bluuebunny/crossref_metadata_2025 huggingface dataset:
Guided bone regeneration using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked type-I collagen membrane with biphasic calcium phosphate at rabbit calvarial defects
Authors: Park Jin-Young , Jung Im-Hee , Kim You-Kyoung , Lim Hyun-Chang , Lee Jung-Seok , Jung Ui-Won , Choi Seong-Ho
Published: June 2015

Background

In-vitro
and animal studies using EDC cross-linked membranes have shown great resistance to enzymatic digestion as well as low cytotoxicity, and indicated its potential expediency as a barrier membrane for guided bone regeneration (GBR). The purpose of this study was to evaluate the efficacy, biocompatibility and degradation kinetics of a novel 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked type I collagen membrane for regeneration of rabbit calvarial defects. EDC cross-linked type I collagen membrane and macroporous biphasic calcium phosphate (MBCP) consisting of 60 % hydroxyapatite and 40 % β-tricalcium phosphate were used in this study. Four circular defects (ø = 8 mm) were created in each calvarium of 12 male white rabbits. The experimental groups randomly allocated to the defects were as follows – (1) sham control, (2) EDC-cross-linked collagen membrane (EDC membrane), (3) bone graft (BG), and (4) bone graft with collagen membrane (B-EDC membrane). Specimens were harvested at 2 weeks (
n
 = 6) and 8 weeks (
n
 = 6) postoperatively for observational histology and histometrical analysis.

Result

The histologic observation showed close adaptation of the EDC membrane to the defect perimeters along with vascularization of the membrane at 2 weeks. Direct apposition of new bone on to the collagen matrix could be observed displaying adequate tissue integration. Collapsing of the central portion of the membrane could be seen in the EDC membrane group, and both BG and B-EDC membrane groups showed greater total augmented area and new bone area than the EDC membrane group. The membrane was largely unresorbed at 2 weeks; and at 8 weeks the overall shape of the membrane was still maintained suggesting sustained barrier function at 8 weeks.

Conclusion

Within the limits of this study, it may be concluded that EDC-cross-linked collagen membrane is a safe biomaterial with adequate tissue integration and resorption kinetics to support bone regeneration when used in conjunction with bone filler.
Novel fracture zone identifier attribute using geophysical and well log data for unconventional reservoirs
Authors: Maity Debotyam , Aminzadeh Fred
Published: June 2015

We have characterized a promising geothermal prospect using an integrated approach involving microseismic monitoring data, well logs, and 3D surface seismic data. We have used seismic as well as microseismic data along with well logs to better predict the reservoir properties to try and analyze the reservoir for improved mapping of natural and induced fractures. We used microseismic-derived velocity models for geomechanical modeling and combined these geomechanical attributes with seismic and log-derived attributes for improved fracture characterization of an unconventional reservoir. We have developed a workflow to integrate these data to generate rock property estimates and identification of fracture zones within the reservoir. Specifically, we introduce a new “meta-attribute” that we call the hybrid-fracture zone-identifier attribute (FZI). The FZI makes use of elastic properties derived from microseismic as well as log-derived properties within an artificial neural network framework. Temporal analysis of microseismic data can help us understand the changes in the elastic properties with reservoir development. We demonstrate the value of using passive seismic data as a fracture zone identification tool despite issues with data quality.
Comprehensive knowledge base of two- and three-dimensional activity cliffs for medicinal and computational chemistry
Authors: Hu Ye , Furtmann Norbert , Stumpfe Dagmar , Bajorath Jürgen
Published: June 2015

Activity cliffs are formed by pairs or groups of structurally similar or analogous active compounds with large differences in potency. They can be defined in two or three dimensions by comparing graph-based molecular representations or compound binding modes, respectively. Through systematic analysis of publicly available compound activity data and ligand-target X-ray structures we have in a series of studies determined all currently available two- and three-dimensional activity cliffs (2D- and 3D-cliffs, respectively). Furthermore, we have systematically searched for 2D extensions of 3D-cliffs. Herein, we specify different categories of activity cliffs we have explored and introduce an open access data deposition in ZENODO (doi: 10.5281/zenodo.18490) that makes the entire knowledge base of current activity cliffs freely available in an organized form.
Multimedia Technology in Teaching Professionally-Oriented Communication in a Foreign Language
Authors: Ращупкина  , Rashchupkina K.
Published: June 2015

The article deals with the use of multimedia technology in teaching professionally-

oriented communication in a foreign language in a higher educational

institution.The author thoroughly describes the advantages of

multimedia in studying process, touches upon the information and communication

technology within the framework of contemporary educational

paradigm, underlines the importance and topicality of use of multimedia

in language education. Such kinds of problem search tasks as hot list and

web-quest are considered within the competence approach. The author

gives different kinds of methods and technology of foreign (English) language

teaching in a higher educational institution with the help of multimedia,

offers internet-resourses for language education.
Learning to Communicate in Russian as a Foreign Language: the Principles, Methods, Techniques, Results
Authors: Буханцева  , Bukhantseva Yu.
Published: June 2015

The principle of learning is the basic category of any technique. In teaching

Russian as a foreign language is recommended to follow the principles, is a

system of components. The author in the article reflects the most effective

methods and techniques of training trials.

