bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic tactics with violations of the menstrual cycle caused by ovulative dysfunction
Authors: Dikke G. B.
Published: September 2018

Purpose: presentation of modern data on the pathogenesis of menstrual cycle disorders (NMCs) associated with ovulatory dysfunction, and the effectiveness of their treatment with medication.

Basic provisions. It is shown that NMC is the result of violations of the cyclic production of gonadotropic and sex hormones. Among the hormonal drugs for the treatment of NMCs, combined estrogen-progestational oral contraceptives (COCs), especially those with drospirenone (DRSP), are advantageous. The introduction of calcium levomefolate - biologically active form of folatein the composition of COCs containing 30 μg of ethinylestradiol and DRSP has a potentiating effect associated with their noncontraceptive effects due to antiandrogenic and antimineralocorticoid activity. It was shown that calcium levomefolate, which participates in human body metabolism, as a component of COC, has a protective effect on the cardiovascular system (due to a decrease in the level of homocysteinemia) in the syndrome of polycystic ovaries, contributes to reducing obesity.

Conclusion. The combination of 30EE/DRSP promotes the normalization of the menstrual cycle and has non-contraceptive effects associated with antiandrogenic and antimineralcorticoid action, and fortification with calcium levomefolate also has a positive effect on the hormonal profile and lipid metabolism, has a protective effect on cardiovascular diseases in women with the metabolic syndrome in polycystic ovaries, contributes to the normalization of weight.
The experience of using acetylsalicylic acid in a comorbid patient with cad and type 2 diabetes
Authors: Gorokhovskaya G. N. , Yun V. L. , Vasyuk Yu. A. , Maichuk E. Yu. , Martynov A. I.
Published: September 2018

The CVD death rates remain high now. The concurrent course of coronary artery disease (CAD) and diabetes mellitus (DM) has an unfavourable prognosis, requires specific therapy and the use of measures to prevent severe complications. DM sometimes hinders the timely diagnosis of CAD, which in this case is characterized by an atypical course and has no florid symptoms. This often causes serious pathological complications or death. The atherothrombosis forms the basis of pathogenesis of severe conditions. Atherothrombosis is not only a generalized, but also a constantly progressive disease, for which reason it is necessary to carry out both primary and secondary prevention. According to the existing guidelines of European Society of Cardiology and Society of Cardiology of Russian Federation, acetylsalicylic acid (ASA) is recommended at small doses as the first-line drug for the prevention of vascular events in patients with CAD. This article discusses the experience of using ASA according to the conducted studies and in practical medicine by the clinical example of a female patient.
The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies
Authors: Talevi Alan , Carrillo Carolina , Comini Marcelo
Published: September 2018

Chagas´ disease continues to be a challenging and neglected public health problem
in many American countries. The etiologic agent, Trypanosoma cruzi, develops intracellularly
in the mammalian host, which hinders treatment efficacy. Progress in the knowledge of parasite
biology and host-pathogen interaction has not been paralleled by the development of
novel, safe and effective therapeutic options. It is then urgent to seek for novel therapeutic
candidates and to implement drug discovery strategies that may accelerate the discovery process.
The most appealing targets for pharmacological intervention are those essential for the
pathogen and, whenever possible, absent or significantly different from the host homolog. The
thiol-polyamine metabolism of T. cruzi offers interesting candidates for a rational design of
selective drugs. In this respect, here we critically review the state of the art of the thiolpolyamine
metabolism of T. cruzi and the pharmacological potential of its components. On
the other hand, drug repurposing emerged as a valid strategy to identify new biological activities
for drugs in clinical use, while significantly shortening the long time and high cost associated
with de novo drug discovery approaches. Thus, we also discuss the different drug repurposing
strategies available with a special emphasis in their applications to the identification of
drug candidates targeting essential components of the thiol-polyamine metabolism of T. cruzi.
Development of Health Products from Natural Sources
Authors: Sansone Francesca , Mencherini Teresa , Picerno Patrizia , Lauro Maria Rosaria , Cerrato Michele , Aquino Rita Patrizia
Published: September 2018

BioActive Compounds (BACs) recovered from food or food by-product matrices
are useful in maintaining well being, enhancing human health, and modulating immune function
to prevent or to treat chronic diseases. They are also generally seen by final consumers
as safe, non-toxic and environment-friendly. Despite the complex process of production,
chemical characterization, and assessment of health effects, BACs must also be manufactured
in stable and bioactive ingredients to be used in pharmaceutical, food and nutraceutical industry.
Generally, vegetable derivatives occur as sticky raw materials with pervasive smell and
displeasing flavor. Also, they show critical water solubility and dramatic stability behavior
over time, involving practical difficulties for industrial use. Therefore, the development of
novel functional health products from natural sources requires the design of a suitable formulation
to delivery BACs at the site of action, preserve stability during processing and storage,
slow down the degradation processes, mask lousy tasting or smell, and increase the bioavailability,
while maintaining the BACs functionality. The present review focuses on human
health benefits, BACs composition, and innovative technologies or formulation approaches
of natural ingredients from some selected foods and by-products from industrial food transformations.
Oral Health and Dental Students’ Perceptions of Their Clinical Learning Environment: A Focus Group Study
Authors: Ebbeling Sarah , Adam Lee , Meldrum Alison , Rich Alison , McLean Angela , Aitken Wendy
Published: September 2018

