bluuebunny/crossref_metadata_2025 huggingface dataset:
An Improved Q-Axis Current Control to Mitigate the Low-Frequency Oscillation in a Single-Phase Grid-Connected Converter System
Authors: Wei Kai , Zhao Changjun , Zhou Yi
Published: May 2023

An electric railway system is a typical single-phase grid-connected converter system, and the low-frequency oscillation (LFO) phenomenon in electric railway systems has been widely reported around the world. Previous research has indicated that the LFO is a small-signal instability issue caused by impedance mismatching between the traction network system and electric trains. Therefore, this paper proposes an improved q-axis current control method to reshape the train’s impedance. The proposed method can be implemented easily by relating a reverse q-axis reactive current directly to the reference of the q-axis current under the dq current decoupled control. Moreover, considering the additional q-axis reactive current control, a small-signal impedance model of a train–network system is built. The impedance-based analysis results indicate that the proposed q-axis reactive current feedback control can increase the magnitude of the train’s impedance, which is beneficial to enhancing the system’s stability. Finally, this paper employs experimental results to verify the effectiveness of the proposed method.
Examination of the Hungarian Electricity Industry Structure with Special Regard to Renewables
Authors: Bozsik Norbert , Szeberényi András , Bozsik Nándor
Published: May 2023

The stability of electricity service mainly depends on two main factors. One of them is the country’s power plant capacity and electricity imports. Another factor is the network that delivers electricity to consumers. Recently, consumer electricity production has appeared as a third factor due to the spread of renewable energies. The article focuses on the transformation of the structure of Hungary’s electricity sources between 2010 and 2020. We used the concentration indicator to examine the structure of export–import deliveries with neighboring countries. We also analyzed the centralization of Hungary’s electricity-generating units and the composition of their fuels. In this article, we examined the increasingly widespread renewable energies, which are replacing the traditional—mainly fossil fuel—energy carriers. The relationship between coal, natural gas, nuclear, solar, wind, water, and bioenergy, as well as net imports, were analyzed using a Pearson correlation matrix. This article concludes that renewable energies will cause further transformation in the future, both in the structure of export–import and power plants. In electricity imports, green power is increasingly preferred. Electricity from renewable sources will account for an increasing share of electricity production. In the future, electricity production based on non-renewables will move toward power plants with low carbon dioxide emissions. On the other hand, it is also moving in the direction of fast-reacting power plants due to weather-dependent renewables. Annual system load peaks will continue to increase year after year in the future, thereby posing additional challenges to electricity generation and the electricity grid.
Online Adaptive Parameter Estimation of a Finite Control Set Model Predictive Controlled Hybrid Active Power Filter
Authors: Ferreira Silvia Costa , Foster João Gabriel Luppi , Gonzatti Robson Bauwelz , Pereira Rondineli Rodrigues , Pinheiro Guilherme Gonçalves , Guimarães Bruno P. Braga
Published: May 2023

This paper presents a novel strategy for online parameter estimation in a hybrid active power filter (HAPF). This HAPF makes use of existing capacitor banks which it combines with an active power filter (APF) in order to dynamically compensate reactive power. The equipment is controlled with finite control set model predictive control (FCS-MPC) due to its already well-known fast dynamic response. The HAPF model is similar to a grid-connected LCL-filtered converter, so the direct control of the HAPF current can cause resonances and instabilities. To solve this, indirect control, using the capacitor voltage and the inverter-side current, is applied in the cost function, which creates high dependency between the system parameters and the equipment capability to compensate the load reactive power. This dependency is evaluated by simulations, in which the capacitor bank reactance is shown to be the most sensitive parameter, and, thus, responsible for inaccuracies in the FCS-MPC references. In order to minimize this problem without increasing the complexity of the FCS-MPC algorithm, an estimation technique, based on adaptive notch filters, is proposed. The proposed algorithm is tested in a laboratory prototype to demonstrate its ability to follow variations in the HAPF capacitor reactance, effectively correcting the reactive power reference and providing dynamic reactive power compensation. During the tests, the proposed algorithm was capable of keeping the supplied reactive power within a 1% error, even in a situation with 33% variation in the HAPF capacitor reactance.
The Impact of Export Sophistication of the New Energy Industry on Carbon Emissions: An Empirical Study
Authors: Huang Ke , Wang Teng , Peng Jiachao , Sun Lijun
Published: May 2023

Existing research has insufficiently explored the nexus between the new energy industry and CO2 emissions from the standpoint of export sophistication. This study analyses the implications of the new energy industry’s export sophistication on CO2 emissions, regional heterogeneity, and its influencing mechanism by gathering data from 31 major economies throughout the world between 1996 and 2021. The study found that the new energy industry’s export sophistication helps reduce carbon dioxide emissions, and this conclusion still holds after robustness testing; the carbon emission reduction effect of the export sophistication of the new energy industry is more significant in developed countries than in developing countries; the new energy industry’s export sophistication possesses a crowding-out effect on domestic technological progress, which to a certain extent impedes carbon reduction effect. This paper’s findings provide theoretical guidance for the global low-carbon energy transition.
Performance Investigation of Currently Available Reaction Mechanisms in the Estimation of NO Measurements: A Comparative Study
Authors: Alnasif Ali , Mashruk Syed , Hayashi Masao , Jójka Joanna , Shi Hao , Hayakawa Akihiro , Valera-Medina Agustin
Published: May 2023