It is known that training is only effective when students exhibit cognitive

activity and interest. Therefore, taking into account the interests of learners,

allocated special teaching methods, while properly integrating them to better

learn the language.

Knowledge of systems identified in the research process of learning Russian

as a foreign language will simplify the process of language teaching

in the classroom, in accordance with its laws, to display the content of the

educational material, to choose the most appropriate forms and methods

of teaching, thereby gradually achieving efficiency of mastering RCTs. Foreigners

can freely acquire communication in Russian, Russian language

to understand and apply this knowledge in practice, if the right to build the

learning trials, taking into account the basic principles outlined in this article.
Representation of the Interpersonal Aspect “a Reviewer – a Reader” in the German Critical Text
Authors: Кремер  , Kremer Inessa
Published: June 2015

The paper is devoted to the representation of the interpersonal aspect “a reviewer – a reader” in the German critical text. Theoretical aspects of this issue are highlightened. In the course of analysis the position of activisation of readers’ attention and readers’ cooperation is studied. The main attention is paid to the means of expressing relationships “a reviewer – a reader”, where cognitive and linguopragmatic approaches to the interpretation of the text are used as the main criteria.
Manipulative Potential of Creolized Text
Authors: Вашунина  , Vashunina Irina
Published: June 2015

Possibilities of implementation of manipulative strategy using creolized texts

are considered in the article. Texts with the illustrations can be used as

implementation tactics of evasion from the topic means, also can be used

repetition, pulling out the words of the of context, crushing, fragmented filing

information, creating allusions, unification of images of the language consciousness,

imposing images, melioration, creating of positive evaluation,

pejorarus, of creating of negative evaluation.
Adaptation of the Communicative Teacher Student Model to Requirements of Modern Higher Education
Authors: Колесникова  , Kolesnikova Natalia
Published: June 2015

The article is about changes in higher school teacher’s communicative behavior. These changes are caused by developments in russian education under conditions of the market economy, principles of free enterprise and contract relations. The author reviews the influence of educational process subject transition on communication model: authoritarian behavior- >collegiate. In order to meet the requirements to a personal component of a behavioral pattern an up-to-date teacher needs knowledge of several additional subjects such as psychology, sociology, marketing and economy. In the article one can find practical measures that can help a teacher to fit in a new concept of education.
Functions of Test Technologies
Authors: Кузнецова  , Kuznetsova L.
Published: June 2015

The article discusses the experience of testing in high school practice of

teaching Russian language and culture of speech. Examines the feasibility

of using different forms of tests.
Analysis of legal acts on combating corruption in Ukraine
Authors: Новгородцев Виктор , Novgorodtsev Viktor
Published: June 2015

The article presents an analytical review of the new legislation adopted in Ukraine, which reflects the main directions of the reform in the field of legislation in the organs of public service and local government, as well as addresses the issues of financial accountability of political parties to ensure reviewing anti-corruption programs in the structure of state bodies, carrying out monitoring in the field of public procurement, amendments to the judicial system and the criminal justice agencies, ensuring free competition and the establishment of responsibility for bribery for persons working in private companies. According to the results of the analytical review it can be concluded that the country has adopted a number of innovations: created the National Agency, which is addressing issues in the field of prevention of corruption as a central executive body with special status; formed a list of specific restrictions on the use of official position in the preparation of gifts; limited capacity of public servants, the leading career concurrently; introduced regulated fundamental rules of ethical conduct for civil servants; strengthened financial control (paying special attention to providing the declaration of income); the legislator specified persons having authority to assist in the fight against corruption; conducted special checks of candidates applying to practice high-level government posts.

