bluuebunny/crossref_metadata_2025 huggingface dataset:
Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report
Authors: Tsaknis George , Naeem Muhammad , Singh Advitya , Vijayakumar Siddharth
Published: July 2021

Background

Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare.

Case presentation

A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later.

Conclusions

Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.
Mesenchymal stem cell transplantation for vaginal repair in an ovariectomized rhesus macaque model
Authors: Zhang Ye , Ma Yidi , Chen Juan , Wang Min , Cao Yuan , Li Lei , Yang Hua , Liu Xudong , Li Yaqian , Zhu Lan
Published: July 2021

Background

Current surgical therapies for pelvic organ prolapse (POP) do not repair weak vaginal tissue and just provide support; these therapies may trigger severe complications. Stem cell-based regenerative therapy, due to its ability to reconstruct damaged tissue, may be a promising therapeutic strategy for POP. The objective of this study is to evaluate whether mesenchymal stem cell (MSC) therapy can repair weak vaginal tissue in an ovariectomized rhesus macaque model.

Methods

A bilateral ovariectomy model was established in rhesus macaques to induce menopause-related vaginal injury. Ten bilaterally ovariectomized rhesus macaques were divided into two groups (n=5/group): the saline group and the MSC group. Three months after ovariectomy, saline or MSCs were injected in situ into the injured vaginal wall. The vaginal tissue was harvested 12 weeks after injection for histological and biochemical analyses to evaluate changes of extracellular matrix, microvascular density, and smooth muscle in the vaginal tissue. Biomechanical properties of the vaginal tissue were assessed by uniaxial tensile testing. Data analysis was performed with unpaired Student’s t test or Mann-Whitney.

Results

Twelve weeks after MSC transplantation, histological and biochemical analyses revealed that the content of collagen I, elastin, and microvascular density in the lamina propria of the vagina increased significantly in the MSC group compared with the saline group. And the fraction of smooth muscle in the muscularis of vagina increased significantly in the MSC group. In addition, MSC transplantation improved the biomechanical properties of the vagina by enhancing the elastic modulus.

Conclusion

Vaginal MSC transplantation could repair the weak vaginal tissue by promoting extracellular matrix ingrowth, neovascularization, and smooth muscle formation and improve the biomechanical properties of the vagina, providing a new prospective treatment for POP.
Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model
Authors: Li Yanhong , Shi Guiying , Han Yunlin , Shang Haiquan , Li Huiwu , Liang Wei , Zhao Wenjie , Bai Lin , Qin Chuan
Published: July 2021

Background

Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS is associated with serious cardiovascular disease and remains the leading cause of mortality worldwide. Mesenchymal stem cells (MSCs) have evolved as an attractive therapeutic agent in various diseases including AS. Human umbilical cord MSCs (UCSCs) have been used in cell therapy trials due to their ability to differentiate and proliferate. The present study aimed to investigate the effect of UCSCs treatment on atherosclerotic plaque formation and the progression of lesions in a high-fat diet rabbit model.

Methods

Rabbits were fed a high-fat diet and then randomly divided into three groups: control, model, and treatment groups. Rabbits in the treatment group were injected with UCSCs (6 × 106 in 500 μL phosphate buffered saline) after 1 month of high-fat diet, once every 2 weeks, for 3 months. The model group was given PBS only. We analyzed serum biomarkers, used ultrasound and histopathology to detect arterial plaques and laser Doppler imaging to measure peripheral blood vessel blood filling, and analyzed the intestinal flora and metabolism.

Results

Histological analysis showed that the aortic plaque area was significantly reduced in the treatment group. We also found a significant decrease in macrophage accumulation and apoptosis, an increase in expression of scavenger receptors CD36 and SRA1, a decrease in uptake of modified low–density protein (ox-LDL), and a decrease in levels of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α following UCSCs treatment. We also found that anti-inflammatory cytokines IL-10 and transforming growth factor (TGF)-β expression increased in the aorta atherosclerotic plaque of the treatment group. UCSCs treatment improved the early peripheral blood filling, reduced the serum lipid level, and inhibited inflammation progression by regulating the intestinal flora dysbiosis caused by the high-fat diet. More specifically, levels of the microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) were down-regulated in the treatment group.

Conclusions

UCSCs treatment alleviated atherosclerotic plaque burden by reducing inflammation, regulating the intestinal flora and TMAO levels, and repairing the damaged endothelium.
A new blow up criterion for the 3D magneto-micropolar fluid flows without magnetic diffusion
Authors: Chen Dongxiang , Liu Qifeng
Published: July 2021

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How have people been coping during the COVID-19 pandemic? Patterns and predictors of coping strategies amongst 26,016 UK adults
Authors: Fluharty Meg , Fancourt Daisy
Published: July 2021

Background

Individuals face increased psychological distress during the COVID-19 pandemic. However, it’s unknown whether choice of coping styles are influenced by COVID-19 in addition to known predictors.

