bluuebunny/crossref_metadata_2025 huggingface dataset:
A new updated prognostic index for patients with brain metastases (BM) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project
Authors: Flores-Paco Pablo , Vargas Alicia , Guevara María Geraldina , Lopera Ignacio , Ruiz Lucía Rodríguez , López-Herrero María , Camús Juan Adrián , López-González Javier , Inga-Saavedra Isabel II , Montero Marina , Barneto Isidoro , Gómez María Auxiliadora , Ruiz Estela , Ruza Marta , Armenta Ana , Palacios Amalia , Haba-Rodríguez Juan de la , Aranda Enrique
Published: February 2024

Introduction
Palliative WBRT is the main treatment for multiple BM. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strategies based on targeted therapies are improving the prognosis of patients with BM. The purpose of this study is to develop a prognostic score in palliative pts with BM who undergo WBRT in this new setting.
Methods
239 pts with BM who received palliative WBRT between 2013–2022 in our center were analyzed retrospectively. The score was designed according to the value of the β coefficient of each variable with statistical significance in the multivariate model using Cox regression. Once the score was established, a comparison was performed according to Kaplan-Meier and was analyzed by log-rank test.
Results:
149 pts (62.3%) were male and median (m) age was 60 years. 139 (58,2%) were lung cancer and 35 (14,6%) breast cancer. All patients received 30Gys in 10 sessions. m overall survival (OS) was 3,74 months (ms). 37 pts (15,5%) had a specific target mutation. We found that 62 pts were in group < 4 points with mOS 6,89ms (CI 95% 3,18 − 10,62), 84 in group 4–7 points with mOS 4,01ms (CI 95% 3,40 − 4,62) and 92 pts in group > 7 points with mOS 2,72ms (CI 95% 1,93 − 3,52) (p < 0,001).
Conclusions:
METASNCore items are associated with OS and they could be useful to select palliative pts to receive WBRT. More studies are necessary to corroborate our findings.
THE PANDEMIC CHALLENGES FOR TRADITIONAL COMMUNITIES AT THE CROSS-BORDER POST AREAS OF THE REPUBLIC OF INDONESIA-PAPUA NEW GUINEA
Authors:   Faculty of Social and Political Science, Pelita Harapan University, MH Thamrin Boulevard 1100, Kelapa Dua, Tangerang, Banten 15811, Indonesia, Tambunan Edwin Martua Bangun , Lantang Floranesia ,   Faculty of Social and Political Science, Pelita Harapan University, MH Thamrin Boulevard 1100, Kelapa Dua, Tangerang, Banten 15811, Indonesia
Published: February 2024

The COVID-19 pandemic has posed a threat to the border area of the Republic of Indonesia-Papua New Guinea (RI-PNG). To prevent the spread of the virus, both countries closed border posts and border markets in January 2020. This article aims to analyse the challenges faced by traditional communities in Indonesia who share cultures and traditions with their counterparts in Papua New Guinea and are used to crossing borders without restraint before the pandemic. From the view of community security, the emergence of COVID-19 in the border areas of the RI-PNG is a threat to people in the vicinity. The closure of cross-border posts and border markets has implications for native Papuan communities, affecting their ability to maintain their traditional relationships and values. Through qualitative descriptive research using field study as a research method, primary data were collected through interviews, supplemented with secondary data from library research. This research reveals that the closure of cross-border posts and border markets has disrupted the sustainability of culture, traditions, kinship, and traditional economic activities among traditional communities in the border area. Dissatisfied with the lockdown imposed by the Indonesian and Papua New Guinean governments, the traditional border crossers took advantage of illegal routes to continue their traditional activities. However, they were also very concerned about cross-border criminals exploiting the same track. A growing concern was emerging that the security measures implemented to safeguard citizens during the pandemic would persist, thereby hindering the restoration of traditional cross-border movement to normal conditions.
WHY DO MIDDLE POWERS PROJECT FORCES IN DISTANT REGIONS? THE CASE OF FRANCE IN THE INDO-PACIFIC
Authors:   College of Social Sciences, Department of Political Science, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea, Kerdodé Christophe , Motin Dylan ,   College of Social Sciences, Department of Political Science, Kangwon National University, 1 Gangwondaehakgil, Chuncheon-si, Gangwon-do 24341, Republic of Korea
Published: February 2024

France has steadily increased its military presence in the Indo-Pacific region in recent years. However, a middle power projecting forces far away represents an anomaly for neorealism, which generally expects non-great power states to focus their limited resources on their regional neighbourhood. This article proposes a new neorealist framework to explain why middle powers sometimes intervene in distant regions and tests it on the French case. Such interventions are likely if four conditions are met. First, the middle power must live in a relatively safe neighbourhood. Second, the distant region of interest must be open to power projection. Third, this region must have a potential hegemon that threatens to overturn the local balance of power. Fourth, economic benefits must offset the middle power’s cost of projecting forces there. This study helps explain French policy in the Indo-Pacific, fills a gap in neorealist theorising, and contributes to the literature on middle-power behaviour.
DIVERGENT OUTCOMES FOR DEMOCRACY FROM RECENT ELECTIONS IN FIJI AND THE MALDIVES: ANALYSING THE 2018 ELECTIONS AND ITS AFTERMATH
Authors:   Department of Ethics and Governance, Fiji National University, Derrick Campus, Ratu Mara Road, Samabula, Fiji, Bhim Mosmi
Published: February 2024

