bluuebunny/crossref_metadata_2025 huggingface dataset:
A crinoid fauna and a new species of Pycnocrinus from the Martinsburg Formation (Upper Ordovician), lower Hudson Valley, New York
Authors: Brower James C. , Brett Carlton E. , Feldman Howard R.
Published: May 2024

A new crinoid fauna has been discovered in the Upper Ordovician (Katian) Martinsburg Formation at a small shale quarry, locally known as the ‘Shale Bank,’ on the Shawangunk Ridge in Ulster County, NY. The assemblage, which is from a relatively low energy, offshore mud-bottom environment, includes four identified species, including a new species of glyptocrinid camerate, Pycnocrinus mohonkensis n. sp., described herein. Crinoid taxa in order of increasing branch density in the assemblage include (1) the dicyclic inadunate Merocrinus curtus with irregularly isotomous and heterotomous, non-pinnulate arms and a stout cylindrical column exceeding 700 mm; (2) the disparids Cincinnaticrinus varibrachialus, with heterotomous non pinnulate arms, and Ectenocrinus simplex, with extensively branched ramulate arms and meric columns of 460–500 mm; and (3) the camerate Pycnocrinus mohonkensis n. sp., with uniserial pinnulate arms and a somewhat shorter column. Some cylindrical stems with nodose and holomeric columnals are thought to belong to unknown camerate crinoids with pinnulate arms. Filtration theory is used to model food capture in the Martinsburg crinoids. Surprisingly, even densely pinnulate camerates were able to survive in this setting, suggesting that ambient currents attained velocities exceeding 25 cm/sec even in this offshore setting. Similar assemblages were widespread in eastern Laurentia during the Late Ordovician.

UUID: http://zoobank.org/23ca31e8-f572-4520-ba1d-891e3abb950d
Independence in Europe: Regionalist Party Rhetoric and the EU in a Post-Brexit United Kingdom
Authors: Snowmann Sarah
Published: May 2024

In the wake of Brexit, how has the framing of the EU and independence evolved among regionalist parties in the devolved regions of the UK? The effects of a multilevel structure such as the EU on regionalist parties has been examined, yet European disintegration is novel and thus yet to be fully explored. Has the framing of the EU by these parties shifted, and if so, how? In this article, I analyze 19 regionalist party manifestos between 2011 and 2022 through the lens of rational choice and discursive institutionalism to examine the effects of Brexit on the framing of the EU. At a rhetorical level, these parties have engaged in the subsuming of the EU, rhetorically tying their independence or enhanced autonomy to Brexit. Sinn Féin, Scottish Nationalist Party, and Plaid Cymru have used the critical juncture of Brexit to incorporate the EU into their regionalist rhetoric. By examining the effects of European disintegration on regionalist political parties, we can better understand the role that current events play in the fluidity of party positions as presented in manifestos.
Estimators for Topic-Sampling Designs
Authors: Clifford Scott , Rainey Carlisle
Published: May 2024

When researchers design an experiment, they usually hold potentially relevant features of the experiment constant. We call these details the “topic” of the experiment. For example, researchers studying the impact of party cues on attitudes must inform respondents of the parties’ positions on a particular policy. In doing so, researchers implement just one of many possible designs . Clifford, Leeper, and Rainey (2023. “Generalizing Survey Experiments Using Topic Sampling: An Application to Party Cues.” Forthcoming in Political Behavior. https://doi.org/10.1007/s11109-023-09870-1) argue that researchers should implement many of the possible designs in parallel—what they call “topic sampling”—to generalize to a larger population of topics. We describe two estimators for topic-sampling designs: First, we describe a nonparametric estimator of the typical effect that is unbiased under the assumptions of the design; and second, we describe a hierarchical model that researchers can use to describe the heterogeneity. We suggest describing the heterogeneity across topics in three ways: (1) the standard deviation in treatment effects across topics, (2) the treatment effects for particular topics, and (3) how the treatment effects for particular topics vary with topic-level predictors. We evaluate the performance of the hierarchical model using the Strengthening Democracy Challenge megastudy and show that the hierarchical model works well.
Creating and Using Liturgies for the Commune sanctorum in Medieval Iberia
Authors: Hornby Emma , Jones Marcus , Shaffer Melanie
Published: May 2024

Providing source material for liturgical practice on a significant proportion of feast days in each sanctorale cycle, the Commune sanctorum liturgies had crucial daily importance for medieval Christians. Despite their frequent use, or perhaps because of this prosaic nature, the Commune sanctorum has rarely been considered as a liturgical phenomenon in its own right. Focusing on the Old Hispanic liturgy, this article explores the creation and presentation of the Commune sanctorum. We address systematically a question left unexamined in previous scholarship: where did the Commune sanctorum come from? We first survey the Old Hispanic material shared with other rites. Turning then to the Old Hispanic rite’s unique material, we examine materials found only in the Commons and those shared elsewhere in the rite. We set out a methodology for determining the direction of origin for such shared chants, demonstrating the importance of proper saints’ liturgies in the creation of the Commune sanctorum as well as the creative interest in producing new Commons materials. In addition to the origin of the Commune sanctorum, this article engages with manuscript presentation, asking how Commons materials were organized and how such presentations guided liturgical practitioners. A deeper understanding of the Commune sanctorum opens a window onto one of the foundational devotional experiences of Western Christendom.
Concluding conversation: decentring science diplomacy
Authors: Barrett Gordon , Edington Claire , Homei Aya , de Estrada Kate Sullivan , Wang Zuoyue
Published: May 2024

Gordon Barrett (GB): Research Associate, Centre for the History of Science, Technology and Medicine, University of Manchester, UK (special issue co-editor).
A meta-analysis comparing the efficacy and safety of different modes of administration of cream in the treatment of otomycosis
Authors: Fan Lei , Xu Xue-Meng , Liu Bi-Yao , Huang Jing , Yan Da-Zhong
Published: May 2024

Objective

To assess the efficacy and safety of two different modes of administration, external ear canal filling and smearing, in the treatment of otomycosis.