Methods

Data from 26,016 UK adults in the UCL COVID-19 Social Study were analysed from 12/4/2020 15/5/2020. Regression models were used to identify predictors of coping styles (problem-focused, emotion-focused, avoidant, and socially-supported): model 1 included sociodemographic variables, model 2 additionally included psychosocial factors, and model 3 further included experience of COVID-19 specific adverse worries or events.

Results

Sociodemographic and psychosocial predictors of coping align with usual predictors of coping styles not occurring during a pandemic. However, even when controlling for the wide range of these previously known predictors specific adversities were associated with use of specific strategies. Experience of worries about finances, basic needs, and events related to Covid-19 were associated with a range of strategies, while experience of financial adversities was associated with problem-focused, emotion-focused and avoidant coping. There were no associations between coping styles and experiencing challenges in meeting basic needs, but Covid-19 related adversities were associated with a lower use of socially-supported coping.

Conclusions

This paper demonstrates that there are not only demographic and social predictors of coping styles during the COVID-19 pandemic, but specific adversities are related to the ways that adults cope. Furthermore, this study identifies groups at risk of more avoidant coping mechanisms which may be targeted for supportive interventions.
Development of a pediatric obstructive sleep apnea triage algorithm
Authors: Heath D. S. , El-Hakim H. , Al-Rahji Y. , Eksteen E. , Uwiera T. C. , Isaac A. , Castro-Codesal M. , Gerdung C. , Maclean J. , Mandhane P. J.
Published: July 2021

Introduction

Diagnosis and treatment of obstructive sleep apnea (OSA) in children is often delayed due to the high prevalence and limited physician and sleep testing resources. As a result, children may be referred to multiple specialties, such as pediatric sleep medicine and pediatric otolaryngology, resulting in long waitlists.

Method

We used data from our pediatric OSA clinic to identify predictors of tonsillectomy and/or adenoidectomy (AT). Before being seen in the clinic, parents completed the Pediatric Sleep Questionnaire (PSQ) and screening questionnaires for restless leg syndrome (RLS), nasal rhinitis, and gastroesophageal reflux disease (GERD). Tonsil size data were obtained from patient charts and graded using the Brodsky-five grade scale. Children completed an overnight oximetry study before being seen in the clinic, and a McGill oximetry score (MOS) was assigned based on the number and depth of oxygen desaturations. Logistic regression, controlling for otolaryngology physician, was used to identify significant predictors of AT. Three triage algorithms were subsequently generated based on the univariate and multivariate results to predict AT.

Results

From the OSA cohort, there were 469 eligible children (47% female, mean age = 8.19 years, SD = 3.59), with 89% of children reported snoring. Significant predictors of AT in univariate analysis included tonsil size and four PSQ questions, (1) struggles to breathe at night, (2) apneas, (3) daytime mouth breathing, and (4) AM dry mouth. The first triage algorithm, only using the four PSQ questions, had an odds ratio (OR) of 4.02 for predicting AT (sensitivity = 0.28, specificity = 0.91). Using only tonsil size, the second algorithm had an OR to predict AT of 9.11 (sensitivity = 0.72, specificity = 0.78). The third algorithm, where MOS was used to stratify risk for AT among those children with 2+ tonsils, had the same OR, sensitivity, and specificity as the tonsil-only algorithm.

Conclusion

Tonsil size was the strongest predictor of AT, while oximetry helped stratify individual risk for AT. We recommend that referral letters for snoring children include graded tonsil size to aid in the triage based on our findings. Children with 2+ tonsil sizes should be triaged to otolaryngology, while the remainder should be referred to a pediatric sleep specialist.

Graphical Abstract
Scaling-up production of plant endophytes in bioreactors: concepts, challenges and perspectives
Authors: Ganeshan Seedhabadee , Kim Seon Hwa , Vujanovic Vladimir
Published: July 2021

The benefit of microorganisms to humans, animals, insects and plants is increasingly recognized, with intensified microbial endophytes research indicative of this realization. In the agriculture industry, the benefits are tremendous to move towards sustainable crop production and minimize or circumvent the use of chemical fertilizers and pesticides. The research leading to the identification of potential plant endophytes is long and arduous and for many researchers the challenge is ultimately in scale-up production. While many of the larger agriculture and food industries have their own scale-up and manufacturing facilities, for many in academia and start-up companies the next steps towards production have been a stumbling block due to lack of information and understanding of the processes involved in scale-up fermentation. This review provides an overview of the fermentation process from shake flask cultures to scale-up and the manufacturing steps involved such as process development optimization (PDO), process hazard analysis (PHA), pre-, in- and post-production (PIP) challenges and finally the preparation of a technology transfer package (TTP) to transition the PDO to manufacturing. The focus is on submerged liquid fermentation (SLF) and plant endophytes production by providing original examples of fungal and bacterial endophytes, plant growth promoting Penicillium sp. and Streptomyces sp. bioinoculants, respectively. We also discuss the concepts, challenges and future perspectives of the scale-up microbial endophyte process technology based on the industrial and biosafety research platform for advancing a massive production of next-generation biologicals in bioreactors.
Soil carbon and nutrient stocks under Scots pine plantations in comparison to European beech forests: a paired-plot study across forests with different management history and precipitation regimes
Authors: Diers Marco , Weigel Robert , Culmsee Heike , Leuschner Christoph
Published: July 2021

Background

Organic carbon stored in forest soils (SOC) represents an important element of the global C cycle. It is thought that the C storage capacity of the stable pool can be enhanced by increasing forest productivity, but empirical evidence in support of this assumption from forests differing in tree species and productivity, while stocking on similar substrate, is scarce.