Creating an optimal clinical learning environment poses a challenge to health professions educators. To evaluate and improve the clinical learning environment, it is necessary to understand students’ experiences of their environment and the factors they perceive as having an impact on their learning. The aim of this explorative qualitative study was to examine University of Otago Faculty of Dentistry students’ perceptions of their clinical learning environment to gain insights into how learning outcomes could be enhanced. In 2015, all approximately 600 students at all levels of the Bachelor of Oral Health and Bachelor of Dental Surgery degrees at the University of Otago, Dunedin, New Zealand, were invited to participate in focus groups. Focus groups facilitated by the faculty education research fellow and another researcher employed for the project were conducted during the second half of the academic year. Transcribed data were analyzed using a general inductive approach. Twenty‐one students from all levels of the two programs attended one of six confidential focus groups. Three broad themes were evident in the results from all groups: feedback processes, assessments and grading, and tutor interactions. In the focus groups, students expressed dissatisfaction regarding current feedback practices, types of feedback to benefit learning, consistency in the grading system, and impact of different educators’ teaching styles on learning. These results indicated a need for further research and curricular efforts to promote good student‐teacher relationships in the clinical learning environment, which are paramount for creating an optimal teaching and learning environment and enhancing student outcomes.
Evaluation of an Interprofessional Oral Health Assessment Activity in Advanced Practice Nursing Education
Authors: Estes Krista R. , Callanan Deidre , Rai Nayanjot , Plunkett Katie , Brunson Diane , Tiwari Tamanna
Published: September 2018

The curriculum for nurse practitioner (NP) students often overlooks the assessment of the oral cavity. In recognition of this, the HEENT (head, eyes, ears, nose, and throat) assessment was expanded to HEENOT (head, ears, eyes, nose, oral, and throat) through integration of an interprofessional educational (IPE) activity developed for University of Colorado NP and dental students. The aim of this study was to assess NP students’ perceptions of an IPE activity in which dental faculty and students taught NP students how to conduct an oral exam, recognize oral health pathology, and apply fluoride varnish. Afterwards, the NP students completed an evaluation survey focusing on their thoughts, comfort level, organization, and understanding of the activity. This IPE activity was repeated over four semesters from 2014 to 2017, and significant differences among the semesters were compared. All NP students in the four semesters participated in the activity and the survey: semester one N=25, semester two N=31, semester three N=43, and semester four N=25. In all semesters, NP students reported feeling more confident conducting oral health exams after completion of the IPE activity. Semester four students agreed more with the idea of interprofessional collaboration (OR: 0.103) and receiving educational information not learned elsewhere in the curriculum (OR: 0.134) compared to semester one students. Higher odds for the session being well organized and conducted in a suitable time were found for semester four compared to semester two (OR: 0.217). These comparisons reflect improvement in teaching methodologies over the four semesters and an overall increased confidence for NP students in performing an oral health assessment.
Preclinical Local Anesthesia Education in Dental Schools: A Systematic Review
Authors: Kary Andrew L. , Gomez Juliana , Raffaelli Samuel D. , Levine Marci H.
Published: September 2018

The aim of this systematic review was to evaluate the published literature on current educational techniques used to teach local anesthesia administration in U.S. dental schools to determine the methods by which potential complications may be minimized and efficacy maximized. A PubMed search was performed in June 2017 on the following terms: (local anesthesia, education, dental) AND (Humans[Mesh]). Out of 136 articles identified, 13 met the study criteria and were included for review. Of those, the nine with outcome measures were included in the qualitative synthesis. With a quality assessment tool designed for this study, the quality of each included article was assessed independently by three of the authors. Three main pedagogies were identified: didactic instruction based on textbooks and lectures, student‐to‐student injections, and use of anatomic models. However, the effects of these pedagogies on local anesthesia administration efficacy, patient satisfaction, and student confidence in administering local anesthesia were largely not assessed in these studies. Quality assessment of the reviewed articles yielded a mean score of 62% (range 44–83%) for the observational studies and a mean score of 56% (range 47–63%) for the interventional studies. Due to the heterogeneity of the studies assessed, no meta‐analysis could be performed. While the experimental and observational studies reviewed provided some insight into the efficacy of current educational techniques, they had numerous methodological inconsistencies. The inconsistency of the available evidence made it difficult to make fully informed curriculum recommendations based on the existing literature.
TREATABILITY OF OPIUM ALKALOID INDUSTRY WASTEWATERS BY ANAEROBIC PROCESSES
Authors: Çelen Erdem İpek , Türker Mustafa , Çiftçi Gülen , Öztürk İzzet , Çiftçi Talat
Published: September 2018

The effluents from alkaloid industry contain high levels of organic matter, alkalinity, salinity, color and sulphate. The treatment of this complex industrial wastewater was attempted in two stages anaerobic reactors. The effects of COD, conductivity, pH, alkalinity, sulphate and TKN on anaerobic treatment were evaluated. When the reactors were fed with original wastewater, VFA’s were accumulated in the presence of 25,794 mg/L COD and 30.2 mS/cm conductivity of the raw opium wastewater even at OLR of 1-3 kgCOD/m3day. However, stepwise dilution was applied and COD removal of 90% was achieved at OLR of 7-8kgCOD/m3day as the conductivity and COD were reduced to 20 mS/cm 20,000 mg/L, respectively. Based on the findings of this study, highly concentrated wastewaters of opium alkaloid industry wastewaters can be treated with anaerobic digestion and significant reduction of COD can be achieved.
Proton Pump Inhibitors, Histamine-2 Receptor Antagonists, and Hip Fracture Risk among Patients on Hemodialysis
Authors: Vangala Chandan , Niu Jingbo , Lenihan Colin R. , Mitch William E. , Navaneethan Sankar D. , Winkelmayer Wolfgang C.
Published: September 2018

Background and objectives

An association between proton pump inhibitor (PPI) use and hip fracture risk has been described in the general population, where the primary causative hypothesis focuses on impaired gastrointestinal calcium absorption. The impact of acid suppressor use on hip fracture risk in a high-risk subset, patients with ESKD requiring hemodialysis, is unknown and could help further distinguish the reason for higher susceptibility among PPI users.

