bluuebunny/crossref_metadata_2025 huggingface dataset:
HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy
Authors: Mangraviti Antonella , Raghavan Tula , Volpin Francesco , Skuli Nicolas , Gullotti David , Zhou Jinyuan , Asnaghi Laura , Sankey Eric , Liu Ann , Wang Yuan , Lee Dong-Hoon , Gorelick Noah , Serra Riccardo , Peters Michael , Schriefer Destiny , Delaspre Fabien , Rodriguez Fausto J. , Eberhart Charles G. , Brem Henry , Olivi Alessandro , Tyler Betty
Published: October 2017

Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encouraging preclinical and clinical results in solid tumors. Here we describe the efficacy of a HIF-1α inhibitor, Acriflavine, and demonstrate its potency against brain cancer. This safe antibacterial dye induces cell death and apoptosis in several glioma cell lines, targets HIF-1α–mediated pathways, and decreases the level of PGK1, VEGF and HIF-1α in vitro and in vivo. Administered locally via biodegradable polymers, Acriflavine provides significant benefits in survival resulting in nearly 100% long term survival, confirmed by MRI and histological analyses. This study reports preclinical evidence that this safe, small molecule can contribute to brain tumor therapy and highlights the significance of HIF-1α-targeting molecules.
Two-dimensional negative capacitance transistor with polyvinylidene fluoride-based ferroelectric polymer gating
Authors: Wang Xudong , Chen Yan , Wu Guangjian , Li Dan , Tu Luqi , Sun Shuo , Shen Hong , Lin Tie , Xiao Yongguang , Tang Minghua , Hu Weida , Liao Lei , Zhou Peng , Sun Jinglan , Meng Xiangjian , Chu Junhao , Wang Jianlu
Published: October 2017

Conventional field-effect transistors (FETs) are not expected to satisfy the requirements of future large integrated nanoelectronic circuits because of these circuits’ ultra-high power dissipation and because the conventional FETs cannot overcome the subthreshold swing (SS) limit of 60 mV/decade. In this work, the ordinary oxide of the FET is replaced only by a ferroelectric (Fe) polymer, poly(vinylidene difluoride-trifluoroethylene) (P(VDF-TrFE)). Additionally, we employ a two-dimensional (2D) semiconductor, such as MoS2 and MoSe2, as the channel. This 2D Fe-FET achieves an ultralow SS of 24.2 mV/dec over four orders of magnitude in drain current at room temperature; this sub-60 mV/dec switching is derived from the Fe negative capacitance (NC) effect during the polarization of ferroelectric domain switching. Such 2D NC-FETs, realized by integrating of 2D semiconductors and organic ferroelectrics, provide a new approach to satisfy the requirements of next-generation low-energy-consumption integrated nanoelectronic circuits as well as the requirements of future flexible electronics.
A compendium of multi-omic sequence information from the Saanich Inlet water column
Authors: Hawley Alyse K. , Torres-Beltrán Mónica , Zaikova Elena , Walsh David A. , Mueller Andreas , Scofield Melanie , Kheirandish Sam , Payne Chris , Pakhomova Larysa , Bhatia Maya , Shevchuk Olena , Gies Esther A. , Fairley Diane , Malfatti Stephanie A. , Norbeck Angela D. , Brewer Heather M. , Pasa-Tolic Ljiljana , del Rio Tijana Glavina , Suttle Curtis A. , Tringe Susannah , Hallam Steven J.
Published: October 2017

Marine oxygen minimum zones (OMZs) are widespread regions of the ocean that are currently expanding due to global warming. While inhospitable to most metazoans, OMZs are hotspots for microbial mediated biogeochemical cycling of carbon, nitrogen and sulphur, contributing disproportionately to marine nitrogen loss and climate active trace gas production. Our current understanding of microbial community responses to OMZ expansion is limited by a lack of time-resolved data sets linking multi-omic sequence information (DNA, RNA, protein) to geochemical parameters and process rates. Here, we present six years of time-resolved multi-omic observations in Saanich Inlet, a seasonally anoxic fjord on the coast of Vancouver Island, British Columbia, Canada that undergoes recurring changes in water column oxygenation status. This compendium provides a unique multi-omic framework for studying microbial community responses to ocean deoxygenation along defined geochemical gradients in OMZ waters.
Anti-leishmanial Drug Discovery: Past, Present and Future Perspectives
Authors: Mowbray Charles E.
Published: October 2017

The drugs currently used for treating leishmaniasis suffer from limitations in efficacy and safety and are not well adapted to the needs of patients. Combining these drugs has led to improvements in efficacy and safety in some geographical regions, but many patients are still in need of more effective, safer and more convenient treatments. The existing drugs for leishmaniasis were re-purposed from other therapeutic indications and are far from optimal, relying largely on painful intravenous and intramuscular injections, with the exception of miltefosine, which is orally active. In recent years, orally-acting new chemical entities have been designed and selected for development for treating visceral leishmaniasis and also have potential for the cutaneous form of the disease. These new drug classes have been discovered using phenotypic drug discovery methods and offer great promise for developing new treatments, but their mechanisms of action are often not well understood. Efforts to de-convolute the mechanisms of action of these candidates and newer target-based drug discovery approaches should open the door for discovery of further drug classes and candidate molecules. This chapter describes the evolution of drug discovery approaches for leishmaniasis, explores the properties of emerging drug candidates and considers the potential for these efforts to deliver new treatments to patients.
The Pursuit of Novel Anti-leishmanial Agents by High-throughput Screening (HTS) of Chemical Libraries
Authors: Martin Julio , Cantizani Juan , Peña Imanol
Published: October 2017

