bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of local wind and spatial conditions on geometry blade of wind turbine
Authors: Woźniak Agnieszka , Kluczek Aldona , Ślusarczyk Bogusław , Żegleń Patrycja , Górka Małgorzata
Published: June 2024

The research addresses the pressing need to understand wind conditions for optimal wind energy utilization, a crucial aspect of achieving global energy sustainability. While previous studies have focused on assessing wind energy potential and terrain roughness, gaps persist in understanding how wind and spatial conditions affect blade geometry. Therefore, this study aims to investigate the impact of local wind conditions on wind turbine blade geometry, integrating nonuniform wind inflow due to wind shear into the theoretical model. Through the paper, it explores blade design for varying inflow conditions and analyses the relationship between terrain type and blade designs. A novel approach to wind turbine blade design, utilizing a theoretical model that combines the local momentum theorem with insights from propeller vortex theory was adopted. Through the analysis, the authors demonstrate that variations in terrain significantly influence blade geometry, underscoring the necessity for tailored turbine designs based on local conditions. The findings reveal discrepancies in blade geometry across different turbine capacities and terrain types, offering novel insights into wind turbine performance optimization. By tailoring blade geometry to specific locations enhances resource utilization, offering insights for energy policymakers. The research provides validated methods for optimizing turbine geometric parameters, opening avenues for increased local investment in wind energy and promoting distributed energy development. Illustrated with wind plants examples, the paper concludes by outlining future research directions in this field.
Biochemical characterization of mulberry (Morus spp.) genotypes from the Türkiye (Hizan, Bitlis): A comprehensive analysis of fruit properties and bioactive compounds
Authors: Uyak Cuneyt , Aglar Erdal , Ozturk Burhan , Doğan Adnan , Tekin Onur
Published: June 2024

The present study was carried out to assess the fruit traits and phytochemical properties of 39 mulberry genotypes [Morus alba L. (16 white mulberry), Morus rubra L. (11 red mulberry), and Morus nigra L. (12 black mulberry)] selected in Bitlis province (Hizan) of Türkiye. Approximately, 1 kg fruit were hand‐harvested from each genotype. The fruit size, fruit color, pH, titratable acidity, soluble solids content (SSC), vitamin C, total phenolics, total flavonoids, antioxidant activity, and individual phenolic compounds were determined. The fruit weight varied between 1.80 and 5.84 g in black mulberry, 1.22 and 4.18 g in red mulberry, and 1.29 and 3.10 g in white mulberry. In white mulberry, SSC was determined to be between 19.00% and 38.86%, and in black and red mulberry it was between 11.86% and 21.90% and 12.60% and 18.90%, respectively. The titratable acidity rate, which varied depending on the species, was lower in white mulberry, but the highest acidity rate was recorded in red mulberry. Vitamin C was determined as 33.13 mg 100 g−1 in red mulberry, 24.10 mg 100 g−1 in black mulberry, and 14.03 mg 100 g−1 in white mulberry. Total phenolics in mulberries varied depending on the species, and the red mulberry fruit contained higher phenolic substances, followed by black and white mulberries. The total flavonoids varied between 0.27 and 7.83 g QE kg−1, whereas the flavonoids varied depending on the species and genotype. The highest values in terms of bioactive compounds were recorded in fruits of the 13HZN23 and 37 genotypes. Black and red mulberry fruit were found to have higher levels of individual phenolic content than the white mulberrry fruit.
Extruded canine diets containing primarily peas in contrast to those containing lamb and chicken meal are at higher risk of mold and mycotoxin contamination when treated similarly: An observational study
Authors: Crosbie Michelina , Pezzali Julia G. , Hancock‐Monroe Leslie , Buff Preston R. , Shoveller Anna K.
Published: June 2024

Three extruded dog diets were created for a nutritional study with different primary protein sources (BAS: lamb meal (LM) and deboned lamb (DL); CHK: chicken meal, LM, and DL; PEA: dried ground pea, LM, and DL). All diets were processed using the same single‐screw extruder, shipped from the processing facility on the same day, and transported under the same conditions in January 2021. After 8 months of storage in a temperature and humidity‐controlled room in September 2021, only the PEA diet was molded upon inspection. Mold and mycotoxin analysis of all diets was conducted in both September 2021 and at expiry in January 2022, which confirmed mold and mycotoxin contamination to some degree in all diets and most pronounced in the PEA diet across both timepoints. Nutrient analysis of all diets was conducted at production and 2 months post‐expiry in March 2022. As expected, fatty acid and vitamin contents of all diets decreased between sampling timepoints, and amino acid contents generally remained stable. Methionine decreased by 14% in CHK, cystine decreased by 15% and 20% in CHK and PEA, respectively, tyrosine decreased by 30%, 25%, and 27% across BAS, CHK, and PEA, respectively, and taurine decreased by 50%, 42%, and 55% across BAS, CHK, and PEA, respectively. Inaccurate measurement of the PEA diet moisture content post‐production likely led to mold development which may also negatively impact the availability of nutrients and could put dogs at risk for mycotoxicosis and nutrient deficiencies if not closely monitored, but controlled studies are required.
Hierarchical joint analysis of marginal summary statistics—Part II: High‐dimensional instrumental analysis of omics data
Authors: Jiang Lai , Shen Jiayi , Darst Burcu F. , Haiman Christopher A. , Mancuso Nicholas , Conti David V.
Published: June 2024