Methods

We determined the stocks of SOC and macro-nutrients (nitrogen, phosphorus, calcium, potassium and magnesium) in nine paired European beech/Scots pine stands on similar Pleistocene sandy substrates across a precipitation gradient (560–820 mm∙yr− 1) in northern Germany and explored the influence of tree species, forest history, climate, and soil pH on SOC and nutrient pools.

Results

While the organic layer stored on average about 80% more C under pine than beech, the pools of SOC and total N in the total profile (organic layer plus mineral soil measured to 60 cm and extrapolated to 100 cm) were greater under pine by about 40% and 20%, respectively. This contrasts with a higher annual production of foliar litter and a much higher fine root biomass in beech stands, indicating that soil C sequestration is unrelated to the production of leaf litter and fine roots in these stands on Pleistocene sandy soils. The pools of available P and basic cations tended to be higher under beech. Neither precipitation nor temperature influenced the SOC pool, whereas tree species was a key driver. An extended data set (which included additional pine stands established more recently on former agricultural soil) revealed that, besides tree species identity, forest continuity is an important factor determining the SOC and nutrient pools of these stands.

Conclusion

We conclude that tree species identity can exert a considerable influence on the stocks of SOC and macronutrients, which may be unrelated to productivity but closely linked to species-specific forest management histories, thus masking weaker climate and soil chemistry effects on pool sizes.
CA19-9-producing esophageal adenocarcinoma originating from the esophageal cardia of the mid-thoracic esophagus: a case report
Authors: Kuwayama Naoki , Hoshino Isamu , Gunji Hisashi , Kurosaki Takeshi , Tonooka Toru , Soda Hiroaki , Sonoda Itaru , Eto Ryotaro , Takiguchi Nobuhiro , Nabeya Yoshihiro , Itami Makiko , Takayama Wataru
Published: July 2021

Background

Although there are many studies on primary esophageal adenocarcinoma arising from Barrett's esophagus or ectopic gastric mucosa, reports on adenocarcinoma arising from esophageal cardiac glands are extremely rare. Herein, we report a case of mid-thoracic cancer antigen 19-9 (CA 19-9)-producing primary esophageal adenocarcinoma, which presumably originated from the cardiac glands.

Case presentation

A 74-year-old man was referred to our department with advanced esophageal cancer, which initially presented with dyspepsia. Serum levels of cancer antigen 19-9 (CA 19-9) were elevated (724.89 U/ml). Upper gastrointestinal endoscopy revealed a type 2 tumor on the posterior wall of the mid-thoracic esophagus approximately 29–32 cm from the incisor. Mucosal biopsy was consistent with a diagnosis of adenocarcinoma. Contrast-enhanced computed tomography showed a circumferential wall thickening in the mid-thoracic esophagus without enlarged lymph nodes or distant metastasis. Positron emission tomography–computed tomography showed accumulation in the primary tumor, but no evidence of lymph node or distant metastasis. According to these findings, the adenocarcinoma was staged as cT3N0M0, thereby, requiring subtotal esophagectomy with lymph node dissection. Postoperative course was uneventful. Histopathologic analysis revealed a 50 × 40 mm moderately differentiated adenocarcinoma with invasion to the thoracic duct and lymph node metastasis at #108(1/4), #109R(1/3), and #109L(1/3). After surgery, the stage was revised to moderately differentiated pT4apN2pM0 (pStage III). Immunostaining revealed expression of CA19-9 and suggested esophageal cardiac gland origin of the tumor. Three months after the surgery, the patient showed no recurrence and is undergoing outpatient observation.

Conclusions

We experienced a case of mid-thoracic CA19-9-producing primary esophageal adenocarcinoma, which was presumed to have originated in the esophageal cardiac glands. Due to the scarcity of studies regarding this condition, specific management needs to be further clarified.
Maximal muscular power: lessons from sprint cycling
Authors: Douglas Jamie , Ross Angus , Martin James C.
Published: July 2021