In this chapter we review screening methodologies and concepts that have been applied to discover new anti-leishmanial compounds within large chemical libraries. There is a consensus regarding the need for more efficacious, safer and inexpensive oral drugs for the treatment of leishmaniasis. For the sake of unprecedented novelty, the pursuit of new chemical entities (NCEs) starts with the screening of molecules of unknown activity. High-throughput screening (HTS) has become the classical approach to interrogate large chemical libraries (i.e. from hundreds of thousands to a few millions compounds) in a time- and cost-effective manner. HTS against Leishmania has meant a challenge to develop and implement the right assays and selection tactics. Biosafety, life-cycle stage of the parasite (i.e. promastigotes vs. amastigotes), culture conditions (i.e. axenic vs. intracellular) and source of host cells (i.e. immortalized cells vs. primary macrophages) have been some of the issues addressed in order to make compatible both biological relevance and do-ability. Herewith we walk the reader through different solutions adopted and implemented by the scientific community in the field.
Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs
Authors: Martinez Ana , Gil Carmen
Published: October 2017

Leishmaniasis is a major public health problem faced by many countries. The available treatments are less than optimal due to significant limitations, such as the toxicity of the drugs used or the emergence of resistant strains. Thus, discovery and development of novel drug candidates with better pharmacological profiles are still required. Among the different strategies to discover new drugs, natural products and privileged structures are without any doubt excellent starting points for the rational design of drug candidates. Nowadays, selection of compounds from different sources based on target-based and/or whole-cell assays, together with repurposing of approved drugs, provides promising candidates to be developed as future drugs for the treatment of this neglected disease.
Natural Products as a Source of New Drugs Against Leishmania
Authors: Lago João Henrique G. , Tempone Andre G.
Published: October 2017

Leishmaniasis is a tropical disease caused by protozoan parasites of the genus Leishmania and represents a public health problem worldwide, affecting millions of people especially in developing countries. The current therapeutic arsenal includes a limited range of drugs with high toxicity and moderate efficacy, especially for immunocompromised patients. Therefore, the discovery of new compounds to be used as scaffolds for the development of new drug candidates is crucial. Some recent works have demonstrated the potential of natural products as a rich source for the selection of new hit and lead compounds for leishmaniasis, but essentially, these works are limited to in vitro assays. In this chapter, rational approaches to be used in drug discovery studies involving natural products and Leishmania are described, together with an overview focused on secondary metabolites (alkaloids, terpenoids, saponins, phenylpropanoids, flavonoids, lignoids, naphtoquinones and iridoids) isolated from different sources (plants, microorganisms, marine organisms, etc.) with in vivo potential against Leishmania spp.
Addressing the Molecular Biology of Leishmania for Drug Development
Authors: Norris-Mullins Brianna , Morales Miguel A.
Published: October 2017

Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania. More than 20 Leishmania species infect humans and the disease is endemic in several areas of the Old and New World. Existing therapies for leishmaniasis are inadequate due to resistance, safety and cost, underscoring the necessity for safer therapies with alternative modes of action. The entry of molecular biology with its elucidation of the genomics and proteomics of these organisms has provided increasingly sophisticated explanations of their unique mechanisms to adapt to intense environmental pressures. An interesting feature of the Leishmania (and other trypanosomatids) genome is the unusual nature of transcription and RNA processing. Protein-coding genes are organized into long gene clusters, and the resulting polycistronic RNAs are post-transcriptionally processed into mature mRNAs by concomitant trans-splicing and polyadenylation. These and other unique features are not shared with its host, thus offering new and exciting new avenues for therapeutic intervention.
Carbon Metabolism as a Drug Target in Leishmania
Authors: Acosta Héctor , Yuan Meng , Cáceres Ana J. , Quiñones Wilfredo A. , Luis Concepción Juan , Michels Paul A. M.
Published: October 2017

Several pathways of carbon metabolism, or parts of them, play important roles in the proliferation and virulence of the human pathogenic stage of Leishmania, the intracellular amastigotes. Kinetic and structural properties of a considerable number of enzymes from this metabolic network from Leishmania spp. and/or related Trypanosoma spp. have been studied in detail and compared with the enzymes catalysing the corresponding reactions in human. This has allowed the identification of parasite-enzyme-specific features. Potent and selective inhibitors of the trypanosomatid enzymes have been developed to exploit these unique properties. Some of these compounds stunt the proliferation of parasites, including the intracellular Leishmania amastigotes, without affecting growth of host cell lines, and/or affect their virulence in infected animal models.
Recent advances in the use of microfluidic technologies for single cell analysis
Authors: Murphy Travis W. , Zhang Qiang , Naler Lynette B. , Ma Sai , Lu Chang
Published: October 2017

We present a review on recent advances in single cell analysis based on microfluidic platforms.
Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells
Authors: Ino Kosuke , Şen Mustafa , Shiku Hitoshi , Matsue Tomokazu
Published: October 2017

This review summarizes recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells.
A carboxylated graphene nanodisks/glucose oxidase nanotags and Mn:CdS/TiO2 matrix based dual signal amplification strategy for ultrasensitive photoelectrochemical detection of tumor markers
Authors: Song Jie , Wu Shuo , Yang Xinlan , Yuan Jingli
Published: October 2017

A graphene nanodisk and glucose oxidase based dual signal amplification strategy was developed for a highly sensitive PEC immunoassay of CEA.
Chemical modification of antibodies enables the formation of stable antibody–gold nanoparticle conjugates for biosensing
Authors: Filbrun Seth L. , Filbrun Alexandra B. , Lovato Francis L. , Oh Soon H. , Driskell Elizabeth A. , Driskell Jeremy D.
Published: October 2017