This paper examines the historical background and conduct of recent elections in two small island nations in Asia-Pacific, Fiji and the Maldives. It assesses the situation of democracy prior to elections, and afterwards in 2020–2021. This paper seeks to contribute towards filling the gap in literature, with regards to comparative case studies on electoral authoritarianism in small island states. The two nations with dissimilar history, religion, ethnicity and geology, held national elections in 2018. Fiji comprising volcanic and limestone islands with a multiethnic and multi-religious population is located in the Pacific Ocean. The Maldives with lowest lying coral atolls, and a homogeneous population of one ethnicity and one religion Islam, is located in the Indian Ocean. The elections were conducted under differing circumstances of electoral authoritarian rule in the aftermath of multiparty elections, with repression in the Maldives increasing, and repression in Fiji easing. But the 2018 election results saw a return to transition to democracy in the Maldives. Conversely in Fiji, the electoral authoritarian government was re-elected. Challenges to democracy remained unchanged in both nations during the COVID-19 pandemic.
The Relationship among Perceptions of Green HRM, Green Work Climate, Employee Green Motivation, and Environmental Commitment: The Case of Bangladesh Textile Industry
Authors:   Human Engagement Institute, Akter Afroza , Lee Hyuneung
Published: February 2024

As global concerns about environmental degradation and climate change intensify, green human resource management (GHRM) has emerged as a crucial strategic approach for organizations that are recognizing the need to align their human resource practices with sustainable, eco-friendly initiatives. In this study, it is proposed that GHRM affects employees’ environmental commitment by fostering a green work climate and enhancing their green motivation. To gather empirical evidence for this proposition, the researchers collected data from 201 Bangladeshi employees working in the textile industry, and conducted statistical analysis using structural equation modeling (SEM). The findings of the study are as follows: First, perceptions of GHRM had significant positive relationships with both perceived green work climate and employee green motivation. Second, perceived green work climate did not have a significant relationship with employee green motivation controlling for perceptions of GHRM. Third, both perceived green work climate and employee green motivation had positive relationships with environmental commitment. Fourth, both perceived green work climate and employee green motivation had significant mediating effects on the GHRM-environmental commitment relationship. Implications and suggestions are presented based on these findings.
Les adolescents et les devoirs à la maison : représentations, pratiques, et place du numérique
Authors: Schneider Élisabeth , Guichon Nicolas
Published: February 2024

Les devoirs à la maison sont une activité ordinaire des adolescents élèves et sont représentatifs de la permanence de la forme scolaire. Afin de repérer les enjeux actuels en particulier liés au développement des usages du numérique éducatif, une enquête auprès d’adolescents en France cherche à mettre en évidence les dimensions spatiale, culturelle, symbolique et cognitive des devoirs prescrits par les enseignants. L’analyse des discours montre le désarroi des élèves et la perte de sens d’une activité pourtant au cœur de l’activité scolaire.
Adaptasi Nuansa Lokal pada Proses Perancangan Bangunan Komersial di Bali
Authors: Gabriella Jessica Caroline , Leonara Celza , Raniasta Yohanes Satyayoga
Published: February 2024

Title: The Adaptation of Local Architecture in the Commercial Building Design Process in Bali

The local Balinese architecture is still being developed and maintained simultaneously in Bali, incorporating elements of history and space. Over time, modernization has impacted the existence of local Balinese architecture in its manifestation. The local government responded to the act of preserving culture by establishing a Bali Regional Regulation, which regulates the design of architectural buildings with local Balinese nuances. The existence of this culture has become the main attraction in Bali, and it requires support from the spaces or commercial buildings. Therefore, the image of commercial buildings is regarded as a manifestation of the existence of local Balinese architectural culture. This paper focuses on the building's appearance, with two object location points as the case study to determine how to adapt local nuances to different typologies, namely Pahdi Coffee Kintamani and Benoa Beach Club, as objects that can illustrate the process of design acculturation. The research evaluated the design against existing benchmarks to obtain the adaptation process used in commercial building design. The method used was qualitative descriptive. As a result, the design of Pahdi Coffee Kintamani and Benoa Beach Club can fit with the function needed and adapt the local Balinese architecture through the appropriate process.
RESISTANCE SERIE DANS LA PHOTOPILE BIFACIALE (N+/P/P+) AU SILICIUM SOUS CHAMP MAGNETIQUE : EFFET DE LA RESONANCE EN TEMPERATURE DU COEFFICIENT DE DIFFUSION
Authors:   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal., Sow Ousmane ,   Institut Universitaire de Technologie. Universite Iba Der THIAM de ThiÃ¨s-Senegal., Diop Abdoulaye ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal., Loum Khady ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal.,   Institut Universitaire de Technologie. Universite Iba Der THIAM de ThiÃ¨s-Senegal., Traore Youssou ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal.,   Institut Universitaire de Technologie. Universite Iba Der THIAM de ThiÃ¨s-Senegal., Gueye Sega ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal.,   Faculte des Sciences et Technologies de Leducation et de la Formation-Departement de Physique et Chimie, Universite Cheikh Anta DIOP, Dakar-Senegal., Thiame Moustapha ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal.,   Universite Assane SECK, Ziguinchor, Senegal., Sissoko Gregoire ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal.
Published: February 2024