Based on the analysis of new laws adopted in Ukraine, the author marked obstacles to the effective fight against corruption in the country, the main ones are corruption in public procurement, the judiciary and criminal justice authorities in the activities of executive bodies in the private sector, as well as the virtual absence of responsibility for bribery of persons working in private companies, special forfeiture rules for all corruption-related crimes, guaranteeing the protection of corruption whistleblowers and the unified state register of legal persons involved in corruption.
Problems of the rights of participants of criminal proceedings in terms of measures of restraint
Authors: Новгородцев Виктор , Novgorodtsev Viktor
Published: June 2015

The article considers the relationship to ensure the rights and freedoms of participants in the proceedings and other persons in the process of application and the election of preventive measures involving deprivation of liberty. The decision on measures of restraint in the form of home arrest must be justified by specific factual circumstances. They may not be data untested in court, in particular the results of operational-investigative activity granted in violation of the requirements of Art. 89 of the Criminal Procedure Code. The legislator leaves the list of premises open to the court with the circumstances of the case where it shall be entitled to decide on the specific premises for the execution of home arrest at its discretion. The Court needs to check the base of residence of the suspect or the accused in a particular dwelling. That must be a house where the defendant resides, where his property and / or the family resides. Location of home arrest may be outside the municipality, in the territory of which the preliminary investigation on the condition that this would not preclude the implementation of the criminal proceedings, in particular bringing the person in the body of inquiry or preliminary investigation body and the court. The essence of home arrest as a preventive measure, a specific set of prohibitions and restrictions are analyzed. At the same time the court should take into account the identity of the suspect or the accused. Necessary additions are proposed to the law to regulate the process of preparing a preventive measure.
Legislation on administrative responsibility for violation of fire safety: Analysis of changes over the past decade
Authors: Татарян Владилен , Tataryan Vladilen , Татарян Елена , Tataryan Elena
Published: June 2015

This article analyzes the federal law on administrative responsibility for violation of fire safety requirements. The authors, in particular, studied and analyzed in detail the federal laws, which the legislator over the last decade that made very substantial changes and additions to the relevant articles of the Administrative Code (the Administrative Code), as well as considered the changes that have occurred with these norms, the regularities and the correlation between the legislative wording and the social, economic and political changes taking place in a specific historical period of development of the state.

The authors make proposals for the development of this legislation, to simplify its use for law enforcers, to clarify the meaning of legal wording.

The process of fundamental reform of federal legislation providing for responsibility for the violation of fire safety requirements, has not yet been completed, but because the current deputies of the sixth convocation of the State Duma of the Russian Federation together with the scientists and administrative officers of the Federal State supervising the fire safety laws have yet to resolve a number of contentious issues and conflicts, related to the proper application of the relevant administrative procedures.
Background crime conditions and their impact on violent sexual offending
Authors: Семерикова Алла , Semerikova Alla
Published: June 2015

The article deals with objective social determinants of sexual violence, special importance is given to the terms of this type of crime. The study was conducted by compiling the sample survey of victims of sexual violence, as well as those serving sentences for violent sex crimes or committed similar crimes in the past. Determined are the conditions of violent sexual crimes, according to the author, it is understood background criminogenic effects that are not related to the criminal activity of the individual manifestations, but nevertheless, at the present stage of development of society are considered immoral and undermining the ethical foundations of society as a whole. In this case, we can not say that they are the cause of violent sexual criminal assault, but play a significant role in the formation of the motivational sphere of life not only encroaching person, but their victims, significantly increasing the level of victimization and, consequently, facilitating the commission in relation to the crime. Among these phenomena are three main ones: alcohol abuse, prostitution and pornography. These background criminogenic phenomena - the formation of a powerful provocateur defects for socialization of the person under whose influence they had a distorted attitude and mentality. The article defines the concept of the norm of sexual behavior of the individual and can be traced to changes in the concept of the person under the influence of normal background criminogenic effects and inclusion of the individual in these extremely destructive processes. The problem of correlation of background criminogenic phenomena between the concept of norms of sexual behavior, as well as provides psychological and social characteristics of background criminogenic phenomena and to determine the degree of their influence on the behavior of the mechanism of victims of sexual violence and encroaching persons.
Free legal aid: theory and practice
Authors: Бугрова Валентина , Bugrova Valentina , Сабурова Лариса , Saburova Larisa
Published: June 2015

The degree of competence of the public about the system of free legal aid is unfortunately low. Most citizens do not know that free legal aid is, that it can be obtained in legal clinics and non-profit organizations, and that the service quality can be high. Moreover, people who are confronted with legal problems, even the most simple and everyday, often are coming up with the idea that it can be solved easily, efficiently, and most importantly free. To eliminate this serious problem in the area of ​​public awareness is needed to make substantial efforts. Prospects for the formation of non-governmental legal aid system is quite high. It´s a really neat institute in modern reality. Legal relations are complicated, people just need help. And pay for the services of expensive lawyers cannot be afforded by everyone. Accordingly, the so-called public order is in abundance. Another question is that the development of this system, in particular the example of legal clinics, needs strong support. This article focuses on the provision of free legal aid. The paper identified the main directions of work with those categories of persons who in accordance with the legislation of the Russian Federation may be granted legal aid. Analyzed are the main provisions of the Federal Law of 2011 № 324-FZ on free legal aid in the Russian Federation, which is the main regulatory instrument governing the system of legal aid, as well as the Federal Law of May 31, 2002 № 63-FZ "On Advocacy Activity and Advocacy in the Russian Federation", the provisions of which are also partially regulated by this institution.
Corporate responsibility of business as an innovative approach to solving social problems
Authors: Фехтел Елена , Fekhtel Elena
Published: June 2015

