bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Isolated Hypothyroxinemia and Subclinical Hypothyroidism With Birthweight: A Cohort Study in Japan
Authors: Sankoda Akiko , Arata Naoko , Sato Shiori , Umehara Nagayoshi , Morisaki Naho , Ito Yushi , Sago Haruhiko , Yano Yuichiro , Horikawa Reiko
Published: April 2023

Context

Isolated hypothyroxinemia (low maternal free thyroxine [FT4] in the absence of thyroid-stimulating hormone [TSH] elevation) and subclinical hypothyroidism (high TSH in the absence of FT4 elevation) during early pregnancy are common. However, there are limited data regarding pregnancy outcomes, particularly their association with birthweight.

Objective

We assessed the association between isolated hypothyroxinemia and subclinical hypothyroidism during the first trimester and birthweight.

Methods

Analyses were conducted using a database of pregnant women (n = 1105; median age, 35 years) who delivered at the National Center for Child Health and Development, a tertiary hospital in Tokyo. The primary outcomes included the rates of small for gestational age (SGA), large for gestational age (LGA), and low birth weight.

Results

Of the 1105 pregnant women, 981 were classified into the euthyroidism group, 25 into the isolated hypothyroxinemia group, and 26 into the subclinical hypothyroidism group during the first trimester. The prevalence of SGA was significantly higher in isolated hypothyroxinemia and subclinical hypothyroidism groups than the euthyroidism group (28.0% and 19.2%, respectively, vs 5.7%; P < .01). The odds ratio with 95% CI for SGA was 12.51 (4.41-35.53) for isolated hypothyroxinemia and 4.44 (1.57-12.56) for subclinical hypothyroidism in a multivariable adjustment model. Isolated hypothyroxinemia and subclinical hypothyroidism were not significantly associated with LGA and low birth weight.

Conclusion

Pregnant women with isolated hypothyroxinemia and subclinical hypothyroidism in the first trimester have an increased likelihood of SGA. Screening and careful perinatal checkups for isolated hypothyroxinemia and subclinical hypothyroidism may help identify pregnant women at high risk for SGA.
Diagnosis and Treatment of Cerebral Venous Thrombosis
Authors: Liberman Ava L.
Published: April 2023

OBJECTIVE

Cerebral venous thrombosis (CVT), thrombosis of the dural sinus, cerebral veins, or both, is a rare cerebrovascular disease. Although mortality rates after CVT have declined over time, this condition can result in devastating neurologic outcomes. This article reviews the latest literature regarding CVT epidemiology, details new factors associated with the development of CVT, and describes advances in CVT treatment. It also contains a discussion of future directions in the field, including novel diagnostic imaging modalities, and potential strategies to reduce the risks associated with CVT.

LATEST DEVELOPMENTS

The incidence of CVT may be as high as 2 per 100,000 adults per year. It remains a difficult condition to diagnose given its variable clinical manifestations and the necessity of neuroimaging for confirmation. The COVID-19 pandemic has revealed a novel CVT trigger, vaccine-induced immune thrombotic thrombocytopenia (VITT), as well as an association between COVID-19 infection and CVT. Although VITT is a very rare event, timely diagnosis and treatment of CVT due to VITT likely improves patient outcomes. Direct oral anticoagulants are currently being used to treat CVT and emerging data suggest that these agents are as safe and effective as vitamin K antagonists. The role of endovascular therapy to treat CVT, despite a recent clinical trial, remains unproven.

ESSENTIAL POINTS

The incidence of CVT has increased, outcomes have improved, and the use of direct oral anticoagulants to treat CVT represents an important advance in the clinical care of these patients. Rates of CVT as a complication of COVID-19 vaccines using adenoviral vectors are very low (<5 per million vaccine doses administered), with the benefits of COVID-19 vaccination far outweighing the risks.
Diagnosis and Management of Cardioembolic Stroke
Authors: Yaghi Shadi
Published: April 2023

OBJECTIVE

Cardioembolic stroke accounts for nearly 30% of ischemic strokes. Prompt diagnosis of the underlying mechanism may improve secondary prevention strategies. This article reviews recent randomized trials, observational studies, case reports, and guidelines on the diagnosis and treatment of cardioembolic stroke.

LATEST DEVELOPMENTS

Several pathologies can lead to cardioembolic stroke, including atrial fibrillation, aortic arch atheroma, patent foramen ovale, left ventricular dysfunction, and many others. Secondary stroke prevention strategies differ across these heterogeneous mechanisms. In addition to medical treatment advances such as the use of direct oral anticoagulants in patients with atrial fibrillation, surgical treatments such as closure of patent foramen ovale have been shown to reduce the risk of recurrent stroke in select patients. Furthermore, left atrial appendage occlusion is a promising strategy for patients with atrial fibrillation who are candidates for short-term oral anticoagulation therapy but not long-term oral anticoagulation therapy.

ESSENTIAL POINTS

A thorough diagnostic evaluation is essential to determine cardioembolic causes of stroke. In addition to risk factor management and lifestyle modifications, identification and targeting of the underlying cardioembolic stroke mechanisms will lead to improved stroke prevention strategies in patients with cardioembolic stroke.
Endoscopic Endonasal Transcavernous Posterior Clinoidectomy With Inferior Hypophyseal Artery Preservation for a Cavernous Sinus Hemangioma: Technical Case Report
Authors: Gosal Jaskaran S. , Bhuskute Govind S. , Alsavaf Mohammad Bilal , Wu Kyle C. , Salem Eman H. , Jawad Basit , Kelly Kathleen M. , Carrau Ricardo L. , Prevedello Daniel M.
Published: April 2023

BACKGROUND AND IMPORTANCE

Unilateral inferior hypophyseal artery (IHA) sacrifice is routinely performed during endoscopic endonasal transcavernous interdural posterior clinoidectomy. However, unilateral IHA sacrifice presents the risk of temporary postoperative diabetes insipidus. We present a case demonstrating the feasibility of endoscopic endonasal transcavernous posterior clinoidectomy without IHA sacrifice.