Methods

A computerised search of relevant published studies in the China National Knowledge Infrastructure, China Biology Medicine, Web of Science, PubMed, Embase and Cochrane Library databases that include randomised controlled trials or clinically controlled trials on the same drug in different modes of administration for the treatment of otomycosis.

Results

Seven studies with 934 patients were included. The filled group had a higher clinical efficacy (relative risk = 1.18, 95 per cent confidence interval (CI) 1.12–1.24, p < 0.0001) and a lower recurrence rate (relative risk = 0.29, 95 per cent CI 0.18–0.47, p < 0.0001) compared with the smear group, and there was no significant difference in the adverse effects (relative risk = 0.61, 95 per cent CI 0.34–1.12, p = 0.11).

Conclusion

Current evidence suggests that the efficacy of the delivery modality of the external auditory canal filling treatment is significantly better than external auditory canal smearing.
Otolith shape can be used as a tool to infer population connectivity among individuals of Larimus breviceps at Southwestern Atlantic
Authors: Carvalho Barbara Maichak de , Barbieri Yasmin , Syrio Beatriz Andrade , Freire Kátia Meirelles Felizola , Tomás Acácio Ribeiro Gomes
Published: May 2024

Otoliths are an excellent tool for analysing the pattern of habitat use between adults and juveniles and connectivity between fish populations. Larimus breviceps is a species belonging to the family Sciaenidae, which has an important role in the marine food chain, as it is one of the most abundant and frequent species in the bycatch of coastal shrimp fisheries in Brazil. The present study aimed at comparing the otolith shape of specimens collected in three different Brazilian coastal areas: Sergipe (SE), northeastern region; São Paulo (SP), southeastern region; and Paraná (PR), southern region. In a laboratory, 88 otoliths were extracted, photographed, and the contour was analysed by the wavelet method (32 from SE, 28 from SP, and 28 from PR). The otolith contours varied between sampling sites. Linear discriminant analysis correctly reclassified 60.23% otoliths by the sampled sites, with the best reclassifications occurring in SE (62.5%), followed by PR (60.71%) and SP (57.14%). Multivariate analysis of variance also evidenced significant differences in contours among the sampling sites (F = 2.3; P < 0.005). Thus, two morphotypes of otoliths were found for L. breviceps: one from Sergipe (northeastern Brazil) and the second one from southeastern–southern Brazil, indicating connectivity between the populations off São Paulo and Paraná, to be confirmed by future genetic studies.
Philometroides giginosantoroi n. sp. (Nematoda: Philometridae), a new muscle-infecting species in the Mediterranean moray (Muraena helena) revealed using integrative taxonomy
Authors: López-Verdejo Alejandro , Occhibove Flavia , degli Uberti Barbara , Crocetta Fabio , Santoro Mario
Published: May 2024

Philometroides Yamaguti, 1935 is a genus of dracunculoid nematodes of the family Philometridae Baylis & Daubney, 1926 comprising tissue-infecting species worldwide. In the present study, a new species of Philometroides is described from the Tyrrhenian Sea (central-western Mediterranean Sea) using integrative approaches such as light and scanning microscopy, histopathology and 18S rRNA sequencing. Philometroides giginosantoroi n. sp. found in the skeletal muscles of the Mediterranean moray Muraena helena can be distinguished from its congeners by a combination of morphological traits and in particular by having the oral aperture with 3 large sclerotized triangular oesophageal teeth. The molecular analyses and phylogenetic reconstructions support its status as a new taxon and placed it within a clade of tissue-infecting species, although also confirmed mismatches in the generic assignment of several species. Philometroides giginosantoroi n. sp. is the second species of the genus found in the Mediterranean Sea and in general in the European marine waters and the third species of the family known to infect the family Muraenidae.
Proxy failures in practice: Examples from the sociology of science
Authors: Kapeller Jakob , Pühringer Stephan , Rath Johanna , Aistleitner Matthias
Published: May 2024

Following John et al., we provide examples of failing proxies that might help to contextualize the role of proxy failures in applied research. We focus on examples from the sociology of science and illustrate how the notion of proxy failure can sharpen applied analysis, if used in a way that does not obscure other dysfunctional effects of proxies.
An updated perspective on teleonomy
Authors: Bartlett Jonathan
Published: May 2024

The analysis of proxy failure given by John et al. provides a good starting point for interdisciplinary discussions. Here, the discussion of teleonomy is extended and updated to include more recent discourse on the topic.
Navigating proxy failures in education: Learning from human and animal play
Authors: Samuelsson Robin
Published: May 2024