Ammonia (NH3) has been receiving the attention of researchers as an alternative promising green fuel to replace fossil sources for energy production. However, the high NOx emissions are one of the drawbacks and restrictions of using NH3 on a broad scale. The current study investigates NO production/consumption for a 70/30 (vol%) NH3/H2 mixture using kinetic reaction mechanism concepts to shed light on the essential reaction routes that promote/inhibit NO formation. Sixty-seven kinetic reaction mechanisms from the literature have been investigated and compared with recently reported measurements at a wide range of equivalence ratios (ϕ) (0.6–1.4), atmospheric pressure and temperature conditions. Both numerical simulations and experimental measurements used the same combustion reactor configuration (premixed stabilized stagnation flame). To highlight the best kinetic model for the predicting of the NO experimental measurements of NO, a symmetric mean absolute percentage error (SMAPE) has been determined as a preliminary estimation by comparing both numerical and experimental measurements. The results found that the kinetic reaction mechanism of Glarborg showed an accurate prediction with a minor error percentage of 2% at all lean and stoichiometric conditions. Meanwhile, the kinetic model of Wang accurately predicted the experimental data with 0% error at ϕ = 1.2 and underestimated the mole fraction of NO at 1.4 ϕ with an error of 10%. The sensitivity analysis and rate of production/consumption of NO mole fractions analysis have also been implemented to highlight the most important reactions that promote/inhibit NO formation. At lean and stoichiometric conditions, Glarborg kinetic model shows that the kinetic reactions of HNO + H ⇌ NO + H2, HNO + O ⇌ NO + OH, and NH + O ⇌ NO + H are the most important reaction routes with considerable effect on NO formation for 70/30 (vol%) NH3/H2 mixture. In contrast, the reactions of NH2 + NO ⇌ N2 + H2O, NH2 + NO ⇌ NNH + OH, NH + NO ⇌ N2O + H, and N + NO ⇌ N2 + O significantly consume NO to N2, NNH, and N2O. Further, Wang’s mechanism illustrated the dominant effect of each HNO + H ⇌ NO + H2, N + OH ⇌ NO + H, NH + O ⇌ NO + H in NO formation and NH + NO ⇌ N2O + H, NH2 + NO ⇌ NNH + OH, and NH2 + NO ⇌ N2 + H2O in the consumption of NO mole fractions.
Dimensioning Air Reactor and Fuel Reactor of a Pressurized CLC Plant to Be Coupled to a Gas Turbine: Part 2, the Fuel Reactor
Authors: Lu Wang , Bartocci Pietro , Abad Alberto , Bischi Aldo , Yang Haiping , Cabello Arturo , de Las Obras Loscertales Margarita , Zampilli Mauro , Fantozzi Francesco
Published: May 2023

Bioenergy with Carbon Capture and Storage (BECCS) technologies are fundamental to reach negative CO2 emissions by removing it from the atmosphere and storing it underground. A promising solution to implement BECCS is pressurized Chemical Looping Combustion (CLC), which involves coupling a pressurized CLC reactor system to a turboexpander. The typical configuration chosen is to have an air reactor and a fuel reactor based on coupled circulating fluidized beds. The fluidization regime in both reactors is preferred to be fast fluidization to enhance gas particle contact and solids circulation among reactors. To design the two reactors, Aspen Plus software was used, given that the new version has a module for fluidized bed modeling. At first, the oxygen carrier was designed ex novo, but given that it is a composite compound mainly made by nickel oxide freeze-granulated on alumina (Ni40Al-FG), the molecular structure has been inserted in Aspen Plus. Then, based on the power of the gas turbine, the power output per kg of evolving fluid (in this case, depleted air) is calculated using Aspen Plus. Once the nitrogen content in the depleted air is known, the total air at the inlet of the air reactor is calculated. The fuel reactor is modeled by inserting the reduction reactions for nickel-based oxygen carriers. The paper presents a useful methodology for developing pressurized Chemical Looping Combustors to be coupled to gas turbines for power generation. The provided data will be cross-validated with 0D-models and experimental results.
IoT-Based Low-Cost Photovoltaic Monitoring for a Greenhouse Farm in an Arid Region
Authors: Hamied Amor , Mellit Adel , Benghanem Mohamed , Boubaker Sahbi
Published: May 2023

In this paper, a low-cost monitoring system for an off-grid photovoltaic (PV) system, installed at an isolated location (Sahara region, south of Algeria), is designed. The PV system is used to supply a small-scale greenhouse farm. A simple and accurate fault diagnosis algorithm was developed and integrated into a low-cost microcontroller for real time validation. The monitoring system, including the fault diagnosis procedure, was evaluated under specific climate conditions. The Internet of Things (IoT) technique is used to remotely monitor the data, such as PV currents, PV voltages, solar irradiance, and cell temperature. A friendly web page was also developed to visualize the data and check the state of the PV system remotely. The users could be notified about the state of the PV system via phone SMS. Results showed that the system performs better under this climate conditions and that it can supply the considered greenhouse farm. It was also shown that the integrated algorithm is able to detect and identify some examined defects with a good accuracy. The total cost of the designed IoT-based monitoring system is around 73 euros and its average energy consumed per day is around 13.5 Wh.
Influence of the Ignition Method on the Characteristics of Propellant Burning in the Context of the Geometric Burning Model
Authors: Leciejewski Zbigniew , Surma Zbigniew , Trębiński Radosław
Published: May 2023

