bluuebunny/crossref_metadata_2025 huggingface dataset:
The Clinico-Hematological assessment and feto-maternal outcome of pancytopenia during pregnancy
Authors: SINGH SHOBHANA , FUKE RUJUTA , RACHWANI KIRTI
Published: April 2023

Introduction: Pancytopenia is defined as decrease in all three cellular elements of peripheral blood leading to anemia, leucopenia and thrombocytopenia1.Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dyspnea, and bleeding, bruising and increased tendency to infections2. The most common causes leading to pancytopenia on bone marrow examination are hypoplastic/aplastic bone marrow (29.05%), megaloblastic anemia (23.64%), hematological malignancies i.e. acute myeloid leukemia (21.62%), and erythroid hyperplasia (19.6%).3 The commonest clinical manifestations of pancytopenia are usually fever (86.7%), fatigue (76%), dizziness (64%), weight loss (45.3%), anorexia (37.3%), night sweats (28%), pallor (100%), bleeding (38.7%), and spleenomegaly (48%). A pregnancy complicated by severe AA is a great challenge for obstetricians.4,5
Objective: To assess the clinico-hematological parameters and & fetal outcomes among pregnant mothers with pancytopenia.
Methods: Pregnant mothers with pancytopenia visiting ANC OPD or admitted patients were enrolled into the study with sample size of 96. Written informed consent was taken and study design explained to them, and the investigations were done and data was collected.
Results and discussion: subjects presented with symptoms of pancytopenia like pallor, bleeding diathesis, fatigue and fever, glossitis cheilosis. Platelet count of 30 % of subjects were in the range of 71000 to 90000. 32.3 % mothers had megaloblastic anaemia, Aplastic anaemia was present in 18.7 % and pregnancy induced hypertension in 14.7 % subjects, and eclampsia in 5.2 % subjects.
Conclusion: Association of pancytopenia with pregnancy is a rare entity yet it has increased risk of adverse maternal and foetal outcome. Early diagnosis and intervention bring favourable maternal and foetal outcome. This study identified the risk factors of mortality and morbidity in pregnant women with severe aplastic anaemia as well as the obstetrical complications associated with neonatal outcome.
Key words: AA-Aplastic anaemia
Lymphoma-associated Hemophagocytic Syndrome: Case Report of a Natural Killer
Authors: Bastos Martim , Machado Andreia , Monteiro Ana , Dias Ana , Moura Anne , Mousinho Filipa , Antunes In
Published: April 2023

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening clinical syndrome, caused by an unregulated activation of cytotoxic T cells and macrophages. In adult patients, it is generally triggered by an underlying disease, with a significant proportion of cases being associated with malignancies (mainly lymphoma). The triad of fever, cytopenias, and hepatosplenomegaly is usually present, but, in severe cases, most patients will have a syndrome resembling sepsis and multiple organ failure, requiring admission into a critical care unit.

We present a case of a 33-year-old healthy male patient, who presented with fever, malaise, and lower gastrointestinal bleeding. Upon admission, he was hypotensive and had elevated inflammatory markers, pancytopenia, and liver damage. Due to worsening shock of presumed septic and hemorrhagic origin, he was admitted to our ICU. An extensive diagnostic work-up was performed, including a bone marrow aspirate that revealed active hemophagocytosis and pleural effusion analysis that revealed abundant NK-Cells, phenotypically compatible with aggressive NK-Cell lymphoma. Anti-inflammatory and neoplastic treatments were immediately initiated, with a partial and transient response. Nonetheless, he developed refractory shock and medullary aplasia and died twenty days after being admitted.

Although it is uncommon in adults, HLH is an important sepsis differential diagnosis to be aware of because it necessitates specific and timely treatment. Further investigation to determine and treat the possible underlying causes, including occult malignancies, is of paramount importance.
A Rare Case of Testicular Infarction Secondary to Epididymo-Orchitis in a Patient with Spinal Cord Injury
Authors: Chang Victor , Ho Tiffany , Ho Quangvy , Leong Kevin
Published: April 2023

There has been an increasing number of reported cases of testicular infarction secondary to epididymo-orchitis in recent years. However, the occurrence of this in those with spinal cord injuries has rarely been reported. This population of patients have a higher prevalence of epididymo-orchitis and due to altered or absent nociceptive perception, evaluation of their progression to testicular infarction can be difficult, leading to unnecessary delay for surgical management. We present a case of epididymo-orchitis in a patient with C5/6 complete spinal cord injury whose clinical course was complicated by testicular infarction requiring left orchidectomy. This case highlights those with spinal cord injuries may benefit from increased vigilance, more frequent imaging surveillance and consideration of adjunct imaging modalities to monitor the progression of epididymo-orchitis and facilitate earlier diagnosis of complications.
Cross-cultural Research of the Perceived Risk During the COVID-19 Pandemic
Authors: Krumov Krum , Schneider Johann F. , Liu Jin , Krumova Albena K. , Widodo Eko Widodo , Gungov Alexander  L. , Juhasz Marta , Garvanova Magdalena Z. , Kumar Sanjay , Repaczki Rita
Published: April 2023

One of the essential aspects in analyzing the topic of managing people's risk behavior in extreme situations is related to the issue of risk perception. The subject of this study was to reveal whether certain factors, such as cultural context, gender, age, education, religious beliefs, etc., mediate the perceived risk during the COVID-19 pandemic. The study was conducted online from April to June 2020. The two samples included a total of 2617 participants aged between 18 and 70 years, where 1412 of which were drawn from Asia and 1205 were representatives of Europe. Participants were asked to complete an internet-based version of a short questionnaire that described the COVID-19 pandemic situation, as one of the questions referred to the hazard perception of the infection. Results obtained showed that there was a higher level of perceived risk among members of the Asian culture group in comparison with the European study participants. Furthermore, it was revealed that gender is not a significant factor in the perception of risk in either the European or the Asian cultural group (p> 0.05). The results showed that levels of the perceived risk increased with age and that there were significant differences between young and old in threat perception for the European sample (p<0.001). Regarding the Asian sample, it turned out that all age groups perceive the risk of infection almost equally. Several demographic characteristics also emerged as important mediators of risk perception. For example, people with the lowest education, married, religious, and families with children fear the hazard of COVID-19 infection to the greatest extent, compared to people with the highest education, singles, atheists, and families without children, who do not perceive the virus as a high-risk factor.
A Systematic Literature Review on Financial Support for the Development of Strategic Emerging Industries
Authors: Xu Su-juan , Zhang Mu
Published: April 2023