Design, setting, participants, & measurements

Using the US Renal Data System, we identified all hip fracture events recorded between 2009 and 2014 among patients dependent on hemodialysis. Eligible cases were matched on index date with ten controls. We identified PPI and histamine-2 receptor antagonist use from Medicare Part D claims covering 3 years before the index date and stratified according to proportion of days covered by filled prescriptions. Using logistic regression with multiple imputation for missing data, we estimated unadjusted and multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

We studied 4551 cases and 45,510 controls. Patients were older, more likely to be female and white, and had shorter dialysis vintage; fewer were obese. A larger proportion of patients had any prior PPI (70% versus 63%) or histamine-2 receptor antagonist (25% versus 23%) use. Use of PPI was associated with higher risk of hip fracture (adjusted OR, 1.19; 95% CI, 1.11 to 1.28). This association remained within subgroups of low, moderate, and high PPI use, yielding adjusted ORs of 1.16 (95% CI, 1.06 to 1.27), 1.21 (95% CI, 1.11 to 1.31), and 1.19 (95% CI, 1.08 to 1.31), respectively.

Conclusions

Among patients with ESKD on hemodialysis, PPIs and not histamine-2 receptor antagonists were associated with hip fracture events.
Os vazios urbanos e o Direito à Cidade: Desafios da implementação do IPTU Progressivo em Campos dos Goytacazes/RJ
Authors: Gonçalves Bianca Siqueira , Da Cruz José Luis Vianna
Published: September 2018

Este estudo analisa a cidade como produção social, fruto da ação complexa e conflituosa de agentes sociais, que representam distintos interesses. Discorre sobre a dinâmica capitalista na construção do espaço na cidade e como se organizam as estruturas urbanas. Tendo como cenário a cidade de Campos dos Goytacazes/RJ, apura o papel e a importância do IPTU progressivo no acesso democrático ao solo urbano, conforme preconiza a legislação brasileira, enquanto instrumento de garantia do Direito à Cidade. Foram analisados os fatores que favorecem e permitem a existência de vazios urbanos no perímetro da cidade, em regiões valorizadas e munidas de equipamentos urbanos coletivos, e naquelas a serem valorizadas pela ação pública e/ou privada. Demonstrou-se como a iniciativa privada se apropria dos investimentos públicos para a valorização de seus empreendimentos, o que evidencia a atuação do capital na configuração do ambiente construído. A não aplicação do IPTU progressivo, como um dos instrumentos de cumprimento da função social da propriedade, particularmente no enfrentamento dos vazios urbanos especulativos, demonstra a complexidade dos interesses em jogo. Como o Poder Público municipal vem tratando a questão dos vazios urbanos e do IPTU progressivo na legislação e na prática? Buscou-se compreender alguns aspectos importantes da estrutura e dinâmica do espaço urbano em Campos dos Goytacazes, evidenciando o papel do planejamento urbano, e, neste, reforçar as potencialidades da implementação do IPTU progressivo como meio de reintegrar os vazios urbanos existentes, possibilitando mitigar os impactos da concentração do solo urbano e a especulação imobiliária, fatores agravantes da segregação socioespacial.
A consistência da participação popular em âmbito municipal: revisão do Plano Diretor de Chapecó 2014
Authors: Giacomini Queila De Ramos , Pravatto Tainá , Trzcinski Clarete
Published: September 2018

O artigo tem por objetivo analisar a consistência da participação popular no processo de revisão do Plano Diretor de Chapecó de 2014. Em relação aos procedimentos metodológicos, a pesquisa caracteriza-se como qualitativa do tipo exploratória e descritiva. As fontes foram documentais, a partir da análise de listas de presença das conferências e de atas das audiências públicas da revisão do PDC 2014. A entrevista semiestruturada foi aplicada a uma amostra do tipo intencional para 15 delegados de 10 segmentos que participaram mais ativamente das audiências. A análise dos dados foi realizada a partir de parâmetros de indicadores de consistência da participação popular indicados por Souza (2006), que são: Profundidade decisória da participação; Extensão da participação; Grau de transparência e accountability; Caráter participativo da malha territorial; Inclusividade; Grau de suporte ativo à participação de “grupos vulneráveis”. Os dados mostram que o processo de revisão do Plano Diretor de Chapecó foi participativo. Contudo, observaram-se entraves na participação, pois alguns segmentos organizados participaram mais e defenderam seus interesses, ao passo que a sociedade civil não teve uma participação efetiva em todos os momentos. Conclui-se que a participação na revisão do PDC 2014 se deu de forma parcial.
Kisspeptina en becerras prepúberes: 2. Respuesta de LH, FSH y GH a distintas dosis de kisspeptina-10 y su asociación con IGF-I y leptina circulantes
Authors: Villa Godoy Alejandro , Santos Echeverría Rubén , Rosete Fernández Jorge Víctor , Calderón Robles René Carlos , Perera Marín Gerardo , Arreguín Arevalo Jesús Alejandro , M. Nett Terry
Published: September 2018

