bluuebunny/crossref_metadata_2025 huggingface dataset:
Peanut Shell Extract Improves Mitochondrial Function in db/db Mice via Suppression of Oxidative Stress and Inflammation
Authors: Deshmukh Hemalata , Santos Julianna M. , Bender Matthew , Dufour Jannette M. , Lovett Jacob , Shen Chwan-Li
Published: June 2024

Accumulating evidence shows a strong correlation between type 2 diabetes mellitus, mitochondrial dysfunction, and oxidative stress. We evaluated the effects of dietary peanut shell extract (PSE) supplementation on mitochondrial function and antioxidative stress/inflammation markers in diabetic mice. Fourteen db/db mice were randomly assigned to a diabetic group (DM in AIN-93G diet) and a PSE group (1% wt/wt PSE in AIN-93G diet) for 5 weeks. Six C57BL/6J mice were fed with an AIN-93G diet for 5 weeks (control group). Gene and protein expression in the liver, brain, and white adipose tissue (WAT) were determined using qRT-PCR and Immunoblot, respectively. Compared to the control group, the DM group had (i) increased gene and protein expression levels of DRP1 (fission), PINK1 (mitophagy), and TNFα (inflammation) and (ii) decreased gene and protein expression levels of MFN1, MFN2, OPA1 (fusion), TFAM, PGC-1α (biogenesis), NRF2 (antioxidative stress) and IBA1 (microglial activation) in the liver, brain, and WAT of db/db mice. Supplementation of PSE into the diet restored the DM-induced changes in the gene and protein expression of DRP1, PINK1, TNFα, MFN1, MFN2, OPA1, TFAM, PGC-1α, NRF2, and IBA1 in the liver, brain, and WAT of db/db mice. This study demonstrates that PSE supplementation improved mitochondrial function in the brain, liver, and WAT of db/db mice, in part due to suppression of oxidative stress and inflammation.
Association between Vitamin D Deficiency and Prediabetes Phenotypes: A Population-Based Study in Henan, China
Authors: Wang Guojie , Feng Shixian , Xu Jiying , Wei Xiaolin , Yang Guojun
Published: June 2024

The evidence remains inconsistent regarding whether vitamin D deficiency (VDD) increases the risk of prediabetes. This study aimed to examine whether there is sex-specific association between VDD and impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) in Henan. The data were sourced from the survey of chronic diseases and nutrition in Henan. Multinomial logistic regression models based on complex sampling design and weight were developed to estimate the odds ratio (OR) and confidence interval (95%CI) for measuring the association between VDD and IFG/IGT. The prevalence rate of IGT in men was 20.1% in the VDD group, significantly higher than that in the non-VDD group (10.5%), but no significant difference was observed in women between the VDD and non-VDD groups; there were no significant differences in IFG prevalence between the VDD and non-VDD groups in either men or women. It was found that the association between VDD and IGT was statistically significant in men. The adjusted OR (95%CI) of VDD was 1.99 (1.24–3.19) for IGT in men and 14.84 (4.14–53.20) for IGT in men having a family history of DM. Thus, men with VDD were more likely to live with IGT than those without VDD, especially for men having a family history of diabetes.
Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization
Authors: Hu Yiming , Yu Miao , Wang Yaqiang , Wu Haotian , Yang Xueqing , Chen Xiangxin , Wu Jing
Published: June 2024

Previous studies show that B vitamins and homocysteine (Hcy) may be associated with mental disorders, but the accurate causal relationship remains unclear. This study aimed to elucidate the potential causal relationship of serum B vitamins and Hcy levels with five common mental disorders through a two-sample Mendelian randomization (MR) study. In this MR analysis, 50 single-nucleotide polymorphisms (SNPs)—13 related to folate, 17 to vitamin B6, 8 to vitamin B12 and 12 to Hcy—were obtained from a large-scale Genome-Wide Association Studies (GWAS) database and employed as instrumental variables (IVs). The MR analyses were conducted using the inverse variance weighted (IVW), weighted median (WM), MR-Egger methods and sensitivity analyses were further performed to test the robustness. This MR study found a suggestive causal relationships between serum vitamin B12 levels and the risk of anxiety disorders (odds ratio (OR): 1.34, 95% confidence interval (CI): 1.01–1.78, p = 0.046) and bipolar affective disorders (OR: 1.85, 95% CI: 1.16–2.96, p = 0.010). However, folate, vitamin B6 and Hcy levels may not be causally associated with the risk of mental disorders. In conclusion, this study reveals that elevated serum vitamin B12 levels might suggestively increase the risk of anxiety and bipolar affective disorders, even though horizontal pleiotropy cannot be completely eliminated. The potential implications of our results warrant validation in larger GWAS based on diverse populations.
Perception of Complementary Medicine and Treatment Adherence as Predictors of Self-Efficacy in Individuals with Chronic Conditions in Mexico
Authors: Casco-Gallardo Karina Isabel , Torres-Soto Nissa Yaing , Orozco-González Claudia Nelly , Pérez-Briones Nancy Griselda , Guerrero-Solano José Antonio , Maldonado-Muñiz Gabriela , Trejo-García Claudia Atala , López-Nolasco Benjamín
Published: June 2024

