bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in the main dental parameters of preschoolers with caries affected by long-term probiotic intake
Authors: Kiselnikova L. P. , Toma E. I.
Published: June 2022

Relevance. For several decades, they have added bacteria called probiotics to some foods for their positive effects on human health. In dental practice, probiotics may help fight caries and inflammatory periodontal diseases. Dentists  are interested in probiotics because of the latter’s ability to adhere to and colonize various oral tissues.

Purpose. To evaluate the clinical effectiveness of S. salivarius M18 probiotic in preschool children.

Material and methods. The study formed 2 groups (45 children in each) of children aged 3 to 6 years with multiple dental caries who underwent dental treatment and 4-fold fluoride varnish application. The main group took 2 courses of S. salivarius M18 probiotic lozenges (the 1st course from February 16 to May 16, 2021, and the 2nd course from October 26, 2021, to January 26, 2022). The children of the comparison group did not use the probiotic. We evaluated the Hygiene Index by Fedorov-Volodkina, dmf(t) rate, ICDAS-II index, and PMA index in children of both groups at the baseline and after 3, 6 and 12 months. Additionally, both groups kept food diaries. The statistical data processing was performed variance analysis of using the Friedman test (significant differences were at p ≤ 0.05).

Results. The year of observation in preschool children showed that two 3-month courses of an S. salivarius M18 probiotic intake led to a signifcant improvement in the hygiene index by 2.2 times, 2.3-fold stabilization of initial caries according to the ICDAS II index, caries decrease by 81%, gingivitis prevalence reduction (PMA index decrease by 72.9%).

Conclusion. The study results confirm the effectiveness of S. salivarius M18 probiotic in preschoolers with caries as a means of dental status correction and stabilization.
L'ideale dell’otium e la modernità:
Authors: Ricci Maria Teresa
Published: June 2022

L’articolo propone una breve storia della nozione di “otium” dall’antichità ai nostri giorni. Mostra come nella Greciaantica la vita oziosa viene considerata onorevole e come invece vengono condannati il “lavoro”, inteso nel senso di assenza dilibertà, e la ricerca della ricchezza come fine a se stessa. Queste idee riappaiono nel corso della storia, ad esempio, nella trattatistica del comportamento che fiorisce nel Rinascimento, negli ideali cortigiani, cosi’ come tra le classi marginali della società.
Libertações na poesia da palestina Fadwa Tuqan
Authors: Gonçalves Maria Carolina , Sleiman Michel
Published: June 2022

Este artigo apresenta a poeta palestina Fadwa Tuqan (1917-2003), sua hesitação em se lançar na literatura enquanto mulher criada em uma sociedade conservadora, seus primeiros passos na escrita literária e, posteriormente, a transformação de sua poesia. Proibida pela família de frequentar a escola e de sair de casa, relata, em sua autobiografia, que encontrou libertação a tal cerceamento no estudo e na escrita da poesia. Quando começou a interagir com outras poéticas, sobretudo a obra da iraquiana Názik Almalaika, que propunha uma reflexão sobre novas formas que rompessem com o modelo tradicional da literatura árabe, encontrou uma forma literária encorajadora para escrever sua própria poesia. Somam-se a essas mudanças as transformações temáticas, motivadas pelos acontecimentos que mudaram os rumos da história palestina, notadamente a criação do Estado de Israel, em 1948, e a Guerra de 1967. O artigo mostra que a inovação literária foi libertadora e abriu caminho para que as mulheres se inserissem na literatura, afastando-se das formas do discurso tradicional valorizadas na história da literatura árabe até inícios do século XX.
Notas acerca do exílio natural em Álvaro de Campos
Authors: Rovai Mauro
Published: June 2022

O objetivo deste texto é tentar compreender a noção de exílio presente nos versos do livro Vida e obras do Engenheiro (1990) de Álvaro de Campos. O uso da palavra exílio pelo poeta está mais próximo da ideia de uma alma errante (como diz Teresa Rita Lopes) do que da noção comum de exílio - entendida como aquele que está afastado do lugar de pertença.  Considerando isto, estudaremos a forma como o poeta articula as imagens evocadas por este tipo particular de exílio, que aparece sob a capa de exílio natural (num poema escrito em 06/01/1930) e depois exploraremos uma série de outros termos que ecoam ao longo do livro, como por exemplo abandono, exclusão, turista, estrangeiro, estranho, esquecer e lembrar. Embora o foco da análise seja o livro acima mencionado, faremos também uso de outros poemas e notas do Álvaro de Campos e passagens da obra de Fernando Pessoa. A ideia é estabelecer possíveis ligações entre sociologia e literatura, utilizando a discussão dos escritos do poeta como principal abordagem metodológica.
Li-Ca Alloy Composite Anode with Ant-Nest-Like Lithiophilic Channels in Carbon Cloth Enabling High-Performance Li Metal Batteries
Authors: Wang Zihao , Liu Yuchi , Xing Jianxiong , Song Zhicui , Zhou Aijun , Zou Wei , Zhou Fu , Li Jingze
Published: June 2022

