bluuebunny/crossref_metadata_2025 huggingface dataset:
Disputas pela memória no ensaio argentino – o incômodo “Invierno”, de Juan José Saer
Authors: Checchia Cristiane
Published: January 2018

Publicado originalmente em 1991, El río sin orillas, do escritor argentino Juan José Saer (1937-2005), configura-se como uma obra bastante singular dentre a vasta produção do autor: ainda que admita não se tratar de obra “voluntariamente ficcional”, Saer recusa reiteradamente reconhecê-lo como ensaio, preferindo antes a denominação esquiva de “tratado imaginário” e descrevendo-o como um “híbrido sem gênero definido”. No presente artigo, propõe-se a análise do polêmico e incômodo capítulo “Invierno”, de El río sin orillas, no qual se acentuará uma linha bastante pronunciada que distanciará a voz do ensaísta da voz do escritor de ficções. Em “Invierno”, a história da formação da sociedade argentina, bem como a história recente do país são revistas a partir de um posicionamento específico, pelo qual o autor se insere polemicamente no campo político argentino, inclusive às custas da verve literária do texto que predomina no restante do livro. A leitura de “Invierno” será contrastada com alguns relatos ficcionais de Saer, de modo a evidenciar-se a diferença de tratamentos do topos da violência e da política na ficção e no ensaio. Espera-se, por um lado, que este trabalho permita uma aproximação crítica a questões nucleares do projeto estético saeriano, mas também, e por outro lado, que torne possível uma reflexão mais ampla acerca das tensões envolvidas nas disputas pela memória do passado recente argentino e da forma como o ensaio é convocado a participar desse conflito.
Éloge de la traduction: compliquer l'universel, de Barbara Cassin: Fayard, 2016
Authors: Petry Simone Christina
Published: January 2018

Resenha do livro: Éloge de la traduction: compliquer l'universel. Paris: Fayard, 2016. 247 p.
Faktor Yang Mempengaruhi Kepatuhan Penulisan Resep Sesuai Formularium
Authors: Mahfudhoh Siti , Rohmah Thinni Nurul
Published: January 2018

ABSTRACT Based on data from January - April 2014 found that obedience of prescription writing based on formularium in Outpatient Installation of Islam Jemursari Hospital only amounted to 87.9%. The purpose of this study was to analyze the factors that affect the obedience of prescription writing based on formularium. This study was an observational analitic cross sectional study. Data analysis using Spearman correlation test (α = 0.05). Obedience of prescription writing based on formularium mostly in the category of obedience (37.8%). Spearman correlation test showed no correlation between the status of the location (p = 0.166), the legitimacy of authority figures (p = 0.841), and the status of an authority figure (p=0,549) with the obedience of prescription writing based on formularium (p = 0.166). There was a significant relationship between personal responsibility (p = 0.005), peer support (p = 0.007), and the proximity of authority figures (p = 0.002) with obedience of prescription writing based on formularium. The conclusion that can be drawn is appropriate prescribing formulary can be improved by providing incentives and sanctions of the pieces and there are electronic formulary list. Keywords: formulary, obedience, prescription
Analisis Penilaian Dan Harapan Pasien Poli Gigi Dan Mulut Dengan Metode Spider Web Berdasarkan Dimensi Mutu Dabholkar
Authors: Permatasari Mustika Dyah , Haksama Setya
Published: January 2018

ABSTRACT There are many factors that determine health care service quality. One of them is the internal factor. This research was done to arrange recomendation increasingdental polyclinic utilization based on Dabholkar quality dimention.This was an observational study with cross sectional design of the 70 respondents who are representing dental polyclinic’s patient in a month. Data were collected by questionnaires distributed to respondents to identify the respondent’s assessment and expectation about physical aspects dimension, reliability dimension, personal interaction dimension, problem solving dimension, and policy dimension of dental polyclinic service quality. The conformity between assessment and expectation of respondentson service quality was analyzed based on Dabholkar quality dimension by using spider web. The results showed that most dimensions have been suitable about reliability dimension, personal interaction dimension and problem solving dimension. While the conformity of physical aspects dimension and policy dimension are not quite good. The conclusions showed that physical aspects dimension and policy dimension are the top priority, while reliability dimension, personal interaction dimension and problem solving dimensionneed repairement are still need to be maintained.  Keywords: Dabholkar quality dimension, physical aspects dimension, policy                     dimension
Kepatuhan Pasien Rawat Inap Diet Diabetes Mellitus Berdasarkan Teori Kepatuhan Niven
Authors: Ilmah Farida , Rochmah Thinni Nurul
Published: January 2018