Chronic diseases such as type 2 diabetes mellitus (T2DM), arterial hypertension (HTN), and obesity are significant global health challenges, contributing to millions of premature deaths. In Mexico, these pose major challenges due to limited access to healthcare and inadequate primary care quality. Complementary medicine presents itself as an adjuvant in this context, offering minimally invasive techniques to enhance physical, mental, and spiritual well-being. However, effective treatment adherence is crucial for positive outcomes, influenced by self-efficacy, resulting in persistently low adherence rates—a pressing public health concern. This observational study aimed to explore how perceptions of complementary medicine and treatment adherence predict self-efficacy among individuals with chronic diseases in Mexico. Data were collected from 113 participants with chronic conditions, including T2DM, HTN, and obesity. Participants completed surveys assessing perception of complementary medicine, treatment adherence, and self-efficacy. Statistical analyses, including correlations and regression, were conducted to examine the relationships between variables. The study revealed significant correlations between the perception of complementary medicine, treatment adherence, and self-efficacy. Treatment adherence was positively associated with self-efficacy, while perception of holistic medicine was negatively correlated with self-efficacy. Perception of complementary medicine and adherence to treatment were found to predict 41.9% (p = 0.001) self-efficacy. These findings underscore the potential of complementary therapies in enhancing self-efficacy levels, and highlight the importance of holistic healthcare approaches in managing chronic conditions. Further research is needed to better understand these relationships and their implications for healthcare outcomes in Mexico and beyond.
Does Phage Therapy Need a Pan-Phage?
Authors: Bozidis Petros , Markou Eleftheria , Gouni Athanasia , Gartzonika Konstantina
Published: June 2024

The emergence of multidrug-resistant bacteria is undoubtedly one of the most serious global health threats. One response to this threat that has been gaining momentum over the past decade is ‘phage therapy’. According to this, lytic bacteriophages are used for the treatment of bacterial infections, either alone or in combination with antimicrobial agents. However, to ensure the efficacy and broad applicability of phage therapy, several challenges must be overcome. These challenges encompass the development of methods and strategies for the host range manipulation and bypass of the resistance mechanisms developed by pathogenic bacteria, as has been the case since the advent of antibiotics. As our knowledge and understanding of the interactions between phages and their hosts evolves, the key issue is to define the host range for each application. In this article, we discuss the factors that affect host range and how this determines the classification of phages into different categories of action. For each host range group, recent representative examples are provided, together with suggestions on how the different groups can be used to combat certain types of bacterial infections. The available methodologies for host range expansion, either through sequential adaptation to a new pathogen or through genetic engineering techniques, are also reviewed.
Foreign Bodies in Pediatric Otorhinolaryngology: A Review
Authors: Paladin Ivan , Mizdrak Ivan , Gabelica Mirko , Golec Parčina Nikolina , Mimica Ivan , Batinović Franko
Published: June 2024

Foreign bodies (FBs) in pediatric otorhinolaryngology represent up to 10% of cases in emergency departments (ED) and are primarily present in children under five years old. They are probably the result of children’s curiosity and tendency to explore the environment. Aural and nasal FBs are the most common and accessible, and the removal methods differ depending on the exact location and type of FB, which can be organic or inorganic. A fish bone stuck in one of the palatine tonsils is the most common pharyngeal FB. Laryngopharyngeal FBs can obstruct the upper respiratory tract and thus become acutely life-threatening, requiring an urgent response. Aspiration of FBs is common in children between 1 and 4 years old. A history of coughing and choking is an indication of diagnostic and therapeutic methods to rule out or confirm a tracheobronchial FB. Regardless of the availability of radiological diagnostics, rigid bronchoscopy is the diagnostic and therapeutic method of choice in symptomatic cases. Radiological diagnostics are more significant in treating esophageal FBs since most are radiopaque. Flexible or rigid esophagoscopy is a successful method of removal. A delayed diagnosis, as with tracheobronchial FBs, can lead to fatal consequences.
The Psychosocial Impact of the COVID-19 Pandemic on Italian Families: The Perception of Quality of Life and Screening of Psychological Symptoms
Authors: Incardona Roberta Maria , Tremolada Marta
Published: June 2024

Throughout the COVID-19 period, families were forced to stay indoors, adapting to online schooling, remote work, and virtual social engagements, inevitably altering the dynamics within households. There was a notable increase in mental health challenges in terms of anxiety and depression in children and adolescents. This study intended to explore the psychosocial effects of the COVID-19 pandemic on Italian families by adopting self- and proxy-report questionnaires on anxiety, anger, and health-related quality of life. The results showed that approximately 20% obtained a clinical anxiety score and only 10% obtained a clinical anger score. There was a difference in the perception of the quality of life reported by the child and that perceived by the parent. A stepwise regression model showed that total anxiety scores were predicted by sex, quality of life scores from the parents’ self-report version, and the total anger score. Another stepwise regression model identified physiological and social anxiety as the best predictors that impact quality of life. Parental well-being actively influences the well-being of children, so it is fundamental to implement preventive programs and promote child well-being by providing parents the most adequate support possible.
Respiratory Symptoms among Adolescents in Poland: A Study on Cigarette Smokers, E-Cigarette Users, and Dual Users
Authors: Kurdyś-Bykowska Paulina , Kośmider Leon , Konwant Dawid , Stencel-Gabriel Krystyna
Published: June 2024