Constructing a three-dimensional (3D) multifunctional hosting architecture and subsequent thermal infusion of molten Li to produce advanced Li composite is an effective strategy for stable Li metal anode. However, the pure liquid Li is difficult to spread across the surface of various substrates due to its large surface tension and poor wettability, hindering the production and application of Li composite anode. Herein, heteroatomic Ca is doped into molten Li to generate Li-Ca alloy, which greatly regulates the surface tension of the molten alloy and improves the wettability against carbon cloth (CC). Moreover, a secondary network composed of CaLi
2
intermetallic compound with interconnected ant-nest-like lithiophilic channels is in situ formed and across the primary scaffold of CC matrix by infiltrating molten Li-Ca alloy into CC and then cooling treatment (LCAC), which has a larger and lithiophilic surface to enable uniform Li deposition into interior space of the hybrid scaffold without Li dendrites. Therefore, LCAC exhibits a long-term lifespan for 1100 h under a current density of 5 mA cm
-2
with fixed areal capacity of 5 mAh cm
-2
. Remarkably, full cells paired with practical-level LiFePO
4
cathode of 2.45 mAh cm
-2
deliver superior performance.
Exploring Tree Species Classification in Subtropical Regions with a Modified Hierarchy-Based Classifier Using High Spatial Resolution Multisensor Data
Authors: Jiang Xiandie , Zhao Shuai , Chen Yaoliang , Lu Dengsheng
Published: June 2022

Tree species distribution is valuable for forest resource management. However, it is a challenge to classify tree species in subtropical regions due to complex landscapes and limitations of remote sensing data. The objective of this study was to propose a modified hierarchy-based classifier (MHBC) by optimizing the classification tree structures and variable selection method. Major steps to create an MHBC include automatic determination of classification tree structures based on the

Z

-score algorithm, selection and optimization of variables for each node, and classification using the optimized model. Experiments based on the fusion of Gaofen-1/Ziyuan-3 panchromatic (GF-1/ZY-3 PAN) and Sentinel-2 multispectral (MS) data indicated that (1) the MHBC provided overall classification accuracies of 85.19% for Gaofeng Forest Farm in China’s southern subtropical region and 94.4% for Huashi Township in China’s northern subtropical region, which had higher accuracies than random forest (RF) and classification and regression tree (CART); (2) critical variables for each class can be identified using the MHBC, and optimal variables of most nodes are spectral bands and vegetation indices; (3) compared to results from RF and CART, MHBC mainly improved the accuracies of the lower levels of classification tree structures (difficult classes to separate). The novelty in using MHBC is its simple and practical operation, easy-to-understand, and visualized variables that were selected in each node of the automatically constructed hierarchical trees. The robust performance of MHBC implies the potential to apply this approach to other sites for accurate classification of forest types.
The risk of recurrence of breast cancer in the presence of deletion polymorphism of the GSTT1 and GSTM1 genes
Authors: Gulyan I. S. , Gulyan G. S. , Eliseeva E. V. , Apanasevich V. I. , Shevchenko O. V. , Isaeva M. P.
Published: June 2022

Objective: The aim of the study was to establish the relationship between the effectiveness of chemotherapy (CMT) in case of breast cancer and the risk of recurrence with polymorphism of glutathione-S-transferase (GSTT1, GSTM1) genes.Methods: The study involved 132 women having breast cancer diagnosed, aged 23 to 79 years (average age 48 ± 13 years). They received chemotherapy treatment (neoadjuvant (NACMT), adjuvant (ACMT)). The detection of deletion (null) genotypes GSTM1 and GSTT1 was carried out using multiplex PCR followed by analysis of the melting curves of the reaction products.Results: Statistically significant connection between the presence of a null genotype GSTM1-0 and a reduced risk of breast cancer recurrence in patients having stage III BC (RR = 0.721; 95% CI: 0.524-0.992, p = 0.034). At the same time, the precense of GSTT1-0 genotype didn't have statistically significant effect on the risk of recurrence (RR = 0.543; 95% CI: 0.274– 1.077, p = 0.015). However, the tendency of the prevalence of GSTT1 0/0 among patients without recurrnece of breast cancer persisted.Conclusions: The lack of activity of the GSTT1 or GSTM1 enzymes in carriers of null genotypes can lead to a decrease in detoxification capacity and, accordingly, to a longer circulation of active metabolites of medicine and reactive oxygen species. It prolongs the time of exposure of chemotherapy drugs on tumor cells. The functionally active enzymes may increase the risk of breast cancer recurrence due to rapid elimination of drugs.
Experimental modeling of myocardial infarction in old rats
Authors: Nevzorova V. A. , Chertok V. M. , Brodskaya T. A. , Roshchenko R. V. , Plekhova N. G.
Published: June 2022

The results of modeling acute myocardial infarction on 20 male Wistar rats aged 24 months are presented. Ischemic effect is carried out by local injection of 1.5% sclerosant ethoxysclerol (0.25 ml) into the thickness of the myocardium under general anesthesia using non-traumatic needle with silicone coating, which allows to simulate acute myocardial infarction with minimal invasive effect on the animal's body, minimal trauma, little duration of intervention, low mortality, frequency of complications and absence of systemic action of drugs.
Задача розподілу ресурсів
Authors: Савченко Аліна Станіславівна , Воронін Альберт Миколайович
Published: June 2022

У різних предметних галузях актуальною є задача такого розподілу ресурсів керованої системи між окремими елементами (обʼєктами), у якому забезпечується найефективніше функціонування системи в заданих обставинах. Розглянуто проблему розподілу заданого глобального ресурсу при обмеженнях знизу, що накладаються на парціальні ресурси. Показано, що проблема полягає в побудові адекватної цільової функції для оптимізації процесу розподілу ресурсів в умовах їхньої обмеженості. Цільова функція є скалярною згорткою вектора парціальних ресурсів. Вимоги до цільової функції: вона має штрафувати парціальні ресурси за небезпечне наближення до своїх обмежень та бути диференційованою за своїми аргументами. У даній задачі парціальні ресурси мають двояку природу. З одного боку, їх можна розглядати як незалежні змінні, аргументи оптимізації цільової функції. З іншого боку, для кожного з обʼєктів логічним є прагнення максимізувати свій парціальний ресурс, піти якнайдалі від небезпечного обмеження для підвищення ефективності свого функціонування. З цієї точки зору, ресурси можуть розглядатися як часткові критерії якості функціонування відповідних обʼєктів. Ці критерії підлягають максимізації, вони обмежені знизу, невідʼємні та суперечливі (збільшення одного ресурсу можливе лише за рахунок зменшення інших). Для рішення розглянутої проблеми використовується підхід багатокритеріальної оптимізації із застосуванням нелінійної схеми компромісів. Запропонований підхід рекомендується для компромісно-оптимального розподілу ресурсів у практичних задачах широкого спектру. Приведено модельний приклад.
The nonlocal problem for fractal diffusion equation
Authors: Drin Yaroslav , Drin Iryna , Drin Svetlana
Published: June 2022