CLINICAL PRESENTATION:

A 62-year-old man presented with progressive weakness of his left oculomotor and abducens nerves. MRI of the brain revealed a small lesion suspicious for hemangioma in the posterior compartment of the left cavernous sinus. Following an endoscopic endonasal transcavernous approach using the interdural peeling technique, an IHA-sparing posterior clinoidectomy was performed to provide access to the tumor in the posterior cavernous sinus. After complete resection, the patient's symptoms improved and a diagnosis of cavernous sinus hemangioma was confirmed by histopathology.

CONCLUSION

Unilateral IHA preservation may be performed safely when performing a transcavernous interdural posterior clinoidectomy. IHA preservation can be readily achieved if the artery is redundant, the lesion is small and located in the posterior cavernous sinus, and there is a short posterior clinoid, ultimately avoiding the risk of transient postoperative diabetes insipidus.
Customized External Cranioplasty for Management of Syndrome of Trephined in Nonsurgical Candidates
Authors: Ghinda Cristina D. , Stewart Ryan , Totis Francesca , Siewerdsen Jeffrey H. , Anderson William S.
Published: April 2023

BACKGROUND:

Craniectomies represent a lifesaving neurosurgical procedure for many severe neurological conditions, such as traumatic brain injury. Syndrome of trephined (SoT) is an important complication of decompressive craniectomy, and cranial reconstruction is the definitive treatment. However, many patients cannot undergo surgical intervention because of neurological status, healing of the primary surgical wound, or the presence of concurrent infection, which may prevent cranioplasty.

OBJECTIVE:

To offer a customized external cranioplasty option for managing skull deformities for patients who could not undergo surgical intervention for definitive cranioplasty.

METHODS:

We describe the design and clinical application of an external cranioplasty for a patient with a medical history of intractable epilepsy, for which she underwent multiple right cerebral resections with a large resultant skull defect and SoT.

RESULTS:

The patient had resolution of symptoms and restoration of a symmetrical skull contour with no complication at 17 months.

CONCLUSION:

Customized external cranioplasty can improve symptoms associated with SoT for patients who cannot undergo a definitive cranioplasty. In addition, inset monitoring options, such as electroencephalography or telemetric intracranial pressure sensors, could be incorporated in the future for comprehensive monitoring of the patient's neurological condition.
Percutaneous Rhizotomy of the Gasserian Ganglion in Patients With Mass Lesion–Associated Trigeminal Neuralgia: A Case Series
Authors: Petitt Jordan C. , Murayi Roger , Potter Tamia , Ahorukomeye Peter , Jarmula Jakub , Recinos Pablo F. , Barnett Gene H. , Kshettry Varun R.
Published: April 2023

BACKGROUND:

Patients with trigeminal neuralgia (TN) secondary to mass lesions are typically treated by directly addressing the underlying pathology. In cases of TN not alleviated by treatment of the pathology, percutaneous balloon compression (PBC) and glycerol rhizotomy (Gly) are simple and effective ways to alleviate pain. However, there is limited literature on the use of these techniques for patients with TN caused by mass lesions.

OBJECTIVE:

To describe the use of PBC/Gly to treat mass lesion–related TN.

METHODS:

We report a retrospective, single-institution, descriptive case series of patients who presented with TN secondary to tumor or mass-like inflammatory lesion from 1999 to 2021. Patients with primary, idiopathic, or multiple sclerosis–related TN were excluded. Outcomes included Barrow Neurological Institute (BNI) pain intensity and hypesthesia scores, pain persistence, and postoperative complications.

RESULTS:

A total of 459 procedures were identified, of which 16 patients met the inclusion criterion (14 PBC and 2 Gly). Of the 15 patients with tumors, 12 had TN pain despite prior tumor-targeted radiation. Short-term (<3 months) BNI pain intensity improvement occurred in 15 (93.8%) patients. The mean follow-up was 54.4 months. Thirteen (81.3%) patients were pain-free (Barrow Neurological Institute pain intensity scale: IIIa–50%; I–25.0%; II–6.3%) for a mean of 23.8 (range 1-137) months. Ten patients (62.5%) had pain relief for ≥6 months from first procedure. New facial numbness developed immediately postprocedure in 8 (50%) patients. Transient, partial abducens nerve palsy occurred in 1 patient.

CONCLUSION:

PBC/Gly is an effective option for medically refractory TN in patients with mass-associated TN and is a viable option for repeat treatment.
Minimally Invasive Dorsal Approach for the Treatment of Giant Presacral Schwannomas
Authors: Feigl Guenther C , Britz Gavin , Staribacher Daniel , Kuzmin Dzmitry
Published: April 2023

BACKGROUND:

The treatment of giant presacral schwannomas is currently a grand challenge for neurosurgeons. Although these tumors are benign and do not infiltrate the surrounding tissues, it is difficult to choose the best surgical approach because they are surrounded by the pelvic organs and great vessels. There is no universally accepted approach to the surgical treatment because giant presacral schwannomas are rare in the population. The anterior approach through laparotomy is more often recommended in the literature. A dorsal approach that involves laminotomy and stabilization is also described in the literature. However, these approaches are rather traumatic for the patient and have both intraoperative and postoperative risks.