In order to further promote the theoretical research on the effective financial support for the high-quality development of strategic emerging industries, this paper reviews the research status at home and abroad on the mechanism and path, influence effect, support efficiency, support system, problems and countermeasures of financial support for the development of strategic emerging industries. At present, the research on financial support for the development of strategic emerging industries at home and abroad is mainly conducted from the perspective of financial support and financing. Under the two perspectives, the influence effect can be subdivided into direct financing, indirect financing and comprehensive financing, and the research on support efficiency can be divided into national and regional studies. The support system can be divided into three aspects: horizontal, vertical, and horizontal and vertical synthesis. Problems and countermeasures are subdivided into four aspects: countermeasures, policies, strategies and optimization paths. Future research directions include: Deepening the mechanism of financial support for strategic emerging industries from the perspective of financing; Expand the research of vertical support system for the development of strategic emerging industries.
A Systematic Literature Review of the Empirical Research on the Promoting Mechanism of High-Level Financial Opening to Innovative Development of Manufacturing Industry
Authors: Wu Jia-qi , Zhang Mu
Published: April 2023

To further enrich the research on the promotion mechanism of high-level financial openness on the innovation of the manufacturing industry, this article summarizes the domestic and foreign research on the impact mechanism of financial openness. Currently, the domestic and foreign studies are mostly based on the characteristics of different financial industries, including the role of opening-up on enterprise innovation and its influence on the bank industry; the effect of foreign direct equity participation on enterprise innovation and its influence on the securities industry; the impact of the host country on the innovation of insured companies and its influence on the insurance industry. Future research directions may include deepening research on the transmission mechanism of high-level financial openness on manufacturing innovation and expanding research methods for the impact mechanism of high-level financial openness on manufacturing innovation development.
A urgência do letramento racial e do antirracismo na educação brasileira
Authors: Moraes Julia Oliveira
Published: April 2023

O artigo em questão busca demonstrar como o sistema educacional brasileiro tem trabalhado em contradição com suas funções sociais ao reproduzir o racismo dentro de suas instituições e as consequências desse problema para a sociedade brasileira. Para isso, observa-se a distância abissal entre a legislação e o cotidiano enfrentado pelos brasileiros, afirma-se a necessidade do letramento racial nas práticas pedagógicas e acadêmicas a partir da observação de como o racismo se manifesta nas relações intergeracionais no contexto escolar, assim como nas práticas pedagógicas universitárias racistas como, por exemplo. o epistemicídio. O trabalho evidencia a urgência e sugere, ainda, caminhos para as instituições educacionais passarem a adotar o antirracismo como princípio pedagógico e político central na estruturação de suas bases teóricas, práticas e de gestão.
Variability of Common Carotid Intima-media Thickness Measured using B-mode and M-mode Ultrasound Imaging
Authors: Alghamdi Rawan , Zabani Remaz , Alahmari Teaf , Alahmadi Adnan A S , Albngali Ahmad , Abdeen Rawan , Sultan Salahaden R
Published: April 2023

Background: Common carotid artery intima-media thickness (cIMT) has been associated with cardiovascular diseases, including stroke and coronary heart disease. There is a limited number of studies that specifically address the variability of ultrasound imaging modes in measuring cIMT. Therefore, this study aimed to assess the agreement-level and inter-observer reproducibility of cIMT measurements using B-mode and M-mode.

Materials and Methods: B-mode and M-mode ultrasound imaging were used in measuring cIMT of healthy subjects using linear-array transducer. Inter-imaging mode agreement and inter-observer reproducibility of B-mode and M-mode were assessed using Intraclass correlation coefficient (ICC). Differences in cIMT measurements between imaging modes and observers were determined using paired t-test

Results: There was significant difference between B-mode and M-mode in measuring cIMT (mean difference (MD), 0.03 mm, 95% CI 0.02 - 0.05, p<0.001).  Intra-imaging mode agreement was poor with ICC of 0.39. Inter-observer reproducibility of cIMT measured using B-mode and M-mode were good and moderate, respectively, (B-mode ICC of 0.76, 95% CI 0.64 - 0.84, p<0.01; M-mode ICC of 0.68, 95% CI 0.52 - 0.78, p<0.01). No significant difference between the two observers in measuring cIMT measured using B-mode or M-mode (B-mode p=0.3; M-mode p=0.4). 

Conclusion: There was a significant difference and poor intra-imaging mode agreement between B-mode and M-mode in measuring cIMT. B-mode showed higher inter-observer reproducibility of cIMT measurement than M-mode. Further studies investigating the variability and agreement between ultrasound imaging modes of patients with thickened cIMT are required.
Musicians’ motor regions are deeper and thicker!
Authors: Alghamdi Jamaan
Published: April 2023

The human brain has an exceptional capacity to reorganize neural pathways and alter cortical patterns in response to environmental context. Early intensive musical training has a significant impact on brain development. Beginning at a young age, musicians integrate multiple functions (e.g., auditory, motor, visual, and cognitive tasks) comprehensively during musical performance, requiring the activation of multiple brain regions. In this study, I investigated the effect of musicianship on cortical thickness and sulcal depth in 15 musicians and 15 age-matched non-musicians. Image analysis was conducted using surface-based morphometry (SBM). The results indicate that musicians have increased cortical volume in multiple brain regions, including the motor and visual regions. These regions are part of the visual-motor coupling network, indicating that long-term practice may lead to GM adaptation in visual-motor related regions, thereby enhancing spatial attention and senso-motor transformation.
Tortoise beetles (Coleoptera: Chrysomelidae: Cassidinae) of West Bengal, India
Authors:   Zoological Survey of India, Prani Vigyan Bhawan, Block M, New Alipore, Kolkata, 700053, West Bengal, India, Ghosh Priyanka , Das Priyanka ,   Zoological Survey of India, Prani Vigyan Bhawan, Block M, New Alipore, Kolkata, 700053, West Bengal, India, Gupta Devanshu ,   Zoological Survey of India, Prani Vigyan Bhawan, Block M, New Alipore, Kolkata, 700053, West Bengal, India, C Raghunathan ,   Zoological Survey of India, Prani Vigyan Bhawan, Block M, New Alipore, Kolkata, 700053, West Bengal, India
Published: April 2023