En becerras prepúberes, la kisspeptina-10 (KISS-10) estimula la liberación de hormona luteinizante (LH) y hormona foliculoestimulante (FSH), pero su acción en la hormona del crecimiento (GH) es inconsistente. La hipótesis fue que en becerras prepúberes la magnitud de liberación de LH, FSH y GH en respuesta a KISS-10 es determinada por la dosis y las concentraciones endógenas de IGF-I y leptina. Se usaron 20 becerras prepúberes (100-232 kg de peso y 7-11 meses de edad), mismas que recibieron un bolo i.v. de 5 o 50 µg de  KISS-10/kg de peso. Ambas dosis de KISS-10 indujeron un incremento de LH y FSH, más no de GH. La dosis de 50 µg de KISS-10 indujo un área bajo la curva de LH y una duración del incremento de FSH mayores (P<0.05) que la dosis de 5 µg. IGF-I se relacionó negativamente con el aumento de LH en respuesta a la dosis de 50 µg (P<0.05), pero no estuvo asociado con la respuesta de LH a la dosis de 5 µg de KISS-10. La magnitud del incremento de FSH y las concentraciones de GH posteriores a KISS-10 no fueron alteradas por las concentraciones de IGF-I (P>0.05). De la misma forma, las concentraciones de leptina no determinaron (P>0.05) la magnitud del incremento de LH y FSH ni las concentraciones de GH pos tratamiento. En conclusión, la GH no respondió a ninguna dosis, pero la FSH y la LH fueron sensibles al aumento de dosis de KISS-10. Además, la magnitud de respuesta de LH a KISS-10 fue determinada por las concentraciones endógenas de IGF-I, pero no de leptina.
...To Remember Everything
Authors: Lezhava Ilya G.
Published: September 2018

The article is devoted to the problems of mutual influence of Russian and Western architecture. The study covers the period from the XVIII century to the present day. The following stages are considered: the end of the XVII century - the first half of the XIX century; in the XX century - from the 1919 to the 30-ies; further from the 30's to the 50's, from the 50's to the 60's, from the 60's to the 80's and, finally, the period of the beginning of the XXI century. The article is considered by the author not so much as a full-fledged research, but rather as a call to collect new data and publications relating to this topic.
Urban Syntax
Authors: Kolevatykh Dmitry A.
Published: September 2018

The article puts forward the hypothesis of the possible existence of direct and reverse communication between the subject of "city resident" and the object of "urban structure". The features of "urban Language" are considered. The theme of everyday "urban slang" development through the spatial compilation of the city forms is also raised. Some chronological features of the urban Language model formation (archaism and neologism in the context of "urban Language") are revealed. The author introduced new terms describing the phenomena of archetypaLization of urban syntactic forms. The author stresses that the city shouLd be perceived as a deveLoping LinguaL-urban model, a professionaL anaLysis of which provides an opportunity to unveiL current trends in urban development This kind of monitoring wiLL aLLow architects to design reLevant modeLs regarding the existing status of urban deveLopment.
Regularities of the Formation of the City Pedestrian Environment
Authors: Ter-Voskanyan Olga S.
Published: September 2018

The article critically examines the design and construction of pedestrian areas, considering the specifics of transport services in the largest cities of Russia, cultural heritage and scale of modern mobility of the population. It also emphasizes the need to solve the problem of formation of pedestrian streets, adjusting the relevance of the proposed small urban design, without forgetting the main purpose of the street - to ensure the movement of pedestrians. At the same time, it is asserted that the content of the street is a showcase of the actual functional purpose of objects that are placed in a certain place, often with along history, and not a contrived decoration, often out of place borrowed from foreign practice.

In order to identify public opinion about thelatest trends in the organization of pedestrian traffic, a preliminary survey of residents, mainly with children or grandchildren, was conducted, and it showed the failure of the idea of carrying out yard functions on the street for our practice. At the same time, the return of the experience of the XII-XIII centuries, when vehicles were not allowed into the yards and two exits from residential buildings were created: one "front" and the other "black", overlooking the economic yard, helped to solve the modern problem of separation of space for pedestrians and transport.
The Effects of Audit Quality Disclosure on Audit Effort and Investment Efficiency
Authors: Chen Qi , Jiang Xu , Zhang Yun
Published: September 2018

We develop a model to evaluate the costs and benefits of disclosing information about audit quality. Specifically, we examine whether audit quality disclosure affects auditors' effort and investors' investment efficiency. In our setting, an auditor exerts unobservable effort to influence audit quality and is motivated by liability in the event of audit failure. The usefulness of audited financial reports for investors depends on both the quality of the underlying financial reporting (e.g., as embodied by GAAP) and the quality of auditors' reports (i.e., the likelihood with which audit evidence uncovers managerial misreporting). We show that audit quality disclosure increases auditors' effort incentives if and only if the underlying financial reporting quality is relatively weak. We also show that such disclosure can actually reduce investment efficiency. Our analyses contribute to the debate about policies aimed at improving audit transparency.
Do total or partial etching procedures effect the rate of white spot lesion formation? A single-center, randomized, controlled clinical trial
Authors: Yagci Ahmet , Seker Elif Dilara , Demirsoy Kevser Kurt , Ramoglu Sabri Ilhan
Published: September 2018

Objective:

To determine whether total or partial etching procedures influence the appearance of white spot lesions (WSLs).