OBJECTIVE:

To report a minimally invasive dorsal approach for the treatment of giant presacral schwannomas.

METHODS:

We present a fundamentally new approach to the treatment of these tumors using a minimally invasive dorsal approach, based on the specific anatomy and growth of giant presacral schwannomas. This approach is using the potential of modern neurosurgery.

RESULTS:

We describe 2 cases of successful total tumor resection using this novel surgical approach. No complications have been registered after the surgery.

CONCLUSION:

A minimally invasive dorsal approach for the treatment of giant presacral schwannomas is sufficient for complete tumor removal, minimizes intraoperative and postoperative risks, is associated with good cosmetic effect, and can be successfully applied in surgical practice.
Dissecting pleiotropic functions of the wheat Green Revolution gene Rht-B1b in plant morphogenesis and yield formation
Authors: Xu Dengan , Bian Yingjie , Luo Xumei , Jia Chenfei , Hao Qianlin , Tian Xiuling , Cao Qiang , Chen Wei , Ma Wujun , Ni Zhongfu , Fu Xiangdong , He Zhonghu , Xia Xianchun , Cao Shuanghe
Published: April 2023

The utilization of reduced plant height genes Rht-B1b and Rht-D1b, encoding homeologous DELLA proteins, led to the wheat Green Revolution (GR). However, the specific functions of GR genes in yield determination and the underlying regulatory mechanisms remained unknown. Here, we validated that Rht-B1b, as a representative of GR genes, affects plant architecture and yield component traits. Upregulation of Rht-B1b reduced plant height, leaf size and grain weight, but increased tiller number, tiller angle, spike number per unit area, and grain number per spike. Dynamic investigations showed that Rht-B1b increased spike number by improving tillering initiation rather than outgrowth, and enhanced grain number by promoting floret fertility. Rht-B1b reduced plant height by reducing cell size in the internodes, and reduced grain size or weight by decreasing cell number in the pericarp. Transcriptome analyses uncovered that Rht-B1b regulates many homologs of previously reported key genes for given traits and several putative integrators for different traits. These findings specify the pleiotropic functions of Rht-B1b in improving yield and provide new insights into the regulatory mechanisms underlying plant morphogenesis and yield formation.
Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus
Authors: Abazari Danya , Wild Angela R. , Qiu Tian , Dickinson Bryan C. , Bamji Shernaz X.
Published: April 2023

Activity-induced changes in protein palmitoylation can regulate the plasticity of synaptic connections, critically impacting learning and memory. Palmitoylation is a reversible post-translational modification regulated by both palmitoyl-acyl transferases that mediate palmitoylation and palmitoyl thioesterases that depalmitoylate proteins. However, it is not clear how fluctuations in synaptic activity can mediate the dynamic palmitoylation of neuronal proteins. Using primary hippocampal cultures, we demonstrate that synaptic activity does not impact the transcription of palmitoylating and depalmitoylating enzymes, changes in thioesterase activity, or post-translational modification of the depalmitoylating enzymes of the ABHD17 family and APT2 (also known as LYPLA2). In contrast, synaptic activity does mediate post-translational modification of the palmitoylating enzymes ZDHHC2, ZDHHC5 and ZDHHC9 (but not ZDHHC8) to influence protein–protein interactions, enzyme stability and enzyme function. Post-translational modifications of the ZDHHC enzymes were also observed in the hippocampus following fear conditioning. Taken together, our findings demonstrate that signaling events activated by synaptic activity largely impact activity of the ZDHHC family of palmitoyl-acyl transferases with less influence on the activity of palmitoyl thioesterases.
Developmental environment has lasting effects on amphibian post-metamorphic behavior and thermal physiology
Authors: Ohmer Michel E. B. , Hammond Talisin T. , Switzer Samantha , Wantman Trina , Bednark Jeffery G. , Paciotta Emilie , Coscia Jordan , Richards-Zawacki Corinne L.
Published: April 2023

Environmental challenges early in development can result in complex phenotypic trade-offs and long-term effects on individual physiology, performance and behavior, with implications for disease and predation risk. We examined the effects of simulated pond drying and elevated water temperatures on development, growth, thermal physiology and behavior in a North American amphibian, Rana sphenocephala. Tadpoles were raised in outdoor mesocosms under warming and drying regimes based on projected climatic conditions in 2070. We predicted that amphibians experiencing the rapid pond drying and elevated pond temperatures associated with climate change would accelerate development, be smaller at metamorphosis and demonstrate long-term differences in physiology and exploratory behavior post-metamorphosis. Although both drying and warming accelerated development and reduced survival to metamorphosis, only drying resulted in smaller animals at metamorphosis. Around 1 month post-metamorphosis, animals from the control treatment jumped relatively farther at high temperatures in jumping trials. In addition, across all treatments, frogs with shorter larval periods had lower critical thermal minima and maxima. We also found that developing under warming and drying resulted in a less exploratory behavioral phenotype, and that drying resulted in higher selected temperatures in a thermal gradient. Furthermore, behavior predicted thermal preference, with less exploratory animals selecting higher temperatures. Our results underscore the multi-faceted effects of early developmental environments on behavioral and physiological phenotypes later in life. Thermal preference can influence disease risk through behavioral thermoregulation, and exploratory behavior may increase risk of predation or pathogen encounter. Thus, climatic stressors during development may mediate amphibian exposure and susceptibility to predators and pathogens into later life stages.
Bestattung in der Wallanlage
Authors: Trancík Viera
Published: April 2023

