bluuebunny/crossref_metadata_2025 huggingface dataset:
Possible health benefits of polyphenols in neurological disorders associated with COVID-19
Authors: Olaleye Oladele , Titilope Oladele , Moses Oyeleke
Published: November 2021

Novel Coronavirus disease 2019 (COVID-19) represents an emergent global health burden that has challenged the health systems worldwide. Since its sudden upsurge in 2019, many COVID-19 patients have exhibited neurological symptoms and complications. Till now, there is no known effective established drug against the highly contagious COVID-19 infection despite the frightening associated mortality rate. This article aims to present the mechanism of action of coronavirus-2 (SARS-CoV-2), the clinical neurological manifestations displayed by COVID-19 patients, and present polyphenols with neuroprotective ability that can offer beneficial effects against COVID-19-mediated neuropathology. Reports from COVID-19 clinical studies, case reports, and other related literature were evaluated for this review. Neurological complications of COVID-19 include anosmia, acute cerebrovascular disease, acute disseminated post-infectious encephalomyelitis, encephalitis, etc. Also, SARS-CoV-2 sould be a neurotropic vіruѕ due to its iѕolatіon from serebroѕrіnal fluіd. Multіrle neurologіsal damages displayed by COVID-19 patients might be due to hyperinflammation associated with SARS-CoV-2 infections. Resveratrol, kolaviron, quercetin and apigenin are polyphenols with proven anti-inflammatory and therapeutic properties that can extenuate the adverse effects of COVID-19. These polyphenols have been documented to suppress c-Jun N-terminal kinase (JNK), phosphoinositide-3-kinase (PI3-K), extrasellularѕіgnal-regulated kinase (ERK), nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-kB) and mіtogen-astіvated protein kіnaѕe (MAPK) pathways which are essential in the pathogenesis of COVID-19. They also showed significant inhibitory activities against SARS-CoV-2 proteins. Taken together, these polyphenols may offer neuroprotective benefits against COVID-19 mediated neuropathology via modulation of the pathogenic pathways.
Effectiveness of Tocilizumab after switching from intravenous to subcutaneous formulation in patients with rheumatoid arthritis: A single-centre experience
Authors: Stojanović Sonja , Stamenković Bojana , Nedović Jovan , Aleksić Ivana , Cvetković Jovana
Published: November 2021

Nowadays, the appropriate control of rheumatoid arthritis (RA) involves the absence of clinical disease activity, delaying joint destruction as long as possible and adequate quality of life of the affected. With currently available therapeutic modalities, this therapeutic goal can be achieved in a large number of patients. The aim of this research was to determine the effectiveness of an IL-6 blocker (Tocilizumab) in patients with RA in everyday clinical practice. We also analyzed whether a change in the mode of drug administration (switching from intravenous to subcutaneous drug formulation) had an impact on drug effectiveness (using the DAS 28 SE and CDAI indexes) and quality of life of patients with RA (HAQ, Beck Depression Inventory, FACIT F score and SF 36 questionnaire). The study included 53 subjects diagnosed with RA, treated with Tocilizumab. After a six-month use of subcutaneous Tocilizumab, we concluded that the method of drug administration did not have an impact on its effectiveness and on all the examined parameters of quality of life assessment.
Testing of portfolio optimization through investments in stock market indices and Bitcoin
Authors: Grujić Miloš , Mekinjić Boško , Vujičić-Stefanović Dragana
Published: November 2021

This paper presents an empirical verification of the effectiveness and usefulness of investment diversification using the main stock exchange indices and Bitcoin. The objective is to determine the effects applying the Markowitz portfolio optimization theory, i.e., the advantages of applying the modern portfolio theory for institutional investors. The research offers an answer to the following question: what are the advantages and disadvantages of using Bitcoin in portfolio optimization? The paper contributes to the representation of the reach and limitations of the modern portfolio theory for institutional investors. The conclusion is that rational behaviour of institutional investors requires consideration of portfolio optimization using the Markowitz model, because it is possible to create portfolios which, on the basis of historical returns, provide desired returns alongside certain risks. The methodology includes the analysis of high frequency data, i.e., daily trading data were used. The results indicate that the use of the Markowitz portfolio selection method, with all its limitations, is desirable, possible and applicable, but that it entails serious flaws in the sense of neglecting transaction costs, foreign exchange differences and the real value in the stock market. The results of the research show that Bitcoin is a good source of diversification in a portfolio that contains traditional financial instruments both for the risk-averse investor as well as for those investors who have a greater appetite for risk. The conclusion is that rational behavior of institutional investors requires consideration of investing in Bitcoin using the Markowitz model. However, given the high degree of volatility, investors should be very careful when making decisions about including Bitcoin in the portfolio.
An empirical study of the work conditions and productive performance after collaborative robotics implementation in a manufacturing assembly process
Authors: Colim Ana , Morgado Rita , Dinis-Carvalho José , Sousa Nuno
Published: November 2021