In recent years, the prevalence of tobacco and electronic cigarette (e-cigarette) use among adolescents has raised significant public health concerns worldwide. This study aimed to investigate respiratory symptoms among Polish adolescents. We conducted an online survey among Polish school students from all provinces, collecting data over two months in spring 2021. Students voluntarily complete the anonymous survey, answering questions about respiratory symptoms, smoking habits (both traditional and electronic cigarettes), and demographic information. The analysis focused on four subgroups, namely non-tobacco users, traditional cigarette smokers, e-cigarette users, and dual users, totaling 10,388 pupils aged 12–18 years, predominantly attending secondary technical and comprehensive schools. A total of 10,388 pupils participated in the study, 55.6% (5778) of whom were girls and 44.4% (4610) boys. Adolescents who admitted using both e-cigarettes and traditional cigarettes experienced more frequent episodes of cough during the day (39.70%) and at night (18.40%) compared to their peers in other groups. Chest discomfort, including pain and pressure, was also reported more often by adolescents who used e-cigarettes and traditional cigarettes concurrently (27.60%) compared to their peers in other groups. Chest pressure was experienced less commonly by non-smoking adolescents (14.40%) than by smokers (18.90%). Higher severity of cough during the day and at night was observed in the group of adolescents using traditional cigarettes and e-cigarettes concurrently compared to the other groups. The adolescents in the dual-user group experienced more severe dyspnea and wheezing compared to the other groups included in the comparison. The results of this study confirm the correlation between the occurrence of respiratory symptoms in adolescents who smoke cigarettes, adolescents who use e-cigarettes, and adolescents who are dual users. The respiratory symptoms occur most frequently and are the most severe in the group of adolescents who use e-cigarettes and traditional cigarettes
Iron-Based Metal-Organic Frameworks as Multiple Cascade Synergistic Therapeutic Effect Nano-Drug Delivery Systems for Effective Tumor Elimination
Authors: Zheng Heming , An Guanghui , Yang Xiaohui , Huang Lei , Wang Nannan , Zhu Yanqiu
Published: June 2024

Efforts have been made to improve the therapeutic efficiency of tumor treatments, and metal-organic frameworks (MOFs) have shown excellent potential in tumor therapy. Monotherapy for the treatment of tumors has limited effects due to the limitation of response conditions and inevitable multidrug resistance, which seriously affect the clinical therapeutic effect. In this study, we chose to construct a multiple cascade synergistic tumor drug delivery system MIL−101(Fe)−DOX−TCPP−MnO2@PDA−Ag (MDTM@P−Ag) using MOFs as drug carriers. Under near-infrared (NIR) laser irradiation, 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and Ag NPs loaded on MDTM@P−Ag can be activated to generate cytotoxic reactive oxygen species (ROS) and achieve photothermal conversion, thus effectively inducing the apoptosis of tumor cells and achieving a combined photodynamic/photothermal therapy. Once released at the tumor site, manganese dioxide (MnO2) can catalyze the decomposition of hydrogen peroxide (H2O2) in the acidic microenvironment of the tumor to generate oxygen (O2) and alleviate the hypoxic environment of the tumor. Fe3+/Mn2+ will mediate a Fenton/Fenton-like reaction to generate cytotoxic hydroxyl radicals (·OH), while depleting the high concentration of glutathione (GSH) in the tumor, thus enhancing the chemodynamic therapeutic effect. The successful preparation of the tumor drug delivery system and its good synergistic chemodynamic/photodynamic/photothermal therapeutic effect in tumor treatment can be demonstrated by the experimental results of material characterization, performance testing and in vitro experiments.
Cannabinoids: Potential for Modulation and Enhancement When Combined with Vitamin B12 in Case of Neurodegenerative Disorders
Authors: Kaszyńska Anna Aleksandra
Published: June 2024

The enduring relationship between humanity and the cannabis plant has witnessed significant transformations, particularly with the widespread legalization of medical cannabis. This has led to the recognition of diverse pharmacological formulations of medical cannabis, containing 545 identified natural compounds, including 144 phytocannabinoids like Δ9-THC and CBD. Cannabinoids exert distinct regulatory effects on physiological processes, prompting their investigation in neurodegenerative diseases. Recent research highlights their potential in modulating protein aggregation and mitochondrial dysfunction, crucial factors in conditions such as Alzheimer’s Disease, multiple sclerosis, or Parkinson’s disease. The discussion emphasizes the importance of maintaining homeodynamics in neurodegenerative disorders and explores innovative therapeutic approaches such as nanoparticles and RNA aptamers. Moreover, cannabinoids, particularly CBD, demonstrate anti-inflammatory effects through the modulation of microglial activity, offering multifaceted neuroprotection including mitigating aggregation. Additionally, the potential integration of cannabinoids with vitamin B12 presents a holistic framework for addressing neurodegeneration, considering their roles in homeodynamics and nervous system functioning including the hippocampal neurogenesis. The potential synergistic therapeutic benefits of combining CBD with vitamin B12 underscore a promising avenue for advancing treatment strategies in neurodegenerative diseases. However, further research is imperative to fully elucidate their effects and potential applications, emphasizing the dynamic nature of this field and its potential to reshape neurodegenerative disease treatment paradigms.
Critical Appraisal and Future Challenges of Artificial Intelligence and Anticancer Drug Development
Authors: Chamorey Emmanuel , Gal Jocelyn , Mograbi Baharia , Milano Gérard
Published: June 2024