Mathematical models for the simulation of the operation of various projectile-throwing systems are continuously modified, simultaneously with the development of propellants. For these models, properly determined values of energetic ballistic characteristics of propellants are very important. This paper presents an original test and the results of closed vessel comparative investigations. The study analyses specific combustion characteristics of single-base propellants using conventional black powder ignition, plasma ignition, and gas ignition. The results of the study indicate the need to take into account—in the calculation of the burning rate—not only the dynamics of gas pressure changes but also the real (experimental) form function, which differs from the theoretical one resulting from the assumed geometric burning model. The obtained results allow for a critical analysis of the existing methods used for the determination of values of ballistic characteristics of propellants. Further, it will allow for creating pyrostatic test conditions that would reflect the condition of instantaneous ignition of propellant grains over their entire surface in the most realistic way.
Livestock Agriculture Greenhouse Gases for Electricity Production: Recent Developments and Future Perspectives
Authors: Maraveas Chrysanthos , Simeonaki Eleni , Loukatos Dimitrios , Arvanitis Konstantinos G. , Bartzanas Thomas , Kotzabasaki Marianna I.
Published: May 2023

The focus of this review paper was to investigate innovations currently employed to capture and use greenhouse gases produced within livestock farms for energy production and expected future directions. The methods considered for data collection regarded a systematic review of the literature, where 50 journal articles were critically reviewed. The main findings identified that the conventional method used in transforming livestock agriculture greenhouse gases into energy regards the combustion of biogas. However, emerging methods encompass microbial fuel cells, dry biogas reforming, steam biogas reforming, auto thermal Chemical Looping Reforming (CLRa), and gas-to-liquid methods that convert methane to liquid hydrocarbons. The conclusions from the review are that there is a potential to integrate these methods in livestock agriculture in order to generate energy from greenhouse emissions and reduce the reliance on fossil fuels.
Forest by-Product Valorization: Pilot-Scale Pinus radiata and Eucalyptus globulus Bark Mixture Extraction
Authors: Santos Jorge , Escobar-Avello Danilo , Fuentealba Cecilia , Cabrera-Barjas Gustavo , González-Álvarez Julia , Martins Jorge M. , Carvalho Luisa H.
Published: April 2023

One of the most important by-products generated in the forestry industry is the bark obtained during the debarking process. Pine (Pinus radiata D. Don) and eucalyptus (Eucalyptus globulus L.) are the main important tree species exploited in the Chilean forestry industry. The bark of P. radiata D. Don is an interesting source of extracts, rich in condensed tannins, with potential uses in biopolymer and bioadhesive preparation. Conversely, the E. globulus bark extracts are rich in hydrolyzable tannins with few applications. Nevertheless, the forest industry generates a high volume of these by-products, simultaneously. Then, it is interesting to determine a suitable process for the joint valorization of both forest by-products at a large scale. In this work, alkaline extraction (NaOH and Na2SO3) was performed at a pilot scale of a mixture of E. globulus and P. radiata barks prepared at different ratios (0%–100%). The effect of bark mixture composition on the resulting extract’s properties was evaluated. All extracts were characterized according to their chemical composition by FTIR-ATR, MALDI-TOF, and molecular weight distribution (GPC). In addition, the Stiasny number was tested to determine the potential use of extracts in bioadhesive formulation. The self-condensation reaction of resulting extracts was studied using Dynamic Mechanical Analysis (DMA) and Automated Bond Evaluation System (ABES) techniques. Results show a good interaction between condensed and hydrolyzable tannins from both species’ barks. It also demonstrated the potential application of the obtained extracts, for a bark ratio of 50:50, in the formulation of bioadhesives for particleboard manufacture. The obtained product showed a similar performance to that of the bioadhesive formulated with the extract obtained using only P. radiata bark.
Precipitation and Temperature Influence the Relationship between Stand Structural Characteristics and Aboveground Biomass of Forests—A Meta-Analysis
Authors: Ma Yingdong , Eziz Anwar , Halik Ümüt , Abliz Abdulla , Kurban Alishir
Published: April 2023

