bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of PFOA exposure on diminished ovarian reserve and its metabolism
Authors: Shen Haofei , Gao Min , Li Qiuyuan , Sun Huipeng , Jiang Yingdi , Liu Lihong , Wu Jingyuan , Yu Xiao , Jia Tianyu , Xin Yongan , Han Shiqiang , Wang Yiqing , Zhang Xuehong
Published: February 2023

Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction. This study aimed to examine the effect of PFOA concentration in follicular fluid during ovulation stimulation on embryo quality and the impact of PFOA exposure on the metabolic components of follicular fluid. This was a single-center prospective study that included 25 patients with diminished ovarian reserve (DOR), 25 with normal ovarian reserve (NOR), and 25 with polycystic ovary syndrome (PCOS). Follicular fluid samples were analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. We demonstrated that the PFOA levels of follicular fluid in the DOR group were higher than those in the NOR group and PCOS group (P < 0.05). PFOA concentration in the PCOS group was negatively correlated with high-quality embryos (P < 0.05). To gain more insight into the impact of PFOA on the metabolic composition of follicular fluid, we classified the DOR group based on the PFOA concentration, for which metabolomic analysis was performed. In the high-concentration PFOA group, there was an increase and a decrease in three and nine metabolites, respectively, compared to that in the low-concentration group. These results suggest that PFOA may alter the metabolic composition of follicular fluid, thus, affecting ovarian reserve function.
Therapeutic effects of TMF and catechol in pulmonary fibrosis: in vitro and in vivo analysis
Authors: Choi Jin-Hyuk , Kim Youngmee , Cho Moonjae
Published: February 2023

Idiopathic pulmonary fibrosis is a fatal lung disorder characterized by abnormal deposition of extracellular matrix (ECM), which is secreted by activated myofibroblasts. While the origin of myofibroblasts has been discussed, epithelial-mesenchymal transition (EMT) is being noticed as one of the mechanisms of myofibroblast activation. Recent studies have shown that reactive oxygen species appear to induce not only EMT but also fibrotic progression and maintenance. Therefore, we tested chemicals that have antioxidant capacity as drugs for fibrosis. To evaluate the effects of 4′,6,7-trimethoxyisoflavone (TMF) and catechol (CAT) on EMT and fibrosis, we used an in vitro transforming growth factor (TGF)-β1 or bleomycin-induced model and an in vivo BLM-induced model. The results showed that the co-administration of TMF/CAT ameliorated pulmonary fibrosis by decreasing EMT and ECM accumulation by hindering both Smad and non-Smad TGF-β signalling cascades. Furthermore, significant increases in the number of total immune cells (especially lymphocytes) were observed in BLM-treated animals treated with TMF/CAT. Our findings suggest that co-intervention with TMF/CAT may be a potential treatment for fibrosis.
Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens
Authors: Wu Tingyi , Wang Yuexin , Yu Jiazhi , Ren Xiaotong , Li Yuanting , Qiu Weiqiang , Li Xuemin
Published: February 2023

Background

The aim of the study was to compare the dynamic defocus curve on patients post-implantation of the extended depth-of-focus (EDOF) and monofocal intraocular lens (IOL).

Methods

A total of 62 age-related cataract patients receiving phacoemulsification with implantation of TECNIS Symfony (ZXR00) or monofocal IOLs were enrolled. The binocular static and dynamic defocus curves with corrected distance visual acuity were evaluated at one month postoperatively.

Results

The ZXR00 group achieved significantly better intermediate (P = 0.044) and near (P = 0.017) visual acuity (VA) than the monofocal group. Two groups had similar uncorrected and corrected distance VA (P > 0.05, respectively). The dynamic defocus curve revealed a smoother decline from 0.0 D to − 2.0 D in the ZXR00 group. Defocused dynamic VA in the ZXR00 group was significantly better (P < 0.05) except at 0.0 D (P = 0.724) and − 0.5 D (P = 0.176). The area under the curve (P = 0.002) and corrected dynamic vision accommodation (P = 0.001) derived from the dynamic defocus curves were better in the ZXR00 group. A positive correlation was observed between defocused dynamic and static VA in both groups (P < 0.001). Multiple linear regression analysis indicated that defocused static VA and corrected dynamic vision accommodation were significant influential factors for the defocused dynamic VA from − 1.0 D to − 3.0 D (P < 0.05).

Conclusions

The EDOF IOL provided similar distance vision, better intermediate and near vision, and a better overall dynamic defocus curve than the monofocal IOL. The dynamic defocus curve may be comprehensively applied to evaluate the all-distance dynamic visual performance post-cataract surgery.
Prescription factors influencing baloxavir prescription during the 2018/2019 and 2019/2020 seasons: a administrative database study in Japan
Authors: Fujiwara Naomi , Fujiwara Takashi , Ise Yuya
Published: February 2023

Background

We aimed to evaluate the factors associated with baloxavir prescription in Japanese hospitals using a health insurance claim-based database (MDV analyzer), during the 2018/2019 and 2019/2020 influenza seasons. The MDV analyzer contains anonymized claims data from approximately 420 Diagnosis Procedure Combination hospitals, and does not contain data from clinics.

Methods

Data were collected for influenza patients treated with anti-influenza drugs during the 2018/2019 and 2019/2020 influenza seasons. Multivariate analysis was used to identify factors associated with baloxavir prescription.

Results

During the study period, 322,063 influenza patients were included for analyses. In multivariate analysis, children, female sex, inpatient, hospital bed capacity, and private hospitals were negatively associated with baloxavir prescription. Compared to elderly patients, the adjusted odds ratio (OR) for baloxavir prescription was 0.612 (95% confidence interval (CI), 0.587–0.637) in children aged 6–11 years, and 0.119 (95% CI, 0.111–0.128) in children aged 0–5 years. Compared to small hospitals (bed capacity, 20–299), the adjusted OR for baloxavir prescription was 0.559 (95% CI, 0.540–0.578) in large hospitals (bed capacity, ≥ 500).