Maximal muscular power production is of fundamental importance to human functional capacity and feats of performance. Here, we present a synthesis of literature pertaining to physiological systems that limit maximal muscular power during cyclic actions characteristic of locomotor behaviours, and how they adapt to training. Maximal, cyclic muscular power is known to be the main determinant of sprint cycling performance, and therefore we present this synthesis in the context of sprint cycling. Cyclical power is interactively constrained by force-velocity properties (i.e. maximum force and maximum shortening velocity), activation-relaxation kinetics and muscle coordination across the continuum of cycle frequencies, with the relative influence of each factor being frequency dependent. Muscle cross-sectional area and fibre composition appear to be the most prominent properties influencing maximal muscular power and the power-frequency relationship. Due to the role of muscle fibre composition in determining maximum shortening velocity and activation-relaxation kinetics, it remains unclear how improvable these properties are with training. Increases in maximal muscular power may therefore arise primarily from improvements in maximum force production and neuromuscular coordination via appropriate training. Because maximal efforts may need to be sustained for ~15-60 s within sprint cycling competition, the ability to attenuate fatigue-related power loss is also critical to performance. Within this context, the fatigued state is characterised by impairments in force-velocity properties and activation-relaxation kinetics. A suppression and leftward shift of the power-frequency relationship is subsequently observed. It is not clear if rates of power loss can be improved with training, even in the presence adaptations associated with fatigue-resistance. Increasing maximum power may be most efficacious for improving sustained power during brief maximal efforts, although the inclusion of sprint interval training likely remains beneficial. Therefore, evidence from sprint cycling indicates that brief maximal muscular power production under cyclical conditions can be readily improved via appropriate training, with direct implications for sprint cycling as well as other athletic and health-related pursuits.
The treatment dilemma in adult patients with peripheral pulmonary artery stenosis of diverse etiologies
Authors: Hosseini Zahra , Firouzi Ata , Mohebbi Bahram , Khalilipur Ehsan , Baay Mohammadreza , Kalantari Kiara Rezaei , Harirforoosh Iman , Khajali Zahra
Published: July 2021

Background

Peripheral pulmonary artery stenosis (PPAS) is a rare and underdiagnosed phenomenon that is reported infrequently in adult patients. Most patients with PPAS have concomitant congenital heart diseases, a history of palliative surgical therapies during childhood, or syndromic characteristics. Acquired cases are rare, and they are underestimated in adulthood and managed inappropriately.

Case presentation

This case series describes 3 adult patients with PPAS of diverse etiologies and discusses their underlying causes, diagnostic modalities, and treatment strategies.

Conclusions

In patients with PPAS, sufficient heed should be paid to endovascular interventions such as balloon dilation and primary or bailout stenting, not least vis-à-vis the type and size of balloons or stents as well as complications and preventive strategies.
Melanosis coli: a case report
Authors: K V Anoop
Published: July 2021

Background

Melanosis coli is a benign condition characterized by deposition of lipofuscin in colonic mucosa due to long-term laxative use.

Case presentation

Here I am reporting a case of an 85-year-old man who presented with constipation, with a history of long-term herbal medication intake as laxatives, and upon evaluation, he was found to have melanosis coli.

Conclusion

Melanosis coli is a common adverse effect of chronic laxative use which is more common in elderly population with constipation.
Effect of “Spatially Separated Speech in Noise Training” on speech perception in noise in children with bimodal fitting
Authors: Lotfi Younes , Hasanalifard Mahdieh , Moossavi Abdollah , Bakhshi Enayatollah , Ajalloueyan Mohammad
Published: July 2021

Background

The objective of this study was to evaluate the effect of “Spatially separated speech in noise” auditory training on the ability of speech perception in noise among bimodal fitting users.

The assumption was that the rehabilitation can enhance spatial hearing and hence speech in noise perception. This study was an interventional study, with a pre/post-design. Speech recognition ability was assessed with the specific tests. After performing the rehabilitation stages in the intervention group, the speech tests were again implemented, and by comparing the pre- and post-intervention data, the effect of auditory training on the speech abilities was assessed.

Twenty-four children of 8–12 years who had undergone cochlear implantation and continuously used bimodal fitting were investigated in two groups of control and intervention.

Results

The results showed a significant difference between the groups in different speech tests after the intervention, which indicated that the intervention group have improved more than the control group.

Conclusion

It can be concluded that “Spatially separated speech in noise” auditory training can improve the speech perception in noise in bimodal fitting users. In general, this rehabilitation method is useful for enhancing the speech in noise perception ability.
Reconstruction of distorted structures in the fault shadow zone based on the fully connected network
Authors: Yang Xiaojiang , Wen Xiaotao , Zhou Dongyong , Wang Yahui , Yan Zhenghe , Li Xiao
Published: July 2021

Lateral changes in velocity about faults can give rise to fault shadow (FS) zones on time-migrated data volumes, which can result in structural interpretation artifacts in the fault trap reservoir. To address this issue, we have adopted a new reconstruction method of FS distortion structures based on a deep learning fully connected network (FCN). We use the 3D stratigraphic dip attributes to quantitatively delineate the extent of the FS zone. Then, we train a model to construct a nonlinear trend surface based on the structures of the stratigraphic reflectors that fall outside of the shadow zone. Finally, we use this nonlinear trend surface to compensate for the distorted structure within the FS zone. We calibrate our method using synthetic data and find that the method can accurately recover structural data within the FS distortion zone. We then test the effectiveness of our workflow by applying it to recover real FS distortion structures in the Pearl River Mouth Basin of the South China Sea. The results confirm that our method significantly reduces drilling depth errors in the FS zone. Compared to the traditional polynomial fitting method, the multilayer, multiparameter, and flexible nonlinear activation function of FCN is more capable of reconstructing nonlinear geologic structures in the FS zone. We find the FCN-based geologic reconstruction method to be efficient and effective for exploring potential structures in the FS zone and thereby in avoiding the risks of structural failure.
Tumor Response End Points as Surrogates for Overall Survival in Immune Checkpoint Inhibitor Trials: A Systematic Review and Meta-Analysis
Authors: Kok Peey-Sei , Yoon Won-Hee , Lord Sally , Marschner Ian , Friedlander Michael , Lee Chee Khoon
Published: July 2021