Currently, in the society of various countries there are transformational processes affecting the legal, political and social spheres. Innovative changes in the economy, politics and law lead to rapid modifications of many established social stereotypes, attitudes and structures. Questions of civil society and of individual spheres of life are essential components of the internal and foreign policy. Effective and innovative development of different countries depends on the quality of life and well-being of citizens. Reliability and stability of the rule of law is dependent on the legal competence and cross-sectoral cooperation between the parties. State and civil society in the framework of the democratic structure are interested in supporting each other. Corporate social responsibility is one of the leading themes in the contemporary debate about the methods and mechanisms for the sustainable development of society. As a new field of knowledge, it generates new concepts in the context of transformation of society. At the present stage of development of civil society the socially responsible type of business conduct is an activity of the commercial sector in their political and legal forms, corresponding to the interests of society. Cost-effectiveness encourages socially responsible business to actively seek ways and forms of interaction between government, business and social interest groups. New mechanisms of mutual relations in the future will become the leading basis to improve the management of social processes in order to manage the risks of undermining the stability and predictability of the prospective development of the democratic state. The article substantiates the conclusion that only the ability to combine the interests of different groups and stakeholders to transform cultural heritage, value opinion in their own strategic objectives and processes for effective decision-making in various spheres of social life of the community will be able to survive in the conditions of globalization.
The role of the Constitution of the Russian Federation in crime prevention measures
Authors: Семерикова Алла , Semerikova Alla
Published: June 2015

The article deals with the problem of crime prevention in the Russian Federation at the present stage. The article analyzes the role of the constitution in the mechanism of prevention of crime, through empirical analysis of the determinants of criminal behavior as a whole, which is based on a sample survey on the topic "What are the legal action, in your opinion, crucial in the process of crime prevention?" The study surveyed two groups of respondents : the first group is consisted of experts and criminologists, law enforcement officials, the second - the average people in the street without a legal education and specialized knowledge in combating and prevention of crimes.

This article deals with the concept of the constitutional crime and crimes against constitutional rights and freedoms. The main instrument of crime prevention can be regarded as the constitutional authorities of social services aimed at providing social and legal services, to carry out social rehabilitation of people who need help; institutions involved in legal education, explaining the essence of the fundamentally inalienable rights and freedoms; as well as political parties, movements, foundations, religious organizations, representatives of which are engaged in educational and preventive work with citizens. The reasons of the inefficiency of measures aimed at preventing the constitutional crimes are identified, including defining the role for the dominant ideology of wealth, imposed on us from outside. The system of measures is suggested for the most effective prevention of crime and minimization of constitutional possible negative consequences of committing crimes against constitutional rights and freedoms. The article substantiates the position that a person, its rights and freedoms are the supreme value in the state.
Sources of law of the British colony Quebec in the last third of the XVIII century: the problem of choice
Authors: Котов Сергей , Kokotov Sergey
Published: June 2015

A distinctive feature of modern Canada is the dualism of its legal system. This means that in the country there are two systems of law - continental (Roman-German) and Anglo-Saxon (precedent). Each of these systems differ in their approaches to the understanding of law and justice implementation. However, the main difference is due to the fact that each of these systems relies on its own sources of law. If the basis of the criminal and private law in general, and the federation of nine provinces in particular is common (case) law of England, in the province of Quebec are used English (basically) criminal law and French civil law in its origin.

Historically, this was due to the fact that at the time of the conquest of the colony of New France (now Quebec) in the XVIII century it had a relatively developed legal system, including the system of administration of justice. At the heart of the local sources of law were kutyums of Paris, supplementing ordinances of the French kings. Inclusion of New France in the possession of the English Crown was for the new authorities a precedent - the first time in the history of the British colonial empire it acquired a part of the territory with a Christian population and European law.

In fact, the British colonial authorities had to make a choice, which was to determine the vector of further legal development of not only the newly conquered colony, but the whole of British North America. According to the rules of English case law the medieval English monarch (as sovereign) could either admit the law to of its new ownershipin force at the time of the conquest, or introduce there English law in force at the time. In view of the prevailing circumstances of the specific historical issue of the replacement of French law (including sources and the administration of justice) in English it turned out to be extremely difficult from the socio-political and a formal legal point of view.