Viera Trancík, unter Mitarbeit von Thomas Boni, Alfred Geissmann
Während des Baues des Basler Murus Gallicus wurde eine Bestattung niedergelegt. Auch wenn diese Art der Bestattung etwas ungewöhnlich erscheint, ist sie doch nicht völlig unbekannt und scheint ab und an im spätkeltischen Kulturbereich praktiziert worden zu sein. Eine Deutung dieser Praxis kann derzeit jedoch nicht gegeben werden; möglich wäre es, an eine Art Bauopfer zu denken.
kaiserzeitlichen Funde
Authors: Matteotti René
Published: April 2023

Die Auswertung der römischen Funde wurde in zwei Teile gegliedert. Der erste befasst sich mit den Funden aus den Horizonten der römischen Kaiserzeit. Anhand statistischer und formaltypologischer Untersuchungen sollen dabei vor allem Aussagen zur Schichtgenese und Zeitstellung der einzelnen Horizonte gewonnen werden. Im zweiten Teil der Fundauswertung erfolgt die Analyse spätrömischer Funde, die - sekundär verlagert - in grosser Anzahl in mittelalterlichen Horizonten zum Vorschein gekommen sind. Es stehen dabei weniger chronologische als vielmehr wirtschaftshistorische Fragestellungen im Vordergrund.
früh- und hochmittelalterliche Friedhof, die Skelette
Authors: Mundschin Marcel , Böni Thomas
Published: April 2023

Ungefähr vom 7. bis ins 10. Jh. n. Chr. besteht auf dem östlichen Teil des Grabungsareals ein Friedhof. In den Grabungen 1991 und 1992 wurden 32 Einzelbestattungen und 4 Doppelgräber festgestellt, zusätzlich kam ein separat bestatteter amputierter Fuss zum Vorschein.
mittelalterlichen Funde
Authors: Matteotti René
Published: April 2023

Die Anzahl der mittelalterlichen Funde in den während des Mittelalters entstandenen Horizonten ist äusserst gering. Sie variiert zwischen 0 und 15 Fragmenten, und entspricht bei den Horizonten mit einer Fundzahl von n > 100 einem Anteil von Null bzw. 2 n%. Drei Horizonte resp. Strukturen (Horizont M 1.2 und M 2a.2 sowie Eingriff 4, 1992, der von Horizont M 1.1 aus eingetieft wurde), die aufgrund der Schichtenabfolge mittelalterlicher Zeitstellung sind, entbehren gar mittelalterlicher Keramik und enthalten ausschliesslich umgelagertes römisches oder spâtlatènezeitliches Altmaterial! Diese Gründe veranlassten uns, auf eine detaillierte  statistische Auswertung der mittelalterlichen Funde zu verzichten.
Münzfunde vom Friedhof der ersten Basler Judengemeinde
Authors: Schärli Beatrice , Matzke Michael
Published: April 2023

Seit ihrer Entdeckung im Jahre 1937 werden zwei Münzkomplexe aus dem mittelalterlichen Judenfriedhof Basels immer wieder erwähnt und zitiert. Es handelt sich um zwei gänzlich unterschiedliche Gruppen von Münzen, zum einen um 145 Pfennige der Münzstätten Basel, Zofingen, Laufenburg, Zürich und (Schwäbisch) Hall, und zum anderen um 55 französische und einen holländischen Turnosgroschen.

Beide Fundkomplexe, der Turnosen- wie der Pfennigfund, zeigen ein auffallend homogenes Bild: Die französischen Turnosen wurden in den Jahren um 1266 bis 1305, mehrheitlich unter Philipp IV. (1285-1314), geprägt. Die Pfennige aus Zofingen, Basel, Hall, Laufenburg und Zürich stammen, abgesehen von drei Hellern der ersten Jahrhunderthälfte, alle aus dem letzten Viertel des 13. Jahrhunderts und reichen wahrscheinlich bis in die ersten Jahre des 14. Jahrhunderts.
anthropologische Auswertung der Skelettreste aus der Grabung bei der Dorfkirche 1978
Authors: Mundschin Marcel
Published: April 2023

Beim vorliegenden Skelettmaterial aus der Grabungskampagne von 1978 handelt es sich um insgesamt 57 Individuen. Sie stammen grösstenteils aus dem Bereich zwischen der Umfassungs- und der Speichermauer der Riehener Dorfkirche.

Durch die Unterteilung des Materials in vier nicht zeitgleiche Gruppen und die dadurch noch geringeren Individuenzahlen derselben fehlte die für die statistische Auswertungen notwendige Basis.
bronzezeitlichen Funde aus dem Kanton Basel-Stadt
Authors: Holstein Dieter
Published: April 2023

In dieser Arbeit wurden sämtliche bronzezeitlichen Fundstellen auf dem Gebiet des heutigen Kantons Basel-Stadt zusammengestellt. Es handelt sich um Siedlungsfunde in Gross- sowie in Kleinbasel und Kleinhüningen, belegt vor allem durch grobkeramische Gefässe. Die wenigen Grabfunde (Bronzeschwerter, Lanzenspitzen, Armringe) stammen mehrheitlich vom Gemeindebann Riehen. Ein Depotfund, bestehend aus Sicheln, Lappenbeilen, Lanzenspitzen sowie Beinringen, kam auf der Elisabethenschanze zum Vorschein. Einzelfunde fanden sich u.a. im Rheinbett und im Rheinhafen. Die Funde stammen schwerpunktmässig aus der späten Mittelbronzezeit und der Spätbronzezeit.
Oxygen as obturation biomaterial in endodontic treatment: development of novel membranous dental restoration system
Authors: Wahyudi Didi , Kusumasari Citra
Published: April 2023

