bluuebunny/crossref_metadata_2025 huggingface dataset:
SÍNTESE, CARACTERIZAÇÃO E ESTUDO DOS PARÂMETROS DE JUDD-OFELT DE COMPOSTOS β-DICETONATOS DE Eu(III) OU Sm(III)
Authors: Scapolan Maria , Oliveira Daniel , Monteiro Jorge , Davolos Marian , Adati Renata
Published: July 2021

SYNTHESIS, CHARACTERIZATION AND JUDD-OFELT ANALYSIS OF Eu(III) OR Sm(III) β-DIKETONATE COMPLEXES. The lanthanide complexes [Ln(bmdm)3(L)] where Ln(III) = Eu and Sm were synthesized successfully using the diketone (1-(4-methoxyphenyl)-3-(4-tert-butylphenyl) propane-1,3-dione) (bmdm) and (L) = 1,10-phenanthroline (phen), 2,2’-bipyridine (bipy) ligands. The coordination modes were determined as bidentate chelate by the FT-IR. The ground state geometry was determined using the Sparkle/AM1 implemented in MOPAC2016 package. Europium complexes exhibit the characteristic emission bands that arise from 5 D0→7 FJ (J = 0-4); the presence of just one 5 D0→7 F0 line transition means that this site is without the center of inversion.Samarium complexes display transitions at 4 G5/2→6 HJ (J = 5/2; 7/2; 9/2 and 11/2), being the 4 G5/2→6 H9/2 the most intense, indicating that the forced electric dipole mechanism is predominant when compared with the magnetic dipole ones. The intensity parameters Ω2 and Ω4 were calculated according to the emission spectra for Eu(III) and absorption spectra for Sm(III). The high Ω2 values demonstrated that the lanthanide ion in bipy or phen complexes is in a highly polarizable chemical environment. The emission lifetime (τ) increases compared with that of precursor aquo complexes, confirming that the non-radiative quenching is minimized. The low quantum efficiency is a result of NIR emissions and non-radiative transitions of Sm(III).
SÍNTESE DE NOVOS 1,2,3-TRIAZÓIS INSPIRADOS NO SRPIN340 E AVALIAÇÃO DE SEUS EFEITOS EM LINHAGEM CELULAR DE GLIOBLASTOMA HUMANO
Authors: Sousa Sara , Teixeira Róbson , Costa Adilson , Aguiar Alex , Fonseca Victor , Lacerda Valdemar , Romão Wanderson , Oliveira Laser , Ribeiro Iára , Nogueira Katiane , Nascimento Claudia , Junker Jochen
Published: July 2021

SYNTHESIS OF NOVEL 1,2,3-TRIAZOLES INSPIRED ON THE SRPIN340 AND EVALUATION OF THEIR EFFECTS ON HUMAN GLIOBLASTOMA CELL LINE. It is herein described the synthesis of a series of thirty novel 1,2,3-triazole1,4-disubstituted compounds inspired on the known SRPKs inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide (SRPIN340) and biological evaluation of them against human glioblastoma multiforme cell line U87MG. Starting with 1-fluoro2-nitro-4- (trifluoromethyl)benzene (1), the substances were prepared via a five-step synthetic route. The crucial step corresponded to the copper-catalyzed cycloaddition reaction between trifluoromethyl phenyl azides and different alkynes. In general, the compounds were obtained with good yields and they were characterized utilizing spectroscopic (IR and NMR) and spectrometric (HRMS) techniques. The evaluation of the synthesized compounds at three different treatment time (24 h, 48 h, and 72 h) and concentrations (50, 100, and 150 µmol L-1) revealed that five derivatives were capable of reducing cell viability by 50% after 72 h of treatment at the highest concentration. On the contrary, three derivatives significantly increased cell viability being this effect more pronounced after 48 h of treatment. In this regard, it stands out the compound 2-((1-(2-morpholino-5-(trifluoromethyl)phenyl)-1H-1,2,3-triazol4-yl)methyl)isoindoline-1,3-dione (7) which increased cell viability in approximately 300% after 48 h of treatment at 100 µmol L-1. The substances that increased cell viaiblity present as common structural features the presence of a saturated nitrogen-containing six-membered ring and carbonylated fragments.
Water and soil environmental vulnerability of artificial oases in arid areas and its temporal and spatial differentiation and evolution
Authors: Xu Cundong , Liu Zijin , Zhu Xinglin , Tian Junjiao , Gu Fengyou , Wang Yan
Published: July 2021

The water and soil environmental vulnerability in arid areas is mainly affected by vegetation, hydrology, terrain, and climate. To accurately evaluate the water and soil environmental vulnerability and its evolution in the Jingtaichuan Pumping Irrigation District in China, this paper, taking 1994, 2006, and 2018 as typical years, selects 13 index factors that directly or indirectly drive the water and soil environmental evolution in this area, and adopts the cloud theory and analytic hierarchy process to determine the weight of each index factor. Spatial analysis technique and supervised classification were used to obtain and standardize the spatial distribution raster maps of each index factor. The multi-source data fusion was performed according to the index weight to analyze the evolution characteristics of soil and water environmental vulnerability. The results showed that soil salinity, vegetation coverage, and land use type have a significant impact on the water and soil environmental vulnerability in this irrigation area, and most of the area is at mild risk. High risk mainly occurs in closed hydrological units in the eastern part of the irrigation area. From 1994 to 2018, the evolution process can be divided into two stages, namely the ‘environmental deterioration stage’ and the ‘environmental restoration stage’. The results showed that the water and soil environment of the irrigation area is developing in a healthy way.
NUMERICAL MODELING OF THE IMPACT OF QUARANTINE MEASURES ON THE DYNAMICS OF THE EPIDEMIOLOGICAL PROCESS BASED ON THE SEIRD MODEL
Authors: Eremeeva Nina I.
Published: July 2021