ABSTRACT Diabetes Mellitus is one of disease related to nutrition. Diabetes Mellitusinpatient’s food waste plate is one of the manifestation of noncompliance to the diet program that have been recommended by health workers. This study analyzed the influence of noncompliance inpatients with Diabetes Mellitus diet in dr. M. Soewandhie Surabaya based on the theory compliance by Niven. This was analytic observasionalstudy with cross sectional design. This study used32 samples. Data were analyzed using linear regression test. The results showed that 64.7% of respondents who have a good attitude did notcomply to the diet, 85,7% of respondentswho noncompliance to the diet has very good belief. Meanwhile, 50% of respondents who di not understand the instruction from nutritionists belonging to noncompliance. Then 85.7% of respondents felt lack of support from their family classified as noncompliance category. While, 75% of respondents who feel very good quality interaction with nutritionists belonging to noncompliance respondent. While, 66,7% respondents who got enough support from nutritioniststned to comply the diet. The study showed that official support (nutritionists) influence the patient compliance (ρ = 0,000) with a value of B = -6. Counseling to inpatients Diabetes Mellitus diet every daycould change the compliance patients. Keywords: compliancetheory, Diabetes  mellitus diet, food waste plate, health                 worker support, niven
Pengaruh Penerapan Prinsip Leadership, Employee Involvement, dan Continuous Improvement terhadap Kepuasan Kerja Karyawan
Authors: Prasanti Aderia Putri , Damayanti Nyoman Anita
Published: January 2018

ABSTRACT Job satisfaction rate of Rumah Sakit Mata Undaan Surabaya (RSMU)’s employees increasedfrom 76,92% to 78,92% in 2012-2013. Unfortunately, in 2014 this rate decreased to 74,91%. The target set by management is 80%. Therefore, job satisfaction rate of RSMU’s employees has not reached the target. The aim of this study is to analyze the influence of leadership, employee involvement, and continuous improvement principle implementationtowards the job satisfaction of RSMU’s employees. This study used observational method with cross sectional design. The data was obtained through questionnaire with simple random sampling involving 90 employees as the sample of the research. The next step is analyzing the data analytically by using logistic regression test univariate (α=0,05) to examine the influence of leadership, employee involvement, and continuous improvement principle implementation towards the employee’s job satisfaction. The test result indicates that there are influences of two principles implementation towards the employee’s job satisfaction. Those principles, on the one hand, are leadership (sig=0,002) and continuous improvement (sig=0,006). On the other hand, the implementation of employee involvement does not affect the job satisfaction.Keywords :Employee job satisfaction, leadership, employee involvement, continuous improvement
Hubungan Bauran Pemasaran Jasa Pelayanan Keperawatan dengan Loyalitas Pasien
Authors: Rita Nova
Published: January 2018

ABSTRACTHigh public interest to go abroad for treatment need to be a particular concern for hospitals in the country. The hospital is not only able to create berkelualitas services but also need to create loyalty to the patient. Loyalty will be created if any implementation of nursing services mix well done. This study aims to determine the relationship of nursing mix shipping services with patient loyalty. This type of survey research with cross sectional analytic study with a sample of 68 people. The way to get the sample with stratified proportional is random sampling. The research result was analyzed by using chi square and logistic regression test. The result of research showed that there is a significant relationship between the marketing mix with nursing service ( product, place, price, promotion, people, and process, as well as physical evidence) with the patient loyalty in which score p > 0,05. A conclusion of the research is simplified that there is a relationship between the marketing mix with hospital service for the patient loyalty. The relationship could be seen at people variable and health insurance with patient loyalty. The development division for service and marketing at hospital is necessary to apply the specific cost as to promote the old patient and the qualified service of nursing. The other major focus want to develop the healthy service of nursing treatment, also provide the patients’ satisfaction, thus  it make patients’ loyalty on the installation of hospitality of Ambun Pag.Keywords: mixed, marketing, loyalty, patients
Beban Kerja Obyektif Tenaga Perawat di Pelayanan Rawat Inap Rumah Sakit
Authors: Romadhoni Rohmat Dwi , Pudjirahardjo Widodo J.
Published: January 2018

Inpatient services at the X Hospital consists of Intensive Care Units and Inpatient Units. In 2014, a nurse  at the unit as a whole experienced a shortfall of 66.67% from 9 rooms there. This shortage triggered theincreasing of nurse workload. This study aimed to find out the objective workload on nurses in Intensive Care Units and Inpatient Units. This research is quantitative descriptive with cross-sectional design. The sample used is total sampling, as many as 174 nurses. Data obtained using activity sheets time and motion study indirectly (self-assessment). Results from this study show the objective workload in the Intensive Care Unit on the morningshift have a heavy workload category, afternoon shift and the night shift has a moderate workload category, while at Inpatient Unit on the morning shift and afternoon shift has a heavy workload category, and shift night has amoderate workload category. The conclusion of this study is objective workload in the Intensive Care Unit has a moderate workload category, while the objective workload in the Inpatient Unit has a heavy workload category.Keywords: nurse,objective workload, time and motion study
Pengelolaan Sediaan Obat Pada Logistik Farmasi Rumah Sakit Umum Tipe B di Jawa Timur
Authors: Febreani Stella Herliantine , Chalidyanto Djazuly
Published: January 2018

Inventory control of drugs in hospital which are not done properly can cause stockout or stagnant of supplies. Based of data processing of the drug at Siti Khodijah Sepanjang Hospital experienced stagnant amount 38,9% and stockout amount 29,3% during period January-September 2015. The objectives of the study were to analysis inventory control of drug in logistic pharmacy Siti Khodijah Sepanjang Hospital. This research was a descriptive research with cross sectional design by observation and interviews. Indepth interviews were carried out to get more detailed information about the variables examined. Activity of planning, procurement, distribution, and storage are performed not effective enough so led to stagnant and stockout drug. Also evaluation that has running was not adequate because only looks about financial audit. The conclusion that can be drawn is logistic management system has not run effectively so that the occurrence so stagnant and stockout drug.Keywords: drug stagnant and stockout, hospital, inventory control, logistic management
Penerapan Theory of Constraint pada Kepuasan Kerja Karyawan Rumah Sakit Mata Undaan Surabaya
Authors: Larasati Selviana Putri , Haksama Setya
Published: January 2018