The conventional rules for anti-cancer drug development are no longer sufficient given the relatively limited number of patients available for therapeutic trials. It is thus a real challenge to better design trials in the context of new drug approval for anti-cancer treatment. Artificial intelligence (AI)-based in silico trials can incorporate far fewer but more informative patients and could be conducted faster and at a lower cost. AI can be integrated into in silico clinical trials to improve data analysis, modeling and simulation, personalized medicine approaches, trial design optimization, and virtual patient generation. Health authorities are encouraged to thoroughly review the rules for setting up clinical trials, incorporating AI and in silico methodology once they have been appropriately validated. This article also aims to highlight the limits and challenges related to AI and machine learning.
Chemopreventive Potential of Phyllanthus emblica Fruit Extract against Colon and Liver Cancer Using a Dual-Organ Rat Carcinogenesis Model
Authors: Singai Chonikarn , Pitchakarn Pornsiri , Taya Sirinya , Phannasorn Warunyoo , Wongpoomchai Rawiwan , Wongnoppavich Ariyaphong
Published: June 2024

Humans are frequently exposed to various carcinogens capable of inducing cancer in multiple organs. Phyllanthus emblica (P. emblica) is known for its strong antioxidant properties and potential in cancer prevention. However, its effectiveness against combined carcinogens remains relatively unexplored. This study aimed to assess the chemopreventive potential of the ethanolic extract of P. emblica fruits against preneoplastic lesions in the liver and colon using a rat model. Rats were administered with diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) to induce hepato- and colon carcinogenesis, respectively. The ethanolic extract of P. emblica fruit at 100 and 500 mg/kg bw significantly reduced the number of preneoplastic lesions in the liver by 74.7% and 55.6%, respectively, and in the colon by 39.2% and 40.8%, respectively. Similarly, the extract decreased the size of preneoplastic lesions in the liver by 75.2% (100 mg/kg bw) and 70.6% (500 mg/kg bw). Furthermore, the extract significantly reduced the cell proliferation marker in the liver by 70.3% (100 mg/kg bw) and 61.54% (500 mg/kg bw), and in the colon by 62.7% (100 mg/kg bw) and 60.5% (500 mg/kg bw). The ethanolic extract also enhanced liver antioxidant enzyme activities and demonstrated free radical scavenging in DPPH, ABTS, and FRAP assays. Additionally, the dichloromethane fraction of P. emblica showed significant cancer prevention potential by reducing intracellular ROS and NO production by 61.7% and 35.4%, respectively, in RAW 264.7 macrophages. It also exhibited antimutagenic effects with a reduction of 54.0% against aflatoxin B1 and 52.3% against 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mutagenesis in Salmonella typhimurium. Finally, this study highlights the chemopreventive activity of P. emblica fruit extract against the initiation of early-stage carcinogenic lesions in the liver and colon in rats treated with dual carcinogens.
Pharmaceutical Potential of Remedial Plants and Helminths for Treating Inflammatory Bowel Disease
Authors: Jamtsho Tenzin , Loukas Alex , Wangchuk Phurpa
Published: June 2024

Research is increasingly revealing that inflammation significantly contributes to various diseases, particularly inflammatory bowel disease (IBD). IBD is a major medical challenge due to its chronic nature, affecting at least one in a thousand individuals in many Western countries, with rising incidence in developing nations. Historically, indigenous people have used natural products to treat ailments, including IBD. Ethnobotanically guided studies have shown that plant-derived extracts and compounds effectively modulate immune responses and reduce inflammation. Similarly, helminths and their products offer unique mechanisms to modulate host immunity and alleviate inflammatory responses. This review explored the pharmaceutical potential of Aboriginal remedial plants and helminths for treating IBD, emphasizing recent advances in discovering anti-inflammatory small-molecule drug leads. The literature from Scopus, MEDLINE Ovid, PubMed, Google Scholar, and Web of Science was retrieved using keywords such as natural product, small molecule, cytokines, remedial plants, and helminths. This review identified 55 important Aboriginal medicinal plants and 9 helminth species that have been studied for their anti-inflammatory properties using animal models and in vitro cell assays. For example, curcumin, berberine, and triptolide, which have been isolated from plants; and the excretory-secretory products and their protein, which have been collected from helminths, have demonstrated anti-inflammatory activity with lower toxicity and fewer side effects. High-throughput screening, molecular docking, artificial intelligence, and machine learning have been engaged in compound identification, while clustered regularly interspaced short palindromic repeats (CRISPR) gene editing and RNA sequencing have been employed to understand molecular interactions and regulations. While there is potential for pharmaceutical application of Aboriginal medicinal plants and gastrointestinal parasites in treating IBD, there is an urgent need to qualify these plant and helminth therapies through reproducible clinical and mechanistic studies.
64Cu2+ Complexes of Tripodal Amine Ligands’ In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study
Authors: Shinada Mitsuhiro , Takahashi Masashi , Igarashi Chika , Matsumoto Hiroki , Hihara Fukiko , Tachibana Tomoko , Oikawa Masakazu , Suzuki Hisashi , Zhang Ming-Rong , Higashi Tatsuya , Kurihara Hiroaki , Yoshii Yukie , Doi Yoshihiro
Published: June 2024

Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ is an anticancer radiopharmaceutical that targets the copper requirement of cancer cells. However, intravenously injected 64Cu2+ ions primarily accumulate in the liver. Ligand complexation of 64Cu2+ may be a promising method for increasing tumor delivery by reducing liver uptake. In this study, we used three tripodal amine ligands [tris(2-aminoethyl)amine (Tren), diethylenetriamine (Dien), and tris(2-pyridylmethyl)amine (TPMA)] to enclose 64Cu2+ ions and compared their in vivo tumor and liver uptakes using a tumor-bearing xenograft mouse model of the extrahepatic bile duct carcinoma cell line TFK-1. We examined intracellular Cu distribution using microparticle-induced X-ray emission (micro-PIXE) analysis of these compounds. 64Cu2+-Tren and 64Cu2+-Dien showed higher tumor uptake than 64Cu2+-TPMA and 64Cu2+ ions in TFK-1 tumors. Among the three 64Cu2+ complexes and 64Cu2+ ions, liver uptake was inversely correlated with tumor uptake. Micro-PIXE analysis showed that in vitro cellular uptake was similar to in vivo tumor uptake, and nuclear delivery was the highest for 64Cu2+-Tren. Conclusively, an inverse correlation between tumor and liver uptake was observed using three 64Cu2+ complexes of tripodal amine ligands and 64Cu2+ ions. These results provide useful information for the future development of anticancer 64Cu radiopharmaceuticals.
In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar–Zinc Phthalocyanine Conjugates
Authors: Makuch Sebastian , Kupczyk Piotr , Woźniak Marta , Makarec Alicja , Lipińska Maja , Klyta Magdalena , Sulecka-Zadka Joanna , Szeja Wiesław , Gani Mariachiara , Rapozzi Valentina , Ziółkowski Piotr , Smoleński Piotr
Published: June 2024

Psoriasis, a chronic immune-mediated skin disorder affecting over 125 million people globally, is characterized by abnormal keratinocyte proliferation and immune cell infiltration. Photodynamic therapy (PDT) remains underutilized in the treatment of psoriasis despite its potential as a promising and effective therapeutic approach. This study aimed to explore the efficacy of zinc phthalocyanine (ZnPc) and its sugar conjugates as potential antipsoriatic agents. We successfully synthesized protected and unprotected sugar-conjugated zinc phthalocyanines and evaluated their potential against cytokine-stimulated HaCaT keratinocytes, as well as an established IMQ psoriasis-like in vivo model. Tetrasubstituted protected glucose–ZnPc (Glu-4-ZnPc-P) demonstrated superior phototoxicity (IC50 = 2.55 µM) compared to unprotected glucose conjugate (IC50 = 22.7 µM), protected galactose–ZnPc (IC50 = 7.13 µM), and free ZnPc in cytokine-stimulated HaCaT cells (IC50 = 5.84 µM). Cellular uptake analysis revealed that IL-17A, a cytokine that plays a central role in the pathogenesis of psoriasis, enhanced unprotected Glu-4-ZnPc uptake by 56.3%, while GLUT1 inhibitor BAY-876 reduced its accumulation by 23.8%. Intracellular ROS generation following Glu-4-ZnPc-P-PDT was significantly increased after stimulation with IL-17A, correlating with in vitro photocytotoxicity. In vivo PDT using Glu-4-ZnPc-P exhibited significant improvement in Psoriasis Area and Severity Index (PASI), inhibiting splenomegaly and restoring normal skin morphology. This study highlights sugar-conjugated zinc phthalocyanines as potential candidates for targeted PDT in psoriasis, providing a basis for further clinical investigations.
Dancing in God in an Accelerating Secular World: Resonating with Kierkegaard’s Critical Philosophical Theology
Authors: Thompson Curtis L.
Published: June 2024

This essay seeks to scrutinize Kierkegaard’s critical philosophical theology. The intent is to demonstrate how his religious thought, especially on God’s relation to the world and to the human being, can contribute to generating a cogent response to the challenges presented by our accelerating secular world. Apart from the narrative on the Dane’s passionate reflections, I employ two other narratives to facilitate this inquiry into Kierkegaard. The first of these facilitating narratives comes from highlighting the work on the concept of resonance by the social theorist Hartmut Rosa. Rosa’s rich analysis of our contemporary situation provides a persuasive case for the accelerating pace of our secular world, the complex dynamics of alienation that are at play within it, and the need for social transformation that creates space for increasing resonance within personal and social relationships and structures. The second facilitating narrative centers on the notion of dancing in God, which I believe holds promise for effectively communicating moving, bodily, rhythmic, passionate, and responsive thoughts and actions concerning God’s engagement in our contemporary world. I hope to show that these three complementary discourses together provide a provocative religious discourse and vision that can prove helpful in addressing many of the challenges of our time.
Dressing the Lorentz Atom
Authors: Barnett Stephen M. , Cresser James D. , Croke Sarah
Published: June 2024

We investigate the effects of the electromagnetic vacuum field on a harmonically bound electron. We show that in the electric-dipole approximation the model atom couples only to an effective one-dimensional electric field. In a simplified form, in which the problem is reduced to a single spatial dimension, we determine, analytically, the form of the ground state and discuss the significance of this state.
Increasing Hybrid Rice Yield, Water Productivity, and Nitrogen Use Efficiency: Optimization Strategies for Irrigation and Fertilizer Management
Authors: Zhu Haijun , He Xiaoe , Wang Xuehua , Long Pan
Published: June 2024