The COVID-19 epidemic has once again demonstrated the importance of predicting the development of various processes and calculating the consequences. “How effective is the introduction of strict quarantine measures?” and “Will the quarantine be able to stop the epide­mic?” — these questions still have no clear answer.
This article aims to answer these questions using mathematical modeling tools using the SEIRD model, modified to account for the peculiarities of the spread of COVID-19. The SEIRD model belongs to the class of differential dynamic models, which allows quick experimentation to predict the spread of the disease and calculate its influence on the development of certain processes.
Based on numerical modeling, the author demonstrates that insufficient quarantine measures provide only a temporary effect. After they end, with an insufficient level of “population immunity”, the epidemic starts growing again, leading to a second morbidity peak.
This paper presents numerical calculations to track the duration impact and quarantine measures’ severity on the dynamics of the epidemiological process. The results show that strict restrictive measures are not always effective, and strict short-term measures have less effect than softer, but long-term measures.
In addition, the author provides an example of finding the parameters of quarantine measures that ensure fixed limits on the morbidity level during the epidemic.
The Expression of TGF-b1, p38 MAPK, and ERK-1 Protein in Cleft Affected Tissue of the Lip: An Observational Study
Authors: Wihastyoko Herman Yosef Limpat , Sidarta Erdo Puncak
Published: July 2021

Background: Cleft lip is a congenital birth defect caused by many proteins. Transforming growth factor (TGF)-β1, p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated protein kinase (ERK)-1 are proteins which regulate proliferation and apoptosis role during intrauterine period. This study aimed to observe the expression of these proteins in cleft affected tissue of the lip.Materials and Methods: A descriptive study by examining the TGF-β1, p38 MAPK, and ERK-1 immunohistochemical expression of cleft affected tissue of the lip was conducted. Subjects were patients that were participating for the social event held by Plastic Surgery Department, Faculty of Medicine, Univesitas Brawijaya, on December 3-12, 2012 in Nusa Tenggara Timur. Excess lip mucosa (waste tissue) during the operation were stored in 10% formalin then stained by immunohistochemistry for TGF-β1, p38 MAPK, and ERK-1. We counted the average protein expression under the light microscope with 1000x magnification for 20 different fields of view, randomly.Results: Paraffin blocks from 30 subjects were selected. The mean p38 MAPK expression was found to be highest, with the average of 8 per field of view; followed by the mean TGF-β1 expression, with the average of 5 per field of view; and the mean ERK-1 expression was found to be the lowest, with the average of 2 per field of view. Conclusion: Expression of p38 MAPK and TGF-β1 are higher than ERK-1, suggesting that p38 MAPK is in the same signalling pathway as TGF-β1, while ERK-1 is lower, as its role as anti-apoptotic. This is consistent with several previous studies showing that all proteins took part in the development of cleft lip or craniofacial development. Further study needs to be conducted to determine which protein plays the bigger role.Keywords: cleft lip, TGF-β1, p38 MAPK, ERK-1
Healing the Fundamental Unit of Heredity (Gene Therapy): Current Perspective and What the Future Holds
Authors: Sari Bunga Anggreini , Zahra Azalia Talitha , Tasti Ganda Purba , Maritska Ziske
Published: July 2021

The ability to make precise adjustments to the human genome has been a goal of healing in which gene also introduces as the fundamental unit of heredity, in biomolecular technology in genetic diseases have opened new knowledge such as gene therapy. Gene therapy is a technique to repair DNA where its usage is to treat the malignancy and inherited genetic diseases. Gene therapy is a choice to the genetic cloth that goals to remedy a sickness this is hard to deal with or perhaps has no treatment. Currently, gene remedy is done in approaches to patients, specifically embryonic cells and somatic cells, every in vivo and ex vivo. Moral considerations with modification of the difficulty's cells and oversight of regulation and reagents want to be taken into consideration within the gene therapy project. Applications for using gene remedies have begun to be widely used, which include in case of maximum cancers, coronary heart disorder, infectious sicknesses, and others. Gene therapy has spread to a wide range of applications then go beyond the modification of genetic disorders. Advances in genetic modification of cancer cells and immunity and the use of viruses and bacteria to control cancer cells have resulted in many clinical trials and product developments for cancer treatment. The miracles and blessings of gene therapy are might believe, but even though they are being studied and developed now and, in the future, so that the desire for gene therapy may be even better future.Keywords: gene therapy, genetic recombination, gene therapy application
Targeting the NLRP3 Inflammasome in Diabetic Nephropathy
Authors: Yang Ming , Wang Xi , Han Yachun , Li Chenrui , Wei Ling , Yang Jinfei , Chen Wei , Zhu Xuejing , Sun Lin
Published: July 2021

:

Diabetic nephropathy (DN) is one of the most common complications of diabetes
and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a
key role in the pathological process of DN. As the most deeply studied inflammasome,
NLRP3 should not be overlooked in DN. Its abnormal activation accelerates DN progression.
In this review, we summarize our understanding of the structural composition and activation
factors of the NLRP3 inflammasome. Moreover, the relationship between NLRP3
inflammasome activation, and the potential of the NLRP3 inflammasome as a therapeutic
target for DN will also be discussed.
Conformational and Structural Characterization of Carbohydrates and their Interactions Studied by NMR
Authors: Cañada Francisco Javier , Canales Ángeles , Valverde Pablo , de Toro Beatriz Fernández , Martínez-Orts Mónica , Phillips Paola Oquist , Pereda Amaia
Published: July 2021

