bluuebunny/crossref_metadata_2025 huggingface dataset:
SOSIALISASI PENGOLAHAN LIMBAH PLASTIK MENJADI WASTAFEL SEBAGAI SARANA CUCI TANGAN DI PONDOK PESANTREN NURUL IJTIHAD AL-MA’ARIF NU DESA KUTA KABUPATEN LOMBOK TENGAH
Authors: Littaqwa Lalu Auliya Akraboe , Ramdlan M. Said , Saputri Legis Ocktaviana
Published: June 2023

Cuci tangan mudah dilakukan, bahkan pemerintah mengajak warga untuk membuat tempat cuci tangan sendiri. Pemanfaatan limbah plastik dapat dilakukan dengan mudah dan murah. Sampah plastik menjadi bagian yang tidak terelakkan saat ini termasuk di kawasan Kuta Mandalika. Terjadi peningkatan timbulan sampah 2.815 kg/hari dari tahun 2016-2018 termasuk sampah plastik, membuktikan penanganan sampah belum efektif. Upaya memanfaatkan limbah menjadi barang bernilai perlu diajarkan sejak dini untuk meningkatkan kesadaran akan potensi limbah plastik. Bagaimana perspektif santri dalam menanggapi limbah plastik. Untuk mensosialisasikan pemanfaatan limbah plastik menjadi barang bernilai serta pemanfaatan penggunaan air bersih. Kegiatan dilakuan di Ponpes Nurul Ijtihad Al-Ma’arif NU Desa Kuta Kabupaten Lombok Tengah metode pelaksanaan kegiatan berupa persiapan, pelaksanaan dan finishing. Persiapan berupa koordinasi dengan pihak terkait dalam mempersiapkan kegiatan sosialisasi. Selanjutnya pelaksanaan berupa pembuatan sarana cuci tangan dari limbah plastik. Pembuatan sarana cuci tangan didesain menarik dengan memanfaatkan limbah plastik. Media sarana cuci tangan dipasang cara cuci tangan yang benar menurut WHO (World Healt Organization). Sosialisasi yang dilakukan di Ponpes Nurul Ijtihad Al Ma’arif Desa Kuta Kabupaten Lombok Tengah berjalan lancar. Kegiatan sebelum dilakukannya sosialisasi sebanyak 46% santri dan santriwati mengetahui limbah plastik bisa menjadi barang yang lebih bernilai. Setelah dilakukan sosialisasi peningkatan menjadi 55,67% mengetahui limbah plastik menjadi barang bernilai. Sebanyak 98% santri dan santriwati mau melakukan salah satu prinsip 4R (reuse, reduce, recycle, replace) dan sisanya tidak mau melakukan. Santri sebagian besar memahami potensi limbah plastik yang bernilai berupa tempat cuci tangan Keterbatasan pengetahuan, keterampilan, dan sulit dalam melawan rasa malas alasan santri tidak mau melakukan kegiatan 4R.
Pengaruh Angin Muson Australia Terhadap Sifat Hujan Pada Musim Kemarau di Wilayah Lombok
Authors: Hidayatun Nufus  , I Nyoman Soemeinaboedhy  , Mahrup  , Baharuddin
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh angin Muson Australia yang bertiup dari pantai barat Australia Barat dan Benua Australia terhadap sifat hujan pada Musim Kemarau di Pulau Lombok. Penelitian ini dilaksanakan dari bulan Agustus 2022 sampai dengan bulan Desember 2022. Area penelitian meliputi kawasan Pulau Lombok, kawasan Muson Australia, peraiaran samudera Hindia di pantai barat Australia Barat dan kawasan Benua Australia. Penelitian ini menggunakan metode Deskriptif, melalui tahapan sebagai berikut, yaitu (i) Pengumpulan data sekunder, (ii) Analisis data dan (iii) interpretasi data. Data yang digunakan dalam penelitian ini terdiri dari data sekunder. Data sekunder yaitu data data curah hujan, data tekanan udara, suhu udara, kelembaban udara, kecepatan dan arah angin yang di unduh dari website https://power.larc.nasa.gov/data-acces-viewer/. Hasil dari penelitian ini adalah terdapat hubungan yang signifikan antara sifat hujan pada musim kemarau di pulau Lombok dan Angin yang berasal dari Pantai Barat Australia dan Benua Australia. Angin Muson Australia yang bersifat kering menyebabkan Lombok mengalami hujan di bawah normal, sebaliknya jika bersifat lembab maka Lombok akan mengalami hujan di atas normal. Angin kering terbentuk ketika suhu udara berada dibawah rata-rata, tekanan atas rata-rata dan kelembaban dibawah rata-rata, sebaliknya angin lembab terbentuk ketika suhu udara di atas rata-rata, tekanan di bawah rata-rata dan kelembaban di atas rata-rata. Arah angin  yang lebih dominan mengarah ke barat atau barat laut berpotensi membawa uap air menjauhi wilayah Indonesia, dengan demikian menimbulkan sifat kemarau kering di Lombok.
PREVENÇÃO E CUIDADOS GINECOLÓGICOS: PROMOVENDO O BEM-ESTAR DA MULHER
Authors: Tuyama Marina Gontijo , PEDROSA ANA BEATRIZ VIANNA , MOREIRA GIOVANA SENA VELOSO STEFANI , BAHIA LORENZA TAVARES BRASIL , Frattari Ana Laura Vaz de Mello , FIUZA SÉRGIO BOTELHO , DUARTE JOÃO CAETANO BARBOSA , BATISTA ROBERTA STHEFANIE ALVES LAFETÁ , ALMEIDA CAMILA LAMOUNIER LELLIS DE , MELO MARINA VIANA
Published: June 2023

