bluuebunny/crossref_metadata_2025 huggingface dataset:
Pacemaker lead-induced tricuspid stenosis treated with percutaneous valvotomy
Authors: Çetiner Nilüfer , Baştuhan Işıl Yıldırım , Özyiğit Tolga , Mutluer Ferit Onur , Çeliker Alpay
Published: August 2020

Background. Tricuspid stenosis is an uncommon complication of ventricular pacemaker electrode implantation, with few cases reported in the literature.
Case. We present an 18-year-old male who developed severe tricuspid stenosis 15 years after endocardial VVI pacemaker implantation for complete AV block following a surgically repaired ventricular septal defect.
Conclusion. In this case we have shown that percutaneous balloon valvuloplasty was performed and successful in treating this complication.
Type 4 hypersensitivity development in a case due to mifamurtide
Authors: Şimşek Meral , Ataş Erman , Bağrıaçık Emin Ümit , Günal Armağan , Ünay Bülent
Published: August 2020

Background. This report aims to discuss the mechanism of pleural and pericardial effusion related to mifamurtide which is an immunological agent used as adjuvant chemotherapy in osteosarcoma.
Case. Mifamurtide (2 mg/m < sup > 2 < /sup > ) and European and American Osteosarcoma Studies (EURAMOS) protocol were used together intravenously after complete surgical resection. No side effects occurred except for fever after the first dose. However, pleural, pericardial effusion, and splenic nodule formation began 11 months after discontinuation of mifamurtide treatment. Pleural biopsy revealed a type 4 hypersensitivity reaction. We treated the patient with 1,5 mg per day colchicine. Pericardial effusion attacks and nodules in the spleen disappeared. The patient had a mild pleural effusion attack which has not yet repeated.
Conclusion. Mifamurtide, which activates macrophages, can also activate immunity with a stand by effect and cause a hypersensitivity reaction.
Selection for yield and its component traits in interspecific recombinant inbred lines of tef
Authors: Worede Fisseha , Tefera Hailu
Published: August 2020

Forty recombinant inbred lines (RILs) of interspecific cross of Eragrostis tef x E. pilosa were evaluated to study variability and interrelationships among agronomic traits using randomized complete block design. The RILs were evaluated for 17 traits. The result showed panicle length, rind penetrometer resistance of the first and the second basal internodes, 100-kernel weight, kernel weight per panicle, plant height and grain yield per plant had high estimates of genetic coefficient of variation, broad sense heritability and genetic advance. Thus, improvement of these traits could be attained through direct selection without the masking effect of the environment. The correlation study showed positive and significant (p<0.01) phenotypic and genotypic associations of grain yield per plant with days to heading and maturity, panicle length, 100-kernel weight, kernel weight per panicle, biomass yield per plant and harvest index. Genotypic path coefficient analysis revealed that panicle length, biomass yield per plant, crushing strength of the second basal internode, harvest index, days to heading and kernel weight per panicle exerted appreciable positive direct effect on grain yield per plant. These traits could, therefore, be considered as indirect selection criteria while selecting lines in order to improve grain yield of the interspecific population.
СУЧАСНИЙ СТАН ГЕОДЕЗИЧНОГО МОНІТОРИНГУ АЕРОДРОМНИХ ПОКРИТТІВ В УКРАЇНІ
Authors: Kryachok Serhiy
Published: August 2020

Актуальність теми дослідження. В Україні нині діє Державна цільова програма розвитку аеропортів. Програмою передбачено стабільний розвиток авіаційної галузі в Україні, модернізацію та реконструкцію навних і будівництво нових аеродромів та аеродромних об’єктів, зокрема поверхонь, призначених для посадки, зльоту, руху, стоянки повітряних суден, руху наземного транспорту на території аеродрому, ґрунтових елементів аеродрому. Постановка проблеми. Нині значно розширився авіаційний парк в Україні та за її межами. З’явились тяжкі та надтяжкі повітряні судна. Збільшення ваги повітряних суден веде до підвищення навантаження на аеродромні покриття. Це, у свою чергу, призводить до більш швидкого зношення аеродромних покриттів та появи дефектів, які загрожують безпеці польотів, зміні профілю покриття. Тому проводиться постійний моніторинг за станом аеродромних покриттів. Аналіз останніх досліджень і публікацій. Були розглянуті останні публікації у відкритому доступі, які присвячені моніторингові аеродромних покриттів. Виділення недосліджених частин загальної проблеми. Аналіз засобів та методів геодезичного моніторингу аеродромних покриттів дозволяє зробити висновок, що геодезичний моніторинг спрямований лише на визначення
профілю покриттів. Дефекти аеродромних покриттів не є предметом геодезичного моніторингу.
Мета статті. Головною метою цієї статті є виконати огляд конструкцій аеродромних покриттів та їхніх
дефектів. Виклад основного матеріалу. Наведено класифікації аеродромних покриттів та виконано огляд конструкцій жорстких, асфальтобетонних, полегшених, спрощених покриттів та ґрунтової частини льотного поля. Наведено особливості дефектів аеродромних покриттів і основні причини їх виникнення. Дефекти згруповані в окрему таблицю та виконано їх візуалізацію. Висновки відповідно до статті. У результаті аналізу засобів та методів геодезичного моніторингу стану аеродромних покриттів встановлено, що основним видом такого моніторингу є визначення лише нерівностей поверхні покриттів. Для виявлення більш широкого спектра дефектів аеродромних покриттів необхідне залучення безпілотних літальних апаратів, лазерного сканування та розробка новітніх засобів та методів моніторингу аеродромних покриттів.
ПОРІВНЯЛЬНИЙ АНАЛІЗ ЕКСПЕРИМЕНТАЛЬНИХ ДОСЛІДЖЕНЬ ТА ЧИСЕЛЬНИХ РОЗРАХУНКІВ МІЦНОСТІ ВКЛЕЄНИХ СТРИЖНІВ У CLT ПАНЕЛЯХ
Authors: Bidakov Andrii , Pustovoitova Oksana , Raspopov Ievgenii , Strashko Bogdan
Published: August 2020