Industry 4.0 has led to a widespread and impactful evolution of technology that is transforming industry and organizations in general. Collaborative robotics is considered one of the new features in this movement allowing humans and robots to work together in perfect collaboration. This paper presents the implementation of one collaborative robot in an assembly process and analyses its impact on performance and ergonomic work conditions. In terms of ergonomic conditions, the musculoskeletal risk was assessed, comparing both processes (without and with robotics support). The results demonstrated that collaborative robotics is a solution that allows improving the ergonomic work conditions throughout the assembly process.
Investigation of running-in process based on surface roughness parameters, real contact area ratio and tribological properties
Authors: Horng Jeng-Haur , Biswas Dipto , Adhitya A , Ahsan Qumrul
Published: November 2021

The running-in process is the initial process for the new moving parts wearing against each other to establish the shape adjustment that will regulate them into a stable relationship for the rest of their working life. The objective of this research is to investigate and evaluate the running-in process by using disk-on-block line contact device. Due to its empirical nature and well-ploughed analysis, an asperity micro-contact model is considered. The experiment is performed by varying the surface roughness of the block with rigid smooth sphere surface under specific condition. The effects of surface roughness, load, speed, and lubrication on the running-in behaviour is studied. The running-in process encourage plastic deformation of asperities and created microstructural changes on contact surfaces. The theoretical and experiment result shows that the plasticity index ps, surface roughness parameter b, real contact area ratio * A0 and specific film thickness l is influenced by the running-in process.
Theoretical and experimental studies on the cut zone generated by AWJ process
Authors: Patirnac I. , Ripeanu R.G. , Ramadan I.N.
Published: November 2021

The aim of this paper is to make a theoretical and experimental study to evaluate the water jet influence on a metallic material used in oilfield manufacturing, using AWJ process. It was investigated how the scattering of the jet has influenced the width of the kerf and neighboring area. The metallic material is P275NL2 which is a low temperature quality steel alloy specially used in petrochemical industry. The experimental tests were made on the waterjet cutting machine model YCWJ-380-1520 using preestablish working conditions. Theoretical investigations were performed using CFD simulation with planar 2D fluid flow on the geometrical model. Graphical correlation was performed between theoretical outcomes given by CFD simulation and experimental results on the regarded material, overlapping on the theoretical searching for the cutting velocity and the hardening velocity limits nearby the kerf.
The role of pharmacists in crisis management and humanitarian missions: Current state and perspectives
Authors: Zaklan Dragana , Imrek Rastislava , Pavlović Nebojša , Todorović Nemanja , Lalić-Popović Mladena , Goločorbin-Kon Svetlana
Published: November 2021

According to the World Disasters Report from 2018, 3,751 natural disasters occurred in previous ten years, which affected 2 billion people, and according to the United Nations report, 134 million people required help. COVID-19 pandemic revealed the unpreparedness of humanity for the global catastrophe, and in the first six months of the pandemic, 50 million people faced the consequences of more than a hundred disasters classified as catastrophes. In this paper we aimed to determine which competencies of pharmacists are necessary, as well as to analyze existing and possible options of pharmacists' involvement in the healthcare team, as well as pharmacists' contribution to the healthcare system in crisis situations. In crisis situations, the pharmacist, in addition to traditional, performs a wide range of non-traditional activities. They include drug and medical device supply management, participation in providing emergency medical care, patient care, supervision of therapy, immunization, but also in establishing crisis management policy and implementing adopted principles. The involvement of pharmacists in humanitarian work is still insufficient, although progress has been made. The COVID-19 pandemic has certainly opened a new chapter in the development of pharmaceutical profession, which will certainly significantly change after the current crisis, along with other professions. Active involvement of pharmacists in healthcare teams is necessary in order to optimally use their expertise, and they themselves to gain experience. In future, this would enable the formation of good practice standards and improving the outcomes of humanitarian or public health missions.
Assessment of information and health habits of patients with diabetes mellitus
Authors: Savić Nikola , Lukić Igor , Mitrović Jelena , Jokić Zoran , Ružičić Dušan , Zlatanović Milena
Published: November 2021

Objective. Diabetes mellitus is a chronic disease in which the body either does not produce or inadequately uses the hormone of the pancreas, insulin. Health education work with this population of patients is an important aspect of treatment and health care, it aims to change harmful health behavior and prevent complications. The aim of the research is to examine the information and health habits of patients with diabetes mellitus, to determine the presence of factors that can affect the worsening of the condition and lead to complications of the disease. Methods. The research was conducted according to the type of cross-sectional study. To collect data, a questionnaire for patients with diabetes mellitus was used, which the authors constructed for this research. The research was conducted in the population of patients with diabetes, in the period June-August 2018. at the General Hospital in Valjevo. The sample consisted of 110 respondents. Results. In the observed sample, almost 2/3 (63%) of the respondents are overweight, and almost 3/4 (74%) of the respondents regularly control their blood sugar values. More than 1/2 (56%) were educated for glycemic self-control, 70% were informed about signs of hyperglycemia, 87% were signs of hypoglycemia. More than 1/3 of respondents are exclusively on insulin therapy, 87% adhere to the therapeutic regimen, 87% of the subjects are trained for insulin self-application. 90% of respondents go to check-ups regularly, and 97% think that the information they receive from health workers is useful. Conclusion. Healthcare professionals of all profiles, primarily doctors and nurses, should continuously conduct health education work with people with diabetes. The largest number of patients in the observed sample were informed about their disease and hygienic dietary regime. In order to make the results even more encouraging, it is necessary to intensify health education work at all levels of health care.
Influence of the dimensions of service quality, customer satisfaction and behavioural intentions on the respective constructs in retail banking: The Middle East context
Authors: Sangeetha Jaya
Published: November 2021