Conclusion

Children, female sex, inpatient, hospital bed capacity, and private hospitals were negatively associated with baloxavir prescription.
Incorporating random effects in biopharmaceutical control strategies
Authors: Oberleitner Thomas , Zahel Thomas , Kunzelmann Marco , Thoma Judith , Herwig Christoph
Published: February 2023

Objective

Random effects are often neglected when defining the control strategy for a biopharmaceutical process. In this article, we present a case study that highlights the importance of considering the variance introduced by random effects in the calculation of proven acceptable ranges (PAR), which form the basis of the control strategy.

Methods

Linear mixed models were used to model relations between process parameters and critical quality attributes in a set of unit operations that comprises a typical biopharmaceutical manufacturing process. Fitting such models yields estimates of fixed and random effect sizes as well as random and residual variance components. To form PARs, tolerance intervals specific to mixed models were applied that incorporate the random effect contribution to variance.

Results

We compared standardized fixed and random effect sizes for each unit operation and CQA. The results show that the investigated random effect is not only significant but in some unit operations even larger than the average fixed effect. A comparison between ordinary least squares and mixed models tolerance intervals shows that neglecting the contribution of the random effect can result in PARs that are too optimistic.

Conclusions

Uncontrollable effects such as week-to-week variability play a major role in process variability and can be modelled as a random effect. Following a workflow such as the one suggested in this article, random effects can be incorporated into a statistically sound control strategy, leading to lowered out of specification results and reduced patient risk.
Multiple expressions of “expert” abnormality gist in novices following perceptual learning
Authors: DiGirolamo Gregory J. , DiDominica Megan , Qadri Muhammad A. J. , Kellman Philip J. , Krasne Sally , Massey Christine , Rosen Max P.
Published: February 2023

With a brief half-second presentation, a medical expert can determine at above chance levels whether a medical scan she sees is abnormal based on a first impression arising from an initial global image process, termed “gist.” The nature of gist processing is debated but this debate stems from results in medical experts who have years of perceptual experience. The aim of the present study was to determine if gist processing for medical images occurs in naïve (non-medically trained) participants who received a brief perceptual training and to tease apart the nature of that gist signal. We trained 20 naïve participants on a brief perceptual-adaptive training of histology images. After training, naïve observers were able to obtain abnormality detection and abnormality categorization above chance, from a brief 500 ms masked presentation of a histology image, hence showing “gist.” The global signal demonstrated in perceptually trained naïve participants demonstrated multiple dissociable components, with some of these components relating to how rapidly naïve participants learned a normal template during perceptual learning. We suggest that multiple gist signals are present when experts view medical images derived from the tens of thousands of images that they are exposed to throughout their training and careers. We also suggest that a directed learning of a normal template may produce better abnormality detection and identification in radiologists and pathologists.
Comparison of integrin αvβ3 expression with 68Ga-NODAGA-RGD PET/CT and glucose metabolism with 18F-FDG PET/CT in esophageal or gastroesophageal junction cancers
Authors: Dietz Matthieu , Dunet Vincent , Mantziari Styliani , Pomoni Anastasia , Dias Correia Ricardo , Testart Dardel Nathalie , Boughdad Sarah , Nicod Lalonde Marie , Treglia Giorgio , Schafer Markus , Schaefer Niklaus , Prior John O.
Published: February 2023

Background

The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68Ga-NODAGA-RGD PET/CT with that of 18F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination.

Methods

Ten 68Ga-NODAGA-RGD and ten 18F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40–69 y). Maximum SUV (SUVmax) and metabolic tumor volumes (MTV) were calculated. The Mann–Whitney U test and Spearman correlation analysis (ρ) were used.

Results

68Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. 18F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUVmax of 18F-FDG was significantly higher than those of 68Ga-NODAGA-RGD (4.9 [3.7–11.3] vs. 3.2 [2.6–4.2] g/mL, p = 0.014). Only one participant showed a higher SUVmax in an osseous metastasis with 68Ga-NODAGA-RGD as compared to 18F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between 18F-FDG and 68Ga-NODAGA-RGD PET parameters (ρ = 0.56, p = 0.012 for SUVmax, ρ = 0.78, p < 0.001 for lesion-to-background ratios and ρ = 0.58, p = 0.024 for MTV). We observed that 18F-FDG uptake was homogenous inside all the confirmed primary sites (n = 9). In contrast, 68Ga-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%).

Conclusions

In conclusion, 68Ga-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to 18F-FDG. However, the results suggest that PET imaging of integrin αvβ3 expression may provide complementary information and could aid in tumor diversity and delineation.

Trial registration: Trial registration: NCT02666547. Registered January 28, 2016—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02666547.
Coping strategies to overcome psychological distress and fear during COVID-19 pandemic in Kuwait
Authors: Elaidy Asmaa M. , Hammoud Majeda S. , N. Albatineh Ahmed , Ridha Fatma Mustafa , Hammoud Sabri M. , Elsadek Hala M. , Rahman Muhammad Aziz
Published: February 2023

Background

The COVID-19 pandemic has detrimental effects on both physical and psychological well-being of community people worldwide. The purpose of this research was to determine coping strategies and the factors associated with psychological distress and fear among adults in Kuwait during the COVID-19 pandemic.

Results

Participants with good-excellent mental health perception had significantly lower prevalence of reporting high psychological distress, while those identified as patients as used health services in the past 4 weeks had significantly higher prevalence of reporting high psychological distress. On the other hand, individuals born in the same country of residence, whose financial situation was impacted by COVID-19 had significantly lower prevalence of reporting high levels of fear from COVID-19. Those with an income source, with co-morbidities, tested negative to COVID-19, being frontline or essential worker, reported medium to high psychological distress and had significantly higher prevalence of high levels of fear of COVID-19.

Conclusions

Mental health services should be provided in addition to the existing services in primary healthcare settings, so that the impact of ongoing pandemic on psychological wellbeing of people in Kuwait can be addressed.
Development and validation of stability indicating UPLC method for the simultaneous estimation of triamterene and hydrochlorothiazide in combined dosage forms using quality by design approach
Authors: Devi D. Akila , Bhavani P. Geetha
Published: February 2023

Background

According to the information gathered from the literature, no technique for UPLC of triamterene and hydrochlorothiazide employing QbD in the formulations has been published. The technique development by incorporating QbD and validating for accuracy, linearity, precision, LOQ, LOD, ruggedness and selectivity as per ICH is part of the work’s modernity.