Altogether, 52 species of tortoise beetles belonging to 11 genera and 4 tribes (Coleoptera: Chrysomelidae: Cassidinae) are reported from West Bengal, India in the present communication. The genus Cassida Linnaeus includes the maximum number of 21 species followed by Aspidimorpha Hope (11), Basiprionota Chevrolat (5), Laccoptera Boheman (4), Notosacantha Chevrolat (3), Chiridopsis Spaeth (3), Oocassida Weise (1), Epistictina Hincks (1), Glyphocassis Spaeth (1) and Conchyloctenia Spaeth (1) and Craspedonta Chevrolat (1).
ALMOST 1-TRANSITIVITY IN LINEARLY ORDERED STRUCTURES
Authors: Kulpeshov B. Sh. , Sudoplatov S. V.
Published: April 2023

The present paper concerns the notion of weak o-minimality introduced by M. Dickmann and originally deeply studied by D. Macpherson, D. Marker, and C. Steinhorn. Weak o-minimality is a generalization of the notion of o-minimality introduced by A. Pillay and C. Steinhorn in series of joint papers. As is known, the ordered field of real numbers is an example of an o-minimal structure. We continue studying model-theoretic properties of o-minimal and weakly o-minimal structures. In particular, we introduce the notion of almost 1-transitivity in linearly ordered structures and study tits properties. Almost 1-transitive o-minimal and weakly o-minimal linear orderings have been described. It has been established that an almost 1-transitive weakly o-minimal linear ordering is isomorphic to a finite number of concatenations of almost 1-transitive o-minimal linear orderings. Properties of expansions of families of almost 1-transitive linearly ordered theories are studied. Rank values for families of almost 1-transitive o-minimal and weakly o-minimal linear orderings have been found. A criterion for preserving both the almost 1-transitivity and weak o-minimality has been found at expanding an almost 1-transitive weak o-minimal theory by an arbitrary unary predicate. Dense ordering of an almost 1-transitive weakly o-minimal theory that is almost omega-categorical has been established.
Participatiebevordering: werken aan draagvlak voor de sociale zekerheid
Authors: Schippers Joop J. , Dykstra Pearl A. , Fokkema Tineke , Münderlein Maria
Published: April 2023

Improving the financial basis for social security arrangements

The key question of this study is whether policies adopted elsewhere in Europe might be useful in helping to increase the labour force participation of women and of older workers in the Netherlands, and thus improve the financial basis for social security arrangements. We examined the effectiveness of national policy measures over and above that of the individual-level determinants that are traditionally examined in economic and sociological studies. The data on labour force participation are from the European Social Survey, and information on public policy arrangements comes from the MULTILINKS database. Regarding the labour force participation of women, findings show the importance of distinguishing financial measures and care services. Women generally work fewer hours per week in countries with generous financial support for families (tax benefits, child support), and more hours in countries with generous parental leaves. Regarding the participation of older workers, findings show the importance of distinguishing the minimum pension level (negative association with the likelihood of having a job) and pension as a proportion of earned wage (no association with having a job). A novelty of the present study is its ability to demonstrate the impact of national arrangements at the level of individual participation behaviour.
Sociale zekerheid in 2025
Authors: de Kam Flip
Published: April 2023

Social Security in 2025

The reform of the Dutch welfare state is an ongoing process, that jumpstarted in the early 1980s. We chart demographic trends and prospects for economic growth up to year 2025. Our search for options to strenghten the economic base of the welfare state leads on to a discussion of tax-benefit measures to increase labour participation and to incentivise part-timeworkers to accept fulltime jobs. We conclude that, all in all, by 2025 the number of workers in de Dutch economy will not differ significantly from the current size of the labour force, whereas the scope to improve labour productivity seems to be limited. Given these limits to the prospects for future economic growth – even with the standard pension age at 67 years, planned to be in force as from 2021 –, our economy will have to support at least half a million more pensioners and an as yet unknown additional number of elderly unemployed and disabled. It follows, that further reforms of the social security system of the Netherlands can be expected, as public sector outlays claim currently already half of national output.
Biological Management of Root Knot Nematode, Meloidogyne incognita through Bacterial Antagonists Infecting Tomato
Authors: Anwar ul Haq Muhammad , Shahid Muhammad , Zeeshan Niaz Muhammad , Mahmood Kamra , Talal Muhammad , Adil Zuhaa , Manzoor Ahmad Hira
Published: April 2023

Root-knot nematodes have wide host range, causing damage to many annual and perennial crops. More than 100 species of Meloidogyne are known in which Meloidogyne incognita (Kofoid and White) Chitwood is one of the most common and important plant parasitic nematode in tropical and subtropical regions of the world including Pakistan. This study was planned to investigate the interaction of Plant Growth Promoting Rhizobacteria and Pasteuria penetrans for the management of root knot nematode M. incognita on tomato in green house at 30 + 4 0C. Earthen pots 20 cm dia. having sterilized soil was mixed with Pasteuria penetrans root powder @ 103 spores per gm of soil. Three week old seedlings of tomato Money Maker were transplanted singly in pots. One week after transplanting, 30 ml of bacterial (Bacillus subtilis, Pseudomonas fluorescens and Enterobacter cloacae) suspension were applied in root zone. Seven days after application of PGPR, 2000 J2 were applied at root zone. The experiment was arranged in Completely Randomized Design and six treatments were replicated tenfold. Pasteuria penetrans alone or in different combinations with PGPR were applied.  Pots with nematode and without PGPR, Pp and nematode were kept as control. Sixty days after nematode application, plants were harvested carefully. Data were recorded on plant growth parameters and nematode reproduction in terms of number of egg mass, number of females, number of galls and galling index (0-10). The plant treated with Enterobacter cloacae + Pp significantly suppressed the number of egg mass 69.38%, number of galls 68%, number of females 66.21% and galling index 56.82% compared to control resulting in improved growth over control. The treatments   B. subtilis + Pp and P.  fluorescens + Pp showed intermediary effect on both nematode reproduction and plant growth..Pasteuria penetrans was least observed effective in suppressing number of egg mass 57.53 %, number of females 55%, number of galls 55.73% and galling index 47.73%.
Admissibility of the former owner's claim for remuneration for the non-contractual use of the property for the period preceding its usucaption
Authors: Kledyńska Anna
Published: April 2023