Materials and Methods:

This split-mouth, double-blind, controlled, randomized study included 20 patients (mean age 16.75 years), who had class I malocclusion, mild crowding, and satisfactory oral hygiene. A total of 40 maxillary quadrants were randomly allocated to be treated using a total etching (TE) or partial etching (PE) protocol. Quantitative light fluorescence images were captured at the beginning and at 3 (T1) and 6 (T2) months after beginning orthodontic treatmen, as well as when the debonding phase of orthodontic treatment was complete (T3). The presence of pre- and posttreatment WSLs was assessed with quantitative light fluorescence software and analyzed with Student's t-test.

Results:

The analyses showed that, at T2, the total etching group had significantly higher ΔQ and A scores than the partial etching group (P < .05). The ΔF scores increased significantly at all timepoints in the TE group, but only at T1 and T3 in the PE group. However, no differences were noted at T3 between the TE and PE groups (P > .05). The inclusion of only right-handed people may have limited the generalizability of the findings. The absence of analyses of the plaque and gingivitis scores of patients was another limitation of this study.

Conclusions:

WSL formation was observed mostly in maxillary lateral incisor teeth irrespective of the etching technique. Although PE seems to be more successful in the first 6 months, no difference was observed between PE and TE in the long term for WSL formation.
Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial
Authors: Morieri Mario Luca , Gao He , Pigeyre Marie , Shah Hetal S. , Sjaarda Jennifer , Mendonca Christine , Hastings Timothy , Buranasupkajorn Patinut , Motsinger-Reif Alison A. , Rotroff Daniel M. , Sigal Ronald J. , Marcovina Santica M. , Kraft Peter , Buse John B. , Wagner Michael J. , Gerstein Hertzel C. , Mychaleckyj Josyf C. , Parè Guillaume , Doria Alessandro
Published: September 2018

OBJECTIVE

We evaluated whether the increasing number of genetic loci for coronary artery disease (CAD) identified in the general population could be used to predict the risk of major CAD events (MCE) among participants with type 2 diabetes at high cardiovascular risk.

RESEARCH DESIGN AND METHODS

A weighted genetic risk score (GRS) derived from 204 variants representative of all the 160 CAD loci identified in the general population as of December 2017 was calculated in 5,360 and 1,931 white participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) and Outcome Reduction With Initial Glargine Intervention (ORIGIN) studies, respectively. The association between GRS and MCE (combining fatal CAD events, nonfatal myocardial infarction, and unstable angina) was assessed by Cox proportional hazards regression.

RESULTS

The GRS was associated with MCE risk in both ACCORD and ORIGIN (hazard ratio [HR] per SD 1.27, 95% CI 1.18–1.37, P = 4 × 10−10, and HR per SD 1.35, 95% CI 1.16–1.58, P = 2 × 10−4, respectively). This association was independent from interventions tested in the trials and persisted, though attenuated, after adjustment for classic cardiovascular risk predictors. Adding the GRS to clinical predictors improved incident MCE risk classification (relative integrated discrimination improvement +8%, P = 7 × 10−4). The performance of this GRS was superior to that of GRS based on the smaller number of CAD loci available in previous years.

CONCLUSIONS

When combined into a GRS, CAD loci identified in the general population are associated with CAD also in type 2 diabetes. This GRS provides a significant improvement in the ability to correctly predict future MCE, which may increase further with the discovery of new CAD loci.
Performance Evaluation of Stocks’ Valuation Models at MSE
Authors: Ivanovski Zoran , Narasanov Zoran , Ivanovska Nadica
Published: September 2018

Subject and purpose of work: The main task of this paper is to examine the proximity of valuations generated by different valuation models to stock prices in order to investigate their reliability at Macedonian Stock Exchange (MSE) and to present alternative “scenario” methodology for discounted free cash flow to firm valuation. Materials and methods: By using publicly available data from MSE we are calculating stock prices with three stock valuation models: Discounted Free Cash Flow, Dividend Discount and Relative Valuation. Results: The evaluation of performance of three stock valuation models at the MSE identified that model of Price Multiplies (P/E and other profitability ratios) offer reliable stock values determination and lower level of price errors compared with the average stocks market prices. Conclusions: The Discounted Free Cash Flow (DCF) model provides values close to average market prices, while Dividend Discount (DDM) valuation model generally mispriced stocks at MSE. We suggest the use of DCF model combined with relative valuation models for accurate stocks’ values calculation at MSE.
Wellness Tourism and Non-Productive Function of Forests
Authors: Szymańska Elżbieta , Kalejta Joanna
Published: September 2018

Subject and purpose of work: The research problem is wellness tourism and its connections with forest economy. The main goal is to determine the mutual connections occurring between wellness tourism and forest economy. Materials and methods: The research was carried out in three stages using various methods: a comparative analysis of 39 spas, standardised inspections of facilities offering health tourism services and the selection of a facility being a model of good practice (case study). Results: The most important forms of the small tourist infrastructure offered to patients in forest areas are hiking and bicycle paths (92%), as well as horse trails and viewing points (about 50%). Cluster initiatives and cooperation with local governments and forest districts, consisting in joint promotion, are important. A diagram was developed, showing the interactions of forest economy and wellness tourism. Conclusions: Providers of spa services and State Forests are natural partners, yet the level of cooperation is low and mainly involves promotional activities. It is advisable to create a nationwide forest and sanatorium spa organisation that would coordinate activities in the field of forest economy to take advantage of tourism and health-promoting assets of forests.
QUALITY CONTROL ANALYSIS WITH SIX SIGMA-DMAIC METHOD IN EFFORT REDUCE NUMBER OF SUGAR PRODUCTS AT PT. PG. GORONTALO
Authors: Kartini Ida Ayu Nuh , Syarief Dwi Jayanthi
Published: September 2018