Present competitive environment has made it necessary for organizations today to measure and monitoring service quality, customer satisfaction and behavioural intentions. Research is required to provide input to practicing managers to make appropriate organizational strategies towards customer retention and organizational excellence. This paper aims to study the influence of the dimensions on the respective constructs in the retail banking industry to get insights for strategy formulation that can help optimize utilization of the limited resources available for deployment. A robust procedure was used to develop the scale for the three constructs which would be appropriate for the culture and the country context. The scale obtained consisted of 7 dimensions for service quality and customer satisfaction, and 3 dimensions for behavioural intentions. The analysis of the data obtained from 373 usable questionnaires revealed that security and the other 'outcome' dimensions are the most important regarding service quality and customer satisfaction. In behavioural intentions, Loyalty was found to be the most important.
Emergency management in the Republic of Serbia during the Covid-19
Authors: Štrbac Katarina , Tomić Duško
Published: November 2021

For the first time in the history of humanity, the world encountered a global emergency that showed all the weaknesses of emergency management and the unwillingness of states to respond to that challenge adequately. Although it is evident that the governments in which the state-owned health care system adapted more quickly to the epidemic, it was also apparent that the emergency management was practically on local governments, but also that the states with a clearly defined legal framework and established management systems emergencies are easier to deal with such an emergency. In the Republic of Serbia, there is a legally prescribed procedure for acting in epidemics, which is a sufficient basis for engaging emergency management. The organizational challenges of the epidemic are practically the responsibility of local self-government units, and so far, although the epidemic is still ongoing, according to available data, it seems that they are adequately responding to that challenge. This paper is based on the legal framework analysis for introducing the state of emergency and the practical research of the engagement of local self-governments during the epidemic.
HYEON, K. et al. Veritable Records of the Joseon Dynasty (조선왕조실록). Instituto Nacional de Historia de Corea.
Authors: González Pons Alberto
Published: November 2021

Corea del Sur cuenta ya con una trayectoria larga en el campo de las Humanidades Digitales y, aunque las primeras iniciativas no se concebían como producción intelectual con proyección exterior, a principios del siglo XXI esto comienza a cambiar y surgen proyectos como el Veritable Records of the Joseon Dynasty (조선왕조실록). Se trata de un proyecto oficial gestionado por el Gobierno Surcoreano en el que se pone a disposición pública los más de 2000 libros que componen los Anales de la Dinastía Joseon, recogidos entre los siglos XV y XIX. Este proyecto representa un ejemplo claro de transversalidad dentro de las Humanidades Digitales, con un público objetivo variado e ideado para tener un impacto generalizado, lejos de convertirse en una fuente de información restringida o incluso desconocida para aquellos individuos que puedan mostrar interés por los Anales de la Dinastía Joseon.
Las ediciones digitales de PROLOPE: entre la edición digital y la edición digitalizada
Authors: Mateos Frühbeck Nicolás
Published: November 2021

El concepto de edición digital sigue siendo una incógnita en la evolución de las Humanidades Digitales. Todavía no hay consenso sobre qué parámetros deben formar parte de dichas ediciones, lo que conlleva una libertad en el uso del concepto que está dando lugar a híbridos y a “pseudoediciones” digitales demasiado diferenciadas entre sí. El proyecto PROLOPE, entre muchos otros, consta de algunas ediciones de esta índole en su biblioteca digital, entre las que se encuentran La dama boba y Mujeres y Criados de Lope de Vega, ambas denominadas “ediciones digitales”, aun cuando la distancia entre una y otra parezca muy acusada. En este trabajo se describirán y se evaluarán las funcionalidades de estas dos ediciones “digitales”, y se concluirá con una teoría de cara al futuro la ecdótica en el plano digital.
Una introducción a los estudios de atribución de autoría en el ámbito disciplinario de la Lingüística Forense y al programa de análisis de textos ALTXA
Authors: Latorre García Juan Antonio
Published: November 2021