Water and fertilizer are crucial in rice growth, with irrigation and fertilizer management exhibiting synergies. In a two-year field study conducted in Yiyang City, Hunan Province, we examined the impact of three irrigation strategies—wet-shallow irrigation (W1), flooding irrigation (W2), and the “thin, shallow, wet, dry irrigation” method (W3)—in combination with distinct fertilizer treatments (labeled F1, F2, F3, and F4, with nitrogen application rates of 0, 180, 225, and 270 kg ha−1, respectively) on rice yield generation and water–fertilizer utilization patterns. The study employed Hybrid Rice Xin Xiang Liang you 1751 (XXLY1751) and Yue Liang you Mei Xiang Xin Zhan (YLYMXXZ) as representative rice cultivars. Key findings from the research include water, fertilizer, variety, and year treatments, which all significantly influenced the yield components of rice. Compared to W2, W1 in 2022 reduced the amount of irrigation water by 35.2%, resulting in a 42.0~42.8% increase in irrigation water productivity and a 25.7~25.9% increase in total water productivity. In 2023, similar improvements were seen. Specifically, compared with other treatments, the W1F3 treatment increased nitrogen uptake and harvest index by 1.4–7.7% and 5.9–7.7%, respectively. Phosphorus and potassium uptake also improved. The W1 treatment enhanced the uptake, accumulation, and translocation of nitrogen, phosphorus, and potassium nutrients throughout the rice growth cycle, increasing nutrient levels in the grains. When paired with the F3 fertilization approach, W1 treatment boosted yields and improved nutrient use efficiency. Consequently, combining W1 and F3 treatment emerged as this study’s optimal water–fertilizer management approach. By harnessing the combined effects of water and fertilizer management, we can ensure efficient resource utilization and maximize the productive potential of rice.
Fine-Tuning of Arabidopsis thaliana Response to Endophytic Colonization by Gluconacetobacter diazotrophicus PAL5 Revealed by Transcriptomic Analysis
Authors: Soares Fabiano Silva , Rangel de Souza Ana Lídia Soares , de Souza Suzane Ariádina , de Souza Vespoli Luciano , Pinto Vitor Batista , Matiello Lucia , da Silva Felipe Rodrigues , Menossi Marcelo , de Souza Filho Gonçalo Apolinário
Published: June 2024

Gluconacetobacter diazotrophicus is a diazotrophic endophytic bacterium that promotes the growth and development of several plant species. However, the molecular mechanisms activated during plant response to this bacterium remain unclear. Here, we used the RNA-seq approach to understand better the effect of G. diazotrophicus PAL5 on the transcriptome of shoot and root tissues of Arabidopsis thaliana. G. diazotrophicus colonized A. thaliana roots and promoted growth, increasing leaf area and biomass. The transcriptomic analysis revealed several differentially expressed genes (DEGs) between inoculated and non-inoculated plants in the shoot and root tissues. A higher number of DEGs were up-regulated in roots compared to shoots. Genes up-regulated in both shoot and root tissues were associated with nitrogen metabolism, production of glucosinolates and flavonoids, receptor kinases, and transcription factors. In contrast, the main groups of down-regulated genes were associated with pathogenesis-related proteins and heat-shock proteins in both shoot and root tissues. Genes encoding enzymes involved in cell wall biogenesis and modification were down-regulated in shoots and up-regulated in roots. In contrast, genes associated with ROS detoxification were up-regulated in shoots and down-regulated in roots. These results highlight the fine-tuning of the transcriptional regulation of A. thaliana in response to colonization by G. diazotrophicus PAL5.
The Impact of ZnO and Fe2O3 Nanoparticles on Sunflower Seed Germination, Phenolic Content and Antiglycation Potential
Authors: Al-Sudani Waleed Khaled Kaddem , Al-Shammari Rawaa Shakir Shnain , Abed Mohammed Saheb , Al-Saedi Jasim Hafedh , Mernea Maria , Lungu Iulia Ioana , Dumitrache Florian , Mihailescu Dan Florin
Published: June 2024

The enhancement of seed germination by using nanoparticles (NPs) holds the potential to elicit the synthesis of more desired compounds with important biomedical applications, such as preventing protein glycation, which occurs in diabetes. Here, we used 7 nm and 100 nm ZnO and 4.5 nm and 16.7 nm Fe2O3 NPs to treat sunflower seeds. We evaluated the effects on germination, total phenolic content, and the anti-glycation potential of extracted polyphenols. Sunflower seeds were allowed to germinate in vitro after soaking in NP solutions of different concentrations. Polyphenols were extracted, dosed, and used in serum albumin glycation experiments. The germination speed of seeds was significantly increased by the 100 nm ZnO NPs and significantly decreased by the 4.5 nm Fe2O3 NPs. The total phenolic content (TPC) of seeds was influenced by the type of NP, as ZnO NPs enhanced TPC, and the size of the NPs, as smaller NPs led to improved parameters. The polyphenols extracted from seeds inhibited protein glycation, especially those extracted from seeds treated with 7 nm ZnO. The usage of NPs impacted the germination speed and total polyphenol content of sunflower seeds, highlighting the importance of NP type and size in the germination process.
The Development of Biocomposite Filaments for 3D Printing by Utilizing a Polylactic Acid (PLA) Polymer Matrix Reinforced with Cocoa Husk Cellulose Fibers
Authors: Almeida Victor Hugo Martins de , Jesus Raildo Mota de , Santana Gregório Mateus , Khan Sabir , Silva Erickson Fabiano Moura Sousa , Cruz Iago Silva da , Santos Ian de Souza , dos Anjos Paulo Neilson Marques
Published: June 2024