Results

Screening investigations led to the selection of cmps. Peak tailing was evaluated as a metric of technique robustness based on these important analytical attributes, namely retention time. With a 0.1 percent OPN: methanol (40:60) mobile phase, a flow rate of 0.3 ml/min, a wave length of 224 nm, an injection volume of 41, and a run time of 6 min, the best chromatographic separation was attained.

Conclusions

The method was verified using ICH criteria, which ensure a high level of linearity, accuracy, precision, specificity and robustness. As a result, the suggested approach is regarded as a quick and accurate method for estimating triamterene and hydrochlorothiazide at the same time.
Open and percutaneous pediatric tracheostomy: comorbidities and in-hospital mortality
Authors: Schemm Jeffrey , Danis David O’Neil , Howard Daniel , Rodriguez Erika , Dong Kaylin , Fazelpour Sherwin , Levi Jessica R.
Published: February 2023

Background

Tracheostomy procedures are used to establish a surgical airway in patients when non-invasive methods fail to offer adequate support. In pediatric patients, this procedure is relatively rare, and data on patients is scarce, limiting the ability of physicians to contextualize patient outcomes and identify those most at risk. This can be crucial, as research has shown that early tracheostomy in pediatric patients may improve clinical outcomes. The objective of this study is to characterize the comorbidities of pediatric patients undergoing open and percutaneous tracheostomies and examine their association with in-hospital mortality, as well as to compare patient demographics and comorbidity frequency between the two approaches. The 2016 Kids’ Inpatient Database was used to identify patients younger than 21 with ICD-CM-10 codes for open or percutaneous tracheostomies to determine demographic characteristics and identify the most frequent comorbidities in these patient cohorts.

Results

A weighted total of 5229 cases were analyzed. Congenital cardiopulmonary defects, newborn respiratory diseases, and traumatic lung or brain injury were the most common comorbidities for tracheostomy patients. In open tracheostomies, there was an increased likelihood of in-hospital mortality in patients aged less than one (OR = 2.2; 95% CI, 1.6–3.0) and in patients with atrial septal defects (OR = 1.9; 95% CI, 1.5–2.5), patent ductus arteriosus (OR = 2.5, 95% CI, 2.0–3.3), bronchopulmonary dysplasia (OR = 2.1; 95% CI, 1.6–2.8), and acute kidney injury (OR = 5.6, 95% CI, 4.3–7.2). Trauma-related comorbidities were more common in patients who underwent percutaneous procedures and were not associated with an increased likelihood of mortality. Patient age < 1 was associated with an increased risk of in-hospital mortality in both the open (OR = 2.2; 95% CI, 1.6–3.0) and percutaneous (OR = 2.3, 95% CI (1.3–3.9) approaches.

Conclusion

There are many indications for pediatric tracheostomy, and patients often present with complicated disease profiles and complicated courses of care. Broadly, we found that congenital cardiopulmonary defects were associated with a higher likelihood of in-hospital patient mortality, especially in younger patients undergoing an open-approach procedure. Patients undergoing a percutaneous-approach procedure were more likely to have trauma-related comorbidities such as pneumothorax or brain hemorrhage that were not associated with in-hospital mortality.
Culture-negative necrotizing otitis externa: diagnosis and management
Authors: Chaabouni Mohamed Amine , Achour Imen , Yousfi Ghada , Thabet Wadii , Trigui Majdi , Kallel Souha , Charfeddine Ilhem
Published: February 2023

Objective

We aim to describe the clinical features and therapeutic management of necrotizing otitis externa (NOE) with negative culture.

Patients and methods

We included all patients with NOE, who were treated in the period between 2008 and 2020 in our department.

Results

A total of 25 cases of NOE were included. The result of the culture was negative in 13 cases (52%). All patients received a local treatment prior to hospitalization, and eight patients (61.5%) received oral antibiotic. A sampling of the otorrhea was done for all patients. Fungal serology was performed for six patients; it was positive in two cases. The prescribed first-line was ciprofloxacin in combination with ceftazidime for 10 patients, while it was based on the use of imipenem with ciprofloxacin for 2 patients and one patient only received ciprofloxacin. An improvement was noted in 10 cases (77%). The second-line treatment in the three cases of resistance was imipenem with ciprofloxacin in one case. For the two patients with a positive aspergillus serology, one patient received teicoplanin, fusidic acid, imipenem, and voriconazole and the other patient received voriconazole. The total duration of the treatment was a minimum of 6 weeks. An improvement was noted in all cases, and recurrence was noted in 3 cases.

Conclusion

In our study, there were no clinical or radiological specificities noted in NEO with negative culture. Sampling must be repeated. Fungal origin should be suspected in refractory forms and empiric antifungal treatment may be useful.
Memorial
Authors: Stockwell John W. , Vasconcelos Ivan
Published: February 2023

The geophysical community has lost one of its brightest lights with the passing of Norman Bleistein, university emeritus professor at the Colorado School of Mines (CSM).
Memorial
Authors: O'Connor Lou , Witherly Ken
Published: February 2023

Mining geophysicist Richard “Dutch” Van Blaricom passed away in December 2020 in Spokane, Washington, after a brief illness.
Psychometric properties of the Greek versions of the Pandemic-Related Pregnancy Stress Scale and the Pandemic-Related Postpartum Stress Scale and associated risk factors during the second year of the COVID-19 pandemic
Authors: Siafaka Vassiliki , Tsonis Orestis , Christogiannis Christos , Kontouli Katerina-Maria , Margariti Kalypso , Barbalia Zoe , Flindris Stefanos , Manifava Eleni , Paschopoulou Kasmiria Ioanna , Tzioras Spyros , Baltogianni Maria , Mavridis Dimitris , Paschopoulos Minas
Published: February 2023

Background

The COVID-19 pandemic has affected perinatal mental health. Reliable tools are needed to assess perinatal stress during pandemic situations.

