bluuebunny/crossref_metadata_2025 huggingface dataset:
The stories we tell victims: Victim participation and outreach programs at the extraordinary chambers in the courts of Cambodia
Authors: Destrooper Tine
Published: July 2018

Victim participation and elaborate outreach programs are becoming increasingly important features of international and hybrid criminal courts. The aspiration is that these programs will increase the local relevance of these courts' work, enhance the sustainability of justice processes after international actors leave, and empower victims en passant. In the last decade, considerable attention and resources have been dedicated to the development of state-of-the-art outreach and participation programs, resulting in exciting new engagement models that are then, on average, evaluated in legal and technical terms. So far, however, little attention has been paid to the more long-term and indirect effects of exposure to certain – unidimensional and hierarchically organized – narratives about justice. In a first step to systematically analyze this question, this article maps the discursive priorities and structure of one of the tribunals (Cambodia) where victim participation and outreach played a central role. The article uses innovative large-n qualitative computational text analysis methods and raises critical questions about (a) the disconnect between prosecutorial prioritization strategies and popular priorities for the justice process, (b) the success of outreach programs in bringing a locally relevant message, and (c) the extent to which outreach and victim participation succeeded in bridging the gap between the work of the ECCC and the realities of people on the ground.
Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography
Authors: Augustine Daniel X. , Coates-Bradshaw Lindsay D. , Willis James , Harkness Allan , Ring Liam , Grapsa Julia , Coghlan Gerry , Kaye Nikki , Oxborough David , Robinson Shaun , Sandoval Julie , Rana Bushra S. , Siva Anjana , Nihoyannopoulos Petros , Howard Luke S. , Fox Kevin , Bhattacharyya Sanjeev , Sharma Vishal , Steeds Richard P. , Mathew Thomas
Published: July 2018

Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg as confirmed on right heart catheterisation. Traditionally, the pulmonary arterial systolic pressure has been estimated on echo by utilising the simplified Bernoulli equation from the peak tricuspid regurgitant velocity and adding this to an estimate of right atrial pressure. Previous studies have demonstrated a correlation between this estimate of pulmonary arterial systolic pressure and that obtained from invasive measurement across a cohort of patients. However, for an individual patient significant overestimation and underestimation can occur and the levels of agreement between the two is poor. Recent guidance has suggested that echocardiographic assessment of pulmonary hypertension should be limited to determining the probability of pulmonary hypertension being present rather than estimating the pulmonary artery pressure. In those patients in whom the presence of pulmonary hypertension requires confirmation, this should be done with right heart catheterisation when indicated. This guideline protocol from the British Society of Echocardiography aims to outline a practical approach to assessing the probability of pulmonary hypertension using echocardiography and should be used in conjunction with the previously published minimum dataset for a standard transthoracic echocardiogram.
La acción sustantiva universitaria y la articulación con el entorno: caso Sede Regional Chorotega de la Universidad Nacional de Costa Rica
Authors: Suárez Serrano Andrea , Lezcano Calderón Sandra , Bautista Solís Pável
Published: July 2018

Recibido 30/01/2018     Aceptado 06/04/2018Se realizó una revisión de los proyectos de extensión-investigación de la Sede Regional Chorotega (SRCH) de la Universidad Nacional de Costa Rica para fortalecer la interrelación extensión-investigación-docencia y su articulación con la región. El objetivo de este trabajo es analizar cómo los proyectos de extensión e investigación influyen en la articulación interna y externa de la SRCH para cumplir con las diferentes actividades de la acción sustantiva universitaria. Se revisaron veintiocho proyectos de extensión-investigación, periodo 2012- 2017, utilizando un metaanálisis cualitativo y exploratorio de los proyectos registrados en el Sistema de Información Académica de la UNA. Los proyectos de extensión-investigación han fomentado una fuerte articulación de la UNA con comunidades y aliados estratégicos, ampliando el conocimiento de diversas disciplinas. Los proyectos permiten a las personas académicas mejorar su interacción y colaboración con organizaciones sociales, instituciones públicas y pares internacionales. Sin embargo, también es necesario revisar las políticas de regionalización para facilitar una mayor articulación con el sector privado y con otras universidades. Los fondos concursables regionales son esenciales para el desarrollo de proyectos de extensión e investigación. Sin estos recursos el alcance de las sedes regionales se reduciría drásticamente.
Visión de la extensión en Sedes Interuniversitarias, recomendaciones para la incorporación de acciones en zonas regionales. Eje: políticas de extensión. Sub-eje: orientaciones para las políticas de extensión en la Universidad Nacional
Authors: Miranda Benavides Karla , Prendas Aguilar Gaudy , Noguera Moya Scatk
Published: July 2018

Recibido 20/01/2018    Aceptado 30/03/2018El propósito de creación de las Sedes Interuniversitarias es desarrollar la acción sustantiva de la Universidad Nacional con participación de otras universidades públicas, lo cual representa una gran oportunidad para trasladar los resultados de la acción docente a las comunidades de las diversas zonas regionales. Este artículo expone la visión de un grupo de académicos en torno a la extensión universitaria en el ámbito de las Sedes; se describe el estado de la extensión en los planes de estudio de la Sede Interuniversitaria de Alajuela y se presenta un análisis de la normativa vigente respecto a la extensión. Además, se estudia un modelo de análisis administrativo y su aplicación en términos de una política de extensión. También se expone la importancia del trabajo con las comunidades en el ámbito de los programas de los cursos; tarea de la cual se desprenden recomendaciones para la ejecución de la extensión universitaria.
La formación profesional universitaria en extensión: una experiencia vivida
Authors: Vanegas Araya Jennifer Eunice
Published: July 2018

