bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanocarrier-based Targeted Delivery in Cancer
Authors: Pancholi Shyam S. , Setia Aseem , Singhai Manu , Chaudhary Atul
Published: December 2022

Anticancer agents are known for their cytotoxic action against tumors, but
the spread of their activity to noncancerous tissue is highly undesirable and may be
toxic. The conventional methods of drug delivery pose numerous restrictions, involving
side effects, lack of patient compliance, etc. Nanocarrier-based drug delivery
alternatives offer the potential for the management of cancer, as they not only confer
better delivery but also efficient targeting to the tissues with limited toxicity.
Nanoparticles offer localization in tumors in the vicinity of capillaries, that accounts for
improved penetration and prolonged detainment of drug in tumors. Under the
tremendous potential of nanoparticles. The exploitation of multi-functional nanocarrier
approaches is a burgeoning research subject, driven by increasing medical needs in the
area of cancer therapy. Several nano-formulation have been approved for the treatment
of cancer. This chapter is an attempt to provide an overview of the recent developments
in nanoparticle formulations for cancer treatment and presents a comprehensive
outlook of the clinical studies and utilization in different prevalent cancers affecting the
brain, lung, breast, colon, cervix, and prostate, etc.
Lipoidal Carrier as Drug Delivery System
Authors: Gidwani Bina , Namdeo Priya , Tiwari Sakshi , Tripathi Atul , Pandey Ravindra Kumar , Shukla Shiv Shankar , Joshi Veenu , Jain Vishal , Thareja Suresh , Vyas Amber
Published: December 2022

The delivery system plays a vital role in managing the pharmacokinetics and
pharmacodynamics of a drug. The size of the carrier system contributes to its
pharmacological action. Lipid-based carriers refer to the formulations containing a
dissolved or suspended drug in lipidic excipients. Lipoidal systems as carriers are
achieving heights due to their significant lipid nature and the size of particles in the
delivery system. The micro/nano-sized lipid-based carriers possess versatility in
improving the physic-chemical properties of drugs. Also, they are biocompatible and
can be administered through all possible routes. Lipid-based drug delivery carrier
systems of new and existing formulations can be commercialized to achieve the desired
range of product specifications. Solubility of the drug in various lipids is a key factor in
the development of the delivery system. Lipids as functional excipients are compatible
with solid, liquid, and semi-solid dosage forms. Besides improving/enhancing the
solubility and bioavailability, lipids provide multiple broad-based applications in the
pharmaceutical delivery system.
Gene Therapy: A New Avenue for the Management of Ophthalmic Diseases
Authors: Karthikeyan Kesavan , Gautam Nivedita , Parra-Marín Olivia , Murugesan Selvasankar
Published: December 2022

Gene therapy aims at intercellular delivery of functional genetic material to
the affected area to restore its function or block a dysfunctional gene using viral vectors
(Adeno-associated virus) or non-viral vectors (liposomes, SLNs). Gene therapy for the
management of ocular diseases is emerging with improved and encouraging results.
The Eye has well-defined anatomy, tight ocular barriers, and immune-privileged. It is a
perfect target for gene therapy. Recently, many clinical trials are underway or have
been completed. The success of these clinical trials promotes the treatment of several
ocular diseases (Age-related macular degeneration, glaucoma, retinitis pigmentosa, and
choroideremia). Gene therapy should possess an efficient targeting capacity and
longstanding gene expression. Viral vectors are mainly used for gene therapy, but due
to the risk associated with immunogenicity and mutagenesis, non-viral vectors are
widely utilized. This chapter summarizes the recent development of therapeutic gene
delivery approaches for the effective management of ocular diseases and their use in
ophthalmology.
Nuevos registros y listados de abejas sin aguijón (Hymenoptera: Apidae: Meliponini) en el corredor biológico Paso del Istmo de Rivas, Nicaragua
Authors: Calero-Pérez Marcos Antonio , Quiroz-Medina Conrado Ronaldo , Joyce Richard , Mérida-Rivas Jorge A. , VANDAME Rémy , Sagot Philippe
Published: December 2022

Las abejas sin aguijón son importantes para los ecosistemas por su papel ecológico como polinizadores. En Nicaragua se sabe poco acerca de su diversidad. En este trabajo, se realizó el primer inventario de abejas sin aguijón en el corredor biológico Paso del Istmo de Rivas, Nicaragua, en los municipios de Cárdenas, San Juan del Sur y Rivas. Se realizaron 31 muestreos dirigidos en plantas en floración en los tres municipios en diferentes agroecosistemas. La colecta se hizo con la técnica de red entomológica principalmente en plantas en floración visitadas por las abejas. Se hizo búsqueda de material bibliográfico que demuestren registros de abejas sin aguijón, actualizando de esta manera las especies reportadas en Nicaragua. En total, se colectaron 109 ejemplares correspondiendo a 11 géneros y 21 especies. Predominan los géneros Plebeia Schwarz, 1938, Scaptotrigona Moure, 1942, Partamona Schwarz, 1939 y Trigona Jurine, 1807. Además, se reportan las especies Nannotrigona perilampoides (Cresson, 1878), Partamona bilineata (Say, 1837), Plebeia moureana Ayala, 1999, Scaura argyrea (Cockerell, 1912), Trigona nigerrima Cresson, 1878, Trigona muzoensis Schwarz, 1948 como nuevos registros para el país, incrementando a 35 especies de abejas sin aguijón registradas en Nicaragua.
Estaciones meteorológicas y estudios dendroclimáticos en México: ¿Cuál estación elegir?
Authors: Gutiérrez Erick , Trejo Irma , Bucio Carolina , Luna Jesús , Miguel Alejandra , Ramírez Minella , Vázquez Mónica
Published: December 2022