Dans ce travail, laccent est mis sur letude de la caracteristique densite de courant - tension, obtenue de la photopile sous eclairement, en lien avec la vitesse de recombinaison des porteurs minoritaires de charge a la jonction, pour differentes valeurs de lepaisseur optimum obtenue pour chaque valeur du coefficient de diffusion optimum. Le paramÃ¨tre electrique quest la resistance serie est alors deduit et etudie en fonction de la vitesse de recombinaison des porteurs minoritaires de charge a la jonction, imposant le point de fonctionnement a la photopile depaisseur optimum de la base induite par le coefficient de diffusion maximum.
EFFECTIVENESS OF ULTRASOUND GUIDED PLATELET RICH PLASMA INJECTION IN COMPARISON WITH EXTRACORPOREAL SHOCK WAVE THERAPY ON IMPROVING PAIN AND FUNCTION IN PATELLAR TENDINOPATHY: A RANDOMIZED CONTROLLED TRIAL
Authors: Adarsh Singh Sagolsem , Joy Singh Akoijam , Ningthemba Singh Yumnam , Bhupes Pheiroijam , Nandabir Singh Yumnam , Purnimala Kongkham , Sobhasini Devi Laimujam , R. Ramkumar
Published: February 2024

Background: Patellar Tendinopathy is an insertional tendinopathy of the extensor apparatus of the knee that affect athletes practicing several sports at every level of participation but is found mainly in elite athletes involved in jumping activities. The characteristic complaint is an anterior knee pain with insidious onset, localized in the involved area. Diagnosis is clinical and is typically based on medical history and clinical findings. Many methods to treat Patellar Tendinopathy have been evaluated, and there is no true consensus on the most efficacious treatment strategy. Objectives: To determine the effectiveness of ultrasound guided platelet rich plasma injection in comparison with extracorporeal shock wave therapy on improving pain and function among athletes with Patellar Tendinopathy. Study Design: Randomized controlled trial Methods: Forty-four athletes with patellar tendinopathy meeting the inclusion and exclusion criteria were selected for this study and randomized into 2 treatment groups: autologous PRP injections under ultrasound guidance (PRP group n = 22), and 3 sessions of focused extracorporeal shock wave therapy (ESWT group n = 22). The outcome measures were Victorian Institute of Sports Assessmentâ€“Patella (VISA-P) questionnaire and pain visual analog scale (VAS). For descriptive statistics mean, standard deviation and frequency were used. Continuous variables were analysed by students t-test. Categorical variables were analysed using Chi-square test. Within the group comparison (baseline and follow-up data of each group) was done by Repeated measures ANOVA. Between the groups comparison was analysed using students t-test. A p-value <0.05 was taken as significant. Results: The 2 groups were homogeneous in terms of their baseline characteristics like age, gender, duration of symptoms and side of affection. Within group comparison showed statistically significant improvement in VISA-P score and reduction in VAS from baseline at all follow ups (p=0.00) in the PRP group. While in the ESWT group, maximum improvement was seen from baseline to 1st follow up at 4 weeks (p = 0.01). However subsequent follow up showed reduction in VISA-P Scores and increased VAS but remained above the baseline values and it was statistically significant (p < 0.05) (Table III). Conclusion: Ultrasound guided injection of platelet rich plasma lead to significant improvement in pain and function over the long term in comparison with focused ESWT in the treatment of patellar tendinopathy in athletes and thereby enabling faster return to sports.
UNVEILING THE DYNAMICS: EXPLORING POLICE TRAINEES FIELD TRAINING EXPERIENCES IN THE CORDILLERA REGION
Authors:   Graduate School of Criminal Justice and Public Safety, University of Baguio., Alfran Depayso Floresca Denmar
Published: February 2024