The notion of proxy failure provides considerable insight into educational processes, and in childhood education has the potential to elucidate known problems stemming from the early implementation of overly regulated educational regimes. This commentary expands on play and how its relation to learning provides a useful perspective on how activities based on nongoal-oriented interactions can lead to desired outcomes.
English as a global language in China
Authors: Pan Lin , Seargeant Philip
Published: May 2024

While the first decade of the 21st century witnessed an unprecedented level of popularity in English across China, the last ten years have seen a fall in the status of English and a meteoric rise of the importance of the Chinese language and culture in the education system (Feng & Adamson, 2019; Pan & Wang, 2024). The changed status of English was exemplified in the 2017 English curriculum standards (2017 ECS) for senior high school students (aged 16–18). A few years after the implementation of this curriculum, this paper explores how teachers and students perceive the changed status of English as prescribed in the 2017 ECS, and what this means for the role of English as a ‘global language’ in China.
Statistical Insignificance is not wholesale transfer in L3 Acquisition: An approximate replication of Rothman (2011)
Authors: Parrish Kyle
Published: May 2024

This study was an approximate replication of Rothman (2011),examining the determiner phrase syntax of a large sample (n = 211) of L3 learners of Portuguese who spoke English and Spanish. Rothman (2011) investigated whether L3 Italian or Brazilian Portuguese speakers are differently impacted by another known Romance Language, if it was their L1 or L2. The original study concluded that groups did not perform differently on experimental tasks on the basis of a null effect, and that the typological similarity of Spanish, Portuguese, or Italian predicts transfer in the initial stages of L3 acquisition. The present replication recreated all materials, which were unavailable, and examined the same population and questions. However, rather than examining L3 Italian and L3 Brazilian Portuguese, the present work maintained a constant L3 Portuguese. Learners were divided into two groups in a mirror-image design (n = 96 L1 English-L2 Spanish, n = 115 L1 Spanish-L2 English), and data were collected online. Like the original study, there was no main effect of group in any of the two-way analyses of variance. However, results show that it should not be assumed that experimental groups behave equivalently based on a null effect: Of the four total post hoc tests of equivalence, only two were significant when the equivalence bounds were set at a small effect size (d = $ \pm $ .4). Ultimately, it is argued that determining the smallest effect size of interest and subsequent equivalence testing are necessary to answer key questions in the field of L3 acquisition.
Multilingualism in Scientific Literature Communicated by Journals from the SciELO Brazil Collection
Authors: Packer Abel L.
Published: May 2024

This article describes the internationalization of the Scientific Electronic Library Online (SciELO), an open-science programme aimed at the development of capacities and infrastructure in research communication. It manages open-access collections of preprints, articles, research data, books, and book chapters, with a focus on national collections of non-profit peer-reviewed journals published by research communities of academic institutions, scientific societies, and associations. Celebrating 25 years of regular operation, SciELO improves research communication through professionalization, internationalization and sustainability of the indexed journals, maximizing their visibility and impact. In Brazil, the internationalization efforts by SciELO are aligned with national research policies, especially the internationalization of graduate programmes. The SciELO Brazil collection of journals evolves by adopting English solely or with Portuguese to improve the contribution of multilingualism to performing research by subject field. This article covers two decades of scientific literature in SciELO Brazil from 2003 to 2022. During this time, articles written in English or simultaneously in Portuguese and English increased significantly, resulting in a corresponding rise in access and citations received. The progress of the internationalization of the journals in the SciELO Brazil collection through multilingualism has been challenging both operationally and programmatically.
Racial Realities
Authors: Anderson Luvell
Published: May 2024

How should we conceive of conflicts that seem intractable? Is there any hope of a resolution? We observe impasses between various groups concerning the Israeli and Palestinian conflict, the Movement for Black Lives and racial conservatives, and Indigenous voices versus settler colonial states. Some aspects of these impasses can surely be explained by an unwillingness by one or more parties to the conflict to yield any ground. Might there also be room for misunderstanding generated by radically different ways of conceiving the world? According to the different worlds thesis, people come to radically different understandings of the world because they inhabit incompatible conceptual realities. In this article, I endeavor to explore possible ways of understanding the thesis and its potential impact on certain normative practices we tend to take for granted.
Inflammatory Language
Authors: Lepore Ernie
Published: May 2024

This is a paper is about a particular subclass of pejoratives, namely, slurs. These are epithets that denigrate a group on the basis of membership alone, e.g., on the basis of race, ethnicity, origin, religion, gender, or ideology. They carrry a characteristic sting, prone to cause outrage and even injury. As to the source of their characteristic sting, the predominant position invokes some aspect of meaning. Some of the few who reject this assumption locate the source of the sting in the taboo status of pejoratives. Others think slurs can sting because of negative associations they carry across time. We challenge both approaches and defend an alternative, for which negative associations are triggered not by every token of a pejorative, but rather by certain of its articulations.
Exempting Least Developed Countries from Border Carbon Adjustments: Simple Economically but Complex Legally
Authors: Sasmal Sunayana , Zhang Dongzhe , Lydgate Emily , Winters L. Alan
Published: May 2024