Antibody-modified gold nanoparticles (AuNPs) are central to many novel and emerging biosensing technologies due to the specificity provided by antibody–antigen interactions and the unique properties of nanoparticles.
SmartIHC-Analyzer: smartphone assisted microscopic image analytics for automated Ki-67 quantification in breast cancer evaluation
Authors: Tewary Suman , Arun Indu , Ahmed Rosina , Chatterjee Sanjoy , Chakraborty Chandan
Published: October 2017

As with other cancers, cell proliferation is one of the indicative hallmarks of breast cancer evaluation. The expression of human Ki-67, being a nuclear protein, has strong association with the proliferation of cancer cells.
Measurement of 14N quadrupole couplings in biomolecular solids using indirect-detection 14N solid-state NMR with DNP
Authors: Jarvis J. A. , Haies I. , Lelli M. , Rossini A. J. , Kuprov I. , Carravetta M. , Williamson P. T. F.
Published: October 2017

Insights into protein structure through the determination of 14N quadrupolar interactions using magic-angle spinning dynamic nuclear polarization NMR.
A look at the density functional theory zoo with the advanced GMTKN55 database for general main group thermochemistry, kinetics and noncovalent interactions
Authors: Goerigk Lars , Hansen Andreas , Bauer Christoph , Ehrlich Stephan , Najibi Asim , Grimme Stefan
Published: October 2017

We present the updated and extended GMTKN55 benchmark database for more accurate and extensive energetic evaluation of density functionals and other electronic structure methods with detailed guidelines for method users.
Photodissociation of the CH3O and CH3S radical molecules: an ab initio electronic structure study
Authors: Bouallagui A. , Zanchet A. , Yazidi O. , Jaïdane N. , Bañares L. , Senent M. L. , García-Vela A.
Published: October 2017

Potential-energy surfaces and spin–orbit couplings involved in the photodissociation of the CH3O and CH3S radicals have been investigated.
A direct dynamics study of the deprotonated guanine·cytosine base pair: intra-base pair proton transfer, thermal dissociation vs. collision-induced dissociation, and comparison with experiment
Authors: Liu Jianbo
Published: October 2017

Dynamics of intra-base pair hydrogen bonds upon random thermal excitation vs. non-random collisional activation.
Access to the meta position of arenes through transition metal catalysed C–H bond functionalisation: a focus on metals other than palladium
Authors: Mihai Madalina T. , Genov Georgi R. , Phipps Robert J.
Published: October 2017

The elaboration of simple arenes in order to access more complex substitution patterns is a crucial endeavor for synthetic chemists, given the central role that aromatic rings play in all manner of important molecules.
Co embedded within biomass-derived mesoporous N-doped carbon as an acid-resistant and chemoselective catalyst for transfer hydrodeoxygenation of biomass with formic acid
Authors: Yang Huanhuan , Nie Renfeng , Xia Wang , Yu Xiaolong , Jin Dingfeng , Lu Xinhuan , Zhou Dan , Xia Qinghua
Published: October 2017

Biomass-derived acid-resistant Co@NC is used as a bifunctional catalyst for biomass-derived FA dehydrogenation and biomass-derived vanillin hydrodeoxygenation.
Polarization energy of two charged dielectric spheres in close contact
Authors: Lian Huada , Qin Jian
Published: October 2017

Cohesive energy of charged dielectric spheres in close contact.
Carbo[5]helicene versus planar phenanthrene as a scaffold for organic materials in OLEDs: the electroluminescence of anthracene-functionalized emissive materials
Authors: Jhulki Samik , Mishra Abhaya Kumar , Chow Tahsin J. , Moorthy Jarugu Narasimha
Published: October 2017

Rigid and twisted carbo[5]helicene imparts better physical and electroluminescence properties than planar phenantherene for phenylanthracene-functionalized emissive materials.
Cyanide bridged coordination polymer nanoflakes thermally derived Ni3C and fcc-Ni nanoparticles for electrocatalysts
Authors: Zakaria Mohamed B. , Ebeid El-Zeiny M. , Abdel-Galeil Mohamed M. , Chikyow Toyohiro
Published: October 2017

We have reported a controlled crystal growth process, which allows the formation of NiCNNi CP nanoflakes derived Ni3C and fcc-Ni nanoparticles.
Charge-reversible and pH-responsive biodegradable micelles and vesicles from linear-dendritic supramolecular amphiphiles for anticancer drug delivery
Authors: Huang Da , Wang Yaqiang , Yang Fei , Shen Hong , Weng Zuquan , Wu Decheng
Published: October 2017

The linear-dendritic supramolecular amphiphiles could assemble into charge-reversible and pH-responsive biodegradable micelles and vesicles.
Phenyl carbamate functionalized zinc oxide nanorods for paper-based thin film microextraction
Authors: Saraji Mohammad , Mehrafza Narges
Published: October 2017

In this work, phenyl carbamate functionalized zinc oxide nanorods were fabricated on a cellulose filter paper and employed as a novel and low cost sorbent in a thin film microextraction (TFME) technique.
Concise synthesis of the pyruvic acid acetal containing pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O156
Authors: Si Anshupriya , Misra Anup Kumar
Published: October 2017

The pentasaccharide repeating unit of the cell wall O-antigen ofEscherichia coliO156 containing 4,6-O-(R)-pyruvate acetal was synthesized using stereoselective [2 + 3] block glycosylation in satisfactory yield.
Development of supramolecular solvent based microextraction prior to high performance liquid chromatography for simultaneous determination of phenols in environmental water
Authors: Seebunrueng Ketsarin , Dejchaiwatana Chaiyawat , Santaladchaiyakit Yanawath , Srijaranai Supalax
Published: October 2017