Forest aboveground biomass (AGB) is not simply affected by a single factor or a few factors, but also by the interaction between them in complex ways across multiple spatial scales. Understanding the joint effect of stand structural characteristics and climate factors on AGB on large scales is critical for accurate forest carbon storage prediction and sustainable management. Despite numerous attempts to clarify the relationships between stand structural characteristics (tree density/TD, diameter at breast height/DBH, basal area/BA), climate factors (mean annual temperature/MAT, mean annual precipitation/MAP), and AGB, they remain contentious on a large scale. Therefore, we explored the relationships between stand structural characteristics, climate factors, and AGB at a biome level by meta-analyzing datasets contained in 40 articles from 25 countries, and then answered the questions of how stand structural characteristics influence AGB at the biome level and whether the relationships are regulated by climate on a large scale. Through using regression analysis and the establishment of a structural equation model, the results showed that the influence of basal area on AGB at the biome level was more substantial than that of tree density and DBH, and the significant relationship between basal area and AGB was relatively stable regardless of biome variation, but the effects of tree density and DBH was non-negligible within the biome. Climatic factors (e.g., temperature and precipitation), should be considered. Our meta-analysis illustrated the complicated interactions between climate factors, stand structural characteristics, and the AGB of forests, highlighting the importance of climate effects on regulating stand structural characteristics and AGB relationships. We suggest that basal area be preferred and considered in forest sustainable management practice to optimize stand structure for increasing carbon storage potential, with close attention to local climate conditions. Overall, our meta-analysis will crucially aid forest management and conservation in the context of global environmental changes, and provide novel insights and a scientific reference to lead to future carbon storage research on large scales.
MOSR and NDHA Genes Comprising G-Quadruplex as Promising Therapeutic Targets against Mycobacterium tuberculosis: Molecular Recognition by Mitoxantrone Suppresses Replication and Gene Regulation
Authors: Dey Arpita , Anand Kushi , Singh Amit , Prasad Ramasare , Barthwal Ritu
Published: April 2023

Occurrence of non-canonical G-quadruplex (G4) DNA structures in the genome have been recognized as key factors in gene regulation and several other cellular processes. The mosR and ndhA genes involved in pathways of oxidation sensing regulation and ATP generation, respectively, make Mycobacterium tuberculosis (Mtb) bacteria responsible for oxidative stress inside host macrophage cells. Circular Dichroism spectra demonstrate stable hybrid G4 DNA conformations of mosR/ndhA DNA sequences. Real-time binding of mitoxantrone to G4 DNA with an affinity constant ~105–107 M−1, leads to hypochromism with a red shift of ~18 nm, followed by hyperchromism in the absorption spectra. The corresponding fluorescence is quenched with a red shift ~15 nm followed by an increase in intensity. A change in conformation of the G4 DNA accompanies the formation of multiple stoichiometric complexes with a dual binding mode. The external binding of mitoxantrone with a partial stacking with G-quartets and/or groove binding induces significant thermal stabilization, ~20–29 °C in ndhA/mosR G4 DNA. The interaction leads to a two/four-fold downregulation of transcriptomes of mosR/ndhA genes apart from the suppression of DNA replication by Taq polymerase enzyme, establishing the role of mitoxantrone in targeting G4 DNA, as an alternate strategy for effective anti-tuberculosis action in view of deadly multi-drug resistant tuberculosis disease causing bacterial strains t that arise from existing therapeutic treatments.
The YBR056W-A and Its Ortholog YDR034W-B of S. cerevisiae Belonging to CYSTM Family Participate in Manganese Stress Overcoming
Authors: Zvonarev Anton , Ledova Larisa , Ryazanova Lubov , Valiakhmetov Airat , Farofonova Vasilina , Kulakovskaya Tatiana
Published: April 2023

The CYSTM (cysteine-rich transmembrane module) protein family comprises small molecular cysteine-rich tail-anchored membrane proteins found in many eukaryotes. The Saccharomyces cerevisiae strains carrying the CYSTM genes YDRO34W-B and YBR056W-A (MNC1) fused with GFP were used to test the expression of these genes under different stresses. The YBR056W-A (MNC1) and YDR034W-B genes are expressed under stress conditions caused by the toxic concentrations of heavy metal ions, such as manganese, cobalt, nickel, zinc, cuprum, and 2.4-dinitrophenol uncoupler. The expression level of YDR034W-B was higher than that of YBR056W-A under alkali and cadmium stresses. The Ydr034w-b-GFP and Ybr056w-a-GFP proteins differ in the cellular localization: Ydr034w-b-GFP was mainly observed in the plasma membrane and vacuolar membrane, while Ybr056w-a-GFP was observed in the cytoplasm, probably in intracellular membranes. The null-mutants in both genes demonstrated decreased cell concentration and lytic phenotype when cultivated in the presence of excess manganese. This allows for speculations about the involvement of Mnc1 and Ydr034w-b proteins in manganese stress overcoming.
An ABCC9 Missense Variant Is Associated with Sudden Cardiac Death and Dilated Cardiomyopathy in Juvenile Dogs
Authors: Furrow Eva , Tate Nicole , Minor Katie , Martinson Shannon , Larrabee Shannon , Anttila Marjukka , Sleeper Meg , Henthorn Paula
Published: April 2023