Aims

To assess the psychometric properties of the Greek versions of the Pandemic-Related Pregnancy Stress Scale (PREPS) and the Pandemic-Related Postpartum Stress Scale (PREPS-PP) and to explore the associations between women's characteristics and perinatal stress during the second pandemic wave.

Methods

The PREPS and PREPS-PP were completed by 264 pregnant and 188 postpartum women, respectively, who also completed the State-Trait Anxiety Inventory (STAI) and the Edinburgh Perinatal Depression Scale (EPDS).

Results

The internal consistency was similar for PREPS and PREPS-PP. It was good for preparedness stress (a = 0.77 and α = 0.71, respectively) and infection stress (α = 0.83 for both scales) but low for positive appraisal (α = 0.46 and α = 0.41, respectively). Of the pregnant women, 55.33% and 55.27%, respectively, reported scores of ≥40 on STAI-S and STAI-T, and the respective percentages for the postpartum women were 47.34% and 46.80%. In addition, 14.39% of the pregnant women and 20.74% of the postpartum women scored ≥13 on the EPDS. Higher preparedness stress on PREPS and PREPS-PP was associated with primiparity (P = 0.022 and P = 0.021, respectively) and disrupted perinatal care (P = 0.069 and P = 0.007, respectively). In postpartum women, higher infection stress was associated with chronic disease (P = 0.037), primiparity (P = 0.02) and perceived risk of infection (P = 0.065). Higher score on infection stress was associated with disrupted perinatal care in both groups (P = 0.107 and P = 0.010, respectively).

Conclusions

The Greek versions of PREPS and PREPS-PP are valid tools for the assessment of women at risk of perinatal stress during a health crisis.
Consistency Between State's Cancer Registry and All-Payer Claims Database in Documented Radiation Therapy Among Patients Who Received Breast Conservative Surgery
Authors: Li Chenghui , Malapati Sindhu J. , Guire John T. , Hutchins Laura F.
Published: February 2023

PURPOSE

Arkansas is one of only four known states that have linked All-Payer Claims Database (APCD) to state's cancer registry (Arkansas Cancer Registry [ACR]). We evaluated the reporting consistency of radiation therapy (RT) between the two sources.

METHODS

Women age ≥ 18 years diagnosed in 2013-2017 with early-stage hormone receptor–positive breast cancer who received breast-conserving surgery were identified. Patients must have continuous insurance coverage (any private plans, Medicaid, and Medicare) in the 13 months (month of diagnosis and 12 months after). Receipt of RT was identified independently from ACR and APCD. We calculated sensitivity, specificity, positive predictive value, and negative predictive value for receipt of RT coded by the registry compared with APCD billing claims as the gold standard. We assessed the degree of concordance between the data sources by Cohen's kappa statistics.

RESULTS

The final sample included 2,695 patients who were in both databases and satisfied our inclusion/exclusion criteria. Using APCD as the gold standard, there were high sensitivity (88.1%) and positive predictive value (87.7%) and moderate specificity (71.1%) and negative predictive value (71.8%). The overall agreement between the two sources was 83.0%, with a kappa statistic of 0.59 (95% CI, 0.56 to 0.63). Consistency measures varied by age, stage, and insurance type with Medicare fee-for-service coverage only having the best and private insurance only the worse consistency.

CONCLUSION

In patients with early-stage hormone receptor–positive breast cancer who received breast-conserving surgery, recording of RT receipt was moderately consistent between Arkansas APCD and ACR. Future studies are needed to identify factors affecting reporting consistency to better use this unique resource in addressing population health problems.
Genomic Complexity as a Biomarker to De-Escalate Adjuvant Imatinib Treatment in High-Risk Gastrointestinal Stromal Tumor
Authors: Boye Kjetil , Gorunova Ludmila , Gunawan Bastian , Hompland Ivar , Sander Bjoern , Panagopoulos Ioannis , Langer Claus , Golas Monika , Heim Sverre , Füzesi László , Hølmebakk Toto , Micci Francesca
Published: February 2023

PURPOSE

Adjuvant imatinib treatment is recommended for patients with localized gastrointestinal stromal tumor (GIST) at high risk of recurrence. Almost half of high-risk patients are cured by surgery alone, indicating a need for improved selection of patients for adjuvant therapy. The aim of this study was to investigate if genomic tumor complexity could be used as a prognostic biomarker.

METHODS

The discovery cohort consisted of patients who underwent resection of primary GIST at Oslo University Hospital between 1998 and 2020. Karyotypes were categorized as simple if they had ≤ 5 chromosomal changes and complex if there were > 5 chromosomal aberrations. Validation was performed in an independent patient cohort where chromosomal imbalances were mapped using comparative genomic hybridization.

RESULTS

Chromosomal aberrations were detected in 206 tumors, of which 76 had a complex karyotype. The most frequently observed changes were losses at 14q, 22q, 1p, and 15q. The 5-year recurrence-free survival (RFS) in patients classified as very low, low, or intermediate risk was 99%. High-risk patients with a simple tumor karyotype had an estimated 5-year RFS of 94%, and patients with a complex karyotype had an estimated 5-year RFS of 51%. A complex karyotype was associated with poor RFS in patients with and without adjuvant imatinib treatment and in multivariable analysis adjusted for tumor site, size, mitotic count, and rupture. The prognostic impact of genomic complexity was confirmed in the validation cohort. In both cohorts, the 5-year disease-specific survival was > 90% for high-risk patients with genomically simple tumors.