The Field Training Program involved the experience and assignment in patrol, traffic, and investigation in the police stations as active observers and passive performers. With this, the study aimed to determine the experiences of the Philippine National Police Field Training Program trainees of Cordillera. Specifically, it investigated the learning experiences of the Field Training Program trainees in Investigation, Traffic, and Patrol and common problems encountered by FTP during their Field Training Program. A qualitative descriptive design was used for the inquiry. Data collection involved using an interview guide. 70 Police Trainees from the Cordillera Administrative Region Training Center. Most of the key informants stated that the major learnings they have acquired during their assignment at the Investigation unit include the proper way to accomplish the blotter entry and incident report form, the Basic Process of Crime Investigation, how to make basic investigation reports, and modes of filing criminal cases. On their duty at the Traffic Management Unit, the police trainees learned how to conduct traffic direction and control effectively. They learned the value or importance of courtesy, discipline, and maximum tolerance when directing, controlling, and managing traffic and how to engage the members of the community effectively. Another is that police trainees have learned the importance of police visibility relative to crime prevention. The common problems encountered by FTP trainees during their Field Training Program include Unclear and conflicting Instructions, lack of equipment for mobility in responding to police assistance or incidents, the lack of enhancement lectures and table tap exercises rendered to police trainees on OJT is another challenge encountered and Lack of Communication and Coordination among trainees.
PSEUDOMYXOMA PERITONEI SECONDARY TO A VERY RARE OVARIAN CANCER: PRIMARY INFILTRATIVE INTESTINAL TYPE MUCINOUS ADENOCARCINOMA OF THE OVARY WITH INTESTINAL METASTASIS (A CASE REPORT)
Authors:   Department of Gynecology - Obstetrics II, Hassan II Teaching Hospital, Fez., Krite Saloua , Zohra Alaoui Fdili Fatima ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Ngawa Ngalande Edith ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Jayi Sophia ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Belhaj Yassine ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Chaara Hikmat ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Abdelah Melhouf Moulay ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Tahiri Elousrouti Layla ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez., Bentayeb Rafik ,   Department of Anatomopathology Science, Hassan II Teaching Hospital, Fez.
Published: February 2024

Pseudomyxoma peritonei (PMP) syndrome is a disease that typically occurs from ruptured appendiceal mucocele neoplasms. PMP syndrome may arise from malignant transformation of a primary ovarian cancer. In this case study, we present the evaluation and treatment of a 48-year-old patient diagnosed with a left ovarian mass and significant symptomatic abdominopelvic mucinous ascites. Peritoneal cytology indicated paucicellularmucin. The final diagnosis confirmed the presence of diffuse peritoneal adenomucinosis. The treatment approach involved a cytoreductive surgery and chemotherapy. Our findings contribute to the existing body of literature endorsing the use of this intensive treatment approach, typically reserved for advanced abdominal malignancies. We applied this strategy to a patient presenting with a rare clinical entity, further supporting its efficacy in such cases.
SPATIO-TEMPORAL DYNAMICS OF ARSENIC CONTAMINATION OF SEDIMENTS IN IVORIAN COASTAL LAGOONS: THE CASE OF THE ABY LAGOON SYSTEM (ABYNORTH, TENDO)
Authors:   Departement des Sciences Analytiques et Sante Publiques, UFR des Sciences Pharmaceutiques et Biologiques -Universite Felix HouphouÃ«t-Boigny, Cote dIvoire., Stephane Jean Claon , Mbassidje Arsene Seka ,   Laboratoire des Sciences de lEnvironnement (LSE), Universite Nangui Abrogoua, Abidjan, Cote dIvoire., Kouakou Serge Kouassi ,   Laboratoire de Biologie et Sante, Universite Felix HouphouÃ«t-Boigny, Abidjan, Cote dIvoire., Aminata Bakayoko ,   Departement des Sciences Analytiques et Sante Publiques, UFR des Sciences Pharmaceutiques et Biologiques -Universite Felix HouphouÃ«t-Boigny, Cote dIvoire., Guei Jokebed Dakouo ,   Departement des Sciences Analytiques et Sante Publiques, UFR des Sciences Pharmaceutiques et Biologiques -Universite Felix HouphouÃ«t-Boigny, Cote dIvoire., Joseph Djaman ,   Departement de Biochimie Medicale et Fondamentale, Institut Pasteur de Cote dIvoire, Abidjan, Cote dIvoire., Luc Philippe Kouadio ,   Departement des Sciences Analytiques et Sante Publiques, UFR des Sciences Pharmaceutiques et Biologiques -Universite Felix HouphouÃ«t-Boigny, Cote dIvoire.
Published: February 2024

Arsenic present in various components of lagoon ecosystems. This study aims at characterizing its distribution and identifying the factors influencing its mobility and bioavailability. Sediment samples were collected, prepared, and analyzed according to standardized protocols. Arsenic concentrations, measured by ICP-MS, were subjected to statistical analyses (ANOVA, t-test, correlation, etc.). The results revealed significant variability in arsenic concentrations in the sediments of the studied lagoons, with averages ranging from 9.13 mg/g in Tanoe lagoon to 27.16 mg/g in the bays of Tendo lagoon. They also showed seasonal and spatial variations in arsenic contamination, linked to the hydrological, geological and anthropogenic conditions of each site. Significant correlations were found between arsenic concentrations and environmental parameters such as salinity, transparency, conductivity and pH. These results contribute to a better understanding of the processes governing arsenic dynamics in coastal lagoons and underline the importance of considering seasonal variations and environmental conditions in sediment contamination studies.
WOOLY HAIR PALMOPLANTAR KERATODERMA : A CASE REPORT
Authors:   Final Year Postgraduate, Department of DVL, Narayana Medical College, Nellore 524003., Gayathri Dantham , Kiran Raja Uday ,   Assistant Professor, Department of DVL, Narayana Medical College, Nellore 524003., Vijaya Mohan Rao A ,   Professor and Head of Department, Department of DVL, Narayana Medical College, Nellore 524003.
Published: February 2024