The EU has introduced a Carbon Border Adjustment Mechanism (CBAM), which extends its carbon prices to imported products in some sectors. Increasingly considered by other countries, such border carbon adjustments (BCAs) are facing a global backlash against the lack of consideration of the adverse impacts on developing countries and particularly, least developed countries (LDCs). This article first argues that small overall import volumes support the conclusion that exempting or lessening BCA requirements from LDCs would not undermine developed countries' climate-related objectives in practical terms. An economic analysis of EU and UK trade in relation to a CBAM supports this assertion. However, legally, such an exemption or development-based preferential treatment is difficult under existing multilateral trade rules and jurisprudence, owing to the legal characterization and objectives of BCAs; their interaction with existing special and differential treatment (SDT) provisions; and complexity of available policy options. We thus highlight the gap between normative aims of SDT provisions to support development, and current WTO law and jurisprudence which expose WTO members providing preferential treatment to allegations of discrimination. With increasing unilateral climate action, an inability to integrate SDT more meaningfully into WTO non-discrimination frameworks risks further weakening of international cooperation on climate and trade.
Advanced parental cancer and adolescents: Parenting issues and challenges
Authors: Pholsena Thepthara N. , Lewis Frances Marcus , Phillips Farya , Loggers Elizabeth T. , Yockel Mary Rose , Zahlis Ellen H. , Shands Mary Ellen
Published: May 2024

Background

An estimated 609,820 child-rearing adults in 2023 died from advanced cancer, affecting 153,675 dependent children. Although children are known to suffer significant distress when a parent is diagnosed with cancer, few studies have described parents’ views of their adolescent’s behavioral response to their advanced cancer or what the parent did to interpret or manage that response.

Objectives

To describe patient-reported concerns about their adolescent and how they responded to their adolescent’s behavior.

Methods

Single occasion interviews were administered to 6 adolescent-rearing parents with Stage IV cancer. Interviews were analyzed using inductive content analysis by trained coders. Trustworthiness of results was protected through peer debriefing, coding to consensus, and maintaining an audit trail.

Results

The core construct that explained study data was Being There without Taking Over, comprised of 4 domains: Struggling to Read My Child, Attempting to Talk with My Child about My Cancer, Trying to Maintain Optimism, and Understanding My Child.

Conclusions

Parents were deeply concerned about the impact of their advanced cancer on their adolescent but were unable to distinguish between cancer-related distress and adolescent angst. They feared initiating cancer-related discussions and struggled with their own feelings of guilt and parental inadequacy but did not turn to professionals for help.

Significance of results

Adolescent-rearing patients with advanced disease need to be triaged into services that offer a framework from which parents can interpret their child’s behavior and learn ways to have adolescent-appropriate conversations about the cancer. Such services should also help parents gain skills to manage feelings of parental inadequacy and guilt. In the absence of services, parents struggle and do not know how to interpret and respond to their adolescent’s cancer-related behavior.
Lip service to liberal democracy in Western Europe?
Authors: Kaftan Lea
Published: May 2024

Political scientists heavily rely on standard survey questions referring to “democracy” when they study citizens’ attitudes toward (liberal) democracy. However, we only know little about the way in which citizens respond to these questions. This article focuses on two frequently highlighted issues: social desirability and the consistency between citizens’ understanding and researchers’ understanding of the term “democracy.” To address these issues, I collected novel survey data via YouGov from 14,000 British, French, German, and Italian respondents. I use a list experiment to show that respondents do not feel socially pressured to misreport their support for democracy. However, what citizens have in mind when they claim to support democracy only reflects norms and institutions of minimal conceptions of democracy. Overall, this encourages the usage of questions regarding citizens’ support for democracy widely, although this should not be interpreted as the support for anything going beyond minimal conceptions of democracy (providing freedom and allowing for citizens’ influence on political decisions).
Causal Analysis Discovers an Enhanced Impact of Tropical Western Pacific on Indian Summer Monsoon Subseasonal Anomalies
Authors: Du Danni , Subramanian Aneesh C. , Han Weiqing , Ninad Urmi , Runge Jakob
Published: May 2024

Existing studies have shown changes in the impact of atmospheric teleconnections on Indian Summer Monsoon (ISM) at interannual time scales due to the changing background state. However, the exploration of potential changes at subseasonal time scales remains limited. In this study, we use a causal discovery method to find the tropical atmospheric drivers of ISM subseasonal anomalies, and quantify the causal effects of the drivers on ISM, as well as the changes in causal effects over the past 40 years. We find the impact of tropical western Pacific on ISM subseasonal anomalies has strengthened, while the ISM self‐feedback has weakened. Wavenumber‐frequency analysis shows that the Rossby wave energy over 15°N–30°N at periods of 10–20 days has increased over the past four decades, which offers a plausible explanation for the enhanced tropical atmospheric teleconnection between western Pacific and ISM at subseasonal time scales.
Diversity of Stratospheric Error Growth Across Subseasonal Prediction Systems
Authors: Lee R. W. , Charlton‐Perez A. J.
Published: May 2024

The stratosphere has previously been shown to be a significant source of subseasonal tropospheric predictability. The ability of ensemble prediction systems to appropriately exploit this depends on their ability to reproduce the statistical properties of the real atmosphere. In this study, we investigate predictability properties of the coupled stratosphere‐troposphere system in the sub‐seasonal to seasonal prediction project hindcasts by fitting a simple, minimal model. We diagnose the signal and noise components of each system in the stratosphere and troposphere and their coupling. We find that while the correlation skill scores are similar in most systems, the signal to noise properties can be substantially different. In the stratosphere, some systems are significantly overconfident, with a quantifiable impact on the tropospheric confidence. We link the method and details of the design of a prediction system to these predictive properties.
On the Oxygenation Efficacy of Geoengineered Artificial Downwelling in the Estuarine Ecosystem
Authors: Luo Qihao , Xiao Canbo , Lu Wenfang , Lai Zhigang
Published: May 2024