This article analyzes the problems encountered during the initial stage of the legal system of the British colony of Quebec and, in particular, of the sources of its territorial law.
Romana Laskowskiego koncepcja opisu kategorii rodzaju w języku polskim
Authors: Bobrowski Ireneusz
Published: June 2015

Roman Laskowski’s concept of grammatical gender in Polish

Probably the most elaborate intellectual construct in Roman Laskowski’s morphology is his schematic presentation of the bridgeheads linking grammatical gender in Polish nouns to verbs, adjectives, and numerals. Although it occupies just two pages of print, to complete this study Laskowski had to analyze thousands of syntactic diagnostic contexts. The present paper tries to recall and comment on Laskowski’s original concept of grammatical gender in Polish.
Jednostka najróżniejsze na tle operacji semantycznej stopniowania
Authors: Grochowski Maciej
Published: June 2015

The unit najróżniejsze ‘all sorts of’ against the background of the semantic operation of grading

The paper presents a detailed semantic and syntactic analysis of such linguistic units in Polish as różne, najróżniejsze, and a preliminary description of such units as przeróżne, najprzeróżniejsze. The following hypotheses are substantiated: 1. The adjectives różny, przeróżny are not gradable; 2. The sequences najróżniejsze, najprzeróżniejsze resemble the superlative form of adjectives, but are separate linguistic units, and not in fact superlatives.
Problemy z Rozmyślaniem przemyskim
Authors: Mika Tomasz
Published: June 2015

Problems with Rozmyślanie przemyskie. Formulating general judgements, and the multilayered structure of the mediaeval text

The paper analyses the largest Polish mediaeval apocrypha, Rozmyślanie przemyskie. Using this example, the author shows the difficulty of formulating general judgments about mediaeval texts with a multilayered structure. The differences between the subsequent versions of the text prove to be rather large in the case of Rozmyślanie przemyskie. For this reason, even the assignment of the monument’s language to a specific dialectal base may apply to no more than a single layer of the text and, as a result, Red Ruthenian features may be found to co-appear with Lesser Polish ones. The author proposes that Rozmyślanie przemyskie displays both the vestiges of the original structure of the text, and traits of a new structure introduced by the last copyist. It is him who gave a title to the text, divided it in two, and added a considerable part of section titles. Therefore, we need to revise our current view that the last copyist was responsible for no more than the introduction of multiple mistakes into the text, and for incorporating into it the voice that was originally located in the margins and between the lines.
O szczególnej pozycji spójnikowych predykatów asocjatywnych
Authors: Topolińska Zuzanna
Published: June 2015

On the special status of associative conjunction predicates

In the word class of conjunctions, the paper discerns: (a) exponents of associative predicates, i.e. predicates which connect/link events/propositions by way of a simple association, (b) exponents of temporal links between events, and (c) exponents of causal links between events.

The author discusses certain special uses of Polish associative predicates formalized as conjunctions, and concludes that they are also characteristic of the corresponding class of predicates in other languages. She emphasizes their domination in the oral communication and comments on their ability to appear in the secondary function of quasi-particles.
Interdependence and Performance: A Natural Experiment in Firm Scope
Authors: Natividad Gabriel , Rawley Evan
Published: June 2015

This paper shows how interdependencies influence performance following a reduction in firm scope. We test the predictions of the theory using detailed microdata on every Peruvian fishing firm before and after a regulatory ban on mackerel fishing, finding that a reduction in the scope of activities causes the productivity of firms’ legacy anchovy operations to fall sharply, before recovering in the long run. The results are most pronounced for firms with the strongest interdependencies between activities. Moreover, we find evidence that the persistence of the productivity decline is explicitly tied to a failure to adapt quickly following the ban. Consistent with our conceptual characterization, the evidence suggests that interdependencies between activities simultaneously create benefits as well as costs, but that costs are more persistent when the firm reduces its scope of activities.
Oral and enteral nutrition in dementia: an overview
Authors: Brooke Joanne , Ojo Omorogieva
Published: June 2015

The number of people currently living with dementia in the UK is estimated to be 850 000 and this is expected to rise to over 1 million by the year 2025. Dementia is a progressive terminal disease and the rate of decline is unique to each person; however, cognitive deterioration can be accelerated by undernutrition. This article discusses evidence-based approaches in the use of oral and enteral nutrition interventions for people living with dementia and ways to support their caregivers. The discussion of interventions to improve oral nutrition includes changes to the environment, support with feeding difficulties, nutritional supplements and education and training for caregivers.
Nurses' attitudes to assisted suicide: sociodemographic factors
Authors: Evans Luke
Published: June 2015