Актуальність теми дослідження. Позитивний досвід використання вклеєних сталевих стрижнів у дерев’яних конструкціях спостерігається протягом тривалого періоду в Східній Європі і вважається за необхідне застосування даного типу з’єднань в панелях з поперечної клеєної деревини (ПКД або CLT).
Постановка проблеми. Міцність вклеєних стрижнів на висмикування, які встановлені у поперечному перерізі ПКД або CLT панелі показали нові результати, які важко було передбачити з урахуванням значної практики використання вклеєних стрижнів у цільній та клеєній деревині. ПКД панель є складною багатошаровою системою дошок зі взаємно перпендикулярним їх розташуванням у суміжних шарах, то виникли нові граничні умови для стрижнів, коли вони можуть бути розташованими на межі повздовжньої та поперечної дощок. Аналіз останніх досліджень і публікацій. Аналіз міцності вклеєних стрижнів на висмикування залежно від положення в поперечному перерізі аналогічно випробуванням, описаним в роботі проф. H. J. Blass при дослідженні міцності гвинтів на висмикування, де місце встановлення гвинтів варіювалося Виділення недосліджених частин загальної проблеми. Не вирішено питання впливу місця розташування стрижня в поперечному перерізі ПКД панелі на величину його несучої здатності. Постановка завдання. Провести порівняльний аналіз експериментальних досліджень та чисельних розрахунків міцності вклеєних стрижнів у CLT панелях.
Виклад основного матеріалу. Для оцінки достовірності отриманих експериментальних даних виконані аналітичні дослідження в програмному комплексі Ansys для всіх можливих місць розташування стрижнів у поперечному перерізі ПКД панелі, що можуть впливати на величину міцності, з урахуванням пружної моделі анізотропії деревини. Виконані дослідження вказують на те, що небажано виконувати вклеювання стрижнів у крайні дошки, навіть при встановлені групи вклеєних стрижнів, що також потребує додаткових комплексних варіативних експериментальних досліджень для формулювання конструктивних вимог щодо компоновки вузлів на вклеєних стрижнях у ПКД панелях.
Висновки відповідно до статті. На основі експериментальних досліджень міцності вклеєних стрижнів у поперечному перерізі ПКД або CLT панелі встановлено зміну міцності залежно від діаметра металевого стрижня та його місця розташування у поперечному перерізі, якому характерно чергування взаємно поперечних шарів дошок.
Remdesivir Strongly Binds to both RNA-dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations
Authors: Nguyen Hoang Linh , Nguyen Thai , Truong Duc Toan , Li Mai Suan
Published: August 2020

The outbreak of a new coronavirus SARS-CoV-2 (severe acute respiratory syndrome–

coronavirus 2) has caused a global CoVid-19 (coronavirus disease 2019) pandemic, resulting in millions of infections and thousands of deaths around the world. There is currently no drug or vaccine for CoVid-19, but it has been revealed that some commercially available drugs are promising, at least for treating symptoms. Among them, Remdesivir, which can block the activity of RNA-dependent RNA polymerase (RdRp) in old SARS-CoV and MERS-CoV viruses, has been prescribed to CoVid-19 patients in many countries. A recent experiment showed that Remdesivir binds to SARS-CoV-2 with an inhibition constant of μM, but the exact target has not been reported. In this work, combining molecular docking, steered molecular dynamics and umbrella sampling we examined its binding affinity to two targets including the main protease (Mpro), also known as 3C-like protease, and RdRp. We showed that Remdesivir binds to Mpro slightly weaker than to RdRp and the corresponding inhibition constants, consistent with the experiment, fall to the μM range. The binding mechanisms of

Remdesivir to two targets differ in that electrostatic interaction is the main force in stabilizing the RdRp-Remdesivir complex, while the van der Waals interaction dominates in the MproRemdesivir case. Our result indicates that Remdesivir can target not only RdRp but also Mpro, which can be invoked to explain why this drug is effective in treating Covid-19. We have identified residues of the target protein that make the most important contribution to binding affinity, and this information is useful for drug development for this disease.
Reductive Hexamerization of CO Involving Cooperativity Between Magnesium(I) Reductants and [Mo(CO)6]: Synthesis of Well-Defined Magnesium Benzenehexolate Complexes
Authors: Paparo Albert , Yuvaraj K. , Matthews Aidan J. R. , Douair Iskander , Maron Laurent , Jones Cameron
Published: August 2020

The first examples of magnesium benzenehexolate complexes are prepared by reductive hexamerizations of CO, in reactions that are initiated (or catalyzed) by [Mo(CO)6]. These reactions are closely related to Justus von Liebig’s classical 1834 study on the reduction of CO gas with molten potassium, which yields K6C6O6 (amongst other products), by an as yet unknown mechanism.
Evaluation of a Platinum–Acridine Anticancer Agent and Its Liposomal Formulation in an In Vivo Model of Lung Adenocarcinoma
Authors: Ding Song , Hackett Christopher L. , Liu Fang , Hackett Ryan G. , Bierbach Ulrich
Published: August 2020