PURPOSE

Many immune checkpoint inhibitors (ICIs) have been approved on the basis of tumor response end points in nonrandomized trials, including objective response rate (ORR) and duration and depth of response. We aimed to assess the validity of these end points as surrogate end points for overall survival (OS) in patients with advanced solid tumors treated with ICIs at trial and treatment arm levels.

METHODS

ICI trials in advanced solid cancers published between January 1, 2000, and March 31, 2020, were included. Correlations between ORR, durable response (DR) of ≥ 6 months, complete response (CR), and OS were assessed for treatment comparisons (trial-level) and for patients receiving ICI (arm-level), using weighted linear regression.

RESULTS

Sixty-three trials were eligible, including 58 randomized controlled trials and 20 nonrandomized controlled trials (78 ICI arms and 30,815 patients). The majority were phase III (63%), and OS was the most common primary end point (40%). In relative treatment comparisons, correlations between ORR risk ratio and OS hazard ratio (HR), 6-month DR ratio and OS HR, and CR ratio and OS HR were r = 0.58, r = 0.62, and r = 0.42, respectively. Exploratory studies in melanoma, non–small-cell lung cancer, and other tumors showed similar results, although 6-month DR ratio was strongly correlated with OS HR ( r = 0.89). Within ICI arms only, correlations between ORR and 12-month OS, 6-month DR and 12-month OS, and CR and 12-month OS were r = 0.76, r = 0.84, and r = 0.50, respectively, in all eligible trials.

CONCLUSION

Relative measures of tumor response (ORR, 6-month DR, and CR) are poor surrogate end points for OS in ICI studies. However, ORR and 6-month DR are prognostic of 12-month OS in ICI studies supporting their use for screening activity of novel agents in early-phase nonrandomized trials.
Ice speed skating: Onset of lubrication by frictional heating
Authors: van Dongen M. E. H. , Smeulders D. M. J.
Published: July 2021

In ice speed skating, the friction between the steel skate blade and the ice stems from boundary friction where the temperature of the interface is below zero and ice surface molecules exhibit unconventional mobility, and hydrodynamic friction where the ice melts and a thin water layer between the blade and the ice forms. An analytical solution of the steady-state lubrication equation shows that the boundary friction only plays a role at the tip of the skate blade over an extremely short contact length between the skate blade and the ice. Albeit its negligible contribution to total friction, boundary friction generates enough heat to melt the ice which allows the skater to slide smoothly on a thin layer of melt water. It is also shown that the precise value of the boundary friction coefficient is not important for speed skate friction because it works only over an extremely short contact length.
Dragon-king extreme events as precursors for catastrophic transition
Authors: Premraj D. , Suresh Kumarasamy , Pawar Samadhan A. , Kabiraj Lipika , Prasad Awadhesh , Sujith R. I.
Published: July 2021

Unexpected catastrophic transitions are often observed in complex systems. However, the prediction of such transitions is difficult in practice. Here, we find a special kind of extreme events with a dragon-king probability distribution that occur just prior to a catastrophic transition and, hence, can serve as its precursor. To illustrate the application of dragon kings as a precursor, we consider a practical experimental thermo-fluid system and a theoretical model of coupled logistic maps with quasi-periodic forcing, both systems displaying a catastrophic transition.
The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality
Authors: Acharya Prakash , Dalia Tarun , Ranka Sagar , Sethi Prince , Oni Olurinde A , Safarova Maya S , Parashara Deepak , Gupta Kamal , Barua Rajat S
Published: July 2021

Objective

The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D–deficient patients without a prior history of myocardial infarction (MI).

Materials and Methods

This was a retrospective, observational, nested case–control study of patients (N = 20 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (<20 ng/mL) who received care at the Veterans Health Administration from 1999 to 2018. Patients were divided into 3 groups: Group A (untreated, levels ≤20 ng/mL), Group B (treated, levels 21-29 ng/mL), and Group C (treated, levels ≥30 ng/mL). The risk of MI and all-cause mortality were compared utilizing propensity score–weighted Cox proportional hazard models.

Results

Among the cohort of 20 025 patients, the risk of MI was significantly lower in Group C than in Group B (hazard ratio [HR] 0.65, 95% CI 0.49-0.85, P = .002) and Group A (HR 0.73, 95% CI 0.55-0.96), P = .02). There was no difference in the risk of MI between Group B and Group A (HR 1.14, 95% CI 0.91-1.42, P = 0.24). Compared with Group A, both Group B (HR 0.59, 95% CI 0.54-0.63, P < .001) and Group C (HR 0.61, 95% CI 0.56-0.67, P < .001) had significantly lower all-cause mortality. There was no difference in all-cause mortality between Group B and Group C (HR 0.99, 95% CI 0.89-1.09, P = .78).