CONCLUSION

Genomic tumor complexity is an independent prognostic biomarker in localized, high-risk GIST. Recurrences were infrequent for tumors with simple karyotypes. De-escalation of adjuvant imatinib treatment should be explored in patients with cytogenetically simple GISTs.
Dearth of ICD Codes for Complications of Immune Checkpoint Inhibitors Impedes Clinical Care and Research
Authors: Cheung Yee-Ming M , Hamnvik Ole-Petter R , Shariff Afreen , Gallagher Emily J
Published: February 2023

Immune checkpoint inhibitors (ICIs) are a rapidly expanding class of targeted therapies effective in the treatment of various cancers. However, while efficacious, ICIs have been associated with treatment complications, namely immune-related adverse events (irAEs). IrAEs of the endocrine system are among the most commonly reported irAEs, but despite their high incidence, standardized disease definitions and endocrine IrAE-specific International Classification of Diseases (ICD) codes remain lacking. This dearth of standardized nomenclature and ICD codes has in many ways impeded both the clinical care of patients and the progress of endocrine irAE-related research. ICD codes are used internationally and are essential for medical claims reporting in the health care setting, and they provide a universal language system for recording, reporting, and monitoring diseases. These codes are also a well-accepted form of electronic health record data capture that facilitates the collection, storage, and sharing of data. Therefore, the lack of standardized disease definitions and ICD codes has been associated with misclassification and suboptimal management of individuals with endocrine irAEs and has also been associated with reduced data availability, comparability, and quality. Harmonized and clinically relevant disease definitions along with the subsequent development of endocrine-irAE-specific ICD codes will provide a systematic approach to understanding the spectrum and burden of endocrine irAE diseases, and will have a positive effect across clinical, public health, and research settings.
Αναπαριστώντας την αποχώρηση των Ελλήνων από την Αίγυπτο
Authors: Ελαμπόντι Σαμέχ
Published: February 2023

Η παρούσα διατριβή αφιερώνεται στη μελέτη του φαινομένου της αποχώρησης των Αιγυπτιωτών Ελλήνων από την Αίγυπτο μετά το 1949 μέχρι το 1967, χρησιμοποιώντας προς τούτο ως πρωτογενές υλικό τον αιγυπτιακό και αιγυπτιώτικο Τύπο της εποχής. Δευτερευόντως, αξιοποιούνται κι άλλες πρωτογενείς πηγές, όπως είναι το αρχειακό υλικό των αιγυπτιακών υπουργείων Εσωτερικών, Οικονομικών και Παιδείας, καθώς και τα πρακτικά των συνεδριάσεων της αιγυπτιακής βουλής, σε σύγκριση με το αρχειακό υλικό του ΥΠ.ΕΞ της Ελλάδας, των ελληνικών Κοινοτήτων Αλεξάνδρειας και Καΐρου. Αυτή η συγκριτική ανάλυση μάς έδωσε τη δυνατότητα να αποκτήσουμε μια σφαιρικότερη άποψη και νέες αναπαραστάσεις, χρησιμοποιώντας ένα επιπλέον πρωτογενές υλικό, τοποθετώντας και τα δύο αρχεία στην δέουσα ιστορική τους θέση.
Ο θεσμός της οικογένειας στο δίκαιο των Ιερών Κανόνων
Authors: Μουτάφης Σταύρος
Published: February 2023

Πώς το Κανονικό Δίκαιο της Εκκλησίας προστάτευσε το θεσμό της οικογένειας;Από πότε η οικογένεια τίθεται στο επίκεντρο της Εκκλησίας ;Ποιοι ιδιαίτεροι ιστορικοί λόγοι οδήγησαν σ΄ αυτό;Το διαζύγιο ήταν και είναι μια εύκολη υπόθεση για την Εκκλησία;Ποια ήταν η θέση της γυναίκας μέσα στην οικογένεια πριν από την έλευση του Ιησού Χριστού;Πώς αντιμετωπίζονται οι σύγχρονες μορφές συμβίωσης από την Εκκλησία;Ποιο είναι το σύνολο των αναφορών για την οικογένεια στο σώμα των Ιερών Κανόνων;Αυτά και άλλα πολλά απαντώνται στην παρούσα διατριβή πάντοτε υπό το πρίσμα Θεολογίας της Εκκλησίας.
Το νομικό καθεστώς της εποπτείας των τηλεπικοινωνιών στην εθνική, την ευρωπαϊκή και τη διεθνή έννομη τάξη
Authors: Τζιουρά Φανή
Published: February 2023

Αντικείμενο έρευνας της διατριβής αυτής αποτελεί το νομικό καθεστώς της εποπτείας των τηλεπικοινωνιών στην εθνική, την Ευρωπαϊκή και τη διεθνή έννομη τάξη. Στο πλαίσιο αυτό ερευνάται η διαδικασία της απελευθέρωσης των προϊόντων τεχνολογίας και υπηρεσιών του τομέα των τηλεπικοινωνιών, υπό το σύστημα GATT/ΠΟΕ, παράλληλα με τη διαδικασία της εναρμόνισης των κανόνων για τη ρύθμιση της αγοράς των τηλεπικοινωνιών, στο επίπεδο του Κοινοτικού δικαίου. Αναπτύσσεται το σύνολο των ανεξάρτητων αρχών που διαθέτουν ρυθμιστικές αρμοδιότητες στον τομέα των τηλεπικοινωνιών στην εθνική έννομη τάξη και συγκεκριμένα οι αρμοδιότητες της Εθνικής Επιτροπής Τηλεπικοινωνιών και Ταχυδρομείων (ΕΕΤΤ), της Αρχής Προστασίας Δεδομένων Προσωπικού Χαρακτήρα (ΑΠΔΠΧ) και της Αρχής Διασφάλισης του Απορρήτου των Επικοινωνιών (ΑΔΑΕ), μαζί με τον καίριας σημασίας ρόλο του Συνηγόρου του Καταναλωτή. Εξετάζονται ακόμη σε ενωσιακό επίπεδο, τα αναθεωρημένα, πλέον, καθήκοντα του του Φορέα Ευρωπαϊκών Ρυθμιστικών Αρχών για τις Ηλεκτρονικές Επικοινωνίες (Body of European Regulators for Electronic Communications - BEREC) σε σχέση με την δημιουργία μιας εσωτερικής αγοράς για τις ηλεκτρονικές επικοινωνίες, ενώ παρουσιάζεται και το κανονιστικό πλαίσιο για τον έλεγχο των άμεσων ξένων επενδύσεων στην Ευρωπαϊκή Ένωση αναφορικά με τις εταιρίες Τεχνολογιών Πληροφορικής και Επικοινωνίας καθώς και οι νέοι Κανονισμοί της ΕΕ σχετικά με τις Ψηφιακές Αγορές, τις Ψηφιακές Υπηρεσίες και την Τεχνητή Νοημοσύνη. Οι στόχοι της έρευνας αναπτύσσονται στην παρουσίαση, για πρώτη φορά στην ελληνική βιβλιογραφία, του νομικού καθεστώτος της εποπτείας των τηλεπικοινωνιών, σε τρεις διαφορετικές, πλην όμως, αλληλένδετες, έννομες τάξεις, στην ανάδειξη των αδυναμιών του συστήματος της εποπτείας και στην εξέταση των προκλήσεων που επιφέρει η πρόοδος των ΤΠΕ στα ατομικά δικαιώματα, στο βαθμό που οι ηλεκτρονικές επικοινωνίες διεισδύουν σε κάθε τομέα της ιδιωτικής και δημόσιας σφαίρας.
Το ορθόδοξο μοναστικό ήθος και η σύγχρονη Βιώσιμη ανάπτυξη
Authors: Μαρκαντώνης Ευάγγελος
Published: February 2023