The level of job satisfaction in Undaan Eye Hospital had fluctuating trend since 2012 to 2015. The level of job satisfaction in 2015 was 77,80% that had not reached the target of 80%. The aim of this study was to analize job satisfaction using theory of constraint in Undaan Eye Hospital. This study was an cross sectional observational study. The sample size of this study were 57 employee which were selected using simple random sampling technique (α = 0.05).Health insurance was found as constraint in organizational factor with constraint value of 129. Not only helath insurrance but also career development was found as constraint in organizational factor with constraint value of 132. In the other hand, atmosphere of workplace was found as constraint in work environment with caonstraint value of 141. It can be concluded that efforts should be made to improve employee job satisfaction in Undaan Eye Hospital is to pay attention to health insurance, career development, and workplace atmosphere.Keywords:constraint, job satisfaction, theory of constraint
Analisis Pemenuhan Indikator Pembayaran Kapitasi pada Fasilitas Kesehatan Tingkat Pertama di Surabaya
Authors: Widaty Delvia
Published: January 2018

Lack of patient visits to FKTP causes capitation not being optimally utilized. The purpose of this research is to analyze the causes of the unfullfilled capitation payment indicators based on fulfillment of service commitment at FKTP. The type of research used is observational with cross sectional design. Approach in the research is quantitative and qualitative. The research used total sampling, where population is secondary data covering result of indicator achievement from 62 Puskesmas, 31 DPP, and 97 Klinik Pratama in Surabaya. This research concluded that indicator of AK and RPPB at FKTP still not fulfill target of safe zone. AK can be caused by the lack of participants’ knowledge of FKTP services, limited resources, and BPJS Kesehatan online application that sometimes have interruptions. FKTP needs to provide promotions and education to participants’, add resources and provide training to staff, advocate with health offices, and cooperation with other parties to help provide facilities. Whereas the target indicator of RPPB has not been achieved due to lack of socialization of Prolanic. FKTP expected to be able to run activities that are promotive and preventive in groups. Keywords: capitation, capitation payment indicators based on fulfillment of service commitment, FKTP
Analisis Pelaksanaan Sistem Rujukan Berjenjang Bagi Peserta JKN di Puskesmas X Kota Surabaya
Authors: Ratnasari Dwi
Published: January 2018

The era of National Health Security (NHS) enacted tiered referral system start in primary health care. High number of referrals at Public Health Center (PHC) X indicates that the implementation of referral system did not go well. The objectives of this study is to confirm implementation of refferal system in PHC in the era NHS based on the regulations and policies. This was descriptive observational research and cross sectional design with implementation research method. This research used triangulation to get deep information toward referral documents include referral data, registration book, medical records, referral letter, interview with refferal officer, and observation without intervention. This research was conducted at PHC X Surabaya on the Februari-March 2017. The results showed implementation of refferal system has appropriate with the regulations and the guidelines. The implementation has appropriate with 7 section on The Regulation of Health Minister No.1 of 2012. The implementation has appropriate with Guidelines of National Health Refferal include requirement to refer patient, refferal clinical procedure, and refferal administrative procedure, however there is not appropriate implementation: informed consent, contact to refferal destination healthcare, and print out of refferal paper. Recommendation for PHC is to do informed consent and print refferal letters 2 copies.Keywords: national health security, public health center, refferal system
Pengaruh Kepuasan Kerja dan Komitmen Organisasi Terhadap Intention to Leave di Rumah Sakit Pura Raharja Surabaya
Authors: Rahmat Putra Muhammad Faris
Published: January 2018

Turnover can be detrimented to the organization both in terms of cost, resources, and motivation of employees. The purpose is to determine the relationship variables on job satisfaction and commitment with the intention to leave. The method is an observational study with cross-sectional study. Samples from this study are employees Pura Raharja Hospital Surabaya who meet the criteria that respondents who are still within reach of researchers and respondents are willing to fill out a questionnaire study. Samples were calculated using simple random sampling and obtained by 50 respondents and the value of α = 0.05. The results of linear regression showed that the intention to leave the job is job satisfaction, career development job satisfaction and organizational commitment. The value of significance job satisfaction that is equal to 0,004 jobs, job satisfaction significant value that is equal to 0,04, career development and organizational commitment of significant value that is equal to 0.027. The variables that do not affect the intention to leave are a co-worker job satisfaction, job satisfaction wages, job satisfaction supervision and work commitments. The conclusion of this study is Job satisfaction affects the intention to leave and also commitments affect the intention to leave. Keywords: commitment, intention to leave, job satisfaction, turnover
College Students’ Stress Coping Behaviors and Perception of Stress-Effects Holistically
Authors: Dexter Lauren Rose , Huff Katie , Rudecki Mollie , Abraham Sam
Published: January 2018