This literature review seeks to explore the factors that influence nurses' attitudes towards assisted suicide. A poll conducted by the Royal College of Nursing (RCN) showed that 49% of nurses supported assisted suicide while 40% were opposed to it. A literature review resulted in 16 articles being identified for data synthesis using a recognised critiquing framework. The articles revealed four key themes: nursing specialty, level of education, geographical location and religion. It was concluded that these four themes are key to understanding a nurse's attitude towards assisted suicide. Nursing staff need to be aware of their own influences on this topic, since they will inevitably be involved in the process in some way or another, in countries where assisted suicide has been legalised.
Influencing organisational culture: a leadership challenge
Authors: Muls Ann , Dougherty Lisa , Doyle Natalie , Shaw Clare , Soanes Louise , Stevens Anna-Marie
Published: June 2015

In the wake of the Francis report, the need for NHS trusts and hospitals to adopt a culture of learning, safety and transparency has been highlighted. This article considers different aspects of culture in health care, and hones in on the link between culture and safety for patients in putting the patient first, embedding the 6Cs and considering the options to measure and influence organisational culture. The article reflects more deeply on how leadership across all levels can influence and inspire change in organisational culture, ensuring that the patient remains the focus of any changes in care delivery.
Topical haemoglobin spray for diabetic foot ulceration
Authors: Bateman Sharon Dawn
Published: June 2015

The development and subsequent deterioration of diabetic foot ulceration (DFU) is a common occurrence across all healthcare divides, concerning all patient groups, age, gender and social environments. It increases demand on clinical resources and creates unnecessary hardship for patients. Chronic DFU is challenging to prevent and notoriously difficult to manage owing to the complex nature of the patient and the disease itself. The improvement of oxygenation to many chronic wound groups is gaining momentum across wound care; particularly in those wounds such as DFU that present with circulatory, oxygen-deficient scenarios.

Method:

A descriptive evaluation was undertaken in an acute clinical setting where a spray solution containing purified haemoglobin was used in a cohort of 20 patients who presented with chronic (>12 weeks) DFU. Standard wound care was undertaken by 18 health professionals with no changes to products, devices or practice before evaluation. All wounds received the addition of the product on eight set occasions over a 4-week period and the resulting data correlated in regards to the set outcomes of wound surface area reduction, ease of use, adverse events and patient acceptability.

Results:

At 4 weeks all wounds had demonstrated positive wound reduction, there were no adverse events, all patients and clinicians found the product acceptable and easy to use. Interestingly, although not a set outcome, all wounds commenced the evaluation with wound-bed slough present and at 4 weeks 100% were deemed slough free. At a further 4-week review no patients wounds had regressed.

Conclusion:

The incorporation of a haemoglobin spray solution within this cohort of DFU resulted in a positive improvement in wound healing and slough elimination. Further work in this area is recommended to increase the evidence.
Moving and handling techniques in the dental practice
Authors: Kemp Kerry , Webb Steve , Jevon Phil
Published: June 2015

In the fourth article relating to moving and handling, the authors discuss the common techniques when lifting or manoeuvering objects in the dental practice
How useful are morning meetings?
Authors: Talati Shilla
Published: June 2015

A morning meeting is the best chance to get all your colleagues together to discuss that particular day, and how the team can liaise together to create a successful, productive and efficient day at work
A guide to recruitment for dental nurses
Authors: Russell Kate
Published: June 2015

In this article, Kate Russell explains what steps employers take when they are recruiting and how you can increase your chances of getting the job that you want
Reflection. Part 5: informal and formal reflection
Authors: Fowler John
Published: June 2015

This article examines how you can help others to use reflection informally and also within a structured portfolio
Genotoxic effects of diazinon on human peripheral blood lymphocytes / Genotoksično djelovanje diazinona na limfocite ljudske periferne krvi
Authors: Muranli Fulya Dilek Gökalp , Kanev Martin , Ozdemir Kezban
Published: June 2015

The aim of this study was to evaluate the genetic damage in human peripheral blood lymphocytes following 24 and 48- hour exposure to a commercial diazinon formulation Basudin 60EM® at concentrations between 0.01 and 40 μg mL-1. For this purpose we used the micronucleus (MN), fluorescence in situ hybridization (FISH), and alkaline single cell gel electrophoresis (comet) assay. Diazinon significantly increased the frequency of micronucleated cells compared to control. Forty-eight-hour exposure increased this frequency even at lower concentrations (0.01-10 μg mL-1). The FISH results revealed aneugenic effects at 10 μg mL-1. The comet assay also confirmed DNA damage at concentrations between 10 and 40 μg mL-1. Our findings have confirmed the genotoxic potential of diazinon and its cytotoxic effect on human lymphocytes. The increased DNA damage in our study raises concern about the current assessment of the health risk posed by this pesticide and calls for a high level of caution in agricultural and household use.
ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy / Ponašanje nalik ADHD-u u potomaka ženki štakora izloženih niskim dozama klorpirifosa prije trudnoće
Authors: Grabovska Sofia , Salyha Yuriу
Published: June 2015