Liposomal formulations have been developed for a highly cytotoxic platinum–acridine hybrid agent, [PtCl(pn)(C18H21N4)](NO3)2 (PA, pn = propane-1,3-diamine), and fully characterized. PEGylated nanoliposomes consisting of hydrogenated soybean phosphatidylcholine (HSPC), anionic 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1´-rac-glycerol) (DPPG), and polyethylene glycol-2000-distearoylphosphatidylethanolamine (DSPE-mPEG2k) were able to stably encapsulate PA at payload-to-lipid ratios ranging from approximately 2–20%. The fusogenic properties of the liposomes promote efficient cellular uptake of PA across the plasma membrane, which results in vesicular transport of payload to the nucleus, as confirmed by confocal fluorescence microscopy in cultured lung cancer cells. Unencapsulated PA and one of the newly designed liposomal formulations show promising efficacy in tumor xenografts derived from A549 cells (human lung adenocarcinoma). The findings underscore the utility of platinum–acridine agents for treating aggressive, chemoresistance cancers and validate nanoliposomes as a biocompatible, expandable platform for their intravenous delivery and other potential routes of administration.
Automated, Accurate, and Scalable Relative Protein-Ligand Binding Free Energy Calculations using Lambda Dynamics
Authors: Raman E. Prabhu , Paul Thomas J. , Hayes Ryan L. , Brooks III Charles L.
Published: August 2020

Accurate predictions of changes to protein-ligand binding affinity in response to chemical modifications are of utility in small molecule lead optimization. Relative free energy perturbation (FEP) approaches are one of the most widely utilized for this goal, but involve significant computational cost, thus limiting their application to small sets of compounds. Lambda dynamics, also rigorously based on the principles of statistical mechanics, provides a more efficient alternative. In this paper, we describe the development of a workflow to setup, execute, and analyze Multi-Site Lambda Dynamics (MSLD) calculations run on GPUs with CHARMm implemented in BIOVIA Discovery Studio and Pipeline Pilot. The workflow establishes a framework for setting up simulation systems for exploratory screening of modifications to a lead compound, enabling the calculation of relative binding affinities of combinatorial libraries. To validate the workflow, a diverse dataset of congeneric ligands for seven proteins with experimental binding affinity data is examined. A protocol to automatically tailor fit biasing potentials iteratively to flatten the free energy landscape of any MSLD system is developed that enhances sampling and allows for efficient estimation of free energy differences. The protocol is first validated on a large number of ligand subsets that model diverse substituents, which shows accurate and reliable performance. The scalability of the workflow is also tested to screen more than a hundred ligands modeled in a single system, which also resulted in accurate predictions. With a cumulative sampling time of 150ns or less, the method results in average unsigned errors of under 1 kcal/mol in most cases for both small and large combinatorial libraries. For the multi-site systems examined, the method is estimated to be more than an order of magnitude more efficient than contemporary FEP applications. The results thus demonstrate the utility of the presented MSLD workflow to efficiently screen combinatorial libraries and explore chemical space around a lead compound, and thus are of utility in lead optimization.
Thymine Dimerization Induced by Oxidative DNA Lesions and Epigenetic Intermediates via Triplet-Triplet Energy Transfer
Authors: Lineros-Rosa Mauricio , Francés-Monerris Antonio , Monari Antonio , Miranda Miguel Angél , Lhiaubet-Vallet Virginie
Published: August 2020

Interaction of nucleic acids with light is a scientific question of paramount relevance not only in the understanding of life functioning and evolution, but also in the insurgence of diseases such as malignant skin cancer and in the development of biomarkers and novel light-assisted therapeutic tools. This work shows that the UVA portion of sunlight, not absorbed by canonical DNA nucleobases, can be absorbed by 5-formyluracil (ForU) and 5-formylcytosine (ForC), two ubiquitous oxidative lesions and epigenetic intermediates present in living beings in natural conditions. We measure the strong propensity of these molecules to populate triplet excited states able to transfer the excitation energy to thymine-thymine dyads, inducing the formation of the highly toxic and mutagenic cyclobutane pyrimidine dimers (CPDs). By using steady-state and transient absorption spectroscopy, NMR, HPLC, and theoretical calculations, we quantify the differences in the triplet-triplet energy transfer mediated by ForU and ForC, revealing that the former is much more efficient in delivering the excitation energy and producing the CPD photoproduct. Although significantly slower than ForU, ForC is also able to harm DNA nucleobases and therefore this process has to be taken into account as a viable photosensitization mechanism. The present findings evidence a rich photochemistry crucial to understand DNA photodamage and of potential use in the development of biomarkers and non-conventional photodynamic therapy agents.
An Overview of Coronaviruses: In-Silico Approach to Decipher Anti-SARS-CoV-2 Natural Products
Authors: Suresh Patil Shivprasad , Gupta Shiv Shankar , Sharma Anmol , Sharma Upendra
Published: August 2020

In current study, we have focused on the outline of different coronaviruses including COVID-19, along with potential therapeutic targets of SARC-CoV-2. Moreover, experimentally evident anti-coronavirus natural molecules were subjected for in silico screening against Mpro and RdRp of COVID-19, in order to predict effective cure agent for same.Docking analysis have revealed hit molecules namely tetra-O-galloyl-β-D-glucose (2) and juglanin (25) against main protease, in reference of N3 molecule (docking score = -5.95 Kcal/mol), while glycyrrhizin (1) and tetra-O-galloyl-β-D-glucose (2) are good against RdRp in reference of Remdesivir (docking score = -4.23 Kcal/mol). In-silico parameter revealed three lead compounds i.e. glycyrrhizin (1), tetra-O-galloyl-β-D-glucose (2) and juglanin (25) which can be seen as hopeful molecule for COVID-19 treatment in upcoming time. Overall review lesson is to develop a specific and effective drug molecule against the current crisis i.e. COVID-19 derived from natural source.
Cytotoxic Effect of Aqueous and Ethanolic Bark Extracts of Alstonia Scholaris against Cervical Cancer Cell Line
Authors: Jayashree V  , Akshara Rajeswari RS  , Bharath M  , Amaraegbu Paschal Izuchukwu  , Lavanya  , Haneef Sharif  , Jeeva Raj
Published: August 2020