Instrumental variable (IV) analysis has been widely applied in epidemiology to infer causal relationships using observational data. Genetic variants can also be viewed as valid IVs in Mendelian randomization and transcriptome‐wide association studies. However, most multivariate IV approaches cannot scale to high‐throughput experimental data. Here, we leverage the flexibility of our previous work, a hierarchical model that jointly analyzes marginal summary statistics (hJAM), to a scalable framework (SHA‐JAM) that can be applied to a large number of intermediates and a large number of correlated genetic variants—situations often encountered in modern experiments leveraging omic technologies. SHA‐JAM aims to estimate the conditional effect for high‐dimensional risk factors on an outcome by incorporating estimates from association analyses of single‐nucleotide polymorphism (SNP)‐intermediate or SNP‐gene expression as prior information in a hierarchical model. Results from extensive simulation studies demonstrate that SHA‐JAM yields a higher area under the receiver operating characteristics curve (AUC), a lower mean‐squared error of the estimates, and a much faster computation speed, compared to an existing approach for similar analyses. In two applied examples for prostate cancer, we investigated metabolite and transcriptome associations, respectively, using summary statistics from a GWAS for prostate cancer with more than 140,000 men and high dimensional publicly available summary data for metabolites and transcriptomes.
Implementing a COVID‐19 vaccination outreach service for people experiencing homelessness
Authors: Hollingdrake Olivia , Grech Elizabeth , Papas Leanne , Currie Jane
Published: June 2024

Issue Addressed

In 2021, the Australian government implemented a population wide COVID‐19 vaccination program. People experiencing homelessness faced challenges accessing vaccines and many were not being reached. By reorienting vaccination services to include assertive outreach strategies, a Brisbane‐based non‐profit health care team successfully administered 2065 COVID‐19 vaccinations to homeless and precariously housed people. This study examines insights from stakeholders delivering the service and perspectives of clients who received a vaccine.

Methods

Semi‐structured interviews with five stakeholders and a survey of 63 clients involved in the Micah Projects COVID‐19 vaccination program are reported. Client survey questions covered demographic characteristics, and motivations and hesitancies around vaccination. Stakeholder interviews were inductively analysed and quantitative survey data were exported into SPSS (IBM V27) and analysed using descriptive statistics.

Results

The Micah Projects team initiated 220 pop‐up vaccination clinics and worked closely with Aboriginal and Torres Strait Islander communities. Downsizing and mobilising the service engaged greater numbers of people sleeping rough and Aboriginal and Torres Strait Islander people. Clients' decisions to vaccinate were often spontaneous, driven by immediate availability and motivated by a desire to stay healthy and protect the community.

Conclusions

Tailoring vaccination programs to include assertive outreach strategies effectively reduces barriers for people experiencing homelessness. Community embeddedness, trust, flexibility and cultural safety are critical elements for success.

So What?

People experiencing homelessness are motivated to vaccinate. Reorientating health services to remove structural barriers and build the supportive environments needed to work through vaccine hesitancies are critical elements to ensure equitable access and promote health.
Effects of computerized cognitive training on biomarker responses in older adults with mild cognitive impairment: A scoping review
Authors: Hayashi Hiroshi , Sone Toshimasa , Iokawa Kazuaki , Sumigawa Koshi , Fujita Takaaki , Kawamata Hironori , Asao Akihiko , Kawasaki Iori , Ogasawara Maki , Kawakatsu Shinobu
Published: June 2024

Background and Aims

Mild cognitive impairment (MCI) is a widespread condition in older individuals, posing significant risk of dementia. However, limited research has been conducted to explore effective interventions and clarify their impact at the neural level. Therefore, this study aimed to investigate the effects of computerized cognitive training (CCT) and explore the associated neural mechanisms in preventing dementia in older individuals with MCI, with a view to inform future intervention efforts.

Methods

We reviewed the effects of CCT on biomarker outcomes in older adults with MCI. The search was conducted for studies published between 2010 and May 10, 2023, using three search engines: PubMed, Scopus, and Cumulative Index to Nursing and Allied Health Literature. The inclusion criteria were as follows: studies that involved participants diagnosed with MCI, included CCT, included quantitative assessment of biomarker results, and conducted randomized controlled trials.

Results

Sixteen studies that used biomarkers, including magnetic resonance imaging, electroencephalography (EEG), functional near‐infrared spectroscopy (fNIRS), and blood or salivary biomarkers, were extracted. The results showed that CCT caused changes in structure and function within the main brain network, including the default mode network, and decreased both theta rhythm activity on EEG and prefrontal activity on fNIRS, with improvement in cognitive function. Furthermore, CCT combined with physical exercise showed more significant structural and functional changes in extensive brain regions compared with CCT alone. Virtual reality‐based cognitive training improved not only executive function but also instrumental activities of daily living.

Conclusion

CCT causes functional and structural changes in extensive brain regions and improves cognitive function in older adults with MCI. Our findings highlight the potential of individualized intervention methods and biomarker assessment according to the specific causes of MCI. Future research should aim to optimize these personalized therapeutic strategies to maximize the benefits of CCT in older adults with MCI.
Awareness of stroke, its signs, and risk factors: A cross‐sectional population‐based survey in Ghana
Authors: Attakorah Joseph , Mensah Kofi Boamah , Yamoah Peter , Bangalee Varsha , Oosthuizen Frasia
Published: June 2024

Background and Aims

The prevalence of stroke in sub‐Saharan Africa is steadily rising, leading to a growing strain on the healthcare system in the region. In the context of Ghana, stroke ranks as the third most prevalent cause of mortality. The current body of scholarly research on stroke awareness in Ghana is quite limited. The aim of this study is to assess the level of awareness of stroke, as well as its signs and symptoms among the Ghanaian population.