SUPRAS based microextraction for phenols.
Role of lanthanum vacancy on the structural, magnetic and magnetocaloric properties in the lacunar perovskite manganites La0.8−x□xNa0.2MnO3(0 ≤ x ≤ 0.15)
Authors: Choura-Maatar S. , M’nassri R. , Cheikhrouhou-Koubaa W. , Koubaa M. , Cheikhrouhou A. , Hlil E. K.
Published: October 2017

Lacunar La0.8−x□xNa0.2MnO3(0 ≤x≤ 0.15) ceramics where □ is a lanthanum deficiency were synthesizedviaa sol–gel method.
Low-temperature chemical vapor deposition of cobalt oxide thin films from a dicobaltatetrahedrane precursor
Authors: Melzer Marcel , Nichenametla Charan K. , Georgi Colin , Lang Heinrich , Schulz Stefan E.
Published: October 2017

Application of a novel liquid cobalt precursor, which forms cobalt oxide films at low temperatures using relatively simple CVD process.
HCl post-processing BiOBr photocatalyst: structure, morphology, and composition and their impacts to activity
Authors: Hu Min , Li Rui , Zhang Xiaochao , Zhang Changming , Zhang Hui , Fan Caimei , Zhu Jesse
Published: October 2017

This work reports a systematic investigation on the structure, morphology, and composition, and their impacts on photocatalytic performance, for a HCl post-processing BiOBr photocatalyst.
Molecular recognition of pyruvic acid and folic acid in whole blood
Authors: Stefan-van Staden Raluca-Ioana , Diaconeasa Amalia Gabriela , Gugoasa Livia Alexandra , Rosu Marcela-Corina , Pruneanu Stela
Published: October 2017

Cyclodextrins immobilized in TiO2Pt–graphene nanocomposite paste simultaneously detect folic and pyruvic acids in whole blood samples.
Optically active blue-emitting carbon dots to specifically target the Golgi apparatus
Authors: Yuan Mengke , Guo Yanjia , Wei Jianjia , Li Jizhou , Long Tengfei , Liu Zhongde
Published: October 2017

A pair of optically active carbon dots were prepared, which could specifically target and directly illuminate the Golgi apparatus.
Self-crosslink assisted synthesis of 3D porous branch-like Fe3O4/C hybrids for high-performance lithium/sodium-ion batteries
Authors: Wang Ning , Liu Qinglei , Li Yue , Chen Jichao , Gu Jiajun , Zhang Wang , Zhang Di
Published: October 2017

Porous branch-like Fe3O4/C hybrids synthesized by a simple carbonization of self-crosslinked Fe-alginate show high-performance in lithium/sodium-ion batteries.
The facile preparation of Ag decorated TiO2/ZnO nanotubes and their potent photocatalytic degradation efficiency
Authors: Zhao Shengzhe , Cheng Zhiqiang , Kang Lijuan , Li Mingtang , Gao Zhiling
Published: October 2017

An illustration of the formation mechanism of Ag/TiO2/ZnO nanotubes.
A ternary composite oxides S2O82−/ZrO2–TiO2–SiO2 as an efficient solid super acid catalyst for depolymerization of lignin
Authors: Wang Huizhen , Li Wenzhi , Wang Jindong , Chang Hou-min , Jameel Hasan , Zhang Qi , Li Song , Jin Lele
Published: October 2017

The solid, super, acid catalyst S2O82−/ZrO2–TiO2–SiO2, which has both a strong Brønsted acid and Lewis acid, was prepared and applied in lignin depolymerization.
Electrostatically driven scalable synthesis of MoS2–graphene hybrid films assisted by hydrophobins
Authors: Kaur Jasneet , Vergara Alessandro , Rossi Manuela , Gravagnuolo Alfredo Maria , Valadan Mohammadhassan , Corrado Federica , Conte Mariarosaria , Gesuele Felice , Giardina Paola , Altucci Carlo
Published: October 2017

Green synthesis of MoS2/biofunctionalized graphene hybrid films assisted by Vmh2 hydrophobin for applications in biosensing and photodetection.
Establishment of a rapid and sensitive method based on recombinase polymerase amplification to detect mts90, a new molecular target of Mycobacterium tuberculosis
Authors: Mo Yunjun , Cui Fang , Li Dairong , Dai Yi , Li Xinmin , Zhang Xinyuan , Qiu Yulan , Yin Yibing , Zhang Xuemei , Xu Wenchun
Published: October 2017

The paper is about rapid screening of tuberculosis for detecting mts90, a new molecular target ofMycobacterium tuberculosis.
High-pressure synthesis, crystal structure and photoluminescence properties of a new terbium silicate: Na2Tb1.08Ca2.92Si6O18H0.8
Authors: Bao Xinjian , Liu Xiaoyang , Liu Xi
Published: October 2017

New terbium silicate Na2Tb1.08Ca2.92Si6O18H0.8 was synthesized at high pressure condition. The structure was and the photoluminescence properties were also investigated suggesting a strong green emission with the lifetime 2.498(7) ms.
Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging
Authors: Basal Lina A. , Bailey Matthew D. , Romero Jonathan , Ali Meser M. , Kurenbekova Lyazat , Yustein Jason , Pautler Robia G. , Allen Matthew J.
Published: October 2017

Mechanistically unique 19F-EuII/III complex reports redox in vivo using both 1H- and 19F-MRI and displays temperature-dependent contrast enhancement.
Rational design of exfoliated 1T MoS2@CNT-based bifunctional separators for lithium sulfur batteries
Authors: Jeong Y. C. , Kim J. H. , Kwon S. H. , Oh J. Y. , Park J. , Jung Y. , Lee S. G. , Yang S. J. , Park C. R.
Published: October 2017