Vegetable fibers are increasingly used in biocomposites, but there is a need for further development in utilizing by-products like cocoa husks. Three-dimensional printing, through Fused Filament Fabrication (FFF), is advancing rapidly and may be of great interest for applying biocomposite materials. This study focuses on developing innovative and fully biodegradable filaments for the FFF process. PLA filaments were prepared using cellulose fibers derived from cocoa husks (5% mass ratio). One set of filaments incorporated fibers from untreated husks (UCFFs), while another set utilized fibers from chemically treated husks (TCFFs). The fabricated materials were analyzed using scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and Fourier transform infrared (FTIR) techniques, and they were also tested for tensile strength. ANOVA reveals that both UCFFs and TCFFs significantly predict tensile strength, with the UCFFs demonstrating an impressive R2 value of 0.9981. The optimal tensile strength for the filament test specimens was 16.05 MPa for TCFF8 and 13.58 MPa for UCFF8, utilizing the same printing parameters: 70% infill and a layer thickness of 0.10 mm. Additionally, there was an 18% improvement in the tensile strength of the printed specimens using the filaments filled with chemically treated cocoa husk fibers compared to the filaments with untreated fibers.
Improving Water Stability of Soil Aggregates with Polyvinyl Alcohol as a Polymeric Binder
Authors: Cao Chunyan , Cai Minkun , Zhao Lingyu , Li Gang
Published: June 2024

Soil degradation threatens agricultural productivity and food supply, leading to hunger issues in some developing regions. To address this challenge, we developed a low-cost, highly efficient, and long-term stable soil improvement method. We chose polyvinyl alcohol (PVA), a commercially available polymer that is safe and non-degradable, to serve as a soil adhesive. We mixed PVA solution into the soil and applied a drying treatment to enhance the bonding between PVA and the soil, achieving highly water-stable soil. This PVA-stabilized soil exhibits low bulk density, high porosity, and high permeability, making it an ideal substrate for planting. In a germination test, the PVA-stabilized soil revealed a higher germination rate and growth rate compared to those of the non-treated soil. We believe this simple and efficient soil improvement method can restore degraded soil and contribute to sustainable agriculture.
Preparation of a Highly Flame-Retardant Urea–Formaldehyde Resin and Flame Retardance Mechanism
Authors: Wei An , Ou Meifeng , Wang Shunxiang , Zou Yongjin , Xiang Cuili , Xu Fen , Sun Lixian
Published: June 2024

Urea–formaldehyde (UF) resin is the most widely used adhesive resin. However, it is necessary to improve its flame-retardant performance to expand its applications. In this study, exploiting electrostatic interactions, anionic phytic acid and cationic chitosan were combined to form a bio-based intumescent flame-retardant, denoted phytic acid–chitosan polyelectrolyte (PCS). The molecular structure of the urea–formaldehyde resin was optimized by crosslinking with melamine and plasticizing with polyvinyl alcohol-124. Thus, by combining PCS with the urea–formaldehyde resin and with ammonium polyphosphate and ammonium chloride as composite curing agents, flame-retardant urea–formaldehyde resins (FRUFs) were prepared. Compared to traditional UF resin, FRUF showed excellent flame retardancy and not only reached the UL-94 V-0 level, but the limit of oxygen index was also as high as 36%. Compared to those of UF, the total heat release and peak heat release rate of FRUF decreased by 86.44% and 81.13%, respectively. The high flame retardancy of FRUF originates from the combination of oxygen and heat isolation by the dense carbon layer, quenching of phosphorus free radicals, and dilution of oxygen by a non-flammable gas. In addition, the mechanical properties of the FRUF remained good, even after modification. The findings of this study provide a reference for the flame-retardant application of FRUF for applications in multiple fields.
Composite Ionogel Electrodes for Polymeric Solid-State Li-Ion Batteries
Authors: Schorr Noah B. , Bhandarkar Austin , McBrayer Josefine D. , Talin A. Alec
Published: June 2024

Realizing rechargeable cells with practical energy and power density requires electrodes with high active material loading, a remaining challenge for solid-state batteries. Here, we present a new strategy based on ionogel-derived solid-state electrolytes (SSEs) to form composite electrodes that enable high active material loading (>10 mg/cm2, ~9 mA/cm2 at 1C) in a scalable approach for fabricating Li-ion cells. By tuning the precursor and active materials composition incorporated into the composite lithium titanate electrodes, we achieve near-theoretical capacity utilization at C/5 rates and cells capable of stable cycling at 5.85 mA/cm2 (11.70 A/g) with over 99% average Coulombic efficiency at room temperature. Finally, we demonstrate a complete polymeric solid-state cell with a composite anode and a composite lithium iron phosphate cathode with ionogel SSEs, which is capable of stable cycling at a 1C rate.
Partially Bio-Based Benzoxazine Monomers Derived from Thymol: Photoluminescent Properties, Polymerization Characteristics, Hydrophobic Coating Investigations, and Anticorrosion Studies
Authors: Suesuwan Arunthip , Suetrong Natapol , Yaemphutchong Sila , Tiewlamsam Inthikan , Chansaenpak Kantapat , Wannapaiboon Suttipong , Chuanopparat Nutthawat , Srathongsian Ladda , Kanjanaboos Pongsakorn , Chanthaset Nalinthip , Wattanathana Worawat
Published: June 2024