The paper deals with the issue of admissibility of the former owner's claim for remuneration for the non-contractual use of real estate from the former owner of the real estate, who then became its owner as a result of usucaption. This issue has been a source of controversy for a long time, resulting in a divergence of views between the doctrine and the judiciary. Recently, this problem has revived in connection with the cassation complaint in case III CZP 103/22, in which a legal issue was submitted for resolution to a panel of 7 judges of the Supreme Court. The paper analyzes the arguments of supporters and opponents of the admissibility of the owner's claim for remuneration for the period preceding usucaption.
Compulsory mortgage as a form of security for tax liability
Authors: Dalkowska Anna
Published: April 2023

The principle of tax fairness contained in Article 84 of the Constitution of the Republic of Poland commands the organs of the public authorities to shape tax mechanisms in keeping with the principle of equality and universality. Ensuring the effectiveness of tax revenue, as a fundamental duty of the legislature, determines the necessity of creating institutional guarantees that ensure the organs of the executive authority not only with supervision over taxpayers fulfilment of their fiscal obligations, but also the securing of the said obligations in the future via jurisdictional proceedings, claim-securing proceedings, as well as at the stage of applying coercive measures in administrative enforcement proceedings. It also leads to interference in regard to individual rights under constitutional protection, which determines the necessity to create institutional mechanisms for protecting taxpayers and monitoring the activities of public authorities, including in particular judicial-administrative supervision. This paper analyses the institution of tax mortgage, as one of the forms of security for the performance of tax obligations. As a limited right in rem, tax mortgage constitutes an effective means of securing the performance of tax liabilities, not only at the stage of tax inspection, but also in the course of administrative enforcement and claim-securing proceedings.
Microplastic removal via physical and chemical methods
Authors: Feo L. , Pullar R. , Zaoui A.
Published: April 2023

A growing number of synthetic plastics derived from fossil fuels are produced, and improper plastic waste management has caused a lot of pollution problems. There are many microplastics in the environment, and they disintegrate slowly in soil and water. The properties of microplastics include long residence times, high stability, high fragmentation potential, and the ability to adsorb other contaminants. Invertebrates and planktonic organisms are easily able to accumulate microplastics in aquatic species. Therefore, microplastics (MPs) must be removed from the water and other media. This paper aims to review the occurrence, raw polymers and additives, and remediation methods for removing microplastics from the environment. Several methods are available for removing contaminants, including sorption, filtration, and chemical treatments. Various removal methods are discussed along with their methods, efficiency, and advantages.
EVALUATION OF THE STABILITY OF SARS-CoV-2 ANTIGEN IN CLINICAL SAMPLE AFTER MULTIPLE FREZEE-THAW CYCLES
Authors: Vu Huong , Pham Thuy , Pham Minh
Published: April 2023

Bộ mẫu chuẩn cho đánh giá hiệu quả chẩn đoán (độ nhạy, độ đặc hiệu…) là một tập hợp các mẫu có chứa tải lượng vi rút SARS-CoV-2 khác nhau. Một số nghiên cứu cho thấy nồng độ kháng nguyên trong mẫu lâm sàng dương tính với SARS-CoV-2 sau thời gian dài bảo quản ở nhiệt độ âm sâu có xu hướng thiếu ổn định[1].  Chúng tôi sử dụng 10 mẫu bệnh phẩm dương tính với SARS-CoV-2 để đánh giá ảnh hưởng của các chu kỳ tan băng tới sự phát hiện SARS-CoV-2 bằng test nhanh kháng nguyên trên mẫu dịch tỵ hầu trong môi trường vận chuyển vi rút (Virus tranmisssion medium- VTM). Kết quả nghiên cứu cho thấy kháng nguyên vỏ nhân (nucleocapsid- N) của vi rút trong mẫu nghiên cứu vẫn có thể phát hiện được sau 5 lần tan đông (không có sự khác biệt thống kê với p > 0,05). Nghiên cứu đã chứng minh được các mẫu bệnh phẩm bảo quản lạnh có thể sử dụng cho đánh giá chất lượng các sinh phẩm chẩn đoán nhanh theo nguyên lý phát hiện kháng nguyên SARS-CoV-2 sau 5 lần tan đông.
VALIDATION OF POTENCY TEST OF MEASLES COMPONENT IN VACCINE MMRII BY CCID50 METHOD
Authors: Nguyen Viet Anh , Do Anh , Nguyen Ha , Tran Phuong , Nguyen Ly
Published: April 2023

Sởi là một trong những bệnh truyền nhiễm qua đường hô hấp do vi rút gây ra có thể phòng ngừa bằng cách tiêm vắc xin. Việc đánh giá hiệu quả của vắc xin trước khi đưa ra thị trường là một nhiệm vụ quan trọng của Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm y tế (NICVB). Vì vậy, nhóm nghiên cứu tiến hành thẩm định quy trình thử nghiệm công hiệu thành phần sởi trong vắc xin  MMRII (MSD) với các tiêu chí độ đúng, độ chính xác, độ mạnh và độ đặc hiệu. Phương pháp thực hiện trong đề tài này được thực hiện theo SOP KĐQG- 34: Quy trình chuẩn thẩm định thử nghiệm toàn phần của Viện. Kết quả cho thấy, quy trình thử nghiệm công hiệu thành phần sởi trong vắc xin MMRII bằng phương pháp CCID50 đạt yêu cầu về các tiêu chí độ đúng, độ chính xác, độ mạnh và độ đặc hiệu qua từng lần thực hiện. Hiệu giá vắc xin mẫu chuẩn và mẫu thử đều nằm trong giới hạn cho phép với hệ số biến thiên CV ≤ 25%. Vì vậy, quy trình thử nghiệm công hiệu thành phần sởi trong vắc xin MMRII bằng phương pháp CCID50 cho kết quả tin cậy, phù hợp với điều kiện hóa chất và trang thiết bị của khoa Kiểm định vắc xin Vi rút và có thể áp dụng cho thử nghiệm thường quy tại Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm y tế (NICVB).
THE RELATIONSHIP BETWEEN HYPERCOAGULABILITY IN PATIENTS WITH HEREDITARY ACUTE PANCREATITIS DUE TO MUTATIONS IN THE PRSSI GENE ON THE BACKGROUND OF CUSHING'S SYNDROME
Authors: Dang Ha , Vu Yen , Luong Minh , Nguyen Trang
Published: April 2023