Over the past few decades, the theory of pseudodifferential operators (PDO) and equations with such operators (PDE) has been intensively developed. The authors of a new direction in the theory of PDE, which they called parabolic PDE with non-smooth homogeneous symbols (PPDE), are Yaroslav Drin and Samuil Eidelman. In the early 1970s, they constructed an example of the Cauchy problem for a modified heat equation containing, instead of the Laplace operator, PDO, which is its square root. Such a PDO has a homogeneous symbol |σ|, which is not smooth at the origin. The fundamental solution of the Cauchy problem (FSCP) for such an equation is an exact power function. For the heat equation, FSCP is an exact exponential function. The Laplace operator can be interpreted as a PDO with a smooth homogeneous symbol |σ|^2, σ ∈ Rn. A generalization of the heat equation is PPDE containing PDO with homogeneous non-smooth symbols. They have an important application in the theory of random processes, in particular, in the construction of discontinuous Markov processes with generators of integro-differential operators, which are related to PDO; in the modern theory of fractals, which has recently been rapidly developing. If the PDO symbol does not depend on spatial coordinates, then the Cauchy problem for PPDE is correctly solvable in the space of distribution-type generalized functions. In this case, the solution is written as a convolution of the FSCP with an initial generalized function. These results belong to a number of domestic and foreign mathematicians, in particular S. Eidelman and Y. Drin (who were the first to define PPDO with non-smooth symbols and began the study of the Cauchy problem for the corresponding PPDE), M. Fedoruk, A. Kochubey, V. Gorodetsky, V . Litovchenko and others. For certain new classes of PPDE, the correct solvability of the Cauchy problem in the space of Hölder functions has been proved, classical FSCP have been constructed, and exact estimates of their power-law derivatives have been obtained [1–4].  Of fundamental importance is the interpretation of PDO proposed by A. Kochubey in terms of hypersingular integrals (HSI). At the same time, the HSI symbol is constructed from the known PDO symbol and vice versa [6]. The theory of HSI, which significantly extend the class of PDO, was developed by S. Samko [7]. We extends this concept to matrix HSI [5]. Generalizations of the Cauchy problem are non-local multipoint problems with respect to the time variable and the problem with argument deviation. Here we prove the solvability of a nonlocal problem using the method of steps. We consider an evolutionary nonlinear equation with a regularized fractal fractional derivative α ∈ (0, 1] with respect to the time variable and a general elliptic operator with variable coefficients with respect to the second-order spatial variable. Such equations describe fractal properties in real processes characterized by turbulence, in hydrology, ecology, geophysics, environment pollution, economics and finance.
Benjamin’de Marksizm ve Sürrealizm İlişkisi
Authors: BİR Çağan
Published: June 2022

Bu çalışma bir felsefe, teori ve dünya görüşü olan Marksizm ile avangart bir sanat akımı olan Sürrealizmin Walter Benjamin düşüncesinde nasıl iç içe geçtiğini göstermektedir. Sürrealizmin amaçlarından biri yeni olanakların, anlamların, boyutların açığa çıkarılmasıdır. Sürrealizmin temel olarak devrimci yönü buradadır. Çalışmanın amaçladığı en önemli bağlantı sürrealizmin bilinçdışında bulduğu özgürleştirici öğeyle Benjamin’in tarihte bulduğu devrimci öğedir. Bu çalışma Benjamin’in genel olarak politika ve sanat anlayışına odaklanmamaktadır. Benjamin’e göre Sürrealizmin getirmek istediği aura ve büyü devrimciliğin ihtiyaç duyduğu sarhoşluktur. Çalışma fantazmagori, kitle kültürü, gündelik nesneler ve deneyimler gibi Sürrealizm ve devrimcilik arasında bağlantı kurulabilecek öğelere değinmektedir. Ancak asıl paralellik mitik, ilerlemeci tarih anlayışı karşısında Marksizmin iradeci devrim yorumuyla geçmişte bulunacak kurtarıcı imgelerin; Sürrealizmin bilinç karşısında bilinçdışının özgürleştirici yönünü göstermesi arasındadır. Mesihvari bir müdahalenin şimdiki zamanı, sürrealizmin zaman-mekan anlayışıyla da uyumludur. Marksizm’e göre kapitalizmde insan, ideolojinin ve meta fetişizminin etkisinde parçalanmış bir bilince ve yabancılaşmış bir varoluşa sahiptir. Benjamin’e göre sürrealizm hem yeni olanakları, anlamları görmeyi sağlayarak parçalanmış bilincin ve yabancılaşmış insanın aşılmasında hem de kapitalizm, devlet gibi kurum ve iktidar yapılarının aşılmasında Marksizm’e yardım edebilir.
The Problem of ‘Self’ in Iris Murdoch
Authors: YILDIZ Firat , TORUSDAĞ Gülşen
Published: June 2022

