically, the present study promotes the interaction among data science, management, communications, and linguistics; practically it offers some advice to CCEA to elevate their CSR image.
Postpartum-Onset Moyamoya Disease: A Rare Cause of Stroke in Unexpected
Authors: Ozer Muhammet , Merchant Khadija , Manning Zulfiya , Goksu Suleyman Yasin , Juneja Kirti , Fennell Vernard S.
Published: July 2020

Moyamoya disease (MMD) is a chronic cerebrovascular occlusive disease that is characterized by progressive bilateral stenosis of the terminal portion of the internal carotid artery and its main branches. Cerebrovascular events are the primary presenting symptoms and are related both to stenosis and occlusion of the ICAs and their main branches. Detection of bilateral stenosis by cerebral angiography is considered the gold standard, but computed tomography angiography (CTA) is also an acceptable method of diagnosis. In the current literature, there are no precise data on the incidence of moyamoya disease in Europe and the United States. Also, the pathogenesis of MMD remains obscure, and genetic factors and inflammation are the two most representative mechanisms. Here, we report the case of MMD in a 29-year-old African American female who presented with an ischemic stroke for the second time that manifested after pregnancy. This case is important to increase awareness of the probability of this rare disease in Western countries as well as to call attention to pregnancy’s accelerating effects of MMD. Careful, long-term neurologic and radiologic follow-up is essential in adult patients with MMD to prevent additional stroke events and improve outcomes.
The Clinical Effectiveness of Cognitive Behavioral Therapy for Patients with Insomnia and Depression: A Systematic Review and Meta‐Analysis
Authors: Feng Guiyu , Han Mei , Li Xun , Geng Le , Miao Yingchun
Published: July 2020

Background. Insomnia and depression often co‐occurr. However, there is lack of effective treatment for such comorbidity. CBT‐I has been recommended as the first‐line treatment for insomnia; whether it is also effective for comorbidity of insomnia and depression is still unknown. Therefore, we conducted this meta‐analysis of randomized controlled trials to assess the clinical effectiveness and safety of CBT‐I for insomnia comorbid with depression. Data Sources. Seven electronic databases, including China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science Technology Journal Database, SinoMed Database, PubMed, the Cochrane Library, and EMBASE, as well as grey literature, were searched from the beginning of each database to July 1, 2019. Study Eligibility Criteria. Randomized controlled trials that compared CBT‐I to no treatment or hypnotics (zopiclone, estazolam, and benzodiazepine agonist) for insomnia comorbid with depression and reported both insomnia scales and depression scales. Study Assessment and Synthesis Methods. Cochrane Reviewer’s Handbook was used for evaluating the risk of bias of included studies. Review Manager 5.3 software was used for meta‐analysis. Online GRADEpro was used to assess the quality of evidence. Results. The pooled data showed that CBT‐I was superior to no treatment for insomnia, while it was unsure whether CBT‐I was better than no treatment for depression. And the effectiveness of CBT‐I was comparable to hypnotics for both insomnia and depression. CBT‐I was likely to be safe due to its noninvasive nature. The methodological quality varied across these trials. The evidence quality varied from moderate to very low, and the recommendation level was low. Conclusions. Currently, findings support that CBT‐I seems to be effective and safe for insomnia comorbid with depression to improve the insomnia condition, while it is unsure whether CBT‐I could improve depression condition. More rigorous trials are needed to confirm our findings.
A Novel Approach to Ensemble Classifiers: FsBoost-Based Subspace Method
Authors: Noor Adeeb , Uçar Muhammed Kürşad , Polat Kemal , Assiri Abdullah , Nour Redhwan
Published: July 2020