Companies need to maintain and improve the quality of products derived by applying a good quality control, because quality is an important factor in improving satisfaction and loyalityas consumers, as well as PT. PG .Gorontalo ; Six Sigma methods that have high discipline can help develop and deliver near-perfect products. The purpose of this study was to determine how the value of sigma PT .PG . Gorontalo and what factors of product defects. In this analyzis , researchers took 3 months of data production and analyze the Six Sigma DMAIC method. Researchers examined / analyzed using a questionnaire and the report of production to help get the material of analyzis. From this research , it has been showed that the presence of defects of products in the production process of PT. PG. Gorontalo at 5.664, 72 DPMO. It is also known that the cause is the human factor , machines, methods, materials, and environment. Based on these results , we can conclude that the value of sigma PT. PG. Gorontalo is located at 4 to 4.5 sigma, the factor most dominant cause of disability is due to lack of proper vacuum pressure
SOCIAL INTERPRETATION OF “WAJAH OTT” IN POLITICAL COMMUNICATION MANAGEMENT CONTEXT OF PAUL RICOUER ANALYSIS (HAND CATCH OPERATION KPK -“OTT’S FACE”)
Authors: Sumartias Suwandi , Amina Nurtyasih Wibawanti Ratna
Published: September 2018

The writing purpose to understand and criticize Social Text "Facial OTT (The Face of Hand Catch Operation "KPK (Corruption Eradication Commission). Using research method “Hermeneutic Analysis of Paul Ricouer”, it seeks to understand behind the text as representation and  multi-interpretation. The results showed that two heads of areas whose  gotthe KPK ‘s Hand Catch Operation (OTT), Jambi Governor and West Bandung Regent were "smiling" in front of journalistscoverage. Facial expression (non-verbal communication) of human has a very closely related with its attitude, thoughts and behavior. Body language (especially, facial expression) is an inseparable representation of what is in the mind and heart.  “Wajah OTT” as an important part of language, signs, and symbols and representations require fundamental and comprehensive interpretation. The social interpretation of the smiling of “OTT's face” is increasingly asserted as a representation of the existence of space-time, experience and reference (history) and culture of society, which are mutually related and inseparable. Recommendation, as long as we do not intend or dare to open the meaning behind the social "mask" on the text of "OTT's face" itself through understanding as "the way " and or the "being" of the whole human being as dasein (its history, ideals and habits), so corruption will forever be part of the culture of society.
SELECTION OF Coffea arabica L. HYBRIDS USING MIXED MODELS WITH DIFFERENT STRUCTURES OF VARIANCE-COVARIANCE MATRICES
Authors: Pereira Fernanda Aparecida Castro , Carvalho Samuel Pereira de , Rezende Tiago Teruel , Oliveira Leonardo Luiz , Maia Diego Rosa Baquião
Published: September 2018

This study aimed to evaluate different structures of variance-covariance matrices in modeling of productive performance of coffee genotypes over the years, and select hybrids of Coffea arabica using mixed models. A mixed linear model was used to estimate variance components, heritability coefficients, and prediction of genetic values of hybrids and cultivars. Three commercial cultivars and eight hybrids of C. arabica L. were evaluated. The field production after acclimatization of seedlings was conducted in March 2006. The yield averages from 2009, 2010, 2011, 2013, and 2014 agricultural years were evaluated. The selection criteria of models were used to test 10 structures of variance-covariance matrices, and later a model was chosen to estimate the components of variance, heritability coefficients, and prediction of genetic values. According to Bayesian information criterion (BIC), the best structure was ARMA (Autoregressive Moving Average); however, considering the Akaike Information Criterion (AIC) and corrected Akaike Information Criterion (AICC), the CSH (Heterogeneous Composite Symmetric) was indicated. The Spearman correlation between the genotypic values obtained in the models with ARMA and CSH type R matrix was 0.84. The high and positive correlation indicates that the best model could involve the R matrix with ARMA or CSH structure. The heritability of individual genotypes differed from heritability in broad sense, which considers the independence among agricultural years. Hybrids with higher performance were identified by ordering the genotypic effects, among them, H 2.2, H 4.2, and H 6.1 hybrids were highlighted.
SPATIAL VARIABILITY OF SOIL PENETRATION RESISTANCE IN COFFEE GROWING
Authors: Andrade Alan Delon , Faria Rafael De Oliveira , Alonso Diego José Carvalho , Ferraz Gabriel Araújo e Silva , Herrera Miguel Angel Diaz , Silva Fábio Moreira da
Published: September 2018