This study examines the oxygenation efficacy of geoengineered artificial downwelling (AD) in the hypoxia zone of the Pearl River Estuary (PRE) using a fine‐resolution coupled physical‐biogeochemical model. Like many estuaries worldwide, the PRE experiences summer hypoxia because of intense stratification and eutrophication. AD provides a potential solution for short‐term hypoxia relief via the mixture of surface and bottom water, but its oxygenation efficacy relying on both local hydrodynamics and biogeochemistry is largely uncertain. Our simulations suggest that AD has extremely low oxygenation efficacy in the PRE during the hypoxia period. The estimated oxygen transfer efficiency (OTE), defined as the rate of oxygen transfer per unit of power needed for pumping, varies between −0.81 and +0.92 kg O2 kWh−1. This is an order of magnitude less than the previous estimate of 10–100 kg kWh−1 in closed lakes and fjords. Moreover, a negative OTE means that AD sometimes backfires and exacerbates hypoxia in the bottom water. The above results remain unchanged when different values of engineering parameters including downwelling rate and discharging depth are used. Extremely low oxygenation efficacy is attributed to strong subtidal advection in the estuary as well as the engineering side effects including reduced vertical diffusion.
Numerical Diffusion and Turbulent Mixing in Convective Self‐Aggregation
Authors: Silvestri L. , Saraceni M. , Bongioannini Cerlini P.
Published: May 2024

Convective Self‐Aggregation (CSA) is a common feature of idealized numerical simulations of the tropical atmosphere in Radiative‐Convective Equilibrium (RCE). However, at coarse grid resolution where deep convection is not fully resolved, the occurrence of this phenomenon is extremely sensitive to subgrid‐scale processes. This study examines the role of mixing and entrainment, provided by the turbulence model and the implicit numerical diffusion. The study compares the results of two models, WRF and SAM, by varying turbulence models, initial conditions, and horizontal spatial resolution. At a coarse grid resolution of 3 km, the removal of turbulent mixing prevents CSA in models with low numerical diffusivity but is preserved in models with high numerical diffusivity. When the horizontal grid resolution is refined to 1 km, CSA can only be achieved by increasing explicit turbulent mixing, even with a small amount of shallow clouds. Therefore, the sensitivity of CSA to horizontal grid resolution is not primarily caused by the decrease in shallow clouds. The analysis of the total water path spectrum suggests that the amplitude of initial humidity perturbations introduced by convection in the free troposphere is the key factor. This amplitude is regulated by turbulent mixing and diffusion at small scales. Prior to the onset of CSA, increased mixing makes updrafts more sensitive to the dryness of the free troposphere, which strengthens the moisture‐convection feedback. This leads to an increased distance between convective cores and a stronger humidity perturbation in the free troposphere, which can destabilize the RCE state.
New Insights Into the Surface‐Ocean Dynamics of the Northeastern Atlantic Ocean Across the Marine Isotope Stage 7
Authors: Singh Harshit , Singh Arun Deo
Published: May 2024

The upper water‐column dynamics and surface productivity variability in the Northeastern Atlantic Ocean across the Marine Isotope Stage (MIS) 7 interglacial complex is not well understood. Here, we present high‐resolution planktic foraminiferal proxies combined with Artificial Neural Network based‐sea‐surface temperature (SST) and ice‐rafted detritus records from International Ocean Discovery Program Site U1385, SW Iberian Margin for the intervals representing MIS 8 deglaciation, MIS 7 interglacial complex and MIS 6 glacial inception. The long‐term SST pattern is modulated by insolation and precession parameters across the MIS 7 interglacial complex and is superimposed by the millennial‐scale variability (stadials at ∼250, ∼243, ∼230, ∼221, ∼203, ∼196 and ∼192 ka). The regional SST records indicate high temperature gradient (∼6°C) between the sub‐polar North Atlantic Ocean and the SW Iberian Margin during MIS 7d which enhanced the moisture transport from mid‐to‐high latitudes. Further, low obliquity with low insolation induced cooling at high latitudes and promoted the expansion of ice‐sheets during MIS 7d. Comparison of our faunal proxies with the published marine and terrestrial records from SW Europe and western Mediterranean Sea suggested a weakening and southward shift of Azores High (AH) pressure system, similar to the present‐day (−) NAO‐like atmospheric configuration during the early phases of MIS 7e, MIS 7c and MIS 7a, resulting reduced surface productivity of SW Iberian Margin. During the late phases of MIS 7e, MIS 7c and MIS 7a, the AH pressure system strengthened and shifted northward causing the intensification of the trade winds, a scenario similar to present‐day (+) NAO‐like atmospheric configuration, which resulted in high surface productivity of SW Iberian Margin.
A Novel Laboratory Technique for Measuring Grain‐Size‐Specific Transport Characteristics of Bed Load Pulses
Authors: Reiterer Kevin , Gold Thomas , Hauer Christoph , Habersack Helmut , Sindelar Christine
Published: May 2024