Este artigo aborda a importância da prevenção e dos cuidados ginecológicos para promover o bem-estar da mulher. São discutidos temas como a realização de exames de rotina, a eficácia das medidas preventivas, o impacto dos hábitos saudáveis na saúde ginecológica, a importância do acesso a serviços de saúde ginecológica e os benefícios do diálogo aberto e do autocuidado. A realização de exames de rotina é fundamental para a detecção precoce de doenças, enquanto medidas preventivas, como vacinação e uso de métodos contraceptivos, ajudam a evitar problemas de saúde. Hábitos saudáveis, como uma alimentação equilibrada e exercícios regulares, têm um impacto positivo na saúde ginecológica. Além disso, o acesso a serviços de saúde ginecológica e o diálogo aberto com profissionais de saúde são essenciais para garantir cuidados adequados e personalizados. O autocuidado, por sua vez, empodera as mulheres a assumirem um papel ativo na promoção de sua própria saúde. Investir em estratégias de prevenção, educação e acesso equitativo a serviços de saúde é fundamental para garantir o bem-estar das mulheres em relação aos cuidados ginecológicos.
Palavras Chave: Prevenção ginecológica. Cuidados ginecológicos. Bem-estar da mulher.
Fitoplâncton e variáveis físico-químicas na região costeira do Caúra, Baía de São José - MA
Authors: Oliveira Ana Virgínia Gomes de , Cutrim Andrea Christina Gomes de Azevedo , Batista Raissa Nyra da Silva , Bastos Roberth dos Santos , Rosas Rayane Serra , Cutrim Marco Valério Jansen , Sá Ana Karoline Duarte dos Santos
Published: June 2023

A Zona Costeira Maranhense apresenta uma variedade de ecossistemas de grande importância ambiental e nela encontra-se a baía de São José, situada ao nordeste do Maranhão, fazendo parte de um dos grandes complexos estuarinos que formam o Golfão Maranhense. A alta produtividade biológica deste ambiente deve-se principalmente ao fitoplâncton, por constituir a base da teia trófica dos ecossistemas aquáticos. Dessa forma, este estudo teve como objetivo avaliar a composição do fitoplâncton na região costeira do Caúra, São José de Ribamar - MA. Quatro campanhas amostrais foram realizadas nos períodos de pico da estiagem (PE), início da chuva (IC), pico da chuva (PC) e início da estiagem (IE), em três pontos amostrais. Para as variáveis ambientais, as amostras foram coletadas na sub-superfície da água e aferidas com o multiparâmetro, refratômetro e disco de Secchi. Amostras qualitativas do fitoplâncton foram realizadas com auxílio de rede cônico-cilíndrica. Para as análises quantitativas foi utilizada a técnica de sedimentação, transectos em cruz no microscópio invertido. A clorofila a foi analisada através do método espectrofotométrico. 81 táxons foram registrados no Caúra, com predomínio da divisão Bacillariophyta. Quanto ao índice de constância, as espécies que se destacaram em 100% das amostras foram Synedra tabulata, Synedra sp2, Coscinodiscus oculus-iridis e Coscinodiscus sp. A análise da clorofila a revelou valores maiores no pico da estiagem, enquanto a densidade apresentou-se maior durante o pico da chuva. A Análise dos Componentes Principais mostrou que a densidade fitoplanctônica correlacionou-se positivamente com o nitrogênio total e a amônia e negativamente com a salinidade, o pH, o fósforo total e o microfitoplâncton. O ambiente mostrou-se muito produtivo, onde o manguezal e a praia estavam aparentemente saudáveis. Entretanto, na região portuária, a intervenção antrópica foi verificada devido a intensa movimentação de embarcações, ao tratamento de pescados e ao acúmulo de resíduos sólidos.
Interação entre os parâmetros abióticos e a comunidade de zooplâncton na região do Caúra, Complexo Estuarino de São José - MA
Authors: Rosas Rayane Serra , Cutrim Andrea Christina Gomes de Azevedo , Cutrim Marco Valério Jansen , Sá Ana Karoline Duarte dos Santos , Alves Jálisson de Sousa , Oliveira Ana Virgínia Gomes de , Lima Ingrid Caroline Moreira , Pinheiro Thiago Ferreira
Published: June 2023

Esta pesquisa foi realizada na região do Caúra, Complexo Estuarino de São José (CESJ), com coletas realizadas em maré de sizígia, nos períodos de estiagem (PE), início de chuva (IC), chuvoso (PC) e início de estiagem (IE), junto às análises das variáveis físico-químicas da água em três pontos amostrais: Porto do Vieira (P1), Manguezal do Caúra (P2) e na Praia do Caúra (P3), por meio do arrasto da rede do zooplâncton (120 µm) com fluxômetro acoplado em que as amostras foram acondicionadas em frascos plásticos e fixadas no formol a 4% para as análises laboratoriais. Na área de estudo, as variáveis físico-químicas não apresentaram grandes variações entre os pontos amostrais, com exceção da transparência da água, que se mostrou mais elevada no ponto P3. A comunidade de zooplâncton foi representada por 42 táxons, na qual as famílias Paracalanidae e Oithonidae obtiveram a maior número de espécies identificadas, representadas especialmente pelo grupo dos copépodes, que correspondeu a 69% da comunidade zooplanctônica. Nos índices ecológicos, a diversidade se expressou média durante o PE e PC e elevada nos períodos IC e IE; a equitabilidade se mostrou elevada; já a riqueza se constituiu em altos valores durante o período estudado. As análises de significância (ANOVA e Kruskal-Wallis) e ACP expressam que, com o aumento da pluviosidade, a densidade da comunidade de zooplâncton, temperatura, pH e salinidade (p<0,05) diminuiu apontando a influência das chuvas nas variáveis físico-químicas da água, alterando a biota de forma quali-quantitativa durante o estudo. Do mesmo modo, a riqueza da comunidade se elevou, mostrando uma relação inversa com o nitrogênio total e a transparência da água (p<0,05).
Nivel de conocimientos, actitudes y aptitudes en infecciones intrahospitalarias del personal asistencial de un hospital de baja y uno de alta complejidad, en Antioquia
Authors: Caro-Londoño Anyi Melissa , Guzmán-Cardona María Alejandra , Vega-López Maciel Alejandra
Published: June 2023