Complexities in obturation and difficulties in disinfection are the major problems that make endodontic treatment very time-consuming. A new perspective is needed to reduce the working time as well as to answer these two problems. Until now, none of the established obturation techniques for root canal filling can guarantee a perfect seal. Solid substances cannot be manipulated easily to fill the tiny branches of the root canal system hermetically. At the same time, anaerobes and facultative anaerobes, especially Enterococcus faecalis, are very dominant in endodontic infections discussion. As shown in many studies, it is extremely difficult to perfectly disinfect Enterococcus faecalis even by using some irrigating solutions with strong antibacterial properties. Under anaerobic conditions, the invasion efficiency of facultative anaerobes is increased. In case irrigation and disinfection cannot totally eliminate anaerobes and facultative anaerobes, a new strategy is also needed to deal with the bacteria that still survive in the root canal. Oxygen can fill the root canal system with ease, eliminate anaerobes, and prevent facultative anaerobes from being pathogenic. Therefore, using oxygen as obturation biomaterial after proper cleaning and shaping procedures is expected to solve the two major endodontic problems. The aim of this article was to discuss a new possible concept of dental restoration system that uses an oxygen-permeable membrane to decrease the time required in endodontic treatment. The membrane is placed at the orifice of a duct created to connect the entire root canal system with free air outside the restoration. The function of the membrane is more or less similar to the mask used during the COVID-19 pandemic, as it enables the oxygen to circulate while preventing any fluid, debris, and microorganisms from passing. We hypothesize that the oxygen circulating in the root canal system will also act as an antimicrobial agent that is constantly renewed.
Understanding the genetic basis of the incompatibility of IncK1 and IncK2 plasmids
Authors: Rozwandowicz Marta , Kant Arie , Wagenaar Jaap , Mevius Dik , Hordijk Joost , Brouwer Michael
Published: April 2023

Antimicrobial resistance is a persistent challenge in human and veterinary medicine, which is often encoded on plasmids which are transmissible between bacterial cells. Incompatibility is the inability of two plasmids to be stably maintained in one cell which is caused by the presence of identical or closely related shared determinants between two plasmids originating from partition or replication mechanisms. For I-complex plasmids in Enterobacteriacae, replication- based incompatibility is caused by the small antisense RNA stem-loop structure called RNAI. The I-complex plasmid group IncK consists of two compatible subgroups, IncK1 and IncK2, for which the RNAI differs only by five nucleotides. In this study we focussed on the interaction of the IncK1 and IncK2 RNAI structures by constructing minireplicons containing the replication region of IncK1 or IncK2 plasmids coupled with a kanamycin resistance marker. Using minireplicons excludes involvement of incompatibility mechanisms other than RNAI. Additionally, we performed single nucleotide mutagenesis targeting the five nucleotides that differ between the IncK1 and IncK2 RNAI sequences of these minireplicons. The obtained results show that a single nucleotide change in the RNAI structure is responsible for the compatible phenotype of IncK1 with IncK2 plasmids. Only nucleotides in the RNAI top loop and interior loop have an effect on minireplicon incompatibility with wild type plasmids, while mutations in the stem of the RNAI structure had no significant effect on incompatibility. Understanding the molecular basis of incompatibility is relevant for future in silico predictions of plasmid incompatibility.
Painting and Drawing in the Planning of Project Tasks �
Authors: Ul'yanova N.
Published: April 2023

The article is devoted to the importance and use of painting and drawing possibilities in planning project tasks. The main factor of the research is the search for new design solutions in the field of fine arts. The purpose of the research is in professional orientation to drawing and painting. Based on the goal, the whole focus of the work is to develop and deepen the concept of aesthetics of spaces, through the organization of a phased design system. Methods are associated with the understanding and development of students' knowledge and skills in organizing a comfortable environment, in combination with technologies of project mastery. The methods under consideration are based on the practical implementation of architectural and design projects and on practical work. The research is aimed at finding solutions in the field of color and coloristic presentation of modern residential and public buildings, in order to improve the situation in the aesthetic component of architecture. Research objectives in the creation of an integrated design system, in the search for and analysis of artistic possibilities to create a comfortable environment.
Personal factors of professional success of employees of internal affairs bodies
Authors: Goncharova Natal'ya
Published: April 2023

Professional success is determined by a combination of factors of objective and subjective content that ensure the achievement of a significant result in activities, job satisfaction and the development of the personal potential of the organization's employees. Objective performance results and positive subjective experiences of professional success are a powerful motivator of professional activity and help to increase its effectiveness. The purpose of the study is determined by the need to establish the features of the factor structure of personality traits that act as resources for professional success. Subject of study: factorial structure of personality traits. Research methods: personality traits were considered in accordance with the classes of factors proposed in the psychodiagnostic methodology "California Personality Questionnaire - CPI". The sample of the study was represented by male employees of the internal affairs bodies (n=97), divided into two groups of "successful" (n=65) and "unsuccessful" (n=32) based on an expert assessment. The results of the study made it possible to establish important characteristics of personal factors of professional success, which constitute a significant psychological resource for the professional development of subjects of professional activity.It has been established that the main factors are subjective, reflecting the effectiveness of effective interpersonal interaction, the normativity and maturity of the individual, the focus on achieving and developing intellectual potential, a constructively optimistic lifestyle, which determines psychological well-being and job satisfaction. The scope of the research results is determined by the specifics of the organization of psychological support for the activities of employees of internal affairs bodies, the tasks of moral and psychological training, the goals of personality development and the formation of skills of official behavior. Prospects for further research lie in the plane of analyzing the parameters of the identified factors, identifying patterns in the formation of professional success and its subjective components.
Multiparametric psychological diagnostics of propensity to gaslighting in interpersonal relationships
Authors: Petrov Vladislav
Published: April 2023