In this article, an algorithm is proposed for creating an ensemble classifier. The name of the algorithm is the F-score subspace method (FsBoost). According to this method, the features are selected with the F-score and classified with different or the same classifiers. In the next step, the ensemble classifier is created. Two versions that are named FsBoost.V1 and FsBoost.V2 have been developed based on classification by the same or different classifiers. According to the results obtained, the results are consistent with the literature. Besides, a higher accuracy rate is obtained compared with many algorithms in the literature. The algorithm is fast because it has a few steps. It is thought that the algorithm will be successful due to these advantages.
Bilateral Avulsion Fracture of the Fibula Head of the Knee Associated with Avulsion Fracture of the Iliotibial Band: A Rare Case of Fracture Segond Associated with Arcuate Fracture
Authors: de Alencar Neto Jonatas Brito , de Souza Clodoaldo José Duarte , Lopes Márcio Bezerra Gadelha , Cavalcante Maria Luzete Costa , Neto Luiz Holanda Pinto
Published: July 2020

Fibular head avulsion fractures are rare and are so-called the arcuate signal. Avulsion fracture of the iliotibial band and anterolateral ligament is known as a Segond fracture, and it is another rare entity. We describe the case of a 27-year-old woman who was hit by a car and suffered polytrauma, mainly suffering injuries to both knees. Radiographs of the knees showed a Segond fracture associated with the arched signal bilaterally. The aim of this study is to present a rare case report and literature review of a bilateral fibular head avulsion fracture associated with an anterolateral tibial avulsion fracture.
Cost-Benefit Models on Integrating Information Technology Services in Automotive Production Management
Authors: Hu Bin , Lv Jianlin , Yang Kun
Published: July 2020

The integration of the new-generation information technology and the automobile manufacturing industry has significantly improved the production efficiency of the automobile manufacturing industry, but it will also increase the technology application cost of the automobile manufacturing industry. The boundary value of the income change of the automobile manufacturing industry can be obtained by examining the influence of new-generation information technology on the price of parts, the price of automobiles, and the quantity of production in the upstream and downstream of the automobile manufacturing industry chain. The study found that the benefit of the automobile manufacturing industry that meets the conditions of technology application costs has increased. The value added to the downstream enterprises in the industrial chain is greater than the value added to the upstream companies. The lower the cost of technology application, the greater the impact on the number of automobile production. In the end, an example is used to verify the reliability of the research results.
Effect of Surface Roughness during Peristaltic Movement in a Nonuniform Channel
Authors: Shukla R. , Bhatt S. S. , Medhavi A. , Kumar R.
Published: July 2020

In this study, the effect of the roughness parameter during the peristaltic transport of a Newtonian fluid in a nonuniform channel has been explored. The motivation of this study comes from various research studies in the area of life sciences and engineering, which reveal that the wall of living beings’ arteries and all other surfaces have roughness to some extent. As peristalsis is a major mode of transporting biological fluids in various organs, the effect of surface roughness during peristaltic flow becomes very significant. The problem of peristaltic motion of a Newtonian fluid through a rough nonuniform channel having sinusoidal-shaped roughness has been investigated in the current work. To analyze the flow, analytic formulation of pressure rise, friction force, velocity, and pressure gradient has been carried out under the low Reynolds number and long-wavelength approximation. Results obtained for zero surface roughness from the current model are in complete agreement with previous studies available in the literature that have been carried out without considering the surface roughness of the wall. Numerical outcomes for the properties mentioned above have been plotted for analyzing the impact of roughness on the physical and flow parameters.
Transmission of HIV and HCV within Former Soviet Union Countries
Authors: Aibekova Lazzat , Bexeitova Aizada , Aldabergenova Arailym , Hortelano Gonzalo , Ge Zhangwen , Yi Feng , Shao Yiming , DeHovitz Jack , Vermund Sten H. , Ali Syed
Published: July 2020

Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne infections within and across the FSU countries. To examine the transmission of blood-borne infections within this region, we analyzed the phylogenetic relationship of publically available sequences of two blood-borne viruses, hepatitis C virus (HCV) and human immunodeficiency virus (HIV), from FSU countries. Methods. We analysed 614 and 295 NS5B sequences from HCV genotypes 1b and 3a, respectively, from 9 FSU countries. From 13 FSU countries, we analysed 347 HIV gag and 1282 HIV env sequences. To examine transmission networks and the origins of infection, respectively, phylogenetic and Bayesian analyses were performed. Results. Our analysis shows intermixing of HCV and HIV sequences, suggesting transmission of these viruses both within and across FSU countries. We show involvement of three major populations in transmission: injection drug user, heterosexual, and trans-border migrants. Conclusion. This study highlights the need to focus harm reduction efforts toward controlling transmission of blood-borne infections among the abovementioned high-risk populations in the FSU countries.
Can Molecular Imaging Measure T-cell Activation?
Authors: Choyke Peter L.
Published: July 2020

Successful immunotherapy usually depends on activation of T cells in the tumor microenvironment. However, ascertaining whether T-cell activation has occurred in vivo is difficult without invasive tissue sampling. Inducible T-cell costimulator (ICOS) is a specific marker of T-cell activation that can be imaged by radiolabeling an anti-ICOS antibody and performing PET scanning. Hopefully, this agent will be the first of many molecular imaging constructs that can determine whether T-cell activation has occurred and could be used in drug development and clinical trials of cancer immunotherapy.

See related article by Xiao et al., p. 3023
A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAFV600E/K-mutant Solid Tumors
Authors: Sullivan Ryan J. , Weber Jeffrey , Patel Sapna , Dummer Reinhard , Carlino Matteo S. , Tan Daniel S.W. , Lebbé Celeste , Siena Salvatore , Elez Elena , Wollenberg Lance , Pickard Michael D. , Sandor Victor , Ascierto Paolo A.
Published: July 2020

Purpose:

This open-label, dose-finding phase Ib/II study reports the safety and activity of the first combination use with BRAF inhibitor (BRAFi) encorafenib plus MEK inhibitor (MEKi) binimetinib in patients with BRAF V600E–mutant solid tumors.

Patients and Methods:

In phase I, the recommended phase 2 doses (RP2D) were established (primary objective). In phase II, the clinical activity of the combination at the RP2D was assessed (primary objective) in patients with BRAF-mutant metastatic colorectal cancer (mCRC), BRAFi-treated BRAF-mutant melanoma, and BRAFi-naïve BRAF-mutant melanoma.

Results:

A total of 126 patients with BRAF-mutant solid tumors were enrolled (phase I: 47 patients; phase II: 79 patients). The RP2D was encorafenib 450 mg once daily plus binimetinib 45 mg twice daily and pharmacokinetic data suggest that drug exposures of each agent were similar in combination compared with single-agent studies. In the phase II cohorts, confirmed responses were seen in two of 11 (18%) evaluable patients with mCRC, 11 of 26 (42%) evaluable patients with BRAFi-pretreated melanoma, and 28 of 42 (67%) BRAFi-naïve patients with melanoma. The most common grade 3/4 adverse event in phase II was increased alanine aminotransferase.

Conclusions:

The combination of encorafenib (450 mg) plus binimetinib (45 mg) showed acceptable tolerability and encouraging activity in patients with BRAF V600–mutant tumors, which led to the dose selection for the melanoma COLUMBUS study. The safety profile of the combination was consistent with other approved BRAFi plus MEKi regimens, with several differences, including lower rates of dose-limiting pyrexia, arthralgia, and photosensitivity.
Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study
Authors: Harrington Kevin J. , Kong Anthony , Mach Nicolas , Chesney Jason A. , Fernandez Beatriz Castelo , Rischin Danny , Cohen Ezra E.W. , Radcliffe Hoi-Shen , Gumuscu Burak , Cheng Jonathan , Snyder Wendy , Siu Lillian L.
Published: July 2020

Purpose:

The prognosis for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is poor, and only a minority of patients benefit from checkpoint immunotherapy. Talimogene laherparepvec (T-VEC), an oncolytic immunotherapy approved for advanced melanoma, in combination with pembrolizumab may yield enhanced antitumor activity over either agent alone.