Recibido 7/2/2018   Aceptado 25/04/2018Este escrito pretende participar en el aporte que la extensión universitaria ofrece a la formación profesional, desde la experiencia vivida por parte de un grupo de estudiantes de distintas carreras de la Universidad Nacional ligados a un proyecto de extensión, todo en el aprender siendo, haciendo y sintiendo, junto a tres comunidades en condición de vulnerabilidad de Los Chiles de Alajuela. Analiza el aporte que emerge de la participación estudiantil en un proyecto de extensión para la resignificación de la formación profesional en la acción social inclusiva. La formación universitaria requiere una verdadera integralidad de saberes, promoviendo al estudiantado a la experiencia en el campo, espacio en el cual se pueden desarrollar competencias necesarias para la formación profesional desde acciones sociales. Se hace un llamado para que se evidencie en la extensión universitaria, la incorporación de la población estudiantil universitaria, haciendo un llamado a una formación más experimental, significativa y transformadora.
Planificación para el desarrollo con enfoque prospectivo en Bolivia, Ecuador, Guatemala y Perú
Authors: Sánchez Mercado Álvaro Cristian
Published: July 2018

La presente investigación realizauna exploración respecto de algunos conceptos ligados al Planeamiento Estratégico de un país, y, la comparación de los Sistemas de Planeamiento y los Planes Estratégicos de Desarrollo de Bolivia, Ecuador, Guatemala y Perú.Para ello, en una primera parte se ha hecho una revisión sistemática de las definiciones y en una segunda parte una revisión sistemática de los Sistemas de Planificación de los países en mención, desde el marco jurídico que lo ampara hasta su metodología de trabajo.Como resultado se ha podido observar que Guatemala es el único país que tiene definido un sistema de planificación ascendente y que ha definido metodologías de trabajo prospectivo desde los más bajos niveles. También se ha podido determinar que todos los países evaluados excepto Perú hacen una revalorización explicita de lo ancestral o indígena. Códigos JEL: O21, P11, P21, P41, R58.
Cuatro momentos económicos en la historia del Perú Republicano
Authors: Mendoza Vidal Jorge Américo
Published: July 2018

En casi 200 años de historia republicana, hemos pasado por cuatro momentos económicos. El primero corresponde al boom del guano, de 1830 hasta 1876. El segundo corresponde a la llamada República Aristocrática, período de 1894 a 1929. El tercero corresponde al boom exportador que vivimos luego del término de la Segunda Guerra Mundial, desde 1943 a 1976. El cuarto momento corresponde a los últimos 25 años de crecimiento económico mediante la aplicación de las políticas neoliberales. Se puede reconocer una tendencia en cada uno de estos. A partir de los datos dispersos el articulo tiene como objetivo analizar los momentos económicos que permite reconocer tanto las fases de auge como de caída. Se recoge estadística actualizada de investigaciones e información de especialistas en economía para historiar estos cuatro momentos. La particularidad de estos momentos es que previamente a la configuración de cada uno se debatía políticas proteccionistas y de industrialización versus posiciones liberales de diferentes matices: primero, Proteccionismo frente a Libre Comercio; después se propone industrialización, se continua con Liberalismo: “laisser faire”; luego Keynesianismo frente a neoliberalismo. Podemos afirmar que la historia económica republicana se ha desarrollado en cuatro momentos económicos claramente definidos. JEL: N16
Molecular identification of clinical isolates of Fusarium in Colombia
Authors: Gaviria-Rivera Adelaida Maria , Giraldo-López Alejandra , Santa-Cardona Carolina , Cano-Restrepo Luz
Published: July 2018

Objetivo Identificar aislamientos de Fusarium en pacientes con micosis por medio de las técnicas moleculares de PCR y secuenciación.Métodos Se tomaron 101 muestras de pacientes con micosis sintomática, entre los años 2004 y 2006. Para la detección de aislamientos como pertenecientes al género Fusarium, se amplificó parcialmente por PCR la región 28S del DNAr; y posteriormente —para la detección de la especie de Fusarium— se utilizaron cebadores específicos para F. oxysporum y F. solani. La verificación de la identidad de la especie de los aislamientos se hizo por secuenciación parcial de los genes 28S DNAr y TEF1-α.Resultados El total de 101 aislamientos fueron detectados como pertenecientes al género Fusarium utilizando un cebador universal de la region 28S DNAr; 52 y 29 aislamientos se detectaron como F. oxysporum o F. salani, respectivamente con los cebadores específicos, y la secuenciación parcial de los genes 28S rDNA o TEF1-α confirmó la identidad de las especies.Conclusión La secuenciación parcial del gen TEF1-α es aún el mejor marcador molecular para identificar aislamientos de Fusarium a nivel de especie. Sin embargo, en la mayoría de los casos es posible discriminar entre aislamientos de F. oxysporum y F. solani por PCR con cebadores específicos, lo que proporciona una ventaja importante considerando la simplicidad de la técnica y el rápido diagnóstico.
Terapia ocupacional en oncología: experiencias en prácticas académicas y revisión de literatura
Authors: Peñas-Felizzola Olga L. Peñas-Felizzola, Luz , Parra-Esquivel Eliana I. , Gómez-Galindo Ana M.
Published: July 2018