Methods

The study employed a cross‐sectional quantitative methodology, wherein 1000 participants completed self‐administered structured questionnaires. Descriptive statistics were utilized to summarize the participants' socio‐demographic characteristics and their responses. To assess the relationship between participants' sociodemographic traits and their awareness of stroke signs, symptoms, risk factors, and perception, the Chi‐square test of independence was conducted using IBM SPSS version 26. A significance level of p < 0.05 was established.

Results

The study identified limited awareness regarding stroke symptoms, warning signs, and risk factors. The participants exhibited an overall knowledge range of 25.9% to 47.2% concerning stroke signs and symptoms, and a range of 24%–39% regarding its causes and risk factors. Notably, paralysis (70.8%) and diet (59.9%) were the most easily recognized warning signs and risk factors for stroke, respectively. Sociodemographic characteristics such as age, religion, educational status, exposure to stroke, employment status, and marital status were shown to be associated with participants knowledge of stroke (p < 0.05).

Conclusion

The study's results indicated a widespread lack of knowledge concerning the causes and risk factors of stroke among the Ghanaian population, highlighting the necessity for increased public education efforts to raise awareness about this condition.
Identification of hub genes and pathways in hepatitis B virus‐associated hepatocellular carcinoma: A comprehensive in silico study
Authors: Kalaki Niloufar Sadat , Ahmadzadeh Mozhgan , Mansouri Atena , Saberiyan Mohammadreza , Karbalaie Niya Mohammad Hadi
Published: June 2024

Background and Aim

The hepatitis B virus (HBV) is one of the most common causes of liver cancer in the world. This study aims to provide a better understanding of the mechanisms involved in the development and progression of HBV‐associated hepatocellular carcinoma (HCC) by identifying hub genes and the pathways related to their functions.

Methods

GSE83148 and GSE94660 were selected from the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) with an adjusted p‐value < 0.05 and a |logFC| ≥1 were identified. Common DEGs of two data sets were identified using the GEO2R tool. The Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) databases were used to identify pathways. Protein−protein interactions (PPIs) analysis was performed by using the Cytoscap and Gephi. A Gene Expression Profiling Interactive Analysis (GEPIA) analysis was carried out to confirm the target genes.

Results

One hundred and ninety‐eight common DEGs and 49 hub genes have been identified through the use of GEO and PPI, respectively. The GO and KEGG pathways analysis showed DEGs were enriched in the G1/S transition of cell cycle mitotic, cell cycle, spindle, and extracellular matrix structural constituent. The expression of four genes (TOP2A, CDK1, CCNA2, and CCNB2) with high scores in module 1 were more in tumor samples and have been identified by GEPIA analysis.

Conclusion

In this study, the hub genes and their related pathways involved in the development of HBV‐associated HCC were identified. These genes, as potential diagnostic biomarkers, may provide a potent opportunity to detect HBV‐associated HCC at the earliest stages, resulting in a more effective treatment.
Assessing placental membrane treatment efficiency in diabetic foot ulcers: Processing for retention versus lamination
Authors: Frykberg Robert G. , Tunyiswa Zwelithini
Published: June 2024

Background

Diabetic foot ulcers are a severe complication in diabetic patients, significantly impact healthcare systems and patient quality of life, often leading to hospitalization and amputation. Traditional Standard of Care (SOC) treatments are inadequate for many patients, necessitating advanced wound care products (AWCPs) like human placental membranes. This study conducts a retrospective analysis to compare the effectiveness of two human placental membrane products, retention‐processed amnion chorion (RE‐AC) and lamination‐processed amnion chorion (L‐AC) in managing chronic diabetic foot ulcers (DFUs).

Methods

The study collected retrospective observational data from electronic health records (EHRs) of patients treated for DFU at three outpatient wound care centers. Patients were categorized into two cohorts based on the treatment received. Key metrics included wound size progression and the number of product applications. The analysis employed Bayesian estimation, utilizing an analysis of covariance model with a Hurdle Gamma likelihood.

Results

We found that RE‐AC achieved a marginally higher expected Percent Area Reduction (xPAR) in DFUs compared to L‐AC at 12 weeks (67.3% vs. 52.6%). RE‐AC also required fewer applications, suggesting greater efficiency in general wound closure. Probability of full wound closure was similar in both groups (0.738 vs 0.740 in RE‐AC and L‐AC, respectively).

Conclusion

The findings suggest that while L‐AC might be slightly more effective in complete ulcer healing, RE‐AC offers overall better treatment efficiency, especially in reducing the frequency of applications. This efficiency can lead to improved patient comfort, reduced treatment costs, and optimized resource utilization in healthcare settings.
Bacterial foodborne illness and Escherichia coli O157:H7 strain infection among asymptomatic food handlers in Northeast Ethiopia: Implication for hygienic practices and mass‐screening
Authors: Adefrash Kalu , Sharew Bekele , Amare Wubalem , Shibabaw Agumas
Published: June 2024

Background and Aims

Food‐borne illness is a public health concern in developing countries because of improper food handling and sanitation practices, irregular medical checkups, lack of clean water supplies, and inadequate education among food handlers. This study investigated the burden of bacterial food‐borne illness, antibiotic resistance patterns, and associated factors among food handlers in prison and nonprison food establishment settings.