Alstonia scholaris, a tropical evergreen tree belonging to the family Apocynaceae has traditionally been referred to have anti-cancer activity, but it has not been explored so far. Therefore, the study is aimed to investigate the cytotoxic effect of aqueous and ethanolic bark extracts of Alstonia scholaris against cervical cancer cell line (HeLa Cell line). The bark part of Alstonia scholaris was collected, dried, powdered and made to a coarse powder. Maceration was carried out for the bark of Alstonia Scholaris using two different solvents like ethanol and aqueous solutions. Both the extracts were collected, evaporated to dryness. The extracts were then investigated for the phytochemical screening and cytotoxic effect by MTT Assay using cervical cancer cell line (HeLa cell line). The phytochemical screening of both the extracts showed the presence of various phytoconstituents such as alkaloids, flavonoids, glycosides, gums and mucilage. The IC50 value of Alstonia scholaris of aqueous extract was found to be 13.38µg/ml, whereas the IC50 value of ethanol extract was found to be 14.21µg/ml. According to the results obtained, it has been proved that the aqueous and ethanolic extracts of Alstonia Scholaris bark showed the presence of significant phytoconstituents and also showed significant cytotoxic effect (MTT Assay) against cervical cancer.
Impact of low back pain on fear of movement and functional activities
Authors: Waqar M Naqvi  , Laukik Vaidya  , Kiran Kumar
Published: August 2020

Fear is an uncomfortable feeling, which results from the proximity of actual threat or pain. A strong correlation exists between fear and pain. Kinesiophobia is the phobia of activity and physical movement, which results from a sensation of sensitivity to painful injury or reinjury. Low back pain (LBP) is among the frequent disorders of the musculoskeletal system. LBP is mainly due to bad postures and poor organisational ergonomics. Kinesiophobia has adverse effects on rehabilitation outcomes. So the systematic application of graded exposure to movements is recommended in patients with Kinesiophobia to prevent pain-related anxiety. We compared Kinesiophobia's impact on patients with both acute and chronic LBP. We aimed to find out the role of Kinesiophobia in patients having LBP. The survey-based research using Tampa scale of Kinesiophobia was conducted with cross-sectional design. It included participants of both genders,in the age group of 18-65 who were diagnosed with acute and chronic low back pain. Tampa Scale for Kinesiophobia, Evaluation Performa, NPRS and Goniometer were used as outcome measures for the study. The patients were thoroughly examined, and they were evaluated using the Tampa Scale. Scoring to 17-items Tampa Scale was performedin4-point Likert scale varying from “strongly disagree” to “strongly agree.” After the inversion of items 4, 8, 12, 16, the final score was determined. The total score ranges from a minimum of 17 to a maximum of 68. It was concluded that Kinesiophobia plays a crucial role in LBP, especially chronic LBP.
Phytochemical Screening and In Vitro Antibacterial Activities of Leaf Extract Acacia etbaica Schweinf Against Multidrug Resistant Enterobacteriaceae Human Pathogens
Authors: Tekleweyni Tadege  , Kidu Hintsa  , Tesfay Weletnsae  , Gopalakrishnan V K  , Muthulingam M  , Kamalakararao K  , Krishna Chaithanya K
Published: August 2020

Acacia etbaica Schweinf belongs to the family Fabaceae widely distributed in Africa and various parts of this plant such as bark, leaves, flowers and roots are widely used as a folk medicine for curing of various ailments.This study was aimed to screen the phytoconstituents and evaluate the antibacterial activity of leaf extract of A. etbaica against selected multidrug resistant Enterobacteriaceae family. Leaves of A. etbaica were extracted with petroleum ether, chloroform, acetone, and ethanol by sequential soxhlet extraction. Phytochemical screening of organic leaf extract of A.etbaica was carried out for the detection of phytoconstituents accountable for antibacterial activity. In vitro antibacterial activities of A.etbaica leaf extracts against selected Enterobacteriaceae family gram‑positive bacteria such as (B.subtilis, E.faecalis,S.aureus)and gram-negative (E. coli, K. pneumonia, V. cholera) were evaluated by agar well diffusion. The antibacterial potential of acetone and ethanol leaf extracts of A.etbaica were determined by 96 well plate broth dilution assay. Among the tested organic leaf extracts, both acetone and ethanolic leaf extract of A.etbaica showed a potentially broad spectrum of in vitro antibacterial activity against tested multiple drug resistant Enterobacteriaceae family gram-positive pathogens such as B.subtilis, E. faecalis , and S.aureus and gram-negative bacterial strains E. coli, K. Pneumonia and V. Cholera with significant MIC values. The significant antibacterial activity of both acetone and ethanolic leaf extracts of A.etbaica was due to the subsistence of secondary metabolites phytoconstituents such as flavonoids and phenolic compounds.
Physico-Chemical Analysis of Mango Juice Factory Efϑluent (MJFE) and its phytotoxic effects of Gingelly (Sesamum indicum L.)
Authors: Sivakumar V P  , Lenin M
Published: August 2020

The use of bottled fruit beverages has increased enormously. The increased consumption increases the public and sewerage industries. It also leads to various sewerage industries problems. The juice factories use large quantities of water which in turn produces large amounts of wastewater that is called ‘effluent’. This effluent contains a large amount of chemicals and organisms from fruits, sugars and additives like colours. The classical juice factory generates 10 litres of ‘effluent’ per litre of juice. Anextensive range of mangoes are used to make juice; the large quantity of effluent is discharged into nearby water bodies or open agricultural land. The researchers are working on the solution to avoid this. One of the researches we tried to solve the problem of using dilution methods was a physicochemical analysis of mango juice effluent and its phytotoxic effects on gingelly. The laboratory experiment was carried outon the phytotoxic effects of mango juice factory effluent (MJFE)on the growth of Gingelly (Sesamum indicum L.). The different concentrations of effluent(Control, 5, 25, 50, 75and 100%) were prepared, after the seeds sowing the mud pots the treatments were given, the germination percentage(G.P.), vigour index (VI), tolerance index (T.I.), phytotoxicity (P) were recorded in 7thDAS. The growth parameters such as shoot length (S.L.), root length (R.L.), number of leaves (N.L.), total leaf area (TLA), fresh weight (F.W.) and dry weight (D.W.) were inspected on 30th DAS of seedlings.The results were exposed after germination characters, and morphological parameters increased (up to5%) effluent concentration and after that declined in higher (above 25%) concentration of MJFE. Because the effluent is toxic, it contains large quantities of organic and inorganic chemicals and high intensity of BOD, COD and others.
Presentación
Authors: Bernal Lugo Ricardo
Published: August 2020