Iris Murdoch started her academic career as a philosopher and continued as a literary scholar. The concepts she works on in the field of philosophy are mainly the subjects under the title of moral philosophy. She turned to the field of literature after she was convinced that it would be through literature to convey the philosophical subjects she was working on to a wider audience. Although she claims that her philosophy is not related to the literary works she produces, it is possible to see the reflections of her philosophy in her novels. One of the important concepts that Murdoch emphasizes in her moral philosophy is the 'self'. The ‘self’ problem has been one of the topics that many different disciplines dealt with. This issue emerges as a common concept that Murdoch emphasizes both in her philosophy and in her literary works. She has based her philosophy on Plato's allegory of the cave while working on this concept. According to this allegory, while a few of the people approach the truth, only a few of them can see the truth as it is. According to Murdoch, one of the barriers between man and reality is the 'self'. The self does not see events, people and objects in their own reality. The self paints beings and events outside itself with the paint of its own consciousness. The motive behind doing this is that he cannot bear the pain of seeing the truth directly. In order to cover up the disturbing nature of reality, the self makes it more bearable by looking at events and beings from the window of its own consciousness. In this respect, the self is protected from the truth. Murdoch considers it a virtuous act for the individual to get rid of his ego and see the facts as they are. She argues that very few people are able to achieve this. There are various situations – like a true work of art – that will enable the individual to get rid of the self. Some examples of self and unselfing are discussed in this study.
PENGETAHUAN IBU HAMIL TENTANG FUNGSI PEMANFAATAN BUKU KIA TAHUN 2020
Authors: Sari Mitra , Arlis Izzawati , Putri Anjeli Ratih Syamlingga
Published: June 2022

ABSTRAK

Kurangnya pengetahuan ibu tentang penggunaan buku Kesehatan Ibu dan Anak (KIA) yakni masih dianggap sebagai buku pencatatan kesehatan bagi petugas kesehatan, menjadi kendala dalam pembentukan perilaku kesehatan ibu hamil. Tujuan dari penelitian ini adalah untuk mengetahui pengetahuan ibu hamil tentang pemanfaatan buku KIA di Desa  Kampung Besar Kota wilayah kerja UPTD Puskesmas Kampung Besar Kota tahun 2020. Penelitian ini bersifat deskriptif dengan teknik pengambilan sample yaitu accidental sampling. Hasil Penelitian menunjukan bahwa mayoritas responden memiliki tingkat pengetahuan baik tentang fungsi manfaat buku KIA yaitu  sabanyak 20 orang (66,67 %). Maka dapat disimpulkan bahwa secara keseluruhan pengetahuan ibu hamil tentang fungsi pemanfaatan buku KIA di Kampung Besar Kota tahun 2020 didapatkan hasil mayoritas berpengetahuan baik.
HUBUNGAN PENDIDIKAN DENGAN UPAYA PENCEGAHAN COVID-19 DI DESA LAKSAMANA KECAMATAN SABAK AUH KABUPATEN SIAK
Authors: Wulandini Putri , Sukarni Sukarni
Published: June 2022

Corona virus or better known as Covid-19 has a new variant. Where at the beginning of the emergence there was an increase in the death rate, but now it has decreased. But there are new variants that are delta, and omicron. So that efforts to prevent the spread must still be carried out properly without being ignored. The purpose of this study was to determine the relationship between education and efforts to prevent Covid-19 in Laksamana Village, Sabak Auh District, Siak Regency in 2021. The design of this study was quantitative correlation. The population is the entire community of Laksamana Village. by using purposive sampling technique, a sample of 134 people. Questionnaire instrument. The results showed that there was a significant relationship between education and prevention efforts (p=0.000). Education is expected to increase public awareness and a better understanding of Covid-19 prevention.
KECEMASAN IBU HAMIL DALAM MASA PANDEMI COVID-19 DI WILAYAH KERJA PUSKESMAS MINAS
Authors: Alwi Nike Puspita , Fitri Ainil , Astari Winnie
Published: June 2022

Covid-19 still be a pandemic in Indonesia since two years ago. The vulnerable age group are the elderly, the people who has comorbid condition and pregnant woman. Pregnancy will be risk to worsen symptoms and also to maternal and the fetus health. This study aims to describe about the anxiety of Maternal Pregnancy during pandemic Covid-19. The design of this study is descriptive. The population of this study is 98 of pregnant woman who settle in Minas Public Health Center Work Area. The sample was chosen by total sampling technique. Data were collected by using HARS (Hamilton Anxiety Rating Scale) questionnaire. The result finding showed that there are 18,4% respondents didn’t anxiety, 54,1% mild anxiety, 27,6% moderate severity of anxiety, and no respondents has severe or panic (an overwhelm anxiety severity) during Covid-19 Pandemic. We can conclude that Covid-19 in fact brought mild severity to pregnant woman. Minas Public Health Center should give health education about guidelines for pregnancy in pandemic and also how to control the worries pregnancy and health during Covid-19.
Predictors of long-term ventricular tachyarrhythmia recurrence after combined endo-epicardial ablation in patients with structural heart disease
Authors: Simonova K. A. , Orshanskaya V. S. , Lebedeva V. K. , Garkina S. V. , Lyubimtseva T. A. , Vander M. A. , Miller Yu. V. , Tatarsky R. B. , Kamenev A. V. , Naymushin M. A. , Lebedev D. S. , Mikhaylov E. N.
Published: June 2022

Purpose. To identify predictors of ventricular tachycardia (VT) recurrence after endo-epicardial ablation in patients with structural heart disease.

Methods. A prospective observational study included 39 patients with structural heart disease and indications for catheter ablation of ventricular tachyarrhythmia. Endo- and epicardial electroanatomical mapping of the ventricular myocardium and ablation of abnormal electrical activity areas were performed. Clinical, ECG characteristics, and voltage maps of bipolar potentials (limits of scar detection <0.5 mV, normal activity >1.5 mV) and unipolar signals (limits <5.0 and >9.0 mV, respectively) on endo- and epicardial surfaces were evaluated. Intraprocedurally, the procedure was considered effective when no VT was inducible; partially effective - when only clinical VT(s) was/were non-inducible. Scheduled patient visits or remote monitoring were performed at 6, 12 and 24 months, and then annually.