Στην παρούσα Διατριβή παρουσιάζεται αναλυτικά το Ορθόδοξο μοναστικό ήθος, ο τρόπος διαμόρφωσής του και τα επιμέρους χαρακτηριστικά του, τα οποία οδηγούν τους μοναχούς/τις μοναχές σε μια πορεία εσωτερικής μεταμόρφωσης-αλλαγής στάσης, ιδιαίτερα φιλοπεριβαλλοντικής. Στη συνέχεια γίνεται αναφορά στην έννοια της Βιώσιμης Ανάπτυξης, στους σταθμούς διαμόρφωσης και εξέλιξής της και στις Αρχές που τη διέπουν, ενώ παρουσιάζεται ο σύγχρονος προσανατολισμός της με τους 17 Στόχους για τη Βιώσιμη Ανάπτυξη ως το 2030. Κατόπιν διερευνάται και δίνεται απάντηση σε 4 ερευνητικά ερωτήματα. Κατ’ αρχάς διαπιστώνεται ότι υπάρχουν πολλά κοινά στοιχεία μεταξύ του Ορθόδοξου μοναστικού ήθους και των Αρχών της Βιώσιμης Ανάπτυξης. Στη συνέχεια καταδεικνύεται ότι το Ορθόδοξο μοναστικό ήθος αφ’ ενός συμβάλλει στην επίτευξη 13 από τους 17 Στόχους της Βιώσιμης Ανάπτυξης ως το 2030, αφ’ ετέρου όμως και κυρίως συμβάλλει στον εσωτερικό μετασχηματισμό, που σημαίνει αλλαγή στάσης ζωής, δηλαδή έμπρακτης αγάπης προς τον συνάνθρωπο και ολόκληρη τη Δημιουργία. Οι διαπιστώσεις αυτές επιβεβαιώθηκαν με τη διεξαγωγή εμπειρικής έρευνας μεικτού (ποσοτικού και ποιοτικού) χαρακτήρα σε 37 μοναστήρια της Κρήτης. Μέσω ερωτηματολογίου, συνεντεύξεων και επιτόπιων καταγραφών, μελετήθηκε ποιους Στόχους της Βιώσιμης Ανάπτυξηςικανοποιούν οι Μονές της Κρήτης και σε ποιον βαθμό. Τέλος, παρουσιάζονται περιπτώσεις μοναχών/μοναζουσών που επιβεβαιώνουν στην καθημερινότητά τους αυτόν τον εσωτερικό μετασχηματισμό.
Maré cohort-profile: a prospective cohort study based in a socially vulnerable community during the COVID-19 pandemic in Rio de Janeiro, Brazil
Authors: A Batista-da-Silva Amanda , T Ranzani Olivia , M de Paulo Daniela , L Braunstein Mariana , R Bozza Helena , Fischer Ronald , V Ramos Grazielle , M C Dias Carolina , P da Silva Everton , E Arouca Luna , L S Bastos Leonardo , T Ranzani Otavio , Hamacher Silvio , A Bozza Fernando
Published: February 2023

Background: Socially vulnerable populations were vastly affected by the COVID-19 pandemic. The pandemic significantly impacted Brazil, pressuring its healthcare system for several months, with high mortality rates, even among the youngest population. Cohort studies combining disease surveillance are essential for understanding virus circulation in the community, surrogates of protection, vaccine effectiveness, and demand for health resources.

Methods: Here, we present the protocol for a community-based prospective cohort study in the largest complex of favelas (slums) in Rio de Janeiro, Brazil (Complexo da Maré). The study participants are residents initially recruited during a massive vaccination campaign in the community. Five waves of data collection at approximately six-month intervals were planned. The first two waves have been completed at the time of writing this study protocol, and the third is underway. The protocol comprises interviews, blood sampling, and records linkage with secondary data to enrich the profiles of cohort participants and community information. We will describe COVID-19 seroprevalence, socio-demographic characteristics, and the burden of COVID-19, followed by estimating the association of socioeconomic factors and the burden of disease with seroprevalence.

Discussion: The primary aims of the study are to assess COVID-19 clinical, epidemiological and genomic profiles and outcomes in residents from Maré, including vaccine effectiveness, surrogates of immune protection, virus transmission in households, and the overall burden of the pandemic.
Metastatic bone damage in prostate cancer as a cause of chronic musculoskeletal pain
Authors: Blashkevich O.
Published: February 2023

A clinical case of detection of prostate cancer with multiple bone metastases is presented. It has been clearly demonstrated that oncopathology in the early stages may go unnoticed due to the absence of specific symptoms, as well as the ability to mimic other nosologies in clinical manifestations during its progression. The importance of oncological alertness on the part of the doctor is shown, the need for medical examination is once again emphasized.
Variants of the course of ankylosing spondylitis on the example of a clinical case of twin brothers
Authors: Dvornikova O.
Published: February 2023