Objective: The purpose of the current study was to determine college students’ stress coping behaviors and perception of stress-effects holistically (emotionally, mentally, and physically).Participants: The current study was conducted using a convenience sample of 120 students in a Midwestern Christian college with a student population of about 2000. Participants were mostly from the education, nursing, and ministry departments.Method: A quantitative, cross-sectional, with a descriptive survey design was most suitable for this study.Results: Students deal with stressors in positive and negative ways. Positive ways included exercise, depending more on faith, and telling themselves that everything will be “Okay.” Negative ways included eating more, sleeping less, increased use of the Internet and more procrastination.Conclusions: College students are aware of constructive ways to cope with stress; however, these techniques are rarely used.
The Role of Social Media in Providing Crisis Information in China: A Critical Evaluation of the Tianjin Fire Incident
Authors: Li Xiangfei , Boersma Kees
Published: January 2018

This paper focusses on the information asymmetry in crisis news after a serious incident in Tianjin, China, in 2015. The incident caused enormous damage and resulted in societal unrest because of the lack of reliable information from the formal media channels. Social media — micro blogs — played a major role in reporting on crisis situations. We divided netizens (i.e., the citizens of the net) into high and low types according to their information-critical level to the crisis news. The data shows information deterioration on the crisis news, related to the netizens’ information-critical level. For the traditional media there is the opportunity to use information quality distortion to make more marginal profits. This is possible only if the citizens’ information stays under a certain quality level. The result is overprovision of low quality news and high quality news driven out of the market, whereupon adverse selection (i.e., a lack of symmetric information) appears. However, by adopting a process view, we found self-correcting mechanism (i.e., dying out of rumors) of the social media communities in China. We provided a agent-base model and simulation to show that the more media exist in the market, the faster speed of the information deterioration, but also the capacity to ‘discuss’ rumors.
Acute onset shortness of breath in labour: haemothorax secondary to pulmonary arteriovenous malformation
Authors: Joy Paula , Gouldson Sarah , Jordan Lesley , Weale Nicola
Published: January 2018

We report the case of a 31‐year‐old female presenting with haemothorax secondary to rupture of pulmonary arteriovenous malformation following induction of labour. This caused fetal compromise that necessitated immediate delivery. Emergency embolisation was performed after inter‐hospital transfer to a regional centre with interventional radiology facilities. The postoperative course was complicated by large volume pulmonary emboli and persistent infection which required video assisted thorascopic surgery.
Difficult positive pressure ventilation in an adult with a tracheostomy
Authors: Li Li , Dorsey David , Meyer Tanya , Bhananker Sanjay
Published: January 2018

Tracheomalacia and tracheobronchomalacia are rare disorders of a weakened airway that predispose patients to excessive airway compression, typically during expiration. Recommended anaesthetic management includes continuous positive airways pressure or positive end‐expiratory pressure in order to maintain airway calibre. We present the case of a 57‐year‐old female with Weill‐Marchesani syndrome, tracheobronchomalacia, and a permanent tracheostomy in whom we experienced difficulty maintaining adequate ventilation, oxygenation, and tidal volumes with positive pressure ventilation during anaesthetic induction, which improved with restoration of spontaneous breathing. We liken this to the physiology of an anterior mediastinal mass and recommend a similar anaesthetic approach.
Timing of human-induced climate change emergence from internal climate variability for hydrological impact studies
Authors: Zhuan Mei-Jia , Chen Jie , Shen Ming-Xi , Xu Chong-Yu , Chen Hua , Xiong Li-Hua
Published: January 2018

This study proposes a method to estimate the timing of human-induced climate change (HICC) emergence from internal climate variability (ICV) for hydrological impact studies based on climate model ensembles. Specifically, ICV is defined as the inter-member difference in a multi-member ensemble of a climate model in which human-induced climate trends have been removed through a detrending method. HICC is defined as the mean of multiple climate models. The intersection between HICC and ICV curves is defined as the time of emergence (ToE) of HICC from ICV. A case study of the Hanjiang River watershed in China shows that the temperature change has already emerged from ICV during the last century. However, the precipitation change will be masked by ICV up to the middle of this century. With the joint contributions of temperature and precipitation, the ToE of streamflow occurs about one decade later than that of precipitation. This implies that consideration for water resource vulnerability to climate should be more concerned with adaptation to ICV in the near-term climate (present through mid-century), and with HICC in the long-term future, thus allowing for more robust adaptation strategies to water transfer projects in China.
Conjunctive management of surface and groundwater in transboundary watercourses: a first assessment
Authors: Lautze Jonathan , Holmatov Bunyod , Saruchera Davison , Villholth Karen G.
Published: January 2018

Cooperative management of transboundary river basins is widely recognized as important. Emphasis on joint management of shared aquifers has also grown in recent years. Perhaps surprisingly, despite abundant focus on transboundary surface water and growing focus on shared groundwater, there is scant focus on their intersection. To address this knowledge limitation, this article reviews experiences in transboundary water treaties oriented toward different water sources, in order to: (i) understand how transboundary water institutions vary according to the water source to which they are oriented, (ii) gauge the nature and strength of conjunctive transboundary water management treaties, and (iii) identify ways to enhance conjunctive water management in transboundary contexts. The results reveal the existence of more than 50 treaties that make mention of both water sources. Nonetheless, only eight treaties devote ‘substantive’ focus to both surface and groundwater. Review of treaty contents reveals that their focus is on ‘softer’ issues related to institutional development. Moving forward, the reality that the evolution of conjunctive treaties is relatively nascent, and that scope of such treaties is still limited to institutional issues, may indicate large untapped potential – it may be time to outline pathways toward practical implementation of conjunctive water management in transboundary contexts.
Improved UV/O3 method for measuring the chemical oxygen demand
Authors: Le Gaoyang , Yang Huizhong , Yu Xiaodong
Published: January 2018