Conclusions

In patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/mL and >30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels ≥30 ng/mL.
The “Barbaric”Dabke
Authors: Silverstein Shayna
Published: July 2021

This essay analyzes how dance, gender, and state power function together as a significant node of critique in recent cultural production that addresses authoritarianism in Syria. Identifying the symbolic trope of dabke, a popular dance ubiquitous in Syrian life, selected films, literature, and choreography, this essay argues that the discussed works dislodge dabke from its feminized association with authenticity, folk culture, and nationhood to instead represent dabke as a form of hegemonic masculinity that perpetuates sovereignty, patriarchy, and autocracy. Through the rendering of embodied acts of dabke performance, hegemonic and resilient modes of masculinity are equated with spectacles of violence attached to the state, repressive tactics by the police state, and performative complicity with the regime. This essay argues that sovereign and autocratic forms of power are not universal abstractions but are embedded in the gendered structures of the society in which such power is performed.
A Black Intellectual's Odyssey
Authors: Kilson Martin
Published: July 2021

In 1969, Martin Kilson became the first tenured African American professor at Harvard University, where he taught African and African American politics for over thirty years. In A Black Intellectual's Odyssey, Kilson takes readers on a fascinating journey from his upbringing in the small Pennsylvania milltown of Ambler to his experiences attending Lincoln University—the country's oldest HBCU—to pursuing graduate study at Harvard before spending his entire career there as a faculty member. This is as much a story of his travels from the racist margins of twentieth-century America to one of the nation's most prestigious institutions as it is a portrait of the places that shaped him.

He gives a sweeping sociological tour of Ambler as a multiethnic, working-class company town while sketching the social, economic, and racial elements that marked everyday life. From narrating the area's history of persistent racism and the racial politics in the integrated schools to describing the Black church's role in buttressing the town's small Black community, Kilson vividly renders his experience of northern small-town life during the 1930s and 1940s.

At Lincoln University, Kilson's liberal political views coalesced as he became active in the local NAACP chapter. While at Lincoln and during his graduate work at Harvard, Kilson observed how class, political, and racial dynamics influenced his peers' political engagement, diverse career paths, and relationships with white people. As a young professor, Kilson made a point of assisting Harvard's African American students in adapting to life at a white institution.

Throughout his career, Kilson engaged in pioneering scholarship while mentoring countless students. A Black Intellectual's Odyssey features contributions from three of his students: a foreword by Cornel West and an afterword by Stefano Harney and Fred Moten.
No One's Witness
Authors: Zolf Rachel
Published: July 2021

In No One's Witness Rachel Zolf activates the last three lines of a poem by Jewish Nazi holocaust survivor Paul Celan—“No one / bears witness for the / witness”—to theorize the poetics and im/possibility of witnessing. Drawing on black studies, continental philosophy, queer theory, experimental poetics, and work by several writers and artists, Zolf asks what it means to witness from the excessive, incalculable position of No One. In a fragmentary and recursive style that enacts the monstrous speech it pursues, No One's Witness demonstrates the necessity of confronting the Nazi holocaust in relation to transatlantic slavery and its afterlives. Thinking along with black feminist theory's notions of entangled swarm, field, plenum, chorus, No One's Witness interrogates the limits and thresholds of witnessing, its dangerous perhaps. No One operates outside the bounds of the sovereign individual, hauntologically informed by the fleshly no-thingness that has been historically ascribed to blackness and that blackness enacts within, apposite to, and beyond the No One. No One bears witness to becomings beyond comprehension, making and unmaking monstrous forms of entangled future anterior life.
Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors
Authors: MORO TATIANA , TINSLEY GRANT , PACELLI FRANCESCO Q. , MARCOLIN GIUSEPPE , BIANCO ANTONINO , PAOLI ANTONIO
Published: July 2021

Introduction

Recently, a modified intermittent fasting protocol was demonstrated to be able to maintain muscle mass and strength, decrease fat mass, and improve some inflammation and cardiovascular risk factors in healthy resistance-trained males after 2 months. The present study sought to investigate the long-term effects on these parameters.

Methods

The experiment was a single-blind randomized study. Twenty healthy subjects were enrolled and underwent 12 months of either a time-restricted eating (TRE) diet or a normal diet (ND) protocol, along with resistance training. In the TRE protocol, subjects consumed their energy needs in three meals during an 8-h period of time each day (1 pm, 4 pm, and 8 pm). Subjects in the ND group also had three meals, which were consumed at 8 am, 1 pm, and 8 pm. Groups were matched for kilocalories consumed and macronutrient distribution at baseline.