:

Carbohydrates, either free or as glycans conjugated with other biomolecules, participate in a plethora of essential biological processes. Their apparent simplicity in terms of chemical functionality hides an extraordinary diversity and structural complexity. Deeply deciphering at the atomic level their structures is essential to understand their biological function and activities, but it is still a challenging task in need of complementary approaches and no generalized procedures are available to address the study of such complex, natural glycans. The versatility of Nuclear Magnetic Resonance spectroscopy (NMR) often makes it the preferred choice to study glycans and carbohydrates in solution media. The most basic NMR parameters, namely chemical shifts, coupling constants, and nuclear Overhauser effects, allow defining short or repetitive chain sequences and characterize their structures and local geometries either in the free state or when interacting with other biomolecules, rendering additional information on the molecular recognition processes. The increased accessibility to carbohydrate molecules extensively or selectively labeled with 13C is boosting the resolution and detail which analyzed glycan structures can reach. In turn, structural information derived from NMR complemented with molecular modeling and theoretical calculations can also provide dynamic information on the conformational flexibility of carbohydrate structures. Furthermore, using partially oriented media or paramagnetic perturbations, it has been possible to introduce additional longrange observables rendering structural information on longer and branched glycan chains. In this review, we provide examples of these studies and an overview of the recent and most relevant NMR applications in the glycobiology field.
Phytotherapic Drugs for COVID-19 Treatment: A Scoping Review
Authors: Singh Meenakshi , Trivedi Darshini , Mohapatra Reecha , Bagchi Trisha , Durthi Chandrasai P. , Kuppam Chandrasekhar
Published: July 2021

Background:

The rapid eruption of Coronavirus at the end of 2019 has caused global health crisis
and significant loss to the economy and social well-being. This created a massive shortage of advanced health
facilities with inadequate medicinal supply, further deteriorating human health conditions. On the basis of adverse
effects of the ongoing pandemic, this review has been proposed to evaluate the antiviral efficacy of plant-
based therapeutics, against SARS-CoV-2 (commonly called COVID-19) infection. It highlights the possible
action of the mechanism of phytotherapeutic drugs against coronavirus inhibition, further validated by clinical
trials on herbal formulas is reviewed. Though the experimental studies on COVID-19 treatment are limited, the
undesirable side effects of herbal drugs and unidentified compounds cannot be ignored.

Objective:

We have made an effort to study the prospective plant-derived bioactive entities and their effectiveness
in the treatment of COVID-19 and also emphasize on safety and regulatory concerns of phytomedicines.

Methods:

The methodology involves relevant studies on COVID-19 treatment based on herbal extracts and the
purified bioactive metabolites. The e-literature survey has been done by downloading research articles available
on PubMed (National Library of medicine), Elsevier, and Google scholar search engines. The keywords used
are plant metabolites, natural bioactive, phytotherapeutic drugs, clinical trials, SARS-CoV-2, Coronavirus inhibitors
and herbal extracts.

Results:

The review pays particular attention to the etiological study of the COVID-19 virus and its inhibition
using medicinal plant metabolites as immunomodulatory agents. The application of valuable bioactives like
phenolic compounds, saponins, alkaloids, tannins, flavonoids and terpenoids in preparing herbal formula/drug
has been focused on. The drug resistance of bioactive compounds and their side effects on human health were
discussed for effective phytomedicine, thus, emphasizing the perspectives of phytotherapeutic drugs as a safe
remedy to boost immunomodulatory functions and antiviral activity against COVID-19.

Conclusion:

Altogether, the review presents the action mechanism of plant extracts rich in bioactive compounds
and depicted potential antiviral activity against SARS-CoV-2. These plant bioactive compounds can
serve as lead molecules to develop phytomedicine, ensuring all safety regulations in the clinical trials to treat or
prevent COVID-19 viral infections.
Semiotic Thoughts on Biological Sequence Representations
Authors: Restrepo Guillermo
Published: July 2021

:

The deluge of biological sequences ranging from those of proteins, DNA and RNA to
genomes has motivated to devise models to represent them, which are further used to contrast those
sequences. Here we present a brief bibliometric description of the research area devoted to the
representation of biological sequences and highlight the semiotic elements of this process. Finally,
we argue that this research area must learn from the evolution of mathematical chemistry and try to
avoid its pitfalls.
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches
Authors: Daoud Nour El-Huda , Borah Pobitra , Deb Pran Kishore , Venugopala Katharigatta N. , Hourani Wafa , Alzweiri Muhammed , Bardaweel Sanaa K. , Tiwari Vinod
Published: July 2021

In the drug discovery setting, undesirable ADMET properties of a pharmacophore with good predictive
power obtained after a tedious drug discovery and development process may lead to late-stage attrition. The earlystage
ADMET profiling has brought a new dimension to lead drug development. Although several high-throughput
in vitro models are available for ADMET profiling, the in silico methods are gaining more importance because of
their economic and faster prediction ability without the requirements of tedious and expensive laboratory resources.
Nonetheless, in silico ADMET tools alone are not accurate, and therefore, ideally adopted along with in
vitro and or in vivo methods in order to enhance the predictability power. This review summarizes the significance
and challenges associated with the application of in silico tools as well as the possible scope of in vitro models for
integration to improve the ADMET predictability power of these tools.
H101G Mutation in Rat Lens αB-Crystallin Alters Chaperone Activity and
Divalent Metal Ion Binding
Authors: Wu Yi-Ying , Desu Naveen Kumar Reddy , Lu Shou-Yun , Yu Bi-Yu , Kumar Ramya , Huang Fu-Yung
Published: July 2021

Background:

The molecular chaperone function of αB-crystallins is heavily involved in maintaining lens transparency and the development of cataracts.