Báo cáo ca lâm sàng hiếm gặp một bệnh nhi bị viêm tụy di truyền liên quan đến gen PRSS1 trên nền hội chứng Cushing có tình trạng tăng đông nặng nề, được điều trị thành công bằng chế độ dinh dưỡng viêm tụy cấp, ostreotide, kháng sinh và chống đông Lovenox. Tìm hiểu mối quan hệ nhân quả của tình trạng tăng đông giữa bệnh viêm tụy và hội chứng Cushing.
Phân tích mô tả ca bệnh nhi nữ, 5 tuổi, tiền sử chẩn đoán hội chứng Cushing do thuốc từ 2 tuổi. Đợt này, trẻ diễn biến bệnh cấp tính với triệu chứng đau bụng từng cơn kéo dài và nôn nhiều.  Kết hợp xét nghiệm có men tụy tăng cao, chụp CT ổ bụng có hình ảnh viêm tụy cấp (CTSI=6 điểm). Trẻ được điều trị tại khoa Tiêu hóa, bệnh viện Nhi Trung ương với chẩn đoán Viêm tụy cấp mức độ nặng/ Hội chứng Cushing. Quá trình điều trị, trẻ xuất hiện tình trạng tăng đông trên xét nghiệm, chỉ số D-Dimer tăng cao từ ngày thứ 3 của bệnh; Fibrinogen tăng trên 5 g/l vào ngày thứ 7 của bệnh và lâm sàng. Tuy nhiên, tình trạng tăng đông kéo dài, tiếp tục hình thành huyết khối ở tĩnh mạch nông cánh tay phải vào ngày thứ 15 của bệnh trong khi tình trạng viêm tụy đã cải thiện. Các xét nghiệm đông máu cho thấy yếu tố von Willerbrand tăng cao (233,8%). Tình trạng tăng đông với tăng yếu tố vWF có thể liên quan đến hội chứng Cushing bệnh nhân mắc kèm. Vì muốn tìm hiểu mối liên quan của tình trạng đông máu của bệnh nhân có viêm tụy cấp trên nền hội chứng Cushing, bệnh nhân đã được làm phân tích gen và tìm ra đột biến gen PRSS1, liên quan đến viêm tụy di truyền. Trẻ đã được điều trị nhịn ăn, truyền dịch nuôi dưỡng, kháng sinh, chống đông Lovenox.  Bệnh nhân đã ổn định và ra viện sau 33 ngày điều trị.
Từ kết quả nghiên cứu trên cho thấy tình trạng tăng đông có thể xảy ra trong pha sớm của viêm tụy cấp nặng. Tuy nhiên, hội chứng Cushing cũng có thể gây tình trạng tăng đông với tăng yếu tố vWF. Điều trị viêm tụy cấp nặng cùng với điều trị thuốc chống đông Lovenox giúp bệnh nhân cải thiện bệnh.
The Effect of Storytelling Technique in Improving Students Speaking Ability at SMAN 1 Sidamanik
Authors: Sitanggang Nikita , Siahaan Basar Lolo , Turnip Roni Ripaldi , Gultom Destri
Published: April 2023

This research seeks to determine how the narrative method affects the speaking ability of SMAN 1 SIDAMANIK second-graders. This pre-experimental investigation with a population of thirty students selected groups using random cluster sampling. Before and after therapy, a narrative technique was used to collect data. Before and after the test, students receive instruction. The average score on the pre-test was 48.68, while the average score on the post-test was 54.97. Between the pre-test and post-test, the data indicate an increase. The research shows that the t-test is preferable to the t-table (4,827 > 2,04). The significant difference between the post-test and the pre-test suggests that the narrative method affects students' speaking ability. This demonstrates how a narrative approach can help students develop their public speaking abilities. The speaking component received the highest overall score, followed by syntax and speech, which received the lowest score, according to this research. Therefore, instructional methods must emphasize these elements.
Perspectives of ESL Learners on the Integration of Technology in English Language Learning Process: An Evidence-Based Research
Authors: Lamo Padma , Dhuli Raju , Larsari Vahid Norouzi
Published: April 2023

Technology is a part and parcel of this information age; no sphere of learning is untouched by it. The field of ELT/EFL/ESL is no exception. The current paper is an attempt to understand how the use of technology has been received in the field of English as a second language and gather perspectives from the learners of the English language about the effect of technology in their learning. The paper explores various modes of e-learning and how the tools aid traditional ways of teaching and learning English as a second language. An attempt has been made to trace new trends in learning with the ever-evolving technology in the 21st century. This paper has reviewed a few significant researches to give a perspective on the efficacy of modern technologies in learning English for ESL students.
Quid Quo Pro. I doosie, You doosie. Which are the language style for kids on series kids?
Authors: Amriani Annisa , Faizal Abdul Azis
Published: April 2023

This study looks at the language style used in series for kids, on title The Boss Baby: Back in Business. To describe how much language style used and the function of language style. Used qualitative research to analysis the dialogue on the series, the researcher discovered language style Apheresis, Bombastic, Simploke, Exclamation, Alusio, and Clinch. And several functions of language style, such as convey mood, persuade the readers or listeners, and to enhance the impact of the ideas presented. As the result, this study concludes that every film or series have language style which are different from each other. However, kids can still enjoy these movies or series with adult supervision
Development and Factorial Validation of Meta-Cognitive Awareness Inventory in Physics (MAIP) for Senior Secondary School Students in Benue State, Nigeria
Authors: Ellah Barnabas Obiaje , Emaikwu Sunday Oche , Obinne Amalonye Dayalata Ethel , Adikwu Odihi
Published: April 2023