Results. The mean age of the patients was 49.5±15.7 years (34 men and 5 women). VT recurrences at 6 months were more often detected in non-ischemic cardiomyopathy patients, in subjects with non-paroxysmal atrial fibrillation (42.9% vs. 7.4%), with a lower VT-QRS amplitude in lead III (0.6 [0.4;1.07] versus 1.28 [0.99; 1.53] mV), and when epicardial “scar” area prevailed over endocardial, P<0.05 for all listed parameters. At 12-months, VT recurrence was more common in patients with partially effective ablation (33.3% vs. 5.0% in patients with effective ablation, P=0.02). The presence of electrical storm at the time of ablation was independently associated with recurrences (HR 4.32; 95% CI: 1.06-17.48; P=0.04).

Conclusion. In a heterogeneous group of patients, clinical and electrophysiological factors associated with VT recurrence have been identified at various follow-up periods after endo-epicardial ablation. Electrical storm ablation is an independent predictor of VT recurrence in the long-term, up to 5 years of follow-up.
PENGARUH PERUBAHAN PENGGUNAAN LAHAN TERHADAP DEBIT PUNCAK DI DAS PEUSANGAN BIREUEN
Authors: Pratiwi Hilda , Yusdiana Yusdiana
Published: June 2022

The purpose of this study were to analyze and determine the magnitude of the effects of land use changes for run off coefficient and peak flows in Krueng Peusangan This study held in Krueng Peusangan, Bireuen. Land use changes in Krueng Peusangan on period 2015 - 2019 is of secondary forest decreased covers 1950 ha (2,41%), reduced mixed land farming 1241 (1,54%), ricefield 812 ha (1,00%) and the dry land agriculture 97 ha (0,12%), while the addition of comprehensive settlement of 2150 ha (2,66%), and shrubs thicket 1950 ha (2,41%) of the total area of Krueng Peusangan. Runoff coefficient value (C) increased from 0.19 in 2015 to 0.20 in 2019.

Keyword: DAS, land use, runoff coefficient
ANALISIS STRATEGI PEMASARAN UNTUK MENINGKATKAN PENJUALAN PRODUK BROWNIES COKLAT PADA UD DHENOK GROUP
Authors: Aditya Prayudhi Luhur , Zamrodah Yuhanin
Published: June 2022

The availability of cocoa beans is very large in the Blitar area so that it opens up considerable business opportunities for the people in Blitar. In addition, cocoa plants as a producer of cocoa beans can thrive in the Blitar area, making it easy to obtain raw materials. Processing of basic ingredients of chocolate in the Blitar area is still minimal, so it is very necessary to diversify products from chocolate. One of the products here is chocolate brownies where an effective marketing strategy is needed to increase sales of Chocolate Brownies. The purpose of this study was to determine the marketing strategy of Chocolate Brownies products with SWOT analysis.

The marketing system carried out at UD Dheenok Group uses a direct marketing system, namely sales at industrial sites and indirectly by distributing products to Kampung Chocolate as a working partner in marketing. customers, while the weakness lies in unwritten financial administration, and does not have investors so that it has an impact on business development and the absence of visual promotion media such as advertisements. market due to the lack of similar products in Blitar City. The biggest threat faced in marketing chocolate brownies is the price of raw materials for eggs that fluctuates and the product expiration period is short, which is around 10 days. The marketing strategy used by UD Dheenok group in developing chocolate brownie processed food products is a business strategy, namely product excellence
Reología de mezclas de asfaltos nacionales con polímeros del isobutileno
Authors:   , Agnusdei Jorge
Published: June 2022

En este trabajo, se ha procedido a realizar un estudio de las condiciones de flujo de mezclas de asfaltos obtenidos de petróleos crudos nacionales y polímeros del isobutileno, con especial referencia al cambio de la susceptibilidad térmica del asfalto por el agregado de esos elastómeros. Dicho cambio de propiedades reológicas es de importancia en muchas de las aplicaciones industriales del asfalto y está estrechamente vinculada al comportamiento en servicio cuando el material actúa como adhesivo, relleno de juntas o impermeabilizante.
Tuberculosis renal
Authors:   , Nápoli Antonio Oscar
Published: June 2022

La T.B.C. renal corresponda a uno de los capítulos de la urología de mayor importancia y ello se debe 1º) a la difusión de la enfermedad. 2º) a su gravedad porque si no se le diagnostica a tiempo y es convenientemente tratada, lleva después de un período variable a la muerte del enfermo casi sin excepción. Veremos más adelante su gran frecuencia y por lo tanto la necesidad de tenerla presente cuando se revisa un enfermo con sintomatología renal y sobre todo si esto oscila entre los 20 y 40 años. Si bien es cierto que tomada a tiempo y convenientemente tratada evoluciona favorablemente y más hoy que contamos con el poderoso auxilio de la estreptomicina, no por eso dejaremos de recalcar su gravedad, máxime teniendo en cuenta que se trata de enfermos con otra lesión T.B.C. visceral latente o en evolución y como tal debemos orientas su tratamiento.
Disaster Impacts and Risk Reduction Measures in Library Structure and Functions
Authors: KUZUCUOGLU Alpaslan Hamdi
Published: June 2022