Objetivo Indagar sobre la formación de terapeutas ocupacionales en oncología en un programa universitario, e identificar literatura actualizada como evidencia para la formación y práctica profesional.Materiales y Métodos Estudio exploratorio transversal, con una muestra integrada por 29 estudiantes de terapia ocupacional de la Universidad Nacional de Colombia. Revisión sistemática de literatura 2010-2015, sobre intervenciones de terapia ocupacional en oncología.Resultados En la encuesta, menos de una cuarta parte de los estudiantes respondió haber recibido formación sobre manejo clínico de dicho diagnóstico, y sobre la intervención del terapeuta ocupacional con tales casos (24,1%). Poco más de dicho porcentaje (27,6%), ha tenido usuarios con cáncer en sus prácticas académicas. En la revisión de literatura no se encontraron publicaciones nacionales, aunque sí productos inéditos de universidades colombianas. Se recuperaron 54 trabajos internacionales, especialmente en rehabilitación, seguido de las áreas psicosocial y sociolaboral. El cuidado paliativo, la multidisciplinariedad, la experiencia subjetiva del paciente frente al diagnóstico y tratamiento, la atención humanizada e integral desde las diferentes áreas del quehacer terapéutico y el trabajo con cuidadores, se plantean como temas de relevancia profesional en el abordaje del paciente oncológico.Conclusiones Se aportan referentes para el desarrollo curricular de terapia ocupacional y para procesos de actualización profesional, de competencia de la academia y gremial. Es importante la intervención en cáncer no sólo durante, sino también mientras el tratamiento y posteriormente con supervivientes. Deben incentivarse las publicaciones profesionales, asegurando que arrojen evidencias potentes del impacto de la terapia ocupacional y de la rehabilitación oncológica.
Criptosporidiosis y «Una Salud»
Authors: Hernández-Gallo Nicolás , Hernández-Flórez Luis Jorge , Cortés-Vecino Jesús Alfredo
Published: July 2018

Criptosporidiosis es una enfermedad diarreica (zoonótica) causada por el parásito Cryptosporidium, el cual infecta al intestino. Se producen tanto en el ser humano como en diferentes animales de granja, mascotas y animales silvestres. Se subestima su papel y poco se conoce sobre su epidemiología, debido al escaso interés que suscita y la limitada disponibilidad de métodos de diagnóstico. La salud de las poblaciones tanto humana como animal, están relacionadas con una estrecha interacción de tres factores: el ambiente, los agentes patógenos, y las poblaciones, lo cual determina el estado de salud y enfermedad.El enfoque, conocido como «Una Salud», es una estrategia global en crecimiento que se está adoptando por una diversidad de organizaciones y responsables de las políticas en respuesta a la necesidad de enfoques integrados. Este enfoque puede ser relevante para una amplia gama de objetivos mundiales de desarrollo.Cada vez se habla más de salud integral, de salud holística. Parece que somos más conscientes de que la salud no se reduce a algo puramente biológico, sino que afecta a toda la persona. No es sólo ver al enfermo globalmente, es partir de la complejidad del ser humano y del mundo entero atravesado por la vulnerabilidad e interaccionar con la totalidad de los sujetos.
Comparison of polymerase chain reaction-restriction enzyme analysis method and DNA sequence analysis results in the identification of non-tuberculous mycobacteria
Authors: Appak Özgür , Türkel Selçuk , Esen Nuran , Özkütük Ayşe Aydan
Published: July 2018

The typing of non-tuberculous mycobacteria (NTM) is important from a clinical and epidemiological perspective. The polymerase chain reaction-restriction enzyme analysis (PRA) method and DNA sequence analysis method were utilized to target a gene region that codes the 65-kDa heat-shock protein for typing 150 suspected NTM samples isolated from the respiratory tract. Mycobacterium abscessus, Mycobacterium xenopi, Mycobacterium fortuitum, and Mycobacterium peregrinum were most frequently found by both methods. Six isolates that could not be defined by the PRA method were defined as Nocardia cyriacigeorgica, Nocardia abscessus, and Mycobacterium intracellulare by DNA sequence analysis. Discordance between the results of the two methods was observed for only one isolate. The isolate that was defined as Mycobacterium gordonae type 6 by the PRA method was defined as Mycobacterium senegalense by sequence analysis. The PRA method is simple and gives rapid results. Compared with DNA sequence analysis, it gives consistent and reliable results up to a ratio of 90%. DNA sequence analysis is the gold standard method in which all strains can be defined. However, given our laboratory conditions, its disadvantage is that it takes longer to reach a diagnosis than through the PRA method.
Characterization of macrolide-resistant non-invasive pneumococci in the pre-vaccine era in Serbia
Authors: Popovic Suncica , Hadnadjev Mirjana , Gajic Ina , Mijac Vera , Kekic Dusan , Smitran Aleksandra , Ranin Lazar , Opavski Natasa
Published: July 2018