Los anillos de crecimiento son un banco de datos que, interpretados a detalle, pueden ayudar a dilucidar eventos climáticos que ocurrieron en el pasado. Para realizar interpretaciones más asertivas es necesario utilizar información proveniente de estaciones meteorológicas cercanas a los sitios de estudio. El objetivo del presente trabajo fue determinar si existen diferencias en condiciones entre las estaciones meteorológicas y los sitios de muestreo que se utilizaron en los estudios dendroclimáticos realizados en México. Se realizó una revisión en diferentes bases de datos científicas y buscadores digitales para obtener todos los trabajos publicados referentes a dendroclimatología cuya zona de estudio fuera en México. Se obtuvieron los valores de las variables propuestas tanto para las estaciones meteorológicas como para los sitios de muestreo de los estudios, para calcular un índice de similitud de condiciones. Se registró un total de 81 estudios, pero solo se analizaron 39 (48%), ya que solo estos expresaban de manera precisa las estaciones utilizadas y las coordenadas geográficas de los sitios de muestreo. Solo 6% de los estudios dendroclimáticos presentaron una alta similitud de condiciones, 41% una similitud media-alta, 46% una similitud media-baja, y 7% una baja similitud de condiciones. Se considera importante realizar, en un futuro cercano, una comparación de condiciones entre las estaciones meteorológicas y los sitios de muestreo en todos los estudios dendrocronológicos; eso se podría realizar con índices de similitud de condiciones como el que se propone en este estudio.
The Challenge of Subtitling Offensive and Taboo Language into Spanish
Authors: Ávila-Cabrera José Javier
Published: December 2022

This book presents a clear and concise guide to understanding the concepts of offensive and taboo language and how this type of language can be subtitled into Spanish for Spain. It includes an array of examples from recent films and TV series as well as exercises which allow the reader to put theory into practice.
Translanguaging, Coloniality and Decolonial Cracks
Authors: Tyler Robyn
Published: December 2022

In this ethnography of bilingual science learning, the author connects microanalyses of classroom discourse to broader themes of de/coloniality in education. The author examines the linguistic landscape of the school and the attitudes of staff and students which produce both coloniality and cracks in the edifice of coloniality.
Reliability and Validity of the Arabic Version of the Game Experience Questionnaire: Pilot Questionnaire Study
Authors: Rebhi Mahmoud , Ben Aissa Mohamed , Tannoubi Amayra , Saidane Mouna , Guelmami Noomen , Puce Luca , Chen Wen , Chalghaf Nasr , Azaiez Fairouz , Zghibi Makrem , Bragazzi Nicola Luigi
Published: December 2022

Background

Nowadays, digital gaming occupies a central position in the entertainment industry where it has developed into a cherished kind of entertainment in markets all over the world. In addition, it provides other sectors with various social and economic benefits. The Game Experience Questionnaire (GEQ) is a free, quantitative, and comprehensive self-report measure that was developed to assess the player game experience. Despite having been widely used by many research projects in the past, it has not been adapted into Arabic. Furthermore, several components of the scale proved problematic from a psychometric point of view. Therefore, a modified version of the scale is needed to measure the gaming experience of the Arab population.

Objective

The aim of this study was to validate and examine the psychometrics of an adapted Arabic version of the GEQ in Tunisia.

Methods

A total of 771 volunteer participants completed an online survey, which included an Arabic version of the GEQ, gaming data, and a sociodemographic questionnaire. Subjects were randomized in order to complete two phases of the study: exploratory and confirmatory. The exploratory data were acquired from 360 respondents whose mean age was 23.89 (SD 2.29) years. Out of 360 respondents, 111 (30.8%) were female and 249 (69.2%) were male. Confirmatory data were obtained from the remaining 411 subjects whose mean age was 21.94 (SD 1.80) years. Out of 411 subjects, 169 (41.1%) were female and 242 (58.9%) were male.

Results

After the elimination of two items, the exploratory and the confirmatory factor analyses provided an adequate factor structure of the Arabic version of the GEQ. In addition, the internal consistency coefficients suggested the reliability of the instrument. Significant differences were revealed for three subcomponents: flow by age (η2=0.013, P=.002), gender (η2=0.007, P=.02), and game type (η2=0.03, P<.001). For competence (η2=0.01, P=.03) and immersion (η2=0.02, P=.01), significant differences were highlighted by the type of game. The discriminant and convergent validities of the instrument were supported by calculating the average variance extracted (AVE) and comparing the square roots of the AVE values to the correlation coefficients, respectively.

Conclusions

The Arabic adapted version of the GEQ is valid and reliable and can be administered to measure the game experience in Arab countries.
Adaptive Content Tuning of Social Network Digital Health Interventions Using Control Systems Engineering for Precision Public Health: Cluster Randomized Controlled Trial (Preprint)
Authors: Rocha Paulo , Pinheiro Diego , de Paula Monteiro Rodrigo , Tubert Ela , Romero Erick , Bastos-Filho Carmelo , Nuno Miriam , Cadeiras Martin
Published: December 2022

BACKGROUND

Social media has emerged as an effective tool to mitigate preventable and costly health issues with social network interventions (SNIs), but a precision public health approach is still lacking to improve health equity and account for population disparities.