We improved the ultraviolet (UV)/O3-based method for measuring chemical oxygen demand (COD) in water. An on-line COD monitoring device was developed and the UV/O3 method was used to oxidize sample solutions. A model was established by using support vector machines (SVM) algorithm to estimate dissolved oxygen and CO2 in solutions. Based on the measured data by each sensor during the oxidation process and the estimated dissolved oxygen and CO2, the UV/O3-based COD test accuracy was improved. This approach overcomes many problems associated with the conventional COD determination techniques such as long analysis time, consumption of expensive and toxic reagents, and production of secondary toxic waste. The effect of important parameters on the measurement of COD was systematically investigated. The improved method was successfully applied to determine the COD of real samples from environmental water. Compared with the standard dichromate method, our UV/O3-based COD test method is more effective. The assay time of 10–15 min/sample can be readily achieved. A practical detection limit of 0.89 mg/L COD with a linear range of 1–300 mg/L was achieved under the normal conditions.
Multi-Pharmacophore Modeling of Caspase-3 Inhibitors using Crystal, Dock and Flexible Conformation Schemes
Authors: Kumar Sivakumar Prasanth , Jha Prakash Chandra
Published: January 2018

Aim and Objective:

Numerous caspase-3 drug discovery projects were found to have relied
on single receptor as the template to recognize most promising small molecule candidates using
docking approach. Alternatively, some researchers were contingent upon ligand-based alignment to
build up an empirical relationship between ligand functional groups and caspase-3 inhibitory activity
quantitatively. To connect both caspase-3 receptor details and its inhibitors chemical functionalities, this
study was undertaken to develop receptor- and ligand-pharmacophore models based on different
conformational schemes.

Material and Methods:

A multi-pharmacophore modeling strategy is carried out based on three
conformational schemes of pharmacophore hypothesis generation to screen caspase-3 inhibitors from
database. The schemes include (i) flexible (conformations unrestricted or flexible during
pharmacophore mapping), (ii) dock (conformations obtained using FlexX docking method) and (iii)
crystal (extracted from multiple caspase-3-ligand complexes from PDB repository) conformations of
query ligands. The pharmacophore models developed using these conformational schemes were then
used to identify probable caspase-3 inhibitors from ZINC database.

Results:

We noticed better sensitivity with good specificity measures returned by candidate
pharmacophore hypotheses across each conformation type and recognized crucial pharmacophore
features that enable caspase-3 binding. Pharmacophore modeling based on flexible conformational
scheme indicated that the crystal structure 3KJF (AAAADH) is the best receptor structure to perform
receptor-based pharmacophore screening of caspase-3 inhibitors. When multiple crystal structures were
included, the hypothesis (HAAA) is more generalized. Superimposition of multiple co-crystal ligands
from various caspase-3 PDB entries in crystallographic binding mode revealed similar hypothesis
(HAAA). Further, FlexX-guided dock conformations of validation dataset showed that the crystal
structure 1RE1 is the best-suited for dock-based pharmacophore models. Database screening using
these pharmacophore hypotheses identified N'-[6-(benzimidazol-1-yl)-5-nitro-pyrimidin-4-yl]-4
methylbenzenesulfonohydrazide and 2-nitro-N'-[5-nitro-6-[N'-(p-tolylsulfonyl)hydrazino]pyrimidin-4-
yl]benzohydrazide as the probable caspase-3 inhibitors.

Conclusion:

N'-[6-(benzimidazol-1-yl)-5-nitro-pyrimidin-4-yl]-4 methylbenzenesulfonohydrazide and
2-nitro-N'-[5-nitro-6-[N'-(p-tolylsulfonyl)hydrazino]pyrimidin-4-yl]benzohydrazide may be tested for
caspase-3 inhibition. We believe that potential caspase-3 inhibitors can be recognized efficiently by
adapting multi-pharmacophore models in database screening.
Hadoop-MCC: Efficient Multiple Compound Comparison Algorithm Using Hadoop
Authors: Hua Guan-Jie , Hung Che-Lun , Tang Chuan Yi
Published: January 2018

Aim and Objective:

In the past decade, the drug design technologies have been improved
enormously. The computer-aided drug design (CADD) has played an important role in analysis and
prediction in drug development, which makes the procedure more economical and efficient.
However, computation with big data, such as ZINC containing more than 60 million compounds data
and GDB-13 with more than 930 million small molecules, is a noticeable issue of time-consuming
problem. Therefore, we propose a novel heterogeneous high performance computing method, named
as Hadoop-MCC, integrating Hadoop and GPU, to copy with big chemical structure data efficiently.