The intensive use of machines in agriculture tends to cause soil compaction, which can hamper the expansion of root system and the absorption of water and nutrients, thus affecting the crop development. In view of the above, the present study aimed to identify critical zones of soil compaction, through the spatial distribution of soil penetration resistance (SPR), having positions within the coffee rows and soil depth ranges as variables. The study was performed in a coffee plantation of 7.32 ha, belonging to the Bom Jardim Farm, located in the municipality of Bom Sucesso, MG, Brazil. The SPR was measured using a penetrometer in the depth range from 0 to 0.40 m, with discretization in four layers of 0.10 m. The data were interpreted based on geostatistics, in order to identify if there is spatial dependence of the SPR and generate thematic maps demonstrating the variable’s spatial behavior. It is concluded that there is spatial dependence of soil penetration resistance, being possible to use geostatistical tools to generate thematic maps based on classes of soil penetration resistance. The values of SPR in the tractor trail, for layers from 0.10 to 0.20 and from 0.20 to 0.30 m, were classified in the high SPR class and could cause damage to the crop.
Synergistic Action of Copper Catalysts and Lewis Acids in Carbon–Carbon Bond Forming Reactions
Authors: Das Manas , Harutyunyan Syuzanna
Published: September 2018

Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C–C bond forming reactions. In this review we will discuss
various examples where the application of this strategy provides access to efficient catalytic processes for the synthesis of chiral molecules such as alcohols, amides and heteroarenes.
Critérios de utilização do Facebook como instrumento de interação social: estudo comparativo em bibliotecas universitárias nacionais e internacionais
Authors: Macedo Andrielle Gomes , Lins Greyciane Souza
Published: September 2018

A pesquisa tem por objetivo o estudo da implantação e das perspectivas de uso das mídias sociais por bibliotecas universitárias do Brasil, Estados Unidos e Inglaterra. Visa analisar os desafios e possibilidades na utilização dessas tecnologias para a realização das atividades nas bibliotecas, comparando as práticas de interação social com os usuários. Os procedimentos metodológicos se caracterizam pela análise e descrição dos perfis de nove bibliotecas na rede social Facebook, sendo três delas situadas nos Estados Unidos da América, três no Brasil e três na Inglaterra. Trata-se de um estudo de natureza descritiva com amostras não probabilísticas e por conveniência, com o uso dos métodos comparativo e indutivo por pesquisa de campo e a coleta de dados quanti-qualitativa por observação. Os resultados foram obtidos através de análise descritiva a partir de buscas aplicadas nas mídias sociais, identificando por meio de critérios estabelecidos, as informações e os conteúdos disponibilizados nessas plataformas. Conclui que a implantação dessas ferramentas em bibliotecas universitárias traz benefícios para suas atividades, mas requer planejamento e monitoramento constantes em prol da melhoria eficiente e eficaz na prestação de produtos e serviços, bem como no atendimento aos usuários mediante as possibilidades de comunicação e interação oferecidas por essas plataformas.
Quem está preservando seus dados digitais? Estaria surgindo uma nova profissão?
Authors: Boeres Sonia Araújo de Assis
Published: September 2018

A quantidade da informação digital tem aumentado exponencialmente cada vez mais, e sua preservação digital é imperativa, sob o risco de perdas irreparáveis para pessoas, sociedades e organizações. Nomes como ‘coordenador de recursos eletrônicos’, ‘gestor de serviços digitais’, ‘curador de dados’ e outros estão aparecendo na literatura, e em anúncios de emprego, para designar o profissional da informação que está desenvolvendo a tarefa da preservação digital. Por que o título ‘profissional da informação’ não está mais sendo suficiente para caracterizar quem tem desenvolvido esta tarefa? Talvez uma nova profissão esteja se configurando. Por isto, baseado em revisão da literatura, este artigo se propõe a investigar como surge uma profissão e quais as competências que este “novo” profissional da informação deve ter para desempenhar a tarefa de preservar e curar conteúdos digitais. Conclui-se mostrando que estes procedimentos pressupõem um conjunto de profissionais, com múltiplas formações e competências, e que atuarão em diferentes áreas e estágios no processo de preservação e curadoria dos dados digitais.
Políticas E Tecnologias De Preservação Digital No Arquivamento Da Web
Authors: Rockembach Moises , Pavão Caterina Marta Groposo
Published: September 2018

O objetivo do artigo foi analisar a preservação digital a partir da abordagem de arquivamento da web, desde as tecnologias envolvidas no processo de arquivamento, bem como políticas de seleção, preservação e disponibilização destes conteúdos, além do estudo de instituições internacionais que atuam na preservação da web. A metodologia utiliza pesquisa bibliográfica e documental sobre iniciativas internacionais de arquivamento da web e objetiva fomentar a discussão no Brasil, assim como servir de subsídio para estudos aplicados. Analisa as publicações científicas na base de periódicos Scopus dos últimos cinco anos (2012-2016) que versam sobre o arquivamento da web, políticas de seleção dos conteúdos web e tecnologias aplicadas à coleta, armazenamento e acesso aos websites arquivados. Traz também um panorama das tecnologias utilizadas pela comunidade de iniciativas de arquivamento da web, a partir da identificação dos dados disponibilizados no site do Consórcio Internacional de Preservação da Internet. Conclui que países que ainda não possuem iniciativas próprias, como o Brasil, com o estabelecimento de políticas de seleção com enfoques específicos (institucionais, temáticas, por domínio, etc.), assim como uma gestão do ciclo de vida do arquivamento da web e a adoção de tecnologias no formato código aberto (open source) podem não só preservar sua memória digital, mas também contribuir com a comunidade internacional de arquivamento da web.
Brasília e a memória em registros digitais: traços da paisagem e a preservação de dados
Authors: Tavares Maria de Fátima Duarte , Arellano Miguel Mardero , Nakagomi Bruno
Published: September 2018