Purpose: The study developed and factorial validated of Meta-cognitive Awareness Inventory in Physics (MAIP) for senior secondary school students in Benue State, Nigeria. Three research questions and one null hypothesis guided the study. Methodology: The study adopted instrumentation design. The sample comprised 1382 SSII students that offered Physics as a school subject for 2020/2021 Academic Session. The Meta-cognitive Awareness Inventory in Physics (MAIP) was face validated by five experts. Construct validation was carried out on the instrument. Coefficient of internal consistency was obtained through Cronbach’s Alpha and found to be 0.78. The research questions were answered using factor analysis, coefficient of internal consistency, mean and standard deviations. The null hypothesis was tested using independent t-test at 0.05 level of significance. Findings: The findings revealed that MAIP has 52 factorially simple or pure items and 23 factorially complex items in terms of their factor loadings. The coefficient of internal consistency of MAIP was found to be 0.98. It was also found that there was statistically significant difference in the mean meta-cognitive awareness ratings of students in rural and urban areas in favour of students in urban area using MAIP. Signifinance: It was recommended among others that Senior Secondary students should use the MAIP to determine their level of meta-cognitive awareness in Physics in both urban and rural schools. This may enable them to gain awareness and control over themselves as learners for effective learning of Physics in secondary schools irrespective of their locations.
Pengembangan Perangkat Pembelajaran Berbasis Problem Based Learning (PBL) pada Materi Matriks untuk Meningkatkan Kemampuan Representasi Matematis Siswa Kelas XI IPA SMAN 1 Bukit Batu
Authors: Sundari Ririn Dwi , Angraini Lilis Marina , Herlina Sari , Zetriuslita
Published: April 2023

Penelitian ini bertujuan untuk menghasilkan suatu perangkat pembelajaran matematika berupa Rencana Pelaksanaan Pembelajaran (RPP) dan Lembar Kerja Peserta Didik (LKPD) dengan menggunakan model Problem Based Learning (PBL) untuk Meningkatkan Kemampuan Representasi Matematis Siswa pada Materi Matriks Kelas XI IPA SMA yang valid, praktis dan efektif. Model pengembangan yang digunakan adalah ADDIE. Instrumen pengumpulan data yang digunakan adalah lembar validasi RPP dan LKPD, lembar angket guru dan lembar angket peserta didik, lembar soal pretest dan posttest. Teknik pengumpulan data yang digunakan yaitu; validasi dari 2 dosen dan 1 guru matematika, angket respon guru dan siswa dan hasil pretest dan posttest. Teknik analisis data yang digunakan adalah analisis data validasi, kepraktisan dan keefektifan. Dari hasil validasi RPP diperoleh rata-rata 100% dengan skala Guttman dikategorikan sangat valid dan 87,82% dengan skala Likert dikategorikan sangat valid. Hasil validasi LKPD diperoleh rata-rata 100% dengan skala Guttman dikategorikan sangat valid dan 85,06% dengan skala Likert dikategorikan sangat valid. Hasil angket respon guru diperoleh rata-rata 96,25% dikategorikan sangat praktis. Hasil angket respon peserta didik diperoleh rata-rata 87,10% dikategorikan sangat praktis. Hasil rata-rata N-gain score sebesar 91% dengan kriteria tinggi dan dikategorikan efektif. Berdasarkan penelitian ini diperoleh Rencana Pelaksanaan Pembelajaran (RPP) dan Lembar Kerja Peserta Didik (LKPD) dengan Model Problem Based Learning (PBL) untuk Meningkatkan Kemampuan Representasi Matematis Siswa pada Materi Matriks Kelas XI IPA SMAN 1 Bukit Batu yang valid, praktis dan efektif. Sehingga perangkat pembelajaran layak untuk digunakan.

Kata Kunci: Rencana Pelaksanaan Pembelajaran (RPP), Lembar Kerja Peserta Didik,   Problem Based Learning (PBL)
Efektivitas Model Means Ends Analysis (MEA) Terhadap Kemampuan Pemecahan Masalah Matematis Siswa SMP
Authors: Permana Siti Gita
Published: April 2023

Kemampuan pemecahan masalah matematis adalah kemampuan menyelesaikan masalah dengan menggunakan aturan-aturan yang telah dipelajari. Penelitian ini bertujuan untuk mengidentifikasi peningkatan dan pengaruh penerapan model means ends analysis (MEA) dalam pembelajaran matematika terhadap kemampuan pemecahan masalah matematis siswa. Penelitian ini dilakukan di salah satu SMP Negeri di Karawang, Jawa Barat. Metode penelitian yang digunakan adalah metode quasi eksperimen dengan desain Nonrandomized Control Group Pretest–Posttest Design. Sampel penelitian ini adalah 80 siswa yang terdiri dari 40 siswa untuk kelas eksperimen (VII-F) dan 40 siswa untuk kelas kontrol (VII-D). Penentuan sampel dilakukan dengan menggunakan teknik purposive sampling pada kelas VII. Pengumpulan data setelah perlakuan dilakukan dengan menggunakan instrumen tes pemecahan masalah matematis. Hasil penelitian mengungkapkan bahwa rata–rata kemampuan pemecahan masalah matematis siswa yang diajarkan dengan model means ends analysis lebih tinggi dari pada siswa yang diajarkan dengan pembelajaran langsung. Selain itu model means ends analysis (MEA) memiliki pengaruh terhadap kemampuan pemecahan masalah matematis dengan efek yang besar. Kesimpulan hasil penelitian ini adalah bahwa model means ends analysis efektif dalam meningkatkan kemampuan pemecahan masalah matematis siswa.
The association between child maltreatment and mental disorders in the Australian Child Maltreatment Study
Authors: Scott James G , Malacova Eva , Mathews Ben , Haslam Divna M , Pacella Rosana , Higgins Daryl J , Meinck Franziska , Dunne Michael P , Finkelhor David , Erskine Holly E , Lawrence David M , Thomas Hannah J
Published: April 2023

Objectives

To examine the associations between experiences of child maltreatment and mental disorders in the Australian population.