Methods

A cross‐sectional study was conducted from August 2022 to January 2023 among asymptomatic food handlers in Shewa Robit town. A total of 384 food handlers participated. Data were collected using structured questionnaires. Stool and hand swab samples were collected and cultivated onto MacConkey agar, xylose‐lysine‐deoxycholate, Mannitol salt agar, and blood agar, and incubated at 37°C. Bacterial species were identified using biochemical tests and gram staining. Mueller–Hinton agar was used in Kirby Bauer's disk diffusion method. Data were entered and analyzed using SPSS. Descriptive and logistic regression analysis were performed.

Results

Fecal and hand carriage rate of bacterial isolates were 106 (27.6%), and 214 (55.7%), respectively. Out of the 102 bacterial isolates, the most common ones from stool samples were Escherichia coli 71 (18.5%), Klebsiella aerogenes 12 (3.1%), and Salmonella spp. 7 (1.8%). Among 214 bacterial isolates, coagulase‐negative Staphylococci 115 (29.9%) and Staphylococci aureus 66 (17.3%) were identified from hand swab samples. Hand washing practice after restroom with water (adjusted odds ratio [AOR] = 2; 95% confidence interval [CI]: 1.16–3.45), irregular medical checkups (AOR = 2.49; 95% CI: 1.35–4.59), and did not receive food safety and hygiene training (AOR = 2.33; 95% CI: 1.34–4.05) were statistically significant association with food‐borne illness.

Conclusions

Foodborne pathogens pose a serious health risk in the study areas. The level of antimicrobial resistance are also concerning. Food handlers should therefore get strict regular health education, medical checkups, and training programs to prevent the spread of infections to the customers.
Aloesin ameliorates hypoxic‐ischemic brain damage in neonatal mice by suppressing TLR4‐mediated neuroinflammation
Authors: Chen Liping , Xiong Siqing , Zhou Xiaofan , Fu Qiang
Published: June 2024

Background

At present, neonatal hypoxic‐ischemic encephalopathy (HIE), especially moderate to severe HIE, is a challenging disease for neonatologists to treat, and new alternative/complementary treatments are urgently needed. The neuroinflammatory cascade triggered by hypoxia‐ischemia (HI) insult is one of the core pathological mechanisms of HIE. Early inhibition of neuroinflammation provides long‐term neuroprotection. Plant‐derived monomers have impressive anti‐inflammatory effects. Aloesin (ALO) has been shown to have significant anti‐inflammatory and antioxidant effects in diseases such as ulcerative colitis, but its role in HIE is unclear. To this end, we conducted a series of experiments to explore the potential mechanism of ALO in preventing and treating brain damage caused by HI insult.

Materials and Methods

Hypoxic‐ischemic brain damage (HIBD) was induced in 7‐day‐old Institute of Cancer Research (ICR) mice, which were then treated with 20 mg/kg ALO. The neuroprotective effects of ALO on HIBD and the underlying mechanism were evaluated through neurobehavioral testing, infarct size measurement, apoptosis detection, protein and messenger RNA level determination, immunofluorescence, and molecular docking.

Results

ALO alleviated the long‐term neurobehavioral deficits caused by HI insult; reduced the extent of cerebral infarction; inhibited cell apoptosis; decreased the levels of the inflammatory factors interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐α; activated microglia and astrocytes; and downregulated the protein expression of members in the TLR4 signaling pathway. In addition, molecular docking showed that ALO can bind stably to TLR4.

Conclusion

ALO ameliorated HIBD in neonatal mice by inhibiting the neuroinflammatory response mediated by TLR4 signaling.
Quantitative proteomic analysis of circulating exosomes reveals the mechanism by which Triptolide protects against collagen‐induced arthritis
Authors: Liu Xiuchan , Liu Xu , Wang Hui , Chen Ming , Zhang Geng , Ren Dongyun , Zhang Na , Wei Wei
Published: June 2024

Introduction

Triptolide (TP), a natural product derived from the herbal medicine Tripterygium wilfordii, exhibits potent immunosuppressive activity. However, the mechanisms underlying its effects in rheumatoid arthritis remain incompletely understood.

Methods

Collagen‐induced arthritis (CIA) model was induced in Sprague−Dawley rats by immunization with bovine type II collagen, and TP was administrated as treatment. The therapeutic effect of TP was evaluated based on paw swelling, histopathology, and serum levels of inflammatory factors. Exosomes isolated from rat serum were characterized by transmission electron microscopy, dynamic light scattering, and western blot analysis. Proteomic profiling of exosomes was analyzed by direct DIA quantitative proteomics analysis. Gene ontology and the Kyoto Encyclopedia of Genes and Genomes databases were employed for enrichment analysis related to molecular function, biological processes, and signaling pathways. Western blot analysis was used to analyze differentially expressed proteins.