Although several laboratory studies on the propagation of bed load pulses were carried out in the last decades, most studies neglect grain‐size‐specific aspects or use invasive measurement techniques. To remedy the situation, we present a novel, time‐efficient and non‐destructive laboratory technique to investigate grain‐size‐specific transport characteristics of bed load pulses. The method consists of a through‐water, high‐resolution image acquisition followed by the application of a supervised color classification algorithm (Gaussian Maximum Likelihood Classification). The analyzed bed load pulse consisted of five different grain size classes of dyed quartz sand and gravel, each having a unique color. The initial experimental bed was uni‐colored and contained the same size fractions as the augmented pulse. Quality assessment based on a confusion matrix approach and basic random sampling showed a high classification performance. By statistically analyzing the temporal and spatial color distribution of the experimental reach, characteristic parameters to describe the propagation behavior were determined. The bed load pulse presented in the application example initially showed strong deviations in the grain‐size‐specific advection and dispersion, and advection proved to be predominant in the transport process.
Thank You to Our 2023 Peer Reviewers
Authors: Beal Lisa M. , Chafik Léon , Fawcett Sarah , Flexas Mar , Friedrichs Marjorie A. M. , Gnanaseelan Chellappan , Goodkin Nathalie F. , Lachkar Zouhair , Li Yuanlong , Mulligan Ryan P. , Nagai Takeyoshi , O'Callaghan Joanne (Joe) , Power Hannah E. , von Schuckmann Karina , Sherwood Christopher , Singh Arvind , Umlauf Lars , Vancoppenolle Martin , Wahlin Anna , Xu Fanghua
Published: May 2024

Thank you to the 1396 reviewers who provided 2328 reviews during 2023 to ensure the quality and integrity of JGR‐Oceans manuscripts.
Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals
Authors: Teferi Marta , Gura Hannah , Patel Milan , Casalvera Abigail , Lynch Kevin G. , Makhoul Walid , Deng Zhi-De , Oathes Desmond J. , Sheline Yvette I. , Balderston Nicholas L.
Published: May 2024

Repetitive transcranial magnetic stimulation (rTMS) treatment protocols targeting the right dlPFC have been effective in reducing anxiety symptoms comorbid with depression. However, the mechanism behind these effects is unclear. Further, it is unclear whether these results generalize to non-depressed individuals. We conducted a series of studies aimed at understanding the link between anxiety potentiated startle and the right dlPFC, following a previous study suggesting that continuous theta burst stimulation (cTBS) to the right dlPFC can make people more anxious. Based on these results we hypothesized that intermittent TBS (iTBS), which is thought to have opposing effects on plasticity, may reduce anxiety when targeted at the same right dlPFC region. In this double-blinded, cross-over design, 28 healthy subjects underwent 12 study visits over a 4-week period. During each of their 2 stimulation weeks, they received four 600 pulse iTBS sessions (2/day), with a post-stimulation testing session occurring 24 h following the final iTBS session. One week they received active stimulation, one week they received sham. Stimulation weeks were separated by a 1-week washout period and the order of active/sham delivery was counterbalanced across subjects. During the testing session, we induced anxiety using the threat of unpredictable shock and measured anxiety potentiated startle. Contrary to our initial hypothesis, subjects showed increased startle reactivity following active compared to sham stimulation. These results replicate work from our two previous trials suggesting that TMS to the right dlPFC increases anxiety potentiated startle, independent of both the pattern of stimulation and the timing of the post stimulation measure. Although these results confirm a mechanistic link between right dlPFC excitability and startle, capitalizing upon this link for the benefit of patients will require future exploration.
Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis
Authors: Zhang Qingyu , Chen Caiyun , Zou Xinxin , Wu Weifeng , Di Yunbo , Li Ning , Fu Aizhen
Published: May 2024

Iron is crucial for cell DNA synthesis and repair, but an excess of free iron can lead to oxidative stress and subsequent cell death. Although several studies suggest that cancer cells display characteristics of ‘Iron addiction’, an ongoing debate surrounds the question of whether iron can influence the malignant properties of ovarian cancer. In the current study, we initially found iron levels increase during spheroid formation. Furthermore, iron supplementation can promote cancer cell survival, cancer spheroid growth, and migration; vice versa, iron chelators inhibit this process. Notably, iron reduces the sensitivity of ovarian cancer cells to platinum as well. Mechanistically, iron downregulates DNA homologous recombination (HR) inhibitor polymerase theta (POLQ) and relieves its antagonism against the HR repair enzyme RAD51, thereby promoting DNA damage repair to resist chemotherapy-induced damage. Additionally, iron tightly regulated by ferritin (FTH1/FTL) which is indispensable for iron-triggered DNA repair. Finally, we discovered that iron chelators combined with platinum exhibit a synergistic inhibitory effect on ovarian cancer in vitro and in vivo. Our findings affirm the pro-cancer role of iron in ovarian cancer and reveal that iron advances platinum resistance by promoting DNA damage repair through FTH1/FTL/POLQ/RAD51 pathway. Our findings highlight the significance of iron depletion therapy, revealing a promising avenue for advancing ovarian cancer treatment.
Integrated and DC-powered superconducting microcomb
Authors: Wang Chen-Guang , Xu Wuyue , Li Chong , Shi Lili , Jiang Junliang , Guo Tingting , Yue Wen-Cheng , Li Tianyu , Zhang Ping , Lyu Yang-Yang , Pan Jiazheng , Deng Xiuhao , Dong Ying , Tu Xuecou , Dong Sining , Cao Chunhai , Zhang Labao , Jia Xiaoqing , Sun Guozhu , Kang Lin , Chen Jian , Wang Yong-Lei , Wang Huabing , Wu Peiheng
Published: May 2024