OBJECTIVE

This study aimed to (1) develop an SNI framework for precision public health using control systems engineering to improve the delivery of digital educational interventions for health behavior change and (2) validate the SNI framework to increase organ donation awareness in California, taking into account underlying population disparities.

METHODS

This study developed and tested an SNI framework that uses publicly available data at the ZIP Code Tabulation Area (ZCTA) level to uncover demographic environments using clustering analysis, which is then used to guide digital health interventions using the Meta business platform. The SNI delivered 5 tailored organ donation–related educational contents through Facebook to 4 distinct demographic environments uncovered in California with and without an Adaptive Content Tuning (ACT) mechanism, a novel application of the Proportional Integral Derivative (PID) method, in a cluster randomized trial (CRT) over a 3-month period. The daily number of impressions (ie, exposure to educational content) and clicks (ie, engagement) were measured as a surrogate marker of awareness. A stratified analysis per demographic environment was conducted.

RESULTS

Four main clusters with distinctive sociodemographic characteristics were identified for the state of California. The ACT mechanism significantly increased the overall click rate per 1000 impressions (β=.2187; P<.001), with the highest effect on cluster 1 (β=.3683; P<.001) and the lowest effect on cluster 4 (β=.0936; P=.053). Cluster 1 is mainly composed of a population that is more likely to be rural, White, and have a higher rate of Medicare beneficiaries, while cluster 4 is more likely to be urban, Hispanic, and African American, with a high employment rate without high income and a higher proportion of Medicaid beneficiaries.

CONCLUSIONS

The proposed SNI framework, with its ACT mechanism, learns and delivers, in real time, for each distinct subpopulation, the most tailored educational content and establishes a new standard for precision public health to design novel health interventions with the use of social media, automation, and machine learning in a form that is efficient and equitable.

CLINICALTRIAL

ClinicalTrials.gov NTC04850287; https://clinicaltrials.gov/ct2/show/NCT04850287
Secure Comparisons of Single Nucleotide Polymorphisms Using Secure Multiparty Computation: Method Development (Preprint)
Authors: Woods Andrew , Kramer Skyler T , Xu Dong , Jiang Wei
Published: December 2022

BACKGROUND

While genomic variations can provide valuable information for health care and ancestry, the privacy of individual genomic data must be protected. Thus, a secure environment is desirable for a human DNA database such that the total data are queryable but not directly accessible to involved parties (eg, data hosts and hospitals) and that the query results are learned only by the user or authorized party.

OBJECTIVE

In this study, we provide efficient and secure computations on panels of single nucleotide polymorphisms (SNPs) from genomic sequences as computed under the following set operations: union, intersection, set difference, and symmetric difference.

METHODS

Using these operations, we can compute similarity metrics, such as the Jaccard similarity, which could allow querying a DNA database to find the same person and genetic relatives securely. We analyzed various security paradigms and show metrics for the protocols under several security assumptions, such as semihonest, malicious with honest majority, and malicious with a malicious majority.

RESULTS

We show that our methods can be used practically on realistically sized data. Specifically, we can compute the Jaccard similarity of two genomes when considering sets of SNPs, each with 400,000 SNPs, in 2.16 seconds with the assumption of a malicious adversary in an honest majority and 0.36 seconds under a semihonest model.

CONCLUSIONS

Our methods may help adopt trusted environments for hosting individual genomic data with end-to-end data security.
Enhancing Compressive Strength and Dentin Interaction of Mineral Trioxide Aggregate by Adding SrO and Hydroxyapatite
Authors: Yuliatun Leny , Kunarti Eko Sri , Widjijono Widjijono , Nuryono Nuryono
Published: December 2022

In this research, the effect of strontium oxide (SrO) and hydroxyapatite (HA) on the properties of mineral trioxide aggregate (MTA) have been studied. MTA contained 20% SiO2, 60% CaO, and 2% Al2O3. Bi2O3 and SrO have been added with 18% (w/w) total percentage. MTA was prepared with a sol-gel process using a weak base (NH3) as a catalyst and calcined at 1000 °C for 3 h. The effect of HA was investigated by adding various percentages (3, 6, and 9%) on the MTA modified with 5% SrO. The modified MTA (MTA-SrO-HA) products were hydrated using water with the MTA to water weight ratio of 3:1. The results showed that tricalcium silicate (C3S), dicalcium silicate (C2S), Bi2O3, and strontium silicate peaks were detected in the XRD patterns. An increase in the intensity in the infrared spectra of CaO occurred after hybridization with HA. In addition, bonding of Ca-O-Si appeared at 879 and 995 cm−1, indicating the formation of cement. MTA modified with 5% SrO and 6% HA showed similar compressive strength to the commercial MTA (ProRoot brand). Furthermore, MTA-SrO5/HA6 showed a strong interface interaction with dentin adheres without any gaps, indicating a potential dental material for the future.
Simple Green Routes for Metal-Bixin Complexes Synthesis Using Glycerol-Based Deep Eutectic Solvent
Authors: Rahmalia Winda , Shofiyani Anis , Sutiknyawati Yohana , Septiani Septiani
Published: December 2022