Objective:

The aim of the study was to investigate whether divalent metal ion binding improves the stability and αB-crystallin chaperone activity.

Methods:

In this study, we have developed an H101G αB-crystallin mutant and compared the surface hydrophobicity, chaperone activity, and secondary and tertiary structure with the wild type in the presence and absence of metal ions.

Results:

Substitution of His101 with glycine resulted in structural and functional changes. Spectral analysis and chaperone-like activity assays showed that substitution of glycine resulted in a higher percentage of random coils, increased hydrophobicity, and 22±2% higher chaperone-like activity. Whereas in the presence of the Cu2+ ion, H101G exhibited 32±1% less chaperone-like activity compared to the wild type.

Conclusion:

Cu2+ has been reported to enhance the chaperone-like activity of lens α-crystallin. Our results indicate that H101 is the predominant Cu2+ binding site, and the mutation resulted in a partial unfolding that impaired the binding of Cu2+ to H101 residue. In conclusion, this study further helps to understand the important binding site for Cu2+ to αB-crystallin.
Variances in the Expression Profile of the EMT-Related Genes in
Endometrial Cancer Lines In Vitro Study
Authors: Nowakowski Robert , Grabarek Beniamin , Burnat-Olech Anna , Boroń Dariusz , Paul-Samojedny Monika
Published: July 2021

Background:

The aim of the study was to evaluate the variances in the expression pattern of
mRNAs and miRNAs related to the EMT in the Ishikawa (histological grade 1; G1), EC-1A (histological
grade 2; G2), and KLE (histological grade 3; G3) cell cultures under cisplatin treatment.

Methods:

Endometrial cancer cell lines were exposed to 75.22 mg (an average concentration of the drug
used in patients with endometrial cancer) for 12.24 and 48 hours in comparison to the untreated cells
(control). The molecular analysis included: extraction of total RNA, microarray analysis (mRNA and
miRNA), RTqPCR, and the ELISA assay.

Results:

Out of 226 mRNAs associated with the EMT, the number of mRNAs differentially expressed in
endometrial cancer cell cultures treated with cisplatin compared to a control culture was as follows: Ishikawa
line - 87 mRNAs; EC-1A - 84 mRNAs; KLE - 71 mRNAs (p<0.05). The greatest changes in the
Ishikawa line treated with the drug compared to the control were noticed for mRNA STAT1 TGFβ1,
SMAD3, FOXO8, whereas in EC-1A they were mRNA TGFβ1, BAMBI, SMAD4, and in KLE mRNA
COL1A1, FOXO8, TGFβ1. The analysis also showed that miR-106a, miR-30d, miR-300 are common
for all cell lines used in this experiment.

Conclusion:

Cisplatin changes the expression profile of genes associated with EMT in endometrial cancer
cell lines. It seems that the expression pattern of TGFβ1 might be a promising, supplementary molecular
marker of the effectiveness of cisplatin therapy. The analysis showed that miR-30d, miR-300,
and miR-106a are involved in the regulation of the expression of EMT-related genes.
Serum Immunoglobulin G Level and Neutrophils to Lymphocytes Ratio Associated with the Prognosis of Neuromyelitis Optica Spectrum Disorder
Authors: Tong Ying , Wang Li , Liu Kai , Liu Weishi , Li Shen , Song Bo , Xia Zongping , Xu Yuming , Zhang Rui
Published: July 2021

Objective:

To investigate the factors related to the prognosis of Neuromyelitis Optica
Spectrum Disorder (NMOSD) in cerebrospinal fluid and peripheral blood examination.

Methods:

In this study, we enrolled 111 patients who were admitted to the First Affiliated Hospital
of Zhengzhou University between January 2016 and January 2018 and diagnosed with NMOSD.
The patients were divided into the relapse group (n = 48) and remission group (n = 67). Before
treatment, all the patients underwent a routine Cerebrospinal Fluid (CSF) and peripheral blood test
on the second morning of admission. The association between laboratory data and disease prognosis
was evaluated.

Results:

The immunoglobulin G (IgG) level in the serum showed a strong correlation with the relapse
of patients, especially in the aquaporin-4-Antibody (AQP4-Ab) positive group (p<0.01). A
high level of serum IgG concentration was associated with the relapse of NMOSD, especially in
the anti-AQP4 positive group. The area under the Receiver Operating Characteristic (ROC) curve
of serum IgG level was 0.888 (p<0.001, 95%CI: 0.808-0.968). The ratio of Neutrophils to Lymphocytes
(NLR) was associated with the disability degree of NMOSD patients in 3 years. The NLR value
was a linear correlation with final Expanded Disability Status Scale (EDSS) scores; patients
with a high level of NLR value presented an increased degree of disability in the following three
years (R2 = 0.053, p=0.015).