In this work, four thymol-based benzoxazines were synthesized using four primary amines with different chain lengths, namely methylamine, ethylamine, 1-propylamine, and 1-butylamine, which are then named T-m, T-e, T-p, and T-b, respectively. The optical properties of the synthesized thymol-based benzoxazines were examined via the photoluminescent study of their solutions in acetone. The results show that all the prepared benzoxazines emitted blue light with the maximum wavelengths from 425 to 450 nm when irradiated by the excitation wavelengths from 275 to 315 nm. The maximum excitation wavelengths are found to be 275 nm. The polymerization of the thymol-based benzoxazines is triggered by heat treatments with different conditions (160, 180, and 200 °C for 1 h). According to the FTIR results, the heat-curing process introduces a presence of the OH peak, of which intensity increases as the curing temperature increases. Thermal decompositions of thymol-based benzoxazines regarding TGA analyses reveal the enhancement of thermal stability of the benzoxazines with respect to the N-substituent chain length, as significantly observed the change in the first thermal decomposition at temperature ranged from 253 to 260 °C. Synthesized benzoxazine derivatives are further employed to coat the substrate, e.g., the glass slides. The investigation of the water contact angle shows that the coating of the benzoxazines onto the surface improves the hydrophobicity of the substrate, resulting in the enlargement of the contact angle from 25.5° to 93.3°. Moreover, the anticorrosion performance of the polybenzoxazine coatings is examined using potentiodynamic polarization techniques. The results illustrate the anticorrosion efficiency of the thymol-based polybenzoxazine up to 99.99%. Both hydrophobic and electrochemical studies suggest the feasibility for employing benzoxazines in anticorrosion coating applications.
“Kierkegaard, Virtues and Vices”: Editorial Introduction
Authors: Lippitt John , Evans C. Stephen
Published: June 2024

In recent years, scholars have been divided on what to make of Kierkegaard’s relation to what some have called the virtues tradition [...]
The Relationship of the Religious Faith and Practice of Student Youth and Adults in Southeastern Poland and Western Ukraine with Their Health Status and Attitudes toward Physical Culture
Authors: Cynarski Wojciech J. , Dyndał Stanisław , Wąsik Jacek , Mosler Dariusz , Pavlova Iuliia , Yu Jong-Hoon , Ambroży Tadeusz , Kasicki Krzysztof , Rydzik Łukasz
Published: June 2024

Background: Religious faith and practice are important aspects of human life and give meaning to human existence. The development of modernity and consumerism has significantly undermined the religious foundations of a present-day global society. The aim of this study is to determine the relationships of the religious faith and practice of student youth and adults in Poland (Podkarpacie and Lesser Poland regions) and in western Ukraine (Lviv region) with their self-rated health status and attitudes toward physical culture. Methods: The study was conducted online in Poland and Ukraine from January to April 2022. A convenience sample of 1458 people was recruited. The questionnaire included 16 questions about religiosity, attitudes towards physical culture, and self-rated health status. Questions regarding self-esteem and attitudes towards physical culture were assessed on a Likert scale of 1 to 5 points. Other questions contained single-choice answers. Data were analyzed using Statistica v. 13.3. Results: The component of health that was rated highest was physical health among believers and mental health among non-believers. The results of the analysis of variance showed significant differences between the individual variables depending on the declaration of faith in God. Conclusion: While the faith of the inhabitants of southeastern Poland and western Ukraine is largely related to their regular religious practice, irregularity dominates this practice. Respondents combined ratings of their faith and/or practice with self-rated health status; more religious people had statistically lower levels of self-rated health.
Adaptive Background Endmember Extraction for Hyperspectral Subpixel Object Detection
Authors: Yang Lifeng , Song Xiaorui , Bai Bin , Chen Zhuo
Published: June 2024

Subpixel object detection presents a significant challenge within the domain of hyperspectral image (HSI) processing, primarily due to the inherently limited spatial resolution of imaging spectrometers. For subpixel object detection, the dimensional extent of the object of interest is smaller than an individual pixel, which significantly diminishes the utility of spatial information pertaining to the object. Therefore, the efficacy of detection algorithms depends heavily on the spectral data inherent in the image. The detection of subpixel objects in hyperspectral imagery primarily relies on the suppression of the background and the enhancement of the object of interest. Hence, acquiring accurate background information from HSI images is a crucial step. In this study, an adaptive background endmember extraction for hyperspectral subpixel object detection is proposed. An adaptive scale constraint is incorporated into the background spectral endmember learning process to improve the adaptability of background endmember extraction, thus further enhancing the algorithm’s generalizability and applicability in diverse analytical scenarios. Experimental results demonstrate that the adaptive endmember extraction-based subpixel object detection algorithm consistently outperforms existing state-of-the-art algorithms in terms of detection efficacy on both simulated and real-world datasets.
Remote Sensing of the Interaction between Human and Natural Ecosystems in Asia
Authors: Xue Bing , Xu Yaotian , Yang Jun
Published: June 2024

Human and natural ecosystems refer to human–social–economic subsystems and natural–ecological subsystems and their interactions. Understanding the interactions between human and natural ecosystems is essential for regional sustainability. However, the coupled human–nature ecosystem is usually highly heterogeneous and both spatially and temporally complex, so it is difficult to accurately identify and quantify the interaction between human and natural ecosystems at a large scale. This results in a poor understanding and evaluation of its impact on regional sustainability. Therefore, given the increasing interaction between humans and the natural ecosystem, our Special Issue collated 11 contributions from Asian scholars focusing on the latest research advances in remote sensing technologies and their application to observing, understanding, modeling, and explaining the interaction between human and natural ecosystems. This research involves the development of innovative methods, indicators, and frameworks implementing different perspectives and spatio-temporal scales, covering urban, arid, plateau, watershed, and marine regions in Asia and promoting the sustainable development of regional human and natural ecosystems.