Design

Population‐representative survey conducted by computer‐assisted telephone interviewing.

Setting, participants

Australian residents aged 16 years and older.

Main outcome measures

Mental disorder diagnoses of lifetime major depressive disorder, current alcohol use disorder (mild, moderate and severe), current generalised anxiety disorder and current post‐traumatic stress disorder.

Results

More than one in three Australians (3606/8503 surveyed participants; 38.0%; 95% CI, 36.7–39.3%) met the diagnostic criteria for a mental disorder. The prevalence of mental disorders in non‐maltreated participants was 21.6% (95% CI, 19.9–23.3%; n = 851). This increased to 36.2% (95% CI, 33.5–38.9%; n = 764) for those who experienced a single type of maltreatment and 54.8% (95% CI, 52.6–56.9%; n = 1991) for participants who experienced multi‐type maltreatment. Compared with non‐maltreated Australians, maltreated participants had about three times the odds of any mental disorder (odds ratio [OR], 2.82; 95% CI, 2.47–3.22), generalised anxiety disorder (OR, 3.14; 95% CI, 2.48–3.97), major depressive disorder (OR, 3.19; 95% CI, 2.68–3.80) and severe alcohol use disorder (OR, 2.62; 95% CI, 1.83–3.76), and almost five times the odds of post‐traumatic stress disorder (OR, 4.60; 95% CI, 3.00–7.07). Associations between experiences of child maltreatment and mental disorders were strongest for sexual abuse, emotional abuse and multi‐type maltreatment. The strength of the associations did not differ by gender. Adjustment for childhood and current financial hardship and for current socio‐economic status did not significantly attenuate the associations.

Conclusions

Mental disorders are significantly more likely to occur in individuals who experience child maltreatment, particularly multi‐type maltreatment. Prevention of child maltreatment provides an opportunity to substantially reduce the prevalence of mental illness and improve the health of the Australian population.
التلقيح الصناعي في ضوء الفقه الإمامي
Authors: حسن عبد الأمير عبد الرضا
Published: April 2023

تعدّ المسائل المستحدثة من الأمور المهمة التي تمسّ حياة المسلم وضرورة إيجاد حلول واقعية لها على ضوء الأدلة الشرعية، فلم يدّخر فقهاء الشريعة بكافة مذاهبهم جهدا في بيان موقف الإسلام منها، ومن تلك المسائل عملية التلقيح الصناعي، ولم أستعرض آراء باقي المذاهب الإسلامية، لكثرة ما كُتب في هذا المجال، وخصصتُ البحث لاستعراض آراء بعض علماء الإمامية في هذه المسألة على ضوء الموازين الشرعية للإسلام، أهمية البحث تكمن في قلة ما كتب حول موضوعة التلقيح في كتب الإمامية على ضوء مناهج البحث الأكاديمي رغم وجود كتابات لفقهاء كبار في هذا المجال. والشائع بين هؤلاء الفقهاء الأعلام القول بحرمة تلقيح المرأة بمني الرجل الأجنبي وجواز تلقيحها بمني زوجها.

هدف هذا البحث لبيان الموقف الفقهي تجاه مسألة التلقيح الصناعي بناء على رأي فقهاء الإمامية الاثني عشرية، إذ يكثر السؤال حول هذه المسألة الابتلائية. واستخدم الباحث المنهج اعتمدت المنهج التكاملي المؤلف من المنهج النقلي في بعض المسائل والمنهج العقلي في بعض المسائل الأخرى، كما هو الشائع في الدراسات الإسلامية العليا.
الجنس المقدس وشغف العبور من الدنيوي إلى الحلول في السرمدية
Authors: عكية جوهرة القدس
Published: April 2023

هدفت الدراسة الإحاطة بموضوع الجنس المقدس من خلال التصدي لجملة من القضايا والإشكالات التي بدت في نظرنا ضرورية وحاسمة في ذات الآن، كما هدفت إلى رصد التطورات التاريخية للأنكحة والممارسات الجنسية منذ مرحلة ما قبل الإسلام، معززين ذلك بحالات ونصوص من الثقافة العربية الإسلامية، ومتون بعض الأساطير، وما تتضمنه هاته النصوص من تصور حول الممارسة الجنسية. واعتمدنا في هذه الدراسة على مناهج مختلفة، وتبنت مقاربة تحليلية. وتوصلت الدراسة إلى مجموعة من التوصيات أهمها أن الديانات السماوية أولت اهتماما بالغا للجنس، وأحاطته بهالة من القداسة عبر التاريخ. وجعلت منه طقسا يصل الإنسان الفاني بالكون اللامتناهي، وعبادة تتيح للفرد على المستوى الدنيوي تكرار ما قامت به القدرة الإلهية على المستوى المتعالي/المطلق.
البنى الاستعمالية المتعددة في الجر وتأثيرها في دلالة السياق
Authors: أحمد إيمان عبد اللّه محمد
Published: April 2023

يتعرض البحث إلى قضية البنى الاستعمالية المتعددة في الجر وتأثيرها في دلالة السياق، ويبدأ بتمهيد في معنى البنى الاستعمالية في الجر وأنواع هذه البنى الجرية، ويبدأ ببنى الإضافة الاستعمالية، وتأثير هذه البنى في دلالة السياق، ثم يعرج على بنى الجر الاستعمالية، وهي المتعلقة بحروف الجر وتأثيراتها في دلالة السياق، وذلك بتفصيل الجر بحروف الجر الأصلية العشرون عند النحاة، ثم الجر بحروف الجر الزائدة وهي الكاف والباء ومِن، وأن غالبية استعمالها للتأكيد، ثم الجر بحروف الجر الشبيهة بالزائدة، ثم الجر بالتبعية وهي التوابع الأربعة الوصف والبدل والعطف والتأكيد وأثر التنوع التركيبي في ذلك على المعنى والسياق.