Introducción. Según la Organización Mundial de la Salud, en instituciones de países en desarrollo las infecciones nosocomiales podrían superar el 25%; en Colombia, en 2012 estas representaban el 4.7% de las causas de muerte según Secretaría de Salud de Bogotá. El Ministerio de Salud señaló a Antioquia como el departamento con la tasa más alta en Infecciones Asociadas a la Atención en Salud (IAAS). Objetivo. Evaluar el nivel de conocimientos, actitudes y aptitudes en IAAS por parte del personal asistencial de un hospital de baja y uno de alta complejidad, en Antioquia. Metodología. Estudio descriptivo transversal, 66 participantes entre médicos, auxiliares de enfermería y enfermeros de urgencias y hospitalización. Intervalo de confianza del 90%.  Criterios de inclusión: llevar mínimo tres meses trabajando en el hospital, en todos los tipos de contratación. Exclusión: no aceptar participación y personal asistencial con funciones administrativas. Se aplicó un instrumento con preguntas cerradas sobre los conocimientos, actitudes y aptitudes en IAAS. Resultados.  Enfermería tuvo mayor nivel en conocimientos, auxiliares de enfermería en prácticas y los médicos tuvieron menor puntaje con un 24%. En actitud, el personal de ambos hospitales percibía las actividades asociadas a la atención en salud como importantes, pero rutinarias. Discusión El componente de conocimientos representa el mayor problema para la población, más específicamente la temática sobre lavado de manos, los médicos presentaron mayor número de puntajes por debajo del 60%. Conclusiones.  El estudio sugiere que los profesionales de ambos hospitales, independientemente de su profesión, poseen mejores bases prácticas que teóricas, la actitud no parece tener relación con las otras variables.
Herida por asta de toro en el medio rural. Importancia de la preparación en cirugía taurina: Reporte de caso
Authors: Cabrera-Vargas Luis Felipe , Aparicio-Blanco Brandon Steven , Pedraza-Ciro Mauricio , Báez-López Dayana Katerin , Cabrera-Silva Laura Alejandra , Perilla-Martínez José Luis
Published: June 2023

Introducción. El trauma abdominal penetrante causado por embestida de asta de toro representa menos del 3%. Son heridas que deben ser consideradas sucias, y la primera causa de muerte por este tipo de trauma es el shock hipovolémico. Presentación de caso. Se presenta el caso de un hombre de 60 años con trauma abdominal penetrante por asta de toro en flanco izquierdo e hipogastrio de 18x8 cm de extensión, con evisceración aguda traumática. Fue llevado a laparotomía exploratoria, donde no se evidenciaron lesiones de órganos sólidos ni de vísceras huecas. El paciente evolucionó sin complicaciones. Discusión. Las heridas por asta de toro dadas sus características son consideradas sucias y alcanzan hasta un 50% de infección. Dentro de su manejo inicial se deben incluir antibióticos y abordajes quirúrgicos, según cada caso. Conclusión. El trauma abdominal penetrante causado por embestida de asta de toro es un mecanismo poco frecuente; sin embargo, los cirujanos deben estar entrenados para tratar o no de manera quirúrgica a este tipo de pacientes.
Manejo laparoscópico de las hernias ventrales mediante abordaje totalmente extraperitoneal (eTEP): experiencia inicial y resultados a corto plazo
Authors: Trujillo-Díaz Jeancarlos Jhosmer , Gómez-López Juan Ramón , Concejo-Cutoli Pilar , Martínez-Moreno Clara , Atienza-Herrero Javier , Martín-del Olmo Juan Carlos
Published: June 2023

Introducción. El manejo de la hernia ventral sigue siendo un desafío para los cirujanos. Su reparación mediante técnicas mínimamente invasivas, como la totalmente extraperitoneal (eTEP) laparoscópica, permite una amplia disección del espacio a reparar, una recuperación postoperatoria más rápida, menor dolor postoperatorio y estancia hospitalaria. El abordaje eTEP es un enfoque novedoso que utiliza el espacio retromuscular para colocar material protésico y fortalecer la pared abdominal. El objetivo es describir los resultados a corto plazo de nuestra experiencia inicial con la técnica eTEP en el manejo de las hernias ventrales. Metodología. Estudio observacional, descriptivo, retrospectivo, donde se incluyen pacientes con el diagnóstico de hernia ventral, sometidos a cirugía laparoscópica-eTEP, entre julio-2021 y junio-2022. Resultados. De un total de 21 pacientes, el 61.9% fueron hombres. El 47.6% tenían sobrepeso y el 52.4% obesidad. Estancia hospitalaria media: 1.6 días. El 66.7% fueron hernias incisionales. Las técnicas quirúrgicas realizadas fueron: Rives-Stoppa (71.4%) asociándose liberación del músculo transverso en el 28.6%. El 19% de los pacientes presentaron complicaciones globales y solo uno fue grave, requiriendo reintervención quirúrgica. Se observó la presencia de seroma clínico en el 9.5% y ecográfico en 57.1%. No se evidenciaron hematomas, infección de herida quirúrgica ni casos de recidiva herniaria. Discusión y conclusiones. El abordaje laparoscópico eTEP Rives-Stoppa, asociado o no a separación posterior de componentes, en el manejo de las hernias ventrales ofrece buenos resultados asociando una baja incidencia de complicaciones postoperatorias, corta estancia hospitalaria, baja incidencia de recidivas herniarias, por lo que podría considerarse una técnica segura y efectiva en el tratamiento de las hernias ventrales.
MedUNAB, 25 años publicando sueños
Authors: Cadena-Afanador Laura Del Pilar
Published: June 2023