Sudden cardiac death in the young (SCDY) is a devastating event that often has an underlying genetic basis. Manchester Terrier dogs offer a naturally occurring model of SCDY, with sudden death of puppies as the manifestation of an inherited dilated cardiomyopathy (DCM). We performed a genome-wide association study for SCDY/DCM in Manchester Terrier dogs and identified a susceptibility locus harboring the cardiac ATP-sensitive potassium channel gene ABCC9. Sanger sequencing revealed an ABCC9 p.R1186Q variant present in a homozygous state in all SCDY/DCM-affected dogs (n = 26). None of the controls genotyped (n = 398) were homozygous for the variant, but 69 were heterozygous carriers, consistent with autosomal recessive inheritance with complete penetrance (p = 4 × 10−42 for the association of homozygosity for ABCC9 p.R1186Q with SCDY/DCM). This variant exists at low frequency in human populations (rs776973456) with clinical significance previously deemed uncertain. The results of this study further the evidence that ABCC9 is a susceptibility gene for SCDY/DCM and highlight the potential application of dog models to predict the clinical significance of human variants.
Advancing Erosion Control Analysis: A Comparative Study of Terrestrial Laser Scanning (TLS) and Robotic Total Station Techniques for Sediment Barrier Retention Measurement
Authors: Liu Junshan , Bugg Robert A. , Fisher Cort W.
Published: April 2023

Sediment Barriers (SBs) are crucial for effective erosion control, and understanding their capacities and limitations is essential for environmental protection. This study compares the accuracy and effectiveness of Terrestrial Laser Scanning (TLS) and Robotic Total Station (RTS) techniques for quantifying sediment retention in SBs. To achieve this, erosion tests were conducted in a full-scale testing apparatus with TLS and RTS methods to collect morphological data of sediment retention surfaces before and after each experiment. The acquired datasets were processed and integrated into a Building Information Modeling (BIM) platform to create Digital Elevation Models (DEMs). These were then used to calculate the volume of accumulated sediment upstream of the SB system. The results indicated that TLS and RTS techniques could effectively measure sediment retention in a full-scale testing environment. However, TLS proved to be more accurate, exhibiting a standard deviation of 0.41 ft3 in contrast to 1.94 ft3 for RTS and more efficient, requiring approximately 15% to 50% less time per test than RTS. The main conclusions of this study highlight the benefits of using TLS over RTS for sediment retention measurement and provide valuable insights for improving erosion control strategies and sediment barrier design.
The Pendulum Swings Both Ways: Evidence for U-Shaped Association between Sleep Duration and Mental Health Outcomes
Authors: Kósa Karolina , Vincze Szilvia , Veres-Balajti Ilona , Bába Éva Bácsné
Published: April 2023

Short sleep duration is a known risk to health, but less certain is the impact of longer sleep duration on various measures of health. We investigated the relationship between sleep duration and mental health outcomes in a cross-sectional survey conducted on a homogenous sample of healthy governmental employees (N = 1212). Data on sleep duration, subjective health, psychological stress, sense of coherence, life satisfaction and work ability along with sociodemographic data were collected. Sleep duration was significantly longer, and mental health outcomes and work ability were significantly better among those in at least good subjective health. Fitting mental health outcomes on sleep duration suggested a quadratic or fractional polynomial function, therefore these were tested and the best-fitting models were selected. Longer than 8 h of sleep duration was associated with a decreasing sense of coherence and decreasing work ability. However, psychological stress and life satisfaction were positively impacted by more than 8 h of sleep. Sleep duration likely has an optimum range for health, similar to other variables reflecting homeostatic functions. However, this is difficult to prove due to the left-skewed distribution of sleep duration.
Illness Perceptions of Patients with Occupational Skin Diseases in a Healthcare Centre for Tertiary Prevention: A Cross-Sectional Study
Authors: Rocholl Marc , Wilke Annika , Meyer Julia , John Swen Malte , Ludewig Michaela
Published: April 2023

Objectives: To investigate the illness perceptions of patients with occupational skin diseases (OSDs). Design: Cross-sectional study. Setting: Specialised healthcare centre for inpatient and outpatient individual prevention in occupational dermatology in Germany. Participants: A total of 248 patients with hand eczema (55.2% female; average age: 48.5 years, SD: 11.9) were included in the final analyses. Measures: A modified and recently validated version of the ‘Revised Illness Perception Questionnaire’ (IPQ-R) was used to assess illness perceptions. Severity of skin disease was evaluated with the Patient-Oriented Eczema Measure (POEM), the Osnabrueck Hand Eczema Severity Index (OHSI), and a single, self-reported global item. The Erlangen Atopy Score (EAS) was used for atopy screening. Results: We found strong illness identity, high emotional impact, and long timeline beliefs, meaning that study participants perceive their OSD on the hands as a highly symptomatic, emotionally burdening, and chronic condition. Results suggest that hand eczema has a major impact on how participants manage their own lives, particularly during everyday life and occupational activities. Study participants predominantly identified irritant or sensitising substances and activities at work as well as skin protection regimes as causes of their disease. Conclusions: Healthcare workers should consider the illness perceptions as well as the disease burden of patients with an OSD on the hands in clinical practice. Multi-professional approaches to patient care should be sought. Illness perception in (occupational) dermatological patients should be the subject of further research.
Sulcus Vocalis and Benign Vocal Cord Lesions: Is There Any Relationship?
Authors: Saraniti Carmelo , Patti Gaetano , Verro Barbara
Published: April 2023