استخدمت الباحثة المنهج الاستقرائي التحليلي من خلال استقراء بعض المواضع التي تعتبر نماذج للتنوع البنيوي بأنواعه. وتوصلت الباحثة إلى عدد من النتائج أهمها: أن أفخم استعمالات الجر هو في الإضافة بأنواعها ودلالاتها المتباينة في سياقاتها، وأن الجر بالحرف متسع المجال والدلالة والاستعمال، وأنه من أكثر الدلالات المختلفة في الكلام. كما أوصت الدراسة بمجموعة من التوصيات أهمها: التعمق في دراسة أساليب الجر واستعمالاتها؛ لأنها لم تلق اهتمام المنصوبات والمرفوعات ، الجرأة على دراسة المسائل التي فيها رأي جديد في أساليب التعبير ودلالتها السياقية.
اغتيال السيد محمد محمد صادق الصدر وردود الفعل في الصحف العربية المعاصرة عام 1999م
Authors: الزهيري رائد وليد طالب
Published: April 2023

تعد حادثة الاغتيال من المواضيع المهمة التي كان لها الاثر الكبير على المستوى السياسي والديني والاجتماعي سواء كان ذلك الاثر داخلياً في العراق أو خارجياً, ففي العراق حدثت اضطرابات حتى وصفت بأنها بداية النهاية للنظام الحاكم في العراق, فضلاً عن فقدان عالم جليل له أثره على الساحة الشيعية, وله اتباع وموالين, وله اثر على الحياة الاجتماعية, وبما أن الصحف تمثل لسان حال الزمان الذي نطقت به, ولنكن أكثر حيادية في نقل الحقائق حول من يقف وراء حادثة الاغتيال جاء عنوان الدراسة "اغتيال السيد محمد محمد صادق الصدر وردود الفعل في الصحف العربية المعاصرة عام 1999" ليسلط الضوء على حقبة زمنية مهمة من تاريخ العراق المعاصر.
التفكير الإيجابي وعلاقته بالثقة بالنفس لدى طالبات المرحلة الثانوية في غزة
Authors: سكيك رندة جمال
Published: April 2023

يهدف البحث إلى معرفة العلاقة بين التفكير بطريقة إيجابية والثقة بالنفس عند الطالبات في المرحلة الثانوية في غزة، واتبع البحث المنهاج العلمي الوصفي الارتباطي، حيث تم اختيار عينة من الطالبات في الصف العاشر بمدرسة بلقيس اليمن الثانوية، بلغ عددها (97) من الطالبات، طبقت عليهم الأداة البحثية (المقياس المتعلق بالتفكير الإيجابي) من إعداد الباحثة  و(المقياس المتعلق ب الثقة بالنفس) من إعداد(نصار،2018)، و بعد أن تأكد صدق وثبات الأدوات استُخدِم برنامج (SPSS) لتحليل البيانات، بعد تطبيق اختبارات عدة منها (ت T-TEST) لعينتين مستقلتين و(ت) لعينتين مرتبطتين ومعامل مربع إيتا، والتباين الأحادي، وتوصلت الاستنتاجات إلى أنه توجَد علاقة ارتباطية طردية تربط الثقة بالنفس وتفكير الفرد بطريقة إيجابية، وأن وزن الدرجة الكلية النسبي للمقياس المتعلق بالتفكير الإيجابي قيمتها (60%) ، ووزن الدرجة الكلية النسبي للمقياس المتعلق بالثقة بالنفس كان قيمتها (69%) ، وقد أوصت الباحثة بتدريب الطلاب والمدرسين وأولياء الأمور على أنماط التفكير الإيجابي لما له الأثر الجيد على تنمية جميع جوانب الشخصية بشكل إيجابي وزيادة الثقة بالنفس.
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA PEMBELAJARAN IPA
Authors: Tanjung Rahman , Supandi  , Nurfalaahiyyah Rahmi
Published: April 2023

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar siswa dengan penerapan model pembelajaran problem based learning. Penelitian ini menggunakan metode penelitian tindakan kelas (PTK). Subjek penelitian pada penelitian tindakan kelas ini adalah seluruh siswa Kelas IV yang berjumlah 22 orang siswa terdiri dari 6 orang siswa laki-laki dan 16 orang siswa perempuan. Teknik pengumpulan data dalam penelitian ini menggunakan tes dan observasi. Adapun hasil dari penelitian ini yaitu dengan diterapkannya model pembelajaran problem based learning dapat meningkatkan hasil belajar siswa. Hal ini dilihat dari hasil belajar pra siklus ke siklus I, siklus II sampai ke Siklus III yakni dari ketuntasan klasikal hanya sebesar 27 % menjadi 73 % di siklus I dan meningkat lagi menjadi sebesar 86 % di siklus ke II dan meningkat lagi di siklus ke III menjadi 90% dengan rata – rata nilai pra siklus sebesar 48 setelah diterapkannya model problem based learning menjadi 71 di siklus I dan setelah dilaksanakannya tindak lanjut pada siklus II dan siklus ke tiga menjadi 90. Begitu pula dengan proses pembelajaran siswa juga mengalami peningkatan dari perolehan skor siklus I sebesar 28 (64 %) menjadi siklus II sebesar 41 (88 %) dan siklus ke III dengan total skor 44.
Spot size and detector unsharpness determination for numerical measurement uncertainty determination
Authors:   University of Erlangen-Nürnberg (FAU), Orgeldinger Christian ,   University of Erlangen-Nürnberg (FAU), Wohlgemuth Florian ,   University of Erlangen-Nürnberg (FAU), Müller Andreas Michael ,   University of Erlangen-Nürnberg (FAU), Hausotte Tino
Published: April 2023

As the experimental measurement uncertainty evaluation for computed tomography is currently an expensive and timeconsuming task, numerical uncertainty evaluation (according to GUM Supplement 1) using a virtual CT is a promising alternative. For this digital twin to simulate accurate measurement results, the virtual CT system needs to be modelled as reallistically as possible using adequate input parameters for the simulation. This paper describes a method for the separated determination of two significant input parameters: focal spot size and detector unsharpness. The method is tested using a wide range of measurement parameters on a Zeiss Metrotom 1500 with different test specimen. It could be shown that the method yields reasonable results for most parameters. In addition, there is a dependence of the focal spot size on the ratio of tube voltage and tube current at constant power. This contradicts the wide-spread rule of thumb that the spot size depends on the tube power only. Indications of a changing focal spot shape at high powers could be detected.