Results

TP treatment ameliorated arthritic phenotypes in CIA rats as evidenced by reduced arthritis score, paw swelling, pathological injury severity scores, and serum levels of inflammatory cytokines. The proteomic analysis revealed that TP treatment significantly inhibited complement and coagulation cascades, interleukin‐17 signaling pathway, and cholesterol metabolism, which were reactivated in CIA rats. Importantly, lipocalin 2 (LCN2) and myeloperoxidase (MPO) levels were markedly upregulated in the CIA group but suppressed upon TP administration. Furthermore, in synovial tissues, LCN2 and MPO expression levels were also elevated in the CIA group but decreased following TP treatment.

Conclusion

Our findings demonstrate that TP alleviates CIA, possibly through modulation of exosomal LCN2 and MPO proteins.
Stage at diagnosis and survival among adult patients with cancer in Rwanda: A population‐based study
Authors: Hagenimana Marc , Motlhale Melitah , Parkin Donald Maxwell , Businge Lydia , Bardot Aude , Liu Biying , Anastos Kathryn , Castle Philip E. , Murenzi Gad , Claire Kimilu , Sabushimike Daniel , Cyuzuzo Callixte , Kubwiana Gallican , Maniragaba Theoneste , Uwinkindi Francois , Paczkowski Maggie , Soerjomataram Isabelle
Published: June 2024

There are marked disparities in cancer survival in low‐income countries compared to high‐income countries, yet population‐based data in the first is largely lacking. In this study, data from the national cancer registry of Rwanda were examined for 542 patients diagnosed with eight of the most common cancers of adults stomach (C16), colorectum (C18‐20), liver (C22), breast (female) (C50), cervix (C53), ovary (C56), prostate (C61), and non‐Hodgkin lymphomas (C82‐85) between 2014 and 2017. Subjects were randomly selected for active followed‐up to calculate 1‐, 3‐, and 5‐year observed and relative survival (RS) by cancer type and stage. Overall, 53.7% of cases had died within 5 years of diagnosis. Five‐year RS varied by malignancy and ranged from 17.6% (95% confidence interval [CI]: 6.7%–32.6%) for liver cancer to 68% (CI: 51.6%–79.8%) for cancers of the prostate. Stage was assigned for 71.6% of patients (n = 388 of 542), with over half (58%) having advanced stage (III/IV) at diagnosis. For all except liver and ovary, stage was a strong predictor of survival; for example, three‐year observed survival was 90.9% and 44.8% (p‐value: .002) for early and advanced breast cancer, respectively. This study demonstrates that stage specific survival can be obtained from population based cancer registries in sub Saharan Africa, data that are invaluable for international benchmarking, and for local planning and evaluation of cancer control programs.
Similarities in the US Department of Agriculture international baseline projections
Authors: Chandio Rabail , Katchova Ani L.
Published: June 2024

The US Department of Agriculture (USDA) international baseline projections are crucial for US agricultural policy. Using a dynamic time warping algorithm, we examine whether corn, soybean, and wheat baselines exhibit a lack of significant distance indicating similarity in projections across countries. We then examine whether projections for countries with more similarity with the United States projections exhibit higher projection errors. We discover evidence of projections being similar to the United States, which is associated with lower errors for corn yield, harvested area, and exports and wheat import projections, but not for other variables. These findings offer valuable insights for USDA and stakeholders.
Comparison of the impact of longitudinal body mass index changes on cardiac arrest risk between normal and overweight populations
Authors: Kim Youn‐Jung , Kim Min‐Ju , Kim Ye‐Jee , Kim Won Young
Published: June 2024

Background

Being overweight is a key modifiable risk factor for cardiovascular disease. However, the impact of longitudinal changes in body mass index (BMI) on the risk of out‐of‐hospital cardiac arrests (OHCA) remains unclear, especially among overweight populations.

Methods

This nested case–control study utilized data from the Korean National Health Information Database between 2009 and 2018. A total of 23 453 OHCA patients, who underwent national health check‐ups within 1 and 2–4 years before OHCA occurrence, and 31 686 controls, who underwent similar national health check‐ups, were included. The study population was matched for sex, age and survival status. Conditional logistic regression was employed to analyse the odds ratios (ORs) and 95% confidence intervals (CIs) of each BMI per cent change in assessing the risk of OHCA occurrence within 1 year.

Results

A reverse J‐shaped association between BMI per cent change and OHCA risk was observed, even among overweight populations. Among the overweight populations, weight loss significantly increased OHCA risk, with ORs (95% CI) of 4.10 (3.23–5.20) for severe weight loss (BMI decrease > 15%), 2.72 (2.33–3.17) for moderate weight loss (BMI decrease 10–15%) and 1.46 (1.35–1.59) for mild weight loss (BMI decrease 5–10%). Conversely, mild weight gain (BMI increase 5–10%) did not significantly increase OHCA risk. The impact of weight changes on the occurrence of OHCA differed by sex, being more prominent in males.