Numerous reports have confirmed that increased macrolide use in the treatment of respiratory tract infection has contributed to the emergence of antibiotic resistance worldwide. Studies have also shown that pneumococcal vaccine can reduce pneumococcal resistance. The aim of this study was to determine the prevalence of co-resistance to penicillin and other antibiotics in macrolide-resistant (MR) non-invasive pneumococcal isolates and to evaluate serotype distribution in resistant strains in the pre-vaccine era in Serbia. About 80% of MR isolates expressed the MLS phenotype with very high resistance to both erythromycin and clindamycin. A total of 132 (84.1%) MR isolates were multiresistant, i.e., they were resistant to erythromycin, penicillin, tetracycline, and trimethoprim–sulfamethoxazole. Among 157 MR pneumococci, 11 different serotypes were found. Four serotypes, 19F, 14, 6B, and 23F, accounted for 77.7% of all MR pneumococcal isolates. Among isolates with the cMLS phenotype, serotypes 19F and 14 were predominant, whereas serotype 6A was the most common among those with the M phenotype, followed by 14. In conclusion, co-resistance to macrolides and penicillin in our non-invasive pneumococcal isolates is high. The majority of tested strains (∼80%) belonged to the four serotypes (19F, 14, 6B, and 23F) that are included in all conjugate vaccine formulations.
Image–Building
Authors: Greub Charlott
Published: July 2018

The aim of this paper is to examine the narratives of two films, Les Nuits Électriques by Eugène Deslaw (1928) and site specific_LAS VEGAS 05 by Olivio Barbieri (2005), using a favorite theme of avant-garde filmmakers: urban lighting in direct combination with neon light advertising.This paper offers a nuanced perspective on how film affects the understanding of neon advertising in relation to the built environment. Also, the paper explores the social, cultural, economic and political and conceptual implications of architecture as a sign through the interpretation of those who capture it.
Shaft resistance of pre-bored precast piles in Shanghai clay
Authors: Ling Zao , Wang Weidong , Wu Jiangbin , Huang Maosong , Yuan Juyun
Published: July 2018

Pre-bored precast piles with an enlarged base (PPEB piles) have been increasingly used in China over the past 5 years. However, the distributions of the shaft and toe resistance of the pile are still unclear. In order to reveal the ultimate bearing capacity and load transfer mechanism of PPEB piles in clay, three full-scale ultimate static loading tests were carried out in Shanghai. The test piles were instrumented with vibrating wire strain gauges to enable accurate measurement of the local shaft resistance along the pile shaft during the loading tests. The tests results revealed that about 75% of the pile bearing capacity was provided by shaft resistance when the ultimate load was applied and the majority of the shaft resistance was mobilised along the lower part of the test piles. After load testing, the soils around the test piles were excavated to evaluate the reliability and constructability of PPEB piles. The applicability of conventional methods (α-method and β-method) in estimating shaft resistance was assessed. In comparison with instrumented bored piles, the local shaft resistance of the PPEB piles in the lower stiff clays was significantly higher.
Early-age tensile creep and shrinkage-induced cracking in internally restrained concrete members
Authors: Khan Inamullah , Xu Tengfei , Castel Arnaud , Gilbert Raymond Ian
Published: July 2018

Experiments were carried out under ambient conditions and in a temperature–humidity control room to assess the influences of early-age shrinkage and tensile creep on cracking in reinforced-concrete (RC) members subjected to internal restraint. Two concrete mixes were considered, with compressive strengths of 36 MPa and 47 MPa. The evolution of the tensile creep coefficients was measured using unreinforced dog-bone-shaped specimens subjected to sustained axial tension. The shrinkage-induced stress tests were performed on RC prisms internally restrained by one concentrically placed reinforcement. Free shrinkage and restrained shrinkage were measured on companion plain concrete prisms and on unloaded RC prisms, respectively, to determine the degree of restraint. The results show that the 36 MPa concrete had a higher tensile creep coefficient than the 47 MPa concrete, but that there were no significant differences in early-age free shrinkage. A lower humidity results in more free shrinkage strain, but leads to more tensile creep and, consequently, increased relaxation of the tensile stresses. The magnitude of the restrained shrinkage depends on the reinforcement ratio. The development of the tensile strength of concrete is a governing factor influencing the time to cracking. The tensile ageing coefficient was calibrated for the two concrete mixes.
Unusual clinical presentation of Guillain Barre syndrome: a case report
Authors: Marenco Aristides , Lozada Juan Manuel
Published: July 2018

Background: Guillen barre syndrome is the most frequent cause of flaccid paralysis in the world, it is characterized by an acute demyelinating, autoimmune and multiple etiology polyneuropathy, among which are included infectious agents such as Campylobacter jejuni, Zika virus, of genetic and environmental factors.

Case Report: We present the case of a 56-year-old Colombian male patient with a history of hypertension, who entered the intensive care unit with symptoms of atypical asymmetric motor neurological compromise, which rapidly progressed to ventilatory failure and subsequent confinement síndrome.