Bixin is a natural dye belonging to the carotenoid group that has been reported to have many health benefits. In this work, for the first time, metal-bixin complexes were synthesized through a simple green route using deep eutectic solvent (DES) as reaction media. DES was produced by stirring choline chloride and glycerol with a molar ratio of 1:3. The metal-bixin complex was prepared by grinding and stirring bixin and divalent metal ions (Mg2+, Ca2+, Zn2+, Cu2+, separately) in DES at room temperature. DES formed in this work was a homogeneous colorless liquid with a freezing point below -20 °C. It has a pH, density, viscosity, and conductivity of 7.13, 148.99 cP, 1.207 g/cm3, and 1.8 mS/cm, respectively. UV-Vis spectrophotometric analysis shows that the absorption spectra produced by the Mg(II)-bixin, Ca(II)-bixin, Zn(II)-bixin, and Cu(II)-bixin complexes show an insignificant shift in the direction of a larger wavelength (red shift) compared to pure bixin. Spectral fine structure expressed as %III/II, i.e., the ratio of the height of the longest-wavelength absorption to the middle absorption peak. The value of %III/II for bixin, Mg(II)-bixin, Ca(II)-bixin, Zn(II)-bixin, and Cu(II)-bixin are 16.77, 20.37, 17.39, and 13.52%, respectively. The results of the FTIR spectra analysis confirmed that the bond between bixin and metal ions occurred in the carboxylate acid group, indicated by a decrease in the absorption intensity at wavenumber 3389 and 1716 cm−1.
ULAS: Ketercapaian Pelayanan Publik yang Efektif Berbasis Digital di Kota Surakarta
Authors: Rosidi Valinda Calonica , Sakuntalawati LV Ratna Devi
Published: December 2022

Data Bappenas menunjukan rendahnya skor pelayanan publik pada tubuh pemerintahan. Kondisi ini mengharuskan adanya perbaikan kualitas pelayanan publik. Perbaikan dapat dilakukan salah satunya melalui aspek kemudahan pengaduan masyarakat. Layanan pengaduan masyarakat dinilai signifikan dalam memperbaiki kualitas pelayanan, yang disebabkan dapat secara langsung merespon kebutuhan dan keluhan yang dirasakan oleh masyarakat (bottom up). Merespon urgensi pelayanan pengaduan masyarakat, pemerintah Kota Surakarta saat ini telah mengadopsi Teknologi Informasi dan Komunikasi (TIK) dalam penyelenggaraan kegiatan pemerintahan. Maka dibuatlah inovasi pelayanan pengaduan dengan mengintegrasikan TIK yang dinamakan Unit Layanan Aduan Surakarta (ULAS) sehingga membuka kemudahan akses bagi masyarakat untuk berinteraksi dengan pemerintah secara langsung. Penelitian ini bertujuan untuk mengetahui hubungan antara kesiapan masyarakat menggunakan TIK, partisipasi penggunaan teknologi terhadap ketercapaian pelayanan publik yang efektif. Digunakan Theory Acceptance Model (TAM) dan teori partisipasi untuk mengkaji penelitian ini. Pengaplikasian TAM untuk menganalisis kesiapan memanfaatkan dan penerimaan terhadap teknologi. Sedangkan teori partisipasi menganalisis tingkat keterlibatan pengambilan keputusan yang mempengaruhi kepuasan penggunaan teknologi. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksplanatori dan menggunakan metode survei, yaitu jenis penelitian untuk menguji hubungan antar variabel yang dihipotesiskan dengan cara menyebarkan kuesioner. Hasil yang diperoleh adalah terdapat hubungan tidak murni antara kesiapan masyarakat memanfaatkan TIK dengan ketercapaian pelayanan publik yang efektif yaitu sebesar 0,211 terkategori rendah. Maknanya, harus melalui variabel partisipasi penggunaan teknologi sebagai faktor uji variabel intervening. Akan tetapi, terdapat hubungan bersama-sama antara kesiapan masyarakat memanfaatkan TIK, partisipasi penggunaan teknologi, ketercapaian pelayanan publik yang efektif. Hasil ini sesuai dengan teori TAM milik Fred Davis dan teori partisipasi milik Everett Rogers.
Changes of the temperature field during storms and Effects of Cold Air on Structure of Thermal Fields in Typhoons – Case in China and Vietnam Sea
Authors: Huong Chu Thi Thu , Linh Tran Dinh , Huy Dinh Tran Ngoc , Phong Nguyen Binh
Published: December 2022

This study goal is to explore Changes of the temperature field during storms and Effects of Cold Air on Structure of Thermal Fields in Typhoons. Typhoons are a kind of tropical cyclone that often occur on tropical or subtropical sea surfaces where the sea surface temperature is higher than 26.5 ◦C (HU et al, 2000). The results show that When affected by cold air, the hot core structure in the storm is broken. Temperature tends to increase gradually from west to east and from north to south. Temperatures in the northern and western regions were still lower than in the center of the storm, but in the eastern and southern areas of the center of the storm, the temperature was higher than in the center of the storm. Near the surface, below 800hPa, the temperature of the center of the storm is also lower than the average temperature of the areas around the center of the storm (except for typhoon Kammuri). The decrease in temperature in the lower central region and areas north and west of the center of the storm is due to the intrusion of the CA. This result demonstrates the role of cold air to the structure of the temperature field in the storm. However, further explanations are needed for the distribution of the maximum hot cores in the center of the storm.
Augmented Reality
Authors: Mujumdar Omkar
Published: December 2022