“MedUNAB ha sido y sigue siendo una escuela de vida. No solo de vida académica o científica, sino también de esa vida que propone, gestiona y se relaciona. Una escuela que a muchos nos ha permitido ver el panorama y proyectarnos para capitalizar nuestras capacidades y cumplir con los sueños. Pero, sobre todo, para crecer y ser mejores profesionales, mejores felices seres humanos. Se han construido amistades perennes y, por qué no decirlo, amores auténticos. Solo queda agradecer la oportunidad, que ha moldeado mucho de lo que se es y de lo que hemos podido aportar.” Con las palabras del segundo editor de la revista, Luis Alfonso Díaz Martínez, quiero iniciar esta reseña, que más que un recuento histórico, es la remembranza de una institución que tiene vida propia al interior de la Facultad de Ciencias de la Salud de la Universidad Autónoma de Bucaramanga (UNAB).
Innovations and New Technologies in Gastrointestinal Surgery
Authors: Kroh Matthew
Published: June 2023

Introduction. Innovations in surgery have advanced significantly in the last decade. The new technologies in minimally invasive surgery, including robotics, advanced endoscopy, and the progress in artificial intelligence and machine learning are impacting gastrointestinal surgery and medicine. These technologies have been available since 1956, and in the early 1970’s, they were implemented for first time with the Mycin system, which was developed to detect infectious diseases in blood. Objective. To describe the experiences of new technology innovations in surgery, in terms of novel interventions, development of devices, and the process of adopting these technologies in the clinical practice. Methodology. Personal reflections about the process of adopting new technologies in surgery and its future implications, documented from my perspective as an academic surgeon. Results and discussion. This article summarizes the most relevant advances in the field of gastrointestinal surgery during the last decade. Conclusions. Adopting a culture of innovation in surgery involves knowledge of the process, technical resources available to support initiatives, access to mentors or tutors, and support services.
Igreja na América Latina e a Promoção Humana
Authors: Sales Eugênio de Araújo
Published: June 2023

A Segunda Conferência Geral do Episcopado Latino-Americano, inaugurada na Colômbia no dia 24-8-68 sob a Presidência do Santo Padre, é chamada a reexaminar a missão da Igreja em face das transformações globais da América Latina. Ela assume, portanto, responsabilidade providencial e indiscutível no aperfeiçoamento das tarefas eclesiais, em seus métodos de ação, na formação das consciências...
Secularização e Culto
Authors: Lepargneur Francisco Hubert
Published: June 2023

Segundo Harvey Cox, a secularização consiste nesse «processo histórico quase que certamente irreversível no qual a sociedade e a cultura são libertadas da tutela do controle religioso e das concepções metafísicas rígidas do mundo». Êste movimento afeta teórica e praticamente o culto cristão, sua concepção em largos setores da população, a percepção de sua necessidade, o seu exercício concreto. Ninguém nega a importância dêste problema na evolução atual do Cristianismo. As soluções mais desencontradas são indicadas a êsse respeito. Queremos fazer algumas observações para esclarecer o assunto...
Triple X syndrome and various abnormality of 3q in Iraqi women: a case report
Authors: Ismail Noor H.
Published: June 2023

Triple X syndrome 47XXX is a sex chromosome abnormality characterized by presence of an extra X chromosome. Most of the girls born with triple X chromosomes have no signs or symptoms at birth. The condition often remains undiagnosed until adulthood when the genetic defect is discovered on investigation for other reasons as in this case of a 52 year old lady who diagnosed with systemic lupus erythematosus (SLE). The chromosomal analysis for peripheral blood cells by using Gbanding technique revealed trisomy X and various abnormality of 3q karyotype. Chromosomal analysis was also done for two daughters and one son of the patient that showed normal karyotype. In conclusion our findings provide additional support for the hypothesis that X-chromosome polysomy may confer increased susceptibility to SLE. The association of SLE with chromosomal abnormality of 3q found in our patient needs further studies to uncover the role of genes affected by this aberration in SLE.
Incidence of Epstein Barr Virus infection in newly diagnosed non-Hodgkin lymphoma in the national center of hematology-single center study
Authors: Alwan Alaa Fadhil
Published: June 2023

Background: Non Hodgkin lymphoma (NHL) is a diverse group of disorders both in their original history and in response to therapy .The appearance of Epstein-Barr infection (EBV) in Non-Hodgkin’s lymphoma (NHL) could be distinguished by enzyme link immune sorbent assay by detecting IgM and IgG. The role of EBV as causative agent for non-Hodgkin lymphoma has been supported by identification of large amounts of latent membrane protein 1 (LMP-1) outflow in tumors. The aim: of this study was to determine the incidence of EBV infection in patient with newly diagnosed patients with nonHodgkin lymphoma. Materials and Methods: This study was done at the Department of clinical hematology, the national center of hematology (NCH), Baghdad, Iraq from August 2012 to November 2013. It is a prospective study. A total of 56 patients with age ranged from 18 – 56 years were included. They were diagnosed with NHL and then classified to subtypes by studying histopathology and immunohistochemistry. Assessment of EBV IgM and IgG were done by ELISA technique. A second group comprised of 22 patients with non-malignant condition regarded as control group with matched sex and age. Statistical analysis was performed utilizing SPSS version 17.0. Result: Mean age of the patients was 51.44±15.93 years. Thirty-six (70.4%) were males and 20 (29.6%) were females. Seven (12.5%) out of 56 cases were positive for EBV–IgM, two cases (28.5%) were follicular lymphoma, 5 cases (71.5%) were diffuse large B cell lymphomas. For the EBV-IgG 12 patients (21.4%) were negative while majority 44 patients (78.6%) were positive, in comparison to control group the result was statistically not significant. Conclusion: This study showed that the age, sex and clinical characteristics of Iraqi patients with NHL are different from those of surrounding countries and. The incidence of EBV is high in NHL. The most frequent subtype of NHL is diffuse large B cell lymphoma
Caspase-3 apoptotic induction by Iraqi Newcastle disease virus on mammary adenocarcinoma transplanted in mice
Authors: Al-Shammari Ahmed Majeed
Published: June 2023