Materials and Methods:

Hadoop-MCC gains the high availability and fault tolerance from Hadoop,
as Hadoop is used to scatter input data to GPU devices and gather the results from GPU devices.
Hadoop framework adopts mapper/reducer computation model. In the proposed method, mappers
response for fetching SMILES data segments and perform LINGO method on GPU, then reducers
collect all comparison results produced by mappers. Due to the high availability of Hadoop, all of
LINGO computational jobs on mappers can be completed, even if some of the mappers encounter
problems.

Results:

A comparison of LINGO is performed on each the GPU device in parallel. According to the
experimental results, the proposed method on multiple GPU devices can achieve better
computational performance than the CUDA-MCC on a single GPU device.

Conclusion:

Hadoop-MCC is able to achieve scalability, high availability, and fault tolerance
granted by Hadoop, and high performance as well by integrating computational power of both of
Hadoop and GPU. It has been shown that using the heterogeneous architecture as Hadoop-MCC
effectively can enhance better computational performance than on a single GPU device.
Towards Prevention of Ovarian Cancer
Authors: Ali Aus Tariq
Published: January 2018

Ovarian cancer is the leading cause of death of all gynaecological cancers. To date, there
is no reliable, specific screening procedure for detecting ovarian cancer. The risk factors of ovarian
cancer include modifiable and non-modifiable factors. The main goal of the ovarian cancer prevention
program is to significantly reduce the risk of development of ovarian cancer and other cancers
such as breast and/or peritoneal cancer. The application of non-surgical preventive approaches such
as oral contraceptives, parity and breastfeeding has been shown to be highly protective against ovarian
cancer development. Targeting inflammation has been also reported to be associated with a protective
trend against ovarian cancer and can be achieved through either non-steroidal antiinflammatory
drugs (NSAIDs) such as aspirin or lifestyle modifications or both. Lifestyle modification
that includes regular exercise, healthy diet supplemented with anti-oxidants and antiinflammatory
elements reduces the risk of the disease even further. Surgical protective approaches
include; tubal ligation, hysterectomy and prophylactic bilateral salpingo-oophorectomy and the former
is the most effective approach to protect against ovarian cancer. A better understanding of the
risk factors of ovarian cancer and the current approaches to prevent it may increase the awareness
and help decrease the incidence of ovarian cancer, increase the five-year survival rate and decrease
the mortality rate significantly in the general population especially among those at high risk for
ovarian cancer. This review is an attempt to outline a potential program of ovarian cancer prevention
and the potential challenges.
Aortic Stenosis, Aortic Regurgitation and Arterial Hypertension
Authors: Katsi V. , Georgiopoulos G. , Oikonomou D. , Aggeli C. , Grassos C. , Papadopoulos D.P. , Thomopoulos C. , Marketou M. , Dimitriadis K. , Toutouzas K. , Nihoyannopoulos P. , Tsioufis C. , Tousoulis D.
Published: January 2018

Background: Hypertension (HT) is an important risk factor for cardiovascular disease and
might precipitate pathology of the aortic valve.

Objective: To investigate the association of HT with aortic dysfunction (including both aortic regurgitation
and stenosis) and the impact of antihypertensive treatment on the natural course of underlying aortic
disease.

Methods: We performed a systematic review of the literature for all relevant articles assessing the
correlation between HT and phenotype of aortic disease.

Results: Co-existence of HT with aortic stenosis and aortic regurgitation is highly prevalent in hypertensive
patients and predicts a worse prognosis. Certain antihypertensive agents may improve haemodynamic
parameters (aortic jet velocity, aortic regurgitation volume) and remodeling of the left ventricle,
but there is no strong evidence of benefit regarding clinical outcomes. Renin-angiotensin system inhibitors,
among other vasodilators, are well-tolerated in aortic stenosis.

Conclusion: Several lines of evidence support a detrimental association between HT and aortic valve
disease. Therefore, HT should be promptly treated in aortic valvulopathy. Despite conventional wisdom,
specific vasodilators can be used with caution in aortic stenosis.
Integrating Morphological Edge Detection and Mutual Information for Nonrigid Registration of Medical Images
Authors: Aggarwal Vivek , Gupta Anupama
Published: January 2018

Background:

Medical images are widely used within healthcare and medical research.
There is an increased interest in precisely correlating information in these images through registration
techniques for investigative and therapeutic purposes. This work proposes and evaluates an
improved measure function for registration of carotid ultrasound and magnetic resonance images
(MRI) taken at different times.

Methods:

To achieve this, a morphological edge detection operator has been designed to extract
the vital edge information from images which is integrated with the Mutual Information (MI) to
carry out the registration process. The improved performance of proposed registration measure
function is demonstrated using four quality metrics: Correlation Coefficient (CC), Structural Similarity
Index (SSIM), Visual Information Fidelity (VIF) and Gradient Magnitude Similarity Deviation
(GMSD). The qualitative validation has also been done through visual inspection of the registered
image pairs by clinical radiologists.

Results:

The experimental results showed that the proposed method outperformed the existing
method (based on integrated MI and standard edge detection) for both ultrasound and MR images
in terms of CC by about 4.67%, SSIM by 3.21%, VIF by 18.5%, and decreased GMSD by 37.01%.
Whereas, in comparison to the standard MI based method, the proposed method has increased CC
by 16.29%, SSIM by 16.13%, VIF by 52.56% and decreased GMSD by 66.06%, approximately.