Wooly hair is a rare hair shaft abnormality characterized by extremely curly hair. It can occur in isolation or associated with palmoplantar keratoderma (PPK) and cardiac defects. We present the case of a 56-year-old female patient who initially presented with non-itchy, painful skin lesions over palms and soles since 5years and had abnormal scalp hair texture since childhood. She responded positively to treatment with topical application of 6%salicylic acid twice a day for 3 months on which the thickness and size of the plaques gradually reduced.
Time Series Forecasting Approach for Predictive Modeling of Next Menstrual Cycle Length
Authors: Oliveira Paulina Julia , Cavalcante Caio , Rego Rosana
Published: February 2024

A proper forecast of the menstrual cycle is meaningful for women’s health, as it allows individuals to take preventive actions to minimize cycle-associated discomforts. In addition, precise prediction can be useful for planning important events in a woman’s life, such as family planning. In this work, we explored the use of machine learning techniques to predict regular and irregular menstrual cycles. We implemented some time series forecasting algorithm approaches, such as AutoRegressive Integrated Moving Average, Huber Regression, Lasso Regression, Orthogonal Matching Pursuit, and Long Short-Term Memory Network. Moreover, we generated synthetic data to achieve our purposes. The results showed that it is possible to accurately predict the onset and duration of menstrual cycles using machine learning techniques.
Agricultural drought response to meteorological drought over different agro-climatic zones of the Ganga River basin
Authors: C.V. Anjali , Pachore Akshay , Remesan Renji
Published: February 2024

Drought directly impacts the agricultural ecosystem, thus causing significant threat to regional and global food security. Investigating the occurrence and propagation patterns of drought events is crucial for its better understanding and mitigation. The study investigates different agro-climatic regions of the Ganga River basin from 2001 to 2020 to quantify meteorological drought using the Standardized Precipitation Index (SPI). Additionally, the assessment of agricultural drought was conducted using the Standardized Soil Moisture Index (SSMI) and Normalized Difference Vegetation Index (NDVI). For understanding the propagation dynamics of drought, Pearson Correlation Coefficient (PCC)-based approach was employed to compute the propagation time between meteorological and agricultural drought types. Stronger correlations were observed between SPI and SSMI compared to SPI and NDVI anomaly, highlighting the direct connection between precipitation and soil moisture. The results of the present study show that the time for propagation ranges within 1–11 months across the Ganga basin as inferred from the maximum PCC values between the SPI and SSMI time series. The propagation rate from meteorological drought to agricultural drought varied from 29.03 to 73.33% among different agro-climatic regions. The insights gained from this analysis on propagation time and rate can inform policymakers in formulating appropriate measure.
Strengthening rural community water safety planning in Pacific Island countries: evidence and lessons from Solomon Islands, Vanuatu, and Fiji
Authors: Souter Regina T. , Ruuska Doug , Pene Sarah , Benjamin Collin , Funubo Sheila , Beal Cara D. , Sanderson Rosanna , Batikawai Suliasi , Ravai Ana , Antoinette-Wickham Tema , Rankin Tom , Peter Lindah , Molitambe Heather , Theophile Gaston , Shrestha Sachita , Kotra Krishna K. , Bugoro Hugo , Panda Nixon , Deo Vimal , Love Mark
Published: February 2024

Pacific Island Countries (PICs) collectively have the lowest rates of access to safely managed or basic drinking water and sanitation globally. They are also the least urbanised, have dynamic socioeconomic and increasing climate-linked challenges. Community-based water managers need to respond to variability in water availability and quality caused by a range of hazards. Water Safety Planning (WSP), a widely adopted approach to assessing water supply, offers a risk-based approach to mitigating both existing and future hazards. WSP is adaptable, and making modifications to prescribed WSP to adapt it to the local context is common practice. Within the Pacific Community Water Management Plus research project, we used formative research and co-development processes to understand existing local modifications, whether further modifications are required, and, to develop additional modifications to WSP in Fiji, Vanuatu and Solomon Islands. The types of additional local modifications we recommend reflect the unique context of PICs, including adjusting for community management of water supplies and required collective action, community governance systems, levels of social cohesion in communities, and preferred adult-learning pedagogies. Incorporating modifications that address these factors into future WSP will improve the likelihood of sustained and safe community water services in Pacific and similar contexts.
Progress of evapotranspiration research based on VOSviewer: A review
Authors: Yang Zetian , Qin Tianling , Wang Huiliang
Published: February 2024