The article focuses on the study of the main psychometric characteristics of the author's questionnaire for assessing the propensity to gaslighting in interpersonal relationships. A multiparametric approach to the psychodiagnostics of the phenomenology of gaslighting is defined as the subject of scientific research, the goals are to develop a diagnostically significant model for assessing the propensity to gaslighting in interpersonal relationships, implementing it in the questionnaire of the same name with its subsequent approbation. The research methodology was based on axiological, humanistic, activity and polysubject approaches in psychology, relationship theory and deviantology. Semantic content analysis, expert survey, psychological testing, self-assessment were used at different stages of scientific research. The total volume of the empirical sample was 165 people (including 17 experts and 148 subjects). Mathematical and statistical data processing involved the calculation of descriptive statistics and correlation analysis, which was implemented in MS Excel and IBM SPSS Statistics v 27 software products.

Based on the results of theoretical and analytical research, a six-parametric gaslighting model was developed, which was the basis for the corresponding questionnaire. The measuring framework of the methodology and the degree of severity of gaslighting is formed by six private scales: 1) «behavioral intolerance»; 2) «expressive dominance»; 3) «projection of personal problems»; 4) «intrigue» (manipulation); 5) «verbal-behavioral discongruence»; 6) «devaluation of the other», from which an integral indicator is formed. During the psychometric study of the questionnaire, its high criterion validity was confirmed – statistically significant correlations with self-assessments of the same name were established (Rs = 0.42-0.63 at p=0.01). It is assumed that the technique has a good diagnostic potential, and can be used to study the phenomenology of gaslighting. Innovative are: the stimulus material of the questionnaire, the description of diagnostic scales, psychometric parameters of the methodology. The material makes it possible to provide psychodiagnostics with innovative diagnostic tools that provide solutions to a wide range of tasks in the field of not only psychodiagnostics, but prevention, assistance and correction
Analysis of foreign approaches to the study of legal consciousness
Authors: Maltseva Tatyana , Skvortsova Daria
Published: April 2023

The duration of the process of formation of legal values and legal behavior of an individual emphasizes the importance of taking into account attitudes mediated by national traditions, religious ideas, value-semantic orientations in the study of the level of legal consciousness. In our opinion, also for a comprehensive study of the individual legal consciousness of the individual, and in general, in the analytical assessment of the study of the category of legal consciousness, it is worth considering not only the dynamics of professional self-determination, but also belonging to the profession, including adherence to all those moral and ethical beliefs and principles associated with her. Such a multidimensional, complementary approach will allow taking into account the professional features of legal awareness, can contribute to a more complete picture of the understanding of the mechanisms of reflection of legal reality, applicable both to the sphere of one professional community and society. The advantage of the article is the disclosure of the main key points of development of the study of legal consciousness of foreign researchers.
Modern trends of professional training of specialists in the conditions of digital transformation of science and education
Authors: Zybin Dmitry , Antonovskiy Aleksandr , Churakov Denis
Published: April 2023

The article examines the current trends of professional training of specialists in the conditions of digital transformation of science and education. Integration of information technologies into almost all spheres of life support of citizens, digitalization of various types of professional activities conceptually changes not only the previously existing formats of relations, but also directly affects the culture and forms of professional and interpersonal interaction between people, and also provides a certain level of information socialization. Taking into account the uniqueness of the possibilities of information technologies in science and education allows us to talk about a qualitative change in the socio-economic life of society, rethinking scientific and educational activities, effective communication between subjects of digital transformation at various levels. Priority and significant today are such trends in the context of professional training of specialists as: continuing education of specialists studying, taking into account the use of various information resources; collective form of interaction in teaching, with a focus on solving certain applied tasks, focusing on obtaining specific practical knowledge, skills and abilities; implementation of a differentiated approach to building pedagogical interaction between the teacher and students, individualization of learning; use of distance and mixed learning formats; improvement of educational platforms in educational practice; the use of artificial intelligence technologies in online education, virtual and augmented reality, gamification of the educational process; the construction and use of digital twins in education; the acquisition of knowledge, skills, skills, competencies in the framework of mentoring, with the participation of a professional (teacher-mentor, teacher-practitioner, practicing consultant, expert); the development of educational programs, corresponding to the priority directions of development of society and economy. The use of new educational practices in the framework of professional training, based both on the use of information technologies and on traditional approaches of pedagogical interaction, allows not only to realize learning goals, but also to be involved in active social life and professional activities.
On Aligning Non-Order-Associated Binary Decision Diagrams
Authors: Bochkarev Alexey A. , Smith J. Cole
Published: April 2023

Recent studies employ collections of binary decision diagrams (BDDs) to solve combinatorial optimization problems. This paper focuses on the problem of optimally aligning two BDDs, that is, transforming them to enforce a common order of variables while keeping the total size of the diagrams as small as possible. We address this problem, which is known to be NP-hard, by introducing and studying a simplified problem instead of working with the more complex original diagrams. We discuss some basic properties of the simplified problem, design a corresponding heuristic for the original problem, and show empirically that this approach yields good quality alignments while significantly reducing the complexity of intermediate diagram transformations. We highlight the practicality of this approach in the context of a variation of the uncapacitated facility location problem.