Conclusions

Significant weight changes within a 4‐year period increase the risk of OHCA with a reverse J‐shaped association, even among overweight and obese individuals. Maintaining a stable weight could be a reliable public health strategy irrespective of the weight status, particularly for males.
Optimizing MMIC performance: The synergy of AI models and heterogeneous integration process
Authors: Liu Jie , Chen Jiayu , Wu Yifan , Su Guodong , Wang Junchao , Xu Yuehang , Liu Jun
Published: June 2024

This study presents a novel approach for optimizing the parameters of monolithic microwave integrated circuit (MMIC) functional units using machine‐learning techniques and multi‐objective optimization algorithms. We utilize advanced machine‐learning methods, including random forest, artificial neural networks (ANNs), and recurrent neural networks (RNNs), to construct highly accurate models that predict the performance of these units. These models are subsequently integrated with a multi‐objective optimization algorithm, specifically the multi‐objective particle swarm optimization (MOPSO), to generate inverse design solutions for both the geometric designs of the units and the fabrication parameters of the heterogeneous integration process. Our approach, which has been validated through chip fabrication and testing, has demonstrated its robustness as a tool for achieving optimal MMIC designs. It not only reduces the design time but also enhances the manufacturability of MMICs, thereby opening new avenues in microwave and RF circuit design.
Sensitivity, linearity, and noise evaluation of L‐shaped dielectrically modulated label free tunnel field‐effect transistor biosensor
Authors: Singh Sruti Suvadarsini , Sahu Prasanna Kumar
Published: June 2024

This research article examines a L‐shaped dielectrically modulated label free TFET (L‐DM‐TFET) biosensor for the purpose of detecting different biomolecules using a label‐free biosensing detection technique. The proposed structure allows for the recognition of biomolecules by modulating various electrical properties, such as the drain current, transconductance, and linearity parameters. The source region of the proposed TFET incorporates a SiGe (source)/Si (channel) heterojunction, utilizing a low bandgap material of SiGe. This heterojunction is employed to enhance the ON‐state current of the devices. The materials used and the fabrication steps involved in our proposed device are compatible with complementary metal‐oxide‐semiconductor (CMOS) technology. This analysis is conducted using a calibrated Silvaco technology computer‐aided design (TCAD) simulator. Additionally, by considering a dielectric constant range of 1–12, we calculate various figure of merits (FOMs) parameters for the device. These include evaluation of linearity, sensitivity, and noise characteristics. Furthermore, we have conducted an analysis of linearity FOMs, such as VIP2, VIP3, IIP3, and IMD3 for the proposed device under study. Additionally, the linearity analysis of the presented tunneling FET (TFET) indicates the device's excellent performance in distortionless switching operations. Consequently, the L‐shaped dielectrically modulated biosensor holds potential suitability for high‐speed circuit designs.
The correlation of long‐range Saharan dust advections with the precipitation and radiative budget in the Central Mediterranean
Authors: Silvestri Lorenzo , Petroselli Chiara , Saraceni Miriam , Crocchianti Stefano , Cappelletti David , Cerlini Paolina Bongioannini
Published: June 2024

This work analyses 10 years (from 2009 to 2018) of long‐range Saharan dust advections (SDAs) and their correlation with the precipitation and radiative budget over the Central Mediterranean region. The identification of the SDAs is based on back‐trajectories (BTs) of air mass and complementary measurements of the dust deposited at the site of Monte Martano in Central Italy. The associated synoptic circulation weather types (CWT), precipitation and radiation variables have been estimated by using ERA5 and CAMS reanalysis, satellite data and raingauge observations. It is found that the 50% of all SDAs occur under a CWT characterized by an upper level trough over the Western Mediterranean and a high‐pressure system over the Eastern Mediterranean. Strong southerly winds, large vertical integral of water vapour transport and a positive anomaly of 2 m temperature are associated with dust uplift and transport. The effect of dust on rainfall intensity puts forward the important modulation of the aerosol effects on the radiative budget with a latitudinal dependence. On dusty days, intense rainfall increases over the northern Central Mediterranean and light rainfall is suppressed in the southern Central Mediterranean, pointing out a relevant correlation between dust and the intensification of extreme events. Other than affecting rainfall intensity, the stronger surface heating over the southern Central Mediterranean, which is correlated to a higher dust optical depth, causes a local maximum of sea surface temperature (SST) and near‐surface temperature anomaly.
How Does Perceived Innovation Importance Underpin the Association Between Deliberate Practice and Employee Creative Behavior
Authors: Yu Shichao , Ayub Arslan , Fatima Tehreem , Hasnain Amna
Published: June 2024

In the pursuit of innovation, the critical role of deliberate practice in enhancing employee creative behavior is examined, considering the influences of harmonious entrepreneurial passion and the importance employees perceive in innovation within their organizations. This investigation, grounded in self‐determination theory (SDT) and social cognitive theory, proposes a model where deliberate practice impacts employee creative behavior through the mediating effect of harmonious entrepreneurial passion and is further amplified by the level of perceived innovation importance. The study uses a multisource, three‐wave data collection technique to gather data from employees working in software houses in Pakistan. The study utilizes SmartPLS (v 4.0) to assess the measurement and structural models. The findings reveal that deliberate practice has a significant positive impact on employee creative behavior. Besides, harmonious entrepreneurial passion mediates the link between deliberate practice and employee creative behavior. In addition, the results confirm the interaction effect of perceived innovation importance. The positive influence of deliberate practice on employee creative behavior through the mediating role of harmonious entrepreneurial passion is more potent at higher levels of perceived innovation importance. The study presents several important theoretical and practical implications.
Predictive Value and Limitations of the Placenta Accreta Index
Authors: Zarudskaya Oxana M. , Boyd Angela R. , Byrne John J. , Berkus Michael D. , Ramsey Patrick S.
Published: June 2024