The case of ankylosing spondylitis in twin brothers is considered. The influence of various factors on the trigger mechanism of the disease is analyzed. Both twin brothers have a genetic predisposition to the disease, but only one of them has provoking agents, in the form of injury and inflammation.
Therianthropes in a Cartesian and an Animistic Cosmology: Beyond-the-Pale Monsters versus Being-in-the World Others
Authors: Guenther Mathias
Published: February 2023

The nature of human-animal hybrid beings (or therianthropes) is examined in an Animistic (traditional San Bushman) and a Cartesian (Early Modern Western) cosmology. In each ontological ambiguity is imagined and conceptualized in different terms. One of them is through monstrosity, which, in the Western schema, is equated with human-animal hybridity. This equivalence threatens the boundaries and categories that buttress western cosmology, through a being – the human-animal hybrid – deemed a conceptual and epistemological abomination. It elicits a category crisis that is as much cerebral as it is visceral as the were-beings it conceives are feared and demonized. No such valences attach to therianthropes in the cosmology described in this paper. It is an “entangled” cosmology shot through with ambiguity and fluidity in which human-animal hybridity is neither abominable nor feared. Instead, as a pervasive and salient theme of San world view and lifeways, especially its expressive and ritual spheres, along with hunting, ontological mutability becomes an integral component of people’s thoughts and lives and thereby normalized and naturalized. Beings partaking of this state are deemed another species of being with whom humans engage as other-than-humans, on shared social terms. Monsters are beings who negate or transgress the moral foundation of the social order. San monstrosity, conceptually and phenomenologically, becomes thereby a matter of deviation from social (moral) pre/proscriptions rather than from classificatory (ontological) ones. This basic conceptual difference notwithstanding, we also find a fundamental commonality: the inversion, through monsters and monstrosity, of each cosmology’s underlying epistemic matrices, of structure and ambiguity, respectively.
Michaiła Bułhakowa droga do filmu
Authors: Przebinda Igor
Published: February 2023

W niniejszym artykule podjęta została próba naszkicowania obrazu twórczości literackiej (prozatorskiej i dramaturgicznej) Michaiła Bułhakowa, wraz z jej tłem historyczno-politycznym, jako wstępu do jego własnej przygody z filmem oraz późniejszych, już pośmiertnych, ekranizacji jego dzieł – na czele z Mistrzem i Małgorzatą. Przy takim ujęciu przejście Bułhakowa od prozy (Biała Gwardia) do dramaturgii (Dni Turbinów) może się jawić jako dopiero pierwszy krok ku jego przygodzie z filmem. Wydaje się bowiem, że droga od powieści przez dramat do filmu jest znacznie łatwiejsza niż bezpośrednia droga od powieści do filmu. Zarysowane zostały tu zatem zarówno konteksty teatralne Bułhakowa, jak i konteksty muzyczne, z uwzględnieniem przedstawień operowych i musicalowych. Opisano także zwięźle autorskie scenariusze Bułhakowa do niezrealizowanych ostatecznie ekranizacji Rewizora i Martwych dusz Gogola. Została podkreślona rola przestrzeni Kijowa i Moskwy, jako dwóch z kilku najistotniejszych, obok Jerozolimy, Rzymu i Paryża, mitycznych miast pisarza. W artykule uwypuklona została kinematograficzna natura dzieł Bułhakowa. Przywołane zostają w tym filmowo-teatralnym kontekście opinie badawcze takich autorów jak – Konstanty Paustowski, Andrzej Drawicz, Marietta Czudakowa, Aleksy Warłamow, Eugeniusz Zamiatin, Miron Pietrowski, Alicja Helman, Joanna Wojnicka. Zarysowany wstępnie zostaje również urbanistyczny wymiar powieści Mistrz i Małgorzata, jako apoteozy miasta i osiągnięć cywilizacji, co także przełoży się na późniejsze ekranizacje tego arcydzieła.
O książkach rysunkowych Stanisława Wyspiańskiego
Authors: Łopatkiewicz Tadeusz
Published: February 2023

Młodzieńcze szkicowniki Stanisława Wyspiańskiego z lat 1876–1891 stanowią cenne źródło w badaniach nad edukacją artystyczną i wczesną twórczością artysty. Czternaście tek rysunków oraz notatek, zachowanych do dziś, dokumentuje rozwój talentu Wyspiańskiego – od dziecięcych szkiców, poprzez kopiowanie wartościowych dzieł sztuki polskiej i obcej, studia nad twórczością Dürera i Schongauera, terenowe prace inwentaryzacyjne zabytków na Ukrainie, w okolicach Opoczna i w Małopolsce, aż po naukowo-artystyczne efekty jego podróży po Europie Południowej i Zachodniej. Podręczny i pomocniczy charakter szkicowników Wyspiańskiego spowodował, iż wiele z nich nie dotrwało do dziś, inne zaś są niekompletne i w ogólnie złym stanie. Stosunkowo najlepiej zachowały się dwa zespoły tek rysunkowych – zabezpieczone przez Janinę Stankiewiczową, ciotkę artysty, oraz te, które zakupił Stanisław Tomkowicz, galicyjski konserwator zabytków. Ze skomplikowanych losów tych archiwaliów wynika wprost ich dzisiejsze rozproszenie w zbiorach wielu muzeów i kolekcjach prywatnych: Muzeum Narodowego w Krakowie, Muzeum Uniwersytetu Jagiellońskiego, Muzeum Narodowego w Warszawie. Artykuł jest przeglądem szkicowników Wyspiańskiego zachowanych w zbiorach publicznych, przybliża kulisy powstania poszczególnych tek rysunkowych oraz sytuuje je na tle działalności artysty.
Ścigany listem gończym Dmitrij Głuchowski
Authors: Gołąbek Bartosz
Published: February 2023