Discussion: Guillen barre síndrome establishes a potentially fatal disease, the semiology of pain, paresthesia, symmetric-progressive, distal weakness, instability, hipo/areflexia, constitute a neurological emergency. There are Clinical variants establishing a great.
Developing a socially transformative focus in Occupational Therapy: insights from South African practice
Authors: RichardsI Leigh-Ann , Galvaan Roshan
Published: July 2018

Social and political contexts are known to influence people's opportunities to engage in occupations. Occupational therapy in the domain of community development practice addresses the social determinants of health by contributing towards social transformation. Socially IH transformative practice refers to occupational therapy practice that strives to and addresses the social determinants of health and social Π I injustice through drawing on critical perspectives. Educators applied an autobiographical form of study, data were generated firstly through keeping a written reflective journal and audio recorded reflections on practice. Secondly, written comments and feedback to students ~\ during their community development practice placements were also included in the data set. Data were thematically analysed, yielding (/) I a theme and two categories. The theme: Towards socially responsive practice revealed the value of adopting a critical and collaborative approach to practicing occupational therapy in various domains of practice. Working towards social transformation was demonstrated as possible through the categories of being able to See and Feel the invisible and enabled as Equals working for change. The findings suggest that critical reflexivity together with implementation of participatory practices are necessary requirements towards addressing the conditions of people's health and occupational well-being. Key words: Occupational therapy practice; social transformation; participatory practice; Occupation-based community development
Occupational therapy students' experiences and perceptions of culture during fieldwork education
Authors: Sonn Inge , Vermeulen Nikki
Published: July 2018

BACKGROUND: Understanding a client's culture allows practitioners to consider the planning of intervention and allows for a client centred approach to be provided. During fieldwork education occupational therapy students can face the challenge of other cultural practices, standards, morals and ways of life coming into conflict with their own. PURPOSE: There is minimal South African literature discussing the challenges and supporting factors that assist students in becoming culturally competent across cross-cultural settings. This article explored occupational therapy students' experiences of culture, and their perceptions of the barriers and enablers that culture presents during fieldwork education. METHODS: A qualitative study was conducted with undergraduate occupational therapy students from a university in Cape Town, South Africa. Data were collected using focus groups with each group of students from first to fourth year and were analysed using thematic analysis. FINDINGS: The two main themes that emerged from the analysis, were: 1) "Culture is easily defined but not easily described", which focuses on the students own understandings and interpretations of culture, and 2) "Is there no 'me' in OT?" which specifically describes students' experiences of culture during fieldwork practice. IMPLICATIONS: The findings of this study questioned whether cultural competence is static but determined that exposure to, positive attitudes towards and self-reflection on culturally diverse experiences are the factors that contribute towards developing cultural competence in culturally diverse situations. Key words: Occupational therapy; Students; Culture; Cultural Competence; Cultural Sensitivity; Acculturalization; Fieldwork Education
Size of foreign direct investment and firm characteristics
Authors: Veronika Hecht , Michael Moritz , Patricia Noska , Johannes Schäffler
Published: July 2018

This paper focuses on the role of classifying types of foreign direct investment (FDI) for analysing the determinants of cross-border investment relationships. We base our investigation on a newly established firm-level data set of German multinational firms and their affiliates in the Czech Republic that allows various categorisations into vertical foreign direct investment (VFDI) and horizontal foreign direct investment (HFDI). Apart from data for conventional approaches to classifying FDI types, the surveyed information contained herein also includes a detailed self-assessment of the firms with respect to investment motives, and specifications on intra-firm trade and the flow of intermediate inputs. In order to correct for sample selection, we apply a two-step Heckman procedure by comparing multinational firms that have an affiliate in the Czech Republic to companies without investment abroad. The results for the direct measures of FDI types confirm theoretical expectations and previous empirical literature and stand in marked contrast to the outcome for indirect measurement concepts. Our finding leads us to the conclusion that one should be more cautious in interpreting differences between vertical and horizontal FDI when using approximative classification concepts.
Transformation of Synechoccus sp PCC7002 v1
Authors: Vogel Anne , RL Lale Rahmi , Hohmann-Marriott Martin
Published: July 2018

This protocol describes the transformation of Synechococcus sp. PCC7002 with linear DNA fragments with homologous regions.
Methylated DNA immunoprecipitation combined with microarray (MeDIP-chip) v2
Authors: Wang Juan
Published: July 2018

Background: Aberrant DNA methylation occurs frequently in cancer. The aim of this study was to identify novel methylation markers in lung cancer in Xuanwei, China, through integrated genome-wide DNA methylation and gene expression studies. Methods: Differentially methylated regions (DMRs) and differentially expressed genes (DEGs) were detected on 10 paired lung cancer tissues and noncancerous lung tissues by methylated DNA immunoprecipitation combined with microarray (MeDIP-chip) and gene expression microarray analyses, respectively. Integrated analysis of DMRs and DEGs was performed to screen out candidate methylation-related genes. Both methylation and expression changes of the candidate genes were further validated and analyzed. Results: Compared with normal lung tissues, lung cancer tissues expressed a total of 6,899 DMRs, including 5,788 hypermethylated regions and 1,111 hypomethylated regions. Integrated analysis of DMRs and DEGs identified 45 tumor-specific candidate genes: 38 genes whose DMRs were hypermethylated and expression was downregulated, and 7 genes whose DMRs were hypomethylated and expression was upregulated. The methylation and expression validation results identified 4 candidate genes (STXBP6, BCL6B, FZD10, and HSPB6) that were significantly hypermethylated and downregulated in most of the tumor tissues compared with the noncancerous lung tissues. Conclusions: This integrated analysis of genome-wide DNA methylation and gene expression in lung cancer in Xuanwei revealed several genes regulated by promoter methylation that have not been described in lung cancer before. These results provide new insight into the carcinogenesis of lung cancer in Xuanwei and represent promising new diagnostic and therapeutic targets.
ISOLATION OF MONONUCLEAR CELLS (PBMC) BY GRADIENT CENTRIFUGATION v1
Authors: known Not
Published: July 2018