Abstract: Imagine a world with a technology that creates the 3 dimensional images of a virtual object around you with which you can interact, see, hear, smell, and even touch it. Technologies such as computer graphics, virtual reality, and augmented reality together can be used to implement this in real world. Augmented reality actually superimposes virtual objects into the real environment with the real objects for enriching the viewer’s experience Augmented reality with virtual reality in virtual space, also enhances the audience perception by displaying additional information. In this survey we present the different technologies that are involved in the implementation of augmented reality. These technologies are displays which are used for displaying or combining the virtual object by the real environment, tracking or gesture recognition helps in real time interaction part while the modelling is used to register the objects into 3D for enhancing the quality and perception of the viewer.
An Overview of the Emerging Automotive Hybrid Technology
Authors: Luthra Akshat , Tomar Honey , Sharma Nikhil
Published: December 2022

Abstract: Environmental degradation is getting worse as per capita energy use rises. It is crucial to reduce the use of traditional fuel-powered engines while utilising innovative alternative energy sources. Pure electric vehicles cannot be mass produced due to the short timeframe and there are several issues, such as inadequate charging infrastructure. As a result, there is a particular time when the development of hybrid electric vehicles is crucial. This essay introduces the classification of hybrid vehicles, their current state of research, and their likely future development tendencies. It helps the general public understand hybrid electric vehicles, which is important theoretically.
Computer Science and High Dimensional Data Modelling
Authors: Tiwari Adarsh , Kanyal Pradeep , Panchal Himanshu , Bhatia Manjot Kaur
Published: December 2022

Abstract: The need to grasp large database structures is a very important issue in biological and life science. This review paper is aimed toward quantitative medical researchers searching for guidance in modeling large numbers of variables in medical research, how this relates to straightforward linear models and therefore the geometry that underlies their analysis. Issues reviewed include LASSO-related approaches, principal-component based analysis, and problems with model stability and interpretation. Model misspecification issues associated with potential nonlinearities are examined, as is that the Bayesian perspective on these issues.
Why MERN Stack?
Authors: Sharma Harshit , Garg Vaibhav , . Sakshi , Kalra Pankhuri , Bhatia Dr. Manjot Kaur
Published: December 2022

Abstract: In the past, web development was primarily based on the LAMP stack (Linux, Apache, MySQL, PHP, or Perl) and Java-based applications (Java EE, Spring). However, these stacks are made up of different programming languages and can be difficult for a single developer to understand. Advances in web technology over the last few years have allowed developers to participate in both the front-end and back-end processes of web applications. The main goal of this thesis was to explore the basic components of the very popular MREN stack. The MERN stack, which stands for MongoDB, Express.js, React.js, and Node.js, allows developers to easily integrate web development in a single programming language called JavaScript.
Blue Brain Technology
Authors: Wayadande Nikita , Shinde Priya , Kadam Vanmala
Published: December 2022

bstract: “Blue brain” is the name of the world’s first virtual brain. It allows to transfer all the substances of human brain to virtual brain like PC. That means a machine can function as human brain. In other words, human is does not live for thousands of years but the information in his mind could be saved and used for several thousands of years. Today scientists are in research to create an artificial brain that can think, response, take decision, and keep anything in memory. The main aim is to upload human brain into machine. So that man can think, take decision without any effort. After the death of the person the virtual brain can store the knowledge, intelligence, personalities, feelings and memories of that person that can be used for the development of the human society.
Detección de especies maderables mediante sensores químicos de olor, aplicando regularización L1 y modelos de mezclas gaussianas
Authors: Mantilla Ramírez Naren Arley , Porras Gómez Iván Darío , Sepúlveda Sepúlveda Alexander
Published: December 2022

La identificación de las especies maderables ayuda a combatir el tráfico de especies prohibidas. Una forma de realizarla es mediante su olor. En el presente trabajo se muestra un método que tiene por objetivo la detección de especies maderables a partir de trozos previamente cortados y almacenados, mediante la interacción de los compuestos volátiles que estos emanan con una nariz electrónica. El presente dispositivo procesa la respuesta del arreglo de sensores químicos a través de la regularización lineal y modelos probabilísticos con un enfoque similar al usado en sistemas biométricos. En particular, el método presentado incluye una etapa de estimación de parámetros heurísticos sobre las señales entregadas por el arreglo de sensores, seguido de una etapa de selección de variables por medio de regularización L1, para finalmente utilizar modelos de mezclas Gaussianas [GMMs] en el proceso de modelado probabilístico. A modo de resultado, se obtiene un EER promedio de 17.5 % en desempeño en la detección de cuatro especies maderables; y, para el caso particular del Sapán, un EER de 12 % como resultado. En conclusión, este enfoque biométrico da buenos resultados respecto a trabajos anteriores, teniendo en cuenta que en el presente los experimentos se realizan en condiciones más cercanas a la realidad.
Observatorios urbanos y procesos de traducción de conocimiento en el contexto de la investigación y práctica de la planeación
Authors: Anzola Morales John Eduardo
Published: December 2022