Conclusion:

The serum IgG level and NLR of first-attack patients were correlated with the prognosis
of NMOSD.
Molecular Landscape of Lung Epithelium Contributes to High Severity
and Comorbidities for COVID-19 and Lung Cancer
Authors: Sharma Nilesh Kumar , Sarode Sachin C , Sarode Gargi S , Patil Shankargouda
Published: July 2021

:

The heterogeneous and complex nature of cancer is extensively revealed at molecular,
genetic, and tissue microenvironment levels. Currently, co-occurrence of coronavirus disease 2019
(COVID-19) to lung cancer patients and severity of infections by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been understood at preclinical and clinical levels. However,
molecular and cellular insights are not discussed in those papers that support the increased
COVID-19 severity and comorbidities in several cancer types, including lung cancer patients.
Therefore, this perspective highlights the basis of high severity and comorbidities among lung cancer
patients infected by COVID-19 with an emphasis on translational aspects.
Identifying Functional Modules Using Energy Minimization with Graph Cuts
Authors: Chen Yuanyuan , Fan Xiaodan , Pian Cong
Published: July 2021

Aims:

The aim of this article was to find functional (or disease-relevant) modules using
gene expression data.

Background:

Biotechnological developments are leading to a rapid increase in the volume of transcriptome
data and thus driving the growth of interactome data. This has made it possible to perform
transcriptomic analysis by integrating interactome data. Considering that genes do not exist
nor operate in isolation, and instead participate in biological networks, interactomics is equally important
to expression profiles.

Objective:

We constructed a network-based method based on gene expression data in order to identify
functional (or disease-relevant) modules.

Methods:

We used the energy minimization with graph cuts method by integrating gene interaction
networks under the assumption of the ‘guilt by association’ principle.

Result:

Our method performs well in an independent simulation experiment and has the ability to
identify strongly disease-relevant modules in real experiments. Our method is able to find important
functional modules associated with two subtypes of lymphoma in a lymphoma microarray dataset.
Moreover, the method can identify the biological subnetworks and most of the genes associated
with Duchenne muscular dystrophy.

Conclusion:

We successfully adapted the energy minimization with the graph cuts method to identify
functionally important genes from genomic data by integrating gene interaction networks.

Other:

This study can help us to identify disease-relevant modules which can not be identified by
different expression analysis.
Pure PZT95/5 Ceramics and Its Phase Transition Behavior Under External
Fields
Authors: Nie Hengchang , Cao Fei , Wang Genshui , Dong Xianlin
Published: July 2021

Background:

Compositionally modified Pb(Zr0.95Ti0.05)O3 (PZT 95/5) ferroelectric materials
have been extensively investigated in past decades for many important applications. However, few
study on pure PZT95/5 ceramics have been reported.

Objective:

Herein, pure PZT95/5 ceramics were successfully prepared, and their microstructure and
phase transition behaviors under external fields were studied.

Methods:

The pure PZT95/5 ceramics were prepared by the conventional solid state reaction using a
mixed oxide route. The microstructure and its properties under different external fields were measured.

Results:

The X-ray diffraction patterns indicated that the virgin pure PZT95/5 ceramics exhibit an
orthorhombic antiferroelectric phase, which has also been evidenced by the superlattice reflections in
the SAED pattern. While a rhombohedral ferroelectric symmetry crystal structure was observed in the
poled samples suggesting that an electric field induced antiferroelectric to ferroelectric phase transition
takes place. Pure PZT95/5 ceramics exhibit a quenched ferroelectric hysteresis loop with a remnant
polarization of ~8μC/cm2 under 3.5kV/mm. Temperature dependence dielectric response indicated that
the orthorhombic antiferroelectric to cubic paraelectric phase transition occurs at 225°C, corresponding
to its Curie temperature. A shard depolarization behavior and dielectric anomalies were observed under
~240 MPa hydrostatic pressure.

Conclusions:

The depolarization mechanism of pure PZT95/5 ceramics under hydrostatic pressure is
attributed to the hydrostatic pressure-induced FE-AFE phase transition. These results will offer fundamental
insights into PZT95/5 ceramics for pulsed power supply applications.
WORK SAMPLING METHOD FOR ANALYSIS OF PERFORMANCE AND DETERMINING THE NUMBER OF WORKERS IN THE WAREHOUSE DEPARTMENT
Authors:   Universitas Brawijaya, Indah Kartika Sari Sylvie , Dwi Krisna Winata Bintoro , Puspita Andriani Debrina , Wijayanto Putro Wisnu
Published: July 2021

Industrial competition demands that each company be effective and efficient, hence companies need to make optimal use of resources. The purpose of this research is to determine the productivity of the workers in completing their work and to discover how much workload is caused by the activities carried out. In addition, recommendations for improvements were also given as an effort to reduce the high rate of overtime hours and determine the appropriate number of the workforce at spare parts and raw materials division. The results showed that some workforces have an uneven workload. Meanwhile, based on the results of workload analysis, it can be seen that the workload of the warehouse feeder is classified as a high workload, which is 102%.
TINGKAT KESESUAIAN SOAL TEORI UJI KOMPETENSI KEAHLIAN TEKNIK GAMBAR BANGUNAN DENGAN STANDAR KOMPETENSI NASIONAL BIDANG GAMBAR BANGUNAN
Authors: Malik Abdul
Published: July 2021