Protocol with Ficoll-Paque/Histopaque for isolation of PBMCs from heparinized blood
STUDENTS’ ASSESSMENT OF THEIR PROFESSIONAL PERSPECTIVES ON THE LABOR MARKET
Authors: GANINA O. A. , SELETKOVA G. I. , FEDOTOVA V. A.
Published: July 2018

Stable reproduction of resources in the labor market, as well as their  adaptation to current trends, largely depend on the awareness  of potential employees of their capabilities and prospects. Such views are formed already at the initial stages of mastering the  profession - in obtaining higher education. These representations are  an important indicator especially in the context of the  transformation of the higher education system, in particular in  connection with the updated GEF HE. In this article, the authors  consider approaches to studying the youth labor market and focus  their attention on issues of professional self-determination and  gaining experience in labor activity. Based on the focus group study,  the authors disclose the expectations and self-assessments of  students regarding their professional prospects in the labor market. Researchers identify specific features of selfassessment of  professional perspectives depending on the course of study, on the  level of professional education and other factors. As it turned out,  undergrads tend to assess the degree of their readiness to enter the  labor market rather high, but nevertheless feel undefined. According  to the students, frequent short-term internships in specific  enterprises could increase their confidence and expand the prospects  for successful employment. At the same time, students  are more focused on working in specific organizations than actually  on professional self-actualization.
LIFE AFTER REFORMS: THE SURVIVAL PRACTICES IN THE RUSSIAN FAR EAST AT THE TURN OF XX-XXI CENTURIES IN THE MIRROR OF FICTION
Authors: VOLKOVA E. S.
Published: July 2018

Following the current trends in the development of historical science,  the author considers fiction as an important source for the  study of the post-Soviet period, allowing recreating the socio- historical types of behavior, way of thinking and public mood, to  track the transformation of the structures of everyday life. The  article is based on the fiction published from the early 1990s to the  present day and reflected the Far Eastern realities of the 1990s-2000s. The main attention is paid to the ways of adaptation to the  new socio-economic conditions, such as inflation and the fall in real  money incomes, massive cuts and wage delays, privatization, the collapse of industrial enterprises, the destruction of social  infrastructure, the income differentiation, and an increasing gap  between more and less developed territories. Art works show how in  crisis the Far East inhabitants are looking for opportunities for part- time work, change professions, working for hire, opening their own  business or falling into the category of self-employed, use deviant  and destructive forms of employment. Many people in the conditions  of continuous growth of prices, delays in wages or lack of a  permanent, well-paid place of work are accustomed to live without  money, making purchases rarely, but using subsistence farming in  dacha or vegetable garden, the interchange of goods and services,  engaged in gathering, hunting, fishing (the aboriginal population  returns to traditional marine mammal hunting). In addition, the Far  East inhabitants react to the modified conditions by changing their  demographic behavior. Horizontal public relations are being  strengthened, mutual assistance are widely used in the circle of relatives and friends.
FAR EAST DEVELOPMENT STRATEGY: (NOT) TYPICAL CASE OF MODERN RUSSIAN REGIONAL POLICY
Authors: PESTSOV S. K. , VOLYNCHUK A. B.
Published: July 2018

The main subject of the research in this article is the development  policy of the Far East as one of the aspects (components) of the  strategy of pivot to the East, declared and implemented by the  country's leadership from the beginning of the 2000s. The case of  Russian policy related to the development of the Far East has a  scientific and practical interest in two respects. On the one hand, as  a means of ensuring success in Russia's general pass to Asia, on the other, as an example, allowing judging the content, basic  approaches and principles of modern Russian regional policy as a  whole. The main features and peculiarities of this policy are  considered by the authors in the context of the discussion about the so-called new paradigm of regional policy that is unfolding in  recent years. The article analyzes the strengths and weaknesses of  the new regional policy, and evaluates its effectiveness.
Canopy River - medio ambiente, sociedad y rentabilidad: un equilibrio estratégico en la empresa turística rural
Authors: Lozano Jiménez Israel , Domínguez Aguirre Luis Roberto , Robles Cibrián Hugo Alberto , Ramírez Campos Álvaro Fabricio
Published: July 2018

El presente caso de estudio muestra la combinación de estrategias de negocios fundamentadas en el cuidado del entorno y beneficio social, que la compañía Canopy River ha utilizado para la generación de utilidades en el contexto del turismo de aventura. La estrategia de investigación para el estudio incluyó entrevistas en profundidad, revisión documental, observación y la interacción con la comunidad de la organización para identificar las acciones realizadas entre el 2007 y 2016. Los resultados muestran las características generales de la organización y las de su ambiente, las medidas estratégicas de rentabilidad y crecimiento, cuidado ambiental y contribución social, así como razonamientos respectivos del caso que dan cuenta del equilibrio entre los elementos estratégicos observados.
Obtaining of Biologically Soluble Membranes Based on Polymeric Nanofibres and Hydroxyapatite of Calcium
Authors: Daulbayev Ch. , Mansurov Z. , Mitchell G. , Zakhidov A.
Published: July 2018