Este artículo busca introducir algunos elementos conceptuales que amplíen el conocimiento de los observatorios urbanos y los procesos de traducción de conocimiento que tienen lugar a través de ellos. Para ello, se realizó una revisión bibliográfica que permitió encontrar información sobre los orígenes conceptuales y los primeros modelos de observatorios urbanos, así como sobre su desarrollo y expansión en el marco de las conferencias organizadas por UN-Habitat sobre asentamientos y desarrollo urbano. Asimismo, fue posible identificar elementos sobre la relación de los observatorios con los procesos de producción de conocimiento en las áreas urbanas destinados a mejorar las capacidades de los gobiernos locales, regionales y nacionales en la formulación de políticas públicas y en la toma de decisiones. Adicionalmente, se abordaron algunos de los debates actuales relacionados con la investigación y la práctica en la planificación urbana, especialmente aquellos concernientes a los procesos de traducción del conocimiento, sus interacciones e interfaces. Por último, se presentan algunas conclusiones sobre el papel de los observatorios en la formulación de políticas urbanas y la importancia de profundizar en estos procesos de traducción del conocimiento, pues se trata de un interesante campo de estudio que necesita continuar siendo explorado y profundizado.
Translinguality as an Explication of Appellative Character of Urban Names
Authors: Poplavskaia Tatiana V. , Shylei Alena V.
Published: December 2022

Modern urban names are characterized by properties that allow them to be simultaneously attributed to a special type of mass communication, to episodes of external communication of an organization and acts of self-presentation. A necessary condition for promoting an organization is the formation of trust among the target audience, and strategies for building trust are verbalized through the name to great extend. Within the framework of a single cognitive space, the name of the organization serves as a kind of trigger that includes interest in the organization as a kind of manifestation of feedback: intellectual / mental (I need it), emotional (pleasant place), behavioral (contacting the organization), verbal (discussion).One of the ways to form the attractiveness of names that appeal to the target audience and create a positive image of the organization is to embody the principles of translinguism in urban names. The essence of using the principles of translingualism is the appeal to the entire communicative repertoire of the speaker, as a result of which languages and cultures smoothly flow into each other. When creating the names of urban objects, translatinguality is manifested in the successful use of various language codes. In some cases, the choice of the nominating subject in favor of a particular language in the name of the company is determined by the specifics of the organization’s activities. One of the purposes of using words of foreign origin in the names of organizations is to mimic an imported brand as the level of trust of the target audience in the goods of domestic producers is often lower than in foreign ones. Modern names show more and more varied types of translingual combinations. A common manifestation of translingualism in ergonymy is the contamination of codes, that is, the combination in the name of the organization of units of different languages. Since in a number of cases the intended perception of the meaning of names of this kind is based not only on an adequate understanding of its foreign language component, but also on acquaintance with the realities of another culture that underlie such discursive elements, it is possible to postulate the transcultural nature of a significant part of modern urban names.
Patricia Grace’s “Potiki”: Indigenous Māori Narrative Through the Lens of the Transculturalism Theory
Authors: Galaktionov Semyon S. , Proshina Zoya G.
Published: December 2022

The article examines the identity and work of Patricia Grace, a New Zealand writer of the Māori Renaissance period. Her fate echoes the life stories of many indigenous Māori people with mixed origins, and in regards to that it is interesting to see how this aspect of her existence was reflected in the works she created. Within the framework of this study, Grace’s identity and her literary style are analyzed from the standpoint of theory of translingualism and transculturalism. Particular attention is paid to the criticism and reception of Grace’s work in the literary community and to the development of the most suitable approach to studying her texts. This approach is developed on the basis of the concept of transculturation by F. Ortiz, research by Z.G. Proshina in the field of translingual literature, post-colonial research by H.-K. Trask and the works of M.V. Tlostanova on gender philosophy. Grace’s most famous novel “Potiki” was chosen as an example that confirms the transcultural and translingual nature of her literature. The analysis of the novel allows one to read it as not just a story-driven novel, but as a complex text that contains many elements of Māori culture hidden from a non-indigenous reader.
Time in the Elegiac Poetry of I. Brodsky and R. Kharis: to the Problem of Differences
Authors: Khabibullina Alsu Z.
Published: December 2022

This article is devoted to a comparative study of elegy and elegiac works of I.Brodsky and R.Kharis in the aspect of the category of time as the most important in the architectonics and content of the elegiac genre. The actual basis of the article is formed by such well-known works of Brodsky as “Almost elegy”, “Roman elegies”, “Autumn cry of a hawk” etc. and the elegies of R.Kharis the Tatar poet of the 2nd half of the XX - beginning of the XXI century: “Elegy (There is blue smoke in my room)”, “Seven elegies about the sense of life”, “August”, ‘Cemetery dust”. The conclusion is made about similarity of the type of artistic thinking of the two authors, which is based on the dominance of the rational beginning in creativity. It is stated that lyrical hero of Kharis’s elegies is not opposed to time, his century unlike the hero of the elegies of Brodsky, who chooses the point of “non-occurrence” in relation to time; time in his poetry is taken beyond the limits of being. If the value for the elegiac hero of the Tatar author becomes the natural connection of phenomena and things with each other, as well as the interaction of life and death, then Brodsky emphasizes the fragmentation and fragility of the world as a property of its metaphysical perception (“Almost elegy”, “Roman elegies”). The comparative analysis also revealed different forms of transformation of the elegy and the elegiac mode of artistry in multilingual works. Thus, in the “Seven elegies…” by Kharis the final part of the cycle differs from the state of “mixed feelings” necessary for the poetics of the genre. On the contrary, in the elegy, the idea of human loneliness is strengthened: expansion into the world of heaven turns it into a stable state of cosmic being.
From Intercultural Communication to Transcultural Creativity: A Study of Russian-American Fiction
Authors: Lebedeva Ekaterina S.
Published: December 2022