ABSTRACT                Phenomena that show the competence of building drawings that are needed in the world of work but have not been studied in schools are the basis of research. It is necessary to measure the level of compatability between the materials being studied with the competencies required by the world of work. The purpose of this study was to determine the suitability level of the content of the skills competency test (UKK) based on the National Competency Standars in the Building Drawing Field. The research method used is comparative descriptive. The subject of this research is the matter of the theory of UKK Building Drawing Engineering. Data were analyzed by comparing the level of competency suitability implemented in the UKK theory problem with the National Competency Standards in Building Drawing Field. The results of the study showed that in the implementation of the UKK Building Drawing Tecnique in theory there were 37 competencies tested. Total competencies at the level of young photographers for vocational graduates are 55 competencies. There are 18 competencies that have not been tested on UKK, so there needs to be an adjustment so that the UKK content goes hand in hand with the work competencies required for building drawing skills. Keywords: expertise competency test, building drawing  ABSTRAK                Fenomena menunjukkan adanya kompetensi gambar bangunan yang diperlukan di dunia kerja tetapi belum dipelajari di Sekolah menjadi dasar dalam pengkajian. Perlu adanya pengukuran tingkat kesesuaian antara materi yang dipelajari dengan kompetensi yang disyaratkan dunia kerja. Tujuan dari pengkajian ini adalah mengetahui tingkat kesesuaian antara konten soal Uji Kompetensi Keahlian (UKK) mengacu pada Standar Kompetensi Nasional Bidang Gambar Bangunan. Metode pengkajian yang digunakan adalah deskriptif  komparatif. Subjek pada pengkajian ini adalah soal teori UKK Teknik Gambar Bangunan. Data dianalisis dengan membandingkan antara tingkat kesesuaian kompetensi yang dilaksanakan dalam soal teori UKK dengan Standar Kompetensi Nasional Bidang Gambar Bangunan. Hasil pengkajian menunjukkan dalam pelaksanaan UKK Teknik Gambar Bangunan secara teori terdapat 37 kompetensi yang diujikan. Total kompetensi pada level juru gambar muda untuk lulus SMK adalah 55 kompetensi. Terdapat 18 kompetensi yang belum diujikan pada UKK, sehingga perlu adanya penyesuaian agar konten UKK beriringan dengan kompetensi kerja yang disyaratkan pada keahlian gambar bangunan.Kata Kunci: Uji Kompetensi Keahlian, gambar bangunan
EFEKTIVITAS MODUL ESTIMASI BIAYA KONSTRUKSI JALAN PADA MATA PELAJARAN ESTIMASI BIAYA KONSTRUKSI DI SMK N 1 PURWOREJO
Authors: Sumardjo Sumardjo , Pratama Galeh Nur Indriatno Putra , Vemantyasto Turas Nur
Published: July 2021

Tujuan kajian ini adalah: (1) mengetahui tahap pengembangan modul estimasi biaya konstruksi jalan pada mata pelajaran Estimasi Biaya Konstruksi dan (2) mengetahui tingkat kelayakan modul estimasi biaya konstruksi jalan pada mata pelajaran Estimasi Biaya Konstruksi untuk siswa kelas XI kompetensi keahlian Desain Pemodelan dan Informasi Bangunan SMK Negeri 1 Purworejo. Pendekatan yang digunakan dalam kajian ini adalah Research and Development. Desain kajian ini menggunakan 4D (four-D) Thiagarajan dengan empat tahapan pokok, yaitu: Define (pendefisian); Design (perancangan); Develop (pengembangan); dan Disseminate (penyebaran). Teknik pengumpulan data melalui angket dengan didukung oleh observasi dan wawancara. Teknik analisis data yang digunakan adalah analisis deskriptif dengan cara mengolah data kuantitatif yang kemudian ditafsirkan menjadi data kualitatif. Hasil kajian menunjukkan bahwa: (1) pengembangan modul pada tahap define menunjukkan belum tersedianya modul estimasi biaya konstruksi jalan, pada tahap design modul disusun sesuai dengan kompetensi dan tujuan pembelajaran yang telah dibuat, pada tahap develop adanya saran dari ahli materi mengenai runtutan materi perlu dibuat lebih terstruktur dan sistematis dilain itu adanya saran dari ahli media mengenai perbaikan penulisan indek tabel dan gambar serta posisi penulisan konten pada halaman landscape, dan pada tahap disseminate penyebaran modul dilakukan kepada guru mata pelajaran Estimasi Biaya Konstruksi; (2) tingkat kelayakan modul estimasi biaya konstruksi jalan menurut ahli materi diperoleh persepsi kelayakan sebesar 3,425 dengan kategori sangat layak, menurut ahli media diperoleh persepsi kelayakan sebesar 2,96 dengan kategori layak, dan menurut guru sebagai pengguna diperoleh persepsi kelayakan sebesar 4 dengan kategori sangat layak.
KESESUAIAN ANTARA KURIKULUM PROGRAM STUDI S1 PENDIDIKAN TEKNIK BANGUNAN UNJ DENGAN KURIKULUM SMK KOMPETENSI KEAHLIAN KONSTRUKSI GEDUNG SANITASI DAN PERAWATAN
Authors: Rustanti Lutfi , Murtinugraha R. Eka , Saleh Rosmawita
Published: July 2021