RESUMEN
Este artículo presenta un caso de atribución de autoría en el ámbito de la lingüística forense a partir de la herramienta ALTXA. Primeramente, se aportará una definición general de la lingüística forense y una breve explicación de sus principales áreas de estudio con el propósito de acotar progresivamente el foco de la investigación hasta llegar a los estudios de atribución de autoría, los cuales serán abordados con mayor profundidad. En segundo lugar, el artículo evaluará las principales herramientas computacionales empleadas para determinar de forma cuantitativa la autoría de textos anónimos o disputados y presentará el software ALTXA, el cual ha sido creado por el presente grupo investigador. Dicha herramienta computacional pretende aunar las funcionalidades de distintos programas informáticos en una interfaz accesible que permita la implementación de los estudios de atribución de autoría en contextos educativos y facilite la labor del lingüista forense. El artículo concluirá con una demostración práctica de ALTXA en la que se realizará un estudio de atribución de autoría de un fragmento indubitado de William Shakespeare para demostrar la validez del programa, así como de los estudios de n-grams, una de las funcionalidades que ofrece dicha herramienta y que constituyen un procedimiento metodológico consolidado en el campo de la lingüística forense.
PALABRAS CLAVE
Lingüística forense, lingüística computacional, atribución de autoría, William Shakespeare, n-grams.
ABSTRACT

This article will present a case of authorship attribution within the framework of forensic linguistics with the computational tool ALTXA. For such end, a general definition of forensic linguistics and an explanation of its main areas of study will be offered with the aim of narrowing down progressively the scope of the article until authorship attribution studies are presented and discussed in more depth. Afterwards, a review of the main computational tools with which the authorship of disputed or anonymous texts are analysed will be provided, and ALTXA, a software that has been developed by the researcher, will be presented. Such tool combines many of the functionalities offered by other programs in an intuitive interface that allows for the implementation of authorship attribution studies in educational settings and facilitates the labour of the forensic linguist. Lastly, the article will provide a practical demonstration of ALTXA in which the authorship of an undisputed text written by William Shakespeare will be analysed to prove its reliability. Such analysis will consist of an n-gram study, which is one of the functionalities of ALTXA and constitutes a solid methodological procedure within the framework of forensic linguistics.
KEYWORDS
Forensic linguistics, computational linguistics, authorship attribution, William Shakespeare, n-grams.
SOURCE: Prediction Models for Overall Survival in Patients With Metastatic and Potentially Curable Esophageal and Gastric Cancer
Authors: van den Boorn Héctor G. , Abu-Hanna Ameen , Haj Mohammad Nadia , Hulshof Maarten C.C.M. , Gisbertz Suzanne S. , Klarenbeek Bastiaan R. , Slingerland Marije , Beerepoot Laurens V. , Rozema Tom , Sprangers Mirjam A.G. , Verhoeven Rob H.A. , van Oijen Martijn G.H. , Zwinderman Koos H. , van Laarhoven Hanneke W.M.
Published: November 2021

Background: Personalized prediction of treatment outcomes can aid patients with cancer when deciding on treatment options. Existing prediction models for esophageal and gastric cancer, however, have mostly been developed for survival prediction after surgery (ie, when treatment has already been completed). Furthermore, prediction models for patients with metastatic cancer are scarce. The aim of this study was to develop prediction models of overall survival at diagnosis for patients with potentially curable and metastatic esophageal and gastric cancer (the SOURCE study). Methods: Data from 13,080 patients with esophageal or gastric cancer diagnosed in 2015 through 2018 were retrieved from the prospective Netherlands Cancer Registry. Four Cox proportional hazards regression models were created for patients with potentially curable and metastatic esophageal or gastric cancer. Predictors, including treatment type, were selected using the Akaike information criterion. The models were validated with temporal cross-validation on their C-index and calibration. Results: The validated model’s C-index was 0.78 for potentially curable gastric cancer and 0.80 for potentially curable esophageal cancer. For the metastatic models, the c-indices were 0.72 and 0.73 for esophageal and gastric cancer, respectively. The 95% confidence interval of the calibration intercepts and slopes contain the values 0 and 1, respectively. Conclusions: The SOURCE prediction models show fair to good c-indices and an overall good calibration. The models are the first in esophageal and gastric cancer to predict survival at diagnosis for a variety of treatments. Future research is needed to demonstrate their value for shared decision-making in clinical practice.
Patients With cT1N0M0 Oral Squamous Cell Carcinoma Benefit From Elective Neck Dissection: A SEER-Based Study
Authors: Wushou Alimujiang , Wang Meng , Yibulayin Feiluore , Feng Lei , Lu Meng-meng , Luo Yuan , Liu Hui , Yang Zhi-cheng
Published: November 2021