The world has been growing more globalised, people have been moving and absorbing different cultural peculiarities. Now intercultural perspective might seem insufficient to describe the extent to which local cultures and identities are linked globally. As a result, language contact and communication between and across cultures have been changing. The present paper aims at studying modern RussianAmerican fiction from intercultural and transcultural perspectives emphasizing the translingual features and transcultural changes. The paper discusses the phenomenon of creative translingualism, which means writing in one or two languages that are not the native tongues. Contemporary American literature may be proud of its modern writers of Russian and Soviet descent: Olga Grushin, Sana Krasikov, Lara Vapnyar, Anya Ulinich, Irina Reyn. All the authors changed their country of birth and moved to the USA and as a result, they chose English as the language of their creative writings. However, the English of their works reflects the Russian language, culture, and identity of the writers making the English text not truly English. The research primarily studies the linguistic tools (borrowing, code mixing, code-switching and broken English) used by the writers to render Russian culture by means of the English language as well as the transcultural shift that has been inevitable and has become an inalienable part of new cultural identities.
Native reed-specific bird Reed Parrotbill appears in exotic Smooth Cordgrass
Authors: Wu Dawei , Chen Pan , Wang Zhenqi , Lu Changhu
Published: December 2022

Bird diversity has declined as native birds have avoided using the green
desert after the smooth cordgrass Spartina alterniflora invaded coastal
China. After many years of coexistence, a few passerine birds began to
enter and use Smooth Cordgrass to breed, but only birds of
nonspecialised habitat. In this study, we first found that a native
reed-specific bird, the Parrotbill Calamornis heudei, flocked and sang
in a Smooth Cordgrass habitat near Sheyang Port in Yancheng, Jiangsu
Province. This phenomenon indicates that native obligate birds may be
forced to adapt to exotic Smooth Cordgrass habitats after long-term
coexistence; obviously, the distribution, feeding and reproduction of
birds would be affected, which may lead to unknown ecological
consequences. We suggest that more research attention should be given to
this process occurring along the Chinese coast.
Congenital urticaria pigmentosa mistaken for non-accidental injury
Authors: Porter Emma , Heffron Cynthia , Murphy Lesley-Ann , O'Connor Cathal
Published: December 2022

Awareness of cutaneous manifestations of non-accidental injury (NAI) is
essential for healthcare professionals working with children. Some
cutaneous conditions may present with bruise-like lesions that can mimic
NAI. We present the case of a male infant referred for investigation of
NAI, who was subsequently diagnosed with cutaneous mastocytosis.
New Conceptual Rainfall-Runoff Model: Alternate Infiltration and Saturation Excess
Authors: Berehanu Belete
Published: December 2022

Observing flows on land surfaces, streams, and rivers is complex,
expensive, and time-consuming. Simultaneously, accurate runoff and
stream flow data are scarce. Therefore, a simple rainfall-runoff model
that mimics the real-world system becomes indispensable. Although wide
ranges of rainfall-runoff methods/models have been developed in the
past, most have inherent limitations in simulating different
hydrological systems. With a thorough evaluation and review of
rainfall-runoff methods, a new conceptual model that can simulate
alternative runoff generation, infiltration, and saturation excess, has
developed. The new model quantifies the stream flow with a multi-layered
approach and well separates the contributions of infiltration-excess
runoff (IRun), saturation excess runoff (SRun), sub-soil lateral flow or
interflow (IFlow), and the base flow (BFlow). The model’s performance
has also been proved using the calibration and validation processes of
six randomly selected gauged catchments from different river basins in
Ethiopia as representative of tropical-monsoon hydrological systems. The
ranges of statistical values for R-square, RMSE, NSE, and PBIAS were
0.77- 0.87, 0.47 -1.04, 0.52- 0.93, and 0.0, respectively, confirming
that the new model performs well for different hydrological systems.
Moreover, the single-user-interface computer programs for the model
running also facilitate its use as plugging with various tools,
including GIS packages and database catalog systems.
Effects of a new mixed laser wavelength 10600 + 1540 nm on the genitourinary syndrome in postmenopausal women: a single-blind randomized parallel controlled trial
Authors: PEÑA JUAN SALINAS , Tameish Sara , Curulla Rosa Pedró , Calzada Carmen Guilarte , Alberich Rosa Solà , Busquets Pere Cavallé
Published: December 2022

Objectives. To evaluate the efficacy and safety of a mixed wavelength
laser 10600 and 1540 nm using low-power 5 W CO2, on the vaginal
maturation value (VMV) and genitourinary syndrome of menopause (GSM).
Design. randomized single-blind sham-controlled trial. Setting. Hospital
Universitari Sant Joan de Reus, Spain. Population. 31 postmenopausal
women with GSM symptoms and VMV <50%. Methods. Patients were
randomized to laser or sham intervention, consisting of monthly laser or
sham treatments for three consecutive months. Evaluations were at
baseline, 3- and 9-months post-intervention. Main outcome measures. The
primary outcome was the effect on VMV; secondary outcomes were vaginal
pH, and visual analogue scale (VAS) for GSM symptoms at 3 and 9 months.
Also, adverse events were evaluated. Results: 27 patients completed the
study, 14 were randomly assigned to the laser arm and 13 to the sham
arm. At 3 months, VMV increased significantly in the laser group (44.5%
± 4.4) compared to sham group (27.7% ± 6.3) (P = 0.033), at 9 months,
VMV in the laser group was similar to baseline values and VAS scores for
GSM decreased for dyspareunia in the laser group compared to the sham
group (P = 0.049). Vaginal pH remained unchanged. Treatment was well
tolerated with adverse effects equivalent to the sham group.
Conclusions: At the first 3 months, mixed laser wavelengths 10600 + 1540
nm increased VMV and at 9 months, dyspareunia was reduced. Laser
treatment was safe and well tolerated with adverse effects similar to
the sham group. ClinicalTrialRegistry NCT039565
Violation detection based on a modified transformer encoder network with Bi-LSTM
Authors: Zeng Yuyu , Zhang Yu , Zhu XinSheng , Gao Lan
Published: December 2022