There are many disasters and emergencies in the world. The main reasons are climate change and urbanization. Migration from rural to urban areas is increasing day by day, and industrial activities cause more people to concentrate in cities. As a natural consequence of this, people face the threat of natural disasters. Emergencies and risks caused by human effects also threaten libraries, which are important information centers. These centers, which have a large number of people at the same time, are very vulnerable, especially under the effects of natural-oriented disasters. The main reasons for this are the presence of a large population at the same time, problems arising from buildings and equipment, inadequate precautions against earthquakes, fires and floods, the fragile nature of the library collection against disasters, and inadequate preparedness. The effects of natural disasters that may occur in library structures as well as the preventive risk reduction measures for these disasters, disaster awareness through disaster slogans are emphasized in this study.
Association between Serum Uric Acid Level and Chronic Kidney Disease
Authors: Wariki Maria C. , Waleleng Bradley J. , Pandelaki Karel
Published: June 2022

Abstract: As already known, chronic kidney disease (CKD) could result in a change of serum uric acid (SUA) level which leads to hyperuricemia. However, many studies suggest that SUA level has an important role in CKD progression and independently associated with a new onset of CKD. This study aimed to find out the independent association between SUA level and CKD. This was a literature review study using databases of Google Scholar and Pubmed. The results obtained 10 articles that met the inclusion and exclusion criteria. All studies proved that there was an association between SUA level and CKD. An elevated SUA level, known as hyperuricemia, was a risk factor in renal impairment and CKD progression. In conclusion, there is an independent association between SUA level and CKD.Keywords: serum uric acid; chronic kidney disease Abstrak: Telah diketahui bahwa penyakit ginjal kronis (PGK) dapat memengaruhi kadar asam urat dan mengakibatkan hiperurisemia. Banyak penelitian yang telah dilakukan membuktikan bahwa kadar asam urat secara independen memengaruhi terjadinya PGK. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat serum dengan PGK. Jenis penelitian ialah suatu literature review dengan menggunakan database Google Scholar dan Pubmed. Hasil penelitian mendapatkan 10 artikel yang sesuai dengan kriteria inklusi dan eksklusi. Kesepuluh artikel menun-jukkan adanya hubungan independen antara kadar asam urat serum dengan PGK. Peningkatan kadar asam urat serum yang dikenal dengan hiperurisemia dianggap sebagai salah satu faktor dalam progresifitas gangguan ginjal dan PGK. Simpulan penelitian ini ialah terdapat hubungan antara kadar asam urat serum dengan PGK.Kata kunci: asam urat serum; penyakit ginjal kronis
Inhibidores del SGTL-2 en pacientes con insuficiencia cardiaca y fracción de eyección reducida con o sin diabetes: revisión sistémica
Authors: Mejia-Zambrano Henry
Published: June 2022

Objetivo: Determinar los beneficios de los inhibidores del SGLT-2 en pacientes con insuficiencia cardiaca y fracción de eyección reducida con o sin diabetes. Métodos: En esta revisión sistemática se incluyeron estudios experimentales, estudios de los inhibidores de SGLT-2 en pacientes con insuficiencia cardiaca con fracción de eyección reducida con o sin diabetes. Se realizo una síntesis narrativa formal de los datos recogidos en español e inglés. Las síntesis se centraron en el análisis cualitativo. La calidad de evidencia para cada desenlace se determinó según la metodología Grading of Recommendations Assessmet, Developmet and Evaluation (GRADE). Resultados: En lo general, los eventos primarios en los pacientes con insuficiencia cardiaca con fracción de eyección reducida del grupo de los inhibidores de SGLT-2 fueron menores respecto al grupo placebo (IR:0.65; IC del 95%: 0.64-0.80; p=0.40). Los resultados por muerte cardiovascular en el grupo de los inhibidores del SGLT-2 fueron menores respecto al grupo placebo (IR: 0.60; IC del 95%: 0.40-0.70; p=0.50). Los resultados adversos en los pacientes del grupo de los inhibidores del SGLT-2 fueron menores que el grupo placebo (37% vs 42%, respectivamente) de los diversos estudios. Conclusión: Los inhibidores del SGLT-2 mejoran las alteraciones cardiovasculares, incluida la insuficiencia cardiaca con fracción de eyección reducida y preservada, además reducen la moralidad cardiovascular en pacientes con o sin diabetes.
Utilidad del Cobas® Taqman® Ct Test, v2.0 para la detección de cepas de Chlamydia Trachomatis circulantes en México
Authors: López-Hurtado Marcela , Flores-Salazar Verónica R. , Gutierréz-Trujillo Rodrigo , Escobedo-Guerra Marcos R. , Guerra-Infante Fernando M.
Published: June 2022

Objetivo: Evaluar la utilidad de la prueba de qPCR de COBAS® TaqMan® Chlamydia trachomatis (CT) para la detección de cepas circulantes en México. Materiales y Métodos: Estudio descriptivo y transversal. Se analizaron 413 muestras endocervicales por el sistema COBAS® de pacientes con infertilidad, con el diagnóstico de C. trachomatis. que acudieron a la Clínica ETS del Instituto Nacional de Perinatología (INPer) en la Ciudad de México. Las muestras positivas también analizaron por el sistema Abbot Real-time CT / NG, y por PCR de punto final para la detección de plásmido. Las variables de estudio fueron: Infertilidad, diagnóstico de Chlamydia trachomatis, infección por Chlamydia y otras variables. Para determinar la asociación entre la infección por CT y los datos clínicos se utilizó la prueba no paramétrica exacta de Fisher. Un valor p<0.05 fue considerado como significativo. Resultados: De las 413 muestras, 276 pacientes femeninas con infertilidad primaria y 137 de infertilidad secundaria, con edades de 20 a 42 años. La principal causa de infertilidad primaria fue factor endocrino-ovárico y de infertilidad secundaria fue el factor tuboperitoneal. De 22 muestras fueron positivas, una asociación significativa entre la infertilidad por factor tubárico y la infección por C. trachomatis (RR = 2,47 IC95% 1,1-5,5, p <0,05) fue demostrada por la prueba COBAS® TaqMan® CT. De éstas solo 5 fueron identificadas por el sistema Abbott (p <0.011). Conclusión: El sistema de COBAS® TaqMan® CT de Roche Molecular Diagnostic mostró mayor utilidad para identificar las cepas de CT que están circulando en México.
JamRF: Performance Analysis, Evaluation, and Implementation of RF Jamming over Wi-Fi
Authors: Ali Abubakar S. , Baddeley Michael , Bariah Lina , Andreoni Martin , Lunardi Willian T. , Giacalone Jean-Pierre , Muhaidat Sami
Published: June 2022