Penelitian ini bertujuan untuk mengetahui tingkat kesesuaian kurikulum Program Studi S1 Pendidikan Teknik Bangunan di UNJ dengan kurikulum Sekolah Menengah Kejuruan Kompetensi Keahlian Konstruksi Gedung, Sanitasi dan Perawatan. Penelitian ini merupakan penelitian kualitatif deskriptif yang menyajikan hasil data sesuai dengan kenyataan yang ada dengan menggunakan mixed method. Data yang digunakan pada penelitian ini adalah data sekunder yang bersumber dari: (1) Koordinator Program Studi S1 PTB UNJ berupa Rancangan Pembelajaran Semester (RPS) mata kuliah prodi; (2) Ketua Jurusan SMK Kompetensi Keahlian KGSP berupa buku KI/KD. Hasil penelitian ini menunjukan bahwa terdapat kesesuaian antara kurikulum prodi S1 PTB UNJ dengan kurikulum SMK kompetensi keahlian KGSP. Dapat dilihat dari tingkat persentasenya yaitu: (1) Mata pelajaran konstruksi bangunan gedung sebesar 72,4%; (2) Mata pelajaran sistem utilitas bangunan gedung sebesar 55,5%; (3) Mata pelajaran perawatan gedung sebesar 100%; (4) Mata pelajaran estimasi biaya konstruksi, sanitasi dan perawatan sebesar 65,4%; (5) Mata pelajaran produk kreatif dan kewirausahaan sebesar 30%. Dan hasil dari kuesioner mahasiswa PTB UNJ didapatkan tingkat persentase kesesuaiannya yaitu: (1) Mata pelajaran konstruksi bangunan gedung sebesar 75,8%; (2) Mata pelajaran sistem utilitas bangunan gedung sebesar 48,1%; (3) Mata pelajaran perawatan gedung sebesar 62,2%; (4) Mata pelajaran estimasi biaya konstruksi, sanitasi dan perawatan sebesar 80,7%; (5) Mata pelajaran produk kreatif dan kewirausahaan sebesar 34,9%.
Developing self and peer assessment to improve student's appreciative critical ability in learning drama appreciation
Authors: Rohmah Khafidatur , Priyatni Endah Tri , Suwignyo Heri
Published: July 2021

This study aims to develop self and peer assessment instruments to improve students' critical and appreciative abilities in learning drama appreciation. This research was conducted by following the ADDIE model development steps, namely needs analysis, product design, product development, product implementation, and product evaluation. There are two types of data in this study, namely qualitative data and quantitative data. Qualitative data is in the form of suggestions and comments from assessment experts, literature experts, and drama appreciation learning experts, as well as students, while quantitative data is in the form of scores obtained from assessment experts, literature experts, and drama appreciation learning experts, as well as students. Both data were obtained through questionnaire guidelines. The data obtained were then analyzed. For qualitative data analyzed using descriptive analysis techniques, while quantitative data using quantitative descriptive analysis techniques. From the analysis technique used, it is known that the product developed can increase students' critical appreciative abilities by getting an average percentage of 8.3% for the display aspect, 9.7% for the product content aspect, and 90.4% for the language aspect. The three averages were obtained from assessment experts, literary experts, and drama appreciation learning experts. When testing the product, students got an average score of 82.2% on the aspect of 'student impressions of the use of self and peer assessment in increasing students' critical appreciation skills in learning drama appreciation 'and 80.4% on the aspect of' practicality and ease of self and peer assessment for improve students 'appreciative critical abilities in drama appreciation learning'.
Character education strengthening model during learning from home: Ki Hajar Dewantara’s scaffolding concept
Authors: Robiasih Hasti , Setiawan Ari , Dardjito Hanandyo
Published: July 2021

To provide educational and learning services to students during the Covid-19 Pandemic, learning is carried out by learning from home. The disparity in learning achievements, especially related to attitude competencies, is strongly experienced during learning from home. This study aims to integrate attitude values through learning with Ki Hajar Dewantara’s scaffolding concept comprising Identifying, Imitating, Developing, Disseminating respectively. This scaffolding is applied to strengthen the character of junior high school students in Yogyakarta Special Province to become Pancasila Students. This is a Research and Development study which applies a qualitative approach. Respondents to this study were teachers, principals, students, parents and junior high school supervisors in this province. Data were collected using focus group discussion, interview, observation.. Data were analyzed using Miles and Huberman models which comprised data reduction, data display and inference stages. The results of this study is a character education strengthening model during learning from home applying Ki Hajar Dewantara’s scaffolding concept. This model contributes to policy making of character education strengthening during the learning from home online.
Evaluation of TOEFL preparation course program to improve students’ test score
Authors: Maharani Mega Selvi , Putro Nur Hidayanto Pancoro Setyo
Published: July 2021

This research was conducted to evaluate the management program in English village, to maintain the program that is implemented and to increase program quality.  Method used in this study was descriptive qualitative and quantitative research. Model evaluation used CIRO (Context, Input, Reaction, and Outcome) by War, Bird and Rackman. Subject of this reseach were 30 students, 4 tutors, and program director.  Interview, survey, and observation was used for collecting the data. The analyzed quantitative data used descriptive percentage and qualitative data used condensation, data exposure, conclusion drawing and verification. The result of this study comprise; (1) Context in this study considered to participant needed which synchronized to the standard implementation of the TOEFL real test and national standar. (2) Input have been provided well prepared including program plan, tutor qualification, for admission of course participants, and facilities. (3) Reaction of the participants atisfaction was in the satisfactory category and the participant's assessment reaction of the TOEFL program implementation process was in the very good category. (4) Outcome obtained by course participants in the TOEFL scoring has not increased significantly, it has even decreased during the last test.
Changes in Stadium Sports Spectators Customer Experiences
Authors: Glebova Ekaterina , Desbordes Michel , Geczi Gabor
Published: July 2021