En el número actual de LOGOS Revista de Filosofía el Dr. Alberto Luis López y la Dra. Alejandra Velázquez Zaragoza han coordinado un Dossier sobre la obra del filósofo irlandés George Berkeley. Como señalan ambos colaboradores, a pesar de que la obra del autor de A Treatise concerning the Principles of Human Knowledge ha sido ampliamente estudiada en el mundo anglosajón, francófono y europeo en general, no ha tenido el mismo eco en los países de habla hispana por lo que los cinco artículos presentados en este número alrededor del pensamiento berkeleyano pueden ayudar a ampliar los debates tanto sobre la influencia del irlandés en la historia de la filosofía como en aspectos puntuales de la filosofía de la ciencia, la ontología o la filosofía de la mente.
La noción de “cúmulo (congeries) de percepciones” en los Comentarios filosóficos de George Berkeley [The notion of ‘congeries (cúmulo) de percepciones’ in the Philosophical Commentaries of George Berkeley]
Authors: Castro Chavarría Hazel
Published: August 2020

Durante la época moderna predominó la idea de que no podíamos explicar la ejecución de nuestros actos mentales sin admitir la existencia de un sujeto que llevara a cabo dicha actividad. Esto último repercutió de manera importante en la aceptación de la propuesta que en el Tratado de la naturaleza humana David Hume hiciera en torno al ‘yo’; que éste consistía únicamente en ser un haz de percepciones. Sin embargo, esta concepción no era nueva. Ya en los Comentarios filosóficos de George Berkeley encontramos vestigios de una noción similar. Esta concepción, como observaremos, dejaría fuera cualquier representación de la mente en términos de una entidad independiente de nuestras percepciones que, además, ejecutaría las actividades propias de una vida mental. Finalmente, el eje de esta breve investigación girará en torno al supuesto de que no habría una sustancia espiritual individual distinta a un conjunto (haz/cúmulo) de percepciones.
Palabras clave
Actos mentales; Yo; Entidad independiente; Sustancia espiritual individual; Haz/Cúmulo de percepciones
 
Referencias
Berkeley, George. Comentarios filosóficos. Introducción manuscrita a los Principios del conocimiento humano. Correspondencia con Johnson. Traducido por José Antonio Robles. México: Instituto de Investigaciones Filosóficas-UNAM, 1989.
_____________________ Tratado sobre los principios del conocimiento humano. Traducido por Carlos Mellizo. Madrid: Alianza, 2014.
Castro, Hazel. “La idea de una ‘mente singular’ en Hume: el ‘qué o quién’ ejecuta las actividades propias de una vida mental”, en Laura Benítez y Luis RamosAlarcón (coords.), El concepto de sustancia de Spinoza a Hegel, UNAM, 2018.
Descartes, René. Meditaciones metafísicas y otros textos. Traducido por E. López y M. Graña. Madrid: Gredos, 1997.
Hume, David. Tratado de la naturaleza humana. Traducido por Félix Duque. Madrid: Tecnos, 1988. Locke, John. Ensayo sobre el entendimiento humano. Traducido por E. O’Gorman. México: Fondo de cultura económica, 2005.
Mellizo, Carlos. En torno a David Hume: Tres estudios de aproximación. Zamora: Ediciones Monte Casino, 1978.
Olson, Eric T., “Personal Identity”, The Stanford Encyclopedia of Philosophy (Fall 2019 Edition), Edward N. Zalta (ed.), URL = 
Robles, José Antonio.“Génesis de la noción de sustancia desde George Berkeley I.” Diánoia, Vol. 30, no. 30, 1984.
Las visiones de Ernesto Laclau y los trucos de Chantal Mouffe1
Authors: Bidet Jacques
Published: August 2020

la teoría. Por lo mismo, el populismo de izquierda se ha acompañado de “nuevos fi lósofos” creadores de una “nueva izquierda” y de un “nuevo pueblo”. Sin duda, en Europa del Sur los más notables son Ernesto Laclau y Chantal Mouff e, pareja en la vida privada y en el trabajo teórico. Sin embargo, para apreciar su contri- bución, para comprenderla, es necesario desasociarlos, seguir el desarrollo de sus respectivos enfoques, convergentes políticamente y, a pesar de ello, muy distintos conceptualmente. En este texto me centraré en la contribución de Chantal Mouff e, especialmente en su último libro, Por un populismo de izquierda, aparecido en inglés y en francés en 2018, y que sin duda marca su etapa más reciente. Me parece tanto más apropiado que se dirija, entre otros, a un públi- co francés afi rmando su deuda intelectual con Jean-Luc Mélenchon y François Ruffin2 y su afi nidad política con la Francia Insumisa,3 citada como ejemplo de una elección “partisana”, tal como lo subraya Mouffe.
AS CORRELAÇÕES ENTRE O TRATAMENTO JURÍDICO DA PROPRIEDADE INDUSTRIAL SOBRE FÁRMACOS ANTIRRETROVIRAIS E O DESENVOLVIMENTO NACIONAL
Authors: Leão Neto João Batista de Souza , Guimarães Patrícia Borba Vilar
Published: August 2020