Patients and Methods:

This was a phase Ib/III, multicenter trial testing intratumoral T-VEC combined with intravenous pembrolizumab in R/M HNSCC refractory to platinum-based chemotherapy. For phase Ib, primary endpoint was incidence of dose-limiting toxicity (DLT). Key secondary endpoints included objective response rate and progression-free survival per irRECIST, overall survival, and safety.

Results:

Thirty-six patients were enrolled into the phase Ib study. The data cut-off date was August 28, 2018. Median follow-up was 5.8 months (range, 0.3–24.2). One DLT of T-VEC–related fatal arterial hemorrhage was reported. Twenty (55.6%) and 21 (58.3%) patients experienced adverse events (AE) related to T-VEC and pembrolizumab, respectively. Besides the DLT, there were no treatment-related fatal AEs. A confirmed partial response was observed in 5 (13.9%) patients. Ten (27.8%) patients were unevaluable for response due to early death. Median PFS and OS were 3.0 months [95% confidence interval (Cl), 2.0–5.8] and 5.8 months (95% Cl, 2.9–11.4), respectively.

Conclusions:

The combination of T-VEC and pembrolizumab demonstrated a tolerable safety profile in R/M HNSCC. The efficacy with the combination was similar to that with pembrolizumab monotherapy in historical HNSCC studies. Phase III part of this study was not further pursued (ClinicalTrials.gov Identifier: NCT02626000).
Real power loss reduction by arctic char algorithm
Authors: Kanagasabai Lenin
Published: July 2020

This work presents Arctic Char Algorithm (ACA) for solving optimal reactive power problem. In North America movement of Arctic char phenomenon is one among the twelve-monthly innate actions. Deeds of Arctic char have been imitated to design the algorithm. In stochastic mode solutions are initialized with one segment on every side of to the route ascendancy; particularly in between lower bound and upper bounds. Previous to the movement, Arctic char come to a decision about the passageway based on their perception. This implies stochastic mix up of control parameters to push the Arctic char groups (preliminary solution) in mutual pathway (evolutionary operators). Projected Arctic Char Algorithm (ACA) has been tested in standard IEEE 14,300 bus test system and simulation results show the projected algorithm reduced the real power loss extensively.
Chaotic based Pteropus algorithm for solving optimal reactive power problem
Authors: Kanagasabai Lenin
Published: July 2020

In this work, a Chaotic based Pteropus algorithm (CPA) has been proposed for solving optimal reactive power problem. Pteropus algorithm imitates deeds of the Pteropus. Normally Pteropus while flying it avoid obstacles by using sonar echoes, particularly utilize time delay. To the original Pteropus algorithm chaotic disturbance has been applied and the optimal capability of the algorithm has been improved in search of global solution. In order to augment the population diversity and prevent early convergence, adaptively chaotic disturbance is added at the time of stagnation. Furthermore exploration and exploitation capability of the proposed algorithm has been improved. Proposed CPA technique has been tested in standard IEEE 14,300 bus systems & real power loss has been considerably reduced.
No limiar da escravidão
Authors: Silva Junior Waldomiro Lourenço
Published: July 2020

O objetivo do artigo é analisar conjuntamente dois debates jurídicos muito próximos no tempo, que trataram de circunstâncias em torno de pessoas escravizadas. Um deles, travado em Cuba em 1856, envolveu a coartación, que consistia na amortização gradual do montante correspondente à alforria. O outro, já bem conhecido em nossa historiografia, aconteceu no Brasil no ano seguinte, abordando aspectos da alforria condicional, que dizia respeito aos estado-livres (do latim statuliberi). Nos dois contextos, os juristas envolvidos entendiam diferentemente as prerrogativas dos indivíduos naquelas condições, alguns considerando-os mais próximos da escravidão, outros, mais próximos da liberdade. Após mapear as origens de princípios e normas fundamentais, destacando semelhanças estruturais e especificidades existentes entre as ordens normativas em vigor no escravismo cubano e brasileiro, o artigo se volta mais objetivamente para os argumentos tecidos nos debates. Em seu conjunto, o estudo busca explicitar a articulação de múltiplos tempos históricos na definição do quadro jurídico da escravidão em meados do século XIX
“Anjos anônimos, feitos de ternura”
Authors: Souza Marcos Santana de
Published: July 2020