Conclusion:

Thus, the proposed method improves the registration accuracy when the original images
are corrupted by noise, have low intensity values or missing data.
Magnesium Perchlorate Catalyzed Phospha-Michael Addition of Dialkyl Phosphite to Chalcone
Authors: Sahu Adarsh , Mishra Shweta , Gajbhiye Asmita , Agrawal Ram Kishore
Published: January 2018

Aim and Objective: Phosphonate possesses a broad range of applications ranging from agrochemistry
to medicines. Because of the synthetic and biological importance of phosphonate, their chemistry has
stimulated an increasing interest. Hence we developed an efficient and eco-friendly Mg(ClO4)2 catalyzed one
pot, solvent free synthesis of phosphonate derivatives of chalcones.

Materials and Methods:

Magnesium perchlorate phosphonate derivatives of chalcones were synthesized. The
reactions were executed at room temperature in the presence of Anhydrous Magnesium perchlorate Anhy.
Mg(ClO4)2 under solvent free condition, affording high yield of the product. The cardinal significance of the
method lies in its uncomplicated and eco- friendly experimental conditions.

Results:

The PMA method for P-C bond formation, using dialkyl phosphite with chalcone, was performed in
the presence of Anhydrous Magnesium perchlorate under solvent free condition. Despite the solvent free condition,
the methodology is efficient since it is required only in catalytic amount of Anhy. Mg(ClO4)2 in one pot
reaction. Results demonstrated that the catalytic PMA of dimethyl phosphite, diethyl phosphite, diisopropyl
phosphite and dibutyl phosphite with chalcone generates desired products with a percentage yield of 60-80%.

Conclusion:

We have developed a new efficient PMA method for P-C bond formation, using dialkyl phosphite
with α,β-unsaturated ketone i.e. chalcone. To the best of our knowledge, Anhy. Mg(ClO4)2 catalyzed phosphamicheal
addition of dialkyl phosphite with chalcones was found to be a new and efficient method for various
biological applications.
Literasi Media Sosial Humas Pemerintah Daerah
Authors: Putra Novian Anata
Published: January 2018

Nowadays, the government is trying to fight against hoax. One of them, PresidentJoko Widodo instructed to improve the function of government public relations andinformation managers to ward off hoaxes spread quickly in social media. However, itwill work if government public relations officers have adequate social media literacyskills. Social media literacy is considered the basis for understanding the characteristicsof new media. The aim of this research is to examine the level of social meda literacyamong local government public relations at present. Quantitative approach with surveymethod will be used in this research. The study was conducted in eight local governmentsthat have held anti-hoax declarations. The eight local governments are: Semarangregency, Semarang city, Wonosobo regency, Solo city, Banyumas regency, Bloraregency, Yogyakarta city and Province of Bali. Based on the research analysis, it can beconcluded that the managers of social media public relations of local governments whohave held anti-hoax declaration are already have enough social media literacy. The localgovernment needs to increase knowledge and skills that are technical about new mediaand social media in order to optimize the function and the role of local governmentpublic relations in the effort to ward off hoaxes. While the hardest part of social medialiteracy, which always involves the criticality literacy media, most of local governmentpublic relations have already master it. Pemeritah saat ini berusaha melawan berita-berita hoax. Salah satunya, Presiden Joko Widodo menginstruksikan untuk meningkatkan fungsi humas pemerintah dan pengelola informasi untuk menangkal hoax yang tersebar cepat di media sosial. Namun, hal itu akan berhasil jika para petugas humas pemerintah mempunyai kecakapan literasi media sosial yang memadai. Literasi media sosial dianggap sebagai dasar memahami karakteristik media baru. Penelitian ini akan melihat sejauh mana tingkat literasi media sosial di kalangan humas pemerintah daerah saat ini. Penelitian menggunakan pendekatan kuantitatif dengan metode survei. Penelitian dilakukan di delapan pemerintah daerah yang telah menggelar deklarasi anti hoax, yakni Kota Semarang, Kabupaten Semarang, Kabupaten Wonosobo, Kota Solo, Kabupaten Banyumas, Kabupaten Blora, Kota Yogyakarta, dan Provinsi Bali. Dengan tidak adanya nilai rendah, maka dapat disimpulkan bahwa para pengelola media sosial humas pemerintah daerah yang telah menggelar deklarasi anti hoax telah memiliki literasi media sosial yang cukup. Untuk mengoptimalkan fungsi dan peran humas pemerintah daerah dalam usaha menangkal hoax hanya perlu meningkatkan pengetahuan dan ketrampilan yang sifatnya teknis tentang media baru dan media sosial. Sedangkan bagian tersulit dari literasi media sosial, yaitu selalu melibatkan tingkat kekritisan para pegawai humas pemerintah daerah dalam aktifitas media sosial, telah banyak yang menguasainya.
Expressions and Stylistic Trends of Homeowners in Terrace Housing
Authors: Saruwono Masran , Mohd Rashid Abdurrahman , Omar Erdayu Osâ€™hara
Published: January 2018