Results

After 12 months of TRE, body mass, fat mass, insulin-like growth factor 1, and testosterone were significantly lower compared with ND. Moreover, inflammatory markers (interleukin 6, interleukin 1β, and tumor necrosis factor α), insulin sensitivity (fasting glucose, insulin, and homeostatic model assessment for insulin resistance index), and lipid profile (cholesterol, HDL, and LDL) significantly improved after TRE compared with ND. Finally, subjects in TRE spontaneously decreased their daily energy intake, whereas those in ND maintained their starting kilocalories per day. No adverse events were reported.

Conclusions

Our results suggest that long-term TRE combined with a resistance training program is feasible, safe, and effective in reducing inflammatory markers and risk factors related to cardiovascular and metabolic diseases.
Tanner–Whitehouse and Modified Bayley–Pinneau Adult Height Predictions in Elite Youth Soccer Players from the Middle East
Authors: LOLLI LORENZO , JOHNSON AMANDA , MONACO MAURICIO , CARDINALE MARCO , DI SALVO VALTER , GREGSON WARREN
Published: July 2021

Purpose

To provide the first scrutiny of adult height prediction protocols based on automated Greulich–Pyle and Tanner–Whitehouse (TW) skeletal ages applied to elite youth soccer players from the Middle East.

Methods

We examined the application of modified Bayley–Pinneau (BoneXpert®), TW-II, and TW-III protocols using mixed-longitudinal data available for 103 subjects (chronological age range, 19.4 to 27.9 yr) previously enrolled as academy student-athletes (annual screening range, one to six visits). Random-effects generalized additive models quantified the presence of systematic mean differences between actual versus predicted adult height. Effects were deemed practically equivalent based on the location of the confidence interval (95% CI) against a realistic difference value of Δ = ± 1 cm. Each model pooled residual standard deviation described the actual precision of height predictions and was used to calculate a 95% prediction interval.

Results

The BoneXpert® method overpredicted adult height systematically at chronological ages in the range of approximately 13.5 to 14.5 yr (95% CI range, −1.9 to −1 cm) and Greulich–Pyle skeletal ages between 13.5 and 15 yr (95% CI range, −3.1 to −1 cm). Effects based on TW-II were practically equivalent across the chronological and skeletal age measurement ranges, with this protocol yielding adult height predictions with a precision (standard deviation) of approximately ±2.6 cm. The mean TW-III effects indicated systematic adult height overpredictions until the attainment of 14.5 and 15 yr of chronological age (95% CI range, −3.8 to −1.1 cm) and TW-III skeletal age (95% CI range: −5.2 to −2.3 cm), respectively.

Conclusions

Tanner–Whitehouse-II adult height prediction method provided more consistent estimates and can be considered the method of choice for talent development purposes in youth soccer players from the Middle East.
Genetic and Environmental Effects on the Individual Variation and Continuity of Participation in Diverse Physical Activities
Authors: KAARTINEN SARA , SILVENTOINEN KARRI , KORHONEN TELLERVO , KUJALA URHO M. , KAPRIO JAAKKO , AALTONEN SARI
Published: July 2021

Introduction

Participation in diverse physical activities has beneficial health effects. However, little is known on how genetic and environmental factors affect this trait. Thus, we examined to what extent these factors explain participation in diverse leisure-time physical activities from late adolescence to adulthood using a twin study design.

Methods

The participants were Finnish twins who reported their participation in diverse leisure-time physical activities at ages 17 (n = 5429) and 34 yr (n = 4246). The number of physical activities engaged in was analyzed using applications of structural linear modeling for twin data.

Results

On average, the total number of physical activities engaged in during leisure time was slightly over three at both ages and in both sexes, with moderate heritability estimates (40%–58%) from adolescence to adulthood. Environmental factors shared by co-twins (e.g., childhood family environment) influenced only in adolescence, being higher for women. Environmental influences unique to each co-twin explained the remaining variances (34%–57%), being higher at age 34 yr. Participation in diverse leisure-time physical activities correlated moderately between ages 17 and 34 yr (men: r
trait = 0.30, 95% confidence interval [CI] = 0.25–0.35; women: r
trait = 0.26, 95% CI = 0.22–0.31). In addition, genetic influences on participation in physical activities correlated moderately between adolescence and adulthood (r
A = 0.51, 95% CI = 0.39–0.64, and 0.44, 95% CI = 0.34–0.55, respectively). These common genetic influences explained 93% of the trait correlations found in men and 85% in women.

Conclusions

Genetic and unique environmental influences explain a large proportion of variation in the number of leisure-time physical activities. However, the estimates vary by age and sex. Common genetic background mainly explains the continuity of the participation in diverse leisure-time physical activities between adolescence and adulthood.
SWAT 76 evaluation: randomised evaluation of sending pre-notification cards to trial participants before a face-to-face primary outcome measurement to increase attendance
Authors: Treweek Shaun , Gallant Stephanie , Anderson Annie S.
Published: July 2021

Background: Retention is considered the second highest trial methods priority in the UK after recruitment.