History: Accepted by Andrea Lodi, Area Editor for Design and Analysis of Algorithms–Discrete.

Funding: This work was supported by the Office of Naval Research [Grant N00014-17-1-2421].

Supplemental Material: The online appendices are available at https://doi.org/10.1287/ijoc.2023.1293 .
When Liability Is Not Enough: Regulating Bonus Payments in Markets with Advice
Authors: Honda Jun , Inderst Roman , Ottaviani Marco
Published: April 2023

We introduce a model of advice in which firms steer advisors through nonlinear incentive schemes. In addition to developing an isomorphism to pricing with mixed bundling, we obtain three main insights. First, firms optimally use nonlinear bonuses to economize on the rent paid to advisors. Second, equilibrium bonus payments induce advisors to make biased recommendations that are artificially contingent on each other, resulting in an inefficient allocation. Third, if advisor liability is stepped up, firms respond by increasing the size of the bonus, leaving advisor bias unchanged. These results shed light on prevailing compensation practices for advisors and support direct regulatory interference.

This paper was accepted by Joshua Gans, business strategy.
O medo nas narrativas de experiência de Liudmila Petruchévskaia
Authors: Gonçalves Gomes Emannuel
Published: April 2023

Este artigo busca analisar alguns contos selecionados do livro Era uma vez uma mulher que tentou matar o bebê da vizinha (2018), de Liudmila Petruchévskaia, à luz de compreender como estão presentes na obra da autora elementos oriundos de uma confluência de tradições literárias distintas, em especial aquela assinalada por Benjamin como a das narrativas da experiência, e como integrar tal tradição reconstitui a ameaça oriunda da transgressão de uma ideia de realidade que está no cerne da literatura fantástica tal qual observada pela categorização de David Roas.
REPRESENTAÇÕES DO MEDO NO CONTO “A CASA DOS MORTOS”, DE JÚLIA LOPES DE ALMEIDA
Authors: Knapp Cristina Loff , Guerra Gisele Troian , Moraes Raíssa
Published: April 2023

O objetivo deste artigo é analisar o conto “A casa dos mortos”, de Júlia Lopes de Almeida, que compõe a obra Ânsia eterna (2020), a fim de discutir a representação do medo e a caracterização do ambiente fantástico. Para tanto, utilizou-se as considerações teóricas, Delumeau (2009), Ceserani (2006), Bauman (2008), Campra (2016), França (2011 e 2012), Todorov (2017), a respeito do fantástico e do medo na literatura. A pesquisa será de revisão bibliográfica apoiada nos estudos teóricos do fantástico e dos estudos culturais de gênero. A autora, apesar de sua vasta publicação, ficou por muito tempo à margem da historiografia literária brasileira, e, ainda hoje, são poucos os estudos literários brasileiros que a citam. Dessa forma, é de fundamental relevância trazer à tona os estudos almeidianos, assim como as manifestações insólitas na literatura de autoria feminina.
A OPRESSÃO SENTIDA NOS CORPOS FEMININOS PELO VIÉS DE UMA LITERATURA GÓTICA BRASILEIRA
Authors: Oliveira Brito Mariana
Published: April 2023

Este estudo visa demonstrar, a partir da análise comparativa dos contos “As Rosas” (Ânsia eterna,1903) da escritora Júlia Lopes de Almeida, e do conto “Venha ver o pôr do sol”, da escritora Lygia Fagundes Telles, a literatura do medo aliada ao universo feminino dentro de uma perspectiva crítica por parte das escritoras, a fim de demonstrar suas críticas às violências às quais as mulheres foram submetidas por figuras masculinas patriarcais. A partir disso, a investigação terá como base os estudos sobre a literatura gótica a partir de Maurício Menon (2007); as observações da socióloga britânica Sylvia Theresa Walby (1990), que compreende o patriarcado como um modelo passível de transformações, assumindo diferentes graus ou formas; o livro História das mulheres no Brasil (2004), de Maria Del Priore; e as ideias de Gerda Lerner (2019). Com isso, pretendemos demonstrar, por meio da análise das personagens dos contos, como os homens constroem a ideia de feminilidade (encontros e desencontros) e o peso dessa construção sobre os corpos femininos diante das demandas da sociedade. Além disso, propõe-se apresentar uma proposta de ensino a partir do estudo dos contos para a sala de aula da educação básica.
USO DA DIVULGAÇÃO CIENTÍFICA PARA ENFRENTAMENTO DAS FAKE NEWS RELACIONADAS À COVID-19
Authors: Séllos Rodrigues Amanda , Lage Pessoa da Costa Flávia , Diniz Monteiro de Barros Marcelo
Published: April 2023

A divulgação científica e o jornalismo científico assumem um papel social de tornar o cidadão apto a entender e interferir no processo científico. Muitos estudantes podem encontrar dificuldade em identificar a informação verdadeira e a informação falsa, devido ao excesso de informações disponibilizadas na internet. Logo, a escola se torna um local que pode ajudar estes estudantes a desenvolver o senso crítico e a autonomia para detectar as fake news. O objetivo deste trabalho é apresentar três exemplos de atividades que envolvam a divulgação científica, o jornalismo científico e as fake news sobre a COVID-19 para se trabalhar com alunos do Ensino Fundamental - Anos Finais através das disciplinas de Ciências e Matemática. Acredita-se que as atividades apresentadas nesse trabalho potencializam o ensino de ciências e matemática, apresentando materiais diversificados e buscando aperfeiçoar o senso crítico dos estudantes frente às fake news sobre a COVID-19.
O PERFIL E A EVASÃO DAS AULAS DE EDUCAÇÃO FÍSICA NA PERSPECTIVA DOS ALUNOS DO ENSINO MÉDIO
Authors: Maffei Willer Soares , Dos Reis Gleyce Soares , Verardi Carlos Eduardo Lopes
Published: April 2023