A gestão de dados de pesquisa, em paralelo à disponibilidade pública e informatizada de coleções científicas, contempla a emergência do problema da organização do conhecimento e do reuso de dados digitais. Neste estudo de caso, está em foco o tratamento de dados reutilizados, considerando a problematização de seu acesso futuro e estratégias de preservação digital em longo prazo. O processo de investigação, em análise, está relacionado à urbanização do território do Distrito Federal, após a implantação de Brasília, em contraposição à formação de uma memória científica local. O quadro espaço-temporal, entre 1960 a 2016, visa identificar campos de saber em construção, seus agentes e suas inter-relações a partir de séries de registros visuais, dados populacionais, cartográficos e coleções botânicas. Essas fontes estão sujeitas a políticas de acesso e de disseminação distintas, que colocam restrições ao segundo ciclo de vida dessa documentação. O reuso de dados de coleções científicas, vinculadas ao Cerrado no Distrito Federal, foi orientado por metodologia histórico-geográfica e foi objeto de requalificação analítica, com suporte de um sistema de informações geográficas. Os resultados de mapeamento em cartas temáticas podem ser visualizados na plataforma digital Dataverse, tendo em vista garantir acesso, reuso e preservação digital.
Percepções da importância da preservação digital
Authors: Faria Juliana Pinheiro , Araújo Luiza Martins de Santana , Evangelista Raimunda Lima
Published: September 2018

A proposta deste estudo é demonstrar as diferentes concepções das diversas áreas de conhecimento que estão aplicando recursos da preservação digital, além de salientar a dimensão da importância de pesquisas na área para que novas rotinas e estratégias sejam desenvolvidas e implementadas. Este estudo ainda revela o crescimento da preservação digital na Rede Cariniana com o uso do LOCKKS, possibilitando melhor auxílio às necessidades de seus parceiros e promovendo a melhoria dos serviços da Rede, bem como a implementação de novos produtos. Foi aplicado um questionário do tipo survey a fim de verificar as atuais demandas, dificuldades e práticas empregadas pelas instituições parceiras da Cariniana. Constata-se que apesar das instituições parceiras considerarem as práticas de preservação digital muito importante em seu meio, ainda falta apoio institucional e elaboração de critérios para desenvolvimento de políticas que padronizem e possibilitem a continuidade de seus serviços.
Iniciativas científicas de arquivamento e preservação de conteúdos em mídias sociais: panorama atual
Authors: Rezende Laura Vilela Rodrigues , Martins Dalton Lopes
Published: September 2018

O estudo realiza um mapeamento de experiências científicas que realizam coleta e arquivamento de conteúdos de mídias sociais. Apresenta inicialmente um breve referencial teórico relacionado à preservação digital e Web 2.0. Pesquisa de abordagem qualitativa e de cunho exploratório uma vez que buscou identificar nas experiências inovadoras questões pouco investigadas, tais como as características: tecnológicas (plataforma de mídia social utilizada, solução tecnológica utilizada para a coleta dos dados e formato de armazenamento dos dados coletados); e contextuais verificando se os metadados garantem proveniência, autenticidade e como é a gestão de direitos e tipos de acesso aos dados. Os resultados apontam que, embora o foco principal destas iniciativas não seja diretamente a preservação, esta questão está intrinsecamente contemplada. O Twitter é a plataforma principal de coleta de dados utilizada por pesquisadores. Vários são os desafios elencados, é preciso especificar como e por quem os dados coletados serão utilizados e relevante deve ser a atuação curatorial nestes projetos, visando selecionar o que de fato deve ser guardado. Por fim, as restrições das plataformas de mídias sociais e a falta de transparência e compreensão sobre suas práticas de gestão de dados atualmente dificultam a preservação deste tipo de conteúdo.
Preservação digital de documentos arquivísticos e o Projeto de Lei 7.920/2017 sob a ótica da Ciência da Informação
Authors: Hott Daniela Francescutti Martins , Cruz-Riascos Sonia Aguiar
Published: September 2018

Esta pesquisa tem por finalidade discutir a proposta do Projeto de Lei nº 7.920/2017, que dispõe sobre a digitalização de documentos, destacando a importância da preservação digital, a partir de pareceres especializados de profissionais arquivistas do Brasil. Identifica os aspectos pertinentes à gestão arquivística de documentos digitais na administração pública no país, com foco para a digitalização de documentos a partir de normatizações. Aponta as diretrizes gerais do Conselho Nacional de Arquivos (CONARQ) quanto Ã  preservação digital de documentos arquivísticos e as principais ações desenvolvidas por esse órgão. Utiliza como procedimentos metodológicos o levantamento bibliográfico e a pesquisa documental na Câmara dos Deputados e no CONARQ, bem como a técnica do discurso do sujeito coletivo para a consolidação de parte dos pareceres logrados por meio de coleta virtual. Entre os resultados, destaca-se que 93% dos respondentes são favoráveis ao arquivamento da referida proposta do Projeto de Lei, tendo ocorrido apenas uma abstenção. Em suma, a pesquisa oferece subsídios para a ampliação dos debates na área em prol da construção de políticas de informação com enfoque na preservação digital de documentos arquivísticos trazendo benefícios tanto para os órgãos da administração pública quanto para a sociedade brasileira.