This study aimed to investigate the ability of Iraqi strain of Newcastle Disease Virus (NDV) to induce apoptosisin vivothrough Caspase 3 activation when administered intratumoral and compared to intra-peritoneal injection.Immunohistochemistry test was used for detecting apoptosis by using mAb against Caspase-3. Histopathological sections for the treated tumor mass showed proliferation of granulation tissue with extensive area of necrosis (mixture of apoptotic and necrotic cells).This revealed that NDV infection induce apoptosis significantly in mammary adenocarcinoma (AM3) when compared to control group proved by high expression of caspase-3.In vivo immunohistochemical detection of Caspase 3in mammaryadenocarcinoma which give brown stain revealed a significantly(p<0.05)increase in the mean percentage of cells expressing caspase 3 in NDV treated group compared with low increase in the mean percentage of cells expressing caspase 3 in untreated control group at day 1,2,3,7, and at 14 day. These results revealed that NDV had powerful effect on inducing apoptosis in mammary adenocarcinoma (AM3) during its replication inside the tumor mass for long time after one single injection. This study indicate the role of NDV Iraqi strain in inducing apoptosis as confirmed by caspase-3 activation in cancer cells which is interesting confirmed feature that make NDV Iraqi strain as anti-tumor agnet.
Detection of some microRNAs expressions in tissues of British Women diagnosed with Breast cancer
Authors: Saad Zaynab
Published: June 2023

MicroRNAs (miRNAs) are small, non coding RNA, found to play critical roles in tumor progression. The aim of this project was to investigate the expression of miR-21, miR-26b, miR-429 and miR-378 in human breast cancer tissues. By using TaqMan qRT-PCR assay to detect the expression of these selected miRNAs in 12 pairs of breast cancer tissues and their corresponding noncancerous breast tissues. Data indicated that the relative level of miR-21 was up regulated in cancer tissues (p 0.0014), miR-26b was significantly down regulated in breast cancer tissues (p 0.0017), While the novel expression of miR-429 was significantly up regulated in breast cancer tissues (p 0.0131) and novel down expression of miR-378 in breast cancer tissues (p 0.0006). These microRNAs might be a potential molecular biomarker for early detection of breast cancer in women
Survival of patients with multiple myeloma diagnosed at the national center of hematology in Baghdad
Authors: Alwan Alaa Fadhil
Published: June 2023

Multiple myeloma (MM) is a monoclonal malignant proliferation of plasma cells derived from a single clone. Due to the variety of organ dysfunction caused by this malignant disease with no curative therapy, hence survival becomes a challenge for this group of patients. The aim of this study was to analyze the epidemiology and survival of patients with MM attended the out-patient clinic of the national center of hematology in Baghdad/Iraq. A retrospective study conducted at the national center of hematology, from September 2009 to November 2013 in which the medical records of 46 patients with MM have been reviewed. Survival analysis was estimated by the Kaplan-Meier and multivariate Cox regression analysis. The mean age was 63.4 years, and 54.2% of patients studied were female. The most common clinical manifestations were anemia (93.4%), bone pain (86.9%), and renal impairment (39.1%). In survival analysis, the only variable that achieved statistical significance was renal impairment (p = 0.025). For mortality, renal impairment (p = 0.017) and coagulation abnormalities (p = 0.012) were significant in the Cox regression. In conclusion the epidemiological profile showed a slight predominance in females. Anemia and bone pain were the most frequent complaints. Renal impairment and coagulation abnormalities were associated with mortality for patients with multiple myeloma
Expression of Cytokine of Chronic Lymphocyte Leukemia from Baghdad / Iraq Population
Authors: Ahmed Najwa Sh.
Published: June 2023

Aim of the current study is to investigate correlation proinflammatory cytokines (Interleukin 6, 8, 10, and TNF α) with Chronic Lymphocyte Leukemia. In this study, serum was collected from (100) sample, a representative of 80 samples of chronic lymphocyte leukemia who were newly diagnosed by the consultant medical staff at the National Center of Hematology and 20 healthy sample on the other hand. IL-6, IL8, IL10 and TNF α were studied using the enzyme linked immunosorbent assay methods from (R and D system/USA). This study have shown that IL6 levels increased about two fold compared with healthy groups and TNF α levels was three times higher in CLL patient compared with healthy and IL10 levels was 3.5 fold that healthy. The conclusion IL 6, 10, and TNF α levels have significantly increased in patients compared with healthy control. However, IL8 was the same production in CLL compared with control.
Ameliorating the anticancer drug ”Adriamycin” acute Cardiotoxicity by Rosuvastatin and Telmisartan in rats
Authors: Ahmed Ihab A.
Published: June 2023