Evapotranspiration (ET) is a key link between atmospheric processes and land surface hydrological processes. With the impact of global warming and human activities, research on ET has become a hot topic. Supported by a total of 1,222 Chinese and English literatures from China National Knowledge Infrastructure and the Web of Science Core Collection from 2013 to 2022, this paper adopts the bibliometric visualization method to review the current research progress and future trend of ET with respect to the time of publication, countries, institutions, journals, and research hotspots. The results show that the number of related research articles is increasing rapidly and the journals with high citations are Journal of Hydrology, Agricultural and Forest Meteorology and Agricultural Water Management. The research hotspots have been focused on prototype observation, remote sensing inversion, mechanism equation, model simulation, spatial–temporal analysis, and attribution identification. In the future, there is an urgent need to integrate algorithms such as machine learning and artificial intelligence, to develop higher resolution remote sensing products, to improve the mechanism equations based on precise observations, and to clarify the impact of synergistic effects on ET among the driving factors.
Research Progress of PD 1/PD L1 Inhibitors in the Treatment of
Urological Tumors
Authors: Han Lv , Meng Yang , Jianguo Zhu
Published: February 2024

:

Immune checkpoint inhibitors (ICIs) offer significant advantages for the treatment of
urologic tumors, enhancing the immune function of anti-tumor T cells by inhibiting PD-1 and PDL1
binding. They have been shown to be well tolerated and remarkably effective in clinical practice,
offering hope to many patients who are not well treated with conventional drugs. Clinical
trials in recent years have shown that anti-PD-1 and PD-L1 antibodies have good efficacy and safety
in the treatment of urologic tumors. These antibodies can be applied to a variety of urologic tumors,
such as bladder cancer, renal cell carcinoma, and prostate cancer. They have been approved
for the first-line treatment or as an option for follow-up therapy. By blocking the PD-1/PD-L1 signaling
pathway, ICIs can release immune functions that are suppressed by tumor cells and enhance
T-cell killing, thereby inhibiting tumor growth and metastasis. This therapeutic approach
has achieved encouraging efficacy and improved survival for many patients. Although ICIs have
shown remarkable results in the treatment of urologic tumors, some problems remain, such as
drug resistance and adverse effects in some patients. Therefore, further studies remain important
to optimize treatment strategies and improve clinical response in patients. In conclusion,
PD-1/PD-L1 signaling pathway blockers have important research advances for the treatment of
urologic tumors. Their emergence brings new hope for patients who have poor outcomes with traditional
drug therapy and provides new options for immunotherapy of urologic tumors. The purpose
of this article is to review the research progress of PD-1 and PD-L1 signaling pathway blockers
in urologic tumors in recent years.
Role of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Prevention, Diagnosis, and Treatment of Gastrointestinal Cancers
Authors: Ghorbani Fereshte , Mazidimoradi Afrooz , Biyabani Arezou , Allahqoli Leila , Salehiniya Hamid
Published: February 2024

:

Most cancer deaths are related to gastrointestinal (GI) cancers. Several environmental
and genetic factors are effective in the occurrence of GI cancers, such as esophageal, stomach, colorectal,
liver, and pancreatic cancers. In addition to risk factors related to lifestyle, reactive oxygen
species (ROS) also play a role in GI cancers, and an increase in the amount of free radicals
can lead to oxidative stress and increase the probability of malignancies. NQO1 is part of the
body's antioxidant defense system that protects cells against mutagenesis and carcinogenesis.
NQO1 is responsible for reducing quinones to hydroquinone and preventing the generation of
ROS by catalyzing the reaction. The existence of single nucleotide polymorphisms (SNPs) of
NADPH Quinone Reductase 1 (NQO1), such as 609C>T NQO1, leads to a decrease in NQO1 enzyme
activity. Some NQO1 polymorphisms may increase the risk of gastrointestinal cancer. So,
the C609T polymorphism in the NQO1 gene has been found to be effective in causing gastrointestinal
cancers. On the other hand, it is very important to know the role of biomarkers in the prognosis
and management of cancer treatment. Therefore, this study investigated the role of NQO1 as
a biomarker in the management of gastrointestinal cancers (prevention, diagnosis and treatment).
Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants:
An Update
Authors: Choudhary Diksha , Kaur Rajwinder , Singh Thakur Gurjeet , Kumar Bhupinder
Published: February 2024

Depression is one of the key conditions addressed by the Mental Health Gap Action
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is associated
with low levels of neurotransmitters, which eventually play a key role in the progression and development
of mental illness. The nitrogen-containing heterocyclic compounds exhibit the most
prominent pharmacological profile as antidepressants. Pyrazoline, a dihydro derivative of pyrazole,
is a well-known five-membered heterocyclic moiety that exhibits a broad spectrum of biological
activities. Many researchers have reported pyrazoline scaffold-containing molecules as
potential antidepressant agents with selectivity for monoamine oxidase enzyme (MAO) isoforms.
Several studies indicated a better affinity of pyrazoline-based moiety as (monoamine oxidase inhibitors)
MAOIs. In this review, we have focused on the recent advancements (2019-2023) in the
development of pyrazoline-containing derivatives exhibiting promising inhibition of MAO-A enzyme
to treat depression. This review provides structural insights on pyrazoline-based molecules
along with their SAR analysis, in silico exploration of binding interactions between pyrazoline
derivatives and MAO-A enzyme, and clinical trial status of various drug molecules against depression.
The in-silico exploration of potent pyrazoline derivatives at the active site of the MAOA
enzyme will provide further insights into the development of new potential MAO-A inhibitors
for the treatment of depression.
Insight into the Natural Biomolecules (BMs): Promising Candidates as
Zika Virus Inhibitors
Authors: Dobhal Kiran , Garg Ruchika , Singh Alka , Semwal Amit
Published: February 2024