Our systematic review highlights that multiparametric PAI score assessment is a consistent tool with high sensitivity and specificity for prenatal prediction for placenta accreta spectrum (PAS) in high‐risk population with anterior placenta previa or low‐lying placenta and prior cesarean deliveries. A systematic search was conducted on November 1, 2022, of MEDLINE via PubMed, Scopus, Web of Science Core Collection, Cochrane Library, and Google Scholar to identify relevant studies (PROSPERO ID # CRD42022368211). A total of 11 articles met our inclusion criteria, representing the data of a total of 1,044 cases. Women with PAS had an increased mean PAI total score, compared to those without PAS. Limitations of the PAI are most studies were conducted in developing countries in high‐risk population which limit the global generalizability of findings. Heterogeneity of reported data did not allow to perform meta‐analysis.
New technology and working methods to improve healthcare for suspected malignant skin lesions: Implementation of teledermatoscopy in comprehensive healthcare
Authors: Nemlander E. , Schultz K. , Nilsson G. H. , Lapins J.
Published: June 2024

Background

Suspected malignant skin lesions are common and challenging in terms of diagnostic accuracy and lead time. Efficient use of teledermatoscopy has the potential to improve these factors.

Objectives

This report aims to explore the implementation of teledermatoscopy for quality improvement in a comprehensive healthcare system.

Methods

A stepwise implementation started in 2012 in the Stockholm Region, Sweden, serving 2.4 million inhabitants across approximately 240 primary healthcare centres. The full‐scale implementation occurred from May 2021 to February 2023, utilising a double‐reading teledermatoscopy system. The RE‐AIM framework (reach, effectiveness, adoption, implementation, maintenance) guided the evaluation, including measures such as participant engagement, referrals, diagnoses, staff participation, and centres going on post‐implementation. Descriptive statistics were used.

Results

In the full‐scale implementation period, 10,862 referrals were transmitted, with 17% recommended for biopsy or excision. Among these, 282 (15%) were confirmed melanomas and 516 (28%) non‐melanoma skin cancers. Challenges were observed during the stepwise phase, particularly in engaging primary healthcare and establishing dermatologic consultation capacity. However, all centres and 1263 primary care physicians participated in the fully scaled implementation. Challenges included contractual compliance, adopting a collective system perspective, effective management transition of referrals, cost allocation, and communication improvements. Six months post‐study, most centres used the system, with around 1500 monthly referrals.

Conclusions

The evaluation revealed the overall satisfactory performance of the teledermatoscopy system in terms of reach, effectiveness, adoption, implementation, and maintenance during the fully scaled phase. Results underscore the effectiveness of a stepwise implementation to successfully address contextual challenges. The findings emphasise the system's potential for a broader patient outreach. In conclusion, implementation of teledermatoscopy for quality improvement in a comprehensive healthcare system is an organisational challenge but has the potential to improve healthcare quality for suspected malignant skin lesions.
Experimental Realization of a One‐Directional Broadband Transmissive Cloak in Microwaves
Authors: Li Ruichen , Huang Min , Zou Yijun , Zheng Bin , Luo Caofei , Shen Lian , Jin Hui , Chen Hongsheng
Published: June 2024

Hiding an isolated object in free space using a transmissive invisibility cloak has become a significant research area, propelled by advancements in metamaterials and transformation optics over the past decade. Despite the availability of various simplified methods for implementing transmissive cloaks, issues such as impedance mismatches and narrow working bandwidths often arise, posing challenges. Achieving a broadband transmissive cloak in free space has proven to be particularly arduous. This study presents a near‐perfect one‐directional broadband transmissive cloak constructed from multilayer metasurfaces of arbitrary shapes, showcasing superior performance across a broadband frequency range. The phase distribution of the metasurfaces and the efficacy of the transmissive cloak are assessed using the generalized Snell's law. An experimental near‐perfect broadband transmissive cloak is successfully demonstrated to operate within the frequency range of 8.5 to 11.2 GHz. This study contributes to reducing the density and mass of cloaks, thereby facilitating the expansion of cloaking capabilities in various directions and across different frequency bands.
Crystallographic Engineering to Develop Ultra‐Narrow‐Band Cyan‐Emitting UCr4C4‐Type Phosphor for Healthy LED Lighting and Display
Authors: Wan Yujia , Dang Peipei , Liu Dongjie , Lian Hongzhou , Li Guogang , Lin Jun
Published: June 2024

Narrow‐band cyan‐emitting materials for white light‐emitting diode (wLED) application have shown great potential in increasing the maximum accessible display gamut and improving the color rendering of full‐spectrum healthy lighting. However, the discovery of novel narrow‐band cyan emitters with excellent luminescence performances remains challenging. Here, an ultra‐narrow‐band cyan‐emitting Na5K3(Li3SiO4)8:Eu2+ (N5K3:Eu2+) phosphor (λem = 483 nm) with full width at half maximum (FWHM) of only 18 nm is developed from some typical UCr4C4 frameworks phosphors by slightly modifying crystal structure and symmetry. Through controllable regulation of the ratio of Na and K from Na4K4(Li3SiO4)8:Eu2+ (N4K4:Eu2+) and Na6K2(Li3SiO4)8:Eu2+ (N6K2:Eu2+) to N5K3:Eu2+, the lattice sites forming shoulder peaks are further squeezed to generate the narrowest cyan emission. Moreover, the N5K3:Eu2+ exhibits low photoluminescence thermal quenching (90%@150 °C) and high internal quantum efficiency (IQE) of 50%. The color rendering index of wLED for full‐spectrum health lighting is enhanced from 92 to 94. Using this short‐wavelength cyan emission instead of a part of the emission from a blue chip can effectively prevent “blue hazard”. This work provides basic principles for the design of ultra‐narrow‐band phosphors, thus achieving their applications in the fields of healthy lighting and eye‐friendly display.
Plakophilin 1 in carcinogenesis
Authors: Luo Qiang , Li Xiaojia , Xie Keping
Published: June 2024