Adriamycin, an anthracycline antibiotic is a powerful antineoplastic drug, but its therapeutic usefulness is limited by its cardiotoxicity. The present study investigated the effects of pretreatment with rosuvastatin and telmisartan alone or in combination against adriamycin induced cardiotoxicity in rats using biochemical approaches. The animals were divided into eight groups of 5 animals each. The first group received no drug(s) po but a single dose of distilled water (7.5 ml/kg, ip) at day eight, which serves as the control group. The second group received no drug(s) po but a single dose of adriamycin (15 mg/kg, ip) at day eight, and serves as adriamycin only received group. The third and sixth group received rosuvastatin (2 , 10) mg/kg/day respectively for nine days, and on day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. The fourth and seventh group received telmisartan (2 , 4) mg/kg/day respectively for nine days, and at day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. The fifth and eighth group received both drugs, where the fifth group Received both of rosuvastatin (2 mg/kg, po) and telmisartan (2 mg/kg, po), 1 hour apart, daily for nine days, and on day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. While the eighth group received both of rosuvastatin (10 mg/kg, po) and telmisartan (4 mg/kg, po), 1 hour apart, daily for nine days, and on day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. At day ten of the study, blood samples were taken for biochemical analysis. Rats treated with adriamycin showed cardiotoxicity as evidenced by elevation of serum lactate dehydrogenase (LDH) activity, serum malondialdehyde (MDA) level, cardiac troponin (CTn-I) level and interluekine 17(IL-17) level. Pretreatment with rosuvastatin and telmisartan alone or in combination elicited a significant decrease in the activities of all markers measured in comparison with adriamycin treated group. These results suggest that both rosuvastatin and telmisartan treatment provides a significant protective effect against acuteadriamycin induced cardiotoxicity in rats.
Level of placental trophoblastic KISS1 protein is associated with high risk of recurrent spontaneous abortion in Iraqi women
Authors: Jawad Rana S.
Published: June 2023

Introduction: Recurrent pregnancy loss is the syndrome that causes repeated miscarriage and/or stillbirth impairing the ability to have a live birth. More from research interest has been focused on the association studies between different factors and recurrent spontaneous abortion. The aim of this study was examine the role of alteration in levels of KISS1protein and in recurrent spontaneous abortion (RSA). Methods: Level of KISS1 protein was detected by immunohistochemical examinations in samples from placenta and measurement the levels of Follicle stimulating hormone (FSH) , Luteinizing hormone (LH) by using Enzyme linked Fluorescent Assay (ElFA) technique of groups I (women pregnant were normal delivered pregnancy at delivery in the third trimester (n=15); II refer to normal pregnant in first trimester (n = 15) (I ;II control group)., III represented aborted women for the first time during the first trimester (n = 15.( and group (IV): (30) represented repeated aborted women during the first trimester Results: Finding from this study revealed that the level of the protein was high in abortion groups and increased levels of LH and FSH as well. Conclusion: Kisspeptine is implicated in RSA through inhibition of normal placentation and indirectly through stimulation of LH and FSH secretion.
Antiproliferative Effects and Apoptosis induction of Ethanolic Extract of Andrachna aspera on Human Rabdomyosarcoma Cells
Authors: Hidayat Hazha J.
Published: June 2023

Arial part of Andrachna aspera ethanolic extract was evaluated by studying their effect on human rabdomyosarcoma (RD) cell line. The cytotoxic activity was determined by anti-proliferative effects when the human rabdomyosarcoma cells were cultured under different concentrations. After 24, 48 and 72h when treated with the ethanolic extract, using cell viability assay. The plant extract showed the strong cytotoxic affect upon the cell like RD with IC50 of 25 µg/ml concentration after 72h, Furthermore, cell cycle analysis showed a significant increase in the accumulation of RD- treated cells at G0/G1 phase (p<0.01), and apoptotic rate also shows significantly increasing in a dose- time dependent manner.The extract of A. aspera induced apoptosis and possessed the most robust anticancer activity, against RD cells
Embryonic Markers association in Mice Bearing Mammary Adenocarcinoma (AN3) transplantable tumor model
Authors: Alshammari Ahmed Majeed
Published: June 2023

AN3 tumor model had special importance as breast cancer model to evaluate new and novel therapeutic agents and there is need to study the tumor associated markers presence during AN3 tumor growth. Most common markers are Carcinoembryonic antigen (CEA) and α-fetoprotein (AFP) which are cells surface glycoproteins. Oncofetal antigens involved in cell adhesion marker for cancers diagnosis and prognosis and normally they are not present in the blood of healthy adults. AN3 is transplantable mammary adenocarcinoma tumor used as in vivo model for years in cancer research for human breast cancer. Hence studying the presence of associated tumor antigens that extensively used as tumor markers (AFP and CEA) is necessary to characterize the model and determine the usefulness to use them as follow up markers after testing therapeutic agents in this model. Healthy and pregnant healthy female mice were used as control groups and AN3 transplanted mice measured after tumor grow to reach at least 0.5 cm. The results showed that CEA is markedly high in mice bearing tumors while no presence of it in both control groups. AFP had a different picture as the higher percentage was in the pregnant females, which is very normal because AFP is a fetal protein, but mice bearing tumor significantly higher concentration than healthy mice. In conclusion, AFP and CEA are useful markers to be used for AN3 model in experimental evaluation of novel therapies follow up
Immunophenotyic profile of adult acute lymphoblastic leukaemia in Iraq, a one year experience
Authors: Al-Bayaa Israa M.
Published: June 2023