Jamming attacks significantly degrade the performance of wireless communication systems and can lead to significant overhead in terms of re-transmissions and increased power consumption. Although different jamming techniques are discussed in the literature, numerous open-source implementations have used expensive equipment in the range of thousands of dollars with the exception of a few. These implementations have also tended to be partial band, and do not cover the whole available bandwidth of the system under attack. In this work, we demonstrate that flexible, reliable, and low priced software-defined radio (SDR) jamming is feasible by designing and implementing different types of jammers against IEEE 802.11n networks. First, to demonstrate the optimal jamming waveform, we present an analytical bit error rate expression of the system under attack by employing two common jamming waveforms: Gaussian noise and digitally modulated. Then, we validate this analysis through simulations using the MATLAB WLAN toolbox. Afterwards, we implement JamRF, a toolkit that employs a low-cost SDR to implement numerous types of jammers to validate the analysis. Obtained results showed that, to jam the whole 2.4GHz spectrum, a stateful-reactive jammer employing random channel hopping jamming strategy, achieves a packet loss ratio above 90%. 
SAP: A Low-latency Protocol for Mitigating Evil Twin Attacks and High Computation Overhead in WI-FI Networks
Authors: Jain Vineeta , Wetzker Ulf , Laxmi Vijay , Gaur Manoj Singh , Mosbah Mohamed , Mery Dominique
Published: June 2022

In this manuscript, we analyze the security offered by existing 802.11 protocols against one of the most basic yet detrimental Evil Twin (ET) attacks. To comprehensively protect Wi-Fi networks against such attacks, vulnerabilities in the IEEE 802.11 specifications were addressed by new and improved security mechanisms. Unfortunately, each of the existing 80 2.11 protocols resulted in a significant increase in communication and computation overhead, making them unsuitable for low latency applications such as health care, intelligent transportation systems, robotics, Industrial Internet of things (IIoT), etc. A protocol is needed which provides optimum security against contemporary network attacks while keeping the latency and overhead maintained. In this work, we propose a secure and low latency protocol known as SAP, which incurs low computation overhead, exchanges less number of messages, does not require any pre shared knowledge, and yet provides end to end security to messages exchanged, making it ideal for embedded and IIoT applications. The protocol is validated using formal verification techniques and experimental simulation.
Method-of-Moments Modeling of Conducting Objects within the Fast Irregular Antenna Field Transformation Algorithm
Authors: Kornprobst Jonas , Paulus Alexander , Eibert Thomas F. , Mauermayer Raimund A. M.
Published: June 2022

Reducing near-field measurement times is an important challenge for future antenna measurement systems. We propose to incorporate knowledge about material parameters of the antenna measurement environment within the simulation model. To do so, a method-of-moments code with surface discretization is implemented as a side constraint to the near-field far-field transformation problem performed with the fast irregular antenna field transformation algorithm. Transformation and source reconstruction results of synthetic measurement data demonstrate the effectiveness of the proposed method.
Approximate Noise-Whitening in MIMO Detection via Banded-Inverse Extension
Authors: Hu Sha , Wang Hao
Published: June 2022

 

In this paper, we propose a novel approximate noise-whitening for multi-input multi-output (MIMO) detection with banded-inverse extension (BIE). If a noise covariance matrix origins from a Gauss-Markov process (GMP), its inverse is banded and the proposal is exact and yields no accuracy-losses. For general matrices to be inverted, the approximation-errors from inversion introduce a mismatched MIMO detection-model, which can cause performance-degradation. Hence, we develop an information-theoretic tool with generalized mutual information (GMI) to evaluate the impacts from approximation-errors on the final achievable rate. We show that the approximate noise-whitening method based on BIE not only minimizes the noise-distortion measured from the Kullback-Leibler (KL) divergence, but also asymptotically maximizes GMI of the MIMO system as signal-to-noise ratio (SNR) increases. Besides, the proposal also provides a unified framework for approximate matrix-inverse with an adjustable band-size that can tune the trade-off between complexity and accuracy.
Monitoraggio della rinnovazione naturale di specie arboree nella foresta di Vallombrosa
Authors: Passarino Livia , Galipò Giovanni , Travaglini Davide
Published: June 2022

In questo lavoro è stata esaminata la rinnovazione naturale di specie arboree forestali nella foresta di Vallombrosa in soprassuoli danneggiati dalla tempesta di vento del 2015. Il lavoro è stato condotto in quattro aree di studio che in precedenza ospitavano fustaie di abete bianco e di abete rosso. I rilievi sono stati eseguiti all’interno di transect disposti sui margini e all’interno delle aree disturbate dal vento. Dopo cinque anni dalla tempesta, nelle aree di studio è stata rilevata la presenza di rinnovazione di 11 diverse specie arboree forestali. L’abete bianco è risultata la specie più frequente, associata ad altre conifere come douglasia e pino laricio e a latifoglie decidue come faggio, castagno e cerro. La densità della rinnovazione nelle aree esaminate è compresa tra 0,68 e 1,13 piantine/m2, con un valore medio di 0,83 piantine/m2. Per l’abete bianco, l’indice di rinnovazione di Magini è risultato superiore sui margini delle aree investigate. Lo studio presenta i risultati di un’attività di monitoraggio che può aiutare a migliorare le conoscenze sulle dinamiche dei processi della rinnovazione forestale in aree disturbate da eventi estremi come le tempeste di vento.
Mixed Connective Tissue Disease (MCTD) or SHARP Syndrome: A Case Report with Review of the Literature
Authors: Abbasse ABBA , Moustapha NIASSE , Mohamed DIABY Ladji , Hassan ALI
Published: June 2022