In this paper, the possibility of obtaining a synthetic hydroxyapatite of calcium from a biological waste material is shown. The characteristics influencing the synthesis process are studied. Based on the results of the X-ray analysis and the obtained electron microscope images, it can be concluded that the synthesized HAP has a Ca/P ratio of 1.5 and with crystals with an average size of 2 microns. In work, experiments on obtaining biologically soluble films based on nanoscale polymer fibers and calcium hydroxyapatite were carried out. As a result, the main parameters of the process for the electroforming of nano-sized fibers with HAP are determined. The proposed method allows the laying of strictly directed nanofibers from a polymer with a diameter of 50 to 500 nm. The use of different types of electrodes makes it possible to vary the size of nanofibers. The characteristics such as solution viscosity, high voltage and optimum parameters were selected, which allowed obtaining films from biologically soluble polymer nanofibers and HAP. Also, experiments were conducted to introduce medicines into the film structure.
Dry Reforming of Methane on Carriers and Oxide Catalysts to Synthesis-Gas
Authors: Dossumov K. , Yergaziyeva Y. , Myltykbayeva L. , Telbayeva M.
Published: July 2018

The catalytic activity of carriers: θ‒Al2O3, γ‒Al2O3, 5A, 4A, 3A and 13X and the oxides of metals of variable valency ‒ NiO, La2O3, CuO, MoO3, MgO, V2O5, WO3, CoO, Cr2O3, ZnO, ZrO2, CeO2, Fe2O3, supported on the effective carrier γ‒Al2O3 by the method of capillary impregnation of the support with solutions of nitric salts of metals were investigated in the process of carbon dioxide conversion of methane (DRM). The optimal technological regimes for the process were: the reaction temperature -800 °C, the space velocity of the initial reactants ‒ 1500 h-1 with a methane to carbon dioxide ratio equal to 1. It was found that among the studied catalysts the highest activity is shown by the NiO/γ‒Al2O3 catalyst, where the yields of hydrogen and carbon monoxide reaches 45.4 and 42.4% by volume, respectively, when methane conversion is 89%. The XRF method showed that the content of alumina and nickel oxide after the reaction remained unchanged at 96.7 and 3.0%, respectively. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), small angle X-ray scattering (XRS) determined that nickel-containing NiO/γ‒Al2O3 catalyst form nickel nanoparticles (6.4‒10 and 50‒150 nm) and a uniform their distribution on the surface of the carrier takes place. These physical chemical characteristics have a positive effect on the activity of NiO/γ‒Al2O3 catalyst in the process of carbon dioxide conversion of methane to synthesis gas.
NMR-Spectroscopy Determination of Fragmentary Composition of Bitumen and its Components
Authors: Teltayev B. , Seilkhanov T.
Published: July 2018

This paper represents and discusses the results of quantitative determination for fragmentary composition of road bitumen of grade BND 100/130 and its components (asphaltenes, resins and oils) by NMR spectroscopy method. Group chemical composition of the bitumen has been determined by adsorption chromatography method. It has been identified that the bitumen and its components consist only of aromatic and aliphatic protons, which account for 2.4‒10.2% and 9.8‒97.6% respectively. Availability of olefinic elements in them has not been identified. The most part (79‒81%) of nuclei of carbon atoms relates to quaternary carbon atoms of saturated compounds. Primary carbon atoms at methylene group (CH2) are contained in the least quantity: bitumen ‒ 1.32%; asphaltenes – 0.6%; resins – 3.24% and oils – 2.11%. Primary carbon atoms, linked with CH-group or aromatic nucleus, occupy an intermediate position and are contained in the quantity of 17‒20%.
Composition and
Authors: Ved’ M. , Sakhnenko N. , Yermolenko I. , Yar-Mukhamedova G. , Atchibayev R.
Published: July 2018

Principles of three component Iron-Cobalt-Tungsten alloys electrodeposition from complex Fe (III) based citrate electrolytes are discussed. It is shown, that deposition of ternary alloys proceeds through competitive reduction of cobalt and tungsten with iron. With increasing ligand concentration coatings are enriched with a refractory component; however, increasing current density favors a reverse trend. The effect of both current density and pulse on/off time on the quality, content of alloying metals and surface topography of electrolytic coatings were determined. The application of pulsed electrolysis provides increasing tungsten content up to 13 at.%, at current efficiency of 70–75%. Globular relief of Fe-Co-W coatings is caused by refractory metals incorporation, and crystalline and amorphous parts of structure are visualized by X-ray spectroscopy, including inter-metallic phases Co7W6, Fe7W6 along with α-Fe and Fe3C. The crystallite size of the amorphous part is near 7–8 nm. Corrosion resistance of the coatings is 1.3–2.0 orders of magnitude higher than the substrate parameters as follows from data of polarization resistance method and electrode impedance spectroscopy.
Feeding preference of three Collembola species on two plant residues
Authors: Seres Anikó , Szakálas Judit , Boros Gergely , Ónodi Gábor , Kröel-Dulay György , Nagy Péter
Published: July 2018