Este artigo analisa as correlações do tratamento jurídico da propriedade industrial sobre fármacos antirretrovirais com o desenvolvimento nacional. Adota-se como método de abordagem o hipotético-dedutivo. A pesquisa realizada é predominantemente teórica, com objetivo explicativo e predominância da abordagem qualitativa. Utiliza-se, ainda, a pesquisa quantitativa, por meio de fontes secundários, a fim de se avaliar possíveis impactos do licenciamento compulsório de patentes. Validaram-se as seguintes hipóteses: o tratamento jurídico das patentes dos antirretrovirais é um instrumento para efetivação do princípio do desenvolvimento nacional; o desenvolvimento nacional fundamenta possível mitigação da propriedade industrial, para fim de licenciamento compulsório de patentes.
ALGORITMOS: códigos invisíveis (d)e injustiça
Authors: Lemes Mariana Carolina , CHIESSE DANIEL ROXO DE PAULA , De Marco Cristhian Magnus
Published: August 2020

Os algoritmos servem para a discussão da opressão digital, permitindo inquirir como algoritmos tendenciosos viabilizam a perpetuação da desigualdade e novas formas de perfilamento racial. Novas tecnologias - algoritmos digitais, em especial - influenciam as percepções e impressões subjetivas e reacendem estereótipos sociais, prejudicando conquistas da segunda dimensão dos direitos fundamentais. É objetivo demonstrar a influência dos algoritmos na sociedade digital. A utilização dos algoritmos para justificação e fortalecimento de relações de poder que vão de encontro com os valores da igualdade. O estudo multidisciplinar segue o procedimento monográfico; técnica de pesquisa baseada na revisão bibliográfica, com aplicação do método hipotético-dedutivo.
Public Health Aspects of the Covid-19 Response and Opportunities for the Post-Pandemic Era
Authors: Wilson Nick , Boyd Matt , Kvalsvig Amanda , Chambers Tim , Baker Michael
Published: August 2020

This article takes a public health perspective on New Zealand’s pandemic preparations, its pandemic response, and the successful outcome (as of June 2020) of its Covid-19 elimination strategy. The health outcome appears to be the best in the OECD, but some other countries made better use of certain control strategies. In the postpandemic era there are many emerging opportunities for society to be gained by embedding better plans for controlling future emerging diseases, strengthening public health infrastructure and consolidating the evident benefits of reduced pollution during the lockdown.
Government’s Income Support Responses to the Covid-19 Pandemic
Authors: Fletcher Michael
Published: August 2020

Income support policy was already a contentious issue before the arrival of Covid-19, but it has assumed increased significance as a result of the job losses and disruption to people’s earnings following the border closures, trade disruption and the period of nationwide lockdown. This article documents the government’s income support and social welfare responses to the pandemic and places them in the context of the pre-existing debates around welfare policy. The article finishes with a brief discussion of possible future directions for the welfare state.
O papel do tradutor/intérprete de língua de sinais como mediador em aulas de física no ensino médio
Authors: Darroz Luiz Marcelo , Tyburski Leticia Piotroski , Rosa Alvaro Becker da
Published: August 2020

As instituições de ensino vêm promovendo debates e reflexões sobre a educação inclusiva, cuja legislação nacional é recente e provoca mudanças no sistema educacional quanto às atitudes sociais estabelecidas ao longo dos anos. Dentre essas mudanças estão as vinculadas às práticas pedagógicas, que demandam metodologias específicas e pertinentes a essa realidade. Além disso, torna-se necessário promover espaços para divulgação dessas metodologias junto aos professores, tanto em cursos de formação inicial como continuada. A situação apresentada circunscreve a investigação descrita neste artigo, cujo objetivo consiste em analisar aspectos do discurso do intérprete de Libras em aulas de Física, o que, muitas vezes, tem se tornado um desafio, considerando as especificidades e a complexidade da área. Para tanto, analisam-se as transcrições de áudio da fala de uma professora de Física em confronto com o discurso elaborado na língua de sinais pela intérprete. Tal análise permite identificar a pertinência na tradução dos exemplos utilizados pela professora de Física, entretanto, revela problemas em termos da discussão dos conceitos físicos envolvidos. Como resultado, o estudo aponta que o profissional em Libras que atua nessa mediação necessita estabelecer melhores aproximações com os professores das disciplinas específicas e que o estudo prévio possibilita alternativas de uma atuação mais eficaz.
Concepções prévias e obstáculos epistemológicos no ensino de atomística: uma abordagem a partir do método educacional psicodramático
Authors: Pascúi Matheus Ziantoni , Altarugio Maisa Helena
Published: August 2020

Dada a importância das concepções prévias dos alunos e a presença de obstáculos epistemológicos que dificultam a compreensão dos modelos atômicos, este trabalho trata de uma experiência com o objetivo de levantar e analisar as concepções de alunos do 8º ano do Ensino Fundamental sobre o conceito de átomo e suas propriedades. A metodologia utilizada na construção, aplicação do instrumento e análise das concepções foi o Método Educacional Psicodramático (MEP), que se preocupa em trazer o aluno para uma posição mais ativa, mais espontânea e criativa frente à aprendizagem. Recursos auxiliares tais como desenhos, discussões coletivas e experimentos simples ajudaram a compor os dados. Embora os resultados não revelem novidades quanto às concepções dos alunos e aos obstáculos epistemológicos neles presentes, existe muita coerência entre os modelos propostos e as explicações para os fenômenos observados, demonstrando a presença de um raciocínio lógico consistente, mesmo quando estão afastados dos conhecimentos cientificamente aceitos. As conclusões reforçam a atenção para os obstáculos epistemológicos, no sentido de auxiliar os alunos a transformar visões errôneas e distorcidas. O papel do professor é fundamental para reconhecer os obstáculos que os alunos trazem de suas vivências cotidianas e os que são construídos na própria sala de aula.
Reflexões sobre a formação inicial de professores de Física na UFMA
Authors: Vilela Paulo Sergio Jesus , Sousa Regina Célia , Aranha Carolina Pereira , Guerini Silvete Coradi
Published: August 2020