O presente artigo tem como objetivo desenvolver uma análise histórica das alterações observadas no papel feminino na Polícia Militar de São Paulo durante os governos militares pós-golpe de 1964. Centrado, principalmente, na análise documental de registros jornalísticos, artigos, imagens e relatórios de serviço da atuação do efetivo feminino, o texto busca compreender os preceitos que marcaram o trabalho policial no período frente a importantes alterações no campo político e dos costumes. Pioneiro no emprego feminino nas ações de policiamento no país, o estado de São Paulo revela como na Polícia Militar as mulheres serviram como um importante instrumento para atuar no campo da assistência social, regulando o atendimento a imigrantes e no enfrentamento do problema do “menor”, assim como em outros campos destinados ao “combate” sutil ao avanço dos grupos políticos opositores. Assim, o trabalho das policiais femininas mostrou-se fundamental na construção do discurso de modernização da segurança pública no período.
O DIVINO NAS NARRATIVAS AINU
Authors: Silva Luana Bueno Barbosa Cyríaco da , Namekata Márcia Hitomi
Published: July 2020

Os Ainu são um povo indígena habitante tradicionalmente da região norte do Japão (ilha de Hokkaido), e também das ilhas Kurile e Sahkalin. Possuem uma cultura bem definida, bem como uma língua diferente do japonês (conhecida por Ainu Itak) e um rico repertório de literatura oral. Este trabalho pretende identificar algumas características que apresentam as histórias em forma de verso ou prosa, quando estas têm como personagens principais as entidades, conhecidas pelo nome de kamui.
ENTREVISTA COM TERUKO ODA
Authors: Tavares Débora Fernandes
Published: July 2020

Teruko Fujino Oda (1945-) é poeta e exerce um papel importante na disseminação do haikai no Brasil. Filha de imigrantes japoneses e sobrinha de Hidekazu Masuda (1911-2008), o Mestre Goga, um dos fundadores do Grêmio Haicai Ipê, desde a infância Teruko Oda viu-se cercada pela natureza onde vivia no interior de São Paulo e pela prática do haikai. À frente da coordenação do Grêmio Haicai Ipê desde 2012, nesta entrevista inédita concedida em março de 2017, Teruko conta-nos sobre o seu primeiro contato com o haikai, sobre as atividades desenvolvidas pelo Grêmio Haicai Ipê e suas expectativas para o futuro.
Novel Oral Anticoagulants Following Percutaneous Coronary Intervention
Authors: Abadie Bryan Q. , Cannon Christopher P. , Cavender Matthew A.
Published: July 2020

Antiplatelet and anticoagulant medications are the cornerstone of therapy for patients with acute coronary syndrome and have also been shown to reduce recurrent cardiovascular events in patients with stable coronary disease. Whereas antiplatelet medications have been the preferred therapy for long-term secondary prevention, the development of novel oral anticoagulants has renewed interest in the use of anticoagulation to prevent atherosclerotic events. In patients with atrial fibrillation or other indications for anticoagulation, recent clinical trials have shown the benefit of double therapy with full-dose novel oral anticoagulants and P2Y12 inhibitors compared with regimens with vitamin K antagonists. In patients without an indication for anticoagulation, the use of low doses of the factor Xa inhibitor, rivaroxaban, has shown benefit. Clinicians have many pharmacological options when treating patients following percutaneous coronary intervention. This review discusses the evidence for the use of novel oral anticoagulants, with an emphasis on patient selection, choice of therapy, and appropriate dosing of anticoagulant and antiplatelet agents, in secondary prevention strategies for atherosclerosis following coronary revascularization for patients with and without a traditional indication for anticoagulation.