Tem como objetivo compreender o perfil e o nível de participação dos alunos do 3° ano do Ensino Médio nas aulas de Educação Física.  Participaram do estudo 517 alunos de oito escolas públicas estaduais de um município do interior paulista. Para coleta de informações foi aplicado questionário com questões abertas e fechadas. Os resultados foram analisados por meio de estatística descritiva e análise de conteúdo e indicam atividades livres como núcleo central das aulas e experiências com o saber fazer e o saber sobre esse fazer, esses com menor destaque. Motivações pessoais e pedagógicas foram apontadas como causas para a evasão. Considera-se como urgente, perceber que, em momentos de crise e mudança, a educação física só se justificará na escola se tratar efetivamente de um saber específico que não pode ser menosprezado ou descaracterizado, de outra forma, corre o risco de ser excluída desse nível de ensino, conforme projeto em curso.
A EDUCAÇÃO DE JOVENS E ADULTOS NA COLÔMBIA E NO BRASIL: ENTRE 1990-2016
Authors: Maya Ana Lucia Medina , Ferreira Mônica Dias Peregrino
Published: April 2023

Nas últimas décadas, os países latino-americanos vêm atravessando um processo de transformações em seus sistemas sociais e educativos. Portanto, é necessário saber se as reformas de acesso, permanência e qualidade no ensino têm sido favoráveis para a Educação de Jovens e Adultos (EJA) e para os sujeitos que compõem essa modalidade, que no passado não tiveram a oportunidade de acessarem esses sistemas. Neste artigo, tentamos olhar as formas com que duas nações, Brasil e Colômbia, após os processos de redemocratização política e de expansão da educação, construíram os programas para esta população entre 1996 e 2016. O estudo foi realizado numa perspectiva comparativa entre as políticas educacionais que estruturam esta modalidade, passando pelo contexto histórico das reformas em que se desenvolveram os programas. Destacaremos, finalmente, os achados encontrados pela investigação ao longo do estudo.
DIRETRIZES CURRICULARES NACIONAIS PARA A EDUCAÇÃO DE JOVENS E ADULTOS: QUESTÕES SOBRE FORMAÇÃO, INCLUSÃO, EMANCIPAÇÃO E AUTONOMIA
Authors: Freitas Márcia Da Silva , Costa Valdelúcia Alves da
Published: April 2023

Este artigo vincula-se a uma tese de doutorado em educação em fase final de elaboração, tendo por objetivo central problematizar as questões referentes à educação de jovens e adultos na perspectiva da inclusão escolar, como também à negação e/ou banalização do direito à educação historicamente negado na sociedade de classes. Este estudo é conduzido à luz da Teoria Crítica da Sociedade, considerando os desafios impostos pelos limites sociais à formação educacional e humana, com vistas à emancipação e autonomia de estudantes jovens e adultos, tendo como referência as Diretrizes Curriculares Nacionais para a Educação de Jovens e Adultos (BRASIL, 2000), implementadas com o intuito de orientar a organização curricular das unidades escolares que ministram a Educação de Jovens e Adultos como modalidade de ensino.
VINTE ANOS DEPOIS: DESAFIOS DA EJA NA FORMAÇÃO DOS JOVENS NO CONTEXTO DA DUALIDADE ESTRUTURAL
Authors: Boanafina Anderson Teixeira , Hilário Sandro Marcelo , Boanafina Lilian Soares
Published: April 2023

Ao estabelecer reflexões sobre os vinte anos das Diretrizes Curriculares Nacionais para a Educação de Jovens e Adultos, este artigo aborda a juvenilização da EJA como um fenômeno que precisa ser estudado e compreendido no contexto de uma sociedade marcada pela dualidade estrutural, um processo-movimento histórico e complexo, que se alimenta das condicionantes necessárias à sobrevivência do ser humano, incluindo o trabalho e a educação. O artigo se vale dos fundamentos do materialismo histórico-dialético como eixo-norteador, apoiado por autores sobre o tema, na busca por desvelar as conexões entre o objeto em estudo e a estrutura da nossa sociedade.
REFERÊNCIAS VIVIOGRÁFICAS NA EDUCAÇÃO DE JOVENS E ADULTOS: DAS DIRETRIZES AO LETRAMENTO
Authors: Pinheiro Laís Lemos Silva Novo
Published: April 2023

O uso de referências é uma prática recorrente no campo das pesquisas por garantirem maior credibilidade. No caso deste estudo em desenvolvimento, intenciona-se demonstrar as potencialidades de referências advindas de vivências, um embasamento por experiência de vida, a partir de narrativas de memórias inspiradas pela literatura em turmas da Educação de Jovens e Adultos (EJA) de uma escola pública de São Gonçalo/RJ. Através de um diálogo entre a memória da história da EJA e suas diretrizes ante avanços e impasses, e as memórias dos próprios alunos dessa modalidade de ensino, espera-se promoção de autoria discente, por meio de letramento literário. A pesquisa se desenrola pela interação das contribuições das referências bibliográficas da área, como Freire, Haddad e Di Pierro, Ecléa Bosi, Cosson entre outros, e das referências viviográficas, ou seja, os próprios atores da pesquisa, os alunos da EJA.