Over the centuries, in most countries of the world, stadiums have changed and evolved, and with it, the behaviour and ways of experience of their visitors and spectators have certainly transformed. With improvements in-home entertainment systems and internet connectivity occurring all the time, sports fans have a greater capacity to build themselves a viewing experience that fits their preferred specifications, right in the comfort wherever they are: airplane, hotel, office, or their own room. Subsequently, sports stadiums are in the process of challenge and technological evolution, including implementation of various innovations. It attempts to create smooth, strong impressive experience and appeals to attract spectators out of their mediatory watching and to bring them into the stadium, wherever it is situated. In the current paper we investigate and review the critical areas and identify the phenomena of transformations addresses to deliver a next-generation stadium experience that is affective enough to compete with the cost, comfort, impressions benefits of “mobile” spectatorship (Thomson, Potter, 2017). A multidimensional content analysis (Tharenou, 2010) of collected data let us outline the key area of stadium technological transformation, referring to the customer-centric approach (McAlexander et al., 2002; Zaky & Neely, 2018). We define and outline the key areas of changes in SSCX in order to better predict their nature, courses and impact, projecting future perspective research directions.
A látvány-csapatsportágak nemzetközi és hazai sportegészségügyi szabályzatainak áttekintése, különös tekintettel az agyrázkódásra
Authors: Nagy Attila , Kiss Csaba , Boros Anita , Géczi Gábor
Published: July 2021

A magyar sporttörvény előírja a sportszövetségek részére saját sportegészségügyi szabályzataik elkészítését és használatát. Jelen munka során áttekintettük, és az agyrázkódás szempontjából összegeztük a szabályzatokat. Az agyrázkódás súlyos sérülés, amelyre egyes nemzetközi szakszövetségek szabályzatai is külön kitérnek. Az agyat érő sérülésekkel kapcsolatban az orvostudomány a mai napig új megállapításokat tesz, ezért vizsgálatunkat a sporthoz közelebb álló menedzsment szemszögből végeztük, a nemzetközi és hazai szabályzatok áttanulmányozása segítségével. A Magyar Labdarúgó Szövetség (MLSZ) és a Magyar Jégkorong Szövetség (MJSZ) szabályzatában sem a fejsérülésekről, sem az agyrázkódásról nem tesz említést. A Magyar Kosárlabdázók Országos Szövetsége (MKOSZ), a Magyar Kézilabda Szövetség (MKSZ) és a Magyar Röplabda Szövetség (MRSZ) szabályzatai nem elérhetőek a honlapjukon. A Magyar Vízilabda Szövetség (MVLSZ) idevonatkozó szabályzata megemlíti az agyrázkódást, de további protokollt nem ír elő. A válogatott keretorvosok visszajelzései alapján ismeretterjesztő képzések megszervezése, valamint a magyar nyelvű protokollok elkészítése és elterjesztése is szükséges lenne. Amennyiben az agyrázkódás bekövetkezik, akkor a felismerés és a kezelési utasítások betartása kiemelten fontos, ugyanakkor ez komoly kihívás elé állítja a sportolót, hiszen a gyógyulás során a türelem és a pihenés a két kulcstényező. A megelőzés és a kezelés terén az agyrázkódással kapcsolatos ismeretek terjesztése elengedhetetlen, hiszen így a sportoló és környezete sem becsüli alá ennek a sérülésnek a súlyát, lehetséges következményeit.
Readiness for Use of HIV Preexposure Prophylaxis Among Men Who Have Sex With Men in Malawi: Qualitative Focus Group and Interview Study
Authors: Mpunga Elizabeth , Persaud Navindra , Akolo Christopher , Boyee Dorica , Kamanga Gift , Trapence Gift , Chilongozi David , Ruberintwari Melchiade , Masankha Banda Louis
Published: July 2021

Background

Men who have sex with men (MSM) are a key group for HIV interventions in Malawi considering their high HIV prevalence (17.5% compared to 8.4% among men in the general population). The use of oral preexposure prophylaxis (PrEP) presents a new opportunity for MSM to be protected. We present the findings from a qualitative assessment designed to assess awareness of and willingness and barriers to using PrEP among MSM in Malawi.

Objective

The 3 main objectives of this assessment were to determine: (1) awareness of PrEP, (2) factors that influence willingness to use PrEP, and (3) potential barriers to PrEP use and adherence among MSM in order to guide the design and implementation of a PrEP program in Malawi.

Methods

Ahead of the introduction of PrEP in Malawi, a qualitative study using in-depth interviews (IDIs) and focus group discussions (FGDs) was conducted in October 2018 in Blantyre, Lilongwe, and rural districts of Mzimba North and Mangochi. With support of members of the population, study participants were purposively recruited from 4 MSM-friendly drop-in centers where MSM receive a range of health services to ensure representativeness across sites and age. Participants were asked what they had heard about PrEP, their willingness to use PrEP, their barriers to PrEP use, and their preferences for service delivery. The data were analyzed using a thematic content analysis framework that was predetermined in line with objectives.

Results

A total of 109 MSM were interviewed—13 through IDIs and 96 through FGDs. Most participants were aware of PrEP as a new HIV intervention but had limited knowledge related to its use. However, the majority were willing to use it and were looking forward to having access to it. IDI participants indicated that they will be more willing to take PrEP if the dosing frequency were appropriate and MSM were involved in information giving and distribution of the drug. FGD participants emphasized that places of distribution and characteristics of the service provider are the key factors that will affect use. Knowing the benefits of PrEP emerged as a key theme in both the IDIs and FGDs. Participants highlighted barriers that would hinder them from taking PrEP such as side effects which were cited in IDIs and FGDs. Key factors from FGDs include cost, fear of being outed, drug stockouts, fear of being known as MSMs by wives, and lack of relevant information. FGDs cited stigma from health care workers, forgetfulness, and community associated factors.

Conclusions

Despite having inadequate knowledge about PrEP, study participants were largely willing to use PrEP if available. Programs should include an effective information, education, and communication component around their preferences and provide PrEP in MSM-friendly sites.