The aim of this study was to investigate how chronic low-dose chlorpyrifos exposure of female Wistar rats before and during pregnancy affects behavioural parameters in their offspring. Four months before pregnancy, we exposed three groups of rats to chlorpyrifos doses of 5, 10, and 15 mg kg-1 body weight every day for 30 days, whereas one group received a single 30 mg kg-1 dose on gestational day 6. When the offspring of the exposed rats grew up, we studied their anxiety rate, motor activity, and cognitive abilities using the respective behavioural tests: open field test, dark/light box, and the extrapolation escape test. The offspring of rats exposed before pregnancy had significantly higher activity rate than controls, and even showed motor agitation and hyperactivity signs. The offspring of rats exposed to the single dose had difficulties solving the extrapolation escape test and showed poorer short- and long-term memory performance. This confirmed that even pre-pregnancy chlorpyrifos exposure can cause neurobehavioral consequences in offspring. Even though the mechanisms of the observed changes remain unclear and need further investigation, these data seem alarming and may serve as an important argument for revising the terms of safe pesticide use
Modelling of copper(II) binding to pentapeptides related to atrial natriuretic factor using the 3χv connectivity index / Modeliranje vezivanja bakra(II) za pentapeptide povezane s atrijalnim natriuretičkim faktorom pomoću indeksa povezanosti 3χv
Authors: Miličević Ante , Raos Nenad
Published: June 2015

Using molecular graph theory we studied the binding of NSFRY-NH2 and 12 related pentapeptide amides to Cu(II) as a model system for atrial natriuretic factor (ANF) peptide interactions with copper. Linear regression models based on the valence connectivity index of the 3rd order (3χv) reproduced experimental stability constants (log β) for 1N, 2N, 3N, and 4N coordinated complexes with the standard error of 0.30-0.39 log β units. We developed separate models for seven tyrosinic (N=28) and five non-tyrosinic peptides (N=20), and a common model for both kinds of peptides (N=48) with an indicator (dummy) variable. The results indicate additional aromatic stabilisation in 4N complexes due to metal cation-π interactions with tyrosine but not with the phenylalanine residue. We have also amended the log K and log K* values to correct miscalculations published by Janicka-Klos et al. in 2013
On-line parameter and delay estimation of continuous-time dynamic systems
Authors: Kozłowski Janusz , Kowalczuk Zdzisław
Published: June 2015

The problem of on-line identification of non-stationary delay systems is considered. The dynamics of supervised industrial processes are usually modeled by ordinary differential equations. Discrete-time mechanizations of continuous-time process models are implemented with the use of dedicated finite-horizon integrating filters. Least-squares and instrumental variable procedures mechanized in recursive forms are applied for simultaneous identification of input delay and spectral parameters of the system models. The performance of the proposed estimation algorithms is verified in an illustrative numerical simulation study.
Using symbolic computation in the characterization of frictional instabilities involving orthotropic materials
Authors: Agwa Mohamed A. , Pinto Da Costa António
Published: June 2015

The present work addresses the problem of determining under what conditions the impending slip state or the steady sliding of a linear elastic orthotropic layer or half space with respect to a rigid flat obstacle is dynamically unstable. In other words, we search the conditions for the occurrence of smooth exponentially growing dynamic solutions with perturbed initial conditions arbitrarily close to the steady sliding state, taking the system away from the equilibrium state or the steady sliding state. Previously authors have shown that a linear elastic isotropic half space compressed against and sliding with respect to a rigid flat surface may get unstable by flutter when the coefficient of friction μ and Poisson’s ratio ν are sufficiently large. In the isotropic case they have been able to derive closed form analytic expressions for the exponentially growing unstable solutions as well as for the borders of the stability regions in the space of parameters, because in the isotropic case there are only two dimensionless parameters (μ and ν). Already for the simplest version of orthotropy (an orthotropic transversally isotropic material) there are seven governing parameters (μ, five independent material constants and the orientation of the principal directions of orthotropy) and the expressions become very lengthy and literally impossible to manipulate manually. The orthotropic case addressed here is impossible to solve with simple closed form expressions, and therefore the use of computer algebra software is required, the main commands being indicated in the text.
Local dependency in networks
Authors: Kudĕlka Miloš , Zehnalová Šárka , Horák Zdenĕk , Krömer Pavel , Snášel Václav
Published: June 2015