Background: Sulcus vocalis (SV) is a longitudinal groove in the free edge of the true vocal cord. It may impair phonation with incomplete glottic closure, phonasthenia and hoarseness. This study aims to detect a correlation between benign vocal cord lesions and the incidence of the SV. Methods: A retrospective study was carried out on patients who underwent transoral surgery due to benign vocal fold lesions and were selected according to strict criteria. Patients were divided into a group with sulcus vocalis (Group wSV) and a group without sulcus vocalis (Group w/oSV). The possible correlations between variables were assessed by the Pearson chi-square test (p < 0.05). Results: The study included 232 vocal cord lesions in 229 patients: 62.88% were females whose mean age was 46.61 ± 14.04. The most frequent diseases were polyps (37.94%), nodules (18.53%) and Reinke’s edema (21.12%). Statistically significant relationships were found between age and SV (p-value 0.0005) and between mild dysplasia and SV (p-value 0.03). Conclusions: This study did not detect a cause–effect relationship between SV and benign vocal fold lesions. SV within vocal fold lesions is more common in younger patients, suggesting a congenital nature of SV. In conclusion, in the case of a benign vocal fold lesion, a possible SV should be considered and researched to provide the patient the best healthcare.
Association between the Expression of Sexual Orientation and/or Gender Identity and Mental Health Perceptions in the Peruvian LGBTI Population
Authors: Castaneda Jane , Poma Nicanor , Mougenot Benoit , Herrera-Añazco Percy
Published: April 2023

Introduction: The non-expression of sexual orientation and gender identity can affect mental health in the lesbian, gay, bisexual, transgender, and intersex population in Peru. Method: Secondary, observational, analytical, and cross-sectional analyses of data from the “First Virtual Survey on the LGBTI population” were conducted with a population (n = 11,345) of LGBTI adults aged 18 years old or more. The variables of mental health and expression of sexual orientation and/or gender identity were measured using a self-reported questionnaire that did not include a validated scale; questions with multiple alternatives that included “yes” and “no” options were used. Prevalence ratios (PR) and 95% confidence intervals (95% CI) were obtained by glm log Poisson regression models. Results: The median age of the participants was 25 years (IQR: 21–30), and the majority of the population identified as gay, followed by lesbian and bisexual. Individuals who expressed their sexual orientation and/or gender identity were 17% less likely to have had perceived mental health problems in the last 12 months (PR: 0.83, 95% CI: 0.76–0.90, p < 0.001). Conclusions: The non-expression of sexual orientation and/or gender identity has a significant negative effect on the mental health problems of the LGBTI population. These results highlight the importance of promoting the expression of sexual orientation and gender identity in our community.
Hikikomori: A Scientometric Review of 20 Years of Research
Authors: Neoh Michelle Jin Yee , Carollo Alessandro , Lim Mengyu , Esposito Gianluca
Published: April 2023

The Japanese term hikikomori was first used to describe prolonged social withdrawal in the 1990s. Since then, research across the world have reported similar prolonged social withdrawal in many countries outside Japan. This study systematically analyses the evolution of literature on hikikomori in the past 20 years to gain a better understanding of the development of the knowledge base on hikikomori since it garnered attention in Japan. Findings from the scientometric review indicate many perspectives on the etiology of hikikomori including cultural, attachment, family systems and sociological approaches. However, similarities with modern type depression, a novel psychiatric syndrome, have been proposed and there are signs of a recent paradigm shift of hikikomori as a society-bound syndrome rather than a cultural-bound syndrome unique to Japan. As research into hikikomori continues to grow, results from the review also highlight the need for a more universally shared definition of hikikomori in order to better consolidate cross-cultural research for meaningful and valid cross-cultural comparisons which can help to promote evidence-based therapeutic interventions for hikikomori.
Evidence of Disaster Planning by Home Care Providers: An Integrative Literature Review
Authors: Lessinnes Sanne , Köhler Michael , Ewers Michael
Published: April 2023

The increasing risk of disasters worldwide poses challenges both to health care infrastructures and to home care providers, who must maintain decentralised services for those in need of long-term care for as long as possible, even under adverse circumstances. However, both the kind of organisational precautions that home care providers consider in preparation for disasters and the available evidence on the effectiveness of these precautions remain largely unclear. An integrative literature review was thus performed via a systematic search of several international databases in order to identify original research on organisational disaster planning by home care providers and to determine the evidence base of this research. The quality of the included studies was assessed using the Mixed Methods Appraisal Tool. Of the 286 results, 12 articles met the inclusion criteria and presented results from nine studies on disaster planning. Three overarching types of activities carried out by home care providers were identified inductively. The overall scientific quality of the studies was moderate, and none investigated the effectiveness of disaster planning by home care providers. Despite the variety of possible activities that home care providers already consider, evidence on how to make organisational disaster planning effective and sustainable remains lacking.
Healthcare Professionals’ Perceptions of and Attitudes towards a Standardized Content Description of Interdisciplinary Rehabilitation Programs for Patients with Chronic Pain—A Qualitative Study
Authors: Åhlfeldt Douglas Anderson , Vixner Linda , Stålnacke Britt-Marie , Boersma Katja , Löfgren Monika , Fischer Marcelo Rivano , Enthoven Paul
Published: April 2023