1T exfoliated MoS2@CNT-based bifunctional separators in a tandem configuration delivered excellent electrochemical performance, and rational guidelines for preparing bifunctional separators for lithium sulfur batteries were suggested.
Large-diameter light-scattering complex multipodal nanotubes with graded refractive index: insights into their formation mechanism and photoelectrochemical performance
Authors: Omar Mostafa M. , Fawzy Samar M. , El-Shabasy Adel B. , Allam Nageh K.
Published: October 2017

Nanostructuring, morphology tuning, doping, as well as alloying have decisive roles in controlling the performance of functional materials.
Synergy effect of specific electrons and surface plasmonic resonance enhanced visible-light photoelectrochemical sensing for sensitive analysis of the CaMV 35S promoter
Authors: Li Henan , Zhu Mingyue , Wang Shanshan , Chen Wei , Liu Qian , Qian Jing , Hao Nan , Wang Kun
Published: October 2017

A Ag/TiO2/N-GNR ternary composite-based photoelectrochemical sensor for sensitive analysis of the CaMV 35S promoter.
Tuning the electronic and quantum transport properties of nitrogenated holey graphene nanoribbons
Authors: Saraiva-Souza Aldilene , Smeu Manuel , da Silva Filho José Gadelha , Girão Eduardo Costa , Guo Hong
Published: October 2017

Strong negative differential resistance (NDR) behavior with a remarkable current peak-to-valley ratio for armchair C2N-hNRs and non-linear current–voltage characteristics for zigzag C2N-hNRs.
Predicting Intelligibility Gains in Individuals With Dysarthria From Baseline Speech Features
Authors: Fletcher Annalise R. , McAuliffe Megan J. , Lansford Kaitlin L. , Sinex Donal G. , Liss Julie M.
Published: October 2017

Purpose

Across the treatment literature, behavioral speech modifications have produced variable intelligibility changes in speakers with dysarthria. This study is the first of two articles exploring whether measurements of baseline speech features can predict speakers’ responses to these modifications.

Methods

Fifty speakers (7 older individuals and 43 speakers with dysarthria) read a standard passage in habitual, loud, and slow speaking modes. Eighteen listeners rated how easy the speech samples were to understand. Baseline acoustic measurements of articulation, prosody, and voice quality were collected with perceptual measures of severity.

Results

Cues to speak louder and reduce rate did not confer intelligibility benefits to every speaker. The degree to which cues to speak louder improved intelligibility could be predicted by speakers' baseline articulation rates and overall dysarthria severity. Improvements in the slow condition could be predicted by speakers' baseline severity and temporal variability. Speakers with a breathier voice quality tended to perform better in the loud condition than in the slow condition.

Conclusions

Assessments of baseline speech features can be used to predict appropriate treatment strategies for speakers with dysarthria. Further development of these assessments could provide the basis for more individualized treatment programs.
3D AUTOCUT: a 3D segmentation algorithm based on cellular automata
Authors: Neto E.C. , Cortez P.C. , Rodrigues V.E. , Cavalcante T.S. , Valente I.R.S.
Published: October 2017

An improved 3D cellular automaton segmentation algorithm is proposed. The purpose is to create a tri‐directional automaton in order to segment 3D volumes. The improvement is that a force is created in the RGB space in order to improve the result of the 3D algorithm. Experiments on several synthetic volumes have shown that the proposed method achieves better segmentation results and efficiency than the other methods.
Using context from inside‐out vision for improved activity recognition
Authors: Noor Shaheena , Uddin Vali
Published: October 2017

The authors propose a method to improve activity recognition by including the contextual information from first person vision (FPV). Adding the context, i.e. objects seen while performing an activity, increases the activity recognition precision. This is because, in goal‐oriented tasks, human gaze precedes the action and tends to focus on relevant objects. They extract object information from FPV images and combine it with the activity information from external or FPV videos to train an Artificial Neural Network (ANN). They used four configurations as combination of gaze/eye‐tracker, head‐mounted and externally mounted cameras using three standard cooking datasets from Georgia Tech Egocentric Activities Gaze, Technische Universität München kitchen and CMU multi‐modal activity database. Adding object information when training the ANN increased the precision and accuracy of activity recognition from average 58.02% (and 89.78%) to 74.03% (and 93.42%). Experiments also showed that when objects are not considered, having an external camera is necessary. However, when objects are considered, the combination of internal and external cameras is optimal because of their complementary advantages in observing hand and objects. Adding object information also decreases ANN training cycles from 513.25 to 139, which shows that it provides critical information that speeds up training.
Privacy issues in social networks and analysis: a comprehensive survey
Authors: Pham Vu Viet Hoang , Yu Shui , Sood Keshav , Cui Lei
Published: October 2017

Social networks have become part of today's life; however, they also create numerous privacy problems for their users as they reveal sensitive information. Thus, the privacy preservation has become a big problem in social networks and there are several researches related to this topic. However, the current research achievements for this issue are only ad hoc solutions and the broad picture of the problem is not clear. This paper surveys a wide range of related researches and realises that the topic includes many sub‐areas; for example, the privacy in publishing social network data for the use of third‐party consumers or the privacy of users in the leakage of individuals’ information to unexpected people in their social circle. The study also analyses the advantages as well as limitations of proposed solutions. On the basis of that the research outlines key outstanding issues and recommends directions for the future research. Moreover, the research also investigates common privacy metrics and popular privacy‐preserving techniques to provide readers some basic tools to resolve open problems in the topic. The ultimate purpose of this research is to pave a solid background for people, who are interested in the topic, to do research further.
Galaxy evolution in groups
Authors: Mazzei P. , Marino A. , Rampazzo R. , Plana H. , Rosado M. , Arias L.
Published: October 2017

Context. Local Group (LG) analogs (LGAs) are galaxy associations dominated by a few bright spirals reminiscent of the LG. The NGC 3447/NGC 3447A system is a member of the LGG 225 group, a nearby LGA. This system is considered a physical pair composed of an intermediate-luminosity late-type spiral, NGC 3447 itself, and an irregular companion, NGC 3447A, linked by a faint, short filament of matter. A ring-like structure in the NGC 3447 outskirts has been emphasised by Galaxy Evolution Explorer (GALEX) observations.