Frequency combs, specialized laser sources emitting multiple equidistant frequency lines, have revolutionized science and technology with unprecedented precision and versatility. Recently, integrated frequency combs are emerging as scalable solutions for on-chip photonics. Here, we demonstrate a fully integrated superconducting microcomb that is easy to manufacture, simple to operate, and consumes ultra-low power. Our turnkey apparatus comprises a basic nonlinear superconducting device, a Josephson junction, directly coupled to a superconducting microstrip resonator. We showcase coherent comb generation through self-started mode-locking. Therefore, comb emission is initiated solely by activating a DC bias source, with power consumption as low as tens of picowatts. The resulting comb spectrum resides in the microwave domain and spans multiple octaves. The linewidths of all comb lines can be narrowed down to 1 Hz through a unique coherent injection-locking technique. Our work represents a critical step towards fully integrated microwave photonics and offers the potential for integrated quantum processors.
The structural basis for 2′−5′/3′−5′-cGAMP synthesis by cGAS
Authors: Wu Shuai , Gabelli Sandra B. , Sohn Jungsan
Published: May 2024

cGAS activates innate immune responses against cytosolic double-stranded DNA. Here, by determining crystal structures of cGAS at various reaction stages, we report a unifying catalytic mechanism. apo-cGAS assumes an array of inactive conformations and binds NTPs nonproductively. Dimerization-coupled double-stranded DNA-binding then affixes the active site into a rigid lock for productive metal•substrate binding. A web-like network of protein•NTP, intra-NTP, and inter-NTP interactions ensures the stepwise synthesis of 2′−5′/3′−5′-linked cGAMP while discriminating against noncognate NTPs and off-pathway intermediates. One divalent metal is sufficient for productive substrate binding, and capturing the second divalent metal is tightly coupled to nucleotide and linkage specificities, a process which manganese is preferred over magnesium by 100-fold. Additionally, we elucidate how mouse cGAS achieves more stringent NTP and linkage specificities than human cGAS. Together, our results reveal that an adaptable, yet precise lock-and-key-like mechanism underpins cGAS catalysis.
Electrochemical-repaired porous graphene membranes for precise ion-ion separation
Authors: Zhou Zongyao , Zhao Kangning , Chi Heng-Yu , Shen Yueqing , Song Shuqing , Hsu Kuang-Jung , Chevalier Mojtaba , Shi Wenxiong , Agrawal Kumar Varoon
Published: May 2024

The preparation of atom-thick porous lattice hosting Å-scale pores is attractive to achieve a large ion-ion selectivity in combination with a large ion flux. Graphene film is an ideal selective layer for this if high-precision pores can be incorporated, however, it is challenging to avoid larger non-selective pores at the tail-end of the pore size distribution which reduces ion-ion selectivity. Herein, we develop a strategy to overcome this challenge using an electrochemical repair strategy that successfully masks larger pores in large-area graphene. 10-nm-thick electropolymerized conjugated microporous polymer (CMP) layer is successfully deposited on graphene, thanks to a strong π-π interaction in these two materials. While the CMP layer itself is not selective, it effectively masks graphene pores, leading to a large Li+/Mg2+ selectivity from zero-dimensional pores reaching 300 with a high Li+ ion permeation rate surpassing the performance of reported materials for ion-ion separation. Overall, this scalable repair strategy enables the fabrication of monolayer graphene membranes with customizable pore sizes, limiting the contribution of nonselective pores, and offering graphene membranes a versatile platform for a broad spectrum of challenging separations.
Tailoring amorphous boron nitride for high-performance two-dimensional electronics
Authors: Chen Cindy Y. , Sun Zheng , Torsi Riccardo , Wang Ke , Kachian Jessica , Liu Bangzhi , Rayner Gilbert B. , Chen Zhihong , Appenzeller Joerg , Lin Yu-Chuan , Robinson Joshua A.
Published: May 2024

Two-dimensional (2D) materials have garnered significant attention in recent years due to their atomically thin structure and unique electronic and optoelectronic properties. To harness their full potential for applications in next-generation electronics and photonics, precise control over the dielectric environment surrounding the 2D material is critical. The lack of nucleation sites on 2D surfaces to form thin, uniform dielectric layers often leads to interfacial defects that degrade the device performance, posing a major roadblock in the realization of 2D-based devices. Here, we demonstrate a wafer-scale, low-temperature process (<250 °C) using atomic layer deposition (ALD) for the synthesis of uniform, conformal amorphous boron nitride (aBN) thin films. ALD deposition temperatures between 125 and 250 °C result in stoichiometric films with high oxidative stability, yielding a dielectric strength of 8.2 MV/cm. Utilizing a seed-free ALD approach, we form uniform aBN dielectric layers on 2D surfaces and fabricate multiple quantum well structures of aBN/MoS2 and aBN-encapsulated double-gated monolayer (ML) MoS2 field-effect transistors to evaluate the impact of aBN dielectric environment on MoS2 optoelectronic and electronic properties. Our work in scalable aBN dielectric integration paves a way towards realizing the theoretical performance of 2D materials for next-generation electronics.
Dynamic Arabidopsis P5CS filament facilitates substrate channelling
Authors: Guo Chen-Jun , Zhang Tianyi , Leng Qingqing , Zhou Xian , Zhong Jiale , Liu Ji-Long
Published: May 2024