This study formed the part of an extended climate change experiment that focuses on the ways climate change may affect the species composition and the ecological processes of vulnerable open sand grasslands. The project is conducted in a natural shrubland-grassland ecosystem in the Kiskunság National Park. This is an arid area, and the members of macrofauna are almost completely lacking from these soils. Collembola presumably plays an important role in the direct decomposition processes, beyond the indirect regulation of the microbiota. Previously, we found a higher decomposition rate for grass leaves as compared to grass roots and faster decomposition of one dominant grass species (Festuca vaginata) over the other (Stipa borysthenica) in this experimental system. In the present study, we investigated in a laboratory experiment, whether higher decomposition rate may be related to food preference of potential decomposer species in the system, and posed the following questions: (i) is there a preference in the food choice of three springtails species (Folsomia fimetaria, F. candida, Sinella magyari) between the roots and leaves of the two dominant plant species (Stipa borythenica, Festuca vaginata) and between the roots and leaves of the same species? (ii) can the C/N ratio and lignin content of plants as background variable explain such preference? Significant differences were found in the food preference of all Collembola species between the two parts of the plants and in some case between the two plant species. The leaves and Festuca vaginata were more preferred food type as compared to roots and Stipa borysthenica. The chemical composition of the plant parts well explained the observed patterns, especially the N and lignin content of the leaves and roots.
Synthesis and Characterization of Jeffamine Core PAMAM Dendrimer-Silver Nanocomposites (Ag JCPDNCs) and Their Evaluation in The Reduction of 4-Nitrophenol
Authors: GÜRBÜZ Mustafa Ulvi , ERTÜRK Ali Serol
Published: July 2018

This paper presents the synthesis,
characterization and catalytic evaluation of Jeffamine core PAMAM
dendrimer-silver nanocomposites (Ag JCPDNCs). Generation-4 Jeffamine core PAMAM
dendrimer (JCPD or P4.NH2) was used as the stabilizing templating
agent for the synthesis of Ag-JCPDNCs. Characterization of the synthesized Ag
JCPDNC was performed by UV visible (UV-Vis) spectroscopy and high resolution
transmission electron microscopy (HRTEM). The catalytic activity of dendrimer
nanocomposite (DNC) was assessed on the reduction of 4-nitrophenol (4-NP) to 4
aminophenol (4-AMP) in the presence of sodium borohydride (NaBH4) as
reducing agent by monitoring the conversion at λ 400 nm. The prepared Ag
JCPDNCs displayed a good catalytic activity (K = 0.12 x 10-2 s-1)
for the model reduction reaction of 4-NP with the particle size distribution of
4.72 ± 0.81 nm, which offer
a mixed type (interior and exterior) of DNC formation. The Ag JCPDNCs can be a
valid complete alternative to their existing candidates in the literature with
their different polymeric organics components and be great potential for the
future studies as new materials.
Organoleptic, physiochemical and microbiological qualities of dried fish, tengra (Mystus tengara) with different levels of salt and turmeric powder
Authors: Jakhar J. K. , Vardia H. K. , Chandravanshi Neelmani , Painkra Rohit Kumar , Mir Shabir , Masood Danish
Published: July 2018

Fresh tengra fish (Mystus tengara) samples were collected from fish market, Kawardha and different levels of salt and turmeric powder were added (0% salt and 0% turmeric powder, T0; 2% salt with 0.2% turmeric, T1; 4% salt with 0.2% turmeric, T2; 8% salt with 0% turmeric powder, T3 and 12% salt with 0% turmeric powder, T4). The processed and salted fish were dried in hot air oven at 60°C for 20 hours. Carcass yield (%), salt content (%), pH and moisture content of cured fish were respectively 39.06 - 43.87%, 3.15 - 4.59%, 6.52- 6.90 and 4.91 – 6.84 %. The sensory assessment showed that treatment T2 had the highest score for texture 5.70; appearance 8.30, odor 8.02 and taste 8.05 while T0 and T1 had least sensory scores. Aerobic plate count of various treatments were found significantly different (p Lass Than 0.05) with the lowest in treatment T4 (3.3 x 103 cfu/g) followed by treatment T2 (3.7 x 103 cfu/g) and highest in treatment T0 (5.4 x 103 cfu/g). Tengra fish cured with 4% salt and 0.2% turmeric powder (T2) found to be the best in yield, microbial load and sensory attributes. The dry salted fish processed with low level of salt and turmeric powder are best for human consumption, particularly for the patients of blood pressure and diabetes.Therefore, preparation of dried products from low-cost fish will help in increasing the employment opportunities and also reduce post-harvest losses.
A comparative analysis of microscopy and PCR based detection methods for Babesia and Trypanosoma infecting bovines and assessment of risk factors
Authors: Maharana B. R. , Kumar B. , Joseph J. P. , Patbandha T. K.
Published: July 2018

The present study was carried out to evaluate and compare the status of infection and assessment of risk factors in 353 blood samples (144 cattle and 209 buffaloes) of bovines by PCR assay along with microscopic examinations (ME). ME revealed prevalence of Babesia bigemina and Trypanosoma evansi to be 22.91% and 0.69%, respectively in cattle and 12.44% and 0.95%, respectively in buffaloes. Conversely, PCR assay was able to detect 40.97% and 3.47 % prevalence of B. bigemina and T. evansi in cattle and 23.92% and 6.69% in buffaloes, respectively. The result revealed that the PCR assay was 100% sensitive and 82.9% specific when compared with ME for babesiosis and 100% sensitive and 95.42% specific for trypanosomosis. Multivariate logistic regression models showed that risk of babesiosis was significantly higher in cattle (Odds ratio (OR) =2.207, P=0.001) compared to buffaloes. The risk for surra in male buffaloes increased by 6.37 times (OR= 6.375, P=0.013). Conversely, risk of babesiosis was significantly lower in male cattle than females (OR= 0.467, P=0.044).