Este trabalho tem por objetivo refletir sobre aspectos da formação inicial de professores de Física a partir da perspectiva de estudantes do curso de Física Licenciatura da Universidade Federal do Maranhão. São apresentadas algumas problemáticas que interferem no processo de formação docente e contribuem para o elevado índice de evasão, assim como, se discute sobre o desenvolvimento da prática docente, nos primeiros anos do curso, analisando contribuições que algumas disciplinas e programas oferecem. Para embasar tais reflexões, além da análise do projeto pedagógico do curso, foi aplicado um questionário que coletou informações junto a estudantes, matriculados nas disciplinas Didática e Prática de Ensino I, ministradas no sexto e sétimo período, respectivamente. Os dados obtidos reafirmam prováveis motivos para a evasão do curso, entre eles, a falta de conhecimento de conceitos referentes a conteúdos da Educação Básica. Eles mostraram também, que estudantes que tiveram experiências na docência, se sentem estimulados a desenvolverem de forma mais consciente suas funções em sala de aula. As reflexões apresentadas aqui evidenciam a necessidade da realização de mais pesquisas referentes à formação inicial de professores de Física, bem como, a implantação de ações que promovam mudanças efetivas na organização de cursos de Licenciatura em Física.
O aplicativo plickers como instrumento de avaliação da aprendizagem no ensino de Física
Authors: Santos Patrik Marques dos , Nicot Yuri Expósito , Marques Ataiany dos Santos Veloso
Published: August 2020

O presente trabalho consiste numa pesquisa voltada ao processo de avaliação da aprendizagem da disciplina de Física II, o qual utilizou-se a tecnologia como recurso apoiante nessa prática. O objetivo foi avaliar quais contribuições a utilização do aplicativo Plickers promove no processo de avaliação da aprendizagem na disciplina de Física II do Ensino Médio. Fundamentou a práxis docente em autores que apresentam a avaliação como um processo construtivo e dinâmico no processo de ensino-aprendizagem e sua ascensão pela tecnologia. A prática apoiou-se numa pesquisa qualitativa participativa, dentro da Práxis como estrutura metodológica. O tratamento dos resultados gerado pelo aplicativo, fundamentados no processo de avaliação da aprendizagem dos autores citados, culminou em observações e reflexões sobre o processo de ensino-aprendizagem dos alunos e do professor, gerando mudanças significativas de postura do professor nas práticas avaliativas para disciplina de Física II do Ensino Médio e numa melhor compreensão da avaliação para o aprendizagem no processo de ensino-aprendizagem.
Na trilha da radiação: a produção de um jogo pedagógico a partir da prática como componente curricular
Authors: Santos Beatriz Cardoso dos , Faria Gabriela Peres de , Paiva Erick Henrique Siqueira , Guimarães Simone Sendin Moreira , Faria Fabrícia Paula de
Published: August 2020

O relato de experiência aqui apresentado se refere a uma atividade organizada no âmbito da disciplina de Biofísica em um curso de Licenciatura em Ciências Biológicas no contexto das Práticas como Componente Curricular (PCC).  Especificamente trata-se da descrição do processo de elaboração/criação do jogo Césio-137: Na trilha da radiação. O objetivo dessa produção foi criar alternativas para o ensino do conceito de "Radiações ionizantes". A construção do jogo foi orientada por duas grandes referências: a) jogos pedagógicos e b) história e filosofia da ciência. Consideramos que a PCC pode ser um momento ímpar para integração teoria-prática na formação de professores. Em relação ao jogo, o mesmo pode ser utilizado para apresentação de um novo conceito (radiação ionizante) contextualizado histórica e localmente (à luz do  acidente radiológico com Césio-137) e para realizar uma revisão e/ou avaliação sobre o conteúdo proposto.
O conceito de energia e suas manifestações: uma proposta de ensino investigativo para professores do ensino fundamental
Authors: De Jesus Souza Marques de Mendonça Amsterdam , Pereira Grazielle Rodrigues
Published: August 2020

O presente trabalho tem como objetivo analisar os resultados da aplicação de uma sequência de ensino investigativo sobre o conceito de energia, de forma interdisciplinar, junto aos professores do ensino fundamental. Buscou-se valorizar durante a atividade a sucessão temporal de descobertas científicas, o processo investigativo e os impactos socioambientais da grandeza energia para a vida humana e como essa sucessão de acontecimentos promoveu a nossa compreensão sobre o tema. Com vistas a alcançar tais objetivos, a estratégia de ensino foi aplicada junto a um grupo de professores participantes do curso de Formação Continuada de Ciências Naturais, do Instituto Federal do Rio de Janeiro. Para a coleta de dados foram aplicados questionários, diários de campo e rodas de conversa e colhido registros fotográficos, assim como os resultados obtidos foram analisados à luz da ferramenta de análise temática. Os resultados desse estudo, possibilitaram compreender as concepções dos participantes acerca do tema energia, bem como a realização de atividades baseadas no ensino investigativo favoreceu o processo de reflexão acerca dos fenômenos observados. Diante desses resultados, pode-se inferir que os docentes participantes reconheceram a importância do tema para os anos inicias, além de identificarem como uma possibilidade de articulação interdisciplinar.
Conceitos de Astronomia: Análise a partir de textos escritos pelos alunos
Authors: Martins Galvão Idmaura Calderaro , Assis Alice
Published: August 2020