In plants, the rapid accumulation of proline is a common response to combat abiotic stress1–7. Delta-1-pyrroline-5-carboxylate synthase (P5CS) is a rate-limiting enzyme in proline synthesis, catalysing the initial two-step conversion from glutamate to proline8. Here we determine the first structure of plant P5CS. Our results show that Arabidopsis thaliana P5CS1 (AtP5CS1) and P5CS2 (AtP5CS2) can form enzymatic filaments in a substrate-sensitive manner. The destruction of AtP5CS filaments by mutagenesis leads to a significant reduction in enzymatic activity. Furthermore, separate activity tests on two domains reveal that filament-based substrate channelling is essential for maintaining the high catalytic efficiency of AtP5CS. Our study demonstrates the unique mechanism for the efficient catalysis of AtP5CS, shedding light on the intricate mechanisms underlying plant proline metabolism and stress response.
Phase segregation and nanoconfined fluid O2 in a lithium-rich oxide cathode
Authors: McColl Kit , Coles Samuel W. , Zarabadi-Poor Pezhman , Morgan Benjamin J. , Islam M. Saiful
Published: May 2024

Lithium-rich oxide cathodes lose energy density during cycling due to atomic disordering and nanoscale structural rearrangements, which are both challenging to characterize. Here we resolve the kinetics and thermodynamics of these processes in an exemplar layered Li-rich (Li1.2–xMn0.8O2) cathode using a combined approach of ab initio molecular dynamics and cluster expansion-based Monte Carlo simulations. We identify a kinetically accessible and thermodynamically favourable mechanism to form O2 molecules in the bulk, involving Mn migration and driven by interlayer oxygen dimerization. At the top of charge, the bulk structure locally phase segregates into MnO2-rich regions and Mn-deficient nanovoids, which contain O2 molecules as a nanoconfined fluid. These nanovoids are connected in a percolating network, potentially allowing long-range oxygen transport and linking bulk O2 formation to surface O2 loss. These insights highlight the importance of developing strategies to kinetically stabilize the bulk structure of Li-rich O-redox cathodes to maintain their high energy densities.
Open e-commerce 1.0, five years of crowdsourced U.S. Amazon purchase histories with user demographics
Authors: Berke Alex , Calacci Dan , Mahari Robert , Yabe Takahiro , Larson Kent , Pentland Sandy
Published: May 2024

This is a first-of-its-kind dataset containing detailed purchase histories from 5027 U.S. Amazon.com consumers, spanning 2018 through 2022, with more than 1.8 million purchases. Consumer spending data are customarily collected through government surveys to produce public datasets and statistics, which serve public agencies and researchers. Companies now collect similar data through consumers’ use of digital platforms at rates superseding data collection by public agencies. We published this dataset in an effort towards democratizing access to rich data sources routinely used by companies. The data were crowdsourced through an online survey and shared with participants’ informed consent. Data columns include order date, product code, title, price, quantity, and shipping address state. Each purchase history is linked to survey data with information about participants’ demographics, lifestyle, and health. We validate the dataset by showing expenditure correlates with public Amazon sales data (Pearson r = 0.978, p < 0.001) and conduct analyses of specific product categories, demonstrating expected seasonal trends and strong relationships to other public datasets.
A quantitative comparison of urine centrifugation and filtration for the isolation and analysis of urinary nucleic acid biomarkers
Authors: Djomnang Liz-Audrey Kounatse , Li Carol , Mzava Omary , Cheng Alexandre Pellan , Chang Adrienne , Lenz Joan Sesing , Suthanthiran Manikkam , Lee John R. , Dadhania Darshana M. , De Vlaminck Iwijn
Published: May 2024

Urine is a rich source of nucleic acid biomarkers including cell-free DNA (cfDNA) and RNA for monitoring the health of kidney allografts. In this study, we aimed to evaluate whether urine filtration can serve as an alternative to the commonly used method of centrifugation to collect urinary fluid and cell pellets for isolating cfDNA and cellular messenger RNA (mRNA). We collected urine specimens from kidney allograft recipients and obtained the urine supernatant and cell pellet from each specimen using both filtration and centrifugation for paired analyses. We performed DNA sequencing to characterize the origin and properties of cfDNA, as well as quantitative PCR of mRNAs extracted from cell fractions. Our results showed that the biophysical properties of cfDNA, the microbial DNA content, and the tissues of origin of cfDNA were comparable between samples processed using filtration and centrifugation method. Similarly, mRNA quality and quantity obtained using both methods met our criteria for downstream application and the Ct values for each mRNA were comparable between the two techniques.The Ct values demonstrated a high degree of correlation. These findings suggest that urine filtration is a viable alternative to urine centrifugation for isolation of nucleic acid biomarkers from urine specimens.