Zika virus (ZIKV) is among the relatively new infectious disease threats that include
SARS-CoV2, coronavirus, monkeypox (Mpox) virus, etc. ZIKV has been reported to cause severe
health risks to the fetus. To date, satisfactory treatment is still not available for the treatment
of ZIKV infection. This review examines the last five years of work using natural biomolecules
(BMs) to counteract the ZIKV through virtual screening and in vitro investigations. Virtual
screening has identified doramectin, pinocembrin, hesperidins, epigallocatechin gallate,
pedalitin, and quercetin as potentially active versus ZIKV infection. In vitro, testing has shown
that nordihydroguaiaretic acid, mefloquine, isoquercitrin, glycyrrhetinic acid, patentiflorin-A,
rottlerin, and harringtonine can reduce ZIKV infections in cell lines. However, in vivo, testing is
limited, fortunately, emetine, rottlerin, patentiflorin-A, and lycorine have shown in vivo anti-
ZIKV potential. This review focuses on natural biomolecules that show a particularly high selective
index (>10). There is limited in vivo and clinical trial data for natural BMs, which needs to
be an active area of investigation. This review aims to compile the known reference data and
discuss the barriers associated with discovering and using natural BM agents to control ZIKV
infection.
A Comparative Analysis of Feature Selection Algorithms in Cross Domain
Sentiment Classification
Authors: Goel Lipika , Gupta Sonam , Gupta Avdhesh , Nandal Neha , Rajan Siddhi Nath , Gupta Pradeep
Published: February 2024

Background:

Cross-domain Sentiment Classification is a well-researched field in
sentiment analysis. The biggest challenge in CDSC arises from the differences in domains and
features, which cause a decrease in model performance when applying source domain features
to predict sentiment in the target domain. To address this challenge, several feature selection
methods can be employed to identify the most relevant features for training and testing in
CDSC.

Method:

The primary objective of this study is to perform a comparative analysis of different
feature selection methods on the various CDSC tasks. In this study, statistical test-based feature
selection methods using 18 classifiers for the CDSC task has been implemented. The impact
of these feature selection methods on Amazon product reviews, specifically those in the
DVD, Electronics, Kitchen, and TV domains, has been compared. Total 12x18 experiments
were conducted for each feature selection method by varying source and target domain pairs
from the Amazon product reviews dataset and by using 18 classifiers. Performance evaluation
measures are accuracy and f-score.

Results:

From the experiments, it has been inferred that the CSDC task depends on various factors
for a good performance, from the right domain selection to the right feature selection
method. We have concluded that the best training dataset is Electronics as it gives more precise
results while testing in either domain selected for our study.

Conclusion:

Cross-domain sentiment analysis is a dynamic and interdisciplinary field that offers
valuable insights for understanding how sentiment varies across different domains.
Grid Search based Optimum Feature Selection by Tuning hyperparameters for Heart Disease Diagnosis in Machine learning
Authors: Saranya G. , Pravin A.
Published: February 2024

Background:

Heart disease prediction model helps physicians to identify patients who are at high risk of developing heart disease and target prevention strategies accordingly. These models use patient demographics, medical history, lifecycle factors, and clinical measurements to calculate the risk of heart disease within a certain time frame. In identifying important features of heart disease, a popular approach is using Machine learning (ML) models. ML models can analyse a large amount of data and find patterns that are difficult for humans to detect.

Methods:

In this proposed work, Random Forest classifier is used to identify the most important features that contribute to heart disease and increase the prediction accuracy of the model by tuning the hyperparameters using grid search approach.

Results:

The proposed system was evaluated and compared in terms of accuracy, error rate and recall with the traditional system. As the traditional system achieved accuracies between 81.97% and 90.16%., the proposed hyperparameter tuning model achieved accuracies in the range increased between 84.22% and 96.53%.

Conclusion:

These evaluations demonstrated that the proposed prediction approach is capable of achieving more accurate results compared with the traditional approach in predicting heart disease by finding optimum features.
Paradigma Positivisme Hukum John Austin Di Era Posmodernisme
Authors: Setiawan Adam , Ismail Rezky Robiatul Aisyiah
Published: February 2024

The purpose of this research is to find out how the legal positivism paradigm of John Austin in the era of postmodernism and explain the relevance of legal positivism in law enforcement in Indonesia. This research uses method of philosophy of law. The results are that John Austin's legal positivism paradigm in the era of postmodernism is increasingly losing its way because it is exclusive. The legal positivism paradigm cannot be a guidance in law because the shortcomings of the legal positivism paradigm include the legal positivism paradigm constructed by Austin that is unable to accommodate important aspects outside the specified elements such as ethical, moral, and religious elements. Although, the paradigm of legal positivism in Indonesia has become the main point of law enforcement because of the continental European legal tradition. However, in practice the legal positivism paradigm is not compatible with the existing legal patterns in Indonesia because: (1) Indonesian society is heterogeneous; (2) Social, political, and economic developments are transforming so rapidly that the law is lagging behind; and (3) Indonesian people are religious but have no absolute ideology of religion.
Morphological characterization of extrafloral nectaries in Brazilian Amazonian plant species
Authors: Nakayama Miranda Patrícia , Lahoz da Silva Ribeiro José Eduardo , Aguirre-Jaimes Armando , Brasil Izaias , Dáttilo Wesley
Published: February 2024