Aims. This work aims to contribute to the study of galaxy evolution in low-density environments, a favourable habitat to highly effective encounters, shedding light on the evolution of the NGC 3447/NGC 3447A system.

Methods. We performed a multi-λ analysis of the surface photometry of this system to derive its spectral energy distribution and structural properties using ultraviolet (UV), Swift UVOT, and optical Sloan Digital Sky Survey (SDSS) images complemented with available far-IR observations. We also characterised the velocity field of the pair using two-dimensional Hα kinematical observations of the system obtained with PUMA Fabry-Perot interferometer at the 2.1 m telescope of San Pedro Mártir (Mexico). All these data are used to constrain smooth particle hydrodynamic simulations with chemo-photometric implementation to shed light on the evolution of this system.

Results. The luminosity profiles, from UV to optical wavelengths, are all consistent with the presence of a disc extending and including NGC 3447A. The overall velocity field does not emphasise any significant rotation pattern, rather a small velocity gradient between NGC 3447 and NGC 3447A. Our simulation, detached from a large grid explored to best-fit the global properties of the system, suggests that this arises from an encounter between two halos of equal mass.

Conclusions. NGC 3447 and NGC 3447A belong to the same halo, NGC 3447A being a substructure of the same disk including NGC 3447. The halo gravitational instability, enhanced by the encounter, fuels a long-lived instability in this dark-matter-dominated disk, driving the observed morphology. The NGC 3447/NGC 3447A system may warn of a new class of “false pairs” and the potential danger of a misunderstanding of such objects in pair surveys that could produce a severe underestimate of the total mass of a system.
Oxidative Biaryl Coupling of N-Aryl Anilines by Using a Hypervalent Iodine(III) Reagent
Authors: Morimoto Koji , Koseki Doichi , Dohi Toshifumi , Kita Yasuyuki
Published: October 2017

Biaryl diamines are important building blocks in organic ­synthesis. Consequently, it is desirable to develop a general and mild synthetic approach to diverse biaryl diamines. Oxidative coupling is an efficient and promising strategy for the synthesis of these targets. We have now developed a direct formation of biaryl diamines by oxidative coupling using a hypervalent iodine(III) reagent.
Lesbian Pregnancy: Care and Considerations
Authors: Bushe Sierra , Romero Iris
Published: October 2017

The constructs and the provision of preconception and obstetrical care have historically been based on the assumption of heterosexuality, and have often excluded lesbian women. However, due to significant strides in lesbian, gay, bisexual, transgender, and queer (LGBTQ) civil rights, more lesbian women desire to create and expand their families, and lesbian parented families are increasing. This places obstetrical care providers at the forefront of the movement to build inclusive health care environments. Therefore, it is incumbent upon those of us who work in obstetrics to understand, recognize, and respect the unique cultural considerations that pertain to lesbian women and couples seeking parenthood. This review seeks to provide culturally sensitive guidance on the specific concerns and challenges lesbians face, from preconception care to postpartum care, and briefly addresses legal issues and considerations for the nonbiologic mother. The recommendations outlined here are drawn from studies of the experiences of lesbian women with pregnancy. However, the scientific literature is very limited, and there is a clear need for additional obstetrical research focused on this patient group. As professionals committed to assuring optimal outcomes for all obstetrical patients, it is crucial that we promote the inclusion of sexual minority women in our clinical practices and research endeavors.
Vocal Symptoms and Associated Risk Factors between Male and Female University Teachers
Authors: Korn Gustavo , Park Sung , Pontes Antonio , Pontes Paulo
Published: October 2017

Introduction Many recent studies on teachers warn of the adverse effects that voice problems have on work performance. However, only a few of these studies included university teachers.

Objective To compare the vocal symptoms and risk factors between male and female university teachers in a private institution within the city of São Paulo.

Methods In a cross-sectional survey, a voice self-evaluation form prepared by the Ministry of Labor in Brazil was administered to 846 university teachers at a private institution in the city of São Paulo.

Results The percentage of hoarseness, vocal tract discomfort, neck pain and foreign body sensation was significantly higher in female than in male subjects. A significantly higher percentage of males participated in other professional activities in addition to teaching, reported working in a calm environment compared with working in a moderately or severely tense and stressful environment, and rated themselves as calm, slightly stressed and anxious or moderately stressed and anxious rather than very stressed and anxious. A significantly higher percentage of females spent most of their time teaching compared with performing other professional activities, and rated themselves as chatty or impulsive.