Background: Acute lymphoblastic leukaemia accounts for approximately 14% of leukaemia cases in the adults with B linage subtype being more common than T linage subtype. immnophenotyping using the multicolour flow cytometry is an essential tool for diagnosis, classification as well as treatment guidance and prognosis. Objectives: This study aims to provide an overview of the immunophenotypic profile of adult ALL cases in Iraq, it’s possible link with other characters and also study the frequency of expression of aberrant myeloid antigens in them. Patients and methods: this is a descriptive study included 64 adult patients diagnosed as ALL in haematology unit at Baghdad teaching hospital for the period between May 2014 till May 2015 , immunophenotyping was carried out at the flow cytometry laboratory in the nursing home hospital using 6 coloured (BD-FACS-Canto II System from Becton Dickenson). Results: of the study population 63.7% of the cases were B-ALL and 27.5% were T-ALL, there was no significant difference in respect to age and gender between them. Of the CD markers used both CD10 and CD34 were significantly associated with B-ALL compared to T-ALL (p values 0.002 and 0.003 respectively).aberrant myeloid Ag expression was seen in 43.18% of B-ALL cases and in 52.6% of T-ALL cases with no significant difference however aberrant myeloid Ag expression was significantly associated with CD34 expression with a p value of 00.018. Conclusion: Immunophenotyping retains a crucial place in the work up for patients with acute lymphoblastic leukaemia. CD34 was significantly associated with B linage ALL and with aberrant myeloid Ag expression, larger study with clinical evaluation and cytogenetic study is recommended to evaluate the impact of those findings over prognosis.
Study The Effect of Purifed Goat Milk Lactoferrin on HeLa Cancer Cell line Growth In vitro
Authors: Abbas Zainab H.
Published: June 2023

Lactoferrin is an important protein in many biological applications as a potential cancer treatment agent .In this study, lactoferrin was purifed from goat colostrum by Ion exchange chromatography by using CM-Sephadex G-150 column and gelfltration by using Sephadex G-200 column .To evaluted its ability as anticancer agent the study utilized an in vitro evaluation for the cytotoxic effect of the purifed goat milk lactoferrin (gLf) on two cell lines, HeLa (Human cervical cancer) cell line and Rat Embryo Fibroblast (REF) cell line at different concentrations and different exposure time of treatment. The purifed gLf concentrations ranging (19.53 to 5000) μg/ml for 24,48 and 72 hours. The effect of gLf was evaluated by employing MTT assay. The results revealed signifcant cytotoxic effect at levels (P<0.05) for all concentrations and for all exposure time of gLF on HeLa cell line as compared to untreated control cells, The inhibition rate IR% increased with raising of gLF concentration and incubation period The highest inhibitory growth was at the concentration ( 5000 µg/ml) after 72hrs of exposure time (64.38%) ,while only the highest concentration gave signifcant inhibitory effect (P< 0.05) with normal cell REF .
Phytochemical screening and effects of aqueous extracts of Cymbopogon citratus(DC) Staptand Origanum vulgare (LINN) on the biochemical and haematological profileof Wistar strain albino rats
Authors: Aminat Omope Yusuf  , Emily Akubia Nzeribe  , Patience Ogbenyeanu Nwadiaro  , Timothy Olugbenga Ogundeko  , Ethel Ihemjiaba Ekam  , Ene Patricia Ejembi  , Festus Chukwuemeka Onwuliri  , Cornelius Sunday SaliuBello
Published: June 2023

Medicinal plants have played a major role in the field of medicine as alternative therapy to orthodox drugs. This present study aimed to evaluate the acute toxicity of Cymbopogon citratus and Origanum vulgare aqueous extracts on albino rats.The qualitative phytochemical analyses of the was done using standard procedures. The LD50 was determined using modified Lorke’s method, while the biochemical and haematological analysis were done by automated methods. Results from phytochemical analysis reveals the presence of Alkaloids, Flavanoids, Phenols and tannins, Steroids and sterols, Carbohydrates, Saponins, Protein and amino acid and Anthraquininein the two extracts. Furthermore, the electrolytes(urea and creatinine) were within the normal range in rats of the control and the orally administered aqueous extracts of Cymbopogon citratus and Origanum vulgare (100 mg/kg, 200 mg/kg and 400 mg/kg). Total protein, alkaline phosphate, total bilirubin, conjugate bilirubin, alanine aminotransferase, albumin and Aspartate aminotransferase were also within the normal range in both control and groups treated with 100mg/kg and 200mg/kg and 400mg/kg. White blood celland platelet followed same trend of falling within the normal range while Packed cell volume, Haemoglobin values were higher than the normal range across the control and test groups. Aqueous crude extracts ofC. Citratusand O. vulgarecontain primary and secondary metabolites thus with potential medicinal properties as anti-inflammatory, anti- malaria, anti- viral, anti- bacteria and anti-fungal agents. Orally administered aqueous crude extracts C. citratus and O. vulgare (100mg/kg, 200mg/kg and 400mg/kg)have no toxicological/pathological effect on wistar strain albino rats and as such, indigenous plants safe for consumption.
Flexural strength of 3D printed posterior dental restorations: A Narrative review of the literature
Authors: José Enrique Orellana Vélez  , Sebastián Anthony Gavilanes Sarmiento  , Daniela Andrea Astudillo-Rubio
Published: June 2023

The objective of this narrative review was to compare and analyze published articles on the mechanical properties of 3D printed fixed dental restorations compared to restorations fabricated with CAD/CAM and/or conventional milled composite and/or acrylic resins and to answer the following research question: Do 3D printed posterior restorations have increased flexural strength compared to restorations made of composite resin and/or acrylic resin? Articles were searched using the following electronic databases: PubMed, GOOGLE SCHOOLAR. This literature review was structured based on the guidelines given by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The PICO/PECO (Participant, Intervention/Exposure, Comparison, Outcome) focused question was: "Do restorations printed on 3D printers (I) for the posterior sector (P) have higher flexural strength (O) compared to restorations made of composite resin and/or acrylic resin (C)?". Of the two hundred and thirty-five titles, which were recognized after a primary search, fourteen articles were included in the analysis. The evidence available after performing this narrative review indicates that 3D-printed posterior fixed restorations have comparable mechanical behavior to CAD/CAM-engineered posterior fixed restorations in terms of flexural strength.
Influencing factors of smoking behavior among adolescents: A literature review
Authors: A’al Puspita  , Sinta Nuriyah Khilwatul Ilmiyah
Published: June 2023