Background: The incidence of oral squamous cell carcinoma (OSCC) is increasing, with an estimated 369,000 new patients each year worldwide. Surgery is the primary treatment modality for early-stage OSCC, but there is scant evidence to prove the value of elective neck dissection (END) for relatively small early-stage OSCC. This study aimed to identify factors predicting survival for patients with clinical stage T1N0M0 (cT1N0M0) OSCC and whether up-front END improved survival. Patients and Methods: Patients with cT1N0M0 OSCC who underwent tumor resection with or without END were identified and extracted from the SEER database. Kaplan-Meier survival analysis was used to assess overall survival and disease-specific survival. Prognostic factors were determined using Cox regression analysis. Results: A total of 5,752 patients with cT1N0M0 OSCC were extracted, of whom 2,194 (38.1%) underwent tumor resection surgery with concurrent END and 3,558 (61.9%) underwent only tumor resection. In a multivariate Cox analysis, a relatively advanced age (>62 years) and relatively high pathologic grade were the significant negative predictors, but married status (hazard ratio, 0.709; P=.006) and undergoing END (hazard ratio, 0.708; P<.001) were identified as significant independent positive factors. Conclusions: Patients with cT1N0M0 OSCC gain significant overall and disease-specific survival benefit from END.
Impact of Facility Surgical Volume on Survival in Patients With Cancer
Authors: Stoltzfus Kelsey C. , Shen Biyi , Tchelebi Leila , Trifiletti Daniel M. , Gusani Niraj J. , Walter Vonn , Wang Ming , Zaorsky Nicholas G.
Published: November 2021

Background: Increased facility surgical treatment volume is sometimes associated with improved survival in patients with cancer; however, published studies evaluating volume are heterogeneous and disparate in their patient inclusion and definition of volume. The purpose of this work was to evaluate uniformly the impact of surgical facility volume on survival in patients with cancer. Methods: The National Cancer Database was searched for patients diagnosed in 2004 through 2013 with the 12 cancers most commonly treated surgically. Facilities were stratified by 4 categories using the overall population (low, intermediate, high, and very high), each including 25% of patients, and then stratified by each individual disease site. Five-year postsurgery survival was estimated using both the Kaplan-Meier method and corresponding log-rank tests for group comparisons. Cox proportional hazard models were used to evaluate the effects of facility volume on 5-year postsurgery survival further, adjusted for multiple covariates. Results: A total of 3,923,618 patients who underwent surgery were included from 1,139 facilities. Of these, 40.4% had breast cancer, 12.8% prostate cancer, and 10.0% colon cancer. Most patients were female (65.0%), White (86.4%), and privately insured (51.6%) with stage 0–III disease (64.8%). For all cancers, the risk of death for patients undergoing surgery at very high-volume facilities was 88% of that for those treated at low-volume facilities. Hazard ratios (HRs) were greatest (very high vs low volume) for cancer of the prostate (HR, 0.66; 95% CI, 0.63–0.69), pancreas (HR, 0.75; 95% CI, 0.71–0.78), and esophagus (HR, 0.78; 95% CI, 0.73–0.83), and for melanoma (HR, 0.81; 95% CI, 0.78–0.84); differences were smallest for uterine and non–small cell lung cancers. Overall survival differences were greatest for cancers of the brain, pancreas, and esophagus. Conclusions: Patients treated surgically at higher-volume facilities consistently had improved overall survival compared with those treated at low-volume centers, although the magnitude of difference was cancer-specific.
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
Authors: Tempero Margaret A. , Malafa Mokenge P. , Al-Hawary Mahmoud , Behrman Stephen W. , Benson Al B. , Cardin Dana B. , Chiorean E. Gabriela , Chung Vincent , Czito Brian , Del Chiaro Marco , Dillhoff Mary , Donahue Timothy R. , Dotan Efrat , Ferrone Cristina R. , Fountzilas Christos , Hardacre Jeffrey , Hawkins William G. , Klute Kelsey , Ko Andrew H. , Kunstman John W. , LoConte Noelle , Lowy Andrew M. , Moravek Cassadie , Nakakura Eric K. , Narang Amol K. , Obando Jorge , Polanco Patricio M. , Reddy Sushanth , Reyngold Marsha , Scaife Courtney , Shen Jeanne , Vollmer Charles , Wolff Robert A. , Wolpin Brian M. , Lynn Beth , George Giby V.
Published: November 2021

Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients’ advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.
Can theology be a science? An epistemological reflection
Authors: Andrade Gabriel
Published: November 2021

Many dubious disciplines have been removed from academic institutions, but theology is not one of them, as it is still taught in respectable universities. This article argues that theology does not deserve that special treatment. Theology has long pretended to be a science, but it can never be, because ultimately, theology is grounded on faith and authority, two tenets that run counter to the scientific method. Natural theology appeals to evidence and reason, but it also fails in its endeavor. More recent theologians admit that their discipline is not science per se, but still consider it legitimate in its quest for meaning. There are also reasons to doubt this claim, as there is no need to appeal to the supernatural to find meaning.
Theoretical and methodological basis of music education: structure and contents
Authors: Chen Yanan
Published: November 2021