Esta pesquisa foi realizada com alunos da primeira série do Ensino Médio de uma escola pública do Estado de São Paulo, em aulas de Física. Esses alunos participaram de uma atividade em que deveriam elaborar, em grupo, a escrita de uma história relativa ao tema “exploração espacial”, após realizarem, em sala de aula, a leitura de um livro paradidático associado à temática “Universo, Terra e Vida: constituintes do Universo” e, posteriormente, a discussão de alguns conceitos associados à Astronomia. Os dados, correspondentes a esses textos escritos, foram analisados de forma qualitativa, por meio da análise de conteúdo, buscando-se identificar de que forma os alunos usaram esses conceitos em suas histórias. A partir dos resultados, inferiu-se que o uso da escrita dos textos estimulou a criatividade e o raciocínio associados aos conceitos abordados em sala de aula, o que levou vários grupos de alunos a articularem esses conceitos ao contexto de suas histórias.
Electrically and Frequency-Tunable Printed Inverted-F Antenna with a Perturbed Parasitic Element
Authors: Choi Yoon-Seon , Hong Ji-Hun , Woo Jong-Myung
Published: August 2020

This study designed an electrically and frequency-tunable printed inverted-F antenna (PIFA) with a perturbed parasitic element between the antenna and the ground plane. The resonant frequency of the proposed antenna can be changed via the short- and open-circuit operation of the parasitic element. This operation is activated using an electrical switch, which in this case is a PIN diode with an inductor and a resistor. The antenna was designed on the basis of the principles of the perturbation method, which enables control over resonant frequencies through modifications to the volume of a metal cavity. Meandered gaps were incorporated into the parasitic element for the independent operation of each PIN diode switch. The size of the PIFA’s radiator is 4.8 × 10 mm2, and the tunable resonant frequency at the –10 dB bandwidth is 340 MHz (17.3%).
Performance Evaluation of a Modified SweepSAR Mode for Quad-Pol Application in SAR Systems
Authors: Lim Jung-Hwan , Lee Jae Wook , Lee Taek-Kyung , Lee Hyeon-Cheol , Lee Sang-Gyu , Ryu Sang-Burm , Yoon Seong-Sik
Published: August 2020

Efficient earth observation using spaceborne synthetic aperture radar (SAR) requires the analysis of high-resolution wide-swath (HRWS) systems, which have a fine resolution and a short revisit time through wide-area observation, and quadrature-polarimetric (quad-pol) systems, which can obtain a quad-pol image and have many applications. The operational method of SAR generally affects system performance involving the system parameters and antenna patterns, and thus analyzing HRWS quad-pol SAR systems is essential to the system design. In this paper, an extension of the modified SweepSAR technique to a quad-pol observation scenario is performed and a comparison to ScanSAR and conventional SweepSAR is provided for a simulated scenario. On the basis of the system requirements, we selected the optimal parameters and designed a reflector antenna suitable for a wide-swath quad-pol SAR system. As a result of comparing the wide-swath quad-pol SAR operation modes, the modified SweepSAR mode demonstrated advantages in terms of system performance, such as the ambiguity ratio and swath width, and reflector antenna design for a spaceborne SAR system.
Las Exposiciones de Museos: Un Espacio en Disputa por los Sentidos y Significados del Medio Ambiente y sus Problemas Socioambientales
Authors: Borroto Iván , Sammarco Yanina Micaela
Published: August 2020

El presente artículo se propone contribuir a las discusiones sobre el papel de museos frente a la crisis ambiental, mediante la discusión de la presentación del medio ambiente y de sus problemas socioambientales en las exposiciones. En esa dirección, se presenta inicialmente una revisión histórica sobre la constitución de los museos, a partir de algunas transformaciones experimentadas por sus colecciones. A continuación se desarrolla una discusión sobre la educación de los visitantes en el ámbito de las dimensiones tiempo, espacio y objeto. A partir de esa discusión se analizan las posibilidades comunicativas y educativas de las exposiciones. Por último, se presentan reflexiones sobre la exhibición del medio ambiente y sus problemas en las exposiciones de museos. A partir de este estudio, se percibe al museo público con posibilidades para la educación de la ciudadanía en cuestiones sociambientales. Por otro lado, se aprecia que en la práctica el tratamiento dado al medio ambiente y a sus problemas socioambientales no atiende a su naturaleza multifacética. Esta situación lleva a ubicar a museos públicos en una posición desfavorable frente a la posibilidad de contribuir al enfrentamiento de la crisis ambiental.
Assessing the efficacy of Canada's food guide and the barriers of use
Authors: Dibe Hana
Published: August 2020

The landscape of nutrition advice is vast and full of misinformation. A primary source of nutrition advice in Canada comes from the Canadian Food Guide, however, many questions remain regarding the reach and accessibility of the food guide. Specifically, is the population most likely to receive and use this information, the population that needs it the most? Are there barriers to following this guide that Health Canada has failed to address? Is there evidence supporting the efficacy of this food guide in populations at risk for nutrition misinformation or diet-related preventable diseases? This commentary reviews the past research regarding efficacy of previous food guides and highlights potential barriers preventing equal and accessible use of Canada’s Food Guide.
Untangling complexity as a health determinant
Authors: Petrie Samuel , Peters Paul
Published: August 2020

As the healthcare system has modernized, it has also become rich with complexity. This complexity continues to foster the creation of wicked problems that at first consideration appear inherently insoluble. To compound matters, policy-makers and decision-makers continue to view the healthcare system in a reductionistic, linear manner. This paper advocates that all stakeholders within the system (policy-makers, providers, and patients) become comfortable with complexity as a determinant of health, and offers tools for productively working with complexity, instead of trying to solve it. These tools include complexity heuristics, adjusting to an emergent decision-making paradigm, and easing the anxiety associated with ambiguity and paradox by becoming antifragile. By adopting these methods, the health determinant of complexity within the Canadian healthcare system can be effectively handled. This will lead to sustainable and scalable interventions, strong patient-partners in care, and efficient use of monetary and human resources.