Introduction: Smoking is a behavior that causes many problems, especially health problems. However, the number of smokers in Indonesia keeps increasing, including adolescents smokers. Although regulations have been made to reduce smoking behavior, the Indonesian people still continue to smoke. Method: This research method used literature reviews from PubMed and Google Scholar published between 2013 and 2021. Results and Discussion: The results of this study indicate that the influencing factors of smoking behavior among adolescents are the influence of friends (four articles), the influence of family (three articles), curiosity (two articles), stress level (one article), and lack of strict regulations regarding smoking behavior (one article). Conclusion: Factors that influence adolescents to smoke are the influence of friends, family influence, curiosity and trial and error, stress levels, and lack of application of regulations regarding smoking behavior.
Innovative strategies for the development of business model canvas in coconut charcoal export companies: A case study of Yogyakarta
Authors: Safiya Iskandarovna Muminova  , Bulan Prabawani  , Andi Wijayanto
Published: June 2023

This study aimed to develop a Business Model Canvas for a coconut charcoal export company based in Yogyakarta, Indonesia. The research utilized a qualitative method, including interviews with 4 stakeholders informants from coconut charcoal export company in Yogyakarta, to gather relevant data on the coconut charcoal export industry and the local market in Yogyakarta. The study also examined existing business models of successful companies in the same industry to identify best practices and key success factors. Based on the data gathered, the study developed a Business Model Canvas for the coconut charcoal export company. The model includes key components such as customer segments, value proposition, revenue streams, channels, key partners, resources, and cost structure. The Business Model Canvas developed in this study provides a practical guide for the coconut charcoal export company in Yogyakarta to identify their target customers, create unique value propositions, develop revenue streams, and identify the necessary resources and partners to achieve business success. The findings reveal that the Business Model Canvas has a significant influence on the export performance of coconut charcoal, with businesses that implemented this model achieving higher export volumes and revenue compared to those who did not. Overall, the results of this study suggest that the Business Model Canvas is a useful tool for developing a successful business strategy for the coconut charcoal export industry in Yogyakarta, Indonesia. The findings provide valuable insights for entrepreneurs and business leaders seeking to establish a business in this industry and contribute to the development of the local economy.
Mitigating the impact of global recession on construction projects: Exploring potential solutions
Authors: Taiwo Anthony Arowolo  , Oluwaseun Ebenezer Olowolayemo  , Olaosebikan Clement Babalola  , Olumuyiwa Michael Alabi  , Martins Olugbenga Popoola
Published: June 2023

The effect of global recession has caused many havoc to construction project in Nigeria, if not prevented, it can cause high cost of building materials, abandon project and insolvency. Therefore, this study examined the possible solution to the effects global recession on construction projects in Ondo state, Nigeria. This was with a view to reduce the effects of global recession on construction projects in the study area. The study is important to the construction stakeholders, policy makers and future studies. Seventy-one (71) valid questionnaires were administered among the construction stakeholders working on a construction projects in the study area, these include the Quantity surveyor, Architect, Engineer and Builder with a retrieval of Sixty-two (62). Frequency and percentage were used to analyze the demographic information of the respondents while data on possible solution to the effect of global recession on construction project was analyzed using mean score and ranking. The study concluded that Government should invest in large scale public infrastructural projects, transparency and check unethical behavior among workers, well prepared and planned budget are major possible solution to the effects of global recession in construction projects. This study recommended that Government involvement in providing the social amenities for the smooth running of the project, transparency among the stakeholders should be adopted and the scope of the project should be well understood in order to prepare a well-planned budget to curb global recession in construction industry.
Job opportunities of employees in the context of digital transformation
Authors: Yen Thi Doan  , Hong Thi Nguyen
Published: June 2023

Digital transformation is an inevitable trend and a matter of survival for countries, organizations, businesses, and workers. In Vietnam, digital transformation, which is seen as a breakthrough opportunity in the fourth industrial revolution. Digital transformation helps Vietnam mobilize and allocate resources more effectively, adopt new knowledge, technology, and international experiences, etc. In the field of employment, under the impact of digital transformation, there are significant changes in the jobs of workers, creating both opportunities and challenges. Digital transformation generates a multitude of new jobs with more diverse forms of employment. Workers have more opportunities to change their jobs and engage in various tasks on internet platforms, thereby improving income, working conditions, etc. To seize employment opportunities, it is necessary to identify and implement appropriate solutions. This article focuses on studying the employment opportunities for workers in the context of digital transformation, aiming to clarify the theoretical basis and identify employment opportunities for Vietnamese workers in the digital transformation era.
A rare association between Xeroderma pigmentosum and diffuse large B-cell lymphoma: A case report
Authors: Yasmina Benhalima  , Fatima zahra Lahlimi  , Illias Tazi
Published: June 2023

Xeroderma pigmentosum (XP) is a rare genetic disorder characterized by extreme sensitivity to ultraviolet (UV) radiation, resulting in an increased risk of skin cancer and other UV-induced malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL). It belongs to a group of cancers that affect the lymphatic system. Reports of DLBCL occurring in patients with XP are found in the literature but it seems to be quite rare. This report described a 31-year-old female patient with XP who developed DLBCL. The potential increased risk of lymphoma in XP patients is highlighted in this paper however further studies are needed to better understand the underlying mechanisms of lymphomagenesis in XP patients and to develop optimal treatment strategies for DLBCL in this setting.