The research subject of the article is the theoretical and methodological basis of music education represented in a traditional four-level structure (developed by A. Yudin within the system approach), consisting of: 1) a philosophical, 2) a general scientific, 3) a specific scientific, 4) a methodological level. Based on the thesis about the connection between theory and practice in music education, the second part of the article briefly describes the contents of the first three levels of the structure of the theoretical and methodological basis which are believed to be the most academical. The author focuses on two aspects: 1. The goals and potentials of the level under consideration; 2. The problems arising at each level. The author arrives at the following conclusions: 1) the philosophical level of the theoretical and methodological basis of music education, being the most general and therefore the leading one, is necessary for training prospective musicians for the formation of the value, moral and spiritual, and esthetic components of education; 2) the general scientific level helps systematize the philosophic provisions and concepts into certain approaches and principles which can be introduced into the pedagogical practice as models of integral formation of education processes; 3) the level of socio-scientific disciplines, which is the most thoroughly developed due to the close connection with practical aspects and problems, consists in the aspects of the contents of education (musicology), the methodology of teaching (pedagogics), and the study subject/instrument (performance art).   
Implementation of the principle of payment of land-use on the example of land tax: possibilities and issues
Authors: Nadtochii Igor' Olegovich , Plesnyakova Vera Nikolaevna
Published: November 2021

This article examines the relevant problems of land law – one of the most dynamically developing branches of law in the Russian Federation, and one of the first to undergo changes in the context of modernization of vectors of state legal policy. Analysis is conducted on the fundamental importance of the principle of payment of land-use on the example of land tax. The author explores the problems of the object of land tax and tax base, calculation of cadastral value. The conclusion is made that the chosen path of development of the land tax is unfeasible, thereby requiring an alternative solution. According to the legislation of the Russian Federation, land is one of the key economic goods. The Russian legislator gives close attention to the commerce in land of various purpose. Land tax is the equivalent of rental charge. Such similarity is interchangeable in judicial practice. There are a number of issues in land tax regulation. The constituent entities of the Russian Federation are currently limited to establishing the exhaustive list of local taxes. The organizations and private entities are not recognized as taxpayers individuals with regards to land plots in uncompensated limited use or under a lease agreement. The post-Soviet states attribute land plots with ownership right as an object of taxation. The legislative and law enforcement practice on land tax in the Russian Federation indicates a close connection between land and civil legislation. For the purpose of replenishment of budgets, the Russian Federation took the path of increasing the tax burden. It is necessary to find the new ways for implementing the principle of payment of land-use in form of land tax, which would effectively address the problems of local financing.
Authorship characteristics of retracted COVID-19 articles
Authors: Silva Rafaela Carolina da , Heidari Hadiseh , Silva Amanda Mendes da
Published: November 2021

Following the explosion of publications about COVID-19, some of these articles were retracted. These articles are potentially dangerous to public health as they can mislead about the nature of the virus. The growth and sensitive nature of retracted papers led to bibliometrics studies on them, although few, which focused more on the level of documents. This study, instead, examines the characteristics of the authors of these articles. 54 retracted COVID-19 articles that fit our study’s criteria were identified. The results revealed that 32% of these authors were MD, and about one-fifth of them had a past history of publishing retracted articles. The average number of authors per article was 6. Also, according to their profile in the Scopus, the mean number of documents, citations and their H-index were 61, 3159 and 12, respectively. Women also appeared in one-third of the articles as first and last authors. Continued research about retracted COVID-19 articles can continue to help prevent the further dissemination of questionable research findings.
Crónica de una muerte anunciada: el discurso de eta frente a los atentados del 11-M (2004) y la negociación política con el Partido Socialista Obrero Español (2005-2006)
Authors: Ríos Sierra Jerónimo
Published: November 2021

Objective/Context: The definitive dissolution of eta in May 2018 has prompted the appearance of numerous academic publications that mainly focus on the discursive universe of victims of civil society or prominent personalities from the Basque Country. Thus, through an oral history exercise, it seeks to reconstruct eta discourse in an original and unprecedented way in the face of two events that accelerated its disappearance: the attacks of March 11, 2004, and the failed negotiation with the Government of Rodríguez Zapatero between 2005 and 2006. Methodology: The analysis of how these two events were perceived by eta activists is based on nine in-depth interviews conducted with prominent members of the armed group. These were carried out at the end of 2018, a few months after the disappearance of eta, and serve to vindicate the importance of testimonies and oral sources. Originality: So far, very few studies have used this type of source, mainly due to their difficult accessibility. Thus, although the oral history approach has not been unfamiliar to the understanding of eta, the dissolution of the terrorist group has not been studied based solely on the testimony of its members, an aspect that occupies a central place in the following pages, when taking a closer look at how former members perceive and relate the events that marked the end of eta. Conclusions: All the interviewees coincide in pointing out how the 11-M attacks represent a turning point that resulted in the loss of anchors in Basque society. Even though eta was able to arrange a dialogue scenario just a year later, a radical, uncritical position, without a clear roadmap—which is perceptible in the interviewees’ accounts— contributed to discrediting a terrorist group that only five years later announced the end of their armed actions.
Representing the Russian Revolution in Prescribed Russian School History Textbooks
Authors: Zajda Joseph
Published: November 2021