Conclusion Among university teachers, a significantly higher percentage of females than males reported hoarseness, vocal tract discomfort, neck pain and foreign body sensation. Some risk factors related to work organization, workplace environment, voice care and quality of life variables were related to this higher prevalence in females.
Preparing Future Health Professionals for Interprofessional Collaborative Practice Part 2: The Student Experience
Authors: Inzana Rebecca , Cahn Peter , Reidy Patricia , Knab Mary
Published: October 2017

Responding to increasing calls for change in systems of care delivery and revisions in the way health professionals are educated, academic programs across the health professions, including speech-language pathology, are placing increased emphasis on interprofessional collaborative practice and interprofessional education. This article provides a foundation for understanding these changes and what is driving them. Using an example from one academic program, it provides a view of the shifting student experience and discusses implications for speech-language pathologists serving as educators and supervisors in external placements. The article concludes with suggestions for integrating competencies for collaborative practice into one's clinical teaching and maximizing effectiveness in fostering student readiness for practice in the complex medical and education environments in which speech-language pathologists practice.
The Natural Growth Rate of Residual Juvenile Angiofibroma
Authors: Rowan Nicholas , Stapleton Amanda , Heft-Neal Molly , Gardner Paul , Snyderman Carl
Published: October 2017

Objectives Examine the postoperative growth rate of residual juvenile angiofibroma (JA) in a large series of patients relative to pediatric growth parameters and other prognostic factors. Establish an algorithm for postoperative surveillance of patients with JA.

Design Retrospective case series.

Setting Tertiary referral academic center.

Participants Pediatric patients undergoing surgical resection of JA between September 2005 and June 2015.

Main Outcome Measures Postoperative recurrence and tumor growth rates.

Results Thirty-eight patients were identified with a mean follow-up of 24.1 months. Sixty-eight percent (26/34) of patients achieved gross total resection, and 32% (12/38) had persistent postoperative disease. Of those with postoperative residual tumor, all had preoperative skull base involvement and residual blood supply from the internal carotid artery following embolization. Sixty-seven percent (8/12) of patients with postoperative residual tumor demonstrated radiographic stability of disease with scans being completed approximately every 6 months. Radiographic rates of disease progression ranged from 4.1 to 9.22 mm/year.

Conclusions Patients with preoperative skull base involvement and residual vascularity following preoperative embolization are more likely to have residual postoperative disease, and a longer postoperative follow-up is warranted in these patients. Progression of residual disease occurred approximately 7.5 months postoperatively. Younger patients may be more likely to need further intervention for postoperative residual disease, and postoperative imaging at 6-month intervals appears appropriate.
Open vs. Percutaneous Pedicle Screw Insertion for Thoracolumbar Traumatic A3 and A4 AO Fractures - 18-Months Follow-Up
Authors: Romero Flávio , Vieira Rodolfo , Ancheschi Bruno
Published: October 2017

Purpose To compare the efficacy and safety of the percutaneous screw fixation (PSF) and the open pedicle screw fixation (OPSF) on thoracolumbar (TL) fracture.

Methods Sixty-four adult patients with TL vertebral fractures who underwent open or percutaneous posterior short-segment transpedicular screw fixation between January of 2013 and September of 2015 were retrospectively reviewed. All patients underwent clinical, radiological and quality of life follow-up for at least 18 months.

Results There was no significant difference in age, gender, time between injury and surgery, and preoperative percentage of anterior column height, preoperative sagittal regional Cobb angle, or kyphotic angle of fractured vertebra between these two groups (p > 0.05). There was significantly less intraoperative blood loss in the PSF (87.6 ± 24.6 mL) than in the OPSF group (271.4 ± 142.6 mL) (p < 0.05). The mean surgery time was 62 minutes (range 42–130 minutes) for open and 58 minutes (range 35 to 128 minutes) for percutaneous screw fixation. The surgery time was shorter in the PSF group, but with no statistical significance (p > 0.05). The mean Oswestry disability index (ODI) scores after 18-months were 23.12 ± 8.2 for the PSF and 24.12 ± 9.2 for the OPSF group, without any statistical significance (p > 0.05).

Conclusion Both open and percutaneous screw fixations are safe and effective. The percutaneous techniques significantly reduced the intraoperative blood loss compared with the open techniques.
Nebenwirkungen von Psychopharmaka: Tipps für die Praxis
Authors: Grunze Anna , Mago Rajnish , Grunze Heinz
Published: October 2017

Psychotropics are highly effective medications that, however, have adverse drug reactions attached to them. They are indispensable for many patients. How to cope with side effects – watchful waiting, dose reduction, change of medication, addition of an “antidote” and behavioural modifications – depends on their nature, severity and finally the patients wish. This review is meant to aid clinician’s and patient’s decisions in case of the occurrence of compromising, frequent adverse drug reactions.
Fallpauschalenabbildung plastischer Rekonstruktionen bei malignen Hauttumoren im Kopf-Hals-Bereich
Authors: Lotter Oliver , Micheel Manuela , Jaminet Patrick
Published: October 2017

Hintergrund In Deutschland wurden vor nunmehr 13 Jahren Fallpauschalen als medizinisch-ökonomisches Klassifikationssystem eingeführt.
Im Folgenden soll die Abbildung plastischer Rekonstruktionen bei malignen Hauttumoren im Kopf-Hals-Bereich durch Diagnosis Related Groups
(DRG) analysiert werden.

Material und Methoden Vier verschiedene Hauptdiagnosen (Malignes Melanom, Basalzellkarzinom, Plattenepithelkarzinom, Carcinoma in
situ) an bis zu 6 unterschiedlichen Lokalisationen im Kopf-Hals-Bereich wurden mit folgenden Prozeduren kombiniert und mittels DRG-Grouper
untersucht: Exzision mit Primärnaht, Exzision mit temporärer Weichteildeckung, Plastische Deckung durch Eigenhaut, lokale, freie, gestielte
regionale Lappen und Fernlappenplastiken sowie Kombinationsdeckungen.