  Methods: This Study Within A Trial (SWAT) evaluated whether sending a pre-notification card around one month before a face-to-face primary outcome measurement visit compared to not sending the card increased trial retention. The SWAT was a two-arm, parallel randomised (1:1 allocation ratio), stratified by centre, study. It was embedded within the ActWELL host trial, which evaluated whether women receiving lifestyle change counselling from volunteer coaches improved outcomes including weight and physical activity.

The SWAT primary outcome was the difference in the proportion of participants attending the host trial primary outcome measurement visit. The secondary outcome was the direct cost of sending cards. Host trial participants and research staff at the primary outcome visit were blind to the SWAT. Analysis was intention-to-treat. Certainty of evidence was assessed using GRADE.

Results: 558 host trial participants took part in the SWAT and were included in the analysis. Of the 274 women sent a card, 231 attended the primary outcome visit (84.3%) compared to 230/284 (81.0%) for those not receiving a card. Sending a pre-notification card may result in a slight increase in attendance at a face-to-face primary outcome measurement visit at 1-year: risk difference = 3.3% (95% confidence interval = -3.0% to 9.6%). This is GRADE low certainty evidence. A recording error meant it was unclear whether 17 participants allocated to the card were actually sent one but a sensitivity analysis did not change the overall result or conclusion. The direct cost of producing and sending the cards was £192 GBP (€213 EUR; $260 USD), or £21.33 (€23.55; $28.77 per additional retained participant.

  Discussion: Trialists could consider using pre-notification as they may gain a slight increase in retention to face-to-face trial measurement visits but further evaluations are needed.
Depression among pet owners and non-pet owners: a comparative cross-sectional study in Dhaka, Bangladesh
Authors: Chakma Samar Kishor , Islam Taswib Tajwar , Shahjalal Md. , Mitra Dipak Kumar
Published: July 2021

Background: Depression is a major contributor to overall global disease burden, often beginning in the teenage years and continuing into later life. Previous studies have reported high global rates of depression during these formative years, including in Bangladesh. At the same time, the therapeutic effect that pet ownership can have on depression is increasingly being recognized. However, studies examining these effects in Bangladesh are scarce. This study examined the association between household pet ownership and depression among people older than 13 years in Dhaka, Bangladesh.

Methods: A cross-sectional study was conducted using online and offline approaches. We used a snowball sampling technique to identify pet owners aged greater than 13 years residing in Dhaka, Bangladesh. Both web-based survey questionnaires using social media and hard copies were used to collect data from urban-dwelling pet owners. Logistic regression was used to identify the independent role of pet ownership in depression, adjusting for confounders including age, sex, marital status, known chronic disabilities, and other variables.

Results: A total of 140 pet owners and an equal number of non-pet owners participated in the study. Pet owners were found to be 41% less depressed than non-pet owners (AOR: 0.59; 95% CI: 0.31–1.14). In addition, males (AOR: 3.38; 95% CI: 1.50–7.62) who were either unmarried (AOR: 2.10; 95% CI: 1.05–4.16), smoked tobacco (AOR: 5.27; 95% CI: 1.50–18.53), or had a physical disability (AOR: 5.27; 95% CI: 1.50–18.53) were significantly more likely to be depressed.

Conclusion: Regression analysis revealed that in Dhaka, pet owners were associated with lower levels of depression compared to non-pet owners.

Keywords: Pets and depression, animal-assisted activities, pets and mental health, pets and psychological health.
Naïve, unenculturated chimpanzees fail to make and use flaked stone tools
Authors: Bandini Elisa , Motes-Rodrigo Alba , Archer William , Minchin Tanya , Axelsen Helene , Hernandez-Aguilar Raquel Adriana , McPherron Shannon P. , Tennie Claudio
Published: July 2021

Background: Despite substantial research on early hominin lithic technologies, the learning mechanisms underlying flake manufacture and use are contested. To draw phylogenetic inferences on the potential cognitive processes underlying the acquisition of both of these abilities in early hominins, we investigated if and how one of our closest living relatives, chimpanzees (Pan troglodytes), could learn to make and use flakes.

Methods: Across several experimental conditions, we tested eleven task-naïve chimpanzees (unenculturated n=8, unknown status n=3) from two independent populations for their abilities to spontaneously make and subsequently use flakes as well as to use flakes made by a human experimenter.

Results: Despite the fact that the chimpanzees seemed to understand the requirements of the task, were sufficiently motivated and had ample opportunities to develop the target behaviours, none of the chimpanzees tested made or used flakes in any of the experimental conditions.

Conclusions: These results differ from all previous ape flaking experiments, which found flake manufacture and use in bonobos and one orangutan. However, these earlier studies tested human-enculturated apes and provided test subjects with flake making and using demonstrations. The contrast between these earlier positive findings and our negative findings (despite using a much larger sample size) suggests that enculturation and/or demonstrations may be necessary for chimpanzees to acquire these abilities. The data obtained in this study are consistent with the hypothesis that flake manufacture and use might have evolved in the hominin lineage after the split betweenHomoandPan7 million years ago, a scenario further supported by the initial lack of flaked stone tools in the archaeological record after this split. We discuss possible evolutionary scenarios for flake manufacture and use in both non-hominin and hominin lineages.