This article offers a new knowledge and insight into understanding the nexus between ideologies, the state, and nation-building—as depicted in transforming images of nation-building and historical understanding of the October 1917 Russian revolution in prescribed history textbooks
in the Russian Federation (RF). Using discourse analysis, and historiography, the article examines critically the role of language and ideology in presenting historical narratives in explaining how do representations of the revolution by different historians, from diverse ideological backgrounds,
compared to the depiction of the October Revolution of 1917, in Russian school textbooks. Classroom teachers and historians, using historiography, interpret the 1917 October revolution in Russia in different ways. These different interpretations reflect the way in which historical understanding
and historical knowledge, influenced by dominant ideologies, are created in history. Current prescribed Russian history textbooks for senior secondary students, which are approved by the Ministry of Education and Science, now regard the Russian Revolution as a significant part of a foundation
narrative, representing a re-invented new meta-narrative of nation-building in the RF.
Human Rights Education and Social Cohesion in South Asia in times of COVID-19
Authors: Ozdowski Seweryn
Published: November 2021

Globalisations, economic, cultural and social change over the last four decades have affected the nature of the discourse in human rights education. The chapter explores human rights education research and the problematic relationship between human rights education and the state, against
the background of globalisation, and economic, political, social and cultural factors. This article aims to link human rights international standards and institutions to grass-roots human rights culture and its impact on social cohesion in South Asia. It begins with an analysis of the nexus
between human rights and social cohesion and draws attention to some ideas that complement both. It then analyses how international human rights standards and associated implementation machinery can be used to advance social cohesion around the world. The article critiques current social cohesion
trends globally - with some references to Australia and South Asia and focuses on the role of National Human Rights Institutions (NHRIs) in advancing human rights culture.
Quadriceps femoris cross-sectional area and specific leg strength: relationship between different muscles and squat variations
Authors: Kojic Filip , Ðurić Saša , Ranisavljev Igor , Stojiljkovic Stanimir , Ilic Vladimir
Published: November 2021

Background

The aim was to determine the relationship between the cross-sectional area of the quadriceps femoris and strength performance in the deep and parallel barbell squat.

Methods

The sample included 16 university students (seven female, 24.1 ± 1.7 years). Muscle strength was expressed as external load, including the one-repetition maximum and the body mass segments involved (calculated according to Dempster’s method). The cross-sectional area of the quadriceps femoris muscles was determined using ultrasound, while leg muscle mass was measured using the Bioelectrical Impedance method.

Results

The cross-sectional areas of the three vastii muscles and leg muscle mass showed moderate to strong correlation with external load in both squat types (r = 0.509–0.873). However, partial correlation (cross-sectional area of quadriceps femoris muscles were controlled) showed significant association only between leg muscle mass and deep squat (r = 0.64, p < 0.05). The cross-sectional area of the vastus lateralis showed a slightly higher correlation with external load in the parallel than in the deep squat (r = 0.67, p < 0.01 vs. r = 0.59, p < 0.05). The regression analysis extracted the vastus medialis cross-sectional area as the most important factor in manifesting strength (parallel squat: R2 = 0.569; deep squat: R2 = 0.499, both p < 0.01). The obtained results suggest that parallel squat strength depends mainly on the cross-sectional area of the vastii muscles, while it seems that the performance in the deep squat requires an additional engagement of the hip and back extensor muscle groups.
Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
Authors: Yan Tao , Wang Kai , Zhao Qidi , Zhuang Junjie , Shen Hongchang , Ma Guoyuan , Cong Lei , Du Jiajun
Published: November 2021

As an innate feature of human beings, gender differences have an influence on various biological phenotypes, yet it does not attract enough attention in genomics studies. The prognosis of multiple carcinomas usually exhibits a favorable ending for female patients, but the neglect of gender differences can cause serious bias in survival analysis. Enhancer RNAs (eRNAs) are mostly downstream of androgens or estrogen. The present study was aimed to screen eRNAs in patients with non-small-cell lung cancer. The findings revealed that eRNA TBX5-AS1 was expressed differently between female and male patients. Meanwhile, its prognostic significance appeared only in male patients with squamous cell carcinoma (SCC) type. The Gene Set Enrichment Analysis proved that the expression level of TBX5-AS1 increased following the activation of the androgen signaling pathway. In pan-cancer analysis, the prognostic prediction based on gender grouping obtained more meaningful results, and the synergy between TBX5-AS1 and its homologous target was more consistent. Furthermore, immunity variations between sexes prompted us to explore the role that TBX5-AS1 played in tumor microenvironment and immunotherapy. The robust evidence proved that male patients with high expression of TBX5-AS1 possessed a malignant immune microenvironment and urgently needed immune checkpoint inhibitor treatment. In conclusion, TBX5-AS1 may be one of the strongest candidates to predict prognosis for male patients with SCC and provide a reference for immunotherapy.
Analysis of Tax Structure Performance and its Ratio in Indonesia
Authors: Amir Amri , Bhakti Adi , Junaidi . , Yacob Syahmardi
Published: November 2021