Dmitrij Głuchowski to najpopularniejszy rosyjski pisarz współczesności. Szerokiemu gremium czytelników dał się poznać jako zdolny autor tekstów postapokaliptycznych. Na kanwie jego pierwszej powieści w tym gatunku, Metro 2033 z 2005 roku, obok autorskiej kontynuacji powstała cała rodzina tekstów o podobnym profilu pod marką Uniwersum Metro, gra komputerowa, scenariusz filmowy. Głuchowski to bardzo aktywny pisarz, ale także scenarzysta filmowy, którego dzieła, oparte na własnej twórczości literackiej, przynoszą mu spore zainteresowanie pasjonatów kina. Jego zawodowa kariera prowadziła do pisarstwa poprzez świat mediów. Głuchowski ma za sobą epizody pracy w ważnych kanałach informacyjnych, w tym rosyjskim propagandowym Russia Today (RT). Te kompetencje umożliwiły mu świadome i sprawne korzystanie z medialnego wpływu już poza branżą. Po ataku Rosji na Ukrainę, w lutym 2022 roku, pisarz potwierdził znaną już wcześniejszej z jego publicystyki radykalnie antyputinowską i antywojenną postawę, starając się jednocześnie w swoich wystąpieniach chronić rosyjską kulturę przed pustymi atakami oraz eksponować zbrodniczy wpływ społeczny telewizyjnej propagandy w putinowskiej Rosji. Za swoją nieugiętą postawę i ostrą krytykę Kremla, w czerwcu 2022 roku trafił na listę poszukiwanych przez rosyjską prokuraturę z zarzutami o dyskredytację władzy. słowa
Mozolne początki zmagań o ochronę zabytków w Galicji. Rozważania na marginesie najnowszej książki Tadeusza Łopatkiewicza
Authors: Laskowski Andrzej
Published: February 2023

Artykuł zawiera rozważania na temat procesu rodzenia się i powolnego dojrzewania systemu ochrony zabytków w Galicji, jednym z krajów koronnych monarchii habsburskiej, zachodzącego w latach 60. i 70. XIX wieku. Jedną z kluczowym postaci tego czasu był Ludwik Mieczysław Lubicz Potocki, konserwator zabytków działający na terenie Galicji Wschodniej, obejmujący swoim działaniem 49 ówczesnych powiatów politycznych, w tym m.in. miasto Krosno i jego okolice. Punktem wyjścia do rozważań jest najnowsza (wydana w 2022 roku) książka autorstwa Tadeusza Łopatkiewicza poświęcona postaci tego konserwatora i jego działalności na terenie Krosna i okolic.

Wspomniana książka przybliża postać samego konserwatora i koleje jego życia (ostatni rozdział), pokazuje tło, na jakim przyszło mu wzrastać, zdobywać wykształcenie i podejmować współpracę w zakresie odkrywania i interpretacji śladów przeszłości (rozdział pierwszy), prezentuje zręby rodzącego się systemu ochrony zabytków w monarchii habsburskiej, w tym w Galicji (rozdział drugi) oraz – co najważniejsze – w oparciu o odnalezione źródła przedstawia i precyzyjnie objaśnia dorobek Potockiego w zakresie urzędowej opieki nad zabytkami Galicji Wschodniej, ze szczególnym uwzględnieniem zabytków Krosna i okolic. Pracę uzupełniają: aneks źródłowy, bibliografia, indeksy i streszczenie w języku angielskim.

Publikacja autorstwa Tadeusza Łopatkiewicza, owoc jego wieloletnich badań oraz poszukiwań archiwalnych i bibliotecznych, stanowi istotny przyczynek do nowej syntezy dziejów konserwatorstwa polskiego i ochrony zabytków na ziemiach Polski w XIX wieku. Elementem szczególnie cennym, odnalezionym przez autora książki i wykorzystanym pod kątem badanego miasta i jego okolic, jest Dziennik konserwatorski Potockiego, spisywany w latach 1866–1878, na kartach którego uwidaczniają się wszystkie blaski i cienie pracy ówczesnego konserwatora, znakomicie wydobyte i skomentowane przez Tadeusza Łopatkiewicza. Jest rzeczą konieczną, aby w najbliższym czasie źródło to zostało opublikowane i zinterpretowane w całości, najlepiej dzięki współpracy grona badaczy bliżej zajmujących się w ostatnim czasie osobą Ludwika Mieczysława Lubicz Potockiego, w tym Tadeusza Łopatkiewicza.
Wiersze
Authors: Tulik Jan
Published: February 2023

Wiersze poety krośnieńskiego Jana Tulika
Much to look forward to in 2023
Authors: Mather Linda
Published: February 2023

Linda Mather looks ahead to a day of professional recognition and learning at the British Association of Cosmetic Nurses' symposium, the celebratory Aesthetic Awards and a forthcoming law to protect patients by clamping down on poor practice—two cases of which she describes here
Krokodil Dergisinde Türk Devlet Adamları ile İlgili Karikatürlerin Görsel Retorik Analizi: 1922-1924
Authors: TEMİR Erkam
Published: February 2023

Bu çalışmada Mustafa Kemal Paşa, Sultan Vahdeddin ve Abdülmecid Efendi’nin Ağustos 1922-Nisan 1924 tarihleri arasında yayımlanmış Sovyet karikatürlerine nasıl yansıdığı SSCB’nin en eski ve ünlü siyasi mizah dergisi olan Krokodil dergisi örneğinde analiz edilmiştir. Makalede ilkin SSCB’de karikatürün propaganda amacıyla kullanımına değinilmiş ve Krokodil dergisi ile ilgili kronolojik bilgi sunulmuştur. SSCB’nin dönemin Türk-Sovyet ilişkilerindeki olumlu havaya uygun bir şekilde Ankara Hükümeti’nin destekçisi olması nedeniyle, ilgili karikatürlerde Mustafa Kemal Paşa’nın olumlu, Sultan Vahdeddin ve Abdülmecid Efendi’nin ise olumsuz temsil edildiği varsayılmıştır. Belirtilen zaman aralığında yayımlanmış karikatürler taranmış ve tespit edilen karikatürler görsel retorik analizi ile analiz edilerek varsayım sınanmıştır. Elde edilen bulgular doğrultusunda Krokodil dergisinde 1922-1924 yılları arasında yayımlanmış karikatürlerde Mustafa Kemal Paşa’nın olumlu, Sultan Vahdeddin ve Abdülmecid Efendi’nin ise olumsuz bir şekilde temsil edildiği doğrulanmıştır.