Mixed Connective Tissue Disease or SHARP Syndrome was originally described by Gordon. C. Sharp as a syndrome combining clinical signs of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma, polymyositis/dermatomyositis (PM/DM), associated with an elevated level of ribonuclease-sensitive antinuclear antibodies. These antibodies were later defined as anti-U1-RNP antibodies. In routine practice, the clinical and immunological distinction between mixed and overlapping connectivitis or a particular form of differentiated connectivitis is sometimes difficult and has little therapeutic consequence. Nevertheless, this can be an ease of approach for the therapist and an ease of understanding for the patient. We report a case of Sharp's syndrome diagnosed in a 37-year-old female patient at the CHU Aristide LeDantec in Dakar, Senegal.
Duodenal Diverticulum: An Unusual Cause of Pancreatitis
Authors: Fahl A. , Laanait A. , Arbouni H. , Tabakh H. , Siwane A, , Touil N. , Kacimi O. , Chikhaoui N.
Published: June 2022

Duodenal diverticula are anatomical entities which, although quite frequent, remain most often asymptomatic and of incidental discovery following a radiological examination. Their clinical expression during diverticulitis, pancreatitis and cholangitis poses a diagnostic problem and must therefore be evoked and recognized in imaging. The objective of this work is to highlight and discuss the different clinical presentations, the radiological aspects and their complications as well as the various differential diagnoses.
Sars-Cov-2 Mutations: Platforms Used for Their Analysis and Evolution
Authors: Hernández Angel San Miguel , Rodríguez Julia San Miguel
Published: June 2022

The biology of the SARS-CoV-2 virus leads to constant changes in its genome through mutations, so the appearance of variants is an expected fact. Since evolutionary adaptation and diversification has been observed globally throughout the pandemic. Most of the mutations that arise do not provide a selective advantage to the virus, or phenotypic changes that imply alterations in the behavior of the infection. There is concern with the appearance of one or more variants that escape the effect of the neutralizing antibodies generated after a previous infection or vaccination, which could lead to cases of reinfection or loss of vaccine efficacy. These variants could be associated with a decrease in the sensitivity of certain diagnostic techniques, although most of these techniques use several different genes to avoid this effect. The genomic sequencing of SARS-CoV-2 and the platforms used to monitor the different varieties and observe how they are circulating around the world are reviewed.
Frequency of IgG Antibodies to Pertussis Toxin Antigen among Antenatal Women Attending a Tertiary Care Hospital in Hyderabad
Authors: N Dr. Srinivas , Kathyayani Dr. Y.
Published: June 2022

Introduction: Pertussis is a vaccine preventable disease. Recently the is a rise in number of cases of Pertussis in developed countries. Under Universal Immunisation Programme in India two doses of TT vaccine are administered. One dose at 5 months of gestation or as soon as detection of pregnancy and the other 4 weeks apart. American College of Obstetricians and Gynecologists recommends a dose of Tdap during pregnancy. CDC also recommends a dose of Tdap vaccine to all pregnant women between 27- 36 weeks of gestation. This study has been conducted to know the level of IgG antibodies against Pertussis toxin in antenatal women since there is a dearth of literature in this aspect. Materials & Methods: Blood samples have been collected from 91 Antenatal women attending outpatient department of Tertiary Care Hospital, Hyderabad after obtaining consent. Serum has been separated and stored at -200C. ELISA has been put up against Pertussis toxin and Serum Anti-Pertussis toxin IgG antibody levels were analysed. Results: A value of >30 IU/ml was accepted as potential protective concentration, 20 -30 IU/ml as borderline &<20 IU/ml as negative. We found that the percentage of protected, borderline and unprotected antenatal women respectively were 16.48%, 9.89% & 73.62% for anti PT. Discussion: Most pregnant women in this study demonstrated low anti PT IgG. This finding suggests that a significant number of women & newborn were susceptible to Pertussis. Conclusion: Our results explained the susceptibility for Pertussis among pregnant women and also newborn born to them & supported the requirement for a Pertussis booster vaccine during pregnancy along with Tetanus and Diphtheria which may provide passive seroprotection in newborns during first months of life decreasing severity of illness and providing seroprotection.
The Development of Biology Module Based On Stem-CP to Improve Critical Thinking and Self-Regulated Learning
Authors: Paramita Galuh , Sutarto Sutarto , Subchan Wachju , Indrawati Indrawati
Published: June 2022

This research aimed at improving critical thinking and SRL (Self Regulated Learning) ability based on STEM-CP (Science, Technology, Engineering Dan Mathematic- Contextual Problem) by using module. This research employed a research and development (R&D) method, which was used as actual proof in improving a learning media of STEM-CP based modul. There were 12 schools, including state or private schools, and 12 biology teachers as need analysis involved in this study. A needs assessment was conducted by using a questionnaire generated in Google form. The result of the needs assessment showed that teachers 70% of stated so far the learning process has not run optimally, the media that has been used so far have not maximized the learning process of 66,6%, and 83.3% of teachers stated that learning had used modules, but 16.6% stated that the learning process had not used modules. The fact is that in learning the teacher has used the module but it has not maximized the learning process. The STEM-CP module is expected to be able to improve students' critical thinking skills and SRL (Self Regulated Learning).