This study aims to determine and analyze fluctuations in tax revenues, tax structure, and factors that determine tax revenues and ratios in Indonesia. The data used are data on the structure, revenue, and tax ratios from 2001 to 2017. The results show that the tax structure in Indonesia was dominated by direct taxes (income tax and personal tax) with contributions >50% and progressive, while indirect tax contributions (Value-Added Tax, Sales Tax on Luxury Goods, etc.) are around 30%. The tax ratio is still low at 14.58 percent. The results also show that GDP influences tax revenue, while the value of exports and the number of taxpayers have no effect. The tax ratio in Indonesia is influenced by GDP and the value of exports, while the mandatory amount has no effect. From a sample of 150 SMEs in Jambi, it is known that the level of compliance, obedience, assessment of tax servants is considered very good (average value> 80). Taxpayers' confidence in the use of tax funds for the benefit of the state is still low at 40.27, and sanctions for non-negotiable tax violations are also low at 48.53.
Monitoring of Pesticide Residues in Imported Datepalm Fruits in United Arab Emirates
Authors: El-Mageed Nasra M. Abd , Abu-Abdoun Ideisan I. , A. H. Kayaf Kaltham , S. Janaan Abdulla
Published: November 2021

The occurrence of pesticide residues in representative samples collected from imported dates palm fruits during 2020 to United Arab Emirates (UAE) was investigated to ensure compliance with the standard specifications and requirements by the regulatory and supervisory authorities, maintain the health and safety of consumers and improve food safety. An accurate, rapid, and reliable method for the simultaneous determination of pesticide multi-residues in 230 samples imported dates by liquid chromatography coupled with tandem mass spectrometry (LC–ESI (+)-MS/MS) operating in multiple reaction monitoring (MRM) mode and modified quick, easy, cheap, effective, rugged, safe (QuEChERS) method was used. The performance of the analytical method was validated in accordance with EU SANCO guidelines (SANTE/12682/2019) for monitoring pesticide multi-residues to check compliance with existing regulations, especially for European Community. Residues level of 343 compounds were determined in 230 samples. Results indicated that the percentage of samples with residues above the maximum residue levels (MRL) was 4.34% in dates samples, whereas samples with residues within MRL were 7.39% in dates samples. A total of 230 samples of 88.26% were free from detectable residues. Out of the 343 pesticides tested, 11 pesticides were found above the limit of detection, according to UAE, Codex, and European regulations. The main purpose of this work is to inform citizens and traders who have concerns about food safety on the capability of the MOCCAE on quality assurance regarding pesticide residue in imported food.
Evaluation of Pathogenic Potentials of Microbial Contaminants from Naira Notes in Nigeria
Authors: Enweani Ifeoma Bessie , Anyanwu Chinyere Nkemjika , Obeagu Emmanuel Ifeanyi
Published: November 2021

The study was done to determine burden of fiat currencies. A total of Six hundred and twenty four pieces of different denominations of naira notes obtained from banks in Enugu metropolis and samples of nose swabs aseptically collected from fifty two note counters from those banks were examined for similar bacterial and fungal contaminants. All sequences were identified using the Basic Local Alignment Search Tool (BLAST) on National Center for Biotechnology Information (NCBI) website. While the fungi amplicons yielded DNA bands of approximately 650 base pair, that of the bacterial isolates were approximately 850 base pair. Proteus mirabilis (NR11449.1) and Escherichia coli (LN831043.1) were identical and selected from the bacterial category while Aspergillus fumigatus (MK910068), Aspergillus flavus (JQ860302) and Aspergillus niger (MK461093) were identical and selected from the fungal category. Rats inoculated orally with Escherichia coli and Proteus mirabilis presented with watery stool and reduction of weight by 16+0.4g after two weeks of commencement of inoculation. They showed reduction in activity and reduced locomotion when compared with the control. There were no physically observable changes in the other test groups. In the hematological investigation, the mean PCV in % were 39±1.0 for the E. coli, 40±0.4 for P. mirabilis, 35±0.2 for A. niger, 40±0.7 for A. fumigatus and 37±0.1 for A .flavus. These varied significantly at p<0.05 with the control which has mean PCV of 45±0.3. The differential leucocyte count showed a marked increase in the % neutrophil (E. coli 73±0.1, P. mirabilis 70±0.1, A. niger 78±1.1, A. fumigatus 59±0.3 and A. flavus 62±1.0) when compared with the control rats with percentage neutrophil of 20±0.2. There was also an increase in the white blood cell count of the test groups when compared with the control. Histopathological study of the lungs of the rats inoculated nasally with Aspergillus niger showed necrosis of the alveolar epithelium. This study has shown that naira notes could be a reservoir of microorganisms of medical importance which in turn could become vectors for the transmission of diseases in the society.