This study attempts to discover the alteration trends of house renovations focusing on terrace houses. Thirty renovated houses located in Shah Alam were identified, visually observed and analysed. The houses were photographed and the sorting process was carried out for analysis at the studio. The results show the altered houses could be classified into four established styles namely; traditional, modern, post-modern and 'others'. There is no one particular style of the facade that was significantly more popular among them. Something that can be learnt from this study is that people are expressive of their stylistic preferences even under the constraints of the typically narrow-frontage terrace houses.
Betting on Elections: History, Law and Policy
Authors: Orr Graeme
Published: January 2018

Betting on elections has a long history, despite periods in which wagers were unenforceable and even criminalised. In recent years, significant online markets have emerged, driven by the bookmaking industry in those jurisdictions which license betting on politics. These markets treat election wagers as a form of sports betting. This article examines the provenance and regulation of election betting in the common law. It charts this from early case law holding wagers involving electors to be void (as tainting voting decisions) through criminal prohibitions, some of which are still on the statute books (since wagers could disguise electoral bribes) and onto contemporary regimes for licensing electoral bookmaking.

Normative arguments about election betting and the law include the liberal harm principle, the precautionary principle and the concept of commodification. The article concludes that friendly wagers should be permitted, to allow partisans to intensify the ritual experience of elections. But bets involving politicians should be outlawed, and the industrialisation of election betting should not be encouraged given the risk of commodifying the values underlying electoral democracy.
Introducing Safe Access to Sensitive Data at the University of Bristol
Authors: Hiom Debra , Gray Stephen , Steer Damian , Merrett Kirsty , Snow Kellie , Beckles Zosia
Published: January 2018

The economic and societal benefits of making research data available for reuse and verification are now widely understood and accepted. However, there are some research studies, particularly those involving human participants, which face particular challenges in making their data openly available due to the sensitivities of the data. Despite its potential value to society this material is invariably kept locked away due to concerns over its inappropriate disclosure. The University of Bristolâ€™s Research Data Service has developed the institutional infrastructure, including policies and procedures, required to safely grant access to sensitive research data in a way that is transparent, secure, sustainable and crucially, replicable by other institutions.
This paper looks at the background and challenges faced by the institution in dealing with sensitive data, outlines the approach taken and some of the outstanding issues to be tackled.
This paper looks at the background and challenges faced by the institution in dealing with sensitive data, outlines the approach taken and some of the outstanding issues to be tackled.
Encouraging and Facilitating Laboratory Scientists to Curate at Source
Authors: Willoughby Cerys , Frey Jeremy
Published: January 2018

Computers and computation have become essential to scientific activity and significant amounts of data are now captured digitally or even â€œborn digitalâ€. Consequently, there is more and more incentive to capture the full experiment records using digital tools, such as Electronic Laboratory Notebooks (ELNs), to enable the effective linking and publication of experiment design and methods with the digital data that is generated as a result. Inclusion of metadata for experiment records helps with providing access, effective curation, improving search, and providing context, and further enables effective sharing, collaboration, and reuse.
Regrettably, just providing researchers with the facility to add metadata to their experiment records does not mean that they will make use of it, or if they do, that the metadata they add will be relevant and useful. Our research has clearly indicated that researchers need support and tools to encourage them to create effective metadata. Tools, such as ELNs, provide an opportunity to encourage researchers to curate their records during their creation, but can also add extra value, by making use of the metadata that is generated to provide capabilities for research management and Open Science that extend far beyond what is possible with paper notebooks.
The Southampton Chemical Information group, has, for over fifteen years, investigated the use of the Web and other tools for the collection, curation, dissemination, reuse, and exploitation of scientific data and information. As part of this activity we have developed a number of ELNs, but a primary concern has been how best to ensure that the future development of such tools is both usable and useful to researchers and their communities, with a focus on curation at source. In this paper, we describe a number of user research and user studies to help answer questions about how our community makes use of tools and how we can better facilitate the capture and curation of experiment records and the related resources.
GÊNERO E RAÇA EM CENA: ANÁLISE COMPARATISTA DA REPRESENTAÇÃO DA MULHER INDÍGENA NA MINISSÉRIE A MURALHA E NA TELENOVELA UGA-UGA
Authors: Maciel Góes Aquésia
Published: January 2018

Este estudo analisa como a mulher indígena é representada em duas produções da Rede Globo, a partir de recortes de uma minissérie e uma telenovela, respectivamente: A muralha (2000) e Uga-Uga (2000-2001). Pretende-se demostrar como as mulheres indígenas são expostas nas narrativas televisivas, evidenciando as representações estereotipadas em papéis geralmente interpretados por atrizes não indígenas bronzeadas e/ou pintadas. Esta prática nos faz estabelecer uma relação com os blackfaces, que surgiram no século XIX, em que pintavam de preto os atores, para que estes interpretassem papéis de negros no teatro.

Na minissérie A muralha, a personagem que analisaremos será a índia Moatira, vivida pela atriz, não indígena, Maria Maya. Discutiremos a caracterização - prática que aqui chamaremos de redfaces. Na telenovela Uga-Uga (2000-2001), destacaremos a atuação da atriz indígena Silvia Nobre como Crococá. Analisaremos o papel designado a ela e como foi exposta ao contracenar com atores brancos. Discorreremos sobre as relações de poder e subalternização no que diz respeito a gênero, raça, classe social e os limites do cômico na TV brasileira.