Interdisciplinary pain rehabilitation (IPR) is a recommended treatment for people with chronic pain. An inadequate description of the content of IPR programs makes it difficult to draw conclusions regarding their effects. The purpose of this study was to describe the perceptions and attitudes of healthcare professionals toward a content description of IPR programs for patients with chronic pain. Individual interviews with healthcare professionals (n = 11) working in IPR teams in Sweden were conducted between February and May 2019. Analysis of the interviews resulted in a theme: interdisciplinary pain rehabilitation is a complex intervention, with three categories: limitations in the description of IPR programs; lack of knowledge about IPR and chronic pain; and facilitating and hindering factors for using the content description of IPR programs. Conclusion: Healthcare professionals perceived that IPR programs could be described through a general content description. A general content description could enhance the quality of IPR programs through a better understanding of their content and a comparison of different IPR programs. Healthcare professionals also expressed the importance of a content description being a guide rather than a steering document.
The Effects of COVID-19 Pandemic on Public Mental Health: State of Art and Future Perspectives
Authors: Sacco Matteo Antonio , Ricci Pietrantonio , Aquila Isabella
Published: April 2023

The COVID-19 pandemic has radically changed our lives in every way [...]
The Effect of Female Directors on ESG Practice: Evidence from China
Authors: Peng Hongyu , Chandarasupsang Tirapot
Published: April 2023

This paper empirically examines the impact of female directors on corporate ESG disclosure scores based on upper echelons theory and women’s ethics of care theory by conducting a multiple regression analysis on 8193 observations of Chinese listed companies from 2010 to 2020. Our results demonstrate the importance of female directors’ participation in promoting corporate ESG practices. We conclude that the higher the proportion of female directors on the board, the higher the corporate ESG practice score. Further analysis also revealed that a favorable institutional environment and non-state enterprises positively moderate the relationship between female directors and corporate ESG practices. These results highlight the significant contribution of female directors to corporate ESG practices. Our paper sheds additional light on issues related to female directors and corporate ESG practices in Chinese listed companies, expands the theoretical knowledge of ethical decision-making and institutional environments in listed companies, enriches research in the area of female directors’ decision-making, and has important implications for corporate governance related policy-making in China.
The Role of Histone Deacetylases in Acute Lung Injury—Friend or Foe
Authors: Luo Guoqing , Liu Bohao , Fu Tinglv , Liu Yi , Li Boyang , Li Ning , Geng Qing
Published: April 2023

Acute lung injury (ALI), caused by intrapulmonary or extrapulmonary factors such as pneumonia, shock, and sepsis, eventually disrupts the alveolar-capillary barrier, resulting in diffuse pulmonary oedema and microatasis, manifested by refractory hypoxemia, and respiratory distress. Not only is ALI highly lethal, but even if a patient survives, there are also multiple sequelae. Currently, there is no better treatment than supportive care, and we urgently need to find new targets to improve ALI. Histone deacetylases (HDACs) are epigenetically important enzymes that, together with histone acetylases (HATs), regulate the acetylation levels of histones and non-histones. While HDAC inhibitors (HDACis) play a therapeutic role in cancer, inflammatory, and neurodegenerative diseases, there is also a large body of evidence suggesting the potential of HDACs as therapeutic targets in ALI. This review explores the unique mechanisms of HDACs in different cell types of ALI, including macrophages, pulmonary vascular endothelial cells (VECs), alveolar epithelial cells (AECs), and neutrophils.
Computational Fluid Dynamics (CFD) Model for Analysing the Role of Shear Stress in Angiogenesis in Rheumatoid Arthritis
Authors: Motlana Malaika K. , Ngoepe Malebogo N.
Published: April 2023

Rheumatoid arthritis (RA) is an autoimmune disease characterised by an attack on healthy cells in the joints. Blood flow and wall shear stress are crucial in angiogenesis, contributing to RA’s pathogenesis. Vascular endothelial growth factor (VEGF) regulates angiogenesis, and shear stress is a surrogate for VEGF in this study. Our objective was to determine how shear stress correlates with the location of new blood vessels and RA progression. To this end, two models were developed using computational fluid dynamics (CFD). The first model added new blood vessels based on shear stress thresholds, while the second model examined the entire blood vessel network. All the geometries were based on a micrograph of RA blood vessels. New blood vessel branches formed in low shear regions (0.840–1.260 Pa). This wall-shear-stress overlap region at the junctions was evident in all the models. The results were verified quantitatively and qualitatively. Our findings point to a relationship between the development of new blood vessels in RA, the magnitude of wall shear stress and the expression of VEGF.
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes
Authors: Gusev Evgenii , Sarapultsev Alexey
Published: April 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to atherogenesis patterns in the context of both canonical and non-classical inflammation types. In this review, we analyze various typical phenomena and outcomes of cellular pro-inflammatory stress in atherosclerosis, as well as the role of endothelial dysfunction in local and systemic manifestations of low-grade inflammation. We also present the features of immune mechanisms in the development of productive inflammation in stable and unstable plaques, along with their similarities and differences compared to canonical inflammation. There are numerous factors that act as inducers of the inflammatory process in atherosclerosis, including vascular endothelium aging, metabolic dysfunctions, autoimmune, and in some cases, infectious damage factors. Life-critical complications of atherosclerosis, such as cardiogenic shock and severe strokes, are associated with the development of acute systemic hyperinflammation. Additionally, critical atherosclerotic ischemia of the lower extremities induces paracoagulation and the development of chronic systemic inflammation. Conversely, sepsis, other critical conditions, and severe systemic chronic diseases contribute to atherogenesis. In summary, atherosclerosis can be characterized as an independent form of inflammation, sharing similarities but also having fundamental differences from low-grade inflammation and various variants of canonical inflammation (classic vasculitis).
Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene
Authors: Kashapov Ruslan , Razuvayeva Yuliya , Kashapova Nadezda , Ziganshina Albina , Salnikov Vadim , Sapunova Anastasiia , Voloshina Alexandra , Zakharova Lucia
Published: April 2023

Supramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for the creation of nanosized particles through the supramolecular self-assembly of RNA with a three-dimensional macrocycle from the calixarene family was reported for the first time. This self-assembly into nanoparticles was realized using cooperative supramolecular interactions under mild conditions. The obtained nanoparticles are able to bind various hydrophobic (quercetin, oleic acid) and hydrophilic (doxorubicin) drugs, as a result of which their cytotoxic properties are enhanced. This work demonstrates that intermolecular interactions between flexible RNA and rigid calixarene is a promising route to bottom-up assembly of novel supramolecular soft matter, expanding the design possibilities of nanoscale drug carriers.
Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models
Authors: Calbiague García Víctor , Cadiz Bárbara , Herrera Pablo , Díaz Alejandra , Schmachtenberg Oliver
Published: April 2023

Diabetic retinopathy causes progressive and irreversible damage to the retina through activation of inflammatory processes, overproduction of oxidative species, and glial reactivity, leading to changes in neuronal function and finally ischemia, edema, and hemorrhages. Current treatments are invasive and mostly applied at advanced stages, stressing the need for alternatives. To this end, we tested two unconventional and potentially complementary non-invasive treatment options: Photobiomodulation, the stimulation with near-infrared light, has shown promising results in ameliorating retinal pathologies and insults in several studies but remains controversial. Boldine, on the other hand, is a potent natural antioxidant and potentially useful to prevent free radical-induced oxidative stress. To establish a baseline, we first evaluated the effects of diabetic conditions on the retina with immunofluorescence, histological, and ultrastructural analysis in two diabetes model systems, obese LepRdb/db mice and organotypic retinal explants, and then tested the potential benefits of photobiomodulation and boldine treatment in vitro on retinal explants subjected to high glucose concentrations, mimicking diabetic conditions. Our results suggest that the principal subcellular structures affected by these conditions were mitochondria in the inner segment of photoreceptors, which displayed morphological changes in both model systems. In retinal explants, lactate metabolism, assayed as an indicator of mitochondrial function, was altered, and decreased photoreceptor viability was observed, presumably as a consequence of increased oxidative-nitrosative stress. The latter was reduced by boldine treatment in vitro, while photobiomodulation improved mitochondrial metabolism but was insufficient to prevent retinal structural damage caused by high glucose. These results warrant further research into alternative and complementary treatment options for diabetic retinopathy.
Fractalkine Improves the Expression of Endometrium Receptivity-Related Genes and Proteins at Desferrioxamine-Induced Iron Deficiency in HEC-1A Cells
Authors: Pandur Edina , Pap Ramóna , Jánosa Gergely , Horváth Adrienn , Sipos Katalin
Published: April 2023

Fractalkine (CX3CL1/FKN) is a unique chemokine belonging to the CX3C chemokine subclass. FKN exists in two forms: a membrane-bound form expressed by both endometrium cells and trophoblasts thought to be implicated in maternal–fetal interaction and a soluble form expressed by endometrium cells. Endometrium receptivity is crucial in embryo implantation and a complex process regulated by large numbers of proteins, e.g., cytokines, progesterone receptor (PR), SOX-17, prostaglandin receptors (PTGER2), and tissue inhibitors of metalloproteinases (TIMPs). It has also been reported that iron is important in fertility and affects the iron status of the mother. Therefore, iron availability in the embryo contributes to fertilization and pregnancy. In this study, we focused on the effect of iron deficiency on the secreted cytokines (IL-6, IL-1β, leukocyte inhibitory factor, TGF-β), chemokines (IL-8, FKN), and other regulatory proteins (bone morphogenic protein 2, activin, follistatin, PR, SOX-17, prostaglandin E2 receptor, TIMP2), and the modifying effect of FKN on the expression of these proteins, which may improve endometrium receptivity. Endometrial iron deficiency was mediated by desferrioxamine (DFO) treatment of HEC-1A cells. FKN was added to the cells 24 h and 48 h after DFO with or without serum for modelling the possible iron dependence of the alterations. Our findings support the hypothesis that FKN ameliorates the effects of anemia on the receptivity-related genes and proteins in HEC-1A cells by increasing the secretion of the receptivity-related cytokines via the fractalkine receptor (CX3CR1). FKN may contribute to cell proliferation and differentiation by regulating activin, follistatin, and BMP2 expressions, and to implantation by altering the protein levels of PR, SOX-17, PTGER2, and TIMP2. FKN mitigates the negative effect of iron deficiency on the receptivity-related genes and proteins of HEC-1A endometrium cells, suggesting its important role in the regulation of endometrium receptivity.