Plakophilin 1 (PKP1) belongs to the desmosome family as an anchoring junction protein in cellular junctions. It localizes at the interface of the cell membrane and cytoplasm. Although PKP1 is a non‐transmembrane protein, it may become associated with the cell membrane via transmembrane proteins such as desmocollins and desmogleins. Homozygous deletion of PKP1 results in ectodermal dysplasia‐skin fragility syndrome (EDSF) and complete knockout of PKP1 in mice produces comparable symptoms to EDSF in humans, although mice do not survive more than 24 h. PKP1 is not limited to expression in desmosomal structures, but is rather widely expressed in cytoplasm and nucleus, where it assumes important cellular functions. This review will summarize distinct roles of PKP1 in the cell membrane, cytoplasm, and nucleus with an overview of relevant studies on its function in diverse types of cancer.
Using environmental DNA to elucidate range expansion of bigheaded carp in two Missouri River tributaries in eastern South Dakota
Authors: LaBrie Lindsey A. P. , Wesner Jeff S. , Britten Hugh B.
Published: June 2024

Objective

We used environmental DNA (eDNA) sampling methods to determine the possibility of Bighead Carp Hypophthalmichthys nobilis and Silver Carp H. molitrix (hereafter, bigheaded carp) range expansion above barriers to fish movement in two tributaries of the Missouri River in eastern South Dakota.

Methods

We collected water samples above and below two perceived barriers to fish movement: a natural chain of waterfalls in the Big Sioux River and a spillway at the downstream end of a man-made reservoir in the Vermillion River. We used filtration methods to collect bigheaded carp eDNA from water samples and implemented real-time quantitative polymerase chain reaction techniques to quantify the amount of eDNA in each sample. A total of 198 water samples and 35 field blanks were collected over 2 years (2021 and 2022).

Result

We detected bigheaded carp eDNA below both barriers in 2021 and 2022 and above the barrier in the Vermillion River during 2022. The median posterior prediction value for detecting eDNA below both barriers was 75.3% (95% credible interval [CrI] = 73.2–77.2%) for Bighead Carp eDNA and 54.2% (95% CrI = 51.5–56.4%) for Silver Carp eDNA. The probability of detecting eDNA above the barriers was significantly smaller: 1% (95% CrI = 0.01–1.10%) in the Big Sioux River and 1% (95% CrI = 0.01–1.30%) in the Vermillion River.

Conclusion

The detection of positive samples above the spillway barrier in the Vermillion River provides the first evidence that bigheaded carp may have expanded their range to habitats upstream of their documented range in eastern South Dakota.
Equisetum arvense and nano zinc oxide‐infused polycaprolactone scaffolds: A multifaceted approach for antibacterial, antioxidant, and hemocompatible wound dressing
Authors: Chinijani Turan Hassanzadeh , Afza Saba , Yousefiasl Satar , Manoochehri Hamed , Pourmotabed Samiramis , Arabestani Mohammadreza , Makvandi Pooyan , Sharifi Esmaeel , Esfahani Hamid
Published: June 2024

An appropriate skin tissue‐engineered scaffold can act promptly to combat microbial infection and preserve the wound throughout all phases of healing. To achieve sufficient healing, scaffolds should also promote cell proliferation and regeneration. Therefore, it has become essential to develop skin tissue engineering scaffolds that mimic the extracellular matrices of the skin, provide a high porosity scaffold structure, and act as an antimicrobial protection during wound healing. In this study, the polycaprolactone (PCL) electrospun scaffold was modified with optimal amounts of zinc oxide nanoparticles (ZnO) and Equisetum arvense (EA) herbal extract for potential application as antibacterial and wound healing scaffolds. Full characterization was carried out for fabricated scaffolds before in‐vitro assessments. FTIR spectroscopy and SEM images verified the successful substitution of nanofibers with EA and ZnO. These substitutions increased the hydrophilicity compared to the PCL scaffold. According to the results, the PCL/ZnO/EA fabricated scaffold was hemocompatible and non‐cytotoxic, in addition to allowing proper cell attachment. Effective antibacterial efficiency against Gram‐positive and Gram‐negative bacteria was also observed in this sample. Finally, the in vitro wound healing assay indicated that the addition of ZnO and EA improves the wound healing capacity of the scaffolds. The results indicate the potential of the developed scaffolds to prevent wound contamination and the complications of chronic infection.

Highlights

Optimal concentrations of zinc oxide nanoparticles (ZnO) and Equisetum arvense (EA) were incorporated into electrospun polycaprolactone (PCL) nanofibers for potential wound dressing applications.

The fabricated nanofibrous wound dressings offer a multitude of structural features in biomaterials.

PCL fibers enable the controlled release of both ZnO and EA.

The fabricated scaffolds exhibit favorable antibacterial, and antioxidant properties while maintaining biocompatibility and hemocompatibility.