Due to the rapid growth of China’s security market, the early detection
of accounting violations by listed companies has become increasingly
urgent. However, the current lack of regulatory efficiency means that
such problems are often not detected and solved. To solve these issues,
researchers have proposed traditional methods and artificial
intelligence methods in recent decades. However, some existing methods
have high requirements for setting indicators and parameters, and their
detection accuracy could be improved. To take advantage of the concept
of the self-attention mechanism, we built a modified transformer encoder
network with Bi-LSTM to analyze accounting data and identify whether
there are violations by listed companies. This model attempts to enhance
the long-term feature capture capability for processing structural data,
such as accounting data, through Bi-LSTM and stacking multiple
transformer encoder networks while reducing the speed of computation due
to the parallel power of the self-attention mechanism. Several
experiments were conducted on the accounting dataset released by the
open-source China Stock Market & Accounting Research (CSMAR). The
results show that the proposed model, by the composition of Bi-LSTM as
the input layer and three layers of transformer encoder network, has the
best detection performance in comparison to the deep neural network
(DNN), random forest models, etc., with a testing accuracy of 0.9758 and
an AUC of 0.98. Furthermore, we embedded the pretrained model in a
WeChat miniprogram to provide a better interactive experience for users
during the preliminary detection of a single file with the required
accounting data.
Copula-based joint distribution analysis of wind speed and wind direction: wind energy development for Hong Kong
Authors: Li Qiu , Huang Shiji , Shu Zhenru , Chan P.W.
Published: December 2022

Accurate assessment of wind energy potential can provide important
implication regarding the optimalization of micro-siting of wind
turbines and increase of wind power generation. It is, however,
noteworthy that most previous studies on wind energy resource assessment
focused solely on wind speed, whereas the dependence of wind energy on
wind direction was much less considered and documented. In the current
study, a copula-based method is proposed to better characterize the
direction-related wind energy potential at six typical sites in Hong
Kong. In the first step, several widely used statistical models are
adopted to fit the marginal distributions of wind speed and direction.
The joint probability density function (JPDF) of wind speed and wind
direction is therewith constructed by various copula models. The
goodness-of-fit evaluation indicates that Frank copula has the best
performance to fit the JPDF at hilltop and offshore sites, while Gumbel
copula outperforms other models at downtown sites. More importantly, the
derived JPDFs are applied to estimate the direction-related wind power
density at each of the considered sites, finding a maximum value of wind
energy potential of 506.4 W/m2 at a hilltop site. In addition,
site-to-site variability is also identified regarding the prevailing
wind resource directions. The outcome of this study is expected to be
useful for the site selection of wind turbines, as well as the strategic
development of wind energy in Hong Kong. Notably, the proposed
copula-based method can also be applied to characterize the
direction-related wind energy potential somewhere other than Hong Kong.
Call to Action: Harmonisation of Pharmacovigilance Regulations for Post-marketing Pregnancy and Breastfeeding Safety Studies
Authors: Alexe Amalia , Eisele Osa , Fernandes Maria Fernanda Scantamburlo , Lewis David , Abramova Nadezda , Balramsingh-Harry Leesha , Garg Anju , Kovacs Birgit , Wurst Keele , Zheteyeva Yenlik
Published: December 2022

Globally, more than 200 million women become pregnant each year, most of
whom receive medications despite limited information on their safe use
during pregnancy. The paucity of drug safety data on pregnant and
breastfeeding women stems from the routine exclusion of this population
from clinical trials due to scientific, ethical, regulatory and legal
concerns. Consequently, at the time of initial drug approval, there may
be scant safety data to inform the drug benefit-risk balance to the
mother, foetus, or infant. Although momentum is growing to include this
underrepresented population in clinical trials, most information on drug
exposure outcomes comes from data collected in the post-marketing
setting. Regulatory guidance and legislation on medication use in
pregnancy and breastfeeding were reviewed globally by TransCelerate IGR
PV Pregnancy and Breastfeeding Team. ICH standards and CIOMS guidelines
served as benchmarks for national safety regulations and guidance. The
landscape assessment identified a lack of harmonisation of global
regulations on research in pregnant and breastfeeding women. This
editorial focuses on the ambiguities and lack of harmonisation in global
regulations on post-marketing pregnancy and breastfeeding safety
studies. There is currently no ICH standard to guide these types of
safety studies and, in most regions reviewed, there are no clear
regulations or guidance on when and how to conduct them. While a
challenging undertaking, greater clarity and harmonisation would
facilitate more timely completion of post-marketing pregnancy safety
studies that would ultimately generate the critical data needed to
optimize benefit-risk decisions for pregnant and breastfeeding women.