Background and Aims: Extrafloral nectaries (EFNs) are secretory glands of an aqueous solution composed mainly of sugars, amino acids and lipids, frequently used as food resource by ants, which tend to protect their host plants against herbivorous insects. Although the Amazon forest is recognized worldwide for its high plant diversity, few studies have been carried out in the region that characterize the different morphotypes of EFNs. In this context, our main aim was to perform a brief morphological description of EFNs in the Brazilian Amazonian rainforest.
Methods: We established a plot of 6250 m2 in ten forest fragments situated in the state of Acre, Brazilian Amazon. In these plots, we performed intensive field surveys to locate EFN-bearing plant species. Subsequently, we used scanning electron microscopy images to morphologically characterize the EFNs. The morphological descriptions included information about the life form of EFN-bearing plant species, morphotypes of EFNs and their location in different plant structures.
Key results: We morphologically characterized 67 EFN-bearing plant species, distributed in 28 genera and 19 families. The botanical families with the highest taxonomic representativeness were Fabaceae, Bignoniaceae and Malpighiaceae. Lianas were the life form with the largest number of EFN-bearing plant species, while elevated EFNs were the most frequent morphotype.
Conclusions: The high frequency of elevated EFNs evidences the importance of the ant defense system against herbivory in these Brazilian Amazonian forests, since it has been documented in others works that this morphotype secretes a larger nectar volume, which is an advantage in relation to the attraction potential. Finally, our results indicate the existence of a high diversity of EFN-bearing plant species in this region of the Brazilian Amazon, and an important morphological diversity of associated extrafloral nectaries.
The effectiveness of flipbook-based e-modules in increasing student creativity in nail art subject in higher education
Authors: Rahmiati Rahmiati , Putri Mutia , Engkizar Engkizar , Mokhtar Marzni Mohamed
Published: February 2024

Incorporating technology into the learning process has resulted in the development of various new media for lecturers to use in delivering subject matter. Furthermore, the material presented is intended to enable students to develop creative and innovative ideas in higher education vocational majors in makeup and beauty. The purpose of this study is to determine how effective the flipbook-based module is in increasing student creativity in nail art subject at the Department of Beauty and Cosmetology at Universitas Negeri Padang. This study employs a quantitative and experimental approach (Group Pretest-Posttest Design). Data were collected from thirty respondents using a Likert scale questionnaire and a pre-test and post-test of nail art practice skills. All respondents are students in the Department of Cosmetology and Beauty, Faculty of Tourism and Hospitality, for the 2021/2022 academic year. All data were then analyzed descriptively and correlated using SPSS 23 software. Overall, the analysis results showed that using flip book-based e-modules could increase students' creativity in nail art subjects. These results can be proven by the effectiveness test of students' creativity, with an average value of 71.9%. Furthermore, the correlation analysis revealed a significant value of 0.05 and a t-score of 7.083 t-table of 2.045. The results of this study imply that it can provide references for education in choosing learning media and strategies for delivering learning materials that are effective in increasing creativity. Furthermore, this can be used as a basis for further development to produce effective media and learning approaches.
Revealing the characteristics of Indonesian language test used in the national-standardized school examinations
Authors: Ulwatunnisa Marwah , Retnawati Heri , Muhardis Muhardis , Yusron Eri
Published: February 2024

This study aimed to determine the characteristics of Indonesian language test used in the national standardized school examinations (Ujian Sekolah Berstandar Nasional, USBN). We used the response data of 218 students from a public senior high school in the Special Region of Yogyakarta, Indonesia, to the test consisting of two packages, A and B, in the 2018/2019 academic year to investigate the characteristics of the test and its items. Quantitative analysis using classical test theory (CTT) and one-parameter logistic item response theory (1-PL IRT) model was conducted to investigate the characteristics of the test and its items based on difficulty and discriminating power. The results of the study under the CTT showed that most test items in both package A and package B have difficulty in the easy category and the portion of items in the difficult category is no more than 10%. In addition, while the majority of test items in both test packages demonstrated good discriminating power, package B contained a high number of items with poor discriminating power (47.5%). Under 1-PL IRT, our study results indicated the dominance of items with difficulty level in the moderate category in both test packages. In addition to revealing the difficulty level of the test items, our study showed that the items in the difficult category under CTT and IRT were related to the topics of types of conjunction; spelling, grammar, and sentence structure; job application letter; and observation report text and its structure. The results of this study are expected to contribute to improving the quality of the Indonesian language test and the quality of learning on topics where students have difficulty based on test items in the difficult category.