Ergebnisse Durch 5750 verschlüsselte Diagnose-Prozeduren-Kombinationen wurden 10 unterschiedliche DRGs bestimmt. Bei großflächigen
temporären Weichteildeckungen und Hauttransplantationen dominiert die DRG J22Z (Erlös 2817 €). In 2017 wurden die häufig durchgeführten
lokalen Lappenplastiken hiervon abgewertet und führen aktuell in die DRG J11D (Erlös 1903 €). In diesem Zusammenhang sind
Fallzusammenführungen durch ein zweizeitiges stationäres Vorgehen (Sitzung 1: Exzision, Sitzung 2: Plastische Deckung) von besonderer
Bedeutung. Malignome an der Lippe ergeben eine eher unruhige DRG-Abbildung ohne klar abzuleitende Gruppierungsregeln. Die hochbewertete
Basis-DRG J08 (DRGs J08A, J08B und J08C) kann nahezu ausnahmslos durch einzelne zusätzliche OPS-Ziffern erreicht werden.

Schlussfolgerung Die derzeitige Fallpauschalensituation für plastische Rekonstruktionen im Rahmen maligner Hauttumoren bietet etliche
potentielle Fehlanreize, welche Einfluss auf die Patientenversorgung haben können. Auf der Suche nach einem diversifizierten DRG-Portfolio
bietet sich die Basis-DRG J08 neben der gängigen Kodierpraxis mit entsprechenden Fallpauschalen an. Die Autoren sehen darin die Möglichkeit,
bei aktueller Abwertung auch ressourcenintensive Spezialfälle aufwandgerecht abzubilden. Vor einer unbegründeten und inflationären Anwendung
wird jedoch aufgrund einer fehlenden nachhaltigen Ausrichtung aufgrund von Verwässerung ausdrücklich gewarnt.
Magnifying image-enhanced endoscopy for collagenous colitis
Authors: Kobayashi Masaaki , Hoshi Takahiro , Morita Shin-ich , Kanefuji Tsutomu , Suda Takeshi , Hasegawa Go , Terai Shuji
Published: October 2017

Background and study aims We report a case series of 5 patients with collagenous colitis (CC) presenting with chronic watery diarrhea, who were subjected to magnifying, chromoendoscopy and narrow band imaging (NBI). Magnifying chromoendoscopy revealed whitish-clouded, honeycomb-like appearance at orifices of the crypts. NBI with high magnification revealed irregular caliber variation of the subepithelial capillary network. Presence of these features corresponded with histological characteristics of CC indicated by thickening of the subepithelial collagen layer. We concluded that magnifying image-enhanced endoscopy is a reliable tool to diagnose CC.
„Surgeon-modified“ Stentgrafts für den Notfall – Ergänzung zu „off-the-shelf“ Prothesen für die Versorgung von komplexen abdominellen und thorakoabdominellen Aortenpathologien
Authors: Heidemann Franziska , Kölbel Tilo , Debus Sebastian , Behrendt Christian-Alexander , Diener Holger , Rohlffs Fiona , Tsilimparis Nikolaos
Published: October 2017

Hintergrund Die endovaskulären Techniken haben die Therapie von Erkrankungen der abdominellen und thorakoabdominellen Aorta revolutioniert. Für die Versorgung im Bereich der infrarenalen Aorta ist die endovaskuläre Therapie mittlerweile ein Standardverfahren für Elektivfälle und im Notfall. Für komplexe, d. h. die renoviszeralen Gefäße einbeziehende, abdominelle und thorakoabdominelle Aortenpathologien bestehen sowohl offen als auch endovaskulär große technische Herausforderungen. Aufgrund der hohen Mortalität und Morbidität der offenen Chirurgie, insbesondere im Notfall, haben sich auch hier verschiedene endovaskuläre Techniken, insbesondere für Mittel- bis Hochrisikopatienten, zur Versorgung entwickelt.

Ergebnisse Zu den endovaskulären Therapieoptionen zählen grundsätzlich die fenestrierten und gebranchten Stentprothesen, die entsprechend der Anatomie runde Aussparungen („Fenestrierung“) oder Abzweigungen („Branches“) für die renoviszeralen Gefäße haben, sowie die Chimney-Graft-Technik. Im Elektivfall können patientenindividuelle fenestrierte und gebranchte Prothesen („custom-made“) bestellt werden. Planung, Produktion und Lieferung erfordern jedoch eine Wartezeit von bis zu 12 Wochen. Im dringlichen Fall steht aktuell nur eine 4-fach gebranchte und patientenunspezifische, d. h. „off-the-shelf“ („von der Stange“) Stentprothese zur Verfügung, die für nur schätzungsweise 60% der Patientenanatomien mit komplexem abdominellem und thorakoabdominellem Aortenaneurysma passt. Für Patienten ohne passende Anatomie stehen die sog. „surgeon-modified“ oder „vom Chirurgen modifizierten“ Stentprothesen als Alternative zur Verfügung. Hierbei wird eine kommerzielle Prothese direkt präoperativ mit den notwendigen Fenestrierungen modifiziert. Verglichen mit den „off-the-shelf“ Stentprothesen weist die Literatur aktuell für die „surgeon-modified“ Technik ähnliche Ergebnisse bez. Morbidität und Mortalität auf.

Schlussfolgerung Die „surgeon-modified“ Stentprothesen haben ihren Stellenwert bei Hochrisikopatienten mit symptomatischen und gedeckt rupturierten komplexen Aneurysmen. Bis kommerzielle fenestrierte und gebranchte Stentprothesen für alle anatomischen Gegebenheiten als „off-the-shelf“ Prothesen vorhanden sind, stellt die „surgeon-modified“ Technik eine gute Behandlungsoption dar.