Many real world data and processes have a network structure and can usefully be represented as graphs. Network analysis focuses on the relations among the nodes exploring the properties of each network. We introduce a method for measuring the strength of the relationship between two nodes of a network and for their ranking. This method is applicable to all kinds of networks, including directed and weighted networks. The approach extracts dependency relations among the network’s nodes from the structure in local surroundings of individual nodes. For the tasks we deal with in this article, the key technical parameter is locality. Since only the surroundings of the examined nodes are used in computations, there is no need to analyze the entire network. This allows the application of our approach in the area of large-scale networks. We present several experiments using small networks as well as large-scale artificial and real world networks. The results of the experiments show high effectiveness due to the locality of our approach and also high quality node ranking comparable to PageRank.
Event monitoring of parallel computations
Authors: Gruzlikov Alexander M. , Kolesov Nikolai V. , Tolmacheva Marina V.
Published: June 2015

The paper considers the monitoring of parallel computations for detection of abnormal events. It is assumed that computations are organized according to an event model, and monitoring is based on specific test sequences
Can interestingness measures be usefully visualized?
Authors: Susmaga Robert , Szczęch Izabela
Published: June 2015

The paper presents visualization techniques for interestingness measures. The process of measure visualization provides useful insights into different domain areas of the visualized measures and thus effectively assists their comprehension and selection for different knowledge discovery tasks. Assuming a common domain form of the visualized measures, a set of contingency tables, which consists of all possible tables having the same total number of observations, is constructed. These originally four-dimensional data may be effectively represented in three dimensions using a tetrahedron-based barycentric coordinate system. At the same time, an additional, scalar function of the data (referred to as the operational function, e.g., any interestingness measure) may be rendered using colour. Throughout the paper a particular group of interestingness measures, known as confirmation measures, is used to demonstrate the capabilities of the visualization techniques. They cover a wide spectrum of possibilities, ranging from the determination of specific values (extremes, zeros, etc.) of a single measure, to the localization of pre-defined regions of interest, e.g., such domain areas for which two or more measures do not differ at all or differ the most.
A generalization of the graph Laplacian with application to a distributed consensus algorithm
Authors: Zhai Guisheng
Published: June 2015

In order to describe the interconnection among agents with multi-dimensional states, we generalize the notion of a graph Laplacian by extending the adjacency weights (or weighted interconnection coefficients) from scalars to matrices. More precisely, we use positive definite matrices to denote full multi-dimensional interconnections, while using nonnegative definite matrices to denote partial multi-dimensional interconnections. We prove that the generalized graph Laplacian inherits the spectral properties of the graph Laplacian. As an application, we use the generalized graph Laplacian to establish a distributed consensus algorithm for agents described by multi-dimensional integrators.
An application framework to systematically develop complex learning resources based on collaborative knowledge engineering
Authors: Gañán David , Caballé Santi , Conesa Jordi , Xhafa Fatos
Published: June 2015

This contribution proposes software infrastructure to support new types of learning methodologies and resources based on collaborative knowledge engineering by means of an innovative application framework called the virtualized collaborative sessions framework (VCSF). The VCSF helps meet challenging collaborative knowledge engineering requirements in online learning, such as increasing group members’ learning performance during the on-line collaborative learning process. In turn, systematic application of the VCSF platform enriched with semantic knowledge engineering technologies enables e-learning developers to leverage successful collaborative learning experiences in a software reuse fashion while saving development time and effort. The framework is prototyped and successfully tested in real environments, thus showing the software reuse capability and the collaborative knowledge engineering benefits of the VCSF approach. The research reported in this paper was undertaken within the ALICE project funded through the European 7th Framework Program (FP7).
Sender-equivocable encryption schemes secure against chosen-ciphertext attacks revisited
Authors: Huang Zhengan , Liu Shengli , Qin Baodong , Chen Kefei
Published: June 2015

Fehr et al. (2010) proposed the first sender-equivocable encryption scheme secure against chosen-ciphertext attacks (NCCCA) and proved that NC-CCA security implies security against selective opening chosen-ciphertext attacks (SO-CCA). The NC-CCA security proof of the scheme relies on security against substitution attacks of a new primitive, the “crossauthentication code”. However, the security of the cross-authentication code cannot be guaranteed when all the keys used in the code are exposed. Our key observation is that, in the NC-CCA security game, the randomness used in the generation of the challenge ciphertext is exposed to the adversary. Based on this observation, we provide a security analysis of Fehr et al.’s scheme, showing that its NC-CCA security proof is flawed. We also point out that the scheme of Fehr et al. encrypting a single-bit plaintext can be refined to achieve NC-CCA security, free of the cross-authentication code. Furthermore, we propose the notion of “strong cross-authentication code”, apply it to Fehr et al.’s scheme, and show that the new version of the latter achieves NC-CCA security for multi-bit plaintexts.